NIH_SPENDING_CATS: Brain Disorders;Genetic Testing;Genetics;Human Genome;Neurosciences;Orphan Drug;Pediatric;Prevention;Rare Diseases

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE OTC and NAGS deficiency are very rare genetic diseases that cause the build-up of ammonia in the body, which can cause brain damage or death. DNA sequencing of the OTC and NAGS genes is used to diagnose patients, but often the test results are not clear because not all genetic changes cause disease. This proposal is relevant to public health because it will provide information that will help medical experts determine which genetic changes in the OTC and NAGS genes cause disease and require treatment.

PI_NAMEs: AH MEW, NICHOLAS  (contact);CALDOVIC, LJUBICA MORIZONO

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: 10 year old;accurate diagnosis;Address;Affect;aggregation database;Alleles;American;Ammonia;Archives;Attenuated;Basic Science;Biochemical;Brain Death;Brain Edema;Brain Injuries;Cessation of life;Child;Classification;Clinical;clinical center;Clinical Data;clinical diagnosis;clinical diagnostics;clinical phenotype;clinical practice;Clinical Research;Clinical Trials;Clinical Trials Design;clinically actionable;ClinVar;Coma;Computers;Counseling;Data;data anonymization;Data Set;data submission;database of Genotypes and Phenotypes;Databases;Defect;Deposition;design;Diagnosis;Diagnostic;Disease;DNA;DNA Sequence;DNA sequencing;Early Diagnosis;Early treatment;Elements;Eligibility Determination;Enzymes;Executive Dysfunction;exome sequencing;Family;Funding;Genes;genetic pedigree;Genetic Screening;genetic variant;Genomics;Genotype;Guidelines;Hospitals;Human Genetics;Hyperammonemia;improved;improved outcome;Inborn Errors of Metabolism;Individual;Intellectual functioning disability;Laboratories;Ligase;Link;Maps;Medical;Medical Genetics;medical schools;member;Metabolic Diseases;Metabolism;Molecular;molecular pathology;multiple datasets;Mutation;N acetyl glutamate synthetase deficiency;N acetyl L glutamate;Names;National Center for Advancing Translational Sciences;National Institute of Child Health and Human Development;Natural History;Neonatal Screening;Nervous System Trauma;Neuropsychology;neurotoxic;Only Child;Ornithine Carbamoyltransferase;Ornithine carbamoyltransferase deficiency;Participant;Pathogenicity;Patients;Pharmaceutical Preparations;phenotypic data;Population;prenatal;prevent;Privatization;public database;Public Health;Publications;Publishing;Rare Diseases;rare genetic disorder;reproductive;Research Priority;Risk;segregation;Site;Source;Standardization;Test Result;Testing;United States National Institutes of Health;Update;Urea;urea cycle;Urea cycle disorders;urea transporter;Variant;variant of unknown significance

PROJECT_TITLE: Oldies but Goodies: Rescuing confined OTC and NAGS genetic variant data from legacy databases and natural history studies

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


ADMINISTERING_IC: HD

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Disability Research;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: We will develop a new experimental strategy in mice that tests variants of uncertain significance found in patients with neurodevelopmental disability (NDD), focusing on genes that cause NDD by haploinsufficiency. We will demonstrate proof of principle for the NDD gene ANKRD17 by using i-GONAD in vivo gene-editing technology to introduce hemizygous and homozygous Ankrd17 variants in zygotes and then comparing the resultant fetal phenotypes to that of Ankrd17 knockout mice.

PI_NAMEs: WARMAN, MATTHEW L (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Adopted;Alleles;Amino Acids;Benign;Biochemical;Biological Assay;Blood Vessels;Cardiovascular system;Caring;Cells;Classification;Clinical Research;ClinVar;Clupeidae;Counseling;Data;Databases;design;Development;Diagnosis;Disease;Embryo;Etiology;Exhibits;experimental study;Family;fetal;Fetus;gene editing technology;gene-editing approach;Genes;Genetic Counseling;Genotype;Grant;Heart;Heterozygote;Histologic;Human;human disease;in utero;In Vitro;in vivo;in vivo evaluation;Individual;innovation;insertion/deletion mutation;Intellectual functioning disability;Journals;Knock-out;Knockout Mice;LGR5 gene;Link;loss of function;malformation;Medical;Methods;Missense Mutation;Mouse Strains;Mus;Mutate;Mutation;neurobehavioral test;Neurodevelopmental Disability;Orthologous Gene;Parents;Pathogenicity;Patient Care;Patients;Peer Review;Phenotype;phenotypic data;Physicians;postnatal;Pregnancy;proband;Proteins;public database;Publishing;Recommendation;Reporting;Reproducibility;Research Project Grants;Resolution;RNA Splicing;Scientist;Site;Standardization;Techniques;Termination of pregnancy;Testing;Translational Research;United States National Institutes of Health;Variant;variant of unknown significance;zygote

PROJECT_TITLE: In vivo assessment of variants of uncertain significance in the intellectual disability gene ANKRD17

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Diabetes is a metabolic disease that can also lead to extremely serious vascular (i.e., blood vessel) disease. This project will provide novel insights as to why patients with diabetes are susceptible to developing vascular disease and will fill important gaps in our understanding of mechanisms that connect metabolic dysregulation with impaired vascular function. We will also develop novel nanomedicine to target these mechanisms for treating diabetes-associated peripheral artery disease, which has very limited therapeutic options.

PI_NAMEs: CHEN, ZHEN BOUMAN (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Address;Adult;Automobile Driving;Award;Biology;Blood Vessels;Cell Physiology;Chromatin;Development;Diabetes Mellitus;diabetic;Disease;effective therapy;efficacy evaluation;Endothelial Cells;endothelial dysfunction;Endothelium;epigenetic memory;Epigenetic Process;epigenome;epitranscriptome;experience;Funding;gene therapy;Goals;high risk;Impairment;innovation;innovative technologies;insight;Knowledge;Mediating;Mediator;Medical;Memory;Metabolic;Metabolic Diseases;MicroRNAs;Mission;Modification;nanomedicine;nanoparticle;National Heart, Lung, and Blood Institute;novel;novel therapeutics;Pain;Patients;Peripheral arterial disease;Play;Population;Predisposition;Research;Research Personnel;restoration;RNA;Role;targeted treatment;Testing;Therapeutic;therapeutic target;Untranslated RNA;Vascular Diseases;vascular inflammation;Vascular regeneration;Vision

PROJECT_TITLE: RNA-mediated endotheliopathy in diabetic vasculopathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-L (O2)]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Herpesviruses are ubiquitous human pathogens and cause significant morbidity and mortality worldwide. Direct antivirals have been developed solely targeting viral thymidine kinase to impede viral genome replication and antivirals of new mode of action is desperately needed to overcome emerging drug-resistant variants. We propose to develop a new antiviral therapy targeting the immune evasion viral protein, UL37, to block protein deamidation and restore host immune defense.

PI_NAMEs: FENG, PINGHUI  (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: absorption;Acids;Acquired Immunodeficiency Syndrome;Active Sites;Acyclovir;Alzheimer's Disease;Alzheimer's disease related dementia;Anti-viral Agents;anti-viral efficacy;Anti-viral Therapy;Basic Science;Biochemical;Biological Assay;Biological Process;Cells;clinical application;Collaborations;combat;Complex;coping;cytokine;deamidation;Disease;drug candidate;Drug resistance;ds-DNA;Excretory function;experimental study;General Population;Genome;Glutamine;glutamine analog;Glycoproteins;Herpes Simplex Infections;Herpesviridae;Herpesviridae Infections;Herpesvirus 1;Human Herpesvirus 2;human pathogen;Immune;Immune Evasion;Immune response;Immune Targeting;Immunologics;improved;in vivo;Individual;Infection;inhibitor;Innate Immune Response;interest;Invaded;Investigation;Kidney;Lead;lead optimization;Libraries;Link;lytic replication;Mass Spectrum Analysis;Mediating;Metabolism;Microbe;molecular dynamics;Morbidity - disease rate;mortality;mouse model;Mus;Nerve Degeneration;novel;novel therapeutics;Nucleic Acids;nucleoside analog;Nucleosides;Organ;pathogen;Patients;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;Pilot Projects;prevent;Production;Property;Proteins;Reporting;Series;Simplexvirus;small molecule;Structural Biologist;Thymidine Kinase;tool;Toxic effect;Translating;Variant;Viral;Viral Drug Resistance;Viral Genome;Viral Physiology;Viral Proteins;Virus Replication;Work

PROJECT_TITLE: Targeting the UL37 deamidase to impede HSV-1 infection.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-B (81)]


ED_INST_TYPE: SCHOOLS OF MEDICINE

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE Aging is associated with the loss of resilience and reparative potential at the cellular level and is the most powerful risk factor for the development of cardiovascular disease. While most of the known risk factors for CV disease are susceptible to contemporary therapeutic or lifestyle interventions, there is no specific therapy that slows, prevents or reverses the impact of age on the cardiovascular system. We have assembled an integrated proposal and a multidisciplinary team to investigate systematically the pleiotropic effects of lifelong PAI-1 deficiency on cardiovascular aging. We anticipate that the studies proposed here will advance our understanding of the pivotal role of PAI-1 in aging-related cardiovascular morbidity, the molecular and epigenetic mechanisms that explain this relationship, and provide proof of principle that pharmacological inhibition of PAI-1 is a rational therapeutic approach in preventing aging-related cardiovascular disease in humans.

PI_NAMEs: VAUGHAN, DOUGLAS E (contact)

PROGRAM_OFFICER_NAME: REID, DIANE M

PROJECT_TERMS: Age;age effect;Aging;aging related;Alzheimer's Disease;American;Amish;Back;Biological Aging;Blood Vessels;Body System;Cardiovascular Diseases;cardiovascular fitness;Cardiovascular Pathology;Cardiovascular system;Cells;Communities;Coronary Arteriosclerosis;design;Development;Diabetes Mellitus;Disease susceptibility;Epigenetic Process;experimental study;Fasting;fatty liver disease;flexibility;Gene Proteins;Generations;Geography;Heart;Heterozygote;Human;human old age (65+);induced pluripotent stem cell;Insulin;Kidney;kindred;Laboratories;life span;lifestyle intervention;Link;loss of function;loss of function mutation;Molecular;Molecular Profiling;Morbidity - disease rate;multidisciplinary;multiple chronic conditions;Mus;Natural experiment;null mutation;Obesity;Obstructive Lung Diseases;Pathology;pharmacologic;Plasminogen;pleiotropism;Population;preservation;Prevalence;prevent;Privatization;protective effect;Proteins;Pulmonary Emphysema;reparative capacity;resilience;Risk Factors;Role;senescence;SERPINE1 gene;Skin;telomere;Testing;Therapeutic;Therapeutic Intervention;Translating;Variant

PROJECT_TITLE: Heterozygous SERPINE1 Deficiency Confers Durable Cardiovascular Fitness in Humans

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-I (O1)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Neurosciences;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE This project develops an advanced mouse model of chimeric antigen receptor (CAR) T cell cancer immunotherapy for malignant brain tumors, which has been challenging in the clinical setting because of limited ability of the CAR T cells to travel to the tumors and survive in the hostile microenvironment. We will use an immunocompetent transgenic mouse model to induce brain-intrinsic tumors via viral delivery of oncogenes into brain progenitor cells, and image the tumor growth and CAR T cell infiltration into the tumor using two-photon microscopy via a cranial window. The overarching goal of this work is to create a flexible, freely shared model that enables the study of molecular mechanisms of CAR T cell targeting against brain tumors.

PI_NAMEs: GUST, JULIANE  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Adult;Affect;Age;B-Lymphocytes;Back;Birds;Blood;Brain;Brain imaging;Brain Neoplasms;brain parenchyma;brain tumor imaging;cancer imaging;cancer immunotherapy;CAR T cell therapy;CD19 gene;Cell Communication;cell type;Cells;Central Nervous System Lymphoma;Cephalic;Cerebrospinal Fluid;Child;Childhood;chimeric antigen receptor;chimeric antigen receptor T cells;cisterna magna;Clinical;Clinical Trials;clinically relevant;cranium;Cues;Dose;Effector Cell;Environment;experimental study;extracellular;flexibility;Flow Cytometry;Future;Genes;genetically modified cells;Glioma;Goals;Growth;Hematologic Neoplasms;Histology;Human;Image;Immune;Immunocompetent;immunogenic;Implant;improved;In Vitro;in vivo;in vivo imaging;in vivo two-photon imaging;Infiltration;Injections;innovation;insight;Intracranial Neoplasms;Intravenous;Investigation;Kinetics;knock-down;Laser Scanning Microscopy;leukemia/lymphoma;Location;Lymphoma cell;Malignant - descriptor;Malignant Glioma;Malignant neoplasm of brain;Mammalian Cell;Measures;Mediating;Microscopy;Modality;Modeling;Molecular;molecular phenotype;Morbidity - disease rate;mouse model;Mus;neoplasm immunotherapy;neoplastic cell;nestin protein;neural;neuroimaging;neurovascular;neurovascular unit;novel;Oncogenes;Oncogenic;Optics;overexpression;Patients;PDGFA gene;PDGFB gene;Positioning Attribute;postnatal;Predisposition;progenitor;programs;Proliferating;promoter;Reporter;Resolution;Route;Signal Transduction;skull implant;stem cells;Study models;Surface;Symptoms;System;T cell infiltration;T-Cell Activation;T-Lymphocyte;TCR Activation;Testing;Therapeutic;Time;Tissues;tool;trafficking;Transgenes;Transgenic Mice;Transgenic Organisms;Translational Research;transmission process;Travel;tumor;tumor growth;tumor microenvironment;tumor progression;Tva receptor;two photon microscopy;two-photon;vector;Viral;Virus;Visualization;Work

PROJECT_TITLE: Brain Tumor CAR T Mouse Model

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Pain Research;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative A substantial number of people infected with COVID-19 experience persistent debilitating symptoms for months or years after the initial infection, consistent with post-acute sequelae of COVID-19 (PASC). There is an urgent need for research that identifies effective treatment strategies for the growing number of patients with PASC, about half of whom have persistent pain. This feasibility study will lay the foundation for a large trial of acupuncture, which has been found effective for chronic pain but has not yet been studied for persons with PASC.

PI_NAMEs: GENTILE, NIKKI  (contact)

PROGRAM_OFFICER_NAME: JEAN-FRANCOIS, BEDA

PROJECT_TERMS: Acupuncture Therapy;Address;Adherence;Affect;Area;arm;Body System;care seeking;Caring;Chinese Traditional Medicine;chronic pain;Clinic;Clinical Trials;common symptom;Communication;Complex;COVID-19 impact;daily functioning;debilitating symptom;early phase clinical trial;effective therapy;Effectiveness;effectiveness evaluation;Exclusion;experience;Feasibility Studies;feasibility trial;follow-up;Foundations;functional improvement;Healthcare Systems;improved;improved outcome;Individual;Infection;Inflammation;innovation;instrument;Integrative Medicine;Intervention;Interview;Language;Learning;Long COVID;Manuals;Medical;mind/body;National Center for Complementary and Integrative Health;operation;Pain;pain reduction;pain relief;Participant;participant retention;Patient-Focused Outcomes;Patients;Persistent pain;Persons;pilot test;Post-Acute Sequelae of SARS-CoV-2 Infection;post-COVID-19;pragmatic randomized trial;primary care clinic;Procedures;Protocols documentation;Quality of life;Questionnaires;Randomized;randomized, clinical trials;Recovery;recruit;Rehabilitation therapy;Reporting;Research;response;Sample Size;SARS-CoV-2 infection;Site;Specific qualifier value;success;Suggestion;Symptoms;tool;treatment arm;treatment as usual;Treatment Protocols;treatment strategy;trial comparing;Universities;Washington;whole health;Work

PROJECT_TITLE: Pain Relief with Integrative Medicine (PRIMEe)?: Feasibility Trial of Acupuncture for Long COVID

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 MH (05)]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cerebrovascular;Childhood Injury;Clinical Research;Infant Mortality;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Stroke;Unintentional Childhood Injury

ORG_CITY: MADISON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Health Relevance Millions of human infants sustain a brain injury each year but our means to visualize cell death in their brains are limited. We have been able to image cell death in cancer and the brains of non-human primates using quantitative ultrasound (QUS). Here we propose to use QUS in typically developing neonates, and neonates with perinatal asphyxia, aiming to show that QUS features change within brain regions that suffer injury due to perinatal asphyxia and that QUS can be useful as a bedside tool to study cell death in the brains of human infants.

PI_NAMEs: IKONOMIDOU, HRISSANTHI  (contact);ROSADO-MENDEZ, IVAN MIGUEL

PROGRAM_OFFICER_NAME: SANTOS SCHMIDT, AUGUSTO FREDERICO

PROJECT_TERMS: Acoustics;Address;Affect;Age;Anesthesia procedures;Anesthetics;Anisotropy;Anticonvulsants;Apoptosis;Apoptotic;Area;Asphyxia;Asphyxia Neonatorum;Autophagocytosis;Basal Ganglia;Brain;Brain Hypoxia-Ischemia;Brain imaging;Brain Injuries;Brain region;Caring;caudate nucleus;Cell Death;Cell Survival;Cells;cellular imaging;chemotherapy;Clinical;Clinical Treatment;Complement;Contrast Media;cost;Critical Illness;Data;Detection;Diffusion;Drug Exposure;Evolution;Exhibits;Exposure to;Frequencies;fundamental research;Globus Pallidus;gray matter;Health;Hemorrhage;Heterogeneity;Histologic;Human;Hypoxic-Ischemic Brain Injury;Image;imaging modality;In Vitro;in vivo;infancy;Infant;Infant Mortality;Infection;Injury;interest;intervention effect;Knowledge;Macaca;Magnetic Resonance Imaging;Malignant Neoplasms;Mammary Neoplasms;Maps;Measurement;Methods;Necrosis;Neonatal;neonatal brain;neonatal exposure;neonatal human;neonate;Neurologic;neuroprotection;Newborn Infant;nonhuman primate;Oncology;Patients;Perinatal;Pilot Projects;portability;predicting response;Prediction of Response to Therapy;predictive marker;Prognosis;Property;putamen;quantitative ultrasound;Reproducibility;Research;response;Risk;Rodent;sedative;Seizures;Sensitivity and Specificity;Severities;sevoflurane;Signal Transduction;Stroke;Techniques;Technology;Testing;Thalamic structure;Time;Tissues;tool;Transducers;translational study;Trauma;tumor;Ultrasonography;ultrasound;Visualization;Work

PROJECT_TITLE: Quantitative Ultrasound Imaging of the Neonatal Brain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Rare Diseases;Scleroderma;Transplantation;Wound Healing and Care

ORG_CITY: NEW HAVEN

ORG_DEPT: DERMATOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE Scleroderma (systemic sclerosis) is an immune mediated fibrotic disease that results high patient morbidity and mortality due to dysfunction of the skin and internal organs. This proposal evaluates how antigen independent activation of CD4+ T cells (bystander effect) regulates fibrosis pathogenesis in mouse models. By understanding the signaling mechanisms that drive bystander T cell activation and their effects on fibroblasts, we will gain better understanding of disease pathogenesis and may identify new interventions to help improve patients’ lives.

PI_NAMEs: ODELL, IAN D (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Address;Affect;Alleles;antifibrotic treatment;Antigens;Autoimmune Diseases;Autoimmunity;Bleomycin;Blood;Bystander Effect;CD4 Positive T Lymphocytes;Cell Count;Cell Physiology;Cells;Cellular biology;Cessation of life;chronic graft versus host disease;chronic inflammatory disease;Clinical;Cutaneous sclerosis;cytokine;Cytokine Signaling;Data;Disease;disease model;drug development;Extracellular Matrix;Family;Family member;Fibroblasts;Fibrosis;Functional disorder;Genes;Goals;graft vs host disease;Helper-Inducer T-Lymphocyte;Histocompatibility;Human;IL17 gene;IL18 gene;Immune;Immune response;improved;In Vitro;in vivo;Individual;Infection;Inflammatory;inhibitor;insight;Interferon Type II;Interleukin-1;Interleukin-13;Intervention;Knowledge;Measures;Mediating;Minor;Modeling;Morbidity - disease rate;mortality;mouse model;Multiple Sclerosis;Mus;Organ;Outcome;Ovalbumin;Pathogenesis;Pathologic;Patients;Production;Proteins;response;Scleroderma;Severities;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Skin;skin disorder;skin fibrosis;Splenocyte;Stem cell transplant;Systemic Scleroderma;T-Cell Activation;T-Independent Antigens;T-Lymphocyte;Testing;therapy development;Transplantation;Validation

PROJECT_TITLE: Interrogation of T cell Bystander Activation in Scleroderma

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Contraception/Reproduction;Fibroid Tumors (Uterine);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infertility;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Gynecologic disorders are diagnosed in up to 30% of reproductive-aged North American women in their lifetime and they are associated with substantial morbidity, reduced quality of life, and high health care costs. The proposed study will evaluate the extent to which child abuse is associated with three highly prevalent and debilitating gynecologic diseases: uterine fibroids, endometriosis, and polycystic ovarian syndrome. The proposed research will provide important information to patients and clinicians about the importance of child abuse for development of gynecologic disease.

PI_NAMEs: BOYNTON-JARRETT, RENEE DANIELLE;WISE, LAUREN A (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: Address;Adolescence;Adult;adverse childhood events;Adverse effects;Affect;aged;American;Anxiety;Area;Attenuated;Behavior;biological adaptation to stress;black women;Black, Indigenous, People of Color;Buffers;Canada;Censuses;Characteristics;Child Abuse;Child Sexual Abuse;Childhood;cohesion;cohort;Collection;Conceptions;coping;Coping Skills;Data;Data Collection;Development;Diagnosis;Diet;Discrimination;Disease;Emotional;endometriosis;Enrollment;Equipment and supply inventories;Exposure to;Female;Female Genital Diseases;Fertility;Financial Hardship;follow-up;Frequencies;Funding;Geography;Gonadal Steroid Hormones;Gynecologic;Health;Health Care Costs;Healthcare;high risk;high risk population;hypothalamic-pituitary-adrenal axis;Incidence;indexing;Individual;Infertility;Infrastructure;Interdisciplinary Study;interest;Intervention;Investigation;Lead;Life;Life Cycle Stages;life span;Link;Long-Term Effects;Measures;Mediating;Mediator;Medical History;Medical Records;Menorrhagia;Mental Depression;Mental Health;Morbidity - disease rate;National Institute of Child Health and Human Development;Neighborhoods;Pain;Parents;Participant;Pathway interactions;Patients;perinatal outcomes;Pharmaceutical Preparations;physical abuse;Polycystic Ovary Syndrome;Positioning Attribute;Post-Traumatic Stress Disorders;Postpartum Period;Pregnancy;Publishing;Quality of life;Questionnaires;racial diversity;Regulation;Reporting;reproductive;Research;resilience;resilience factor;resilience scale;Resources;Risk;Role;Sexual abuse;social;social health determinants;Social Network;Social support;sociodemographics;Spontaneous abortion;Stress;study population;Trauma;United States;United States National Institutes of Health;Uterine Fibroids;Validation;Victimization;White Women;Woman;Work

PROJECT_TITLE: Child Abuse and Risk of Gynecologic Disease in a North American Cohort

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


NIH_SPENDING_CATS: Hematology;Immunotherapy;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE Endogenous thymic regeneration is a crucial process that enables restoration of immune competence after damage caused by everyday insults like stress and infection. However, thymic regenerative capacity diminishes with age and after severe injury such as that caused by chemotherapy and the conditioning required for successful hematopoietic stem cell transplant (HCT); leading to a prolonged period of lymphopenia that detrimentally impacts transplant outcomes. In this proposal we seek to understand the mechanisms that govern this regenerative response so that they may be exploited into rational therapeutic strategies to boost thymic function and T cell reconstitution in recipients of HCT; which could have profound beneficial effects in outcomes following HCT.

PI_NAMEs: DUDAKOV, JARROD  (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Acute;Age;Allogenic;Apoptosis;BMP4;cancer therapy;Cell Death;Cells;chemotherapy;Clinical;conditioning;Data;Endothelial Cells;Epithelial Cells;epithelium regeneration;Equilibrium;Generations;GPR39 gene;graft vs host disease;Hematopoietic Stem Cell Transplantation;Immunocompetence;immunogenic cell death;Immunologics;improved;Infection;Injury;innovation;interleukin-22;interleukin-23;Lead;life span;Lymphoid Cell;Lymphopenia;Mediating;Molecular;mouse model;Natural regeneration;Outcome;Pathway interactions;Pattern;Process;Production;programs;Radiation Injuries;receptor;Recovery;regenerative;Regenerative capacity;Regenerative pathway;Regenerative response;repaired;reparative capacity;Research;response;restoration;severe injury;sex;Signal Transduction;Site;Stress;T cell reconstitution;T-Cell Development;T-Lymphocyte;Therapeutic;therapeutic target;Thymic epithelial cell;thymic regeneration;thymocyte;Thymus Gland;tissue regeneration;Transplant Recipients;Transplantation

PROJECT_TITLE: Promoting T cell reconstitution after hematopoietic cell transplantation


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: PORTLAND

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Optical coherence tomography (OCT) is a widely used ophthalmic imaging technology uniquely able to image the eye with micron resolution over a large 3-dimensional volume. The proposed research will push its performance on the cutting edge of resolution, speed, range, and field of view, and investigate applications in retinoblastoma, the most common primary intraocular malignancy of childhood.

PI_NAMEs: JIAN, YIFAN  (contact);SKALET, ALISON H;VAKOC, BENJAMIN JAMES

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: 3-Dimensional;Address;Affect;Age;autosome;cancer imaging;Child;Cicatrix;Clinical;clinical application;clinical care;clinical imaging;Clinical Research;Computer software;Data;Death Rate;density;design;Detection;Diagnosis;Disease;Early Diagnosis;Early treatment;Evaluation;Exclusion;Eye;Family history of;frequency comb;high risk;Image;imaging study;imaging system;Imaging technology;improved;Inherited;innovation;innovative technologies;instrument;instrumentation;Investigation;Lasers;Malignant Childhood Neoplasm;Malignant Neoplasms;Measurement;Methodology;Methods;Microscope;millimeter;Modeling;Monitor;next generation;novel;novel strategies;open innovation;Ophthalmoscopy;Optical Coherence Tomography;Pathologic;pediatric patients;Performance;Peripheral;Physiologic pulse;Pilot Projects;prevent;prototype;real-time images;Research;research clinical testing;Resolution;Retina;retinal imaging;Retinoblastoma;Risk;Sampling;Scanning;screening;Sedation procedure;Source;Speed;standard of care;Stretching;Support System;Surface;System;Technology;Three-Dimensional Imaging;treatment response;tumor;Tumor Volume;Update;Visual impairment

PROJECT_TITLE: Panretinal Circular Ranging OCT for Retinoblastoma


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurosciences;Prevention;Substance Misuse

ORG_CITY: BOYS TOWN

ORG_NAME: FATHER FLANAGAN'S BOYS' HOME

ORG_STATE: NE

PHR: Project Narrative Magnetoencephalographic (MEG) imaging is a noninvasive method for mapping human brain dynamics that has been used with major success, by our group and others, to identify neural markers of HIV-related cognitive decline and cannabis use disorder. The first next-generation MEG instruments were recently released, and these systems have significantly improved the precision of dynamic functional brain mapping and enabled many longstanding questions to be rigorously tested. The proposed project will examine such questions by probing whether HIV-related cognitive decline is primarily due to cortical or subcortical aberrations and whether the seemingly beneficial effects of regular cannabis use on brain function in adults with HIV are due to alterations in cortical or subcortical dynamics and circuitry.

PI_NAMEs: WILSON, TONY W (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adult;Affect;Area;Award;Biological Markers;Brain;brain dysfunction;Brain Mapping;Cannabis;Cognitive;cognitive function;cognitive task;comorbidity;Complication;Consensus;diagnostic biomarker;Diagnostic tests;Disease;Dose;Economics;Exhibits;expectation;experimental study;Follow-Up Studies;Functional disorder;General Population;Generations;Goals;Heel;HIV;HIV Infections;HIV/AIDS;Human;imaging system;Impaired cognition;Impairment;improved;indexing;instrument;instrumentation;interest;Life Expectancy;Link;Magnetoencephalography;Maps;marijuana use;marijuana use disorder;Measurement;medication compliance;Methods;Modernization;neural;neuroAIDS;neuroimaging;Neurologic;Neurology;Neurons;neuropathology;neurophysiology;neuroprotection;Neuropsychological Tests;next generation;NIH Office of AIDS Research;Noise;Paper;Pathologic;Performance;Persons;Population;Publishing;Quality of life;Reporting;Research;Research Support;response;Risk;Secondary to;Series;Signal Transduction;Structure;substance use;Substance Use Disorder;success;System;Targeted Research;Technology;Testing;Thalamic structure;Time;tool;Unemployment;United States;United States National Institutes of Health;Viral;Western World;Work

PROJECT_TITLE: Next-Generation MEG Imaging for Quantifying Cortical-Subcortical Dynamics in the Context of HIV and Cannabis Use

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 TXT-E (A2)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Narrative Racial disparities in Alzheimer’s disease and related dementias (ADRD) have been well documented and there is increasing scientific evidence that early-life education is a key modifiable risk factor for ADRD. We propose leveraging and expanding an existing cohort of autoworkers at General Motors (GM) to test the hypothesis that, despite having similar jobs and access to healthcare in midlife, access to quality education in early life will be related to ADRD risk, specifically among Black autoworkers. We will characterize the cohort’s ADRD profile by linking to Centers for Medicare and Medicaid Services data, describe early life characteristics by linking to historical census data, and model the association between early life education opportunity and ADRD risk separately among Black and White autoworkers.

PI_NAMEs: COSTELLO, SADIE  (contact)

PROGRAM_OFFICER_NAME: KARRAKER, AMELIA WILKES

PROJECT_TERMS: Adult;Affect;Age;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Black American;Black race;Categories;Censuses;Characteristics;Chemical Exposure;Child;Child Mortality;Childhood;Chronic;Chronic Disease;cohort;Data;dementia risk;Development;Diagnosis;Disease;Disparity;early childhood;early life exposure;Education;educational atmosphere;Employment;Environment;Epidemiologist;experience;Exposure to;Future;Goals;Health;health care availability;Health Policy;Hour;Household;Individual;Intervention;Knowledge;late life;Life;Link;Medical;member;Michigan;middle age;migration;Modeling;modifiable risk;Motor;Names;Occupational;Occupational Exposure;Occupations;older adult;Plants;Quality of Care;Race;racial disparity;racial health disparity;Racial Segregation;Records;Research;Schools;segregation;Social Security Number;Statistical Models;study population;System;Testing;Time;United States Centers for Medicare and Medicaid Services;Work;Workplace

PROJECT_TITLE: Disparities in early life educational environment and AD/ADRD: leveraging administrative linkages in a unique occupational cohort

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Prevention;Schizophrenia;Serious Mental Illness

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative By the year 2050, the US population over age 65 will double and the population over age 85 will increase 5-fold, so the large and increasing number of older individuals living with schizophrenia will need more effective services. Older adults with schizophrenia are at greater risk for cognitive and functional decline leading to premature institutionalization. The proposed clinical trial of a psychosocial rehabilitation intervention specifically targeting improvement in cognition and functioning in older individuals living with schizophrenia is greatly needed and could have a profound effect on patients, family members, society and the economy.

PI_NAMEs: GRANHOLM, ERIC L (contact);RAJJI, TAREK KHALIL

PROGRAM_OFFICER_NAME: EVANS, JOVIER D

PROJECT_TERMS: Adult;Age;aged;arm;Behavioral;Clinical;Clinical Trials;Cognition;Cognitive;cognitive enhancement;confirmatory trial;Data;Dose;Dropout;effective therapy;effectiveness trial;Enrollment;evidence base;Evidence based intervention;executive function;experience;Family member;follow-up;functional decline;functional disability;group intervention;human old age (65+);Impaired cognition;improved;Independent Living;Individual;Institutionalization;Intervention;late life;Learning Skill;Longitudinal Studies;Measures;Mediating;middle age;older adult;Older Population;Participant;Patients;Persons;Phase;Population;premature;prevent;primary outcome;psychosocial;psychosocial rehabilitation;Randomized;Randomized, Controlled Trials;Recommendation;Risk;Sampling;Schizophrenia;Services;Site;skills;skills training;social skills;Societies;Surveys;Testing;Training;Training Activity;Training Programs;treatment as usual;Uncertainty;Work

PROJECT_TITLE: Optimizing Cognitive Behavioral Social Skills Training with Executive Function Training for Older Adults with Schizophrenia

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-N (06)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Infectious Diseases;Rare Diseases

PHR: PROJECT NARRATIVE Optical coherence tomography (OCT) is a widely used ophthalmic imaging technology uniquely able to image the eye with micron resolution over a large 3-dimensional volume. The proposed research will push its performance on the cutting edge of image acquisition speed and resolution, and explore applications in common blinding conditions including corneal infections and keratoconus.

PI_NAMEs: JIAN, YIFAN  (contact);REDD, TRAVIS KENNETH

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: 3-Dimensional;Adoption;Amoeba genus;Anterior;antimicrobial;Award;Bacteria;Biological;Blindness;Cadaver;Cells;Clinical;clinical diagnosis;clinical practice;Clinical Research;clinically relevant;Collagen;Confocal Microscopy;Cornea;Corneal Diseases;corneal scar;Corneal Stroma;Corneal Ulcer;cost;cost effective;crosslink;Data;Detection;Development;Diagnosis;Diagnostic;Diagnostic Procedure;digital;Dimensions;disease diagnosis;Early Diagnosis;Etiology;Evaluation;Eye;fungus;Future;Glass;Goals;Image;image processing;imaging modality;Imaging technology;impression;improved;improved outcome;in vivo;Infection;innovation;Invaded;Keratitis;Keratoconus;Keratoplasty;Light;Machine Learning;Methods;Microbe;microbial;Microscopic;Microscopy;Modality;Modeling;novel strategies;operation;Ophthalmologist;Ophthalmology;Optical Coherence Tomography;Optics;Organism;Oryctolagus cuniculus;Outcome;parallel computer;pathogen;Patients;Performance;Pilot Projects;pragmatic implementation;Procedures;Protozoa;real-time images;reflectance confocal microscopy;Research;Resolution;Scanning;Shapes;Site;Source;Specialist;Speed;Structure;System;targeted treatment;Technical Expertise;Technology;Three-Dimensional Imaging;tomography;ultra high resolution;usability;Variant;Visual;Visual impairment;Visualization

PROJECT_TITLE: High-throughput optical coherence microscopy for diagnostic evaluation of corneal disease


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Genetics;Machine Learning and Artificial Intelligence;Pediatric;Precision Medicine

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Type 2 diabetes(T2D) is increasing at an alarming rate in youth and can lead to devastating long-term consequences, necessitating appropriate risk stratification and precise treatment strategies right from the onset of disease. We will use machine-learning based clinical and genomic clustering methods in existing pediatric datasets to identify groups of youth with T2D at highest risk for complications and most likely to fail metformin treatment, based on underlying biological mechanisms. These results will generate a prediction model and provide a framework for precision medicine-based dosing of metformin and other drug classes in youth with T2D.

PI_NAMEs: SRINIVASAN, SHYLAJA  (contact)

PROGRAM_OFFICER_NAME: LINDER, BARBARA

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;Adverse effects;Affect;Age;Algorithms;Automobile Driving;biobank;Biological;Biology;Body mass index;Boston;Categories;Childhood;children of color;Classification;Clinical;Clinical Data;clinical development;clinical practice;Computerized Medical Record;Data;Data Set;Development;Diagnosis;Disease;Disease Progression;Dose;effective therapy;emerging adult;Ethnic Origin;Eye;Fatty acid glycerol esters;Functional disorder;Funding;Future;Genetic;Genetic Determinism;genome-wide;genomic data;Genomics;Genotype;Glycosylated hemoglobin A;Goals;Health;Heterogeneity;high risk;improved;Incidence;Individual;individualized medicine;Insulin deficiency;insulin sensitivity;Kidney;Link;Lipids;Liver;Machine Learning;machine learning algorithm;Measures;Mentored Patient-Oriented Research Career Development Award;Metformin;Methods;Microvascular Dysfunction;Modeling;Nerve;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;OGTT;Onset of illness;Outcome;Pathway interactions;Pattern;Pediatric Hospitals;Performance;personalized approach;Pharmaceutical Preparations;pharmacologic;Phenotype;Population;precision medicine;Prediction of Response to Therapy;predictive modeling;Principal Investigator;racial diversity;Regimen;Research;response;Risk;risk prediction;risk stratification;SEARCH for Diabetes in Youth;Subgroup;targeted treatment;Techniques;Testing;Therapeutic;Transaminases;treatment response;treatment strategy;unsupervised learning;Variant;Work;Youth

PROJECT_TITLE: Pathophysiological sub-typing of pediatric type 2 diabetes based on clinical and genetic clustering methods

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Neurosciences;Nutrition;Obesity

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Obesity, characterized by an excess of adipose tissue mass, is a major risk factor for many chronic diseases, including type 2 diabetes, cardiovascular disease, and hypertension. Results from our research will provide a better understanding of the molecular mechanism(s) by which vascular endothelial growth factor-A stimulates adipose tissue activity and hence brings about metabolic benefits which will further help to identify new strategies to treat obesity and related diseases.

PI_NAMEs: DAQUINAG, ALEXES  (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Address;Adipocytes;Adipose tissue;angiogenesis;Angiogenic Factor;Angiopoietin-2;Benign;beta-2 Adrenergic Receptors;blood vessel development;Blood Vessels;Brown Fat;Cardiovascular Diseases;Chronic Disease;clinically significant;cofactor;Complex;Data;Development;diet-induced obesity;Disease;Endothelial Cells;Endothelium;Energy Metabolism;Event;Exercise;Fatty acid glycerol esters;Future;Genetic;Genetic Models;Goals;Growth Factor;High Fat Diet;Hypertension;Hypoxia;improved;Induced Neurons;insight;Insulin Resistance;Intake;Learning;Lipolysis;Literature;Mediating;Metabolic;Metabolic Diseases;Metabolism;Modeling;Molecular;mouse model;Nerve;nerve supply;Neurons;neurovascular;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutrient;nutrition;Obesity;Operative Surgical Procedures;overexpression;Oxygen;Pathologic;Pathway interactions;pharmacologic;Physiological;Play;Receptor Signaling;Regulation;Reporting;Research;response;Risk Factors;Role;Signal Pathway;Signal Transduction;Speed;Testing;Tissue Expansion;Tissues;tool;Transgenic Mice;tumor;Up-Regulation;vascular contributions;Vascularization;VEGFA gene

PROJECT_TITLE: Energizing good fat by neurovascular development

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Rural Health;Social Determinants of Health;Stroke

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: PROJECT NARRATIVE The proposed research addresses a gap in clinical decision-making for the assessment of cognitive symptoms after aneurysmal subarachnoid hemorrhage (aSAH; a form of stroke), a burden that is disproportionately felt by African American (AA) patients and those that reside in rural areas. Specifically, we propose to investigate the application of the Quality of Life in Neurological Disorders (Neuro-QoL) patient-reported outcome measures and, in particular, one of its components—the Neuro-QoL cognition short form—as a screening tool to support clinical decision-making and trigger individual, in-depth cognitive assessment post-aSAH. This work will improve health equity by informing new practice guidelines to provide earlier and more accurate assessment of cognitive symptomatology post-aSAH to reduce disparities and improve quality of life (QoL) for survivors.

PI_NAMEs: STANFILL, ANSLEY  (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: Address;Affect;African American;African American population;Age;Aneurysmal Subarachnoid Hemorrhages;battery life;Benchmarking;Caring;Characteristics;Clinical;Clinical Data;clinical decision support;clinical decision-making;clinical practice;clinical translation;Cognition;Cognitive;cognitive testing;cost effective;Data;Detection;Diagnostic;Discrimination;Disparity;disparity reduction;Education;Employment;Equity;experience;follow-up;Goals;Guidelines;health equity;Impaired cognition;Impairment;improved;improved outcome;Individual;individual patient;innovation;instrument;Intervention;Knowledge;Measurement;Measures;mental state;Modality;neglect;Nervous System Disorder;Neurobehavioral Manifestations;Neurologic;Neuropsychological Tests;Neuropsychology;novel;Outcome;Outcome Measure;Outpatients;Patient Outcomes Assessments;patient response;Patient Self-Report;Patients;personalized intervention;Persons;Phenotype;physical impairment;Population;Practice Guidelines;Proxy;Quality of life;Questionnaires;recruit;Reporting;Research;response;Risk;ROC Curve;Role;rural area;rural dwellers;rural patients;Sampling;screening;Screening procedure;Signal Transduction;social health determinants;Socioeconomic Status;standard measure;Standardization;Stroke;success;Survivors;symptomatology;Symptoms;Testing;tool;Work

PROJECT_TITLE: Promoting cognitive screening and assessment post-aneurysmal subarachnoid hemorrhage for better equity in outcomes

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Neurosciences;Pediatric;Prevention

ORG_CITY: RIVERSIDE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: Project Narrative Understanding the mechanisms of brain development and detecting abnormalities in the early stage of infancy is essential for the early diagnosis of motor disabilities and the design of early intervention programs. Inherent limitations of current neuroimaging tools make large-scale monitoring of neural activity with high spatiotemporal resolution and specificity in young populations performing motor tasks challenging. The proposed study will assess the functional organization of the motor system in awake and behaving infants using functional ultrasound imaging (fUSI), a unique real-time, portable and deep brain functional imaging tool with unprecedented spatiotemporal resolution.

PI_NAMEs: CHRISTOPOULOS, VASILEIOS N (contact);KOKKONI, ELENA

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Acoustics;Activities of Daily Living;Adult;Anatomy;Anterior;Area;Attenuated;awake;Behavioral;Behavioral Paradigm;Biomechanics;Brain;Brain imaging;brain machine interface;Brain region;Childhood;Clinical;Cognitive;cognitive development;cranium;critical period;Data;design;Detection;Development;Developmental Disabilities;Devices;Disease Outbreaks;Early Diagnosis;Early Intervention;Electroencephalography;Environment;Epilepsy;Exclusion;experience;Exposure to;Foundations;Functional Imaging;Functional Magnetic Resonance Imaging;functional near infrared spectroscopy;Future;Goals;hemodynamics;high resolution imaging;Human;Human Development;Image;Imaging Device;imaging study;Imaging technology;infancy;Infant;innovation;Intervention;intervention program;Knowledge;Language Development;Learning;Life;Location;Loudness;machine learning prediction algorithm;Magnetoencephalography;Measures;Modality;Monitor;Monkeys;Morphologic artifacts;Motion;Motor;Motor Activity;motor control;Motor disability;motor impairment;motor rehabilitation;Movement;neonate;neural;neural correlate;neurogenesis;neuroimaging;neuromechanism;Neurosciences;new technology;Noise;novel;Operative Surgical Procedures;Organism;Participant;Penetration;Performance;Population;portability;programs;Resolution;response;Risk;Rodent;Sedation procedure;Self-Help Devices;Signal Transduction;skills;Sleep;spatiotemporal;Specificity;Stimulus;System;Techniques;Technology;temporal measurement;Thinness;Time;tool;Translating;Ultrasonic wave;Ultrasonics;Ultrasonography;ultrasound;Upper Extremity;Work

PROJECT_TITLE: Detection and characterization of motor activity in behaving infants through the use of novel ultrasonic brain imaging technology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-Q (91)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: Cancer-related fatigue (CRF) is a highly prevalent and distressing symptom reported by patients that persists for many after treatment is completed, and is commonly associated with depressive symptoms, decreases in ability to work and care for family members, and decreases in quality of life. In a prospective cohort of oncology patients undergoing combined chemotherapy and radiation therapy (CCRT) with different levels of morning and evening CRF, our first objective is to evaluate for associations between phenotypic and molecular characteristics associated with changes in CRF over time to determine the underlying mechanisms for CTXRF, which could identify potential therapeutic interventions. Our second objective is to develop and evaluate a risk prediction model which would assist clinicians to determine which patients are most likely to experience high levels of CRF during and following CCRT and provide recommendations for activity modifying interventions (e.g., exercise).

PI_NAMEs: KOBER, KORD MICHAEL (contact)

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: Abbreviations;Address;Aftercare;associated symptom;Biological Markers;Cancer Etiology;Cancer Intervention;cancer therapy;Candidate Disease Gene;Caring;Categories;Characteristics;chemotherapy;Chemotherapy and/or radiation;Chemotherapy-Oncologic Procedure;Clinical;clinical development;Clinical Markers;Clinical Research;Combination Drug Therapy;common symptom;cytokine;Data;Data Analyses;data integration;depressive symptoms;differential expression;Distress;Diurnal Rhythm;DNA;effective therapy;Environment;Epigenetic Process;epigenetic variation;Evaluation;Exercise;experience;Family member;Fatigue;Funding;Gene Expression;gene product;Genes;Genetic Variation;genomic data;Grant;high risk;Immunotherapy;Inflammatory;Inherited;innovation;insight;Intervention;Investigation;Knowledge;Malignant Neoplasms;Measurement;Methylation;Modeling;Molecular;molecular marker;Nature;Oncology;Operative Surgical Procedures;Pathway interactions;Patients;Phenotype;predictive modeling;Preparation;Process;Prospective cohort;Quality of life;Radiation therapy;Recommendation;Reporting;Research;response;risk prediction model;RNA;Sample Size;Sampling;Serum;Severities;Symptoms;targeted treatment;Therapeutic Intervention;therapeutic target;Time;Work

PROJECT_TITLE: An Investigation of the Molecular Mechanisms for and Prediction of the Severity of Cancer Chemotherapy-Related Fatigue Using a Multi-staged Integrated Omics Approach


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Bioengineering;Cancer;Cervical Cancer;Contraception/Reproduction;Nanotechnology;Women's Health Research

ORG_CITY: CORVALLIS

ORG_NAME: OREGON STATE UNIVERSITY

PHR: PROJECT NARRATIVE People who use tampons are chronically exposing the mucosal barriers of the vagina and cervix to nanoplastics. It is currently unknown if this route of nanoplastic exposure leads to local infection and chronic health problems. Thus, for people who menstruate to make informed decisions about their use of tampons, the physiological effects of these particles coming in direct contact with vaginal and cervical tissue will be identified.

PI_NAMEs: FOGG, KAITLIN C (contact)

PROGRAM_OFFICER_NAME: RAVICHANDRAN, LINGAMANAIDU V

PROJECT_TERMS: 3-Dimensional;Adsorption;Affect;Architecture;Biocompatible Materials;Biological;Biophysics;Blood;Cell Membrane Permeability;Cervical;Cervix Uteri;Characteristics;Chemicals;Chemistry;Chronic;Complex;Disease;Endometrial Carcinoma;endometriosis;Environment;Epithelium;Exposure to;Female Genital Diseases;Fertility;Focal Infection;Goals;Gynecologic;Health;high throughput screening;hormonal signals;Hygiene;Impairment;in vitro Model;Infection;Inflammation;insight;Libraries;Localized Disease;Malignant neoplasm of cervix uteri;Membrane;Menstruation;Methods;microphysiology system;Modeling;Molecular;Morphology;Mucous Membrane;nano;nanoparticle;Oxidative Stress;particle;Penetration;Permeability;Persons;Physiological;Plastics;Population;Property;protein folding;protein structure;Proteins;Reporting;Research;Resolution;Risk;Role;Route;Sampling;Shapes;Signal Transduction;Site;Surface;Systemic disease;Tampons;Techniques;Tissues;tool;Vagina;vaginal mucosa

PROJECT_TITLE: The influence of tampon nanoplastic particles on gynecological mucosal barriers

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Brain Disorders;Clinical Research;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: RELEVANCE Recordings of local field potentials (LFPs) from deep brain stimulation (DBS) electrodes have played an important role in expanding physiological understanding of Parkinson’s disease (PD). However, fundamental questions remain unaddressed on the underlying biophysics of LFP signals. The goal of this project is to create patient-specific computational models that enable dissection of the LFP signal at the cellular-level. These research tools will be customized to PD patients implanted with DBS systems.

PI_NAMEs: MCINTYRE, CAMERON  (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Address;Algorithms;Anatomy;Biological Models;Biomedical Engineering;biophysical properties;Biophysics;Boston;Characteristics;Chronic;Clinical;computer infrastructure;Computer Models;Data;Deep Brain Stimulation;Development;Devices;Dissection;Dorsal;Electrodes;engineering design;Evaluation;experimental study;Functional disorder;Goals;Human;Image;Implant;improved;Infrastructure;Investigation;Lateral;Lead;Location;Measurable;Measurement;Modeling;motor symptom;neural;Neurons;Parkinson Disease;patient population;Patients;Physiological;Play;Population;Population Study;Positioning Attribute;Quality of life;Research;Research Project Grants;Research Subjects;Role;Signal Transduction;Structure of subthalamic nucleus;symposium;Synapses;System;Technology;Time;tool

PROJECT_TITLE: Biophysical Characterization of Subthalamic Local Field Potentials in Parkinson's Disease

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Lung;Lung Cancer;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative Smoke-free housing policies in multiunit housing are promising and increasingly widespread interventions to reduce smoking and secondhand smoke exposure. Little research has identified factors that impede compliance with smoke-free housing policies in low-income multiunit housing and test corresponding solutions. The proposed RCT addresses key gaps in knowledge and capitalizes on key scientific opportunities by: 1) leveraging the federal mandate to ban smoking in a public housing system of more than sufficient size to conduct an adequately powered RCT; 2) expanding our understanding of smoke-free policy compliance beyond policy implementation by testing two novel treatments: a) in-residence smoking cessation and b) resident endorsement, while 3) addressing population and location-specific tobacco-related disparities.

PI_NAMEs: HERNANDEZ, DIANA  (contact)

PROGRAM_OFFICER_NAME: LAND, STEPHANIE R

PROJECT_TERMS: Address;Adopted;Adoption;Adult;Affect;Air;Area;arm;authority;Biological Markers;Biological Monitoring;Cessation of life;Cigarette;Cities;Communities;community engagement;Cotinine;Data;density;design;Development;Disparity;Disparity population;disparity reduction;Economics;Effectiveness;Environment;environmental tobacco smoke exposure;ethnic minority;experience;Experimental Designs;Focus Groups;frontier;hazard;Health Benefit;high risk;high risk population;Home;Home environment;Household;Housing;implementation intervention;informant;Interdisciplinary Study;Intervention;Interview;Knowledge;Learning;Location;Low income;Low Income Population;Measures;Methods;Movement;Neighborhoods;New York City;non-smoker;non-smoking;novel;Outcome;Participant;Passive Smoking;Patient Education;patient navigator;Patient Self-Report;Persons;Policies;Policy Compliance;Population;post intervention;Predisposition;premature;preventable death;Process;Property;Provider;Public Housing;racial minority;Random Allocation;Randomized, Controlled Trials;recruit;Reporting;Research;residence;Resources;Sales;Salivary;Sampling;Sensory;Services;Smoke;Smoke-free home;smoke-free policy;Smoker;Smoking;Smoking Behavior;smoking cessation;Smoking Status;social;social media;Source;Surveys;System;Testing;Time;Tobacco;tobacco products;Tobacco use;trial design;United States;ventilation;Vulnerable Populations

PROJECT_TITLE: A randomized controlled trial to support smoke-free policy compliance in public housing


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Nanotechnology;Women's Health Research

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because invasion and metastasis during breast cancer progression are associated with increased mortality, yet the biophysical mechanisms underlying these two processes are not well understood. Therefore, the proposed research on understanding how extracellular matrix malleability regulates the collective invasion and migration of breast cancer cells is relevant to the part of NIH's mission that seeks to develop fundamental knowledge that will help reduce the burdens of human disability and disease. Ultimately, it is anticipated that this study will uncover previously un-described modes of invasion and migration, thereby leading to new diagnostic measures of pre-invasive breast cancer and new therapeutic strategies to block invasion and metastasis.

PI_NAMEs: CHAUDHURI, OVIJIT  (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: Actins;Actomyosin;Award;Basement membrane;Benign;Biocompatible Materials;Biophysical Process;Breast Cancer Cell;breast cancer progression;breast lesion;Bulla;cancer cell;cancer type;Carcinoma;Cell Cycle Progression;cell motility;cell type;Cells;Characteristics;Clinical Trials;Collagen;Collagen Type I;crosslink;density;disability;Disease;Ductal Carcinoma;Elasticity;Endothelium;epigenome;Epithelium;Exhibits;Extracellular Matrix;Extravasation;Failure;Filopodia;Goals;Human;Individual;infiltrating duct carcinoma;innovation;Integrin Binding;Integrins;Intervention;Invaded;Knowledge;Lesion;Ligands;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Epithelial Cell;malignant phenotype;mammary epithelium;Matrix Metalloproteinase Inhibitor;Measures;mechanical properties;Mechanics;Mediating;Mesenchymal;migration;Mission;Mitotic;Modeling;Molecular;Molecular Target;Morphology;mortality;Motility;Nanoporous;Nature;Neoplasm Metastasis;Noninfiltrating Intraductal Carcinoma;novel;novel diagnostics;novel therapeutic intervention;Peptide Hydrolases;pharmacologic;Phase;Physiological;polymerization;Polymers;prevent;Process;Proliferating;Public Health;Research;Resistance;Role;Testing;three dimensional cell culture;Tissues;tumor progression;United States National Institutes of Health;viscoelasticity;Viscosity;Work

PROJECT_TITLE: Role of extracellular matrix malleability in mediating breast cancer cell invasion and migration


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: HINES

ORG_NAME: EDWARD HINES JR VA HOSPITAL

PHR: A great deal of the V.A. mission involves surgical intervention after stroke, head injury and spinal cord injury. A portion of this proposal would provide guidelines to physicians making surgical decisions during reconstructive procedures. Improved efficacy of surgical procedure will greatly aid the rehabilitative process. We will also provide data useful to therapists treating patients conservatively with strength training since the physiological condition of the muscles will be defined. In both cases, these studies will affect a large fraction of the V.A. inpatient and outpatient population and, based on improved outcomes, should result in significant savings of time and energy as well as improved patient independence and function.

PI_NAMEs: LIEBER, RICHARD L. (contact)

PROJECT_TERMS: Affect;Anatomy;Architecture;arm;arm function;biomechanical model;biomechanical test;Biomechanics;Brachial plexus structure;Characteristics;Clinic;Complex;Country;Craniocerebral Trauma;Data;Data Set;design;Devices;Dissection;Elbow;experience;experimental study;Flexor;Goals;Guidelines;haptic feedback;Human;human model;improved;improved outcome;in vivo;Individual;Injury;innovation;Inpatients;joint function;Joints;Knowledge;Lead;Learning;Length;Lesion;Location;Measurement;Measures;mechanical properties;Mechanics;Methods;Military Personnel;military veteran;Mission;Modeling;Motor Neurons;Movement;Muscle;Muscle function;muscle transplantation;muscular structure;Musculoskeletal;Musculoskeletal System;neural;novel;Operating Rooms;Operative Surgical Procedures;Outcome;Outpatients;Patients;Persons;Physicians;Physiological;Population;post stroke;Postoperative Period;Procedures;Process;Property;reconstruction;Reconstructive Surgical Procedures;Recovery;Rehabilitation therapy;Research;research and development;Resolution;Rest;Sarcomeres;Savings;Science;service member;simulation;Skeletal Muscle;Spinal cord injury;strength training;Stroke;Surface;Surgeon;Tendon Transfer;Testing;Time;Tissues;tool;Torque;Training;Transplantation;Transplantation Surgery;Traumatic Brain Injury;Upper Extremity;Validation;Veterans;Work

PROJECT_TITLE: Intraoperative Optimization and Validation of Musculoskeletal Reconstruction

STUDY_SECTION_NAME: Musculoskeletal Health & Function[RRD2]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Nanotechnology;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: OMAHA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

PHR: PROJECT NARRATIVE  Brain-targeted combination therapy has the potential to treat medulloblastoma efficiently. Therefore, we propose a new therapeutic and imaging approach for co-delivery of potent Hh inhibitor and BRD4/PI3K dual inhibitor using ApoE mimetic peptide COG-133 decorated PEG-b-PCC-g-DC polymeric nanoparticles.

PI_NAMEs: COULTER, DONALD ;MAHATO, RAM I. (contact)

PROGRAM_OFFICER_NAME: FOUNTAIN, JANE W

PROJECT_TERMS: 3-Dimensional;analog;antitumor effect;Apolipoprotein E;Apoptosis;Benzene;Binding;Biodistribution;Blood - brain barrier anatomy;blood-brain barrier crossing;Brain;Brain Neoplasms;cancer stem cell;cell growth;cell killing;Cells;Cerebellum;Chemoresistance;chemotherapy;Childhood Brain Neoplasm;Clinical Trials;Combined Modality Therapy;copolymer;CRISPR/Cas technology;Cyclin D1;Cytoplasmic Granules;Development;Dose;Drug Combinations;Drug Delivery Systems;drug development;Drug Kinetics;Drug Transport;effective therapy;Encapsulated;Erinaceidae;Evaluation;Formulation;Genes;genetic makeup;Genetic Transcription;Genetic Variation;Hepatotoxicity;Human;imaging approach;Immune Evasion;Implant;in vivo imaging system;Individual;inhibitor;Injections;innovation;kinase inhibitor;Laboratories;Ligands;Liver;Malignant Neoplasms;MB03;Medulloblastoma;medulloblastoma cell line;Metabolism;meter;Modeling;mouse model;Mus;mutant;Mutate;Mutation;MYC gene;MYCN gene;nanoparticle;nanopolymer;neoplastic cell;nerve stem cell;Neurons;neurotoxic;neurotoxicity;novel;novel therapeutics;Organ;Pathway interactions;patient derived xenograft model;Patients;Peptides;peptidomimetics;Pharmaceutical Preparations;Phosphatidylinositols;Phosphotransferases;Primary Neoplasm;programmed cell death ligand 1;Proliferating;Resistance;resistance mechanism;SHH gene;side effect;Signal Pathway;small molecule;smoothened signaling pathway;stem cell proliferation;System;targeted treatment;technology platform;Therapeutic;therapeutic target;Toxic effect;Transgenic Mice;Transgenic Organisms;tumor;Tumor Burden;Tumor Immunity;tumorigenic;Tumorigenicity;uptake

PROJECT_TITLE: Overcoming Resistance Mechanisms in Hedgehog and Myc-amplified Medulloblastoma

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Neurosciences;Rehabilitation

ORG_CITY: IOWA CITY

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE This research program will elucidate the organization of human brain networks engaged in speech perception using a unique combination of non-invasive and invasive experimental methods. By using direct recordings from the brains of neurosurgical patients, detailed information will be obtained that is not available using conventional non-invasive methods. This information will aid the development of novel approaches to diagnosis, treatment and rehabilitation of patients with a wide range of communication disorders.

PI_NAMEs: HOWARD, MATTHEW A. (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Acoustics;Address;Affect;anatomic imaging;Anatomy;Anterior;Area;Attention;Auditory;Auditory area;Behavioral;Brain;Brain imaging;Brain Injuries;Brain region;Chronic;Clinical;Code;Communication impairment;Complement;Complex;Comprehension;Data;design;Development;Diagnosis;Disease;Electric Stimulation;Electrodes;Electroencephalography;Electrophysiology (science);Excision;expectation;experience;experimental study;Feedback;frontal lobe;Functional disorder;Functional Imaging;Functional Magnetic Resonance Imaging;Goals;Health;Hearing;Hearing problem;Human;imaging modality;improved;Individual;Inferior frontal gyrus;information processing;insight;Knowledge;language processing;Learning;Lesion;Lobe;Location;Maps;Methods;Modeling;Monitor;multidisciplinary;Names;neural;neuroimaging;Neurons;neurosurgery;novel;novel strategies;novel therapeutic intervention;Operative Surgical Procedures;Patients;Pattern;Performance;Physiology;Play;Process;programs;Projections and Predictions;Property;Rehabilitation therapy;Research;Research Personnel;Resources;Role;Scalp structure;Secondary to;Seizures;Semantics;Sensory;Signal Transduction;Site;sound;Speech;Speech Perception;speech processing;Speech Sound;Stimulus;System;Techniques;Temporal Lobe;Testing

PROJECT_TITLE: Human Auditory Cortex Physiology

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cystic Fibrosis;Genetics;Lung;Orphan Drug;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative The goal of this project is to more fully understand how the gut behaves in patients with Cystic Fibrosis. Using fruit flies as a model organism I will study both environmental factors like bacteria and genetic factors that impact the outcomes of Cystic Fibrosis in patients. This work will establish fruit flies as a model to study CF and may uncover new drug targets to treat the disease.

PI_NAMEs: LANE, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: absorption;Affect;autosome;Bacteria;Biological Assay;Candidate Disease Gene;Cell Line;Cells;Chloride Channels;Chlorides;Clinical;clinical phenotype;clinically relevant;cohort;Colon;cost;Cystic Fibrosis;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Dehydration;differential expression;Disease;disease phenotype;Disease Progression;Drosophila genus;drug action;dysbiosis;Environmental Risk Factor;Epithelial Cells;epithelial Na+ channel;Epithelium;European;fly;gastrointestinal epithelium;Genes;Genetic;Genetic Diseases;Genetic Screening;Germ-Free;Goals;Human;inhibitor;insight;Intestinal Motility;Intestines;Ion Channel;knock-down;life span;loss of function mutation;Lung;Messenger RNA;microbiome;MicroRNAs;model organism;Modeling;molecular targeted therapies;Mucins;Mucous body substance;mutant;Mutation;new therapeutic target;Newborn Infant;Organ;Orthologous Gene;Other Genetics;Outcome;overexpression;Pancreas;Pathology;Patients;Persons;Phenotype;Proliferating;recessive genetic trait;Regulation;Regulator Genes;reproductive organ;Respiratory System;sensor;Signal Pathway;Sinus;Sodium;Surface;Symptoms;Therapeutic;therapeutic target;Time;Toxic effect;transcription factor;United States;Up-Regulation;Water;Work

PROJECT_TITLE: Drosophila as a model to study modifiers of Cystic Fibrosis


ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE Metabolites act as important signaling molecules in both the adipose and immune systems. A type of adipose tissue called brown fat has been shown to be anti-inflammatory but the mechanism for this is unclear. An exciting and interesting idea is that manipulating how these metabolites signal to fat and immune cells could be a new way of treating metabolic disease. ! !

PI_NAMEs: MILLS, EVANNA LOUISA (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: adipocyte biology;Adipocytes;Adipose tissue;Anti-Inflammatory Agents;Brown Fat;Cardiovascular Diseases;Cell Culture Techniques;Cell membrane;Cell Physiology;Cells;Circulation;Coupled;Data;diet-induced obesity;Disease;Environment;Etiology;experience;experimental study;extracellular;Fatty acid glycerol esters;G-Protein-Coupled Receptors;Genetic;genetic manipulation;Glucose Intolerance;Immune;Immune system;Immunology;In Vitro;in vivo;in vivo Model;Inflammation;Inflammatory;Intervention;Knockout Mice;Ligation;Link;Lipids;liquid chromatography mass spectrometry;liver inflammation;loss of function;Malignant neoplasm of liver;Mass Spectrum Analysis;Mediating;Membrane Transport Proteins;Metabolic;metabolic abnormality assessment;Metabolic Diseases;metabolic phenotype;Metabolism;Methods;Mitochondria;Modeling;Molecular;molecular phenotype;mouse model;Nature;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutic intervention;Obesity;obesity treatment;obesogenic;Organ;Pathogenesis;Pathology;Peripheral;pharmacologic;Phenotype;Physiological;Process;Proteins;receptor;Research;Research Personnel;Respiration;Risk Factors;Role;Signal Transduction;Signaling Molecule;skills;Stimulus;success;Succinates;Testing;Therapeutic;Thermogenesis;Tricarboxylic Acids;uptake;Visceral;Work

PROJECT_TITLE: Mechanistic characterization of the anti-inflammatory function of thermogenic fat for the treatment of metabolic disorders

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

ORG_CITY: DOVER

ORG_DEPT: BIOLOGY

ORG_NAME: DELAWARE STATE UNIVERSITY

ORG_STATE: DE

PHR: Our program will involve undergraduate students from under-represented backgrounds in a summer research experience and well-integrated developmental activities that will increase student preparation and skills to successfully pursue the baccalaureate and graduate degrees in biomedical and behavioral sciences.

PI_NAMEs: HARRINGTON, MELISSA A (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: African American;Area;Bachelor's Degree;Behavioral Research;Behavioral Sciences;Biomedical Research;Cancer Education Grant Program;Centers of Research Excellence;college;Communities;community college;Delaware;design;Development;Doctor of Philosophy;Educational workshop;Enrollment;experience;Faculty;Funding;Graduate Degree;graduate school;Grant;Historically Black Colleges and Universities;Institution;inter-institutional;interest;Length;literacy;meetings;member;Minority;Minority Groups;National Institute of General Medical Sciences;Neurosciences;Neurosciences Research;Participant;Pennsylvania;Play;Positioning Attribute;Preparation;Problem Solving;Professional counselor;Program Research Project Grants;programs;Reading;recruit;Research;Research Personnel;Research Project Grants;Scholars Program;Schools;Science;scientific literacy;Scientist;Self Efficacy;skills;STEM field;student participation;Students;success;summer program;summer research;supportive environment;symposium;technical college;undergraduate research experience;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;virtual

PROJECT_TITLE: A Summer Undergraduate Research Program in Neuroscience at an HBCU


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Transplantation

ORG_NAME: SCHEPENS EYE RESEARCH INSTITUTE

PHR: Project Narrative The mammalian retina does not possess the capacity to regenerate; thus, progressive retinal neuron death leads to irreversible vision loss in glaucoma optic neuropathies and other degenerative diseases of the retina and optic nerve. Cell transplantation has been proposed to restore the retinal neurocircuitry; however, current state-of-the- art studies show that most donor retinal ganglion cells (RGCs) do not integrate into the ganglion cell layer and connect with the existing host retinal neurons. This research proposal will investigate the role that Down Syndrome Cell Adhesion Molecule (DSCAM) has in directing donor RGC migration and synapse formation with their natural connecting points in the retina.

PI_NAMEs: SOUCY, JONATHAN R (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Affect;age related;Animals;Biological Models;Blindness;CDK5 gene;Cell Adhesion Molecules;Cell Communication;cell motility;cell replacement therapy;Cell Separation;Cell Surface Receptors;Cell Survival;Cell Transplantation;Cells;Cellular biology;Cellular Morphology;Cerebrum;Colcemid;Cues;Cytoskeleton;Development;Disease;Dose;Down Syndrome Cell Adhesion Molecule;Down's Syndrome;economic impact;Electrophysiology (science);Event;experimental study;gain of function;Ganglion Cell Layer;Glaucoma;Harvest;Image;Immunohistochemistry;improved;induced pluripotent stem cell;inhibitor;intravitreal injection;Investigation;Isogenic transplantation;Lead;Life Expectancy;loss of function;loss of function mutation;Masks;Mediating;migration;Modality;Molecular;mosaic;mosaic pattern;multi-electrode arrays;Mus;Muscle fasciculation;Natural regeneration;neural;neural circuit;Neurodegenerative Disorders;neuron loss;neuronal cell body;neuronal replacement;Neurons;Optic Nerve;optic nerve disorder;Outcome;Peptide Hydrolases;Persons;Pharmaceutical Preparations;Population;Positioning Attribute;preservation;prevent;Process;receptor expression;repaired;Reproducibility;Research Proposals;Retina;retina transplantation;retinal damage;Retinal Degeneration;Retinal Ganglion Cells;retinal neuron;retinogenesis;Role;Series;sight restoration;Signal Transduction;Small Interfering RNA;small molecule;socioeconomics;Spinal;stem cell differentiation;stem cells;Surface;synaptogenesis;System;transcriptome;Transplantation;Trisomy;United States

PROJECT_TITLE: Regulating cell-cell interactions to improve donor retinal ganglion cell integration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: TDP-43 is a protein central to devastating and neurological disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). TDP-43-associated pathology is also present in Alzheimer's disease and other neurodegenerative disorders. Our work has revealed important findings on the aggregation of TDP-43 and promises to be a significant and revolutionary step forward in generating tools for effectively defining therapeutic and diagnostic strategies.

PI_NAMEs: AYALA, YUNA  (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Acceleration;Affect;alpha synuclein;ALS patients;Alzheimer's Disease;Alzheimer's disease patient;Amyloid;Amyloid beta-Protein;Amyotrophic Lateral Sclerosis;Antibodies;Brain;Cell model;Cells;Characteristics;Collaborations;combat;Complex;Core Assembly;Cytoplasm;detection method;diagnostic biomarker;diagnostic strategy;Disease;Disease Marker;disease model;Disease Progression;DNA-Binding Proteins;Early Diagnosis;Electrophoresis;Epitopes;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Future;gain of function;Goals;Grant;hnRNP A1;Human;In Vitro;in vivo;in vivo Model;Injections;insight;Lesion;Link;link protein;Mediating;Methods;Modeling;Molecular;Mus;Mutagens;Mutation;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neurotoxicity;Parkinson Disease;Pathogenesis;Pathologic;Pathology;Patients;phosphoneuroprotein 14;prevent;Process;protein aggregation;Protein Isoforms;protein misfolding;protein purification;Protein Region;protein TDP-43;Proteins;Proteolysis;proteotoxicity;Reagent;recruit;RNA;RNA Recognition Motif;RNA-Binding Proteins;Role;Source;stress granule;tau Proteins;TDP-43 aggregation;Testing;Therapeutic;therapeutically effective;Time;Tissues;tool;tool development;Universities;Variant;Washington;Work

PROJECT_TITLE: Role of oligomeric TDP-43 aggregate intermediates in ALS and frontotemporal dementia

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Cancer;Clinical Research;Lung;Lung Cancer;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_NAME: CHILDREN'S HOSPITALS AND CLINICS

ORG_STATE: MN

PHR: NARRATIVE Clinical validation and translation of blood-based biomarkers is the next necessary step in our efforts to cure PPB and other DICER1-related cancers. This global partnership focuses on the clinical validation of novel circulating tumor DNA-based "liquid biopsy" assays for quantification of tumor burden and detection of treatment response in DICER1-related cancers. Development of novel biomarkers will improve outcomes for children and adults with DICER1-related cancers through early diagnosis, risk stratification and intervention and development of novel therapies.

PI_NAMEs: SCHULTZ, KRIS ANN PINEKENSTEIN (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: 7 year old;Acceleration;Acute;Adult;Alleles;Biological Assay;Biological Markers;biomarker validation;Blood;blood-based biomarker;Brain Neoplasms;Cancer Burden;cancer cell;Caring;cell free DNA;Cessation of life;Chemoresistance;chemotherapy;Chest;chest computed tomography;Child;Childhood;China;Clinical;clinical practice;Clinical Trials;clinically significant;Codon Nucleotides;Collaborations;Communities;companion diagnostics;Cystic Neoplasm;data registry;design;Detection;Development;Diagnosis;Diagnostic;digital;Disease;Dose;early childhood;Early Diagnosis;Embryonic Development;Enrollment;Excision;Face;Future;Germ Lines;high risk;improved;improved outcome;Industrialization;Infant;International;Intervention;Kidney Neoplasms;liquid biopsy;Malignant Childhood Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Metastatic malignant neoplasm to brain;Methods;Minnesota;Missense Mutation;Molecular;Monitor;Morbidity - disease rate;mortality risk;mutant;Mutation;new technology;novel;novel marker;novel therapeutics;Operative Surgical Procedures;ovarian neoplasm;Pathogenesis;Pathogenicity;Pathologic;Pediatric Hospitals;Pediatric Oncology;Pleuropulmonary Blastoma;Preclinical Drug Development;Predisposition;Prognosis;Progressive Disease;Radiation;radiation risk;Radiation therapy;rare cancer;Rare Diseases;Recurrence;Recurrent disease;Recurrent tumor;Registries;Research;Residual Neoplasm;Rhabdomyosarcoma;Ribonucleases;Risk;risk minimization;risk stratification;Sarcoma;Scanning;Schedule;Sedation procedure;Sensitivity and Specificity;side effect;Site;Solid;Solid Neoplasm;specific biomarkers;Technology;Testing;therapy resistant;thyroid neoplasm;Toxic effect;translational study;Translations;treatment response;Treatment-related toxicity;tumor;Tumor Burden;tumor DNA;Validation;Variant;Work;X-Ray Computed Tomography;young adult

PROJECT_TITLE: Detecting DICER1: A global partnership to cure pediatric lung cancer


NIH_SPENDING_CATS: Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Head impact exposure in contact sports such as football is a rising concern, since it appears that exposure to repetitive head impacts, even if a concussion is not suspected, may be linked to brain disease later in life and changes in the brain over a single season. This K25 Mentored Quantitative Research Development Award will develop and pilot test an evidence-based intervention to reduce head impact exposure in youth football, involving coaches and parents in the development of the intervention. Formal training in organizational systems theory, intervention planning and evaluation, community engagement, and implementation monitoring will prepare the applicant to lead future studies combining public health sciences and injury biomechanics to develop, test, and improve injury prevention strategies among youth athletes.

PI_NAMEs: URBAN, JILLIAN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: acceptability and feasibility;Address;Adopted;Age;Area;Attitude;Award;Awareness;Biomechanics;Brain;Brain Concussion;Brain Diseases;brain health;Communities;community engaged approach;community engagement;contact sports;Controlled Environment;Data;Data Collection;data integration;design;Development;effective intervention;Effectiveness of Interventions;Epidemiology;Evaluation;evidence base;Evidence based intervention;Evidence based practice;Exposure to;Feedback;Focus Groups;Future;Goals;Guidelines;head impact;Health Sciences;high risk;implementation intervention;implementation process;implementation science;improved;Individual;Injury;injury prevention;Intervention;Interview;junior high school;Knowledge;Lead;Leadership;Life;Link;Literature;Manufactured football;Measures;member;Mentors;Mentorship;Methodology;Methods;Modeling;Monitor;Neurodegenerative Disorders;Outcome;Parents;participant retention;Perception;Pilot Projects;pilot test;Play;Policies;Positioning Attribute;Predisposition;Prevention strategy;Process;programs;Public Health;recruit;Regulation;Research;research and development;Research Personnel;Resources;Risk;Safety;Seasons;sensor;Severities;skills;social;Sports;Strategic Planning;Structure;success;Surveys;Systems Theory;Testing;therapy development;timeline;Training;Training Programs;Work;Youth

PROJECT_TITLE: Evidence-based intervention for Improved Head Impact Safety in Youth Football

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD-K]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE We must better understand thalamocortical relationships and the role of thalamus, using the somatosensory system as the model, to follow information flow and other aspects of functioning between cortical areas. This fundamental information may be a prerequisite to understanding and better dealing with a number of cognitive defects, like schizophrenia, Alzheimer’s, etc.

PI_NAMEs: MACLEAN, JASON NEIL;SHERMAN, S. MURRAY  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Abbreviations;Acetylcholine;Address;Affect;Alzheimer's Disease;Anatomy;Area;Back;barrel cortex;behavior test;Behavioral;Binding;Biological Models;Brain;Cell Nucleus;Cells;Cognitive deficits;cognitive function;Control Animal;Data;density;Dependovirus;Detection;Discrimination;Dorsal;Electrodes;Electrophysiology (science);Excitatory Postsynaptic Potentials;experimental study;Explosion;Feedback;Fluorescence;Future;gamma-Aminobutyric Acid;Generations;Geniculate body structure;Glutamates;Image;In Vitro;in vivo;interest;Label;Lateral Geniculate Body;Maps;Medial;Metabotropic Glutamate Receptors;Modeling;Monitor;Motor Cortex;Mus;neglect;Nerve;Neurons;Pathway Analysis;Pathway interactions;Pattern;Peripheral;Phase;Physiology;Play;postsynaptic;Preparation;programs;Progress Reports;Property;Pulvinar structure;redshift;Research;response;Role;Route;Schizophrenia;Sensory;sensory cortex;sensory input;Short-Term Memory;Slice;somatosensory;Source;Spinal;Stimulus;Synapses;Synaptic Potentials;System;Tactile;Techniques;Testing;Thalamic Nuclei;Thalamic structure;transmission process;two-photon

PROJECT_TITLE: Thalamocortical interactions

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: Stellenbosch

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: STELLENBOSCH UNIVERSITY

PHR: Project Narrative Rural KwaZulu-Natal, South Africa is considered to be the epicentre of the global HIV epidemic where the level of new HIV infections remains unacceptably high. Utilising one of the largest ongoing HIV cohorts in the world, we will establish the population shift in the pattern of new HIV infections in rural KwaZulu-Natal South Africa (2022-2026). We will quantify the change in the pattern of new HIV infections in the general population following the shift towards Dolutegravir- based regimens (a new cost-effective drug enabling better treatment adherence) as well as the scaling up new of prevention interventions such as the pre-exposure prophylaxis. We will utilize this information to design future combination intervention programs which seek to maximize HIV infection reduction based on the dynamic needs of the most vulnerable sub-populations.

PI_NAMEs: MWAMBI, HENRY GODWELL;TANSER, FRANK COURTENEY (contact)

PROGRAM_OFFICER_NAME: SCOTT-SHELDON, LORI ANN JENNIFER

PROJECT_TERMS: Africa;Africa South of the Sahara;Age;age group;AIDS prevention;antiretroviral therapy;Area;Attitude;Autopsy;Biological;Biological Markers;Blood;care delivery;Cause of Death;Cessation of life;Clinic;Clinical;Clinical Data;cohort;Communities;cost effective;Country;COVID-19 pandemic;Data;data platform;Death Rate;design;Dryness;Early identification;Effectiveness;Elements;Epidemic;Epidemiologic Methods;Epidemiology;Event;Evolution;Exposure to;Funding;Future;future implementation;General Population;genomic data;Goals;Health;Health Services;HIV;HIV Infections;HIV risk;HIV/AIDS;Household;Human immunodeficiency virus test;human old age (65+);Incidence;indexing;Individual;Infection;Infrastructure;Intervention;intervention program;Knowledge;Life Cycle Stages;Link;longitudinal analysis;Measures;Modality;National Institute of Child Health and Human Development;next generation;novel;Paper;Pattern;peri-urban;Persons;Pharmaceutical Preparations;Population;population based;population health;pre-exposure prophylaxis;Prevalence;Prevention;Prevention program;Prevention strategy;preventive intervention;Public Sector;Records;Regimen;Research;Research Institute;Residencies;Resolution;response;Risk;Risk Reduction;Rural;Rural Community;rural South Africa;scale up;Schools;sex;Sex Behavior;sociodemographics;South Africa;South African;Spottings;Statistical Methods;Subgroup;success;surveillance data;Target Populations;Testing;Time;transmission process;treatment adherence;treatment program;Treatment Protocols;United States National Institutes of Health;urban area;Variant;verbal;Viral Load result;Viremia;Vulnerable Populations;Work

PROJECT_TITLE: The changing face of HIV in the era of COVID-19: Maximising HIV incidence reduction through dynamic targeting of current and future distributions of acquisition risk.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-V(02)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Despite the advent of HIV pre-exposure prophylaxis (PrEP), a highly effective HIV biomedical prevention strategy, men who have sex with men (MSM) in the Deep South of the United States continue to face extraordinary rates of new HIV diagnoses. As such, innovative strategies are needed to promote PrEP and increase its uptake and use among those with the greatest need. This project will determine PrEP promotional preferences in order to develop empowering and informative PrEP promotional content that is created by community members.

PI_NAMEs: GRAVETT, RONNIE M (contact)

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: Address;Adherence;Affect;age stratification;AIDS prevention;authority;Award;Awareness;Back;barrier to care;Behavioral Model;black men who have sex with men;Characteristics;collaborative environment;Communities;community engagement;community involvement;crowdsourcing;Data;Dedications;Deep South;design;Development;Development Plans;digital;digital intervention;Disparity;Empathy;empowerment;emtricitabine;Enabling Factors;Epidemic;Ethnic Origin;Evaluation;experimental study;Failure;Future;Goals;Health;Health behavior;health care service utilization;health disparity;Health Services;HIV;HIV diagnosis;homonegativity;Homophobia;human centered design;Human immunodeficiency virus test;Image;improved;innovation;Institutional Racism;Interview;K-Series Research Career Programs;male health;Medical;member;men;men who have sex with men;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;Minority Groups;model design;multidisciplinary;multilevel analysis;Newly Diagnosed;novel strategies;Outcome;Patient-Focused Outcomes;Phase;Physicians;Population;Populations at Risk;pre-exposure prophylaxis;Predisposing Factor;preference;prevent;prevention service;Prevention strategy;Prophylactic treatment;Provider;Race;recruit;Research Personnel;Role;Sampling;Services;sex;Sexual Health;sexual minority;skills;social media;social stigma;Structure;Surveys;systemic barrier;Tablets;Tenofovir;Testing;Text;therapy design;Training;United States;United States National Institutes of Health;uptake;Voice;Work

PROJECT_TITLE: Amplifying Our Voice: Understanding HIV PrEP Promotional Messaging to CreateAuthentic PrEP Content by Men Who Have Sex with Men in the Deep South

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


FUNDING_MECHANISM: OTHERS

ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: Stroke is a leading cause of disability in the U.S. and many Veteran stroke survivors live with severe disability. Despite recent advances in rehabilitation treatments many stroke survivors have persistent physical and mental difficulties such as reduced physical and cognitive function and depression. Developing innovative treatments that address these problems is necessary to improve long-term outcomes for stroke survivors. Aerobic exercise (AEx) can improve physical and cognitive function, and reduce depression. Additionally, AEx may enhance physical rehabilitation by making the brain more receptive to, and consequently improving the response to an intervention. Therefore, combining AEx with physical rehabilitation has the potential to improve multiple aspects of stroke recovery. This study will examine the effect of combining AEx with physical rehabilitation on physical and mental function in stroke survivors. By gaining a better understanding of the effects of this combined intervention we aim to advance the rehabilitative care of Veteran stroke survivors.

PI_NAMEs: ROSS, RYAN  (contact)

PROJECT_TERMS: Address;Adjuvant;Admission activity;Aerobic Exercise;arm function;Award;Behavioral;Biological Markers;Blood specimen;Brain;Brain-Derived Neurotrophic Factor;cardiovascular health;chronic stroke;Cognition;Cognitive;cognitive function;cohort;Coupled;Data;data acquisition;Death Rate;Dedications;depressive symptoms;design;Development;disability;Ducks;effective intervention;Effectiveness;Environment;executive function;Exercise;experience;Exposure to;Fostering;Foundations;functional improvement;Funding;Future;Goals;Health;Impairment;improved;Individual;Infrastructure;innovation;insight;Institution;Intervention;Long term disability;Long-Term Potentiation;Lower Extremity;Measures;Medical;Medical center;Mental Depression;mental function;Mentors;Motor;motor learning;motor rehabilitation;Movement;multidisciplinary;Neurobiology;Neurologic;neurological rehabilitation;Neuronal Plasticity;neuropsychiatry;Outcome;Participant;Patient Self-Report;Physical assessment;Physical Function;Physical Performance;Physical Rehabilitation;Play;Positioning Attribute;post stroke;predicting response;Prevalence;Process;Psyche structure;psychologic;Quality of life;Randomized;rehabilitation paradigm;rehabilitation research;rehabilitation strategy;Rehabilitation therapy;rehabilitative care;Research;Research Personnel;Resources;response;Role;skills;South Carolina;Stretching;Stroke;stroke outcome;stroke recovery;stroke rehabilitation;stroke survivor;Synapses;Therapeutic Intervention;tool;Training;Transcranial magnetic stimulation;Treatment Efficacy;United States;United States National Institutes of Health;Universities;Upper Extremity;Veterans;virtual reality;Work

PROJECT_TITLE: Priming the Rehabilitation Engine: Aerobic Exercise as the Fuel to Spark Behavioral Improvements in Stroke

STUDY_SECTION_NAME: Career Development Program - Panel II[RRD9]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: Narrative: Minority students are underrepresented in PhD programs and in the biomedical workforce in general. The Rush Initiative for Maximizing Student Development (IMSD) provides an innovative and a well-integrated approach to promote PhD completion by underrepresented minority (URM) biomedical students and provides IMSD participants with the tools to place them in a path of success thereafter. The program involves traditional/classical training activities for scientists including training in grant writing and oral presentations and professional development training activities such as time management and conflict resolution, to name a few. These integrated activities will enhance the skills of URM students to develop into productive scientists and professionals so that they complete the PhD program and become equipped with essential tools to navigate a rigorous career in biomedical research.

PI_NAMEs: AL-HARTHI, LENA  (contact);CS-SZABO, GABRIELLA ;SANDI, GISELLE

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Universities

PROJECT_TITLE: IMSD at Rush University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]