ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Social Determinants of Health

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: NARRATIVE The proposed research ethics and methods certificate program will have significant impact in the socio-cultural context of The Gambian people by building leadership and expert capacity. The program will enhance the professional growth of health professionals and academic researchers through the strengthening of competence to conduct health research studies with high ethical standards and scientific rigor. These activities will have long term impact in shaping the scientific enterprise and the culture of ethics in The Gambia to improve population health outcomes.

PI_NAMEs: NJIE-CARR, VERONICA P.S. (contact);SEY-SAWO, JAINABA ;SILVERMAN, HENRY J

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Adult;African;Applications Grants;apprenticeship;Attitude;Award;Awareness;Baltimore;certificate program;cohort;Collaborations;Committee Members;Competence;Consultations;curriculum development;Data Collection;design;Development;Educational Curriculum;Educational process of instructing;Educational Status;Educational workshop;Enrollment;Ensure;Ethics;Ethics Committees;experience;Faculty;falls;Fogarty International Center;Foundations;Funding;Future;Gambia;Ghana;Goals;graduate student;Grant;Growth;Health;Health Professional;Healthcare;Hybrids;improved;Institution;Institutional Review Boards;Knowledge;Leadership;low and middle-income countries;Maryland;member;Mentors;Modeling;Nigerian;Outcome;pedagogy;Performance;Persons;population health;Preparation;Program Development;programs;Qualifying;recruit;Research;Research Ethics;Research Methodology;Research Personnel;research study;response;Review Committee;Role;Shapes;skills;social culture;success;Surveys;Training;Training Programs;Universities;virtual

PROJECT_TITLE: Strengthening Capacity in Health Research Ethics and Methodology in The Gambia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-L(56)R]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Gene Therapy;Genetics;HIV/AIDS;Immunotherapy;Infectious Diseases;Mental Health

ORG_CITY: LOS ANGELES

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Antiretroviral drugs can inhibit HIV infection but cannot eliminate all the infected cells in the body that hide from the immune system. In order to cure HIV, we need to develop methods that accurately quantify the number of infected cells that remain hidden and explore treatments focused around natural killer cells that effectively target these HIV-infected cells. This project has scientific and public health relevance by deepening our understanding of how HIV remains hidden and ultimately uses this knowledge to develop curative strategies that focus around engineering natural killer cells.

PI_NAMEs: BLISH, CATHERINE A;ZACK, JEROME A. (contact)

PROGRAM_OFFICER_NAME: POON, BETTY

PROJECT_TERMS: Ablation;Acquired Immunodeficiency Syndrome;Adverse drug event;Allogenic;analog;Animal Model;Anti-Retroviral Agents;antiretroviral therapy;Bar Codes;bryostatin;Cell Therapy;Cells;Cellular Immunity;Cellular immunotherapy;Charge;chemical synthesis;chimeric antigen receptor;Chronic;Clinical;clinical application;Collaborations;conditioning;cost;cytotoxic;Disease Progression;Disease remission;DNA;efficacy evaluation;engineered NK cell;Engineering;Engraftment;global health;Goals;Hematopoietic Stem Cell Transplantation;HIV;HIV Infections;HIV-1;Human;humanized mouse;Immune;Immune system;Immunity;Immunobiology;improved;In Vitro;in vivo;in vivo evaluation;Individual;Infection;innovation;Interruption;Knowledge;Lead;Libraries;Measures;Medical;Messenger RNA;Methods;Modeling;mouse model;Natural Killer Cell toxicity;Natural Killer Cells;NK cell therapy;novel;Patients;Peripheral;Pharmaceutical Preparations;pressure;Production;Protein Kinase C;Proviruses;public health relevance;receptor;Recrudescences;Regimen;Reporter;research clinical testing;Research Project Grants;response;Rest;T-Lymphocyte;Technology;Testing;Therapeutic;tool;Transfection;Viral;Viral Physiology;viral rebound;Viral reservoir;Viremia;Virus;Virus Activation;Virus Latency;Virus Replication

PROJECT_TITLE: Natural killer cell engineering to target the HIV reservoir


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Depression;Mental Health;Mental Illness;Neurodegenerative;Neurosciences

ORG_CITY: NORTH CHICAGO

ORG_NAME: ROSALIND FRANKLIN UNIV OF MEDICINE & SCI

ORG_STATE: IL

PHR: PROJECT NARRATIVE Anxiety and anatomical sex represent major risk factors for Alzheimer’s disease (AD), with females being more susceptible than males. This K99/R00 proposal will first identify the impact of anxiety and anatomical sex on the neural ensembles mediating memory loss in a mouse model of AD and then use optogenetic techniques to rescue cognitive decline following AD development. Identifying the circuits underlying co-morbid anxiety and cognitive decline in female AD mice will provide the building blocks for specific and personalized therapeutic targets for females suffering from AD.

PI_NAMEs: HUNSBERGER, HOLLY CHRISTIAN (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: 4-Hydroxy-Tamoxifen;Address;Affect;Age;Age Months;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;Amygdaloid structure;Anatomy;Anesthetics;Anxiety;anxiety symptoms;anxiety-like behavior;APP-PS1;Area;Atrophic;Award;Behavior;behavior test;Behavioral;behavioral study;Biological Assay;Brain;Brain imaging;Brain region;Breeding;career;Cause of Death;Cells;Clinical;Clinical Research;Cognitive deficits;cognitive task;comorbid depression;comorbidity;conditioned fear;dentate gyrus;depressive symptoms;design;Development;Diagnosis;Disease;Disease Progression;epidemiology study;Exhibits;experience;Exposure to;Female;Fostering;Genetic;Goals;Hippocampus;Image;Immediate-Early Genes;Impaired cognition;Impairment;in vivo;Individual;interest;Label;Lead;Learning;Link;long term memory;male;Mediating;Memory;memory encoding;Memory impairment;Memory Loss;memory retrieval;Mental Depression;Mental disorders;Mentorship;Microscope;Microscopy;mouse model;Mus;Nerve Degeneration;neural;neural correlate;neural network;Neurodegenerative Disorders;Neurons;neuropsychiatry;novel;optogenetics;Outcome;personalized therapeutic;Population;Predisposition;prevent;processing speed;programs;Reporting;Research;Retrieval;Role;sex;Sex Differences;Short-Term Memory;skills;spatial memory;Symptoms;System;Techniques;Testing;therapeutic evaluation;therapeutic target;Time;Training;Transgenic Organisms;United States;women patients

PROJECT_TITLE: The sex specific impact of anxiety on Alzheimer's disease progression

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Genetics;HIV/AIDS;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Kaposi’s sarcoma-associated herpesvirus (KSHV) has an etiologic role in several human cancers. KSHV infects tumor cells and persists in these cells in a latent state. This work investigates the mechanisms this virus uses to allow it to be maintained in cells since a better understanding of these mechanisms may allow development of strategies which prevent KSHV cancers.

PI_NAMEs: KAYE, KENNETH M (contact)

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Africa South of the Sahara;Anti-viral Response;Biochemical;Biology;Cell division;Cell Nucleus;Cell Proliferation;Cell Survival;Cells;ChIP-seq;Chromatin;Complex;Daughter;Deposition;Development;Disease;DNA amplification;DNA Damage;DNA damage checkpoint;DNA Double Strand Break;DNA Repair;Epidemic;Epigenetic Process;epigenome;Episome;Etiology;Event;experimental study;Failure;gammaherpesvirus;Gene Expression;Gene Silencing;Genes;Genetic;Genetic Transcription;Genome;Growth;Herpesviridae;Herpesviridae Infections;Human;Human Herpesvirus 8;Immunocompromised Host;in vivo;Individual;Infection;insight;Kaposi Sarcoma;Knockout Mice;latency-associated nuclear antigen;latent infection;Link;Lytic;lytic gene expression;Lytic Phase;lytic replication;Maintenance;Malignant Neoplasms;Mediator;Modeling;Modification;Multicentric Angiofollicular Lymphoid Hyperplasia;Mus;Nature;neoplastic cell;novel;Oral cavity;Organ;Polycomb;prevent;primary effusion lymphoma;Process;Proliferating;promoter;Proteins;Quality Control;recruit;repaired;response;Role;Saliva;segregation;Site;Stimulus;Transcriptional Activation;Transcriptional Regulation;transmission process;tumor;ubiquitin-protein ligase;Viral;Viral Genes;Viral Genome;Virus;Virus Latency;Visceral;Work

PROJECT_TITLE: KSHV Latent Infection Replication


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Cancer;Liver Disease;Prevention;Rare Diseases

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: PROJECT NARRATIVE The one-carbon metabolism pathway plays a plausible role in the development of hepatocellular carcinoma (HCC) in persons with non-alcoholic fatty liver disease (NAFLD). This proposal is designed to test the hypotheses that (1) inherited genetic variants, (2) acquired modifications to DNA, and (3) metabolic molecules of the one-carbon pathway play significant roles in HCC development in persons with NAFLD. Findings from this research are expected to improve strategies for prevention, risk assessment and stratification, and early detection of HCC, an often fatal cancer.

PI_NAMEs: ANTWI, SAMUEL O. (contact)

PROGRAM_OFFICER_NAME: VAHEDI, SHAHROOZ

PROJECT_TERMS: Alcohol abuse;Alcoholic Hepatitis;Anabolism;Animals;Biochemical;Bioinformatics;Candidate Disease Gene;Carbon;career development;Choline;Chronic Hepatitis B;Clinical;Competence;Cytosine;Data;design;Development;Diagnosis;Discipline;disorder control;DNA;DNA Methylation;DNA Modification Methylases;Early Diagnosis;Educational workshop;Enzymes;Epigenetic Process;epigenetic variation;Folic Acid;Fostering;Gene Expression Regulation;Genes;Genetic;genetic epidemiology;Genetic Risk;genetic variant;Genetic Variation;Goals;Hepatic;Hepatitis C;Human;Impairment;improved;Incidence;indexing;Individual Differences;Infection;Inherited;inhibitor;insight;Liver;Liver Cell Adenoma;loss of function mutation;Malignant Neoplasms;member;Mentors;Metabolic;Metabolism;metabolomics;Methionine;methyl group;Methylation;Modification;Molecular Epidemiology;mortality;mouse model;non-alcoholic fatty liver disease;novel;Nutrient;Pathway interactions;Patients;Persons;Play;Predisposition;Prevention;Prevention strategy;Primary carcinoma of the liver cells;Primary Malignant Neoplasm of Liver;programs;Recording of previous events;Research;Risk;Risk Assessment;risk stratification;risk variant;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;Signal Transduction;skills;Structure;Testing;Variant;Viral hepatitis

PROJECT_TITLE: Integrated molecular epidemiologic analysis of the one-carbon metabolism pathway and risk of HCC

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

PHR: NARRATIVE Epstein-Barr virus (EBV) causes infectious mononucleosis, lymphoma, nasopharyngeal gastric carcinomas and in HIV/AIDS patients oral hairy leukoplakia. These studies will increase understanding of how EBV subverts a key cellular pathway that senses and counteracts viral DNA genomes, which may lead to novel therapeutic approaches.

PI_NAMEs: GEWURZ, BENJAMIN ELISON (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: 3-Dimensional;Acquired Immunodeficiency Syndrome;Address;Adult;ATAC-seq;B-Lymphocytes;Binding;Cell Compartmentation;cell growth;Cell Nucleus;Cell Survival;cell transformation;Cells;ChIP-seq;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Co-Immunoprecipitations;co-infection;cohesin;Complex;Cullin Proteins;DNA;DNA Binding Domain;DNA biosynthesis;DNA Structure;Double Stranded DNA Virus;ds-DNA;Epigenetic Process;Episome;Epithelium;Epstein-Barr Virus latency;Gene Expression;Genetic study;Genome;Genomic Segment;Hairy Leukoplakia;HIV;HIV/AIDS;Hour;Human;Human Herpesvirus 4;Infection;Infectious Mononucleosis;insight;Integration Host Factors;Knock-out;Learning;Ligase;Lymphoma;Lytic;lytic replication;Lytic Virus;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Membrane;Molecular;Nasopharynx;novel therapeutic intervention;Oral cavity;Pathway interactions;Patients;Persons;Phase;programs;Proteins;Proteomics;Regulation;Role;Saliva;Series;Site;Stomach Carcinoma;Testing;Tonsil;transcriptome sequencing;transmission process;ubiquitin ligase;Viral;viral DNA;Viral Genes;Viral Genome;viral genomics;Viral Load result;virtual;Virus;Virus Replication

PROJECT_TITLE: Characterization of Epstein-Barr Virus Subversion of the Host SMC5/6 Restriction Pathway

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-S(90)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Genetics;Pediatric

ORG_CITY: Nashville

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative The goal of this study is to investigate how a family of myelin transcription factors regulates islet beta cell function and survival. The significance is that humans need to maintain fully functional beta cells to avoid debilitating hypoglycemia or diabetes. We expect to uncover basic molecular and cellular mechanisms to help improve the regulation of this mass to avoid these diseases.

PI_NAMEs: GU, GUOQIANG  (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: 5' Flanking Region;Adult;Affect;Anabolism;Apoptotic;ATF6 gene;Attenuated;Beta Cell;biological adaptation to stress;blood glucose regulation;Cell Death;Cell Line;Cell Physiology;Cell Proliferation;Cell Survival;Cell Transplantation;Cells;Cessation of life;ChIP-seq;Compensation;Complex;derepression;Development;Diabetes Mellitus;Disease;Down-Regulation;Failure;Family;Functional disorder;gain of function;Gene Activation;Gene Expression;gene product;gene repression;Genes;Genetic Transcription;Glucose;Glucose Intolerance;glucose metabolism;Goals;Heat-Shock Response;Histone Deacetylase;Histone Deacetylation;Histones;Homeostasis;Human;Hyperglycemia;Hypoglycemia;Immunodeficient Mouse;improved;In Vitro;in vivo;in vivo evaluation;Insulin;Insulin Resistance;insulin secretion;Interruption;islet;Islet Cell;islet stem cells;Islets of Langerhans;knock-down;Knowledge;Lead;Link;loss of function;Mediating;Messenger RNA;Metabolic;Metabolic stress;Mitochondria;Modeling;Molecular;Molecular Target;Mus;Myelin;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Open Reading Frames;Output;Oxidative Stress;paralogous gene;Peripheral;Persons;Physiology;postnatal;prevent;Process;Production;Proinsulin;Proteins;Proteomics;Publishing;Reactive Oxygen Species;recruit;Regulation;Repression;response;Role;Stress;stressor;Structure of beta Cell of islet;Testing;Tissues;transcription factor;transcriptome sequencing;Translations;Up-Regulation;Workload

PROJECT_TITLE: Regulating stress response to promote postnatal beta-cell function and survival

STUDY_SECTION: CADO

STUDY_SECTION_NAME: Cellular Aspects of Diabetes and Obesity Study Section[CADO]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE Here we investigate a synthetic noncoding RNA molecule, TY4, bioinspired by the contents of extracellular vesicles. Preliminary data indicate TY4 is cardioprotective when administered orally or intravenously after ischemia/reperfusion. The studies will advance our mechanistic understanding of cardioprotection, while constituting an important translational step towards the development of a novel, orally-bioavailable agent adjunctive to reperfusion therapy for myocardial infarction.

PI_NAMEs: MARBAN, EDUARDO  (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Acute myocardial infarction;Adoptive Transfer;Antisense Oligonucleotides;aptamer;Attention;Binding;Biodistribution;Biological;Biological Availability;cardioprotection;Cardiotonic Agents;Caseins;Cell Nucleus;Cell Survival;Cell Therapy;Cells;Chemicals;Chronic;cytokine;Data;Development;Dichloromethylene Diphosphonate;Disease;dosage;Duchenne muscular dystrophy;EFRAC;exosome;extracellular vesicles;FDA approved;Gatekeeping;Gene Expression;Genes;Heart;Heart Diseases;Heart failure;Human Milk;In Vitro;in vivo;Infarction;Inflammatory;Injury;insight;Interleukin-10;Intravenous;Ischemia;Left;Link;Macrophage;Measures;Mediating;Mediator;Messenger RNA;Milk Proteins;Modeling;mouse model;Mus;mutant;Myocardial Infarction;Necrosis;new chemical entity;novel;Nuclear Pore Complex Proteins;Nucleotides;old mice;Oral;Oral Administration;Outcome;paracrine;Pathway interactions;Peptides;Pharmaceutical Preparations;preservation;Property;prototype;Rationalization;regenerative cell;regenerative therapy;Reperfusion Therapy;RNA;Role;Small Interfering RNA;Testing;Thinking;Tissues;transcriptomics;translational potential;Transplantation;Untranslated RNA;Work

PROJECT_TITLE: Cardioprotective mechanisms of novel noncoding RNA in myocardial infarction

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Genetics;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Little is known regarding the etiology of mitral valve prolapse (MVP), one of the most common diseases, affecting 1 in 40 individuals. Uncovering the genetic causes for this disease will provide key insight into mechanisms that contribute to valve development and allow us to study why MVP happens. Based on our genetic, developmental and molecular discoveries, our goal for this proposal is to examine new mechanisms for valvular development and their link to the pathogenesis of cardiac valve diseases.

PI_NAMEs: NORRIS, RUSSELL  (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: 17p13;3-Dimensional;Affect;Arrhythmia;Back;Biochemical;Biological;Biological Models;Biology;Biomechanics;Biomedical Engineering;Cardiac;cardiogenesis;Cells;Chromatin;Cilia;cilium biogenesis;Clinical;Code;Collagen;Congestive Heart Failure;Connexin 43;Data;Defect;Deposition;Development;Disease;Endocarditis;Enhancers;Etiology;Event;Evolution;Extracellular Matrix;Extracellular Matrix Proteins;Failure;Fibroblasts;fibrogenesis;functional genomics;Funding;Future;General Population;Genes;Genetic;genetic approach;Genetic study;genome wide association study;Goals;Grant;Heart Atrium;Heart failure;Heart Valve Diseases;Heart Valves;Human;Hyperplasia;Individual;insight;interstitial cell;Light;Link;Marfan Syndrome;Mechanical Stress;Mechanics;Medial;Mesenchymal;Mesenchyme;Mitral Valve;Mitral Valve Insufficiency;Mitral Valve Prolapse;Modeling;Molecular;Mus;mutant;Mutation;Natural regeneration;novel;Operative Surgical Procedures;Pathogenesis;Pathway interactions;patient population;Patients;Phenotype;Play;Population;premature;Process;Production;Proteins;Proteoglycan;Ptosis;repaired;Research;RNA Splicing;Role;stem;Stress;Structure;Structure of chordae tendineae cordis;sudden cardiac death;Sudden Death;Syndrome;Systole;Testing;Therapeutic;Time;Tissues;Transcription Initiation Site;Ventricular;Work

PROJECT_TITLE: Cilia and Valvular Heart Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-C(02)]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE With repeated opioid use, a driving factor for drug taking becomes the desire to avoid the aversive state of withdrawal, instead of the acute rewarding effects of the drug. However, it is not clear how chronic opioid use alters neural circuits involved in aversion processing to initiate and sustain this aversive withdrawal state. The goal of this project is to understand how chronic opioid use induces plasticity in brain circuits involved in aversion processing, and how these changes drive the aversive state of opioid withdrawal; outcomes of this project will ultimately inform targeted therapies in the treatment of drug withdrawal.

PI_NAMEs: TOOLEY, JESSICA  (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Abstinence;Acute;Affective Symptoms;allostasis;American;AMPA Receptors;Anhedonia;Appetitive Behavior;Area;Automobile Driving;Aversive Stimulus;Behavior;Behavioral;Behavioral Assay;Brain;cell type;Cells;Chronic;Coupled;Cues;Data;Disease;Drug abuse;drug withdrawal;Electrophysiology (science);Emotional;Event;exhaust;Exhibits;experimental study;Functional disorder;Future;Globus Pallidus;Glutamates;Goals;GTP-Binding Proteins;Habenula;Height;Hyperactivity;in vivo;Intake;Lateral;Longitudinal Studies;Measures;Mediating;mu opioid receptors;Mus;N-Methyl-D-Aspartate Receptors;Nature;negative affect;Negative Valence;neural circuit;neuromechanism;Neurons;Opioid;opioid misuse;opioid use;opioid use disorder;opioid withdrawal;optogenetics;Oral;Outcome;Output;Oxycodone;oxycodone self-administration;Pain;patch clamp;Pattern;Persons;Pharmaceutical Preparations;pharmacologic;Population;Positioning Attribute;Positive Valence;postsynaptic;prescription opioid;Prevention strategy;Probability;Property;Public Health;Punishment;recruit;Relapse;relapse risk;response;reward processing;Rewards;Risk Behaviors;Role;Self Administration;Stimulus;Stress;Structure;Substance abuse problem;Synapses;targeted treatment;Techniques;Testing;Therapeutic Intervention;transmission process;treatment strategy;Withdrawal;Withdrawal Symptom;Work

PROJECT_TITLE: Dissecting the contribution of glutamatergic ventral pallidal neurons to the aversive state of opioid withdrawal


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: SEATTLE

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Understanding new roles for natural reward circuitry is a vital first step to understand the reward circuitry perturbed in addiction. This project aims to understand how discrete environmental cues integrate with natural rewards to change their subjective value. This can serve to explain why reward seeking is enhanced and persistent in certain environments, as occurs during drug addiction and relapse.

PI_NAMEs: HJORT, MADELYN  (contact)

PROGRAM_OFFICER_NAME: BABECKI, BETH

PROJECT_TERMS: Acceleration;addiction;Address;Animals;Area;Association Learning;Behavior;Behavioral;Brain;Calcium;Cells;Classification;Consumption;Cues;Desire for food;Drug Addiction;drug relapse;Elements;Environment;Food;Future;Goals;Head;hippocampal pyramidal neuron;Human;Image;in vivo;indexing;Individual;Learning;lens;Link;Machine Learning;multimodality;multisensory;Mus;neural circuit;Neurobiology;Neurons;novel;Odors;olfactory stimulus;optogenetics;orofacial;paired stimuli;Pathologic;Perception;Pharmaceutical Preparations;Process;Relapse;Reporting;reward circuitry;Rewards;Role;Sensory;sensory cortex;sensory input;sensory integration;sensory stimulus;Site;Smell Perception;Stimulus;supervised learning;Taste Perception;Techniques;Testing;Time;Training;two-photon;Visualization

PROJECT_TITLE: Multimodal Sensory Integration in Orbitofrontal Cortex during Natural Reward Seeking


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Headaches;Migraine;Neurosciences;Opioids;Pain Research

PHR: Overuse of medications commonly prescribed for headache management can result in a contradictory increase in pain sensitivity, known as medication overuse headache. Our lab has identified two novel targets that block this medication exaggerated pain – the delta opioid receptor and the PACAP-PAC1 receptor. The aim of this proposal is to determine if these two targets commonly interact to inhibit medication overuse headache.

PI_NAMEs: PRADHAN, AMYNAH AMIR ALI (contact)

PROGRAM_OFFICER_NAME: OSHINSKY, MICHAEL L

PROJECT_TERMS: Absence of pain sensation;Abstinence;abuse liability;Acute;Adenylate Cyclase;Affect;Agonist;allodynia;Analgesic Overuse Headaches;associated symptom;Auras;Behavioral;Binding;Biochemical;Biological Assay;Brain region;Cells;Cephalic;Chronic;chronic pain;Clinical;Clinical Trials;Complex;conditional knockout;Data;delta opioid receptor;disability;Disease;drug development;Effectiveness;efficacy evaluation;Electrophysiology (science);Emotional;evidence base;experimental study;Funding;gamma-Aminobutyric Acid;Genetic;Goals;Grant;GTP-Binding Proteins;Headache;Headache Disorders;Hot Spot;Immunohistochemistry;In Situ Hybridization;Individual;inhibitor;innovation;insight;interdisciplinary approach;Knock-out;Link;Maps;midbrain central gray substance;Migraine;migraine treatment;Modeling;novel;novel therapeutic intervention;Opioid;Opioid agonist;Opioid Receptor;PACAPR-1 protein;Pain;pain processing;pain sensitivity;Patients;Peripheral;Pharmaceutical Preparations;Pharmacotherapy;pituitary adenylate cyclase activating polypeptide;Population;Post-Traumatic Headaches;presynaptic;Prevalence;Quality of life;receptor;Receptor Activation;receptor expression;Refractory;return to use;Role;Severities;Signal Transduction;Site;Source;Structure of trigeminal ganglion;System;targeted treatment;Testing;Therapeutic;therapeutic target;translational model;Trigeminal Nuclei;Trigeminal System;triptans;Viral;Work

PROJECT_TITLE: The role of delta opioid receptors in trigeminovascular pain


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: NEWARK

ORG_DEPT: BIOLOGY

ORG_NAME: RUTGERS THE STATE UNIV OF NJ NEWARK

ORG_STATE: NJ

PHR: Traumatic brain injury causes damage and functional deficits associated with the site of injury, but also can affect afferent neurons that project to the injured regions from distal locations, affecting their ability to function properly and possibly causing them to degenerate. Basal forebrain cholinergic neurons, which project throughout the cortex, play a major role in many cognitive functions and are particularly vulnerable to degeneration in Alzheimer’s disease and other cognitive impairments. To understand the full scope of damage resulting from TBI, and to develop therapeutic approaches to minimize the consequences of the brain injury, we will investigate how damage to the cortex affects afferent neurons that project to the injured target, and whether they undergo degenerative changes as a consequence of the injury.

PI_NAMEs: FRIEDMAN, WILMA J (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Affect;Afferent Neurons;Alzheimer's Disease;Apoptosis;Apoptotic;Area;Axon;axon growth;axonal degeneration;basal forebrain;basal forebrain cholinergic neurons;Behavioral;Brain;Brain Injuries;Brain region;Cells;Characteristics;cognitive function;cytokine;Data;Dependence;Development;Distal;Environment;Exposure to;Family;fluid percussion injury;Functional disorder;Growth Factor;Hippocampus;Impaired cognition;In Vitro;Inflammatory;injured;Injury;insight;Learning;Life;Location;Maintenance;Mediating;Memory;millimeter;Modeling;Mus;Nerve Degeneration;Nerve Growth Factor Receptors;neural circuit;Neurodegenerative Disorders;neuron apoptosis;neuron loss;neuronal survival;Neurons;neurotransmission;neurotrophic factor;NGFR Protein;Pathway interactions;Play;polarized cell;Presynaptic Terminals;Process;Production;Protein Biosynthesis;Proteins;Proteomics;receptor;Receptor Protein-Tyrosine Kinases;Receptor Signaling;Regulation;response;Retrograde Degeneration;Role;Signal Transduction;Site;Therapeutic;therapeutic target;Time;Tissues;Traumatic Brain Injury

PROJECT_TITLE: TBI leads to degeneration of afferent neuronal projections

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Digestive Diseases;Neurosciences;Nutrition;Obesity

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative The main objective of the proposed research career development plan is to facilitate the applicant's transition to a fully independent academic scientist investigating the contribution of the locus coeruleus to feeding and illness- like behaviors. Proposed research will identify the mechanisms by which glucagon-like peptide-1 signals in the locus coeruleus to suppress food intake and will advance our understanding of how the brain controls feeding behavior and a potential target for obesity pharmacotherapies.

PI_NAMEs: FORTIN, SAMANTHA  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Affect;Agonist;analog;Anatomy;Anorexia;antagonist;Anti-Obesity Agents;Behavior;Behavior Therapy;Behavioral;Behavioral Mechanisms;behavioral pharmacology;Bioinformatics;Body Weight;Body Weight decreased;Brain;brain control;Calcium Signaling;career development;Cell Nucleus;clay;combat;Complex;Computer software;Data;Dedications;Development;Development Plans;Eating;Economics;Electrophysiology (science);Emetics;exenatide;experimental study;FDA approved;feeding;Feeding behaviors;Fingerprint;Funding;Future;Genes;Genetic;GLP-I receptor;glucagon-like peptide 1;glutamatergic signaling;Glutamates;Goals;hindbrain;Human;human model;improved;In Situ Hybridization;in vivo calcium imaging;Individual;Ingestion;insight;integrated circuit;Investigation;Kaolin;knock-down;Ligands;locus ceruleus structure;Mediating;Microinjections;Mus;Nature;Nausea;Nausea and Vomiting;neural;Neuroanatomy;Neurons;noradrenergic;Norepinephrine;novel;Obesity;Obesity Epidemic;obesity treatment;Output;parabrachial nucleus;Pathway interactions;Pattern;Peripheral;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Physiological;Pica Disease;Population;Pre-Clinical Model;preproglucagons;presynaptic;Presynaptic Terminals;Prevalence;professor;Proxy;Public Health;Rattus;Receptor Activation;Receptor Signaling;reduced food intake;Regulation;Reporting;Research;response;RNA Interference;Role;Satiation;Scientist;Shrews;Sick Role;side effect;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;Site;skills;Source;success;tenure track;Testing;Therapeutic;Therapeutic Effect;Time;Training;transcriptome;transcriptomics;translational approach;Virus;Vomiting

PROJECT_TITLE: Examining the role of locus coeruleus glucagon-like peptide-1 receptors in feeding behavior

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Project Narrative The Hippo pathway is an evolutionarily conserved developmental pathway that controls organ size and tissue homeostasis in all metazoan animals. Dysregulated Hippo pathway has been implicated in a wide range of human disorders, including cancer. Despite the well-established Hippo pathway core signaling cascade, the upstream regulation of the Hippo pathway is less understood. This proposal aims to provide novel mechanistic understanding of how Hippo pathway upstream signals are coordinated.

PI_NAMEs: YU, JIANZHONG  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Actins;Animals;Apical;Apoptosis;Binding;Biochemical;Cell Differentiation process;Cell Physiology;Cell Proliferation;Cells;Charcot-Marie-Tooth Disease;Cytoskeleton;Defect;Development;Disease;Drosophila genus;Exhibits;F-Actin;Family;fly;Genes;Genetic;Genetic Transcription;Goals;Growth;Homeostasis;Human;imaginal disc;inorganic phosphate;insight;Lipids;Malignant Neoplasms;Mediating;member;Membrane;Membrane Lipids;mutant;Mutation;myotubularin;Neurofibromin 2;novel;Oncoproteins;Organ Size;overexpression;Pathway interactions;Phenotype;phosphatidylinositol 3-phosphate;Phosphatidylinositols;Phospholipids;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physiological;Production;Proteins;Regulation;Role;Signal Pathway;Signal Transduction;Testing;Tissues;Tumor Suppressor Proteins;Work

PROJECT_TITLE: Upstream regulation of the Hippo signaling pathway

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Aging;Brain Disorders;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: Relevance to Public Health White matter ischemia causes sensory and motor impairments and dementia. A limited process of recovery occurs in other, non-ischemic forms of white matter injury, such as in multiple sclerosis but there is no information as to whether neural repair occurs in white matter ischemia. This grant identifies cellular and molecular mechanisms of white matter repair in white matter ischemia.

PI_NAMEs: CARMICHAEL, STANLEY THOMAS (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Acceleration;Age;age effect;age related;Alzheimer's disease pathology;Behavioral;Bioinformatics;Biological Markers;Blood - brain barrier anatomy;Brain;Brain region;Calcium;Candidate Disease Gene;Cell Physiology;Cerebrum;Data;Dementia;DIF factor;Diffuse;Diffusion;Disease;Focal Neurologic Deficits;gain of function;Gene Expression Profiling;Genes;Goals;Grant;Human;hypoperfusion;Image;imaging biomarker;In Vitro;in vivo;Inflammatory;innovation;Ischemia;Label;loss of function;Magnetic Resonance Imaging;Maps;Mediating;Modeling;Molecular;Molecular Target;motor impairment;mouse model;Multiple Sclerosis;Mus;neural initiation;neural repair;Neurons;new therapeutic target;novel;old mice;oligodendrocyte progenitor;optogenetics;Outcome;Pathology;Pre-Clinical Model;preclinical study;precursor cell;Process;Proliferating;Public Health;Recovery;regenerative;repaired;Reporter Genes;response;Rest;Role;Sensory impairment;Stroke;Structure;System;technology platform;Testing;Transgenic Organisms;Vascular Diseases;Viral;white matter;White Matter Disease;White Matter Hyperintensity;white matter injury;Work

PROJECT_TITLE: Mechanisms of White Matter Repair in Subcortical White Matter Ischemia

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

PHR: Traumatic Brain Injury (TBI) is a major cause of death and disability among both civilians and military personnel, with about 1.4 million TBI’s occurring each year in the U.S. For military personnel, between 14-20% of surviving casualties had a TBI. Studies proposed investigate chronic effects of closed head brain injury, including cognitive decline and early-onset dementia. This work may lead to a new strategy for improving chronic outcomes after TBI.

PI_NAMEs: TOMLINSON, STEPHEN  (contact)

PROJECT_TERMS: 3xTg-AD mouse;Acceleration;AD transgenic mice;Address;Adult;Affect;Affective;Age;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Anatomy;animal data;Animal Model;Behavioral;behavioral outcome;Brain;Brain Injuries;burden of illness;Cause of Death;CD11c Antigens;Cells;Cerebrum;Characteristics;Chronic;Chronic Phase;Clinical;clinically relevant;Closed head injuries;Cognitive;Cognitive deficits;Complement;Complement 3d Receptors;Complement Activation;complement system;Data;Dementia;dementia risk;disability;Disease;early onset;Environmental Risk Factor;Event;executive function;experience;Failure;Female;follow-up;Genetic Transcription;Goals;Growth Factor;Head;high risk;hyperphosphorylated tau;imaging study;Immunologics;Impaired cognition;Impairment;improved;Infiltration;inhibitor;Injury;Internal Ribosome Entry Site;Intervention;ITGAM gene;ITGB2 gene;Knockout Mice;Knowledge;Limbic System;Link;long-term sequelae;Longitudinal Studies;Macrophage-1 Antigen;Magnetic Resonance Imaging;male;Measures;Mediating;Microglia;Military Personnel;Modeling;mouse model;Mus;Nerve Degeneration;neurobehavioral;neurobehavioral test;Neurofibrillary Tangles;neuroinflammation;Neuronal Plasticity;Neurons;Outcome;Pathologic;Pathology;Performance;Phagocytosis;Population;post intervention;prevent;Process;Production;receptor;Reporter;response;Risk Factors;Role;Schedule;Serum;Signal Transduction;Site;Source;Synapses;Synaptic plasticity;System;tau aggregation;Tauopathies;Testing;Therapeutic;Tomatoes;Transgenic Mice;translational approach;Traumatic Brain Injury;Treatment Protocols;treatment strategy;Veterans;Wild Type Mouse;Work

PROJECT_TITLE: The role of complement in chronic neuroinflammation and cognitive decline after closed head brain injury

STUDY_SECTION_NAME: Brain Health and Injury[RRD1]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Patient Safety;Prevention

ORG_CITY: PRINCETON

ORG_NAME: NOVAFLUX, INC.

PHR: 8. Project Narrative  This project is directed to developing a novel skin-safe hand wash product that will significantly decrease the C. difficile spore levels on hands (>3.5 log reduction) compared to traditional soap and water hand wash which is marginally effective (1-2 log reduction), and to alcohol based hand sanitizers which are entirely ineffective. The anticipated product is based on a new class of microstructured fluid that is highly functional in removing spores and pathogens from skin by a cardinally new mechanism of action. The product is expected to provide a robust solution to prevent transmission of C. difficile and hospital-acquired infections (HAI) in healthcare and community facilities, with additional potential applications in patient bathing and skin treatment.

PI_NAMEs: LABIB, MOHAMED E (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Adopted;Adult;Alcohol consumption;Alcohols;Bathing;Caring;Cellulose;Cessation of life;Clostridium difficile;Communities;Developed Countries;Development;Diarrhea;Disease Outbreaks;Epidemic;Excision;experience;Family suidae;Formulation;Goals;Hand;Handwashing;Health Care Costs;health care settings;Health Personnel;Healthcare;Hospitals;Human Resources;Hygiene;improved;Incidence;Industry;Infection;Infectious Agent;Infectious Skin Diseases;Ingestion;innovation;Liquid substance;manufacture;Marketing;Mechanics;Medical center;Methods;Modeling;Norovirus;Nosocomial Infections;novel;Organism;pathogen;Patients;Performance;Persons;Phase;Physicians;prevent;Prevention;Quality Control;randomized trial;Reproduction spores;Resistance;Safety;safety testing;Scientist;shear stress;skills;Skin;Soaps;Structure;Surface;Testing;transmission process;United States;Virion;Water

PROJECT_TITLE: Novel hand hygiene product to remove Clostridioides difficile spores

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-V(13)]


NIH_SPENDING_CATS: Genetics

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Project Narrative This proposal explores three major aspects of synthetic biology- all related to the evolution of life: a look forward into evolution by creating organisms with an expanded genetic code, and a look back into evolution by exploring the evolution of mitochondria in a well-defined “synthetic” system, and by exploring one possible mechanism for the transition from the RNA to DNA world through the generation of bacteria with chimeric DNA-RNA genomes.

PI_NAMEs: SCHULTZ, PETER G (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Amino Acids;Back;Bacteria;Bacterial DNA;Biology;Cell Wall;Chemistry;DNA;endosymbiont;Evolution;Generations;Genes;Genetic Code;Genome;Life;Metabolic;Mitochondria;Organism;protein folding;Ribonucleotides;RNA;synthetic biology;System;tool

PROJECT_TITLE: Synthesis at the Interface of Chemistry and Biology


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Project Narrative The role of mitochondrial type 1 ryanodine receptor in the regulation of cardiac function and energetics during the progression of cardiac hypertrophy and heart failure remains unknown. This proposal intends to fill this knowledge gap by using several mouse models to gain mechanistic insights into its regulatory role in cardiac function under healthy and failing heart. The findings from the proposed studies will provide novel insight for developing new therapeutic strategy to ameliorate cardiac hypertrophy and heart failure.

PI_NAMEs: SHEU, SHEY-SHING  (contact);WANG, YONG-XIAO ;ZHENG, YUN-MIN

PROJECT_TERMS: Accounting;Animals;aorta constriction;Arrhythmia;Bioenergetics;Cardiac;Cardiac Myocytes;Cell Death;Cells;Cessation of life;Chronic;Citric Acid Cycle;Compensation;Coupled;Coupling;Dantrolene;Data;Defect;Development;effective therapy;Electron Transport Complex III;Endothelin-1;energy balance;Energy consumption;Enzymes;Frequencies;Functional disorder;Generations;Genetic;Heart;Heart failure;heart function;Heart Hypertrophy;Human;In Vitro;in vivo;inhibitor;Injury;innovation;Inositol;insight;Iron;ITPR1 gene;Knock-out;Knockout Mice;Knowledge;Lead;Malignant hyperpyrexia due to anesthesia;Mediating;Mitochondria;mitochondrial dysfunction;mitochondrial permeability transition pore;Molecular;mortality;mouse model;Mus;Muscle Cells;Natural regeneration;novel;novel therapeutic intervention;Organ;Outcomes Research;overexpression;Oxidative Stress;Paper;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Phenotype;Physiological;Physiology;Play;Process;Production;Proteins;Publishing;Pump;receptor;Regulation;Reporting;Research;Rieske iron-sulfur protein;Role;Ryanodine Receptor Calcium Release Channel;RyR2;Sarcoplasmic Reticulum;Signal Transduction;Stimulus;Stress;Sulfur;Therapeutic;Thoracic aorta;Tissue Sample;tool;tripolyphosphate;Up-Regulation;uptake

PROJECT_TITLE: Crosstalk Ca2+ Signaling between Ryanodine Receptors Type 1 and 2 in the Pathogenesis of Cardiac Hypertrophy and Heart Failure

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: The goal of this proposed research is to leverage unique features of a new animal model to study fundamental principles of neural systems, the integration of newborn neurons into functioning networks, and regeneration following injury. With this tiny, transparent organism, it is possible to examine cell migration, axon outgrowth and retraction, and the functional activity of the entire network simultaneously across the whole organism, in vivo, using genetically encoded optical techniques. Moving forward, these high-resolution studies will generate new theories and approaches towards understanding how nervous systems generate animal behavior, mechanisms linking neurogenesis to system function, and insights into novel regenerative capabilities.

PI_NAMEs: WEISSBOURD, BRANDON  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Ablation;Action Potentials;analytical tool;Animal Behavior;Animal Model;Animals;arginylphenylalaninamide;Axon;Bacteria;Behavior;Behavioral;Biological;Biological Models;Biological Process;Biology;biomarker identification;Body part;calcium indicator;cell motility;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Complex;coping;Cues;Data;Development;Developmental Process;Disease;DNA;Food;Foundations;Future;Gene Transfer Techniques;Genetic;Genetic Models;Genetic Techniques;Goals;Grant;healing;Health;Human;Image;in vivo;Injury;innovation;insight;Investigation;Jellyfish;Knock-in;Knock-out;Knowledge;life span;Link;Maps;Measures;migration;millisecond;model organism;Modeling;Modernization;Molecular;molecular phenotype;Natural regeneration;Nerve Regeneration;Nervous System;Nervous System Physiology;neural;neurodevelopment;neurogenesis;neuromechanism;Neurons;Neuropeptides;neuroregulation;Neurosciences;newborn neuron;novel;Nuclear Import;Numeric Rating Scale;Optics;optogenetics;Oral cavity;Organism;Peptides;Pharmaceutical Preparations;Physiology;Population;Positioning Attribute;Postdoctoral Fellow;programs;Property;Publishing;Reagent;Recovery;regeneration following injury;regenerative;Research;Resolution;RFamide peptide;Role;Science;single-cell RNA sequencing;Sodium;Structure;System;Techniques;Testing;theories;Training;Transgenic Organisms;Vision;Whole Organism;Work

PROJECT_TITLE: A New Animal Model to Examine Nervous System Function Development and Regeneration

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Childhood Injury;Eye Disease and Disorders of Vision;Hydrocephalus;Neurosciences;Orphan Drug;Pediatric;Physical Injury - Accidents and Adverse Effects;Rare Diseases;Stroke;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative Children with hydrocephalus need timely surgical diversion of the excess cerebrospinal fluid to prevent permanent brain damage. Successful surgical intervention must be guided by precise biomarkers of brain health. This proposal advances ocular microcirculation as assessed using contrast-enhanced ultrasound as a biomarker of intracranial pressure and brain ischemia in pediatric hydrocephalus.

PI_NAMEs: HWANG, MISUN  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: 3-Dimensional;Acoustics;Adopted;Affect;Age;Algorithms;Assessment tool;Biological Markers;biomarker development;Blood flow;Blood Vessels;Brain;brain health;Brain Injuries;Brain Ischemia;Calibration;Caring;Cerebral Ventricles;Cerebrospinal Fluid;Child;Childhood;Clinical;clinical translation;Clinical Trials;Compensation;Complex;contrast enhanced;Contrast Media;Death Rate;Doppler Ultrasound;Erythrocytes;Evaluation;experience;Eye;Eye diseases;Eye Movements;Family suidae;FDA approved;Goals;hemodynamics;Hemorrhage;Histologic;Histopathology;Hydrocephalus;hypoxic ischemic injury;Image;in vivo;indexing;Infant;Infection;insight;International;Intracranial Hypertension;Intracranial Pressure;Intravenous;Investigational Drugs;Ischemia;Label;Lesion;Liquid substance;Liver;Location;Maps;Measures;Mechanics;Mediating;meter;Methods;Microbubbles;Microcirculation;Microdialysis;Modeling;Monitor;Motion;multidisciplinary;Necrotizing Enterocolitis;Nervous System Disorder;neuropathology;non-invasive monitor;novel;Ocular Pathology;Operative Surgical Procedures;Ophthalmologist;Ophthalmology;Optical Methods;Optics;Outcome;particle;Pathology;Patients;Peripheral;phantom model;porcine model;Preparation;Prevalence;prevent;Procedures;prognostication;Protocols documentation;Reproducibility;Retina;Risk;Safety;Shunt Device;spatiotemporal;Speed;statistics;Structure of fontanel of skull;System;Techniques;Technology;therapeutic target;tool;Ultrasonography;ultrasound;Velocimetries;Ventricular;Vesico-Ureteral Reflux;Visualization;Work

PROJECT_TITLE: Eye as a Window into Brain Health in Pediatric Hydrocephalus

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Burden of Illness;Cancer;Clinical Research;Complementary and Integrative Health;Social Determinants of Health

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: The Emotional Well-Being and Economic Burden (EMOT-ECON) Research Network will bring together leading scientists across disciplines and institutions to understand how, and through which mechanisms, the economic burden of disease (e.g., due to costs of care and productivity losses) impacts emotional well-being. By supporting innovative research projects, expanding the pipeline of dedicated researchers, and broadly disseminating findings and resources, the Network will generate a new body of knowledge necessary to develop science-based interventions for reducing the impact of this burden on patients and families, and consequently for enhancing their well-being and overall health.

PI_NAMEs: MARTIN, MICHELLE Y;PISU, MARIA  (contact)

PROGRAM_OFFICER_NAME: QUINLAN, ERIN BURKE

PROJECT_TERMS: Absenteeism at work;Acceleration;Address;Adult;Affect;Area;Attention;Bankruptcy;Behavioral;burden of illness;Cancer Patient;care costs;career;Caregivers;Caring;Charge;chemotherapy;Clinical;Communication;coping;COVID-19 patient;Data Analyses;Dedications;design;Development;Discipline;Disease;Distress;Economic Burden;economic impact;Elements;Emotional;Environment;experience;experimental study;Family;Financial Hardship;Funding;Funding Mechanisms;Goals;Health;Health Personnel;Healthcare;innovation;Institution;Intervention;Intubation;Investments;Knowledge;Leadership;Letters;Life;life span;Life Style;Light;Literature;Malignant Female Reproductive System Neoplasm;Measurement;Medical;meetings;member;multidisciplinary;New York;news;novel;Nurses;Observational Study;Ontology;Outcome;Patients;Personal Satisfaction;Persons;Physicians;Pilot Projects;Policy Maker;Population Heterogeneity;prevent;Prevention Research;productivity loss;programs;psychologic;Psychologist;recruit;Reporting;Research;Research Personnel;Research Priority;Research Project Grants;Resource Sharing;Resources;response;Role;Savings;Science;scientific organization;Scientist;social media;Source;Spouses;Stress;success;symposium;Testing;theories;therapy development;Time;Treatment Cost;Ventilator;virtual;web site;webinar;Well in self;Work

PROJECT_TITLE: Emotional Well-Being and Economic Burden Research Network


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Osteoporosis;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative Blood vessels provide active support for bone formation beyond just acting as channels for blood, though which types of blood vessels provide this support and how these blood vessels alter the production of bone forming cells from their stem cell progenitors is unknown. We have recently discovered a growth factor for skeletal blood vessels, SLIT3, and will here use SLIT3 as a tool to address these questions and establish key paradigms for interactions between blood vessels and bone forming cells.

PI_NAMEs: GREENBLATT, MATTHEW BLAKE (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Address;Adopted;Anatomy;angiogenesis;Angiogenic Factor;Area;arteriole;Automobile Driving;Blood;Blood Vessels;bone;bone fracture repair;bone growth factor;bone loss;Categories;Cell Communication;Cell Lineage;cell type;Cells;cellular targeting;Clinical;Coculture Techniques;Complement;Coupling;Discontinuous Capillary;drug development;Drug Targeting;Endothelial Cells;Endothelium;Foundations;Growth Factor;LEPR gene;Location;Mediating;Mesenchymal;Mesenchymal Stem Cells;Mesenchyme;Metabolic Bone Diseases;Modeling;Morphology;mouse model;new growth;novel;novel strategies;Osteoblasts;Osteoclasts;Osteogenesis;Osteoporosis;Pathway interactions;Phenotype;Physiological;Play;Population;Postmenopausal Osteoporosis;prevent;Production;progenitor;receptor;Regulation;Reporting;response;Role;Shapes;Signal Induction;Signal Transduction;skeletal;skeletal disorder;skeletal stem cell;Source;stem cell population;stem cells;Stimulus;Structure;Supporting Cell;Testing;Therapeutic;therapeutic candidate;tool;Transplantation;Vascular Endothelial Cell;Vascular Endothelium;Work

PROJECT_TITLE: "Establishing Pathways for Endothelial Support of Bone Formation with SLIT3"

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Narrative Concerns of permanent undesirable off-target DNA edits has hampered acceptance of genomic editing tools to treat genetic disorders. The long-term goal of this proposal aims to treat these disorders by selectively editing the RNA transcripts to produce functional protein. Guide oligonucleotides will be screened and optimized to target mRNA mutations that can be repaired by the cell’s RNA editing enzymes.

PI_NAMEs: FISHER, ANDREW J (contact)

PROJECT_TERMS: ADAR1;Adenosine;Amino Acids;analog;base;base editing;Base Pairing;Binding;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Codon Nucleotides;Complex;Cryoelectron Microscopy;Cystic Fibrosis;Data;Deaminase;Deamination;design;Disease;DNA;Double-Stranded RNA;DRADA2b protein;dsRNA adenosine deaminase;Enzymes;experience;experimental study;Future;Genetic Diseases;Genome;genome editing;Goals;Guanosine;Guide RNA;Half-Life;high throughput screening;Human;improved;innovation;Inosine;insight;Knowledge;Lead;lead optimization;Length;Location;Messenger RNA;Metabolic;Methods;Minor;Molds;Muscular Dystrophies;Mutate;Mutation;Nonsense Mutation;novel;nucleobase;nucleotide analog;Nucleotides;Oligonucleotides;Parkinson Disease;Pathogenicity;Point Mutation;Positioning Attribute;Proteins;rational design;Reaction;Regulation;repaired;Reporting;Resolution;RNA;RNA Editing;RNA Sequences;Sequence Analysis;side effect;Single Nucleotide Polymorphism;Site;Structure;Syndrome;Techniques;Terminator Codon;tool;Transcript;Translations;Variant;X-Ray Crystallography

PROJECT_TITLE: High-throughput screening and structure-guided optimization of oligonucleotides for site-directed RNA editing by ADARs.

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Gene Therapy;Genetics;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: DURHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECTIVE NARRATIVE Data generated from the proposed studies will lay the foundation for translating an innovative gene therapy approach to patients with GSD III. The technologies to be utilized in this proposal can be broadly used for gene therapy development for other inherited disorders.

PI_NAMEs: SUN, BAODONG  (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: adaptive immune response;adeno-associated viral vector;Adult;Affect;Age;Age Months;analog;autosome;Bacillus subtilis;beta Actin;Biochemical;Biological Markers;Blood;canine model;Canis familiaris;Capsid;Cardiac;Carrying Capacities;cell type;Cells;Chickens;clinical candidate;clinical translation;Clinical Trials;Complementary DNA;curative treatments;Cytomegalovirus;Cytotoxic T-Lymphocytes;Data;de-immunization;Defect;Dependovirus;Development;Dextrins;dietary;Disease;DNA cassette;Dose;effective therapy;efficacy evaluation;Enhancers;Enzymes;experience;Female;Foundations;Gender;gene therapy;Genes;genome editing;Glycogen;Glycogen Debranching Enzyme;Glycogen Storage Disease Type III;Goals;Hepatocyte;Hepatotoxicity;Hereditary Disease;Histologic;Human;human disease;humanized mouse;Immune response;improved;Infant;Inherited;Innate Immune Response;innovation;Knock-out;Laboratories;Lead;Liver;Liver Cirrhosis;Liver diseases;Liver Failure;liver function;Measurement;Mediating;Metabolic Diseases;Morbidity - disease rate;mortality;mouse model;Mus;Muscle;Muscle Cells;Muscle Fibers;Muscle function;Mutation;Myocardium;Myopathy;novel;old mice;Open Reading Frames;Organ;Outcome;Patients;prevent;promoter;Recording of previous events;Research;response;Safety;Serotyping;Serum;sex;skeletal;Skeletal Muscle;Technology;Testing;therapeutic candidate;therapeutic development;therapy development;therapy outcome;Tissues;Toxic effect;transduction efficiency;transgene expression;Translating;Translations;urinary;Urine;vector

PROJECT_TITLE: Gene therapy for glycogen storage disease type III

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: BROAD INSTITUTE, INC.

PHR: Project Narrative This project proposes to establish a “visible” machine learning framework that systematically understands and efficiently maps higher-order genetic interactions (i.e. di-genic and tri-genic interactions) in cancer. Investigation of higher-order genetic interactions is critical for designing treatments that precisely target the genetic changes in individual cancer patients. Understanding the complex interplay among genes can further lead to effective design of combinatorial therapeutic solutions that maximize the synergy among treatments.

PI_NAMEs: QIN, YUE  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Address;Affinity Chromatography;Architecture;Award;Awareness;Binding Proteins;Biological;Cancer Biology;cancer cell;Cancer cell line;cancer genome;Cancer Patient;Cells;Cellular Structures;combinatorial;Complex;CRISPR screen;Critical Pathways;Data;data integration;data modalities;deep neural network;Defect;design;Educational process of instructing;empowerment;Ensure;experimental study;fitness;Future;gene interaction;Generations;Genes;Genetic;Genetic Engineering;Genetic Predisposition to Disease;Genome engineering;Genomics;Genotype;Image;Immunofluorescence Immunologic;improved;Individual;insight;Interdisciplinary Study;Investigation;Knock-out;knockout gene;large scale data;Lead;Learning;loss of function mutation;Machine Learning;machine learning framework;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Mentors;metabolome;Methods;Mutation;nanometer;Nature;neural network;neural network architecture;Oral;Pathway interactions;Phase;Phenotype;Postdoctoral Fellow;preservation;Proteins;Proteome;Research;Research Personnel;Research Project Grants;Resolution;Resources;skill acquisition;skills;synergism;synthetic lethal interaction;System;targeted treatment;Therapeutic;therapeutically effective;therapy design;Training;transcriptome;tumor;Writing

PROJECT_TITLE: A visible machine learning system to discover targeted treatment solutions in cancer


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: Pasadena

ORG_NAME: HUNTINGTON MEDICAL RESEARCH INSTITUTES

PHR: NARRATIVE Detection of pre-symptomatic Alzheimer’s disease (AD) is difficult to distinguish from typical aging; testing is expensive and invasive. We recently found that functional electroencephalography (fEEG) may detect individuals with pathological amyloid/tau level and higher risk of cognitive decline through conscious, subliminal, and autonomic (CSA) system evaluation. This project will also put to the test how well these new findings will predict who will or will not decline in a period of 2 years.

PI_NAMEs: ARAKAKI, XIANGHONG  (contact);KLONER, ROBERT A

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Address;Affect;Aging;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Autonomic Dysfunction;Benchmarking;Biochemical;Biological Markers;Blood Pressure;Cerebrospinal Fluid;Classification;Clinical;Cognition;Cognitive;cognitive system;cohort;Color;Conscious;Coronary;Data;data reduction;Dementia;density;Detection;Diagnosis;Disease Progression;distraction;Early Diagnosis;effective therapy;Elderly;Electrocardiogram;Electroencephalography;Electrophysiology (science);Entropy;Evaluation;Event;Executive Dysfunction;executive function;Functional disorder;Goals;Health;heart rate variability;high risk;Hyperactivity;Image;Impaired cognition;Impairment;improved;Individual;Information Systems;Knowledge;life span;Longitudinal Studies;Measurement;Measures;Methods;mild cognitive impairment;Modeling;Nervous System;Nervous System Disorder;neural;neurophysiology;Non-Invasive Detection;normal aging;novel;Participant;Pathologic;predictive marker;Reaction Time;Regulation;Reporting;Research;Resources;response;Role;Sensory;Short-Term Memory;Source;source localization;Staging;Stimulus;Stress Tests;subliminal influence;Symptoms;Synapses;synaptic function;System;Systems Biology;tau Proteins;Techniques;Testing

PROJECT_TITLE: Cognitive challenge to reveal systemic neurophysiology biomarkers in pre-symptomatic Alzheimer’s disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Mental Health;Methamphetamine;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Determining whether a patient is both feeling better and improving physiologically when treating people living with HIV (PLWH) for methamphetamine use disorder (MUD) requires identification of a clinically significant measure separate from abstinence. My proposed K01 activities open the exciting opportunity to address this challenge by testing a gene expression pattern identified by the field of social genomics, which may provide insight into both psychosocial health and biological processes that impact chronic disease risk in PLWH receiving MUD treatment. Support from this K01 will facilitate my training in transcriptomics, clinical trial methods, and ethical/culturally competent practices, all of which will help me achieve my long-term career goal—to be a leading researcher of biomarker assessment tools for PLWH receiving addiction treatment.

PI_NAMEs: LI, MICHAEL JONATHAN (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: Abstinence;addiction;Addictive Behavior;Address;Adherence;Alcohols;analytical method;Anti-viral Response;Antibodies;antiretroviral therapy;Anxiety;Area;arm;Assessment tool;Basic Science;Behavior;Behavioral;Behavioral Sciences;biobehavior;Biological;Biological Assay;Biological Markers;Biological Process;Cardiovascular Diseases;career;Caring;Chronic;Chronic Disease;Clinical;Clinical Trials;Clinical Trials Design;clinically significant;comorbidity;Compulsive Behavior;Conflict (Psychology);contingency management;cultural competence;Data Analyses;Development;Dimensions;Discrimination;Disease Progression;disorder risk;Distress;Drug Addiction;drug testing;emotional distress;Employment;Ethics;experience;Faculty;Family;Feeling;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Goals;Health;high risk;HIV;HIV Seropositivity;immune function;improved;indexing;Individual;Inflammation;Inflammatory;Influentials;insight;Interferon Type I;Intervention;Investigation;Learning;Legal;Link;long term recovery;Measurement;Measures;Mediating;Medical;Medicine;men who have sex with men;Mental Depression;Mentored Research Scientist Development Award;Mentors;Mentorship;Methamphetamine;methamphetamine use;Methamphetamine use disorder;Methods;neural;operation;Outcome;Pathogenesis;Patient Self-Report;Patients;Pattern;Personal Satisfaction;Persons;Pharmaceutical Preparations;Physiological;Play;Population;Prevention;primary outcome;procedure safety;Productivity;psychologic;psychosocial;Qualifying;Recovery;Regulatory Pathway;Research;Research Personnel;Research Project Grants;Research Training;response;Role;satisfaction;Severities;social;social genomics;Statistical Methods;Stress;substance use;substance use treatment;success;Testing;therapy adherence;Training;Training Activity;transcriptomics;transmission process;Treatment Efficacy;Treatment outcome;Urine;Violence;Viral;Viral Load result

PROJECT_TITLE: Trajectories of socially regulated gene expression, methamphetamine use, and viral load among HIV-positive men who have sex with men (MSM) receiving contingency management

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Poor muscle function is a pressing public health problem as half of all U.S. older adults meet criteria for muscle weakness. The goal of this proposal is to identify which features of the neighborhood environment are related to muscle function, physical activity and mitochondrial health in older adults. This study’s findings will enhance our understanding of what social and biologic risk factors matter most for muscle function and could be targets for future interventions.

PI_NAMEs: DUCHOWNY, CATHERINE  (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Affect;Aging;aging related;Award;Behavioral;Bioenergetics;Biogenesis;Biological;biological research;built environment;California;career;Cessation of life;Characteristics;Clinical;clinical epidemiology;Cohort Studies;Complex;Data;Data Set;Dedications;design;disability;Disease;Environment;Epidemiologic Methods;experience;Future;Goals;Health;Health and Retirement Study;health data;Individual;insight;Intervention;Link;Measurement;Measures;Mediating;Mediation;Mentorship;Mitochondria;multidisciplinary;multiple chronic conditions;Muscle;Muscle function;Muscle Mitochondria;muscle physiology;muscle strength;Muscle Weakness;Musculoskeletal;Neighborhoods;older adult;Outcome;Pathway interactions;Phase;Physical activity;Physiology;Positioning Attribute;prevent;Public Health;reduced muscle strength;Research;Risk Factors;Role;San Francisco;Skeletal Muscle;skills;Skin;social;social culture;Social Environment;social epidemiology;social health determinants;Social Sciences;Testing;Training;Universities;walkability;Work

PROJECT_TITLE: Examining the role of the neighborhood environment on muscle function in older adults

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Narrative The proposed research is relevant to public health because it will define how cooperation between oncogenic signaling and the microenvironment affects therapy of poor prognosis T-ALL. This work will build a foundation for validating new molecular targets in relapsed and refractory T-ALL and provide a proof-of-principle for an alternative strategy in which entire molecular circuits are considered during the development of therapies.

PI_NAMEs: CARLESSO, NADIA  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Acute Lymphocytic Leukemia;Acute T Cell Leukemia;Affect;Anthracycline;Apoptosis;asparaginase;BCL2 gene;Biological Assay;Biology;c-myc Genes;cancer type;Cell Cycle;Cell Line;Cell model;Cell Proliferation;Cell Survival;Cells;Cessation of life;chemotherapy;Childhood;Clinical;Compensation;CRISPR/Cas technology;Cyclophosphamide;Data;Development;Dexamethasone;disease model;effective therapy;effectiveness evaluation;EMSA;Event;Exhibits;Feedback;Foundations;gain of function mutation;Gene Silencing;Genetic;Genetic Transcription;Growth Factor;Human;IL7 gene;IL7R gene;Impairment;improved;inhibitor;insight;Interleukin 7 Receptor;Interruption;knowledgebase;Lead;leukemia;leukemia initiating cell;leukemia relapse;leukemia/lymphoma;Leukemic Cell;leukemogenesis;Ligands;Link;Maintenance;Malignant - descriptor;Malignant Childhood Neoplasm;Maps;Measures;Mediating;Mediator;Methotrexate;Modeling;Molecular;Molecular Analysis;Molecular Target;molecular targeted therapies;Mus;Mutation;new therapeutic target;notch protein;Notch Signaling Pathway;novel therapeutic intervention;Oncogenes;Oncogenic;Outcome;overexpression;Pathway interactions;patient derived xenograft model;Patients;pharmacologic;Phosphorylation;Play;pre-clinical;Pre-Clinical Model;Prognosis;Proliferating;promoter;Public Health;Recurrent disease;Refractory;Refractory Disease;Regulation;Relapse;Research;Role;Sampling;Signal Transduction;SKP2 gene;STAT3 gene;Stat5 protein;success;Surface;Survival Rate;T-Cell Leukemia;T-Lymphocyte;Testing;Therapeutic;Therapeutic Intervention;therapy development;transcription factor;Transcriptional Activation;Transcriptional Regulation;translational impact;tumor;tumorigenesis;Work

PROJECT_TITLE: Targeting the Microenvironment/Oncogene Cooperation to treat poor prognosis T-ALL

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Complementary and Integrative Health;Women's Health Research

ORG_CITY: Chicago

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Narrative (Relevance) Hypoxia is one of the most important features of the tumor microenvironment (TME) that leads to decreased sensitivity of tumor cells and poor therapeutic effects. We developed unique tools using engineered probiotic tumor-homing bacteria to selectively express cancer-killing proteins under the hypoxic environment. In combination with chemotherapeutic agents, our new probiotic bacteria-assisted approach will potentially provide effective treatment strategies that specifically target the hypoxic TME which is difficult by current therapeutic options.

PI_NAMEs: YAMADA, TOHRU  (contact)

PROGRAM_OFFICER_NAME: RASOOLY, AVRAHAM

PROJECT_TERMS: Acidity;Address;advanced breast cancer;Anaerobic Bacteria;Animal Model;Antineoplastic Agents;Area;Bacteria;Bacterial Proteins;Biodistribution;Biometry;Blinded;Blood flow;Breast Cancer Treatment;Cancer Biology;cancer cell;cancer imaging;cancer therapy;cancer type;Cells;Characteristics;chemotherapeutic agent;chemotherapy;Clinical;cupredoxin;Data;design;Development;Doxorubicin;effective therapy;Effectiveness;Engineered Probiotics;Engineering;Environment;Escherichia coli;Exhibits;Experimental Designs;Face;Flagella;Gene Modified;Genes;Homing;Human;Hypoxia;immunogenicity;Immunology;improved;in vivo;inducible gene expression;Induction of Apoptosis;Infusion procedures;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Medical;microbial;Microbiology;migration;Molecular Biology;multidisciplinary;Mus;Neoplasm Metastasis;neoplastic cell;normoxia;novel strategies;opportunistic pathogen;Outcome;Oxygen;Paclitaxel;Pathology;patient derived xenograft model;Perfusion;Pharmaceutical Preparations;pre-clinical;pre-clinical research;Probiotics;Procedures;Prognosis;promoter;Proteins;Pseudomonas aeruginosa;Published Comment;Recombinants;Resistance;Risk;Role;Safety;selective expression;Solid Neoplasm;spheroids;System;targeted treatment;Testing;Therapeutic;Therapeutic Effect;therapeutic target;tool;Toxic effect;Transgenic Mice;treatment strategy;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor hypoxia;tumor microenvironment;tumor progression;United States National Institutes of Health;Xenograft procedure

PROJECT_TITLE: Hypoxia-activated probiotic agents for breast cancer


NIH_SPENDING_CATS: Clinical Research;Hematology;Infectious Diseases;Orphan Drug;Rare Diseases;Sickle Cell Disease

PHR: PROJECT NARRATIVE Neutrophils, a class of white blood cells that combat bacteria, can become overactive when fighting overwhelming infection in a condition called sepsis, releasing anti-bacteria compounds that contribute to life- threatening organ damage. I propose a new therapy that neutralizes these dangerous compounds without interfering with neutrophils’ ability to control infections. My goal is to further understand how this strategy works and to bring it to patient care to improve survival in sepsis and other conditions complicated by neutrophil-related inflammation, such as sickle cell disease.

PI_NAMEs: GOLLOMP, KANDACE  (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Acute;acute care;antimicrobial;Bacteria;Bacterial Infections;Basic Science;bench to bedside;Binding;Blood Platelets;Blood specimen;Blood Vessels;Body System;career;career development;Cations;cell free DNA;cell injury;Cell Line;Charge;chemokine;Child Care;Childhood;Chronic;clinical care;Collaborations;combat;Comparative Study;Complex;cytokine;Dangerousness;Deoxyribonucleases;Development Plans;Digestion;Disease;DNA;Electrostatics;Encapsulated;Endothelial Cells;Endothelium;Escherichia coli;extracellular;fighting;Functional disorder;Goals;Gram-Positive Bacteria;Growth;Hemolysis;Hemolytic Anemia;Heparin;Histones;Human;immunothrombosis;improved;improved outcome;In Vitro;in vivo;Infection;Infection Control;Inflammation;Inflammatory;Infusion procedures;Injury;Innate Immune Response;insight;Internet;Intervention;Left;Leukocytes;Life;Measures;Mediating;Mentorship;Microbe;microbial;Microfluidics;Modeling;Modification;Monoclonal Antibodies;mouse model;multidisciplinary;Mus;mutant;neutrophil;novel;novel strategies;novel therapeutics;nuclease;Organ;Organism;Pain;pathogen;Patient Care;Patients;Peroxidases;PF4 Gene;Plasma;Play;polyanion;preservation;prevent;Production;Proteins;Research Personnel;Resistance;response;Risk;Risk Reduction;Role;Sampling;Scientist;Sepsis;Severity of illness;Sickle Cell Anemia;Sickle Hemoglobin;Staphylococcus aureus;Stimulus;Streptococcus pneumoniae;Surface;targeted treatment;Testing;Therapeutic;Therapeutic Studies;Thrombocytopenia;thromboinflammation;Thrombosis;Tissues;Toxic Neutrophil;TRAP Complex;Variant;vascular inflammation;Vasculitis;Work

PROJECT_TITLE: NET stabilization: mechanistic and therapeutic studies in thromboinflammatory disoders


ORG_CITY: HOUSTON

ORG_NAME: MICHAEL E DEBAKEY VA MEDICAL CENTER

ORG_STATE: TX

PHR: Patients with metastatic lung cancer receive standard chemo, radiation, and immune therapy. However, treatment resistance occurs in over 70% of the cases. Solid tumors suppress the immune system preventing effective systemic responses. We have found that tumors from unrelated donors fail to establish in new hosts because the immune system attacks unrelated tissue. Similarly, matched tissue type cancer injected with pooled antibodies plus an activator of the immune system can cause the eradication of tumors. We plan to use this immune activation strategy in a safety trial. Unrelated antibodies and an immune activator will be injected in a first-in- human single-center study Harnessing Allo-Immunity To Enhance Immune Checkpoint Inhibitors (HAITEN-ICI) in veterans with metastatic lung cancer who failed standard cancer treatment. We will evaluate the safety of this intervention and if safe, will be expanded to a randomized study.

PI_NAMEs: KHERADMAND, FARRAH  (contact);SABICHI, ANITA L

PROJECT_TERMS: adaptive immune response;Adjuvant;Adjuvant Therapy;Aftercare;Agonist;Antibodies;Antigen-Antibody Complex;Antigen-Presenting Cells;Antigens;Antitumor Response;arm;Binding;Biological;Cancer Patient;cancer therapy;cancer type;candidate identification;chemotherapy;Clinical;Clinical Data;Clinical Trials;cohort;Combined Modality Therapy;Data;Deposition;Disease;Distant Metastasis;Dose;Dose Limiting;Eligibility Determination;Enrollment;Evaluation;first-in-human;Geography;Human;immune activation;immune activator;Immune checkpoint inhibitor;Immune response;Immune system;Immunoglobulins;Immunologic Adjuvants;Immunotherapy;Implant;improved;Injections;Intervention;Intramuscular;Intramuscular Injections;Isoantibodies;isoimmunity;Lung;lung cancer screening;Malignant neoplasm of lung;Maximum Tolerated Dose;Mus;Non-Small-Cell Lung Carcinoma;novel;novel strategies;oncology program;Outcome;partial response;participant enrollment;patient population;Patients;Peripheral;Phase;phase 1 study;phase 2 study;phase I trial;Pilot Projects;Poly ICLC;Pre-Clinical Model;precision oncology;prevent;primary endpoint;Progression-Free Survivals;Radiation therapy;Randomized;randomized, clinical trials;Refractory;response;Safety;Site;Smoker;Solid Neoplasm;Stable Disease;standard of care;Technology;Testing;therapy resistant;Tissues;Toxic effect;translational study;treatment arm;treatment strategy;tumor;tumor eradication;Tumor Immunity;Veterans

PROJECT_TITLE: Harnessing Allo-immunity to Enhance Immune Checkpoint Inhibitor Responses in Advanced NSCLC

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 SPLP-Y (01)]


ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative The relationship between adipose tissue and its resident lymphatic vasculature is complex and bidirectional. While defective lymphatic function, as seen in lymphedema, promotes fat deposition, obesity, conversely, compromises lymphatic flow. By exploring lymphatic endothelial cell communication with other adipose tissue cell types, this proposal aims to improve our understanding of how the lymphatic system contributes to adipocyte biology and overall metabolic health.

PI_NAMEs: WESTCOTT, GREGORY  (contact)

PROGRAM_OFFICER_NAME: HAFT, CAROL R

PROJECT_TERMS: Acceleration;adipocyte biology;Adipocytes;Adipose tissue;Adult;Affect;Animal Model;Area;Biological;Biology;Body Composition;Body fat;Body Weight;Boston;Breast Cancer Treatment;career;career development;Cell Communication;cell type;Cells;Chronic;Clinical;Collaborations;Complex;Data;Deposition;Desire for food;Development;Disease;energy balance;Evaluation;Excision;experience;Extracellular Fluid;Fatty acid glycerol esters;Functional disorder;Future;Gene Expression;Gene Expression Profile;Genetic Transcription;Goals;Health;Histologic;Histology;Homeostasis;Hormones;Human;human subject;Hypertrophy;Immune;Impairment;improved;insight;Insulin Resistance;Intercellular Fluid;interest;Knockout Mice;Leptin;leptin receptor;Leptin resistance;Ligands;Lipedema;Liquid substance;lymph flow;lymph nodes;Lymphangiogenesis;Lymphatic;Lymphatic clearance;Lymphatic Diseases;lymphatic dysfunction;Lymphatic Endothelial Cells;Lymphatic function;lymphatic malformations;Lymphatic System;lymphatic vasculature;lymphatic vessel;Lymphedema;Mediating;Mentors;Mentorship;Metabolic;Metabolic dysfunction;Metabolism;mouse model;Mus;Neurotensin;Obesity;Operative Surgical Procedures;Paracrine Communication;Pathology;Patients;Permeability;Physicians;Physiology;Prevalence;Program Development;programs;Proliferating;Publishing;receptor;Regulation;Resolution;Resources;Risk Factors;Role;Scientist;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;skills;subcutaneous;System;Techniques;Thermogenesis;Tissue Differentiation;Tissue Expansion;Tissues;trafficking;Tube;uptake;Vascular System;Weight Gain;Work

PROJECT_TITLE: Lymphatic-adipocyte interactions in obesity and lymphedema


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences

ORG_CITY: CHARLESTON

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: Project Narrative Despite age-related hearing and vision deficits, some older adults can identify audiovisual speech as accurately as their younger counterparts. This research project takes a novel neural-systems approach, integrating measures of neural function with structure, to characterize the age-related changes in cross-modal plasticity, multisensory integration, and frontal-cortical modulation of sensory input that may conserve the audiovisual speech perception of older adults. The findings may identify new targets for intervention to improve the communicative abilities of older adults with hearing and vision loss.

PI_NAMEs: DIAS, JAMES WILLIAM (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Affect;Age;age difference;age effect;age group;age related;age related changes;Area;audiovisual speech;Auditory;Auditory area;Auditory Evoked Potentials;auditory stimulus;behavior test;Blindness;Cognitive;cognitive ability;Communication;Compensation;Development;Diffusion;Electrophysiology (science);Evoked Potentials;Exhibits;frontal lobe;Hearing;hearing impairment;Image;improved;Individual Differences;individual variation;Inferior;innovation;interest;Intervention;Knowledge;Measures;Modality;Modeling;multisensory;neural;neuromechanism;Neurophysiology - biologic function;novel;older adult;Patient Self-Report;preservation;processing speed;programs;Research;Research Project Grants;response;Role;Sensory;sensory cortex;sensory input;sensory integration;sensory stimulus;Source;Speech;speech in noise;Speech Perception;Stream;structural imaging;Structure;System;Testing;Translating;transmission process;Vision;Visual;Visual Cortex;Visual evoked cortical potential;visual speech;visual stimulus;white matter;young adult

PROJECT_TITLE: Neural Determinants of Age-Related Changes in Cross-Sensory Plasticity and Multisensory Integration Affecting Audiovisual Speech Perception


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Nutrition;Sleep Research

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Sleep and circadian rhythms, our 24-hour internal biological clock, are essential to human well-being and patient recovery, however current modifiable practices in intensive care units (ICU) are not optimized to support sleep or preserve circadian rhythms of patients. Among the contributing factors is the common practice of administering nutrition support through feeding tubes or intravenously overnight. Thus, using noninvasive and scalable monitoring technologies, we propose to determine whether modifying the timing of nutrition support from the current standard of overnight feeding to daytime feeding may enhance sleep quality, preserve circadian rhythms, and improve overall inflammation and cardiometabolic profiles in postoperative patients in the cardiac surgical ICU on enteral nutrition.

PI_NAMEs: DASHTI, HASSAN S. (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: actigraphy;Acute;Adult;Affect;American;Area;Arousal;Attenuated;bench-to-bedside translation;Biological;Biological Assay;Biological Clocks;Biological Markers;Blood Glucose;Blood Pressure;C-reactive protein;Cardiac;cardiac intensive care unit;Cardiac Surgery procedures;cardiometabolism;Chronobiology;circadian;circadian pacemaker;Circadian Rhythms;Clinical;clinical care;Clinical Nutrition;Clinical Research;clinical translation;clinical trial implementation;Clinical Trials;Computerized Medical Record;Critical Care;Critical Illness;Cross-Over Trials;Data;Delirium;Dietitian;Dimensions;Disease;Eating;Enteral Feeding;Enteral Nutrition;Environment;Evaluation;feeding;Feeds;Food;Gene Expression Profile;Genomic medicine;Glucose;Goals;Grant;Health;Home Parenteral Nutrition;Hospitalization;Hour;Human;human subject;impaired glucose tolerance;Impairment;improved;Inflammation;Inflammatory;Intensive Care Units;Interdisciplinary Study;Interleukin-6;Intravenous;Light;Measures;Mediating;Mediation;Medical;metabolomics;Middle Insomnia;Monitor;monocyte;Morbidity - disease rate;Noise;Nonpharmacologic Therapy;novel;nutrition;Nutritional Study;OGTT;Oral;Outcome;Parenteral Nutrition;Participant;Pathway interactions;Patient Care;patient population;Patients;Personal Satisfaction;Phase;Phenotype;Physiological;Plasma;Polysomnography;Positioning Attribute;Postoperative Period;precision nutrition;preservation;prevent;programs;Randomized;Recovery;Research;Research Personnel;response;Risk;Serum;Sleep;Sleep disturbances;Sleep Fragmentations;sleep quality;Societies;Strategic Planning;Technology;Temperature;Testing;Time;TNF gene;Training;Transcript;transcriptomics;United States National Institutes of Health

PROJECT_TITLE: The impact of overnight nutrition support on sleep and circadian rhythm disruption in the ICU

STUDY_SECTION: NSS


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Networking and Information Technology R&D (NITRD)

ORG_CITY: RIVERSIDE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: Narrative  Errors in the genome can often give rise to plethora of genetic diseases, including cancer and neurodegeneration and, in recent years, the CRISPR-Cas9 complex has emerged as promising genome editing machinery to treat a myriad of human genetic diseases as shown for the first cancer patients treated with CRISPR-Cas9–modified T-cells. This prosed research will leverage state-of-the-art computational methods to answer critical biophysical questions and foster improved applications of the CRISPR-Cas9 genome editing technology. Understanding the fundamental functional behaviour of this complex is of utmost importance to ameliorate safety and efficacy for clinical applications.

PI_NAMEs: PALERMO, GIULIA  (contact)

PROJECT_TERMS: Acceleration;Address;Affect;Allosteric Regulation;Applied Research;Basic Science;Behavior;Binding;Biological Sciences;Biology;biophysical analysis;biophysical properties;Biophysics;Cancer Patient;Catalysis;Catalytic Domain;Cells;clinical application;clinical efficacy;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complementary DNA;Complex;computer framework;Computer Simulation;computer studies;Computing Methodologies;CRISPR/Cas technology;dalton;Data;Dependence;Development;divalent metal;DNA;DNA Binding;DNA Sequence;DNA Sequence Alteration;endonuclease;Engineering;Enzymes;Event;Exhibits;Fostering;Free Energy;functional improvement;Gene Expression Regulation;Genetic Diseases;Genome;genome editing;Grant;graph theory;Guide RNA;Human Genetics;improved;inhibitor;innovation;Investigation;Ionic Strengths;Ions;Kinetics;Knowledge;Malignant Neoplasms;Measurement;Mediating;Metabolism;Metals;Methods;Molecular Conformation;molecular dynamics;molecular mechanics;nanosecond;Nerve Degeneration;network models;novel;nuclease;Nucleic Acid Binding;Nucleic Acids;Organism;Outcome;prevent;Proteins;Protocols documentation;Quantum Mechanics;Research;Ribonucleoproteins;Role;Safety;Sampling;Scientist;Series;Signal Transduction;Site;Specificity;System;T-Lymphocyte;Technology;Theoretical Studies;tool;transmission process;uptake;Variant;viral detection

PROJECT_TITLE: Investigating the metal-dependent function, allostery and inhibition of CRISPR-Cas9

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


PHR: PROJECT NARRATIVE Cardiovascular disease is the number one cause of mortality in the United States, with different etiologies of heart failure associated with distinct changes in mitochondrial substrate selection, utilization, and gene expression mediating these differences. Here we test the hypothesis that one family of kinases that regulate this process (i.e., PDKs) play distinct roles in mortality, cardiac hypertrophy, mitochondrial oxidative metabolism, and signaling to transcriptional pathways in the nucleus mediated by epigenetics (i.e., histone acetylation). We have developed new animal model systems of inducible and cardiomyocyte specific loss-of-function mice of the two cardiac enriched isoforms of this pathway (i.e., PDK2 and PDK4) to determine the mechanism of this regulation and test the potential of their isoform-specific impact on pressure-overload induced heart failure.

PI_NAMEs: WENDE, ADAM RAYMOND (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Acetyl Coenzyme A;Acetylation;Adipose tissue;Adult;anaerobic glycolysis;Animal Model;aorta constriction;Attenuated;attenuation;Biological Models;Cardiac;Cardiac Myocytes;cardioprotection;Cardiovascular Diseases;Cause of Death;Cell Nucleus;Cell Respiration;Cessation of life;Citric Acid Cycle;Confocal Microscopy;Data;Development;Diagnosis;Dichloroacetic Acid;EFRAC;Epigenetic Process;epigenetic regulation;Etiology;Exercise;Exhibits;Family;Fibrosis;Functional disorder;Gene Expression;Gene Expression Regulation;Generations;Genetic;Genetic Transcription;Germ Lines;Glucose;Glycolysis;Goals;Heart;Heart Diseases;Heart failure;Heart Hypertrophy;hemodynamics;Histologic;Histone Acetylation;Histone Code;Histones;Homeostasis;Hypertrophy;In Vitro;Individual;insight;kinase inhibitor;Knock-out;Knockout Mice;Knowledge;Laboratories;Link;Liver;loss of function;Mediating;Metabolic;Metabolic Control;Mitochondria;Modeling;Molecular;Morphology;mortality;mouse model;Mus;Myocardial dysfunction;Nodal;novel;Nuclear;Operative Surgical Procedures;oxidation;Pathogenesis;Pathologic;Pathway interactions;PDH kinase;PDPK1 gene;phosphoproteomics;Phosphorylation;Phosphorylation Inhibition;Phosphotransferases;Physiological;Play;Post-Translational Protein Processing;preservation;pressure;prevent;Process;Protein Acetylation;Protein Isoforms;Pyruvate;pyruvate dehydrogenase;Pyruvate Dehydrogenase Complex;Regulation;Reporting;Research;response;Role;Signal Transduction;Site;Site-Directed Mutagenesis;Skeletal Muscle;Stimulus;Stress;Survival Rate;Testing;Therapeutic;therapeutic candidate;Therapeutic Intervention;therapeutically effective;Tissues;tool;Transcriptional Regulation;transcriptional reprogramming;United States

PROJECT_TITLE: Novel roles of PDK2 in heart failure: Regulation of mitochondrial nuclear crosstalk via metabolic regulation and histone acetylation


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: Project Narrative Structural racism and discrimination (SRD) places rural Black Americans at the highest risk for virtually every adverse health outcome. We will measure the short- and long-term consequences of adolescent SRD exposure and gather evidence on structural leverage points that will enable future interventions to have the greatest impact.

PI_NAMEs: GOTTFREDSON O'SHEA, NISHA  (contact);TAGGART, TAMARA

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: Acceleration;Adolescence;Adolescent;Adult;Affect;American;Black American;Black Populations;Black race;Buffers;Censuses;Characteristics;Child;cohort;combat;Communities;Community Surveys;County;Data;Data Sources;Development;Dimensions;Discipline;Discrimination;Eligibility Determination;emerging adulthood;experience;Exposure to;Funding;Future;Goals;Health;Health Services Accessibility;high risk;Housing;Imprisonment;Individual;Inequity;innovation;Institution;Intervention;Investments;Legal;Legal system;Life Cycle Stages;Maps;Measures;Mediation;Mental Health;neighborhood disadvantage;Neighborhoods;North Carolina;novel;Outcome;Participant;peer networks;Penetration;Policies;Positioning Attribute;Poverty;Property;psychological distress;Race;racial bias;racial diversity;Racial Segregation;Records;Research Design;resilience;resilience factor;Risk;Rural;rural area;rural counties;Rural Population;rural setting;Schools;service organization;social;Social Network;Source;Structural Racism;Structure;Students;substance use;Surveys;Suspensions;System;Taxes;theories;twelfth grade;Unemployment;United States National Institutes of Health;urban health disparities;virtual

PROJECT_TITLE: Measuring the impact of structural racism and discrimination during adolescence on substance use, psychological distress


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

PHR: Project Narrative: Cocaine use disorder is a leading cause of drug overdose hospitalizations with no available FDA approved medication. By focusing on the novel regulator Fgf13 in the hippocampus, I will investigate how drug contextual memory can be manipulated in a mouse model of cocaine seeking. I aim to reduce the public health burden of cocaine use disorder with the ultimate goal of identifying a pharmacological target for treatment.

PI_NAMEs: LIN, SUSAN  (contact)

PROGRAM_OFFICER_NAME: BABECKI, BETH

PROJECT_TERMS: Action Potentials;Acute;addiction;Adult;Alternative Splicing;Animals;Antibodies;Behavior;behavioral phenotyping;behavioral study;Binding;Brain;Brain region;Cause of Death;cell type;Cells;Cocaine;Cocaine Dependence;cocaine exposure;cocaine related behaviors;cocaine seeking;Cocaine use disorder;conditioned place preference;conditioning;Custom;Defect;density;differential expression;Dorsal;Down-Regulation;Drug Addiction;Electrophysiology (science);Environment;Excitatory Postsynaptic Potentials;experience;experimental study;Extinction;FDA approved;Fellowship;Female;Fibroblast Growth Factor;fibroblast growth factor 13;Genes;Goals;Health;Hippocampus;Hospitalization;Hour;improved;In Situ Hybridization;Individual;Interneurons;Knock-out;Knockout Mice;Label;Link;Long-Term Potentiation;LoxP-flanked allele;Maintenance;male;Measures;Mediating;Medicine;Memory;memory acquisition;Mission;Modeling;Molecular;molecular marker;mouse model;Mus;mutant;National Institute of Drug Abuse;neuronal excitability;Neurons;Neurosciences;Nitric Oxide Synthase Type I;novel;Overdose;overdose death;Parvalbumins;Performance;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Play;preference;programs;Property;Protein Isoforms;Protocols documentation;psychosocial;Public Health;Pyramidal Cells;Regulation;Reporter;Reporting;Research;response;reward circuitry;Rewards;Risk;Role;Signal Transduction;Slice;Sodium Channel;Somatostatin;Stains;Substance abuse problem;Synaptic plasticity;Tamoxifen;Technical Expertise;Techniques;Testing;tool;Training;United States;Viral;voltage;Work

PROJECT_TITLE: FGF13 Control of Hippocampal Excitability in Cocaine Contextual Memory


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: EL PASO

ORG_NAME: UNIVERSITY OF TEXAS EL PASO

PHR: Project Narrative: The overarching goal of the U-RISE at UTEP is to increase the participation and retention of undergraduate students from underrepresented groups in biomedical research through training opportunities that prepare them for advanced degrees in the biomedical sciences and ultimately contribute to the diversity in the biomedical research workforce.

PI_NAMEs: AGUILERA, RENATO J (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Awareness;Biochemistry;Biological Sciences;Biomedical Research;career;Chemistry;cohort;Communities;Counseling;Degree program;Development;Doctor's Degree;Educational workshop;Enrollment;expectation;Extramural Activities;Funding;Goals;improved;interest;Knowledge;Mentors;Mentorship;Mission;Modeling;Oral;Outcome;Paper;programs;Psychology;Publications;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Science;skills;summer research;Talents;Technical Expertise;Texas;Training;training opportunity;Training Programs;undergraduate student;Underrepresented Populations;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: U-RISE at the University of Texas at El Paso

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Genetics;Human Genome;Prevention

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: NARRATIVE Genome instability, including changes in DNA sequence and chromosome structure, is associated with cancer, birth defects, and neurological and developmental disorders. This project uses genetics and cell biology in a simple yeast to study how cells protect their DNA to ensure faithful transmission of the genetic information. This organism uses many of the same genes as humans for this vital task, allowing us to investigate molecular mechanisms and identify proteins that preserve chromosome stability and prevent disease.

PI_NAMEs: FORSBURG, SUSAN L (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: 3-Dimensional;Address;Affect;Aging;Biological;Biology;biomarker identification;Cell model;Cell Physiology;Cells;Cellular biology;Centromere;Characteristics;Chromosomal Stability;Chromosome Fragile Sites;Chromosome Segregation;Chromosome Structures;Chromosomes;Congenital Abnormality;Cytoprotection;Data;Defect;Development;developmental disease;Disease;DNA;DNA biosynthesis;DNA Repair;DNA replication fork;DNA Sequence;Ensure;Eukaryotic Cell;Event;Fission Yeast;gene discovery;Genes;Genetic;genetic information;Genetic Models;Genome Stability;Genomic Instability;Goals;Health;Human;human disease;Infertility;Link;live cell imaging;Malignant Neoplasms;Meiosis;Mitosis;Molecular;mutant;Nervous System Disorder;Neurologic;Normal Cell;novel;Organism;Pathology;Pathway interactions;Phase;preservation;prevent;Proteins;repaired;replication stress;Resolution;response;Ribosomal DNA;Risk Factors;Role;Stress;Structure;Systems Biology;tool;transmission process;Yeasts

PROJECT_TITLE: Mechanisms linking replication stress to genome instability in fission yeast

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]