ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Data Science;Disability Research;Hearing Loss

ORG_DEPT: MISCELLANEOUS

PHR: Deaf and Hard of Hearing DHH persons are highly underrepresented in the research community, making up less than 1% of STEM Doctorate recipients. To address this disparity, the University of Pittsburgh (Pitt) and Gallaudet University (GU) will partner to create the Accessible and Inclusive Biomedical Informatics and Data Science (AIBIDS) program which is unique for its focus on empowering both DHH students and persons from other underrepresented groups in the sciences to lead biomedical informatics and data science research. The program will increase the inclusion and accessibility of biomedical informatics and data science research through authentic, accessible, and inclusive mentored research internships with experienced faculty and near- peer mentors to a highly diverse group of undergraduate and Masters level students.

PI_NAMEs: ARORA, GAURAV SURESHKUMAR;BOYCE, RICHARD DAVID (contact)

PROJECT_TERMS: Academia;Academic support;Address;Adult;American Sign Language;Area;Awareness;Bilateral;bilingualism;Biological Sciences;Biology;biomedical informatics;career;Collaborations;Communities;Complement;computer science;Country;Data;Data Science;deaf;Development;Disparity;Doctor of Philosophy;Educational Activities;educational atmosphere;Educational Curriculum;Educational process of instructing;empowerment;Engineering;Evaluation;experience;Faculty;Funding;Future;hard of hearing;Health;Hearing;high school;High School Student;Human;Individual;Industry;Informatics;informatics training;Internships;Language;language training;Lead;Mathematics;Measures;Mentors;Mentorship;Methods;next generation;novel;peer;peer coaching;Perception;Persons;physical science;programs;Public Health;Publishing;Research;Science;Scientist;Site;student participation;Students;summer internship;symposium;Technology;Training Programs;undergraduate student;Underrepresented Populations;Underrepresented Students;United States;Universities;Woman;Work

PROJECT_TITLE: Building Accessible and Inclusive Paths for Students in Biomedical Informatics and Data Science


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Biotechnology;Genetics;Women's Health Research

ORG_CITY: NOVATO

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

ORG_STATE: CA

PHR: PROJECT NARRATIVE We will determine the feasibility of detecting senescent cells in two distinct tissues – the ovary and the vasculature using novel technologies. We will evaluate molecular markers of cellular senescence in single cells and biofluids using a combination of gene and protein expression, and secreted proteins. If successful in our initial pilots, we will validate our approaches in human biopsies, demonstrating broad clinical utility of these emerging technologies.

PI_NAMEs: DUNCAN, FRANCESCA E.;MELOV, SIMON  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Abdomen;Affect;Age;Age related pathologies;aged;Aging;Antibodies;antibody conjugate;Aorta;arteriole;Back;Biological;biological adaptation to stress;Biological Markers;Biological Models;Biology;biomarker identification;biomarker validation;Biopsy;Blood Vessels;Bystander Effect;CDKN2A gene;Cell Aging;Cell Culture Techniques;Cell Nucleus;Cell Proliferation;Cell surface;cell type;Cells;Characteristics;chemokine;Chronology;Clinical;Communities;comparative;Complex;contrast enhanced;cytokine;Data;design;Detection;Development;digital;Disease;Doxorubicin;Embryonic Development;Emerging Technologies;Explosion;Fatty acid glycerol esters;Frequencies;Gene Combinations;Gene Expression;Gene Expression Profiling;Genetic;Genetic Transcription;Genotype;Goals;Growth Factor;high risk;Human;human subject;human tissue;improved;in vivo;Inflammatory;Injections;innovative technologies;Lipids;Location;Mainstreaming;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Measurable;Microbubbles;Microfluidics;Modeling;molecular marker;Molecular Profiling;Morphology;mouse model;Mus;Muscle;Muscle Fibers;nano-string;Nature;Nerve Degeneration;new technology;novel;old mice;Ovarian;Ovarian aging;Ovarian Tissue;Ovary;Peptide Hydrolases;Pharmaceutical Preparations;Phase;Phenotype;Physiological;Pilot Projects;prevent;Production;protein expression;Protein Secretion;Research Personnel;response;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Sensitivity and Specificity;Skeletal Muscle;small molecule;Structure;Techniques;Technology;Therapeutic;Time;Tissues;transcriptomic profiling;Ultrasonography;ultrasound;Validation;Variant;Visualization;whole genome

PROJECT_TITLE: Evaluating diverse technologies for detecting and validating senescent cells in vivo

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(70)R]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE - OVERALL The Cervical Cancer Prevention Partnership (C2P2) program is a collaboration between investigators in the US (Seattle), Peru (Lima) and the Dominican Republic (Santo Domingo). It has the following goals: 1) building strong and collaborative partnerships – both among investigators at these sites and between site investigators and the National Cancer Institute, and 2) conducting trials in Peru and the Dominican Republic to address the cervical cancer prevention and treatment needs of HIV-infected populations.

PI_NAMEs: CABELLO, ROBINSON ;DESCHAMPS, MARIE MARCELLE H.;DONASTORG, YEYCY A.;DUERR, ANN C;MADELEINE, MARGARET M (contact)

PROGRAM_OFFICER_NAME: FRECH, MARIA SILVINA

PROJECT_TERMS: Acceleration;Address;Algorithms;B-Lymphocytes;Biological Assay;Cancer Burden;Cancer Etiology;cancer prevention;cancer therapy;Caribbean region;Caring;cervical cancer prevention;Cessation of life;Child;Clinic;Clinical;Clinical Trials;Collaborations;Collection;Communication;cost;Country;data management;Dedications;design;Diagnosis;Dominican Republic;Dose;effectiveness testing;Ensure;experience;Future;Future Generations;General Population;Goals;HIV;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;immunogenicity;Immunotherapy;improved;Incidence;Infrastructure;Interruption;Laboratories;Latin America;Lesion;low and middle-income countries;Malignant neoplasm of cervix uteri;Minority;Modeling;Monitor;mortality;National Cancer Institute;new technology;novel;novel strategies;Persons;Peru;Population;premalignant;Prevention;Prevention approach;Prevention strategy;Primary Care;Primary Prevention;Productivity;programs;Protocols documentation;Provider;Quality Control;recruit;Regimen;Research Personnel;Resource-limited setting;Resources;response;Safety;Sampling;Schedule;screening;Site;Statistical Data Interpretation;statistics;success;Time;Training;treatment strategy;Triage;Vaccination;Vaccines;Visit;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Colaboracion Evita: HPV-Related Cancer Prevention Partnership Center


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;HPV and/or Cervical Cancer Vaccines;Immunization;Infectious Diseases;Patient Safety;Pediatric;Pediatric - AIDS;Prevention;Rare Diseases;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

PI_NAMEs: MADELEINE, MARGARET M (contact)

PROJECT_TERMS: Acceleration;Accountability;Adoption;Advocate;Biological Assay;Cancer Burden;cancer prevention;cancer risk;Caribbean region;cervical cancer prevention;Cessation of life;Child;CLC Gene;Clinical;Clinical Services;Clinical Trials;co-clinical trial;Communication;community partners;Country;Credentialing;Data;data management;Disproportionately impacts women;Dominican Republic;experience;Fostering;Goals;Grant;Guidelines;Heart;HIV;Human papilloma virus infection;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;human subject;improved;Income;Information Dissemination;Infrastructure;Institution;International;Interruption;Laboratories;Laboratory Procedures;Latin American;Lead;Leadership;Lesion;Malignant neoplasm of cervix uteri;meetings;member;Methods;Modeling;Monitor;novel strategies;Outcome;Paper;participant safety;patient safety;Periodicals;Persons;Peru;Policies;Population;premalignant;prevent;Preventative vaccination;Prevention;Primary Prevention;Problem Solving;Productivity;Protocols documentation;Publications;Publishing;Qualifying;Quality Control;Records;recruit;Reporting;Research;Research Personnel;Resources;Risk;Safety;Schedule;Science;Scientific Advances and Accomplishments;screening;Secondary Prevention;Services;Site;skills training;Structure;success;tertiary prevention;tool;Training;Translating;Triage;Update;Vaccination;Woman;Work

PROJECT_TITLE: Administrative and Coordinating Core


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Prevention;Unintentional Childhood Injury

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Novice drivers share a disproportionate amount of crash risk compared to experienced drivers, which is thought to be largely driven by teens’ inexperience in identifying potential hazards on the roadway. Parents serve as the primary instructor of teens’ driving under the learner phase of licensure, yet existing literature indicates that parents do not regularly engage in instruction on how to anticipate and respond to potential roadway hazards. This research will address priorities set forth by NICHD to access and prevent traumatic injuries by improving parental instruction of teens’ ability to anticipate hazards on the roadway via a parent- focused teen-driving intervention.

PI_NAMEs: O'NEAL, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: Abbreviations;adaptive learning;Address;Adult;Automobile Driving;Award;Child;Child Rearing;Cognition;Communication;comparison control;Complex;Control Groups;design;Detection;Development;Discipline;distracted driving;Drops;Educational Intervention;Educational process of instructing;Engineering;Environment;Evaluation;Event;evidence base;Evidence based intervention;Exhibits;experience;Exposure to;Failure;Family;feasibility testing;Feedback;Fellowship;Future;Goals;hazard;Hazard Identification;improved;Individual Differences;injury prevention;Instruction;instructor;Interdisciplinary Study;Intervention;Learning;Learning Module;Licensure;Literature;National Institute of Child Health and Human Development;Online Systems;parent-child communication;parenting intervention;Parents;Pattern;Perception;Phase;Population;Positioning Attribute;Postdoctoral Fellow;prevent;Prevention;preventive intervention;Primary Prevention;Problem behavior;programs;Psychology;Public Health;Reaction;Research;response;Risk;Risk Taking;Running;scaffold;simulation;skills;Speed;Strategic Planning;Supervision;teacher;teen drivers;teen driving;Teenagers;Temperament;Testing;therapy development;Training;Training Programs;Translational Research;Traumatic injury;Vehicle crash;Vulnerable Populations;Work

PROJECT_TITLE: Improving Novice Driver Roadway Hazard Identification Through a Parent-Focused Intervention

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: TR

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: WASHINGTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative MELAS and LHON-Plus are two devastating and fatal mitochondrial neurodegenerative disease for which there is no effective treatment. The proposed clinical trial focuses on our new pharmacological strategy targeting epigenomics and mitochondrial metabolism that will tested in our cohort of MELAS and LHON-Plus patients. We anticipate that our results will advance the therapeutic field of these maternally inherited mitochondrial diseases to address the umet medical needs of these patients.

PI_NAMEs: CHIARAMELLO, ANNE ELIANE (contact);REGIER, DEBRA S

PROGRAM_OFFICER_NAME: BROOKS, PJ

PROJECT_TERMS: Address;Adult;Affect;American;Animal Model;Animals;arm;ATP Synthesis Pathway;Biological Assay;Butyrates;Butyric Acids;Bypass;Cell model;Cessation of life;Child;Childhood;Chronic;Clinical;Clinical and Translational Science Awards;clinical heterogeneity;clinical phenotype;Clinical Research;Clinical Trials;Clinical Trials Design;cohort;Complex;Data Set;design;Diffusion;disability;Disease;disease-causing mutation;Dose;Drug Kinetics;drug withdrawal;effective therapy;Enrollment;epigenomics;Etiology;Exhibits;fatty acid oxidation;FDA approved;Fibroblasts;Funding;Future;Gene Expression;HDAC4 gene;Health Sciences;Histone Acetylation;Histone Deacetylase Inhibitor;improved;Individual;Infrastructure;Inherited;innovation;Lead;Leber's Hereditary Optic Neuropathy;Lipase;Medical;Medical center;medical schools;MELAS Syndrome;Metabolism;Mitochondria;Mitochondrial Diseases;mitochondrial metabolism;Molecular;Molecular Target;Morbidity - disease rate;National Cancer Institute;Neurodegenerative Disorders;Neurologic;novel;novel therapeutics;Nuclear;open label;Outcome;Output;Oxidative Phosphorylation;participant enrollment;patient population;patient response;Patients;personalized medicine;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacologic Substance;Pharmacology Study;Phase;Population;pre-clinical;pre-Investigational New Drug meeting;preclinical study;preclinical trial;premature;Prevalence;Prodrugs;programs;Property;Protocols documentation;Rare Diseases;Recovery;recruit;Research Personnel;respiratory;response;Safety;safety study;Site;Sodium Butyrate;Symptoms;targeted therapy trials;Testing;Therapeutic;therapeutic candidate;Therapeutic Intervention;therapeutically effective;Toxic effect;tributyrin;United States National Institutes of Health;Universities;Volatile Fatty Acids;Washington

PROJECT_TITLE: Emerging therapeutic candidates for rare maternally inherited mitochondrial diseases with shared etiologies


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: CHICAGO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Tuberculosis(TB), caused by the organism M.tuberculosis (Mtb) kills ~1.5 million people worldwide every year. The goal of this project is to identify novel ways to improve IL-17 and Th17 vaccine-induced cells to provide sterilizing vaccine-induced immunity against TB. The relevance of this work to public health is that it will significantly impact the design of future vaccine strategies by allowing us to target Th17 responses to improve TB vaccines, and will therefore have the potential to reduce the global incidence of TB.

PI_NAMEs: KHADER, SHABAANA A. (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acceleration;Adjuvant;Agonist;Anti-Inflammatory Agents;Antigen-Presenting Cells;B-Cell Activation;Bacille Calmette-Guerin vaccination;BCG Vaccine;Binding;BLR1 gene;C Type Lectin Receptors;CD4 Positive T Lymphocytes;Cell Physiology;Cell Therapy;Cells;Cessation of life;chemokine;Collaborations;CXCL13 gene;cytokine;Data;Dendritic cell activation;Dendritic Cells;design;Development;Early identification;Enhancers;Epithelial Cells;extensive drug resistance;Funding;Future;Goals;Grant;Granulocyte-Macrophage Colony-Stimulating Factor;Growth;Helper-Inducer T-Lymphocyte;Human;IL17 gene;Immune response;Immunity;improved;Incidence;Individual;Inflammatory;Interferon Type II;Interleukin-10;interleukin-10 receptor;interleukin-23;Light;Lung;Lymphoid Follicle;Macrophage;Maintenance;Mediating;Molecular;Montana;mucosal vaccination;Mucous Membrane;Multiple drug resistant Mycobacteria Tuberculosis;Mus;Mycobacterium bovis;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;Myeloid Cell Activation;novel;Nuclear;Organism;overexpression;Pathway interactions;Persons;Population;Production;Proliferating;Public Health;Pulmonary Tuberculosis;receptor;receptor function;Receptor Signaling;resistant strain;response;Role;Signal Transduction;Subunit Vaccines;T-Lymphocyte;Testing;Th1 Cells;translational medicine;Tuberculosis;tuberculosis immunity;Tuberculosis Vaccines;Universities;Vaccinated;vaccine efficacy;vaccine immunogenicity;vaccine response;vaccine strategy;vaccine-induced immunity;Vaccines;Work

PROJECT_TITLE: Role of IL-17 in Protective Vaccine-induced Immune Responses Against Tuberculosis

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Columbus

ORG_DEPT: GENETICS

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Narrative: The goal of this proposal aims at understanding how two key cell signaling enzymes including protein kinase S6K1 and heteromeric phosphatase PP2A are regulated by specific posttranslational modifications (PTMs) and other allosteric mechanisms. Dysregulation of S6K1 and PP2A by changes in PTMs has been associated with devastating human diseases such as cancer, diabetes, obesity, and neurodegenerative diseases. New protein semisynthesis approaches will be developed and used to define the functions of these PTMs, and our findings will offer mechanistic insights to modulate the activity of these signaling enzymes for disease treatment.

PI_NAMEs: CHU, NAM KY (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: analog;Binding;Biological Assay;C-terminal;Calibration;Cell Physiology;Cells;Chemicals;combat;Complex;crosslink;Diabetes Mellitus;Disease;Enzymes;Equilibrium;Eukaryotic Cell;FRAP1 gene;Goals;human disease;insight;interest;Kinetics;Link;Malignant Neoplasms;Measurement;Methods;Methylation;Molecular;nanobodies;Neurodegenerative Disorders;novel;novel therapeutic intervention;Obesity;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Play;Portraits;Post-Translational Protein Processing;Protein Kinase;Protein phosphatase;Protein Phosphatase 2A Regulatory Subunit PR53;Proteins;recruit;Regulation;response;Signal Pathway;Signal Transduction;Site;Stimulus;Structure

PROJECT_TITLE: Chemoenzymatic Protein Semisynthesis Approaches Toward Cell Signaling Enzymes


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Prevention;Women's Health Research

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Drug-induced torsades de pointes (TdP) is an irregular heartbeat that results in catastrophic outcomes, including sudden cardiac death. Older patients are at greater risk for drug-induced TdP, due to declining blood levels of progesterone (postmenopausal women) and testosterone (older men). This research will determine if administration of progesterone (to postmenopausal women) or testosterone (to older men) diminishes drug- induced lengthening of an EKG measurement known as the QT interval, which is associated with TdP risk, and will be the first to identify an effective therapy for reducing the risk of this irregular heartbeat in high risk patients.

PI_NAMEs: TISDALE, JAMES E. (contact)

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: Age;Age Years;Anti-Arrhythmia Agents;anti-depressive agents;Antibiotics;antimicrobial;Antipsychotic Agents;Area;Arrhythmia;Attenuated;attenuation;Biological Markers;Blood;Cardiac;Cardiac Electrophysiologic Techniques;cardiovascular pharmacology;Clinical;Clinical Trials;Cross-Over Studies;Data;Dose;Double-Blind Method;Drug usage;effective therapy;efficacy evaluation;Electrocardiogram;experience;Fluoroquinolones;Goals;Gonadal Steroid Hormones;Heart Rate;high risk;high risk population;Hormones;human old age (65+);ibutilide;improved;Macrolides;Measurement;medication safety;men;Methadone;Methods;multidisciplinary;novel;novel strategies;novel therapeutic intervention;older men;older patient;older women;Oral;Oral Administration;Outcome;Outcome Measure;Patients;Pharmaceutical Preparations;Pharmacists;Pharmacodynamics;Phase;Placebo Control;Placebos;Postmenopause;pre-clinical;Prevention;Prevention strategy;Preventive;primary outcome;Progesterone;prospective;protective effect;Publishing;Randomized;Research;Research Personnel;response;Risk;Risk Factors;Risk Reduction;Scientist;Serum;sudden cardiac death;Testing;Testosterone;time interval;Torsades de Pointes;Ventricular;Ventricular Arrhythmia;Ventricular Tachycardia;Woman;Work

PROJECT_TITLE: Novel Approaches for Minimizing Drug-Induced QT Interval Lengthening

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE This study will make a substantial contribution towards improving our understanding of the expression and function of imprinted genes in the brain and the genetic and cellular mechanisms controlling complex behavior. The proposed research is relevant to public health because it could lead to improvements in our ability to evaluate genetic risk factors for mental illness according to whether mutations are maternally or paternally derived and uncover therapeutic strategies to help improve behavioral pathologies.

PI_NAMEs: GREGG, CHRIS  (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: Adrenal Glands;Adrenal Medulla;Affect;Alleles;Behavior;Behavior Control;Behavior Disorders;behavior test;Behavioral;Behavioral Model;behavioral phenotyping;behavioral response;Biological Assay;Brain;brain cell;Brain region;Catecholamines;cell type;Cells;Complex;Decision Making;Dependovirus;DOPA decarboxylase;Enzymes;Epigenetic Process;Epinephrine;Exhibits;Fasting;Female;Genes;Genetic;Genetic Models;genetic risk factor;genetic variant;Genomic Imprinting;Goals;Heritability;Heterozygote;Human;Hydrocortisone;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;imprint;improved;Length;Link;machine learning method;male;Mammals;maternal imprint;Mental disorders;Metabolic;Methods;Modeling;monoamine;Mus;Mutant Strains Mice;Mutation;Nature;Neurons;novel;offspring;parental involvement;Parents;paternal imprint;Pathology;Pattern;Population;Population Control;Process;Public Health;Publishing;Reporter;Reproducibility;Research;Resources;Rewards;Risk;Role;Serotonin;sex;Stress;stressor;targeted treatment;Testing;Therapeutic;Tissues;Tyrosine 3-Monooxygenase;unsupervised learning

PROJECT_TITLE: The Nature and Function of Genomic Imprinting in Monoaminergic Neurons

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative Aortic stiffness increases markedly with age, particularly after midlife, and is associated with high blood pressure, reduced pumping and filling of the heart, faster brain aging and impaired memory. Abnormal coupling between left ventricle and aorta contributes to pathogenesis of target organ damage particularly heart failure (HF). This is the first ever study to assess the vascular interaction with cardiac structure / function / mechanics in a population-based cohort of Hispanics, incorporating comprehensive pressure-flow vascular measurements to complement cardiac structure and function assessments including myocardial speckle tracking analyses. The proposed research leverages multiple existing NIH resources and is highly relevant to public health because of the elevated HF risk profile of Hispanics. Assessment of vascular function concomitant with cardiac parameters in Hispanics will add to the HF risk prediction model, improve the conceptual framework of HF risk and provide insight into future strategies to prevent or delay HF in this high-risk segment of the population by preventing or improving abnormal vascular function. Identification of Hispanics with abnormal vascular function will help to differentiate those with asymptomatic diastolic dysfunction who are at the highest risk for progression to HF and other adverse events. In addition, we propose the opportunity for a pooled cohort analysis of vascular function across African-Americans, Hispanic and Caucasians making our project highly relevant to NIH’s mission of Big Data to Knowledge research priority initiatives, establishing a large vascular data repository resource for future collaboration. Lastly, the proposed research also represents a novel approach to uncovering latent longitudinal patterns of changes in cardiac phenotypes to identify subpopulations with high-risk for progression to clinical HF. Investigation into these aforementioned important areas will be extremely promising in learning about Hispanic cardiovascular health and highly relevant to future public health planning.

PI_NAMEs: RODRIGUEZ, CARLOS JOSE (contact)

PROGRAM_OFFICER_NAME: KUNZ, JOHN FREDERIC

PROJECT_TERMS: Acceleration;Acculturation;Address;Adverse event;Affect;African American;African American population;Age;aging brain;Ancillary Study;Aorta;Area;Big Data to Knowledge;biracial;Black Populations;Blood Vessels;brachial artery;Cardiac;Cardiac Output;cardiovascular health;Cardiovascular system;Carotid Arteries;Caucasians;Characteristics;Clinical;clinical risk;Clinical Trials;cohort;Cohort Analysis;Collaborations;Color;Communities;comorbidity;Complement;cost effective;Coupled;Coupling;Data;data repository;Data Set;design;Development;Diabetes Mellitus;Dilatation - action;Disparity;Early identification;Echocardiography;electric impedance;Endothelium;ethnic difference;ethnic minority;femoral artery;Femur;follow-up;Framingham Heart Study;Functional disorder;Funding;Future;Goals;Health;health disparity;Health Planning;Heart;Heart Abnormalities;Heart failure;heart imaging;hemodynamics;high risk;Hispanic;Hispanic Community Health Study/Study of Latinos;Hispanic Populations;Hypertension;Impairment;improved;Incidence;Infrastructure;innovation;insight;Intervention;Investigation;Jackson Heart Study;Latino Population;Learning;Left;Left atrial structure;Left Ventricular Ejection Fraction;Left Ventricular Mass;Left ventricular structure;Link;Measurement;Measures;Mechanics;Mediating;Memory impairment;middle age;Mission;Monitor;mortality;Myocardial;Myocardial dysfunction;National Heart, Lung, and Blood Institute;next generation;Not Hispanic or Latino;novel strategies;Obesity;Organ;Outcome;Parents;Participant;Pathogenesis;Patient Care;Patients;Pattern;Persons;Phenotype;Physiologic pulse;Population;population based;Predisposition;preservation;pressure;Prevalence;prevent;progression risk;psychosocial;Public Health;Publishing;pulmonary arterial pressure;Pulse Pressure;Pump;racial difference;racial minority;radial artery;Relaxation;Research;Research Priority;Resistance;Resources;Right ventricular structure;Risk;Risk Factors;risk prediction model;Role;screening;Signal Transduction;social culture;Social Discrimination;Social isolation;sociodemographics;Socioeconomic Status;Statistical Methods;Stroke Volume;Structure;Study of Latinos;System;Testing;Tissues;Underrepresented Populations;United States;United States National Institutes of Health;unnecessary treatment;vascular abnormality;Vascular Diseases;Vascular System;Ventricular;Vulnerable Populations;Work

PROJECT_TITLE: Vascular Determinants of Stage B HF among Hispanics: the role of the Heart-Vascular Interaction

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: LOUISVILLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: This proposal aims to gather a better understanding of gastroparesis which is a devastating disorder in predominantaly younger women. This is a continuation of the Gastroparesis Clinical Research Consortium (GpCRC). The GpCRC has made a series of important contributions to improve our understanding of this disorder and advancing the goals of patients, physicians and the NIH for management of gastroparesis.

PI_NAMEs: ABELL, THOMAS LYMAN (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Abdominal Pain;Affect;Age;Anatomy;Autoimmune;Botulinum Toxins;Caring;Characteristics;Chronic;Clinical;clinical center;Clinical Research;Databases;Devices;Digestive System Disorders;Disease;early satiety;effective therapy;Electric Stimulation;Electrolytes;Enrollment;Esophagus;Ethnic Origin;Etiology;evidence base;Feces;frailty;Functional disorder;Gastric Emptying;Gastrointestinal Diseases;gastrointestinal function;Gastroparesis;Gender;Genomics;Goals;gut-brain axis;Health;Health Services Accessibility;Homeostasis;Hormonal;improved;Inflammatory;Intervention Studies;Invisible disability;Knowledge;Learning;Life;Liquid substance;Malnutrition;Maps;Measures;metabolomics;Methods;Microanatomy;Mission;Motor;Motor Activity;motor disorder;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;Nausea;Nausea and Vomiting;neuromuscular;Nortriptyline;novel;novel strategies;nutrition;Nutritional Requirements;Nutritional status;Nutritional Support;Outcome;Pain;Pathogenesis;Patient-Focused Outcomes;Patients;Peripheral;persistent symptom;Pharmacology Study;Physical Function;Physicians;Physiological;Physiology;Protocols documentation;psychologic;Psychological Impact;Publishing;Quality of life;Questionnaires;Race;Randomized;Recommendation;recruit;Registries;Research;Resolution;response;Sensory;Series;Severities;Signal Transduction;Social isolation;Stomach;Symptoms;Syndrome;Therapeutic;therapeutically effective;Tissue Sample;treatment strategy;United States National Institutes of Health;Visceral;Vomiting;Weight;Work;young woman

PROJECT_TITLE: U of L Clinical Center to Investigate the Pathogenesis, Etiology, and Treatment of Gastroparesis through the NIDDK Gastroparesis Consortium


ADMINISTERING_IC: NS

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric

ORG_CITY: ANN ARBOR

ORG_NAME: BACKYARD BRAINS, INC.

ORG_STATE: MI

PHR: PROJECT NARRATIVE Backyard Brains is developing educational neurorobots: engaging and affordable robots with software running artificial, but biologically-inspired models of brains based on the latest neuroscience research. The robots and associated curriculum will enable students to understand principles of computational modeling as they create artificial brains that make the robots’ behavior life-like, sensory-guided and goal-directed. By giving teachers and students access to neurorobotic technologies previously only available in research labs, we aim to inspire the next generation of scientists, physicians and engineers.

PI_NAMEs: GAGE, GREGORY JOHN (contact);HARRIS, CHRISTOPHER AIDAN

PROGRAM_OFFICER_NAME: AUBRECHT, TARYN GRACE

PROJECT_TERMS: Address;Adopted;Affect;Architecture;base;Behavior;Belief;Biological;Biological Models;Biology;Brain;brain based;Brain Diseases;cloud based;Code;commercial application;commercialization;Communities;computational neuroscience;Computer Models;Computer Simulation;Computer software;Computers;Conceptions;cost;Dedications;design;Development;disadvantaged student;Ear;Education;Educational Curriculum;Educational process of instructing;Educational workshop;effective therapy;Electrophysiology (science);Engineering;Ensure;Equipment;Evaluation;Exercise;experience;Experimental Designs;Eye;Faculty Workshop;Family;fascinate;Feedback;Future Teacher;Goals;Growth;handheld mobile device;high school;High School Student;higher education;improved;Individual;innovation;inquiry-based learning;Institution;Investigation;K-12 Faculty;laptop;Learning;Life;Marketing;Mathematics;Medicine;Mentored Clinical Scientist Development Program;microphone;Mind;Modeling;Modernization;Motor;multidisciplinary;Nervous System;neural network;Neurosciences;Neurosciences Research;next generation;Next Generation Science Standards;Outcome;Phase;Philosophy;Physicians;Policy Maker;Population;Price;Production;project-based learning;prototype;Psychology;Reaction;Recurrence;Research;Research Personnel;Resources;Robot;Robotics;Running;Schools;Science;science museum;Scientist;Secondary Schools;Self Concept;Self Efficacy;Sensory;student participation;Students;success;System;teacher;Teacher Professional Development;Technology;tool;Training;Universities;wireless fidelity;World Health Organization;Writing

PROJECT_TITLE: Introducing Neuroscience and Neurocomputation Concepts to High School Students using Brain-based Neurorobots


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Narrative Humans use what they see to guide most of their movements. The relevant neural circuits involve all levels of the brain, from cortex to motoneurons. A better understanding of the operation of complete sensory-motor circuits will be important for improving human health in cases of stroke, neuro-degenerative motor disease, and developmental motor disorders.

PI_NAMEs: LISBERGER, STEPHEN G (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Address;Affect;Anatomy;Architecture;Area;area MT;Back;Behavior;Brain;Brain region;Brain Stem;Cell Nucleus;Cerebellum;Cerebral cortex;Chronic;Complement;Complex;Data;Development;Electric Stimulation;Electrodes;Elements;Evolution;expectation;experimental study;extrastriate;extrastriate visual cortex;Eye Movements;Feedback;Frequencies;frontal eye fields;Goals;Health;Human;Implant;improved;information organization;Inherited;Investigation;Knowledge;Learning;Measures;Mediating;Motion;Motor;motor behavior;motor control;Motor Cortex;motor disorder;Motor Neurons;Movement;MT3 gene;Nature;Nerve Degeneration;neural;neural circuit;Neural Pathways;neuromechanism;Neurons;Neurosciences;Noise;nonhuman primate;nucleus reticularis;operation;Output;Pathway interactions;Physiologic pulse;Physiology;Pontine structure;Population;Preparation;Property;Purkinje Cells;Ramp;Recurrence;response;sample fixation;sensorimotor system;Sensory;Signal Transduction;Site;Skeleton;Smooth Pursuit;Source;Speed;Stream;Stroke;Structure;System;Testing;Time;transmission process;Update;Variant;Visual;visual control;Visual Motion;visual motor;visual processing;Work

PROJECT_TITLE: Neural mechanisms of visual-motor control in smooth pursuit eye movement

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Immunotherapy;Radiation Oncology;Women's Health Research

ORG_CITY: Los Angeles

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE While immune-stimulating effects of radiation therapy have been recognized, how it works and how it can be enhanced remain to be elucidated. This proposal aims to investigate the therapeutic efficacy of a novel combinatorial treatment involving intratumoral immunotherapy and radiation, and understand the interaction between radiation and the host immune response using preclinical models and clinical samples. This project is expected to advance our knowledge of combining radiation therapy with immunotherapy and make significant contributions to cancer treatment.

PI_NAMEs: ITO, FUMITO  (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: Abscopal effect;adaptive immune response;Affect;Agonist;Anti-CD40;anti-PD-1/PD-L1;anti-PD-L1 antibodies;anti-PD-L1 therapy;Antigen Presentation;Antigens;Bilateral;Breast Melanoma;cancer cell;cancer infiltrating T cells;cancer therapy;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Cessation of life;Clinical;Clonal Expansion;combinatorial;Contralateral;Cross Presentation;cytotoxic;Data;Dendritic Cells;Development;Distant;Distant Metastasis;draining lymph node;effective therapy;Event;FLT3 gene;Foundations;Future;Human;Immune;Immune checkpoint inhibitor;Immune response;Immune system;Immunity;immunogenic;immunogenicity;Immunologic Memory;Immunologic Stimulation;Immunologics;immunoregulation;Immunotherapy;improved;In complete remission;In Situ;in vivo;Infiltration;insight;interest;Investigation;Knowledge;Lesion;Ligands;Lung;Lymphoid;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Metastatic breast cancer;Metastatic malignant neoplasm to brain;Modeling;mouse model;Mus;Myelogenous;Neoplasm Metastasis;neoplastic cell;novel;Outcome;Patients;PD-1/PD-L1;peripheral blood;Phenotype;Poly I-C;Pre-Clinical Model;Primary Neoplasm;Property;Radiation;radiation effect;Radiation therapy;Radioimmunotherapy;Refractory;Regimen;Research;Resistance;response;Role;Sampling;Shapes;single-cell RNA sequencing;Solid;stem;subcutaneous;T cell infiltration;T cell receptor repertoire sequencing;T cell response;T-cell inflamed;T-cell receptor repertoire;T-Lymphocyte;targeted treatment;Testing;Therapeutic;TLR3 gene;TNFRSF5 gene;trafficking;Treatment Efficacy;tumor;Tumor Antigens;tumor eradication;Tumor Immunity;tumor initiation;tumor microenvironment;tumor-immune system interactions;Unresectable;Work

PROJECT_TITLE: In situ radioimmunotherapy to maximize the engagement of conventional type 1 dendritic cells against non-T cell-inflamed tumors

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative. Lung transplantation is a well-established surgical intervention in advanced stages of the disease. Despite improvements in surgical procedures and immunosuppressive therapeutics, the median survival rate of the transplanted lung continues to be approx. 6 years. Chronic rejection of the transplanted lung is the most important obstacle to its long-term survival. Current state of-the-art reference technique for detecting chronic rejection is histopathological grading of transbronchial biopsies (TBBs). However, this is a highly invasive technique with several limitations, such as bleeding, inconsistent outcomes, and detection at advanced stages of the disease. Therefore, molecular imaging agent capable of allowing non-invasive assessment of chronic rejection after transplantation is a highly desirable diagnostic tool in nuclear medicine yet continues to be an unmet need. To accomplish this objective, this project is focused upon advancing the lead PET tracer further from preclinical development phase to prepare data for regulatory approvals and simultaneously assess its potential to image chronic rejection of the transplanted lung in mouse models at earlier stages. Of note, this project builds on pilot promising data with the new probe in mouse lung transplant model and human specimens. It is anticipated that successful accomplishment of proposed aims could deliver data for translation of a new PET molecular imaging agent for assessment of acute lung injury through first human studies, and a versatile noninvasive tool for stratification of patients with a risk factor for developing chronic lung allograft dysfunction thus nudging lung transplantation landscape towards image-guided pulmonary medicine.

PI_NAMEs: GELMAN, ANDREW ERIC;SHARMA, VIJAY  (contact)

PROGRAM_OFFICER_NAME: CHARYA, ANANTH VELUGALETI

PROJECT_TERMS: A549;Acute;Acute Lung Injury;Aging;Air;Allografting;alveolar epithelium;Alveolar Macrophages;Alzheimer's Disease;Apoptosis;Asthma;Atherosclerosis;Biochemical;Biodistribution;Biopsy;Blood Vessels;Bronchoalveolar Lavage;Bronchoalveolar Lavage Fluid;Cardiovascular Diseases;Cell Culture Techniques;Cell Fractionation;Cell Line;Cells;Characteristics;Chronic;Chronic Disease;Chronic lung disease;circulating biomarkers;cohort;Data;Detection;detection method;Development;Dexrazoxane;Diabetes Mellitus;Diagnosis;Diagnostic;diagnostic tool;Diameter;Discipline of Nuclear Medicine;Disease;DNA;Dose;dosimetry;drug efficacy;Drug Kinetics;Early Diagnosis;Epithelial Cells;Exhalation;Female;fibrotic lung disease;first-in-human;Flow Cytometry;Fluorescence;fluorescence imaging;Fluorescent Dyes;fluorodeoxyglucose;Free Radicals;Functional disorder;Generations;Genetic Transcription;Graft Rejection;Hemorrhage;Histologic;Histopathologic Grade;Homeostasis;Human;Hydrogen Peroxide;Image;image guided;imaging agent;imaging probe;Immunosuppression;improved;infection risk;Infiltration;Inflammation;Injections;Intervention;Lead;Left;Life;Lipids;Literature;Location;Longitudinal Studies;Lung;lung allograft;Lung Diseases;lung imaging;lung injury;Lung Transplantation;Macrophage Activation;male;Measures;Mediating;Membrane;Metabolism;Mitochondria;mitochondrial dysfunction;Modeling;Mole the mammal;Molecular;molecular imaging;Monitor;mouse model;Mus;muscle physiology;Names;nano;Non-Invasive Detection;Operative Surgical Procedures;Organ Transplantation;Outcome;Oxidation-Reduction;Oxidative Stress;oxidized lipid;Oxygen;pathogen;Pathogenesis;Pathology;patient stratification;Patients;Performance;PET/CT scan;Phase;Physiological;Pilot Projects;Play;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;preclinical development;Procedures;Production;Proteins;Psoriasis;Pulmonary Fibrosis;Pulmonary Inflammation;Pulmonology;Radiometry;radiotracer;Reactive Oxygen Species;Reference Standards;Regimen;Reporter;Reporting;Resources;response;Rest;Rheumatoid Arthritis;Risk;Risk Factors;Rodent;Role;Running;Safety;Saline;Signal Transduction;Skeletal Muscle;Solid;Specificity;Specimen;Structure of parenchyma of lung;Structure-Activity Relationship;Superoxides;Survival Rate;System;Tail;Techniques;Therapeutic;Tissues;tool;Toxicology;Tracer;Translations;transplant model;Transplantation;Treatment Efficacy;uptake;Validation;Veins

PROJECT_TITLE: PET Tracer for Imaging of Lung Inflammation

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: Aurora

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE Giardia lamblia is a global human parasite, and we need new therapeutic approaches that target the organism’s unique biological pathways. Here, we will explore our surprising discovery that 2A ‘self-cleaving’ peptides work very poorly in Giardia even though they function in all other eukaryotes tested. Our studies promise to reveal the mechanism of 2A function, fundamental aspects of Giardia biology, basic mechanisms of ribosome function, and to produce new tools to study Giardia.

PI_NAMEs: RISSLAND, OLIVIA SELFRIDGE (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Amino Acid Sequence;Anti-viral Agents;Biochemical;Biological;Biological Assay;Biological Models;Biological Process;Biology;Biomedical Research;Cells;Complex;Cryoelectron Microscopy;Development;Elements;Eukaryota;Event;Evolution;experimental study;Family Picornaviridae;Foot-and-Mouth Disease Virus;Foundations;Future;Generations;Genetic;Genome engineering;Giardia;Giardia lamblia;Giardiasis;Goals;Growth;Harvest;Human;human pathogen;Human poliovirus;interest;Intestinal Diseases;Knowledge;Life Cycle Stages;Mammals;Medicine;model organism;Modeling;Molecular;novel;novel therapeutic intervention;Open Reading Frames;Organism;Oryctolagus cuniculus;Parasites;Pathway interactions;Peptides;Peptidyltransferase;Persons;polypeptide;Positioning Attribute;protein aminoacid sequence;Recording of previous events;Reporter;Research;Research Personnel;Reticulocytes;Ribosomal Proteins;Ribosomes;RNA;Role;Saccharomyces cerevisiae;stem;Structural Models;Structure;System;Technology;Testing;Therapeutic;Time;tool;Translations;Variant;Viral;Virus Diseases;Work

PROJECT_TITLE: Self-cleaving peptides: Mechanisms and Use in Diverse Eukaryotic Species

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE PREMIER, the Precision Medicine in Rheumatology Center at UCSF will provide investigators with access to resources, expertise, training and pilot funding to capitalize on new technologies and opportunities in precision medicine. PREMIER will support innovative, collaborative studies to better define rheumatic disease subgroups that may have different etiologies, prognosis, or treatment responses. By providing Core resources in clinical research and informatics, state-of-the-art single cell molecular phenotyping and transcriptomics, and integrative bioinformatics analysis, PREMIER will advance studies of clinically phenotyped patient samples to improve diagnostic and treatment approaches to rheumatic disease.

PI_NAMEs: NAKAMURA, MARY C (contact)

PROGRAM_OFFICER_NAME: GARCIA-CAZARIN, MARY

PROJECT_TERMS: Acceleration;accurate diagnosis;Address;Area;autoimmune rheumatologic disease;Automobile Driving;Bioinformatics;Biology;California;Cells;Clinical;clinical care;Clinical Data;clinical heterogeneity;Clinical Informatics;clinical phenotype;Clinical Research;Clinical Treatment;cohort;Collaborations;Computational Biology;Consultations;Data;data dissemination;data modalities;data resource;data sharing;Databases;design;Development;Diagnosis;Diagnostic;Disease;disorder subtype;Educational workshop;Electronic Health Record;Ensure;Environment;Etiology;Evolution;Funding;Future;genomic data;Genomics;Goals;Grant;Heterogeneity;Immunology;Immunophenotyping;improved;Individual;Infrastructure;innovation;interdisciplinary approach;Interdisciplinary Study;interest;knowledge network;Leadership;member;Mentors;Methodology;Methods;Molecular;molecular phenotype;multiple omics;new technology;novel;novel therapeutics;Pathway interactions;Patients;Population;precision medicine;Prognosis;programs;Quality Control;Recording of previous events;Research;Research Design;Research Personnel;Research Project Grants;research study;Resources;Rheumatism;Rheumatology;Running;Sampling;San Francisco;Science;Selection for Treatments;Series;Services;single cell genomics;single cell sequencing;symposium;Talents;Technology;Training;transcriptomics;Translational Research;translational scientist;treatment response;Universities;Work

PROJECT_TITLE: RESOURCE-BASED CENTER FOR THE ADVANCEMENT OF PRECISION MEDICINE IN RHEUMATOLOGY


PROJECT_TERMS: autoimmune rheumatologic disease;Basic Science;biobank;Bioinformatics;Clinical;Clinical Informatics;Clinical Research;Clinical Sciences;cohort;Collaborations;Collection;Communication;Communities;Complex;Consultations;Data;Data Analyses;data streams;Databases;Development;Disease;Educational workshop;Ensure;experience;Fees and Charges;Fostering;Funding;Funding Opportunities;Genomics;Goals;Grant;Individual;Informatics;Infrastructure;innovation;interest;investigator training;Leadership;Link;Maintenance;meetings;member;Mentors;Needs Assessment;new technology;Newsletter;novel;Occupational activity of managing finances;operation;outreach;Patients;Phenotype;precision medicine;Preparation;programs;Progress Reports;Records;Reporting;Research;Research Design;Research Personnel;Resources;Rheumatism;Rheumatology;Sampling;Services;single cell genomics;targeted treatment;Technology;Training;United States National Institutes of Health;Universities;Utilization Review;videoconference;web site;Work

PROJECT_TITLE: Administrative Core


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Prevention;Primary Health Care;Social Determinants of Health;Telehealth

PHR: PROJECT NARRATIVE Most interventions to improve hypertension control focus on improving in-clinic care, but the full benefits of these interventions have not been realized by low-income patients (who may have transportation, cost, or time- related barriers to attending clinic visits) or in safety net systems (that may have limited fiscal or personnel resources to expand visit availability). This project aims to improve hypertension control in populations cared for in safety net systems by designing, piloting, and evaluating a home blood pressure monitoring program tailored to meet the needs of safety net patients and systems. Findings from this study will inform design and implementation of remote blood pressure monitoring programs for under-resourced settings and low-income populations with the overall aim of improving hypertension control and reducing disparities in preventable cardiovascular morbidity and mortality.

PI_NAMEs: KHOONG, ELAINE  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Address;Adopted;Adoption;Award;Behavior;Blood Pressure;Blood Pressure Monitors;California;Cardiovascular Diseases;cardiovascular disorder epidemiology;Cardiovascular system;career;Caring;Chronic Disease;Clinic;Clinic Visits;Clinical effectiveness;Clinical Pharmacists;Clinical Trials Design;Code;Complement;Consolidated Framework for Implementation Research;cost;Cost Analysis;cost comparison;cost effectiveness;Cost Effectiveness Analysis;Data;data integration;data resource;data tools;Decision Making;design;Development;digital;digital health;digital tool;disease disparity;Disease Management;Disparity;disparity reduction;effectiveness evaluation;effectiveness outcome;effectiveness/implementation trial;Electronic Health Record;Equity;Evaluation;evidence base;Evidence based practice;experience;Face;Focus Groups;Foundations;Frequencies;Funding;Future;Goals;Grant;handheld mobile device;Health;Health Care Sector;health disparity;Health Status;Health system;Healthcare;Home;Home Blood Pressure Monitoring;human centered design;Human Resources;Hybrids;Hypertension;hypertension control;implementation barriers;implementation evaluation;implementation intervention;implementation outcomes;implementation research;implementation science;implementation/effectiveness;improved;Individual;Informatics;Infrastructure;innovation;Insurance Coverage;Internist;Intervention;intervention cost;Interview;K-Series Research Career Programs;Lead;Leadership;literacy;literate;Literature;Low income;Low Income Population;Medicaid;member;Mentors;Methods;microcosting;Minority Groups;minority patient;Modeling;Morbidity - disease rate;mortality;Motivation;Nurses;Outcome;Ownership;participant enrollment;Patients;Persons;Pharmacists;Play;Population;Positioning Attribute;primary outcome;Process;professor;programs;prototype;Provider;Publishing;remote grading;remote monitoring;Research;Research Activity;Research Design;Research Personnel;Resource-limited setting;Resources;Role;safety net;San Francisco;Scientist;Site;skills;Surveys;System;system-level barriers;systems research;Team Nursing;Techniques;telehealth;Testing;theories;Time;tool;Training;Training Activity;Transportation;treatment as usual;Uninsured;Universities;usability;user-friendly;Visit;Work

PROJECT_TITLE: Designing a Remote Monitoring Intervention for Value & Equity in Hypertension (DRIVE-HTN)

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Networking and Information Technology R&D (NITRD);Precision Medicine

PI_NAMEs: YAZDANY, JINOOS  (contact)

PROJECT_TERMS: Abnormal coordination;Acceleration;Address;Basic Science;Bioinformatics;Biometry;Clinical;Clinical Data;Clinical Informatics;clinical phenotype;Clinical Research;Cohort Studies;Collaborations;Collection;Communities;Competence;Computer software;Consultations;Data;Data Analyses;Data Collection;data library;Data Linkages;data management;data resource;Databases;design;Development;Diagnosis;digital;Disease;disease phenotype;Education;Educational workshop;electronic health data;Electronic Health Record;Ensure;Epidemiologist;Epidemiology;Ethics Consultation;experience;Faculty;Funding;Genomics;Goals;Grant;Health;human subject;Human Subject Research;Individual;Informatics;informatics infrastructure;informatics tool;Infrastructure;innovation;Institution;interest;International;Knowledge acquisition;Learning Module;Link;member;Methods;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Natural History;novel;operation;Outcome Measure;Pathogenesis;patient oriented;Patient Recruitments;Patients;Phenotype;precision medicine;Productivity;programs;Reproducibility;Research;Research Design;Research Ethics;Research Infrastructure;Research Personnel;Research Project Grants;research study;Research Support;Resource Informatics;Resources;Rheumatism;Rheumatology;Risk Factors;Science;Scientist;Services;Spondylarthritis;Systemic Lupus Erythematosus;Technology;Testing;tool;Training;Translational Research;Vasculitis;Work

PROJECT_TITLE: Clinical Data and Informatics Core


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative Genetic variants located within non-coding sections of the genome have been extensively associated with changes in phenotypic variation, including human disease and complex traits such as height and weight. The aim of this project is to determine the relationship between genetic variants in non-coding regions of the genome and phenotypic changes at the molecular, cellular, and organismal scales. Successfully completing the proposed objectives will establish the molecular mechanisms linking genetic and phenotypic variation and provide a framework for unraveling the molecular determinants of human disease.

PI_NAMEs: MARAND, ALEXANDRE  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Affect;Alleles;Atlases;Award;Binding Sites;Biological Assay;Candidate Disease Gene;career;career development;causal variant;Cell Line;Cell Nucleus;cell type;Cells;Cellular Morphology;Chromatin;Chromatin Structure;Communication;Complex;Computer Analysis;Computer Models;cost;Coupled;Data;design;Development;Disease;DNA;DNA sequencing;Etiology;experimental study;Faculty;falls;Foundations;Future;Gene Order;Genes;Genetic;genetic approach;genetic information;Genetic Models;Genetic Polymorphism;Genetic Transcription;genetic variant;Genetic Variation;Genome;genome resource;genome wide association study;genome-wide;Genomic approach;Genomics;Genotype;Geography;Goals;Grant;Height;human disease;Human Genome;human model;Image;Individual;innovation;Institution;Investigation;Link;Linkage Disequilibrium;Machine Learning;Maize;Maps;Mediator;Mentors;Mentorship;Microscopy;Mission;model organism;Modeling;Molecular;mouse genome;mouse model;Outcome;Pattern;Phase;Phenotype;Plants;Population Sizes;Positioning Attribute;Postdoctoral Fellow;Primates;Proliferating;Quantitative Trait Loci;Regulatory Element;Research;Resolution;Resources;Role;single cell ATAC-seq;single nucleus RNA-sequencing;spatiotemporal;Specificity;stem;success;Techniques;Testing;Tissues;Training;Training Activity;trait;transcription factor;transcriptome;transcriptomics;Transgenic Organisms;United States National Institutes of Health;Untranslated RNA;Variant;Weight;Whole Organism;Work;Writing;Zea mays

PROJECT_TITLE: Exploration of cis-regulatory diversity underlying phenotypic innovation


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Mental Health;Neurosciences;Pediatric;Social Determinants of Health;Violence Research;Youth Violence

ORG_DEPT: PSYCHIATRY

PI_NAMEs: PERINO, MICHAEL T (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;Adverse event;Aggressive behavior;Amygdaloid structure;anti social;Anxiety;Attention;Award;Behavior;Behavioral;behavioral phenotyping;biobehavior;Biological Assay;Brain;bullying;callous unemotional trait;career;Childhood;community partners;cost;critical period;Data;demographics;design;Development;Dorsal;Empathy;Ensure;Functional disorder;Functional Magnetic Resonance Imaging;Future;Goals;Grant;Health;improved;Impulsivity;innovation;insight;Intercept;Intervention;life span;Link;Literature;maltreatment;Measures;Mental Depression;Mentorship;Mission;Modeling;Motivation;National Institute of Child Health and Human Development;neural;neurodevelopment;neuroimaging;Outcome;Parents;Participant;Pathway interactions;peer;perpetrators;Personality;Phase;Phenotype;polyvictimization;preference;Prefrontal Cortex;Process;psychologic;psychopathic personality;Psychopathology;Puberty;putamen;Questionnaires;recruit;Reporting;Research;Resistance;Resources;response;reward processing;Rewards;Risk Factors;Role;Sampling;Schools;Services;social;Social outcome;Social status;Socioeconomic Status;Specificity;statistics;Students;suicidal;Testing;Training;trait;Variant;Ventral Striatum;Violence;willingness;Work;Youth;youth violence

PROJECT_TITLE: Reward motivations associated with bullying trajectories


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Biotechnology;Genetics;Human Genome;Precision Medicine

PI_NAMEs: YE, CHUN JIMMIE (contact)

PROJECT_TERMS: Address;ATAC-seq;Autoimmune Diseases;autoimmune rheumatologic disease;Bioinformatics;Biological Assay;Biological Specimen Banks;Biology;career;Cell Physiology;Cell surface;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Censuses;Circulation;Clinical;Clinical Data;Clinical Informatics;clinical phenotype;Collaborations;Collection;Complex;Consultations;cost;Data;Data Analyses;data integrity;Data Management Resources;Data Set;data sharing;data streams;Development;direct application;Disease;disorder subtype;Dissection;electronic data;empowerment;Ensure;epigenome;Experimental Designs;experimental study;Generations;Genetic;Genetic Transcription;Genetic Variation;genome resource;Genomic approach;genomic data;genomic profiling;Genomics;Goals;high dimensionality;Human;Immune;immune function;Immunophenotyping;improved;Individual;Informatics;Infrastructure;innovation;Investigation;Investments;Leadership;Methodology;Methods;Molecular;Monitor;multimodality;novel;Pathogenesis;Pathway interactions;Patients;precision medicine;Preparation;Process;programs;Proteome;Proteomics;Quality Control;Reproducibility;Research;Research Design;Research Personnel;Resolution;Resources;Rheumatism;Rheumatology;RNA;Sampling;Secure;Service delivery model;Services;single cell genomics;single cell sequencing;single-cell RNA sequencing;skills;Spatial Distribution;Specimen;Standardization;Surface;Symptoms;System;Systemic Lupus Erythematosus;Technical Degree;Technology;Tissues;tool;transcriptome sequencing;transcriptomic profiling;transcriptomics;translational scientist;treatment response;Work;XCL1 gene

PROJECT_TITLE: Genomic Technology Core


ADMINISTERING_IC: AG

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

PHR: PROJECT NARRATIVE This long-standing training program produces innovative, ethical, and productive researchers cross-trained in social science and demography who will seek to incorporate interdisciplinary and translational components into their research. They develop specialized expertise in areas vital to public health, including the biosocial determinants of racial, ethnic, gender and socioeconomic differences in healthy aging. The ability of trainees to use the methods and theories of demography alongside outstanding disciplinary training produces scholars who generate and disseminate knowledge relevant to health and wellbeing from positions in government, academia, and research and policy organizations.

PI_NAMEs: BURGARD, SARAH A. (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Aging;Demography;Economics;Training

PROJECT_TITLE: Training in the Demography and Economics of Aging


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Substance Misuse

ORG_CITY: STANFORD

ORG_DEPT: BIOPHYSICS

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Opioids act as agonists of opioid receptors and are amongst the most effective analgesics, but they come with serious side effects and a high potential for abuse. To date, we know little about the molecular mechanisms mediating the beneficial and adverse actions of opioids. Our proposed studies combine proteomics and functional genomics to discover regulators of mu-opioid receptor activation, which may identify new therapeutic targets for pain and addiction.

PI_NAMEs: HUTTENHAIN, RUTH  (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: abuse liability;Accidents;addiction;Address;Adverse effects;Agonist;Analgesics;antagonist;beta-arrestin;Biochemical;Biological Assay;Biology;Cell Line;Cell membrane;Cell model;Cells;Cessation of life;Chemicals;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR interference;CRISPR screen;Cyclic AMP;Data;data integration;design;Down-Regulation;Endosomes;Epidemic;experimental study;functional genomics;gene discovery;Gene Expression Regulation;Genes;Genetic Screening;Genetic Transcription;Genomics;Goals;Golgi Apparatus;GTP-Binding Proteins;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;insight;knock-down;Knock-out;Knowledge;Label;Ligand Binding;Ligands;Location;MAPK Signaling Pathway Pathway;Maps;Mass Spectrum Analysis;Mediating;Membrane;Modality;Molecular;mu opioid receptors;Neurons;new therapeutic target;novel;novel therapeutic intervention;Opiate Addiction;Opioid;opioid abuse;Opioid agonist;opioid epidemic;Opioid Receptor;opioid use;Overdose;Pain;Pathway interactions;Peptides;Pharmaceutical Preparations;Phenotype;phosphoproteomics;Phosphorylation;presynaptic;protein function;Proteins;Proteome;Proteomics;receptor;Receptor Activation;receptor internalization;Receptor Signaling;Recycling;Reporter;response;Role;side effect;Signal Pathway;Signal Transduction;spatiotemporal;synaptic inhibition;Synaptic Vesicles;Testing;trafficking;Transducers;Validation;Ventilatory Depression;Work

PROJECT_TITLE: Spatiotemporal signaling and trafficking of the mu-opioid receptor


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention

PI_NAMEs: SIROTA, MARINA  (contact)

PROJECT_TERMS: Basic Science;Bioinformatics;cell type;Cells;Clinical;Clinical Data;Clinical Informatics;clinical phenotype;Clinical Research;Collaborations;community center;Complex;Computational Biology;Computer Analysis;Computer software;computerized tools;Consultations;Cytometry;Data;Data Analyses;data dissemination;data integration;data library;data management;data modalities;Data Science;Data Set;data sharing;Data Storage and Retrieval;Database and Analysis Portal;Development;Disease;disorder prevention;Doctor of Philosophy;Early Diagnosis;Early treatment;Education;Electronic Health Record;empowerment;Environmental Exposure;experience;feature extraction;Genetic;Genomics;Goals;Image;Immune;Immune system;Immunology;individual variation;Informatics;Infrastructure;innovation;Interest Group;Life Style;Measurement;Measures;Medical History;Molecular;Molecular Profiling;multimodality;novel;outreach;Pharmacogenomics;Pharmacologic Substance;precision medicine;Process;programs;Research;Research Design;Research Personnel;research study;Resolution;Resources;Retrieval;Rheumatism;Rheumatology;Science;Secure;Services;single cell genomics;single cell sequencing;System;Techniques;Technology;Time;tool;transcriptomics;Translational Research;translational study;Visualization;web platform;Work

PROJECT_TITLE: Integrative Bioinformatics Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Machine Learning and Artificial Intelligence

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative Identification of senescent cells in tissues is particularly challenging as it requires detection of sets of markers that can be cell type specific. Our goal is to develop single cell multi-omic imaging technology to measure proteins, RNA and the DNA’s 3-dimensional conformation in senescent cells and in their microenvironment, in a diverse set of tissues. This new technology will allow us to better understand the heterogeneity of the senescent phenotype in tissues, and to study how senescent cells affect the status of neighboring cells.

PI_NAMEs: MA, JIAN ;NERETTI, NICOLA  (contact);WANG, SIYUAN

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: 3-Dimensional;Adipose tissue;Affect;Age;age-related disease;Biological;Brain;Cell Aging;Cell Culture Techniques;Cell Cycle;Cell Nucleus;cell type;Cells;Chemotherapy and/or radiation;Chronic;Collaborations;Communities;Complex;computer framework;Data;Degenerative polyarthritis;Detection;Diabetes Mellitus;Disease;Dissociation;DNA;DNA Damage;epigenomics;Feasibility Studies;Fibrosis;Generations;Genes;Genetic Transcription;Genome;Genomics;Goals;Heart Diseases;Heterogeneity;high dimensionality;Homeostasis;Human;human tissue;Imaging technology;Immune system;Immunologic Surveillance;improved;Individual;Inflammation;Intervention;Intrinsic factor;Laboratories;Link;Liver;Machine Learning;machine learning method;Malignant Neoplasms;Maps;Measures;Methodology;Methods;Microscopy;Modeling;Molecular;Molecular Conformation;multidisciplinary;Multiomic Data;multiple omics;Mus;Nerve Degeneration;new technology;novel;Nuclear;Outcome;Phase;Phenotype;Physiology;Positioning Attribute;Production;programs;Proteins;Proteomics;Relapse;Resolution;response;RNA;Role;Sampling;scale up;senescence;senescence associated secretory phenotype;senescent cell;senolytics;senomorphic;Sensitivity and Specificity;Series;single cell sequencing;Technology;Tissue Banks;tissue mapping;Tissues;tool;Transcript;transcriptome;transcriptomics;Tumor Promotion;Tumor Suppression;ultra high resolution;United States National Institutes of Health;Work;wound healing

PROJECT_TITLE: Spatial omics technologies to map the senescent cell microenvironment


NIH_SPENDING_CATS: Aging;Bioengineering;Digestive Diseases;Genetics;Human Genome;Liver Disease

ORG_DEPT: PHYSIOLOGY

PHR: PROJECT NARRATIVE We recently developed Seq-Scope, a spatial transcriptomics solution which can provide unprecedented resolution and outstanding data output. In the enclosed proposal, we propose to adapt Seq-Scope for detection and characterization of senescent cells from normal human tissue.

PI_NAMEs: LEE, JUN HEE  (contact)

PROJECT_TERMS: age related changes;Aging;Architecture;Area;Atlases;Bar Codes;Cell Aging;Cell Nucleus;Cell Separation;cell type;Cells;Colon;Complement;Cytoplasm;Data;Detection;Dissociation;droplet sequencing;Eye;Fibrosis;Freezing;Genes;Genome;Genomics;Hepatic;Hepatocyte;Heterogeneity;Histologic;histological slides;Human;human tissue;improved;In Situ Hybridization;in situ sequencing;Inferior;Inflammation;Libraries;Lipids;Literature;Liver;Liver diseases;liver injury;Location;Methodology;Methods;Microscope;Microscopic;Mitochondria;Molecular Target;Monitor;Mus;Names;Oligonucleotide Microarrays;Optics;Output;Performance;Phase;Population;Printing;Procedures;Process;protein biomarkers;Proteins;Research Personnel;Resolution;Resources;response;RNA;RNA Sequences;Sampling;senescence;senescent cell;single-cell RNA sequencing;Slide;Solid;Surface;System;Techniques;Technology;technology development;Time;tissue mapping;Tissues;Transcript;transcriptome;transcriptomics;Visualization;Vulnerable Populations;Work

PROJECT_TITLE: Seq-Scope: Microscopic Examination of Spatial Single Cell Transcriptome in Cell and Tissue Senescence


ORG_DEPT: BIOLOGY

PHR: PROJECT NARRATIVE This project aims to understand the mechanism of the eukaryotic chaperonin TRiC/CCT, a ring- shaped hetero-oligomeric complex that folds many essential cellular proteins in an ATP- dependent manner. Recent observations have highlighted the links between TRiC and several pathological states incuding cancer, viral infection and neurodegeneration. Thus our project deciphering the mechanism of this chaperonin in cellular folding will help develop therapies to ameliorate these human diseases.

PI_NAMEs: FRYDMAN, JUDITH  (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Actins;Address;Allosteric Regulation;Apical;ATP Hydrolysis;ATP phosphohydrolase;Binding;Binding Sites;Biochemical;Biological Assay;Biophysics;Cells;chaperonin;Code;cofactor;Complex;Consensus;crosslink;Cryoelectron Microscopy;Data;Encapsulated;Eukaryotic Cell;experimental study;Fluorescence;Fluorescence Spectroscopy;Funding;Genetic;Goals;Heterogeneity;Homo;Human;human disease;Hydrolysis;Individual;insight;Link;Malignant Neoplasms;Mediating;member;Modeling;Molecular;Molecular Chaperones;Molecular Conformation;Mutagenesis;mutant;Mutation;Nerve Degeneration;Nucleotides;Pathologic;Pathway interactions;Peptide Library;Peptide Phage Display Library;Play;polypeptide;programs;Property;protein complex;protein folding;Proteins;Recombinants;response;Role;Shapes;Substrate Domain;Substrate Interaction;Surface Plasmon Resonance;System;Testing;therapy development;Time;tool;Variant;Virus Diseases;Work;Yeasts

PROJECT_TITLE: Mechanism of the Eukaryotic Chaperonin TRiC/CCT

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


NIH_SPENDING_CATS: Hematology;Infectious Diseases;Microbiome;Nutrition;Rare Diseases;Sickle Cell Disease

ORG_CITY: NEW YORK

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative: Patients suffering from sickle cell disease (SCD) present with repetitive, intermittent and painful blood vessel blockage and can succumb to premature death caused by accumulating damage to all major organs. Our preliminary data suggest that gut bacteria mediate the development of chronic organ damage in SCD. The proposed studies will advance our understanding of SCD pathophysiology and may lead to the development of new cost-effective, microbiome-based therapies for SCD patients so that they can live longer and more fulfilling lives.

PI_NAMEs: LI, HUIHUI  (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Address;Affect;Africa South of the Sahara;American;Antibiotics;Antibodies;Area;Autoimmune;Bacteria;Bacterial Toxins;Bacterial Translocation;Belief;beta Globin;biological adaptation to stress;Blood Vessels;Bypass;career development;Cause of Death;Cell Adhesion;Cell membrane;Cells;Cessation of life;Chronic;Circulation;Complex;cost;cost effective;Data;Deposition;Development;Development Plans;Diet;dietary control;Dietary Iron;dietary restriction;Disease Progression;Distant;Enterococcus gallinarum;Erythrocytes;Exhibits;Functional disorder;Genes;germ free condition;Germ-Free;Goals;gut bacteria;gut microbiome;gut microbiota;Hematological Disease;Hemolysis;Hospitalization;IL17 gene;Immune system;Immunologic Stimulation;Impairment;improved;Individual;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;Inherited;insight;Intestinal permeability;Intestines;Iron;iron metabolism;Iron Overload;Leaky Gut;Liver;liver function;liver injury;Mediating;Microbe;microbial;microbial composition;microbiome;microbiome composition;microbiome therapeutics;microbiota;mouse model;Mucous body substance;murine colitis;Mus;Mutation;novel;Organ;organ growth;Oxidative Stress;Pain;pathogen;pathogenic bacteria;Pathogenicity;Patients;Permeability;Portal vein structure;premature;prevent;Probiotics;recruit;Renal function;Reporting;Research;Resources;Ribosomal DNA;Role;Sickle Cell;Sickle Cell Anemia;Signal Transduction;Specificity;stool sample;Stress;Testing;Therapeutic;Tight Junctions;Training;Travel;treatment group;United States;Up-Regulation;Vaccines;Work

PROJECT_TITLE: The microbiome determines organ damage development in sickle cell disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK(M1)-1-D]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cocaine;Microbiome;Neurosciences;Nutrition;Physical Injury - Accidents and Adverse Effects;Prevention;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: MONTGOMERY

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: ALABAMA STATE UNIVERSITY

ORG_STATE: AL

PHR: PROJECT NARRATIVE In this proposal, we will test the impact of cocaine use on the microbiota of selected tissues associated with the gut-brain axis. Knowing that imbalances in microbial composition or activity arising from chronic cocaine use influences health and is implicated in various diseases (e.g., leaky gut and mood disorders), our studies will be executed in tissues extracted from African-American overdose cases from three Southern regions of the United States. Since the gut microbiome plays major roles in maintaining human health, our studies will contribute fundamental knowledge to enhancing the well-being of individuals with cocaine abuse disorders.

PI_NAMEs: JAVAN, GULNAZ  (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Actinobacteria class;addiction;Addictive Behavior;Adrenal Glands;Adverse effects;Affect;African;African American;African American population;Age;Alabama;American;Analysis of Variance;Autopsy;Bacteria;Bacteroidetes;Basal Ganglia;Bioinformatics;Biological Markers;Blood - brain barrier anatomy;Body mass index;Brain;Cadaver;career;Caring;Cells;Cerebrum;Cessation of life;Characteristics;Chloroform;Chronic;Cocaine;Cocaine Abuse;Cocaine Dependence;cocaine overdose;cocaine use;Colon;Communication;cost;Data;Death Rate;Determination of Death;Development;Disease;Disparity;Distal;Double-Blind Method;Drug Addiction;drug of abuse;Educational workshop;emotional behavior;Endocrine system;Ensure;Evaluation;experience;Farm;Fentanyl;Firmicutes;Florida;Future;Goals;Grant;gut dysbiosis;gut microbes;gut microbiome;gut microbiota;gut-brain axis;Health;Homeostasis;Human;human tissue;Hypothalamic structure;ileum;Illicit Drugs;Individual;innovation;insight;Intoxication;Investigation;Knowledge;knowledgebase;Leaky Gut;Link;Location;mathematical model;Mediating;Medical;metabolomics;Metagenomics;Microbe;microbial;microbial composition;microbial signature;microbiome;microbiota;microbiota-gut-brain axis;microorganism;Mood Disorders;novel;novel diagnostics;Organ;Overdose;Pathogenesis;Personal Satisfaction;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phenols;Pilot Projects;Pituitary Gland;Play;Polymerase Chain Reaction;Population;Predisposition;prevent;Process;Productivity;Proliferating;Proteobacteria;Race;receptor binding;Reproducibility;Research Personnel;Risk;Risk Factors;Role;Sampling;Science;sex;Single-Blind Study;Site;Specimen;Sterility;Substance Use Disorder;Systems Analysis;Tennessee;Testing;Texas;therapeutic target;Tissue Extracts;Tissues;Transverse colon;undergraduate student;United States;Universities;virtual;Work

PROJECT_TITLE: Investigating microbiota of the gut-brain axis and the impact of cocaine


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Biomedical Imaging

ORG_CITY: CLEVELAND

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Relevance to Public Health. Biomedical imaging enables early disease detection, assessment of therapy, and minimally invasive treatment of disease. Especially with the advent of cellular and molecular imaging and machine/deep learning, biomedical imaging research requires persons with strong interdisciplinary training.

PI_NAMEs: WILSON, DAVID LYNN (contact);YU, XIN

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: biomedical imaging;Training Programs

PROJECT_TITLE: Interdisciplinary Biomedical Imaging Training Program


ORG_DEPT: PEDIATRICS

PHR: Overall Narrative Molecular blueprints would dramatically enhance our ability to design effective approaches to intervene and prevent kidney dysfunction in children. The objective of the Washington University Kidney Single Cell Atlas Project (pKidCAP) is to create a highly unique and innovative Pediatric Center of Excellence that delivers novel concepts, knowledge and resources by providing spatially resolved single cell molecular maps of pediatric reference and diseased kidneys at several time points across the pediatric lifespan. The pKidCAP investigators will apply paired snRNAseq, snATACseq technologies for decoding gene regulation and expression from the same cell and use spatial transcriptomics to resolve the cellular diversity with morphology using healthy and disease samples from pediatric kidneys procured from the Biomedical core and in mouse model of glomerular disease.

PI_NAMEs: HALABI, CARMEN M.;JAIN, SANJAY  (contact)

PROGRAM_OFFICER_NAME: GIPSON, DEBBIE SUE

PROJECT_TERMS: Acceleration;Acute Renal Failure with Renal Papillary Necrosis;Adult;Age;age related;Aging;analytical tool;Atlases;Biological;Biopsy;Body System;Cell Differentiation process;Cell Line;Cell Nucleus;cell type;Cells;Child;Childhood;Chromatin;Chronic Kidney Failure;cohort;Communities;Complement;congenital anomaly;Data;data mining;Data Set;design;design verification;Development;disability;Discipline;Disease;disease model;Drug toxicity;Early Diagnosis;Education;Educational Activities;Educational workshop;effective intervention;empowerment;Engineering;Environment;Environmental Exposure;fetal;Focal and Segmental Glomerulosclerosis;Future;Future Generations;Gene Expression;Gene Expression Regulation;gene function;Genes;Genetic;genetic variant;Genomics;Goals;Human;Hyperoxia;Hypertension;Image;Impairment;induced pluripotent stem cell;Infection;Injury;innovation;Instruction;Intensive Care;interest;Ischemia;Kidney;Kidney Calculi;kidney cell;Kidney Diseases;kidney dysfunction;Kidney Failure;Knowledge;Length of Stay;life span;Machine Learning;Maps;Measurement;Methods;Mind;Molecular;Morphology;mortality;mouse model;multimodal data;multimodality;multiple omics;Mus;Neonatal;nephrogenesis;Nephrology;nephrotoxicity;novel;Organoids;Pathologic;Patients;Pharmaceutical Preparations;Physiological;postnatal;postnatal development;postnatal human;prevent;Printing;programs;Proteinuria;Protocols documentation;Renal glomerular disease;Reporter;Research;Research Personnel;Research Project Grants;Resources;Role;Sampling;Scholars Program;screening;Severities;single nucleus RNA-sequencing;Source;Specimen;Students;symposium;synergism;Technology;Therapeutic;Time;Tissue Engineering;Tissue Sample;Tissues;tool;transcriptomics;Universities;Urinary tract;validation studies;Washington

PROJECT_TITLE: Pediatric Kidney Single Cell Atlas Project


NIH_SPENDING_CATS: Kidney Disease;Pediatric

PI_NAMEs: JAIN, SANJAY  (contact)

PROJECT_TERMS: Advisory Committees;Area;Atlases;Award;Awareness;career;Cells;Childhood;Clinical;Collaborations;collaborative approach;Communities;Data;Data Analytics;data sharing;design;Education;Educational Activities;Eligibility Determination;Ensure;experience;Feasibility Studies;Fostering;Funding;Funding Mechanisms;Goals;Individual;Infrastructure;innovation;Institution;instrument;Intellectual Property;interest;International;investigator training;Joints;Journals;Kidney;Kidney Diseases;Knowledge;lectures;meetings;member;Mentors;Minority-Serving Institution;Mission;Nephrology;outreach;Participant;Periodicals;Pilot Projects;Play;Productivity;Program Reviews;programs;Progress Reports;public repository;Research;Research Activity;Research Personnel;Research Project Grants;Research Support;Resource Allocation;Resources;Role;Running;Scholars Program;Series;Services;Site;Student recruitment;Students;summer research;Techniques;Technology;Testing;Time;Travel;United States National Institutes of Health;Universities;Visit;visiting scholar;Washington;web site;Work


ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: NARRATIVE A multifaceted research approach is required to eliminate the human immunodeficiency virus type one (HIV-1) from its myeloid reservoirs that include the central nervous system. To this end, biological, biochemical, molecular, theranostic and immunological approaches are outlined to detect, target then eliminate HIV-1 infectious myeloid reservoirs. The proposed works include novel antiretroviral and gene therapeutic strategies.

PI_NAMEs: GENDELMAN, HOWARD E;GORANTLA, SANTHI  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Affect;animal imaging;Animal Model;Anti-Retroviral Agents;antiretroviral therapy;Astrocytes;Biochemical;Biodistribution;bioimaging;Biological;Biology;Birth;Blood Vessels;blood-brain barrier function;Brain;brain tissue;CD34 gene;Cells;Central Nervous System;chronic infection;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Dendritic Cells;design;Disease;DNA;Evaluation;Evolution;Excision;experimental study;extend lifespan;fluorophore;Formulation;Foundations;gene therapy;Genes;Giant Cells;Goals;Growth;Guide RNA;Hematopoietic Stem Cell Transplantation;HIV;Homeostasis;Human;human disease;human model;humanized mouse;Hydrophobicity;immunoaffinity chromatography;Immunologics;improved;Infection;innovation;Interruption;Invaded;Knowledge;Laboratories;late endosome;Link;lipid nanoparticle;lipophilicity;Lymphoid;Lymphoid Tissue;Macrophage;Mass Spectrum Analysis;memory CD4 T lymphocyte;Methods;Microglia;Mind;Molecular;Molecular and Cellular Biology;monocyte;Mononuclear;mouse model;Mus;Myelogenous;nano;nanocrystal;nanoformulation;nanoparticle;Nebraska;neuroAIDS;neurocognitive disorder;novel;novel therapeutics;Nuclear;Organ;particle;Pathway interactions;Penetration;Pericytes;Peripheral;Persons;Phagocytes;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacology;Polymer Chemistry;Predisposition;Proteins;Radiolabeled;Recycling;Reporter;Research;Research Activity;response;Rest;RNA;self-renewal;single-molecule FRET;Site;Speed;Spinal Cord;Sterilization;Subcellular Fractions;System;targeted delivery;Techniques;Testing;theranostics;Therapeutic;therapeutic evaluation;therapeutic gene;Therapeutic Intervention;therapeutic nanoparticles;therapeutically effective;Tissues;trafficking;transmission process;treatment response;Tropism;Variant;Viral;viral rebound;Viral reservoir;virology;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: HIV-1DetectionandEliminationFrom CNS Mononuclear Phagocytes


PI_NAMEs: PRYHUBER, GLORIA S (contact)

PROJECT_TERMS: Acceleration;Adolescent;Adopted;Adult;age related;Aging;Atlases;Authorization documentation;Biological Assay;biological research;Biology;Biomedical Research;Biopsy;Cell Line;cell type;Cells;Child;Childhood;Clinical;Collaborations;Communities;Consent;Data;delivery complications;design;design verification;Development;Distal;Drug toxicity;Early Diagnosis;effective intervention;End stage renal failure;Engineering;Ensure;epigenome;FAIR principles;fetal;gene function;Generations;Gifts;Goals;Human;Hypertension;Image;Incidence;induced pluripotent stem cell;Infant Mortality;Infrastructure;innovation;Instruction;interest;interoperability;Kidney;kidney cell;Kidney Diseases;kidney dysfunction;Kidney Failure;Knowledge;Life;life span;Measurement;Methods;Molecular;molecular imaging;Morphology;multimodality;multiple omics;Nature;Neonatal;Nephrology;Nephrons;operation;Organ;Organ Transplantation;Organoids;Parents;Pathologic;Pathology;Patients;Pediatric Research;Physiological;Policies;Positioning Attribute;postnatal;premature;preservation;prevent;Procedures;Protocols documentation;Provider;Publishing;quality assurance;Quality Control;Reporter;repository;Research;Research Personnel;Resources;Sampling;screening;Severities;single cell technology;Source;Specimen;Technology;Time;Tissue Banks;Tissue Engineering;tissue processing;Tissue Sample;Tissues;transcriptome;Translational Research;Trauma;United States;Universities;validation studies;Washington

PROJECT_TITLE: Biomedical Research Core


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Kidney Disease;Pediatric;Urologic Diseases

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Adult;Affect;Age;age group;Aging;analytical tool;Anatomy;Animal Model;Architecture;ATAC-seq;Atlases;Benchmarking;Biopsy;Birth;Bladder;Body System;Cardiovascular Diseases;Cause of Death;Cell Differentiation process;Cell Nucleus;cell type;Cells;Cessation of life;Child;Childhood;Childhood Injury;Chromatin;Chronic Kidney Failure;Clinical;clinical phenotype;cohort;Communities;congenital anomalies of the kidney;congenital anomaly;coping;Coupled;Data;data mining;Data Set;design;Dimensions;disability;Disease;disease model;DNA;Drug Design;Early Diagnosis;Embryo;End stage renal failure;Environment;Environmental Exposure;Epigenetic Process;Etiology;extracellular;fetal;Focal and Segmental Glomerulosclerosis;Functional disorder;Future;Gene Expression;gene regulatory network;Generations;Genes;genome sequencing;genome wide association study;Genomics;Growth;Histologic;Homeostasis;Human;human disease;Hyperoxia;Hypertension;Impairment;induced pluripotent stem cell;Infection;innovation;insight;Intensive Care;interest;Investigation;Ischemia;Kidney;kidney biopsy;Kidney Calculi;Kidney Diseases;kidney dysfunction;Kidney Failure;Knowledge;Length of Stay;Life Cycle Stages;life span;Link;Lower urinary tract;Machine Learning;Maps;Methods;Molecular;Molecular Profiling;mortality;multidimensional data;multimodal data;multimodality;multiple omics;Neonatal;nephrogenesis;nephrotoxicity;Organ;Organoids;outcome prediction;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;Physiological;Population;postnatal;postnatal period;preservation;Procedures;Process;Proteinuria;Protocols documentation;Puberty;quality assurance;Quality Control;Quality of life;Race;recurrent infection;Regulatory Element;Renal function;Renal glomerular disease;repaired;Research;Research Personnel;Research Priority;Research Project Grants;Resources;RNA;Sampling;Second Pregnancy Trimester;sex;Sex Differences;single nucleus RNA-sequencing;Site;Source;Specimen;Standardization;Structure;Students;Study models;System;Technology;Therapeutic;Time;Tissue Engineering;Tissues;trait;transcriptomics;Tubular formation;Urinary tract;Uterus;Variant;whole genome

PROJECT_TITLE: Research Project 1: A Multidimensional Molecular Atlas of Healthy and Diseased Human Pediatric Kidney


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Prevention;Sleep Research;Substance Misuse

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Insomnia is prevalent among adults who engage in heavy drinking, but it is rarely targeted in alcohol prevention or treatment. The proposed study will test the efficacy of an evidence-based insomnia treatment in reducing heavy alcohol use and related problems among adult men and women in the United States. Findings will directly inform clinical practice by documenting the impact and potential mechanisms of insomnia treatment on alcohol-related outcomes.

PI_NAMEs: MILLER, MARY ELIZABETH (contact)

PROGRAM_OFFICER_NAME: KUMAR, SHAILESH

PROJECT_TERMS: actigraphy;Adult;Aftercare;Alcohol abuse;alcohol abuse therapy;alcohol behavior;alcohol consequences;Alcohol consumption;alcohol craving;alcohol prevention;alcohol related consequences;alcohol risk;alcohol use disorder;Alcohols;Behavior;behavior change;binge drinking;Blood;Blood Pressure;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;Chronology;clinical practice;clinically significant;Cognitive Therapy;comorbidity;craving;Data;density;design;Development;Diagnostic;discounting;drinking;Dyslipidemias;Economic Burden;effectiveness evaluation;Effectiveness of Interventions;efficacious treatment;efficacy evaluation;efficacy testing;Emotional;Evaluation;evidence base;Executive Dysfunction;executive function;Female;follow-up;Glucose;Goals;hazardous drinking;Health;Health Care Costs;Heavy Drinking;heavy drinking young adult;High Density Lipoproteins;Hypertension;improved;Individual;innovation;Intervention;life span;Link;Measurement;Mediating;Mediation;Mediator;men;Mental disorders;Mental Health;Metabolic;Modeling;multilevel analysis;National Institute on Alcohol Abuse and Alcoholism;Outcome;Participant;Pathway interactions;Persons;Pharmacological Treatment;pilot trial;Population;Pre-Clinical Model;prevent;primary outcome;psychologic;Public Health;public health relevance;Randomized;Randomized, Controlled Trials;reduce symptoms;Relapse;Reporting;Research;Severities;sex;Sex Differences;Sleep;Sleep Disorders;sleep health;sleep onset;Sleeplessness;social;Stigmatization;Strategic Planning;Surveys;Symptoms;Triglycerides;United States;Waiting Lists;Woman;Work;young adult

PROJECT_TITLE: Sleep as a Mechanism of Change in Alcohol Use Outcomes among Heavy-Drinking Adults

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Genetics;Human Genome;Kidney Disease;Pediatric;Prevention;Rare Diseases

PHR: Project Narrative Currently, there are limited therapeutic options for treating pediatric kidney disorders because of a limited understanding of disease mechanisms. To advance the field, we will use state-of-the-art interrogation technologies to create a molecular atlas of the maturing post-natal kidney in healthy mice and in a model of human disease. The proposed research is relevant to public health and to the NIH’s mission because the information learned from these studies will provide novel insights that may lead to rational therapeutic targets for kidney diseases affecting infants, children and adolescents.

PI_NAMEs: RAUCHMAN, MICHAEL I (contact)

PROJECT_TERMS: Adolescence;Adolescent;Adult;Affect;Age;Age Months;Albuminuria;ATAC-seq;Atlases;Biological Assay;Biopsy;Birth;Cell Aging;Cell Differentiation process;cell type;Cells;Child;Childhood;ChIP-seq;Chromatin;Chromatin Remodeling Factor;Chromium;Clinical;congenital anomalies of the kidney;Coupled;critical developmental period;Data;data integration;Data Set;Deacetylase;Defect;derepression;Development;Diagnosis;Disease;Disease Progression;Early Diagnosis;Embryo;emerging adult;End stage renal failure;Endowment;Epigenetic Process;epigenome editing;Evolution;Failure;Fatty acid glycerol esters;fetal;Focal and Segmental Glomerulosclerosis;Frequencies;functional adaptation;Gene Activation;Gene Expression;Gene Expression Profile;gene regulatory network;Genes;genetic risk factor;Glean;glomerulosclerosis;Growth;Health;High Fat Diet;high risk;high salt diet;Human;human disease;human model;Hypertension;Hypoxia;Immune;improved;Infant;Inflammation;injured;Injury;Injury to Kidney;insight;Kidney;Kidney Diseases;Kidney Failure;Lead;Learning;Life;life span;lipid metabolism;Lipids;Localized Disease;loss of function;Metabolic;Metabolic stress;Metabolism;Metastasis-associated protein;Mission;Modeling;Molecular;Molecular Analysis;Morphology;mortality;mouse model;Multiomic Data;multiple omics;Mus;mutant;Mutant Strains Mice;Neighborhoods;nephrogenesis;nephron progenitor;Nephrons;Nephrotic Syndrome;novel;Nucleic Acid Regulatory Sequences;Nucleosomes;Obesity;Pathway interactions;peer;Phenotype;Physiological;Play;postnatal;postnatal period;potential biomarker;Predisposition;programs;progression risk;Public Health;Recurrence;Regulatory Element;Renal function;Renal glomerular disease;repaired;Research;Research Project Grants;Resistance;Risk Factors;Role;senescence;Signal Pathway;single nucleus RNA-sequencing;Small Nuclear RNA;stem cells;Stress;Technology;Testing;Therapeutic;therapeutic target;Time;Tissues;Transcription Factor AP-1;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Urinary tract

PROJECT_TITLE: Research Project 2: Molecular analysis of developing post-natal mouse kidney in health and FSGS


ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Prevention;Rehabilitation;Social Determinants of Health;Women's Health Research

ORG_CITY: BOSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: PROJECT NARRATIVE We aim to adapt and pilot a guided self-help stress management program from the World Health Organization and to incorporate peer cancer survivors in providing psychosocial support to breast cancer patients in Viet Nam. We seek to demonstrate the feasibility of the culturally and contextually adapted intervention in reducing the psychological distress associated with cancer diagnosis and treatment, to ultimately improve cancer patients’ health outcomes. Successful completion of the project begins to fill the gaps in the lack of culturally appropriate evidence-based mental health interventions for cancer patients in many low- and middle-income countries, and in many racial/ethnic groups in the U.S.

PI_NAMEs: LE, PHUONGTHAO DINH (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Academic Training;Address;Adherence;Affect;anti-cancer research;Area;Behavior Therapy;Behavioral Sciences;Breast;Breast Cancer Patient;Breast Cancer survivor;cancer care;Cancer Center;Cancer Control;cancer diagnosis;Cancer Hospital;Cancer Intervention;Cancer Patient;cancer prevention;Cancer Survivor;cancer therapy;cancer type;care systems;career;career development;Caregivers;Cessation of life;Cities;clinically significant;Cognitive Therapy;Communities;community based participatory approach;community based participatory research;Community Health;coping;Country;design;Development;Diagnosis;Dimensions;Disease;Distress;Doctor of Philosophy;Effectiveness;Elements;Emotional;Ethnic Population;evidence base;Evidence based intervention;experience;Fellowship;Female Breast Carcinoma;flexibility;Focus Groups;Funding;Future;Goals;Health;health management;Health Personnel;Health Policy;Health Sciences;Health Services Research;Hospitals;Hour;implementation science;implementation strategy;improved;Incidence;Individual;informant;International;Intervention;Interview;Knowledge;Language;low and middle-income countries;Malignant Breast Neoplasm;Malignant Neoplasms;Manuals;marginalized population;Mathematics;Medical;Mental disorders;Mental Health;Mental Health Services;Mentored Research Scientist Development Award;Mentors;Mentorship;Modeling;Modification;multidisciplinary;National Cancer Institute;New York;Newly Diagnosed;Oncology;Outcome;Participant;participant observation;peer;peer coaching;peer support;Persons;Pilot Projects;Population;Postdoctoral Fellow;Prevalence;Prevention Guidelines;process evaluation;programs;psychologic;psychological distress;psychosocial;Psychosocial Assessment and Care;psychosocial outcome;Public Health;Qualitative Research;Quality of life;racial population;Recommendation;Reporting;Research;Research Activity;Research Assistant;residence;Resource-limited setting;Schools;Scientist;self help;Site;skills;Social Sciences;Social support;Specific qualifier value;stress management;Structure;Supportive care;Testing;Training;Training Activity;treatment guidelines;Universities;uptake;Vietnam;Vietnamese;Woman;working group;World Health Organization

PROJECT_TITLE: Adaptation and Pilot of a Peer-Facilitated Self-Help Plus Stress Management Intervention for Breast Cancer Patients in Viet Nam

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-L(57)R]