ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Biotechnology;Nanotechnology;Osteoarthritis;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative  Meniscus tears are the most common injuries of the knee, and can lead to osteoarthritis in both young and aged populations. By taking advantage of multiple animal models, this project will investigate a novel signaling mechanism in meniscus metabolism and design an innovative drug delivery therapy to treat meniscus injury and thereby prevent osteoarthritis progression. Information garnered from these studies will be important for advancing our knowledge of joint biology and designing novel therapeutic strategies for meniscus repair.

PI_NAMEs: MAUCK, ROBERT L;QIN, LING  (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Ablation;absorption;Acceleration;Adult;Affect;Aftercare;Age;Aging;aging population;Animal Model;Anterior;Antibodies;Attenuated;Biological;Biology;Cartilage;Cell Lineage;Cell Physiology;Cells;Chemistry;Clinical Treatment;Data;Degenerative polyarthritis;design;Development;Disease;Dose;Drug Delivery Systems;Erinaceidae;Excision;fabrication;Family suidae;Femur;Fibrocartilages;gain of function;Goals;healing;Health;Heterogeneity;Homeostasis;Horns;Human;improved;in vivo;Injury;innovation;Intra-Articular Injections;Joints;Knee;Knee Injuries;Knee Osteoarthritis;Knowledge;Label;loss of function;Lubricants;Lubrication;Maintenance;Mechanics;Mediating;meniscal tear;meniscus injury;Meniscus structure of joint;Mesenchymal Stem Cells;Metabolism;migration;Miniature Swine;Modeling;mouse model;multidisciplinary;Mus;nanoparticle;nanoparticle delivery;Nanotechnology;Natural regeneration;novel;novel therapeutic intervention;novel therapeutics;old mice;Older Population;Oligonucleotides;Operative Surgical Procedures;Organ;Pain management;palliative;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;Pharmacotherapy;Play;preservation;prevent;Procedures;Process;progenitor;Proliferating;purmorphamine;recruit;repair function;repaired;Reporter;response;response to injury;Role;scaffold;Shock;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;smoothened signaling pathway;spatiotemporal;stem;stem cell migration;stem cells;Structure;Surgical Management;Surgical sutures;System;systemic barrier;Testing;Therapeutic;therapeutic target;Thick;tibia;Tissues;tool;Translating;Work

PROJECT_TITLE: Activation of endogenous progenitors via a nanoparticle-conjugated fibrous system to enhance meniscus repair

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Cardiovascular;Emerging Infectious Diseases;Genetics;Heart Disease;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Enteroviruses are a major source for disease and hospitalization, but currently little is known about their mechanism of infection and there is no available treatment. Using recent advances in single-cell transcriptomics and ultra-deep virus population sequencing, we will explore the dynamics of in vivo enterovirus infection and the host response to it across cells and tissues. Combining these strategies with animal models defective in specific antiviral pathways, we will gain mechanistic insights into viral spread and pathogenesis, which is critical to develop effective antiviral drugs and vaccines.

PI_NAMEs: ANDINO, RAUL  (contact);SIGAL, LUIS J

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Acute;Adolescent;Affect;Alleles;Animal Model;Anti-viral Agents;Anti-viral Response;Atlases;Attenuated;Biological;Brain Stem;Cardiomyopathies;cell type;Cells;Clinical;Coxsackie B Viruses;CRISPR/Cas technology;Data;Data Set;deep learning;deep sequencing;Development;Diabetes Mellitus;Disease;emerging pathogen;Encephalitis;Enterovirus;Enterovirus 68;Enterovirus 71;Enterovirus Infections;Evolution;experimental study;Family;Genes;Genetic Determinism;Genetic Structures;Genetic Transcription;Genomics;Goals;Hand, Foot and Mouth Disease;Heart Diseases;Hospitalization;Human;Human poliovirus;Immune response;in vivo;Individual;Infant;Infection;Innate Immune Response;innovative technologies;insight;Interferon alpha;Interferon Type I;Interferon-beta;Interferons;Intervention;Invaded;Knowledge;Lesion;Life;Link;Maps;mathematical model;Measures;Medical;Meningitis;Methods;mouse model;Mus;mutant;Mutation;Myocarditis;Natural Immunity;neonatal sepsis;Nerve Tissue;Neurologic Symptoms;novel;pan-enterovirus;Pancreatitis;Paralysed;Pathogenesis;Pathogenicity;Pathway interactions;Pericarditis;Pharmaceutical Preparations;Phylogenetic Analysis;Population;Population Dynamics;Population Genetics;pressure;prevent;Process;respiratory;Respiratory Signs and Symptoms;response;Reverse engineering;Role;Severities;Shapes;Signal Transduction;single cell analysis;single-cell RNA sequencing;Source;spatiotemporal;Specificity;Structure;Testing;tissue tropism;Tissue-Specific Gene Expression;Tissues;transcriptome;transcriptomics;Tropism;United States;vaccine development;Vaccines;Viral;Virulence;Virus;Virus Diseases;virus genetics;virus host interaction;Virus Replication

PROJECT_TITLE: Mapping spatiotemporal dynamics during enterovirus infection across cells and tissues


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Genetics;Infertility;Maternal Health;Pediatric;Pregnancy;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Defects in implantation are a major cause of early pregnancy loss, can underlie serious pregnancy complications, and predispose the development of disease after birth. A lack of understanding regarding the mechanisms regulating the embryo implantation and the establishment of pregnancy represents a major barrier toward the discovery of new diagnostic tools and therapeutic intervention. The goal of this proposed project is to investigate the mechanisms by which local glucocorticoid signaling regulates the establishment and maintenance of pregnancy.

PI_NAMEs: WHIRLEDGE, SHANNON D (contact)

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: Area;Biological Assay;Biological Response Modifiers;Birth;Cell Differentiation Inhibition;Cell Physiology;Cells;chemokine;comparison control;Complication;Critical Pathways;cytokine;Cytokine Signaling;Cytometry;Dangerousness;Data;Decidual Cell;Decidual Cell Reactions;Defect;Development;diagnostic biomarker;diagnostic tool;Disease;early pregnancy;early pregnancy loss;Embryo;Endometrial;Endometrium;Environment;Etiology;Event;failure Implantation;Family;Fertilization;Fetal Growth Retardation;Fetus;Functional disorder;Gene Expression;Gene Expression Regulation;Genes;Genetic Polymorphism;Genetic Transcription;Glucocorticoid Receptor;Glucocorticoids;Goals;Growth;Habitual Abortion;healthy pregnancy;Human;Image;Immune;Immune response;Immune system;Immune System Diseases;immunoregulation;Impairment;implantation;improved;Incidence;Inflammatory;Inflammatory Response;innovation;Investigation;knock-down;Knockout Mice;Link;Macrophage;Mass Spectrum Analysis;maternal immune system;Molecular;mouse model;Movement;Mus;National Institute of Child Health and Human Development;natural Blastocyst Implantation;neutrophil;novel diagnostics;novel therapeutic intervention;Pathogenesis;Pathway interactions;Phenotype;Population;Pre-Eclampsia;Pregnancy;Pregnancy Complications;Pregnancy loss;Pregnancy Maintenance;Pregnancy Outcome;Pregnancy Rate;Process;Production;pup;Race;racial population;Receptor Signaling;Recurrence;Regulatory T-Lymphocyte;Reproduction;Reproductive Medicine;Research;Resistance;response;side effect;Signal Pathway;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;Spontaneous abortion;Stromal Cells;Testing;Therapeutic Intervention;therapeutic target;Time;Tissues;trafficking;Transfection;trying to conceive;Uterus;Woman;Work

PROJECT_TITLE: Uterine Glucocorticoid Signaling: a Critical Pathway in the Establishment of Pregnancy

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: Aurora

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Narrative: We are developing a drug to modulate CD40-mediated inflammation in type 1 diabetes. Modulation of CD40 on beta cells, and on lymphocytes will protect from diabetes advancement. This grant will determine mechanism of action of a peptide that targets CD40 and its role during diabetes development.

PI_NAMEs: WAGNER, DAVID H. (contact)

PROGRAM_OFFICER_NAME: AKOLKAR, BEENA

PROJECT_TERMS: Adverse event;Antigen-Presenting Cells;Applications Grants;arm;Autoimmune Diseases;autoimmune inflammation;B-Lymphocytes;Beta Cell;Binding;Blood Glucose;Blood Platelets;C-Peptide;cell injury;Cell surface;Cells;Clinical;Clinical Treatment;Clinical Trials;Complete Blood Count;cytokine;Data;Dendritic Cells;design;Development;diabetes control;Diabetes Mellitus;diabetic;Diabetic mouse;Dose;drug action;Drug Kinetics;Drug usage;Effector Cell;Family;first-in-human;Fructosamine;Future;glycation;glycemic control;Glycosylated hemoglobin A;Goals;Grant;Human;human study;human subject;Hyperglycemia;Immune;Immunosuppression;improved;Inbred NOD Mice;Inflammasome;Inflammation;Inflammatory;innovation;Insulin;Insulin-Dependent Diabetes Mellitus;Invaded;Investigational New Drug Application;islet;Islet Cell;Islets of Langerhans;Islets of Langerhans Transplantation;Kidney Function Tests;Letters;Liver;Liver Function Tests;Lymphocyte;Lymphocyte Count;Macrophage;Maintenance;Measures;Mediating;member;Monoclonal Antibodies;Mus;novel strategies;Pathogenesis;Pathogenicity;Pathway interactions;peptide drug;Peptides;peripheral blood;Peripheral Blood Lymphocyte;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Phase;Phase Ia/Ib Clinical Trial;Placebos;Play;preclinical study;prevent;primary outcome;Production;receptor;restoration;Role;Safety;Series;Signal Transduction;small molecule;success;systemic inflammatory response;T-Cell Activation;T-Lymphocyte;therapeutic target;Time;TNF gene;TNFRSF5 gene;TNFSF5 gene;Toxicology;Transplantation;Tumor Necrosis Factor Receptor;Work

PROJECT_TITLE: Discovering the Mechanism of Action of a peptide drug, OPT101, that targets CD40 mediated inflammation in type 1 diabetes

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: STONY BROOK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: We our applying our new approach to control the cellular composition of specialized fats called membrane lipids within the membrane shell that surrounds cells to understand how membrane lipids and proteins are organized to control membrane function. Studies concentrate on membrane protein receptors (including insulin receptor) that control the response of cells to their environment, and on viruses for which controlling lipids may alter their ability to enter cells and their immunogenicity. The studies may lead to new methods to control membrane protein function to ameliorate disease and optimize vaccines.

PI_NAMEs: LONDON, ERWIN  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Antibodies;Biological Assay;Cell membrane;Cells;Cholesterol;Cyclodextrins;design;Disease;Environment;Erythrocytes;Fatty acid glycerol esters;Grant;GTP-Binding Proteins;Immune;immunogenicity;improved;In Situ;Insulin Receptor;lipid structure;Lipids;Liquid substance;Mammalian Cell;Membrane;Membrane Lipids;Membrane Proteins;Metabolic;Methods;Modeling;monolayer;Mutation;novel;novel strategies;Phospholipids;Physiological;Preparation;protein function;receptor;receptor function;response;SARS-CoV-2 spike protein;segregation;Signal Transduction;Sphingolipids;Sterols;Structure;Testing;Thick;Unsaturated Fats;uptake;Vaccines;Vesicle;Vesicular stomatitis Indiana virus;Viral;Virus

PROJECT_TITLE: TRANSFORMATIVE LIPID EXCHANGE APPROACHES TO STUDY MEMBRANE ORGANIZATION

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Clinical Research;Lung;Women's Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Narrative Asthma and allergic diseases are increasing in developed countries, and as adults, women have more asthma compared to men. IL-33 and its receptor, ST2, increase airway inflammation in patients with asthma, and our preliminary data suggest that testosterone and androgen receptor signaling decrease IL-33 release and allergic airway inflammation while increasing suppressive function of T regulatory cells. Findings from this proposal will provide the foundational research necessary to develop future asthma therapeutics for women and men with asthma and potentially other diseases with increased IL-33.

PI_NAMEs: NEWCOMB, DAWN C (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: Adult;Affinity;airway epithelium;airway hyperresponsiveness;airway inflammation;Alkanesulfonates;Allergens;Allergic;allergic airway inflammation;Allergic Disease;Alternaria;Androgen Receptor;Androgens;Apoptosis;Asthma;asthma model;asthmatic;asthmatic patient;Atopic Dermatitis;Attenuated;Binding;Biological Response Modifier Therapy;bronchial epithelium;CASP3 gene;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell Physiology;Cell Proliferation;cell type;Cells;Chromatin;Chronic Obstructive Pulmonary Disease;chronic rhinosinusitis;Clinical Research;clinically relevant;Data;dehydroepiandrosterone;Developed Countries;Development;Disease;Epithelial Cells;Female;FOXP3 gene;Funding;Future;Genes;Genetic Transcription;genome wide association study;Health Care Costs;Healthcare;Hormonal;Human;IL17 gene;Immune;Interleukin-10;Interleukin-13;Interleukin-4;Interleukin-5;Length;Lung;Lymph Node Tissue;lymph nodes;Lymphoid Cell;male;Maps;Mediating;men;Modification;Morbidity - disease rate;mouse model;Mucous body substance;Mus;Nasal Polyps;novel;novel therapeutics;Nuclear;Orchiectomy;Ovarian hormone;Pathway interactions;patient population;Patients;Peripheral Blood Mononuclear Cell;personalized medicine;posttranscriptional;preservation;Prevalence;Production;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;receptor;Receptor Signaling;Regulatory T-Lymphocyte;Reporter;Research;restraint;Signal Transduction;Supplementation;Symptoms;Testing;Testosterone;Th2 Cells;Therapeutic;transcription factor;Transforming Growth Factor beta;Woman

PROJECT_TITLE: Androgens inhibit IL-33 production and airway inflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(57)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Anxiety Disorders;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Narrative World Trade Center (WTC) responders were exposed to a mix of tiny dust particles as they participated in rescue and recovery efforts at the WTC in the aftermath of 9/11/2001, and a large number may have developed cognitive impairment, a symptom consistent with some neurodegenerative diseases. Given the magnitude and scale of events surrounding 9/11 and the level of exposure within a young civilian population, prior studies are insufficient to identify the etiology of neurocognitive and neuromotor symptoms evident among responders with PTSD. The proposed study will examine Beta-Amyloid and Tau burden using positron emission tomography (PET) combined with magnetic resonance neuroimaging (MRI) on a subset of individuals recruited as part of an existing NIA- funded study of cognitive aging to measure in order to determine whether there is evidence of Alzheimer’s disease in the brains of WTC responders with symptoms consistent with Alzheimer’s disease.

PI_NAMEs: CLOUSTON, SEAN  (contact);KUAN, PEI-FEN ;VASKA, PAUL

PROGRAM_OFFICER_NAME: KWOK, RICHARD K

PROJECT_TERMS: Age;age difference;aged;Aging;aging related;Alzheimer's Disease;Alzheimer's disease related dementia;American;Amyloid;Amyloid beta-Protein;Amyloid deposition;Biological Markers;Blood;blood-based biomarker;Brain;Brain imaging;Case/Control Studies;Chronic Post Traumatic Stress Disorder;Clinical;Clinical Trials;Cognitive;Cognitive aging;cognitive testing;cohort;critical period;Data;Deposition;Diagnosis;Disease;disease classification;Dust;Early Onset Alzheimer Disease;Education;entorhinal cortex;Ethnic Origin;Etiology;Event;expectation;experience;Exposure to;Feasibility Studies;follow-up;Funding;Health;imaging biomarker;Impaired cognition;improved;in vivo;Incidence;Individual;Inflammatory;Life;Ligands;Light;Link;longitudinal positron emission tomography;Magnetic Resonance;Magnetic Resonance Imaging;Measures;Medical;men;middle age;mild cognitive impairment;Minority;molecular imaging;Monitor;National Institute on Alcohol Abuse and Alcoholism;Nature;Nerve Degeneration;Neurobehavioral Manifestations;Neurocognitive;Neurodegenerative Disorders;neurofilament;neuroimaging;neuroinflammation;neuropathology;Occupations;Olfactory Cortex;operation;particle;Pathogenesis;Patients;Pattern;Peripheral;Physical Function;physically handicapped;Pituitary Gland;Plasma;Population;Positron-Emission Tomography;Post-Traumatic Stress Disorders;Prognosis;programs;Proliferating;Prospective Studies;Proteins;Proteomics;Protocols documentation;Quality of life;Race;Recording of previous events;Recovery;recruit;Research;response;Sampling;Severities;sex;Site;Staging;Stressful Event;stressor;structural imaging;symptomatology;Symptoms;tau Proteins;Tauopathies;Temporal Lobe;Thick;Trauma;treatment response;Visit;Woman;World Trade Center exposure

PROJECT_TITLE: Burden and change in Alzheimers disease neuropathology in aging World Trade Center responders


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Clinical Research;Disability Research;Hearing Loss;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rehabilitation

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Speech-language disorders occur in 40% of very preterm infants, while 10% have permanent hearing loss. Neonatal hearing screening and cochlear implantation within the first few months have demonstrated the extreme plasticity of the developing infant brain, but speech-language disorders are typically not detected or treated before 3 years of age. The goal of this study is to use advanced measures of brain connectivity, sensitized hearing assessment, and speech evoked EEG at birth to predict infants at risk for speech-language disorders so they can start receiving intervention within the critical first year.

PI_NAMEs: HUNTER, LISA LEIGH (contact);VANNEST, JENNIFER J.

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: 3 year old;Age;Auditory;Auditory area;Auditory Evoked Potentials;Biological Markers;biomarker identification;Birth;Brain;Child;Cochlear implant procedure;Communication difficulty;Demographic Factors;Detection;Development;Diffuse;Diffusion Magnetic Resonance Imaging;Early identification;Early Intervention;Electroencephalography;Enrollment;extreme prematurity;Functional Magnetic Resonance Imaging;Funding;Gestational Age;Goals;Hearing;hearing impairment;Hearing problem;hearing screening;Hearing Tests;high risk;high risk infant;High-Frequency Hearing Loss;Impairment;improved;Infant;innovation;Intervention;Language;Language Disorders;language outcome;Language Therapy;Life;literacy;Longitudinal cohort;Magnetic Resonance Imaging;Measures;Methods;Modeling;National Institute of Neurological Disorders and Stroke;Neonatal;neurodevelopment;Neurodevelopmental Disorder;Neuronal Plasticity;Newborn Infant;novel;Nursery Schools;otoacoustic emission;Outcome;Outcome Measure;Perinatal;permanent hearing loss;Physiological;predictive modeling;Premature Birth;Premature Infant;Prevalence;Prognostic Marker;Prospective Studies;response;Rest;Risk;Risk Factors;Sampling;Scanning;School-Age Population;screening;Services;Speech;Speech Disorders;speech processing;Stimulus;study population;Survivors;Therapeutic Studies;white matter

PROJECT_TITLE: Earliest predictors of language outcomes in high-risk infants

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ORG_DEPT: PHARMACOLOGY

ORG_STATE: PA

PHR: This project will produce mouse models to study two blood proteins called MASP3 and MASP2 which are part of the body’s natural immune system but could also participate in certain autoimmune and inflammatory diseases such as arthritis and kidney disease. The proposed studies will use mouse models in which these two proteins are experimentally eliminated so that their deficiency can be evaluated to see if their absence will make a difference in arthritis and kidney disease. We will also develop antibodies to these proteins and test such antibodies as drug prototypes to see if they will be effective in treating arthritis and kidney disease. These studies may lead to the development of novel therapeutics for unmet medical need in the area of inflammatory and autoimmune conditions.

PI_NAMEs: SONG, WENCHAO  (contact)

PROGRAM_OFFICER_NAME: LEITNER, WOLFGANG W

PROJECT_TERMS: adaptive immunity;Alternative Complement Pathway;alternative pathway complement C3 convertase;Antibodies;Area;Arthritis;Autoimmune Diseases;Autologous;Binding;Blood Proteins;Body part;Cell surface;Clinical;Clinical Data;Collagen;Collectins;Complement;Complement Activation;Complement Factor B;Complement Factor D;complement pathway;Complex;Consumption;Data;defense response;Development;Disease;disease model;enzyme pathway;Enzymes;ficolin;Goals;group-specific protease;Hemolytic-Uremic Syndrome;Host Defense;IGA Glomerulonephritis;Immune system;in vivo;Inflammatory;Innate Immune System;Kidney Diseases;Knockout Mice;Knowledge;Lectin;Link;Mannose Binding Lectin;mannose-binding protein-associated serine proteases;MASP2 gene;Mediating;Medical;Microbe;microbial;Monoclonal Antibodies;mouse model;novel therapeutics;Pathogenesis;Pathology;Pathway interactions;Pattern Recognition;Pharmaceutical Preparations;Plasma;Play;pre-clinical;Process;Protein C Inhibitor;Proteins;prototype;Reaction;Regulation;Role;Serine Protease;Serine Proteinase Inhibitors;sugar;Testing;theories;Therapeutic;therapeutic target;tissue injury;Tissues

PROJECT_TITLE: MASPs as therapeutic targets in complement-mediated diseases

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Genetics;Heart Disease;Pediatric;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW YORK

ORG_DEPT: PHYSIOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE PI: Manu Ben-Johny, PhD Increased late Na current is a common pathophysiological mechanism for many cardiac ailments including congenital long QT syndrome and heart failure. In this collaborative project, we dissect the physiological role and molecular mechanisms of cardiac Na channel modulation by fibroblast growth factor homologous factors (FHF) in inhibiting late Na current in cultured adult ventricular myocytes and in induced pluripotent stem cell derived cardiomyocytes. We leverage in depth mechanisms to develop a novel peptide inhibitor of late Na current.

PI_NAMEs: JOHNY, MANU BEN (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Action Potentials;Adult;Alternative Splicing;Amino Acids;Arrhythmia;Binding Sites;Biological Assay;Biophysics;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cells;Clinical;clinically relevant;Closure by clamp;Data;Disease;Dizziness;Doctor of Philosophy;effectiveness evaluation;Engineering;Etiology;Exhibits;Fibroblast Growth Factor;Fibroblasts;fluorescence imaging;Fluorescence Resonance Energy Transfer;Functional disorder;Future;Heart;Heart Diseases;Heart failure;heart function;Homeostasis;Human;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;inhibitor;insight;Kinetics;Life;Link;Long QT Syndrome;Maps;Measurement;Molecular;Morphology;Muscle Cells;Mutagenesis;Mutation;Names;novel;Optics;Pathogenicity;Pathology;patient derived induced pluripotent stem cells;Penetration;Peptides;Pharmacology;Phase;Phenotype;Phosphorylation;Physiological;Physiology;Post-Translational Protein Processing;preservation;prevent;protective factors;Protein Isoforms;Proteins;Regulation;RNA Splicing;Rodent;Role;Scheme;Specificity;stem;Syndrome;System;Therapeutic;Transgenic Mice;Variant;Ventricular;Viral;voltage

PROJECT_TITLE: Mechanism-inspired Strategies to Prevent Pathogenic Late Na Current in Cardiac Arrhythmias

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE: Macrophages represent an understudied component of the blood stem cell niche. The studies proposed in this grant application will define bone marrow resident macrophages, and investigate how they regulate stem cell mobilization and regeneration. The proposed work has important implications for the treatment of blood disorders.

PI_NAMEs: STEIDL, ULRICH  (contact);WILL, BRITTA

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Animals;Applications Grants;blood treatment;Blood Vessels;Bone Marrow;CD47 gene;Cell Communication;Cell Maintenance;Cells;Cellular Structures;Collaborations;Connexin 43;Connexins;CRISPR/Cas technology;CSF3 gene;Data;Development;Embryo;Erythroblasts;Erythrocytes;Erythroid;erythroid differentiation;experimental study;Funding;Generations;Genes;Genetic;Genetic Models;genotoxicity;GJB3 gene;gut microbiota;Hematological Disease;Hematopoietic;hematopoietic stem cell differentiation;Hematopoietic Stem Cell heterogeneity;Hematopoietic Stem Cell Mobilization;hematopoietic stem cell niche;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Image;Immunofluorescence Immunologic;In Transferrin;Iron;Island;Laboratories;Light;Liver X Receptor;Macrophage;Mediating;metal transporting protein 1;Methods;microbiota;Molecular;Mus;Myelogenous;National Heart, Lung, and Blood Institute;Natural regeneration;novel;novel therapeutic intervention;Pathway interactions;Phagocytes;Population;Process;Production;progenitor;regeneration function;Regulation;residence;Role;senescence;Series;Signal Transduction;Singapore;spatial relationship;stem cell function;Stem Cell Mobilization;stem cells;Stromal Cell-Derived Factor 1;Stromal Cells;Structure;Synapses;TFRC gene;transcriptome sequencing;Universities;Work

PROJECT_TITLE: Contribution of macrophages in the HSC niche

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-C(02)M]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: GENETICS

ORG_NAME: STANFORD UNIVERSITY

PHR: The nerves that sense light in the eye, the photoreceptors, and the cells of the retinal pigment epithelium (RPE) form a critical partnership necessary for vision. We want to understand how the RPE’s response to reduced output from its powerplants, termed mitochondria, causes adverse effects on the adjacent photoreceptors. Success of this project may provide insight into the causes of age-related macular degeneration and could suggest new avenues for therapy development.

PI_NAMEs: VOLLRATH, DOUGLAS E. (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Ablation;Adverse effects;Affect;Age;Age related macular degeneration;Atrophic;autocrine;biological adaptation to stress;Cell Culture Techniques;cell motility;cell type;Cessation of life;Chronic stress;Complement;Coupling;Culture Media;Data;Defect;Distress;Electron Transport;Epithelium;Eye;FGF21 gene;fibroblast growth factor 21;Foundations;Genes;Genetic Transcription;Homeostasis;human disease;Hypertrophy;improved;Individual;Inherited;inhibitor;insight;Knock-out;Light;Link;Lipids;Mediator;Metabolic;Metabolism;mimetics;Mitochondria;mitochondrial dysfunction;Molecular;mouse model;mTOR Inhibitor;Mus;Nerve;Neural Retina;Ocular Pathology;Output;Oxidative Phosphorylation;paracrine;Pathology;Peptides;Personal Satisfaction;Phenotype;Photoreceptors;postnatal;Power Plants;Protein Secretion;receptor;Residual state;response;Retina;Retinal Diseases;Role;Signal Pathway;Signal Transduction;Sirolimus;Site;Stress;stressor;Structure;Structure of retinal pigment epithelium;success;Testing;therapy development;Time;Tissues;transcriptome;transcriptomics;Up-Regulation;Vision

PROJECT_TITLE: FGF21 as a mediator of RPE mitochondrial dysfunction

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_DEPT: UROLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Narrative About 10% of prostate cancers have mutations in the SPOP gene – roughly 20,000 men will be diagnosed with SPOP mutant prostate cancer in the US each year. These cancers show distinct molecular features, and activation of specific signaling pathways. Successful completion of this project will provide insights into the biology underlying this subclass of prostate cancer, define the ability to specifically target these cancers, and identify novel diagnostic and therapeutic approaches across prostate cancer classes.

PI_NAMEs: BARBIERI, CHRISTOPHER E (contact)

PROGRAM_OFFICER_NAME: HILDESHEIM, JEFFREY

PROJECT_TERMS: Address;Affect;Androgen Receptor;Androgens;Area;Automobile Driving;Biological;Biological Models;Biology;cancer invasiveness;cancer subtypes;Cell Culture Techniques;Clinical;Clinical Course of Disease;clinical investigation;Clinical Trials;clinically relevant;cohort;Data;Development;Diagnosis;Disease;DNA Sequence Alteration;Event;Feedback;Foundations;FRAP1 gene;Genes;Genetic;Genetic Transcription;Genetically Engineered Mouse;Genomics;Heterogeneity;Hormonal;Human;human disease;human model;In Vitro;in vitro Model;in vivo;in vivo Model;insight;Insulin-Like Growth Factor I;Interruption;Intervention;Malignant neoplasm of prostate;Malignant Neoplasms;men;Modeling;Molecular;molecular subtypes;mouse model;mTOR Inhibitor;Mus;mutant;Mutation;Nature;NCOA3 gene;Neoplasms;Newly Diagnosed;novel;novel diagnostics;novel therapeutic intervention;Oncogenic;Organoids;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Patients;pharmacologic;Phenotype;Phosphatidylinositols;Phosphotransferases;Prostate;prostate carcinogenesis;Proteome;Publications;receptor;Receptor Signaling;Recurrence;Regulation;Reporting;Role;Sampling;Signal Pathway;Signal Transduction;targeted treatment;Testing;The Cancer Genome Atlas;Therapeutic;Therapeutic Intervention;therapeutic target;translational impact;ubiquitin-protein ligase;Up-Regulation

PROJECT_TITLE: Coordinate Regulation of Oncogenic Signaling Pathways in SPOP Mutant Prostate Cancer

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Rural Health;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Mayo Clinic has a long tradition of clinical research and has been a supporter and active participant in the National Clinical Trials Network (NCTN). With over 1.3 million unique patients seen each year (of which over 120,000 are patients with cancer), Mayo Clinic is committed to making clinical trials available to all patients regardless of their racial, ethnicity, or socioeconomic background. A major factor in allowing this to occur is through Mayo Clinic's commitment to making NCTN trials a prominent part of its portfolio of clinical trials for cancer patients or patients at-risk for cancer.

PI_NAMEs: BOUGHEY, JUDY CAROLINE (contact);MANSFIELD, AARON SCOTT

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Advocate;American College of Radiology Imaging Network;Applications Grants;Arizona;Awareness;cancer care;cancer clinical trial;Cancer Patient;cancer risk;Cancer Science;Catchment Area;Clinic;Clinical Research;clinical trial enrollment;Clinical Trials;Clinical Trials Network;cognitive computing;Collaborations;Conduct Clinical Trials;Data;Development;Discipline;Disease;Eastern Cooperative Oncology Group;Ensure;Ethnic Origin;Florida;Focus Groups;Funding;Grant;Gynecologic Oncology Group;Health Disparities Research;Individual;innovation;Institution;International;Journals;Lead;Leadership;Malignant Neoplasms;Mayo Clinic Cancer Center;meetings;member;Mentors;Methods;Minnesota;Minority Enrollment;Minority Groups;Monitor;National Clinical Trials Network;National Surgical Adjuvant Breast and Bowel Project;North Central Cancer Treatment Group;Outcome;Participant;Patient Care;Patients;Physicians;programs;Publications;Publishing;Race;recruit;Research;Research Personnel;Role;Rural;Rural Population;Site;socioeconomics;Special Population;Strategic Planning;success;Underserved Population;Universities

PROJECT_TITLE: NCI, National Clinical Trials Network Lead Academic Participating Site (LAPS) UG1


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE: PUBLIC HEALTH RELEVANCE Cranial neural crest cells are essential for the formation of diverse craniofacial structures including bones and cartilage as well as portions of cranial ganglia; as such, defects in cranial neural crest specification, epithelial- to-mesenchymal transition, and differentiation are root to many craniofacial birth defects including craniosynestosis, Treacher Collins and CHARGE syndromes. This project will identify the mechanisms that control BMP signaling during its essential roles in cranial neural crest specification and will determine the molecular function of BMP signaling during cranial neural crest epithelial-to-mesenchymal transition. The results will provide significant and novel avenues for translational approaches to prevent and treat neural crest-derived craniofacial birth defects.

PI_NAMEs: PIACENTINO, MICHAEL LOUIS (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Binding;Biology;Body System;bone;bone morphogenetic protein receptors;California;career;Cartilage;cell type;Cells;Cephalic;CHARGE syndrome;Chick;Childhood;chromatin immunoprecipitation;Cleft Palate;Clustered Regularly Interspaced Short Palindromic Repeats;comparison control;Congenital Abnormality;craniofacial;Craniofacial Abnormalities;craniofacial development;craniofacial disorder;craniofacial structure;Data Set;Defect;Dentin;Development;Diffusion;DiGeorge Syndrome;Ectoderm;Embryo;embryo cell;Environment;Epidermis;epithelial to mesenchymal transition;Event;experience;experimental study;extracellular;Face;Ganglia;Gastrula;gastrulation;Genes;Genetic Epistasis;Goals;Image;in silico;in vivo;in vivo Model;Individual;Inhibitor of Differentiation Proteins;Lateral;Lead;Ligands;loss of function;Mandibulofacial Dysostosis;mathematical model;Measures;Medial;Mentors;Molecular;morphogens;neural;Neural Crest;Neural Crest Cell;neural plate;novel;Pathway interactions;Peptide Hydrolases;Peripheral;Peripheral Nervous System;Phase;Play;Population;prevent;programs;public health relevance;Reaction;receptor expression;Regulation;Reporter;Research;response;Role;Signal Pathway;Signal Transduction;Skeleton;spatiotemporal;Specific qualifier value;System;Systems Biology;Technology;Testing;Therapeutic;timeline;tool;Tooth structure;Training;transcriptome sequencing;translational approach

PROJECT_TITLE: Characterizing the cranial neural crest response to BMP signaling through gastrulation and neurulation

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Chronic Pain;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Pain Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE As the opioid epidemic has made clear, there is significant need to develop new ways to study chronic pain and relief of pain in preclinical models. Development of an accurate and broadly useful machine learning model and web-based platform will make it possible for researchers to objectively quantify and study spontaneous pain in mice, and hence provide a way to more rapidly identify and validate new analgesic drugs.

PI_NAMEs: ZYLKA, MARK J. (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Acetic Acids;addiction;Adopted;Adoption;Analgesics;analytical tool;Animal Model;associated symptom;Biological Assay;Black Box;Body Regions;Cellular Phone;Characteristics;chronic pain;Classification;cloud based;Color;Color blindness;Computer software;Computers;convolutional neural network;Custom;Data;Data Analytics;data repository;Database Management Systems;deep neural network;Dependence;Development;efficacy evaluation;Face;Facial Expression;Facial Pain;Failure;Future;Genes;Goals;handheld mobile device;Human;Human Resources;Image;improved;inflammatory pain;interest;Laparotomy;machine learning algorithm;machine learning model;Manuals;Maps;Measures;Medicine;Methods;mobile application;Modality;Modeling;Motion;multimodality;Mus;neural circuit;Neural Network Simulation;Non-Steroidal Anti-Inflammatory Agents;novel;open source;Opioid Analgesics;opioid epidemic;Output;overdose death;Pain;Pain intensity;Pain Measurement;pain relief;painful neuropathy;persistent symptom;Pharmaceutical Preparations;Postoperative Pain;pre-clinical;Pre-Clinical Model;Publishing;recurrent neural network;Reproducibility;Research Personnel;Resources;Rodent;Science;Screening procedure;side effect;Sleep;smartphone application;Specificity;spontaneous pain;success;System;Testing;Time;tool;Training;transfer learning;user-friendly;web platform;web services

PROJECT_TITLE: Development of a deep neural network to measure spontaneous pain from mouse facial expressions

STUDY_SECTION: SPS

STUDY_SECTION_NAME: Somatosensory and Pain Systems Study Section[SPS]


NIH_SPENDING_CATS: Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Narrative The goal of this clinical trial is to improve current functional magnetic resonance imaging (fMRI) language mapping practices for diagnostic neurosurgical planning, including for patients with pre-existing language deficits. The movie-watching language mapping test that will be developed uses naturalistic stimuli predicted to engage more completely the neural networks supporting language in real life. Our goal is to test and publicly share a novel method of comprehensive language mapping which is applicable in more neurosurgical patients, especially those with language deficits.

PI_NAMEs: LIEBENTHAL, EINAT ;TIE, YANMEI  (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Affect;American;Aphasia;Area;Attention;Behavior assessment;Brain Mapping;Brain Neoplasms;Clinical;Clinical Trials;Clinical Trials Cooperative Group;Clip;Cognitive;Cognitive deficits;cognitive function;Comprehension;Decision Making;Diagnostic;Diffusion Magnetic Resonance Imaging;Electrophysiology (science);Epilepsy;Equilibrium;Evaluation;Excision;Fostering;Functional Magnetic Resonance Imaging;functional MRI scan;Future;Generations;Glioma;Goals;Head;improved;indexing;Individual;Intervention;Language;Language Disorders;language impairment;language outcome;Life;Maps;Mediating;Methods;Modeling;Morphologic artifacts;Motion;movie;multimodality;neural network;neuroimaging;Neurologic;Neurosurgeon;neurosurgery;novel;novel diagnostics;Operative Surgical Procedures;Paper;Patients;Performance;phonology;Postoperative Period;preservation;Quality of life;Recommendation;response;Rest;risk mitigation;Scanning;Semantics;Sensitivity and Specificity;Severities;Societies;Specificity;Standardization;Stimulus;stroke-induced aphasia;support network;surgical risk;Task Performances;Testing;web site;white matter

PROJECT_TITLE: Naturalistic Neuroimaging for Presurgical Language Mapping

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-N(02)M]


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Immunotherapy;Infectious Diseases

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Narrative This project aims to deliver sialidase to exhausted tumor infiltrating T cells to enhance the efficacy of current checkpoint inhibitor therapies directed to stimulate the T cell arm of the adaptive immune system. These agents will be evaluated for their therapeutic benefit in animal models of cancer.

PI_NAMEs: PAULSON, JAMES C (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Adaptive Immune System;Animal Cancer Model;anti-PD-1;anti-PD-L1;Antibodies;antibody-dependent cell cytotoxicity;Antigen-Presenting Cells;Antigens;arm;Binding;Blocking Antibodies;C-terminal;cancer cell;cancer immunotherapy;cancer infiltrating T cells;CD28 gene;CD80 gene;CD86 gene;Cells;checkpoint therapy;chronic infection;Clinical;Colon Carcinoma;CT26;CTLA4 gene;effector T cell;Engineering;Epidermal Growth Factor Receptor;epimerase;ERBB2 gene;Excision;exhaust;exhaustion;Flow Cytometry;Gene Activation;Green Fluorescent Proteins;high dimensionality;Human;Immune;immune checkpoint;immune checkpoint blockade;Immune checkpoint inhibitor;immunogenic;Immunoglobulins;Immunologics;immunoregulation;In Vitro;in vivo;ITIM;Lectin;Leucocytic infiltrate;Leukocytes;Ligands;Ligation;lymph nodes;Lymphocyte Activation;Lymphocytic choriomeningitis virus;Major Histocompatibility Complex;Malignant Neoplasms;MC38;Melanoma;Modeling;Monitor;Mucins;Mus;N-terminal;Neoplasm Metastasis;Neuraminidase;Peptidyltransferase;Play;polyglycine;Polysaccharides;programmed cell death ligand 1;programmed cell death protein 1;Proteins;Reagent;receptor;Refractory;response;Role;sialic acid binding Ig-like lectin;Sialic Acids;sialylation;Signal Transduction;Solid Neoplasm;sortase;Source;T-Cell Activation;T-Cell Proliferation;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Therapeutic;Therapeutic Effect;Time;tumor;tumor growth;Tumor Immunity;tumor progression;Tumor-associated macrophages;Tyrosine

PROJECT_TITLE: Removing sialic acid ligands of CD28 to enhance T cell cancer immunotherapy

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Clinical Research;Hematology;Hodgkin's Disease;Lymphatic Research;Lymphoma;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: OAKLAND

ORG_NAME: PUBLIC HEALTH INSTITUTE

PHR: Project Narrative Hematopoietic Malignancies (HM) are a major cause of cancer deaths in children. The Children’s Oncology Group’s (COG) Hematopoietic Malignancies Integrated Translational Science Center (HM-ITSC), integrated into the functional organization of COG, will provide resources to support translational research in pediatric leukemia/lymphoma towards identification of actionable targets and their incorporation into clinical trials. 1

PI_NAMEs: MESHINCHI, SOHEIL  (contact)

PROJECT_TERMS: Acceleration;Acute Lymphocytic Leukemia;Acute Myelocytic Leukemia;Acute Promyelocytic Leukemia;Address;Adult;Area;B-Lymphocytes;Biological;Biological Markers;Biological Sciences;Biology;Cancer Biology;Cancer Etiology;Cause of Death;Center for Translational Science Activities;Child;Child Care;Child Support;Childhood;childhood cancer mortality;Childhood Leukemia;Childhood Lymphoma;Classification;Clinic;Clinical;clinical application;clinical implementation;clinical practice;Clinical Research;Clinical Trials;Clinical Trials Cooperative Group;clinically actionable;clinically relevant;Cytotoxic Chemotherapy;Data;design;Developmental Therapeutics Program;Diagnostic;Disease;Elements;Ensure;Eosinophilic Granuloma;epigenomics;Evaluation;Fostering;fundamental research;Funding;Generations;Genomic approach;Genomics;Goals;Grant;Guidelines;Hematologic Neoplasms;Hematopoietic;Hematopoietic Neoplasms;Heterogeneity;Hodgkin Disease;improved;improved outcome;Infrastructure;innovation;Intervention;Juvenile Myelomonocytic Leukemia;Laboratories;Leadership;leukemia/lymphoma;Link;Malignant Childhood Neoplasm;Malignant Neoplasms;Microscopy;Molecular;molecular diagnostics;molecular marker;Morphology;Multi-Institutional Clinical Trial;new therapeutic target;Non-Hodgkin's Lymphoma;North America;novel;novel marker;operation;Outcome;outcome prediction;Patients;Pediatric Neoplasm;Pediatric Oncology Group;personalized approach;Phase;Pilot Projects;pre-clinical;prevent;programs;prospective;quality of life for cancer survivors;Relapse;Research;Research Project Grants;research study;Resources;Risk;risk stratification;Solid;statistics;Structure;success;Survivors;T-Lymphocyte;targeted treatment;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutic target;Therapeutic Trials;Therapeutic Uses;Translating;Translational Research;Translations;Treatment Efficacy;Validation;Variant;young adult

PROJECT_TITLE: COG NCTN Integrated Translational Science Center for Hematopoietic Malignancies in Children


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cancer;Clinical Research;Neurosciences;Radiation Oncology

PHR: PROJECT NARRATIVE  This R21 proposal seeks to develop a cell-size-based MRI technique, Selective Size MR Imaging using Filters via diffusion Times (SSIFT), as a novel approach for imaging brain metastases in patients with high specificity, and to evaluate its potential to differentiate recurrent metastatic brain cancer from radiation necrosis induced by stereotactic radiosurgery.

PI_NAMEs: XU, JUNZHONG  (contact)

PROGRAM_OFFICER_NAME: KIM, BOKLYE

PROJECT_TERMS: accurate diagnosis;Address;Animal Model;Biopsy;Blood - brain barrier anatomy;Brain;brain abnormalities;brain cell;Brain imaging;Brain Neoplasms;brain tissue;cancer cell;Cancer Patient;Cell Size;cell type;Clinic;Clinical;clinical imaging;common treatment;Computer Assisted;Contrast Media;Cranial Irradiation;Development;Diagnosis;diagnostic accuracy;Diffusion;diffusion anisotropy;Dimensions;Early Diagnosis;Edema;effective therapy;Enhancing Lesion;Foundations;Gadolinium;Image;imaging approach;imaging biomarker;imaging modality;improved;kidney dysfunction;Lesion;Liquid substance;Magnetic Resonance Imaging;Malignant neoplasm of brain;Malignant Neoplasms;Metastatic malignant neoplasm to brain;Metastatic/Recurrent;Methods;Monitor;Morbidity - disease rate;multidisciplinary;Necrosis Induction;Neoplasm Metastasis;non-invasive imaging;Non-Small-Cell Lung Carcinoma;novel strategies;Operative Surgical Procedures;Patients;perfusion imaging;pre-clinical;Process;Protocols documentation;Radiation;Radiation necrosis;Radiation Oncology;Radiosurgery;Recurrence;Recurrent tumor;reduce symptoms;Scanning;Signal Transduction;Source;Specificity;Spectrum Analysis;standard of care;Structure;Techniques;Testing;Time;tumor;tumor progression;Validation;Variant;vasogenic edema;Work

PROJECT_TITLE: Differentiation of tumor progression from radiation necrosis using MR cell size imaging


NIH_SPENDING_CATS: Bioengineering;Rare Diseases

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Release of calcium ions from their intracellular storage location in skeletal muscle due to physiological muscle fiber depolarization is a prerequisite for all skeletal muscle activity, including that involved in locomotion and breathing. Here we first study how individual regions of the voltage sensing molecule for muscle activation function to turn on muscle calcium release in normal muscle during normal activation. We then study how disease mutations of the voltage sensing molecule alter its functional properties, thereby contributing to the disease status.

PI_NAMEs: HERNANDEZ-OCHOA, ERICK OMAR (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Action Potentials;Adult;advanced disease;Aging;Amino Acids;Biophysics;Breathing;Calcium;Calcium ion;cell type;Charge;Closure by clamp;confocal imaging;Coupling;Cytoplasm;Discipline;Disease;disease-causing mutation;electrical measurement;Environment;extracellular;Fiber;Fluorometry;Functional disorder;Housing;human disease;Hypokalemic periodic paralysis;Individual;interest;Ion Channel;Label;Link;Location;Locomotion;Malignant hyperpyrexia due to anesthesia;Mammalian Cell;Measurement;Measures;Mediating;Membrane;Molecular;molecular domain;Monitor;Movement;Muscle;Muscle Fibers;Mutate;Mutation;Neuromuscular Junction;Oocytes;Physiological;Property;Publications;Radial;Reaction;Reagent;receptor coupling;response;Role;Ryanodine Receptor Calcium Release Channel;Sarcoplasmic Reticulum;Scanning;sensor;Signal Transduction;Skeletal Muscle;Speed;Stains;Stimulus;System;Time;Variant;voltage;voltage clamp;voltage gated channel

PROJECT_TITLE: Voltage sensor domain movements in skeletal muscle fiber activation


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Aging;Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Rehabilitation;Stroke

ORG_CITY: RICHARDSON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

ORG_STATE: TX

PHR: Project Narrative Aphasia is an acquired speech/language deficit most commonly resulting from left-hemisphere stroke and is a leading cause of communication disability in the United States posing a significant barrier to professional, social, and family participations. Our proposed research meets public health needs by providing unique insights into the neural bases of vocal sensorimotor deficits that underlie impaired communication in aphasia. This knowledge will inform targeted treatment of sensorimotor mechanisms to help enhance communication ability and improve the quality of life in affected individuals.

PI_NAMEs: BEHROOZMAND, ROOZBEH  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acoustics;acute stroke;Affect;Anatomy;Aphasia;Associative aphasia;auditory feedback;base;behavior measurement;Behavioral;Biological Markers;biomarker identification;Brain Injuries;chronic stroke;Communication;Communication Disability;Communication impairment;Complex;comprehension deficit;Computer Models;Data;Death Rate;Diagnosis;Diffusion Magnetic Resonance Imaging;disability;dorsal visual stream;Effectiveness;Electroencephalography;Electrophysiology (science);Event-Related Potentials;experience;Family;Feedback;Functional Magnetic Resonance Imaging;Generations;Goals;Human;Impairment;improved;indexing;Individual;individualized medicine;innovation;insight;Knowledge;Language;Language Disorders;Left;Lesion;Life;Life Expectancy;Lifelong disability;Location;Measures;Mission;Modality;Modeling;Motor;motor control;Motor output;MRI Scans;multimodality;National Institute of Neurological Disorders and Stroke;neural;neuroimaging;neuromechanism;Neuronal Plasticity;neurophysiology;novel;Outcome;Outcome Measure;Patients;Pattern;Play;Population;Positioning Attribute;Procedures;Process;Production;Public Health;Quality of life;Receptive aphasia;Regression Analysis;Rehabilitation Outcome;Research;Resolution;response;Role;Sensorimotor functions;Sensory;sensory feedback;sensory input;sensory integration;Signal Transduction;social;Source;Speech;Speech Disorders;Speech Therapy;Stream;Stroke;stroke patient;stroke-induced aphasia;targeted treatment;Time;tractography;Training;Translating;Treatment outcome;treatment strategy;United States;United States National Institutes of Health;Validation;Visual;visual feedback;Voice;white matter

PROJECT_TITLE: Neural Bases of Vocal Sensorimotor Impairment in Aphasia

STUDY_SECTION: SMI

STUDY_SECTION_NAME: Sensorimotor Integration Study Section[SMI]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Human Genome;Pediatric;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative This project addresses several issues of central importance to the understanding of congenital and acquired arrhythmias, significant causes of morbidity and mortality. This proposal tests the hypothesis that Wnt signaling transcriptionally regulates the expression of ion channel subunits that regulate cardiac conduction. The results and broad conclusions will be directly relevant to understanding the genetic basis of cardiac arrhythmias, and will aid in designing more effective diagnostic and therapeutic options for ventricular tachycardia.

PI_NAMEs: RENTSCHLER, STACEY LYNN (contact)

PROJECT_TERMS: Address;Adult;Affect;Arrhythmia;arrhythmogenic cardiomyopathy;beta catenin;Binding;Brugada syndrome;Cardiac;Cardiac Electrophysiologic Techniques;Cardiac Myocytes;Cardiovascular Pathology;Cause of Death;Cell Nucleus;Characteristics;Chromatin;clinically relevant;Complex;congenital heart abnormality;Copy Number Polymorphism;Data;design;Development;Diabetes Mellitus;Diagnostic;Disease;Drug Modulation;Electrophysiology (science);Elements;Embryo;Enhancers;Funding;gain of function;Gap Junctions;Genes;Genetic;Genetic Transcription;genome wide association study;genome-wide;Genomic Segment;Genomics;glycogen synthase kinase 3 beta;Glycogen Synthase Kinases;Heart;Heart Diseases;Heart failure;Human;human disease;improved;In Vitro;in vivo;Inherited;interest;Ion Channel;kinase inhibitor;Left;Left ventricular structure;Link;loss of function;Measures;Mediating;Modeling;Molecular;Morbidity - disease rate;Morphogenesis;mortality;mouse model;Mus;Mutagenesis;Myocardial;Myocardium;Neurodegenerative Disorders;notch protein;Notch Signaling Pathway;Nuclear;Nucleic Acid Regulatory Sequences;Pathway interactions;patient population;Patients;Pattern;Phenocopy;posttranscriptional;Predisposition;Protein Isoforms;Protein Kinase;Proteins;Publishing;Regulation;Regulatory Element;Reporting;Right ventricular structure;Role;Signal Transduction;Single Nucleotide Polymorphism;Slice;Sodium Channel;structural heart disease;Surgical Models;Testing;Therapeutic;therapeutic target;Tissues;Transcript;transcriptome sequencing;Transgenic Organisms;Translating;Translations;Tricuspid Atresia;Untranslated RNA;Variant;Ventricular;Ventricular Arrhythmia;Ventricular Tachycardia;WNT Signaling Pathway

PROJECT_TITLE: Wnt Signaling in Cardiac Conduction and Arrhythmogenesis

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Lung;Pediatric;Prevention;Transplantation;Vaccine Related

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE Immune responses in children are known to be distinct, setting the stage for a lifetime of health or disease. This proposal is designed to explore the hypothesis that pediatric T cell responses are shaped by factors inherent to the cell, its tissue environment, and the individual's infection history. The knowledge gained by this study will provide novel insights into early life immune development which will improve our ability to prevent and treat childhood and lifelong diseases.

PI_NAMEs: FARBER, DONNA L. (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: 2019-nCoV;adaptive immune response;adaptive immunity;Address;Adult;Age;Antibodies;Antibody Response;Antigen-Presenting Cells;Antigens;antiviral immunity;Blood;Blood specimen;Cell division;Cell Maturation;Cells;Child;Childhood;Clinical;cohort;Collaborations;COVID-19;COVID-19 pandemic;COVID-19 vaccine;design;Development;Disease;Effector Cell;Environment;Event;Evolution;Exhibits;experience;Exposure to;Gene Expression;Gene Expression Profile;Generations;Genes;Health;high dimensionality;Homing;Human;human tissue;Immune;Immune response;Immune system;Immunity;Immunologic Memory;immunological synapse;Immunotherapy;improved;Individual;infancy;Infant;Infection;Inflammatory;Influenza;insight;Intestines;Knowledge;Laboratories;Life;Lung;Mediating;Modeling;Molecular Profiling;mouse model;mucosal site;Mucous Membrane;Multisystem Inflammatory Syndrome in Children;Mus;Nature;next generation;novel;Organ Donor;Organ Procurements;pathogen;pathogenic virus;Pathway interactions;Pediatric cohort;pediatric patients;Phenotype;Population;Predisposition;prevent;Process;Proliferating;Property;Recording of previous events;respiratory;respiratory infection virus;respiratory virus;response;RNA vaccine;Role;Sampling;SARS-CoV-2 immunity;SARS-CoV-2 infection;Shapes;Signal Transduction;Site;symptomatic COVID-19;Syndrome;Systems Development;T cell differentiation;T cell response;T memory cell;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Time;Tissue Donors;tissue resident memory T cell;Tissue Sample;Tissues;transcriptomic profiling;Vaccination;Vaccines;Virus

PROJECT_TITLE: Evolution of T cell immunity in blood and tissues over childhood


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Pediatric;Pediatric Cardiomyopathy;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

PHR: NARRATIVE Ventricular arrhythmia and sudden cardiac death is a consequence of hypertrophic cardiomyopathy (HCM) especially in young adults. Although SCD can be effectively managed by implantation of an implantable cardioverter defibrillator (ICD), these devices cause lifestyle and occupational restrictions and negatively affect quality of life. Since the risk of SCD is variable and poorly understood, there is a critical need to understand the underlying mechanisms. A mechanistic understanding will aid in developing tools to predict SCD risk so that only those patients in need receive ICDs and to develop therapeutics that might be more effective than current options.

PI_NAMEs: MERCOLA, MARK  (contact)

PROJECT_TERMS: Address;Affect;Arrhythmia;Biological Process;Biology;calmodulin-dependent protein kinase II;Cardiac Myocytes;causal variant;Cell Line;Cells;Classification;Clinical;Complex;Complication;Consensus;Data;design;Development;Devices;Disease;Disease Progression;Drug Targeting;Evaluation;Familial Hypertrophic Cardiomyopathy;Fingerprint;functional genomics;Gene Mutation;Gene Proteins;Genetic;genetic variant;Genomic approach;Genotype;Goals;Heart Diseases;Hypertrophic Cardiomyopathy;Implantable Defibrillators;implantation;improved;In Vitro;in vivo;in vivo evaluation;Individual;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;insight;knock-down;Knockout Mice;Knowledge;Lead;Life Style;Link;Mediator;MicroRNAs;Modeling;Molecular;mortality risk;mouse model;Mus;Muscle Cells;Muscle Contraction;Muscle relaxation phase;mutant;mutant mouse model;Mutant Strains Mice;Mutate;Mutation;network models;novel;novel therapeutic intervention;Occupational;Pathogenicity;Pathway interactions;Patients;Phenotype;Predisposition;prevent;Process;prognostic;Prognostic Marker;prognostic tool;protein protein interaction;Proteins;Publishing;Quality of life;Research;Risk;Sampling;screening;Signal Pathway;Signal Transduction;sudden cardiac death;Tachycardia;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Thick Filament;Thin Filament;Tissues;tool;Transgenic Mice;Validation;Variant;Ventricular Arrhythmia;Ventricular Tachycardia;young adult

PROJECT_TITLE: Targeting the genotype to phenotype link in HCM as a therapeutic strategy

STUDY_SECTION: ESTA

STUDY_SECTION_NAME: Electrical Signaling, Ion Transport, and Arrhythmias Study Section[ESTA]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: DURHAM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE The project is relevant to public health because defects in astrocyte development, especially those affecting astrocyte numbers or patterning, have been linked to disorders of retinal vascular development such as reti- nopathy of prematurity. Further, death by phagocyte may mediate neuron loss in certain neurodegenerative disorders. Therefore, by pinpointing the mechanisms underlying death by phagocyte, the proposed research is expected to reveal mechanisms that one day may be manipulated for therapeutic benefit – to promote normal retinal angiogenesis or to inhibit neuron loss.

PI_NAMEs: KAY, JEREMY N (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Acute;Affect;angiogenesis;Apoptosis;Astrocytes;Automobile Driving;Biological Assay;Blood Vessels;Candidate Disease Gene;Cell Death;Cell surface;cell type;Cells;Central Nervous System;Cessation of life;Characteristics;conditional mutant;Cues;Data;Defect;density;Development;Disease;Eating;Excision;Gene Expression Profile;Genes;Genetic;genetic manipulation;Genetic Transcription;gliovascular;Goals;Human;in vivo;in vivo evaluation;insight;Knock-out;Knowledge;Learning;Link;Mediating;Mediator;Membrane Lipids;Metabolic;Metabolic stress;Microglia;Mitochondria;mitochondrial metabolism;Molecular;Mus;Mutant Strains Mice;neonatal mice;Nerve Fibers;Nervous System;nervous system development;Neurodegenerative Disorders;neuron loss;novel;Outcome;Output;Pathologic;Pattern;Pattern Formation;Phagocytes;Phagocytosis;Phosphatidylserines;photoreceptor degeneration;Population;Population Sizes;Positioning Attribute;prevent;programs;Public Health;Publishing;recruit;Research;respiratory;response;Retina;retina circulation disorder;retinal angiogenesis;Retinal Degeneration;Retinopathy of Prematurity;Role;selective expression;Shapes;Signal Transduction;single-cell RNA sequencing;Stress;stressor;System;Testing;Therapeutic;transcription factor;uptake;Vascular Diseases;Vision;Work

PROJECT_TITLE: Mechanisms of naturally-occurring astrocyte death during retinal development


NIH_SPENDING_CATS: Autoimmune Disease;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease;Microbiome

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: NARRATIVE Inflammatory bowel disease (IBD) is a complex, multifactorial condition that involves multiple aspects of the intestinal mucosa, microbiome, and immune system. We propose novel experimental and mechanistic studies to determine the role of heterogeneous chemosensory tuft cells in suppressing ileal inflammatory disease. These studies may provide a greater understanding of microbiome-host crosstalk in the intestine while also broadening the small pool of therapeutic targets in IBD.

PI_NAMEs: LAU, KEN S (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Ablation;Affect;Antigens;Architecture;Biological Assay;Cell Lineage;cell type;Cells;Cellular biology;Chemical Models;Chemicals;Communication;Complementary therapies;Complex;Computer Analysis;Country;Crohn's disease;cytokine;Cytometry;Cytoskeleton;Dependence;design;Developed Countries;Diagnosis;Disease;disease model;disorder subtype;Electron Microscopy;Enzyme-Linked Immunosorbent Assay;Epithelium;Fluorescence;Genetic;genetic manipulation;Genetic Models;Goals;helminth infection;Heterogeneity;host microbiome;Human;Hygiene;Ileal Diseases;Immune;Immune response;Immune system;Immunofluorescence Microscopy;immunoregulation;in vivo Model;Incidence;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;innovation;Intestinal Mucosa;Intestines;Knowledge;longitudinal analysis;microbiome;microbiota;Microscopy;Modeling;mouse model;Mucous Membrane;multiplexed imaging;Mus;novel;Organ;Organoids;Parasites;Parasitic Diseases;Parasitic infection;Pathway interactions;patient stratification;Patients;Population;Population Heterogeneity;Precision therapeutics;Predisposition;PTGS2 gene;Research;Resolution;response;Rest;Role;Rosaniline Dyes;Sampling;Sensory;Sentinel;single cell sequencing;single-cell RNA sequencing;Small Intestines;Sorting;Specific qualifier value;Specimen;Stains;Structure;Structure-Activity Relationship;Testing;Therapeutic;therapeutic target;Time;Tissues;transcription factor;translational applications;tumor-immune system interactions;ultra high resolution;Work

PROJECT_TITLE: Tuft cell heterogeneity in function, lineage, and structure in ileal inflammatory disease

STUDY_SECTION: GMPB

STUDY_SECTION_NAME: Gastrointestinal Mucosal Pathobiology Study Section[GMPB]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Neurosciences;Prevention;Substance Misuse

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

PHR: Project Narrative In recent decades, the prevalence of cannabis use has significantly increased among older adults (≥65 years), a population that is particularly vulnerable to cognitive impairment associated with cannabis use. This proposed project leverages existing nationally representative data and digital epidemiology tools to identify detailed patterns of cannabis use and the associations between those patterns and residual cognitive impairment, across several domains, in older US adults. Findings from this project will inform clinicians, researchers, and policymakers about the risks of cognitive impairment in older adults with different patterns of cannabis use, and subsequently, about the development of harm reduction strategies.

PI_NAMEs: LIVNE, OFIR  (contact)

PROGRAM_OFFICER_NAME: PARKER, ERIN MARGARET

PROJECT_TERMS: Acute;Address;adolescent drug use;Adult;age group;Aging;aging population;Attention;Attitude;baby boomer;Benefits and Risks;Biometry;Brain;Cannabis;cannabis use behavior;career;career development;causal model;Clinical;Cognition;Cognitive;cognitive function;cognitive testing;cohort;Consumption;cost;cost effective;Data;Data Analyses;Data Collection;design;Development;Development Plans;digital;digital tool;Elements;Epidemiology;executive function;Feasibility Studies;Frequencies;Goals;Harm Reduction;Health;Health and Retirement Study;health data;Heterogeneity;human old age (65+);Impaired cognition;Impairment;Individual;insight;interest;Intervention;Intoxication;K-Series Research Career Programs;Linear Models;longitudinal analysis;Longitudinal Studies;marijuana use;marijuana user;Measures;Mentors;Mentorship;Methods;middle age;Motivation;National Institute of Drug Abuse;Neurocognitive;neuropsychiatric disorder;Neuropsychology;normal aging;novel;older adult;online delivery;Outcome;Pattern;Pilot Projects;Policy Maker;Population;Prevalence;Prevention strategy;preventive intervention;Public Health;Recording of previous events;Records;recruit;Research;Research Personnel;Research Proposals;Residual state;Respondent;response;Risk;risk perception;Route;Sampling;secondary analysis;Self Administration;Short-Term Memory;skills;social media;sociodemographics;Structure;substance use;Substance Use Disorder;substance use treatment;substance user;Surveys;Therapeutic Intervention;tool;Training;Training Programs;trend

PROJECT_TITLE: Cannabis use patterns and associations with cognitive impairment in older adults

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Duchenne/ Becker Muscular Dystrophy;Genetics;Muscular Dystrophy;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: PROJECT NARRATIVE Duchenne muscular dystrophy (DMD) is known for causing progressive muscle wasting and death. It is less well known that DMD patients also have intellectual disorders that arise from problems in brain development. My aims are designed to determine the role of the DMD gene in brain development to assist in discovering therapeutics that address the causes of the abnormalities and improve outcomes for individuals with DMD.

PI_NAMEs: ARREGUIN, ANDREA JASMINE (contact)

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: Actins;Address;Adult;Affect;Animal Model;Binding;Brain;brain abnormalities;Cell Culture System;Cell Culture Techniques;Cell Nucleus;Cells;Cerebral Ventricles;Cessation of life;Cognitive;Cognitive deficits;Corpus Callosum;Cytoplasm;Cytoskeleton;design;Development;Disease;Duchenne muscular dystrophy;Dystroglycan;Dystrophin;Electroporation;Ensure;Ependymal Cell;experimental study;Extracellular Matrix;Functional disorder;Gene Expression;Generations;Genes;Genetic Transcription;gliogenesis;gray matter;improved outcome;In Situ;In Vitro;in vivo;Individual;insight;Intellectual functioning disability;Knowledge;Length;Link;Membrane;Modification;Molecular;mouse model;Mus;Muscle Cells;muscle progenitor cell;Muscular Atrophy;muscular dystrophy mouse model;Mutation;myelination;Myoblasts;Neonatal;nerve stem cell;neural model;Neurologic Dysfunctions;Neurologic Process;Neurons;Neurosphere;notch protein;novel;Nuclear;Nuclear Import;oligodendrocyte progenitor;Oligodendroglia;Outcome;Output;Pathway interactions;Patients;Perinatal;Phenotype;Play;postnatal;prevent;Production;progenitor;promoter;Prosencephalon;Protein Isoforms;Proteins;receptor;Reporter;Reporting;Role;Severities;Signal Transduction;Skeletal Muscle;stem;Stem Cell Development;stem cell niche;stem cells;subventricular zone;Supporting Cell;Testing;Therapeutic;transcription factor;Transgenic Organisms;Ventricular;white matter

PROJECT_TITLE: Exploration of developmental brain abnormalities in mouse models of Duchenne muscular dystrophy


NIH_SPENDING_CATS: Aging;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_NAME: TUFTS MEDICAL CENTER

PHR: PROJECT NARRATIVE Human babesiosis caused by the hemoparasite Babesia microti is an emerging infectious disease in the United States. Current prophylactic measures aim at reducing exposure to the Ixodes scapularis tick, the vector that maintains Babesia microti in its enzootic cycle and incidentally feeds on humans. Using mouse strains that model severe Babesia microti infection caused by old age or severe immune suppression, the proposed research will seek to identify tafenoquine regimens that confer post-exposure prophylaxis.

PI_NAMEs: VANNIER, EDOUARD G (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Adoptive Transfer;Age;Age Years;Anemia;Anorexia;Antimicrobial Resistance;Area;Babesia microti;Babesiosis;Bite;Black-legged Tick;Blood;Borrelia microti;Caring;Case Study;Cessation of life;Chemoprophylaxis;Chills;Chloroquine;Clinical Trials;Data;Dose;Drug Exposure;Drug Kinetics;Elderly;Emerging Communicable Diseases;enzootic;Evaluation;Exposure to;FDA approved;Feeds;Fever;Glucosephosphate Dehydrogenase Deficiency;Headache;Hospitalization;Human;human old age (65+);Immune response;Immunocompromised Host;Immunosuppression;Inbred BALB C Mice;Incidence;Individual;Infection;Kidney Failure;liquid chromatography mass spectrometry;Maintenance;Malaria;Measures;Medical;Modeling;Monitor;Mouse Strains;Mus;Myalgia;old mice;Outcome;Parasitemia;Plasma;Plasmodium vivax;pre-exposure prophylaxis;preclinical study;prophylactic;Prophylactic treatment;Protocols documentation;Regimen;Relapse;Research;Resolution;Risk Factors;Symptoms;Testing;Therapeutic;Tick-Borne Diseases;Ticks;Travel;United States;Vaccines;vector;Work

PROJECT_TITLE: Evaluation of tafenoquine for prophylaxis of babesiosis caused by Babesia microti

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-B(82)]


NIH_SPENDING_CATS: Asthma;Clinical Research;Genetics;Lung

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Asthma is a major health care burden to patients, families, and societies. The management of asthma is far less than ideal, in part due to our incomplete understanding of cellular and molecular processes of asthmatic inflammation. This proposal seeks to determine the novel mechanism of the resolution of allergic inflammation, specifically focusing on a specialized cell type that is responsible for clearing inflammatory cells and their debris to facilitate the resolution of inflammation. The proposed study would lead to a better understanding of pathogenesis of asthma, eventually improving the management of asthma.

PI_NAMEs: PARK, GYE YOUNG  (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: Active Sites;Adopted;airway inflammation;Allergens;Allergic;Allergic inflammation;Alveolar Macrophages;Apoptotic;Asthma;asthma model;asthmatic;Binding;Biological Assay;Bronchial Provocation Tests;CCL26 gene;Cell Death;Cell Physiology;cell type;Cells;Characteristics;chemokine;Complement 1q;conditional knockout;CX3CL1 gene;Cytometry;Data;eosinophil;Eosinophilia;Excision;experimental study;Extrinsic asthma;Family;Functional disorder;gain of function;Gene Expression Profile;Gene Expression Profiling;healthcare burden;Homeostasis;Human;improved;In Vitro;in vivo;in vivo Model;Infiltration;Inflammation;Inflammatory;inflammatory lung disease;insight;Institutional Review Boards;Investigation;life span;Ligands;Liquid substance;Lung;Macrophage;Macrophage Activation;Mediating;Modeling;Molecular;Morphology;mouse model;Mus;novel;Organ;Pathogenesis;Pathway interactions;Patients;Phagocytes;Phase;Phenotype;Play;Prevention;Process;Protocols documentation;pulmonary function;Pulmonary Inflammation;receptor;recruit;Refractory;Reporter;Research;Resolution;response;Role;Series;sialic acid binding Ig-like lectin;single-cell RNA sequencing;Site;Societies;Source;Structure of parenchyma of lung;targeted treatment;Techniques;Testing;Time;Tissues;Transcript;Transgenic Mice;translation to humans;translational study

PROJECT_TITLE: Mechanism of CX3CR1+ macrophage-mediated resolution of eosinophilic allergic lung inflammation

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Bioengineering;Kidney Disease

ORG_NAME: BOSTON MEDICAL CENTER

PHR: Project Narrative This proposal is to establish a Boston University Kidney and Medical Engineering Program (BU-KIDMEP). Our program's focus is on providing undergraduate and graduate students in science, technology, engineering, and mathematics the opportunity to engage in kidney technology development research. Our ultimate goal is to inspire talented young scholars to improve the lives of individuals with kidney disease through innovative technology solutions.

PI_NAMEs: CHITALIA, VIPUL C;WAIKAR, SUSHRUT S. (contact);WONG, JOYCE Y

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Address;Advisory Committees;Affinity;American;Attention;Biomedical Engineering;Boston;Businesses;career;career development;Chemistry;Clinical;college;commercialization;Committee Members;Dedications;design;Development;Device or Instrument Development;Discipline;drug development;Education;Engineering;Entrepreneurship;Event;Evolution;experience;Exposure to;Faculty;Fostering;Foundations;Funding;Funding Opportunities;Future;Goals;Government;graduate student;Grant;Health Personnel;Hemodialysis;Immersion;improved;Individual;Industry;Infrastructure;innovation;innovative technologies;interest;International;invention;Kidney;Kidney Diseases;Life;materials science;Mechanics;Medical;medical specialties;Medicine;meetings;member;Mentors;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;novel therapeutics;Pathology;Patient Care;Patients;posters;Preparation;Process;programs;Public Health;Radiology Specialty;recruit;Research;Research Personnel;Resources;Schools;Science, Technology, Engineering and Mathematics;Societies;Students;success;symposium;System;Talents;Techniques;Technology;technology development;technology research and development;therapeutic development;Training;trend;undergraduate student;Universities;Work;Writing

PROJECT_TITLE: The Boston University Kidney and Medical Engineering Program (BU-KIDMEP)


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Drug Abuse (NIDA only);Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Microbiome;Prevention;Substance Misuse

ORG_CITY: NEW ORLEANS

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: NARRATIVE This study will utilize the ongoing people with people who inject drug (PWID) cohort in Puerto Rico and the information being collected on inflammation, microbial dysbiosis and HIV disease progression to determine the prevalence of SARS-CoV-2 infection in the cohort and its effects on HIV disease progression. The PWID is a high-risk group for infectious disease, but the effects of SAES-CoV-2 infection on HIV in this group has not been investigated, in either Puerto Rico or anywhere else. The results generated by our study can be translatable to the PWID in other parts of the U.S and may lead to the development of strategies to prevent HIV and COVID-19 disease progression in HIV+ PWID.

PI_NAMEs: WOOD, CHARLES  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: 2019-nCoV;Affect;Biological Markers;Blood specimen;Case Study;Cessation of life;co-infection;Cognition Disorders;cohort;Cohort Studies;Communicable Diseases;Control Groups;Coupled;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 prevalence;COVID-19 risk;Development;Disease;Disease Progression;drug of abuse;Drug usage;dysbiosis;Elderly;Epidemic;Evaluation;Future;Health;health disparity;Hepatitis;high risk;high risk population;HIV;HIV Infections;HIV Seronegativity;HIV-1;HIV/AIDS;Immune;immune activation;Immune response;Immunophenotyping;Incidence;Individual;Infection;Inflammation;Inflammation Mediators;Infrastructure;Injecting drug user;injection drug use;Injections;Kentucky;Knowledge;Lead;Location;Long-Term Effects;Longitudinal cohort;Longitudinal cohort study;Longitudinal Studies;Lymphoid;Maine;microbial;Midwestern United States;Morbidity - disease rate;mortality;Natural Disasters;Neurocognitive;non-drug;novel;Ohio;opioid epidemic;opioid injection;Parents;persistent symptom;Persons;Pharmaceutical Preparations;Phenotype;Population;Premature aging syndrome;Prevalence;prevent;prospective;Public Health;Puerto Rico;Recurrence;Research;Rest;Risk;SARS-CoV-2 infection;Site;Social Behavior;Substance abuse problem;Substance Use Disorder;synergism;systemic inflammatory response;T-Lymphocyte;Testing;Tissues;Treatment Failure;United States;US State;Vaccinated;Vaccines;Viral Load result;wasting;West Virginia

PROJECT_TITLE: Biomarkers for Dysbiosis-Related HIV-Associated Cognitive Disorders among Persons Who Inject Drugs in Puerto Rico


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Epilepsy;Neurodegenerative;Neurosciences;Pediatric;Sleep Research

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative RELEVANCE: Benign epilepsy with centrotemporal spikes (BECTS) is the most common childhood epilepsy syndrome, and recent findings indicate that BECTS is a disorder with a wider range of severity than previously appreciated. In addition to seizures, children have cognitive deficits that range from mild to profound, overlapping clinically, electrophysiologically, and genetically with severe epileptic encephalopathies. This project will determine whether abnormal thalamocortical circuitry mediates the cognitive symptoms in BECTS, thereby increasing our fundamental knowledge of the cause and treatment for this common developmental disease.

PI_NAMEs: CHU, CATHERINE J (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Absence Epilepsy;Acoustic Stimulation;Address;Attention;Benign;Cerebrum;Characteristics;Child;Childhood;childhood epilepsy;Clinical;Cognitive;Cognitive deficits;cognitive function;cognitive performance;common treatment;computerized tools;Data;density;Development;developmental disease;diagnostic criteria;Diazepam;Disease;Electrophysiology (science);Epilepsy;epileptic encephalopathies;epileptiform;Focal Seizure;Functional disorder;functional outcomes;Generalized seizures;Goals;Impaired cognition;Impairment;improved;indexing;Intervention;Knowledge;Learning;Link;Mediating;memory consolidation;Motor;motor deficit;motor impairment;motor learning;motor symptom;multimodal data;Neurobehavioral Manifestations;Neuropsychology;non rapid eye movement;Performance;Pharmaceutical Preparations;Physiology;Schools;Seizures;Sensory;sensory gating;Severities;Sleep;sleep abnormalities;Sleep Deprivation;Sleep disturbances;sleep spindle;Symptoms;Syndrome;Testing;treatment strategy;Work

PROJECT_TITLE: Focal Thalamocortical Circuit Dysfunction Mediates Motor and Cognitive Deficits in Developmental Epilepsy

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Millions of individuals suffer from skeletal muscle atrophy and contractile dysfunction (i.e. muscle weakness), a hallmark of several physiological and pathological conditions, including sarcopenia and cancer cachexia. Despite the significance of myopathy on quality of life and healthspan, no pharmacological therapies are currently available to mitigate the loss of muscle mass and function. The experiments in this proposal will test the impact of unacylated ghrelin on skeletal muscle weakness in aging and cancer cachexia with a high chance of translation based on its excellent safety profiles in humans and no effects on cancer cell growth.

PI_NAMEs: AHN, BUMSOO  (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Actomyosin;Acute;Acylation;Adult;Affect;age related;age related neurodegeneration;Aging;Animals;Applied Skills;Atrophic;Binding;Biological Assay;Biology;Brain;C26 tumor;Cachexia;Calcium;Cancer Cachexia;cancer cell;Cancer Cell Growth;Cancer Model;career;career development;Cells;Chronic;clinical candidate;Clinical Trials;clinically significant;Coculture Techniques;Colon Carcinoma;Colorectal Cancer;Cyclic AMP-Dependent Protein Kinases;cytokine;Data;Degenerative Disorder;Denervation;effective intervention;energy balance;Ensure;experience;experimental study;Fasting;Fiber;Foundations;FRAP1 gene;Functional disorder;Generations;Genetic;ghrelin;GHS-R1a;Glucocorticoids;Goals;Grant;hallmarks of aging;healthspan;Holly;Hormones;Human;Impairment;improved;in vivo;increased appetite;Incubated;Individual;Inflammation;Inflammatory;innovation;Insulin-Like Growth Factor I;Interferon Type II;Intervention;Laboratories;Lead;lean body mass;Learning;Malignant Epithelial Cell;Malignant Neoplasms;Measures;Medical Research;Mentors;Mentorship;Microfilaments;middle age;Mitochondria;Modeling;Modification;Molecular;Molecular Biology;Monitor;motor neuron function;Mus;Muscle;muscle aging;Muscle Fibers;muscle form;Muscle function;Muscle Weakness;Muscular Atrophy;Myoblasts;Myopathy;Nerve;Nerve Degeneration;nerve supply;neurogenesis;Neurons;novel;Obesity;Oklahoma;Oxidation-Reduction;Oxidative Stress Induction;Pathologic;Pathway interactions;Permeability;pharmacologic;Phase;Phosphorylation;Physiological;Physiology;Postdoctoral Fellow;precursor cell;prevent;Principal Investigator;PRKCA gene;Proliferating;Protein Biosynthesis;protein degradation;Protein Degradation Inhibition;Protein Kinase;Proteins;Quality of life;receptor;reduced muscle mass;Research;Role;Safety;sarcopenia;Secure;Signal Transduction;Skeletal Muscle;skeletal muscle wasting;skeletal muscle weakness;Somatotropin;success;synthetic peptide;systemic inflammatory response;Techniques;Testing;Thinness;TNF gene;Training;Translations;uptake;wasting;Wasting Syndrome;Wild Type Mouse

PROJECT_TITLE: The role of unacylated ghrelin on age-associated progressive muscle weakness and cachexia elicited by cancer


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related

PHR: PROJECT NARRATIVE This study will explore the specificity and function of the VNAR nanobody repertoire elicited by sarbecovirus and merbecovirus spike ferritin nanoparticle immunogens in nurse sharks. Combining binding studies, competition mapping assays, viral neutralization, and in vivo protection studies with high-resolution structural biology, we will utilize these shark nanobodies to provide extensive and detailed information on highly conserved, neutralizing viral epitopes. Such information is key for the design of new immunogens that will elicit pan-sarbecovirus and pan-merbecovirus protective immune responses.

PI_NAMEs: DOOLEY, HELEN M. (contact);JOYCE, MICHAEL GORDON

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 2019-nCoV;Affinity;Animals;Antibody Response;Antibody Specificity;Antigen-Antibody Complex;Antigens;B-Lymphocytes;Baltimore;betacoronavirus;Binding;Biological Assay;Blood;Clinical effectiveness;Collaborations;Controlled Clinical Trials;Coronavirus;coronavirus vaccination;COVID-19 pandemic;cross reactivity;Cryoelectron Microscopy;design;Development;Emerging Communicable Diseases;Epitopes;Etiology;Ferritin;Foundations;Future;future pandemic;General Population;Goals;Human;Humoral Immunities;Image;Immune;Immune response;Immunization;Immunize;immunogenic;Immunology;Immunotherapeutic agent;in vivo;innovation;Maps;Maryland;medical schools;Merbecovirus;Methods;Middle East Respiratory Syndrome Coronavirus;Molecular;molecular recognition;nanobodies;nanoparticle;Negative Staining;neutralizing antibody;next generation;novel;Nurses;pandemic potential;Phage Display;prevent pandemics;Proteins;Recombinants;Research;Research Institute;Resolution;response;Sarbecovirus;SARS coronavirus;SARS-CoV-2 spike protein;SARS-CoV-2 variant;Shark;Site;Specificity;spillover event;structural biology;Structure;Techniques;universal coronavirus vaccine;Universities;Vaccination;vaccination strategy;vaccine candidate;Vaccine Design;Vaccine Research;variants of concern;Viral;X-Ray Crystallography;zoonotic coronavirus;zoonotic spillover

PROJECT_TITLE: Shark nanobodies enable identification of pan-sarbecovirus and pan-merbecovirus spike RBD sites of vulnerability

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative This project will allow us to test neurobehavioral mechanisms of a mindfulness-based intervention to target mood lability in early adolescents at high risk for developing mood disorders. Mood lability is an important transdiagnostic problem that is associated with poor psychosocial function and suicidal thoughts, and is a predictor of mood disorder onset, especially in youth at familial risk. Through this randomized controlled trial, we will better understand how and for whom mindfulness interventions work, which will lead to more targeted interventions to improve emotion regulation during this key developmental period.

PI_NAMEs: HAFEMAN, DANELLA MARIE (contact)

PROGRAM_OFFICER_NAME: GARVEY, MARJORIE ANN

PROJECT_TERMS: 13 year old;Adolescence;Adolescent;Adult;Affective;Anxiety;Awareness;Behavioral;Behavioral Mechanisms;biological adaptation to stress;Bipolar Disorder;Child;Clinical;Clinical assessments;Data;design;Development;Diagnosis;Diagnostic;DSM-V;early adolescence;Ecological momentary assessment;Elements;emotion regulation;Emotions;Exercise;Family history of;Feeling suicidal;follow-up;Future;Goals;group intervention;high risk;Impairment;improved;Incidence;Individual;Intake;Intervention;Lead;Link;Literature;Measures;Mediating;Mental Depression;Meta-Analysis;Mind;mindfulness;mindfulness intervention;Modification;Mood Disorders;mood symptom;Moods;negative affect;neural;neural circuit;neurobehavioral;neurobehavioral test;Neuronal Plasticity;Onset of illness;Outcome;Parents;Participant;Patient Self-Report;personalized medicine;Pilot Projects;positive mood;post intervention;prevent;psychoeducation;psychosocial;Puberty;Randomized;Randomized, Controlled Trials;Reporting;Research Personnel;response;Rest;Risk;Sampling;Scanning;sex;Social Interaction;suicidal risk;sustained attention;Symptoms;Task Performances;Testing;therapy design;Thinking;Time;Work;Youth

PROJECT_TITLE: Neurobehavioral Targets of Mindfulness in Youth At Risk for Mood Disorders

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative: Overall The Oregon Alzheimer’s Disease Research Center creates a unique environment for research and discovery of new insights into healthy brain aging, transitions to Alzheimer’s, and for treatment and management of cognitive decline. This is facilitated by state-of the art clinical, biochemical, technological and statistical tools, subject and tissue resources, and data widely shared for maximum impact with the scientific community and appropriately translated to families and other key stakeholders.

PI_NAMEs: LIM, MIRANDA M;SILBERT, LISA C (contact)

PROGRAM_OFFICER_NAME: ELLIOTT, CERISE

PROJECT_TERMS: Address;Aged, 80 and over;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Behavior monitoring;Biochemical;Biological;Biological Markers;brain tissue;Clinical;Collaborations;collaborative environment;Communities;community engagement;Data;Dementia;Disease;Early Diagnosis;Education;education research;effective therapy;empowerment;Ensure;Environment;Family;Family member;Goals;Home;Impaired cognition;improved;Infrastructure;innovation;insight;interest;Knowledge;late life;meetings;Methods;multidisciplinary;neuroimaging;neuropathology;novel;Oregon;Participant;Patients;Peripheral;pre-clinical;prevent;programs;Research;Research Infrastructure;Research Support;Science;Scientist;Specimen;Technology;Testing;tissue resource;tool;Training and Education;Translating;volunteer

PROJECT_TITLE: Oregon Alzheimer's Disease Research Center


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: KAYE, JEFFREY A (contact)

PROJECT_TERMS: African American;Aged, 80 and over;Aging;aging brain;Alzheimer's Disease;Animal Welfare;Area;Behavior monitoring;Biological;Biological Assay;Biological Markers;brain tissue;Clinical;Clinical assessments;Clinical Research;Clinical Trials;Clinical Trials Unit;cohort;Collaborations;collaborative environment;Communities;Community Participation;community partners;cooperative study;Data;data management;data sharing;Dementia;Development;Disease;Education;Education and Outreach;education research;Ensure;Event;follow-up;Fostering;Goals;high standard;Home;human subject;Image;improved;Individual;Infrastructure;innovation;Institution;Knowledge;late life;Lead;Left;Link;Monitor;neuroimaging;neuropathology;novel;Oregon;outreach;Participant;Peripheral;Policies;pre-clinical;preservation;Productivity;programs;quality assurance;recruit;repository;Research;Research Design;Resources;Role;Science;Scientist;Side;Sister;Specimen;Standardization;statistics;Structure;Technology;Testing;Time;Tissues;Training and Education;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Telehealth

PI_NAMEs: PIERCE, AIMEE  (contact)

PROJECT_TERMS: African American;Aged, 80 and over;Aging;aging brain;aging in place;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Attention;Behavior monitoring;Biological;Biological Markers;Blood;brain tissue;career;Clinic;Clinical;Clinical assessments;Clinical Research;Clinical Trials;cohort;Collaborations;collaborative environment;Communities;computer generated;Computers;Conduct Clinical Trials;cooperative study;Data;data acquisition;data management;data sharing;Dementia;dementia risk;Development;digital;Digital biomarker;digital technology;Disease;DNA;Education;education research;Environment;follow-up;Fostering;Goals;Health;high risk;Home;Image;improved;Individual;Infrastructure;innovation;interest;Investigator-Initiated Research;Knowledge;late life;Liquid substance;Magnetic Resonance Imaging;Measures;Methods;Monitor;neuroimaging;neuroimaging marker;neuropathology;novel;Octogenarian;older adult;Oregon;Outcome;outreach;Participant;Peripheral;pharmacologic;Phase;Population;Positron-Emission Tomography;pre-clinical;prevent;Procedures;programs;recruit;remote monitoring;repository;Research;Research Activity;Research Design;Research Personnel;Research Subjects;Resources;Science;Scientist;sensor;Severity of illness;Sister;Sleep;Specimen;Standardization;statistics;Telemedicine;Testing;Tissues;tool;Training;Training and Education;volunteer;Work

PROJECT_TITLE: Clinical Core


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Substance Misuse

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

PHR: Project Narrative: The Partnership for Research in Implementation Science- Mozambique (PRISM), a collaboration between the Faculty of Medicine at University Eduardo Mondale (UEM) in Maputo, Mozambique and the Vanderbilt Institute for Global Health (VIGH) at Vanderbilt University Medical Center (VUMC), will build upon successes of its first five-year period to continue developing HIV implementation science research capacity at UEM. The present proposal has been developed jointly with the leadership of UEM to respond to their current desire to evolve the institution's pool of Master´s level researchers to the doctoral level, as well as continue further development of the newly created Implementation Science Unit formed to create new opportunities for the conduct of meaningful and high-quality HIV implementation science research at UEM at beyond.

PI_NAMEs: MOON, D. TROY (contact);SIDAT, MOHSIN

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Academic Medical Centers;Adult;Africa;aged;Award;Clinic;cohort;Collaborations;Communities;Country;Doctor of Philosophy;Economics;Epidemiology;experience;Faculty;Fellowship;Foundations;global health;Government;Graduate Education;Growth;Health;health care service;Health education;Health Services Research;HIV;HIV/AIDS;Human;Human Development;implementation science;improved;indexing;Infrastructure;innovation;Institution;International;Investments;Medical Research;medical schools;Medicine;Mozambique;Ownership;Persons;Portuguese;Prevalence;Professional Education;programs;Public Health;Research;Research Personnel;Resources;response;Science;Scientist;service delivery;Site;stem;Training;Universities;War

PROJECT_TITLE: UEM-Partnership for Research in Implementation Science Mozambique (PRISM).