ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: Glioblastoma multiforme (GBM) is a highly aggressive brain tumor associated with extremely poor prognosis and survival. Although relatively rare in the US general population, GBM is the third most common cause of cancer death in the US active-duty military. Increased GBM incidence in US Veterans has been attributed to the toxic exposures to Agent Orange in Vietnam and burn pits in Iraq and Afghanistan. Despite significant advances in GBM therapy, the 5-year survival is only 7.2% in the United States. These existing treatment challenges highlight an urgent need for novel therapeutic strategies targeting therapy-resistant cancer subpopulations. Identification and selective targeting of tumor cells, which are resistant to current therapy, may ultimately lead to successful abrogation of clinical tumor growth and improve the quality of life and survival of patients suffering from GBM.

PI_NAMEs: FRANK, NATASHA Y (contact)

PROJECT_TERMS: active duty;Afghanistan;agent orange;angiogenesis;Angiogenesis Inhibitors;Apoptosis;Apoptotic;axl receptor tyrosine kinase;Binding;Blood - brain barrier anatomy;Brain Neoplasms;burn pit;Cancer Control;Cancer Etiology;cancer stem cell;Cell Cycle Arrest;Cell Cycle Regulation;Cell Maintenance;Cell membrane;Cell Physiology;Cessation of life;chemotherapy;Clinical;clinically relevant;Colon Carcinoma;Colorectal Cancer;DDR1 gene;Development;DNA;DNA Repair;Drug resistance;Enhancers;Epigenetic Process;epigenetic regulation;epigenome;Epithelium;Etiology;Evolution;Excision;Exposure to;Feedback;G2/M Arrest;General Population;Genes;Glioblastoma;Heterogeneity;Human;Immunotherapeutic agent;Impairment;improved;in vitro Model;in vivo;Incidence;inorganic phosphate;Interruption;Invaded;Iraq;knockout gene;Laboratories;leukemia;Malignant - descriptor;Malignant Breast Neoplasm;malignant mouth neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Mediator;Melanoma;member;Membrane;Membrane Proteins;Mesenchymal;Military Personnel;Modality;Monoclonal Antibodies;Multi-Drug Resistance;Nature;Neoplasm Metastasis;neoplastic cell;new therapeutic target;Normal tissue morphology;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Pathway interactions;Patients;Phenotype;Phosphatidylinositol 4,5-Diphosphate;phosphatidylinositol receptor;Phosphatidylinositols;Phosphorylation;Physiological;PI3K/AKT;PIK3CG gene;pluripotency;Primary carcinoma of the liver cells;Production;Prognosis;Quality of life;Radiation;receptor;Receptor Protein-Tyrosine Kinases;recruit;Recurrence;Refractory;refractory cancer;Regulation;Repression;Resistance;response;self-renewal;Signal Pathway;Signal Transduction;stem cell biomarkers;stem cell self renewal;stem cells;success;targeted treatment;temozolomide;Testing;Therapeutic;therapy resistant;Toxicant exposure;tumor;tumor growth;tumor heterogeneity;tumor progression;Tumor Stem Cells;tumor-immune system interactions;United States;Vascular Endothelial Growth Factor Receptor-1;Veterans;Vietnam

PROJECT_TITLE: Targeting therapeutic resistance in glioblastoma


ADMINISTERING_IC: VA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

ORG_STATE: PA

PHR: Trans-arterial chemoembolization (TACE) is the most commonly used therapy for patients with unresectable hepatocellular carcinoma (HCC). TACE is a minimally invasive procedure that involves placing a catheter into the artery in the liver that feeds the tumor, administering chemotherapeutics and then blocking the artery with embolics in order to kill tumor cells by depriving them of essential oxygen and nutrients. While TACE has a proven survival benefit, local recurrence is common, and long-term survival rates are poor. Prior studies demonstrate that HCC cells survive the oxygen and nutrient deprivation through autophagy, a process of cellular self- eating, to provide nutrients required for survival. The proposed project will leverage this dependency to develop a novel approach to TACE that integrates autophagy inhibition to improve therapeutic response by increasing tumor cell killing and enhancing anti-tumor immunity.

PI_NAMEs: GADE, TERENCE P (contact);KAPLAN, DAVID E

PROJECT_TERMS: Achievement;Ammonia;anti-tumor immune response;Arterial Embolization;Arteries;Autophagocytosis;biological adaptation to stress;Biology;Biopsy;Blood Vessels;Cancer Etiology;cancer therapy;Catheters;cell killing;Cell Physiology;Cell Survival;Cells;Cessation of life;Chemoembolization;Chemoresistance;chemotherapeutic agent;chemotherapy;Clinical;Clinical Trials;Combined Modality Therapy;cytotoxic;cytotoxicity;Data;Dependence;deprivation;Disease;Dose;Eating;epigenetic silencing;Evolution;Excision;Extensive Necrosis;Feeds;first-in-human;follow-up;General Population;Goals;Granzyme;Growth;Hepatic artery;Hepatocyte;Hepatotoxicity;Histologic;Histopathology;Hydroxychloroquine;Image;image guided;image guided therapy;Immune;Immune response;immunoregulation;improved;improved outcome;In Vitro;in vivo;inhibition of autophagy;inhibitor;Interruption;Intra-Arterial Infusions;Ischemia;Liver;liver transplantation;Maintenance;Malignant Epithelial Cell;Malignant Neoplasms;Metabolic;Metabolic Activation;metabolic phenotype;Metabolic stress;minimally invasive;Molecular;Necrosis;neoplastic cell;new therapeutic target;novel;novel strategies;Nutrient;nutrient deprivation;Nutritional Requirements;Operative Surgical Procedures;Oral;Oxygen;Pathology;patient population;Patients;Pattern;perforin;Phase;Phenotype;Portal vein structure;Primary carcinoma of the liver cells;Procedures;Progression-Free Survivals;prospective;Randomized;Recurrence;response;Safety;safety assessment;Sampling;Serum;standard of care;Survival Rate;T cell clonality;Testing;Therapeutic;Therapeutic Embolization;Transplantation;treatment response;tumor;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;Unresectable;urea cycle;Vascular blood supply;Veterans;Work

PROJECT_TITLE: Targeting Ischemia-Induced Autophagy Dependence in hepatocellular Carcinoma through Image-guided Locoregional Therapy


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Disorders;Breast Cancer;Cancer;Estrogen;Neurosciences;Prevention;Women's Health Research

ORG_CITY: Aurora

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Defining how estrogens modulate the brain niche and promotes metastatic colonization is urgently needed to change the treatment paradigm and prognosis in younger women at high risk of brain metastasis, thus, it is highly relevant to public health.

PI_NAMEs: CITTELLY, DIANA M. (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: Adult;Anti-Inflammatory Agents;Aromatase;Aromatase Inhibitors;Astrocytes;Automobile Driving;Blocking Antibodies;Brain;Brain imaging;Brain Neoplasms;Brain-Derived Neurotrophic Factor;cancer cell;cancer complication;Cancer Patient;Cell Line;Cells;chemokine;Clinical;conditional knockout;Data;Disseminated Malignant Neoplasm;EGF gene;Enzymes;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;ERBB2 gene;ESR1 gene;Estradiol;Estrogen Receptor 2;Estrogen receptor negative;Estrogen receptor positive;Estrogens;Genes;Genetic;Glial Fibrillary Acidic Protein;Goals;Growth Factor;high risk;High Risk Woman;Immunologic Surveillance;In Vitro;in vivo;inhibitor;innovation;Knockout Mice;Letrozole;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Metastatic malignant neoplasm to brain;Microglia;Modeling;mouse model;Neoplasm Metastasis;Neurons;neuroprotection;Neurosciences;neurotrophic factor;novel;novel strategies;NTRK2 gene;Ovarian;Ovarian hormone;Ovariectomy;Pathway interactions;patient derived xenograft model;pharmacologic;Phenotype;Play;preclinical efficacy;Premenopause;prevent;Prevention;Prognosis;Public Health;recruit;Repression;Resistance;response;Role;Sampling;Signal Transduction;Site;Specimen;Testing;Therapeutic;Thinking;tool;trait;Transgenic Mice;tumor;Tumor Suppressor Proteins;tumorigenesis;Up-Regulation;young woman

PROJECT_TITLE: Mechanisms underlying pro-metastatic effects of estrogen in the brain niche


ADMINISTERING_IC: HL

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cardiovascular;Nanotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ARLINGTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF TEXAS ARLINGTON

ORG_STATE: TX

PHR: NARRATIVE Peripheral arterial disease (PAD), an illness commonly found in the elderly and caused by arterial occlusion in the lower body, affects more than 200 million people worldwide and is associated with high rates of morbidity and mortality. To reduce these complications and improve the quality of life for PAD patients, our research aims to develop novel biodegradable nanoparticles to deliver therapeutic agents that specifically protect cells under ischemic stress conditions, facilitate the formation of blood vessels under hypoxia, and facilitate noninvasive multimodal imaging methods, such as fluorescent and photoacoustic imaging, to monitor the progress of this therapeutic intervention. The impact of our research is significant as these new nanoparticle platforms could be used to deliver any therapeutics locally, treat this disease effectively, and monitor the treatment noninvasively by imaging.

PI_NAMEs: MASON, RALPH P.;NGUYEN, KYTAI TRUONG (contact);YAN, SU

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Acute;Affect;Aftercare;Alternative Therapies;angiogenesis;Aniline;Animal Model;animal model selection;antibody conjugate;Apoptosis;Arteries;artery occlusion;Binding;Biocompatible Materials;Biodistribution;biomaterial compatibility;Blood coagulation;Blood flow;Blood Glucose;blood perfusion;blood vessel development;Blood Vessels;CD34 gene;Cell Survival;Cells;Cholesterol;Chronic;Collateral Circulation;combat;common treatment;Complementary DNA;Cytoprotection;Data;Death Rate;Detection;Development;Diarrhea;Disease;effective therapy;effectiveness evaluation;elastomeric;Elastomers;Elderly;endothelial stem cell;Erythropoietin Receptor;Evaluation;fabrication;femoral artery;fluorescence imaging;gene therapy;Goals;Growth Factor;Headache;Hemorrhage;Hypertension;Hypoxia;imaging modality;imaging properties;Impairment;improved;In Situ;In Vitro;in vivo;in vivo evaluation;Individual;Induction of Apoptosis;Inflammation;innovation;Intervention;Intramuscular;Ischemia;Leg;Ligation;limb ischemia;limb loss;Location;Lower Extremity;Mediating;Modality;Monitor;Morbidity - disease rate;mortality;mouse model;Multimodal Imaging;Names;nanoparticle;Nanotechnology;non-invasive imaging;novel;novel therapeutics;Obstruction;Operative Surgical Procedures;Pain in lower limb;Patients;Peripheral;Peripheral arterial disease;Persons;Pharmaceutical Preparations;Pharmacotherapy;photoacoustic imaging;Polymers;Predisposition;prevent;Property;Quality of life;Reagent;recruit;reduce symptoms;Research;Research Project Grants;Research Support;revascularization surgery;Role;side effect;Site;Stem Cell Mobilization;stem cells;Stress;Structure;success;Therapeutic;Therapeutic Agents;therapeutic angiogenesis;Therapeutic Effect;therapeutic effectiveness;Therapeutic Intervention;therapeutically effective;Tissue Engineering;Tissues;tool;Treatment Efficacy;United States;Vascular Diseases;Work

PROJECT_TITLE: Novel nanoparticles to stimulate therapeutic angiogenesis in peripheral arterial disease

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Regenerative Medicine;Wound Healing and Care

ORG_CITY: PULLMAN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because understanding how to transform scar tissue to functionally regenerate has the potential to impact anyone who undergoes surgery, but also individuals with clinical conditions associated with scarring. The proposed research is relevant to NIH's mission because understanding fibroblast biology and skin regeneration has the potential to improve human health and generate a new knowledge base to study cancer and diseases associated with dysfunctional fibroblasts.

PI_NAMEs: DRISKELL, RYAN  (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Ablation;Adipocytes;Adult;age effect;Aging;aging reversal;Arthritis;Attenuated;Biological Assay;Biological Models;Biology;burn therapy;Cell Differentiation process;Cells;cellular targeting;ChIP-seq;chronic wound;Cicatrix;Clinical;Clinical Treatment;Cosmetics;Data;Dermal;Dermis;Development;Diabetes Mellitus;diabetic ulcer;Disease;Elderly;Embryo;Epidermis;experimental study;Extracellular Matrix;Fibroblasts;Functional Regeneration;genetic signature;Goals;Hair;Hair follicle structure;hair regeneration;Health;Heterogeneity;Homeostasis;Human;Impaired wound healing;improved;in vivo;Individual;innovation;Keloid;Knowledge;knowledge base;Malignant Neoplasms;Marketing;Methods;migration;Mission;Molecular;Molecular Target;mouse model;Mus;Natural regeneration;Neonatal;neonatal mice;next generation sequencing;novel;novel strategies;Obesity;old mice;Operative Surgical Procedures;organ regeneration;overexpression;Pain;Papillary;Pathway interactions;Process;programs;Psoriasis;psychological trauma;Public Health;regeneration potential;regenerative;Regenerative capacity;Regulon;repaired;Research;Role;Scleroderma;single-cell RNA sequencing;Skin;Skin Aging;skin regeneration;skin wound;Skin wound healing;Source;Specific qualifier value;Technology;Testing;tissue culture;Tissues;tongue papilla;transcription factor;transgene expression;Transgenic Mice;Transgenic Model;Transgenic Organisms;United States;United States National Institutes of Health;wound;wound bed;wound healing

PROJECT_TITLE: Investigating the role of Lef1 in fibroblast lineages to induce skin regeneration and reverse aging

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: PROJECT NARRATIVE The “Training Program in Basic and Translational Pediatric Oncology Research” will create a cadre of well- trained researchers in pediatric cancer who communicate and collaborate broadly, partner with clinicians and clinical scientists, and help bring basic and translational science discoveries to the clinic to transform the care of pediatric cancer patients.

PI_NAMEs: CRIPE, TIMOTHY P (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Cancer;Genetics;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: PROJECT NARRATIVE Epithelial ovarian cancer (EOC) is the leading cause of gynecologic cancer-related deaths in the United States. EOC is a genetically heterogeneous disease, and therefore it is imperative to develop novel therapeutic strategies based on patients’ genetic makeup such as overexpression of an oncogene CARM1. This proposal will lay a critical foundation to establish the use HSP70 inhibitors in CARM1-expressing epithelial ovarian cancer and if successful it will have an immediate impact on ovarian cancer patients.

PI_NAMEs: KARAKASHEV, SERGEY  (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: 3-Dimensional;Advisory Committees;Antineoplastic Agents;Apoptosis;Arginine;ATP phosphohydrolase;Biological Assay;brca gene;cancer cell;Cancer cell line;Cancer Patient;cancer type;career;career development;Cell Culture Techniques;Cells;Cessation of life;Clinical;clinically relevant;coactivator-associated arginine methyltransferase 1;Data;Development;Disease;Down-Regulation;Epigenetic Process;Epithelial ovarian cancer;experimental study;EZH2 gene;Foundations;gain of function;Gene Expression;Genes;genetic makeup;genome-wide analysis;Goals;Growth;Heat Shock 70kD Protein Binding Protein;heat-shock proteins 40;Heat-Shock Proteins 70;In Vitro;in vivo;in vivo Model;inhibitor;Invaded;Knock-out;Knowledge;loss of function;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mentors;Methylation;Methyltransferase;migration;Modification;Molecular;mouse model;mutant;Mutation;novel strategies;novel therapeutic intervention;Oncogenes;Ovarian Serous Adenocarcinoma;overexpression;Pathway interactions;patient derived xenograft model;Patients;Pennsylvania;Postdoctoral Fellow;Pre-Clinical Model;pre-doctoral;Proliferating;protein folding;Protein-Arginine N-Methyltransferase;Proteins;Research;Research Personnel;Resources;Role;Serous;Site;Site-Directed Mutagenesis;skills;small molecule inhibitor;small molecule libraries;Specificity;synergism;targeted treatment;Testing;The Wistar Institute;Training;Training Support;tumor;Tumor Suppression;two-dimensional;United States;Universities

PROJECT_TITLE: Targeting HSP70 in CARM1-expressing epithelial ovarian cancer

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Neurosciences;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: The Ras pathway is one of the most commonly deregulated pathways in human cancer, yet there are still no effective therapies for Ras-driven tumors. In this application we will be studying two genetically distinct Ras-driven malignancies. Specifically, we aim to elucidate an important mechanism by which these Ras-driven cancers are protected from MEK inhibitors and will use this insight as a basis for developing and testing rational combination therapies.

PI_NAMEs: CICHOWSKI, KAREN M (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Ablation;Apoptotic;BIM Bcl-2-binding protein;Cell Death;Cell Death Induction;Cell Line;Cell Proliferation;Chemicals;Clinical;Clinical Trials;Collaborations;combinatorial;Combined Modality Therapy;Complex;Data;Development;Drug Combinations;effective therapy;Goals;Grant;Human;In Vitro;in vivo;in vivo Model;inhibitor;insight;Investigation;KRAS2 gene;Malignant neoplasm of pancreas;Malignant Neoplasms;MCL1 gene;Mediating;MEK inhibition;MEKs;Modeling;mutant;Mutation;Nervous System Neoplasms;NF1 gene;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Organoids;Pathway interactions;Phase I Clinical Trials;preclinical study;pro-apoptotic protein;Proteins;RAS driven cancer;RAS driven tumor;Resistance;resistance mechanism;response;Role;Signal Transduction;success;targeted agent;Testing;Therapeutic;Time;Translating;tumor;Up-Regulation

PROJECT_TITLE: Developing new therapeutic strategies for distinct Ras-driven cancers

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Genetics;Mental Health;Mental Illness;Pediatric;Prevention;Schizophrenia;Serious Mental Illness

ORG_CITY: SEATTLE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Improving our ability to predict and prevent the onset of serious mental illnesses (SMI) will require mapping the relationships between underlying pathogenic factors, early markers of SMI, and clinical progression across development. Towards this end, we will establish a new cohort of 3,000 children and early adolescents enriched for SMI risk in the Paisa population of Colombia, and analyze the relationships between clinical and neurobehavioral signs and symptoms in childhood, individualized genetic risk profiles, and longitudinal clinical outcomes. Through this work, we aim to improve SMI prediction, prior to full illness onset, and further our understanding of how psychiatric phenotypes relate to one another and underlying genetic risk factors.

PI_NAMEs: FORSYTH, JENNIFER KATHERINE (contact);PALACIO, JUAN  DAVID

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: 15 year old;Adolescent;Adult;Andean;Anxiety;Attention deficit hyperactivity disorder;autism spectrum disorder;biomarker identification;Bipolar Disorder;Characteristics;Child;Childhood;Clinical;clinical development;clinical phenotype;Cognitive;cohort;Colombia;Complex;Computerized Medical Record;Databases;Development;Diagnosis;Diagnostic;Disease;disease classification;DNA;Early Intervention;Emotional;emotional functioning;Ensure;Epidemiology;Etiology;follow-up;Future;Gene Frequency;Genetic;genetic architecture;Genetic Risk;genetic risk factor;Genetic study;genetic variant;genome-wide;Genotype;Goals;high risk population;improved;Individual;Infrastructure;Intellectual functioning disability;Interview;Knowledge;lens;Manic;Maps;Mental Depression;mental development;Mental disorders;Motor;neurobehavioral;Neurobehavioral Manifestations;Onset of illness;Outcome;Pathogenesis;Pattern;Phenotype;polygenic risk score;Population;Populations at Risk;predictive marker;prevent;Psychiatric Diagnosis;Psychiatric Hospitals;Psychiatry;psychologic;Psychopathology;Psychoses;rare variant;Risk;Sampling;Schizophrenia;schizophrenia risk;Sensory;severe mental illness;Severities;Specificity;Staging;Structure;Symptoms;Syndrome;Time;Traction;trait;Undifferentiated;United States National Institutes of Health;Variant;Virulence Factors;Work

PROJECT_TITLE: Genetic Risk for Serious Mental Illness and Development

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: DAVIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE The mitochondrial electron transport chain (ETC) is an essential metabolic pathway in humans, and its disfunction causes debilitating and fatal diseases with no current treatments. The goal of this proposal is to understand, at the atomic level, the mechanism and regulation of mitochondrial ETC complexes and supercomplexes. Defining how the enzymes function and can be regulated in diverse contexts will provide the basic science foundation for future strategies in drug development and treatment of metabolic disease.

PI_NAMEs: LETTS, JAMES ANTHONY (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: 10 year old;Address;Basic Science;Biochemical;Bioenergetics;Biological Models;Cell Culture Techniques;Complex;Cryoelectron Microscopy;Defect;Diagnosis;Disease;drug development;effective therapy;Electron Transport;Enzymes;Event;Family suidae;Foundations;Functional disorder;Future;Genetic;Goals;Heart;Heart Mitochondria;Hela Cells;Human;Individual;insight;Life;Medical;Membrane Proteins;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolism;Mitochondria;Molecular;Neurospora crassa;Organism;Oxidative Phosphorylation;Paracoccus denitrificans;particle;Patients;Pharmacotherapy;Physiological;Production;protein complex;Proteobacteria;Regulation;Research;Resolution;Respiration;respiratory;Role;stem;Structure;System;Testing;therapeutic development;Tissues;treatment strategy;Work

PROJECT_TITLE: Understanding the Mechanisms of Respiratory Supercomplexes and mitochondrial Complex I

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: PROJECT NARRATIVE The innate immune system serves as the first line of defense against pathogens, including coronaviruses. The research proposed in this application will characterize innate immune sensors and downstream pathways that are involved in the response to SARS-CoV-2 infection. These studies will inform the development of future therapeutic interventions to prevent the morbidity and mortality of COVID-19 as well as other diseases associated with inflammatory cytokine release.

PI_NAMEs: KANNEGANTI, THIRUMALA-DEVI  (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: 2019-nCoV;Applications Grants;Area;Basic Science;Biological;CASP3 gene;CASP6 gene;CASP8 gene;Cell Death;Cell Line;Cells;Clinical;Clinical Data;Communicable Diseases;Complex;Coronavirus;Coronavirus Infections;COVID-19;COVID-19 mortality;COVID-19 pandemic;COVID-19 patient;COVID-19 treatment;cytokine;cytokine release syndrome;Data Analyses;Development;Disease;Ensure;experience;Functional disorder;Future;global health;Grant;Host Defense;Human;human disease;Hyperactivity;IL18 gene;Immune;Immune signaling;Immunology;improved;in vivo;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Influenza A virus;innate immune mechanisms;innate immune pathways;Innate Immune Response;Innate Immune System;innovation;insight;interest;Interferon Type II;Interferons;Interleukin-1 beta;Lead;Mediating;microbial;Molecular;Morbidity - disease rate;mortality;Mus;Natural Immunity;Nature;novel;novel coronavirus;novel therapeutic intervention;pandemic disease;Paper;pathogen;Pathogenicity;Pathology;Pathway interactions;Peer Review;Play;post SARS-CoV-2 infection;prevent;Procedures;Production;Publications;Publishing;Receptor Signaling;Reproducibility;Research;respiratory;response;RIPK1 gene;RIPK3 gene;RNA Viruses;Role;SARS-CoV-2 infection;sensor;Severity of illness;Signal Pathway;systemic inflammatory response;targeted treatment;Therapeutic;Therapeutic Intervention;Tissues;TNF gene;Toll-like receptors;translational potential;Viral;Viral Pathogenesis;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Targeting innate immune pathways, and inflammatory cell death in cytokine-mediated diseases

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: EAST LANSING

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative Infections with drug resistant Gram-positive bacteria pose a serious threat to patients in clinical settings. A key to controlling and preventing pathogenic outbreaks is to understand how bacteria evade attack by antimicrobial compounds. In this work we will combine structural and functional analyses to understand how membrane protein complexes called “Bce modules” sense and provide resistance to antimicrobial peptides in Gram-positive bacteria.

PI_NAMEs: ORLANDO, BENJAMIN JOSEPH (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: anti-microbial peptide;Antibiotics;antimicrobial;Antimicrobial Resistance;ATP-Binding Cassette Transporters;Award;Bacteria;Biochemical;Clinical;Complex;Computing Methodologies;Cryoelectron Microscopy;Dedications;Development;Disease Outbreaks;Drug resistance;drug resistant bacteria;Environment;Genus staphylococcus;Goals;Gram-Positive Bacteria;Health;health care settings;Human;Human body;improved;in vivo;Infection;insight;Kinetics;Laboratories;Membrane;Membrane Proteins;Membrane Structure and Function;Membrane Transport Proteins;Microbial Drug Resistance;Modeling;Molecular;Molecular Conformation;Organism;pathogen;pathogenic bacteria;pathogenic microbe;Pathogenicity;Patients;prevent;Protein Analysis;protein complex;Proteins;Resistance;Resolution;Signal Transduction;Stimulus;Structure;synergism;System;targeted treatment;Vancomycin;Vancomycin resistant enterococcus;Work

PROJECT_TITLE: Structural Basis of Antimicrobial Peptide Sensing and Resistance

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: DC

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: IOWA CITY

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Program Director/Principal Investigator (Last, First, Middle): Gantz, Bruce J. PROJECT NARRATIVE – OVERVIEW, CORE A, CORE B This research has the potential to develop a better understanding how the brain processes speech amongst challenging listening situations by parsing out critical issues from all levels of the auditory system and as it relates to understanding in the real-world. We investigate the influence of factors, such as higher order cognitive processes (e.g., working memory and executive functioning), with high potential to understand speech in noise abilities among individuals with hearing loss. Understanding the effect of these abilities on communication and socialization during real-world listening and its influence on psychosocial well-being could have long-term impact on cognitive stability.

PI_NAMEs: GANTZ, BRUCE JAY (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Accent;Acoustic Nerve;Acoustics;Age;Attention;Auditory;Auditory system;Bilateral;Binaural;Brain;Characteristics;Clinical Research;Cochlear Implants;Cochlear Nerve;Cognition;Cognitive;cognitive capacity;cognitive function;cognitive process;cognitive system;cohort;Communication;Communication difficulty;Compensation;Cues;Data;deafness;demographics;Devices;Ear;Ecology;Electrodes;Environment;executive function;face mask;flexibility;Frequencies;Funding;Genetic Variation;Grant;Grouping;Hearing;Hearing Aids;hearing impairment;Human;implantation;improved;Individual;information processing;insight;Investigation;Iowa;language processing;lexical processing;Life;Managed Care;Medical;Modality;Noise;Outcome;outcome prediction;patient registry;Patients;Perception;Performance;Peripheral;Persons;Population;Predictive Factor;predictive modeling;preservation;Principal Investigator;Process;programs;psychosocial wellbeing;Quality of life;Registries;Rehabilitation therapy;Research;Research Project Grants;Residual state;Robotics;Sensorineural Hearing Loss;Short-Term Memory;Side;Signal Transduction;Social Interaction;Socialization;Speech;speech in noise;Speech Perception;standard of care;Steroids;Structure;success;Transcend;Uncertainty;Work

PROJECT_TITLE: Iowa Cochlear Implant Clinical Research Center VIII


PHR: Program Director/Principal Investigator (Last, First, Middle): Gantz, Bruce J. NARRATIVE See Overview for project narrative for the project’s relevance to public health.

PROJECT_TERMS: Brain;Clinical Research;Cochlear Implants;Doctor of Philosophy;Ensure;Grant;Human Resources;Iowa;Monitor;multidisciplinary;operation;Otolaryngology;Principal Investigator;programs;psychologic;Public Health;Research;Science;Structure

PROJECT_TITLE: Iowa Cochlear Implant Clinical Research Center Project VIII


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Natural Products;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: CHEMISTRY

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE Assembly-line polyketide synthases are multifunctional catalytic machines responsible for the biosynthesis of structurally complex and diverse natural products including many antibiotics. The objective of this research is to advance a fundamental understanding of the structure, mechanism and evolution of these enzymatic assembly lines. We also seek to test our understanding of these assembly lines by decoding a polyketide synthase commonly found in isolates of Nocardia associated with nocardiosis.

PI_NAMEs: KHOSLA, CHAITAN  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Acyl Carrier Protein;Anabolism;Antibiotics;Biological;Biological Assay;Candidate Disease Gene;candidate identification;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Cryoelectron Microscopy;Engineering;Enzymatic Biochemistry;Enzymes;Epitopes;Evolution;Experimental Models;flexibility;Gene Conversion;Genes;Genetic;genetic element;Genetic Models;genome-wide;glycosylation;Goals;Human Cell Line;In Vitro;Individual;insight;Investigation;knock-down;Knock-out;Laboratories;Logic;Macrophage;Molecular Conformation;Monoclonal Antibodies;Names;Natural Products;Nocardia;Nocardia Infections;novel;Nucleotides;Orphan;Phenotype;Play;polyketide synthase;polyketides;Reaction;reconstitution;Research;Roentgen Rays;Role;small hairpin RNA;Specificity;Streptomyces;Structure;tailored natural product;Testing

PROJECT_TITLE: Mechanisms and Evolution of Assembly-Line Polyketide Synthases


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Hearing Loss;Prevention;Rehabilitation

PROJECT_TERMS: Address;Audiology;Clinical Research;Clinical Services;Cochlear Implants;Computers;Data;data management;Data Mart;data modeling;design;Doctor of Philosophy;Evaluation;Goals;Hearing;Image Analysis;Individual;Iowa;Monitor;Outcome Measure;Patients;Performance;Population;Postoperative Period;Principal Investigator;programs;Psychophysics;Public Health;Registries;Research;Research Personnel;Research Project Grants;Residual state;Schedule;Speech Perception;timeline

PROJECT_TITLE: Iowa Cochlear Implant Clinical Research Center - VIII


ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative This proposed projectdevelops a self-sustainablepower source (SSPS) for intracardiacpacemakers using swine models. The SSPS integrates a stretchable, frequency-tuning implantable nanogenerator with a miniaturized supercapacitor and regulating electronics, which can automatically and consistently power a pacemaker by harvesting energy from heartbeats. This project will establish the technology framework necessary to move rapidly to in vivo intracardiac implantation and the testing of SSPS for powering intracardiac pacemakers.

PI_NAMEs: WANG, XUDONG  (contact)

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TITLE: Nanogenerator-Driven Self-Sustainable Power Source for Intracardiac Pacemakers

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Genetics;Hearing Loss;Neurosciences;Prevention;Rehabilitation

PHR: PROJECT 1: PROJECT NARRATIVE The proposed study is relevant to public health because it aims 1) to determine functional benefits of two techniques of reducing intracochlear trauma caused by cochlear implant surgery, and 2) to better understand the relationship between genetic variations and peripheral auditory function. Results from this study will have a broad impact on the field by 1) providing the scientific foundation for shifting the current clinical practice for cochlear implant patients by implementing Dex-eluting electrode array or robotics-assisted electrode insertion as part of standard clinical care, and 2) laying the groundwork for developing effective, evidence-based clinical practice guidelines for managing cochlear implant patients based on their genetic etiologies. This project is relevant to the mission of NIH because it seeks fundamental knowledge about the nature of electrical hearing and strives to apply this knowledge to reduce disability in patients with cochlear implants.

PI_NAMEs: HANSEN, MARLAN R (contact)

PROJECT_TERMS: Accounting;Acoustic Nerve;Acoustic Stimulation;Acoustics;Action Potentials;Address;Affect;Animal Model;Anti-Inflammatory Agents;Auditory;Auditory Perception;auditory processing;Auditory system;behavior measurement;Cadaver;Clinical;clinical care;clinical practice;Clinical Practice Guideline;Clinical Research;clinically significant;Cochlea;Cochlear implant procedure;Cochlear Implants;Cochlear Nerve;Cognition;cohort;Complex;Data;Dexamethasone;disability;electric impedance;Electric Stimulation;Electrocochleographies;Electrodes;Electrophysiology (science);Environment;evidence base;exome sequencing;Fibrosis;Foreign-Body Reaction;Foundations;functional status;Genes;Genetic;Genetic Predisposition to Disease;genetic variant;Genetic Variation;Goals;Growth;Hair Cells;Health;Hearing;hearing impairment;hearing preservation;Human;Immune response;implantation;Implanted Electrodes;improved;Inflammatory Response;Interphase;Iowa;Kinetics;Knowledge;Manuals;Measures;Mission;Modeling;Monitor;Nature;Nerve;neural;neuron loss;Neurons;neurophysiology;novel strategies;Operative Surgical Procedures;Otoscopes;Outcome;Participant;patient population;Patients;Performance;Peripheral;Phase;Physiologic Ossification;Physiologic pulse;Postoperative Period;precision medicine;preservation;Process;protective effect;Public Health;Randomized;Residual state;Robotics;Scanning;Speech;Speech Perception;Speed;spiral ganglion;Steroids;Structure;success;Surgeon;System;Techniques;temporal measurement;Time;Trauma;Tremor;United States National Institutes of Health;Variant;X-Ray Computed Tomography

PROJECT_TITLE: Project 1: Preservation of Peripheral Function and Structure


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: NARRATIVE Medulloblastomas are one of the most common pediatric brain tumors, and they have not benefited from recent dramatic advances in treating cancer by activating the immune system. Our study proposes developing a detailed molecular and cellular understanding of how these tumors interact with the immune system. Through computational modeling of these data, we will seek approaches that could alter the immune system to benefit medulloblastoma patients.

PI_NAMEs: FRAENKEL, ERNEST  (contact);MESIROV, JILL P.

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Address;Binding;Blood;Blood - brain barrier anatomy;Brain;Brain Neoplasms;causal model;CD47 gene;Cell Communication;Cell surface;Cell Surface Proteins;cell type;Cells;Childhood Brain Neoplasm;Childhood Malignant Brain Tumor;Circulation;Clinical;Clinical Data;clinically relevant;Computer Analysis;Computer Models;cytokine;Data;deep sequencing;Dendritic Cells;disease model;Environment;experimental study;Genes;genetic regulatory protein;Human;imaging modality;Immune;immune cell infiltrate;Immune Evasion;immune modulating agents;Immune system;Immunofluorescence Immunologic;Immunologic Markers;Immunologic Surveillance;Immunooncology;immunoreaction;immunoregulation;Immunosuppression;Immunotherapy;improved;innovation;insight;Intervention;Ligands;Link;Macrophage;Major Histocompatibility Complex;Malignant Neoplasms;Maps;Medulloblastoma;Methods;Microglia;Modeling;Molecular;mouse model;multi-scale modeling;Mus;mutant;Natural Killer Cells;neoplastic cell;novel;Outcome;outcome prediction;Pathway interactions;Patients;Periodicity;Peripheral;phosphoproteomics;Property;protein complex;protein expression;Proteomics;Regulation;Regulatory Pathway;Research;Sampling;Sampling Studies;Shapes;SHH gene;Signal Transduction;single-cell RNA sequencing;Site;Solid Neoplasm;Stream;Surface;Surface Antigens;Systems Biology;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapeutic candidate;therapeutic development;therapeutic evaluation;Therapeutic Intervention;therapeutic target;TNF gene;TP53 gene;transcriptomics;Translating;tumor;tumor growth;Tumor Promotion;Tumor Subtype;Tumor-associated macrophages;tumor-immune system interactions;Update;Variant;Work

PROJECT_TITLE: Identifying therapeutic pathways targeting medulloblastoma-immune cell interactions


NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Hearing Loss;Neurosciences;Rehabilitation

PHR: PROJECT 2: PROJECT NARRATIVE Project 2 investigates the auditory cognitive mechanisms that are responsible for perceiving and attending to acoustic patterns over frequency and time. We will assess cochlear implant users’ performance and cortical activities for auditory cognition tasks operating over the various timescales from words to sentences including the grouping of coherent spectro-temporal patterns, auditory working memory, endogenous attention, and how the performance and neural activities change over time. The outcome of this study will characterize auditory cognitive mechanisms in CI users that apply to speakers of any language of any ability, and with neural measures that can be realistically applied to clinical populations.

PI_NAMEs: CHOI, INYONG  (contact)

PROJECT_TERMS: Acoustics;Affect;Attention;attentional modulation;Auditory;Auditory area;Auditory system;base;behavioral study;Brain;Brain imaging;Clinical;Clinical Research;Cochlea;Cochlear Implants;Cognition;Cognitive;cognitive process;cognitive task;Complex;Cross-Sectional Studies;Crowding;Cues;Demographic Factors;Detection;Devices;Diffusion;Electroencephalography;experimental study;Frequencies;Grouping;Hearing;hearing range;implantation;improved;Iowa;Language;language processing;Left;lifestyle factors;Measures;Mind;Modeling;neural;neuroimaging;Noise;noise perception;normal hearing;Outcome;Outcome Study;Patients;Pattern;Perception;Performance;Peripheral;Population;Positron-Emission Tomography;preimplantation;Process;Rehabilitation therapy;response;Sensorineural Hearing Loss;Series;Short-Term Memory;Signal Transduction;sound;Source;Speech;speech in noise;Stream;success;successful intervention;Testing;Time;tool;Variant;Visual;Water;Work

PROJECT_TITLE: Project 2: Central Auditory Integration and Plasticity


ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

ORG_DEPT: PHARMACOLOGY

PHR: Project Narrative The proposed training program will prepare students to be leaders in the field of pharmacological sciences. Integrative Pharmacological Sciences Training Program (IPSTP) trainees will receive in-depth training in the science of drug discovery, in vivo pharmacology, and computational pharmacology. Also, trainees completing this program will make important contributions to our understanding of the causes and treatments of human illness. Students will graduate from the program prepared for a range of scientific careers in academia, industry, and government.

PI_NAMEs: DORRANCE, ANNE M. (contact);LEINNINGER, GINA MARIE

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: pharmacologic;Science;Training Programs

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: Project Narrative The proposed project is consistent with NIDCD’s focus on improving language interventions for young children with autism spectrum disorder (ASD), including those who are minimally verbal. Findings will improve our ability to offer empirically supported clinical recommendations regarding adult linguistic simplification, thereby advancing evidence-based practice and maximizing long-term outcomes in children with ASD.

PI_NAMEs: VENKER, COURTNEY E (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: 4 year old;Address;Adopted;Adult;Affect;Agreement;autistic children;Behavioral;Characteristics;Child;Child Language;Clinical;clinical application;clinical practice;Cognitive;Cues;Data;Development;Evidence based practice;Exclusion;Exposure to;Goals;Hearing;improved;Intervention;Knowledge;Language;Language Delays;Language Development;language processing;Learning;Learning Disorders;Length;Linguistics;Maps;Measures;minimally verbal;National Institute on Deafness and Other Communication Disorders;Observational Study;Outcome;Participant;Process;processing speed;Quality of life;Recommendation;Schools;Severities;skills;social relationships;Speech;Standardization;Structure;theories;Time;tool;verbal;word learning;Work

PROJECT_TITLE: How Single-Word and Telegraphic Simplification Affects Language Processing and Word Learning in Young Children with Autism Spectrum Disorder

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Hearing Loss;Neurosciences;Prevention;Rehabilitation;Social Determinants of Health

PHR: PROJECT 3: PROJECT NARRATIVE Project 3 investigates the cognitive mechanisms by which cochlear implant users process speech more efficienctly, a necessityfor real-world listening in challenging environments. It investigates a range of modifiable and predictive factors including real-world experience, language skills, listening effort, cortical integrity, and integration across ears, and it links these factors to eye-tracking measures of language processing efficiency and ecological momentary assessment of real-world outcomes. This will improve cochlear implantation criteria, suggest new standards for assessment outcomes and foster new avenues for improving post-implantation outcomes.

PI_NAMEs: MCMURRAY, BOB  (contact)

PROJECT_TERMS: Address;age related decline;Aging;Attention;Auditory;Bilateral;Binaural;Brain imaging;Categories;Clinical;Clinical Research;Cochlear implant procedure;Cochlear Implants;Cognitive;cognitive ability;cognitive process;cognitive skill;coping;Cross-Sectional Studies;Cues;Data;deafness;density;design;Devices;Dichotic Listening Tests;Dimensions;Ear;Ecological momentary assessment;Environment;Exhibits;expectation;experience;Eye Movements;falls;flexibility;Fostering;Funding;gray matter;Hearing;Hearing Aids;hearing impairment;Impaired cognition;implantation;improved;indexing;Individual Differences;Iowa;Language;language comprehension;language processing;lexical;lexical processing;Link;Longitudinal Studies;Loudness;Magnetic Resonance Imaging;Measures;Modality;Modeling;multimodality;Nature;Neuropsychological Tests;Noise;normal hearing;novel;Outcome;Outcome Assessment;outcome prediction;Pathway Analysis;Patients;Performance;Periodicals;Phonetics;Predictive Factor;preimplantation;Principal Component Analysis;Process;Psychophysics;Reading;Research;Role;Sampling;Semantics;Short-Term Memory;Side;Signal Transduction;skills;Social Environment;Social Network;sound;Speech;speech in noise;Speech Perception;speech recognition;standardize measure;Structure;System;Techniques;Testing;Time;Translating;Uncertainty;Variant;Visual;visual tracking;Work;Writing

PROJECT_TITLE: Project 3: Efficiency of Language Processing


NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hearing Loss;Neurosciences;Prevention;Rehabilitation;Social Determinants of Health

PHR: PROJECT NARRATIVE – HUMAN ECOLOGY – PROJECT 4 We seek a better understanding of the mechanisms that link changes in auditory function following cochlear implantation (CI) to listening success in challenging real-world environments and quality of life. This has implications to improve CI candidacy decisions, counselling of patients, and post-implantation rehabilitation.

PI_NAMEs: DUNN, CAMILLE C (contact)

PROJECT_TERMS: Accent;Adult;Affect;Age;Audiology;Auditory;Auditory system;Automobile Driving;Behavior;Characteristics;Clinic;Clinical;clinical care;Clinical Research;Cochlear implant procedure;Cochlear Implants;Cognition;Cognitive;cognitive ability;cognitive capacity;cognitive function;cognitive skill;Communication;comparison group;Complex;Counseling;Cues;Data;Data Collection;demographics;Ear;Ecological momentary assessment;Ecology;Elderly;Environment;Environmental Risk Factor;experience;Fatigue;Frequencies;Funding;Geographic Locations;Geography;Goals;Hearing;Hearing Aids;hearing impairment;Human;Impairment;implantation;improved;In Situ;Individual;Investigation;Iowa;Laboratories;Life;Link;Literature;Measures;Mediator;Medical;Memory;microphone;mobile computing;Neuropsychology;Noise;Occupational Status;Outcome;Pathway Analysis;Patient Self-Report;Patients;Perception;Performance;Peripheral;Play;Predictive Factor;Process;Quality of life;Race;Recording of previous events;Rehabilitation therapy;remediation;Reporting;Role;Scientist;Shapes;social engagement;Social Environment;Social Functioning;social integration;Social Interaction;Social isolation;Social Network;Social support;Socioeconomic Status;sound;Specificity;Speech;Speech Perception;speech recognition;Stress;success;Surveys;Time;traditional care;trend;Visual;Work

PROJECT_TITLE: Project 4: Human Ecology (Quality of Life)


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homelessness;Infectious Diseases;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Economic vulnerability and racial disparities contribute to African-American young adults being disproportionately infected by HIV. The proposed intervention applies a peer-driven microenterprise model adapted for underserved U.S. communities and integrating text messages informed by behavioral economics to test the efficacy and mediating and differential effects on the reduction of condomless sex and increase in uptake of pre-exposure prophylaxis in high-risk, economically-vulnerable African-American young adults. Microenterprise reduces HIV risk through increased economic stability via jobs and employable income- generating skills that is hypothesized, in turn, to decrease financial distress associated with high-risk behaviors, while increasing resources to access HIV services.

PI_NAMEs: JENNINGS MAYO-WILSON, LARISSA  (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;African American;African American population;age group;aged;AIDS prevention;Appointment;Behavior;Behavioral;behavioral economics;Biometry;Businesses;Clinic;Communities;compliance behavior;condoms;Control Groups;cost;Data;design;Economics;efficacy evaluation;efficacy testing;empowerment;Epidemiology;evidence base;experience;experimental group;Financial Hardship;financial literacy;Gender;Generations;Grant;health economics;health empowerment;Heterogeneity;high risk;high risk behavior;HIV;HIV diagnosis;HIV Infections;HIV risk;HIV-1;Homelessness;Human immunodeficiency virus test;improved;Incidence;Income;Individual;insight;International;Intervention;intervention effect;low income country;marginalized population;Mediating;Mediation;medication compliance;men;Mentors;Methods;mHealth;Modeling;Motivation;Movement;Occupations;Outcome;Outcome Measure;Participant;participant interview;peer;peer support;Perception;Pharmaceutical Preparations;Population;post intervention;pre-exposure prophylaxis;Prevalence;Prevention;Prevention education;Prevention strategy;Preventive;primary outcome;Publishing;Qualitative Methods;racial disparity;Randomized;randomized, clinical trials;recruit;Resources;Respondent;Rewards;Risk;Risk Behaviors;Risk Reduction;Sampling;Science;Self Efficacy;Services;Sex Behavior;Sexual Health;sexual risk taking;Shapes;skills;Statistical Methods;Text Messaging;Training;Translating;treatment as usual;Treatment Efficacy;Unemployment;Unsafe Sex;uptake;urban setting;Woman;young adult;Youth

PROJECT_TITLE: Microenterprise and Behavioral Economics Intervention for Sexual and Biomedical HIV Prevention in Vulnerable U.S. Young Adults

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health

PHR: PROJECT NARRATIVE ADHD is a common and debilitating disorder that contributes to increased chance of deleterious risky behaviors that emerge or exacerbate in adolescence, leading to long-term negative outcomes such as addiction or incarceration. This grant proposes a comprehensive, longitudinal, multilevel (neural, behavioral, clinical) and multimodal (functional MRI, diffusion MRI) study in youth with ADHD across the transition to adolescence. By incorporating innovative brain network analytic tools and sophisticated longitudinal modeling techniques, this proposal will characterize developmental trajectories and identify childhood features that contribute to increased risk for negative outcomes in adolescence, leading to biomarker development for earlier detection of risk and more targeted treatment models for ADHD.

PI_NAMEs: COHEN, JESSICA R (contact)

PROGRAM_OFFICER_NAME: PACHECO, JENNIFER LYNN

PROJECT_TERMS: Academic achievement;addiction;Address;Adolescence;Adolescent;Adolescent Risk Behavior;adverse outcome;Affect;analytical method;analytical tool;Attention deficit hyperactivity disorder;Attitude;Behavior;Behavior assessment;Behavioral;behavioral impairment;Behavioral Symptoms;Biological Markers;biomarker development;Brain;Brain region;Characteristics;Child;Childhood;Clinical;Clinical assessments;cognitive control;cognitive system;cost;criminal behavior;Data;Decision Making;Development;developmental disease;Diagnosis;Diffusion Magnetic Resonance Imaging;Disease;Disparate;early detection biomarkers;Early Diagnosis;Early identification;Early Intervention;Education;Equation;Etiology;Family;Functional Magnetic Resonance Imaging;Future;Goals;Grant;graph theory;Health Care Costs;Healthcare;Hyperactivity;Imprisonment;Impulsivity;inattention;Individual;Influentials;innovation;Investigation;Justice;Knowledge;Link;Literature;longitudinal design;Longitudinal Studies;Magnetic Resonance Imaging;Modeling;Motivation;multimodality;neural;neural model;Neural Pathways;Neurobiology;novel;Outcome;Participant;Pathway interactions;Performance;preadolescence;predict clinical outcome;Predictive Value;Prevention;Process;programs;Public Health;Regression Analysis;Research;Research Domain Criteria;Rest;Rewards;Risk;Risk Behaviors;Risk Factors;Risk Taking;Savings;Seminal;Severities;Societies;Strategic Planning;Substance abuse problem;substance use;symptomatology;Symptoms;System;targeted treatment;Task Performances;Techniques;Time;United States National Institutes of Health;Work;Youth

PROJECT_TITLE: Longitudinal Investigation of the Neurobiological Underpinnings of Risk Behavior in ADHD throughout the Adolescent Transition: The Key Role of Cognitive Control and Motivation Network Development


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The p53 tumor suppressor pathway is a central mechanism that prevents cancer development in mammals. In this proposal, we investigate a set of novel genes, called cis-regulatory long noncoding RNAs, which we believe to be mediators of p53 function. Using a series of rigorous genetic tools, elegant functional assays, and state-of-the-art molecular and biochemical approaches, our goal is to perform comprehensive characterization of cis-regulatory long noncoding RNAs and their roles in cancer processes.

PI_NAMEs: DIMITROVA, NADYA M (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Address;Affect;Architecture;Biochemical;Biological;biological adaptation to stress;Biological Assay;c-myc Genes;Cancer Biology;Cell Cycle Checkpoint;Chromatin;Chromosome Mapping;Complex;CRISPR/Cas technology;Data;Development;Disease;Dissection;Dissociation;DNA;Dosage Compensation (Genetics);Elements;Enhancers;Epigenetic Process;Event;experimental study;Exposure to;GADD45G;gene editing technology;Gene Expression;Genes;Genetic;genetic approach;Genetic Transcription;Genotoxic Stress;Goals;Growth;Impairment;In Vitro;in vivo;innovation;Kinetics;Knowledge;Malignant neoplasm of lung;Malignant Neoplasms;Mammals;Mediating;Mediator;Modeling;Molecular;mouse model;MYC gene;novel;Oncogenes;Oncogenic;Output;Pathway interactions;Physiological;Physiology;Play;prevent;Process;Protein Isoforms;Publishing;Regulation;Regulatory Element;Repression;response;Role;Series;Site;stem;Stress;Testing;Therapeutic;tool;TP53 gene;Transcript;Transcription Coactivator;Transcriptional Regulation;Transformed Cell Line;Translating;tumor;Tumor Promotion;Tumor Suppression;Tumor Suppressor Proteins;tumorigenesis;Untranslated RNA;Work

PROJECT_TITLE: Roles and mechanisms of cis-regulatory IncRNAs in the p53 tumor suppressor pathway


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_DEPT: GENETICS

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE We are using the metazoan model organism C. elegans to explore how non-coding RNA sculpts gene expression programs, drives heritable epigenetic states, and directs antiviral and transposon defense. We rely heavily on forward genetic screens, which pragmatically cannot be done in most other systems, to help us understand these biological processes, about which little is known. We hope and expect that the work we do in C. elegans will provide a framework upon which others can build to develop novel treatments for disease in people.

PI_NAMEs: KENNEDY, SCOTT G (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Address;Animals;Biological Process;Caenorhabditis elegans;Chromatin;Development;Disease;DNA Transposable Elements;Ensure;Epigenetic Process;Etiology;Eukaryota;Gene Expression;Gene Expression Regulation;Generations;Genetic Screening;Genome;Germ Lines;Goals;Heritability;Heterochromatin;human disease;imprint;Insecta;insight;Link;Mammals;Mediating;Membrane;model organism;Modification;novel;Nuclear;Nucleic Acids;Organelles;Paramecium;Parasites;Pathway interactions;Persons;Plants;programs;Proteins;Regulation;Reproduction;Research;RNA;RNA Interference Pathway;Small Interfering RNA;System;theories;Totipotency;transgenerational epigenetic inheritance;transmission process;Untranslated RNA;vector;Viral;Work;X Inactivation;Yeasts

PROJECT_TITLE: Non-Coding RNAs in Gene Regulation, Genome Defense, and Epigenetic Inheritance

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ORG_CITY: LEXINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE  Brain metabolism, central nervous system (CNS) metabolism, and neuronal excitability are interdependent, and dysregulation of CNS metabolism is implicated in numerous neurological disorders, including Alzheimer’s Disease, epilepsy, Parkinson’s disease, and brain injury, but the mechanistic connections between CNS metabolism and disease are poorly understood. The unique, multidisciplinary Center of Biomedical Research Excellence (COBRE) on CNS Metabolism (CNS-Met) proposed here is a strategically designed, sustainable framework that promotes leading-edge research focused on the role of metabolic mediators of brain function and disease, with an emphasis on encouraging research excellence from Junior Research Project Leaders.

PI_NAMEs: SULLIVAN, PATRICK G (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Acceleration;Accounting;Alzheimer's Disease;Area;Behavior;Biochemical;Bioenergetics;Bioinformatics;Biology;biomarker discovery;Biometry;Brain;Brain Injuries;brain metabolism;Cardiovascular system;Centers of Research Excellence;Central Nervous System;Chronic;Clinical;Cognition;cohort;Collaborations;collaborative environment;college;Complex;Core Facility;Data Science;data science resource;Dedications;Defect;defined contribution;design;Development;Diabetes Mellitus;Disease;Ensure;Epilepsy;Equipment;Extramural Activities;Faculty;Fostering;Funding;Future;Glucose;glucose metabolism;Goals;Grant;Homeostasis;imaging capabilities;Infrastructure;insight;Institution;instrumentation;interest;investigator training;Investments;Kentucky;Life;Link;Malignant Neoplasms;Mediator;Medicine;Memory;Mentors;Metabolic;Metabolic dysfunction;Metabolism;metabolome;metabolomics;Methodology;mitochondrial metabolism;multidisciplinary;Nervous System Disorder;Nervous System Physiology;neuroinflammation;Neurologic Dysfunctions;neuronal excitability;Neurons;neuropathology;neurophysiology;Neurosciences;Neurosciences Research;neurotransmission;neurotransmitter biosynthesis;novel;Obesity;Outcome;Oxidation-Reduction;Parkinson Disease;Phase;Pilot Projects;Positioning Attribute;Process;programs;protein TDP-43;recruit;Research;Research Personnel;Research Project Grants;Resources;Rest;Role;Scientist;Severity of illness;skills;Structure;success;sustainability framework;Synapses;synergism;System;systems research;Techniques;Therapeutic;Training;translational impact;Translations;Traumatic Brain Injury;United States National Institutes of Health;Universities

PROJECT_TITLE: Center of Biomedical Research Excellence in CNS Metabolism


NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

PROJECT_TERMS: Advisory Committees;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Biology;Biomedical Research;Brain;Brain Injuries;brain metabolism;Cardiovascular Diseases;Cardiovascular system;career;career development;Centers of Research Excellence;Central Nervous System;Collaborations;collaborative environment;college;Committee Members;Communication;Core Facility;Data Science;Dedications;defined contribution;Diabetes Mellitus;Disease;Ensure;Epilepsy;Evaluation;experience;Faculty;faculty mentor;Fostering;Funding;Glucose;Goals;Homeostasis;Human Resources;Infrastructure;infrastructure development;innovation;instrumentation;Interdisciplinary Study;interest;Investments;Kentucky;knowledge translation;Laboratories;Leadership;Life;Malignant Neoplasms;Medicine;meetings;Mentors;Metabolism;metabolomics;metabolomics resource;mitochondrial metabolism;multidisciplinary;National Institute of General Medical Sciences;Nervous System Disorder;neural;neuroinflammation;Neurons;neuropathology;Neurosciences;Neurosciences Research;neurotransmission;next generation;novel;Obesity;Occupational activity of managing finances;operation;Parkinson Disease;Physiology;Pilot Projects;Process;programs;recruit;Regulation;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Training;Resources;Role;Schedule;Scientist;senior faculty;Senior Scientist;Services;skills;Specific qualifier value;spinal cord and brain injury;stable isotope;Stroke;Structure;Synapses;synergism;System;Techniques;Training Programs;Traumatic brain injury related dementia;Traumatic injury;tumor metabolism;United States National Institutes of Health;Universities

PROJECT_TITLE: CNS-Met Administrative Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Traumatic Head and Spine Injury

PROJECT_TERMS: Address;Alzheimer's Disease;Area;Behavior;Biochemical;Biochemical Pathway;Bioenergetics;Biological;Biological Sciences;biomarker discovery;Biomass;Biometry;Brain;brain metabolism;career development;Cells;Centers of Research Excellence;Central Nervous System;central nervous system injury;Cerebrum;clinical translation;Cognition;cohort;Communication;computerized data processing;Consult;Consultations;Data;data acquisition;Data Analyses;data reduction;Defect;defined contribution;design;Diagnosis;Disease;disease prognosis;Ensure;Epilepsy;Experimental Designs;experimental study;Fostering;Foundations;Freezing;Future;Generations;Genus Hippocampus;Glucose;glucose metabolism;Goals;Grant;Homeostasis;Human Resources;improved;Individual;Infrastructure;instrument;instrumentation;interest;Kentucky;Leadership;Libraries;mass analyzer;Mass Fragmentography;Mass Spectrum Analysis;Measures;member;Memory;Mentorship;Metabolic;Metabolic Diseases;Metabolism;metabolome;metabolomics;Methods;Mitochondria;mitochondrial metabolism;Modernization;Molecular;monomer;multidisciplinary;Nervous System Disorder;neuroinflammation;Neurons;neurotransmitter biosynthesis;Ontology;operation;Output;Oxidation-Reduction;Parkinson Disease;Pathway interactions;Patients;personalized medicine;Pharmaceutical Preparations;Phase;Pilot Projects;Preparation;Process;prospective;Research;Research Personnel;Research Project Grants;response;Running;sample fixation;Sampling;Scientist;skills;skills training;Spinal cord injury;Statistical Data Interpretation;success;Sustainable Development;Synapses;Talents;Techniques;Technology;Testing;Time;Tissue Microarray;Tissue Sample;Tissues;Training;Training and Education;Traumatic Brain Injury;Treatment outcome;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: CNS-Met Metabolomics Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

PI_NAMEs: YAMASAKI, TRITIA  (contact)

PROJECT_TERMS: Affect;Age;alpha synuclein;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Amino Acids;Amyloid beta-Protein;Bile Acids;Biological Markers;biomarker evaluation;Blood;brain tissue;candidate marker;Centers of Research Excellence;Cerebrospinal Fluid;Clinic;Clinical;clinical diagnosis;clinical subtypes;Clinical Trials Design;Cognition;Cognitive;cognitive change;cognitive impairment in Parkinson's;cognitive testing;Communities;Consent;cost;Data;Deep Brain Stimulation;demented;Dementia;Deposition;Development;Diagnosis;Disease;disorder control;Enrollment;Equipment;Essential Tremor;falls;Fatty Acids;Future;Gas Chromatography;Genetic;Goals;Health Care Costs;Healthcare;Impaired cognition;Individual;Kentucky;lipidomics;Lipids;liquid chromatography mass spectroscopy;Mass Chromatography;Mass Spectrum Analysis;Measurement;Measures;Metabolic dysfunction;Metabolism;metabolome;metabolomics;Methods;mild cognitive impairment;Mitochondria;Morbidity - disease rate;mortality;motor impairment;Movement Disorders;multicatalytic endopeptidase complex;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;neuropathology;non-demented;novel;Operative Surgical Procedures;Parkinson Disease;Parkinson's Dementia;Participant;Pathologic;Pathology;Pathway interactions;Patients;Persons;Plasma;Population;Preventive therapy;Process;Prognosis;prognostication;Proteins;Protocols documentation;Publishing;Research;Resources;sample collection;Sampling;Sphingolipids;Stress;tau Proteins;Testing;Therapeutic Intervention;therapeutic target;Time;Tissues;treatment trial;Tremor;Universities;Unsaturated Fatty Acids;Work

PROJECT_TITLE: Identifying Metabolomic Markers in Conversion to Cognitive Impairment in Parkinson's Disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cerebrovascular;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

PI_NAMEs: HUBBARD, WILLIAM BRAD (contact)

PROJECT_TERMS: Acute;acute symptom;Alzheimer's Disease;axonal degeneration;Bioenergetics;Biological Assay;Blood - brain barrier anatomy;Blood capillaries;Blood Vessels;Brain;brain tissue;Carbon;cell type;cellular targeting;Centers of Research Excellence;cerebral capillary;Cerebrovascular Circulation;Chronic;Citric Acid Cycle;Classification;cohort;Data;dementia risk;design;Disease;Dose;Drug Targeting;Endothelial Cells;Enhancers;Euthanasia;Female;Fostering;Foundations;Freezing;Functional disorder;functional outcomes;Future;Genus Hippocampus;Glutamates;Glycolysis;Hippocampus;Impaired cognition;Impairment;Injury;innovation;insight;Label;Long-Term Effects;Magnetic Resonance Imaging;Magnetism;male;Mass Fragmentography;Metabolic;Metabolic dysfunction;Metabolism;metabolomics;mild traumatic brain injury;Mitochondria;mitochondrial dysfunction;Modeling;neural;neurobehavioral;Neuroglia;neuron loss;Neurons;neurovascular unit;Nicotinamide Mononucleotide;novel;Outcome;oxidative damage;Oxidative Stress;Pathologic;Pathology;Patients;Pericytes;primary outcome;Procedures;protective efficacy;Proteins;Public Health;Pyruvate;Rattus;repaired;Reporting;Resources;response;restoration;small molecule;Sprague-Dawley Rats;Synapses;Techniques;Therapeutic;therapeutic development;Therapeutic Effect;therapeutic target;Tight Junctions;Traumatic Brain Injury

PROJECT_TITLE: Investigating and treating metabolic deficits in the neurovascular unit following mild traumatic brain injury


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: SELENICA, MAJ-LINDA B (contact)

PROJECT_TERMS: Adult;Affect;age related;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Amyloid;Animal Model;Astrocytes;behavioral phenotyping;Biochemical;Bioenergetics;Biological;Biological Assay;Biology;blood glucose regulation;Brain;Brain Diseases;brain dysfunction;brain metabolism;Brain region;Cells;Centers of Research Excellence;Clinical;clinical diagnosis;Clinical Trials;Coculture Techniques;cognitive performance;comorbidity;Consensus;Coupling;Data;Defect;Dementia;deoxyhypusine monooxygenase;deoxyhypusine synthase;diabetic;diabetic patient;Disease;DNA-Binding Proteins;eIF-5A;Elderly;Elongation Factor;Encephalopathies;Enzymes;Equilibrium;Failure;Functional disorder;Genes;Genetic;Genus Hippocampus;Glucose;glucose metabolism;glucose uptake;Goals;Healthcare;Hemostatic function;Homeostasis;hypusine;Imaging Techniques;Impaired cognition;Impairment;Knowledge;limbic-predominant age-related TDP-43 encephalopathy;Link;Lysine;Mass Fragmentography;Measures;Metabolic;Metabolic dysfunction;Metabolism;metabolomics;Mitochondria;mitochondrial dysfunction;Modeling;mouse model;Mus;nano-string;Nerve Degeneration;Neurodegenerative Disorders;Neurologic;Neurons;Neuropathogenesis;neuropathology;novel;novel therapeutics;Oxidative Stress;Pathologic;Pathology;Pathway interactions;Patient-Focused Outcomes;Patients;Peripheral;pharmacologic;Phenotype;Prosencephalon;protein TDP-43;Proteins;response;Rodent;Role;Severities;Structure;Synaptic plasticity;System;tau Proteins;Technology;therapeutic biomarker;Therapeutic Effect;therapeutic target;transcriptomics;Transgenic Mice;Virulence Factors;Work

PROJECT_TITLE: Sustained eIF5A hypusination at the core of brain metabolic dysfunction in TDP-43 proteinopathies


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Natural Products

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative. The proposed research focuses on exploring the function and structure of bacterial type I polyketide synthases for structural diversification to produce new macrolide antibiotics. We will also explore microbial indole alkaloid biosynthetic systems for discovery of new biocatalysts and development of new approaches to diversify these bioactive substances.

PI_NAMEs: SHERMAN, DAVID H (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Achievement;Ally;Antibiotic Resistance;Antibiotics;Area;Bacteria;Catalytic Domain;Complex;coping;Development;Diels Alder reaction;Enzymes;flexibility;Gatekeeping;glycosylation;human pathogen;Hydroxylation;Indole Alkaloids;Macrolides;Methods;microbial;Molecular Machines;Natural Products;next generation;novel strategies;Pathway interactions;Pharmacologic Substance;polyketide synthase;polyketides;Process;Productivity;programs;Publications;Reaction;Reporting;Research;Structure;System;Testing;Therapeutic Agents;Type I Polyketide Synthase;Work

PROJECT_TITLE: Discovery and Characterization of Natural Product Systems


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PUBLIC HEALTH RELEVANCE/NARRATIVE A major challenge in identifying genetic variants contributing risk to complex disease is distinguishing genetic variants that disrupt biological function from those that do not. Approaches to distinguish these types of variants routinely take advantage of evolutionary information, either to prioritize variants that have been subjected to natural selection or to calibrate models of background genetic variation in the genome. This project is relevant to public health because it will greatly increase our knowledge of different types of deleterious mutations and, by doing so, will increase the utility of evolutionary information for identifying biologically relevant and pathogenic variants.

PI_NAMEs: LOHMUELLER, KIRK  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;Biological;Biological Process;Calibration;Code;Complex;Copy Number Polymorphism;Data;Disease;Evolution;fitness;functional genomics;Funding;Genetic Models;Genetic Polymorphism;Genetic Risk;genetic variant;Genetic Variation;Genome;genomic data;Genomics;Human;Individual;Knowledge;Laboratories;Learning;life span;Methods;Modeling;Mutation;Natural Selections;Nucleotides;Paint;Pathogenicity;Population;Population Genetics;Population Sizes;Process;Public Health;public health relevance;Research;Risk;risk prediction;Role;Short Tandem Repeat;simulation;Testing;Time;tool;trait;Untranslated RNA;Variant;Work;Yeasts

PROJECT_TITLE: Population genomics of the selective effects of new mutations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE A functional cure of HIV-1, or the establishment of antiretroviral therapy (ART)-free remission, require novel approaches to prevent or delay rebound viremia following ART cessation. A critical barrier to developing such strategies is the lack of understanding of the viral and host effector mechanisms that control HIV-1 reactivation in vivo. We recently discovered that viruses that rebound from latency following treatment interruption display the highest levels of IFN-I resistance observed at any time during the infection course. Here, we will characterize the viral factors that contribute to this phenotype and dissect key host defense mechanisms that place pressure on the rebounding virus pool. Harnessing these defenses may translate into more effective HIV/AIDS cure strategies.

PI_NAMEs: BAR, KATHARINE JUNE (contact);HAHN, BEATRICE H

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Acute;Address;Aftercare;Animal Model;antiretroviral therapy;Binding;Biodiversity;Biological;Biology;Blood;Blood Tests;Brain;CD4 Positive T Lymphocytes;Cells;Chronic;Clinical;clinically relevant;cohort;CRISPR screen;cytokine;Data;design;Disease remission;emerging virus;Frequencies;Genes;Goals;HIV-1;HIV/AIDS;Host Defense Mechanism;Human;Immune;Immune response;improved;in vivo;Individual;Infection;insight;Integration Host Factors;Interferons;Interruption;Kinetics;knockout gene;Knowledge;Lymph;lymphatic duct;Lymphoid Tissue;Macaca mulatta;Macrophage;male;Maps;Methods;Microglia;Minority;Molecular Cloning;Myeloid Cells;novel strategies;Participant;Pathway interactions;Phenotype;Plasma;pressure;prevent;Property;Proviruses;reactivation from latency;Recrudescences;recruit;Research;Resistance;response;Sampling;simian human immunodeficiency virus;Site;Source;Testing;Thoracic Duct;Time;Tissues;Translating;Tropism;Variant;Viral;Viral Genes;viral rebound;Viral reservoir;Viremia;Virus;Woman

PROJECT_TITLE: Characterizing the viral and host effector mechanisms that govern HIV-1 rebound

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Hematology;Infectious Diseases;Sepsis

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: NARRATIVE This project will study how antibiotic-resistant bacteria evolve in vivo during gastrointestinal tract colonization and bloodstream infection in hospitalized patients. This study will generate new insights into how antibiotic- resistant bacteria cause disease, uncover new targets for therapeutic development, and inform efforts to improve the treatment and prevention of antibiotic-resistant infections in hospitalized patients.

PI_NAMEs: VAN TYNE, DARIA N (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Animals;Antibiotic Resistance;antibiotic resistant infections;antibiotic tolerance;Antibiotics;Antigens;Bacteremia;Bacterial Antibiotic Resistance;Bacterial Genes;bacterial resistance;Blood;Blood Circulation;candidate identification;Cell surface;Cell Wall;Clinical Research;combat;comparative genomics;Death Rate;Disease;DNA-Directed RNA Polymerase;Enterococcus;Enterococcus faecium;Environment;ESKAPE pathogens;experience;Face;Foundations;Gastrointestinal tract structure;Genes;Genetic;genetic analysis;Genetic Transcription;genome sequencing;genome-wide;Growth;gut colonization;Healthcare Systems;Hospitalization;Host Defense;Human;Immune;Immunocompromised Host;improved;in vivo;Individual;Infection;Infectious Diseases Research;insight;Intervention;Mediating;Medical center;Methyltransferase;Microbial Biofilms;Molecular Probes;mortality;mouse model;Muramidase;Mutation;neutrophil;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Nutrient;Oral;pathogen;Pathogenesis;Pathway interactions;Patients;Polysaccharides;Population;Population Genetics;Population Study;pressure;Prevention;Recurrence;recurrent infection;Resistance;response;Ribosomal Proteins;Ribosomes;Route;Sampling;Sepsis;Site;Specimen;therapeutic development;Time;Translations;transmission process;Universities;Vancomycin Resistance;Vancomycin resistant enterococcus;Vertebrates;whole genome;Work

PROJECT_TITLE: Adaptation of vancomycin-resistant enterococci during bloodstream infection

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: Acute kidney injury (AKI) occurs in 1-7% of hospitalizations and up to 25% of intensive care unit (ICU) admissions. Mortality rates in AKI patients, especially in ICUs, can be as high as 50-70%. AKI is also a significant contributor to the progression of chronic kidney disease. Given that in FY17 there were 683,185 acute admissions to VA Hospitals, AKI affected up to 47,823 Veterans. There were also 38,991 ICU admissions to VA Hospitals in FY17, so AKI affected up to 9,748 Veterans. As a kidney doctor at the VA, and in the South Carolina Army National Guard, I frequently see patients with AKI, and it is difficult to tell them there are no approved treatments other than supportive care. One of the most common forms of AKI is acute tubular necrosis (ATN). We linked an organelle called the primary cilium to ATN, and showed that the exocyst complex and cilia are necessary for tubule formation in cell culture. Here, we will determine how the exocyst protects against injury and enhances repair in mice, and test possible treatments for AKI.

PI_NAMEs: LIPSCHUTZ, JOSHUA H (contact)

PROJECT_TERMS: 3-Dimensional;Acute;Acute Kidney Tubular Necrosis;Acute Renal Failure with Renal Papillary Necrosis;Admission activity;Affect;Alanine;Area;Autosomal Dominant Polycystic Kidney;Cell Culture Techniques;Cell Death;cell injury;Cell Line;Cell Physiology;Cell Polarity;Cell Survival;Cells;Chronic Kidney Failure;Cilia;ciliopathy;cilium biogenesis;Circulation;Collagen;Complex;Critical Pathways;Data;Death Rate;Dependovirus;Development;Dialysis procedure;Docking;Drug Design;efficacy evaluation;EGF gene;Epidermal Growth Factor Receptor;ERBB2 gene;experimental study;Gel;Gene Delivery;Goals;Homeostasis;Hospitalization;Hospitals;Human;Human Cloning;in vivo;Injury;injury recovery;insight;Intensive Care Units;Ischemia;ischemic injury;Kidney;kidney cell;knock-down;Knock-out;Knowledge;Ligands;Link;MAPK1 gene;Mediating;Mediator;Medical;Membrane Proteins;Messenger RNA;Metabolism;Mitochondria;mitochondrial dysfunction;Mitogen-Activated Protein Kinase Inhibitor;Mitogen-Activated Protein Kinases;Monomeric GTP-Binding Proteins;Morbidity - disease rate;mortality;Mus;mutant;Mutant Strains Mice;Mutate;Mutation;novel;novel strategies;Organelles;overexpression;oxidative damage;Pathogenesis;Pathway interactions;Patients;prevent;Process;Proliferating;Proline;protective effect;protein transport;Proteins;receptor;receptor sensitivity;Recovery;Recovery of Function;Renal tubule structure;repaired;Reperfusion Injury;Reperfusion Therapy;Research;Sagittaria;Secretory Vesicles;Site;small molecule inhibitor;South Carolina;Speed;Supportive care;Technology;Testing;therapeutic target;trafficking;transduction efficiency;Tubular formation;vector;Veterans;Viral;Zebrafish

PROJECT_TITLE: The Exocyst in Ciliogenesis and Acute Kidney Injury


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Genetics;Orphan Drug;Pediatric;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

PHR: This project involves using engineered human blood vessels created with induced pluripotent stem cells as a model for disease processes and development of new therapies. Such an approach can be extremely useful for rare diseases for which developing new therapies is extremely challenging and the number of patients is insufficient for clinical trials. Specifically, we will attempt to cure a rare genetic disease using a novel gene editing approach.

PI_NAMEs: TRUSKEY, GEORGE A (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: 20 year old;Adenosine;Adenovirus Vector;age acceleration;Alternative Splicing;Apoptosis;Architecture;Arterial Fatty Streak;Arteries;arteriole;autosome;Award;base editing;base editor;Biological Assay;Biomechanics;Blood Vessels;calcification;Cause of Death;CCI-779;cell growth;Cell Nucleus;Cell Physiology;Cells;cellular engineering;Cellularity;Child;Chromatin Structure;Clinical Trials;Collaborations;Development;Disease;disease model;disease phenotype;DNA;DNA Sequence Alteration;dosage;effectiveness testing;Endothelial Cells;Enrollment;Epigenetic Process;Exhibits;Exons;Exposure to;Farnesyl Transferase Inhibitor;FDA approved;Fibroblasts;Fibrosis;First Independent Research Support and Transition Awards;functional improvement;functional restoration;Gene Expression;gene-editing approach;Genes;Genetic Diseases;genome editing;Guide RNA;histone methylation;Human;Human Engineering;human tissue;improved;In Vitro;in vivo;Individual;induced pluripotent stem cell;Inflammation;Inflammatory;Lentivirus;Lipids;Lonafarnib;Measures;Medial;Mediating;Mitochondria;Mitosis;Modeling;mouse model;Mus;Muscle function;Mutation;Myocardial Infarction;NOS3 gene;novel;novel therapeutics;Nuclear;Oxidative Stress;Pathologic;Pathology;Patients;Penetration;Perfusion;Periodicity;Point Mutation;Pre-Clinical Model;prevent;Process;Progeria;Proliferating;Protein Farnesylation;Rare Diseases;rare genetic disorder;Recovery;response;RNA;RNA Splicing;SDZ RAD;shear stress;single-cell RNA sequencing;Site;Smooth Muscle Myocytes;Stimulus;Stretching;Stroke;Structure;Syndrome;System;Testing;Therapeutic;Tissue Engineering;tool;transcriptome sequencing;Translations;Variant;Vascular calcification;Vascular Smooth Muscle;Vasodilation;Virus

PROJECT_TITLE: In Vitro Human Tissue-Engineered Blood Vessel Disease Model of Progeria

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Prevention

ORG_CITY: ATLANTA

ORG_NAME: MOREHOUSE SCHOOL OF MEDICINE

ORG_STATE: GA

PHR: PROJECT NARRATIVE Shift workers represent nearly 30 % of the US workforce, and this occupational hazard conveys increased risk for multiple pathologies liked to disrupted inflammation. Since minority groups are more likely to engage in shift work, quality research initiatives that seek to understand the mechanistic links between shift work exposure and disease may significantly impact both health equity and overall public health. Understanding these mechanisms is of paramount importance because it could lead to the identification of screening targets and clinical interventions that can help mitigate shift-work disease.

PI_NAMEs: CASTANON-CERVANTES, OSCAR  (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Anti-Inflammatory Agents;Award;Behavioral;Cardiovascular Diseases;career;Characteristics;Chronic;circadian;Circadian Dysregulation;Clinical;Complex;Data;defined contribution;Development;Diabetes Mellitus;diabetes risk;diagnostic tool;Diet;Disease;disorder risk;Endotoxins;Energy Metabolism;Environment;Environmental Risk Factor;Event;experience;Exposure to;Goals;Health;health equity;Hormones;Immune response;improved;In Vitro;Individual;Inflammation;Inflammatory;Inflammatory Response;insight;Intervention;Investigation;Light;Link;Lipopolysaccharides;Malignant Neoplasms;Measures;Mediator;Melatonin;Minority Groups;Monitor;monocyte;novel;Occupational;Occupational Exposure;occupational hazard;Pathology;Pathway interactions;Periodicity;Physical activity;Physiological;Pilot Projects;Plasma;pre-clinical research;predicting response;Predisposition;Preventive;Prospective Studies;Public Health;Research;response;Risk;Risk Assessment;Risk Factors;Sampling;screening;Screening procedure;Severities;shift work;Signal Transduction;Sleep;Sleep Deprivation;Stress;stroke risk;systemic inflammatory response;Testing;Time;tool;translational study;Work;Workplace

PROJECT_TITLE: Assessment of Inflammatory Responses and Novel Systemic Signals as Potential Screening Targets of Shift-Work Related Disruption.


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Neurosciences;Stroke;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Survivors of heart attack or stroke-induced brain injury suffer from many log-term physical, cognitive, psychological, and emotional impairments. By focusing specifically on understanding injury mechanisms that leads to mitochondrial and ultimately cellular bioenergetics failure, the research in this grant will promote the development of treatments with the ability to improve the long-term clinical outcome for stroke victims.

PI_NAMEs: KRISTIAN, TIBOR  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acute Brain Injuries;Affect;aged;aging population;Animal Model;animal old age;Animals;Balan;Bioenergetics;Brain;brain cell;Brain Injuries;Catabolism;Cell Death;Cell Death Process;cell type;Cerebral Ischemia;Clinical;clinical application;cofactor;Cognitive;cognitive testing;Complex;Consumption;Data;Deacetylase;Deacetylation;Death Rate;Dose;effective therapy;effectiveness evaluation;efficacy evaluation;Emotional;Enzymes;Estrous Cycle;Failure;Female;Generations;Glutamate-ammonia-ligase adenylyltransferase;Goals;Grant;Heart Arrest;Histologic;Impairment;improved;inhibitor;Injury;insight;Ischemia;Ischemic Brain Injury;knockout animal;male;Metabolism;Mitochondria;Mitochondrial Proteins;Mus;Myocardial Infarction;Nerve Degeneration;Neurologic;Neurological outcome;neuron loss;Neurons;neuroprotection;Nicotinamide Mononucleotide;Ovariectomy;Pathologic;Pathway interactions;Pilot Projects;Poly Adenosine Diphosphate Ribose;Post-Translational Protein Processing;pre-clinical research;preservation;Process;Production;Prosencephalon;protective effect;Protein Acetylation;protein expression;Proteins;Protocols documentation;psychologic;Publishing;Reaction;Recovery;Regulation;Research;Role;SIRT1 gene;Sirtuins;Stroke;stroke outcome;stroke victims;Survivors;Testing;Therapeutic;therapy development;Time;tool;Transgenic Animals;Treatment Efficacy;Treatment Protocols;treatment strategy;Work

PROJECT_TITLE: Using NAD+ precursor for treatment of global cerebral ischemia

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: INDIANAPOLIS

ORG_DEPT: NEUROLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Proposal Narrative  Vascular contributions to cognitive impairment and dementia (VCID) are known to be common causes of dementia yet remain poorly understood. Diffuse white matter disease (DWD) is a common manifestation of small-vessel cerebrovascular pathology and a key subtype of VCID. In these series of studies we propose to determine how placental growth factor (PlGF) causes DWD via formation of new, immature and leaky blood vessels in the brain.

PI_NAMEs: WILCOCK, DONNA M (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Acute;Address;Aging;Algorithms;angiogenesis;Angiogenic Proteins;Animal Model;Antibodies;Astrocytes;Autopsy;Biochemical;Biological Markers;Blood - brain barrier anatomy;Blood Vessels;Brain;cell type;Cells;cerebrovascular;cerebrovascular pathology;Cerebrovascular system;Chronic;Circulation;Clinical;Cognition;cohort;Data;Dementia;Diameter;Diet;Diffuse;digital;digital pathology;Distant;Endothelial Cells;exosome;Extravasation;gray matter;Hemorrhage;Histologic;Histology;Human;Human Characteristics;human model;human tissue;Hyperhomocysteinemia;improved;Individual;Infarction;Inflammation;innovation;interest;intravital imaging;Ischemia;Kentucky;Knockout Mice;Length;Longitudinal cohort;Magnetic Resonance Imaging;Mediating;Mediator;Microglia;Microvascular Dysfunction;Modeling;Molecular;Morphology;mouse model;Mus;Neurons;neuropathology;neurovascular;novel;Oligodendroglia;Pathologic;Pathologic Neovascularization;Pathology;PGF gene;Plasma;Proteins;Quantitative Reverse Transcriptase PCR;Research Personnel;Resources;response;Retinal Diseases;Rodent;Role;Sampling;Series;targeted treatment;Techniques;Testing;Therapeutic Intervention;Time;Tissues;Universities;vascular cognitive impairment and dementia;Ventricular;Western Blotting;white matter;White Matter Disease;Wild Type Mouse

PROJECT_TITLE: Elucidating the role of placental growth factor in diffuse white matter disease


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: HEBREW REHABILITATION CENTER FOR AGED

PHR: Project Narrative Delirium, an acute confusional state, is a common, serious, and potentially preventable condition in the older population, yet our ability to assess the severity of an episode of delirium is not well understood. Because the impact of a delirium episode may be even more important in Alzheimer’s disease and related dementias (ADRD), our goal is to develop new ways to measure delirium severity in persons both with and without ADRD. We cannot manage and treat a condition appropriately until we can measure its impact; thus, this application is a fundamental step to help develop and test new treatments for delirium in persons with and without ADRD, and ultimately, to improve healthcare and quality of life for older persons and their families.

PI_NAMEs: INOUYE, SHARON K. (contact);JONES, RICHARD N

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Acute;acute care;adjudication;advanced dementia;Affect;Alzheimer's disease related dementia;American;associated symptom;Cessation of life;Classification;Clinical;Clinical Trials;clinically relevant;Cognition;Cognitive;cognitive function;cohort;Communication;Complex;Complication;Confusion;cost;Data;Delirium;Dementia;design;Diagnosis;Disease;Distress;Enrollment;Equation;Evaluation;Exclusion;experience;Face;Family;field study;Frequencies;Goals;Health Care Costs;Health care facility;Healthcare;hospital care;Hospitalization;Impaired cognition;improved;Institutionalization;instrument;Length of Stay;Long-Term Care;Measurement;Measures;Medical;Medicine;member;Methods;Monitor;Normal Range;novel;older adult;Older Population;Operative Surgical Procedures;Outcome;Outcome Measure;Participant;Patients;Performance;Persons;Population;prospective;Prospective cohort;Prospective, cohort study;Psychometrics;Publications;Quality of life;Recommendation;Reference Standards;Risk;risk stratification;Sampling;Severities;Site;skills;Subgroup;surgical service;systematic review;Testing;tool;treatment response;Validation;Validity and Reliability;verbal;Work

PROJECT_TITLE: BASILÃÂÃÂÃÂÃÂ Better Assessment of Illness:  Delirium Severity Measures for Persons with and without Dementia

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative The proposed research is aimed at elucidating how the multiple trafficking pathways inside cells are coordinated. Unobstructed flow of proteins and membrane through these pathways is required for proper functioning of all cells during normal growth and under stress, and even minor defects can result in severe acquired and inherited diseases. Conserved small GTPases that function as molecular switches are key regulators of these pathways and we will explore mechanisms by which these GTPases integrate cellular pathways into a dynamic network.

PI_NAMEs: SEGEV, NAVA  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Address;Autophagocytosis;Biochemistry;Biological Models;Cells;Cellular biology;Defect;Disease;Endocytosis;Exocytosis;Formulation;Growth;Guanosine Triphosphate Phosphohydrolases;Hereditary Disease;Human body;Individual;Malignant Neoplasms;Mediating;member;Membrane;Membrane Microdomains;Minor;Molecular;Molecular Genetics;Monomeric GTP-Binding Proteins;Motility;Nerve Degeneration;Neurodevelopmental Disorder;Nucleotides;Pathway interactions;Proteins;Proteome;rab GTP-Binding Proteins;recruit;Research;Stress;System;trafficking;Variant;Vesicle;vesicle transport;Work;Yeast Model System;Yeasts

PROJECT_TITLE: Coordination of intracellular trafficking pathways by Ypt/Rab GTPases and their GEFs.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE  The Penn State Medical Scientist Training Program (MSTP) recruits motivated, diverse students and provides them with exceptional dual degree training in preparation for entering the physician- scientist workforce. This mission will be achieved through our Aims to: (1) Efficiently and effectively teach MSTP students the knowledge and skills to conduct research, with the highest standards of scientific rigor; (2) Train MSTP students through an integrated clinical and research program that will prepare them for their careers; and (3) Promote wellness and resilience in a culture of scholarship, critical thinking, and innovation.

PI_NAMEs: LEVENSON, ROBERT  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: Medical Scientist Training Program

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ORG_CITY: DALLAS

ORG_DEPT: DERMATOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Projective Narrative Improved patient care depends on scientific discovery applied to human conditions. We continue to pursue this goal by recruiting promising individuals to a research fellowship program that trains them effectively at The University of Texas Southwestern Medical Center. Our application for renewed T32 funding will sustain development of scientific investigators and leaders in dermatology.

PI_NAMEs: WANG, RICHARD C (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TITLE: Dermatology Research Training Program