NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Breast Cancer;Cancer;Climate-Related Exposures and Conditions;Clinical Research;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Rural Health;Skin Cancer;Social Determinants of Health;Urologic Diseases;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE A retrospective case-control pilot study examines the association between chronic arsenic, cadmium, lead, uranium and nitrate in water and cancer outcomes in an American Indian community. The goal of this pilot project is to develop and implement an exposure assessment tool to use now and in the future to examine the association between exposures and a range of adverse health outcomes. This study has the potential to augment prevention efforts, intervention, education, monitoring, support policy development and legislation, and address longstanding cancer disparities and improve outcomes.

PI_NAMEs: SAMUEL-NAKAMURA, CHRISTINE  (contact)

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: Address;Age;Air;American Indian community;American Indian Tribe;American Indians;anthropogenesis;Apache;Apache Tribe;Area;Arizona;Arsenic;Asbestos;Assessment tool;Behavioral Sciences;Biological Models;Bladder;Breast;Cadmium;cancer diagnosis;cancer health disparity;Carcinogens;Cardiovascular Diseases;case control;Chronic;Clinical Sciences;Communities;Consumption;Copper;County;Data;Death Rate;design;Diabetes Mellitus;Dose;drinking water;Education;Elements;Enrollment;Environment;Excess Mortality;Exposure to;Female Breast Carcinoma;Food;Foundations;Future;General Population;Geographic Information Systems;Geological Survey;Geology;Goals;Grant;Health;Health care facility;health record;Health Resources;Health Services;Healthcare;high risk;improved;improved outcome;Incidence;Ingestion;International Agency for Research on Cancer;International Classification of Disease Codes;intertribal;Intervention;Intervention Studies;Investigation;Kidney;Knowledge;Lead;Link;Literature;Logistic Regressions;Lung;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Maps;Medical;Melanoma;Metal exposure;Metals;Mining;Mission;Monitor;mortality;Movement;neoplasm registry;Nitrates;Non-accidental;novel;Odds Ratio;Outcome;Persons;Pilot Projects;Policy Developments;poor communities;Population;Prevention;Privatization;Prostate;Recording of previous events;Records;Renal Carcinoma;Reporting;reproductive outcome;Research Personnel;Reservations;Resource Allocation;Resources;response;Risk;Rural Community;Scientific Advances and Accomplishments;Scientist;Screening for cancer;sex;Silver;Skin;Skin Cancer;Social Sciences;Soil;Source;Statutes and Laws;suburban communities;Surveillance Program;System;Testing;Time;Training;Tribal Council;tribal health;tribal healthcare;tribal leader;tribal member;Tribes;underserved community;Underserved Population;United States Environmental Protection Agency;United States Indian Health Service;Uranium;urinary;Water;Water Pollutants;water quality;well water;Work

PROJECT_TITLE: Arsenic and other co-metals in the San Carlos Apache drinking water

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: DC

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

ORG_STATE: MA

PHR: PROJECT NARRATIVE  The overall goals of this Center are to (1) identify integrated features of clinical, behavioral and neural characteristics that reflect overlapping and distinct pathophysiology of laryngeal dystonia and voice tremor, and (2) develop predictive analytics for differential diagnosis of these disorders. This research is relevant to public health because it is expected to advance the understanding of the disorder pathophysiology and help define new approaches for their clinical management. Thus, the proposed research is relevant to NIH’s mission that pertains to developing fundamental knowledge that will help reduce the burdens of human disability.

PI_NAMEs: SIMONYAN, KRISTINA  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: accurate diagnosis;Address;Affect;Animal Model;Behavioral;botulinum neurotoxin injection;Brain;Brain imaging;California;Characteristics;Clinical;clinical care;Clinical Data;clinical decision-making;clinical examination;Clinical Management;clinical phenotype;Clinical Research;Collaborations;Communication;Complex;Data;Data Science;Deep Brain Stimulation;Development;Diagnosis;diagnostic criteria;Differential Diagnosis;disability;Disease;Disease Management;Dystonia;Ear;early detection biomarkers;effective therapy;Effectiveness;Epidemiology;Essential Tremor;Eye;Functional disorder;General Hospitals;Goals;Human;Image;Impairment;improved;Infrastructure;Institution;Investigation;Knowledge;Laryngeal muscle structure;Larynx;Life;Link;Machine Learning;Massachusetts;Measures;Methodology;Methods;Mission;Monitor;Motor;Movement Disorders;multimodality;Nervous System Disorder;neural;neural circuit;neuroimaging;Neurology;neurophysiology;neuroregulation;Neurosciences;neurosurgery;next generation;novel strategies;Occupational;Operative Surgical Procedures;Otolaryngology;Outcome Assessment;Patients;phenomenological models;Phenotype;Predictive Analytics;Production;programs;Public Health;Quality of life;Recommendation;Records;Research;Research Personnel;research study;San Francisco;shared repository;Site;Social isolation;Spastic Dysphonias;Speech;Speech Acoustics;Speech-Language Pathology;Stratification;symptom management;symptomatology;Symptoms;Testing;tool;Translating;Treatment Efficacy;treatment planning;Tremor;United States National Institutes of Health;Universities;Utah;Voice

PROJECT_TITLE: Next-generation clinical phenotyping and pathophysiology of laryngeal dystonia and voice tremor


NIH_SPENDING_CATS: Behavioral and Social Science;Dystonia;Neurodegenerative;Neurosciences;Rare Diseases

PROJECT_TERMS: Adherence;Administrator;Advisory Committees;Budgets;Clinical;clinical phenotype;Clinical Trials;Collaborations;collaborative environment;Communication;Communities;Data Collection;data sharing;Decision Making;Diagnostic;Doctor of Philosophy;Effectiveness;Ensure;expectation;Expenditure;Functional disorder;Funding;Goals;human subject;innovation;Institution;Institutional Review Boards;Intellectual Property;interest;Knowledge;Language;Mediating;meetings;member;Monitor;National Institute on Deafness and Other Communication Disorders;neuroimaging;Neurologic Voice Disorder;Neurology;neurosurgery;next generation;operation;organizational structure;Otolaryngology;patient outreach;Patients;Persons;Policies;Production;Progress Reports;Publications;Records;Research;Research Activity;Research Personnel;Resources;Science;Scientist;Site;Spastic Dysphonias;Speech;Speech-Language Pathology;success;Technology Transfer;translational potential;Translational Research;Tremor;United States National Institutes of Health;virtual;Voice;Work

PROJECT_TITLE: Administrative Core


PHR: PROJECT NARRATIVE  This project will systematically evaluate current and novel clinical voice assessment tools and measures to elucidate distinct clinical phenotypes of those with laryngeal dystonia and voice tremor. Outcomes of this work will advance scientific knowledge about disorder-specific characteristics of laryngeal dystonia and voice tremor and advance evidence-based clinical assessment methods that increase the accuracy of diagnosis in those with LD and VT. Thus, the proposed research is relevant to NIH’s mission that pertains to developing fundamental knowledge that will help reduce the burdens of human disability.

PROJECT_TERMS: accurate diagnosis;accurate diagnostics;Acoustics;Affect;Agreement;Assessment tool;Auditory;Behavior;Breathing;Characteristics;Classification;Clinical;Clinical assessments;clinical phenotype;clinical predictors;cohort;Computer Models;Consensus;demographics;Diagnosis;diagnostic accuracy;diagnostic strategy;Differential Diagnosis;disability;Disease;Dystonia;effective therapy;Epidemiology;Essential Tremor;evidence base;Exhibits;experience;Frequencies;Functional disorder;Goals;Human;improved;Individual;insight;instrument;Intention Tremor;Interruption;kinematics;Knowledge;Larynx;Literature;Magnetic Resonance Imaging;Measurable;Measures;Medical;Medical History;Methods;Mission;Modeling;Movement;Movement Disorders;multidisciplinary;Neurologic;Neurologic Voice Disorder;Neurology;next generation;novel;Otolaryngologist;Otolaryngology;Outcome;Outcomes Research;Output;Participant;Patient Self-Report;patient stratification;Patients;Pattern;Periodicals;Periodicity;Phonation;Physiological;Production;Protocols documentation;Publishing;Questionnaires;Rare Diseases;Recording of previous events;Reporting;Research;research study;Sampling;Scientific Advances and Accomplishments;screening;Signal Transduction;sound;Spasm;Spastic Dysphonias;Specialist;Specificity;Speech;Speech Disorders;Speech-Language Pathology;Speed;Structure;Symptoms;Syndrome;Testing;Time;tool;treatment planning;Tremor;United States National Institutes of Health;Visual;vocal cord;Voice;Voice Disorders;Voice Quality;Work

PROJECT_TITLE: Characterization of clinical phenotypes of laryngeal dystonia and voice tremor


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Dystonia;Neurodegenerative;Neurosciences;Rare Diseases;Rehabilitation

PHR: PROJECT NARRATIVE  The proposed research aims to examine functional neural correlates that differentiate between laryngeal dystonia and voice tremor and contribute to disorder-specific pathophysiology using a cross-disciplinary approach of multimodal brain imaging. This research is relevant to public health because identification of neural changes contributing to distinct clinical manifestation of laryngeal dystonia and voice tremor is expected to advance the understanding of the disorder pathophysiology and help formulate new approaches for their clinical management. Thus, the proposed research is relevant to NIH’s mission that pertains to developing fundamental knowledge that will help reduce the burdens of human disability.

PROJECT_TERMS: Acoustics;Address;Affect;Anesthetics;auditory feedback;Behavioral;behavioral response;Behavioral trial;Brain;Brain imaging;Bupivacaine;Central Nervous System;Characteristics;Clinical;Clinical Management;clinical phenotype;Communication;Compensation;Congenital neurologic anomalies;Crying;Deformity;Differential Diagnosis;disability;Disease;Dysphonia;Dystonia;EEG-based imaging;Etiology;Event;experimental study;Feedback;Focal Dystonias;Functional disorder;Functional impairment;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Future;Goals;Human;Impairment;Intention Tremor;interdisciplinary approach;Knowledge;Laryngeal Mucosa;Larynx;Learning;Magnetic Resonance Imaging;Magnetoencephalography;Mission;Modeling;Motor;motor learning;Movement;multimodality;Nature;Nervous System Disorder;neural;neural correlate;neuroimaging;Neurologic Voice Disorder;Neuronal Plasticity;next generation;noninvasive brain stimulation;novel strategies;Patients;Peripheral;Phonation;Populations at Risk;Process;Production;Public Health;reduce symptoms;Research;response;Role;screening;sensory feedback;sequence learning;somatosensory;Spastic Dysphonias;Speech;temporal measurement;Therapeutic;Tremor;United States National Institutes of Health;Voice

PROJECT_TITLE: Understanding disorder-specific neural pathophysiology in laryngeal dystonia and voice tremor


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Clinical Research;Dystonia;Neurodegenerative;Neurosciences;Rare Diseases;Rehabilitation

PHR: PROJECT NARRATIVE  Loss of voice control, which is critical for conveying effective spoken communication, is often a significant symptom in patients with movement disorders. The goals of this project are 1) to determine the incidence of neurological voice disorders in patients with dystonia and essential tremor undergoing deep brain stimulation (DBS), 2) investigate the neuroimaging and intracranial neurophysiology correlates of voice dysfunction in these subjects, and subsequently 3) determine the effects of DBS on voice function. This research is relevant to NIH’s mission that pertains to developing fundamental knowledge that will help reduce the burdens of human disability.

PROJECT_TERMS: Architecture;Area;awake;Basal Ganglia;Brain;Bypass;Caring;Classification;Clinical;clinical phenotype;clinical practice;Clinical Trials;Communication;comorbidity;Data;Deep Brain Stimulation;design;Development;Diagnosis;disability;Disease;Dorsal;Dystonia;Electric Stimulation;Electrocorticogram;Electroencephalography;Equipment;Essential Tremor;Evaluation;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Human;Image;Impairment;implantation;improved;Incidence;Individual;Inferior;Knowledge;Larynx;Limb Dystonia;Limb structure;Limb Tremors;Lobule;Location;Maps;Measures;Mission;motor behavior;Motor Cortex;motor symptom;Movement Disorders;multidisciplinary;multimodality;neural;neural correlate;neural network;neuroimaging;Neurologic;Neurologic Voice Disorder;neurophysiology;Neurosciences;Neurosurgeon;next generation;non-invasive imaging;Operative Surgical Procedures;Outcome;Parietal;Participant;Pathway Analysis;Patients;Phenotype;phenotypic data;Physiology;Postoperative Period;Prevalence;Production;Protocols documentation;Quality of life;Reporting;Research;Research Personnel;response;Scalp structure;sensory cortex;Site;Spastic Dysphonias;Speech;Standardization;Structure of supramarginal gyrus;Symptoms;Techniques;Testing;Thalamic structure;Tremor;United States National Institutes of Health;Voice;Voice Disorders;Work

PROJECT_TITLE: Deep Brain Stimulation in Laryngeal Dystonia and Voice Tremor


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Data Science;Dystonia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Rare Diseases

PHR: PROJECT NARRATIVE  The Next-Generation Clinical Research and Data Science Core will provide a centralized data repository for all clinical and research data collected during the proposed studies of the Center. The Core will also provide the analytical support and develop advanced machine-learning algorithms for predictive assessment models of laryngeal dystonia and voice tremor. As such, the Core will serve and support all Center sites and projects for data acquisition, sharing, and analysis.

PROJECT_TERMS: Adherence;analytical tool;Audiology;Behavioral;Biological Markers;Biometry;Blood specimen;Brain imaging;California;Characteristics;Clinical;Clinical Data;clinical database;clinical phenotype;Clinical Research;Clinical Sciences;cohort;Collection;computerized data processing;Data;data acquisition;Data Analyses;Data Analytics;data anonymization;Data Collection;data harmonization;data repository;Data Science;Data Science Core;data sharing;data standards;data submission;data tools;Development;Diagnostic;diagnostic biomarker;Differential Diagnosis;Disease;Ear;Electromyography;Ensure;Evaluation;Eye;Functional disorder;Future;General Hospitals;Genotype;Image;investigator training;kinematics;Larynx;Link;machine learning algorithm;machine learning prediction algorithm;Massachusetts;Modeling;Monitor;multimodality;neuroimaging;Neurologic;neuropsychiatry;next generation;Outcome Study;Participant;Patients;Peripheral;Phenotype;Protocols documentation;Psychophysics;Questionnaires;recruit;repository;Research;Research Activity;Research Personnel;Resource Sharing;respiratory;Risk Factors;San Francisco;screening;Severities;shared repository;Site;Spastic Dysphonias;Speech;Speech Acoustics;Standardization;Symptoms;Testing;tool;Treatment outcome;Tremor;Universities;Utah;Voice

PROJECT_TITLE: Research Core


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD)

ORG_DEPT: MISCELLANEOUS

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE Characterization of chromatin interactions and higher-order nuclear organization will be important for a better understanding of gene regulation in disease processes. We will develop a platform for data collection, curation, visualization, and analysis. This will enable data sharing and integrative analysis of the massive amounts of data that will be generated in the 4D Nucleome Network.

PI_NAMEs: PARK, PETER J (contact)

PROGRAM_OFFICER_NAME: HANLON, SEAN E

PROJECT_TERMS: 3-Dimensional;Acceleration;Architecture;Authorization documentation;Awareness;Biological;Biological Assay;Cell Nucleus;centralized portal;Chromatin;cloud platform;Collection;Communication;Communities;computational pipelines;Computer software;computerized data processing;Controlled Environment;Cost efficiency;Data;data access;data acquisition;data analysis pipeline;Data Collection;data curation;data dissemination;Data Files;data management;data modeling;data platform;data portal;Data Protection;data resource;Data Set;data sharing;data standards;data submission;data tools;data visualization;Deposition;design;Development;Disease;Educational workshop;Ensure;epigenomics;experience;flexibility;Funding;Gene Expression Regulation;genomic data;Genomics;Goals;Health;Human;Image;image processing;improved;Intake;International;Language;Maintenance;Maps;meetings;member;Metadata;metadata standards;Microscopy;Monitor;multimodal data;novel;Nuclear;Ontology;open data;outreach;Phase;Positioning Attribute;Process;Protocols documentation;Quality Control;Reproducibility;Research;Research Activity;Research Personnel;Research Support;Resources;Role;Sampling;Scientist;Secure;self organization;software development;Structure;symposium;System;Technology;Time;tool;United States National Institutes of Health;user-friendly;Vision;Visualization;Visualization software;webinar;Work;working group

PROJECT_TITLE: 4D Nucleome Network Data Coordination and Integration Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T(50)R]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: CORAL GABLES

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE Racial and gender underrepresentation in biomedical research continue to be a major challenge in tackling many diseases, and this is especially true for those that fall under the NIDDK mission, which include diabetes, obesity, and chronic kidney disease. Capitalizing on the talents, insights, and interests of diverse groups of scientists are critical to addressing acute and chronic diseases that impact the health and prosperity of many Americans. We propose a workshop and coaching program to support and advise NIDDK awardees from underrepresented minorities at early career stages to foster their professional development and promote their impactful careers addressing disease mechanisms and therapeutic interventions.

PI_NAMEs: AGARWAL, ASHUTOSH ;FORNONI, ALESSIA  (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Acute Disease;Address;American;Applications Grants;Area;Award;Basic Science;Biomedical Research;career;career development;Chronic Disease;Chronic Kidney Failure;Clinical;Clinical Research;cohort;Collaborations;combat;Course Content;Data;Dedications;design;Development;Diabetes Mellitus;Disease;Educational Curriculum;Educational workshop;Effectiveness;effectiveness evaluation;empowerment;Ensure;Environment;Equilibrium;Ethnic Origin;Evaluation;experience;Faculty;Fostering;Foundations;Funding;Funding Mechanisms;Gender;Goals;Grant;Health;Healthcare Systems;Home;Individual;infancy;insight;Institution;Instruction;interest;Joints;Knowledge;Life;Logic;Manuscripts;Mediation;medical schools;Mentors;microaggression;Mission;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;Needs Assessment;next generation;Obesity;Online Systems;Outcome;Output;Participant;Patient Care;Peer Review;Postdoctoral Fellow;Preparation;Process;Productivity;Professional Competence;Program Development;Program Effectiveness;programs;Publications;Publishing;Race;racial diversity;Research;Research Personnel;Resource Sharing;Resources;response;Rewards;satisfaction;Scholars Program;Scientist;Shapes;Site;skill acquisition;skills;social;Solid;success;Surveys;symposium;synergism;Talents;Telephone;Therapeutic Intervention;Time Management;Training;Transferable Skills;Translational Research;translational scientist;Trust;Underrepresented Minority;United States National Institutes of Health;Universities;web site;Woman;Work

PROJECT_TITLE: Workshops and Coaching to Foster Career Skills in Newly Funded NIDDK Scholars


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric;Physical Activity;Serious Mental Illness;Social Determinants of Health;Teenage Pregnancy;Telehealth;Women's Health Research

ORG_CITY: WASHINGTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Untreated postpartum depression impacts maternal morbidity and mortality and has long-term impacts on children's survival, mental and health physical health, and development. We will refine development of a digital platform that can be used by non-specialists to improve delivery of psychological interventions for postpartum depression by incorporating passive sensing data collected from a mobile phone and passive Bluetooth beacon with the mother and her infant. Successful completion of this study will lead to a full trial of the digital platform, and contribute to NIMH goals of digital phenotyping and promoting scalable interventions.

PI_NAMEs: GAUTAM, KAMAL ;KOHRT, BRANDON ALAN (contact);VAN HEERDEN, ALASTAIR

PROGRAM_OFFICER_NAME: SCOTT-SHELDON, LORI ANN JENNIFER

PROJECT_TERMS: Accelerometer;Acute;Anthropology;arm;behavior change;Behavior monitoring;Behavioral;behavioral and social science;Biometry;Bluetooth;Cellular Phone;Child;child depression;Clinical Research;community advisory board;Community Health Aides;convolutional neural network;Data;Data Analyses;Data Collection;Development;Devices;digital mental health;digital phenotyping;digital platform;digital technology;Educational workshop;Effectiveness;Enrollment;experimental arm;Exposure to;Family member;Geography;Global Positioning System;Goals;Health;health economics;Health system;Healthcare;Human;human centered design;Husband;implementation cost;implementation science;improved;Infant;Information Technology;innovation;Internet of Things;Intervention;intervention cost;Learning;Life;literacy;low and middle-income countries;Machine Learning;maternal depression;maternal morbidity;Maternal Mortality;Measurement;Mental Depression;Mental disorders;Mental Health;mHealth;mhealth interventions;mobile application;Modernization;Monitor;Mothers;Movement;National Institute of Mental Health;Nepal;Outcome;Pattern;Phase;Physical activity;physical conditioning;Policies;Population Heterogeneity;post intervention;Postpartum Depression;Prevalence;Principal Component Analysis;privacy preservation;Process;Professional counselor;Psyche structure;Psychiatry;psychologic;Qualitative Research;Randomized;Randomized, Controlled Trials;Readiness;recruit;Research;Resource-limited setting;Risk;Safety;sensor;sensor technology;Services;smart watch;Social Environment;sound;South Africa;Speech;Strategic Planning;Suicide;Technology;teenage mother;Testing;Theory of Change;therapy development;Time;treatment as usual;treatment planning;trial comparing;usability;Visualization;wearable device;willingness;Work;young mother

PROJECT_TITLE: Sensing Technologies for maternal depression treatment in low resource settings (StandStrong)

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Genetics;Lung;Orphan Drug;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Understanding which endothelial subpopulations and signaling pathways are responsible for the development of pulmonary arteriovenous malformations (PAVM) will help us develop medical therapies to prevent, arrest and potentially regress PAVMs. We will test two repurposed drugs, Tacrolimus (FK506) and Enzastaurin, as well as novel drugs predicted in silico (ie Brivanib) in our novel mouse model of PAVM in vivo as well as in in vitro in induced pluripotent stem cell derived endothelial cells (iPSC-ECs) as well as organ cultures from HHT patients. Given that these three drugs are ready to be tested in clinical trials, our research is in line with the NIH’s mission to increase knowledge and enhance health, lengthen life, reduce illness and disability by applying fundamental knowledge to diseases without a cure.

PI_NAMEs: SPIEKERKOETTER, EDDA FRAUKE (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Ablation;Abnormal Endothelial Cell;Adult;Animal Model;Apoptosis;Arteries;Arteriovenous malformation;autosome;Blood capillaries;BMPR2 gene;Brain;Bypass;capillary bed;Catheters;cell behavior;Cell Physiology;cell type;Cells;Cerebral Abscesses;Child;Childhood;Clinical Trials;clinically relevant;Color;common symptom;Conceptions;CRISPR correction;Data;Development;disability;Disease;disease model;Dominant Genetic Conditions;drug candidate;drug development;drug repurposing;Endoglin;Endothelial Cells;Endothelium;Epistaxis;Event;FK506;Fluorescent in Situ Hybridization;Functional disorder;Gastrointestinal tract structure;Genes;Genetic Diseases;Growth;Growth and Development function;Health;Hemorrhage;Hereditary hemorrhagic telangiectasia;Heterozygote;high throughput screening;high-throughput drug screening;Human;Image;improved;in silico;In Vitro;in vivo;induced pluripotent stem cell;innovation;Intervention;knock-down;Knowledge;Label;lead candidate;Life;Liver;loss of function mutation;Loss of Heterozygosity;Lung;lung imaging;lung microvascular endothelial cells;MADH4 gene;Maps;Mediating;Medical;Migraine;Mission;Molecular;Molecular Target;Morbidity - disease rate;mortality;mortality risk;mouse model;Mus;Mutation;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Organ;Organ Culture Techniques;Pathologic;Pathway interactions;Patients;Penetrance;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiologic pulse;Population;postnatal;Preclinical Testing;Prevalence;prevent;Prevention;Proliferating;pulmonary arterial hypertension;pulmonary arteriovenous malformation;Radiation exposure;Reperfusion Therapy;Research;Resolution;Risk;Role;Signal Pathway;Signal Transduction;single molecule;Skin;Slice;Small Interfering RNA;Stroke;Structure of mucous membrane of nose;Tacrolimus;Techniques;Telangiectasis;Testing;Therapeutic;Therapeutic Embolization;therapeutic evaluation;therapeutic target;Three-Dimensional Imaging;tissue culture;Tissues;tool;transcriptome sequencing;transcriptomics;Tube;United States National Institutes of Health;vascular bed;Vascular Endothelial Cell;Veins;Venous;Visceral

PROJECT_TITLE: Understanding and targeting molecular and cellular events responsible for pulmonary arteriovenous malformation development, growth and regression

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative Retinal cells are non-dividing cells, yet they need the machinery to synthesize complex molecules from simpler molecules to support retina structure and function. Our studies will investigate how this molecular machinery works in retinal cells in health and disease. Our long-term goal is to understand these mechanisms to design novel therapies to protect retinal structure and function in patients who suffer from retinal degeneration.

PI_NAMEs: RAJALA, RAJU VS (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Ablation;aerobic glycolysis;Affect;Affinity Chromatography;Age related macular degeneration;aged;Aging;aging related;Aldehyde-Lyases;Aldolase C;American;Anabolism;Antibodies;Antioxidants;Cell Physiology;Cells;Complex;design;Disease;DNA;Enzymes;experimental study;Gene Expression;Gene Expression Profile;Glucose;Glycolysis;Goals;Health;In Vitro;innovation;Interphase Cell;knock-down;Knockout Mice;Knowledge;Label;Light;lipid biosynthesis;Lipids;Mediating;Mediator;Messenger RNA;Metabolic;Metabolism;Mission;Molecular;mouse model;Mus;National Eye Institute;normoxia;novel;novel therapeutics;old mice;Outcome;Pathogenesis;Pathogenicity;Pathologic;Pathology;Patients;Phosphoenolpyruvate;Phosphorylation;Photoreceptors;prevent;Process;Protein Dephosphorylation;Protein Tyrosine Kinase;protein tyrosine phosphatase 1B;Proteins;Publications;Pyruvate;Pyruvate Kinase;Regulation;Retina;Retinal Degeneration;retinal rods;Rhodopsin;Ribosomes;RNA;Rod;Role;Signal Transduction;src-Family Kinases;Structure;Structure of retinal pigment epithelium;Techniques;Testing;Transcription Coactivator;Translating;tumor;Tyrosine Phosphorylation;United States National Institutes of Health;Vision;Warburg Effect;Work

PROJECT_TITLE: Regulators of Photoreceptor Aerobic Glycolysis in Retinal Health and Disease

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: NARRATIVE Several sight threatening diseases involve excessive cell and synapse removal by an important immune cell type called microglia. The goal of this work is to understand the molecular mechanisms that connect microglia function to their intracellular states. Results from this study will inform the longer- term goal of preventing vision loss by modulating microglia-dependent outcomes in eye diseases.

PI_NAMEs: SAMUEL, MELANIE A (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Adopted;Anus;Astrocytes;Biological Assay;Blindness;CD47 gene;cell motility;Cell Physiology;cell regeneration;cell type;Cells;Cessation of life;Cues;Data;Development;Diabetic Retinopathy;Disease;Disease Progression;Eating;Event;Excision;experimental study;Eye diseases;functional plasticity;Genetic;genetic manipulation;Genetic Transcription;Glaucoma;Goals;Health;Heterogeneity;Immune;Immune signaling;Knowledge;Ligands;Link;Macrophage;Mediating;Microglia;Molecular;molecular imaging;Mus;nanoscale;neonatal mice;Neurons;neurotransmission;novel;novel therapeutics;Outcome;overexpression;Pathology;Pathway interactions;permissiveness;Phagocytes;Phagocytosis;Phagocytosis Inhibition;Phosphatidylserines;Physiological;Play;Population;prevent;programs;Property;receptor;Retina;Retinal Degeneration;Retinal Diseases;retinal regeneration;Role;SHPS-1 protein;Signal Transduction;single cell sequencing;Specific qualifier value;Synapses;Testing;Therapeutic;Time;Variant;Vision;Work

PROJECT_TITLE: Microglial plasticity mechanisms in the developing retina


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Prevention;Social Determinants of Health

ORG_CITY: HERSHEY

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: Project Narrative Dietary intake of fruits and vegetables (F&V) is a cornerstone for the treatment of type 2 diabetes, however less than 16% of Hispanic adults consume the recommended number of servings each day. F&V prescription (F&V Rx) programs are embedded into clinical settings and provide patients with vouchers to purchase F&V at local retailers. The proposed study aims to test the effects of a F&V Rx on diabetes self-management education and support (DSME/S) uptake and retention, dietary intake of F&V and diet quality, glucose control (hemoglobin A1c), and program implementation outcomes.

PI_NAMEs: VELDHEER, SUSAN  (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: Address;Adult;aged;arm;blood glucose regulation;Calories;care providers;Caring;Carotenoids;Clinic;Clinical;clinical care;Clinical Trials;Communities;community advisory board;Consumption;Control Groups;cost;Data;design;Diabetes Mellitus;diabetes self-management;Diet;dietary guidelines;Dietary intake;Disease;Education;Enrollment;Ethnic Origin;Evaluation;Faculty;Fatty acid glycerol esters;Food;food insecurity;food security;fruits and vegetables;Future;glycemic control;Glycosylated hemoglobin A;group intervention;Healthy Eating;Hemoglobin;high risk;Hispanic;hispanic community;Hour;Household;implementation outcomes;implementation science;improved;Incentives;indexing;innovation;Intake;Intervention;Knowledge;Low income;Low Income Population;Measures;Medicaid;Medical;Methodology;Mind;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Nutrient;nutrition;Outcome;Participant;Pathway interactions;Patients;Pharmaceutical Preparations;Plasma;primary care clinic;Process;Proctor framework;Program Appropriateness;programs;Race;Randomized, Controlled Trials;Recommendation;Research;response;sex;sociodemographic factors;sociodemographics;sugar;Surveys;Taxonomy;Testing;treatment as usual;treatment planning;trial design;uptake;usual care arm;voucher;Work

PROJECT_TITLE: Veggie Rx: A pilot, 3-arm randomized controlled trial of a fruit and vegetable prescription program for patients with type two diabetes

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Digestive Diseases;Liver Disease

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative - MUSC HARP Program  This program promises to support the career developing of underrepresented in medicine (UIM) junior investigators and to promote of interdisciplinary exchange among mentors, junior investigators, and NIDDK leadership. The MUSC HARP Program in NIDDK Related Disease Areas will substantially augment thematic NIDDK related disease research on a national level. The founding efforts proposed here and in collaboration with the entire HARP group are expected to establish an effective, sustainable, and multidisciplinary career development program.

PI_NAMEs: ROCKEY, DON C. (contact)

PROJECT_TERMS: Acceleration;Applications Grants;Area;Basic Science;Biological;Biomedical Research;career;career development;Clinical;Clinical Sciences;Collaborations;Communities;Complex;Credentialing;cultural competence;Dedications;design;Development;Digestive System Disorders;Disabled Persons;Disease;Disparity;Education;Elements;Engineering;Ensure;Evaluation;experience;Faculty;Funding;Goals;implicit bias;improved;Infrastructure;innovation;Institution;Investigator-Initiated Research;K-Series Research Career Programs;Knowledge;Lead;Leadership;Liver diseases;Medical;medical schools;Medicine;Mentors;Mentorship;Minority;Mission;Motivation;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;online course;Outcome;Physicians;Population;population health;Positioning Attribute;Postdoctoral Fellow;Program Development;programs;Publications;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resources;role model;satisfaction;Scholars Program;Science;Scientist;skill acquisition;skills;South Carolina;Strategic Planning;success;sustainable resource;Talents;Testing;Time;Training;Training Programs;Underrepresented Minority;United States National Institutes of Health;Universities;Vision;Woman

PROJECT_TITLE: Medical University of South Carolina Mentoring Program in Digestive and Liver Diseases


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE, Overall The ultimate goal of the Colorado (CO) Head and Neck Cancer (HNC) SPORE is to advance translational research to improve survival and quality of life for HNC patients. The strategies to accomplish this goal will take advantage of our expertise in basic and clinical sciences and unique model systems to identify novel molecular and cellular mechanisms of HNC pathogenesis that may be targeted for therapeutic interventions.

PI_NAMEs: JIMENO, ANTONIO  (contact);WANG, XIAO-JING

PROGRAM_OFFICER_NAME: HUBBARD, LEAH

PROJECT_TERMS: Address;Anatomy;anti-cancer research;base;Basic Science;Biological Models;Biopsy;Breathing;cancer cell;Cancer Model;cancer survival;cancer therapy;cancer type;career;Caring;Cell Physiology;Cell Survival;Cells;chemoradiation;Clinic;clinical application;Clinical Sciences;Clinical Trials;Colorado;Combination immunotherapy;Communication;Cyclin D1;Data;Data Science;Dedications;design;Development;Disabled Persons;Discipline;Endothelium;Epithelial-Stromal Communication;Eragrostis;Faculty;Fostering;Genetically Engineered Mouse;Goals;Grant;Head and Neck Cancer;head and neck cancer patient;Head and Neck Squamous Cell Carcinoma;Head and neck structure;Human;Human Papillomavirus;humanized mouse;Immune;Immune Evasion;Immunocompetent;Immunosuppression;Immunotherapy;improved;improved outcome;in situ vaccination;in vitro Model;in vivo;Infiltration;inhibitor;innovation;Investigational Therapies;Lead;Malignant neoplasm of salivary gland;Malignant neoplasm of thyroid;Modeling;Molecular;monocyte;Morbidity - disease rate;mortality;Mus;novel;novel therapeutic intervention;Oncogenic;optimal treatments;Organ;palliation;participant enrollment;Pathogenesis;Pathology;patient derived xenograft model;Patients;Pharmaceutical Preparations;pharmacologic;Phase;phase I trial;Postdoctoral Fellow;pre-clinical;predictive marker;prognostic;Prognostic Marker;prognostic significance;programmed cell death ligand 1;programs;Proteins;Quality of life;Radiation therapy;recruit;Recurrence;Regimen;Regulatory T-Lymphocyte;Reproduction spores;Research;research and development;research clinical testing;Research Personnel;Research Project Grants;Resistance;Sampling;Signal Transduction;synergism;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Therapeutically Targetable;therapy development;Tissues;Tobacco;Transforming Growth Factor beta;Translating;translational cancer research;Translational Research;Translations;Treatment Efficacy;tumor;tumor microenvironment;Tumor-associated macrophages;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Vascular Endothelial Cell

PROJECT_TITLE: Colorado Head and Neck Cancer SPORE


NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Rare Diseases

PHR: NARRATIVE, Administrative Core The Administrative Core of the Colorado Head and Neck Cancer (HNC) SPORE will provide the operational administration to ensure the success of our SPORE as a whole. The benchmark of our success is to translate innovative research into clinical interventions for HNC patients.

PI_NAMEs: JIMENO, ANTONIO  (contact)

PROJECT_TERMS: Academia;Acceleration;Adherence;Advocate;anti-cancer research;Award;Awareness;Benchmarking;Cancer Research Project;career;Clinic;Clinical;Clinical Trials;Collaborations;Colorado;Communication;Communities;community engagement;Community Outreach;data sharing;Development;Discipline;Ensure;Evaluation;Goals;Guidelines;Head and Neck Cancer;head and neck cancer patient;Human Resources;Industrialization;Industry;innovation;Institution;Institutional Policy;Intellectual Property;interdisciplinary approach;Intervention;Leadership;lectures;meetings;member;Oncology Group;Organ;organizational structure;Outcomes Research;Pathology;Patients;Policies;programs;Progress Reports;Publications;Reproduction spores;Research;Research Personnel;Resources;Schedule;Scientist;Services;Site;Southwest Oncology Group;success;symposium;Tissues;Translating;Translational Research;United States National Institutes of Health;Visit;Work;Writing

PROJECT_TITLE: Colorado HNC SPORE Administrative Core


PHR: NARRATIVE The Evelyn F. and William L. McKnight Vision Research Center (MVRC) coordinates all aspects of the research mission of the Bascom Palmer Eye Institute. The MVRC draws together all NIH- NEI funded eye and vision research investigators across the University of Miami with a strong institutional commitment to support the operation and development of state-of-the art core modules: 1) Biological Imaging (BI) module, 2) Experimental Models (EM) module, and 3) a new In Vivo Imaging (IVI) module. Shared core resources enhance and expand the capabilities of individual laboratories, foster new and interdisciplinary research and educational programs, promote research of early stage investigators and provide a vibrant environment to recruit new investigators.

PI_NAMEs: HACKAM, ABIGAIL S (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Applications Grants;arm;Award;Biological;career;catalyst;Center Core Grants;Collaborations;Core Facility;Development;Discipline;Education;Environment;experience;Experimental Designs;Experimental Models;Eye;Eye diseases;Faculty;Financial Support;Fostering;Funding;Goals;Grant;Image;in vivo imaging;Incentives;Individual;Industry;innovation;Institution;Interdisciplinary Education;Interdisciplinary Study;Knowledge;Laboratories;Mentors;Methodology;Mission;operation;post-doctoral training;Postdoctoral Fellow;programs;Publications;recruit;Research;Research Personnel;Resource Sharing;Resources;Students;Talents;Technology;United States National Institutes of Health;Universities;Vision;Vision research

PROJECT_TITLE: Miami Center for Vision Research


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

PROJECT_TERMS: Adherence;Advisory Committees;Biological;Budgets;Center Core Grants;Conflict (Psychology);Contract Services;Core Facility;Core Grant;Department chair;Equipment;Experimental Designs;Experimental Models;Funding;Grant;Image;in vivo imaging;Intervention;Maintenance;medical schools;member;Monitor;National Eye Institute;Occupational activity of managing finances;operation;Preparation;Productivity;Progress Reports;Qualifying;repaired;Research Personnel;Resolution;Schedule;Technology;Universities;Vision research;vision science;web site

PROJECT_TITLE: Admin Module


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Eye Disease and Disorders of Vision;Neurosciences

PI_NAMEs: PEREZ, VICTOR L (contact)

PROJECT_TERMS: Award;Basic Science;Biological;biomarker identification;Collaborations;Communities;Confocal Microscopy;Data;digital;Disease;efficacy testing;Equipment;expression vector;Faculty;Fostering;Gene Transduction Agent;Grant;Histologic;Image;imaging software;imaging system;Imaging Techniques;Individual;innovation;Laboratories;Ligands;member;metabolomics;neural;novel therapeutics;ocular imaging;Production;Protein Analysis;Proteomics;Publications;receptor;recruit;Reporting;Research;Research Personnel;Resources;retinal imaging;System;Technology;Three-Dimensional Imaging;Tissues;Training;Translational Research;ultra high resolution;Universities;Viral;Vision research

PROJECT_TITLE: Biological Imaging Module


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Data Science;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Rare Diseases

PHR: NARRATIVE, Data Science Core The Data Science Core is designed to increase the speed and efficiency of support and scientific input with which head and neck cancer research is translated from the lab to the clinic. Core personnel have extensive experience in design and analysis of translational studies. Integrating personnel within a Core to support all SPORE programs will maximize the available resources and scientific impact.

PI_NAMEs: GAO, DEXIANG  (contact)

PROJECT_TERMS: Animal Experiments;anti-cancer research;Area;Award;Basic Science;Bioinformatics;Bioinformatics Shared Resource;Biological Markers;Biometry;career;Categories;Cells;Clinic;Clinical Data;Clinical Research;Clinical Trials;Clinical Trials Design;Collaborations;Colorado;Communication;Community of Practice;Data Analyses;Data Collection;data management;data platform;Data Science;Data Science Core;database design;density;design;Development;Doctor of Philosophy;effectiveness research;electronic data capture system;Ensure;Epidemiologist;Evaluation;experience;Experimental Designs;experimental study;Extramural Activities;Faculty;Focus Groups;Formulation;Genetic;Genetic Transcription;Genomics;Grant;Head and Neck Cancer;Head and neck structure;Human Resources;Immunological Models;Immunotherapy;improved;In Vitro;in vivo;individual responsibility;Informatics;innovation;Investigation;Laboratories;large datasets;Lead;Leadership;Link;Malignant Neoplasms;Manuscripts;member;Methods;Mission;Multiomic Data;Mus;next generation;novel;Observational Study;Outcome;Paper;Pathology;Peer Review;Play;Population Study;pre-clinical research;preclinical study;predictive modeling;Predictive Value;Preparation;Process;prognostic value;programs;Proteins;Proteomics;Publishing;quality assurance;Radiation;Recording of previous events;Reporting;Reproduction spores;Research;Research Design;Research Methodology;Research Personnel;Research Support;Resources;response;Retrieval;ribosome profiling;Ribosomes;Role;Sample Size;Services;single cell mRNA sequencing;single-cell RNA sequencing;small molecule;software development;Speed;Statistical Models;Structure;T cell receptor repertoire sequencing;T-Lymphocyte;Techniques;Testing;The University of Colorado Cancer Center;Therapeutic;therapeutic target;tool;trafficking;Translating;Translation Process;Translational Research;translational study;Universities;whole genome

PROJECT_TITLE: Colorado HNC SPORE Data Sciences Core


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: NEW ORLEANS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Narrative Peptides that self-assemble into macromolecule-sized nanopores in membranes could be useful in many biotechnology applications. To optimize nanopore forming peptides, the interactions that stabilize them must be understood. Synergistic experimental and computational research will reveal new insights into nanopore self assembly.

PI_NAMEs: WIMLEY, WILLIAM C (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TITLE: Structure and Function of Direct Delivery Peptides

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Neurosciences

PI_NAMEs: IVANOV, DMITRY V (contact)

PROJECT_TERMS: Animal Experimentation;Animal Model;Award;Basic Science;Behavior assessment;Biological;Canis familiaris;Collaborations;Consult;Data;Diabetes Mellitus;Drug Delivery Systems;Electrophysiology (science);Equipment;experience;Experimental Models;Faculty;Family suidae;Felis catus;Fostering;Funding;gene therapy;Genotype;Glaucoma;Grant;Human Resources;IACUC;in vivo evaluation;Macular degeneration;Methods;Modification;Mus;nonhuman primate;novel;nutrition;Operative Surgical Procedures;Optic Nerve Injuries;Oryctolagus cuniculus;Postdoctoral Fellow;Procedures;Protocols documentation;Publications;Rattus;Reporting;Research;Research Personnel;research study;Resources;Retinal Diseases;retinal ischemia;Rodent;Scientist;Services;Smoking;Testing;Tissues;Training;Translational Research;Vision;Vision research;Writing

PROJECT_TITLE: Experimental Models


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision

PI_NAMEs: RUGGERI, MARCO  (contact)

PROJECT_TERMS: Address;Algorithms;analytical tool;animal imaging;Animal Model;Applications Grants;Area;Award;Basic Science;Charge;Choroid;Clinical Sciences;Collaborations;cost;Custom;Data;Dedications;Development;Engineering;Ensure;Equipment;Eye;Eye diseases;Faculty;Fee-for-Service Plans;Fees;Film;Funding;Goals;Grant;Human Resources;human subject;Image;Image Analysis;image processing;imaging capabilities;Imaging Device;imaging modality;imaging software;Imaging Techniques;in vivo imaging;Individual;innovation;instrument;instrumentation;investigator training;Laboratories;Leadership;lens;Letters;Maintenance;Measurement;mechanical properties;Microcirculation;Modification;multiple omics;novel;Nursing Faculty;Ophthalmology;Patients;Publications;Reporting;Research;Research Personnel;Research Project Grants;research study;Research Support;Resource Development;Resources;retinal imaging;Schedule;Scientist;Technical Expertise;Technology;Training;Translational Research;tumor;Universities;Vision research

PROJECT_TITLE: In Vivo Imaging Module


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Public Health Relevance Cataracts are one of the most common eye diseases and also a leading cause of blindness worldwide. Connexins play important roles in lens cell homeostasis, and mutations in connexin genes lead to human congenital cataracts. The proposed research activity will help in understanding how connexin channels mediate the transport of antioxidants and other important biological molecules and should make novel contributions to new ideas and strategies for drug discovery and development in the treatment of cataracts.

PI_NAMEs: JIANG, JEAN X (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: age related;Anabolism;Antibodies;Antioxidants;Binding;Biological;Blindness;Cataract;Cell Death Induction;Cell Differentiation process;Cells;Chick;congenital cataract;Connexin 43;Connexins;Crystalline Lens;Cytoprotection;Data;Development;Dominant-Negative Mutation;drug development;drug discovery;Environment;Epithelial Cells;Epithelium;Excretory function;expectation;extracellular;Eye diseases;Fiber;fiber cell;fluid flow;gap junction channel;Gap Junctions;Gene Deletion;Genes;Glutathione;Goals;Growth;Hemostatic function;Homeostasis;Human;In Situ;inhibiting antibody;innovation;intercellular communication;Intercellular Junctions;Knockout Mice;Lead;lens;lens cortex;Lens Diseases;Lens Fiber;mechanical load;Mechanical Stimulation;Mechanics;Mediating;Metabolic;Microcirculation;Modality;Modeling;Mus;mutant;Mutation;new therapeutic target;novel;novel therapeutic intervention;Nuclear;Nutrient;Organ;Outcome;Oxidation-Reduction;oxidative damage;Oxidative Stress;Oxidative Stress Induction;P2X-receptor;Pathway interactions;Peptides;Physiological;Pilot Projects;Play;Process;Proteins;public health relevance;Publishing;Purinoceptor;Receptor Signaling;Regulation;release factor;Research;Research Activity;response;Role;shear stress;Signal Transduction;small molecule;System;targeted treatment;Testing;transmission process;Ultraviolet Rays;wasting;Wild Type Mouse

PROJECT_TITLE: Intercellular Communication in the Eye Lens


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Prevention;Rare Diseases

PHR: NARRATIVE, BPC The Biospecimen/Pathology Core (BPC) is essential to the success of the Colorado Head and Neck Cancer SPORE. The BPC is a central service that obtains tissues and information from patients with head and neck cancer. The collected tissue and information is stored and processed so that researchers have the best possible materials and information for their projects. In addition, the BPC provides unique skills and expertise in pathology and analysis technology to be successful in the execution of their projects.

PI_NAMEs: LUCIA, M. SCOTT (contact)

PROJECT_TERMS: Archives;biobank;Biological;biological specimen archives;Biological Specimen Banks;Body Fluids;Cancer Center;cancer clinical trial;career development;Chemopreventive Agent;Classification;CLIA certified;Clinical;Clinical Trials;Collaborations;Colorado;Computer Assisted;Consent;Core Facility;Cytogenetics;Data;Data Analyses;Data Science Core;Databases;Dedications;design;Development;Diagnostic;Disease;Disease Progression;DNA;Drug or chemical Tissue Distribution;experience;Extramural Activities;Generations;Genetic;Goals;Guidelines;Head and Neck Cancer;Health Insurance Portability and Accountability Act;Histologic;Histology;Human;Human Resources;human tissue;Image;Image Analysis;Immune;Immunohistochemistry;Immunologic Monitoring;improved;Individual;Infrastructure;Institutional Review Boards;Knowledge;Laboratories;laser capture microdissection;Leadership;Link;Medical;member;Methodology;Molecular;Molecular Analysis;molecular pathology;Morphology;operation;organizational structure;Outcome;Participant;Pathologic;Pathologist;Pathology;patient derived xenograft model;Patients;Performance;Practice Guidelines;prevent;preventive intervention;Procedures;Process;Proteins;Protocols documentation;Publishing;Reproduction spores;Research;Research Design;Research Personnel;research study;Resource Sharing;Resources;RNA;Service provision;Services;skills;Solid;Specimen;Specimen Handling;Standardization;success;System;Techniques;Technology;Testing;The University of Colorado Cancer Center;Therapeutic;thyroid neoplasm;Time;tissue archive;tissue processing;tissue resource;Tissue Sample;Tissues;tool;Translating;Translational Research;treatment response;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Colorado HNC SPORE Biospecimen/Pathology Core


ADMINISTERING_IC: HD

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Heart Disease - Coronary Heart Disease;Lung;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: San Francisco

ORG_NAME: OMNIOX, INC.

PHR: PROJECT NARRATIVE Omniox is developing a novel oxygen carrier protein, OMX, to preserve heart function during open-heart surgery that requires cardiopulmonary bypass (CPB). Approximately 10,000 children in the US are born every year with congenital heart defects that necessitate urgent open-heart surgery with CPB to correct the defect. However, while the patient is on CPB, the heart and other major organs are exposed to a lack of oxygen (hypoxia). The hypoxic environment drives a vicious cycle in which the heart tissue is damaged, negatively altering blood flow and reducing oxygen levels, and depriving all organ systems even further of oxygen. This cycle can result in a spectrum of post-operative complications, including reduced heart function, long-term neurological deficits, and kidney failure. This SBIR Phase IIB project will focus on testing OMX during bypass surgery in a clinically-relevant large animal model of congenital heart defect to validate OMX as a therapeutic to preserve heart and peripheral organ function in neonates requiring corrective heart surgery.

PI_NAMEs: FINEMAN, JEFFREY R;MALTEPE, EMIN ;WINGER, JONATHAN A (contact)

PROGRAM_OFFICER_NAME: PILEGGI, ANTONELLO

PROJECT_TERMS: Acute;Address;Advanced Development;analytical method;Animal Model;antagonist;Aorta;Asphyxia Neonatorum;Award;Biological Response Modifier Therapy;Blood flow;Body System;Bypass;California;cardiac repair;Cardiac Surgery procedures;Cardioplegic Solutions;Cardiopulmonary;Cardiopulmonary Bypass;Carrier Proteins;Carrying Capacities;Cerebrum;CHD1 gene;Child;Child health care;Childhood;Clinical;clinically relevant;Closure by clamp;congenital heart abnormality;Congenital Heart Defects;Contracts;Data;Defect;deprivation;design;Development;Disease;disease model;Dose;Endothelin;Environment;experience;Exposure to;Formulation;Free Radicals;Functional disorder;Good Manufacturing Process;Heart;heart defect;heart function;heart preservation;hemodynamics;Hemorrhagic Shock;Hepatic;Human;hypoperfusion;Hypoxia;hypoxic ischemic injury;improved;Induced Heart Arrest;Infant;inhaled nitric oxide;Ischemia;Kidney;Kidney Failure;lamb model;Lead;Left;Liver;Lung;manufacturing organization;manufacturing process;Medical;Modeling;Morbidity - disease rate;Myocardial;Myocardial Ischemia;Neonatal;neonatal care;neonatal patient;neonatal pulmonary hypertension;neonate;Neurologic Deficit;Newborn Infant;Nitric Oxide;novel;Operative Surgical Procedures;Organ;organ injury;Organ Preservation;Oxygen;Pamphlets;Pathology;Patients;pediatric patients;Performance;Perioperative;Peripheral;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;Phase Ia/Ib Clinical Trial;Postoperative Complications;Postoperative Period;preclinical study;preservation;Process;Production;protective effect;Proteins;Regimen;Research Personnel;Safety;San Francisco;Shunt Device;Small Business Innovation Research Grant;stem;Techniques;Testing;Therapeutic;therapeutic candidate;Tissues;translational approach;Treatment Efficacy;Universities;Variant

PROJECT_TITLE: Development of an oxygen delivery biotherapeutic for the preservation of myocardial function during pediatric cardiopulmonary bypass


NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Immunotherapy;Radiation Oncology;Rare Diseases

PHR: NARRATIVE, Project 1 In the treatment of head and neck cancer, radiation contributes to an immunologic phenotypic change and act to promote tumor growth and progression. Immunosuppressive cells including regulatory T cells (Tregs) and monocytes, which are precursors for tumor associated macrophages (TAMs), are recruited after radiation and represent a primary driver of resistance to therapy by generating an immune suppressive microenvironment. In this proposal, we examine how interactions between EphB4-ephrin-B2 at endothelial-immune cell interface in the context of radiation selectively enable a Treg- and TAM-rich microenvironment, switching it to a tumor- supportive phenotype.

PI_NAMEs: KARAM, SANA D (contact)

PROJECT_TERMS: Adhesions;Affect;angiogenesis;anti-tumor immune response;Autoimmune;Beds;Biological Assay;biomarker identification;Blood specimen;Blood Vessels;cancer cell;Cell Communication;cell motility;Cell Physiology;Cell Proliferation;Cell Survival;Cells;chemoradiation;Clinical Trials;Coculture Techniques;Colorado;cytokine;Cytometry;Cytoplasmic Tail;Cytoskeleton;Data;Disease;effector T cell;Embryonic Development;Endothelial Cells;Endothelium;Environment;EphB4 Receptor;Ephrin-B2;Flow Cytometry;Genetic;Genetically Engineered Mouse;Goals;Head and Neck Cancer;head and neck cancer patient;Head and Neck Squamous Cell Carcinoma;high risk;Human;Image;Immune;Immune checkpoint inhibitor;Immune Evasion;Immune Targeting;Immunocompetent;Immunofluorescence Immunologic;Immunofluorescence Microscopy;immunological status;Immunologics;immunoregulation;Immunosuppression;Immunotherapeutic agent;immunotherapy trials;Implant;In Vitro;in vivo;Infiltration;inhibitor;Intervention;intravital microscopy;knock-down;L-Selectin;Ligands;Macrophage;Macrophage Activation;Malignant Neoplasms;Mediating;Mediator;Methods;migration;Molecular;Molecular Target;monocyte;Motility;neoplastic cell;novel;Outcome;Participant;participant enrollment;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;Phosphorylation;Play;Population;potential biomarker;pre-clinical;Pre-Clinical Model;predictive marker;Process;Proto-Oncogene Proteins c-akt;Publishing;Radiation;radiation response;Radiation therapy;radiological imaging;receptor;Receptor Protein-Tyrosine Kinases;recruit;Regulatory T-Lymphocyte;Research;Resistance;response;response biomarker;Role;Sampling;side effect;Signal Transduction;Smoking History;Specimen;STAT3 gene;Stress Fibers;System;T cell response;Target Populations;Testing;therapeutic target;therapy resistant;Tissues;trafficking;transcriptome sequencing;treatment response;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-associated macrophages;tumor-immune system interactions;Tumor-infiltrating immune cells;Vascular Endothelial Cell

PROJECT_TITLE: Targeting EphB4-ephrinB2 to decrease immunosuppression in HNSCC


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE While fluorine-containing biomolecules play a key role in the design of new therapeutics and biomaterials, it remains difficult to predict how incorporation of fluorine will impact the stability and bioactivity of the modified biologic. The proposed research program will advance our understanding of how fluorinated compounds alter the folding, function and assembly of proteins and DNA to which they adsorb, and exploit the unusual physical properties that emerge to design new biopharmaceuticals and gene editing technologies.

PI_NAMEs: MEDINA, SCOTT HAMMOND (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TITLE: Understanding and controlling the cellular fate of fluorine-modified biologics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Doctors continue to struggle to diagnose lung cancer early when it is most curable. Lung cancer screening along with breakthroughs in blood tests and sophisticated computerized imaging may help solve this problem. We propose to enroll a diverse population with suspicious lung lesions in a trial to test these new technologies and also validate new ones for clinical use.

PI_NAMEs: DEPPEN, STEPHEN ;GROGAN, ERIC L (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: Academic Medical Centers;Aliquot;Benign;biobank;bioinformatics infrastructure;Biological Markers;biomarker validation;Biopsy;Blinded;Blood;Blood Tests;cancer biomarkers;cancer diagnosis;Cancer Patient;cancer risk;candidate validation;Categories;Chest;Classification;Clinical;clinical biomarkers;clinical implementation;clinical practice;clinical trial implementation;cohort;Collection;Communication;Communities;computerized;Consent;convolutional neural network;Data;deep learning;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic biomarker;Disease;Early Detection Research Network;Early Diagnosis;Enrollment;Epithelium;Evaluation;Funding;Goals;Histoplasmosis;Image;imaging biomarker;implementation trial;improved;industry partner;innovation;Lung;lung cancer screening;lung lesion;Lung nodule;Malignant neoplasm of lung;Malignant Neoplasms;medical schools;Modeling;mortality;new technology;Nodule;Outcome;patient screening;Patients;Phase;Pilot Projects;Play;Population;population health;Population Heterogeneity;Procedures;prospective;radiomics;randomized, clinical trials;recruit;Research Design;Resources;Risk;Risk Assessment;Risk Estimate;Role;sample collection;Sample Size;screening;Site;Specimen;support network;Testing;Time;Translating;United States;Universities;Validation;Washington;X-Ray Computed Tomography

PROJECT_TITLE: Clinical Utility of a Combined Biomarker Approach to Diagnose Lung Cancer


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Contraception/Reproduction;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Pregnancy;Women's Health Research

ORG_CITY: DALLAS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE After a woman has had a cesarean delivery, if the placenta implants on the surgical scar in a subsequent pregnancy, there is a risk for invasion, referred to as placenta accreta spectrum (PAS); depending on its severity, a cesarean hysterectomy may be required with significant morbidity. Imaging techniques such as magnetic resonance (MR) imaging have shown promise in defining characteristics that alert the obstetrician to the severity of PAS. We will explore the vascularity and tissue characteristics of the placenta with MRI and identify quantitative predictive markers of disease severity and hope to better understand the pathophysiology of placenta accreta spectrum.

PI_NAMEs: DO, QUYEN NGOC (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Abnormal placentation;Advisory Committees;Affect;Anatomy;arterial spin labeling;automated algorithm;Biology;Blood Vessels;career;career development;Cellularity;Cesarean section;Characteristics;Chemistry;Cicatrix;Clinical;Counseling;Data;Data Analyses;Data Set;deep learning;deep learning algorithm;Development;Development Plans;Diagnosis;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Exhibits;experience;fetal;First Pregnancy Trimester;Functional disorder;Future;Gestational Age;Goals;Hemorrhage;Heterogeneity;high risk;High Risk Woman;High-Risk Pregnancy;Human;Hysterectomy;Image;Image Analysis;imaging modality;Imaging Techniques;Implant;implantation;improved;interest;intrapartum;Invaded;Knowledge;Leadership;Life;Magnetic Resonance;Magnetic Resonance Imaging;Manuals;Maps;maternal morbidity;Maternal Mortality;Measurement;Measures;Mentorship;Modeling;Monitor;Morbidity - disease rate;Motion;multidisciplinary;Nature;Noise;novel;Operative Surgical Procedures;Outcome;Pathologic;Patients;Pattern;Perfusion;Perinatal;Physics;Physiological;Physiology;Pilot Projects;Placenta;Placenta Accreta;Positioning Attribute;predictive marker;predictive modeling;Pregnancy;prospective;Protocols documentation;radiomics;Recording of previous events;recruit;Reproducibility;Research;Research Design;Research Personnel;Resolution;Respiration;Risk;Risk Factors;Risk Marker;Severities;Severity of illness;skills;soft tissue;Statistical Data Interpretation;surgery outcome;T2 weighted imaging;Technical Expertise;Testing;Texture;Third Pregnancy Trimester;Tissues;tool;Training;ultrasound;Uterus;Visualization;Woman;Work

PROJECT_TITLE: Quantitative magnetic resonance imaging and automated textural radiomics for assessment of human placenta accreta spectrum

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Obstetrics and Maternal-Fetal Biology Study Section[CHHD-B]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: LOUISVILLE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: PROJECT NARRATIVE The proposed research will investigate brain circuits involved in active vision (circuits that link visual motion perception and gaze shifts). This research should provide information relevant to the treatment of disorders in which visual motion processing is compromised, such as dyslexia and schizophrenia and may provide insight into the use of eye tracking as a tool for medical diagnoses and/or eye movement disorders such as nystagmus, strabismus, and amblyopia.

PI_NAMEs: BICKFORD, MARTHA E (contact);BORGHUIS, BART GERARD;MCGEE, AARON W

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: active vision;Address;Affect;Amblyopia;Animals;Area;area striata;awake;Behavior;Behavioral;Brain;Butyric Acids;calcium indicator;Calcium Signaling;Cell Nucleus;cell type;Cells;Classification;Complex;Darkness;Depth Perception;Diagnosis;Disease;Disinhibition;Dorsal;Dyslexia;Electron Microscopy;extracellular;Eye Movements;Felis catus;Fluorescence;ganglion cell;gaze;Genetic;Glutamates;Image;In Vitro;in vivo;Injections;insight;Interneurons;Knowledge;Label;Lasers;Lateral Dorsal Nucleus;Lateral Geniculate Body;Light;Link;Mammals;Mediating;Medical;Methods;Miosis disorder;Modeling;monocular;Morphology;Motion;Motion Perception;Motor;Movement;Mus;Neurons;Neurotransmitters;novel;Ocular Motility Disorders;optogenetics;Parvalbumins;Pathologic Nystagmus;Pathway interactions;Pattern;Perception;Play;Population;Property;Pulvinar structure;rabies viral tracing;receptive field;Research;Research Personnel;response;Retina;Retinal Ganglion Cells;retinogeniculate;Role;Running;Saccades;Schizophrenia;Sensory;Shapes;Signal Transduction;Source;Speed;Strabismus;Synapses;Techniques;Testing;Thalamic structure;tool;Transgenic Organisms;transmission process;two-photon;Viral;Viral Vector;Vision;Visual;Visual Motion;visual stimulus;visual tracking;Whole-Cell Recordings

PROJECT_TITLE: The Influence of the Pretectum on the Visual Thalamus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-U(02)M]


NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Immunotherapy;Infectious Diseases;Orphan Drug;Radiation Oncology;Rare Diseases

PHR: NARRATIVE, Project 2 This project aims to bring therapeutic intervention to patients with locally recurrent head and neck cancer. We will employ locally advanced mouse models and patient-derived xenografts for experimental therapeutics in immune competent and compromised conditions, perform mechanistic analyses, and initiate a Phase Ib clinical trial. We aim to bring a therapeutic intervention to simultaneously enhance immunotherapy and reduce RT resistance in head and neck cancer patients.

PI_NAMEs: WANG, XIAO-JING  (contact)

PROJECT_TERMS: Affect;Aftercare;Antibodies;antitumor effect;Attenuated;biomarker driven;Biopsy;Blood Cells;Cancer Biology;candidate validation;Catchment Area;CD8B1 gene;Cell Death;Cell Death Induction;cell killing;Cells;Cessation of life;Clinical;Colorado;DNA;DNA Damage;DNA Repair;Epithelial Cells;Epithelium;FDA approved;Fibrosis;Future;Genes;Growth;Head and Neck Cancer;head and neck cancer patient;Head and Neck Squamous Cell Carcinoma;HPV positive;Human;Human Papillomavirus;Immune;immune activation;immune cell infiltrate;Immunocompetent;Immunosuppression;Immunosuppressive Agents;Immunotherapy;in situ cancer vaccine;in situ vaccination;Individual;Infiltration;inhibitor;Interferons;Investigational Therapies;ITGAM gene;Mediating;Medical Oncology;Metastatic Neoplasm to the Lung;Modeling;Molecular;molecular marker;mouse model;Mus;Mutant Strains Mice;Myeloid Cells;neoantigens;Neoplasm Metastasis;neoplastic cell;Nitroquinolines;novel;Nude Mice;Oral;oral HPV-positive head and neck cancers;oral mucositis;Oral mucous membrane structure;Outcome;Oxides;Pathway interactions;patient derived xenograft model;Patient Selection;Patients;Phase Ib Clinical Trial;Phase Ib Trial;phase II trial;Prediction of Response to Therapy;predictive marker;Prognosis;programmed cell death ligand 1;programmed cell death protein 1;Radiation;radiation effect;Radiation Oncology;radiation response;Radiation therapy;recruit;Recurrence;Regimen;Relapse;Reporting;Resistance;response;Safety;Sampling;Science;Serum;Signal Transduction;small molecule;Specimen;Systemic Therapy;T cell receptor repertoire sequencing;T-Cell Receptor;T-Lymphocyte;targeted agent;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapy outcome;Time;Tobacco;Toxic effect;Transforming Growth Factor beta;Transforming Growth Factors;Transplantation;treatment response;tumor;Tumor Antigens;Tumor Immunity;tumor immunology;tumor microenvironment;Tumor Promotion;Tumor-Infiltrating Lymphocytes;vaccine response

PROJECT_TITLE: Treating recurrent HNSCC with radiation and dual TGF-Beta/PD-L1.


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE Genome instability is a hallmark of cancer, and defects in the DNA damage response, which is required for the maintenance of genome stability are associated with cancer as well as human syndromes associated with reproductive, developmental and neurological defects. We address the functions of the Mre11 complex and RTEL1, both of which have been implicated in human chromosome instability syndromes associated with increased risk of malignancy, bone marrow failure, developmental abnormalities. The experiments described examine the roles of these proteins in the DNA damage response, and have the potential to provide insights regarding the mechanisms underlying human disease including cancer and immune deficiency.

PI_NAMEs: PETRINI, JOHN HJ (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Address;Affect;Animal Model;Area;ataxia telangiectasia mutated protein;ATM activation;ATM function;Biochemistry;Bone marrow failure;cancer genomics;Chromosomal Instability;Complex;Defect;Development;DNA;DNA biosynthesis;DNA Damage;DNA Repair;DNA replication fork;Eukaryota;experimental study;Genetic Screening;Genetic Transcription;Genome Stability;genomic data;Genomic Instability;Goals;Health;helicase;Human;Human Chromosomes;human disease;immunodeficiency;insight;Laboratories;Maintenance;Malignant Neoplasms;Mining;Modeling;mouse genetics;Mus;Mutation;Neurologic;Process;Proteins;Recurrent tumor;repair function;replication stress;reproductive;Resources;response;Risk;Role;Signal Transduction;structural biology;Syndrome;telomere;Untranslated RNA;Work;yeast genetics;Yeasts

PROJECT_TITLE: DNA Damage & DNA Replication: a Complex Relationship

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Emergency Care;Health Services;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Prevention;Unintentional Childhood Injury

PHR: PROJECT NARRATIVE Pediatric traumatic injury (i.e., injury of sudden onset and severity requiring immediate attention) is the leading cause of death and morbidity among US adolescents and are associated with mental health and health risk outcomes, including posttraumatic stress and depression (affecting between 19-42%), deficits in physical recovery, social functioning and quality of life, which if unaddressed, may contribute to increased use of health care services. We have partnered with three accredited Level I and II pediatric trauma centers and propose a multi-site hybrid 1 effectiveness-implementation trial with 300 adolescent (ages 12-17) traumatic injury patients to assess the extent to which the Trauma Resilience and Recovery Program (TRRP), a scalable and sustainable, technology-enhanced, multidisciplinary stepped model of care, promotes improvement in quality of life and emotional recovery and gather preliminary data on the potential for TRRP to be implemented in other Level I trauma centers. Directly in line with NICHD’s Pediatric Trauma and Critical Illness Research and Training (PTCIB) Strategic Research and Training agenda, this study will provide valuable data on the efficacy, preliminary effectiveness and potential for implementation of an innovative, cost-effective, sustainable technology-enhanced intervention designed to address the unique needs of adolescent injury patients and mitigate short- and long-term impact of injury on mental health, quality of life, and overall well-being.

PI_NAMEs: DAVIDSON, TATIANA MARGARITA (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: acceptability and feasibility;Accreditation;acute care;Address;Admission activity;Adolescent;adolescent patient;Adoption;Adult;Affect;Age;American College of Surgeons;Attention;automated text message;barrier to care;behavioral outcome;Caring;Cause of Death;Child;Childhood;Childhood Injury;cost effective;Critical Illness;Data;Dissemination and Implementation;Early Intervention;Education;Effectiveness;effectiveness/implementation trial;Emotional;Enhancement Technology;Evaluation;evidence base;experience;Family;follow up assessment;functional outcomes;Future;Guidelines;Health;health care service utilization;Health Services Accessibility;Hospitalization;Hospitals;Human Resources;Hybrids;implementation facilitators;implementation process;Improve Access;improved;informant;Infrastructure;Injury;innovation;Intervention;Interview;Medical Care Costs;Mental Depression;Mental Health;Mental Health Services;Modeling;Morbidity - disease rate;multidisciplinary;National Institute of Child Health and Human Development;Outcome;Participant;Patients;pediatric trauma;Personal Satisfaction;Persons;Policies;post-traumatic stress;Post-Traumatic Stress Disorders;Prevalence;programs;psychologic;psychosocial;Quality of life;Randomized;Randomized, Controlled Trials;Reaction;Recommendation;Recovery;recruit;Research;resilience;Resources;Risk;Risk Reduction;satisfaction;screening guidelines;service programs;Services;Severities;Site;Social Functioning;societal costs;Structure;Suggestion;Survivors;sustainable resource;Symptoms;System;telehealth;Telephone;therapy design;Training;Trauma;trauma centers;Traumatic injury;treatment as usual;Youth

PROJECT_TITLE: Evaluation of Trauma Center-Based, Technology-Enhanced Stepped Care Intervention for Adolescent Traumatic Injury Survivors

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE Expanding knowledge on the best ways to prevent and treat aging-related functional decline and on the onset of chronic disease, including dementia, requires quality research performed by competent and experienced research scientists. This training program will provide resources for postdoctoral trainees to develop a research career through practical experience with an experienced mentor and through additional formal education. Scholars will emerge from the program with a scientific understanding of the pathways leading to aging-related disability, and with a specific set of technical research skills, enhancing the overall development of future research leaders in aging and dementia-related research.

PI_NAMEs: KRITCHEVSKY, STEPHEN B. (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Aging;Alzheimer's disease related dementia;Training

PROJECT_TITLE: Translational Training in Aging and Alzheimer’s Disease Related Disorders


NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Immunotherapy;Orphan Drug;Radiation Oncology;Rare Diseases

PHR: NARRATIVE. Major limitations in understanding the cancer-host interaction and in finding drugs that will help us stop cancer progression include either simply culturing cancer cells on plastic dishes or injecting cells on mice that have no human immunity. To study a new drug (SVC112) that inhibits production of proteins vital to cancer cells while addressing these limitations, we are proposing to use assays that include active human immune cells and a humanized mouse model, which can actually mimic what happens in a patient more closely, and will make the testing of SVC112 more robust. Our goal is to determine if modulating protein synthesis with SVC112 will enhance the efficacy of radiation and immune therapy, the two main modalities in use in early and late head and neck cancers.

PI_NAMEs: JIMENO, ANTONIO  (contact)

PROJECT_TERMS: Address;Affect;Biological Assay;Biological Markers;cancer cell;cancer infiltrating T cells;Cell Communication;Cell Cycle;Cell Line;Cell model;Cells;Clinical Trials;Colorado;Companions;Complex;Cyclin D1;Data;Disease;Dose;Drug Kinetics;Drug resistance;efficacy testing;Evaluation;Failure;FDA approved;fitness;FRAP1 gene;gene product;Genes;Goals;Growth;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Head and neck structure;Home;HPV positive;HPV-negative head and neck cancer;Human;Human Papillomavirus;humanized mouse;Hypoxia;Immune;Immune Evasion;Immune Targeting;Immunity;immunodeficiency;Immunologic Surveillance;Immunotherapy;In Vitro;in vivo;in vivo Model;inhibitor;Internal Ribosome Entry Site;Invaded;Ligands;Malignant Neoplasms;Measures;Mediating;Messenger RNA;Minority;Modality;Modeling;Molecular Target;mouse model;Mus;Mutation;novel therapeutics;Oncogenic;Oncoproteins;Outcome;Papillomavirus Transforming Protein E6;Pathway interactions;patient derived xenograft model;Patients;pembrolizumab;Pharmaceutical Preparations;pharmacologic;PIK3CG gene;predictive marker;Predictive Value of Tests;Predisposition;Production;Prognosis;programmed cell death ligand 1;programmed cell death protein 1;Property;Protein Biosynthesis;protein expression;Protein Synthesis Inhibition;Proteins;Proteome;Proteomics;Proto-Oncogene Proteins c-myc;Radiation therapy;Relapse;Reporting;Resistance;Rest;ribosome profiling;Ribosomes;Sampling;Signal Transduction;small molecule;stemness;Stress;synergism;T-Lymphocyte;Testing;Therapeutic;Therapeutic Index;Tissue Banks;Tissues;tool;Toxic effect;transcription factor;Translations;Treatment Efficacy;Treatment Failure;tumor;Tumor Bank;tumor growth;tumor microenvironment;tumor progression;Tumor-infiltrating immune cells;Work

PROJECT_TITLE: Targeting eEF2 with the protein translation elongation inhibitor SVC112 in head and neck squamous cancer


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Rare Diseases;Wound Healing and Care

ORG_DEPT: DERMATOLOGY

PHR: Project Narrative These studies are designed to generate new insights into the basic cellular mechanisms that regulate cell-cell interactions, and to expose new therapeutic targets for the treatment of pemphigus and other skin diseases characterized by skin fragility.

PI_NAMEs: KOWALCZYK, ANDREW P. (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: 3-Dimensional;Adhesions;Adhesives;Antibodies;Architecture;Atomic Force Microscopy;Autoantibodies;Autoimmune;B cell therapy;Binding;Biology;Bulla;Cadherins;Cell Adhesion;Cell Communication;Cell-Cell Adhesion;Cells;cellular imaging;Clathrin;Communicable Diseases;Complex;Cryoelectron Microscopy;Cultured Cells;design;desmoglein III;Desmosomes;Development;Disease;Disease Progression;disorder risk;Endocytosis;Endoplasmic Reticulum;endoplasmic reticulum stress;Epidermis;Epithelium;Epitope Mapping;experimental study;Exposure to;Foundations;Homeostasis;imaging approach;Imaging technology;Immunoglobulin G;Immunosuppressive Agents;improved;Infectious Skin Diseases;Inflammatory Response;Inherited;insight;Intercellular Junctions;keratinocyte;Life;live cell imaging;MAP Kinase Gene;Mediating;Membrane Microdomains;Modeling;Molecular;molecular dynamics;Monoclonal Antibodies;Mucous Membrane;new therapeutic target;novel;novel therapeutics;optical imaging;Outcome Study;p38 Mitogen Activated Protein Kinase;particle;Pathway interactions;patient safety;Patients;Pemphigus;Pemphigus Vulgaris;Peripheral;Play;Protein Dynamics;Proteins;Rare Diseases;Regulation;Resolution;response;Risk;Role;Series;Shapes;Signal Induction;Signal Pathway;Signal Transduction;Skin;skin barrier;skin disorder;Sorting;Stress;Testing;therapeutic target;Tissues;Transcript;Tubular formation;Vesicle

PROJECT_TITLE: Keratinocyte adhesion and signaling in the skin blistering disease pemphigus vulgaris


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Immunotherapy;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: Project Narrative Immunotherapy is an exciting new frontier of anti-cancer therapy, yet response rates have been modest in many solid tumor types including high grade serous carcinoma (HGSC). We postulate that the inhibition of the non-homologous end joining pathway of DNA damage repair with agents including aurora kinase inhibitors triggers type I interferon signaling to sensitize cold HGSC to immune checkpoint receptor blockade. This combinatorial treatment approach has the potential for direct translation to clinical trials with the goal of improving patient outcomes.

PI_NAMEs: MCLEAN, KAREN  (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Address;anti-tumor immune response;Apoptotic;aurora kinase;aurora kinase A;Biological Models;BRCA mutations;BRCA1 gene;Cancer Etiology;cancer therapy;cancer type;Carcinoma;Cell Culture Techniques;Cell Death;Cell Line;Cell Physiology;Cells;checkpoint receptors;Chemoresistance;clinical development;Clinical Trials;combinatorial;Cytotoxic Chemotherapy;Data;Defect;DNA;DNA Damage;DNA Repair;Down-Regulation;Epithelial ovarian cancer;experimental study;frontier;Genetic;Genetically Engineered Mouse;Genotype;Germ Lines;Goals;homologous recombination;homologous recombination deficiency;Human;Immune;immune activation;immune cell infiltrate;immune checkpoint;immune checkpoint blockade;Immune response;Immunocompetent;immunogenicity;Immunotherapy;improved;in vivo;inhibitor;inhibitor therapy;insight;Interferon Type I;kinase inhibitor;Knock-out;Knowledge;Link;Malignant Epithelial Cell;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;Mediating;Methods;Mouse Cell Line;mouse model;mutational status;neoplastic cell;Nonhomologous DNA End Joining;novel;novel therapeutic intervention;Outcome;Ovary;overexpression;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Patients;Peritoneum;Phosphotransferases;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Pre-Clinical Model;preclinical development;programmed cell death ligand 1;Proteins;Recurrent disease;Research;response;Role;Sampling;Serous;Signal Transduction;Signaling Protein;Solid;Solid Neoplasm;Specificity;Survival Rate;Testing;TP53 gene;transcriptome sequencing;Translations;treatment response;treatment strategy;tumor;Tumor Immunity;type I interferon receptor;United States;Women's mortality;Work

PROJECT_TITLE: Sensitizing high grade serous cancers to immunotherapy through the induction of DNA damage

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Rare Diseases

PHR: NARRATIVE, Developmental Research Program The premise of the Developmental Research Program within the Colorado HNC SPORE application is that innovative, high-risk research from existing head and neck cancer researchers, and an influx of research from investigators with expertise outside of, but that can be applied to head and neck cancer, will catalyze significant advances in the understanding and treatment of HNC.

PI_NAMEs: REYLAND, MARY ELAINE (contact)

PROJECT_TERMS: anti-cancer research;Applications Grants;Basic Science;Budgets;career;Clinic;Clinical;Collaborations;Colorado;Communities;Data;Development;Ensure;Evaluation;flexibility;Funding;Goals;Grant;Head and Neck Cancer;high risk;Hospitals;innovation;Institution;Intervention;Medical;meetings;Monitor;novel;Patient-Focused Outcomes;Pilot Projects;Population;Process;Program Research Project Grants;programs;Progress Reports;Qualifying;Research;Research Personnel;Resources;response;Scientist;success;Technology;tool;translational potential;Translational Research;translational research program;United States Department of Veterans Affairs;Universities

PROJECT_TITLE: Colorado HNC SPORE Developmental Research Program


NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Transplantation

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Glaucoma is a chronic optic nerve disease and the most common cause of irreversible blindness in the world. Though stem cell transplantation holds promise as a future treatment capable of restoring vision through optic nerve regeneration, translating this therapy to patients requires improved understanding of the factors that limit survival and integration of neurons into the visual system after intraocular transplantation. This mentored clinician-scientist training plan proposes to study in rigorous detail how human RGCs generated from stem cells survive and functionally integrate with the retina in multiple models of optic nerve degeneration, and tests methods for improving these outcomes on the path towards functional RGC replacement.

PI_NAMEs: JOHNSON, THOMAS VINCENT (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: 3-Dimensional;Address;Affect;Amacrine Cells;Anatomy;Astrocytes;Axon;axon guidance;axon regeneration;Bilateral;Blindness;Brain;Brain-Derived Neurotrophic Factor;Cadherins;career;career development;Caring;Cell Communication;Cell Death;Cell Differentiation process;Cell Line;Cell Nucleus;Cell Survival;Cell Transplantation;Cells;Chronic;Clinic;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Communication;Complex;Cues;Dendrites;Development;Disease;Electrophysiology (science);Engineering;Engraftment;Ensure;Environment;Experimental Models;experimental study;Extracellular Matrix;Eye;Funding;Future;ganglion cell;Ganglion Cell Layer;Gene Expression;Generations;Genetic Engineering;Glaucoma;Gliosis;Goals;Graft Survival;Growth;Human;Human Cell Line;human disease;Human Engineering;human stem cell-derived;human stem cells;improved;improved outcome;in vivo;in vivo evaluation;innovation;Integrins;Laboratories;Laboratory Research;Mammals;Mediating;Medical;Membrane;Mentors;Mentorship;method development;Methods;Microscopy;migration;Modeling;Molecular;Molecular Biology;Molecular Target;multiphoton microscopy;Mus;Natural regeneration;Nerve Crush;nerve damage;Nerve Degeneration;Nerve Fibers;neural;Neurites;Neurodegenerative Disorders;Neuroglia;neuroinflammation;neuronal cell body;neuronal patterning;neuronal survival;Neurons;neuroprotection;Neurosciences;novel;Ocular Hypertension;Operative Surgical Procedures;Ophthalmology;Optic Nerve;optic nerve disorder;Optic Nerve Injuries;optic nerve regeneration;Outcome;Outcome Assessment;patch clamp;Pathway interactions;Patients;Persons;pharmacologic;Property;receptor;reconstruction;Regenerative research;repaired;Reporter;Repression;Research;Research Personnel;Retina;retina transplantation;retinal ganglion cell regeneration;Retinal Ganglion Cells;retinal neuron;Scientist;Secondary to;sight restoration;Signal Pathway;Signal Repression;Signal Transduction;Site;skills;Specialist;stem cell survival;stem cell therapy;Stem cell transplant;stem cells;Surface;Synapses;synaptogenesis;Techniques;Testing;Tissues;Training;Training Programs;Transgenic Organisms;Translating;Translational Research;Transplantation;Visual;Visual System;Work

PROJECT_TITLE: Transplantation of human stem cell-derived neurons for retinal ganglion cell replacement and optic nerve regeneration.


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Comparative Effectiveness Research;Data Science;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Atrial fibrillation (AF) is a major public health problem resulting in preventable strokes and increased incidence of heart failure and early cognitive decline. Preventive interventions such as AF screening have potential to improve outcomes but appear inefficient when applied indiscriminately. In this proposal, we will develop novel deep learning-based methods to estimate AF risk in an automated fashion using mobile single-lead electrocardiograms, develop a comprehensive simulation to quantify the comparative effectiveness of a risk- based approach to AF screening, and perform a pilot study to quantify the user acceptability of prospective AF risk estimation and quantify associations between estimated AF risk and true AF incidence.

PI_NAMEs: KHURSHID, SHAAN  (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Advisory Committees;Affect;Age;Alcohols;Anticoagulation;Arrhythmia;Atrial Fibrillation;Body Weight decreased;Calibration;Cardiac;Cardiology;Cardiomyopathies;cardiovascular disorder risk;career;career development;Circulation;Clinical;Clinical Data;Clinical effectiveness;Clinical Research;clinical risk;comparative effectiveness;Complex;Conflict (Psychology);cost effectiveness;Custom;Data;Data Science;Data Scientist;Data Set;Decision Analysis;Decision Modeling;deep learning;deep learning model;design;Development;Diagnosis;Diagnostic tests;Discrimination;Disease;disorder risk;Early Diagnosis;Electrocardiogram;Electrophysiology (science);European;Exercise;experience;Fellowship;Future;General Hospitals;Goals;Guidelines;handheld mobile device;Health;health care settings;Healthcare;Heart failure;heart rhythm;Impaired cognition;implementation science;improved;improved outcome;Incidence;Individual;interest;Intervention;Intervention Studies;Lead;Learning;Learning Skill;Machine Learning;machine learning model;Manuscripts;Mass Screening;Massachusetts;medical schools;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;model building;Modeling;models and simulation;Monitor;Morbidity - disease rate;multidisciplinary;novel;Oral;Outcome;Patients;Peer Review;Persons;Pilot Projects;population based;Positioning Attribute;predictive tools;preventive intervention;Preventive measure;Primary Care;primary care patient;Program Development;prospective;Public Health;Publishing;Research Personnel;Research Training;Residencies;Risk;Risk Estimate;Risk Factors;risk prediction;risk prediction model;Risk Reduction;Sampling;Science;screening;sex;simulation;skills;Stroke;Stroke prevention;Surveys;Testing;therapy design;tool;Training;trial comparing;United States;virtual;Work

PROJECT_TITLE: Electrocardiogram-based deep learning and decision analysis to improve atrial fibrillation risk estimation

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


PHR: NARRATIVE, Career Enhancement Program The Career Enhancement Program (CEP) will encourage promising candidates at the University of Colorado  Cancer Center to pursue translational research careers in head and neck cancer (HNC). The CEP will provide  these investigators with financial support, mentorship for scientific projects and career development, and  opportunities for collaboration. The long-term goal is to foster these individuals into successful independent  research careers and to incorporate them and their new ideas/projects into the Colorado HNC SPORE.

PI_NAMEs: NEMENOFF, RAPHAEL A. (contact)

PROJECT_TERMS: Animals;anti-cancer research;Basic Science;Cancer Center;cancer clinical trial;career;career development;Clinic;Clinical Sciences;clinical translation;Collaborations;college;Colorado;Country;Dental Schools;Development;Discipline;Discipline of Nursing;Educational workshop;Environment;Faculty;Financial Support;Fostering;Funding;Goals;Grant;Head and Neck Cancer;Human;Individual;Infrastructure;Institution;interdisciplinary collaboration;interest;Investigation;Malignant neoplasm of thyroid;Measures;Medical;medical schools;Medicine;member;Mentors;Mentorship;multidisciplinary;Oncology;Participant;Pharmacologic Substance;Pharmacy Schools;Population Sciences;Productivity;programs;Public Health Schools;Publications;Recommendation;recruit;Reproduction spores;Request for Applications;Research;Research Personnel;Research Project Grants;Review Committee;Salivary Gland Neoplasms;Science;Squamous cell carcinoma;Structure;success;The University of Colorado Cancer Center;tool;Training;translational cancer research;translational impact;translational pipeline;Translational Research;translational scientist;Universities;Veterinary Medicine;Writing

PROJECT_TITLE: Colorado HNC SPORE Career Enhancement Program


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: PSYCHOLOGY

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative An understanding of visual processing is critical for treating brain-based visual impairment and for developing visual prosthetic devices. But we lack a theoretical framework for neural circuit computations in the visual cortex of the brain. Through the proposed research, we aim to provide such a theory, thereby providing a better understanding of the details of how visual cortex circuits operate, leading to better assessment, diagnosis, and treatment of disorders of visual perception and attention.

PI_NAMEs: HEEGER, DAVID J (contact);MARTINIANI, STEFANO

PROJECT_TERMS: Area;area striata;Attention;attentional modulation;Behavior;Behavioral;Biophysics;Brain;brain based;cell type;Cerebral cortex;Characteristics;Code;cognitive process;computerized tools;Data;Data Set;Dependence;Diagnosis;Discrimination;discrimination task;Exhibits;experimental analysis;Experimental Designs;experimental study;Goals;Link;Measures;Methodology;Modeling;neural;neural circuit;neural model;Neurons;neurophysiology;Noise;novel;Ocular Prosthesis;orientation selectivity;Performance;Population;predictive modeling;Property;Prosthesis;Psychophysics;Publishing;Recurrence;Research;Resources;response;Shapes;statistics;Stimulus;Sum;Synapses;System;Testing;theories;V1 neuron;Vision Disorders;Visual attention;Visual Cortex;visual discrimination;Visual impairment;Visual Perception;visual processing

PROJECT_TITLE: Recurrent Circuit Model of Neural Response Dynamics in V1

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]