ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Hematology;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Narrative: Studies proposed will elucidate impact of mutant RUNX1 on epigenome/transcriptome, as well as efficacy of novel BETP antagonist-based combinations against AML expressing somatic RUNX1 mutation. These studies will also interrogate the efficacy of novel expression mimickers (EMs) of RUNX1 knockdown, alone or in designated rational combinations, against in vitro and in vivo cellular models of AML expressing somatic or germline mtRUNX1.

PI_NAMEs: BHALLA, KAPIL  (contact);DINARDO, COURTNEY ;FISKUS, WARREN CAMPBELL

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: Age;antagonist;Apoptosis;autosome;Back;BCL1 Oncogene;BCL2 gene;Binding;Biology;Bromodomain;C-terminal;Cell Line;Cell model;Cells;chemotherapy;Chromatin;chromatin protein;cofactor;Complex;Core-Binding Factor;Coupled;CRISPR screen;Dependence;DNA Binding;DNA Polymerase II;Dysmyelopoietic Syndromes;Engraftment;Enhancers;epigenome;Exhibits;Exons;Familial Platelet Disorder;Genes;Genetic Transcription;Germ Lines;Germ-Line Mutation;graft vs host disease;Growth;Hematopoiesis;Hematopoietic stem cells;Heterozygote;homoharringtonine;Homologous Transplantation;improved;In Vitro;in vivo;Induction of Apoptosis;inhibitor;Introns;knock-down;Length;Libraries;loss of function mutation;Malignant - descriptor;Maps;Mediating;Messenger RNA;Mus;mutant;Mutation;Myeloproliferative disease;Network-based;new therapeutic target;novel;novel therapeutics;Oncogenes;Outcome;patient derived xenograft model;Patients;pre-clinical;preclinical efficacy;Prognosis;Protac;Protein Isoforms;Proteins;Reader;recruit;Recurrent disease;Repression;Residual state;Resistance;Risk;RNA;RUNX1 gene;small hairpin RNA;Somatic Mutation;stem cells;targeted treatment;Time;transcription factor;Transcriptional Activation Domain;Transcriptional Regulation;transcriptome

PROJECT_TITLE: Biology and novel therapy of AML expressing somatic or germline mutant RUNX1

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ADMINISTERING_IC: MD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Social Determinants of Health;Suicide;Violence Research;Youth Violence

ORG_CITY: SAINT LOUIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: SOCIAL SCIENCES

ORG_FIPS: US

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Sexual and gender minority (SGM:, e.g., lesbian, gay, bisexual, transgender) adolescents experience disparities in behavioral health outcomes compared to their peers. The goal of this grant is to test the efficacy of a theoretically informed, multi-level school-based intervention for SGM adolescents, Proud & Empowered (P&E). Based upon our extensive preliminary studies and pilot data, we expect that P&E will help to a) reduce minority stress; b) improve behavioral health and coping along SGM; and c) create sustainable change in school climate to improve the health of this high need population of youth.

PI_NAMEs: GOLDBACH, JEREMY THOMAS (contact)

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: Academy;Address;Administrator;Adolescent;Advisory Committees;Affect;Ally;Anxiety;Attitude;Behavior;behavioral health;Belief;bullying;California;Characteristics;Child;Clinical;cohort;Collaborations;community organizations;coping;Data;Development;Disparate;Disparity;Drops;Ecosystem;educational atmosphere;Educational process of instructing;efficacy testing;empowerment;Environment;environmental change;experience;Face;Feasibility Studies;Feeling suicidal;Foundations;Funding;Future;Gays;Gender;gender minority youth;Goals;Grant;group intervention;Guidelines;Health;Heterosexuals;implementation facilitators;implementation fidelity;improved;innovation;Institution;Intervention;intervention effect;Leadership;Learning;Lesbian;Lesbian Gay Bisexual Transgender;Lesbian Gay Bisexual Transgender Queer;Los Angeles;Measures;Mediating;Medicine;Mental Depression;Meta-Analysis;minority stress;minority student;Modeling;novel;Outcome;Participant;peer;Perception;Policies;Population;Post-Traumatic Stress Disorders;Prevention;programs;Psychometrics;Public Health;Randomized, Controlled Trials;Reporting;Research;Resources;Safety;Schools;Science;Self-Injurious Behavior;Sexual and Gender Minorities;sexual disparity;sexual minority youth;sexual victimization;Sexuality;Site;social;Source;Students;substance use;success;suicidal;Suicide attempt;suicide rate;Surveys;Symptoms;teacher;theories;Training;transgender;Treatment Efficacy;United States National Institutes of Health;Victimization;Vulnerable Populations;Work;Youth

PROJECT_TITLE: Efficacy of a Multi-level School Intervention for LGBTQ Youth

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Data Science;Digestive Diseases;Genetics;Human Genome;Orphan Drug;Pancreatic Cancer;Precision Medicine;Rare Diseases

ORG_CITY: STONY BROOK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: Narrative: Pancreatic Ductal Adenocarcinoma (PDAC) takes advantage of its surrounding tissue to promote its malignant growth and evade the immune system. To understand how cellular interactions within the PDAC ecosystem impact clinical outcome, I propose to build and characterize a detailed single-cell transcriptomic atlas of the PDAC microenvironment at an unprecedented spatial and transcriptional detail. This hybrid tumor mapping will serve as a valuable bioinformatic resource by lending researchers the ability to investigate targetable cell signaling interactions within the cancer tissue landscape.

PI_NAMEs: OH, KI  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Algorithms;Atlases;Basic Science;Big Data;bioinformatics resource;Biological;Biology;Cancer Biology;cancer heterogeneity;cancer type;Cell Communication;cell type;Cells;Clinical;clinical prognosis;Clinical Trials;cloud based;Coculture Techniques;Combined Modality Therapy;Communities;Complex;computer infrastructure;Cultured Cells;Data;data exploration;Data Set;data sharing;data visualization;Desmoplastic;Disparity;Drug resistance;Early Diagnosis;Ecosystem;Elements;experimental study;Face;Fibroblast Growth Factor;Fibroblasts;Future;genetic signature;Genetic Transcription;Growth;Heterogeneity;high dimensionality;Histology;Human;Hybrids;Immune;Immune Evasion;Immune system;Immunohistochemistry;Immunosuppression;improved;In Situ Hybridization;In Vitro;in vivo;insight;Insulin-Like Growth Factor I;Intuition;laser capture microdissection;Lymphocyte;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;Measurement;Meta-Analysis;Microdissection;Minor;Molecular Analysis;Molecular Profiling;molecular subtypes;multidimensional data;multimodality;Mus;Myelogenous;Nature;Neoplasm Metastasis;neoplastic;neoplastic cell;novel;Oncology;Organoids;Outcome;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;paracrine;Pathology;Pathway interactions;patient stratification;Patient-Focused Outcomes;Patients;personalized medicine;Pharmaceutical Preparations;Phenotype;Population;precision medicine;Production;Prognosis;prognostic;Protein Secretion;Reproducibility;Research;Research Personnel;Resistance;Resolution;Resources;Role;Sampling;Signal Transduction;single cell analysis;single cell sequencing;single-cell RNA sequencing;Solid;Source;standard care;Stromal Cells;Testing;TGFB1 gene;Therapeutic;Therapeutic Intervention;therapeutic target;therapeutically effective;Time;Tissues;transcriptome sequencing;transcriptomics;Translational Research;treatment group;treatment response;tumor;tumor microenvironment;Tumor Promotion;Tumor Subtype;Validation;virtual;wasting;web platform;Work;Xenograft procedure

PROJECT_TITLE: Single Cell Deconvolution of the Pancreatic Tumor Microenvironment


ADMINISTERING_IC: AA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

ORG_CITY: NEW ORLEANS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: Project Narrative LSUHSC CARC Overall The Louisiana State University Health Sciences Center New Orleans Comprehensive Alcohol-HIV/AIDS Research Center (LSUHSC-NO CARC) is a multi-institutional, multidisciplinary team of scientists focused on understanding the interaction of alcohol use disorders, human immunodeficiency virus, and antiretroviral therapy. CARC activities encompass clinical and mechanistic bidirectional translational studies, training, mentoring, and information dissemination.

PI_NAMEs: MOLINA, PATRICIA E. (contact)

PROGRAM_OFFICER_NAME: LIN, LI

PROJECT_TERMS: Acceleration;Address;Affect;Age;Aging;alcohol consequences;Alcohol consumption;alcohol effect;alcohol exposure;alcohol risk;alcohol use disorder;Alcohols;antiretroviral therapy;Automobile Driving;Behavior;Behavioral;Behavioral Research;Biological Process;Biomedical Research;career development;Caring;Cell Aging;Cell Death Induction;Center for Translational Science Activities;Chronic;Clinical;Clinical Research;clinically relevant;cohort;Communities;comorbidity;Control Groups;Data;Data Analyses;data management;demographics;Development;Diet;Disadvantaged;Disease;Enrollment;Ensure;Environment;Environmental Risk Factor;Equilibrium;Evolution;experience;Exposure to;Funding;Gut Mucosa;Health;Health Sciences;Healthcare;HIV;HIV/AIDS;immune activation;Immunologics;immunosenescence;Individual;Inflammation;Inflammatory;Information Dissemination;Infrastructure;Institution;Intestinal Mucosa;Investigation;Knowledge;Longitudinal cohort;Longitudinal Studies;Louisiana;Mentors;Metabolic;Minority Groups;Modeling;Mucous Membrane;multidisciplinary;Neighborhoods;Neurologic Deficit;nonhuman primate;novel;organizational structure;Oxidative Stress;Pathway interactions;Persons;Physical activity;Pilot Projects;Play;Population;preclinical study;Primates;Productivity;programs;Public Health Schools;Publishing;Research;research facility;Research Personnel;Resources;Risk;Role;Scientist;senescence;Severities;sex;Site;SIV;social factors;Stress;stressor;substance use;synergism;tissue injury;Training;Translational Research;translational study;Translations;Tropical Medicine;underserved minority;Underserved Population;Universities;urban area;Viral

PROJECT_TITLE: LSUHSC-NO Comprehensive Alcohol-HIV/AIDS Research Center


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;HIV/AIDS;Infectious Diseases;Substance Misuse

PROJECT_TERMS: Address;Alcohol abuse;alcohol consequences;Alcohol consumption;alcohol research;Alcohols;Applications Grants;Area;Biometry;Budgets;clinically relevant;Collaborations;Communities;comorbidity;Consultations;cost effective;Data;Data Collection;data management;Department chair;Development;Disease;disorder prevention;Drug abuse;Education;Ensure;evidence base;Experimental Designs;Extramural Activities;Faculty;Fertilization;Fostering;Funding;Goals;Health;Health Personnel;Health Sciences;HIV;HIV/AIDS;Human Resources;improved;Incidence;Individual;Informatics;Infrastructure;innovation;Institution;Intervention;Investigation;Knowledge;Leadership;lectures;Logistics;Louisiana;Manuscripts;medical schools;Medicine;member;Mentors;Monitor;multidisciplinary;operation;Outcome;Participant;Patient Care;Peer Review;Performance;Persons;Phase;Physiology;Pilot Projects;Preparation;Primary Care;Primates;Principal Investigator;Productivity;professor;programs;psychosocial;Public Health Schools;Publications;Publishing;Research;Research Personnel;Research Priority;Research Project Grants;research study;Resources;Role;Science;Scientist;Secure;Series;Statistical Data Interpretation;Structure;success;Training;training opportunity;Translational Research;transmission process;United States National Institutes of Health;Universities;Viral;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_CITY: AMHERST

ORG_DEPT: DENTISTRY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative Periodontitis is a common inflammation of the tooth supporting tissues due to infection by a select group of bacterial pathogens. It can lead to tooth loss in adults and also impact systemic health. The objective of this project is two-fold: to understand how pathogen secreted sialidase enzymes – which can release sialic acid sugar from host components – influence periodontitis, and perform proof-of-concept studies in mice to assess if FDA-approved inhibitors of this enzyme can prevent periodontitis in humans.

PI_NAMEs: SHARMA, ASHU  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Acetylesterase;Acute;Address;Adult;Affect;Amino Sugars;Anabolism;Antibiotic Therapy;Back;Bacteria;Bacterial Adhesion;bacterial resistance;Biota;CD14 gene;Cell Communication;Cell Wall;Cells;Complex;cytokine;Dependence;Development;Disease;Disease Outcome;dysbiosis;Ecology;Economic Burden;Enzyme Inhibitor Drugs;Enzymes;Epithelial Cells;Excision;FDA approved;fitness;Flagellin;Forsythia;Genome;Gingiva;Gingival Crevicular Fluid;Glycoproteins;Growth;Health;Human;Immune;Immune response;Immunity;Immunologic Factors;improved;in vivo;Infection;Inflammation;Inflammatory;Influentials;inhibitor;inhibitor therapy;Innate Immune Response;insight;Invaded;Knowledge;Ligands;Medical;Metabolic;microbial;Microbial Biofilms;Microbiology;microbiota;Mining;Molecular;mouse model;Mucin 1 protein;Mus;N-acetylmuramic acid;Natural Immunity;Nature;Neuraminidase;novel;Nutrient;Oral;oral bacteria;Organism;Orthologous Gene;Oseltamivir;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Patients;Peptidoglycan;Periodontal Diseases;Periodontitis;Periodontium;periodontopathogen;Persons;Pharmaceutical Preparations;pharmacologic;Physiology;Play;Polysaccharides;Porphyromonas gingivalis;prevent;Process;Proteins;Recombinants;Regulation;Resistance;response;Risk Factors;Role;Saliva;Salivary;salivary mucins;Serum;sialate;Sialic Acids;Sialoglycoproteins;sialylation;Signal Transduction;Site;Specificity;Streptococcus oralis;Structure;subgingival microbiota;Sugar Acids;Surface;synergism;System;Systemic disease;targeted treatment;Testing;therapeutic evaluation;Tissues;Tooth Loss;Tooth structure;Topical application;Treponema denticola;Virulence;Work

PROJECT_TITLE: Bacterial sialometabolic activity impacts periodontal immunity and microbiota

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;HIV/AIDS;Infectious Diseases;Substance Misuse

PI_NAMEs: SIMON, LIZ  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Adult;Adverse effects;Affect;Age;Age related comorbidities;Aging;alcohol comorbidity;Alcohol consumption;alcohol exposure;alcohol risk;alcohol use disorder;Alcohols;analytical tool;animal care;antiretroviral therapy;Behavioral;biobank;Biological;Biological Assay;Caring;Center for Translational Science Activities;Chronic;Clinical;Clinical Data;Clinical Research;Clinical Sciences;cohort;Communities;community engagement;comorbidity;Complement;Consumption;Data;Databases;design;Dietary Practices;Enrollment;Ensure;Environmental Risk Factor;Ethics;experience;Experimental Designs;Extramural Activities;Funding;Guidelines;Health;Health Sciences;Healthcare;HIV;HIV/AIDS;Human;Human Resources;human subject;Human Subject Research;Individual;instrumentation;Investigation;Longitudinal Studies;Louisiana;Macaca mulatta;male;Measures;Mediating;Mediator;Methodology;Mission;Modeling;National Institute on Alcohol Abuse and Alcoholism;NCI Center for Cancer Research;next generation;nonhuman primate;novel;Older Population;Outcome;Pathway interactions;Performance;Persons;Pilot Projects;Postdoctoral Fellow;Pre-Clinical Model;pre-clinical research;pre-doctoral;preclinical study;Procedures;Process;Protocols documentation;Quality Control;recruit;Regimen;Reproducibility;Research;Research Personnel;Research Project Grants;research study;Research Support;Resources;Risk;Sampling;Services;SIV;Social Environment;social factors;Specimen;Study models;Study Subject;synergism;Teacher Professional Development;Testing;Time;Training;translational potential;Translational Research;translational scientist;translational study;United States National Institutes of Health;Universities;Update;Vertebrates

PROJECT_TITLE: Experimental and Analytical Resource Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE  Colorectal cancer is the 2nd leading cause of cancer death, and despite effective methods for prevention and early detection, screening rates remain low. Recent insights from behavioral economics have shown that reducing effort and providing timely nudges can encourage clinicians and patients to engage with preventive health activities. We will conduct a pragmatic trial evaluating if offering a sequential choice of screening options during clinic visits and through direct patient outreach can increase colorectal cancer screening completion.

PI_NAMEs: MEHTA, SHIVAN JATIN (contact)

PROGRAM_OFFICER_NAME: WEAVER, SALLIE JAYNE

PROJECT_TERMS: Address;Architecture;Behavior;behavioral economics;Cancer Etiology;Caring;Cessation of life;Clinic Visits;Colonoscopy;Colorectal Cancer;colorectal cancer screening;design;Dimensions;Early Diagnosis;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;Electronic Health Record;ethnic disparity;ethnic minority;evidence base;Fatigue;Friction;Goals;Guidelines;Health;health care delivery;Health Promotion;Health system;Home;Human;Individual;Industry;insight;Intervention;Interview;Medical;member;Methods;Office Visits;outreach;patient outreach;Patients;Pennsylvania;Policies;population based;Pragmatic clinical trial;pragmatic trial;Prevention;Prevention strategy;Preventive;primary care practice;primary care provider;primary outcome;Procedures;Process;programs;provider factors;racial disparity;racial minority;Randomized;Recommendation;Risk;routine care;screening;screening program;shared decision making;Surveys;System;Test Result;Testing;Time;United States;Universities;uptake;Visit;Work

PROJECT_TITLE: Behavioral Economic Approaches for Population-based Colorectal Cancer Screening

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;HIV/AIDS;Infectious Diseases;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Substance Misuse;Underage Drinking

PI_NAMEs: EDWARDS, SCOTT  (contact)

PROJECT_TERMS: Achievement;AIDS education;Alcohol abuse;alcohol consequences;Alcohol consumption;alcohol effect;alcohol research;alcohol use disorder;Alcoholism;Alcohols;Area;Awareness;Basic Science;Behavior Therapy;Behavioral;Biological;career;Categories;Clinical Research;Collaborations;Communication;Communities;Community Health Education;Community Outreach;comorbidity;condoms;Consequences of HIV;Dental;Discipline of Nursing;doctoral student;Education;Educational Activities;empowerment;evidence base;Extramural Activities;Faculty;Fostering;Funding;Future;Goals;Health;Health Knowledge Attitudes Practice;health literacy;Health Occupations;Health Personnel;Health Sciences;Healthcare;Hepatitis C;High Risk Woman;HIV;HIV/AIDS;improved;Individual;Information Centers;Information Dissemination;Institution;interest;International;Knowledge;Learning;Louisiana;Medical;meetings;Minority;Minority Groups;minority student;Mission;multidisciplinary;Neurobiology;optimism;outreach;Persons;Pharmacy Students;Physical therapy;Population;Populations at Risk;Primary Schools;Printing;programs;psychosocial;Publishing;recruit;Research;Research Personnel;Resistance;Resources;Risk;Risk Factors;Schools;Scientist;skills;Societies;Students;symposium;Target Populations;Training;Training and Education;Training Programs;Translations;transmission process;treatment adherence;underserved minority;Universities;Viral Load result;Woman;Youth

PROJECT_TITLE: Information Dissemination Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative This proposal is aimed at a better understanding of how the brain controls food intake and body weight through a newly identified neural circuit in response to external stimuli and calorie-dense foods. Here, we begin to identify two distinct group of neurons from a defined brainstem neural circuit that elicit complementary roles in regulation of feeding behavior and obesity. The expected outcome would facilitate the discovery of new, brainstem targets for therapeutic weight-management strategy.

PI_NAMEs: WU, QI  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Affect;Anabolism;Appetitive Behavior;Behavior;Behavioral;Behavioral Paradigm;Biological Assay;Body Weight;brain control;Brain region;Brain Stem;Calories;cell type;Cognitive;cohort;Consumption;Coupling;CRISPR/Cas technology;Data;Desire for food;Dopamine;dopaminergic neuron;DRD1 gene;Eating;Electrophysiology (science);Elements;Exhibits;feeding;Feeding behaviors;Food;gain of function;gamma-Aminobutyric Acid;Gene Targeting;Genes;Genetic;Genetic Suppression;High Fat Diet;hindbrain;Hyperphagia;in vivo;Individual;innovation;interdisciplinary approach;Learning;loss of function;Maps;Mediating;Mediation;mesolimbic system;Modeling;Motivation;neural circuit;neuromechanism;Neurons;new therapeutic target;novel;Nucleus Accumbens;Nutritional;Obesity;obesity treatment;optogenetics;Outcome;parabrachial nucleus;Pattern;permissiveness;Physiological;Play;Population;postsynaptic;preference;Process;Psychological reinforcement;Regulation;response;Rewards;Role;Satiation;Satiety Response;Signal Transduction;Solid;Stereotyping;Stimulus;Substantia nigra structure;System;targeted treatment;Taste Perception;Techniques;Testing;Time;tool;Ventral Tegmental Area;Viral;Virus;Weight maintenance regimen

PROJECT_TITLE: Diverse control of motivational and consummatory feeding by a hindbrain dopaminergic neural circuit

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Social Determinants of Health;Substance Misuse

PI_NAMEs: FERGUSON, TEKEDA F. (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adult;Age;Aging;alcohol comorbidity;Alcohol consumption;alcohol effect;alcohol risk;alcohol use disorder;Alcohols;antiretroviral therapy;Basic Science;Behavioral;behavioral and social science;Behavioral Mechanisms;Biological;cardiometabolism;Cardiovascular Diseases;care outcomes;Caring;Chronic;Chronic Disease;Clinical;Clinical Data;Cognitive;cohort;Communities;comorbidity;comparison group;Continuity of Patient Care;coping mechanism;Data;Death Rate;Diabetes Mellitus;Discrimination;Disease Management;Disease Progression;Distal;Elderly;Ensure;Environmental Risk Factor;Epidemiology;evidence base;experience;Exposure to;frailty;General Population;Geography;Goals;Health;Health behavior;health disparity;Healthcare;high risk;HIV;HIV anti-retroviral;HIV/AIDS;Household;housing instability;immunological status;improve minority health;improved;Individual;Infrastructure;Intervention;Kidney Diseases;Knowledge;Life Expectancy;Link;Malignant Neoplasms;Measurable;Mediating;Mediation;Mental Health;Metabolic;minority communities;Mission;Modeling;National Institute on Alcohol Abuse and Alcoholism;Neighborhoods;Neurocognitive Deficit;novel;Osteoporosis;Outcome;Participant;Pathway interactions;Persons;Physiological;Play;Population;psychiatric comorbidity;Psychosocial Stress;Public Health;Quality of life;Research;Risk;Role;Science;Secondary Prevention;Shapes;social determinants;Social Environment;social space;Social support;socially disenfranchised;Space Models;Stress;stressor;success;Syndrome;Techniques;Testing;Time;Translations;United States;Viral Load result;Virus Diseases;Vulnerable Populations

PROJECT_TITLE: Community and Interpersonal Stress, Alcohol, and Chronic Comorbidities among PLWH


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Nanotechnology;Orphan Drug;Ovarian Cancer;Pancreatic Cancer;Rare Diseases;Women's Health Research

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: When exposed to biological fluids nanoparticles (NPs) interact with proteins forming a biological coating on their surface, termed protein corona. In the current application, exploiting self-therapeutic GNP (ST-GNP) as a probe, we are proposing a unique concept of capturing, identifying and validating therapeutic targets responsible for tumor growth and therapy resistance in cancer.

PI_NAMEs: BHATTACHARYA, RESHAM ;MUKHERJEE, PRIYABRATA  (contact)

PROGRAM_OFFICER_NAME: AVULA, LEELA RANI

PROJECT_TERMS: Address;Adsorption;Angiogenesis Inhibition;Animal Model;Binding;Biodistribution;Bioinformatics;Biological;Biological Models;Biological Process;cancer cell;Cells;Cisplatin;clinically significant;Coupled;Data;Databases;delivery vehicle;Diabetic Retinopathy;Disease;Disease Outcome;Drug resistance;drug-sensitive;Epithelium;experimental study;Exposure to;Fibroblasts;Gold;Heparin Binding Growth Factor;Human;In Vitro;in vivo;Incubated;inhibitor therapy;insight;Intervention;liposomal delivery;Liquid substance;Macular degeneration;Malignant - descriptor;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;MAP Kinase Gene;Mass Spectrum Analysis;Mesenchymal;Methodology;Modeling;Molecular Conformation;nanoGold;nanoparticle;nanotoxicity;Neoplasm Metastasis;Nodal;Normal Cell;novel;ovarian neoplasm;pancreatic cancer model;Patients;personalized medicine;Plasma;Process;Property;Protein Conformation;protein distribution;protein function;Proteins;Reporting;Resistance;response;Rheumatoid Arthritis;Scheme;Sequence Homology;Series;Signal Transduction;siRNA delivery;Small Interfering RNA;small molecule inhibitor;Surface;Testing;Therapeutic;therapeutic nanoparticles;therapeutic target;Tissues;Toxic effect;Treatment Efficacy;tumor growth;tumor microenvironment;Tumor Promotion;Tumor Tissue;Validation

PROJECT_TITLE: Exploiting gold nanoparticle as a probe to identify therapeutic targets

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Clinical Research;Diabetes;HIV/AIDS;Infectious Diseases;Nutrition;Obesity;Substance Misuse

PROJECT_TERMS: Adipose tissue;Adult;Affect;Age Years;Alcohol consumption;alcohol risk;Alcohols;American;antiretroviral therapy;Back;Behavior;Biological Markers;Body mass index;bone;Brain;Calories;Caring;Cholesterol;Chronic;Chronic Disease;Clinical;Clinical Data;comorbidity;Consumption;Data;Death Rate;diabetic;Diet;Diet Habits;dietary;dietary control;Energy Metabolism;Enrollment;Environment;euglycemia;Fasting;Fatty acid glycerol esters;glucose tolerance;Health;Health Sciences;Healthy Eating;High Prevalence;HIV;HIV Infections;HIV/AIDS;Hour;immune activation;Impairment;In Vitro;in vivo;Incidence;indexing;Infrastructure;Intestines;Link;Liver;Longevity;Longitudinal Studies;Louisiana;Macaca;Macronutrients Nutrition;Measures;Metabolic;Metabolic syndrome;Modeling;Muscle;nonhuman primate;Obesity;Odds Ratio;OGTT;oral glucose tolerance;Organ;Overweight;Pancreas;Participant;Pathogenesis;Persons;phosphatidylethanol;pre-clinical;Prediabetes syndrome;Publishing;Reporting;Research;Research Personnel;response;Risk;SIV;synergism;targeted treatment;Techniques;Testing;Therapeutic Intervention;therapy adverse effect;Time;timeline;translational approach;translational study;United States;Universities;Viral;Visceral;western diet

PROJECT_TITLE: Alcohol and Metabolic Dysregulation in PLWH: Mechanisms Underlying Risk for Comorbidities


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Women's Health Research;Wound Healing and Care

ORG_CITY: LEXINGTON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Clinical prognoses after surgical breast reconstruction often involve mastectomy skin flap necrosis or other complications associated with lack of blood flow and oxygenation to wound tissue volumes. The objective of this project is to design and optimize a novel noninvasive optical imaging technique, which will enable rapid online 3D imaging of both blood flow and oxygenation distributions throughout the entire volume of mastectomy skin flaps to perioperatively assess ischemic-hypoxic tissue regions/volumes. Outcomes from this translational study in swine and patients undergoing mastectomy with expander-implant based breast reconstruction will provide essential information for intraoperative guidance of compromised tissue excision and postoperative optimization of incremental expander fill volumes to reduce postmastectomy complications and healthcare costs.

PI_NAMEs: YU, GUOQIANG  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: Adjuvant Therapy;Algorithms;Area;Blood;Blood capillaries;Blood flow;Body Image;Brain;Brain Hypoxia-Ischemia;Breast;breast surgery;Burn injury;Calibration;Clinical;clinical prognosis;Clinical Trials;Color;cost efficient;Dermal;design;Development;Devices;Diffuse;diffuse optical spectroscopy and imaging;Distress;Dyes;Ensure;Esthetics;Excision;Family suidae;Fluorescence;Fluorescence Angiography;Health Care Costs;hemodynamics;Hemorrhage;Heterogeneity;Human;Image;image reconstruction;imager;imaging system;Imaging Techniques;Implant;in vivo;Incidence;Indocyanine Green;innovation;Interruption;Judgment;Laboratories;Lateral;Malignant Breast Neoplasm;Mammaplasty;Maps;Mastectomy;Measurement;Measures;Metabolic;Monitor;multimodality;Necrosis;next generation;non-invasive optical imaging;novel;operation;Operative Surgical Procedures;Optics;Outcome;Outcome Study;Oxygen;Patients;Pattern;Perfusion;Perioperative;Postoperative Complications;Postoperative Period;preclinical study;preservation;prevent;prototype;Quality of life;Risk;Risk Reduction;Rodent;self esteem;Sexuality;Skin;Speed;Surface;Surgeon;surgery outcome;System;Techniques;Technology;Temperature;Testing;Thick;Three-Dimensional Image;Three-Dimensional Imaging;Tissue imaging;Tissues;tomography;translational study;Woman;women's diagnosis;wound;wound treatment

PROJECT_TITLE: Perioperative Diffuse Optical Imaging of Tissue Blood Flow and Oxygenation for Optimization of Mastectomy Skin Flap Viability

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cancer;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases;West Nile Virus

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Narrative The mechanism by which viruses enter cells determines crucial aspects of cell tropism, host range, and ultimately pathogenesis. We combine advanced methods in cryo-EM and live-cell imaging to determine molecular mechanisms of entry for broad classes of viruses, using two groups of major human pathogens -- flaviviruses and rotaviruses -- as models.

PI_NAMEs: HARRISON, STEPHEN COPLAN (contact)

PROGRAM_OFFICER_NAME: COUCH, JENNIFER A

PROJECT_TERMS: Capsid;Cell membrane;Cell surface;cell type;Cell-Matrix Junction;Cells;Chimeric Proteins;Collaborations;Coupled;Cryoelectron Microscopy;Crystallography;Cytosol;Data;Dengue Virus;design;Detection;Dimensions;Double Stranded RNA Virus;E protein;Electron Microscopy;Electrons;Elements;Event;Experimental Designs;experimental study;Flavivirus;flavivirus glycoprotein E;Fluorescence Microscopy;Foundations;Goals;Grant;human pathogen;imaging study;In Vitro;Infection;Ions;Label;Light;Lipid Bilayers;Liposomes;live cell imaging;Mediating;Membrane;Membrane Fusion;Membrane Proteins;Methods;Microscopy;Modeling;Molecular;Molecular Conformation;movie;Mutation;novel strategies;Outcome Study;particle;Pathogenesis;Pathway interactions;Penetration;Perforation;Process;Productivity;Property;Proteins;Recombinant Proteins;recombinant virus;Recombinants;reconstitution;Resolution;Rhesus;RNA chemical synthesis;RNA Viruses;Rotavirus;single molecule;Site;Structure;System;Testing;Time;Tropism;uptake;Viral;Viral Proteins;Virion;Virus;Virus Assembly;Virus-like particle;Visualization;West Nile virus;Work

PROJECT_TITLE: Structure and Assembly of Viruses

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Depression;HIV/AIDS;Infectious Diseases;Mental Health;Neurosciences;Pain Research;Substance Misuse

PROJECT_TERMS: alcohol consequences;Alcohol consumption;alcohol exposure;alcohol risk;alcohol use disorder;Alcohols;antiretroviral therapy;Area;Behavior;behavior measurement;Behavioral;Brain;Central Nervous System;Characteristics;Chemosensitization;Chronic;chronic pain;Cognition;Cognitive;Cognitive deficits;Consumption;Data;Decision Making;Dendritic Spines;depressive symptoms;Disease;Disease Outcome;Disease Progression;drinking;Electrophysiology (science);emotional functioning;executive function;Experimental Designs;Failure;Glucocorticoid Receptor;Glucocorticoids;Goals;Heavy Drinking;HIV;HIV Infections;HIV-associated neurocognitive disorder;HIV/AIDS;Human;Hyperalgesia;Impaired cognition;Impulsivity;Individual;interest;Investigation;Link;Measures;Mental Depression;Modeling;Morphology;Motivation;negative affect;Negative Reinforcements;Nervous System Trauma;neuroadaptation;Neuroanatomy;Neurobiology;Neurocognitive;Neurocognitive Deficit;Neurologic;Neurologic Deficit;Neurologic Symptoms;neuronal circuitry;Neurons;Neuropathy;Nociception;nonhuman primate;Pain;pain sensitivity;pain symptom;Pathology;Patients;Peripheral;Peripheral Nervous System;Persons;Physical Function;Population;Positioning Attribute;preclinical study;Prefrontal Cortex;Process;Property;psychiatric comorbidity;psychological distress;Psychosocial Factor;Receptor Signaling;Recurrent disease;Research;Short-Term Memory;Signal Transduction;SIV;Slice;Stress;symptomatology;Synapses;System;Techniques;Testing;therapy adherence;United States;Virus Diseases;western diet

PROJECT_TITLE: Alcohol Use Disorder and Associated Neurological Symptoms of Cognitive Dysfunction and Pain


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Hematology;Immunotherapy;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The aims described in this application seek to determine novel mechanisms of group 1 ILC dysregulation in acute myeloid leukemia (AML). We propose an innovative approach to discover the mechanism(s) leading to expanded ILC1 populations in AML and to determine the functional significance of these expanded populations on overall disease progression. Successful completion of these studies will address critical knowledge gaps in our understanding of how ILCs function in disease states, especially the setting of AML.

PI_NAMEs: LORDO, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Adoptive Transfer;Affect;Agonist;Area;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Biological Assay;Biology;cancer cell;Cell Line;Cell Lineage;Cell Maturation;Cell Physiology;cell type;Clinical;Clinical Research;Coculture Techniques;conditional knockout;cytokine;cytotoxic;Data;Defect;design;Detection;Development;Disease;Disease Progression;Family;Future;Genes;Goals;Growth;Hematologic Neoplasms;Homeostasis;Human;Hyperactivity;Immune Evasion;immunodeficiency;Immunologic Surveillance;Immunotherapy;improved;in vivo;inhibitor;innovation;Interleukin-2;Knockout Mice;Knowledge;Label;leukemia;Leukemic Cell;Ligands;Lymphoid Cell;Maintenance;Malignant - descriptor;Malignant Neoplasms;Measures;member;Modeling;mouse model;Mus;Myeloid Cells;Natural Killer Cells;novel;older patient;Outcome;Pathologic;Pathway interactions;patient derived xenograft model;Patients;pharmacologic;Phenotype;Play;Population;Proliferating;Publishing;Receptor Activation;Receptor Inhibition;Receptor Signaling;Regulatory T-Lymphocyte;Relapse;Research;Role;Solid Neoplasm;stem cells;Support Groups;Survival Rate;T-Cell Development;T-Cell Proliferation;targeted treatment;Testing;Therapeutic;Tissues;transcription factor;Transgenic Mice;Treatment Efficacy;tumorigenic

PROJECT_TITLE: Group 1 Innate Lymphoid Cell Dysregulation in Acute Myeloid Leukemia


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Substance Misuse

PI_NAMEs: WELSH, DAVID A (contact)

PROJECT_TERMS: age acceleration;Aging;Alcohol consumption;alcohol exposure;alcohol use disorder;Alcohols;antiretroviral therapy;Apoptosis;Behavior;biological age;Biological Aging;Cardiometabolic Disease;Cardiovascular Diseases;CD8-Positive T-Lymphocytes;Cell Aging;Cell Death Induction;Cell Proliferation;Chronic;Chronic Disease;Clinical;comorbidity;Continuity of Patient Care;Cross-Sectional Studies;early onset;Economics;Elderly;Epidemic;evidence base;exhaustion;Face;frailty;Functional disorder;Goals;Health;Health behavior;health disparity;Health Sciences;High Prevalence;HIV;HIV Infections;HIV Seronegativity;HIV Seropositivity;HIV/AIDS;Immune;immune activation;Infection;Inflammatory;Interruption;life span;longitudinal analysis;Longitudinal Studies;Louisiana;Malignant Neoplasms;Mediating;Mediator;Modeling;multiple chronic conditions;nonhuman primate;Organ;Outcomes Research;Participant;Pathogenesis;Persons;Phenotype;programs;Proliferating;Pulmonary Emphysema;Research;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;SIV;social;substance use;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic Intervention;Tissues;translational study;Universities;Validation;Viral

PROJECT_TITLE: Alcohol, Immune Activation, Senescence, and Activation Induced Cell Death in PLWH


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHICAGO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Relevance: The ability of cells to migrate through junctional barriers is important during tissue morphogenesis, tissue homeostasis and during cancer metastasis. The goal of this project is to understand the molecular regulation of microtubule acetylation and vertex strength during migration and intercalation in a reproducible 3 dimensional in vivo system.

PI_NAMEs: MITCHELL, BRIAN JOSEPH (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TITLE: Molecular Regulation of Radial Intercalation

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Patient Safety;Pediatric;Pediatric - AIDS;Rare Diseases;Tuberculosis;Women's Health Research

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative The expertise provided by the Statistical and Data Management Center will help advance research concerning the treatment of infants, children, adolescents, pregnant and breastfeeding women living with HIV and co-infections such as tuberculosis. It will achieve this by ensuring that IMPAACT clinical trials and other studies are designed, conducted, and analyzed efficiently and to the highest standards using state-of-the-art, compliant clinical and laboratory information management systems that ensure complete and high-quality data. This research will continue to make significant contributions in advancing optimal treatment of infants, children, adolescents, pregnant and breastfeeding women living with HIV both in the United States and internationally.

PI_NAMEs: COOPER, MARLENE ANN;SHAPIRO, DAVID ERIC (contact)

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adolescent;AIDS clinical trial group;antiretroviral therapy;Area;Biometry;Boston;Breast Feeding;Child;Childhood;Clinical;Clinical Trials;Clinical Trials Network;Clinical Trials-Pediatric AIDS;co-infection;Collaborations;Communities;Data;Data Analyses;Data Collection;data communication;Data Coordinating Center;data management;Data Management Resources;data sharing;Databases;design;Development;Diagnosis;Disease remission;Ensure;Epidemiologist;Epidemiology;experience;flexibility;Foundations;frontier;Funding;Future;high standard;HIV;HIV Infections;HIV/AIDS;improved;Industry Standard;Infant;Information Dissemination;Infrastructure;innovation;interest;International;International Aspects;International Maternal Pediatric Adolescent AIDS Clinical Trials;Intervention;Laboratories;Lead;Leadership;Life;Management Information Systems;Methods;Mission;Monitor;National Institute of Allergy and Infectious Disease;novel;optimal treatments;organizational structure;pregnant;Prevention;Procedures;Public Health Schools;Reporting;Request for Applications;Research;research and development;Research Design;Research Personnel;Research Priority;Role;Science;Site;Specimen;Statistical Data Interpretation;System;Technology;Therapeutic Clinical Trial;Training;Tuberculosis;tuberculosis treatment;United States;Woman;Work

PROJECT_TITLE: SDMC - IMPAACT Leadership Group


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Aging;Brain Disorders;Digestive Diseases;Endocrine Disruptors;Microbiome;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Parkinson’s disease (PD) is a debilitating neurodegenerative disease that affects ~1 million individuals and their families nationally. The majority of PD incidences are idiopathic, and pesticide exposures are thought to be a contributing factor to disease etiopathogenesis. This project will explore the interaction of environmental exposures and the microbiome in outcomes of PD-relevant pathologies, with the goal of providing insight into how the indigenous gut microbial community modifies environmental signals leading to brain pathology.

PI_NAMEs: SAMPSON, TIMOTHY ROBERT (contact)

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: Acceleration;Acute;Affect;alpha synuclein;Animal Model;Architecture;Bacterial Genes;Brain Pathology;Cell Survival;Central Nervous System;Colon;Constipation;Data;decamethrin;Disease;disease diagnosis;dopamine system;dopaminergic neuron;dysbiosis;enteric infection;Enteric Nervous System;Enteroendocrine Cell;Environment;Environmental Exposure;Epidemiology;Etiology;Exhibits;Experimental Models;Exposure to;Family;Foundations;Functional disorder;gastrointestinal;gastrointestinal system;Gastrointestinal tract structure;gene environment interaction;Genes;Genetic Risk;Germ-Free;Gnotobiotic;Goals;gut inflammation;gut microbiome;gut microbiota;Human;Immune;Impairment;Incidence;Indigenous;Individual;Inflammation;Inflammatory Bowel Diseases;inflammatory modulation;Inflammatory Response;insight;Intestinal Motility;Intestinal permeability;Intestines;Lactobacillus;Link;Mediating;Microbe;microbial;microbiome;microbiome alteration;microbiome components;microbiome composition;Molecular;monoamine;Motility;motor disorder;mouse model;Mus;Nerve Degeneration;nerve supply;Neurodegenerative Disorders;neuron loss;Neurons;Neuropeptides;nigrostriatal system;Oral;Organ;Outcome;overexpression;Pain;Parkinson Disease;Parkinsonian Disorders;Pathology;Peripheral;pesticide exposure;Pesticides;Physiological;Population;Primates;Production;pyrethroid;Resistance;Risk;Risk Factors;Rodent;Role;Rotenone;Severity of illness;Shapes;Signal Transduction;sporadic Parkinson's Disease;Taxonomy;Testing;tool;Toxic Environmental Substances;Toxicant exposure;Transgenic Mice;Xenobiotic Metabolism

PROJECT_TITLE: Interaction of Pyrethroid Exposure and the Microbiome on Parkinson's Disease related Pathologies

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Pediatric;Rare Diseases

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: PUBLIC HEALTH RELEVANCE STATEMENT  Genetic mutations in the elastin gene cause reduced elastin protein levels and lead to severe narrowing (stenosis) of the aorta through a mechanism that is not well understood. The project will determine how mechanotransduction in smooth muscle cells within the aortic wall is modified by reduced elastin levels and how the resulting downstream signals may contribute to aortic narrowing. The results may lead to new therapeutic strategies to slow or prevent supravalvular aortic stenosis in humans.

PI_NAMEs: WAGENSEIL, JESSICA  (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Affect;Antibodies;Aorta;Aortic Valve Stenosis;Biological;Blood Pressure;Calcium;Calcium Signaling;Cardiovascular Diseases;cell dedifferentiation;cell type;Characteristics;Chemicals;Child;Collagen;Data;Deposition;Development;DNA Sequence Alteration;Elasticity;Elastin;Extracellular Matrix;Extracellular Matrix Proteins;Genes;genetic association;genetic manipulation;Genetic Transcription;Heart failure;hemodynamics;Human;In Vitro;in vivo;induced pluripotent stem cell;Ion Channel;Measures;Mechanics;mechanotransduction;migration;Modulus;mouse model;Mus;Mutation;novel therapeutic intervention;Nuclear Translocation;Operative Surgical Procedures;overexpression;Patients;Pharmacologic Substance;Phenotype;Physiological;Piezo 1 ion channel;Piezo 2 ion channel;Piezo ion channels;prevent;Proliferating;Property;Proteins;public health relevance;Repeat Surgery;response;Risk;Role;Severities;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Smooth Muscle Myocytes;Stenosis;Stress;Stretching;sudden cardiac death;Supravalvular aortic stenosis;Thoracic Aortic Aneurysm;Time;Vascular Diseases

PROJECT_TITLE: Investigating altered smooth muscle cell mechanotransduction as a cause of supravalvular aortic stenosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Cardiovascular;Heart Disease;Immunotherapy;Neurosciences;Precision Medicine;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE  Our overarching goal is to utilize biology-based mathematical models and advanced molecular imaging to dramatically decrease systemic toxicities while either maintaining or accelerating tumor control in preclinical models of breast cancer. Advances in systemic therapies have improved long-term survival in patients with locally-advanced breast cancer, however there has been a concomitant increase in the associated long- term side effects, including cognitive deficits and cardiotoxicity. We propose to develop the mathematical formalism, and then test this experimentally, that allows for systematically determining regimens that maximize tumor response and minimize side effects (as measured by PET imaging).

PI_NAMEs: SORACE, ANNA C (contact);YANKEELOV, THOMAS E

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: Acceleration;Address;advanced breast cancer;Affect;Aftercare;alternative treatment;Animals;Biological;Biology;Brain;Brain imaging;Breast Cancer Model;cancer therapy;Cardiac;Cardiotoxicity;chemotherapy;clinically relevant;cognitive ability;Cognitive deficits;Combination Drug Therapy;Combined Modality Therapy;Cytotoxic Chemotherapy;Disease;Dose;Dose Limiting;Doxorubicin;ERBB2 gene;glial activation;Goals;Health;Heart;heart function;heart imaging;Histology;Human;Image;imaging modality;Imaging technology;Immunohistochemistry;Immunotherapy;improved;In complete remission;Injury;Long-Term Effects;Malignant Breast Neoplasm;mathematical methods;mathematical model;Mathematics;Measurement;Measures;Membrane Potentials;Methods;Microglia;molecular imaging;mouse model;Neoadjuvant Therapy;neuroinflammation;optimal control theory;optimal treatments;Organ;Outcome;Pathologic;patient derived xenograft model;Patients;Phase I Clinical Trials;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;predictive modeling;prospective test;quantitative imaging;Radiation therapy;Regimen;response;Risk;Schedule;side effect;Site;Standardization;Systemic Therapy;systemic toxicity;targeted treatment;Testing;Therapeutic;Time;Toxic effect;Trastuzumab;Treatment Protocols;treatment strategy;tumor;Tumor Burden;uptake;Xenograft procedure

PROJECT_TITLE: Mathematical modeling and molecular imaging to maximize response while minimizing toxicities from systemic therapies in preclinical models of breast cancer

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE  As organisms age, their cells acquire broad changes in the epigenome, which are alterations around the genome that can impact cellular function. Our project seeks to understand how specific aspects of these epigenomic changes directly influence processes associated with aging. This could establish new methods to address a wide range of aging-related and other disorders.

PI_NAMEs: QI, LEI STANLEY (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Acceleration;Active Sites;Address;Affect;Age;aged;Aging;aging clocks;aging related;Automobile Driving;biological age;Biological Process;Biology;bisulfite sequencing;cell age;Cell Aging;cell behavior;Cell Physiology;cell type;Cells;cellular development;cellular engineering;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Coupled;CRISPR screen;CRISPR/Cas technology;Data;Deposition;Disease;DNA;DNA Methylation;Elements;Engineering;Epigenetic Process;epigenome;epigenomics;Exhibits;Frequencies;Future;Gene Expression;Gene Expression Profile;Gene Silencing;Genome;genome-wide;genomic locus;Genomics;Gold;Guide RNA;Health;high throughput screening;Human;In Vitro;Individual;Inflammation;insight;interest;Libraries;Link;Mesenchymal Stem Cells;Methodology;Methods;Methylation;methylome;Modeling;Modification;Molecular Conformation;Morphology;next generation sequencing;nuclease;Organism;Outcome;Output;Phenotype;Play;Population;Process;Proliferating;Proteins;Publishing;response;RNA library;Role;senescence;senescent cell;Signal Induction;Site;Sorting;Specific qualifier value;standard measure;System;Techniques;Technology;technology platform;Testing;Tissues;tool;transcriptome sequencing;Untranslated RNA;Validation;whole genome;Work;Writing

PROJECT_TITLE: Probing relationships between DNA methylation and cellular senescence with high-throughput CRISPR-based epigenetic editing

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative: Ischemic Heart Disease (IHD) is the number one cause of death worldwide and is worsened by inflammation triggered via therapeutic reperfusion, which remains without medicinal intervention. As neutrophils are the first inflammatory cells recruited to the heart after injury and contribute to infarct expansion, we reasoned that dampening inflammatory activity in these cells would be cardioprotective. Our preliminary results indicate that YES Associated Protein (YAP) positively regulates neutrophil inflammatory function and that suppression of YAP during reperfusion may be a novel therapeutic target for cardioprotective intervention.

PI_NAMEs: FRANCISCO, JAMIE  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Acute;acute stress;Affect;Anti-Inflammatory Agents;Apoptosis;Area;Blood flow;Blood Preservation;Calcium;Cardiac;Cardiac Myocytes;cardiac repair;cardioprotection;Cause of Death;Cells;Cessation of life;Clinical;cofactor;comparison control;Complement;cytokine;Cytoplasmic Granules;Data;Doctor of Philosophy;effective therapy;extracellular;Fibroblasts;Fibrosis;Functional impairment;Gene Expression;Genetic Transcription;Goals;Granulopoiesis;Heart;heart cell;Heart Injuries;Hour;immune cell infiltrate;improved;In Vitro;in vivo;Infarction;Infiltration;Inflammation;Inflammatory;Injury;Intervention;Investigation;Ischemia;ischemic injury;Knockout Mice;Malignant Neoplasms;Medicine;Mentors;Mitochondria;Modeling;Molecular;Mus;Muscle Cells;Myeloid Cells;Myocardial;Myocardial Infarction;Myocardial Ischemia;neutrophil;new therapeutic target;novel;Outcome;Oxidative Stress;Pathologic;Pathway interactions;Patients;Pattern;Phagocytosis;pharmacologic;Physiology;Production;protein activation;protein expression;Protein Inhibition;Proteins;Reactive Oxygen Species;recruit;repaired;Reperfusion Injury;Reperfusion Therapy;Research;response;Role;S100A8 gene;Signal Transduction;Signaling Protein;standard care;Students;Therapeutic;Work

PROJECT_TITLE: The role of neutrophil YAP in cardiac ischemia/reperfusion inflammation and injury


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative By developing a DNA polymerase that can copy and amplify DNA over very long (chromosome-sized) stretches, we will generate a tool for the research community, industry, and medicine that can be used to better create genomes from scratch, and read long stretches of DNA sequence information. The former application will abet the growing field of synthetic biology as it crafts new organisms, while the latter application should foment additional advances in Next Generation DNA sequencing. While there is ample activity in both spheres, the lack of an enzyme that can amplify long stretches of DNA is a hard ceiling that slows further advances.

PI_NAMEs: ELLINGTON, ANDREW D (contact)

PROGRAM_OFFICER_NAME: DARINGER, NICHOLE MARIE

PROJECT_TERMS: Acceleration;Cells;Chimera organism;Chromosomes;Closure by clamp;Collaborations;Communities;design;design and construction;Development;Directed Molecular Evolution;DNA;DNA amplification;DNA Binding Domain;DNA Library;DNA Sequence;DNA sequencing;DNA-Directed DNA Polymerase;Elements;Emulsions;Ensure;Enzymes;Feedback;follow-up;Genes;genetic variant;Genome;Goals;grasp;homologous recombination;improved;In Vitro;Individual;Industry;Kinetics;Length;Libraries;Measures;Medicine;method development;Methods;Mutation;next generation;next generation sequencing;novel;novel sequencing technology;Organism;Polymerase;Polymerase Gene;Process;Production;Property;rational design;Reading;Reagent;Research;Series;single cell sequencing;single molecule;Speed;Stretching;synthetic biology;Technology;Tertiary Protein Structure;tool;Variant;whole genome;Writing;Yeasts

PROJECT_TITLE: Directed evolution of polymerases that can read and write extremely long sequences

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: Reinforcement learning Decision Making (RLDM), which encompasses a range of behaviors critical for survival, is impaired across various psychiatric disorders and symptoms. By acquiring a range of RLDM behavioral data from a large community sample with varying degrees of clinical symptomology, we aim to parse RL behavior into fine-grained mathematically defined constructs and build normative models to make predictions at individual- level. The proposed research aims to study RL behavior disorders at the individual level without parsing the clinical cohort, which could be the first step towards precision medicine by systematically mapping the heterogeneity of psychopathology based on behavior/transdiagnostic symptoms.

PI_NAMEs: KUMAR, POORNIMA  (contact)

PROGRAM_OFFICER_NAME: FERRANTE, MICHELE

PROJECT_TITLE: Building normative models of Reinforcement Learning Decision Making Behavior

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: CITY COLLEGE OF NEW YORK

PHR: NARRATIVE Learning a new skill is thought to enhance the synaptic connection between neurons. Transcranial direct current stimulation can boost the process of synaptic enhancement. This project will establish whether and how this interaction can be used to boost learning of new movement skills, and may thus benefit future treatment strategies for motor rehabilitation.

PI_NAMEs: MARTIN, JOHN H;PARRA, LUCAS C (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Address;Affect;Algorithms;Animal Experimentation;Animal Experiments;Animals;Association Learning;Behavioral;Brain-Derived Neurotrophic Factor;Calibration;Cephalic;Clinical;clinical efficacy;cohort;Consensus;designer receptors exclusively activated by designer drugs;Dose;Double-Blind Method;electric field;Electrical Stimulation of the Brain;Electrodes;Electrophysiology (science);Engineering;Esthesia;experience;experimental study;Fingers;Future;Genetic;Human;Human Experimentation;human subject;In Vitro;in vivo;Inherited;Latino;Learning;Light;Link;Literature;Maps;Measures;Mediating;Membrane;Minority-Serving Institution;Modeling;Molecular;Motor;Motor Cortex;Motor Evoked Potentials;motor learning;motor rehabilitation;Movement;neural;Neurons;neurophysiology;Neurophysiology - biologic function;novel;Outcome;Outcome Measure;Pathway interactions;Physiological;Process;programs;Protocols documentation;Rattus;recruit;repaired;Reporting;Research;response;Rest;Rodent;Sample Size;Scalp structure;sequence learning;Signal Transduction;skills;Specificity;Stroke;Synapses;Synaptic plasticity;Testing;tool;Training;transcranial direct current stimulation;Transcranial magnetic stimulation;Translations;treatment strategy;Underrepresented Populations;Work

PROJECT_TITLE: Interaction of Motor Learning with Transcranial Direct Current - Efficacy and Mechanisms


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;HIV/AIDS;Infectious Diseases;Neurosciences

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Walking impairments and falls are debilitating and common but poorly understood in older persons with HIV (OPWH). This study will examine the effects of brain structure and function and inflammation on walking performance and risk of falling in 240 persons with and without HIV age 50 years and older. This interdisciplinary proposal is designed to improve our understanding of neural and inflammatory mechanisms underlying distinct negative effects of HIV on cognitive control and brain efficiency of locomotion in OPWH and has potential to improve early detection of and direct treatment for mobility impairments and falls in OPWH. the the

PI_NAMEs: HOLTZER, ROEE  (contact);SHARMA, ANJALI

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Acceleration;Address;Adverse effects;adverse outcome;Age;Aging;antiretroviral therapy;Attention;Attenuated;Biological Markers;Brain;brain control;brain magnetic resonance imaging;Cognitive;cognitive control;cognitive performance;Cognitive Therapy;comparison control;design;Disease;Early Diagnosis;Elderly;Exhibits;fall risk;falls;frontal lobe;functional near infrared spectroscopy;Future;Gait;Gait abnormality;Gait speed;Hemoglobin;HIV;HIV/AIDS;human old age (65+);Impaired cognition;improved;Inflammation;Inflammatory;Intervention;Learning;Locomotion;Magnetic Resonance Imaging;Measurement;Measures;Methods;Mobility decline;monocyte;Motivation;multidisciplinary;neural;neuroinflammation;novel marker;older adult;Older Population;Outcome;Outcome Study;Pattern;Persons;Pharmacological Treatment;Prefrontal Cortex;remediation;Reporting;Reproducibility;Resources;Risk;Role;Structure;System;T-Lymphocyte Subsets;Training;Visit;Walking;walking performance;walking speed;Work

PROJECT_TITLE: Central Control and Neuroinflammatory Mechanisms of Locomotion in Older Adults with HIV

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases;Skin Cancer

ORG_DEPT: DERMATOLOGY

PHR: PROJECT NARRATIVE We propose to study a large, multi-institutional cohort of gamma delta T cell lymphomas to identify the biological basis of this disease.

PI_NAMEs: CHOI, JAEHYUK  (contact)

PROGRAM_OFFICER_NAME: DUGLAS TABOR, YVONNE

PROJECT_TERMS: Anatomy;antibody mimetics;Automobile Driving;BCL6 gene;Biological;Biological Markers;Biology;CD4 Positive T Lymphocytes;Cells;Cellular immunotherapy;Clinical;clinical heterogeneity;Clinical Management;clinical phenotype;clinically actionable;cohort;Collection;Cutaneous;Cutaneous Lymphoma;Cutaneous T-cell lymphoma;cytokine;D Cells;Data;Dermal;Dermis;Development;Disease;Disease Management;disease phenotype;disease prognosis;DNA sequencing;effective therapy;Enzymes;Epidermis;Fatty acid glycerol esters;Functional disorder;Future;Gene Mutation;Genes;Genetic;Genetic Markers;Genetic Transcription;Genomics;Goals;Hemophagocytic Lymphohistiocytoses;high dimensionality;Homing;Human;Immunologics;Immunology;Immunophenotyping;Inflammatory;Institution;Interferon Type II;Knowledge;Life;Lymphocyte;Lymphoma;Lymphomagenesis;Malignant Neoplasms;MAP Kinase Gene;Molecular;Molecular Analysis;Morbidity - disease rate;mortality;mutant;Mutation;new therapeutic target;Non-Hodgkin's Lymphoma;novel;Organ;Patients;Pattern;Phenotype;Physiological;Prognosis;receptor;Research;RHOA gene;Sampling;Skin;Skin Cancer;Somatic Cell;Somatic Mutation;Southern Blotting;Stimulus;Syndrome;T-Cell Lymphoma;Testing;therapeutic target;Time;Tissues;transcription factor;transcriptome sequencing;Tumor Burden;Visceral;γδ T cells

PROJECT_TITLE: Mechanisms of Lymphomagenesis of Skin Resident Gamma Delta T cells

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Horizontal gene transfer is one of the main contributors to the worldwide spread of antibiotic resistance, with especially high prevalence in diverse and dense microbial communities, most notably the gut microbiome. This work will provide fundamental, mechanistic insights into the mechanisms underlying the spread of conjugative plasmids encoding antibiotic resistance. These insights have implications for predicting and controlling plasmid fates for medical and biotechnological applications. In particular, this work will significantly contribute to ongoing efforts to develop strategies of antibiotic treatments that efficiently eliminate pathogens with minimized risk of drug resistance spreading.

PI_NAMEs: YOU, LINGCHONG  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Address;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Bacteria;Biology;Biotechnology;Cell division;cell growth;Clinical;Complex;cost;design;DNA biosynthesis;Drug resistance;drug resistant pathogen;effective intervention;Engineering;Enterobacteriaceae;Environment;Environmental Risk Factor;Epidemiology;Escherichia coli;Evolution;Extended spectrum Beta lactamase producing Escherichia coli;Extended-spectrum β-lactamase;fitness;Fostering;Foundations;Gene Expression;Gene Expression Profile;gene product;Gene Transfer;Genes;Genomics;Goals;Growth;gut microbiome;High Prevalence;Horizontal Disease Transmission;Horizontal Gene Transfer;insight;interest;Intervention;Investments;Libraries;Link;Measurement;Measures;Mediating;Medical;Metabolic;microbial community;microbiome;Mobile Genetic Elements;Modernization;Molecular;Nature;next generation sequencing;Parasites;pathogen;pathogenic bacteria;phenomics;Phenotype;Plasmids;Play;Population;Prevalence;prevent;Process;Publishing;Research;Resistance;resistance gene;risk minimization;Role;Study models;synthetic construct;Testing;trait;transcriptomics;transmission process;Vertical Transmission;Work;World Health Organization

PROJECT_TITLE: Tradeoffs between fitness costs and transfer rates in horizontal gene transfer

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences;Prevention;Rare Diseases;Sleep Research

ORG_CITY: IOWA CITY

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: NARRATIVE Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy and thus a major public health problem. Seizures may impair arousal to important stimuli, such as CO2, to contribute to SUDEP. Understanding mechanisms for impairment of CO2-arousal in relevant animal models will importantly inform risk stratification and prophylactic strategies against this devastating disease.

PI_NAMEs: BUCHANAN, GORDON F (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Acute;Animal Model;Animals;Apnea;Arousal;Biological Markers;Carbon Dioxide;Cardiac;Cause of Death;Cell Nucleus;Cessation of life;chemical reduction;Confusion;Conscious;Data;Death Rate;Detection;Disease;dorsal raphe nucleus;dravet syndrome;Electrocardiogram;Electroencephalography;Epilepsy;epileptic encephalopathies;Etiology;experimental study;Fiber;Genetic;Goals;Impairment;Individual;insight;Intervention;Intractable Epilepsy;Life;Link;Measurable;Measurement;Measures;Methods;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Nervous System Disorder;Neurons;novel;optogenetics;Outcome;parabrachial nucleus;Pathway interactions;Patients;Phenotype;Photometry;Pilocarpine;prevent;preventive intervention;prophylactic;Public Health;Publishing;Recovery;Regulation;Research;respiratory;response;Risk;Risk Marker;risk stratification;Role;Seizures;Serotonin;Sleep;societal costs;Status Epilepticus;Stimulus;Stroke;Stupor;Sudden Death;Sudden infant death syndrome;sudden unexpected death in epilepsy;Symptoms;System;Temporal Lobe Epilepsy;Testing;Therapeutic;Wakefulness;Work

PROJECT_TITLE: Serotonergic circuit mechanisms in postictal recovery and arousal

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative This project aims to understand the neural mechanisms by which expectations bias motivated behavior, and how they are overridden when an expectation is incorrect. We focus on the orbitofrontal cortex, which is believed to compute outcome expectations, and use electrocorticography to understand the dominant dynamics in OFC, as well as subregional variation, that produce biasing expectations and update them with new information. Together, this project will provide a uniquely holistic view of OFC function that will advance our understanding of expectation in mental models.

PI_NAMEs: RICH, ERIN L (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TITLE: Mesoscale dynamics underlying expectation bias in the orbitofrontal cortex


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Neurosciences

ORG_CITY: Boulder

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: Project Narrative The huge personal and societal costs of bereavement continue to grow as the US population ages and we face an ongoing pandemic. Using a combination of advanced genetic and cellular approaches, our proposal asks: What are the biological processes that are engaged in the brain when overcoming the loss of a loved one? Answering this question will provide new intervention targets for improving the negative health consequences associated with loss of a loved one and for treating pathological bereavement, such as Prolonged Grief Disorder.

PI_NAMEs: DONALDSON, ZOE REBECCA (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Ablation;Address;Adult;Age;Aggressive behavior;Animal Model;Animals;Atlases;Behavior;Behavior assessment;Behavioral;Bereavement;Biological;biological adaptation to stress;Biological Process;Brain;Cells;daily functioning;Data;diphtheria toxin fragment A;Disease;Distress;Emotional;Exhibits;experience;experimental study;Face;Failure;Future;Gene Activation;Gene Expression;Gene Expression Profile;Genetic;Genetic Transcription;Grief reaction;Health;Human;Immediate-Early Genes;Impaired health;Impairment;improved;In Situ Hybridization;Individual;insight;Intervention;Investigation;loved ones;Maintenance;Maps;Mediating;Mental disorders;Microtus;Modeling;Molecular;neural;Neurons;novel;Nucleus Accumbens;Pain;Pair Bond;pandemic disease;Partner in relationship;Pathologic;Pattern;Persons;Phenotype;Physiological;Play;Population;prairie vole;preference;Process;Proxy;repaired;response;Risk;Rodent Model;Role;selective expression;Series;sex;single-cell RNA sequencing;social;Social Behavior;Social isolation;societal costs;Spouses;Study models;Testing;Therapeutic;therapeutic target;Time

PROJECT_TITLE: The neuromolecular basis of adaptation to bond loss


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: Los Angeles

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Synapses are the primary substrates driving information transfer throughout our nervous system. Defects in synaptic communication are associated with a vast number of neurological, neurodegenerative, and neuropsychiatric diseases including epilepsy, autism, schizophrenia, ALS, and Alzheimer’s Disease. While their importance is undeniable, the mechanisms that establish and modulate the diversity of synaptic strength remain enigmatic. This proposal seeks to reveal fundamental insights into what determines and adaptively modifies the diversity of presynaptic function at glutamatergic synapses in development and plasticity. Ultimately, this knowledge is necessary to understand the etiology of neural diseases resulting from synaptic dysfunction and develop effective therapeutic strategies.

PI_NAMEs: DICKMAN, DION KAI (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Action Potentials;Address;Alzheimer's Disease;autism spectrum disorder;Automobile Driving;Biological Models;botulinum toxin type C;Botulinum Toxins;Calcium;Calibration;Chemosensitization;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;Coupling;Data;Defect;Development;Disease;Drosophila genus;Electrophysiology (science);Epilepsy;Etiology;experience;experimental study;Failure;fly;Functional disorder;Genes;Genetic;Glutamates;Goals;Health;Heterogeneity;Homologous Gene;imaging approach;Individual;innovation;insight;Knowledge;Mammals;Mental disorders;Microscopy;Modeling;Molecular;Molecular Machines;Motor;Motor Neurons;Muscle;Muscle Contraction;Mutagenesis;nanoscale;Nanostructures;Nervous System;Nervous System Disorder;neural;neural circuit;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neuromuscular Junction;Neurons;Neurophysiology - biologic function;neuropsychiatric disorder;neurotransmission;neurotransmitter release;Orthologous Gene;Phase;Positioning Attribute;postsynaptic;presynaptic;prevent;Process;Property;Protein Isoforms;ratiometric;Reagent;Reporter;RNA Splicing;Role;scaffold;Schizophrenia;Site;Structure;superresolution imaging;Synapses;synaptic function;Synaptic plasticity;System;therapeutically effective;Toxic effect;transmission process;ultra high resolution;Vesicle

PROJECT_TITLE: Generating functional diversity from molecular homogeneity at glutamatergic synapses

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Sleep Research

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative In this proposal, we make use of optogenetic and chemogenetic tools, in vivo calcium imaging, RNA-seq, viral-based circuit tracing, and genetic targeting techniques to dissect the neural circuits that control sleep behavior. By identifying novel sleep-inducing neurons in the brain, the work presented in this research proposal will lead to a mechanistic understanding of sleep behavior and may provide valuable information for developing new treatments for various human sleep disorders, such as insomnia.

PI_NAMEs: PENG, YUEQING  (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Adult;Animals;Area;Arousal;awake;Biological Phenomena;Brain;Brain region;Calcium;cell type;circadian;Data;Disease;Electrophysiology (science);experimental study;falls;follow-up;FOS gene;gain of function;Genetic;Genetic Markers;Glutamates;Human;Image;Immunochemistry;in vivo;in vivo calcium imaging;Induced Neurons;innovation;Investigation;Life;loss of function;Maintenance;Maps;Modeling;mouse genetics;Mus;neural;neural circuit;neuronal circuitry;Neurons;neuroregulation;non rapid eye movement;novel;optogenetics;Organism;Output;Pathway interactions;Physiological;Physiology;Pilot Projects;Population;Preoptic Areas;Prevalence;Process;Research;Research Project Grants;Research Proposals;Role;single-cell RNA sequencing;Sleep;sleep behavior;Sleep Disorders;sleep regulation;Sleeplessness;Structure;System;Techniques;Testing;tool;transcriptome sequencing;Transgenic Mice;United States National Institutes of Health;Viral;Wakefulness;Work

PROJECT_TITLE: Neural Control of NREM Sleep in the Medulla

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Infant Mortality;Lung;Neonatal Respiratory Distress;Neurosciences;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Noninvasive Neurally Adjusted Ventilatory Assist (NIV-NAVA) is an FDA approved technology that consistently synchronizes non-invasive respiratory support with infant respiratory drive.  We propose an unblinded, pragmatic, phase III randomized clinical trial in extremely preterm infants 240/7- 276/7 weeks gestational age to determine if NIV-NAVA, compared with non-synchronized nasal intermittent positive pressure ventilation (NIPPV), prevents extubation failure within 5 days (120 hours) of extubation from mechanical ventilation.

PI_NAMEs: COURTNEY, SHERRY ;FOGLIA, ELIZABETH  (contact);KIRPALANI, HARESH

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Age;Air;Alveolar;Birth;Bronchopulmonary Dysplasia;Cessation of life;Chest wall structure;Childhood;Chronic lung disease;Clinical;clinically relevant;Complication;Continuous Positive Airway Pressure;Data;Development;Etiology;Exposure to;extreme prematurity;Extubation failure;Failure;family burden;FDA approved;Gastrointestinal Hemorrhage;gastrointestinal perforation;Gestational Age;Health Care Costs;health care service utilization;Hour;improved;Incidence;Infant;Injury;Intermittent Positive-Pressure Ventilation;Intubation;long-term sequelae;Lung;Mechanical ventilation;Meta-Analysis;Methods;Modeling;Morbidity - disease rate;nCPAP Ventilation;neural;Neurologic;neurotransmission;Nose;novel;Outcome;Oxygen;Pharmaceutical Preparations;Phase;Phase III Clinical Trials;Physiological;Population;premature;Premature Birth;Premature Infant;premature lungs;pressure;prevent;Prevention;randomized, clinical trials;Randomized, Controlled Trials;recruit;respiratory;Respiratory Diaphragm;Respiratory Failure;Role;safety outcomes;Site;Technology;Testing;Tidal Volume;Time;trial design;United States;ventilation;Ventilator;Ventilator-induced lung injury;years of life lost

PROJECT_TITLE: 1/2 The Diaphragmatic Initiated Ventilatory Assist (DIVA) Trial

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(JA)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: ANN ARBOR

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: MI

PHR: Relevance of the Proposed Studies to the VA Patient Care Mission: Age-related Hearing Loss (ARHL) and Age-related Vestibular Dysfunction (ARVD) impact large numbers of Veterans, reducing quality of life, job opportunities and increasing risk for other disorders ranging from falls to dementia. For many Veterans, ARHL and ARVD act on auditory and vestibular systems already impacted by noise exposure during their service. Studies are to develop safe, clinically relevant treatment(s) for ARHL, ARVD and noise-induced acceleration. Studies test mechanism-based interventions that can be started in mid-life and are well positioned for rapid translation to meet the challenges of aging in the Veteran population. Even before pharmacological treatments become clinically available, the knowledge of how noise can accelerate and increase ARHL and ARVD can lead to earlier and better diagnosis and use of available non-pharmacological interventions such as hearing aids for ARHL and physical therapy for ARVD that could increase quality of life and reduce risks for Veterans.

PI_NAMEs: ALTSCHULER, RICHARD  (contact)

PROJECT_TERMS: Acceleration;Affect;Age;Age Months;age related;age related changes;Age Years;age-related disease;Aging;aging related disease;American;Appearance;Auditory system;Award;brain stem auditory evoked potentials;Cells;Cessation of life;Clinical;clinically relevant;Communication;Dementia;Detection;Development;Diagnosis;Diet;disability;Disease;Dizziness;efficacy testing;Elements;equilibration disorder;Equilibrium;Estradiol;Estrogens;Evoked Potentials;Exposure to;extend lifespan;falls;Gait abnormality;Gulf War;Hair Cells;Head;healthspan;Hearing Aids;hearing impairment;Human;human old age (65+);Incidence;Injury;inner ear diseases;Intervention;Knowledge;Life;life span;Measures;Mental Depression;middle age;military veteran;Mission;mouse model;Mus;National Institute on Aging;Noise;noise exposure;Nonpharmacologic Therapy;normal aging;Nursing Homes;Occupations;otoacoustic emission;Patient Care;Persons;Pharmacological Treatment;Physical therapy;Pilot Projects;Positioning Attribute;Presbycusis;prevent;programs;Quality of life;Rattus;Reflex action;Reporting;Response Latencies;Risk;Risk Reduction;Rodent Model;Sensory;Services;Signal Pathway;Sirolimus;Synapses;Testing;Time;Training;Translations;treatment comparison;treatment effect;Vestibular dysfunction;vestibular system;Veterans;young adult;Youth

PROJECT_TITLE: Age Related Hearing Loss and Vestibular Dysfunction

STUDY_SECTION_NAME: Sensory Systems & Communication Disorders[RRD3]


NIH_SPENDING_CATS: Genetics

ORG_CITY: NEW HAVEN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Bacteriophages have profound impacts on microbial communities, ecosystems, and human health, while phage infection initiation is the least understood aspect in phage biology. We combine traditional genetic and molecular biology with cutting-edge imaging techniques to provide novel mechanistic insights into phage adsorption and genome transfer into the host cytoplasm. The proposed in vivo study also has implications on nanotechnology, antibacterial therapeutics, and development of novel DNA translocation systems.

PI_NAMEs: LIU, JUN  (contact);MOLINEUX, IAN J

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Acceleration;Adsorption;Affect;Anti-Bacterial Agents;Bacteriophages;Binding;Biological;Biological Assay;Biology;Capsid;cell envelope;Cell membrane;Cells;Complex;Core Protein;Coupled;Cryo-electron tomography;Cryoelectron Microscopy;Cytoplasm;Development;DNA;DNA-Directed RNA Polymerase;Ecosystem;Evolution;Extravasation;Fiber;flexibility;Gene Deletion;Genes;Genetic;Genetic Materials;Genetic Transcription;Genome;Goals;Grant;Health;Human;Imaging Techniques;In Situ;In Vitro;in vivo;Individual;Infection;insight;Ion Channel;Kinetics;Measures;Mediating;Membrane;microbial community;Molecular;Molecular Biology;Molecular Conformation;Morphogenesis;mutant;nanomachine;Nanotechnology;novel;particle;Penetration;Physiology;Predisposition;Process;promoter;Proteins;recruit;Resolution;Role;Rotation;Signal Transduction;Signal Transduction Pathway;Site;structural biology;Structure;Suppressor Genes;System;Tail;Testing;Therapeutic;viral DNA;Viral Proteins;Virion;Visualization

PROJECT_TITLE: Structural basis of phage infection and DNA ejection

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation;Sleep Research;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Narrative Care partners of persons with traumatic brain injury (TBI) are often faced with considerable physical and emotional stress resulting from their caregiver role; not surprisingly, this stress is associated with negative physical and mental health outcomes for both the care partner and the person for whom they provide care. Given this, interventions focused on improving the health-related quality of life (HRQOL) of these care partners will likely have positive downstream effects for the care recipient. The purpose of this study is to examine the efficacy of a personalized self-management intervention designed to promote care partner self-care; this intervention uses physical activity and sleep data collected using a Fitbit® and real-time self-reports of HRQOL collected via a mobile phone app, to provide care partners with personalized feedback via app alert four times per week.

PI_NAMEs: CARLOZZI, NOELLE E. (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Accelerometer;adaptive intervention;Affect;Anxiety;Beds;Cardiovascular Diseases;care outcomes;care recipients;care systems;Caregiver research;caregiver strain;Caregivers;caregiving;Caring;Charge;Clinical;clinical trial implementation;Clinical Trials Design;Communities;Control Groups;cost;Data;Data Collection;design;Development;Diabetes Mellitus;efficacy evaluation;Emotional Stress;Ensure;Evaluation;Face;Family;Family Caregiver;Fatigue;Feedback;Financial Activity;fitbit;functional outcomes;Funding;Goals;group intervention;Health;health assessment;health management;Health Priorities;health related quality of life;Heart;high dimensionality;Home;Hour;improved;improved outcome;Individual;innovation;insight;Intervention;intervention delivery;Leisure Activities;Life;loved ones;Machine Learning;Measurement;Measures;member;Mental Depression;Mental disorders;Mental Health;mobile sensor;Monitor;multidisciplinary;National Institute of Nursing Research;novel;Nursing Research;Outcome;Outcome Measure;Patient Outcomes Assessments;Patient Self-Report;Personal Satisfaction;Persons;Phenotype;Physical activity;Physical assessment;physical conditioning;Physical Function;poor sleep;Population;post intervention;prevent;Psyche structure;psychologic;Quality of life;Randomized;Randomized, Controlled Trials;Rehabilitation Outcome;Reporting;Request for Applications;Research;Research Priority;Risk;risk prediction;Role;Self Care;Self Management;Sleep;Sleep disturbances;smartphone application;smoking cessation;social;Social Functioning;Social Well-Being;statistics;Stress;Symptoms;System;therapy design;Time;Traumatic Brain Injury;Treatment Efficacy;tv watching;Validation;wearable data;Work;wrist worn device

PROJECT_TITLE: Improving Outcomes for Care Partners of Persons with Traumatic Brain Injury

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Clinical Research;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Hematology;Infectious Diseases;Patient Safety;Sepsis

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: Project Narrative Each year, over 1.5 million people survive sepsis and over one third transition to receive home health care (HHC) services. This study tests the effectiveness of the I-TRANSFER intervention which improves identification and communication of the sepsis survivor to HHC, provides early attention to prevent poor outcomes, and provides guidance on the implementation determinants discovered from a diverse sample of hospitals and home health agencies. The results of the study have the potential to inform clinical guidelines in home health care on a national scale and improve the recovery of the growing population of sepsis survivors.

PI_NAMEs: BOWLES, KATHRYN HELENE (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: Accident and Emergency department;Acute;acute care;Address;Attention;Behavioral Model;Care given by nurses;Caregivers;Caring;Characteristics;Clinical;clinical research site;Code;cohort;Communication;Communities;comparative effectiveness study;comparison intervention;Consolidated Framework for Implementation Research;cost;Data;Data Set;Data Sources;design;Diagnosis;Discipline of Nursing;Effectiveness;effectiveness testing;Emergency department visit;Equilibrium;Evaluation;experience;follow-up;Goals;Guidelines;Health;Health Care Costs;health care service;Health Personnel;Health Professional;Health Services;Healthcare;Healthcare Industry;Heart failure;Home;Home Care Services;Home Health Agency;hospital care;hospital readmission;Hospitalization;Hospitals;Hybrids;implementation barriers;implementation determinants;implementation science;improved;improved outcome;Industry;Infection;innovation;Inpatients;insight;Intervention;Knowledge;Length of Stay;Medical;Medicare;Medicare claim;Medication Management;Medicine;Modeling;Monitor;Morbidity - disease rate;mortality;Myocardial Infarction;Nurses;Outcome;Outpatients;Patients;Persons;Pneumonia;Population;prevent;Process;Professional Organizations;Protocols documentation;Provider;Publishing;Qualitative Methods;Randomized;randomized trial;readmission rates;Recovery;Registered nurse;Research Personnel;Sampling;Science;Sepsis;Site;skills;Survivors;Talents;Testing;Time;treatment as usual;United States;Visit;Visiting Nurse;Vulnerable Populations;Work

PROJECT_TITLE: I-TRANSFER Improving TRansitions ANd outcomeS oF sEpsis suRvivors

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]


ADMINISTERING_IC: AT

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Complementary and Integrative Health;Natural Products

ORG_CITY: CORVALLIS

ORG_DEPT: MISCELLANEOUS

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative The majority of drugs and supplements in use today are derived from natural products. This training grant will support the doctoral education of the next generation of scientists who will be responsible for establishing the safety and efficacy of dietary supplements and for the discovery of new therapeutic agents from natural product sources.

PI_NAMEs: MAHMUD, TAIFO ;VAN BREEMEN, RICHARD B (contact)

PROGRAM_OFFICER_NAME: BAUMGARTNER, JENNIFER NICOLE

PROJECT_TERMS: Complementary Health;Integrative Medicine;Natural Products;Research Training

PROJECT_TITLE: Research Training in Natural Product Complementary and Integrative Health


ORG_CITY: MIAMI

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative The presence of calcium mineral in the arterial wall severely disrupts vascular function and predicts survivability in patients with chronic kidney disease. This study seeks to establish the nanoscale mechanisms that initiate this mineral formation and develop therapeutic strategies to target this process.

PI_NAMEs: HUTCHESON, JOSHUA D (contact)

PROGRAM_OFFICER_NAME: FLEG, JEROME L

PROJECT_TERMS: 3-Dimensional;Adenine;Affect;Age;Back;Biological Assay;Blood Vessels;calcification;Calcinosis;Calcium;Cardiovascular system;Caveolae;caveolin 1;Cell membrane;Cells;Charge;Chronic Kidney Failure;Clinical;clinically relevant;Data;Dependence;Diet;disease model;effective therapy;efficacy testing;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Evolution;extracellular vesicles;Heart;high risk population;Hydrogels;improved;In Vitro;in vivo;in vivo Model;Individual;inorganic phosphate;Ions;Malignant Neoplasms;Measures;Mechanics;Medial;Mediator;Methods;mineralization;Minerals;Morbidity - disease rate;mouse model;Mus;nanoparticle;nanoscale;novel;Outcome;Patients;Post-Translational Protein Processing;prevent;Process;Property;Publishing;Receptor Inhibition;Reporting;Role;Safety;small molecule;Smooth Muscle Myocytes;Survival Rate;Tamoxifen;Techniques;Testing;Therapeutic;therapeutic development;Therapeutic Effect;therapeutic evaluation;therapeutic target;Time;trafficking;Vascular calcification;Vascular Smooth Muscle;Vesicle

PROJECT_TITLE: Targeting the Caveolae-Dependent Mechanism of Calcifying Extracellular Vesicle Formation

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ORG_DEPT: BIOCHEMISTRY

PHR: Project Narrative A burgeoning hypothesis in Parkinson’s disease (PD) research is that PD begins in the gut, resulting in the subsequent alpha-synuclein (? S) aggregation and neurodegeneration. Furthermore, gut permeability, which enables leakage of microbial ligands from the gut microbiota into host tissues, and innate immune receptors, which recognize these ligands are widely associated with PD, although whether these factors directly initiate or exacerbate PD is unclear. In this proposal, I will investigate 1) the connections among microbial leakage, gut leakiness, and PD; 2) the role of innate immune receptors in PD pathogenesis; and 3) perform unbiased, genetic screens to identify novel host and bacterial PD factors, collectively increasing our understanding of PD initiation and progression and identification of novel therapeutic targets.

PI_NAMEs: REDWEIK, GRAHAM  (contact)

PROGRAM_OFFICER_NAME: KOEMETER-COX, ANDREW IAN

PROJECT_TERMS: Affect;alpha synuclein;American;Animal Diseases;Animals;Anti-Inflammatory Agents;Attenuated;Bacteria;Bacterial Genes;basolateral membrane;Bifidobacterium;Biology;Brain;Caenorhabditis elegans;Characteristics;Chemicals;Chromosome Mapping;Cloning;Complex;Confocal Microscopy;cost;cost efficient;CRISPR/Cas technology;Deletion Mutation;Diagnosis;Disease;disease diagnosis;disease model;Disease Outcome;disease phenotype;Disease Progression;DNA;DNA Sequence Alteration;dopaminergic neuron;effective therapy;empowerment;Enhancers;Enteral;Epithelium;Escherichia coli;Extravasation;Food;Functional disorder;Genes;Genetic;Genetic Screening;genome editing;Gnotobiotic;Goals;gut bacteria;gut microbes;gut microbiota;Homologous Gene;host-microbe interactions;Human;Immune;Immune signaling;Immunologic Receptors;Immunology;improved;in vivo;in vivo Model;Individual;Inflammation;Inflammatory;Inflammatory Response;innate immune sensing;insight;Integration Host Factors;Intestinal permeability;Intestines;Label;Lactobacillus;Lead;Leaky Gut;Ligands;Lipopolysaccharides;Liquid substance;Longevity;loss of function;Mammals;Measures;Mediating;Microbe;microbial;Microbiology;model organism;Modeling;Molecular;Monitor;motor control;Movement;Mus;Mutagenesis;mutant;Mutate;Mutation;Natural Immunity;Nature;Nematoda;Nerve Degeneration;Neurobiology;Neurodegenerative Disorders;neuroinflammation;neuron loss;new therapeutic target;novel;Parkinson Disease;Pathogenesis;Pathology;Patients;Pattern;Pattern Recognition;Prokaryotic Cells;Proteins;Receptor Activation;Research;Role;Route;Saline;screening;Screening procedure;Signal Transduction;Source;Symptoms;Techniques;Therapeutic Uses;Tight Junctions;Tissues;Toll-like receptors;Vagus nerve structure

PROJECT_TITLE: Parkinson's and Prokaryotes: roles of bacteria, gut permeability, innate immunity, and genetics in C. elegans dopaminergic neurodegeneration

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE The brain plays an integral role in the genesis of eating behaviors. However, the brain’s contribution to dysregulated eating behavior is not well understood during sensitive developmental periods such as adolescence, when excessive weight gain and obesity prevalence are a significant concern. In the proposed study, we will examine how the brain’s response to excess energy is related to dysregulated eating behaviors in adolescents with and without obesity with the overarching goal of providing a scientific basis to build new models of adolescent obesity risk and to test novel interventions for dysregulated eating behavior and obesity in developmentally vulnerable pediatric populations.

PI_NAMEs: SHAPIRO, ALLISON LIVIA BUTI (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Address;Adolescence;Adolescent;Adolescent obesity;Adult;Amygdaloid structure;Animals;Anterior;Appetite Regulation;Award;Behavior;Biometry;Brain;Brain imaging;Brain region;career;career development;Characteristics;Child;Childhood;cingulate cortex;Colorado;Communication;Consumption;Cues;Data;Dedications;design;Desire for food;Development;Development Plans;developmental psychobiology;Disinhibition;Down-Regulation;Eating;Eating Behavior;eating in absence of hunger;Emotional;Energy consumption;Energy Intake;Environment;Epidemiology;Equipment;Etiology;excessive weight gain;Faculty;Food;Foundations;Functional Magnetic Resonance Imaging;Funding;Glucose;Goals;Health;Hyperphagia;Hypothalamic structure;imaging facilities;improved;Individual;Inferior;innovation;Insula of Reil;interest;Intervention;Laboratories;life span;Link;Magnetic Resonance Imaging;Master of Public Health;Measurement;Measures;Medical;Mentored Research Scientist Development Award;Mentors;Methodology;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of Mental Health;neural;Neurobiology;neuroimaging;Neurons;Neuropeptide Receptor;novel;Nucleus Accumbens;Obesity;obesity development;obesity prevention;obesity risk;obesity treatment;overexpression;Pennsylvania;Play;Population;Positioning Attribute;Postdoctoral Fellow;Prevalence;Process;programs;Protocols documentation;Psychiatry;Psychopathology;Publications;Questionnaires;Research;Research Support;Resources;response;Rest;Rewards;Role;Satiation;Scientist;Signal Transduction;Stimulus;Sweetening Agents;System;Taste Perception;Testing;theories;Time;Training;United States;Universities;Weight Gain;Youth

PROJECT_TITLE: The neural underpinnings of disinhibited eating behavior in adolescents with and without obesity

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]