ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Activity;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Over four million stroke survivors currently living in the United States are unable to walk independently in the community. To increase the effectiveness of gait rehabilitation, it is critical we develop therapies that are based on an understanding of brain adaptations that occur after stroke. This project will be an important step towards the development of a promising therapeutic approach that utilizes brain stimulation and high intensity treadmill training to increase neural drive and walking capacity in stroke survivors and further understand patient- specific responses to prescribe custom walking treatments.

PI_NAMEs: MADHAVAN, SANGEETHA  (contact)

PROJECT_TERMS: Acute;Adjuvant;Adult;Aerobic;Affect;Ankle;Biomechanics;Brain;Brain-Derived Neurotrophic Factor;Cardiovascular Diseases;Clinical;Clinical Data;Communities;Community Participation;cost effectiveness;Custom;Data;demographics;design;Development;Educational Intervention;Effectiveness;Equilibrium;Exercise;exercise intensity;exercise program;Exhibits;follow-up;functional independence;Gait;gait rehabilitation;Gait speed;gait symmetry;Genetic Polymorphism;Genetic Variation;Genotype;Goals;Health;Home;Impairment;improved;improved outcome;Individual;innovation;insight;interest;Interval training;Intervention;Learning Skill;Lesion;Long-Term Effects;Lower Extremity;Measures;Methods;Mission;Motor;Motor Cortex;motor learning;motor rehabilitation;Motor Skills;Movement;Muscle;neural;Neuroanatomy;neurological rehabilitation;neuromechanism;neurophysiology;neuroregulation;Outcome;Outcome Measure;Output;Participant;patient response;Patients;Persons;post stroke;predicting response;Prediction of Response to Therapy;Quality of life;Recovery;Rehabilitation therapy;Reporting;Research;Research Personnel;responders and non-responders;Risk;Serum;skills;skills training;sound;spatiotemporal;Speed;Stroke;stroke rehabilitation;stroke survivor;success;Synapses;Techniques;Therapeutic;therapy development;Time;tool;Training;transcranial direct current stimulation;Transcranial magnetic stimulation;treadmill;treadmill training;United States;United States National Institutes of Health;Upper Extremity;Variant;Walking;walking program;walking speed

PROJECT_TITLE: Cortical priming to optimize gait rehabilitation post stroke

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: STILLWATER

ORG_COUNTRY: UNITED STATES

ORG_DEPT: SOCIAL SCIENCES

ORG_FIPS: US

ORG_NAME: OKLAHOMA STATE UNIVERSITY STILLWATER

ORG_STATE: OK

PHR: PROJECT NARRATIVE Rates of cognitive impairment are disproportionately high among older adults in rural areas compared to those in urban areas. The proposed project examines rural-urban cognitive health disparities and how the social environment influences cognitive function in later life. By increasing our understanding of the social mechanisms contributing to these geographic disparities, this project is intended to identify novel targets for assessment and intervention to reduce the burden of cognitive impairment on individuals, families, and the health care system across rural and urban areas.

PI_NAMEs: ROTH, ADAM RONALD (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Adopted;Age;Age-associated memory impairment;aged;aging related;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Area;Characteristics;Cities;Cognitive;Cognitive aging;cognitive function;cognitive testing;Communities;Data;Dementia;dementia risk;Development;Disparity;Ecological momentary assessment;Education;Environmental Risk Factor;Etiology;Event;experience;Family;Frequencies;Friends;geographic disparity;Geography;Goals;Health;health disparity;Healthcare Systems;Impaired cognition;Impairment;Indiana;Individual;insight;Intervention;Interview;Knowledge;late life;Lead;Life;Link;Literature;Longevity;Measures;Mediating;Meta-Analysis;Methods;Modeling;Neurobehavioral Manifestations;novel;novel strategies;Occupational;older adult;Older Population;Participant;Pathway Analysis;Pathway interactions;Peripheral;Persons;Policies;Prevalence;Probability Samples;promote resilience;Research;residence;Resources;Risk Reduction;Role;Rural;rural area;rural dwellers;Rural Population;Sampling;Sampling Studies;smartphone application;social;social contact;Social Environment;Social Interaction;social interventions;Social Network;Social Sciences;socioeconomics;Surveys;Testing;urban area;urban disparity;Workplace

PROJECT_TITLE: Social Mechanisms of Cognitive Aging Disparities in Rural and Urban Older Populations

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: COLLEGE STATION

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

ORG_STATE: TX

PHR: Project Narrative  While heavy alcohol intake causes long-lasting changes in the brain that are likely to contribute to pathological alcohol use and relapse, little is known about how to treat alcohol use disorder by reversing these changes. The studies in this proposal seek to reverse the connectivity between two brain cells recruited by alcohol drinking in animals by strengthening extinction-associated mechanisms to normalize the cell activity and thereby persistently decrease alcohol seeking and relapse. The results will provide new therapeutic approaches to reduce relapse to alcohol use.

PI_NAMEs: WANG, JUN  (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Abstinence;addiction;Address;Affect;alcohol abuse therapy;Alcohol consumption;alcohol prevention;alcohol relapse;alcohol seeking behavior;alcohol use disorder;Alcohols;Anatomy;Animals;Behavior;Behavioral;Brain;brain cell;cell type;Chronic;Clinical;Corpus striatum structure;Disinhibition;Dopamine;Extinction;Globus Pallidus;Goals;Habenula;Homosynaptic Depression;Human;in vivo;innovation;Knowledge;Label;Light;Long-Term Depression;Long-Term Potentiation;Measures;Mediating;Methodology;Molecular;Neurons;neurotransmission;Normal Cell;novel;novel strategies;novel therapeutic intervention;optogenetics;Output;Pathologic;Pathway interactions;Pharmaceutical Preparations;Positioning Attribute;Prefrontal Cortex;recruit;Relapse;Research;Self Administration;Stains;Synapses;Synaptic plasticity;Techniques;Testing;Thalamic structure;Therapeutic;Time;Tissues;Training

PROJECT_TITLE: Striatal ensemble plasticity in alcohol use disorder

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: DALLAS

ORG_DEPT: CHEMISTRY

ORG_NAME: SOUTHERN METHODIST UNIVERSITY

PHR: Project Narrative The project involves the design, synthesis, and evaluation of new antibiotics to treat infections due mycobacterial pathogens, including both Mycobacterium tuberculosis as well as nontuberculous mycobacterial infections, such as Mycobacterium abscessus. These infections are extremely difficult to treat, requiring multidrug regimens that are administered over a lengthy period of time (months to years) often with poor clinical outcomes. We will develop newly discovered potent antimycobacterial agents with the objective of producing an orally bioavailable drug candidate with improved specificity for mycobacteria.

PI_NAMEs: BUYNAK, JOHN D (contact);KOROTKOV, KONSTANTIN V;ROHDE, KYLE H

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: Acylation;Address;Anabolism;analog;Anti-Bacterial Agents;antibiotic design;Antibiotics;antimicrobial;Antimycobacterial Agents;Bacteria;Biochemical;Biochemistry;Biological;Biological Availability;Biology;carbapenemase;Carbapenems;Cell Wall;Chemicals;Clinical;crosslink;Crystallography;Cysteine;Data;design;Development;drug candidate;drug discovery;Drug Kinetics;Enzymatic Biochemistry;Evaluation;Genetic;Genus Mycobacterium;Goals;Homeostasis;Hydrolysis;improved;In Vitro;in vitro activity;in vivo;Infection;inhibitor;insight;interest;Lactamase;Lactams;Lead;lead optimization;Libraries;Mediating;Meropenem;Methodology;Microbiology;Modification;Monobactams;mouse model;multidisciplinary;mycobacterial;Mycobacterium abscessus;Mycobacterium avium Complex;Mycobacterium Infections;Mycobacterium tuberculosis;non-tuberculosis mycobacteria;non-tuberculous mycobacterial infection;novel;operation;Oral;Outcome;pathogen;Patient-Focused Outcomes;Penicillin-Binding Proteins;Peptidoglycan;Peptidyltransferase;Pharmaceutical Preparations;pharmacologic;Plasma;Positioning Attribute;Predisposition;Prodrugs;Property;Proteins;Qualifying;Regimen;Research;Resistance;resistant strain;Role;scaffold;Serine;Specificity;stem;structural biology;Structure-Activity Relationship;Synthesis Chemistry;Therapeutic;therapeutic target;Time;tool;Transmembrane Transport;Treatment Protocols;tuberculosis treatment;VDAC1 gene

PROJECT_TITLE: Optimization of Atypical Antimycobacterial Carbapenem Antibiotics


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Clinical Research;Disability Research;Hearing Loss;Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation

ORG_CITY: DURHAM

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE The proposed research is relevant to public health because falls result in significant morbidity, mortality and disability. The current proposal seeks to characterize factors that explain the association between falls and hearing loss. This work addresses the NIDCD’s strategic priority area of improving treatment for hearing and balance problems as the proposed project will identify appropriate targets for intervention to reduce the societal and healthcare burden of falls in individuals with hearing loss.

PI_NAMEs: RISKA, KRISTAL MILLS (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Accidents;Address;age related;Area;Audiology;Auditory;Awareness;Caring;Case/Control Studies;Cessation of life;Cognitive;Communities;cost;Cues;Diagnosis;disability;Dose;Enrollment;Equation;Equilibrium;Event;Fall prevention;fall risk;falls;Fatigue;Gait;Goals;Health;Healthcare;healthcare burden;Hearing;Hearing Aids;hearing impairment;hearing loss treatment;High Prevalence;improved;Individual;innovation;Intervention;Link;Measures;Mediating;Modeling;Morbidity - disease rate;mortality;Musculoskeletal Equilibrium;National Institute on Deafness and Other Communication Disorders;novel;older adult;Otolaryngology;Outcome Study;Participant;Pathway interactions;patient population;Patients;Perception;Performance;Peripheral;Physiological;Prevalence;Prevention program;programs;prospective;psychosocial;Psychosocial Factor;Public Health;public health relevance;Questionnaires;rehabilitation strategy;Rehabilitation therapy;Research;Research Design;response;Risk Factors;Rotation;Safety;Sampling;targeted treatment;treatment strategy;Vestibular dysfunction;Vestibular loss;vestibular reflex;vestibular system;Work

PROJECT_TITLE: Identifying mechanisms between hearing loss and falls

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: HOUSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative  NANOG directs access to stem cell pluripotency. NANOG coordinates interactions with and between key players Oct4, Sox2 and hundreds of other proteins to activate pluripotency genes and repress differentiation genes. The project will probe the fundamental molecular mechanisms of human NANOG structure and function in stem cell pluripotency.

PI_NAMEs: FERREON, JOSEPHINE CHU (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Adopted;Aging;Alleles;Behavior;Biochemical;Biological Assay;Biophysics;Cancer Relapse;cancer stem cell;Cells;Cellular biology;chemotherapy;ChIP-seq;Chromatin;Chromatin Loop;cofactor;Communication;Dependence;Development;diagnostic biomarker;Differentiated Gene;Disease;DNA;DNA Binding;Dominant-Negative Mutation;Dose;efficacy evaluation;Elements;embryonic stem cell;Epiblast;Epigenetic Process;Fluorescence;fluorescence imaging;fluorescence lifetime imaging;Fluorescence Recovery After Photobleaching;Fluorescence Resonance Energy Transfer;Fortification;Funding;Genes;Genomics;Hi-C;Human;human embryonic stem cell;implantation;In Vitro;innovation;insight;Investments;Lead;Link;Malignant Neoplasms;Mediating;Microscopy;Molecular;Molecular Probes;Mouse Embryonic Stem Cells;Mus;Nature;novel;overexpression;Peptides;Physical condensation;Play;pluripotency;prevent;prion-like;Process;promoter;Property;Proteins;recruit;Reporting;Repression;Research Personnel;Resistance;Role;self assembly;self-renewal;single molecule;single-molecule FRET;Source;Spectrum Analysis;spheroids;Stem cell pluripotency;Structure;System;Techniques;Therapeutic;Time;transcription factor;Translating;tumor;tumor growth;Work

PROJECT_TITLE: Structure and Functionof Nanog in Stem Cell Pluripotency

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Immunotherapy;Lung;Lung Cancer

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE Immune checkpoint blockade therapy has changed the treatment paradigm of lung cancer, a very aggressive cancer with leading cause of cancer-related deaths; however, most patients fail to respond to it, and many of patients who initially respond to treatment eventually experience recurrence. The research strategy proposed herein seeks to develop an innovative method to specifically access circulating exosomes from lung cancer patients via characterizing these disease-associated exosomes to explore molecular signatures associated with therapeutic outcome. The technology developed will help physicians to accurately predict and identify patients who are the responders and non-responders during a course of treatment, as well as identify resistant biomarkers and druggable targets for future therapeutic modalities.

PI_NAMEs: DAUNERT, SYLVIA  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Advanced Malignant Neoplasm;Aftercare;anti-cancer;anti-PD-1/PD-L1;anti-PD-L1 therapy;Archives;Attention;Biological Markers;Bioluminescence;Biopsy;Body Fluids;cancer diagnosis;Cancer Etiology;Cancer Patient;Cancer Prognosis;cancer therapy;Cells;Cessation of life;Clinical;data integration;design;Detection;Diagnosis;diagnostic tool;Disease;Disease Progression;druggable target;Early identification;Engineering;exosome;experience;FDA approved;Future;Genetic Engineering;Goals;Human;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;Immune system;immune-related adverse events;innovation;intercellular communication;Investigation;Label;Lipids;Malignant neoplasm of lung;Malignant Neoplasms;men;Methods;Modality;Molecular Analysis;Molecular Profiling;Monitor;mortality;Mutation;nanoparticle;next generation sequencing;non-invasive monitor;Non-Small-Cell Lung Carcinoma;novel;Nucleic Acids;Patient Monitoring;Patients;Peripheral;Physicians;Population;Prediction of Response to Therapy;predictive marker;programmed cell death ligand 1;Proteins;real time monitoring;Recurrence;Research;Resistance;responders and non-responders;response;Sampling;screening;Serum;Source;success;Surface;Survival Rate;Technology;Testing;Therapeutic;therapy outcome;Time;Tissues;tool;Transcript;Treatment Efficacy;Treatment outcome;treatment response;tumor;Tumor Burden;Tumor Markers;tumor progression;Tumor-Derived;Untranslated RNA;Woman

PROJECT_TITLE: Noninvasive monitoring of therapeutic response to immune checkpoint inhibitors using circulating exosomes in non-small cell lung cancer

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Neurodegenerative diseases, such as spinal bulbar muscular atrophy (SBMA) and frontotemporal dementia (FTD), are a major burden on patients and their caregivers. These diseases are progressive and lethal, and no treatments exist. This work is significant because we will study how cells normally process the proteins that aberrantly accumulate in SBMA and FTD, potentially revealing new drug targets.

PI_NAMEs: GESTWICKI, JASON E (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Acceleration;Affinity;Affinity Chromatography;Androgen Receptor;Binding;Binding Sites;Biological Models;Biology;biophysical techniques;Biophysics;C-terminal;Calorimetry;Caregivers;Cell model;Cells;Chemicals;Client;Collaborations;combinatorial;comparative;Complex;Contacting Client;Decision Making;design;Development;Disease;Drug usage;drug-like compound;Failure;Fluorescence Polarization;Frontotemporal Dementia;Funding;Glues;Goals;Guanine Nucleotide Exchange Factors;Heat-Shock Proteins 70;induced pluripotent stem cell;innovation;insight;Knowledge;Laboratories;Learning;Libraries;Ligands;Logic;Maps;MAPT gene;Mass Spectrum Analysis;Mediating;Methods;Modeling;Molecular;Molecular Chaperones;Mutagenesis;Mutation;Nerve Degeneration;Neurodegenerative Disorders;new therapeutic target;next generation;novel therapeutics;Nucleotides;Oncology;Patients;polyglutamine;prevent;Process;Progressive Disease;protein aggregation;protein aminoacid sequence;Protein Inhibition;protein protein interaction;Proteins;proteostasis;Quality Control;Reagent;recruit;Role;Scanning;Signal Transduction;small molecule;spinal and bulbar muscular atrophy;Spinobulbar Muscular Atrophy;Structure;Surface;System;tau Proteins;Technology;Tertiary Protein Structure;Testing;therapeutic development;Triage;ubiquitin-protein ligase;Work

PROJECT_TITLE: Molecular Chaperones and Small Molecules

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: MH

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: WORCESTER

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: WORCESTER POLYTECHNIC INSTITUTE

ORG_STATE: MA

PHR: NARRATIVE Develop, evaluate, and make useful new computational charge-based brain modeling engine operating from first principles.

PI_NAMEs: MAKAROFF, SERGEY N (contact)

PROGRAM_OFFICER_NAME: BENNETT, YVONNE MARIE

PROJECT_TERMS: Action Potentials;Adopted;Affect;algorithmic methodologies;Algorithms;Anatomy;Animals;Anisotropy;Astacoidea;Axon;Biological;bone;Boundary Elements;Brain;brain based;Cell membrane;Cells;Cephalic;Cerebellum;Cerebrum;Charge;Clarkia;Clinical;Clinical Data;Computer Hardware;Computer software;Computers;cranium;Data;Deep Brain Stimulation;density;Deposition;Development;Devices;dosage;Electric Stimulation;electrical potential;Electroconvulsive Therapy;Electromagnetics;Elements;Extracellular Space;Fatty acid glycerol esters;Fiber;Fishes;Generations;Geometry;Head;Hour;Implant;improved;innovation;Interneurons;Magnetic Resonance Imaging;Magnetism;Magnetoencephalography;Meninges;meter;Methods;microstimulation;millimeter;Modality;Modeling;Modernization;multi-scale modeling;Muscle;myelination;neural;Neurons;novel;Numeric Rating Scale;open source;Patients;Population;predictive modeling;Procambarus;Protocols documentation;Resolution;response;Scalp structure;simulation;Skin;source localization;Speed;Stream;Surface;Thinness;Time;Tissues;Transcranial magnetic stimulation;Turtles

PROJECT_TITLE: Charge-Based Brain Modeling Engine with Boundary Element Fast Multipole Method

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-Q(91)S]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: RICHMOND

ORG_DEPT: SURGERY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Narrative The United for Health Equity-Living PDX Program (U4HELPP) seeks to develop, characterize and test >500 new patient-derived xenograft (PDX) models from underrepresented patient populations such that our research studies can more adequately represent the diverse patient population that our cancer center serves.

PI_NAMEs: HARRELL, JOSHUA (CHUCK) ;TREVINO, JOSE G. (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Affect;Award;Bioinformatics;biomedical referral center;Biometry;black patient;Black Populations;Black race;black women;Breast;Breast Cancer Detection;Cancer Biology;Cancer Center;Cancer Etiology;cancer health disparity;Cancer Model;cancer type;Cellular biology;Cessation of life;Clinic;Clinical;Clinical Investigator;Clinical Management;Clinical Research;Clinical Trials;cohort;Colon;Communication;Communities;Cryopreservation;Data;Development;Diagnosis;Discipline;Disease;disorder subtype;Disparity;Environment;Epidemiology;epigenetic regulation;ethnic disparity;ethnic diversity;Ethnic Population;experience;Fostering;Foundations;Funding;gastrointestinal;Generations;Genes;Genetic;Genomics;Goals;Grant;Growth;Gynecologic;Health;Health Disparities Research;health disparity;health equity;improved;Incidence;innovation;insight;Institution;inter-institutional;Investigational Drugs;Liver;Lung;Malignant Breast Neoplasm;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Metadata;Minority Groups;Modeling;Molecular;Molecular Profiling;molecular subtypes;mortality;multidisciplinary;Neoplasm Metastasis;novel;novel drug combination;novel therapeutic intervention;Oncology;Pancreas;Pancreatic Adenocarcinoma;Pathway interactions;patient derived xenograft model;patient population;Patients;Peritoneal;peritoneal cancer;Peritoneal Diseases;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Pilot Projects;Population Heterogeneity;Positioning Attribute;pre-clinical;Pre-Clinical Model;precision medicine;programs;prospective;Proteins;proteogenomics;Proteomics;Race;racial disparity;racial diversity;racial health disparity;racial population;Refractory;repository;Research;Research Personnel;Research Project Grants;research study;Research Support;Resources;response;Role;safety net;Structure;Surgeon;System;targeted treatment;Testing;Therapeutic;therapeutic evaluation;therapeutically effective;Translating;Translational Research;treatment response;triple-negative invasive breast carcinoma;tumor;Underrepresented Minority;Underrepresented Populations;understudied cancer

PROJECT_TITLE: United for Health Equity - Living PDX Program (U4HELPP)


NIH_SPENDING_CATS: Biotechnology;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: TREVINO, JOSE G. (contact)

PROJECT_TERMS: Advocate;Award;Cancer Center;Cancer Patient;cancer prevention;cancer type;Clinical Oncology;Clinical Trials;Collaborations;Communication;Communities;Data Commons;Development;Disparity;Doctor of Philosophy;Ensure;Event;Feedback;Funding;Gastrointestinal tract structure;Goals;Grant;Gynecologic;Health;health equity;Healthcare Systems;Information Dissemination;Infrastructure;innovation;Institution;interest;Leadership;Link;Lung;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;meetings;member;Modeling;Monitor;Operative Surgical Procedures;Organoids;outreach;patient derived xenograft model;patient oriented;Patients;Personnel Management;Pilot Projects;Policies;Procedures;Productivity;Program Research Project Grants;programs;repository;Research;Research Project Grants;Resources;safety net;Sampling;Science;symposium;synergism;Technology;tumor;Underrepresented Minority;Universities;Urogenital Cancer;Virginia;Wages

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: KOBLINSKI, JENNIFER E (contact)

PROJECT_TERMS: Advanced Malignant Neoplasm;advanced system;Archives;Bioinformatics;Biological Specimen database;Black Populations;Black race;Breast;Cancer Center;cancer subtypes;cancer type;Carcinomatosis;central database;Characteristics;Clinical;Collaborations;Collection;Communication;Communities;Data;Data Commons;Development;Diagnosis;Educational workshop;Equity;ethnic diversity;ethnic minority population;gastrointestinal;Genitourinary system;Genomics;Gynecologic;Health Disparities Research;health equity;Histologic;immunohistochemical markers;improved;Investigation;Latinx;Libraries;Link;Lung;Malignant Breast Neoplasm;Malignant Neoplasms;Massey Cancer Center at the Virginia Commonwealth University;meetings;Minority Groups;Modeling;Molecular;multiple omics;operation;Organoids;Pancreas;Pancreatic Adenocarcinoma;patient derived xenograft model;patient population;Patients;Peritoneal;personalized approach;Pilot Projects;Population;Preclinical Testing;Primary Neoplasm;Program Research Project Grants;programs;Quality of Care;racial diversity;racial minority population;relational database;repository;Research;Research Project Grants;Research Support;RNA;safety net;Sampling;Site;Specimen;System;therapeutic development;Tissue Expansion;Tissue Harvesting;tumor;Tumor Tissue;Underrepresented Minority;Underrepresented Populations;Universities;Virginia

PROJECT_TITLE: PDX Core


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cannabinoid Research;Clinical Research;Diabetes;Genetics;Human Genome;Nutrition;Obesity;Therapeutic Cannabinoid Research

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE The proposed research is relevant to public health as it focuses on understanding the mechanisms controlling the differentiation and function of enteroendocrine (EE) cells, key regulators of appetite regulation and insulin secretion. Completion of this proposal will highlight transcriptional and epigenetic factors that can induce EE hormone production and the mechanism(s) behind EE cell dysregulation in obesity and type 2 diabetes mellitus (T2DM), allowing for identification of new targets for therapeutics to improve appetite control and insulin secretion. Thus, this research has the potential to improve the health of millions of people with obesity and T2DM.

PI_NAMEs: ZEVE, DANIEL RICHARD (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Address;Agonist;Amino Acids;Appetite Regulation;ATAC-seq;Attenuated;Automobile Driving;Award;Bioinformatics;Boston;career development;Cell Differentiation process;cell growth;Cell Physiology;cell type;Cells;Childhood;CNR1 gene;Co-Immunoprecipitations;Collaborations;comparison control;CRISPR/Cas technology;cytokine;Cytokine Signaling;Data;design;Desire for food;Development Plans;Developmental Biology;directed differentiation;Disease;Doctor of Philosophy;Duodenum;Endocrinologist;Enhancers;Enteroendocrine Cell;Enzyme-Linked Immunosorbent Assay;Epigenetic Process;epigenetic regulation;experience;Exposure to;FFAR1 gene;Flow Cytometry;Foundations;FOXO1A gene;Future;Gastrointestinal tract structure;Gene Expression;Genes;Genetic Transcription;Glucose;Goals;GPR119 receptor;Health;Homeobox;Hormonal;hormonal signals;Hormone secretion;Hormones;Human;Hydrocortisone;Immunofluorescence Immunologic;improved;incretin hormone;Inflammatory;inhibitor;innovation;Insulin;insulin secretion;Interleukin-6;Intestines;knockout gene;MAPK8 gene;Mediating;Medical;Mentors;Metabolism;Methods;Modeling;Molecular;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutic intervention;Nutrient;Obesity;obesity development;Obesity Epidemic;Organoids;Palmitates;Pediatric Hospitals;Persons;Physiological;Play;Production;Proteins;Public Health;Rectum;Regulation;Research;Resources;response;rimonabant;Role;Signal Induction;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;small molecule;SP600125;stem cells;System;Testing;Time;transcription factor;Transcriptional Regulation;treatment strategy;Twin Multiple Birth;United States;Up-Regulation;Volatile Fatty Acids

PROJECT_TITLE: Mechanisms mediating human enteroendocrine cell differentiation and function

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Pancreatic Cancer;Racial and Ethnic Minority Health Research;Rare Diseases;Women's Health Research

PI_NAMEs: LIU, JINZE  (contact)

PROJECT_TERMS: Address;African ancestry;Awareness;Basic Science;Benchmarking;Bioinformatics;bioinformatics pipeline;Bioinformatics Shared Resource;bioinformatics tool;Biological Markers;Biometry;Black race;Breast Cancer Patient;Cancer Center;Cancer Research Project;Cells;central database;Cleavage Under Targets and Release Using Nuclease;Clinical Medicine;computerized data processing;Data;data analysis pipeline;Data Commons;data management;data sharing;data standards;Data Storage and Retrieval;Databases;Dedications;design;Development;Discipline;Disparity;DNA;DNA sequencing;Drug Combinations;Ensure;European ancestry;Experimental Designs;Future;Gene Expression;genetic variant;Genome;Genomics;Goals;good laboratory practice;health equity;Health Insurance Portability and Accountability Act;human reference genome;improved;informatics shared resource;Length;Malignant Breast Neoplasm;Malignant Neoplasms;member;Methodology;Minority;Molecular;operation;Pancreatic Adenocarcinoma;pancreatic cancer patients;parallelization;patient derived xenograft model;Pharmaceutical Preparations;Pharmacotherapy;Pilot Projects;Procedures;programs;Protein Isoforms;Proteomics;Protocols documentation;Quality Control;Randomized;reference genome;Reproducibility;Research;Research Design;Research Project Grants;Resources;response;Sample Size;Sampling;Secure;single-cell RNA sequencing;Specific qualifier value;Statistical Data Interpretation;statistics;Structure;System;transcriptome sequencing;Variant;Wages

PROJECT_TITLE: Bioinformatics Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Orphan Drug;Pancreatic Cancer;Precision Medicine;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

PI_NAMEs: WOODS, NICHOLAS TAYLOR (contact)

PROJECT_TERMS: Back;Benchmarking;Biological Assay;black patient;Black Populations;Black race;Cachexia;cancer health disparity;Caring;Cells;Characteristics;Chemoresistance;chemotherapy;Chromatin;Classification;Cleavage Under Targets and Release Using Nuclease;Clinical;Clinical Management;clinically relevant;cohort;Data;design;Development;Disease;Disparity;Early Therapeutic-Clinical Trials Network;Epigenetic Process;epigenetic silencing;ethnic diversity;ethnic health disparity;Ethnic Origin;Exhibits;experience;EZH2 gene;Face;gene repression;genetic manipulation;Genetic Transcription;Goals;health disparity;health equity;Hispanic Populations;improved;Incidence;Inflammatory;Knock-out;Latino;Libraries;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Mass Spectrum Analysis;Metabolic;Methods;model building;Modeling;Molecular;molecular marker;molecular subtypes;mRNA Expression;multiple omics;Multivariate Analysis;mutant;new therapeutic target;Organoids;Outcome;Pancreatic Ductal Adenocarcinoma;pancreatic tumorigenesis;Pathway interactions;patient derived xenograft model;patient response;Patient-Focused Outcomes;Patients;Polycomb;Population Heterogeneity;Precision therapeutics;Prediction of Response to Therapy;progenitor;programs;promoter;Proteins;Proteome;proteomic signature;Proteomics;Race;racial diversity;racial health disparity;racial population;recruit;Refractory;Regulation;Repression;Repressor Proteins;Research;Research Project Grants;Resistance;response;RNA;Role;S-Phase Fraction;Socioeconomic Status;socioeconomics;Specific qualifier value;statistics;System;Therapeutic;transcriptome sequencing;Treatment outcome;treatment response;treatment strategy;tumor;Tumor stage;ubiquitin ligase;Work

PROJECT_TITLE: Research Project 1 PDAC Molecular Subtypes Contribute to Cancer Health Disparities


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Psychosis;Rehabilitation;Schizophrenia;Serious Mental Illness

ORG_CITY: Columbus

ORG_DEPT: PSYCHIATRY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Social cognitive impairments are highly prominent in psychotic disorders and have been linked to social and functional outcomes beyond the impact of other illness-related factors (i.e., psychiatric symptoms, nonsocial cognition), yet available treatments for social and social cognitive dysfunction are limited in their effectiveness. Despite recognition as an area of clinical relevance and unmet need, the brain-behavior mechanisms that give rise to social cognitive impairment in psychosis remain poorly characterized, thus limiting our attempts to target primary sources of observed dysfunction. The proposed study will examine the neural bases of mentalizing, a key social cognitive process in psychosis, and its association with clinical and real-world functioning in a transdiagnostic sample of young adults with first-episode psychosis.

PI_NAMEs: MOE, AUBREY M. (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Activities of Daily Living;Address;animation;Area;base;Behavior;Behavioral;behavioral construct;Behavioral Mechanisms;Belief;biobehavior;Brain;brain based;brain behavior;Brain region;career;Clinical;Clinical Research;clinically relevant;Cognition;Cognitive;cognitive function;cognitive neuroscience;cognitive performance;cognitive process;Cognitive remediation;cognitive task;Coupled;daily functioning;Data;Data Collection;Development;Devices;Diagnostic;Early Intervention;early psychosis;Ecological momentary assessment;Effectiveness;Enrollment;Exhibits;experience;Feeling suicidal;first episode psychosis;Foundations;Functional disorder;Functional impairment;Functional Magnetic Resonance Imaging;functional outcomes;Future;Goals;Health Technology;Illness impact;Impaired cognition;Impairment;improved;indexing;Individual;innovation;Intervention;Intervention Studies;Investigation;Knowledge;Laboratories;Link;Measures;Medial;Mental Processes;mental state;mentalization;Mentors;mHealth;multimodality;Nature;network dysfunction;neural;Neurobiology;Neurocognition;neuromechanism;Neurophysiology - biologic function;novel therapeutics;Occupational;Outcome;Outcome Measure;outcome prediction;Participant;Performance;performance based measurement;Persons;Phase;Prefrontal Cortex;psychiatric symptom;Psychoses;psychosocial;Psychotic Disorders;recruit;response;Sampling;skills;social;Social Behavior;social cognition;social deficits;Social Functioning;social influence;Social Interaction;social neuroscience;Social outcome;Social Processes;Source;Stimulus;stress reactivity;theory of mind;Time;Training;translational neuroscience;Translations;young adult

PROJECT_TITLE: Brain-Behavior Mechanisms of Social Cognition in First-Episode Psychosis

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;Immunization;Immunotherapy;Infectious Diseases;Lung;Microbiome;Prevention;Vaccine Related

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE SARS-CoV-2, the virus that causes COVID-19, continues to cause widespread infections associated with unacceptably high mortality. We will use previously collected samples from healthy volunteers inoculated with SARS-CoV-2 in a human challenge study to identify microbes and host immune responses in the upper respiratory tract that modify susceptibility to and symptoms of SARS-CoV-2 infection. These analyses could lead to development of new vaccines or therapies to prevent or treat SARS-CoV-2 infection.

PI_NAMEs: KELLY, MATTHEW SCOTT (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 2019-nCoV;ACE2;Adult;Age Years;Anti-viral Agents;Antibody Therapy;beneficial microorganism;Biological Response Modifier Therapy;Cessation of life;Characteristics;Clinical Data;commensal microbes;Corynebacterium;COVID-19;COVID-19 mortality;COVID-19 susceptibility;COVID-19 treatment;COVID-19 vaccination;COVID-19 vaccine;cytokine;Data;Development;Diagnostic;diaries;differential expression;Education;Etiology;experimental study;first-in-human;Foundations;Future;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Haemophilus influenzae;healthy volunteer;Host Defense;host-microbe interactions;Hour;Human;Immune;Immune response;Immune system;immune system function;Immunity;Immunologics;immunomodulatory therapies;improved;Infection;Infection prevention;Inflammatory;innovation;Integration Host Factors;Interferons;Intranasal Administration;Measures;metagenomic sequencing;Microbe;microbial;microbiome;Modeling;Monoclonal Antibodies;mortality;multiple omics;nasal swab;Nasal turbinate bone structure;Nose;novel;novel therapeutics;novel vaccines;Outcome;pathobiont;pathogen;Pathway interactions;Patient-Focused Outcomes;Patients;Play;Population;Predisposition;prevent;Prevention strategy;Probiotics;rational design;receptor;Recording of previous events;reduce symptoms;Reporting;Research;Resistance;respiratory;respiratory microbiome;respiratory microbiota;respiratory pathogen;Respiratory System;respiratory virus;response;Risk;RNA Helicase;Role;Sampling;SARS-CoV-2 exposure;SARS-CoV-2 infection;Serology;Severities;Shotguns;Site-Directed Mutagenesis;Standardization;Streptococcus pneumoniae;Symptoms;Therapeutic;therapeutic development;TMPRSS2 gene;Toll-like receptors;Transcript;transcriptome;transcriptome sequencing;Up-Regulation;Upper respiratory tract;Vaccination;vaccine development;Vaccines;Viral;Viral Respiratory Tract Infection;Virus

PROJECT_TITLE: Host-microbe interactions and SARS-CoV-2 susceptibility and symptoms in a novel human challenge model

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMII-U(01)]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Women's Health Research

PI_NAMEs: HARRELL, JOSHUA (CHUCK)  (contact)

PROJECT_TERMS: Affect;anti-cancer research;anti-tumor agent;Bioinformatics;black patient;bone;Brain;Breast Cancer Patient;cancer cell;cancer diagnosis;cancer type;Cell Line;Cells;Chemoresistance;chemotherapy;chromosome conformation capture;Clinical Trials;clinically actionable;Collection;Coupling;cytotoxic;Cytotoxic agent;cytotoxicity;Data;data integration;Data Set;Development;Diagnosis;Disease;Disparity;DNA;drug candidate;Drug Combinations;Drug Compounding;Drug Targeting;efficacy evaluation;Endocrine;Environment;ERBB2 gene;Estrogen Receptors;European ancestry;Excision;exhaust;Exhibits;exome sequencing;experience;experimental study;Fostering;Future;Genetic;genome sequencing;Genomics;Goals;Growth;health equity;Hi-C;hormone therapy;Human;In Vitro;in vivo;inhibitor;Injections;insight;interest;Investigational Drugs;Lentivirus;Liver;Luciferases;Lung;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mass Spectrum Analysis;Metastatic breast cancer;Modeling;Neoplasm Metastasis;novel therapeutics;Nuclear Export;Oncogenes;Organ;Organoids;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;phosphoproteomics;Physiology;Pilot Projects;preclinical study;programs;Property;prospective;proteogenomics;Proteomics;receptor;Research Personnel;Research Project Grants;Resistance;Resistance development;response;Sampling;single-cell RNA sequencing;standard of care;Suspensions;Testing;Therapeutic;therapeutic evaluation;therapeutic target;therapy outcome;transcriptome sequencing;transcriptomics;triple-negative invasive breast carcinoma;tumor;tumor growth;whole genome;Woman

PROJECT_TITLE: Research Project 2 Proteogenomic-guided therapeutic targeting of breast cancer patient-derived xenograft metastases


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Child Abuse and Neglect Research;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Prevention;Primary Health Care;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Violence Research;Youth Violence

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Substance abuse is associated with significant individual and social burden. We will leverage two exemplary existing data sources containing both CW (child welfare) and community youth to accelerate knowledge regarding the most important risk factors of early substance use and evaluate the feasibility of translation of the predictive models into a risk score for clinical decision making. This approach, if implemented in clinical care settings, would allow medical providers to more accurately identify those at risk and trigger stratification into different treatment pathways to prevent substance abuse.

PI_NAMEs: DILKINA, BISTRA ;NEGRIFF, SONYA L (contact)

PROGRAM_OFFICER_NAME: VIDAL, SARAH

PROJECT_TERMS: 18 year old;abuse victim;Acceleration;Accidents;addiction;Address;Adolescence;Adolescent;adolescent substance use;Adoption;Adult;African American;Age;alcohol use initiation;California;Caring;Cessation of life;Child;Child Abuse and Neglect;Child Welfare;Childhood;Clinical;clinical care;clinical decision support;clinical decision-making;clinical predictive model;clinical risk;Code;Communities;comparison group;cost;County;Crime;Criminal Justice;critical period;Data;Data Sources;Development;Diagnosis;Disclosure;Documentation;Drug usage;Early Diagnosis;Early identification;Early Intervention;Economics;Electronic Health Record;electronic health record system;Eligibility Determination;ethnic diversity;experience;Family;future implementation;Geography;Health;Healthcare;Healthcare Systems;Homelessness;improved;Income;Individual;Intervention;Knowledge;Latinx;longitudinal dataset;Machine Learning;machine learning method;machine learning model;maltreatment;Maps;marijuana use;Measures;Medical;member;Methods;Modeling;multi-racial;neglect;Neighborhoods;novel strategies;Parents;Participant;Pathway interactions;Persons;Pharmaceutical Preparations;Population;predictive modeling;predictive tools;Predisposition;Prevention;Primary Care;primary care provider;Productivity;Provider;psychosocial;racial diversity;Records;Reporting;Risk;Risk Factors;risk prediction;Sample Size;Sampling;screening;social;Stratification;substance abuse prevention;Substance abuse problem;substance misuse;substance use;Substance Use Disorder;support tools;Surveys;Time;translational potential;Translations;Unemployment;user-friendly;Visit;Vulnerable Populations;Youth

PROJECT_TITLE: Using machine learning to accelerate our understanding of risks for early substance use among child-welfare and community youth

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Immunotherapy;Transplantation

ORG_CITY: BIRMINGHAM

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: The research plan is relevant to public health because it explores a novel pathway that forms an endogenous reactive molecule that acutely attenuates inflammation and could promote immune tolerance. Understanding this pathway could open new therapeutic avenues for limiting auto-immune diseases, attenuating transplant rejection and treating chronic inflammation. Thus, this proposal is significant to the NIH mission in that it seeks to apply fundamental knowledge to enhance health, lengthen life, and reduce illness and disability.

PI_NAMEs: VITTURI, DARIO A (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Acute;adaptive immunity;Address;allograft rejection;Ally;Anti-Inflammatory Agents;Antigen-Presenting Cells;Aryl Hydrocarbon Receptor;Attenuated;Autoimmune Diseases;Autoimmunity;Biological Assay;Cells;chemical synthesis;Chronic;Cysteine;Cytoprotection;Data;Dendritic Cells;design;Development;disability;Endotoxemia;Endotoxins;Energy Metabolism;Exposure to;extracellular;Fostering;Foundations;Generations;Genes;Genetic Transcription;Goals;Graft Rejection;Health;Hepatocyte;Human;Immune;immune activation;Immune response;Immune Tolerance;immunoregulation;in vivo;indoleamine;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;insight;Intervention;Isotopes;Kinetics;knockout animal;Knowledge;Kynurenine;Label;Leukocytes;Life;Ligands;Link;Liver;Macrophage;Malignant Neoplasms;Mediating;Mediator;Metabolic;Metabolism;metabolomics;Mission;Mitochondria;Modeling;Molecular;Mus;Myelogenous;Myeloid Cell Activation;Natural Immunity;novel;novel therapeutics;Organ Transplantation;Outcome;Oxidation-Reduction;Pathway interactions;pharmacologic;Phenotype;polarized cell;programs;Public Health;Publishing;Reaction;Receptor Signaling;Regulation;Regulatory T-Lymphocyte;Reporting;Research;Resistance;Respiration;response;Role;Secondary to;Sepsis;Signal Pathway;Signal Transduction;Solid;Sulfhydryl Compounds;Supplementation;systemic inflammatory response;T cell differentiation;T-Lymphocyte;Testing;TLR4 gene;Toll-like receptors;Tryptophan;Tryptophan Metabolism Pathway;Tryptophanase;United States National Institutes of Health;Up-Regulation;uptake;Work

PROJECT_TITLE: Kynurenine-dependent redox signaling at the interface between innate and adaptive immunity

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Obesity

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative  We wish to understand why people who gain excess weight in the abdomen are more prone to diabetes and high blood fats. The fat tissue under the skin in the abdominal area releases excess fat into the bloodstream, which effects how the rest of our body can metabolize sugars. We are proposing experiments that will measure whether fat cells in leg and abdominal fat are regulated differently in people with excess abdominal fat, and whether this is due to altered functions of certain proteins inside the fat cells.

PI_NAMEs: JENSEN, MICHAEL D. (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Abdomen;abdominal fat;Accounting;Address;Adipocytes;Adipose tissue;Adrenergic Receptor;adult obesity;Antibodies;Area;Biopsy;Blood;Blood Circulation;Blood flow;Blood Vessels;Body Composition;Body fat;Catecholamines;Catheterization;Cells;Central obesity;Control Groups;Data;Diabetes Mellitus;Epinephrine;Esterification;Esterified Fatty Acids;Event;excessive weight gain;Exercise;experimental study;Fasting;Fatty acid glycerol esters;fatty acid metabolism;Fatty Acids;femoral artery;Femoral vein;flexibility;Functional disorder;glucose disposal;Glycerol;Goals;Health;hepatic vein;Heterogeneity;Human;Hydrolysis;Hyperinsulinism;Impairment;in vivo;Inflammation;Infusion procedures;insight;Insulin;Insulin Resistance;insulin secretion;Insulin Signaling Pathway;interest;Intravenous;Isotopes;Knowledge;Leg;Link;Lipids;Lipolysis;Liver;Mass Spectrum Analysis;Measures;Metabolic;Morphology;Muscle;Nicotinic Acids;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;Obesity;Pathway interactions;perilipin;Persons;phosphoproteomics;Phosphorylation;Phosphorylation Site;Plasma;Post-Translational Protein Processing;Process;Protein Dephosphorylation;Proteins;regional difference;Regulation;Regulatory Pathway;Reporting;Research Personnel;Resistance;response;Rest;Sampling;sex;Skin;Somatostatin;Source;Stimulus;Structure;subcutaneous;sugar;Testing;Therapeutic;Tissues;Tracer;Triglycerides;Visceral;Visceral fat

PROJECT_TITLE: FFA Metabolism in Different Types of Human Obesity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-L(02)M]


ADMINISTERING_IC: MD

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE Approximately 193,000 Latino immigrants without green cards in California recently avoided Medicaid enrollment, despite the Biden administration’s reversal of the immigration public charge rule definition in 2021 and their eligibility for Medicaid in the state, likely because of fears about their citizenship and immigration statuses. This study will use three different but complementary sources of qualitative and quantitative data to study mis- and disinformation among Latinos regarding immigration policies, including their relationships with chilling effects in Medicaid enrollment and health care access and utilization.

PI_NAMEs: BUSTAMANTE, ARTURO VARGAS;ORTEGA, ALEXANDER N (contact)

PROGRAM_OFFICER_NAME: JONES, NANCY LYNNE

PROJECT_TERMS: Adult;Age;Age Years;Attitude;Authorization documentation;California;care seeking;Charge;Chills;Communication;Communities;community organizations;Confusion;Consumption;Country;Data;Decision Making;design;disinformation;distrust;Documentation;Eligibility Determination;Enrollment;Ethnic Origin;Ethnic Population;Etiology;Exercise;follow-up;Follow-Up Studies;Fright;Funding;Government;Green Card;Health;health care availability;health care disparity;Health Care Seeking Behavior;health care service utilization;health organization;Health Services Accessibility;Healthcare;Home;Housing;Human Rights;Immigrant;Immigration;Income;Inequity;informant;Infrastructure;insight;Institution;Interview;Knowledge;Latino;Latino Population;Laws;Legal;Legal Status;Life;Link;Machine Learning;Medicaid;Medicaid eligibility;Medicare;Methods;Mexican;Misinformation;National Institute on Minority Health and Health Disparities;nutrition;Pattern;Perception;Persons;Policies;Politics;Population;programs;Race;racial population;Research;Residencies;Resources;Rights;safety net;Site;social;social health determinants;social media;Social Security;Source;Structure;Surveys;Taxes;Time;Trust;United States;welfare;Work

PROJECT_TITLE: Understanding Mis- and Disinformation About Health Care Access and Their Impacts on Decision-Making Among Latino Immigrants


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: Newark

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE In response to the tobacco industry’s campaign about the exacerbation of police brutality to African Americans, scientists are calling for communication research that addresses the industry’s disinformation and corrects misperceptions about menthol cigarettes and flavored cigars. Our proposed study will develop a multi-level anti- disinformation message (ADM) campaign using a health equity lens. We will provide evidence of the effectiveness of the ADM campaign messages on flavor ban receptivity and tobacco industry beliefs among African Americans.

PI_NAMEs: STERLING, KYMBERLE L (contact);VILLANTI, ANDREA

PROGRAM_OFFICER_NAME: GILLMAN, ARIELLE SAMANTHA

PROJECT_TERMS: Address;Adult;African American;African American population;Age;American;Area;Attitude;Awareness;Behavior;Behavioral;Belief;Black Bear;Black Populations;Cessation of life;Cigar;Cigarette;cigarillos;Cities;Communication;Communication Research;Communities;community based participatory research;Creativeness;Criminal Justice;Data;Decision Making;design;Development;Discrimination;disinformation;distrust;Effectiveness;effectiveness evaluation;effectiveness testing;efficacy testing;Electronic Mail;Enrollment;Environmental Risk Factor;Evaluation;Event;evidence base;experience;Flavoring;Focus Groups;Future;Government;Health;health disparity;health equity;Heart Diseases;Individual;Industry;informant;innovation;Intention;Intervention;intervention mapping;Interview;Knowledge;Lobbying;Logic;Malignant Neoplasms;Marketing;member;Menthol;Methodology;Misinformation;Modeling;Movement;Neighborhoods;news;Participant;peer;Perception;Planning Theory;Police;Politics;Privatization;Process;Protocols documentation;psychosocial;Public Health;public policy on tobacco;Publishing;Randomized;Recording of previous events;Research;Research Methodology;research study;Respondent;response;Risk Factors;Role;Sales;Sampling;Science;Scientist;shared decision making;Smoker;Smoking;Source;Structural Racism;Surveys;System;Testing;theories;therapy design;therapy development;Tobacco;tobacco advertising;tobacco flavor;Tobacco Industry;tobacco products;Tobacco use;trial design;Trust;United States Food and Drug Administration;Vulnerable Populations;Work;Youth

PROJECT_TITLE: The Unvarnished Truth: Pursuing Health Equity by Correcting Disinformation Targeting African Americans about the FDA's Proposed Ban on Menthol Cigarettes and Flavored Cigars


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Project Narrative Increasing energy expenditure is a promising strategy for treating obesity and metabolic diseases; however, a compensatory increase in food intake could dampen its benefits. We will use cold and thermogenesis-induced feeding in rodents as a model to investigate the neural mechanisms underlying the compensatory energy intake. This project aims to provide insight into how to effectively modulate energy homeostasis at the whole organismal level to battle metabolic diseases.

PI_NAMEs: YE, LI  (contact)

PROGRAM_OFFICER_NAME: LAUGHLIN, MAREN R

PROJECT_TERMS: Acute;Affect;Agreement;Anatomy;Animals;Automobile Driving;Behavior;Behavioral;Behavioral Model;Biological Assay;Body Temperature;Brain;Calorimetry;Cell Nucleus;Collaborations;Compensation;Costs and Benefits;Couples;Coupling;Data;Eating;energy balance;Energy Intake;Energy Metabolism;Esthesia;Etiology;Exercise;Expenditure;Fasting;Fatty acid glycerol esters;Feedback;feeding;Feeding behaviors;Fiber;Food;FOS gene;Foundations;Future;gain of function;Genetic;genetic approach;Goals;Homeostasis;Human;Hypothalamic structure;Image;in vivo;in vivo calcium imaging;insight;Intervention;Light;Limbic System;loss of function;Mammals;Maps;Measures;Mediating;Metabolic;Metabolic Diseases;Metabolism;Midline Thalamic Nuclei;Modeling;Molecular Target;Natural Increases;neural;neuromechanism;Neurons;Non-Insulin-Dependent Diabetes Mellitus;Obesity;optogenetics;Output;Pathway interactions;pharmacologic;Photometry;Physiological;Public Health;recruit;Regulation;Research;Rewards;Rodent;Role;screening;Signal Transduction;System;Techniques;Thalamic structure;Thermogenesis

PROJECT_TITLE: Neural Mechanisms of Energy Expenditure-Induced Compensatory Food Intake

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Congenital Structural Anomalies;Dementia;Genetics;Headaches;Neurodegenerative;Neurosciences;Pain Research;Pediatric;Prevention;Rare Diseases;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE This project is relevant to public health because Marfan syndrome (MFS), a disease of accelerated aging, and cerebrovascular aging are risk factors for cerebrovascular disease and potentially an increased risk for vascular cognitive impairment and dementia. The proposed experiments will be the first to measure the influence of an MFS-associated fibrillin-1 mutation’s accompanying signaling cascades on cerebrovascular pathology, neuropathology, neurotransmission, and neurobehavioral alterations and evaluate sex as a biological variable. Knowledge gained will improve mechanistic understanding behind cerebrovascular aging associated with neurological alterations and potentially provide novel therapeutic targets to attenuate the impact of aging on brain function, where biological sex differences would promote the need for personalized medicine based on sex.

PI_NAMEs: CURRY-KOSKI, TALA  (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Age;age acceleration;Age Months;aged;Aging;aging population;aging related;Aneurysm;Aorta;arterial stiffness;Arteries;Attention deficit hyperactivity disorder;Attenuated;autosome;Behavior;Binding;Biological Assay;biological sex;Blood - brain barrier anatomy;Blood capillaries;Blood Vessels;blood-brain barrier permeabilization;bone;Brain;Brain region;Breeding;C57BL/6 Mouse;Cerebral Aneurysm;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;cerebrovascular pathology;Cerebrovascular system;comparison control;Connective Tissue Diseases;cytokine;Data;dementia risk;Disease;Dissection;Elasticity;Elastin;Elastin Fiber;endothelial dysfunction;Endothelium;ethnic bias;experimental study;Extracellular Matrix;Extravasation;FBN1;Female;fluid percussion injury;Frequencies;Functional disorder;Genes;Genetic;glial activation;Glutamates;Goals;Headache;Heritability;high risk;Hippocampus;Hypertrophy;Immunohistochemistry;Impairment;improved;in vivo;Incidence;Individual;Induced Mutation;Inflammation;Inflammatory;inflammatory marker;interest;Investigation;Kinetics;Knowledge;Life;Location;male;Marfan Syndrome;Matrix Metalloproteinases;Measures;Mediating;Mentors;Microelectrodes;Microglia;middle cerebral artery;Migraine;mild traumatic brain injury;MMP2 gene;MMP9 gene;Modeling;Molecular;Morphology;mouse model;Mus;Muscle;Mutate;Mutation;neurobehavioral;Neurologic;Neurologic Deficit;neuropathology;neurotransmission;new therapeutic target;normal aging;novel;Outcome;Pathway interactions;patient population;Patients;Peripheral;personalized medicine;Plasma;Play;pre-clinical;preservation;prevent;Prevention;Production;Proteins;Public Health;Publications;Quality of life;Randomized;Rattus;Regional Perfusion;Reporting;Research;Resources;Risk;Risk Factors;Role;Rupture;scaffold;Severities;sex;sex as a biological variable;Sex Bias;Sex Differences;Signal Pathway;Signal Transduction;Signaling Molecule;Stroke;Structure;Structure of choroid plexus;Structure of posterior cerebral artery;Testing;TGFB1 gene;therapeutic target;Transforming Growth Factor beta;Ultrasonography;vascular cognitive impairment and dementia;Vascular Diseases;Wild Type Mouse

PROJECT_TITLE: Accelerated Cerebrovascular Aging in a Fibrillin-1 Mutated Mouse Model

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


NIH_SPENDING_CATS: Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: Project Narrative Human stem cell-derived neurons show immature properties characteristic of fetal rather than adult nervous system cells, which limits their use for applications in modeling human disease or in regenerative medicine. Here, we will study the molecular factors that control the pace of human neuronal maturation, establish novel assays to precisely measure maturation in a dish and develop strategies that accelerate the maturation process. This project addresses a major bottleneck in human stem biology and should result in better tools to study neurodevelopmental and neurodegenerative disorders in the future.

PI_NAMEs: STUDER, LORENZ P. (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Adopted;Adult;Astrocytes;Automobile Driving;Basic Science;Behavior;Biological Assay;Biology;Birth;Brain;Cell Maturation;cell motility;cell type;Cells;Characteristics;Chemicals;Chromatin;Complex;Conceptions;Data;Development;Developmental Process;differentiation protocol;directed differentiation;Disease;disease model;Embryo;Epigenetic Process;excitatory neuron;Exhibits;fetal;Fingerprint;Future;Genes;Genetic;genetic approach;Goals;Human;Human Characteristics;Human Development;human disease;human induced pluripotent stem cells;human model;human pluripotent stem cell;human stem cell-derived;improved;in utero transplantation;In Vitro;in vivo;inhibitory neuron;Intrinsic factor;Link;Measures;Microglia;Modeling;Molecular;Molecular Profiling;Mus;nerve stem cell;Nervous System;neural;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neuroglia;neuron development;Neuronal Differentiation;Neurons;neuropsychiatric disorder;novel;Organoids;pharmacologic;pluripotent stem cell differentiation;predictive marker;prevent;Process;programs;Property;Protocols documentation;Regenerative Medicine;Reporter;Research Personnel;Role;stem;stem cell differentiation;stem cells;Study models;System;Testing;three dimensional cell culture;timeline;tool;Transplantation;Work;Xenograft procedure

PROJECT_TITLE: Cell Intrinsic and Extrinsic Factors Driving Maturation in Human PSC-derived Neurons

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Characterization of the transcriptional co-activator Yes-Associated Protein (YAP) and its paralog WW-domain containing Transcriptional co-Activator with PDZ-binding motif (TAZ), two central effectors of the Hippo pathway, as downstream points of convergence in the signaling cascade initiated by anti-donor HLA antibodies (Ab) will permit us to establish mechanisms underlying how HLA Ab promote endothelial cell (EC) growth contributing to chronic antibody-mediated rejection (cAMR). We will also determine if FDA-approved drugs of the statin family inhibit YAP function in HLA Ab-activated ECs providing evidence that drugs of the statin family can be an important element in preventing cAMR via blocking growth-promoting YAP/TAZ signaling in ECs.

PI_NAMEs: FAIRCHILD, ROBERT L;REED, ELAINE F (contact);ROZENGURT, JUAN ENRIQUE

PROGRAM_OFFICER_NAME: KULKARNI, SHILPA S

PROJECT_TERMS: Actins;Allografting;Antibodies;antibody-mediated rejection;Blood Vessels;cell growth;cell motility;Cell Proliferation;Cell Transplantation;Cells;Characteristics;Chronic;Clinical;Clinical Trials;crosslink;Dasatinib;Development;donor-specific antibody;Drug usage;Elements;Endothelial Cells;epidemiology study;Evolution;Exhibits;Family;FDA approved;Funding;Genetic Transcription;Grant;Growth;heart allograft;Heart Transplantation;Human;in vivo;inhibitor;Injury;Lesion;Ligation;Mediating;migration;Modeling;Molecular;novel;Oncology;Organ;organ transplant recipient;organ transplant rejection;Organ Transplantation;paralogous gene;Pathogenesis;Pathway interactions;Perivascular Fibrosis;Pharmaceutical Preparations;Phosphorylation;PI3K/AKT;Play;Population;Positioning Attribute;prevent;Prevention;Process;programs;Proliferating;protein function;Proteins;PTK2 gene;Regulation;response;rho;Risk;Role;Serine;Signal Induction;Signal Pathway;Signal Transduction;Solid;src-Family Kinases;Surface;Testing;Therapeutic;therapeutic target;therapeutically effective;Transcription Coactivator;transcription factor;Transcriptional Coactivator with PDZ-Binding Motif;Transplantation;Tyrosine;Tyrosine Phosphorylation;Vascular Diseases

PROJECT_TITLE: Targeting the transcriptional co-activators YAP and TAZ with statins to prevent solid organ transplant rejection by HLA donor specific antibodies

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: PISCATAWAY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

PHR: Project Narrative This K01 Mentored Research Scientist Development Award will partner with a Community Advisory Board to develop and pilot a community-based, theory-guided mental health literacy intervention for Black/African American young adults. Post-study focus groups with intervention participants will be held to elicit feedback on relevance, feasibility, acceptability, and satisfaction with the intervention to inform refinement and future dissemination efforts. The potential public health impact is large, as Black/African American young adults have low likelihood of engaging in mental health treatment despite elevated risk for exposure to trauma, subsequent mental health concerns (e.g., PTSD, substance use), and poor outcomes from untreated mental health conditions—particularly given the myriad psychological and emotional impacts of the Covid-19 pandemic.

PI_NAMEs: BAUER, ALEXANDRIA GABRIELLE (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Adult;African American;Age;aged;Alcohol consumption;American;Area;Attitude;barrier to care;Baseline Surveys;Behavior;Behavioral;behavioral construct;behavioral outcome;Belief;Black race;care burden;career;career development;Church;Clinical;college;Communities;community advisory board;community based research;community building;community collaboration;community engaged research;community engagement;community organizations;community setting;Complex;coping;Counseling;COVID-19 pandemic;COVID-19 pandemic effects;culturally appropriate intervention;design;Development;Dimensions;Disparity;Educational Curriculum;Educational Materials;Educational workshop;Elements;Emotional;emotional distress;Ensure;Equity;European;experience;Feedback;Focus Groups;Fostering;Future;Gender;Goals;graduate school;Hair;Health;health care service utilization;health literacy;Healthcare Systems;Hispanic;improved;Individual;Intervention;intervention participants;intervention refinement;Knowledge;Learning;member;men;Mental Depression;mental development;Mental disorders;Mental Health;Mental health promotion;Mental Health Services;Mentored Research Scientist Development Award;Mentors;Mentorship;Methods;minority communities;Modeling;Outcome;Participant;peer;Perception;Planning Theory;Positioning Attribute;post intervention;Post-Traumatic Stress Disorders;prevent;Prevention;primary outcome;professor;Provider;psychoeducation;psychologic;psychological distress;Psychologist;Psychology;psychosocial;Public Health;racial disparity;Recording of previous events;Recovery Support;recruit;Research;Research Assistant;Research Methodology;Research Personnel;Resources;Risk;Sampling;satisfaction;Schools;secondary outcome;Services;Signs and Symptoms;Site;social;social stigma;Socioeconomic Status;substance use;Substance Use Disorder;substance use treatment;symptom management;Symptoms;tenure track;theories;therapy design;Translational Research;Trauma;trauma exposure;trend;Underrepresented Students;underserved community;Universities;university student;Woman;Writing;young adult

PROJECT_TITLE: Building a Community-Based Mental Health Literacy Intervention for African American Young Adults

STUDY_SECTION: EMHI

STUDY_SECTION_NAME: Effectiveness of Mental Health Interventions Study Section[EMHI]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences;Sleep Research

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: NARRATIVE There are a wide array of negative outcomes associated with sleep disturbance (in general) and insomnia (in specific) including fatigue, cognitive impairment, mood disturbance, impaired daytime function, and diminished quality of life. Beyond these regular daytime effects, sleep disturbance substantially increases the risk for depression, substance abuse, hypertension cardiovascular disease, glucose homeostasis dysregulation, immuno-suppression, overall increased health care utilization, and possibly increased mortality. These associations clearly suggest that there is an urgent need to better characterize sleep disorders symptoms in terms of how they develop and how are expressed over time, both in general, and specifically in the most vulnerable of populations: older adults.

PI_NAMEs: PERLIS, MICHAEL LLOYD (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Achievement;Acute;Adult;affective disturbance;Age;age difference;age effect;age related;Aging;Alzheimer's disease patient;Archives;Area;Arizona;Award;Behavioral;beneficiary;Benefits and Risks;biopsychosocial;blood glucose regulation;Books;Cardiovascular Diseases;career;Cellular Phone;Chronic;Chronic Insomnia;Chronobiology;Clinical;Clinical Services;cohort;Collaborations;commercial application;cost;Data;data archive;data de-identification;data integration;data portal;Data Set;Data Sources;Databases;Dedications;Development;digital;diverse data;Dose;Education;Educational process of instructing;Environment;epidemiology study;Exhibits;expectation;experience;Fatigue;follow-up;Foundations;Frustration;Funding;Future;Generations;Geography;Goals;Grant;Hand;health care service utilization;Hypertension;hypnotic;Immunosuppression;Impaired cognition;Impairment;Incidence;indexing;Individual;Industry;instrument;Internet;Investigation;Learning;lectures;life span;Longitudinal Studies;Maintenance;Mediating;Medical;medical specialties;Medicine;Mental Depression;Mentors;Mentorship;Meta-Analysis;Mid-Career Clinical Scientist Award (K24);middle age;Morbidity - disease rate;mortality;multiple datasets;Natural History;older adult;Online Systems;Outcome;Paper;Parkinson Disease;patient oriented;patient oriented research;Patient Self-Report;Patients;Peer Review;Pennsylvania;Pharmaceutical Preparations;Pilot Projects;Placebo Effect;Placebos;Prevalence;programs;Psychiatry;Psychological reinforcement;Public Health;Quality of life;Recovery;recruit;Regimen;Relapse;Reporting;Research;Research Personnel;response;Risk;Running;Scientist;screening;Secure;Series;Services;Severity of illness;Sleep;Sleep Disorders;Sleep disturbances;sleep health;Sleeplessness;smart speaker;Source;Substance abuse problem;Summary Reports;Surveys;symposium;symptom cluster;Symptoms;System;Text;Time;Training;treatment response;Universities;Vulnerable Populations;Work;zolpidem

PROJECT_TITLE: Behavioral Sleep Medicine: Training in Sleep and Aging

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


PHR: PROJECT NARRATIVE: It is increasingly appreciated that multicellular interactions between the peripheral nervous system and immune cells drive the pathogenesis of chronic inflammatory diseases, and that understanding these interactions represents a major milestone toward developing effective treatments for these highly prevalent and debilitating disorders. The goal of this proposal is to determine how peripheral sensory neurons influence the pathogenesis of inflammatory diseases of the skin and visceral organs. This research will provide a basic understanding into the role of neuroimmune crosstalk in inflammation and inform the development of novel therapeutics for chronic inflammatory diseases.

PI_NAMEs: HILL, ROSE Z (contact)

PROGRAM_OFFICER_NAME: SYPEK, ELIZABETH IRENE

PROJECT_TERMS: Ablation;Address;Adolescent;Afferent Neurons;Agonist;American;Animals;Award;Back;Bacterial Gastritis;Behavior;Behavioral;Body System;candidate identification;career development;Cells;Chemicals;Chronic;chronic inflammatory disease;chronic itch;combat;conditional knockout;Cues;Cutaneous;Data;Data Set;Dedications;detection platform;Development;Disease;Dissociation;effective therapy;Electrophysiology (science);experimental study;Functional disorder;Future;Gastritis;Gastrointestinal tract structure;Gastrointestinal Transit;Gene Expression;Genetic;genetic approach;Genetic Models;Genetic Transcription;Goals;Health;Histologic;Histology;Human;Hypersensitivity;Immune;immune cell infiltrate;Immune response;Immune system;Immunologics;immunoregulation;improved;Inflammation;Inflammatory;Inflammatory Response;innovation;insight;Interleukin-4;Interleukins;Knockout Mice;Knowledge;Label;Lead;Learning;Leukotriene C4;Lipids;Maps;Measures;mechanical signal;mechanical stimulus;Mechanics;Mediating;Mediator;Mentors;Modeling;Molecular;mouse model;Mus;Nature;nerve supply;Nervous System;Neuroimmune;neuronal excitability;neuronal patterning;Neurons;Neuropeptides;novel;novel therapeutics;Organ;Pathogenesis;Pathway interactions;Patients;Pattern;Peripheral;Peripheral Nervous System;Phase;Physiological;Physiology;Piezo 1 ion channel;Play;Positioning Attribute;programs;Pruritus;Publishing;Pylorus;receptor;Receptor Activation;Reporter;Research;Research Institute;Role;sensor;Sensory Ganglia;Signal Pathway;Signal Transduction;Skin;skin disorder;Sphingosine-1-Phosphate Receptor;Spinal;Stimulus;Stomach;symposium;Techniques;Testing;Tissues;tool;Training;transcriptome sequencing;transcriptomics;Translating;translational potential;Validation;Viral;Visceral;Work

PROJECT_TITLE: Functional interrogation of sensory neurons in inflammation

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Human blood eosinophil (EOS) counts correlate with left ventricle mass and ventricular wall and interventricular septum thickness. Our recent published work suggests a cardioprotective role for EOS in pressure overload-induced cardiac hypertrophy and heart failure by releasing type-2 cytokines and cationic proteins. This plan is proposed to study the role of EOS cationic proteins in protecting cardiomyocytes and cardiac fibroblasts from pressure overload-induced cardiac hypertrophy and heart failure using different sets of bone morphogenetic protein receptors.

PI_NAMEs: LIBBY, PETER  (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: Adoptive Transfer;Adrenergic beta-Agonists;Agonist;aorta constriction;Apoptosis;Basic Science;Biological Markers;Blood;BMPR1A gene;Bone Marrow;bone morphogenetic protein receptors;Cardiac;Cardiac Myocytes;cardioprotection;Cardiovascular Diseases;cardiovascular disorder risk;Cause of Death;Cells;chemokine;Clinical Research;Coronary heart disease;cytokine;Cytoplasmic Granules;Diphtheria Toxin;eosinophil;Eosinophil cationic protein;Event;Female;Fibroblasts;Fibrosis;gain of function;GATA1 gene;granule cell;Growth Factor;Heart;Heart Block;Heart failure;Heart Hypertrophy;Human;human disease;Hypertension;Hypertrophy;IL4 gene;indexing;Inflammation;Infusion procedures;Injury;Isoproterenol;Left Ventricular Mass;Left ventricular structure;Lipids;loss of function;Maintenance;male;MAP Kinase Gene;MAPK8 gene;Measures;Molecular;mortality;Mus;p38 Mitogen Activated Protein Kinase;Pathogenesis;Pathway interactions;Patients;Phenotype;PIK3CG gene;pressure;Prevalence;prevent;protein expression;Proteins;Publishing;receptor;repaired;Reporting;Residual state;Risk;Risk Factors;Role;SARS-CoV-2 infection;Signal Transduction;Site;success;Testing;Thick;Transcriptional Regulation;Transforming Growth Factor beta;Ventricular;Ventricular septum;Work

PROJECT_TITLE: Role of eosinophil cationic proteins in cardiac hypertrophy

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

PHR: NARRATIVE This study investigates a new source of innate lymphoid cells (ILCs) that are known to modulate immune reactions. We have shown that ILCs can be made not only in the bone marrow but also in the thymus, which may generate ILCs with different functionality. Because only children have an active thymus, the ILCs they produce may help explain the different immune reactions between children and adults.

PI_NAMEs: SUN, XIAO-HONG  (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Adult;Age;age difference;age related;Agonist;Allergic;Amphiregulin;Behavior;Biological;Biological Assay;Blood;Bone Marrow;CD3 Antigens;CD8B1 gene;Cell Differentiation process;Cell Physiology;Cells;Child;Classification;Cues;cytokine;Cytoplasm;Development;developmental immunology;differentiation in vitro;Down-Regulation;E protein;Event;Frequencies;Gene Rearrangement;Generations;Genetic Recombination;germ free condition;Germ-Free;gut microbiota;helminth infection;Home;House mice;IL17 gene;IL7R gene;Immune;Immune response;Immunity;immunoreaction;immunoregulation;In Vitro;in vitro testing;Infection;Interleukin-1 beta;Interleukin-13;interleukin-22;interleukin-23;Interleukin-5;Knockout Mice;Learning;Lung;Lymphoid Cell;Measures;microbiota;Monitor;Mus;Natural Killer Cells;Neuropeptides;Newborn Infant;novel;Nude Mice;Nutrient;old mice;Only Child;Output;pathogen;Peripheral;Phenotype;Play;Population;Population Heterogeneity;Production;Proliferating;Property;protective factors;protein function;Proteins;Regulation;Reporting;response;Role;Salmonella;SELL gene;Sentinel;Signal Transduction;single-cell RNA sequencing;Small Intestines;Source;Stimulus;Stromal Cells;Surface;T-Cell Development;T-Cell Receptor Genes;T-Lymphocyte;Testing;thymocyte;Thymus Gland;Tissues;Toxoplasma;Weaning;γδ T cells

PROJECT_TITLE: γδTCR-dependent and independent differentiation of innate lymphoid cells

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_NAME: GERONTOLOGICAL SOCIETY OF AMERICA

ORG_STATE: DC

PHR: Project Narrative Aging is a complex issue that must not be viewed from a single lens. Older adults have the most to lose when the expertise of scientists from diverse backgrounds is absent and the most to gain from an approach that brings all perspectives to bear. The RCMAR National Coordinating Center addresses this issue by developing tools to support new researchers from diverse backgrounds and supporting a network of researchers in making scientific discoveries that eliminate health disparities and improve the health and well-being of older adults.

PI_NAMEs: BAKER, TAMARA A;BARNES, LISA L;D'ANTONIO, PATRICIA M (contact);SCEPPA, CARMEN CASTANEDA

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Address;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Awareness;Behavioral;behavioral and social science;behavioral study;career;career development;clinical practice;Collaborations;Communities;Community Participation;Complex;Consensus;Data;Development;Discipline;editorial;Education;Educational workshop;Environment;equity, diversity, and inclusion;Evaluation;evidence base;Family;Feedback;Fostering;Gerontology;Goals;Grant;Growth;Health;health disparity;Hispanic-serving Institution;Historically Black Colleges and Universities;improved;informant;Infrastructure;innovation;Institution;Interest Group;Interview;Journals;leadership development;Learning;lens;Literature;Manuscripts;meetings;member;Mentors;Mentorship;Minority;Minority Groups;minority student;Minority-Serving Institution;Mission;multidisciplinary;older adult;Peer Review;Personal Satisfaction;Persons;Play;podcast;Policies;Process;Professional Organizations;programs;Publishing;Race;racial minority;Reporting;Research;research data dissemination;Research Personnel;Resource Sharing;Resources;Role;Scholarship;Scientist;skills;social;Societies;socioeconomics;Strategic Planning;tool;Training;tribal college;Underrepresented Minority;virtual;web site;webinar;Work;Writing

PROJECT_TITLE: Resource Centers for Minority Aging Research National Coordinating Center (RCMARs NCC)


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Cancer;Genetics;Skin Cancer

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE Much of the human head is formed from neural crest cells and abnormalities during neural crest cell development can lead to congenital craniofacial and neurological defects and cancers including melanoma. Preliminary data suggests that the precise location of RNAs within individual neural crest cells or their derivatives can affect behavior of the cell. This project will elucidate the fundamental principles regulating the location and function of these RNAs within cells, and causally link RNA localization to developmental and cancer-related outcomes.

PI_NAMEs: NORRIS, MEGAN L (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Address;Advisory Committees;Affect;Attention;Award;Biological Assay;cancer genetics;career;Catalogs;cell behavior;cell motility;Cell Physiology;cell type;Cells;Co-Immunoprecipitations;collaborative environment;Congenital Abnormality;craniofacial;Data;Defect;design;Development;Diagnosis;Disease;Elements;Embryonic Development;Environment;experience;experimental study;falls;gain of function mutation;Galium;Genes;Genetic Engineering;Genetic Transcription;Goals;Head;Human;Image Analysis;In Vitro;in vivo;Individual;insight;interest;Intervention;Invaded;Kinesin;light microscopy;Link;Location;loss of function;Malignant Neoplasms;Mammalian Cell;melanocyte;Melanoma;Melanoma Cell;Mentorship;Messenger RNA;migration;Modeling;Molecular;Motor;mouse model;Mus;Mutation;Neural Crest;Neural Crest Cell;Neurologic;Neurons;novel;Outcome;Pathway interactions;Phenotype;Physiological;Physiology;Post-Transcriptional Regulation;posttranscriptional;Prevention;Process;programs;protein function;protein protein interaction;Proteins;Regulation;Research;Resources;RNA;Role;Route;Running;Schwann Cells;single molecule;System;Techniques;Technology;Testing;Time;Tissues;Total Internal Reflection Fluorescent;trafficking;Training;Trans-Activators;Transcription Process;transcriptomics;Translations;tumor progression

PROJECT_TITLE: Regulation and function of subcellular RNA localization in neural crest cells and their derivatives

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Immunotherapy;Microbiome;Nutrition;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: NARRATIVE Changes in the gut microbiota have been associated with many diseases, but causal inference is often lacking. Preclinical and clinical studies have demonstrated that the intestinal microbiota can regulate innate and adaptive immunity, including T cell and antitumor immunity after allogeneic hematopoietic cell transplantation and checkpoint blockade. The goal of our research is to target the intestinal microbiota to improve cancer immunotherapy, which has tremendous potential to improve the lives of patients being treated for cancer.

PI_NAMEs: VAN DEN BRINK, MARCEL R M (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Abate;adaptive immunity;Allogenic;Animals;Antibiotics;Autologous;beneficial microorganism;Bile Acids;cancer immunotherapy;CAR T cell therapy;chimeric antigen receptor T cells;Clinical;clinical development;Clinical Research;Clinical Trials;commensal microbes;Communities;computational platform;Data;data harmonization;Development;Diet;Disease;Enterococcus;Exposure to;fecal transplantation;Funding;Future;Goals;graft vs host disease;gut microbiome;gut microbiota;Hematopoietic;Hematopoietic Stem Cell Transplantation;Human;immune checkpoint blockade;Immunity;Immunology;immunoregulation;Immunotherapy;improved;insight;Investigation;Machine Learning;Malignant Neoplasms;Microbe;microbiome;microbiome analysis;microbiome composition;microbiota;microbiota composition;Modality;mortality;multiple omics;Mus;Natural Immunity;novel;Oncology;Outcome;Patients;Pharmaceutical Preparations;Physiology;pre-clinical;preclinical study;reconstitution;Research;Role;stool sample;T-Lymphocyte;Techniques;therapeutic evaluation;Toxic effect;Translating;tumor;Tumor Immunity;Work

PROJECT_TITLE: The role of the intestinal microbiome in cancer immunotherapy


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: BATON ROUGE

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: PROJECT NARRATIVE Reciprocal connections between the ventral tegmental area (VTA), a midbrain nucleus, and the hippocampus (CA1) form a loop that governs novelty and discrimination between contexts based on their relevance. Although the VTA contains several neuron types that innervate the hippocampus, the functions of the VTA in the loop have been primarily attributed to its dopamine neurons. The traditional focus on the dopamine pathway significantly limits our understanding of the anatomically dominant VTA glutamate projections in the hippocampus. Thus, the proposed project will use a multi-method approach to dissect the role of the VTA glutamate-CA1 tract in hippocampal encoding and expression of novelty-dependent behaviors.

PI_NAMEs: OGUNDELE, OLALEKAN MICHAEL (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Adaptive Behaviors;addiction;Anatomy;Architecture;Area;autism spectrum disorder;Behavior;behavioral phenotyping;Bipolar Depression;Brain;Brain region;Cell Nucleus;Cells;Cognitive;cognitive control;cognitive process;Dendrites;Desire for food;Detection;Discrimination;Disease;Dopamine;dopaminergic neuron;Electrophysiology (science);experimental study;Extinction;Food;Frequencies;Future;gamma-Aminobutyric Acid;Glutamates;Goals;habituation;Hallucinations;Hippocampus;in vivo;Interneurons;Knowledge;learned behavior;Learning;Link;Medial;Memory;Mental Depression;Methods;Midbrain structure;Mus;Nature;neural;neural circuit;Neurons;neuropsychiatric disorder;Neurotransmitters;Noise;novel;optogenetics;Pathway interactions;Pattern;Physiological;Positive Valence;Prefrontal Cortex;Pyramidal Cells;Research;Rewards;Role;Schizophrenia;social;social contact;Stimulus;System;Ventral Tegmental Area

PROJECT_TITLE: The role of excitatory VTA projections in novelty-dependent behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-P(57)]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Mental Health;Pediatric;Prevention;Rural Health;Social Determinants of Health;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: EUGENE

ORG_NAME: SAAVSUS, INC.

ORG_STATE: OR

PHR: Project Narrative  Reducing and preventing child bullying and victimization has become a national priority for improving safety in schools and the health and educational outcomes for children. The proposed project seeks to complete the adaption of the current 40-hour in-person radKIDS® instructor training (begun in Phase I) into a blended, multimedia in-person/online format to promote child safety from victimization and test the effectiveness of the program with a diverse school-based sample in a clustered randomized trial.

PI_NAMEs: JOHNSON-SHELTON, DEBORAH  (contact)

PROGRAM_OFFICER_NAME: HUELSNITZ, CHLOE OLIVIA

PROJECT_TERMS: Absenteeism;Address;Administrator;Adolescence;Adoption;Adult;Age;aged;American;Assertiveness;Behavior;Benchmarking;bullying;bullying prevention;California;Caregiver Burden;Child;child and adolescent victimization;Childhood;Cluster randomized trial;commercial application;Communication;Communities;Consumer Satisfaction;Coping Skills;COVID-19 pandemic;Critical Thinking;Development;Distance Learning;Distress;Education;Educational Curriculum;effectiveness testing;elementary school;Emotional;empowerment;Evaluation;Evidence based program;experience;externalizing behavior;Family;field study;flexibility;fourth grade;Geography;Goals;Growth;Guidelines;Health;help-seeking behavior;Hour;implementation fidelity;improved;Incidence;Injury;Instruction;instructor;Intervention;Interview;Knowledge;Learning;Learning Module;Link;Low income;Marketing;Measurement;Measures;member;Minority;minority student;multidisciplinary;Multimedia;Oregon;Outcome;pandemic disease;Parents;peer victimization;Persons;Phase;phase 2 study;post-pandemic;prevent;Prevention;Prevention program;Privatization;Program Acceptability;Program Effectiveness;programs;Psychoses;psychosocial stressors;Public Health;Randomized;Recommendation;Reporting;response;Risk;Rural;Safety;safety education;Sampling;satisfaction;School Drop-Outs;Schools;Self Efficacy;self esteem;Sexual abuse;skills;skills training;Small Business Innovation Research Grant;social;Student Dropouts;Students;Substance abuse problem;System;Teacher Professional Development;Teenagers;Texas;trafficking;Training;Training Programs;traumatized children;usability;Utah;Victimization;Violence;violence prevention

PROJECT_TITLE: Development and evaluation of a multi-media training program for elementary school bullying and abuse prevention: radKIDS 2.0


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: Research Triangle Park

ORG_NAME: EPICYPHER, INC.

PHR: PROJECT NARRATIVE  Studying the activity of chromatin-associating proteins (CAPs) is central to understanding the regulatory mechanisms that control gene expression. However, existing assays to study CAPs either require expensive sequencing and complex data analysis or do not specifically capture chromatin-bound CAPs. Here, EpiCypher is developing a novel, sequencing-free assay that will make accessible the study of global in vivo activity of CAPs.

PI_NAMEs: SUN, ZU-WEN  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: assay development;Autoimmune;Benchmarking;Binding;Binding Proteins;Biological Assay;Biological Process;Biomedical Research;Cell Line;Cell Physiology;cell type;Cells;Cellular biology;ChIP-seq;Chromatin;Cleavage Under Targets and Release Using Nuclease;commercialization;Complex;complex data;cost;Data Analyses;Detection;Development;Disease;DNA;Dose;drug development;drug mechanism;EMSA;Enzyme-Linked Immunosorbent Assay;Equipment;Gene Expression;Gene Expression Regulation;Genes;Genomics;Health;high-throughput drug screening;Immune;improved;In Situ;in vivo;Inflammation;Inflammatory;innovation;Laboratories;Manuals;Maps;Marketing;Measurement;member;miniaturize;novel;novel therapeutics;Performance;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacotherapy;Phase;Post-Translational Protein Processing;programs;Proteins;Protocols documentation;Reader;Reproducibility;Research;research and development;Research Personnel;response;Response to stimulus physiology;Role;Services;Signal Transduction;Stains;Stimulus;Time;Titrations;Transcript;transcription factor;transcriptome sequencing;Validation;Work

PROJECT_TITLE: Rapid and robust assay for measurement of in vivo activity of chromatin-interacting proteins


NIH_SPENDING_CATS: Aging;Bioengineering;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Brains demand significant amounts of glucose as a means to maintain neural function, and while a decline in this usage is a hallmark of both aging and Alzheimer’s disease, it is not possible to discern whether this decrease directly impairs neuronal communication in vivo with current techniques. This proposal presents a novel system for monitoring and manipulating glucose metabolism at a single cell resolution such that impacts of different metabolic states can be directly related to changes in neuronal function. This fundamental work is expected to provide a molecular mechanism for age-related neuronal decline as derived from cellular metabolic context.

PI_NAMEs: WOLFE, AARON  (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: age related;Aging;Alzheimer's Disease;Animal Behavior;Apoptosis;assay development;Award;Behavior;Behavioral;Biology;Biosensor;blood glucose regulation;Brain;Caenorhabditis elegans;Calcium;Calcium Signaling;career;career development;Career Mobility;Categories;Cells;Characteristics;Chemotaxis;Chronic;Collaborations;Colon;Communication;Complement;cost;Data;Defect;Disease Progression;Equilibrium;experience;Exposure to;Faculty;Fructose;functional decline;Functional disorder;Genetic;Glucose;glucose metabolism;glucose uptake;Glycolysis;Goals;Homeostasis;Hypoxia;Image;Impairment;In Vitro;in vivo;Individual;inorganic phosphate;insight;Ion Channel;Learning;life span;Link;Measures;Mediating;Mentorship;Metabolic;Metabolism;Methods;Mitochondria;Modeling;Molecular;Monitor;NADP;network dysfunction;neural;Neuronal Dysfunction;neuronal metabolism;Neurons;Neurophysiology - biologic function;Neurosciences;novel;Occupations;Opsin;Orthologous Gene;Oxidation-Reduction;Pathway interactions;Pentosephosphate Pathway;Phase;prevent;Production;Proteins;Research;Resolution;response;Rest;sensor;skills;Sodium Chloride;Source;Specific qualifier value;Stimulus;Stress;System;Techniques;Time;Tissues;tool;Training;Universities;Visualization;Visualization software;Work

PROJECT_TITLE: Adaptive glycolysis as a regulator of neuronal function and decline

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]