NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Congenital Heart Disease;Congenital Structural Anomalies;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Rare Diseases;Rural Health;Social Determinants of Health

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE As a Core Clinical Research Center for >20 years, Pediatric Heart Network (PHN) Utah has supported the mission to improve outcomes for individuals with congenital heart disease and pediatric acquired heart disease, and made particularly exceptional contributions to scientific discoveries, administrative activities, and training the next generation of researchers. Going forward, PHN Utah will bring participants from unique underrepresented groups as well as additional resources and expertise to address inequities in all aspects of research with the infrastructure and experience to lead a big data approach to collecting clinical, genomic, and social determinants of health data to empower equitable personalized outcome prediction. Based on its history of excellence, well defined leadership transition plan, and unique research infrastructure, PHN Utah is ideally poised to seamlessly move into the next cycle and increase their considerable contributions as a Clinical Research Center.

PI_NAMEs: CABRERA, ANTONIO ;TRUONG, DONGNGAN ;WILLIAMS, RICHARD VINCENT (contact)

PROJECT_TERMS: Address;Advocacy;Affect;Alaska Native;Ancillary Study;Artificial Intelligence;Artificial Intelligence platform;atrioventricular septal defect;Award;Big Data;Bioinformatics;care delivery;Caring;Childhood;Clinical;clinical care;Clinical Data;Clinical Research;Collaborations;Communities;Complex;congenital heart abnormality;Data;data resource;Data Science;design;Disease Outcome;diversity and equity;Electronic Health Record;Eligibility Determination;empowerment;Environment;Equity;equity, diversity, and inclusion;Ethics;ethnic minority;Ethnic Origin;experience;explainable artificial intelligence;Exposure to;Family;Fostering;Foundations;frontier;Funding;genomic data;Genomics;Genotype;Goals;Grant;Growth;Health;health care availability;health care disparity;health data;Heart;Heart Diseases;Heterogeneity;Hour;improved;improved outcome;Individual;Inequity;Infrastructure;innovation;insight;Institution;Interdisciplinary Study;International;Internships;Investments;Knowledge;Leadership;Lesion;member;Mentors;Mentorship;Mission;Multicenter Studies;Music;National Heart, Lung, and Blood Institute;Native Americans;Native Hawaiian or Other Pacific Islander;next generation;Outcome;outcome prediction;Outcomes Research;Oxandrolone;Participant;participant retention;Patients;Pediatric Cardiac Genomics Consortium;Pediatric cardiology;Pediatric Hospitals;Perception;Performance;personalized medicine;Phenotype;Physicians;Population;Positioning Attribute;precision medicine;Productivity;programs;Publications;Quality of life;Race;racial minority;Readability;Recording of previous events;recruit;Research;Research Design;Research Infrastructure;Research Personnel;Resources;Role;Rural;Rural Population;rural underserved;Scholarship;Science;Scientist;Site;skills;social health determinants;success;Testing;tool;Training;Underrepresented Populations;Universities;Utah;Vision;web platform;Work;Writing

PROJECT_TITLE: Pediatric Heart Network (PHN) - Utah Center


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: STANFORD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE This project uses cell-free Xenopus egg extracts to investigate how the spatial organization of the cytoplasm arises, and how the crowding and organization of the cytoplasm affects the basic biochemistry of life. Our experimental approaches are underpinned by theory and computation. Our hope is that the principles that underpin spatial organization and biochemical regulation in this one particular highly manipulable system will shed light on many others.

PI_NAMEs: FERRELL, JAMES E. (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Action Potentials;Affect;Apoptotic;Biochemical;Biochemistry;Biological;blastocyst;Calcium Oscillations;Cell Cycle;Cell Physiology;Cells;Chemicals;Complex;Crowding;Cytoplasm;Differential Equation;DNA biosynthesis;egg;Enzymes;experimental study;Five-Year Plans;Genetic Transcription;Homeostasis;Hour;In Vitro;inhibitor;insight;Interphase;Life;mathematical model;Mitosis;Mitotic;Modeling;Natural regeneration;Production;reconstitution;Regulation;self organization;Speed;System;Testing;theories;Xenopus

PROJECT_TITLE: Cytoplasmic organization and systems-level function in Xenopus extracts

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Pediatric;Social Determinants of Health

ORG_CITY: CHARLESTON

ORG_DEPT: PEDIATRICS

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE The Pediatric Heart Network has established best practices for multi-center research in congenital and acquired pediatric heart disease. Collaboration among the Clinical Research Centers, the Data Coordinating Center and other stakeholders permits multi-center evaluation of medical, interventional, and surgical therapies; provides a training platform for fellows, junior faculty, and nurses; supports development of novel techniques and methodologies; and promotes dissemination of study results to improve the scientific basis for the care of affected individuals. In MUSC’s application to continue participation as a core PHN site, we provide compelling evidence of local expertise, a sustained track record of successful multicenter clinical investigation and development of junior investigators and propose a ground-breaking study in neonates undergoing cardiac surgery to examine the impact of environmental exposures on clinical outcomes and associated disparities.

PI_NAMEs: ATZ, ANDREW M (contact);COSTELLO, JOHN M;GRAHAM, ERIC M.

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: Adult;Affect;African American;Area;Arrhythmia;Cardiac;Cardiac Catheterization Procedures;cardiac muscle disease;Cardiac Surgery procedures;Cardiovascular system;career;Caring;Characteristics;Child;Childhood;Clinical;clinical development;clinical investigation;Clinical Investigator;Clinical Research;Clinical Research Protocols;clinical research site;Clinical Trials;Collaborations;congenital heart abnormality;Country;Cyclohexanones;Data;Data Coordinating Center;data registry;Databases;Dedications;Development;Disparity;Elements;Enrollment;Ensure;Environment;Environmental Exposure;Environmental Impact;ethnic diversity;Ethnic Origin;Evaluation;experience;Exposure to;Extramural Activities;Faculty;Funding;Future;Goals;Grant;Heart;Heart Diseases;Home environment;Hospitals;Household;Human Resources;improved;Individual;Industry;Inflammatory;Information Dissemination;Infrastructure;Intervention;Journals;Learning;Low income;Medical;Mentors;Methodology;Multi-Institutional Clinical Trial;Multi-site clinical study;Multicenter Studies;neonate;Neurotoxins;next generation;North America;novel;Nurse Practitioners;Nurses;Operative Surgical Procedures;Outcome;outcome disparities;Participant;participant retention;Patient Care;patient population;Patient-Focused Outcomes;Patients;pediatric cardiologist;Pediatric cardiology;Pediatric Research;phthalates;Play;Population;Population Heterogeneity;programs;Publications;Race;racial diversity;randomized, clinical trials;Recording of previous events;recruit;Registries;Research;Research Activity;Research Infrastructure;Research Personnel;Resources;Role;rural area;Site;skills;Socioeconomic Status;South Carolina;success;Supervision;Techniques;Time;Training;United States;United States National Institutes of Health;Universities;volatile organic compound;Work

PROJECT_TITLE: Pediatric Heart Network: Medical University of South Carolina

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-Q (O2)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Cells in epithelial tissues are connected by cell-cell junctions that sense mechanical forces and respond by activating signaling pathways, recruiting mechanosensitive proteins, and remodeling their connections to the cytoskeleton. Disruption of cell-cell junctions contributes to cancer cell metastasis and barrier function diseases such as inflammatory bowel disease. The proposed research will strengthen our understanding of how epithelial cells sense and respond to physiological forces to maintain, reinforce, and remodel their cell-cell junctions; therefore, this research will help us better understand the pathogenesis of cancer and barrier function diseases and potentially identify new targets for treating these diseases.

PI_NAMEs: MILLER, ANN LOUISE (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Actins;Actomyosin;Adherens Junction;Adhesions;Apical;Architecture;Biological Assay;Calcium;cancer cell;Cell-Cell Adhesion;Cells;Cytokinesis;Cytoskeleton;Disease;Embryo;Ensure;Environment;Epithelial Cells;Epithelium;Flare;flexibility;Goals;Image;Inflammatory Bowel Diseases;innovation;Intercellular Junctions;Maintenance;Malignant Neoplasms;mechanical force;Mechanics;Mediating;Microscopy;Modeling;Molecular;Morphogenesis;Neoplasm Metastasis;novel;Organism;Pathogenesis;Physiological;Proteins;Psychological reinforcement;recruit;repaired;Research;response;rho;rho GTP-Binding Proteins;rho GTPase-activating protein;Scaffolding Protein;Shapes;Signal Pathway;Signal Transduction;Signaling Protein;Tight Junctions;Tissues;tool;transmission process;Work;Xenopus laevis

PROJECT_TITLE: Epithelial cell-cell junction remodeling in response to cell- and tissue-scale forces

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


NIH_SPENDING_CATS: Cancer

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: NARRATIVE Alterations of metal homeostasis are characteristic of multiple pathologies, including neurodegeneration and cancer. A reprogrammed iron metabolism is a key descriptor of malignant cells, which maintain increased iron acquisition and retention. With the long-term goal of improving the current understanding of iron dysregulation in human disease and its potential impact on cancer treatment, this research program focuses on the synthesis and biological evaluation of a new generation of selective molecular tools for intracellular iron binding.

PI_NAMEs: TOMAT, ELISA  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: anti-cancer research;Behavior;Binding;Biological;Biology;cancer cell;cancer therapy;Cations;Cell Cycle;Cell Death;Cells;cellular targeting;Characteristics;Chelating Agents;chelation;Chemicals;Chemistry;Clinical;Complex;Copper;design;Disease;disulfide bond;Engineering;Evaluation;Generations;Goals;Homeostasis;Human;human disease;Image;improved;Iron;Iron Chelating Agents;Iron Chelation;iron metabolism;Malignant - descriptor;Malignant Neoplasms;Metals;Methods;Molecular;Nerve Degeneration;Normal Cell;Nutrient;overexpression;Oxidation-Reduction;Pathologic;Pathology;Pharmacologic Substance;Phenotype;Physiological;Physiology;programs;Proliferating;Proteins;Reaction;Reactive Oxygen Species;Research;Role;Signal Transduction;Sulfhydryl Compounds;System;Tetrazolium;Therapeutic;tool;Transition Elements;tumor progression;uptake

PROJECT_TITLE: Coordination chemistry approaches to target cellular metal dysregulation

STUDY_SECTION: MRAE

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - E Study Section[MRAE]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Bacteriophages are the most numerous organisms in the biosphere and profoundly influence microbial diversity, bacterial pathogenesis, and biotechnological advances. Dynamic bacteriophage-bacterium interactions contribute to narrow patterns of host specificity by phages, driven by bacterially encoded defense systems, prophage-mediated defense systems, and plasmids. Elucidating these systems and their roles in phage host range will advance our understanding of microbial dynamics and fuel the development of phage-based therapeutics.

PI_NAMEs: HATFULL, GRAHAM F. (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Actinobacteria class;Antibiotic Resistance;Antibiotics;antimicrobial;Area;Attention;Bacteria;Bacterial Infections;Bacteriophages;Biological;Biology;Biotechnology;Cell Death;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Cystic Fibrosis;Development;Disease;DNA Restriction-Modification Enzymes;Elements;Evolution;Genes;Genetic;Genome;genomic profiles;Genus Mycobacterium;Immune System Diseases;Individual;Infection;insight;Lytic Phase;Mediating;microbial;Modification;Mycobacterium abscessus;non-tuberculosis mycobacteria;novel;opportunistic pathogen;Organism;pathogen;Pathogenesis;Pattern;Persons;Plasmids;Play;Population;preference;Prophages;Reporting;Resistance;Resources;Role;Shapes;Specificity;Swelling;System;Therapeutic;Therapeutic Uses;Variant;Virus

PROJECT_TITLE: Bacteriophage diversity, dynamics, function, and exploitation

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Genetics;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

PHR: PROJECT NARRATIVE Cis regulatory elements (CREs), including enhancers and promoters, are required to drive cell-type specific gene expression and are therefore elegantly regulated by various chromatin associated proteins. We propose to uncover the biological roles and interplay of chromatin regulatory complexes and non-protein-coding RNAs (ncRNAs) within embryonic stem (ES) cells and during differentiation, focusing on those ncRNAs generated at both gene proximal and distal CREs. Together, these studies will uncover the mechanisms and wiring of gene regulatory networks responsible for directing cell fate.

PI_NAMEs: HAINER, SARAH JANE (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Binding;Biological;Cell Differentiation process;Cell Physiology;cell type;Cells;Chromatin;Chromatin Structure;Code;Compensation;Complex;Development;developmental disease;Disease;Distal;embryonic stem cell;Enhancers;Epigenetic Process;Gene Expression;Gene Expression Profile;gene regulatory network;Genes;Genetic Transcription;genome-wide;Goals;Histones;interest;Laboratories;Mediating;Molecular;Molecular Chaperones;Mutate;neural;Nucleosomes;promoter;Property;Proteins;Regulation;Regulatory Element;Research;RNA;Role;self-renewal;Somatotype;Specific qualifier value;stem cells;Systems Biology;targeted treatment;transcription factor;Transcriptional Regulation;Untranslated RNA;Work

PROJECT_TITLE: Chromatin-mediated mechanisms of transcription regulation in ES cells


NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Antibiotic resistance and evasion of treatment are increasing at alarming rates for numerous important bacterial pathogens and represent a serious threat to human health. This basic-science grant uses the “superbug” Streptococcus pneumoniae as a highly tractable model to understand the dynamics and regulation of peptidoglycan cell wall synthesis in ovoid-shaped bacteria. New findings from this grant about the mechanisms and components of peptidoglycan synthesis have the potential to provide new targets and reveal vulnerabilities for future antibiotic and vaccine discovery.

PI_NAMEs: WINKLER, MALCOLM E. (contact)

PROJECT_TERMS: Address;Antibiotic Resistance;Antibiotics;Bacteria;Basic Science;Biological Assay;capsule;Cell Wall;Cells;Extracellular Protein;Future;Gram-Positive Bacteria;Grant;Health;Human;Hydrolase;Hydrolysis;innovation;Knowledge;Link;Microscopy;Modeling;Motion;Muramidase;Mutation;nanomachine;Nodal;Osmotic Shocks;pathogenic bacteria;Pathway interactions;Peptidoglycan;Peripheral;Regulation;Resolution;respiratory pathogen;Rod;Role;scaffold;Second Messenger Systems;Shapes;single molecule;Streptococcus pneumoniae;Stress;Superbug;Teichoic Acids;Thick;treadmill;vaccine development;vaccine discovery

PROJECT_TITLE: Dynamics and Regulation of Peptidoglycan Cell Wall Synthesis in the Superbug Streptococcus pneumoniae


PHR: Membrane proteins face substantial hurdles as they fold and assemble in the endoplasmic reticulum (ER), but a dedicated quality control pathway known as ER associated degradation (ERAD) selects and destroys misfolded membrane proteins. Yet, how misfolded integral membrane ERAD substrates are prevented from trafficking beyond the ER in human cells, and how toxic aggregation-prone membrane proteins are destroyed are poorly understood. These knowledge gaps will be addressed by applying innovative tools, developing new models, and working with resident experts. In addition, most ERAD substrates were discovered in a nonsystematic manner; therefore, another objective is to apply a new computational-experimental pipeline to uncover previously uncharacterized amino acid variants that destabilize two ion channels, thus leading to the identification of “new” disease-associated ERAD substrates.

PI_NAMEs: BRODSKY, JEFFREY L. (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: 26S proteasome;Address;Alleles;Amino Acids;Biological Models;Cells;Cellular biology;Charge;Chemicals;Collaborations;Communities;Cytoplasm;Cytosol;Dedications;Degradation Pathway;Disease;Endoplasmic Reticulum;Environment;Etiology;Face;Generations;Genes;Goals;Heart;Human;hydrophilicity;Individual;Inherited;innovation;Integral Membrane Protein;Ion Channel;Ion Transport;Knowledge;Link;loss of function;Membrane;Membrane Proteins;Methods;misfolded protein;Modeling;Molecular;mutant;Mutation;Names;non-Native;novel;Pathway interactions;personalized medicine;posters;prevent;Protein Biosynthesis;protein folding;protein transport;Quality Control;reconstitution;Research;Side;solute;Techniques;tool;Toxic effect;trafficking;Translating;Transmembrane Domain;Ubiquitination;Variant

PROJECT_TITLE: ER and post-ER quality control of integral membrane proteins


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: YORKTOWN HEIGHTS

ORG_NAME: IBM THOMAS J. WATSON RESEARCH CENTER

ORG_STATE: NY

PHR: Project Narrative-Relevance The concepts and tools developed in the quantitative modeling of different biological complex with mutliple subunits will be useful in understanding functions and dynamics of other biological complexes in all living systems, including human. The molecular level understanding of signal transduction and motor functions in large protein complexes is important to study the mechanisms of signaling and transport processes that are critical for human health.

PI_NAMEs: TU, YUHAI  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TITLE: Deciphering structure-function relationship in large protein complexes by modeling

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD)

ORG_DEPT: CHEMISTRY

PHR: Relevance The goal of this research effort is to develop novel and versatile methods to study via computer simulation biological molecules and their interactions with specific focus on methods for small molecule (drug-like) interactions with their biological receptors and pH-dependent mediation of biomedically important processes. Using a multidisciplinary approach, improvements in theory and methods will be tested through strategic biomedical applications with experimental collaborators and new insights into fundamental biomedical questions relating transcription, cancer and signaling will be addressed.

PI_NAMEs: BROOKS, CHARLES L (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Acids;Actin-Binding Protein;Address;Allosteric Site;Area;Big Data;Biological;Biomedical Research;Chemicals;Collaborations;Communities;Complex;Computer Simulation;Computer software;Computing Methodologies;CREBBP gene;design;Development;Docking;Enzymes;Equilibrium;Evolution;Fibroblast Growth Factor;Flavins;Free Energy;Genetic Transcription;Goals;improved;innovation;insight;interdisciplinary approach;Interleukins;Ligand Binding;Ligands;Malignant Neoplasms;MED25 gene;Mediating;Mediation;Methodology;Methods;Mixed Function Oxygenases;Modeling;models and simulation;Molecular;Molecular Conformation;molecular dynamics;myristoylation;novel;Nucleic Acids;Pharmaceutical Preparations;Pharmacologic Substance;Phosphotransferases;Play;Process;Proteins;Protocols documentation;protonation;receptor;Research;Role;Sampling;Signal Transduction;simulation;small molecule;software development;software infrastructure;Statistical Mechanics;Statistical Methods;Structure;Technology;Testing;theories;Thermodynamics;tool;Transcriptional Activation;Work

PROJECT_TITLE: Theory and Modeling of Biomolecules and their Interactions


NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PORTLAND

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Heart disease is the leading cause of mortality among Yup'ik men and the second most common cause of death among Yup'ik women. This study will design and evaluate a culturally grounded, multi-level intervention focused on increasing intake of traditional foods and healthy market foods, decreasing intake of processed foods and increasing physical activity to reduce heart disease risk among Yupik adults. If successful, the intervention can be disseminated to other Yup'ik communities.

PI_NAMEs: BOYER, BERT BRANDON (contact);GITTELSOHN, JOEL

PROGRAM_OFFICER_NAME: PUGGAL, MONA A

PROJECT_TERMS: Accelerometer;active lifestyle;adiponectin;Adult;Alaska Native;Alaska Native population;Behavioral;Berry;Beverages;Biological Markers;blood pressure reduction;Body Weight;Carbon Isotopes;Cardiac health;Cardiometabolic Disease;cardioprotection;Cause of Death;Communities;community based participatory research;community engagement process;Community Health Education;community intervention;community led intervention;community partners;community planning;community research;Consumption;Cross-Sectional Studies;Dancing;design;Diet;dietary;Dietary Practices;disorder risk;Dose;Educational workshop;effectiveness evaluation;Environment;Event;experience;Facebook;Festival;Fishes;Food;Food Access;food environment;food marketing;Foundations;Frequencies;Goals;good diet;Grain;Harvest;Health;Health Benefit;health disparity;Health Food;Heart;heart disease risk;Heart Diseases;Home;implementation evaluation;implementation facilitators;Improve Access;improved;Indigenous;Individual;Intake;Intervention;Intervention Studies;Knowledge;Life;Link;Lipids;Malignant Neoplasms;Mammals;marine;Measures;member;men;Metabolic syndrome;Methods;Modeling;mortality;multi-component intervention;Native American community;Nitrogen Isotopes;Outcome;Participant;Persons;Physical activity;Plants;post intervention;Postdoctoral Fellow;primary outcome;Process;process evaluation;Production;programs;protective factors;psychosocial;Questionnaires;Race;Randomized;Research;Research Training;response;Risk;Risk Factors;Risk Reduction;Sales;satisfaction;saturated fat;Schools;secondary outcome;sedentary lifestyle;Self Efficacy;Shapes;social;social cognitive theory;Sodium;Sports;stable isotope;sugar;System;systemic inflammatory response;Testing;Text Messaging;Time;Tribes;Trust;Visual;Vitamin D;wild bird;Woman;Yup'ik

PROJECT_TITLE: A community-led intervention (DAiLY) promoting a heart-healthy diet and active lifestyle: The Yup'ik way

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-P (55)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Complementary and Integrative Health;Natural Products

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative Our research program continues in the tradition of exploring the enzymes and pathways of secondary metabolism and natural product biosynthesis for novel chemistry that may be of value for the betterment of human health and well-being. A particular emphasis is placed on the detailed mechanisms and evolution of radical-mediated chemical reactions leading to structurally unique antiviral (oxetanocin A and albucidin), antifungal (blasticidin S) and antihelminthic agents (hikizimycin) as well as the biosynthesis of high energy (ladderane) and antibacterial agents (oxazinomycin and albomycin). By investigating these and similar systems, we aim to establish the fundamental chemical principles by which these reactions occur and in particular how highly reactive radical intermediates are guided towards biochemically useful compounds.

PI_NAMEs: LIU, HUNG-WEN  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TITLE: Novel Mechanisms of Catalysis in Natural Product Biosynthesis


ORG_CITY: SEATTLE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative The proper three-dimensional organization of DNA within the nucleus is critically important for healthy cells, and alterations to organization are associated with developmental disease and cancer. This research program aims to better characterize the patterns of DNA organization that occur in healthy cells and to investigate how these impact important cellular processes such as gene expression, DNA replication, and DNA repair. A more complete understanding of how 3D genome organization functions within the cell will provide key insights into why this process is associated with human disease and may inform new therapeutic strategies.

PI_NAMEs: BELIVEAU, BRIAN JOSEPH (contact)

PROGRAM_OFFICER_NAME: GAILLARD, SHAWN R

PROJECT_TERMS: 3-Dimensional;Address;Architecture;Bioinformatics;biophysical properties;Biophysics;cell fixing;Cell Nucleus;Cell Physiology;Cells;cellular imaging;Chromosome Mapping;Chromosome Structures;Chromosomes;Complex;cost;Data Set;design;Development;developmental disease;Diameter;DNA;DNA biosynthesis;DNA Repair;Environment;Fluorescent in Situ Hybridization;Frequencies;Gene Expression;Genetic Transcription;Genome;genome-wide;Genomics;Hi-C;human disease;Imaging technology;Individual;insight;live cell imaging;Malignant Neoplasms;Mammalian Cell;meter;Methods;Microscopy;nanoscale;novel therapeutic intervention;Nuclear;Oligonucleotide Probes;Optics;Pattern;physical property;Population;Process;programs;Proteins;repaired;Research;Resources;Sampling;screening;Signal Transduction;single molecule;Structure;superresolution microscopy;Techniques;Technology;Tissues;Trans-Activators;Visual;Work

PROJECT_TITLE: Probing the dynamics of chromosome organization in single cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ADMINISTERING_IC: TR

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Emergency Care;Health Services

ORG_CITY: HOUSTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: : The K12 program at The University of Texas Health Science Center at Houston is a highly innovative program focused on training Scholars to use the most rigorous feasible study designs to address important health challenges and improve overall public health. Effective strategies include implementing deep quantitative training with emphasis on Bayesian reasoning, de-emphasizing dichotomous (significant vs. not significant) thinking, and providing directly interpretable probabilistic frameworks that improve clinical decision-making. The program’s emphasis on mentorship has produced 43 major grants and developed 44 academic leaders among K alumni since 2006.

PI_NAMEs: MILLER, CHARLES C (contact);TYSON, JON E.

PROGRAM_OFFICER_NAME: MERCHANT, CAROL

PROJECT_TERMS: Acceleration;Achievement;Age;Bayesian Method;Beds;biomedical informatics;Cancer Center;career development;Child;Clinical;clinical care;Clinical Investigator;Clinical Research;Clinical Sciences;Clinical Skills;Clinical Trials;community engagement;comparative effectiveness;Comparative Effectiveness Research;Competence;cost;COVID-19 pandemic;Deimplementation;Dentistry;design;Development Plans;Disadvantaged;Discipline of Nursing;Dissemination and Implementation;economic evaluation;Educational Curriculum;Educational workshop;Effectiveness;effectiveness/implementation design;Emergency treatment;Funding;Grant;Health;health care consultation;Health Sciences;Health system;Healthcare;Healthcare Systems;implementation research;improved;Infrastructure;innovation;Institution;Institutional Review Boards;investigator training;Journals;Leadership;Learning;Medical center;medical schools;Mentored Clinical Scientist Development Program;Mentorship;multidisciplinary;National Center for Advancing Translational Sciences;Patients;Persons;Population Heterogeneity;Productivity;programs;Public Health Schools;Publishing;Research;Research Methodology;Safety;Science;Secure;Services;Site;success;Texas;Training;Translational Research;translational scientist;Universities;Woman

PROJECT_TITLE: CTSA K12 Program at The University of Texas Health Science Center at Houston

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 CI-7 (01)]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

PHR: PROJECT NARRATIVE  This postdoctoral T32 application is designed to train 3 translational science researchers at the postdoctoral level who will help build a community of clinical and translational scientists by leveraging the multi-institutional multi-disciplinary strengths of a Center for Clinical and Translational Sciences (CCTS) Clinical and Translational Science Award (CTSA) based at the University of Texas Health Science Center at Houston (UTH-H). Through the TL1 Training Core which preceded this application and was awarded as an educational arm of the CCTS CTSA, we have already successfully trained postdoctoral fellows who have gone onto productive jobs within the translational science spectrum. In this proposal, we will continue to train future leaders in translation science while integrating trainees from CCTS partner institutions across Texas, which will bring additional diversity to the T32 since these trainees draw upon the broad racial, ethnic, gender, economic and social backgrounds represented in Texas, and will enable the sharing of unique ideas and collaborative opportunities among our CCTS partners.

PI_NAMEs: CHANDRA, JOYA ;FROST, JEFFREY A. (contact)

PROGRAM_OFFICER_NAME: CONROY, JENNIE LYNN

PROJECT_TITLE: CTSA Postdoctoral T32 at the University of Texas Health Science Center at Houston


PHR: PROJECT NARRATIVE This predoctoral T32 application is seeking to train six translational science researchers at the predoctoral level who will build a community of clinical and translational scientists by leveraging the trans-institutional multi- disciplinary strengths of our Center for Clinical and Translational Sciences (CCTS) based at the University of Texas Health Science Center at Houston (UTH-H). Through a TL1 grant which preceded this application, awarded as the training core of the CCTS, we have trained 94 diverse and productive translational researchers, 57% of whom are female, 16% of whom are underrepresented and 31% of whom are faculty at domestic academic institutions. In the proposed training program, we will continue to train leaders in translation science while integrating trainees from CCTS partner institutions in south and east Texas, thereby bringing additional diversity to the T32 since these trainees will draw upon the broad racial, ethnic, gender, economic and social backgrounds represented in Texas.

PROGRAM_OFFICER_NAME: DIBELLO, ANTHONY THOMAS

PROJECT_TITLE: CTSA Predoctoral T32 at the University of Texas Health Science Center at Houston


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PHR: : The CCTS is uniquely positioned to advance translational science through strategic expansion and multi-disciplinary collaboration to maximize resources and diversify capabilities that accelerate the “translation” of scientific discoveries into patient-care. Our Hub will focus on the large population we serve across Texas to address specific needs, and design feasible approaches to make them applicable locally, regionally and nationally. Through Research, Training & Team Science, Community Engagement and Diversity, the CCTS will contribute to NCATS’ national efforts towards innovative solutions resulting in “better health for all”.

PI_NAMEs: FERNANDEZ, MARIA EULALIA;MCNEILL, LORNA H.;MCPHERSON, DAVID D (contact);MERIC-BERNSTAM, FUNDA ;REININGER, BELINDA ;SAVITZ, SEAN I;ZHANG, JIAJIE

PROJECT_TERMS: Acceleration;Acute;Address;Affect;Awareness;Cancer Center;career;Caring;Characteristics;Clinical;Clinical and Translational Science Awards;clinical center;Clinical Research;Clinical Sciences;clinical translation;Clinical Trials;Collaborations;Collection;Communication;Communities;community engagement;cost effective;Country;County Hospitals;COVID-19 patient;Creativeness;data management;denial of health care;design;Development;Diagnosis;disorder prevention;Disparate;Dissemination and Implementation;Doctor of Medicine;Ecosystem;Education;Education and Outreach;effective therapy;Effectiveness;effectiveness research;efficacious treatment;Elements;Evidence based intervention;Exclusion;experience;Fostering;Geography;Goals;Health;Health Disparities Research;health disparity;health equity;health equity promotion;Health Sciences;Healthcare;Hospitals;implementation science;improved;Informatics;innovation;Institution;Interdisciplinary Study;Intervention;Leadership;Life;Medical;Methods;Mission;Modeling;multidisciplinary;National Center for Advancing Translational Sciences;novel;Organizational Models;organizational structure;Output;Patient Care;patient population;Patients;Persons;Pilot Projects;Policies;Population;Population Heterogeneity;Positioning Attribute;Prevention strategy;programs;Public Health;Public Health Informatics;recruit;Research;Research Infrastructure;Research Personnel;Resources;response;Rice;Science;Security;socioeconomics;Strategic Planning;System;Texas;Training;translational approach;Translational Research;Translations;Underrepresented Populations;Underserved Population;Universities;Vision

PROJECT_TITLE: Center for Clinical and Translational Sciences

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 CI-9 (01)]


ADMINISTERING_IC: CE

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

ORG_CITY: RICHMOND

ORG_DEPT: PSYCHOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative The goal of the proposed research is to implement and evaluate a comprehensive community- level approach, Healthy Communities for Youth, that includes both a selective hospital-based prevention strategy, Emerging Leaders, and universal prevention strategies that increase Positive Youth Development opportunities through participatory action research, stakeholder education, community mobilization, and an overall focus on increasing community capacity for prevention. Key project aims are to evaluate the impact of Healthy Communities for Youth on community rates of youth violence using surveillance data and evaluate the impact of each violence prevention strategy on proximal outcomes including their impact on risk factors and protective processes related to multiple forms of youth violence.

PI_NAMEs: SULLIVAN, TERRI N (contact);THOMSON, NICHOLAS DAVID

PROJECT_TITLE: CE21-005 - VCU Healthy Communities for Youth: Evaluation of Violence Prevention Strategies to Prevent and Reduce Community Levels of Youth Violence


ORG_CITY: NEW ORLEANS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: CYE PROJECT NARRATIVE: The proposed Center for Youth Equity (CYE) at Tulane University would be the first CDC-funded Prevention Research Center in the Gulf South explicitly focused on youth violence prevention, despite a significant need for such a resource—especially in states like Louisiana, Mississippi, and Alabama with the top homicide rates in the country. The CYE is relevant to public health because it will integrate, build upon, and transform interdisciplinary research, outreach, and training programs to create a synergistic hub and resource for youth violence and injury prevention in the Gulf South region. The proposed center is relevant to the mission of the CDC's National Center for Injury Prevention and Control because it aims to prevent and reduce violence, injury, and their resulting consequences and health disparities, particularly in a hard-hit city like New Orleans, Louisiana and the Gulf South region.

PI_NAMEs: CONSTANS, JOSEPH I;THEALL, KATHERINE P (contact)

PROJECT_TITLE: CE21-005 - Center for Youth Equity (CYE) at Tulane University: A Community-Centered Approach to Youth Violence Prevention


ORG_CITY: LAWRENCE

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: Project Narrative Youth violence is a critical public health concern disproportionately affecting racial and ethnic youth. Comprehensive youth violence prevention strategies can improve community outcomes.

PI_NAMEs: THOMPSON, JOMELLA  (contact)

PROJECT_TITLE: CE21-005 - CDC Youth Violence Prevention Center- Kansas City   (YVPC- KC): Evaluation of a Comprehensive Approach to Address Youth Violence


ADMINISTERING_IC: DP

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_CITY: JACKSON

ORG_NAME: MISSISSIPPI STATE DEPARTMENT OF HEALTH

ORG_STATE: MS

PHR: PROJECT NARRATIVE Mississippi continues to experience health challenges among the state’s pregnant women and newborns. The Mississippi PRAMS Program collects population-based data that monitors key risk factors, maternal behaviors, and access to care for Mississippi mothers and their infants. These data are then used to provide services that improve the health outcomes of this vulnerable population.

PI_NAMEs: YOUNG, DORTHY  (contact)

PROJECT_TITLE: DP21-001 Mississippi Pregnancy Risk Assessment Monitoring System (PRAMS) - Component A


ADMINISTERING_IC: PS

IC_NAME: NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STD AND TB PREVENTION

ORG_CITY: NEW YORK

ORG_NAME: HUNTER COLLEGE

PHR: 8. PROJECT NARRATIVE This project supports federal Ending the HIV Epidemic goals by: a) operationalizing health department strategies to enhance adoption and sustainment of proven HIV prevention interventions; and b) applying a rigorous implementation science approach to evaluate their impact. As a collaboration between an academic research team with extensive implementation science expertise and one of the largest health departments in the country, this project has the potential to exert a significant and sustained impact on the field by generating findings that inform scale-up of EHE interventions to maximize accessibility, engagement, and health equity.

PI_NAMEs: GOLUB, SARIT A (contact)

PROJECT_TITLE: RFA-PS-21-002 Implementation Research to Enhance Equity- Focused HIV Prevention in New York City


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Multiple Sclerosis;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: BOSTON

ORG_DEPT: NUTRITION

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: NARRATIVE The incidence of multiple sclerosis (MS), one of the most common disabling neurological diseases in young adults, is rapidly increasing in the U.S. and other countries, particularly in African Americans and in women of all races. There is compelling evidence that vitamin D insufficiency is a modifiable risk factor for multiple sclerosis, but uncertainties remain on the levels of vitamin D needed to prevent MS in different groups defined by race, age, and gender. Purpose of this project is to fill these gaps and thus obtain the solid evidence that is needed to implement effective strategies for MS prevention.

PI_NAMEs: ASCHERIO, ALBERTO  (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: 20 year old;25-hydroxyvitamin D;active duty;Address;Adolescence;Adolescent and Young Adult;Adult;Affect;African American population;Age;Army Personnel;Black Populations;Blood specimen;Certification;Childhood;Chronic;Country;Data;Department of Defense;Disabling;Environmental Risk Factor;Etiology;evidence base;Family;Finland;Future;Gender;gene environment interaction;Genes;Genetic;Guidelines;Hispanic Populations;HLA-DRB1;Incidence;Individual;Intervention;Investigation;Knowledge;Laboratories;Life;Longitudinal Studies;Measures;men;Mendelian randomization;Military Personnel;modifiable risk;Multiple Sclerosis;Navy Personnel;Nervous System Disorder;Not Hispanic or Latino;novel therapeutics;Paper;prevent;Prevention;programs;Progressive Disease;prospective;Prospective Studies;Public Health;public health intervention;Public Health Practice;Publishing;Quality of life;Race;racial difference;Recommendation;Reporting;repository;Research;Risk;Risk Factors;risk variant;Role;Sampling;Serum;Societies;Solid;sound;Standardization;study population;Sweden;Testing;Time;Translating;Translational Research;Translations;Uncertainty;Variant;Vitamin D;Vitamin D-Binding Protein;White Women;Woman;young adult

PROJECT_TITLE: Prospective Study of Vitamin D and MS Risk in African Americans

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ADMINISTERING_IC: AG

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BERKELEY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE The field of Alzheimer’s disease (AD) research has entered the era of “big data”, where large, multicenter data sets have contributed greatly to our understanding of the clinical variability, epidemiology, and genetics of the disease. This project will create an infrastructure for obtaining standardized brain images that can be combined across the 30 Alzheimer’s Disease Centers to create a very large database. Because imaging has become an integral part of the assessment of patients with AD, this work will advance our capabilities for performing high quality research on virtually any topic in this field that is related to brain imaging.

PI_NAMEs: JACK, CLIFFORD R.;JAGUST, WILLIAM J. (contact)

PROGRAM_OFFICER_NAME: ELLIOTT, CERISE

PROJECT_TERMS: age-related disease;aging related;Agreement;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyloid;Amyloid deposition;Big Data;Biochemistry;Biological Markers;Brain;Brain imaging;Brain region;brain volume;Caring;cerebral microbleeds;cerebrovascular lesion;cerebrovascular pathology;Cerebrum;Clinical;clinical practice;Clinical Trials;Collection;community center;comorbidity;Complex;cost;Data;Data Collection;Data Set;Databases;Decision Making;Dedications;Dementia;demographics;Deposition;design;Development;Diagnosis;Diagnostic;Diffusion;Disease;Documentation;Epidemiology;Equipment;Evaluation;Exclusion;Genetic;Genetic Diseases;Glucose;glucose metabolism;Goals;Image;image archival system;image processing;imaging facilities;imaging modality;improved;Individual;Infrastructure;innovation;Label;Laboratories;Laboratory Research;large datasets;Leadership;Link;Magnetic Resonance Imaging;Measurement;Measures;metabolic imaging;Methods;Mission;mobile computing;Modeling;Multimodal Imaging;National Institute on Aging;neuroimaging;neuropathology;novel;novel strategies;open source;Participant;Patients;Perfusion;Phenotype;Play;Positron-Emission Tomography;Procedures;Productivity;programs;prospective;Protocols documentation;Psychometrics;Qualifying;Quality Control;Recommendation;Registries;Reporting;repository;Research;Research Personnel;Resolution;Resources;Role;Sampling;Science;searchable database;Secure;Sleep;Standardization;Structure;Surveys;tau Proteins;Therapeutic Studies;Thick;Time;virtual;web site;White Matter Hyperintensity;Work

PROJECT_TITLE: SCAN: Standardized Centralized Alzheimer's and Related Dementias Neuroimaging


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Burden of Illness;Caregiving Research;Clinical Research;Dementia;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative This work will provide nationally representative data for estimating the incidence of dementia in India for the first time. Its rich and comprehensive data on modifiable and non-modifiable risk factors of dementia will enable all interested researchers to investigate the relative contributions of key risk factors of dementia, and the longitudinal nature of the project will provide insight on the deterioration of cognitive abilities among the aged over time. The generated data will also enable researchers and policymakers to determine the costs and burdens associated with providing care for older persons with dementia.

PI_NAMEs: LEE, JINKOOK  (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Adopted;Aerosols;Age;Age Years;aged;Aging;Air Pollution;ambient air pollution;American;Android;Auditory system;base;biodemography;Biological;biological adaptation to stress;Biological Assay;Biology;Biomass;Blood;Brain;British;Cardiovascular system;care costs;care giving burden;Caregiver Burden;Caribbean region;Caring;Cellular Phone;Clinical;Clinical assessments;Coal;Cognition;Cognitive;cognitive ability;cognitive change;cognitive testing;Collection;Communities;Comparative Study;Consensus;cooking;cost;Country;Data;data harmonization;Data Set;Dementia;dementia burden;dementia risk;Deterioration;Diagnosis;Diagnostic;digital;Discipline;Economic Burden;Elderly;Eligibility Determination;ethnic diversity;European;Exhibits;Exposure to;fine particles;follow-up;Fundus photography;Generations;Geography;Geriatrics;Goals;Government;Guidelines;Health;Health and Retirement Study;hearing impairment;Hearing Tests;Household;illiterate;Impaired cognition;improved;Incidence;Income;India;Individual;Inflammatory;informal caregiver;informant;innovation;insight;interest;International;Intervention;Interview;Investigation;Journals;late life;Long-Term Care;Longitudinal Studies;Measurement;Measures;Medical;Metabolic;Methodology;mobile sensor;Modeling;Monitor;Nature;older adult;Older Population;Optics;Paper;Periodicity;Peripheral;Policies;Policy Maker;Population;Population Heterogeneity;Prevention;Protocols documentation;Publishing;recruit;Reporting;Research;Research Personnel;Respondent;Retina;Risk Factors;Role;Sampling;Sensory impairment;sensory system;Serum;social;Societies;sociodemographics;Source;South African;spatiotemporal;Stress;Surveys;tau Proteins;tau-1;Technology;Testing;Time;Training;Transportation;Venous;Visual;Visual impairment;webinar;Work

PROJECT_TITLE: Harmonized Diagnostic Assessment of Dementia (DAD) for Longitudinal Aging Surveys in India (LASI)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-C(02)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Project Narrative Upon the completion of proposed research, we expect to advance our understanding of molecular pathways controlling B cell tolerance checkpoints. Functional analysis of miR-148a and its target genes may reveal an entire network of protein coding genes important for these processes, which may be valuable diagnostic markers and possible therapeutic targets for autoimmune diseases.

PI_NAMEs: NEMAZEE, DAVID  (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Ablation;Acceleration;Anabolism;Animals;Autoimmune Diseases;Autoimmunity;autoreactive B cell;B-Lymphocytes;Biodiversity;Biological Process;Bone Marrow;cancer immunotherapy;central tolerance;Chemicals;Code;Communication;Defect;design;Development;diagnostic biomarker;Disease;Dissection;Enzymes;Failure;GADD45A gene;Genes;Genetic;Glycolipids;Graft Rejection;Grant;Hematopoietic System;Immune system;Immune Tolerance;Immunology;immunoregulation;In Vitro;in vivo;Inbred MRL lpr Mice;inhibitor;Knockout Mice;lupus-like;Lymphocyte;MicroRNAs;Modeling;Molecular;Molecular Analysis;mouse model;Mouse Strains;Mutant Strains Mice;Nature;novel;novel therapeutic intervention;Pathway interactions;Patients;Peripheral;peripheral tolerance;plasma cell differentiation;Play;prevent;Process;Proteins;Research;Role;systemic autoimmunity;Therapeutic;therapeutic target;Transgenic Organisms;Untranslated RNA

PROJECT_TITLE: Functional Analysis of MicroRNAs and Target Genes in Immune Tolerance

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Cerebral Palsy;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Activity;Physical Rehabilitation;Rehabilitation

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: Project Narrative: The proposed project is relevant to public health because the discovery of effective gait training strategies and underlying muscular mechanisms is expected to positively effect changes in community-based walking activity and mobility for children with cerebral palsy (CP). This knowledge will inform current and future locomotor rehabilitation strategies for persons with neuromotor limitations. Thus, the proposed research is relevant to the NICHD’s mission pertaining to development of knowledge that ensures the health, productivity, independence and well-being of people through optimal rehabilitation.

PI_NAMEs: BJORNSON, KRISTIE F (contact);MOREAU, NOELLE G

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Accelerometer;Address;Adult;age related;age related decline;Body Weight;Cerebral Palsy;Child;Childhood;Clinical;clinical examination;clinical implementation;clinical practice;Clinical Trials;Communities;community setting;cost;Data;design;Development;disability;dosage;Ensure;Exhibits;Family;functional decline;Future;Gait;gait rehabilitation;Gait speed;Generations;Global Positioning System;Health;Home;Impairment;improved;improved mobility;Individual;innovation;Interval training;Intervention;Knowledge;Learning;Life;life span;Literature;Location;Locomotor training;Lower Extremity;Measures;Mediating;Mission;Modeling;motor learning;Motor Skills;Muscle;National Institute of Child Health and Human Development;novel;novel therapeutic intervention;Outcome;Outcome Assessment;Patient Outcomes Assessments;Patients;Pattern;Performance;Personal Satisfaction;Persons;Physical activity;Population;primary endpoint;primary outcome;Productivity;Protocols documentation;Public Health;randomized, clinical trials;Recommendation;rehabilitation strategy;Rehabilitation therapy;Reporting;Research;Risk;robot assistance;Schedule;Schools;Soccer;Spastic Cerebral Palsy;Testing;Time;Training;Translating;treadmill training;treatment effect;vigorous intensity;Walking;walking performance;walking speed;Work

PROJECT_TITLE: Short-Burst Interval Treadmill Training to Improve Community Walking Activity and Mobility in Cerebral Palsy

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: CA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Esophageal Cancer;Genetics;Human Genome;Obesity;Prevention;Rare Diseases

PHR: PROJECT NARRATIVE The incidence of esophageal adenocarcinoma (EAC), a deadly cancer, has risen rapidly in the United States. In this study, we will characterize the primary driving forces transforming Barrett’s esophagus into malignant EAC using advanced epigenomic approaches. Furthermore, we will investigate the mechanistic basis of the strong association between obesity and EAC. Our results hold the promise to fundamentally transform the understanding of neoplastic evolution of esophagus, while simultaneously discovering novel driver genes, pathways and potential actionable targets for EAC.

PI_NAMEs: LIN, DE-CHEN  (contact)

PROGRAM_OFFICER_NAME: YASSIN, RIHAB R

PROJECT_TERMS: 3-Dimensional;Adenocarcinoma Cell;ARID1A gene;ATAC-seq;Barrett Esophagus;Benign;Biological;Biological Assay;Biological Markers;Biological Process;Biology;cancer cell;Cell Line;Cell Physiology;Cell Proliferation;Cells;Chemicals;ChIP-seq;Chromatin;Chromatin Conformation Capture and Sequencing;combinatorial;Country;CRISPR interference;Data;Development;Disease;driving force;Early identification;Early Intervention;ELF3 gene;Enhancers;Epigenetic Process;epigenome;epigenomics;Epithelial Cells;Esophageal Adenocarcinoma;Esophagogastric Junction;Esophagus;European;Event;Evolution;experimental study;Fatty Acids;FDA approved;Feedback;Foundations;Genes;Genetic Transcription;genome-wide;Genomics;Glean;High Fat Diet;high risk population;Human;improved;Incidence;inhibitor;insight;interest;Intervention;Investigation;Lesion;Link;lipidomics;loss of function;Malignant - descriptor;Malignant neoplasm of esophagus;Malignant Neoplasms;Mass Spectrum Analysis;Modeling;Molecular;mouse model;Mutation;Neoplasms;neoplastic;novel;Nuclear Receptors;Obesity;Oncogenic;Organoids;Pathway interactions;Patients;PF4 Gene;Pharmaceutical Preparations;PPAR gamma;Precancerous Conditions;premalignant;preventive intervention;profiles in patients;Proliferating;Refractory;Regulation;Regulatory Element;Research;research clinical testing;Risk;Risk Factors;Sampling;Signal Pathway;Testing;Therapeutic;TP53 gene;transcription factor;transcriptome;transcriptome sequencing;Translating;Treatment Protocols;United States;Xenograft procedure

PROJECT_TITLE: Master regulator transcription factors promote esophageal neoplastic evolution

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: GAINESVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: FL

PHR: More than 42,000 individuals with spinal cord injury (SCI) are eligible for treatment in the VA Healthcare System, with direct healthcare expenditures exceeding $716 million/year. Bone loss is a hallmark of severe SCI that produces 20- to 100-fold higher fracture risk, with extended post-fracture hospitalization. Moreover, the risk for respiratory illness, venous thromboembolic events, pressure ulcers, urinary tract infections, and other medial comorbidities more than doubles in persons with SCI within 1-month of fracture, which contributes to the 30% higher 5-yr mortality risk that exists for those with versus without fracture after SCI. Despite these consequences, no physical rehabilitation regimen or pharmacologic therapy has been shown to consistently improve BMD recovery after SCI or to completely prevent bone loss at the most fracture prone sites in this population. These findings provide strong justification for studies that focus on identifying and optimizing strategies to improve skeletal integrity and reduce fracture incidence in Veterans with SCI.

PI_NAMEs: YARROW, JOSHUA F. (contact)

PROJECT_TERMS: Activities of Daily Living;Address;Algorithms;base;Bicycling;Body Composition;bone;Bone Density;bone loss;Central Nervous System;Clinical Trials;cohort;comorbidity;cost effective;Coupled;Data;decubitus ulcer;design;Development;Distal;Electric Stimulation;Electrodes;Eligibility Determination;Ensure;Event;Exercise;Exhibits;Feedback;Femur;Fracture;fracture risk;Frequencies;Functional disorder;functional electrical stimulation;Future;Goals;Health Expenditures;Healthcare Systems;high reward;high risk;Hospitalization;Human;Hybrids;Impairment;improved;Incidence;Individual;innovation;Isotonic Exercise;Legal patent;Limb structure;Location;Maps;Medial;Medical;Minor;Modality;Modeling;mortality risk;Motion;Motor;motor control;Muscle;Musculoskeletal;novel;Outcome;Paralysed;Persons;pharmacologic;Physical Rehabilitation;Physical therapy;Physiologic pulse;Population;Positioning Attribute;pre-clinical;prevent;primary outcome;Rattus;Records;Recovery;Reflex action;Regimen;rehabilitation strategy;Reporting;Resistance;respiratory;response;restoration;Risk;Rodent;sensor;Site;skeletal;Spinal Cord Contusions;Spinal cord injury;spinal tract;spontaneous pain;success;System;Testing;tibia;Time;Torque;Training;Translating;Urinary tract infection;Validation;Venous;Veterans;Width

PROJECT_TITLE: Development and Validation of a Rodent FES Bicycle System

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Social Determinants of Health

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative The proposed study considers how wealth and wealth deprivation contribute to youth problem behaviors. It will comprehensively test four psychosocial pathways as potential mediators linking wealth to problem behaviors, as well as provide descriptive data about variations in wealth over time within a socioeconomically and racially/ethnically diverse group of families with adolescents. Such information will be critical for the development of prevention and intervention efforts aimed at promoting adolescents' psychosocial functioning in economically marginalized families.

PI_NAMEs: MILLER, PORTIA  (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Address;Adolescence;Adolescent;Adolescent Development;Affect;Age;American;Attention;Automobile Driving;Behavioral;behavioral health;Buffers;Caregivers;Child;Child Rearing;Cities;cohort;Color;Complement;Data;Data Sources;deprivation;Development;Dimensions;Disparity;economic disparity;Economic Factors;Economics;ethnic diversity;Ethnic Origin;Ethnic Population;Exclusion;expectation;experience;Family;Family Process;Future;Growth;Household;Income;income disparities;Individual;Inequality;Intervention;Investigation;Investments;Knowledge;Link;Literature;Longitudinal Studies;low socioeconomic status;marginalization;Measures;Mediator;Mental Health;Modality;National Institute of Child Health and Human Development;Pathway interactions;Perception;Personal Satisfaction;Poverty;Prevention;Problem behavior;protective effect;psychologic;psychosocial;Race;racial diversity;racial population;Reporting;Research;Risk;Role;Sampling;Shapes;Social Class;Socioeconomic Status;socioeconomics;Source;Stress;Surgeon;Testing;Time;Variant;Youth

PROJECT_TITLE: A Different Type of Economic Fragility: Wealth and Adolescent Problem Behavior

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Rare Diseases;Social Determinants of Health;Vector-Borne Diseases

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Mosquitoes that prefer to live among and bite humans spread the most disease. Recent work suggests that populations of the dengue, Zika, chikungunya, and yellow fever mosquito Aedes aegypti are evolving a greater preference for human hosts in the rapidly growing cities of sub-Saharan Africa. This project is designed to test this prediction in the field, across urban-rural gradients in Ouagadougou, Burkina Faso and Kumasi, Ghana, and identify specific genes associated with this behavioral shift.

PI_NAMEs: ROSE, NOAH H (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Aedes;Africa;Africa South of the Sahara;Alleles;Animals;Automobile Driving;Bar Codes;Behavioral;Biological Assay;Blood;Burkina Faso;chikungunya;Chikungunya fever;Cities;Collaborations;Collection;Culicidae;Data;Dengue;Dengue Fever;design;Disease;Disease Vectors;disorder risk;DNA Resequencing;feeding;Female;Future;General Practitioners;Genes;Genetic;Genome;genome sequencing;genome-wide;Genomics;Ghana;Goals;Growth;Habitats;high risk;Human;Human Bites;Individual;Individual Differences;Laboratories;Laboratory Finding;Lead;Link;Location;Modeling;Molecular;Monitor;Mosquito-borne infectious disease;Odors;Outcome;peri-urban;Persons;Population;Population Density;Population Projection;preference;prevent;Productivity;Public Health;Publishing;Reporting;response;Role;Rural;rural area;Sampling;Site;Source;Specialist;Testing;tool;Translating;United Nations;urban area;Urban Population;urban setting;Urbanization;vector;whole genome;Work;Yellow Fever;ZIKA;zika fever

PROJECT_TITLE: Genomic Analysis of Aedes aegypti Host Preference Across Urban-Rural Gradients in Africa

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


PHR: Closed head traumatic brain injury (CH-TBI) has been a major component of injury in Iraq and Afghanistan with lingering quality of life eroding disabilities such as spasticity, gait, balance, anxiety and cognitive disorders that produce a substantial health care responsibility. There are also rapidly growing concerns that TBI is a risk factor for lingering inflammation that can significantly increase the risk of progressive neurodegenerative disorders in the future. Accordingly, there is an urgent need to increase our understanding of injury-induced long-term disability mechanisms, and to test the safety and efficacy of therapeutic measures that target these mechanisms utilizing approaches that have excellent potential for rapid translation. The proposed studies focus on TBI- induced microbleeds mediated neural, vascular, and inflammatory injury and their treatment. Translation of these findings may provide safe and effective intervention strategies that can significantly benefit the veterans’ health care system.

PI_NAMEs: BOSE, PRODIP K. (contact);THOMPSON, FLOYD J.

PROJECT_TERMS: 3-nitrotyrosine;Acceleration;Address;Affect;Afghanistan;Aftercare;Amygdaloid structure;Animals;Anti-Inflammatory Agents;Anxiety;Anxiety Disorders;Apoptosis;Area;Behavior;behavior test;behavioral study;Biological Assay;biomarker evaluation;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Vessels;Brain;Brain Stem;brain tissue;Brain-Derived Neurotrophic Factor;Caring;catalyst;Cell Death;Cell Nucleus;Characteristics;Chelating Agents;chelation;Chronic;Chronic disability;Chronic Disease;Clinical Treatment;clinically relevant;Cognition Disorders;Cognitive;cognitive disability;cognitive function;Data;Deceleration;Deferoxamine;Degenerative Disorder;Deposition;Diffuse;Diffuse Axonal Injury;disability;Disease;Dose;effective intervention;effective therapy;efficacy evaluation;Endothelium;equilibration disorder;Equilibrium;Excision;experimental study;Florida;Foundations;Future;Gait;Gait abnormality;Gliosis;Head;healing;Health system;Healthcare;Healthcare Systems;Hemorrhage;Hippocampus;Histologic;Histology;Human;Image;Immunohistochemistry;improved;in vivo;Inflammation;Inflammatory;inflammatory marker;Injury;innovation;insight;Interleukin-5;Intervention;Iraq;Iron;Legal patent;locus ceruleus structure;Long term disability;Magnetic Resonance Imaging;Maps;Measures;Mediating;Modeling;Molecular;Morbidity - disease rate;Motor;Motor disability;motor disorder;Nerve Degeneration;nerve injury;nerve supply;neural;Neurobiology;Neurodegenerative Disorders;neuroinflammation;New Agents;NF-kappa B;noradrenergic;Oxidative Stress Induction;Pathway interactions;Pharmaceutical Preparations;Phenotype;Population;Positioning Attribute;preclinical evaluation;preclinical study;Preclinical Testing;Predisposition;Prevention strategy;Progressive Disease;protective factors;Protocols documentation;Quality of life;Reactive Oxygen Species;rehabilitation strategy;Rehabilitation therapy;Reporting;Research;Risk;Risk Factors;Rodent Model;Safety;safety testing;sensory cortex;spasticity;TBI treatment;Testing;Therapeutic;therapy development;Tight Junctions;Time;Tissues;TNF gene;Toxic effect;translational potential;Translations;Traumatic Brain Injury;Treatment Efficacy;treatment strategy;Universities;Up-Regulation;Vascular Endothelial Growth Factors;vascular inflammation;Vestibular nucleus structure;Veterans;white matter;Work

PROJECT_TITLE: Efficacy and safety of a new hexadentate iron chelator therapy for TBI-induced chronic disabilities in a rodent model

STUDY_SECTION_NAME: Brain Health and Injury[RRD1]


ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE This proposal will recruit and train diverse young researchers so that they can translate cell and gene based therapies from basic science laboratories into clinical development. These therapies hold great promise for regenerative medicine, cancer and other disorders, but can only be implemented after the specialized training provided by this award.

PI_NAMEs: BRENNER, MALCOLM K.;HESLOP, HELEN E (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Cell Therapy;gene therapy;Training

PROJECT_TITLE: Training In Cell and Gene Therapy

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the discovery of the mechanisms through which the tyrosine phosphatase PRL3 drives leukemia progression is expected to re-define the roles that phosphatases can have in cancer. The proposed research is therefore relevant to the NCI mission because it will provide a strong impetus for the development of phosphatase inhibitors, which will be a new class of targeted therapy for cancer patients.

PI_NAMEs: BLACKBURN, JESSICA S. (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: acute lymphoblastic leukemia cell;Acute Lymphocytic Leukemia;Adult;Adverse effects;antileukemic activity;Apoptosis;Binding Sites;Biochemical;Biotin;Cancer Patient;cancer type;Cells;Cessation of life;chemotherapy;Child;Clinic;Clinical Trials;Collaborations;Cytotoxic Chemotherapy;Data;Defect;Development;Developmental Delay Disorders;Diagnosis;Disease;Disease Progression;DNA-Binding Proteins;Drug Targeting;Enhancers;Family;FDA approved;Gene Chips;General Population;Genes;Genetic Transcription;Growth;Human;Human Cell Line;In Vitro;in vivo;inhibitor;innovation;Kinetics;knock-down;Knowledge;leukemia;Leukemic Cell;Life;Ligase;Link;Maintenance;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;member;Methods;Mission;Modeling;Molecular Target;molecular targeted therapies;MYC gene;Normal Cell;novel;Nucleic Acid Regulatory Sequences;Oncogenes;Oncogenic;Organ;Outcomes Research;Pathway interactions;patient derived xenograft model;Patients;pediatric patients;Phenotype;phosphatase inhibitor;Phosphoric Monoester Hydrolases;Play;Preclinical Testing;preclinical trial;Prognosis;Protein Array;Protein Tyrosine Phosphatase;Public Health;Regimen;Relapse;Research;Role;Sampling;Second Primary Cancers;side effect;Signal Pathway;Single Nucleotide Polymorphism;small molecule;synergism;targeted cancer therapy;targeted treatment;Testing;Therapeutic;therapeutic target;TP53 gene;transcription factor;Transcriptional Regulation;translational impact;Transplantation;tumor progression;Tumor Suppressor Proteins;Zebrafish

PROJECT_TITLE: The Phosphatase PRL3 as a MYC Target and Pro-Survival Oncogene in Acute Lymphoblastic Leukemia


NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Contraception/Reproduction;Genetics;Infertility;Pediatric;Urologic Diseases

ORG_CITY: ORLANDO

ORG_NAME: NEMOURS CHILDREN'S HOSPITAL, ORLANDO

PHR: PROJECT NARRATIVE: Although birth defects of the genitourinary (GU) tract are common, the cause of such defects remains largely unknown. This study aims to understand the causes of common GU tract birth defects by identifying new genes that may play a role in development of the urinary tract.

PI_NAMEs: SETH, ABHISHEK  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: 16p11.2;Actins;Affect;Androgen Receptor;Birth;Cell Line;cell motility;Complex;Congenital Abnormality;Copy Number Polymorphism;Critical Pathways;Cryptorchidism;CUL3 gene;Cytoskeletal Modeling;Cytoskeleton;Data;Defect;design;Development;Diagnosis;Diagnostic Reagent Kits;Disease;Essential Genes;Exhibits;experimental study;Feminization;Gametogenesis;Gene Dosage;Gene Targeting;Genes;Genetic;Genitalia;Genitourinary system;Germ Cells;Goals;gonad development;High Prevalence;Human;Hypospadias;In Vitro;in vitro Model;in vivo;Incidence;Individual;Intercellular Junctions;knock-down;Knockout Mice;Knowledge;Lesion;Link;Maintenance;male;Male Genital Organs;Malignant Neoplasms;Masculine;Mediating;Molecular;mouse model;mRNA Expression;Mus;Mutant Strains Mice;Mutation;Neurologic;Newborn Infant;overexpression;Pathway interactions;Patients;penis;Physiological;Proteins;RBX1 gene;receptor expression;Receptor Signaling;Recovery;Regulation;RHOA gene;Risk;Role;Seminal Vesicles;sertoli cell;Sex Behavior;sex development disorder;Sex Differentiation;Signal Transduction;subfertility;Testing;Testis;Tissues;tool;ubiquitin-protein ligase;Ubiquitination;Up-Regulation;Urinary tract;Urination;urogenital tract;Virilism

PROJECT_TITLE: The Role of E3-Ubiquitin Ligase Complex in Genitourinary Tract Development and Function

STUDY_SECTION: KMBD

STUDY_SECTION_NAME: Kidney Molecular Biology and Genitourinary Organ Development[KMBD]


NIH_SPENDING_CATS: Asthma;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Pediatric;Precision Medicine;Prevention;Social Determinants of Health

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Asthma remains one of the most important challenges to pediatric public health in the United States affecting millions of children and adults, particularly in vulnerable urban populations; the molecular, environmental and genetic bases for this burden remain incompletely understood. We will contribute extensively to the Childhood Asthma in Urban Settings Clinical Research Centers Network (CAUSE) as a Clinical Research Unit through successful implementation, scientific expertise, and training of the next generation of NIH funded investigators skilled in asthma. Based on our previous work on novel NOTCH4 mechanistic pathways on airway inflammation, we will specifically examine the role that NOTCH4 signaling acts to regulate airway inflammation and increases asthma severity and loss of asthma control in urban school children, enlightening our understanding of pathways and mechanisms that may pave the way for future targeted novel biomarker driven approaches and improve the lives of vulnerable urban children with asthma.

PI_NAMEs: CHATILA, TALAL AMINE;PHIPATANAKUL, WANDA  (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Address;Adult;Affect;airway hyperresponsiveness;airway inflammation;Allergens;Allergic Disease;Asthma;asthmatic;asthmatic patient;base;Bioinformatics;Biology;biomarker driven;Biometry;Boston;Cells;Child;Childhood;Childhood Asthma;Chronic;Clinic;Clinical;clinical center;Clinical Research;Clinical Trials;Code;cohort;Cohort Studies;Data;data management;Databases;Disadvantaged;Disease;disorder control;Endotoxins;Environment;Environmental Exposure;Environmental Risk Factor;experience;Family;Functional disorder;fundamental research;Funding;Future;gene environment interaction;Generations;Genes;Genetic;Genetic Risk;genetic variant;Health;Health Insurance;Home;Human;Human Resources;Hypersensitivity;Immune Tolerance;Immunology;improved;Income;Inflammation;Inflammatory;Infrastructure;inner city;Institutional Review Boards;interest;Interleukin 4 Receptor;Interleukin-6;Knowledge;Laboratories;laboratory facility;Laboratory Research;Licensing;Lung;Mediating;Minority Groups;modifiable risk;Molecular;Morbidity - disease rate;mortality;Mus;National Institute of Allergy and Infectious Disease;next generation;NOTCH4 gene;novel;novel marker;novel therapeutic intervention;Observational Study;Outcome;Pathway interactions;patient population;Patient Recruitments;Patients;Pediatric Hospitals;pediatric patients;peripheral blood;personalized medicine;Pharmaceutical Services;Phenotype;pollutant;Population;Poverty;Precision therapeutics;Prevalence;Process;protein expression;Protocols documentation;Public Health;Quality Control;Records;recruit;Regulatory T-Lymphocyte;repository;Research;research facility;Research Personnel;Risk Factors;Role;Sampling;Schools;Seasons;Severities;Severity of illness;Shipping;Signal Transduction;skills;statistics;T-Lymphocyte;Testing;Tissues;Training;United States;United States National Institutes of Health;urban area;urban children;Urban Population;urban school;urban setting;Variant;Vulnerable Populations;Work

PROJECT_TITLE: Novel NOTCH4 Pathway of Asthma Severity in Urban School Children: Clinical Research Center, Boston Children’s Hospital


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Genetics;Infertility

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative PIWI-interacting RNA (piRNA)-mediated silencing of transposable elements is critical in preserving the integrity of the genome in germ cells, with the loss of the piRNA pathway leading to sterility and potentially aging and cancer. Recent studies indicate that piRNAs are expressed in a sexually dimorphic manner and yet the mechanisms by which this occurs remains poorly understood. In this proposal, I aim to characterize the sex- specific transcription complexes that uniquely drive the expression of male and female piRNAs and explore the surprising molecular link to the transcription of snRNAs of the spliceosome.

PI_NAMEs: BENNER, LARS  (contact)

PROJECT_TERMS: Address;Adult;Aging;Alzheimer's Disease;Amino Acid Motifs;Amino Acid Sequence;Animals;Binding;Binding Proteins;Binding Sites;Biogenesis;Caenorhabditis elegans;Complement;Complex;CRISPR/Cas technology;Data;Disease;DNA Binding;DNA Transposable Elements;DNA-Binding Proteins;Drosophila melanogaster;Exhibits;Exonuclease;experimental study;Family;Female;Fertility;Fertility Disorders;fly;Gene Targeting;Genetic Transcription;genome integrity;Genomic Instability;genomic locus;Genomics;Germ Cells;Germ Lines;Global Change;Human;Hybrids;Infertility;insight;Knowledge;Link;male;Male Infertility;Malignant Neoplasms;Mammals;Mediating;model organism;Molecular;Mus;mutant;Nematoda;Neurons;offspring;Organism;Orthologous Gene;paralogous gene;Pathway interactions;piRNA;Play;preservation;protein complex;Protein Family;Proteins;Reagent;recruit;Repression;RNA;RNA Splicing;Role;sex;sexual dimorphism;Small Nuclear RNA;Small RNA;Specific qualifier value;Specificity;Spliceosomes;Sterility;Tertiary Protein Structure;Testis;transcription factor;transcriptome sequencing;Work;Zebrafish

PROJECT_TITLE: The molecular characterization of sex-specific piRNA transcription and snRNA transcription in C. elegans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Disability Research;Machine Learning and Artificial Intelligence;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: ATLANTA

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Advancing current rehabilitation approaches is limited by an inability to robustly identify individual-specific differences in gait impairments. In this project, we aim to develop a sensitive, data-driven, consistent tool using continuous, multi-joint gait dynamics to characterize individual-specific differences in stroke gait and evaluate individuals’ potential to improve their ankle push-off with exposure to a single session of functional electrical stimulation (FES) delivered during fast walking (FastFES). Understanding individual-specific gait impairments is necessary for the development of tailored rehabilitation approaches to potentially correct the high variation of gait impairments amongst stroke survivors.

PI_NAMEs: WINNER, TANIEL SOLARNGE (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: Address;Adverse effects;Affect;Ankle;ankle joint dorsiflexor;Ataxia;Bilateral;biomechanical model;Biomechanics;Case Series;Characteristics;chronic stroke;Coin;Complex;Cross-Sectional Studies;Data;Descriptor;Development;Euclidean Space;Exposure to;Flexor;Foot-drop;functional electrical stimulation;Future;Gait;Gait abnormality;gait rehabilitation;Gait speed;gait symmetry;Goals;Heterogeneity;Hip region structure;Impairment;improved;Individual;inter-individual variation;Intervention;Joints;kinematics;Kinetics;Knee;Knee joint;Knowledge;Learning;Limb structure;Literature;Lower Extremity;Maps;Measures;Mentors;Modality;Modeling;Movement;Muscle;Neural Network Simulation;Neuromechanics;neuroregulation;Paresis;Phase;Physics;post stroke;recurrent neural network;rehabilitation strategy;Rehabilitation therapy;Research;Research Personnel;responders and non-responders;response;Sampling;Stroke;stroke rehabilitation;stroke survivor;Study Subject;support vector machine;System;Techniques;Testing;theories;Time;tool;Torque;Training;treatment response;two-dimensional;unsupervised clustering;Variant;Walking;walking speed;Work

PROJECT_TITLE: Identifying individual-specific gait signatures for stroke rehabilitation


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Project narrative Hereditary spastic paraplegias (HSP) are inherited disorder of long central axons in the corticospinal tracts. More than half of all affected families currently remain without a definite diagnosis because the underlying genetic factors that cause their disease have not been identified yet. Our study aims to use whole genome sequencing in exome -negative patients to identify these unknown HSP genes. We also plan a large SPG4 modifier study. This will ultimately allow to devise strategies to treat these diseases.

PI_NAMEs: SCHULE, REBECCA E;ZUCHNER, STEPHAN  (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Affect;Age of Onset;Alleles;Alternative Splicing;Area;Axon;Bioinformatics;Biological Models;Cells;Classification;Clinical;Clinical Data;Clinical Trials;cohort;Collaborations;Collection;Computer software;Corticospinal Tracts;Data;Data Collection;data mining;Data Reporting;data sharing;Diagnosis;Diagnostic;Disease;DNA;Dominant Genetic Conditions;Elements;exome;exome sequencing;experimental study;Family;follow-up;gene discovery;Gene Dosage;gene therapy;gene-targeted therapy;Genes;Genetic;Genome;genome analysis;genome sequencing;Genotype;Geography;Hereditary Disease;Hereditary Spastic Paraplegia;heuristics;Human;indexing;Induced pluripotent stem cell derived neurons;Inherited;innovation;International;Knowledge;Language;Link;loss of function;member;Minority;Modeling;Motor Neurons;Mutation;Nervous System Disorder;novel;offspring;Onset of illness;Ontology;Parents;participant enrollment;Pathogenicity;Pathway interactions;patient advocacy group;patient engagement;Patient Outcomes Assessments;patient portal;Patient Selection;Patients;Peripheral Blood Mononuclear Cell;Phenotype;phenotypic data;preclinical study;Preparation;Probability;Protein Isoforms;Pseudogenes;Publishing;Rare Diseases;Readability;Registries;Resources;RNA;sample collection;Sampling;Scientist;Severities;Site;Spastic Paraplegia;Standardization;success;Technology;Testing;therapeutic target;Time;transcriptome sequencing;Uniparental Disomy;Untranslated RNA;Validation;Variant;whole genome

PROJECT_TITLE: Genome Studies in Hereditary Spastic Paraplegia- Beyond the Exome

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


PHR: PROJECT NARRATIVE PIWI-interacting RNAs (piRNAs) are expressed in a sex-specific manner across many species, including human. Understanding how sex-specific piRNA expression regulates germline gene expression is paramount to advancing our knowledge of piRNA-mediated regulation beyond transposon silencing and improving therapeutic strategies for infertility. Using C. elegans as a model, the proposed research will define regulatory machinery underlying sex-specific piRNA expression and identify endogenous gene targets of piRNAs to provide a deeper understanding of piRNAs in germline development.

PI_NAMEs: STAROSTIK, MARGARET  (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Algorithms;Animals;Base Pairing;Binding;Biogenesis;Biological;Biological Assay;Biological Process;Caenorhabditis elegans;ChIP-seq;Cleavage Under Targets and Release Using Nuclease;comparative;Complex;computerized tools;Consensus Sequence;CRISPR/Cas technology;Data;Databases;Defect;density;design;Development;differential expression;Disease;DNA Transposable Elements;DNA-Binding Proteins;Drosophila genus;Elements;Embryonic Development;Epigenetic Process;experimental study;Female;Fertility;Fertility Disorders;fly;Gametogenesis;Gene Expression;Gene Expression Regulation;Gene Silencing;Gene Targeting;Genes;Genetic Transcription;genome integrity;Germ Lines;Human;human disease;improved;Individual;Infertility;insight;Knowledge;Literature;male;male fertility;Mammals;Mediating;Men's Role;Modeling;Modification;Molecular;mRNA sequencing;mRNA Stability;Mus;Mutagenesis;mutant;Mutate;Mutation;novel;Nucleotides;Oogenesis;Pathway interactions;Pattern;Physiology;piRNA;posttranscriptional;preservation;Process;Production;promoter;Regulation;Regulatory Element;Reporter;Reporting;Research;Resolution;RNA;Role;selective expression;sex;sexual dimorphism;Site;Site-Directed Mutagenesis;Small Interfering RNA;Small RNA;Specific qualifier value;sperm cell;Sperm Maturation;Spermatogenesis;Testing;Therapeutic;Trans-Activators;transcription factor;transcriptome sequencing;Translations;Untranslated RNA

PROJECT_TITLE: Regulation of endogenous genes by sexually dimorphic piRNA expression during germline development in C. elegans


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: NORFOLK

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: OLD DOMINION UNIVERSITY

PHR: G-RISE at Old Dominion University Project Narrative We request support to establish a Graduate Research Training Initiative for Student Enhancement (G-RISE) program at Old Dominion University (ODU). This comprehensive program aims to recruit and train underrepresented students pursuing doctorate degrees in the biomedical research or related fields through research experiences, mentoring, educational and career development activities to prepare them to enter and succeed in a biomedical research career.

PI_NAMEs: NAWARATHNA, DHARMAKEERTHI  (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Universities

PROJECT_TITLE: G-RISE at Old Dominion University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Project Narrative Viral diseases remain a leading cause of death worldwide, necessitating an increase in training in virology. The complexity and diversity of persistence and pathogenesis mechanisms utilized by viruses pose major challenges to the development of effective vaccines and chemical or immune-based treatments of viral diseases. A goal of the training program is the recruitment of undergraduates and recent Ph.D. graduates in related disciplines (biochemistry, biological sciences, cellular and molecular biology, etc) into advanced studies in mechanisms of viral persistence and pathogenesis.

PI_NAMEs: DELUCA, NEAL A. (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Pathogenesis;Viral

PROJECT_TITLE: Viral Persistence and Pathogenesis

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Networking and Information Technology R&D (NITRD);Prevention;Telehealth

ORG_CITY: ANN ARBOR

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative About 1.6 million people in the U.S. have type 1 diabetes, who face the daily threat of developing dangerously low blood glucose episodes, potentially resulting in confusion, life-threatening cardiac events, or even death. Despite using advanced diabetes technologies such as continuous glucose monitors, many patients continue to develop these devastating episodes due to sub-optimal management of low blood glucose events. This research project will expand knowledge of type 1 diabetes patients’ beliefs that prevent them from treating low blood glucose episodes; resultant insight will be applied to develop and pilot test a patient-centered behavior- changing program to improve patients’ self-management of low blood glucose episodes.

PI_NAMEs: LIN, YU KUEI  (contact)

PROGRAM_OFFICER_NAME: THORNTON, PAMELA L

PROJECT_TERMS: Address;Adult;Applications Grants;arm;Arrhythmia;Award;Behavior;behavior change;Behavior Therapy;behavioral clinical trial;Behavioral Research;Behavioral Sciences;Belief;Blood Glucose;Cardiac;career;career development;Cellular Phone;Cessation of life;Clinical;Clinical Trials;cognitive function;Complex;Confusion;Continuous Glucose Monitor;Control Groups;Dangerousness;Data;Dedications;design;Development;Devices;Diabetes Mellitus;diabetes self-management;Endocrinologist;Environment;Event;evidence base;experience;Future;Glucose;Goals;group intervention;Health;Health Technology;Hyperglycemia;Hypoglycemia;Impaired cognition;improved;innovation;insight;Insulin-Dependent Diabetes Mellitus;Intervention;intervention program;Interview;K-Series Research Career Programs;Knowledge;Life;Link;Medical emergency;meetings;Mentors;Methods;mHealth;mhealth interventions;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Outcome;patient oriented;Patients;Persons;pilot test;prevent;Prevention;primary outcome;programs;Qualitative Research;randomized trial;Recording of previous events;recruit;Research;research and development;Research Methodology;Research Personnel;Research Project Grants;Resources;Risk;Risk Estimate;Self Management;skill acquisition;skills;Structure;Surveys;System;tailored text messaging;Techniques;Technology;Text Messaging;text messaging intervention;therapy development;Time;time use;Training;Work

PROJECT_TITLE: Minimizing Hypoglycemia in Adults with Type 1 Diabetes through an Integrated Mobile Health and Continuous Glucose Monitoring System

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE  Deciphering the interplay of transcriptional enhancers and gene expression within three-dimensional chromatin architecture is a fundamental challenge in molecular biology, and to answer these questions, minimally-pertubative, localizable tools that enable real-time, high-resolution analysis are needed. The proposed research details a genetically-encodable, photo-controllable tool that can be used to map the molecular interactome of three-dimensional chromatin structures within live cells with high spatiotemporal resolution. Successful completion of the proposed research will uncover causative impacts of higher-order chromosomal architecture on gene regulation, and their role in cancer development and progression.

PI_NAMEs: TAY, NICHOLAS ENG SOON (contact)

PROGRAM_OFFICER_NAME: BROWN, ANISSA F

PROJECT_TERMS: 3-Dimensional;Architecture;Binding;biochemical tools;Biotin;CCCTC-binding factor;Cell Physiology;Cells;Chemicals;ChIP-seq;Chromatin;Chromatin Fiber;Chromatin Interaction Analysis by Paired-End Tag Sequencing;Chromatin Loop;Chromatin Structure;cohesin;Communities;Data;Development;Engineering;Enhancers;Enzymes;Epigenetic Process;Event;experimental study;Gene Expression;Gene Expression Regulation;Genes;Genetic Materials;Genetic Transcription;Genome;Genomics;Guide RNA;High-Throughput Nucleotide Sequencing;holistic approach;insight;interest;irradiation;Knowledge;Label;Maintenance;Malignant Neoplasms;Maps;Methods;Molecular;Molecular Biology;Neighborhoods;Nuclear Proteins;nuclease;Nucleic Acids;Oncogene Activation;optogenetics;Organelles;Photochemistry;Proteins;Proteomics;Proto-Oncogenes;Radial;Reading;Regulation;Research;Resolution;Role;Signal Transduction;Site;spatiotemporal;Specificity;Structure;System;Techniques;Technology;telomere;Time;tool;Validation;Variant;Work

PROJECT_TITLE: New Proximity Labeling Tools for Studying 3D Chromatin Structure and Function


NIH_SPENDING_CATS: Cystic Fibrosis;Infectious Diseases;Lung;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Abnormal mucociliary clearance (MCC) is a critical component of cystic fibrosis (CF) lung disease, especially in the presence of infection with pathogens such as Pseudomonas aeruginosa. Separating the effects of infection and inflammation have been difficult with currently available in vitro model systems. We have recently developed a novel CF rat model that enables the study of mucus in the presence and absence of infection and inflammation, allowing for detailed identification of the underlying mechanism, in a way that is directly relatable to the human phenotypes.

PI_NAMEs: BIRKET, SUSAN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Ablation;Acceleration;Acute;acute infection;Age;Age Months;Agonist;Airway Disease;Airway Fibrosis;airway inflammation;Animal Model;Appearance;Bacteria;Bacterial Infections;Biological Models;Bronchiectasis;Characteristics;Chronic;chronic infection;Chronic Obstructive Pulmonary Disease;Clinical;Clinical Research;Complementary DNA;Cystic Fibrosis;cystic fibrosis airway;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;cytokine;Data;Defect;Disease;Environment;Event;Exhibits;Exposure to;FDA approved;Genomics;Genotype;Gland;Goals;Human;Hydration status;Hyperviscosity;imaging modality;Impairment;improved;In Situ;in vitro Model;Incidence;Infection;Inflammation;Inflammatory;inflammatory marker;innovation;insight;Institution;Interleukin-1 beta;Interruption;Intervention;Laboratories;Link;Long-Term Effects;lung development;Lung Diseases;Lung infections;Modeling;Mucins;muco-obstructive airway diseases;Mucociliary Clearance;Mucous body substance;mucus clearance;neutrophil;Neutrophil Infiltration;novel;novel therapeutics;Obstruction;Optical Coherence Tomography;overexpression;pathogen;Pathology;patient population;Patients;Phenotype;Population;Predisposition;premature;Property;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Pulmonary Cystic Fibrosis;pulmonary function;rat genome;Rattus;Resolution;Role;Secondary to;small molecule;Staphylococcus aureus;Staphylococcus aureus infection;Submucosa;targeted treatment;Testing;therapeutic development;therapeutic target;therapy resistant;Toll-like receptors;tool;Variant;Virus Diseases;Viscosity;VX-770

PROJECT_TITLE: The Role of Airway Mucus in Infection and Inflammation

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PHR: Project Narrative This project seeks to understand how cell metabolism regulates the development, function, and remodeling/reconstruction of stem cell niches in the bone marrow that supports blood cell-forming stem cells. The information gathered will help better understand certain blood diseases involving the bone marrow microenvironment. It will also provide groundwork for improving blood cell regeneration in stem cell transplantation therapy and chemotherapy, which relies on supportive functioning niches in the marrow.

PI_NAMEs: QU, CHENG-KUI  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Address;Adipocytes;Adult;Anatomy;Animals;B-Lymphocytes;Bioenergetics;Birth;Blood;Blood Cells;Bone Marrow;Bone Marrow Involvement;Cell Cycle Arrest;Cell Lineage;cell regeneration;Cell surface;cell type;Cells;Cellular Metabolic Process;chemokine;Chemotactic Factors;chemotherapy;cytokine;Data;Defect;Development;Embryonic Development;extracellular;Failure;Fatty Acids;Fermentation;Fetal Liver;Glucose;Glycolysis;Hematological Disease;Hematology;Hematopoiesis;Hematopoietic;hematopoietic stem cell niche;Hematopoietic stem cells;Hematopoietic System;Homing;Human;Impairment;improved;information gathering;Investigation;Knock-out;Knockout Mice;Knowledge;Limb Bud;Liver;Lymphoid;Maintenance;Marrow;Mediating;Mesenchymal;Metabolic;Metabolic stress;Metabolism;migration;Mitochondria;mitochondrial metabolism;Mitochondrial Proteins;Modeling;Molecular;Mus;Myelogenous;nestin protein;NIH Program Announcements;Osteoblasts;osteoprogenitor cell;oxidation;Oxidative Phosphorylation;Peptides;Perinatal;perinatal development;Phosphatidylinositol Phosphates;Phosphoric Monoester Hydrolases;Play;Population;preconditioning;precursor cell;Process;progenitor;programs;Proteins;PTPRC gene;Pyruvate;reconstruction;Regimen;Regulation;Research;response;Role;Signaling Molecule;stem cell biology;stem cell niche;Stem cell transplant;stem cells;Stress;Stromal Cells;Supporting Cell;Testing;transplantation therapy

PROJECT_TITLE: Metabolic regulation of stem cell niche development and function

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]