ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Substance Misuse;Therapeutic Cannabinoid Research

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: BROWN UNIVERSITY

PHR: PROJECT NARRATIVE Cannabis is the most commonly used psychoactive substance among those with Alcohol Use Disorder (AUD), yet there is a lack of data examining the direct impact of cannabis use on alcohol-related treatment outcomes. This project will use ecological momentary assessment and transdermal alcohol biosensors to study the momentary impact of cannabis use on alcohol craving and consumption in the natural environment among those early in AUD treatment. Results from this research will have direct impact on cannabis messaging, clinical decision-making, and intervention development for those with AUD.

PI_NAMEs: GUNN, RACHEL LYN (contact)

PROGRAM_OFFICER_NAME: FALK, DANIEL EVAN

PROJECT_TERMS: Acute;addiction;Address;Aftercare;alcohol abstinence;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol craving;alcohol demand;alcohol effect;alcohol measurement;alcohol use disorder;Alcohols;Biosensor;burden of illness;Cannabis;cannabis use behavior;Characteristics;clinical decision-making;clinical development;Complement;Consumption;craving;Data;design;Development;Disease remission;drinking;Ecological momentary assessment;Environment;Event;Frequencies;Future;Goals;Grain;Heavy Drinking;Impulsivity;Individual;Individual Differences;Knowledge;Laboratories;Light;Literature;longitudinal dataset;longitudinal design;marijuana legalization;marijuana use;marijuana user;Measures;Mediating;Methods;Outcome;Participant;Patient Self-Report;Patients;Pattern;persistent symptom;Persons;Phase;Policies;Predisposition;prospective;Provider;Psychotropic Drugs;Recording of previous events;Relapse;Research;Risk;Risk Factors;Sampling;Technology;Tetrahydrocannabinol;theories;therapy development;Time;trait impulsivity;Treatment outcome;United States National Institutes of Health;Work;young adult

PROJECT_TITLE: Effect of Cannabis Use on Alcohol Craving and Consumption among those in Alcohol Treatment

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BROWNING

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ADMINISTRATION

ORG_FIPS: US

ORG_NAME: BLACKFEET COMMUNITY COLLEGE

ORG_STATE: MT

PHR: This project will develop the ability of Blackfeet people to improve their own mental health. This will be accomplished by developing the Blackfeet Community College Center for Culture as Medicine. The center’s research focuses on interventions utilizing traditional Blackfeet ways to improve mental health of the community.

PI_NAMEs: MATTHEWS, BETTY  (contact)

PROGRAM_OFFICER_NAME: RICHARDS, CRYSTAL LYNETTE

PROJECT_TERMS: Address;Affect;Belief;Biomedical Research;Blackfeet;career;Cause of Death;Charge;college;Communities;community college;Community Health;Death Rate;Development;Disease;Education;Educational workshop;experience;Faculty;faculty research;Funding;Future;Future Generations;Goals;Grant;Health;health disparity;Health equity research;improved;Indian reservation;Individual;interest;Intervention;Investments;Laboratory Research;Language;Light;Medicine;member;Mental Health;Mission;Montana;Native American community;Native American Research Center for Health;Native Americans;non-Native;Participant;Persons;physical conditioning;Pilot Projects;public education;remediation;Research;research and development;research in practice;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Reservations;Science;Source;student training;Students;Training;tribal college;Tribes;Universities;university student

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-Y(55)]


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Complementary and Integrative Health;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PHR: The BCC-Center for Culture as Medicine Administrative Core will facilitate the accomplishment of the center’s specific aims as well as the aims of the center’s projects. Importantly, the Administrative Core will maintain the relationships with the Blackfeet Community and strive to develop a sustainable research center that will positively affect the mental health of the Blackfeet Nation.

PI_NAMEs: BIRD, KARLA  (contact)

PROJECT_TERMS: Address;Advisory Committees;Affect;Biomedical Research;Blackfeet;Collaborations;Communication;Communities;community advisory board;community college;Data;Developing Countries;Development;Evaluation;Event;Faculty;faculty research;Funding;Future;Goals;Grant;Health;Health Disparities Research;Health equity research;Human Resources;improved;Individual;Information Dissemination;interest;Intervention;Medicine;meetings;member;Mental Health;Mentors;Monitor;Native American Research Center for Health;Newsletter;Participant;Persons;physical conditioning;Positioning Attribute;programs;Publishing;Recommendation;recruit;Research;research and development;Research Personnel;Research Project Grants;Reservations;Resources;Scientist;student training;Students;success;web site;Work

PROJECT_TITLE: Blackfeet Community College Center for Culture as Medicine, Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-Y]


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: HANOVER

ORG_DEPT: BIOLOGY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE Acute and chronic bacterial infections often entail microbial biofilm growth, rendering pathogens difficult or impossible to remove with out surgical resection. My lab studies how cell-cell and cell-surface interaction lead to higher order biofilm architecture, composition, and community dynamics. Here we propose to study how predatory viruses and bacteria propagate among prey bacteria inside biofilms, which can inform how novel alternative antimicrobial strategies could be used against biofilms where traditional antibiotics fail.

PI_NAMEs: NADELL, CAREY  (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Acute;acute infection;Affect;Antibiotics;antimicrobial;Architecture;Attention;Bacteria;bacterial fitness;Bacterial Genome;Bacterial Infections;Bacteriophages;Bdellovibrio;Binding;Biological Models;Cell Communication;Cell surface;Cells;Chitin;Cholera;Chronic;chronic infection;Clinical;Communities;Complex;Consumption;Environment;Escherichia coli;Excision;fighting;frontier;Genome;Glass;Growth;host microbiota;human disease;Image;Infection;insight;Lead;life history;Liquid substance;Lytic;marine;Mechanics;Microbial Biofilms;Nature;novel;novel strategies;Nutrient;Operative Surgical Procedures;particle;pathogen;Pathogenesis;polymicrobial biofilm;Predisposition;Research;Resolution;Role;Shrimp;Structure;Surface;System;Testing;Vibrio;Vibrio cholerae;Vibrio parahaemolyticus;Viral;Virulence;Virus;Work

PROJECT_TITLE: Bacterial and Viral Predator-Prey Dynamics within Bacterial Biofilms at Cellular Resolution

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-J(55)R]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research

ORG_CITY: ALBUQUERQUE

ORG_NAME: NEW MEXICO START-UP FACTORY II, LLC

ORG_STATE: NM

PHR: Project Narrative Translating bench science to the patient and the public faces many challenges, particularly in IDeA states. The objective of this proposal is to develop an educational product to promote and develop biomedical entrepreneurship in the Western IDeA states, addressing the specific needs of both IDeA state academic institutions in developing and strengthening technology transfer programs that stimulate technological innovation, as well as the needs of IDeA state university investigators and innovators (from students to faculty) in translating scientific discoveries and technologies from research laboratories into commercial products that improve human health and promote economic growth in IDeA states. The product of this initiative will constitute a comprehensive, sustainable educational, mentoring and consulting product to accelerate biomedical entrepreneurship and create the next generation of entrepreneurs.

PI_NAMEs: CHAVEZ, JOHN  (contact);DELCAMPO, ROBERT GREGORY;PROSSNITZ, ERIC R

PROGRAM_OFFICER_NAME: ZHOU, YANG

PROJECT_TERMS: Acceleration;Address;Advisory Committees;Affect;Alaska;Area;Award;Awareness;Basic Science;Businesses;Capital;Case Study;Collaborations;commercialization;Databases;design;Development;Development Plans;Economics;Education;education planning;Entrepreneurship;Environment;Evaluation;Exposure to;Face;Faculty;Fees;Funding;Funding Opportunities;Goals;graduate student;Grant;Growth;Hawaii;Health;Healthcare;Human;Idaho;improved;Infrastructure;innovation;Institution;interest;invention;Investments;Knowledge;Laboratory Research;Leadership;Learning;Legal patent;Licensing;Manuals;Marketing;meetings;member;Mentors;Monitor;Montana;Needs Assessment;Nevada;New Mexico;next generation;Occupational activity of managing finances;operation;outreach;Participant;Patients;Phase;Pilot Projects;Postdoctoral Fellow;Process;product development;Program Development;programs;prototype;Research;research and development;Research Personnel;Resources;Science;Scientist;Services;skills;Small Business Innovation Research Grant;Small Business Technology Transfer Research;Structure;Students;success;technological innovation;Technology;technology development;Technology Transfer;Testing;Training;Translating;Translational Research;undergraduate student;Universities;Validation;Visit;Wyoming

PROJECT_TITLE: Development of an Educational Product for Accelerating Solutions for Commercialization and Entrepreneurial Development (ASCEND) in Western IDeA States


PHR: This project will develop the sustainability of the Blackfeet Community College-Center for Culture as Medicine. This will be accomplished by building the scientific expertise needed for a productive center by encouraging BCC students to pursue research careers and return to BCC and developing research capacity within existing and new faculty.

PI_NAMEs: HOYT, DEE  (contact)

PROJECT_TERMS: Address;Alaskan;American Indians;Applications Grants;Appointment;Biological Markers;Biomedical Research;Blackfeet;career;career development;Clinical Research;Collaborations;college;Communities;community college;Data;design;Development;Disease;Disparity;Educational workshop;empowerment;Ethics;experience;Exposure to;Faculty;faculty research;Funding;Goals;Grant;Health;health disparity;health equity;health literacy;Health Status;Human Resources;human study;improved;Incidence;Individual;Infrastructure;interest;Internships;Intervention;laboratory experience;Laboratory Research;Lead;Medicine;meetings;member;Mental Health;Montana;Native American Research Center for Health;Native-Born;Participant;Phase;physical conditioning;Population;Positioning Attribute;Productivity;professor;Program Research Project Grants;programs;Publications;Qualifying;Reduce health disparities;Research;research and development;Research Methodology;Research Personnel;Research Project Grants;Research Support;Rural health equity;Schools;Science;Series;Students;success;summer internship;summer program;Surveys;translational research program;tribal college;undergraduate student;Universities;Work;Writing

PROJECT_TITLE: BCC-CCM Student and Faculty Career Development Project


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Kidney Disease;Machine Learning and Artificial Intelligence;Pediatric;Prevention

ORG_CITY: KANSAS CITY

ORG_NAME: CHILDREN'S MERCY HOSP (KANSAS CITY, MO)

ORG_STATE: MO

PHR: PROJECT NARRATIVE Children with chronic kidney disease (CKD) pose unique challenges to the health care system, which must address not only the primary kidney disorder, but the many extrarenal manifestations which include social function and emotional wellbeing, risk for cardiovascular disease and metabolic bone disease and a high mortality rate in young adulthood. The CKiD study is a landmark cohort study of children with CKD, having rallied more than 50 pediatric nephrology centers across the US and Canada to recruit and study 1100 children with mild to moderate CKD. From 2023 to 2028, the Clinical Coordinating Centers will continue to coordinate study visits with the following long term goals: enhance the current cohort to collect additional data as the new and existing cohorts become young adults; define how risk factors for GFR decline, and early cardiovascular abnormalities detected during childhood ultimately impact long-term health outcomes after transition to adulthood; examine the impact of risks developed during childhood CKD on outcomes in adulthood by linking CKiD data with external sources; and assess the social functioning and emotional well-being of children with CKD to understand their impact on subsequent clinical care and life course.

PI_NAMEs: WARADY, BRADLEY ALAN (contact)

PROGRAM_OFFICER_NAME: GIPSON, DEBBIE SUE

PROJECT_TERMS: 17 year old;Acceleration;Achievement;Acute Renal Failure with Renal Papillary Necrosis;Address;Adolescence;Adolescent;Adolescent and Young Adult;Adult;Affect;African American;Age;Ancillary Study;Behavioral;biobank;Biological Markers;Birth;Blood Pressure;Blood Vessels;bone health;calcification;Canada;Cardiac;Cardiovascular Abnormalities;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Caring;Cellular Phone;Child;Child Welfare;Childhood;Chronic Kidney Failure;Chronic Phase;Clinical;clinical care;clinical center;Clinical Markers;clinical phenotype;Clinical Research;cohort;Cohort Studies;Collaborations;Communities;Computers;Contractor;coronary artery calcium;Data;Data Collection;Death Rate;design;Development;Diagnosis;Dialysis procedure;Disease;disease diagnosis;Disease Outcome;Disease Progression;DNA;Education;electronic data capture system;Electronic Health Record;Eligibility Determination;Emotional;Enrollment;Ensure;Equation;ethnic diversity;Evaluation;Event;Family;follow-up;functional decline;Functional disorder;Genetic study;Glomerular Filtration Rate;Goals;Health;Healthcare Systems;Heart Atrium;High Prevalence;Home;Home Blood Pressure Monitoring;hypertension treatment;improved;indexing;Individual;Information Systems;International;Joints;Kidney;Kidney Diseases;Kidney Transplantation;Laboratories;Leadership;Left;Life Cycle Stages;Link;Machine Learning;machine learning prediction;male;Measurement;Measures;Metabolic;Metabolic Bone Diseases;Metabolic Marker;Methodology;Methods;Midwestern United States;Monitor;Myocardial;Myocardium;Natural History;Nephrology;Neurocognitive;North America;novel;Online Systems;Organ;Outcome;Participant;Patient Recruitments;patient retention;Performance;Persons;Plasma;Population;Predictive Value;Principal Investigator;Process;Puberty;Publications;Quality of life;racial diversity;Readiness;recruit;Relaxation;Renal function;Renal Replacement Therapy;Reporting;Research;Research Personnel;Research Priority;Resources;Risk;Risk Assessment;Risk Factors;Role;Serum;Severities;Site;social determinants;Social Functioning;Source;Standardization;Statistical Methods;Structure;Symptoms;time interval;Training;transition to adulthood;Urine;validation studies;Ventricular;virtual;Visit;Well in self;Writing;young adult;Youth

PROJECT_TITLE: Chronic Kidney Disease in Children (CKiD V)


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Opioid use disorder, a physical and psychological reliance on opioids, kills more than 60,000 Americans each year and has cost the United States healthcare system more than $30 billion. Continuous treatment with pharmacotherapy for the duration of physical and psychological reliance is crucial to optimal outcomes of opioid use disorder but faces barriers with co-occurring substance use disorders. Findings from this study will support the development of health information technology that can help overcome these barriers by routinely incorporating patient needs in clinical decision making.

PI_NAMEs: REESE, THOMAS J (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Patient-centered decision making to improve opioid use disorder treatment

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease

ORG_CITY: WALTHAM

ORG_NAME: THERMEDICAL, INC.

ORG_STATE: MA

PHR: Thermedical is developing the Durablate® Catheter which will deliver Saline Enhanced RF (SERF) ablation to treat Ventricular Tachycardia (VT), a condition that in the United States kills more than half of the 450,000 people who die from Sudden Cardiac Death each year. Currently, VT is treated with Implantable Cardioverter Defibrillators (ICDs), expensive devices that halt VT by delivering shocks to the patient. These shocks can be painful, and recent studies indicate that they also contribute to a shortened life expectancy. A recent first in human clinical trial showed that the Durablate can eliminate or substantially reduce the number of shocks that refractory patients are receiving from their ICDs. Thermedical’s ablation technology will improve the quality of life for patients who have VT and possibly extending their life. Long-term the Durablate Catheter may be used for primary prevention of VT which will greatly reduce the cost of VT treatment and improve the lives of patients suffering from VT.

PI_NAMEs: CURLEY, MICHAEL G (contact)

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: 3-Dimensional;Ablation;Acute;Affect;Agreement;Aneurysm;Anti-Arrhythmia Agents;arm;Arrhythmia;Award;biomaterial compatibility;Breakthrough device;Cardiac;Cardiac Volume;Cardiovascular system;care costs;Catheters;Cessation of life;Characteristics;Chronic;Circulation;Clinical;Clinical Research;Clinical Trials;Communities;Convection;cost;curative treatments;Defibrillators;Development;Devices;Dimensions;editorial;effusion;Electrophysiology (science);Eligibility Determination;Etiology;Event;experience;FDA approved;first-in-human;Funding;Goals;Guidelines;Healthcare Systems;Heart Atrium;human study;Image;Implant;Implantable Defibrillators;implantation;improved;Incidence;Infarction;Ischemia;Lesion;Life;Life Expectancy;Liver neoplasms;Location;Magnetic Resonance Imaging;Maps;Mechanics;Medicare;Medicare/Medicaid;Methods;Modernization;Monitor;Myocardium;Pain;patient population;Patients;Perforation;Persons;Pharmaceutical Preparations;Physicians;prevent;Primary Prevention;Procedures;Publishing;Quality of life;Radiofrequency Interstitial Ablation;reconstruction;Recurrence;Refractory;research clinical testing;response;Safety;safety testing;Saline;Shock;Small Business Innovation Research Grant;standard of care;Sterility;Stroke;structural heart disease;success;sudden cardiac death;Supraventricular tachycardia;Surface;symposium;System;Tachycardia;Techniques;Technology;Thermal Ablation Therapy;Thermal Conductivity;Tissues;tool;United States;United States National Institutes of Health;Validation;Ventricular;Ventricular Arrhythmia;Ventricular Tachycardia

PROJECT_TITLE: Eliminating Ventricular Tachycardia: Pivotal Clinical Trial using the Durablate® Catheter

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-W(12)B]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Nutrition;Precision Medicine;Prevention

ORG_CITY: SAINT LOUIS

ORG_DEPT: CHEMISTRY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative We propose to establish the Washington University Omics Production Center (WU-omics PC) as part of the Multi-Omics for Health and Disease Consortium. The WU-omics PC will profile human genes, proteins, and metabolites by using six different omics profiling technologies. The integration of these omics datasets and others will improve our understanding of human health and potentially lead to new strategies for the early detection, prevention, and treatment of disease in ancestrally diverse populations.

PI_NAMEs: PATTI, GARY J (contact);WANG, TING

PROGRAM_OFFICER_NAME: FUFA, TEMESGEN D

PROJECT_TERMS: Agreement;ATAC-seq;Atlases;Award;Benchmarking;Biochemistry;Biological Assay;bisulfite sequencing;Chemical Exposure;Collection;Communities;Complex;Computer software;computerized data processing;Data;data harmonization;data integration;Data Set;design;Diet;Disease;Early Diagnosis;Ensure;Environmental Exposure;Environmental Health;epigenome;Etiology;experience;flexibility;Genes;Genetic;Genome;genome sequencing;Genomics;Goals;Health;Human;human disease;human pangenome;improved;Infrastructure;innovation;instrumentation;ion mobility;Leadership;Lipids;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;member;metabolomics;Methods;Modeling;Molecular;Molecular Profiling;multidimensional data;multidisciplinary;Multiomic Data;multiple omics;Nomenclature;nutrition;Obesity;Participant;pathogen;Pathogenesis;Phenotype;phenotypic data;Physical activity;pollutant;Population Heterogeneity;Positioning Attribute;precision medicine;Prevention;Procedures;Process;Production;Proteins;Proteomics;Protocols documentation;quality assurance;Quality Control;recruit;Research;Research Personnel;Resources;Sampling;Shipping;Signal Transduction;Site;social determinants;Techniques;Technology;tool;Toxin;transcriptome sequencing;transcriptomics;tumor;United States National Institutes of Health;Universities;Washington;Water;whole genome;Work;working group


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer;Digestive Diseases;Liver Disease;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: STONY BROOK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: Project Narrative While non-proliferating disseminated cancer cells in distant tissues have been observed in many types of cancer, mechanisms of how metastases originate from these dormant cancer cells are unclear. In this proposal we plan to (1) interrogate how dormant cancer cells initiate proliferation and how immune cells regulate these dissemi- nated cancer cells in development to metastases upon stimuli, such as glucocorticoids treatment, and (2) deter- mine immune-stromal cell interactions, and how they orchestrate to regulate cancer dormancy as we age.

PI_NAMEs: HAN, XIAO  (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Address;Adjuvant;Adjuvant Therapy;Adult;Age;aged;Aging;Anxiety;Behavior;Binding;cancer cell;cancer therapy;cancer type;Cause of Death;CDK4 gene;Cell Communication;Cell Cycle Arrest;Cell Cycle Progression;Cell Proliferation;Cells;Chromatin;Clinical;clinically relevant;Data;Development;Disease-Free Survival;Disseminated Malignant Neoplasm;Distant;Elderly;Enzymes;experience;extracellular;Extracellular Matrix;Extracellular Matrix Proteins;Fibroblasts;Frequencies;Glucocorticoid Receptor;Glucocorticoids;Goals;Growth;Hormones;Image;Immune;immune clearance;Immune response;Immune system;Immunization;Immunize;Immunohistochemistry;Immunologic Surveillance;immunoregulation;improved;In Vitro;Injections;interest;Internet;Knowledge;Lead;Literature;Liver;Liver neoplasms;Malignant Neoplasms;Metastatic Neoplasm to the Liver;Modeling;mouse model;Mus;Natural Killer Cells;Neoplasm Metastasis;neutrophil;novel;old mice;Operative Surgical Procedures;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Patients;Phase;Postdoctoral Fellow;prevent;Primary Neoplasm;Proliferating;Protocols documentation;Relapse;Research;Research Personnel;Resected;Risk Factors;Role;Signal Induction;Signal Transduction;Site;Source;Stimulus;Stress;Stromal Cells;T-Cell Depletion;T-Lymphocyte;targeted treatment;Therapeutic;therapy design;Tissues;transcriptomics;tumor;tumor growth;tumor microenvironment;tumor-immune system interactions

PROJECT_TITLE: Immune Regulation of Dormancy at the Metastatic Site


NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Human Genome;Lung;Pediatric;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Asthma is the most common chronic disease of childhood, however disease burden is disproportionately higher in communities of color and of low socioeconomic status. Socio-environmental exposures, including psychosocial stressors and air pollution, are concentrated in these historically marginalized communities and contribute to asthma pathobiology through poorly understood mechanisms. Our goal is to improve our understanding of heterogeneous asthma pathobiology associated with socio-environmental exposures, relevant to marginalized populations, allowing us to better discriminate individuals at high risk for poor outcomes and identify place-based targets for intervention.

PI_NAMEs: CHRISTENSON, STEPHANIE A (contact);THAKUR, NEETA

PROGRAM_OFFICER_NAME: MORALES, JOANNELLA

PROJECT_TERMS: Acute;Adrenergic Agents;African American;Age;Air Pollutants;Air Pollution;Airway Disease;airway immune response;airway repair;Allergens;Allergic;ambient air pollution;Anti-Bacterial Agents;Asthma;asthma exacerbation;Bacteria;Blood;burden of illness;Cellular Stress;Child;Childhood;Chronic Disease;Clinical;clinically relevant;cohort;Color;Communities;community based research;Complex;Custom;Data;data integration;Disease;Disease Outcome;Emergency department visit;Enrollment;Environmental Exposure;Environmental Risk Factor;Event;fine particles;Functional disorder;Gene Expression;Glucocorticoids;Goals;Health;Heterogeneity;high risk;Hormones;Hospitalization;Human;Immune;Immune response;improved;Individual;Indoor Air Pollution;indoor pollutant;Inflammation;insight;Intervention;Latinx;Link;low socioeconomic status;marginalized community;marginalized population;Mediating;metatranscriptomics;Methods;Microbe;microbial;microbiome;Molecular;Monitor;Multiomic Data;multiple omics;nasal swab;Nitrogen Dioxide;Not Hispanic or Latino;Outcome;Pathologic;Pathology;Pathway interactions;personalized intervention;Pharmaceutical Preparations;Phenotype;pollutant;Pollution;Predisposition;Prevalence;protein expression;Psychosocial Stress;psychosocial stressors;Recovery;recruit;repaired;Research Infrastructure;resilience;Resolution;respiratory;Respiratory Tract Infections;response;Risk Factors;Role;Sampling;Signal Transduction;Site;social;Social Environment;social factors;social stressor;socioenvironmental factor;Sputum;Stable Disease;Stress;stressor;study population;Techniques;Testing;Therapeutic;transcriptomics;treatment response;Treatment/Psychosocial Effects;Viral;Virus;Vulnerable Populations;Work;Youth

PROJECT_TITLE: EXposomic Profiling in Airway disease to uNravel Determinants of disease in Asthma (EXPAND-Asthma) Center


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: HADLEY

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: NARRATIVE The prevalence of behavioral health (BH) disorders has climbed steadily among children in the U.S. over the past decade, disproportionately affecting children in lower income and minoritized populations. Access to appropriate diagnostic and treatment services for vulnerable populations is particularly challenging, but Medicaid accountable care organizations (ACOs) have the potential to address gaps in BH care for children in these populations. This study takes advantage of a natural ACO experiment taking place in Massachusetts to addresses gaps in knowledge about the effects of the accountable care ‘experiment’ on pediatric BH quality of care, utilization, outcomes, and disparities.

PI_NAMEs: GEISSLER, KIMBERLEY LYNN H;GOFF, SARAH L (contact)

PROGRAM_OFFICER_NAME: HUMENSKY, JENNIFER L

PROJECT_TERMS: 18 year old;Accountability;accountable care organization;acute care;Address;Adult;adverse childhood events;Affect;Age;aged;autism spectrum disorder;behavioral health;beneficiary;care coordination;Caring;Characteristics;Child;Child Care;Child health care;Childhood;Chronic Disease;community based service;Community Healthcare;Consultations;Contracts;COVID-19;COVID-19 pandemic;Data;Databases;Diagnosis;Diagnostic Services;Disease;Disparity;Enrollment;ethnic disparity;ethnic minority population;Evidence based treatment;experience;experimental study;Exposure to;Future;Gender;Health;health care delivery;health care disparity;health care quality;Health Insurance;health organization;Health Personnel;Health Services;Healthcare;Healthcare Systems;Heterogeneity;High Prevalence;high risk;high risk population;Hospitals;Improve Access;improved;Incentives;informant;innovation;Insurance Coverage;insurance plan;Intervention;Interview;Knowledge;Low income;low socioeconomic status;Massachusetts;Measures;Medicaid;medical specialties;member;Methods;Minority Groups;Natural experiment;novel;Organizational Models;Outcome;Ownership;Parents;Patients;pediatrician;Physicians;Policy Maker;Population;population health;Prevalence;primary care practice;primary care provider;primary care setting;Privatization;programs;Provider;Psychiatry;Quality Indicator;Quality of Care;Race;racial disparity;racial minority population;Reporting;satisfaction;Self-Injurious Behavior;Sexuality;social health determinants;social stigma;socioeconomic disparity;Surveys;Telephone;therapy development;treatment services;Vulnerable Populations

PROJECT_TITLE: Effect of Medicaid Accountable Care Organizations on Behavioral Health Care Quality and Outcomes for Children

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(90)S]


ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: PROJECT NARRATIVE Black patients receive care at lower quality hospitals and are at increased risk of patient safety events compared to White patients. Our goal is to understand the currently unknown patterns of hospital patient safety culture and its association with financial resources, other hospital characteristics, and patient safety events for hospitals that predominantly serve Black patients and compare those to hospitals that do not predominantly care for Black patients. Our work will identify any disparities in patient safety culture and explore differences in barriers to health equity, with specific attention to identifying pragmatic strategies and best patient safety practices that aim to improve patient care and reduce health inequities in hospitals.

PI_NAMEs: QUIGLEY, DENISE D. (contact)

PROGRAM_OFFICER_NAME: FREEMAN, WILLIAM

PROJECT_TITLE: Culture of Patient Safety in Black Serving and Non-Black Serving Hospitals

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Genetics;Prevention;Women's Health Research

ORG_CITY: CHARLESTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE BRCA2 is an essential player in the DNA damage response pathway preventing genome instability and cancer through proper homologous directed repair (HDR) and protection of DNA replication forks. I recently identified a novel group of BRCA2 misssense mutations which affect nuclear localization and increase sensitivity to PARP inhibitors (PARPi) and platinum drugs, but the mechanism by which this occurs is still not fully understood. The goal of my K22 proposal is to dissect the mechanisms of BRCA2 mislocalization, the altered functions of cytosolic BRCA2, and detect BRCA2 expression in human tissues as a cancer diagnostic tool.

PI_NAMEs: JIMENEZ SAINZ, JUDIT  (contact)

PROGRAM_OFFICER_NAME: HUSSAIN, SHADAB FATIMA

PROJECT_TERMS: Affect;Antibodies;Award;Biochemistry;Biological;Biology;Breast Cancer Detection;Breast Cancer gene;C-terminal;Cancer Biology;cancer cell;Cancer Diagnostics;Cancer Etiology;cancer genetics;Cancer Patient;cancer risk;Cancer-Predisposing Gene;carcinogenesis;career;Cell model;Cell Nucleus;Cellular biology;Centrosome;clinical application;Clinical Management;Cytoplasm;Cytosol;Defect;Development;diagnostic tool;DNA;DNA Binding Domain;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Gene;DNA Repair Pathway;DNA replication fork;Double Strand Break Repair;driver mutation;Ensure;Family member;Frameshift Mutation;Functional disorder;genetic testing;genome integrity;Genome Stability;Genomic Instability;Germ Lines;Goals;Hereditary Breast and Ovarian Cancer Syndrome;hereditary risk;Human;human tissue;Institution;Knowledge;Lead;Malignant Breast Neoplasm;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Melanoma;Missense Mutation;Molecular;Mutation;neoplastic cell;Nonsense Mutation;Normal Cell;novel;Nuclear;Nuclear Import;Nuclear Localization Signal;Nuclear Protein;nucleocytoplasmic transport;Pancreas;Pathogenicity;Pathway interactions;patient stratification;Patients;Pharmaceutical Preparations;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;Positioning Attribute;Postdoctoral Fellow;prevent;Prevention;Principal Investigator;Process;prostate cancer risk;protein folding;protein misfolding;Proteins;Proteomics;reconstitution;repair function;repaired;Reporting;Research;response;Risk Assessment;risk stratification;skill acquisition;success;targeted cancer therapy;targeted treatment;Testing;Therapeutic Intervention;therapy resistant;Time;Tissue Microarray;Tissue Sample;tool;trafficking;Treatment outcome;tumor;Tumor Tissue;Uncertainty;Variant;variant of unknown significance

PROJECT_TITLE: DNA repair dysfunction in cancer induced by altered BRCA2 localization

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Cancer is the second leading cause of death in the United States and 90% of deaths occur at metastatic stages. Metastasis requires the cancer cell to accomplish many distinct tasks as it moves through the body to form new tumors in distant organs. Our proposal seeks to identify systematically how a cancer cell's molecular toolkit changes during metastasis with the goal of identifying new therapeutic targets to prevent metastasis and for treating patients with metastatic disease.

PI_NAMEs: EWALD, ANDREW JOSEF (contact)

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: Age;Algorithms;Architecture;Automobile Driving;Behavior;Biological Assay;Biological Models;Birth Rate;cancer cell;cancer site;Cancerous;candidate validation;Cause of Death;cell type;Cells;Cellular Morphology;Cessation of life;Clustered Regularly Interspaced Short Palindromic Repeats;computerized tools;Data;Development;Developmental Gene;differential expression;Disease;Distant;Ecosystem;Environment;Enzymes;Epithelium;Exhibits;Genes;Genetic Transcription;Genetically Engineered Mouse;Gland;Goals;Growth;high dimensionality;high resolution imaging;Hybrids;in vivo;Invaded;Keratin;Learning;learning algorithm;life span;Link;Literature;Machine Learning;Malignant Breast Neoplasm;Malignant Neoplasms;mammary epithelium;Mammary gland;Mammary Neoplasms;Maps;Measurement;migration;Modeling;Molecular;Morphogenesis;Neoplasm Metastasis;neoplastic;new therapeutic target;Noninfiltrating Intraductal Carcinoma;Organ;patient derived xenograft model;Patient-Focused Outcomes;Patients;Periodicity;Pharmaceutical Preparations;prevent;Primary Neoplasm;Process;programs;Proteins;Publishing;Resolution;RNA;single cell sequencing;single-cell RNA sequencing;small hairpin RNA;small molecule;Source;spatiotemporal;statistics;Structure;Systems Biology;Tail;Testing;three dimensional cell culture;Time;Tissues;tool;transcriptome;transcriptomics;transfer learning;tumor;tumor progression;United States;Veins;Vimentin;Weight

PROJECT_TITLE: Mapping the single cell state basis of metastasis in space and time


ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Many low-income and minoritized children with chronic conditions live in poverty and therefore have both care coordination needs and unmet social needs, such as food insecurity and housing instability, which can lead to decreased access to care and poor health outcomes. To promote health equity and increase access to health care for low-income and minoritized children with chronic conditions, there is an urgent need for effective family-centered interventions addressing both care coordination needs and unmet social needs. The goal of this application is to develop and test the first-ever pediatric adaptation of the evidence-based Individualized Management for Patient-Centered Targets (IMPaCT) community health worker intervention, tailored to the unique needs of hospitalized children with complex chronic conditions and their caregivers.

PI_NAMEs: VASAN, ADITI  (contact)

PROGRAM_OFFICER_NAME: GRIFFIOEN, MARI

PROJECT_TITLE: Family-Centered Community Health Worker Support for Children with Chronic Conditions and Unmet Social Needs


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: NEW YORK

ORG_NAME: FLUIDDA, INC.

PHR: Project Narrative To facilitate validation of in-silico models of deposition of orally inhaled drug products, we will develop and implement protocols to conduct a deposition study using either PET or SPECT nuclear imaging. By leveraging advances in scanner technology and quantitative CT techniques, we will develop methods to produce more accurate estimates of branch-level deposition from these images than was previously possible. This data will be formatted and shared with FDA to disseminate for use by other groups to validate their in-silico models.

PI_NAMEs: BONTE, STIJN ;LAVON, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: WALENGA, ROSS

PROJECT_TITLE: A prospective study to support validation of lung deposition models with nuclear medicine imaging methods


NIH_SPENDING_CATS: Genetics;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: Public health relevance This project proposes to study the function of ubiquitin modifications in hematopoiesis. Specifically, it proposes to extend our knowledge on ubiquitination mediated by DCAF7, a protein dysregulated in blood disorders. This proposal will provide enhanced understanding of regulators of hematopoietic stem and progenitor function.

PI_NAMEs: MELO-CARDENAS, JOHANNA  (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Adult;Advisory Committees;Affect;Apoptosis;Area;Basic Science;Binding;Biochemical;Birth;Blood;blood treatment;Bone Marrow Cells;Bone marrow failure;career;Cell Cycle;Cell Death;Cell Line;Cell Maintenance;Cells;chemotherapy;Chromatin;Cleavage Under Targets and Release Using Nuclease;Complex;Cullin Proteins;Data;Development;Differentiated Gene;Disease;drug discovery;Drug Targeting;Embryo;Environment;Epigenetic Process;fetal;Fetal Liver;Future;Gene Expression;Genes;Genetic;Genetic Transcription;Goals;Hematological Disease;Hematology;Hematopoiesis;Hematopoietic;hematopoietic stem cell differentiation;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Image;Immunophenotyping;Impairment;In Vitro;in vivo;insight;Investigation;K-Series Research Career Programs;Kinetics;Knowledge;Leadership;Ligase;Maintenance;Malignant Neoplasms;Measures;Mediating;Mentors;Modification;Molecular;mouse model;Mus;Mutation;Myelogenous;novel;Oral;Phenotype;Physiological;Play;Population Dynamics;Post-Translational Protein Processing;PRC1 Protein;progenitor;programs;protein degradation;Proteins;Proteomics;proteostasis;public health relevance;Recovery;Research;Role;Running;Saint Jude Children's Research Hospital;self-renewal;single-cell RNA sequencing;skills;stem;stem cell biology;stem cell division;stem cell function;Stress;Substrate Specificity;System;Technical Expertise;Testing;Time;Training;transcriptome sequencing;Transplantation;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;ubiquitinated H2A;Ubiquitination;Writing

PROJECT_TITLE: Elucidating the role of DCAF7 on hematopoietic stem cell maintenance

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ED_INST_TYPE: SCHOOLS OF NURSING

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: This study will advance scientific knowledge in equity-focused implementation and create solutions to improve the uptake of evidence-based intervention in underserved communities through a community-engagement process. The proposed study will inform the development of equity-focused implementation strategies and examine the effectiveness of a full-scale sleep intervention that will help Black women mitigate the effects of psychological stress on their stress- related disease risk. Given the detrimental effects of psychological stress on sleep and the associated sleep health disparities among Black women, this study will contribute to significant efforts to improve public health.

PI_NAMEs: NAM, SOOHYUN  (contact)

PROGRAM_OFFICER_NAME: COA, KISHA

PROJECT_TITLE: Implementing mindfulness practice to advance sleep health equity among Black women


ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Children in families with healthcare communication in a language other than English (LOE) are at increased risk of worse asthma care and outcomes compared to those without a language barrier. The proposed research addresses the gap in knowledge about effective interventions to address asthma disparities for children in LOE families through a hybrid type 2 effectiveness-implementation trial of the Navigating Toward Equitable Asthma Management Program (Nav-TEAM) intervention which is an adaptation of evidence-based asthma navigation specifically for children in families who communicate in LOE. Our mixed methods implementation evaluation using PRISM (Practical, Robust Implementation and Sustainability Model), the contextual expansion of the RE-AIM framework with an equity lens and assessment of cost, sustainability and contextual domains will promote sustainability and scale-out of Nav-TEAM.

PI_NAMEs: DECAMP, LISA ROSS (contact);FORT, MEREDITH PARRISH

PROJECT_TITLE: Navigating Together for Equitable Asthma Management (Nav-TEAM) for Children in Families who Communicate in Languages other than English


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Eating Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Nutrition;Pediatric;Serious Mental Illness

PHR: PROJECT NARRATIVE  The proposed research will identify important interrelations among problematic social media use patterns and binge-eating disorder, using novel measures and prospective data of a large, diverse, national cohort during an important developmental period spanning early to late adolescence. The findings from this research will: (1) provide precision guidance for social media use for adolescents, parents, and clinicians to prevent binge-eating disorder; (2) inform adolescent social media use guidelines for professional societies; and (3) be disseminated through infographics, press releases, and social media based on input from youth.

PI_NAMEs: NAGATA, JASON M (contact)

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: 10 year old;18 year old;Academy;addiction;Adolescence;Adolescent;adolescent health;Adolescent Medicine;Adult;Affect;Age;American;Anxiety;Automobile Driving;Behavior;Binge Eating;Binge eating disorder;Brain;Cardiometabolic Disease;Cellular Phone;clinical application;cognitive development;cohort;Conflict (Psychology);cyberbullying;Data;Data Reporting;Development;Eating Behavior;Eating Disorders;economic cost;ethnic minority;Ethnic Origin;Focus Groups;Gender;gender minority youth;Goals;Guidelines;Health;Heterogeneity;Individual;Interview;Link;machine learning algorithm;machine learning method;Measures;media use;Mediating;Medical;Mental Depression;Mental Health;minority children;Mood Disorders;novel;Parents;Pathway interactions;Patient Self-Report;Pattern;pediatrician;Pediatrics;Personal Satisfaction;Phenotype;poor sleep;Population;Press Releases;prevent;Prevention;Professional Organizations;prospective;Prospective cohort;Questionnaires;Race;racial minority;Relapse;Reporting;Research;response;Risk;Schedule;Schizophrenia;screening;Sex Orientation;Sexual and Gender Minorities;sexual minority youth;social media;Societies;Stress;Subgroup;suicidal;Telephone;Time;Translating;Youth

PROJECT_TITLE: Investigating relationships between problematic social media use and binge-eating disorder to inform precision guidance for adolescents


ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Substance use disorders (SUDs), which can involve illicit drugs, prescription drugs, or alcohol, are common and result in substantial morbidity and mortality worldwide and in the US, and Ohio is among the states with the highest rates of SUDs. Despite the burden of illness and recommendations to screen and provide evidence-based interventions for SUDs, relatively few people who visit primary care providers are asked about substances or ever discuss it with a health professional. The STop UNhealthy (STUN) Substance Use Now Trial (STUN II) is a multisite trial aiming to evaluate the comparative effectiveness of the following strategies for improving the implementation of screening and interventions for SUDs in primary care: practice facilitation (PF), PF plus a learning collaborative (LC), PF plus performance incentives (PI), and PF+LC+PI.

PI_NAMEs: JONAS, DANIEL E (contact)

PROGRAM_OFFICER_NAME: SIMPSON, MATTHEW

PROJECT_TITLE: The STop UNhealthy Substance Use Now Trial (STUN II)


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Endocrine Disruptors;Neurosciences;Pediatric;Pregnancy;Prevention;Sleep Research;Social Determinants of Health

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: PROJECT NARRATIVE Exposure to environmental toxicants during early life development may negatively impact sleep health during adolescence. This project will examine whether mixtures of phthalates, per-/polyfluoroalkyl substances (PFAS), and metals during gestation, infancy, childhood, and adolescent development are related to poorer sleep and higher allostatic load, cumulative ‘wear and tear’ from physiological disruptions. Understanding whether environmental toxicants that are commonly found in consumer products and residential environments impact sleep characteristics may lay the foundation for novel interventions to improve health.

PI_NAMEs: SEARS, CLARA G (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: actigraphy;adequate sleep;Adolescence;Adolescent;Adolescent Development;Adrenal Glands;Adult;Age;allostasis;allostatic load;Biological;Biological Markers;Biometry;Birth;blood pressure elevation;Body Composition;cardiometabolism;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Catecholamines;Characteristics;Chemicals;Child;Childhood;cohort;consumer product;Cortisone;critical developmental period;Data;design;Development;Diet;Disease;early childhood;early life exposure;Enrollment;Environment;environmental chemical;Environmental Exposure;Environmental Health;Environmental Risk Factor;Epidemiology;Exposure to;Foundations;Glycoproteins;Goals;Growth;Hair;Health;high school;Homeostasis;Hydrocortisone;Hypertension;Hypothalamic structure;Immune;improved;improvement on sleep;indexing;Individual;infancy;Infant;Inflammation;Intervention;Joints;Knowledge;Life;Link;Longitudinal cohort;Longitudinal Studies;Measures;Metabolic;Metals;Middle School Student;modifiable risk;Morbidity - disease rate;mortality;multidisciplinary;neurobiological mechanism;Neurobiology;neurodevelopment;Neurosecretory Systems;neurotoxic;novel;Obesity;Outcome;Outcome Measure;Pathway interactions;Persons;phthalates;Physiological;Pituitary Gland;Pituitary-Adrenal System;pollutant;Poly-fluoroalkyl substances;poor sleep;postnatal;Predisposition;Pregnancy;pregnant;Pregnant Women;prenatal;Process;prospective;Prospective cohort;public health intervention;Questionnaires;Regulation;Research;Risk;Risk Factors;Risk Reduction;School-Age Population;Serum;Shapes;Sleep;sleep health;sleep quality;System;systemic inflammatory response;Testing;Toxic Environmental Substances;toxic metal;toxicant;Toxicant exposure;urinary;Visit

PROJECT_TITLE: Pre- and postnatal chemical mixture exposure, adolescent sleep health, and allostatic load

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Complementary and Integrative Health;Digestive Diseases;Prevention

ORG_CITY: HOUSTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: Project Narrative. Irinotecan is an effective chemotherapeutic agent that is widely used for the treatment of cancers that are not sensitive to other drugs. Its clinical use is severely limited by the severe diarrhea that results in poor quality of life, hospitalization and even death. The purpose of this research is to develop and test a classical Chinese Medicine formula called Xiao-Chai-Hu-Tang (with hundreds of years of recorded human use) to reduce severe diarrhea so patients will have less side effects and perhaps even better therapeutic efficacy. Both animal studies and human clinical trials are proposed to determine the mechanism(s) by which XCHT act an effective agent to alleviate irinotecan-related severe diarrhea.

PI_NAMEs: HU, MING  (contact)

PROGRAM_OFFICER_NAME: XI, DAN

PROJECT_TERMS: Animals;Antidiarrheals;Antineoplastic Agents;Atrophic;Attenuated;attenuation;Bacteria;Beta-glucuronidase;Biliary;Biological Products;cancer care;cancer therapy;Cessation of life;Chai Hu;chemotherapeutic agent;chemotherapy;Chinese;Chinese Traditional Medicine;Clinical;Clinical Research;Clinical Trials;Cyclosporine;cytokine;design;Diarrhea;dietary supplements;Dose;Double-Blind Method;Down-Regulation;Drug Exposure;Drug Kinetics;Drug Metabolic Detoxication;Drug resistance;Enzyme Activation;Enzymes;Excretory function;experience;functional restoration;Glucuronides;Glucuronosyltransferase;Goals;Hospitalization;Human;improved;In Vitro;in vivo Model;Incidence;Inflammation;Inflammatory;Intestines;Investigational Therapies;irinotecan;Malignant neoplasm of pancreas;Malignant Neoplasms;malignant stomach neoplasm;Medical;metastatic colorectal;Methods;Modeling;Mucositis;Mus;Natural Products;novel;novel strategies;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phase II Clinical Trials;Phytochemical;Plasma;preservation;prevent;Prevention;primary outcome;Prodrugs;Quality Control;Quality of life;Raloxifene;Randomized;receptor;Recovery;refractory cancer;Research;response;Running;Safety;secondary endpoint;side effect;Signal Transduction;SN-38;SN-38G;success;targeted agent;Testing;Therapeutic;Tight Junctions;Tissues;Toll-like receptors;Toxic effect;Treatment Efficacy;Treatment outcome;Villus

PROJECT_TITLE: Mechanistic and Pharmacokinetic Studies of Classical Chinese Formula Xiao Chai Hu Tang Against Irinotecan-Induced Gut Toxicities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-N(50)R]


ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Physicians prescribe and patients use antibiotics too often, but most research has focused on antibiotic prescribing that happens at visits and is focused on physician behavior. We propose a project to better understand high-inappropriate-antibiotic-utilizing patients and develop, refine, and test an intervention to address high-inappropriate-antibiotic-utilization. By addressing inappropriate antibiotic use, our goals are to improve patient care, diagnostic accuracy, and decrease inappropriate antibiotic prescribing, which would increase patient safety and limit the spread of antibiotic-resistant bacteria.

PI_NAMEs: LINDER, JEFFREY A. (contact);SZYMCZAK, JULIA E.

PROGRAM_OFFICER_NAME: MILLER, MELISSA

PROJECT_TITLE: Patient-Centered Stewardship to Improve Antibiotic Use in Ambulatory Care


ORG_CITY: BATH

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: UNIVERSITY OF BATH

ORG_ZIPCODE: BA2 7AY

PHR: DEVELOPMENT AND VALIDATION OF A MULTI-FUNCTIONAL, MULTI-PURPOSE QUANTITATIVE TOOL FOR DERMAL PHYSIOLOGICALLY-BASED PHARMACOKINETIC (PBPK) MODELING Project Narrative This project will identify a set of enhanced critical quality attributes to (a) describe topical products in their starting “as in the tube” condition, the residual film that forms after application to the skin and the kinetics of metamorphosis, (b) integrate metamorphosis events with effects of excipients and solvents on skin permeation, and (c) establish the manner in which these enhanced CQAs must be input into a PBPK model. The outcome will be an enhanced, validated and mechanistic dermal PBPK model that can predict the performance of topical products and support bio(in)equivalence decisions.

PI_NAMEs: DELGADO-CHARRO, M. BEGONA  (contact)

PROGRAM_OFFICER_NAME: TSAKALOZOU, ELEFTHERI

PROJECT_TITLE: Development and Validation of a Multi-functional, Multi-purpose Quantitative Tool for Dermal Physiologically-Based Pharmacokinetic Modeling


ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Ambulatory diagnostic error is a vexing problem because events unfold across time with shifting team members, and accurate and timely diagnosis relies on keeping patients and health care professionals (HCPs) on the same page, both in and between clinic visits. Yet little is known about how patients and HCPs develop and sustain a shared mental model of the diagnostic process. We will identify the specific teaming behaviors that help patients and HCPs to coproduce safety at known diagnostic process risk points, and then develop and disseminate tools to support patients, care partners, interpreters and clinicians as active contributors to the diagnostic process.

PI_NAMEs: BELL, SIGALL ;THOMAS, ERIC J (contact)

PROGRAM_OFFICER_NAME: COSBY, KAREN

PROJECT_TITLE: Safety II Together: Coupling teaming science with patient engagement and health information transparency to coproduce diagnostic excellence


ADMINISTERING_IC: AG

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Physical Rehabilitation;Rehabilitation;Sarcopenia;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE Impaired recovery from skeletal muscle disuse in aging results in heightened risk of disability and falls contributing to decreased healthspan. During the F99/K00 phases, I will study the mechanisms of novel therapeutic compounds and cellular interactions to promote muscle recovery in aged mice. This proposal will be guided by a panel of muscle aging experts and training experiences across various disciplines and institutions to promote my training in muscle aging research.

PI_NAMEs: PETROCELLI, JONATHAN JOSEPH (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Acceleration;Activities of Daily Living;age-related disease;Aging;aging population;Area;Biochemical;Biology;Biomedical Research;blood glucose regulation;Burn injury;career;Cell Aging;Cell Communication;Cell Proliferation;cell type;Cells;Clinical;Clinical Trials;Coculture Techniques;Collagen;Combined Modality Therapy;Data;deconditioning;Deposition;design;Development;disability;disability risk;Discipline;Disuse Atrophy;Doctor of Philosophy;Dose;effectiveness evaluation;effectiveness testing;Ensure;Equilibrium;experience;experimental study;Exposure to;Extracellular Matrix;fall risk;falls;Fellowship;Fibroblasts;Fibrosis;Functional disorder;Funding;Genetic;genetic manipulation;Goals;Grant;Health;healthspan;Hindlimb Suspension;Hospitalization;Impairment;improved;In Vitro;in vivo;Individual;Injury;innovation;Institution;interest;Intervention;Kentucky;Knowledge;Laboratories;Leadership;Learning;Leucine;Logistics;Mediating;Mentors;Mentorship;Metabolism;Metformin;Methods;Morbidity - disease rate;mouse model;multidisciplinary;Mus;Muscle;muscle aging;Muscle Cells;Muscle Fibers;muscle hypertrophy;muscle regeneration;Muscle satellite cell;muscle strength;Muscle Weakness;Muscular Atrophy;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Nutraceutical;old mice;older adult;Older Population;outreach;Pain;Pharmacologic Substance;Phase;physical inactivity;Physical Rehabilitation;Postdoctoral Fellow;Posture;pre-clinical research;preclinical trial;preservation;professor;Recovery;Research;Role;Running;sarcopenia;Series;Signal Transduction;SIRT1 gene;Skeletal Muscle;skills;stem;synergism;Techniques;Testing;Therapeutic;Therapeutic Agents;therapeutic evaluation;tool;Training;translational approach;translational therapeutics;Translations;United States National Institutes of Health;Universities;Utah;Work;Writing

PROJECT_TITLE: Elucidating the Mechanisms of Translational Approaches to Enhance Recovery of Aged Muscle


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Mental Health;Neurodegenerative;Neurosciences

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Brains from Alzheimer’s patients often display loss of 5-HT neurons, but the causal relationship of this 5-HT dysregulation and Alzheimer’s symptoms is unclear. In the proposed research, we will determine whether the dysregulated 5-HT→hippocampus circuit contributes to the cognitive and neuropsychiatric symptoms in AD and further test whether a 5-HT receptor (5-HT2CR) is a suitable target for therapeutic interventions.

PI_NAMEs: XU, YONG  (contact)

PROGRAM_OFFICER_NAME: PETANCESKA, SUZANA

PROJECT_TERMS: Age;Aggressive behavior;Aging;Agonist;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Amyloid;Anger;Area;Biological Availability;Biology;Brain;brain dysfunction;Caring;Cognition;Cognitive;Cognitive deficits;Denervation;Disease Progression;Economic Burden;effective therapy;Epidemic;gain of function;Genes;Genetic;genetic approach;genetic manipulation;Health;Hippocampus;Human;Impaired cognition;Impairment;improved;Individual;Knock-in;Knock-in Mouse;loss of function;Memory impairment;Memory Loss;Midbrain structure;Modeling;Moods;mouse model;Mus;Mutant Strains Mice;Mutation;Neurobehavioral Manifestations;Neurobiology;Neuronal Plasticity;Neurons;neuropsychiatric symptom;neuropsychiatry;novel therapeutic intervention;overexpression;Pathogenesis;Pathogenicity;Patients;pharmacologic;Phenotype;Physiological;Pilot Projects;Point Mutation;Population;pre-clinical;receptor;Receptor Signaling;Regulation;Reporting;Research;Role;Serotonin;serotonin receptor;Signal Transduction;Site;social;Social Behavior;Symptoms;targeted treatment;tau-1;Testing;Therapeutic Intervention;Time

PROJECT_TITLE: 5-HT 2C Receptor and Alzheimer's Disease

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Autoimmune Disease;Brain Disorders;Dementia;Digestive Diseases;Inflammatory Bowel Disease;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Traumatic brain injury (TBI) causes chronic neuroinflammation with progressive neurodegeneration leading to long-term neurocognitive dysfunctions including dementia and emerging evidence suggests that bi-directional brain-systemic interactions contribute to these neuropathological changes. Notably, TBI causes gastrointestinal (GI) tract pathology and GI diseases are associated with neurological dysfunctions. We propose that, TBI and colitis synergize to promote the development of chronic neurodegenerative processes, causing delayed central inflammation, hippocampal neuronal loss and neurobehavioral dysfunctions, the proposed studies will probe the novel concept that therapeutic strategies that target GI tract mechanisms may limit brain disease processes including neurodegeneration and thus attenuate chronic cognitive decline after TBI.

PI_NAMEs: FADEN, ALAN IRA (contact);STOICA, BOGDAN ADRIAN

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Acute;Affective;Alleles;Alzheimer's Disease;Alzheimer's disease related dementia;Animals;Apolipoprotein E;Attenuated;Brain;Brain Diseases;Brain Pathology;Cells;Central Nervous System;cholinergic;Chronic;Chronic Phase;Clinical Research;clinically relevant;Cognition;Cognitive deficits;cognitive function;Cohort Studies;Colitis;Colon;Colon Injury;Communication;comparison control;controlled cortical impact;Data;Dementia;designer receptors exclusively activated by designer drugs;Development;Disease;Dysautonomias;Electrocardiogram;Encephalitis;Engineering;Enteral;enteric infection;Enteric Nervous System;Environment;Equilibrium;Functional disorder;G-Protein-Coupled Receptors;gastrointestinal;Gastrointestinal Diseases;Gastrointestinal tract structure;Genetic;genetic approach;genetic risk factor;glial activation;gliogenesis;gut homeostasis;gut-brain axis;Hippocampus;Homeostasis;Human;Immune;Immune response;Impaired cognition;Impairment;improved;Individual;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;Injury;Intervention;intestinal barrier;Intestines;Late Onset Alzheimer Disease;Memory;Microglia;mild traumatic brain injury;Modeling;Molecular;motility disorder;Motor;Mucous Membrane;Mus;Nerve Degeneration;neurobehavioral;Neurocognitive;Neurocognitive Deficit;Neurodegenerative Disorders;Neuroglia;neuroinflammation;Neurologic Deficit;Neurologic Dysfunctions;neuron loss;neuropathology;neurotoxic;novel;overexpression;Pathologic;Pathology;Pathway interactions;Patients;permissiveness;pharmacologic;Phenotype;Play;Point Mutation;Population;population based;Predisposition;Process;progressive neurodegeneration;protective effect;receptor;Regulation;Reporting;Resistance;response;Risk;Risk Factors;Role;Severities;sex;small molecule;synergism;Therapeutic;Tissues;transcutaneous stimulation;Trauma patient;Traumatic Brain Injury;TREM2 gene;Vagus nerve structure

PROJECT_TITLE: Bidirectional Brain-Gut interactions, chronic neuroinflammation and neurodegeneration after traumatic brain injury

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: PROJECT NARRATIVE Native Ion Mobility-Mass Spectrometry (IM-MS) can reveal a wealth of information about the structure of biomolecules and their complexes, especially when combined with activation methods used to disrupt physiological structures and expose their more detailed architecture. Short-term goals of the proposed research include developing theory and experimental methods to boost the power of these methods by relating activation energies and entropies to structural information. The long-term goal of the proposed research is to provide academic, pharmaceutical, and clinical researchers with robust experimental and computational tools needed to quantitatively analyze structure and behavior of biomolecules relevant to human health while harnessing the specificity, sensitivity, speed, and tolerance to heterogeneity of native IM-MS.

PI_NAMEs: PRELL, JAMES STEPHEN (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TITLE: Quantitative Determination of High-Order Protein Structure with Native Ion Mobility-Mass Spectrometry and Computational Chemistry

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Bioengineering;Cancer;Genetics;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative The use of α-emitting radionuclides is rapidly growing as a promising approach to treat several types of cancer and metastases. In these radiation-based treatments, maximizing efficacy while minimizing non-desired toxicities is only achievable through an accurate knowledge and prediction of the α radiation interaction with the organism. This project will contribute decisively to a rigorous and complete determination of the radiation dosimetry and biological effects of α-particles in the context of radiopharmaceutical treatments.

PI_NAMEs: BERTOLET REINA, ALEJANDRO  (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: absorption;Affinity;Alpha Particles;analytical method;Animal Model;Antineoplastic Agents;Beta Particle;Binding;Biodistribution;Biological;Blood;Blood flow;cancer cell;cancer type;Cell Line;Cell model;Cells;Chemicals;Childhood;clinical application;clinical effect;Collaborations;Complex;Data;Deposition;Disease;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;Dose;Dose Limiting;dosimetry;Electrons;Energy Transfer;enhancing factor;Ensure;Event;experience;Foundations;Gamma Rays;Grant;high risk;Human;Hypoxia;Impairment;In Vitro;in vivo;interest;Investigation;irradiation;Knowledge;Laboratories;Leadership;Learning Skill;Length;Ligands;Liquid substance;Location;Lymphocyte;Malignant Neoplasms;Mentors;Metastatic Neoplasm to the Bone;method development;Methods;Microscopic;Modality;Modeling;Monte Carlo Method;Neoplasm Metastasis;neoplastic cell;Neuroblastoma;neuroblastoma cell;Normal tissue morphology;Organ;Organism;overexpression;particle;Pattern;Pennsylvania;Phase;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Positioning Attribute;Prediction of Response to Therapy;Principal Investigator;Prognosis;Proteins;Publishing;Radiation;radiation absorbed dose;Radiation Dose Unit;radiation effect;Radiation Interaction;Radiation therapy;Radiation Tolerance;Radiobiology;Radioisotopes;Radiometry;Radiopharmaceuticals;Relative Biological Effectiveness;repaired;Research;response;Roentgen Rays;Running;side effect;simulation;Site;skills;Solid Neoplasm;Structure;Subcellular structure;symposium;Techniques;theories;Tissues;tool;Toxic effect;Treatment outcome;tumor;Universities;uptake;Variant;Water;Writing;Xenograft Model

PROJECT_TITLE: Radiation dosimetry for alpha-particle radiopharmaceutical therapy and application to pediatric neuroblastoma


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Rehabilitation

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative White matter deep brain stimulation is a rapidly developing therapy for individuals with treatment resistant neurological and psychiatric disorders. Despite this, little is known about the specific anatomical and functional mechanisms that are engaged when stimulation is applied in this way. Here we will address these issues using a combination of resting-state fMRI, diffusion tractography, multi-site neurophysiology, and postmortem anatomical analysis in macaques.

PI_NAMEs: MAYBERG, HELEN S;RUDEBECK, PETER  (contact);RUSS, BRIAN E

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Acute;Affect;Affective;Anatomy;Anisotropy;Anterior;Anxiety Disorders;Area;Attention;Autopsy;Brain;Brain Diseases;Cell Nucleus;Chronic;cingulate cortex;Clinical;Communication;Confocal Microscopy;Data;Deep Brain Stimulation;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Dorsal;Electrodes;Electron Microscopy;Experimental Designs;experimental study;Fascicle;Forcep;frontal lobe;Functional Magnetic Resonance Imaging;Goals;gray matter;Human;Image;Implant;Individual;insight;interdisciplinary approach;interest;Knowledge;Location;Macaca;Measures;Mental disorders;Microscopy;Minor;Modeling;Modification;Monkeys;Mood Disorders;Motor;Movement;multimodality;myelination;Nervous System Disorder;neural;neural circuit;Neurodegenerative Disorders;Neurologic;neurophysiology;novel;Oligodendroglia;Parkinson Disease;Pathway interactions;Patients;Persons;Population;Process;Proliferating;Protocols documentation;reduce symptoms;Reporting;Resistance;Resolution;Rest;Rodent Model;Site;Structure;Structure of subthalamic nucleus;System;targeted treatment;Testing;Thalamic structure;theories;Therapeutic;Therapeutic Effect;Therapeutic Intervention;therapy development;Time;tractography;translational approach;white matter;Work

PROJECT_TITLE: Establishing the anatomical and functional mechanisms of white matter deep brain stimulation

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cachexia;Prevention

ORG_CITY: HUNTSVILLE

ORG_NAME: SAM HOUSTON STATE UNIVERSITY

PHR: PI Name: Mardelle Atkins Commons ID: MRATKINS Project: Assessing if tumor induced muscle cachexia is initiated by defects in Myosin Heavy Chain production and localization in a Drosophila tumor model Narrative Cancer induced wasting, or cachexia, negatively impacts patient treatment, quality of life and survival. However, we do not understand how or when this complex process begins, and can only diagnose it at later stages. Using a basic research model this research will characterize the earliest changes in muscles leading to cachexia and investigate how they result in eventual muscle loss.

PI_NAMEs: ATKINS, MARDELLE RENEE (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Affect;Automobile Driving;Basic Science;Body part;Body Weight;Cachexia;Cancer Cachexia;Cancer Etiology;Cancer Model;Cancer Patient;carcinogenesis;Cells;Cellular Stress;Cessation of life;Chronic;Clinic;Clinical;Communities;Complex;cost;Coupled;Data;Defect;Development;Diagnosis;Diagnostic;Dietary Intervention;Disease;Distant;Drosophila genus;Early Diagnosis;Endocrine;Ethics;Event;Family member;Fatty acid glycerol esters;Foundations;Future;Genetic;genetic approach;genetic manipulation;Goals;Image;Immune System Diseases;in vivo;insight;Intervention;Laboratories;Larva;Learning;Malignant Neoplasms;Master of Science;Metabolic;Microtubules;Modeling;Molecular Chaperones;mouse model;Mus;Muscle;Muscle Fibers;Muscle Weakness;Muscular Atrophy;Myosin ATPase;Myosin Heavy Chains;Myosin Light Chains;Names;novel;Nuclear;Organ;Outcome;Pathology;Pathway interactions;Patients;Phenotype;prevent;Process;Production;programs;protein folding;protein transport;psychologic;Publishing;Quality of life;Refractory;Research;Research Personnel;Resolution;response;Sarcomeres;Signal Pathway;skeletal muscle wasting;Speed;Stains;Stereotyping;Stress;Students;Syndrome;System;Systemic disease;Testing;Time;Tissues;tool;Training;transcriptomics;tumor;undergraduate student;wasting;Work


NIH_SPENDING_CATS: Cardiovascular;Contraception/Reproduction;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Pregnancy;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative The Multi-Omics for Maternal Health after PE (MOM-Health) Disease Study Site aims to use multi-omic analyses of biosamples matched with comprehensive clinical and demographic information and measures of environmental exposures before and after delivery to uncover mechanisms leading from preeclampsia and other hypertensive diseases of pregnancy to cardiovascular disease following delivery in a diverse population. Knowledge resulting from this project can be used to develop strategies to predict patients at risk for later cardiovascular disease and to develop preventative therapies, improving postpartum maternal health in those most at risk for long-term morbidity and mortality.

PI_NAMEs: JACOBS, MARNI ;LAURENT, LOUISE CHANG (contact)

PROGRAM_OFFICER_NAME: MORALES, JOANNELLA

PROJECT_TERMS: 37 weeks gestation;Academic Medical Centers;Adherence;Affect;American Indian Women;Animals;biobank;Black American;Black Populations;Blood Pressure;Blood specimen;Cardiovascular Diseases;Cell Nucleus;Cells;Cessation of life;Chronic;Clinical;clinical phenotype;Collaborations;Collection;Communities;community engagement;Computer Models;Consent;Coupled;Data;Data Analyses;data sharing;Death Rate;Developed Countries;Disease;disorder subtype;Disproportionately impacts women;Enrollment;Environmental Exposure;epigenomics;Ethnic Population;experience;fetal;fitness;Funding;Genetic;genome sequencing;Genomics;Gestational Age;Goals;Grant;Health;Heterogeneity;high risk;Hispanic Americans;Hispanic Populations;Home;Hospitalization;Hypertension;improved;in vitro Model;Infrastructure;knowledge of results;Link;lipidomics;Machine Learning;Maternal Health;maternal morbidity;Maternal Mortality;Measurement;Measures;metabolomics;method development;Methods;Molecular;Monitor;Morbidity - disease rate;mortality;Multiomic Data;multiple omics;novel;Outcome;Participant;Patients;personalized approach;Phenotype;Physiological;Physiology;Placenta;Plasma;Population;Population Heterogeneity;Postpartum Period;Pre-Eclampsia;Pregnancy;Pregnancy Complications;pregnancy disorder;pregnancy hypertension;pregnancy related death;Pregnancy Trimesters;preventable death;Preventive therapy;Production;Proteomics;protocol development;racial population;Recontacts;recruit;Research Personnel;research study;Resources;Risk;risk stratification;Sample Size;Second Pregnancy Trimester;Serum;Site;social health determinants;Source;stem;Study Subject;Testing;Tissues;transcriptome sequencing;transcriptomics;trend;Umbilical Cord Blood;United States National Institutes of Health;Urine;Visit;Whole Blood;whole genome;Woman

PROJECT_TITLE: Multi-Omics for Maternal Health after Preeclampsia


ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative People insured by Medicaid with co-occurring serious mental illness (SMI) experience significant disparities following non-psychiatric hospitalizations. Our previously developed post discharge support pathway has successfully reduced post hospitalization disparities, though its benefits for patients diagnosed with SMI are unknow. This study seeks to adapt, implement, and evaluate the THRIVE post discharge support clinical pathway to determine if the invention benefits people insured with Medicaid with and without SMI equally and to evaluate the organizational features that support its successful implementation.

PI_NAMEs: BROOKS CARTHON, JACQUELINE MARGO (contact)

PROGRAM_OFFICER_NAME: FREEMAN, WILLIAM

PROJECT_TITLE: An equity-focused intervention to improve care transitions for Medicaid insured individuals with co-occurring serious mental health


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

PHR: Project Narrative Gadolinium-based contrast agents (GBCAs) used with MRI provide critical insights for disease diagnosis and staging, with over 12 million of administrations annually in the US. This proposal aims to address safety concerns surrounding the use of GBCAs and the long-term retention of gadolinium in tissues. Our goal is to develop a quantitative, non-invasive and sensitive PET/MRI technique to help understand the fate of GBCAs in vivo and to monitor biochemical processes using responsive contrast agents.

PI_NAMEs: LE FUR, MARIANE  (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Address;Aneurysm;Autopsy;Bicarbonates;Biochemical Process;Biological;Biology;Blood Vessels;bone;Brain;cancer imaging;chelation;chemical stability;Chemical Structure;Chemicals;chemotherapy;Chromatography;clinically significant;Contrast Media;Coupled;Deposition;Development;Diagnostic radiologic examination;disease diagnosis;Doxorubicin;Drug Kinetics;Drug or chemical Tissue Distribution;Electron Microscopy;Electron Spin Resonance Spectroscopy;Elements;Excision;Excretory function;experience;extracellular;Fibrosis;Gadolinium;Glucose;Goals;Heart;Human;human tissue;Image;In Vitro;in vivo;insight;Kidney Neoplasms;liver biopsy;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;mass spectrometric imaging;Mass Spectrum Analysis;Measurement;Measures;Methods;Microelectrodes;Microscopic;Modeling;molecular imaging;Monitor;Multiple Sclerosis;Nephrectomy;Nephrogenic Systemic Fibrosis;next generation;Operative Surgical Procedures;Organ;Output;Pain;Pathologic;Patients;Positron-Emission Tomography;pre-clinical;Predisposition;Prognosis;Property;Protocols documentation;Radiochemistry;Radiolabeled;Rattus;Renal function;Reporting;Research;response;Rodent;Safety;Sampling;skills;Skin;Staging;Stimulus;Symptoms;Techniques;Tissue Sample;Tissues;tool;Toxic effect;Training;treatment response;tumor;Tumor Markers;tumor metabolism;Work;Yttrium

PROJECT_TITLE: Quantification of whole-body distribution and speciation of gadolinium-based contrast agents by Y-86 PET/MRI


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: COLLEGE STATION

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: RELEVANCE (See instructions): At the completion, the improved fundamental understanding of heterogeneous cellular processes will  ultimately contribute to improved strategies for disease diagnosis, treatment, and prevention, and  improvement of quality of life.

PI_NAMEs: NI, YANG  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: analytical tool;Bayesian Modeling;Bayesian Network;causal variant;Cell Differentiation process;Cell Physiology;cell type;Cells;Comparative Study;Complex;Computing Methodologies;Data;design;Development;disease diagnosis;disorder subtype;Etiology;experimental group;Feedback;Gene Expression Regulation;gene regulatory network;Genes;Genetic Markers;Goals;Graph;improved;Instruction;Intervention;Methodology;Methods;Modeling;Molecular;Monitor;Morphology;Nature;network models;novel;Pathologic;Periodicity;Prevention;Quality of life;Research;response;Sampling;semiparametric;single-cell RNA sequencing;Statistical Methods;Statistical Models;Techniques;Tissues;tool;treatment group;Validation

PROJECT_TITLE: Bayesian Differential Causal Network and Clustering Methods for Single-Cell Data


FUNDING_MECHANISM: RESEARCH CENTERS

PHR: Narrative Lack of progress in curing metastatic breast cancer is due to a number of fundamental treatment barriers. These include insufficient knowledge of therapeutic vulnerabilities, lack of reliable predictive biomarkers, inability to target common tumor suppressor gene loss, inability to target oncogenes that are not protein kinases or ligand- dependent transcription factors, resistance due to clonal evolution and tumor heterogeneity, and failure to mount an immune response against the tumor. Here we articulate cross-cutting objectives and aligned approaches that increase the efficiency of core utilization and promote inter-project collaboration.

PI_NAMEs: ZHANG, XIANG  (contact)

PROGRAM_OFFICER_NAME: BASA JANAKIRAM, NAVEENA

PROJECT_TERMS: Academia;advanced breast cancer;Advocacy;Advocate;Anatomy;Articulation;Big Data;biobank;Bioinformatics;Biological Assay;Biological Markers;Biology;Biostatistics Core;Board Certification;Breast Cancer Patient;Cancer Biology;career;Cementation;clinical translation;Clinical Trials;Clonal Evolution;Collaborations;college;Common Neoplasm;convict;Data Analyses;Dedications;derepression;design;Development;Diagnostic;diagnostic tool;Disease;drug development;drug repurposing;early phase clinical trial;Eligibility Determination;Ensure;Environment;Equipment;Estrogen receptor positive;experience;Experimental Pathology;Failure;Funding;Future;Genetic Screening;Grant;Human Resources;Immune response;Immunologics;Industry;Informatics;inhibitor;innovation;Investments;Knowledge;Leadership;Ligands;Malignant Breast Neoplasm;Medicine;member;Metastatic breast cancer;Mission;Molecular;Molecular Epidemiology;Monitor;Morbidity - disease rate;mortality;multidisciplinary;Myeloid-derived suppressor cells;Neoplasm Circulating Cells;NF1 gene;NF1 tumor suppressor;novel therapeutic intervention;novel therapeutics;Oncogenes;Outcome;Pathologist;Pathology;Pathway interactions;Phase;Phase III Clinical Trials;phase III trial;Phosphotransferases;Population;Precision Medicine Initiative;predictive marker;Productivity;programs;prospective;Protein Kinase;proteogenomics;Protocols documentation;PTPN12 gene;Qualifying;randomized trial;recruit;Research;Resistance;Resources;Scientist;Stratification;Structure;Techniques;technological innovation;Therapeutic;transcription factor;Translational Research;Treatment Protocols;triple-negative invasive breast carcinoma;tumor;tumor DNA;tumor heterogeneity;Tumor Immunity;tumor immunology;Tumor Suppressor Genes;Tumor Suppressor Proteins;Tumor-Infiltrating Lymphocytes

PROJECT_TITLE: Translational Research in Breast Cancer


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

PHR: NARRATIVE  The Administrative Core is charged with facilitating communication and sustaining integration among the SPORE members and projects, as well as providing efficient support services for all of the SPORE components, in order to maximize synergy in achieving our translational research goals

PI_NAMEs: ELLIS, MATTHEW J (contact)

PROJECT_TERMS: Administrative Personnel;Advocacy;Advocate;Breast;career;career development;Charge;Clinical Trials;Communication;Conflict of Interest;cost effective;Development;experience;Funding;Goals;Grant;Human Resources;human subject;improved;Individual;Institution;Institutional Review Boards;Malignant Breast Neoplasm;meetings;member;Minor;Monitor;Preparation;Principal Investigator;programs;Protocols documentation;Quality Control;Recommendation;recruit;Regulation;Reporting;Research Personnel;Research Project Grants;Resources;Services;symposium;synergism;Training;Translational Research;Travel;United States National Institutes of Health;Visit

PROJECT_TITLE: Administration and Advocacy


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Women's Health Research

PHR: Narrative The Pathology and Biobanking Core seeks to improve the lives of breast cancer patients by facilitating novel translational biomarker discovery into the development and validation of clinical assays. This Core serves as a centralized repository for biospecimen acquisition and use, management of the histopathology activities of each SPORE project, and the development and validation of biomarker-based molecular testing that supports all stages of SPORE project development.

PI_NAMEs: MILES, GEORGE  (contact)

PROJECT_TERMS: Advocacy;anti-cancer research;assay development;biobank;Biological Assay;Biological Specimen Banks;biomarker discovery;biomarker validation;Breast;Breast Cancer Patient;career development;Certification;Clinical;Clinical Trials;Collaborations;Collection;college;Computer software;data warehouse;Dedications;design;Development;diagnostic platform;digital;digital imaging;Drug or chemical Tissue Distribution;Education;Ensure;experimental analysis;Funding;Genomics;histological studies;Histopathology;Human;Human Resources;imaging capabilities;Immunofluorescence Immunologic;Immunohistochemistry;improved;Informatics;Institution;Laboratories;Malignant Breast Neoplasm;Medicine;Microdissection;Microfluidics;microscopic imaging;Molecular;molecular diagnostics;next generation sequencing;novel;Pathology;Pilot Projects;Precision Medicine Initiative;Preparation;prospective;Proteomics;Reporting;repository;Research Personnel;Resource Sharing;Resources;Services;Specimen;statistics;Structure;Techniques;Testing;Tissue Microarray;Tissues;Translational Research;Validation;Work

PROJECT_TITLE: Pathology and Biobanking


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Services;Human Genome;Networking and Information Technology R&D (NITRD);Women's Health Research

PHR: PROJECT NARRATIVE This Core provides comprehensive and essential statistical, bioinformatics, medical informatic and data management support to all projects, to the DRP and CEP and to the other Cores. Our mission is to bring the best possible methods to bear, and to help ensure that the translational goals of the SPORE will be met while making efficient use of resources.

PI_NAMEs: HILSENBECK, SUSAN G. (contact)

PROJECT_TERMS: biobank;Bioinformatics;biomedical informatics;Biometry;Cancer Center;Clinical;Clinical Trials;Collaborations;college;Complex;Comprehensive Cancer Center;Computational Biology;Computer software;Computerized Medical Records Systems;Consultations;cost effectiveness;Cost Sharing;Data;Data Analyses;data management;Data Management Resources;Data Reporting;data sharing;Database Management Systems;Databases;Dedications;design;Development;Ensure;experience;Experimental Designs;experimental study;Fertilization;flexibility;Genomics;Human Resources;Informatics;informatics shared resource;Institution;Licensing;Maintenance;Malignant Breast Neoplasm;Medical Informatics;Medicine;member;Methods;Mission;Names;Pathology;pre-clinical;Productivity;proteogenomics;Proteome;Randomized;Research Personnel;Resources;Sample Size;Science;Services;skills;statistics;Testing;tool;translational goal;Translational Research

PROJECT_TITLE: Biostatistics, Information, and Computational Biology


ADMINISTERING_IC: OD

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: COLUMBIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: PROJECT NARRATIVE: OVERALL COMPONENT This project addresses an unmet need for essential services related somatic cell genome editing. This project will provide models that recapitulate human conditions and harbor human target sequences. Further, this project will provide testing services to evaluate safety and efficacy of potential therapeutic strategies.

PI_NAMEs: GREEN, JONATHAN A;WELLS, KEVIN DALE (contact)

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Address;Animal Experiments;Animal Model;Animal Testing;Animals;Basic Science;biosafety level 2 facility;Breeding;Clinic;clinically relevant;cohort;Collaborations;Communication;Communities;comparative;Cryopreservation;Data Storage and Retrieval;Development;Discipline;Effectiveness;efficacy evaluation;Emerging Technologies;Ensure;Evaluation;experience;Family suidae;Fee-for-Service Plans;Foundations;Funding;Future;Genes;Genetic;genetic resource;Genome;genome editing;Germ Lines;Goals;Housing;Human;human disease;human model;immunogenicity;Impact evaluation;in vivo;Income;Individual;Inflammation;Infrastructure;Logistics;Maintenance;Methods;Mission;Modeling;new therapeutic target;novel;novel therapeutic intervention;Physiological;porcine model;preservation;Procedures;Process;Production;programs;Reagent;reduce symptoms;Reporter;Reporting;Research;Resources;Role;Safety;Services;somatic cell gene editing;Standardization;System;Technology;Testing;testing services;Therapeutic;Therapeutic Intervention;therapy duration;tool;translational therapeutics;United States National Institutes of Health

PROJECT_TITLE: Swine Somatic Cell Gene Editing Testing Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-V(50)R]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Estrogen;Genetics;Neurofibromatosis;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Women's Health Research

PHR: PROJECT NARRATIVE Estrogen receptor-positive breast cancer is the largest contributor to death from breast cancer, which now  exceeds a half million annually worldwide. The major cause of death is resistance to treatment. Therefore,  this project aims to study a powerful resistance driver, neurofibromin (encoded by the NF1, neurofibromatosis  type 1, gene), to define its role in resistance and to seek a vulnerability that can be targeted to greatly improve  treatment efficacy and enhance patient survival.

PROJECT_TERMS: Acceleration;Address;adjuvant endocrine therapy;Aftercare;aggressive breast cancer;Agonist;Alleles;Alternative Therapies;anastrozole;arm;Aromatase Inhibitors;Automobile Driving;Biological Assay;biomarker selection;Breast Cancer Cell;breast cancer diagnosis;Breast Cancer Patient;Cause of Death;Cell Survival;Cells;Cessation of life;Clinical;clinical development;Clinical Research;Clinical Trials;Clinical Trials Design;Data;deprivation;Diagnosis;Diagnostic tests;digital;Disease;Disease Resistance;DNA;DNA Sequence Alteration;Drug Targeting;Drug usage;efficacy evaluation;Endocrine;Endocrine System Diseases;ERBB2 gene;ESR1 gene;Estradiol;Estrogen deficiency;Estrogen receptor positive;FDA approved;Frameshift Mutation;Fulvestrant;Gene Expression;Generations;Genes;genetic corepressor;Genetic Transcription;Growth;GTPase-Activating Proteins;Heterogeneity;hormone therapy;Hypersensitivity;Immunofluorescence Immunologic;Immunohistochemistry;improved;Individual;inhibitor;inhibitor therapy;interest;kinase inhibitor;Letrozole;Malignant Breast Neoplasm;Mammary Neoplasms;Mass Spectrum Analysis;MEKs;Messenger RNA;Methodology;Molecular;mutant;Mutation;mutational status;Neoadjuvant Therapy;Neoplasm Circulating Cells;Neurofibromatosis 1;NF1 gene;Nonsense Mutation;Oral;Outcome;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Phase II Clinical Trials;phase II trial;Phosphotransferases;pre-clinical;Pre-Clinical Model;predictive marker;Proteomics;Protocols documentation;Randomized;randomized trial;Ras Inhibitor;Ras/Raf;Repression;Research;Resistance;resistance mechanism;response;RNA analysis;Role;Sampling;Signal Transduction;stem;Tamoxifen;Technology;Testing;Therapeutic;therapy resistant;transcriptome sequencing;Translational Research;Treatment Efficacy;treatment optimization;Treatment Protocols;treatment response;trial comparing;tumor;Tumor Suppressor Genes

PROJECT_TITLE: Project 1: Co-Targeting ER and Kinome Deregulation in Breast Cancers with Neurofibromin Deficiency


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Women's Health Research

PHR: PROJECT NARRATIVE Our proposal aims to develop new strategies to combat a common and aggressive subtype of human breast  cancer (triple-negative breast cancer, or TNBC). We recently discovered a new mechanism that contributes to  the coordinate hyperactivation of RTKs in TNBC and invokes a new therapeutic entry point through which to  target these cancers. We propose to translate these preclinical findings into a new therapeutic approach by  evaluating the efficacy of the well-tolerated RTK inhibitor sitravatinib as monotherapy in metastatic TNBC  patients, assessing sitravatinib in combination with standard of care taxane chemotherapy, and capitalizing on  the pro-immune effects of sitravatinib in combination with immune checkpoint therapies.

PI_NAMEs: WESTBROOK, THOMAS  (contact)

PROJECT_TERMS: Breast Cancer Patient;breast cancer progression;checkpoint therapy;chemotherapy;Chronic;Clinical Research;combat;Data;Dependence;efficacy evaluation;Exhibits;Genome;Human;Hyperactivity;Immune;In Vitro;inhibitor;Knowledge;Malignant Breast Neoplasm;Malignant Neoplasms;Mutate;next generation;novel therapeutic intervention;novel therapeutics;Oncogenic;PDGFRB gene;pre-clinical;Pre-Clinical Model;preclinical study;Protein Tyrosine Phosphatase;Proteome;PTPN12 gene;receptor binding;restraint;Signal Transduction;standard of care;taxane;Therapeutic;therapeutic target;Translating;Translational Research;triple-negative invasive breast carcinoma;tumor;Tumor Suppressor Proteins

PROJECT_TITLE: Project 2: Targeting RTK Co-Dependencies in Triple-Negative Breast Cancer


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Immunotherapy;Women's Health Research

PHR: NARRATIVE After the introduction of successful HER2 directed therapeutics, most fatal cases of breast cancer are associated with chemotherapy-insensitive triple-negative or luminal B breast cancer. Our research will  establish endoplasmic reticulum stress sensor IRE1-targeted therapy as a novel therapeutic approach to  enhance chemotherapy sensitivity and reverse the immunosuppressive microenvironment in the presence of  chemotherapy that sensitizes MYC-driven breast cancers to immune checkpoint intervention.

PI_NAMEs: CHEN, XI  (contact)

PROJECT_TERMS: Adjuvant Study;advanced disease;Animals;anti-PD-L1;Antibodies;biological adaptation to stress;Biological Assay;Biopsy;Breast Cancer Model;Breast Cancer Patient;Cancer and Leukemia Group B;career;chemotherapy;Clinical;Clinical Trials;cohort;Combined Modality Therapy;Cytotoxic T-Lymphocytes;Data;Data Set;Dependence;design;Diagnostic tests;docetaxel;Dose;Eligibility Determination;Endoplasmic Reticulum;endoplasmic reticulum stress;ERBB2 gene;Gene Expression;Gene Expression Profile;Genetically Engineered Mouse;Human;Immune;immune checkpoint;Immune response;Immunocompetent;Immunologics;immunomodulatory therapies;immunoregulation;Immunosuppression;Immunotherapy;in vivo;inhibitor;Intervention;Malignant Breast Neoplasm;Messenger RNA;Metastatic breast cancer;Monitor;Monoclonal Antibodies;mortality;Multicenter Studies;MYC gene;Myeloid-derived suppressor cells;Names;Neoplasm Circulating Cells;nonhuman primate;novel therapeutic intervention;open label;Outcome;Paclitaxel;Pathway interactions;patient derived xenograft model;Patients;Phase;Phase I Clinical Trials;Phase II Clinical Trials;pre-clinical;preclinical study;preclinical trial;Primates;programmed cell death ligand 1;programs;Protein Biosynthesis;Protein Isoforms;Proteins;Randomized;randomized trial;Research;response;response biomarker;Ribonucleases;RNA;RNA Splicing;Safety;sensor;Stress;T cell infiltration;targeted treatment;taxane;Testing;The Cancer Genome Atlas;Therapeutic;Therapeutic Effect;Tissue Microarray;Toxic effect;Toxicology;transcription factor;Translational Research;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor microenvironment;tumor xenograft;tumor-immune system interactions;Up-Regulation;XBP1 gene

PROJECT_TITLE: Targeting Endoplasmic Reticulum Stress Sensor IRE1 to Enhance Chemotherapy Sensitivity in MYC-driven breast cancer


PHR: NARRATIVE  For the fastest and most efficient progress against breast cancer, we need to draw the broadest possible range of ideas and approaches into the fight. SPORE developmental projects allow us to take on high risk research and attract new ideas, so that the most promising can earn support to become larger successful efforts either within the SPORE or with other major funding.

PI_NAMEs: ROSEN, JEFFREY MARK (contact)

PROJECT_TERMS: Advocate;anti-cancer research;Applications Grants;Award;Biology;Breast;Breast Cancer Patient;Collaborations;college;Data;Development;fighting;flexibility;Funding;high risk;Individual;Malignant Breast Neoplasm;Medicine;member;outreach;Pilot Projects;Prevention;Productivity;programs;Publications;Research;Research Personnel;Research Project Grants;Resources;skills;Techniques;Translating;translational cancer research;translational goal;Translational Research

PROJECT_TITLE: Developmental Research Program (DRP)


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics

PI_NAMEs: WELLS, KEVIN DALE (contact)

PROJECT_TERMS: Advisory Committees;Animal Testing;Client;Collaborations;Communication;Communities;Core Facility;data communication;data management;data sharing;Databases;disease model;expectation;experience;Family suidae;Farm;genome editing;Health;Human Genome;Individual;interest;Logistics;meetings;Methods;Mission;Modeling;novel;Process;Production;programs;Reagent;Reporting;Research;Resources;Role;safety assessment;Services;somatic cell gene editing;Standardization;System;Technology;Testing;testing services;tool;United States National Institutes of Health

PROJECT_TITLE: Coordination: Swine Somatic Cell Gene Editing Testing Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-V]