NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

PI_NAMEs: ARTANDI, STEVEN E (contact)

PROJECT_TERMS: acronyms;Address;Appointment;Area;Award;Basic Science;Breast;Cancer Biology;Cancer Center Support Grant;Cancer Detection;cancer diagnosis;Cancer health equity;cancer immunotherapy;cancer stem cell;Catchment Area;Clinical;Clinical Research;Clinical Trials;Collaborations;Communities;community advisory board;community engagement;Community Outreach;Dedications;design;Development;Discipline;Doctor of Philosophy;drug discovery;Early Diagnosis;Faculty;Faculty Recruitment;Fostering;Funding;Funding Agency;Genomics;Goals;Grant;Hematologic Neoplasms;imaging detection;innovation;Institution;Investments;Joints;Journals;Lead;Leadership;lifestyle intervention;Lung;Malignant neoplasm of lung;Malignant Neoplasms;medical schools;meetings;Melanoma;member;Minority Groups;Mission;Nodal;novel marker;novel therapeutics;Pancreas;Pilot Projects;Population Sciences;Population Study;Prevention;programs;Publications;Radiobiology;Recommendation;recruit;Research;Research Activity;Research Personnel;Research Support;Resource Allocation;Resources;Risk Assessment;Science;Strategic Planning;Therapeutic;translational scientist;Underrepresented Populations;Underserved Population;Woman

PROJECT_TITLE: Developmental Funds


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer

ORG_CITY: STANFORD

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PI_NAMEs: MAECKER, HOLDEN T. (contact)

PROJECT_TERMS: acronyms;Animals;anti-cancer research;Biological Sciences;biomedical informatics;Biometry;Biostatistics Shared Resource;Budgets;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cancer Detection;cancer imaging;cancer immunotherapy;cancer stem cell;Cells;Competence;cost effective;Data;design;Development;Doctor of Philosophy;Early Diagnosis;Education;Equipment;Evaluation;Faculty;Feedback;Flow Cytometry;Flow Cytometry Shared Resource;Funding;Future;Genomics;Genomics Shared Resource;Grant;Hematologic Neoplasms;Human;Image;imaging detection;Immunologic Monitoring;Immunology;informatics shared resource;innovation;Institution;instrumentation;Investments;Leadership;Maintenance;Malignant Neoplasms;medical schools;meetings;member;Microbiology;Modeling;Monitor;new technology;Occupational activity of managing finances;operation;Policies;Population Sciences;Process;professor;programs;Proteomics;Proteomics Shared Resource;Publications;Radiobiology;Recording of previous events;Reporting;Research;Resource Sharing;Resources;Review Committee;Safety;Science;screening;Services;Strategic Planning;Surveys;Technical Expertise;Techniques;Technology;Therapeutic;Tissue Procurements;Training;Training Activity;Training and Education;tumor;United States Preventative Services Task Force;Universities

PROJECT_TITLE: Shared Resources Management

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Asthma;Lung;Women's Health Research

ORG_CITY: RICHMOND

ORG_DEPT: BIOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative Mast cell activation by IgE antibodies is a central factor in allergic disease. Our data show that the ATP receptor, P2X3, amplifies mast cell responses to IgE. This previously unknown pathway is selectively active in females and could help explain female-biased asthma disparities. Importantly, P2X3 can be targeted with available drugs, including the antidepressant, fluoxetine (Prozac). This study will therefore uncover basic and translational aspects of allergic disease.

PI_NAMEs: RYAN, JOHN J (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: allergic airway inflammation;Allergic Disease;Allergic inflammation;Amplifiers;anti-depressive agents;Antibodies;Asthma;ATP Receptors;autocrine;B-Lymphocytes;Cell Physiology;Cells;Cellular biology;Clinical;Data;Disease;Disparity;Disproportionately impacts women;drug repurposing;eosinophil;Estrogens;Extrinsic asthma;Female;Fluoxetine;Human;Hypersensitivity;IgE;In Vitro;in vivo;Incidence;inhibitor;Intervention;Knockout Mice;male;MAP Kinase Gene;mast cell;Mediating;Membrane;Modeling;Molecular;Mus;Natural Immunity;novel;P2X-receptor;pain sensation;pain signal;patch clamp;Pathology;Pathway interactions;Pharmaceutical Preparations;Production;Proteins;Public Health;Pyroglyphidae;receptor;release of sequestered calcium ion into cytoplasm;response;Role;selective expression;sex;Sex Bias;sexual dimorphism;Signal Induction;Signal Transduction;Testing;Therapeutic;translational progress;Woman

PROJECT_TITLE: P2X3 is a Female-Dominant Amplifier of Mast Cell Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-B(02)]


NIH_SPENDING_CATS: Cancer

PROJECT_TERMS: anti-cancer research;Antineoplastic Agents;Appointment;Area;Attention;Award;Basic Science;Cancer health equity;Catchment Area;chimeric antigen receptor T cells;Clinical;Clinical Research;Clinical Sciences;Collaborations;Communities;community advisory board;community collaboration;community engagement;Community Outreach;Consensus;Development;Doctor of Philosophy;drug discovery;Education;Education and Outreach;Effectiveness;Epidemiology;Evaluation;Faculty Recruitment;Feedback;Funding;Goals;Grant;Growth;innovation;investigator-initiated trial;Lead;Leadership;Malignant Neoplasms;member;Mentors;Mission;Peer Review;Policies;population health;Population Sciences;Positioning Attribute;Process;Productivity;programs;Publications;recruit;Research;Research Support;Resource Sharing;Role;Strategic Planning;Structure;success;Surveys;Training;Training and Education;Translational Research;treatment trial;Underrepresented Minority;Update

PROJECT_TITLE: Leadership, Planning and Evaluation


NIH_SPENDING_CATS: Cancer;Patient Safety

PI_NAMEs: ANDERSON, ELIZABETH  (contact)

PROJECT_TERMS: 18 year old;African American;Age Years;Award;Black race;Cancer Center Support Grant;cancer clinical trial;Cancer health equity;Catchment Area;chimeric antigen receptor T cells;Clinical Data;Clinical Oncology;Clinical Protocols;Clinical Research;Clinical Trials;Collaborations;community engagement;Complex;Conduct Clinical Trials;County;COVID-19 pandemic;Data;Data Collection;data management;Databases;demographics;Development;diversity and inclusion;Doctor of Philosophy;Education;Ensure;Female;Fostering;Funding;improved;Individual;Intervention;Intervention Studies;Intervention Trial;Leadership;life span;Malignant Neoplasms;member;Minority;Minority Groups;Monitor;National Cancer Institute;Occupational activity of managing finances;Office Management;operation;Participant;participant safety;patient population;Patients;Physician Executives;Population;Procedures;Process;programs;protocol development;quality assurance;recruit;Reporting;Research;Research Institute;Research Personnel;Retirement;Role;Safety;Services;Strategic Planning;System;targeted treatment;Technology;Training and Education;Underrepresented Populations;Woman;Work

PROJECT_TITLE: Clinical Protocol and Data Management


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Biotechnology;Cancer;Emerging Infectious Diseases;Genetics;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Narrative The human gammaherpesviruses Epstein-Barr virus (EBV) and Kaposi’s sarcoma-associated herpesvirus (KSHV) are linked to the development of a wide range of B cell lymphomas. The differentiation of infected B cells into memory B cells occurs in the lymphoid structure termed the germinal center (GC). We have recently demonstrated that a gammaherpesvirus noncoding RNA manipulates the GC to establish infection. In work here, we will determine the mechanism by which the manipulation occurs and define its importance in virus biology and the host immune response.

PI_NAMEs: TIBBETTS, SCOTT A. (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Antigens;Automobile Driving;B-Cell Lymphomas;B-Lymphocytes;Binding;Biological;biological adaptation to stress;Biology;Cells;Cellular biology;Chimeric Proteins;Dangerousness;defined contribution;Development;Disease;DNA Damage;Event;Ewings sarcoma;Foundations;gammaherpesvirus;Genetic;Genetic Recombination;Goals;Herpesviridae;HIV;Human;Human Herpesvirus 4;Human Herpesvirus 8;Immune response;Immunocompromised Host;in vivo;infected B cell;Infection;latent infection;Link;lymphoid structures;Lymphoma;Lymphomagenesis;Malignant - descriptor;Malignant Neoplasms;Mediating;Memory B-Lymphocyte;Messenger RNA;MicroRNAs;Molecular;mRNA Stability;Mus;novel;Pathogenicity;prevent;Process;Proliferating;Proteins;rational design;Reaction;Regulation;Repression;Rest;RNA Splicing;RNA-Binding Protein EWS;RNA-Binding Proteins;Role;Species Specificity;Structure of germinal center of lymph node;System;Testing;Transcription Coactivator;Transcription Repressor;tumorigenesis;Untranslated RNA;Validation;Viral;Viral Physiology;Viral reservoir;Virus;Work

PROJECT_TITLE: Gammaherpesvirus miRNA suppression of EWSR1 in GC B cell infection and lymphomagenesis

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Public Health Relevance The immune system is one of our best guards against developing cancer and when this system fails, cancer is allowed to grow and thrive. Over the last several decades it has become possible to isolate a patient’s own immune cells, expand and reactivate them in the laboratory, and use them to fight an existing cancer, termed cancer immunotherapy. We will utilize a specific immune cell, termed Natural Killer cells, and modify their genetic code to enhance their ability to treat a pre-existing osteosarcoma.

PI_NAMEs: ROBBINS, GABRIELLE MATILDE (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: Activated Natural Killer Cell;Allogenic;Antibodies;antibody-dependent cell cytotoxicity;Antigen Targeting;Antigens;Autoimmunity;Binding;Biological Assay;Bioluminescence;bioluminescence imaging;Body Weight decreased;cancer cell;cancer immunotherapy;CAR T cell therapy;CBL gene;cell killing;Cell Line;Cell Physiology;cell transformation;Cell-Mediated Cytolysis;Cells;chimeric antigen receptor;chimeric antigen receptor natural killer cells;chimeric antigen receptor T cells;Clinical;Clinical Trials;Coculture Techniques;comparison control;CRISPR/Cas technology;cytokine release syndrome;cytotoxic;cytotoxicity;Data;design;Disease;Dose;engineered NK cell;Engineering;Engraftment;ERBB2 gene;FCGR3A gene;fighting;Flow Cytometry;Generations;Genes;Genetic Code;Genetic Engineering;Genome engineering;Genomics;Goals;graft vs host disease;Health;Hematologic Neoplasms;high risk;Human;Immune;Immune system;Immunotherapy;improved;In Vitro;in vivo;in vivo evaluation;induced pluripotent stem cell;Ink;interest;Interleukin-15;interleukin-21;Interphase Cell;Knock-out;knockout gene;Label;Laboratories;Longevity;Luciferases;MADH3 gene;Malignant Neoplasms;Mediating;Membrane;Modality;Modeling;Monitor;Mus;Myeloproliferative disease;Natural Killer Cell Immunotherapy;Natural Killer Cells;neoplastic cell;neurotoxicity;next generation sequencing;NK Cell Activation;novel;Osteosarcoma;Patient-Focused Outcomes;Patients;peripheral blood;pre-clinical;Proteins;public health relevance;Publications;Reagent;receptor;Recombinant adeno-associated virus (rAAV);response;Rest;Safety;site-specific integration;Solid Neoplasm;success;System;T-Cell Receptor Therapy;T-Lymphocyte;Testing;Translating;Treatment Efficacy;treatment group;tumor;Tumor Escape;tumor microenvironment;Tumor Suppression;Western Blotting;Work;Xenograft Model

PROJECT_TITLE: Genome Engineered Natural Killer Cell Immunotherapy against Human Osteosarcoma


PI_NAMEs: RECHT, LAWRENCE D (contact)

PROJECT_TERMS: authority;Cancer Burden;Cancer Center Support Grant;Catchment Area;Child Health;Clinical Data;Clinical Protocols;Clinical Research;Clinical Trials;Conduct Clinical Trials;Data;data management;demographics;design;Discipline;Disease;Ensure;Grant;Healthcare;improved;indexing;Intervention Studies;life span;Malignant Neoplasms;Methods;Mission;Modality;Monitor;Participant;Patients;Process;Protocols documentation;Recommendation;recruit;Reporting;Research;Research Personnel;response;Review Committee;Risk;Safety;Scientific Evaluation;Standardization;Strategic Planning;study population;System;tool;women patients

PROJECT_TITLE: Protocol Review and Monitoring System


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cancer

PI_NAMEs: SEBASTIANO, VITTORIO  (contact)

PROJECT_TERMS: Algorithm Design;Animal Model;animal resource;Animals;Antibodies;Area;Biological Assay;bioluminescence imaging;Board Certification;Budgets;Cancer Biology;Cancer Center Support Grant;cancer imaging;cancer stem cell;Collaborations;comparative;cost;cost effective;cresyl violet;CRISPR/Cas technology;Cryoultramicrotomy;Custom;Data Analyses;Data Collection;design and construction;DNA;Drug Kinetics;experimental study;Fostering;Funding;Gene Modified;Genetic Engineering;genome editing;Goals;Guide RNA;Histology;Histopathology;Image;Immunohistochemistry;Inbred BALB C Mice;Institution;Knock-in;Knock-out;Knockout Mice;Laboratories;Magnetic Resonance Imaging;Malignant Neoplasms;Measurement;Mediating;Medicine;member;Modality;Modeling;mouse genome;mouse model;Mouse Strains;Oncology;oncology service;Paraffin;Pathologic;Pathologist;Pharmaceutical Preparations;Pharmacodynamics;Positron-Emission Tomography;pre-clinical;preservation;Production;programs;Protocols documentation;Publications;Research;Research Design;Research Personnel;Resource Sharing;Series;Service delivery model;Services;Sirius Red F3B;Stains;success;Surveys;Technology;Therapeutic;tissue processing;Tissues;Titrations;Transgenic Animals;Transgenic Organisms;Translating;tumor;Xenograft procedure

PROJECT_TITLE: Animal Tumor Models


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Endocrine Disruptors;Estrogen;Genetics;Nutrition;Obesity;Physical Activity;Prevention;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Among women, incidence of metabolic syndrome (MetS) increases in midlife. This study will examine the role of exposures to endocrine-disrupting chemicals found in foods and personal care products and their interaction with health behaviors such as diet, sleep and physical activity on the development and progression of MetS. The research will also consider inflammation and epigenetic changes as possible mechanisms that underlie the associations of exposures with cardiometabolic health; and can provide new knowledge to aid in prevention and management of MetS in women as they age.

PI_NAMEs: PETERSON, KAREN EILEEN (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Address;Adult;Affect;Age;Aging;Androgens;archived data;Atherosclerosis;Automobile Driving;Behavior;Biological;Biological Markers;burden of illness;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Chemical Exposure;Chromatin;Classification;cohort;Cross-Sectional Studies;Data;Development;Diet;dietary;DNA;DNA Methylation;DNA Sequence;early life exposure;Endocrine Disruptors;Environmental Exposure;Epigenetic Process;epigenome;Estrogen decline;Exposure to;Fatty acid glycerol esters;follow-up;Food;Gene Expression;Genes;Genetic Code;Glucose;Health;Health behavior;Healthcare;Heritability;High Prevalence;Hormonal Change;Hypertension;Incidence;indexing;Inflammation;Inflammatory;inflammatory marker;Knowledge;Length;Leukocytes;Life;Life Cycle Stages;Life Style;lifestyle factors;Link;Lipids;Literature;Longitudinal Studies;Measures;Menopause;Metabolic;Metabolic syndrome;Mexico;middle age;Midlife women;Mitotic;Modernization;Modification;Nature;Obesity;offspring;Outcome;Pathway interactions;personal care products;Phenols;phthalates;Physical activity;Plastics;Positioning Attribute;Postmenopause;Pregnancy;Premenopause;Prevalence;prevent;Prevention;prospective;Puberty;Research;Risk;Risk Factors;Role;senescence;Serum;Sleep;Toxic Environmental Substances;toxicant;Toxicant exposure;trend;United States;Visceral fat;Visit;Woman

PROJECT_TITLE: Metabolic Health Risk Among Mid-Life Women: The Roles of Toxicants, Inflammation, and Epigenetics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-E(02)]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Infectious complications of surgery (surgical site infection, pneumonia, urinary tract infection, and sepsis) are common, occurring in about 8% of major surgical procedures, and are costly. Currently used surveillance techniques require extensive human participation, resulting in delays of at least six months before the data are available to care providers, and the data represent only a small sample of all operations. We propose to develop a machine learning-based, near real-time recurring audit and feedback system for identification of postoperative infections that will inform providers about infectious outcomes of their patients.

PI_NAMEs: COLBORN, KATHRYN LOUISE (contact);MEGUID, ROBERT A

PROGRAM_OFFICER_NAME: MILLER, MELISSA

PROJECT_TITLE: Automated Surveillance of Postoperative Infections (ASPIN)

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


PI_NAMEs: DESAI, MANISHA  (contact)

PROJECT_TERMS: Adoption;Basic Science;biomedical informatics;Biometry;Biostatistics Shared Resource;Budgets;Cancer Center Support Grant;Clinical;Clinical effectiveness;Clinical Sciences;Clinical Trials;Clinical Trials Design;Collaborations;Data;data management;design;Development;Dose;Effectiveness;effectiveness research;Feedback;Funding;Goals;Human Resources;improved;Individual;informatics shared resource;innovation;Malignant Neoplasms;member;Mentors;Methodology;Methods;Mining;Mission;Modernization;Monitor;Nature;peer;Phase;Play;Population Sciences;programs;Protocols documentation;Publications;Randomized;Reproducibility;Research;Research Design;Research Methodology;Research Personnel;Research Technics;Resources;Review Committee;Sample Size;Scientist;sound;Statistical Data Interpretation;Statistical Methods;synergism;Techniques;Therapeutic;Training;Translational Research;translational study

PROJECT_TITLE: Biostatistics


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: RUBIN, DANIEL L (contact)

PROJECT_TERMS: anti-cancer research;Artificial Intelligence;Attention;Basic Science;Bioinformatics;biomedical informatics;Biometry;Budgets;Cancer Center;Cancer Center Support Grant;cancer clinical trial;candidate identification;Caring;Clinical;Clinical Data;Clinical Research;clinical trial recruitment;Clinical Trials;Code;Communities;Consultations;Custom;Data;Data Analyses;Data Collection;data management;Data Management Resources;data quality;data resource;Data Science;data science infrastructure;Data Sources;data tools;data visualization;Databases;Development;Disease;Education and Outreach;electronic health data;Electronic Health Record;Eligibility Determination;Enrollment;Ensure;federated learning;Fostering;Funding;Genetic;Goals;Grant;Hematologic Neoplasms;Hospitals;Image;improved;Individual;Informatics;informatics shared resource;Information Management;Information Resources;Information Retrieval;Infrastructure;Institution;Leadership;Learning;Malignant Neoplasms;member;Methods;migration;Molecular;molecular diagnostics;Monitor;Oncology;Pathology;Patients;Phase;programs;prospective;Publications;Records;Reproducibility;Research;Research Institute;Research Personnel;research study;Research Subjects;Resources;Retrieval;Review Committee;Safety;Services;Software Tools;Strategic Planning;System;Techniques;Technology;Therapeutic;Time;tool;Translational Research;Visualization;web app

PROJECT_TITLE: Biomedical Informatics


PI_NAMEs: SOLOW-CORDERO, DAVID EDWARD (contact)

PROJECT_TERMS: assay development;Biological;Biological Sciences;biological systems;Budgets;Cancer Biology;Cancer Center Support Grant;cancer stem cell;cell fixing;Cells;Charge;Chemicals;Clinical Trials;Complementary DNA;Computer software;Consultations;cost;cost effective;Data;Data Analyses;Databases;drug discovery;Drug Targeting;Ensure;Enzymes;Equipment;experience;FDA approved;Fees;Fluorescence;Fostering;Funding;Future;Genes;Genetic Screening;Genomics;Goals;Grant;Head;high throughput screening;Human;Human Genome;Image;Image Analysis;imager;imaging software;innovation;Institution;instrumentation;Investments;knock-down;Knowledge;Libraries;Liquid substance;luminescence;Malignant Neoplasms;Medicine;member;Molecular Bank;Molecular Target;mouse genome;Mus;National Center for Research Resources;new technology;novel;Open Reading Frames;Organoids;Pharmaceutical Preparations;Phase;Process;programs;Proteins;Publications;Reader;Reagent;Research;Research Personnel;Resource Sharing;Resources;Robot;scale up;screening;screening services;Services;Small Interfering RNA;small molecule;Technology;Therapeutic;Time;Training;Transfection;United States National Institutes of Health;Universities;Vendor;whole genome;Work

PROJECT_TITLE: Bioscience Screening


PI_NAMEs: LEE, JASON THANH (contact)

PROJECT_TERMS: Accounting;Animal Disease Models;animal facility;animal imaging;anti-cancer research;assay development;Biological Process;Bioluminescence;Budgets;Cancer Biology;Cancer Center Support Grant;cancer imaging;cancer immunotherapy;cancer stem cell;Consult;Cyclotrons;Data Analyses;Detection;diagnostic development;Discipline of Nuclear Medicine;Disease Progression;Doctor of Philosophy;drug development;Educational workshop;Ensure;experience;Experimental Designs;Faculty;Fluorescence;Fostering;Funding;Goals;Hematologic Neoplasms;Image;Imaging Device;imaging modality;imaging scientist;Imaging technology;Immunology;improved;in vivo;in vivo imaging;Individual;Institution;instrument;Knowledge;Laboratories;Magnetic Resonance Imaging;Magnetism;Malignant Neoplasms;Medical;Medical Imaging;member;Molecular Biology;molecular imaging;Monitor;novel diagnostics;novel therapeutic intervention;Oncology;optical imaging;particle;Physics;Play;Positron-Emission Tomography;pre-clinical research;preclinical imaging;programs;Publications;Radiobiology;Radiochemistry;Research;Research Personnel;Resource Sharing;Role;Scientist;Screening for cancer;Services;Site;Technology;theranostics;Therapeutic;Tracer;Training;Translational Research;ultrasound;Work;X-Ray Computed Tomography

PROJECT_TITLE: Cancer Imaging


PI_NAMEs: MULHOLLAND, JONATHAN W (contact)

PROJECT_TERMS: 3-Dimensional;analysis pipeline;Animals;anti-cancer research;Antibodies;Array tomography;Atomic Force Microscopy;Biological;Biomedical Engineering;Budgets;Cancer Biology;cancer biomarkers;Cancer Center Support Grant;cancer stem cell;cell type;Cells;chemical fixation;Cluster Analysis;Complement;Computer software;Cryopreservation;Data;Data Set;Development;dimensional analysis;Electron Microscope;Electron Microscopy;Electron Microscopy Shared Resource;Electrons;Engineering;fluorescence lifetime imaging;Fluorescence Microscopy;Fostering;Freezing;Funding;Goals;Image;Image Analysis;image processing;image visualization;imaging modality;imaging study;imaging system;Imaging technology;Immunofluorescence Immunologic;in vivo;Institution;instrument;invention;kartocid;Light;light microscopy;Location;Malignant Neoplasms;medical schools;member;Methods;microscopic imaging;Microscopy;Molecular;molecular imaging;molecular marker;multiplexed imaging;Negative Staining;pressure;programs;Publications;Research Personnel;Resolution;Resource Sharing;Resources;Sampling;Scanning Electron Microscopy;Schools;Science;Scientist;Services;Supporting Cell;Techniques;Technology;Temperature;Therapeutic;Three-Dimensional Imaging;tissue fixing;Tissue Microarray;Tissues;tomography;Training;transmission process;two-photon;ultra high resolution

PROJECT_TITLE: Cell Science Imaging


NIH_SPENDING_CATS: Bioengineering;Cancer

PI_NAMEs: NICHOLS, LISA A (contact)

PROJECT_TERMS: Adoption;Advanced Malignant Neoplasm;anti-cancer research;assay development;Biological Assay;Budgets;Cancer Biology;Cancer Center Support Grant;cancer immunotherapy;Cancer Patient;cancer stem cell;Cell Physiology;Cell Separation;Cells;Color;Consult;Consultations;cost effective;Data Analyses;Development;disease model;Education;Educational workshop;experience;Experimental Designs;Flow Cytometry;Flow Cytometry Shared Resource;Fostering;Funding;Generations;Genetic Medicine;Goals;Grant;Immune response;Individual;innovation;Institution;Instruction;instrument;instrumentation;Knowledge;Laboratories;Learning;Location;Malignant Neoplasms;medical schools;member;Molecular Medicine;new technology;programs;Publications;Research;Research Assistant;Research Personnel;Scientist;Services;Site;Sorting;Techniques;Technology;Time;Training;United States National Institutes of Health;Work

PROJECT_TITLE: Flow Cytometry


PI_NAMEs: COLLER, JOHN  (contact)

PROJECT_TERMS: Adopted;anti-cancer research;archive data;ATAC-seq;B-cell receptor repertoire sequencing;Bioinformatics;Biological Assay;Biological Markers;Biological Sciences;Budgets;Cancer Biology;Cancer Center Support Grant;cancer genomics;cancer immunotherapy;Cancer Research Project;cancer stem cell;cDNA Arrays;Cells;ChIP-seq;Computer Analysis;computer infrastructure;Consultations;cost;cost effective;Data Analyses;data archive;Dedications;Detection;Development;digital;Dissociation;DNA;DNA sequencing;Doctor of Philosophy;Educational workshop;Evaluation;exome;Experimental Designs;experimental study;Faculty;functional genomics;Funding;Future;Genes;Genetic;Genomics;Genomics Shared Resource;Genotype;Goals;Grant;High-Throughput Nucleotide Sequencing;Immunotherapy;Institution;Leadership;Libraries;Malignant Neoplasms;member;Messenger RNA;Metagenomics;Methods;Methylation;Microarray Analysis;MicroRNAs;Microsatellite Instability;Mutation;nano-string;nanopore;new technology;novel;Nucleic Acids;Oncology;Preparation;Process;programs;Proteins;Protocols documentation;Publications;Research;Resources;RNA;Sampling;Services;single cell genomics;single molecule;Standardization;Techniques;Technology;technology/technique;Time;Tissues;tool;Touch sensation;Training;Training and Education;transcriptome sequencing;transcriptomics;tumor;tumor DNA;Vendor;whole genome;Work

PROJECT_TITLE: Genomics


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_CITY: CAMBRIDGE

ORG_DEPT: CHEMISTRY

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: Project narrative Determining the structure of the SARS-CoV-2 envelope protein is timely for developing antiviral drugs to combat the COVID-19 pandemic. Elucidating the structure and mechanism of influenza B virus M2 proton channel is important for developing antiviral drugs against seasonal influenza infections. Determining the structures of the multidrug-resistant transporter, EmrE, is significant for preventing antibiotic resistance.

PI_NAMEs: HONG, MEI  (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: 2019-nCoV;3-Dimensional;ABCB1 gene;Acids;Address;Adopted;Affect;Amiloride;Amino Acid Sequence;Anti-viral Agents;Antibiotic Resistance;Antibiotics;antiviral drug development;Bacteria;Bacterial Infections;bacterial resistance;Binding;Binding Sites;Biological Assay;Cations;Cells;Chemicals;combat;Coupled;Couples;COVID-19 pandemic;Cytoplasm;Cytoplasmic Tail;Data;Dehydration;design;Dimensions;Drug Design;Drug Efflux;Drug Targeting;E protein;Endoplasmic Reticulum;env Gene Products;Escherichia coli;experimental study;fighting;Goals;Golgi Apparatus;H19 gene;Health;Human;Hydrophobic Interactions;improved;Infection;Inflammasome;Influenza;Influenza B Virus;influenza infection;influenza M2;influenzavirus;inhibitor;insight;Integral Membrane Protein;Ion Channel;Knowledge;Label;Length;Lipid Bilayers;Lipids;Literature;M2 protein;Measurement;Measures;Mediating;Membrane;membrane model;Membrane Proteins;Membrane Transport Proteins;mimetics;Molecular;Molecular Conformation;Motion;Multi-Drug Resistance;Multiple Bacterial Drug Resistance;mutant;nanometer;NMR Spectroscopy;novel;Organism;Pathogenicity;Pharmaceutical Preparations;Phenotype;prevent;Protein Dynamics;Proteins;protonation;Protons;Public Health;rational design;Recording of previous events;Research;Resistance to infection;Resolution;seasonal influenza;solid state nuclear magnetic resonance;Spanish flu;Structure;Techniques;Time;Transmembrane Domain;Transmembrane Transport;Vertebral column;Viral;Viral Proteins;Virus;Virus Diseases

PROJECT_TITLE: Structures and Dynamics of Proton and Cation-Dependent Channels and Transporters

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


PI_NAMEs: MAECKER, HOLDEN T. (contact)

PROJECT_TERMS: Address;anti-cancer research;Antibodies;Binding;Bioinformatics;Biological Assay;Budgets;Cancer Center Support Grant;cancer immunotherapy;Cells;Cellular Assay;Characteristics;complex data;Consultations;Custom;cytokine;Cytometry;Data;Data Analyses;data integration;Data Set;Data Storage and Retrieval;Databases;Development;Diagnosis;Fostering;Funding;Future;Genes;Goals;Hematologic Neoplasms;Human;Immune;Immune system;Immunoassay;Immunocompetence;Immunologic Markers;Immunologic Monitoring;Immunologics;Immunology procedure;Immunooncology;Immunophenotyping;improved;innovation;Institution;large datasets;Malignant Neoplasms;Measures;medical schools;member;Monitor;multidimensional data;novel;novel marker;Nucleic Acids;Phenotype;Prognosis;programs;Proteins;Publications;Quality Control;Research Personnel;Resource Sharing;RNA;Sampling;Services;single cell genomics;single cell sequencing;Standardization;Structure;T cell receptor repertoire sequencing;T-Cell Receptor;technology platform;Testing;tool;transcriptome;transcriptome sequencing;transcriptomics;treatment response;Vaccination;Visualization;Whole Blood

PROJECT_TITLE: Human Immune Monitoring


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer

PI_NAMEs: CHIEN, ALLIS SOE-LANG (contact)

PROJECT_TERMS: Address;anti-cancer research;Antibodies;Antibody-drug conjugates;Antineoplastic Agents;Aptitude;Area;Biological;Biological Assay;biomarker discovery;Budgets;Cancer Biology;Cancer Center Support Grant;cancer stem cell;Chemicals;Clinical;clinically relevant;cohort;Communication;Communities;Complex;Computer software;Consultations;crosslink;Crystallization;Custom;Data;data access;Data Analyses;data archive;data exchange;Data Files;design;Development;Doctor of Philosophy;drug discovery;Drug Kinetics;Education;empowerment;experience;Experimental Designs;Fostering;Funding;Future;Genomics;Goals;Health Services Research;improved;Institution;instrument;instrumentation;Investments;Knowledge;Laboratories;Language;Licensing;Ligation;Malignant Neoplasms;mass spectrometer;Mass Spectrum Analysis;member;Metabolism;method development;Methodology;Methods;Modernization;Molecular Target;Outcome;Pathway interactions;Persons;Post Translational Modification Analysis;Preparation;programs;Proteins;Proteomics;Proteomics Shared Resource;Protocols documentation;Publications;Reproducibility;Research;Research Personnel;Research Support;Resource Sharing;Resources;Sampling;Scientist;Series;Services;sharing platform;Signal Transduction;small molecule;Software Tools;System;Techniques;Technology;Therapeutic;Training;transcriptomics;Update;user-friendly;Walking;Water

PROJECT_TITLE: Proteomics


ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE In the US, approximately 1 in every 2-3 individuals will develop cancer, a disease of uncontrolled cellular proliferation that can be fatal. The TP53 gene is the most commonly mutated gene in human cancer, reflecting the fact that p53 plays an essential role as a tumor suppressor. This research aims to elucidate the mechanisms by which p53 acts to suppress cancer, with the ultimate goal of improving early detection and treatment of cancer.

PI_NAMEs: ATTARDI, LAURA D (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Acute;Affect;Alternative Splicing;Alveolar;Biological Assay;cancer cell;cancer therapy;carcinogenesis;Cell Differentiation process;Cell Proliferation;Cells;CRISPR screen;Disease;DNA Damage;Early Diagnosis;Early treatment;Event;Evolution;Genes;Genetic Transcription;Goals;Human;improved;in vivo;Individual;insight;Kinetics;KRASG12D;Lung Adenocarcinoma;lung injury;lung regeneration;Malignant Neoplasms;Mediating;Molecular;mouse model;Mus;Mutant Strains Mice;Mutate;novel;Pathway interactions;Play;posttranscriptional;Primary carcinoma of the liver cells;programs;Proteome;Proteomics;Research;response;RNA Splicing;RNA-Binding Proteins;Role;single cell ATAC-seq;single-cell RNA sequencing;small hairpin RNA;standard of care;targeted treatment;Testing;Therapeutic;TP53 gene;Transcriptional Activation Domain;tumor;tumor barcoding and sequencing;tumor microenvironment;Tumor Suppression;Tumor Suppressor Genes;Tumor Suppressor Proteins;Work;Zinc Fingers

PROJECT_TITLE: Integrative approaches to elucidate p53 transcriptional networks during carcinogenesis


PI_NAMEs: HOWITT, BROOKE E (contact)

PROJECT_TERMS: Accountability;Achievement;anti-cancer research;Area;Autopsy;biobank;Biological Assay;Blood;Blood Banks;Blood specimen;Budgets;Cancer Biology;Cancer Center Support Grant;cancer genomics;Cancer Model;Cancer Patient;cancer stem cell;Cell Survival;Cells;cellular imaging;Clinic;Collaborations;Confidentiality of Patient Information;Consent;Consent Forms;Data;data access;data integration;Databases;Electronics;Ensure;experience;Flow Cytometry;Formalin;Fostering;Freezing;Fresh Tissue;Funding;Genetic;Genomics;Goals;Histologic;histological stains;Human;human tissue;Immunoassay;Immunologic Monitoring;improved;individual patient;Institution;Institutional Review Boards;Joints;Link;Malignant Neoplasms;member;Modeling;molecular imaging;neoplasm registry;Normal tissue morphology;Operative Surgical Procedures;Organoids;Paraffin Embedding;Pathologic;Pathologist;Patients;Precision Health;Process;programs;Protocols documentation;Publications;Radiation Oncology;Regulation;Research;Research Institute;Research Personnel;Resource Sharing;Services;single-cell RNA sequencing;Source;Specimen;Stains;Standardization;stem;surgery material;Surgical Pathology;Suspensions;Technology;Therapeutic;Tissue Banks;Tissue Embedding;Tissue Procurements;Tissue Sample;Tissues;Tumor Tissue

PROJECT_TITLE: Tissue Procurement


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hematology;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Cancer is a frequent diagnosis in the emergency department (ED); ED cancer diagnoses are more common among minority and low income patients and result in poor outcomes, including lower survival. Evidence about emergency diagnosis of cancer in the United States (U.S.), and how to prevent it from occurring, is limited. This study will generate much needed evidence about this important problem, including who is affected, where, and why, illuminating a largely unrecognized issue to help identify modifiable drivers of disparities in patients with the poorest prognoses.

PI_NAMEs: THOMPSON, CAROLINE AVERY (contact)

PROGRAM_OFFICER_NAME: BURNETT, ANDREA NICOLE

PROJECT_TERMS: Accident and Emergency department;Affect;Age;American;Awareness;Black race;Bladder;Breast;Cancer Burden;Cancer Control;cancer diagnosis;cancer epidemiology;cancer health disparity;Cancer Patient;cancer type;Caring;Characteristics;Chronic;Clinical;Colon;Colon Carcinoma;Colorectal;comorbidity;Complex;Country;curative treatments;Data;Diagnosis;Diagnostic;Disadvantaged;Disparity;Early Intervention;Emergency Department Physician;Emergency department visit;Emergency Medicine;Emergency Situation;Epidemiologic Methods;Epidemiology;Esophagus;ethnic minority;Ethnic Origin;Etiology;evidence base;Family Practice;follow-up;Future;Geography;Goals;health care delivery;health care service utilization;Healthcare;help-seeking behavior;improved;improved outcome;Income;Inequity;innovation;Insurance Coverage;Kidney;Knowledge;Latino;lens;leukemia;Life;Liver;Low income;Lung;Malignant Breast Neoplasm;Malignant neoplasm of esophagus;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Malignant Neoplasms;malignant stomach neoplasm;Marital Status;Mediating;Medical Sociology;Medicare;Minority;Minority Groups;minority patient;Modality;Multiple Cancer Sites;Multiple Myeloma;Non-Hodgkin's Lymphoma;Oncology;Outcome;outcome disparities;Ovary;Pancreas;Patient Discharge;patient navigation;patient population;Patients;Pattern;Patterns of Care;Policies;Population;population based;Population Study;Predictive Factor;Prevalence;prevent;Prevention;Prevention strategy;primary care provider;primary care setting;Prognosis;prognostic;Prostate;Provider;Quality of Care;Race;racial disparity;racial minority;Rectal Cancer;Rectum;Renal Carcinoma;Research;Research Design;Risk Factors;routine screening;Rural;rural residence;screening;Screening for cancer;Socioeconomic Status;Source;Stomach;survival disparity;Symptoms;therapy development;Time;Training;Trauma;tumor;Underserved Population;United States;Unmarried;Uterine Cancer;Uterus;Visit;Vulnerable Populations

PROJECT_TITLE: Diagnosis of Cancer in the Emergency Room - Explaining Persistent Disparities

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Pediatric

ORG_DEPT: PSYCHOLOGY

ORG_NAME: HARVARD UNIVERSITY

PHR: NARRATIVE The proposed research examines neurodevelopmental mechanisms underlying the powerful association of stressful life events (SLEs) with internalizing and externalizing psychopathology during adolescence. We use a novel methodological approach that permits examination of dynamic changes in emotion, cognition, social behavior, and neural function and connectivity following SLEs at a sufficiently fine grained level of temporal specificity to identify mechanisms underlying the link between SLEs and adolescent psychopathology as they unfold in real time. Elucidating these mechanisms will not only build knowledge of how environmental experience shapes development in ways that increase risk for psychopathology, but will also suggest possible targets for interventions to prevent the onset of stress-related psychopathology in children and adolescents.

PI_NAMEs: MCLAUGHLIN, KATIE  (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Acceleration;Address;Adolescence;Adolescent;Affect;Affective;Age;Amygdaloid structure;Behavior;Behavioral;Cellular Phone;Child;Cognition;Cognitive;cognitive control;cohort;Cross-Sectional Studies;Cues;design;Development;Developmental Process;digital phenotyping;Dorsal;Emotional;emotional stimulus;Emotions;Etiology;experience;Exposure to;Female;Frequencies;Goals;Grain;improved;Individual;innovation;Institution;Institutionalization;Intervention;Knowledge;Lead;Life Cycle Stages;Link;longitudinal design;Longitudinal Studies;Maps;Measures;media use;Mediating;Mental disorders;Mental Health;Methodology;Methods;Monitor;negative affect;Negative Valence;neglect;neural;neural circuit;neuromechanism;Neurophysiology - biologic function;novel;novel strategies;Onset of illness;Pattern;peer;Performance;Physical activity;Positive Valence;prevent;Prevention;Process;prospective;Psychopathology;Research;Research Domain Criteria;response;Rest;Rewards;Risk;sex;Shapes;sleep behavior;sleep quality;sleep quantity;smartphone based device;social;Social Behavior;social engagement;social media;Social Processes;Specificity;Stress;Stressful Event;Symptoms;System;Technology;Telephone;Text;Theoretical model;Time;Variant;Ventral Striatum;Violence;wearable device;Work;Youth

PROJECT_TITLE: Neurodevelopmental Mechanisms Underlying Stress Vulnerability during Adolescence

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: DC

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Hearing Loss;Neurodegenerative;Neurosciences

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Project Narrative Because not all listeners process speech in the same way, it is important to understand how variation in the types of information (cues) that individuals tend to rely on to interpret speech relates to experiences with age-related hearing loss. This proposal tests the hypothesis that individual differences in cue use explain variation in speech comprehension in older adults with mild age-related hearing loss above and beyond just their hearing abilities. Understanding the mechanisms behind different experiences with emerging age-related hearing loss will help inform treatment plans and improve quality of life.

PI_NAMEs: CRINNION, ANNE MARIE (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Acoustics;Adult;Affect;aged;Aging;Audiology;aural rehabilitation;Awareness;behavior measurement;Behavioral;Brain;Caring;Categories;Cognitive;cognitive ability;Compensation;Comprehension;Cues;Data;design;effective therapy;Electroencephalography;Environment;Event-Related Potentials;experience;experimental study;Goals;Hearing;hearing impairment;Hearing Tests;improved;Individual;Individual Differences;insight;Lead;Length;lens;Link;Maps;Measures;Methods;neural;Neurobiology;neuroimaging;Noise;older adult;Outcome Measure;Panthera leo;Participant;Patients;Pattern;Perception;Peripheral;Persons;Phonetics;predictive modeling;predictive signature;preference;Presbycusis;Process;Quality of life;repaired;Reporting;Research;resilience;response;Running;Semantics;Signal Transduction;Speech;speech in noise;Speech Perception;standard measure;Testing;theories;Training;treatment planning;Variant;Word Processing;Work;young adult

PROJECT_TITLE: Understanding Individual Differences in Acoustic-Phonetic and Contextual Cue Use In Aging


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: Nuclear Pore Complex (NPC) components (Nups) been shown to play a role in tissuespecific development and in several human pathologies, including cardiac disorders and hematologic malignancies, but how Nups contribute to development and to these serious conditions remains poorly understood. We have identified a function of Nups as scaffolds for genome organization, which helps direct appropriate gene expression. The goal of this proposal is to define molecular mechanisms, by which Nups set up genome organization and regulate genes, which will provide new avenues for understanding pathologies and developmental processes linked to the NPC.

PI_NAMEs: CAPELSON, MAYA  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Affect;Architecture;Binding;Biology;Cell Nucleus;Cells;Chromatin;chromatin immunoprecipitation;Chromatin Structure;chromosome conformation capture;Complex;Cytoplasm;Deposition;Development;Developmental Gene;Developmental Process;Distant;DNA;driving force;Drosophila genome;Ecdysone;Elements;embryonic cell culture;Enhancers;Environment;epigenetic memory;Epigenetic Process;Event;experimental study;Exposure to;fly;Future;Gene Activation;Gene Expression;Gene Expression Regulation;Gene Silencing;Genes;Genetic Transcription;Genome;genome-wide;Genomics;Goals;Heart Diseases;Hematologic Neoplasms;Histones;Homeobox Genes;Hormones;Human Pathology;Immunoprecipitation;Investigation;Knowledge;Link;Macromolecular Complexes;Maintenance;Mediating;Memory;Methods;Molecular;Nuclear;Nuclear Envelope;Nuclear Matrix;Nuclear Pore;Nuclear Pore Complex;Nuclear Pore Complex Proteins;nucleocytoplasmic transport;Pathology processes;Pathway interactions;Phenotype;Play;Polycomb;promoter;Proteins;recruit;Regulation;response;Role;scaffold;Testing;Tissues;Transcriptional Activation;Transcriptional Regulation

PROJECT_TITLE: Nuclear Pore Complexes As Scaffolds For Genome Architecture And Epigenetic Maintenance

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics

ORG_CITY: HOUSTON

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative In this proposal, we expect to define the PTHrP-PTH1R pathway as a potential therapeutic target for severe tooth eruption disorders involving molars, which arise from genetic and pharmacological disturbance in tooth eruption. These findings will provide foundations for future human clinical trials and applications of SIK inhibitors to treat patients suffering from compromised quality of life due to failure of tooth eruption in molars.

PI_NAMEs: ONO, WANIDA  (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: 3-Dimensional;Adjuvant Therapy;Affect;Alleles;alveolar bone;autocrine;bisphosphonate;bone;bone mass;Cell Line;Cells;Clinical;clinical application;Clinical Trials;Cyclic AMP;Cyclic AMP Receptor Protein;Cyclic AMP-Dependent Protein Kinases;Dental Sac;dentin matrix protein 1;Dentition;Disease;Failure;Foundations;functional restoration;Future;Gene Deletion;Genetic;Genetic Diseases;Goals;Histologic;Human;in vivo;Injections;innovation;kinase inhibitor;LoxP-flanked allele;Malignant Neoplasms;microCT;Modality;mouse model;Mus;mutant;novel;novel therapeutic intervention;novel therapeutics;Nuclear Translocation;Orthodontic;Osteoblasts;Osteogenesis;Osteogenesis Imperfecta;Outcome;parathyroid hormone-related protein;Pathway interactions;Patients;pediatric patients;pharmacologic;Phenotype;protein expression;Quality of life;receptor;Receptor Signaling;Reporter;response;Role;salt-inducible kinase;Signal Induction;Signal Pathway;Signal Transduction;Signaling Protein;skeletal;small molecule;Structure;Tamoxifen;Testing;therapeutic target;Time;Tooth eruption;Tooth root structure;Tooth structure;transcriptome sequencing;transcriptomics;Zoledronic Acid

PROJECT_TITLE: Pharmacological rescue of tooth eruption disorders

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Despite substantial efforts aimed at increasing faculty diversity, the proportion of faculty at academic institutions from underrepresented groups is well below their proportional representation in the U.S. population. The San Diego Leading the Advancement of Underrepresented Neuroscientists for Change (LAUNCH) program aims to enhance the diversity of the biomedical workforce in neuroscience. Junior faculty and postdoctoral fellow participants in LAUNCH will obtain strong mentorship, career skills, and excellent guidance in research training and grantsmanship, that will improve their success in developing neuroscience research programs and in obtaining research funding.

PI_NAMEs: REZNIK, VIVIAN ;TREJO, JOANN  (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Academic skills;Acceleration;Adult;Advanced Development;Affect;African American;Alzheimer's disease related dementia;American;Area;Award;base;Biomedical Research;black men;California;career;career development;Career Mobility;Categories;Censuses;Child;Client satisfaction;Clinical Research;cohort;Collaborations;Communication;Development;Diagnosis;disability;disabled;Disabled Persons;Disease;Disparity;Diverse Workforce;Doctor of Philosophy;ethnic minority;ethnic minority population;Ethnic Origin;evidence base;experience;Extramural Activities;Faculty;faculty research;Fellowship Program;Fostering;Funding;General Population;Goals;graduate student;Grant;Hispanic Populations;Home;Immersion;improved;Individual;Institution;K-Series Research Career Programs;Knowledge;medical schools;member;men;Mentors;Mentorship;Minority Groups;minority trainee;Minority Women;Modeling;Molecular;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurosciences;Neurosciences Research;Participant;Patients;Physicians;Population;post-doctoral training;Postdoctoral Fellow;Prevalence;Professional Competence;Program Development;programs;Publications;Race;racial minority;racial minority population;Recording of previous events;recruit;Reduce health disparities;Research;research and development;Research Personnel;Research Project Grants;Research Training;Scholars Program;Scientist;Self Efficacy;skill acquisition;skills;Stroke;stroke therapy;Structure;success;System;tenure track;Training;Training Programs;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;visiting scholar;Woman;Writing

PROJECT_TITLE: San Diego Leading the Advancement of Underrepresented Neuroscientists for Change (LAUNCH) Program


ADMINISTERING_IC: TR

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PI_NAMEs: GOLDMAN, JENNIFER LYNN;SOSNOFF, JACOB J. (contact)

PROGRAM_OFFICER_NAME: KRASNOVA, IRINA N

PROJECT_TERMS: Acceleration;Address;career;Clinical;Clinical Research;cohort;Collaborations;Communities;Competence;Complement;Dedications;Degree program;Development Plans;Discipline;Educational Curriculum;Ensure;Environment;ethnic diversity;Evaluation;Exclusion;experience;frontier;Funding;Future;Grant;Infrastructure;innovation;Institution;Maps;Master of Science;Mentors;Mentorship;Methods;Midwestern United States;Motivation;multidisciplinary;National Research Service Awards;Nature;novel;Patients;Population;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;programs;Qualifying;Race;recruit;Research;Research Personnel;Resources;Science;Scientist;skills;success;TNFSF15 gene;Training;Training Activity;training opportunity;Training Programs;Translational Research;Work;Workforce Development;workforce needs

PROJECT_TITLE: NRSA Training Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: AUGUSTA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative: Reactive oxygen species (ROS) play an important role in the process of new blood vessel growth in ischemic heart and limb diseases. This proposal will advance the field to understand molecular mechanism through which ROS are involved in postnatal angiogenesis via regulation of endothelial cell metabolism. This application will also provide strong impact to discover novel therapeutic targets and strategies for treatment of various angiogenesis-dependent cardiovascular diseases.

PI_NAMEs: USHIO-FUKAI, MASUKO  (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: 5'-AMP-activated protein kinase;Address;AMP-activated protein kinase kinase;angiogenesis;Animal Model;Biological Assay;Biosensor;Biotin;Blood Vessels;Cardiovascular Diseases;Cell Separation;Cellular Metabolic Process;CRISPR/Cas technology;cysteinesulfenic acid;Cytosol;Data;Diabetes Mellitus;diabetic;Disease;disulfide bond;Endothelial Cells;Endothelium;Enzymes;Fractionation;Future;Gene Transfer;Glycolysis;Goals;Grant;Growth;Guanosine Triphosphate Phosphohydrolases;Hindlimb;Human;Hydrogen Peroxide;Impairment;In Situ;in situ imaging;in vivo;innovation;insight;Ischemia;KDR gene;Knock-in;Knock-in Mouse;Label;Ligation;limb ischemia;Link;Measures;Metabolic;Metabolism;Methods;Mitochondria;Modeling;Molecular;Mus;Muscle;mutant;Mutant Strains Mice;Myocardial Ischemia;NADPH Oxidase;neovascularization;new therapeutic target;novel;Outer Mitochondrial Membrane;overexpression;oxidation;Oxidation-Reduction;Oxidative Phosphorylation;Patients;Peripheral arterial disease;Phase;Phosphorylation;Physiological;Play;Post-Translational Protein Processing;postnatal;Process;Production;Protein Dynamics;protein protein interaction;Proteins;Reactive Oxygen Species;Reagent;real-time images;Regulation;Reporting;response;response to injury;Role;Sampling;sensor;Signal Transduction;Signaling Molecule;Site;Source;therapeutic angiogenesis;therapeutic target;tissue repair;Transgenic Mice;transmission process;treatment strategy;Vascular Diseases;Vascular Endothelial Growth Factors

PROJECT_TITLE: Mitochondria Dynamics Protein Drp1 in ROS Signaling, Endothelial Metabolism and Angiogenesis

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Mental Illness;Neurosciences;Schizophrenia

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Cognitive memory deficits are highly debilitating symptoms in schizophrenia. We propose the first attempt to comprehensively describe and understand cellular, molecular and microcircuit pathomechanisms of schizophrenia risk mutation-related episodic memory deficits in a genetic mouse model of schizophrenia. We will use cutting-edge, high-resolution recording and manipulation technologies in the hippocampal circuitry of behaving mice. These approaches are likely to yield major insights into the principles by which cellular, molecular and microcircuit alterations lead to cognitive memory dysfunctions associated with schizophrenia.

PI_NAMEs: GOGOS, JOSEPH A;LOSONCZY, ATTILA  (contact)

PROGRAM_OFFICER_NAME: MANDELBLAT-CERF, YAEL

PROJECT_TERMS: 22q11.2;Address;Adult;Affect;Animal Model;Area;associated symptom;Automobile Driving;Axon;Behavior;Behavioral;Biological;Biological Models;cell type;Cells;Cognitive;Cognitive deficits;cognitive task;Coupled;Data;debilitating symptom;DiGeorge Syndrome;Disease;disease model;Dissection;Dorsal;Employment;entorhinal cortex;Episodic memory;episodic memory impairment;Etiology;Event;Exhibits;Functional disorder;Functional Imaging;Gene Expression Profile;Gene Expression Profiling;Generations;Genetic;Genetic Risk;genetic risk factor;Genetic study;Goals;Head;Heterogeneity;Hippocampus;Image;Impaired cognition;Impairment;in vivo;Individual;insight;Interneurons;Knowledge;Lead;learned behavior;Learning;locus ceruleus structure;Mediating;Memory;Memory impairment;Mental disorders;Molecular;mouse model;multimodality;Mus;Mutant Strains Mice;Mutation;neural;Neurons;neuropsychiatric disorder;neuroregulation;Neurosciences;noradrenergic;novel;optogenetics;patch sequencing;Patients;Pharmacogenetics;Physiological;Physiological Processes;Play;Population;Process;Property;Psychoses;Pyramidal Cells;recruit;Regulation;Resolution;Rewards;Risk;Rodent;Role;Schizoaffective Disorders;Schizophrenia;schizophrenia risk;Sensory;Symptoms;Synaptic plasticity;Techniques;Technology;transcriptomics;Transgenic Mice;two-photon;virtual reality environment

PROJECT_TITLE: Microcircuit, cellular and molecular dissection of impaired hippocampal function in a mouse model of the 22q11.2 deletion

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ORG_CITY: CHICAGO

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Maternal mortality and severe maternal morbidity (SMM) continue to rise in the United States, and women from low-income communities, minoritized racial/ethnic groups, and those with Medicaid or who are uninsured face increased risk. This study will combine quantitative Medicaid claims and qualitative key informant analyses to examine the potential impact of preconception care in reducing maternal SMM, particularly for women at highest risk.

PI_NAMEs: STULBERG, DEBRA  (contact)

PROGRAM_OFFICER_NAME: CHEW, EMILY

PROJECT_TITLE: Effects of Preconception Care on Maternal Outcomes in Medicaid

STUDY_SECTION: HSVR

STUDY_SECTION_NAME: Healthcare Systems and Values Research[HSVR]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Overall - Narrative The VDDRC, through technologies provided by innovative Research Cores and financial and professional support of junior and seasoned investigators, seeks to improve the prevention, treatment and outcomes of human digestive diseases by serving as a catalyst for collaborative and impactful investigative research.

PI_NAMEs: PEEK, RICHARD M. (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Academy;animal imaging;Area;Award;base;Biological;Biometry;Cancer Center;career;career development;catalyst;cellular imaging;Clinical;Collaborations;Communities;cost effective;Coupled;Cryoelectron Microscopy;design;Development;Diabetes Mellitus;dietary;Digestive System Disorders;digital;Discipline;Disease;Elements;Engraftment;Environment;Extramural Activities;Faculty;falls;Flow Cytometry;Foundations;Funding;gastrointestinal infection;Gastrointestinal Injury;Genus Mentha;Histology;Human;Immunology;improved;Infection;Inflammation;Infrastructure;innovation;innovative technologies;Institution;interest;Intervention;Investments;Journals;Knowledge;Lesion;Light;Link;Mass Spectrum Analysis;member;Metabolism;microbial;microbiome;Microscopy;minority investigator;Mission;Molecular;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Natural regeneration;next generation;nutrition;Obesity;Occupational activity of managing finances;Online Systems;operation;Pathogenesis;Patients;Peer Review;Physicians;premalignant;Prevention;Productivity;programs;Proteomics;Publications;Publishing;recruit;Research;Research Activity;Research Personnel;Resources;Science;Seasons;Services;skills;stem cells;Surgeon;Surveys;symposium;Technology;tool development;Training;Transcend;Translating;treatment and outcome;Underrepresented Minority;United States National Institutes of Health;Visit;Work

PROJECT_TITLE: Molecular and Cellular Basis for Digestive Diseases


NIH_SPENDING_CATS: Digestive Diseases

PROJECT_TERMS: Academy;Address;Award;base;Basic Science;Biometry;Budgets;Cancer Center;career development;clinical investigation;Clinical Research;Collaborations;Communication;cost;Data Analyses;Database Management Systems;design;Development;Diabetes Mellitus;Digestive System Disorders;Disease;Ensure;Expenditure;Feedback;flexibility;Fostering;Funding;gastrointestinal;Gastrointestinal Diseases;Goals;Grant;Human Resources;Immunology;Infection;Inflammation;Infrastructure;innovation;Institution;Investigation;Investigator-Initiated Research;Investments;large datasets;Leadership;Medicine;meetings;member;Metabolism;Methodology;minority investigator;Modeling;Molecular;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;nutrition;Obesity;Occupational activity of managing finances;operation;Pilot Projects;Productivity;Program Development;programs;Publications;Reporting;Research;Research Design;Research Personnel;Research Support;sabbatical;Science;Scientist;Seasons;Series;Services;skills;Structure;Surveys;Technology;tool development;Training;Underrepresented Minority;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Precision Medicine

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Narrative Predictive personalized healthcare and precision medicine based on both traditional physiological information and modern clinical spatial imaging biomarkers would provide an accurate disease prediction and personalized treatment plan. This proposed project will develop a personalized spatial data-driven computational modeling framework to analyze these clinical biomarker data and will also validate this approach on various diseases. The successful research will have a huge impact to reveal a more comprehensive disease assessment and a new therapeutic approach to optimize the available treatment plans for each individual.

PI_NAMEs: HAO, WENRUI  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: 3-Dimensional;Alzheimer's Disease;analytical tool;Area;Biological;Calibration;Cardiovascular Diseases;chronic pancreatitis;Clinical;clinical biomarkers;Clinical Data;Clinical Medicine;Clinical Trials;computational platform;Computer Models;Computing Methodologies;Data;Data Analyses;Data Analytics;Disease;Disease Progression;disorder risk;Epidemiology;Functional disorder;Genetic;Goals;Healthcare;Image;imaging biomarker;Individual;innovation;mathematical model;Medicine;Modeling;Modernization;novel therapeutic intervention;optimal treatments;Patients;personalized approach;personalized health care;personalized medicine;personalized predictions;Physiological;precision medicine;Research;Research Project Grants;Science;Signal Pathway;Suggestion;Techniques;Technology;Time;treatment planning;usability;virtual;Vision

PROJECT_TITLE: A pathophysiology driven spatial dynamic modeling framework for personalized prediction and precision medicine


PI_NAMEs: TYSKA, MATTHEW J (contact)

PROJECT_TERMS: Acceleration;Achievement;Capital;career development;Cell Physiology;cellular imaging;Computer software;Confocal Microscopy;Consultations;cost;Cost Savings;Custom;Data Analyses;Dedications;Digestive System Disorders;digital imaging;Disease;Educational Models;Electron Microscope;Electron Microscopy;Ensure;Equipment;Experimental Designs;experimental study;Fee-for-Service Plans;Funding;Goals;Grant;Human Resources;Image;Image Analysis;imaging capabilities;Imaging technology;in vivo imaging;Individual;innovation;Institution;instrument;Laboratories;Laser Scanning Confocal Microscopy;Light;Light Microscope;Literature;member;Microscope;microscopic imaging;Microscopy;Modernization;Molecular;multidisciplinary;Optics;organizational structure;Peer Review;Preparation;prevent;Publications;Quality Control;Research;Research Personnel;Research Support;Resource Sharing;Resources;Sampling;Scanning Electron Microscopy;Services;Specimen;Subcellular Anatomy;superresolution microscopy;Surveys;System;Techniques;technology development;Time;Tissues;Training;Transmission Electron Microscopy;two photon microscopy

PROJECT_TITLE: Cell Imaging Core


ORG_CITY: IOWA CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: The immune system provides humans with critically important protective responses to infectious pathogens such as viruses and bacteria, as well as to tumor cells; but inappropriate immune responses can also cause inflammation and autoimmune diseases. Studies that advance understanding of immune responses, and how to apply this knowledge to preventing and treating human diseases have great potential to reduce the disease burden and promote the health of the nation. The Predoctoral Training Program in Immunology is designed to provide rigorous training in a supportive environment for graduate students to pursue multiple approaches to understanding the mechanisms underlying immune responses, and apply this knowledge toward the treatment of human disease.

PI_NAMEs: BISHOP, GAIL A.;LEGGE, KEVIN L (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


PI_NAMEs: SKAAR, ERIC P (contact)

PROJECT_TERMS: Adipose tissue;Antibodies;Applications Grants;Biological Assay;career development;catalyst;Cell Nucleus;Cell Separation;Cells;cellular imaging;Collaborations;Color;Complement;Computer software;Consultations;cost;Data;Data Analyses;design;Detection;Development;Digestive System Disorders;Disease;Doctor of Philosophy;Elements;Equipment;experience;Experimental Designs;experimental study;fabrication;Flow Cytometry;Funding;gastric organoids;Gastrointestinal tract structure;Genomics;Goals;high dimensionality;Hour;Individual;innovation;Institution;instrument;instrumentation;Intestines;Manufacturer;Master of Public Health;member;Modification;Molecular;multidisciplinary;new technology;Peer Review;Preparation;Protocols documentation;Publications;Recommendation;Research;Research Personnel;Resource Sharing;response;Sampling;Services;single cell analysis;skills;Sorting;Techniques;Technology;Tissues;Training;Training Activity;Training Programs;transcriptome sequencing;United States National Institutes of Health;Work

PROJECT_TITLE: Flow Cytometry Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Clinical Research;Digestive Diseases

PI_NAMEs: WASHINGTON, MARY KAY (contact)

PROJECT_TERMS: Address;animal imaging;Animal Model;animal tissue;Animals;Archives;Biological Models;career development;Collaborations;Custom;Data Analyses;Decentralization;design;Digestive System Disorders;digital;digital imaging;Dimensions;Disease;Evaluation;Fluorescence;fluorescence imaging;Fostering;Funding;gastrointestinal;Gastrointestinal Diseases;Goals;high throughput analysis;Histologic;histological specimens;histological stains;Histology;Histopathology;Human;human disease;human tissue;Image;image translation;Imaging Device;imaging modality;imaging probe;imaging science;imaging scientist;Immunofluorescence Immunologic;Immunohistochemistry;Individual;innovation;Investigation;Isotopes;Label;Laboratories;mass spectrometric imaging;member;Methods;Modality;Modeling;Molecular;molecular imaging;morphological criteria;Morphology;multidisciplinary;non-invasive imaging;optical imaging;Optics;Organoids;Peer Review;Positron;pre-clinical;Pre-Clinical Model;pre-clinical research;preclinical imaging;Production;Publications;Reagent;Recording of previous events;Research;Research Personnel;Resolution;response;Services;single photon emission computed tomography;Slide;Surrogate Markers;Tissue Microarray;Tissue Sample;Tissue Stains;Tissues;Training;Transgenic Model;Universities;Validation;Washington;whole slide imaging;Work

PROJECT_TITLE: Translational Analysis Core


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

ORG_CITY: SAINT LOUIS

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE – Overview The Washington University Center for Diabetes Translation Research (WU-CDTR) supports research on the root causes of diabetes inequities informed by the social determinants of health. The Center includes five novel Translational Research Cores: Dissemination and Implementation in Diabetes Research; Policy and Systems Science Analysis; Health Communication and Social Needs; Health Informatics in Diabetes Research (Regional Resource); and Solutions to Diabetes in Black Americans (National Resource); and sponsors a Pilot and Feasibility Program and an Enrichment Program. The WU-CDTR enhances efficiency, productivity, and rapid research translation across a national network of investigators while fostering collaborations to achieve diabetes health equity.

PI_NAMEs: HAIRE-JOSHU, DEBRA  (contact)

PROGRAM_OFFICER_NAME: ARTIS DICKERSON, SHAVON

PROJECT_TERMS: American Indians;Area;Arts;Award;Awareness;base;biobehavior;Black American;Black race;Caring;Clinical Sciences;Collaborations;Communities;community engagement;community partners;community research;design;Development;Diabetes Mellitus;diabetes risk;Direct Costs;Discipline;Disparity;Dissemination and Implementation;Education;education research;efficacious intervention;Environment;Equity;ethnic minority;Event;evidence base;Evidence based intervention;Fostering;Foundations;Funding;Goals;Grant;Health;health care settings;health communication;health equity;health management;Healthcare;Home;implementation research;Inequity;innovation;Intervention;Knowledge;medical schools;member;Mentors;Minority Groups;minority investigator;Mission;Missouri;next generation;novel;nutrition;Obesity;Pennsylvania;Policies;Policy Research;Population;Population Heterogeneity;Populations at Risk;Productivity;programs;Public Health;Public Health Informatics;racial minority;Research;Research Personnel;Research Support;Resources;Rural;scale up;Schools;Science;Scientist;Services;skills;social;social health determinants;socioeconomic disadvantage;Source;Strategic vision;Students;synergism;System;systems research;Technology;Translating;translational pipeline;Translational Research;Translations;Underrepresented Minority;United States National Institutes of Health;Universities;Vision;Washington;Work;World Health


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases

PI_NAMEs: SCHEY, KEVIN L (contact)

PROJECT_TERMS: analytical method;Bioinformatics;Biological Assay;career development;Complex;Computers and Advanced Instrumentation;Consultations;cost effective;Coupled;Data;Data Analyses;Development;Digestive System Disorders;Disease;Doctor of Philosophy;Elements;Equipment;Experimental Designs;Facility Accesses;Funding;Goals;Human Resources;Inductively Coupled Plasma Mass Spectrometry;innovation;instrument;instrumentation;Isotopes;Laboratories;Lipids;mass spectrometer;mass spectrometric imaging;Mass Spectrum Analysis;member;metabolomics;method development;Methods;microbial;Mission;Molecular;Molecular Profiling;Monitor;multidisciplinary;operation;Peer Review;Peptides;Pharmaceutical Preparations;Post-Translational Protein Processing;Preparation;Proteins;Proteome;Proteomics;Publications;Reporting;Research;Research Personnel;Running;Sampling;Services;small molecule;Tissue imaging;Tissues;Training;Training Programs

PROJECT_TITLE: Mass Spectrometry/Proteomics Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Complementary and Integrative Health;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: QUEENS

ORG_NAME: ST. JOHN'S UNIVERSITY

PHR: Project Narrative  Early music and language experiences produce structural and functional changes in the brain, however, the impact of such experiences, especially the interaction of the two has not been fully explored in children. The proposed research uses the combination of a music neurophysiological paradigm and a lexical tone neurophysiological paradigm to examine the influence of early music training, early tonal versus non-tonal bilingual acquisition and dialect experience on different aspects of music feature processing, as well as to determine the complex interaction between music training and language acquisition on the neural network for music and speech processing. Findings may lead to the development of new approaches that utilize music to treat developmental language disorder and neurological disorders.

PI_NAMEs: YU, YAN HELEN (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: 10 year old;Acoustics;Address;Adolescent;Adult;African American;Age;age group;American;Auditory;auditory processing;base;Behavior;behavior measurement;Behavioral;behavioral outcome;behavioral response;bilingualism;Birth;Brain;Child;Childhood;Clinical;Cognition;Complex;Development;developmental plasticity;early childhood;Event-Related Potentials;experience;Goals;improved;interest;Language;Language Development;Language Development Disorders;Learning;lexical;Linguistics;Literature;Location;Mainstreaming;Music;Nervous System;Nervous System Disorder;neural;neural network;neurodevelopment;Neurologic;neuromechanism;neurophysiology;Neurophysiology - biologic function;novel strategies;Periodicity;Physiology;Pitch Perception;Population;Process;remediation;Research;Resource Sharing;response;Rest;skills;Slide;Spanish/English;Speech;speech processing;Speech Sound;Stress;Time;Training

PROJECT_TITLE: Deciphering the neural mechanisms of music processing in the developing brain: A multi-feature and multi-cultural comparison


NIH_SPENDING_CATS: Diabetes

PROJECT_TERMS: Achievement;Advisory Committees;Annual Reports;Area;base;Black race;Collaborations;Communication;Diabetes Mellitus;diabetes risk;Disparity;diversity and inclusion;Effectiveness;efficacious intervention;Ensure;evidence base;Foundations;Funding;Goals;Guidelines;Health;health equity;Leadership;Location;Maintenance;meetings;member;Mission;Missouri;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;operation;Populations at Risk;Positioning Attribute;prevent;Process;Productivity;programs;Publications;Research;Research Activity;Research Personnel;Resources;response;Science;Services;Strategic vision;Structure;success;Translating;Translational Research;United States National Institutes of Health;Universities;Update;Vision;Washington;web site


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases

PI_NAMEs: WILSON, KEITH T. (contact)

PROJECT_TERMS: Academy;Alabama;Atlases;Award;Basic Science;Cancer Center;career;career development;Cells;Cellular biology;cellular imaging;Clinical Research;Collaborations;Crohn's disease;data repository;Developmental Biology;Diabetes Mellitus;Digestive System Disorders;Direct Costs;Disease;Doctor of Medicine;Doctor of Philosophy;Enrollment;Environment;Fostering;Foundations;Friends;Funding;Future;Gastroenterology;Goals;Grant;Growth;Guidelines;Immunology;Infection;Inflammation;innovation;Institution;Investigation;Investments;Leadership;Master of Public Health;Medicine;member;Microbiology;mid-career faculty;Molecular;multidisciplinary;Operative Surgical Procedures;Pathology;Positioning Attribute;professor;programs;Publications;recruit;Reproducibility;Research;Research Personnel;Research Project Grants;senior faculty;Talents;Teacher Professional Development;tenure track;Testing;Training;Translational Research;Trust;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Pilot and Feasibility Program


NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: The need for well-trained scientists to conduct impactful research on epidemiologic, clinical and translational aspects of kidney disease is substantial. The T32 Kidney Disease Epidemiology Training Program at Johns Hopkins has a stellar reputation for identifying and training researchers who can meet this need.

PI_NAMEs: CREWS, DEIDRA CANDICE (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TITLE: Renal Disease Epidemiology Training Grant

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


PROJECT_TERMS: Academy;Award;Biology;Cancer Center;career;career development;design;Development;Digestive System Disorders;Disease;Elements;Endowment;Epithelium;Faculty;Fostering;Funding;Gastroenterology;Genus Mentha;Gnotobiotic;Goals;Immunology;Infection;Inflammation;innovation;Institution;interest;International;Intervention;Knowledge;Laboratories;lectures;member;Modeling;Molecular;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;Physicians;posters;programs;Research;Research Personnel;sabbatical;Series;Students;Surgeon;symposium;Targeted Research;Techniques;Technology;tool;tool development;Training;Training Programs;Transcend;Underrepresented Minority;United States;virtual;Visit;voucher;Work

PROJECT_TITLE: Enrichment Program


NIH_SPENDING_CATS: Diabetes;Dissemination and Implementation Research;Prevention

PI_NAMEs: BROWNSON, ROSS C (contact)

PROJECT_TERMS: Acceleration;Address;Applications Grants;Clinical;Clinical Services;Communities;community setting;design;Development;diabetes management;Diabetes Mellitus;Diabetes prevention;Dissemination and Implementation;dissemination science;effective intervention;Ensure;Environment;Equity;Evaluation;Event;experience;Fostering;Funding;Goals;Growth;health equity;implementation framework;implementation research;implementation science;implementation strategy;implementation study;implementation tool;improved;innovation;Instruction;Intervention;Interview;Knowledge;Lead;Libraries;Manuscripts;Measures;Methods;Mission;novel;online resource;Online Systems;Patients;Phase;Population;population health;preference;Prevention;Procedures;Process;Recording of previous events;Research;Research Design;Research Methodology;Research Personnel;Research Support;research to practice;Resources;Science;Services;skills;social health determinants;stakeholder perspectives;therapy design;Translational Research;Translations;Universities;uptake;Washington;web-based tool;webinar

PROJECT_TITLE: DIDR-Dissemination & Implementation in Diabetes Research


ADMINISTERING_IC: AR

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Clinical Research;Disability Research;Physical Rehabilitation;Rehabilitation;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: LEXINGTON

ORG_DEPT: OTHER CLINICAL SCIENCES

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative Patients surviving critical illness acquire impairments in muscle and physical function that can persist for years after hospital discharge. The planned study will identify cellular and physical function outcomes that contribute to failed muscle regrowth in the recovery phase of critical illness. My training will entail statistical analyses for basic and applied science and the experiments to assess human skeletal muscle to determine cellular mechanisms that drive impairments in muscle and contribute to sustained physical functional deficits.

PI_NAMEs: MAYER, KIRBY P (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Acceleration;Acute respiratory failure;Address;Adult;Applied Research;Basic Science;Biogenesis;Biopsy;Cell Physiology;cell type;Cells;Characteristics;Chronic disability;Clinical;Clinical Investigator;Clinical Sciences;Clinical Trials;comparison control;Complex;COVID-19;Critical Illness;Data;Deuterium Oxide;Development;disabled;effective therapy;Environment;experimental study;Functional disorder;Functional impairment;functional outcomes;Future;Gait speed;Goals;Grant;Growth;Health;Hospitalization;Hospitals;Human;Immunohistochemistry;Impairment;improved;Inflammatory;inflammatory milieu;Intensive Care Units;Intervention;Knowledge;Knowledge acquisition;Label;Learning;Long term physical disability;longitudinal analysis;Lower Extremity;Macrophage;Measures;Mechanical ventilation;Mentors;Mentorship;Methodology;Microscopy;Mitochondria;Mitochondrial Proteins;Morphology;Muscle;Muscle Fatigue;muscle form;Muscle function;muscle progenitor cell;Muscle Proteins;Muscle satellite cell;muscle strength;Muscle Weakness;novel;Outcome;patient subsets;Patient-Focused Outcomes;Patients;Pattern;Performance;pharmacologic;Phase;Phenotype;Physical Function;physical impairment;Physical Rehabilitation;physically handicapped;prevent;Property;Protein Biosynthesis;protein degradation;Proteins;Proteolysis;proteostasis;Quality of life;Recovery;Recovery of Function;Regression Analysis;rehabilitation research;rehabilitation strategy;Rehabilitation therapy;Research;Respiration;Ribosomes;RNA;Sepsis;Severity of illness;Skeletal Muscle;skeletal muscle wasting;skills;Stable Isotope Labeling;Statistical Data Interpretation;stem;Survivors;Technical Expertise;Testing;Time;Training;Translating;Walking;Western Blotting

PROJECT_TITLE: Cellular and Physical Function Outcomes Leading to Failed Muscle Recovery After Critical Illness

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Data Science;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: WILCOX, ADAM BENJAMIN (contact)

PROJECT_TERMS: Address;analytical method;Area;Chronic Disease;Clinical;Collaborations;Communities;Consult;Consultations;Country;Data;Data Science Core;diabetes management;Diabetes Mellitus;Diabetes prevention;diabetes self-management;disparity reduction;Dissemination and Implementation;Economics;Environmental Impact;Evaluation;experience;Expert Systems;Focus Groups;Fostering;frontier;Funding;Goals;Health;health equity;health equity promotion;Health Policy;improved;innovation;interest;Interest Group;Intervention;Knowledge;Leadership;Link;member;Methods;Modeling;next generation;novel;Outcome;Policies;Policy Analysis;Policy Research;Prevention;Research;Research Design;Research Methodology;Research Personnel;Research Support;Risk Factors;Science;Scientist;Services;Structure;System;Systems Analysis;systems research;Targeted Research;Techniques;Translating;Translational Research;Universities;Washington;Work

PROJECT_TITLE: AI and Data Science Core


NIH_SPENDING_CATS: Cancer;Cardiovascular;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Heart Disease;Hematology;Orphan Drug;Patient Safety;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases;Transplantation

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Data on cardiac function following treatment for relapsed pediatric acute myeloid leukemia (AML) are poorly captured on frontline treatment trials and thus the natural history of cardiotoxicity in pediatric AML is incompletely understood and the impacts of early toxicity on treatment selection upon relapse and subsequent impacts on outcomes have not been evaluated. The proposed project will establish a unique data resource by merging Children's Oncology Group clinical trial data, electronic health record data, longitudinal standard of care echoes, and administrative data from the Pediatric Health Information System that will allow us to address these significant knowledge gaps. Given that nearly 50% of AML patients experience relapse, and relatively poor prognosis of recurrent disease, a better understanding of the toxicity risks associated with salvage therapies and the impact on effectiveness is critical for improving AML outcomes.

PI_NAMEs: GETZ, KELLY DIRINGER (contact)

PROGRAM_OFFICER_NAME: KETEMA, FASSIL

PROJECT_TERMS: Acute Myelocytic Leukemia;Address;Adolescent;adverse outcome;Cardiomyopathies;Cardiotoxicity;chemotherapy;Chemotherapy-Oncologic Procedure;Child;Childhood;Childhood Acute Myeloid Leukemia;clinical development;Clinical Trials Cooperative Group;Clinical Trials Database;cohort;Computerized Medical Record;conditioning;Data;data resource;Diagnosis;Disease;Disease remission;Disease-Free Survival;Echocardiography;Effectiveness;Electronic Health Record;Evaluation;experience;follow-up;functional decline;Functional disorder;Goals;graft vs host disease;Health Information System;Heart failure;heart function;Impact evaluation;improved;improved outcome;Incidence;Injury;Institution;Knowledge;Left;Left Ventricular Function;leukemia treatment;Long Term Survivorship;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;Mediating;Mediator;Morbidity - disease rate;mortality;Muscle Cells;Myocardial dysfunction;Natural History;Outcome;Patients;Pediatric Oncology Group;Phenotype;prevent;Probability;Prognosis;Recovery;Recurrent disease;Refractory;Refractory Disease;Regimen;Relapse;Risk;Salvage Therapy;Selection for Treatments;Source;standard of care;Standardization;Stem cell transplant;Supportive care;survival outcome;Survivors;Time;Toxic effect;Transplantation;treatment effect;Treatment outcome;treatment risk;treatment trial;Variant;Ventricular;Work

PROJECT_TITLE: Treatment-Related Cardiotoxicity in Children with Relapsed Acute Myeloid Leukemia - Natural History, Occurrence and Implications

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Development and Maintenance of the Animal Feed Regulatory Program Standards (AFRPS) (U18) PAR-20- 132 will enable the Office of Indiana State Chemist (OISC) to develop a risk-based feed safety program, establish a uniform foundation for the design, management, measurement, and improvement of the program and enhance the programmatic objective to protect public health through the regulation of animal feed. Through the implementation of the AFRPS, OISC will improve upon directing regulatory activities toward reducing foodborne illness attributed to feed safety hazards in animal feed materials and feed supply facilities.

PI_NAMEs: DUNN, PATRICIA  (contact)

PROGRAM_OFFICER_NAME: LITTRELL, KEITH


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: BUFFALO

ORG_NAME: HAUPTMAN-WOODWARD MEDICAL RESEARCH INST

PHR: PROJECT NARRATIVE Structural biology is an area of research that seeks to understand the physical architecture of biological macromolecules, providing important information about how those molecules operate in health and disease states. The primary tool used for molecular structure determination is X-ray crystallography, but progress in crystallography is limited by the difficult obstacle of coaxing biological molecules into crystalline forms. We propose a national crystallization resource, the HTX Center, that builds on our existing crystallization center and infrastructure at HWI, with enhanced capabilities in computing, experimental pipelines, and user engagement that are geared to not just continuing to offer state-of-the-art macromolecular crystallization services to the scientific community, but also to expand access to advanced instrumentation and expertise to help researchers overcome this primary bottleneck in macromolecular crystallography.

PI_NAMEs: BOWMAN, SARAH ELIZABETH JOHNSON (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Address;analysis pipeline;Architecture;Area;beamline;Biological;Chemicals;Communities;computer infrastructure;Computer software;computerized tools;Computers and Advanced Instrumentation;cost;Coupled;Crystallization;Crystallography;Deposition;design;detector;Development;Disease;drug development;Ensure;Equipment;experimental study;flexibility;Funding;Goals;Government;Growth;Health;high throughput screening;Image;Image Analysis;image processing;Imaging technology;improved;Infrastructure;innovation;insight;instrument;instrumentation;Laboratories;Link;Liquid substance;macromolecule;Medical Research;Metadata;Methods;Molecular Structure;National Institute of General Medical Sciences;operation;Outcome;outreach;Process;protein data bank;Protocols documentation;Qualifying;repository;Research;Research Institute;Research Personnel;Resource-limited setting;Resources;Robotics;Roentgen Rays;Sampling;scale up;Science;screening;screening services;Services;Source;structural biology;Structure;success;System;Technology;tool;United States National Institutes of Health;X ray diffraction analysis;X-Ray Crystallography

PROJECT_TITLE: National HTX Center: Enabling Access to State-of-the-Art Crystallization Capabilities


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Neurosciences

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: Project Narrative Despite differences in the prevalence of psychiatric disorders between males and females, the reasons remain elusive. We seek to understand how sex hormones affect the ways that neurons function, ultimately changing behavior.

PI_NAMEs: JUNTTI, SCOTT ALAN (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Adult;Affect;Aggressive behavior;Behavior;behavior change;Biological Models;Brain;Cells;Cichlids;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Development;Endocrine system;experimental study;Female;Foundations;Gene Expression;gene network;Gene Transfer Techniques;Genes;Genetic Transcription;Genome;Genomics;Goals;Gonadal Hormones;Gonadal Steroid Hormones;hormonal signals;Hormones;hypothalamic pituitary gonadal axis;Incidence;insight;Ligands;male;Mediating;men;Mental disorders;neural circuit;Neural Pathways;Neurons;Neurophysiology - biologic function;neuropsychiatry;Pattern;Population;Prevalence;Production;Progesterone Receptors;Progestins;programs;Prostaglandins;receptor;Receptor Signaling;Reproductive Behavior;Research;sensory input;sex;Shapes;Signal Transduction;Smell Perception;Social Behavior;Social Controls;Stereotyping;steroid hormone receptor;Steroids;System;Technology;Time;transcription factor;Vertebrates;Woman

PROJECT_TITLE: Dissecting sex hormone effects on genes, neurons, and behavior using cichlid fish

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: KREUTER, MATTHEW W. (contact)

PROJECT_TERMS: Acute;Address;African American population;Audience Research;Black Populations;care systems;Child Care;Communication;Communication Research;community partnership;Comprehension;Consultations;Data;design;diabetes management;Diabetes Mellitus;Diabetes prevention;disparity reduction;Effectiveness;Employment;Equity;experience;Food;food security;Health;health communication;health disparity;health disparity populations;health equity;health goals;health inequalities;health literacy;Health Priorities;Hispanic Populations;Housing;improved;Individual;Intervention;Knowledge;Latino Population;Measures;Methodology;Misinformation;novel strategies;Outcome;Policies;Population;Population Intervention;preventive intervention;prototype;Public Housing;Research;Research Design;Research Methodology;Research Personnel;Resources;Rural Population;Safety;safety net;Security;Services;skills;social;social health determinants;Social Work;socioeconomic disadvantage;Subgroup;System;Testing;Translating;Translational Research;Transportation;Universities;virtual group;virtual library;Washington;webinar

PROJECT_TITLE: HCSN-Health Communication & Social Needs


ORG_CITY: Columbus

ORG_DEPT: NEUROSURGERY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Arterial thrombosis, which results in acute ischemic stroke (AIS) affects ~15 million worldwide each year, and although rtPA reduces morbidity and mortality, AIS patients treated with rtPA develop restenosis, poor recanalization, and symptomatic hemorrhage. We developed an RNA aptamer (DTRI-031) that binds to and inhibits Von Willebrand Factor (VWF), critical in thrombus formation AND designed a specific reversal agent DTRI-025, that provides a critical measure of safety currently lacking in AIS treatment. This work will establish the importance of VWF as an optimal target in AIS patients, demonstrate that DTRI-031 rapidly and efficiently lyses arterial clots formed from AIS patient blood that is readily reversed by DTRI-025, and show that DTRI-031 improves recovery in a pre-clinical model of AIS with a favorable safety profile compared to rtPA.

PI_NAMEs: NIMJEE, SHAHID  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acute;Adhesions;Affect;Affinity;Age;Age Factors;aged;Alteplase;Animal Model;aptamer;Architecture;Area;artery occlusion;Autologous;behavior test;Binding;Biological Specimen database;Blood;Blood - brain barrier anatomy;Blood coagulation;Blood Platelets;Blood specimen;Caring;Carotid Artery Thrombosis;Cell Adhesion;Cerebral Edema;Cerebral Thrombus;Cerebrum;Cessation of life;Clinical;clinical database;Coagulation Process;comparison control;Complex;Cytolysis;Data;design;disability;effective therapy;Encapsulated;Endothelium;endovascular thrombectomy;Erythrocytes;Event;Factor VIII;Fibrin;Fibrinolytic Agents;functional improvement;functional outcomes;Genetic;Glycoproteins;Goals;Hemorrhage;Hour;Hypertension;hypertensive;improved;improved outcome;In Vitro;in vivo;Infarction;injured;innovation;Institution;Intracranial Hemorrhages;Ischemic Stroke;Laser Speckle Imaging;Ligands;Magnetic Resonance Imaging;Measures;Mechanics;Mediating;Mediator;Morbidity - disease rate;mortality;mouse model;Mus;novel;Oligonucleotides;Outcome;Patients;Pharmaceutical Preparations;Plasma;Platelet Activation;Platelet aggregation;Play;post stroke;Pre-Clinical Model;prevent;Process;Production;programs;Proteins;receptor;Recovery;Recovery of Function;Resistance;restenosis;revascularization;Risk;RNA;Role;Safety;scaffold;Severities;sex;Specificity;Stroke;stroke incidence;stroke intervention;stroke model;stroke patient;stroke symptom;stroke therapy;Testing;Thrombectomy;Thrombin;thromboembolic stroke;Thromboembolism;thrombolysis;Thrombosis;Thrombus;Time;Translating;Translational Research;von Willebrand Factor;Work

PROJECT_TITLE: A novel thrombolytic targeting Von Willebrand Factor (VWF) to treat ischemic stroke

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Complementary and Integrative Health;Natural Products;Networking and Information Technology R&D (NITRD)

ORG_CITY: RICHLAND

ORG_NAME: BATTELLE PACIFIC NORTHWEST LABORATORIES

ORG_STATE: WA

PHR: PROJECT NARRATIVE The Natural Products Magnetic Resonance Database (NP-MRD) will be an electronically accessible data repository allowing key information about the world’s natural products to be openly shared and rapidly queried by the global scientific community. It will be particularly important for those scientists using Nuclear Magnetic Resonance (NMR) spectroscopy to study natural products to study or discover new natural products that may one day be used to improve health or cure disease. The NP-MRD will become an important hub for all natural product chemists around the world, allowing them to share their data, to learn from each other, and to accelerate the translation of their discoveries to benefit humanity.

PI_NAMEs: CORT, JOHN R (contact)

PROGRAM_OFFICER_NAME: STILL, PATRICK COLBY

PROJECT_TERMS: Acceleration;Agreement;Animals;Archaea;Archives;Atlases;Bacteria;Chemicals;Classification;cloud based;Cloud Computing;Communities;community engagement;community-centered;Complement;Complex Mixtures;Computer software;computing resources;Consensus;Crude Extracts;Data;data archive;data exchange;data format;data integrity;data quality/integrity;data repository;data sharing;Data Storage and Retrieval;data submission;Databases;density;Deposition;design;digital object identifier;Disease;Ensure;expectation;experimental study;FAIR principles;Frequencies;fungus;Gene Cluster;Goals;Harvest;Health;heuristics;Hour;Human;Humanities;Image;improved;Individual;interactive tool;interoperability;Intuition;Journals;Learning;Letters;Link;Literature;Magnetic Resonance;marine organism;Mass Spectrum Analysis;Media Campaign;metabolome;metabolomics;Metadata;Methods;Mining;Molecular;National Center for Complementary and Integrative Health;Natural Products;Newsletter;NMR Spectroscopy;novel;Nuclear Magnetic Resonance;Online Systems;open data;open source;outreach;Paper;Plants;Policies;Printing;Privatization;Process;Protocols documentation;public database;Publications;quantum;query tools;Reporting;repository;Research;Resolution;Resources;Retrieval;Running;Scientific Societies;Scientist;simulation;Sister;Site;social;social media;Social Network;Software Tools;Source;Structure;Summary Reports;symposium;Taxonomy;Techniques;Text;theories;Time;tool;Traction;Training;Translations;user-friendly;Validation;Vendor;Visualization;Visualization software;web site;web-enabled;webinar;Work

PROJECT_TITLE: NP-MRD: Natural Products Magnetic Resonance Database