ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE/RELEVANCE TO PUBLIC HEALTH Science and medicine have revolutionized our ability to diagnose rare genetic diseases, but patients and their families still have vanishingly limited treatment options. This is because of the challenges in precisely correcting genetic diseases using gene therapies that are both safe and effective. This U19 program seeks to address this vexing gap for four neurological conditions, with the goal of bringing at least one gene-editing therapeutic to the FDA within 5 years. Success in our program could revolutionize treatment for at least one of the conditions we will study and pave the path for the others in the near future.

PI_NAMEs: ARBAB, MANDANA ;GRAY, STEVEN J;LIU, DAVID R;LUTZ, CATHLEEN M (contact);MOURO PINTO, RICARDO

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Address;adenovirus mediated delivery;Animal Model;Area;Ataxia;base;base editing;base editor;Biodistribution;Cells;Central Nervous System Diseases;Childhood;Clinical;clinical diagnostics;Communication;CRISPR/Cas technology;Data;delivery vehicle;Development;Diagnosis;Diagnostic;Disease;DNA Double Strand Break;Dose;Drug Kinetics;Drug Packaging;effective therapy;exome sequencing;Family;Finding by Cause;Friedreich Ataxia;Future;gene replacement;gene therapy;Genes;Genetic;Genetic Diseases;Genome;genome editing;Goals;Health Sciences;High-Throughput Nucleotide Sequencing;human disease;Huntington Disease;immunogenicity;improved;In Vitro;in vivo;Individual;innovation;Investigational Drugs;Investigational New Drug Application;Knowledge;lead candidate;lead optimization;Life;manufacturability;Medical Genetics;Medicine;member;Modeling;Modification;Monitor;mouse model;multidisciplinary;Nervous System;Nervous System Disorder;Neurologic;Neurons;nuclease;Oncogenic;Outcome;Pathway interactions;Patients;pharmacokinetics and pharmacodynamics;Pharmacology Study;Phenotype;Population;Positioning Attribute;postmitotic;pre-clinical;pre-Investigational New Drug meeting;preclinical evaluation;prime editor;Production;programs;Property;Public Health;Rare Diseases;rare genetic disorder;repaired;Reproducibility;Research;Research Personnel;Research Project Grants;Resources;response;Rett Syndrome;Risk;Route;Safety;Scheme;Spinal Muscular Atrophy;success;Technology;Therapeutic;therapeutic candidate;therapeutic genome editing;Therapeutic Index;Tissues;tool;Toxicology;Translating;translational therapeutics;Translations;Treatment Efficacy;Validation;Variant

PROJECT_TITLE: Preclinical Genome Editing for Rare Neurological Diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-G(70)R]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Neurosciences

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

PI_NAMEs: LUTZ, CATHLEEN M (contact)

PROJECT_TERMS: Achievement;Animal Model;Animal Testing;Characteristics;Clinic;Clinical;Collaborations;Communication;Data;Data Collection;data harmonization;data integration;data sharing;Discipline;Ensure;experience;Face;Fostering;Funding;genome editing;Goals;human disease;human model;improved;Institution;Lead;Leadership;Learning;meetings;Monitor;multidisciplinary;Nervous System Disorder;Neurodegenerative Disorders;Phase;pre-clinical;precision genetics;programs;Protocols documentation;Qualifying;Reagent;Reporting;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Schedule;Science;somatic cell gene editing;Structure;success;synergism;tool;Training and Education;Translations;United States National Institutes of Health;Work

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-G]


ADMINISTERING_IC: DE

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Narrative Cleft lip is the 4th most common birth defect in the U.S. and is known to affect annually one in 800 babies worldwide. The Kids First program aims to uncover the etiology of these diseases and foster data sharing within the pediatric research community. We propose to analyze the Structural Variation of the Kids First Orofacial Cleft: African and Asian Ancestry (244 family triads) cohort currently available from the Kids First data portal to improve diagnostic capabilities and therapies for children and their families affected by these conditions. .

PI_NAMEs: BAYARSAIHAN, DASHZEVEG ;BECKER, TIMOTHY JAMES;SHIN, DONG-GUK  (contact)

PROGRAM_OFFICER_NAME: OKI, NOFFISAT

PROJECT_TERMS: Affect;African;African ancestry;Alleles;analysis pipeline;Asian ancestry;Asian population;Base Pairing;Bite;BMP4;Child;Cleft Lip;cohort;Communities;Complement;Congenital Abnormality;Copy Number Polymorphism;Data;Data Analyses;data portal;data resource;Data Set;data sharing;Deposition;Development;Diagnostic;diagnostic value;Disease;DNA sequencing;Enhancers;Etiology;Family;Fostering;Functional impairment;Genes;Genome;genomic data;genomic locus;Genomic Segment;Genomics;Human;Human Genome;Impairment;improved;Individual;Intercistronic Region;Knowledge;Language;Literature;Live Birth;Malignant Childhood Neoplasm;MAPK3 gene;Nucleotides;orofacial cleft;Outcome;paralogous gene;Parents;Pathway Analysis;Pathway interactions;Pediatric Research;phase 3 study;Phenotype;phenotypic data;programs;Publishing;Reporting;Research;Role;Sampling;Structural Congenital Anomalies;Surveys;Therapeutic;transcription factor;Untranslated RNA;Variant;whole genome;Work

PROJECT_TITLE: Structural Variation analysis of Orofacial Cleft associated genomic regions in African and Asian populations


PI_NAMEs: MURRAY, STEPHEN A (contact)

PROJECT_TERMS: adeno-associated viral vector;Animal Model;Animal Testing;Biodistribution;Biological;Biometry;Breeding;Clinic;cohort;Collection;cost effective;CRISPR/Cas technology;Data;design;Disease;disease model;Dose;Drug Kinetics;Evaluation;experience;experimental study;Faculty;Formulation;Funding;Generations;Genes;Genetic Engineering;genome editing;genome editor;Goals;human disease;Human Engineering;human model;improved;In Vitro;in vivo;Individual;Infrastructure;knockout gene;Laboratories;Leadership;Modeling;Molecular;mouse model;Mus;Nervous System Disorder;novel;novel therapeutics;Outcome;Pharmacodynamics;Pharmacology;Phase;Phenotype;pre-clinical;precision genetics;preclinical efficacy;preclinical study;Preclinical Testing;Program Research Project Grants;programs;Rare Diseases;Reporter;Research Personnel;Resources;screening;Services;Site;skills;somatic cell gene editing;Specificity;Structure;System;Technology;Testing;The Jackson Laboratory;therapeutic development;therapeutic genome editing;Time;Tissue Harvesting;Toxicology;translational goal;Validation;validation studies;Viral Vector;Work

PROJECT_TITLE: Preclinical Mouse Model Core


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Prevention

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE Abnormalities in sensory perception are commonly reported alongside with social deficits in a wide range of mental illnesses, most prominently in individuals with autism spectrum disorders (ASD). In this proposal, we will investigate oxytocin signaling as a common neurobiological mechanism that underlies the development of sensory perception and social cognition. The outcome of this proposal will reveal important basic rules for brain circuit development, and will identify early diagnostic markers associated with ASD that can guide novel therapeutics.

PI_NAMEs: CHE, ALICIA YUE (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Acute;Address;Adult;autism spectrum disorder;Behavior;Behavioral;behavioral impairment;behavioral outcome;Brain;cell type;Clinical;clinically relevant;Color;comorbidity;Cues;Data;Development;diagnostic biomarker;Discrimination;Down-Regulation;Early identification;Early Intervention;Electrophysiology (science);experience;Functional disorder;Gene Mutation;Genetic;genetic approach;Goals;Growth;Head;Image;Imaging Techniques;Impairment;in vivo;individuals with autism spectrum disorder;information processing;insight;Interneurons;Knowledge;Life;Link;Measures;Mechanics;Membrane Potentials;Mental disorders;mouse model;Mus;neural correlate;neurobiological mechanism;neuromechanism;Neurons;Neuropeptides;novel;novel therapeutics;Outcome;Oxytocin;Oxytocin Receptor;Pattern;Perception;preference;Process;Prosencephalon;Pyramidal Cells;Receptor Signaling;Reporting;Research;Rest;Risk Factors;Role;Secondary to;Sensory;sensory cortex;Sensory Deprivation;Signal Transduction;social;Social Behavior;social cognition;social communication;social contact;social deficits;Social Functioning;Social Interaction;Somatosensory Cortex;Somatostatin;Structure;Symptoms;Synapses;Synaptic plasticity;Tactile;Testing;Texture;Time;translational impact;two-photon;Vibrissae;Work

PROJECT_TITLE: Neural Mechanisms Linking Sensory Perception and Social Behavior

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


PI_NAMEs: LIU, DAVID R (contact)

PROJECT_TERMS: analysis pipeline;animal tissue;Animals;Archives;base editing;Biological;Biological Assay;Biological Models;candidate identification;Cell Line;Cell Separation;cell type;Cells;Clinic;Complex;Custom;Data;data analysis pipeline;Deaminase;design;detection method;DNA;DNA Double Strand Break;efficacy study;Ensure;Enzymes;Equipment;Event;Future;gene editing technology;Genes;genome editing;genome editor;genome-wide;Genomic DNA;Genomics;Goals;High-Throughput Nucleotide Sequencing;human DNA;In Vitro;in vivo;Individual;Laboratories;Libraries;Mammalian Cell;member;Methods;Monitor;mouse model;Nervous System Disorder;off-target site;Outcome;Play;pre-clinical;prevent;prime editing;Process;Program Efficiency;programs;Recording of previous events;Reporting;Research Project Grants;Ribonucleoproteins;Role;Running;Sampling;Site;success;synergism;Technology;Therapeutic;therapeutic candidate;therapeutic genome editing;therapeutic target;Tissue Sample;Tissues;tool;Validation;vector;Viral Vector

PROJECT_TITLE: Gene Editing Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Fatigue Syndrome (ME/CFS);Emerging Infectious Diseases;Infectious Diseases;Neurosciences

ORG_CITY: Columbus

ORG_DEPT: GENETICS

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Narrative Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex disorder of unknown etiology and there are currently no biomarkers available to identify individuals with ME/CFS or to distinguish various subgroups of patients with ME/CFS. Our studies have demonstrated in a subgroup of patients with ME/CFS that the deoxyuridine triphosphate nucleotidohydrolase (dUTPase) proteins encoded by the human herpesviruses (Epstein-Barr virus & human herpesvirus-6) exert their novel biological effects by acting as a pathogen associated molecular pattern (PAMP) triggering the activation of TLR2 or TLR2/1, which are expressed on numerous cell types, inducing signaling cascades that result in the modulation of pathways involved in immunity, energy production and neuronal function. This multidisciplinary research grant will provide new information on the mechanisms by which the herpesviruses -dUTPases may induce immune dysregulation, post-exertional fatigue and cognitive dysfunction as it relates to ME/CFS, provide potential biomarkers and identify targets that may be used for the development of dUTPase-specific therapeutic agents for a subgroup of patients with ME/CFS.

PI_NAMEs: ARIZA, MARIA-EUGENIA  (contact);WILLIAMS, MARSHALL VANCE

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: activin A;Address;adenylate kinase;Affect;Antibodies;Antibody Response;Antigen-Presenting Cells;Anxiety;Astrocytes;Autoimmune Diseases;Award;B-Lymphocytes;Behavior;Binding;Biological;Biological Markers;Biological Models;Blood - brain barrier anatomy;blood-brain barrier disruption;Brain;Catabolism;Cell Count;Cell Differentiation process;Cell Proliferation;cell type;Cells;cerebral microvasculature;Characteristics;Chronic Fatigue Syndrome;Chronic stress;Cognitive;cognitive function;Complex;cytokine;Data;deoxyuridine triphosphate;design;Development;diagnostic biomarker;Disease;Dopamine;Endogenous Retroviruses;Enzymes;Etiology;Exertion;exosome;Fatigue;Functional disorder;Gene Expression;Genes;Glucose;Grant;Growth;Herpesviridae;HHV-6A;Human;Human Herpesvirus 4;Human Herpesvirus 6;Immune;immune activation;Immune System Diseases;Immunity;Immunoglobulins;immunoregulation;Impaired cognition;In Vitro;in vivo;Individual;Inflammation;Inflammatory;innovation;Interdisciplinary Study;Interferon Type II;interleukin-21;Laboratories;Ligation;Link;lytic replication;Malignant Neoplasms;Mediating;Mediator;Mental Depression;Microglia;Molecular;motor control;Mus;Muscle;Muscle Fibers;Muscular Atrophy;Myeloid Cells;Natural Killer Cells;Neurocognitive;Neuroimmune;neuroinflammation;Neurons;novel;Organ;overexpression;Oxidative Stress;pathogen;Pathway interactions;patient subsets;Patients;Pattern;Peroxisome Proliferator-Activated Receptors;Physiological;Plasma Cells;Plasmablast;potential biomarker;Predisposition;Production;Proliferating;Proteins;prototype;Recycling;Regulation;Reporting;Research Project Grants;Role;Serotonin;Serum;Severities;Severity of illness;Signal Induction;Signal Pathway;Skeletal Muscle;Stress;Structure of germinal center of lymph node;Subgroup;Synaptic plasticity;Testing;Therapeutic;Therapeutic Agents;TLR2 gene;trafficking;Tryptophan;Viral Proteins;Virus

PROJECT_TITLE: Stress effects on virus protein induced inflammation and sickness behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CFS-N(80)S]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Prevention;Women's Health Research

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative / Public Health Relevance Sex hormone altering medications are prescribed to over 40% of American adults, and yet the mental health consequences of sex hormones are still poorly understood. This project will be the largest ever investigation of sex hormone effects on post-traumatic stress disorder (PTSD), depression, and anxiety disorders, and the results of this powerful study design will provide much-needed information relevant to the development of new treatment and prevention strategies. The precision medicine approach used here relies on biomarkers and results will be tailored to individuals.

PI_NAMEs: DUNCAN, LARAMIE  (contact)

PROGRAM_OFFICER_NAME: BORJA, SUSAN EILEEN

PROJECT_TERMS: Adult;Age;American;Animals;Anxiety;Anxiety Disorders;Awareness;biobank;Biological Markers;Budgets;Clinical Treatment;Clinical Trials;Cognitive;Contraceptive Agents;Data;Development;Disease;Drug Prescriptions;Elements;Epidemic;Estradiol;Etiology;Exclusion;experience;Fright;Future;Genetic;Genetic study;genome wide association study;genomic locus;Gonadal Steroid Hormones;Grant;Healthcare;Hereditary Disease;Hormones;Hydrocortisone;Individual;inter-individual variation;Investigation;Knowledge;Learning;Life;Link;loved ones;Machine Learning;Measurement;Measures;Medical;Medical History;men;Menstrual cycle;Menstruation;Mental Depression;Mental disorders;Mental Health;Methods;Military Personnel;military service;Modeling;novel;novel therapeutic intervention;Outcome;Participant;Persons;Pharmaceutical Preparations;Phenotype;Play;Population Heterogeneity;Post-Traumatic Stress Disorders;Postmenopause;precision medicine;Prevalence;Prevention;Prevention strategy;Proxy;psychiatric genomics;Public Health;public health relevance;reproductive;Research;Research Design;Role;Sample Size;Sampling;Sampling Studies;service member;sex;sex as a biological variable;Sex Differences;Techniques;Testing;Testosterone;Time;Trauma;treatment strategy;United States;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: Sex hormones and post-traumatic stress disorder (PTSD)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-K(02)]


PI_NAMEs: GRAY, STEVEN J (contact)

PROJECT_TERMS: adeno-associated viral vector;Adherence;adverse outcome;Attention;base editing;base editor;Biological;Biological Assay;cellular transduction;Cerebrospinal Fluid;Chemistry;Clinical;clinical development;Clinical Protocols;Clinical Research;Clinical Trials;Collaborations;Consumption;Core Facility;cost;Creativeness;Data;delivery vehicle;Dependovirus;design;Disease;drug candidate;Drug Packaging;Electronics;Ensure;expectation;experience;gene editing technology;gene therapy;Genes;genome editing;Goals;good laboratory practice;Immune;Immune system;immunogenic;In Vitro;in vivo;innovation;Intravenous;Investigational Drugs;Investigational New Drug Application;Laboratories;Lead;manufacture;manufacturing systems;Mediating;meetings;member;Methods;Monitor;mouse model;Nervous System Disorder;novel;Outcome;Play;pre-clinical;pre-Investigational New Drug meeting;preclinical study;prime editor;Process;Production;programs;Protocols documentation;Reaction Time;Reagent;Recommendation;Recording of previous events;Reporting;Reproducibility;Research;Research Contracts;Research Design;response;Role;Safety;safety study;Satellite Viruses;Services;success;Technology;Texas;Therapeutic;therapeutic evaluation;Time;timeline;Toxicology;Transgenes;Translation Process;Translations;Universities;vector;Viral Vector;Work;Writing

PROJECT_TITLE: Viral Vector and Regulatory Core


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Genetics

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative: Stress hormones are produced by the adrenal gland and promote systemic inflammation that contribute to cardiovascular and metabolic disease, which are two of the leading causes of morbidity and mortality worldwide. We will address sexual dimorphisms associated with adrenal macrophage development and their contribution to regulating the stress response following acute and chronic challenge models, and predict resident macrophages play a direct role in regulating this response. This study will provide definitive answers to adrenal macrophage ontogeny, onset of sexual dimorphism, heterogeneity, and responses to both acute and chronic stressors, knowledge that is essential for the development of therapeutic approaches to combat features of chronic stress that underlie high risk cardiovascular disease patients.

PI_NAMEs: WILLIAMS, JESSE WARREN (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Acute;Adipose tissue;Adrenal Cortex;Adrenal Glands;Adult;Aldosterone;Animal Model;Anti-Inflammatory Agents;Arterial Fatty Streak;Atherosclerosis;Automobile Driving;biological adaptation to stress;blood glucose regulation;Blood Vessels;Bone Marrow;Cardiovascular Diseases;cardiovascular disorder risk;Castration;Cells;Cholesterol;Chronic;Chronic stress;cofactor;cold stress;cold temperature;combat;Complement;conditional knockout;constitutive expression;Consumption;Corticosterone;cytokine;Cytoplasm;Development;Diet;Disease;Endocrine;Epinephrine;experience;Fatty acid glycerol esters;feeding;Female;fighting;Gene Expression;Genes;Genetic;Gonadal Steroid Hormones;Growth;Health;Heterogeneity;high risk;Homeostasis;hormonal signals;hormone therapy;Hormones;Human;Hypertension;Immune;Immune response;Immune system;Immunity;In Vitro;Inflammation;Inflammatory Response;Knock-out;Knockout Mice;Knowledge;Lipids;Literature;Macrophage;Maintenance;male;Maps;Metabolic Diseases;Modeling;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;new therapeutic target;novel;novel strategies;Organ;Ovariectomy;Patients;Phenotype;Plasma;Play;Population;Production;programs;Proliferating;recruit;response;Role;sensor;Severity of illness;sex;sexual dimorphism;single-cell RNA sequencing;Source;steroid hormone;Steroid Receptors;Steroids;Stress;stressor;System;systemic inflammatory response;Testing;therapeutic development;tissue repair;Tissues;transcriptomics;translational approach;TREM2 gene;uptake;virtual;women versus men;Work

PROJECT_TITLE: Sex and stress hormones control adrenal gland macrophage development and function"

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Infant Mortality;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Spinal Muscular Atrophy

PI_NAMEs: ARBAB, MANDANA  (contact)

PROJECT_TERMS: Acceleration;adverse outcome;Age;Alleles;Animals;base editing;Biodistribution;Cells;Cessation of life;Clinic;Clinical Trials;clinically significant;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Combined Modality Therapy;Communication;Compensation;Data;Dose;efficacy evaluation;efficacy study;Ethnic Population;exon skipping;Exons;Functional impairment;Gene Conversion;gene therapy;Genes;Genetic;Genome;genome editing;Genomics;Goals;In Vitro;in vivo;Industry Standard;Infant Mortality;Investigational Drugs;Investigational New Drug Application;Lead;lead candidate;Length;life span;manufacture;Messenger RNA;Modeling;Modification;Monitor;Motor Neuron Disease;Motor Neurons;mouse model;Mus;neonate;Nervous System Disorder;Nucleotides;Outcome;overexpression;Paralysed;Patients;Pharmacology Study;Pharmacotherapy;Phenotype;Positioning Attribute;pre-clinical;preclinical development;programs;Proteins;Protocols documentation;Publishing;Regulation;Reproducibility;Research Personnel;Research Project Grants;Resources;restoration;RNA Splicing;Route;Safety;Sampling;Scheme;SMN expression;SMN protein (spinal muscular atrophy);SMN1 gene;SMN2 gene;Specificity;Spinal;Spinal Muscular Atrophy;survival motor neuron gene;Testing;Therapeutic;therapeutic genome editing;Tissues;tool;Toxic effect;Toxicology;Translating;treatment optimization;Treatment Protocols;Work

PROJECT_TITLE: Project 1: Therapeutic Gene Editing for Spinal Muscular Atrophy (Trailblazer)


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: ROCHESTER

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Project Narrative Virus infections are tightly linked to the development and exacerbation of allergic diseases, including asthma, allergic rhinitis, and atopic dermatitis. The immune response to virus infections are altered in allergic inflammation, however, little is known about the specific cellular pathways involved. The proposed research investigates how the allergic signals modulate critical antiviral cellular responses, providing potential targets for therapeutic intervention.

PI_NAMEs: ROWE, REGINA KAY (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: airway epithelium;Allergic;allergic airway disease;Allergic Disease;Allergic inflammation;Allergic rhinitis;Anti-viral Response;antiviral immunity;Asthma;Atopic Dermatitis;atopy;Biochemical;Bioinformatics;Biological Response Modifiers;CD4 Positive T Lymphocytes;Cell Fractionation;Cell Physiology;cell type;Cells;Cellular Assay;Childhood;Communicable Diseases;crosslink;cytokine;Cytometry;Development;Disease;Doctor of Medicine;Doctor of Philosophy;economic impact;Exposure to;Extrinsic asthma;Fellowship;Flow Cytometry;Foundations;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Goals;Hantavirus;Health Care Costs;Heterogeneity;Human;human disease;IgE;IgE Receptors;Image Cytometry;imaging approach;Immune;Immune response;Immunology;Impairment;improved;In Vitro;in vivo;Incidence;Individual;Inflammation;Inflammatory;Innate Immune Response;innovation;insight;Interferon Receptor;Interferon Type I;Interferons;Interleukin-10;K-Series Research Career Programs;Knowledge;Link;Mediating;Medical;Medical center;Mentors;Methods;microbial;Microbiology;Molecular;monocyte;Morbidity - disease rate;mouse model;novel therapeutics;pathogen;Pathogenesis;Pathway interactions;Phagocytosis;pharmacologic;Phenotype;Physicians;Postdoctoral Fellow;prevent;Process;Production;professor;Receptor Activation;receptor function;Receptor Signaling;receptor-mediated signaling;recruit;Regulation;Research;Residencies;respiratory infection virus;response;Rhinovirus;Role;Scientist;Serum;Signal Pathway;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;skills;Specialist;System;T-Lymphocyte;targeted treatment;Techniques;Testing;Therapeutic Intervention;Tissues;Training;Transcriptional Regulation;transcriptomics;Translating;type I interferon receptor;Universities;Up-Regulation;Viral;Viral Physiology;virology;Virus;Virus Diseases;Washington;Western Blotting;Work

PROJECT_TITLE: Mechanisms of IgE-mediated regulation of monocyte antiviral response pathways

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

PROJECT_TERMS: 15 year old;Acceleration;adeno-associated viral vector;adenovirus mediated delivery;Adolescent;Adverse event;Affect;Age Years;Alleles;Ataxia;autosome;base editing;base editor;Biodistribution;Biological Models;Capsid;Cardiomyopathies;cell type;Cells;Clinic;Clustered Regularly Interspaced Short Palindromic Repeats;delivery vehicle;design;Diabetes Mellitus;Disease;Disease Progression;Dose;Event;frataxin;Friedreich Ataxia;gene complementation;Gene Expression;gene repression;General Population;Genes;Genome;genome editing;Genomics;Goals;Heart;improved;in vivo;Inherited Spinocerebellar Degenerations;innovation;Interruption;Introns;Investigation;Investigational Drugs;knock-down;Late-Onset Disorder;Lead;lead candidate;Length;Life Expectancy;Mediating;Methods;Modification;mouse model;Mus;Muscle Weakness;Nervous System;Nervous System Disorder;Newborn Infant;Onset of illness;Operative Surgical Procedures;Outcome;overexpression;Pancreas;Pathogenicity;Patients;Phenotype;Physical therapy;pre-clinical;preclinical development;preclinical safety;prime editing;prime editor;protein expression;Proteins;Research Personnel;Resources;Route;Safety;Sensory;Somatic Cell;spasticity;Spinal Ganglia;Symptoms;Technology;Therapeutic;therapeutic development;therapeutic genome editing;Tissues;tool;Toxic effect;transcriptomics;Trinucleotide Repeats;Triplet Multiple Birth;United States;Up-Regulation;vector;Work

PROJECT_TITLE: Project 2: Therapeutic Gene Editing for Friedreich's Ataxia


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Dietary Supplements;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Nutrition;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: Public Health Relevance: Racial disparities persist between blacks and whites for colorectal cancer. Recent evidence suggests that the interaction of the gut microbiota and diet may contribute to disease risk. This study will investigate how the Dietary Approaches to Stop Hypertension (DASH) diet affects the gut microbiota across racial groups, which has the potential provide preliminary evidence for the DASH diet as a viable means for improving the gut microbial environment, thereby lowering CRC risk, across racially diverse populations.

PI_NAMEs: CARSON, TIFFANY LASHAUN (contact)

PROGRAM_OFFICER_NAME: KIM, YOUNG S

PROJECT_TERMS: Acetates;Address;Adult;Affect;American;American diet;arm;Bacteroides;Base Sequence;beta diversity;Bifidobacterium;Bile Acids;biobehavior;Biological Markers;Black Populations;blood pressure reduction;Body Weight decreased;Butyrates;cancer risk;Cardiac health;Cardiovascular Diseases;Categories;Chronic Disease;Clinical;Clostridium;Colorectal Cancer;colorectal cancer risk;colorectal cancer treatment;Consumption;Dairying;DASH diet;Data;Deoxycholic Acid;Diet;Diet Modification;dietary;Dietary Fiber;Dietary Intervention;Dietary Practices;disorder risk;Disparity;DNA Damage;dysbiosis;efficacy testing;Environment;experimental study;Fatty acid glycerol esters;Fatty Acids;feeding;Female;Fiber;Fruit;Fusobacterium;Goals;gut bacteria;gut inflammation;gut microbiota;Health;Health Benefit;health disparity;Health Promotion;Health Status;improved;Incidence;Individual;Inflammation;inflammatory marker;innovation;Interleukin-6;Intervention;Knowledge;Lactobacillus;Lead;Leukocyte L1 Antigen Complex;Link;Literature;Lithocholic Acid;liver inflammation;male;Metabolic;Metagenomics;Microbe;microbial;microbiome;Modification;mortality;Not Hispanic or Latino;nutrition;Obesity;outcome disparities;Participant;Pathogenicity;Persons;Physicians;Physiological;poor health outcome;Population;Population Heterogeneity;Porphyromonas;Prevention approach;Prevention Research;Preventive;Production;Propionates;Public Health;public health relevance;Race;racial difference;racial disparity;racial diversity;racial population;Randomized;Recommendation;recruit;Research;Ribosomal RNA;Risk Factors;Risk Reduction;rRNA Genes;Ruminococcus;Sampling;Scientist;sex;stool sample;Structure;systemic inflammatory response;Taxonomy;Testing;Therapeutic;Time;United States;Vegetables;Volatile Fatty Acids;Work

PROJECT_TITLE: Determining the structural- and functional-level effects of diet-specific interventions on the gut microbiota of a diverse sample of Southern United States adults

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Narrative This application requests continued support of NYU’s training program in environmental and molecular toxicology by supporting the annual stipends and tuition of 6 predoctoral and 3 postdoctoral trainees in Environmental Health Sciences. The mission of this training program is the development of creative and independent research scientists who can address the problems presented by complex exposures to environmental pollutants.

PI_NAMEs: CUDDAPAH, SURESH  (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TITLE: Training Program in Environmental Toxicology


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Congenital Structural Anomalies;Genetics;Neurodegenerative;Neurosciences;Pediatric;Primary Immunodeficiencies;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The goal of this study is to identify early molecular and cellular events that trigger inflammation in the brain. We will investigate the mechanism of how RNA cytotoxicity triggers neuroinflammation. These studies may lead to discovery of new therapeutic targets to treat neuroinflammatory and neurodegenerative disorders.

PI_NAMEs: CHUNG, HACHUNG  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: ADAR1;Affect;Alu Elements;Amyotrophic Lateral Sclerosis;Astrocytes;Autoimmune Diseases;Autoimmunity;autoinflammatory diseases;Binding;Biological;Biology;Brain;brain dysfunction;Cell Death;Cell Differentiation process;cell type;Cells;Cerebrospinal Fluid;Collaborations;cytokine;cytotoxicity;Data Set;Detection;Development;Disease;DNA;dosage;Double-Stranded RNA;Early identification;effective therapy;Elements;Enzymes;Etiology;Event;Exhibits;experience;experimental study;fluorescence imaging;Frontotemporal Dementia;gene product;Genomic approach;Genomics;Goals;Homeostasis;Host Defense Mechanism;Human;human stem cells;IFNAR1 gene;Immune response;immunogenic;Immunology;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;Innate Immune System;innovation;insight;Interferon alpha;Interferon Type I;Interferons;Invaded;Investigation;Knock-out;Laboratories;Left;Life;Ligands;Measures;Mediating;Mental disability;Messenger RNA;microbial;Microglia;Molecular;Motor Neurons;Mutation;nerve stem cell;neural;Neurobiology;Neurodegenerative Disorders;neuroinflammation;Neurologic Dysfunctions;Neurons;new therapeutic target;novel therapeutic intervention;nucleic acid detection;Nucleic Acids;pathogen;Patients;Pattern recognition receptor;physically handicapped;Predisposition;prevent;Primates;Production;pseudotoxoplasmosis syndrome;receptor;Receptor Activation;Repetitive Sequence;Research;RNA;RNA Editing;RNA-Binding Proteins;Role;Serum;Signal Transduction;Source;Specificity;stem cell technology;stem cells;Structure;Symptoms;Techniques;Testing;transcriptome;Type I Interferonopathy;Universities;Viral;viral detection;viral DNA;viral RNA;Virus Diseases

PROJECT_TITLE: Investigation of Self-Nucleic Acids as a Trigger for Neuroinflammation

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Biotechnology;Brain Disorders;Dementia;Gene Therapy;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

PROJECT_TERMS: Acceleration;adeno-associated viral vector;adenovirus mediated delivery;Adolescent;Adverse event;Affect;Alleles;Animal Model;autosome;base editing;base editor;Behavioral;Biodistribution;Biological Models;CAG repeat;Capsid;Cell model;Cells;Central Nervous System;Clinic;Clustered Regularly Interspaced Short Palindromic Repeats;Code;cognitive disability;Corpus striatum structure;Dementia;design;Disease;disease model;disease phenotype;Disease Progression;Dose;effective therapy;Ethnic Population;Event;Exons;Gene Expression;Gene Proteins;Genes;Genome;genome editing;Genomics;Glutamine;Goals;human model;Huntington Disease;Huntington gene;improved;in vivo;Incidence;indexing;innovation;Interruption;Investigation;Investigational Drugs;knock-down;Lead;lead candidate;Life Expectancy;Mediating;Methods;Modification;Motor disability;Movement;Mus;Nervous System Disorder;Neurons;Newborn Infant;Onset of illness;Outcome;Pathogenicity;Patients;Persons;polyglutamine;Population;pre-clinical;preclinical development;preclinical safety;preclinical study;Prevalence;prime editing;prime editor;protein expression;psychiatric disability;Research Personnel;Resources;Route;Safety;Severities;Stretching;Symptoms;Technology;Therapeutic;therapeutic development;therapeutic genome editing;Therapeutic Intervention;Tissues;tool;transcriptomics;Trinucleotide Repeats;Triplet Multiple Birth;vector;Work

PROJECT_TITLE: Project 3: Therapeutic Gene Editing for Huntington's Disease


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Gene Therapy;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Rett Syndrome;Women's Health Research

PROJECT_TERMS: Adopted;Affect;Age;Age Years;Animals;base;base editing;Behavior Therapy;Biological Models;Birth;Breathing;Cell model;Cells;Characteristics;Clinical Trials;Deceleration;design;Disease;Disease Progression;DNA Sequence Alteration;dosage;Dose;effectiveness testing;efficacy evaluation;efficacy study;Engineering;Event;Exons;FDA approved;Female;Fibroblasts;Gait abnormality;Genes;genome editing;Grant;Growth;Hand;Head;Histologic;Human;In Vitro;in vivo;Incidence;Language;Life Expectancy;Link;male;Measurement;Methods;Methyl-CpG-Binding Protein 2;Missense Mutation;Modeling;mouse model;Movement;Mus;Mutation;Nature;Neonatal;Nervous System Disorder;Neurodevelopmental Disorder;Neurologic Deficit;Nonsense Mutation;Outcome;overexpression;Patients;Pharmaceutical Preparations;pre-clinical;pre-IND studies;Preparation;prime editing;Proteins;pup;Rett Syndrome;Safety;safety assessment;Seizures;skills;Sleep disturbances;small molecule;Speech;Stereotyping;success;Technology;Testing;Therapeutic;therapeutic genome editing;timeline;Titrations;tool;Twin Multiple Birth;Variant;Viral;Work;X Chromosome

PROJECT_TITLE: Project 4: Therapeutic Gene Editing for Rett Syndrome


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE One of the most common causes of disability during aging is vascular cognitive impairment and dementia (VCID), triggered by cerebral microbleed formation and other microvascular pathologies. The underlying mechanism includes age-related IGF-1 deficiency, which leads to vascular smooth muscle cell dysfunction, increased blood vessel fragility and development of cerebral microhemorrhages (CMH) in the aging brain. CMH can trigger neuroinflammation and consequent neuronal dysfunction, culminating in cognitive impairment and gait disorders, and understanding this sequence of events is critical for the development of effective therapies.

PI_NAMEs: CONLEY, SHANNON M (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Adoption;Affect;Age;age acceleration;age related;age related decline;Age Years;Age-associated memory impairment;aged;Aging;aging brain;Alzheimer's disease related dementia;Apoptosis;Area;Behavioral;Blood Vessels;Brain;Brain hemorrhage;candidate identification;cell growth;Cell Proliferation;Cells;cerebral microbleeds;cerebrovascular;Cerebrovascular Disorders;Cerebrovascular system;Cerebrum;Characteristics;Chronology;cohort;Coupled;Data;Defect;Development;disability;Disease;effective therapy;Elderly;Equilibrium;Event;Exhibits;Extracellular Matrix;Functional disorder;Gait abnormality;Genetic;Genetic Transcription;Geroscience;Goals;Growth Factor;Health;Health Care Costs;healthspan;Homeostasis;Human;human old age (65+);Hyperplasia;Hypertension;Hypertrophy;IGF1 gene;Impaired cognition;Impairment;in vivo;Incidence;Individual;Inflammation;Inflammatory;innovation;insight;Insulin-Like Growth Factor I;Insulin-Like-Growth Factor I Receptor;Ischemic Stroke;Knock-out;laser capture microdissection;Link;Location;Mediating;microvascular pathology;Modeling;Molecular Profiling;mouse model;neuroinflammation;Neuronal Dysfunction;Neurons;novel;Oxidative Stress;Pathology;Pathway interactions;Phenotype;Physiological;Play;Population;Process;Proliferating;Public Health;Quality of life;Regulation;response;Risk;Risk Factors;Rodent Model;Role;Rupture;senescence;Signal Transduction;single-cell RNA sequencing;Smooth Muscle Myocytes;Somatomedins;Stimulus;Stress;Subgroup;Testing;Therapeutic Intervention;Vascular Cognitive Impairment;vascular cognitive impairment and dementia;Vascular Smooth Muscle;Work

PROJECT_TITLE: The role of IGF-1 signaling in vascular smooth muscle cells in age-related vascular cognitive impairment and dementia

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rare Diseases;Rural Health;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE Human papillomavirus (HPV) infection is the leading cause of more than 36,000 cases of cervical, ano-genital, and oropharyngeal cancers in the United States annually. While multi-valent vaccinations to prevent HPV infections have been available since 2006, uptake of the vaccine is well below national Healthy People 2030 targets; HPV vaccination rates are especially low in rural areas (about 11% lower than in urban areas). PREVENT is a randomized controlled trial of adapted HPV vaccination reminders to address the needs of diverse rural populations.

PI_NAMEs: KEPKA, DEANNA LEE (contact)

PROGRAM_OFFICER_NAME: VANDERPOOL, ROBIN CLINE

PROJECT_TERMS: Address;Adolescent;Adoption;Age;Anogenital cancer;Bundling;Caregivers;Child;Clinic;Clinic Visits;Communication;cost;culturally appropriate intervention;Data;design;Disparity;disparity reduction;Dose;Effectiveness;effectiveness testing;Eligibility Determination;Ensure;ethnic diversity;Evaluation;Face;Hispanic Populations;HPV vaccine acceptance;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;implementation evaluation;implementation facilitators;implementation outcomes;improved;Incidence;Interdisciplinary Study;Intervention;Linguistics;Maintenance;Malignant neoplasm of cervix uteri;Malignant Neoplasms;malignant oropharynx neoplasm;Medical Care Team;Methods;Not Hispanic or Latino;outreach;Parents;Patients;Persons;prevent;primary care practice;Provider;Public Health;public health priorities;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Reminder Systems;Research;Rural;rural area;rural dwellers;rural healthcare;rural Hispanic;rural patients;Rural Population;rural setting;safety net;Series;System;tailored messaging;Telephone;Testing;Text Messaging;Time;Translations;Travel;treatment arm;treatment as usual;United States;urban area;urban disparity;Vaccination;vaccine acceptance;Vaccines

PROJECT_TITLE: PREVENT - Practice-based Approaches to Promote HPV Vaccination

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: COLLEGE STATION

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: TEXAS A&M UNIVERSITY

ORG_STATE: TX

PHR: PUBLIC RELEVANCE STATEMENT This training program builds on a long-standing and successful history of training scientists for careers in toxicology and environmental health at Texas A&M University. We aim to keep our training and research base strong and also provide unique focus on regulatory science, a scientific discipline consisting of the development and application of scientific methods, tools, and approaches that are used to support regulatory and other policy objectives. As the fields of toxicology and environmental health acquire new tools to better detect and characterize human health hazards, our trainees receive a strong, broad background in basic science with opportunities to specialize in research and/or decision-making for protection of public health and the environment.

PI_NAMEs: RUSYN, IVAN  (contact)

PROJECT_TITLE: Regulatory Science in Environmental Health and Toxicology

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(T)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Patient Safety;Physical Activity;Prevention;Social Determinants of Health;Telehealth

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Middle to older aged adults with overweight or obesity and cardiometabolic comorbidities, especially minorities, appear most vulnerable to secondary health effects of the COVID-19 pandemic. To confront this public health crisis, the current Project on EHR-Integrated Lifestyle Interventions for Adults Aged Fifty and Older (PIVOT) aims to expand access to simple, effective lifestyle interventions for weight loss and behavior change using electronic health record systems and wearable devices. This study can enable accelerated deployment of effective digital behavioral health interventions at scale to reduce disease burden in aging adults with lifestyle- related multiple chronic conditions.

PI_NAMEs: KANNAMPALLIL, THOMAS GEORGE;MA, JUN  (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Acceleration;Accelerometer;adaptive intervention;Adopted;Adult;adult obesity;Age;aged;Aging;aging population;base;Behavior;behavior change;behavior measurement;Behavior Therapy;Behavioral;behavioral health intervention;Body mass index;Body Weight Changes;Body Weight decreased;burden of illness;cardiometabolism;care delivery;Characteristics;Chronic;Clinical;clinical predictors;clinically significant;comorbidity;Control Groups;COVID-19 pandemic;COVID-19 pandemic effects;Data;design;Development;diabetes prevention program;digital;digital health;digital healthcare;Effectiveness;effectiveness evaluation;electronic health data;Electronic Health Record;electronic health record system;Equilibrium;experience;Frequencies;Future;Goals;Habits;Health;health care delivery;health disparity;Health system;human old age (65+);Improve Access;Incidence;Individual;individual patient;innovation;Insurance Carriers;Intervention;intervention effect;Life Style;lifestyle intervention;Machine Learning;Measures;middle age;Minority;Modeling;Monitor;Motivation;Multi-Institutional Clinical Trial;multi-site trial;multiple chronic conditions;novel strategies;Obesity;older adult;Outcome;Overweight;pandemic impact;Participant;patient health information;Patient Outcomes Assessments;Patients;Personal Satisfaction;Physical activity;physical inactivity;point of care;pragmatic intervention;predictive modeling;Prevalence;prevent;primary outcome;Problem Solving;programs;psychosocial;Public Health;Quality of life;Randomized;recruit;remote health care;Research;response;Secondary to;Self Direction;Sequential Multiple Assignment Randomized Trial;Sleep;sociodemographics;Spanish;Spanish/English;success;Surveys;Tablets;Target Populations;Techniques;Testing;therapy development;Translational Research;Treatment Efficacy;trial design;Unhealthy Diet;unhealthy lifestyle;United States National Institutes of Health;videoconference;Waiting Lists;wearable device;Weight;Weight Gain;weight loss intervention;wireless;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-C(90)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome

ORG_CITY: SAN FRANCISCO

ORG_DEPT: BIOLOGY

ORG_NAME: SAN FRANCISCO STATE UNIVERSITY

PHR: Conflict over an organism’s phenotype, particularly with respect to growth and behavior, can arise between different genes due to differences in genes’ relatedness to maternal and paternal relatives, conflicts that are predicted to be particularly intense on the X chromosome. Consequent antagonistic regulatory relationships between genes is expected to reduce robustness of regulatory networks. The proposed work will lay the foundations for understanding the health consequences of intragenomic conflict by identifying the consequences of intragenomic conflict for the X chromosome at the level of regulatory networks, X-linked gene transcription, transcriptome and cell type distribution.

PI_NAMEs: ROY, SCOTT  (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: aging related disease;Alleles;autosome;Behavior;Biology;cell type;Cells;Characteristics;Code;Conflict (Psychology);Data;differential expression;Disease;Exhibits;experience;Female;fitness;Foundations;Future;Gene Expression;gene regulatory network;Genes;Genetic Transcription;Genome;genome-wide;Genomic Imprinting;Genomics;Goals;Growth;Health;Human;Human Biology;human disease;human tissue;imprint;Individual;Inheritance Patterns;Inherited;insight;interest;Intervention;Link;link protein;male;Malignant Neoplasms;Mammals;MicroRNAs;Molecular;Molecular and Cellular Biology;Motivation;Noise;Organism;Outcome Study;Parents;Pattern;Phenotype;programs;Proteins;Regulation;Regulator Genes;Research;Research Personnel;Resources;Role;Shapes;Signal Transduction;single-cell RNA sequencing;Source;Testing;Tissues;transcriptome;transcriptome sequencing;transcriptomics;Work;X Chromosome;X Inactivation

PROJECT_TITLE: Competition between maternal and paternal X chromosomes in human biology and cancer


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Climate-Related Exposures and Conditions;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Liver Cancer;Liver Disease;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Nonalcoholic fatty liver disease (NAFLD), the most common cause of chronic liver disease, and hepatocellular carcinoma (HCC), the most common type of primary liver cancer, are increasing in incidence worldwide. Evidence suggests that exposure to fine particulate matter less than 2.5 microns in diameter (PM2.5), a ubiquitous air pollutant, may impact the risk of developing NAFLD and HCC, especially among particular subgroups defined by race/ethnicity, geography, and sex. We propose to investigate the associations between ambient PM2.5 exposure and NAFLD and HCC risk, and the contribution of PM2.5 to NAFLD and HCC incidence disparities, in veterans across the United States, which will help identify individuals at high risk for NAFLD and HCC.

PI_NAMEs: VOPHAM, TRANG  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Address;Affect;Age;Air Pollutants;Air Pollution;Anatomy;Animals;Automobile Driving;Berry;Biometry;Blood Circulation;career development;Censuses;Chemicals;Chronic Hepatitis B;Chronic Hepatitis C;chronic liver disease;Clinical;Collagen;Data;data warehouse;demographics;Deposition;Diabetes Mellitus;Diagnosis;Diameter;disease disparity;disorder risk;Disparity;Dyslipidemias;Electronic Health Record;Ensure;Environment;Environmental Epidemiology;Environmental Exposure;Environmental Risk Factor;Epidemiologist;Epidemiology;epidemiology study;ethnic diversity;Ethnic Origin;Etiology;experience;Exposure to;Fibrosis;fine particles;Fred Hutchinson Cancer Research Center;Future;geographic difference;Geographic Information Systems;Geography;Goals;health disparity;Health Personnel;Healthcare Systems;Hepatitis B Virus;Hepatitis C virus;Hepatology;high risk;Hispanic Populations;Hospitalization;Human;Incidence;Individual;Inflammation;Inhalation;innovation;insight;Interdisciplinary Study;Knowledge;Lead;Link;Lipids;Liver;Liver diseases;Location;Malignant neoplasm of liver;men;Mentors;meter;Methodology;Methods;Midwestern United States;Modeling;Mus;Non obese;non-alcoholic fatty liver disease;non-diabetic;novel;Obesity;oxidative damage;Participant;particle;Particulate Matter;patient population;Patients;Play;Population;Prevention;Primary carcinoma of the liver cells;Primary Malignant Neoplasm of Liver;programs;prospective;Race;racial disparity;racial diversity;regional difference;Research;research and development;Research Personnel;Research Training;Resolution;Resources;respiratory;Risk;Risk Factors;risk perception;Risk Reduction;Role;Science;Scientist;Severity of illness;sex;Sex Differences;Signal Transduction;skills;Small-Area Study;Socioeconomic Status;sound;Source;spatiotemporal;Subgroup;Thinness;Time;Tissues;Training;Training Programs;Transforming Growth Factor beta;translational potential;United States;United States Department of Veterans Affairs;Universities;Veterans;Veterans Health Administration;Washington;Work

PROJECT_TITLE: Air pollution and health disparities in liver disease and cancer

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

ORG_NAME: NEW YORK STRUCTURAL BIOLOGY CENTER

PHR: This proposal describes the need for and outline of an RM1 BTDD Center on Macromolecular Dynamics by NMR Spectroscopy (CoMD/NMR) situated at the New York Structural Biology Center. The focus of CoMD/NMR is to facilitate access to and adoption of cutting-edge technologies of NMR spin relaxation and associated methods for characterizing protein and nucleic acid conformational dynamics in biological processes, emphasizing functional aspects of oligomerization or assembly and of ligand recognition. The objectives of this proposal impact a diverse range of biological research with human health relevance, including cell signaling (in cancer and cell death pathways), degenerative diseases, metabolic disorders, and cancer.

PI_NAMEs: PALMER, ARTHUR G (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Address;Adoption;Automobile Driving;Biological;Biological Process;biological research;Biology;Biomedical Technology;Biophysics;Biopolymers;Catalysis;Cell Death;Chemicals;Collaborations;Communities;community engagement;Community Health Education;Community Outreach;Complex;Computational Technique;Computer software;Computers and Advanced Instrumentation;Computing Methodologies;Coupling;Cryoelectron Microscopy;data acquisition;Data Analyses;Degenerative Disorder;Deposition;Development;Educational workshop;Ensure;Environment;Equipment;experimental analysis;experimental study;Freezing;Future;Geography;Gills;Health;high risk;Human;improved;instrument;instrumentation;International;Investigation;Kinetics;Laboratories;Ligands;Link;macromolecule;magnetic field;Malignant Neoplasms;Measurement;Medical;Membrane Proteins;Metabolic Diseases;Methods;Mission;Modernization;Molecular Conformation;Nature;New York;NMR Spectroscopy;novel;Nuclear;Nucleic Acid Conformation;online tutorial;Pathway interactions;Physiologic pulse;Pilot Projects;pressure;Procedures;Process;Production;program dissemination;programs;Property;Proteins;Protocols documentation;public database;Publications;Qualifying;recruit;Relaxation;Research;Research Personnel;Resolution;Resources;restraint;Rotation;Scientist;Services;Signal Transduction;Site;solid state nuclear magnetic resonance;Specialist;Strategic Planning;structural biology;Structure;symposium;synergism;System;Techniques;Technology;technology development;Technology Transfer;technology validation;Time;Training;Training Activity;web site;Work;X ray diffraction analysis

PROJECT_TITLE: RM1 Center on Macromolecular Dynamics by NMR Spectroscopy at the New York Structural Biology Center (CoMD/NMR)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J(55)R]


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative This application builds on the Duke MSTP's long history of training successful physician- scientists by incorporating a number of major changes and improvements, including: 1) Incorporation of improved medical school and graduate school assessment tools to track and evaluate students' progress throughout their training; 2) Development and incorporation of enhanced opportunities for trainees to influence their own career development; 3) Improvement of the admissions process to ensure holistic review and selection of candidates from diverse backgrounds, including enhanced outreach efforts to candidates from historically underrepresented backgrounds; 4) Enhanced trainee oversight at multiple stages of the program, including an emphasis on identification of roadblocks during annual Individual Development Plan meetings between leadership and students; 5) Broadening of the participating faculty to ensure input from a range of outstanding and diverse faculty at all levels; 6) Creation of additional program activities with guidance from the program's trainees and steering committee to ensure adequate program-wide training opportunities that foster program unity, including enhanced vertical integration through Duke's institution-wide Office of Physician- Scientist Development; and 7) Creation of a Diversity, Equity, and Inclusion committee to enhance program initiatives through which all can experience a true sense of belonging regardless of ethnicity, gender, age, national origin, sexual orientation, religious beliefs, or socioeconomic, veteran, or ability status. Collectively, these new program initiatives will continue the Duke MSTP's longstanding tradition of excellence in MD-PhD training and substantially improve outcomes for the approximately 85-90 students in the program each year.

PI_NAMEs: KONTOS, CHRISTOPHER D (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TITLE: Medical Scientist Training Program Training Grant

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: DA

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Mental Health;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: BRONX

ORG_NAME: FORDHAM UNIVERSITY

PHR: Project Narrative Excessive impulsivity, a hallmark of chronic drug abuse, promotes selection of short-term gains at the expense of long-term goals, like abstaining from drug use or seeking treatment. Developing new solutions to ameliorate drug relapse, therefore, will require a more complete understanding of the brain processes behind impulsive decision making. Here, we will use innovative cell-targeted strategies to uncover the unique roles of cholinergic interneuron D2 dopamine receptors in shaping neuronal signaling and impulsive behavior both in health and after chronic cocaine exposure.

PI_NAMEs: GALLO, EDUARDO FRANCISCO (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Acetylcholine;addiction;Animals;Behavior;Behavioral;Binding;Brain;Brain imaging;cell type;Cells;cholinergic;Chronic;Cocaine;Cocaine Abuse;cocaine exposure;cocaine relapse;cocaine related behaviors;Cues;Data;Decision Making;Development;discounting;Dissection;Dopamine;Dopamine D2 Receptor;dopaminergic neuron;Drug abuse;Drug Addiction;drug of abuse;drug relapse;Drug usage;Female;Fiber;genetic approach;Goals;Health;Human;Impairment;Impulsive Behavior;Impulsivity;in vivo;innovation;Internal Ribosome Entry Site;Interneurons;Knock-out;Knowledge;Lead;Link;Literature;male;Measures;Mediating;Methods;Motivation;Mus;nerve supply;neural circuit;Neurons;neurotransmission;novel;novel therapeutic intervention;Nucleus Accumbens;optogenetics;outcome prediction;Pharmaceutical Preparations;pharmacologic;Phenotype;Photometry;Play;Population;preclinical study;preference;prevent;Process;Psychological reinforcement;radioligand;receptor expression;receptor function;Receptor Gene;Receptor Up-Regulation;receptor upregulation;Relapse;relapse risk;Research;response;Rewards;Rodent;Role;sensor;Shapes;Signal Transduction;Specificity;stimulant exposure;Testing;Therapeutic;Up-Regulation;Viral

PROJECT_TITLE: Cholinergic interneuron D2 receptor function in impulsive behavior: implications for addiction

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: COLUMBIA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Mitochondrial diseases, including Leigh Syndrome, affect 1 in 5000 live births. These studies will determine if the bioenergetic deficit due to impaired mitochondrial Complex I function is exacerbated by defective function of the citric acid cycle. We will determine if alternative metabolite generation facilitates the neuropathological decline. We will also investigate site-specific therapeutic strategies that may be rapidly translatable for humans.

PI_NAMEs: FRIZZELL, NORMA  (contact)

PROJECT_TERMS: Acceleration;Address;Affect;alpha ketoglutarate;Anti-Inflammatory Agents;Ataxia;Basal Ganglia;Biochemical;Bioenergetics;Brain;Brain Stem;Bypass;Cells;Chemicals;Citric Acid Cycle;Clinical;Complex;Cysteine;Data;Defect;demethylation;design;Developmental Delay Disorders;Disease;effective therapy;Encephalopathies;Engineering;Epigenetic Process;Esters;Exhibits;Fumarates;Functional disorder;Generations;Genes;Genetic;Gliosis;Guanosine Triphosphate;histone demethylase;Histone H3;histone methylation;Human;Impairment;individualized medicine;Infiltration;Inflammation;Inflammatory;insight;Ketoglutarate Dehydrogenase Complex;Knock-out;Knockout Mice;Lactic Acidosis;Leigh Disease;Lesion;Life;Link;Live Birth;Lysine;Malate Dehydrogenase;Mediating;Metabolic acidosis;Metabolism;Microglia;Mitochondria;Mitochondrial complex I deficiency;Mitochondrial Diseases;Modeling;Modification;mouse model;Mutation;Neuroglia;neuroinflammation;neuron loss;Neurons;neuropathology;novel;olfactory bulb;Oxidative Phosphorylation;Pathologic;Pathology;Peptides;Permeability;Phagocytes;Phenotype;Phosphorylation;Post-Translational Protein Processing;prevent;Production;Proteins;Reaction;Reporting;Resolution;respiratory;Respiratory Chain;Role;Seizures;Severities;Site;succinyl-coenzyme A;targeted treatment;Therapeutic;transcription regulatory network

PROJECT_TITLE: Investigating Citric Acid Cycle Perturbations in Complex I Deficient Mitochondrial Encephalopathy

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: PROJECT NARRATIVE  A wealth of neuroimaging work indicates cortical-amygdala activity across different networks can provide 'fingerprints' of specific psychiatric disease. Yet understanding of the 'hardwiring' of cortical amygdala microcircuits that underlie these functional data has lagged. We interrogate how cortical nodes frequently implicated in psychiatric disease specifically interface in the amygdala, with the goal of finding specific cellular correlates that may be altered in disease states.

PI_NAMEs: FUDGE, JULIE L. (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Amygdaloid structure;Anatomic Models;Anatomy;Animals;Anterior;Area;associated symptom;Back;behavioral outcome;bodily sensation;Brain;Cells;Cercopithecidae;Conflict (Psychology);Cues;Data;design;Development;Disease;Disparate;Emotional;Equilibrium;experimental study;Feedback;Fingerprint;Functional disorder;Glutamates;Goals;Human;human model;information processing;Injections;Insula of Reil;Label;Maps;Mediating;Mental disorders;Monitor;Monkeys;neuroimaging;Neurons;Output;Pain;Perception;Population;Populations at Risk;Prefrontal Cortex;Primates;Pyramidal Cells;Research;response;segregation;social;social communication;Source;Symptoms;System;Visceral;Work

PROJECT_TITLE: Resolving amygdala microcircuits: implications for function


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative The genomics era was anticipated to bring with it the capacity to use molecular biology tools to identify specific cancer-causing mutations and translate that information into better therapy. This problem has not been realized for most children with cancer, especially diseases like fusion-positive rhabdomyosarcoma (FP-RMS) that harbors few highly recurrent mutations. Our project will develop two new tools – a Bayesian-based, integrative analyses of genomic and epigenetic features of FP-RMS, and FP-RMS PDX models and cell lines where the oncogenic fusion protein can be rapidly and reversibly switched “on” and “off” – which will reveal cancer drivers and tumor suppressors, and how they can be influenced by the fusion protein and, potentially, targeted.

PI_NAMEs: SKAPEK, STEPHEN X (contact);XU, LIN

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: Acetylation;analysis pipeline;Auxins;Bayesian Method;Biological;Biological Assay;Biology;candidate identification;Cell Line;Cell model;Cells;Child;Chimeric Proteins;Clinical Research;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Computational algorithm;computational pipelines;CRISPR/Cas technology;Cultured Cells;Data;Data Set;Disease;disorder risk;DNA sequencing;Engineering;Enhancers;Epigenetic Process;epigenome;Experimental Models;Foundations;FOXO1A gene;Fusion Oncogene Proteins;Future;Gene Dosage;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;Genetic Enhancer Element;genomic tools;Genomics;Goals;high risk;Human;innovation;Institution;International;Knowledge;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;Methylation;Modeling;Molecular;Molecular Biology;Mutation;Neoplastic Cell Transformation;next generation;next generation sequencing;novel;Oncogenic;Outcome;patient derived xenograft model;PAX3 gene;PAX7 gene;Pediatric Oncology Group;Prognostic Marker;promoter;Reagent;Recurrence;Research;Research Project Grants;Rhabdomyosarcoma;small hairpin RNA;Soft tissue sarcoma;Specimen;stem;Subgroup;success;Survivors;System;Talents;Therapeutic;tool;transcriptome sequencing;Translating;Translational Research;tumor;Tumor Suppressor Proteins;Work;young adult

PROJECT_TITLE: Nominating vulnerabilities in fusion oncoprotein-driven rhabdomyosarcoma


NIH_SPENDING_CATS: Biotechnology;Regenerative Medicine

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Project Narrative The NIGMS predoctoral biotechnology training program in Biomolecular and Tissue Engineering at Duke University provides trainees with enhanced classroom, laboratory, and research training in the design, manipulation and quantitative characterization of biomolecules, cells, and tissues with special emphasis on the translation of these technologies and their advancement within the biotechnology industry. Training activities are focused on enhancing and diversifying our biotechnology work force and preparing the next generation of leaders who will pioneer burgeoning new fields such as biologic drug development, tissue engineering, and gene and cell therapy.

PI_NAMEs: GERSBACH, CHARLES A.;SEGURA, TATIANA  (contact)

PROGRAM_OFFICER_NAME: DAVANI, BEHROUS

PROJECT_TITLE: University Training Program in Biomolecular and Tissue Engineering

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Efficient separation, isolation, and enrichment of specific molecules and cells are critical research steps in biol- ogy, biotechnology, and medicine, with each playing an important role in advancing biomedical research. Micro- fluidic devices offer promising solutions that can achieve these steps with precise control, but these technologies are currently limited to small amounts of sample, restricting the amount or rate of processing. In the proposed project, these obstacles are overcome by a new technology platform, based on highly configurable arrays of microfabricated features, that uses sound to move and trap small particles and cells for a wide variety of research applications involving enrichment, isolation, and separation.

PI_NAMEs: MEACHAM, JOHN MARK (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Acceleration;Acoustics;Address;Affinity;Antibodies;antibody conjugate;Architecture;Area;Bacteria;Biocompatible Materials;Biological;Biological Markers;biological systems;Biology;biomaterial compatibility;Biomedical Research;Biotechnology;cancer cell;Cell Line;Cell Separation;Cell Size;cell type;Cells;chemical synthesis;Chemicals;Computer Models;Custom;density;design;Detection;detection sensitivity;Devices;Diameter;Dimensions;Ensure;experimental study;Exposure to;fabrication;flexibility;Fractionation;Gene Expression Profile;Height;Hela Cells;high dimensionality;imaging agent;Immunoassay;improved;Individual;Investigation;Label;Lateral;Legal patent;Length;Location;Magnetism;Malignant Neoplasms;Mammalian Cell;MCF7 cell;Measurement;medical specialties;Medicine;meter;Methods;Microbe;Microbial Biofilms;Microbiology;Microfluidic Microchips;microfluidic technology;Microfluidics;Mission;Modeling;Modification;Monitor;Motion;nanoscale;National Institute of General Medical Sciences;new technology;novel;Operations Research;Outcome;particle;Performance;physical property;Play;Porosity;Process;Property;Proteomics;prototype;Proxy;Reaction;Reagent;real time monitoring;Records;Reproducibility of Results;Research;Research Methodology;Role;Sampling;screening;Series;Shapes;Site-Directed Mutagenesis;sound;Specific qualifier value;Specificity;Structure;success;System;Technology;technology development;technology platform;technology research and development;Time;tool;transcriptomics;Translating;Translations;ultrasound;Validation;Width

PROJECT_TITLE: Acoustic platform for separation, isolation, and enrichment in biomedical research

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Hypertension and chronic kidney disease are long-term consequences following recovery from renal ischemic acute kidney injury and unilateral obstructive uropathy. We will determine the contribution of a novel class of arachidonic acid metabolites, EETs, to the chronic changes in renal hemodynamics, endothelial function, and blood pressure regulation following ischemia reperfusion and ureter obstruction kidney injury. Our expected outcome is that the findings of our project will not only enhance our understanding of the pathophysiological mechanisms whereby renal ischemic injury and ureter obstruction leads to salt-sensitive hypertension and chronic kidney disease but have the potential to lead to new therapeutic treatments.

PI_NAMEs: IMIG, JOHN D (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Acids;Acute;Acute Renal Failure with Renal Papillary Necrosis;analog;Arachidonic Acids;Attenuated;Bilateral;Blood flow;blood pressure reduction;blood pressure regulation;Blood Vessels;Cell Adhesion Molecules;Cell Culture Techniques;Cell Physiology;Chronic;Chronic Kidney Failure;CYP2C19 gene;Cytochrome P450;Data;density;design;Development;Dilator;Endothelial Cells;endothelial dysfunction;Endothelium;epidemiology study;Epoxide hydrolase;Functional disorder;genetic manipulation;glomerular filtration;Glomerular Filtration Rate;Goals;hemodynamics;Hydrolysis;Hypertension;hypertensive;Impairment;improved;Inflammation;inhibitor;Injury;Injury to Kidney;Ischemia;ischemic injury;Kidney;Kidney Calculi;Kidney Diseases;Microcirculation;Modeling;novel;novel therapeutics;Outcome;Outcome Study;Patients;pharmacologic;prevent;protective effect;Recovery;Regenerative capacity;renal artery;Renal Blood Flow;renal ischemia;repaired;Reperfusion Injury;Reperfusion Therapy;response;restoration;Rodent Model;salt sensitive;salt sensitive hypertension;Testing;Therapeutic;Tissues;Tubular formation;Ureteral obstruction;urinary tract obstruction;Vascular Endothelial Cell;Vascular Endothelium;Vasodilation

PROJECT_TITLE: Endothelial Epoxygenase, Kidney Injury, and Blood Pressure Regulation

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE The proposed studies are focused on understanding the role of Solute Carrier Proteins in mast cell function in health and disease. These studies will be relevant for the development of therapeutics to target SLCs to modulate disorders in which mast cells play an active role.

PI_NAMEs: JAMES, RICHARD GOFF;PILIPONSKY, ADRIAN M (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Address;Adhesions;Adjuvant;Affinity;airway hyperresponsiveness;Allergens;Allergic;allergic airway inflammation;Allergic Disease;Allergic inflammation;Amino Acids;Antibodies;Biological;Biological Process;Carrier Proteins;Cell Adhesion;Cell Physiology;Cell Proliferation;Cell Surface Proteins;Cells;Cellular biology;Chimera organism;Complex;CRISPR library;CRISPR screen;Cytoplasmic Granules;Data;Disease;Dose;Effector Cell;Environment;Extracellular Matrix;Future;Goals;granule cell;Health;Homeostasis;Human;IgE;Immune;immunopathology;Impairment;in vivo;Individual;Integrin beta Chains;Integrins;Knowledge;Location;Lung;mast cell;Mediating;Mediator;Membrane Proteins;Modeling;Morphology;mouse model;Mus;novel;Peripheral Blood Mononuclear Cell;pharmacologic;Play;Population;Proliferating;Protein Family;Proteins;Publishing;Pyroglyphidae;reconstitution;Reporting;response;Role;Severities;Signal Transduction;solute;Testing;Therapeutic;therapeutic development

PROJECT_TITLE: Critical role for Solute Carrier Proteins (SLCs) for mast cell function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-B(57)]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Immunotherapy;Kidney Disease;Lupus;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: NARRATIVE Anti-neutrophil cytoplasmic antibody glomerulonephritis (ANCA GN) is a life-threatening disease that results from a “confused” immune system attacking one’s own body. Our current treatment, while successful, suppresses the immune system in a non-specific way leaving patients at risk for serious infections and other complications. Our proposal seeks to develop therapies against specific immune targets halting the disease but leaving protective functions intact.

PI_NAMEs: CIAVATTA, DOMINIC J;FALK, RONALD J (contact);FREE, MEGHAN ;JENNETTE, CHARLES

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: Adaptive Immune System;Agammaglobulinaemia tyrosine kinase;Animal Model;Antibodies;Antineutrophil Cytoplasmic Antibodies;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmune Process;Autoimmune Responses;Autoimmunity;autoreactive B cell;B-Lymphocyte Subsets;B-Lymphocytes;beta-Chemokines;Biology;Cell Adhesion Molecules;Cell Therapy;Cells;cellular engineering;cellular targeting;Certification;chemokine receptor;chimeric antigen receptor T cells;Clinical;Clinical Trials;Complement;Complex;Confusion;Cytoplasm;Data;design;Development;Disabled Persons;Disease;Disease remission;DNA Methylation;Elements;Engineering;Epigenetic Process;Epitope Mapping;Epitopes;experimental study;Foundations;FOXP3 gene;Future;Gene Expression;Genetic Recombination;Genetic Transcription;Glomerulonephritis;Goals;Good Manufacturing Process;granulocyte;Granulomatous disease;Harvest;histone methylation;Immune;Immune system;Immune Targeting;Immunocompetent;immunomodulatory therapies;immunoregulation;Immunosuppressive Agents;Immunotherapy;In Vitro;individual patient;Infection;Injury;innate immune mechanisms;Innate Immune Response;Innate Immune System;Knowledge;Life;lymphocyte function associated antigen;Macrophage-1 Antigen;Mediating;Mediator;Modeling;Molecular;monocyte;mouse model;Mus;neutrophil;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Pathogenesis;Pathogenicity;Patients;Peroxidases;personalized medicine;Population;Population Heterogeneity;pre-clinical;Pre-Clinical Model;Precision therapeutics;Process;Protein Biosynthesis;Protein Tyrosine Kinase;Proteinase 3;Proteins;PRTN3 gene;receptor;Regulatory T-Lymphocyte;response;Risk;RNA Splicing;Role;scalpel;side effect;Signal Pathway;T-Cell Receptor;T-Lymphocyte;targeted treatment;Techniques;Technology;Testing;therapy development;tissue injury;Toxic effect;Transcriptional Regulation;Transplantation;United States Food and Drug Administration;Variant;Vasculitis;Wild Type Mouse;Work;Yeasts

PROJECT_TITLE: Pathobiology of ANCA Glomerulonephritis: Targeting Adaptive and Innate Immune Processes for Precision Therapies

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Clinical Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Organ Transplantation;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Transplantation

ORG_CITY: PHILADELPHIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Ensuring the safety of living kidney donors must remain of primary concern to both individual transplant programs and society, in general. The identification of the APOL1 allele and its impact on the development of kidney disease necessitates the development of additional safeguards for potential donors. This application proposes the formative work needed to develop a decisional support tool for African Americans considering genetic testing for the APOL1 allele in the context of living kidney donation.

PI_NAMEs: GARDINER, HEATHER MARIE (contact)

PROJECT_TERMS: Advocate;Affect;African;African American;African American population;African ancestry;African Trypanosomiasis;Alleles;Apolipoproteins;Attitude;Award;Belief;Benefits and Risks;Cancer Model;Caring;Chronic Kidney Failure;Clinical;clinical decision-making;clinical practice;Communication;Consultations;cost;cultural values;Decision Making;design;Development;End stage renal failure;Ensure;ethnic minority;ethnic minority population;Evaluation;Face;Family;Family member;Feedback;Financial Hardship;Focal and Segmental Glomerulosclerosis;Focus Groups;Genes;genetic testing;genetic variant;Graft Rejection;Group Interviews;Health;HIV;Hypertension;improved;Individual;Intervention;Kidney;Kidney Diseases;Kidney Transplantation;Knowledge;Latinx;Living Donors;living kidney donor;Medical;Medical Care Costs;Methodology;Methods;minority patient;Modification;nephrogenesis;non-diabetic;novel;Outcome;Parasitic infection;Patient Care;Patients;Persons;Phase;point of care;preference;Process;programs;Provider;Quality of life;Randomized Controlled Clinical Trials;randomized controlled design;Recommendation;Research;response;Risk;Safety;Series;shared decision making;Social Workers;Societies;Speed;Standardization;support tools;Surveys;Testing;tool;Transplant Recipients;Transplantation;United States;Variant;willingness;Work

PROJECT_TITLE: Genetic Testing (APOL1) Decisional Support for Potential Living Kidney Donors


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Precision Medicine

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Managing multiple chronic illness is difficult task for everyone and often one size does not fit well. Given the rapid social and technological changes, a comprehensive, structured transdisciplinary approach to research training is becoming particularly important for preparing the next generation of nurse scientists. We propose to create a national model for training nurse scientists who will lead developing personalized intervention for people suffering multiple chronic conditions.

PI_NAMEs: STUIFBERGEN, ALEXA  (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: Intervention;Methodology;multiple chronic conditions;Precision Health;Self Management;Training

PROJECT_TITLE: Precision Health Intervention Methodology Training in Self-Management of Multiple Chronic Conditions


ORG_CITY: RALEIGH

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: NARRATIVE Environmental factors are increasingly recognized as having significant contributions to the health of human populations. Given the breadth of environmental factors and the complexity of this field, it is imperative that we continue to train the next generation of toxicologists/environmental health science (EHS) researchers with the technical, operational and professional skills necessary to conduct high impact EHS research, communicate effectively to a wide variety of audiences, and work as part of multidisciplinary teams to understand how human health is impacted by environmental factors.

PI_NAMEs: KULLMAN, SETH WILLIAM (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TITLE: Molecular Pathways to Pathogenesis in Toxicology


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Chronic Pain;Complementary and Integrative Health;Dietary Supplements;Lymphatic Research;Neurodegenerative;Neurosciences;Nutrition;Pain Research;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects;Sleep Research;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: ROCHESTER

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative The “glymphatic system” is a network of perivascular spaces that function as a waste clearance system, analogous to the peripheral lymphatic system. Reduced glymphatic function has been a hallmark observation in models of age, Alzheimer's disease, diabetes, hypertension, traumatic brain injury, chronic high ethanol intake, chronic unpredictable stress, and, preliminarily, pain. This application aims to define whether glymphatic activity may serve as a target for complementary therapeutic approaches and also as a biomarker establishing the efficacy of alternative medical treatments in a murine model of chronic neuropathic pain.

PI_NAMEs: NEDERGAARD, MAIKEN  (contact)

PROGRAM_OFFICER_NAME: BELFER, INNA

PROJECT_TERMS: Absence of pain sensation;Acupuncture Therapy;Acute Pain;Age;Aging;Alcohol consumption;allodynia;Alzheimer's Disease;Alzheimer's disease model;Analgesics;Anterior;Arousal;Biological Markers;Blood Vessels;Brain;Cardiovascular Diseases;Cardiovascular system;Chronic;chronic neuropathic pain;chronic pain;chronic pain management;chronic pain patient;Chronic stress;cingulate cortex;circadian;Complementary Health;Complementary therapies;cytokine;Data;Diabetes Mellitus;Drainage procedure;efficacy evaluation;Eicosapentaenoic Acid;Exercise;experience;glymphatic clearance;glymphatic flow;glymphatic function;glymphatic system;Goals;Heavy Drinking;Hyperalgesia;Hypersensitivity;Hypertension;Immune system;improved;improvement on sleep;Inflammation;Integrative Medicine;interest;Intervention;Light;Lymphatic clearance;Lymphatic System;Maps;Medical;Melatonin;Metabolic;Metabolic syndrome;Microdialysis;Mind-Body Intervention;mind/body;Modeling;Modernization;mouse model;Mus;Natural Supplement;nerve injury;Neural Pathways;neuronal excitability;Norepinephrine;Omega-3 Fatty Acids;Pain;pain model;pain perception;pain reduction;pain relief;pain sensitivity;painful neuropathy;Pathology;Pathway interactions;patient population;Peripheral;Pharmacology;Phenotype;poor sleep;pre-clinical;Process;Research Personnel;response;Rest;Severities;Sleep;Sleep Deprivation;Sleep disturbances;sleep quality;solute;Stress;System;targeted treatment;Techniques;Temperature;Testing;Therapeutic;Time;Traumatic Brain Injury;treatment effect;Treatment Efficacy;Wakefulness;wasting;Work

PROJECT_TITLE: The glymphatic system at the crossroad of integrative health approaches inchronic pain


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE UNIVERSITY

PHR: Project Narrative  Compromised olfactory function is associated with the aging process, as well as a number of human diseases including Alzheimer’s and Parkinson’s and COVID19. Our incomplete understanding of the brain makes it challenging to comprehend the mechanisms that underlie these sensory and motor deficits or brain disorders. By studying how sensory information is encoded and transformed by processing in the brain, we seek to define these mechanisms, which we hope will lead to strategies to protect against such failures.

PI_NAMEs: STORACE, DOUGLAS ANTHONY (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Address;Affinity;aging process;Alzheimer's Disease;Animals;awake;Behavior;Brain;Brain Diseases;Cells;Chemicals;Code;Color;combinatorial;Complex;COVID-19;Data Set;Dependence;Development;Environment;Exposure to;Failure;Food;Future;Genetic;Glutamates;Goals;human disease;Image;imaging approach;in vivo;Link;Measures;Mediating;Mental disorders;Modeling;motor deficit;Mus;neural;neural circuit;Odorant Receptors;Odors;olfactory bulb;olfactory bulb glomeruli;Olfactory Pathways;olfactory receptor;Olfactory Receptor Neurons;optogenetics;Organism;Output;Parkinson Disease;Partner in relationship;Perception;Physiology;Population;Positioning Attribute;Process;Publishing;receptor;response;Rest;Role;Sensory;Smell Perception;Stimulus;success;Synapses;synaptic depression;Testing;Time;tool;two-photon

PROJECT_TITLE: Understanding functional transformations carried out by the bulb

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_CITY: TORRANCE

ORG_NAME: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER

PHR: NARRATIVE Oral candidiasis, also known as oral thrush, is an AIDS-defining fungal infection of the oral mucosa. This disease also afflicts individuals on chemotherapy, transplant patients taking immunosuppressive drugs, asthma patients using inhaled corticosteroid drugs or others with compromised immune function such as infants and the elderly. The objective of this project is to understand interactions between commensal Candida albicans and the host immune system while the long-term goal of this research is to develop better therapies or vaccines for mucosal disease of the oral cavity, and to understand the consequences of therapies that suppress specific immune events.

PI_NAMEs: SWIDERGALL, MARC  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;acute infection;adaptive immune response;Adrenal Cortex Hormones;angiogenesis;anti-fungal agents;Antigens;Architecture;asthmatic patient;B-Lymphocytes;beta-Glucans;Blood Vessels;Candida;Candida albicans;Cell Proliferation;Cell Wall;Cells;chemotherapy;conditional knockout;cross reactivity;cytokine;Data;Development;Disease;Elderly;Endothelial Cells;Endothelium;Ensure;Epigenetic Process;Epithelial Cells;Epithelium;Event;Exposure to;Fibroblast Growth Factor;Food;fungal microbiota;fungus;Goals;Human;Immune;immune function;Immune response;Immune system;Immunity;Immunologics;Immunosuppression;Immunosuppressive Agents;In Vitro;Individual;Infant;Infection;Inflammation;Inflammatory Response;Inhalation;Innate Immune Response;Integration Host Factors;interleukin-22;Invaded;Knowledge;Life Style;Link;Mediating;Mediator;Memory;Metabolic;microorganism;Modeling;Molecular;mouse model;Mouth Diseases;Mucosal Immune System;Mucosal Immunity;mucosal vaccine;Mucous Membrane;Mus;mycobiome;Mycoses;neutrophil;Oral;Oral candidiasis;Oral cavity;oral cavity epithelium;oral commensal;oral fungal;Oral mucous membrane structure;Organism;oropharyngeal thrush;pathogen;Pathogenicity;Permeability;Pharmaceutical Preparations;Physiology;Play;Predisposition;prevent;Process;Production;Proliferating;receptor;recruit;Reporter;Research;resident commensals;response;Role;Signal Transduction;Source;STAT3 gene;Stimulus;Stromal Cells;Surface;T cell response;T-Lymphocyte;Tissues;Training;Transplant Recipients;vascular contributions;Vascular Endothelial Cell

PROJECT_TITLE: Oral commensal fungi and structural immunity

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE For over three decades the PhD training program in Molecular Pharmacology and Experimental Therapeutics (MPET) in the Mayo Clinic Graduate School of Biomedical Sciences (MCGSBS) has been training outstanding researchers with the interdisciplinary background and skills to make exciting basic research discoveries and then propel these discoveries toward novel therapies for human diseases. We are requesting funding to support a program with a track record of producing outstanding scientists.

PI_NAMEs: CHOI, DOO-SUP  (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TITLE: Predoctoral Training Program in Molecular Pharmacology


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE The overarching goal of the proposed research is to develop a new MRI technology for imaging oxidative stress: hyperpolarized dehydroascorbate (HP DHA) MRI. Oxidative stress is implicated in the pathogenesis of many diseases, including neurodegeneration and brain tumors, and there is an urgent need to develop more sensitive and specific imaging approaches to characterize it. We aim to develop HP DHA MRI and apply it to preclinical models of oxidative stress in the brain and brain tumors as well as optimize it for translation into humans. This work will facilitate future patient-specific treatment planning, as well as earlier assessment of response to therapy and the development of novel experimental strategies for cancer treatment.

PI_NAMEs: KESHARI, KAYVAN R (contact)

PROGRAM_OFFICER_NAME: ZHANG, HUIMING

PROJECT_TERMS: Acute;Address;Aging;Animal Model;Antioxidants;ascorbate;Ascorbic Acid;Biochemical Reaction;Biomedical Engineering;Blood - brain barrier anatomy;blood-brain barrier crossing;Brain;Brain Neoplasms;brain tumor imaging;Cancer Biology;cancer therapy;Cell Death;Cells;Cellular Stress;Chemicals;Chemotherapy and/or radiation;Clinical;clinical translation;Data;dehydroascorbate;design;Detection;Development;Disease;DNA Damage;docosahexaenoylascorbic acid;Dose;Environment;Equilibrium;experience;Face;Feasibility Studies;first-in-human;Foundations;Future;Generations;Glycolysis;Goals;Homeostasis;Human;human imaging;Image;imaging approach;imaging modality;Imaging technology;In Vitro;in vivo;individualized medicine;innovation;Isotopes;Learning;Liquid substance;Magnetic Resonance;Magnetic Resonance Imaging;Malignant Neoplasms;Measurement;Measures;Metabolic;metabolic abnormality assessment;metabolic imaging;Metabolic Pathway;Metabolism;Methods;molecular imaging;Molecular Probes;Monitor;Motivation;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;non-invasive imaging;non-invasive monitor;novel;novel strategies;Oxidants;oxidation;Oxidation-Reduction;Oxidative Stress;Pathogenesis;Pathology;Patients;Physical Chemistry;Play;Pre-Clinical Model;preclinical study;Process;Pyruvate;Radiation;Radiation therapy;Reactive Oxygen Species;Relaxation;Research;Research Proposals;Role;Signal Transduction;Signaling Molecule;small molecule;Solid;spectroscopic imaging;standard of care;System;Therapeutic;Time;Tissues;Toxicology;Translating;translation to humans;Translations;Transport Process;treatment planning;treatment response;Visualization;Work

PROJECT_TITLE: Visualizing oxidative stress using hyperpolarized magnetic resonance

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative The mission of the VCU MARC program is to increase the number of students from UR populations who succeed in Ph.D. or MD/Ph.D. level training in the Biomedical or Behavioral Sciences. Our overarching goal is to create a diverse community of like-minded peers who are confident, academically strong, and have advanced research skills. These ethical and rigorously trained young scientists will be the leaders of the scientific workforce of the future, prepared to strive to eradicate health disparities and advance scientific innovation.

PI_NAMEs: ESCALANTE, CARLOS R;GOLDING, SARAH ELIZABETH (contact)

PROJECT_TERMS: African American population;Awareness;Bioinformatics;Biological Sciences;Biology;Biomedical Engineering;Biomedical Research;career;career development;career networking;Chemicals;Chemistry;Classification;college;Communities;design;Doctor of Philosophy;Engineering;Enrollment;Ethics;evidence base;Expenditure;experience;Exposure to;Faculty;Goals;Graduate Education;health disparity;innovation;Institution;K-Series Research Career Programs;Kinesiology;Mentorship;Mind;Mission;National Institute of General Medical Sciences;next generation;Outcome;peer;Physics;Population;Preparation;Program Development;programs;Psychology;Reproducibility;Research;Research Activity;Safety;Schools;Science;Scientist;Self Efficacy;skills;Strategic Planning;Students;Training;Training Programs;undergraduate education;undergraduate student;United States National Institutes of Health;Universities;Virginia

PROJECT_TITLE: Virginia Commonwealth University Maximizing Access to Research Careers (VCU MARC)

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Brain Disorders;Cannabinoid Research;Endocannabinoid System Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Therapeutic Cannabinoid Research;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: AUGUSTA

ORG_DEPT: NEUROSURGERY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Traumatic brain injury (TBI), a leading cause of mortality and long-term disability worldwide, is a significant public health issue, debilitating or killing more individuals that breast cancer, AIDS, multiple sclerosis, and spinal cord injury combined. In this project, we will implicate the modulation of MAGL-CB2R-TLR4 axis in myeloid cells in the attenuation of the secondary neurovascular injury after TBI. Our conceptually and technically innovative studies will establish a mechanistic framework for the development of novel therapeutic approaches and will identify a potential biomarker to prospectively identify patients at high risk for neurological deterioration.

PI_NAMEs: VAIBHAV, KUMAR  (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: 2-arachidonylglycerol;Acquired Immunodeficiency Syndrome;Acute;Adoptive Transfer;Advanced Development;anandamide;arachidonate;Attenuated;attenuation;Behavioral;behavioral outcome;Brain Injuries;cannabinoid receptor;Cells;Cellular Immunity;central nervous system injury;Cerebral Edema;Cerebrovascular Circulation;Chronic;Clinical;CNR1 gene;CNR2 gene;Core-Binding Factor;Deterioration;Development;disability;Edema;Endocannabinoids;endogenous cannabinoid system;Enzymes;Equilibrium;excitotoxicity;Functional disorder;Genetic;Gliosis;Glycerol;Goals;Health;Helper-Inducer T-Lymphocyte;high risk;Hour;Human;Immune;immune activation;immune modulating agents;Impairment;improved;Individual;Infiltration;Inflammation;Inflammatory;Injury;innovation;Ligands;Lipids;Long term disability;Lymphoid;Macrophage;Malignant Breast Neoplasm;Mechanics;Medical Care Costs;Microglia;Molecular;Monoacylglycerol Lipases;Monoglycerides;mortality;Multiple Sclerosis;Mutant Strains Mice;Myelogenous;Myeloid Cells;Nerve Degeneration;neuroinflammation;Neurologic;neuron loss;neurovascular;neurovascular injury;Nonesterified Fatty Acids;novel;novel strategies;novel therapeutic intervention;Outcome;Patient-Focused Outcomes;Patients;pharmacologic;Phenotype;potential biomarker;Productivity;prospective;protective effect;Public Health;Regulation;Reporting;Resolution;Role;Spinal cord injury;T-Lymphocyte;TBI Patients;Testing;therapeutic target;TLR4 gene;Trauma;Traumatic Brain Injury;vasoconstriction;white matter injury

PROJECT_TITLE: Therapeutic Targeting of Monoacylglycerol Lipase After Traumatic Brain Injury

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]