NIH_SPENDING_CATS: Cardiovascular;Congenital Structural Anomalies;Heart Disease;Heart Disease - Coronary Heart Disease;Lymphatic Research;Pediatric;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Characterizing how LECs participate in embryonic organ growth is will provide new clues about the functional roles of lymphatics in this process. Determining how cardiac lymphatic vessels in general, and Reelin in particular contribute to enhanced cardio-protection after MI could lead to the development of novel therapies for the alleviation of several cardiac pathological conditions. This knowledge could also lead to the use of novel diagnostic tools to help identify lymphatic associated cardiac anomalies.

PI_NAMEs: OLIVER, GUILLERMO C (contact)

PROJECT_TERMS: Acute myocardial infarction;Adult;Animal Model;Apoptosis;Area;Biology;Blood;Blood Vessels;Cardiac;Cardiac Edema;Cardiac Myocytes;cardiac regeneration;cardiac repair;cardiogenesis;cardioprotection;Cell secretion;Cells;Cicatrix;Communication;Conditioned Culture Media;Development;diagnostic tool;Embryo;Endothelial Cells;Exhibits;Foundations;gain of function;Genetic Transcription;Goals;Growth;Growth Factor;Heart;Heart Abnormalities;heart dimension/size;Heart Diseases;heart function;Heart Injuries;Homeostasis;Human;human induced pluripotent stem cells;immune clearance;improved;induced pluripotent stem cell derived cardiomyocytes;Infarction;injured;Injury;insight;Knockout Mice;Knowledge;Laboratories;lymph flow;Lymphangiogenesis;Lymphatic;Lymphatic Endothelial Cells;lymphatic vasculature;lymphatic vessel;Mammals;Mass Spectrum Analysis;Mediating;Modeling;Molecular;Morphology;mortality;mouse model;Mus;mutant;Myocardial Infarction;Necrosis;novel;novel diagnostics;novel therapeutics;Nutrient;Organ;organ growth;organ regeneration;Organogenesis;Oxygen;paracrine;Paracrine Communication;Pathologic;Pathway interactions;Play;prevent;Prevention;Process;Production;Proliferating;protective factors;regenerative;Regulation;Reporting;Research;Resources;Rodent;Role;Route;Signal Transduction;Therapeutic;therapeutic target;tissue repair;Tissues;tool;transcription factor;transcriptome sequencing;Vascular Endothelial Growth Factor C;Western World;Work;Zebrafish

PROJECT_TITLE: Functional roles of lymphatics in organogenesis and tissue repair

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Orphan Drug;Pediatric;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: MORGANTOWN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: PUBLIC HEALTH STATEMENT/PROJECT NARRATIVE The proposed research is relevant to public health because pertussis causes potentially deadly respiratory infections in children. Pertussis strains are circulating due to waning immunity of DTaP/Tdap vaccines as well as vaccine pressure. The re-emergence of pertussis indicates a critical need to develop new vaccine strategies, thus, the proposed research is relevant to NIH’s mission regarding enhancing health, lengthening life, and reducing illness.

PI_NAMEs: DAMRON, FREDRICK HEATH (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: 11 year old;Acellular Vaccines;Adjuvant;Adolescent;Adult;age group;Antibodies;Antibody Formation;Antibody Response;Antibody-mediated protection;antigen binding;Antigen Targeting;Antigens;Avidity;Bacterial Vaccines;Belgium;Biological Assay;booster vaccine;Bordetella;Bordetella pertussis;Cells;Cellular Immunity;Child;clinical development;clinical efficacy;clinical predictors;Clinical Trials;Collaborations;Complex;Coughing;COVID-19 pandemic;Data;Development;Diphtheria;Diphtheria-Tetanus-acellular Pertussis Vaccines;Disease;Dose;efficacy study;epidemiology study;Evaluation;experimental study;flexibility;Formulation;Generations;Goals;Health;Hemagglutinin;Human;human pathogen;Immune response;Immunity;Immunize;immunogenicity;Immunologic Memory;Immunologics;in vivo;Incidence;Infant;Inflammation;interest;International;Intramuscular;Laboratories;Lead;Leukocytosis;Licensing;Life;lipid nanoparticle;Longevity;Manufacturer;Mediating;Membrane;Messenger RNA;Mission;Modeling;Molecular Conformation;mouse model;Mus;neutralizing antibody;novel;novel vaccines;Papio;pathogen;pertactin;Pertussis;Pertussis Toxin;Pertussis Vaccine;Phenotype;Population;Pre-Clinical Model;pressure;Production;protein expression;protein purification;Protein Subunits;Proteins;Public Health;Rattus;Research;Respiratory Disease;Respiratory physiology;Respiratory System;Respiratory Tract Infections;response;RNA vaccine;Schedule;Scientist;screening;Speed;study population;Subunit Vaccines;Surrogate Endpoint;symposium;Technology;technology platform;Tetanus;Toxin;United States National Institutes of Health;vaccine candidate;vaccine development;vaccine platform;Vaccine Production;vaccine strategy;Vaccines;Virulence Factors;Whole Body Plethysmography;Whole Cell Vaccine

PROJECT_TITLE: Development of mRNA-platform vaccines

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Aging;American Indian or Alaska Native;Arctic;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Hypertension;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stroke

ORG_CITY: PORTLAND

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative The long-term goal of the proposed research is to reduce the incidence of stroke, a health disparity in Yup'ik Alaska Native people, by gaining an understanding of how indigenous cultural values, beliefs, and behaviors result in resilience in responding to chronic stress associated with historical trauma, cultural change and adverse socioeconomic conditions. Understanding the biological processes underlying those protective social factors and their impact on chronic stressor-induced disease provides insight into the steps necessary to reduce not only the risk of stroke, the focus of the proposed research, but also other health disparities in minority populations.

PI_NAMEs: BOYER, BERT BRANDON (contact);DOMBROWSKI, KIRK

PROGRAM_OFFICER_NAME: MARTIN, IMAN

PROJECT_TERMS: Acculturation;Address;Adherence;Alaska Native;Alaska Native population;Alcohol consumption;allostatic load;American Indian Population;Animals;Behavior;Behavioral;Belief;Biological;Biological Aging;Biological Process;Blood Pressure;blood pressure regulation;Buffers;C-reactive protein;Cardiovascular Diseases;Chronic;Chronic stress;coping;cultural values;Data Reporting;decrease resilience;Development;Disease;disorder risk;Disparity;DNA Methylation;Economic Conditions;effective intervention;environmental stressor;Epigenetic Process;epigenome;Ethnic Population;Event;Exercise;Exhibits;fasting plasma glucose;Functional disorder;Gene Expression;genome wide methylation;Glucocorticoids;Glycosylated hemoglobin A;Goals;Health;Health behavior;health disparity;Health Promotion;High Density Lipoprotein Cholesterol;Human;Hydrocortisone;Hyperphagia;Hypertension;improved;Indigenous;Individual;Inflammation;insight;Interleukin-6;Ischemic Stroke;LDL Cholesterol Lipoproteins;Length;Leukocytes;Life Style;Link;Lipids;Maintenance;maladaptive behavior;Mediating;Metabolic dysfunction;Methylation;methylation pattern;Minority Groups;Mitochondria;Modeling;Modification;Molecular;Not Hispanic or Latino;Obesity;Organ;Outcome Measure;Outcome Study;Participant;Patient Self-Report;Persons;Plasma;poor sleep;Population;premature;Prevalence;prevent;promote resilience;protective effect;Psychological Stress;racial population;Reporting;Research;resilience;response;Risk;Risk Factors;Role;Salivary;Site;Smoking;social factors;social health determinants;social stressor;socioeconomics;Source;Stress;Stressful Event;stressor;Stroke;stroke incidence;stroke risk;telomere;Telomere Shortening;Testing;Tobacco use;Trauma;Triglycerides;Yup'ik

PROJECT_TITLE: The impact of enculturation on the epigenetic relationship between chronic stress and hypertension in Yup'ik Alaska Native people

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-F(55)R]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: PACIFIC NORTHWEST RESEARCH INSTITUTE

ORG_STATE: WA

PHR: NARRATIVE (Public Health Relevance): Acute myeloid leukemia (AML) is a serious disease characterized by massive proliferation of disseminated cancer cells throughout the body, including engraftment into solid tissues. We will investigate the unique bivalve transmissible neoplasia model of AML, in which wild populations of clams appear to have evolved a block to cancer engraftment and growth. By comparing how the host cells interact with cancer in cases in which the cancer survives and in cases in which the host can control and reject the cancer, we will understand new mechanisms for the control of cancer which could lead to completely new strategies to treat cancer.

PI_NAMEs: METZGER, MICHAEL JEFFREY (contact)

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: Acute Myelocytic Leukemia;Alleles;Animal Model;Animals;Biological Models;Bivalvia;blocking factor;cancer cell;Cancer Control;Cancer Model;cancer regression;cancer survival;cancer therapy;Cell Communication;Cells;Cessation of life;Circulation;Clams;Clinical;comparison control;Data;Disease;Disease remission;Disseminated Malignant Neoplasm;Distant;DNA;Engraftment;Environment;Exposure to;Gene Expression;Gene Expression Profile;Genes;Genomic DNA;Genomic Segment;Granulocytic Sarcoma;Growth;Hemocytes;Host resistance;Human;Immune response;Injections;Integration Host Factors;Kinetics;Leukemic Cell;Liquid substance;Location;Maine;Malignant Neoplasms;Measures;Methods;Modeling;Nature;Neoplasm Metastasis;Neoplasms;novel therapeutic intervention;Pathway interactions;Pattern;Population;Predisposition;pressure;prevent;Productivity;Proliferating;public health relevance;Reporting;Resistance;Resistance to infection;response;Route;Sampling;Site;Solid;System;Testing;Time;Tissues;transcriptomics;Translating;transmission process;Travel;treatment strategy;tumor;tumor microenvironment;tumor progression;Water

PROJECT_TITLE: Identifying host factors that block engraftment and progression of transmissible cancer as a model of AML

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Dietary Supplements;Infectious Diseases;Lung;Nutrition;Pneumonia;Pneumonia and Influenza;Prevention

ORG_CITY: OMAHA

ORG_DEPT: OTHER CLINICAL SCIENCES

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: The proposed research is relevant to public health because the discovery of novel dietary and genetic factors that increase susceptibility to bacterial pneumonia will ultimately increase our ability to identify and treat vulnerable populations. This is important because bacterial pneumonia effects millions worldwide and can be devastating causing substantial suffering and death. Thus, the proposed research is relevant to the NIH mission to develop fundamental knowledge that will help to reduce the burdens of human disability.

PI_NAMEs: KNOELL, DAREN LEE (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: adaptive immune response;Adaptive Immune System;Alveolar Macrophages;Bacteria;Bacterial Infections;Bacterial Pneumonia;Cell Count;Cell Lineage;Cell Physiology;Cessation of life;Communication;community acquired pneumonia;cytokine;Data;Dendritic Cells;dietary;Dietary intake;dietary restriction;disability;Disease;Disease susceptibility;Equilibrium;experience;Exposure to;Functional disorder;Genetic;genetic variant;Goals;Homeostasis;Hospitalization;Host Defense;Hour;Human;Immune;immune function;Immune response;Immune System Diseases;Impairment;improved;in vivo;Incidence;Infection;Inflammation;Injury;Innate Immune Response;Innate Immune System;Intake;Intracellular Transport;Invaded;Investigation;Knockout Mice;Knowledge;loss of function;Lung;lung injury;Macrophage;Mammals;Mediating;Micronutrients;Mission;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Myelogenous;Myeloid Cell Activation;Myeloid Cells;neutrophil;novel;novel strategies;Outcome;pathogen;Pathogenesis;Pathway interactions;Phagocytosis;Pilot Projects;Play;Pneumococcal Infections;Pneumococcal Pneumonia;Pneumonia;Predisposition;prevent;Production;programs;Public Health;Publishing;Pulmonary Inflammation;Recovery;Research;response;risk variant;Role;Signal Pathway;Streptococcus pneumoniae;Structure of parenchyma of lung;surveillance strategy;T-Lymphocyte;Testing;Time;treatment strategy;United States National Institutes of Health;uptake;Vulnerable Populations;Work;Zinc;Zinc deficiency;Zinc supplementation;zinc-binding protein;ZIP protein

PROJECT_TITLE: Defective Zn Homeostasis impairs host defense against pneumococcal pneumonia

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Older minorities bear a substantial burden of multiple chronic conditions (MCC) and receive poorer quality of chronic disease management. Patient-clinician communication barriers are important contributors to disparities in care and outcomes of MCC. The overarching goal of this proposal is to better understand and overcome disparities in patient-clinician communication among older minorities with MCC by developing a patient- centered technology-based patient-clinician communication intervention called Photo+Care.

PI_NAMEs: JIH, JANE  (contact)

PROGRAM_OFFICER_NAME: WHITE, DOLLY PENN

PROJECT_TERMS: 2 arm randomized control trial;acceptability and feasibility;Address;Adult;Affect;African American;Aging;Aleurites;Area;arm;Asian;Asian Americans;Award;career;career development;Caring;Cellular Phone;Chinese;Chronic Disease;Clinic;Clinic Visits;Clinical;Communication;Communication Barriers;comorbidity;contextual factors;design;Development Plans;Diabetes Mellitus;Diet;Diet Habits;Disease Management;Disparity;enhancing factor;ethnic minority;experience;fall risk;Feedback;Glucose;Goals;Health;health care disparity;health disparity;health equity;Health system;human centered design;human old age (65+);implementation science;improved;improved outcome;Individual;Intervention;Knowledge;Latino;Linguistics;Lived experience;member;Mentors;Minority;Mission;multi-ethnic;multi-site trial;multidisciplinary;multiple chronic conditions;Non-Insulin-Dependent Diabetes Mellitus;older adult;older patient;Outcome;Participant;participant retention;patient oriented;Patient-Centered Care;patient-clinician communication;Patients;Persons;Pharmaceutical Preparations;Population;Primary Care;primary care clinic;primary care setting;Procedures;Protocols documentation;racial minority;Randomized;recruit;Research;Research Personnel;Self Management;skills;Social support;Standardization;Structure;Technology;Testing;tool;Training;usability;Visit;Work;World Health Organization

PROJECT_TITLE: Addressing Contextual Factors in Chronic Disease Management in Minority Older Adults through Photo-based Patient-Clinician Communication


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: PROVIDENCE

ORG_DEPT: BIOLOGY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE. A fundamental goal of evolutionary and biomedical studies of human genomes is to determine the genetic basis of human traits and diseases. The proposed research is relevant to public health because the new methods developed here will be applied to large-scale genomic datasets to infer the evolutionary processes, mutations and genetic pathways that underly human adaptation and disease. Thus, the proposed research is relevant to the part of NIH's mission pertaining to developing fundamental knowledge that will enhance health.

PI_NAMEs: RAMACHANDRAN, SOHINI  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Bayesian Analysis;biobank;Biological;candidate identification;Computing Methodologies;cost;Data Set;Disease;Evolution;Genes;Genetic;genetic architecture;Genetic Variation;Genome Scan;genomic data;Genomics;Goals;Health;Human;Human Genetics;Human Genome;human population genetics;Individual;insight;Investments;Knowledge;Maps;Methods;Mission;multi-ethnic;Mutation;Natural Selections;novel;Outcomes Research;Pathway interactions;Pattern;Phenotype;Play;Population;Population Dynamics;Population Genetics;Process;programs;Public Health;Recording of previous events;Research;Role;Sampling;Series;Shapes;Slide;Statistical Methods;theories;trait;United States National Institutes of Health;whole genome

PROJECT_TITLE: Novel population-genetic methods for localizing targets of natural selection in diverse human genomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Nutrition

ORG_CITY: BIRMINGHAM

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Vitamin D deficiency is estimated to affect over 1 billion people worldwide and is considered a global health crisis, as low vitamin D has been associated with numerous disorders, including immune-mediated diseases, such as IBD. IBD pathogenesis is characterized by dysregulated, proinflammatory T cell responses, which vitamin D treatment appears to down-modulate in favor of an immunotolerant response. In this proposal, we will define mechanisms by which vitamin D impairs immunopathogenic T-cell responses to protect against IBD.

PI_NAMEs: FREY, BLAKE  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: adaptive immunity;Affect;Attention;Binding;Binding Sites;Bioinformatics;bone health;Calcium;career;CD4 Positive T Lymphocytes;Cells;Cholesterol;Clinic;Clinical;Clinical Trials;clinically relevant;Colitis;Collaborations;Competence;conditional knockout;cytokine;Data;Development;dietary;differential expression;Disease;DNA Binding;Enhancers;Environmental Risk Factor;experience;Feedback;Foundations;gastrointestinal;gene repression;Gene Targeting;Genes;Genome;genome wide association study;genome-wide analysis;genomic locus;Genomics;global health;Goals;Health;Heterogeneity;Homeostasis;Hormones;IL17 gene;IL6 gene;Immune;immune function;Immune Tolerance;Immunogenetics;Impairment;improved;Incidence;Industrialization;Inflammation;Inflammatory;Inflammatory Bowel Diseases;insight;Interleukin-10;interleukin-10 receptor;Interleukins;Intestines;IRF4 gene;Kinetics;Life Style;Ligand Binding;Ligand Binding Domain;Ligands;Link;Mediating;Mentors;Molecular;mouse model;Mucous Membrane;murine colitis;Mus;novel;Nuclear Receptors;Oral;Orphan;Pathogenesis;Pathogenicity;Pathway interactions;Patient Care;Patients;Persons;Physicians;Play;Population;Predisposition;prevent;Process;Production;programs;receptor;receptor binding;receptor expression;receptor function;Receptor Signaling;recruit;Reporter;Reporting;Research;response;responsible research conduct;restraint;risk variant;Role;RXR;Scientist;Signal Transduction;Site;skills;small molecule inhibitor;Societies;solar radiation;Source;Specific qualifier value;STAT3 gene;T cell response;T-Lymphocyte;Techniques;Testing;Therapeutic;Training;training opportunity;transcription factor;Transgenic Model;Ultraviolet B Radiation;Vitamin D;Vitamin D Deficiency;Vitamin D3 Receptor;Writing

PROJECT_TITLE: Control of Colitogenic Th17 cells by Vitamin D Receptor Signaling


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease;Microbiome;Nutrition

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE The microbiome field has traditionally studied gut bacteria at the level of species and has identified species- level alterations that are associated with disease. However, no study has found a common pattern of changes that cause disease. Since different bacterial strains can vary in their disease-causing capacity, this project aims to understand the structure of the microbiome at the strain level to identify changes in the microbiome that cause disease and can be targets for treatment.

PI_NAMEs: CHEN-LIAW, ALICE YULAN (contact)

PROJECT_TERMS: Address;Affect;Algorithms;Architecture;Bacterial Genome;Bacteroides fragilis;Clostridium difficile;Colitis;commensal bacteria;Communities;Crohn's disease;Cross-Sectional Studies;Culture Techniques;Diet;Disease;dysbiosis;fecal transplantation;Feces;Functional disorder;Genome;genome sequencing;Genomics;Gnotobiotic;gut bacteria;gut colonization;gut microbiome;gut microbiota;Health;Human;Immune;Individual;Infection;Inflammatory;Inflammatory Bowel Diseases;Investigation;Learning;Measures;Mediating;Metagenomics;Methods;microbial;microbial colonization;microbiome;microbiome alteration;microbiome composition;microbiota;microorganism;Modeling;mouse model;Mus;Pathogenicity;Pattern;Physiology;Process;Research;Resolution;Role;Severities;Severity of illness;Structure;success;T-Lymphocyte;Time;transplantation therapy;Ulcerative Colitis;Variant;whole genome;Work

PROJECT_TITLE: Quantification of bacterial strain count in the human gut microbiome in health and disease


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Neurosciences;Regenerative Medicine

ORG_CITY: IRVINE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Vascular restoration processes are critical for improving neurological outcomes after brain injury. Using innovative imaging technologies, our proposed research will longitudinally track the vasculature and associated cells with high spatial and temporal resolution to assess the dynamic cellular processes that drive post-injury microvascular repair. Our results will help to develop new and effective therapeutic interventions and treatment for acquired brain injuries.

PI_NAMEs: OBENAUS, ANDRE ;XU, XIANGMIN  (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Action Potentials;Acute;Animals;Arteries;Astrocytes;behavior test;beta catenin;Blood capillaries;Blood flow;blood perfusion;Blood Vessels;Brain;Brain Injuries;Cell Physiology;cell type;Cells;Central Nervous System;cerebral microvasculature;Cerebrovascular Circulation;Cerebrum;clinical translation;Cortical vasculature;Coupled;Data;Dextrans;Elements;Endothelial Cells;endothelial stem cell;Endothelium;excitatory neuron;Fluorescent Dyes;foot;Generations;Genetic;Growth;Head;Histologic;Image;Imaging technology;improved;in vivo;in vivo imaging;inhibitory neuron;Injury;injury and repair;innovation;Label;light weight;Longitudinal Studies;Magnetic Resonance Imaging;Measurement;Metabolism;Methods;Microscope;migration;miniaturize;Modeling;Molecular;Monitor;Motor Cortex;motor function recovery;mouse model;Movement;multidisciplinary;Mus;neovascularization;nervous system development;neural;neural circuit;neural stimulation;Neurological outcome;Neurons;novel;optogenetics;Outcome Assessment;Paint;Pattern;Perfusion;Pericytes;Phase;Physiological Processes;Plasma;Play;Process;Proliferating;quantitative imaging;Recovery;recruit;repaired;Reporter;Research;Resolution;response;restoration;Role;Rotarod Performance Test;serial imaging;Signal Transduction;Site;Speed;Stains;Synapses;temporal measurement;Testing;Therapeutic Intervention;therapeutically effective;Time;Tissue Preservation;Tissues;two-photon;Vascular Endothelial Growth Factors;Vascular remodeling;Vascularization;vasculogenesis;Veins;venule;Visualization

PROJECT_TITLE: Neural activity-dependent modulation of cortical microvascular restoration

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Heart failure with preserved ejection fraction (HFpEF) is increasing in prevalence worldwide. HFpEF patients are predisposed to atrial fibrillation (AF), a rhythm disturbance that exacerbates HFpEF and is associated with worse clinical outcomes. We have uncovered evidence of a novel mechanism of HFpEF-associated AF, and we propose here to define and manipulate underlying mechanisms.

PI_NAMEs: GILLETTE, THOMAS G;HILL, JOSEPH A (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Adenosine Monophosphate;Animals;Arrhythmia;Atrial Fibrillation;Atrial Function;Attenuated;Cardiac Myocytes;Cardiovascular system;Cells;Clinical;clinical translation;Communication;comorbidity;connexin 40;Coupling;cyclic-nucleotide gated ion channels;Data;Diabetes Mellitus;Disease;Doxycycline;effective therapy;EFRAC;Exercise;Fibrosis;FRAP1 gene;Functional disorder;gain of function;Generations;Genes;Genetic;Health Expenditures;Heart;Heart Atrium;Heart Diseases;Heart failure;Homeostasis;Human;Hypertension;Hypertrophy;Imaging Techniques;Impairment;In Vitro;in vivo;ivabradine;loss of function;Mediating;Medicine;Metabolic;Metabolic Diseases;Metformin;Methods;MLLT2 gene;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;mTOR inhibition;Mus;Muscle Cells;Nodal;novel;Obesity;Outcome;Pacemakers;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Pattern;pharmacologic;Physiological;Play;pre-clinical;Predisposition;preservation;Prevalence;Protein Kinase;Regulatory Pathway;Reporting;Role;segregation;Signal Transduction;Testing;Therapeutic;Therapeutic Effect;Tissues;Transgenic Organisms;ventricular hypertrophy

PROJECT_TITLE: Molecular Mechanisms of HFpEF-associated Atrial Fibrillation

STUDY_SECTION: CCHF

STUDY_SECTION_NAME: Cardiac Contractility, Hypertrophy, and Failure Study Section[CCHF]


NIH_SPENDING_CATS: Genetics

ORG_CITY: LA JOLLA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Work in my laboratory is focused on understanding how genomic DNA is maintained in eukaryotes and prokaryotes, and on exploring how genome maintenance machines have adopted new roles throughout evolution. Our particular areas of interest are in how chromosomes are organized, recombined, and segregated in eukaryotic meiosis; how viral RNAs are recognized by mammalian innate-immune proteins; and how bacteria have adapted canonical genome maintenance machinery to new defensive roles against viruses and pathogenic DNA molecules. Taken together, our research will provide fundamental knowledge about how organisms maintain and defend their genomes in the face of internal and external threats, and reveal how the molecular machinery underlying genome maintenance has evolved to meet these diverse threats.

PI_NAMEs: CORBETT, KEVIN DANIEL (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Adopted;Architecture;Area;assault;ATP phosphohydrolase;Bacteria;Cell division;Chromosome Structures;Chromosomes;Circular DNA;cohesin;Communities;Complex;condensin;Disease;DNA;DNA Binding;DNA Repair;Educational process of instructing;Eukaryota;Evolution;fascinate;Fellowship;Generations;Genes;Genetic Crossing Over;Genetic Recombination;Genome;genome integrity;Genomic DNA;Germ Cells;Grant Review;Haploidy;Immune;Innate Immune System;interest;Knowledge;Laboratories;Maintenance;Malignant Neoplasms;Meiosis;Messenger RNA;mid-career faculty;Mitosis;Molecular;Molecular Machines;Natural Immunity;Nerve Degeneration;NIH Center for Scientific Review;novel;Nucleic Acids;Organism;Pathogenicity;Plasmids;programs;Prokaryotic Cells;Proteins;recruit;Research;RNA;RNA-Binding Proteins;Role;Science;segregation;Sexual Reproduction;Signaling Protein;Structural Biologist;Structure;System;Translations;United States National Institutes of Health;viral RNA;Virus;Work

PROJECT_TITLE: Molecular mechanisms of nucleic acid recognition and maintenance in meiosis and innate immunity

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: This work uses a combination of genetic, population genetic, biochemical, and transcriptomic analysis of multiple tissues in multiple Drosophila species to investigate the evolution of genetic novelties and adaptive gene expression variation.

PI_NAMEs: BEGUN, DAVID J (contact)

PROJECT_TERMS: ATAC-seq;Biochemical;biochemical tools;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Drosophila genus;Evolution;experimental study;functional genomics;gene expression variation;Genetic;genetic evolution;Learning;Population;Population Genetics;reproductive;RNA Interference;Tissues;transcriptome;transcriptomics;Work

PROJECT_TITLE: Evolutionary and functional genomics of genetic novelties and expression adaptation in Drosophila


ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: This research project is to investigate the novel role of a kay inflammatory mediator interleukin-17A in the brain in promoting central inflammation, neurohumoral activation and cardiac dysfunction in an experimental model of systolic heart failure. These studies will lead to a better understanding of central inflammatory mechanisms underlying sympathetic excitation in heart failure and provide novel insights into the anti-cytokine strategies in the treatment of heart failure. Targeting the brain interleukin-17A to reduce sympathetic activation is a potential anti-inflammation therapeutic approach and may ultimately lead to clinical improvements of this devastating disease.

PI_NAMEs: WEI, SHUNGUANG  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Age;Animals;Astrocytes;Biochemistry;blood pressure elevation;Brain;Cardiovascular Diseases;Cardiovascular system;Cells;Cerebrospinal Fluid;Cessation of life;chemokine;Chronic;Circulation;Clinical;clinical development;Clinical Research;Clinical Treatment;Clinical Trials;cytokine;Data;Development;Diabetes Mellitus;Disease;economic impact;Electrophysiology (science);Etanercept;Experimental Models;Functional disorder;Healthcare Systems;Heart failure;heart function;Heart Rate;Hormonal;Hospitalization;human old age (65+);Hypertension;Hypothalamic structure;IL17 gene;immune activation;Immune response;immunocytochemistry;improved;Inflammation;Inflammation Mediators;Inflammatory;infliximab;inhibitor;Injections;innovation;insight;Interleukin-1 beta;Interleukin-6;Interleukins;Interruption;Intervention;Kidney;Link;Metabolic Diseases;Microglia;Modeling;Molecular Biology;mortality;Myocardial Degeneration;Myocardial dysfunction;Myocardial Infarction;Nerve;Neurons;Neurosciences;Neurosecretory Systems;novel;Obesity;older adult;Outcome;paraventricular nucleus;Pathogenesis;Patients;Peripheral;Pharmacologic Substance;Pharmacology;Plasma;Population;Production;Property;protective effect;Public Health;Rattus;receptor;Research;Research Priority;Research Project Grants;response;Role;Severities;Signal Transduction;socioeconomics;statistics;synergism;Systolic heart failure;targeted agent;Testing;Therapeutic;Therapeutic Intervention;therapy outcome;Tissues;TNF gene;United States;Work

PROJECT_TITLE: Novel Role of Interleukin-17 in Sympathetic Activation in Heart Failure


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Heart Disease;Lung;Prevention;Pulmonary Hypertension

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE The goal of this research is to develop cardiac quantitative susceptibility mapping (QSM), a new magnetic resonance imaging technique, for non-invasive measurement of blood oxygen saturation in the heart – an index that strongly predicts clinical outcomes but currently requires invasive testing. To do so, blood oxygenation on QSM will be validated in relation to invasively measured oxygenation, effort tolerance, and clinical outcomes in patients with pulmonary hypertension (a condition in which low blood oxygen is common). Results will address key technical and clinical knowledge gaps regarding blood oxygen measurement by cardiac QSM - towards the goal of early diagnosis, therapeutic optimization, and improved outcomes for patients with pulmonary hypertension.

PI_NAMEs: SPINCEMAILLE, PASCAL  (contact);WEINSAFT, JONATHAN W.

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: 3-Dimensional;Acceleration;Activities of Daily Living;Adult;Affect;Agreement;Anatomy;Blood;Breathing;Calibration;Cardiac;Cardiac Catheterization Procedures;Cardiac Output;Catheterization;cell water;Cellular Morphology;Cessation of life;Clinical;clinical practice;clinical prognosis;Clinical Research;Clinical stratification;cohort;Compensation;Complex;computerized data processing;Data;data acquisition;Decision Making;Disease;Disease Progression;Dose;Dyspnea;Early Diagnosis;end stage disease;Erythrocytes;Evaluation;Exercise Test;follow-up;Goals;Heart;heart function;hemodynamics;Hospitalization;human old age (65+);hypertension treatment;Imaging Techniques;Impairment;improved;improved outcome;indexing;insight;Ionizing radiation;Knowledge;Left;Life;Liver diseases;Lung;Magnetic Resonance Imaging;Magnetism;Maps;Measurement;Measures;Methods;Modeling;Monitor;mortality;Motion;Nervous System Disorder;novel;Organ;Outcome;Outcomes Research;Oxygen;Patient-Focused Outcomes;Patients;Perfusion;Phase;Physics;Physiologic Monitoring;Physiologic pulse;predict clinical outcome;Predisposition;pressure;Prevalence;Property;prospective;Protons;pulmonary arterial pressure;Pulmonary Hypertension;Radiation exposure;reconstruction;Reference Standards;Relaxation;Reproducibility;Research;respiratory;Risk;Scanning;Severities;Signal Transduction;stem;Symptoms;Techniques;Technology;Testing;Therapeutic;Time;Tissues;Transplantation;treatment optimization;Treatment outcome;United States;Validation;Vascular Diseases;Walking

PROJECT_TITLE: Noninvasive measurement of oxygenation using quantitative susceptibility mapping

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;HIV/AIDS;Immunotherapy;Infectious Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE While antiretroviral drugs have been a remarkable success in treating HIV and reducing secondary transmission, they face disadvantages of requiring lifelong adherence, long term side effects, increasing viral resistance, and cost. Chimeric antigen receptor (CAR) gene therapy was first tried and abandoned for HIV about 20 years ago, but is now becoming a successful treatment for cancer. Here we revisit CAR therapy for HIV, which would harness the immune system as a key component for a “functional cure” without need for drug treatment.

PI_NAMEs: KITCHEN, SCOTT G;YANG, OTTO O (contact)

PROGRAM_OFFICER_NAME: POON, BETTY

PROJECT_TERMS: acute infection;Address;Adherence;Alleles;Allogenic;Anti-Retroviral Agents;antiretroviral therapy;autoreactivity;Binding;Bispecific Antibodies;Bone Marrow Transplantation;Bypass;cancer immunotherapy;cancer therapy;Caucasians;CD3 Antigens;CD34 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell surface;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;chronic infection;Clinical;clinical application;Clinical Trials;Containment;coping;cost;Cytomegalovirus Infections;Cytoplasmic Protein;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data;design;Disadvantaged;Disease Progression;Down-Regulation;Engraftment;Epitopes;Exclusion;Face;Failure;Future;gene therapy;genetic evolution;Genome Scan;Hematopoietic;Hematopoietic stem cells;Histocompatibility Antigens Class I;HIV;HIV Envelope Protein gp120;HIV Infections;HIV therapy;HIV-1;Human;human adult stem cell;humanized mouse;Immune;Immune system;Immunodeficient Mouse;Immunologics;In Vitro;in vivo;Individual;Infection;interest;Length;Macaca;Major Histocompatibility Complex;Malignant Neoplasms;Morbidity - disease rate;mortality risk;mouse model;Mus;neutralizing antibody;novel;novel strategies;Pathway interactions;Periodicals;Persons;Pharmaceutical Preparations;Pharmacotherapy;Play;precursor cell;prevent;Proteins;prototype;Race;receptor binding;reconstitution;response;Role;Scanning;self-renewal;side effect;SIV;Source;stem;stem cell delivery;success;Surface;T-Cell Development;T-Cell Receptor;T-Cell Receptor Genes;T-Lymphocyte;Technology;Testing;Therapeutic;transmission process;Viral;viral resistance;Viremia;Virus;Virus Diseases;virus genetics;Visit

PROJECT_TITLE: Therapeutic Anti-HIV Chimeric Antigen Receptors Via Stem Cell Delivery

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Clinical Research;Hematology;Immunization;Immunotherapy;Infectious Diseases;Lymphatic Research;Lymphoma;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Vaccine Related

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE The long-term effects of CAR-T cell therapies (CARTx) on pathogen-specific humoral immunity and infection risk are poorly understood. There are no data to guide evidence-based approaches to prophylactic strategies, such as vaccination or immunoglobulin replacement, to prevent infections in this rapidly growing high-risk population. This proposal will characterize antibody levels and vaccine responses after CARTx, and how these results vary by treatment and clinical characteristics, to improve long-term outcomes after CARTx.

PI_NAMEs: HILL, JOSHUA AIDEN (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Acute;Acute Lymphocytic Leukemia;Adult;Affect;Age;Antibodies;Antigens;B cell differentiation;B cell therapy;B lymphoid malignancy;B-Lymphocytes;Blood;Blood Tests;cancer immunotherapy;cancer therapy;CAR T cell therapy;CD19 gene;Cell Lineage;Cell Maturation;Cells;Characteristics;Childhood;Childhood Leukemia;Clinical;Communicable Diseases;cost effective;cytokine release syndrome;Data;Dedications;Development;Diphtheria;Disease remission;Ensure;Epidemiology;Epitopes;evidence base;FDA approved;Frequencies;Goals;Guidelines;Haemophilus influenzae;Hepatitis A;Hepatitis B;high risk population;Humoral Immunities;immune-related adverse events;Immunity;Immunocompetence;Immunoglobulin A;Immunoglobulin G;Immunoglobulin M;Immunoglobulins;Immunologic Markers;Immunooncology;Immunotherapy;improved;improved outcome;indexing;Individual;Infection;Infection prevention;infection risk;Influenza B Virus;innovation;Institution;Intravenous Immunoglobulins;Kinetics;Knowledge;Laboratories;Long-Term Effects;Medicine;Memory B-Lymphocyte;Methods;Minority;Modeling;Multiple Myeloma;neurotoxicity;Non-Hodgkin's Lymphoma;Non-Malignant;novel;observational cohort study;Observational Study;Outcome;pathogen;pathogenic virus;Patients;Pertussis;Plasma Cells;Population;pragmatic intervention;preservation;programs;prophylactic;prospective;Recovery;Relapse;Research Personnel;Research Proposals;response;risk stratification;Sampling;Scanning;selective expression;statistics;Streptococcus pneumoniae;Subgroup;success;T-Cell Receptor Therapy;T-Lymphocyte Subsets;targeted treatment;Testing;Tetanus;Time;time use;tumor;Vaccinated;Vaccination;vaccination strategy;vaccine response;Vaccines;Viral;Virus

PROJECT_TITLE: Humoral immunity after CAR-T cell therapy for B cell malignancies: The HICAR Study


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD);Neurosciences;Orphan Drug;Precision Medicine;Radiation Oncology;Rare Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative: Almost all clinical magnetic resonance imaging (MRI) scans are inherently qualitative, which leads to subjective analysis and poor center-to-center reproducibility. This project is to develop and clinically translate a novel quantitative MR scan called MR Fingerprinting, and a quantitative image analysis software called MRF-QIA into the clinical workflow, through an academic and industry partnership. We will also clinically validate a specialized application for predicting tumor infiltration in glioblastoma patients that will eventually allow personalized treatment planning to improve patient outcomes.

PI_NAMEs: BADVE, CHAITRA ;DAVATZIKOS, CHRISTOS ;MA, DAN  (contact)

PROGRAM_OFFICER_NAME: KIM, BOKLYE

PROJECT_TERMS: 3-Dimensional;Address;Aminolevulinic Acid;Binding;Biopsy;Brain Neoplasms;Brain scan;brain tumor imaging;cancer imaging;Clinical;clinical application;clinical care;clinical imaging;clinical implementation;Clinical Protocols;Clinical Research;clinical research site;clinical translation;Clinical Trials;Collaborations;Comprehensive Cancer Center;Computer software;computerized data processing;Consumption;Country;Development;Diagnosis;digital;Drops;Ensure;Environment;Excision;experience;Fingerprint;Future;Glioblastoma;Glioma;Goals;Healthcare;Image;Image Analysis;imaging biomarker;Imaging Device;imaging platform;Imaging Techniques;improved;improved outcome;industry partner;Infiltration;Institution;interest;Licensing;Machine Learning;Magnetic Resonance Imaging;Malignant neoplasm of brain;Malignant Neoplasms;Maps;Marketing;Measurement;Measures;MRI Scans;Multi-Institutional Clinical Trial;Neurosurgeon;neurosurgery;Newly Diagnosed;next generation;novel;Operative Surgical Procedures;outcome prediction;Pathologic;Pathology;Patient Care;Patient-Focused Outcomes;Patients;Performance;performance site;personalized medicine;Physicians;Physiological;predictive modeling;predictive tools;Property;prospective;quantitative imaging;Radiation Dose Unit;Radiation Oncologist;Radiation therapy;Radiogenomics;radiologist;Radiology Specialty;radiomics;reconstruction;recruit;Recurrence;Relaxation;Reproducibility;Research;Sampling;Scanning;Site;Standardization;synergism;System;targeted treatment;Techniques;Testing;Therapy trial;Time;Tissue Sample;Tissues;tool;Translating;Travel;treatment planning;trial comparing;trial planning;tumor;Validation;Variant;Vendor;volunteer

PROJECT_TITLE: MR Fingerprinting based Quantitative Imaging and Analysis Platform (MRF-QIA) for brain tumors.


PHR: PROJECT NARRATIVE When retroviruses infect a host, their reverse transcriptase can sometimes duplicate genes by ‘retrocopying’ host mRNAs back into the genome. Some of these new genes likely contribute to the function of the innate immune system, modifying an individual’s susceptibility and resistance to infectious viruses. Our proposed project will find young and polymorphic retrocopied innate immune genes, assay their ability to promote or restrict viral infection, and begin to define the consequences of overlooked retrocopies on viral infections and human immunity.

PI_NAMEs: MCLAUGHLIN, RICHARD NOEL (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: Alleles;Animals;Anti-viral Response;APOCEC3G gene;Back;Binding;Biochemistry;Biological Assay;Birth;Cebidae;cell type;Cells;cofactor;Communicable Diseases;Computational Biology;Data;Dependence;dimer;Dimerization;Disease Outcome;Disease susceptibility;Disparate;Dominant-Negative Mutation;EEF1A1 gene;Elongation Factor;Exons;Expression Profiling;Family;Frequencies;Gene Duplication;Gene Family;gene interaction;Genes;Genetic Determinism;Genetic Polymorphism;Genetic Transcription;Genome;genome analysis;Germ Lines;Haploidy;Haplotypes;Heritability;high throughput screening;Human;Human Genome;human reference genome;Immune;Immune response;immune system function;Immunity;In Vitro;Individual;individual variation;inhibitor;innate immune function;Innate Immune System;insertion/deletion mutation;Interferons;Invaded;Knock-out;Link;Location;Maps;Measures;Mediating;Messenger RNA;Mutation;Natural Immunity;Outcome;pathogen;Peptide Fragments;Peptides;Phase;Pongidae;Population;Predisposition;Primates;Process;promoter;prospective;Proteins;Pseudogenes;Publishing;Recording of previous events;Research;Resistance;Retroviridae;Retroviridae Infections;Reverse Transcription;RNA Viruses;RNA-Directed DNA Polymerase;Role;Shapes;Signal Transduction;Source;Technology;Testing;Tissues;transcription factor;Translating;Translations;Variant;Viral;Viral Genes;Viral Physiology;virology;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Reverse transcriptase-mediated expansion of the host innate immune system

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Gene Therapy;Genetics;Immunotherapy;Pancreatic Cancer;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Most pancreatic cancers are found after metastasis or spread to surrounding areas, and require new approaches for systemic treatment. In order to achieve such therapeutics, we will generate a new series of OAds based on a variety of Ad species with the fiber-knob region specifically bind to surface molecule of pancreatic cancer cells. This project will enable systemic therapy of PDAC with oncolytic virus by exploiting the advantages of the adenoviral vector system and our unique advantages in adenovirus targeting strategies.

PI_NAMEs: YAMAMOTO, MASATO  (contact)

PROGRAM_OFFICER_NAME: CHRISTEN, JAYNE

PROJECT_TERMS: Adenovirus Infections;Adenovirus Vector;Adenoviruses;Adoptive Transfer;advanced disease;Adverse effects;Antineoplastic Agents;antitumor effect;Area;Binding;cancer cell;Characteristics;chemotherapy;Clinic Visits;Clinical;clinically relevant;conditionally replicative adenovirus;design;Development;Diagnosis;Erythrocytes;Fiber;Generations;Goals;Hamsters;Hemagglutination;high throughput screening;Human;Immunize;immunogenic cell death;Immunosuppression;improved;In Vitro;in vivo;in vivo evaluation;in vivo Model;Infection;Injectable;Injections;Libraries;Liver;Lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;mesothelin;Modeling;Mus;Neoplasm Metastasis;neutralizing antibody;novel;novel strategies;oncolysis;oncolytic adenovirus;Oncolytic viruses;Operative Surgical Procedures;Organ;Outcome;Pancreas;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Patients;Process;Prognosis;promoter;Proteins;PTGS2 gene;Refractory;Reporting;Series;Serology;Seroprevalences;Serum;Specificity;Subgroup;Surface;Survival Rate;System;Systemic Therapy;Testing;Therapeutic;Therapeutic Effect;Thrombosis;Time;Toxic effect;Tropism;tumor;Tumor Antigens;Tumor stage;Vertebral column;Viral;Virus;Xenograft Model

PROJECT_TITLE: Advanced Oncolytic Adenovirus Enabling Systemic Therapy of PDAC

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


NIH_SPENDING_CATS: Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Heart Disease;Physical Activity;Prevention

ORG_CITY: WORCESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Cardiovascular disease, the number one leading cause of death in the United States, is highly prevalent in cancer survivors. Physical activity can reduce risk, and referrals to programs addressing survivors’ choices are highly recommended from providers in cancer survivorship, though rarely implemented. We propose to develop ActivityChoice, a clinic-based implementation program, using patient narrative decision aids to support choices to a group in-person, group virtual, or self-monitored digital health physical activity program.

PI_NAMEs: FARO, JAMIE  (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Address;Adoption;Aftercare;American Heart Association;cancer diagnosis;Cancer Survivor;Cancer Survivorship;Cardiovascular Diseases;cardiovascular disorder risk;Caring;Cause of Death;Clinic;Clinical;clinical implementation;Collaborations;Communities;community advisory board;Computerized Medical Record;COVID-19;Data;Decision Aid;design;Development;digital health;digital monitoring;Effectiveness;Electronics;Enrollment;evidence base;Evidence based program;experience;Feedback;fitbit;flyer;follow-up;Future;General Population;Grant;Health;health related quality of life;Hearing;implementation outcomes;Institute of Medicine (U.S.);Institution;Intervention;Interview;Leadership;Letters;Light;Malignant Neoplasms;meetings;Mentored Clinical Scientist Development Program;Mentors;Monitor;mortality;multi-site trial;novel;Outcome;Paper;Participant;Pathway interactions;patient engagement;patient oriented;Patient Outcomes Assessments;patient-clinician communication;Patient-Focused Outcomes;Patients;Persons;Physical activity;physical conditioning;pilot test;Practical Robust Implementation and Sustainability Model;Pragmatic clinical trial;pragmatic trial;prevent;Process;programs;Protocols documentation;Provider;randomized trial;Recommendation;Regulation;Reporting;Research Personnel;Resources;Risk;Risk Factors;Risk Reduction;Role playing therapy;Secure;sedentary;Self Determination;shared decision making;Site;skills;stakeholder perspectives;standard of care;support tools;Surveys;Survivors;survivorship;System;tailored messaging;Testing;theories;Time;tool;Training;Uncertainty;United States;virtual group;Visit;Walking;Work

PROJECT_TITLE: ActivityChoice: A clinic-delivered implementation program to increase physical activity and decrease cardiovascular disease risk amongst cancer survivors

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Prevention;Suicide;Suicide Prevention

ORG_CITY: NOTRE DAME

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: PROJECT NARRATIVE The proposed research will address a significant health concern, the rise of suicide rates, by developing an adaptive time assessment system to provide a more nuanced insight into the time course of suicidal thoughts and prominent risk factors. NIH’s mission, and NIMH’s strategic priorities, will be served by the proposed study through enhanced identification of when individuals are at risk for suicide, allowing for early implementation of suicide prevention and intervention efforts and ultimately reducing suffering and mortality.

PI_NAMEs: AMMERMAN, BROOKE A;JACOBUCCI, ROSS  (contact)

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Acute;adaptive intervention;Address;algorithm training;Algorithms;arm;assessment application;Benchmarking;Calibration;Data;Data Analyses;Data Collection;data streams;Detection;Development;Ecological momentary assessment;effective intervention;experience;Feeling suicidal;Friends;Health;Heterogeneity;high risk;Hour;implementation intervention;improved;Individual;innovation;insight;Intervention;Knowledge;Literature;Machine Learning;Mental Health;Methods;Mission;Modeling;mortality;National Institute of Mental Health;novel;Outcome;Participant;Performance;personalized predictions;Persons;Phase;prospective;Public Health;reducing suicide;Reporting;Research;Resolution;response;Risk;Risk Factors;Sampling;Schedule;Scheme;societal costs;Statistical Models;suicidal risk;Suicide;Suicide prevention;suicide rate;System;Time;Training;United States National Institutes of Health;Update;Validation;Variant;web app;Work

PROJECT_TITLE: Improving momentary suicide risk identification through adaptive time sampling

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Biotechnology;Lung;Pulmonary Fibrosis

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Pulmonary fibrosis is a devastating disease associated with debilitating shortness of breath and a rapid progression to death. Because current medication options are limited, it is critical that new treatments are identified. Plasminogen activator inhibitor-1 (PAI-1) represents an exciting therapeutic target because it potently drives lung fibrosis in multiple different models, but the mechanisms by which PAI-1 causes fibrosis requires further elucidation to optimally devise strategies of inhibition.

PI_NAMEs: LAWRENCE, DANIEL A;SISSON, THOMAS H (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Afibrinogenemia;aging related disease;alveolar epithelium;Alzheimer's Disease;Animal Model;Atherosclerosis;Attenuated;Binding;Biology;Biotin;Bleomycin;Cell Line;Cell Surface Receptors;Cells;Cessation of life;Chimeric Proteins;Cicatrix;Confocal Microscopy;Cytoplasm;Data;design;Diagnosis;Disease;Disease Pathway;Disease Progression;efficacious intervention;efficacious treatment;Endocytosis;Epithelial Cells;Essential Amino Acids;experience;experimental study;Fibrinolysis;Fibroblasts;fibrogenesis;Fibrosis;fibrotic lung;Foundations;Gene Deletion;Heart;Human;idiopathic pulmonary fibrosis;In Vitro;in vivo;Incidence;inhibitor;Kidney;Knock-in Mouse;Label;Lesion;Ligands;Ligase;Liver;Lung;lung development;Lung Diseases;lung injury;Mediating;Mediator;Modeling;Molecular Biology Techniques;Morbidity - disease rate;mortality;mosaic;mouse model;Mus;mutant;Mutation;mutation screening;new therapeutic target;novel;Organ;overexpression;Pathway interactions;Patients;Phage Display;Pharmaceutical Preparations;Phenotype;Plasminogen Activator;Plasminogen Activator Inhibitor 1;Plasminogen Activator Interaction;prevent;Profibrotic signal;protein reconstitution;Protein Sortings;Proteins;Proteomics;prototype;Pulmonary Fibrosis;receptor;Regulation;Role;Severities;Shortness of Breath;Skin;small molecule;sortilin;Stimulus;Surface Plasmon Resonance;Testing;Therapeutic;therapeutic target;Tissues;Transforming Growth Factor beta;Transgenic Mice;uptake;Urokinase;validation studies;Vitronectin;wound healing

PROJECT_TITLE: A Novel PAI-1 Function Drives Lung Fibrosis

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative Obesity which has become extremely prevalent in the United States is a major trigger of high blood pressure which is a leading cause of heart attacks, heart failure and stroke. The focus of this project is to explore the processes employed by the brain to regulate blood pressure and understand how dysregulation in these processes cause high blood pressure in obesity. Thus, this proposal should fundamentally advance our understanding of the mechanisms that underlies the cardiovascular diseases caused by obesity.

PI_NAMEs: RAHMOUNI, KAMAL  (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Affect;Animals;Automobile Driving;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure regulation;Brain;Cardiovascular Diseases;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;clinically relevant;Conscious;Data;designer receptors exclusively activated by designer drugs;diet-induced obesity;Electrophysiology (science);Endocrine;Epidemic;Etiology;Fiber;fibroblast growth factor 21;Genetic;Genetically Engineered Mouse;Goals;Heart failure;Homeostasis;Hormones;Hypertension;Hypothalamic structure;improved;innovation;insight;Kidney;Knowledge;mad itch virus;Mediating;Methods;Modernization;Molecular;Monitor;Morbidity - disease rate;mortality;multidisciplinary;Mus;Myocardial Infarction;Nerve;neural;neuronal excitability;Neurons;neurotechnology;novel;Obese Mice;Obesity;optogenetics;Organ;Persons;Phenotype;Photometry;Physiological Processes;Physiology;Play;Population;pressure;Process;receptor;Regulation;Research;response;Role;SF1;side effect;Signal Transduction;Slice;Stroke;Testing;Therapeutic;therapeutically effective;Thinness;United States;Work

PROJECT_TITLE: Role of FGF21 Action in Hypothalamic Neurons in Obesity-Associated Hypertension

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Women's Health Research

ORG_CITY: CHAMPAIGN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: PROJECT NARRATIVE The goal of this project period is to make infrared (IR) spectroscopic imaging practical for routine pathology and evaluate whether it’s application can improve patient outcomes. In the last project period, we developed “high definition” IR imaging that provided unprecedented quality and accuracy in pathology but the instrument was too slow to be practical and did not take advantage of emerging spatial-spectral machine learning methods like deep learning. Here we propose a new instrument design and a robust, accurate and precise analytical approach to speed up sample-to-information time, a critical step in becoming practical for pathology laboratory and intra- operative use.

PI_NAMEs: BHARGAVA, ROHIT  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: Address;Algorithms;analytical method;anti-cancer research;Area;Biopsy;Breast;breast imaging;breast pathology;cancer care;Cancer Center;cell type;Cells;Characteristics;Chemicals;Classification;Clinical;clinical diagnosis;Clinical Pathology;clinical practice;Clinical Research;Cognition;college;Complex;Computer Assisted;Computer software;Custom;Data;Data Analyses;data modeling;data quality;deep learning;design;Detection;Development;Diagnosis;digital;Disease;Dyes;Electronics;Engineering;Estrogen receptor positive;Evaluation;Excision;Foundations;Frequencies;Genomics;Goals;Grant;Healthcare;Histologic;Histopathology;Hour;Human;Image;imaging approach;Imaging Device;imaging system;Imaging technology;improved;innovation;instrument;Knowledge;Label;Laboratories;Lasers;Legal patent;Lesion;Light Microscope;Machine Learning;machine learning method;Malignant Breast Neoplasm;Mammary Gland Parenchyma;Mammary Neoplasms;Manufacturer;Measurement;Measures;Medicine;meter;Methods;Microscope;Microscopy;Modeling;Molecular;molecular pathology;Molecular Profiling;Morphology;Noise;novel;Operative Surgical Procedures;optical imaging;Optics;Outcome;Pain;Pathologist;Pathology;Pathology processes;Patient-Focused Outcomes;Patients;Peer Review;Performance;Physical environment;pre-clinical;predictive modeling;Problem Sets;Protocols documentation;Public Health;Publications;Publishing Peer Reviews;Qualifying;quantum;Recording of previous events;Recurrence;Reporting;Research;Research Personnel;Resolution;Resources;Risk Assessment;Sampling;Scanning;Scheme;Signal Transduction;Specimen;spectroscopic imaging;Speed;Stains;Sterile coverings;Surgical margins;technological innovation;Technology;technology validation;temporal measurement;Time;Tissue Microarray;Tissue Stains;Tissues;tool;Training;Translations;tumor;tumor microenvironment;Validation;Vision;Work

PROJECT_TITLE: Discrete Frequency Infrared Spectroscopic Imaging for Breast Histopathology

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: It is well-known that African Americans (AAs) face a higher risk and burden of colorectal cancer (CRC), but which genetic pathways or environmental/social determinants add to the risk of colorectal cancer are not well-known. Our overall working hypothesis is that the archaea in the human gut lumen are different in AAs compared to Non-Hispanic Whites (NHWs) and this difference (either in the numbers of archaea, types and/or function) contributes to the racial disparities observed in CRC.

PI_NAMEs: MUTLU, ECE A. (contact)

PROGRAM_OFFICER_NAME: DUGLAS TABOR, YVONNE

PROJECT_TERMS: Adenomatous Polyps;African American population;Age;Alcohol consumption;Archaea;Bacteria;Bile Acids;Biological Assay;Body mass index;cancer health disparity;cell envelope;cohort;Colon;colon bacteria;Colon Carcinoma;Colorectal Cancer;colorectal cancer risk;comparison control;Constipation;Control Groups;Data;Data Set;Diet;Environment;Environmental Risk Factor;Ethnic Population;Face;Feces;Formates;Funding;Gases;Genetic;Genomics;Growth;gut bacteria;gut microbiome;high risk;Hong Kong;Human;Hydrogen;Individual;Inflammatory Bowel Diseases;Ingestion;Intestines;Irritable Bowel Syndrome;Knowledge;Lactulose;media use;Metabolism;Metadata;metagenome;metagenomic sequencing;Metagenomics;Methane;Methanobacteria;Methanobrevibacter;microbial;microbiome;Not Hispanic or Latino;Nucleic Acids;Pathway interactions;Patients;Polyps;Predisposition;prevent;Production;Protocols documentation;racial disparity;racial population;Rest;sample collection;Sampling;sex;Shotguns;Smoking;social;social determinants;Spain;Specimen;stool sample;Structure;United States National Institutes of Health;Validation

PROJECT_TITLE: Archaea in African Americans with polyps

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Y(55)R]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Nanotechnology;Orphan Drug;Prevention;Rare Diseases

ORG_CITY: Columbus

ORG_DEPT: DENTISTRY

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative: Oropharyngeal cancer, which arises from precancerous oral lesions, will affect over 53,200 persons in the US during 2020. The best way to manage this deadly disease is to prevent precancerous lesions from becoming oral cancer. These studies will investigate a thin film that releases cancer-preventing particles throughout the mouth.

PI_NAMEs: MALLERY, SUSAN R (contact)

PROGRAM_OFFICER_NAME: WOJTOWICZ, MALGORZATA E

PROJECT_TERMS: 17p;ABL1 gene;absorption;Address;Adhesives;Adult;Affect;Affinity;Alcohol consumption;antagonist;autocrine;Basal Cell;Bathing;Binding;Biological Assay;Biological Availability;carcinogenesis;carcinogenicity;Carcinogens;Cells;Cessation of life;Charge;Chemoprevention;Chemopreventive Agent;Clinical;Clinical Research;Clinical Trials;Combined Modality Therapy;cytokine;Cytoskeleton;Data;Development;Disease;Distant;DNA Repair;Dose;Drug Delivery Systems;Drug Kinetics;drug release kinetics;Eating;Electron Microscopy;Enzymes;Epithelium;Esthetics;Evaluation;Excision;experience;exposure route;Exposure to;Face;Fanconi's Anemia;Fenretinide;Film;Formulation;Goals;Growth;healthy volunteer;High Pressure Liquid Chromatography;Histologic;Human;Hydrogels;IL6 gene;Image Analysis;immunoreactivity;In Vitro;in vivo;in vivo Model;Inflammatory;inhibitor;Injections;Interleukin 6 Receptor;Intraepithelial Neoplasia;Invaded;keratinocyte;Lead;Lesion;light scattering;local drug delivery;Loss of Heterozygosity;Malignant - descriptor;Malignant Epithelial Cell;malignant mouth neoplasm;Malignant Neoplasms;malignant oropharynx neoplasm;Metabolism;Methodology;migration;Modality;Modeling;monolayer;Morbidity - disease rate;mouse model;mouth squamous cell carcinoma;Mucous body substance;Mucous Membrane;nanocarrier;nanoparticle;Nature;Operative Surgical Procedures;Oral;Oral cavity;oral cavity epithelium;oral lesion;Oral mucous membrane structure;Oryctolagus cuniculus;Outcome;oxidation;paracrine;particle;Pathway interactions;Patients;Penetration;Peptides;Persons;Pharmaceutical Preparations;Phase;Phase 0 Trial;Phosphotransferases;Plasma;premalignant;prevent;Primary Neoplasm;Property;PTK2 gene;Resistance;Risk;Risk Factors;Role;Saliva;Shapes;side effect;Signal Transduction;Site;social;Squamous cell carcinoma;SRC gene;STAT3 gene;Stromal Cells;Structure;Surface;systemic toxicity;Therapeutic;Thinness;Time;Tissues;tobacco products;Tobacco use;tocilizumab;Toxic effect;Toxicology;tumor;Urine;viscoelasticity;Vitamin A;volunteer;Xenobiotics;Xenograft procedure;zeta potential

PROJECT_TITLE: Formulation, Evaluation, and Phase 0 Trial of Nanoparticle Releasing Oral Thin Film for OSCC Chemoprevention

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


NIH_SPENDING_CATS: Autoimmune Disease;Genetics

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Autoimmune diseases represent a significant health burden that arises when there is a breakdown in immune tolerance to self, and multiple mechanisms are in place to ensure such immune self-tolerance. The thymus is a critical site for immune tolerance, where thymic epithelial cells have a unique ability to express and present all self-antigens to the developing T cells. This project aims to increase our understanding of the regulation of this process as several genes involved in this process are found to be mutated in patients with autoimmunity.

PI_NAMEs: WATERFIELD, MICHAEL R (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Adult;Affect;Antigens;Apoptosis;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmunity;autoreactive T cell;B-Lymphocytes;Biological;Biological Models;Cell Line;Cell Lineage;Cell Ontogeny;Cell Physiology;Cells;central tolerance;Chromatin;Clinical;Complex;Data;Defect;Developed Countries;Development;Education;Ensure;Epithelial Cell Proliferation;Epithelium;Family;fetal;Flow Cytometry;Gene Expression;gene expression database;Gene Expression Profiling;Genes;Genetic;Genetic Transcription;Goals;Growth;Health;Hematopoiesis;Hematopoietic;Heterogeneity;Homeostasis;Human;Immune;immune self tolerance;Immune system;Immune Tolerance;improved;In Vitro;in vivo;inducible Cre;insight;Knowledge;Link;Lymphocyte;Malignant Neoplasms;Mediating;Modeling;Molecular;mouse model;multiple omics;Mus;mutant mouse model;Mutate;Mutation;novel;Patients;Phenotype;Play;Population;Positioning Attribute;prevent;Process;progenitor;programs;Regulation;Reporter;Reporting;Role;Sampling;Self Tolerance;single cell ATAC-seq;single-cell RNA sequencing;Site;Structure of thymic medulla;T-Lymphocyte;Technology;Testing;Thymic epithelial cell;Thymus Gland;Tissues;tool;transcription factor;Transcriptional Regulation;Variant;Work;Zinc Fingers

PROJECT_TITLE: Regulation of medullary thymic epithelial cells and thymic central tolerance by Ikaros

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Diabetes;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Project Narrative Diabetes aggravates atherosclerosis development and progression, which causes many cardiovascular diseases, including heart attacks, strokes, and peripheral vascular disease. The goal of this proposal is to explore the role and mechanisms by which coiled-coil domain containing 92 (CCDC92) induces vascular smooth muscle cell dysfunction and atherosclerosis under diabetic conditions. Our study will shed light on the vascular effects of CCDC92 and the human variants, which would serve as the foundation for the future therapeutic strategy for diabetes-associated CVD.

PI_NAMEs: FAN, YANBO  (contact)

PROGRAM_OFFICER_NAME: PLAYFORD, MARTIN P

PROJECT_TERMS: Accounting;American;Animal Model;Aorta;Apoptosis;Arterial Fatty Streak;atherogenesis;Atherosclerosis;Biogenesis;Biological Process;Blood Vessels;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Cell Physiology;Cell Separation;Cessation of life;Clinical;clinical practice;clinically relevant;Code;Coiled-Coil Domain;Coronary heart disease;Crossbreeding;Data;Development;Diabetes Mellitus;diabetic;diabetic patient;Disease;Epidemic;euglycemia;Event;experimental study;Foundations;Functional disorder;Future;Genetic;Genetic study;Genetic Transcription;genetically modified cells;Glucose;Goals;High Fat Diet;Histologic;Human;Human Biology;human disease;Impairment;In Vitro;in vivo;Inflammation;Insulin Resistance;Knock-in Mouse;Knock-out;Knockout Mice;Lysosomes;Measures;Mediating;Methods;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Myocardial Infarction;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Nuclear Translocation;overexpression;Pathogenesis;Pathologic;Pathway interactions;Patients;Peripheral Vascular Diseases;Phenotype;Prevalence;Prevention;protective effect;Reporting;Research;Role;Smooth Muscle Myocytes;statistics;Stimulus;Stroke;Testing;Therapeutic;transcription factor;Transgenic Mice;Transgenic Organisms;Variant;Vascular Smooth Muscle

PROJECT_TITLE: CCDC92 and cardiovascular disease

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: BLACKSBURG

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE Our body’s stress response system helps us adapt to everyday stressors, but maladaptive stress responses can cause stress-associated disorders such as anxiety and depression. To develop new therapies for stress- related disorders, it is critical to uncover the fundamental molecular and developmental mechanisms for stress response regulation. This proposal will elucidate how neuronal cell death is triggered within the stress response pathway and determine whether the extent of cell death determines the level of stress response pathway activation.

PI_NAMEs: PAN, YUCHIN ALBERT (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: acute stress;Address;Affect;analog;Animals;Anxiety;Apoptosis;biological adaptation to stress;Brain;Cell Count;Cell Death;cell type;Cells;Corticotropin;Corticotropin-Releasing Hormone;CRISPR/Cas technology;Development;Disease;Down Syndrome Cell Adhesion Molecule;early life stress;Excitatory Synapse;experimental study;Functional disorder;Future;gain of function;Genetic;Glucocorticoid Receptor;Glucocorticoids;Growth;Health;Hormones;Hydrocortisone;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;Image;Impairment;interest;Knowledge;Measures;Mediating;Mental Depression;Mental disorders;Modeling;Molecular;Monitor;mutant;Mutate;neural;neural circuit;neuron loss;neuronal excitability;neuronal survival;Neurons;Neurosecretory Systems;novel therapeutics;NRCAM gene;Optics;Pathway interactions;Pattern;Pituitary Gland;Play;Population;postsynaptic neurons;presynaptic neurons;Regulation;Retina;Risk;Rodent;Role;Stress;stress related disorder;stressor;Synapses;synaptogenesis;System;Testing;tool;Zebrafish

PROJECT_TITLE: Mechanisms and significance of programmed cell death in hypothalamic CRH neurons

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Lung injury caused by respiratory viral infections lead to significant mortality and morbidity in the United States. In this proposal, we will investigate how specialized cells in the lungs, termed pericytes, mediate inflammation and vascular dysfunction. Improved understanding of the role of pericytes in lung response to influenza infection may lead to future targeted therapeutic interventions to reduce lung injury in response to influenza and other viral pneumonias.

PI_NAMEs: HUNG, CHI F (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Acute;Acute Lung Injury;Acute Respiratory Distress Syndrome;Affect;Alveolar;alveolar epithelium;angiogenesis;Angiogenic Factor;Angiopoietins;ANGPTL4 gene;Attenuated;Biology;Blood Platelets;Blood Vessels;CC chemokine receptor 2;CCL2 gene;CCL7 gene;Cell Adhesion Molecules;Cell Nucleus;cell type;Cells;chemokine;chemokine receptor;clinically relevant;combinatorial;cytokine;Data;Detection;Development;Emigrations;Endothelial Cells;Endothelium;Epithelial Cells;Epithelium;Functional disorder;Future;Genes;Genetic Transcription;Goals;immunoregulation;improved;indexing;Individual;Inflammation;Inflammatory;Inflammatory Response;Influenza;influenza infection;influenza pneumonia;Injury;insight;Intercellular adhesion molecule 1;interstitial;interstitial cell;intravital microscopy;Kidney;Lead;Leukocytes;Ligands;Lung;lung development;Lung infections;lung injury;lung repair;Maintenance;Mediating;migration;Modeling;Molecular;Molecular Profiling;monocyte;Morbidity - disease rate;mortality;mouse model;Muscle;neutrophil;novel;novel therapeutic intervention;Organ;Pathogenesis;Pathogenicity;Pattern;Pericytes;Permeability;Phenotype;Play;Population;Positioning Attribute;programs;Publishing;recruit;Regulation;Research;Resolution;response;response to injury;Risk;Risk Factors;Role;segregation;Sentinel;Signal Pathway;Signal Transduction;Skin;Stromal Cells;Surface;targeted treatment;Testing;Therapeutic Intervention;tissue injury;tissue repair;Tissues;trafficking;transcriptome sequencing;transcriptomics;United States;Up-Regulation;Vascular Diseases;vasculogenesis;Viral Pneumonia;Viral Respiratory Tract Infection;Work

PROJECT_TITLE: Functional diversity of lung pericytes in lung injury


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Lung

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Exposure to microplastic fibers that are embedded with azobenzene disperse dyes (ADD) may be associated with lung injury that includes allergic airway disease. This application investigates the potential toxicity of aerosolized textile-relevant ADD dyed microplastic fibers to the lung and associated novel mechanisms that include ADD protein adduct formation. Such first time information crucial to understanding long-term health effects of microplastic fibers.

PI_NAMEs: MEHRAD, BORNA  (contact)

PROGRAM_OFFICER_NAME: RAVICHANDRAN, LINGAMANAIDU V

PROJECT_TERMS: Acute;Address;adduct;aerobic respiration control protein;aerosolized;Aerosols;Air;air sampling;airway epithelium;Allergic;allergic airway disease;Allergic Reaction;allergic response;Asbestos;Asthma;asthma model;azobenzene;Binding;bronchial epithelium;carcinogenicity;Cell Culture Techniques;Cell Differentiation process;Cells;Chemicals;Chronic;Coculture Techniques;Color;Complex;Custom;cytokine;cytotoxicity;Data;Dendritic Cells;Dermal;Development;Disease;Dissociation;Distant;Dyes;Ecosystem;Environment;Environmental Pollutants;Epidemiology;epidemiology study;Epithelial Cells;Epithelium;Event;experimental study;exposure route;Exposure to;Fiber;Gene Expression Profiling;Genes;hazard;Health;House Dust;Household;Human;Immune;Immune response;immunogenic;Impairment;improved;In Vitro;in vivo;Industrialization;Inflammation;Inhalation;Inhalation Exposure;injured airway;Interstitial Lung Diseases;Investigation;Knowledge;Lead;Liquid substance;Lung;lung injury;Macrophage;manufacturing process;Mass Spectrum Analysis;Measures;Mineral Fibers;Molecular;mouse model;Mus;novel;Oral;Outcome;Pathway interactions;Phenotype;Plastics;Pollution;Polyesters;Polyethylene Terephthalates;Process;Production;Property;Proteins;Proteomics;Pulmonary Fibrosis;Research;respiratory;response;Risk Assessment;Skin;Source;Structure of parenchyma of lung;System;Testing;Textiles;TGFB1 gene;Time;Toxic effect;Toxicology;Water;Work

PROJECT_TITLE: Assessing the Pulmonary Toxicity of Microplastic Fibers Complexed with Azo Dyes

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative/Public Health Statement Normothermic ex situ, or ex vivo, organ perfusion (EVOP) is a clinically accepted method of preserving, evaluating, and rehabilitating whole organs for transplantation. EVOP has also been utilized by scientists for translational research and emerged as an important platform to study organs with fully intact cell-cell interactions, endothelial and epithelial interfaces, and with the entire spectrum of cellular compartments seen in vivo; therefore, EVOP provides a unique platform to preserve organs for transplantation, as well as to study human physiology and pathology through preclinical translational studies, but is severely limited due to the short time frame of organ health stability currently provided by the technology. The overall objective of this proposal is to obviate that limitation of time for EVOP by adapting existing ex vivo lung perfusion strategies to allow for perpetual organ preservation and rehabilitation, or POPR.

PI_NAMEs: HARTWIG, MATTHEW GALEN (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: ATAC-seq;Biochemical;Biocompatible Materials;Biological;Biology;Biomedical Engineering;Blood Vessels;Cell Communication;cell regeneration;Cells;Cellular biology;Clinical;clinical application;Clinical Research;Consent;cost;Country;Data;Development;Devices;Discipline;Disease;Endothelial Cells;Endothelium;Ensure;Environment;Epigenetic Process;Epithelium;Evaluation;Excision;experience;experimental study;Family suidae;Filtration;Health;Heart;Heart Diseases;Heart Research;Hematological Disease;Hour;Human;immunoregulation;improved;in vivo;Individual;inflammatory marker;International;Intervention;Investigation;Kidney;Laboratories;liver preservation;Lung;lung development;Lung Diseases;Lung Transplantation;Metabolic;Methods;Modeling;new technology;Organ;Organ Donor;Organ Preservation;Organ Transplantation;Organ Viability;Outcome;Parenteral Nutrition;Pathology;Perfusion;Physiological;Physiology;porcine model;Positioning Attribute;pre-clinical;preclinical trial;preservation;Preservation Technique;Process;programs;Protocols documentation;Public Health;Publishing;pulmonary artery endothelial cell;Pulmonary Edema;Rehabilitation therapy;Reproducibility;Research;Research Personnel;research study;respiratory;sample collection;single-cell RNA sequencing;Sleep Disorders;Small Intestines;small molecule therapeutics;Solid;Specialist;Specialized Center;Specimen;Structure of parenchyma of lung;success;Techniques;Technology;Testing;Time;transcriptomics;translational model;Translational Research;translational scientist;translational study;Transplantation;Universities;Vascular Endothelium;Vascular resistance;Waste Products;Work

PROJECT_TITLE: Perpetual Organ Preservation and Rehabilitation (POPR)

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease;Organ Transplantation;Transplantation

ORG_NAME: HENNEPIN HEALTHCARE RESEARCH INSTITUTE

PHR: Project Narrative Patients waiting for a kidney transplant often face poor outcomes and increased burden of care on dialysis. During this time, transplant centers and patients may turn down organ offers that could provide a significant benefit because patients and providers lack effective interventions to help patients make informed offer decisions. A shared decision making approach can help patients plan for a future offer so they are prepared and informed when they receive an offer.

PI_NAMEs: SCHAFFHAUSEN, CORY R (contact)

PROGRAM_OFFICER_NAME: ABBOTT, KEVIN C

PROJECT_TERMS: Address;Adoption;Anxiety;Behavior;behavior change;care burden;Caring;Clinical Trials;Communicable Diseases;Complement;Conflict (Psychology);cost;cost comparison;Data;Decision Making;demographics;design;Development;Dialysis patients;Dialysis procedure;Disease;Distress;Education;Educational Intervention;effective intervention;Emotional;End stage renal failure;Enrollment;Evaluation;experience;Exposure to;Face;Family;Feedback;Fright;Future;future implementation;Goals;Health;human centered design;implementation evaluation;improved;Intervention;intervention refinement;Interview;Kidney;Kidney Transplantation;Knowledge;Medical;Methodology;Methods;Mission;Morbidity - disease rate;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Organ;Organ Donor;Organ Transplantation;Outcome;Participant;Patient Education;patient engagement;patient oriented;Patients;Persons;post intervention;preference;Preparation;primary outcome;Process;Provider;Quality of life;Questionnaires;Randomized;randomized trial;Reporting;Research;response;Risk;Risk Factors;Sampling;secondary analysis;shared decision making;Site;Sleep;Solid;success;Surgeon;System;theories;Theory of Change;Time;tool;transplant centers;Transplant Recipients;Transplantation;treatment as usual;user centered design;virtual;Waiting Lists;willingness

PROJECT_TITLE: Shared decision making for kidney transplant candidates to plan for an organ offer decision

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: PROJECT NARRATIVE Medication non-adherence is hypothesized to be a primary cause of treatment failure, mortality, and the age- related disparities in survival improvement faced by adolescents and young adults with cancer. The proposed research responds directly to the National Cancer Institute’s calls for efforts to improve adherence by pilot testing a tailored adherence-promotion intervention for adolescents and young adults with cancer. The novel intervention resulting from the proposed research will have the potential to transform current approaches to adherence-promotion and improve the health and quality-of-life among thousands of adolescents and young adults with cancer who may struggle with non-adherence.

PI_NAMEs: MCGRADY, MEGHAN EILEEN (contact)

PROGRAM_OFFICER_NAME: FERRER, REBECCA

PROJECT_TERMS: Address;Adherence;Adolescent and Young Adult;Adolescent and young adult cancer patients;Age;Age disparity;age group;Algorithms;arm;behavior change;cancer care;cancer therapy;Caring;Cause of Death;Cessation of life;Child;Clinical;Country;Data;design;Disease;Dose;Economics;Enrollment;Failure;feasibility testing;feasibility trial;Feedback;forgetting;Future;Grant;Health;Health behavior;Health Technology;improved;Income;innovation;insight;interest;Intervention;Knowledge;Literature;Malignant Childhood Neoplasm;Malignant Neoplasms;Maps;Medical;medication compliance;medication nonadherence;mHealth;mobile application;Modeling;Monitor;mortality;National Cancer Institute;novel;novel strategies;novel therapeutics;older adult;Oncology;oncology program;Outcome;patient engagement;Patients;Pharmaceutical Preparations;Phase;Pilot Projects;pilot test;Play;preference;Prevalence;Process;Professional Organizations;Protocols documentation;psychoeducation;Quality of life;Randomized;randomized, clinical trials;Recommendation;relapse risk;Research;response;Science;Site;standard of care;Standardization;Survival Rate;Techniques;Testing;theories;therapy design;therapy development;tool;treatment effect;Treatment Failure;Treatment Protocols;trial comparing;Tumor Biology;United States;Video Games

PROJECT_TITLE: A Pilot Feasibility Trial of a Tailored Intervention to Improve Adherence in Adolescents and Young Adults with Cancer

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Genetics

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative (Public Health Relevance) All cells in an organism share the same DNA but express different genes including variations of gene sequence at the level of RNA (isoforms) in a highly controlled manner that allows complex multicellular organisms to develop. Why RNA isoforms exist and how they are regulated and function is a foundational and unsolved problem in biology with broad implications for predicting and treating diseases. This proposal will continue experimental and computational research towards discovering new aspects of how and why RNA isoforms exist and how they can be used to predict and provide therapeutic targets for treating disease.

PI_NAMEs: SALZMAN, JULIA  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Alternative Splicing;Biological;Biological Markers;Biology;cell type;Cells;Complex;Coupled;Data;Development;digital;Disease;disease diagnostic;DNA;DNA Sequence;Drug Targeting;Eukaryota;Evolution;Generations;Genes;Genetic;Genetic Transcription;genetic variant;Genome;insight;Knowledge;novel;Nucleic Acids;Organism;Output;Pathogenicity;precision medicine;Process;Processed Genes;Protein Isoforms;Proteins;public health relevance;Regulation;Research;RNA;RNA Splicing;Statistical Data Interpretation;therapeutic target;Untranslated RNA;Validation;Variant

PROJECT_TITLE: Computational- and experimental- driven discovery of splicing regulation and circRNA function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


NIH_SPENDING_CATS: Asthma;Lung;Nutrition;Obesity

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Obesity associated asthma (OAA) is more severe and more difficult to treat than atopic asthma. Evidence suggests that these outcomes are due to OAA’s unique immunopathology and stem from obesity’s effects on lung macrophage activation and function. By identifying the lipid signals, metabolic pathways, and inflammatory machinery responsible for altered lung macrophage responses during obesity, this innovative project will provide important insights into OAA’s origins and identify targets for novel therapeutic development.

PI_NAMEs: HILL, DAVID ANDREW (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: Address;Adipose tissue;Adopted;Adult;airway inflammation;Asthma;Atherosclerosis;Biological Models;Bronchoalveolar Lavage;CASP1 gene;Cells;Characteristics;Childhood;Childhood Asthma;Clinical;Collaborations;Culture Techniques;Data;Deposition;Development;Event;Extrinsic asthma;Fatty Acids;Flow Cytometry;Future;Genetic;Grant;Human;Immune;Immune response;Immunologics;immunopathology;In Vitro;in vivo;Inflammasome;Inflammation;Inflammation Mediators;Inflammatory;inflammatory lung disease;innovation;insight;Interleukin-1 alpha;Knowledge;lipidome;lipidomics;Lipids;Lung;Macrophage;Macrophage Activation;Measures;Mediating;Metabolic;Metabolic Pathway;Metabolism;Modeling;mouse model;Mus;neutrophil;new therapeutic target;novel;Obese Mice;obese person;Obesity;Obesity associated disease;obesity-associated asthma;Outcome;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Population;Process;programs;Proteins;Publishing;Pulmonary Inflammation;Reporter;Resources;response;Risk;Sampling;Signal Pathway;Signal Transduction;Societies;Stearates;Steatohepatitis;stem;Stimulus;Structure of parenchyma of lung;targeted treatment;Techniques;Testing;Therapeutic;therapeutic development;Thinness;Tissues;TNF gene;transcriptome sequencing;transcriptomics;Translating;Work

PROJECT_TITLE: Impact of Obesity on Lung Macrophage Metabolism and Inflammation

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Clinical Research;Lymphatic Research;Orphan Drug;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE Lymphatic and venous malformations are slow-flow vascular malformations associated with severe morbidities and even mortality, but currently available treatments are all off-label and only provide partial response. We have identified protein synthesis and degradation defects in these malformations which contribute to the pathobiology and can be targeted therapeutically. We propose to target this defect by; 1) exacerbating the protein imbalance to cause cell death, or 2) rebalance synthesis and degradation to normalize the pathological cells and improve function.

PI_NAMEs: SHAWBER, CARRIE J. (contact);WU, JUNE KAR-MING

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Affect;alpelisib;Animal Model;Blood;Blood Coagulation Disorders;Blood Vessels;Bortezomib;Cell Death;Cell Physiology;Cell Separation;Cell surface;Cells;cellular engineering;Classification;Clinical;clinically relevant;Collaborations;Congenital Abnormality;Cytoplasm;Dangerousness;Data;Deep Vein Thrombosis;Defect;Degradation Pathway;Development;Dose;Drug Screening;efficacy evaluation;Endosomes;Endothelial Cells;Equilibrium;FDA approved;FRAP1 gene;Functional disorder;functional improvement;Genes;Genetic;genetic variant;Goals;Grant;Growth;Heart Diseases;Hemorrhage;Human;improved;In Vitro;Infection;KRAS2 gene;KRASG12D;Label;Lesion;Life;Link;Lymphatic;Lymphatic Endothelial Cells;lymphatic malformations;lymphatic vasculature;Lysosomes;malformation;Malignant Neoplasms;MAPK Signaling Pathway Pathway;Medical;Morbidity - disease rate;mortality;mosaic;mouse model;multicatalytic endopeptidase complex;novel drug class;novel therapeutics;overexpression;Pain;partial response;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;PECAM1 gene;Pharmaceutical Preparations;Phenocopy;PI3K/AKT;PIK3CA gene;PIK3CG gene;Principal Investigator;Production;programs;Proteasome Inhibition;Proteasome Inhibitor;Protein Biosynthesis;protein degradation;Proteins;proteostasis;proteostasis loss;Pulmonary Fibrosis;Ras/Raf;Reporting;Research;response;Risk;Role;Sepsis;Signal Transduction;Sirolimus;Somatic Mutation;success;targeted treatment;Therapeutic Intervention;therapeutic target;Transgenic Mice;Transgenic Organisms;treatment response;Variant;Vascular System;Venous;Venous Malformation;Xenograft Model

PROJECT_TITLE: Protein homeostasis dysfunction in LM and VM pathobiology and therapeutic responses


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: LAWRENCE

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: PROJECT NARRATIVE The mammalian anti-viral response utilizes several post-translational modifications (PTMs), like phosphorylation, to quickly alter signaling pathways or directly inhibit viral proteins. ADP-ribosylation is a PTM that controls the outcome of a coronavirus infection; however, little is known regarding how it restricts virus replication at a mechanistic level. The primary objective of this proposal is to identify ADP-ribosylated proteins during SARS-CoV-2 infection with the goal of developing a better understanding of the mammalian anti-viral response that will provide new avenues for anti-viral therapies.

PI_NAMEs: COHEN, MICHAEL S;FEHR, ANTHONY R (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;Address;Adenosine Diphosphate Ribose;ADP ribosylation;analog;Animal Model;Anti-viral Response;Anti-viral Therapy;Antibodies;Attenuated;Automobile Driving;Binding;Binding Sites;Biology;Cessation of life;chemical genetics;Chemicals;Chemistry;Complement;Coronavirus;Coronavirus Infections;COVID-19 outbreak;defense response;Development;Disease;enzyme activity;Enzymes;experimental study;Future;Genes;genetic approach;Goals;Host Defense;Human;human disease;in vivo;Individual;Infection;Innate Immune Response;innovation;interest;Interferon Type I;Interferons;knock-down;Knowledge;Label;Mediating;Methods;Murine hepatitis virus;Mutagenesis;mutant;Natural Immunity;Nicotinamide adenine dinucleotide;novel;Outcome;overexpression;pandemic disease;Pathogenesis;Phosphorylation;Photoaffinity Labels;Physiological;Play;Poly(ADP-ribose) Polymerases;Positioning Attribute;Post-Translational Protein Processing;protein expression;Proteins;Proteomics;Reporting;RNA Viruses;Role;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;Seminal;Signal Pathway;Signal Transduction;Site;Site-Directed Mutagenesis;System;Time;tool;Ubiquitination;Viral;Viral hepatitis;Viral Proteins;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Identifying the targets of virus-induced PARPs during SARS-CoV-2 infection

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The Neuroscience Colorado Research Experience (N-CORE) is an innovative summer research experience for undergraduate students from underrepresented backgrounds in the Denver Metropolitan and Regional area. N- CORE has forged a strong alliance with the Neuroscience Graduate Program at the University of Colorado Anschutz Medical Campus and will fulfill the goal of PAR-21-168 through a rigorous recruitment plan, an authentic research experience, a comprehensive education plan, and longitudinal mentoring. N-CORE fosters a community for like-minded students from similar backgrounds—a key component for retention of URM students in biomedical fields.

PI_NAMEs: RESTREPO, DIEGO ;SALCEDO, ERNESTO  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Area;Behavioral;Biomedical Research;Brain;career;Career Choice;career development;Career Mobility;Clinical Research;Colorado;Communication;Communities;community college;Counseling;crowdsourcing;Dedications;Development;disabled students;disadvantaged background;disadvantaged student;doctoral student;Education;education planning;education research;Eligibility Determination;Enrollment;Ensure;Environment;experience;Faculty;faculty mentor;First Generation College Students;forging;Fostering;Funding;Goals;graduate school;graduate student;Grant;Hispanic-serving Institution;Individual;innovation;Institution;Instruction;interest;Internships;Knowledge;knowledge base;Leadership;Medical;medical schools;Mentors;Mentorship;metropolitan;Mind;Neurosciences;Neurosciences Research;operation;Participant;Positioning Attribute;posters;pre-doctoral;programs;recruit;Reproducibility;Research;Research Training;Running;Science;skills;Students;success;summer internship;summer program;summer research;support network;symposium;Time;Training;Training Programs;translational neuroscience;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;work-study

PROJECT_TITLE: The Neuroscience Colorado Research Experience (N-CORE) - building a sustainable summer training research experience for undergraduate students from diverse backgrounds