NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infant Mortality;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: JACKSON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Our NICU and Division of Newborn is well positioned to be selected as a clinical center in NRN because of High-risk population of diverse racial and ethnic from state with well-described health disparities A strong infrastructure base, experienced research team, and a strong culture of research

PI_NAMEs: BHATT, ABHAY J (contact);FAMUYIDE, MOBOLAJI

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Address;Admission activity;Agreement;American College of Obstetricians and Gynecologists;arm;autism spectrum disorder;base;Behavior Disorders;bench to bedside;Cardiorenal syndrome;Caring;Centers of Research Excellence;Child;Child Welfare;Childhood;clinical center;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Data Monitoring Committees;Clinical Trials Network;Collaborations;community intervention;Compassion;Conduct Clinical Trials;Dedications;Development;disparity reduction;economic disparity;Eligibility Determination;eligible participant;Enrollment;Ethics;ethnic minority;Ethnic Origin;experience;Faculty;fetal;follow-up;Funding;Future;Goals;Health;health care disparity;health disparity;Health Personnel;Healthcare;high risk;high risk population;Hour;improved;Industry;Infant;Information Systems;Infrastructure;innovation;Institution;Intervention Studies;Intravenous;Life;Link;Low Birth Weight Infant;low socioeconomic status;maternal hypertension;Medical center;Medicine;Metabolic Diseases;mid-career faculty;Mission;Mississippi;Multi-Institutional Clinical Trial;Multicenter Neonatal Research Network;multidisciplinary;National Institute of Child Health and Human Development;Neonatal;neonatal health;Neonatal Intensive Care Units;neonatal pulmonary hypertension;Newborn Infant;next generation;Obesity;Observational Study;Outcome;Participant;Patient Care;Perinatal;Population;Positioning Attribute;Pre-Eclampsia;Pregnancy;Premature Birth;programs;public health insurance;racial diversity;racial minority;Recording of previous events;recruit;Reproducibility;Research;Research Infrastructure;Research Personnel;rural area;Services;Site;Study Subject;success;System;Training;Translational Research;Translations;Treprostinil;Underserved Population;United States National Institutes of Health;Universities;urban area;Vision;Work

PROJECT_TITLE: Childrens' of Mississippi Neonatal Research Group


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences

ORG_CITY: BOCA RATON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTHER BASIC SCIENCES

ORG_FIPS: US

ORG_NAME: FLORIDA ATLANTIC UNIVERSITY

ORG_STATE: FL

PHR: Narrative for “Neuroinflammation, neuronal IL-1R1, and behavior” This study investigates the role of nIL-1R1 in mediating neuroinflammation induced neuropathology and behavioral deficits. We will create an atlas of nIl-1R1, demonstrate the involvement of nIl-1R1 in neuroinflammation induced behavioral changes, and elucidate the mechanisms of nIl-1R1 mediated modulation of neuronal function and connectivity.

PI_NAMEs: QUAN, NING  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Acute Brain Injuries;Adhesions;Aging;Anatomy;Animal Model;Atlases;Behavior;Behavioral;behavioral study;Binding;Brain;Brain Mapping;cell type;Cells;Central Nervous System Diseases;Chronic;CNS autoimmune disease;comorbidity;cytokine;Data;design;Development;Disease;Epilepsy;Etiology;fighting;Genetic Polymorphism;Genetic Predisposition to Disease;Glutamates;Hippocampus;Human Genetics;IL1R1 gene;Impaired cognition;Inflammatory;Interleukin-1;Interleukin-1 Receptors;Knock-in;Knock-in Mouse;Label;Light;Link;LoxP-flanked allele;Maps;Mediating;Memory impairment;Mental disorders;Methods;Microscopy;Modeling;Molecular;Mood Disorders;mRNA Expression;Mus;Nervous System;Neurodegenerative Disorders;neuroinflammation;Neurologic;Neurons;neuropathology;neuroregulation;Neurotransmitters;novel;Pathogenesis;Pathology;Pathway interactions;Predisposition;prevent;protein expression;Protein Tyrosine Phosphatase;psychologic;Psychopathology;receptive field;receptor;Reporter;response;Role;Short-Term Memory;Signal Pathway;Signal Transduction;single cell sequencing;social;Stress;Synapses;synaptogenesis;System;Tracer;Withdrawal

PROJECT_TITLE: Neuroinflammation, Neuronal IL-1R1, and Behavior

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PI_NAMEs: SUSIARJO, MARTHA  (contact)

PROJECT_TERMS: Address;Applications Grants;Area;Award;Basic Science;Biological Models;Biostatistics Core;career development;Clinical Sciences;Collaborations;Communication;Communities;community engagement;community involvement;community partners;community partnership;Conflict of Interest;Consultations;Core Facility;Country;Data;Data Analyses;Development;Direct Costs;Disease;Environment;environmental agent;Environmental Health;Epidemiology;Evaluation;Extramural Activities;Faculty;faculty support;Feedback;Fostering;Funding;Future;Goals;Grant;Health protection;health science research;Health Sciences;Human;innovation;Interdisciplinary Study;interest;Lead;Medical center;meetings;member;National Institute of Environmental Health Sciences;new technology;novel;Output;Pilot Projects;Population;Process;Program Development;programs;Public Health;Publications;recruit;Research;Research Activity;Research Design;Research Personnel;Research Project Grants;Research Support;Review Committee;Role;senior faculty;success;Teacher Professional Development;Testing;Time;Translational Research;Universities;webinar;Work;Writing

PROJECT_TITLE: Pilot Project Program


ADMINISTERING_IC: GM

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: LEXINGTON

ORG_DEPT: ZOOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative  Mosquitoes transmit deadly diseases. The research proposed in this application will provide information of potential importance for development of insecticides for vector control. The proposed studies will reveal functions and mechanisms of action of epigenetic marks, which will help in understanding epigenetics of human diseases such as cancer.

PI_NAMEs: PALLI, SUBBA R (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Acetylation;Adult women;Aedes;Agonist;Animals;Antibodies;Binding;Bioinformatics;Biological Assay;Biological Metamorphosis;Biological Models;Cell Culture Techniques;Cells;chromatin immunoprecipitation;commercialization;Complex;CRISPR/Cas technology;Culicidae;Data;Deacetylation;demethylation;Development;Developmental Process;Disease;Disease Vectors;Ecdysone;ecdysone receptor;Ecdysteroids;Ecdysterone;Embryonic Development;Endocrinology;Ensure;Environment;enzyme activity;Enzymes;Epigenetic Process;epigenetic regulation;experimental study;Female;Food;Friends;gene product;Genes;genome annotation;genome editing;Goals;Growth;histone acetyltransferase;Histone Deacetylase;histone demethylase;histone modification;Histone-Lysine N-Methyltransferase;Histones;Homologous Gene;hormone analog;Hormone Receptor;hormone regulation;hormone response element;Hormones;Human;human disease;Insect Control;insect disease vector;Insect Hormones;Insecta;Insecticides;Juvenile Hormones;Knowledge;Laboratories;Life;Ligands;Literature;Livestock;Malignant Neoplasms;mass spectrometer;Mass Spectrum Analysis;Mediating;Medicine;Methods;Methoprene;Methylation;Modeling;Modification;Molecular;Pathway interactions;Pest Control;Physiological;Physiological Processes;Plants;Play;Postembryonic;Principal Investigator;Process;programs;promoter;Proteins;Publishing;receptor;receptor binding;Regulation;Reporter;Reproduction;Reproductive Process;Research;Research Support;response;Response Elements;RNA Interference;Role;Steroid Receptors;success;Testing;Tissues;transcription factor;transcriptome sequencing;transmission process;Tribolium;vector control;Vertebrates;Western Blotting;yeast two hybrid system

PROJECT_TITLE: Epigenetic regulation of hormone action in Tribolium and Aedes

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Eczema / Atopic Dermatitis;Food Allergies

ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

ORG_STATE: CO

PHR: PROJECT NARRATIVE In response to RFA-AI-19-015, the purpose of this application is to establish an Atopic Dermatitis Research Network - Clinical Research Center (ADRN-CRC) at National Jewish Health (NJH) to conduct ADRN network-wide clinical research projects under the leadership of the ADRN-Leadership Center (ADRN- LC). In parallel, single-center clinical and mechanistic research at NJH will evaluate mechanisms underlying children with atopic dermatitis (AD) and food allergy as well as AD associated with eczema herpeticum. Our central hypothesis is that different phenotypes and endotypes of AD are associated with distinct defects in their skin barrier and cutaneous immune responses.

PI_NAMEs: GOLEVA, ELENA ;LEUNG, DONALD YM (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Adult;Archives;Area;Atopic Dermatitis;biological adaptation to stress;Biological Markers;Cell Line;Child;Childhood;Clinical;clinical center;Clinical Research;Cutaneous;cytokine;Defect;Disease;Eczema Herpeticum;Environment;Enzymes;Epithelium;experience;Exposure to;Fibroblasts;filaggrin;follower of religion Jewish;Food Hypersensitivity;Functional disorder;Genetic Risk;genome sequencing;Genomics;Goals;Health;Herpesvirus 1;Human;Human Resources;Immune response;in vivo;Inflammation;Infrastructure;Institutional Review Boards;Intervention;keratin 5;keratinocyte;keratinocyte differentiation;Knowledge;Laboratories;laboratory facility;Leadership;Link;lipidomics;Lipids;Memory;Metabolism;Molecular Target;Mutation;novel;Oxidants;Oxidative Stress;Patients;Pharmaceutical Services;Phenotype;Population;Post-Translational Protein Processing;programs;Proliferating;Proteins;Proteomics;Recording of previous events;recruit;Recurrence;Research;research facility;Research Project Grants;response;risk variant;Role;Sampling;Shipping;Signal Transduction;Simplexvirus;Skin;skin barrier;skin biopsy;skin hypersensitivity;Sphingolipids;Training;Training and Infrastructure;transcriptome;Viral;Virus Diseases;Virus Replication;whole genome

PROJECT_TITLE: ATOPIC DERMATITIS RESEARCH NETWORK (ADRN) CLINICAL RESEARCH CENTER


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Burden of Illness;Cardiovascular;Clinical Research;Contraception/Reproduction;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Heart Disease - Coronary Heart Disease;Hypertension;Infant Mortality;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: CHARLESTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE The global COVID-19 pandemic caused by SARS-CoV-2 has highlighted the extent to which social determinants and inequities impact healthcare received and health outcomes. This project will evaluate maternal and infant effects following the COVID-19 pandemic and SARS-CoV-2 infection during pregnancy including pregnancy complications, adverse birth outcomes, maternal and infant mortality, and maternal one-year post pregnancy cardiovascular and mortality outcomes with a focus on social determinants of health and racial/ethnic differences. Better understanding of the impact of the COVID-19 pandemic and SARS-CoV-2 infection during pregnancy on maternal and infant morbidity and mortality is needed to guide clinical practice and public health prevention efforts for at-risk populations.

PI_NAMEs: HUNT, KELLY J;MALEK, ANGELA M (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: 2019-nCoV;Admission activity;adverse birth outcomes;African American;Birth;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Caring;Censuses;Clinic;clinical care;clinical practice;comorbidity;Coronary heart disease;coronavirus pandemic;COVID-19;COVID-19 diagnosis;COVID-19 incidence;COVID-19 pandemic;COVID-19 pandemic effects;COVID-19 prevalence;COVID-19 test;Data;Data Set;Death Rate;Diabetes Mellitus;Disparity;Economics;Embolism;Emergency department visit;ethnic difference;ethnic disparity;Ethnic Origin;Event;Extracorporeal Membrane Oxygenation;follow-up;Functional disorder;Health;health care availability;health care service;health difference;health disparity;health inequalities;Health Policy;Healthcare;Hispanic;Hospitalization;human old age (65+);Hypertension;improved;indexing;Infant;infant morbidity;infant morbidity/mortality;Infant Mortality;infant outcome;Infection;Intensive Care Units;Interruption;Job loss;Left;Link;Live Birth;Longitudinal cohort;maternal diabetes;maternal morbidity;Maternal Mortality;maternal obesity;maternal outcome;maternal risk;Measures;Mechanical ventilation;Medicaid;Medical;Minority Groups;Morbidity - disease rate;mortality;Mothers;Myocardial Infarction;novel;Obesity;Outcome;outcome disparities;pandemic coronavirus;pandemic disease;Population;population based;Population Study;Populations at Risk;post pregnancy;Pre-Eclampsia;pre-pandemic;Pregnancy;Pregnancy Complications;Pregnancy Outcome;pregnant;Pregnant Women;Premature Birth;prepregnancy;prepregnancy obesity;Prevention;Public Health;Race;racial difference;racial disparity;Records;Reporting;Risk;Risk Factors;SARS-CoV-2 infection;SARS-CoV-2 positive;severe maternal morbidity;Small for Gestational Age Infant;social;social determinants;social disparities;Social Distance;social health determinants;social vulnerability;Social Work;South Carolina;Stroke;Testing;Time Series Analysis;Transportation;United States;Vascular Diseases;ventilation;Ventricular;Woman;Women's cohort;Women's Health

PROJECT_TITLE: Impact of the COVID-19 pandemic, SARS-CoV-2 infection and social determinants of health on pregnancy complications, birth outcomes and post-pregnancy maternal cardiovascular and mortality outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(90)]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infant Mortality;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Emory University, in partnership with Children's Healthcare of Atlanta, is nationally recognized as a leader in pediatric healthcare and has received continuous funding and made significant contributions to the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network (NRN) since 1991. Our site brings a large available patient population with high follow-up rates, state-of-the-art clinical and research facilities and clinical research infrastructure, strong investigators with extensive clinical research expertise, and excellent research support staff. Emory will continue to contribute to the scientific missions of the NRN through development of innovative research protocols and conduct of clinical trials and observational studies to address important unanswered clinical questions in neonatal medicine.

PI_NAMEs: PATEL, RAVI MANGAL (contact)

PROJECT_TERMS: Address;Admission activity;adverse outcome;Area;Asian;autism spectrum disorder;biomarker development;Biomedical Engineering;biomedical informatics;biomedical referral center;Black race;Blood Platelets;Boston;Bronchopulmonary Dysplasia;Caffeine;Caring;Centers for Disease Control and Prevention (U.S.);Cerebral Palsy;Cessation of life;Characteristics;Child;Child Health;Child health care;Childhood;Cities;Clinical;clinical epidemiology;clinical infrastructure;Clinical Investigator;Clinical Research;Clinical Trials;Collaborations;Communicable Diseases;Conduct Clinical Trials;cost;Development;Discipline of obstetrics;Enrollment;Ensure;Epidemiology;Ethics;experience;extreme prematurity;Faculty;Family;follow-up;Funding;Gynecology;Health system;Hemorrhage;high risk;Hispanic;Hospitals;Hour;implementation science;improved;Indiana;Individual;Infant;Infrastructure;innovation;Institution;International;Intervention;Lactation;Link;Live Birth;maternal risk;Measures;Medicine;Methodology;metropolitan;Mission;Multi-Institutional Clinical Trial;Multicenter Neonatal Research Network;National Institute of Child Health and Human Development;Necrotizing Enterocolitis;Neonatal;Neonatology;Neurophysiology - biologic function;Neurosciences;Newborn Infant;nutrition;Observational Study;Outcome;Paper;participant enrollment;patient population;Patients;pediatric department;Perinatal;Perinatal Epidemiology;Persons;Pharmacology;Platelet Transfusion;Population;Pregnancy;Productivity;programs;protocol development;Protocols documentation;Public Health Schools;Publications;randomized trial;Reproducibility;Research;research facility;Research Infrastructure;Research Personnel;Research Support;Research Training;Role;Services;Site;sociodemographics;success;Talents;Technology;Testing;transfusion medicine;Translating;Underserved Population;United States National Institutes of Health;Universities;University Hospitals;unnecessary treatment;vaccine development;Work

PROJECT_TITLE: NICHD Neonatal Research Network


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: BETHLEHEM

ORG_DEPT: BIOLOGY

ORG_NAME: LEHIGH UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE  Adaptive genome evolution has produced the remarkable diversity of life on Earth, yet it is also the process by which pathogens and cancers resist drug treatments and evade the immune system. High- throughput experimental evolution is a powerful and versatile technique that provides a way to test evolutionary theory in the laboratory with exquisite control over experimental parameters. By identifying the genes and pathways that respond to selective pressures, the proposed experiments will not only advance our understanding of the process of adaptive evolution but will lead to new mechanistic insights into how genetic variation produces the phenotypes on which selection acts.

PI_NAMEs: LANG, GREGORY I (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Address;Antibiotic Resistance;Biological Assay;Biology;Complex;Cytoplasm;Environment;Evolution;experimental study;functional genomics;Future;gene environment interaction;Gene Pool;Generations;Genes;Genetic;Genetic Variation;Genome;Genotype;Health;Human;human pathogen;Immune Evasion;Immune system;insight;Knowledge;Laboratories;Life;Malignant Neoplasms;Methods;Mutation;Nuclear;pathogen;pathogenic virus;Pathway interactions;Pharmacotherapy;Phenotype;Planet Earth;Population;pressure;Process;purge;System;Techniques;Testing;theories;Time;tool;trait;Variant;Work;Yeasts

PROJECT_TITLE: Genetic interactions and the evolution of complex traits in yeast

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: DURHAM

ORG_DEPT: NEUROSURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Public Health Relevance Glioblastoma (GBM) is the most common and aggressive type of brain cancer in adults, and effective treatment for GBM remains an unmet need. Therefore, it is critical to evaluate novel therapeutic approaches that will be beneficial for individuals afflicted with this debilitating disease. To develop protective antitumor immunity and improve GBM patient survival, we propose to simultaneously destroy tumor cells and activate microglia/macrophages, specialized immune cells in the tumor microenvironment. This study should result in the development of a novel therapeutic combination that will improve GBM patient survival.

PI_NAMEs: CHANDRAMOHAN, VIDYALAKSHMI  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Ablation;Abscopal effect;Adult;Affinity;Animal Model;Animals;anti-tumor immune response;Antigen Presentation;Antigen-Presenting Cells;Antigens;Antitumor Response;Automobile Driving;Binding;Brain;Brain Neoplasms;CD8-Positive T-Lymphocytes;CD8B1 gene;cell growth;cell killing;Cells;Clinic;Clinical;clinical translation;Combined Modality Therapy;Contralateral;cytotoxic;cytotoxic CD8 T cells;Cytotoxic Chemotherapy;Death Rate;Dedications;defined contribution;Development;Disease;Education;effective therapy;Effectiveness;effector T cell;Epidermal Growth Factor Receptor;Generations;glial activation;Glioblastoma;Glioma;Goals;Immune;Immunocompetent;Immunoglobulin Fragments;Immunosuppression;Immunotoxin Therapy;Immunotoxins;improved;In Vitro;in vivo;Individual;Inflammatory;Infusion procedures;innovation;insight;Ipsilateral;ITGAX gene;Ligation;Macrophage;Malignant neoplasm of brain;Mediating;Mediator;Microglia;Modeling;Molecular;Multiple Sclerosis;Mus;mutant;neoplastic cell;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Oncogenes;Outcome;patient response;patient subsets;Patients;Phagocytosis;Phase I Clinical Trials;Phenotype;pre-clinical;preclinical study;Primary Brain Neoplasms;Productivity;public health relevance;radiological imaging;Radiology Specialty;Recombinant Antibody;Recurrence;Research;response;Role;subcutaneous;survival outcome;T cell infiltration;T cell response;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;TNFRSF5 gene;transcriptomic profiling;transcriptomics;Translating;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;Tumor Promotion;Tumor-associated macrophages;tumor-immune system interactions;tumorigenic;Variant

PROJECT_TITLE: Synergistic microglial activation and tumor cell killing for improved GBM response

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: NEW YORK

ORG_NAME: CHILD MIND INSTITUTE, INC.

PHR: NARRATIVE This application proposes an approach consistent with precision medicine for the study of autism. It will do so through the identification of homogenous brain connectome-based subtypes (i.e., neurosubtypes) that are reproducible and clinically relevant. This will be accomplished through the creation of a large-scale, aggregate data resource to support mega-analysis of the connectome in autism during childhood; the resource will be shared to maximize impact.

PI_NAMEs: DI MARTINO, ADRIANA  (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: 18 year old;Address;Age;Algorithms;Attention;autism spectrum disorder;autism symptoms;Bayesian Method;Bayesian Modeling;Biological;biological heterogeneity;biological research;boys;Brain;brain abnormalities;brain behavior;Brain imaging;Caring;Characteristics;Child;Childhood;Clinical;Clinical Data;clinical heterogeneity;clinical phenotype;Clinical Protocols;clinically relevant;Collection;combat;Communities;connectome;Data;Data Aggregation;Data Collection;data exchange;data harmonization;data resource;Databases;Diagnosis;Diagnostic Specificity;Dimensions;Functional Magnetic Resonance Imaging;girls;Goals;Grain;Heterogeneity;Hybrids;Image;improved;indexing;Individual;individuals with autism spectrum disorder;Knowledge;large datasets;Magnetic Resonance Imaging;Measurement;Measures;Methodology;Methods;Modeling;mosaic;Nature;neural;neuroimaging;neurophysiology;Neurosciences;novel;Pattern;Phenotype;phenotypic data;precision medicine;quality assurance;repetitive behavior;Reproducibility;Research;Resources;response;Rest;Sample Size;Sampling;sex;Site;social communication;social structure;Source;Structure;Subgroup;Symptoms;Syndrome;System;Systems Analysis;Testing;theories;Time;Variant;Work

PROJECT_TITLE: A mega-analysis framework for delineating autism neurosubtypes


ADMINISTERING_IC: CA

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative The molecular mechanisms involved in maintaining mitochondrial redox homeostasis and the role of mitochondrial antioxidants in tumor progression are poorly understood. To address this, we will test the hypothesis that mitochondrial GSH maintenance is essential for breast cancer progression and metastasis. Our work will provide unprecedented insight into the role of mitochondrial GSH homeostasis in cancer progression and may identify therapeutic strategies to prevent breast cancer metastasis.

PI_NAMEs: BIRSOY, KIVANC  (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: Address;Antioxidants;Biochemical;Biological Assay;Brain;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Model;Breast Cancer Patient;Breast Cancer Prevention;breast cancer progression;breast cancer survival;cancer cell;cancer type;Cell Physiology;Cytosol;Dependence;Engineering;Environment;Enzymes;Experimental Genetics;experimental study;Genetic;genetic approach;Genetically Engineered Mouse;Glutathione;Homeostasis;Human;in vivo;insight;Invaded;Link;Liposomes;Liver;Lung;lung colonization;Maintenance;Malignant Breast Neoplasm;Mammary Neoplasms;Mediating;Metabolic;Metabolism;Metastatic Neoplasm to the Lung;Methods;Mitochondria;mitochondrial membrane;Molecular;Mus;Mutation Analysis;Neoplasm Metastasis;Organ;Organelles;Oxidation-Reduction;Pathway interactions;patient derived xenograft model;Pharmaceutical Preparations;pressure;Production;Prognosis;Proteins;Proteomics;Publishing;Reactive Oxygen Species;Regulation;Resistance;response;Role;Signal Transduction;Site;small molecule;Source;Sulfhydryl Compounds;Testing;Therapeutic;Time;Toxic effect;tumor;tumor growth;tumor progression;tumorigenesis;uptake;Work

PROJECT_TITLE: The role of mitochondrial glutathione homeostasis in tumor formation

STUDY_SECTION: CCB

STUDY_SECTION_NAME: Cancer Cell Biology Study Section[CCB]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Chronic Pain;Drug Abuse (NIDA only);Lung;Neurosciences;Opioids;Pain Research;Substance Misuse

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE Opioids are highly effective for pain management, yet the respiratory depression that they induce has massive health consequences. Despite its significance, the mechanisms underlying opioid-induced respiratory depression (OIRD) are not well understood. This project combines computational and experimental approaches to unravel how opioid-sensitive interactions between brainstem respiratory and pain circuits contribute to OIRD and explores strategies to dissociate analgesia and respiratory depression.

PI_NAMEs: PHILLIPS, RYAN SEAN (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Absence of pain sensation;addiction;Address;Affect;Analgesics;antagonist;Apnea;Attenuated;Automobile Driving;Award;behavioral study;Brain Stem;Breathing;career;Career Choice;Cause of Death;Cell Nucleus;cell type;Cells;Cessation of life;Clinical;Complex;Computer Models;cost;cost effective;Coupled;Dangerousness;Data;Data Set;data-driven model;Development;Disparate;Dissociation;Frequencies;Generations;Genes;Genetic;Health;improved;in vivo;in vivo evaluation;Injections;insight;Interruption;Investigation;Life;Link;Mediating;Mentored Research Scientist Development Award;Microinjections;Modeling;Molecular Target;neural circuit;Neurobiology;Neurons;novel;Opiate Addiction;Opioid;opioid epidemic;opioid injection;opioid mortality;Opioid Receptor;optogenetics;Overdose;Pain;Pain Clinics;Pain management;pain perception;pain relief;parabrachial nucleus;Pattern;pharmacologic;Play;Population;preBotzinger complex;prevent;Productivity;Property;Public Health;receptor;recombinase;Recording of previous events;Regulation;Research;Respiration;respiratory;Respiratory Center;Respiratory physiology;response;Role;Shapes;side effect;Site;Testing;Therapeutic;therapeutic target;Training;Update;Ventilatory Depression;Viral

PROJECT_TITLE: Dissociating respiratory depression and analgesia via a data-driven model of interacting respiratory and pain networks

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-J(02)M]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Regenerative Medicine

ORG_CITY: MILWAUKEE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE The central nervous system, including the visual system, of humans and other mammals has very limited capacity to regenerate following injury or degeneration. We are studying an animal, zebrafish, that successfully regenerates and recovers lost vision following optic nerve injury. The focus of this project is to study signaling and metabolic pathways that regulate successful optic nerve regeneration in zebrafish and then test them in a preclinical mouse model of optic nerve injury with the hope that they can be translated to enhance regeneration in human patients in the future.

PI_NAMEs: VELDMAN, MATTHEW B (contact)

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: Acceleration;Acute;Affect;American;Animals;antagonist;Axon;axon injury;axon regeneration;Biological;Blindness;Brain;cell injury;Cell Survival;Cells;Central Nervous System;Chemicals;Cholesterol;cholesterol trafficking;Coenzyme Q10;cost;critical period;Data;Data Set;differential expression;disease model;Drug Combinations;Exhibits;experimental study;extracellular;Failure;Financial Hardship;Future;gain of function;Gene Expression;Gene Transfer;Genes;Genetic;Genetic Transcription;Glaucoma;glycosylation;Goals;Growth;Growth Cones;Human;improved;in vivo;in vivo Model;Injury;innovation;knock-down;Knowledge;laser capture microdissection;Lipids;loss of function;Low Density Lipoprotein Receptor;Mammals;Measures;Mediating;Mediator;Medical;Metabolic Pathway;mevalonate;model organism;Modeling;mouse model;Mus;Natural regeneration;nerve injury;neural;neuroprotection;novel;novel therapeutics;Optic Nerve;optic nerve disorder;Optic Nerve Injuries;optic nerve regeneration;Organism;overexpression;Pathology;Pathway interactions;Patients;pharmacologic;Photic Stimulation;pre-clinical;Pre-Clinical Model;Process;prophylactic;Protein Import;Protein Isoprenylation;Proteins;receptor expression;Recovery;Recycling;regeneration following injury;Regenerative Medicine;Regulation;Reporter;Reporter Genes;response;retinal ganglion cell regeneration;Retinal Ganglion Cells;Role;sight restoration;Signal Pathway;Source;success;Synapses;System;teleost fish;Testing;Time;Tissue-Specific Gene Expression;tool;transcriptome;transcriptome sequencing;transcriptomics;Transgenic Organisms;Translating;Ubiquinone;United States;Up-Regulation;Vision;Visual System;Zebrafish

PROJECT_TITLE: Regulation of successful optic nerve regeneration by the mevalonate/cholesterol pathway

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Despite major advances in pharmaceutical and behavior interventions, mental illnesses still account for about one-third of the world’s disability caused by all adult health problems, resulting in enormous personal suffering and socioeconomic costs. This project will address this urgent unmet need by producing tool compounds to enable experiments to validate new therapeutic targets for the treatment of mental disorders.

PI_NAMEs: JACKSON, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: MANDELBLAT-CERF, YAEL

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Agonist;antagonist;Anxiety;Behavior Therapy;beta-Galactosidase;Binding;Biological;Biological Assay;Brain;Cells;Cellular Assay;Chemical Structure;Chemicals;cheminformatics;Collection;Communities;counterscreen;Data;disability;Disease;Drug Targeting;economic cost;emotional abuse;Endoplasmic Reticulum;Engineering;Enzymes;established cell line;experimental study;Family;G-Protein-Coupled Receptors;Gene Expression;Genetic;Goals;Health;Healthcare Systems;high throughput screening;high throughput technology;Human;human model;improved;In Vitro;Induced pluripotent stem cell derived human neuron;innovation;Intention;Intervention;Ion Channel;Knowledge;Label;Libraries;Ligands;liquid chromatography mass spectrometry;Maps;Medical;Medicine;Mental Depression;Mental disorders;Mental Health;Microelectrodes;Modification;Molecular Conformation;Monitor;neural network;Neurons;Neurosciences;new therapeutic target;novel;Nuclear Receptors;Orphan;Patients;Pattern;Performance;Pharmaceutical Chemistry;pharmacologic;Pharmacologic Substance;Pharmacology;Phenotype;prevent;Property;Protocols documentation;psychologic;Publishing;receptor;receptor function;Reporter;Resolution;Role;scaffold;Schizophrenia;screening;side effect;Signal Transduction;social interventions;Societies;socioeconomics;Structure;Structure-Activity Relationship;Substance abuse problem;System;Technology;Testing;Therapeutic;tool;trafficking;Validation;Work

PROJECT_TITLE: A Pharmacochaperone-based strategy for identifying chemical probes of brain-derived orphan GPCRs

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases;Zika Virus

ORG_CITY: CHAPEL HILL

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Program Narrative Many people living in tropical regions of the world are infected by multiple viruses transmitted by mosquitos and other blood feeding arthropods. With currently available laboratory methods, it is difficult to detect specific antibodies induced by arbovirus infections or candidate vaccines. We will develop a new assay that will be able to accurately detect specific antibodies to different arboviruses and arbovirus vaccines in a single drop of blood.

PI_NAMEs: DESILVA, ARAVINDA M. (contact);LAKSHMANANE, PREMKUMAR

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: accurate diagnosis;Acute;Aedes;Africa;Alpha Virus;Americas;Antibodies;Antibody Response;Antigens;Arbovirus Infections;Arboviruses;Area;Arthropods;Asia;Biological Assay;Blood;Central America;Chikungunya virus;Child;Clinical Research;Clinical Trials;Cohort Studies;Consumption;cross reactivity;Culicidae;Dengue;Dengue Infection;Dengue Vaccine;Dengue Virus;Detection;detection assay;Development;Diagnosis;Disease;Drops;Ecology;Environment;Epidemic;Epitopes;experience;Exposure to;Far East;feeding;Fever;Flavivirus;Flavivirus Infections;Fluorescence;Human;Immune;Immunity;Individual;Infection;Laboratories;Latin America;Length;Location;Mayaro virus;Measures;Methods;Microspheres;minimally invasive;Monitor;multiplex assay;neutralizing antibody;Newly Diagnosed;North Carolina;novel;Performance;Persons;Phase III Clinical Trials;Population;predicting response;programs;Proteins;Recombinants;Recording of previous events;Risk;Safety;sample collection;Sampling;Serology;Serology test;Serotyping;Serum;severe dengue;Specificity;Specimen;Technology;Testing;Ticks;Time;transmission process;Undifferentiated;United States National Institutes of Health;urban setting;Urbanization;vaccine candidate;vaccine development;vaccine efficacy;vaccine safety;vaccine trial;vaccine-induced antibodies;Vaccines;viral detection;Viral Proteins;viral transmission;Virion;Virus;Yellow fever virus;Zika Virus;Zika virus vaccine

PROJECT_TITLE: Multiplex serological assays to support arbovirus diagnosis, surveillance and vaccines


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: RENO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: PROJECT NARRATIVE Capillaries are the smallest vessels in circulatory system, yet make up majority of the vascular network and is the site of O2 and nutrients delivery and waste removal. The proposed work will test the hypothesis that amyloid-β (Aβ)—the major constituent of amyloid plaques in cerebral amyloid angiopathy and the brain of Alzheimer's patients— disrupts pericyte's control of local and regional capillary blood flow. As we gain a better understanding on of how blood flow is regulated within the microvasculature, pericytes represent a novel therapeutic target for cardiovascular and neurodegenerative diseases.

PI_NAMEs: GONZALES, ALBERT LOUIS (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: abeta accumulation;abeta oligomer;Adult;Affect;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid beta-Protein;arteriole;Blood;Blood capillaries;Blood flow;Blood Vessels;Brain;Cardiovascular Diseases;Cardiovascular Pathology;Cardiovascular system;Cell Membrane Permeability;Cells;Cerebral Amyloid Angiopathy;cerebral capillary;Cholesterol;constriction;Data;Daughter;Dementia;Deterioration;Disease;Electrophysiology (science);Endothelium;Environment;Erythrocytes;Event;Excision;Failure;Frequencies;Functional disorder;Genetically Engineered Mouse;Health;hemodynamics;Image;Impaired cognition;in vivo;in vivo evaluation;insight;Laser Scanning Microscopy;Lead;Lipid Bilayers;Lipids;Mediating;Membrane;Membrane Lipids;Molecular;Morphology;mouse model;Mus;Muscle Cells;Nerve Degeneration;neural;Neurodegenerative Disorders;neuron loss;Neurons;neuropathology;neurovascular unit;new therapeutic target;novel;Nutrient;Omega-3 Fatty Acids;Optics;Pathogenesis;Pathology;Perfusion;Pericytes;Permeability;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylinositols;Preparation;pressure;prevent;Prevention;Property;Regional Blood Flow;Resources;Retina;Role;Senile Plaques;sensor;Sensory;Signal Transduction;Site;Smooth Muscle Myocytes;STIM1 gene;Stimulus;Supporting Cell;Techniques;Testing;therapeutic target;Tissues;Transgenic Mice;two-photon;Vascular Diseases;Vascular Smooth Muscle;voltage;wasting;Work

PROJECT_TITLE: Amyloid-β Disruption of Pericyte Control of Capillary Hemodynamics


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: SANTA CRUZ

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: Narrative This grant will support 5 postdocs (4 NIH-sponsored and 1 UCSC-sponsored) at UC Santa Cruz’ Institute for the Biology of Stem Cells to undergo rigorous research training and targeted career skill development in order to succeed in careers spanning from academic research to biotechnology and advocacy. An important aspect of our program is structured mentoring which has been shown to improve career outcomes and increase the motivation of postdoctoral fellows to enter the academic job market, especially for women and minority postdoctoral fellows. The unifying research focus is on stem cell-based models of pre-and postnatal development.

PI_NAMEs: CHEN, BIN ;HINCK, LINDSAY E (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: career;post-doctoral training;stem cell biology;Training Programs

PROJECT_TITLE: A postdoctoral training program for impactful careers in stem cell biology


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infant Mortality;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rural Health

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Some of the most important clinical advances in the field of neonatology have been derived from the research studies of the Neonatal Research Network and other similar collaborative clinical research. The impressive gains in survival and handicap-free survival for very premature infants over recent decades are directly the result of clinical research and its translation into clinical practice. The Neonatal Research Network will continue to advance the understanding of the complex needs of preterm infants and their families and to design interventions to optimize their health.

PI_NAMEs: COLAIZY, TARAH TRINITY (contact)

PROJECT_TERMS: Academic Medical Centers;Address;Agriculture;Area;career;Caring;Child;Childhood;Chronic Disease;Clinical;clinical practice;Clinical Research;Clinical Trials;Collaborations;Communities;Complex;Country;critically ill newborn;Development;Disease;Echocardiography;Enrollment;Ensure;extreme prematurity;Extremely Low Birth Weight Infant;Face;Family;follow up assessment;follow-up;Future;Health;Health Promotion;Healthcare;hemodynamics;Human;improved;Incidence;Infant;International;Intervention;Intervention Studies;Iowa;Knowledge;Longterm Follow-up;Measurement;Medicine;Methods;Mission;Modality;mortality;Multi-Institutional Clinical Trial;Multicenter Neonatal Research Network;Multicenter Studies;National Institute of Child Health and Human Development;Native American population;Neonatal;neonate;Neonatology;Neurodevelopmental Impairment;Newborn Infant;next generation;novel;Observational Study;Outcome;Outcome Assessment;Participant;Patients;periviable;Physiological;Population;population based;Pregnancy;premature;Premature Infant;Productivity;programs;Quality of life;Recording of previous events;Research;Research Design;Research Infrastructure;Research Personnel;research study;Resources;Rural;Rural Population;Science;Sioux Falls;Site;Subgroup;Survival Rate;Survivors;Testing;therapy design;Translations;United States;Universities;Voice;Vulnerable Populations;Work

PROJECT_TITLE: NICHD Cooperative Multicenter Neonatal Research Network


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BALTIMORE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE Early glaucoma detection with high sensitivity and specificity is greatly needed to prevent blindness and develop new therapies. This proposal aims to develop and validate novel imaging methods and quantitative markers, uniquely enabled by visible light optical coherence tomography, to detect glaucoma at its early stages. The success of this proposal would significantly improve the detection of early glaucoma damage, and benefit glaucoma management, treatment, and prevention.

PI_NAMEs: YI, JI  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: 3-Dimensional;Action Potentials;Address;Affect;Animals;Axon;axon injury;Axonal Transport;Benchmarking;Blindness;Blood;Blood flow;Blood Vessels;Cell Respiration;Cells;Cessation of life;Chronic;Clinical;clinical care;Clinical Research;Complex;Cross-Sectional Studies;Cytoskeleton;Data;design;Detection;Development;Devices;Disease;Early Diagnosis;Event;Eye;F-Actin;field study;Functional disorder;functional loss;ganglion cell;Ganglion Cell Layer;Generations;Glaucoma;Goals;high risk;Human;Image;imaging biomarker;imaging modality;improved;Individual;Inner Plexiform Layer;Light;Lighting;macula;Measurement;Measures;Methods;Microtubules;Modeling;Nerve;Neurofibrils;Neurons;neuroprotection;Noise;novel;novel therapeutics;Optic Disk;Optical Coherence Tomography;optical disc;Optics;Oxygen;Oxygen Consumption;Oxygen saturation measurement;Papillary;Pathologic;Performance;preservation;prevent;Prevention;programs;Prospective Studies;Public Health;Quality of life;rate of change;Reporting;Resolution;Retina;retina circulation;Retinal Ganglion Cells;retinal nerve fiber layer;Role;Scanning;Sensitivity and Specificity;Severities;Signal Transduction;Spectrum Analysis;Speed;Structure;submicron;success;Suspect Glaucomas;Synapses;System;Testing;therapy development;Thick;Thinness;Time;Tissues;transmission process;United States;Validation;Visible Radiation;Vision;Visual;Visual Fields

PROJECT_TITLE: Advancing visible light optical coherence tomography in glaucoma detection


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE Our study seeks to provide fundamental insights into the role of different subpopulations of dopamine neurons for reward learning and motivated behavior. To do this, we will conduct pharmacological manipulations, fiber photometry recordings, optogenetics and electrophysiological measurements in behaving mice. Because many neuropsychiatric diseases, including substance use disorder, involve maladaptive changes in reward and motivation brain circuits, the proposed study may lead to the identification of circuit-level targets that can guide the development of novel treatments in humans.

PI_NAMEs: LAMMEL, STEPHAN  (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Anatomy;Attention;Aversive Stimulus;Award;Behavior;Behavior Disorders;Behavioral;Brain;cell type;Cells;Cues;Development;Disease;Dopamine;dopamine system;dopaminergic neuron;Dose;Electrophysiology (science);experimental study;Fiber;Genetic Identity;Goals;Head;Health;Heterogeneity;Human;Image;improved;in vivo;incentive salience;Individual;insight;Intravenous infusion procedures;Investigation;Lateral;learned behavior;Learning;Location;Measurement;Measures;Medial;Mediating;Methodology;Microdialysis;motivated behavior;Motivation;Mus;Neuroanatomy;Neurons;neuropsychiatric disorder;Nicotine;Nicotinic Receptors;novel;Nucleus Accumbens;optogenetics;Outcome Study;Periodicity;pharmacologic;Photometry;Positioning Attribute;Prefrontal Cortex;Presynaptic Terminals;Prosencephalon;receptor function;response;Rewards;Role;Scanning;Source;Stimulus;Structure;Substance Use Disorder;Testing;Ventral Tegmental Area;Virus

PROJECT_TITLE: Circuit-specific mechanisms of reward and aversion in ventral tegmental area dopamine neurons

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Childhood Injury;Depression;Mental Health;Mental Illness;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Serious Mental Illness;Suicide;Suicide Prevention;Violence Research;Youth Violence

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Depression, non-suicidal self-injury (NSSI) and suicidal thoughts and behaviors (STB) commonly emerge in youth and each represent important risk factors for death by suicide. The current proposal seeks to delineate the neurodevelopmental trajectories of strength and flexibility in fronto-limbic, cortico-striatal and default mode networks associated with the risk, onset and early course of depression, NSSI and STB in children and adolescents in the ABCD study using novel analytic strategies. New insights from this study will provide the foundation for designing personalized interventions to facilitate early detection of depression and suicide risk, and to guide interventions capable of restoring healthy brain development and averting serious negative outcomes including suicide.

PI_NAMEs: CULLEN, KATHRYN REGAN (contact);FIECAS, MARK JOSEPH BARILAR

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: Adolescence;Adolescent;Adolescent and Young Adult;adolescent-onset depression;Adult;Age;Biology;Brain;brain shape;Cause of Death;Child;child depression;Childhood;Clinical;Cognitive;cognitive development;Corpus striatum structure;Data;Data Collection;Data Set;design;Development;Early Diagnosis;Early Intervention;Entropy;Environment;Environmental Risk Factor;Family;Feeling;Feeling suicidal;flexibility;follow-up;Foundations;Frequencies;Functional Magnetic Resonance Imaging;functional MRI scan;Future;genetic risk factor;improved;Impulsivity;Individual Differences;Information Theory;insight;Intervention;Knowledge;Laboratories;Link;longitudinal design;Measures;Mediating;Mental Depression;Methods;Modeling;neural;neural network;neuroimaging;neuromechanism;Neurosciences;non-suicidal self injury;novel;novel strategies;Outcome;personalized intervention;Persons;Population Study;prevent;Puberty;Recording of previous events;Reporting;Reproducibility;Research;Rest;Rewards;Risk;Risk Factors;Sampling;Self-Injurious Behavior;sex;Shapes;Signal Transduction;stressor;Structure;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;Symptoms;System;Thinking;Validation;Youth

PROJECT_TITLE: Developmental Trajectories of Brain Network Strength and Flexibility: Relationship to Risk, Onset and Course of Depression and Self-Harm in Youth

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Infant Mortality;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE The Eunice Kennedy Shriver NICHD cooperative multicenter Neonatal Research Network (NRN) is committed to providing a strong scientific evidence base for the care of sick and preterm newborns to promote healthy outcomes. The University of Pennsylvania Perelman School of Medicine (Penn) and Children’s Hospital of Philadelphia (CHOP) Clinical Center has been making significant contributions to all aspects of NRN research since 2011 and is fully prepared to continue our robust NRN participation in the next award cycle.

PI_NAMEs: DEMAURO, SARA BONAMO (contact);EICHENWALD, ERIC C

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Admission activity;Age;Award;Caring;Clinic;Clinical;clinical care;clinical center;Clinical Research;clinical trial enrollment;clinical trial protocol;Clinical Trials;cohort;Collaborations;Conduct Clinical Trials;Country;Education;Enrollment;Ensure;Epidemiologic Methods;evidence base;extreme prematurity;Faculty;fetal diagnosis;follow-up;Follow-Up Studies;Funding;Future;Goals;health disparity;high risk infant;Hybrids;improved outcome;Infant;Informed Consent;innovation;Inpatients;Intervention;Lactation;Leadership;Manuscripts;medical schools;meetings;member;microbiome;Milrinone;Mission;Multicenter Neonatal Research Network;National Institute of Child Health and Human Development;Neonatal;Neonatal Intensive Care Units;Neonatology;novel;Observational Study;Outcome;Outcome Study;Outpatients;participant enrollment;patient population;pediatric department;Pediatric Hospitals;Pennsylvania;Perinatal;Perinatology;Philadelphia;premature;preterm newborn;Principal Investigator;Productivity;Protocols documentation;Publications;Publishing;Randomized Controlled Clinical Trials;randomized trial;Records;recruit;Research;Research Methodology;Research Personnel;Resources;Sample Size;Schedule;School-Age Population;Scientific Advances and Accomplishments;Secure;Services;Site;Solid;Structure;success;symposium;Techniques;Transfusion;U-Series Cooperative Agreements;Universities;Visit;Writing

PROJECT_TITLE: Clinical Center for NICHD/Neonatal Research Network


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infant Mortality;Infectious Diseases;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: PROJECT NARRATIVE The Eunice Kennedy Shriver NICHD Neonatal Research Network (NRN) has been established to conduct multicenter, interventional, and observational clinical studies in neonates, including those who are preterm and of low birth weight. The goal of these studies is to reduce infant morbidity and mortality and promote healthy outcomes in high risk infants and children. The Division of Neonatology at The Abigail Wexner Research Institute at Nationwide Children’s Hospital (NCH) in collaboration with The Ohio State University (OSU) and its affiliated noenatal intensive care units has demonstrated a strong commitment to the NRN and remain committed to serve as one the network centers and enhance its productivity.

PI_NAMEs: SANCHEZ, PABLO J (contact)

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;antimicrobial;Behavioral;Board Certification;Bronchopulmonary Dysplasia;Cardiology;Child;Childhood;Clinical;clinical care;clinical infrastructure;clinical practice;Clinical Protocols;Clinical Research;Clinical Trials;Cognitive;Collaborations;Communicable Diseases;Consent;cultural equity;data acquisition;Dedications;Discipline of obstetrics;Disparity;Doctor of Philosophy;Eligibility Determination;Enrollment;Ensure;Evaluation;experience;extreme prematurity;Family;feeding;fetal;follow-up;Funding;Goals;health equity;Healthcare;high risk infant;Hospitals;improved;Individual;Infant;Infant Care;infant morbidity;infant morbidity/mortality;innovation;Intensive Care Units;International;Intervention;Joints;Lactation;Leadership;Longitudinal Studies;Low Birth Weight Infant;Maternal-Fetal Medicine Units Network;Medical;Medicine;Methodist Church;Mission;Multi-Institutional Clinical Trial;Multi-site clinical study;Multicenter Neonatal Research Network;National Institute of Child Health and Human Development;Neonatal;neonatal care;Neonatal Intensive Care Units;neonatal patient;neonate;Neonatology;Neurology;Newborn Infant;Observational Study;Ohio;opioid exposure;Outcome;patient population;Patient-Focused Outcomes;Patients;pediatric department;Pediatric Hospitals;Performance;Perinatal;perinatal medicine;Positioning Attribute;Premature Birth;Premature Infant;Principal Investigator;Productivity;programs;Protocols documentation;randomized trial;randomized, clinical trials;Recording of previous events;recruit;Referral and Consultation;Reproducibility;Research;Research Design;Research Infrastructure;Research Institute;research study;Research Support;Role;Safety;Source;Study Subject;systems research;Treatment Efficacy;U-Series Cooperative Agreements;United States National Institutes of Health;Universities;Vision;Work

PROJECT_TITLE: NICHD Neonatal Research Network (NRN)


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Patient Safety;Rural Health;Social Determinants of Health

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative The University of Virginia (UVA) and West Virginia University (WVU) are partnering to form a Linked Clinical Research Center to conduct heart and vascular clinical research trials with the goal of serving the vulnerable Appalachian community. This partnership has been designed to increase the capability of WVU to conduct clinical research trials using UVA’s excellent experience in heart and vascular research. Partnering these two universities will provide excellent teaching and support for trainees at both sites who are interested in working in the field of clinical research. The end result of this research will be improved health care to people in the underserved Appalachian community and the general population. Investigators at each institution are committed to the success of the network both in trial enrollment and in leadership roles.

PI_NAMEs: BADHWAR, VINAY ;KRON, IRVING L.;YOUNT, KENAN  (contact)

PROGRAM_OFFICER_NAME: BURKE, CATHERINE

PROJECT_TERMS: Adult;Appalachian Region;Area;Blood Vessels;burden of illness;Cardiac;Cardiac Surgery procedures;Cardiology;Cardiovascular Diseases;Cardiovascular Surgical Procedures;Cardiovascular system;Caring;clinical care;clinical center;clinical development;Clinical Research;Clinical Skills;clinical translation;clinical trial enrollment;Clinical Trials;Clinical Trials Network;Collaborations;Communities;cost effective;design;Development;Educational process of instructing;Enrollment;Ensure;experience;Funding;Future;General Population;Goals;Health;health disparity;Healthcare;Heart;Heart failure;imager;implementation research;implementation science;improved;Industry;Infrastructure;innovation;Institution;interest;Investigation;Investments;Journals;Leadership;Link;medical specialties;Medicine;Mentors;Mission;Modeling;National Institute of Neurological Disorders and Stroke;Neurologist;Neurology;next generation;notch protein;novel;novel strategies;Operative Surgical Procedures;Outcome;participant enrollment;patient population;patient retention;Patients;Persons;Population;Positioning Attribute;Procedures;Productivity;Program Development;programs;Protocol Compliance;protocol development;Publications;Quality of Care;Recording of previous events;Records;recruit;Research;Research Infrastructure;Research Personnel;Research Subject Recruitments;Resources;Rest;Robotics;Role;Rural;Rural Community;Services;Site;skill acquisition;skills;Societies;socioeconomics;success;Surgeon;Textiles;Thoracic Surgical Procedures;Training;Training Programs;Translational Research;Translations;Travel;trial design;trial enrollment;underserved community;Underserved Population;Universities;Virginia;West Virginia

PROJECT_TITLE: Cardiothoracic Surgical Trials Network Linked Clinical Research Centers for Virginia and West Virginia


NIH_SPENDING_CATS: Clinical Research;Hematology

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Blood platelets play a critical role in stimulating clot formation and repairing vascular injury. Although platelet infusion improves certain life-threatening conditions, we do not know the details of how platelets are formed. Studies proposed in this application will advance our understanding of blood platelet production and may lead to new or improved therapies to treat low platelet count.

PI_NAMEs: ITALIANO, JOSEPH E (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Acceleration;Actins;Alpha Granule;angiogenesis;base;Biogenesis;Biology;Biomedical Engineering;Blood;Blood Platelets;Blood Vessels;Bone Marrow;Cells;Centrosome;chemotherapy;Clinical;Coagulation Process;Cytoplasm;Cytoskeleton;Data;Deposition;Dose;Dysmyelopoietic Syndromes;Endothelium;experience;Genetic Diseases;Hemostatic function;Image Analysis;Immune;Immunity;improved;Inflammation;Infusion procedures;Investigation;Isomerase;Knowledge;Laboratories;Leadership;Life;Mechanics;Megakaryocytes;Mentorship;Microfluidics;Microscopy;Microtubules;Molecular Target;Motor;new therapeutic target;novel;Operative Surgical Procedures;Organelles;Pathway Analysis;Patients;Penetration;Pharmaceutical Preparations;Physiological;Platelet Count measurement;Play;precursor cell;Process;Production;programs;Regulation;repaired;response;Role;Scientist;Signal Pathway;small molecule;Structure;Sulfhydryl Compounds;Testing;theories;Therapeutic;Thrombocytopenia;Thrombocytopenic Purpura;Time;vascular injury

PROJECT_TITLE: The Centrosome as a master controller of platelet production.


NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative The stem cells that maintain sperm production in mammals are controlled by chemical signals from the surrounding environment in the testicle. This study addresses how these signals are interpreted and processed appropriately inside the cells. The ultimate goal is to understand how abnormal genes form within these stem cells, leading to disorders in children.

PI_NAMEs: EVANS, TODD R (contact);LIU, YING

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Address;Adult;age related;age-related disease;Aging;Alleles;Apert syndrome;Behavior;behavioral phenotyping;Biochemical;cell behavior;Cell Culture System;Cell Nucleus;Cell Surface Receptors;cell type;Cells;Chemicals;Child;Clone Cells;craniofacial disorder;Cytoplasm;Data;de novo mutation;Detection;detection method;Disease;Engineering;Environment;enzyme substrate;experimental study;extracellular;FGFR2 gene;Fibroblast Growth Factor;Fibroblast Growth Factor Receptors;fitness;fluorophore;gain of function mutation;Gene Abnormality;gene product;Genes;Genetic;Genotype;Germ Cells;glial cell-line derived neurotrophic factor;Goals;Growth Factor;Homeostasis;Hour;improved;Link;Literature;Mammals;MAP Kinase Gene;Maps;Measurement;Measures;Mediating;MEKs;Methodological Studies;Methodology;Methods;Modality;Monitor;Mus;mutant;Mutation;Noonan Syndrome;novel;offspring;Output;Paternal Age;Pathogenesis;Pathogenicity;Pathway interactions;Pattern;pharmacologic;phase change;Phenotype;Phosphotransferases;PI3K/AKT;Population;Population Study;Process;Production;Proliferating;PTPN11 gene;Ras/Raf;receptor;Receptor Protein-Tyrosine Kinases;Reporter;response;Role;self-renewal;Signal Pathway;Signal Transduction;Somatic Cell;sperm cell;stem cells;Techniques;Technology;technology platform;temporal measurement;Testis;Time;transmission process;Variant;Western Blotting

PROJECT_TITLE: Methods for detection of dynamic intracellular signals in single adult spermatogonial stem cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-L(02)M]


ORG_CITY: DOVER

ORG_NAME: DELAWARE STATE UNIVERSITY

ORG_STATE: DE

PHR: Public Health Relevance Today’s biomedical researchers represent the backbone of innovation that improves public health nationwide. However, they have little resemblance to the overall diverse populations they are part of, causing increases in disparities in health access and outcomes. The proposed project to establish a U-RISE site at Delaware State University (DSU) will promote diversity of the new workforce in biomedical research. Being a Historically Black University, DSU is well positioned to significantly contribute towards this goal as its undergraduate student population is about 80% minority, mostly underrepresented in diverse STEM fields.

PI_NAMEs: BOUKARI, HACENE ;MILETTI, KARL E. (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Academic support;Bachelor's Degree;Biomedical Research;career;catalyst;Communities;Critical Thinking;cultural competence;Delaware;design;Development;Discipline;Doctor of Medicine;Doctor of Philosophy;Educational workshop;Enrollment;Ensure;ethnic minority population;experience;Faculty;graduate school;Graduation Rates;Grant;Historically Black Colleges and Universities;implicit bias;Institution;Internships;Intervention;Knowledge;Literature;member;Mentors;programs;racial minority population;Research;Research Training;Self Efficacy;Series;Site;skill acquisition;skills;STEM field;STEM student;student training;Students;success;summer research;Training;Training and Education;Training Programs;undergraduate research experience;undergraduate student;Universities;university student

PROJECT_TITLE: U-RISE at Delaware State University: Student Training in Academic Research

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE/RELEVANCE TO PUBLIC HEALTH Survival of all neonates has dramatically improved, particularly those born less than 1,000 grams; therefore, proven, cost-effective approaches to further reduce significant morbidities are essential to infants’ long-term health, and to society. Rigorous and reproducible multi-center trials with diverse participants are necessary in order to effectively treat the general neonatal population. The Utah Center is ready to continue as a leading member of the NICHD Neonatal Research Network, the world’s premier neonatal clinical trials group.

PI_NAMEs: OHLS, ROBIN K (contact)

PROJECT_TERMS: 7 year old;Address;Admission activity;Age;Ancillary Study;Appointment;Beds;Bilirubin;Birth Rate;Certification;Clinic;clinical center;Clinical Trials;Clinical Trials Cooperative Group;Clinical Trials Design;Collaborations;Committee Members;Communities;cost effective;Country;data sharing;design;Development;Elements;Encephalopathies;Enrollment;Evaluation;experience;extend lifespan;Extremely Low Birth Weight Infant;Faculty;follow-up;Funding;Future;Geography;Gestational Age;Goals;Health;Health Sciences;Healthcare;Hemoglobin;high risk;High-Risk Pregnancy;Hospitals;Human Resources;Human Subject Research;improved;Infant;Institutional Review Boards;International;Iron;Joints;kindergarten;Lead;Leadership;Life;Manuscripts;Maternal-Fetal Medicine Units Network;Medical center;member;Morbidity - disease rate;Multicenter Neonatal Research Network;Multicenter Studies;Multicenter Trials;National Heart, Lung, and Blood Institute;National Institute of Child Health and Human Development;Neonatal;neonate;Network Infrastructure;Neurodevelopmental Disability;New Mexico;Newborn Infant;Outcome;Participant;patient population;Patient Recruitments;Pediatric Hospitals;Philadelphia;Physician Executives;Population;Population Study;Premature Infant;primary outcome;Principal Investigator;Productivity;programs;Protocols documentation;Public Health;Qualifying;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Reproducibility;Research;Research Design;Research Infrastructure;Research Personnel;research study;Reticulocytes;Robin bird;Role;School-Age Population;Seminal;Site;skills;Societies;Survival Rate;System;United States National Institutes of Health;Universities;Utah;Writing

PROJECT_TITLE: NICHD Cooperative Multicenter Neonatal Research Network - Utah Center


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Hematology;Mental Health;Neurosciences

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Chronic stress-induced changes in cerebral blood flow and oxygen supply affect brain physiology, but molecular and cellular mechanisms are not fully understood. We will investigate neuronal hemoglobin, an oxygen-carrying protein, and hemoglobin-regulated pathways in a specific type of neurons as an immediate target of chronic stress-affected cerebrovascular dysfunction. The proposed research could yield a high impact outcome by uncovering a novel stress mechanism potentially relevant to mental health and brain disorders.

PI_NAMEs: KIM, YONG  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Affect;Affinity Chromatography;alpha(A) globin;Angiotensin-Converting Enzyme Inhibitors;Anti-Hypertensive Agents;Behavior;Behavioral;Behavioral Assay;behavioral outcome;behavioral response;Bioinformatics;biological adaptation to stress;Blood Vessels;blood-brain barrier disruption;Brain;brain cell;Brain Diseases;Brain region;Captopril;cell type;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;Chronic;Chronic stress;Cognition;CRISPR/Cas technology;Data;differential expression;disease model;environmental stressor;Erythrocytes;Future;Genes;Goals;Hemoglobin;Hemorrhage;Hippocampus;Homeostasis;Hypertension;Immunohistochemistry;Interneurons;Knock-out;Measures;Mental Health;Metabolic;Mitochondria;Modeling;Molecular;Mus;Mutation;Neurons;novel;Outcome;Oxidation-Reduction;Oxidative Phosphorylation;Oxidative Stress;Oxygen;Parvalbumins;Pathway interactions;Physiology;Predisposition;Proteins;Publishing;Research;response;Ribosomes;Role;Sickle Cell Anemia;Signal Transduction;social defeat;Stress;Techniques;Tissues;tool;transcriptome sequencing;Transgenic Mice;Translating;Vascular Diseases;vector

PROJECT_TITLE: Role of neuronal hemoglobin in chronic stress-induced mitochondrial adaptation in hippocampal PV interneurons


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Rehabilitation;Rural Health;Social Determinants of Health

ORG_CITY: LEXINGTON

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE We aim to use a 2x2 factorial design to test an acceptable and feasible peer support evidence-based intervention (EBI)—peer health coaching—to determine the preliminary effectiveness of different implementation strategies, as well as the overall EBI, at promoting self-care behaviors and improving glycemic control among older adults with type 2 diabetes living in Appalachian Kentucky. The main components of the factorial design will be how peer coaches are selected for participants (self-selected vs matched) and frequency of contact with coach (once per week vs every 2 weeks). Guided by the Practical, Robust Implementation and Sustainability Model (PRISM), we will collect quantitative and qualitative data to assess PRISM domains and give context to both anticipated and unanticipated EBI adaptations.

PI_NAMEs: KRUSE-DIEHR, AARON ;SMALLS, BRITTANY L. (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Age;Appalachian Region;Behavior;Clinical;Clinical Trials;Communities;Community Health;cost;Data;design;diabetes self-management;Diagnosis;Dimensions;Disease;Education;Effectiveness;Emotional;Ensure;Environmental Risk Factor;Evidence based intervention;Familiarity;Feedback;Frequencies;General Population;glycemic control;Glycosylated hemoglobin A;Goals;Health;human old age (65+);implementation evaluation;implementation outcomes;implementation strategy;improved;Individual;Intervention;intervention cost;Kentucky;Literature;Measures;Mission;Modeling;Monitor;Morbidity - disease rate;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;older adult;Outcome;Overutilization of Health Services;Participant;peer;peer coaching;peer support;post intervention;Practical Robust Implementation and Sustainability Model;Prevalence;primary outcome;Process;psychosocial;Psychosocial Factor;psychosocial outcome;Questionnaires;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Resources;response;Rural;Rural Appalachia;Rural Community;rural dwellers;rural residence;Self Care;service organization;skills;social;Social support;Source;Structure;Testing;trustworthiness;Vulnerable Populations

PROJECT_TITLE: Older Adults Using Social Support to Improve Self-Care (OASIS): Adaption, Implementation, and Feasibility of Peer Support for Older Adults with T2DM in Appalachia

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lung;Racial and Ethnic Minority Health Research;Rare Diseases;Sarcoidosis;Tuberculosis

ORG_CITY: NASHVILLE

ORG_NAME: MEHARRY MEDICAL COLLEGE

ORG_STATE: TN

PHR: PROJECT NARRATIVE: Sarcoidosis is a multi-organ granulomatous disease of unknown etiology, most commonly affecting the lungs, which may progress to pulmonary fibrosis. This project will use biospecimens from the NHLBI biorepository (BioLINCC) to test the hypothesis that PLA2R loss-of-function is a monogenic cause of sarcoidosis among African-Americans from the “ACCESS” (A Case Controlled Etiologic Study of Sarcoidosis) cohort.

PI_NAMEs: BORZA, DORIN-BOGDAN  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Affect;African American population;African American Women;African ancestry;American;Antibodies;Antigens;Autoantibodies;Autoantigens;Autoimmune;biobank;Biological;Biological Process;Candidate Disease Gene;case control;Chronic;cohort;Development;Disease;DNA;Environmental Risk Factor;Epithelial Cells;Etiology;Family;Genes;Genetic;genetic architecture;genetic association;genetic variant;Goals;Granulomatous disease;health disparity;high risk;Human;Human Genetics;Immune;innovation;insight;Integral Membrane Protein;Kidney;Kidney Diseases;latent infection;loss of function;Lung;mannose receptor;Mediating;Membranous Glomerulonephritis;mycobacterial;Mycobacterium tuberculosis;National Heart, Lung, and Blood Institute;Natural Immunity;novel;Organ;pathogenic autoantibodies;Pathway interactions;phenome;Phenotype;Phospholipase A2;Plasma;Predisposition;Proxy;Pulmonary Fibrosis;receptor;Research;Research Project Grants;Resources;Risk;Role;Sarcoidosis;Serology;Specimen;Testing;tool;Tuberculosis;Universities;Validation;Variant

PROJECT_TITLE: PLA2R1 Loss-of-Function: A Monogenic Cause of Sarcoidosis in African-Americans in the ACCESS Cohort


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

ORG_STATE: CO

PHR: Mild traumatic brain injuries (mTBI) were commonly sustained among those who served in the recent conflicts and are associated with increased rates of mental health disorders, including posttraumatic stress disorder (PTSD). Symptom overlap between mTBI and mental health conditions can result in diagnostic challenges and impact understanding of long-term prognosis. To remedy this, we along with our collaborators will create a unified longitudinal dataset to examine associations between physiologic biosignals/functional measures and mental health outcomes/conditions (e.g., symptoms, suicidal thoughts and behaviors). This dataset will include combined measures from the existing Long-Term Impact of Military Brain Injury (LIMBIC) and Translational Research Center for TBI and Stress Disorders (TRACTS) protocols. Initial findings from this proposed effort will be foundational for subsequent inquiry focused on enhancing diagnostic and prognostic efforts to improve brain health and psychosocial functioning among Veterans living with mTBI and mental health conditions.

PI_NAMEs: BRENNER, LISA A (contact)

PROJECT_TERMS: advanced analytics;Afghanistan;Alcohol consumption;alcohol misuse;Algorithms;Anxiety;Behavioral;Biological Markers;Brain;brain health;Brain Injuries;Caring;Center for Translational Science Activities;Clinical;cohort;Collaborations;combat;comorbidity;computerized;coping;Data;Data Analyses;Data Collection;data harmonization;Data Set;Development;Diagnosis;Diagnostic;Differential Diagnosis;Electroencephalography;Ensure;Etiology;Factor Analysis;Feeling suicidal;Freedom;Funding;Goals;health assessment;high risk;improved;Injury;Iraq;Link;longitudinal dataset;Machine Learning;Measures;Medicine;member;Mental Depression;Mental disorders;Mental Health;Methodology;mild traumatic brain injury;Military Personnel;multimodality;multiple datasets;operation;Outcome;personalized approach;personalized care;physical conditioning;Physiological;Post-Concussion Syndrome;Post-Traumatic Stress Disorders;precision medicine;Prognosis;prognostic;prospective;Protocols documentation;psychiatric comorbidity;psychosocial;Recording of previous events;Reporting;Risk;Severities;stress disorder;suicidal behavior;suicidal risk;Suicide;Suicide prevention;suicide rate;Symptom Burden;Symptoms;Techniques;Veterans;Veterans Health Administration;visual tracking;Work

PROJECT_TITLE: Total Brain Diagnostics (TBD): Analyzing the Impact of Functional Symptom and Clinical Measures on Co-Morbid Mental Health Conditions after TBI

STUDY_SECTION: RRDB

STUDY_SECTION_NAME: Brain Injury[RRDB]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Social Determinants of Health

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

PHR: NARRATIVE: KEEP: Kentucky Environmental Education Pipeline program will recruit and train undergraduate student researchers from historically marginalized populations for careers within the field of environmental health sciences. Key to the mentorship associated with this summer research opportunity program, we will offer access to specialized skills training sessions via ‘boot camps’ including a community-embedded air/soil sampling field trip with integrated report back organized and administered via the NIEHS funded Center for Integrative Environmental Health Sciences Community Outreach core. Faculty mentors and/or program directors will continue to provide career coaching and personalized mentorship until matriculation so that participants are fully integrated into an ongoing supportive community focused on degree completion, timely application to competitive graduate and professional school programs, and ultimately biomedical careers in environmental health sciences.

PI_NAMEs: ABOLINS-ABOLS, MIKUS ;CORBITT, CYNTHIA ;NEAL, RACHEL ELIZABETH (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: Abattoirs;Academic support;Air;Appalachian Region;Arts;Back;Biology;Biometry;Black race;bridge to the baccalaureate;cancer health disparity;Capital;career;Chemicals;Chemistry;Coal;cohort;college;Communities;Community Outreach;community partners;cost;County;Creativeness;Data;Degree Completion;Development;disabled;disadvantaged student;Discipline of Nursing;Dropout;economic disparity;Economics;Education;Enrollment;Environmental Health;Environmental Monitoring;Equity;Evaluation;Excision;experience;Exposure to;faculty mentor;Fellowship Program;field trip;Foundations;Funding;Goals;Health;Health Personnel;Health Sciences;Home;Huntington Disease;Incentives;Information Sciences;Infrastructure;innovation;Institution;Instruction;Justice;Kentucky;Latino;Link;Lived experience;manufacture;marginalized community;marginalized population;matriculation;Medical Students;Medicine;meetings;Mental Health;Mentors;Mentorship;Methodology;National Institute of Environmental Health Sciences;Ohio;Organization and Administration;Outcome;Participant;Pollution;Postdoctoral Fellow;posters;programs;Public Health;recruit;Reporting;Research;Research Personnel;Research Training;Running;Sampling;satisfaction;Schools;Science;Scientist;Site;skills;skills training;Societies;soil sampling;Statistical Data Interpretation;STEM field;STEM program;STEM student;Structure;Students;summer research;Superfund;superfund site;technical college;Toxicology;Training;Training and Education;Training Programs;transfer student;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Students;Universities;Vocational Guidance

PROJECT_TITLE: KEEP: Kentucky Environmental Education Pipeline, A program to retain a diverse and equitable scientific trainee pipeline

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 BWD-W (25)]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Chronic Pain;Eye Disease and Disorders of Vision;Neurosciences;Pain Research

ORG_CITY: BRIDGEWATER

ORG_NAME: VYLUMA INC.

PHR: NARRATIVE Eye injuries are common, and the cornea in the eye is very painful when injured. Nevertheless, there are currently no approved treatments specifically for corneal pain, and those treatment options that are used are associated with significant side effects. The goal of this study is to develop a safe and effective treatment for acute corneal pain that can be administered as eye drops.

PI_NAMEs: FONG, TUNG  (contact);SOPPIMATH, KUMARESH

PROJECT_TERMS: Acceleration;Acute;Adverse effects;Affect;Analgesics;Animals;Area Under Curve;Binding;Blindness;Capsaicin;Cataract;Chemicals;Circulation;Clinical;clinical practice;commercialization;Control Groups;Cornea;corneal epithelial wound healing;corneal epithelium;Corneal pain;Data;Development;Dose;drug efficacy;Drug Kinetics;effective therapy;Eye;Eye Injuries;Eyedrops;FDA approved;Formulation;Functional disorder;Generations;Goals;injured;Injury;innovation;Literature;melting;Modeling;N-Methyl-D-Aspartate Receptors;Non-Steroidal Anti-Inflammatory Agents;novel;ocular pain;Oral;Oryctolagus cuniculus;Osmolar Concentration;Pain;Pain Measurement;pain model;painful neuropathy;Penetration;Perforation;Performance;Persons;Pharmaceutical Preparations;Pharmacodynamics;Pharmacologic Substance;Pharmacotherapy;Phase;phase 1 study;Physiologic Intraocular Pressure;pre-clinical;pregabalin;Process;Rattus;response;Safety;salt balance;Serum;side effect;Solid;Solubility;Steroids;Time;Tissues;Topical application;treatment group;United States;Viscosity

PROJECT_TITLE: Development of a safe and effective topically administered pharmacotherapy to treat acute corneal pain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-M (12)]


NIH_SPENDING_CATS: Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE/ PUBLIC HEALTH RELEVANCE STATEMENT This quasi-experimental, longitudinal study will (a) examine the influence of state and federal nutrition policy interventions for schools on child obesity prevalence and related disparities among diverse Asian/PI subgroups; and (b) determine the extent to which community food environments modify the policy influences on obesity. The study will generate new evidence on the effectiveness of current nutrition policy interventions to prevent obesity among population groups who have been severely understudied in obesity prevention research. Findings from this study will inform population-wide strategies to prevent obesity and promote children’s healthy body weight among diverse Asian/PI populations.

PI_NAMEs: SANCHEZ, BRISA N (contact);SANCHEZ-VAZNAUGH, EMMA V.

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Asia;Asian;Asian Americans;Asian Indian;Asian population;Beverages;Body mass index;Body Weight;built environment;California;Cambodian;Candy;Child;Chinese;Chronic Disease;Communities;Consumption;cost;Data;Data Reporting;design;Diabetes Mellitus;Diet;Dietary Intervention;disadvantaged student;Disparity;Disparity population;disparity reduction;effective intervention;Effectiveness;Environment;Ethnic Origin;Ethnic Population;evidence base;Fatty acid glycerol esters;federal policy;Filipino;Food;food environment;food quality;Future;Geographic state;Guamanian;Health Food;health goals;high risk;improved;Individual;Interruption;Intervention;Japanese;Koreans;Laws;Link;longitudinal analysis;Longitudinal Studies;Masks;Measures;Methodology;Methods;Native Hawaiian;nutrition;Nutrition Policy;Nutritional;Obesity;Obesity associated disease;obesity in children;obesity prevention;obesity risk;Pacific Islander;Pacific Islands;peer;Play;Policies;Population;Population Group;Prevalence;prevent;Prevention Research;Primary Prevention;Public Health;public health relevance;Publishing;Quasi-experiment;Race;Reporting;Research;Research Priority;Samoan;School-Age Population;Schools;Science;Series;socioeconomic disadvantage;socioeconomics;soft drink;Strategic Planning;Students;Subgroup;sugar;Time;United States Department of Agriculture;United States National Institutes of Health;Variant;Vietnamese;Youth

PROJECT_TITLE: Population-level interventions and community environment effects on obesity among diverse Asian American ethnic subgroups


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Gene Therapy;Genetics;Immunotherapy;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: MENLO PARK

ORG_NAME: SRI INTERNATIONAL

PHR: PROJECT NARRATIVE This research will lead to a device that can selectively culture a sub-population of chemotactically active therapeutic cells for preferentially migrating to the tumor microenvironment and sparing the healthy tissues of side effects. It is relevant to public health because it will enable new treatment for solid tumors. This is relevant to the NCI’s mission because the proposed bioreactor will be broadly applicable to manufacture multiple types of cell therapies (T cells, NK cell, macrophages, iPS cells) that can be used for targeting various malignancies.

PI_NAMEs: LIU, XIAOHE  (contact)

PROGRAM_OFFICER_NAME: COUCH, JENNIFER A

PROJECT_TERMS: Adverse event;Affinity;Antigen Targeting;Antigens;Bioreactors;cancer cell;CCL19 gene;Cell Line;cell motility;Cell Survival;Cell Therapy;cell type;Cells;Cellular immunotherapy;Cessation of life;chemokine;chemokine receptor;chimeric antigen receptor natural killer cells;chimeric antigen receptor T cells;Clinical;Clinical Trials;cost;Cytolysis;Data;density;design;Development;Devices;Dose;Engineering;Epithelial ovarian cancer;exhaustion;Extravasation;Hydrogels;Immune;Immune system;Immunocompetent;improved;induced pluripotent stem cell;Infusion procedures;innovation;Intervention;Logic;Macrophage;Malignant Neoplasms;Manuals;manufacture;manufacturing cost;manufacturing scale-up;manufacturing technology;Methodology;migration;Mission;MSLN gene;Mus;Natural Killer Cells;new technology;Outcome;Output;Patients;Polymers;Porosity;pre-clinical therapy;Procedures;Process;Production;Protocols documentation;prototype;Public Health;RANTES;receptor;Research;response;Safety;side effect;Site;Solid Neoplasm;Surface;System;T-Lymphocyte;Technology;Testing;Therapeutic;Thick;Tissues;Toxic effect;Treatment outcome;tumor;Tumor Antigens;tumor microenvironment

PROJECT_TITLE: Bioreactor for Manufacturing Chemotactically Competent Immune Cell Therapies

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-D (O1)]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative An abnormal number of chromosomes and associated copy number variations of the genetic material are hallmarks of cancer. However, how chromosome segregation errors and the resulting aneuploidy contribute to cancer initiation, malignancy, evolution, and heterogeneity is poorly understood. The goal of this project is to develop innovative imaging and optogenetics technology to observe and manipulate chromosome segregation dynamics with high spatial and temporal accuracy in patient-derived cancer organoids to ask fundamental questions about the complex relationship between aneuploidy and cancer and inform development of new and personalized therapies.

PI_NAMEs: WITTMANN, TORSTEN  (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: 3-Dimensional;Acute;Address;Affect;Aneuploidy;aptamer;Bar Codes;Biological Models;Breast Cancer Model;cancer cell;cancer initiation;Cancer Model;cancer therapy;carcinogenesis;Carcinoma;cell behavior;Cell division;Cell Nucleus;Cells;Characteristics;Chromosomal Instability;Chromosome Arm;chromosome loss;chromosome missegregation;chromosome number abnormality;Chromosome Segregation;Chromosomes;chromothripsis;Clinical;Complex;Copy Number Polymorphism;Cytokinesis;deep learning;design;Development;Dimerization;Diploidy;DNA;DNA Sequence;Drug resistance;Dyes;Effectiveness;endonuclease;Engineering;Event;Evolution;Exhibits;expectation;Exposure to;F-Actin;Fluorescence;Generations;Genetic Materials;genetic profiling;Goals;Guide RNA;Heterogeneity;Histones;Human Genome;Image;Image Analysis;Immobilization;in vitro Model;Individual;innovation;Interphase;Karyotype determination procedure;Kinetochores;Label;learning network;Light;Malignant Breast Neoplasm;Malignant Neoplasms;mammary epithelium;MCF10A cells;Methods;micronucleus;Microscopy;Microtubules;Mitotic Chromosome;Mitotic spindle;Molecular;Mutation;nano;neoplastic cell;Normal Cell;Normal tissue morphology;novel;novel therapeutics;optogenetics;Organoids;Outcome;Pathway interactions;patient prognosis;Patients;Pattern;personalized medicine;personalized therapeutic;Phenotype;Pilot Projects;Population;prevent;Proliferating;Proteins;RNA;segregation;Solid;Sum;synthetic biology;Technology;Testing;therapeutic target;three-dimensional modeling;Training;tumor;tumor heterogeneity;tumorigenesis;Variant

PROJECT_TITLE: Quantitative analysis and manipulation of chromosome dynamics in cancer organoids


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: Project Narrative The Gordon Research Conference (GRC) and accompanying Gordon Research Seminar (GRS) Barriers of the CNS will provide a platform for senior and junior, academic and non-academic, and basic and clinical researchers from around the world to improve their understanding of the complex cellular and molecular mechanisms regulating neural barrier integrity in health and disease. The brain/neural barriers, in their function to protect the central nervous system (CNS) from neurotoxic compounds and to regulate the CNS immune privilege, also block delivery of drugs to the CNS, thus hindering diagnosis and treatment of neurological disorders. The Barriers of the CNS 2024 GRS and GRC are dedicated to providing a unique trans-disciplinary environment giving attendees the opportunity to discuss broadly to bridge knowledge gaps in the field that will help overcome the unmet need for the development of diagnostic or therapeutic tools for diseases in the CNS.

PI_NAMEs: WILLIAMS, DIONNA WHITNEY (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Academia;Address;Age related macular degeneration;Alzheimer's Disease;Antibodies;Arachnoid mater;Area;bench to bedside;Bioinformatics;Biology;Biomedical Engineering;Blood;Blood - brain barrier anatomy;Blood Circulation;Blood-Retinal Barrier;Brain;Brain Neoplasms;career;cell type;Cells;Central Nervous System;Central Nervous System Agents;Central Nervous System Diseases;Clinical;cohesion;Collaborations;college;Complex;Computer Models;Dedications;Development;Diabetic Retinopathy;Diagnosis;Diagnostic;diagnostic development;Disease;Drug Delivery Systems;Endothelium;Environment;Epithelium;Equilibrium;Feedback;Fostering;Functional disorder;Funding;gene therapy;gene-targeted therapy;Genes;Genetic;Genetic Diseases;Glioma;Goals;Growth and Development function;Health;Homeostasis;Immune system;improved;in vitro Model;Industry;innovation;insight;interest;International;intravital microscopy;Ion Transport;Knowledge;knowledge translation;Laboratories;Lead;Link;macromolecule;Malignant Neoplasms;mathematical model;Measures;meetings;Mentors;Methods;Molecular;Molecular Genetics;multidisciplinary;Nervous System Disorder;neural;neuroinflammation;neuroprotection;neuropsychiatric disorder;neurotoxic;neurovascular unit;New Hampshire;next generation;novel;novel strategies;novel therapeutics;Organoids;palliative;Participant;Pathogenesis;peer;Pharmaceutical Preparations;Physiology;posters;prevent;programs;Public Health;Regulation;Request for Applications;Request for Proposals;Research;Research Methodology;Research Personnel;Role;Science;Scientist;Senior Scientist;Severity of illness;Small Interfering RNA;symposium;Therapeutic;Time;tool;trafficking

PROJECT_TITLE: 2024 Barriers of the CNS Gordon Research Conference and Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-P (11)]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Clinical Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE Human labor is a highly inflammatory event, but what causes it to start is unclear. We have found that cell-free fetal DNA (cffDNA) can activate the mother’s immune system and promote the transition towards labor. This proposal aims to understand what about cffDNA makes it activate immune cells and whether we can block the inflammation caused by cffDNA, which is particularly important for preventing preterm birth.

PI_NAMEs: SORENSON, RAINI ADAIR (contact)

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: 37 weeks gestation;Address;Allografting;Attenuated;Automobile Driving;Award;Birth;Blood;Blood Circulation;CD14 gene;Cell Death;cell free DNA;cell free fetal DNA;Cell Separation;Cells;Cellular Infiltration;Cessation of life;Childhood;Clinical;cytokine;Development;DNA;DNA Sequence;DNA sequencing;Endothelial Cells;Epigenetic Process;Event;Faculty;fetal;Goals;Hour;Human;Immune;immune activation;Immune system;Immunologics;Immunology;improved;improved outcome;In Vitro;infant morbidity/mortality;Infant Mortality;infant outcome;Inflammation;Inflammatory;inhibitor;Knowledge;Lead;leukocyte activation;Live Birth;maternal immune system;Mediating;Mentors;Molecular;monocyte;Newborn Infant;novel;Pathogenesis;Pathologic;Pathway interactions;Pattern;Pattern recognition receptor;peripheral blood;Physiological Processes;Physiology;Placenta;Positioning Attribute;Postdoctoral Fellow;predictive test;Pregnancy;pregnant;premature;Premature Birth;prevent;Prevention;Process;Production;Property;Proteins;Research;Role;Signal Pathway;Signal Transduction;small molecule;small molecule inhibitor;Sterility;Stimulator of Interferon Genes;Testing;Therapeutic;Training;trophoblast;United States;Up-Regulation;Uterine Contraction;Uterus;Woman

PROJECT_TITLE: Evaluating the mechanisms of cell free fetal DNA signaling in the promotion of labor

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F06-L (20)]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: BENAROYA RESEARCH INST AT VIRGINIA MASON

ORG_STATE: WA

PHR: Project Narrative The production of IL-2 is tightly regulated and few CD4+ T cells maintain IL-2 expression. The importance and characteristics of these cells during CNS autoimmunity has not been determined. In this proposal, we will use novel tools to characterize IL-2+ CD4+ T cells during experimental autoimmune encephalomyelitis (EAE) and address their role in disease progression.

PI_NAMEs: BETTELLI, ESTELLE  (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Address;Adoptive Transfer;Animal Model;Autoimmune Diseases;Autoimmunity;biomarker identification;CD4 Positive T Lymphocytes;Cell Physiology;Cells;Central Nervous System;Characteristics;Chronic;CNS autoimmunity;cytokine;Data;Demyelinations;Development;Disease;Disease Progression;Equilibrium;Experimental Autoimmune Encephalomyelitis;experimental study;Frequencies;Gene Expression Profile;Genetic study;Geography;Grant;Granulocyte-Macrophage Colony-Stimulating Factor;Growth;Homeostasis;Human Genetics;IL17 gene;Immunity;Inflammation;insight;Interferon Type II;Interleukin-2;Location;lymph nodes;lymphoid organ;Maintenance;Maps;Modeling;Multiple Sclerosis;Mus;Myelin;Nerve Degeneration;novel;Onset of illness;Pathogenicity;Pathway interactions;Phase;Population;prevent;Production;Proliferating;Publishing;recruit;Regulation;Regulatory T-Lymphocyte;Remission Induction;Role;Signal Transduction;single-cell RNA sequencing;Source;STAT1 gene;T-Lymphocyte;Testing;Tissues;tool;transcription factor

PROJECT_TITLE: Modulation of pathogenic T cells in EAE

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]