ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Diabetes;Neurodegenerative;Neurosciences

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: NARRATIVE This research project aims to investigate the complex relationship between recurrent hypoglycemia, vascular responses, and cognitive dysfunction in diabetic rats using a novel head-mounted dual-modality photoacoustic/ultrasound localization imaging technique tailored for freely moving rats. Through a series of experiments involving diabetic rats, we intend to simultaneously observe brain vascular patterns and cognitive behaviors with the influence of hypoglycemia.

PI_NAMEs: CHEN, YUN-SHENG  (contact)

PROGRAM_OFFICER_NAME: LAUGHLIN, MAREN R

PROJECT_TERMS: Acute;Adverse event;Affect;age difference;age group;age related;Alzheimer's Disease;Anesthesia procedures;Anesthetics;Animals;Behavior;Behavior assessment;Behavioral;Blood;Blood flow;Blood Glucose;Blood Vessels;Blood Volume;Body Weight;Brain;brain abnormalities;Brain imaging;brain tissue;Cell Physiology;cerebral blood volume;cerebrovascular;Cerebrovascular Circulation;cerebrovascular imaging;Cerebrovascular system;Cerebrum;Chloralose;Cognitive;cognitive function;cognitive testing;Complex;Data;Dementia;design;Development;Devices;Diabetes Mellitus;diabetic patient;diabetic rat;Diagnosis;Diagnostic;Electroencephalography;Engineering;experimental study;Female;Frequencies;Functional Imaging;Functional Magnetic Resonance Imaging;global health;glucose monitor;glucose sensor;Grant;Head;Hippocampus;Hypoglycemia;hypoglycemia unawareness;Image;imaging modality;Imaging Techniques;Impaired cognition;Impairment;Implant;implanted sensor;Individual;Injections;innovation;insight;Insulin;Intervention;Length;life span;light weight;Link;Location;male;Maps;Mediating;metabolic rate;Methods;middle age;Modality;Monitor;Morphologic artifacts;Motion;Non-Insulin-Dependent Diabetes Mellitus;novel;object recognition;optical fiber;Oxygen;Oxygen Consumption;Patients;Pattern;Pharmaceutical Preparations;Predisposition;Prefrontal Cortex;Prevention;programs;Rattus;Recurrence;Reporting;Research;Research Personnel;Research Project Grants;Resolution;response;Risk;Role;Series;sex;Sex Differences;Streptozocin;Stress;stress reduction;Structure of beta Cell of islet;Telemetry;Testing;Ultrasonic Transducer;ultrasound;Visualization;Weight;wireless

PROJECT_TITLE: Brain Vascular Signatures in Drug-induced Recurrent Hypoglycemia and Associated Cognitive Dysfunction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


ADMINISTERING_IC: DC

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research

ORG_CITY: ROCHESTER

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_FIPS: US

ORG_NAME: ROCHESTER INSTITUTE OF TECHNOLOGY

ORG_STATE: NY

PHR: Project Narrative Measuring the relationship between vocal pitch and the tension and stiffness of vocal tissue in live subjects could lead to a paradigm shift in the diagnosis and monitoring of a range of voice disorders, including atrophy, the scarring or stiffening of the folds, vocal fold nodules, and paralysis. To that end we propose the development of an ultrasound elasticity imaging technique to non-invasively characterize the vocal cord tissue stiffness as a function of voice pitch. The development, validation, and verification of such a technique could lead to more effective treatment and better outcomes for patients with voice disorders.

PI_NAMEs: RICHARDS, MICHAEL SCOTT (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: 3-Dimensional;Acoustics;adduct;age group;Algorithms;Anatomy;Animal Model;Atrophic;Bilateral;Biofeedback;Canis familiaris;Characteristics;Cicatrix;Clinical;Clinical Protocols;computer framework;Computer Models;Data;design;Development;Diagnosis;effective therapy;Elasticity;elastography;Elements;Endoscopy;Etiology;Evaluation;Exhibits;Experimental Models;experimental study;Family suidae;Feedback;Frequencies;Functional disorder;Future;Goals;Human;human subject;Image;Imaging Techniques;improved;in vivo;Laryngeal muscle structure;Larynx;Magnetic Resonance Imaging;Measurable;Measurement;Measures;mechanical properties;Mechanics;men;Methodology;Methods;middle age;Modeling;Modification;Modulus;Monitor;Muscle;Muscle Contraction;Neck;Nodule;novel;older adult;Paralysed;Pathology;Patient Monitoring;patient population;Patient-Focused Outcomes;Patients;Phonation;Play;Population;postoperative recovery;Posture;pressure;Prevalence;Process;Production;Property;Recommendation;respiratory;Risk;Role;Source;Spatial Distribution;Speed;Stress;Techniques;Testing;Tissue Model;Tissues;treatment planning;treatment strategy;Ultrasonic wave;Ultrasonography;ultrasound;Validation;vibration;viscoelasticity;Visualization;vocal control;vocal cord;Voice;Voice Disorders;Woman

PROJECT_TITLE: Ultrasound Elasticity Imaging of the Vibrating Vocal Folds

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-4 (SU)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Heart Disease;Hematology

PHR: Project Narrative Blood pumps and other blood contacting medical devices may cause damage to the cells within the blood itself. Pumps designers design these devices to minimize these negative effects, but no reliable method is currently available to accurately predict these effects during the design process. This project will utilize a novel device developed by our lab to improve our understanding of the effects of shear flow on blood cell viability which will provide critical information to guide the development of next generation blood pumps or other blood contacting medical devices.

PI_NAMEs: DAY, STEVEN  (contact)

PROGRAM_OFFICER_NAME: BECK, LAWRENCE A

PROJECT_TERMS: Adverse effects;Affect;Aliquot;Applied Research;Basic Science;Behavior;Blood;Blood Cells;Blood Coagulation Disorders;blood damage;Blood Platelets;blood pump;Cannulas;Cattle;cell injury;Cell membrane;Cell Survival;Cells;Complex;Computer Models;computer program;Confusion;Consensus;Data;Death Rate;design;Development;Device Designs;Devices;Dialysis procedure;Engineering;Equation;Erythrocytes;experience;experimental study;Exposure to;Family suidae;fluid flow;Funding;Future;Hematology;Hemolysis;Hemolysis Induction;Human;improved;In Vitro;in vitro testing;Injury to Kidney;Laws;Lead;Liquid substance;Magnetism;Mathematics;Measurement;Mechanics;Mediating;Medical Device;Membrane Oxygenators;Methods;Modeling;Modernization;next generation;nonlinear regression;novel;Outcome;Oxygenators;Patients;Pharmacologic Substance;Physiological;Plasma;Platelet Activation;pre-clinical;predictive modeling;Process;Property;Prosthesis;Publications;Pump;quantum;Reporting;Research;Research Personnel;Rotation;shear stress;Sheep;Statistical Data Interpretation;Stress;Technology;Thrombosis;Time;tool;Variant;ventricular assist device;Whole Blood

PROJECT_TITLE: Quantifying the Effects of Shear Flow on Blood using a Magnetically Levitated Device


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Mental Health

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Narrative This project investigates sexual well-being, a crucial yet often overlooked element of overall health and well- being. By developing a comprehensive model and self-report scale of sexual well-being, we aim to substantially improve our understanding and measurement of this important life domain, thereby paving the way for more effective research, interventions, policies, and education. This could have implications for reducing sexual violence and risk-taking while fostering healthy relationships and improving mental health.

PI_NAMEs: LUDWIG, VERA URSULA (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Address;Adopted;Adult;Age;Benchmarking;candidate identification;Caring;Clinical;clinical application;clinical practice;Coercion;Cognitive;cognitive interview;Data Analyses;design;Development;Dimensions;Disease;Education;Elements;Emotional;Ensure;Evaluation;experience;Factor Analysis;Feedback;Feeling;Focus Groups;Fostering;Foundations;Functional disorder;Future;Gender;Goals;Growth;handicapping condition;Health;health equity;improved;Individual;Individual Differences;insight;International;Interpersonal Relations;Intervention;Interview;intimate behavior;Investigation;Leadership;Life;life span;loved ones;Maps;Measurement;Measures;Mental disorders;Mental Health;Methodology;Modeling;multidisciplinary;Outcome;Participant;Patient Self-Report;Pennsylvania;Personal Satisfaction;Phase;physical state;Physiological;Pilot Projects;Policies;Population;Predictive Value;Probability Samples;Process;Psyche structure;psychologic;psychological distress;Psychologist;Psychology;Public Health;Public Health Administration;Qualifying;Quality of life;Questionnaires;Research;Research Personnel;Review Literature;Risk Behaviors;Risk Taking;Sampling;screening;Sex Functioning;Sexology;Sexual Development;Sexual Health;sexual violence;Sexuality;Sexually Transmitted Diseases;Shapes;skills;Social Well-Being;Solid;Source;Subgroup;Surveys;Testing;timeline;Universities;Validation;Violence;Weight;Work

PROJECT_TITLE: Developing and Validating a Multi-Dimensional Scale of Sexual Health

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Nutrition;Prevention;Rare Diseases

ORG_CITY: Los Angeles

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE Head neck squamous cell carcinoma (HNSCC) is common and aggressive cancer without effective therapy. In this proposal, we will: i) focus on the crosstalk between cancer metabolism and epigenetic regulation to study the primary forces transforming normal oral cells into HNSCC using advanced organoid technology and mouse models; ii) investigate the pharmacological and dietary inhibition of the link between methionine metabolism and epigenetic network. Our work holds the promise to fundamentally transform the understanding of cancer initiation of HNSCC, while simultaneously discovering novel intervention strategies and treatment targets for this cancer.

PI_NAMEs: LIN, DE-CHEN  (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: addiction;Address;Animal Model;Antibodies;Benign;Bioinformatics;Biological;Biological Assay;Biological Markers;Biological Models;Cancer Biology;cancer cell;cancer initiation;cancer prevention;cancer therapy;Carcinoma in Situ;Cell Line;Cell Survival;Cells;Cleavage Under Targets and Release Using Nuclease;Coupled;CRISPR/Cas technology;Deglutition Disorders;Dependence;Development;Diet;dietary;Dietary Intervention;Dysplasia;Early identification;Early Intervention;Early treatment;effective therapy;Epigenetic Process;epigenetic regulation;epigenome;epigenomics;Epithelial Cells;Evolution;Exhibits;experimental study;EZH2 gene;FDA approved;fitness;gain of function;genome editing;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Healthcare;histone methylation;Homocysteine;HPV-negative head and neck cancer;Human;human model;improved;inhibitor;Inter-tumoral heterogeneity;Intervention;Investigation;Lesion;Leukoplakia;Link;loss of function;Luciferases;malignant mouth neoplasm;Malignant Neoplasms;Maps;Mediating;Metabolic;Metabolism;metabolomics;Methionine;Methionine Metabolism Pathway;Methylation;Modeling;Molecular;mouse model;Mouth Neoplasms;Mucositis;Mus;Neoplasms;neoplastic;Neoplastic Cell Transformation;novel;Oral;Oral cavity;oral cavity epithelium;Organoids;painful swallowing;Pathologic;Pathway interactions;Patients;pharmacologic;Phase I Clinical Trials;Physiologic pulse;Precancerous Conditions;preclinical evaluation;premalignant;Prevention;preventive intervention;Proliferating;Quality of life;Reaction;Regulation;Reporter;Reporting;S-Adenosylhomocysteine;S-Adenosylmethionine;Sampling;side effect;Squamous Epithelium;Stratified Squamous Epithelium;System;Technology;Testing;Therapeutic;therapeutically effective;Tissue Sample;Toxic effect;transcriptome sequencing;tumor;tumor metabolism;Work;Xerostomia

PROJECT_TITLE: Pharmacological and dietary inhibition of a novel metabolic-epigenetic crosstalk in head and neck cancer

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Genetics

ORG_CITY: SAN JOSE

ORG_DEPT: BIOLOGY

ORG_NAME: SAN JOSE STATE UNIVERSITY

PHR: Project Narrative Increased intracellular pH, or a reduction of acid levels inside cells, is an under-recognized hallmark of cancers regardless of the tissue of origin or underlying genetic mutations. The altered chemical environment can cause aberrant activities of select proteins to promotes tumorigenesis. This project will help us understand how proteins are regulated by acid levels, and how this contributes to tumor growth.

PI_NAMEs: GRILLO-HILL, BREE K. (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Acids;Affect;Amino Acids;Apoptosis;Area;Autophagocytosis;Binding;Biology;cancer cell;Cancer Model;candidate identification;carcinogenesis;Carrier Proteins;cell behavior;Cell Count;Cell Death;Cell membrane;Cell model;cell motility;Cell Physiology;Cell Survival;Cells;Chemicals;Complex;Data;Disinhibition;DNA Sequence Alteration;driver mutation;Drosophila eye;Drosophila genus;Dysplasia;Environment;experience;extracellular;Eye;fly;functional group;Genes;Genetic;Genetic Models;genetic regulatory protein;Genetic Transcription;Growth;Histidine;Individual;insight;Ion Transport;Ions;Link;Malignant Neoplasms;Mammalian Cell;Mammals;Maps;MDCK cell;Measures;Mediating;Methods;model organism;Modeling;Molecular;molecular marker;mutant;Mutation;MYC Family Protein;MYC gene;Necrosis;Neoplasm Metastasis;NHE1;Oncogenes;Oncogenic;Orthologous Gene;Outcome;Ovary;overexpression;Pathway interactions;Pattern;Phenotype;Physiological;predictive modeling;Proliferating;Protein Conformation;protein function;Proteins;Proto-Oncogenes;protonation;Protons;Publishing;Reagent;Recycling;Regulation;Regulatory Pathway;Repression;Retina;sensor;Sodium;Specificity;System;Tertiary Protein Structure;Testing;Therapeutic;Tissues;Titrations;tool;Transcript;transcription factor;transcriptome sequencing;Transgenic Organisms;tumor;tumor growth;Tumor Promotion;tumorigenesis;Wing

PROJECT_TITLE: Increased Intracellular pH Promotes Cancer Cell Behaviors

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-A (SU)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Neurofibromatosis;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: EDINBURG

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF TEXAS RIO GRANDE VALLEY

ORG_STATE: TX

PHR: PROJECT NARRATIVE The brain white matter and its characteristic component myelin have emerged as key regulators of brain function, and their disruption potentially contributes to neurological conditions observed in children with Neurofibromatosis type 1 (NF1). Here, myelin-focused mouse genetic models of NF1 will be used to unveil developmental and functional abnormalities of myelinating cells, abnormalities which potentially impact activity and learning in a voluntary learning test. By discovering mechanisms and their precise windows of time, these studies will facilitate the establishment of early preventive or remedial treatments for neurological issues in NF1, based on maintain- ing, restoring, or improving the function of myelin.

PI_NAMEs: LOPEZ JUAREZ, ALEJANDRO  (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: 1 year old;Address;Adolescent;Adult;Affect;Attention deficit hyperactivity disorder;Authorship;Behavior;Biology;Brain;brain dysfunction;Cell Death;Cells;Characteristics;Child;Communication;Complex;Data;Dedications;Development;Disease;Event;experience;First Generation College Students;functional improvement;Genetic Diseases;Genetic Models;Genetic Recombination;Goals;Hispanic;Hyperactivity;Impairment;improved;Incidence;Individual;Infant;Intervention;Knowledge;Learning;Learning Disabilities;Link;MAP Kinase Gene;Medial;Mediator;meetings;Mendelian disorder;Minority;minority undergraduate;Mission;Modeling;molecular dynamics;Moods;motor learning;Motor Skills;mouse genetics;mouse model;Mus;mutant;Mutate;Mutation;Myelin;Natural History;Nervous System Disorder;Neurofibromatosis 1;Neurologic;neuropathology;Neurosciences;NF1 gene;NF1 mutation;oligodendrocyte lineage;oligodendrocyte progenitor;Oligodendroglia;Paper;Pathway interactions;Patients;pediatric patients;Phenotype;Population;postnatal;postnatal development;Preventive;Production;Proliferating;Publications;Recombinants;recruit;Research;restoration;Role;Running;Schedule;Schools;Science;Shapes;skills;Specificity;Students;Symptoms;System;Tamoxifen;Testing;Therapeutic;therapeutic target;Time;tool;Training;undergraduate student;United States National Institutes of Health;white matter

PROJECT_TITLE: The Impact of Nf1 Mutation on Oligodendrocyte Development and Fine Motor Learning

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-W (SU)]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: ANN ARBOR

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The so-far-unavailable, combined optical tweezers/single molecule super-resolution fluorescence microscope proposed here will be housed in the well-established, open-access, shared-use Single Molecule Analysis in Real-Time (SMART) Center at the University of Michigan to serve a broad biomedical user base in the state of Michigan. The PI Walter (University of Michigan) and key collaborator Comstock (Michigan State University) are experts in single molecule fluorescence microscopy and optical tweezers combined with single molecule fluorescence observation, respectively. In addition to best-in-class force sensitivity and integrated imaging capabilities, the proposed C-Trap instrument offers user-friendly software with a streamlined experimental workflow that will advance the goals of 7 Major and 10 Minor, overwhelmingly NIH-funded User groups working on a broad range of biomedical research problems.

PI_NAMEs: WALTER, NILS G (contact)

PROGRAM_OFFICER_NAME: AGGARWAL, MONIKA

PROJECT_TERMS: Advisory Committees;base;Biomedical Research;Biophysics;Cellular biology;Charge;Communities;Complement;Core Facility;Data Analyses;Disease;Doctor of Philosophy;Ensure;experience;experimental study;Extramural Activities;Fluorescence;fluorescence microscope;Fluorescence Microscopy;Funding;Future;Goals;imaging capabilities;Institution;instrumentation;Intake;Journals;laser tweezer;Lasers;Michigan;Minor;nanoscope;next generation;optic trap;optic tweezer;optical traps;Phase;Photons;Productivity;programs;protein folding;Publications;Research;Research Personnel;Resources;RNA;RNA Folding;Role;Scanning;Schools;single molecule;System;Time;Training;ultra high resolution;United States National Institutes of Health;Universities;user friendly software

PROJECT_TITLE: Combined Optical Tweezers-Single Molecule Super-Resolution Fluorescence Microscope in the Open-Access SMART Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-D (30)]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: KEY BISCAYNE

ORG_NAME: UNIVERSITY OF MIAMI ROSENTEIL SCHOOL

ORG_STATE: FL

PHR: The California sea hare, Aplysia californica, is a large marine snail that has proven to be an outstanding model for studies of how the nervous system functions, particularly in memory and learning, as well as in understanding human diseases that affect these functions. The National Resource for Aplysia raises and ships 8,000-10,000 animals per year to research laboratories. This proposal would continue the production of these animals and expand their usefulness for studies of the mechanisms of resistance to the type of injuries encountered in stroke and cardiovascular disease.

PI_NAMEs: SCHMALE, MICHAEL C (contact)

PROGRAM_OFFICER_NAME: ZOU, SIGE

PROJECT_TERMS: Abdomen;Adult;Affect;Age;age effect;aged;Animals;antioxidant enzyme;Aplysia;Aplysia species;Applied Research;Behavior;Biological Models;Biomedical Research;California;Cardiac;Cardiovascular Diseases;Cerebral Ischemia;Characteristics;Child;cohort;Communities;cost;Data;Data Reporting;Development;Diet;Disease;DNA;Education;Educational process of instructing;egg;Environment;experience;Exposure to;Ganglia;Goals;graduate student;Harvest;Health;Heart;heart function;Human;human disease;Hypoxia;improved;Informatics;Injury;innovation;Ischemia;Laboratory Research;Larva;Learning;Life;life span;marine;mature animal;Memory;Mission;Mitochondria;model organism;Modeling;Molecular;Monitor;Myocardial Reperfusion Injury;Nervous System;Nervous System Physiology;neural;novel;Oceans;Organism;outreach;Pathology;Photoperiod;Planet Earth;Play;Population;Predisposition;Prevalence;Preventive treatment;Production;programs;Reperfusion Injury;Reperfusion Therapy;Research;Research Personnel;Research Project Grants;resilience;Resistance;resistance mechanism;Resources;RNA;Role;Sales;Schools;science teacher;screening;senescence;Services;Shipping;Ships;Siblings;slug;Snails;Stroke;Study models;System;Temperature;Testing;Time;Tissues;Training and Education;training opportunity;transmission process;undergraduate student;Universities;Variant;Virus;water quality;web interface;web site

PROJECT_TITLE: The National Resource for Aplysia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-J (55)]


NIH_SPENDING_CATS: Aging;Neurosciences

PROJECT_TERMS: Abdomen;Adult;Affect;Age;age effect;aged;animal old age;Animals;Aplysia;Aplysia species;Applied Research;Behavior;Biological Assay;Biological Models;Biomedical Research;California;Caloric Restriction;Cardiac;Cardiovascular Diseases;Cerebral Ischemia;Characteristics;cohort;Communities;cost;Development;Diet;Disease;DNA;Education;Educational process of instructing;egg;Embryo;Environment;Exposure to;Ganglia;Goals;graduate student;Harvest;Health;Heart;heart function;Human;human disease;Hypoxia;improved;Individual;Informatics;Injury;innovation;Ischemia;juvenile animal;Laboratory Research;Larva;Learning;Life;life span;marine;mature animal;Measures;Memory;Methods;Mission;Mitochondria;model organism;Modeling;Molecular;Monitor;Myocardial Reperfusion Injury;Nervous System;Nervous System Physiology;neural;novel;Organism;outreach;Photoperiod;Play;Population;Predisposition;Production;programs;Reperfusion Injury;Reperfusion Therapy;Research;Research Personnel;Research Project Grants;Resistance;resistance mechanism;Resources;RNA;Role;Sales;Sampling;screening;senescence;Services;Ships;Siblings;Snails;Stroke;Study models;System;Temperature;Testing;Time;Tissues;training opportunity;transmission process;undergraduate student;Universities;Variant;viral RNA;Virus;water quality;web interface;web site

PROJECT_TITLE: National Resource for Aplysia - Resources


NIH_SPENDING_CATS: Aging;Cardiovascular;Neurosciences

PROJECT_TERMS: Abdomen;Adult;Affect;Age;age effect;aged;animal resource;Animals;Aplysia;Aplysia species;Applied Research;Area;Awareness;Bar Codes;Behavior;Biological Models;Biomedical Research;California;Cardiac;Cardiovascular Diseases;Cerebral Ischemia;Characteristics;Child;cohort;Communities;Computer software;cost;Data;Databases;design;Development;Diet;DNA;Education;Education and Outreach;Educational process of instructing;egg;Equipment and supply inventories;Exposure to;Ganglia;General Population;graduate student;Grant;Harvest;Health;Heart;heart function;Human;human disease;Hypoxia;improved;Informatics;Injury;innovation;Internet;Ischemia;Laboratory Research;Learning;Life;life span;marine;Memory;Mission;Mitochondria;model organism;Modeling;Molecular;Monitor;Myocardial Reperfusion Injury;Nervous System;Nervous System Physiology;neural;Neurosciences Research;novel;Oceans;Organism;outreach;payment;Planet Earth;Play;Predisposition;Production;programs;Publications;Reperfusion Injury;Reperfusion Therapy;Reporting;Research;Research Personnel;Research Project Grants;Resistance;resistance mechanism;Resources;RNA;Role;Sales;Schools;science teacher;searchable database;Shipping;Ships;slug;Snails;Stroke;Study models;System;Time;Tissues;Training;Training and Education;training opportunity;undergraduate student;Universities;Variant;Virus;web interface;web site

PROJECT_TITLE: The National Resource for Aplysia-Curation & Informatics.


PI_NAMEs: MCDONALD, M DANIELLE (contact)

PROJECT_TERMS: Abdomen;Adult;Affect;Age;age effect;aged;Aging;Animals;Aplysia;Aplysia species;Applied Research;Behavior;Biological Models;Biomedical Research;California;Cardiac;cardiac aging;Cardiovascular Diseases;Cardiovascular system;Cerebral Ischemia;Characteristics;cohort;Complex;cost;Diet;DNA;Education;Educational process of instructing;egg;Elderly;Exposure to;Ganglia;Glutamates;graduate student;Harvest;Health;Heart;heart function;Human;human disease;Hypoxia;improved;Individual;Informatics;Injury;innovation;Investigation;Ischemia;Ischemic Stroke;Laboratory Research;Learning;Life;life span;marine;Memory;Mission;Mitochondria;model organism;Modeling;Molecular;Monitor;Mus;Myocardial Reperfusion Injury;Nervous System;Nervous System Physiology;neural;Neurons;Norepinephrine;novel;Organism;outreach;Play;Predisposition;Preventive therapy;Preventive treatment;Process;Production;programs;Rattus;Reperfusion Injury;Reperfusion Therapy;Research;Research Personnel;Research Project Grants;Resistance;resistance mechanism;Resources;response;Risk Factors;RNA;Rodent Model;Role;Sales;senescence;Ships;Snails;Stroke;Study models;System;targeted treatment;Tissues;training opportunity;transcriptomics;undergraduate student;Universities;Variant;Vertebrates;Virus;web interface;web site

PROJECT_TITLE: The National Resource for Aplysia - Applied Research


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biomedical Imaging;Brain Disorders;Complementary and Integrative Health;Dietary Supplements;Epilepsy;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_CITY: BETHESDA

ORG_NAME: HENRY M. JACKSON FDN FOR THE ADV MIL/MED

ORG_STATE: MD

PHR: Project Narrative The neuroprotective and anti-inflammatory efficacy of the omega-3 nutraceutical alpha-linolenic acid and its endogenously derived oxylipins will be tested to prevent the expected pathologic white matter microstructural, alterations and the inflammatory response and a reduction in the default mode network after OP exposure.

PI_NAMEs: MARINI, ANN M (contact)

PROGRAM_OFFICER_NAME: SPRIGGS, SHARDELL M

PROJECT_TERMS: Acetylcholine;Acetylcholinesterase;Acids;Acute;alpha-Linolenic Acid;Anatomy;Animal Model;Animals;Anti-Inflammatory Agents;Antiinflammatory Effect;Arachidonic Acids;Attenuated;Behavioral;biomarker discovery;Brain;Brain Injuries;Brain region;Central Nervous System;Cerebellum;cerebrovascular;Cessation of life;cingulate cortex;Clinical;Coupled;Data;Diarrhea;Diffusion Magnetic Resonance Imaging;Discriminant Analysis;Enzymes;Epileptogenesis;Equilibrium;Excitatory Amino Acids;excitotoxicity;experimental arm;Exposure to;Female;Functional Imaging;Functional Magnetic Resonance Imaging;Future;gray matter;Hippocampus;Human;Image;Impairment;improved;in vivo;Induced Neurons;Inflammation;Inflammation Mediators;Inflammatory Response;insight;Intervention;Isoflurophate;Least-Squares Analysis;Limbic System;Linoleic Acids;Linolenic Acids;lipidomics;Liquid Chromatography;Magnetic Resonance Imaging;male;Mass Spectrum Analysis;Mediating;Mediator;medical countermeasure;Military Personnel;Modeling;Monkeys;MRI Scans;Muscarinic Acetylcholine Receptor;Nerve Degeneration;Neuronal Plasticity;Neurons;neuroprotection;Nicotinic Receptors;Nutraceutical;Omega-3 Fatty Acids;Omega-6 Fatty Acids;Organophosphates;Outcome;Pathologic;Peripheral Nervous System;Pharmaceutical Preparations;Polyunsaturated Fatty Acids;Population;Populations at Risk;prevent;Prevention;Process;Production;quantitative imaging;Reporting;Resolution;Respiratory distress;Rest;Safety;Sarin;Seizures;Severities;Soman;Sprague-Dawley Rats;standard of care;Status Epilepticus;Structure;Study models;Subway;Survivors;Synapses;Testing;Time;Tokyo;toxic organophosphate insecticide exposure;tractography;Tremor;Vomiting;white matter;white matter change;white matter damage;white matter injury

PROJECT_TITLE: Inflammation and white matter microstructural alterations after OP exposure

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-F (54)]


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Dissemination and Implementation Research;Health Services;Hearing Loss;Neurosciences;Prevention;Rehabilitation

ORG_CITY: Aurora

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The proposed research will examine the self-reported, behavioral, cognitive and neurophysiologic outcomes of emerging over-the-counter (OTC) hearing aid service delivery models by comparing them to gold standard prescription hearing aids fitted by hearing care professionals. Moreover, implementation science elements such as examining the profiles of people who will choose different elements of hearing aid service delivery models, stakeholders' perspectives on barriers and facilitators to implementation as well as cost analysis of the four service delivery models will allow us to fast track the results to practice. Results of this project will provide timely information on emerging OTC hearing aid service delivery models to inform clinical practice and the policy decisions.

PI_NAMEs: MANCHAIAH, VINAYA  (contact);SHARMA, ANU

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Address;Adult;Affect;arm;Audiology;Awareness;Behavioral;Brain;Caring;Categories;Chronic;Clinical;clinical implementation;clinical practice;Cognition;Cognitive;comparative effectiveness;compare effectiveness;Congresses;Consultations;contextual factors;cost;Cost Analysis;Country;Data;density;Devices;digital;Economics;effective therapy;effectiveness evaluation;effectiveness outcome;effectiveness/implementation study;effectiveness/implementation trial;efficacy outcomes;Elements;Emotional;EP300 gene;health care economics;health care service;health information technology;Health Professional;health related quality of life;Health Services Research;Hearing;Hearing Aids;hearing disability;hearing impairment;implementation facilitators;implementation science;Improve Access;improved;Income;indexing;Individual;informant;Insurance;Intervention;Interview;Maps;Measures;mental state;Methods;microphone;Mission;Modality;Modeling;multidisciplinary;National Institute on Deafness and Other Communication Disorders;Neurocognitive;Neuronal Plasticity;neurophysiology;Noise;Outcome;Patient Self-Report;Patient-Focused Outcomes;Patients;Persons;Policies;policy recommendation;Population;population health;Presbycusis;primary endpoint;processing speed;Professional Organizations;prospective;Provider;randomized, clinical trials;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;reconstruction;Remote Consultation;Research;Safety;satisfaction;Scalp structure;Self Management;service delivery;Service delivery model;Short-Term Memory;social stigma;Speech Perception;stakeholder perspectives;Statutes and Laws;Structure;trial design;uptake;verbal;Vision;Visual evoked cortical potential

PROJECT_TITLE: Emerging Service Delivery Models for Over-the-Counter Hearing Aids: A Hybrid Effectiveness-Implementation Trial

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Liver Disease;Nutrition;Obesity;Prevention

ORG_CITY: LOS ANGELES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: CHARLES R. DREW UNIVERSITY OF MED & SCI

PHR: Project Narrative: The increasing prevalence of insulin resistance (IR) and non-alcoholic fatty liver diseases (NAFLD) in the USA requires continued effort to define underlying mechanisms and identify new drug targets. This project will investigate the causative role of P53-CARF interplay in IR and NAFLD and establish that understanding its function will help manage IR and NAFLD.

PI_NAMEs: HASAN, KAMRUL M (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Adipose tissue;Applications Grants;Automobile Driving;Award;Binding;Biological Assay;Biomedical Research;Black race;cancer cell;cancer prevention;Cardiometabolic Disease;Cardiovascular Diseases;Caring;cell growth;Cell model;Cell Proliferation;Cell Survival;Cells;ChIP-seq;chromatin immunoprecipitation;Cleavage Under Targets and Release Using Nuclease;Clinical;Co-Immunoprecipitations;cofactor;combat;Coupled;Data;db/db mouse;Deposition;design;Development;Diabetes Mellitus;diet-induced obesity;Dietary Fats;Disease;Disease Resistance;Education;Enrollment;Epidemic;Fatty acid glycerol esters;Fatty Liver;Foundations;Functional disorder;Gene Expression;Genes;Genetic Transcription;Genotoxic Stress;Gluconeogenesis;glucose disposal;glucose metabolism;glucose output;glucose production;Glycogen;graduate student;Grant;Health;Health Disparities Research;Hepatic;hepatic gluconeogenesis;Hepatocyte;Hispanic;HIV/AIDS;Homeostasis;Human;human model;Hyperglycemia;Impairment;In Vitro;in vivo;Insulin;Insulin Resistance;insulin sensitivity;insulin signaling;Insulin Signaling Pathway;knock-down;lipid metabolism;Liver;Liver diseases;Los Angeles;Malignant Neoplasms;MDM2 gene;Mediating;Medicine;member;Mentors;Metabolic;Metabolic Diseases;Metabolic stress;Minority-Serving Institution;Modeling;Molecular;mouse model;Mus;new therapeutic target;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;Normal Cell;novel;Nutrient;Obese Mice;Obesity;Outcome;overexpression;Pancreas;Pathway interactions;Play;Population;Postbaccalaureate;Prevalence;prevent;programs;protein expression;protein function;Proteins;Publications;Reading Frames;recruit;Reporting;Research;Research Personnel;Research Support;response;restoration;Risk Factors;Rodent;Role;Science;Solid;Stress;stressor;student training;Students;summer research;Technical Expertise;Tissues;TP53 gene;Training;transcriptome sequencing;Tumor Suppressor Proteins;undergraduate student;Underrepresented Minority;Universities;Up-Regulation

PROJECT_TITLE: Impact of inverse relationship between TP53 and CARF on the development of hepatic steatosis and insulin resistance


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Dental, Oral, and Craniofacial Disease

ORG_CITY: BALTIMORE

ORG_NAME: MORGAN STATE UNIVERSITY

PHR: PROJECT NARRATIVE This proposal will characterize the drug spray to nasal cavity with both particle deposition and mucociliary clearance in consideration. We will develop a novel computational fluid dynamics model for this process validated by in-vivo data for the first time. This project will provide a robust predictive tool to investigate the drug spray to nasal cavity, improve the research capabilities in biomedical at Morgan State University as HBCU, provide high-quality research opportunities to students at HBCU, and contribute significant to PI’s research development.

PI_NAMEs: LI, ZHENG  (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: absorption;adaptive immune response;Address;Adrenal Cortex Hormones;Adverse effects;Affect;age group;Air Movements;airway epithelium;Anatomy;Area;Back;Biomedical Research;career development;Chronic;chronic rhinosinusitis;Cilia;Clinical;Collaborations;Computer Models;Coupling;Data;Deglutition;Deposition;Diffusion;Drug Delivery Systems;Drug Modelings;Drug Transport;Economic Burden;Epithelial Cells;Equation;Fatigue;fluid flow;fluticasone;Goals;graduate student;Hyperglycemia;improved;in silico;In Vitro;in vivo;in vivo Model;Incidence;Inflammation;Inhalation;insight;Institution;interdisciplinary approach;Investigation;Irrigation;Knowledge;Liquid substance;Manic;mathematical model;Measurement;Mediating;Medical;meetings;Mental Depression;Mentorship;Methodology;Methods;Modeling;Morbidity - disease rate;Movement;Mucociliary Clearance;Mucous body substance;Mucous Membrane;Nasal cavity;Nasal Epithelium;North Carolina;Nose;novel;Operative Surgical Procedures;Osteoporosis;Outcome;particle;pathogen;Patients;Pharmaceutical Preparations;Physiological Processes;Physiology;poor sleep;predictive tools;Process;Production;programs;Quality of life;Regional Anatomy;Research;research and development;Research Infrastructure;Respiratory System;Scanning;side effect;Sinus;sleep regulation;Spectrophotometry;Students;Surface;Time;Tissues;tool;Translations;undergraduate student;Universities;Weight Gain;Work;X-Ray Computed Tomography

PROJECT_TITLE: Subject specific modeling of drug absorption in nasal cavity


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

PHR: Project Narrative Streptococcus pneumoniae causes over 150,000 hospitalizations annually in the U.S., with a mortality rate of 5-7%, making the disease both a significant health and financial burden. The goal of the proposed research is to elucidate the role of a S. pneumoniae toxin in damaging the lung epithelium, a crucial event that promotes bacterial dissemination from the lungs to the blood and causes more severe disease. Understanding how this toxin contributes to more severe outcomes in patients will help us design novel therapies to combat pneumoniae and other lung infections.

PI_NAMEs: ADAMS, WALTER ISAIAH (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Adherens Junction;afadin;Air;Antibodies;Aspartic Endopeptidases;Blood;Caspase;Cell Death;Cell Line;Cell membrane;Cells;Chelating Agents;Chemicals;Cholesterol;combat;Computer software;Confocal Microscopy;CRISPR/Cas technology;Cytolysins;Death Rate;design;Disease;E-Cadherin;Epithelial Cells;Epithelium;Event;Excision;experimental study;Financial Hardship;Fluorescence;Fluorescent Antibody Technique;Genes;genetic approach;Goals;Health;Hospitalization;Image;Image Analysis;Individual;Infection;inhibitor;Intercellular Junctions;Ions;junctional adhesion molecule;Knock-out;Liquid substance;Lung;Lung infections;lung injury;Measures;Mediating;Metalloproteases;Modeling;monolayer;mutant;nectin;novel therapeutics;occludin;Outcome;Pathway interactions;Patients;Peptide Hydrolases;Pneumonia;Propidium Diiodide;protein E;Proteins;quantitative imaging;Reader;Research;respiratory pathogen;Role;Serine Protease;Stains;Statistical Data Interpretation;Streptococcus pneumoniae;Streptococcus pneumoniae plY protein;System;Tight Junctions;Toxin;Virulence Factors;Western Blotting

PROJECT_TITLE: Mechanism of Toxin Mediated Damage to the Lung Epithelium during S. pneumoniae Infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 MMO-D (J1)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: SAN FRANCISCO STATE UNIVERSITY

PHR: Reducing adolescent substance use remains a critical public health goal because the majority of adult substance users begin using as adolescents. Substance use is negatively associated with socioeconomic status (SES), but we do not yet know about the associations between SES discrimination and substance use. The proposed research provides new information about the association between SES discrimination and substance use among adolescents.

PI_NAMEs: MELLO, ZENA R. (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: Adolescence;Adolescent;adolescent substance use;Adult;Age;Alcohol consumption;Alcohols;Cannabis;cigarette smoke;Collaborations;Consent;Data;Data Collection;Development;Discrimination;Doctor of Philosophy;Education;ethnic discrimination;Ethnic Origin;experience;Funding;Gender;graduate student;Grant;harassment;health disparity;health goals;high school;Hispanic-serving Institution;Illicit Drugs;Income;Individual;intervention program;Interview;Knowledge;Letters;Logistic Regressions;Longitudinal Studies;Low income;Mentors;Methods;microaggression;minority stress;Modeling;National Institute of Drug Abuse;Occupations;Paper;perceived discrimination;prevent;Prevention program;Procedures;programs;Public Health;Publications;Race;racial discrimination;recruit;reduced substance use;Research;San Francisco;Schools;Sex Discrimination;Sex Orientation;Socioeconomic Status;Strategic Planning;Stress;student mentoring;student training;Students;Subgroup;substance use;substance use prevention;substance user;Surgeon;Surveys;theories;Tobacco;Tobacco use;undergraduate student;Underrepresented Students;United States National Institutes of Health;Universities;vaping;Work

PROJECT_TITLE: Substance Use and Perceived Discrimination Based on Socioeconomic Status Among Adolescents

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-8 (SU)]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative Genes on chromosome 1p36, including RERE and SPEN, are deleted or altered in some people who are born with heart defects. In these studies, we will use mouse models to learn how altering RERE and SPEN leads to abnormal heart development. These studies will help us provide better medical care to individuals with heart defects and may ultimately lead to the development of new ways of preventing or treating these defects.

PI_NAMEs: SCOTT, DARYL ARMSTRONG (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: 1p36;1p36 deletion syndrome;Ablation;Affect;Brain;cardiogenesis;Caring;Cell Death;Cell Proliferation;Cells;Chromosome Deletion;Chromosomes;cohort;Complex;congenital heart abnormality;Congenital Heart Defects;Critical Congenital Heart Defects;Data;Defect;Development;Disease;Embryo;Endocardium;Endothelium;experimental study;Eye;Foundations;GATA4 gene;Genes;Genetic Transcription;Goals;HDAC1 gene;Heart;heart defect;House mice;Human;human disease;Incidence;Individual;innovation;Intervention;Knockout Mice;Knowledge;Laboratories;Lead;Learning;Medical;Mesenchymal;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Neurodevelopmental Disorder;Newborn Infant;Nuclear Receptors;Pathogenicity;Pathway interactions;Pattern;Persons;Play;Population;prevent;preventive intervention;Proliferating;promoter;Proteins;Publishing;Radio;Resources;retinoic acid receptor alpha;Risk;Role;Structural Congenital Anomalies;Syndrome;Techniques;Testing;Therapeutic Intervention;Time;Tissues;United States;Variant;Ventricular Septal Defects;Ventricular septum;Work

PROJECT_TITLE: The Role of RERE and SPEN in the development of 1p36 Deletion-Related Congenital Heart Defects

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: HUNTSVILLE

ORG_NAME: SAM HOUSTON STATE UNIVERSITY

PHR: PROJECT NARRATIVE Most biomedical disciplines face a chronic shortage of skilled researchers from diverse backgrounds who are adequately prepared and motivated to pursue doctoral studies. As a minority-serving and a top ranked institution for social mobility with a recently established medical school, Sam Houston State University (SHSU) is ideally suited to address this disparity in biomedical workforce by implementing the proposed Science Trainees Advancing Through Research and Scholarship (STARS) program for the students underrepresented in the biomedical sciences (UBS). The trainees will participate in a cluster of rigorous skill and career development training programs, interdisciplinary research activities in biomedical subfields including molecular and developmental biology, microbiology biochemistry, genetics, neurotoxicology, epidemiology, and nutrition, and dissemination of research outcomes through this robust 3-year intensively-mentored program.

PI_NAMEs: ATKINS, MARDELLE RENEE (contact);HAINES, DONOVAN C;KHAN, KHALID M.

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Admission activity;Area;Awareness;Biochemistry;Bioinformatics;Biomedical Research;career;college;Computational Biology;Developmental Biology;disability;Doctor of Philosophy;Economics;Enrollment;Ensure;Environment;Epidemiology;Ethnic Origin;Evaluation;Event;experience;Faculty;flexibility;formative assessment;Gender;Genetic;Geography;Goals;improved;Inequity;Infrastructure;innovation;Interdisciplinary Study;Laboratories;Machine Learning;marginalized population;matriculation;Mentors;Mentorship;Microbiology;Mission;Molecular Biology;nutrition;Osteopathic Medicine;Preparation;prevent;programs;Race;Recruitment Activity;Research;Research Personnel;Research Project Grants;Research Training;Rotation;Scholarship;Science;skill acquisition;Social Mobility;student participation;Students;summer research;Supervision;Toxicology;Training;Training Activity;Training Programs;Translational Research;undergraduate research;undergraduate student;Underrepresented Students;United States;Universities

PROJECT_TITLE: U-RISE at Sam Houston State University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Nanotechnology;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Rehabilitation

ORG_CITY: ARLINGTON

ORG_NAME: NANOSCOPE TECHNOLOGIES, LLC

PHR: Retinitis Pigmentosa (RP) often results in legal blindness and is caused by more than 100 genetic mutations, making its development challenging to address all causes with gene therapy. We have screened and engineered mechanosensitive channels (EMC) from different microbial species, which upon expression in mammalian cells and retina, allows sonogenetic stimulation by ultrasound with intensity orders of magnitude lower than that required without EMC sensitization. Our sonogenetic stimulation-based approach will provide an alternative therapeutic modality to restore visual function in the degenerated retina.

PI_NAMEs: MOHANTY, SAMARENDRA KUMAR (contact);ZHOU, QIFA

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: Address;Animal Experimentation;Animals;base editing;Behavior assessment;Behavioral;Biodistribution;Biology;Biomedical Engineering;Biophotonics;Blindness;Cell Survival;Cells;Clinical Treatment;Closure by clamp;Combined Modality Therapy;Complex;constriction;Contact Lenses;Development;Devices;Disease Progression;DNA Sequence Alteration;Dose;Dose Limiting;efficacy evaluation;Electric Stimulation;Electrophysiology (science);Electroretinography;Elements;Engineering;Evaluation;experimental study;fabrication;Family suidae;Focused Ultrasound;Foundations;Frequencies;gene replacement;gene therapy;Genes;Goals;implantation;improved;In Vitro;in vivo;Injury;instrumentation;irradiation;Lasers;Legal Blindness;legally blind;Lipid Bilayers;Mammalian Cell;Measures;mechanical force;meter;microbial;Modality;Modeling;Molecular;mouse model;Mutation;nanoscope;Operative Surgical Procedures;Optical Coherence Tomography;Oryctolagus cuniculus;Pattern;photoreceptor degeneration;Photoreceptors;preference;pressure;Prosthesis;Rattus;Resolution;restoration;Retina;retinal damage;Retinal Degeneration;Retinal Ganglion Cells;retinal neuron;retinal prosthesis;retinal stimulation;Retinitis Pigmentosa;Rodent;RPE65 protein;Safety;sight restoration;Signal Transduction;Spottings;Stretching;Structure;success;Suction;Surgeon;System;systemic toxicity;Technology;Therapeutic;Toxic effect;Transducers;Translating;Translations;Ultrasonic Transducer;ultrasound;Vision;wearable device

PROJECT_TITLE: Sonogenetic Restoration of Vision for Retinitis Pigmentosa


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Electronic Nicotine Delivery Systems;Genetics;Heart Disease;Nutrition;Prevention;Tobacco

PHR: Project Narrative: In recent years, electronic cigarettes (e-cigarettes) use by youth has increased at a disturbing rate. We have shown that e-cigarettes induce cardiac dysfunction associated with DNA damage in a mouse model. In this R16 grant application, we are proposing to determine the effects of e-cigarette induced DNA damage and ultimately aid in developing effective medical therapies to prevent e-cigarette-induced cardiac dysfunction.

PI_NAMEs: ESPINOZA-DEROUT, JORGE  (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: acipimox;Adipose tissue;Adolescent;Affect;Anabolism;analog;Animals;Antioxidants;ApoE knockout mouse;Applications Grants;Area;Atherosclerosis;Autophagocytosis;Binding;Cardiac;Cardiac Myocytes;Cardiomyopathies;cofactor;combustible cigarette;comparison control;cytokine;Data;Deacetylation;detection of nutrient;Development;development policy;diet-induced obesity;Disadvantaged minority;DNA Damage;DNA damage checkpoint;Echocardiography;EFRAC;Electronic cigarette;electronic cigarette use;Elements;Energy Intake;Environment;Enzymes;Evaluation;Exposure to;Gene set enrichment analysis;Generations;Genes;Genetic;Heart;Heart failure;High Fat Diet;Homeostasis;Inflammatory;inhibitor;Laboratories;Lead;Left;Lipase;lipid biosynthesis;Lipids;Lipolysis;Los Angeles;Maintenance;Medical;Metabolic;Metabolic Diseases;Metabolic syndrome;Metabolism;Minority-Serving Institution;Mitochondria;mitochondrial dysfunction;Modeling;Monitor;mouse model;Mus;Myocardial dysfunction;Nicotine;Nicotinic Acids;Nonesterified Fatty Acids;overexpression;Oxidation-Reduction;Oxidative Stress;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phenotype;Play;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Polymerase;prevent;Production;Proteins;Publishing;Reactive Oxygen Species;Research;response;Role;Saline;Serum;Shortening Fraction;Signal Transduction;SIRT1 gene;Sirtuins;Site;Surveys;Testing;Therapeutic;Therapeutic Agents;therapeutic target;Therapeutic Uses;Tobacco use;transcriptomics;Transgenic Mice;Universities;Ventricular;Wild Type Mouse;Youth

PROJECT_TITLE: Targeting PARP Proteins in electronic cigarettes-induced cardiac dysfunction


ORG_CITY: HONOLULU

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE – Overall This COBRE-Diabetes Phase 2 grant will strengthen the center through further improvements in research infrastructure and the continued development of investigators at the Diabetes Research Center at the University of Hawaii at Manoa. In the US, approximately 11.3% of the population has diabetes and 38.0% are prediabetic. It is well known that the prevalence of diabetes disproportionately affects more racial and ethnic minorities such as Native Hawaiians, Pacific Islanders, Asians, among others.

PI_NAMEs: GERSCHENSON, MARIANA  (contact)

PROJECT_TERMS: Acceleration;Adult;Advisory Committees;Affect;Analytical Biochemistry;Animal Model;Animals;Area;Asian;Asian population;Basic Science;Bioinformatics;Biomedical Engineering;Biometry;Board Certification;Businesses;Cardiovascular Diseases;Career Mobility;Centers of Research Excellence;Childhood;Chronic Kidney Failure;Clinical;clinical epidemiology;Collaborations;collaborative environment;Communities;community engagement;Complications of Diabetes Mellitus;cost;Cultural Diversity;design;Development;Diabetes Mellitus;Diabetic Autonomic Neuropathy;disadvantaged background;Doctor of Philosophy;early-career faculty;Endocrinologist;Environment;Equipment;ethnic disparity;ethnic diversity;ethnic minority;ethnic minority population;Etiology;experience;Faculty;Fostering;Funding;Genomics;Goals;Grant;Hawaii;Health;health care disparity;health disparity;Heart Diseases;Hispanic;improved;In Vitro;in vivo;Institution;institutional capacity;Insulin Resistance;Interdisciplinary Study;Intervention Studies;Leadership;Link;medical schools;meetings;member;Mentors;Metabolic;metabolic abnormality assessment;Metabolic Diseases;Metabolism;minimally invasive;Minority;Modeling;National Institute of General Medical Sciences;National Institute on Minority Health and Health Disparities;Native Hawaiian;Native Hawaiian or Other Pacific Islander;Not Hispanic or Latino;Pacific Islander;Peer Review Grants;Persons;Phase;Physicians;Pilot Projects;Population;Prediabetes syndrome;Prevalence;professor;programs;racial disparity;racial minority;racial minority population;recruit;Research;research and development;research in practice;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Rodent;Science;Scientist;sensor;Series;Services;social media;Stroke;symposium;tenure track;Translational Research;United States National Institutes of Health;Universities;virtual;Visit;Vocational Guidance;web site;Writing

PROJECT_TITLE: COBRE-DIABETES

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-T (C2)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Diabetes

PROJECT_TERMS: Advisory Committees;Applications Grants;Area;career;Centers of Research Excellence;Clinical;Collaborations;Communities;community engagement;Data;Dedications;design;Development;Development Plans;diabetes management;Diabetes Mellitus;Doctor of Philosophy;Effectiveness;experience;Extramural Activities;Faculty;Funding;Future;Goals;Grant;Hawaii;improved;Individual;Infrastructure;Institution;instrumentation;Insulin Resistance;Leadership;Mentors;Metabolic;novel;peer;peer coaching;Peer Review;Phase;Pilot Projects;Prevention strategy;Principal Investigator;programs;Publications;Recommendation;recruit;Research;Research Personnel;Research Project Grants;Resources;Role;Scientist;social media;Students;success;symposium;Time;Training;unconscious bias;Universities;Update;Visit;web site;Writing

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Diabetes;Genetics;Nutrition

PHR: PROJECT NARRATIVE – Metabolic & Analytic Core Per instructions on FOA #PAR-23-063, this section should not be completed. See Overall section for information.

PI_NAMEs: LE SAUX, OLIVIER  (contact)

PROJECT_TERMS: Animal Model;Animals;Asian population;Autonomic Dysfunction;Bioinformatics;Bioinformatics Shared Resource;Biological Markers;Biometry;Burn injury;Cancer Center;Cardiac;career development;Cell model;Centers of Research Excellence;Cerebrovascular Disorders;Classification;Collaborations;college;Communities;Consultations;cost;Data Analyses;Databases;Dedications;design;Development;Diabetes Mellitus;DNA Methylation;Engineering;Epidemic;Equipment;equipment acquisition;Equipment and Supplies;Ethnic Origin;Evolution;Faculty;Fee-for-Service Plans;Fostering;Gene Expression;Genetic;Genomics;Goals;Grant;Growth;Hawaii;Hormones;Human;improved;in silico;In Vitro;in vivo;Infrastructure;Instruction;instrument;instrumentation;Interdisciplinary Study;interest;Kidney;Lead;Lipids;Literature;Measurement;Mediating;medical schools;member;Mentors;Metabolic;metabolic abnormality assessment;Metabolism;Microfluidic Microchips;Molecular;Molecular Profiling;Monitor;mouse model;mRNA Expression;multiple omics;Names;Native Hawaiian;Native Hawaiian or Other Pacific Islander;new technology;novel;Phase;Pilot Projects;Population;Predisposition;Protocols documentation;Recovery;recruit;Research;research and development;Research Personnel;Research Project Grants;Resources;Rodent Model;Schools;Science;Services;Skin;sustainable resource;System;Tissues;Training Activity;Training and Education;Universities;Variant

PROJECT_TITLE: Metabolic and Analytic Core


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Diabetes;Nutrition;Physical Activity;Prevention

PHR: PROJECT NARRATIVE – Research Project Leader: Tyler Ray, PhD An Epidermal Microfluidic Screening Panel for Diabetic Kidney Disease Per instructions on FOA #PAR-23-063, this section should not be completed. See Overall section for information.

PI_NAMEs: RAY, TYLER  (contact)

PROJECT_TERMS: Adherence;Affect;Athletic;Behavior;Biochemical;Biological Markers;Biometry;Blood Glucose;Calcium;Cellular Phone;Centers of Research Excellence;Chemical Stimulation;Chronically Ill;Clinical;Clinical assessments;Clinical Research;comorbidity;Continuous Glucose Monitor;Data;Data Reporting;design;Diabetes Mellitus;Diabetic Nephropathy;diagnostic tool;Disease;Disease Management;Doctor of Philosophy;Electrolytes;Environmental Risk Factor;Equipment;Exercise;exercise capacity;Glucose;Health;Health Status;Home;Hormones;Human;Hydration status;image processing;improved;Individual;Inflammatory;insight;Instruction;Intervention;Laboratories;laboratory facility;Measurement;Measures;Metabolic;Methodology;Methods;Microfluidic Microchips;Microfluidics;Monitor;Non-Insulin-Dependent Diabetes Mellitus;noninvasive diagnosis;novel;Outcome;patient population;Patient Self-Report;Patients;Performance;Physiological;Physiology;Potassium;precision medicine;Premature Mortality;prevent;Proteins;prototype;real time monitoring;Research Project Grants;response;Sampling;screening panel;sensor;Signal Transduction;Skin;Sodium Chloride;Specific qualifier value;Stress;Sweat test;Sweating;Techniques;temporal measurement;Testing;Therapeutic;therapeutic development;Time;tool;Urea;validation studies;Water;wearable device;wearable sensor technology;Work


NIH_SPENDING_CATS: Aging;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cerebrovascular;Diabetes;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurosciences;Nutrition;Obesity;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Stroke

PHR: PROJECT NARRATIVE – Research Project Leader: Stacy Brown, MD Association of Genetic Determinants of Diabetes with Cerebrovascular Disease in Multi-Ancestral Hawai'ian Populations Per instructions on FOA #PAR-23-063, this section should not be completed. See Overall section for information.

PI_NAMEs: BROWN, STACY C (contact)

PROJECT_TERMS: Age;ancestry analysis;Architecture;biobank;Blood Vessels;Centers of Research Excellence;cerebrovascular;Cerebrovascular Disorders;Clinical;Clinical Research;cohort;Cohort Studies;Communities;community engagement;Data;Databases;Derivation procedure;Diabetes Mellitus;diabetes risk;Diagnosis;Disease;Disparity population;Ensure;Epidemiology;epidemiology study;Ethnic Population;European;European ancestry;Event;exome;Frequencies;Future;Genetic;genetic architecture;Genetic Determinism;Genetic Polymorphism;Genetic Research;Genetic Risk;Genetic study;Genetic Variation;genome wide association study;Genomics;Genotype;Goals;Hawaiian population;Health;health disparity populations;Health system;Hyperlipidemia;Hypertension;Individual;Inequity;innovation;Institution;Instruction;instrument;Knowledge;Medical;Medical Genetics;Morbidity - disease rate;mortality;multi-ethnic;multidisciplinary;Native Hawaiian;Native Hawaiian or Other Pacific Islander;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Outcome;Pacific Islands;Participant;Performance;polygenic risk score;Population;Population Genetics;population health;Population Heterogeneity;precision medicine;preventive intervention;prospective;Public Health;Recovery;Research;Research Project Grants;Risk;Risk Factors;risk stratification;risk variant;Stroke;stroke risk;study population;Susceptibility Gene;Testing;Therapeutic Intervention;tool;Transient Ischemic Attack;translational genetics;Translational Research;Underrepresented Populations;Variant;Work

PROJECT_TITLE: Association of Genetic Determinants of Diabetes with Cerebrovascular Disease in a Multi-ancestral Hawaiian Population


NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Diabetes;Digestive Diseases;Heart Disease;Heart Disease - Coronary Heart Disease;Lung;Neurodegenerative;Neurosciences;Nutrition;Peripheral Neuropathy;Physical Activity;Prevention;Urologic Diseases

PHR: PROJECT NARRATIVE – Research Project Leader: Kathryn Schunke, PhD Diabetic Cardiomyopathy and Protection by Hypothalamic Parasympathetic Neuron Activation Per instructions on FOA #PAR-23-063, this section should not be completed. See Overall section for information.

PI_NAMEs: SCHUNKE, KATHRYN JAQUES (contact)

PROJECT_TERMS: Affect;airway obstruction;Algorithms;Animal Model;Animals;Antioxidants;Arrhythmia;Atherosclerosis;Autonomic Dysfunction;Autonomic nervous system;autonomic neuropathy;blood pressure reduction;Brain Stem;Cardiac;Cardiac pacemaker;Cardiomyopathies;cardioprotection;cardiovascular risk factor;Cardiovascular system;Caring;Cell Nucleus;Cells;Centers of Research Excellence;Chronic;Chronic Disease;Clinical;Clinical Research;Clinical Trials;comorbidity;Complex;Complication;Complications of Diabetes Mellitus;Conscious;Constipation;Data;designer receptors exclusively activated by designer drugs;Development;Diabetes Mellitus;Diabetic Autonomic Neuropathy;diabetic cardiomyopathy;Diarrhea;Disease;Disease Progression;Doctor of Philosophy;dorsal motor nucleus;Eating;Echocardiography;Enterobacteria phage P1 Cre recombinase;Epidemic;Equilibrium;Erectile dysfunction;Exclusion;Exercise;exercise intolerance;Exercise Tolerance;Fatty acid glycerol esters;Fecal Incontinence;Female;Fibrosis;Foundations;Fructose;Functional disorder;Future;Gastrointestinal tract structure;Gastroparesis;Gene Expression;Genitourinary system;Genomics;glucose tolerance;Glutamates;glycemic control;Growth;Heart;Heart failure;heart function;Heart Rate;Human;hypoglycemia unawareness;Hypothalamic structure;Impairment;improved;improvement on sleep;in vivo;Incidence;Inflammation;innovation;Instruction;instrument;Insulin Resistance;Knowledge;Left;Life;Life Style;loss of function;LoxP-flanked allele;male;Mediating;Mediator;Medical;mitochondrial metabolism;Modeling;Molecular;molecular phenotype;mortality;Myocardial;myocardial damage;Myocardial dysfunction;Myocardial Infarction;myocardial injury;Myocardial Ischemia;Nerve;Nerve Fibers;Neurogenic Bladder;Neurons;Neurosecretory Systems;neurotransmission;Nitric Oxide;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;nucleus ambiguus;Obesity;Obstructive Sleep Apnea;Orthostatic Hypotension;Oxytocin;paraventricular nucleus;Pathway interactions;Patients;Population;Prevalence;Quality of life;Rattus;Recording of previous events;Recovery;Research Project Grants;Rest;Risk;Risk Reduction;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;Sleep Apnea Syndromes;Sudden Death;Tachycardia;Telemetry;Testing;Therapeutic;therapeutic target;Tissues;Tracer;transcriptomics;translational potential;Vagus nerve structure;Ventricular;Viral Vector;Work


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: NORTHRIDGE

ORG_NAME: CALIFORNIA STATE UNIVERSITY NORTHRIDGE

PHR: Project Narrative G protein coupled receptors are therapeutic targets in a wide range of diseases and utilize G protein signaling for most of their effects. This project is aimed at using computational methods to understand the molecular mechanisms underlying G protein signaling. This provides fundamental knowledge about how these proteins work, which can help in the future in targeting their pathways for drug discovery.

PI_NAMEs: ABROL, RAVINDER  (contact)

PROJECT_TERMS: Adenylate Cyclase;ADRB2 gene;Adrenergic Agents;Affect;Agonist;Alanine;Area;Arrestins;AVPR2 gene;Binding;Binding Proteins;Biochemical;Biological Assay;Biophysics;Cardiovascular system;Cells;CNR1 gene;Complex;computer studies;Computing Methodologies;constitutive active receptor;Coupled;Couples;Coupling;Cryoelectron Microscopy;Cyclic AMP;Cytoplasm;Disease;Dissociation;Dopamine D1 Receptor;Dopamine D2 Receptor;drug discovery;Exhibits;experimental study;extracellular;Fluorescence Resonance Energy Transfer;Future;G alpha q Protein;G-Protein-Coupled Receptors;GTP Binding;GTP-Binding Protein Regulators;GTP-Binding Proteins;Guanine;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate;Heterotrimeric GTP-Binding Proteins;Hormones;Hybrids;Hydrolysis;Immune system;insight;Ion Channel;Kinetics;Knowledge;Letters;Ligands;Measures;Mediating;Membrane;Metabolic;Methods;Molecular;Molecular Conformation;molecular dynamics;Muscarinic M1 Receptor;mutant;Names;Nervous System;Neurotransmitters;Nucleotides;Pathway interactions;Phospholipase;Phosphotransferases;Photons;Physiological Processes;Play;Productivity;protein activation;Protein Conformation;Protein Dynamics;protein function;Proteins;receptor;receptor-mediated signaling;RGS Proteins;Role;Sampling;Signal Pathway;Signal Transduction;Signaling Protein;simulation;structural determinants;Structure;success;therapeutic target;Thermodynamics;Time;Transducers;transmission process;Work

PROJECT_TITLE: Structural dynamics and energy landscapes of G protein signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-X (SU)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Machine Learning and Artificial Intelligence

PHR: Project Narrative The U-M Center for Drug Repurposing seeks to enhance its high-content imaging capabilities through the acquisition of a Yokogawa CellVoyager 8000 and integrated robotics to serve the needs of a large number of NIH-funded laboratories. The resources of the U-M Center for Drug Repurposing are available to all researchers at U-M and will facilitate quantitative biological imaging and high-content screening.

PI_NAMEs: SEXTON, JONATHAN ZACHARY (contact)

PROJECT_TERMS: Address;assay development;Automation;Biological;Biological Assay;Biological Markers;biological research;biological systems;Cells;Cellular Morphology;Complex;Computer software;Data;data acquisition;deep learning;Development;disease model;drug discovery;drug repurposing;experience;experimental study;fluorescence imaging;Fluorescence Microscopy;Genetic;high throughput screening;Image;imaging platform;Immersion;In Vitro;Incubated;interest;Lasers;lens;machine vision;Mammalian Cell;Methodology;Methods;Microscope;microscopic imaging;Modality;Modeling;Morphology;Optics;Organoids;Patients;Pharmaceutical Preparations;Phenotype;Physiological;Resolution;robot control;Sampling;screening;System;technology platform;Testing;Therapeutic;tool;Water

PROJECT_TITLE: Laser-based high content imaging microscope

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-J (30)]


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cannabinoid Research;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Lung;Natural Products;Pediatric;Prevention;Rare Diseases;Substance Misuse;Tobacco

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND STATE UNIVERSITY

ORG_STATE: OR

PHR: The proposed project is relevant to public health because it aims to address gaps in knowledge concerning the poten�al harms of vaping manufactured cannabis products. The project is relevant to NIDA’s mission because it will aﬀord improved understanding of toxicant emissions that can aﬀect individual and public health.

PI_NAMEs: STRONGIN, ROBERT M (contact)

PROGRAM_OFFICER_NAME: HERRMANN, EVAN SULLIVAN

PROJECT_TERMS: Address;Adolescent;aerosolized;Aerosols;Affect;American;Cannabinoids;Cannabis;Characteristics;Chemicals;Chemistry;cohort;Consumption;Data;design;Devices;Disease Outbreaks;Electronic cigarette;evidence base;Formulation;Frequencies;Future;Gases;Generations;Goals;Harm Reduction;Health;High School Student;Immune system;improved;Individual;Knowledge;Legal;Link;Long-Term Effects;Lung;manufacture;marijuana use;marijuana vaping;Medical Marijuana;Methodology;Methods;Mission;Monitor;National Institute of Drug Abuse;Oils;Outcome;overdose risk;Patients;Persons;Plants;Poison;preadolescence;Prevalence;Production;psychologic;Psychoses;Public Health;Recreation;Regulation;Reporting;Risk;Route;Smoke;Smoking;Source;Surveys;synthetic cannabinoid;Teenagers;Temperature;Tetrahydrocannabinol;THC concentration;Toxic effect;toxicant;trend;vape pens;vaping;vaping associated lung injury;Vaporizer;Violence

PROJECT_TITLE: Emerging Trends in the Chemistry of Cannabis Vaping and Toxicant Emissions


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Social Determinants of Health

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Narrative / relevance to public health This project seeks to improve the training of next-generation biomedical engineers and entrepreneurs who will be developing technologies specifically to address unmet clinical needs. By immersing students in a clinical environment, providing them with mentorship from clinicians and industry veterans, and offering them with a pathway for commercializing their designs, we will be improving public health both in the near and long term.

PI_NAMEs: MALONEY, LAUREN MARIE;YIN, WEI  (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: Active Learning;Address;Applied Research;Arts;Biomedical Engineering;Biotechnology;Businesses;Cancer Education Grant Program;Clinical;Collaborations;college;commercialization;Communication;Communities;Consultations;Dental;Dental Schools;Dental Students;design;Development;Devices;Discipline;Discipline of Nursing;Education;education planning;Educational Activities;Educational Curriculum;Educational process of instructing;Emergency medical service;Engineering;Enrollment;Entrepreneurship;Environment;experience;Exposure to;faculty mentor;Fostering;Funding;Future;Generations;Goals;health equity;Health Occupations;Health Personnel;Health Sciences;Healthcare;improved;Industry;industry partner;Infrastructure;innovation;insight;Intellectual Property;interdisciplinary collaboration;Internships;job market;Journalism;Kenya;Laboratories;Language;Learning;local economy;Marketing;medical schools;Medical Students;Medicine;Mentors;Mentorship;New York;next generation;Nursing Faculty;Nursing Students;Occupational Therapy;Occupations;Outcome;Participant;Pathway interactions;Physical therapy;Process;programs;prototype;Public Health;Radiology Specialty;recruit;Renaissance;Resource-limited setting;Rural;School Nursing;Schools;Science;screening;Services;Side;skill acquisition;skills;Social Welfare;Structure;student participation;Students;success;Technology;Training;Translations;undergraduate education;undergraduate student;United States National Institutes of Health;Universities;University Hospitals;Veterans;Work;Workforce Development

PROJECT_TITLE: Development of an enhanced biodesign curriculum to promote biomedical innovation

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-G (J1)]


ADMINISTERING_IC: CK

IC_NAME: National Center for Emerging and Zoonotic Infectious Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE International travel may not only increase the risk of infection for an individual traveler, but may also contribute to the global spread of infections. This continuation application focuses on Global TravEpiNet -- a consortium of clinics providing pre-travel health advice, the driving force behind the Heading Home Healthy Program, and a platform for quantitative assessments of travel-related illnesses and interventions. GTEN’s mission is to advance the care of U.S. international travelers, with the goal of preserving and advancing the health of the American public.

PI_NAMEs: LAROCQUE, REGINA C (contact);RYAN, EDWARD T.

PROJECT_TITLE: CK21-001 - Global TravEpiNet (GTEN): U.S. Travelers' Health Research, Surveillance, Communication and Outreach Network Supplement


ORG_CITY: SUNNYVALE

ORG_NAME: MISSION RABIES USA, INC.

PHR: Project Narrative Our generation has an opportunity to unite human and animal health services in One Health initiatives to eliminate dog-transmitted rabies; a disease which drives societal inequality in low to middle income countries. Poor quality data in most rabies endemic countries clouds evidence-based policies and hampers successful control measures. This research programme drives a step change in the use of technological innovation to enhance the strategic planning, large-scale implementation and robust evaluation of dog rabies elimination strategies.

PI_NAMEs: GAMBLE, LUKE  (contact)

PROJECT_TITLE: RFA-CK-22-002, Adaptation and assessment of smartphone technology to improve the implementation and evaluation of One Health systems for rabies control and surveillance globally


ADMINISTERING_IC: OH

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative There is a critical shortage of physicians formally trained in occupational and environmental medicine (OEM) at a time of escalating workplace and environmental hazards and exposures, highlighted by the current COVID-19 pandemic. This NIOSH TPG proposal describes the Yale OEM residency program, a long-standing highly successful and stable ACGME-accredited NIOSH-supported PM / OEM residency training program with the goal of training future OEM physician leaders in a range of OEM academic, public service and practice careers. The training program continues to evolve to train OEM physicians to address the substantial challenges U.S. workers and employers will face in the future.

PI_NAMEs: REDLICH, CARRIE A (contact)

PROJECT_TITLE: Yale Occupational and Environmental Medicine Residency Training Program


ED_INST_TYPE: SCH OF BUSINESS/PUBLIC ADMIN

ORG_CITY: MENOMONIE

ORG_DEPT: ADMINISTRATION

ORG_NAME: UNIVERSITY OF WISCONSIN STOUT

ORG_STATE: WI

PHR: See program plan under PHS 398 Research Training Program Plan

PI_NAMEs: FINDER, BRIAN JAMES (contact)

PROJECT_TITLE: UW-Stout M.S. Risk Control and Safety Management Program Enhancement


ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: The Graduate Training Program in Occupational Health Psychology (OHP) at the University of Connecticut (UConn) recruits qualified doctoral-level graduate students in industrial/organizational psychology, nursing, public health, and occupational and environmental medicine for specialized training in occupational health psychology (OHP). Trainees learn how to contribute to the OHP knowledge base and become highly capable at discovering or implementing new ways of maintaining and promoting worker health and safety. The training program entails a combination of course content and applied research training that is designed not only to equip trainees with the necessary skills to address today's occupational health problems, but also to enable them to introduce new concepts of work organization and workplace design that can enhance worker safety, health and productivity through proactive approaches to workplace interventions.

PI_NAMEs: MAGLEY, VICKI J (contact)

PROJECT_TITLE: Occupational Health Psychology Training


ADMINISTERING_IC: DP

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative NYC CONNECT (New York City Cancer Outreach Network in Neighborhoods for Equity and Community Translation) will build on an existing community-based community-clinical linkage patient navigator program for cancer screening and treatment. We will work together with diverse community and clinical partners to identify and incorporate racial equity strategies to address systemic racism into the program in order to improve cancer prevention and screening outcomes among racial and ethnic minority and immigrant communities.

PI_NAMEs: RAPKIN, BRUCE D;TRINH-SHEVRIN, CHAU  (contact)

PROJECT_TITLE: DP21-003 NYC Cancer Outreach Network in Neighborhoods for Equity and Community Translation


ADMINISTERING_IC: DD

IC_NAME: NATIONAL CENTER ON BIRTH DEFECTS AND DEVELOPMENTAL DISABILITIES

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE This study will shed light on a wide variety of genetic, prenatal, early-life and family factors that influence the risk for autism spectrum disorder (ASD) and on differences and similarities in the behaviors, abilities, and health of preschoolers with ASD. It will also provide insights into the experiences of adolescents with ASD as they mature. By helping to explain the causes of ASD and how ASD affects children, youth and young adults, this project will contribute to efforts to reduce the risk of ASD and improve the outcomes of affected children.

PI_NAMEs: DIGUISEPPI, CAROLYN G (contact)

PROGRAM_OFFICER_NAME: OGUNFUYI, SHAKIRATU BIOLA

PROJECT_TITLE: Colorado SEED Component A & Component B


ADMINISTERING_IC: PS

IC_NAME: NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STD AND TB PREVENTION

ORG_NAME: AMIDA CARE INC.

PHR: Project Narrative CDC PS-21-004 This proposed project develops, implements, and evaluates a collaborative “Data-to- Care Rx” model using pharmaceutical insurance claims data to identify persons with HIV in real-time who fail to pick up prescribed ARV medications by 30 days and 60 days, and to implement targeted evidence-based interventions at each of these benchmarks in an effort to address adherence barriers and re-engage these individuals in HIV medication therapy and primary care. This Data-to-Care collaboration is made up of four partnering organizations that will collaborate with the Centers for Disease Control and Prevention (CDC) – Amida Care (AC), Cicatelli Associates, Inc. (CAI), the Brookdale Center for Healthy Aging at Hunter College of the City University of New York (CUNY), and the New York State Department of Health (NYSDOH) AIDS Institute.

PI_NAMEs: ANTONIOS, VERA  (contact)

PROJECT_TITLE: RFA-PS-21-004: Using Real-time Prescription Data to Support HIV Care and Treatment Adherence in NYC


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

ORG_CITY: LOWELL

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF MASSACHUSETTS LOWELL

PHR: Public Health Relevance Epidemiology and ergonomics are two fundamental disciplines of occupational safety and health. The occupational ergonomist is concerned with identifying potential health hazards affecting the musculoskeletal, cardiovascular, mental/emotional, or other body systems, so an understanding of the epidemiologic evidence is essential. The occupational epidemiologist must appreciate the importance of exposure assessment – whether biomechanical, physical, chemical, or psychosocial - in order to characterize dose-response relationships and assess the effectiveness of interventions; and must have a sophisticated methodologic toolbox in order to unpack questions of public interest such as the health effects of prolonged sitting vs standing, population stress related to the changing nature of work, or the potential impact of occupational injury on opioid use.

PI_NAMEs: BUCHHOLZ, BRYAN O (contact)

PROJECT_TITLE: Occupational  Health and Safety Training Grant


ORG_NAME: CICATELLI ASSOCIATES, INC.

PHR: Project Narrative Reducing Cancer Disparities within the Black community in Jackson, MS through Community-Led Tobacco- Related Social Norm Change will evaluate Project BAT (Black people Against Tobacco), an ongoing community-led intervention to empower low-income African American and Black communities to change social norms around tobacco utilization and promote optimal health and cancer prevention throughout the community. There is broad understanding of the function of norms around tobacco use as well as what the threshold for “tipping points” of norms generally are, but the impact of using a community-engaged model to drive social norm change among Black and minority communities remains unexamined. Through our proposed rigorous evaluation of Project BAT, which addresses the myriad environmental factors that contribute to tobacco use, we seek to demonstrate to the research community that social norms change is achievable through community-based action.

PI_NAMEs: ROGERS, ERIN ;SENTER, LINDSAY  (contact)

PROJECT_TITLE: DP21-003 Reducing Cancer Disparities within the Black community in Jackson, MS through Community-Led Tobacco-Related Social Norm Change


ORG_CITY: BLACKSBURG

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Public Health Relevance Statement This application proposes a continuation of our Training Project Grant at Virginia Tech, begun in 1992. Our proposed training focuses on safety engineering, occupational ergonomics, and occupational biomechanics, and supports both regional and national needs for practitioners and researchers in these domains.

PI_NAMEs: NUSSBAUM, MAURY A (contact)

PROJECT_TITLE: Occupational Ergonomics and Safety Training


ORG_CITY: MILLERSVILLE

ORG_NAME: MILLERSVILLE UNIVERSITY

PHR: Project Narrative Funds requested will be used to provide tuition and fees support to students pursuing a baccalaureate degree in Occupational Safety & environmental Health (OSEH). Approximately 98% of the trainees enter the OS&H workforce upon graduation.

PI_NAMEs: OGUTU, JACK  (contact)

PROJECT_TITLE: Millersville University NIOSH Training Program Grant


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE  Vascular cognitive impairment and dementia (VCID) is the second most common cause of dementia after Alzheimer’s disease (AD), and development of effective therapies is urgently required. The object of this application is to investigate the key role of a long non-coding RNA, Malat1, in the regulation of long-term cognitive functions, brain white matter integrity, and neuronal loss in experimental VCID. The successful implementation of this proposal will elucidate the molecular mechanism of Malat1-mediated vascular brain injury and may eventually lead us to discover novel long non-coding RNA-based therapies for the treatment of VCID.

PI_NAMEs: YIN, KEJIE  (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Acute;Adherens Junction;Alternative Splicing;Alzheimer's Disease;Biological Process;Blood Vessels;blood-brain barrier permeabilization;Brain;brain endothelial cell;cadherin 5;CCL2 gene;cell motility;Cell Proliferation;cerebral hypoperfusion;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;cerebrovascular pathology;Cerebrovascular system;Cerebrovascular Trauma;chromatin remodeling;Chronic;Cognition Disorders;cognitive function;cytokine;Dementia;deprivation;Development;Diffuse;Dosage Compensation (Genetics);E-Selectin;Economics;effective therapy;Endothelial Cells;Endothelium;Epigenetic Process;Functional disorder;Gene Expression;Gene Modified;Genetic;Genomic Imprinting;Glucose;gray matter;Growth;hemodynamics;human disease;immune cell infiltrate;Impaired cognition;improved;Inflammation;Inflammatory;Injury;Intravenous;Ischemic Brain Injury;ischemic injury;MALAT1 gene;Malignant Neoplasms;Mediating;Molecular;mouse model;Mus;myogenesis;Nervous System Disorder;neuron loss;Non-Small-Cell Lung Carcinoma;novel;Organogenesis;overexpression;Oxygen;Pathogenesis;Pathologic;Physiological Processes;Play;preservation;prevent;protein expression;Proteins;Regulation;Research;Rodent;Role;social;Societies;stroke model;synaptogenesis;therapeutic RNA;therapeutic target;therapeutically effective;Tight Junctions;Transgenic Organisms;Untranslated RNA;vascular cognitive impairment and dementia;vascular contributions;white matter;white matter injury

PROJECT_TITLE: Long non-coding RNAs mediate white and grey matter integrity in vascular cognitive impairment and dementia

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Pediatric

PHR: Narrative This project aims to understand better the neural mechanisms underlying the critical period changes that occur from adolescence to adulthood that support improvements in working memory using the non-invasive method of EEG on a normative sample and the invasive approach of direct neural measures using sEEG in healthy brain regions of epilepsy resection patients. This information will be integrated into a computational model of neocortical circuitry to elucidate the microlevel changes in brain processing that supports the transition from adolescence to adulthood when trajectories are established. Understanding normative brain changes during this developmental period is a critical first step to assessing impaired development that can lead to psychopathology, which predominantly emerges in adolescence (e.g., psychosis, mood disorders, substance use disorders).

PI_NAMEs: MCKEON, SHANE  (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Adolescence;Adolescent;adolescent brain development;Adolescent Development;Adult;Age;age related changes;Animal Model;Autopsy;Biomedical Engineering;Brain;Brain region;Cells;childhood epilepsy;Clinical;Cognitive;cognitive control;cognitive development;cognitive function;cognitive neuroscience;Computer Models;Coupling;critical period;Data;Data Collection;design;Development;Electroencephalography;Engineering;Epilepsy;Equilibrium;Event;Excision;executive function;Feedback;gamma-Aminobutyric Acid;Glutamates;Human;human model;Impairment;improved;Individual;insight;Interneurons;Knowledge;Letters;life span;Link;magnetic resonance spectroscopic imaging;Magnetism;Measurable;Measures;Mediating;Mental Health;Methodology;Methods;Modeling;Mood Disorders;multimodal neuroimaging;multimodality;Nature;neocortical;neural;neurobiological mechanism;Neurobiology;Neurocognitive;neuromechanism;Neurons;Neurophysiology - biologic function;neuropsychiatric disorder;Neurosciences;Neurotransmitters;novel;oral communication;Participant;Parvalbumins;Patients;Performance;Prefrontal Cortex;Process;Psychiatry;Psychopathology;Psychoses;Research Personnel;research study;response;Sampling;Scanning;Short-Term Memory;Signal Transduction;spectroscopic imaging;Substance Use Disorder;Sum;Support System;Synapses;synaptic pruning;Techniques;temporal measurement;Time;transition to adulthood;ward;Work;Writing

PROJECT_TITLE: Brain Mechanisms Underlying Changes in Neural Oscillations through Adolescent Cognitive Maturation


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: SALT LAKE CITY

ORG_NAME: VA SALT LAKE CITY HEALTHCARE SYSTEM

ORG_STATE: UT

PHR: Project Narrative Polycythemia vera (PV) and essential thrombocythemia (ET) are forms of chronic leukemia caused by mutations in bone marrow cells (stem cells) that generate all types of blood cells including red cells, white cells and platelets. Patients with PV have too many red blood cells and patients with ET have too many blood platelets. Unlike the cells of other types of cancer, the blood cells in PV and ET look normal. What makes people with PV and ET sick, causing hospitalization and even premature death, are blood clots (thromboses). In this proposed research, we want to understand why patents with PV and ET have more blood clots. We intend to extend our recently published work and define the molecular mechanism of thromboses in more detail, hoping it will lead to a better understanding of the mechanism of thromboses in PV and ET and to new and better treatment.

PI_NAMEs: PRCHAL, JOSEF T (contact)

PROJECT_TERMS: Adult;Blood;Blood Cell Count;Blood Cells;Blood coagulation;Blood Platelets;Bone Marrow Cells;calreticulin;cancer type;Cell Line;Cells;Cessation of life;Child;Chronic Leukemia;Clinical;cofactor;Colony-forming units;Congenital Disorders;Data;Development;Disease;EDN1 gene;Endothelial Cells;Endothelium;Environment;Enzymes;Erythrocytes;Erythrocytoses;follow-up;Gene Expression;Genes;Genetic Transcription;Goals;granulocyte;Hematocrit procedure;Hematopoietic;Hematopoietic Neoplasms;Hemorrhagic Thrombocythemia;Home;Hospitalization;Hypoxia;hypoxia inducible factor 1;Incidence;Inflammation;Inflammatory;inhibitor;interest;Iron;iron deficiency;JAK1 gene;JAK2 gene;Laboratory Finding;Legal patent;Leukocytes;Mediating;Messenger RNA;Molecular;monocyte;Morbidity - disease rate;mortality;MPL gene;Multivariate Analysis;Mutate;Mutation;Myeloproliferative disease;neutrophil;new therapeutic target;novel;Patients;Persons;Physicians;Play;Polycythemia;Polycythemia Vera;premature;prevent;Prevention;Procollagen-Proline Dioxygenase;prospective;Protein S;Publishing;Recording of previous events;Registries;Regulation;Research;Risk;Role;Signal Transduction;Somatic Mutation;Source;stem cells;Testing;Thromboplastin;Thrombosis;thrombotic;Transcript;transcription factor;Up-Regulation;Venous blood sampling;Venous Thrombosis;VHL mutation;White Blood Cell Count procedure;Work;Zinc Fingers

PROJECT_TITLE: Mechanism of thrombosis in two myeloproliferative neoplasms (MPNs), polycythemia vera and essential thrombocythemia


NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome;Nanotechnology;Prevention

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Older adults who take medications that cause dry mouth suffer from aggressive caries progression, especially in the roots of teeth. An innovative treatment has been developed to boost the effect of fluoride by the use of fluoride-releasing nanoparticles engineered to penetrate and bind to the cariogenic dental plaque. The high fluoride level induced in dental plaque by this treatment, without increasing the level of exposure to the ion, can reduce root caries progression in individuals with dry mouth.

PI_NAMEs: ANDALO-TENUTA, LIVIA MARIA (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Acids;Address;Adult;Affect;Aging;aging population;Animals;anticaries;Artificial nanoparticles;Bacteria;bacterial metabolism;Binding;Buffers;Calcium Fluoride;Caries prevention;cariogenic bacteria;Charge;Chitosan;Clinical effectiveness;demineralization;dental biofilm;Dental caries;Dental Plaque;Dentin;Deterioration;Development;Diabetes Mellitus;Disease;Dose;Drops;dysbiosis;Eating;Electrostatics;Exhibits;Exposure to;Fluorides;frailty;Goals;Health;high risk;human old age (65+);Hypertension;Impairment;improved;In Vitro;in vivo;in vivo evaluation;Individual;innovation;Ions;Lesion;Microbial Biofilms;Minerals;Modeling;mortality;nanoparticle;Neurodegenerative Disorders;novel therapeutics;nutrition;older adult;Older Population;Oral;oral biofilm;Oral health;Outcome;Pain;Patients;Penetration;Pharmaceutical Preparations;Pilot Projects;Predisposition;Prevalence;Preventive;Preventive treatment;Production;Quality of life;Research;Risk;Rodent;Root Caries;Safety;Saliva;Salivary;Social Functioning;standard of care;Surface;systemic toxicity;Technology;Testing;Therapeutic;Therapeutic Uses;Time;Tooth Loss;Tooth root structure;Tooth structure;Toothpaste;United States;Work;Xerostomia

PROJECT_TITLE: Enhancing the effect of fluoride for root caries control in high-risk older adults (Resub)


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Lung;Orphan Drug;Pulmonary Hypertension;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: NARRATIVE The experiments in this proposal will explore cellular mechanisms involved in the development of pulmonary arterial hypertension (PAH), a devastating disease with limited treatment options. In particular, we will explore whether specific protein-protein interactions featuring MK2, caspase-3 and aquaporin 1 mediate changes in endothelial cell phenotype that contribute to vascular remodeling during development of PAH and that can be targeted to reverse remodeling. Such information is crucial to advancing treatment and developing new therapeutic options for this deadly disease.

PI_NAMEs: DAMARLA, MAHENDRA ;SHIMODA, LARISSA A. (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Apoptosis;Apoptotic;AQP1 gene;Blood capillaries;C-terminal;CASP3 gene;Cell Death;cell growth;Cell Physiology;Cell Survival;Cells;Complex;Consensus;Coupled;Cytosol;Data;Development;Disease;Down-Regulation;Endothelial Cells;experimental study;Exposure to;Failure;Family;Growth;Hypoxia;Hypoxia Inducible Factor;Immunoprecipitation;In Vitro;in vivo Model;inhibitor;insight;interdisciplinary approach;Laboratories;Lesion;Link;lung hypoxia;lung injury;lung microvascular endothelial cells;MAPKAPK2 gene;Mediating;Membrane Proteins;Modeling;Molecular;Molecular Chaperones;Mus;novel;novel therapeutics;Nuclear;Nuclear Translocation;Pathogenesis;Pathway interactions;Patients;Phenotype;Play;Predisposition;prevent;Proliferating;protein expression;protein protein interaction;Protein-Serine-Threonine Kinases;Proteins;Publishing;pulmonary arterial hypertension;pulmonary arterial pressure;Pulmonary arterial remodeling;Pulmonary Hypertension;pulmonary vascular cells;Rattus;Regulation;Resistance;right ventricular failure;Rodent Model;Role;Signal Pathway;Site;Stimulus;Stress;SU 5416;Tail;Testing;therapeutic target;transcription factor;Ubiquitination;Up-Regulation;Vascular Proliferation;Vascular remodeling;water channel

PROJECT_TITLE: MK2 and pulmonary hypertension

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_DEPT: PATHOLOGY

PHR: For this application, we have obtained strong preliminary data identifying biomarkers of ovarian cancer that can determine presence of disease 12 months before clinical diagnosis. We propose to construct a biomarker algorithm and validate its performance for identification of ovarian cancer at the early stages using samples collected as a part of the Nurses' Health Study (NHS), and UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) cohorts. Biomarkers that pass this and subsequent validation steps could significantly shift the stage of ovarian cancer at diagnosis and reduce ovarian cancer mortality and patient care costs.

PI_NAMEs: BAST, ROBERT C;LOKSHIN, ANNA E. (contact)

PROGRAM_OFFICER_NAME: PATRIOTIS, CHRISTOS F

PROJECT_TERMS: Algorithms;Autoantibodies;Biological Markers;biomarker identification;biomathematics;blood-based biomarker;CA-125 Antigen;cancer biomarkers;cancer survival;candidate marker;care costs;Classification;classification algorithm;clinical diagnosis;clinical practice;Clinical Trials;cohort;collaborative trial;Combination Drug Therapy;Complement;Computer Models;Consensus;Data;Death Rate;Detection;Development;Diagnosis;Diagnostic;diagnostic value;Disease;early detection biomarkers;Early Diagnosis;Epithelial ovarian cancer;feasibility testing;follow-up;Goals;improved;Interdisciplinary Study;Intervention;Lead;Low Prevalence;Malignant neoplasm of ovary;Measurement;Measures;Modality;Modeling;mortality;novel;Nurses' Health Study;operation;Patient Care;Patients;Performance;Population;population based;Postmenopause;pre-clinical;Predictive Value;Probability;prospective;Prospective Studies;Qualifying;Recommendation;Resistance;Risk;Sampling;screening;Screening for Ovarian Cancer;Serum;Specificity;Survival Rate;Symptoms;Testing;Time;treatment response;tumor;Tumor Debulking;Ultrasonography;United Kingdom;United States Preventative Services Task Force;Vagina;Validation;Woman

PROJECT_TITLE: Development of Novel Ovarian Cancer Biomarkers for Early Detection Algorithms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-H(02)M]