NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Prevention;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE This study addresses knowledge gaps in personalized colorectal cancer surveillance in Lynch syndrome (LS). A prospective trial will measure FIT performance in LS, and modeling will evaluate integration of non-invasive tests with colonoscopy for LS surveillance. A key deliverable will be the 1st prospective LS biobank in the US.

PI_NAMEs: KASTRINOS, FAY ;KUPFER, SONIA  (contact);STOFFEL, ELENA MARTINEZ

PROGRAM_OFFICER_NAME: CROSWELL, JENNIFER

PROJECT_TERMS: Address;Adherence;Adult;Affect;Age;American;Attitude;biobank;Biological Markers;Blood;blood-based biomarker;Caring;Characteristics;Clinical;clinical care;clinical practice;Clinical Research;cohort;Collaborations;Colon Carcinoma;Colonic Adenoma;Colonoscopy;Colorectal Cancer;colorectal cancer risk;colorectal cancer screening;Colorectal Neoplasms;Complement;cost;cost effective;COVID-19 pandemic;data harmonization;Defect;Development;Emergency response;Enrollment;Evaluation;Feces;Funding;Future;General Population;Genes;Geography;Hereditary Nonpolyposis Colorectal Neoplasms;improved;Incidence;Individual;Inherited;International;Knowledge;lifetime risk;Longevity;Malignant Neoplasms;marginalized population;Measures;Mismatch Repair;Modeling;models and simulation;Multicenter Trials;Outcome;pandemic disease;Patients;Performance;performance tests;Population Heterogeneity;Positioning Attribute;Predictive Value;Procedures;prospective;Prospective cohort;Prospective Studies;Recommendation;recruit;Reporting;Research;Resources;Risk;Screening for cancer;Specificity;surveillance strategy;Surveys;Testing;Translating;Translational Research;Triage;United Kingdom

PROJECT_TITLE: FITting noninvasive testing into Lynch syndrome colorectal cancer surveillance: a multicenter, prospective trial

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: CINCINNATI

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative We discovered that the Rho GTPase Cdc42 controls Treg cell-mediated immune response against tumor cells. This project will develop selective, non-toxic, and effective small molecules targeting Cdc42 for cancer immunotherapy modulation. It will establish a novel proof of principle that pharmacological targeting of Cdc42 in Treg cells can benefit cancer immunotherapy.

PI_NAMEs: GUO, FUKUN ;ZHENG, YI  (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: anti-cancer;Autoantibodies;Autoimmune Responses;Autoimmunity;Binding;Biochemical;Biological Assay;Blood Cell Count;Body Weight;cancer cell;cancer immunotherapy;Cancer Patient;cancer therapy;CAR T cell therapy;Catalysis;Catalytic Domain;cell mediated immune response;Cell Membrane Permeability;Cell Physiology;cell type;combat;Complex;cytokine;derepression;Dose;Drug Kinetics;effector T cell;enantiomer;exhaustion;GATA3 gene;Genetic study;Goals;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate Phosphohydrolases;Heterozygote;Homeostasis;Human;immune checkpoint;Immune checkpoint inhibitor;Immunity;Immunologic Surveillance;immunoregulation;Immunosuppression;Immunotherapy;improved;In Vitro;Inflammatory;inhibitor;lead optimization;Malignant Neoplasms;Mediating;Modeling;Molecular;Morbidity - disease rate;mortality;mouse genetics;mouse model;Mus;neoplastic cell;novel;novel strategies;Pathology;patient response;Pharmaceutical Chemistry;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacology;Play;preclinical efficacy;Property;Proteins;rational design;Regimen;Regulatory T-Lymphocyte;Reporter;Resolution;rho GTP-Binding Proteins;Role;Serum;side effect;Signal Pathway;Signal Transduction;small molecule;small molecule inhibitor;Solubility;Structure;Structure-Activity Relationship;success;T cell response;T-Cell Activation;T-Cell Depletion;T-Lymphocyte;Testing;Therapeutic;three dimensional structure;Tissues;Toxic effect;translational applications;tumor;tumor growth;Tumor Immunity;Tumor Suppression;Variant;Work

PROJECT_TITLE: Rational targeting of Cdc42 to benefit immunotherapy

STUDY_SECTION: DMPC

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology C Study Section[DMPC]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: RICHARDSON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

ORG_STATE: TX

PHR: Spinal cord injury (SCI) is debilitating neurological condition with limited treatment options, particularly long after injury. We have developed a novel strategy that uses vagus nerve stimulation during upper limb rehabilitation to improve recovery of arm and hand function. In this project, we will develop a system to apply this approach to lower limb rehabilitation and perform a randomized, double-blinded, sham-controlled, study to evaluate the potential of this approach to enhance recovery of walking function in individuals with chronic, incomplete SCI.

PI_NAMEs: HAYS, SETH ALANSON;KILGARD, MICHAEL P;RENNAKER, ROBERT L (contact);SWANK, CHAD DOUGLAS

PROGRAM_OFFICER_NAME: GROSS, BROOKS ANDREW

PROJECT_TERMS: Affect;arm function;Breakthrough device;Caring;Cervical spinal cord injury;Chronic;chronic stroke;Clinical;Clinical Data;clinical investigation;Clinical Research;clinical translation;Clinical Trials;cohort;Coupling;Data;design;Development;Devices;disability;Documentation;Double-Blind Method;effective intervention;efficacy evaluation;Electric Stimulation;Ensure;exercise rehabilitation;Family;first-in-human;Functional disorder;Gait;gait rehabilitation;Goals;Hand functions;Human Resources;human study;Implant;improved;Individual;Injury;innovation;Institutional Review Boards;Intervention;Left;Leg;Limb structure;Locomotion;Lower Extremity;Medical;miniaturize;Motor;Neck;Nervous System Disorder;Nervous System Trauma;Neurologic;Neurological Models;Neuromodulator;neuroregulation;next generation;novel strategies;Patients;Performance;Phase;Pilot Projects;pilot test;post stroke;pre-clinical;Pre-Clinical Model;Quality of life;Randomized;Recording of previous events;Recovery;Recovery of Function;Rehabilitation therapy;safety and feasibility;sensor;Sensory;sham-controlled study;Societies;Spinal;Spinal cord injury;Stroke;success;Synaptic plasticity;System;Techniques;Test Result;Testing;Training;Translating;translational therapeutics;Translations;treatment optimization;United States;Upper Extremity;vagus nerve stimulation;Walking;Work

PROJECT_TITLE: Enhancing recovery of lower limb function after spinal cord injury

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders C Study Section[NSD-C]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Hematology

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: More than 1.8 million coronary stents are placed annually. Stent thrombosis is a catastrophic mechanism and has a high mortality. Antiplatelet therapy prevents thrombosis but increases bleeding risk. We developed a stent system that provides local antiplatelet activity, obviating the need for systemic therapy to mitigate bleeding risk.

PI_NAMEs: PACELLA, JOHN J (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Accounting;Acute myocardial infarction;Adherence;Adoption;Adult;Animal Model;Anticoagulant therapy;Anticoagulation;Antiplatelet Drugs;Area;Arteries;Arteriovenous fistula;Atrial Fibrillation;bench to bedside;Blood Platelets;cardiac device;Cardiovascular Diseases;Cause of Death;Cessation of life;Chemicals;Chemistry;clinical translation;Complication;Confocal Microscopy;Coronary;Coronary artery;Coronary Stenosis;cost;Data;Devices;drug standard;Endothelium;experience;experimental study;Exploratory/Developmental Grants Phase II;Failure;Family suidae;Funding Mechanisms;hazard;head-to-head comparison;Heart Atrium;Hemorrhage;high risk;Histopathology;human subject;Implant;implantation;In Vitro;Industry Standard;Infarction;Inflammation;Interruption;Left;Legal patent;Life;life span;Mass Spectrum Analysis;Measurement;Measures;Modeling;monolayer;Morbidity - disease rate;mortality;mortality risk;multidisciplinary;Myocardial Infarction;new technology;novel;Operative Surgical Procedures;Oral;Oryctolagus cuniculus;Patients;percutaneous coronary intervention;Performance;Pharmaceutical Preparations;Pharmacologic Substance;Platelet Activation;platelet function;Population;porcine model;Positioning Attribute;prevent;Prevention;Quality of life;Recording of previous events;Recurrence;Reporting;revascularization;Risk;Safety;safety assessment;safety testing;Scanning Electron Microscopy;self assembly;Spectrum Analysis;stent thrombosis;Stents;Sterilization;success;Surface;System;Systemic Therapy;Techniques;Technology;Therapeutic Intervention;Thrombosis;Thrombus;Translating;translation to humans;ultraviolet;United States;Work

PROJECT_TITLE: A Novel Ticagrelor Coated Stent to Eliminate the Need for Dual Anti Platelet Therapy Post PCI

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-O (O1)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: Newark

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative This research will apply a mixed-methods approach to assess the use and impact of a new generation of misleading descriptors and imagery in combustible tobacco marketing. Research activities (including focus groups, a discrete choice experiment and eye tracking) will focus on identifying the effects of such marketing for cigarettes and cigarillos on attention, product appeal, and risk perceptions of current and susceptible youth and young adult tobacco users, and will inform future research and appropriate regulatory remedies.

PI_NAMEs: GRATALE, STEFANIE  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Agreement;American;Area;Attention;authority;Authorization documentation;Behavior;career;Cigarette;cigarillos;combustible tobacco;Data;Descriptor;Electronic cigarette;Evolution;experimental study;Family Smoking Prevention and Tobacco Control Act;Focus Groups;Future;Generations;Goals;Grant;health communication;Image;Imagery;Industry;Joints;Light;Literature;low nicotine content cigarette;Manufacturer;Marketing;media use;Methodology;Methods;Modified Risk Tobacco Product;Monitor;natural product inspired;Participant;Perception;Persons;Predisposition;preference;Product Packaging;public policy on tobacco;Randomized;Reaction;Regulation;Research;Research Activity;Research Personnel;research study;Review Literature;Risk;risk perception;Safety;Series;skills;Stimulus;Tobacco;tobacco advertising;tobacco control;Tobacco Industry;tobacco products;tobacco user;Training;trend;Variant;visual tracking;Water;Work;young adult;Youth

PROJECT_TITLE: A new generation of misleading tobacco marketing: Assessing the evolution of misleading combustible tobacco marketing features and detrimental implications for vulnerable youth and young adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-Q (50)]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Hematology;Orphan Drug;Rare Diseases

ORG_CITY: Cambridge

ORG_NAME: DNA MEDICINE INSTITUTE

ORG_STATE: MA

PHR: Project Narrative  Hemophilia A results from a deficiency of FVIII-activity and can result in severe bleeding. Head bleeds can be debilitating and joint-bleeds require major medical intervention. The results of our efforts will be a human-centered hemophilia Bluetooth-connected monitoring device, consumable, and app that will provide accurate and easy FVIII and FVIII-like monitoring with the goals of decreasing risk of unexpected bleeding and increasing patient care in all settings for traditional and novel therapies.

PI_NAMEs: CHAN, EUGENE YAN-HO (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Acute;age acceleration;Area;Benchmarking;Biological Assay;Birth;blind;Blinded;Blood;Blood capillaries;Blood specimen;Bluetooth;Boston;care providers;Cattle;Clinical;commercialization;cost effective;Data;design;Detection;detection limit;Development;Devices;dosage;Dose;Ensure;F8 gene;Fluorogenic Substrate;Funding;gene therapy;Genetic Diseases;Goals;Half-Life;Head;Hemophilia A;Hemorrhage;Home;Human;improved;in-vitro diagnostics;Incidence;Individual;inhibitor;innovation;Intervention;Investments;Joints;Knowledge;Laboratories;Linear Regressions;Link;male;Measurement;Measures;Medical;meter;Methods;Microfluidics;Monitor;monitoring device;Multi-Institutional Clinical Trial;normal aging;novel;novel therapeutics;Operative Surgical Procedures;Patient Care;Patients;Pediatric Hospitals;Performance;performance tests;Phase;Physical activity;point of care;point-of-care diagnostics;precision medicine;Process;Production;Reagent;recessive genetic trait;reconstitution;Regulation;Replacement Therapy;Research Contracts;Risk;risk mitigation;Running;sample collection;Sampling;Site;Specificity;Structure;success;System;Techniques;Technology;Testing;Therapeutic;Time;traditional therapy;Translating;trend;Validation;validation studies;Variant;Venous;Venous blood sampling;waiver;Work

PROJECT_TITLE: Hemophilia Point-of-Care Monitoring Device and App

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-F (O1)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: CHARLESTON

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: EASTERN ILLINOIS UNIVERSITY

ORG_STATE: IL

PHR: PROJECT NARRATIVE – Michael W. Beck, Eastern Illinois University Carboxylesterases (CESs) play a key role in the metabolism of many common drugs including aspirin, methylphenidate (Ritalin®), and remdesivir (Veklury®), the first FDA-approved drug to treat COVID-19. The overall metabolic activity of CESs, however, can be drastically different from person to person. This interindividual variability has been shown to influence the metabolism and, in some cases, clinical outcomes of patients treated with drugs that are processed by one of these CESs, CES1. This project will reveal new risk factors for ineffective treatment by CES1-substrate drugs by creating methods that can be deployed to identify drugs and genetic factors that influence CES1 activity through developing chemical probes that can specifically report on CES1 activity in live samples. This will lead to better patient outcomes upon treatment with drugs that are metabolized by CES1.

PI_NAMEs: BECK, MICHAEL WILLIAM (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: absorption;Address;Amides;Amino Acids;analog;Aspirin;Award;Biochemical Process;Biochemistry;Biological Assay;Biological Availability;Biology;Biomedical Research;Carbamates;Carbonates;carboxylesterase;Carboxylesterase 1;Cells;Cellular biology;Chemicals;Clinical;COVID-19 treatment;Data;design;Drug Delivery Systems;Drug Interactions;drug metabolism;effective therapy;Effectiveness;Endoplasmic Reticulum;Endowment;Environment;Enzymes;esterase;Esters;FDA approved;Fluorescein;Fluorescence;Fluorescent Probes;gastrointestinal system;Genetic;Genetic Polymorphism;Goals;Health;Hepatic;high throughput screening;Human;Human Activities;Hydrolase;Hydrolysis;Illinois;ineffective therapies;innovation;inter-individual variation;Interdisciplinary Study;Intestines;Knowledge;Libraries;Liver;Measures;Mediating;Metabolic;Metabolism;Methodology;Methods;Modernization;Molecular Biology;Mutation;next generation;Oral;Organic Chemistry;overexpression;Paper;Patient-Focused Outcomes;personalized therapeutic;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Play;Portal System;Process;programs;Publishing;ratiometric;remdesivir;Reporter;Reporting;Research;Risk Factors;Ritalin;Sampling;Science;Scientist;Sensitivity and Specificity;Single Nucleotide Polymorphism;Small Intestines;small molecule;small molecule therapeutics;Specificity;Structure-Activity Relationship;success;Techniques;Technology;thioester;Tissues;tool;Training;training opportunity;undergraduate student;Universities;Variant

PROJECT_TITLE: Chemical biology approaches to understand interindividual variability in carboxylesterase activity

STUDY_SECTION: CBP

STUDY_SECTION_NAME: Chemical Biology and Probes Study Section[CBP]


ORG_CITY: WORCESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Despite the increased effort to curtail e-cigarette use in young adults, the current public health communication campaign messages may fail to influence young adults’ e-cigarette harm perceptions and behavior. Vapers and non-vapers may trust different health information sources and respond differently to messages based on how they are presented, but little research has examined the effects of these communication principles. The proposed study uses online and in-lab studies (Phase 1) and a randomized trial (Phase 2) to understand the role of using an optimal source (expert and peer) and message presentation type (one sided and two sided) in e-cigarette education messages to increase young adult vapers and non-vapers’ message acceptance and change their vaping behavior.

PI_NAMEs: LEE, DONGHEE NICOLE (contact)

PROJECT_TERMS: Age;Area;arm;Arousal;Attitude;Behavior;Behavioral;biobehavior;Cigarette Smoker;cigarette smoking;Cognition Disorders;Communication;Credentialing;crowdsourcing;Data;Data Set;design;Development;Education;Electronic cigarette;electronic cigarette use;follow-up;Galvanic Skin Response;Goals;Health;health communication;Heart Rate;improved;individual response;Measures;Methods;Misinformation;Mood Disorders;Nicotine Dependence;Participant;Patient Self-Report;peer;Perception;Persons;Persuasive Communication;Phase;Population;Predisposition;prevent;Prevention;Psychology;Psychophysiology;public education;Public Health;public health priorities;Randomized;randomized trial;reduce tobacco use;Reporting;Research;Research Activity;Research Personnel;response;Role;Scientist;Side;Source;tailored text messaging;Testing;Text Messaging;text messaging intervention;theories;Tobacco;tobacco products;tobacco regulatory science;Tobacco use;tobacco user;Training;Trust;United States Food and Drug Administration;vaper;vaping;Visual attention;visual tracking;young adult

PROJECT_TITLE: Identifying and examining the effects of source and presentation on responses to electronic cigarette public education messages in young adult vapers and non-vapers


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Genetics;Human Genome;Pediatric;Regenerative Medicine

ORG_CITY: CORAL GABLES

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: NARRATIVE  The different cellular compartments of the pancreas have a high degree of plasticity, which, if harnessed, could have important therapeutic applications for beta cell regeneration in type 1 and 2 diabetes. We have discovered stem-like cells in the human pancreas that respond to a naturally occurring growth factor, BMP-7, by proliferating and subsequently differentiating into adult pancreatic cell types, including insulin-producing beta cells. Our proposal aims at the dissection of this phenomenon at the single-cell level using unique samples from type 1 diabetic donors, termed “human pancreatic slices”. These studies are highly relevant to the mission of the National Institutes of Health and may ultimately have a significant impact on public health.

PI_NAMEs: DOMINGUEZ-BENDALA, JUAN  (contact);PASTORI, RICARDO L

PROGRAM_OFFICER_NAME: ZAGHLOUL, NORANN

PROJECT_TERMS: Adopted;Adult;Agonist;Anatomy;Appearance;Architecture;Autoimmune Diabetes;B-Lymphocytes;Basic Science;Beta Cell;BMPR1A gene;bone morphogenetic protein receptors;Cell Differentiation process;cell regeneration;cell type;Cells;Characteristics;Collection;Complement;Coupling;Culture Techniques;Cyclic Peptides;Data;Data Set;design;Development;developmental plasticity;diabetic;Diabetic mouse;diabetic patient;Dissection;Duct (organ) structure;Ductal Epithelial Cell;Ductal Epithelium;Embryo;Embryonic Development;Endocrine;Epithelial Cells;Exhibits;experimental study;Exposure to;Glucose;Growth;Growth Factor;Histologic;histological specimens;Human;human model;Hyperglycemia;Image;imaging platform;immunodeficiency;In Vitro;Insulin;Insulin-Dependent Diabetes Mellitus;Interruption;islet;Longterm Follow-up;Manuscripts;Mediating;migration;Mission;mouse model;movie;Mus;Natural regeneration;Neomycin resistance gene;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Organ;Pancreas;Pancreatic duct;Population;Population Dynamics;Positioning Attribute;Preparation;preservation;Process;progenitor;Proliferating;Public Health;regeneration potential;regenerative;Regenerative response;Regimen;Research;Research Support;Resolution;response;Route;Sampling;self organization;Signal Induction;Signal Transduction;single-cell RNA sequencing;Slice;Sorting;stem cell population;stem cells;stem-like cell;Stimulus;Technology;Testing;Therapeutic;Time;Tissues;transcriptomics;Transplantation;type I diabetic;United States National Institutes of Health;virtual

PROJECT_TITLE: BMP signaling and regenerative plasticity: Correlating dynamic scRNAseq and real-time anatomical remodeling in T1D pancreatic slices

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-W (O2)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: Columbus

ORG_DEPT: PSYCHIATRY

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Deficits in social cognition are highly common in mid- and late-life schizophrenia spectrum disorders, significantly contribute to difficulties functioning in the community, and are very difficult to treat. The goals of this study are to characterize social cognitive deficits, evaluate their trajectories in relation to normal and pathological aging, and discover neural markers underlying individual differences in these deficits in mid-late life schizophrenia spectrum disorders. The results of this study are expected to guide the development of better patient stratification strategies and targeted treatment interventions that improve social functioning for individuals living with chronic schizophrenia spectrum disorders.

PI_NAMEs: TSO, IVY FEI (contact)

PROGRAM_OFFICER_NAME: ROWLAND, LAURA

PROJECT_TERMS: Affective;Age;age related changes;age related decline;Age-associated memory impairment;Aging;Area;base;Behavioral;Bilateral;biological heterogeneity;Biological Markers;biotypes;Brain;Cephalic;Chronic;Chronic Phase;Chronic Schizophrenia;Clinical;Cognitive;Cognitive deficits;cognitive task;Communities;comorbidity;Coupling;Data;Development;Dimensions;Disease;early psychosis;effective intervention;Electroencephalography;Emotions;Event;excitatory neuron;Female;first episode psychosis;Frequencies;functional disability;functional outcomes;functional restoration;Goals;Heterogeneity;Impaired cognition;Impairment;improved;improved outcome;Individual;Individual Differences;inhibitory neuron;Intervention;Knowledge;late life;life span;machine learning model;Medical;Mental disorders;Methodology;middle age;National Institute of Mental Health;neural;Neurobiology;Neurocognition;neuromechanism;neurophysiology;noninvasive brain stimulation;normal aging;Parietal;Participant;Pathologic;pathological aging;patient stratification;Patients;Perception;personalized intervention;personalized medicine;Persons;Phase;Phenotype;poor communities;Process;recruit;Research Priority;response;Rest;Sampling;Schizophrenia;schizophrenia spectrum disorder;social;social cognition;Social Functioning;supervised learning;targeted treatment;Task Performances;therapy development;Theta Rhythm;Time;treatment strategy

PROJECT_TITLE: Progression of Social Cognitive Deficits in Mid- and Late-Life Schizophrenia Spectrum Disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-S (06)]


ADMINISTERING_IC: AR

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Nutrition;Physical Activity;Prevention

ORG_CITY: BLACKSBURG

ORG_DEPT: NUTRITION

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE: Exercise promotes skeletal muscle health resulting in protection from disease; however, the cell signaling required for these benefits remains unclear. The skeletal muscle is made up of multiple cell types which need to "talk" to each other to coordinate their activities so that the skeletal muscle can support the increased energy demand of exercise. This proposal seeks to understand the underlying signaling by the vascular endothelium required for the beneficial skeletal muscle responses to exercise.

PI_NAMEs: CRAIGE, SIOBHAN M (contact)

PROGRAM_OFFICER_NAME: EISENSTEIN, JANA S

PROJECT_TERMS: Acute;Address;Affect;Automobile Driving;Bioenergetics;Biogenesis;cell type;Cells;Coculture Techniques;Complex;Data;Development;Diet;Disease;Endothelial Cells;Endothelium;Enzymes;Essential Fatty Acids;Excision;Exercise;exercise intervention;experimental study;fatty acid oxidation;Foundations;Gene Expression;genetic manipulation;Goals;Health;Health Promotion;Imaging Device;Immune;Impairment;improved;In Vitro;in vivo;in vivo Model;individualized medicine;innovation;insight;Investigation;Knowledge;Link;Liver;Measures;Mediating;Medicine;Membrane Potentials;Metabolic;Metabolism;Mitochondria;mitochondrial membrane;mitochondrial metabolism;Molecular;Mus;Muscle Cells;Muscle Fibers;muscle metabolism;Myopathy;NADPH Oxidase;NG-Nitroarginine Methyl Ester;Nitric Oxide;Nitric Oxide Synthetase Inhibitor;NOS3 gene;novel;paracrine;Paracrine Communication;Pathway interactions;Pericytes;pharmacologic;Phenocopy;prevent;Production;programs;protective effect;protein expression;Quality Control;Reactive Oxygen Species;Research;Resolution;response;Role;Series;Signal Transduction;Skeletal Muscle;skeletal muscle metabolism;Stress;System;Time;tool;treatment strategy;Vascular Endothelial Cell;Vascular Endothelium

PROJECT_TITLE: Endothelial Signaling in Exercise Metabolism

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: SAN JUAN

ORG_NAME: INTER AMERICAN UNIVERSITY/PUERTO RICO

ORG_STATE: PR

PHR: PROJECT NARRATIVE The Centers for Disease Control and Prevention (CDC) designates methicillin-resistant Staphylococcus aureus (MRSA) as a serious concern that requires prompt attention because it causes approximately 323,700 infections per year in the US, resulting in 10,600 deaths and an estimated $1.7 billion in total healthcare costs. Synthetic unsaturated fatty acids (uFAs) are attractive candidates to become next-generation antibacterial agents for treating MRSA infections because they can directly kill multi-drug resistant bacteria at very low concentrations. This project will provide the chemical and biological foundations needed for the targeted design of new novel therapeutic options to treat devastating MRSA infections.

PI_NAMEs: SANABRIA, DAVID  (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: Acids;Address;American;Anabolism;Anti-Bacterial Agents;Antibiotics;Attention;Bacteria;Biological;Biological Assay;Biomedical Research;Bromides;Carbon;Cell membrane;Cell Survival;Centers for Disease Control and Prevention (U.S.);Cessation of life;Chemicals;Communities;Consumption;Critical Thinking;cytotoxic;Data;design;Development;DNA;Docking;drug resistant bacteria;Electron Microscopy;experimental study;Extravasation;Flow Cytometry;Foundations;Goals;Health Care Costs;health care settings;hospital care;Hospitalization;improved;In Vitro;Infection;insight;interest;Knowledge;Knowledge acquisition;Length;Lipids;Mass Fragmentography;Membrane;Membrane Potentials;methicillin resistant Staphylococcus aureus;metropolitan;minority undergraduate;Molecular;Multiple Bacterial Drug Resistance;muramyl-NAc-(pentapeptide)pyrophosphoryl-undecaprenol;nanomolar;next generation;Nisin;novel;novel therapeutics;oral communication;palmitoleic acid;Patients;Peptidoglycan;Peptidyltransferase;Phospholipids;pi bond;Probability;Property;Puerto Rico;rational design;Research;Resistance;Resistance development;RNA;Role;Scanning Electron Microscopy;skills;Staphylococcus aureus;Staphylococcus aureus infection;Superbug;Testing;undergraduate student;United States;Universities;unsaturated bonds;Unsaturated Fatty Acids;Western Blotting;Writing

PROJECT_TITLE: Investigating the mechanism of action of antibacterial synthetic unsaturated fatty acids in methicillin-resistant Staphylococcus aureus

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: GSDMs are associated with many human diseases, and deletion of GSDMD significantly decreases pyroptosis and IL-1β secretion, and remarkably protects mice from sepsis. By contrast, activation of GSDMs enhances pyroptosis and may promote anti-tumor immunity. Thus, identification of small molecule GSDM agonists to “engineer” tumor cell death for antigen presentation and for priming the adaptive immune system will have significant impact on potential therapeutics against cancer.

PI_NAMEs: LIEBERMAN, JUDY ;WU, HAO  (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: 3-Dimensional;Adaptive Immune System;adaptive immunity;Agonist;Alkynes;analog;anti-PD-1;Antigen Presentation;Antineoplastic Agents;Apoptosis;Azides;Binding Proteins;Biochemical;Biotinylation;Breast Cancer Model;cancer cell;cancer immunotherapy;Cancer Patient;cancer therapy;cancer type;CAR T cell therapy;carcinogenesis;CASP1 gene;Caspase;Cell Death;cell killing;Cell membrane;Cells;cellular imaging;Chemistry;Colorectal Cancer;Combined Modality Therapy;Complex;Cryoelectron Microscopy;cytokine;Data;Engineering;Family;Genetically Engineered Mouse;HMGB1 gene;Human;human disease;Immune;immune checkpoint blockade;Immune response;Immune system;Immunity;Immunocompetent;Immunocompromised Host;immunogenic;immunogenic cell death;Immunologic Surveillance;Immunomodulators;Implant;in vivo;Inflammasome;Inflammation;Inflammation Mediators;Inflammatory;Interleukin-1;Interleukin-1 beta;Knock-out;Laboratories;Malignant Breast Neoplasm;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;meter;Microfluidics;Minority;Modeling;mouse model;Mus;N-terminal;Natural Immunity;neoplastic cell;Normal tissue morphology;Outcome;pathogen;Pharmaceutical Chemistry;Pharmaceutical Preparations;Physiologic pulse;Process;Property;Propidium Diiodide;response;Sampling;screening;Sepsis;Series;Signal Transduction;small molecule;spheroids;Stains;Streptavidin;Structure;subcutaneous;synergism;System;T cell response;T-Lymphocyte;Testing;Therapeutic;tool;Toxic effect;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor-Infiltrating Lymphocytes;Vaccination

PROJECT_TITLE: Activating gasdermin pores to induce pyroptosis and stimulate anti-tumor immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 TIR-W (01)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases

ORG_CITY: LA CROSSE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN LA CROSSE

ORG_STATE: WI

PHR: Project Narrative High amounts of copper ions are toxic to living cells, a property that enables copper ions to kill bacterial pathogens in healthcare facilities and to contribute to human immune defenses. However, bacterial resistance to copper ions threatens their effective use as an antimicrobial metal in environmental settings and in immune control of infectious diseases. Therefore, this proposal seeks to understand a newly identified copper resistance protein in medically relevant bacteria to inform the antimicrobial use of copper in healthcare facilities and to aid in the development of strategies to target bacterial resistance to metal ions.

PI_NAMEs: MAY, JOHN  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Address;Affect;Amino Acids;anti-microbial drug;Antibiotics;antimicrobial;Bacteria;bacterial resistance;beta pleated sheet;Biochemical;Biochemistry;Biological;Biomedical Research;Biophysics;Cell Physiology;Cells;Communicable Diseases;Copper;Development;drug development;Education;Enterobacteriaceae;Environment;Enzymes;Escherichia coli;Etiology;Eukaryota;experimental study;Family;foodborne illness;Future;Genetic;Goals;Gram-Negative Bacteria;Health;Health care facility;healthcare-associated infections;Human;human pathogen;Immune;Immune system;insight;Institution;Ions;Klebsiella pneumoniae;Knowledge;Length;Lipoproteins;Macrophage;Mediating;Medical;Membrane;Metals;Molecular Genetics;N-terminal;Names;Nosocomial Infections;novel;Nutrient;Organism;Outcome;Oxidation-Reduction;pathogen;pathogenic bacteria;pathogenic microbe;Physiological;Plague;prevent;Prokaryotic Cells;Property;protein folding;Proteins;Public Health;Reaction;Research;research study;Resistance;Role;Salmonella;Salmonella enterica;Salmonella typhimurium;Site-Directed Mutagenesis;structural biology;Structure;Structure-Activity Relationship;Surface;Thermodynamics;three dimensional structure;Touch sensation;Toxic effect;toxic metal;undergraduate research;undergraduate research experience;undergraduate student;Work;X-Ray Crystallography;Yersinia pestis

PROJECT_TITLE: Structure and Function of DcrB, an Enterobacterial Copper Resistance Protein

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Bioengineering;Lung

ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: PROJECT NARRATIVE Acute and chronic air leaks resulting from lung injury or disease can result in significant mortality, morbidity, and healthcare costs, and can be difficult to treat resulting in a critical unmet need for new therapeutic approaches. We have developed a new pleural sealant (lung bandaid) and have compelling pre-clinical data in small and large animal models of pleural injury. The goal of the current proposal is to continue to develop further data in support of engagement with the FDA to develop an IND for initial clinical investigation.

PI_NAMEs: WEISS, DANIEL J (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Acute;Adhesives;Adult;Air;Alginates;Animal Model;Caring;Categories;Chest Tubes;Chronic;clinical development;clinical investigation;Critical Illness;Cyanoacrylates;Data;design;Development;Devices;Disease Management;Dopamine;Drainage procedure;efficacy evaluation;efficacy research;Elasticity;Excision;Family suidae;FDA approved;Fibrin;Fistula;Glues;Goals;Guidelines;Health Care Costs;Human;in vivo;industry partner;Injury;Intervention;Length of Stay;Life;Lung;Lung Diseases;lung injury;manufacture;Measures;mechanical properties;Mechanical ventilation;Medical Device;meetings;Methacrylates;Modeling;Modification;Morbidity - disease rate;mortality;novel;novel therapeutic intervention;Operative Surgical Procedures;Pleural;Pneumothorax;pre-clinical;preclinical study;preservation;programs;Property;prototype;Quality Control;Rattus;Recommendation;repaired;Reporting;Reproducibility;Research;Safety;Schedule;seal;sealant;Seaweed;Sterilization;Surface;System;Testing;Trachea;Trauma;United States National Institutes of Health;Work;wound

PROJECT_TITLE: Continued Clinical Development of a Novel Pleural and Tracheal Sealant

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-O (O2)]


ADMINISTERING_IC: DC

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Rehabilitation;Stroke

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative Auditory attention is not addressed by aphasia treatment programs because there are no reliable assessments of it. The purpose of this study is to develop a task that reliably measures three separate types of auditory attention in people with aphasia. The findings from this project will lay the foundation for the inclusion of auditory attention targets in aphasia treatment programs, which will subsequently improve how well people with aphasia respond to treatment.

PI_NAMEs: LACROIX, ARIANNA  (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Address;Alzheimer's Disease;Aphasia;aphasia recovery;Assessment tool;Attention;Attentional deficit;Auditory;Clinical;Cognition;Cognitive;Cognitive deficits;cognitive function;comparison control;Comprehension;Conscious;Cues;Data;Disease;Effectiveness;executive function;Experimental Models;Foundations;Frequencies;Future;health related quality of life;Hearing Tests;Impairment;improved;Knowledge;Language;language comprehension;Language Disorders;language outcome;Left;Linear Regressions;Malignant Neoplasms;Measures;National Institute on Deafness and Other Communication Disorders;neural;older adult;Participant;Performance;Persons;Process;Production;prognostic indicator;Property;Psychometrics;Reaction Time;Recovery;Resources;response;Semantics;Short-Term Memory;sound;stem;Stimulus;Stroke;stroke-induced aphasia;syntax;Taxes;Testing;Time;tool;treatment program;treatment response;verbal;Visual;Visual attention;Visuospatial;Work;young adult

PROJECT_TITLE: Optimizing the assessment of auditory attention in aphasia

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Dementia;Genetics;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Prevention;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: Narrative Individuals with psychotic disorders, such as schizophrenia and bipolar disorder, are at a very high risk of premature cognitive decline and early dementia. However, reasons for this are unclear. The current proposal aims to understand this cognitive decline by following people with psychotic disorders and never psychotic individuals across the midlife.

PI_NAMEs: JONAS, KATHERINE G;KOTOV, ROMAN I (contact)

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: Address;Adult;Age;Anti-Cholinergics;Antipsychotic Agents;apolipoprotein E-4;Behavioral;Biological;biomarker development;Bipolar Disorder;Blood;case control;Cognition;Cognition Disorders;Cognitive;cognitive change;cognitive testing;cohort;County;Data Set;Dementia;dementia risk;Deterioration;Development;Diagnosis;disability;early onset;Education;Electroencephalography;Enrollment;epidemiology study;Equilibrium;Evaluation;experience;Exposure to;first episode psychosis;follow-up;Future;General Population;Genetic;Genetic Predisposition to Disease;Genotype;Health;high risk;human old age (65+);Impaired cognition;Impairment;Incidence;Individual;Intervention;late life;Life;Light;Longitudinal Studies;Maintenance;Medical;Mental Health;Metabolic;Metabolic syndrome;middle age;modifiable risk;Molecular;Nature;Nerve Degeneration;neural;neurofilament;Outcome;Participant;Patients;performance tests;Persons;Pharmaceutical Preparations;Physical activity;physical impairment;physical inactivity;Physical Performance;Plasma;polygenic risk score;Population;premature;prevent;Prevention strategy;preventive intervention;Psychoses;psychotic;Psychotic Disorders;Publications;Race;Research;Risk Factors;Role;Schizophrenia;Self Care;Sex Differences;Smoking;social;Testing;Tobacco use

PROJECT_TITLE: Trajectories and Determinants of Cognitive Decline in Psychotic Disorders Over 35 Years


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Aging;Bioengineering;Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Immunotherapy;Orphan Drug;Rare Diseases

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative Head and neck cancers rank among the deadliest and most diagnosed cancers globally. Treatment strategies for head and neck cancers are limited, with emerging therapies, such as cancer immunotherapies, showing promising but heterogeneous responses that are poorly understood. This study focuses on understanding how aging-associated changes in the tumor microenvironment contribute to the immune evasive behavior of oral cancer, with the goal of improving clinical outcomes for patients.

PI_NAMEs: KUKURUZINSKA, MARIA A.;MONTI, STEFANO ;VARELAS, XARALABOS  (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Affect;Age;age effect;age related;age related changes;Age Years;aged;Aging;aging related;Alcohols;Anatomy;animal old age;Architecture;Areca;base;Behavior;Binding;cancer cell;cancer diagnosis;cancer immunotherapy;Carcinogens;Cell Physiology;Cells;chemokine;chemotherapy;Chronic;Chronology;Clinical;Collagen;crosslink;CXCL10 gene;CXCL9 gene;Data;defined contribution;Development;Diagnosis;Elastic Tissue;Elderly;Enzymes;Epigenetic Process;Etiology;Exhibits;Exposure to;Extracellular Matrix;Family;Fibrosis;Gene Expression;Genetic;Genetic Transcription;Goals;Habits;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Human;Human Papillomavirus;Immune;Immune checkpoint inhibitor;Immune Evasion;Immune response;Immunologic Stimulation;Immunotherapy;improved;insight;irritation;Isogenic transplantation;juvenile animal;Link;LOX gene;Lymphocyte;Lymphocyte Function;Lymphocytic Infiltrate;malignant mouth neoplasm;Malignant Neoplasms;Mastication;mechanical properties;mechanical signal;Mechanics;Mediating;Modeling;Molecular;Morbidity - disease rate;mouth squamous cell carcinoma;Mus;neoplastic cell;novel;novel therapeutics;Nuclear;Nuts;old mice;older patient;Operative Surgical Procedures;Oral;oral behavior;Oral cavity;oral tissue;Orthoptics;Patient-Focused Outcomes;Patients;permissiveness;Pharmacological Treatment;Phenotype;Play;pro-aging;programs;Radiation therapy;recruit;Repression;response;RUNX1 gene;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Specimen;Squamous cell carcinoma;Survival Rate;T-Lymphocyte;Testing;therapeutic target;Tissues;Tobacco use;Tongue;Tooth structure;Toxin;transcription factor;treatment strategy;tumor;Tumor Escape;tumor growth;tumor microenvironment;Tumor-Derived;Tumor-Infiltrating Lymphocytes;tumorigenesis;tumorigenic;Virus Diseases;Xenograft Model

PROJECT_TITLE: Defining immune-evasive mechanical signaling in head and neck cancer

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative This project aims to understand the mechanisms by which neurons in the brain regions supporting arm movements communicate with neurons in brain regions supporting eye movements during coordinated behaviors, such as looking and reaching toward an object. We will deploy neural ensemble recordings and behavioral manipulations in non-human primates to dissociate two components of multiregional communication - channel gain and channel modulation. Understanding how channel gain and modulation combine in the mechanisms of multiregional communication will lead to new strategies for neural rehabilitation and support the development of neural prosthetic systems.

PI_NAMEs: PESARAN, BIJAN  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: arm;arm movement;Attention;attentional control;Behavior;Behavior Control;Behavioral;behavioral study;Brain;Brain region;cognitive process;Communication;design;Dissociation;experimental study;Eye Movements;flexibility;gaze;Goals;grasp;Hand;human subject;improved;Link;Mediating;Modeling;Movement;neural;neural model;neural prosthesis;neurodevelopment;neuromechanism;Neurons;nonhuman primate;Ocular Fixation;Outcome;Parietal;Performance;Play;Population;Population Dynamics;Prefrontal Cortex;Preparation;Primates;Process;Property;Reaction Time;Rehabilitation therapy;response;Rest;Role;Saccades;sample fixation;System;Task Performances;Testing;Time;transmission process;Visual;Work

PROJECT_TITLE: Neural mechanisms of multiregional communication during coordinated visual behavior

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Lung;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Narrative Pulmonary fibrosis is a severe, relentless condition in which lung tissue scarring leads to worsening shortness of breath and lung dysfunction, usually leading to death within several years of diagnosis. In this project, we will use existing and newly generated mouse models of pulmonary fibrosis and human lung samples from pulmonary fibrosis patients to explore the potential utility of a gene therapy approach called AAV-SPL to treat pulmonary fibrosis. The results of this study will set the stage for further development of AAV-SPL gene therapy as a potential one-time treatment for pulmonary fibrosis.

PI_NAMEs: SABA, JULIE D (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Acceleration;Address;adeno-associated virus 9 delivery;Affect;Aftercare;Age;age related;age-related disease;alveolar type II cell;antagonist;Attenuated;Autoimmune Diseases;Award;Biological Availability;Bleomycin;Breeding;cancer risk;Cells;cellular targeting;Cessation of life;Characteristics;Chemistry;Chronic;Clinical;Clinical Trials;Collagen;cytokine;Data;Dependovirus;Development;Development Plans;Diagnosis;direct application;Disease;Dose;Drug Targeting;Drug usage;efficacy validation;Epithelial Cells;Exhibits;Family;Fibrosis;fibrotic lung;Functional disorder;Funding;Future;G-Protein-Coupled Receptors;gene therapy;Genes;Hand;Human;Hydroxyproline;idiopathic pulmonary fibrosis;Immunosuppression;indium-bleomycin;Inflammation;Intravenous;intravenous injection;Knockout Mice;Liver;Lung;Lung Diseases;Lung Transplantation;manufacture;Marketing;Measures;Mediating;meetings;Metabolism;Modeling;mouse model;Mus;Neurodegenerative Disorders;novel;older patient;Pathway interactions;Patients;Performance;Persons;pharmacologic;Phase;Play;Positioning Attribute;pre-clinical;Preparation;Preventive;Profibrotic signal;Proteins;Pulmonary Fibrosis;pulmonary function decline;Regimen;Role;Safety;Sampling;Satellite Viruses;Shortness of Breath;Signal Pathway;Signal Transduction;Slice;Sphingolipids;sphingosine 1-phosphate;sphingosine-1-phosphate lyase;Sphingosine-1-Phosphate Receptor;success;Tamoxifen;telomere;Telomeric Repeat Binding Protein 1;Therapeutic;Therapeutic Agents;Tissues;Toxicology;transgene expression;United States Food and Drug Administration;Virus

PROJECT_TITLE: Adeno-associated virus-mediated SGPL1 gene therapy as a first-in-class treatment for idiopathic pulmonary fibrosis that acts by reducing sphingosine-1-phosphate and downstream profibrotic signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-F (O2)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Adolescent Sexual Activity;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Recovery Support Services;Social Determinants of Health;Substance Misuse;Underage Drinking;Violence Against Women;Violence Research;Women's Health Research;Youth Violence

ORG_CITY: CHARLOTTE

ORG_NAME: UNIVERSITY OF NORTH CAROLINA CHARLOTTE

ORG_STATE: NC

PHR: Narrative: Sexual and gender minority (e.g. lesbian, gay, bisexual, trans, queer; SGM) emerging adults (18-25 years) experience sexual violence at a rate nearly double that of their heterosexual, cisgender peers. SGM emerging adults who receive a negative social reaction after disclosure of SV have increased levels of hazardous drinking as well as negative mental health outcomes. To decrease excessive alcohol use and improve mental health among SGM survivors of sexual violence, we will reconstruct an existing intervention (SSS), with promising but mixed effects in an initial pilot, to be delivered to SGM emerging adults, which aims to improve the social reaction they provide to SGM survivors of sexual violence.

PI_NAMEs: MOXIE, JESSAMYN  (contact)

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: acceptability and feasibility;Advocate;Age;Alcohol abuse;Alcohol consumption;Alcohols;Area;attentional control;Behavior;behavior prediction;career;cisgender;college;Communities;Data;design;Disclosure;Disparity;drinking;Educational workshop;emerging adult;Enrollment;Evaluation;experience;Face;Feedback;Frequencies;Friends;Goals;Grant;hazardous drinking;Health;Health Occupations;Health Personnel;Heterosexuals;Hour;improved;Individual;Intervention;Lead;Lesbian Gay Bisexual;Lived experience;Measures;member;Mental Depression;Mental Health;Mentors;Methodology;minority stress;Outcome;Participant;patient engagement;Pattern;peer;peer support;Persons;Planning Theory;Post-Traumatic Stress Disorders;preference;programs;queer;Questionnaires;Randomized;Reaction;reconstruction;recruit;Research;Research Assistant;revictimization;Sampling;satisfaction;Sexual and Gender Minorities;sexual violence;Sexual violence prevention;skills training;social;Stigmatization;Structure;Students;Survivors;Techniques;Testing;Training;undergraduate research;university student;Video Recording;Vulnerable Populations

PROJECT_TITLE: Reconstruction of an SGM-specific sexual violence peer support program (SSS+)

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Prevention;Primary Health Care;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE South Asia has the highest suicide rate in the world with important risk profile differences from high-income settings. We will conduct formative research to identify barriers and facilitators to uptake and fidelity of suicide module of the mental health gap action programme and adapt a package of strategies to optimize its use in primary care health facilities to test in a pilot feasibility cluster randomized controlled trial in Nepal. Potential health impacts may be substantial as results can be applied not only in similar South Asian primary healthcare contexts, but also in low-resource settings in the US and abroad, where the suicide burden remains high.

PI_NAMEs: HAGAMAN, ASHLEY K (contact);SAPKOTA, SABITRI

PROGRAM_OFFICER_NAME: VEDHAM, VIDYA

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adoption;Asia;Behavior;brief intervention;care systems;Caring;China;Clinical;Clinical effectiveness;Communities;community advisory board;Community Health Aides;Competence;Country;Decentralization;design;Detection;digital monitoring;digital platform;Disadvantaged;District Hospitals;Educational workshop;effectiveness outcome;Elements;Ethics;Ethnography;evidence base;Evidence based program;Feasibility Studies;feasibility trial;Feeling suicidal;follow-up;formative assessment;Funding;Future;future implementation;gaps in access;Government;Health;Health care facility;health care model;Health Personnel;Health system;health training;Healthcare;Healthcare Systems;Hospitals;Household;Hybrids;ideation;implementation framework;implementation outcomes;implementation protocol;implementation strategy;implementation/effectiveness;improved;Income;India;Individual;Infrastructure;Interview;Link;low and middle-income countries;Maintenance;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Methods;Modeling;Monitor;mortality;Nepal;Patient-Focused Outcomes;Patients;Perception;Persons;Pilot Projects;pilot test;population health;post-COVID-19;Prevalence;Prevention approach;Prevention strategy;Primary Care;primary care patient;primary care provider;primary care services;Primary Health Care;Process;programs;Protocols documentation;Provider;Quality of Care;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Research;Research Personnel;Resource-limited setting;Resources;Risk;Rural;Safety;screening;Screening procedure;secondary outcome;Severities;social stigma;South Asian;Structure;success;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide prevention;suicide rate;Supervision;System;Testing;tool;Training;Training Programs;uptake;Violence;Work

PROJECT_TITLE: Integrating a suicide prevention package of strategies into decentralized primary health care systems: an implementation pilot study in rural Nepal

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-N (07)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Lung;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

ORG_CITY: IOWA CITY

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Narrative Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) causes substantial morbidity and mortality in humans. It has become apparent that, even as most people have developed an immune response to the virus either from infection or vaccination, long term sequelae of the infection will be a burden on human health for years to come. This project will examine long term effects of the infection in the olfactory system and brain, with the ultimate goal of identifying novel therapeutic targets.

PI_NAMEs: PERLMAN, STANLEY  (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 1918 influenza pandemic;2019-nCoV;Acute;acute COVID-19;acute infection;Address;Affect;Animal Experiments;Anosmia;Autopsy;behavior test;Behavioral;Biological Assay;Body System;Brain;brain fog;Cell Physiology;Cells;Chronic;Clinical;common symptom;COVID-19;COVID-19 pandemic;Death Rate;Defect;Development;Disease;Electrophysiology (science);Encephalitis Lethargica;experimental study;Functional disorder;Gastrointestinal tract structure;Gene Expression;gene function;Goals;Health;Hematogenous;Human;hyposmia;Immune response;Immunologics;Impaired cognition;Individual;Infection;Infiltration;Inflammation;Inflammatory;Inflammatory Infiltrate;Label;Long-Term Effects;long-term sequelae;Lung;Measurement;Molecular;Morbidity - disease rate;mortality;Mus;Myelogenous;Myeloid Cells;Nasal cavity;Nervous System Disorder;Nervous System Physiology;Neurodegenerative Disorders;Neurologic;Neurologic Dysfunctions;Neurologic Symptoms;Neurons;Neurotransmitters;new therapeutic target;olfactory bulb;Olfactory dysfunction;Olfactory Epithelium;Olfactory Pathways;olfactory sensory neurons;Operative Surgical Procedures;Organ;Paraosmias;Parkinson Disease;Patients;Persons;Post-Acute Sequelae of SARS-CoV-2 Infection;Recovery;Residual state;Resolution;Respiration Disorders;Respiratory Disease;Respiratory System;Role;Running;SARS-CoV-2 infection;Sensory;Signal Transduction;Site;Smell Perception;Substantia nigra structure;Supporting Cell;Survivors;sustentacular cell;System;T-Lymphocyte;Time;Tissues;transmission process;Vaccinated;Vaccination;Viral;Viral Antigens;Viral Proteins;viral RNA;Virus

PROJECT_TITLE: Olfactory and neurological manifestations of acute and post-acute murine COVID-19

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: The prognosis for GBM patients remains dismal and there is an urgent unmet need for novel therapies. The first oncolytic virus to be approved by the FDA is an oncolytic HSV whose use is prescribed for melanoma patients is HSV-1 derived. Japan has also recently conditionally approved use of an oncolytic HSV for GBM patients. Thus, there is a lot of interest in developing this treatment modality. We propose to create and optimize a mouse model that will be sensitive for HSV-1 and recapitulates genetic background of brain tumors, in an immune competent mouse model.

PI_NAMEs: HONG, BANGXING B;KAUR, BALVEEN  (contact)

PROGRAM_OFFICER_NAME: DHRUV, NEEL TUSHAR

PROJECT_TERMS: Alternative Therapies;Animal Model;Animals;Biological;Biological Response Modifier Therapy;Brain Neoplasms;CD34 gene;Cell Separation;Cells;chemotherapy;Cytolysis;Cytomegalovirus;design;Development;Devices;Disease;efficacy testing;Endothelial Cells;Environment;Europe;Evaluation;Exons;Extracellular Matrix;FDA approved;G207;Generations;Genes;Genetic;Glioblastoma;Glioma;Goals;Hematopoietic stem cells;Herpesvirus 1;Human;humanized mouse;Immune;Immune system;Immune Tolerance;Immunocompetent;immunodeficiency;immunogenic;immunosuppressed;Immunotherapy;in vitro Model;in vivo;Infection;interest;Japan;Knock-in;Laboratories;Marketing;Melanoma patient;Metastatic Melanoma;Microglia;Modality;Modeling;mouse model;Mus;mutant;Mutation;Nature;neoplastic cell;nerve stem cell;novel;novel therapeutics;Oncolytic;oncolytic virotherapy;Oncolytic viruses;Operative Surgical Procedures;Patients;permissiveness;Phase;pre-clinical;Primary Brain Neoplasms;Prognosis;promoter;PVRL1;Radiation;Radiation therapy;reconstitution;Recurrence;Reproducibility;response;Safety;safety testing;Simplexvirus;Solid Neoplasm;stem-like cell;Study models;temozolomide;Testing;Transgenes;Transgenic Mice;Transplantation;Treatment Efficacy;tumor;tumor eradication;tumor growth;Tumor Immunity;tumor microenvironment;Tumorigenicity;Viral;Virus;Virus Diseases

PROJECT_TITLE: Development of murine glioblastoma model for oncolytic HSV therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-M (16)]


ADMINISTERING_IC: ES

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Climate-Related Exposures and Conditions;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: Boulder

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: Project Narrative Issues investigated in this project are of considerable importance to public health as air pollution is both a widespread yet modifiable risk factor for mental illness. By better understanding the long-term neuropsychiatric effects of PM2.5 exposure, including the specific aspects of psychopathology and the brain that are most affected from developmental exposure, we may gain insight into the full societal burden of air pollution while also identifying neural and molecular targets for interventions aimed at ameliorating adverse effects of exposure.

PI_NAMEs: SMOLKER, HARRY R (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Address;Adult;Adverse effects;Affect;Air Pollutants;Air Pollution;Automobile Driving;base;Biological;Birth;Brain;cardiovascular health;Central Nervous System;Childhood;Clinical;Cognitive;Data;Development;Diagnosis;Diagnostic;Dimensions;Discipline;Environmental Risk Factor;Equation;experience;Exposure to;fine particles;Future;gene environment interaction;Genetic;genetic analysis;Genetic Risk;genetic risk factor;Genetic Techniques;Goals;Growth;Immune response;Individual;Individual Differences;Inflammation;innovation;insight;Intervention;knowledgebase;lens;Life;life span;Link;Literature;Long-Term Effects;longitudinal dataset;Magnetic Resonance Imaging;Measures;Mental disorders;Mental Health;mental health epidemiology;Methodology;Microglia;Modeling;modifiable risk;Molecular Genetics;Molecular Target;multimodality;Nature;Nerve Degeneration;neural;neural correlate;Neuroanatomy;neuroimaging;Neuroimmune;neuropsychiatry;novel;Outcome;Outcome Assessment;Outcomes Research;Oxidative Stress;Participant;Particulate;Pathway interactions;Perinatal Exposure;perinatal period;Phenotype;polygenic risk score;Predisposition;programs;Property;psychologic;Psychopathology;Public Health;Public Policy;Qualifying;remediation;Research;Research Personnel;respiratory health;response;Risk;Risk Factors;Sampling;Severities;Sex Differences;skills;Specialist;Symptoms;System;Targeted Research;Techniques;Testing;Time;Toxic Environmental Substances;trait;young adult

PROJECT_TITLE: Long-term Effects of Developmental Air Pollution Exposure on Adult Mental Health: Sensitive Periods, Neural Correlates, and Genetic Risk Factors

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 VSM-S (PD)]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Triple-negative breast cancer (TNBC) is considered the most aggressive subtype of breast cancer, and patients with TNBC exhibit a poor prognosis, despite current treatment regimens. Here, we seek to decipher a novel oncogenic function of TAZ on tumor microenvironment in TNBC progression and may provide opportunities for novel biomarker or therapeutic target discovery.

PI_NAMEs: ZHANG, JIANMIN  (contact)

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: adaptive immune response;angiogenesis;B-Lymphocytes;Biological Markers;Biology;Breast Cancer Cell;breast cancer progression;Cancer Biology;cancer cell;cancer stem cell;Cell Proliferation;Cells;Cessation of life;Clinical;Complex;Cytometry;Data;Disease;Distant;Epidermal Growth Factor Receptor;epithelial to mesenchymal transition;Estrogen Receptors;Exhibits;Fibroblasts;follow-up;Genes;Genetic;Goals;high risk;Human;Immune;Immune response;Immune system;Immunocompetent;Immunosuppression;Implant;Incidence;Invaded;Knowledge;Laboratories;loss of function;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Molecular;molecular subtypes;mortality;mouse model;Mus;Myeloid-derived suppressor cells;Neoplasm Metastasis;neoplastic;neoplastic cell;neutrophil;new therapeutic target;novel;novel marker;novel therapeutic intervention;Oncogenic;overexpression;Pathway interactions;Patients;Play;Progesterone Receptors;Prognosis;prognostic;public health relevance;receptor;recruit;Recurrence;refractory cancer;Regulation;Regulatory T-Lymphocyte;Resistance;Role;Signal Pathway;Signal Transduction;T-Lymphocyte;targeted treatment;therapeutic target;trait;Transcriptional Coactivator with PDZ-Binding Motif;Transgenic Mice;Treatment Protocols;triple-negative invasive breast carcinoma;tumor;tumor microenvironment;tumor progression;tumor-immune system interactions;Vascular Endothelial Cell

PROJECT_TITLE: TAZ-driven Regulation of Tumor Microenvironment in Triple-Negative Breast Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-A (O1)]


NIH_SPENDING_CATS: Behavioral and Social Science

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Improving the health of all Americans, especially in the area of chronic diseases such as cardiovascular disease, pulmonary disorders and related conditions, relies on a strong diverse biomedical workforce that is prepared to address these health problems through basic and translational research. Our program trains talented undergraduates from groups underrepresented in biomedical science using a philosophy based on findings from educational scholarship and focused on health issues related to the NHLBI mission. We offer an intensive summer research experience supplemented with workshops in scientific skills, group activities that enhance self-actualization as scientists, career exploration and social events that encourage belonging, thereby preparing our trainees for advanced study in biomedical research.

PI_NAMEs: MAGUIRE, JAMIE LYNN (contact)

PROGRAM_OFFICER_NAME: PHILP, DEBORAH

PROJECT_TERMS: Address;American;anti-racism;Area;Arts;Awareness;Bachelor's Degree;Basic Science;Biomedical Research;Boston;Cardiology;Cardiovascular Diseases;career;Career Exploration;Chronic Disease;Clinical;Clinical Sciences;cohort;Collaborations;college;Communities;Creativeness;Data;Disadvantaged;doctoral student;Education;Educational workshop;Enrollment;Environment;Evaluation;Event;experience;Faculty;Foundations;Funding;Goals;graduate school;graduate student;Grant;Growth;Health;Health Sciences;improved;Individual;insight;Institution;interdisciplinary collaboration;Interdisciplinary Study;interest;junior high school;laboratory experience;Lateral;Leadership;Learning;Left;Literature;Lung Diseases;Medical center;medical schools;Mentors;Mentorship;Mind;minority student;Mission;Modeling;Molecular;Museums;National Heart, Lung, and Blood Institute;novel;novel strategies;outreach;outreach program;Participant;peer coaching;Philosophy;Population Heterogeneity;Positioning Attribute;Postbaccalaureate;Postdoctoral Fellow;professor;programs;Recording of previous events;Research;Research Institute;Research Training;residence;Resources;response;Role;Scholarship;Schools;Science;Scientist;Self Efficacy;skills;social;Stereotyping;student participation;Students;success;summer research;Surveys;Talents;Thinking;Training;Training Programs;Translational Research;Transportation;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities

PROJECT_TITLE: Building Diversity in Biomedical Sciences

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-K (O1)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Lead Poisoning;Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: MIAMI

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

PHR: PROJECT NARRATIVE Learning deficits, poor school performance, and psychopathologies are documented effects of childhood lead exposure. Our proposed studies integrate molecular-cellular, network and circuits, brain volume and connectivity, and cognitive/behavioral approaches to provide a comprehensive understanding of neurobiological mechanisms by which lead exposure results in cognitive function deficits and risk of psychiatric disease. We are also assessing the flavonoid nutraceutical 7,8-dihydroxyflavone as an intervention to improve cognitive and neuropsychological deficits associated with childhood lead exposure.

PI_NAMEs: GUILARTE, TOMAS R (contact)

PROJECT_TERMS: Absence Epilepsy;Adolescence;Adolescent and Young Adult;Affect;Agonist;Animal Model;arm;awake;Behavior;Behavioral;behavioral impairment;behavioral outcome;Blood;blood-brain barrier permeabilization;Brain;Brain region;brain volume;Brain-Derived Neurotrophic Factor;Cell Physiology;Cells;Child;Childhood;Chronic;Cognition;Cognitive;Cognitive deficits;cognitive function;Complement;Consumption;Designer Drugs;designer receptors exclusively activated by designer drugs;Development;Developmental Course;Diet therapy;Diffusion Magnetic Resonance Imaging;effective therapy;effectiveness evaluation;Electrophysiology (science);Equilibrium;Female;Fiber;Flavonoids;Functional disorder;Glutamate Decarboxylase;Health;Hippocampus;Human;Image;imaging study;improved;innovation;Interneurons;Intervention;Knowledge;Lead;lead exposure;lead ion;Learning;Life;Life Cycle Stages;Lifelong disability;Link;Magnetic Resonance Imaging;Major Depressive Disorder;male;Measures;Medial;Mental disorders;mimetics;Molecular;Nervous System Disorder;network dysfunction;neurobiological mechanism;Neurobiology;Neurologic;neuropsychiatric disorder;Neuropsychology;novel;Nutraceutical;optogenetics;Parvalbumins;Pathology;Pathway interactions;Pattern;Performance;Periodicity;persistent symptom;preclinical study;Prefrontal Cortex;prepulse inhibition;Problem behavior;Psychopathology;Public Health;Radial;Rattus;receptor;Research;Risk;Risk Factors;Schizophrenia;Schools;Short-Term Memory;small molecule;Startle Reaction;Synapses;Testing;Time;tractography;translational study;translational therapeutics;Viral;young adult

PROJECT_TITLE: Neurobiology of lead exposure and risk of psychiatric disease


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Modern non-tobacco oral nicotine pouches with pH adjusted to enhance sensory experience and appeal of high- nicotine products may appeal to young people. The proposed project will conduct two double-blinded within- subject randomized clinical trials to examine the effects of nicotine concentration and pH and their interaction effects on behavioral responses such as sensory experience, product appeal, and abuse liability of nicotine pouches in young adult dual users of nicotine pouches and e-cigarettes. The results of the proposed research will be significant because it will complement current research on regulation targets with actionable insights on the modifiable factors related to initiation and use of a novel class of oral nicotine products.

PI_NAMEs: HAN, DAE HEE  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: absorption;abuse liability;Acids;aged;Area;Area Under Curve;base;Behavioral;behavioral response;Blood Circulation;career;career development;Categories;Central Nervous System;Characteristics;Clinical Trials;Complement;Consumption;Data;Dependence;Development Plans;Double-Blind Method;Electronic cigarette;electronic cigarette use;electronic cigarette user;Epidemiology;Equation;experience;experimental study;Fiber;Fruit;Genus Mentha;Health;Hour;Human;improved;Inhalation;innovation;insight;interest;irritation;Laboratory Research;Manufacturer;Marketing;Measures;Mediating;Mediation;Modernization;Nicotine;Nicotine Dependence;nicotine exposure;nicotine use;nicotine user;novel;Oral;Oral cavity;Outcome;Participant;Perception;Persons;Pharmaceutical Preparations;Phase;Plant Leaves;Policies;Population;Prevalence;Property;Protocols documentation;Psychological reinforcement;randomized, clinical trials;Regulation;Reporting;Research;Research Personnel;Risk;Salts;Self Administration;Sensory;sex;skills;Smokeless Tobacco;Sodium Chloride;Symptoms;Taste Perception;Testing;Time;time use;Tobacco;tobacco exposure;tobacco products;tobacco regulatory science;tobacco user;tobacco-free;Toxic effect;Training;Translating;vaping;Variant;Visit;young adult

PROJECT_TITLE: Effect of Product Characteristics on the Abuse Liability of Nicotine Pouches

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-Q (50)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE The interactions between hippocampal and cortical circuits play a critical role in the process of memory formation, and dopamine influences memory processing by signaling the motivational salience of stimuli. The proposed project seeks to characterize the circuit mechanisms underlying the modulation of cortical networks by hippocampal inputs and dopamine across learning. A deeper understanding of hippocampal-cortical interactions and their neuromodulation may provide the foundation for identifying circuit elements that are selectively misregulated in memory disorders, such as Alzheimer's disease.

PI_NAMEs: SIAPAS, ATHANASSIOS  (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Acceleration;Address;Affect;Alzheimer's Disease;Animals;Area;Association Learning;Auditory;Auditory area;auditory stimulus;Automobile Driving;Axon;Behavior;Behavioral;Brain;Calcium;Chemosensitization;Complex;Data;Decision Making;Dopamine;Elements;Episodic memory;Event;Evolution;Excitatory Postsynaptic Potentials;experimental study;extracellular;Fiber;Foundations;Hippocampus;Image;image registration;in vivo;Injections;Learning;Light;Location;Measurement;Measures;Memory;memory consolidation;Memory Disorders;memory encoding;memory process;memory recall;motivated behavior;Motivation;neocortical;neural;Neurons;neuroregulation;optogenetics;Output;Pathway interactions;pharmacologic;Phase;Play;Process;Punishment;Research;response;Rewards;Role;signal processing;Signal Transduction;Site;Sleep;Slow-Wave Sleep;Stimulus;Structure;Synapses;Testing;two-photon;Wakefulness;Whole-Cell Recordings

PROJECT_TITLE: Dopaminergic Modulation of Hippocampal-Cortical Interactions in Learning

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: ALBUQUERQUE

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Project Narrative  We propose to transform our current MD/PhD program into a robust LEAD MSTP through a combination of strongly supportive new leadership in the University of New Mexico Health Sciences Center, increased institutional financial support, and the proposed MSTP support. This Multiple PI/PD proposal will build on strong predoctoral training in the Biomedical Sciences Graduate Program to incorporate training opportunities in Health Equity Sciences, Bioengineering, and Computational Sciences. The University of New Mexico LEAD MSTP will provide a student-centered, integrated training experience that builds on past successes to develop exceptional, diverse clinician scientists who are prepared to address difficult issues in translational research and health equity.

PI_NAMEs: BACA, JUSTIN THOMAS (contact);PERKINS, DAVID LINN

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: diversity and equity;Lead;Medical;New Mexico;Scientist;Training Programs;Universities

PROJECT_TITLE: University of New Mexico Leading Equity and Diversity in the Medical Scientist Training Program (UNM LEAD MSTP)

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: This regional and national research network is relevant to the NIH/ NINDS mission of offering every eligible patient an opportunity to participate in a Stroke Net network trial, to result in improved public health. The short- term benefits of optimizing networks and maximizing efficiencies of stroke clinical trial performance will yield long-term benefits of having more trials across the spectrum of stroke care (prevention, treatment, recovery) completed faster, yielding more treatment opportunities for all. These benefits, coupled with an active career development program, will result in a sustained network with researchers that can further forward a cutting- edge NIH stroke trial portfolio.

PI_NAMEs: MEYER, BRETT C (contact)

PROGRAM_OFFICER_NAME: MCCARTHY, SEAN PATRICK

PROJECT_TERMS: Acute;acute care;Address;Advisory Committees;Area;base;Biological Markers;Brain;burden of illness;Caliber;care delivery;career;career development;Caring;Clinical Trials;Collaborations;Contracts;Country;Coupled;Dedications;Department chair;design;Development;Discipline;Educational process of instructing;Eligibility Determination;Enrollment;Ensure;ethnic diversity;experience;Fellowship;Future;Goals;Health;Health Sciences;Image;improved;Industry;Infrastructure;Institutional Review Boards;investigator training;Knowledge;Leadership;member;Mentors;Mission;National Institute of Neurological Disorders and Stroke;Nerve Regeneration;Nervous System;Nervous System Disorder;Outcome;Participant;Patients;Pediatrics;Performance;Population;Prevention;Procedures;Process;Productivity;Program Development;programs;Public Health;Qualifying;racial diversity;Recording of previous events;Records;Recovery;Rehabilitation therapy;Research;Research Activity;research faculty;Research Personnel;Research Training;Resources;Science;Site;Specialist;Stroke;stroke clinical trials;stroke patient;Stroke prevention;stroke trials;StrokeNet trials;success;Techniques;Time;time interval;tool;Training;Training Programs;trial enrollment;United States National Institutes of Health;Vocational Guidance;working group

PROJECT_TITLE: San Diego StrokeNet+

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-W (17)]


ORG_NAME: J. DAVID GLADSTONE INSTITUTES

PHR: PROJECT NARRATIVE CMV infection is a leading cause of congenital birth defects and both solid-organ and bone-marrow transplant failures and is a major unmet medical need due to resistance to current antiviral therapeutics. This project will lay the foundations for a new class of antivirals that disrupt viral transcriptional feedback circuits, a ubiquitous biological regulatory mechanism utilized by many viruses. This therapeutic strategy could enable new classes of drugs targeting diverse feedback circuits, which are hypothesized to have a high barrier to the evolution of drug resistance.

PI_NAMEs: WEINBERGER, LEOR S (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: Animals;Anti-viral Agents;Anti-viral resistance;Anti-viral Therapy;Apoptosis;Autophagocytosis;Binding;Binding Sites;Biological;Biological Availability;Blindness;Bone Marrow Transplantation;Cell Death;Cells;Cessation of life;Clinical;clinical translation;Congenital Abnormality;cost;Cytomegalovirus;Cytomegalovirus Infections;cytotoxic;Data;deafness;Development;DNA;DNA Binding;DNA-Protein Interaction;Dose;Dose Limiting;Down's Syndrome;Down-Regulation;Drops;Drug Kinetics;Drug resistance;Drug Targeting;druggable target;Evaluation;Evolution;Failure;Feedback;Fetal Alcohol Syndrome;Foundations;Ganciclovir;Gene Library;Genes;Genetic;Genetic Transcription;Genetic Variation;Goals;Herpesviridae;Human;Human Herpesvirus 5;Immediate-Early Genes;Immunocompromised Host;Kinetics;Literature;mathematical model;Mediating;Medical;Mental Retardation;Modeling;Modification;Morbidity - disease rate;mortality;Mus;Mutate;Mutation;mutation screening;Nature;Neutropenia;novel drug class;novel therapeutics;Oral;Organ;Outcome;Pathogenesis;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Population;predictive modeling;Probability;promoter;Proteins;Publications;Randomized;Recombinants;Reporting;resilience;Resistance;resistance mechanism;Rest;Solid;Spinal Dysraphism;standard of care;Testing;Theoretical model;theories;Therapeutic;Toxic effect;translation to humans;Transplantation;Vaccines;Validation;Viral;Viral load measurement;viral resistance;virology;Virus;virus genetics;Virus Replication;Work

PROJECT_TITLE: Targeting Feedback Circuitry for Antiviral Therapy

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Rare Diseases;Vaccine Related

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: Narrative There are sixteen viruses similar to the rabies virus which cause rabies disease but which are genetically different enough that the current rabies virus vaccine is not projective. This grant application proposes to develop a new generation of more broadly efficient vaccines and antibodies, which will protect against rabies disease independent of the virus causing it.

PI_NAMEs: SCHNELL, MATTHIAS JOHANNES (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Address;Animals;Antibodies;antibody-dependent cell cytotoxicity;Antibody-mediated protection;Applications Grants;Biological Assay;Biological Products;Chiroptera;Communicable Diseases;Competitive Binding;Complement;cross reactivity;Data;design;Disease;Disease Outbreaks;Enzyme-Linked Immunosorbent Assay;Epitope Mapping;Escape Mutant;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;Funding;Generations;Glycoproteins;Goals;Harvest;Human;Hybridomas;Immune response;Immunity;Immunize;immunogenicity;in vivo;Infection;Intervention;Knowledge;Lyssavirus;Mediating;Modeling;Mokola virus;Monoclonal Antibodies;Mus;Mutation;Natural Killer Cells;neutralizing antibody;neutralizing monoclonal antibodies;novel;Pathway interactions;Persons;Phagocytosis;Property;Rabies;Rabies virus;receptor binding;Recombinants;response;seroconversion;Serum;Spleen;Suggestion;Testing;Therapeutic;Transgenic Mice;Vaccinated;Vaccines;Viral;Virus;Visit

PROJECT_TITLE: Pan-lyssavirus therapeutics and mechanisms of protection against lyssaviruses

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-C(02)]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Hematology;Infectious Diseases;Neurosciences;Rare Diseases;Sepsis

ORG_CITY: BALTIMORE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: NARRATIVE: Sepsis is a life-threatening condition caused by body’s overwhelming response to infection. For patients who survive sepsis, more than 50% develop neurocognitive dysfunction and memory loss. The goal of the proposed study is to examine the role of brain inflammation in neurocognitive dysfunction in sepsis and to identify potential therapeutic targets.

PI_NAMEs: CHAO, WEI  (contact);WU, JUNFANG ;ZOU, LIN

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Address;Affect;affective disturbance;Animals;antagonist;Astrocytes;Attenuated;Blood - brain barrier anatomy;Blood Circulation;blood-brain barrier permeabilization;Brain;brain cell;Cells;Cerebrum;Chronic;Circulation;Clinical;Coma;cytokine;Data;Delirium;Encephalitis;Encephalopathies;Endosomes;Exhibits;exosome;extracellular;Functional disorder;functional improvement;glial activation;Goals;Guanosine;Heart;Human;Immune;immune activation;Immune response;Impaired cognition;Impairment;improved;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Innate Immune Response;insight;intercellular communication;Intestines;Lead;Life;Literature;locked nucleic acid;loss of function;Mediating;Mediator;Memory Loss;Microglia;MicroRNAs;Modeling;Molecular;mortality;mouse model;Mus;Nerve Degeneration;Nervous System Physiology;Neurocognitive;neuroinflammation;new therapeutic target;Organ;Outcome;pathogen;Pathogenesis;Pathway interactions;Patients;Pattern;Perforation;Peripheral;Pilot Projects;Plasma;pre-clinical;Production;Psyche structure;Publishing;Reporting;response;RNA;Rodent;Role;Sepsis;septic;septic patients;Severities;Signal Pathway;Signal Transduction;Spleen;Survivors;Testing;Therapeutic;therapeutic target;TLR7 gene;Treatment Efficacy;Uridine;vector

PROJECT_TITLE: Targeting brain inflammation and neurocognitive dysfunction in sepsis

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Biotechnology;Genetics;Osteoporosis

ORG_CITY: New York

ORG_NAME: HOSPITAL FOR SPECIAL SURGERY

PHR: Project Narrative Bone destruction is a severe consequence of many skeletal diseases, such as osteoporosis and rheumatoid arthritis. This application will explore underlying mechanisms and provide new attractive therapeutic approaches for suppressing bone destruction and preventing disease development and progress.

PI_NAMEs: ZHAO, BAOHONG  (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Adult;Albers-Schonberg disease;Animal Model;beta catenin;Biology;Biomechanics;bone;bone cell;Bone Diseases;bone mass;Bone remodeling;bone repair;Bone Resorption;Cardiovascular Diseases;Categories;Cell Differentiation process;Cell Physiology;cell type;Cells;Complex;conditional knockout;Coupling;Development;Disease;Epigenetic Process;epigenetic regulation;Equilibrium;Exhibits;Future;Gene Expression Regulation;Genes;genetic approach;Genetic Diseases;Genetic Transcription;Genomics;Goals;Homeostasis;human disease;In Vitro;in vivo;Innate Bone Remodeling;insight;Knock-out;Knockout Mice;Life;MALAT1 gene;Malignant Neoplasms;Mediating;Mesenchymal Stem Cells;Molecular;mRNA Precursor;Mus;novel;novel diagnostics;novel therapeutic intervention;novel therapeutics;Nuclear;osteoblast differentiation;Osteoblasts;osteoclastogenesis;Osteoclasts;Osteocytes;Osteogenesis;osteogenic;Osteoporosis;osteoporotic bone;Osteosclerosis;Pathologic;Pathway interactions;Phenotype;Physiologic Ossification;prevent;Process;reconstitution;Regulation;Reporting;Rheumatoid Arthritis;RNA Splicing;scaffold;Signal Transduction;skeletal;skeletal disorder;Skeleton;Techniques;Testing;Therapeutic;Time;Transcript;Transcriptional Regulation;transcriptome sequencing;Transgenic Mice;Treatment Efficacy;Untranslated RNA

PROJECT_TITLE: Regulation of bone homeostasis and remodeling by long noncoding RNA Malat1

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: DAYTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: WRIGHT STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative A major question in photobiology is how ultraviolet B radiation (UVB)-treated skin sends systemic signals. This project applies multiple well-established techniques and approaches at clinical, cellular and molecular levels to investigate the involvement of the lipid mediator Platelet-activating factor in UVB-induced microvesicle particle release which could be the transmitter for systemic signaling effects. These studies have significant therapeutic implications and will provide novel insights and targets into processes from photosensitivity disorders to medical phototherapy.

PI_NAMEs: KEMP, MICHAEL GEORGE;TRAVERS, JEFFREY B. (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: acid sphingomyelinase;Acute;Address;Agonist;Antioxidants;Binding;Biochemical Reaction;Cell Line;Cells;Clinical;Complement Factor B;cytokine;Cytoplasm;design;Disease;Dose;environmental stressor;Enzyme Inhibition;Enzymes;Epidermis;Epithelial Cells;Exhibits;Fever;Generations;Genetic;genetic approach;Goals;Human;human subject;Imipramine;Immunosuppression;In Vitro;in vivo;Individual;Inflammation;Inflammatory;Inflammatory Response;inhibitor;insight;Ionizing radiation;keratinocyte;Knock-out;Knockout Mice;Knowledge;Laboratories;Link;lipid mediator;Lipids;Lupus;mast cell;Measures;Mediating;Medical;Membrane;Metabolic;microvesicles;Modeling;Molecular;mouse model;Mus;novel;novel strategies;novel therapeutics;Nuclear;Null Lymphocytes;Oral;particle;Pathologic;Pathway interactions;Penetration;pharmacologic;Pharmacology;Photobiology;Photosensitivity;Photosensitivity Disorders;Phototherapy;Phototoxic Dermatitis;Platelet Activating Factor;platelet activating factor receptor;Process;Production;Proteins;PUVA Photochemotherapy;Radiation;Radiation exposure;radiation response;Reaction;Reactive Oxygen Species;Receptor Signaling;Regulatory T-Lymphocyte;response;Role;Signal Transduction;Signal Transduction Pathway;Skin;Stimulus;stressor;Techniques;Testing;Therapeutic;tool;Travel;Ultraviolet B Radiation;UVB induced;Vesicle;Vitamin D;XPA gene

PROJECT_TITLE: UVB radiation-generated microvesicle particles as effectors for photosensitivity

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Immunotherapy;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE We have had success in treating patients with hematological malignancies by using their own immune cells modified with a chimeric molecule that eliminates tumor cells but spare part of the immune B-lymphocytes. We are now extending this approach to solid tumors such as ovarian cancer that remains a tumor with poor prognosis. In this project we intend test in a Phase I clinical trial the safety, persistence and in vivo functionality of these cells that have been modified to persist target an antigen expressed by ovarian cancer cells.

PI_NAMEs: DOTTI, GIANPIETRO  (contact);VAN LE, LINDA

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Adoptive Immunotherapy;Aftercare;angiogenesis;Antigen Targeting;Antigens;Apoptotic;Ascites;Autologous;B lymphoid malignancy;B-Lymphocytes;base;Binding;Biological Availability;Biopsy;cancer cell;Cancer Model;CD19 Antigens;CD19 gene;CD276 gene;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;clinical application;clinical development;Clinical Research;Complex;Cross Reactions;cross reactivity;Cyclophosphamide;Data;Development;Dose;effector T cell;Electroporation;exosome;Family;fludarabine;FOLR1 gene;Goals;Greater sac of peritoneum;Growth;Hand;Hematologic Neoplasms;Human;Immune;immune cell infiltrate;immune checkpoint blockade;Immunocompetent;Immunologic Monitoring;Immunologics;Immunotherapy;in vivo;Infusion procedures;inhibitor;innate immune function;Integral Membrane Protein;intraperitoneal;leukemia;Link;Macrophage;Malignant Breast Neoplasm;Malignant lymphoid neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;manufacture;Melanoma;Messenger RNA;Modeling;Modification;Monitor;Monoclonal Antibodies;mouse model;Mus;Myeloid-derived suppressor cells;neoplastic cell;Normal tissue morphology;North Carolina;novel;Oral;Organ;pancreatic cancer model;participant enrollment;Patients;PD-1 blockade;peripheral blood;Peritoneal Fluid;Phase;Phase I Clinical Trials;Positioning Attribute;pre-clinical;preclinical study;prevent;Procedures;Prognosis;programs;Publishing;Reagent;receptor;Receptor Protein-Tyrosine Kinases;Recurrence;Refractory;Regulatory T-Lymphocyte;Relapse;Reporting;response;Safety;safety assessment;Sampling;Serine;Shapes;Signal Transduction;small molecule inhibitor;Solid Neoplasm;Specificity;success;T cell therapy;Testing;Therapeutic;Tissues;Toxic effect;tumor;Tumor Escape;tumor heterogeneity;tumor microenvironment;Tumor Promotion;Tumor-associated macrophages;tumor-immune system interactions;tumorigenesis;tumorigenic;Universities;Woman;Xenograft procedure

PROJECT_TITLE: Targeting B7-H3 in ovarian cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: OAKVILLE

ORG_NAME: NATIONAL EGG REGULATORY OFFICIALS, INC.

ORG_STATE: WA

PHR: National Egg Regulatory Officials Annual Conference & Training Seminar  Project Narrative Grant funds assistance will be used to develop and conduct a three-day conference and training seminar that will provide a forum for stakeholders to share information and promote integration through collaboration. Grant funds will also assist state members that do not have travel funding to attend the Annual Conference & Training Seminar.

PI_NAMEs: BOYD, MICHELLE L. (contact);SCHWAB, SARAH MARIE

PROGRAM_OFFICER_NAME: WEBB, SUZANNE

PROJECT_TITLE: NERO Annual Conference & Training Seminar 2021 - 2025


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Eye Disease and Disorders of Vision;Immunization;Immunotherapy;Infectious Diseases;Prevention;Rheumatoid Arthritis;Scleroderma;Vaccine Related

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: The current SARS-CoV-2 pandemic has had devastating consequences, with more than 110,000,000 cases and 2,400,000 deaths worldwide. Although we have made remarkable strides developing and delivering vaccines designed to protect against SARS-CoV-2 infection, there are a number of unanswered questions regarding efficacy and potential side effects of vaccination in understudied patient populations with underlying autoimmune disease. In this proposal, we will use novel methods of autoantibody detection and a combination of patient reported outcome measures (PROs)/physician assessments in a prospective cohort of rheumatic disease patients undergoing SARS-CoV-2 vaccination to evaluate the relationship between anti-viral immune responses, formation of self-reactive antibodies, change in disease activity, and development of new autoimmune clinical manifestations.

PI_NAMEs: ASCHERMAN, DANA P;DOMSIC, ROBYN THERESE (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: 2019-nCoV;adaptive immune response;Address;anti-tumor immune response;Anti-viral Response;Antibodies;Antigens;Autoantibodies;Autoimmune;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;autoinflammatory;autoreactivity;biobank;biomarker development;Cessation of life;Clinical;cohort;Coupled;COVID-19 pandemic;COVID-19 sequelae;COVID-19 vaccination;COVID-19 vaccine;cross reactivity;cytokine release syndrome;Data;data integration;Data Management Resources;Database Management Systems;Databases;design;Detection;Development;digital assessment;digital platform;Disease;Disease susceptibility;disorder risk;experience;Feedback;gel electrophoresis;Generations;Idiopathic Inflammatory Myopathies;Immune;immune activation;Immune response;Immune system;Immunization Programs;Immunologics;Immunoprecipitation;Infection;Infrastructure;Innate Immune Response;insight;Knowledge;Link;Literature;Longitudinal cohort;Measures;Methods;Modeling;Molecular Mimicry;Morbidity - disease rate;mortality;novel;Observational Study;Online Systems;Organ;Outcome Measure;Patient Outcomes Assessments;patient population;Patients;Peptides;Pharmaceutical Preparations;Physicians;Population Control;Positioning Attribute;Price;Prospective cohort;Proteins;Questionnaires;radiotracer;Resources;response;Rheumatism;Rheumatoid Arthritis;Risk;Sampling;SARS-CoV-2 infection;SARS-CoV-2 spike protein;Sequence Homology;Serology;Serum;side effect;Sjogren's Syndrome;Specimen;Statistical Models;stem;System;Systemic Scleroderma;Techniques;Technology;Testing;Therapeutic immunosuppression;Time;Tissues;Universities;Vaccinated;Vaccination;vaccine delivery;Vaccine Design;vaccine development;vaccine efficacy;vaccine immunogenicity;vaccine response;vaccine trial;Vaccines;Viral;Viral Proteins;Viral Vaccines;Work

PROJECT_TITLE: Evaluating Clinical and Immunological Consequences of SARS-CoV-2 Vaccination in Rheumatic Disease

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]


NIH_SPENDING_CATS: Kidney Disease;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: Project Summary/Abstract Activation of αvβ3 integrin on podocytes is thought to be an early pathological process in the development of kidney disease, especially FSGS and DN. Based on the newly discovered renoprotective role of ICOSL in early kidney disease, we aim to define the precise mechanistic action of ICOSL and its therapeutic potential in this proposal. The successful completion of our proposed study will provide novel and safe avenues for the treatment of glomerular disease, where αvβ3 integrin activation is involved.

PI_NAMEs: HAHM, EUNSIL  (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Acute;Animal Model;Animals;antagonist;Anti-Hypertensive Agents;Behavior;Binding;cell type;Cells;Cilengitide;Clinical;Clinical Treatment;Clinical Trials;Complex;Data;Defense Mechanisms;design;Development;Diabetic Nephropathy;Disease;Disease Progression;Drug Kinetics;Endothelial Cells;Event;Focal and Segmental Glomerulosclerosis;Foot Process;Glioblastoma;glomerular endothelium;Half-Life;Hour;Human;Immunologics;improved;In Vitro;in vivo;inducible gene expression;Injections;Injury;Injury to Kidney;Integrin alphaVbeta3;Integrin Binding;Integrins;Interleukin-2;Kidney;Kidney Diseases;Kidney Failure;Kinetics;knockout animal;Knockout Mice;Ligands;Link;Measures;Mechanical Stress;Mediating;mesangial cell;Molecular;Morphology;nephrogenesis;novel;novel therapeutics;Oxidative Stress;Pathogenesis;Pathologic;Pathologic Processes;Pathway interactions;Physiological;podocyte;Predisposition;Proteinuria;Publishing;receptor;Recombinants;Regulation;Renal function;Renal glomerular disease;response;RGD (sequence);Role;Signal Transduction;Specificity;success;T-Cell Activation;targeted treatment;Testing;Therapeutic;therapeutic evaluation;Time;Tissues;Wild Type Mouse;Work

PROJECT_TITLE: The role of ICOSL in renal protection

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]