ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: MORGANTOWN

ORG_DEPT: BIOLOGY

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: Project Narrative Understanding how chemical exposure affects organisms provides insight into understanding basic cellular metabolism, as well as paving the way for the treatments of neurological diseases and metabolic disorders. The glyphosate’s (the active ingredient in a popular herbicide) effects on cellular metabolism have hinted at mitochondrial targets but the mechanism is not known yet based on how it’s imported into cells it’s likely affecting enzymes that use glutamate and aspartate. Using S. cerevisiae, brewer’s yeast, as a model, we will determine how pure glyphosate and commercial preparations change mitochondrial function allowing for future studies on affected organs in humans.

PI_NAMEs: GALLAGHER, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Acute;Affect;Amino Acids;Animals;Aromatic Amino Acids;Aspartate;Bacteria;Binding;Binding Proteins;Biochemical;Brain;Bypass;cancer type;Cell Cycle;Cells;Chemical Exposure;Cytoplasm;Data;Data Set;Diet;Disease;DNA Damage;Down-Regulation;Enzymes;Evolution;experimental study;exposed human population;Food Chain;Food Contamination;Formulation;fungus;Future;Genes;Genetic;genome wide association study;Glutamate Transporter;Glutamates;glyphosate;Goals;Growth;gut microbiome;Health;Herbicides;Human;Human Development;innovation;insight;Malate-Aspartate Shuttle Pathway;Malates;Measures;Metabolic Diseases;Metabolism;mimicry;Mitochondria;mitochondrial metabolism;Mitochondrial Proteins;model organism;Modeling;mutant;NADH;Nervous System Disorder;Nutrient;Nutrient availability;Occupational Exposure;Organ;Organism;Pathway interactions;Penetration;permease;Plants;Preparation;Regulation;Repression;Reproduction;Research;Resistance;Role;Saccharomyces cerevisiae;sensor;shikimate;Site;Structure;Supplementation;surfactant;Testing;Time;Tissues;Toxic effect;transcriptomics;Transportation;Urine;Yeasts

PROJECT_TITLE: Amino acid mimicry: Insights into glyphosate transport and toxicity to mitochondria

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


ADMINISTERING_IC: AR

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Lymphatic Research;Lymphedema;Obesity;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE This research and career development award proposal is relevant to public health because it examines strategies to prevent chronic lymphedema, a condition which impacts up to 5 million cancer patients in the United States. I will elucidate mechanisms underlying pathologic fat tissue deposition in lymphedema, and develop strategies to prevent this condition. Through this career development award, I will engage in formal training, workshops, and conferences to further my career as a physician-scientist with the goal of performing translational research.

PI_NAMEs: AGARWAL, SHAILESH  (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Achievement;Address;adipocyte biology;adipocyte differentiation;Adipocytes;Adipose tissue;adverse outcome;Affect;Agonist;antagonist;Apoptosis;Apoptotic;Autologous;Award;Bioinformatics;Biology;Cancer Patient;career;Cell Differentiation process;Cell Survival;Cell Therapy;cell type;Cells;Chronic;chronic pain;Clinical;Data;Deposition;Educational workshop;Engineering;Engraftment;Environment;Evaluation;exosome;expectation;experience;Face;Fatty acid glycerol esters;Functional disorder;Funding;genetic signature;Goals;Hindlimb;Histologic;Impairment;inhibitor;insight;Institution;K-Series Research Career Programs;Knockout Mice;Laboratories;Leadership;Limb structure;Local Therapy;Lymph;Lymphatic;Lymphedema;MAP3K7 gene;Maps;Mechanics;Mediator;Mentors;Mentorship;Mesenchymal;MicroRNAs;Mobility decline;Modification;Monitor;mouse model;Mus;Obesity;oligonucleotide delivery;open wound;Operative Surgical Procedures;Pathogenesis;Pathologic;Pathology;Patients;pharmacologic;Physicians;Plastic Surgical Procedures;Population;Predisposition;prevent;Process;Proliferating;Public Health;Quality of life;receptor;Research;research and development;rosiglitazone;Scientist;secondary lymphedema;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;skills;stem cell biology;stem cell fate;stem cell population;stem cells;subcutaneous;success;Swelling;symposium;Tamoxifen;Technical Expertise;Therapeutic;therapy adverse effect;Time;Tissues;Training;transcriptome sequencing;translational medicine;Translational Research;translational therapeutics;treatment strategy;United States;uptake;Wages

PROJECT_TITLE: Modifying adipocyte and pre-adipocyte cell fate in fibroadipose tissue of secondary lymphedema

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: NARRATIVE Glioblastoma (GBM) is a uniformly fatal disease with very few clinical options and is driven by abnormal signal transduction, originating from oncogenic drivers and loss of tumor suppressors, resulting in heightened glycolytic flux that can be therapeutically targeted for exploitation. We hypothesize a combination of standard of care 18F- FDG PET, which measures glucose uptake, fast pH- and oxygen-sensitive amine chemical exchange saturation transfer spin-and-gradient-echo echoplanar imaging (CEST-SAGE-EPI), a molecular MRI technique that can estimate acidity from lactic acid and oxygen utilization, as well as perfusion and diffusion MRI to account for the effects of blood flow/volume and cell density can be used to create a “glycolytic index”, or GI, that will allow us to accurately quantify glycolytic flux within heterogeneous tumors on widely available clinical imaging systems for use in studying glucose metabolism and response to a variety of targeted therapies in human GBM. The current study will (Aim 1) confirm the association between tumor tissue measures of glycolysis and the “glycolytic index”; and (Aim 2) quantifying changes in the “glycolytic index” and correlation with glycolytic signaling alterations through perturbation of glycolysis using a brain penetrant EGFR inhibitor specifically designed for GBM (i.e. ERAS801).

PI_NAMEs: ELLINGSON, BENJAMIN M. (contact);NATHANSON, DAVID A.

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: Acidity;Amines;Behavior;behavioral response;Bioenergetics;Biological;Biopsy;Biopsy Specimen;Blood flow;Brain;Brain Neoplasms;brain tissue;candidate marker;Cell Density;Cells;Chemicals;Clinical;clinical imaging;Collaborations;Data;design;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Early Diagnosis;Echo-Planar Imaging;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Exhibits;extracellular;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;Gene Expression;Genetic Transcription;Glioblastoma;Glucose;glucose metabolism;glucose uptake;GLUT-3 protein;Glycolysis;hexokinase;Human;Image;Image Guided Biopsy;imaging biomarker;imaging system;Immunohistochemistry;indexing;Inferior;insight;Isocitrate Dehydrogenase;Lactic acid;Magnetic Resonance Imaging;Malignant Neoplasms;Measurement;Measures;Medical;Metabolic;Metabolic Pathway;Molecular;Monitor;Mutate;Mutation;novel;Oncogenes;Oncogenic;Oxidative Phosphorylation;Oxygen;Oxygen Consumption;Pathway interactions;patient derived xenograft model;Patients;Pentosephosphate Pathway;Perfusion;perfusion imaging;pharmacologic;Phase I Clinical Trials;Phosphorylation;Positron-Emission Tomography;Predisposition;Production;prospective;protein expression;Receptor Inhibition;Recurrence;response;Signal Transduction;Signal Transduction Pathway;Specificity;standard of care;targeted treatment;Techniques;theories;Therapeutic;therapeutic target;Tissues;TP53 gene;transcriptome sequencing;treatment response;tumor;Tumor Suppressor Proteins;Tumor Tissue;uptake;Work

PROJECT_TITLE: Quantitative molecular MR-PET imaging of glycolysis in glioblastoma

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Asthma;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Genetics;Health Effects of Indoor Air Pollution;Infectious Diseases;Lung;Pediatric;Prevention;Social Determinants of Health

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Schools represent a source of exposure to respiratory viruses, yet the magnitude of risk that schools represent is unknown. The proposed research is relevant to the part of NIH’s mission to promote healthier environments by describing the molecular epidemiology of circulating respiratory viruses in schools compared to homes, identifying potentially modifiable factors or interventions in the indoor school environment that impact respiratory virus exposure, and identifying the contribution of respiratory virus exposure to asthma morbidity in students. We urgently need research to identify practical and evidence-based strategies to create safe indoor school environments for students.

PI_NAMEs: LAI, PEGGY SUE (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Adenoviruses;Adherence;Affect;Air;air filtration;Asthma;Behavior;built environment;Carbon Dioxide;Child;Childhood;Contact Tracing;Coronavirus;COVID-19;COVID-19 incidence;COVID-19 outbreak;COVID-19 patient;Data;design;Detection;Disease Outbreaks;disease transmission;Disinfectants;Dust;effective intervention;elementary school;Enterovirus;Environment;Environmental Health;environmental intervention;Environmental Risk Factor;evidence base;Exposure to;Fatigue;Future;Genetic;Genome;Goals;Handwashing;high efficiency particulate air filter;high risk;Home;Hospitalization;Household;Human;Humidity;Hybrids;Individual;Indoor environment;Influenza A virus;influenzavirus;Infrastructure;inner city;innovation;Intervention;Intervention Studies;Mandatory Reporting;Masks;Measles;Metadata;metagenomic sequencing;Metapneumovirus;Methods;Mission;Molecular Epidemiology;Morbidity - disease rate;Morbillivirus;Mumps virus;next generation sequencing;novel strategies;pandemic disease;pandemic influenza;Parainfluenza;Particulate;pathogen;Pathogenicity;Placebo Control;portability;Predictive Factor;protective behavior;public health intervention;randomized placebo controlled trial;Randomized, Controlled Trials;reconstruction;Research;respiratory;respiratory infection virus;Respiratory syncytial virus;respiratory virus;Rhinovirus;Risk;Rubella virus;sample collection;Sampling;SARS coronavirus;school environment;Schools;Source;Spain;Students;Surface;Symptoms;Temperature;Testing;Time;United States;United States National Institutes of Health;Vaccines;ventilation;Viral;Viral Genome;Viral Respiratory Tract Infection;virome;Work

PROJECT_TITLE: Molecular epidemiology of respiratory virus exposure in elementary schools

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Chronic stress plays a significant role in the development of neuropsychiatric illnesses such as depression and anxiety. Studies defining how the brain changes throughout chronic stressful experiences will be important steps towards identifying novel treatments for these disorders. This study will focus on how inhibitory circuits within the brain’s reward circuitry change during chronic stress.

PI_NAMEs: POLTER, ABIGAIL MARIE (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Acute;acute stress;Address;Affect;Anhedonia;Animals;Anxiety;Anxiety Disorders;Aversive Stimulus;Behavior;Behavioral;behavioral response;biological adaptation to stress;Brain;Cells;Chronic;Chronic stress;Complex;critical period;Development;Dimensions;Disease;dopaminergic neuron;Electrophysiology (science);experience;experimental study;Exposure to;Female;Fiber;gamma-Aminobutyric Acid;Goals;Health;hedonic;Hyperactivity;in vivo;Individual;Individual Differences;insight;interdisciplinary approach;Link;male;Measures;Mediating;Mediator;Mental Depression;mesolimbic system;Mood Disorders;Neurobiology;Neurons;neuropsychiatry;novel;optogenetics;Outcome;Photometry;Physiology;Play;Positioning Attribute;Process;Regulation;response;reward circuitry;Rewards;Role;sex;Shapes;Signal Transduction;Slice;social;Stimulus;Stress;Stressful Event;stressor;Synapses;System;Testing;therapeutic development;Ventral Tegmental Area;Work

PROJECT_TITLE: VTA microcircuit dynamics during chronic stress


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative The proposed project seeks to expand and pilot a status neutral online-linked mobile HIV/STI testing and care linkage strategy for Black gay, bisexual and other men who have sex with men (MSM) at high risk for HIV acquisition or transmission. This project is relevant to public health because Black MSM are disproportionately impacted by the HIV epidemic, but rates of HIV testing, care linkage to HIV pre-exposure prophylaxis (PrEP) and treatment remain disproportionately low in this priority population. Our proposal aligns with the goals of the Ending the HIV Epidemic federal initiative by developing an innovative, strategic and tailored approach to effective HIV diagnosis, treatment and prevention for high risk Black MSM and has the potential to inform public health strategies prioritizing Black MSM by reaching both those at high risk for acquisition and transmission.

PI_NAMEs: FIELDS, ERROL L (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: 18 year old;acceptability and feasibility;Advertisements;Affect;Age;Baltimore;barrier to care;Bisexual;black men who have sex with men;Black race;Caring;Clinic;Communication;Communities;community advisory board;community based participatory approach;community engaged approach;community engagement;community organizations;comorbidity;Cybersex;Data;Development;Diagnosis;Effectiveness;Ensure;Epidemic;Etiology;Event;experience;Exposure to;Focus Groups;Gays;Goals;Health;Healthcare;high risk;high risk men;high risk population;HIV;HIV diagnosis;HIV disparities;HIV Infections;HIV Seronegativity;HIV Seropositivity;Human immunodeficiency virus test;informant;innovation;Interruption;Interview;Lesbian Gay Bisexual Transgender Queer;Link;meetings;member;men;men who have sex with men;Newly Diagnosed;Outcome;Outcome Measure;Participant;participant interview;patient-level barriers;personalized approach;Pilot Projects;Population;Population Surveillance;pre-exposure prophylaxis;Prevention;Privatization;Public Health;Quasi-experiment;Race;racial disparity;recruit;Reporting;Reproducibility;Research;Risk;satisfaction;Sexual Health;Sexual Partners;Sexually Transmitted Diseases;standard of care;Stigmatization;surveillance data;Surveys;Syphilis;Testing;testing services;Time;Translating;transmission process;Work

PROJECT_TITLE: Expanding "Safe Spaces 4 Sexual Health," a Mobile Van HIV/STI Testing and Care Linkage Strategy, for Black MSM in online spaces

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Infectious Diseases;Precision Medicine;Radiation Oncology;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: Human papillomavirus (HPV)-associated oropharyngeal cancer (OPC) treated with a high dose of radiation (70 Gy) has an excellent chance to be cured, but the high radiation dose has significant side effects. The goal of this proposal is to evaluate how well a significantly reduced dose of radiation (30 Gy) can control and cure cancer in certain patients with HPV-positive OPC. These patients will be selected based on the level of oxygen in their tumors, as tumors with low levels of oxygen (hypoxia) often do not respond as well to radiation treatment as those with higher levels of oxygen; and in patients without hypoxic tumors, evidence has shown that the reduced dose of radiation may work just as well and without the severe side effects.

PI_NAMEs: LEE, NANCY Y (contact)

PROGRAM_OFFICER_NAME: VIKRAM, BHADRASAIN

PROJECT_TERMS: Aftercare;American Joint Committee on Cancer;Beds;Biological;Biological Markers;biomarker discovery;Cancer Biology;cancer classification;Cancer Patient;candidate identification;Cellularity;Cetuximab;chemoradiation;chemotherapy;Cisplatin;Clinical;Clinical Data;cohort;Data;Defect;Deglutition;Deglutition Disorders;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;disorder control;DNA;DNA Damage;Dose;Double Strand Break Repair;Eligibility Determination;Ensure;Excision;experience;fluorodeoxyglucose positron emission tomography;Functional disorder;Gene Expression;Gene Expression Profiling;Genes;genome sequencing;genomic signature;Genomics;Goals;HPV oropharyngeal cancer;Human Papillomavirus;Hypoxia;Image;imaging biomarker;In complete remission;Individual;Inferior;Left;Lesion;Magnetic Resonance Imaging;Malignant neoplasm of anus;Malignant Neoplasms;Measures;Methods;Molecular;Monitor;Morbidity - disease rate;Motion;Mucositis;Mutation;Nature;Neck Dissection;Nodal;non-invasive imaging;Normal tissue morphology;novel;Operative Surgical Procedures;overtreatment;Oxygen;Pathologic;Pathway interactions;Patient Selection;patient stratification;Patients;personalized approach;PET/CT scan;Pilot Projects;pilot trial;Positron-Emission Tomography;Postoperative Period;pre-clinical;primary endpoint;Primary Neoplasm;Process;Prognosis;Progression-Free Survivals;quantitative imaging;Radiation;Radiation Dose Unit;radiation resistance;Radiation therapy;Radiation Tolerance;randomized trial;Research;Resolution;response;side effect;Statistical Models;Structure;Survival Rate;Tissues;tool;Toxic effect;Treatment outcome;treatment response;Treatment-related toxicity;tumor;tumor hypoxia;tumor microenvironment;Virus Integration;Virus Replication;whole genome;Work

PROJECT_TITLE: A personalized approach using hypoxia resolution to guide curative-intent radiation dose reduction to 30 Gy: A novel de-escalation paradigm for HPV-associated oropharynx cancers

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Hypertension affects over half of black adults in the United States – more than any other group – and unhealthy diet is the primary determinant of disparities in hypertension among black adults. While the DASH diet is a proven strategy for lowering blood pressure in black adults, diet disparities are increasing in urban food deserts due to poor access, high cost, and cultural dissonance related to DASH meals. Our proposed clinical trial will establish the efficacy of a scalable, patient-centered solution: dietitian-assisted, DASH grocery delivery via an online, vir- tual grocery store (AmazonFresh) to black adults in urban food deserts; we include a dedicated post-trial obser- vation period to determine facilitators and barriers to sustained effects among this high-risk population.

PI_NAMEs: JURASCHEK, STEPHEN P (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Address;Adherence;Adult;Affect;Behavior;behavioral economics;Black race;Blood Pressure;blood pressure elevation;blood pressure reduction;Boston;Calories;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;Cessation of life;Cholesterol;Clinical;Clinical Trials;Collaborations;Communities;community based participatory research;community clinic;Consultations;Consumption;cost;Coupling;Custom;Dairying;DASH diet;Dedications;Diet;dietary;Dietary Intervention;Dietitian;Disparity;disparity elimination;Drops;Eating;economic determinant;Education;efficacy evaluation;efficacy trial;Enrollment;Ethnic Population;Fatty acid glycerol esters;feeding;feeding plan;Food;food desert;food preparation;Food Selections;Frequencies;Fruit;fruits and vegetables;geographic barrier;Goals;Health;health disparity;Health Food;Healthy Eating;high risk population;Home;Hypertension;hypertension control;improved;Income;income disparities;Individual;Inequality;innovation;Institution;Intake;Intervention;Knowledge;LDL Cholesterol Lipoproteins;Low income;low socioeconomic status;Meat;Methods;National Institute on Minority Health and Health Disparities;novel;nutrition;optimism;Outcome;Participant;patient oriented;Patient Self-Report;Pattern;Pharmaceutical Preparations;Pilot Projects;Policies;post intervention;Potassium;premature;Preparation;prevent;primary outcome;Qualitative Methods;racial population;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;Reduce health disparities;Research;Research Personnel;Risk Factors;Risk Reduction;saturated fat;Self Direction;skill acquisition;skills;socioeconomics;Sodium;Source;Strategic Planning;Stroke;sugar;Supermarket;sweetened beverage;Taste Perception;Technology;Testing;Thinness;Translations;trend;Unhealthy Diet;United States;uptake;Urban Community;urban dwelling;Urine;Vegetables;virtual;vulnerable community;Vulnerable Populations

PROJECT_TITLE: Effects of DASH Groceries on Blood Pressure in Black Residents of Urban Food Deserts

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Human Genome;Women's Health Research

ORG_CITY: SAN ANTONIO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: NARRATIVE BRCA1-BARD1 and BRCA2 are involved in DNA double-strand break repair and replication fork preservation by homology-directed DNA repair (HDR). Our research project strives to elucidate the functions of these factors and their associated HDR partner proteins in the execution of key HDR stages. This is now possible because we have developed robust systems to obtain highly quality protein preparations for mechanistic workup. As such, we are well positioned to leverage our expertise in biochemistry, biophysics, structural biology, and cell biology to fill knowledge gaps regarding HDR mechanisms and regulation in human. The information that will emanate from our work has strong health relevance, as DNA repair deficiency is associated with aging, neurological disorders, infertility, and cancer.

PI_NAMEs: ZHAO, WEIXING WILSON (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Address;Affect;Affinity;Aging;ATP phosphohydrolase;Attenuated;Bacteria;BARD1 gene;Binding;Biochemical;Biochemistry;Biological Assay;Biophysics;brca gene;BRCA1 gene;BRCA2 gene;Breast;Catalysis;Cells;Cellular biology;Chemicals;Chromatids;Chromatin;Chromosomes;cofactor;Complex;DNA;DNA Binding;DNA Double Strand Break;DNA fiber assay;DNA Maintenance;DNA Mimicry;DNA Repair;DNA Repair Disorder;DNA Repair Gene;DNA replication fork;Double Strand Break Repair;ds-DNA;Eukaryota;Excision;Filament;Genetic Recombination;Genome;Health;Human;Impairment;Infertility;Invaded;Joints;Knowledge;Laboratories;Lesion;Licensing;Maintenance;Malignant Neoplasms;Mammals;Mammary Neoplasms;Mediating;Mediator;Modeling;Molecular;mutant;Nervous System Disorder;novel;Nucleoproteins;Nucleosomes;Organ;ovarian neoplasm;Ovary;PALB2 gene;Play;Positioning Attribute;Postdoctoral Fellow;Preparation;preservation;presynaptic;Process;protein complex;Proteins;Publishing;Rad51 recombinase;Radiation;Reaction;reconstitution;Regulation;Research Project Grants;Role;Saccharomyces cerevisiae;Saccharomycetales;Sequence Homologs;single molecule;Single-Stranded DNA;Source;SS DNA BP;Stress;structural biology;Structure;Synapses;synergism;System;Tail;Testing;Tumor Suppressor Proteins;tumorigenesis;Work

PROJECT_TITLE: Genome Maintenance via the BRCA-RAD54 Axis

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Genetics;Human Genome;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

ORG_STATE: PA

PHR: Project Narrative Management of gastrointestinal stromal tumor has been transformed by the identification of activating mutations in the receptors KIT and PDGFRA, and the clinical application of imatinib mesylate (IM) and other tyrosine kinase inhibitors (TKIs) in the advanced disease setting. The success of these TKIs for advanced GIST has been tempered by the reality that treatment only increases the median time to tumor progression by two years in most patients. This proposal uses a multi-pronged approach to leverage impressive preliminary data towards the goal of delivering improved treatment of GIST, specifically in both preventing and/or overcoming therapeutic resistance.

PI_NAMEs: RINK, LORI  (contact);VON MEHREN, MARGARET

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Acute Myelocytic Leukemia;advanced disease;avapritinib;Biological Assay;cancer genome;Cell Cycle;Cell Cycle Checkpoint;Cell Physiology;Cell Survival;Cells;chemotherapy;chromatin remodeling;Clinical;clinical application;Clinical Research;Clinical Trials;Combined Modality Therapy;Data;Development;Disease Resistance;DNA biosynthesis;DNA Damage;DNA damage checkpoint;DNA fiber assay;DNA Repair;DNA replication fork;Down-Regulation;Doxorubicin;effective therapy;Evaluation;Future;G2/M Checkpoint Pathway;Gastrointestinal Stromal Tumors;Gatekeeping;Gene set enrichment analysis;Genes;genome integrity;Genome Stability;Genomic Instability;genotoxicity;Goals;homologous recombination;Hyperactivity;Imatinib mesylate;Immunofluorescence Microscopy;improved;In Vitro;in vivo;ineffective therapies;inhibitor;innovative technologies;insight;Left;Libraries;Life;loss of function;Malignant Neoplasms;Mediator;Mutagens;mutant;Mutate;Mutation;nanomolar;neoplastic cell;new therapeutic target;novel;novel therapeutics;Oncogenic;Pathway interactions;patient derived xenograft model;Patients;PDGFRA gene;PDGFRB gene;Phosphotransferases;pre-clinical;prevent;Process;Proliferating;Proteins;receptor;Refractory;Regulation;replication stress;Resistance;resistance mutation;response;restoration;Role;Serine;Signal Transduction;single molecule;Specimen;Stress;success;synergism;Technology;Testing;Therapeutic;therapy resistant;Threonine;Time;Topoisomerase-II Inhibitor;transcriptome sequencing;transcriptomic profiling;treatment strategy;tumor;Tumor Cell Line;tumor progression;Tyrosine Kinase Inhibitor;Xenograft Model

PROJECT_TITLE: Elucidating the critical role of Wee1 in GIST

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Depression;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Serious Mental Illness;Social Determinants of Health

PHR: NARRATIVE: The proposed research study will develop and implement novel methodologies to analyze DNA methylation risk scores (MRS) of time-varying childhood adversity using primary data from a large population- based cohort (the Avon Longitudinal Study of Parents and Children; ALSPAC) and summary statistics from the largest meta-analyses of time-varying childhood adversity and DNAm. Specifically, the proposed research will identify and test a set of epigenetic biomarkers that can be used to quantify prior exposures to childhood adversity and predict future risk for depression. Ultimately, findings from this study will provide a framework for the implementation of time-varying paradigms in MRS studies, as well as highlight novel biological signatures that can be used to explain and predict risk for mental illness across the life course.

PI_NAMEs: DUNN, ERIN CATHLEEN;LUSSIER, ALEXANDRE A (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Abbreviations;Adolescence;Adolescent;Adult;Affect;Age;Animal Model;Biological;Biological Factors;biomarker identification;Birth;burden of illness;Child;child depression;Childhood;childhood adversity;cohort;cost;Data;Data Set;depressive symptoms;Development;Disabling;DNA analysis;DNA Methylation;early life exposure;emerging adult;emotional abuse;epigenetic marker;Epigenetic Process;epigenome;epigenome-wide association studies;Ethnic Origin;Exposure to;Family;Financial Hardship;Functional disorder;Future;Grant;high risk;Household;Human;implementation framework;indexing;Life;Life Cycle Stages;Life Experience;Link;Long-Term Effects;Longitudinal Studies;maltreatment;maternal depression;Measures;Mediating;Mental Depression;Mental disorders;Mental Health;Meta-Analysis;Methodology;Methylation;methylation pattern;Modification;novel;novel marker;Outcome;Parents;Participant;Pathway interactions;Patient Self-Report;Persons;phenotypic data;Population;population based;Population Heterogeneity;Poverty;Prevention;programs;prospective;Psyche structure;Psychopathology;Reporting;Research;Research Project Grants;research study;response;Risk;risk prediction;socioeconomics;statistics;stressor;study population;Sum;Testing;Time;tool;Trauma;Weight;Youth

PROJECT_TITLE: Epigenetic predictors of time-varying exposures to childhood adversity and depression

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


NIH_SPENDING_CATS: Infectious Diseases;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Premature birth is a major cause of neonatal morbidity and motility and lung immaturity in these babies is a major cause. Dendritic cells (DC) are critical for surveillance of the lung against threat and we have identified previously underappreciated heterogeneity within the newborn lung dendritic cell compartment. The proposed research will perform a detailed analysis of the newborn dendritic cell compartment, focused on revealing the ontogeny and function of early-life lung DC. These studies will provide a greater understanding of the role of DC in neonatal lung diseases.

PI_NAMEs: HEADLEY, MARK BRYAN (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Acute Lung Injury;Address;Adoptive Transfer;Adult;Alveolar;Alveolar sac;Anti-viral Response;Antibacterial Response;Antigens;Biological Assay;Birth;Bone Marrow;Cell Compartmentation;Cell Lineage;cell type;Cells;Cellular Assay;Communicable Diseases;cytokine;Data;Dendritic Cells;detector;Development;Disease;engineered T cells;experimental study;Exposure to;fetal;Fetal Lung;Fetus;First Births;Future;Gases;Gene Expression Profiling;Genetic;Genetic Transcription;Growth;Hematopoiesis;Heterogeneity;Immunity;Immunologic Surveillance;In Vitro;Infant Mortality;Infection;Inflammation;insight;Investigation;Knowledge;Label;Lead;Life;Lung;lung development;lung health;Macrophage;Maps;Marrow;Mediating;MHC Class II Genes;Microbe;Modeling;monocyte;Motility;mouse model;Mus;Nature;Neonatal;Neonatal lung;neonatal lung disease;neonatal morbidity;neonatal period;Newborn Infant;novel vaccines;Organ;Ovum;pathogen;Phenotype;Play;Population;Predisposition;Premature Birth;premature lungs;progenitor;protein profiling;pulmonary function;Pulmonary Inflammation;Research;Resolution;response;Role;single cell proteins;Sorting;Source;Stimulus;System;T cell differentiation;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Time;Toll-like receptors;tool;transcriptome;United States;Vaccine Design;Viral;Viral Respiratory Tract Infection;Virus;XCR1 gene

PROJECT_TITLE: Ontogeny and Function of Early-Life Pulmonary Dendritic Cells

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Immunotherapy

PHR: Project Narrative CD4 “helper” T cells are an important part of the immune system, but little is known about what role they play in immune treatments of cancer patients. We have identified CD4 T cells that specifically target cancer cells by recognizing common cancer mutations found in multiple patients. We propose to treat patients by transferring CD4 T cells that recognize this mutation, and in the process learn more about how CD4 T cells might work in fighting cancer.

PI_NAMEs: VEATCH, JOSHUA R (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Address;Adoptive Cell Transfers;Adoptive Immunotherapy;Adoptive Transfer;Alleles;Amino Acids;Antigen Presentation;Antigen-Presenting Cells;antigen-specific T cells;Antigens;antitumor effect;Autologous;Biopsy;BRAF gene;cancer cell;cancer infiltrating T cells;Cancer Patient;cancer therapy;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Clinical;Clinical Trials;Correlative Study;dimensional analysis;driver mutation;engineered T cells;Epidermal Growth Factor Receptor;exhaustion;experience;fighting;first-in-human;Frequencies;Heterogeneity;high dimensionality;Histocompatibility Antigens Class II;HLA Antigens;Human;Immune;immune activation;immune checkpoint blockade;Immune response;Immune system;Immunologics;Immunotherapy;in vivo;Infiltration;Inflammation;insight;Knowledge;KRAS2 gene;Learning;Major Histocompatibility Complex;Malignant Neoplasms;Measures;Mediating;Melanoma;migration;Minority;mouse model;Mutate;Mutation;neoantigens;neoplastic cell;Oncogenic;Patient Transfer;Patients;Peptides;Phase I Clinical Trials;Phenotype;Play;Population;Process;protein complex;Recurrence;response;RNA analysis;Role;Safety;Sampling;Signal Transduction;single cell analysis;single-cell RNA sequencing;Site;Solid Neoplasm;Specificity;Surface;T cell response;T-Cell Receptor;T-Lymphocyte;Techniques;Therapeutic;Therapeutic Effect;transcriptome;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;Tumor-Infiltrating Lymphocytes;Work

PROJECT_TITLE: Therapeutic applications of CD4+ T cells specific for oncogenic driver mutations

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Rare Diseases;Sexually Transmitted Infections;Telehealth

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Despite an increase in home specimen self-collection for bacterial sexually transmitted infection (STI) screening in studies conducted with diverse populations, and the demonstrated promise of telehealth in managing mental health and improving antiretroviral therapy adherence in people living with HIV, no studies have combined home specimen self-collection with live audio/video (AV) conferencing to deliver motivational interviewing (MI), a client-centered, strengths-based counseling approach. Our sequential explanatory mixed-methods study seeks to explore the feasibility and acceptability of a novel MI-based telehealth intervention to engage sexually active gay, bisexual and other men who have sex with men living with HIV (GBMSM-LWH) in gonorrhea (GC), chlamydia (CT) and syphilis screening. Our intervention is a package of 3 components: (i) a pre-test live AV conferencing session involving an MI-guided discussion to elicit awareness of bacterial STIs and fill any knowledge gaps, bolster the perceived importance of regularly screening for GC, CT and syphilis, and improve self-efficacy for specimen self-collection, (ii) self-collecting at home and returning by mail a finger-stick blood sample (for syphilis testing), a urine sample (for GC and CT testing), a pharyngeal swab (for GC and CT testing) and a rectal swab (for GC and CT testing), and (iii) a post-test live AV conferencing session involving an MI- guided discussion to prepare participants for receiving test results and formulate personalized action plans for seeking treatment (if warranted) and repeat testing.

PI_NAMEs: SHARMA, AKSHAY  (contact)

PROGRAM_OFFICER_NAME: CHUANG, ELEANORE JENNIFER

PROJECT_TERMS: acceptability and feasibility;Anatomy;antiretroviral therapy;Attitude;Awareness;Behavioral;Bisexual;Blood specimen;Caring;CD4 Lymphocyte Count;Centers for Disease Control and Prevention (U.S.);Chlamydia;Client;Clinic Visits;Clinical Trials;Collection;computed tomography screening;Counseling;COVID-19 pandemic;Data;Diagnosis;Early Diagnosis;Early treatment;Epididymitis;Evaluation;Fingers;Fright;Gays;Gonorrhea;Health;Height;HIV;Home;improved;indicated prevention;Individual;Infection;Inflammatory;Intervention;Interview;intrinsic motivation;Knowledge;Left;Medical;men who have sex with men;Mental Health;Methods;Modeling;Monitor;Motivation;motivational enhancement therapy;national surveillance;novel;Orchitis;Participant;Patients;Perception;Persons;Pharyngeal structure;pharyngeal swab;Phase;Population Heterogeneity;Prevention;Privacy;Problem Solving;Proctitis;prostatitis;Provider;Public Health;Recommendation;recruit;Rectum;Reporting;Research;Risk;Sampling;screening;screening guidelines;Self Efficacy;Seminal;Sex Behavior;sexual health intervention;sexual HIV transmission;Sexual Partners;sexually active;Sexually Transmitted Diseases;Site;skills;social networking website;Specimen;Stigmatization;surveillance data;Swab;Syphilis;Syphilis Serodiagnosis;telehealth;Test Result;Testing;therapy adherence;Time;Ulcer;United States;Urethra;Urine;Videoconferencing;Viral;Viral Load result

PROJECT_TITLE: Feasibility and Acceptability of an MI-based Telehealth Intervention for Bacterial STI Screening

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease

ORG_CITY: Chicago

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Reductions in kidney blood flow can lead to permanent damage to the kidneys, known as chronic kidney disease, which can progress to complete loss of kidney function and can shorten life span. We propose to investigate whether information about kidney blood flow that we will obtain from contrast enhanced ultrasound will help identify which individuals with chronic kidney disease are at high risk of experiencing progressive loss of kidney function. The high-risk individuals can then be included in future clinical trials to test new treatments for chronic kidney disease.

PI_NAMEs: SRIVASTAVA, ANAND  (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Affect;Age;Animals;Atrophic;Biological Markers;biomarker development;biomarker evaluation;biomarker selection;biomarker validation;Blood flow;Blood Vessels;Cardiovascular Diseases;cardiovascular disorder risk;career development;Chronic;Chronic Kidney Failure;Clinical;Clinical Trials;clinically relevant;Collaborations;contrast enhanced;Contrast Media;Data;Data Analyses;Development;Development Plans;Disease;disease phenotype;Disease Progression;End stage renal failure;Enrollment;Environment;Erythrocytes;Evaluation;experience;Fibrosis;Functional Imaging;Future;Gases;Glomerular Filtration Rate;glomerulosclerosis;Goals;Grant;Health;healthy volunteer;high risk;high risk population;Histopathology;human data;Hypoxia;Image;Image Analysis;imaging biomarker;imaging modality;improved;Individual;Injury;interstitial;Investigation;Iohexol;Japanese;Kidney;kidney biopsy;Kidney Diseases;kidney fibrosis;Lead;learning strategy;Lesion;life span;Link;Measures;Mentors;Mentorship;Microbubbles;Microcirculation;Microvascular Dysfunction;mortality;Motion;Multicenter Studies;multidisciplinary;non-invasive imaging;novel;novel therapeutics;Outcome;Pathogenesis;patient oriented research;Patients;Performance;Perfusion;Population;Positioning Attribute;premature;prognostic value;Property;prospective;Proteinuria;Protocols documentation;recruit;Renal Blood Flow;renal damage;Renal function;Reporting;Research;Research Personnel;research study;Risk;skill acquisition;skills;study population;Testing;Time;tool;Training;Translations;Tubular formation;Ultrasonography;ultrasound;Universities

PROJECT_TITLE: Non-Invasive Imaging Biomarkers to Identify a High-Risk Chronic Kidney Disease Phenotype

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Project Narrative Neighborhood context may play an important role in shaping existing inequities in obesity and diabetes. This study leverages a $50 million housing experiment to examine whether low-income adults given support to move to a lower-poverty neighborhood experience reductions in obesity and diabetes risk compared to similar adults not given these moving supports and explores potential mechanisms through which these reductions may occur. It further investigates whether children whose families are given the support to move experience changes in obesity.

PI_NAMEs: POLLACK, CRAIG EVAN (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: Accelerometer;Address;Adult;adult obesity;American;Area;arm;Behavioral;Body mass index;Characteristics;Child;Collaborations;Communities;Community Developments;comparison control;Congresses;contextual factors;Control Groups;cost;Data;Data Collection;Deposition;design;Diabetes Mellitus;diabetes risk;Diet;disparity elimination;Enrollment;Exhibits;experience;Experimental Designs;experimental study;falls;Family;Fees;follow-up;Food;Funding;Geography;Glycosylated hemoglobin A;Health;Health Benefit;health care availability;health disparity;health inequalities;Health Promotion;hospitalization rates;Household;Housing;implementation barriers;Inequity;innovation;Intervention;Interview;Knowledge;Life Cycle Stages;lifestyle intervention;Literature;Low income;Low Income Population;lower income families;Measures;Mediating;Mental Health;Neighborhoods;Obesity;obesity in children;obesity risk;Outcome;outreach;Participant;Pathway interactions;Persons;Physical activity;Play;Policies;Poverty;Poverty Areas;Prediabetes syndrome;Prevalence;programs;psychosocial;Psychosocial Factor;Questionnaires;racial discrimination;racial disparity;racism;Randomized;Randomized, Controlled Trials;recruit;Research;Resources;Role;Sampling;Security;segregation;Services;Shapes;Site;Sleep;social;Social support;Social Work;socioeconomic disparity;structural determinants;Structural Racism;Surveys;Testing;Time;treatment group;U.S. Department of Housing and Urban Development;violence exposure;voucher;walkability

PROJECT_TITLE: The Mobility Opportunity Voucher to Eliminate Disparities (MOVED) Study: Obesity and Diabetes Risk in HUD's Community Choice Demonstration


NIH_SPENDING_CATS: Cancer;Immunotherapy;Lung;Lung Cancer

PHR: PROJECT NARRATIVE KRASG12D inhibitors are currently entering clinical testing for various malignancies including non-small cell lung cancer (NSCLC), but the development of resistance to these treatments—and therefore tumor relapse—is anticipated. To address the need for treatments that will produce long- term responses, we will investigate how resistance in KRASG12D-mutant NSCLC tumors is linked to remodeling of the lung cancer tumor microenvironment (TME). Describing these processes in the TME will provide actionable biomarkers and therapeutic targets in relapsed tumors that will inform the development of future treatments with long-term effectiveness for NSCLC patients.

PI_NAMEs: GALBAN, STEFANIE  (contact);PASCA DI MAGLIANO, MARINA

PROGRAM_OFFICER_NAME: BOURCIER, KATARZYNA

PROJECT_TERMS: Address;anti-PD-L1;anti-PD-L1 antibodies;anti-PD-L1 therapy;Biological Assay;Biological Markers;Cancer Model;Cancer Patient;Cells;checkpoint therapy;Clinic;Clinical;Clinical Trials;Coculture Techniques;Complement;cytokine;Cytometry;Data;Development;effective therapy;Effectiveness;efficacy evaluation;experimental study;Extracellular Matrix;Fibroblasts;Future;Genes;Goals;immune activation;immune checkpoint;Immune checkpoint inhibitor;Immunohistochemistry;immunological status;Immunotherapy;Infiltration;inhibitor;Intervention;KRAS oncogenesis;KRAS2 gene;KRASG12D;Link;Lung;Malignant neoplasm of lung;Malignant Neoplasms;Modeling;Molecular;molecular targeted therapies;mouse model;Mus;mutant;Mutation;Myeloid Cells;never smoker;Non-Small-Cell Lung Carcinoma;Oncogenes;Oncogenic;Organoids;outcome prediction;Patients;PD-1/PD-L1;PDL1 inhibitors;Phase;Preclinical Testing;Process;programmed cell death ligand 1;Recurrent tumor;Relapse;research clinical testing;Resistance;Resistance development;resistance mechanism;Resources;response;Role;Signal Pathway;single-cell RNA sequencing;Smoker;targeted treatment;Techniques;Technology;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapy resistant;Time;TP53 gene;treatment strategy;tumor;tumor microenvironment;Tumor Suppressor Proteins;Tumor-Associated Process

PROJECT_TITLE: The Role of the Tumor Microenvironment in Resistance to Oncogenic KRAS Inhibition in Lung Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-9 (O2)]


NIH_SPENDING_CATS: Digestive Diseases

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative The intestinal epithelium houses crucial stem cells in crypts that expand during early development and repair after damage in a process called crypt fission. Intestinal stem cells are sustained by a surrounding mesenchyme called “the niche”; what role the niche plays in mediating crypt fission is unknown. The studies will improve understanding of how interactions between the epithelium and niche sustain proper organ growth in development and repair, and help develop future treatments to diseases such as necrotizing enterocolitis and inflammatory bowel disorders.

PI_NAMEs: MCCARTHY, NEIL  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Ablation;Adult;Anatomy;Biological Assay;Biology;cell type;Cells;Coculture Techniques;Data;Derivation procedure;Development;Disease;EGF gene;Ensure;Environment;epithelial repair;Epithelium;experimental study;Failure;Future;Genetic;Growth;healing;Health;Homeostasis;improved;In Vitro;in vivo;Inflammatory Bowel Diseases;inhibitor;insight;intestinal crypt;intestinal epithelium;Intestines;irradiation;Location;Maintenance;Mediating;Mesenchymal;Mesenchyme;Methods;Microscopy;Molecular;Molecular Profiling;Mus;Myofibroblast;Natural regeneration;Necrotizing Enterocolitis;novel;Operative Surgical Procedures;organ growth;Organoids;Pathway interactions;PDGFRA gene;Phenotype;Play;Population;postnatal development;Process;Recombinants;regenerative tissue;Regulation;repaired;Resolution;Role;Signal Transduction;Site;Smooth Muscle;Source;stem;stem cell expansion;stem cell homeostasis;stem cells;Testing;Therapeutic;Tissues;Whole-Body Irradiation;WNT Signaling Pathway

PROJECT_TITLE: The role of the mesenchymal niche in intestinal crypt fission

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Oxidative stress emanating from endogenous sources and genotoxic environmental exposures is a causative agent of DNA damage that is linked to inflammation, age-related diseases and cancer in humans. This proposal will utilize a novel tool to induce singlet oxygen mediated base damage in human cells specifically at telomeres, at endogenous gene promoters or throughout the genome, to study the specific impact of 8-oxoguanine lesion processing on the regulation of transcriptional responses to genotoxic oxidative damage. The project is therefore relevant to understand the crosstalk between repair of oxidative damage and gene expression, and their role in human disease.

PI_NAMEs: DE ROSA, MARIAROSARIA  (contact)

PROGRAM_OFFICER_NAME: HEACOCK, MICHELLE

PROJECT_TERMS: Acute;Adopted;Affect;age-related disease;Aging;Air Pollution;Applied Skills;ATAC-seq;base;Base Excision Repairs;Binding;Biological;Cell Aging;Cell Physiology;Cells;Cellular Structures;Chemicals;Chimeric Proteins;Chromatin;chromatin immunoprecipitation;Chromosomes;Coupling;Data;deactivated CRISPR-Cas9;Development;Disease;DNA;DNA Adducts;DNA Damage;Dyes;endonuclease;Environmental Exposure;Epigenetic Process;epigenome;experimental study;Exposure to;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic Transcription;Genome;genome-wide;Genomic Segment;Genomics;genotoxicity;Goals;Guanine;Histone Code;histone modification;Homeostasis;Hot Spot;Human;human disease;In Vitro;Individual;Inflammation;Inflammatory;Knock-out;Knowledge;Length;Lesion;Light;Link;Maintenance;Malignant - descriptor;Malignant Neoplasms;Mediating;Mentors;Modeling;Modification;Mutagenesis;NEIL3 gene;Northern Blotting;novel;Nucleic Acid Regulatory Sequences;Nucleoproteins;Organ;Outcome;Oxidants;oxidation;Oxidation-Reduction;oxidative damage;Oxidative Stress;Oxidative Stress Induction;Peptides;Phase;Phenotype;Photosensitizing Agents;Play;Predisposition;Prevention;Production;promoter;Promoter Regions;Publications;Reactive Oxygen Species;recruit;repair enzyme;repaired;Reporter;Reporting;Research;Research Proposals;Resources;response;RNA;Role;senescence;Singlet Oxygen;Smoking;Source;System;Technical Expertise;telomere;Telomere Maintenance;Telomeric Repeat Binding Protein 1;TERF1 gene;Testing;tool;Training;Transcript;Transcription Elongation;transcription factor;Transcriptional Activation;Transcriptional Regulation;transcriptome;transcriptome sequencing;Universities;Untranslated RNA;Variant;vector;Writing

PROJECT_TITLE: Investigating roles for oxidative guanine damage in transcription regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 BWD-D (K9)]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: PSYCHIATRY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative The proposed project leverages a unique longitudinal cohort of over 6 million individuals to examine the extent to which posttraumatic stress disorder (PTSD), a psychiatric disorder that can develop after trauma exposure, is associated with incident type 2 diabetes and poor glycemic control in individuals who developed type 2 diabetes during the study period. This study also will investigate the extent to which associations between PTSD and type 2 diabetes differ across sex, race, and ethnicity. This work has the potential to advance our knowledge about factors that contribute to type 2 diabetes risk and ultimately may have implications for tailoring diabetes-related prevention and intervention efforts for individuals with PTSD.

PI_NAMEs: SERIER, KELSEY NICOLE (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: Address;Adult;Attention;Autonomic Dysfunction;Award;Behavioral Sciences;Biological;Black race;burden of illness;career;Chronic;cohort;comorbid depression;comorbidity;comparison group;cost;Cox Proportional Hazards Models;Data;Data Analyses;Data Sources;design;Development;Diabetes Mellitus;Diabetes prevention;diabetes risk;diabetes self-management;Diagnosis;Diagnostic;Electronic Health Record;Endocrinology;Environmental Risk Factor;Epidemiologic Methods;Epidemiology;ethnic identity;ethnic minority population;Ethnic Origin;Exposure to;follow-up;food insecurity;Foundations;Future;glycemic control;Glycosylated hemoglobin A;Goals;Grant;Health;Health Care Costs;Hispanic;Homelessness;Incidence;Individual;Intervention;Investigation;Knowledge;Laboratories;Latino;Link;Literature;Logistic Regressions;Longitudinal cohort;Longitudinal Studies;Measures;Medical;Mental Depression;Mental disorders;Mental Health;Mentored Clinical Scientist Development Award (K08);Mentorship;Methodology;minority health;Modeling;modifiable risk;Modification;Morbidity - disease rate;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;Outcome;Pathway interactions;Patient Self-Report;people of color;physical conditioning;poor sleep;Post-Traumatic Stress Disorders;Prevalence;Prevention;programs;prospective;psychiatric comorbidity;psychologic;Psychosocial Factor;Public Health;Public Health Informatics;Race;racial diversity;racial identity;racial minority population;Research;Research Personnel;Risk;Risk Factors;Role;Sampling;Science;Series;sex;skills;social factors;Subgroup;Surveys;Testing;Time;Training;Trauma;trauma exposure;traumatic stress;United States;Variant;Veterans;Veterans Health Administration;Woman;Women's Health;Work;Writing

PROJECT_TITLE: Longitudinal Associations of Posttraumatic Stress Disorder with Incident Type 2 Diabetes and Poor Glycemic Control in a Large National Cohort

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Comparative Effectiveness Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Data Science;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention;Suicide

PHR: Project Narrative The United States is experiencing a crisis in mental health care, with overcrowding and delayed mental health care in emergency departments (EDs) exacerbated by the COVID-19 pandemic and with differential impacts on vulnerable populations. In this study, I will analyze ED visits for psychiatric care in a large regional health system, developing: 1) a transdiagnostic subtyping system to track trends in patient mixes, 2) machine learning models to predict ED utilization and post-discharge adverse events (suicide attempt, overdose, or psychotic episode), 3) a precision treatment rule for primary ED disposition decisions on adverse psychiatric events. By combining a large observational database with data science methods, this project will provide unique insights into modifiable risk and resilience factors, opportunities for personalized treatment approaches, and will inform the effective delivery of mental health services, contributing to mental health equity for vulnerable populations.

PI_NAMEs: KENNEDY, CHRISTOPHER JAMES (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Accident and Emergency department;Acute;Address;Admission activity;Adverse event;adverse event risk;Agitation;Ambulatory Care;Ambulatory Monitoring;Anxiety;Appointment;Area;autoencoder;Automated Clinical Decision Support;Award;Beds;Big Data;Birds;Calibration;career development;Caring;Categories;Characteristics;Chest Pain;Clinical;clinical care;clinical decision-making;Complex;Computing Methodologies;Continuity of Patient Care;Coupled;COVID-19 pandemic;COVID-19 pandemic effects;Crowding;Data;Data Analyses;Data Science;Databases;Day Care;Decision Making;deep learning;density;Development;Diagnosis;Diagnostic;Discrimination;Electronic Health Record;Emergency Care;Emergency department visit;emergency settings;Emergency Situation;Environment;Ethnic Origin;Event;experience;Fatigue;Future;General Hospitals;Goals;Grant;Grouping;Growth;Health;health care quality;health equity;Health Status;Health system;Healthcare Systems;hospital readmission;Hospitalization;Hospitals;Hybrids;Iatrogenesis;implementation science;improved;indexing;Inpatients;insight;Intervention;Jordan;Label;Leadership;Learning;Length of Stay;Machine Learning;machine learning model;Massachusetts;medical schools;Mental Depression;mental disorder prevention;Mental disorders;Mental Health;Mental Health Services;Mentors;Mentorship;Methods;Modeling;modifiable risk;National Institute of Mental Health;Nature;neural network;New England;novel;Outcome;outpatient programs;Outpatients;Overdose;pandemic disease;pandemic impact;Patient Care;patient population;patient stratification;Patient-Focused Outcomes;Patients;Pattern;people of color;personalized medicine;Pharmaceutical Preparations;pragmatic trial;Precision therapeutics;predictive modeling;Preparation;Procedures;programs;Provider;psychiatric emergency;Psychiatric therapeutic procedure;Psychiatry;Psychological reinforcement;Psychometrics;Psychopathology;psychotic;Race;Research;Research Proposals;resilience factor;Resources;Risk;Risk Factors;Series;Services;Social isolation;Statistical Methods;statistics;Stress;Structure;Subgroup;Suicide attempt;Suicide prevention;support tools;System;Taxonomy;Testing;Therapeutic;Time;tool;Training;treatment effect;treatment optimization;treatment planning;treatment response;treatment strategy;trend;Uninsured;United States;United States Substance Abuse and Mental Health Services Administration;unsupervised clustering;Visit;Vulnerable Populations;Work;Writing;Youth

PROJECT_TITLE: Improving emergency psychiatric care through machine learning, causal inference, and psychometrics

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ORG_CITY: NEW HAVEN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: 8. PROJECT NARRATIVE Complement may be activated by multiple mechanisms, such as ischemia reperfusion injury or anti-donor antibodies, depositing membrane attack complexes (MACs) on the surface of the endothelial cells (ECs) that line the blood vessels of the graft. Graft ECs internalize MACs, triggering a complex and incompletely understood process that results in expression of IL-15 on the EC surface facing the blood where it can boost the activation of circulating host T lymphocytes and result in graft rejection. In this Exploratory/Development (R21) grant, we propose to elucidate the complex regulation of IL-15 cell surface expression in human ECs (aim 1) and optimize a genetic therapy approach (aim 2) that can be adapted to block this process in human organs undergoing pre-transplant ex vivo machine perfusion.

PI_NAMEs: POBER, JORDAN S (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Ablation;Address;Alleles;Allografting;Antibodies;autocrine;Binding;Biological Assay;Blood;Blood Vessels;cell injury;Cell Line;Cell Nucleus;Cell surface;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;Complement Activation;Complement Membrane Attack Complex;complement system;Complex;CRISPR/Cas technology;Cycloheximide;Data;Deposition;Development;donor-specific antibody;Endothelial Cells;Epitopes;experimental study;Future;gene therapy;gene transplantation for gene therapy;Genes;Genetic Transcription;Graft Rejection;Graft Survival;Grant;Human;IL15 gene;Immune system;Immunofluorescence Immunologic;In Situ;Incidence;Infection;Inflammasome;Interferons;Interleukin-1;Interleukin-15;Kidney;kidney allograft;knock-down;Ligation;Link;Longevity;Lymphocyte;Mediating;Messenger RNA;MicroRNAs;Natural Killer Cells;Nuclear;Organ;Organ Transplantation;overexpression;paracrine;Pathway interactions;Perfusion;Perioperative;post-transplant;preservation;prevent;Process;protein expression;Protein Isoforms;Proteins;Publishing;Regulation;Reperfusion Injury;response;Rest;RNA;Severities;Small Interfering RNA;Stains;Stimulus;Surface;T-Lymphocyte;Therapeutic;TNF gene;Transcript;Transfection;Translations;Transplantation;uptake;Virus Diseases;Work

PROJECT_TITLE: Targeting complement-induced IL-15 trans-presentation by human endothelial cells

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Chronic Pain;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Neurosciences;Pain Research

ORG_DEPT: DENTISTRY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Pulpitis, or inflammation of the dental pulp tissue, is a debilitating painful disease and one of the main causes of invasive dental procedures. In this project, we investigate the roles of neutrophils in sensory afferent injury and pain and the role of sensory neurons in modulating innate immune response in pulpitis. The project is relevant to NIDCR’s mission because of its potential to improve dental health by investigating neuro-immune mechanisms driving dental pain and inflammation.

PI_NAMEs: ERDOGAN, OZGE  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Affect;Afferent Neurons;Anatomy;Animal Model;antagonist;Automobile Driving;Award;Bacteria;Behavior;Biological Assay;Biology;Calcitonin Gene-Related Peptide;career development;Cells;Clinical;Clinical Protocols;Complex;Cues;cytokine;Dental Care;Dental caries;Dental Pulp;Dental Pulp Capping;Dentists;designer receptors exclusively activated by designer drugs;Development;Diagnostic;diagnostic strategy;Disease;Disease Progression;Economic Burden;Electric Stimulation;Enzyme-Linked Immunosorbent Assay;Face;Flow Cytometry;Fusobacterium periodontium;Future;Genes;Genetic;Genetic Transcription;Goals;Grant;Hypersensitivity;Image;Immune;improved;In Situ Hybridization;in vivo;in vivo Model;Inflammation;Inflammatory;Inflammatory Response;Injury;Innate Immune Response;insight;Investigation;Knowledge;Learning Skill;Mechanics;Mediating;Mentors;Mentorship;Mission;Modeling;Molecular;Mus;National Institute of Dental and Craniofacial Research;Nerve Endings;nerve injury;Nerve Pain;nerve supply;Neuroanatomy;Neuroimmune;neuroimmunology;Neuroimmunomodulation;Neurons;Neuropeptides;Neurosciences;neutrophil;Neutrophil Infiltration;Nociception;Nociceptors;novel;novel diagnostics;Oral health;Outcome;Pain;pain behavior;Pain management;pain outcome;Peptide Signal Sequences;Periodontium;pharmacologic;Phase;Prevalence;Principal Investigator;Procedures;Pulp Canals;Pulpitis;Recovery;Research;response;Role;Root Canal Therapy;Scientist;Sensory;Signal Transduction;single nucleus RNA-sequencing;social;Sodium Channel;Techniques;Tissues;Tooth Diseases;Tooth Extraction;Tooth structure;Toothache;Training;Trauma;Visualization;voltage

PROJECT_TITLE: Roles of neutrophil-sensory neuron interactions in dental pulp inflammation and pain

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Genetics

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE Nonsense mediated mRNA decay (NMD) promotes the normal gene expression of unmutated messenger RNAs (mRNAs) and destroys mutated mRNAs that produce potential disease-causing proteins. The exon junction complex (EJC) is one key determinant of whether an mRNA undergoes NMD and contains the NMD factor UPF2 or the central cell-signaling protein AKT, the latter of which is promoted by insulin. This work will build upon this recent finding by defining the molecular mechanisms involved in this process, which is important because NMD and AKT signaling are both dysregulated in human diseases like Fragile X Syndrome, some cancers, and type 1 and type 2 diabetes.

PI_NAMEs: ABSHIRE, ELIZABETH TENLEY (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Address;Auxins;Binding;Biochemistry;Biology;Cell Line;Cell Nucleus;Cells;cellular engineering;cofactor;Complex;Cytoplasm;Deposition;Diabetes Mellitus;Disease;Ensure;Environment;Event;Exons;Fragile X Syndrome;Frameshift Mutation;Gene Expression;Genetic Transcription;helicase;human disease;Insulin;insulin signaling;Insulin-Dependent Diabetes Mellitus;Learning;Liquid Chromatography;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Mediating;Mentors;Messenger RNA;Molecular;Molecular Conformation;mRNA Decay;Mutate;Names;Neurodevelopmental Disorder;Non-Insulin-Dependent Diabetes Mellitus;Nonsense Mutation;Pathway interactions;Phosphorylation;Phosphorylation Site;Phosphotransferases;Play;Post-Translational Protein Processing;premature;Process;programs;protein complex;Protein-Serine-Threonine Kinases;Proteins;Proteomics;Proto-Oncogene Proteins c-akt;recruit;Regulation;Regulatory Pathway;Research;response;RNA;RNA Decay;RNA immunoprecipitation sequencing;RNA metabolism;RNA Splicing;RNA, Messenger, Splicing;Role;Serine;Signal Pathway;Signal Transduction;Site;Spliceosomes;tandem mass spectrometry;Techniques;Terminator Codon;Testing;Training;Translations;type I and type II diabetes;Uncertainty;Work

PROJECT_TITLE: Regulation of exon junction complex composition and assembly

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-8 (KR)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Contraception/Reproduction;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE This project will investigate the pathways linking pre-pregnancy cardiometabolic risk factors (hypertension, obesity and diabetes) with the development of preeclampsia and the long-term cardiovascular risks associated with preeclampsia. This work will provide insights into therapeutic strategies to mitigate cardiovascular risks of preeclampsia.

PI_NAMEs: MINHAS, ANUM  (contact)

PROGRAM_OFFICER_NAME: PRICE, CANDICE

PROJECT_TERMS: Acute;adjudication;Affect;Age;Atherosclerosis;Award;Biological Markers;Birth;Blood Vessels;Boston;cardiac magnetic resonance imaging;Cardiology;Cardiometabolic Disease;cardiometabolic risk;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular imaging;cardiovascular risk factor;Cardiovascular system;career;Chronic;Clinical;clinical database;Cluster Analysis;cohort;Cohort Studies;Coronary;Data;Development;Diabetes Mellitus;Disease;endothelial dysfunction;Endothelium;enhancing factor;Epidemiologic Methods;Epidemiologist;Epidemiology;Event;experience;Five-Year Plans;Functional disorder;Funding;Future;Generations;Goals;Grant;Heart failure;heart imaging;Heterogeneity;Human;Hypertension;Image;Imaging Techniques;Impairment;Inflammation;Inflammatory;inflammatory marker;insight;Institution;International;Ischemia;Isometric Exercise;K-Series Research Career Programs;Learning;Life Cycle Stages;Link;Machine Learning;maternal morbidity;Maternal Mortality;Measurement;Measures;Mediating;Mediator;medical schools;Mentored Patient-Oriented Research Career Development Award;Mentors;Monitor;Mothers;Myocardial Ischemia;novel;Nulliparity;Obesity;Outcome Study;Pathway interactions;Perinatal;Physicians;Play;Positioning Attribute;Postpartum Period;Postpartum Women;Pre-Eclampsia;Pregnancy;Pregnancy Outcome;prepregnancy;Prevention Guidelines;Preventive;Preventive measure;Preventive therapy;Primary Prevention;professor;Public Health Schools;Race;recruit;Reduce health disparities;Research;Research Design;Research Personnel;Research Proposals;Resources;Risk;Risk Factors;risk mitigation;Role;Sampling;Scientist;Secondary to;Serum;skills;Statistical Methods;Stress;Stroke;Subgroup;success;Testing;Therapeutic;Training;United States National Institutes of Health;Universities;Vascular Diseases;vascular endothelial dysfunction;Woman;Women's Health;Work

PROJECT_TITLE: Intersections of pre-pregnancy cardiometabolic risk factors, preeclampsia and cardiovascular disease in a lifecourse framework

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (OA)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Nanotechnology;Orphan Drug;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PHR: Conventional treatments for unresectable liver cancer are largely ineffective. The goal of this research is to develop a target nanotheranostic platform for alpha-emitting radiopharmaceutical therapy of liver cancer. If successful, it will address the unmet medical needs for the treatment of liver cancer.

PI_NAMEs: KRAITCHMAN, DARA L (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: 3-Dimensional;Address;Advanced Development;alternative treatment;Animal Cancer Model;Binding;Biodistribution;Biological;Biological Assay;bioluminescence imaging;biomaterial compatibility;blood-brain tumor barrier;Breast Cancer Model;Calcium;cancer cell;Cancer Etiology;Castration;cell killing;Cells;Cessation of life;Clinical;conventional therapy;curative treatments;cytotoxic;cytotoxicity;Diffusion;Disease Progression;Disseminated Malignant Neoplasm;DNA Damage;dosimetry;Drug Kinetics;effective therapy;Encapsulated;Excision;Exhibits;exosome;Formulation;Goals;Hepatic artery;HepG2;Human;Image;imaging modality;immunoregulation;improved;In Vitro;in vivo;innovation;Ionizing radiation;iron oxide nanoparticle;irradiation;Label;Liposomes;Liver;liver cancer model;liver cancer patient;Liver neoplasms;Magnetic Resonance Imaging;Magnetism;Malignant Epithelial Cell;Malignant neoplasm of liver;Malignant Neoplasms;Mediating;Medical;Medical Imaging;Membrane;Mesenchymal Stem Cells;Metastatic breast cancer;Metastatic Neoplasm to the Bone;Metastatic Prostate Cancer;Micrometastasis;mimetics;Modality;Modification;molecular imaging;monolayer;mouse model;nanocarrier;nanoparticle;nanotechnology platform;nanotheranostics;Nature;Neoplasm Metastasis;neoplastic cell;novel;Organ;palliative;particle;Pathway interactions;Patients;Penetration;Pharmaceutical Preparations;Primary carcinoma of the liver cells;Primary Malignant Neoplasm of Liver;Property;Radiation therapy;Radioembolization;Radiolabeled;Radiopharmaceuticals;receptor;Research;Residual Neoplasm;Resistance;resistance mechanism;Resolution;Safety;Site;Soft Tissue Neoplasms;Solid;spheroids;stem cell exosomes;success;superparamagnetism;Survival Rate;systemic toxicity;targeted delivery;Testing;theranostics;Therapeutic;Therapeutic Agents;Therapeutic Embolization;Tissues;tomography;tool;Toxic effect;transcatheter arterial chemoembolization;Transplantation;Treatment Efficacy;treatment strategy;tumor;Tumor Burden;tumor growth;tumor vascular supply;Unresectable;Vascularization;Visualization

PROJECT_TITLE: Exosome-mediated therapy for liver cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-F (O1)]


NIH_SPENDING_CATS: Aging;Biotechnology;Breast Cancer;Cancer;Clinical Research;Immunotherapy;Prostate Cancer;Urologic Diseases;Women's Health Research

PHR: PROJECT NARRATIVE This proposal explores an approach to prostate cancer immunotherapy using a monoclonal antibody that binds to a molecule on lymphocytes known as CD6, which would, distinct from currently available checkpoint inhibitors, suppress rather than instigate serious autoimmune toxicity.

PI_NAMEs: FOX, DAVID ALAN (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Activated-Leukocyte Cell Adhesion Molecule;Adhesives;Adverse event;Affinity;Aftercare;ALCAM gene;anti-cancer;Antibodies;Antigen-Presenting Cells;Autoimmune;Autoimmune Diseases;autoimmune toxicity;Autoimmunity;Binding;Biological Assay;Blocking Antibodies;Breast;cancer cell;Cancer cell line;cancer immunotherapy;cancer survival;cancer therapy;CD3 Antigens;CD6 antigen;CD8-Positive T-Lymphocytes;Cell Communication;Cell Death;cell killing;Cell Line;Cell surface;Cell Survival;Cell-Mediated Cytolysis;Cells;Cellular biology;checkpoint inhibition;checkpoint therapy;Clinical;Clinical Trials;Coculture Techniques;Color;CTLA4 gene;Cytolysis;Data;Disease;effective therapy;efficacy evaluation;Exclusion;experience;experimental study;Flow Cytometry;Gene Expression;Gene Expression Alteration;Genetic;Human;humanized mouse;imaging system;Immune;Immune checkpoint inhibitor;immunodeficiency;Immunodeficient Mouse;immunoregulation;Immunotherapy;In complete remission;In Vitro;in vivo;Infiltration;Inflammatory;Interruption;Licensing;Ligands;Lung;Lymphocyte;Lymphocyte Activation;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Mature T-Lymphocyte;Mediating;Membrane Glycoproteins;migration;Modeling;Monoclonal Antibodies;mouse model;Multiple Sclerosis;Mus;mutant;Natural Killer Cells;Neoplasm Metastasis;Non-Small-Cell Lung Carcinoma;novel strategies;Organ;Pathogenicity;Patients;Pattern;Precipitation;programmed cell death ligand 1;programmed cell death protein 1;Property;Prostate;prostate cancer cell;prostate cancer cell line;receptor;Recovery;Resistance;response;Rheumatoid Arthritis;Role;SCID Beige Mouse;single-cell RNA sequencing;SRCR proteins;Structure;Surface;System;T-Cell Depletion;T-Lymphocyte;Testing;Time;triple-negative invasive breast carcinoma;tumor;tumor microenvironment;Tumor-Infiltrating Lymphocytes;Uveitis;Xenograft procedure

PROJECT_TITLE: Immunotherapy of prostate cancer using an anti-CD6 monoclonal antibody

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-1 (O2)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Chronic Pain;Dementia;Neurodegenerative;Neurosciences;Pain Research

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative Although gabapentin has been increasingly prescribed in the older adults as off-label indication, the potential health effects of gabapentin use on older adults are not well studied. This proposal will investigate the patterns of gabapentin use in older adults, and the healthcare-related outcomes associated with gabapentin use. This study will provide healthcare providers and policymakers with a better understanding of the use and potential health outcomes associated with gabapentin use in older adults.

PI_NAMEs: OH, GYEON  (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Adult;Affect;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Analgesics;anti-depressive agents;Antipsychotic Agents;Autopsy;Behavior;behavior change;Belief;beneficiary;Benefits and Risks;Benzodiazepines;Binding Sites;biomedical informatics;Breathing;Calcium Channel;career;Central Nervous System;Central Nervous System Depressants;Characteristics;Clinical;clinically relevant;Cognition;Cognitive;Data;Data Coordinating Center;Data Reporting;Data Set;Dementia;demographics;Diagnosis;Drug Prescriptions;Drug usage;Emergency department visit;Enrollment;Ensure;evidence base;experience;fall risk;falls;Focal Seizure;Fracture;functional decline;Future;gabapentin;Goals;Grant;Health;Health Expenditures;Health Personnel;Healthcare;Hospitalization;Impaired cognition;improved;interest;Investigation;Knowledge;Label;Link;Manuscripts;Measures;Medical History;Medicare;Medicare claim;Medicine;Mentors;Methods;Migraine;mortality;Motor;motor behavior;N-Methyl-D-Aspartate Receptors;National Institute on Aging;Neurocognitive;Neuroepidemiology;neuropathology;Nursing Homes;off-label use;older adult;Opioid;Oral;Outcome;Pain;Pain management;painful neuropathy;Patient-Focused Outcomes;Pattern;Pharmaceutical Preparations;Pharmacoepidemiology;Policies;Policy Maker;Population;Postherpetic neuralgia;Preparation;Process;psychiatric symptom;Psychiatric therapeutic procedure;Recording of previous events;Reporting;Research;Risk Estimate;Role;Safety;Sample Size;Selection Bias;skills;Structural Models;Substance Use Disorder;Surveys;Thrombospondins;Time;Translating;treatment risk;trend;United States Centers for Medicare and Medicaid Services;United States Food and Drug Administration;Writing

PROJECT_TITLE: Gabapentin prescription and health-related outcomes in older adults

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: This study addresses a critical healthcare need of improving the poor survival outcomes of TNBC by inhibiting tumor expansion, tumor recurrence, and metastasis. Our long-term goal is to translate the dual inhibition of PARP and STAT3 using talazoparib and LLL12B combination as a novel therapeutic approach in both BRCA- mutant and BRCA-proficient TNBC into clinical evaluation. If successful, this novel approach can move the field of TNBC therapy forward and has a potential to improve the survival of patients.

PI_NAMEs: LIN, JIAYUH  (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: Address;Adjuvant Therapy;Affect;Antineoplastic Agents;Base Excision Repairs;Biological Availability;BRCA mutations;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Patient;breast cancer progression;Breast Cancer therapy;cancer cell;cancer therapy;Cause of Death;Cell Death;Cell Migration Inhibition function;Cell Survival;Chemoresistance;Clinic;Clinical;Combined Modality Therapy;Data;Disease Progression;Disease Resistance;DNA biosynthesis;DNA Double Strand Break;DNA Repair;efficacy evaluation;Excision;FDA approved;Generations;Goals;Healthcare;homologous recombination deficiency;Immunocompetent;Immunodeficient Mouse;improved;in vivo Model;inhibitor;inhibitor therapy;Interleukin-6;Invaded;Malignant Breast Neoplasm;Malignant Neoplasms;Medical;Modeling;mortality;mouse model;Mus;mutant;Neoplasm Metastasis;novel;novel strategies;novel therapeutic intervention;Oncogenic;Operative Surgical Procedures;Oral;orthotopic breast cancer;Outcome;Pathway interactions;Patient Care;Patients;Pharmaceutical Preparations;Phenotype;Phosphorylation;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;prevent;Primary Neoplasm;Recurrence;Recurrent tumor;Reporting;research clinical testing;Resistance;Signal Transduction;Small Interfering RNA;STAT3 gene;Supporting Cell;survival outcome;Testing;Therapeutic;therapeutically effective;therapy resistant;Translating;triple-negative invasive breast carcinoma;tumor;Tumor Expansion;tumor growth;Tumor Immunity;tumor microenvironment;tumorigenesis;Woman

PROJECT_TITLE: Dual inhibition of PARP and STAT3 as a novel therapeutic approach for triple-negative breast cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-A (O1)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Prevention;Psychosis;Schizophrenia;Serious Mental Illness;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Tobacco use is the top preventable cause of early mortality in schizophrenia, and smoking cessation treatments are significantly less effective in schizophrenia than in the general population. I determined that in schizophrenia, nicotine use is linked to disorganization in a brain network (the Default Mode Network) and used pharmacology and noninvasive neuromodulation to show that manipulating this network temporarily changes craving for nicotine. This project will determine if this network can be changed in an enduring way that leads to decreased nicotine use in schizophrenia.

PI_NAMEs: WARD, HEATHER BURRELL (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Acute;Affect;Biometry;Brain;career;career development;Cigarette;clinical efficacy;Clinical Trials;Clinical Trials Design;co-clinical trial;cohort;Computer Analysis;Consumption;craving;Crossover Design;Cues;Data;design;Diagnosis;Dose;Educational Status;Etiology;experience;FDA approved;Fellowship;Functional disorder;Future;General Population;Goals;Heterogeneity;Individual;Individual Differences;individual response;individual variation;Insula of Reil;Intervention;K-Series Research Career Programs;Lead;Left;Life Expectancy;Link;Mediating;Mentors;Mentorship;mortality;neuroimaging;neuroregulation;Neurosciences;Nicotine;nicotine craving;Nicotine Dependence;nicotine treatment;nicotine use;Pathologic;Pathology;Pathway Analysis;Pathway interactions;patient oriented;Pattern;Persons;pharmacologic;Pharmacology;Population;Prefrontal Cortex;Preparation;Prevalence;programs;Psychiatrist;Psychoses;Psychotic Disorders;relapse prediction;repetitive transcranial magnetic stimulation;Research;response;Schizophrenia;Severities;Site;skills;Smoker;smoking cessation;Smoking Cessation Intervention;substance use;Substance Use Disorder;Testing;Tobacco use;Training;ward

PROJECT_TITLE: Network-Targeted Neuromodulation for Nicotine Dependence in Schizophrenia

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Gene Therapy;Genetics;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Chimeric antigen receptor T-cells (CART) have revolutionized the treatment of relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL) and improved survival rates in this population. However, CART can cause severe immune dysregulation disorders that we do not fully understand. This proposal will define the mechanistic biology of immune dysregulation disorders occurring post CART and test potential novel therapies for the treatment of these disorders.

PI_NAMEs: DIORIO, CAROLINE  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Achyrocline;Adrenal Cortex Hormones;Advisory Committees;Animals;Area;Automobile Driving;Award;B-Cell Acute Lymphoblastic Leukemia;base;Biology;cancer immunotherapy;cancer therapy;career;CD19 gene;Cells;Cellular immunotherapy;Cerebral Edema;Cessation of life;chimeric antigen receptor T cells;Clinical Immunology;clinical translation;Clinical Trials;Complement;Complement Activation;Complement component C5;Complex;Confusion;cytokine;cytokine release syndrome;Data;Data Set;Development;Disease;effective therapy;Environment;experience;Fever;Foundations;Functional disorder;Funding;Future;Genetic Transcription;Goals;Health;Hemophagocytic Lymphohistiocytoses;IL18 gene;Immune;immune effector cell-associated neurotoxicity syndrome;Immune system;Immunologic Factors;Immunologist;Immunotherapy;improved;In Vitro;in vivo;Incubated;Individual;Inflammasome;Infusion procedures;Innate Immune System;insight;Interferon Type II;Interleukin-6;Life;Malignant Neoplasms;Membrane Proteins;Mentors;Mentorship;Modeling;monocyte;mouse model;neuroinflammation;novel;novel therapeutics;Patients;Pediatric Hospitals;Pediatric Oncologist;Pennsylvania;Philadelphia;Physicians;Population;prevent;Production;prognostic;programs;Proteins;Proteomics;Publishing;Refractory;Relapse;repository;Research;Research Project Grants;Role;Sampling;Scientist;Seizures;Serum;Severities;Shock;single-cell RNA sequencing;skills;standard of care;success;Survival Rate;Symptoms;T-Lymphocyte;Techniques;Testing;therapeutic target;Toxic effect;Training;Transcriptional Activation;transcriptomics;Translating;Translations;Universities;Work

PROJECT_TITLE: Calming the Cytokine Storm: Unraveling the Biology of CRS and ICANS

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: DC

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative Human society is supported by neurobiological specializations that enable advanced social cognition and important behavioral phenomena like cooperation and communication. Nevertheless, a mechanistic description of social cognitive networks remains a distant ambition of neuroscience research, despite the potential to enhance public health and support the diagnosis and treatment of nervous system dysfunction. The proposed career development study aims to address this key research gap by investigating the nervous system of a highly social model organism with a simple and tractable brain, the clonal raider ant.

PI_NAMEs: FRANK, DOMINIC DAVID (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Address;Adult;Affect;Anatomy;Animals;Ants;Area;autism spectrum disorder;axon guidance;Behavioral;Biomedical Research;Brain;Brain region;Calcium;Calcium Oscillations;Calcium Signaling;career development;Chemicals;Cognitive;Communication;Complex;Data;Dedications;Development;Diagnosis;Distant;Drosophila genus;Drosophila melanogaster;emerging adult;Evolution;Exocrine Glands;experimental study;Fluorescence Microscopy;fly;Functional disorder;Genetic;Human;Image;Immunohistochemistry;in vivo;Insecta;Intervention;Invertebrates;Lobe;Logic;Mammals;Membrane;model organism;Modeling;Modernization;Molecular;mutant;Nervous System;nervous system development;Neurobiology;neurodevelopment;Neurodevelopmental Disorder;neurogenetics;Neurons;Neuropil;Neurosciences Research;novel;novel diagnostics;olfactory bulb;olfactory bulb glomeruli;Olfactory Pathways;olfactory sensory neurons;optogenetics;overexpression;Pathogenesis;pharmacologic;Phenotype;Pheromone;Potassium Channel;Process;Public Health;Pupa;Research;sensory system;SLC25A4 gene;social;social cognition;social communication impairment;social model;Societies;Structure;synaptogenesis;Testing;Time;tool;Transgenic Organisms;two photon microscopy;two-photon;Work

PROJECT_TITLE: Neurodevelopmental adaptations prime olfactory circuits for complex pheromonal communication in the clonal raider ant.

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Palliative Care;Racial and Ethnic Minority Health Research

ORG_CITY: KANSAS CITY

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE Latino families with Alzheimer’s disease and other dementias (ADRD) experience substantial disparities in mental health outcomes and access to caregiver support. This project will address these disparities by testing the efficacy of CuidaTEXT, a text message intervention to support Latino caregivers of people with ADRD.

PI_NAMEs: PERALES PUCHALT, JAIME  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Address;Adult;Affect;Aftercare;Alzheimer's Disease;Alzheimer's disease related dementia;Area;arm;behavior change;Behavioral Model;Behavioral Symptoms;bilingualism;Caregiver support;Caregivers;caregiving;Cellular Phone;Clinical;Control Groups;coping;Data;Dementia;depressive symptoms;design;Disparity;Distress;Education;efficacy evaluation;efficacy testing;Emotional;Ethnic Population;Exclusion;experience;Family;Family Caregiver;family caregiving;Feasibility Studies;Foundations;Immigration;implementation cost;improved;Individual;Intervention;Language;Latino;Latino Population;Linguistics;Managed Care;Mediating;Mediation;Mental Depression;Mental Health;Minority Groups;Modeling;National Institute on Aging;new technology;Outcome;Persons;Policies;Population;primary outcome;Process;racial population;Randomized;randomized, clinical trials;Readiness;Research;Resources;satisfaction;Science;secondary outcome;Self Care;Social support;Spanish;Spanish/English;Stress;stressor;symptom management;tailored messaging;Technology;Testing;Text;Text Messaging;text messaging intervention;therapy development;Time;Transportation;treatment effect;Uninsured;United States National Institutes of Health;usability;Waiting Lists;web site;Work

PROJECT_TITLE: Testing the effects of a text message caregiver support intervention for Latinos

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-S (O1)]


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE Exposure to anti-cancer drugs at work is dangerous to the health of nurses who handle these drugs. This research focuses on developing and testing an intervention targeted to increase nurses’ adherence to safe practice guidelines when handling anti-cancer drugs. This research is relevant to public health, because it will help prevent the exposure to anti-cancer drugs for nurses and protect them from the health complications that could result from this exposure.

PI_NAMEs: ABU-ALHAIJA, DANIA  (contact)

PROGRAM_OFFICER_NAME: GARRETT, BRIDGETTE E

PROJECT_TITLE: Promoting Adherence to Chemotherapy Handling Guidelines Among Oncology Nurses

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

PHR: Loneliness and social isolation are strongly linked to indices of healthy brain aging, cognitive decline, and dementia. Reducing loneliness/isolation is a potent strategy to promote healthy brain aging and prevent cognitive decline and Alzheimer’s Disease and Related Dementias (ADRD). This application forms the basis for an evolving program of research on the translational science of loneliness/isolation and its role in brain aging, with the long-term objective to identify and disseminate evidence-based interventions for loneliness/isolation in later life, including determining the mechanisms that account for improved health outcomes—mental health, cognitive health, and physical health outcomes.

PI_NAMEs: VAN ORDEN, KIMBERLY ALLISON (contact)

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: Acceleration;Accidental Injury;Address;Affective;aging brain;alcohol misuse;Alzheimer's Disease;Alzheimer's disease related dementia;Animal Model;Animals;Attenuated;Behavior;Behavior Therapy;Behavioral;Behavioral Mechanisms;Brain;Buffers;career;caregiving research;Cause of Death;Chronic;Clinical;clinical trial analysis;Clinical Trials;Cognition;Cognitive;Cognitive aging;cognitive function;Data;Data Set;Dementia;design;Development;Diabetes Mellitus;Discipline;Distress;Drops;effective intervention;evidence base;Evidence based intervention;experience;experimental study;Feeling;follow-up;Fostering;Funding;Health;Healthcare;healthy aging;Heart Diseases;Heterogeneity;Human;Impaired cognition;improved;indexing;Individual;Influenza;interdisciplinary collaboration;Intervention;Intervention Trial;Interview;Kidney Diseases;Laboratories;laboratory experience;late life;Link;Literature;Loneliness;Malignant Neoplasms;Mediating;Mental Health;Mentors;Meta-Analysis;Mid-Career Clinical Scientist Award (K24);Modeling;mortality;Neurosciences;non-compliance;older adult;Outcome;Participant;patient oriented research;physical conditioning;physical inactivity;prevent;Preventive Medicine;prognostic indicator;programs;Publishing;Quality of life;Research;Research Project Grants;Respiratory Disease;response;Risk;Risk Factors;Rodent;Role;Safety;Science;Scientist;secondary analysis;Security;Smoking;social;Social Interaction;social interventions;Social isolation;Socialization;Stress;Stroke;Structure;study characteristics;Suicide;Testing;Time;Training;Translational Research;Unhealthy Diet;vaccine response

PROJECT_TITLE: Brain and Behavioral Mechanisms Linking Loneliness and Social Isolation with Accelerated Cognitive Aging and Alzheimer's Disease and Related Dementias

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Congenital Structural Anomalies;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Primary Immunodeficiencies;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Individuals who possess a genetic deletion of part of chromosome 22 have smaller brains and are predisposed to multiple neurodevelopmental disorders including intellectual disability and autism. The goal of this work is to study how mitochondrial proteins encoded by genes within the deleted region function during neurodevelopment to establish brain structure and function. This research will define mechanisms underlying neurodevelopmental disorders and provide new avenues for therapeutic intervention.

PI_NAMEs: CAMPBELL, PHILIP  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: 22q11.2;Advisory Committees;Affect;autism spectrum disorder;Behavior;Behavioral;behavioral phenotyping;Brain;brain size;brain volume;career;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;Cell Line;cell type;Cells;Chromosome 22;Chromosomes;Code;Communities;Complement;CRISPR/Cas technology;Data;Defect;design;Development;DiGeorge Syndrome;experimental study;Foundations;Functional disorder;gene complementation;Gene Deletion;Genes;Genetic;Genetic Transcription;genome editing;Goals;Heterozygote;Homo;human induced pluripotent stem cells;human model;Image;Immunohistochemistry;in vivo;in vivo imaging;Individual;induced pluripotent stem cell;innovation;insight;Intellectual functioning disability;Lead;Link;Live Birth;Mentorship;Microcephaly;microdeletion;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modeling;Monitor;mouse model;mutant;Mutate;National Institute of Neurological Disorders and Stroke;neural;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;Neurons;Neurosphere;next generation sequencing;Optics;Organoids;Orthologous Gene;Oxidation-Reduction;Pathogenesis;Pathologic;Pathway interactions;Patients;Pennsylvania;Phenotype;Physicians;Play;Population;Positioning Attribute;postmitotic;Process;progenitor;programs;Proliferating;Proliferation Marker;Proteins;Psychiatrist;Regulation;Reporter Genes;Reporting;Research;Resolution;Resources;Role;Running;Scientist;screening;Series;Signal Transduction;single-cell RNA sequencing;small molecule;stem;stem cell model;stem cell population;stem cell proliferation;stem cells;Strategic Planning;Structure;Study models;Syndrome;System;Testing;Therapeutic;Therapeutic Intervention;Training;Transgenic Organisms;Universities;Work;Zebrafish

PROJECT_TITLE: Mitochondrial mechanisms underlying neural stem and progenitor cell proliferation deficits in 22q11.2 deletion syndrome

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]