NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Estrogen;Menopause;Neurodegenerative;Neurosciences;Nutrition;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

ORG_CITY: NEW ORLEANS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Overall Project Narrative The Program Project will determine if and how estrogens interact with cardiovascular and metabolic health to impact the brain and cognitive aging. Understanding conditions under which administration of estrogens are beneficial or harmful is critical to developing a personalized approach in recommendations for use of menopausal hormone therapy in women.

PI_NAMEs: DANIEL, JILL M (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Affect;age related;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Behavior;blood glucose regulation;Blood Vessels;Brain;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;Cardiovascular system;Clinical Data;Cognition;Cognition Disorders;Cognitive;Cognitive aging;cognitive change;cognitive function;Cyclophosphamide;design;Development;Diet;Disease;Ensure;ESR1 gene;Estradiol;Estrogen Receptors;Estrogen Therapy;Estrogens;experimental study;Female;Functional disorder;Goals;Health;Health Status;High Fat Diet;Hippocampus;Homeostasis;hormone therapy;Hormones;Hypertension;Impaired cognition;Impairment;Incidence;Insulin Resistance;Investigation;Leadership;Long-Term Potentiation;Measurement;Memory;menopausal hormone therapy;Menopause;Metabolic;Metabolic syndrome;middle age;midlife estradiol;Modeling;Molecular;multicatalytic endopeptidase complex;Nerve Degeneration;neuroprotection;neurovascular coupling;Non-Insulin-Dependent Diabetes Mellitus;NOS3 gene;Ovarian;personalized approach;Physiological;Pre-Clinical Model;preservation;Procedures;Process;Program Research Project Grants;programs;Recommendation;Regulation;Reproducibility of Results;Research;response;Risk Factors;Rodent Model;Signal Pathway;Synaptic plasticity;System;Testing;Ubiquitin;Variant;Vascular Dementia;Weight Gain;Woman

PROJECT_TITLE: Estrogens, Cardiometabolic Health, and Female Cognitive Aging


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: STANFORD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: C-DIAS OVERALL: PROJECT NARRATIVE In this revised P50 proposal, we envision a Center for Dissemination and Implementation At Stanford: C-DIAS. Public access to (reach) and routine delivery of (adoption) evidence-based addiction treatments are historic and persistent problems. Serving as an open, national and enduring resource, this unique Center of Excellence will integrate broad-based multi-disciplinary expertise, creatively develop expert capacity, advance the science of implementation, and promote the equitable sustainment of proven addiction treatments.

PI_NAMEs: MCGOVERN, MARK P (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: Acceleration;addiction;Address;Adoption;Area;Communities;Consultations;contingency management;cost;County;Creativeness;data harmonization;Dedications;design;Development;digital treatment;Disparity population;Dissemination and Implementation;dissemination science;Economic Models;Epidemic;Equity;evidence base;Evidence based treatment;Fellowship;Fostering;Funding;Geography;Goals;Health;health assessment;health care disparity;health economics;health equity;Health Policy;Health Services;Health Services Research;Health system;Healthcare Systems;human capital;implementation efforts;implementation evaluation;implementation research;implementation science;implementation strategy;improved;Individual;Intervention;Lead;Leadership;Link;Measures;Medicine;member;Mentorship;Methods;Modeling;multidisciplinary;National Institute of Drug Abuse;National Institute of Mental Health;novel;online resource;opioid use disorder;Outcome;overdose death;Overdose reduction;Patients;pharmacologic;Phase;Policy Maker;Preparation;primary care clinic;Privatization;psychosocial;Public Health;Reaction;Research;Research Institute;Research Project Grants;Resources;scale up;service delivery;Services;Standardization;standardize measure;stimulant use;Strategic Planning;Substance Use Disorder;success;synergism;System;Techniques;tool;Training and Education;Translating;Translations;treatment program;treatment services;Validation;Variant

PROJECT_TITLE: Transforming health equity rhetoric to rigor: Development and validation of a novel measure assessing health equity in implementation of health interventions


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: Boulder

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because dysfunction of membrane trafficking pathways to the lysosome are linked to genetic disease, and exploitations of these pathways are essential for the spread of HIV-1 and other viral pathogens. Membrane trafficking pathways to lysosomes use evolutionarily conserved mechanisms. Therefore, the proposed research is relevant to the mission of NIGMS in understanding biological processes as a foundation for advances in disease diagnosis, treatment, and prevention.

PI_NAMEs: ODORIZZI, CHARLES G (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Address;Biogenesis;Biological Process;biophysical analysis;career;Career Choice;career development;Cell Physiology;Cell Surface Receptors;Cells;Collaborations;design;Development Plans;Diagnostic;Disease;disease diagnosis;Endocytosis;Endosomes;Enzymes;experimental study;extracellular;Foundations;Functional disorder;Funding;Genetic;Genetic Diseases;Genetic Screening;Goals;HIV-1;Human;In Vitro;Infection;Integral Membrane Protein;interest;International;Learning;Link;Literature;Lumen of the Lysosome;Lysosomes;man;Mediating;Membrane;Mentors;Microscopy;Mission;model organism;Molecular;Mutation;National Institute of General Medical Sciences;novel;pathogen;pathogenic virus;Pathway interactions;Phase;Physiological;post-doctoral training;Prevention;Process;Productivity;Protein Analysis;Proteins;Proteomics;proteostasis;Public Health;Publishing;Reagent;receptor;reconstitution;Regulation;Research;Resolution;Role;Saccharomyces cerevisiae;Saccharomycetales;Science;Site;skills;Sorting;symposium;System;Techniques;Testing;tool;trafficking;Ubiquitin;Vesicle;vesicle transport;Vision;Work;Yeasts

PROJECT_TITLE: Membrane trafficking to lysosomeshttps://apps.era.nih.gov/gmii/manage/view.era?applId=11030651#

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(01)-Q]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Racial and Ethnic Minority Health Research

ORG_CITY: Aurora

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Project Narrative: Relevance of research to public health This project will investigate metabolic differences in the intermuscular adipose tissue (IMAT) secretome between obese Black and White participants before and after weight loss. Moreover, it will employ culturally sensitive strategies to recruit and retain Black participants. These findings are crucial for developing diabetes interventions and treatments tailored specifically for the Black population.

PI_NAMEs: BERGMAN, BRYAN C (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Address;adipokines;Adipose tissue;Bathing;Biopsy;Black American;black men;Black Populations;Black race;black women;Body fat;Body Weight decreased;caucasian American;Clinical Research;Communities;Cultural Sensitivity;cytokine;Data;Development;Diabetes Mellitus;Disease;Eicosanoids;Equity;experience;experimental study;Glucose Clamp;Goals;High Prevalence;Hyperinsulinism;improved;In Vitro;Individual;individualized medicine;Inflammation;Inflammatory;Insulin Resistance;insulin sensitivity;Intervention;K-Series Research Career Programs;Knowledge;lifestyle intervention;Link;Lipids;Literature;Magnetic Resonance Imaging;Marble;Measures;Mentors;Metabolic;Metabolic Diseases;Muscle;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;Obesity;Operative Surgical Procedures;Paracrine Communication;Parents;Participant;Persons;Population;prevent;Public Health;Race;racial difference;recruit;Research;response;Sampling;Scientist;Signal Transduction;Skeletal Muscle;subcutaneous;Surgeon;Techniques;Testing;therapy development;Trust;ultrasound;Visceral;weight loss intervention

PROJECT_TITLE: Effect of weight loss on intermuscular adipose tissue (IMAT) signaling

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ADMINISTERING_IC: PS

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STD AND TB PREVENTION

ORG_CITY: BALTIMORE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PI_NAMEs: GUILAMO-RAMOS, VINCENT M. (contact)

PROJECT_TITLE: Development and Evaluation of a Multilevel, Socio-Culturally Contextualized Digital Health Decision Intervention to Reduce Medical Mistrust and Improve Status-Neutral HIV Service Use among HLMSM


ADMINISTERING_IC: CE

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

ORG_CITY: LEXINGTON

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Given the promise of bystander programs to reduce youth sexual violence, we have used bystander theory to adapt an evidence-based program directed toward the prevention of commercial sexual exploitation and trafficking (CSE/T) of children (Priority Area 4). A statewide, middle-school based randomized controlled trial will be conducted in 32 Kentucky counties over 4 years with the primary goal of evaluating the effectiveness of our novel Bystander-informed See it Stop it (BiSiSi) program, as implemented among middle school staff as interventionists, to increase screening and identification of CSE/T in intervention versus attention control schools, in the short term years 0-2), and prevent CSAET in the longer term (year 3)

PI_NAMEs: COKER, ANN L (contact)

PROJECT_TITLE: CE-21-006: RCT to evaluate Bystander-informed See it Stop it (BiSiSi) to Prevent Child Sex Trafficking in Kentucky Middle Schools


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: CANANDAIGUA

ORG_NAME: VETERANS AFFAIRS, UNITED STATES DEPARTMENT OF

ORG_STATE: NY

PHR: The risk for suicide increases by nearly 50% in the first year that service members transition from the military to civilian life underscoring the need for effective strategies to facilitate help seeking among Veterans vulnerable to self-directed violence. Yet despite a great need for treatment, more than half of returning Veterans at risk for suicide do not initiate mental health services. VA has embarked on the regular use of communication campaigns as part of a public health approach designed to reach the larger Veteran population with messages promoting help seeking. However, what types of messages effectively change beliefs and behaviors for at-risk Veterans resistant to seek treatment is unclear. The main objective of this study is to develop and test the use of public messaging to increase treatment seeking among Veterans at risk for suicide and resistant to seek mental health care following separation from military service. This represents the first study to systematically develop public messaging strategies for populations at risk for suicide.

PI_NAMEs: KARRAS, ELIZABETH  (contact)

PROJECT_TERMS: 18 year old;2 arm randomized control trial;active duty;Audience Research;Behavior;behavioral response;Belief;Cellular Phone;Communication;Consent;Control Groups;cost;Data;Data Collection;design;Eligibility Determination;evidence base;Evidence based treatment;Exclusion Criteria;experience;Feeling suicidal;follow-up;Funding;Future;Goals;Head;help-seeking behavior;high risk;high risk population;Impairment;improved;inclusion criteria;Individual;innovation;Institutionalization;Intervention;Interview;iterative design;Life;Measures;Mental Health;Mental Health Services;Methodology;Methods;Military Personnel;military service;military veteran;Minority;mobile application;Observational Study;outreach;Ownership;Participant;peer;Performance;Planning Theory;Populations at Risk;portability;Predisposition;prevent;Process;Public Health;Randomized;recruit;repository;Research;Resistance;Risk;Sampling;screening;Self Direction;service member;service utilization;Services;smartphone application;suicidal behavior;suicidal risk;Suicide;Suicide prevention;suicide rate;Target Populations;Telephone;Testing;treatment services;verbal;Veterans;Violence;Waiting Lists;Woman;Work

PROJECT_TITLE: Public messaging to increase treatment seeking among Veterans at risk for suicide during transition from military service

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

ORG_STATE: MA

PHR: In this project we will examine Alzheimer’s disease (AD) genetic risk and its relationship to cognitive impairment in middle and old age to determine the extent to which effects of AD genetic risk are observable in advance of the onset of dementia. We will also evaluate whether AD genetic risk influences PTSD symptomatology in aging veterans. Finally, will look for evidence that combat trauma and traumatic brain injury (TBI) exacerbate the effects of AD genetic risk on AD. Early detection of AD risk has been noted as key to the identification of effective treatments for AD. Hence, this project has the potential to lead to better informed and more effective AD interventions. By examining how genetic factors interact with TBI and trauma we hope to pave the way for the development of diagnostic algorithms specifically tailored to a veteran population designed to identify those at risk for dementia.

PI_NAMEs: LOGUE, MARK W (contact)

PROJECT_TERMS: Age;Age of Onset;age related;Aging;Alzheimer's Disease;Alzheimer's disease risk;Brain region;Candidate Disease Gene;Cognitive;cognitive function;cognitive performance;cognitive testing;combat;combat trauma;comorbidity;Cox Proportional Hazards Models;Data;Dementia;dementia risk;design;detection method;Diagnosis;diagnostic algorithm;diagnostic development;Early Diagnosis;Early identification;Early treatment;effective therapy;Environment;Environmental Exposure;gene environment interaction;gene function;Genes;Genetic;Genetic Risk;genetic risk factor;genetic variant;genome wide association study;genome-wide;Genotype;human old age (65+);Impaired cognition;improved;Individual;interest;Intervention;Investigation;Late Onset Alzheimer Disease;Life Style;longitudinal design;Magnetic Resonance Imaging;Measures;Medical Records;Memory;Methods;middle age;mild cognitive impairment;mild traumatic brain injury;military trauma;military veteran;Molecular;Neurobehavioral Manifestations;Neurologic Effect;Onset of illness;Participant;Pathology;Patient Self-Report;Performance;Phenotype;polygenic risk score;Post-Traumatic Stress Disorders;Price;Protein Isoforms;Psychiatry;Recording of previous events;Risk;Risk Factors;risk variant;Sampling;Severities;Stress;Surveys;symptomatology;Symptoms;Testing;Thick;Trauma;trauma exposure;Traumatic Brain Injury;traumatic stress;Variant;Veterans

PROJECT_TITLE: Early Cognitive Impairment as a Function of Alzheimer’s Disease Genes and Trauma

STUDY_SECTION: SPLM

STUDY_SECTION_NAME: Special Initiatives - MVP Projects[SPLM]


ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

PHR: Cutaneous T cell Lymphoma (CTCL) is an indolent but life-threatening cancer of T lymphocytes that reside in the skin. One recent study using the VA Informatics and Computing database estimated a 6-8 fold higher incidence among Veterans than the general population. Although prognosis worsens with increasing disease stage, CTCL patients of all stages suffer from chronic skin inflammation that can produce unsightly or disfiguring skin lesions, itching, pain, and sleep disturbance that interfere with daily activities, and cause emotional distress. CTCL are often misdiagnosed as benign skin conditions, delaying appropriate therapies. The goal of the proposed studies is to have a positive effect on the health of Veterans by (1) identifying epigenetic and gene expression biomarkers that can improve diagnostic specificity in early disease, (2) increasing understanding of genetic dysregulation that promotes CTCL pathogenesis, and (3) overcoming barriers to progress in studies of skin-derived T cells.

PI_NAMEs: WONG, HENRY KEUNG (contact)

PROJECT_TERMS: Address;advanced disease;Affect;Benign;Binding Sites;Biological;Biological Assay;Biological Markers;biomarker identification;cancer cell;cancer genome;cell growth;Chemicals;Chronic;Clinical;combat;Complex;Cross-Sectional Studies;Cutaneous T-cell lymphoma;Data;Databases;demethylation;Development;Diagnosis;diagnostic biomarker;Diagnostic Specificity;Diagnostic tests;diagnostic value;differential expression;Disease;Disease Progression;DNA;DNA analysis;DNA Methylation;Early Diagnosis;Eczema;effective therapy;emotional distress;Enhancers;Enzymes;Epigenetic Process;epigenetic regulation;Etiology;Evolution;Experimental Models;experimental study;Exposure to;gain of function;Gene Abnormality;Gene Expression;Gene Expression Profiling;General Population;Genes;Genetic;Genetic Heterogeneity;Genetic Markers;genome-wide;Genomic Instability;Genomics;Goals;Grant;Health;Hydrocarbons;Hypermethylation;improved;Incidence;Indolent;Inflammation;Inflammatory;Informatics;insight;leukemia;Life;loss of function;Malignant - descriptor;Malignant Neoplasms;Maps;Methylation;methylation biomarker;methylome;Military Personnel;military veteran;Monitor;mRNA Expression;Mutation;Mycosis Fungoides;Nature;neoplastic;Neoplastic Cell Transformation;new therapeutic target;novel;Occupational;Oncogenic;overexpression;Pain;Pathogenesis;Pathogenicity;Pathway interactions;Patients;permissiveness;personalized medicine;Pesticides;prevent;Process;Prognosis;Prognostic Marker;promoter;Pruritus;Psoriasis;Publishing;Quality of life;Regulatory Element;Repression;Reproducibility;Research;Resolution;Rest;Risk;Risk Factors;Role;Services;Severity of illness;Sezary Syndrome;Signal Transduction;Site;Skin;skin lesion;Sleep disturbances;Study models;T-Cell Activation;T-Cell Lymphoma;T-Lymphocyte;Technology;Training;transcription factor;transcriptome;transcriptome sequencing;treatment strategy;tumor;Tumor Suppressor Genes;tumorigenesis;TWIST1 gene;Variant;Veterans

PROJECT_TITLE: Epigenetic Regulation of Differentially Expressed Genes in Cutaneous T Cell Lymphoma


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Project Narrative Public Health Relevance Statement How the collective action of distributed neural systems in the human visual pathway leads to our rich percept of the visual world is not well understood, and disorders of the circuits involved in perception, especially those involved in face and object recognition, can significantly impair normal social function. Understanding the neural computations that support human vision and their locations in the brain will offer valuable insights into the development of visual neuro-prostheses, guidance for neurosurgery, and strategies for recovery from brain damage.

PI_NAMEs: RATAN MURTY, N APURVA  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Address;Algorithms;analytical method;Animals;Area;Behavior;Brain;Brain Injuries;Brain region;Categories;Cognition;cognitive ability;cohort;Computer Models;Computing Methodologies;Corpus striatum structure;Data;data quality;Databases;deep neural network;design;Development;Disease;Encapsulated;Evolution;experimental study;extrastriate;Eye;Face;Functional Magnetic Resonance Imaging;fusiform face area;Goals;Human;Image;Impairment;Individual;insight;interest;Location;Maps;Mentors;Methods;Modeling;Monkeys;Network-based;neural;neuroimaging;neuroprosthesis;Neurosciences;neurosurgery;object recognition;Pattern;Perception;Performance;Phase;Population;Positioning Attribute;public health relevance;Reading;Recovery;Research;Resolution;response;Rest;screening;Series;Social Functioning;Stimulus;Supervision;System;Testing;Text;theories;ultra high resolution;ventral visual stream;Vision;vision development;Visual;Visual Cortex;visual information;Visual Pathways;Visual Perception;visual processing;visual stimulus;Work

PROJECT_TITLE: Towards a computationally precise characterization of the human ventral visual pathway

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative We request support through this administrative supplement mechanism for an upgraded imaging system to replace our currently non-functional camera and outdated imaging software. We are currently using a loaner camera to maintain critical, but minimal, imaging capabilities. The research supported by this request is focused on understanding the mechanisms of formation of primordial germ cells during embryogenesis, a process essential for sexual reproduction in animals.

PI_NAMEs: WESSEL, GARY M (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Administrative Supplement;animal resource;Animals;Antisense Oligonucleotides;Biochemical;Biology;Biomedical Research;Cell Transplantation;Cells;Cellular biology;Characteristics;Chordata;Coupled;CRISPR/Cas technology;Development;Drops;Echinodermata;Embryo;Embryonic Development;Evaluation;Female;Genes;Genomics;Germ Lines;Image;imaging capabilities;imaging software;imaging system;Immune;in vivo;longitudinal analysis;male;Metabolic;Microinjections;Micromanipulation;Microscope;Molecular;Morphology;mRNA sequencing;Natural regeneration;optogenetics;Organism;Process;Reagent;Research;Research Support;RNA;Sea Urchins;serial imaging;Series;Sexual Reproduction;Sister;small molecule;Specific qualifier value;Starfish;Structure of primordial sex cell;System;Tissue Transplantation;Work

PROJECT_TITLE: Mechanisms of specification, quiescence, and regeneration of primordial germ cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: FREDERICK

ORG_NAME: LEIDOS BIOMEDICAL RESEARCH, INC.

PI_NAMEs: ROACH, JOHN  (contact)

PROJECT_TERMS: alpha helix;anti-cancer research;Antibodies;Antigens;Biological Products;cGMP production;Clinical;Cyclic GMP;DNA;DNA Vaccines;Engineering;gp160;HIV;HIV Envelope Protein gp120;HIV vaccine;Human;immunogenicity;Laboratories;manufacture;Memory;Molecular Conformation;monocyte;novel;Phase I Clinical Trials;Program Development;Proteins;response;Safety;Testing;vaccine candidate;vaccine platform;Vaccines

PROJECT_TITLE: CGMP MANUFACTURE OF TWO HIV DNA VACCINES AND ONE HIV PROTEIN VACCINE COMPONENT


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity

ORG_CITY: NEW YORK

ORG_DEPT: PHYSIOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: To understand the etiology of metabolic disorders and motivated behavior it is essential that we gain better insight into the neuronal mechanisms that regulate metabolism and behavior. We propose studies that will assess and define the role of lipid metabolism in the arcuate melanocortin neurons in the regulation of feeding behavior and energy metabolism. The proposed studies are a logical continuation of our ongoing studies and, if successful, their completion will unmask a novel mechanistic principle in central regulation of feeding and systemic metabolism.

PI_NAMEs: DIANO, SABRINA  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Acute;Affect;Anabolism;Appetite Stimulants;Behavior;Catabolic Process;Catabolism;Ceramides;Chimeric Proteins;Chronic;Data;Development;diet-induced obesity;Disinhibition;Down-Regulation;Eating;Elements;Endoplasmic Reticulum;Energy Metabolism;Enzymes;Etiology;Fasting;fatty acid metabolism;Fatty Acids;feeding;Feeding behaviors;Food deprivation (experimental);Generations;Genes;High Fat Diet;Hypothalamic structure;in vivo calcium imaging;insight;Link;lipid metabolism;Lipids;long chain fatty acid;Mediating;member;Messenger RNA;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolism;Mitochondria;motivated behavior;Neurons;novel;Obese Mice;oxidation;parabrachial nucleus;Pathway interactions;Phenotype;Physiological Processes;Play;Production;Protein Family;Proteins;Regulation;Role;RTN4 gene;Signal Transduction;Site;Sphingolipids;sphingosine 1-phosphate;Sphingosine-1-Phosphate Receptor;Structure of nucleus infundibularis hypothalami;Testing;Up-Regulation

PROJECT_TITLE: Hypothalamic lipid signaling in metabolism regulation

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research;Kidney Disease

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Chronic kidney disease continues to be a significant factor in global morbidity and mortality. Therapeutic options halting progression from acute kidney injury to chronic kidney disease still represent an unmet need. Here we will study the roles of complement component 5 receptor 1 activation in kidney tubular cells and myeloid cells after kidney injury.

PI_NAMEs: YU, MON-WEI  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: 3-Dimensional;Acceleration;Actins;Acute;Acute Renal Failure with Renal Papillary Necrosis;Adenosine Triphosphate;Adult;Affect;Animals;antagonist;Apoptosis;Area;Aristolochic Acids;Autoimmune Diseases;Awareness;Big Data;Biology;C5a anaphylatoxin receptor;career;career development;Cell Aging;Cell Cycle Arrest;cell injury;Cell Survival;Cells;Chronic Kidney Failure;Clinical;Complement;Complement 5a;Complement Activation;Complement component C5;Data;Data Analyses;design;Development;Disease Progression;End stage renal failure;Environment;Epithelial Cells;experience;experimental study;Faculty;Fibrosis;Foundations;Future;Genetic;Glycolysis;Grant;Hallmark Cell;Health;Histologic;Homeostasis;Hospitals;Human;Immune;Immunologics;Immunology;In Vitro;in vivo;Infection;Infiltration;Inflammasome;Inflammation;Inflammatory;Injury;Injury to Kidney;innovation;K-Series Research Career Programs;Kidney;Kidney Diseases;kidney fibrosis;Kidney Transplantation;Knowledge;Lead;Length of Stay;Macrophage;Manuscripts;Mediating;medical schools;Metabolic;mitochondrial dysfunction;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Myeloid Cell Activation;Myeloid Cells;Nephrology;novel;novel marker;Organoids;Outcome;Oxygen;Pathogenesis;Patients;Phagocytes;Phagocytosis;Phase;Population;Preparation;Prevalence;prevent;Production;profibrotic cytokine;Reactive Oxygen Species;receptor;Recovery;recruit;Role;Scientist;senescence associated secretory phenotype;Signal Transduction;single cell analysis;skills;Smooth Muscle;Solid;Techniques;Testing;Therapeutic;Tissues;tool;Training;Training Activity;Tubular formation

PROJECT_TITLE: Unanticipated roles of C5aR1 Signaling Leading from Acute to Chronic Kidney Disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Data Science;Mental Health;Networking and Information Technology R&D (NITRD)

ORG_CITY: RESTON

ORG_NAME: CARAHSOFT TECHNOLOGY CORPORATION

ORG_STATE: VA

PI_NAMEs: DRINKWINE, TERRY  (contact)

PROGRAM_OFFICER_NAME: WEBER, MICHAEL NICHOLAS N

PROJECT_TERMS: Acceleration;Address;Biomedical Research;Cloud Computing;Cloud Service;cloud storage;Communities;computerized tools;Data;Data Commons;data ecosystem;data repository;Data Science;Data Set;Economics;FAIR principles;Funding;Goals;Image;Individual;large datasets;Modeling;Modernization;Phase;Policies;Procedures;Process;programs;Research Infrastructure;Research Personnel;Science;Series;service providers;Services;Strategic Planning;Technology;Testing;United States National Institutes of Health;Work

PROJECT_TITLE: STRIDES


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Narrative This project is relevant to public health because it addresses a novel mechanism of mesenchymal lineage dysfunction and bone loss in aging. If successful, it will provide a scientific basis for development of new strategies to prevent and/or treat bone loss. It is also expected to advance the field of bone biology by elucidating yet unknown mechanisms connecting phagocytic activity of mesenchymal stromal cells, subsequent metabolic disruption, senescence and their dysfunction leading to decreased osteogenic capacity and bone loss. This is highly relevant to the NIH mission of developing fundamental knowledge that will help to reduce the burdens of human aging and disability.

PI_NAMEs: CALVI, LAURA M (contact);ELISEEV, ROMAN

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Acceleration;Address;Adult;age related;Aging;Apoptotic;BAI1 gene;Biology;bone;bone aging;bone loss;Bone Marrow;Bone marrow failure;Cell Aging;Cells;Chronic;Data;Degenerative Disorder;Development;disability;Disease;Dose;Functional disorder;Genetic Models;Genetic Transcription;Health;Human;In Vitro;in vivo;innovation;Knowledge;Maintenance;Mediating;Mesenchymal;mesenchymal stromal cell;Metabolic;Metals;Mission;Mitochondria;mitochondrial dysfunction;Mus;neutrophil;novel;old mice;osteoblast differentiation;osteogenic;osteoimmunology;overexpression;Oxidative Stress;particle;pathogen;Pathogenicity;Pathologic;Phagocytes;Phagocytosis;preclinical study;prevent;Process;Public Health;Role;senescence;serine receptor;skeletal;Skeleton;stem;Stromal Cells;Testing;Transgenic Organisms;United States National Institutes of Health

PROJECT_TITLE: Efferocytosis by Bone Marrow Stromal Cells and Bone Aging


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative This renewal would continue the tradition of innovative training for top-notch neuroscientists at Washington University. The proposed Neuroscience Pipeline will prepare underrepresented students for graduate-level studies through advanced educational and research experiences, intensive advising and dedicated community outreach. These efforts, combined with our mentor training and evaluation plans, should be scalable and findings translatable to those who share our goals of changing the local culture of mentoring future scientists and increasing diversity in the neurosciences.

PI_NAMEs: HERZOG, ERIK  (contact)

PROGRAM_OFFICER_NAME: JONES, MICHELLE

PROJECT_TITLE: BP-ENDURE: The St. Louis Neuroscience Pipeline


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Human Genome;Women's Health Research

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: NARRATIVE BRCA1-BARD1 and BRCA2 are involved in DNA double-strand break repair and replication fork preservation by homology-directed DNA repair (HDR). Our research project strives to elucidate the functions of these factors and their associated HDR partner proteins in the execution of key HDR stages. This is now possible because we have developed robust systems to obtain highly quality protein preparations for mechanistic workup. As such, we are well positioned to leverage our expertise in biochemistry, biophysics, structural biology, and cell biology to fill knowledge gaps regarding HDR mechanisms and regulation in human. The information that will emanate from our work has strong health relevance, as DNA repair deficiency is associated with aging, neurological disorders, infertility, and cancer.

PI_NAMEs: ZHAO, WEIXING WILSON (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Address;Affect;Affinity;Aging;ATP phosphohydrolase;Attenuated;Bacteria;BARD1 gene;Binding;Biochemical;Biochemistry;Biological Assay;Biophysics;brca gene;BRCA1 gene;BRCA2 gene;Breast;Catalysis;Cells;Cellular biology;Chemicals;Chromatids;Chromatin;Chromosomes;cofactor;Complex;DNA;DNA Binding;DNA Double Strand Break;DNA fiber assay;DNA Maintenance;DNA Mimicry;DNA Repair;DNA Repair Disorder;DNA Repair Gene;DNA replication fork;Double Strand Break Repair;ds-DNA;Eukaryota;Excision;Filament;Genetic Recombination;Genome;Health;Human;Impairment;Infertility;Invaded;Joints;Knowledge;Laboratories;Lesion;Licensing;Maintenance;Malignant Neoplasms;Mammals;Mammary Neoplasms;Mediating;Mediator;Modeling;Molecular;mutant;Nervous System Disorder;novel;Nucleoproteins;Nucleosomes;Organ;ovarian neoplasm;Ovary;PALB2 gene;Play;Positioning Attribute;Postdoctoral Fellow;Preparation;preservation;presynaptic;Process;protein complex;Proteins;Publishing;Rad51 recombinase;Radiation;Reaction;reconstitution;Regulation;Research Project Grants;Role;Saccharomyces cerevisiae;Saccharomycetales;Sequence Homologs;single molecule;Single-Stranded DNA;Source;SS DNA BP;Stress;structural biology;Structure;Synapses;synergism;System;Tail;Testing;Tumor Suppressor Proteins;tumorigenesis;Work

PROJECT_TITLE: Genome Maintenance via the BRCA-RAD54 Axis

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PI_NAMEs: SAMSONRAJ, REBEKAH MARGARET  (contact)

PROGRAM_OFFICER_NAME: ZHOU, YANG

PROJECT_TERMS: Allogenic;Biomechanics;Biophysics;bone;bone healing;bone repair;Calvaria;Cell Aging;cell preparation;Cell surface;Cell Therapy;Cells;Cephalic;Characteristics;cytokine;Defect;Gene Expression;genetic manipulation;Genomic approach;Growth Factor;Heterogeneity;improved;In Vitro;in vivo;innovation;mechanical signal;Mesenchymal Stem Cells;Modeling;Mus;Musculoskeletal Diseases;novel;osteoblast differentiation;Osteogenesis;osteogenic;Outcome;Phenotype;preconditioning;Proliferating;Regenerative Medicine;regenerative therapy;Research;Safety;senescence;senescent cell;senolytics;Signal Transduction;single cell genomics;single-cell RNA sequencing;stem cell population;stem cells;stemness;therapy outcome;tissue repair;Transplantation Conditioning;vibration

PROJECT_TITLE: Noninvasive preconditioning of mesenchymal stem cells to improve potency for bone repair


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hematology;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Social Determinants of Health;Telehealth

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Adolescent and young adult (AYA) cancer survivors, live with emotional distress and health care demands that exceed those of their peers, but can have difficulty accessing the care they need. In a 5-site national study, this research will adapt a tested, personalized, interactive digital and telehealth survivorship program to the needs of AYA survivors. We will test the AYA-focused survivorship intervention in a randomized controlled trial to see if it improves emotional distress and adherence to health care guidelines after 3 and 12 months when compared to AYA survivors who receive access to a website of annotated links to existing survivorship resources followed by delayed access to the digital survivorship program after 12 months.

PI_NAMEs: BAKER, KEVIN S (contact)

PROGRAM_OFFICER_NAME: ADAMS, LYNN S

PROJECT_TERMS: 2 arm randomized control trial;Acceleration;active control;Adherence;Adolescent and Young Adult;Adverse effects;adverse outcome;Age;arm;barrier to care;Cancer Center;Cancer Survivor;cardiometabolism;Caring;Clinic;Clinical;Colorectal Cancer;comparison control;coping;cost;Data;design;Devices;Diagnosis;digital;digital delivery;digital health;digital intervention;Dissemination and Implementation;Distress;Dose;efficacy evaluation;Elements;Eligibility Determination;emotional distress;Environmental Risk Factor;experience;Goals;Guidelines;Health;health literacy;Health Services Accessibility;Health Status;Healthcare;Hematopoietic Stem Cell Transplantation;high risk;Improve Access;improved;improved outcome;Informatics;informatics infrastructure;Internet;Intervention;intervention participants;intervention program;Knowledge;leukemia;Link;literacy;Lymphoma;Malignant Neoplasms;Manuals;meetings;Melanoma;Methodology;Methods;mobile application;Modality;Modeling;mortality;novel;Outcome;Participant;peer;Positioning Attribute;primary endpoint;primary outcome;programs;psychosocial;Public Health Informatics;Randomized;Randomized, Controlled Trials;Recommendation;Reporting;Research;Resources;response;Risk;risk stratification;Sarcoma;scale up;secondary outcome;Self Efficacy;Self Management;self-management program;Site;skills;social media;sociodemographic factors;sociodemographics;socioeconomics;Survivors;survivorship;System;Technology;telehealth;Testing;transplant survivor;Travel;treatment center;Treatment Efficacy;Visit;web site

PROJECT_TITLE: An INteractive Survivorship Program to Improve Healthcare REsources [INSPIRE] for Adolescent and Young Adult (AYA) Cancer Survivors


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PI_NAMEs: WARDELL, CHRISTOPHER  (contact)

PROJECT_TITLE: Quantitative Imaging Analysis and Genomics of Multiple Myeloma


NIH_SPENDING_CATS: Aging;Neurosciences

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Microglia are non-neuronal cells in the CNS that can potently affect the function and integrity of neuronal synapses. Here, we will use novel approaches to study whether intracellular organelles called lysosomes can simultaneously regulate multiple microglial attributes that impact synapses, revealing new strategies for targeting these cells to preserve synaptic function throughout the lifespan. This work will determine how regional differences in microglial lysosome function during aging may contribute to regional differences in synapse loss and dysfunction, which are tied to age-related decline in movement and cognition and may increase risk of neurodegenerative disease.

PI_NAMEs: DE BIASE, LINDSAY MITCHELL (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Affect;age related;age related changes;age related decline;Aging;aging related;Autophagocytosis;Basal Ganglia;Behavior;Brain region;Calcium;Cell Nucleus;Cell Physiology;Cell Shape;Cells;Chemosensitization;CLN3 gene;Code;Cognition;cognitive function;confocal imaging;Data;Degenerative Disorder;density;Depressed mood;dopaminergic neuron;Electrophysiology (science);Excitatory Synapse;Exhibits;experimental study;Face;follow-up;functional decline;Functional disorder;functional status;Gene Expression;Genes;Goals;Health;Homeostasis;Image;Impaired cognition;Impairment;in vivo;Inflammation;Inflammatory;interdisciplinary approach;Knockout Mice;life span;Link;Lipids;Lipofuscin;Location;lysosome membrane;Lysosomes;Macrophage;Maps;Measures;Membrane;Methods;Microglia;middle age;Molecular;Molecular Target;Motility;Movement;Mus;Neurodegenerative Disorders;Neuroglia;Neurons;neuroprotection;Neurosciences;novel;novel strategies;Nucleus Accumbens;Organelles;overexpression;Parkinsonian Disorders;pars compacta;Pathway interactions;Peptide Hydrolases;Phagocytes;Phagocytosis;Phenotype;Play;Population;Positioning Attribute;preservation;Process;Production;Proliferating;Property;Proteins;Proton Pump;receptor;Recycling;regional difference;Regulation;response;Risk;Role;Shapes;Signal Transduction;single-cell RNA sequencing;Slice;Substantia nigra structure;Symptoms;Synapses;synaptic function;Synaptic plasticity;synaptogenesis;Testing;tissue fixing;transcriptome sequencing;Variant;Ventral Tegmental Area;virtual;Vulnerable Populations;Work;young adult

PROJECT_TITLE: Microglial lysosomes and selective neuronal vulnerability

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Complementary and Integrative Health;Natural Products

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: PROJECT NARRATIVE Genome mining of natural products from sequenced microbial genomes is a promising strategy to new human therapeutics. To increase our abilities in performing genome mining, this MIRA proposal will i) fundamentally understand the enzymology of biosynthetic enzymes that make natural products; and ii) develop more effective methods of mining with a particular emphasis on using resistance enzymes to prioritize biosynthetic pathways that may produce natural products of desired biological activities.

PI_NAMEs: TANG, YI  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Anabolism;Area;bioactive natural products;Biological;Chemical Structure;Cyclization;Educational process of instructing;Enzymatic Biochemistry;enzyme activity;Enzymes;Family;Fungal natural products;Gene Cluster;Genome;Grant;Human;Investigation;Knowledge;Link;Metabolism;Methods;microbial genome;Microbial Genome Sequencing;Mining;Molds;Natural product discovery;Natural Products;Natural Resistance;Nature;Organism;Pathway interactions;programs;protein transport;Proteins;Renaissance;Research;Research Activity;Resistance;Resistance development;resistance gene;resistance mechanism;Structure;synthetic biology;Therapeutic;tool;Variant

PROJECT_TITLE: MIRA: Enzymology and Self-Resistance of Natural Product Biosynthesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(07)R]


ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Project Narrative An historic shift has occurred in the approach to infant feeding among mothers and other parents with HIV (MoPWH) in the United States (US). US guidelines have been updated to support shared decision-making regarding infant feeding choices in MoPWH on treatment with sustained viral suppression. The UPLIFT study will address knowledge gaps regarding infant feeding preferences, practices, and outcomes among MoPWH and providers in the US. Study findings will inform best practices for infant feeding counseling and the care of MoPWH who chose to breastfeed in the US.

PI_NAMEs: ABUOGI, LISA LYNN (contact)

PROJECT_TITLE: PS24-040 UPLIFT Study (Understanding Parental Lactation and Infant Feeding decisions Tailored to people with HIV.\")

STUDY_SECTION_NAME: Special Emphasis Panel[ZPS1 SPE (61)]


ORG_CITY: CHANTILLY

ORG_NAME: FOUR POINTS TECHNOLOGY, LLC

PI_NAMEs: LIPKIN, JOEL A (contact)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_DEPT: ANESTHESIOLOGY

PHR: A deficit in cerebral blood flow hemodynamics is an early feature of cerebral small vessel disease — a leading cause disease pathogenesis. Here we describe how capillary of cognitive decline and dementia — which fundamental alterations in extracellular matrix proteins disrupt endothelial cell metabolism in both Alzheimer's and suggests that cerebrovascular dysfunction has a key role in small vessel diseases. Impaired mitochondrial function then prevents the microcirculation to increase cerebral blood flow in response to neuronal activity, thereby contributing to disease progression.

PI_NAMEs: DABERTRAND, FABRICE  (contact);GARCIA, ANASTACIA M

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: 3-Dimensional;abeta oligomer;Action Potentials;Address;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Amyloid;Amyloid beta-Protein;Animals;Arterial Disorder;arteriole;autocrine;Automobile Driving;Autopsy;autosome;Bioenergetics;Blood;Blood capillaries;Blood flow;Blood Vessels;Brain;Brain imaging;brain tissue;Capillary Endothelial Cell;Cell Energetics;Cell Separation;Cells;Cellular Metabolic Process;Cerebral Amyloid Angiopathy;cerebral capillary;cerebral microvasculature;Cerebral small vessel disease;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;Cerebrovascular system;Cerebrum;Characteristics;Clinical;cofactor;course development;Data;Defect;Dementia;Deterioration;Development;Dimensions;Disease;Disease Progression;Electronics;Elements;Endothelial Cells;Endothelium;Epidermal Growth Factor Receptor;extracellular;Extracellular Matrix;Extracellular Matrix Proteins;Fatigue;feeding;Foundations;Goals;hemodynamics;Human;human model;Hyperemia;Image;Impaired cognition;Impairment;inward rectifier potassium channel;Kir2.1 channel;Link;Mediator;Memory Loss;Metabolic;Metabolism;Microcirculation;Microscopy;Microvascular Dysfunction;Mitochondria;mitochondrial dysfunction;mixed dementia;Modeling;Molecular;mouse model;multidisciplinary;multiple omics;Mus;Muscle Cells;mutant;Mutation;neural;Neurons;neurovascular;neurovascular coupling;NOTCH3 gene;novel;Organ;parenchymal arterioles;Pathogenesis;Pathologic;Pathologic Processes;Pathway interactions;Patients;Pericytes;pharmacologic;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylinositols;Phospholipids;Phosphorylation;Play;Preparation;prevent;Process;Production;receptor;Receptor Inhibition;Research;response;Role;sensor;Signal Transduction;skills;Structure;Subcortical Infarctions;Subcortical Leukoencephalopathy;Symptoms;Testing;Therapeutic;Time;Tissues;transcriptomics;Transgenic Mice;Transgenic Organisms;vascular cognitive impairment and dementia;Vasodilation;Vasodilator Agents;Work

PROJECT_TITLE: Brain capillary endothelial cell energetics and neurovascular uncoupling in dementia

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-M (21)]


ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: NARRATIVE Type 1 diabetes (T1D) is a chronic illness resulting from loss of insulin producing beta cells leading to high blood glucose levels. Restoring autonomous glucose control in T1D requires beta cell replacement therapy, which is dependent on strategies to regenerate endogenous beta cells and expand islets ex vivo for transplant. This proposal will define new signaling mechanisms governing beta cell proliferation that may exert therapeutic benefits for people with T1D.

PI_NAMEs: COX, RICHARD A (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: 2 year old;Acute;Address;Age;aged;Aging;Automobile Driving;Award;Beta Cell;beta cell replacement;betacell therapy;Binding Proteins;Binding Sites;Biogenesis;Biological Assay;Blood Glucose;blood glucose regulation;career;cdc Genes;Cell Cycle Regulation;Cell Physiology;Cell Proliferation;cell replacement therapy;cell type;Cellular Metabolic Process;Chronic Disease;Complex;Continuous Glucose Monitor;Couples;Data;Development;Diabetes Mellitus;DNA Binding;experimental study;fatty acid metabolism;feeding;GA-binding protein transcription factor;Genes;Genetic;genome-wide;Glucose;Glycolysis;Goals;High Fat Diet;Human;Hyperglycemia;in vivo;Insulin;Insulin deficiency;Insulin-Dependent Diabetes Mellitus;Intervention;islet;Knockout Mice;Knowledge;Leptin;leptin receptor;Link;Metabolic;Metabolism;metabolomics;Mitochondria;Modeling;Molecular;Mus;Natural regeneration;novel;novel strategies;novel therapeutics;Nutrient;old mice;Oxidative Phosphorylation;Patients;Persons;Physiological;Proliferating;protein complex;Proteins;regenerative;Research Personnel;Respiration;response;Role;Signal Transduction;single-cell RNA sequencing;Sorting;Stimulation of Cell Proliferation;Stimulus;Supporting Cell;Testing;Therapeutic;tool;transcription factor;Transplantation

PROJECT_TITLE: GABP is a novel regulator of beta cell metabolism and proliferation


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Precision Medicine

ORG_CITY: LA JOLLA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Late talking in toddlers is a common reason for pediatrician concern because it can be a precursor of either persistent language disorder; worsening functional ability such as autism or global delay; or, oddly enough, the opposite: a neurotypical outcome, and yet, predictors of such dramatically divergent outcomes remain elusive. In a large representative sample of late talkers, we will identify toddler period precursors and predictors of five different preschool language and clinical outcomes by leveraging our cohort of N=1,667 late talkers and contrast typical and autism toddlers all uniformly ascertained, recruited, deep phenotyped, and demographically characterized. In an eye tracking (ET) and precision medicine-based approach, we will use normative data from our innovative social auditory and social visual attention ET paradigms to identify multimodality late talker social ET-clinical subtypes and novel subtype predictors of pre-school outcomes.

PI_NAMEs: COURCHESNE, ERIC ;PIERCE, KAREN L (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Accounting;Activities of Daily Living;Address;Age;Age Months;Analysis of Variance;Attention;Auditory;autism spectrum disorder;Characteristics;Classification;Clinical;Clinical Data;clinical phenotype;clinical subtypes;cohort;Data;Data Set;Development;Diagnosis;diagnostic biomarker;Entropy;Evaluation;Eye;Face;gaze;global developmental delay;Growth;Image;Individual Differences;innovation;Intake;Language;Language Delays;Language Development;Language Disorders;language outcome;Language Tests;Length;Licensing;Linear Regressions;Link;Logistic Regressions;longitudinal analysis;Measures;Meta-Analysis;Modeling;multimodality;Nature;neurobehavioral;novel;Nursery Schools;Oral cavity;Outcome;outcome prediction;pediatrician;Phenotype;Play;precision medicine;predict clinical outcome;Procedures;Psychologist;recruit;Reference Standards;Reporting;response;Review Literature;ROC Curve;sample fixation;Sampling;School-Age Population;sex;Shapes;social;social attention;Social Development;Socialization;sound;Source;Specificity;Speech;Standardization;standardize measure;statistics;Technology;Testing;Time;Toddler;tool;trait;Validation;verbal;Videotape;Visual;Visual attention;visual tracking;Vocabulary

PROJECT_TITLE: Leveraging a Unique Dataset to Identify Outcome Predictors in Late Talkers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-R (51)]


ORG_CITY: PITTSBURGH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: cAMP, synthesized by adenylyl cyclase, is present in all cell types and is used by several hormones for their normal function. We have recently identified a role for CAP1-Rap1 complex as a new regulatory unit in this pathway and a combination of in vitro biochemistry and optogenetics approaches in cells are proposed to study the molecular organization of the cyclase-CAP1-Rap1 complex and its function in regulating cAMP dynamics. Their characterization should aid our deeper understanding of the GPCRs’ spatiotemporal organization and function and might provide novel avenues for therapeutic intervention.

PI_NAMEs: ALTSCHULER, DANIEL L (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Address;Adenylate Cyclase;Affect;Binding;Biochemistry;Biological;Cell membrane;cell type;Cells;Chemosensitization;Chronic;chronic pain;Code;Complex;Cyclic AMP;Event;Family;FDA approved;Feedback;G-Protein-Coupled Receptors;Generations;Genetic Transcription;GTP-Binding Protein alpha Subunits, Gs;Hormones;In Vitro;Inflammation;insight;interdisciplinary approach;interest;Intervention;Laboratories;Membrane;Migraine;Molecular;nanobodies;novel;Nuclear;optogenetics;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phase;Physiological;Protein Isoforms;receptor;Regulation;response;Role;Second Messenger Systems;sensor;Signal Transduction;spatiotemporal;Specificity;Testing;Therapeutic Intervention

PROJECT_TITLE: Novel mechanisms in the control of cAMP dynamics


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Neurosciences;Nutrition;Pediatric;Prevention

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE  As more adolescents with type 1 diabetes (T1D) opt to follow very low carbohydrate diets to improve glucose control, it is becoming increasingly important to study the metabolic and neurological changes that occur on these diets and how these effect patient safety. Understanding the impact of dietary changes on metabolic and neurological factors will help guide clinical advice about the overall safety and efficacy of these diets in the pediatric T1D population. This work will be the basis of future studies testing dietary interventions to improve glycemic control and ensure that these dietary interventions are safe for growing youth with T1D.

PI_NAMEs: NALLY, LAURA MARIE (contact)

PROGRAM_OFFICER_NAME: THORNTON, PAMELA L

PROJECT_TERMS: Adipose tissue;Adolescent;Adult;Affect;age group;American;Awareness;behavior change;Biometry;Blood;Blood Glucose;blood glucose regulation;Brain;Brain Injuries;Calories;Carbohydrates;Cessation of life;Child;Childhood;Circulation;Clinical;Closure by clamp;Complications of Diabetes Mellitus;Continuous Glucose Monitor;Cross-Over Studies;Data;diabetes control;Diabetes Mellitus;Diabetic Ketoacidosis;Diet;dietary;Dietary Intervention;Dose;efficacy testing;Ensure;environmental change;Epinephrine;euglycemia;experience;Faculty;follow-up;Functional Magnetic Resonance Imaging;Future;Glucagon;Glucose;glucose metabolism;glucose production;glucose sensor;glycemic control;Glycerol;Glycogen;Goals;Hepatic;high risk;Hormones;Human;Hydrocortisone;Hyperglycemia;Hyperinsulinism;Hypoglycemia;hypoglycemia unawareness;Impairment;improved;Individual;Infusion procedures;Insulin;Insulin-Dependent Diabetes Mellitus;Intake;interest;Isotopes;Ketones;Ketosis;Kidney Diseases;Knowledge;Leadership;lipid metabolism;Lipolysis;Liver;Measures;Mentors;Metabolic;metabolic abnormality assessment;Metabolism;Methods;Nervous System Trauma;Neurocognitive Deficit;Neurologic;Neurologic Symptoms;Neuropathy;Nonesterified Fatty Acids;Norepinephrine;Nutritional;Parents;Participant;patient safety;Physicians;Physiological;Population;Postprandial Period;prevent;Production;Questionnaires;Randomized;Recommendation;Reporting;Research;Research Design;Research Personnel;response;restoration;Retinal Diseases;Risk;Safety;Scientist;Seizures;skills;stable isotope;Symptoms;Techniques;Testing;Time;Tracer;Translating;United States;Work;Youth

PROJECT_TITLE: Metabolic and Neurological Changes Induced by a Very Low Carbohydrate Diet in Youth with Type 1 Diabetes

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project narrative (From R35) Humans have many unique features that distinguish them from other animals, ranging from behavior and social organization to susceptibility to infectious and chronic diseases. Elucidating the origin of these novelties is essential for understanding the genetic basis of human biology, individual variation, and health risk factors. The goal of this project is to reconstruct the molecular mechanisms of evolutionary innovations at all levels of biological organization, from new functional elements in the genome to new genetic pathways to new anatomical structures, using experimentally tractable animal models.

PI_NAMEs: KOPP, ARTYOM  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;Anatomy;Animal Model;Animals;Behavior;Biological;Biological Models;Cell Differentiation process;cell type;Cells;Chronic Disease;Collection;Communicable Diseases;Complex;Development;DNA Sequence;Drosophila genus;Elements;Event;Evolution;external genitalia;Female;Gene Expression;Gene Expression Regulation;gene function;Genes;Genetic;Genome;genome editing;Goals;Health;Human;Human Biology;individual variation;innovation;Insecta;Knowledge;Life;Maintenance;male;Male Genital Organs;Modeling;Modification;Molecular;Molecular Genetics;Morphology;mutant;Mutation;novel;Nutrient;Organ;parent project;Pathway interactions;Pattern;Planet Earth;Population;Predisposition;Process;recruit;Regulatory Element;Regulatory Pathway;reproductive;Research;Risk Factors;Role;Series;sex;sex determination;sex linked trait;sexual dimorphism;Shapes;single cell sequencing;single molecule;social organization;Source;Structure;Testing;Tissue Model;Tissues;trait;transcription factor;Transgenic Organisms;Translating;Variant;Work

PROJECT_TITLE: Molecular Genetics of Evolutionary Innovations


NIH_SPENDING_CATS: Aging;Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Rare Diseases;Rehabilitation

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Narrative The scientific goal of this supplement is to develop a cutting-edge paradigm using emotional reactivity to movie clips as a lens for assessing language capacity in aphasia. More accurate measurement of language abilities in individuals with stroke-induced aphasia will facilitate the optimization of fMRI language mapping in other populations proposed in the parent grant (aphasia induced by brain tumor), and other populations in general (e.g., aphasia induced by epilepsy). Critically, if our proposed approach using implicit emotional reactivity and eye behavior as proxies for language comprehension gains empirical support, it will catalyze a substantive reevaluation in how language and cognition are assessed in persons with aphasia.

PI_NAMEs: LIEBENTHAL, EINAT ;TIE, YANMEI  (contact)

PROJECT_TERMS: Aphasia;Behavior;Behavioral;Behavioral Research;bilingualism;Boston;Brain;Brain Neoplasms;career;Certification;Clinical;Clip;Cognition;Communication impairment;Cultural Backgrounds;Data Analyses;Data Collection;Development;Doctor of Philosophy;Emotional;Epilepsy;Evaluation;Eye;Fellowship;Foundations;Functional Magnetic Resonance Imaging;gaze;Goals;graduate student;Grant;Hearing;Hispanic ancestry;Individual;innovation;Intervention;Language;language comprehension;lens;Lesion;Maps;Martens;Measurement;Measures;Methodology;Methods;movie;neuroimaging;Neuropsychology;parent grant;Participant;Pathologist;Performance;Persons;Physiological;Population;Postdoctoral Fellow;programs;Proxy;Research;Research Activity;Research Methodology;Research Personnel;Risk;Science;Speech;stroke-induced aphasia;Testing;timeline;Training;United States National Institutes of Health;Universities;visual tracking

PROJECT_TITLE: Research Supplement: Naturalistic Neuroimaging for Presurgical Language Mapping


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Obstacles on messenger RNAs cause ribosomes to collide with each other, resulting in a collision complexes of two ribosomes (disome) that are recognized and regulated by disome surveillance pathways. Perturbations of these surveillance systems result in neurodevelopmental and neurodegenerative diseases, but the mechanisms are poorly understood. At the completion of the proposed project, I aim to understand how disome homeostasis is regulated and how its dysregulation leads to neuronal diseases.

PI_NAMEs: MEYDAN MARKS, FATMA SEZEN  (contact)

PROJECT_TERMS: Affect;Binding;biological adaptation to stress;Biological Assay;Biological Models;Cell Death;Cells;Cellular Stress;Charcot-Marie-Tooth Disease;Complex;Computer Analysis;Coupled;Data;design;detection platform;Development;Disease;disease phenotype;Electrophysiology (science);Etiology;experimental study;Fluorescence;Fluorescence Microscopy;Foundations;Fragile X Syndrome;Future;Genes;Genetic Diseases;genome-wide;Goals;Health;Homeostasis;Human;Immunoprecipitation;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;inhibitor;inhibitor therapy;insight;Kinetics;large scale data;Link;link protein;Measures;Messenger RNA;Methods;Microscopy;Mutation;Neurodegenerative Disorders;neurodevelopment;Neurodevelopmental Disorder;Neuronal Differentiation;Neurons;new therapeutic target;overexpression;Pathology;Pathway interactions;Phenotype;Process;Proteins;Quality Control;Regulation;Reporter;Repression;Research;Research Personnel;response;Ribosomes;Role;sensor;Signal Pathway;single molecule;Stress;Study models;System;Techniques;Testing;Therapeutic;tool;Training;Transcript;transcriptome;transcriptome sequencing;Translating;translational impact;Translational Regulation;Translations;Work;Yeasts

PROJECT_TITLE: Regulation of ribosome collisions during health, development and disease


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Caregiving Research;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative The purpose of this research is to partner with Black caregivers of toddlers identified as late talkers to determine if their cultural communication practices are accurately captured by traditional language assessment practices. The long-term goal of this project is to develop culturally appropriate criteria for identifying Black children who are late talkers in order to reduce misidentification within marginalized communities.

PI_NAMEs: PRIVETTE, CHELSEA  (contact)

PROJECT_TITLE: Characterizing Late Talker Communication with Black Caregivers


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE A trained and diverse biomedical workforce requires support of educational programs at all levels, including those designed to provide students exposure to biomedical research, reinforce their intent to graduate with a science degree, and to prepare them for graduate studies leading to a career in research. The proposed summer research program will provide opportunities for students to improve their research skills and gain confidence in the research environment.

PI_NAMEs: BURGESS, ROBERT W. (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: addiction;Alzheimer's Disease;Bioinformatics;Biomedical Research;career;cohort;Communication;Databases;Dedications;design;Development;E-learning;Education;education research;Educational Curriculum;Educational workshop;Environment;Ethics;Evaluation;experience;Exposure to;Foundations;Funding;genetic resource;Genomics;Glaucoma;Grant;High School Student;Human Biology;human disease;improved;Institution;instrumentation;International;Internships;Laboratories;Laboratory mice;Lead;Learning;Learning Module;meetings;member;Mentors;Methods;Modernization;motor neuron degeneration;Neurobiology;outreach;Participant;Peripheral Nervous System Diseases;Personal Growth;Privatization;Procedures;Process;programs;recruit;Research;Resources;Retinal Diseases;Rett Syndrome;Science;Scientific Inquiry;Sensory Disorders;skills;Student recruitment;Students;summer research;summer student;symposium;Synapses;Talents;The Jackson Laboratory;tool;Training;Travel;undergraduate student;Underrepresented Students;Wages

PROJECT_TITLE: Summer Research Experience in Neurobiology at The Jackson Laboratory


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: DURHAM

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Late language emergence (late talking), affects one in five children. Late talking research has mostly relied on data from relatively small studies, and included participants who may not be representative of broader pediatric populations growing up in America today. This study will use real world data from electronic health records (EHR) to improve our understanding of late talking developmental trajectories thereby informing clinical decision-making and referral practices for late talking children.

PI_NAMEs: FRANZ, LAUREN ;GOLDSTEIN, BENJAMIN ALAN (contact)

PROJECT_TERMS: Address;Affect;Age Months;biomarker identification;Child;Child Development;Child Language;Childhood;Clinical;clinical decision-making;Code;cohort;Cohort Studies;cost;Data;Data Scientist;data sharing networks;Databases;Development;Diagnosis;Diagnostic;Disparity;Distant;Documentation;Early Intervention;electronic health data;Electronic Health Record;Environment;Equity;Ethnic Origin;experience;Face;follow-up;Genetic;Goals;health record;Home;improved;insight;Institution;Insurance Coverage;International Classification of Disease Codes;Intervention;Intervention Studies;Language;Language Development;Language Disorders;Machine Learning;Maps;Medical;Medical Records;Mental Health;minority communities;Natural Language Processing;Nature;Neurologic;novel;Outcome;Parents;Participant;Pathway interactions;pediatrician;personalized intervention;Phenotype;Population;Positioning Attribute;Psychiatrist;Race;Records;recruit;Research;response;Sample Size;service intervention;Services;sex;Site;Socioeconomic Status;Speech Disorders;Syndrome;Time;underserved community;United States;United States National Institutes of Health;Well Child Visits;Work

PROJECT_TITLE: Advancing Identification of Late-Talking Children and Mapping their Developmental Trajectories Using Real World Data from Electronic Health Records


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Hispanic adolescents are disproportionately burdened by type 2 diabetes and social determinants of health that negatively impact health behaviors and contribute to the development of this costly disease. This study will adapt a 12-week, evidence-based, culturally-grounded diabetes prevention program for delivery via telehealth and will test the feasibility, acceptability, and preliminary efficacy of the telehealth intervention. This study will provide novel information on the use of telehealth to reach and engage high-risk youth from vulnerable, health disparate communities in disease prevention efforts.

PI_NAMEs: SOLTERO, ERICA  (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: Accelerometer;acceptability and feasibility;Address;Adolescent;Adult;Age;Area;Award;behavior change;Body mass index;Body Weight decreased;Cellular Phone;Child Care;Childhood;Collaborations;Communication;community clinic;community engaged approach;Cost of Illness;COVID-19;Data Collection;design;Development;Devices;Diabetes Mellitus;Diabetes prevention;diabetes prevention program;diabetes risk;digital;Disease;Disease Outcome;disorder prevention;Disparity;Education;Educational workshop;Effectiveness;Ensure;evidence base;Exhibits;experience;Family;fasting glucose;feasibility testing;Feedback;field study;fitbit;Focus Groups;Foundations;Funding;Glycosylated hemoglobin A;Goals;Health behavior;Health behavior and outcomes;health care delivery;health disparity populations;Health education;Healthcare;high risk;Hispanic;Home;improved;innovative technologies;Insulin;Insulin Resistance;insulin sensitivity;Insurance Coverage;Internet;Intervention;intervention delivery;Interview;K-Series Research Career Programs;Life Expectancy;lifestyle intervention;lifetime risk;meetings;Mentors;Mentorship;Methods;Minority;minority children;multidisciplinary;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;nutrition;nutrition education;Obesity;Outcome;Parents;Participant;Persons;Phase;Physical activity;Population;Prediabetes syndrome;prevent;Prevention;Prevention program;Prevention strategy;preventive intervention;Process;programs;Quality of life;Randomized;recruit;remote delivery;Reporting;Research;Research Personnel;Sampling;Schedule;Science;Scientist;Self Determination;Self Perception;Services;skills;social determinants;social health determinants;Surveys;Technology;technology development;technology intervention;Telecommunications;telehealth;telehealthcare;Testing;Text Messaging;theories;tool;Training;Transportation;treatment as usual;Treatment Efficacy;United States Centers for Medicare and Medicaid Services;usability;usual care arm;vulnerable community;Work;Youth

PROJECT_TITLE: ADAPTING AND ASSESSING THE FEASIBILITY OF A TELEHEALTH DIABETES PREVENTIONPROGRAM FOR HISPANIC ADOLESCENTS

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK(M1)-1-B]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE People and animals learn associations between sensory cues and motor actions through trial and error to survive in a changing environment, yet, in some cases, people act on harmful learned associations, for example, in addiction, PTSD, OCD, autism and anxiety. We know that such cue-action learning requires a “rewiring” of brain circuits, i.e., synaptic plasticity between the neurons representing the sensory cue and the neurons representing the motor action, but we still do not know where in the brain this associative synaptic plasticity occurs. Here I propose to apply an innovative behavioral paradigm and optogenetic tools to dissect a candidate pathway underlying the learned association between a cue that is the activation of visual cortex and a forelimb motor action.

PI_NAMEs: REINHOLD, KIMBERLY  (contact)

PROGRAM_OFFICER_NAME: CHURCHILL, JAMES D

PROJECT_TERMS: addiction;Animals;Anxiety;Area;autism spectrum disorder;Behavior;Behavioral Paradigm;Brain;BRAIN initiative;cognitive function;cognitive process;Cues;Detection;Electrophysiology (science);Environment;experience;experimental study;Feedback;Food;Forelimb;Goals;in vivo;in vivo two-photon imaging;innovation;Learning;Link;Memory;Motor;motor behavior;motor control;Mus;neural;Neurons;optogenetics;Output;Pathway interactions;Pattern;Persons;Phase;Population;Post-Traumatic Stress Disorders;Postdoctoral Fellow;Process;Psychological reinforcement;recruit;Sensory;Short-Term Memory;superior colliculus Corpora quadrigemina;Synapses;Synaptic plasticity;System;Techniques;tool;Visual Cortex;Visual Pathways;Work

PROJECT_TITLE: Distributed Neural Activity Patterns Underlying Practice-Based Learning


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Genetics;Liver Disease;Organ Transplantation;Transplantation

ORG_CITY: PHILADELPHIA

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Many patients awaiting transplant die due to an inadequate supply or organs. One possible solution is the use of organs from animals, specifically pigs, but this is impeded by a robust xeno-immune response, physiologic incompatibilities and fear of xeno-zoonosis. We proposed to test novel gene editing techniques to address these barriers using a translational xeno-liver transplant model.

PI_NAMEs: MARKMANN, JAMES FRANCIS (contact)

PROGRAM_OFFICER_NAME: NABAVI, NASRIN N

PROJECT_TERMS: adaptive immune response;Address;Adhesions;Allografting;allotransplant;Animal Organ;Antibodies;attenuation;Binding;Blood;Blood Coagulation Disorders;Blood Coagulation Factor;Blood Platelets;Candidate Disease Gene;Cardiac;Cellular Immunity;Clinical;clinical application;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Coagulation Process;Complement;Consumption;CRISPR/Cas technology;Cryopreservation;Data;design;Endogenous Retroviruses;Engineering;Evaluation;ex vivo perfusion;experience;Family suidae;Fright;Functional disorder;gene editing technology;gene-editing approach;Genes;Genetic;Genetic Engineering;genetic payload;Goals;graft dysfunction;Heart;heart xenograft;Human;Immune response;Immunologics;Immunosuppression;improved;improved outcome;in vitro Assay;in vivo;industry partner;Infection;Inflammation;Infusion procedures;Injury;Innate Immune Response;Investigation;Ischemia;Kidney;Knock-in;Knock-out;Life;Liver;liver transplantation;liver xenograft;Modeling;Modification;novel;Organ;Organ Donor;Outcome;Papio;Pathway interactions;Patients;Perfusion;Physiological;pig genome;porcine model;prevent;Primates;Production;Protein Engineering;Proteins;Recovery;Regimen;Reperfusion Injury;Reperfusion Therapy;Reporting;Resources;Risk;Site;Source;Specificity;success;synergism;System;Techniques;Technology;Testing;Time;Tissues;tool;transmission process;transplant model;Transplantation;transplantation therapy;Treatment Protocols;vascular bed;Vertebral column;Work;Xenograft procedure;Zoonoses

PROJECT_TITLE: Liver Xenotransplantation using CRISPR-modified Porcine Organs

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: Project Narrative This project will generate fundamental knowledge of the molecular mechanisms underlying the protein-protein interactions of the APP ectodomain and the cellular consequences of these interactions. These studies have the potential to lay the foundation for future work to harness the fundamental functions of APP to counteract pathogenic pathways in Alzheimer's disease, Fragile-X Syndrome, and Autism Spectrum Disorders.

PI_NAMEs: RICE, HEATHER C. (contact)

PROJECT_TERMS: Address;Alzheimer's Disease;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Area;autism spectrum disorder;Biophysics;Career Choice;Cell Physiology;cell type;Cells;cognitive function;design;Developmental Process;Disease;Extracellular Domain;Family member;Foundations;Fragile X Syndrome;Future;gamma-Aminobutyric Acid;Health;Imaging Techniques;in vivo;interest;intravital imaging;Knowledge;Ligands;Mediating;Mitochondria;Molecular;Neurons;novel;parent grant;Pathogenicity;Pathway interactions;Phosphoglycerate Mutase;Physiological;protein protein interaction;Protein Serine/Threonine Phosphatase;receptor;Receptor Signaling;Regulation;Research;response;Signal Pathway;Work

PROJECT_TITLE: Research Supplements to Promote Diversity in Health-Related Research Mechanisms of APP ectodomain function


ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

PI_NAMEs: AKINS, DARRIN R. (contact)

PROGRAM_OFFICER_NAME: ARORA, KRISHAN

PROJECT_TERMS: Administrative Supplement;Advisory Committees;American Association for the Advancement of Science;Area;Award;career;career development;Chairperson;Communication;Development;Educational workshop;Evaluation;Faculty;Goals;Grant;Health Professional;improved;Individual;Institution;International;lectures;meetings;National Institute of General Medical Sciences;Oklahoma;operation;Outcome;Policies;Principal Investigator;programs;Research;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Resource Allocation;Resources;Role;Scientist;Students;symposium;Teacher Professional Development;Time;Travel;undergraduate research experience;United States National Institutes of Health;Vocational Guidance;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Health Services;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric Cardiomyopathy;Prevention;Rare Diseases

PHR: PROJECT NARRATIVE The scope of screening programs for hypertrophic cardiomyopathy, an often underrecognized cardiac condition associated with significant morbidity and mortality, is limited by the reliance on comprehensive imaging and genetic tests that are costly, time-consuming, and not widely available. The current project proposes a point-of- care strategy for the efficient screening of hypertrophic cardiomyopathy using a combination of electrocardiographic and echocardiographic algorithms specifically adapted for use with wearable devices and portable ultrasound technologies. The proposal will develop and test a multimodal, point-of-care strategy that will empower non-specialist providers to screen for this underdiagnosed condition, with the hope of improving early detection and timely referral to specialized centers.

PI_NAMEs: OIKONOMOU, EVANGELOS  (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Address;advanced analytics;Affect;Algorithms;Amyloid;Anatomy;Artificial Intelligence;autoencoder;Awareness;biobank;Board Certification;Cardiac;cardiac magnetic resonance imaging;Cardiovascular system;career;Case/Control Studies;Clinical;clinical heterogeneity;Clinical Informatics;Communities;Computer Models;computer science;Computer Vision Systems;Computing Methodologies;computing resources;Consumption;cost;Data;Data Set;deep learning model;denoising;design;Detection;Development;Devices;Diagnosis;diagnostic algorithm;Diagnostic tests;Disease;Early Diagnosis;Echocardiography;Electrocardiogram;Electronic Health Record;Eligibility Determination;Emergency department visit;empowerment;Ensure;Event;experience;feasibility testing;Fellowship;General Population;Generations;genetic testing;Goals;Health;Health system;heart dimension/size;hypertensive heart disease;Hypertrophic Cardiomyopathy;Image;implementation science;improved;improved outcome;Individual;inherited cardiomyopathy;Label;Lead;Learning;Left Ventricular Hypertrophy;Libraries;Machine Learning;machine learning algorithm;Magnetic Resonance;Magnetic Resonance Imaging;Maps;Medical Informatics;medical schools;Mentors;Mentorship;Methods;Modality;Modeling;Morbidity - disease rate;Morphologic artifacts;mortality;multimodal learning;multimodality;Noise;novel;novel therapeutics;Outcome;Pathway interactions;Patients;Performance;Phenotype;point of care;Population;Population Heterogeneity;portability;Postdoctoral Fellow;Prevalence;prevent;primary care clinic;Process;prospective;Provider;Randomized, Controlled Trials;recruit;Research;Resource-limited setting;Retrospective cohort;Risk;screening;Screening procedure;screening program;self supervised learning;Signal Transduction;simulation;skills;Specialized Center;spectrograph;Structure;sudden cardiac death;Technology;Testing;Time;tool;Training;two-dimensional;Two-Dimensional Echocardiography;Ultrasonography;ultrasound;underserved community;user-friendly;vision science;wearable device

PROJECT_TITLE: A multi-modal approach for efficient, point-of-care screening of hypertrophic cardiomyopathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ORG_CITY: BEDFORD

ORG_NAME: EDITH NOURSE  ROGERS MEMORIAL VETERANS HOSPITAL

PHR: The VA has considered promoting increased use of lithium (LI) and clozapine (CLOZ) to prevent suicidal behavior. This study will analyze VA databases to greatly advance understanding of LI and CLOZ safety, and conduct a nationwide survey of VA MH prescribers about barriers and facilitators to LI and CLOZ use. VA databases contain far more LI users than previously studied, allowing crucial issues to be evaluated. These include identifying which patient groups would be the safest to target for increased use, and whether existing treatments and dosing strategies should be more widely used to prevent serious side effects. Findings will be summarized for Program Partners and providers, including in a user-friendly Guide and Patient-Provider Communication Tool prepared with the assistance of an Advisory Board of Veterans, VA leadership, providers, and subject experts. The survey will identify factors that might interfere or assist efforts to increase LI and CLOZ use. This state-of-the-art study will greatly enhance any future VA efforts to expand LI and CLOZ use.

PI_NAMEs: SMITH, ERIC G. (contact)

PROJECT_TERMS: Address;Age;anti-depressive agents;Area;Attitude;Behavior Therapy;behavioral health;Benefits and Risks;Caring;Characteristics;Clinical;clinical care;Clozapine;cohort;Communication;Communication Tools;comparison control;Control Groups;dashboard;Data;Databases;Development;Diagnosis;Dose;Electronic Mail;Ensure;evidence base;Formulation;Frequencies;Future;Goals;Health;implementation trial;improved;Incidence;informant;interest;Kidney;Knowledge;Leadership;Lithium;male;Medical;Mental Health;Mental Health Services;Metabolic;Metformin;Methodology;Monitor;mortality;Patient Care;patient subsets;patient-clinician communication;Patients;Pharmaceutical Preparations;pharmacy benefit;pilot test;policy implication;policy recommendation;Population;Predictive Analytics;predictive modeling;preference;prevent;Prevention strategy;preventive intervention;programs;Provider;provider behavior;randomized trial;Reporting;response;Risk;Risk Estimate;Risk Factors;risk minimization;risk mitigation;Safety;Serious Adverse Event;sex;side effect;Stratification;Structural Models;Subgroup;substance use;success;suicidal behavior;Suicide prevention;Surveys;Survival Analysis;Time;tool;treatment strategy;user-friendly;Veterans;Weight;willingness;ziprasidone

PROJECT_TITLE: Identifying Best Practices for Medication-Based Suicide Prevention Strategies to Minimize the Risk of Medically-Serious Adverse Events


PHR: PROJECT NARRATIVE Disruption of mitochondrial dynamics and quality control are key components of leading causes of disability, such as cerebrovascular disease and age-related neurodegeneration. The proposed research aims to investigate the contributions of dysfunctional mitochondrial quality control to cerebral ischemia/reperfusion injury, as well as the onset and progression of neurodegenerative disease. Utilizing innovate molecular and computational techniques, these studies will advance our understanding of mitochondrial dysfunction and inform the development of future therapeutics.

PI_NAMEs: FOGO, GARRETT MCGUIRE (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: active control;Affect;age related;age related changes;age related neurodegeneration;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;analysis pipeline;Architecture;Bioenergetics;Biogenesis;biological adaptation to stress;Biology;Blood flow;Brain;Cause of Death;Cell Death;Cells;Cerebral Ischemia;cerebrovascular;Cerebrovascular Disorders;Characteristics;Classification;Complex;Computational Technique;Computer Models;computerized tools;conditional knockout;cost;deprivation;Development;disability;Disease;Elements;energy efficiency;Ensure;Event;experimental study;Exposure to;Functional disorder;Future;Glucose;Homeostasis;Image;Imaging Device;Impaired cognition;in silico;In Vitro;in vitro Model;Individual;Injury;innovation;Investigation;Investments;Ischemia;Knock-out;live cell imaging;Machine Learning;Mammalian Cell;Mediating;Metabolic dysfunction;Methods;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modeling;Molecular;Morphology;Mus;Nature;Nerve Degeneration;Nervous System Disorder;Nervous System Trauma;Neurodegenerative Disorders;neurological pathology;Neurons;normal aging;novel;Nutrient;oxidation;Oxidative Stress;Oxygen;Parkinson Disease;Pathologic;Pathology;Pattern;Phase;Phenotype;Physiological;Postdoctoral Fellow;pre-doctoral;preservation;Process;Production;Protein Dynamics;Proteomics;proteostasis;Quality Control;real-time images;Reperfusion Injury;Reperfusion Therapy;Reporter;Reporter Genes;Reproducibility;Research;Respiration;Risk Factors;Role;simulation;skill acquisition;Swelling;Synapses;System;Technical Expertise;Technology;temporal measurement;Testing;Therapeutic;Therapeutic Intervention;Time;timeline;tool;Transgenic Organisms;United States;Work

PROJECT_TITLE: Exploring the mechanisms of dysfunctional mitochondrial quality control in cerebrovascular disease and the aging brain


ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PI_NAMEs: FARBER, DONNA L. (contact);SIMS, PETER ALAN

PROGRAM_OFFICER_NAME: HODGE, DEBORAH


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Data Science

PHR: Narrative This cloud-based learning module will provide trainees with a comprehensive introduction to best practices in data exploration, analysis, and visualization. It emphasizes generating reproducible workflows and focuses on the statistical principles common to large ’omic data sets. Through this module, trainees will gain practical skills and knowledge necessary for handling complex datasets, enabling them to conduct more informed and effective pharmacological research.

PI_NAMEs: KUHN, CYNTHIA M (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TITLE: Data Science Foundations: Tools and Statistics for Modern Biomedical Research in the Cloud

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Our proposal exemplifies how identification of neural circuit mechanisms by which adult-born neurons contribute to memory may edify new strategies to improve social memory in aging and MCI

PI_NAMEs: SAHAY, AMAR  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Adult;Affect;age related;Age-associated memory impairment;aged;Aging;aging related;aging reversal;Behavioral Paradigm;candidate validation;Cells;CHD7 gene;Chromatin;Cognitive;Communities;Coupling;Data;dentate gyrus;design;Development;Discrimination;Episodic memory;experience;Female;Frequencies;gain of function;Genetic;genetic approach;Goals;Grant;granule cell;Hippocampus;Human;Hyperactivity;Hypothalamic structure;Impairment;improved;in vivo;Interneurons;male;Maps;Mediating;Memory;memory consolidation;Memory impairment;Memory Loss;memory process;memory recognition;middle age;mild cognitive impairment;Molecular;Molecular Profiling;Mus;neural circuit;neurogenesis;neuronal excitability;Neurons;Neurosciences;nonhuman primate;novel;old mice;optogenetics;overexpression;Parvalbumins;patch clamp;Play;Prefrontal Cortex;programs;Property;Publishing;recruit;Resources;response;ribosome profiling;Rodent;Role;Route;Site;social;Testing;tool;Update;Viral

PROJECT_TITLE: Targeting neurogenesis-inhibition coupling to improve memory in aging


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Mental Health;Pediatric

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative This document has not changed from the original submission and is not required by PA-23-189.

PI_NAMEs: PEREZ-EDGAR, KORALY E (contact);PERLMAN, SUSAN B

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TITLE: Parent-to-child anxiety transmission in early childhood: Capturing in-the-moment mechanisms through emotion modeling and biological synchrony

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ORG_CITY: ROCHESTER

ORG_NAME: OAKLAND UNIVERSITY

ORG_STATE: MI

PHR: This application is for an administrative supplement to the parent R15 research award (1R15GM147857-01). We request supplemental funds to purchase the Biological Incubator (Model I-36NL, Geneva Scientific) to replace the broken incubator, which is essential for completing the parent project. The successful completion of this project will help further our knowledge of centrosome biology and cell division in humans with broad and important healthcare related to human cancers, ciliopathies, and developmental defects.

PI_NAMEs: SONG, MI HYE  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: 11 year old;26S proteasome;Administrative Supplement;Affect;anaphase-promoting complex;Award;Biochemical;Biological;Biological Models;Biology;Brain;Caenorhabditis elegans;Cell Cycle;Cell division;Centrioles;Centrosome;ciliopathy;Compensation;CRISPR/Cas technology;daughter cell;Defect;Development;Disease;Embryo;Ensure;Equipment;equipment acquisition;Exhibits;Funding;Genetic;genetic analysis;Genetic Models;genome editing;genome integrity;Genomic Instability;Goals;Healthcare;Homeostasis;Human;human disease;imaging system;in vivo;in vivo Model;Incubators;Knowledge;Malignant Neoplasms;Mediating;Microcephaly;Microtubule-Organizing Center;Modeling;Molecular Analysis;Monitor;Mus;mutant;Mutation;nano;National Institute of General Medical Sciences;parent project;Parents;Predisposition;Proteins;Proteolysis;Quantitative Microscopy;recruit;Regulation of Proteolysis;Request for Proposals;Research;Role;success;System;Temperature;Testing;Therapeutic Intervention;transmission process;tumorigenesis;ubiquitin ligase;ubiquitin-protein ligase;Work

PROJECT_TITLE: Administrative Supplements for Equipment Purchase: The Temperature-Controlled Incubator


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: FORT COLLINS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Non-learned defensive behaviors are necessary for survival, like fleeing or freezing in the face of threat. How these behaviors are changed depending on the circumstances, however, is not known. We will test whether the cerebellum, a brain region involved in the coordination of movement, modulates defensive behaviors.

PI_NAMEs: VAAGA, CHRISTOPHER EDWARD (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Amygdaloid structure;Animals;Behavior;behavior change;Behavior monitoring;Behavioral;behavioral outcome;behavioral response;Biological Assay;Brain region;Cerebellar Nuclei;Cerebellum;Complex;conditioned fear;Conditioned Stimulus;Coupled;Dedications;Detection;Dopamine;dopaminergic neuron;Environment;experimental study;fear memory;Fiber;flexibility;Foundations;Freezing;Fright;Goals;habituation;Heterogeneity;Impairment;in vivo;induced pluripotent stem cell;Interneurons;Learning;Lesion;Medial;midbrain central gray substance;Midbrain structure;Monitor;Motor Neurons;Movement;Mus;Muscle;Nature;neural circuit;Neurons;Optics;optogenetics;Output;Pattern;Photometry;Play;Predatory Behavior;Property;response;Role;sex;Signal Transduction;Source;Synapses;System;Techniques;Testing;Wild Type Mouse;Work

PROJECT_TITLE: Cerebellar Modulation of Innate Defensive Behaviors

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: TOLEDO

ORG_NAME: UNIVERSITY OF TOLEDO

ORG_STATE: OH

PHR: PROJECT NARRATIVE MTFR2 is unique among well-known mitochondrial fission/fusion regulators that it is co-expressed with multiple key mitosis genes. Characterizing the functional consequences of altered MTFR2 expression and MTFR2 cancer-occurring variants will reveal novel insights into chromosomal instability and taxol resistance.

PI_NAMEs: LIU, SONG-TAO  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Affect;Biological Process;cancer cell;Cell Cycle;Centromere;Chromosomal Instability;chromosome missegregation;Chromosome Segregation;Chromosomes;CRISPR/Cas technology;Data;daughter cell;Defect;Ensure;experience;experimental study;Genes;Genetic Transcription;hands on research;Heterogeneity;insight;interest;Kinetochores;Knock-out;Malignant Neoplasms;Microtubules;Mitochondria;Mitosis;Mitotic;Mitotic spindle;Names;novel;Paclitaxel;Play;prevent;Regulation;Resistance;Role;Training;undergraduate student;Universities;Variant;Work

PROJECT_TITLE: MTFR2 in the control of mitochondrial dynamics and mitotic spindle integrity


NIH_SPENDING_CATS: Neurosciences

ORG_STATE: MA

PHR: Project Narrative There are a dearth of opportunities for students from underrepresented backgrounds to obtain specialized post-baccalaureate training in neuroscience, though such training is becoming increasingly important for admission to top neuroscience PhD programs. Here, we propose further development of PiNBAC, a post- baccalaureate program launched in 2021 with significant mentorship, research and educational components housed in the Harvard Medical School Department of Neurobiology, and affiliated with the T32-funded Harvard PhD Program in Neuroscience. Early program outcomes suggest that PiNBAC is an effective approach to train a diverse neuroscience workforce by preparing talented trainees from underrepresented groups for successful application to, and success within, competitive PhD programs to continue their training.

PI_NAMEs: ASSAD, JOHN  (contact);TAN, TARALYN MARIE

PROJECT_TERMS: Address;Admission activity;Brain;Data;Development;Disparity population;Doctor of Philosophy;Education;Education Gap;education resources;Educational Curriculum;experience;falls;Feedback;Funding;Future;graduate school;higher education;innovation;Learning;longitudinal course;matriculation;medical schools;Mentors;Mentorship;Neurobiology;Neurosciences;Neurosciences Research;next generation;Outcome;Participant;pedagogical content;peer;Population;Postbaccalaureate;programs;Research;Role;Science;Students;success;Surveys;Talents;Training;Training and Infrastructure;Training Programs;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Work

PROJECT_TITLE: PiNBAC: The Program in Neuroscience Post-Baccalaureate Training Program


NIH_SPENDING_CATS: Autism;Brain Disorders;Fragile X Syndrome;Genetics;Infectious Diseases;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Rare Diseases

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Maquat-lab research focuses on RNA metabolism in human health and disease. The lab’s view is that understanding the molecular mechanisms of normal gene expression and what goes wrong with these mechanisms in disease are critical for the development of effective therapeutics. Disease states to be examined include fragile X syndrome, which is the most common single-gene cause of intellectual disability and autism, and a runaway innate immune response, which can lead to a cytokine storm in cases of bacterial or viral infections, including COVID-19.

PI_NAMEs: MAQUAT, LYNNE E (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Affect;autism spectrum disorder;Bacterial Infections;Binding;Biological Process;Biology;boys;Cardiomyopathies;Categories;Cell Nucleus;Cell Physiology;Cells;Complex;COVID-19;cytokine release syndrome;Cytoplasm;Development;Disease;Environment;Etiology;Exons;fascinate;Fragile X Syndrome;Frameshift Mutation;Gene Expression;Genes;Genetic;Genetic Transcription;girls;Goals;Health;Hereditary Disease;Human;human disease;Immune response;In Vitro;Inherited;Innate Immune Response;insight;Intellectual functioning disability;interest;Mammalian Cell;Mediating;Messenger RNA;Metabolism;Mitochondria;Molecular;mRNA Decay;mRNA Precursor;mRNA Translation;Mus;Muscle Fibers;Neuromuscular Diseases;Nonsense Codon;Nonsense Mutation;Nuclear;Outcome;Pathogenesis;Pharmacotherapy;prevent;Production;protein function;Proteins;Research;Research Personnel;RNA Cap-Binding Proteins;RNA metabolism;RNA Polymerase III;RNA Splicing;RNA-Binding Proteins;Role;Runaway;sarcopenia;therapeutically effective;Time;Transcription Coactivator Gene;Translations;Virus Diseases;Work

PROJECT_TITLE: Nonsense-mediated mRNA decay and beyond