NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Palliative Care;Precision Medicine;Prevention

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Prolonged intensive care unit (ICU) stays are devastating, expensive, psychologically and ethically challenging for providers, patients and families, and disproportionally burdensome to healthcare systems. Traditional risk- prediction models have failed to identify patients at risk of prolonged ICU stays early in their ICU course, hindering advancements in the implementation of evidenced-based practices to prevent its development. This proposal aims to leverage physician knowledge in building better risk prediction models by prospectively and retrospectively surveying physicians and evaluating hospital factors which contribute to the development of a prolonged ICU stay.

PI_NAMEs: VIGLIANTI, ELIZABETH MARIE (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Achievement;acute hypoxemic respiratory failure;Admission activity;American;Austria;Automobile Driving;Award;Bed Occupancy;Beds;Bioethics;biomarker identification;career;career development;Caregivers;Caring;Chest;Clinical;Clinical stratification;Cognitive;cohort;Consult;cost;COVID-19 pandemic;Critical Care;Critical Illness;Data;Data Analyses;Data Set;Decision Making;design;Development;Development Plans;Distress;Ethics;Event;evidence base;Evidence based practice;experience;Family;Funding;Goals;Grant;Healthcare Systems;heuristics;high risk;Hospital Mortality;Hospitals;Hour;improved;Institution;Intensive Care Units;Interview;K-Series Research Career Programs;Knowledge;Learned Helplessness;lecturer;Longitudinal cohort;Longitudinal Surveys;Lung;Manuscripts;Medical;Medical center;Medicine;Mental Depression;Mentored Clinical Scientist Development Program;Mentors;Methodology;Michigan;Minority;Morbidity - disease rate;National Heart, Lung, and Blood Institute;North Carolina;Organ failure;Outcome;palliative;Palliative Care;Paper;Patient Admission;Patient Care;patient stratification;patient subsets;Patients;Peer Review;Physicians;Population;predictive tools;Prevalence;prevent;Prevention;Probability;Process;professor;Prognosis;prognostication;prospective;Prospective cohort;Provider;psychologic;Publications;Publishing;Research;Resources;response;Risk;risk prediction;risk prediction model;risk stratification;Scientist;Scotland;Shock;social;Societies;Source;Structure;Survey Methodology;Surveys;Symptoms;System;systematic review;Universities;Validation;Variant;Veterans Health Administration;Work;Writing

PROJECT_TITLE: Improving Risk-Stratification in Patients with Prolonged ICU Stays


ADMINISTERING_IC: MD

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Contraception/Reproduction;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: Los Angeles

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PI_NAMEs: FARZAN, SHOHREH F (contact)

PROJECT_TERMS: Acculturation;Air Pollutants;Air Pollution;ambient air pollution;Birth;blood lipid;Blood Pressure;Body mass index;California;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular effects;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Caring;Chronic;Chronic Disease;cohort;Communities;Country;Data;Development;disadvantaged women;Environment;Environmental Exposure;Environmental Risk Factor;environmental stressor;Epigenetic Process;experience;Exposure to;Fetus;follow-up;Gene Targeting;Gestational Diabetes;gestational weight gain;Glucose Intolerance;Glycosylated Hemoglobin;Glycosylated hemoglobin A;Health;health disparities in women;health disparity populations;Hispanic;Hispanic Women;Homeostasis;Hypertension;Inflammation;Language;late life;Link;Lipids;Maternal Exposure;Maternal Health;Mediating;MicroRNAs;Minority Groups;Modification;Mothers;Pathway interactions;Physiological Adaptation;Pollution;Population;post pregnancy;postpartum care;Postpartum Period;Pre-Eclampsia;Predisposition;preference;Pregnancy;Pregnancy Complications;prenatal;prenatal environmental exposure;prenatal exposure;prepregnancy;Prevalence;Prevention;prospective;Psychosocial Stress;psychosocial stressors;Recommendation;Research;Risk;Risk Factors;Role;social;social stressor;sociodemographics;socioeconomic disadvantage;stressor;Testing;Urban Community;virtual;Waist-Hip Ratio;Woman;Work

PROJECT_TITLE: Project 2: Maternal Exposure to Environmental and Psychosocial Stressors and Cardiovascular Risks after Pregnancy


ADMINISTERING_IC: HG

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: CAMBRIDGE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: PROJECT NARRATIVE Single cell sequencing technologies are incredible tools for characterizing differences in the sequence of cells in a heterogeneous sample. Many questions on the frontier of genomics consider not only the difference in the sequence of these cells, but also how the sequence encodes differences in the phenotype of the cells. This work aims to develop a novel sequencing technology that can simultaneously profile the phenotype and sequence of individual cells, opening the door to entirely new research questions previously unaddresable.

PI_NAMEs: THAKUR, ROHAN  (contact)

PROGRAM_OFFICER_NAME: FUFA, TEMESGEN D

PROJECT_TERMS: Acceleration;Address;Antibodies;Attention;Back;Bar Codes;Behavior;behavioral phenotyping;Biological;biological research;Cancer Biology;cell behavior;Cell Separation;Cells;Cellular Morphology;Clinical;Communicable Diseases;Complex;Custom;Data;Data Set;Development;Developmental Biology;Disease;DNA;dosage;Elements;Engineering;epigenome;Fluorescence;Fluorescent Antibody Technique;frontier;Gene Expression Profile;Genetic;Genome;Genomics;Goals;Hand;Individual;interest;Libraries;Link;Maps;Membrane Proteins;Methods;Microfluidics;microscopic imaging;Microscopy;multiple datasets;multiple omics;novel;novel sequencing technology;Optics;Pathology;Phenotype;Photobleaching;Plasmids;Proteome;Research;Resolution;RNA Sequences;Sampling;Scheme;sequencing platform;Signal Transduction;single cell sequencing;single cell technology;single-cell RNA sequencing;synthetic biology;System;Systems Biology;targeted sequencing;Technology;technology platform;technology validation;Time;tool;transcriptome;transcriptomics;Work

PROJECT_TITLE: Developing an ultra-high throughput droplet microfluidic workflow for genetic circuit characterization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Regenerative Medicine;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_CITY: IRVINE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Temporomandibular joint (TMJ) condyle degeneration affects approximately 50M Americans, and tissue- engineered implants have the potential to regenerate osteochondral defects on the TMJ condyle. This proposal will characterize the TMJ condyle of the Yucatan minipig, engineer neocartilage-bone implants with robust interfacial properties, and regenerate osteochondral defects of the TMJ condyle in a large minipig model. Successful completion of this proposal will enhance translation of neocartilage-bone implants toward human use by showing safety and efficacy in an in vivo model, modeled after FDA preclinical definitive animal studies.

PI_NAMEs: BIELAJEW, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Adult;Affect;Age;American;analog;Animal Model;Animals;Arthralgia;articular cartilage;Benchmarking;Biochemical;Biochemistry;Biological Assay;Biomechanics;Biomimetics;bone;bone marrow mesenchymal stem cell;Bone Morphogenetic Proteins;bone scaffold;calcification;Cartilage;cartilage implant;Cartilage Matrix;cartilage regeneration;Clinic;Clinical;Clinical Trials;Collagen Type I;Collagen Type II;Collagen Type X;condylar cartilage;Data;Defect;Degenerative polyarthritis;design;Engineering;experimental study;Faculty;Failure;Fibrocartilages;Financial Support;Funding;Glycerophosphates;Goals;Gold;Histologic;Histology;Human;Hyaline Cartilage;Immunohistochemistry;Implant;improved;in vivo;in vivo Model;interfacial;Intervention;Life;Liquid substance;Mandibular Condyle;Maps;mass spectrometric imaging;mechanical properties;mechanical stimulus;Mechanics;Mentors;Mesenchymal Stem Cells;Methodology;Methods;Miniature Swine;Modeling;Morphology;Natural regeneration;novel;Operative Surgical Procedures;osteochondral tissue;Patients;Phase;Population;Positioning Attribute;Postdoctoral Fellow;pre-clinical;prevent;Process;Property;Proteomics;Reporting;Research;Safety;self assembly;Spatial Distribution;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Structure of articular disc of temporomandibular joint;success;Techniques;Temporomandibular Joint;Temporomandibular Joint Disorders;Tensile Strength;Time;Tissue Engineering;tissue regeneration;Tissues;tool;Training;Translations;Triiodothyronine;Universities

PROJECT_TITLE: Tissue-engineered regeneration of the minipig TMJ condyle

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: HABRE, RIMA  (contact)

PROJECT_TERMS: Acculturation;Address;Adrenal Glands;Affect;Age;Air Pollution;allostasis;allostatic load;Body System;cardiovascular disorder risk;Cardiovascular system;Characteristics;Chemicals;Child;Chronic;Cognitive;cohort;Country;Crime;demographics;deprivation;Development;Disadvantaged;Disease;Disparity population;disparity reduction;Environment;Environmental Exposure;Environmental Hazards;Environmental Health;environmental health disparity;Environmental Impact;Environmental Risk Factor;environmental stressor;ethnic difference;ethnic disparity;ethnic minority;Ethnic Origin;Exposure to;Frequencies;Geography;hazard;Health;health care service utilization;health disparity;health of the mother;Healthcare;Hispanic Populations;Hispanic Women;Household;Hypothalamic structure;Immune;improved;Individual;Inflammation;Investigation;Joints;Language;Lead;Life Cycle Stages;Los Angeles;Low income;low socioeconomic status;Maternal Exposure;Maternal Health;maternal morbidity;Maternal Mortality;Measures;Mental Depression;Metabolic;Modeling;Neighborhoods;Neurosecretory Systems;Onset of illness;Outcome;Pattern;Physiological;Physiology;Pituitary Gland;Policies;postpartum care;postpartum health;Postpartum Period;Poverty;Predisposition;Pregnancy;psychosocial stressors;Race;racial difference;racial disparity;racial minority;residence;Residential Mobility;response;Risk;Risk Factors;Signal Transduction;social;social disparities;social stressor;socioeconomics;Stress;stressor;System;Time;Woman

PROJECT_TITLE: Project 3: Maternal Exposure to Environmental Hazards and Psychosocial Stressors and Postpartum Allostatic Load


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative Our laboratory has recently discovered that high cell density quorum sensing signaling promotes a symbiosis between V. cholerae and the model arthropod host Drosophila melanogaster. In particular, the high cell density master regulator HapR activates interactions of V. cholerae with the host intestine that are normally attributed to intestinal symbionts including increased host innate immune signaling, digestion of the mucus-like peritrophic matrix synthesis, and host tryptophan metabolism. Here we seek to elucidate the host and pathogen regulatory pathways that engender this response. These findings will expand our appreciation of the role of quorum sensing in the persistence of the human pathogen V. cholerae and will establish new paradigms for metabolic communication between intestinal pathogens and their hosts.

PI_NAMEs: WATNICK, PAULA I (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: Acetates;Arthropods;Bacteria;bacterial genetics;Cell Density;cell type;Central Nervous System;Chitinase;Cholera;Cholera Toxin;chromatin remodeling;Communication;Complex;Data;Diarrhea;Dietary Supplementation;Digestion;Drosophila genus;Drosophila melanogaster;enteric pathogen;Enzymes;Epidemic;Epidemiology;Epithelial Cells;epithelial repair;Epithelium;experimental study;Extracellular Space;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Models;Genetic Transcription;genomic tools;Goals;Growth;gut microbes;Homeostasis;Human;human pathogen;Immune;Immune signaling;Infection;Innate Immune Response;Insecta;insulin signaling;intestinal epithelium;Intestines;Investigation;knock-down;Kynurenine;Laboratories;life span;Lipids;Mammals;Measures;Mediating;Membrane;membrane synthesis;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Microbe;microbial;Modeling;Mucous body substance;Natural Immunity;Nutrient;Organism;Outcome;pandemic disease;pathogen;Pathway interactions;Peptide Hydrolases;Peripheral;Pilum;Play;programs;quorum sensing;Regulation;Regulatory Pathway;Reporting;Repression;response;Role;Serotonin;Signal Pathway;Signal Transduction;Steroids;symbiont;Symbiosis;Thinness;TNF gene;Toxin;transcription factor;transcriptome sequencing;Tryptophan;Tryptophan 5-monooxygenase;Tryptophan Metabolism Pathway;Vibrio cholerae;Virulence;Virulence Factors;Work

PROJECT_TITLE: Vibrio cholerae quorum sensing as an intestinal symbiosis factor in a model arthropod host

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Pain;Interstitial Cystitis;Pain Research;Urologic Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Urological Chronic Pelvic Pain Syndrome (UCPPS) is a debilitating condition of men and women with unknown causes. We will use state-of-the-art chemical analyses of urine from patients to improve diagnostics, better understand the causes of UCPPS, and improve treatment.

PI_NAMEs: HENDERSON, JEFFREY P (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Address;Affect;Biochemical;Biological;Biological Assay;Biological Markers;candidate marker;Chemicals;Chronic;chronic pain patient;Chronic pain syndrome;chronic pelvic pain;Chronic Prostatitis;Clinical;Clinical Management;clinical phenotype;Clinical Trials;cohort;Collection;cost;Data Analyses;Data Analytics;Data Scientist;debilitating symptom;Detection;Diagnosis;Diagnostic;Dietary intake;effective therapy;end stage disease;Enrollment;Ensure;Etiocholanolone;Etiology;experience;Female;Frequencies;Functional disorder;Goals;Health Care Costs;Human;improved;instrumentation;interdisciplinary approach;Interdisciplinary Study;Interstitial Cystitis;Isomerism;Knowledge;Link;liquid chromatography mass spectrometry;Mass Spectrum Analysis;Mathematics;men;Metabolism;metabolomics;microbiome;micturition urgency;multimodality;National Institute of Diabetes and Digestive and Kidney Diseases;new therapeutic target;novel diagnostics;novel therapeutic intervention;Opitz trigonocephaly syndrome;Outcome;Pain;Pain Disorder;pain symptom;Patient Care;patient population;patient subsets;Patients;Pattern;Pelvic Pain;Phenotype;Physicians;Physiological Processes;Population;Process;Quality of life;Research;sample collection;Sampling Studies;Sensitivity and Specificity;Site;small molecule;Specimen;steroid metabolism;Steroids;study population;Subgroup;Sulfate;Symptoms;Testing;Testosterone;therapeutic development;treatment response;Update;urinary;Urine;urologic;urologic chronic pelvic pain syndrome;Variant;Woman;women subjects;Work

PROJECT_TITLE: Metabolomic Signatures of Urologic Chronic Pelvic Pain Syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-R(90)]


NIH_SPENDING_CATS: Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Pediatric;Pediatric - AIDS;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE The burden of perinatal HIV-1 infections remains high despite remarkable advances in prevention. The PAVE Collaboratory will accelerate progress towards developing strategies to achieve virus eradication and/or sustained viral remission after cessation of antiretroviral therapy. We plan to address the knowledge gaps relevant to the control and eradication of persistent HIV-1 infection among pediatric populations that are currently a barrier to ART-free remission and cure.

PI_NAMEs: CHAHROUDI, ANN M;PERSAUD, DEBORAH  (contact)

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: 15 year old;Acceleration;Active Immunization;Address;adenovirus mediated delivery;Adherence;Adolescent;Adolescent and Young Adult;Adult;Aftercare;Age;aged;Antibody Therapy;antiretroviral therapy;Award;Binding;Biological Markers;Biological Models;Biology;career development;Characteristics;Child;Childhood;Clinical;Clinical Research;Clinical Trials;cohort;Collaborations;collaboratory;combat;Communities;community engagement;community partners;cost;Country;Data;Development;Disease remission;efficacy clinical trial;efficacy evaluation;Epidemic;Epigenetic Process;Ethics;Evolution;Exhibits;Faculty;Feedback;Fostering;Future;Gender;Generations;Goals;HIV;HIV-1;Human;Image;imaging modality;Immune;Immune system;Immune Targeting;Immunity;Immunization;Immunologic Markers;Immunologics;Immunotherapeutic agent;industry partner;Infant;infant infection;Infection;insight;International;Interruption;Intervention;Intervention Trial;Investigation;Knowledge;latent HIV reservoir;Leadership;Life;literacy;Measures;Mediating;meetings;memory CD4 T lymphocyte;Mission;Modeling;Monitor;multidisciplinary;Myeloid Cells;neutralizing antibody;novel;novel strategies;novel therapeutics;Oregon;Passive Immunization;pediatric human immunodeficiency virus;perinatal HIV;Perinatal Infection;Plasma;Population;pre-clinical;Pre-Clinical Model;preclinical efficacy;preclinical safety;preclinical study;Predisposition;Prevention;Primates;programs;purge;Research;Research Personnel;Resources;response;Rest;Role;Safety;Sampling;Science;Shock;side effect;social stigma;Structure;synergism;T cell response;T-Lymphocyte;technology platform;Testing;Therapeutic;therapy duration;Time;Vertical Disease Transmission;Viral;viral rebound;Viral reservoir;Virus;Vision;Work;young adult;Youth

PROJECT_TITLE: Pediatric Adolescent Virus Elimination (PAVE) Martin Delaney Collaboratory


ADMINISTERING_IC: AA

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences;Social Determinants of Health;Substance Misuse

ORG_CITY: BLACKSBURG

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE Human social interactions are important to maintaining our physical and mental health. However, some people experience undesirable outcomes (e.g., alcoholism, depression, addiction) despite having many social ties, and other people report high life satisfaction despite being socially isolated. Here, we use a computational and statistical model-based approach to test how brain sensitivity during social interactions, a measure of how important an interaction is to an individual person, may protect from negative outcomes of social isolation or confer vulnerability despite social connectedness.

PI_NAMEs: CHIU, PEARL H (contact)

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: addiction;Address;Alcohol consumption;Alcoholism;Alcohols;Anxiety;Behavioral;behavioral economics;behavioral response;biopsychosocial;Brain;Characteristics;Computer Models;Consumption;COVID-19;design;Enrollment;Equation;experience;Human;indexing;Individual;interest;Life;Link;Longitudinal cohort;Measures;Mechanics;Mediating;Mediation;Mental Depression;Mental Health;Modeling;Moods;National Institute of Mental Health;National Institute on Alcohol Abuse and Alcoholism;neural;neurobiological mechanism;neuroimaging;Outcome;Participant;Persons;physical conditioning;Play;preference;Procedures;Process;recruit;Reporting;Request for Applications;response;Role;Sampling;satisfaction;Signal Transduction;social;Social Distance;social factors;Social Functioning;social influence;Social Interaction;Social isolation;Social outcome;social structure;Source;Specific qualifier value;Statistical Models;Testing;Time;tool;Trust;Visit;Work

PROJECT_TITLE: Making connections among social ties, neural sensitivity to social signals, and outcomes


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative The project will be relevant to public health because it will establish technologies for elucidating the roles of environmental and endogenous reactive electrophile species in homeostasis and disease and for discovering new drugs. The project aligns with NIH’s mission to enhance health and reduce illness and disability.

PI_NAMEs: FRANZINI, RAPHAEL M. (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: 4 hydroxynonenal;adduct;Atherosclerosis;Biology;chemical reaction;Development;Diet;disability;Disease;disorder prevention;DNA;Environment;Etiology;Foundations;Generations;Goals;Hand;Health;Homeostasis;Human;Inflammation;inhibitor;innovation;Libraries;Link;Location;Malignant neoplasm of pancreas;Malignant Neoplasms;Metabolism;Methodology;Methods;Mission;Nerve Degeneration;novel therapeutics;Organism;Oxidative Stress;Pathologic;Pharmaceutical Preparations;Positioning Attribute;programs;Proteins;Public Health;Research;Resistance;Role;Scientist;screening;Solid;Stress;Technology;Testing;tool;United States National Institutes of Health

PROJECT_TITLE: Tools to Study Electrophilic Stress and Develop Covalent Drugs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Narrative All DNA-templated processes including transcription, DNA replication, and recombination and repair must occur in the context of the local chromatin environment. Failure to properly establish and regulate these DNA-templated processes may lead to genomic and epigenetic instability and potentially tumorigenesis.

PI_NAMEs: MACALPINE, DAVID M (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Cells;Chromatin;Data;Defect;Deposition;DNA;DNA biosynthesis;DNA polymerase A;DNA Polymerase I;DNA replication fork;Environment;Epigenetic Process;Failure;Gene Expression;gene regulatory network;Genetic Recombination;Genetic Transcription;Genome;genome integrity;Genomics;helicase;Histones;insight;Maps;Mediating;Molecular;Molecular Chaperones;mutant;Nucleosomes;Nucleotides;Polymerase;prevent;Process;repaired;Research;Resolution;restoration;Role;S phase;Saccharomyces cerevisiae;Signal Transduction;spatiotemporal;transcription factor;Travel;tumorigenesis;Yeasts

PROJECT_TITLE: Chromatin-mediated mechanisms of genome integrity

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative The STAT4Onc Annual Symposium is a platform where oncology and statistics meet, communicate, and synergize to accelerate cancer treatment development through innovations in statistical and data science and their translations to oncology research.

PI_NAMEs: LU, YING  (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Academia;Acceleration;Address;Adopted;anti-cancer research;Area;Attention;biomarker driven;Biotechnology;Cancer Biology;cancer clinical trial;Cancer Patient;cancer therapy;Cause of Death;Cell Therapy;Characteristics;Clinical Research;clinically actionable;Collaborations;Communication;Complex;cost;Data Analytics;Data Science;Decision Making;Dedications;design;Development;Discipline;disease diagnosis;Drops;drug development;Early Diagnosis;effective therapy;Ethnic Origin;Event;Faculty;Funding;Gender;Genomics;Government;Government Agencies;Immune;improved;individualized medicine;Industry;Inferior;innovation;interdisciplinary collaboration;Interdisciplinary Education;Journals;Language;Malignant Neoplasms;Mathematics;Methodology;Methods;Minority Groups;Modality;Molecular;Molecular Abnormality;mortality;New England;Nonprofit Organizations;novel;novel diagnostics;novel therapeutic intervention;novel therapeutics;Oncologist;Oncology;oncology trial;Participant;Patient Care;Patient Selection;patient subsets;Patients;Pharmacotherapy;posters;precision oncology;predictive marker;Prevention;Professional Organizations;Prognostic Marker;programs;Publishing;Research;research and development;Research Personnel;research to practice;Rotation;Science;Scientist;Statistical Methods;statistics;stem;Students;success;symposium;synergism;targeted agent;Technology;Testing;Therapeutic;therapy development;Time;Training;Translating;Translations;tumor;Underrepresented Minority;Universities

PROJECT_TITLE: Stat4Onc Annual Symposium


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Heterotopic ossification is the process of abnormal bone formation in soft tissues and is caused by genetic mutations and musculoskeletal trauma, both of which involve inflammation. Commensal microbiota can regulate inflammation in mouse and human hosts. This proposal will determine whether commensal microbiota contribute to HO and potentially define a new mechanism by which to control heterotopic ossification.

PI_NAMEs: HSIAO, EDWARD C;PERRIEN, DANIEL S (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Ablation;activin A;ACVR1 gene;Affect;Anti-Inflammatory Agents;Antibiotics;Antigens;Bacteria;Biological Assay;Blood;Bone Marrow;bone morphogenetic protein receptors;cell motility;Cells;Cessation of life;chemokine;Chemotaxis;Chemotaxis Induction;chronic pain;Circulation;Clinical;cohort;commensal microbes;cytokine;Data;Diet;Dietary Factors;Dietary Supplementation;Disease;Disease Outcome;Disease Progression;DNA Sequence Alteration;Environmental Risk Factor;fecal microbiome;fecal transplantation;Flare;Genetic;Genetic Diseases;Germ-Free;Gnotobiotic;Goals;gut microbiome;gut microbiota;Heterotopic Ossification;Home;Human;human induced pluripotent stem cells;Human Microbiome;Immobilization;Immune;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Injections;Innate Immune System;Intramuscular;Joints;Knowledge;Life;Macrophage;Macrophage Activation;Measures;Methods;microbial;microbial community;microbiome;microbiota;Microfluidics;migration;monocyte;mouse model;Mus;Muscle;muscle repair;Musculoskeletal Diseases;musculoskeletal injury;Mutation;Myelogenous;non-genetic;novel;novel therapeutic intervention;Orthopedic Surgery;Osteogenesis;Pain;Patients;Phase;Phenotype;Point Mutation;premature;prevent;probiotic supplementation;Process;Production;progressive myositis ossificans;receptor;response;Role;Severities;Siblings;Signal Transduction;Skeletal Muscle;soft tissue;stool sample;Symptoms;System;systemic inflammatory response;Testing;Transplantation

PROJECT_TITLE: the Gut Microbiome as a Disease Modifier of Heterotopic Ossification

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: Arlington

ORG_NAME: MEDICAL DEVICE INNOVATION CONSORTIUM

PHR: PROJECT NARRATIVE  The mission of the National Evaluation System for health Technology Coordinating Center (NESTcc) is to catalyze the timely, reliable, and cost-effective development of real-world evidence (RWE) to enhance regulatory, clinical, and coverage decision-making throughout the total product lifecycle (TPLC) of a medical device. NESTcc enables research using real-world data (RWD), serves as a Collaborative Community for ecosystem-wide initiatives, and develops capabilities in Active Surveillance for medical device safety. NESTcc provides the infrastructure and expertise to lead the development of RWE research and surveillance activities.

PI_NAMEs: SMITH, RICHARD  (contact)

PROGRAM_OFFICER_NAME: MARION, JILL

PROJECT_TITLE: NESTcc Renewal -Continuation of the National Evaluation System for Health Technology (NEST) Coordinating Center (CC)


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cannabidiol Research;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Mental Health;Neurosciences;Substance Misuse

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE This proposal employs novel methods to identify key determinants and consequences of concurrent HIV infection and regular cannabis use. We will acquire extensive phenotype data from peripheral and brain markers of immune activation, brain structure, and neuropsychological performance in persons living with HIV (PLWH) receiving combination anti-retroviral therapy (cART) (80 regular cannabis users and 80 non- users) and HIV uninfected (HIV-) controls (80 regular cannabis users and 80 non-users). We hypothesize that cannabis use leads to increases in inflammation in the peripheral and brain compartments. We also hypothesize that phenotypic signatures due to regular cannabis use and HIV will be delineated through neuropsychological performance and neuroimaging measures.

PI_NAMEs: ANCES, BEAU M (contact);BURDO, TRICIA HELEN

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Affect;antiretroviral therapy;Brain;Cannabidiol;Cannabis;CCL2 gene;CD14 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;Cellularity;Classification;Cognition;cognitive performance;Complex;Corticospinal Tracts;Counseling;Cross-Sectional Studies;Data;data-driven model;Employment;Encephalitis;executive function;Exhibits;Exposure to;General Population;Health;high dimensionality;Hippocampus;HIV;HIV Infections;Immune;immune activation;immune function;immune health;Immunologic Markers;Impaired cognition;improved;indexing;Inflammation;insight;Learning;Legal;Life;Macrophage;marijuana use;marijuana user;Measurement;Measures;Medical Marijuana;Medicine;Memory;Methodology;Methods;Modeling;monocyte;Neopterin;neuroimaging;Neuropsychology;novel;Outcome;Parietal Lobe;Perforant Pathway;Performance;Peripheral;Persons;Pharmaceutical Preparations;Phenotype;phenotypic data;Plasma;Prevalence;Prevention Guidelines;programs;Psyche structure;Qualifying;Recreational Drugs;Reporting;Research Design;Sampling;Science;Short-Term Memory;Structure;substance use;Survival Rate;System;Temporal Lobe;Testing;Tetrahydrocannabinol;THC concentration;treatment guidelines;Urine;Viral

PROJECT_TITLE: Cannabis, HIV and Mental Processing Systems (CHAMPS)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Prevention;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: PROJECT NARRATIVE  Some arthropod-borne obligate intracellular Rickettsia species are among the most virulent human pathogens. Research in the field of Rickettsia-host interaction is stymied by their obligate intracellular life style, and negatively impacted the progress towards development of effective vaccine against these increasingly recognized rickettsioses. Our overall objective is to determine the mechanism by which secreted effectors from virulent Rickettsia species manipulate macrophage polarization and induce autophagy to subvert inflammasome-dependent proinflammatory cytokine signaling to establish host colonization and identify a link that could be exploited for anti-virulence strategy.

PI_NAMEs: RAHMAN, MOHAMMED SAYEEDUR (contact)

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: Address;Africa;Anti-Inflammatory Agents;Antibodies;Arizona;arthropod-borne;Arthropods;Autophagocytosis;Autophagosome;Bacteria;Bite;Blood;Bone Marrow;Boutonneuse Fever;California;Cd68;Cells;Central America;Complex;cytokine;Cytokine Signaling;Cytosol;Data;Development;Disease Outbreaks;Distant;draining lymph node;effective intervention;Endemic Flea-Borne Typhus;Endothelial Cells;Environment;Epidemic;Etiology;Europe;flea-borne;Goals;Growth;host colonization;Host Defense;Human;human pathogen;Immune;Infection;Inflammasome;Inflammatory;Inflammatory Response Pathway;inhibition of autophagy;Interleukin-1;Interleukin-1 alpha;Interleukin-1 beta;Interleukin-10;Invaded;Knowledge;Life Cycle Stages;Life Style;Link;Macrophage;member;microbial;microbicide;Middle East;monocyte;Organ;pathogen;pathogenic bacteria;Pathogenicity;Pathway interactions;PIK3CG gene;Play;prevent;programs;Proteins;Publishing;recruit;Reporting;Research;response;Rickettsia;Rickettsia conorii;Rickettsia Infections;Rickettsia prowazekii;Rickettsia rickettsii;Rickettsia typhi;Risk;Rocky Mountain Spotted Fever;Role;Signal Transduction;Site;Skin;South America;Spleen;spotted fever;Stream;Structure;Systemic disease;Testing;Texas;therapeutically effective;tick-borne;Time;Tissues;TNF gene;trafficking;Transforming Growth Factor beta;Typhus;Ubiquitination;United States;Up-Regulation;Vaccines;Virulence;Virulent;Wild Type Mouse

PROJECT_TITLE: Rickettsia-host interface and multiple paths to invasion

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


NIH_SPENDING_CATS: Cancer;Climate-Related Exposures and Conditions;Genetics;Human Genome;Prevention;Skin Cancer

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative Field cancerization is a condition of major clinical significance in photo-damaged skin of aging individuals and immune suppressed patients, consisting of multi-focal and recurrent tumor lesions with widespread alterations of surrounding tissues. Our main working hypothesis is that the ULK3 nuclear kinase plays a key role in the field cancerization process and can be targeted for prevention and management of the disease.

PI_NAMEs: DOTTO, GIAN-PAOLO  (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Acetylation;Affect;Alleles;Arginine;Binding;Biochemical;Biological Assay;carcinogenesis;Cell Differentiation process;cell type;Cells;Cervical Squamous Cell Carcinoma;ChIP-seq;Chromatin;Chronic;Clinical;clinically significant;Clustered Regularly Interspaced Short Palindromic Repeats;Co-Immunoprecipitations;Coculture Techniques;Cultured Cells;Dermal;Development;Differentiation and Growth;Disease Management;DNA-Protein Interaction;Ensure;Enzymes;Epidermis;Epigenetic Process;Erinaceidae;Fibroblasts;Future;Gene Deletion;Gene Expression;Gene set enrichment analysis;Gene Silencing;Genes;Genetic;genetic signature;Genetic Transcription;GLI gene;GLI2 gene;Head and Neck Squamous Cell Carcinoma;Head and neck structure;Histone H3;Histones;Homeostasis;Human;Immune;In Vitro;in vivo;Individual;inhibitor;interest;keratinocyte;Lesion;Ligation;Link;Lung;Malignant Epithelial Cell;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Metabolism;Methylation;methylome;Modeling;Morbidity - disease rate;Mus;Nuclear;Oncogenic;organ transplant recipient;overexpression;Patients;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Phosphotransferases;Play;prevent;Prevention;Process;proliferation potential;Promoter Regions;protein kinase inhibitor;Protein-Arginine N-Methyltransferase;Proteins;Recurrent tumor;Regulation;Repression;response;Role;self-renewal;Signal Pathway;Signal Transduction;Site;Skin;Skin Aging;Skin Cancer;skin cancer prevention;skin photodamage;skin squamous cell carcinoma;Squamous cell carcinoma;Stromal Cells;Testing;Tissues;Toxic effect;transcription regulatory network;Transcriptional Regulation;Transgenes;Transgenic Mice;tumor progression;tumorigenic;Ultraviolet B Radiation;UVB induced;Work

PROJECT_TITLE: Epigenetic control of skin homeostasis by the ULK3 nuclear kinase

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Digestive Diseases;Digestive Diseases - (Gallbladder);Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases;Liver Disease;Rare Diseases

ORG_CITY: NAIROBI CITY

ORG_COUNTRY: KENYA

ORG_FIPS: KE

ORG_NAME: KENYA MEDICAL RESEARCH INSTITUTE (KEMRI)

PHR: Salmonella Typhi causes typhoid fever in humans. 1-5% of those with typhoid fever become asymptomatic chronic carriers primarily due to biofilm formation on gallstones. In this proposal, we will study the epidemiology of disease, genetic and phenotypic traits of the strains, and the association of the infection with gallstones of patients in Kenya where typhoid fever is prevalent. The findings will help better understand the transmission of typhoid fever and the development of chronic carriers.

PI_NAMEs: GUNN, JOHN S;KARIUKI, SAMUEL M (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Acute;acute infection;Africa;Animals;Antibiotic Resistance;Antibiotic susceptibility;Antibiotics;Antimicrobial Resistance;Area;Bacteria;Bile fluid;Blood;Cessation of life;Cholelithiasis;Cholesterol;Chronic;chronic infection;Clinical;Communicable Diseases;Communities;data modeling;Development;Diarrhea;Disease;disease transmission;Enteral;Enterobacteriaceae;Environmental Epidemiology;Environmental Risk Factor;Epidemiologic Factors;Epidemiology;epidemiology study;experimental study;Feces;Fever;Gallbladder;Gastroenteritis;Genetic;genome sequencing;Genomics;Genotype;Geography;Goals;Health care facility;Healthcare;Human;human study;Image;Individual;Infection;innovation;insight;Integration Host Factors;interest;Kenya;Life;Link;Maintenance;Maps;Mediating;Microbial Biofilms;Molecular;Molecular Epidemiology;Monitor;Morbidity - disease rate;mortality;mouse model;Multi-Drug Resistance;Outcome;pathogen;Patients;Persons;Phenotype;Population;population based;Prospective Studies;Research;residence;Retrospective Studies;Role;Salmonella;Salmonella typhi;Sampling;Severity of illness;Site;Slum;Systemic disease;Techniques;Testing;trait;transmission process;Typhoid Fever;Urban Community;Variant;Water;whole genome;Work

PROJECT_TITLE: Epidemiology and Genomics of Multidrug resistant Salmonella Typhi infections in  Kenya: The role of carriage in an endemic setting

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-D(55)]


ORG_CITY: IOWA CITY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: NARRATIVE Several diseases are associated with changes in the response of cells to force and altered cell metabolism, but little is known about how these two processes are coordinated. The work in this proposal will provide an understanding for how the response to force is linked to cell metabolism. This information will provide insight into the origin of numerous diseases, ranging from muscular dystrophies and cardiomyopathies to cancer.

PI_NAMEs: DEMALI, KRIS A (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: 5'-AMP-activated protein kinase;Actins;Biochemical;Biological;Biophysics;Cadherins;Cardiomyopathies;Cell Surface Receptors;Cell-Cell Adhesion;Cells;Cellular Metabolic Process;cost;Cytoskeleton;Defect;Disease;E-Cadherin;Epithelium;Glucose;Homeostasis;insight;Link;Malignant Neoplasms;mechanical force;Mechanics;mechanotransduction;Metabolic;Metabolism;Molecular;Muscular Dystrophies;Nature;Organism;Pathway interactions;prevent;Process;Psychological reinforcement;response;Signal Pathway;Signal Transduction;System;Work

PROJECT_TITLE: Molecular Mechanisms Underlying E-cadherin Mechanotransduction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases;Zika Virus

ORG_CITY: LA JOLLA

ORG_NAME: LA JOLLA INSTITUTE FOR IMMUNOLOGY

PHR: NARRATIVE DENV and ZIKV are significant causes of morbidity and mortality worldwide, as half of the world’s population is at risk of DENV and ZIKV infection. DENV and ZIKV vaccines are a global public health priority. To avoid the risk of immune-mediated enhancement of disease, DENV and ZIKV vaccines should induce long-lasting, protective immunity to all four DENV serotypes and ZIKV. This project evaluates a combinatorial DENV-ZIKV vaccine that is designed to induce both humoral and cellular immunity and to provide long-lived protection against infection with DENV1-4 and ZIKV.

PI_NAMEs: SHRESTA, SUJAN  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Address;Adoptive Transfer;Adult;Alpha Virus;Antibody Formation;Antibody Response;Antibody-Dependent Enhancement;Antigens;Avidity;Binding;C57BL/6 Mouse;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cellular Immunity;Child;Clinical Trials;combinatorial;Combined Vaccines;congenital zika syndrome;cross immunity;cross reactivity;Data;Dengue;Dengue Infection;Dengue Vaccine;Dengue Virus;Dengvaxia;design;Development;Disease;Disease Outbreaks;Dose;effector T cell;Epidemic;Epitopes;Flavivirus;Frequencies;Goals;Guillain Barré Syndrome;Healthcare Systems;Human;Humoral Immunities;Immune;Immune response;Immunity;Immunization;Immunize;immunogenicity;improved;Infant;Infection;Licensing;Measures;Mediating;Membrane;Morbidity - disease rate;mortality;Mus;neonate;neutralizing antibody;Nonstructural Protein;Pathogenesis;Persons;Phenotype;Population;prevent;Proteins;public health priorities;Replicon;replicon vaccine;response;Risk;RNA;RNA vaccine;Safety;Serotyping;severe dengue;Severity of illness;T cell response;T-Cell Depletion;T-Lymphocyte;Testing;type I interferon receptor;Vaccinated;Vaccination;vaccine development;vaccine response;vaccine strategy;Vaccines;Virus;Wild Type Mouse;Work;ZIKA;Zika Virus;Zika virus vaccine;ZIKV infection

PROJECT_TITLE: Development of a Replicon RNA-based Vaccine against Dengue and Zika

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Orphan Drug;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Our application is to examine how the super-enhancers (SEs) that control gene expression is assembled in head and neck cancer cells and whether targeting SE inhibits cancer stemness and invasion of head and neck cancer. The discoveries from this study will have important implications in developing novel therapeutic strategies for treating human neck and neck cancer

PI_NAMEs: WANG, CUN-YU  (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Acetylation;Amino Acid Motifs;Binding;Biological Assay;BMI1 gene;Bromodomain;Bromodomains and extra-terminal domain inhibitor;cancer cell;cancer stem cell;cancer therapy;Cell Separation;Cells;Cervical lymph node group;Chemoresistance;ChIP-seq;cofactor;Colorectal Cancer;Combination Drug Therapy;Common Neoplasm;Complex;Cyclin-Dependent Kinases;Development;effective therapy;Enhancers;Epigenetic Process;Exhibits;Family member;Gene Expression;Genes;genetic approach;Genetic Transcription;Genomic Segment;Genomics;Growth;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Head and neck structure;Histone Acetylation;Histone H3;Histone H4;Human;Impairment;improved;in vivo;Individual;inhibitor;Invaded;Lysine;Malignant Breast Neoplasm;Malignant Neoplasms;Mediator;Metastatic Neoplasm to Lymph Nodes;Michigan;Molecular;mouse model;Mutation;Neck;Neck Cancer;Neoplasm Metastasis;Neurofibrillary Tangles;Nitroquinolines;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Oncogenes;Oncogenic;Oral cavity;Oropharyngeal;Oxides;patient derived xenograft model;Patients;Play;prevent;Prognosis;protein degradation;Protein Family;Proteins;Reader;recruit;Relapse;Resistance;Resistance development;RNA Polymerase II;Role;self-renewal;stemness;Subgroup;Survival Rate;Testing;therapeutic target;Tissues;Transcript;Transcription Coactivator;Transcription Elongation;transcription factor;Transcription Initiation;Transcriptional Activation;Transcriptional Regulation;transcriptome sequencing;treatment strategy;tumor;Tumor Cell Invasion;tumor growth;Tumor Promotion;tumorigenic;Universities

PROJECT_TITLE: Targeting Super-Enhancers Suppresses Cancer Stemness and Invasion of HNSCC

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Lung;Pediatric;Sleep Research

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE There is a shortage of well-trained research-oriented physicians who are prepared to develop new approaches to prevent, diagnose and treat childhood respiratory diseases. This proposal will provide a 10 week summer research fellowship for 12 students following their first year of medical school. The strengths of our research programs in the areas of pulmonary and sleep medicine combined with an enthusiastic faculty and a well-organized summer program provides an excellent opportunity to attract physician trainees at early and critical stages in their careers and increase the likelihood they will want to further pursue research as physician-scientists.

PI_NAMEs: AMIN, RAOUF S.;HARDIE, WILLIAM DAVID (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Area;Award;Basic Science;career;Certification;Child;Childhood;Clinical;Clinical Research;Clinical Sciences;Diagnosis;Discipline;Doctor of Philosophy;education research;Faculty;Fellowship;Fellowship Program;Funding;Instruction;interest;Lung;Manuscripts;Medical center;medical schools;Medical Students;Medicine;meetings;Mentors;Methods;National Heart, Lung, and Blood Institute;novel strategies;Pediatric Hospitals;peer;Physicians;Positioning Attribute;prevent;programs;Publishing;Qualifying;Reporting;Research;Research Personnel;Research Project Grants;Research Training;Respiration Disorders;respiratory;Respiratory Disease;responsible research conduct;Scientist;Sleep;Sleep Disorders;Students;success;summer program;summer research;symposium;Training;United States

PROJECT_TITLE: Cincinnati Children's Summer Medical Student Respiratory Research Fellowship


ADMINISTERING_IC: HD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Physical Rehabilitation;Rehabilitation

ORG_CITY: Newark

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE This very successful and innovative training program fuses two independent training programs, a professional Doctorate in Physical Therapy (DPT) and the PhD in Biomechanics and Movement Sciences. The goal of this training program is to train students with the greatest potential to become outstanding research scientists in the field of physical rehabilitation. The program attracts outstanding students and has trained some of our countries most promising rehabilitation clinician scientists.

PI_NAMEs: REISMAN, DARCY S. (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Physical therapy;pre-doctoral;rehabilitation research;Therapeutic Studies;Training

PROJECT_TITLE: Predoctoral Training in Physical Therapy and Rehabilitation Research


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

PHR: Epithelial cancers, including squamous cell carcinoma (SCC) of the skin, represent approximately 95% of malignancies plaguing our Veterans and the U.S. population as a whole. SCC itself arises from sunlight- induced mutations and disproportionately affects the U.S. Veteran population due to the intense sun exposure incurred in military service around the world, including from service efforts in Southeast Asia and the Middle East. To invade tissue and exert destructive effects on health, intrinsically abnormal cells in cancers like SCC must interact with surrounding cells and proteins. The current proposal uses human tissue models of invasive cancer to study both cell intrinsic abnormalities in cancer cells, as well as how such abnormal cells interact with surrounding tissue, with an eye to provide insight for future development of new strategies for cancer prevention and treatment.

PI_NAMEs: KHAVARI, PAUL  (contact)

PROJECT_TERMS: Ablation;Abnormal Cell;Acceleration;Address;Affect;cancer cell;cancer invasiveness;cancer prevention;cancer therapy;Carcinoma;Cell Communication;cell community;Cell secretion;cell stroma;Cell surface;Cell Surface Proteins;cell type;Cells;Cessation of life;COL7A1;Collagen;Collagen Gene;Collagen Type XI;Communication;Complex;Data;Development;Dominant-Negative Mutation;early onset;Environment;Epidermis;Epidermolysis Bullosa;Epithelium;extracellular;Extracellular Matrix;Extracellular Matrix Proteins;Eye;Frequencies;Funding;Future;Gene Expression;Gene Family;Genes;Glycine;Health;Human;human tissue;Impairment;in vivo;Induced Mutation;Inherited;insight;interest;Invaded;keratinocyte;Keratinocyte tumor;Knock-in;Link;Malignant Epithelial Cell;Malignant Neoplasms;Mediating;Messenger RNA;Methods;Middle East;military service;military veteran;Modeling;Morbidity - disease rate;mosaic;mutant;Mutate;Mutation;Neoplasm Metastasis;Neoplasms;neoplastic;neoplastic cell;Normal tissue morphology;Oncogenic;Patients;Population;Proline;Protein Secretion;Proteins;Proteomics;Recurrence;RNA;Role;Series;Services;Set protein;single-cell RNA sequencing;Site;Skin;skin squamous cell carcinoma;Southeastern Asia;Squamous cell carcinoma;Stromal Cells;Sun Exposure;Sunlight;sunlight-induced;Testing;therapeutic target;Tissue Model;Tissues;triple helix;tumor;tumor ablation;tumor progression;Tumor Tissue;tumorigenesis;UV Mutagenesis;UV Radiation Exposure;Veterans

PROJECT_TITLE: REGULATORS OF EPITHELIAL TUMOR PROGRESSION


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Hematology;Pediatric;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: NARRATIVE This study will randomize 234 children and young adults to compare initial treatment with immune suppression therapy (IST) versus well-matched unrelated donor (URD) bone marrow transplantation (BMT). The study will allow us to definitively demonstrate which approach leads to the best outcomes, along with adding invaluable knowledge about quality of life, fertility risks, and important biology questions.

PI_NAMEs: SHAW, BRONWEN  (contact)

PROGRAM_OFFICER_NAME: HAILU, BENYAM

PROJECT_TERMS: Address;Adherence;Age;American;Aplastic Anemia;Area;arm;autoimmune pathogenesis;Biological Factors;Biology;Biometry;Blood;Bone marrow failure;Bone Marrow Transplantation;Boston;Canada;Cell Therapy;Child;Child Care;Childhood;Clinical;clinical application;clinical investigation;clinical research site;clinical trial enrollment;Clinical Trials;Clinical Trials Network;Collaborations;Communication;Cyclosporine;Data;Data Collection;Data Coordinating Center;Dedications;design;Development;Disease;electronic data;electronic patient reported outcomes;Enrollment;Ensure;Equipoise;experience;Fertility;Funding;Goals;Hematology;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Human Resources;Immune;Immunosuppression;improved;Incidence;Infrastructure;international center;Knowledge;Lead;Leadership;Marrow;medical schools;Medidata;member;Monitor;National Heart, Lung, and Blood Institute;Newly Diagnosed;North America;novel therapeutic intervention;Outcome;Participant;Patients;Pediatric Hospitals;Phase;Pilot Projects;pilot trial;programs;prospective;Quality of life;Randomized;randomized trial;Randomized, Controlled Trials;recruit;Reporting;Research;Research Personnel;research study;Resources;response;Risk;Role;Running;safety and feasibility;Seasons;Siblings;Survival Rate;System;Transplantation;transplantation therapy;trial comparing;Wisconsin;young adult

PROJECT_TITLE: 1/2A Phase III Randomized Trial Comparing Unrelated Donor Bone Marrow Transplantation with Immune Suppressive Therapy for Newly Diagnosed Pediatric and Young Adult Patients with Severe Aplastic Anemia


ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Relevance to Public Health Due to its significant involvement in biological processes, chemotaxis contributes to disease progression in cancer and arthritis, while its impairment leads to anomalous tissue development or regeneration. Our unique molecular actuators that can exert “physical force” specifically onto intended intracellular objects, can be a tool for not only dissecting the molecular mechanisms of chemotaxis, but also interfering with these cell migration-related diseases.

PI_NAMEs: INOUE, TAKANARI  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Actins;angiogenesis;Arthritis;Back;Biochemical Reaction;Biological Process;Cell membrane;cell motility;Characteristics;Chemotactic Factors;Chemotaxis;Cytoskeleton;Development;Disease;Disease Progression;Embryonic Development;Event;Exhibits;Feedback;Filopodia;Goals;Impairment;Link;Logic;loss of function;Malignant Neoplasms;Mechanics;Membrane;Molecular;molecular actuator;Monomeric GTP-Binding Proteins;Morphology;Natural regeneration;Neoplasm Metastasis;Nuclear Envelope;operation;Pathologic;Phase;Phenotype;Physical condensation;physical property;Physiological;PIK3CG gene;polarized cell;Property;Proteins;Public Health;Receptor Protein-Tyrosine Kinases;rho GTP-Binding Proteins;Series;Signal Transduction;spatiotemporal;Techniques;Tissues;tool;transcription factor;wound healing

PROJECT_TITLE: Decoding dynamic interplay between signaling and membranes in chemotaxis by molecular actuators

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Behavioral and Social Science;Brain Disorders;Clinical Research;Neurodegenerative;Neurosciences;Rare Diseases;Rehabilitation

ORG_CITY: Charlestown

ORG_NAME: MGH INSTITUTE OF HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that leads to restrictions to daily communication through quantifiable changes in speech acoustics, intelligibility, and speech naturalness. This project seeks to understand the causal linkages between acoustic speech features, perceptual characteristics associated with clinical impressions (listener effort, speech naturalness), and communicative participation in ALS. Understanding these relationships will inform treatment designed to mitigate restrictions by 1) guiding the development and use of evidence-based clinical tools that are associated with communicative participation for assessment and monitoring, and 2) identify specific treatment (e.g., articulatory precision, speech prosody) targets to support communicative participation.

PI_NAMEs: HAENSSLER, ABIGAIL  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Acoustics;Address;Affect;Amyotrophic Lateral Sclerosis;Area;Cellular Phone;Characteristics;Clinical;clinical decision support;clinical decision-making;clinical practice;Communication;Communication impairment;Data;Data Collection;Development;Diagnosis;Disease;Dysarthria;evidence base;experience;falls;Frequencies;Geographic Locations;Goals;Health;Impairment;impression;improved;Individual;innovation;Intervention;Knowledge;Language;Linear Regressions;Link;Measures;Mediating;Mediation;Medical Research;mHealth;Mission;mobile computing;Monitor;motor symptom;National Institute on Deafness and Other Communication Disorders;Neurodegenerative Disorders;optimal treatments;Ownership;Partner Communications;Patient Self-Report;Persons;Prevalence;Production;Quality of life;Research;Signal Transduction;social;Social Network;Speech;Speech Acoustics;Speech Disorders;Testing;therapy design;tool;Voice;Work

PROJECT_TITLE: From Speech Function to Communicative Participation in Dysarthria


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences

ORG_CITY: Boulder

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE  Social relationships, which are intricately tied to our health and well-being, are necessarily reciprocal. The reciprocal interactions that underpin relationships are accompanied by a synchronization of neuronal activity across individuals, referred to as interbrain correlation, which scales as a function of relationship strength. In this proposal, I will measure and manipulate neural activity in monogamous prairie vole pairs to identify the functional contributions of correlated neural activity between animals within the context of pair bonding.

PI_NAMEs: MURPHY, KATHLEEN  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Address;affiliative behavior;Animals;autism spectrum disorder;Automobile Driving;Behavior;Behavioral;Behavioral Paradigm;Calcium;Chiroptera;Complex;Control Groups;Couples;Data;Disease;Exhibits;experience;experimental study;Feedback;Fiber;Fluorescence;fluorophore;Frequencies;Friends;Health;Human;Impairment;Individual;Laboratories;Linear Models;Machine Learning;Mammals;Measures;Medial;Mediating;Mental disorders;Microtus;Modernization;Mus;Nature;neural;neural correlate;Neurons;Neurosciences;Nose;Optics;optogenetics;Pair Bond;Partner in relationship;Pattern;Personal Satisfaction;Persons;Photometry;Posture;prairie vole;preference;Prefrontal Cortex;Proxy;Research Personnel;Risk;Role;sensor;sex;Side;Signal Transduction;skills;social attachment;Social Behavior;social deficits;social engagement;Social Environment;Social Interaction;social relationships;supervised learning;Techniques;Testing;Therapeutic;Time;tool;Touch sensation;Training;unsupervised learning;Work

PROJECT_TITLE: Investigating the role of correlated neural activity in pair bonding using prairie voles


NIH_SPENDING_CATS: Genetics;HIV/AIDS

ORG_DEPT: GENETICS

PHR: PROJECT NARRATIVE P-TEFb phosphorylates the C-terminal domain of the promoter-proximal paused RNA polymerase II as well as other transcription regulatory factors, leading to productive transcription elongation, and it is also an essential host cofactor for HIV-1 transcription. 7SK RNA-protein complexes directly regulate the activity of P-TEFb, sequestering it in an inactive state, but little is known at a structural level about how proteins assemble with 7SK RNA to form a functional RNP and how P-TEFb is hijacked from it by the transactivator of transcription (Tat) protein. Structural studies will provide fundamental molecular insights into and a structural basis for drug targeting of the 7SK RNP that is essential for HIV-1 transcription and therefore escape from latency.

PI_NAMEs: FEIGON, JULI  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: 3-Dimensional;Active Sites;Binding;Binding Proteins;Binding Sites;Biochemical;C-terminal;CDK9 Protein Kinase;Cell Maintenance;circular RNA;cofactor;Complement Factor B;Complex;Cryoelectron Microscopy;cyclin T1;Cyclin-Dependent Kinases;Disease;Drug Targeting;Elongation Factor;Enzymes;experimental study;Genetic Transcription;Goals;Health;Heart Hypertrophy;HIV;HIV-1;Human;In Vitro;in vivo;inorganic phosphate;insight;Laboratories;leukemia;Link;Lymphoma;Messenger RNA;Methods;Methylation;Molecular;Molecular Conformation;NMR Spectroscopy;Phosphorylation;Phosphotransferases;Play;Positive Transcriptional Elongation Factor B;Productivity;promoter;protein complex;Protein Dynamics;Proteins;recruit;Regulation;Reporting;Resistance;RNA;RNA Binding;RNA Conformation;RNA Polymerase II;RNA Recognition Motif;RNA-Protein Interaction;Role;Small Nuclear Ribonucleoproteins;stoichiometry;Stress;structural biology;structural determinants;Structure;Trans-Activators;Transactivation;Transcription Coactivator;Transcription Elongation;transcription factor;Transcription Initiation;Transcriptional Regulation;U6 small nuclear RNA;Untranslated RNA;Viral;Virus Replication;Work;X-Ray Crystallography

PROJECT_TITLE: Structural biology of 7SK RNP and its interaction with HIV-1 Tat

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Congenital Heart Disease;Heart Disease;Heart Disease - Coronary Heart Disease;Pediatric;Pediatric Cardiomyopathy;Physical Activity;Prevention;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Hypertrophic Cardiomyopathy (HCM) is the most common genetic heart disease worldwide with a projected burden of ~2 million affected individuals in the United States and the most common symptom being limitations to physical activity. Approximately ⅓ of these patients have risk for complications with no definitive medical or surgical therapy. Our project will study if exercise training improves exercise tolerance in these patients, and the possible changes in the heart that lead to such improvements, by using sophisticated and modern heart imaging technologies.

PI_NAMEs: ABRAHAM, THEODORE P (contact)

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: Address;Affect;Ammonia;Apoptotic;Attenuated;Belief;Benign;Blood Vessels;Cardiac;Cicatrix;Clinical;Clinical Trials;cohort;common symptom;coping;Coronary;coronary perfusion;Coronary Vessel Anomalies;Data;disability;disabling symptom;Disease;effective therapy;efficacy evaluation;EFRAC;Exercise;exercise capacity;exercise intensity;exercise intervention;exercise intolerance;Exercise Physiology;Exercise Tolerance;exercise training;Experimental Models;Frequencies;Genetic;Goals;Heart;Heart Diseases;Heart failure;heart imaging;heart rhythm;high risk;Home;Hypertrophic Cardiomyopathy;Hypertrophy;Imaging Techniques;Imaging technology;improved;Individual;innovation;Intervention;Intervention Trial;Ischemia;Knowledge;Left;Left Ventricular Outflow Obstruction;Magnetic Resonance;Measurement;Measures;Mechanics;Mediating;Medical;Modernization;Monitor;Multi-Institutional Clinical Trial;Muscle Cells;Myocardial;Myocardial perfusion;Myopathy;Obstruction;Operative Surgical Procedures;Outcome;Oxygen Consumption;Patients;Perfusion;Pharmaceutical Preparations;Physical activity;Positron-Emission Tomography;Process;Productivity;Publishing;Quality of life;Randomized;Randomized, Controlled Trials;Recovery;Rest;Risk;Role;Signal Transduction;standard care;Stress;Stroke Volume;Structure;Symptoms;Testing;Thinking;Time;trend;United States;Vasodilation;Ventricular;Ventricular Arrhythmia;VO2max;Work

PROJECT_TITLE: Exercise Intolerance in Non Obstructive Hypertrophic Cardiomyopathy

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Clinical Research;Lung

ORG_CITY: BALTIMORE

PHR: PROJECT NARRATIVE We have identified a novel association between a polymorphism in a gene involved in the metabolism of fatty acids and increased infection risk in people, thereby implicating an unrecognized role for fatty acid metabolism in human health. This proposal seeks to understand the mechanisms underlying the relationship between fatty acid metabolism and host defense.

PI_NAMEs: NOTO, MICHAEL JAMES (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: aerobic glycolysis;Animal Model;Anti-Bacterial Agents;antimicrobial;Autocrine Communication;Bacterial Pneumonia;Biology;Bone Marrow;Carnitine;Carnitine Palmitoyltransferase I;Cells;Chemotaxis;Clinical;conditional knockout;Coupled;Data;Defect;Dimensions;Disease;Exhibits;fatty acid metabolism;fatty acid oxidation;fatty acid transport;Fatty Acids;Generations;Genes;Genetic Polymorphism;Health;Heterogeneity;Host Defense;Human;Immune;Impairment;Infection;infection risk;Inflammation;inhibitor;Link;long chain fatty acid;Lung;Mediating;Metabolic;migration;Mitochondria;mitochondrial metabolism;Modeling;mortality;mouse model;Mus;Mutation;Natural Immunity;neutrophil;Neutrophil Activation;new therapeutic target;novel;oxidation;Oxidative Phosphorylation;pathogen;Patients;Persons;pharmacologic;phenome;Phenotype;Population;Predisposition;Production;programs;Pulmonary Inflammation;recruit;Regulation;response;Role;Signal Transduction;Site;Testing;trafficking;transcriptomics;Transferase;Work

PROJECT_TITLE: The Role of Mitochondrial Metabolism in Neutrophilic Lung Inflammation

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Caregiving Research;Chronic Pain;Clinical Research;Depression;Dissemination and Implementation Research;Health Services;Mental Health;Pain Research;Palliative Care;Patient Safety

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative . Over 1 million older adults with serious illness have major surgery or severe trauma each year, and palliative care delivered alongside surgical care can help relieve patient suffering, improve post- operative outcomes, and reduce healthcare utilization. Although seriously ill surgical patients benefit from palliative care, they are less likely than other patients to receive it. The proposed study will provide an innovative and layered examination of the role of palliative care in surgery in order to directly inform bedside clinical decisions and the implementation of targeted palliative care interventions to improve care for older seriously ill surgical patients.

PI_NAMEs: COOPER, ZARA R (contact)

PROGRAM_OFFICER_NAME: KELLER, CHANDRA

PROJECT_TERMS: Acute;Address;Administrator;Adult;care delivery;Caregiver Burden;caregiver strain;Caregivers;caregiving;Caring;Certification;Clinical;clinical practice;cohort;Colectomy;Communities;Community Hospitals;contextual factors;Coronary Artery Bypass;daily functioning;Data;Data Sources;Documentation;Elderly;electronic health data;Emergency department visit;end of life care;End stage renal failure;experience;functional decline;Goals;Guidelines;Health;Health and Retirement Study;health care service utilization;health data;health goals;Health system;Healthcare;Healthcare Systems;high risk;hip replacement arthroplasty;hospice environment;hospice utilization;Hospitalization;Hospitals;human old age (65+);Impaired cognition;implementation barriers;improved;improved outcome;informal caregiving;information gathering;innovation;Intervention;Interview;knee replacement arthroplasty;Life;Link;Lower Extremity;Malignant Neoplasms;Manuals;Massachusetts;Measures;Medicare claim;Mental Depression;Methodology;Methods;mortality;Natural Language Processing;novel;Nurses;nursing home length of stay;older adult;older patient;Operative Surgical Procedures;Outcome;Outcomes Research;Pain;Pain Measurement;Palliative Care;patient oriented;Patient-Focused Outcomes;Patients;Perioperative;Physicians;Population;Postoperative Period;pragmatic implementation;Process;Proxy;psychologic;Qualitative Methods;Quality of life;reduce symptoms;Research;Retrospective cohort;revascularization;Risk;Role;severe injury;Site;social;Social Workers;Specialist;surgery outcome;Surgical complication;Surgical Injuries;Testing;Trauma;United States National Institutes of Health;Work

PROJECT_TITLE: A Layered Examination of the Patient Experience to Elucidate the Role of Palliative Care in Surgical Care for Seriously Ill Older Adults

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Serious Mental Illness

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Comorbid posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) is the most common pathological responses to trauma and associated with substantial human disability and a large public health burden. This proposed research is relevant to public health because the results may inform treatments targeting biological factors underlying PTSD and MDD, thereby improving outcomes for this difficult-to-treat population.

PI_NAMEs: ALBOTT, CRISTINA SOPHIA (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Aftercare;Amygdaloid structure;Bilateral;Biological;Biological Factors;biomarker identification;Chronic stress;Clinical;clinical predictors;Clinical Research;Cognition;cognitive function;cohort;comorbidity;Data;Depressed mood;design;Development;disability;Disease;disease model;Executive Dysfunction;experience;Extinction;Functional disorder;Functional impairment;Goals;Grant;Health;health care service utilization;high risk population;Hippocampus;Human;Impaired cognition;Impairment;improved;improved outcome;Individual;Infusion procedures;innovation;Intervention;K-Series Research Career Programs;Ketamine;Knowledge;Learning;Major Depressive Disorder;Measures;Medicine;Memory;Mental Depression;Mentors;Methods;Modeling;neural circuit;Neuroanatomy;neurobiological mechanism;Neurobiology;neuroimaging;Neuronal Plasticity;novel;Participant;Pathologic;Patient Self-Report;Pattern;Performance;Placebos;Population;Post-Traumatic Stress Disorders;Pre-Clinical Model;predicting response;Prefrontal Cortex;Public Health;Randomized;Recovery;rehearsal;Research;Research Personnel;response;rumination;Saline;Series;skills;Statistical Methods;Stress;suicidal risk;Symptoms;synaptic function;System;Training;Training Support;Trauma;trauma exposure;Treatment outcome;Veterans

PROJECT_TITLE: Characterization of Comorbid Posttraumatic Stress Disorder and Major Depressive Disorder Utilizing Ketamine as an Experimental Medicine Probe


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Social Determinants of Health

PHR: Project Narrative The proposed research is clinically relevant as it could lead to improved health care policies, as well as provide a foundation for future dementia care workforce research in skilled nursing facilities. By studying the dementia care workforce and the training they receive to care for residents in skilled nursing facilities, the project supports the Notice of Special Interest (NOT- AG-20-026) to examine the impact of this workforce on care outcomes. By studying two priority populations: (1) racial and ethnic minority workers and (2) the elderly, the project supports research aimed at improving the quality of care and the work environment in skilled nursing facilities.

PI_NAMEs: WAGNER, LAURA M (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Absenteeism;Aggressive behavior;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Amendment;American;Aphasia;Attitude;Behavior;Behavioral Symptoms;burnout;Care given by nurses;care outcomes;Caring;Cause of Death;Certification;Characteristics;Classification;clinically relevant;cohort;Communication;Communication difficulty;Data;Data Element;Data Set;Dementia;dementia care;demographics;Diagnosis;Discipline of Nursing;Drug usage;Educational Curriculum;Elderly;Elements;Ensure;ethnic diversity;ethnic minority;Ethnic Origin;Evaluation;Event;evidence base;experience;Face;Focus Groups;Foundations;Frequencies;Future;Geography;Goals;Health;health disparity;Health Policy;Health Status;improved;individual variation;innovation;interest;Knowledge;Licensed Practical Nurse;Link;Measures;Methods;Modality;Modeling;Nurse Administrator;Nursing Staff;Occupations;older adult;Online Systems;Outcome;Paranoia;Participant;Persons;Physical Restraint;Policies;Population;Population Heterogeneity;Process;professional atmosphere;programs;Provider;Psychotropic Drugs;Qualifying;Quality of Care;Race;racial discrimination;racial diversity;racial minority;recruit;Registries;Regulation;Reporting;Research;research study;Research Support;Safety;Skilled Nursing Facilities;skills;skills training;Societies;Staff Development;Standardization;standardize measure;Strategic Planning;Subgroup;Surveys;symptom management;Symptoms;Testing;therapy development;Training;Training Programs;Violence;virtual;Wages;Workplace;workplace violence

PROJECT_TITLE: Relationships of dementia care workforce experiences, training, & work environment to resident outcomes in skilled nursing facilities

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_DEPT: FAMILY MEDICINE

PHR: PROJECT NARRATIVE Work is central to the lives of American adults, but the relationship between work, unemployment, and ADRD across the lifecourse has been understudied. This proposal evaluates lifecourse employment trajectories (Aim 1) and lifecourse cognitive demands (Aim 3); we will further create a longitudinal database of job demands (Aim 2). We hypothesize that fewer spells of unemployment and more cognitively stimulating employment are protective for cognitive decline and dementia, independent of education and other sociodemographic factors.

PI_NAMEs: VABLE, ANUSHA MURTHY (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Address;Adult;Age;Alzheimer's disease related dementia;American;Behavioral;Calibration;career;Categories;Cause of Death;Censuses;Characteristics;Classification;Code;Cognitive;cohort;Computers;Data;data harmonization;Data Set;Dementia;dementia risk;Diagnosis;Dictionary;Digit structure;Disease;disorder risk;Disparity;Education;Employment;Etiology;experience;Gender;Geography;Goals;Health;Health and Retirement Study;human old age (65+);Impaired cognition;Incidence;Income;Individual;Information Networks;instrument;Intervention;Job loss;late life;Life Cycle Stages;Literature;longitudinal database;manufacture;Maternity leave;Methodology;middle age;Modification;National Longitudinal Survey of Youth;Nature;novel;Occupational;Occupations;panel study of income dynamics;Patient Self-Report;Pattern;Persons;Population;population based;Process;Publishing;Race;Research;Respondent;response;Risk Factors;Scholarship;Sequence Analysis;Services;social;social determinants;Social Environment;Social Network;sociodemographic factors;spelling;Surveys;System;Testing;theories;Time;Unemployment;United States;Work

PROJECT_TITLE: Occupational transitions across the lifecourse and dementia risk: evaluating unemployment, occupational complexity using sequence analysis

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE The health of the elderly in the United States has improved substantially in recent decades, but immense disparities persist across geographies, race, and socio-economic groups. The objective of the proposed research is to examine the relative roles of two broad-based forces affecting elderly health and health behaviors: person-specific factors and place-specific factors. These findings will generate a clearer understanding of the factors that affect the elderly’s health behaviors and health and shed light on the likely efficacy of alternative policies aimed at improving elderly health behaviors and health.

PI_NAMEs: FINKELSTEIN, AMY N. (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Acute;addiction;Affect;Age;age group;Alternative Therapies;Area;Capital;Caring;Characteristics;Climate;combat;Data;design;disabled;Disparity;Economic Models;Economics;Elderly;Endowment;Environment;Funding;Genetic;geographic difference;Geographic Locations;Geography;Goals;Grant;Health;Health behavior;Health behavior and outcomes;health care service utilization;health disparity;Health Insurance;Health Status;Healthcare;improved;improved outcome;Income;Individual;large datasets;Life Expectancy;Location;Longevity;Measures;Medical;Medicare;Mental Health;Methodology;Methods;Modeling;mortality;mortality disparity;Opiate Addiction;Opioid;opioid abuse;opioid epidemic;opioid use;Outcome;Pattern;Persons;Physicians;Policies;Pollution;Population;prescription monitoring program;prescription opioid;programs;Race;racial disparity;racial population;Research;Research Design;Role;Running;socioeconomic disparity;Socioeconomic Factors;Socioeconomic Status;socioeconomics;Substance abuse problem;Time;treatment effect;United States;Work

PROJECT_TITLE: Determinants of Elderly Health: The Role of Place-Based Factors

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Excessive alcohol consumption and binge-drinking behavior is a major health concern in the United States, which manifests differently between males and females but lacks efficient treatments. This project will determine whether Neuropeptide Y1 projection-neurons between the central amygdala and lateral hypothalamus are involved in a mouse model of binge-like ethanol consumption. These results will help establish the basis of sex-specific neurocircuitries involved in binge-drinking behavior, ultimately leading to improved treatment.

PI_NAMEs: BENDRATH, SOPHIE CHARLOTTE (contact)

PROGRAM_OFFICER_NAME: GRAKALIC, IVANA

PROJECT_TERMS: Affect;Agonist;Alcohol consumption;Alcohol dependence;alcohol use disorder;Alcohols;Amygdaloid structure;Animal Model;antagonist;Attenuated;Bilateral;Binding Sites;binge drinking;Blood;Brain region;Cannulas;Cannulations;career;Cells;Clozapine;Consumption;Corticotropin-Releasing Hormone;Coupled;Darkness;Data;Dependence;designer receptors exclusively activated by designer drugs;Development;Diagnosis;Dose;drinking;drinking behavior;Ethanol;Ethanol dependence;Exhibits;experimental study;Female;Financial Hardship;Frequencies;gamma-Aminobutyric Acid;Genetic;Goals;Health;Health Care Costs;Heavy Drinking;Histologic;Hypothalamic structure;Immunohistochemistry;improved;Infusion procedures;Injections;insight;Intake;Lateral;Lead;male;men;Messenger RNA;Methods;Microinjections;mouse model;Mus;National Research Service Awards;neural;neural circuit;neuromechanism;Neurons;neuropeptide Y;neuropeptide Y-Y1 receptor;Neuropeptides;overexpression;Oxides;Pathway interactions;pharmacologic;Pharmacology;Procedures;promoter;Proteins;Public Health;receptor;Receptor Activation;Receptor Cell;receptor density;receptor expression;Receptor Signaling;Regulation;Research;Research Training;Risk Factors;Rodent Model;Role;sex;Sex Differences;Signal Transduction;Site;societal costs;Stress;Sucrose;System;Technical Expertise;Techniques;Technology;Testing;Time;Training;Transgenic Organisms;United States;Viral;Viral Vector;Western Blotting;Woman;women's diagnosis;Work

PROJECT_TITLE: Central Amygdala to Lateral Hypothalamus Neuropeptide Y projections as a Target in Sex-Specific Binge-Like Ethanol Consumption in Mice


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Pediatric;Substance Misuse

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Public Health Relevance  Young adults are disproportionately affected by HIV and have the highest rates of new infections in the U.S. Contrary to intuition, up to one-third of these young adults suffer from HIV-associated neurocognitive impairment (HAND) that impacts daily functioning and long-term brain function. However, the diagnosis of HAND remains difficult due to a lack of biomarkers to measure ongoing inflammation and an incomplete understanding of its causes. Substance abuse, including high rates of marijuana use among young adults, have untold effects on neurocognition and may modulate levels of inflammation. However, the impact of marijuana on inflammation and cognition is understudied despite increasing use and legalization. This study will combine neuroimaging, neurocognitive testing, and advanced immunology to understand HAND immunopathogenesis and identify novel pathways and measures of inflammation. Results will provide much needed data upon which future clinical trials and clinical practice can better diagnose HAND to develop therapies for this common complication of HIV infection in young adults.

PI_NAMEs: MURDOCH, DAVID MARTIN (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Address;Adult;Affect;Affinity;Anti-Inflammatory Agents;antiretroviral therapy;Automobile Driving;axon injury;Benzodiazepine Receptor;Biological Markers;Biology;biomarker validation;Brain;candidate marker;cannabinoid receptor;Cannabinoids;CCL2 gene;Cell Physiology;Cells;Cerebrospinal Fluid;Clinical;clinical practice;Clinical Trials;Cognition;comorbidity;Complication;daily functioning;Data;density;detection assay;Diagnosis;Disease Management;Drug abuse;Drug Modulation;drug of abuse;Drug usage;Future;Genes;glial activation;Goals;HIV;HIV diagnosis;HIV Infections;HIV-associated neurocognitive disorder;HIV-infected adolescents;imaging capabilities;Immune;immune modulating agents;Immune System Diseases;Immunologics;Immunology;immunoregulation;Impaired cognition;Impairment;improved;In Vitro;Infection;Inflammation;Inflammatory;inflammatory marker;Infrastructure;innovation;insight;Institution;Intervention;Intuition;Label;Legal;Ligands;Macrophage;Magnetic Resonance Imaging;Marijuana;marijuana use;marijuana user;Measures;Methods;Microglia;monocyte;Morbidity - disease rate;Myelogenous;Myeloid Cell Activation;Myeloid Cells;Neopterin;neuroAIDS;Neurocognition;Neurocognitive;Neurocognitive Deficit;neurocognitive test;neurofilament;neuroimaging;neuroinflammation;Neurologic;Neuronal Injury;neuroprotection;novel;novel therapeutics;Participant;Pathogenesis;Pathway interactions;Patients;performance tests;Peripheral;Persons;Pharmaceutical Preparations;Positioning Attribute;Positron-Emission Tomography;predictive marker;preservation;Productivity;prospective;public health relevance;radiotracer;Research;Research Infrastructure;Resolution;response;Role;Severities;single molecule;single-cell RNA sequencing;Structure;Substance abuse problem;Synapses;systemic inflammatory response;T-Lymphocyte;Techniques;Technology;Testing;therapy development;tool;Tracer;transcriptome;transcriptomic profiling;transcriptomics;TREM2 gene;Work;young adult;Youth

PROJECT_TITLE: Pathogenesis of Neuroinflammation and Neurocognitive Impairment In HIV-infected Young Adult Cannabis Users


NIH_SPENDING_CATS: Biotechnology;Kidney Disease

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: NARRATIVE Chronic kidney disease (CKD) affects 276 million people worldwide and can ultimately progress to complete renal failure and the need for dialysis or transplantation. A hallmark of CKD is the abnormal leak of serum proteins into the urine (i.e., proteinuria), and high urinary protein excretion carries an overall worse prognosis and greater likelihood of disease progression. This proposal targets a novel mechanism for proteinuric CKD, the β-catenin/MCP-1 pathway, the results of which will lead to a new understanding of CKD and contribute to the development of rational treatments for this disease.

PI_NAMEs: BONDI, CORRY DOMINIC (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Ablation;Adriamycin PFS;Affect;Albumins;Angiotensin II;Automobile Driving;beta catenin;Binding;Biology;CCL2 gene;Cell Culture Techniques;Cells;chromatin immunoprecipitation;Chronic Kidney Failure;cofactor;Collaborations;Data;Development;Dialysis procedure;Disease;Disease Progression;Down-Regulation;Educational workshop;End stage renal failure;Ensure;Enzyme-Linked Immunosorbent Assay;Epithelial Cells;Epithelium;Excretory function;experience;experimental study;Exposure to;Extravasation;Filtration;Foot Process;Fostering;Functional disorder;Funding;Future;Genetic;Glomerular Filtration Rate;glomerulosclerosis;Goals;Health;Health Care Costs;Immunofluorescence Immunologic;In Vitro;in vivo;inhibitor;Injury;Injury to Kidney;Kidney;kidney cortex;Kidney Diseases;Kidney Failure;kidney imaging;Knockout Mice;Laboratories;Mediating;Mentored Research Scientist Development Award;Mentors;Mentorship;Messenger RNA;Modeling;Molecular;monocyte chemoattractant protein 1 receptor;Morbidity - disease rate;Morphology;mortality;mouse model;Mus;neglect;Nephrons;neutralizing antibody;novel;Pathway interactions;Permeability;Persons;Plasma;Play;podocyte;Production;Productivity;Prognosis;promoter;protein expression;Proteins;Proteinuria;Quality of life;Rattus;Receptor Activation;renal damage;Renal function;Renal glomerular disease;Renal tubule structure;Research;Research Personnel;Resources;response;response to injury;Rodent Model;Role;Route;Serum Proteins;slit diaphragm;Small Interfering RNA;Structure;Technology;Testing;Therapeutic Intervention;Time;Training;transcription factor;Transmission Electron Microscopy;Transplantation;Travel;Tubular formation;Universities;urinary;Urine;Western Blotting;Writing

PROJECT_TITLE: The Role of MCP-1 in Tubular-to-Glomerular Crosstalk in Proteinuric Kidney Disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Neurosciences;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO

ORG_STATE: NM

PHR: PROJECT NARRATIVE The proposed longitudinal study examines the maturation of brain and behavioral mechanisms that motivate the exploration of novel choice options in adolescents and young adults with varying degrees of alcohol use problems. We will test the overarching hypothesis that persistent immaturity of exploratory decision making computations predicts greater alcohol use problems in adolescence and young adulthood. This study uses an innovative computational developmental neuroscience approach to chart the growth curves of different novelty- directed behaviors in adolescence and young adulthood, which could aid in the design of preventative interventions for reducing alcohol use disorder risk in adolescence.

PI_NAMEs: HOGEVEEN, JEREMY P (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Acceleration;addiction;Address;Adolescence;Adolescent;adolescent alcohol abuse;Adolescent and Young Adult;Adult;Affective;age related;Alcohol abuse;Alcohol consumption;alcohol monitoring;alcohol research;alcohol risk;alcohol use disorder;Alcohols;Amygdaloid structure;Automobile Driving;Behavior;Behavioral Mechanisms;Biological Assay;Brain;Cellular Phone;Chronic;chronic alcohol ingestion;Clinical;Cognitive;Computer Models;Corpus striatum structure;Cross-Sectional Studies;Curiosities;Data;Decision Making;Decision Trees;design;Development;diaries;Dimensions;disorder risk;Dissociation;drinking;early drinking;Environment;experience;experimental study;Exploratory Behavior;Food;Friends;Functional Magnetic Resonance Imaging;Future;Goals;Growth;Health;improved;in vivo;Individual;innovation;Intervention;Laboratories;Learning;Life;Link;Lobule;Longitudinal Studies;Measurement;Measures;Methods;Modeling;Motivation;neural;neural circuit;neurodevelopment;neuroimaging;neuromechanism;Neurons;Neurosciences;novel;Parents;Participant;peer;Personality;Persons;Phenotype;Positioning Attribute;predictive test;preference;Prefrontal Cortex;preventable death;preventive intervention;programs;Punishment;random forest;Randomized;recruit;reduced alcohol use;Research;Research Personnel;resilience;response;Rewards;Risk;Science;Sensory;Severities;Shapes;skills;social;social influence;societal costs;Stimulus;Testing;tool;trait;underage drinking;Visit;Work;young adult;Youth

PROJECT_TITLE: Neurodevelopment of exploration and alcohol problems in adolescence

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative The antigen presenting molecule MR1 is fundamentally different than any other antigen presenting molecule in the human immune system. It is ubiquitously expressed in tissues, including the lungs, and is poised to rapidly detect intracellular infection. A better understanding of how MR1 presents antigens from Mycobacterium tuberculosis will be critical to the development of future MR1 based therapies against the disease.

PI_NAMEs: KARAMOOZ, ELHAM  (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Adopted;Affect;Antigen Presentation;Antigen-Presenting Cells;Antigens;arm;Award;Basic Science;Binding;Biometry;Calcium;Calcium Channel;calcium indicator;Calcium Signaling;career development;Cell membrane;Cell surface;Cells;clinically relevant;Collaborations;Communicable Diseases;Data;Detection;Development;Development Plans;Disease;Endosomes;Environment;experience;Fluorescence Microscopy;Future;Glycolipids;Goals;Health;Histocompatibility Antigens Class II;Human;Immune system;immune system function;Immunology;Immunotherapy;Infection;innovation;Institution;interest;knock-down;Knowledge;late endosome;Ligands;Lipids;live cell imaging;Lung;Masks;Measurement;Measures;Mentors;Metabolism;Microbe;microbial;Modeling;Molecular;mortality;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;novel;Oregon;pathogen;Peptides;Positioning Attribute;Process;protein transport;rapid detection;Recycling;Research;Resistance;Role;Sampling;Science;Scientist;Signal Transduction;skills;small molecule;symposium;synaptotagmin;syntaxin 16;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;Techniques;Tissues;trafficking;Training;Tuberculosis;Universities;Work;Writing

PROJECT_TITLE: MR1-dependent presentation of Mycobacterium tuberculosis: a unique role for calcium signaling

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Brain Disorders;Cannabinoid Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Natural Products;Neurosciences;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Narrative: 40-72% of people living with HIV use cannabinoids to reduce anxiety, stress, depression, antiretroviral drug side effects and/or for pleasure. There is abundant evidence that cannabinoids have anti-inflammatory and immunomodulatory effects; however, the mechanism that underlie these effects are not understood. We propose to determine the effects of cannabinoids on three cells of the central nervous system in the context of HIV infection and antiretroviral therapy treatment in the hopes of identifying anti-inflammatory mechanisms to reverse neurological dysfunction in people living with HIV.

PI_NAMEs: JORDAN-SCIUTTO, KELLY L (contact)

PROJECT_TERMS: Anti-Inflammatory Agents;Anti-Retroviral Agents;Antiinflammatory Effect;antiretroviral therapy;Anxiety;anxiety reduction;Astrocytes;Attenuated;biological adaptation to stress;Body System;Cannabinoids;Cannabis;Cell Lineage;Cells;Central Nervous System;Central Nervous System Diseases;Chronic;CNR1 gene;Colitis;Colon;comorbidity;Complex;cytokine;Dendritic Cells;Disease;Dissection;Drug Side Effects;Environment;Exhibits;experience;Experimental Autoimmune Encephalomyelitis;fetal;Functional disorder;Gene Expression;Gene Expression Profile;glial activation;Heart;HIV;HIV Infections;Human;human induced pluripotent stem cells;Immunomodulators;immunoregulation;Induced Neurons;Inflammasome;Inflammation;Inflammatory;Kidney;Kinetics;Life Expectancy;Liver;Macrophage;marijuana use;Medicine;Mental Depression;Microglia;Modeling;Morphology;Myelogenous;Myocardial Infarction;Neurologic Dysfunctions;Neuronal Dysfunction;Neurons;Oxidative Stress;Pain;painful neuropathy;Pathway interactions;Patients;Pattern;Persons;phytocannabinoid;pleasure;Production;Property;receptor;Reporting;Role;side effect;Signal Pathway;Signal Transduction;Stress;T-Lymphocyte;Tissues;Viral

PROJECT_TITLE: Inter- and Intra-cellular effects of cannabinoids, HIV and ART in the CNS


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Contraception/Reproduction;Pediatric

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE UNC's Reproductive, Perinatal, and Pediatric Epidemiology Predoctoral Training Program prepares the next generation of epidemiologists to investigate the real world problems in reproductive, perinatal, and pediatric health.

PI_NAMEs: DANIELS, JULIE L (contact)

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: Pediatric epidemiology;Perinatal Epidemiology;reproductive epidemiology;Training Programs

PROJECT_TITLE: Training Program in Reproductive, Perinatal and Pediatric Epidemiology


ORG_CITY: BLOOMINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project narrative Mutations play a fundamental role in both adaptation and disease. This project will investigate the rate at which mutations arise at different stages of germline development. It will do this in a nonhuman primate that is a model for reproductive and developmental biology.

PI_NAMEs: HAHN, MATTHEW WILLIAM (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Affect;Age;Birth;Black Box;Blood specimen;Cells;Data;de novo mutation;deep sequencing;Detection;Development;Developmental Biology;Disease;disease transmission;disease-causing mutation;disorder risk;Embryo;Embryonic Development;Eukaryota;Evolution;experimental study;Family;Fathers;Fertilization;Frequencies;Gametogenesis;Generations;genetic pedigree;Genome;genome sequencing;Germ Lines;Goals;Individual;Macaca mulatta;male;Mammals;Measures;Modeling;Monozygotic twins;mosaic;mosaic variant;Mosaicism;Mothers;Mutation;nonhuman primate;novel;offspring;Paired Comparison;Parents;Placenta;Play;Primates;Process;Puberty;Recurrence;Reproductive Biology;Risk;Role;Shapes;Siblings;Son;Source;sperm cell;Technology;Testing;Time;Tissues;transmission process;Variant;Work

PROJECT_TITLE: Dissecting the mechanisms and timing of de novo mutations in primates

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]