NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Cancer;Liver Disease;Prevention;Rare Diseases

PHR: Project Narrative: There are no approved therapies for Non-alcoholic steatohepatitis (NASH), the most severe form of fatty liver disease that affect approximately 20% of the global population. The project is relevant to NIH’s mission because it will focus on understanding the basic mechanisms that leads to the initiation and progression of NASH with the goal of identifying novel targets for early detection, prevention and cure of NASH and hepatocellular carcinoma (HCC). Specifically, the proposed study will dissect the role of TREM2 in orchestrating the progression of fatty liver to NASH, fibrosis and eventually to HCC.

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Affect;Animal Model;Antibodies;Area;Benign;Binding;Bone Marrow;cancer transplantation;cell injury;Cell surface;Cells;chronic liver inflammation;Cicatrix;Cleaved cell;clinical translation;cytokine;Data;Development;Diet;Disease Progression;Early Diagnosis;epigenetic regulation;epigenomics;extracellular;Extracellular Domain;Fatty Liver;fatty liver disease;Fibrosis;Foundations;Functional disorder;Future;Gene Delivery;genetic signature;Goals;Health Care Costs;Hepatocyte;Human;In Vitro;in vivo Model;Inflammatory;insight;Knock-out;Life Style Modification;Ligand Binding;Ligands;Lipids;Liver;Liver diseases;liver injury;liver transplantation;Macrophage;Macrophage Activation;Malignant neoplasm of liver;Measures;Mediating;Membrane;Metabolic syndrome;Mission;Modeling;Molecular;mouse model;Mus;Mutation;Myeloid Cells;new therapeutic target;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel therapeutic intervention;novel therapeutics;overexpression;Pathogenesis;Pathway interactions;Patients;Physiological;Plasma;Play;Population;prevent;Prevention;Primary carcinoma of the liver cells;Property;receptor;Resolution;response;Role;Sampling;Serum;Signal Pathway;Signal Transduction;Site;spheroids;Therapeutic;Therapeutic Agents;Therapeutic Effect;transcription factor;transmission process;TREM2 gene;TYROBP gene;United States National Institutes of Health

PROJECT_TITLE: Dissecting the Intracellular and Extracellular Role of TREM2 in the Pathogenesis of Non-Alcoholic Steatohepatitis.

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Genetics;Hematology;Human Genome;Pediatric;Rare Diseases

ORG_CITY: LA JOLLA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE A novel approach to treating bone marrow failure disorders involves shifting the balance of proliferation and differentiation in hematopoietic progenitor cells in order to increase progenitor proliferative capacity and generate greater numbers of terminally differentiated cells. I recently demonstrated that the balance of proliferation and differentiation in mouse early erythroid progenitors can be manipulated with glucocorticoid or TGFβ signaling, and results in increased (by glucocorticoids) or decreased (by TGFβ) proliferative capacity; however, the molecular mechanisms by which these proliferative capacity alterations occur are unknown and it is unclear if this developmental biology paradigm observed in mice will translate to humans. To begin developing this preliminary finding into novel therapeutic approaches for Diamond-Blackfan anemia, I propose to determine the mechanism for alteration of proliferative capacity of early erythroid progenitor cells by identifying direct gene targets of the transcription factors downstream of glucocorticoid and TGFβ signaling, and also determine if glucocorticoids and TGFβ elicit the same effect on proliferative capacity of erythroid progenitor cells from normal human donors and patients with Diamond-Blackfan anemia.

PI_NAMEs: LI, HOJUN  (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Affect;American Society of Hematology;Anemia;Architecture;Automobile Driving;Award;Basic Science;BFU-E;Binding;Biology;Biomedical Research;Bone Marrow;Bone marrow failure;Boston;career development;Cell Count;Cell Cycle;Cell Differentiation process;Cell division;Cells;CFU-E;Child;Chromatin;Clinical;clinical efficacy;Collaborations;Development;Developmental Biology;Diamond-Blackfan anemia;differential expression;Differentiation Antigens;Disease;disease model;Ensure;Equilibrium;Erythrocytes;Erythroid;Erythroid Cells;erythroid differentiation;Erythroid Progenitor Cells;Erythropoiesis;Erythropoietin;Failure;follow-up;Fostering;Functional disorder;Gene Targeting;Generations;Genes;Glucocorticoid Receptor;Glucocorticoids;GYPA gene;Hematological Disease;Hematopoiesis;Hematopoietic stem cells;Human;improved;inhibitor;insight;Institution;International;MADH2 gene;Malignant Neoplasms;Maps;Marrow;Mediating;Mentors;Molecular;Mus;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Output;Patients;Pharmacotherapy;Physicians;Positioning Attribute;Postdoctoral Fellow;prevent;Principal Investigator;Production;progenitor;Proliferating;Receptor Activation;Receptor Signaling;Repression;Research;research and development;Research Personnel;Resistance;RNA;Science;Scientist;Signal Transduction;single-cell RNA sequencing;skill acquisition;Speed;stem cell differentiation;stem cells;success;Testing;TFRC gene;Therapeutic;Time;Tissues;Toxic effect;Training;Transcript;transcription factor;transcriptome;transcriptomic profiling;transcriptomics;Transducers;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;Translating;Translations;Work

PROJECT_TITLE: Regulating proliferation and differentiation of erythroid progenitors

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: LM

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: LAFAYETTE

ORG_NAME: UNIVERSITY OF LOUISIANA AT LAFAYETTE

ORG_STATE: LA

PHR: Project Narrative The next generation of multidisciplinary investigators will require foundational training and experience in both the life and physical sciences, as well as in computational, mathematical, and engineering disciplines to tackle increasingly complex problems that impact our health. TExBioMed, an education research initiative of the Multi- Interprofessional Center for Health Informatics (MICHI) at the University of Texas at Arlington (UTA), a designated Hispanic Serving Institution, will leverage the institutional commitment to diversity, equity, and inclusion by recruiting and immersing 55 talented undergraduate students from diverse backgrounds in a training environment that will expose them to the current state-of-the-art in biomedical informatics, health and public health informatics, and data science. The program's ultimate goal is to increase the talent pool to fulfill the needs of the nation’s current and future workforce by providing the participating students with unique, hands-on training and research experience that will broaden their view of human health in post-genomic computational and data science research areas and motivate these students to pursue careers in Biomedical Informatics/Data Science fields.

PI_NAMEs: MUSTATA WILSON, GABRIELA  (contact)

PROJECT_TERMS: Active Learning;Address;Area;Bioinformatics;Biological;Biological Sciences;Biology;Biomedical Engineering;biomedical informatics;career;Chemistry;Clinical;college;Complex;Computational Science;computer science;Coupled;Data;Data Science;Discipline;disease diagnosis;Education;education research;Engineering;Environment;Equity;equity, diversity, and inclusion;experience;Faculty;Fostering;Future;Genomics;Goals;Health;health equity;Health Sciences;Hispanic-serving Institution;Human;Institution;Interdisciplinary Study;Laboratories;lectures;mathematical sciences;Mathematics;member;multidisciplinary;next generation;physical science;Physics;programs;Public Health Informatics;recruit;Research;Research Personnel;Series;STEM field;student mentoring;student participation;Students;summer institute;Talents;targeted treatment;Texas;Training;undergraduate student;underrepresented minority student;Universities

PROJECT_TITLE: Training and Experiential Learning in Biomedical Informatics (TExBioMed)


ADMINISTERING_IC: DA

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Patient Safety

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PI_NAMEs: BARSTOW, MATTHEW  (contact)

PROJECT_TERMS: Clinical and Translational Science Awards;common rule;Funding;human subject;human subject protection;Institution;Institutional Review Boards;National Center for Advancing Translational Sciences;operation;Process;programs;Research;Research Support;Site;United States National Institutes of Health

PROJECT_TITLE: SMART IRB GOVERNANCE, ADMINISTRATION, AND OPERATIONS SUPPORT


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PI_NAMEs: LLOYD-JONES, DONALD  (contact)

PROJECT_TERMS: Age;Ancillary Study;cardiovascular disorder risk;Censuses;Chicago;Clinic;Clinical;clinical predictors;cohort;Collaborations;Collection;Communities;Coronary Artery Risk Development in Young Adults Study;Data Collection;Disease;Education;Event;Evolution;follow-up;Fostering;Functional disorder;Goals;health plan;high school;Hospitalization;Injury;interest;member;National Heart, Lung, and Blood Institute;Participant;Population;progression risk;Race;residence;Risk Factors;Sampling;sex;stomach cardia;Subgroup;Vital Status;young adult

PROJECT_TITLE: CORONARY ARTERY RISK DEVELOPMENT IN YOUNG ADULTS (CARDIA) STUDY - CHICAGO FIELD CENTER


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PROJECT_TITLE: CORONARY ARTERY RISK DEVELOPMENT IN YOUNG ADULTS (CARDIA) STUDY - OAKLAND FIELD CENTER


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

ORG_CITY: ROCKVILLE

ORG_NAME: WESTAT, INC.

ORG_STATE: MD

PI_NAMEs: MARTIER, KAREN  (contact)

PROJECT_TITLE: CREUTZFELDT-JAKOB DISEASE SURVEILLANCE IN RECIPIENTS OF HUMAN GROWTH HORMONE


ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PROJECT_TITLE: CORONARY ARTERY RISK DEVELOPMENT IN YOUNG ADULTS (CARDIA) STUDY - BIRMINGHAM FIELD CENTER


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PROJECT_TITLE: CORONARY ARTERY RISK DEVELOPMENT IN YOUNG ADULTS (CARDIA) STUDY - UNIVERSITY OF MINNESOTA FIELD CENTER.


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Public Health Relevance Statement The Human BioMolecular Atlas Program (HuBMAP) aims to create the very first computable, open Human Reference Atlas (HRA). This HRA will redefine our understanding of the human body by recovering multi-scale tissue organization—anatomical, histological, and molecular—at unprecedented resolution, through computational integration of diverse experimental measurements made by expert teams around the globe.

PI_NAMEs: BORNER, KATY  (contact)

PROGRAM_OFFICER_NAME: CONROY, RICHARD

PROJECT_TERMS: 3-Dimensional;Acceleration;Anatomy;Atlases;Automobile Driving;Biological Markers;Biomedical Research;cell type;Cells;clinical practice;Collaborations;Computer Models;Data;data format;Ensure;Genes;Histologic;Human;Human BioMolecular Atlas Program;Human body;human-in-the-loop;Indiana;Infrastructure;International;Libraries;Link;Machine Learning;machine learning algorithm;Maps;Measurement;Modernization;Molecular;Ontology;Paper;public health relevance;Resolution;System;Text;Tissue imaging;tissue mapping;Tissues;Universities;Visualization;Work

PROJECT_TITLE: 3D Multiscale Biomolecular Human Reference Atlas Construction, Visualization and Usage [4 of 5]


NIH_SPENDING_CATS: Bioengineering;Data Science

ORG_DEPT: MISCELLANEOUS

PHR: Public Health Relevance Statement: Efficient access to spatial single cell and bioimaging data generated by consortia such as the  Human BioMolecular Atlas Program (HuBMAP) through data portals and visualizations tools that  are designed based on comprehensive use case and persona analysis enable participation by a  large audience of users across all fields of biology and medicine. We will deliver modern, web-based tools to provide such access and integrate our methods and tools with those of other key  contributors to maximize the scientific impact of the HuBMAP Consortium.

PI_NAMEs: GEHLENBORG, NILS  (contact)

PROJECT_TERMS: 3-Dimensional;Atlases;bioimaging;Biology;Cells;cellular imaging;Communities;Data;Data Analyses;data analysis pipeline;data exploration;data hub;data portal;data visualization;design;file format;Genes;genome browser;Human;Human BioMolecular Atlas Program;Human body;improved;interactive visualization;Maps;Medicine;Methods;Modernization;Pathway interactions;Phase;Production;public health relevance;Research;Tissues;tool;Visual;Visualization;Visualization software;web-based tool

PROJECT_TITLE: Data Exploration and Visualization Tools for HuBMAP and a Human Reference Atlas


ORG_CITY: NEW YORK

ORG_NAME: NEW YORK GENOME CENTER

ORG_STATE: NY

PHR: Public health statement: We propose a Mapping Center as part of the Human Biomolecular Atlas Project  (HuBMAP), that will assist in the construction of a HuBMAP Human Reference Atlas. The reference atlas will  represent a full “parts list” of the human body and it will describe their multi-scale spatial and molecular  organization. Our work aims to deepen our understanding of human cell types and human anatomy, and to  establish a map of the healthy human body that will represent a valuable reference for understanding and  interpreting disease.

PI_NAMEs: MARIONI, JOHN CARLO;SATIJA, RAHUL  (contact)

PROJECT_TERMS: Affect;Anatomy;Atlases;Behavior;cell type;Cells;Chromatin;chromatin modification;Collaborations;Communities;comparative;Data;data integration;Data Set;Development;Disease;DNA Methylation;Environment;Goals;Histologic;Human;Human BioMolecular Atlas Program;Human body;Human Resources;human tissue;Lead;Location;Maps;Measurement;Measures;Membrane Proteins;metabolic profile;Molecular;multimodality;multiple datasets;Process;Public Health;Resolution;Series;single cell technology;single-cell RNA sequencing;Statistical Methods;Tissues;tool;Work

PROJECT_TITLE: Comprehensive reference atlas construction, geolocation and data integration for HuBMAP HIVE [5 of 5]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: GAINESVILLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Public health significance: Brightfield histology imaging of tissues is inexpensive and commonly used by any clinical assessment all over the world. Our proposed tools will allow quantifying cell types, numbers, morphology, as well as states from brightfield histology images. Our success will empower clinicians anywhere in the world to deduce molecular understanding of single cells from brightfield tissue histology for clinical assessment.

PI_NAMEs: JAIN, SANJAY ;SARDER, PINAKI  (contact)

PROJECT_TERMS: 3-Dimensional;Anatomy;Atlases;Basic Science;Biological Models;Biology;Cell Count;cell type;Cells;Clinical assessments;clinical decision-making;clinical diagnosis;Clinical Research;computational pipelines;Computers;Data;data fusion;Data Set;Discipline;drug discovery;empowerment;Engineering;Environment;Genes;Goals;high dimensionality;Histology;Human;Image;Image Analysis;imaging modality;innovation;Internet;Knowledge;Link;Liver;Lung;lymph nodes;Machine Learning;machine learning pipeline;Maps;Mentorship;metabolome;Microscopy;Modeling;Molecular;molecular imaging;Morphology;Multiomic Data;next generation;novel;Ontology;Organ;Play;Plug-in;preclinical study;prognostication;Proteins;Public Health;recruit;Renaissance;Research Project Grants;Resolution;RNA;Scientist;Skin;submicron;success;synergism;Technology;Tissue imaging;Tissues;tool;Transcript;transcriptomics;Translational Research;underrepresented minority student;Validation

PROJECT_TITLE: A Computational IMage Analysis Platform (CIMAP) for HuBMAP


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Aging;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cerebrovascular;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: The mechanisms that link structural changes in the brain connectivity to the remapping of function after  stroke are unknown. Here we will define how synapses are impacted by stroke and determine the  synaptic mechanisms that underly the recovery of lost function in the mouse model of stroke. The results  of this work will provide mechanistic underpinnings of functional recovery after stroke and have the  potential to identify novel therapeutic targets that will lead to improvements of function in stroke patients.

PI_NAMEs: HRUSKA, MARTIN  (contact)

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: Architecture;Behavioral;Behavioral Paradigm;Brain;Centers of Research Excellence;Data;Dendritic Spines;DLG4 gene;Ephrin-B3;Exhibits;functional improvement;functional plasticity;Glutamate Receptor;hippocampal pyramidal neuron;Image;improved;Individual;insight;Knockout Mice;Link;Maps;Modification;Molecular;mouse model;N-Methylaspartate;nanoarchitecture;nanoscale;new therapeutic target;novel;old mice;Pathology;Phase;Play;post stroke;postsynaptic;presynaptic;prevent;Recovery;Recovery of Function;Research;Resolution;Role;scaffold;Sensorimotor functions;Signal Transduction;Site;Somatosensory Cortex;Stroke;stroke intervention;stroke model;stroke patient;stroke recovery;Synapses;Synaptic plasticity;Synaptic Transmission;Testing;two-photon;Universities;Vertebral column;West Virginia;Work

PROJECT_TITLE: Synaptic mechanisms of functional recovery after stroke


ADMINISTERING_IC: NS

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Gene Therapy;Genetics;Immunotherapy;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: LEBANON

ORG_NAME: CELDARA MEDICAL, LLC

ORG_STATE: NH

PHR: PROJECT NARRATIVE Amyotrophic lateral sclerosis (ALS) is a progressive nervous system disease that affects nerve cells in the brain and spinal cord causing loss of muscle control; ALS currently lacks effective options of treatment. Increased neuroinflammation is an important contributor to the progression of ALS which makes it an attractive therapeutic target. Our goal in this Fast Track application is to develop our novel CAR Treg therapeutic, CM-CS1, to reduce inflammation and damage to neurons in ALS, thus preventing disease progression and protecting neuronal survival and function.

PI_NAMEs: MURAD, JOANA M (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, FLOY ANNETTE

PROJECT_TERMS: Affect;Age of Onset;Age Years;ALS patients;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Anti-Inflammatory Agents;Antigens;Attenuated;autoinflammatory;Binding;Blood - brain barrier anatomy;Brain;Brain-Derived Neurotrophic Factor;Breeding;CD4 Positive T Lymphocytes;Cell Physiology;Cell Therapy;Cells;chimeric antigen receptor;Clinic;Clinical;Communities;Cytoplasmic Protein;Data;design;Development;Diagnosis;Disease;disease model;Disease Progression;effector T cell;engineered T cells;Engineering;Engraftment;Exclusion;extracellular;familial amyotrophic lateral sclerosis;Genetic Engineering;glial activation;Goals;Heredity;Homeostasis;Human;Immune;in vivo;Incidence;Individual;Inflammation;Injections;innovation;Interleukin-10;Life;Limb structure;Macrophage;manufacture;Mediating;Microglia;Modeling;motor neuron degeneration;Motor Neurons;mouse model;Mus;Muscular Atrophy;mutant;Mutation;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neuroinflammation;neuron loss;neuronal survival;Neurons;neuroprotection;novel;Oncology;Oxidative Stress;Paralysed;Parkinson Disease;Pathogenesis;Patients;Phase;Play;prevent;Progressive Disease;protein aggregation;Proteins;Regulatory T-Lymphocyte;Reporting;Risk;Role;Route;Sampling;Site;Spinal Cord;superoxide dismutase 1;T cell therapy;T-Lymphocyte;Therapeutic;Therapeutic Intervention;therapeutic target;therapeutically effective;Tissues;Toxicology;Transgenes;translational therapeutics;United States

PROJECT_TITLE: Development of CM-CS1 CAR Treg to Treat Amyotrophic Lateral Sclerosis (ALS)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-P(11)B]


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

ORG_CITY: DALLAS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative This project aims at defining mechanisms responsible for the formation and maintenance of the neuromuscular junction (NMJ), and the survival of motor neurons. This is important because abnormal formation or function of the NMJ, as well as the loss of motor neuron, is implicated in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). Therefore, identifying regulatory mechanisms responsible for structural and functional changes in the NMJ will enable us to improve current treatment strategies for neurodegenerative diseases such as ALS.

PI_NAMEs: LIN, WEICHUN  (contact);ROTHERMEL, BEVERLY A

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Acetylcholine;Acetylcholinesterase;Address;Alleles;Amyotrophic Lateral Sclerosis;Anabolism;autism spectrum disorder;Binding;Calcineurin;Cells;Central Nervous System;Choline Deficiency;Choline O-Acetyltransferase;Cholinergic Receptors;cholinergic synapse;Coupling;Cre driver;Cysteine-Rich Domain;Data;Defect;Development;Dihydropyridine Receptors;Elements;Embryo;Enzymes;Equilibrium;experimental study;Feedback;Foundations;Future;Gene Deletion;Gene Expression;Genes;Genetic;Genetic Transcription;Genomics;Goals;improved;insight;Investigation;Knowledge;Location;LoxP-flanked allele;Maintenance;Mediating;Mental Retardation;Modeling;Molecular;Motor;Motor Neurons;Mus;Muscle;Muscle Fibers;myocyte-specific enhancer-binding factor 2;Nerve;nerve supply;Neurodegenerative Disorders;Neurodevelopmental Disorder;neuromuscular;neuromuscular function;Neuromuscular Junction;neuron loss;neuronal survival;Neurons;Neurotransmitters;nuclear factors of activated T-cells;Pathway interactions;Pattern;Peripheral;Phenotype;Play;postnatal;postnatal development;postsynaptic;presynaptic;prevent;Prevention;Protein Isoforms;Protein phosphatase;Proteins;Proteomics;Regulation;Research Project Grants;Role;Ryanodine Receptor Calcium Release Channel;Schwann Cells;Shapes;Signal Pathway;Signal Transduction;Signaling Molecule;single nucleus RNA-sequencing;Site;Skeletal Muscle;Striated Muscles;Structure;Synapses;synaptogenesis;therapeutic development;therapeutically effective;tool;trafficking;transcription factor;Transgenic Mice;treatment strategy

PROJECT_TITLE: Patterning and Formation of the Neuromuscular Junction

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ORG_CITY: Aurora

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Narrative  We are proposing to develop an axon-specific bidirectional optical neural interface and test the system's efficacy to neuromodulate the parasympathetic nervous system by modulating heart function. We will use optogenetics and multiphoton optical excitation to simultaneously detect the neural activity and photostimulate individual axons from the exterior of the nerve i.e. an approach that is non-invasive yet has specificity. This technology has potential for major impact on the ability to treat many conditions; for example, vagal nerve stimulation in humans has been found to control epilepsy and depression, and evidence points to improvements in treatment of inflammatory bowel disease and Alzheimer's Disease.

PI_NAMEs: CALDWELL, JOHN H;GIBSON, EMILY ;WEIR, RICHARD FERGUS FFRENCH (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: 3-Dimensional;Abdomen;Action Potentials;Afferent Neurons;Alzheimer's Disease;Anesthesia procedures;Animals;awake;Axon;Behavior;Behavioral;Biomedical Research;Brain;Breathing;Calcium;calcium indicator;Cardiac;Cardiology;Cells;Cervical;Chest;Chronic;Clinical;clinical application;Collaborations;Communication;conditioned fear;Development;Devices;disability;Disease;Efferent Neurons;Electrocardiogram;Electrodes;Engineering;Epilepsy;Fascicle;FDA approved;flexibility;Future;Generations;Genetic Vectors;Glass;Goals;Grant;Heart;heart function;heart imaging;Heart Rate;Human;human disease;Image;Implant;implantation;improved;in vivo;Individual;Inflammatory Bowel Diseases;Injections;innovation;Lasers;lens;Lung;Measurement;Mechanics;Mental Depression;Metabolic Diseases;Methods;Microscope;Miniaturization;miniaturize;minimally invasive;Monitor;mouse model;multi-photon;multiphoton microscopy;Mus;Needles;Nerve;Nerve Tissue;neural;Neurons;neuroregulation;Neurosciences;new technology;novel;Opsin;Optic Nerve;Optics;optogenetics;Organ;Parasympathetic Nervous System;Pathway interactions;Penetration;Peripheral;Peripheral Nerves;Peripheral Nervous System;pharmacologic;Pharmacologic Substance;Physiologic pulse;Physiological;Polymers;portability;Property;Proteins;prototype;Publications;Reporter;Research;Research Personnel;Resolution;Scanning;side effect;Signal Transduction;Source;Specificity;stressor;System;Systems Integration;Tail;Techniques;Technology;Testing;Transgenic Mice;translation to humans;translational potential;two-photon;United States National Institutes of Health;Vagus nerve structure;Veins;Viral;Viral Vector;virtual;Virus;voltage;Work

PROJECT_TITLE: Optimization of a Minimally-Invasive Bidirectional Optogenetic Peripheral Nerve Interface with Single Axon Read-in & Read-out Specificity

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Complementary and Integrative Health;Dietary Supplements;Lung;Nutrition

ORG_CITY: FORT COLLINS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Chronic exposures to environmental dusts lead to lung inflammation, injury, and disease. The overarching goal of our studies is to determine how dietary omega-3 fatty acids promote resolution and repair in the lung following dust exposure through regulating macrophage-derived IL-22 signaling. These studies support NIH goals by increasing our understanding of how particulate matter inhalation impacts lung inflammation, and exploring strategies for promoting recovery from these inflammatory exposures to protect against disease.

PI_NAMEs: NORDGREN, TARA M (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: 3-Dimensional;Acids;Acute;aerosolized;Agriculture;Air;Air Pollution;Airway Disease;airway epithelium;airway inflammation;Alveolar;Alveolar Macrophages;Asthma;Attenuated;autocrine;Cells;Chronic;chronic inflammatory lung disease;chronic respiratory disease;Coculture Techniques;Data;desaturase;Diet;dietary;Disease;Disease Outcome;Docosahexaenoic Acids;Dust;Enzymes;epithelial repair;Epithelium;epithelium regeneration;evidence base;Exhibits;Exposure to;Farming environment;Fatty acid glycerol esters;Gene Expression Profiling;Genetic;Goals;Health;Immune;Immune signaling;Immunity;improved;in vivo;Inflammation;Inflammatory;Inhalation;Inhalation Exposure;injured airway;Injury;Intake;interleukin-22;Investigation;Knock-out;Knockout Mice;Knowledge;Lead;Leukotrienes;Link;lipid mediator;Lipids;Liquid substance;Lung;Lung Diseases;lung health;Lymphocyte;Macrophage;Macrophage Activation;Mediating;Mediator;Modeling;Molecular;Mucosal Immunity;Mus;nano-string;novel;novel therapeutic intervention;Omega-3 Fatty Acids;paracrine;Particulate;Particulate Matter;Pathway interactions;pharmacologic;Physiological;Pneumococcal Infections;Population;Predisposition;prevent;Production;Prostaglandins;protective effect;Publishing;pulmonary function decline;Pulmonary Inflammation;receptor;Receptor Signaling;Recommendation;Recovery;Regulation;repaired;Reporter;Research;resilience;Resolution;Respiratory Tract Infections;Risk;Role;rural environment;scaffold;Sepsis;Signal Transduction;Smoke;Source;STAT3 gene;Testing;Time;tissue repair;Tissues;Transgenic Mice;Translations;treatment strategy;United States National Institutes of Health;urban setting;western diet;Wildfire;YM1 doxorubicin analog

PROJECT_TITLE: Omega-3 fatty acids induce macrophage IL-22 signaling to promote resolution of dust-induced lung inflammation

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Data Science;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Patient Safety;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Prevention;Substance Misuse;Telehealth

ORG_CITY: BUEA

ORG_COUNTRY: CAMEROON

ORG_FIPS: CM

ORG_NAME: UNIVERSITY OF BUEA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will provide critical information on the mental health contribution to the burden of injury in low-and middle-income countries in general and Cameroon in particular, allowing to begin to understand the magnitude of this global health priority. The research is relevant to NIH’s mission because the application of the knowledge resulting from this research will contribute to enhance trauma patient’s health.

PI_NAMEs: CHICHOM, ALAIN MEFIRE (contact);JUILLARD, CATHERINE

PROGRAM_OFFICER_NAME: NEWSOME, BRAD

PROJECT_TERMS: acute care;acute stress;Affect;Africa;Africa South of the Sahara;African;alcohol use disorder;Anxiety;Area;Awareness;biological adaptation to stress;burden of illness;California;Cameroon;care systems;Caring;Cessation of life;clinical care;Collaborations;Communities;Community Health;Consolidated Framework for Implementation Research;contextual factors;Country;Coupled;Data;Data Science;Databases;demographics;Diagnosis;disability;Disease;Disparity;DSM-V;Early identification;Economics;effective intervention;Ensure;Equity;Failure;Feedback;follow-up;Follow-Up Studies;Foundations;Funding;Future;Generalized Anxiety Disorder;global health;Goals;Health;Health Personnel;Health Priorities;Healthcare;high risk;high risk population;Hospitals;implementation framework;Income;Individual;Inequity;information gathering;Infrastructure;injured;Injury;injury burden;Intervention;Knowledge;knowledge of results;Los Angeles;low and middle-income countries;mathematical sciences;Measures;Mental Depression;Mental Health;Methods;mHealth;mind/body;Mission;Mobile Health Application;Motivation;Operative Surgical Procedures;Outcome;Participant;Patient Discharge;patient population;patient screening;Patients;Perception;physically handicapped;Policies;poor health outcome;Population;Post-Traumatic Stress Disorders;Prevalence;programs;Protocols documentation;Psychiatric Hospitals;Public Health;Questionnaires;Registries;Research;Research Project Grants;Risk;Risk Factors;routine screening;screening;skills;South Africa;System;Testing;Trauma;Trauma patient;Traumatic injury;United States;United States National Institutes of Health;Universities;Update;Vulnerable Populations;Work

PROJECT_TITLE: Harnessing Data Science to Promote Equity in Injury and Surgery for Africa

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(70)-R]


NIH_SPENDING_CATS: Clinical Research;Data Science;Dissemination and Implementation Research;Emergency Care;Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention

PHR: Project Narrative The proposed research is relevant to public health because development of a smartphone application capable of mapping injury aims to fill a critical deficit needed to support prehospital development. If found to be feasible, this approach would create essential capacity in this context. The research is relevant to NIH’s mission because it seeks to lengthen the lives of trauma patients.

PI_NAMEs: CHICHOM, ALAIN MEFIRE (contact);CHRISTIE, SABRINAH ARIANE

PROJECT_TERMS: acceptability and feasibility;acute care;Address;Africa;African;Air;Area;burden of illness;California;Cameroon;care systems;Caring;Cellular Phone;Cessation of life;clinical care;Collaborations;Communities;Community Health;Country;crowdsourcing;Data;Data Analyses;Data Collection;data management;data repository;Data Science;demographics;design;Development;Discrimination;Disease;Disparity;Emergency Situation;Equity;Event;follow-up;Funding;Future;Goals;Heart;High School Student;Hospital Planning;Hospitals;Image;implementation facilitators;implementation science;Improve Access;improved;Inequity;Infrastructure;injured;Injury;injury burden;injury prevention;injury-related death;Intervention;Interview;Location;Los Angeles;low and middle-income countries;Maps;mathematical sciences;member;Mission;Modeling;Morbidity - disease rate;mortality;Operative Surgical Procedures;Outcome;Participant;Patients;Performance;Policy Maker;Population;Pre-hospitalization care;prevent;preventable death;Prevention strategy;prototype;Public Health;recruit;Registries;Reporting;Research;Research Project Grants;Resource Allocation;Resources;smartphone application;South Africa;Structure;Surveys;System;Technology;Testing;Trauma;trauma care;Trauma patient;Triage;United States National Institutes of Health;Universities;usability;Validation;Work


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;HIV/AIDS;Human Genome;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PI_NAMEs: GALE, MICHAEL  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;adaptive immune response;AIDS Vaccines;Algorithms;biocomputing;Bioinformatics;Biological Assay;Cellular Immunology;Contractor;Contracts;Data;design;Enrollment;Ensure;functional genomics;genetic signature;Genomic approach;Genomics;Immune response;Immunologic Tests;Immunologics;Immunology;improved;Infection prevention;Innate Immune Response;Laboratories;Methods;Modeling;National Institute of Allergy and Infectious Disease;nonhuman primate;pre-clinical;Protocols documentation;Research Personnel;response;RNA;Sampling;Services;Site;Standardization;Testing;tool;transcriptomics;vaccine development;vaccine efficacy;vaccine evaluation;Vaccine Research;Vaccines;Viral;Virus;Virus Replication

PROJECT_TITLE: Nonhuman Primate (NHP) Core Functional Genomics Laboratory for AIDS Vaccine Research and Development


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: HARARE

ORG_COUNTRY: ZIMBABWE

ORG_FIPS: ZI

ORG_NAME: CENTRE/SEXUAL HLTH/HIV AID RES/ZIMBABWE

PHR: Narrative Landscape fire smoke and birth outcomes in sub-Saharan Africa Africa is the continent that experiences the most landscape fires in the world. There is emerging evidence that if pregnant women are exposed to smoke from these fires, their babies are likely to be born smaller than normal, or earlier than usual. However, most of this evidence has been generated from studies done in the USA and in Brazil. This proposed research will test these assumption in sub-Saharan Africa. We will make use of data on the birth outcomes from some of the data that is being assembled as part of the NIH funded HE2AT center. The project will leverage and complement the CHEAQI-MNCH project that is asking similar question on other pollution exposures and their effect on the pregnancy outcomes for mothers and their babies.

PI_NAMEs: GOVINDASAMY, TAMARA ;MAKANGA, PRESTIGE TATENDA (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: Accounting;adverse birth outcomes;Affect;Africa;Africa South of the Sahara;Agriculture;Air;Air Pollution;Area;Birth;Birth Weight;Body Weight decreased;Brazil;Burn injury;Child;Child Health;cohort;Complement;Country;Data;data infrastructure;Databases;experience;Exposure to;federated data;fine particles;Fire - disasters;Funding;Future;Heterogeneity;Income;Low Birth Weight Infant;Maternal Health;maternal outcome;Meta-Analysis;Methods;Morbidity - disease rate;mortality;neonatal health;Outcome;Pollution;Pregnancy;Pregnancy Outcome;Pregnant Women;Premature Birth;Research;Research Project Grants;Risk;Smoke;synergism;Testing;United States;United States National Institutes of Health;Wildfire

PROJECT_TITLE: Landscape fire smoke and birth outcomes in Sub Saharan Africa


NIH_SPENDING_CATS: Bioengineering;Climate-Related Exposures and Conditions;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Social Determinants of Health

ORG_CITY: PARKTOWN

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: WITS HEALTH CONSORTIUM (PTY), LTD

PHR: Project Narrative The HarmonAIze project will deliver a generalizable, semi-automated toolkit to aid health data harmonization and linkage with climate data using novel AI approaches, thereby addressing key barriers to the large-scale re- analysis of health data across all research topics, and markedly accelerating progress in the field of climate and health. We will accelerate and extend the achievement of the HE2AT Center and DS-I Africa’s objectives, by building data science and leadership capacity in early-career investigators, supported by a mentorship network within the HE2AT Center consortium. Sharing the open-source toolkit through the eLwazi Open Data Science Platform, and piloting implementation of the kit within other DS-I Africa Research Hubs, will maximize impact within the DS-I Africa consortium, and advance public health research more broadly.

PI_NAMEs: CHERSICH, MATTHEW FRANCIS (contact);LUCHTERS, STANLEY

PROJECT_TERMS: absorption;Acceleration;Achievement;Address;Africa;African;Artificial Intelligence;Black Box;career;Climate;climate change;climate data;climate science;climate-related exposures;climate-related health;Collaborations;Communicable Diseases;Communities;Computer software;Critical Pathways;Data;data harmonization;data integration;Data Linkages;data preservation;data privacy;data reuse;Data Science;Data Set;data sharing;Databases;design;Development;digital solutions;diverse data;Educational workshop;Effectiveness;empowerment;Engineering;Ensure;Environment;experience;FAIR principles;Fostering;Future;Generations;global health;Goals;Health;health data;Health Policy;heterogenous data;human-in-the-loop;improved;innovation;interdisciplinary collaboration;Intervention;large language model;Leadership;life span;Machine Learning;Manuals;Mentors;Mentorship;Metadata;Methods;Modeling;Non-linear Models;novel;Ontology;open data;open source tool;Pathway interactions;Pilot Projects;Policy Making;privacy preservation;Process;programs;Public Health;public health research;remote sensing;Research;Research Personnel;Resources;response;Retrieval;Role;scaffold;Scientist;Secure;skills;Source;spatiotemporal;Specialist;Standardization;synthetic data;Technology;Time;tool;Training;Training Programs

PROJECT_TITLE: The HarmonAIze Project: Pioneering Automated Climate and Health Data Harmonization and Integration


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The restructured UCSF-Bay Area CFAR is dedicated to promoting multidisciplinary research addressing cutting-edge questions in HIV/AIDS biology, treatment, and prevention. This approach from UCSF has led to breakthrough discoveries advancing patient care and providing new approaches to curbing the HIV pandemic both locally and internationally. CFAR is also committed to supporting the next generation of HIV researchers, international research, health equity, and community engagement, all of which are critical for truly ending the HIV epidemic.

PI_NAMEs: GANDHI, MONICA  (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Advocacy;Area;Basic Science;Behavior;Behavioral Research;biobehavior;Bioinformatics;Biological Markers;Biological Specimen Banks;Biology;Biometry;career;career development;Cities;Clinic;Clinical;clinical care;Clinical Research;co-infection;cohort;Collaborations;Communication;Communities;community engagement;comorbidity;computerized data processing;Dedications;Development;Educational workshop;Epidemic;Evaluation;Event;experience;Fostering;Foundations;functional genomics;Goals;Grant;health equity;HIV;HIV/AIDS;Housing;Immunology;implementation science;improved;Inflammation;Infusion procedures;innovation;Institution;Interdisciplinary Study;International;intersectionality;Laboratories;Leadership;Measures;meetings;Mentors;Methods;minority investigator;Monitor;multidimensional data;multidisciplinary;Multiomic Data;Names;National Institute of Allergy and Infectious Disease;next generation;novel;novel strategies;Outcome;pandemic disease;Participant;Pathogenesis;Patient Care;Pharmacology;Positioning Attribute;pre-exposure prophylaxis;Prevention;Productivity;programs;Prospective cohort;referral services;Research;Research Personnel;Resources;response;Risk;social;Specimen Handling;structural determinants;structural health determinants;substance use;Training;Translational Research;Underrepresented Minority;United States National Institutes of Health;Visualization;Vulnerable Populations;ward;Work;working group

PROJECT_TITLE: UCSF-Bay Area Center for AIDS Research


NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homelessness;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

PI_NAMEs: RILEY, ELISE D. (contact)

PROJECT_TERMS: Academia;Acceleration;Acquired Immunodeficiency Syndrome;Address;Advocate;AIDS prevention;Area;barrier to testing;biobehavior;California;career development;Caring;Case Management;Collaborations;Communities;community engagement;Community of Practice;community partners;comorbidity;Country;Development;Director's Working Group;Discipline;Disparity;Doctor of Philosophy;Educational workshop;Environment;Epidemic;Event;experience;Failure;food insecurity;Fostering;Funding Opportunities;Goals;Health;health care delivery;health equity;Healthcare;HIV;HIV diagnosis;HIV disparities;HIV Infections;Homelessness;Housing;housing instability;implementation science;Imprisonment;improved;Incidence;Individual;Inequity;insight;Interdisciplinary Study;Interest Group;International;intersectionality;Intervention;Investigation;knowledge base;Link;Low Income Population;marginally housed;member;Mental Depression;Mentors;Methodology;migration;Mission;multidisciplinary;next generation;novel;novel strategies;Outcome;Persons;Policy Maker;Population;Post-Traumatic Stress Disorders;pre-exposure prophylaxis;Prevention;Primary Care;programs;Public Health;racism;Research;Research Personnel;Research Project Grants;response;Risk;Risk Factors;San Francisco;Science;Services;severe mental illness;social;social stigma;substance use;symposium;synergism;Testing;Training;Treatment outcome;uptake;Violence;Viral;Viral Load result;Woman;Work;working group

PROJECT_TITLE: Housing Scientific Working Group


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Immunotherapy;Ovarian Cancer;Rare Diseases;Uterine Cancer;Women's Health Research

ORG_CITY: Pittsburgh

ORG_NAME: MAGEE-WOMEN'S RES INST AND FOUNDATION

ORG_STATE: PA

PHR: The uterine serous cancer (USC) tumor microenviroment is characterized by large numbers of immunosuppressive myeloid cells that might reduce the effectiveness of current immunotherapies. Our data suggest that Egfl6, a protein secreted by tumor cells, induces the activaction of Syk factor in myeloid cells promoting their immunosuppressive phenotype. In this study, we will determine the role of Egfl6/Syk axis in USC and evaluate the efficacy of Egfl6 and/or Syk inhibition as an adjuvant to immunotherapy.

PI_NAMEs: CASCIO, SANDRA  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: adaptive immune response;Adjuvant;Adjuvant Chemotherapy;anti-tumor immune response;Biology;Black race;black women;Bone Marrow;cancer cell;cancer type;Carcinoma;CD8-Positive T-Lymphocytes;Cells;Cessation of life;Classification;Collaborations;Combination immunotherapy;Combined Modality Therapy;Data;Development;Disease;Effectiveness;efficacy evaluation;EGF-Like Domain;Endometrial Carcinoma;Gene Expression Profiling;Genomics;granulocyte;Gynecologic Oncologist;Human;Immune;immunoregulation;Immunosuppression;Immunotherapy;improved;Incidence;Infiltration;inhibitor;Innate Immune Response;interest;Macrophage;Malignant neoplasm of ovary;Malignant Neoplasms;Molecular;mouse model;Mus;Mutate;Myeloid Cells;Myeloid-derived suppressor cells;neoplastic cell;neutralizing antibody;Operative Surgical Procedures;overexpression;Pathologist;Patients;Phenotype;Prognostic Factor;programmed cell death ligand 1;Prospective Studies;Recombinant Proteins;recruit;response;Retrospective Studies;Role;Sampling;Serous;Signal Transduction;single-cell RNA sequencing;Spatial Distribution;Specimen;standard of care;success;Survival Rate;SYK gene;T-Lymphocyte;Testing;Therapeutic;Tissue Sample;Tissues;TP53 gene;trafficking;Transgenic Mice;treatment strategy;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor-associated macrophages;tumor-immune system interactions;Tumor-infiltrating immune cells;Tumor-Secreted Protein;tumorigenic;Uterine Cancer;Uterus;White Women;Work

PROJECT_TITLE: The Role of Egfl6 in Tumor Immunity


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Disability Research;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention;Rehabilitation

ORG_CITY: SAINT LOUIS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Cognitive decline in Parkinson disease (PD) causes disability and reduced quality of life. Current medical treatments do not prevent or treat cognitive decline in PD, so behavioral interventions that mitigate its negative functional consequences and thus potentially delay the onset of dementia are in high demand. This study will test the efficacy of a targeted training approach for improving cognition and daily function in people with PD and may ultimately result in enhanced independence and quality of life for this population.

PI_NAMEs: FOSTER, ERIN  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Address;Alzheimer's disease related dementia;behavior prediction;Behavior Therapy;Brain Injuries;Cognition;Cognitive;Cognitive deficits;cognitive function;cognitive impairment in Parkinson's;cognitive rehabilitation;coping;daily functioning;Data;Dementia;design;disability;Educational Intervention;Educational process of instructing;efficacy evaluation;efficacy testing;Employment;Functional impairment;Future;Goals;Health behavior;Health Care Costs;Impaired cognition;improved;Independent Living;Infrastructure;Intervention;Intervention Studies;Laboratories;Longitudinal cohort;Medical;member;Memory impairment;mortality;neural;neurobiological mechanism;neuromechanism;novel;Parkinson Disease;Parkinson's Dementia;Participant;Performance;Persons;Population;Populations at Risk;Prediction of Response to Therapy;Process;prospective memory;Quality of life;Randomized, Controlled Trials;repetitive task practice;Reporting;Research;Research Personnel;Research Priority;response;Single-Blind Study;social relationships;Stroke;Training;trial comparing;Work

PROJECT_TITLE: Prospective memory impairment in Parkinson disease-related cognitive decline: Intervention and mechanisms

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cannabinoid Research;Chronic Pain;Drug Abuse (NIDA only);Genetics;Neurodegenerative;Neurosciences;Opioids;Pain Research;Peripheral Neuropathy;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Project Narrative Here we propose to test the central hypothesis that REST in DRG neurons is involved in regulating opioid analgesia in chronic neuropathic pain and in chronic opioid-induced hyperalgesia /analgesic tolerance by governing opioid receptors and cannabinoid receptor expression through epigenomic regulation of these genes. Thus, manipulation of REST in DRG neurons could be utilized to increase opioid analgesic efficacy and reduce opioid consumption. The project is responsive to PAR-18-742.

PI_NAMEs: MAJUMDER, SADHAN  (contact);PAN, HUI-LIN

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: addiction;Affect;Afferent Neurons;Agonist;American;Analgesics;antagonist;Antibodies;Attenuated;Binding;cannabinoid receptor;Chromatin;chromatin modification;Chromatin Remodeling Factor;Chronic;chronic neuropathic pain;chronic pain;Clinical;Complex;conditional knockout;Disease;DNA Methylation;DNA-Directed RNA Polymerase;Epigenetic Process;epigenomics;Exhibits;experimental study;FDA approved;Female;G9a histone methyltransferase;gain of function;gender difference;Gene Expression Regulation;Genes;genetic corepressor;genetic inhibitor;Genetic Transcription;Goals;Histones;Hyperalgesia;Hypersensitivity;inhibitor;innovation;insight;Knockout Mice;Link;loss of function;Maintenance;male;Mediating;MicroRNAs;mouse model;Mus;nerve injury;Nervous System;Neurons;nociceptin;novel;Opioid;Opioid Analgesics;opioid epidemic;Opioid Receptor;opioid use;overexpression;Pain;pain chronification;Peripheral nerve injury;Pharmaceutical Preparations;Printing;Process;Promoter Regions;receptor;receptor expression;Receptor Gene;Regulation;Repression;Rest;Role;Sertraline;Signal Transduction;Site;Small Interfering RNA;somatosensory;Spinal Ganglia;System;Testing;Transcription Repressor;United States National Institutes of Health;Untranslated RNA;VP 16;Wild Type Mouse;Work

PROJECT_TITLE: REST-mediated regulation of opioid receptors in chronic pain mouse models


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Hearing Loss;Pediatric;Prevention;Rehabilitation

ORG_CITY: BOYS TOWN

ORG_NAME: FATHER FLANAGAN'S BOYS' HOME

ORG_STATE: NE

PHR: PROJECT NARRATIVE  Patients with hearing loss who use cochlear implants (CIs) show significant deficits and strong unexplained intersubject variability in their perception and production of spoken emotions in speech. This project will investigate the hypothesis that “cue-weighting”, or how patients utilize the different acoustic cues to emotion, accounts for significant variance in emotional communication with CIs. The results will focus on children with CIs, but parallel measures in postlingually deaf adults with CIs will be made, ensuring that results of these studies benefit social communication by CI patients across the lifespan by informing the development of technological innovations and improved clinical protocols.

PI_NAMEs: CHATTERJEE, MONITA  (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TITLE: Perception and Production of Emotional Prosody with Cochlear Implants

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences

ORG_CITY: CARLSBAD

ORG_NAME: BIOSPYDER TECHNOLOGIES, INC.

ORG_STATE: CA

PHR: NARRATIVE Phase I data demonstrates the feasibility of producing a gene expression-based assay for the highly accurate classification of patients with Alzheimer’s Disease and other dementias using a sample of blood spotted on filter paper which is easy to collect in the doctor’s office, clinic, or even by self-collection. The validation of this assay in Phase II with multiple cohorts of samples, correlation to FDA-approved tests, and use to elucidate potential novel therapeutic targets and the launch of RUO whole transcriptome, Alzheimer’s, and pan- dementias tests will be transformative for the field of neurodegenerative diseases at the levels of basic research, translational research, and drug discovery and development, as will the subsequent development into a definitive Alzheimer’s or pan-dementia diagnostic assay. By enabling self-collection, this test may also reduce health disparities and transform the diagnosis of Alzheimer’s Disease and other dementias to permit neurologists to focus on confirmation and treatment rather than diagnosis.

PI_NAMEs: SELIGMANN, BRUCE E. (contact)

PROGRAM_OFFICER_NAME: RADOJA, NADEZDA

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease diagnostic;Alzheimer's disease patient;Alzheimer's disease test;American;Amyloid;Archives;Basic Science;Bioinformatics;Biological Assay;Biological Markers;Black American;Blood;Blood Cells;blood filter;Blood specimen;Breakthrough device;Caring;Cells;Cerebrospinal Fluid;chronic traumatic encephalopathy;Classification;Clinic;cognitive testing;cohort;Collection;commercialization;companion diagnostics;Confidential Information;cost;Data;Dementia;Dementia with Lewy Bodies;design;Development;Diagnosis;diagnostic assay;Diagnostic Reagent Kits;Diagnostic tests;drug development;drug discovery;Early Diagnosis;Early identification;experience;Family;Family member;FDA approved;Fingers;Freezing;Frontotemporal Dementia;Future;Gene Expression;Gene Expression Profiling;Grant;health assessment;health care availability;health disparity;Hispanic Americans;Huntington Disease;Immune;Immunoassay;improved;in-vitro diagnostics;innovation;Insurance;Ligase;Ligation;Longitudinal cohort;Marketing;Measures;meetings;men;mild cognitive impairment;Minority;molecular phenotype;Multi-Infarct Dementia;Neurodegenerative Disorders;Neurologist;new therapeutic target;Not Hispanic or Latino;novel;Paper;Parkinson Disease;Pathogenesis;Pathway interactions;Patients;Performance;Persons;Phase;Physicians;Plasma;Population;Positron-Emission Tomography;Prevalence;programs;protein biomarkers;Protocols documentation;Reduce health disparities;research clinical testing;Risk;Role;sample collection;Sampling;Sensitivity and Specificity;Specificity;Spottings;Testing;Therapeutic Intervention;therapeutic target;Time;Training;transcriptome;Translational Research;Traumatic Brain Injury;Uncertainty;Validation;Whole Blood;Woman

PROJECT_TITLE: Whole blood filter paper assay for Alzheimers Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-G(13)B]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: PITTSBURGH

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Narrative Dr. Corina Bondi is a tenured Associate Professor in the Departments of Physical Medicine and Rehabilitation and Neurobiology, and a member of the training faculty in the Center for Neuroscience at the University of Pittsburgh. Her R01 parent grant (R01NS110609) aims to assess cognitive- and anxiety-like dimensions sensitive to both traumatic brain injury (TBI) and aging, as the elderly represent a high risk population for both cognitive decline and TBI incidence, and to address mechanistic questions regarding altered cholinergic neurotransmission responsible for such deficits. In 2024, Dr. Bondi was awarded the NINDS Landis Award for Outstanding Mentorship to supplement training-related activities, and it will be used to ensure the salaries of a postdoc for 4 months, a postbaccalaureate trainee for one year, as well as for research supplies for the URM undergraduate supplementee on the R01 and a medical student, travel for 8 mentees to conferences, publication costs for my trainees, and a portable computer for training purposes (papers, talks, posters, etc).

PI_NAMEs: BONDI, CORINA OANA (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Address;aged;Aging;Anxiety;Award;Behavioral;cholinergic;Cholinergic Receptors;Cognitive;Computers;cost;Data Analyses;Dimensions;Elderly;Ensure;environmental enrichment for laboratory animals;executive function;experimental study;Faculty;Female;Funding;graduate student;high risk population;Impaired cognition;Incidence;International;male;Manuscripts;Medical Students;member;Mentorship;Mexican Americans;mid-career faculty;National Institute of Neurological Disorders and Stroke;Native Americans;Nervous System Trauma;neurobehavioral;Neurobiology;Neurosciences;neurotransmission;Paper;parent grant;parent project;Parents;Performance;Physical Medicine;Physical Rehabilitation;Pilot Projects;portability;positive allosteric modulator;Postbaccalaureate;Postdoctoral Fellow;posters;Publications;Puerto Rico;Rattus;Research;Science;Societies;summer student;sustained attention;symposium;System;Teacher Professional Development;Training;Traumatic Brain Injury;Travel;undergraduate student;Universities;Wages;Work;young adult

PROJECT_TITLE: Traumatic brain injury and aging: targeting the cholinergic system for deficits in sustained attention and executive function


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Health Services;Precision Medicine

ORG_CITY: EAST LANSING

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

ORG_STATE: MI

PI_NAMEs: AHMEDANI, BRIAN KENNETH;JOHNSON, CHRISTINE C ;PELTZ, CATHRYN  (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, IRENE

PROJECT_TERMS: Acceleration;Achievement;Address;Adult;Age;aged;Aging;All of Us Research Program;Area;Asthma;Authorization documentation;Award;Back;Baseline Surveys;Behavioral;Big Data;Big Data Methods;biobank;Biological Markers;Biomedical Research;Cancer Research Network;Cardiovascular Diseases;Caring;case control;Cells;Cellular Phone;Child;chronic pain;Clinic;Clinical;Clinical Trials;Clinical Trials Network;Cloud Computing;cohort;Collaborations;Communication;community engagement;Community Networks;Community Outreach;Consent;cost;Data;data access;data platform;data streams;Databases;Dedications;Dementia;design;Development;Devices;Diabetes Mellitus;Diagnosis;Diagnostic;Disease;disease classification;Electronic Health Record;electronic health record system;Enrollment;Ensure;Epidemiology;epidemiology study;Ethics;Ethnic Origin;Evolution;experience;Explosion;follow-up;Fostering;Funding;General Population;Genetic;Genetic Research;Genomics;Geographic Locations;Geography;Geriatrics;Goals;Health;Health Personnel;health plan;Health Services;Health system;Healthcare;Healthcare Systems;Human;Human Resources;Hypersensitivity;Idaho;improved;Individual;individual patient;Informatics;Infrastructure;Institution;Institutional Review Boards;Internet;Intervention;Lead;male;Malignant Neoplasms;Massachusetts;Measurement;Measures;Medicaid;Medical;Medical Research;Medicare;Medicine;meetings;Mental Health;Methods;Michigan;Midwestern United States;Minnesota;Mission;Modeling;Modification;Monitor;Movement;multi-site trial;National Institute of Drug Abuse;National Institute of Mental Health;North Dakota;Nurses;Obesity;outreach;outreach program;Participant;participant enrollment;patient engagement;patient oriented;patient outreach;patient population;patient retention;Patient Self-Report;Patients;Pattern;Pediatric Hospitals;Pediatrics;Performance;Philosophy;Population;Population Heterogeneity;post-pandemic;Precision Health;precision medicine;preference;Preventive;Preventive measure;Process;process improvement;Program Sustainability;programs;prospective;Prospective Studies;Public Health;Public Health Informatics;Publications;Race;Recording of previous events;recruit;Research;Research Design;Research Personnel;Research Project Grants;research study;Research Training;Resources;Sample Size;Sampling;Science;Scientist;Sentinel;Site;social;social health determinants;Specialist;Subgroup;substance use;Surveys;System;systems research;Texas;therapy design;Time;tool;Underrepresented Populations;United States National Institutes of Health;Universities;Variant;Veterans;volunteer;wearable device;wireless;Wisconsin;Work;Writing

PROJECT_TITLE: All of Us Research Program Trans-America Consortium of the HCSRN


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Clinical Research;Dietary Supplements;Endocrine Disruptors;Estrogen;Lead Poisoning;Menopause;Nutrition;Obesity;Osteoporosis;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: NARRATIVE Healthy bone is critical for long term health not only to minimize fracture risk and related morbidity and mortality, but as an endocrine organ with influence on energy homeostasis, mineral metabolism, and adiposity. The goal of this longitudinal study is to investigate phthalate and metals exposure across two sensitive life stages – pregnancy and peri-menopause – in relation to bone health in midlife. Findings from this work will provide insight into mechanisms of exposure-related changes in bone health, with important implications for osteoporosis, fracture risk, and metabolic and cardiovascular health, as well as identify modifiable risk factors for these significant adverse health outcomes.

PI_NAMEs: TAMAYO-ORTIZ, MARCELA ;WATKINS, DEBORAH J (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: Acceleration;Adipocytes;Adipose tissue;Affect;Age Years;Alkaline Phosphatase;Biological;Biological Markers;Birth;blood lead;blood Pb concentration;Body Composition;Body mass index;bone;Bone Density;bone health;bone loss;Bone Matrix;bone metabolism;Bone remodeling;Bone structure;Cadmium;calcium supplementation;Cardiovascular Diseases;cardiovascular health;Cells;Chemicals;cohort;Collaborations;directed differentiation;Drug or chemical Tissue Distribution;Dual-Energy X-Ray Absorptiometry;early life exposure;Elderly;Endocrine;Endocrine Disruptors;Endocrine Glands;Environmental Epidemiology;Environmental Pollutants;Exposure to;Femur;fibroblast growth factor 23;follow-up;Fracture;fracture risk;Future;Goals;Gonadal Steroid Hormones;Health;Health Policy;Heavy Metals;Hip region structure;Homeostasis;Hormones;Human;indexing;Individual;insight;Insulin Resistance;Lead;lead exposure;Life;Long-Term Effects;Longitudinal Studies;Measures;Menopausal Status;Mesenchymal Stem Cells;Metabolic;Metabolism;Metal exposure;Metals;Mexico;middle age;Minerals;modifiable risk;Morbidity - disease rate;mortality;Mothers;Mus;Muscle;National Health and Nutrition Examination Survey;Nutrient;Obesity;Osteoblasts;Osteogenesis;Osteoporosis;Outcome;Participant;Pathway interactions;Perimenopause;perinatal period;personal care products;phthalates;Plastics;Population;Postmenopause;postnatal;Postpartum Period;PPAR gamma;Pregnancy;prenatal;prenatal exposure;preventive intervention;Public Health;quantitative ultrasound;randomized trial;Recording of previous events;Recovery;recruit;Reporting;Research;Risk;Risk Factors;Sampling;Serum;Skeletal Muscle;sound;Speed;Spinal;Statistical Methods;Structure;Toxic Environmental Substances;urinary;Vertebral column;Visit;Vitamin D;Woman;Work

PROJECT_TITLE: Relating phthalate and metals exposure during pregnancy and perimenopause to bone health and body composition in midlife


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Gene delivery using adeno-associated virus vectors has tremendous potential as treatment for congenital and acquired diseases of the nervous system. Understanding viral vector dynamics is key to optimizing drug design and has been hampered by a lack of means to resolve nanoscale viral particles in living tissues. This proposal seeks to develop efficient super-resolution imaging tools to improve imaging of adeno-associated viral vector trafficking in live animal models to advance understanding of viral vector bgene delivery.

PI_NAMEs: COTO HERNANDEZ, IVAN  (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: 3-Dimensional;Acoustics;adeno-associated viral vector;Afferent Neurons;Anesthesia procedures;Animal Model;Axon;Back;biomedical imaging;Biomedical Research;Biotechnology;Capsid;cell type;Cells;cellular transduction;Central Nervous System;Cognition;Complex;Computer software;Cornea;cost;Dependovirus;design;Development;Dimensions;Disease;Drug Design;Dyes;Electron Microscopy;Emotions;Engineering;expectation;Fiber;Gene Delivery;Goals;Image;Image Enhancement;Imaging Device;imaging platform;Imaging Techniques;improved;In Vitro;in vivo;insight;intravital imaging;Knowledge Discovery;Label;Lasers;lens;Life;Light;light microscopy;Liquid substance;Mentors;Microscope;Microscopy;multi-photon;multiphoton microscopy;Mus;nanoscale;Nervous System;Nervous System Disorder;nervous system imaging;Neurons;novel;Nuclear Translocation;open source;Optics;Organism;Output;particle;Pattern;Penetration;Peripheral Nervous System;permissiveness;Physics;Physiologic pulse;Positioning Attribute;Process;Resolution;Resources;Schwann Cells;Sensorimotor functions;Sensory;Shapes;Signal Transduction;skills;Source;spatiotemporal;Specimen;Speed;Spinal Ganglia;Stretching;Structure;superresolution imaging;Techniques;Therapeutic;Thick;Time;Tissues;trafficking;two-photon;ultra high resolution;uptake;vector;Venus;Viral;Viral Vector;Virion;virology;Visualization;Work

PROJECT_TITLE: Super-resolved multiphoton microscopy with dual output ultrafast laser


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Transplantation

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: Project Narrative  Extremity trauma involving volumetric muscle loss (VML) presents a clinical challenge with significant fibrosis and fatty infiltration, impaired regeneration, and long-term functional disabilities. In this work, we will use pre-clinical models to define the roles of key cell types in the pathologic process of VML. We then utilize this foundational understanding to develop newly engineered immunomodulatory and regenerative treatment strategies with the long term goal of translating these into clinical treatments to improve functional outcomes after VML injuries.

PI_NAMEs: WILLETT, NICK J (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Adipose tissue;analytical method;Animals;Attenuated;Autologous Transplantation;Biocompatible Materials;Cell Count;Cell Differentiation process;Cell Lineage;Cell Physiology;Cell Proliferation;Cell Transplantation;cell type;Cells;Characteristics;Chronic;chronic pain;Clinical;Clinical Treatment;Coculture Techniques;controlled release;CXCR4 gene;Cytometry;Data;Defect;Development;directed differentiation;Encapsulated;Engineering;Engraftment;Environment;experimental study;Fibrosis;Foundations;functional disability;functional improvement;functional outcomes;Functional Regeneration;Gait;General Population;Goals;healing;Histology;Hydrogels;Immune;immunoengineering;immunomodulatory therapies;immunoregulation;Impairment;In Vitro;in vivo;Infiltration;Inflammation;Injury;Integrins;Interleukin-10;Interleukin-4;Isometric Exercise;Lead;limb injury;lipid mediator;Liposomes;Macrophage;Maleimides;mesenchymal stromal cell;Military Personnel;Modeling;Molecular;monocyte;Mus;Muscle;muscle engineering;Muscle Fibers;muscle progenitor cell;muscle regeneration;Muscle satellite cell;Muscular Dystrophies;Myeloid Cells;myogenesis;Natural regeneration;novel;novel therapeutic intervention;Operative Surgical Procedures;Outcome;Pathologic Processes;Pathology;Phenotype;Play;Polyethylene Glycols;pre-clinical;Pre-Clinical Model;Process;Production;Profibrotic signal;Proliferating;Publications;quadriceps muscle;Recovery of Function;regeneration potential;regenerative;regenerative treatment;repaired;response;Role;Saline;scaffold;Series;Signal Transduction;Sorting;stem cell function;stem cell niche;stem cell proliferation;Stem cell transplant;stem cells;System;Testing;Thick;Time;Tissue Engineering;Tissues;Torque;Transgenic Animals;Translating;Transplantation;Treatment Efficacy;treatment strategy;volumetric muscle loss;Work

PROJECT_TITLE: Engineering the Immune and Fibrotic Response in Volumetric Muscle Loss

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: IRVINE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative: The proposed research aims to develop innovative technologies to image the brains of unborn babies in utero, and to apply those techniques to study the development of brain function before birth. The technology developed, and the knowledge gained in this study, is expected to guide early treatments and therapeutic interventions to improve neurodevelopmental outcomes in high-risk babies or babies with congenital disorders.

PI_NAMEs: GHOLIPOUR-BABOLI, ALI  (contact)

PROGRAM_OFFICER_NAME: SANTOS SCHMIDT, AUGUSTO FREDERICO

PROJECT_TERMS: Address;Adolescent;Adult;Affect;Algorithms;analysis pipeline;Anatomy;Atlases;Back;Basal Ganglia;Birth;Brain;Brain Hypoxia-Ischemia;Brain imaging;Child;Circulation;Cognitive deficits;cohort;Common Ventricle;Communication;Compensation;congenital brain disorder;Congenital Disorders;congenital heart abnormality;Data;data imputation;Development;Developmental Delay Disorders;Disease;Dropout;Early treatment;Ensure;fetal;Fetal Development;Fetus;Functional Magnetic Resonance Imaging;functional MRI scan;Goals;Head;Heart Diseases;high risk;Human;Hypoxia;Image;image processing;Imaging technology;Impairment;improved;in utero;in vivo;independent component analysis;Infant;innovation;innovative technologies;Knowledge;Lead;Life;Magnetic Resonance Imaging;Mental disorders;Methods;migration;Motion;neural;neural circuit;neurodevelopment;Neurodevelopmental Disorder;Neurology;Neurons;Neurosciences;Organ;Outcome;Patients;Pregnancy;prenatal;Prevention strategy;Process;prospective;real-time images;reconstruction;Reference Standards;Reporting;Research;Resources;Sample Size;Sampling;Scanning;School-Age Population;Second Pregnancy Trimester;Series;Signal Transduction;Single ventricle congenital heart disease;Slice;Structure;success;synaptogenesis;Techniques;Technology;temporal measurement;Testing;Therapeutic Intervention;Time;tool;Work

PROJECT_TITLE: Imaging early development of human neural circuits

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Orphan Drug;Ovarian Cancer;Rare Diseases;Uterine Cancer;Women's Health Research

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Project Narrative Uterine serous carcinoma is a highly lethal condition, and the harmful effects of fluid-assisted shear stress on its progression remained unexplored. This project will leverage our team's specialized knowledge to unravel the mechanisms by which fluid shear stress promotes the spread of this cancer. By examining and contrasting the characteristics of shear stress in uterine serous carcinoma with those found in the malignant transformation of fallopian tubes into advanced high-grade serous ovarian cancers, and by inhibiting crucial components of the mechanotransduction pathways, we aim to develop innovative treatments for this aggressive disease.

PI_NAMEs: MEHTA, GEETA  (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: 3-Dimensional;Abdomen;Acceleration;Administrative Supplement;Architecture;Area;Ascites;Biological Models;Bioreactors;cancer cell;Cancer Patient;Carcinoma;Carcinoma in Situ;Cell Line;Cell Proliferation;Cell Survival;Cellular Membrane;Cessation of life;Characteristics;chemotherapy;Clinical;combat;Complication;conventional therapy;Development;Diagnosis;Disease;Disease Marker;Disease Progression;Early Diagnosis;Early treatment;Elements;Endometrial Carcinoma;Environment;Epithelial Cells;epithelial to mesenchymal transition;Epithelium;Evolution;Exposure to;Finite Element Analysis;frontier;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Gait;Glycocalyx;Goals;grasp;Immunotherapy;improved;in silico;In Vitro;in vitro Model;inhibitor;innovation;insight;interest;Invaded;Investigation;Ion Channel;kinematics;Knowledge;Lead;Left;Liquid substance;Malignant - descriptor;Malignant Epithelial Cell;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;Maps;mechanical force;mechanical signal;mechanical stimulus;Mechanics;mechanotransduction;Microfluidics;migration;Modeling;Molecular;Movement;Neoplasm Metastasis;neoplastic cell;new therapeutic target;Newly Diagnosed;NF-kappa B;novel;Outcome;Ovarian;Ovary;Papillary;parent grant;Pathology;Pathway interactions;patient derived xenograft model;Patients;Pelvis;pembrolizumab;Peritoneal;Peritoneum;Platinum;Play;Pleural effusion disorder;Positioning Attribute;Primary Neoplasm;promoter;Protein Phosphatase 2A Regulatory Subunit PR53;Publishing;Reactive Oxygen Species;Recurrence;Research;Resistance;response;Role;Serous;shear stress;Signal Pathway;stemness;Surface;targeted treatment;Techniques;Therapeutic;Tissue Microarray;transcriptome sequencing;transcriptomics;treatment strategy;triple-negative invasive breast carcinoma;tumor growth;Uterine Neoplasms;Uterus;Viscosity;Women's Health;Work;Work of Breathing;X-Ray Computed Tomography;Xenograft Model

PROJECT_TITLE: Administrative Supplement for the Study of Shear Stress in Uterine Serous Carcinoma


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Malaysia, a middle-income country that has an expanding HIV epidemic concentrated in people who inject drugs is steeped in high levels of discrimination and intentions to discriminate by HIV treating clinicians. We propose to develop and pilot test a rapid start antiretroviral therapy strategy that we will pilot test as a stigma reduction intervention, which if effective, can be tested in future implementation trials.

PI_NAMEs: ALTICE, FREDERICK LEWIS (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: addiction;Address;Adherence;Administrator;Affect;Africa South of the Sahara;Anti-Retroviral Agents;antiretroviral therapy;anxiety reduction;Architecture;Asia;Behavior;Behavioral;Clinical;clinically relevant;Cohort Studies;Collaborations;comorbidity;Consensus;Country;Data;Decision Making;design;Development;Diagnosis;Discrimination;Drug usage;Education;Elements;Eligibility Determination;Epidemic;evidence base;experience;Face;Future;future implementation;Goals;Guidelines;Health;Health Personnel;Healthcare;Hepatitis C virus;HIV;Hybrids;implementation trial;Imprisonment;improved;improved outcome;Incidence;Income;Individual;Infection;Injecting drug user;Intention;Intervention;intervention refinement;Life;low and middle-income countries;Malaysia;Mediating;Medical Students;medication for opioid use disorder;Methods;mortality;Needle-Exchange Programs;opioid use disorder;Opportunistic Infections;Pathway interactions;Patients;peer;Perception;Persons;Physicians;pilot test;Policies;Population;Prejudice;Prevalence;Process;Productivity;Protocols documentation;Provider;rapid test;Recommendation;Research;Research Methodology;Resources;sex;Sexual Partners;Social Class;social stigma;Social support;Stereotyping;System;systematic review;Techniques;Testing;Therapeutic Intervention;therapy adherence;therapy design;therapy development;Time;tool;transmission process;treatment as prevention;Treatment outcome;Trust;Universities;Viral;Vitamins;Work

PROJECT_TITLE: Reducing Stigma in People Who Inject Drugs with HIV Using a Rapid Start Antiretroviral Therapy Intervention

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome;Organ Transplantation;Transplantation

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Multiple lines of evidence support an important role for local antibody responses in the pathophysiology of cardiac allograft vasculopathy. To date, however, the specificity and function of intragraft plasma cells in human CAV remain unclear. Our studies will use patient specimens to characterize these cells and understand how they contribute to the rejection process.

PI_NAMEs: ZORN, EMMANUEL  (contact)

PROGRAM_OFFICER_NAME: KULKARNI, SHILPA S

PROJECT_TERMS: Affect;Anti-Inflammatory Agents;Antibodies;Antibody Response;Antigen-Antibody Complex;Antigens;Autoantigens;Autoimmune Diseases;B-cell receptor repertoire sequencing;B-Lymphocytes;bile duct;Bilirubin;Binding;Biological Assay;Biological Process;Blood;Blood specimen;Blood Vessels;Cardiac;Catabolism;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;Clone Cells;Complication;conditional knockout;Coronary;Coronary artery;deep sequencing;Deposition;Development;Endothelial Cells;experimental study;expression cloning;Fibroblasts;Fibrosis;Functional disorder;Generations;Heart;heart allograft;Heart Transplantation;Heavy-Chain Immunoglobulins;Heme;Homologous Transplantation;Human;humanized mouse;Immune;immune cell infiltrate;Immune response;Immunity;Immunofluorescence Immunologic;Immunoglobulin Genes;Immunologic Stimulation;immunoregulation;In Situ;In Vitro;in vivo;Individual;Infiltration;Inflammation;Inflammatory;Lesion;Location;Lymphocyte;Maps;Mediating;Molecular;molecular phenotype;Monoclonal Antibodies;Morbidity - disease rate;mortality;MS4A1 gene;neonatal Fc receptor;Pathogenicity;Pathway interactions;Patients;plasma cell differentiation;Plasma Cells;prevent;Process;Property;Reaction;receptor;Recombinants;Research;response;retransplantation;Role;Series;Serology;single-cell RNA sequencing;Site;Somatic Mutation;Specificity;Specimen;Stains;Time;Tissue Grafts;Tissue Sample;Tissues;tool;transcriptome;transplant centers;transplant model;Vascular Diseases;virtual

PROJECT_TITLE: Functional significance of plasma cell infiltrates of human cardiac allograft vasculopathy

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Contraception/Reproduction;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Prevention;Primary Health Care;Screening and Brief Intervention for Substance Misuse;Social Determinants of Health;Substance Misuse;Telehealth;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: PSYCHIATRY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Alcohol and other substance use disorders in reproductive-aged women are of great public health relevance given their association with significant and lifelong adverse physical, mental, and sexual and reproductive health consequences, especially for the most structurally marginalized groups in the U.S. There is an urgent need for new settings and innovative methods to address risky alcohol and substance use in preventive women’s health care contexts in order to improve interrelated health outcomes and equity across the reproductive life course. This implementation trial will evaluate family planning clinics as a novel setting in which to simultaneously test the effectiveness of screening, brief intervention, and referral to treatment (SBIRT) for alcohol and drug use. Coupled with an evidence-based Implementation and Sustainment Facilitation implementation strategy, our findings will ultimately support adoption and scale-up of substance-related care across a premier national sexual and reproductive healthcare organization and its expansive network of FP clinics serving millions of women in the U.S. every year.

PI_NAMEs: GOTHAM, HEATHER J;HALL, KELLI STIDHAM;WELSH, JUSTINE WITTENAUER (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: Academy;Acceleration;Address;Administrator;Adoption;Age;aged;aging population;Alcohol consumption;alcohol measurement;alcohol risk;alcohol screening;alcohol use disorder;Alcohols;Behavioral;behavioral health;Caring;Clinic;Clinical;Community Health;Competence;Computerized Medical Record;condoms;Consolidated Framework for Implementation Research;contextual factors;Contraceptive Agents;Contraceptive methods;Coupled;COVID-19;COVID-19 pandemic;Data;Discipline of obstetrics;Disparity;Disparity population;Drug Screening;Drug usage;effectiveness measure;effectiveness outcome;effectiveness testing;effectiveness/implementation trial;Equity;ethnic minority;Ethnic Minority Women;Ethnic Origin;evidence base;Evidence based intervention;experience;Family Planning;Forcible intercourse;Funding;Gender;Health;health care service organization;health care settings;health equity;health inequalities;health organization;Health Services Accessibility;Healthcare;Heavy Drinking;HIV;hybrid type 1 trial;illicit drug use;implementation facilitation;implementation science;implementation strategy;implementation trial;improved;infant morbidity/mortality;informant;Infrastructure;innovation;Intervention;Interview;Intoxication;Life Cycle Stages;marginalization;marginalized population;maternal morbidity;Maternal Mortality;Medicaid;Medical Electronics;Medicine;Mental Health;Methods;Modeling;multidisciplinary;novel;Outcome;pandemic disease;patient oriented;Patients;Personal Satisfaction;Persons;Pharmaceutical Preparations;physical conditioning;Populations at Risk;Poverty;Pregnancy;Preventive;Preventive healthcare;Primary Care;Process;Process Measure;Provider;Psyche structure;public health relevance;Quality of life;Race;racial minority population;racial minority women;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Records;Reporting;reproductive;Reproductive Health;Resources;response;safety net;scale up;screening, brief intervention, referral, and treatment;Services;sex;sexual and reproductive health;Sexually Transmitted Diseases;Shapes;Site;social disparities;social stress;sociodemographics;Socioeconomic Status;Source;stakeholder perspectives;substance use;Substance Use Disorder;Surveys;System;Technology;Telemedicine;Testing;Training;treatment as usual;Treatment Effectiveness;Trust;underserved community;unintended pregnancy;United States;United States National Institutes of Health;uptake;Urbanicity;Violence;virtual;Visit;Woman;Women's Health

PROJECT_TITLE: Improving alcohol and substance use care access, outcomes, and equity during the reproductive years: A Type 1 Hybrid Trial in Family Planning Clinics

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: NARRATIVE Duplex sequencing offers a way to robustly interrogate the landscape of somatic mutations at single molecule resolution through reducing the error rate of sequencing. A variety of such duplex sequencing approaches are being implemented across the SMaHT Network. We propose to scale up the efforts around duplex sequencing by 1) productionizing CODEC, 2) testing, and implementing HiDEF-seq at the Broad Institute, and 3) exploring the use of targeted duplex sequencing (CODEC, HiDEF-seq, NanoSeq or other) for mutation validation and driver discovery.

PI_NAMEs: ARDLIE, KRISTIN  (contact);LENNON, NIALL JOHN;NATARAJAN, PRADEEP

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: Address;Benchmarking;Biological Assay;Cell Line;Cells;Detection;Experimental Designs;Genes;manufacturing scale-up;Methods;Mutation;Resolution;Sampling;scale up;single molecule;Somatic Mutation;Technology;Testing;Tissues;Validation;Variant

PROJECT_TITLE: Exploration and benchmarking of duplex sequencing


NIH_SPENDING_CATS: Organ Transplantation;Transplantation

ORG_CITY: DURHAM

ORG_DEPT: SURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Vascularized composite allografts (VCAs), which involve the transplantation of a combination of skin, muscle, bone, nerves, offer immediate therapy for individuals who have suffered irreparable tissue damages or deformities (i.e. face, hand etc.). However, VCAs are highly susceptible rejection and also requires life-long immunosuppression which is often toxic to the patients. Therefore, this study aims to utilize a preclinical nonhuman primate model to explore novel therapeutic strategies targeting CD40/CD154 signing pathway with anti-CD154mAb. The ultimate objectives are to minimize VCA rejection, preserve protective immunity, promote tolerance, and optimize patient health.

PI_NAMEs: CENDALES-BEHAINE, LINDA ;KIRK, ALLAN D.;KWUN, JEAN  (contact)

PROGRAM_OFFICER_NAME: KEHN, PATRICIA J

PROJECT_TERMS: Acute;Allografting;allotransplant;anergy;Animals;antibody-mediated rejection;Antigen-Presenting Cells;Antigens;Apoptotic;Autologous;B cell repertoire;B-Lymphocytes;Binding;Blood Transfusion;Blood Vessels;bone;Cells;Clinical;Clinical Management;Clinical Trials;Complement;Data;Deformity;desensitization;Development;efficacy evaluation;efficacy testing;experience;Face;first-in-human;Fostering;Graft Survival;Hand;Health;Immune;Immune response;Immunity;immunogenicity;Immunologic Memory;Immunologic Sensitization;Immunologics;immunoregulation;Immunosuppression;Individual;Infusion procedures;Isoantibodies;ITGAM gene;kidney allograft;Kidney Transplantation;Limb structure;Lymphocyte;Macaca mulatta;Maintenance;Malignant Neoplasms;Modeling;Monoclonal Antibodies;multimodality;Muscle;Nature;nephrotoxicity;Nerve;nonhuman primate;novel;novel therapeutic intervention;Organ Transplantation;Outcome;Pathway interactions;Patients;pharmacologic;Phenotype;Population;post-transplant;pre-clinical;Predisposition;preservation;prevent;Proteasome Inhibitor;Regimen;Research Personnel;response;Signal Pathway;Signal Transduction;Skin;skin allograft;Solid;T-Cell Activation;T-Lymphocyte;Tacrolimus;Testing;Therapeutic;Tissues;TNFRSF5 gene;TNFSF5 gene;Training;Transfusion;transplant model;Transplantation;Transplantation Tolerance;Trauma;trauma care;Uterus;Vascularization;Viral

PROJECT_TITLE: The impact of targeting CD40-CD154 pathway in nonhuman primate vascularized composite allograft model


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Public Health relevant statement This project has the potential to improve T cell therapies. Specifically, the proposal focuses on populations of white blood cells (leukocytes) that are induced upon vaccination of individuals and can protect against microbial infections and tumors. These cells are cytotoxic (CD8+) lymphocytes, and become long-lived upon vaccination, therefore are called 'memory' lymphocytes. They can express multiple functions that are important to protect the host against infectious microbes and to kill tumor cells. We studied and discovered that these cells protect vaccinated host by very precisely orchestrating the effector response of other leukocytes. We propose in this proposal to pursue our dissection of how they achieve such efficient elimination of invading microbial pathogens in vivo with the goal of designing novel immune therapies.

PI_NAMEs: LAUVAU, GREGOIRE STEPHANE (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Abnormal Cell;Amino Acid Motifs;Antigen-Presenting Cells;Antigens;antimicrobial;Autophagocytosis;Bacteria;Binding Proteins;Blood;CASP1 gene;catalyst;CCL3 gene;CCL4 gene;CCR5 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cells;Cellular biology;chemokine;Chemotaxis;Chromatin;Containment;CXCL9 gene;cytokine;Cytoprotection;Dendritic Cells;design;Dissection;Effector Cell;Engineering;Epigenetic Process;Event;experimental study;FBXO32 gene;Funding;gain of function;Genetic;Goals;guanylate;Immune;Immune response;Immunization;Immunize;immunoregulation;Immunotherapy;improved;in vivo;Individual;Infection;Inflammatory;Interferon Type II;Interferons;intravital imaging;Invaded;IRF4 gene;Laboratories;Leukocytes;Ligands;Listeria monocytogenes;loss of function;Lymphocyte;Macrophage;Mediating;Memory;Microbe;microbial;microbicide;Modeling;Molecular;monocyte;mouse model;mucosal site;Mus;Natural Killer Cells;neoplastic cell;NF-kappa B;novel;novel strategies;Outcome;pathogen;pathogenic microbe;Pathway interactions;Phagocytes;Phosphotransferases;Population;prevent;Process;Production;programs;Public Health;Reactive Oxygen Species;recruit;Reporter;response;Role;Signal Transduction;Site;Spleen;Splenic Red Pulp;T cell response;T cell therapy;T-Lymphocyte;Testing;Therapeutic;Tissues;TNF gene;transcription factor;Transcriptional Regulation;transcriptomics;TRIM Motif;tumor;Vaccinated;Vaccination;Vaccines;Vesicular stomatitis Indiana virus;Work;XCL1 gene;XCR1 gene

PROJECT_TITLE: Enhancing Pathogen-Specific Memory CD8+ T cell Responses In Vivo

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;HIV/AIDS;Immunotherapy;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: SAN ANTONIO

ORG_NAME: TEXAS BIOMEDICAL RESEARCH INSTITUTE

PHR: Narrative. Those infected with HIV are at high risk of reactivating latent TB infection. Concurrent antiretroviral therapy and anti-TB therapy does not provide immune reconstitution in TB/HIV co-infection. Our goal is to establish a novel host-directed immunotherapy comprising of IL-21-IgFc fusion protein with cART and 3HP to prevent LTBI reactivation upon HIV co-infection.

PI_NAMEs: SHARAN, RITI  (contact)

PROGRAM_OFFICER_NAME: RADKE, JOSHUA BRYAN

PROJECT_TERMS: 2019-nCoV;Acute;Address;antiretroviral therapy;Antitubercular Agents;Bacteria;Biological;Biological Models;CD4 Lymphocyte Count;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Cessation of life;Chimeric Proteins;Clinical;co-infection;combinatorial;Communicable Diseases;confocal imaging;cytokine;cytotoxic;Data;Development;Disadvantaged;Disease;Dose;Event;experimental study;Failure;Flow Cytometry;Future;Generations;Goals;Gut Mucosa;high risk;HIV;HIV Infections;HIV-1;HIV/TB;HLA-DR Antigens;Human;Immune;immune activation;immune reconstitution;Immune response;Immune System Diseases;Immunity;Immunology;Immunotherapy;improved;Incidence;Individual;Infection;Inflammation;Influenza;interleukin-21;interleukin-21 receptor;Intervention;isoniazid;Knowledge;latent infection;Lung;Macaca;Maintenance;Measures;Mediating;Memory;Modeling;Morbidity - disease rate;mortality;multidisciplinary;Mus;Mycobacterium tuberculosis;Natural Killer Cells;novel;Pathology;Persons;Phase;preservation;prevent;Production;Proliferating;protective efficacy;Proteins;reconstitution;Regimen;Reproducibility;Research;research clinical testing;Resistance;Respiratory Tract Infections;response;Rhesus;rifapentine;Risk;Risk Reduction;Safety;single-cell RNA sequencing;SIV;STAT1 gene;STAT3 gene;Sterilization;Supplementation;syndemic;T cell differentiation;T cell response;T-Lymphocyte;T-Lymphocyte Subsets;Therapeutic;Time;Transcript;Translating;translational approach;treatment response;Tuberculosis;tuberculosis treatment;Vaccines;Viremia;Virus

PROJECT_TITLE: Effect of IL-21 treatment concurrent to ART and 3HP in Mtb/SIV co-infection

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE More than 39 million people are living with HIV-1 infection globally with HIV/AIDS causing >600,000 deaths annually. There is no cure for life-long persistent infection and there are not yet approved therapies to suppress viral gene expression in the context of preventing viral latency reversal. This project studies how HIV-1 hijacks host cellular machineries to regulate viral RNA nuclear export and genome packaging during virion assembly with the goal of informing the development of strategies to inactivate these viral activities in vivo.

PI_NAMEs: SHERER, NATHAN M (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: acute infection;Address;Advanced Development;Anti-viral Therapy;Architecture;Behavior;Binding;Biochemical;Biological Assay;CD4 Positive T Lymphocytes;cell growth regulation;Cell Nucleus;Cells;Cellular biology;Cessation of life;chronic infection;Clinical;Complex;Coupled;Cytoplasm;Data;Detection;Development;Dimerization;experimental study;exportin 1 protein;gag-pol Fusion Proteins;Gene Expression;gene therapy;Genes;Genome;Genome Stability;Goals;HIV;HIV Genome;HIV-1;HIV/AIDS;Human;Image;Imaging technology;in vivo;Infection;innovation;insight;Integration Host Factors;Length;Licensing;light microscopy;Link;live cell imaging;Mediating;Messenger RNA;Methods;Modeling;Mus;mutant;new technology;Nuclear;Nuclear Export;Nuclear Pore;Outcome;Pathway interactions;Persons;prevent;Process;Production;Proteins;Proteomics;receptor;Recording of previous events;recruit;Research;Resistance;rev Protein;rex Gene Products;RNA;RNA Transport;Rodent;Role;single molecule;Site;superresolution imaging;Techniques;Technology;Testing;Time;tool;trafficking;Translating;Translations;ultra high resolution;United States;Viral;Viral Genes;Viral Physiology;viral RNA;Virion;Virus;virus host interaction;Virus Latency

PROJECT_TITLE: The Cell Biology of HIV-1 Genome Trafficking