NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative In this application we are renewing our commitment to the ECHO ISPCTN by creating SPeCTRE 2.0 a Clinical Site for the network from the state of Kansas. Our main goal is to enhance the health of children by providing answers to relevant research questions regarding the health of children living in rural and underserved areas in Kansas. We are expanding on the previous success of our site by the addition of new sites, expanding our training capacity of researchers and adding more experienced NIH funded mentors to this application.

PI_NAMEs: DAVIS, ANN M (contact);JONES, BRIDGETTE L.

PROGRAM_OFFICER_NAME: RAJU, TONSE N

PROJECT_TERMS: Address;Advisory Committees;Affect;Area;Area Health Education Centers;Black Populations;Cancer Center;Child;Child Health;Childhood;Clinical and Translational Science Awards;clinical research site;Clinical Skills;clinical trial recruitment;Clinical Trials;Clinical Trials Network;Collaborations;Communities;Computerized Medical Record;Conduct Clinical Trials;Contracts;Death Rate;demographics;Development Plans;Disparity;Education;Educational Curriculum;Educational Status;Effectiveness;ethnic minority;Ethnic Origin;Ethnic Population;experience;Exposure to;Family;frontier;Funding;Future;Geography;Goals;Health;health care availability;Healthcare;Hispanic Populations;Immunization;implementation science;improved;Income;Infant Mortality;Infrastructure;Institution;Institutional Review Boards;Kansas;low socioeconomic status;Medical;Mentors;Multi-Institutional Clinical Trial;Not Hispanic or Latino;Obesity;Outcome;Outcome Measure;outreach;Patient Recruitments;Patients;pediatric patients;Pediatric Research;Performance;Policies;poor health outcome;Population;population health;Prevention Research;Productivity;programs;Provider;Quality of life;Race;racial minority;recruit;Registries;Reporting;Research;Research Personnel;Resources;Risk Behaviors;Rural;rural America;rural area;Rural Community;rural disparities;rural families;Rural Health;rural Hispanic;Site;skill acquisition;skills;social health determinants;Specialist;suburb;success;Sunflowers;telehealth;Telemedicine;Time;Training;underserved area;underserved community;United States National Institutes of Health;Universities;Vaccines;Variant;Work

PROJECT_TITLE: SPeCTRE 2.0: The Sunflower Pediatric Clinical Trials Research Extension


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: Princeton

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: A major drawback for progress in diagnosis and treatment is a lack of a mechanistic understanding of how symptoms develop and are grounded in fundamental brain processes. The present research aims to map global and visible clusters of psychiatric symptoms – internalizing vs. internalizing – to dysfunction in underlying neurocomputational processes that we can understand and measure. If successful, this could lead to better diagnostic tests, more individualized treatment, and new therapeutic approaches.

PI_NAMEs: DAW, NATHANIEL DOUGLASS (contact)

PROGRAM_OFFICER_NAME: FERRANTE, MICHELE

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;Aggressive behavior;Anxiety;Architecture;associated symptom;Behavior;Brain;Categories;Child;Childhood;Choice Behavior;Clinical;Clinical Data;comorbidity;Compulsive Behavior;computational neuroscience;Computer Models;Data;Decision Making;Development;Developmental Process;Diagnosis;Diagnostic;Diagnostic tests;Dimensions;Disease;Dissociation;Environment;experimental study;follow-up;Foundations;Functional disorder;General Population;Goals;improved;Impulsivity;Individual;individualized medicine;information gathering;insight;Learning;Legal patent;Maps;Measures;Mental Depression;Mental disorders;Mental Health;Methods;National Institute of Mental Health;neglect;neural;novel;novel therapeutic intervention;Participant;Patients;Pattern;Pharmacological Treatment;Population;population based;Process;Psyche structure;psychiatric symptom;Psychiatry;psychologic;Psychological reinforcement;Psychopathology;Race;Research;response;Rewards;rumination;Sampling;simulation;Sorting;Strategic Planning;symptom cluster;Symptoms;Taxonomy;Testing;theories;Update;Work

PROJECT_TITLE: CRCNS: Computational Foundations for Externalizing/Internalizing Psychopathology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-P(50)R]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PI_NAMEs: BIRKMEYER, NANCY J (contact)

PROJECT_TERMS: acute care;Address;Affect;aging in place;Alzheimer's disease related dementia;American;Awareness;care systems;Caregivers;Case Management;Characteristics;clinical care;Collaborations;Collection;Communities;community based service;Complex;cost;Data;design;Development;Diagnosis;Disparity;Emergency department visit;evidence base;explicit bias;Family;federal policy;Funding;General Population;Government Subsidy;Health;Health behavior;health care disparity;health care service utilization;Health Policy;Health Promotion;health service use;Health Status;Home;Home Nursing Care;Housing;Immunization;implicit bias;improved;Incentives;Independent Living;Inequality;informant;innovation;inpatient service;insight;Institutionalization;Interview;Link;Maintenance;Measures;Mediating;Mental Health;Methods;Modeling;Neighborhoods;older adult;Older Population;Outcome;Personal Satisfaction;Persons;Play;Policies;prevent;Preventive care;Primary Care;Privatization;pro-aging;Productivity;programs;Property;Quality of life;Reduce health disparities;Retrospective cohort study;Role;Sampling;service coordination;service utilization;Services;social;social determinants;social health determinants;Social support;Structure;Surveys;synergism;U.S. Department of Housing and Urban Development;United States;United States Centers for Medicare and Medicaid Services

PROJECT_TITLE: Resident Services Coordination to Support Aging in Place in Affordable Housing for Persons with Alzheimer's Disease and Related Dementias


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: PHILADELPHIA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Retinal diseases are one of the leading causes of blindness worldwide and there is currently no treatment to restore vision after photoreceptor cell death. I have discovered novel populations of photoreceptor precursor cells that contribute to normal retinal development and may restore visual function when transplanted or endogenously activated in mouse models of retinal degeneration. Understanding the potential of these cells to regenerate photoreceptors in late-stage retinal degenerations may lead to new potential therapies for blinding diseases.

PI_NAMEs: UYHAZI, KATHERINE E. (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Address;adenovirus mediated delivery;Age related macular degeneration;alternative treatment;Animals;behavior test;Blindness;career;Cell Cycle;Cell Death;Cell Therapy;Cell Transplantation;cell type;Cells;Chemicals;Childhood;Complementary DNA;Complex;Cues;Development;Disease;disease model;Dissociation;DNA Sequence Alteration;early onset;Electroretinography;Environment;Eye;FDA approved;Foundations;functional improvement;gene product;gene therapy;Genes;Genetic;GLAST Protein;Heterogeneity;Histology;Human;human disease;Image;Immunofluorescence Immunologic;improved;in vivo;in vivo regeneration;inherited retinal degeneration;Injury;Label;Lead;Leber's amaurosis;Leber's disease;Mediating;Mendelian disorder;Mentorship;Modeling;Molecular;mouse model;Muller's cell;Mus;Mutation;Natural regeneration;neonatal mice;Neuroglia;novel;Ophthalmology;Optical Coherence Tomography;Papain;Pathway interactions;Patients;Pennsylvania;Photoreceptors;Physicians;Population;postnatal;precursor cell;Predisposition;preservation;progenitor;pup;regenerative;Regenerative capacity;repaired;Reporter;Reporting;Research;Resources;Retina;Retinal Degeneration;Retinal Diseases;retinal neuron;retinal progenitor cell;retinal regeneration;retinal stimulation;retinogenesis;RNA;RPE65 protein;Safety;Scientist;Severities;sight restoration;single-cell RNA sequencing;skills;Sorting;Stem cell pluripotency;Stem cell transplant;stem cells;Structure;Testing;Therapeutic;Time;Training;transcription factor;transcriptomics;Transplantation;Universities;vector;viral gene delivery;Vision;Zebrafish

PROJECT_TITLE: Photoreceptor Regeneration in a Murine Model of Leber Congenital Amaurosis


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Hearing Loss;Neurosciences

ORG_CITY: INDIANAPOLIS

ORG_DEPT: BIOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Hearing depends on the formation and maintenance of functional stereocilia, which are highly structured protrusions on the surface of sensory cells in the inner ear. Stereocilia cores are formed by bundles of the cytoskeletal protein actin, which determine the shape and stability of stereocilia. We propose to investigate a newly-identified population of short actin filaments at stereocilia tips that likely contribute to stereocilia development and maintenance.

PI_NAMEs: PERRIN, BENJAMIN J (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TITLE: Cytoskeletal stability in stereocilia maintenance

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: BURLINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: Genome instability, which is associated with multiple human diseases, is a byproduct of mutations that accumulate in the human genome as a result of the error prone DNA copying translesion synthesis (TLS) enzymes. Recent publications and strong preliminary work from my lab have shown that the TLS REV1 polymerase regulates metabolic pathways, mitotic fidelity, and replication stress, all of which are known to be associated with genome instability. This proposal will determine the molecular mechanisms by which REV1 controls these non-TLS functions and their potential roles in genome instability.

PI_NAMEs: CHATTERJEE, NIMRAT  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Autophagocytosis;Biological;Black Box;Bypass;Cell Death;Cell Physiology;Communicable Diseases;Data;Dimensions;Disease Progression;disorder control;DNA;DNA biosynthesis;DNA Damage;DNA Sequence Alteration;Enzymes;Exercise;Genome Components;Genomic Instability;Goals;human disease;Human Genome;insight;Laboratories;Malignant Neoplasms;Metabolic;Metabolic Pathway;Metabolism;Mitosis;Mitotic;Modeling;Modification;Molecular;Mutagenesis;Mutation;Neurodegenerative Disorders;novel;novel therapeutics;Onset of illness;Other Genetics;Pathway interactions;Polymerase;Process;Proteins;Publications;replication stress;response;Role;senescence;tool;Translating;Work

PROJECT_TITLE: Mechanistic insights into translesion synthesis-dependent genome instability

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Primary Health Care;Social Determinants of Health

PI_NAMEs: FISHER, ELLIOTT S (contact)

PROJECT_TERMS: access disparities;Address;Adoption;Affect;Algorithms;Alzheimer's disease patient;Alzheimer's disease related dementia;beneficiary;care delivery;care outcomes;Caring;Case Study;Chronic;Clinical;cohort;Collaborations;Communities;community based service;Complex;COVID-19;COVID-19 pandemic;Cross-Sectional Studies;Data;data resource;Data Set;Diagnosis;Disparity;disparity reduction;Economics;falls;federal policy;Foundations;Funding;gaps in access;Goals;health care disparity;health care service;health care service organization;Health Services Accessibility;Health system;Home;improved;Interview;Investigation;Link;Managed Care;Measures;Medicare;Medicare claim;Methods;Minority Groups;older adult;Outcome;Ownership;Patient Care;Patients;Persons;Physicians;Play;Policies;Policy Maker;Population;practice factors;Prevalence;Prevention;Primary Care;primary care clinician;primary care patient;primary care practice;primary care services;Process;Program Research Project Grants;Quality of Care;Race;Recommendation;Research Project Grants;residential segregation;Resources;Respondent;Retirement;Risk;Role;Sampling;Services;Site;social;socioeconomics;Source;Surveys;synergism;System;Testing;Time;trend;United States;United States Agency for Healthcare Research and Quality;Update;Variant;Wood material;Work

PROJECT_TITLE: High-Quality Primary Care for Older Adults with Alzheimer's Disease and Related Dementias: A National Mixed Methods Study


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Clinical Research;Dementia;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Heart Disease - Coronary Heart Disease;Lung;Neurodegenerative;Neurosciences;Patient Safety

PI_NAMEs: AGHA, LEILA S. (contact)

PROJECT_TERMS: Accident and Emergency department;Accounting;Accreditation;Acute;acute care;Acute Disease;Acute myocardial infarction;Affect;Alzheimer's disease diagnosis;Alzheimer's disease patient;Alzheimer's disease related dementia;Ambulances;American;Benefits and Risks;Caregivers;Caring;Clinical;clinical decision-making;cognitive testing;Collaborations;Communication;Communication difficulty;community based service;Data;Death Rate;Diagnosis;Diagnostic;Diagnostic tests;Discrimination;Disease Management;disorder risk;Emergency Care;Emergency department visit;Equity;Event;Goals;Health;health care disparity;high risk;Home;Home Nursing Care;Hospitalization;Hospitals;Impaired cognition;improved;improved outcome;Joints;lens;Link;machine learning prediction;Measures;Medicare claim;Methods;Minority Groups;Modeling;mortality;mortality risk;Nursing Homes;Outcome;Ownership;Pathway interactions;patient population;Patient Preferences;Patient risk;Patient-Focused Outcomes;Patients;Pattern;Performance;poor health outcome;predictive modeling;predictive test;Primary Care;Procedures;Process;Provider;Pulmonary Embolism;Quality of Care;Recording of previous events;Recovery;Resources;Respondent;Retirement;Risk;Risk Factors;Scanning;Severities;shared decision making;Surveys;Symptoms;synergism;Testing;treatment strategy;Uncertainty;Variant;Work;X-Ray Computed Tomography

PROJECT_TITLE: Improving Acute Disease Management for Patients with Alzheimer's Disease and Related Dementias


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Burden of Illness;Clinical Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Rare Diseases;Social Determinants of Health;Valley Fever

ORG_CITY: ANN ARBOR

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The incidence of coccidioidomycosis in California has doubled since 2014; yet the true burden is not well understood and there are no approved tests for measuring prevalence of prior infection among the general population. This project develops new computational and statistical frameworks to estimate population immunity, identify disparities in disease burden and under-reporting, and understand the role of population immunity in disease transmission and emergence. The findings will have wide-ranging benefits for public health, including a better understanding of coccidioidomycosis under-reporting among vulnerable sub- populations, an ability to target resources more effectively, and support for unbiased estimation of risk factors for infection.

PI_NAMEs: HEAD, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Acceleration;Accounting;Age;age related;Area;Awareness;Bayesian Modeling;Biology;Biometry;Black Populations;Body part;burden of illness;California;career;career development;Career Mobility;Case Study;cell mediated immune response;Censuses;Cessation of life;Chronic;climate change;Coccidioides;Coccidioidomycosis;Communicable Diseases;Communities;community acquired pneumonia;Computational Technique;Computing Methodologies;County;Data;data integration;Death Rate;Decision Making;Demography;Detection;Development;Diagnostic;diagnostic tool;disability-adjusted life years;Disease;disease transmission;Disparity;Droughts;Emerging Communicable Diseases;Environment;Environmental Health;Epidemiologist;Epidemiology;Ethnic Origin;Ethnic Population;Exhibits;experience;faculty mentor;FDA approved;Future;General Population;Geographic Locations;Geography;Goals;Grant;Head;health care availability;health care disparity;health care service utilization;Health system;Hispanic Populations;Humoral Immunities;Hypersensitivity skin testing;Immune;Immunity;Immunize;Immunologics;Immunology;Incidence;Individual;Infection;infection risk;Infectious Disease Epidemiology;Inhalation;Knowledge;large datasets;Leadership;Link;Location;Mathematics;Measures;Meningitis;Mentored Research Scientist Development Award;Mentors;Mentorship;Methods;Military Personnel;Modeling;Movement;multiple data sources;Mycoses;neglect;Occupational;Patients;Pattern;Persons;Physicians;Population;Predisposition;Prevalence;Probability;Public Health;Publishing;Race;racial population;Recording of previous events;Recreation;recruit;Reporting;Reproduction spores;Research;Research Activity;Research Project Grants;Resource Allocation;Resources;Respiratory Disease;Respiratory Tract Infections;Risk;Risk Estimate;Risk Factors;Role;Scientist;Screening procedure;Series;Seroprevalences;serosurvey;Severities;skills;social epidemiology;social factors;Soil;Source;Subgroup;surveillance data;Surveys;Symptoms;System;Testing;Time;Training;transmission process;Universities;vaccination strategy;Work;Writing

PROJECT_TITLE: Modelled estimation of population immunity for coccidioidomycosis and the role of immunologically naïve populations in the shifting epidemiology of coccidioidomycosis in California

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Health Services;Lung;Lung Cancer;Prevention

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

ORG_STATE: CA

PHR: Project Narrative Nikki Carroll, MS, supports the Cancer and Genomics Research Core at the Kaiser Permanente Colorado Institute for Health Research. Her work has made significant contributions to translational research in cancer treatment patterns and outcomes that occur in real world clinical settings (as opposed to clinical trial settings). Support from this award will allow her to continue her focus in cancer research with an emphasis on treatment and risk of recurrence in the context of screen-detected cancers.

PI_NAMEs: CARROLL, NIKKI  (contact)

PROGRAM_OFFICER_NAME: MARCUS, PAMELA M

PROJECT_TERMS: anti-cancer research;Award;cancer care;Cancer Detection;cancer diagnosis;Cancer Patient;cancer therapy;career;Clinical;Clinical Trials;Colorado;community setting;Doctor of Philosophy;Foundations;Funding;Future;Genomics;Goals;Health;Health system;individualized medicine;Journals;lung cancer screening;Malignant neoplasm of lung;Malignant Neoplasms;Manuscripts;meetings;Natural History;Peer Review;Productivity;prognostic;Recurrence;Regimen;Research;Risk;screening;Specialist;Time;Translational Research;treatment choice;Treatment outcome;treatment pattern;treatment risk;Treatment-Related Cancer;Work

PROJECT_TITLE: Natural History of Lung Cancer Diagnosed Within and Across Diverse Health Systems Implementing Lung Cancer Screening


ADMINISTERING_IC: NS

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE  The ability to flexibly prioritize stimuli based on their ongoing behavioral relevance is critical for thriving in a complex environment. Behavioral flexibility is commonly affected in many neurodevelopmental conditions including attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorders, but the cell type-specific neural circuits underlying these processes are not well understood. The proposed project will use modern genetic tools in mice to mechanistically test the role of local interneurons and long-range cholinergic inputs in gating flexible modulation of sensory cortex and behavior in response to the history of stimuli, actions and rewards experienced in the recent past.

PI_NAMEs: RAMAMURTHY, DEEPA L (contact)

PROGRAM_OFFICER_NAME: JOHNSON, KARI ANNE

PROJECT_TERMS: Acetylcholine;Affect;Animals;Area;Arousal;Attention;Attention deficit hyperactivity disorder;attentional bias;autism spectrum disorder;Axon;basal forebrain;Behavior;behavior influence;behavior prediction;Behavioral;behavioral impairment;Behavioral Model;Behavioral Paradigm;Behavioral trial;Calcium;cell type;Cells;cholinergic;Code;Complex;Cues;Data;Detection;detection sensitivity;Disinhibition;Environment;Exhibits;expectation;experience;experimental study;flexibility;Future;Genetic;Glutamates;Goals;Human;Image;Individual;insight;Interneurons;Learning;Logistic Regressions;Maps;Mediating;Modeling;Modernization;Monitor;Mus;neural;neural circuit;Neuromodulator;neuroregulation;novel;optogenetics;Perception;Performance;Phase;Play;Primates;Process;Pyramidal Cells;Recording of previous events;recruit;response;Rewards;Rodent;Role;Sensory;sensory cortex;sensory gating;sensory input;sensory mechanism;sensory stimulus;Shapes;Signal Pathway;Signal Transduction;Somatosensory Cortex;Stimulus;Techniques;Testing;theories;tool;Touch sensation;two-photon;Vibrissae

PROJECT_TITLE: Cell type-specific mechanisms of history-dependent perceptual biases in sensory cortex


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Our long-term goal is to employ innovative community based participatory research principles to establish a community advisory board, to collaborate with our community partners to recruit, enroll, and retain a cohort of Black participants and, then, to examine causal mechanisms that increase the risk of preclinical and symptomatic Alzheimer disease (AD) within our cohort. Despite the growing older adult population and epidemiological studies suggesting that Blacks are at twice the risk of developing AD compared to Whites, and Blacks are severely underrepresented in AD research. This study aims to create a representative sample of Black participants and examine how risk factors of AD such as depression, stress, and social determinants of health impact cognitive functioning and preclinical AD.

PI_NAMEs: BABULAL, GANESH M (contact);HUDSON, DARRELL LEE

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: Adult;Affect;Aging;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid Proteins;Awareness;Behavioral;Biological;Biological Markers;Biological Models;Biostatistical Methods;Black American;Black Populations;Black race;Blood;brain health;Cerebrospinal Fluid;Chronic stress;Clinical;Cognition;Cognitive;cognitive function;cognitive testing;cohort;Collaborations;Communities;community advisory board;community based participatory research;community partners;Complex;Coping Behavior;Data;Dementia;dementia risk;depressive symptoms;Detection;Development;Diagnosis;Discrimination;dynamic system;Economics;Education;Educational workshop;Employment;Enrollment;Environmental Risk Factor;epidemiology study;Exposure to;follow-up;Genetic;Genomics;Goals;Health;health care availability;health care service utilization;Health Disparities Research;health equity;healthy aging;Heterogeneity;high risk;Hippocampus;human old age (65+);Image;Impaired cognition;indexing;Inflammation;Inflammatory;inflammatory marker;innovation;Intervention;Knowledge;Life Cycle Stages;Life Style;Link;longitudinal, prospective study;Magnetic Resonance Imaging;Maps;Measures;Mediator;Mental Depression;Methods;Modeling;Molecular;MRI Scans;multidisciplinary;National Institute on Aging;Neighborhoods;Nerve Degeneration;neuroimaging;Neurologic;Neuropsychological Tests;Neuropsychology;novel;older adult;Participant;participant retention;Plasma;Population;Population Heterogeneity;Population Study;pre-clinical;Prevalence;psychosocial;Recording of previous events;recruit;Research;Research Methodology;Resources;Risk;Risk Factors;Sample Size;Sampling;screening;social;social culture;social determinants;social factors;social health determinants;Socioeconomic Status;socioeconomics;Stress;suburb;Symptoms;tau Proteins;Testing;theories;trustworthiness;United States;Validation;Vascular Diseases;White Matter Hyperintensity;Work

PROJECT_TITLE: Aging Research Characterizing Health Equity via Social determinants (ARCHES)

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Precision Medicine;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE This research is relevant to public health because it will: 1) Improve risk prediction for patients with coronary artery disease (CAD), helping providers and patients make better decisions to prevent cardiovascular events, and 2) Identify molecular pathways of resilience to CAD, thereby halting or reversing its progression. By improving prevention and characterizing novel pathways of resilience, this proposal targets the NHLBI strategic focus areas of “(2) Enhancing resilience” and “(3) Preventing cardiovascular disease across the lifespan.”

PI_NAMEs: NEWMAN, JONATHAN D (contact);RUGGLES, KELLY VALENTINE

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: Acceleration;adipokines;adjudication;Algorithms;American;Apoptosis;Area;Biological;Biological Markers;biomarker identification;biomarker performance;candidate marker;candidate validation;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Caring;Cessation of life;Chronic;Clinical;clinical risk;cohort;Cohort Studies;Collaborations;Coronary Angiography;Coronary Arteriosclerosis;Data;Development;differential expression;Disease;disorder risk;Event;fatty acid metabolism;fatty acid oxidation;Fatty Acids;Future;GDF15 gene;Genes;Genetic;Goals;Heterogeneity;high risk;improved;improved outcome;Inflammation;Inflammatory;Injury;innovation;Interferons;Ischemia;Knowledge;life span;Lipolysis;Modeling;Molecular;molecular modeling;Molecular Target;multiple omics;Muscle Cells;Myocardial Infarction;National Heart, Lung, and Blood Institute;novel;novel marker;Outcome;Participant;Pathway interactions;patient population;Patients;Performance;personalized risk prediction;Phenotype;polygenic risk score;Population;predictive modeling;prevent;Prevention;pro-brain natriuretic peptide (1-76);Probability;programs;promote resilience;protective factors;Provider;Public Health;Quality of life;Research;research clinical testing;Residual state;resilience;resilience factor;Risk;Risk Assessment;Risk Factors;risk prediction;risk stratification;Severities;Severity of illness;Signal Pathway;Signal Transduction;Testing;Time;Trans-Omics for Precision Medicine;Transcript;transcriptome;transcriptomics;Troponin;Validation

PROJECT_TITLE: Molecular predictors of cardiovascular events and resilience in chronic coronary artery disease

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: PITTSBURGH

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it investigates the role of a new pathway in intervertebral disc degeneration and low back pain. The proposed studies aim to confirm the important roles of lactate as an important source for disc nutrition and gene regulation. If confirmed, it will provide a new research direction to identify novel therapeutic targets for this common and costly condition.

PI_NAMEs: SOWA, GWENDOLYN A;VO, NAM V (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Acetylation;Aerobic;Age;age related;age related changes;anaerobic glycolysis;Back Pain;Bioenergetics;Bioinformatics;Biological Assay;Carbon;Cell Culture Techniques;Cell Physiology;Cell Separation;Cell Survival;Cells;Chemicals;Chromatin;chromatin immunoprecipitation;Chromatin Structure;chronic back pain;cost;Data;deep sequencing;Degenerative Disorder;Development;Diffusion;disability;Disease;DNA;Economic Burden;Environment;Enzyme Inhibitor Drugs;Enzymes;Epigenetic Process;extracellular;Female;Foundations;Future;Gene Expression;Gene Expression Regulation;Genes;Genetic;Glucose;Glycolysis;Histones;Homeostasis;Human;Hypoxia;Injections;innovation;Interruption;Intervertebral disc structure;intervertebral disk degeneration;Knock-out;Lactic acid;Link;Low Back Pain;Lysine;Macrophage;male;Measures;Metabolic;Metabolism;Modeling;Molecular;mouse model;Mus;new therapeutic target;novel;nucleus pulposus;Nutrient;nutrition;Organ;Oxidative Phosphorylation;Oxygen;Pathway interactions;Pattern;Peripheral;Phenotype;Post-Translational Protein Processing;prevent;Public Health;Rattus;regenerative;Reporting;Research;Role;socioeconomics;Source;Spinal Diseases;success;Symbiosis;Tamoxifen;Testing;therapeutic target;tissue culture;Tissues;Transcriptional Regulation;transcriptome sequencing;Transgenic Mice;uptake;Vertebral column;Waste Products;wasting

PROJECT_TITLE: Metabolic Symbiosis: Lactate as an Epigenetic Regulator and a Biofuel in Age-dependent Intervertebral Disc Degeneration

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Type I Interferon induces expression of hundreds of genes to protect against viral infection. How these genes are regulated in different contexts, and how they work together to restrict viruses is not well understood. This project will apply novel technologies to define the mechanisms that regulate the type I Interferon response and the effectors that provide broad antiviral protection.

PI_NAMEs: BOGUNOVIC, DUSAN ;ROSENBERG, BRAD  (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Address;airway epithelium;Anti-viral Agents;antiviral drug development;antiviral immunity;Biological Assay;cell type;Cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;combinatorial;Communicable Diseases;Communication;Complex;COVID-19 outbreak;Cytometry;Data;DNA Viruses;Epithelial Cells;experimental study;Feedback;Fibroblasts;Gene Expression Profile;gene function;gene network;Genes;Growth;Herpesvirus 1;high dimensionality;Host Defense;Human;human model;Immune;imprint;in vitro Model;in vivo;Individual;Infection;Influenza A virus;Inherited;Interferon Inducers;Interferon Type I;Interferons;ISG15 gene;JAK1 gene;Journals;Laboratories;Mediating;Mediator;Memory;Nature;new technology;next generation;novel;pathogenic virus;Pathogenicity;Peripheral Blood Mononuclear Cell;Phenotype;Physiological;Predisposition;programs;Proteins;Refractory;Regulation;Resistance;Resolution;respiratory pathogen;response;RNA Viruses;Sampling;Secondary to;side effect;Signal Transduction;single-cell RNA sequencing;Syndrome;System;Techniques;Technology;Testing;Therapeutic;Time;Toxic effect;USP18 deficiency;Vaccination;Vesicular stomatitis Indiana virus;Viral;Viral Genes;viral pandemic;Viral Physiology;Virus;Virus Diseases;Virus Replication;virus testing;Work;Yellow Fever;Zika Virus

PROJECT_TITLE: Next Generation Resolution of Antiviral Gene Networks

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Hematology;Hodgkin's Disease;Human Genome;Lymphatic Research;Lymphoma;Prevention;Rare Diseases

ORG_CITY: LYON

ORG_COUNTRY: FRANCE

ORG_FIPS: FR

ORG_NAME: INTERNATIONAL AGENCY FOR RES ON CANCER

PHR: NARRATIVE For nearly two decades, the International Lymphoma Epidemiology (InterLymph) Consortium, has systematically and successfully uncovered genetic and non-genetic lymphoma and MM risk factors. The proposed project addresses key questions resulting from these efforts, including identification of genetic variants involved in susceptibility to MM, HL, and NHL subtypes and understanding of genetic pleiotropy between these and their interaction with select environmental risk factors. To do so, we will actively leverage the collective intelligence and resources of the InterLymph researchers by constructing a user- friendly, accessible, centralized platform of genetic and environmental data across the international scientific community that will promote collaboration and new scientific discoveries.

PI_NAMEs: CLAY-GILMOUR, ALYSSA IONE;HJALGRIM, HENRIK ;MCKAY, JAMES DOWLING (contact);WANG, SOPHIA S.

PROGRAM_OFFICER_NAME: MECHANIC, LEAH E

PROJECT_TERMS: Address;Autoimmune Diseases;B Cell Proliferation;biobank;Biology;Chemicals;chemotherapy;Classification;Clinical;clinical practice;Collaborations;Communities;Computer Systems;Data;Data Analyses;Data Coordinating Center;data harmonization;data sharing;Developed Countries;Disease;Disease susceptibility;Division of Cancer Epidemiology and Genetics;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;epidemiologic data;Epidemiology;Etiology;European ancestry;Evaluation;Exposure to;Family;Fostering;gene environment interaction;Genetic;genetic risk factor;Genetic study;genetic variant;genome wide association study;Genotype;Hematopoietic Neoplasms;Hodgkin Disease;human old age (65+);Immune system;Infection;Infectious Agent;innovation;insight;Intelligence;International;International Aspects;Laws;Lymphoma;Lymphomagenesis;male;Malignant Neoplasms;Methods;Multiple Myeloma;National Security;non-genetic;Non-Hodgkin's Lymphoma;novel;Obesity;Patients;Peer Review;Performance;Pharmaceutical Preparations;pleiotropism;polygenic risk score;Predisposition;Prevention;Privatization;Publishing;Radiation;Radiation exposure;Recording of previous events;Research;Research Activity;Research Personnel;Resources;Risk;Risk Factors;risk prediction;Role;Sample Size;Series;sex;Statistical Methods;Susceptibility Gene;Testing;Therapeutic;United States National Institutes of Health;user-friendly;Validation;Variant;virtual

PROJECT_TITLE: InterLymph Consortium: interrogating pleiotropy and gene by environment interactions among hematopoietic malignancies.

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: TR

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: The process of developing new medical treatments, new tests to detect disease, and new medical devices requires researchers with a special set of skills. The purpose of this training program is to provide these special skills to a diverse group of early-career researchers so that they can be more effective scientists and have a positive impact on public health in any educational or industry setting they work.

PI_NAMEs: SPILSBURY, JAMES  (contact)

PROGRAM_OFFICER_NAME: CONROY, JENNIE LYNN

PROJECT_TERMS: Clinical Sciences;Ohio;Postdoctoral Fellow;Translational Research;Universities

PROJECT_TITLE: Clinical and Translational Science Collaborative of Northern Ohio, CTSA Postdoctoral T32 at Case Western Reserve University


NIH_SPENDING_CATS: Cancer;Genetics;Urologic Diseases

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

PHR: PROJECT NARRATIVE (RELEVANCE TO PUBLIC HEALTH)  Radical cystectomy is a morbid, expensive, and complicated procedure which requires urinary diversion, usually with a urostomy. Because the response rates to pre-surgical chemotherapy and other therapies is high, many patients achieve complete response and therefore may be cured without radical cystectomy. Our intention is to further develop UTeRD, a urine biopsy test, for the purpose of distinguishing responders and nonresponders so that responders can be accurately detected and be triaged into radical cystectomy avoidance algorithms.

PI_NAMEs: ABBOSH, PHILIP  (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, LOKESH

PROJECT_TERMS: Acceleration;Address;Adjuvant Chemotherapy;Adopted;Affect;Algorithms;Benchmarking;Biological Markers;Biopsy;cancer clinical trial;Cancer Patient;cancer therapy;CDK4 gene;Cells;chemoradiation;chemotherapy;Cisplatin;Clinical;Clinical Trials;clinically relevant;Clinics and Hospitals;cohort;Collection;Cryopreservation;deep sequencing;Development;DNA;DNA Sequence Alteration;Doxorubicin;experimental study;Fox Chase Cancer Center;Funding;Genes;Goals;Hour;Immunotherapy;improved;In complete remission;inhibitor;Institution;Intention;interest;Knowledge;Libraries;Life;Malignant neoplasm of urinary bladder;Medical Oncologist;Methodology;Methods;Methotrexate;mortality;Muscle;muscle invasive bladder cancer;Mutate;Mutation;Nature;Neoadjuvant Therapy;Neoplasm Metastasis;next generation sequencing;Nivolumab;Nucleic Acids;Operative Surgical Procedures;Organ;Outcome;Pathologic;Patients;performance tests;Point Mutation;Predictive Value;Preparation;preservation;Procedures;Process;prospective;Protocols documentation;Public Health;Publishing;Radiation;Radiation Oncologist;Radical Cystectomy;Recurrence;Research;Residual Cancers;Residual Neoplasm;Residual state;responders and non-responders;response;Sampling;Shipping;skills;Specimen;Staging;success;Temperature;Testing;Time;tool;Triage;tumor;Tumor Tissue;urinary;Urinary Diversion;Urine;Urologist;Urostomy;Validation;Vinblastine

PROJECT_TITLE: Optimization of urinary DNA deep sequencing tests to enhance clinical staging of bladder cancer patients


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Genetics

ORG_CITY: Los Angeles

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: RNA structures play critical roles in virtually every aspect of biology and are deeply involved in human diseases. However, direct determination of RNA 3D structures in living cells has not been possible. In this proposal, we develop a new set of chemical and computational tools for the analysis of RNA 3D structures and dynamics in any biological and clinical samples, enabling structure-guided RNA function studies and RNA- targeted therapies for human diseases.

PI_NAMEs: LU, ZHIPENG  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: 3-Dimensional;Benchmarking;Binding;Biological;Biology;Cells;Chemicals;Clinic;Clinical;Code;Complex;computerized tools;Coupled;crosslink;Crosslinker;Cryoelectron Microscopy;Crystallography;Development;Disease;Gene Expression;Genetic;Goals;Guide RNA;High-Throughput Nucleotide Sequencing;human disease;improved;In Vitro;in vivo;Instruction;Length;Life Cycle Stages;Ligation;mathematical theory;Measures;Mediating;Medicine;Methods;Modeling;Molecular;Molecular Conformation;Nucleotides;Oligonucleotides;Physiological;Play;programs;Proteins;Research;Resolution;RNA;RNA analysis;RNA Sequences;RNA Viruses;RNA-targeting therapy;Role;Sampling;Signal Transduction;small molecule;stem;Structure;targeted treatment;Technology;technology development;therapeutic development;Therapeutic Intervention;three dimensional structure;three-dimensional modeling;transcriptome;transmission process;viral RNA;virtual

PROJECT_TITLE: High Throughput Determination of RNA 3D Structures and Dynamics in Vivo

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Genetics;Human Genome;Microbiome

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative As residents of the human body and the biosphere, microbial communities perform essential metabolic processes for maintaining human health. At present we do not understand how the genomic structure of microbial communities, and the environment in which they reside, gives rise to their emergent metabolic processes. With to goal of ultimately designing and controlling communities of microbes to improve human health, this project aims to discover the principles governing how environmental variation impacts the metabolism of microbial collectives.

PI_NAMEs: KUEHN, SEPPE  (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TITLE: Environmental modulation of metabolic function in microbial communities


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Climate-Related Exposures and Conditions;Clinical Research;Mental Health;Neurosciences;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health

PHR: Project Narrative Starting in utero, key neurophenotypes are vulnerable to environmentally-induced programming that impact metabolic disease later in life. Findings may identify sex specific mechanisms that will increase our understanding of the mechanisms by which developmental origins of obesity operate and elucidate novel interventions to help those at heightened risk.

PI_NAMEs: WRIGHT, ROBERT O (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: 12 year old;16 year old;Address;Adolescence;Adolescent;adolescent health;Adolescent obesity;Adult;Affect;Affective Symptoms;Age;age related;Air Pollution;Anxiety;Behavior;biological adaptation to stress;Birth;Body mass index;Body System;boys;Brain;Calories;causal model;Cell Differentiation process;Chemicals;Child;Child Health;Childhood;Cities;cohort;comorbidity;Complex;Data;Data Collection;design;Development;diagnostic strategy;Disease;Dual-Energy X-Ray Absorptiometry;early childhood;Emotions;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Event;experience;Exposure to;fetal;fine particles;follow-up;Food;girls;Grant;Growth;Growth and Development function;Hair;Health;Hydrocortisone;Hyperphagia;in utero;Incidence;Individual;infancy;Inflammation;Inflammatory;Intervention;Knowledge;late life;Late-Onset Disorder;Learning Disabilities;Life;Life Cycle Stages;Link;Literature;Measures;Mediating;Mediation;Mediator;Mental Depression;Mental Health;Metabolic;Metabolic Diseases;Mexico;Modeling;Modernization;Mothers;Nature;negative affect;neurobehavior;neurobehavioral;neurodevelopment;neurotoxic;Neurotoxins;Nitrogen Dioxide;novel;Obesity;obesity in children;obesogenic;offspring;Overweight;Pathway interactions;perceived stress;Perinatal;perinatal environment;Perinatal Exposure;perinatal period;Phenotype;phenotypic data;Physiological Processes;Play;Predisposition;Pregnancy;Premature Infant;prenatal;Prevention;Procedures;programs;prospective;Psychological Stress;Psychosocial Stress;Research;Research Personnel;Research Project Summaries;Risk;Risk Factors;Role;Salivary;Scanning;School-Age Population;Self Concept;sex;sex as a biological variable;sexual dimorphism;Small for Gestational Age Infant;social stressor;Societies;Stress;stressor;Survivors;Temperature;Time;Tissue Differentiation;toxicant;trait;Trauma;violence exposure

PROJECT_TITLE: Stress-Air Pollution Interactions and Adolescent Neurobehavior

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunization;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: BOSTON

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: TUFTS UNIVERSITY BOSTON

ORG_STATE: MA

PHR: PROJECT NARRATIVE Recent data indicate that effective and durable immune responses are optimally generated when key antigen presenting cells (dendritic cells, DCs) enter a state of hyperactivation during which they exhibit enhanced functional capacities including robust migration to local lymph glands and sustained production of key cytokines. In mouse models of cancer, DC hyperactivation combined with lysate derived from tumors induces durable anti- tumor immune responses, even in the setting of resistance to classic immunotherapies such as checkpoint inhibitors. The studies in this proposal will use spontaneous canine osteosarcoma as a bridging animal model to credential and optimize a novel vaccine platform designed to induce hyperactivation of DCs in vivo, complete a series of tumor and immune biomarker analyses to dissect correlates of response to treatment, and create a blueprint for application of this new approach to human patients with osteosarcoma.

PI_NAMEs: LONDON, CHERYL A (contact);RICHMOND, JILLIAN M

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Activities of Daily Living;Adjuvant;Agonist;Amputation;Animal Cancer Model;Animal Model;anti-tumor immune response;Antigen-Presenting Cells;antigen-specific T cells;Antigens;aspirate;biobank;Bioinformatics;Biological;Biological Assay;Biological Markers;Biological Models;Blood;cancer genome;Cancer Model;Canis familiaris;Carboplatin;CCR1 gene;CD8-Positive T-Lymphocytes;cell free DNA;Cells;checkpoint inhibition;chemotherapy;clinical efficacy;clinical translation;Clinical Trials;Clone Cells;Collaborations;comparative genomics;conditioning;Credentialing;cytokine;Cytotoxic T-Lymphocytes;Data;Dendritic cell activation;Dendritic Cells;design;Disease;draining lymph node;Effectiveness;Elements;Enrollment;Ensure;Evolution;Excision;Exhibits;exome sequencing;Failure;Flow Cytometry;Future;Generations;Genetic;Goals;Human;IL8RA gene;Immune;Immune checkpoint inhibitor;Immune response;Immunity;Immunologic Markers;Immunologics;immunomodulatory therapies;Immunooncology;Immunotherapy;improved;in vivo;industry partner;Inflammasome;inhibitor;Interleukin-1 beta;kinase inhibitor;Link;Losartan;Lung;Lymph Node Tissue;lymph nodes;Lysophosphatidylcholines;Malignant Neoplasms;Metastatic Neoplasm to the Lung;Metastatic Osteosarcoma;Microscopic;migration;Modeling;mouse model;Mus;Nature;neoantigens;Neoplasm Metastasis;neoplastic cell;novel;novel strategies;novel therapeutic intervention;novel vaccines;Nucleotides;objective response rate;Oral;Osteosarcoma;Patients;peptide I;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Plasma;Population;Pre-Clinical Model;Primary Neoplasm;Process;Production;programmed cell death protein 1;Progression-Free Survivals;prospective;Randomized;randomized, clinical trials;Reagent;Regimen;Relapse;Residual state;resiquimod;Resistance;Resources;response;Sampling;Series;Signal Transduction;Single Nucleotide Polymorphism;Site;Somatic Mutation;standard of care;Stimulus;T cell response;T memory cell;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Tissue Sample;tool;transcriptomics;translational medicine;translational oncology;Translations;treatment response;tumor;Tumor Immunity;Tumor Markers;tumor microenvironment;Tumor-Derived;tumor-immune system interactions;Vaccination;vaccine platform;vaccine response;Vaccines;Validation;Variant;Whole Blood;Work

PROJECT_TITLE: Generation of tumor specific immunity in canine osteosarcoma through dendritic cell hyperactivation


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Pediatric;Rural Health;Social Determinants of Health

ORG_CITY: CHARLESTON

ORG_DEPT: PEDIATRICS

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE The IDeA States Clinical Trials Network has rapidly expanded the capacity to conduct clinical trials in states with a limited degree of clinical research infrastructure and a high percentage of rural and underserved children. Collaboration among the Clinical Research Centers, the Data Coordinating and Operation Center and the ECHO office at the NIH permits multi-center evaluation of high impact pediatric trials that advance the state of children's health; provides a training platform for fellows, junior faculty, and nurses; supports development of novel techniques and methodologies; and promotes dissemination of study results to improve the scientific basis for the care of affected children.

PI_NAMEs: ATZ, ANDREW M (contact);KNIGHT, LISA

PROGRAM_OFFICER_NAME: RAJU, TONSE N

PROJECT_TERMS: Address;Affect;African American;Age;Area;Attention deficit hyperactivity disorder;Caring;Characteristics;Child;Child Health;Childhood;Clinic Visits;Clinical;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Network;Collaborations;Communication;Conduct Clinical Trials;Data;Dedications;design;Development;Drug Kinetics;electronic consent;Elements;Enrollment;Ensure;Evaluation;experience;Faculty;Failure;Family;Fostering;Funding;Future;Geography;Health;Health Technology;Healthcare;Home;Household;improved;improved outcome;Infrastructure;interest;Leadership;Letters;Low income;Maps;Medical;Medical center;member;Mentors;Methodology;Monitor;Multi-Institutional Clinical Trial;National Center for Advancing Translational Sciences;Neonatal Abstinence Syndrome;neurobehavioral;neurodevelopment;novel;Nurses;Obesity;obesity-associated asthma;operation;Outcome;Participant;Patients;Pediatric Research;pediatrician;peer;Persons;Pharmaceutical Preparations;Population;Population Heterogeneity;postnatal;programs;Publications;Race;racial diversity;Recording of previous events;Research;Research Infrastructure;Research Personnel;Resources;Risk;Role;Rural;rural area;Rural Community;Schools;Science;senior faculty;Site;South Carolina;standard of care;success;Symptoms;Teacher Professional Development;Techniques;Technology;telehealth;Time;tool;Training;Transportation;underserved community;United States National Institutes of Health;Universities;virtual;Vitamin D supplementation;web-enabled;working group

PROJECT_TITLE: Trials and ReseArch Network FOR even More- South Carolina (TRANSFORM-2)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Estrogen;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Beginning in the puberty transition (PT), females have substantially increased risk for depression compared with males. This research will determine whether the PT represents a unique window of vulnerability to the impact of ovarian hormone flux and interpersonal stress, and will provide mechanistic insight on the role of estrogen in the development of depression in adolescent girls. Mentored research training in pediatric endocrinology, phenomenology of adolescent depression, and multilevel statistical analyses, will allow the candidate to achieve research independence with state-of-the-art skills necessary to advance the field of adolescent depression.

PI_NAMEs: ANDERSEN, ELIZABETH HELEN (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Acute;Adolescence;Adolescent;Affective;Affective Symptoms;Age;Area;Award;biobehavior;boys;brain circuitry;brain morphology;career;career development;child depression;Childhood;Clinical;Cognitive;cognitive control;Data;depression model;depression prevention;depressive symptoms;Development;Dimensions;Disease susceptibility;Doctor of Medicine;Doctor of Philosophy;Early Diagnosis;Early identification;Electroencephalography;Emotional;Endocrine;Endocrinology;Enrollment;Estradiol;Estrogens;Event;experience;experimental study;Female;Female Adolescents;frontal lobe;Functional disorder;Funding;Future;girls;Goals;Gonadal Steroid Hormones;Hormonal;Hormones;Hydrocortisone;Impairment;insight;Intervention;Knowledge;Laboratories;life span;Link;male;Measurement;Measures;Mediator;Menarche;Mental Depression;Mental disorders;Mentors;Moods;multilevel analysis;multimodality;National Institute of Mental Health;neural network;Neuroendocrinology;neurophysiology;Neuroregulator;novel;Ovarian hormone;Participant;Pathway interactions;Perimenopause;phenomenological models;Physiological;Positioning Attribute;Predisposition;psychologic;Psychopathology;Psychophysiology;Psychosocial Stress;Puberty;puberty transition;reproductive;Reproductive Endocrinology;reproductive hormone;Research;Research Training;response;Risk;Risk Factors;Role;Salivary;Sampling;sex;sex disparity;skills;Statistical Data Interpretation;Statistical Models;Stress;stress reactivity;Stressful Event;success;Symptoms;Testing;Time;Training;Trier Social Stress Test;Woman

PROJECT_TITLE: Defining the Neuropathophysiological Mechanisms Linking Ovarian Hormone Variability with Depression Risk in Peripubertal Girls


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: DURHAM

ORG_NAME: CYTEX THERAPEUTICS INC.

PHR: Narrative This CRP will allow Cytex to make major strides in advancing its cell-based cartilage tissue repair therapy towards a first-in-human clinical study. The biomanufacturing process will be enhanced for off-the-shelf availability and transferred to a highly qualified partner with expertise in cleanroom manufacturing of advanced cellular therapies. Meanwhile, Cytex will further strengthen and formalize its product quality requirements while engaging the US FDA in mapping final requirements for clinical study approval.

PI_NAMEs: ESTES, BRADLEY T (contact)

PROGRAM_OFFICER_NAME: WANG, XIBIN

PROJECT_TERMS: 3-Dimensional;active lifestyle;Address;Adult;advanced disease;Affect;Age;Allogenic;Anatomy;Animal Model;Applications Grants;Autologous;Automobile Driving;Biological;Biological Assay;Biological Process;Biological Products;Biomanufacturing;bone marrow mesenchymal stem cell;Bone Regeneration;Cartilage;cartilage implant;Cartilage Matrix;cartilage regeneration;cartilage repair;Cell Culture Techniques;Cell Separation;Cell Survival;Cell Therapy;Cells;Chemicals;Clinical;Clinical Research;Clinical Trials;Collaborations;commercialization;Consumption;Contracts;Cryopreservation;Data;Degenerative polyarthritis;design;Development;Devices;disability;Disease;disease model;Economic Burden;economic cost;Elderly;Ensure;Exclusion;experience;Extracellular Matrix;Face;first-in-human;Freezing;Funding;Generations;Goals;Good Manufacturing Process;Hip region structure;hip replacement arthroplasty;Histocompatibility Antigens Class II;Implant;implantable device;implantation;in vivo;joint function;joint loading;Joints;Lead;Legal patent;Lesion;Life;life span;Life Style;Major Histocompatibility Complex;manufacture;Manufacturer;Maps;Measures;Medical Device;Mesenchymal Stem Cells;Metals;Methods;Modification;older patient;Operative Surgical Procedures;Orthopedics;osteochondral repair;osteochondral tissue;Pain Free;patient population;Patients;Phase;Phase I/II Clinical Trial;pre-clinical;preclinical study;Preclinical Testing;preservation;Procedures;Process;Production;programs;Qualifying;Quality Control;Quality of life;Regenerative Medicine;repaired;Replacement Arthroplasty;research clinical testing;scaffold;Second Look Surgery;Series;Sheep;socioeconomics;Source;Surgeon;System;Techniques;Technology;Testing;Therapeutic;Time;Tissue Engineering;tissue repair;Validation;Work

PROJECT_TITLE: Unicondylar Resurfacing in an Ovine Osteoarthritis Disease Model


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Microbiome;Pediatric;Pediatric - AIDS

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: HIV exposed uninfected infants (iHEU) exhibit heightened inflammation, altered growth and higher rates of enteric infections; but mechanism(s) are unknown. Here, we will utilize a neonatal germ-free mouse model or a mouse model of enteric infection to test whether the gut microbiota of iHEU early in life cause these outcomes. Ultimately, results could inform future investigations of potential interventions to improve morbidity in iHEU.

PI_NAMEs: NYANGAHU, DONALD  (contact)

PROGRAM_OFFICER_NAME: CHIOU, CHEN-CHIA CHRISTINE C

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;adaptive immunity;Address;Age;Antibodies;antiretroviral therapy;Area;Automobile Driving;Bacteremia;Bacteria;Biological Assay;Breast Feeding;Cells;Child;Childhood;Chronic;Clinical;clinical phenotype;cohort;Colon;colonization resistance;Cryptosporidium;Development;Diarrhea;Disease;Duodenum;Enteral;enteric infection;enteric pathogen;enteropathogenic Escherichia coli;Enzyme-Linked Immunosorbent Assay;Escherichia coli Infections;Etiology;Euthanasia;exhaustion;Exhibits;falls;fecal transplantation;Feces;Functional disorder;Future;Germ-Free;Growth;gut bacteria;gut inflammation;gut microbiota;High Prevalence;high risk;HIV;HIV-exposed uninfected infant;Human;Humoral Immunities;ileum;Immune;immune activation;Immune response;Immune System Diseases;Immunity;Immunologics;Impairment;imprint;improved;infancy;Infant;Infection;Inflammation;inflammatory marker;Intervention;Intestines;Investigation;Knowledge;Lamina Propria;Lead;Life;Link;Malnutrition;Measures;microbial;microbiota;microbiota composition;Morbidity - disease rate;mortality;mouse model;Mucosal Immunity;Mus;Neonatal;neonatal mice;Nigeria;Oral;Outcome;pathogen;perinatal HIV;Plasma;Play;Pneumonia;Population;Predisposition;Pregnancy;Probiotics;pup;Recurrence;Research;Risk;Risk Factors;Role;Sampling;Severities;Signal Transduction;single-cell RNA sequencing;systemic inflammatory response;T-Lymphocyte;Testing;Therapeutic Intervention;transcriptome;transmission process;Viral;Weaning

PROJECT_TITLE: Influence of Early Life Gut Microbiota of HIV-Exposed Uninfected Infants on Inflammation, Growth and Immunity to Enteric Pathogens

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: DREXEL UNIVERSITY

PHR: PROJECT NARRATIVE Researchers at state and local health departments who produce small area estimates often face a lose-lose situation. Statistical models can be used to improve the precision of estimates, but models that overwhelm the data may produce untrustworthy estimates. This project aims to develop spatial models whose informativeness can be controlled to prevent oversmoothing, apply those methods in a comprehensive analysis of heart disease related death in Philadelphia, and package the methods in an accessible software tool.

PI_NAMEs: QUICK, HARRISON ;TABB, LONI PHILIP (contact)

PROGRAM_OFFICER_NAME: WOLZ, MICHAEL

PROJECT_TERMS: Address;Age;Age Factors;American Heart Association;Area;Bayesian Analysis;Bayesian Method;Binding;Black Box;Case Study;Cause of Death;Censuses;Cessation of life;Cities;Collaborations;Collection;Complex;Computer software;Country;dashboard;Data;Data Set;data space;Death Rate;Dependence;Development;disease disparity;Disease Surveillance;Equilibrium;Ethnic Origin;Event;experience;Face;Fright;Funding;Future;Gender;geographic disparity;Geographic Locations;Geography;Goals;Health;health data;health disparity;Health Surveys;Heart Diseases;Household;improved;Individual;insight;Intervention;Investigation;Joints;large datasets;Literature;men;Methodology;Methods;Modeling;mortality;Multivariate Analysis;Neighborhoods;Obesity;Outcome;Pattern;Peer Review;Pennsylvania;Philadelphia;Policies;Population;Prevalence;prevent;Production;Public Health;Publications;Race;racial disparity;Reporting;Research;Research Personnel;Research Project Grants;Resolution;Risk Factors;Sample Size;sex;Small-Area Analysis;Software Tools;spatiotemporal;Specific qualifier value;Standardization;Statistical Methods;Statistical Models;statistics;Subgroup;Surveys;tool;Training;Training Programs;trend;Weights and Measures;Work

PROJECT_TITLE: Small Area Estimation for State and Local Health Departments

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative  The proposed research is highly relevant to public health, as it aims to understand premature aging and the complex interplay between body and brain health in schizophrenia, a debilitating psychiatric disorder that affects almost 1% of the world’s population. We propose to develop biomarkers for premature aging across the schizophrenia lifespan using already collected clinical, cognitive, blood, and imaging data. Thus, the proposed research aligns with the NIMH’s mission to promote transformative research that paves the way toward novel neuroprotective treatment strategies in mental health.

PI_NAMEs: SEITZ-HOLLAND, JOHANNA  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Affect;Age;aged;Aging;Award;Biological;Biological Markers;Blood;Brain;brain abnormalities;brain health;Cell Aging;Cells;Clinical;clinical practice;Clinical Sciences;Cognition;Cognitive;comorbidity;Complex;Data;Data Set;Dementia;Deterioration;Development;Diagnosis;diagnostic tool;Diffusion;Disease;Elderly;Equation;evidence base;Excess Mortality;experience;Factor Analysis;Foundations;Functional disorder;Goals;Hospitals;Image;Impaired cognition;in vivo;indexing;Individual;instructor;Knowledge;Life;Life Expectancy;life span;Link;Mediator;Medical;medical schools;Medicine;Mental Depression;Mental disorders;Mental Health;Mentors;minimally invasive;Mission;Modeling;Monitor;multimodality;National Institute of Mental Health;Nerve Degeneration;neuroimaging;neuroprotection;novel;novel strategies;Outcome;Phase;Phenotype;physical conditioning;Physical Sufferings;Population;post-doctoral training;Premature aging syndrome;Process;Proteins;Psychiatry;Psychology;Psychotic Disorders;Public Health;Quality of life;Research;Research Personnel;Research Project Grants;Risk;Role;Schizophrenia;Science;Secretory Component;senescence associated secretory phenotype;skills;Solid;statistics;Structure;Tissues;Training;Translating;Translational Research;treatment strategy;Woman;Work

PROJECT_TITLE: Towards Developing Biomarkers for Premature Aging in Schizophrenia


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Gene Therapy;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Although allogeneic hematopoietic cell transplantation (allo-HCT) has the potential to cure people with blood cancers who have not responded to other treatments, disease relapse and graft-versus-host disease (GVHD) are leading causes of morbidity and mortality following this therapy. CD19-targeted chimeric antigen receptor (CAR) T cells represent an effective treatment against CD19-positive leukemia and lymphoma, and preclinical studies in a mouse model demonstrate that conventional donor-derived CD19 CAR T cells infused at the time of allo-HCT have potent anti-lymphoma activity while inducing attenuated GVHD. This innovative proposal will use genome editing with CRISPR/Cas9 to engineer donor and third-party T cell receptor knockout CD19 CAR T cells for the post-allo-HCT setting, as a strategy to decrease relapse without GVHD or graft rejection, as well as investigate the functional and mechanistic impact of this genome engineering on the immuno-metabolism of these cells.

PI_NAMEs: SMITH, MELODY  (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Advisory Committees;Affect;Allogenic;allograft rejection;anti-tumor agent;antitumor effect;Area;Attenuated;attenuation;Autologous;B-Cell Acute Lymphoblastic Leukemia;Bioinformatics;Bone Marrow;CAR T cell therapy;career;CD19 gene;Cell Count;Cell Death Induction;Cell Physiology;Cell Therapy;Cells;Cellular Metabolic Process;chimeric antigen receptor;chimeric antigen receptor T cells;Chimerism;Clinical;Clinical Data;clinical translation;Committee Members;comparison control;CRISPR/Cas technology;Data;design;Development;Disease;Donor person;Dose;Educational workshop;effective therapy;effector T cell;engineered T cells;Engineering;Engraftment;exhaustion;fatty acid oxidation;FDA approved;Foundations;Future;Generations;genome editing;Genome engineering;Goals;graft failure;Graft Rejection;graft versus host disease induction;graft vs host disease;Hematologic Neoplasms;Hematopoietic Neoplasms;Hematopoietic Stem Cell Transplantation;high risk;immune reconstitution;Immune system;Immunobiology;Immunocompromised Host;Immunology;Immunophenotyping;Immunotherapy;improved;in vivo;Incidence;innovation;Knock-out;Knowledge;knowledge base;Laboratory Study;Lead;leukemia/lymphoma;Leukemic Cell;Leukocytes;Lymphoma;Lymphoma cell;Malignant Neoplasms;Memorial Sloan-Kettering Cancer Center;Mentors;Mentorship;Metabolic;Metabolic Pathway;metabolic profile;Metabolism;Mitochondria;Morbidity - disease rate;mortality;mouse model;Mus;neoplastic cell;next generation;Non-Hodgkin's Lymphoma;novel;Outcome;Oxygen Consumption;Patients;Persons;Physicians;Positioning Attribute;pre-clinical;Pre-Clinical Model;preclinical study;prevent;programs;Records;Recurrent disease;Refractory Disease;Relapse;relapse risk;Research;Research Project Grants;Research Training;response;Scientist;skill acquisition;Source;T memory cell;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;Therapeutic Index;Time;Training;tumor;Work

PROJECT_TITLE: Investigating immunophenotype and metabolism of TCR KO donor and third-party CD19-targeted chimeric antigen receptor T cells

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Patient Safety

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Observational health data, such as electronic health records, contain a wealth of information that can help to determine the safety, effectiveness, and benefits of drugs. This K99 proposal aims to integrate knowledge embedded in the literature into graphical causal models to better characterize the effects of drug exposures. The fulfillment of these aims will advance the state- of-the-art of pharmacovigilance and drug repositioning using observational health data by discovering/validating new methods to address confounding.

PI_NAMEs: MALEC, SCOTT ALEXANDER (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Address;Adverse drug event;adverse drug reaction;Adverse event;Age;Aging;Alcoholism;Algorithms;Alzheimer's Disease;Benchmarking;causal model;Characteristics;Chronic;comorbidity;Controlled Clinical Trials;Data;data quality;Data Set;Dependence;Diagnosis;Disease;Drug Exposure;drug repurposing;Drug Side Effects;Drug usage;Effectiveness;Electronic Health Record;Etiology;Event;guided inquiry;Health;health application;health data;High Prevalence;improved;insight;Knowledge;knowledge integration;Light;Link;Literature;Manuals;Medical;Medical center;medication safety;Mentors;Methods;Naltrexone;Neurodegenerative Disorders;Outcome;Pancreatitis;Patients;Peer Review;Performance;Pharmaceutical Preparations;Pharmacological Treatment;Pharmacology;pharmacovigilance;Phase;Prevalence;prevent;Reference Standards;Research;Research Personnel;Reverse engineering;Review Literature;Safety;Selection for Treatments;side effect;Structure;Symptoms;System;Testing;Translational Research;Treatment outcome;Variant;Work

PROJECT_TITLE: Using the literature to build causal models of retrospective observational data

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative The Yale Clinical Neuroscientist Training Program (CNSTP) is uniquely designed to provide the research tools, clinical skills, and mentorship required for the transition from resident to independent faculty member. Our program seamlessly integrates research and clinical training using the vast educational and research resources at Yale and fosters trainees to become creative and innovative scientists that are equipped to successfully obtain a mentored career development award, and ultimately lead an independently funded research laboratory. Diversity, ethics and responsible conduct is of great importance to our program and so we are committed to the recruitment of women and individuals from underrepresented backgrounds in order to strengthen the diversity of our program, and to a newly created Plan for Ethical and Successful Scientific Practice that will build on our current Responsible Conduct of Research plan, all part of a program of excellence designed to develop the next generation of leaders in academic medicine.

PI_NAMEs: HAFLER, DAVID A. (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Award;Back;Basic Science;career;career development;Clinical;clinical application;Clinical Research;Clinical Skills;clinical training;Communities;Core Facility;Creativeness;Dedications;design;Development;education research;education resources;Educational process of instructing;Ethics;experience;Faculty;Fellowship;Fostering;Funding;Funding Opportunities;Future;Goals;Grant;Individual;innovation;Instruction;K-Series Research Career Programs;Knowledge;Laboratory Research;Lead;medical schools;Medical Students;Medicine;member;Mentors;Mentorship;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurology;Neurosciences;next generation;Participant;Physicians;Positioning Attribute;Process;programs;Publications;Records;recruit;Research;Research Activity;Research Design;Research Project Grants;research study;Research Training;Residencies;Resources;responsible research conduct;retention rate;Science;Scientist;Series;skills;Statistical Methods;Structure;success;Testing;tool;Training;Training Programs;Translating;Translational Research;Woman;Work;Writing


ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE The proposed studies address the important issue of immune suppression and dysfunction of tumor-reactive T cells in the tumor microenvironment that is a major barrier for successful anti-tumor immunity and immunotherapy. The proposed research has relevance to public health, because it seeks to dissect a novel suppressive mechanism and then to develop critical strategies that control immune suppression and T cell dysfunction. Thus, the findings are ultimately expected to be applicable to improve the treatments against human cancers and other diseases as well.

PI_NAMEs: PENG, GUANGYONG  (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Address;Affect;Amplifiers;anti-PD-L1;anti-PD-L1 therapy;Breast Melanoma;cancer infiltrating T cells;Cancer Patient;cancer therapy;cancer type;CD8-Positive T-Lymphocytes;Cell Aging;Cell Survival;Cell Therapy;cytokine;Development;Disease;DNA Damage;effector T cell;Energy Metabolism;Enzymes;exhaust;exhaustion;Exhibits;experimental study;Functional disorder;Generations;Human;immune checkpoint;immune checkpoint blockade;Immune response;Immune System Diseases;Immunosuppression;Immunotherapy;improved;in vivo;lipid metabolism;Lipids;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Mediator;Metabolic;Metabolic Diseases;metabolic profile;Metabolism;mitochondrial dysfunction;Modeling;Molecular;neoplasm immunotherapy;novel;novel strategies;Outcome Study;PD-L1 blockade;prevent;Process;programs;Proliferating;Public Health;Regulatory T-Lymphocyte;Rejuvenation;Reproducibility;Research;Role;senescence;senescence associated secretory phenotype;T cell therapy;T-Cell Development;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Treatment Efficacy;tumor;Tumor Immunity;tumor microenvironment;Tumor Suppression;Tumor-Derived;Up-Regulation;Writing

PROJECT_TITLE: Excessive lipid metabolism in T cell senescence and immunosuppression

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: The NIH policy requiring the consideration of sex as a biological variable has increased the inclusion of both males and females in research; however, sex-based data are not being analyzed using rigorous approaches. In this study, we will (1) identify the factors that facilitate best practices and (2) develop and disseminate resources to promote those practices.

PI_NAMEs: MANEY, DONNA L (contact);VORLAND, COLBY

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TERMS: access disparities;Data;design;Development;effective therapy;Effectiveness;Female;Funding;Gender;Goals;Health;Health Policy;Healthcare;improved;Interview;journal article;Journals;Literature;male;Methods;outreach;Peer Review;Persons;Policies;pre-clinical research;precision medicine;Process;Publications;Publishing;Reporting;Reproducibility;Research;Research Personnel;Resources;Rest;Science;Scientist;sex;sex as a biological variable;Sex Differences;Structure;Testing;Time;tool;United States National Institutes of Health;wasting;welfare

PROJECT_TITLE: SCISIPBIO: Maximizing rigor and reproducibility when considering Sex as a Biological Variable in research


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cardiovascular;Clinical Research;Heart Disease

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative This research will evaluate the effects that an artificial heart and lung machine (ECMO) has on the work load of the beating heart in patients supported because of heart problems that lead to shock. We will assess: 1) how the presence of ECMO unloads or stresses the heart with different levels of support in the cardiac catheterization laboratory, 2) evaluate how this effect varies over time and affects cardiac recovery, and 3) compare a non-invasive method to reconstruct the PV loops with the invasive gold standard in order to provide an easier way to assess those changes. The results will help us make educated decisions about the use of circulatory assist devices and clarify the physiological effects they have on the heart.

PI_NAMEs: YANNOPOULOS, DEMETRIS  (contact)

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: acute coronary syndrome;Affect;Angiography;animal data;Animal Model;Area;Artificial Heart;artificial lung;Assisted Circulation;Cannulations;Cardiac;Cardiac Catheterization Procedures;Cardiogenic Shock;Cessation of life;Chronic;Clinical;Clinical Data;cost;Critical Illness;Data;Death Rate;Deterioration;Development;Diameter;Disadvantaged;Echocardiography;EFRAC;Energy Metabolism;Environment;Evolution;experience;Extracorporeal Membrane Oxygenation;Goals;Heart;Heart Arrest;Heart-Assist Devices;hemodynamics;Hospital Mortality;Hospitalization;human data;hypoperfusion;Iatrogenesis;Image;improved;Institution;Laboratories;Left;Left Ventricular Dysfunction;Left ventricular structure;Lung;Mechanics;Methods;Morbidity - disease rate;mortality;Myocardial;Neurologic;Organ;out-of-hospital cardiac arrest;Outcomes Research;Oxygen Consumption;patient population;Patient-Focused Outcomes;Patients;Pattern;Performance;Physiologic intraventricular pressure;Physiological;Population;pressure;Publishing;reconstruction;Recovery;Research;Research Project Grants;Research Proposals;respiratory;right ventricular failure;Right Ventricular Function;Self-Help Devices;Shock;Stress;Stroke;Testing;Time;Transplantation;Uncertainty;Ventricular;Work;Workload

PROJECT_TITLE: Left ventricular physiological effects of veno-arterial ECMO support during cardiogenic shock


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Invasive fungal infections are a major cause of complications and death in people living with weakened immune systems, and there are limited treatment options and emergence of resistance to available antifungal drugs. A well-vetted target for antimicrobial drugs is the ribosome, and though the fundamental core of the ribosome is conserved between humans and fungi, we have identified unique proteins that associate with the ribosome under stresses encountered by a particular fungal pathogen, Cryptococcus neoformans, when it enters the host. This proposal will explore these novel ribosome-associated factors for roles in stress adaptation, pathogenesis, and translation regulation, and will identify those with development potential for targeting the ribosome with specificity in fungal pathogens.

PI_NAMEs: PANEPINTO, JOHN C (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: 5' Untranslated Regions;Affect;anti-fungal agents;anti-microbial drug;Antifungal Therapy;antimicrobial;Basidiomycota;Binding;biological adaptation to stress;Biology;Catalytic Domain;Cellular Stress;Cessation of life;comorbidity;Complex;Cryptococcus;Cryptococcus neoformans;Data;Defect;Development;Drug Targeting;Eukaryota;Exhibits;experimental study;Fungal Drug Resistance;fungus;Future;Goals;Growth;Heterogeneity;Homologous Gene;Human;human pathogen;Hypoxia;Immune system;immunodeficiency;Impairment;In Vitro;Intervention;Investigation;knock-down;Lung;Maps;Messenger RNA;Molecular Chaperones;mortality;mRNA capping;mRNA Decay;mutant;Mycoses;Names;novel;Oxidative Stress;pathogen;Pathogenesis;pathogenic fungus;Pathway interactions;Patients;Peptide Initiation Factors;Persons;Pharmacologic Substance;Phenotype;Phosphorylation;Process;Prokaryotic Cells;Protein Biosynthesis;Protein Isoforms;Proteins;Proteomics;recruit;Regulon;Resistance;Ribosomes;RNA;RNA Recognition Motif;RNA-Binding Proteins;RNA-Protein Interaction;Role;scaffold;Sedimentation process;Signal Pathway;Specificity;Stress;stress tolerance;Structure;Techniques;Temperature;Testing;Therapeutic;Translating;translation factor;Translation Initiation;Translational Regulation;Translations;translatome;Transplantation;Virulence;Work

PROJECT_TITLE: Ribosome Heterogeneity in Cryptococcus neoformans


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Orphan Drug;Patient Safety;Pediatric;Pediatric - AIDS;Rare Diseases;Tuberculosis

ORG_CITY: Durban

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: CENTRE/AIDS PROGRAMME/RES/SOUTH AFRICA

PHR: Project Narrative: Integrase stand transfer inhibitors (InSTI), in particular dolutegravir and bictegravir, are potent, safe, well- tolerated drugs used for the treatment of HIV infection, but we do not yet fully know how to use them in patients with HIV and tuberculosis. Drug interactions with rifampicin, a key first-line tuberculosis drug, reduces exposures to these drugs and may reduce their efficacy, so we will therefore study whether increasing the doses of these drugs can overcome drug interactions and will be safe and effective for the treatment of HIV infection. Specifically, we will examine drug exposures, safety and efficacy of dolutegravir when given twice daily (double dose) to children (20-35kg) with HIV and TB on rifampicin to provide an evidence-base for the use of this drug in this subpopulation, and we will test twice-daily bictegravir/ /emtricitabine/tenofovir alafenamide (BIC/TAF/FTC) in adults with HIV taking tuberculosis treatment to ensure drug concentration and efficacy targets are met.

PI_NAMEs: DOOLEY, KELLY E.;NAIDOO, ANUSHKA  (contact)

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: ABCB1 gene;Adult;Africa;Africa South of the Sahara;antiretroviral therapy;Area;Child;Clinical;clinically relevant;co-infection;CYP3A4 gene;Data;Dedications;Diphosphates;Dose;Drug Exposure;Drug Interactions;Drug Kinetics;Drug usage;efavirenz;effective therapy;efficacy evaluation;emtricitabine;Enrollment;Ensure;Enzymes;Epidemic;evidence base;Exposure to;Film;Formulation;Fumarates;Future;Generations;Genetic;genetic testing;Goals;healthy volunteer;HIV;HIV Infections;HIV Seronegativity;HIV Seropositivity;HIV-1;HIV/TB;Infection;inhibitor;Integrase;Investigation;Knowledge;Laboratories;Lamivudine;Measures;Medical;mortality;Patients;pediatrician;Persons;Pharmaceutical Preparations;phase III trial;pill;Plasma;Positioning Attribute;Price;Protease Inhibitor;Proteins;Publishing;Qualifying;Randomized;Recommendation;Regimen;Research;Resistance;Resistance development;Resource-limited setting;Rifampin;Safety;Sampling;South Africa;standard of care;Tablets;Tenofovir;Testing;Treatment Protocols;treatment research;Tuberculosis;tuberculosis drugs;tuberculosis treatment;UGT1A1 gene;Viral;Viral Load result;Weight;World Health Organization

PROJECT_TITLE: Second Generation InSTIs for the Treatment of HIV-1 in patients with TB co-infection on Rifampicin-based Treatment in KwaZulu Natal, South Africa


NIH_SPENDING_CATS: Microbiome;Nutrition

ORG_DEPT: BIOCHEMISTRY

PHR: The gut microbiota has a profound effect on human health and physiology, providing benefits to the host such as modulation of immune development, inhibition of pathogen colonization, digestion of dietary fibers and absorption of nutrients, while abnormalities in microbiota composition, or dysbiosis, have been implicated in numerous and diverse disease states. Microorganisms possess varied and efficient strategies for competing for nutrients in the human gut, on which they depend as a critical energy source, the molecular mechanisms of which remain poorly understood and are the focus of the studies proposed here. Our research will allow us to build an intellectual framework for the design of methods and molecules with which to remodel the composition of the gut microbiota in order to improve human health.

PI_NAMEs: SUNDBERG, ERIC JOHN (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Address;Asparagine;Bacteria;Bacterial Antibiotic Resistance;bacterial metabolism;Bacteroidetes;Binding Proteins;Biochemical;biophysical techniques;Carbohydrates;Cell surface;Collaborations;Colon Carcinoma;Complex;Consensus;design;Development;Diet;Dietary Fiber;Digestion;Disease;Disparate;dysbiosis;Employment;Endoglycosidases;Energy-Generating Resources;Environment;Enzymes;Event;Exhibits;Exoglycosidases;Gatekeeping;Genes;Genetic;Genetic Techniques;Glycobiology;Glycoproteins;Goals;Growth;gut bacteria;gut microbes;gut microbiome;gut microbiota;Health;Human;human disease;Hydrolysis;immunoregulation;improved;Individual;Inflammatory;Inflammatory Bowel Diseases;innovation;Intestines;Kinetics;Link;link protein;Mannose;Mass Spectrum Analysis;Measures;member;Membrane;Metabolism;Methods;Microbe;microbial community;microbiota;microbiota composition;microorganism;Molecular;Mucins;Mucous Membrane;novel;novel therapeutics;Nutrient;nutrient absorption;Obesity;pathogen;pathogenic bacteria;Pathway interactions;Physiology;Play;Polysaccharides;Process;Proteins;Research;Role;sensor;Specificity;Structure;Substrate Specificity;superresolution microscopy;Work

PROJECT_TITLE: Gatekeeping glycan metabolism in the human gut microbiome

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: JACKSON

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Project Narrative Dizziness and imbalance, are common complaints in service members and civilians who have been exposed to blast overpressure waves, such as those produced by explosive devices. The goal of the application is to investigate the mechanisms underlying blast- induced vestibular deficits in a rat model, which will provide insight into prevention, diagnosis and treatment of this disease.

PI_NAMEs: ZHOU, WU ;ZHU, HONG  (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: 3-Dimensional;Acute;Address;Air;Animal Model;Apoptosis;Area;Auditory;axon injury;Behavioral;Biological Markers;biomechanical model;blast exposure;Blast Injuries;Brain;Brain Stem;cell injury;Chronic;Compensation;Complex;Devices;Diagnosis;Disease;Dizziness;Ear;early detection biomarkers;Early Diagnosis;Elements;Exhibits;Explosion;Exposure to;External auditory canal;External Ear;FOS gene;Frequencies;Functional disorder;Goals;Grant;Hair Cells;Head;Head Movements;Histology;Histopathology;Hour;Inflammation;Injury;insight;Intervention;Knowledge;Labyrinth;Literature;Long-Evans Rats;Lung;Masks;Measures;Mechanics;Mediating;Microglia;Military Personnel;Modeling;Morphology;Nature;Nerve;Nerve Endings;neuroinflammation;Neurons;novel;Organ;otoconia;Outcome;Pathway interactions;Phase;Physiological;Population;Predisposition;pressure;Prevention;Process;Rattus;Recovery;Reporting;response;ribbon synapse;Rotation;service member;Shock;Signal Transduction;Site;Structure;Subgroup;Symptoms;Time;Translations;treatment program;Tube;Type I Hair Cell;United States National Institutes of Health;Vestibular dysfunction;Vestibular function;Vestibular ganglion;Vestibular Hair Cells;Vestibular nucleus structure;vestibular system;vestibulo-ocular reflex

PROJECT_TITLE: Mechanisms of Blast-Induced Vestibular Injury

STUDY_SECTION: SMI

STUDY_SECTION_NAME: Sensorimotor Integration Study Section[SMI]


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative To further enhance the ongoing fight against cancer requires scientists who can communicate across traditionally distinct research disciplines, such as those that comprise the interdisciplinary “field” of molecular and genetic epidemiology. The proposed T32 program will fulfill this need by providing exceptional training to prepare postdocs for careers as independent researchers able to decipher the underlying basis and how best to prevent and treat cancer.

PI_NAMEs: CHENG, IONA C (contact);ZIV, ELAD

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: cancer epidemiology;genetic epidemiology;Molecular Epidemiology;Training

PROJECT_TITLE: Training in the Molecular & Genetic Epidemiology of Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Clinical Research;Data Science;Diabetes;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Osteoporosis;Prevention;Sarcopenia

ORG_CITY: DOVER

ORG_NAME: DELAWARE STATE UNIVERSITY

ORG_STATE: DE

PHR: Narrative Age-related diseases such as type-2 diabetes, cardiovascular diseases, sarcopenia and osteoporosis have become a worldwide epidemic and affect the quality of life of millions. To give a global perspective, roughly 343.8 million people in the world have type-2 diabetes today, and 175 million don’t know they have diabetes at all. This project will contribute novel and non-invasive medical image analysis techniques for studying the human body composition and its changes with increasing age to achieve timely prognosis of these pathologies.

PI_NAMEs: MAKROGIANNIS, SOKRATIS  (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Abdomen;Adipose tissue;Adult;Affect;Age;age related;age related biomarkers;age related changes;age-related disease;Aging;aging related;Agreement;Anatomy;Area;Atlases;automated image analysis;Baltimore;Body Composition;Body Regions;Bone structure;Cardiovascular Diseases;Classification;Clinical;Clinical Data;clinical imaging;Computational Technique;Computer Assisted;Coronary Arteriosclerosis;Data;Data Set;deep learning;Descriptor;Deterioration;Development;Diabetes Mellitus;Diagnosis;Diagnostic;Dictionary;Disease;disease diagnostic;disorder risk;Doctor of Medicine;Doctor of Philosophy;Endocrinology;Epidemic;Epidemiology;epidemiology study;fracture risk;Gerontology;Human;Human body;Image;Image Analysis;imaging biomarker;imaging modality;imaging study;Imaging technology;in vivo;interest;Intervention;intervention effect;learning strategy;Leg;Link;longitudinal analysis;Longitudinal Studies;machine learning method;Magnetic Resonance Imaging;mathematical methods;Measures;Medical;Medical Imaging;medical schools;Metabolic;metabolic abnormality assessment;Metabolic Diseases;Metabolic syndrome;Methods;Mobility decline;models and simulation;Modernization;Monitor;Morphologic artifacts;Morphology;morphometry;Muscle;muscle form;muscle strength;Noise;Non-Insulin-Dependent Diabetes Mellitus;Normal tissue morphology;novel;Obesity;Organ;Osteoporosis;pandemic disease;Participant;Pathology;Pattern;Pennsylvania;Persons;pharmacologic;Phenotype;Physics;Physiological;Population Study;pre-clinical;Prevalence;Process;Prognosis;prognosis biomarker;Property;Quality of life;quantitative imaging;radiological imaging;Research;Risk;Risk Factors;sarcopenia;Shapes;simulation;Skeletal Muscle;statistical and machine learning;statistical learning;Stroke;substantia spongiosa;Techniques;Testing;Therapeutic Intervention;Thigh structure;Tissue Model;Tissues;ultrasound;United States;United States National Institutes of Health;virtual;Visualization;Work;X-Ray Computed Tomography

PROJECT_TITLE: Image Analysis and Machine Learning Methods for Biomarkers of Age-related and Metabolic Diseases


ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE GPCRs are involved in countless human diseases – being targeted by 25% of FDA-approved drugs. Nonetheless, the majority of them are too poorly understood for drug development. Detailed analyses of GPCR structural dynamics is critical to the discovery of new therapeutics.

PI_NAMEs: ZIAREK, JOSHUA JAMES (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Agonist;antagonist;Architecture;Arrestins;Binding;Cardiovascular Diseases;Complement;Complex;conformational conversion;Cryoelectron Microscopy;Disease;drug action;drug development;Entropy;extracellular;FDA approved;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Gastrointestinal Diseases;Goals;GTP-Binding Proteins;human disease;Inflammatory;Label;Ligand Binding;Ligands;Malignant Neoplasms;Marketing;Measurement;Measures;Membrane Proteins;Molecular;Molecular Conformation;Motion;mutant;NMR Spectroscopy;novel therapeutics;Peptides;Pharmaceutical Preparations;programs;Protein Family;Proteins;Proxy;receptor;Receptor Signaling;Relaxation;Research;Research Project Grants;Resolution;Respiratory Disease;response;Roentgen Rays;Role;Signal Transduction;Signaling Molecule;Structural Models;Structure;Techniques;Therapeutic;Translating;virtual

PROJECT_TITLE: The role of dynamics in GPCR and arrestin allostery


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Data Science;Dementia;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Alzheimer's disease (AD) is the most common form of dementia but therapeutic clinical trials for AD have largely failed. The objective of our proposal is to develop and apply multimodal machine learning methods that can identify patterns and/or clusters with similar characteristics using extremely large amounts of data such as have been generated by the Alzheimer's Disease Sequencing Project (ADSP) and other large-scale collaborative projects. We will apply these methodsto investigate AD heterogeneity and identify people with high AD risk before symptoms are observed, which might provide new avenues for better diagnosis and treatment of AD.

PI_NAMEs: DESTEFANO, ANITA L;LIN, HONGHUANG  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Acceleration;Accounting;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer’s disease biomarker;Autopsy;Biological Markers;Blood;Brain;Cerebrospinal Fluid;Characteristics;Clinical;clinical risk;Cognitive;cognitive function;Collection;combinatorial;Communities;Complex;Data;data modalities;Data Storage and Retrieval;deep learning;Dementia;Development;Diagnosis;Disease;disease heterogeneity;disease phenotype;disorder subtype;effective therapy;Elderly;endophenotype;ethnic diversity;Ethnic Population;European ancestry;feature selection;follow-up;Future;Gene Expression Regulation;gene interaction;gene regulatory network;Genes;Genetic;Genetic Predisposition to Disease;genetic risk factor;Heterogeneity;high risk;Human;Image;Impaired cognition;Individual;innovation;insight;Intervention;learning network;Machine Learning;machine learning algorithm;machine learning framework;machine learning method;machine learning model;Measures;Medicine;Methods;Modality;model building;Modeling;Molecular;multimodal data;multimodal learning;multimodality;Multiomic Data;National Institute on Aging;Nature;Nerve Degeneration;neuroimaging;Non-linear Models;Ontology;Participant;Pathogenesis;Pattern;Persons;phenotypic data;Plasma;Population Heterogeneity;Prevention strategy;Resources;risk stratification;Sampling;Statistical Models;supervised learning;Symptoms;Therapeutic;Therapeutic Clinical Trial;therapeutic target;Tissues;unsupervised learning;Weight

PROJECT_TITLE: Assessing Alzheimer disease risk and heterogeneity using multimodal machine learning approaches

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Lung;Neurosciences

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: PROJECT NARRATIVE The lateral hypothalamus (LHA) is thought to function as a respiratory chemoreceptor region by regulating breathing in response to changes in CO2/H+. However, mechanisms underlying this function are poorly understood. The main goal of this project is to identify CO2/H+ activated LHA neurons, characterize how they sense changes in CO2/H+, and selectively manipulate these cells to determine their contribution to baseline breathing and the ventilatory response to CO2.

PI_NAMEs: KHUU, MAGGIE ANN (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Anatomy;Animals;Arousal;awake;Behavior;Brain;Brain region;Brain Stem;Breathing;Carbon Dioxide;Cell Nucleus;cell type;Cells;Chemoreceptors;Data;Electrophysiology (science);energy balance;Excision;Foundations;Genetic;genetic approach;Goals;Heterogeneity;Homeostasis;hypocretin;Hypothalamic structure;In Vitro;in vivo;Infusion procedures;Label;Lateral;Mediating;Metabolic;Metabolism;Microdialysis;Modality;Molecular;Mus;Neurons;novel;Outcome;Positioning Attribute;Rabies;Reflex action;Regulation;Research;Research Personnel;respiratory;Respiratory Center;Respiratory physiology;response;Role;Sensory;Sleep;Sleep Apnea Syndromes;Slice;Source;Synapses;Techniques;Testing;Training;transcriptomics;Unconscious State;uptake;wasting;Work

PROJECT_TITLE: Identification of chemosensitive cells within the lateral hypothalamus