ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Patient Safety

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Narrative The primary aim of this 90-day randomized trial in older adults with Alzheimer's Disease and mild dementia will determine whether nicotinamide mononucleotide (NMN), a NAD+ precursor, crosses the blood-brain barrier, and engages the hypothesized target mechanism. This request for supplemental funds was necessitated by the delay in trial's completion due to multiple unanticipated factors that are described in the Research Strategies section. This application for administrative supplement requests funds to support the addition of a second clinical trial site to expedite participant recruitment, enable the completion of the trial and accomplishment of the proposed aims of the project.

PI_NAMEs: BHASIN, SHALENDER  (contact);MARSHALL, GAD ASHER

PROGRAM_OFFICER_NAME: CLARKE, AKANNI YAO

PROJECT_TERMS: Administrative Supplement;adverse event monitoring;aging biomarker;aging mechanism;Alzheimer's Disease;Amyloid beta-42;Amyloid deposition;Area;Biological Assay;Biological Markers;Blood;blood-brain barrier crossing;blood-brain barrier penetration;Boston;Brain;Cerebrospinal Fluid;Chemistry;circulating biomarkers;Clinical Trials;Coagulation Process;Cognition;Cognitive;Collection;Confidence Intervals;cost;Cost Savings;COVID-19 pandemic;Data;Dementia;Dose;efficacy trial;Electrocardiogram;Enrollment;Exclusion;F2-Isoprostanes;Funding;Geroscience;Glial Fibrillary Acidic Protein;Glycosylated hemoglobin A;Head;Health care facility;Human;IGF1 gene;IL6 gene;improved;Institutional Review Boards;instrumental activity of daily living;Intervention;Israel;Laboratories;Leadership;Light;Magnetic Resonance Spectroscopy;Manuscripts;Measures;Mechanics;Medical center;metropolitan;Nerve Degeneration;neurofilament;neurogranin;neuroinflammation;Neurologist;neuropsychiatric symptom;Niacinamide;Nicotinamide Mononucleotide;older adult;Oral;Oral Administration;Outcome;parent project;Participant;Pathway interactions;Patient Recruitments;payment;Peripheral Blood Mononuclear Cell;Placebos;Preparation;Principal Investigator;Procedures;programs;Protocols documentation;Randomized;randomized trial;Recommendation;Regulation;Reporting;Request for Applications;Research;Research Personnel;research study;Role;Safety;Savings;Secure;Serious Adverse Event;Serum;SIRT1 gene;Sirtuins;Site;Spinal Puncture;Structure;synaptic function;tau Proteins;tau-1;Testing;Time;United States Food and Drug Administration;United States National Institutes of Health;urinary

PROJECT_TITLE: A Proof of Concept Trial of a Sirtuin-NAD+ Activator in Alzheimer's Disease


ADMINISTERING_IC: MH

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Pediatric;Serious Mental Illness;Women's Health Research

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: LAC Narrative The goals of the proposed SCORE are to identify stress-immune pathway abnormalities beginning in fetal development that impact key stress-related neural circuits resulting in shared consequences for sex differences in lifelong depression and autonomic and other physiologic dysregulation. Our SCORE proposes a set of synergistic basic and clinical studies in tandem with cores to share technological expertise and enhance the training of the next generation. The LAC will oversee responsibility for: maintaining connections between sites and studies, setting up meetings and conference calls to review study progress, budget administration, organizing symposia and conferences, publicizing opportunities for trainees, supporting new initiatives, and implementing dissemination of the knowledge gained to the scientific and medical communities, policy makers, and the public.

PI_NAMEs: GOLDSTEIN, JILL M (contact)

PROGRAM_OFFICER_NAME: EVANS, JOVIER D

PROJECT_TERMS: Animal Model;Animals;Biological Models;brain circuitry;Budgets;Cardiovascular Diseases;career;Centers of Research Excellence;Clinical;Clinical Investigator;Clinical Medicine;Clinical Research;Collaborations;Communities;Consultations;Country;disability;Discipline;Disease;disorder risk;Early Intervention;Educational workshop;Electronic Mail;Endocrinology;Evaluation;Expenditure;Fetal Development;Functional disorder;Funding;Future;Genetic;Goals;Heart Diseases;high risk;Hormones;Human;Immune;Immune response;Immunology;Infrastructure;Institution;Interdisciplinary Study;Knowledge;late life;Leadership;Life;Locales;Major Depressive Disorder;Medical;meetings;Mental Depression;Metabolic Diseases;Methodology;Methods;middle age;Mission;Modeling;Monitor;Moods;mortality risk;neural circuit;Neurology;Neurosciences;neurovascular;next generation;novel;novel strategies;Pathway interactions;Peripheral;Physiological;Policy Maker;Population;prenatal;prenatal stress;Psychiatry;Public Health;Publications;Radiology Specialty;Recurrence;Reporting;Resources;Risk;Schedule;Scientist;Series;sex;sex as a biological variable;Sex Differences;Site;Specialized Center;specific biomarkers;Stress;symposium;synergism;Technology;Telephone;Therapeutic;Thinking;Time;tool;Training;Translating;Translational Research;translational study;United States National Institutes of Health;web site;Woman;Women's mortality;Work

PROJECT_TITLE: Leadership Administrative Core


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: STONY BROOK

ORG_DEPT: DERMATOLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: NARRATIVE The interactions between keratinocytes and dermal papilla cells are essential for the formation of the hair follicles and the production of the hair shaft but the precise mechanisms are poorly defined. Here, we propose to investigate the role of the proteoglycans produced by the dermal papilla cells on the dermal papilla aggregate formation and hair follicle keratinocyte proliferation. Knowledge gained from this study will shed light on basic biological processes underlying cell-cell interaction and provide novel insight in hair loss.

PI_NAMEs: CHEN, JIANG  (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Adhesions;Basement membrane;behavior influence;Binding;Biological;Biological Markers;Biological Process;Biology;Cell Aggregation;Cell Communication;cell motility;cell type;Cells;Cleavage Under Targets and Release Using Nuclease;Collection;Contracts;Cre driver;Data;Deposition;Dermal;Embryonic Development;Engineering;Erinaceidae;experimental study;extracellular;Extracellular Matrix;Fibrosis;gain of function;Genes;Genetic Transcription;Goals;Growth;Hair;Hair bulb structure;Hair follicle structure;Hair shaft structure;Impairment;in vivo;in vivo Model;inducible Cre;inhibitor;insight;Integrin Signaling Pathway;Integrins;Investigation;keratinocyte;Knowledge;Ligand Binding;Ligands;Link;Literature;live cell imaging;loss of function;Maintenance;Maps;Mediating;Mediator;Mesenchymal;migration;Molecular;molecular modeling;Morphogenesis;mouse model;Names;Natural regeneration;novel;Outcome;overexpression;Paracrine Communication;Play;postnatal;Production;Proliferating;Proteins;Proteoglycan;receptor;Regulation;Role;scaffold;Signal Pathway;Signal Transduction;Skin;smoothened signaling pathway;superresolution imaging;Surface;Tissues;tongue papilla;tool;Transcriptional Regulation;transcriptome sequencing;tumor microenvironment;versican;Western Blotting

PROJECT_TITLE: Instructive roles of mesenchymal proteoglycans in hair follicle morphogenesis and maintenance

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: CA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: RICE UNIVERSITY

ORG_STATE: TX

PHR: PROJECT NARRATIVE This project aims to understand the complex biological system of mantle cell lymphoma (MCL) and its contribution to clinical outcomes including therapeutic response and survival. We will conduct an innovative multi-omic pooled analysis of MCL patients that have undergone molecular studies at the University of Texas MD Anderson Cancer Center (MDACC). We intend to use statistical techniques, computational tools and software to identify clinically useful variables and prognostic features to personalize treatments for MCL.

PI_NAMEs: HILL, HOLLY ANN (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Affect;Age;Alcohol consumption;analytical method;Area;Biological;Biological Assay;Cancer Patient;cancer type;CCND1 gene;CDKN2A gene;Characteristics;chemotherapy;circular RNA;Clinical;clinical investigation;Clinical Research;clinically relevant;complex biological systems;Computer software;computerized tools;Computing Methodologies;Correlative Study;Data;Data Set;Databases;differential expression;Disease;Disease Progression;Disease stratification;DNA;DNA sequencing;Drug Targeting;Environmental Exposure;Epigenetic Process;epigenomics;exome sequencing;feature selection;Frequencies;Functional disorder;Gene Expression;Gene Expression Profile;gene interaction;Genes;genetic analysis;Genetic Heterogeneity;Genetic Transcription;Genome;genome sequencing;Genomic Instability;Genomics;Glean;Hematopoiesis;Holly;imprint;Individual;individual patient;innovation;insight;Investigation;Knowledge;Laboratories;lifestyle factors;Link;liquid biopsy;Malignant Neoplasms;Mantle Cell Lymphoma;Measurement;Meta-Analysis;Methods;Modeling;Molecular;Molecular Abnormality;Morphology;Multiomic Data;multiple omics;Mutate;Mutation;Mutation Analysis;mutational status;next generation sequencing;Non-Hodgkin's Lymphoma;NOTCH1 gene;novel;Other Genetics;Outcome;Output;Pathway Analysis;Pathway interactions;Patients;Pattern;personalized approach;personalized medicine;personalized therapeutic;Pharmaceutical Preparations;Phase;pre-doctoral;Precision Medicine Initiative;Precision medicine trial;Prevalence;Principal Component Analysis;Prognosis;prognostic;Race;Radiation exposure;Relapse;Reporting;Research;Research Project Grants;Resistance;response;Sample Size;Sampling;sex;Single Nucleotide Polymorphism;Smoking;Statistical Models;survival outcome;synergism;targeted treatment;Techniques;The Cancer Genome Atlas;therapy resistant;TP53 gene;transcriptome sequencing;transcriptomics;Translating;treatment response;tumor DNA;tumor microenvironment;University of Texas M D Anderson Cancer Center;Variant;whole genome

PROJECT_TITLE: Precision Approaches to Treat Mantle Cell Lymphoma: Integrating Multi-omics Based Models


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Chronic Pain;Data Science;Neurosciences;Pain Research;Pediatric

ORG_CITY: DURHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Pain in children is common and inadequately treated due to the paucity of rigorous clinical trials and the absence of a sustainable research and data ecosystem for pediatric pain. This proposal represents a partnership between Duke Clinical Research Institute and The University of Utah. We will leverage our complementary strengths to establish the Duke-Utah HEAL KIDS Pain Resource and Data Center to ensure successful completion of pediatric acute pain trials and generation of high-quality, accessible data.

PI_NAMEs: BENJAMIN, DANIEL K.;GREENBERG, RACHEL G (contact);SWARD, KATHERINE ANN;WATT, KEVIN M

PROGRAM_OFFICER_NAME: JENKINS, TAMMARA L

PROJECT_TERMS: Acute;Acute Pain;Address;adverse outcome;Award;biomedical informatics;Child;Childhood;chronic pain;Clinical;Clinical Data;Clinical Pharmacology;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;Complex;Consultations;Data;Data Analyses;data centers;Data Coordinating Center;data curation;data ecosystem;data harmonization;data infrastructure;data management;data sharing;data standards;data submission;design;Diagnosis;Discipline of Nursing;Doctor of Philosophy;Ecosystem;effectiveness research;electronic data;Ensure;Epidemiologist;experience;Faculty;Foundations;Funding;Future;Generations;Goals;healing;Helping to End Addiction Long-term;improved;Informatics;informatics tool;Information Systems;Infrastructure;innovation;Intervention;Joints;Knowledge;Leadership;Life;Logistics;Measurement;mental development;Mental disorders;Modeling;Multi-Institutional Clinical Trial;National Center for Advancing Translational Sciences;Neurocognitive;operation;opioid use disorder;Outcome;Pain;Pain management;pain perception;Pain Research;pediatric department;pediatrician;Pharmacologic Substance;Positioning Attribute;prevent;Principal Investigator;Procedures;professor;programs;Public Health;Recording of previous events;repository;Research;research data dissemination;Research Design;Research Institute;Research Personnel;Resources;Science;Site;Specific qualifier value;Structure;success;tool;United States;United States National Institutes of Health;Universities;Utah;Vision;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-N (51)]


ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative    Together,  our  experiments  will  define  individual  and  collective  behaviors  of  osteoblasts  during  bone  regeneration,  and  they  will  reveal  new  molecular  mechanisms  responsible  for  key  behaviors.    Our  experiments  will  uncover  general  principles  of  regeneration  and  will  reveal  processes  that  are  potentially  important for stimulating bone regeneration in clinical settings.

PI_NAMEs: DI TALIA, STEFANO  (contact);POSS, KENNETH D

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Adult;Age;American;Automobile Driving;Behavior;Biography;Biosensor;bone;Bone Diseases;bone imaging;Bone Matrix;Bone Regeneration;cell behavior;Cell division;Cell Proliferation;Cells;Cessation of life;Chemicals;Clinical;Competence;Complex;Computer Analysis;craniofacial development;Cytoskeleton;Data Set;Daughter;Dermal;economic impact;Embryo;Epithelial Cells;Event;experimental study;Extracellular Signal Regulated Kinases;FGF12 gene;Fracture;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic approach;Genetic Transcription;Goals;Growth;Growth Factor;Heterogeneity;Hypertrophy;Image;imaging modality;imaging platform;improved;in vivo imaging;Individual;Injury;insight;Jaw;Label;Laboratories;Life;Ligands;limb amputation;Limb structure;Link;live cell imaging;Maps;mathematical model;Mediating;member;Messenger RNA;Methodology;Methods;migration;Mitogens;Modeling;Molecular;Molecular Genetics;Monitor;Morphogenesis;Natural regeneration;novel;Osteoblasts;Osteoclasts;Pathway interactions;Pattern;pharmacologic;Population;Primordium;Process;programs;Proliferating;Protein Analysis;Publishing;regeneration potential;Regenerative capacity;regenerative growth;Regulation;response;Risk;Signal Transduction;single cell sequencing;Skeletal bone;Skin;socioeconomics;spatiotemporal;Structure;System;Testing;Tissues;transcription factor;transcriptome;transcriptomic profiling;Transgenic Organisms;transmission process;Trauma;Travel;Work;Zebrafish

PROJECT_TITLE: LIVE IMAGING OF BONE REGENERATION IN ZEBRAFISH

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE Type 1 diabetes (T1D) is caused by autoimmune attack of pancreatic beta cells. Our proposed work will define the role of PTPN22 in controlling the balance of pathogenic and regulatory CD4 T cells in T1D, leading to a better understanding of the genetic basis of this disease.

PI_NAMEs: CHEN, YI-GUANG  (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Acceleration;Adaptive Immune System;Alleles;Antigen-Presenting Cells;Autoimmune Diabetes;Autoimmune Diseases;autoimmune pathogenesis;Autoimmunity;autoreactive T cell;autoreactivity;Beta Cell;blood glucose regulation;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Clone Cells;Complex;cytokine;cytotoxic CD8 T cells;Defect;Development;diabetes control;Diabetes Mellitus;diabetes pathogenesis;diabetic;diabetogenic;Disease;Effector Cell;Environmental Risk Factor;Equilibrium;experimental study;Flow Cytometry;FOXP3 gene;Frequencies;Genetic;Genetic Predisposition to Disease;genetic risk factor;Human;immunogenic;Inbred NOD Mice;Infiltration;Inflammatory;inflammatory milieu;Injections;Innate Immune System;insight;Insulin;Insulin-Dependent Diabetes Mellitus;interleukin-21;islet;Knock-in;loss of function;Lymphoid Tissue;Mus;mutant;Nature;Non obese;Pathogenicity;Patients;Peptide/MHC Complex;Phenotype;Population;Proliferating;PTPN22 gene;Regulatory T-Lymphocyte;Reporting;Resistance;risk variant;Role;single-cell RNA sequencing;Site;Structure of beta Cell of islet;Testing;Variant;Work

PROJECT_TITLE: PTPN22 controls the interrelationship of IL-21+ and FOXP3+ CD4 T cells in T1D

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-S (02)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Sleep Research

ORG_CITY: WALTHAM

ORG_DEPT: BIOLOGY

ORG_NAME: BRANDEIS UNIVERSITY

PHR: Project Narrative Lack of sleep has adverse consequences for memory formation in both humans and animals. We have found that sleep deprivation in Drosophila causes specific defects in dopamine dynamics in the memory circuit, impairing short-term and protein synthesis-dependent memory formation. In this proposal we will uncover the molecular and circuit mechanisms by which sleep deprivation disrupts learning and design interventions to reverse them.

PI_NAMEs: GRIFFITH, LESLIE C (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: adverse outcome;Affect;Animals;Behavioral;Binding;Biochemical Pathway;Brain;calmodulin-dependent protein kinase II;Cells;Chronic;cognitive process;Conditioned Stimulus;Consensus;cost;Data;Defect;Detection;Dopamine;Drosophila genus;economic impact;Event;Failure;fly;Functional disorder;Genetic;Heart;Hour;Human;Impairment;insight;Knowledge;Learning;lens;Link;long term memory;Mammals;MAP Kinase Gene;Mediating;Memory;memory encoding;Mental disorders;Molecular;Mushroom Bodies;Nature;neural circuit;Neurons;Pathology;Pathway interactions;Preparation;prevent;Process;Protein Biosynthesis;Public Health;Punishment;rational design;Regulation;Rest;Rewards;Role;sensory input;Short-Term Memory;Signal Transduction;Sleep;Sleep Deprivation;Sleep disturbances;Societies;Stimulus;Structure;Testing;therapy design;Thinking;Time;tool;Training;Translations;Visualization;Work

PROJECT_TITLE: Regulation of Intrinsic Plasticity in Neural Circuits

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Autoimmune Disease;Lung;Orphan Drug;Prevention;Pulmonary Fibrosis;Rare Diseases;Scleroderma

ORG_CITY: CHARLESTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: NARRATIVE Pulmonary fibrosis is a terminal complication of diseases such as idiopathic pulmonary fibrosis (IPF) and systemic sclerosis (SSc). We have identified peptides with anti-fibrotic activity that are effective at blocking and reversing lung fibrosis. We propose identify a lead candidate peptide for the treatment of pulmonary fibrosis.

PI_NAMEs: FEGHALI-BOSTWICK, CAROL A. (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Amino Acids;Bleomycin;C-terminal;Cause of Death;Cessation of life;chemical synthesis;Clinic;Collagen;Collagen Type XVIII;comparative efficacy;Complement Factor B;Complication;Connective Tissue Diseases;cost;Data;Developed Countries;Development;Digestion;Disease;Disease Progression;Dose;Early Diagnosis;effective therapy;efficacy evaluation;Emotional;Endostatins;Ensure;Environment;Environmental and Occupational Exposure;Environmental Risk Factor;Extracellular Matrix;Failure;FDA approved;Fibrosis;Financial Hardship;Frequencies;Genetic;Goals;Health Care Costs;Homeostasis;Human;human disease;human tissue;Hydroxyproline;idiopathic pulmonary fibrosis;In Vitro;in vitro activity;in vivo;Infection;intraperitoneal;Lead;lead candidate;Lung;Lung Transplantation;Malignant Neoplasms;manufacture;Mass Spectrum Analysis;Messenger RNA;Morbidity - disease rate;mortality;Mus;Oral;Organ;Organ Culture Techniques;Organ failure;Organ Transplantation;Patients;Pepsin A;Peptides;Pharmaceutical Preparations;Pre-Clinical Model;prevent;Profibrotic signal;prophylactic;Pulmonary Fibrosis;Radiation therapy;Regimen;response;side effect;Skin;Stomach;Structure of parenchyma of lung;synthetic peptide;Systemic Scleroderma;Testing;Therapeutic;Transforming Growth Factors;Translating;Variant

PROJECT_TITLE: Peptides for the treatment of pulmonary fibrosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-F (M1)]


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Proposed studies will define the role of HIPK2 signaling in pulmonary vascular remodeling and pulmonary arterial hypertension (PAH); will provide insights into the molecular mechanisms that are important in pathogenesis of PAH; and will explore whether HIPK2 could serve as a novel molecular target for therapeutic intervention.

PI_NAMEs: KUDRYASHOVA, TATIANA V (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Abnormal Cell;Apoptosis;Area;Attenuated;Automobile Driving;Cell Death;cell growth;Cell Proliferation;Cell Survival;Centrosome;Cessation of life;conditional knockout;Cytokinesis;Data;Development;Disease;Disease Progression;Distal;Event;experimental study;Extracellular Matrix;Growth;homeodomain;Human;Impairment;improved;In Vitro;in vivo;Induction of Apoptosis;insight;Knock-out;Knowledge;Link;Lung;Malignant Neoplasms;Medial;Modeling;Molecular;Molecular Target;molecular targeted therapies;Mus;novel;novel therapeutic intervention;Outcome;overexpression;Pathogenesis;Pathologic;patient prognosis;Patients;pharmacologic;Phenotype;Phosphotransferases;prevent;Proliferating;Protein Kinase Interaction;Proteins;Publishing;pulmonary arterial hypertension;pulmonary arterial pressure;Pulmonary arterial remodeling;Pulmonary artery structure;Pulmonary Hypertension;pulmonary vascular cells;pulmonary vascular remodeling;Rattus;Regulation;Research;Resistance;right ventricular failure;Role;Signal Pathway;Signal Transduction;Smooth Muscle;Smooth Muscle Myocytes;Structure of parenchyma of lung;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;tissue culture;Tissue Sample;Transcription Coactivator;Transgenic Mice;Up-Regulation;vascular factor;Vascular remodeling;Vascular Smooth Muscle;vascular smooth muscle cell proliferation;Ventricular

PROJECT_TITLE: HIPK2 signaling in Pulmonary Arterial Hypertension

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Precision Medicine

ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: This project aims to systematically investigate the molecular mechanisms of brain senescence in different molecular subtypes of Alzheimer's Disease (AD) for discovery of novel targets and therapeutics for AD using cutting edge systems biology and single cell sequencing technologies as well as extensive in vivo experiments.

PI_NAMEs: ORR, MIRANDA ETHEL;ZHANG, BIN  (contact)

PROGRAM_OFFICER_NAME: PETANCESKA, SUZANA

PROJECT_TERMS: age related;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;Artificial Intelligence;ATAC-seq;Attention;Autopsy;Back;Bioinformatics;biological adaptation to stress;Biology;Brain;brain tissue;cell injury;Cell Nucleus;cell type;Cells;Cellular Morphology;Characteristics;Chemicals;Chromatin;Chronic;Cognitive deficits;Communities;comorbidity;Complex;Data;Data Set;Dementia;Development;Disease;disease heterogeneity;disorder subtype;drug candidate;drug repurposing;Drug usage;Environment;Exhibits;experimental study;Family;FDA approved;Gene Expression;Genes;Genetic;Goals;hallmarks of aging;Heterogeneity;Hippocampus;Human;Image;improved;in silico;in vivo;in vivo Model;Inflammation;Investigation;Link;Machine Learning;Maps;Methodology;Molecular;Molecular Profiling;molecular scale;molecular subtypes;mouse model;multidisciplinary;Multiomic Data;multiple omics;nano-string;Neighborhoods;network models;Neurofibrillary Tangles;neuropathology;novel;novel therapeutics;Outcome;Participant;Pathogenesis;Pathology;patient response;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phenotype;Portraits;Positioning Attribute;Procedures;Process;protein expression;proteogenomics;Proteomics;Research;research clinical testing;Resolution;response;Scientist;senescence;senescent cell;senolytics;single cell sequencing;single-cell RNA sequencing;Study Subject;Systems Biology;tau Proteins;Technology;Testing;Therapeutic;Tissues;tool;transcriptome;transcriptome sequencing;transcriptomics;treatment response;treatment strategy;Validation

PROJECT_TITLE: Identification and Characterization of Senescent Cells in Molecular Subtypes of Alzheimer's Disease

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: HADLEY

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: Project Narrative This proposal aims to develop an ultra-flexible and stretchable bioelectronic microarchitecture system converged with an integrated artificial capillary network and a feedback sensing network. This system is designed to be seamlessly embedded in 3D cardiac microtissues and organoids, enabling efficient 3D delivery of essential media and providing real-time feedback on cellular activities throughout tissue development. The successful implementation of this technology is expected to substantially improve cardiac tissue development and maturation, enhancing tissue models for biomedical research and therapeutic applications.

PI_NAMEs: YAO, JUN  (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: 3-Dimensional;3D Print;Address;bioelectronics;biomaterial compatibility;Biomedical Research;Blood capillaries;Cardiac;cardiac tissue engineering;cardiogenesis;Cell Maturation;Cells;Circulation;Data Analytics;design;Development;Dimensions;disease model;Drug Delivery Systems;drug testing;Electrodes;Electronics;Electrophysiology (science);Environment;Feedback;flexibility;functional improvement;Goals;Heart;Heart Diseases;Human;human induced pluripotent stem cells;human morbidity;human mortality;Impairment;improved;In Situ;In Vitro;induced pluripotent stem cell derived cardiomyocytes;intimate behavior;Link;lithography;Liver;Location;Metals;Methods;Microfabrication;Microfluidics;Modeling;Molds;Molecular;molecular phenotype;Monitor;Morbidity - disease rate;mortality;multimodality;neural;Nutrient;Organ;Organogenesis;Organoids;Outcome;Oxygen;Pancreas;Performance;Perfusion;Phenotype;Physiological;prevent;Printed Media;Research;Resolution;sensor;success;System;technology validation;Therapeutic;Time;Tissue Engineering;Tissue Model;Tissues;transcriptomics;Translating;Transplantation;Vascular System;Work

PROJECT_TITLE: Flexible bioelectronics platform converging capillary-like delivery network and sensing feedback network for improving cardiac tissue engineering

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-O (M1)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: Newark

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative The internal protein encoded by betacoronaviruses showed virus-specific roles in pathogenesis and replication. The objectives of this application are to determine if the I protein functions in a virus-specific context and to delineate the immunological and/or virological roles of I protein in determining viral kinetics and virulence.

PI_NAMEs: WONG, LOK-YIN ROY  (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;Ablation;Acceleration;Address;Attenuated;attenuation;betacoronavirus;Binding;Biological Assay;Blocking Antibodies;Blood;Bronchoalveolar Lavage;Cell Physiology;Cells;Code;Coronavirus;cytokine;Disease;Disease Outbreaks;disorder prevention;Disparate;Edema;Electron Microscopy;Exhibits;experimental study;Family;Gene Expression;Genes;Genetic;Goals;health economics;Health system;Homeostasis;Human;human coronavirus;Immune;Immune Evasion;Immune response;Immunologics;Immunology;Immunoprecipitation;immunoregulation;In Vitro;in vivo;Infection;Infiltration;Inflammatory;interferon alpha receptor;Interferons;Intervention;K-Series Research Career Programs;Kinetics;Knockout Mice;Life Cycle Stages;Lung;lung injury;Maps;Mass Spectrum Analysis;Measures;Mediating;member;Membrane;Middle East Respiratory Syndrome;Middle East Respiratory Syndrome Coronavirus;Molecular;mouse model;Murine hepatitis virus;Mus;mutant;Nucleocapsid;Open Reading Frames;pandemic disease;Parents;Pathogenesis;Pathogenicity;Phenotype;Play;Population;Production;Property;Protein Deficiency;protein expression;protein function;Proteins;Public Health;recombinant virus;Replicon;Reporting;Research;reverse genetics;Role;SARS coronavirus;Signal Transduction;single-cell RNA sequencing;skills;System;Techniques;Training;Up-Regulation;Viral;Viral Genes;Viral Proteins;viral RNA;Virion;Virulence;Virulence Factors;Virulent;Virus;Virus Replication;Virus-like particle;Visualization

PROJECT_TITLE: Phenotypic and functional characterization of Betacoronavirus Internal protein in relation to virulence

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Neurosciences;Opioids;Pain Research;Pediatric;Rare Diseases

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Children with acute respiratory failure (ARF) require invasive mechanical ventilation (MV) – an intrusive, painful, lifesaving procedure. They universally receive high-dose opioids, yet still experience episodes of acute pain. Optimizing Pain Treatment In Children On Mechanical ventilation (OPTICOM) is a well-designed large-scale randomized controlled trial that will define the effectiveness of supplementing opioids with acetaminophen and/or ketorolac at (i) reducing pain and (ii) decreasing opioid exposure in this vulnerable population.

PI_NAMEs: BELL, MICHAEL J;HOLUBKOV, RICHARD ;TRAUBE, CHANI  (contact)

PROJECT_TERMS: Absence of pain sensation;Acetaminophen;Acute Pain;Acute pain management;Acute respiratory failure;Address;Adjuvant;Adjuvant Therapy;Admission activity;Adult;Adverse effects;Affect;Age;Analgesics;arm;Assessment tool;Black race;Breakthrough Pain;Caring;Child;Childhood;chronic pain;Clinical;Clinical Practice Guideline;Clinical Trials;Cognitive;Common Data Element;Critical Care;Critically ill children;Data Coordinating Center;Delirium;design;Dose;Double-Blind Method;Drug Kinetics;Effectiveness;Enrollment;Ensure;Environment;Ethics;Event;evidence base;experience;Exposure to;Family;Funding;Geography;Goals;Guidelines;health disparity;high risk population;Hispanic;Hour;improved;improved outcome;Infrastructure;innovation;Intravenous;Ketorolac;Knowledge;Length;Life;Measures;Mechanical ventilation;medical vulnerability;Methodology;milligram;Mission;Monitor;Morphine;National Institute of Child Health and Human Development;non-opioid analgesic;Observational Study;Operative Surgical Procedures;opiate tolerance;Opioid;opioid exposure;opioid withdrawal;Outcome;Pain;Pain management;pain reduction;Pain Research;pain score;patient population;Patients;Pediatric Intensive Care Units;Pharmaceutical Preparations;Placebo Control;Placebos;Population;Population Heterogeneity;Positioning Attribute;Prevention;Procedures;programs;Race;Randomized;Randomized, Controlled Trials;Research;Resources;Risk;Sedation procedure;sedative;Site;socioeconomics;standard of care;Testing;treatment group;Underrepresented Populations;underserved area;United States;Vulnerable Populations;Well in self;Withdrawal;Work


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Physical Activity;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: EAST LANSING

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

ORG_STATE: MI

PHR: African American emerging adults (ages 18-30) are disproportionately impacted by asthma, but have been under-represented in research. Mobile asthma management interventions may help improve asthma control and allow people to live healthier lives. During this project, we will use an innovative strategy to develop an optimized mobile asthma management intervention using the most effective combination of nurse-delivered asthma education, a smart phone app, and text messaging.

PI_NAMEs: BAPTIST, ALAN P. (contact);MACDONELL, KAREN

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Accountability;Address;Adherence;Adolescence;Adult;African American;Age;Algorithms;Ambulatory Care;American;American Lung Association;Asthma;Attitude;Behavior;behavior test;Behavior Therapy;Behavioral;Blinded;Cellular Phone;Child Care;Clinic;Clinical Research;clinically significant;Computational algorithm;Computers;cost;Data Collection;Decision Making;design;Education;Educational Intervention;efficacy evaluation;emerging adult;emerging adulthood;Engineering;experience;Experimental Designs;experimental study;Goals;Guidelines;Human;improved;Individual;Informal Social Control;innovation;International;Intervention;intervention delivery;Knowledge;Mediator;Medical center;medication compliance;meetings;mhealth interventions;Modeling;Morbidity - disease rate;mortality;Motivation;motivational enhancement therapy;Multicenter Trials;multiphase optimization strategy;Nurses;Participant;Persons;Physical activity;Play;Population;post intervention;programs;Quality of life;Randomized;randomized, clinical trials;Recommendation;recruit;Regimen;Research;Research Design;Resources;Risk Taking;Role;Sample Size;Schools;secondary outcome;Self Efficacy;Self Management;Site;skills;smartphone application;Symptoms;System;Target Populations;Technology;Testing;Text Messaging;theories;Time;treatment arm;Universities;virtual;Voice;wearable device;Work

PROJECT_TITLE: Asthma and Technology in Emerging African American Adults (The ATHENA Project)

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Narrative: The correct segregation of the genomic material during cell division is an important process, which is fundamental to life and any segregation error has severe implications for the organisms. By providing unique and novel information on the spindle structure and function we will gain a better understanding of the forces and mechanisms involved in the process of chromosome segregation and ultimately healthy mitotic spindles. The data acquired in the frame of this proposal will be valuable to identify new therapeutic approaches and targets.

PI_NAMEs: REDEMANN, STEFANIE  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Anaphase;Cell division;Chromosome Segregation;Chromosomes;Complement;Data;daughter cell;Development;Genomics;Goals;Health;Human;Kinetochores;Life;life span;Light;mathematical model;Metaphase Plate;Microscopic;Microtubules;Mitosis;Mitotic spindle;Molecular;Monitor;mutant;novel;novel therapeutic intervention;Organism;Play;Positioning Attribute;Process;Property;Research;Role;segregation;Structure;targeted cancer therapy;Testing;Time;tomography

PROJECT_TITLE: The role of microtubule dynamics in midzone driven chromosome segregation in anaphase

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cannabinoid Research;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Depression;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Pain Research;Pediatric;Serious Mental Illness;Substance Misuse

ORG_CITY: CORAL GABLES

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE  Our overall goal is to better understand the neural and psychiatric effects of comorbid cannabis use in adolescent depression—two major public health concerns associated with long-term consequences. A prospective multimodal study will test the overall hypothesis that adolescent cannabis use and depression have additive effects, leading to worse clinical outcome and inducing alterations in reward and pain neurocircuits over a 2-year follow-up. By focusing on these predictive relationships, we seek to comprehensively understand the impact of cannabis use in depressed adolescents on both the neurocircuitry and clinical outcome dimensions.

PI_NAMEs: GABBAY, VILMA  (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Address;Adolescence;Adolescent;Alcohol consumption;Amygdaloid structure;Analgesics;Anhedonia;Anterior;behavioral construct;Binding;Blood;Brain;cannabinoid receptor;Cannabinoids;Cannabis;child depression;Chronic;chronic depression;Clinical;cohort;comorbid depression;comorbidity;Corpus striatum structure;Data;design;Dimensions;Disease;Epidemiology;Exclusion;experience;Family;follow-up;Functional Magnetic Resonance Imaging;Future;Goals;graph theory;Habenula;illicit drug use;Image;imaging modality;improved;Insula of Reil;Intervention;Knowledge;Link;machine learning method;Maps;marijuana use;Mental Depression;Methodology;midbrain central gray substance;Modeling;mood symptom;Morbidity - disease rate;multimodality;neural;neural circuit;neuroimaging;nicotine use;novel;Nucleus Accumbens;Outcome;Pain;pain symptom;Pattern;pleasure;Prevention strategy;Process;programs;prospective;psychiatric comorbidity;Public Health;Recording of previous events;Research;research clinical testing;Resolution;Rest;reward anticipation;reward circuitry;reward dysfunction;Rewards;Risk;Role;secondary outcome;Severities;sex;Signal Transduction;Structure;substance use;Substance Use Disorder;suicidal;Suicide;Surveys;Symptoms;System;Teenagers;Testing;Tetrahydrocannabinol;Thalamic structure;Trauma;Urine;Ventral Tegmental Area;Vulnerable Populations;Work;Youth

PROJECT_TITLE: Neural and Psychiatric Consequences of Cannabis Use in Adolescents

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Hematology;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: Chicago

ORG_DEPT: CHEMISTRY

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: NARRATIVE Acute lymphoblastic leukemia (ALL) is the most common hematological malignancy and the leading cause of cancer-related death in children in the United States. The MEK signaling pathway plays a key role in the progression of T-cell ALL (T-ALL). We have demonstrated that MEK7 is upregulated in this disease, and it causes disease progression by upregulating another kinase, JNK. We plan to develop selective inhibitors for MEK7 to study the activity of these kinases in T-ALL in vivo. This advance will allow for unique insights delineating the role of MEK7 in T-ALL and validating these kinases as potential new drug targets.

PI_NAMEs: LACORAZZA, DANIEL ;SCHEIDT, KARL A (contact);SCHILTZ, GARY E

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Acute Lymphocytic Leukemia;Acute T Cell Leukemia;acute T-cell lymphoblastic leukemia cell;Address;angiogenesis;arm;Attenuated;Binding;Biochemical;biological adaptation to stress;Biological Assay;Biophysics;Cancer Etiology;Cell Survival;Cells;Cellular Assay;Chemicals;chemotherapy;Child;childhood cancer mortality;Childhood Leukemia;Childhood Precursor T Lymphoblastic Leukemia;clinically relevant;Computer Models;cytokine;design;Development;Disease;Disease Progression;Disease remission;Disease-Free Survival;Dissection;Dose;Drops;Drug Targeting;environmental stressor;Enzymes;epigenetic silencing;Eukaryota;Event;Experimental Leukemia;experimental study;extracellular;Family;FDA approved;Functional disorder;gene repression;Genes;Genetic Transcription;GKLF protein;Growth Factor;Hematologic Neoplasms;Hormones;Human;Immune;improved;In Vitro;in vivo;Indazoles;Inflammatory Response;inhibitor;insight;kinase inhibitor;Knowledge;Lead;leukemia;Malignant Neoplasms;MAP Kinase Modules;MAP2K1 gene;MAPK3 gene;MAPK8 gene;Measures;Mediating;Methylation;Mitogen-Activated Protein Kinase Inhibitor;Mitogen-Activated Protein Kinase Kinases;Mitogen-Activated Protein Kinases;Molecular;Motility;mouse model;N-terminal;new therapeutic target;NF-kappa B;novel;Oncogenes;Pathology;Pathway interactions;patient derived xenograft model;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacologic Substance;Phosphorylation;Phosphotransferases;Physiological;Play;Process;Prognosis;programs;Proliferating;Property;Protein Isoforms;rational design;Recurrent disease;Refractory Disease;Repression;Role;screening;Series;Signal Pathway;Signal Transduction;structural biology;Structure;synergism;targeted treatment;Testing;Time;tool;Toxic effect;transcription factor;Tumor Suppressor Proteins;United States;Up-Regulation;Work;Yeasts;Zinc Fingers

PROJECT_TITLE: A Molecular Approach to Dissecting MEK-Mediated Phosphorylation in Pediatric Leukemia

STUDY_SECTION: CBP

STUDY_SECTION_NAME: Chemical Biology and Probes Study Section[CBP]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Women's Health Research

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: Project Narrative The proposed study will adapt and evaluate CARES, an intervention that aims to prevent HIV among adolescent girls and young women by increasing their use of pre-exposure prophylaxis (PrEP) methods. We will test whether CARES increases PrEP use and whether it is acceptable and feasible to implement in real-world programmatic settings in Zimbabwe and South Africa. If successful, the study will provide an effective tool to support PrEP use in this priority population and ensure that CARES ideally positioned for scale-up to programs throughout the region.

PI_NAMEs: ATUJUNA, MILLICENT ;MGODI, NYARADZO ;ROBERTS, SARAH TYLER (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;Adherence;Affect;Africa South of the Sahara;AIDS prevention;Biological Markers;Chicago;Clinic;Clinical;Clinical Research;Clinical Trials;Collaborations;cost;Counseling;Country;Data;design;Development;Educational workshop;effectiveness evaluation;effectiveness testing;empowerment;Ensure;Evaluation;experience;Feedback;Female Adolescents;Focus Groups;Foundations;Goals;HIV;Illinois;implementation evaluation;implementation science;Incidence;informant;Injectable;International;Interruption;Intervention;Interview;Life;member;Methods;Microbicide Trials Network;Modality;Oral;Outcome Assessment;Participant;Phase;Policy Maker;Population;Positioning Attribute;post implementation;pre-exposure prophylaxis;preservation;prevent;prevention effectiveness;primary outcome;Principal Investigator;Process;programs;Provider;Public Health;Qualitative Methods;Qualitative Research;Randomized;Records;Research;Resources;Review Literature;scale up;secondary outcome;Series;Site;South Africa;Structure;success;Surveys;Telephone;Testing;Time;tool;Trust;Uganda;Universities;Visit;Work;young woman;Youth;Zimbabwe

PROJECT_TITLE: CARES: An adherence support intervention for multiple PREP methods among adolescent girls and young women in South Africa and Zimbabwe

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-H (50)]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Childhood Leukemia;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE (unchanged from initial application) Leukemia remains difficult to treat, indicating an urgent need to develop new therapeutic strategies; thus, the overarching goal of the proposed research is to explore leukemia metabolism and develop novel biomarkers and therapeutic strategies. Our preliminary data demonstrates that specific metabolic pathways driving serine biosynthesis are increased in leukemia; these reflect vulnerabilities that we can develop imaging biomarkers to target. Our proposed work will facilitate future patient-specific treatment planning and novel experimental strategies for cancer treatment.

PI_NAMEs: KESHARI, KAYVAN R (contact);KHARAS, MICHAEL

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Anabolism;Automobile Driving;Biological Markers;cancer therapy;Carbohydrates;Carbon;Cell Compartmentation;cell growth;Cell Line;Cells;Cellular Metabolic Process;chemotherapy;Clinical;Collaborations;Companions;Complex;Data;dehydroascorbate;Dependence;design;Development;Diet;Disease;Environment;Enzyme Inhibition;Enzymes;FLT3 gene;Future;Genetic;Genetic Variation;Glucose;Glutamine;Glycolysis;Goals;Hematopoietic;Heterogeneity;Human;human cord blood CD34+ cell;Image;imaging approach;imaging biomarker;in vivo;individualized medicine;innovation;insight;Isocitrate Dehydrogenase;Isotopes;Knowledge;leukemia;leukemic stem cell;Link;Lipids;Magnetic Resonance;Magnetic Resonance Imaging;Malignant Neoplasms;mass spectrometric imaging;Measures;Mediating;Metabolic;metabolic abnormality assessment;metabolic imaging;Metabolic Pathway;Metabolism;MLL-AF9;Modeling;Motivation;Mus;Mutation;Myeloid Leukemia;new therapeutic target;novel;novel marker;novel strategies;novel therapeutic intervention;novel therapeutics;Nutrient;Organism;overexpression;Oxidation-Reduction;Oxidative Stress;Oxidative Stress Induction;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phosphoglycerate dehydrogenase;programs;Publishing;Pyruvate;Relapse;Research;Resistance;response;Role;Sampling;Science;Serine;Sorting;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;stem cell biology;stem cells;stemness;stress state;Therapeutic;therapeutic development;therapy resistant;tool;Translating;treatment planning;treatment response;tumor metabolism;Visualization;Work

PROJECT_TITLE: Interrogation of the oxidative-stress-induced leukemia program in vivo usingmetabolic imaging


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Epilepsy;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: ORANGEBURG

ORG_NAME: NATHAN S. KLINE INSTITUTE FOR PSYCH RES

PHR: PROJECT NARRATIVE  This project intends to significantly advance our understanding of Alzheimer's disease (AD) by focusing on an aspect of the disease that occurs early: hyperexcitability. We hypothesize that hyperexcitability develops first in the hippocampal dentate gyrus (DG) which would be a paradigm shift; we will address the hypothesis using state-of-the-art methods for selective DG silencing in mouse models of AD. We also will test a novel mechanism for the generation of DG hyperexcitability.

PI_NAMEs: SCHARFMAN, HELEN E (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Abeta clearance;abeta deposition;Acetylcholine;Action Potentials;activity marker;Address;Adult;Age;Age Months;age related changes;Alzheimer's Disease;Alzheimer's disease model;Amyloid beta-Protein;Animals;Area;Attention;axonal sprouting;Brain;Carbachol;Cells;cholinergic;cholinergic neuron;Chronic;Clinical Research;Cognition;Communities;Data;Dendrites;density;dentate gyrus;Disease;Early Intervention;Electroencephalography;Enzymes;Epilepsy;epileptiform;Event;Exhibits;experimental study;extracellular;FOS gene;Frequencies;Functional disorder;Funding;Future;Generations;Glutamates;granule cell;Hippocampus;Human;Impaired cognition;improved;in vivo;interest;Investigation;Ion Channel;Location;Medial;Mediating;Memory;memory consolidation;Memory impairment;Memory Loss;Methods;mouse model;Mus;Muscarinic Acetylcholine Receptor;Muscarinic Agonists;Muscarinics;Neurons;neuropathology;novel;optogenetics;Pathology;Play;prevent;Probability;Prosencephalon;REM Sleep;Reporting;Research;Research Personnel;research study;Rodent;Role;Seizures;Site;Sleep;Source;spatiotemporal;Synapses;Testing;Tg2576;Therapeutic;Time;Transgenic Mice;Wild Type Mouse;Work

PROJECT_TITLE: Hyperexcitability in Alzheimer's Disease

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ORG_CITY: LEXINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Lung fibrosis is a progressive, incurable disease with few treatment options. This proposal aims to define if targeting the epigenetic enzyme EZH2 using an FDA-approved drug would be a viable therapeutic option for lung fibrosis patients. The proposed research will expand our knowledge about how epi-drugs can influence important phenotypes of lung disease.

PI_NAMEs: BRAINSON, CHRISTINE FILLMORE (contact)

PROJECT_TERMS: allergic airway disease;Alveolar;Alveolar Cell;Attenuated;Biological Availability;Biological Models;Bleomycin;Cell Culture Techniques;Cell Lineage;Cell Reprogramming;cell type;Cells;chemotherapy;ChIP-seq;Chromatin;Cicatrix;Collagen;Complex;cytokine;Cytokine Signaling;Data;Dependovirus;derepression;Development;Disease;Disease Progression;DNA Sequence Alteration;Down-Regulation;Enzymes;Epigenetic Process;epigenetic therapy;Epithelial Cells;Epithelium;EZH2 gene;FDA approved;Fibroblasts;Fibrosis;Flow Cytometry;FOXP2 gene;Gene Expression;Genes;Genetic Transcription;Harvest;Histologic;Histology;Histone H3;histone methyltransferase;Human;Immune;improved;in vivo;in vivo Model;Infection;Inflammatory;inhibitor;Injury;insight;Interleukin-1 beta;Intervention;knock-down;Knowledge;Laboratories;Life;LoxP-flanked allele;Lung;Lung Diseases;lung injury;lung repair;Lysine;Medicine;Mesenchymal;Methylation;Modeling;Mus;Myeloid Cells;novel therapeutic intervention;Oral;Organoids;overexpression;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Phenotype;Polycomb;Population;prevent;Prevention;profibrotic cytokine;promoter;Pulmonary Fibrosis;pulmonary function;Pulmonary function tests;Radiation;Repression;Research;response;Role;Sampling;Signal Transduction;Silicon Dioxide;single-cell RNA sequencing;small molecule;Stains;stem cell biology;Supporting Cell;System;Testing;Therapeutic;Tissues;transcription factor;transcriptome sequencing;Transforming Growth Factor beta;Up-Regulation;Viral;Western Blotting

PROJECT_TITLE: Targeting Lung Fibrosis Using Epigenetic Therapy

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative Herein, we will utilize photo- and electrochemical single electron transformations to gain access to biologically relevant molecules. Through the synthesis of novel chemical building blocks, the generation of valuable bond disconnections, and the merger of complementary reaction platforms, this proposal provides innovations in efficiency and economy which are directly translatable to the discovery of small molecule therapeutics.

PI_NAMEs: STEPHENSON, COREY  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Free radical strategies for bioactive molecule synthesis

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE This study will determine how the immune cells of the brain, known as microglia, change the synaptic connections between nerve cells in the brain. We will test the hypothesis that microglia engulf and remodel a lattice-like structure between cells known as the extracellular matrix. This novel mechanism could help explain how immune signals can impact the formation of long-term memories.

PI_NAMEs: MOLOFSKY, ANNA V (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Address;Adult;aggrecan;Alzheimer's Disease;Animals;Astrocytes;Brain;brain cell;brain parenchyma;Brain region;brain remodeling;brevican;Calcium;Cells;Chondroitin Sulfate Proteoglycan;Cognition Disorders;Communication;conditioned fear;cytokine;Data;Dendritic Spines;Dependence;Development;Discrimination;Disease;excitatory neuron;experience;Extracellular Matrix;Extracellular Matrix Proteins;Family;fear memory;Filopodia;Fright;frontal lobe;gain of function;glial activation;Goals;Head;Hippocampus;Homeostasis;Image;Immune;Immune signaling;Immune system;Immune System Diseases;Impaired cognition;Impairment;inhibitory neuron;interest;Interleukin-1;Interleukins;Interneurons;Learning;Link;long term memory;Macrophage;Matrix Metalloproteinases;Mediating;Memory;memory consolidation;memory encoding;memory recall;memory retrieval;Microglia;Molecular;Mus;Nerve Degeneration;Neurodegenerative Disorders;neurogenesis;neuronal patterning;Neurons;neurotransmission;novel;optogenetics;Outcome;Parvalbumins;Pathway interactions;Pattern;Peptide Hydrolases;Phagocytes;Population;Process;Publishing;receptor;recruit;Regulation;response;Role;Schizophrenia;Shapes;Signal Pathway;Signal Transduction;Stress;Structure;Synapses;Synaptic plasticity;synaptogenesis;Testing;Time;Tissues;Training;transcriptome sequencing;Traumatic Brain Injury;Vertebral column;Work

PROJECT_TITLE: Microglial remodeling of the extracellular matrix in memory circuits

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Microbiome;Substance Misuse

ORG_CITY: Auburn

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: AUBURN UNIVERSITY AT AUBURN

ORG_STATE: AL

PHR: Project Narrative: The proposed research is relevant to public health because it will provide new insights into the molecular mechanism of alcohol-induced intestinal barrier dysfunction and how such dysfunction exacerbates liver injury. Furthermore, identify therapeutic target and treatment strategies to alleviate bot gut and liver injury. Thus, the proposed research is relevant to NIAAA’s mission in supporting research that aims to reveal novel mechanisms, targets, and methods for treating alcohol-induced organ damage.

PI_NAMEs: THOMES, PAUL GIDEON  (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Affect;Alcohol consumption;alcohol effect;alcohol exposure;alcohol misuse;Alcoholic Liver Diseases;Alcohols;Aspirin;Attenuated;Autophagocytosis;Autophagosome;bactericide;Biogenesis;Catabolic Process;Cell Physiology;Cells;Chronic;Colon;Cytoplasm;Data;Disease Progression;dysbiosis;Endotoxemia;Enzymes;Epithelial Cells;Epithelium;Ethanol;Exhibits;Extravasation;FDA approved;feeding;Functional disorder;gastrointestinal epithelium;GTF2H1 gene;gut homeostasis;gut microbiota;Health;Heavy Drinking;Homeostasis;Impairment;insight;intestinal barrier;intestinal crypt;intestinal epithelium;Intestinal Mucosa;Intestinal permeability;Intestines;Investigation;Large Intestine;Leaky Gut;Liver diseases;liver function;liver injury;Lysosomes;macromolecule;Methods;microbial composition;microbiota;Mission;Molecular;Morbidity - disease rate;mortality;Muramidase;Mus;National Institute on Alcohol Abuse and Alcoholism;novel;Nuclear;Organ;Organelles;Organoids;Paneth Cells;Pathogenesis;preservation;Process;Public Health;Research;Research Support;Risk Factors;Role;senescence;Small intestine mucous membrane;Small Intestines;Testing;therapeutic target;transcription factor;treatment strategy

PROJECT_TITLE: Role of Intestinal Autophagy in the Pathogenesis of Alcohol Associated Liver Disease

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PHR: NARRATIVE Built on recent findings from each laboratory, the Qi and Zhao laboratories team up to investigate the role of STING and its crosstalk with a highly conserved protein quality-control mechanism known as endoplasmic reticulum (ER)-associated degradation (ERAD) in AD pathogenesis. Our central hypothesis is that chronic activation of STING-mediated innate immunity in the brain is a fundamental mechanism underlying neuroinflammation in AD pathogenesis, which is regulated by SEL1L-HRD1 ERAD. This hypothesis is supported by our strong preliminary data pointing towards the role of ERAD-STING axis in both neuroinflammation and amyloid pathology.

PI_NAMEs: QI, LING  (contact);ZHAO, ZHEN

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: 3-hydroxy-3-methylglutaryl-coenzyme A;Acceleration;age related;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid;Amyloid beta-Protein;amyloid pathology;Animal Model;Astrocytes;Autopsy;Binding;Biology;Blood Vessels;Brain;brain cell;cell type;Cells;Cellular biology;Chronic;Complex;Data;Defense Mechanisms;Dementia;Deposition;Disease;Disease Progression;driving force;Drug Design;ds-DNA;Endoplasmic Reticulum;Enhancers;Etiology;Genes;Genetic;genetic approach;Heterogeneity;Human;Immune;Immune response;Immunology;Impairment;induced pluripotent stem cell;Infection;Inflammation;Inflammatory;Injury;innate immune pathways;insight;intercellular communication;Knockout Mice;Laboratories;Link;Macrophage;Mediating;Membrane;Metabolism;Microglia;misfolded protein;Modeling;Molecular;mouse model;Mus;Natural Immunity;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;Neuronal Dysfunction;Neurons;new therapeutic target;novel;Oxidoreductase;Pathogenesis;Pathway interactions;Patients;pharmacologic;Physiological;Play;prevent;Primary Cell Cultures;protein complex;protein degradation;Proteins;Publishing;Qi;Quality Control;recruit;Regulation;Reporting;response;response to injury;Role;Sampling;Senile Plaques;Signal Transduction;Stimulator of Interferon Genes;Surveys;Synapses;tau Proteins;Testing;Ubiquitination;Virus Diseases;Yeasts

PROJECT_TITLE: ERAD-STING Crosstalk in Microglia: Unraveling the Pathogenesis of Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Z (55)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Pediatric

ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative We will develop and apply powerful statistical approaches to analyzing the dGTEx data to identify genetic variants that affect gene expressions in different tissues, cell types, and developmental stages. We will share our methods and results with the research community to better analyze and interpret results from genome-wide association studies.

PI_NAMEs: GERSTEIN, MARK BENDER;ZHAO, HONGYU  (contact)

PROGRAM_OFFICER_NAME: DAYAL, JYOTI

PROJECT_TERMS: Affect;Alleles;Bayesian Method;Blood;Brain;Catalogs;cell type;Cells;Chromatin;cohort;Communities;Complement;Complex;Computing Methodologies;Data;data integration;Data Set;deep learning;Development;Disease;early childhood;Event;experience;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Research;genetic variant;genome wide association study;Genomic Segment;Genotype-Tissue Expression Project;Human Genetics;improved;Methods;Modeling;Multiomic Data;multiple omics;Names;novel;postnatal;prepuberty;Protein Isoforms;Puberty;Quantitative Trait Loci;recruit;Research;Sample Size;Sampling;single cell sequencing;Source;Statistical Methods;success;Tissues;tool;trait;Transcript;transcriptome;transcriptome sequencing;Uncertainty;Variant;Work

PROJECT_TITLE: Computational and Statistical Methods to determine variant effect across cell types and development stages

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-W (M2)]


NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Patient Safety;Pediatric;Substance Misuse

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Each year, >5 million American children undergo surgeries including major and painful cardiac surgeries and spine fusion surgeries. More than 50% of these children experience uncontrolled severe acute surgical pain, significant opioid-related adverse outcomes including respiratory depression, persistent opioid use/misuse, opi- oid dependence, overdoses, and deaths, and chronic persistent surgical pain. Implementation of evidence-based standardized perioperative methadone-based multimodal acute surgical pain management in this clinical trial, and proactive and personalized risk identification will maximize acute surgical pain relief while minimizing opioid use, serious opioid-related adverse outcomes, and transition of acute surgical pain to chronic surgical pain in millions of children undergoing major and painful surgeries each year.

PI_NAMEs: CHIDAMBARAN, VIDYA ;SADHASIVAM, SENTHILKUMAR  (contact)

PROGRAM_OFFICER_NAME: TAYLOR-ZAPATA, PERDITA

PROJECT_TERMS: ABCB1 gene;Absence of pain sensation;Acids;Acute;Acute Pain;Adolescent;Adverse effects;adverse outcome;Age;American;antagonist;Binding Proteins;Cardiac;Cardiac Surgery procedures;Cardiopulmonary Bypass;Cessation of life;Child;Chronic;Clinical;clinical research site;Clinical Trials;CYP2B6 gene;CYP2D6 gene;Data;Dependence;Dose;Drug Kinetics;Enrollment;Epigenetic Process;Evaluation;evidence base;experience;Future;Genes;Genetic;genetic variant;Genetic Variation;Genotype;Glycoproteins;Goals;Heritability;Idiopathic scoliosis;improved;Incidence;Individual;inpatient surgery;Length of Stay;Life;Methadone;Methylation;Morbidity - disease rate;morphine equivalent;multidisciplinary;multimodality;N-Methylaspartate;Operative Surgical Procedures;Opiate Addiction;Opioid;opioid epidemic;opioid sparing;opioid use;Outcome;Overdose;Oxycodone;Pain;pain chronification;Pain management;pain relief;Perioperative;personalized risk prediction;pharmacokinetic model;Postoperative Nausea and Vomiting;Postoperative Pain;Postoperative Period;postoperative recovery;prescription opioid;profiles in patients;prospective;Protocols documentation;psychologic;Psychological Factors;Randomized;randomized, clinical trials;Reporting;Risk;risk minimization;risk prediction;risk prediction model;Safety;Sedation procedure;Specific qualifier value;Spinal Fusion;standard of care;Standardization;Surgical Management;surgical pain;Time;Variant;Ventilatory Depression

PROJECT_TITLE: Implementing and Personalizing Best-In-Class Opioid-sparing Pain Management for Major Inpatient Surgeries in Children

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-N (51)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Pediatric

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative and Relevance to Public Health  To develop efficient statistical and computational methods for understanding gene expression regulation across tissues and time points and between human and primates.

PI_NAMEs: GAO, ZIYUE ;LEE, HONGZHE  (contact)

PROGRAM_OFFICER_NAME: ARGUELLO, ALEXANDER

PROJECT_TERMS: Affect;Age;age difference;age related;Algorithmic Software;Alternative Splicing;Bioinformatics;Brain;Callithrix;cell type;Cells;Child;Childhood;Chromosome Mapping;Collaborations;comparative;comparative genomics;Complex;Computer software;computerized tools;Computing Methodologies;Data;data integration;Data Set;data visualization;Development;Developmental Biology;Dimensions;disorder risk;early childhood;Evolution;experience;Future;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic;genetic variant;Genetic Variation;Genomics;Genotype;Genotype-Tissue Expression Project;Goals;Health;Human;Human Development;Individual;Life;Macaca;Measures;Methodology;Methods;Modeling;nonhuman primate;novel;Pathway Analysis;Pathway interactions;Pattern;Personal Satisfaction;Population;postnatal;prenatal;prenatal health;prepuberty;Primates;Process;Puberty;Public Health;Quantitative Trait Loci;Regulation;Research Personnel;Resources;RNA analysis;RNA Splicing;Sampling;Software Tools;Statistical Data Interpretation;Statistical Methods;Statistical Models;Testing;Time;tissue mapping;Tissues;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Work

PROJECT_TITLE: Penn-DISAM: Data Integration and Statistical Analysis Methods for dGTEx Data


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Regenerative Medicine;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: WHITE PLAINS

ORG_NAME: WINIFRED MASTERSON BURKE MED RES INST

PHR: PROJECT NARRATIVE The proposed research is relevant to public health as the expected findings will be broadly applicable to evaluating potential therapeutic strategies for spinal cord injury, stroke, traumatic brain injury, cerebral palsy, and neurodegenerative diseases. These studies are relevant to the NIH's mission as they could have broad implications in rehabilitation and will inform future studies on motor circuit recovery.

PI_NAMEs: HOLLIS, EDMUND R (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Adverse effects;Affect;Animals;Area;awake;Axon;axon regeneration;axonal sprouting;Behavior;Calcium;central nervous system injury;Cerebral Palsy;combinatorial;cortex mapping;Data;Dendritic Spines;design;Excitatory Synapse;expectation;Forelimb;Foundations;Future;Goals;Hindlimb;Image;in vivo;in vivo imaging;Inhibitory Synapse;injured;Injury;innovation;Learning;Literature;Maps;Mediating;Methods;Mission;Motor;Motor Cortex;motor function recovery;Motor output;motor recovery;Movement;Mus;Nature;Neurodegenerative Disorders;Neurons;novel;optogenetics;Pathway interactions;Pattern;Physiological;Play;Positioning Attribute;presynaptic;Property;Public Health;rabies label;Recovery;Recovery of Function;Recovery Support;recruit;Rehabilitation therapy;Research;response;Role;Spinal Cord;Spinal cord damage;Spinal cord injury;Stroke;structural imaging;Synapses;synaptogenesis;Therapeutic;therapeutic development;Therapeutic Intervention;Time;Training;Traumatic Brain Injury;two-photon;United States National Institutes of Health

PROJECT_TITLE: The Role of Corticospinal Neurons in the Recovery of Dexterous Forelimb Function After Spinal Cord Injury


NIH_SPENDING_CATS: Digestive Diseases;Digestive Diseases - (Peptic Ulcer);Infectious Diseases

ORG_CITY: SANTA CRUZ

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: The proposed research is relevant to public health and specifically to NIH’s mission to seek fundamental knowledge about the behavior of living systems and apply that knowledge to enhance health and reduce the burden of disease. Our experiments will fill a gap in our understanding of basic Helicobacter pylori physiology and metabolism during colonization. This work will pave the way for new treatments that enhance antibiotic cure of H. pylori.

PI_NAMEs: OTTEMANN, KAREN M (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Address;Affect;Antibiotics;Bacteria;Bacterial Infections;Behavior;Binding;Biochemical;Biological Assay;burden of illness;Cancer Etiology;Cancerous;Cessation of life;Chemoreceptors;Chemotaxis;Citrates;Collaborations;colonization resistance;Complement;Crystallization;Crystallography;Cues;Data;Disease;experimental study;extracellular;Frequencies;Fumarates;Gastrointestinal tract structure;gene product;Genes;Genetic Transcription;Gland;Growth;Health;Helicobacter Infections;Helicobacter pylori;host-microbe interactions;Immune;in vivo;Incidence;Individual;Infection;innovation;insight;Knowledge;Ligand Binding;Ligand Binding Domain;Ligands;malignant stomach neoplasm;Measures;Mediating;Metabolic;Metabolism;Methods;Microbe;Mission;Molecular Biology;Molecular Conformation;mouse model;Mucous Membrane;Mus;mutant;Nature;new therapeutic target;novel therapeutics;Organism;Outcome;pathogen;Pathogenesis;Pathogenicity;Persons;Physiology;Play;Population;Population Control;Population Dynamics;pressure;prevent;Process;Proteins;Public Health;receptor;Regulon;Research;Resistance;Resolution;response;Role;Series;Shapes;Signal Transduction;Signaling Molecule;Stomach;Structural Biologist;Structure;Testing;Therapeutic;Tissues;Ulcer;United States;United States National Institutes of Health;Waste Products;Work

PROJECT_TITLE: The function of chemotactic signal transduction during colonization and disease


ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research aims to understand how tau pathology alters protein biogenesis in neuronal compartments. Thus, this proposal is relevant to the part of the NIH's mission that pertains to understanding the pathogenesis of Alzheimer's disease and related dementia and discovering molecular targets for therapeutic intervention.

PI_NAMEs: PARK, JOONGKYU  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Address;age related;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;Amyloid beta-Protein;amyloid pathology;Animals;Appearance;Axon;Biogenesis;Biological Assay;Biological Models;Biology;Brain;Brain Diseases;Brain region;Cells;cognitive function;Data;Dendrites;Dendritic Spines;dentate gyrus;Deposition;Etiology;Event;experimental study;extracellular;Foundations;Functional disorder;Funding Opportunities;Future;Hippocampus;Human;Impaired cognition;Impairment;in vivo;innovation;insight;Intervention;Knowledge;Link;link protein;Messenger RNA;meter;Methods;Mission;Modeling;Molecular;Molecular Target;molecular targeted therapies;Morphology;mouse model;mutant;Nerve Degeneration;Neurofibrillary Tangles;neuron loss;Neurons;novel;Pathogenesis;Pathogenicity;Pathologic;Pathology;Play;Positioning Attribute;postsynaptic;Predisposition;Presynaptic Terminals;Process;Protein Biosynthesis;Proteins;Proteomics;Research;response;Ribosomes;Role;Senile Plaques;Site;Solid;Structure;Symptoms;Synapses;synaptic function;Synaptic plasticity;tau Proteins;Tauopathies;Testing;Therapeutic Intervention;Time;tool;Translations;United States National Institutes of Health;Work

PROJECT_TITLE: Local protein synthesis in tau pathology neurodegeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Q (55)]


ORG_CITY: NEW YORK

ORG_NAME: NEW YORK GENOME CENTER

PHR: Project Narrative We propose to develop a set of statistical methods and analytical approaches for the developmental GTEx (dGTEx) project, with multi-modal and multi-tissue molecular data from pediatric post-mortem donors. We will develop new methods to analyze transcriptome and multi-omic variation to characterize molecular processes of organ development, and identify genetic regulatory variants in pediatric tissues. We foresee that the methods and analysis proposed in this project will empower biological discovery and uncover disease risk factors and mechanisms that originate or manifest during early life.

PI_NAMEs: BATTLE, ALEXIS ;GUIGO, RODERIC ;IM, HAE KYUNG ;LAPPALAINEN, TUULI  (contact);MELE, MARTA

PROJECT_TERMS: Address;Adolescence;Adoption;Adult;Age;Aging;Alternative Splicing;Automobile Driving;Autopsy;Biological;cell type;Characteristics;Childhood;Chronology;cohort;Collaborations;Communities;Complex;Computer software;Coupled;Data;Data Analyses;data complexity;data modalities;data resource;Data Set;data structure;deep learning;design;Development;Disease;disorder risk;diverse data;empowerment;epigenome;experience;functional genomics;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;Genetic;genome wide association study;genomic data;Genotype-Tissue Expression Project;Histology;Human;human data;human disease;human tissue;Image;improved;Information Dissemination;insight;inter-individual variation;Leadership;Life;life span;Maps;method development;Methods;Modality;Modeling;Molecular;multimodal data;multimodality;multiple omics;Noise;nonhuman primate;novel;organ growth;Phenotype;predictive modeling;primate development;Process;Productivity;Protein Isoforms;rare variant;recruit;Research Design;Resolution;Resources;Risk Factors;Role;Sample Size;Sampling;Statistical Methods;Statistical Models;Structure;Tissues;trait;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Variant;Work

PROJECT_TITLE: Statistical Methods for Characterizing Molecular Mechanisms of Human Tissue Development and Disease


NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE In humans, damage to motor cortex or its outputs causes profound and often permanent movement deficits. Treating dysfunction, or finding ways to bypass it using a brain-computer interface, requires a principled understanding of normal function. The goal of this proposal is to use novel experimental approaches to illuminate how neural activity in motor cortex subserves the generation and control of our movements.

PI_NAMEs: CHURCHLAND, MARK M (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TITLE: Determining the Sources of Motor-Cortex Response Complexity

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome;Pediatric

ORG_DEPT: BIOCHEMISTRY

PHR: PROJECT NARRATIVE The goal of this project is to identify fluoride export inhibitors for cariogenic microorganisms, determine their mechanism of action, and their effects on physiologically complex dental biofilms. Fluoride efflux inhibitors will potentiate the anticaries effect of fluoride in over-the-counter products like toothpastes and mouth rinses to combat early childhood caries.

PI_NAMEs: ANDALO-TENUTA, LIVIA MARIA;STOCKBRIDGE, RANDY B. (contact);ZAMAN, LUIS

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Acids;Advanced Development;Affect;Affinity;Aftercare;anticaries;antimicrobial;Antimicrobial Effect;Biochemical;Biodiversity;Biological;Biological Assay;Biophysics;Candida albicans;Carbohydrates;care costs;Cells;Chemicals;Child;Child Development;Chlorhexidine;Clinical;combat;Communities;Complex;Consumption;Coupled;cytotoxicity;Data;Data Set;Dental;dental biofilm;Dental caries;Dentistry;design;Diet;Dietary Sugars;Disease;Dose;drug development;dysbiosis;early childhood;Early treatment;Ecology;effective therapy;Electrophysiology (science);Evolution;experimental study;Exposure to;Family;family burden;Famines;Feeds;Financial Hardship;fitness;Fluoride Ion;Fluorides;fungus;Future;Goals;Growth;Health;Impairment;In Vitro;inhibitor;Lead;Libraries;Logic;Machine Learning;mathematical model;Membrane Proteins;Metabolic Pathway;Metabolism;metabolomics;Metagenomics;Methods;Microbe;microbial;Microbial Biofilms;microbial signature;microbiome;microorganism;Minerals;Modeling;Modernization;Molecular;Morbidity - disease rate;mortality;Mutagenesis;Natural Products;next generation;novel;nutrition;Oral;Oral cavity;oral microbiome;oral pathogen;oral streptococci;Pain;pathogen;Pathogenicity;Patients;personalized medicine;Physiological;Population;preclinical development;predicting response;Predisposition;Probability;Process;Productivity;Property;Proteins;Quality of life;Rattus;Research Personnel;Resistance;Saliva;Sampling;Schools;screening;side effect;small molecule;Source;Specialist;Specificity;Streptococcus;Streptococcus gordonii;Streptococcus mutans;Stress;structural biology;sugar;System;Testing;Therapeutic Effect;Tooth structure;Toothpaste;Toxic effect;trait;transcriptomics;Treatment Protocols

PROJECT_TITLE: A multiscale approach to develop and apply fluoride efflux inhibitors to reverse oral dysbiosis and eliminate early childhood caries

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 CC (14)]


NIH_SPENDING_CATS: Chronic Pain;Neurodegenerative;Neurosciences;Opioids;Pain Research;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Endogenous opioids protect against acute pain but fail to completely control chronic pain. Identifying how and where neuropathic injury alters these systems is critical for understanding the development and maintenance of chronic pain. The goal of this proposal is to better understand how and where endogenous opioid systems are disrupted in chronic pain to find new non-opioid mechanisms to control pain.

PI_NAMEs: AL-HASANI, REAM ;MCCALL, JORDAN G. (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Absence of pain sensation;Acute;Acute Pain;Analgesics;Anatomy;Animals;antinociception;Behavior;Biological Assay;Biological Psychiatry;Brain Stem;Calcium;Cells;Chronic;chronic pain;chronic pain management;conditional knockout;Data;Development;Disinhibition;Drug Delivery Systems;Efferent Pathways;endogenous opioids;G-Protein-Coupled Receptors;Gene Expression;Generations;Goals;Hyperalgesia;Hypersensitivity;Image;In Situ Hybridization;in vivo;injured;Injury;interdisciplinary approach;Ligands;locus ceruleus structure;Maintenance;Measures;mechanical allodynia;Mechanics;Medial;Mediating;Microdialysis;Modeling;mu opioid receptors;Mus;negative affect;nerve injury;neurochemistry;Neurons;Neuropathy;neuropsychiatric disorder;neurotransmitter release;Neurotransmitters;Nociception;non-opioid analgesic;noradrenergic;Opioid;Opioid Peptide;Opioid Receptor;optogenetics;Pain;Pain Disorder;pain inhibition;Pain management;pain processing;painful neuropathy;Prefrontal Cortex;prevent;Property;Prosencephalon;Published Comment;receptor;receptor expression;receptor function;Receptor Signaling;Regulation;Research;Role;Series;Signal Transduction;Site;spared nerve;Spinal Cord;Spinal cord posterior horn;Stress;System;Targeted Research;Testing;Therapeutic;therapeutic target;Thermal Hyperalgesias;trafficking;Translational Research;Work

PROJECT_TITLE: Endogenous opioid regulation of locus coeruleus-mediated analgesia

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: FOOD AND DRUG ADMINISTRATION

PHR: NARRATIVE The UCSF-Stanford Center of Excellence in Regulatory Sciences and Innovation (CERSI) conducts collaborative research in innovative regulatory science. This research enhances the FDA’s public health mission including the evaluation of safe and effective medical products. In addition, the CERSI develops training and outreach programs for the purpose of training students, postdoctoral fellows and career scientists in regulatory sciences.

PI_NAMEs: ALTMAN, RUSS BIAGIO;GIACOMINI, KATHLEEN M (contact)

PROGRAM_OFFICER_NAME: SEPULVEDA, KRISTIN

PROJECT_TITLE: UCSF-Stanford Center of Excellence in Regulatory Science and Innovation


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Nutrition;Pancreatic Cancer;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: PROJECT NARRATIVE Pancreatic ductal adenocarcinoma (PDAC) is in urgent need of therapeutic strategies that offer an improvement in clinical outcome and the targeting of glutamine metabolism represents a promising approach in developing anti-cancer therapies. We have identified that the stimulation of macropinocytosis, an amino acid supply route in cancer cells, represents a novel metabolic adaptation to glutamine mimicry and we aim to establish the biological framework for the development of new polytherapies for PDAC that are centered on the targeting of glutamine metabolism and macropinocytosis.

PI_NAMEs: COMMISSO, COSIMO  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Amiloride;Amino Acids;Anabolism;analog;asparaginase;Asparagine;Aspartate-Ammonia Ligase;Biological;Biological Models;Biosensor;cancer cell;cancer therapy;Cell Survival;Cells;Chlorides;Clinical;Clinical Trials;Combined Modality Therapy;Data;Dependence;Development;Effectiveness;Enzymes;experimental study;Extracellular Protein;fitness;Genetic;Glutaminase;Glutamine;Growth;Homeostasis;Human;improved;in vivo;inhibitor;innovation;insight;Ion Transport;Kidney;knock-down;Label;Link;Liquid substance;Lysine;Maintenance;Malignant neoplasm of pancreas;Malignant Neoplasms;Metabolic;Metabolism;mimetics;mimicry;Molecular;Monitor;mouse model;Neoplasm Metastasis;neoplastic cell;Norleucine;novel;Nutrient;Outcome;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pathway interactions;pharmacologic;Phase;Play;Primary Neoplasm;Prodrugs;Protein Deficiency;Protein Kinase;Proteins;ratiometric;response;Role;Route;Small Interfering RNA;Source;Stress;Testing;Therapeutic;tumor;tumor growth;uptake;Xenograft procedure

PROJECT_TITLE: Macropinocytosis Inhibition as a Glutamine Mimetic Sensitization Strategy in Pancreatic Cancer

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


ADMINISTERING_IC: DK

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity;Pediatric

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative Beige adipocytes have anti-obesity and anti-diabetes actions in mice and humans. We have defined new roles for developmentally hard-wired postnatal beige adipocytes, but their source, trajectory, and functions remain incompletely understood. Uncovering the origin and dynamics of postnatal beige adipocytes and establishing their functions in normal physiology and in obesity would provide fundamental new insights into a key cellular regulator of tissue homeostasis and whole-body metabolism that could be harnessed to develop new therapies for obesity, type 2 diabetes, and associated diseases.

PI_NAMEs: COHEN, PAUL  (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Ablation;Address;adipocyte differentiation;Adipocytes;Adipose tissue;Adrenergic beta-Agonists;Adult;Affect;Anti-diabetic Drugs;Appearance;bioinformatics tool;Biological Models;Brown Fat;cancer type;cardioprotection;Cardiovascular Diseases;Cell Physiology;cell type;Cells;Cellular biology;Chemicals;Chronic;clinical phenotype;conditioning;Coupled;Crowns;Data;Data Set;Development;Diabetes Mellitus;dietary;Disease;emerging adult;Endocrine;experimental study;Fatty acid glycerol esters;Fibrosis;Foundations;Functional disorder;Genetic Models;Homeostasis;Human;In Vitro;in vivo;Inflammation;insight;Insulin Resistance;interest;Knowledge;lipid biosynthesis;mature animal;Mediator;Metabolic;Metabolic Diseases;Metabolism;Modeling;Molecular;Molecular Profiling;Monitor;mouse model;Mus;nerve supply;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;novel therapeutics;Nuclear;Obesity;Obesity associated disease;obesity treatment;Outcome;Overnutrition;paracrine;Paracrine Communication;Physiology;postnatal;postnatal period;progenitor;programs;Property;Research;response;Risk Factors;Role;Shapes;Signal Transduction;Source;stem cells;Structure;Sympathetic Nervous System;Techniques;Testing;Therapeutic;Thermogenesis;Time;Tissues;transcriptomics;Transplantation;United States

PROJECT_TITLE: The Origin, Dynamics, and Function of Postnatal Beige Adipocytes

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ORG_CITY: Nashville

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative We propose a comprehensive bioengineering approach to develop a cell-based therapy to treat arthritis. By programming joint-resident cells to execute customized responses to cartilage matrix degradation, our approach instructs cells to constrain expression of therapeutic transgenes to an arthritic environment exhibiting a unique signature of disease. Our proposal investigates strategies for both ex vivo and in situ cell engineering, potentiating eventual clinical translation of this technology.

PI_NAMEs: BRUNGER, JONATHAN MATTHEW (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Antibodies;Arthritis;arthritis therapy;arthropathies;articular cartilage;Attenuated;Behavior;Biological;Biological Response Modifier Therapy;Bioluminescence;Biomedical Engineering;Cartilage;cartilage degradation;Cartilage Matrix;cartilage regeneration;cartilage repair;CD4 Positive T Lymphocytes;cell behavior;Cell Communication;Cell Physiology;Cell Therapy;cell type;Cells;cellular engineering;Chondrocytes;Chronic;Clinical;clinical translation;Collagen;Collagen Fiber;Collagen Type II;combat;CRISPR/Cas technology;Custom;cytokine;Data;Degenerative Disorder;Degenerative polyarthritis;delivery vehicle;design;Deterioration;Diagnostic;Disease;DNA delivery;drug production;Engineered Gene;Engineering;Environment;Enzymes;Exhibits;feature selection;Fibroblasts;Gene Delivery;Gene Expression;gene product;gene therapy;Genes;Goals;Health;Homeostasis;Human;immune cell infiltrate;In Situ;in vitro Model;in vivo;in vivo Model;Inflammation;Inflammatory;innovation;Investigation;joint destruction;joint function;joint inflammation;joint injury;Joints;Knee;Lesion;Licensing;Ligands;Limb structure;local drug delivery;Luciferases;Measures;mechanical load;Mechanics;Mediating;Mesenchymal Stem Cells;Modeling;Monoclonal Antibodies;Mus;Musculoskeletal;nanoparticle;notch protein;Operative Surgical Procedures;Outcome;Pathology;Patients;Performance;Pharmaceutical Preparations;Phenotype;plasmid DNA;Porosity;Procedures;programs;receptor;regeneration function;regenerative;Regenerative engineering;Regenerative Medicine;Regulation;Resolution;response;Signal Induction;Signal Transduction;Silicon;Site;Sleeping Beauty;Synovial Cell;Synovial Membrane;synthetic biology;System;T-Lymphocyte;Technology;Testing;theranostics;Therapeutic;therapeutic transgene;Time;Tissues;tool;transgene expression;Transgenes;Transplantation;Transposase;Traumatic Arthropathy;Work;years of life lost to disability

PROJECT_TITLE: Engineered cells as agents of arthritis therapy governed by artificial signaling

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Prevention;Women's Health Research

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: PROJECT NARRATIVE This research will evaluate the effectiveness and implementation of a couples shared decision-making intervention, CUPID (Couples United in HIV Prevention Informed Decisions), delivered in community and clinic settings to support women’s pre-exposure prophylaxis (PrEP) choice and use through male partner support and shared decision-making. Through a partnership with a large demonstration project in Uganda that offers choice in biomedical HIV prevention to women, we will evaluate whether CUPID is effective in increasing PrEP uptake, persistence, and use among Ugandan women and assess implementation outcomes to determine whether it is acceptable and feasible to implement. If successful, CUPID will offer a community-based strategy for engaging male partners to support PrEP choice and improve HIV prevention among women and provide a scalable and sustainable intervention that will contribute to a more comprehensive approach to HIV prevention.

PI_NAMEs: AKELLO, CAROLYNE ;MINNIS, ALEXANDRA M (contact);MIREMBE, BRENDA GATI

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adopted;Adoption;Africa South of the Sahara;Agency for International Development;AIDS prevention;Behavioral;Clinic;Clinical;Clinical Trials;cohort;Collaborations;Communication;Communities;community advisory board;Consolidated Framework for Implementation Research;Country;Couples;Dapivirine;Data;Data Sources;Decision Making;design;Educational workshop;Effectiveness;effectiveness evaluation;effectiveness/implementation study;Ensure;experience;Female Adolescents;female sex worker;Focus Groups;Future;Geographic Locations;Goals;Health;Health care facility;Heterosexuals;HIV;Hybrids;implementation evaluation;implementation framework;implementation outcomes;implementation research;improved;Injectable;Interruption;Intervention;intervention refinement;Interview;Joints;life span;male;men;Men's Role;Methods;Oral;Outcome;Paper;peer;Play;Population;Positioning Attribute;pre-exposure prophylaxis;preference;pregnancy prevention;Prevention;process evaluation;prospective;provider intervention;Public Health;Questionnaires;Randomized;Research;Research Design;scale up;Series;service utilization;shared decision making;Testing;theories;therapy design;Time;tool;Uganda;United States;Update;uptake;Vaginal Ring;Woman;women's prevention;young woman;Zimbabwe

PROJECT_TITLE: Improving Choice and Use of Biomedical HIV Prevention for Women in Uganda: A Couples-Based Approach


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Stroke

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: The objective of this project is to develop an easily accessible MRI-based cerebral metabolic rate of oxygen consumption (CMRO2) mapping for evaluating ischemic lesion viability in acute stroke patients, which will enable vital cerebral oxygen metabolic imaging in clinical decision-making for managing patients with acute ischemic stroke and advanced atherosclerotic diseases.

PI_NAMEs: GUPTA, AJAY ;KAMEL, HOOMAN ;WANG, YI  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Accounting;Acute;acute care;acute stroke;Agreement;arterial spin labeling;Atherosclerosis;Biophysical Process;Blood capillaries;blood oxygen level dependent;Blood Vessels;Brain;brain magnetic resonance imaging;brain tissue;Cerebrovascular Circulation;Cerebrum;Chronic;Clinical;clinical decision-making;Complex;Data;deep neural network;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;follow-up;Functional disorder;gray matter;Half-Life;Health;Hemorrhage;improved;Infarction;Iron;Ischemia;ischemic lesion;Ischemic Stroke;Left;Magnetic Resonance Imaging;Maps;Measurement;Measures;metabolic imaging;metabolic rate;Methods;Modeling;Monte Carlo Method;multi-scale modeling;Myelin;Nervous System Disorder;Neurological outcome;novel;Outcome;Oxidative Phosphorylation;Oxygen;Oxygen Consumption;Patient Care;Patients;Perfusion;perfusion imaging;personalized care;Phase;Positron-Emission Tomography;post stroke;Predisposition;Process;radiochemical;Radiochemistry;radioligand;radiotracer;Randomized;recruit;Reference Standards;Reperfusion Therapy;Risk;Scanning;Signal Transduction;Site;Stroke;stroke patient;stroke symptom;Surrogate Markers;Testing;Therapeutic;Time;Tissue Viability;Tissues;tool;Training;Triage;United States National Institutes of Health;Veins;white matter

PROJECT_TITLE: Quantitative Cerebral Oxygen Metabolic Imaging of Acute Ischemic Stroke

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PI_NAMEs: GALLI, STEPHEN JOSEPH (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Neurosciences

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Narrative The proposed studies will evaluate the role of neural inflammation/oxidative stress in regulating the neural activity to the heart. Specific therapy to activate a protein called Nrf2 will be carried out in order to reduce rhythm disorders in the setting of chronic heart failure.

PI_NAMEs: WANG, HANJUN  (contact);ZUCKER, IRVING H

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Accounting;Action Potentials;Adrenergic beta-Antagonists;Angiotensin II Receptor;Angiotensin-Converting Enzyme Inhibitors;Animals;Anti-Arrhythmia Agents;Anti-Inflammatory Agents;antioxidant enzyme;Antioxidants;Area;Arrhythmia;Attenuated;Axon;Binding;Brain;Cardiac;Cardiovascular Diseases;catalase;Cell Nucleus;Cells;Chest;Clinical;Code;Complex;Congestive Heart Failure;Curcumin;cytokine;Cytoplasm;Cytosol;Data;Developed Countries;Diagnosis;Disease;Disease Progression;Electrophysiology (science);Encapsulated;Enzymes;Epidemic;Foundations;Free Radicals;Functional disorder;ganglion cell;Ganglionectomy;Generations;Genes;Genetic;glutathione peroxidase;Heart;Heart Atrium;Heart failure;heart function;heme oxygenase-1;high risk;Homeostasis;Hydrogels;Hypertension;Impairment;improved;Incidence;Increased sweating;Infiltration;Inflammation;Inflammatory;knock-down;Laboratories;Life;Link;Long QT Syndrome;LoxP-flanked allele;Macrophage;Measures;Mediating;Mediator;Medical center;Micelles;Mitochondria;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Myocardial Infarction;Nature;Nerve;neural;neuroinflammation;neuronal excitability;Neurons;novel;novel therapeutics;NQO1 gene;nuclear factor-erythroid 2;Nuclear Translocation;overexpression;oxidant stress;Oxidation-Reduction;Oxidative Stress;Pathogenesis;Patients;Peripheral;pharmacologic;Pharmacy (field);Physiological;Procedures;Proteins;Rattus;Research;response;Response Elements;restoration;Role;Signal Transduction;Solid;Source;structural heart disease;Structure;Structure of stellate ganglion;Sudden Death;Sulforaphane;Sympathectomy;Sympathetic Ocular-Ophthalmoplegia;System;Techniques;Time;Tissues;transcription factor;Transfection;Transgenic Mice;ubiquitin-protein ligase;Ventricular Arrhythmia;Ventricular Tachycardia;Viral

PROJECT_TITLE: Stellate Ganglia Nrf2 Signaling and Enhanced Cardiac Sympathetic Tone in Chronic Heart Failure

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]