NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Inflammatory Bowel Disease

PI_NAMEs: KUPFER, SONIA  (contact)

PROJECT_TERMS: Address;animal tissue;Archives;Basic Science;Behavior;Biological Specimen Banks;Biopsy;Biopsy Specimen;Cells;Cessation of life;Chicago;Clinical;Clinical Data;clinical database;Clinical Investigator;Complex;Consent;Consultations;Data;Digestive System Disorders;DNA;Ensure;epidemiologic data;Epidemiology;Experimental Designs;Fee-for-Service Plans;Formalin;Foundations;Freezing;Functional disorder;Future;gastrointestinal;Gastrointestinal Diseases;Generations;Goals;Histopathology;Human;human study;human tissue;Immunohistochemistry;Implant;improved;Individual;Inflammatory Bowel Diseases;Infrastructure;Institutional Review Boards;Instruction;Interdisciplinary Study;Intestines;liver biopsy;member;Metadata;neoplasm registry;Paraffin Embedding;Pathogenesis;Pathologist;Pathology;Patient Recruitments;Patients;Phenotype;phenotypic data;Physiology;Population;Procedures;prospective;recruit;Registries;Research;Research Design;Research Personnel;Resources;RNA;sample collection;Sampling;screening;Serum;service utilization;Services;Source;Specimen;Stains;Statistical Data Interpretation;Techniques;therapeutic development;Tissue Banks;Tissue Embedding;Tissues;Translational Research;translational scientist;translational study;Universities;virtual;Whole Blood;Work

PROJECT_TITLE: Integrative Clinical and Biospecimen (IBC)


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Prevention;Suicide;Suicide Prevention

ORG_CITY: SALT LAKE CITY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Autistic individuals are at high risk for increased suicidality and suicide mortality, and require suicide prevention research tailored to their unique needs. This research involves examining suicide risk and protective factors, as well as developing and piloting a novel community-based suicide prevention intervention for autistic individuals. The use of community-based participatory research methods will promote the ultimate goal of reduced suicidality and enhanced quality of life in the autistic community.

PI_NAMEs: KIRBY, ANNE V (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: acceptability and feasibility;Address;Adult;adult with autism spectrum disorder;Advisory Committees;Advocate;Affect;Area;Attitude;autism community;autism spectrum disorder;autistic;career development;Clinical;clinical trial implementation;Clinical Trials;Communication difficulty;Communities;community based participatory research;community building;community intervention;Community of Practice;community partners;Complex;Data;Development;Education;empowerment;Ensure;evidence base;experience;Family;Family member;Feedback;Feeling suicidal;Genetic Load;Goals;Health Professional;high risk;Hybrids;implementation facilitators;implementation measures;individuals with autism spectrum disorder;innovation;Intervention;Intervention Community Trial;intervention refinement;Interview;Knowledge;Leadership;Learning;Licensing;Life;Measures;member;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Modeling;mortality;novel;Occupational Therapist;Outcome;Participant;pilot test;Population;population health;Populations at Risk;Preparation;Prevention;Prevention approach;Prevention Research;Prevention strategy;preventive intervention;Process;protective factors;Quality of life;Randomized;reducing suicide;Research;Research Methodology;Research Personnel;research study;Risk;Risk Factors;Senior Scientist;skills;social communication;social influence;sound;Structure;success;Suggestion;suicidal;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;suicide model;suicide mortality;Suicide prevention;Testing;Training;Translational Research;Waiting Lists;Work

PROJECT_TITLE: Participatory Research for Suicide Prevention in Autism

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Obesity;Clinical Research;Eating Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Mental Health;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Households with children are disproportionately affected by food insecurity, and in food-insecure households, adolescents are more vulnerable to experiencing disrupted eating patterns than younger children. Food-insecure adolescents face elevated risk for obesity in the United States, which is a significant public health concern due to its wide-ranging physical and mental health consequences, yet the reasons underlying this increased risk are not clear. By examining binge eating as a novel mechanism to explain the increased risk for adolescent obesity associated with food insecurity and evaluating potential approaches for promote food security and healthy weight among adolescents affected by food insecurity, findings from the proposed project will inform interventions to mitigate obesity risk in youth from under-resourced backgrounds. 1

PI_NAMEs: HAZZARD, VIVIENNE M (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Accounting;Adolescence;Adolescent;Adolescent obesity;Adult;Affect;Area;Award;Behavior;Beverages;Binge Eating;Body mass index;career;Child;cohort;Data;Decision Trees;Development;Dietary Factors;Dietitian;Eating;Energy consumption;Etiology;excessive weight gain;experience;Face;Feedback;Feeling;Food;food insecurity;food security;Funding;General Population;Goals;healthy weight;high body mass index;Household;human centered design;improved;innovation;Intervention;Interview;Knowledge;Longitudinal Studies;Machine Learning;marginalized population;Mediating;Mediation;Mediator;Mental Health;Mentors;Mentorship;Methods;Minnesota;Morbidity - disease rate;novel;Nutrient;Obesity;obesity prevention;obesity risk;Outcome;Pathway interactions;Pattern;Phase;physical conditioning;population based;Premature Mortality;Prevalence;prevent;Public Health;Qualitative Research;recruit;Reporting;Research;Research Personnel;Resources;response;Risk;Risk Factors;Role;Sampling;Schools;Statistical Methods;Statistical Models;Strategic Planning;Structure;Subgroup;Techniques;Testing;therapy design;therapy development;Time;Training;Trees;United States;United States National Institutes of Health;Universities;Weight;Weight Gain;Work;young adult;Youth

PROJECT_TITLE: Binge Eating as a Mechanism Underlying the Food Insecurity-Obesity Paradox in Adolescents

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Nutrition;Obesity

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the discovery of a phospholipid-dependent pathway that controls lipid and glucose homeostasis is expected to provide new insights into the pathogenesis of insulin resistance and its complications, including non-alcoholic fatty liver disease (NAFLD). The proposed studies are relevant to the mission of the NIDDK because they are expected to identify new therapeutic targets for the management of NAFLD.

PI_NAMEs: COHEN, DAVID E. (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Acyl Coenzyme A;Address;Binding;Binding Proteins;Biological Models;biophysical techniques;blood glucose regulation;Carbon;Cells;Characteristics;CoASH;Data;design;Disease;Elements;endoplasmic reticulum stress;Enzymes;Esterification;Esters;Event;experimental study;extracellular vesicles;Fasting;Fatty acid glycerol esters;fatty acid metabolism;fatty acid oxidation;Fatty Acids;Fatty Liver;feeding;Glean;Glucose;glucose metabolism;Glycerol;Goals;Grant;Head;Health;Hepatic;Hepatocyte;High Fat Diet;Homeostasis;In Vitro;Inflammation;insight;Insulin Resistance;insulin sensitivity;insulin signaling;Intake;Intervention;Intracellular Membranes;Lecithin;Length;Light;Link;lipid metabolism;Lipids;Liver;Mediating;Medication Management;member;Membrane;Membrane Fluidity;Metabolic;Metabolic Control;Metabolic Pathway;Metabolism;Mission;Mitochondria;Molecular;Molecular Conformation;mouse model;Mus;Muscle Fibers;muscle metabolism;Mutation Analysis;National Institute of Diabetes and Digestive and Kidney Diseases;new therapeutic target;non-alcoholic fatty liver disease;Nonesterified Fatty Acids;novel;Nutrient;nutrient metabolism;Nutritional;Obesity;Outcome Study;Overnutrition;Pathogenesis;Pathogenicity;Pathway interactions;pharmacologic;phosphatidylcholine transfer protein;Phospholipids;Phosphorylcholine;Physiological;protein function;Proteins;Public Health;Regulation;Research;Research Proposals;Resistance;response;Saturated Fatty Acids;sensor;Skeletal Muscle;skeletal muscle metabolism;small molecule;small molecule inhibitor;Specificity;Stress;Testing;Therapeutic;Tissues;Translating;Variant;vesicular release

PROJECT_TITLE: Phospholipid-Mediated Metabolic Control in the Pathogenesis of NAFLD

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Microbiome

ORG_CITY: STANFORD

ORG_DEPT: CHEMISTRY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Beneficial and pathogenic bacteria thrive in communities termed biofilms in which bacteria synthesize, secrete, and enmesh themselves with diverse biopolymers. Biofilms are linked to difficult-to-treat infections that can exhaust treatment options, yet there are no blueprints for how bacteria build these seemingly ordered architectures and uncovering these details can accelerate discovery of new anti-infectives. This research project introduces a multidisciplinary and broadly applicable approach to define fundamental assembly and organizational principles underlying the remarkable biofilm architectures formed by E. coli using functional amyloid fibers termed curli and newly discovered phosphoethanolamine cellulose.

PI_NAMEs: CHAMBERS, SCHUYLER A. (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Acceleration;Address;Adhesives;Ammonium;Amyloid;Amyloid fibers;Amyloid Proteins;Anti-Bacterial Agents;Anti-Infective Agents;Antibiotics;Architecture;Arginine;Bacteria;bacterial community;Bacterial Polysaccharides;Binding;Biochemical;Biological Assay;Biophysics;Biopolymers;cell community;Cell surface;Cells;Cellulose;Chemicals;clinically relevant;cohesion;commensal bacteria;Communities;Creativeness;design;Detection;Development;Diffusion;Disease;Disinfectants;efficacy evaluation;Escherichia coli;Evaluation;Event;exhaust;Exhibits;experimental study;extracellular;Extracellular Matrix;Extracellular Protein;Fellowship;Fluorescence Microscopy;Foundations;Future;Human Microbiome;immunoregulation;in vivo;Infection;Institution;Investigation;Isotope Labeling;Link;Magnetic Resonance;Mechanics;member;Mentorship;microbial;Microbial Biofilms;microbiome;Modification;Molecular;multidisciplinary;mutant;Nature;NMR Spectroscopy;novel;Nuclear Magnetic Resonance;Organism;pathogen;Pathogenesis;pathogenic bacteria;Pathology;phosphoethanolamine;Polymers;Polysaccharides;pressure;Production;recruit;Research;Research Project Grants;Role;Salmonella;Salmonella enterica;Sampling;solid state nuclear magnetic resonance;Structure;Symbiosis;Testing;Time;Tissues;Training;Universities;Urinary tract;Vancomycin;Visualization;Western Blotting;Work

PROJECT_TITLE: Probing the architecture, assembly, and function of amyloid-polysaccharide entanglements in bacterial biofilms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Clinical Research;Digestive Diseases;Inflammatory Bowel Disease;Regenerative Medicine

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PI_NAMEs: CHANG, EUGENE B (contact)

PROJECT_TERMS: Address;Antigen-Presenting Cells;Area;Attention;Biological Assay;Biological Models;Bone Marrow;Candidate Disease Gene;Cell Line;Cell model;cell preparation;Cell Separation;Cells;Chicago;Clinical;Coculture Techniques;Collaborations;comparative;cost;Cost Effective Management;Cost Savings;Cost Sharing;Data;Digestive System Disorders;Disease;Endoscopic Biopsy;Engineering;Ensure;Epithelial Cells;established cell line;Etiology;Experimental Models;Fostering;Functional disorder;Funding;gastrointestinal epithelium;gene transfer vector;Genomics;Genotype;Growth Factor;Health;host-microbe interactions;Human;Human Resources;Immune;Immunohistochemistry;Immunology;improved;in vivo;in vivo Model;Individual;Inflammation;Inflammatory Bowel Diseases;Interdisciplinary Study;interest;Intestines;Investigation;Knowledge;Measurement;member;mesenteric lymph node;Messenger RNA;Methods;Microbe;Microsurgery;Modeling;Molecular;Mucous Membrane;Mus;Mycoplasma Infections;Needs Assessment;novel;opportunity cost;Organoids;Patients;Peer Review;peripheral blood;Physiological;Physiology;Procedures;Publications;quality assurance;Recommendation;repository;Research;Research Personnel;Resources;Rodent;Sampling;Serum;Services;Spleen;System;T-Lymphocyte Subsets;Technical Expertise;Technology;Time;tissue culture;Tissue Engineering;Tissues;Training and Education;transcriptomics;Universities;Viral Vector

PROJECT_TITLE: Tissue Engineering and Cell Models (TECM)


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Gene Therapy;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: DAVIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative In accordance with the mission of the National Institute for Neurological Disorders and Stroke (NINDS) this grant will seek fundamental knowledge about the brain and nervous system and will use that knowledge to reduce the burden of neurological disease, specifically the feasibility of a novel delivery platform for epigenetic DNA-binding domains such as CRISPR/Cas9. This research holds great relevance for the advancement of treatment for those suffering from genetically-linked neurological disorders. The funds used for this research award will be used to develop a research pathway to critically evaluate an engineered stem cell delivery platform in a translationally relevant animal model to facilitate this approach towards clinical trials.

PI_NAMEs: FINK, KYLE  (contact);NOLTA, JAN A.

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Acceleration;Address;Adult;Alleles;animal data;Animal Model;anxiety reduction;Apoptosis;Area;Atrophic;Award;Binding;Biological Assay;Brain;Brain region;Brain-Derived Neurotrophic Factor;cell motility;Cell secretion;Cell Therapy;cell type;Cells;cellular engineering;Chromatin;cisterna magna;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Combined Modality Therapy;Corpus striatum structure;CRISPR therapeutics;CRISPR/Cas technology;Data;delivery vehicle;design and construction;Disease;disease phenotype;DNA Binding Domain;Dose;Double-Blind Method;effectiveness evaluation;efficacy study;engineered stem cells;Engineering;Epigenetic Process;Evaluation;excitotoxicity;Funding;Future;gene repression;Gene Silencing;Gene Targeting;gene therapy;Generations;Genes;Genetic Transcription;Glycoproteins;good laboratory practice;Grant;Growth Factor;Guide RNA;Half-Life;Heterochromatin;Human;Huntington Disease;Huntington gene;Immune;immunodeficiency;Impairment;implantation;Induced pluripotent stem cell derived neurons;Injections;Intraventricular;Investigational Drugs;knock-down;Knowledge;Laboratories;Length;Link;Liquid substance;Lyssavirus;Mesenchymal;Methods;Mission;mouse model;Mouse Strains;Mus;mutant;nanoengineering;National Institute of Neurological Disorders and Stroke;nerve stem cell;Nervous System;Nervous System Disorder;Neurodegenerative Disorders;neurogenesis;Neurons;neuropathology;neuroprotection;neurorestoration;next generation sequencing;novel;novel therapeutics;NuRD complex;oxidative damage;Pathway interactions;patient derived induced pluripotent stem cells;Patients;phase I trial;Phase III Clinical Trials;Positioning Attribute;Precipitation;Precision therapeutics;preservation;Production;Proteins;Protocols documentation;Publishing;rabies virus glycoprotein G;Recovery;recruit;Repression;Reproducibility;Research;restoration;RNA;Rodent Model;Route;Safety;Signal Pathway;Signal Transduction;Spinal Cord;stem;stem cell delivery;Stromal Cells;Techniques;Technology;Testing;Therapeutic;therapy development;tool;transcription factor;Transcription Repressor;Transgenic Organisms;Tropism;Up-Regulation;Validation;Variant;vector;Vesicle;Vesicular stomatitis Indiana virus;Work;Zinc Fingers

PROJECT_TITLE: MSCS ENGINEERED TO PRODUCE BDNF AND GENE EDITING CARGO FOR THE TREATMENT OF HUNTINGTON'S DISEASE

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Eye Disease and Disorders of Vision

ORG_CITY: AMHERST

ORG_DEPT: DENTISTRY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: Project narrative The proposed project has important implications for public health, as it will address key mediators of immune dysfunction both locally and systemically in Sjögren’s syndrome. We expect this study to result in identification of novel disease mechanisms that can be targeted to improve the treatment of Sjögren’s syndrome, leading to improved oral and systemic health for individuals afflicted with this debilitating disease.

PI_NAMEs: KRAMER, JILL MARIE (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Affect;Agonist;Autoimmune;Autoimmune Diseases;Autoimmunity;Automobile Driving;B-Cell Activation;B-Lymphocytes;Biological Models;Biological Response Modifiers;Blood Cells;Cell Nucleus;cell type;Cells;Chronic;conditional knockout;curative treatments;cytokine;Cytokine Network Pathway;Data;Development;Diagnosis;Disease;Early Diagnosis;Endosomes;Etiology;Event;Exhibits;Exocrine Glands;Family;Family member;Health;Hematopoietic;Immune;immune activation;Immune mediated destruction;Immune system;Immune System Diseases;improved;Individual;Inflammation;Inflammation Mediators;innovation;insight;Interleukin-1;Interleukin-1 Receptors;Knock-out;Laboratories;lacrimal;Lacrimal gland structure;Liquid substance;Lupus;Mediating;Mediator;member;Modeling;morphogens;mouse model;Mus;Myelogenous;novel;Oral;palliative;Pathogenesis;Pathway interactions;Patients;peripheral blood;Proteins;Public Health;receptor;Reporting;Research;response;Rest;Role;Saliva;Salivary;Salivary Gland Tissue;Salivary Glands;Sampling;Seminal;Signal Pathway;Signal Transduction;Sjogren's Syndrome;Symptoms;Systemic disease;systemic inflammatory response;Testing;Therapeutic;therapeutic development;Tissues;TLR7 gene;Toll-like receptors

PROJECT_TITLE: Analysis of MyD88-mediated immune activation in Sjogrens syndrome pathogenesis

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Breastfeeding, Lactation and Breast Milk;Clinical Research;Complementary and Integrative Health;Depression;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Serious Mental Illness;Women's Health Research

ORG_CITY: Bloomington

ORG_NAME: HEALTHPARTNERS INSTITUTE

PHR: PROJECT NARRATIVE Up to 12% of pregnant women experience a new episode of depression during pregnancy, but less than half of these women initiate psychotherapy (ie, talk therapy) or antidepressant use. The goals of this study are to identify factors that predict whether pregnant women with new episodes of depression initiate psychotherapy or antidepressant use and to assess the effects of these treatments on their infants (including preterm birth, low birth weight, small for gestational age birth) and breastfeeding continuation (at 1 week, 2 months, and 6 months after delivery) while accounting for depression severity. This study will inform our understanding of the ways in which pregnant women cope with depression and has the potential to improve decision making for optimal depression management during pregnancy.

PI_NAMEs: PALMSTEN, KRISTIN  (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: Accounting;Acupuncture Therapy;antenatal;antepartum depression;anti-depressive agents;Benefits and Risks;Birth;Blood flow;Breast Feeding;Cessation of life;Characteristics;clinical decision-making;comorbidity;Complementary and alternative medicine;coping;Data;Decision Making;demographics;Depression screen;depressive symptoms;Dose;electronic health data;Emotional;Epidemiologic Methods;ethnic diversity;experience;Goals;Guidelines;Immunosuppression;improved;Infant;infant outcome;instrument;Internet;Intervention;Low Birth Weight Infant;Maternal Behavior;maternal comorbidity;maternal depression;Mediator;Mental Depression;Mental Health;novel;Observational Study;offspring;Outcome;Pattern;peer support;Perinatal;perinatal outcomes;Persons;Pharmaceutical Preparations;Phototherapy;Placenta;Population;Positioning Attribute;Postpartum Period;Predictive Factor;Pregnancy;Pregnancy Complications;Pregnant Women;Premature Birth;Problem behavior;Provider;Psychotherapy;Publishing;racial diversity;Randomized, Controlled Trials;Recurrence;response;Risk;Risk Factors;screening;Self Care;Self-Injurious Behavior;Severities;Site;Small for Gestational Age Infant;Smoking;substance use;Support Groups;Surveys;Symptoms;treatment effect;treatment optimization;Woman;Women's study;Yoga

PROJECT_TITLE: Treatment Initiation for New Episodes of Depression in Pregnant Women

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Health Services;Patient Safety;Prevention

ORG_CITY: ATLANTA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Hyperglycemia in the hospital is common and has been associated with increased hospital complications, length of stay, and mortality. Insulin therapy has been shown in randomized controlled trials to be effective reducing hyperglycemia and hospital complications but is cumbersome and contributes to rising health care costs. We propose a randomized controlled trial to assess whether continuation of home oral antidiabetic agents during hospitalization can be used as a safe and effective alternative to insulin therapy in the management of diabetes in the hospital.

PI_NAMEs: FAYFMAN, MAYA  (contact)

PROGRAM_OFFICER_NAME: GOROSPE, RAFAEL

PROJECT_TERMS: Admission activity;Adult;Advisory Committees;Agonist;Anti-diabetic Drugs;basal insulin;Biometry;Blood Glucose;Bolus Infusion;Cardiovascular system;career;career development;Clinical;clinical care;Clinical Investigator;Clinical Trials;Collaborations;comparative efficacy;Complex;Continuous Glucose Monitor;cost;Critical Illness;Data;Development Plans;diabetes management;Diabetes Mellitus;diabetes mellitus nursing;Dipeptidyl Peptidases;Discipline of Nursing;Drug usage;Economics;efficacy evaluation;Emergency department visit;experience;GLP-I receptor;Glucose;glycemic control;Goals;Guidelines;Health Care Costs;health economics;Healthcare Fees;Home;Hospital complications;Hospital Costs;Hospital Mortality;hospital readmission;Hospitalization;Hospitals;Hyperglycemia;Hypoglycemia;Iatrogenesis;improved;inhibitor;Injections;Inpatients;Institution;Insulin;Interdisciplinary Study;Kidney;Length of Stay;Lung;Measures;Medical;Medicine;Mentors;Metformin;mortality;Multiple Organ Failure;new technology;Non-Insulin-Dependent Diabetes Mellitus;novel;Observational Study;Operative Surgical Procedures;optimal treatments;Oral;Outcome;Patient Admission;Patient Preferences;Patients;Pharmacotherapy;point of care;Pragmatic clinical trial;preference;prospective;Prospective Studies;Randomized;Randomized Controlled Clinical Trials;Randomized, Controlled Trials;Recommendation;Regimen;Reporting;Research;Research Training;Risk;Safety;Services;standard of care;subcutaneous;Sulfonylurea Compounds;Surveys;Systemic infection;Technology;Thiazolidinediones;Time;tool;Training;Work

PROJECT_TITLE: Use of Non-Insulin Agents  in Hospitalized Patients with Type 2 diabetes (T2D)

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: NEW YORK

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE As the face of the overdose crisis changes, focused attention on marginalized populations and the social conditions affecting overdose is critically important to forestall deaths and reduce widening inequities. The proposed study uses a stepped wedge cluster randomized controlled trial and qualitative interviews to examine the implementation of evidence based practices to prevent overdose in permanent supportive housing— housing that serves formerly homeless individuals who face disproportionately high risk for overdose—in New York City and New York’s Capital Region. Findings will lay the groundwork for widespread implementation of overdose prevention practices in permanent supportive housing, as well as inform similar implementation efforts for other housing settings that serve at-risk populations.

PI_NAMEs: DORAN, KELLY  (contact)

PROGRAM_OFFICER_NAME: MULFORD, CARRIE FRIED

PROJECT_TERMS: Address;Adoption;Affect;American;Attention;Biometry;Capital;Case Management;Categories;Cessation of life;Characteristics;Chronic;Clinical;Collaborations;community based participatory research;COVID-19 pandemic;Data;demographics;design;disparity reduction;Dissemination and Implementation;Education;Effectiveness;effectiveness/implementation study;Environment;Environmental Risk Factor;Epidemiology;evidence base;Evidence based practice;experience;Exploration, Preparation, Implementation, and Sustainment;Face;Focus Groups;future implementation;Goals;Harm Reduction;Health;high risk;Homeless persons;Homelessness;Hospitals;Housing;Hybrids;implementation barriers;implementation efforts;implementation evaluation;implementation facilitators;implementation framework;implementation intervention;implementation outcomes;implementation science;implementation strategy;improved;Individual;Inequity;Intervention;Interview;Learning;marginalized population;Medicaid;medication for opioid use disorder;Mental disorders;Mental Health;Methodology;Modeling;mortality;multidisciplinary;New York;New York City;novel;Outcome;Outpatients;Overdose;overdose prevention;Overdose reduction;overdose risk;Persons;Phase;Policies;Policy Maker;Populations at Risk;Preparation;prevent;prevention practice;primary outcome;Public Housing;Qualitative Research;Questionnaires;randomized controlled design;Randomized, Controlled Trials;Research;Research Personnel;research to practice;Risk;Risk Factors;Safety;Services;Shelter facility;Social Conditions;social health determinants;Strategic Planning;Substance Use Disorder;success;supported housing;Surveys;Testing;Time;United States;uptake;Work

PROJECT_TITLE: Implementation of Overdose Prevention Practices in Permanent Supportive Housing

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_DEPT: PATHOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE: The medial ganglionic eminence (MGE) is a progenitor domain in the ventral telencephalon that generates both locally-projecting interneurons and long-distance projecting projection neurons; how this delineation occurs is currently unknown. We have identified a transcription factor, St18 that strongly biases MGE progenitors to pro- jection neuron identity. We will examine how St18 does so in gain- and loss-of-function studies as well as at the molecular level.

PI_NAMEs: AU, EDMUND  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Ablation;Address;Adopted;Axon;Biological Models;Cell Nucleus;Cells;ChIP-seq;chromatin immunoprecipitation;Collection;Competence;conditional mutant;Defect;Development;directed differentiation;Distal;Dorsal;Doxycycline;Dyes;gain of function;Gene Expression;Gene Expression Profiling;gene network;Genes;Genetic Transcription;Globus Pallidus;Histology;Image;in utero;in utero transplantation;In Vitro;in vitro Assay;in vitro Model;in vitro testing;in vivo;in vivo evaluation;in vivo Model;insight;Interneurons;Label;loss of function;Maps;Measures;Medial;migration;Migration Assay;Modeling;Molecular;Molecular Probes;Morphogenesis;Morphology;motor control;mouse genetics;Mus;mutant;Mutant Strains Mice;nerve stem cell;Nervous System;Neurites;Neurons;novel marker;Pars Externa;Pathway interactions;Periodicity;Population;Positioning Attribute;Process;Production;progenitor;Prosencephalon;Regulation;Repression;Sequence Analysis;single-cell RNA sequencing;Specific qualifier value;stem cell differentiation;System;Techniques;Telencephalon;Testing;Thalamic structure;Time;transcription factor;transcriptome sequencing;Transplantation;Viral

PROJECT_TITLE: Studying the Molecular Regulation of MGE Projection Neuron Identity by St18

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Inflammatory Bowel Disease;Microbiome

PI_NAMEs: CHERVONSKY, ALEXANDER V (contact)

PROJECT_TERMS: Address;Animals;Appointment;Area;Autoimmune Diseases;base;Biochemical;Biological Sciences;Cells;Censuses;Chicago;Clinical;commensal microbes;Communities;Complex;Control Animal;cost effectiveness;Data Set;Derivation procedure;Development;Digestive System Disorders;Disease;DNA sequencing;Enteral;Experimental Models;experimental study;Faculty;Food Hypersensitivity;Functional disorder;Funding;Genome;Germ-Free;Gnotobiotic;Goals;gut microbes;gut microbiome;gut microbiota;Habitats;Health;high standard;host-microbe interactions;Human;human microbiota;Immunologist;Immunology;in vivo;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;innovation;Institution;Instruction;Interdisciplinary Study;Investigation;Joints;Knowledge;Laboratories;Laboratory Animal Production and Facilities;large datasets;Life;Link;Maintenance;member;Metagenomics;Methods;Microbe;microbial;microbial community;microbial disease;Microbiology;microbiota;Mucous Membrane;Mus;mutualism;next generation;Obesity;Organ;Patients;Personal Satisfaction;Physiology;Play;Price;Procedures;Property;Publications;Quality Control;Research;Research Personnel;Role;Sampling;Savings;Scientist;Secure;Services;Shapes;Shotguns;square foot;Structure;Surveys;synergism;System;Technology;Testing;Tissues;Training and Education;Universities;Work

PROJECT_TITLE: Host-Microbe Core (HM)


NIH_SPENDING_CATS: Digestive Diseases;Liver Disease

ORG_CITY: PHILADELPHIA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative: Tubular bile canaliculus formation is critical to liver function. Defects in this process are associated with serious liver diseases such as cholestasis and hepatocarcinoma. Thus, our proposed study on the mechanisms of tubular bile canaliculus formation is fundamentally important not only for basic research but also for public health.

PI_NAMEs: BI, ERFEI  (contact)

PROJECT_TERMS: Actin-Binding Protein;Actins;Adherens Junction;Affect;Apical;Architecture;Attenuated;Basic Science;Bile fluid;Binding;Biogenesis;Biology;Blood Circulation;Candidate Disease Gene;Cell model;Cells;Cholestasis;cytohesin-1;Cytokinesis;Cytoskeleton;daughter cell;Defect;Development;Drug Metabolic Detoxication;Epithelial Cells;Epithelium;Excretory function;Exocytosis;Filament;gene discovery;Gene Expression Profile;Genes;Geometry;Gold;Growth;Guanine Nucleotide Exchange Factors;Hepatic Cord;Hepatocyte;Human;In Vitro;in vivo;interdisciplinary approach;Kinesin;Link;Liver;liver development;Liver diseases;liver function;Location;Mediating;Membrane;Metabolism;Microfilaments;Microtubules;Motor;Myosin Type V;Natural regeneration;Organ;Pathway interactions;Phosphatidylinositols;Play;Plus End of the Microtubule;Primary carcinoma of the liver cells;Process;Production;Proliferating;Public Health;Rattus;Recycling;Role;scaffold;Scaffolding Protein;Serum Proteins;Side;Site;Small Interfering RNA;spatiotemporal;Surface;Testing;Tight Junctions;Time;trafficking;transcriptomics;Tube;Tubular formation;Vesicle;vesicle transport;Visceral

PROJECT_TITLE: Mechanisms of Hepatocyte Polarization and Apical Tube Formation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-C(02)M]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Food Allergies;Nutrition

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE Eosinophilic esophagitis (EoE), a recently recognized disease with rapidly increasing incidence, prevalence, and recognition, is characterized by the abnormal presence of eosinophils in the esophageal lining, leading to difficulty swallowing, progressive esophageal stenosis, and food impaction. The goals of this pilot/feasibility project are to estimate the effect of allergen-specific immune signature-directed dietary elimination compared to sham elimination on esophageal eosinophil counts and symptoms of dysphagia in patients with EoE, and assess serum eosinophil peroxidase as a non-invasive biomarker to estimate effect sizes for monitoring dietary elimination treatment response in patients with EoE. The proposed research will set the stage for a definitive clinical that will impact the treatment and monitoring of EoE by individualizing dietary elimination and streamlining monitoring of dietary elimination using non-invasive biomarkers, so patients can avoid the time, effort, and risk of repeated endoscopies to identify dietary triggers.

PI_NAMEs: DELLON, EVAN SAMUEL (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Acceleration;Address;Adherence;Aftercare;Algorithms;Allergens;Biological Assay;Biological Markers;Biopsy;Blood;blood-based biomarker;CD4 Positive T Lymphocytes;Chronic Disease;Clinical;Clinical Trials;Consumption;Control Groups;Data;Deglutition;Deglutition Disorders;design;Diet;Diet Monitoring;Diet therapy;dietary;Digestive System Disorders;Disease;Endoscopy;eosinophil;eosinophil peroxidase;Eosinophilic Esophagitis;eosinophilic inflammation;Esophageal mucous membrane;Esophageal Stenosis;Esophagus;Feasibility Studies;feasibility testing;feasibility trial;Food;Food Hypersensitivity;Foundations;Future;gastrointestinal;Goals;Histologic;Hypersensitivity;IgG4;Immune;Incidence;individual patient;Infiltration;innovation;Knowledge;Measures;Mediating;Monitor;Morbidity - disease rate;multidisciplinary;NIH Program Announcements;Nonpharmacologic Therapy;novel;Outcome;Pathology;Patients;peripheral blood;Pharmaceutical Preparations;Placebo Control;Prevalence;procedure cost;Process;randomized, clinical trials;Reproducibility;Research;Research Project Grants;response;Risk;Serum;Skin;Symptoms;Techniques;Testing;Time;Translational Research;treatment response;United States National Institutes of Health

PROJECT_TITLE: An allergen-specific immune signature-directed diet vs sham diet for treatment of eosinophilic esophagitis:  A pilot-feasibility study

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


NIH_SPENDING_CATS: Clinical Research;Kidney Disease

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Chronic kidney disease continues to be a significant factor in global morbidity and mortality. Therapeutic options halting progression from acute kidney injury to chronic kidney disease still represent an unmet need. Here we will study the roles of complement component 5 receptor 1 activation in kidney tubular cells and myeloid cells after kidney injury.

PI_NAMEs: YU, MON-WEI  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: 3-Dimensional;Acceleration;Actins;Acute;Acute Renal Failure with Renal Papillary Necrosis;Adenosine Triphosphate;Adult;Affect;Animals;antagonist;Apoptosis;Area;Aristolochic Acids;Autoimmune Diseases;Awareness;Big Data;Biology;C5a anaphylatoxin receptor;career;career development;Cell Aging;Cell Cycle Arrest;cell injury;Cell Survival;Cells;Chronic Kidney Failure;Clinical;Complement;Complement 5a;Complement Activation;Complement component C5;Data;Data Analyses;design;Development;Disease Progression;End stage renal failure;Environment;Epithelial Cells;experience;experimental study;Faculty;Fibrosis;Foundations;Future;Genetic;Glycolysis;Grant;Hallmark Cell;Health;Histologic;Homeostasis;Hospitals;Human;Immune;Immunologics;Immunology;In Vitro;in vivo;Infection;Infiltration;Inflammasome;Inflammation;Inflammatory;Injury;Injury to Kidney;innovation;K-Series Research Career Programs;Kidney;Kidney Diseases;kidney fibrosis;Kidney Transplantation;Knowledge;Lead;Length of Stay;Macrophage;Manuscripts;Mediating;medical schools;Metabolic;mitochondrial dysfunction;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Myeloid Cell Activation;Myeloid Cells;Nephrology;novel;novel marker;Organoids;Outcome;Oxygen;Pathogenesis;Patients;Phagocytes;Phagocytosis;Phase;Population;Preparation;Prevalence;prevent;Production;profibrotic cytokine;Reactive Oxygen Species;receptor;Recovery;recruit;Role;Scientist;senescence associated secretory phenotype;Signal Transduction;single cell analysis;skills;Smooth Muscle;Solid;Techniques;Testing;Therapeutic;Tissues;tool;Training;Training Activity;Tubular formation

PROJECT_TITLE: Unanticipated roles of C5aR1 Signaling Leading from Acute to Chronic Kidney Disease

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Childhood Obesity;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Diabetes;Maternal Health;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Women's Health Research

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

PHR: PROJECT NARRATIVE Research on human milk composition and the lactational influences on offspring health after gestational exposures are lacking. The proposed research will study how human milk nutrient profiles susceptible to maternal metabolism and diet during pregnancy and lactation impact offspring growth. Understanding the functional implications of human milk composition on children at risk of adverse metabolic health is relevant to public health and the NIH/NICHD priority for human milk research.

PI_NAMEs: GREGG, BRIGID ELLEN;JOSEFSON, JAMI L (contact);ROBINSON, DANIEL T.

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: 2 year old;Accounting;Address;adipocyte differentiation;Adipocytes;adverse pregnancy outcome;Anabolism;Ancillary Study;Beta Cell;Body Composition;Body fat;Body mass index;Breast Epithelial Cells;Breast Feeding;cardiometabolic risk;Categories;Cells;Child;Childhood;cohort;Development;Diet;Dissection;early childhood;Enrollment;Environment;Epithelial Cells;experience;Exposure to;Fatty Acids;Follow-Up Studies;Food;Functional disorder;Funding;Gene Expression;Gene Expression Profile;Gestational Diabetes;Glucose;Glucose Metabolism Disorders;Goals;Growth;Health;high body mass index;Human;Human Milk;Hyperglycemia;Hypertrophy;improved;in utero;in vitro testing;Infant;infant adiposity;Insulin Resistance;inter-individual variation;Intervention;Knowledge;Lactation;lactation period;lactogenesis;Length;Linoleic Acids;Linolenic Acids;lipid biosynthesis;Lipids;Mammary gland;mammary gland development;maternal condition;maternal diabetes;maternal hyperglycemia;maternal obesity;Measures;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolism;Milk;Modeling;mother nutrition;Mothers;National Institute of Child Health and Human Development;novel;Nutrient;nutrition;Obesity;obesity in children;offspring;Outcome;Palmitic Acids;Pathologic;Pathway interactions;Phenotype;post pregnancy;Postpartum Period;Predisposition;Pregnancy;prenatal exposure;prospective;Public Health;Regulation;Reproducibility;Research;response;Risk;Risk Reduction;Sampling;Scientist;screening;Shapes;Testing;Time;transcriptomics;Translational Research;translational study;United States National Institutes of Health;Validation;Variant;Weight;Woman

PROJECT_TITLE: The GROWTH Study, Glycemia Range and Offspring Weight and adiposity in response To Human milk

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE Despite the existence of antiretroviral therapies (ARTs) that can keep the virus at bay for extended periods of time, there exist an actively growing population of HIV-1 infected patients as well as issues of compliance and resistance complicating current treatment. Therefore, there exists an active need to study HIV biology to identify therapeutic targets in areas currently less understood, which is why the focus of this study is RNA-related processes, specifically focused on genome dimerization. Successful completion of this proposal will give us a greater understanding of the mechanism of HIV-1 genome dimerization, a critical step to viral replication and genome packaging, while also clarify the role HIV-1 sequence variation has on this process.

PI_NAMEs: YASIN, SAIF  (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Address;Anti-Retroviral Agents;antiretroviral therapy;Area;Biological;Biological Assay;Biology;biophysical properties;Cell membrane;Cells;Color;Cytoplasm;Data;data quality;Diffusion;dimer;Dimerization;Discrimination;Dissociation;Equilibrium;Exhibits;Fluorescence;Fluorescence Resonance Energy Transfer;gag Gene Products;Gel;gel electrophoresis;Genetic Recombination;Genetic Transcription;Genome;Goals;HIV;HIV Genome;HIV-1;Image;Impairment;In Vitro;intermolecular interaction;Kinetics;Label;Length;Location;Mediating;Membrane;Methods;Modeling;Molecular;Monitor;Mutation;Nature;NMR Spectroscopy;novel;novel strategies;Nuclear Magnetic Resonance;Patients;Population;Process;Property;Publishing;Resistance;Retroviridae;Reverse Transcription;RNA;Role;Site;Spectrum Analysis;Structure;System;Therapeutic;therapeutic target;Thermodynamics;Time;Universities;Validation;validation studies;Variant;Viral;Viral Genome;Viral Proteins;Virus;Virus Assembly;Virus Replication;Wisconsin;Work

PROJECT_TITLE: Characterization of HIV-1 Genome Dimerization: A Strain Specific Dimerization Mechanism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F17A-Z(20)]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Inflammatory Bowel Disease

PROJECT_TERMS: Applications Grants;Area;Award;base;Biological;Categories;Chicago;Collaborations;Data;design;Development;Digestive System Disorders;Extramural Activities;Feasibility Studies;Fostering;Funding;Gastroenterology;Grant;gut inflammation;Hepatology;Homeostasis;Human Genetics;improved;Inflammatory Bowel Diseases;innovation;Institution;Interdisciplinary Study;Investigation;Investments;Laboratories;Maintenance;marine;Medicine;Microbiology;multidisciplinary;Nature;nutrition;Operative Surgical Procedures;Pathology;Pediatrics;Pilot Projects;programs;Research;Research Personnel;Research Support;Scholarship;Secure;Talents;Testing;United States National Institutes of Health;Universities

PROJECT_TITLE: Pilot and Feasibility Program


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative New synthetic methodologies that enable the construction of complex chemical structures are crucial for the synthesis of bioactive molecules. The proposed research utilizes amide electrophiles as synthetic building blocks in order to synthesize enantioenriched products with quaternary centers. The chemistry described in this proposal offers new strategies and tactics for use in the chemical synthesis.

PI_NAMEs: TENA-MEZA, ARISMEL  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Amides;Catalysis;Chemical Structure;chemical synthesis;Chemistry;Complex;Coupling;Development;drug discovery;interest;Marketing;Methodology;Methods;Nickel;Organic Chemistry;Organic Synthesis;Pharmaceutical Preparations;Pharmacologic Substance;Play;Process;Reaction;Reporting;Research;Role;small molecule therapeutics;success;Transition Elements

PROJECT_TITLE: Enantioselective Reactions with Amide Electrophiles Utilizing Transition-Metal Catalysis


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: NARRATIVE Complete resection of lung tumors results in decreased tumor recurrence rates and extended patient survival. Surgical guidance with activatable near-infrared fluorophores can enhance detection of millimeter-sized lesions leading to more accurate margin excision and optimal tumor removal. In this application we employ fluorophores targeted to cPLA2α, an enzyme upregulated in lung adenocarcinomas, for their ability to intraoperatively detect small foci of residual tumor and aid in complete tumor excision in canine patients with operable spontaneous lung carcinomas.

PI_NAMEs: DELIKATNY, EDWARD J (contact);SINGHAL, SUNIL

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: Adopted;Animals;arachidonate;Arachidonic Acids;Autopsy;Back;Biochemistry;Biodistribution;cancer cell;Cancer Detection;cancer diagnosis;Cancer Patient;cancer surgery;Canis familiaris;Cause of Death;Cells;Chemotherapy and/or radiation;Client;Clinical;clinical translation;Clinical Trials;cohort;companion animal;comparison control;Complete Blood Count;Contractor;contrast enhanced;Data;Deposition;design;Detection;detection sensitivity;Development;Disease;dodecyldimethylamine oxide;draining lymph node;Drug Kinetics;Enzymes;Esterification;Excision;Exhibits;Failure;Fingers;Fluorescence;fluorescence-guided surgery;Fluorescent Probes;fluorophore;folate-binding protein;Formulation;Goals;good laboratory practice;Histology;Human;hydroxyl group;Image;Image-Guided Surgery;imaging agent;improved;improved outcome;in vivo;Indocyanine Green;Injections;Institution;Investigational New Drug Application;Kinetics;Lesion;Leukotrienes;liposomal formulation;Liposomes;Lung;Lung Adenocarcinoma;Lung Carcinoma;Lung Neoplasms;Lymph Node Dissections;lymph nodes;Malignant neoplasm of lung;Malignant Neoplasms;Maximum Tolerated Dose;Measures;millimeter;mouse model;Mus;Near-infrared optical imaging;Neoplasm Metastasis;neoplastic cell;Non-Small-Cell Lung Carcinoma;Nonmetastatic;novel;operation;Operative Surgical Procedures;Organ;overexpression;Palpation;Pathway interactions;Patients;Periodicity;Phospholipase;Primary Neoplasm;prognostic indicator;Prostaglandins;Quality of life;Radiation therapy;recruit;Recurrence;Recurrent tumor;relapse patients;Residual Neoplasm;Resolution;response;restoration;Safety;scale up;Sensitivity and Specificity;Serum;Signal Transduction;Solid Neoplasm;Staging;Surgeon;surgery outcome;Survival Rate;systemic toxicity;Testing;Time;Topical application;Toxic effect;Toxicology;Tracer;Translating;Translations;tumor;Tumor Tissue;tumorigenesis;United States;Urinalysis;Veterinary Schools;Visual;Work;wound bed

PROJECT_TITLE: Translating phospholipase activatable fluorophores for the sensitive detection of non-small cell lung cancer

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: VA SALT LAKE CITY HEALTHCARE SYSTEM

PHR: Project Narrative: Percutaneous osseointegrated (OI) devices are becoming a viable alternative to socket suspension of artificial limbs. Although patient satisfaction with this device is high, the weaker link is the vulnerable epidermis-to-implant interface, where interfacial epidermis grows down uncontrollably and produces a sinus tract. Literature indicates that percutaneous healing may be directly related to the biocompatibility of the device material, and importantly, the epidermal adhesion and proliferative patterns. The lack of epidermal integration with the device keeps the interfacial epidermal cells in a migrative phenotype. It is believed that the key for preventing epidermally mediated downgrowth is to use surfaces that promote epidermal cells to form adhesion with them. Our in vitro and non-weight bearing animal studies data indicated that sintered fluorapatite (FA) surfaces could induce such adhesion and differentiation of keratinocytes. Thus, this study proposes to test this unique FA-coated surface in a weight-bearing animal model before the clinical introduction.

PI_NAMEs: JEYAPALINA, SUJEE  (contact)

PROJECT_TERMS: Acceleration;Adhesions;Affinity;Amputees;Animal Model;Animals;Apatites;Autopsy;Biocompatible Coated Materials;Biological Assay;biomaterial compatibility;bone;Bone Surface;Bone Tissue;cell motility;Cells;Characteristics;Chemicals;Client satisfaction;Clinical;clinical application;Cobalt;cold temperature;commercialization;Country;crystallinity;Data;Defect;Dental Enamel;Dental Implants;design;Devices;Docking;efficacy evaluation;efficacy testing;Environment;Epidermis;Epithelium;European;Excision;experimental study;Extracellular Matrix;Extracellular Structure;Family suidae;Fibroblasts;fluorapatite;Funding;Gingiva;Goals;Grain;healing;Hearing Aids;Hemidesmosomes;High temperature of physical object;Human;Implant;implantation;improved;In Vitro;in vivo;Infection;infection rate;interfacial;Invaded;keratinocyte differentiation;Limb Prosthesis;Link;Liquid substance;Literature;Longevity;Mediating;Medicine;metallicity;Modeling;Molecular;Mucous Membrane;Nature;novel;Operative Surgical Procedures;osseointegrated implant;Osseointegration;osteoblast differentiation;Osteoblasts;Osteomyelitis;Outcome;Outcome Study;Pathogenicity;patient population;Patient-Focused Outcomes;Patients;Pattern;Phase;Phenotype;Polymerase Chain Reaction;Porosity;preservation;prevent;Property;Prosthesis;Proteins;Quality of life;Rattus;Reporting;Research;Research Design;Resected;RNA;Sampling;seal;Seal and Protect;Second Look Surgery;Sheep;sheep model;Sinus;Site;Skin;soft tissue;Stomas;Structure;Surface;surface coating;Suspensions;System;Techniques;Technology;Testing;Thick;Time;Tissues;Titanium;United States Department of Veterans Affairs;Water fluoridation;Weight-Bearing state;Work;wound healing

PROJECT_TITLE: Surface Induced Epithelial Differentiation Improves Percutaneous Device Longevity

STUDY_SECTION_NAME: Rehabilitation Engineering & Prosthetics/Orthotics [RRD5]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Pediatric in-hospital cardiac arrest most commonly occurs in pediatric intensive care units and carries extensive morbidity and mortality making prevention the best approach. Prevention of cardiac arrest events is feasible because children often display warning signs prior to deterioration. This application seeks to address prevention of pediatric in-hospital cardiac arrest through clinical decision support and implementation science.

PI_NAMEs: DEWAN, MAYA L (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: AHRQ Mentored Clinical Scientist Research Career Development Award (K08): Maya Dewan

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease

PI_NAMEs: KUPFER, SONIA  (contact)

PROJECT_TERMS: Area;Biological;Biological Sciences;Biology;Chicago;Collaborations;Communication;Development;Digestive System Disorders;Disease;Education;Electronic Mail;Faculty;Feasibility Studies;Fostering;Gastroenterology;Goals;Grant;Human Resources;improved;Individual;Inflammatory Bowel Diseases;Institution;Interdisciplinary Study;interest;investigator training;Knowledge;Laboratories;Learning;marine;member;Methods;Monitor;multidisciplinary;Newsletter;Participant;Pilot Projects;programs;Research;Research Personnel;Resources;Scientist;Series;Statistical Data Interpretation;Summary Reports;symposium;synergism;Techniques;Training;Training and Education;Training Support;trend;Universities;Update

PROJECT_TITLE: Enrichment Program


NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Brain Disorders;Clinical Research;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Multiple sclerosis is marked by inflammatory brain lesions. Most of these lesions start to heal with time, but a small portion remain chronically active and likely contribute to the brain shrinking at a rate about 2-4 times faster than normal. This project aims to look at how to better identify these lesions, as well as potential treatment approaches to halt the chronic inflammation.

PI_NAMEs: HEMOND, CHRISTOPHER C. (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Acceleration;Acute;Acute Disease;Affect;Age;alemtuzumab;American;Antioxidants;Appearance;Area;Biological Markers;Brain;career;Caring;Cells;Central Nervous System;cerebral atrophy;Chronic;Cladribine;Clinical;Clinical Data;clinically relevant;cohort;Complex;Data;Data Set;Databases;Demyelinations;Development;Diagnosis;disability;Disease;Enrollment;follow-up;Fumarates;Goals;healing;Histologic;Histopathology;Image;Immune;immune reconstitution;improved;in vivo;Individual;Inflammation;Inflammatory;insight;Investigation;Iron;K-Series Research Career Programs;Learning;Lesion;Link;Longitudinal cohort;Macrophage;magnetic field;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Maps;Mediating;Mentorship;Microglia;multimodality;Multiple Sclerosis;Multiple Sclerosis Lesions;multiple sclerosis patient;Nerve Degeneration;Nervous System Disorder;Neuroglia;neuroinflammation;novel;Outcome;oxidative damage;Pathology;Patients;personalized predictions;pharmacologic;Phase;Phenotype;potential biomarker;predictive modeling;Predisposition;Prevalence;prevent;Process;Property;prospective;Protocols documentation;Recording of previous events;Records;Recurrence;Research;Resolution;Role;Severities;Severity of illness;Signal Transduction;Spinal Cord;Statistical Data Interpretation;Statistical Models;success;Techniques;Time;tool;Training;translational approach;Translations;Treatment Efficacy;Validation;Visualization

PROJECT_TITLE: MRI Paramagnetic Rim Lesions as Biomarkers and Agents of Neurodegeneration in Multiple Sclerosis

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ADMINISTERING_IC: EY

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences;Social Determinants of Health

ORG_CITY: LA JOLLA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE There is a critical need for more physician scientists engaged in ophthalmology and vision research, and particularly those from traditionally underrepresented backgrounds. This research training program is intended to increase the number and diversity of medical students who have interest and experience in research relevant to ophthalmology and vision science. Through a combination of direct firsthand mentored research training, didactic activities, career development, and networking activities, this program will expand and diversify the ophthalmology research workforce to better meet the needs of an increasingly diverse population of patients suffering from ophthalmic conditions.

PI_NAMEs: BAXTER, SALLY LIU (contact);ZANGWILL, LINDA M

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Advisory Committees;Area;bench to bedside;Biomedical Engineering;biomedical informatics;Biometry;California;Clinical Research;clinical training;Communication;Country;Department chair;design;Development;disability;disadvantaged background;Discipline;Doctor of Philosophy;Drug Delivery Systems;Education;ethnic minority population;experience;Eye;Faculty;Family;Genetic;Grant;hands on research;Health;Image;Image Analysis;Instruction;Interdisciplinary Study;Journals;Leadership;lectures;medical schools;Medical Students;Mentors;Ophthalmology;Oral;Physicians;posters;Program Evaluation;programs;Proteomics;Qualifying;racial minority;Research;Research Ethics;Research Personnel;Research Training;Residencies;Scientist;skills;social media;Structure;Student recruitment;summer research;symposium;Training;Training Programs;Translational Research;Underrepresented Students;United States National Institutes of Health;Universities;Vision;Vision research;web site;Work;Writing

PROJECT_TITLE: Short-Term Research training In Vision and Eye health (STRIVE)


ORG_DEPT: NEUROSCIENCES

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Narrative This research will elucidate basic molecular mechanisms that regulate neurotransmitter receptor function, synaptic transmission, plasticity and learning and memory in the brain but it also has broad relevance for many brain disorders. Dysfunction of neurotransmitter receptor function, synaptic transmission and synaptic plasticity underlies many neurological and psychiatric diseases. This research may therefore reveal novel targets for the development of therapeutic treatments for several disorders including pain, drug addiction, schizophrenia, autism, intellectual disability and Alzheimer's and Parkinson's disease.

PI_NAMEs: HUGANIR, RICHARD L (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Alzheimer's Disease;AMPA Receptors;autism spectrum disorder;Avoidance Learning;Behavioral;Biochemical;Biochemical Process;Biotin;Biotinylation;Brain;Brain Diseases;brain tissue;C-terminal;Catalogs;Cell Culture Techniques;cell type;Chemicals;Chimeric Proteins;Complex;conditional knockout;Cytoplasmic Tail;Disease;DLG4 gene;Drug Addiction;Electrophysiology (science);experimental study;extracellular;Functional disorder;Glutamate Receptor;GRIP1 gene;GRIP2 gene;Hippocampus;In Vitro;in vivo;Injections;Intellectual functioning disability;interest;Knockout Mice;Label;Learning;Ligand Binding Domain;Ligase;Long-Term Potentiation;Maps;Mass Spectrum Analysis;Membrane;Memory;Mental disorders;Modeling;Molecular;Mus;N-terminal;Nervous System Disorder;Neurons;neuropsychiatric disorder;Neurotransmitter Receptor;novel;Pain;Parkinson Disease;Pathway interactions;Physiological;postsynaptic;Postsynaptic Membrane;Process;Property;protein complex;protein protein interaction;Proteins;Proteomics;Radial;receptor;receptor function;Regulation;Research;response;Rodent Model;Role;Schizophrenia;Slice;Stimulus;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;Techniques;Technology;Tertiary Protein Structure;Therapeutic;therapeutic development;trafficking;Training;Virus;Work

PROJECT_TITLE: The Dynamic AMPA Receptor Interactome During Plasticity and Learning

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Clinical Research;Genetics;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Social Determinants of Health

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Project Narrative Recent studies on mice show that the effects of extreme stress in males can be transmitted across multiple generations through environment-induced changes in sperm micro RNAs (miRs) across multiple generations that influence embryo development upon fertilization. Here, we will attempt to add support for this concept in humans by expanding our recent published work that implicated sperm miRs-34c/449a in this process in both mice and men. We will 1) test which types of trauma affect these sperm miRNAs in men, 2) test the possibility that reduced levels of these sperm miRNAs might be a markers for early life or adult exposures to trauma and/or their effects in men and 3) search for evidence that fathers exposed to trauma transmit both reduced levels of these sperm miRNAs to their sons, as well as elevated symptoms of anxiety/depression and/or PTSD to their sons and/or daughters.

PI_NAMEs: FEIG, LARRY  (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Accounting;Adult;adverse childhood events;Affect;Animals;Anxiety;anxiety symptoms;Behavior;Brain;brain abnormalities;Child;Chronic;Daughter;Development;Disease;Disease susceptibility;Early-life trauma;Embryo;Embryonic Development;Environment;Epigenetic Process;experience;Exposure to;Family;Fathers;Female;Fertility;Fertilization;Generations;Human;Inherited;Knockout Mice;Life;male;Male Adolescents;Mediating;men;Mental Depression;Mental disorders;MicroRNAs;Modeling;mouse model;Mus;novel;offspring;Parents;Phenotype;Post-Traumatic Stress Disorders;Predisposition;Process;Publications;Publishing;Questionnaires;Recording of previous events;Reporting;Risk;Role;Severities;Sister;social;Son;sperm cell;Stress;stressor;Symptoms;Testing;Time;trait;transgenerational epigenetic inheritance;transmission process;Trauma;trauma exposure;Work;zygote

PROJECT_TITLE: Potential Role for Sperm miRNAs 34c and 449a in the Transgenerational Effects of Trauma in Men

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Psychosis;Schizophrenia;Serious Mental Illness

PHR: Project Narrative Psychotic Spectrum Disorders (PSD) are severe mental syndromes associated with significant lifelong impairment and high prevalence. In this proposal we aim to employ non-invasive imaging technologies to test that deficiency in brain iron, an essential element for brain functioning, is a feature of PSD. The results of this study may provide new targets for treatments aimed at alleviating psychotic symptoms and cognitive dysfunction in PSD patients.

PI_NAMEs: LAZAR, MARIANA  (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Address;Adolescence;Adult;Affect;Anemia;Aphasia;Area;Biological;Blood;Brain;brain abnormalities;Brain imaging;brain iron;brain tissue;Chronic disability;Cognition;Cognitive;cognitive ability;Cognitive deficits;cognitive function;cognitive performance;Corpus striatum structure;cost estimate;critical developmental period;Data;Delusions;Development;Diagnosis;Diagnostic;Diet;Disabling;Disease;Disease Outcome;dopamine system;dysmyelination;efficacy evaluation;Elements;Emotions;Etiology;functional outcomes;Future;Globus Pallidus;Goals;gray matter;Hallucinations;Health;High Prevalence;Histologic;histological studies;Homeostasis;Image;imaging study;Imaging technology;Impaired cognition;Impairment;improved;in vivo;in vivo imaging;Incidence;Individual;infancy;insight;Interview;Iron;iron deficiency;iron metabolism;Knowledge;Life;Light;Literature;Magnetic Resonance Imaging;Magnetism;Maintenance;MATRICS Consensus Cognitive Battery;Measures;Modeling;Myelin;myelination;Neurobehavioral Manifestations;neuromechanism;Neurotransmitters;non-invasive imaging;novel;Oligodendroglia;Outcome;Pathogenesis;Pathway interactions;Patients;Perception;peripheral blood;Pharmaceutical Preparations;Play;Population;prenatal;Process;Protons;Psyche structure;Psychoses;psychotic;psychotic symptoms;Relaxation;remediation;Research;Role;Schizoaffective Disorders;Schizophrenia;Serotonergic System;Structure;Symptoms;Syndrome;System;T2 weighted imaging;Testing;Thalamic structure;timeline;treatment strategy;white matter;Work;young adult

PROJECT_TITLE: Iron deficits and their relationship with symptoms and cognition in Psychotic Spectrum Disorders

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dietary Supplements;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Project Narrative The goal of this project is to use a two-stepped study to examine both the adoption of the three dietary patterns as presented by the United States Dietary Guidelines (USDG) and testing of a refined, culturally-tailored one- year intervention examining the three diet patterns. For this study, African American adult participants with overweight/obesity and ≥three type 2 diabetes (T2DM) risk factors will be recruited to participate in this two- step study. Step 1: formative pilot work to culturally-tailor a dietary intervention of the three healthy eating patterns presented by the USDG for 12 weeks: 1) U.S.-Style, 2) Mediterranean, or 3) Vegetarian and Step 2: Using the findings from Step 1, conduct a one-year intervention using revised culturally tailored materials to examine differences in diet quality and T2DM risk factors among participants randomized to one of the 3 dietary patterns.

PI_NAMEs: TURNER-MCGRIEVY, GABRIELLE MICHELLE (contact)

PROGRAM_OFFICER_NAME: RAJAPAKSE, NISHADI

PROJECT_TERMS: Address;Adopted;Adoption;Adult;African American;African American population;African ancestry;bean;Biological;burden of chronic illness;Communication;Communities;community intervention;cooking;Diabetes Mellitus;diabetes risk;Diet;dietary;Dietary Fiber;dietary guidelines;Dietary Intervention;Dietary Practices;Eating;Ensure;European;evidence base;experience;Failure;Food;fruits and vegetables;Future;Genetic Predisposition to Disease;Goals;good diet;Guidelines;Health;Healthy Eating;Hispanic Populations;Hypertension;improved;indexing;Individual;Industry;Intake;Intervention;Intervention Trial;LDL Cholesterol Lipoproteins;Literature;Measures;Non-Insulin-Dependent Diabetes Mellitus;Nutrient;nutrition;Nutritional;Nutritional Study;Obesity;Observational Study;Odds Ratio;Overweight;Participant;Pattern;Persons;Phase;Plants;Policies;Population;Population Heterogeneity;programs;Randomized;randomized trial;Recipe;Recommendation;recruit;Research;response;Restaurants;Risk;Risk Factors;Testing;United States;Update;Vegan Diet;Weight;Work

PROJECT_TITLE: Ensuring the cultural relevance of Dietary Guidelines diet patterns among African Americans: Increasing dietary quality and reducing type 2 diabetes risk

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Nanotechnology;Regenerative Medicine

PHR: Project Narrative  The proposed research seeks to understand the mechanism(s) by which a novel nanofiber-hydrogel composite material is remodeled in vivo into vascularized soft tissue by infiltrating host cells. Additionally, we will optimize its formulation to develop an improved off-the-shelf material with enhanced capacity to achieve natural tissue restoration.

PI_NAMEs: STELZEL, JESSICA  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Adipocytes;angiogenesis;Autologous;Biocompatible Materials;Blood Vessels;candidate identification;Cell Therapy;cell type;Cells;clinical translation;conditioning;Coupled;Data;Defect;Deposition;design;Engineering;Extracellular Matrix;Fibrosis;Foreign Bodies;Formulation;Goals;Growth Factor;Health Care Costs;Heterogeneity;Hydrogels;Immune;Immune response;immunoregulation;implantation;improved;In Vitro;in vivo;Infection;Infiltration;Inflammation;Inflammatory;Injectable;insight;interest;Kinetics;Knock-out;lipid biosynthesis;mechanical properties;migration;Modeling;Morbidity - disease rate;nanoengineering;nanofiber;next generation;novel;Outcome;Pathway interactions;Patients;Property;Prosthesis;psychologic;reconstruction;recruit;regenerative cell;Regenerative Medicine;repaired;replacement tissue;Research;response;restoration;Scientist;Signal Pathway;single-cell RNA sequencing;Site;soft tissue;Structure;Structure-Activity Relationship;System;Techniques;Testing;theories;Time;Tissue Survival;Tissues;translational model;translational potential;Variant;Vascularization;Work

PROJECT_TITLE: Characterization and Optimization of a Nanofiber-Hydrogel Composite for Tissue Remodeling

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Lyme Disease;Prevention;Tickborne Diseases;Vector-Borne Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: NARRATIVE Lyme disease is a significant public health problem in the U.S. One potential approach to the control of Lyme disease is to reduce carriage of the organisms in their wild-life reservoirs. In this proposal, we outline a strategy to develop a new antibiotic that does not cause the development of resistance to antibiotics used for human treatment, to be administered to mice and ticks that serve as the reservoir for the bacteria that causes Lyme disease. By decreasing carriage of the organism in the wildlife reservoirs and vectors, we hope to reduce the incidence of human disease.

PI_NAMEs: HU, LINDEN T (contact);LEWIS, KIM

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: acaricide;Anaplasma;Anaplasma phagocytophilum;Animals;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Area;Awareness;Bacteria;Biology;Borrelia burgdorferi;Clinical;Collaborations;Data;Deer;Development;Diagnosis;Disease;Disease Reservoirs;disorder control;dosage;Dose;Doxycycline;drug development;Drug Kinetics;Eating;efficacy evaluation;Environment;Evaluation;Excision;Experimental Designs;exposed human population;Exposure to;field study;Financial cost;Food;Formulation;Genes;genome sequencing;Geographic Distribution;Geography;Goals;Growth;Habitats;Health;Human;human disease;human pathogen;hygromycin A;Incidence;Infection;Infection Control;infection rate;Ingestion;inhibitor;Island;Ixodes;Laboratories;Lead;Lyme Disease;Mammals;Manufacturer;Marketing;Massachusetts;Measures;microorganism;Modification;Mus;mutant;novel;novel strategies;Oral;Oral Administration;Organism;OspA protein;pathogen;Peptidyltransferase;Peromyscus;Pharmacodynamics;Politics;Population;Population Control;Public Health;Recombinant Proteins;Recovery;Resistance;Resistance development;Resources;Ribosomes;Rocky Mountain Spotted Fever;Rodent;Safety;Salmonella;simulation;Soil;Source;Specificity;stem;Streptomyces;success;Test Result;Testing;Therapeutic;Ticks;Tilia;tool;Toxic effect;transmission process;United States;uptake;Vaccination;Vaccines;vector;vector tick;weapons;whole genome

PROJECT_TITLE: Development and Field Testing of a Novel Reservoir Targeted Antibiotic Against Borrelia burgdorferi


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Cannabinoid Research;Chronic Pain;Complementary and Integrative Health;Natural Products;Neurodegenerative;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Peripheral Neuropathy;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: TUCSON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: NARRATIVE  Terpene compounds from Cannabis sativa have been suggested as non-opioid, non-cannabinoid therapies for pain; however, the literature on their use in pain is limited. In this proposal we will thus rigorously evaluate the therapeutic potential of select terpenes in producing pain relief in neuropathic pain with limited side effects and also determine the molecular mechanism(s) of terpene pain relief. Together these studies will provide a firm translational and basic science basis to move terpene compounds forward to clinical testing for neuropathic pain management.

PI_NAMEs: STREICHER, JOHN MICHAEL (contact)

PROGRAM_OFFICER_NAME: BELFER, INNA

PROJECT_TERMS: Acute Pain;addiction;addiction liability;Adenosine;Affect;Agonist;American;Analgesics;animal pain;antagonist;Anti-Inflammatory Agents;antinociception;Basic Science;Biological Models;Brain;Cannabidiol;cannabinoid treatment;Cannabinoids;Cannabis;Cannabis sativa plant;chemotherapy;Chemotherapy-induced peripheral neuropathy;chronic pain;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;CNR1 gene;CNR2 gene;Complex Mixtures;conditioned place preference;Consumption;CRISPR/Cas technology;Crude Extracts;cytokine;Development;Diabetes Mellitus;Diabetic Neuropathies;Dose;drug development;economic cost;Epidemic;Evaluation;Genes;Health;Human;humulene;improved;In Vitro;in vitro Model;in vivo Model;Inflammation;Inhalation;insight;Investigation;Ligands;linalool;Literature;Measures;Methods;Modeling;Molecular;Morphine;mouse model;nerve injury;Neuropathy;non-cannabinoid;non-opioid analgesic;Opiate Addiction;Opioid;opioid abuse;opioid epidemic;opioid overdose;Oral;Overdose;Pain;Pain management;pain model;pain patient;pain relief;painful neuropathy;Patients;Persons;Pharmaceutical Preparations;Pharmacology;Pharmacopoeias;phytocannabinoid;Plants;preclinical study;prevent;Production;Property;Quality of life;Receptor Activation;Research;research clinical testing;response;Rewards;Role;Route;Sample Size;side effect;Site;Spinal Cord;standard care;synergism;Tail;Terpenes;Testing;Tetrahydrocannabinol;Therapeutic;Therapeutic Effect;Time;Tissues;Translational Research;United States;Ventilatory Depression;Work

PROJECT_TITLE: Therapeutic and Mechanistic Evaluation of Cannabis sativa Terpenes in Neuropathic Pain

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PI_NAMEs: FEGHALI-BOSTWICK, CAROL A. (contact)

PROGRAM_OFFICER_NAME: RADMAN, THOMAS C

PROJECT_TERMS: Applications Grants;Basic Science;Biomedical Research;career;Clinical Research;Clinical Sciences;Coupled;design;Development;Development Plans;Entrepreneurship;Evaluation;experience;Funding;Goals;Grant;improved;Individual;innovation;Interdisciplinary Study;Journals;Learning;Medical;member;Mentors;multiple data sources;National Research Service Awards;next generation;novel;peer coaching;pre-doctoral;programs;Request for Applications;Research;Research Institute;Research Project Grants;Research Training;Science;Scientist;SCTR gene;skills;South Carolina;Training;Training Programs;translational medicine;Translational Research;translational scientist;Universities;Work;Writing

PROJECT_TITLE: NRSA Training Core


NIH_SPENDING_CATS: Genetics;Human Genome;Prevention

ORG_DEPT: BIOLOGY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Most heritable differences among humans, including in disease risks, arise from small genetic differences at numerous genes. Yet we still do not understand how a gene’s contribution to heritable variation in complex traits relates to its importance to the biology of those traits, or how the genetic makeup of the population changes in response to changing selection pressures on complex traits. We will develop mathematical models and conduct data analyses to elucidate these central questions in human and evolutionary genetics.

PI_NAMEs: SELLA, GUY  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;Affect;Alleles;Biology;Complex;Data Analyses;Demography;Dimensions;Disease;disorder risk;Etiology;Evolution;expectation;experience;fitness;Foundations;Frequencies;Gene Frequency;Generations;generative models;Genes;Genetic;genetic evolution;genetic makeup;Genetic Variation;Genome;genome wide association study;genomic data;Grant;Heritability;Human;interest;Learning;mathematical model;Modeling;Natural Selections;Phenotype;pleiotropism;Polygenic Traits;Population;Population Genetics;Predictive Analytics;pressure;Process;Research;response;sample fixation;Shapes;simulation;Testing;Time;trait;Variant;Work

PROJECT_TITLE: The population genetics of disease risk and other quantitative traits

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-P(02)M]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative Developmental and epileptic encephalopathies (DEE) are a devastating group of neuropsychiatric disorders where seizures (that begin early in life) and an underlying genetic mutation or brain lesion result in developmental delay, intellectual disability and a complex spectrum of neurobehavioral disturbances. In this proposal, we apply a mouse model of DEE to clarify the molecular and circuit-level mediators underlying such behavioral syndromes using a novel homecage approach to measuring mouse behavior.

PI_NAMEs: KRISHNAN, VAISHNAV  (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: Ablation;Adult;Affect;Age;anxious;Arousal;Behavior;behavior measurement;Behavior Therapy;Behavioral;Biological Assay;Biological Models;Brain;Brain-Derived Neurotrophic Factor;Calcium;Caregivers;Circadian Rhythms;Clinical Trials;Cognitive;cognitive function;Communication;comorbidity;Complex;Coupled;dentate gyrus;design;Deterioration;Development;Developmental Delay Disorders;developmental genetics;digital;Disease;Disease remission;Dissociation;DNA Sequence Alteration;Dopamine;dopaminergic neuron;Down-Regulation;drug discovery;Electroencephalography;Emotional;emotional functioning;Encephalopathies;Epilepsy;epileptic encephalopathies;ergonomics;Exhibits;exome sequencing;experience;experimental study;feeding;Foundations;Frequencies;Functional disorder;Genes;Genetic;genetic approach;Genome;Growth;Hippocampus;Home;Human;Hyperactivity;Image;Impairment;improved;In Situ;innovation;insight;instrument;instrumentation;Intellectual functioning disability;Knockout Mice;Learning;Lesion;Life;Link;Measurement;Measures;Mediating;Mediator;Memory;Midbrain structure;Modeling;Molecular;Monitor;Motor;motor deficit;mouse model;multimodality;Mus;mutant;Mutant Strains Mice;neurobehavioral;neuropsychiatric disorder;neuropsychiatry;novel;Pathway interactions;Patient Care;Patients;Periodicity;Personal Satisfaction;pharmacologic;Phenotype;Physiological;Play;pre-clinical;Precision therapeutics;Process;Proteomics;Recurrence;response;Rest;Risk;Rodent;Role;Seizures;sensory integration;Shapes;Sleep;Sleeplessness;social reciprocity;Spontaneous Remission;Symptoms;Syndrome;synergism;Tamoxifen;Telemetry;Testing;Therapeutic;transcription factor;translational therapeutics;Up-Regulation;Variant;Visualization;Voltage-Gated Potassium Channel;wearable device;wireless;Work

PROJECT_TITLE: Dissecting the Developmental and Epileptic Components of Encephalopathy in DEE

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CN-E(02)M]


ORG_DEPT: PSYCHIATRY

PI_NAMEs: MCRAE-CLARK, AIMEE L (contact)

PROJECT_TERMS: Acceleration;Active Learning;Award;Biomedical Research;career;career development;Clinical Research;Collaborations;Development Plans;Environment;Extramural Activities;Faculty;Funding;Grant;Growth;Immersion;Individual;innovation;Institution;interdisciplinary collaboration;member;Mentors;novel;Positioning Attribute;Principal Investigator;Problem Solving;Productivity;programs;recruit;Request for Applications;Research;Research Methodology;Research Personnel;Science;skills;South Carolina;success;Training;Translational Research;United States National Institutes of Health

PROJECT_TITLE: Institutional Career Development Core


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE  This project can promote our fundamental understanding of two important biological processes: 1) the regulation of host autophagy, which plays a crucial role in the degradation of protein aggregates, dysfunctional organelles, and bacteria; and 2) the pathogenesis mechanisms utilized by intracellular bacteria such as Legionella pneumophila. Given the implication of autophagy in neurodegenerative and immune-related diseases and the strategies used by various intracellular bacteria to cause infection, increasing our knowledge in these topics can lead to the development of novel treatments for a wide range of diseases.

PI_NAMEs: PARDUCHO, KEVIN REYES (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TITLE: The Anti-Autophagy Arsenal of Legionella pneumophila


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Brain Disorders;Neurosciences

ORG_CITY: SANTA CRUZ

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: Project Narrative Brain aging poses a significant challenge to the modern society. Infusion of aged blood into young animals decreases neurogenesis and impairs cognition, which suggests the existence of age-elevated systemic factors detrimental to brain health. We propose to identify systematic pro-aging factors in the blood, to investigate the mechanism underlying their damaging effects on neuronal synapses, and to search for means to restore the expression pattern of such factors to the healthy young state in order to rescue synaptic defects and improve cognitive functions.

PI_NAMEs: CONBOY, IRINA M;MOURRAIN, PHILIPPE ;ZUO, YI  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Affect;Age;age related;aged;Aging;aging brain;aging related;Amino Acids;Animals;Anti-Inflammatory Agents;Array tomography;Behavior;Blood;Blood - brain barrier anatomy;Brain;brain cell;brain health;Brain imaging;Cells;Central Nervous System;Chronic;Cognition;cognitive function;cytokine;Data;Defect;Dendritic Spines;Disease;Dissection;Drug or chemical Tissue Distribution;Excitatory Synapse;Exhibits;experimental study;frontal lobe;functional decline;Health;hippocampal pyramidal neuron;Hippocampus;Homeostasis;Human;IL17 gene;Image;imaging modality;Imaging Techniques;Immune;Immune response;Impaired cognition;Impairment;improved;in vivo;in vivo two-photon imaging;Individual;Inflammaging;Inflammation;Inflammatory;Inflammatory Response;Infusion procedures;inhibitor;Interleukin-1 beta;Interleukin-10;Interleukin-13;Interleukin-4;Interleukin-6;juvenile animal;Life Expectancy;Literature;Living Standards;Mediating;Mediator;Microglia;Modern Medicine;Modernization;Molecular;Molecular Profiling;Morphology;Motility;Mus;Nerve Degeneration;nervous system development;neural circuit;Neurodevelopmental Disorder;neurogenesis;Neuroimmune;neuroinflammation;Neurons;normal aging;old mice;Oxytocin;Parabiosis;Pattern;Peptides;Peripheral;Pharmaceutical Preparations;Physiological;Population;postsynaptic;potential biomarker;prevent;pro-aging;Process;protein expression;Proteins;Proteome;Proteomics;Publishing;reconstruction;Rejuvenation;Research;response;Signal Pathway;Signal Transduction;Site;Societies;Somatosensory Cortex;Structure;Surgical sutures;Synapses;Testing;Therapeutic Effect;therapeutic evaluation;tissue repair;Tissues;TNF gene;Transforming Growth Factor beta;two photon microscopy;ultra high resolution;Vertebral column;Work

PROJECT_TITLE: Identifying signatures of brain aging through heterochronic blood exchange


NIH_SPENDING_CATS: Diabetes;Genetics;Regenerative Medicine;Wound Healing and Care

ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE  Non-healing diabetic wounds are the most common cause of amputation in the United States with a 5- year mortality of nearly 50% and annual cost to the healthcare system of $19 billion. Our preliminary data demonstrate that epigenetic changes in diabetic keratinocytes, driven by JAK/STAT/SETDB2, regulate the activity of inflammatory cytokine production (i.e., TNFα). Increased production of TNFα by diabetic keratinocytes then functions to impair keratinocyte migration and further promotes inflammation by promoting a pro- inflammatory macrophage phenotype. The success of the human and animal studies outlined in this proposal may lead to improved understanding of the pathophysiology of non-healing diabetic wounds and test novel therapeutic targets and allow me to develop as a translational scientist.

PI_NAMEs: MOON, JADIE  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Amputation;Animals;Blood specimen;Cell Physiology;Cells;Chromatin;Complex;cost;cytokine;Data;Death Rate;Defect;Development;diabetic;Diabetic mouse;diabetic ulcer;diabetic wound healing;diet-induced obesity;dietary;Enzymes;Epigenetic Process;epigenetic regulation;experimental study;Failure;Functional disorder;Gene Expression;Genes;Genetic;Genetic Transcription;healing;Healthcare Systems;Histone H3;histone methylation;histone methyltransferase;Human;human RNA sequencing;IL17 gene;Immune;Immunologist;Impaired wound healing;Impairment;improved;in vivo;Inflammation;Inflammatory;Interferon-beta;Janus kinase;keratinocyte;Link;Lysine;Macrophage;Mediating;Mediator;migration;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;new therapeutic target;NF-kappa B;non-healing wounds;Non-Insulin-Dependent Diabetes Mellitus;novel;Pathologic;Pathway interactions;Patients;pharmacologic;Phenotype;Play;prevent;Process;Production;re-epithelialization;Regulation;Repression;Research Design;Resolution;Role;Signal Transduction;single-cell RNA sequencing;skills;Skin;Skin repair;STAT protein;STAT1 gene;Stat3 protein;success;targeted treatment;Techniques;Testing;Therapeutic Agents;therapeutic target;tissue repair;Tissue Sample;TNF gene;translational approach;translational scientist;Treatment Efficacy;United States;Up-Regulation;wound;wound care;wound healing;Wound models

PROJECT_TITLE: Epigenetic regulation of keratinocyte function in normal and pathologic skin repair


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Immunotherapy;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE This project will inform on the potential for using the immune checkpoint molecule, B7-H3, as a novel therapy for medulloblastoma, the most common malignant pediatric brain tumor. This will be accomplished by comprehensively evaluating its efficacy as a direct anti-tumor agent and as a modulator of the tumor immune microenvironment. This project will assess the ability of B7-H3 to penetrate the blood brain barrier and extend the survival of tumor-bearing mice while monitoring for any central nervous system toxicity.

PI_NAMEs: MARTIN, ALLISON M. (contact)

PROJECT_TERMS: Address;Animal Model;anti-tumor agent;anti-tumor immune response;Antibodies;Bioinformatics;Biostatistical Methods;Blocking Antibodies;blood-brain barrier crossing;blood-brain barrier penetration;Bone Marrow;c-myc Genes;cancer therapy;career development;CD276 gene;Cell Cycle;Cell Death Induction;Cells;Central Nervous System;Cephalic;Characteristics;checkpoint therapy;Child;Childhood;Childhood Brain Neoplasm;Childhood Malignant Brain Tumor;Clinical;Clinical Trials;college;Color;Contralateral;CRISPR/Cas technology;cytokine;Data;design;Detection;Disease;Doctor of Philosophy;efficacy evaluation;Enzyme-Linked Immunosorbent Assay;Face;Family;Flow Cytometry;Foundations;Future;Generations;genome editing;Genomics;Growth;Histology;Human;Immune;immune cell infiltrate;immune checkpoint;Immune checkpoint inhibitor;Immune mediated destruction;Immune system;Immunocompetent;Immunohistochemistry;Immunologist;Immunology;immunoregulation;Implant;improved;In Vitro;in vivo;Inflammatory;interest;knock-down;Knockout Mice;Knowledge;Learning;Literature;Malignant Childhood Neoplasm;Malignant neoplasm of brain;Medical center;Medicine;Medulloblastoma;medulloblastoma cell line;Mentors;Modeling;Molecular;Monitor;Monoclonal Antibodies;mouse model;Mus;Mutate;Neurosciences;new therapeutic target;novel;novel therapeutics;Oncogenes;Oncologist;overexpression;Pathogenesis;Pathway interactions;Patients;Pediatric Neoplasm;Pediatric Oncology;permissiveness;Phase I Clinical Trials;Phenotype;Physicians;Population;pre-clinical;preclinical evaluation;Production;Prognosis;Program Development;programmed cell death ligand 1;programs;Proliferating;Publishing;Recurrent disease;Refractory;Relapse;Reporting;Research;Risk;Sampling;Scientist;single cell analysis;single-cell RNA sequencing;skills;Sorting;standard care;stem;Subgroup;success;Survivors;Techniques;Testing;Therapeutic;therapeutic target;Therapy Evaluation;Tissue Microarray;tool;Toxic effect;TP53 gene;Treatment Efficacy;tumor;Tumor Tissue;tumor-immune system interactions;Universities;Wild Type Mouse;Work

PROJECT_TITLE: B7-H3 in Medulloblastoma: evaluating its expression and function to harness new therapeutic targets


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Cannabidiol Research;Cannabinoid Research;Complementary and Integrative Health;Natural Products;Therapeutic Cannabinoid Research

ORG_DEPT: ZOOLOGY

PHR: Project Narrative Plant meroterpenoids are a large and diverse class of molecules producing by flowering plants, fungi, and liverworts. While the cannabinoids, from Cannabis sativa, have held the focus of the scientific community for the decades since they were discovered, alternative scaffolds from other producers studied to-date have unique pharmacology, suggesting they are interesting targets for therapeutic development. In this proposal, I describe my plan to repurpose biosynthetic pathway enzymes to chemoenzymatically produce new designer plant-like meroterpenoids, discover new enzyme cyclases capable of generating scaffolds with unique stereoselectivity and large steric modifications, and evaluate the potential of these new molecules as therapeutics through GPCR pharmacology.

PI_NAMEs: LOVE, ANNA CLAIRE (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TITLE: Chemoenzymatic synthesis and pharmacological evaluation of designer plant meroterpenoids


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Diabetes;Neurosciences

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: Project Narrative Brain glucose sensing plays a critical role in maintaining the blood glucose balance, but the underlying mechanisms remain to be fully understood. Here we will delineate the mechanisms by which a novel neural population in the brain can rapidly sense a glucose fall (hypoglycemia) and then prevent severe hypoglycemia. This study may provide a framework for the development of novel strategies to treat or prevent severe hypoglycemia.

PI_NAMEs: HE, YANLIN  (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Address;Amygdaloid structure;Animals;Blood Glucose;blood glucose regulation;Brain;Calcium;Calcium Channel;Closure by clamp;Clustered Regularly Interspaced Short Palindromic Repeats;counterregulation;CRISPR/Cas technology;Data;Development;diabetic;diabetic patient;DNA;Electrophysiology (science);Equilibrium;ESR1 gene;Event;Failure;falls;Fiber;gamma-Aminobutyric Acid;Genes;Genetic;Glucose;Glutamates;glycemic control;Hormones;Hyperinsulinism;Hypoglycemia;Hypothalamic structure;Impairment;in vivo;Ion Channel;Lateral;Life;Maps;Medial;Mediating;Mediator;Modeling;Molecular;Molecular Target;Monitor;Mus;Nature;neural;neural circuit;neural network;Neuroanatomy;neurochemistry;Neurons;novel;novel strategies;novel therapeutic intervention;optogenetics;patch sequencing;Photometry;Physiological;Play;Population;prevent;Property;Reporting;response;Role;SF1;Slice;Structure of nucleus infundibularis hypothalami;Structure of paraventricular nucleus of thalamus;Subgroup;Substantia nigra structure;Testing;type I diabetic;ventromedial hypothalamic nucleus;vesicular GABA transporter;voltage;Work

PROJECT_TITLE: GABA neurons in the ventromedial hypothalamus contribute to the counterregulatory response


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Relevance Medical imaging is one of the key methods used by cancer researchers to study human biology in health and disease. The imaging informatics platform described in this application will enable cancer researchers to capture, analyze, and share imaging and related data. These capabilities address key bottlenecks in the pathway to discovering cancer cures and treatments.

PI_NAMEs: MARCUS, DANIEL SCOTT (contact)

PROGRAM_OFFICER_NAME: KIM, BOKLYE

PROJECT_TERMS: Academia;Academy;Address;Administrator;Adopted;Adoption;Advanced Development;anti-cancer research;application programming interface;Area;Artificial Intelligence;artificial intelligence method;Automation;base;cancer imaging;Clinical;Clinical Data;clinical translation;Cloud Computing;Cloud Service;cohort;Communities;community engagement;computerized data processing;computing resources;Data;Data Aggregation;Data Analyses;Data Commons;data dissemination;data management;data platform;Data Scientist;Data Set;data sharing;Database Management Systems;deep learning;Development;Digital Imaging and Communications in Medicine;Disease;Ecosystem;Education;education resources;Educational Curriculum;Educational workshop;Engineering;Ensure;Environment;Event;FAIR principles;feature extraction;Funding;Grant;Health;High Performance Computing;Human Biology;Image;Image Analysis;imaging informatics;improved;indexing;Industry;Informatics;informatics tool;Information Systems;International;Knowledge;Knowledge Management;large datasets;Lead;Malignant Neoplasms;Medical Imaging;Methods;Multi-Institutional Clinical Trial;National Cancer Institute;Natural Language Processing;NCI Center for Cancer Research;Online Systems;open source;outreach;Outreach Research;Pathway interactions;Patient Care;Patients;Persons;Phase;Play;preclinical imaging;Radiology Information Systems;reconstruction;Request for Applications;Research;Research Personnel;Resources;response;Role;Series;Services;sharing platform;Structure;success;symposium;System;Technology;The Cancer Imaging Archive;tool;Training Programs;trend;Visualization;web services;Work

PROJECT_TITLE: Sustaining the Integrative Imaging Informatics for Cancer Research (I3CR) Center