ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE DEPT OF AGRIC/CONSUM SRVCS

PHR: LFFM Overall Component - Project Narrative This project will contribute to public health by preventing contaminated human food products from reaching consumers, removal of contaminated human food products, understanding risks to the human food supply, and developing risk-based strategies to control those risks. This project will strengthen and improve the collaboration of surveillance testing activities between the FDA and our state laboratory to continue building a nationally integrated laboratory science system. By strengthening and improving collaboration with the FDA, sample testing completed under this project will play a greater role in helping FDACS and FDA prevent contaminated products from reaching consumers, understand risks, and assess the value of strategies to control those risks.

PI_NAMEs: THOMPSON, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: WINTER, RONALD

PROJECT_TITLE: Florida Dept. of Agriculture Flexible Funding Food Chemistry/Microbiology


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: LEXINGTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Narrative The proposed research is relevant to public health because it focuses on discovery of novel signaling pathways that drive castration-resistant prostate cancer. These studies will establish new avenues of investigation to develop improved therapeutics to treat this deadly disease and to greatly improve patient outcome. Thus, the proposed research is relevant to NIH's mission of fostering creative discoveries and innovative research strategies for protecting and improving health and reducing the burdens associated with cancer.

PI_NAMEs: LIU, XIAOQI  (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: abiraterone;Acetates;Affect;Androgen Antagonists;androgen independent prostate cancer;Androgen Receptor;Androgens;Autocrine Communication;Biochemical;Bioinformatics;Cancer Patient;Castration;Cells;Clinic;Clinical;clinical translation;clinically relevant;Coculture Techniques;Creativeness;Cultured Cells;Data;Development;Disease;docetaxel;Drug usage;enzalutamide;Event;Fibroblasts;Fostering;gain of function;Genetically Engineered Mouse;Goals;Health;hormone therapy;Human;improved;inhibitor;inhibitor therapy;innovation;Investigation;loss of function;Malignant neoplasm of prostate;Malignant Neoplasms;Methodology;Mission;Modeling;Molecular;mouse model;Mus;Mutation;Neoplasm Circulating Cells;Neoplasm Metastasis;new therapeutic target;novel;novel strategies;Organoids;Outcome;Paracrine Communication;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;planar cell polarity;Play;prostate cancer cell;prostate cancer progression;Protein Family;Public Health;receptor;Receptor Activation;Receptor Signaling;Research;Resistance;response;RNA analysis;Role;Sampling;Signal Pathway;Signal Transduction;Specimen;System;Testing;Therapeutic;therapeutic target;Tissue Microarray;transcriptome;transcriptome sequencing;tumor;tumor microenvironment;United States National Institutes of Health;Withdrawal;WNT Signaling Pathway;Xenograft procedure

PROJECT_TITLE: Enhancing the efficacy of androgen signaling inhibitors in prostate cancer

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: ANN ARBOR

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Genome wide association studies (GWAS) have revolutionized the field of complex disease genetics. Intense efforts by large-scale international collaborations, including ours, have been successful in discovering key genetic variants robustly associated with bone mineral density (BMD) and fracture; however, GWAS only reports genomic signals associated with a given trait and does not necessarily identify culprit effector genes. Given the need for `variant to gene mapping', plus the need to expand the collection of public domain genomic data relevant to bone, we will build on our initial published results by utilizing our multi-step genomic analysis pathway and functional follow-up using siRNA and CRISPR in osteoblasts and osteoclasts and knockout mouse models to pinpoint causal gene(s) at key BMD and fracture GWAS-implicated locus.

PI_NAMEs: GRANT, STRUAN F A;HANKENSON, KURT DAVID (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Age Months;American;ATAC-seq;Bioinformatics;Biology;bone;Bone Density;Bone Diseases;bone geometry;bone loss;bone mass;Bone Resorption;causal variant;Cell Differentiation process;Cell Lineage;Cells;Child;Chromatin;chromosome conformation capture;Chromosome Mapping;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Collection;Communities;Complex;CRISPR/Cas technology;Data;Development;Disease;Enhancers;Etiology;Female;follow-up;Fracture;fracture risk;gene discovery;Gene Expression;Genes;Genetic;Genetic Diseases;genetic variant;Genome;genome wide association study;genome-wide;genomic data;Genomics;Goals;Grant;Human;In Vitro;in vivo;interest;International;Knockout Mice;Laboratories;Link;male;Mechanics;Methods;microCT;Minerals;Mission;Modeling;mouse model;Mus;novel;novel therapeutics;osteoblast differentiation;Osteoblasts;Osteoclasts;Osteogenesis;Osteoporosis;Pathogenesis;Pathway Analysis;Phenotype;Physiology;Play;prevent;Process;promoter;Public Domains;Publishing;Regulation;Reporting;Research;Resolution;Role;Sample Size;Sampling;Signal Transduction;Small Interfering RNA;Testing;Time;trait;transcriptome sequencing;Validation;Variant;Work

PROJECT_TITLE: Discovery of osteoblast and osteoclast bone mass effector genes using advanced genomics

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Heart Disease;Palliative Care

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: Project Narrative X Implantable cardioverter-defibrillators (ICDs) are commonly used in older patients with multiple co-morbidities. This project establishes a multi-center cohort study to prospectively define long-term experiences of older patients living with ICDs more than 5 years after initial implantation. We then apply mixed methods to evaluate the palliative and end-of-life experiences of patients who die despite the presence of an ICD.

PI_NAMEs: KRAMER, DANIEL BRUCE (contact)

PROGRAM_OFFICER_NAME: SIDDIQUI, AYESHA SAEED

PROJECT_TERMS: Advance Care Planning;Area Under Curve;Arrhythmia;Bereavement;Bioethics;Cardiac;cardiometabolism;Caregivers;Caring;Cause of Death;Cessation of life;Clinical;Cognition;cohort;Cohort Studies;Collaborations;comorbidity;Complement component C6;Data;Data Sources;Decision Making;Devices;Elderly;Electronic Health Record;end of life;end of life care;end of life outcomes;Enrollment;evidence base;experience;Family;Foundations;frailty;functional status;Geriatric Assessment;Geriatrics;Goals;Guidelines;health care service utilization;health service use;Health Status;Heterogeneity;hospice environment;human old age (65+);Impaired cognition;Implant;Implantable Defibrillators;implantation;Implantation procedure;improved;individual patient;innovation;Intervention;Interview;Investigation;Knowledge;Life;Life Experience;Measures;Methods;Modeling;mortality;novel;older patient;Outcome;Outcomes Research;Pain;palliative;Palliative Care;Patient Care;patient oriented;Patient risk;Patients;Performance;personalized predictions;Persons;Physical activity;Pilot Projects;prospective;Prospective cohort;Prospective Studies;Proxy;Quality of life;Registries;remote monitoring;Research;Resources;Risk;satisfaction;Services;Shock;Site;Symptom Burden;Telephone;Vulnerable Populations;Work

PROJECT_TITLE: Prospective Investigation of Palliative and End-of-Life ExpeRiences with ICDs (PIPER-ICD) Study

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: LOS ANGELES

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Continuing advances in the facile generation of comprehensive analysis of individual genomes, transcriptomes and epigenomes has profoundly accelerated our ability to identify the genetic cause or rare diseases. With this transformative capability, there is a rapidly expanding need for expertise in genetics at the clinical, biochemical, cellular, molecular and informatics levels that are integrated into impact of individuals with rare and common diseases. This T32 training program will recruit and train young scientists and physicians to facilitate meaningful research into the causes, prevention and treatment of genetic diseases, become adaptable leaders in this rapidly evolving area of medicine.

PI_NAMEs: MARTINEZ-AGOSTO, JULIAN  (contact);NELSON, STANLEY F.

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Medical Genetics;Training Programs

PROJECT_TITLE: UCLA Medical Genetics Training Program


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: CHEMISTRY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: PROJECT NARRATIVE Molecular chaperones maintain protein homeostasis in cells by facilitating protein folding, translocation, and degradation. They exist in multiprotein complexes to regulate cellular processes such as cell signaling, DNA repair, and more recently, cell metabolism. The proposed studies aim to understand how these chaperone complexes recruit and act on metabolic enzymes to meet the increased demand brought on by reprogramming events that contribute to human disease progression.

PI_NAMEs: PEDLEY, ANTHONY M (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Anabolism;Autophagocytosis;Biochemical;Biomass;Cell Physiology;Cells;Cellular Metabolic Process;Complex;Coupled;Disease;Disease Progression;DNA Repair;Ensure;Enzymes;Event;Fluorescence Microscopy;Glycolysis;Human;human disease;insight;Knowledge;malignant neurologic neoplasms;Mediating;Metabolic;Metabolic Pathway;Molecular;Molecular Biology;Molecular Chaperones;Multiprotein Complexes;Nervous System Disorder;novel therapeutic intervention;Nutrient availability;Phase;Predisposition;Proliferating;protein folding;Proteins;Proteome;Proteomics;proteostasis;Purines;recruit;Regulation;Signal Transduction;tool;ultra high resolution

PROJECT_TITLE: Molecular Chaperone-mediated Regulation of Cell Metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(55)R]


ADMINISTERING_IC: FD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: REYNOLDSBURG

ORG_NAME: OHIO STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: OH

PHR: Ohio’s Project Narrative The Ohio Department of Agriculture (ODA) implementation of FDA’s Animal Food Regulatory Program Standards will help improve our states efforts to protect Ohio’s and the U.S. animal food supply. The funding this grant offers will allow ODA to complete the objectives outlined in the statement of work.

PI_NAMEs: HOLTON, CHRIS  (contact)

PROGRAM_OFFICER_NAME: LOWE, SHANNON

PROJECT_TITLE: Ohio Department of Agriculture AFRPS


NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Disability Research;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: PORTLAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Narrative This project will determine whether objective measures of walking and turning quality from 7 days of daily life activity using wearable sensors is more sensitive to early disease state, disease progression, quality of life and fall risk in people newly diagnosed with PD, than current clinical measures. Disease progression using digital measures of walking and turning will be compared with clinical measures, patient-reported measures and fall diaries in 100 people with PD and 50 elderly control subjects, tested yearly for 3 years. Identification of the most sensitive measures of mobility disability progression during real life activities with wearable technology will provide novel outcome measures for clinical trials testing the effectiveness of new disease-modifying therapies and improve the timing of clinical interventions for patients.

PI_NAMEs: MANCINI, MARTINA  (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Affect;Algorithm Design;Characteristics;Clinic;Clinical;clinical decision-making;clinical outcome measures;clinical practice;Clinical Trials;Collaborations;Communities;Complex;Data;Data Analyses;Development;Diagnosis;diaries;Digital biomarker;digital measure;Disease;Disease Marker;disease phenotype;Disease Progression;effectiveness testing;Elderly;Environment;Equilibrium;Evaluation;Expert Opinion;fall risk;falls;foot;Functional disorder;Future;Gait;Home;Idiopathic Parkinson Disease;improved;instrument;Intervention;Laboratories;Life;Linear Regressions;Measures;Methods;Mobility decline;Mobility disability;Modeling;Motor;Movement Disorder Society Unified Parkinson's Disease Rating Scale;multitask;Neurodegenerative Disorders;Neurologist;neuroprotection;neuroregulation;Newly Diagnosed;novel;Outcome;Outcome Measure;Parkinson Disease;Participant;Patient Outcomes Assessments;Patients;Performance;Persons;Posture;prevent;Prognosis;prospective;Quality of life;Reporting;sensor;sensor technology;Severity of illness;sex;Testing;Time;Tremor;Walking;wearable device;wearable sensor technology

PROJECT_TITLE: Digital Markers of Mobility in Daily Life to Track Progression in Newly Diagnosed Parkinson's Disease

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Narrative Hazardous metals in drinking water, which are common contaminants near Superfund sites and abandoned uranium mines, play a role in the high burden of heart disease and diabetes affecting rural communities in the US Northern Plains, including tribal communities. The Columbia University Northern Plains Superfund Research Program (CUNP-SRP) will generate new knowledge to understand the underlying mechanisms and possible solutions to exposures to hazardous metal mixtures using systems science, local community knowledge, and novel remediation technology. CUNP-SRP partnership and activities will be facilitated by our integrated approaches, the central role of the communities, strong institutional support, and our team’s successful experience working together on translational science relevant for Superfund sites, which together will enable us to lay the groundwork for effective interventions to reduce potentially hazardous drinking water contamination.

PI_NAMEs: NAVAS-ACIEN, ANA  (contact)

PROGRAM_OFFICER_NAME: CARLIN, DANIELLE J

PROJECT_TERMS: Address;Adsorption;Adult;Affect;Area;Arizona;Arsenic;Biological;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;Chemistry;Cheyenne;Childhood;citizen science;Collaborations;Communities;community engagement;Community Outreach;community partners;complex data;Conceptions;Congresses;contaminated drinking water;Data;Data Analyses;data management;Diabetes Mellitus;Dietary Intervention;disorder prevention;Distal;drinking water;early life exposure;effective intervention;Elements;Ensure;Environment;Epidemic;Epidemiology;epigenomics;Etiology;evidence base;Excision;experience;Exposure to;Fractionation;Government;ground water;hazardous drinking;Hazardous Waste Sites;Health;Heart;Heart Diseases;Household;Human;Indigenous;innovation;innovative technologies;Institution;Intervention;Isotopes;Joints;Knowledge;Laboratories;Life;Light;Longitudinal Studies;Maintenance;Measurement;Measures;metabolomics;Metal exposure;Metals;Modeling;Molecular;Molecular Profiling;Monitor;mouse model;multiple omics;Mus;Native Americans;New Mexico;next generation;northern Native American;Northern Plains;novel;Nutritional status;Oxidation-Reduction;Pathway interactions;photosynthetic bacteria;Policies;Population;Prevention;Privatization;Program Research Project Grants;programs;Recycling;remediation;Research;Research Activity;Research Design;Research Ethics;Resolution;Risk Reduction;Role;Rural;Rural Community;Sampling;Science;Scientist;Signal Recognition Particle;Sioux Indians;Source;South Dakota;Specimen;stable isotope;success;Superfund;superfund site;synergism;System;Techniques;Technology;Tissue Sample;Tissues;Toxic effect;toxic metal;Training;transcriptomics;Translational Research;Treatment Failure;tribal community;tribal lands;Tribes;United States Indian Health Service;Universities;Uranium;urinary;Urine;wasting;Water;water quality;water sampling;well water

PROJECT_TITLE: Columbia University and Northern Plains Partnership for the Superfund Research Program


NIH_SPENDING_CATS: American Indian or Alaska Native;Bioengineering;Clinical Research;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PHR: Project 1 Narrative There is a lack of groundwater data in Northern Plains Native American tribal communities despite groundwater being the most likely source of exposure contributing to high urinary arsenic and uranium levels in these communities. Project 1 will merge new measurements of drinking water quality with existing spatial datasets to develop process-based models that predict contaminant concentrations at the household scale across Northern Plains tribal sites. The results, together with evaluations of temporal changes in drinking water concentrations from prior policy interventions and development of drinking water exposure profiles for the study cohort, will enable the development and establishment of effective interventions to reduce these potentially hazardous exposures to contaminated drinking water in the Northern Plains and beyond.

PI_NAMEs: CHILLRUD, STEVEN N. (contact)

PROJECT_TERMS: Address;Affect;anthropogenesis;Area;Arsenic;Cardiometabolic Disease;Chemicals;Cheyenne;cohort;Cohort Studies;Communities;community engagement;contaminated drinking water;cooking;Dangerousness;Data;Data Analyses;Data Collection;Data Set;density;Development;drinking;drinking water;effective intervention;Environmental Exposure;Environmental Pollution;Environmental Risk Factor;Epidemic;Evaluation;Exposure to;Filtration;Future;geochemistry;Goals;ground water;hazard;Health;Heart;Household;hydrology;improved;Individual;interest;Intervention;Isotopes;Length;Location;machine learning model;machine learning prediction;Measurement;Measures;member;Metal exposure;Metals;meter;Methods;Modeling;Native American Tribe;Nitrates;northern Native American;Northern Plains;Northern Plains Tribe;oxidation;Oxidation-Reduction;Participant;Pathway interactions;Policies;Population;Populations at Risk;predictive modeling;Privatization;Probability;Process;programs;Publications;Recording of previous events;remediation;remote sensing;Research;Resolution;Resources;Role;Running;rural area;Rural Community;Sioux Indians;Site;Source;South Dakota;Southeastern Asia;Spatial Distribution;Superfund;Surface;Surveys;System;Testing;Time trend;Toxicology;trend;tribal community;Tribes;Universities;Uranium;urinary;Water;water quality;Water Supply

PROJECT_TITLE: High Resolution Models of Groundwater Metal Exposures


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Prevention;Primary Health Care;Recovery Support Services;Rehabilitation;Social Determinants of Health;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Most patients who begin buprenorphine treatment for opioid use disorder (OUD) discontinue within the first 6 months, which substantially elevates their risk of relapse, overdose, morbidity and mortality. Peer Recovery Specialists (PRS) are individuals in recovery who can provide emotional support to patients with OUD, motivate behavior change and help patients overcome the situational barriers to treatment retention. The proposed research has three aims: 1) identify the structures, functions, resources and practices of a diverse set of primary care PRS programs and their potential for increasing patient retention in OUD treatment; 2) with a planning group of community stakeholders and OUD, peer and implementation experts, develop an optimized model of PRS support services; and 3) pilot test the model with a small sample of patients with OUD in a primary care practice, and assess the feasibility and acceptability of the intervention and the fidelity and sustainability of its implementation.

PI_NAMEs: HARRIS, REBECCA ARDEN (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: acceptability and feasibility;Adherence;Adult;Affect;Age;Area;arm;barrier to care;Behavior;behavior change;Behavior Therapy;Buprenorphine;buprenorphine treatment;career;Caring;Characteristics;Clinic;Clinical;collaborative care;Combination Medication;Communities;community intervention;comorbidity;Coping Skills;cost effective;Counseling;Data;Data Collection;Development;Disease;Dose;Dropout;Educational Curriculum;effectiveness evaluation;Elements;Emotional;Empathy;Environment;ethnic minority population;Ethnic Origin;evidence base;Evidence based treatment;examination questions;experience;feasibility testing;flexibility;Foundations;Frequencies;Future;Goals;Health;Health education;Health system;healthcare community;implementation facilitators;improved;improved outcome;Incentives;Individual;Institution;Intervention;Interview;Logistics;Low income;male;Measures;medication-assisted treatment;Medicine;member;Mental Health;Methadone;Methods;Modeling;Morbidity - disease rate;mortality;motivated behavior;National Institute of Drug Abuse;novel;operation;Opioid;opioid use disorder;Overdose;overdose death;participant enrollment;Patient Dropouts;patient oriented;patient retention;Patient-Focused Outcomes;Patients;peer;peer recovery;peer support;Pennsylvania;Perception;Persons;Pharmaceutical Preparations;Philadelphia;Physicians;pilot test;polysubstance use;Positioning Attribute;Preparation;Prevention;Primary Care;primary care clinic;primary care practice;primary care setting;Process;programs;Qualifying;Questionnaires;racial minority;racial minority population;Randomized, Controlled Trials;Recovery;Recovery Support;recruit;relapse risk;Research;Resources;Sampling;Schedule;Scientist;service delivery;Services;sex;Site;skills;social stigma;socioeconomics;Specialist;Strategic Planning;Structure;success;Supervision;Surveys;Testing;therapy design;Toxic effect;Training;Training Programs;Unemployment;Universities;Variant;whole health;Work

PROJECT_TITLE: Reducing OUD treatment dropout: Development and pilot test of a peer recovery support intervention in primary care

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: American Indian or Alaska Native;Clinical Research;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research

PHR: Project 2 Narrative Project 2 of the Columbia University Northern Plains Superfund Research Program (CUNP-SRP) will develop the spatial and temporal distribution of uranium and selenium isotope ratios or “isoscapes,” from private groundwater wells, which will reveal the sources and mechanisms of hazardous metal cycling in the aquifers, and the evolution of existing uranium and selenium plumes. This study will also develop the use of isotope ratios as novel biomarkers of uranium and selenium exposure in humans linked to an environmental source. Our results will reduce risk from contamination, support monitoring and management of contaminated aquifers, and identify exposures using a non-invasive diagnostic tool for Native Americans.

PI_NAMEs: HALLIDAY, ALEX  (contact)

PROJECT_TERMS: Adsorption;Affect;aqueous;Area;Arsenic;Biological Markers;Cardiometabolic Disease;Characteristics;Chemicals;Chemistry;Cheyenne;Communities;Community Surveys;Data;Deposition;Development;diagnostic tool;Distal;drinking;drinking water;Elements;Environment;Environmental Exposure;Environmental Impact;Environmental Pollution;Epidemic;Evolution;Excision;exposed human population;Exposure to;Fractionation;geochemistry;Geographic Distribution;ground water;Heart;Human;Human body;human data;Immobilization;Intervention;Ions;Isotopes;Light;Link;Maps;Measurement;Measures;Metal exposure;Metals;Methods;mineralization;Minerals;Mining;Modeling;Monitor;Mus;Native American community;Native Americans;noninvasive diagnosis;North Dakota;Northern Plains;novel;novel marker;Organ;oxidation;Oxidation-Reduction;Pattern;Play;Population;Precipitation;Privatization;Process;programs;Reaction;remediation;Research;Reservations;Resolution;Risk;Risk Reduction;Role;Rural Community;Safety;Sampling;Selenium;Sioux Indians;Site;Solid;Source;South Dakota;Spatial Distribution;Superfund;Testing;Time trend;Tissue Sample;Tissues;tool;Trace Elements;Tracer;tribal community;tribal lands;Tribes;Universities;uptake;Uranium;urinary;Urine;Water

PROJECT_TITLE: Isotopic Tracing of Sources and Cycling of Hazardous Metal Mixtures


NIH_SPENDING_CATS: American Indian or Alaska Native;Cardiovascular;Clinical Research;Foodborne Illness;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Human Genome;Prevention;Racial and Ethnic Minority Health Research;Rural Health

PHR: Narrative of Project 3 Arsenic and uranium are major contaminants at Superfund sites, and exposure to these contaminants can partly explain the excess burden of cardiometabolic disease affecting Native American communities in the US. Project 3 will determine the effect of past and current metal exposures in cardiometabolic disease and their longitudinal epigenetic and metabolomic signatures. This study can then reveal molecular mechanisms for metal-induced health effects, identify susceptible populations, and inform risk assessment with direct benefits for the prevention and control of metal exposure and cardiometabolic disease affecting tribal communities in the US Northern Plains as well as other at-risk populations globally.

PROJECT_TERMS: Address;Adult;Affect;Area;Arsenic;Biological Markers;Blood;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;Childhood;Clinical Data;cohort;Communities;community partners;Congresses;contaminated water;Data;data integration;design;Diabetes Mellitus;diabetes risk;Dietary Intervention;Disease;disorder risk;DNA Methylation;drinking water;effective intervention;epidemiologic data;Epigenetic Process;epigenomics;Ethnic Population;Etiology;Excision;experience;Exposure to;Family;Family Study;Fingerprint;Funding;General Population;genome-wide;Genotype;ground water;Health;Heart;Individual;innovation;Intervention;Isotopes;Joints;Link;Machine Learning;Measures;Mediation;metabolomics;Metal exposure;Metals;Modification;Molecular;Monitor;Mothers;Multiomic Data;multiple omics;Mus;National Heart, Lung, and Blood Institute;Native American community;Native American population;Native Americans;Northern Plains;Nutritional status;Occupational;offspring;Outcome;Participant;Pathway interactions;Pattern;Phenotype;Plasma;Population;Populations at Risk;Predisposition;Prevention;programs;racial population;recruit;Research;Risk Assessment;Risk Factors;Risk Reduction;Schedule;sex;Site;Source;spatiotemporal;stable isotope;Subgroup;Superfund;superfund site;Time trend;Tissues;trend;tribal community;tribal lands;Universities;Uranium;urinary;Urine;Visit;wasting;Water;Water Pollutants

PROJECT_TITLE: Health Effects of Metals in Native American Communities: A Longitudinal Multi-omics Study


NIH_SPENDING_CATS: American Indian or Alaska Native;Cardiovascular;Foodborne Illness;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Prevention;Racial and Ethnic Minority Health Research

PHR: Project 4 Narrative Arsenic and uranium are major contaminants at Superfund sites, and exposure to these contaminants can partly explain the excess burden of cardiometabolic disease affecting Native American communities in the US. Project 4 will determine the physiological and molecular pathways linking arsenic and uranium exposures to cardiometabolic disease phenotypes using tractable transgenic mouse models. This study provides detailed and expansive insight into the developmental and life-long influences of these metals exposures and create a novel experimental system to test interventions to protect highly exposed populations in the US Northern Plains.

PI_NAMEs: PEARSON, BRANDON L (contact)

PROJECT_TERMS: Adult Children;Affect;Alleles;Animal Model;animal tissue;Apolipoprotein E;Arsenic;Atherosclerosis;Behavioral;biobank;Biological Markers;Biological Models;Blood;Body System;burden of illness;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;Cardiovascular system;cell type;Chemicals;Chronic;Chronic Disease;Clinical;cohort;Collaborations;Communities;community engagement;Consumption;contaminated drinking water;Data;data modeling;Development;Developmental Toxicant;Diabetes Mellitus;diabetes risk;dietary;Dietary Factors;Dietary Intervention;disease phenotype;DNA Methylation;drinking water;early life exposure;efficacy evaluation;Elements;Environment;Epidemiology;Epigenetic Process;Experimental Animal Model;Exposure to;Folic Acid;folic acid supplementation;Future;Gene Expression;gene function;Genetically Engineered Mouse;ground water;Half-Life;Health;Heart;Histologic;Human;humanized mouse;Hypertension;Immunologics;improved;Individual;Inflammation;insight;intergenerational;Intervention;Knowledge;Laboratory mice;Life;lifestyle factors;Link;Liver;Mediator;Metabolic;Metabolism;metabolome;metabolomics;Metal exposure;Metals;Methylation;Modeling;Modification;Molecular;molecular marker;Molecular Profiling;Monitor;mouse model;multiple omics;Mus;mutant;Native American community;Native Americans;Northern Plains;novel;Obesity;Observational Study;Organ;Outcome;Pancreas;Participant;Pathogenicity;Pathology;Pathway interactions;Persons;Physiological;Population;Predisposition;prevent;preventive intervention;programs;Relative Risks;Research;Research Project Grants;Resources;response;Risk;Role;Sampling;Science;screening;Signal Recognition Particle;Site;South Dakota;Superfund;superfund site;System;Testing;therapeutic evaluation;Therapeutic Intervention;Tissues;tool;Toxic effect;Toxicology;transcriptomics;Transgenic Mice;Tribal group;Universities;Uranium;urinary;Urine;Water;water sampling;waterborne;well water

PROJECT_TITLE: Causal Molecular Mechanisms Linking Drinking Water Metal Exposures to Cardiometabolic Disease


NIH_SPENDING_CATS: American Indian or Alaska Native;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: Project 5 Narrative Exposure to arsenic and uranium in drinking water—common contaminants at Superfund sites and on tribal lands in the Northern Plains—is associated with negative health effects, including high rates of cardiometabolic disease. Project 5 will address shortcomings in water remediation that often lead to incomplete removal of groundwater metal contaminants, including arsenic and uranium, by developing new light-based strategies that enhance efficiency and system lifetime. Once validated, our long-term goals are to implement this effective yet sustainable remediation methodology through partnership with the Native American-owned research firm Missouri Breaks Industries Research, Inc., to reduce potentially harmful exposures to drinking water contamination in the Northern Plains and provide proof-of-concept for implementation in other regions.

PI_NAMEs: BOSTICK, BENJAMIN C (contact)

PROJECT_TERMS: Address;Adoption;Adsorption;Affect;American;Animal Model;aqueous;Area;Arsenic;Bacteria;Carbon;Cardiometabolic Disease;Catalysis;catalyst;Chemicals;Communities;community engagement;Consumption;contaminated drinking water;contaminated water;cost;Detection;Development;Disease;drinking water;Ensure;Excision;Exposure to;Filtration;Generations;geochemistry;Goals;ground water;Health;Human;improved;Industry;Intervention;Iron;iron oxide;Light;Longevity;Maintenance;Manganese;Measures;Metals;Methodology;Methods;microbial;microbial community;microorganism;Minerals;Mission;Missouri;Monitor;Native American population;Native Americans;Natural regeneration;Nitrates;North Dakota;Northern Plains;novel;Outcome;oxidation;Oxides;Pathway interactions;Pattern;Performance;Persons;Phase;pilot test;Population;Populations at Risk;prevent;Privatization;Process;Production;programs;Public Health;Recycling;remediation;Research;rural area;Rural Community;Sioux Indians;Site;Source;South Dakota;Specific qualifier value;Specificity;stem;Superfund;superfund site;System;Technology;Testing;Time;Treatment Efficacy;treatment site;tribal lands;Universities;Uranium;Variant;Water;Water Pollutants;water quality;water sampling;Water Supply;water testing;water treatment;well water

PROJECT_TITLE: Light-Based Approaches to Effective and Sustainable Removal of Arsenic and Uranium from Drinking Water Sources


NIH_SPENDING_CATS: American Indian or Alaska Native;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PHR: Administrative Core - Narrative The Administrative Core serves as the central resource of the Columbia University Northern Plains Superfund Research Program (CUNP-SRP), a new center that will establish a partnership between scientists and tribal communities to advance science and technology to address groundwater contaminants and their related health effects in the Northern Plains. The Core will foster interdisciplinary collaboration, promote research translation, and facilitate career development of early-stage investigators, together ensuring that activities of the CUNP-SRP are both relevant and impactful. The Administrative Core will integrate Projects and Cores to ensure that the CUNP-SRP contributes to effective strategies to monitor water contaminants, facilitate their remediation, and mitigate their health effects in the target communities, at other contaminated Superfund sites, and for other at- risk populations.

PROJECT_TERMS: Address;Advisory Committees;Affect;Arsenic;Award;Budgets;Businesses;career;career development;Cheyenne;Collaborations;commercialization;Communication;Communities;community collaboration;community engagement;Community Participation;community partners;contaminated water;Data Analyses;Data Collection;data management;Decision Making;Development;Dietary Intervention;Doctor of Philosophy;drinking water;Elements;Ensure;Epidemiologist;Etiology;Evaluation;Event;experience;Exposure to;Federal Government;Fostering;Geological Survey;Government;Government Agencies;ground water;Hazardous Chemicals;Health;Hybrids;Information Dissemination;interdisciplinary collaboration;Interdisciplinary Communication;interest;International;Intervention;investigator-initiated translational research;Isotopes;Joints;Journals;Lead;Leadership;meetings;Mentors;Metals;Methods;Mission;Modeling;multiple omics;National Institute of Environmental Health Sciences;Native American community;Native Americans;Natural Resources;NIH Program Announcements;Northern Plains;novel;Occupational activity of managing finances;outreach;Oxidation-Reduction;Physicians;Policies;Policy Developments;Population;Populations at Risk;Press Releases;Prevention;Privatization;Productivity;programs;Progress Reports;Public Health;Publications;Qualitative Evaluations;Quantitative Evaluations;remediation;Reporting;Research;Research Design;Research Personnel;Research Support;Resources;response;Risk Assessment;Science;Scientist;Signal Recognition Particle;Sioux Indians;Site;social media;Specialist;State Government;Statutes and Laws;Strategic vision;Structure;success;Superfund;superfund site;System;Technology;Technology Transfer;Testing;Tissues;Trace Elements;Training;Translational Research;Translations;tribal community;tribal lands;tribal leader;tribal Nation;tribal organization;Tribes;United States Indian Health Service;Universities;Uranium;Water;Water Pollutants;water testing;web site;webinar;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: American Indian or Alaska Native;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Rural Health

PHR: Narrative The DMAC will collaborate with CUNP-SPR Project investigators and our partnering communities in the Northern Plains to ensure that all relevant data are clearly organized, well documented, easily accessible and respectful of all aspects of tribal data sovereignty. A user-friendly DMAC web portal on the CUNP-SRP website will allow users with different security levels – public, CUNP-SRP investigators, trainees, and administrators – to search, view, enter, or edit data on individual databases as appropriate. The DMAC will support the application of existing methods and the development of new methods for analysis in service of the CUNP-SRP’s goals, take steps to ensure the reproducibility of all findings, and create educational resources for investigators, trainees, citizen scientists, and community members.

PI_NAMEs: GOLDSMITH, JEFF  (contact)

PROJECT_TERMS: Administrator;Adopted;Agreement;analysis pipeline;Biological Markers;Biological Sciences;citizen science;Code;Collaborations;Collection;Communication;Communities;community engagement;community partners;Complex;complex data;Computer Security;Computer software;Data;data access;Data Analyses;Data Collection;data communication;data harmonization;data integration;data interoperability;data management;data mining;data quality;data resource;Data Science;Data Set;data sharing;Databases;Dedications;Development;Directories;Doctor of Philosophy;Earth science;Education;education resources;Educational workshop;Electronics;Ensure;experience;Fostering;Geoscience;Goals;Health;Health Sciences;Heart;high dimensionality;improved;Individual;Information Systems;Infrastructure;innovation;interoperability;Lead;machine learning method;meetings;member;method development;Methods;Mission;multidimensional data;Needs Assessment;Northern Plains;Ontology;operation;Outcome;outreach program;Ownership;Performance;physical model;Planet Earth;Policy Making;Positioning Attribute;Procedures;Process;programs;Protocols documentation;public database;quality assurance;Quality Control;remote sensing;Reporting;repository;Reproducibility;Reproducibility of Results;Research;Research Design;Research Personnel;Resources;Science;searchable database;Security;Services;Signal Recognition Particle;Source;Specialist;Specific qualifier value;Statistical Methods;Statistical Models;Superfund;Synchrotrons;System;Techniques;Technology;Testing;Time trend;tool;Training;Translations;trend analysis;tribal community;Tribes;United States Indian Health Service;Universities;user friendly software;user-friendly;Visualization;Water Pollutants;water quality;web based interface;web page;web portal;web site;Work

PROJECT_TITLE: Data Management and Analysis Core


NIH_SPENDING_CATS: American Indian or Alaska Native;Clinical Research;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Rural Health

PHR: Community Engagement Core (CEC) Narrative The Community Engagement Core (CEC) of the Columbia University Northern Plains Superfund Research Program (CUNP-SRP) is a collaboration among Columbia University researchers, Missouri Breaks Industries Research, Inc. (a Native American-owned research firm), a Community Advisory Committee, and numerous local stakeholders striving to mitigate drinking water metal exposure and disease in rural tribal communities in the Northern Plains through community outreach and education. The CEC aims to decrease metal exposure and related disease in tribal communities using a bidirectional participatory approach that improves access to high- quality drinking water resources and promotes healthy traditional diets that improve nutritional status and can prevent cardiometabolic diseases. Central to this approach are the core values of equal participation in science and a commitment to safeguarding tribal sovereignty and the rights of citizens and communities, which are transferable to additional Superfund sites, the Superfund Research Program in general, and more broadly to improve public health.

PI_NAMEs: O'LEARY, MARCIA  (contact)

PROJECT_TERMS: Advocacy;Affect;anthropogenesis;Arsenic;Cardiometabolic Disease;cardiometabolism;citizen science;Collaborations;Communication;Communities;community advisory board;community engagement;Community Health Education;Community Outreach;Community Participation;Data;Data Analyses;data management;data sharing;Diet;Dietary Intervention;Disease;disorder prevention;Doctor of Philosophy;drinking water;Education and Outreach;Educational Materials;Educational workshop;Elderly;Elements;Ensure;Environment;environmental chemical;Equilibrium;evidence base;experience;Exposure to;Feedback;Goals;Government;ground water;hazard;Health;Heart;High School Student;Impact evaluation;Improve Access;improved;indigenous community;Industry;Intervention;Knowledge;Lead;Leadership;Maps;member;Metal exposure;metal poisoning;Metals;Mission;Missouri;Native American population;Native Americans;North Dakota;Northern Plains;Northern Plains Tribe;novel;Nutritional;Nutritional status;Outcome;Planet Earth;Play;prevent;Prevention education;Prevention strategy;Printed Media;Privatization;Process;Program Research Project Grants;programs;Prospective, cohort study;Public Health;remediation;Research;Research Activity;Research Personnel;Research Priority;Resources;Rest;Rights;Risk;Risk Factors;Role;Rural;Rural Community;rural environment;sample collection;Science;Scientist;Signal Recognition Particle;Site;social media;Source;South Dakota;Superfund;superfund site;symposium;System;teacher;technological innovation;Technology;Toxic effect;toxic metal;treatment strategy;tribal community;tribal Nation;Tribes;Universities;Uranium;Visualization software;Vitamin B Complex;Water;Water Pollutants;water quality;water sampling;Work

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: American Indian or Alaska Native;Data Science;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health

PHR: RETCC Narrative The Research Experience and Training Coordination Core (RETCC) will train a diverse group of future leaders who can traverse biomedical and earth sciences research to accelerate innovation, incorporate community input, and improve public health. The Columbia University Northern Plains Superfund Research Program’s mission to advance science and technology to improve water quality and mitigate metal-related health effects in tribal communities in the Northern Plains uses systems science, local community knowledge, and cross-cutting technologies which will provide an ideal framework for this interdisciplinary research and training. Successful accomplishment of the proposed aims will yield alumni who are proficient in their chosen disciplines and in interdisciplinary research, with real-world perspectives, a strong set of practical skills, respect for communities, and leadership qualities that will enable them to launch their careers as successful environmental health and earth scientists and engineers.

PROJECT_TERMS: Acceleration;Address;Admission activity;Affect;Area;career;college;Communication;Communities;community engagement;contaminated water;Creativeness;Data;Data Analyses;data management;Data Science;Data Scientist;design;Development;Discipline;diversity and inclusion;Doctor of Philosophy;Earth science;Education;Educational Curriculum;Educational workshop;Eligibility Determination;Engineering;Environmental Health;experience;Feedback;Fostering;Future;Goals;Government;graduate student;ground water;hands on research;Health;Health Sciences;High School Student;improved;Indigenous;Inequity;innovation;Interdisciplinary Study;interest;Journals;Knowledge;Laboratories;Laboratory Research;Lead;Leadership;Learning;Link;Medicine;member;Mentors;Metals;Mission;Molecular;multidimensional data;Native Americans;Northern Plains;Ownership;peer;peer networks;Planet Earth;Policies;Postdoctoral Fellow;Program Research Project Grants;programs;Public Health;Public Health Schools;real world application;recruit;Research;Research Ethics;Research Personnel;Rural Community;Science;Science, Technology, Engineering and Mathematics Education;Scientist;Signal Recognition Particle;skills;Source;statistical and machine learning;student training;Students;suburban communities;Superfund;superfund site;support network;System;Technology;Time;Training;Training Programs;Translational Research;Translations;tribal community;tribal organization;Tribes;United States National Institutes of Health;Universities;Vocabulary;Water Pollutants;water quality;web site;Work


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Despite having powerful tools to engineer a wide range of animal models and drug delivery to better understand tissue response to injury and treatment, the missing opportunities of tracking cell dynamics in their natural environment are significant. This project addresses the need for in vivo volumetric imaging systems capable of progressively tracking the dynamics of cells from deep tissue layers in a single specimen. The accomplishment of this project will offer new paradigms of fast volumetric imaging in multimodal imaging systems for biomedical applications.

PI_NAMEs: TANKAM, PATRICE  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: Acceleration;Acoustics;Address;Adoption;Affect;Animal Model;arm;biomaterial compatibility;Biomedical Research;cell behavior;Cell Physiology;Cells;Compensation;confocal imaging;design;Detection;Development;Devices;Drug Delivery Systems;Engineering;Environment;Extracellular Matrix;flexibility;Fluorescence;Fluorescence Microscopy;Frequencies;Genetically Modified Animals;Goals;Image;imaging capabilities;imaging modality;imaging system;Imaging technology;in vivo;in vivo fluorescence;in vivo imaging;Individual;interest;Investigation;Label;Lateral;lens;Light;Measurement;meter;Methods;Microscopy;Microspheres;Multimodal Imaging;multimodality;nanoparticle drug;novel;Optical Coherence Tomography;Optics;Outcome;Pathogenicity;Performance;Positioning Attribute;Reproducibility;Research;research facility;Resolution;response to injury;Sampling;Scanning;Science;Silicon;Specimen;System;Techniques;Technology;temporal measurement;Thick;Time;Tissues;tool;Transgenic Mice;two photon microscopy;Variant

PROJECT_TITLE: Concurrent volumetric imaging with multimodal optical systems


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: DURHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Relevance statement With the extraordinary progress made in the past 13 years, we expect that in the next 7 years, we will be able to complete the development of safe strategies for enhancement of bnAb lineage germinal center B cell and T follicular cell (Tfh) responses for induction of bnAbs, and design and implement strategies for induction of NNAbs that broadly protect by ADCC or other Fc receptor (FcR)-mediated immune responses. Once iterative Phase I trials are completed that demonstrate safe and durable induction of bnAbs and/or protective NNAbs, then the way will be paved for a successful Phase III efficacy trial of an efficacious global HIV-1 vaccine.

PI_NAMEs: HAYNES, BARTON F. (contact)

PROGRAM_OFFICER_NAME: SHAPIRO, STUART Z

PROJECT_TERMS: Acceleration;Achievement;Acute;Antibodies;Antigens;Autoimmunity;B-Lymphocytes;Binding Sites;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Lineage;Cells;Clinical Trials;design;Development;DNA;efficacy trial;Elements;Evolution;expectation;Fc Receptor;Feedback;Funding;Generations;Genes;Goals;Good Manufacturing Process;Grant;Helper-Inducer T-Lymphocyte;HIV;HIV Antibodies;HIV vaccine;HIV Vaccine Trials Network;HIV-1;HIV-1 vaccine;Human;Immune;Immune response;Immune Tolerance;Immunization;immunogenicity;Immunologics;Immunology;improved;Infection;Knock-in Mouse;Leadership;Macaca;Macaca mulatta;man;manufacture;Mediating;mosaic;multidisciplinary;National Institute of Allergy and Infectious Disease;Nature;neutralizing antibody;novel;operation;Phase;phase I trial;Polysaccharides;preclinical evaluation;prevent;product development;Production;programs;Regimen;Regulatory T-Lymphocyte;Reproducibility;research clinical testing;Research Project Grants;Research Support;response;Route;Sampling;Science;Specificity;Structure;Structure of germinal center of lymph node;T-Lymphocyte;Technology;Testing;Time;tool;translational pipeline;transmission process;vaccine candidate;Vaccine Design;vaccine development;vaccine efficacy;vaccine trial;Vaccines;Virus;Work

PROJECT_TITLE: Induction of protective antibodies for HIV vaccine development


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Human Genome;Immunization;Immunotherapy;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Tuberculosis remains a leading infectious cause of death worldwide, partly due to the lack of an effective vaccine to prevent disease and the lengthy antibiotic treatment courses needed to cure it. The work proposed here is expected to address these obstacles by generating new fundamental information about the population of CD4 T cells that become activated at the site of Mycobacterium tuberculosis infection and by testing the potential of a new immunotherapeutic strategy that harnesses their protective benefit.

PI_NAMEs: BOLD, TYLER DALLAS (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: adaptive immunity;Address;Adoptive Transfer;Agonist;Antibiotic Therapy;Antibodies;Antigens;Blood Vessels;Cause of Death;CD4 Positive T Lymphocytes;Cell Communication;Cell Count;Cell Physiology;Cell Separation;Cell Survival;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;Chronic;chronic infection;Clonal Expansion;Data;Development;Differentiation Antigens;Disease;effector T cell;Failure;fighting;Fluorescence;Genetic Transcription;Immunity;Immunodominant Epitopes;Immunologic Receptors;Immunotherapeutic agent;Immunotherapy;improved;in vivo;Infection;innovation;Knowledge;Lung;Mediating;Mediator;Membrane Proteins;Monoclonal Antibodies;mortality;mouse model;Mus;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;novel;novel marker;novel strategies;novel therapeutic intervention;OX40;Persons;Phenotype;Population;Positioning Attribute;prevent;programs;protein expression;pulmonary function;receptor;Regulatory T-Lymphocyte;Reporter;Resolution;Shapes;Signal Transduction;single-cell RNA sequencing;Site;Specificity;Structure of parenchyma of lung;T cell receptor repertoire sequencing;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;therapeutic target;Time;Tissues;Toxic effect;trafficking;Tuberculosis;tuberculosis immunity;tuberculosis treatment;Tuberculosis Vaccines;Vaccines;Work

PROJECT_TITLE: Harnessing activated CD4 T cells to define new mechanisms of protection in tuberculosis

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_DEPT: SURGERY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PUBLIC HEALTH RELEVANCE During the development of the nervous system, cell groups move extensively to form layers and clusters. Using a group of neuronal progenitor cells in zebrafish, we asking how cell groups generate force and pull themselves forward. This will offer a basis to address medical problems such as neurological disorders.

PI_NAMEs: KNAUT, HOLGER  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Actins;Address;Animals;Back;Basement membrane;Biological Models;Biomechanics;cell motility;Cell Shape;Cells;chemokine;Computer-Assisted Image Analysis;conditional mutant;Cultured Cells;Cytoskeleton;Defect;Development;Disease;Embryo;experimental study;F-Actin;Feedback;Fibroblast Growth Factor;Focal Adhesions;Friction;Future;Generations;Genetic;high resolution imaging;Homeostasis;Human;Human Development;human disease;Image;Impairment;In Vitro;in vivo;Integrins;lateral line;Mediating;Medical;migration;Modeling;Molecular;Motility;Motor;Movement;Muscle;mutant;Myosin Type II;nerve stem cell;Nervous System;nervous system development;Nervous System Disorder;novel;Optics;pathogen;Pattern;Periodicity;Physiologic pulse;Primordium;Process;Protein Kinase;Proteins;public health relevance;response;rho;Role;Shapes;Signal Pathway;Signal Transduction;Skin;System;Talin;Testing;Tissues;Traction;transmission process;wound healing;Zebrafish

PROJECT_TITLE: Biomechanics of Tissue Motility

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Pregnancy;Prevention;Rural Health;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Advancements in prenatal genetic screening have significantly improved the identification of chromosomal abnormalities and heritable conditions during pregnancy, yet current standards for patient education in this domain are largely ineffective. The most effective approach to education about prenatal screening, is one-on- one genetic counseling, but due to the limited number of counselors this is not feasible, especially in rural and frontier areas. We will address this national problem using a novel education game that can more effectively address this gap in healthcare decision-making.

PI_NAMEs: ROTHWELL, ERIN  (contact)

PROGRAM_OFFICER_NAME: LOCKHART, NICOLE C

PROJECT_TERMS: Address;Age;American;American College of Obstetricians and Gynecologists;Appointment;Area;Birth;boys;care providers;Chromosome abnormality;Clinic;Clinic Visits;Clinical;compare effectiveness;Complex;Conflict (Psychology);Couples;Decision Making;design;diabetes management;Discipline of obstetrics;Disparity;Education;Educational Background;effectiveness evaluation;First Pregnancy Trimester;frontier;Genetic;Genetic Counseling;Genetic Risk;Genetic Screening;group intervention;health literacy;Healthcare;Heritability;high risk;Hour;improved;Individual;innovation;Intervention;Interview;Knowledge;Linguistics;low health literacy;Measures;Medical;Methods;novel;Obesity;Outcome;Pamphlets;Participant;Patient Education;Patients;Perception;Persons;Pharmaceutical Preparations;Play;Population;preference;Pregnancy;pregnant;Pregnant Women;prenatal;Prenatal care;prenatal testing;Professional counselor;Provider;Randomized;Recommendation;recruit;Research;Risk;risk perception;Rural;rural area;Rural Population;Sampling;satisfaction;screening;shared decision making;Site;Surveys;Technology;telehealth;Testing;theories;Thinness;Time;tool;treatment as usual;Underrepresented Populations;uptake;urban area;Video Games;Woman;Writing

PROJECT_TITLE: Comparing Game Facilitated Interactivity to Genetic Counseling for Prenatal Screening Education


ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: The Medical Scientist Training Program (MSTP) at the Icahn School of Medicine at Mount Sinai provides a supportive, inclusive, and rigorous dual-degree training environment to prepare physician-scientists to address critical public health challenges. By fostering expertise in biomedical research, translational medicine, and healthcare innovation and promoting collaborative problem-solving and social advocacy skills, the program equips trainees to advance equitable healthcare and improve health outcomes for diverse populations. This integrated approach ensures our graduates are well-prepared to lead transformative efforts in public health and medicine.

PI_NAMEs: SWARTZ, TALIA H (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: Mount Sinai Medical Scientist Training Program


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project narrative Medications for opioid use disorder save lives. However, access to these evidence-based treatments has been uneven across racial and ethnic groups. We examine the role of place, providers, plans and policy in the equitable use of medications for opioid use disorder among Medicaid enrollees using a network of university partnerships with Medicaid agencies in eleven states.

PI_NAMEs: DONOHUE, JULIE MARIE (contact)

PROGRAM_OFFICER_NAME: WILEY, TISHA R  A

PROJECT_TERMS: Accounting;Address;Adopted;Affect;Automobile Driving;barrier to care;behavioral health;Benchmarking;Black Populations;Black race;Buprenorphine;Characteristics;Contracts;COVID-19 pandemic;Criminal Justice;Data;Death Rate;development policy;differences in access;Disparity;Drug Prescriptions;Equity;ethnic difference;ethnic disparity;Ethnic equity;ethnic minority population;Ethnic Origin;Ethnic Population;Evidence based treatment;financial incentive;Formulation;Funding;Gender;Geographic Locations;Geography;Goals;Healthcare;Hispanic Populations;Housing;Improve Access;improved;Incentives;Individual;Inequity;Infrastructure;Investments;Knowledge;Learning;Licensing;Linguistics;Managed Care;Managed Care Programs;Marketing;Measurement;Measures;Medicaid;medical specialties;medication for opioid use disorder;Methadone;Minority;mortality;multilevel analysis;Naltrexone;National Institute of Drug Abuse;opioid epidemic;opioid overdose;opioid treatment program;opioid use disorder;Outcome;Outcome Study;overdose death;overdose prevention;Ownership;Patients;payment;Performance;Persons;Policies;Policy Developments;Policy Maker;Positioning Attribute;prevention service;programs;Provider;provider networks;Quality of Care;Race;racial difference;racial disparity;Racial Equity;racial minority population;racial population;Research;Research Personnel;residential segregation;Role;Services;Single-Payer System;Social Work;Source;Structural Racism;System;Time;Travel;Universities;Variant

PROJECT_TITLE: Improving racial equity in opioid use disorder treatment in Medicaid

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: PHYSIOLOGY

PHR: Project Narrative Acute central nervous system (CNS) injuries such as spinal cord injury, traumatic brain injury, and stroke share many common cellular and molecular mechanisms of damage and repair. These mechanisms often differ substantially from other genetic, developmental, or degenerative brain diseases, necessitating specialized education and research training for those who pursue careers in CNS injury research with the goal of lessening the health-related burden of CNS injury on survivors. The Neurobiology of CNS Injury and Repair T32 Program is designed to provide outstanding, comprehensive educational and research-intensive training to predoctoral students and fully prepare them for their transition to independent careers.

PI_NAMEs: ALILAIN, WARREN JOSEPH;GENSEL, JOHN C;SAATMAN, KATHRYN E (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: central nervous system injury;injury and repair;Neurobiology

PROJECT_TITLE: Neurobiology of CNS Injury and Repair


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Project Narrative:  The body’s epithelial barriers are routinely subjected to inflammatory stressors, necessitating robust regenerative potential to sustain barrier integrity. Following recurrent exposures to inflammatory stressors, tissues and their stem cells become increasingly susceptible to cancer formation. The proposed research will evaluate the long term effects that inflammation has on barrier tissues and how these effects lead to epigenetic rewiring in stem cell populations that results in cancer susceptibility and tumor formation.

PI_NAMEs: COWLEY, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Acceleration;activating transcription factor 3;Acute;Address;Affect;anti-cancer research;Award;Binding;biological adaptation to stress;Cancer Biology;Cancer Model;Carcinoma;Cell Physiology;Cells;Chromatin;chromatin remodeling;Chronic Disease;Classification;Colitis;Colitis associated colorectal cancer;Colon;Colorectal Cancer;Complex;Coupled;cytokine;Development;disease model;Disease Progression;Disseminated Malignant Neoplasm;effective therapy;Enhancers;epigenetic memory;Epigenetic Process;epigenome;epigenomics;epithelial stem cell;Epithelium;Event;experience;Exposure to;Family;Genes;Genetic Diseases;Genetic Screening;Genomics;Goals;Head;histone modification;Homeostasis;Human;human disease;Immunology;in vivo;Inflammation;Inflammatory;inflammatory milieu;Inflammatory Response;insight;Institution;jun Oncogene;Lead;Life;Long-Term Effects;Maintenance;Malignant Neoplasms;MAP Kinase Gene;member;Memory;Modeling;Molecular;Molecular Biology;mouse genetics;Mus;Mutation;Natural regeneration;novel;novel strategies;Oncogenic;Organoids;Papilloma;Pathogenesis;Pathway interactions;Patients;Phase;Physiological;Play;Postdoctoral Fellow;Predisposition;premature;prevent;professor;progenitor;recruit;Recurrence;regeneration potential;Regenerative capacity;Research;Resolution;restoration;Risk;Risk Factors;Role;Shapes;Signal Pathway;Skin;Skin Carcinogenesis;Specialized Epithelial Cell;Squamous cell carcinoma;STAT3 gene;stem;stem cell biology;stem cell population;stem cells;Stimulus;Stress;stressor;Students;System;Technical Expertise;Techniques;tissue stem cells;Tissues;Training;transcription factor;Transcription Factor AP-1;transcriptomics;Transforming Growth Factor beta;tumor;Tumor Burden;tumorigenesis;Work;wound healing

PROJECT_TITLE: Dissecting mechanisms of inflammation driven cancer susceptibility in epithelial barrier tissues


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease

ORG_CITY: IOWA CITY

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative  The proposed continuation of our institutional oral health research training program is designed to provide  training opportunities at the PhD and post-doctoral levels for both dentist and non-dentist scientists, including  training in translational and clinical research, research rigor and reproducibility, and the responsible conduct of  research. This program is designed to allow trainees to develop the complex skills necessary to undertake  independent and collaborative research, and thus to become oral health research scholars capable of meeting  future opportunities and challenges in dental education and oral health research.

PI_NAMEs: LEVY, STEVEN M. (contact)

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: Academia;Address;Advisory Committees;Area;Behavioral Sciences;Big Data;Biocompatible Materials;Biomedical Engineering;Biometry;career;Clinical;clinical investigation;cohort;college;craniofacial;Critiques;Dental;Dental caries;Dentistry;Dentists;Discipline;Doctor of Philosophy;Education;Educational process of instructing;Educational workshop;Environment;Epidemiology;experience;Faculty;faculty mentor;Fellowship;Funding;Genetic;Grant;Health Policy;Health Sciences;Immunology;improved;Inflammation;Institution;Interdisciplinary Study;International;Iowa;K-Series Research Career Programs;Leadership;leadership development;malignant mouth neoplasm;Mentors;Microbiology;microbiome;Odontogenesis;Oral;oral biology;Oral health;Outcome;Postdoctoral Fellow;pre-doctoral;Productivity;programs;Public Health;recruit;Research;research facility;Research Personnel;Research Training;Science;Series;skills;stem cells;success;Tissue Engineering;Training;Training Programs;Translational Research;translational scientist;Universities;Update;Writing

PROJECT_TITLE: University of Iowa Institutional Training Program in Oral Health Research


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: HANOVER

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: NARRATIVE Given their use in evaluation of both pathology of and interventions against diverse respiratory pathogens, there is a critical need to understand the suitability and/or shortfalls of ferret and hamster animal models in recapitulating the antibody effector functions that can affect human clinical outcomes. The goal of this project is to define antibody and antibody receptor biology in these species, which may be essential for improving our ability to effectively translate results of active and passive immunization studies performed in these animal models to the clinic.

PI_NAMEs: ACKERMAN, MARGARET E (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: 2019-nCoV;Achievement;Active Immunization;Address;Affect;Animal Model;animal model development;Animals;Antibodies;Antibody Response;Antibody titer measurement;antibody-dependent cell cytotoxicity;Antigen-Antibody Complex;Antigens;Architecture;Basic Science;Biocompatible Materials;Biological;Biology;biophysical analysis;Biophysics;Cell Line;Cells;Cellular Assay;Characteristics;Clinic;Clinical;Clinical Trials;Data;Development;Disease;Disease Progression;Effector Cell;emerging virus;Evaluation;experience;Fc domain;Fc Receptor;Ferrets;Genetic;Genetic Variation;Goals;Hamsters;Health;Human;Immune;immune activation;Immune response;Immunity;immunogenicity;Immunoglobulin G;improved;In Vitro;in vitro Assay;in vivo;Infection;Inflammation;Influenza;innovation;insight;Intervention;Knowledge;Macaca mulatta;Measures;Mediating;Mesocricetus auratus;Modeling;monocyte;Mus;Mustela putorius furo;Natural Killer Cells;nonhuman primate;novel;Outcome;pandemic disease;Passive Immunization;pathogen;Pathologic;Pathology;Pattern;Pattern recognition receptor;Phagocytosis;pre-clinical;Pre-Clinical Model;Preclinical Testing;Prevention strategy;Property;receptor;receptor binding;Research;research and development;respiratory pathogen;Respiratory System;Respiratory Tract Infections;response;Rewards;Risk;Role;Safety;Seasons;stable cell line;Testing;Therapeutic;Therapeutic antibodies;tool;Translating;translational study;Translations;transmission process;treatment strategy;vaccine-induced antibodies;Vaccines;Viral;Viral Antibodies;Viral Physiology;viral transmission;Virus;Virus Diseases;Work

PROJECT_TITLE: IgG and FcR Characterization in Small Animal Models of RespiratoryDisease

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Colorectal Cancer;Digestive Diseases;Immunotherapy;Inflammatory Bowel Disease;Microbiome

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PUBLIC HEALTH RELEVANCE Effective treatments are needed for colon cancer. Inflammatory microenvironment in colon cancer is critical for the growth and progression of colon cancer. This grant will characterize if targeting HIF2α alters tumor growth via decreasing the immunosuppressive tumor microenvironment.

PI_NAMEs: SHAH, YATRIK M (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Adjuvant;Area;Automobile Driving;Blood Vessels;Cancer Etiology;cancer initiation;cancer risk;Cells;Cessation of life;Chronic;Clear cell renal cell carcinoma;Clinical Trials;Colitis;Colitis associated colorectal cancer;colon cancer progression;colon cancer risk;colon carcinogenesis;Colon Carcinoma;Colonic Neoplasms;Data;Dinoprostone;Disease;Drug Targeting;effective therapy;efficacy evaluation;Environment;Epithelial Cells;Epithelium;Fibroblasts;Genetic Predisposition to Disease;Grant;Growth;gut microbiota;healing;Hydrophobic Surfaces;Hypoxia;Hypoxia Inducible Factor;Immune;immune checkpoint blockers;Immunosuppression;in vivo;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;inhibitor;Injury;intestinal injury;Intestines;Ligands;Mediating;Metabolic;Metabolic Pathway;microbial;microbiota;microbiota metabolites;Modeling;mouse model;Mus;Natural regeneration;neoplastic cell;Neoplastic Cell Transformation;neutrophil;Neutrophil Infiltration;new therapeutic target;novel;novel therapeutics;Pathway interactions;Physiological;Pre-Clinical Model;Production;public health relevance;regeneration following injury;Regulation;Renal Carcinoma;Reporter;Research;Research Proposals;Resolution;response to injury;Role;Solid Neoplasm;Structure;Testing;therapeutic target;tissue repair;Tissues;transcription factor;Treatment Efficacy;tumor;tumor growth;tumor microenvironment;tumor progression;tumor-immune system interactions;United States;Work

PROJECT_TITLE: The role of HIF2alpha in colon carcinogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DNPD-A(01)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Various adverse and protective environments may affect child development. The Healthy Brain and Child Development (HBCD) Consortium will follow 7,200 mothers and their children from 27 locations across the US from before birth to 10 years of age to better understand which harmful and protective environments exert the greatest impact on child development. The HBCD Study will inform public policy to improve the health and development of children across the nation.

PI_NAMEs: BOSQUET ENLOW, MICHELLE A;GRANT, PATRICIA ELLEN (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: 10 year old;Address;Adverse event;Affect;Alcohols;Behavioral;Biological;Birth;Brain;Caregivers;caregiving;Child;child bearing;Child Development;cohort;Communities;Conceptions;COVID-19;critical period;Data;Data Collection;Data Coordinating Center;data integrity;Data Set;data standards;design;Development;DNA;early experience;early life exposure;Electroencephalography;Enrollment;Environment;Environmental Exposure;Environmental Hazards;Epigenetic Process;Ethics;Ethnic Origin;Event;experience;Exposure to;Feedback;General Population;Genes;Goals;hazard;Health;Helping to End Addiction Long-term;Human;improved;Infant;Infection;innovation;insight;Life;Link;Location;Magnetic Resonance Imaging;Malnutrition;maltreatment;Marijuana;Maternal Health;maternal stress;Measures;Methods;Modality;Monitor;Mothers;multidimensional data;multimodality;neurodevelopment;neuroimaging;Newborn Infant;novel;Opiate Addiction;Opioid;opioid misuse;Outcome;Participant;Persons;Physiological;Population;postnatal;Pregnancy;pregnant;Pregnant Women;prenatal;prenatal exposure;Process;protective factors;Protocols documentation;psychologic;Psychopathology;Public Health;Public Policy;Race;recruit;remote assessment;Research;Research Design;Research Personnel;Sampling;Second Pregnancy Trimester;Severities;Shapes;Site;socioeconomics;sound;Speed;stem;Stress;Structural Racism;substance use;Time;Time Study;Tobacco;tool;Toxicant exposure;Training;United States;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: 5/24 Healthy Brain and Child Development National Consortium

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-D(51)R]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences

PHR: Project Narrative Neurodevelopmental disorders such as autism spectrum disorders, attention deficit hyperactivity disorder, schizophrenia and intellectual disability are estimated to impact ~ 1 in 6 individuals in the United States. While currently available treatments have only limited impact on short- and long-term outcomes for most NDDs, advances in genetics and neuroscience are changing the landscape of research and opening possibility of bringing mechanism-based therapies to those affected with such disorders. The Translational Postdoctoral Training in Neurodevelopment (TPND) Program at Boston Children's Hospital will train postdoctoral neuroscience investigators (MD, PhD or MD/PhD) to develop and implement new medical and behavioral treatments for a range of neurodevelopmental disorders impacting children and their families.

PI_NAMEs: GLAHN, DAVID C;NELSON, CHARLES ALEXANDER (contact);SAHIN, MUSTAFA

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: neurodevelopment;post-doctoral training

PROJECT_TITLE: Translational Post-doctoral Training in Neurodevelopment


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PI_NAMEs: CANTLEY, LLOYD G;EDELMAN, E. JENNIFER;SHAPIRO, EUGENE DAVID (contact)

PROGRAM_OFFICER_NAME: MERCHANT, CAROL

PROJECT_TERMS: Academia;Address;Applied Research;Area;Arts;Big Data;Bioethics;Bioinformatics;burden of illness;career;career development;Clinical;Clinical Research;Clinical Trials;community based participatory research;Competence;Complex;curriculum enhancement;Development;Discipline;Discipline of Nursing;diversity and inclusion;Doctor of Medicine;Education;Educational Curriculum;Engineering;experience;externship;Faculty;Feedback;Funding;Good Clinical Practice;Grant;Health;health disparity;Health Sciences;Healthcare;Healthcare Systems;implementation science;improved;Industry;Institution;Interdisciplinary Study;Laboratory Research;Leadership;Learning;Logic;Machine Learning;Medical Education;medical schools;Mentors;Mentorship;Modeling;multidisciplinary;next generation;Pathway Analysis;peer coaching;Positioning Attribute;Preparation;programs;Public Health;Publications;Qualifying;Research;Research Personnel;Running;Scholars Program;Science;Shapes;Social Network;success;Talents;Training;Translational Research;translational scientist;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: Institutional Career Development Core


NIH_SPENDING_CATS: Genetics;Hematology;Immunotherapy;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: T-cells are a type of white blood cell that are needed to fight infections and can be artificially programmed to destroy cancer cells in patients. The goal of this project is to decipher the gene programs that drive the formation of T-cells and define whether increasing the activity of the gene BCL11B will improve the generation of T-cells from renewable stem cell sources. The potential benefit of the knowledge gained from this project is the development of ways to more efficiently generate off the shelf anti-cancer T-cell immunotherapies from stem cell sources.

PI_NAMEs: CROOKS, GAY M (contact);PAREKH, CHINTAN

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Affect;anti-cancer;Autologous;Binding;cancer cell;candidate identification;Cell Lineage;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;CHD4 gene;chimeric antigen receptor;Chromatin;chromatin remodeling;Data;design;Development;Epigenetic Process;Event;fighting;Generations;Genes;Genetic Engineering;Genetic Transcription;Goals;Hematopoiesis;Hematopoietic stem cells;Heterogeneity;histone modification;Human;human pluripotent stem cell;Immunotherapy;improved;in vitro Model;indexing;Infection;insight;knock-down;Knowledge;Leukocytes;loss of function;Lymphoid;Lymphoid Cell;manufacture;Mature T-Lymphocyte;Mediating;Methods;Molecular;mouse model;Mus;notch protein;NOTCH1 gene;novel;NuRD complex;Organoids;Output;overexpression;Pathway interactions;Patients;Pattern;pluripotent stem cell differentiation;Pluripotent Stem Cells;Population;Process;Production;progenitor;programs;Publishing;recruit;Reporter;Repression;Role;self-renewal;Series;Signal Transduction;single-cell RNA sequencing;Sorting;Source;Specific qualifier value;stem cell population;stem cells;System;T cell differentiation;T cell therapy;T-Cell Development;T-Lymphocyte;Therapeutic;Thymus Gland;transcription factor;Umbilical Cord Blood;Variant

PROJECT_TITLE: The role of BCL11B in T lineage fate during human thymopoiesis and pluripotent stem cell differentiation


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Narrative The ability to study neuronal communication is crucial for understanding neural physiology and pathology to reveal cortico-thalamo-cortical interactions. Neuronal communication cannot be elucidated fully without a technology to image and manipulate individual neurons in multiple layers spanning the cortex and at multiple sites across the brain. While three-photon microscopy has the requisite penetration depth, its modest speed limits its use in multiple site studies, so I propose a multifoci, two- and three-photon microscope and an optogenetic excitation platform to overcome this challenge in behaving mice.

PI_NAMEs: YILDIRIM, MURAT  (contact)

PROJECT_TITLE: Developing next generation multiphoton systems to reveal cortico-thalamic interactions underlying short-term memory in behaving mice


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Prevention;Sexually Transmitted Infections;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE People with sexually transmitted infections (STI) who report hazardous drinking are a priority population for interventions to improve primary and secondary HIV prevention. We will adapt and test a brief alcohol reduction intervention to integrate primary and secondary HIV prevention counseling for people with and at risk of HIV who report hazardous drinking and are receiving STI care. Our study will provide critical guidance to practitioners, program implementers, and policymakers on the efficacy and implementation of alcohol reduction interventions for people receiving STI care in resource-limited settings.

PI_NAMEs: LANCASTER, KATHRYN ELIZABETH;PARCESEPE, ANGELA  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Adherence;Adult;Africa South of the Sahara;AIDS prevention;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;Alcohol dependence;alcohol intervention;alcohol prevention;alcohol use disorder;Alcohols;antiretroviral therapy;arm;Behavior Therapy;Behavioral;Biological Markers;Caring;Clinic;co-infection;Cognitive;Counseling;effectiveness study;effectiveness/implementation trial;Elements;Enrollment;Environment;Evidence based intervention;Failure;flexibility;Goals;hazardous drinking;Heavy Drinking;high risk;high risk population;HIV;HIV Seronegativity;Human immunodeficiency virus test;implementation measures;implementation study;improved;Incidence;Infection;innovation;Intervention;intervention participants;Interview;Malawi;Manuals;men;Methods;Modeling;Motivation;motivational enhancement therapy;Multiple Partners;Newly Diagnosed;Outcome;Participant;Pathway interactions;Persons;phosphatidylethanol;Policy Maker;Population Heterogeneity;Population Intervention;Populations at Risk;pre-exposure prophylaxis;Prevalence;prevention effectiveness;Prevention program;Problem Solving;Professional counselor;programs;Provider;Public Health;Randomized;Randomized, Controlled Trials;reduced alcohol use;Reporting;Research;Research Infrastructure;Resource-limited setting;responders and non-responders;Risk;Sexually Transmitted Diseases;Site;skills;Structure;success;Testing;transmission process;treatment as usual;Treatment Effectiveness;treatment optimization;Treatment outcome;treatment program;trial comparing;Unsafe Sex;uptake;Viral;Virus Shedding;Woman;Work

PROJECT_TITLE: Enhancing HIV prevention and reducing alcohol use among people receiving STI care in Malawi: An HIV status neutral approach

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Neurosciences;Pain Research;Precision Medicine;Prevention

PHR: PROJECT NARRATIVE Abdominal pain in chronic pancreatitis (CP) affects approximately 90% of patients and is the primary driver of morbidity, poor quality of life, and health care utilization. Response to currently available therapies is suboptimal and predicting which individuals will respond to invasive treatment has not been possible to date. The proposed clinical trial will evaluate the predictive capability of Pancreatic Quantitative Sensory Testing (P- QST, a novel assessment of neurosensory phenotyping) for improvement in pain (a health-related outcome) in patients with CP who are undergoing medically-indicated invasive treatment with endoscopic therapy or surgery.

PI_NAMEs: PHILLIPS, ANNA EVANS (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Abdominal Pain;Adopted;Affect;Algorithms;Analgesics;Automobile Driving;Biochemical;Biological Markers;central pain;central sensitization;chemokine;chronic pancreatitis;Clinical;Clinical Trials;cost;Data;demographics;Denmark;dermatome;Development;disability;Disease;Drainage procedure;Duct (organ) structure;Enrollment;Enzyme-Linked Immunosorbent Assay;Etiology;experience;Fibrosis;follow-up;Foundations;Goals;Health;Health Care Costs;health care service utilization;Health Expenditures;high risk;Hyperalgesia;impression;improved;Individual;individual patient;inflammatory marker;Investigative Techniques;Lasso;Linear Regressions;Machine Learning;Measures;Medical;Modeling;Morbidity - disease rate;Multicenter Studies;Nerve;neuroinflammation;Neuronal Plasticity;Neurons;Neuropathy;neurosensory;neurotransmission;Nociception;nociceptive response;Nomograms;novel;Numeric Rating Scale;Obstruction;Operative Surgical Procedures;opioid therapy;opioid use;Outcome;Pain;Pain management;Pain Measurement;pain processing;pain reduction;pain relief;pain score;Pancreas;Pancreatic Diseases;Pancreatic duct;Patient Outcomes Assessments;patient response;patient subsets;patient variability;Patients;Peripheral Nervous System Diseases;Persistent pain;personalized approach;personalized predictions;Persons;Phenotype;post intervention;predicting response;Prediction of Response to Therapy;predictive modeling;Prevalence;primary outcome;Probability;Procedures;productivity loss;Proteins;Protocols documentation;psychiatric comorbidity;Quality of life;Reporting;response;Risk;Risk Reduction;Role;Sampling;secondary outcome;Sensory;Serum;Severities;side effect;Spinal;Standardization;Stimulus;success;symptom management;Techniques;Testing;tool;Treatment outcome;treatment strategy;Universities;Up-Regulation;Urine;Visceral;Wages

PROJECT_TITLE: P-QST Project: Pancreatic Quantitative Sensory Testing (P-QST) to Predict Treatment Response for Pain in Chronic Pancreatitis

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Aging;Autoimmune Disease;Behavioral and Social Science;Biomedical Imaging;Cardiovascular;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Digestive Diseases;Heart Disease;Liver Disease;Lung;Neurosciences;Nutrition;Obesity;Physical Activity;Prevention

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Project Narrative  Type 1 diabetes mellitus (T1DM) affects over 1,800,000 Americans and Canadians who are at risk of developing microvascular (eye, nerve, and kidney) and cardiovascular complications that are a major cause of morbidity, mortality, and health care cost. Based on advances in diabetes care, largely resulting from the findings of the DCCT, patients with T1DM now live longer lives and are experiencing the increasing body weight that is prevalent in the non-diabetic and type 2 diabetes populations. EDIC will turn its attention to understanding the effects of very long T1DM duration in our aging and increasingly overweight and obese population, which reflects T1DM in the U.S. and Canada, and to exploring potentially modifiable risk factors for advanced microvascular complications, cardiac disease including the early stages of heart failure, fatty liver disease and sleep apnea, and cognitive and physical dysfunction.

PI_NAMEs: BEBU, IONUT ;BRAFFETT, BARBARA HALINA;GUBITOSI-KLUG, ROSE A (contact)

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: Activities of Daily Living;Address;adjudication;Adopted;Advanced Development;Adverse effects;adverse outcome;Affect;Age;Aging;American;Amputation;Anatomy;Angiography;arterial stiffness;Attention;Autonomic Dysfunction;Biological Markers;Blindness;Blood Vessels;Canada;Cardiac;Cardiopulmonary;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Caring;Clinical;Clinical Treatment;Clinical Trials;Cognitive;cognitive function;cohort;Cohort Studies;community based care;Community Trial;comorbidity;Complications of Diabetes Mellitus;conventional therapy;cost;Development;diabetes control;diabetes management;Diabetes Mellitus;Disease;Disease Outcome;Echocardiography;economic impact;economic outcome;effective intervention;Epidemiology;Epigenetic Process;Esthesia;Event;Exercise;exercise intolerance;Exercise Test;experience;Exposure to;Eye;fatty liver disease;Fibrosis;fitness;follow-up;Follow-Up Studies;frailty;Functional disorder;Functional Imaging;Funding;Generations;Genetic;Glucose;Glycosylated hemoglobin A;Goals;health assessment;Health Care Costs;health economics;Heart Diseases;Heart failure;Heterogeneity;high risk;Hyperglycemia;Impaired cognition;Impairment;improved;Incidence;indexing;Individual;Inflammation;innovation;Insulin-Dependent Diabetes Mellitus;Intervention;Kidney;Kidney Diseases;Kidney Failure;Kinetics;Knowledge;Lead;lens;life span;Liver;Liver diseases;liver stiffness;Longevity;Longitudinal cohort study;Lung;macrovascular disease;Measurement;Measures;Mediation;Memory;Metabolic;Methods;Microvascular Dysfunction;modifiable risk;Morbidity - disease rate;mortality;Myocardial;Nerve;Neurocognition;Neuropathy;non-alcoholic fatty liver disease;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;North America;novel;obese person;Obesity;Observational Study;Obstructive Sleep Apnea;Optical Coherence Tomography;Organ;Outcome;Overweight;Oxygen;painful neuropathy;Participant;Pathway interactions;Patients;Pattern;Performance;Phenotype;Physical Function;Population;Prevalence;public health priorities;Quality of life;Questionnaires;Randomized;Recording of previous events;Reporting;Resistance;response;Retina;Retinal Diseases;Risk;Risk Factors;Self Management;Severity of illness;skeletal;sleep abnormalities;Sleep Apnea Syndromes;standard of care;Standardization;Steatohepatitis;Stress;structural imaging;study population;Subgroup;Symptoms;Time;tonometry;Ulcer;uptake;Vital Status;Weight Gain

PROJECT_TITLE: Epidemiology of Diabetes Interventions and Complications (EDIC) Study


NIH_SPENDING_CATS: Behavioral and Social Science;Dissemination and Implementation Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Opioid Misuse and Addiction;Opioids;Prevention;Substance Misuse

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: Project Narrative The United States is reeling from an unrelenting crisis of opioid overdose deaths, with over 100,000 drug overdose deaths reported in the 12-month period ending in April 2021, representing nearly 30% year-on-year increase. A Harm Reduction Network will be established to enhance understanding of the effectiveness and associated implementation facilitators and barriers of harm reduction strategies to address the ongoing opioid crisis. As the Coordinating Center, RTI will facilitate scientific, administrative, and logistical support, HEAL data harmonization and sharing, stakeholder engagement, and timely dissemination.

PI_NAMEs: CANCE, JESSICA DUNCAN (contact)

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: Acceleration;Address;Area;Award;clinical practice;Clinical Research;Clinical Trials;Collaborations;Common Data Element;Communication;Communities;community engagement;Consultations;data harmonization;data infrastructure;data sharing;Dedications;design;Development;dissemination strategy;diverse data;Drug usage;Effectiveness;Environment;Epidemiology;evidence base;experience;Feedback;fentanyl test;Fostering;Harm Reduction;harm reduction programs;Helping to End Addiction Long-term;high risk;implementation barriers;implementation evaluation;implementation facilitators;implementation outcomes;implementation science;implementation strategy;improved;Individual;Infrastructure;infrastructure development;innovation;Leadership;Lived experience;Measures;Methodology;Modeling;Monitor;Morbidity - disease rate;mortality;naloxone dispensing;Needle-Exchange Programs;operation;Opioid;opioid epidemic;opioid mortality;Outcome;Overdose;overdose death;overdose education;Pharmaceutical Preparations;Policies;Population;Population Heterogeneity;Principal Investigator;Process;programs;Protocols documentation;Public Health;Recommendation;Reporting;Research;Research Design;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;research study;Research Support;Resources;response;Role;Running;service providers;Site;Source;Statistical Data Interpretation;Structure;substance use;Substance Use Disorder;success;support network;systematic review;test strip;theories;tool;Translating;Translational Research;Translations;United States;United States National Institutes of Health;user centered design;Voice;web portal

PROJECT_TITLE: RTI HEAL Harm Reduction Network Coordination Center


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Emphysema;Genetics;Lung;Precision Medicine;Rare Diseases

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Research has contributed to an understanding of the pathogenesis of Alpha-1 antitrypsin deficiency (AATD), the first identified heritable cause of chronic obstructive pulmonary disease (COPD), however, much remains to be defined regarding its natural history, treatment strategies and clinical course. The most fundamental barrier to effective therapeutic approaches to AATD is a lack of suitable biomarkers that are specific for disease progression or correlate with a specific disease phenotype. Therefore, the present initiative will form a prospective cohort of individuals with AATD (Alpha-1 Clinical Cohort, A1CC) and identify individuals with AATD related COPD to enter into a biomarker study through the Alpha-1 Biomarker Research Consortium (A1BReC), with the goal of identifying new biomarkers and elucidating genotype/phenotype relationships in the disease.

PI_NAMEs: D'ARMIENTO, JEANINE M (contact);STRANGE, CHARLTON B

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Address;airway remodeling;alpha 1-Antitrypsin;alpha 1-Antitrypsin Deficiency;Biological;Biological Markers;biomarker identification;biomedical informatics;Categories;Characteristics;Chest imaging;Chronic Obstructive Pulmonary Disease;Clinical;Clinical Data;clinical heterogeneity;Clinical Research;clinical research site;Clinical Trials;clinically relevant;cohort;Collaborations;Contracts;Data;data access;data sharing;Databases;Dimensions;Disease;disease heterogeneity;Disease Outcome;disease phenotype;Disease Progression;DNA;Enhancers;Enrollment;Equilibrium;exome sequencing;Foundations;Fractals;Funding;Generations;Genes;Genetic;Genetic Polymorphism;Genotype;Goals;Heritability;imaging biomarker;imaging modality;immune function;improved;In Vitro;Individual;induced pluripotent stem cell;Inflammatory Response;Informed Consent;Injury;Institution;Institutional Review Boards;Knowledge;Leukocyte Elastase;Link;Liver diseases;Longitudinal cohort;Lung;Lung Diseases;Macrophage;Manuals;Matrix Metalloproteinases;Measurement;Measures;Mechanics;multidisciplinary;Mutation;Natural History;novel;novel marker;Participant;participant retention;Pathogenesis;Patient Care;Patients;Peptide Hydrolases;Phase;Phenotype;Plasma;Population;Preparation;Procedures;Prognosis;promoter;prospective;Prospective cohort;Protease Inhibitor;Protocols documentation;Pulmonary Emphysema;pulmonary function decline;recruit;Registries;Research;Research Infrastructure;Research Personnel;response;Role;Secure;Series;Serine Proteinase Inhibitors;Serum;Severities;specific biomarkers;Sputum;Testing;therapeutically effective;Time;treatment strategy;user-friendly;Validation

PROJECT_TITLE: Alpha-1 Antitrypsin Disease Cohort: Longitudinal Biomarker  Study of Disease


NIH_SPENDING_CATS: Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: HOUSTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Post-transcriptional mechanisms have the potential to influence complex changes in gene expression, yet their role in mammalian cell fate transitions remains incompletely understood. The research outlined in this proposal will elucidate the cellular, molecular, and functional role of RNA sequestration in mammalian embryogenesis and adult hematopoietic homeostasis. We expect that results from these studies will yield fundamental insights into the general principles that control cell identity and enable the development of novel anti-cancer and regenerative medicine therapies.

PI_NAMEs: DI STEFANO, BRUNO  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Adult;anti-cancer;Basic Science;Cell Fate Control;Cells;Complex;Cytoplasm;Development;Ectoderm;Embryo;embryo cell;Embryonic Development;embryonic stem cell;Endoderm;Gene Expression;Goals;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Homeostasis;innovation;insight;Malignant Neoplasms;Mammalian Cell;Maps;Mesoderm;Molecular;novel;novel therapeutic intervention;Physical condensation;Play;Pluripotent Stem Cells;Post-Transcriptional Regulation;posttranscriptional;Process;progenitor;programs;Protein Isoforms;regenerative approach;Regenerative Medicine;Regulation;Regulator Genes;Research;RNA;RNA methylation;RNA Processing;Role;Specific qualifier value;Technology;Tissues;tool;Transcript;translational medicine;translatome;Work

PROJECT_TITLE: DEFINING THE ROLE OF RNA SEQUESTRATION IN MAMMALIAN CELL FATE

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]