NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Immunization;Immunotherapy;Neurodegenerative;Neurosciences;Prevention;Vaccine Related;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: IRVINE

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative  Recent results from human clinical trials utilizing administration of three different monoclonal antibodies targeting Aβ , aducanumab , and lecanemab, and donanemab have slowed mental decline by approximately 35 percent. Thus, there is increased interest in identifying the cellular and molecular mechanisms underlying the persistent adverse clinical brain blood vessel responses to passive anti-Ab immunotherapy. This R01 proposal will utilize a transgenic mouse model that deposits high levels of brain and vascular Aβ to investigate these immunotherapy-induced adverse events with a mouse monoclonal anti-Aβ antibody, where the human version, bapineuzumab, has previously been shown to have reduced Aβ plaque pathology in patients, as well as induced adverse clinical brain blood vessel responses.

PI_NAMEs: CRIBBS, DAVID HASTINGS (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: abeta deposition;Ablation;Active Immunization;Aducanumab;Adverse event;Age;Aging;Agreement;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Amyloid;Amyloid beta-Protein;amyloid imaging;AN-1792;Anaphylatoxins;Anti-Inflammatory Agents;Antibodies;Anticoagulants;apolipoprotein E-3;apolipoprotein E-4;Area;Autopsy;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood coagulation;Blood Vessels;blood-brain barrier crossing;Brain;Brain Edema;brain magnetic resonance imaging;Cerebral Amyloid Angiopathy;cerebral microbleeds;cerebrovascular;Cerebrovascular system;Cessation of life;Clinical;clinical development;Clinical Trials;Complement;Complement 5a;Consultations;Deposition;Dose;Effector Cell;Event;Gelatinase A;Gelatinase B;Gelatinases;Genotype;Hemorrhage;Human;Image;Immunize;Immunotherapy;Impaired cognition;Impairment;Incidence;Individual;Inflammatory;inhibitor;interest;intravenous administration;Letters;lipoxin A4;Lymphocyte;Macrophage;Meningoencephalitis;Methods;Molecular;Monoclonal Antibodies;mouse model;Mus;Myeloid Cell Activation;neuropathology;novel;novel strategies;old mice;Participant;Passive Immunotherapy;Pathologic;Pathology;Patients;Persons;Pharmaceutical Preparations;Phase;Population;prevent;Psyche structure;Publishing;Reporting;Resolution;response;Risk;Role;SB 3CT compound;Senile Plaques;T-Lymphocyte;Therapeutic Intervention;Transgenic Mice;vaccine trial;Vaccines;Vascular Diseases;vasogenic edema

PROJECT_TITLE: Adverse Cerebrovascular Responses to Antibodies Targeting Beta-Amyloid

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-M (91)]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: DALLAS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative Imbalances in lipid homeostasis can deleteriously impact health and therefore cells within the organism tightly regulate absorption, synthesis, and metabolism to accommodate energetic demands and ensure energetic reserves later in life. My laboratory has identified a mechanism by which cells sense intracellular lipid depletion and respond to metabolic demand. Activation and attenuation of this lipid surveillance response is regulated by the starvation-responsive nuclear hormone receptor, NHR-49, and a series of co-factors which mediate its vesicular release, nuclear import, intranuclear retention, and transcriptional activity followed by its phosphorylation, nuclear export and proteasomal degradation.

PI_NAMEs: DOUGLAS, PETER MAHAN (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: absorption;Architecture;Attenuated;attenuation;Binding;Binding Sites;Biological Assay;Carbon;casein kinase;Catabolism;Cell Nucleus;Cells;Chromatin;cofactor;Complex;Consensus;Coupled;Data;DNA;Endocytic Vesicle;Ensure;Expenditure;experimental study;fitness;Gene Expression;Genetic Transcription;Goals;Health;Histone Deacetylase;Homeostasis;In Situ Hybridization;In Vitro;in vivo;in vivo evaluation;Karyopherins;Laboratories;Life;Life Cycle Stages;Ligand Binding;Ligands;Lipids;Lysine;Mass Spectrum Analysis;Mediating;Membrane;Metabolic;Metabolism;Mitogen-Activated Protein Kinases;Mitogens;Molecular;Monitor;multimodality;Mutation;Mutation Analysis;Nuclear;Nuclear Export;Nuclear Hormone Receptors;Nuclear Import;Nuclear Pore;Nuclear Pore Complex;Nuclear Translocation;nucleocytoplasmic transport;nutrient absorption;Organism;Pathway interactions;Peptides;Phosphorylation;Phosphotransferases;Physiology;Pore Proteins;Post-Translational Protein Processing;protein degradation;receptor;reconstitution;Regulation;Reporting;Research;response;restoration;RNA interference screen;Role;screening;Series;Signal Transduction;Starvation;Techniques;trafficking;Transcriptional Activation;Transcriptional Regulation;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;Vesicle;vesicular release;Work

PROJECT_TITLE: Multimodal regulation of intracellular lipid surveillance

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences;Substance Misuse;Women's Health Research

ORG_CITY: OXFORD

ORG_DEPT: PSYCHOLOGY

ORG_NAME: MIAMI UNIVERSITY OXFORD

ORG_STATE: OH

PHR: Project Narrative Sex differences in vulnerability to alcohol suggest that alcohol drinking behaviors are influenced by different mechanisms in males and females. This project will use mouse models of alcohol consumption to investigate the contribution of X chromosome genes to drinking behaviors. Interactions with gonadal sex and alcohol exposure will also be explored. Understanding the neural mechanisms that drive differences in alcohol consumption will inform future therapies and treatments for Alcohol Use Disorder.

PI_NAMEs: RADKE, ANNA KAY (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Abstinence;alcohol abuse therapy;Alcohol consumption;alcohol exposure;alcohol measurement;alcohol use disorder;Alcohols;Animals;antagonist;Automobile Driving;Behavior;behavior influence;Brain;brain tissue;Candidate Disease Gene;candidate identification;Chromosomes;Consumption;Corpus striatum structure;Data;Dopamine Receptor;dosage;Dose;drinking;drinking behavior;Estradiol;experience;experimental study;Female;Four Core Genotypes;frontal lobe;Future;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Gender;Gene Expression;Gene Modified;gene product;gene repression;Genes;Genetic;Genetic Transcription;genotypic sex;Gonadal Hormones;Gonadal Steroid Hormones;GPRASP1 gene;Human;innovation;interest;knock-down;Link;male;Mediating;Mediator;men;Methods;mouse model;Mus;neuromechanism;novel;Operative Surgical Procedures;Ovary;overexpression;Persons;pharmacologic;Ploidies;pre-clinical research;preference;prevent;programs;Publishing;Qualifying;Recording of previous events;Regulation;Research;Reverse Transcriptase Polymerase Chain Reaction;Role;sex;Sex Chromosomes;Sex Differences;Site;Testing;Testis;Therapeutic;Treatment Efficacy;Woman;Work;X Chromosome;X Inactivation

PROJECT_TITLE: Sex chromosome contributions to alcohol drinking behaviors

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Pulmonary Hypertension;Rare Diseases

ORG_CITY: MADISON

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE Pediatric cardiovascular and respiratory diseases, including congenital heart diseases, lung disease of prematurity, and cystic fibrosis, require multiple imaging studies to evaluate the cardiovascular and pulmonary systems, but this is currently done in separate scans that are very long and labor intensive. This project aims to develop MRI methods for integrated cardiopulmonary evaluation in pediatrics, including advances in MRI hardware, data acquisition, and image reconstruction, that will provide anatomical and functional information in a single, rapid scan. This will improve the diagnosis, treatment selection, and monitoring of cardiopulmonary diseases in pediatrics, and also will improve our fundamental understanding of the interaction between the cardiovascular and pulmonary systems, all without the use of ionizing radiation.

PI_NAMEs: JOHNSON, KEVIN MICHAEL (contact);LARSON, PEDER ERIC ZUFALL;LUSTIG, MICHAEL ;VASANAWALA, SHREYAS S

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Abdomen;Adult;Age;anatomic imaging;Anatomy;Biological Markers;Breathing;bulk motion;Cardiac;cardiac magnetic resonance imaging;Cardiopulmonary;cardiopulmonary system;Cardiovascular Diseases;Cardiovascular system;Chest;Child;Childhood;Chronic lung disease;Clinical Management;clinical translation;Collaborations;Complex;congenital heart abnormality;cost;Coupled;Coupling;Cystic Fibrosis;Data;data acquisition;deep learning;deep learning model;Development;Diagnosis;Diagnostic;diagnostic tool;Dimensions;Disease;Evaluation;flexibility;Frequencies;Future;Goals;Heart;Heart Diseases;heart function;heart motion;hemodynamics;high dimensionality;Image;image reconstruction;imaging modality;imaging study;improved;Individual;innovation;Ionizing radiation;Learning;Link;Logistics;Lung;Lung Diseases;lung imaging;Magnetic Resonance Imaging;Measures;Methods;microwave electromagnetic radiation;Modality;Monitor;Morphologic artifacts;Motion;National Heart, Lung, and Blood Institute;next generation;novel;Operative Surgical Procedures;Outcome;Participant;Pathology;Patient Care;Patients;pediatric patients;Pediatrics;Performance;Perfusion;Phase;Physiologic pulse;Physiological;premature;prognostic tool;pulmonary function;Pulmonary Heart Disease;Pulmonary Hypertension;pulmonary vascular remodeling;Pulmonary Ventilation;quantitative imaging;Radionuclide Imaging;reconstruction;repaired;Resolution;respiratory;Respiratory Disease;Respiratory System;Right Ventricular Dysfunction;Right Ventricular Function;Risk;Running;Sampling;Scanning;Secondary to;Selection for Treatments;Signal Transduction;single photon emission computed tomography;Site;Speed;standard of care;structural imaging;Structure;System;Techniques;technology development;Time;tool;Translating;Treatment Failure;ultrasound;Validation;Vascular blood supply;Vascular System;ventilation;Ventricular;Visit

PROJECT_TITLE: Pediatric Cardiopulmonary MRI using RF Navigators and High Dimensional Deep Learning

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative This project aims to investigate the role of glycogen metabolism in the progression of Ewing's Sarcoma, a rare and aggressive form of bone and soft tissue cancer. By elucidating the molecular mechanisms governing glycogen metabolism in tumor cells, we seek to identify novel diagnostic, prognostic, and therapeutic targets. The outcomes of this research have the potential to significantly advance our understanding of Ewing's Sarcoma and contribute to the development of more effective treatment strategies for affected patients.

PI_NAMEs: GENTRY, MATTHEW S.;SUN, RAMON C. (contact)

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: 5'-AMP-activated protein kinase;Adjuvant Therapy;Affect;Apoptosis;Bioenergetics;Biomass;Biopsy;Bone Tissue;Carbohydrates;care outcomes;Cell Cycle;Cell Line;Cells;chemotherapy;Chemotherapy-Oncologic Procedure;Child;Childhood;Clinic;Clinical;Clinical Trials;clinically actionable;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Colon;combat;Complex;Cytoplasmic Granules;Data;Development;Diagnostic;dimension reduction;Disease;Ectopic Expression;effective therapy;Enzymes;Ewings sarcoma;Foundations;Genetic;Glucan 1,4-alpha-Glucosidase;Glycogen;Glycogen (Starch) Synthase;glycogen metabolism;Goals;Growth;Guaiacol;Heterogeneity;high dimensionality;Image;improved;In Situ;in vivo;inhibitor;Investigation;Knock-out;Knowledge;knowledge base;Link;Lung;machine learning pipeline;Malignant Bone Neoplasm;Malignant Neoplasms;mass spectrometric imaging;Metabolic;Metabolic Pathway;Metabolism;Metastatic Ewing's Sarcoma;Metformin;Methodology;Modeling;Molecular;mouse model;Neoplasm Metastasis;neoplastic cell;novel diagnostics;Nude Mice;Outcome;Outcomes Research;Pathology;Pathway interactions;Patient Care;Patients;Periodic acid Schiff stain method;personalized medicine;pharmacologic;Polysaccharides;prevent;Primary Neoplasm;prognostic;Proliferating;prospective;Prostate;Recurrence;Reporting;research and development;Resolution;Role;Sampling;Scientist;Site;small molecule;soft tissue;Specimen;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;stable isotope;synergism;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Tissues;treatment strategy;tumor;Tumor Biology;tumor growth;tumor metabolism;tumor microenvironment;tumor progression;tumorigenesis

PROJECT_TITLE: Targeting Glycogen Metabolism in Ewing's Sarcoma: Diagnostic, Prognostic, and Therapeutic Applications

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE The Texas Medical Center (TMC) Genomics Center for Infectious Disease (GCID) combines genomic sequencing technology, organoid cultures and clinical expertise to study host-mucosal pathogen interactions in human tissues, aiming to identify therapeutic and diagnostic targets. Four research projects will focus on Enterobacteriaceae colonization and translocation, norovirus and respiratory syncytial virus analysis and evolution from patient samples, the impact of Candida albicans strains on gut health, and the prevention of Cryptosporidium infection with novel metabolites. The ultimate goal is to gain a comprehensive understanding of genetic profiles and host responses to develop precise treatments for various infectious diseases covered in the TMC-GCID.

PI_NAMEs: ESTES, MARY KOLB;GIBBS, RICHARD A;MARESSO, ANTHONY W;PETROSINO, JOSEPH FRANK (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Bacteria;Bacterial Infections;Biology;Blood Circulation;Cancer Center;Candida albicans;Cell Death Induction;Cells;Childhood;Cities;Clinical;clinically relevant;college;commensal microbes;Communicable Diseases;computational pipelines;Country;Cryptosporidiosis;Cryptosporidium;Diagnostic;Disease;Disease Outcome;Doctor of Philosophy;Drug resistance;Ecosystem;Elements;Enterobacteriaceae;Epithelial Cells;Epithelium;Equilibrium;Evolution;experience;Funding;fungus;gastrointestinal;Gastrointestinal tract structure;Genetic;Genetic Determinism;genetic profiling;Genetic Recombination;Genetic Transcription;genetic variant;Genetic Variation;Genome;Genomic Centers for Infectious Diseases;Genomics;Genotype;Goals;gut health;gut homeostasis;gut microbiome;Health;High-Throughput Nucleotide Sequencing;host microbiome;host microbiota;Human;human model;human mortality;human tissue;Immune response;improved;Individual;Indoles;Infection;Infection prevention;Innate Immune Response;Institution;Integration Host Factors;Intestinal Mucosa;Intestines;Knowledge;Leadership;Length;Libraries;Life;Lung;Machine Learning;Mammals;Maps;Medical center;medical schools;Medicine;member;Metagenomics;metatranscriptomics;Microbe;microbial community;microbial genome;microbial genomics;microbiome;Modeling;Molecular;Mucous Membrane;multidisciplinary;Norovirus;novel;novel diagnostics;novel therapeutics;novel vaccines;Organoids;Outcome;Output;Parasites;Parasitic infection;pathogen;Pathogenesis;Pathogenicity;patient subsets;Patients;Pharmaceutical Preparations;Phenotype;Physicians;Physiological;Piedra;Play;precision medicine;Predisposition;prevent;Prevention;Preventive;Public Health Schools;pulmonary function;real time model;Request for Applications;Research Project Grants;Resistance;Resources;Respiratory syncytial virus;Respiratory System;response;Rice;Role;Sampling;Scientist;Site;Skin;Societies;Sum;Surface;synergism;Systemic infection;Technology;Testing;Texas;Therapeutic;tool;transcriptomics;transmission process;United States National Institutes of Health;Universities;University of Texas M D Anderson Cancer Center;Vaccines;Viral;Viral Respiratory Tract Infection;Virulence;Virulence Factors;Virus;Virus Replication;waterborne;Work

PROJECT_TITLE: Integrated Genomics of Mucosal Infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 MFH-M (J1)]


NIH_SPENDING_CATS: Infectious Diseases

PI_NAMEs: PETROSINO, JOSEPH FRANK (contact)

PROJECT_TERMS: Accountability;Accounting;Administrator;Advisory Committees;Annual Reports;Award;Awareness;Budgets;college;Communication;Communities;Coordination and Collaboration;cost;Data;design;Educational workshop;Ensure;Expenditure;Financial Activity;Fostering;Funding;Funding Agency;Genomic Centers for Infectious Diseases;Genomics;Goals;Grant;Infection;innovation;Institution;Intellectual Property;International;Laboratories;Leadership;lectures;Legal patent;Logistics;Manuscripts;material transfer agreement;Medical center;Medicine;meetings;member;Metagenomics;microbiome research;Monitor;Mucous Membrane;National Institute of Allergy and Infectious Disease;Office of Administrative Management;operation;outreach;Participant;Pilot Projects;Probability;Problem Solving;Process;programs;Progress Reports;Property Rights;Publications;Publishing;Reagent;Recommendation;Records;Reporting;Research;Research Personnel;Research Project Grants;Resource Allocation;Resource Sharing;Rest;Rights;Schedule;Scientific Advances and Accomplishments;Series;Services;Specific qualifier value;success;synergism;System;Technology;Texas;timeline;tool;Travel;United States National Institutes of Health;webinar

PROJECT_TITLE: Administrative Core


PI_NAMEs: MUZNY, DONNA  (contact)

PROJECT_TERMS: Address;analytical method;Antibiotic Resistance;Antibodies;Bacteria;Bacterial Genome;Bioinformatics;bioinformatics tool;Biomass;Cells;Collaborations;college;Communicable Diseases;Communities;Complex;cost;cost effective;cost efficient;Data;Data Analyses;data dissemination;data management;data quality;Data Set;data sharing;Development;Diagnosis;Elements;Ensure;experience;fungus;Generations;Genes;genetic makeup;Genetic Polymorphism;Genetic Predisposition to Disease;Genome;Genomic approach;Genomic Centers for Infectious Diseases;genomic data;Genomic medicine;Genomics;Goals;heterogenous data;High-Throughput DNA Sequencing;Human Genetics;human genome sequencing;Human Microbiome;improved;Individual;Infection;Infectious Agent;infectious disease treatment;Infectious Diseases Research;Informatics;innovation;insight;Intake;interest;Knowledge;Laboratories;Length;Libraries;Management Information Systems;Medical center;Medicine;Metagenomics;method development;Methodology;Methods;Microbe;microbial;microbiome;microbiome research;Mission;Modality;Molecular;Mucous Membrane;multiple omics;nanopore;National Institute of Allergy and Infectious Disease;new technology;next generation sequencing;novel;novel sequencing technology;novel strategies;Nucleic Acids;open source;Output;outreach;parasite genome;Parasites;pathogen;pathogen genomics;Pathogenesis;Pharmaceutical Preparations;Policies;Preparation;Production;Program Development;programs;Protein Isoforms;protein profiling;Protocols documentation;public database;public repository;reference genome;Research;Research Personnel;Research Project Grants;resistance gene;Resolution;Resource Sharing;Resources;response;Sampling;secondary analysis;sequencing platform;Signal Transduction;single-cell RNA sequencing;software development;Specimen;Techniques;Technology;technology development;Texas;tool;tool development;Transcript;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Vaccines;Viral;Virulence;Virulence Factors;Virus;web site;Work

PROJECT_TITLE: Sequencing Analysis and Resource Dissemination core


PI_NAMEs: BLUTT, SARAH E (contact)

PROJECT_TERMS: Address;Aerobic;Affect;Age;airway epithelium;Animal Model;Animals;antimicrobial;bacterial genetics;beneficial microorganism;Biological;Biological Models;Biology;Categories;Cell Line;cell type;Cessation of life;Collaborations;Communicable Diseases;Communication;Complex;cost;cost effective;Cost Savings;design;Disease;Elements;emerging pathogen;Ensure;Environment;Epithelium;Equipment;Ethnic Origin;Evolution;experimental study;Fortification;Freezing;Functional disorder;Funding;Genes;genome sequencing;Genomic Centers for Infectious Diseases;Genomics;Goals;Growth Factor;Human;Immune response;improved;Individual;Infection;intestinal epithelium;Intestines;Invaded;Knowledge;Leadership;Measures;microbial;microbial community;microbiome;microorganism interaction;Modeling;Mucous Membrane;mutant;National Institute of Allergy and Infectious Disease;Organ Donations;Organism;Organoids;Outcome;pathogen;Pathogenesis;pathogenic microbe;Pathogenicity;Patients;Physiological;Play;prevent;programs;Psychological reinforcement;Reagent;Reproducibility;Research;Research Personnel;resident commensals;response;Sampling;sex;Standardization;stem cells;Study models;success;Surface;Symbiosis;Technology;Technology Transfer;Testing;Time;Tissues;tool;translational genomics;United States National Institutes of Health;Validation;Viral

PROJECT_TITLE: Organoid and Minibioreactor Array Cultivation Core


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Machine Learning and Artificial Intelligence;Microbiome;Prevention

PHR: Project Narrative This proposal will investigate how antimicrobial resistant bacteria move from the gastrointestinal tract into the bloodstream, which is a significant cause of morbidity and mortality worldwide. The project will utilize genome sequencing, organotypic culture models, machine learning, and transcriptional analysis to uncover key factors involved in the process. The findings will contribute to the development of vaccines and therapeutics to prevent and treat bacterial infection.

PI_NAMEs: MARESSO, ANTHONY W (contact)

PROJECT_TERMS: Address;Adherence;Antimicrobial Resistance;Apical;Back;Bacteria;Bacterial Adhesins;Bacterial Infections;bacterial resistance;Bioreactors;Biota;Blood;Blood Circulation;Clinical;college;commensal microbes;Communities;Computer software;Data;Disease;Elements;Enterobacteriaceae;Environment;Epithelium;Etiology;Family;Friends;functional genomics;Funding;Gastrointestinal tract structure;gene network;Genes;genetic approach;genetic element;Genetic Polymorphism;Genetic Transcription;Genome;genome sequencing;genome-wide;genomic data;Genomics;gut microbiota;Host Defense;Human;human microbiota;Immune response;Infection;Intestinal Mucosa;Intestines;Knowledge;Libraries;Machine Learning;Maps;Medical center;Medicine;microbiome;microbiota;Modeling;Morbidity - disease rate;mortality;Movement;Mucous Membrane;neural network;novel;novel vaccines;Organ;Organoids;pandemic disease;pathogen;pathogenic bacteria;Pathogenicity;Phenotype;Physiological;Population;Predisposition;prevent;probiotic therapy;Process;public database;reference genome;Reporting;Research;resident commensals;response;reverse genetics;Rice;Risk Factors;Sampling;Sequence Analysis;Superbug;Surface;synergism;Systemic infection;Technology;Testing;Therapeutic;tool;Training;Universities;user-friendly;vaccine development;Virulence

PROJECT_TITLE: Functional Genomics of Pathogenic Enterobacteriaceae


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Lung;Microbiome;Pediatric;Prevention;Vaccine Related

PI_NAMEs: ATMAR, ROBERT L. (contact)

PROJECT_TERMS: Accident and Emergency department;Acute;Acute respiratory infection;Affect;Age;Anti-viral Therapy;Bacteria;Biological;Biological Markers;Bioreactors;burden of illness;Categories;Category B pathogen;Category C pathogen;Cessation of life;Child;Child health care;Childhood;Circulation;Clinical;Clinical Trials;clinically relevant;Coculture Techniques;Collaborations;college;COVID-19 pandemic;Development;diagnostic biomarker;Disease;Dose;Economic Burden;enteric pathogen;Epidemiology;Epithelium;ethnic diversity;Event;Evolution;Feasibility Studies;Feces;Funding;Gastroenteritis;gastrointestinal;Gastrointestinal Diseases;gastrointestinal infection;Genetic;Genetic Recombination;Genetic Transcription;Genome;genome analysis;genome repository;genomic data;Genomics;Goals;Health;Health Care Visit;Hospitals;host microbiome;Human;Immune;Immune response;Immunocompromised Host;implementation intervention;Infant;Infection;innovation;insight;Integration Host Factors;Intervention;Intestines;Length;Life;Machine Learning;Mediator;Medicine;Metadata;metagenomic sequencing;microbiome;Modeling;Modification;Monoclonal Antibodies;Morbidity - disease rate;mortality;Mucous Membrane;National Institute of Allergy and Infectious Disease;Norovirus;Nose;novel vaccines;Organoids;Outpatients;pandemic disease;pathogen;Pathogenesis;Pattern;Phase II/III Trial;Physiological;Population;Population Heterogeneity;post-pandemic;pre-pandemic;Predisposition;Premature Infant;pressure;priority pathogen;racial diversity;Research Personnel;Resources;respiratory;Respiratory Disease;respiratory pathogen;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Respiratory Tract Infections;response;Sampling;Sampling Studies;Seasons;Severity of illness;Shotguns;Single Nucleotide Polymorphism;Site;Specimen;Subgroup;success;surveillance network;Time;Transcript;transcriptome;transcriptomics;vaccine candidate;Vaccines;Validation;Variant;Viral;virome;Virulence;Virus;Virus Diseases;virus host interaction;Virus Shedding;Virus-like particle;whole genome

PROJECT_TITLE: Viral Diversity and Pathogenesis of Mucosal Gastrointestinal and Respiratory Infections


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Genetics;Human Genome;Infectious Diseases;Microbiome

PHR: Narrative The fungus Candida albicans causes significant morbidity and mortality, particularly among individuals with a debilitated immune system such as cancer patients receiving chemotherapy or transplant recipients. A common source of these life-threatening Candida infections is the gastrointestinal tract of the same patients. We will collect, sequence, and study a large set of C. albicans strains derived from the human intestine to establish the spectrum of interactions between intestinal mucosa and fungus.

PI_NAMEs: LORENZ, MICHAEL C (contact)

PROJECT_TERMS: Adhesions;Adult;Alleles;Automobile Driving;Biology;Cancer Patient;Candida;Candida albicans;Candidate Disease Gene;candidate identification;Candidiasis;cell type;Cells;chemotherapy;Clinical;Collection;college;Communities;Data;Developed Countries;Disease;Environment;fitness;Fungal Genes;fungal genetics;fungus;Gastrointestinal tract structure;Gene Expression;Gene Expression Profile;Genes;genetic analysis;Genetic Markers;genetic variant;Genetic Variation;Genome;Genomics;gut colonization;Health Sciences;Hospitals;Host Defense;Human;Hyphae;Immune system;Immunologics;Individual;Infection;Information Dissemination;insight;intestinal epithelium;Intestinal Mucosa;Intestines;Invaded;Knowledge;Libraries;Life;Mediating;Medical;Medical center;medical schools;Medicine;Methodist Church;Minority;Molecular;Molecular Profiling;Morbidity - disease rate;mortality;mouse model;Mucous Membrane;Mus;Mycoses;neglect;Occupations;Organoids;pan-genome;pathobiont;Pathway interactions;Patients;Phenotype;Population;population based;reference genome;Research;Research Institute;Resources;response;reverse genetics;Risk;Role;Site;Source;Technology;Testing;Texas;Transcript;transcriptome;transcriptomics;Transplant Recipients;United States;Universities;user-friendly;virtual

PROJECT_TITLE: Genomic and Phenotypic Diversity of a Human Gut Fungal Pathobiont


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Machine Learning and Artificial Intelligence;Mental Health;Recovery Support Services;Substance Misuse;Telehealth

ORG_CITY: PULLMAN

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Project Narrative Alcohol use disorder (AUD) is a serious public health problem, and early stages of AUD recovery are fragile such that significant proportion of individuals who seek treatment will relapse within the first few months after treatment. Stressful events can contribute to relapse and effective interventions during early stages of AUD recovery that can support stress reduction are critical. Implementing a cost-effective, and novel music-based intervention to support stress management and emotion regulation during recovery will reduce the burden associated with AUD.

PI_NAMEs: CLEVELAND, MICHAEL  (contact);HABIBI, ASSAL ;ZADEH, HASSAN GHASEM

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: acceptability and feasibility;Acoustics;acute stress;adaptive intervention;addiction;Address;Adherence;Adult;Aftercare;alcohol abuse therapy;alcohol availability;Alcohol consumption;alcohol use disorder;Alcohols;anxiety reduction;anxiety symptoms;Area;automated algorithm;biological adaptation to stress;Brain;Characteristics;chronic alcohol ingestion;cohort;coping;cost;cost effective;craving;Data;Data Analyses;depressive symptoms;design;Detection;Devices;dosage;Drug Metabolic Detoxication;early alcohol use;Ecological momentary assessment;effective intervention;efficacy trial;emotion regulation;Emotions;Environment;Exhibits;feasibility testing;Feedback;Foundations;Goals;Habits;Health Technology;Healthcare Systems;High Prevalence;Hour;Individual;innovation;Intervention;Interview;Libraries;Loudness;Machine Learning;machine learning algorithm;Methods;mHealth;mhealth interventions;mood regulation;Moods;Music;Music Therapy;Neurosecretory Systems;novel;Participant;Patient Self-Report;Perception;Personality;Phase;Physiologic Monitoring;Physiological;Physiological Processes;Population;Public Health;randomized trial;Recommendation;Recovery;recruit;Relapse;relapse prevention;relapse risk;remote delivery;remote intervention;remote technology;Reporting;Research;Rewards;Sampling;satisfaction;Scanning;sobriety;Stress;stress management;stress reduction;Stressful Event;Structure;System;Technology;theories;Time;tool;trend;United States;wearable data;wearable sensor technology;Work;young adult;Youth

PROJECT_TITLE: Developing a Music Listening mHealth Intervention for Stress Reduction in Early Recovery

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 MS (01)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Physical Activity;Prevention

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: RELEVANCE Although extended care promotes better weight loss maintenance (WLM) following initial weight management programs, conventional WLM interventions require significant effort and may fail to adequately support individuals' capacity to continue weight management efforts. By leveraging the multiphase optimization strategy framework and a factorial experimental design, this project includes an optimization trial to test four extended care intervention components designed to be “minimally disruptive” (i.e., effective treatments designed to limit burden): 1) reduced food variety, 2) home-based resistance training, 3) buddy training and support, and 4) acceptance and commitment therapy workshops. The goal is to develop an optimized intervention package that maximizes WLM and improves the public health impact of behavioral weight management interventions.

PI_NAMEs: DUTTON, GARETH R (contact)

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: Adherence;Adult;Aerobic Exercise;Aftercare;Age;Attenuated;Behavior;behavior change;Behavior Therapy;Behavioral;Black race;Body Weight decreased;Caloric Restriction;Characteristics;Clinical;confirmatory trial;design;Development;dietary;Disease Management;disorder prevention;disparity reduction;Dose;Eating;Educational workshop;effective therapy;Energy Intake;Evaluation;evidence base;Exclusion;Exercise;Experimental Designs;Food;Future;Goals;Habits;Home;improved;Individual;Intervention;intervention effect;Long-Term Care;Maintenance;Mediating;Mediator;mindfulness;Modality;Modification;Monitor;Motivation;multiphase optimization strategy;novel;obesity treatment;Outcome;Participant;Phase;Physical activity;primary outcome;programs;psychologic;Psychosocial Factor;Psychosocial Influences;Public Health;Race;Randomized;Randomized, Controlled Trials;Readiness;Recommendation;Research;resistance exercise;Resources;Self Efficacy;skills training;Social Network;Social support;Specific qualifier value;Testing;theories;therapy design;Time;Training;treatment adherence;treatment effect;treatment optimization;treatment response;Weight;weight loss program;Weight maintenance regimen

PROJECT_TITLE: Optimizing an extended care intervention to promote weight loss maintenance

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Social Determinants of Health;Telehealth;Violence Research

ORG_CITY: CHESTNUT HILL

ORG_NAME: BOSTON COLLEGE

ORG_STATE: MA

PHR: PROJECT NARRATIVE Mental disorders are leading causes of the health-related burden globally, and in Rwanda the intergenerational mental health consequences of the 1994 Genocide against the Tutsi persist and are further compounded by poverty, such that recent studies have found 20% of the Rwandan population has one or more mental disorders. The proposed research will test the feasibility, acceptability and impact of a technology-enabled service delivery model using a digital tool that streamlines data collection, improves visibility of key program performance metrics, and serves as a resource for learning materials that can be used for continuous learning and training of a non-specialized workforce that is delivering an evidence-based intervention that improves caregiver mental health and family functioning. What we learn from technology-supported delivery of Sugira Muryango – an evidence-based, trauma-informed, family-based behavioral intervention in Rwanda – can be used to improve the efficiency, effectiveness, and scalability of evidence-based mental health services in Rwanda and globally.

PI_NAMEs: BETANCOURT, THERESA STICHICK (contact);DESMOND, CHRIS ;KUMAR, PRAVEEN ;MCTERNAN, MELISSA ;SEZIBERA, VINCENT

PROGRAM_OFFICER_NAME: CUBILLOS, LEONARDO

PROJECT_TERMS: Acceleration;Adoption;Adult;Affect;Behavior Therapy;Behavioral;beneficiary;burden of illness;Caregivers;Characteristics;Child;Child Development;Child Mental Health;child protection;Child Rearing;Cluster randomized trial;Communication;Communities;Competence;cost effective;cost effectiveness;dashboard;Data;Data Collection;density;design;Development;digital;digital tool;early childhood;Effectiveness;effectiveness/implementation study;Ego;Emotional;evidence base;Evidence based intervention;Evidence based practice;experience;Family;Family Violence;feasibility testing;follow-up;Frequencies;Genocides;Government;Health;health knowledge;Hybrids;implementation science;implementation/effectiveness;improved;incremental cost-effectiveness;Infrastructure;intergenerational;Intervention;intervention delivery;Investments;Knowledge;knowledge network;Learning;learning materials;learning progression;Link;Measures;Mental disorders;mental function;Mental Health;Mental health promotion;Mental Health Services;mHealth;offspring;Outcome;Outcome Measure;Ownership;Pathway Analysis;Pathway interactions;peer;Performance;Policies;Population;Poverty;poverty reduction;Problem behavior;Program Acceptability;Program Effectiveness;programs;Readiness;referral services;Research;Resolution;Resources;Risk;Rwanda;Self Efficacy;Service delivery model;Site;skills;social;Social Network;Social Protection;Social Work;Structure;Survivors;Techniques;Technology;Testing;Time;tool;Training;Trauma;Universities;Violence;volunteer;War

PROJECT_TITLE: Testing an mHealth Digital Dashboard to improve Quality of Delivery of Evidence-based Interventions that Promote Family Mental Health and Functioning in Rwanda.A Hybrid Type 3 Study.

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Lung;Neurosciences;Sleep Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: NARRATIVE Obstructive sleep apnea (OSA), the most common sleep disorder, is caused by repeated disruption of airflow (apneas) leading to decreased blood oxygenation, resulting in daytime sleepiness and impaired vigilance. This project uses novel imaging methodology to study the adverse effects of OSA on the brain along with measurement of airway obstruction. The results should provide new insight into the disorder and aid in designing improved forms of treatment.

PI_NAMEs: WEHRLI, FELIX W (contact)

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: Acoustics;Acute;Adverse effects;Air Movements;airway obstruction;Anatomy;Apnea;awake;Biological;Biological Markers;Blood;Blood Vessels;Body Weight decreased;Brain;brain based;brain metabolism;Cardiac;Cell Respiration;Cerebrum;Chronic;cognitive function;Cues;Data;Deglutition;Dependence;design;Detection;Development;Disease;Drowsiness;Electroencephalography;endothelial dysfunction;Event;event cycle;Exposure to;Foundations;Future;Heart Diseases;Hypertension;Hypoxemia;Hypoxia;Hypoxic Brain Damage;Image;image translation;Imaging Techniques;Impaired cognition;Impairment;improved;Individual;innovation;insight;Location;Magnetic Resonance Imaging;Maps;Measurement;Measures;Metabolic;Metabolic Diseases;metabolic profile;metabolic rate;Metabolism;Methodology;Methods;Modeling;Monitor;Morphology;multimodality;Nerve Degeneration;neuroinflammation;neurovascular;noise exposure;novel;Obstruction;Obstructive Sleep Apnea;Operative Surgical Procedures;Oral;organ injury;Oropharyngeal;Oxidative Stress;Oxygen;Oxygen saturation measurement;Pathogenesis;Patients;Persons;Phase;Phenotype;Physiological;Plethysmography;Prevalence;Process;Protocols documentation;Research;Research Personnel;Resolution;Respiration;response;Rest;Risk;Risk Factors;Scanning;Severities;Severity of illness;Sleep;Sleep Disorders;Sleep Stages;soft tissue;Stroke;Structure;Structure-Activity Relationship;Technology;temporal measurement;Testing;Therapeutic;Time;Up-Regulation;Variant;vigilance;Visualization;Wakefulness;Work

PROJECT_TITLE: Time-Resolved MRI Method for EEG Assisted Concurrent Mapping of Cerebral Oxygen Metabolism and Airway Structure in Obstructive Sleep Apnea

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Nanotechnology;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: LEXINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative Tissue regeneration after spinal cord trauma is limited by additional biological events including inflammation, which induce an inhibitory local microenvironment leading to cellular death and functional deficits. lmmunotherapeutic nanoparticles with different physicochemical factors without using active pharmaceutical ingredients interact with circulating immune cells and reprogram their function to mitigate inflammation and modify the microenvironment in favor of regeneration. The proposed studies will identify crucial parameters of nanoparticles for the development of effective nanotherapeutics which will contribute to the development of potentially effective practical therapy for spinal cord trauma.

PI_NAMEs: PARK, JONGHYUCK  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acids;Acute;Affect;Anatomy;Anti-Inflammatory Agents;Artificial nanoparticles;Axon;axon regeneration;Biocompatible Materials;Biodistribution;Biological;Biological Process;Biological Products;Blood;Cell Death;Cells;Cessation of life;Chronic Phase;Circulation;clinical application;Data;Demyelinations;design;Development;Diagnosis;Disease;Drug Kinetics;Engineering;Environment;Event;Extravasation;FDA approved;Female;Formulation;Functional disorder;Functional Regeneration;Gene Expression;Genes;Glucocorticoids;Goals;Growth;Immune;immune cell infiltrate;Immune response;immunoregulation;Immunotherapeutic agent;Individual;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Injury;Innate Immune System;Intervention;intravenous administration;Macrophage;male;Mediating;Methylprednisolone;minimally invasive;monocyte;nanoformulation;nanoparticle;nanopolymer;nanotherapeutic;Natural regeneration;neural;Neurons;neutrophil;novel strategies;novel therapeutics;Organ;Outcome;Patients;Pattern;peripheral blood;permissiveness;Pharmaceutical Preparations;Pharmacologic Substance;Phenotype;Physiological;Play;Polymers;Population;programs;Property;Recovery of Function;remyelination;Research;response;risk/benefit ratio;Role;Secondary to;sex;Sex Differences;Site;Spinal Cord;Spinal cord injury;Spleen;synaptogenesis;Testing;Therapeutic;therapeutic effectiveness;tissue injury;tissue regeneration;Tissues;tool;trafficking;Trauma;Triage

PROJECT_TITLE: Harnessing engineered drug-free polymeric nanoformulations to reprogram innate immune cells for spinal trauma

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Opioids;Pain Research;Patient Safety;Pediatric;Precision Medicine;Rehabilitation;Substance Misuse

ORG_CITY: DURHAM

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Despite two millennia of tonsillectomies and decades of research, we have failed to provide adequate pain relief and determine the optimal perioperative pain regimen for the 500,000 US children undergoing tonsillectomy annually. There is an urgent need to manage acute post-tonsillectomy pain both safely and effectively, particularly in an era when prescribing “take-home” opioids must be carefully considered due to the known risks of opioid-related harms in children and adolescents. In a single center randomized controlled clinical trial, we will identify the optimal age-specific, weight-based dose of intraoperative methadone, a long acting, cost-effective and widely available analgesic, to optimize pain management and reduce the need for postoperative opioids in children and adolescents undergoing tonsillectomy.

PI_NAMEs: EINHORN, LISA M. (contact)

PROGRAM_OFFICER_NAME: PILEGGI, ANTONELLO

PROJECT_TERMS: Absence of pain sensation;Acute;Acute Pain;Address;Adherence;Adolescent;Adult;Adverse event;Age;age related;Analgesics;Anesthesia procedures;Behavioral;Body Weight;Caregivers;Child;Child Care;Childhood;Chronic;Client satisfaction;Clinical Data;clinical effect;Clinical Pharmacology;clinical practice;cohort;comparative effectiveness;Consensus;cost effective;Data;Dose;Double-Blind Method;Ensure;Enteral;Goals;Guidelines;Half-Life;Home;Hospitals;Hour;improved;Individual;innovation;Inpatients;Intake;Intravenous;Knowledge;Medical;Medication Management;Methadone;Operative Surgical Procedures;Opioid;Opioid Analgesics;opioid sparing;opioid use;Outcome;Outcome Measure;Outpatients;Overdose;Pain;Pain intensity;Pain management;pain outcome;pain reduction;pain relief;pain score;Patients;Pediatric Surgical Procedures;Perioperative;Pharmaceutical Preparations;pharmacologic;Pharmacology;Population;Postoperative Pain;Postoperative Period;Practice Guidelines;precision medicine;Precision therapeutics;Predisposition;prescription opioid;Procedures;Property;prospective;Public Health;Randomized;Randomized Controlled Clinical Trials;Recommendation;Recovery;Recovery of Function;Regimen;Research;Risk;satisfaction;Schools;side effect;Sleep;success;Surgeon;surgical pain;Testing;Therapeutic;Therapeutic Uses;Time;Tonsillectomy;Vulnerable Populations;Weight

PROJECT_TITLE: Revolutionizing Pediatric Tonsillectomy Pharmacology and Therapeutics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (81)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Regenerative Medicine

ORG_CITY: STANFORD

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Optic nerve damage and retinal ganglion cell loss is common to many eye diseases, including glaucoma and ischemic optic neuropathies. There are, however, no therapies that specifically promote retinal ganglion cell survival or axon regeneration in these diseases. A better understanding of the cellular mechanisms that impact neuroprotection and axonal regeneration may yield better therapeutic regimens, decreasing morbidity and potentially restoring vision.

PI_NAMEs: GOLDBERG, JEFFREY L;KAPILOFF, MICHAEL SETH (contact)

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: Acute;Alternative Splicing;Automobile Driving;Axon;axon growth;axon regeneration;Biological Assay;Ca(2+)-Calmodulin Dependent Protein Kinase;Cell Physiology;Cell Separation;Cell Survival;Cells;Chimeric Proteins;Chromatin;constitutive expression;CREB1 gene;Crush Injury;Cyclic AMP-Dependent Protein Kinases;Cyclic AMP-Responsive DNA-Binding Protein;Data;Dependovirus;Development;Disease;excitotoxicity;experimental study;Eye diseases;Gene Expression;Genes;genome-wide;Glaucoma;Goals;Image;in vivo;insight;Ischemic Optic Neuropathy;Knock-out;knockout gene;Knockout Mice;Maintenance;Mammals;Mediating;Morbidity - disease rate;mouse model;Mus;N-Methylaspartate;Nerve Crush;nerve damage;neuroprotection;novel therapeutic intervention;Nuclear;Optic Nerve;optic nerve disorder;Optic Nerve Injuries;Peptides;Phosphorylation;preservation;Process;protein activation;Protein Isoforms;ratiometric;Regimen;Regulatory Element;Reporter;Repression;Retina;retinal damage;retinal ganglion cell regeneration;Retinal Ganglion Cells;Role;sensor;sight restoration;Signal Transduction;single-cell RNA sequencing;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;transcription factor;Transcriptional Regulation;Transposase

PROJECT_TITLE: CaMKII: Retinal Ganglion Cell Neuroprotection and Axon Regeneration

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Radiation exposure is a major concern for CT imaging. Photon counting detectors provide ample opportunity for reducing radiation exposure, but systems today have not capitalized on this opportunity because it requires redesign of existing CT scanner components. Our work will lay the theoretical foundation and provide experimental demonstration of new scanner components that will allow future photon counting CT scanners to reduce radiation exposure without reducing image quality.

PI_NAMEs: HSIEH, SCOTT SIGAO (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TERMS: absorption;Address;analog;Architecture;Back;Characteristics;Charge;Clinical;Clinical Protocols;Computed Tomography Scanners;Data;Data Set;design;Detection;detector;Development;Diagnostic;Discrimination;Dose;Educational process of instructing;Engineering;engineering design;Event;FDA approved;Foundations;Future;Future Generations;Generations;Geometry;Image;Imaging technology;improved;innovation;Iodine;Lesion;light weight;Long-Term Effects;Manufacturer;Marketing;Measures;Metals;Methods;Monte Carlo Method;next generation;Noise;novel;Patients;Penetration;Performance;photon-counting detector;Photons;Physiologic pulse;Population;Process;product development;Protocols documentation;quantum;Radiation Dose Unit;radiation effect;Radiation exposure;Residual state;Resolution;Roentgen Rays;Route;Scanning;sensor;signal processing;Signal Transduction;simulation;soft tissue;Source;spectrograph;Sum;System;Technology;Testing;theories;Thick;trend;two-photon;Work;X-Ray Computed Tomography

PROJECT_TITLE: Improving the dose efficiency of photon counting CT


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: TEMPE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE  Top-down contextual information modulates the processing of bottom-up auditory signals to improve hearing accuracy, but the neural mechanisms underlying this essential function remain unclear, especially at the earliest level of the central auditory system. Here we use modern in vitro and in vivo approaches in mice to examine the role of the massive top-down projection from the inferior colliculus to the dorsal cochlear nucleus and test the cellular and circuit mechanism that guide context-dependent filtering of bottom-up signals. This project may provide insight into ways to improve auditory perception when bottom-up signals are degraded due to hearing loss, as well as auditory processing disorders for which dysfunctional top-down modulation has been implicated.

PI_NAMEs: BALMER, TIMOTHY S (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Acoustic Nerve;Acoustics;Acute;Affect;Anatomy;Animals;Aphasia;Auditory;auditory pathway;Auditory Perception;Auditory Perceptual Disorders;auditory processing;Auditory system;awake;Axon;Back;Brain;Brush Cell;Cell Nucleus;cell type;Cells;Central Nervous System;Cochlea;Cochlear nucleus;Complex;Cues;Data;Detection;dorsal cochlear nucleus;Dyslexia;Electrophysiology (science);Environment;Feedback;Fiber;Frequencies;Fusiform Cell;Genetic;Glutamates;granule cell;Hearing;hearing impairment;Impairment;improved;In Vitro;in vivo;Inferior Colliculus;insight;Interneurons;Knowledge;Label;Location;Modernization;Morphology;Movement;Mus;neural;neural circuit;neuromechanism;Neurons;neurophysiology;Neurosciences;Noise;optogenetics;patch clamp;Pathway interactions;Perception;Persons;phenomenological models;Play;Population;preservation;Presynaptic Terminals;Process;Property;Resistance;response;Role;Sensory;sensory system;Shapes;Signal Transduction;Slice;sound;Synapses;Testing;Transgenic Mice;Work

PROJECT_TITLE: Top-down modulation of the dorsal cochlear nucleus

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative Children with medical complexity (CMC) are an extremely vulnerable population with significant morbidity and mortality risk, and methods to identify CMC for research or enrollment in clinical programs often rely on diagnostic codes. This proposal is motivated by the premise that the accuracy of these methods warrant more rigorous evaluation, and furthermore due to differences in access to healthcare and diagnostic evaluations for various patient populations, diagnostic codes may reflect broader historical and societal biases and disparities (as preliminary data suggests). We propose to evaluate the accuracy and potential bias of these methods to promote the most effective and equitable care of CMC, and the methods and findings likely will be generalizable to all patient classification systems based on diagnosis codes.

PI_NAMEs: FEUDTNER, JOHN CHRIS (contact)

PROGRAM_OFFICER_NAME: SAGATOV, ROBYN

PROJECT_TITLE: CCC EQUATE (Equitable Quantification And Task Evaluation)

STUDY_SECTION: HSVR

STUDY_SECTION_NAME: Healthcare Systems and Values Research[HSVR]


ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Molecular forces that modify chromosome structure are crucial for establishing gene activity that allow animals to learn and generate adaptive responses, yet the identity of these mechanisms remains obscure. Our data suggests that torsional stress generated during transcription propagates widely across the neuronal genome and could be a driving force for chromatin reconfiguration following neuronal stimulation. By mapping the distribution of torsional stress at high resolution, and studying how torsional stress impacts chromosome configuration in response to neuronal stimulation, this project will enhance fundamental knowledge of how DNA mechanics shapes genome function, and mismanagement of torsional stress could contribute to neurodevelopmental defects and various neurological diseases, including autism spectrum disorders.

PI_NAMEs: MADABHUSHI, RAM  (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: Active Sites;Adaptive Behaviors;Address;Affect;Animals;Architecture;ATAC-seq;autism spectrum disorder;Bicuculline;Camptothecin;Catalytic Domain;Chromatin;Chromatin Loop;chromatin remodeling;Chromatin Structure;chromosome conformation capture;Chromosome Structures;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;crosslink;Data;Defect;demethylation;Development;Disease;DNA;DNA Topoisomerases;DNA-Directed RNA Polymerase;driving force;Epigenetic Process;Escherichia coli;Etoposide;experience;Free Energy;Genes;Genetic Transcription;Genome;Genome Mappings;genome-wide;genomic locus;global run on sequencing;Hippocampus;Histones;in vivo;Incubated;insight;knock-down;Knowledge;learned behavior;Learning;Lentivirus Vector;Location;Maps;mechanical force;Mechanics;Mediating;meter;Methods;Methylation;Molecular;Mus;N-Methylaspartate;Nervous System Disorder;Neurons;Nucleosomes;Pattern;Poison;programs;promoter;Reporting;Research;Resolution;response;Role;Rotation;Shapes;Signal Transduction;Site;small hairpin RNA;Stimulus;Stress;Superhelical DNA;Testing;Time;Topoisomerase;Topoisomerase Inhibitors;Torsion;Transcriptional Activation;transmission process;Type I DNA Topoisomerases

PROJECT_TITLE: The impact of DNA supercoiling and topoisomerases on neuronal activity-dependent chromatin organization

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Kidney Disease;Organ Transplantation;Transplantation

PHR: PROJECT NARRATIVE Improving long-term kidney allograft survival remains a major unmet clinical need in kidney transplantation. Early detect and frequent monitoring of allograft injuries is critical to timely diagnosis and intervention for improved long-term outcomes. In this project, we will develop and validate a novel super-resolution ultrasound microvascular imaging technology for noninvasive, reliable, cost-effective, and frequent evaluation of kidney allograft injury.

PI_NAMEs: HUANG, CHENGWU  (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Affect;Algorithms;Allografting;Binding;Biopsy;Blood Vessels;Clinical;clinical imaging;clinical translation;computerized data processing;contrast enhanced;contrast enhanced computed tomography;Contrast Media;cost effective;Creatinine;density;Development;Diagnosis;diagnosis standard;Disease;Doppler Ultrasound;Early Diagnosis;Economics;efficacy evaluation;End stage renal failure;Evaluation;Follow-Up Studies;Functional disorder;Glomerular Filtration Rate;Goals;Histologic;Histology;Image;Imaging Device;Imaging Techniques;Imaging technology;improved;indexing;Individual;Injury;Intervention;Kidney;kidney allograft;Kidney Transplantation;Magnetic Resonance Imaging;Measurement;Measures;Medical;meter;Methods;Microbubbles;Monitor;Morphology;Noise;novel;Outcome;Pathology;Patient Recruitments;Patient Schedules;patient subsets;Patients;Performance;Perfusion;Pilot Projects;Play;post-transplant;Proteinuria;Quality of life;Random Allocation;Reproducibility;Research;Resolution;ROC Curve;Role;Scanning;Serum;Signal Transduction;social;Speed;Sum;Survival Rate;Technology;Testing;Time;tool;Toxic effect;Transplant Recipients;ultra high resolution;Ultrasonography;ultrasound;Urine;Validation

PROJECT_TITLE: Characterization of microvasculature in kidney transplant by super-resolution ultrasound imaging


NIH_SPENDING_CATS: Lung;Pulmonary Fibrosis

ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

ORG_STATE: CO

PHR: PROJECT NARRATIVE Pulmonary fibrosis is often a fatal condition that leads to progressive scarring of the lungs, but little is known about inducing matrix clearance and fibrosis resolution in humans. This application seeks to address the pivotal role of MMP-9 activation for matrix degradation via plasminogen/plasmin cascade in fibroblasts. The results of our studies should provide insight into the development of novel therapeutic strategies to induce fibrosis resolution that will improve the outcomes for patients with fibrotic lung disease.

PI_NAMEs: REDENTE, ELIZABETH FRANCES (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Acceleration;Address;Animal Model;Attention;Automobile Driving;Bleomycin;Cicatrix;Clinical;Collagen;Data;Degradation Pathway;Deposition;Development;Disease;Enzyme Activators;Enzymes;Excision;Exhibits;Extracellular Matrix;Extracellular Matrix Degradation;Fibroblasts;fibrogenesis;Fibrosis;fibrotic interstitial lung disease;fibrotic lung;fibrotic lung disease;Formulation;Gelatinase B;Generations;genetic approach;Human;idiopathic pulmonary fibrosis;Impairment;improved outcome;In Vitro;in vivo;Inflammatory;Inhibition of Matrix Metalloproteinases Pathway;insight;Interstitial Lung Diseases;Life Expectancy;Lung;Matrix Metalloproteinase Inhibitor;Matrix Metalloproteinases;Mediating;Mediator;Modeling;Molecular;mortality;Mus;mutant;neglect;novel;novel therapeutic intervention;novel therapeutics;Outcome;overexpression;Pathologic;Pathway interactions;Patient-Focused Outcomes;Patients;pharmacologic;Phenotype;Plasmin;Plasminogen;Plasminogen Activator;Plasminogen Activator Inhibitor 1;pre-clinical;prevent;Process;Production;ProMMP-9;Proteins;Pulmonary Fibrosis;Recombinants;repaired;Resolution;response;Role;Series;Signal Transduction;targeted treatment;Testing;Therapeutic Intervention;Therapeutic Studies;Therapeutically Targetable;Time;Tissues;TNF gene;Transcript;Urokinase;Wild Type Mouse;Work;wound healing

PROJECT_TITLE: Activation of matrix metalloproteinase-9 is essential to overcome failed fibrosis resolution

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative Advancing the science of sustainability is important and urgent, as inequities in cancer and challenges to the sustainability of evidence-based programs persist and were exacerbated during the COVID-19 pandemic. This research seeks to help address gaps in understanding how to actively enhance the sustainability of evidence-based programs, particularly in lower- resource community settings. Specifically, the proposed study will help inform understanding of what strategies are effective in promoting the long-term delivery and impact of a program focused on improving racial inequities in cancer screening among Black women.

PI_NAMEs: SHELTON, RACHEL C (contact)

PROGRAM_OFFICER_NAME: SARMA, ELIZABETH ANNE

PROJECT_TERMS: Accountability;Address;Area;Behavior;Black race;black women;Breast;Businesses;Cancer Burden;Cancer Center;Cancer Control;Cancer Model;cancer prevention;Cancer Survivor;Cervical Cancer Screening;Collaborations;Communities;Community of Practice;community partnership;community setting;COVID-19 pandemic;design;Diagnostic;Discrimination;Early Diagnosis;Education;Educational Curriculum;Entrepreneurship;Equity;Evaluation;evidence base;Evidence based program;experience;Face;follow-up;Goals;Health;health equity;health inequalities;Healthcare;implementation science;improved;Inequity;Infrastructure;Institution;Institutionalization;Interview;Knowledge;Lead;Longevity;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Medical;Methods;Modeling;National Cancer Institute;novel;Outcome;Participant;Play;Process;programs;prospective;Prospective Studies;racial disparity;Racial Equity;Research;Resource-limited setting;Resources;scale up;Science;Scientific Advances and Accomplishments;Screening for cancer;screening program;Services;Site;skills;social;Surveys;sustainability framework;systemic barrier;Testing;theories;Time;Training;Trust;Underserved Population;uptake;Woman;Work

PROJECT_TITLE: Strategies for Reaching and Impacting Our Communities Sustainably (NWP-ROCS Program)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-D (02)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine;Prostate Cancer;Urologic Diseases

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE Resistance to current AR-targeted therapies poses a significant hurdle in treating advanced prostate cancer (PCa), severely affecting clinical outcomes for patients battling this lethal disease. Our research has identified a prevalent ZNF397 deficiency, observed in 25-40% of PCa patients, which propels the transition of cancer cells from an AR-driven luminal lineage to a TET2-driven lineage plastic state, thereby fostering AR-targeted therapy resistance. This study aims to unravel the molecular mechanism behind ZNF397-deficiency-induced lineage plasticity and AR-targeted therapy resistance, with a goal to develop innovative therapeutic approaches to overcome resistance and benefit patients suffering from this devastating disease.

PI_NAMEs: MU, PING  (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: advanced prostate cancer;Affect;androgen independent prostate cancer;Androgen Receptor;Biological Markers;cancer cell;cancer initiation;Cancer Patient;Cells;Clinical;Clinical Trials;clinically relevant;combat;Complication;Disease;Effectiveness;efficacy evaluation;enzalutamide;Epigenetic Process;Event;experience;Fostering;Genetic;Genetic Transcription;Genetically Engineered Mouse;Goals;improved;inhibitor;innovation;Laboratories;Malignant neoplasm of prostate;Malignant Neoplasms;Modeling;Modernization;Modification;Molecular;novel;novel strategies;novel therapeutic intervention;Outcome;Patient-Focused Outcomes;Patients;Pharmacologic Substance;Phenotype;predictive marker;programs;prostate cancer cell;receptor expression;Research;Resistance;resistance mechanism;Resolution;Role;single-cell RNA sequencing;System;targeted treatment;Testing;Therapeutic;therapeutic target;transcriptomics;treatment response;tumor;tumor heterogeneity;Tumor Suppressor Proteins;tumorigenesis

PROJECT_TITLE: Deciphering the Impact of ZNF397-deficiency in Promoting TET2-driven Epigenetic Rewiring, Lineage Plasticity, and Therapy Resistance in Prostate Cancer

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Rare Diseases

ORG_CITY: COLUMBIA

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative: Abdominal aortic aneurysm (AAA) is a potentially lethal disease that lacks pharmacological treatment, and aortic wall medial smooth muscle degeneration and adventitia remodeling are the determining factors for AAA progression and aortic rupture. In this application, a combination of molecular, cellular, and genetic approaches with gain-of- and loss-of-function studies will be used to establish novel mechanisms by which Smad2 hinders AAA progression by inhibiting vascular smooth muscle necroptosis while facilitating adventitia protective responses. The outcome of the project may lead to the development of new strategies for the prevention or therapy of AAA.

PI_NAMEs: CHEN, SHIYOU  (contact)

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TERMS: Abdominal Aortic Aneurysm;Angiotensin II;animal facility;Aorta;Aortic Diseases;Aortic Rupture;Apolipoprotein E;Apoptosis;Arteries;Attenuated;autosome;Basic Science;Blood Vessels;cell dedifferentiation;Cell Proliferation;Cell Survival;cell type;Cells;Cellular biology;Cessation of life;Cleavage Under Targets and Release Using Nuclease;clinical application;Collagen;Core Facility;Data;Death Rate;Deposition;Development;Disease;Dissection;Down-Regulation;Elastases;Elastin;Environment;Equipment;Event;Female;Fibroblasts;Future;Genes;genetic approach;Genetic Recombination;Histologic;Homeostasis;Human;Impairment;In Vitro;in vivo;Infusion procedures;Knockout Mice;Knowledge;Laboratories;Lead;Lesion;loss of function;male;Medial;Missouri;Modeling;Molecular;Mus;muscle degeneration;Neural Crest Cell;novel;novel strategies;novel therapeutic intervention;nuclease;Outcome;Pathologic;Pathology;Pathway interactions;Pericytes;Pharmacological Treatment;Phenotype;Phosphorylation;Phosphotransferases;Play;Positioning Attribute;preservation;prevent;Prevention strategy;Proliferating;Protein Kinase Interaction;Proteins;Publications;Publishing;Receptor-Interacting Protein;Regulation;Research;Resources;response;RIPK3 gene;Role;Rupture;Ruptured Abdominal Aortic Aneurysm;Signal Transduction;single-cell RNA sequencing;Smooth Muscle;Smooth Muscle Myocytes;Techniques;Technology;Testing;therapeutically effective;TNF gene;transdifferentiation;Transforming Growth Factor beta;Tunica Adventitia;Universities;Up-Regulation;vascular inflammation;Vascular Smooth Muscle;Wild Type Mouse

PROJECT_TITLE: Novel Mechanisms underlying abdominal aortic aneurysm progression

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: PROJECT NARRATIVE Mechanisms driving spontaneous preterm birth remain incompletely understood, although premature cervical remodeling appears to be a common pathway leading to preterm birth. The proposed research aims to identify mechanisms through which polyamines, which are relatively abundant metabolites in the cervicovaginal space, affect cervical remodeling and risk of preterm birth. Of significant translational and public health importance, this work will provide the basis for potential development of polyamine-based preventative or therapeutic interventions to mitigate risk of spontaneous preterm birth, the leading cause of neonatal morbidity and mortality worldwide.

PI_NAMEs: GERSON, KRISTIN DUCREST (contact)

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: 16S ribosomal RNA sequencing;Affect;Amino Acids;anti-microbial peptide;antioxidant enzyme;Antioxidants;Arginine;Automobile Driving;Biological;Biological Process;Biological Response Modifiers;Cell Communication;Cervical;cervical remodeling;cervicovaginal;Cervix Uteri;Coculture Techniques;cohort;Communities;Complex;cytokine;Decarboxylation;Development;Diamines;DNA;Ecosystem;Enzyme-Linked Immunosorbent Assay;Epithelial Cells;Epithelium;Equilibrium;Experimental Designs;Flow Cytometry;Functional disorder;Goals;Homeostasis;Human;Immune;Immune response;Immunity;immunoregulation;improved;improved outcome;In Vitro;in vitro Model;Individual;Inflammasome;Inflammation;innovation;Knowledge;Lactobacillus;Length;lens;Link;Lipid Peroxidation;lipidomics;Lipids;Macrophage;Matrix Metalloproteinases;Measures;Mediating;metabolome;metabolomics;Methodology;Microbe;microbial;microbial community;microbiota;Modification;neonatal morbidity;Neonatal Mortality;novel;Ornithine;Outcome;Oxidative Stress;Pathway interactions;peroxidation;Phenotype;Physiological;Play;Polyamines;Pregnancy;Pregnancy Outcome;premature;Premature Birth;preventive intervention;Process;Production;Propylamines;prospective;Proteins;Proteomics;Proxy;Public Health;Putrescine;Reproductive Health;reproductive outcome;Research;response;Risk;Risk Factors;risk mitigation;Role;screening;Signal Transduction;Spermidine;Spermine;Swab;System;Testing;Therapeutic;Therapeutic Intervention;Tissues;Vagina;Work

PROJECT_TITLE: Polyamine modification of host immune responses and oxidative balance in the cervicovaginal space: potential mechanisms governing cervical remodeling in preterm birth

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Social Determinants of Health

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE Vocal communication is hugely important to our social lives, but the brain circuits that allow humans and other animals to vocalize appropriately according to behavioral context remain poorly understood. The goal of this proposal is to characterize the brain circuits that underlie the flexible, context-dependent control of vocalization, which will inform our understanding of brain mechanisms that underlie differences in vocal communication in neurodevelopmental disorders.

PI_NAMEs: TSCHIDA, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Ablation;Acoustics;Affect;Animals;autism spectrum disorder;Axon;Behavioral;Brain;Categories;Communication;Communication impairment;Courtship;experimental study;Female;flexibility;Foundations;Goals;hindbrain;Human;Hypothalamic structure;Impairment;in vivo calcium imaging;Individual;Label;Light;Link;male;Mammals;Maps;midbrain central gray substance;Midbrain structure;Mission;model of autism spectrum disorder;Motivation;Motor Neurons;mouse model;Mus;National Institute on Deafness and Other Communication Disorders;neural circuit;Neurodevelopmental Disorder;neuronal circuitry;Neurons;novel;optical imaging;Optics;Population;Production;Prosencephalon;Sex Differences;social;Social Behavior;social cohesion;Social Controls;Social Environment;Social Interaction;social relationships;Societies;System;Testing;tool;Ultrasonics;vocal control;vocalization;Work

PROJECT_TITLE: Neural Circuits for Context-Dependent Control of Vocal Communication

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Orphan Drug;Ovarian Cancer;Rare Diseases;Telehealth;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE In the era of precision oncology, more patients are living longer with advanced cancer, yet many of the new treatments cause unrelenting fatigue which interferes with daily life and may lead to non-adherence or discontinuation of these breakthrough therapies. Despite this, there are few effective, evidence-based treatments for fatigue in metastatic cancer. This study rigorously evaluates REVITALIZE--a well-piloted telehealth intervention designed to improve fatigue outcomes in patients with advanced ovarian cancer taking PARP inhibitors--in a fully-powered randomized trial in patients treated at both academic and community cancer clinics that serve diverse communities.

PI_NAMEs: ARCH, JOANNA J;WRIGHT, ALEXI A (contact)

PROGRAM_OFFICER_NAME: SAMIMI, GOLI

PROJECT_TERMS: Address;Adherence;Adult;advanced disease;Advanced Malignant Neoplasm;Behavior;Breast;cancer diagnosis;Cancer Patient;cancer recurrence;cancer risk;Cancer Survivor;cancer therapy;cancer type;Caring;Cessation of life;Clinic;Clinical;Cognitive Therapy;Communities;Data;Diagnosis;Disease;Disseminated Malignant Neoplasm;Dose;effective therapy;Evidence based treatment;Fatigue;follow-up;Foundations;Home;improved;improved outcome;Individual;Interruption;Intervention;Life;Malignant neoplasm of ovary;Malignant Neoplasms;Mediator;Meta-Analysis;Monitor;monitoring device;Nausea;novel anticancer drug;novel therapeutics;Oral;Outcome;Outcome Assessment;Pancreas;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pharmacologic;pilot test;Placebos;Poly(ADP-ribose) Polymerase Inhibitor;Population;post intervention;precision oncology;primary outcome;Prostate;Quality of life;randomized trial;Randomized, Controlled Trials;Relative Risks;remote delivery;Reporting;Risk;Science;secondary outcome;Self Efficacy;Severities;side effect;Specific qualifier value;Supportive care;survivorship;telehealth;Testing;theories;therapy design;Translating;treatment as usual;Variant;Work

PROJECT_TITLE: Randomized trial of REVITALIZE: A telehealth intervention to reduce fatigue interference among adults with advanced ovarian cancer on PARP inhibitors

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: PITTSBURGH

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative The proposed research is relevant to public health because it will unravel the mechanisms by which a recently identified gene mutation results in severe and debilitating neurodevelopmental consequences, including intellectual disability, epilepsy and autism. Thus, the proposed research is relevant to the NIH's mission of supporting fundamental research that will ultimately cure disease.

PI_NAMEs: THOMAS, GARY  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Acute;aerobic glycolysis;Antisense Oligonucleotides;autism spectrum disorder;base;Behavior;Behavior assessment;behavior test;Behavioral;behavioral study;Binding;Brain;Buffers;Calcium;Calcium Signaling;Cell Physiology;Cell Respiration;Cells;Cellular biology;Client;Communication;Complex;Coupling;curative treatments;Cytoplasm;Cytosol;Data;Defect;Development;Diffusion;Disease;effective therapy;Electroencephalography;Electrophysiology (science);Epilepsy;epileptic encephalopathies;Frequencies;fundamental research;Gene Expression;Gene Mutation;Genus Hippocampus;global developmental delay;Glucose;Glutamates;Goals;hippocampal pyramidal neuron;Impairment;inhibitor therapy;innovation;Intellectual functioning disability;Intervention;Learning;lipid metabolism;live cell imaging;Measures;Mediating;Membrane Protein Traffic;Metabolic;Metabolism;metabolomics;Missense Mutation;Mission;Mitochondria;mitochondrial metabolism;Modeling;Molecular;mouse model;Mus;Muscle hypotonia;Mutation;NADH;neonatal seizure;Neurodevelopmental Disorder;Neuronal Dysfunction;neuronal metabolism;Neurons;neurotransmission;Nuclear;Pathway interactions;Patients;Permeability;pharmacologic;Phosphorylation;PKD2 protein;postsynaptic;Protein Sortings;Proteins;Public Health;Recurrence;Research;Rest;Signaling Molecule;SIRT1 gene;Slice;Source;Structure;Synapses;Synaptic Transmission;Syndrome;Testing;Therapeutic;therapeutic RNA;tool;transcriptome sequencing;Transfection;translational framework;two photon microscopy;United States National Institutes of Health

PROJECT_TITLE: Impact of the E209K PACS2 Syndrome mutation on neuronal metabolism and neurotransmission.

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Microbial infections are one of the leading causes of cancer worldwide. We will use functional proteomic methods to determine how infection-induced oxidative stress, which is a driving force in cancer development, promotes cancer signaling at the protein level. Our findings will increase understanding of infection-induced signaling pathways that contribute to cancer development and may lead to new strategies for inhibiting these pathways during infection.

PI_NAMEs: HATZIOS, STAVROULA  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Acceleration;Address;Affect;Animal Model;asparaginylendopeptidase;Bacterial Proteins;Biochemical;Biogenesis;Cancer Etiology;Cell Physiology;Cell Proliferation;Cells;cellular targeting;Chemicals;Chemistry;chemoproteomics;Chronic;chronic infection;Code;Cysteine;Data;Development;Disease;DNA;DNA sequencing;driving force;Epidermal Growth Factor Receptor;Event;extracellular;Gastric Glands;Gene Expression Profiling;Genetic;genetic approach;Goals;Helicobacter Infections;Helicobacter pylori;host-microbe interactions;Human;Immune response;in vivo;Infection;Inflammation;insight;intermolecular interaction;Label;Link;Malignant Neoplasms;Maps;Metabolic;Metabolism;metaplastic cell transformation;Methods;Microbe;microbial;Modification;Molecular;Mus;Mutate;Mutation;novel;Nucleosides;Oncoproteins;oxidation;Oxidation-Reduction;Oxidative Stress;Oxidative Stress Induction;pathogen;Pathogenesis;Pathway interactions;Peptide Hydrolases;Phenotype;polysome profiling;prevent;Process;programs;Proliferating;protein function;Proteins;Proteome;Proteomics;Research;Ribosomal Proteins;Ribosomes;Shapes;Signal Induction;Signal Pathway;Signal Transduction;Site;Stomach;Sulfhydryl Compounds;Testing;Time;Tissues;trafficking;Translational Repression;Translations;tumor;tumor growth;tumorigenesis;tumorigenic;Work;Xenograft Model

PROJECT_TITLE: Chemoproteomic discovery and functional characterization of infection-induced oxidation sites

STUDY_SECTION: CBP

STUDY_SECTION_NAME: Chemical Biology and Probes Study Section[CBP]


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Services;Immunization;Infectious Diseases;Influenza;Lung;Pediatric;Pneumonia and Influenza;Prevention;Primary Health Care;Vaccine Related

ORG_DEPT: PEDIATRICS

PHR: Project Narrative We propose a pragmatic Hybrid Type 2 effectiveness/implementation trial with national scope vital to understanding the effectiveness and implementation of behaviorally-informed COVID-19 and influenza text message reminders across parents with varied backgrounds and whose children are cared for in diverse practice settings. On a national scale, understanding the effectiveness and implementation of influenza and COVID-19 vaccine text message reminders among a diverse pediatric population will provide key information to clinicians, health systems, health departments and policymakers to bolster vaccine receipt and counter vaccine hesitancy.

PI_NAMEs: FIKS, ALEXANDER GABRIEL;STOCKWELL, MELISSA S (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 17 year old;2019-nCoV;Academy;Adolescent;Adoption;age group;American;arm;Behavioral;Caregivers;Cause of Death;Characteristics;Child;Child Care;Childhood;Combined Vaccines;compare effectiveness;Consolidated Framework for Implementation Research;contextual factors;cost;COVID-19;COVID-19 vaccination;COVID-19 vaccine;Disease;Dose;Drops;Effectiveness;effectiveness/implementation trial;Family;global health;Health;Health system;Hybrids;implementation barriers;implementation strategy;Individual;Influenza;influenza infection;Influenza vaccination;influenza virus vaccine;Language;Maintenance;Methods;Morbidity - disease rate;mortality;multi-site trial;Parents;Pediatric Research;Pediatrics;Pneumonia;Policy Maker;Population;practice setting;practice-based research network;Primary Care;primary care practice;primary outcome;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Recording of previous events;recruit;Research;Schedule;Seasons;Shapes;Site;success;Testing;Text Messaging;Time;treatment as usual;Uncertainty;Vaccination;vaccine effectiveness;vaccine hesitancy;vaccine safety;Vaccines

PROJECT_TITLE: Text4Vax: Understanding the Effectiveness and Implementation of Text Message Reminders for Pediatric COVID-19 and Influenza Vaccines

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-P (91)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Neurosciences

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE Age-related memory decline is one of the most salient cognitive deficits affecting older adults. Negative impacts of memory failures in older adults can range from emotional distress and embarrassment to potential life- threatening outcomes, especially in cases where individuals experience memory errors for important health and safety information. Identifying strategies to reduce these errors is critical to enhancing memory functioning and quality of life in healthy older adults.

PI_NAMEs: DENNIS, NANCY ANNE (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Affect;age difference;age related;Aging;aging population;Behavioral;Binding;Cognitive;Cognitive aging;Cognitive deficits;cognitive process;Dementia;Dissociation;dosage;emotional distress;evidence base;Exhibits;experience;Face;Failure;flexibility;Functional Magnetic Resonance Imaging;Goals;Grouping;Growth;Health;Hippocampus;human old age (65+);improved;Individual;information processing;Information Theory;innovation;Knowledge;Life;life span;Link;long term memory;Medicine;Meditation;member;Memory;Memory impairment;Memory Loss;memory process;Methods;Multivariate Analysis;Names;neural;neural patterning;neurocognitive test;neurodevelopment;neuroimaging;neuromechanism;normal aging;older adult;Outcome;Parietal;Participant;Perception;Performance;Play;Population;Process;Quality of life;Research;Resolution;Retrieval;Role;Safety;scaffold;semantic processing;Semantics;Short-Term Memory;success;Testing;theories;Work;young adult

PROJECT_TITLE: The use of high-resolution fMRI to elucidate the cognitive and neural mechanisms underlying the benefits of environmental support on associative memory in younger and older adults

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ORG_CITY: HONOLULU

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: Project Narrative ZFY is an essential and conserved Y chromosome encoded male fertility factor but how it imposes its important role has not been established. Using new mouse models that we developed, we will investigate the molecular function of mouse Zfy. Our findings will impact on understanding on genetic regulation of spermatogenesis and origin of male infertility, with consequences for advancing knowledge about these processes in humans.

PI_NAMEs: WARD, MONIKA A (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Address;Attention;Binding Proteins;Biochemical;Biological Assay;cell type;Chromatin;chromatin immunoprecipitation;chromosome mutation;CRISPR/Cas technology;Data;Defect;Epitopes;Evolution;F Factor;forgetting;Gene Modified;Gene Proteins;Genes;Genetic;Germ Cells;Goals;Homologous Gene;Human;human male;Immunohistochemistry;Immunoprecipitation;In Vitro;in vivo;Infertility;insight;Investigation;Knock-in;Knock-in Mouse;Knock-out;Knockout Mice;Knowledge;male;male fertility;Male Infertility;Mass Spectrum Analysis;Meiosis;Methods;Mission;Molecular;Morphology;mouse model;Mus;National Institute of Child Health and Human Development;National Institute of General Medical Sciences;Nuclear;Oocytes;Open Reading Frames;Pathway interactions;Phenotype;Play;postnatal;Preparation;Process;Production;protein expression;Proteins;Proteome;Publishing;Regulation;Reporter;Reporting;Reproduction;Role;Sex Chromosomes;sperm cell;Spermatids;Spermatocytes;Spermatogenesis;Spermatogenic Cell;Testing;Testis;testis determining factor;Transcript;transcription factor;transcriptome;transcriptome sequencing;Transgenes;Transgenic Organisms;Up-Regulation;Western Blotting;Work;Y Chromosome;ZFY protein;Zinc Fingers

PROJECT_TITLE: The roles of mouse Y chromosome Zfy genes in male reproduction.

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Rare Diseases

ORG_CITY: DALLAS

ORG_DEPT: PATHOLOGY

ORG_STATE: TX

PHR: PROJECT NARRATIVE Chromothripsis describes a process in which chromosomes catastrophically shatter into fragments and reassemble to form rearranged chromosomes that can fuel cancer development. How these chromosomes undergo fragmentation remains a critical knowledge gap in our understanding of the etiology of chromothripsis. This proposal seeks to test the hypothesis that chromothripsis is caused by DNA replication defects that persist into mitosis, which subsequently activates a pathological DNA repair program that triggers extensive chromosome breakage.

PI_NAMEs: LY, PETER  (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Address;Automobile Driving;Biogenesis;cancer cell;cancer genome;Cancer Patient;cancer predisposition;Cell Cycle;Cell Cycle Stage;Cell division;Cell Extracts;Cell Nucleus;Chromosome Breakage;chromosome missegregation;chromosome replication;Chromosomes;chromothripsis;Complex;CRISPR screen;Defect;Development;DNA;DNA biosynthesis;DNA Damage;DNA lesion;DNA Repair;DNA Repair Pathway;DNA replication fork;DNA Sequence Alteration;DNA Sequence Rearrangement;Drug resistance;Elements;Etiology;Evolution;Experimental Models;extrachromosomal DNA;FANCD2 protein;Fanconi Anemia pathway;Fanconi's Anemia;Fiber;G2 Phase;Gene Fusion;Genes;Genome;Genomic Instability;genomic locus;Genomics;Human;In Vitro;Individual;insight;Interphase;Kinetics;Knowledge;Ligation;live cell imaging;Malignant Neoplasms;Mediating;micronucleus;Mitosis;Mitotic;Mitotic Chromosome;Modeling;Molecular;Monitor;Monoubiquitination;Mutation;Nuclear;Nuclear Structure;nuclease;Oncogenic;Pathologic;Patients;Predisposition;Process;programs;Property;recruit;resistance gene;Resolution;response;Role;Rupture;single molecule;Source;Speed;Structure;Testing;tumor;Tumor Suppressor Genes;whole genome

PROJECT_TITLE: Mechanisms of Chromosome Shattering from Defective DNA Replication

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE The cause of inguinal hernia is not well understood, though it is highly prevalent, occurring in 1 out of 4 elderly men. Hernia repair surgery is the only option for treating inguinal hernia; however, refractory hernias accompanied by long-term severe postoperative pain, infection, and high recurrence continue to challenge surgeons. We will investigate a novel mechanism underlying inguinal hernia formation that links progesterone hormone signaling with abdominal muscle fibrosis in a unique and clinically relevant mouse model and in human tissues, and propose to test the effect of treatments that block progesterone action to prevent or reverse hernias.

PI_NAMEs: BULUN, SERDAR E. (contact);ZHAO, HONG

PROGRAM_OFFICER_NAME: ANDERSEN, DANA K

PROJECT_TERMS: Abdominal Muscles;Ablation;Acetates;Adjuvant Therapy;Affect;Aging;Anatomy;antagonist;Area;Aromatase;Aromatase Inhibitors;ATAC-seq;Atrophic;Bioinformatics;Biopsy;Blood;Cell Nucleus;Characteristics;ChIP-seq;clinically relevant;conditional knockout;Data;Development;Disease;Elderly man;Enzymes;epigenomics;Estradiol;Estrogen Antagonists;Estrogen Receptors;Extracellular Matrix;Fibroblasts;Fibrosis;Gene Expression;Genes;Genetic;genetic signature;Genomics;Hernia;Hernia of abdominal cavity;high risk population;Histologic;hormonal signals;Human;human disease;human tissue;Immunohistochemistry;in vivo;Incidence;Infection;Inguinal Hernia;Intervention;knock-down;Knock-out;Label;Lead;Link;male;Measures;Mediating;Mediator;men;Messenger RNA;Mifepristone;Modeling;Molecular;morphometry;mouse model;multiple omics;Mus;Muscle;Muscle Cells;Muscle Weakness;Muscular Atrophy;new therapeutic target;novel;Operative Surgical Procedures;Osteoporosis;Pathway interactions;Phenotype;Platelet-Derived Growth Factor alpha Receptor;Postoperative Pain;prevent;Preventive;Process;Progesterone;Progesterone Receptors;Progestins;Proliferating;Proteins;receptor;receptor expression;Receptor Signaling;Recurrence;Refractory;repaired;Role;RU-5020;Sexual Dysfunction;side effect;single-cell RNA sequencing;Skeletal Muscle;Small Interfering RNA;Surgeon;Testing;Testosterone;Therapeutic;therapeutic development;Tissues;transcriptome sequencing;treatment effect;Western Blotting;Wild Type Mouse;XCL1 gene

PROJECT_TITLE: Skeletal Muscle Fibrosis and Progesterone Receptor

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE Glaucoma, a leading cause of blindness in the United States, is characterized by injury to the axons of the retinal ganglion cells and extensive changes in the structure of the tissues of the optic nerve head that may affect their mechanical properties and deformation response to the intraocular pressure. This project seeks to understand: 1) whether the deformation and mechanical properties of the optic nerve head, measured by current state-of-the-art imaging, image analysis and modeling methods, can predict the risk of progression of optic nerve damage in open angle glaucoma, and 2) how the structure and material properties of the optic nerve head tissues change during glaucoma progression. The findings of the proposed project may lead to the development of new biomechanical markers for the reduction in susceptibility to glaucoma damage in human eyes, which would predict the outcome of glaucoma surgery to lower the intraocular pressure, provide more efficient outcome measures for initial human scleral neuroprotection trials, and for the development of new therapies that alter the mechanical behavior of the optic nerve head tissues to mitigate glaucoma damage.

PI_NAMEs: NGUYEN, THAO D (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Accounting;Acute;Affect;Aftercare;Age;Anatomy;Astrocytes;Axon;axon injury;Behavior;Biological Markers;Biomechanics;Blindness;Blood flow;Blood Vessels;Cells;Cerebrospinal Fluid;Cessation of life;Clinical;Clinical Trials;Computer Models;Connective Tissue;Consensus;Cytolysis;Data;Development;digital;Disease;Effectiveness;Elements;Eye;Eyedrops;FDA approved;field study;follow-up;Geometry;Glaucoma;glaucoma surgery;Home;Human;human subject;Image;Image Analysis;imaging modality;Injury;Intervention;Intracranial Pressure;Lasers;Long-Term Effects;Longitudinal Studies;longitudinal, prospective study;Measurable;Measures;mechanical behavior;mechanical properties;Mechanics;Methods;Modeling;nerve damage;Nerve Tissue;neural;neuroprotection;Normal Pressure Hydrocephalus;novel therapeutics;Open-Angle Glaucoma;Operative Surgical Procedures;Optic Disk;Optic Nerve;Optical Coherence Tomography;optical imaging;Outcome;Outcome Measure;outcome prediction;Patient Care;Patient Participation;Patients;Periodicals;Persons;Pharmaceutical Preparations;Physiologic Intraocular Pressure;Physiological;Positioning Attribute;post intervention;Postoperative Care;Predisposition;pressure;Primary Open Angle Glaucoma;progression risk;Property;prospective;Publishing;Race;Reaction;response;retinal axon;retinal damage;Retinal Ganglion Cells;retinal nerve fiber layer;risk prediction;Safety;Sample Size;Sampling;Sclera;sex;Site;Structure;Subjects Selections;Surgical sutures;Testing;Therapeutic;Thick;Time;Tissues;Trabeculectomy;United States;Variant;viscoelasticity;Visual Fields;Withdrawal

PROJECT_TITLE: Biomechanics of the Human Optic Nerve Head for Glaucoma Biomarkers.

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Atherosclerosis;Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Endocrine Disruptors;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CORAL GABLES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative Per- and polyfluoroalkyl substances (PFAS) represent a growing public health concern due to their ubiquitous exposure, resistance to environmental degradation, bioaccumulation, neurotoxicity, and effects on cardiometabolic risk factors. Identifying mechanisms through which PFAS exposures impact dementia risk represents an opportunity to prevent dementia at the individual and community level.

PI_NAMEs: GARDENER, HANNAH  (contact)

PROGRAM_OFFICER_NAME: KWOK, RICHARD K

PROJECT_TERMS: Acceleration;adjudication;Adult;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Apolipoprotein A-I;apolipoprotein E-4;Apolipoproteins B;Archives;Area;Atherosclerosis;Attention;Behavioral;bioaccumulation;Biological;Biological Markers;Black Populations;Black race;Blood;Blood Vessels;cardiometabolic risk;Caribbean Hispanic;Carotid Artery Plaques;Carotid Atherosclerotic Disease;Cerebrum;Child;Clinical;Clothing;Cognitive;cognitive performance;cohort;Communities;Consumption;Cross-Sectional Studies;Data;Dementia;dementia risk;design;Diabetes Mellitus;Diet;dietary;Disease;Environmental Health;ethnic disparity;Ethnic Population;Event;experience;Fishes;follow-up;Food;Food Packaging;Food Supply;Foundations;Furniture;Genetic;Genotype;Goals;Health;Health behavior;Health Policy;Health Priorities;High Density Lipoproteins;high risk;Hispanic;Hispanic Populations;Home;Human;Hyperlipidemia;Hypertension;imaging biomarker;Immunologic Markers;Impaired cognition;Individual;Inflammation;innovation;insight;intimal medial thickening;Investigation;kidney dysfunction;Knowledge;Link;lipid metabolism;Lipids;Lipoprotein (a);Literature;Longitudinal cohort;Longitudinal Studies;Mediating;Mediation;Mediator;Medical History;Methodology;mild cognitive impairment;Modification;multi-ethnic;National Health and Nutrition Examination Survey;neurodevelopment;Neuroepidemiology;neuroimaging;Neuropsychology;neurotoxicity;Obesity;Outcome;Participant;Pathway interactions;persistent organic pollutants;Pharmaceutical Preparations;Phenotype;Poly-fluoroalkyl substances;Population;population based;Population Heterogeneity;Positioning Attribute;prevent;Prevention;preventive intervention;prospective;Prospective, cohort study;Public Health;racial disparity;Recommendation;remediation;Renal function;Research;Research Priority;Resistance;Risk;Risk Factors;Role;Sampling;secondary outcome;Serum;sex disparity;sociodemographics;Stroke;study population;substance use;Time;Tissues;United States National Institutes of Health;vascular cognitive impairment and dementia;vascular risk factor;Water;Water Supply;Work

PROJECT_TITLE: The role of PFAS in lipid-mediated vascular contributions to cognitive impairment and dementia: PFAS VascCog Longitudinal Study

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]