NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetic Testing;Genetics;Prevention;Rare Diseases;Women's Health Research

PHR: NARRATIVE Since approximately 2010, the scale of clinical cancer predisposition genetic testing has increased dramatically; however, the ability to evaluate and classify DNA sequence variation reported from that testing has not kept up. The difference between the rate of testing and the rate of sequence variant classification has resulted in a rapidly increasing number of sequence Variants of Uncertain Significance (VUS), causing problems in patient counseling and management. Completion of the studies proposed here will improve rigor in the system used for evaluation of VUS in cancer susceptibility genes, enabling higher throughput VUS evaluation and improving confidence in the resulting classifications.

PI_NAMEs: TAVTIGIAN, SEAN VAHRAM (contact)

PROGRAM_OFFICER_NAME: ROTUNNO, MELISSA

PROJECT_TERMS: Adopted;Agreement;Alleles;American;Area;Attention;Back;Bayesian Modeling;Benchmarking;Benign;Biological Assay;brca gene;BRCA1 gene;BRCA2 gene;Breast;Calibration;cancer predisposition;cancer risk;Cancer-Predisposing Gene;Categories;Classification;Clinical;Clinical Management;clinically actionable;Colorectal Cancer;Communities;Computer Analysis;computerized tools;Counseling;Country;Data;Data Adjustments;Decision Trees;Dependence;Disinhibition;DNA Sequence;Early Diagnosis;Elements;Evaluation;Expert Opinion;Family Cancer History;family management;Gene Frequency;Genes;Genetic;Genetic Predisposition Testing;genetic variant;Germ Lines;Group Meetings;Guidelines;Hereditary Nonpolyposis Colorectal Neoplasms;Human;improved;Individual;insertion/deletion mutation;insight;Intercept;International Agency for Research on Cancer;Legal patent;Li-Fraumeni Syndrome;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Massive Parallel Sequencing;Measurement;Measures;Medical;Medical Genetics;medical schools;meetings;Melanoma;Mendelian disorder;Messenger RNA;Methods;Mutation;Oncogenes;Operative Surgical Procedures;Output;PALB2 gene;Paper;parallel computer;Parents;Pathogenicity;Patient observation;Patients;prevent;Probability;protein function;Protein Truncation;Publishing;Reporting;RNA Splicing;Role;Route;segregation;Sequence Analysis;Susceptibility Gene;System;Testing;Variant;variant of unknown significance;Veins;Weight;working group

PROJECT_TITLE: Upgrading rigor and efficiency of germline cancer gene variant classification for the 2020s

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Dietary Supplements;Lung;Neonatal Respiratory Distress;Nutrition;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

ORG_CITY: LUMBERVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: ADVENT THERAPEUTICS, INC.

ORG_STATE: PA

PHR: The consequences of inadequately treated vitamin A deficiency (VAD) in premature neonates includes increased risk for bronchopulmonary dysplasia (BPD), which is associated with poor clinical outcomes in these fragile patients and requires costly long-term care. Advent Therapeutics is developing an aerosol formulation of its proprietary optimized, water miscible vitamin A palmitate (vitA) for non-invasive delivery of the drug to preterm infants, enabling dosing via inhalation and thus obviating the need for intramuscular (IM) injection; direct delivery to the lung (a direct-to-target-organ treatment for BPD) should increase effectiveness, while simultaneously providing systemic vitamin A availability, important for treating VAD and its related complications (not only BPD, but also retinopathy of prematurity (ROP) and sepsis). Dosing vitA by inhalation should overcome current hurdles limiting vitamin A supplementation use in the NICU, enabling much higher vitamin A utilization, with potential to decrease risk and cost of BPD in preterm infants.

PI_NAMEs: GELFAND, CRAIG  (contact);REHAN, VIRENDER K

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: absorption;Acute;Address;Adult;aerosolized;Aerosols;Age;All-Trans-Retinol;animal data;Animal Model;Animals;authority;Award;Biological Assay;Biological Markers;Biotechnology;Bronchopulmonary Dysplasia;Canis familiaris;chemical stability;Chronic Phase;Clinic;clinic ready;Clinical;Clinical Research;Collaborations;commercialization;Complication;Confidential Information;cost;Data;Data Set;Development;Dose;Drug Delivery Systems;drug development;drug efficacy;drug testing;Effectiveness;Engineering;Enteral;evaluation/testing;FDA approved;first-in-human;Formulation;Funding;Gene Expression Regulation;Gene Proteins;Generations;Goals;Guidelines;Human;Hyperoxia;in vivo;Inhalation;Injections;innovation;interest;Intramuscular;Intramuscular Injections;lamb model;Life;liver injury;Long-Term Care;long-term sequelae;Lung;lung development;lung injury;lung maturation;manufacture;Measures;Medical;Medical center;Medicine;meetings;Modeling;Morphology;National Heart, Lung, and Blood Institute;Nebulizer;Neonatal;Neonatal lung;neonatal sepsis;neonate;Newborn Infant;novel;novel strategies;Oral;Organ;Orphan;Oryctolagus cuniculus;Outcome;oxidative damage;Pathway interactions;patient population;Patients;Pharmaceutical Economics;Pharmaceutical Preparations;Phase;Phospholipids;Population;postnatal;pre-clinical;premature;Premature Infant;preservation;preterm newborn;prevent;Prevention;Process;product development;Production;Productivity;Program Development;protein expression;Proteins;Publications;Publishing;pulmonary function;Pulmonary function tests;Pulmonary Inflammation;Rattus;receptor;reconstitution;Regimen;Research;research clinical testing;Retinopathy of Prematurity;retinyl palmitate;Risk;Rodent;Safety;scale up;Science;Secure;Sepsis;Serum;Severities;side effect;Small Business Innovation Research Grant;Structure of parenchyma of lung;success;Supplementation;surfactant;Testing;Therapeutic;Toxic effect;Toxicology;Up-Regulation;Validation;Vitamin A;Vitamin A Deficiency;Water;Work

PROJECT_TITLE: Aerosolized Vitamin A: Developing a Prevention for Hyperoxic Lung Injury and Bronchopulmonary Dysplasia, with Focus on Neonatal Lung Maturation


ADMINISTERING_IC: VA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: SEATTLE

ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

ORG_STATE: WA

PHR: Relevance Prostate cancer is the leading cause of cancer related death in veterans. Although significant progress has been made in treatment, “exceptional responses” are rare and there is currently no way to personalize care for men with this disease. This study will test the effectiveness of carboplatin, a drug with early evidence for exceptional responses and lower toxicity, against the standard of care chemotherapy drug in veterans with specific mutations in their cancer which would predict for effectiveness. If successful, this study could provide a means of predicting which veterans could benefit from more effective and less toxic therapy for metastatic, resistant prostate cancer.

PI_NAMEs: MONTGOMERY, BRUCE  (contact)

PROJECT_TERMS: abiraterone;Address;advanced prostate cancer;Affect;androgen independent prostate cancer;Biological Markers;biomarker performance;bone imaging;BRCA deficient;brca gene;BRCA1 gene;BRCA2 gene;Cancer Etiology;Carboplatin;Cessation of life;chemotherapy;Combined Modality Therapy;comparative efficacy;cost effectiveness;Data;Decision Making;Defect;design;Disease;Disease Progression;DNA;DNA Damage;DNA Repair;DNA Repair Disorder;DNA Repair Pathway;docetaxel;Effectiveness;effectiveness study;effectiveness testing;efficacy evaluation;enzalutamide;FDA approved;Future;Genes;Histology;homologous recombination;homologous recombination deficiency;Lesion;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;Measurable Disease;men;Metastatic Prostate Cancer;Molecular;Mutation;objective response rate;Older Population;Outcome;PALB2 gene;Pathway interactions;Patient Agents;Patients;personalized care;Pharmaceutical Preparations;Phase;phase 2 study;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;potential biomarker;predicting response;predictive marker;primary endpoint;Prior Therapy;Progression-Free Survivals;Randomized;Regimen;Reporting;Resistance;response;response biomarker;Screening for Prostate Cancer;secondary endpoint;standard of care;targeted agent;Testing;Therapeutic;Time;time interval;Toxic effect;Treatment-related toxicity;tumor;Veterans;Vulnerable Populations;Work

PROJECT_TITLE: Carboplatin or Olaparib for BRcA deficient prostate cancer (COBRA)


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Genetics;Human Genome;Rheumatoid Arthritis

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative: T cells help stimulate B cells to produce autoantibodies in many autoimmune diseases, yet the signals that regulate whether and how T cells can stimulate B cell responses remain unclear. In this project, we study the role that a specific transcription factor, the aryl hydrocarbon receptor, plays in regulating the generation of B cell-helper T cells. This work may help understand how the aryl hydrocarbon receptor can be modulated to dampen autoimmue T cell-B cell interactions.

PI_NAMEs: RAO, DEEPAK ANGARA (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Affect;Agonist;American;antagonist;Architecture;Arthritis;Aryl Hydrocarbon Receptor;Autoantibodies;Autoimmune Diseases;Autoimmune Hepatitis;Autoimmunity;B cell differentiation;B-Lymphocytes;BCL6 gene;Biological Assay;BLR1 gene;burden of illness;cancer infiltrating T cells;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Celiac Disease;Cell Aggregation;Cell Communication;Cell Differentiation process;cell motility;Cell Physiology;Cells;Chemotactic Factors;ChIP-seq;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;CXCL13 gene;cytokine;Data;Degenerative polyarthritis;Development;Disease;effector T cell;Epigenetic Process;epigenetic regulation;exhaust;exhaustion;Fibroblasts;Frequencies;Gene Targeting;Generations;Genes;Genetic;Genetic Transcription;Genomics;Goals;Helper-Inducer T-Lymphocyte;Human;Immune System Diseases;Infiltration;Infrastructure;Insulin-Dependent Diabetes Mellitus;interleukin-21;Interruption;Joints;Ligands;Lupus;Lymphoid Follicle;Measures;Mediating;Mediator;Methods;Modification;Molecular;monocyte;novel;Pathologic;Patients;Pattern;Peripheral;pharmacologic;Phenotype;Plasmablast;Play;Population;Production;Psoriatic Arthritis;Receptor Activation;Receptor Inhibition;recruit;Regulation;Reporter;Reporting;repository;response;Rheumatoid Arthritis;Role;Sampling;secondary lymphoid organ;seropositive;Serum;Signal Transduction;single-cell RNA sequencing;Source;Structure of germinal center of lymph node;Surface;Synovial Fluid;Synovial Membrane;Systemic Scleroderma;T cell differentiation;T-Lymphocyte;T-Lymphocyte Subsets;Techniques;Testing;Therapeutic;Tissues;Tonsil;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Work

PROJECT_TITLE: Regulation of T helper cell functions by aryl hydrocarbon receptor

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: IOWA CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Disease in blood vessel leads to either reduction or stoppage of blood supply to the organ leading to organ malfunction or even death. The common examples are heart attack due to myocardial ischemia and paralysis due to stroke. Using experimental animal models we will investigate the mechanism involved in the development of atherosclerosis (fat deposition in blood vessels) and will identify ways to protect the vascular function and health.

PI_NAMEs: KUMAR, SANTOSH  (contact)

PROGRAM_OFFICER_NAME: PLAYFORD, MARTIN P

PROJECT_TERMS: Acceleration;Affect;Animal Experimentation;Arterial Fatty Streak;Atherosclerosis;Automobile Driving;Biological Assay;Biological Availability;Blood Vessels;Breeding;Cells;Cessation of life;Data;Deposition;Development;Disease;DNA Modification Process;Endothelial Cells;endothelial dysfunction;Endothelium;Experimental Animal Model;Fatty acid glycerol esters;Health;Heat-Shock Proteins 70;Hyperlipidemia;ICAM1 gene;Impairment;In Vitro;inflammatory marker;Knock-in Mouse;Knock-out;Knowledge;Low-Density Lipoproteins;Lysine;Measures;Mitochondria;Molecular;Mus;Myocardial Infarction;Myocardial Ischemia;Nitric Oxide;novel;novel therapeutic intervention;Organ;Outcome;overexpression;Oxidation-Reduction;Oxidative Stress;p66(ShcA) protein;Paralysed;Phosphorylation;Physiological;Post-Translational Protein Processing;Production;Property;Proteins;Reactive Oxygen Species;Reporting;Risk Factors;Role;sensor;Stroke;SUMO1 gene;Sumoylation Pathway;Testing;tool;transgene expression;Transgenic Mice;Ubiquitin;Vascular blood supply;Vascular Diseases;vascular endothelial dysfunction;Vascular Endothelium;vascular inflammation;Vasodilation

PROJECT_TITLE: SUMO2-p66shc axis in vascular endothelial dysfunction and atherosclerosis

STUDY_SECTION: AICS

STUDY_SECTION_NAME: Atherosclerosis and Inflammation of the Cardiovascular System Study Section[AICS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Immunotherapy;Infectious Diseases;Lung;Microbiome;Pneumonia;Pneumonia and Influenza

ORG_CITY: Aurora

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative This proposal addresses the significant burden of respiratory disease by investigating how a prevalent airway commensal, Prevotella melaninogenica, contributes to lung health. A protective phenotype identified for P. melaninogenica in humans is recapitulated using an animal model to investigate the specific bacterial factors, host cells, and innate immune receptors required to promote clearance of Streptococcus pneumoniae, the dominant cause of bacterial pneumonia, from the lung. The goal of these studies is to define the mechanistic basis for such clearance, which is the next step toward designing new probiotic-based immunotherapeutic strategies to enhance protection against bacterial pneumonia.

PI_NAMEs: CLARK, SARAH E (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Address;Alveolar Macrophages;Animal Model;antagonist;Anti-Inflammatory Agents;Antibiotic Therapy;Bacteria;Bacterial Pneumonia;Cells;Cellular Infiltration;cellular targeting;Clinical;clinically relevant;co-infection;commensal bacteria;community acquired pneumonia;cytokine;Data;defined contribution;design;Development;Digestion;Exposure to;Goals;host microbiome;Hour;Human;Immune;Immunologic Receptors;Immunotherapeutic agent;Immunotherapy;improved;Individual;Infection;infection risk;Inflammation;Inflammatory;Inflammatory Response;Injury;Innate Immune Response;Integration Host Factors;Interleukin-10;Intervention;Invaded;Kinetics;Knowledge;Ligands;Lipopolysaccharides;Lipoproteins;Lung;lung health;Lung infections;lung microbiome;Mediating;member;microbial;microbiota;Molecular;mouse model;Mus;Myeloid Cell Activation;Myeloid Cells;neutrophil;Neutrophil Activation;Neutrophil Infiltration;next generation sequencing;novel;opportunistic pathogen;Outcome;overexpression;Pathology;Pathway interactions;Persons;Phenotype;Pneumococcal Pneumonia;Pneumonia;Predisposition;prevent;Prevotella;Prevotella melaninogenica;Probiotics;Production;protective effect;Pulmonary Pathology;receptor;recruit;Regulation;Resolution;respiratory;Respiratory Disease;respiratory microbiome;restraint;Role;Signal Transduction;single-cell RNA sequencing;Source;Streptococcus pneumoniae;synergism;TLR2 gene;TLR4 gene;TNF gene;TNFRSF1A gene;Translations;Vulnerable Populations;Work

PROJECT_TITLE: Airway Prevotella enhance innate immune-mediated protection against lung infection

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Prostate cancer remains the second leading cause of deaths due to cancer in North American men. Defining the communication pathways that operate within prostate cancer cells, which is to say, how proteins talk to each other, reveals vulnerabilities that can be exploited therapeutically. We discovered a communication pathway in prostate cancer cells, and propose to determine how it works, and if pathway inhibition with a new drug (in clinical trials) can kill prostate cancer cells.

PI_NAMEs: PASCHAL, BRYCE  (contact)

PROGRAM_OFFICER_NAME: LIU, ZHIHUI

PROJECT_TERMS: Adenosine Diphosphate Ribose;ADP ribosylation;Agonist;American;Amino Acids;androgen independent prostate cancer;Androgen Receptor;androgen sensitive;Androgens;Animal Model;Binding;Biochemical;Bioinformatics;Biological;Biological Assay;Cause of Death;Cell Culture Techniques;Cell Line;Chemistry;Clinical;Clinical Trials;Communication;Complex;Cysteine;Denmark;Dependence;Ensure;experimental study;Finland;Funding;Gene Expression;Genes;Genetic Transcription;Genomics;Growth;Histones;inhibitor;International;knowledge base;Ligase;Malignant neoplasm of prostate;Malignant Neoplasms;Mass Spectrum Analysis;Massachusetts;Mediating;men;Modeling;Modification;Molecular;Molecular Conformation;mutant;N-terminal;Neoplasm Metastasis;Netherlands;new therapeutic target;non-genomic;novel;novel therapeutics;Outcome;PARP inhibition;PARP9 gene;Pathway interactions;Peptide Synthesis;permissiveness;Phenotype;Poly(ADP-ribose) Polymerase Inhibitor;Positioning Attribute;Pre-Clinical Model;prevent;Prostate;prostate cancer cell;prostate cancer model;prostate carcinogenesis;Prostatic Neoplasms;Proteins;Proteome;Reaction;Reader;Reading;Regulation;Scientist;Signal Transduction;Site;Specific qualifier value;structural biology;Structure;success;synthetic peptide;Testing;Therapeutic;tool;transcription factor;Transcriptional Regulation;Transducers;tumor growth;tumorigenesis;tumorigenic;Virginia;Work;Writing;Xenograft Model

PROJECT_TITLE: Parp Function in Prostate Cancer

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: MORGANTOWN

ORG_DEPT: PSYCHOLOGY

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: Diversity among scientists increases our ability to solve the problems facing society. The proposed educational program seeks to increase the diversity of the workforce in aging and health disparities as a means to reduce such health disparities. Focusing on students who are typically underrepresented in the MSTEM fields, the Appalachia Gerontology Experiences (AGE) Scholars Program would provide content knowledge and hands-on experiences in aging and health disparities research.

PI_NAMEs: PATRICK, JULIE MARIE (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Address;Adult;Aging;aging related;American;Appalachian Region;Area;Communities;Complex;cultural competence;Death Rate;Development;Discipline;Education;Environment;experience;Faculty;geographic barrier;Gerontology;Goals;Group Structure;hands on research;Health;Health behavior;Health Disparities Research;health disparity;health literacy;Health Professional;healthy aging;Home;Income;interest;Knowledge;Medical;Mentors;Morbidity - disease rate;Poverty;programs;Psychiatric Social Work;Reduce health disparities;Research;Research Methodology;Research Personnel;Resources;Rest;Rural;rural area;rural residence;scaffold;Scholars Program;Science;scientific literacy;Scientist;Societies;Structure;Students;Translational Research;Unemployment;United States;West Virginia;Work;Writing

PROJECT_TITLE: Appalachian Gerontology Experiences - Advancing Diversity in Aging Research


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Microbiome

ORG_CITY: CHAPEL HILL

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will identify novel factors that regulate Paneth cells, a key group of cells in the intestine that support the antimicrobial barrier of the gut. Importantly, abnormal Paneth cell function has been linked to several gastrointestinal disorders in which this antimicrobial barrier is impaired (i.e. Crohn’s disease, necrotizing enterocolitis, and graft-versus-host disease). Identifying factors that enhance the function of these cells has the potential to lead to novel therapies for a spectrum of gastrointestinal disease, directly supporting the stated mission of the NIDDK.

PI_NAMEs: GULATI, AJAY S (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Anti-Inflammatory Agents;anti-microbial peptide;antimicrobial;Bacteria;Cell Count;Cell Physiology;Cells;Cellular biology;Censuses;Clinical;clinically relevant;Coculture Techniques;Crohn's disease;Data;design;Development;Disease;dysbiosis;Ecology;Elements;enhancing factor;enteric dysbiosis;enteric pathogen;Enteritis;Epithelial Cells;experimental study;extracellular;Functional disorder;Future;Gastrointestinal Diseases;Germ-Free;Goals;graft vs host disease;gut microbiota;Homeostasis;Housing;Human;human disease;Impairment;in vivo;Individual;Inflammation;Inflammatory;innovation;insight;interleukin-22;Intestinal Diseases;intestinal epithelium;Intestines;Knowledge;Lamina Propria;Ligands;Link;Measures;Mediating;Messenger RNA;Microbe;microbial;microbiota;Mission;Modeling;Morbidity - disease rate;mortality risk;mouse model;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Necrotizing Enterocolitis;neutralizing antibody;new therapeutic target;Non-Steroidal Anti-Inflammatory Agents;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Outcome;Paneth Cells;Pathogenesis;Patients;Play;Population;prevent;Probiotics;Production;Proteins;Public Health;Publishing;Regulation;Reporter;Reporting;Research;response;Role;Secretory Cell;Side;Signal Transduction;single-cell RNA sequencing;Small Intestines;Submucosa;surgical risk;Testing;Therapeutic;Therapeutic Intervention;therapy development;Thromboplastin;Tissues;transcriptome sequencing;treatment strategy;Work

PROJECT_TITLE: Mechanisms of Gut Microbiota-Driven Paneth Cell Regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-D(90)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Hematology;Kidney Disease;Lung;Physical Injury - Accidents and Adverse Effects;Rare Diseases;Sickle Cell Disease

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Sickle Cell Trait (SCT) - which affects 1 out of 13 African Americans - is associated with high risk of sudden death and serious complications under stressful condition, which makes people with SCT vulnerable in cases of chlorine industrial accidents that happen frequently (every 2-3 days in the United States). Therefore, this study will test if humanized SCT mice are more vulnerable to death and serious organ injury following chlorine inhalation and if post-exposure haptoglobin injection negates the effect of chlorine exposure.

PI_NAMEs: ALISHLASH, AMMAR  (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Accidents;Accounting;Acute;Acute Renal Failure with Renal Papillary Necrosis;Acute-Phase Proteins;Adverse effects;Affect;African American population;Altitude;Attenuated;Binding;Carrier State;Cessation of life;Child;Chlorine;Chronic;comparison control;Data;Death Rate;Development;Disease;Dose;Elderly woman;Erythrocytes;Europe;Exercise;Exhibits;Exposure to;Haptoglobins;Heart;Heart Injuries;Heme;Hemoglobin;hemoglobin AA;Hemolysis;Hemopexin;high risk;Hour;Hypoxia;improved;improved outcome;Individual;Industrial Accidents;Inhalant dose form;Inhalation;Injections;Injury;Injury to Kidney;innovation;intraperitoneal;Japan;Kidney;Long-Term Effects;Lung;lung injury;mass casualty;Mediating;Medical Device;mortality;mortality risk;multiorgan injury;Multiple Organ Failure;Mus;Myoglobin;Organ;organ injury;Persons;Population;pre-clinical;Predisposition;Pregnant Women;Public Health;Quality of life;Randomized;Recommendation;Reduce health disparities;Reporting;Research;Rhabdomyolysis;Risk;Risk Factors;Sickle Cell Anemia;Sickle Cell Trait;Strenuous Exercise;stressor;Structure;Sudden Death;System;targeted treatment;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;Time;Tissues;Toxic effect;toxicant;Toxicant exposure;Transfusion;United States;Vulnerable Populations;Work

PROJECT_TITLE: Sickle Cell Trait Mice are More Susceptible to Chlorine Exposure and Haptoglobin Improves the Outcomes


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Services;Mental Health;Mental Illness;Opioid Misuse and Addiction;Opioids;Patient Safety;Social Determinants of Health;Substance Misuse

ORG_CITY: LOS ANGELES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Poor adherence to medications for treating opioid use disorders threatens to limit the public health benefit of improving access to these life-saving medications. Co-morbidities such as chronic pain and depression often co- occur in patients with opioid use disorders and their families, which may play an important role in medication adherence and patient outcomes in real-world clinical practice. The purpose of this project is to train the recipient to generate new knowledge about the role of the household in adherence to buprenorphine for the treatment of opioid use disorders and associated serious adverse events, with the goal of helping to achieve optimal public health outcomes with medications for opioid use disorders and reduce costs.

PI_NAMEs: SEAMANS, MARISSA J (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: addiction;Address;Adherence;Adverse event;adverse outcome;alcohol use disorder;American;Anxiety;beneficiary;Benzodiazepines;Buprenorphine;buprenorphine treatment;career;Child;chronic depression;chronic pain;Clinical;Clinical assessments;clinical care;clinical decision support;clinical diagnosis;clinical practice;clinical predictive model;clinically relevant;comorbidity;contextual factors;cost;Data;Data Analyses;data warehouse;Databases;design;Development;drug misuse;Drug Prescriptions;economic evaluation;Educational workshop;Emergency department visit;Environmental Risk Factor;Family;Family member;Foundations;Genetic;Goals;Health;Health Benefit;Health Care Costs;health care service utilization;Health Insurance;Health Insurance Reimbursement;health plan;Health Services Research;Health Status;Healthcare;high risk;Hospitalization;Household;Improve Access;improved;Incidence;indexing;Individual;innovation;insight;Insurance Carriers;insurance claims;Intervention;Knowledge;Learning;Life;medication compliance;medication for opioid use disorder;Medicine;meetings;Mental Depression;Mental disorders;Mental Health;Mentored Research Scientist Development Award;Mentors;Mentorship;Methods;Muscle relaxants;Opioid;opioid overdose;opioid use;opioid use disorder;Outcome;Overdose;Pain;Parents;Patient-Focused Outcomes;Patients;Personal Satisfaction;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;Pharmacotherapy;Play;Policies;predictive modeling;Privatization;Psychiatry;psychosocial;Public Health;Publishing;Recording of previous events;Research;Research Personnel;responsible research conduct;Risk;Risk Factors;Role;sedative;Serious Adverse Event;Siblings;skills;Spouses;Stimulant;Substance Use Disorder;substance use treatment;support tools;Time;Training;treatment adherence;Uninsured Medical Expense

PROJECT_TITLE: Real-world complexities in opioid use disorder treatment: understanding family comorbidity, high-risk medication use, and costs related to treatment adherence and health outcomes

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Nutrition

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative  Excessive accumulation of lipid droplets (LDs) leads to obesity and many metabolic diseases and dynamics of lipid droplets (LDs) on endoplasmic reticulum are tightly regulated by enzymatic proteins. This study will investigate the novel function of an ER targeting protein named Dynamin-Related Protein 1 (DRP1) on LD budding. Insights into the key role of DRP1 shed new light on potential strategies to treat diseases associated with abnormal lipid accumulation.

PI_NAMEs: SUN, KAI  (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Ablation;Adipocytes;Adrenergic Agents;Adverse effects;Affect;Apoptosis;Autophagocytosis;Binding;Biogenesis;BSCL2 gene;Cell Physiology;cell type;Cells;constriction;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cytosol;Data;Disease;Dissociation;Dynamin;Endoplasmic Reticulum;endoplasmic reticulum stress;Energy Intake;Energy Metabolism;Event;experimental study;Goals;Guanosine Triphosphate Phosphohydrolases;Homeostasis;Impairment;In Vitro;in vivo;Inflammation;insight;Isoproterenol;Knowledge;Link;Lipid Binding;lipid disorder;lipid metabolism;Lipids;Location;loss of function;Mass Spectrum Analysis;Measures;Mediating;Membrane Proteins;membrane reconstitution;Metabolic;Metabolic Diseases;Mitochondria;Molecular;Morphology;mutant;Names;novel;novel strategies;Obesity;Organelles;Pathologic;Phenotype;Phosphorylation;Phosphorylation Site;Process;Proteins;recruit;Regulation;response;Role;Signal Transduction;Site;spatiotemporal;superresolution microscopy;System;Testing;Transmission Electron Microscopy;Tubular formation;Vesicle

PROJECT_TITLE: Discovering the new function of DRP1 on lipid metabolism

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE The purpose of this project is to resolve the molecular mechanisms of how a shared mutation in the “driver” oncogene PIK3CA, among the most commonly mutated human cancer genes, can elicit a specific immune response. Studying the structural, biophysical, and cellular response to this shared neoantigen will enable an entirely new class of precision immunotherapies targeting a genetic alteration that causes cancer.

PI_NAMEs: KLEBANOFF, CHRISTOPHER AUSTIN (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Adoptive Immunotherapy;Affinity;Alleles;alpha-beta T-Cell Receptor;Antibodies;Antibody Therapy;antigen-specific T cells;Antigens;Autoantigens;Avidity;Binding;Bioinformatics;Biometry;Biophysics;Blood specimen;cancer cell;Cancer Etiology;Cancer Patient;Carcinoma;Catalytic Domain;Cessation of life;chemotherapy;Clone Cells;Colon;Complement;Complex;conventional therapy;cost efficient;curative treatments;Data;Disease remission;Disseminated Malignant Neoplasm;DNA Sequence Alteration;Endometrium;engineered T cells;exhaustion;Exhibits;fitness;Frequencies;gain of function mutation;gene therapy;Gene Transfer;genome sequencing;Genomic approach;Genotype;Growth;Heterogeneity;HLA Antigens;hormone therapy;Human;Immune;Immune response;immuno-gene therapy;immunogenic;immunogenicity;Immunogenomics;Immunologic Monitoring;Immunologics;Immunotherapy;Individual;individual patient;inhibitor;innovation;Kinetics;Knowledge;Malignant Breast Neoplasm;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Memory;Molecular;multidisciplinary;mutant;Mutate;Mutation;neoantigens;Neoplasm Metastasis;novel;novel strategies;novel therapeutic intervention;Oncogenes;Pathway interactions;patient subsets;Patients;Peptides;personalized immunotherapy;PIK3CG gene;Population;Pre-Clinical Model;Privatization;Process;programmed cell death protein 1;Property;Proteins;Reagent;Resistance;response;Somatic Mutation;structural biology;Structure;T cell response;T-Cell Development;T-Cell Receptor;T-Cell Receptor Genes;T-Lymphocyte;Testing;therapeutic target;Time;Toxic effect;translational approach;TRB@ gene cluster;tumor;Tumor Antigens;tumor immunology;Viral;Viral Antigens;Work;X-Ray Crystallography

PROJECT_TITLE: Molecular mechanisms of T cell responses to a clonal neoantigen resulting from a mutated driver oncogene.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


ADMINISTERING_IC: AA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

ORG_CITY: OAKLAND

ORG_NAME: PUBLIC HEALTH INSTITUTE

PHR: PUBLIC HEALTH RELEVANCE The proposed Center provides resources, training, data and statistical expertise for the study of alcohol-related health, mental health and social problem disparities in the US arising from differences between racial/ethnic and socioeconomic group and sexual identity and rurality. Research projects will provide insights in to the drinking of those with alcohol-related health conditions, racial/ethnic and socioeconomic disparities in alcohol-related problems, the role of inflammation in associations between alcohol use and mental health issues, disparities in access and utilization of screening for alcohol problems, use of pharmacotherapy and treatment completion, co- use of alcohol and other drugs, and events involving high-intensity drinking and drinkers who participate in them. Knowledge gained will further understanding of alcohol-related disparities and will strengthen the design, implementation and targeting of interventions to address these.

PI_NAMEs: KERR, WILLIAM C. (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: access disparities;Address;Adopted;Adult;African American population;Alcohol abuse;alcohol and other drug;Alcohol consumption;alcohol epidemiology;alcohol related problem;alcohol research;alcohol screening;alcohol services;alcohol-related injury;Alcohols;analytical method;Applied Research;Area;Attention;Behavior;Black Populations;Black race;Cannabis;career;career development;Caring;Characteristics;Classification;Collaborations;Communities;comorbidity;Complex;Consensus;Consumption;cost;Creativeness;Data;data management;Data Set;design;Development;Diabetes Mellitus;Disparity;Disparity population;drinking;Drug usage;Economics;Environment;Epidemiology;epidemiology study;ethnic disparity;Ethnic Origin;Etiology;European;Event;experience;Faculty;Gender;gender minority status;General Population;Geography;Grant;Health;Health Care Reform;health disparity;Health Policy;Heart;Heavy Drinking;high intensity drinking;high risk;high risk drinking;Hispanic Populations;improved;Incidence;Individual;Inequality;Inflammation;information gathering;Infrastructure;innovation;insight;International;Intervention;Knowledge;knowledge base;Latino;Latino Population;Life Cycle Stages;Link;Measurement;Measures;Mediator;medical specialties;Mental Health;Mentors;Methodological Studies;Methodology;Methods;Minority Groups;minority investigator;Modeling;Morbidity - disease rate;mortality;multidisciplinary;National Institute on Alcohol Abuse and Alcoholism;Neighborhoods;Outcome;Pattern;Pharmacotherapy;Phase;physical conditioning;Policies;Population;Postdoctoral Fellow;pre-doctoral;Prevalence;Productivity;psychologic;psychosocial;Public Health;public health relevance;public policy on alcohol;Race;racial disparity;Research;Research Project Grants;Resources;Risk;Risk Behaviors;Risk Factors;Role;rurality;Sampling;Science;Scientist;screening and brief intervention;Series;Services;Sexual and Gender Minorities;sexual identity;skills;social culture;Social outcome;Social Problems;socioeconomic disadvantage;socioeconomic disparity;Socioeconomic Status;socioeconomics;Source;Statistical Methods;Subgroup;substance use;success;Surveys;synergism;Techniques;Testing;therapy development;Time;Training;Training Programs;Translating;Translational Research;trend;United States National Institutes of Health;Universities

PROJECT_TITLE: Epidemiology of Alcohol Problems: Alcohol-Related Disparities


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

PROJECT_TERMS: Achievement;Address;Alcohol abuse;Alcohol consumption;alcohol epidemiology;alcohol research;Alcohols;Area;Asian Americans;career;career development;Climate;Collaborations;Communication;community organizations;cooking;Data;Data Collection;Development;Disparity;drinking;Drug usage;Education;Ensure;ethnic disparity;Evaluation;experience;Fostering;Goals;Grant;Health;Health Disparities Research;health disparity;Health Services;high intensity drinking;Information Technology;International;Lead;Leadership;Library Services;Link;meetings;Mental Health;Mentored Research Scientist Development Award;Mentors;Mission;Monitor;multidisciplinary;National Institute on Alcohol Abuse and Alcoholism;Outcome;Postdoctoral Fellow;Principal Investigator;Productivity;programs;Public Health;public policy on alcohol;racial disparity;Recording of previous events;Research;Research Personnel;Research Project Grants;Research Training;Resources;Risk Behaviors;Role;Scientist;Services;skills;Social Problems;socioeconomic disparity;sound;Specialist;statistics;stem;Structure;Surveys;synergism;Training;Training Activity;Translations;trend analysis;Universities;Update;Visit;Work;Writing

PROJECT_TITLE: Administration


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Hematology;Neurosciences;Orphan Drug;Pain Research;Rare Diseases;Sickle Cell Disease

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Sickle cell disease (SCD) is a disparity illness afflicting 100,000 Americans, most of whom are Black, and is more costly per-capita than any other chronic disease. The proposed work aims to improve SCD care by 1) developing reliable, valid retinal metrics to measure disease severity and predict long-term complications and 2) improving our understanding of how cellular mechanisms correspond to clinical phenotypes. As novel therapies for SCD continue to emerge, these data are urgently needed to personalize choice, initiation and dosing of therapies to ensure the best outcomes for individuals with SCD.

PI_NAMEs: CHUI, YUEN PING TOCO;GLASSBERG, JEFFREY AVINS (contact)

PROGRAM_OFFICER_NAME: HAILU, BENYAM

PROJECT_TERMS: adaptive optics;Affect;Age;American;Angiography;Area;beta Globin;Biological;Biological Assay;Biological Markers;biomarker signature;Black American;Black race;Blood capillaries;Blood flow;Blood Vessels;Body System;Caring;Categories;cell injury;Cessation of life;Chronic Disease;Classification;Clinical;clinical biomarkers;Clinical Data;clinical heterogeneity;Clinical Pathology;clinical phenotype;cohort;cost;Data;Data Collection;Data Element;data registry;Data Sources;Databases;density;Development;Disease;disease phenotype;Disparity;Dose;Ensure;Environmental sludge;Erythrocytes;Evaluation;Event;Exhibits;Eye;FDA approved;follow-up;Frequencies;Funding;Goals;health care availability;Hematological Disease;Hemolysis;Hour;Image;Image Analysis;Imaging technology;improved;improved outcome;in vivo;indexing;Individual;Individuality;Inequity;innovation;Interruption;Laboratories;Leukocytes;Light;Maps;Measurement;Measures;Mediating;Monitor;Morbidity - disease rate;mortality;mortality risk;National Heart, Lung, and Blood Institute;non-invasive imaging;Normal Cell;Normal Range;novel;novel strategies;novel therapeutics;Ophthalmology;Ophthalmoscopy;Optical Coherence Tomography;Organ;Outcome;Pain;Pathology;Patient Outcomes Assessments;Performance;Perfusion;perfusion imaging;Phenotype;premature;Prospective cohort;Prospective, cohort study;quantitative imaging;Race;Rare Diseases;Reference Values;Research;Research Design;Retina;retinal damage;Retinal Diseases;retinal imaging;retinal ischemia;rho;Scanning;Severity of illness;sex;Sickle Cell;Sickle Cell Anemia;Standardization;Stigmatization;success;time interval;tool;treatment response;Uncertainty;United States National Institutes of Health;Variant;Visit;Visualization;Work

PROJECT_TITLE: SCD REVIVE - Retina to Evaluate Vaso occlusion In the Vasculature of the Eye


NIH_SPENDING_CATS: Clinical Research;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE  Although electronic health records (EHR) data represent a huge opportunity for cost-effective clinical and public health research, care is needed since it typically not collected for that purpose. Among the many challenges that researchers face in using EHR data, missing data poses a substantial, complex and yet unappreciated threat to validity. Motivated by our teams experience in conducting research of long-term outcomes following bariatric surgery, this proposal aims to develop a suite of novel, innovative statistical tools for dealing with missing data in EHR-based studies.

PI_NAMEs: HANEUSE, SEBASTIEN  (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Address;Attention;bariatric surgery;Caring;Clinical;cohort;Cohort Studies;Complex;cost effective;cost efficient;Data;Data Provenance;Decision Making;design;Electronic Health Record;electronic health record system;Eligibility Determination;epidemiology study;Ethics;experience;Face;flexibility;Health Personnel;Health system;innovation;Literature;Longitudinal Studies;Measurement;Methodology;Methods;novel;Observational Study;opportunity cost;Outcome;Patients;Probability;prospective;public health research;randomized trial;Research;Research Design;Research Personnel;Sampling;Selection Bias;semiparametric;Series;Specific qualifier value;Statistical Methods;Techniques;Time;tool

PROJECT_TITLE: Robust methods for missing data in electronic health records-based studies

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

PHR: PUBLIC HEALTH RELEVANCE The implementation of the 2024 National Alcohol Survey will deepen our knowledge of how to collect high quality survey data and biological samples, responding to contemporary survey research challenges. Expanding the NAS series to 45 years will provide us with new data to develop and examine up-to-date trends in alcohol use and problems, and potential disparities in the risk for alcohol-related problems across gender, socioeconomic and racial/ethnic groups. We will also learn whether inflammation partially explains alcohol's effect on psychological distress, and address disparities in these effects among racial/ethnic groups, level of education, and neighborhood status.

PI_NAMEs: MARTINEZ, PRISCILLA  (contact)

PROJECT_TERMS: Address;Adult;Age;Alcohol abuse;Alcohol consumption;alcohol effect;alcohol epidemiology;alcohol measurement;alcohol related problem;alcohol research;alcohol risk;alcohol use disorder;Alcoholic beverage heavy drinker;Alcohols;Anxiety;Area;Back;Beverages;Biological;Black Populations;Blood;Blood Tests;burden of illness;Cannabis;Censuses;Characteristics;cohort;Collection;Communities;Consumption;Data;Data Analyses;Data Collection;Deaths of despair;design;Disparity;drinking;Dryness;Educational Status;Epidemiology;ethnic disparity;Ethnic Origin;Ethnic Population;falls;Future;Gender;gender difference;group intervention;hazardous drinking;Health;Heavy Drinking;improved;Individual;Inflammation;inflammatory marker;innovation;Interdisciplinary Study;Internet;Knowledge;Latino Population;Learning;Legal;Link;Longitudinal trends;low socioeconomic status;Marijuana;marijuana legalization;marijuana use;Measures;Mediator;Mental Depression;Mental Health;Methodology;Methods;middle age;Modeling;Modernization;Monitor;Morbidity - disease rate;mortality;neighborhood disadvantage;Neighborhoods;NR4A1 gene;older adult;Online Systems;opioid epidemic;Outcome;Pattern;perceived stress;Pharmaceutical Preparations;pilot test;Policies;Population;population survey;Positioning Attribute;preventive intervention;Probability;psychological distress;public health relevance;public policy on alcohol;Race;racial disparity;racial population;Recreation;recruit;Research;Research Personnel;Respondent;Risk;Risk Factors;Sales;Sampling;Series;sociodemographics;socioeconomic disparity;socioeconomics;Source;Spottings;Standardization;Subgroup;Survey Methodology;Surveys;Symptoms;Taxes;Techniques;Testing;Time;trend;trend analysis;Woman

PROJECT_TITLE: National Alcohol Surveys: Advancing Epidemiologic Analyses of 21st Century Drinking


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Pediatric;Pediatric Cardiomyopathy;Rare Diseases

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Hypertrophic cardiomyopathy (HCM) is a disease caused by mutations in the contractile proteins. Early in HCM the blood vessels also fail to function correctly, but this aspect is poorly understood. We aim to study the mechanisms that underlie the loss of vessel function and its role in HCM disease progression.

PI_NAMEs: GOLDSPINK, PAUL H;SOLARO, R JOHN;WOLSKA, BEATA M. (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Agonist;Basic Science;Biochemical;Biophysics;Blood capillaries;Blood flow;Blood Vessels;Cardiovascular Diseases;Cells;Clinical;Clinical Research;Contractile Proteins;Coronary;Coronary artery;coronary vasculature;coronary vasodilator;Cytoskeletal Proteins;Data;Defect;Development;Dimensions;Disease;Disease Progression;Early identification;Early Intervention;effective therapy;endophenotype;Endothelial Cells;Endothelium;Etiology;Excision;experimental study;Extracellular Matrix;Female;Functional disorder;Generations;Genes;Genetic Diseases;Geometry;Heart;heart function;Histology;Hypertrophic Cardiomyopathy;Impairment;improved;individualized medicine;inorganic phosphate;Intervention;Investigation;Ischemia;Knock-out;Knowledge;Link;male;mechanical signal;mechanotransduction;Mediating;Mediator;Microfilaments;Modeling;Modification;Monitor;mouse model;Mus;Muscle Cells;Mutation;Neonatal;novel;paracrine;Pathology;Pathway interactions;Population;prevent;Property;protective effect;Proteins;receptor;Receptor Signaling;Regulation;Reporter;Reporting;response;restoration;RiboTag;Role;Sarcomeres;Signal Pathway;Signal Transduction;small molecule inhibitor;Testing;Therapeutic Intervention;therapeutic target;Thin Filament;Time;Translational Regulation;Translations;translatome;Vascular Diseases;vascular endothelial dysfunction;Vascular remodeling

PROJECT_TITLE: Signaling To and From the Vascular/Endothelial Compartment and Progression of HCM Linked to Sarcomere Mutations

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The Huntsman Cancer Institute (HCI) Cancer Genetics, Epigenetics, Models, and Signaling (Cancer GEMS) Training Program will support six PhD candidates each year. Students will participate in a two-year training program consisting of a combination of mentored research, didactic courses, career development activities, seminars, and conferences, all aimed at preparing these young scientists for the next stage of their careers in cancer research. This program will produce a cadre of new scientists capable of working with physicians to develop improved and individualized methods of cancer prevention, early detection/interception, and treatment.

PI_NAMEs: AYER, DONALD E (contact);HOLMEN, SHERI L;TAVTIGIAN, SEAN VAHRAM

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: cancer genetics;Epigenetic Process;Malignant Neoplasms;Modeling;Signal Transduction;Training Programs

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE T cells have the potential to recognize and eliminate cancer cells. However, in most patients with cancer, T cells have lost the ability to kill targets. We will determine how T cell receptor signaling and cell cycling regulate whether or not T cells in tumors function and kill cancer cells.

PI_NAMEs: PHILIP, MARY  (contact)

PROJECT_TERMS: anti-cancer;Antigens;ATAC-seq;Back;Breast;cancer cell;cancer genetics;cancer immunotherapy;Cancer Model;cancer type;CD8-Positive T-Lymphocytes;Cell Cycle;Cell Cycle Kinetics;Cell Cycle Regulation;Cell Differentiation process;Cell division;Cell Reprogramming;Chronic;cytokine;cytotoxic;Defect;Development;Disease remission;effector T cell;Epigenetic Process;epigenome;Functional disorder;functional restoration;Genetic;genetic approach;Genetic Transcription;Human;immune checkpoint blockade;Immune response;Immunotherapy;improved;insight;Liver;liver cancer model;Liver neoplasms;Lung;Malignant - descriptor;Malignant neoplasm of liver;Malignant Neoplasms;Mammary Neoplasms;Maps;Mediating;Melanoma;mouse model;Mus;Nature;Ovarian;Pathway interactions;Patients;PD-1 blockade;pharmacologic;pluripotency;pre-clinical;prevent;Process;programmed cell death protein 1;programs;Proliferating;receptor;Receptor Cell;Receptor Signaling;response;Role;Signal Transduction;Solid Neoplasm;stem cell proliferation;T cell differentiation;T-Cell Receptor;T-Lymphocyte;Testing;therapeutic evaluation;transcriptome sequencing;tumor;Tumor Antigens;Tumor-Infiltrating Lymphocytes

PROJECT_TITLE: TCR signaling and cell cycle regulation in tumor-specific CD8 T cell dysfunction

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Genetics;Lung;Pulmonary Fibrosis;Rare Diseases

ORG_DEPT: ANESTHESIOLOGY

PHR: PROJECT NARRATIVE Accidental exposure to the halogen gas, chlorine (Cl2), causes fatal lung injury characterized by profound airway inflammation, pulmonary edema and acute respiratory failure. Survivors often display persistent reactive airway disease and progressive pulmonary fibrosis. This study will determine if mitochondria DNA damage underlies Cl2 toxicity and whether repairing mitochondrial DNA can reduce morbidity and mortality.

PI_NAMEs: GILLESPIE, MARK N;MATALON, SADIS  (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Accidents;Acute;Acute Lung Injury;Acute Respiratory Distress Syndrome;Acute respiratory failure;Address;Adenovirus Vector;Adult;Air;Airway Disease;airway epithelium;airway inflammation;alveolar epithelium;Alveolar Macrophages;Animal Model;Bioenergetics;Biological Markers;Cell Death;cell injury;cell type;Cells;Chemicals;Chlorine;chlorine gas;Chronic;Chronic Lung Injury;Chronic Obstructive Pulmonary Disease;cytokine;cytotoxic;Data;Development;Disease;Distal;DNA Damage;DNA glycosylase;Effector Cell;Elements;Endosomes;Epithelial Cells;epithelial Na+ channel;Epithelium;Etiology;Event;experimental study;exposed human population;Exposure to;extracellular;Female;Functional disorder;gas induced lung injury;Gases;genome integrity;Halogens;Human;human subject;improved;In Vitro;in vivo;indexing;Inflammation;Inflammatory;Inhalation;Injury;innovation;Intranasal Administration;Ion Transport;Kinetics;Knockout Mice;Light;Link;Lung;lung injury;Macrophage;Maintenance;male;Measures;Mediating;Membrane Potentials;Methodology;Mitochondria;Mitochondrial DNA;mitochondrial genome;mitochondrial membrane;Modeling;Molecular;Molecular Target;Morbidity - disease rate;mortality;Mus;novel;Nuclear;Nucleic Acids;OGG1 gene;outcome prediction;oxidant stress;oxidative damage;Oxygen Consumption;Pathologic;Pathway interactions;Pattern;Pattern Formation;pharmacologic;Physiological;Plasma;Publishing;Pulmonary Edema;Pulmonary Fibrosis;Reactive Oxygen Species;receptor;Receptor Activation;Recombinants;reconstitution;regenerative;repaired;Reporting;Rodent;Seminal;Sentinel;Severities;Signal Transduction;Slice;small hairpin RNA;Small Interfering RNA;Sodium Channel;Stimulator of Interferon Genes;Surrogate Markers;Survivors;Symptoms;Testing;Time;Toxic effect;trafficking;Transgenic Mice;Type II Epithelial Receptor Cell;weapons;Work

PROJECT_TITLE: Mitochondrial DNA Injury is a Key Contributor to the Development of Chemical Lung Injury

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

PHR: PUBLIC HEALTH RELEVANCE A large segment of the US population lives with chronic conditions adversely affected by drinking. Given our integrative approach, study findings will uniquely contribute to the knowledge base for multi-faceted interventions that can simultaneously address harmful drinking and other risk behaviors to help improve disease management, treatment adherence and overall health of individuals with alcohol-related health problems. Our results concerning disparities in knowledge and behaviors across demographic subgroups will help identify those at high risk for continued drinking with health conditions and inform contextually-relevant interventions targeted at them.  .

PROJECT_TERMS: Address;Adult;Affect;Age;age difference;Age of Onset;Agreement;Alcohol abuse;Alcohol consumption;alcohol epidemiology;Alcohols;Area;Attention;Behavior;cancer diagnosis;Cancer Survivor;Cannabis;Cardiovascular Diseases;Characteristics;Chronic;cooking;Coronary;Data Sources;Diabetes Mellitus;Diagnosis;Disadvantaged;Discrimination;Disease Management;disorder risk;Disparity;Disparity population;drinking;drinking behavior;Drug usage;Education;epidemiological model;Equation;Ethnic Origin;Ethnic Population;Evaluation;experience;Frequencies;Gender;General Population;Health;Health behavior;health disparity;Health Information National Trends Survey;Heart;Heavy Drinking;high risk;high risk drinking;Hispanic;Hypertension;Illicit Drugs;improved;Individual;Industry;Intervention;Knowledge;knowledge base;Life Cycle Stages;Life Style;Malignant Neoplasms;Marijuana;Measures;Mental Health;Modeling;Morbidity - disease rate;mortality;mortality risk;multi-component intervention;multiple chronic conditions;National Cancer Institute;Obesity;Outcome;Overweight;Patient Self-Report;Pattern;Physical activity;physical inactivity;Population;Predictive Factor;predictive modeling;programs;public health relevance;Race;racial population;Research;Respondent;Risk;Risk Behaviors;Risk Factors;Role;Sampling;Socioeconomic Status;Source;Subgroup;substance use;Surveys;therapy development;Tobacco;treatment adherence;Uncertainty

PROJECT_TITLE: Health Disparities in Alcohol Use and Other Risk Behaviors after the Onset of Cancers and Cardiovascular Disease-Related Conditions


ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: An important aspect of atherosclerosis is the interaction of immune system cells (macrophages) with lipoprotein deposits in major blood vessels. We are characterizing the cell biology and biochemistry of macrophage-lipoprotein interactions with the long-term goal of basing new therapies on improved understanding of the biological processes.

PI_NAMEs: MAXFIELD, FREDERICK R. (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: 3-Dimensional;Acid Lipase;Actins;AGFG1 gene;Animal Model;Arterial Fatty Streak;Atherosclerosis;Biochemistry;Biological Assay;Biological Process;Blood Vessels;Bone Marrow;Cell Culture Techniques;Cells;Cellular biology;Cholesterol;Cholesterol Esters;Confocal Microscopy;crosslink;Data;Deposition;Development;Electron Microscopy;Enzymes;Event;Exocytosis;extracellular;Extracellular Matrix;Fluorescence Microscopy;Foam Cells;Functional disorder;Generations;Goals;Human;Hydrolase;Hydrolysis;Immune system;improved;in vivo;Inflammasome;Inflammatory;Inflammatory Response;Ions;knock-down;Knockout Mice;Lipids;Lipoproteins;Low-Density Lipoproteins;Lysosomes;Macrophage;Macrophage Activation;Methods;microscopic imaging;Microscopy;Modeling;Molecular;Morphology;mouse model;Mus;novel;novel therapeutic intervention;novel therapeutics;optical imaging;Optics;Phagocytes;phospholipase C gamma;PIK3CG gene;Polymers;Process;Production;Protein Kinase C;Proteins;Publishing;Reporting;Resolution;response;Risk Assessment;RNA Interference;Role;Scanning Electron Microscopy;seal;Signal Pathway;Signal Transduction;Signaling Molecule;Site;Small Interfering RNA;SNAP receptor;Structure;Synapses;Therapeutic Intervention;therapy development;three dimensional structure;Transplantation;TREM2 gene;Work

PROJECT_TITLE: Macrophage-Lipoprotein Interactions

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: The proposed research is relevant to public health and the mission of NIH because the development of bioethics scholars in underdeveloped countries is critical to the health and well-being of its citizens. The COVID-19 pandemic has heightened the need for bioethics experts to address the many ethical issues before them: staffing requirements to care for the public, triage and allocation of scarce resources, public health infection control measures, and end-of-life issues, among others. We will train a total of 6 doctoral candidates to address the critical shortage of highly trained bioethics scholars to address the demand in Tanzania and the region at large.

PI_NAMEs: ULRICH, CONNIE MARIE (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Address;Affect;Ally;Area;Bioethics;Bioethics Consultants;clinical care;Clinical Research;Collaborations;Country;Decision Making;Degree program;Educational process of instructing;Ethical Issues;Ethics;Face;Family;Health;Health Policy;Health Sciences;HIV;Incidence;Individual;Informed Consent;Institution;interdisciplinary collaboration;International;low and middle-income countries;next generation;novel coronavirus;pandemic disease;Patients;Pennsylvania;Prevalence;Public Health;Public Health Schools;recruit;Research;Research Training;Resources;Role;Scholarship;Scientific Advances and Accomplishments;Scientific Inquiry;Services;skills;Social Sciences;success;Tanzania;theories;Training;Training Programs;Universities

PROJECT_TITLE: Educating and Developing Bioethicists in Tanzania (ENGAGE)


ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Gastrointestinal functional and motility disorders affect ~15% of the US population, resulting in chronic morbidity, disruptions in quality of life, loss of productivity and high healthcare costs. Gastrointestinal motility is a complex process that is ultimately executed by the smooth muscle cells. This proposal targets the molecular mechanisms involved in the function and dysfunction in smooth muscle cells, and has the potential to significantly advance basic understanding and potential to provide novel diagnostic approaches and drug targets.

PI_NAMEs: BEYDER, ARTHUR ;FARRUGIA, GIANRICO  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Affect;Animal Model;Bathing;Biological Assay;biophysical properties;Cell Physiology;cell type;Cells;Cellular biology;Chronic;Clinical;Complex;Constipation;Coupling;Data;Diagnosis;diagnostic strategy;Disease;Drug Targeting;Drug usage;Electrophysiology (science);Enterochromaffin Cells;experience;experimental study;Functional disorder;Functional Gastrointestinal Disorders;gastrointestinal;Gastrointestinal Diseases;gastrointestinal function;Gastrointestinal Motility;Gastrointestinal Physiology;gastrointestinal system;Gastrointestinal tract structure;Gene Expression Profile;Genetic Transcription;Goals;Grant;Health;Health Care Costs;Heart;Human;Image;imaging approach;Immune;in vivo;Infection;Inflammation;innovation;Integral Membrane Protein;Interstitial Cell of Cajal;Intestines;Ion Channel;Ions;knock-down;Knowledge;Large Intestine;mechanical force;Mechanical Stimulation;mechanical stimulus;Mechanical Stress;Mechanics;mechanotransduction;Molecular;Molecular Target;Morbidity - disease rate;Motility;motility disorder;Movement;Mus;Muscle;Muscle function;Neuroglia;Neurons;new therapeutic target;Nifedipine;novel;novel diagnostics;Obstruction;Outcome;Patients;Permeability;Population;Process;productivity loss;Quality of life;Reflex action;Regulation;Research;response;Role;sensor;Small Intestines;Smooth Muscle;Smooth Muscle Myocytes;Starling (law);Stretching;Structure;Techniques;Testing;Therapeutic;Time;Tissues;Tomatoes;transcriptomics;Vascular Smooth Muscle;Vascular System;Visceral Myopathies

PROJECT_TITLE: Mechanotransduction in Intestinal Smooth Muscle Cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-H(04)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Neurosciences

PHR: PROJECT NARRATIVE Glutamate receptors are the main mediators of excitatory synaptic transmission. These receptors are involved in learning and memory and a number of other physiological processes, and over or under stimulation of the receptors leads to neurological disorders such as stroke, seizures, Parkinson's disease etc. Here we will study the mechanism of activation and modulation of these receptors using biochemical, imaging and functional methods.

PI_NAMEs: JAYARAMAN, VASANTHI  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Agonist;Binding;Biochemical;Central Nervous System;Characteristics;Classification;Cognition;Color;Computing Methodologies;conformational conversion;Data;delta receptors;dimer;Electrophysiology (science);Fluorescence;Glutamate Receptor;Goals;Image;Investigation;Ion Channel Gating;Ions;Isoxazoles;kainate;Kainic Acid Receptors;Laboratories;Learning;Ligands;Mediating;Mediator;Memory;Methods;Movement;N-Methylaspartate;Nervous System Disorder;Parkinson Disease;Physiological;Physiological Processes;Property;Propionates;protein complex;Protein Subunits;Proteins;receptor;receptor function;Role;Seizures;single molecule;single-molecule FRET;Stroke;Structure;Synapses;Synaptic Transmission

PROJECT_TITLE: Dynamics Of Ligand Gated Ion Channels


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Data Science;Disability Research;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety;Prevention

ORG_CITY: CORAL GABLES

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE Accurate longitudinal monitoring of glaucoma, the leading cause of irreversible blindness in the United States, is critical to identifying disease progression and initiating treatment to prevent permanent visual disability. Current methods used to identify glaucoma progression at the patient level are error-prone due to high variability and infrequency of testing, which can lead to a significant delay in detecting progressive disease. By constructing statistical models enhanced by electronic health record data, this proposal seeks to improve the physician’s ability to rapidly recognize disease progression, thereby enabling early intervention to prevent irreversible vision loss.

PI_NAMEs: SWAMINATHAN, SWARUP SAI (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Adoption;Advisory Committees;African;African American;African Caribbean;Age;Agreement;Algorithms;Applet;Artificial Intelligence;Bayesian Analysis;Bayesian Modeling;Bayesian Prediction;Biometry;Blindness;career;career development;Chronic;Clinical;Clinical assessments;clinical care;Clinical Data;clinical decision-making;clinical encounter;clinical practice;Clinical Research;Communities;Cornea;Country;Data;Data Analyses;Data Science;Databases;Dedications;demographics;design;Disease Progression;Early Diagnosis;Early Intervention;Educational workshop;Elderly;electronic health data;Electronic Health Record;Eligibility Determination;Ethnic Origin;Exhibits;experience;Eye;field study;Florida;Foundations;Frequencies;Future;Glaucoma;Goals;Grant;high risk;Image;improved;indexing;Individual;individual patient;innovation;Institution;Latino;Least-Squares Analysis;longitudinal care;Machine Learning;Masks;Measurement;Medical;meetings;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;Methods;Modeling;Monitor;Nature;novel;Ophthalmology;Optical Coherence Tomography;Outcome;patient population;Patient Self-Report;Patients;Perimetry;personalized predictions;Physicians;Physiologic Intraocular Pressure;Population;population based;Positioning Attribute;predictive modeling;prevent;primary outcome;professor;programs;Progressive Disease;Publications;Race;rapid detection;rate of change;Research;Research Personnel;Resources;retinal nerve fiber layer;Risk;Risk Factors;Science;Scientist;Self-Help Devices;sex;skills;Specialist;Statistical Methods;Statistical Models;Technology;Testing;Thick;Thinness;Time;Training;United States;Universities;Validation;Visit;Visual disability;Visual Fields;Work

PROJECT_TITLE: Improving Individualized Assessments of Glaucoma Progression with Population-Based Electronic Health Record Data


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Immunotherapy;Nanotechnology;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: Los Angeles

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Public Health Relevancy Statement: The proposed research is intended to provide physicians with an entirely new molecular imaging tool that will essentially “paint” the tumor area that needs to be sensitively and specifically identified during and after surgical resection. We recently discovered that the FDA-approved dyes used for coloring of foods, drugs and cosmetics have a multitude of useful imaging properties that are ideal for incorporating into nanoparticles and could be used for highlighting tumors. This approach has great potential to be clinically translated and could significantly improve cancer detection, tumor resection, and identifying the most effective treatment options for the patient; thus, impacting overall therapeutic outcome.

PI_NAMEs: ZAVALETA, CRISTINA L. (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Acceleration;Affinity;Antibody Avidity;antibody conjugate;Area;Binding;Biodistribution;Biological Markers;Cancer cell line;Cancer Detection;cancer imaging;Cancer Patient;cancer type;Cancerous;Candy;career development;Cell Culture Techniques;Cells;Characteristics;Charge;chemical conjugate;chemical property;Chemicals;Circulation;Clinical;clinical translation;Clothing;Color;contrast imaging;Contrast Media;Cosmetics;cost effective;CTLA4 gene;Curiosities;Decision Making;design;Drug Targeting;Dyes;effective therapy;Ensure;Epidermal Growth Factor Receptor;Esthetics;Excision;Extravasation;fabrication;Failure;FDA approved;Flow Cytometry;Fluorescence;fluorescence imaging;Food;Goals;Gold;Growth;Half-Life;Health Care Costs;Hispanic;Household;Human;human tissue;Image;image guided;Image-Guided Surgery;imaging approach;imaging capabilities;Imaging Device;imaging modality;imaging potential;imaging probe;imaging properties;Imaging technology;Immunotherapy;improved;In Vitro;in vivo;in vivo evaluation;individual patient;innovation;Ligands;Location;Malignant Neoplasms;Maps;Modeling;Molecular;Molecular Analysis;molecular imaging;Molecular Profiling;Monoclonal Antibodies;Morbidity - disease rate;mouth squamous cell carcinoma;Multimodal Imaging;multimodality;multiplexed imaging;Mus;nano;nanoparticle;novel;Operative Surgical Procedures;optical imaging;Optics;Outcome;overexpression;Paint;patient stratification;Patient-Focused Outcomes;Patients;Performance;Permeability;personalized medicine;Pharmaceutical Preparations;Physicians;Postoperative Period;pre-clinical;predicting response;Prediction of Response to Therapy;professor;programmed cell death protein 1;Property;Protein Analysis;Proteins;Public Health;Publishing;Repeat Surgery;Research;Resected;Resolution;Sensitivity and Specificity;Silicon Dioxide;Source;specific biomarkers;Surface;Surgeon;targeted biomarker;targeted treatment;tenure track;Testing;Therapeutic;therapy design;therapy outcome;Time;Toxic effect;Translating;treatment planning;Treatment Protocols;treatment response;treatment stratification;tumor;Tumor Debulking;tumor growth;Tumor Tissue;Visit;Xenograft Model

PROJECT_TITLE: A New Multimodal Molecular Imaging Approach to Guide Intra-Operative Tumor Resection and Post-Operative Treatment Planning


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Screening and Brief Intervention for Substance Misuse;Social Determinants of Health;Substance Misuse

PHR: PUBLIC HEALTH RELEVANCE Unhealthy drinking and alcohol use disorder (AUD) together affect more than one of every four American adults and are a leading cause of preventable death, with tremendous economic and social costs. This study seeks to increase understanding of gaps in the quality of alcohol-related care received among unhealthy drinkers and persons with AUD, and how this is changing with health reform. Based on analyses of national survey and specialty treatment data, study results may help to stimulate efforts of clinicians, healthcare administrators, treatment providers, and policymakers to improve access to quality alcohol-related care for all.

PI_NAMEs: MULIA, NINA  (contact)

PROJECT_TERMS: access disparities;Accounting;addiction;Address;Administrator;Adopted;Adult;Affect;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol epidemiology;alcohol screening and brief intervention;alcohol services;alcohol use disorder;Alcoholic beverage heavy drinker;Alcohols;American;Attention;behavioral health;Behavioral Model;Behavioral Risk Factor Surveillance System;Black Populations;Caring;Chronic;Clinical;comorbidity;contextual factors;cost;County;Data;Data Set;Discrimination;Disparity;disparity reduction;drinking;Economics;Enabling Factors;Ensure;Equity;ethnic disparity;Ethnic Origin;experience;falls;gender difference;Guidelines;Health;health care disparity;health care model;health care quality;Health Care Reform;health disparity populations;Health Personnel;Health Services;Health Services Accessibility;Healthcare;Heavy Drinking;high intensity drinking;Improve Access;improved;Individual;Inequity;Institute of Medicine (U.S.);Insurance;Insurance Coverage;integrated care;Latino Population;Low income;low socioeconomic status;Maximum Likelihood Estimate;Medicaid;Medical Care Costs;medical specialties;Mental Health;Mental Health Services;Methods;Minority;Morbidity - disease rate;mortality;National Institute on Alcohol Abuse and Alcoholism;Nature;opioid use disorder;Outcome;parity;Patient-Focused Outcomes;Patients;Pattern;Persons;Pharmaceutical Preparations;Pharmacotherapy;physical conditioning;Policies;Policy Maker;Population Study;Prevalence;preventable death;Prevention;Primary Care;Privatization;Provider;psychiatric comorbidity;public health relevance;Quality of Care;Quasi-experiment;Race;racial disparity;Recommendation;Recording of previous events;Recurrence;Relapse;Reporting;Research;service providers;service utilization;Services;Severities;social;socioeconomic disparity;socioeconomics;Subgroup;Surgeon;Surveys;System;Time;tool;Treatment Factor;Woman;young adult

PROJECT_TITLE: Quality of Alcohol-Related Care Received: Missed Opportunities, Disparities and Impacts of Health Reform


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: SAN DIEGO

ORG_NAME: SINOPIA BIOSCIENCES, INC.

PHR: Project Narrative Levodopa is the primary treatment for Parkinson’s Disease, a neurodegenerative disease that afflicts 1 million Americans. Unfortunately, levodopa has serious side effects and loses its efficacy over time. Using Sinopia Biosciences’s computational drug discovery platform, we identified a small molecule that we subsequently tested and validated in relevant rodent and primate models, providing a unique mechanism for treating Parkinson’s Disease. This proposal will complete preclinical drug development for this compound in order to advance to the clinic.

PI_NAMEs: BORDBAR, AARASH  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, FLOY ANNETTE

PROJECT_TERMS: Acute;Adjuvant;Affect;Agonist;American;antagonist;behavior test;Biological Sciences;Brain;candidate selection;Cardiac;Case Study;Chronic;Climacteric;Clinic;Clinical;clinical development;Cognitive deficits;cognitive task;cognitive testing;computational platform;Data;Data Set;Development;disability;Discrimination;Disease;Dopamine;dosage;Dose;drug discovery;Drug Kinetics;effective therapy;efficacy study;Exposure to;Funding;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Germany;Half-Life;Human;improved;In Vitro;in vivo;inhibitor;L-DOPA induced dyskinesia;Legal patent;Lesion;Levodopa;Link;Literature;Liver Microsomes;Machine Learning;Metabolism;metabotropic glutamate receptor 4;Modeling;Motor;motor behavior;motor symptom;MPTP Poisoning;Mus;nerve stem cell;Neurodegenerative Disorders;Neuronal Differentiation;Neurons;novel;novel therapeutics;older patient;Oxidopamine;Parkinson Disease;Patients;Pattern;Penetration;Performance;Pharmaceutical Preparations;Pharmacological Treatment;Pharmacology;Phase;Physicians;Positioning Attribute;pre-Investigational New Drug meeting;preclinical development;Preclinical Drug Development;preclinical efficacy;preclinical study;Primates;Property;Rattus;response;Rodent;Safety;Secure;side effect;small molecule;Surveys;symptom treatment;Symptoms;Testing;Therapeutic;Time;Toxicology

PROJECT_TITLE: Preclinical development of a novel therapeutic for Parkinson's disease


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biotechnology;Immunization;Immunotherapy;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: ATHENS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: PUBLIC HEALTH RELEVANCE: Pneumocystis jirovecii is the causative agent of Pneumocystis pneumonia (PCP), which remains a life-threatening illness of increasing concern in individuals with weakened immune systems. The research proposed research will further advance a vaccine candidate and immune-therapeutic for the prevention and treatment of PCP in immunocompromised individuals. The successful completion of these studies will advance these vaccine candidate and immunotherapeutics toward clinical trials.

PI_NAMEs: NORRIS, KAREN A (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Acute;Address;Adverse reactions;Aging;Animals;Antibiotics;Antibodies;Antibody titer measurement;antiretroviral therapy;Autoimmune Diseases;Bone Marrow Transplantation;Cancer Patient;Chemotherapy-Oncologic Procedure;Chronic Obstructive Pulmonary Disease;Clinical;Clinical Research;Clinical Trials;clinically relevant;Collagen;Crohn's disease;Data;Death Rate;Defect;Development;Diagnosis;Diagnostic;Disease;Drug resistance;Environment;experience;Exposure to;Generations;Goals;Guidelines;Hematologic Neoplasms;HIV;Human;Humoral Immunities;Hyperimmunoglobulin M Syndrome;Immune;Immune response;Immune system;Immunity;Immunization;Immunocompromised Host;immunosuppressed;Immunosuppression;Immunotherapeutic agent;Impairment;improved;Incidence;Individual;Infection;Infection Control;Inflammatory;innovation;innovative technologies;insight;Life;Lung;lung injury;Macaca mulatta;Memory;Modeling;Monkeys;Monoclonal Antibodies;Morbidity - disease rate;mortality;natural antibodies;Nature;nonhuman primate;novel therapeutics;Obstructive Lung Diseases;Opportunistic Infections;opportunistic pathogen;Organ;organ transplant recipient;Organ Transplantation;Organism;pathogenic fungus;patient population;Patients;Persons;Pharmaceutical Preparations;Pneumocystis;Pneumocystis carinii;Pneumocystis carinii Pneumonia;Pneumocystis Infections;Pneumonia;Population;pre-clinical;Pre-Clinical Model;prevent;Prevention;Prevention strategy;Preventive;prophylactic;Prophylactic treatment;Prospective Studies;protective efficacy;Protein Subunits;public health relevance;pulmonary function;Pulmonary Pathology;Recombinant Proteins;recurrent infection;Regimen;Reporting;Research;Resolution;Resource-limited setting;response;Rheumatoid Arthritis;Risk;Role;seropositive;Severe Combined Immunodeficiency;SIV;Solid;Solid Neoplasm;Subunit Vaccines;Testing;Therapeutic;Therapeutic immunosuppression;Therapeutic Uses;Transplant Recipients;Treatment Failure;Trimethoprim-Sulfamethoxazole;vaccine candidate;vaccine development;Vaccines;Vascular Diseases;Virus Diseases;Work

PROJECT_TITLE: Prevention and Treatment of Pneumocystis Pneumonia

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ORG_CITY: SAN FRANCISCO

ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

PHR: Post-traumatic stress disorder (PTSD) is a common consequence of combat that can result in trauma-related hyperarousal and sleep disturbances. Poor sleep, one of the most common complaints in Veterans with PTSD, can be distressing, impair concentration and memory, and contribute to physical health conditions, such as metabolic syndrome, inflammation, and cardiovascular disease. The orexin neuropeptide system underlies both sleep and stress reactivity. Suvorexant, a drug that reduces orexin, improves sleep in civilians, but has not yet been tested in Veterans with PTSD. This study will test whether suvorexant can improve sleep disturbances and PTSD symptoms in Veterans. Suvorexant may benefit Veterans by improving sleep quickly while also reducing PTSD symptoms over the long term, and with fewer side effects that were common in previous medications used to treat these conditions. Improving Veterans' sleep and PTSD symptoms could lead to better emotional and physical well-being, quality of life, relationships, and functioning.

PI_NAMEs: INSLICHT, SABRA  (contact)

PROJECT_TERMS: Accounting;actigraphy;Addendum;Adverse effects;antagonist;Arousal;Autonomic nervous system;Binding;Biological;Cardiovascular Diseases;Central Nervous System;Clinical;Clinical Trials;combat;design;Disease;Distress;Dose;Double-Blind Method;Drops;Drowsiness;Drug Targeting;DSM-V;efficacy evaluation;efficacy testing;Emotional;falls;FDA approved;flexibility;Fright;functional disability;Generations;hypocretin;Impairment;improved;improvement on sleep;indexing;Inflammation;Interview;Learning;learning extinction;Life;Measures;Mediating;Mediator;Memory;Mental Depression;Metabolic syndrome;Military Personnel;Moods;Neuropeptides;Nightmare;Patient Self-Report;Patients;Personal Satisfaction;Pharmaceutical Preparations;Pharmacological Treatment;Phase;Phase IV Clinical Trials;physical conditioning;Pittsburgh Sleep Quality Index;Placebo Control;Placebos;poor sleep;Post-Traumatic Stress Disorders;pre-clinical;primary outcome;promoter;Quality of life;Randomized;receptor;reduce symptoms;Reporting;Safety;Sampling;secondary outcome;Selective Serotonin Reuptake Inhibitor;Severities;side effect;Site;Sleep;Sleep disturbances;sleep onset;sleep regulation;Sleeplessness;Startle Reaction;Stress;stress reactivity;suicidal;Symptoms;System;Testing;Time;Titrations;Trauma;Veterans;vigilance;Wakefulness;week trial;Wrist

PROJECT_TITLE: Suvorexant: A Dual Orexin Receptor Antagonist for Treating Sleep Disturbance inPosttraumatic Stress

STUDY_SECTION: MHBB

STUDY_SECTION_NAME: Mental Health and Behavioral Science B[MHBB]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Prevention;Social Determinants of Health;Substance Misuse

PHR: PUBLIC HEALTH RELEVANCE This work will broaden our knowledge of both the precursors to and the outcomes of high-intensity drinking (HID) at various points over the life course, also estimating the public health burden attributable to high alcohol intake. This research project is poised to improve HID measurement, track HID trends over time, and enhance theory by contextualizing intensity within an individual's overall drinking pattern, drinking history, event-level characteristics, and individual and environmental influences. Finally, this research promises to aid in improving prevention and treatment strategies by better identifying suitable target subgroups (in particular women and disadvantaged populations disproportionately impacted by alcohol problems), and provide information to help shape design of future interventions aimed at reducing harmful drinking intensities among a range of adults, from young adults to middle-aged and older Americans.

PI_NAMEs: LUI, CAMILLIA K. (contact)

PROJECT_TERMS: Acute;Adult;adverse outcome;Age;age related;Alcohol abuse;Alcohol consumption;alcohol epidemiology;alcohol measurement;alcohol poisoning;alcohol related problem;alcohol use disorder;Alcoholic beverage heavy drinker;Alcohols;American;Attention;Beverages;binge drinking;Birth;Blood alcohol level measurement;Characteristics;Clinical;cohort;Cohort Effect;Consumption;Data;design;Development;diaries;Disparity;Disparity population;drinking;Early Intervention;early screening;Education;Emergency department visit;Ensure;Epidemiology;ethnic minority;Ethnic Origin;Event;Family history of;Future;Gender;General Population;Goals;Guidelines;high intensity drinking;high risk;high risk population;improved;Individual;Intake;Internet;Intervention;Knowledge;Life Cycle Stages;Location;Machine Learning;machine learning method;machine learning model;Measurement;men;Methodology;middle age;Mission;Modeling;National Institute on Alcohol Abuse and Alcoholism;older adult;Outcome;Pattern;Persons;Population;population based;preference;Prevalence;Prevention strategy;protective factors;Public Health;public health relevance;Race;racial minority;Recording of previous events;Recovery;Reporting;Research;Research Project Grants;response;Risk;Risk Assessment;Risk Estimate;Risk Factors;Sampling;Series;Shapes;social disparities;Socioeconomic Factors;Statistical Methods;Subgroup;Surveys;theories;Time trend;translational impact;treatment strategy;trend;Woman;Work;young adult

PROJECT_TITLE: High-Intensity Drinking over the Life Course: Identifying High-Risk Subgroups through Event-based and Population-Based Approaches


ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI VA MEDICAL CENTER RESEARCH

ORG_STATE: OH

PHR: Heart failure with reduced ejection fraction (HFrEF) is a common cause for admission and mortality within the Veterans Affairs (VA) Health Care System. Currently its treatment is based on therapeutic targeting of a limited number of receptors and pathways. Our team has shown that the Vanilloid 2 subtype of the Transient Potential Receptor superfamily (TRPV2) modulates cardiac function and we have used probenecid, a generic, globally available drug with an extremely safe profile as a TRPV2 agonist. Our work has demonstrated probenecid to be a potent inotrope without significant adverse effects in animal models and in patients with HFrEF. The objective of this study is the treatment of outpatient veterans with HFrEF with probenecid to improve systolic and health function. If successful, this study will provide a novel therapeutic option for patients with HFrEF and will provide event rates for a larger study with hard endpoints.

PI_NAMEs: JOSEPH, JACOB ;RUBINSTEIN, JACK  (contact);WU, WEN-CHIH

PROJECT_TERMS: Admission activity;Adult;Adverse effects;Agonist;Ambulatory Care;Animal Model;Animals;Apoptotic;Calcium;Cardiac Myocytes;Cardiomyopathies;Cardiovascular Physiology;chronotropic;Cities;Databases;Death Rate;design;Double-Blind Method;Echocardiography;EFRAC;EuroQOL;Event;Exercise stress test;Exercise Test;Exercise Tolerance;Functional disorder;functional status;Future;Gout;Group Hospitalization;Guidelines;Health;Health Status;Healthcare Systems;Heart Diseases;Heart failure;heart failure with reduced ejection fraction;heart function;Hospitalization;improved;In Vitro;in vivo;innovation;Kansas;Laboratories;Left;Left Ventricular Ejection Fraction;Measures;Medical;Medicare;Mental Health;mortality;mouse model;Muscle Cells;novel;novel therapeutics;Oral;Outcome;Outpatients;Pathway interactions;Patient Self-Report;Patients;Pharmaceutical Preparations;pharmacologic;Phase;phase 2 study;physical conditioning;physical impairment;Pilot Projects;Placebo Control;Placebos;Play;Population;Population Study;porcine model;power analysis;pre-clinical;preservation;Prevalence;Private Sector;Probenecid;Public Health;Publishing;Questionnaires;Randomized;receptor;recruit;Retrospective Studies;Risk;Role;Safety;Site;Symptoms;Testing;therapeutic target;treatment duration;United States Department of Veterans Affairs;Vanilloid;Ventricular;Veterans;Veterans Health Administration;Walking;Work

PROJECT_TITLE: Treatment of Veterans with Heart Failure with Reduced Ejection Fraction with Probenecid


ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

PHR: This work is directly applicable to the health, well-being, and functional independence of disabled Veterans suffering from a devastating and currently incurable neurological condition called Parkinson’s disease – a neurodegenerative disorder, affecting about 10 million individuals worldwide, including approximately 80,000 US Veterans. Our goal is to define the most effective therapeutic approach utilizing deep brain stimulation and address balance and falls in Parkinson’s disease. Our top-down approach will unravel the anatomical pathways and physiological processes through which we will better understand multi-sensory governance of motion perception critical for spatial navigation, and maintenance of balance and prevention of falls in Parkinson’s disease.

PI_NAMEs: SHAIKH, AASEF G (contact)

PROJECT_TERMS: Address;Affect;Anatomy;Area;Atlases;Axon;Basal Ganglia;Cell Nucleus;Cerebellum;Clinical;Computer Models;Data;debilitating symptom;Deep Brain Stimulation;design;disabled;Discrimination;Distal;Dorsal;Electrodes;Electronics;equilibration disorder;Equilibrium;experimental study;Fall prevention;falls;Freedom;Functional disorder;functional independence;Gait;Goals;Health;hexapod;Human;Image;Impairment;improved;Individual;insight;Lateral;Location;Maintenance;Maps;Measures;military veteran;Morbidity - disease rate;Motion;Motion Perception;motor disorder;Movement;multidisciplinary;multisensory;Muscle Hypertonia;Neural Pathways;Neurodegenerative Disorders;neuroimaging;Neurologic;Neurology;Operative Surgical Procedures;Outcome;Parkinson Disease;Pathway interactions;Patients;Pattern;Perception;Personal Satisfaction;Persons;Pharmacotherapy;Physiological;Physiological Processes;Physiology;posture instability;preservation;Process;programs;Psychophysics;recruit;Research;Research Personnel;Role;sensory integration;side effect;Signal Transduction;Structure of subthalamic nucleus;System;Techniques;Testing;therapeutically effective;Tissues;tractography;transmission process;Tremor;vestibular system;Veterans;Vision;Visuospatial;Walking;way finding;white matter;Work

PROJECT_TITLE: Subthalamic deep brain stimulation to modulate vestibular heading perception in Parkinson’s disease.


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurosciences;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: CHARLESTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Adolescence is a period of considerable development, making the adolescent brain particularly vulnerable to negative effects of cannabis and alcohol use. The proposed research will test an innovative intervention among adolescents seeking-treatment for substance use that aims to modify automatic approach biases for cannabis and alcohol, which are hypothesized precipitating and maintaining factors for adolescent substance use. The modification of implicit cognitive biases via training may be a useful adjunct to existing interventions and could reduce the consequences associated with adolescent substance use.

PI_NAMEs: HAHN, AUSTIN MATTHEW (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: addiction;Adolescence;Adolescent;adolescent substance use;Adult;Aftercare;Age;Alcohol abuse;Alcohol consumption;alcohol effect;alcohol use disorder;Alcohols;Area;Award;Behavioral;Brain;brief intervention;Cannabis;career;career development;Categories;Clinical Trials;Cognitive;Communication;computerized;Computers;cost;craving;Cues;Data;design;Development;Development Plans;direct application;Drug Exposure;Ecological momentary assessment;Effectiveness;Electroencephalography;emerging adult;Ensure;Environment;EP300 gene;Etiology;Evaluation;Event-Related Potentials;Exhibits;experience;experimental study;Funding;Goals;Image;implicit bias;innovation;Intervention;intervention effect;Joystick;Knowledge;Maintenance;marijuana use;marijuana use disorder;marijuana user;Measures;Mediating;Mediator;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Methods;Modification;National Institute of Drug Abuse;National Institute on Alcohol Abuse and Alcoholism;neglect;Neurocognitive;Neurologic;Participant;Performance;Pharmaceutical Preparations;Play;Portraits;Positioning Attribute;post intervention;Process;Productivity;programs;prospective;Publications;Randomized;Randomized, Controlled Trials;Reporting;Research;Research Personnel;Resources;response;Rewards;Role;Stimulus;Strategic Planning;Structure;substance use;substance use treatment;Testing;Training;underage drinker;underage drinking

PROJECT_TITLE: Approach Bias Modification for Co-Occurring Cannabis and Alcohol Use among Treatment-Seeking Adolescents

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Caregiving Research;Disability Research;Pain Research;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Prevention;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: MINNEAPOLIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Project Narrative Shoulder pain in people living with spinal cord injury is a serious threat to public health, with implications for functional independence, quality of life, caregiver burden, and healthcare utilization. To better understand shoulder pain, researchers have used musculoskeletal models to understand how muscle tendons may be injured during daily activities. Our investigation will use secondary analysis of existing data to understand the relative impact of anatomy versus movement patterns of the shoulder on the muscle tendon during wheelchair propulsion.

PI_NAMEs: LUDEWIG, PAULA MARIE (contact)

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: 3-Dimensional;Address;Affect;Algorithms;Anatomy;Applications Grants;arthropathies;Articular Range of Motion;bone;Caregiver Burden;Clinic;Clinical;clinical application;Clinical Trials;Collaborations;Custom;Data;Data Set;design;Development;Dimensions;Disease;Electromyography;experience;Functional disorder;functional independence;Future;Genetic Models;Geometry;Head;Health;health care service utilization;Immobilization;improved;in vivo;Individual;injured;Institution;interest;Intervention;Investigation;Joint structure of shoulder region;Joints;kinematics;Knowledge;Manual wheelchair;Measures;Methods;Minnesota;Modeling;Motion;Movement;multidisciplinary;Muscle;Musculoskeletal;National Institute of Child Health and Human Development;Outcome;Outcome Assessment;Pain;Participant;Pathology;Pattern;Persons;Population;Positioning Attribute;preservation;pressure;prevent;preventive intervention;Public Health;Quality of life;reconstruction;repaired;Reporting;Research;Research Personnel;Resolution;Resources;Risk;Rotator Cuff;rotator cuff injury;rotator cuff tear;Sample Size;Scanning;scapula;Scientist;secondary analysis;Severities;Shoulder;Shoulder Pain;Site;skeletal;soft tissue;Soft Tissue Disorder;Spinal cord injury;Statistical Data Interpretation;Stress;Structure;Techniques;Technology;Tendon Injuries;Tendon structure;Time;Torque;Transportation;United States;Universities;Upper Extremity;Weight-Bearing state;Wheelchair propulsion;Wheelchair user;Work

PROJECT_TITLE: Mechanisms of Rotator Cuff Injury During Manual Wheelchair Propulsion

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD-K]


NIH_SPENDING_CATS: Arthritis;Behavioral and Social Science;Biomedical Imaging;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Osteoarthritis;Pain Research;Precision Medicine

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Narrative: Chronic pain affects nearly one-third of the United States population, costing approximately $600 billion, more than the annual costs of heart disease, cancer, and diabetes combined. The current proposal aims to improve chronic pain treatment by examining the contribution of central pain inhibition to chronic pain and patient-to-patient heterogeneity of treatment response. Novel brain and behavioral measures developed in this proposal may predict treatment response to established analgesics, personalizing chronic pain management and allowing the study of novel analgesics in phenotypically-defined patient populations.

PI_NAMEs: ALTER, BENEDICT J (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Absence of pain sensation;Acute Pain;Address;Affect;Analgesics;Animal Model;arthritic pain;behavior measurement;Behavioral;Behavioral Paradigm;Blinded;Brain;Brain imaging;career;Central Nervous System;central pain;Chronic;Chronic intense pain;chronic neuropathic pain;chronic pain;chronic pain management;chronic pain patient;Chronic pain syndrome;Clinic;Clinical;clinical pain;Clinical Research;Clinical Trials;cohort;conditioned pain modulation;conditioning;cost;cost effective;Cross-Sectional Studies;Data;Diabetes Mellitus;Distant;distraction;Drops;duloxetine;Evaluation;Functional disorder;functional near infrared spectroscopy;Future;Goals;Hand;healthy volunteer;Heart Diseases;heat stimulus;hemodynamics;Heterogeneity;Human;Imaging Device;Immersion;Impairment;improved;Injury;joint destruction;K-Series Research Career Programs;Knee;Knee Osteoarthritis;knee pain;Knowledge;knowledgebase;Malignant Neoplasms;Measurement;Measures;Medial;meetings;Mentors;Meta-Analysis;Modeling;neural correlate;neuroimaging;Neurosciences Research;novel;osteoarthritis pain;Pain;Pain Free;pain inhibition;Pain intensity;Pain management;Pain Measurement;pain relief;Pain Threshold;Patient Care;patient oriented research;patient population;patient subsets;Patient-Focused Outcomes;Patients;personalized care;personalized medicine;Phenotype;Physicians;Physiological;Population;Positioning Attribute;preclinical study;predicting response;Prediction of Response to Therapy;predictive marker;Prefrontal Cortex;pressure;prevent;programs;prospective;Randomized, Controlled Trials;Recording of previous events;Reproducibility;Research;response;Role;Scientist;secondary analysis;Sensory;Severities;Signal Transduction;Site;skills;somatosensory;Stimulus;Subgroup;Testing;Time;tool;Training;Translational Research;treatment effect;treatment response;United States;Universities;volunteer;Walking;Water;Work

PROJECT_TITLE: Integrating brain and behavioral measures of central pain inhibition to personalize treatment in chronic pain management

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]