NIH_SPENDING_CATS: Cancer;Dietary Supplements;Digestive Diseases;Lung;Lung Cancer;Nutrition;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

ORG_STATE: MI

PHR: Project Narrative To effectively integrate diet into cancer treatment, there is a critical need to define the molecular mechanisms that control the effects of diet on cancer progression and therapeutic efficacy. Changing the types of lipids that are available in the tumor microenvironment directly impacts cancer cell lipid metabolism, which becomes a major driver of dietary effects on tumor biology. To demonstrate the critical role of lipid metabolism in linking diet to cancer, the proposed research will examine how different dietary interventions impact cancer progression and therapy by altering the balance between saturated versus unsaturated fatty acids within tumors.

PI_NAMEs: LIEN, EVAN CHEN (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Acceleration;anti-cancer;Caloric Restriction;cancer cell;cancer diagnosis;Cancer Model;Cancer Patient;cancer prevention;cancer risk;cancer therapy;cell growth regulation;Cell Physiology;Chemoresistance;chemotherapy;circadian;Clinical Research;clinical translation;Collaborations;Compensation;Consumption;Data;Dependence;design;Diet;diet and cancer;dietary;Dietary Fats;Dietary Intervention;dietary manipulation;dietary restriction;Drug Combinations;Equilibrium;Exhibits;Fasting;Fatty Acid Desaturases;Fatty acid glycerol esters;fatty acid metabolism;Fatty Acids;feeding;Foundations;Future;Gene Expression;Genetic;Goals;Growth;High Fat Diet;Impairment;improved;ketogenic diet;Link;Lipid Biochemistry;lipid metabolism;lipidome;Lipids;Lipoma;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Membrane;Membrane Fluidity;Metabolic;Metabolism;Methods;Molecular;Monounsaturated Fatty Acids;Mus;mutant;Non-Small-Cell Lung Carcinoma;Nutrient;Outcome;Pancreatic Ductal Adenocarcinoma;Pathway interactions;patient prognosis;Patients;pharmacologic;pi bond;Polyunsaturated Fatty Acids;Population;pre-clinical;precision nutrition;Proteins;Recommendation;Regulation;Research;Research Personnel;Resistance;response;Role;Saturated Fatty Acids;Signal Transduction;standard of care;Stearoyl-CoA Desaturase;Stress;Stress Response Signaling;stressor;success;synergism;Testing;Therapeutic;therapeutic target;TP53 gene;translational study;Treatment Efficacy;treatment response;treatment strategy;tumor;Tumor Biology;tumor growth;tumor metabolism;tumor microenvironment;tumor progression;Unsaturated Fatty Acids;Variant;Work

PROJECT_TITLE: Diet-mediated regulation of fatty acid saturation impacts cancer progression and therapy responses.

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-B (O1)]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Child Abuse and Neglect Research;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Social Determinants of Health;Violence Research

ORG_CITY: CHICAGO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: FAMILY MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Adverse conditions such as economic deprivation, complex trauma, and chronic parental stress increase the risk that children may be mistreated and may severely undermine their mental health functioning. Many post-Soviet countries struggle with a legacy of a medicalized approach to mental health care that does not address the social and structural factors that contribute to poor mental health. Advancing the mental health of children in post-Soviet Eurasia requires research and capacity building activities that will strengthen collaborative international and regional community–academic partnerships and build expertise to adapt, integrate, and compare multi-level psychosocial interventions that address the underlying family-level and structural risks and protective factors related to child mental health.

PI_NAMEs: ISMAYILOVA, LEYLA  (contact)

PROGRAM_OFFICER_NAME: CUBILLOS, LEONARDO

PROJECT_TERMS: 14 year old;Address;adverse childhood events;Affect;Age;aged;American;Anxiety;Attention;Azerbaijan;Behavior;Behavioral;Boston;Caregivers;Caring;Chicago;Child;Child Abuse;Child Abuse and Neglect;Child Mental Health;child protection;Child Rearing;Childhood;Chronic;Clinical;cognitive process;Collaborations;Communities;community academic partnership;Complement;Complex;cost;Country;Deinstitutionalization;depressive symptoms;deprivation;Developing Countries;Distress;Early Intervention;Economics;efficacious intervention;emotion regulation;Emotional;Emotions;empowerment;Ensure;Evidence based intervention;experience;Exposure to;Family;family structure;functional outcomes;Gender;Goals;Health;health goals;Health Resources;Human;Human Resources;implementation barriers;improved;Individual;International;Intervention;intervention participants;Interview;Link;low and middle-income countries;lower income families;Measurement;Medial;Mediating;Mediator;Medical;Mental Depression;Mental Health;mental health center;Mental Health Services;Mentors;Methodology;Modeling;Mothers;multidisciplinary;multiphase optimization strategy;National Institute of Mental Health;neglect;operation;Outcome;Parents;Pathology;Pathway interactions;Pediatric Hospitals;peer;Performance;Personal Satisfaction;Politics;post-traumatic symptoms;Poverty;prevent;Prevention;preventive intervention;Problem behavior;programs;protective factors;Provider;psychological distress;psychosocial;Recording of previous events;reduce symptoms;Refugees;Research;Research Project Grants;research study;Resource-limited setting;Resources;Risk;Risk Factors;Role;Savings;scale up;secondary analysis;Series;service gap;service providers;Services;Severities;Short-Term Memory;skills;social;social culture;social factors;Social Processes;Societies;Socioeconomic Status;Strategic Planning;Stress;stress reactivity;stressor;structural determinants;Sum;Symptoms;System;Techniques;Testing;tool;Training;Trauma;trauma exposure;traumatic event;treatment as usual;Treatment outcome;UNICEF;Universities;Violence;War;Washington

PROJECT_TITLE: Optimizing Multi-level Interventions to Improve Child Mental Health in Azerbaijan

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-C (01)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Title: Heterogeneous genetic architecture in lung cancer risk Project Narrative Large-scale genetic analyses of lung cancer have identified numerous genetic variants influencing both the risk of lung cancer and nicotine dependence, the major risk factor for lung cancer. The proposed research capitalizes on existing well-curated phenotype and genotyped repositories of lung cancer with both sporadic and familial cases in Europeans and African Americans and aims to characterize shared and distinct genetic profiles in lung cancer risk in the different subgroups defined according to family history status of lung cancer using machine- learning. The findings could unravel complex genetic structures of lung cancer etiology, with potential implications for improved prevention, screening, and management of lung cancer.

PI_NAMEs: BYUN, JINYOUNG  (contact)

PROGRAM_OFFICER_NAME: CARRICK, DANIELLE M

PROJECT_TERMS: Address;Affect;African American population;African ancestry;Alleles;Biological;Cancer Etiology;cancer risk;Candidate Disease Gene;case control;Characteristics;cigarette smoking;Complex;Data;Development;Disease;Environment;Environmental Exposure;epidemiology study;Etiology;European;European ancestry;Event;Family;Family Cancer History;Family history of;family influence;First Degree Relative;Frequencies;gene interaction;Genes;Genetic;genetic analysis;genetic architecture;Genetic Determinism;genetic epidemiology;genetic risk factor;genetic signature;Genetic Structures;genetic variant;genome wide association study;genomic data;genomic locus;Genotype;Germ Lines;Habits;Health;Health Benefit;Heritability;high risk;improved;Individual;Inflammation;Inherited;insight;Investigation;Joints;Knowledge;large datasets;Link;Lung;Machine Learning;machine learning algorithm;Malignant neoplasm of lung;Maps;Methods;Modeling;Molecular;Nicotine Dependence;novel strategies;Pathway Analysis;Phenotype;phenotypic data;Population;Predisposition;Prevention;Public Health;rare variant;Recording of previous events;repository;Research;Resources;Risk;Risk Factors;Role;screening;Signal Transduction;Smoking;Smoking Behavior;Source;Subgroup;Susceptibility Gene;Trees;Variant

PROJECT_TITLE: Heterogeneous Genetic Architecture in Lung Cancer Risk

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-9 (O2)]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Health Services;Hematology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Telehealth;Wound Healing and Care

ORG_CITY: AMHERST

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: Project Narrative There is an unmet need for a low-cost system that can access tissue perfusion during chronic wound care during telehealth consultations. We will implement and validate a smartphone-based system to characterize functional and structural information about the wound, such as vascular structure and hemoglobin in the vessel’s bloodstream. The technology can lead to faster and more precise measurement of wound healing to optimize medication and therapy interventions.

PI_NAMEs: XU, WENYAO  (contact)

PROGRAM_OFFICER_NAME: LASH, TIFFANI BAILEY

PROJECT_TERMS: absorption;Academia;Address;Adopted;Affect;Algorithms;Ambulatory Care Facilities;American;Amputation;Area;Assessment tool;Biological Factors;Biological Markers;biomedical imaging;Biometry;Blood;Blood Circulation;Blood flow;blood perfusion;Blood Vessels;Caregivers;Cells;Cellular Phone;chronic wound;Clinic;Clinical;clinical practice;Clinical Research;Collaborations;Color;Computer software;Consultations;cost;County;Data;decubitus ulcer;deoxyhemoglobin;design;Development;Devices;diabetic;digital;Disease;empowerment;Engineering;Ensure;Evaluation;evidence base;Excision;Financial Hardship;Focus Groups;General Hospitals;Goals;healing;Health;Health Personnel;Healthcare;Healthcare Systems;Hemoglobin;Home;Hospitalization;Human;Image;imaging biomarker;imaging capabilities;imaging system;Imaging technology;improved;Incidence;Individual;Industry;Infection;innovation;Intervention;Left;Life;Light;Lighting;Machine Learning;machine learning algorithm;Maps;Measurement;Measures;Medical center;mHealth;mobile computing;Mobile Health Application;mobile sensing;Monitor;Morphologic artifacts;mortality;Motion;multidisciplinary;Natural regeneration;Neuropathy;novel;novel marker;Nutrient;Operative Surgical Procedures;Optics;Outcome;Oxygen;Oxyhemoglobin;Participant;Patients;Penetration;Performance;Perfusion;Pharmaceutical Preparations;Polychlorinated Biphenyls;prevent;Process;Quality of life;Recovery;repaired;research clinical testing;Resolution;Scheme;Self Management;sensor;sensor technology;signal processing;Signal Transduction;Skin;Skin Temperature;smart technologies;Societies;spectrograph;Stasis Ulcer;statistical learning;Structure;subcutaneous;System;Systems Development;Techniques;Technology;Technology Assessment;telehealth;theories;Therapeutic Intervention;Time;Tissues;tool;Travel;Treatment Cost;treatment planning;treatment services;trend;Ulcer;United States;usability;Venous;Visit;Visualization;Work;wound;wound care;wound healing;wound treatment

PROJECT_TITLE: mHealth Technologies for Assessing Blood Perfusion in Chronic Wounds

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: PULLMAN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Project Narrative  The proposed studies are of an important area of Lyme disease research that has applicability to understanding infectivity and pathogenesis by Borrelia burgdorferi. The proposed research has relevance to public health because the resulting discoveries have the potential to fundamentally advance the field of B. burgdorferi adaptive gene expression, and may have broad implications for host adaptation systems in other animal and human pathogens. Thus, the findings are ultimately expected to be applicable to the health of human beings.

PI_NAMEs: BANKHEAD, TROY MICHAEL (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Affect;Animals;Area;Binding;Borrelia burgdorferi;ChIP-seq;Chromosomes;Chronic;Clinical;crosslink;Data;Dialysis procedure;disability;DNA;DNA Binding;dosage;Down-Regulation;Electrophoretic Mobility Shift Assay;Environment;enzootic;functional outcomes;Gene Dosage;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic;genetic element;Genetic Transcription;Genomic Segment;Goals;Health;Heart;Human;human pathogen;Impairment;In Vitro;in vivo;Infection;Inflammation;innovation;Intercistronic Region;Joints;Knowledge;Life Cycle Stages;Lyme Disease;Maintenance;Mammals;Membrane;Messenger RNA;Methods;Mission;mutant;Mutate;Mutation Analysis;Nature;new therapeutic target;North America;OspC protein;Outcome;pathogen;Pathogenesis;Peripheral;Phenotype;Plasmids;Play;prevent;Promoter Regions;Proteins;Public Health;Publishing;Quantitative Reverse Transcriptase PCR;Research;Role;System;Testing;Therapeutic;Ticks;Tissues;Transcript;United States National Institutes of Health;vaccine development;Vector-transmitted infectious disease;Work

PROJECT_TITLE: Functional and Mechanistic Studies of the Role of Lp17-encoded Factors in Host Adaptation by the Lyme Disease Spirochete

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: OSWEGO

ORG_DEPT: CHEMISTRY

ORG_NAME: COLLEGE AT OSWEGO

PHR: PROJECT NARRATIVE The aim is to develop effective, safe, and stable formulations to improve thermostability of known vaccine platforms. These novel tools are intended to eliminate/simplify the cold chain logistics and reduce vaccine wastage, making these vaccines equitably accessible worldwide.

PI_NAMEs: MIRJAFARI, ARSALAN  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Academic Research Enhancement Awards;Acceleration;Acids;Adenoviruses;age acceleration;Ammonium;analytical method;Anions;base;Binding;Biological Assay;biomaterial compatibility;Capsid Proteins;Cations;Cessation of life;Characteristics;Chemicals;Circular Dichroism Spectroscopy;climate change;Cold Chains;Community Developments;Complex;cost;cost effective;COVID-19 prevention;COVID-19 vaccine;design;Development;Differential Scanning Calorimetry;Disease Outbreaks;Double Stranded DNA Virus;ds-DNA;economic cost;Environment;epidemic potential;Equity;Exposure to;FDA approved;flexibility;Fluorides;Formulation;Generations;genome integrity;global health;Goals;Grant;Hydration status;Hydrogen Bonding;improved;Inequity;innovation;Institution;Instruction;Interdisciplinary Study;intermolecular interaction;Ions;Life;light scattering;Lipid Bilayers;Lipids;Liquid substance;Logistics;low and middle-income countries;meetings;melting;Mentors;Methods;Modeling;Molecular;Monitor;Morphology;Natural Resources;Nature;novel;nucleic acid stability;Outcome;pandemic disease;particle;pathogen;Pattern;Persons;polyol;poor communities;preservation;prevent;Process;Property;Proteins;Protocols documentation;Quantitative Reverse Transcriptase PCR;rational design;Recovery;Refrigeration;remote communities;Research;Resources;RNA;RNA Viruses;Rural Community;Sampling;Scanning;Series;simulation;Solvents;Source;Structure;sugar;System;Techniques;Technology;Temperature;thermostability;Time;tool;Toxic effect;Transportation;undergraduate student;underrepresented minority student;Universities;Vaccination;vaccine access;vaccine candidate;vaccine distribution;vaccine platform;Vaccines;Variant;Viral;Viral Genome;Viral Proteins;Virus;Water;Woman;Work;X-Ray Crystallography;Yellow fever virus

PROJECT_TITLE: Enhancing Vaccine Thermostability with Natural Deep Eutectic Solvents

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-M (80)]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative There is underrepresentation on the basis of socioeconomic factors of persons participating in science and medicine research careers. This program provides a short but intensive research training program that places underrepresented students in a supportive academic setting and supports their careers.

PI_NAMEs: CLAUDIO, LUZ  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Academic Training;Advisory Committees;Affect;Appointment;Biometry;career;Career Choice;career development;Climacteric;Communities;community based research;Consent;Country;data management;Databases;Dedications;Development;disadvantaged student;Discipline;Education;education research;educational atmosphere;Employment;Enrollment;Ensure;Environment;Environmental Medicine;Epidemiology;Evaluation;Evaluation Research;experience;Faculty;faculty mentor;follow-up;Funding;Genetic;Geography;global health;Goals;Guidelines;Health;health care delivery;health disparity;Health Professional;Human;improved;innovation;Institution;interdisciplinary approach;interest;Leadership;Length;Longterm Follow-up;Medical;medical schools;Medicine;member;Mentors;Minority-Serving Institution;Mission;Molecular Biology;multidisciplinary;National Heart, Lung, and Blood Institute;National Institute of Environmental Health Sciences;Occupational Health;Outcome;outreach;Paper;Participant;peer coaching;people of color;Persons;Policies;population health;Positioning Attribute;Private Sector;Productivity;professional students;programs;psychologic;Public Health;Publishing;Recommendation;Research;Research Training;Science;Scientist;skills;social;socioeconomic disadvantage;Socioeconomic Factors;socioeconomics;student participation;Student Selections;Students;success;System;Talents;Time;Training;Training Activity;Training Programs;Underrepresented Students;United States National Institutes of Health;vulnerable community;Work;Writing

PROJECT_TITLE: Short-term Research Education to Increase Diversity

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-K (O1)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases

ORG_CITY: CALDWELL

ORG_NAME: COLLEGE OF IDAHO, INC.

ORG_STATE: ID

PHR: PROJECT NARRATIVE The work described in this proposal will facilitate the development of bioinspired tandem g-C3N4/peroxidase systems for antibacterial, anti-biofilm and anti-quorum sensing applications. Complementary cell toxicity experiments will further establish the utility of these systems as novel microbiocidal agents. Moreover, the interdisciplinary nature of the described project will allow it to serve as a unique, integrated, high impact educational experience in which undergraduate students from the College of Idaho and Boise State University explore the design, fabrication and validation of functional materials for biomedical applications.

PI_NAMEs: THURSTON, JOHN HENRY (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Advanced Development;Affect;Aliquot;Anions;Anti-Bacterial Agents;antimicrobial;Bacterial Infections;Basic Science;Biological;Biological Assay;Breathing;Candida albicans;Carbon;catalyst;cell type;Cells;cellular targeting;chronic infection;chronic wound;combat;Communication;cytotoxic;cytotoxicity;Data;design;Development;Devices;disability;Education;Elements;Enzymes;Event;Exhibits;experience;experimental study;fabrication;Fibroblasts;Generations;Genus staphylococcus;Goals;halogenation;Halogens;healing;Health;Healthcare Industry;HOI;Human;Hydrogen Peroxide;Idaho;Immune response;improved;In Vitro;Infection;Interdisciplinary Study;Interruption;keratinocyte;Knowledge;Life;Mammalian Cell;Medical;Medical Care Costs;Metals;Methicillin Resistance;microbial;Microbial Biofilms;microorganism;Mission;Molecular;Molecular Structure;Molecular Target;Nature;neutrophil;novel;novel strategies;Organism;Oxygen;Pathogenicity;Peroxidases;Population;prevent;Process;Production;Pseudomonas aeruginosa;quorum sensing;Reactive Oxygen Species;recurrent infection;Reporting;Research Personnel;Respiratory Burst;response;Sampling;screening;Semiconductors;Series;Signal Transduction;Source;Streptococcus pyogenes;Superoxides;Support System;System;Technology;Toxic effect;Training;Translations;undergraduate student;United States;United States National Institutes of Health;Universities;university student;Validation;Visible Radiation;Work

PROJECT_TITLE: Development of bioinspired tandem semiconductor/peroxidase systems for microbiocidal applications.


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Brain Disorders;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Social Determinants of Health;Teenage Pregnancy;Violence Against Women;Violence Research;Women's Health Research;Youth Violence

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project narrative Cash transfer programs to alleviate poverty have been shown to reduce depression in adults, however, information on how these programs may impact depression in adolescents may vary based on factors such as household poverty or exposure to violence. In this study we will examine these questions using an existing database of a large, cohort of over 2,000 adolescent girls in rural South Africa followed for over 8 years during a critical time in development from early adolescence into early adulthood to determine the impact of two different cash transfer programs and how such program effect the relationship between childhood exposure to adversity and its relationship to depression. Given that millions of households in the African region receive cash transfers as part of government social protection programs, this study informs important gaps in our understanding of how CTs may be leveraged to buffer childhood adversities and improve child and adolescent mental health.

PI_NAMEs: PETTIFOR, AUDREY  (contact)

PROGRAM_OFFICER_NAME: CAMPBELL-ROSEN, HOLLY RENEE

PROJECT_TERMS: Adolescence;Adolescent;adolescent mental health;Adult;adverse childhood events;Affect;Africa South of the Sahara;African;Age;Behavioral;Biological;Biological Markers;Buffers;child depression;Child Mental Health;Child Support;Childhood;childhood adversity;Cognitive;cohort;Communities;Community Surveys;community violence;critical developmental period;Data;Data Set;Data Sources;Databases;Development;early adolescence;Early Intervention;Education;emerging adult;Emotional;examination questions;executive function;experience;Exposure to;Family Violence;Female Adolescents;Fostering;girls;Government;Grant;Health Promotion;Heterogeneity;Household;improved;Interruption;Intervention;intervention effect;intimate partner violence;Link;Longitudinal cohort;longitudinal dataset;low and middle-income countries;Measures;Mediating;Mediation;Mediator;Mental Depression;Mental Health;Mental health promotion;Modeling;multidisciplinary;Outcome;Pathway interactions;Personal Satisfaction;Population;Poverty;poverty alleviation;Pregnancy;Pregnancy in Adolescence;Process;programs;psychosocial;Randomized;Research;resilience;Rural Health;rural South Africa;self esteem;social;Social outcome;Social Protection;sociodemographics;South Africa;South African;Stress;surveillance data;Testing;Time;United States National Institutes of Health;Violence;violence exposure;Vulnerable Populations;Women's cohort;Work;young woman;Youth

PROJECT_TITLE: Pathways to protection: understanding how cash transfers can protect the mental health of rural South African adolescents growing up in adversity


NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative This project aims to unlock the potential of combining wearable mobile recording devices, such as smartphones with continuous audio-visual, accelerometry, GPS, subjective report, autonomic physiology, and wearable eye tracking recordings, with precisely synchronized intracranial neural recordings during real-world behaviors. Autobiographical memory (AM) formation is a critical human behavior that has been difficult to study with traditional neuroimaging methods. Thus the proposed project aims to develop a smartphone-based recording application (CAPTURE app; R61 phase) synchronized with wearables and invasive neural recordings during real-world behaviors like autobiographical memory encoding (R33 phase).

PI_NAMEs: INMAN, CORY SHIELDS (contact)

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: Accelerometer;Address;Alzheimer's Disease;analytical method;Attention;Autobiography;Behavior;Behavioral;Brain;Cellular Phone;Characteristics;Chronic;cloud storage;Cognition;Cognitive;cognitive process;Complex;Data;Data Security;Data Set;Data Storage and Retrieval;data streams;data structure;Decision Making;design;Devices;Disease;Electroencephalography;Electrophysiology (science);Emotional;Emotions;Environment;Epilepsy;Episodic memory;Ethics;experience;experimental study;flexibility;Foundations;Functional Magnetic Resonance Imaging;Goals;Human;Implant;improved;Individual;insight;Laboratories;Life;Life Experience;Location;long term memory;Memory;Memory Disorders;memory encoding;memory retrieval;Methodology;Methods;millisecond;multimodal data;Museums;Nervous System Disorder;neural;neural correlate;neural implant;neural stimulation;neuroimaging;neuromechanism;neuroregulation;Neurosciences;next generation;novel;Participant;Performance;Persons;Phase;Physiology;Privacy;Process;Psychophysiology;Reporting;Research;Research Project Grants;research study;Resolution;response;Retrieval;Secure;sensor;smart watch;smartphone application;Social Interaction;Stream;System;Techniques;Temporal Lobe;Testing;Therapeutic;Time;tool;Translating;Universities;Utah;visual tracking;wearable device;wearable sensor technology;Weight;wireless

PROJECT_TITLE: Capturing Autobiographical memory formation in People moving Through real-world spaces Using synchronized wearables and intracranial Recordings of EEG

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-E (01)]


ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Our long-term goal is to identify mechanisms for maternal lipid regulation of offspring development of allergic responses. As a step towards our long-term goal, our central hypothesis is that increases in DHET levels in allergic mothers regulate the development of offspring numbers of CD11b+CD11c+ DCs, lung microbiome dysbiosis, and responses to allergen early in life. Successful completion of these studies will have a significant impact on our understanding of mechanisms of maternal lipid regulation of offspring DCs during development of allergies and the design of future clinical studies that may lead to novel interventions to significantly impact risk for allergic disease.

PI_NAMEs: COOK-MILLS, JOAN M (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Acids;Address;Allergens;Allergic;Allergic Disease;Allergic inflammation;allergic response;Animal Model;Animals;Asthma;atopy;Bacteria;Bone Development;Bone Marrow;Cell Count;Cell Differentiation process;Cell Physiology;Child;Clinical Research;Communities;curative treatments;Data;Dendritic Cells;design;Development;Discipline of Nursing;dysbiosis;eicosanoid metabolism;Eicosanoids;Enzymes;Epithelium;Epoxide hydrolase;Extrinsic asthma;fetal;Fetal Liver;Fetus;Future;Goals;Hematopoiesis;Human;Human Milk;Hydrolase;Hypersensitivity;IgE;in utero;In Vitro;indexing;Infant;Inflammatory;Interleukin-4;Intervention;IRF4 gene;ITGAM gene;ITGAX gene;Life;lipidomics;Lipids;Lung;lung development;lung microbiome;lung microbiota;Mediating;Mediator;microbiota;microbiota composition;Milk;Modeling;monocyte;Mothers;mouse model;Mus;Neonatal;neonate;novel;offspring;Pathway interactions;Patients;Placenta;Plasma;Prevalence;pulmonary function;pup;Recording of previous events;Regulation;response;Risk;Risk Factors;Testing;transmission process;Umbilical Cord Blood;Wheezing

PROJECT_TITLE: Development of allergy in offspring is enhanced by maternal eicosanoids and lung microbiota composition dysbiosis.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-B (57)]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Rural Health;Social Determinants of Health;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Chronic neuropathic pain impacts up to 69% of adults with spinal cord injury (SCI) and treatment options are limited, primarily focused on pain medications with insufficient benefits and significant risks for addiction and adverse effects. Of the available mind and body approaches, Qigong is the most accessible for adults with SCI with evidence for effectiveness in reducing pain, but there is not enough evidence to make recommendations for adults with SCI, especially those with health disparities, prompting our proposal to investigate the feasibility of remotely delivered Qigong vs pain management with daily 2-minute surveys for neuropathic pain relief in populations with SCI and with health disparities. The outcomes of this study will facilitate a rigorous structure to design larger effectiveness studies and facilitate a clear pathway for researchers to investigate Qigong vs active comparison groups and other mind-body approaches for whole-person health in adults with chronic diseases and neurological disorders.

PI_NAMEs: VAN DE WINCKEL, ANN L (contact)

PROGRAM_OFFICER_NAME: MUDD, LANAY MARIE

PROJECT_TERMS: acceptability and feasibility;Activities of Daily Living;addiction;Address;Adherence;Adult;Adverse effects;Age;Analgesics;Behavioral;Biometry;Chronic;Chronic Disease;chronic neuropathic pain;Clinical Trials;Communities;community organizations;comparison group;Complementary therapies;Control Groups;course introduction;Data;Data Collection;design;Distress;Effectiveness;effectiveness clinical trial;effectiveness study;effectiveness trial;Elements;Enrollment;Event;experimental group;Feasibility Studies;Feeling;Focus Groups;follow up assessment;follow-up;Health Insurance Portability and Accountability Act;hispanic community;Hispanic Populations;Home;Integrative Therapy;Internet;Intervention;Interview;Life;Measures;meetings;Methods;Mind-Body Intervention;mind/body;Minnesota;Minority Groups;Mission;Movement;multidisciplinary;National Center for Complementary and Integrative Health;Nervous System Disorder;Not Hispanic or Latino;older adult;Outcome;Outcome Measure;Outcome Study;Pain;Pain intensity;Pain management;pain reduction;pain relief;Pain Research;painful neuropathy;Paraplegia;Participant;Pathway interactions;Pharmaceutical Preparations;Phase;Population Heterogeneity;Positioning Attribute;programs;Protocols documentation;Qi Gong;Quadriplegia;Qualifying;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;recruit;remote delivery;Research;Research Design;Research Personnel;Research Priority;Risk;Rural;rural area;satisfaction;sociodemographics;socioeconomics;South Texas;Specific qualifier value;Spinal cord injury;structural determinants;Structure;Surveys;Time;trial design;underserved area;United States Department of Veterans Affairs;Veterans;whole health;Woman

PROJECT_TITLE: HAPPINESS: cHAnging the Perceived Pain INtensity in populations with Spinal cord injury and with health disparities

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 MH (05)]


NIH_SPENDING_CATS: Anxiety Disorders;Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Complementary and Integrative Health;Epilepsy;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative Existing studies of human behavior and cognition typically must choose between being ecologically valid or data-rich given that current and most often-used neuroimaging methods do not allow for simultaneous neuronal and peripheral biomarker recordings during free movement. The proposed project will develop a first- of-its-kind research platform for recording brain, biochemical, and biophysical activity via advanced wearables to enable the investigation of naturalistic human behavior. The technologies developed will be useful for numerous future studies, and potentially will open an entirely new area of research within the fields of basic, cognitive, and clinical neuroscience.

PI_NAMEs: SUTHANA, NANTHIA A (contact)

PROJECT_TERMS: Acute;Amygdaloid structure;application programming interface;approach/avoidance behavior;Area;Augmented Reality;Behavior;Binge eating disorder;Biochemical;Biochemical Markers;Biological Markers;Biophysical Process;Biophysics;Brain;Brain region;Chemicals;Chronic;Clinical;Cognition;Cognitive;Collaborations;Computer software;Custom;Data;design;Devices;Electrodes;Electroencephalography;empowerment;Environment;Epilepsy;Epinephrine;Equipment;Eye Movements;Future;Galvanic Skin Response;Healthcare Systems;Heart Rate;heart rate monitor;heart rate variability;Hippocampus;Hospitals;Human;Hydrocortisone;Implant;Implanted Electrodes;interdisciplinary collaboration;Investigation;Laboratories;light weight;Los Angeles;Mental disorders;Methods;microchip;Microfluidics;miniaturize;Movement;multimodality;neural;neural implant;neuroimaging;Neurons;neurophysiology;neuropsychiatry;neuroregulation;Neurosciences;next generation;novel;Nucleus Accumbens;Outcome;Participant;Patients;Peripheral;Phase;Post-Traumatic Stress Disorders;Prefrontal Cortex;programs;Research;Research Personnel;response;Scientist;sensor;Signal Transduction;smart watch;Stimulus;System;Technology;Therapeutic;Time;United States Department of Veterans Affairs;Universities;visual tracking;Walking;way finding;wearable device;wearable platform;wireless

PROJECT_TITLE: Synchronized neuronal and peripheral biomarker recordings in freely moving humans


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Dissemination and Implementation Research;Genetic Testing;Genetics;Health Services;Prevention;Primary Health Care

ORG_CITY: DANVILLE

ORG_NAME: GEISINGER CLINIC

ORG_STATE: PA

PHR: PROJECT NARRATIVE Individuals with a genetic disorder of high cholesterol called familial hypercholesterolemia (FH) can significantly reduce their high risk of premature atherosclerotic cardiovascular disease (ASCVD) if they are identified early in life and provided treatment to lower their cholesterol. Few individuals with FH are being identified and treated because we do not understand how best to implement screening programs and measure their cost. This study will answer important questions about generalizability, cost, and sustainability of implementation strategies to improve FH screening and identification through targeted strategies and lowering risk for ASCVD in those affected.

PI_NAMEs: MORALES REYES, ANA  (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: acceptability and feasibility;Address;Adopted;Adoption;advocacy organizations;Affect;Age;Atherosclerosis;atherosclerosis risk;Cardiovascular system;care outcomes;Caring;cascade genetic testing;Cessation of life;chatbot;Cholesterol;Clinical;Communication;coronary event;cost;Cost Analysis;cost estimate;Country;Data;Decision Making;Diagnosis;Early identification;Economic Models;Electronic Health Record;European;Evidence based intervention;Familial Hypercholesterolemia;Family;Feedback;First Degree Relative;Genetic;Genetic Diseases;genetic testing;genetic variant;Goals;health care settings;Health system;high risk;implementation cost;implementation efforts;implementation outcomes;implementation science;implementation strategy;improved;Income;Individual;Institution;Interview;Leadership;Life;Lipids;Measures;medical specialties;men;Methods;Modeling;Morbidity - disease rate;mortality;Myocardial Infarction;novel;Outcome;patient population;Patients;Performance;Persons;Phase;Population;pragmatic trial;premature;Prevention program;Primary Care;primary care clinician;primary care setting;primary outcome;Process;programs;promoter;Reporting;Risk;screening;screening program;success;Surveys;sustainability framework;Technology;Testing;testing uptake;text searching;tool;Training;uptake;user-friendly;Woman

PROJECT_TITLE: Identification Methods, Patient Activation, and Cascade Testing for FH: IMPACT-FH

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Endometriosis;Genetics;Human Genome;Pain Research;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: NARRATIVE Endometriosis is an understudied and underfunded complex disease that significantly contributes to infertility and pelvic pain in women. Available treatments are limited because the molecular mechanisms of endometriosis are not well understood. Using clinically relevant human samples, and cellular and mouse models, we propose to study the roles of GATA transcription factors in endometriosis that will lead to better understanding of the disease and future development of novel therapeutics for endometriosis.

PI_NAMEs: BULUN, SERDAR E.;CHAKRAVARTI, DEBABRATA  (contact);PARKER, JAMES BRANDON

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: 3-Dimensional;Address;Affect;Age;Area;Biological Assay;Cell model;Cells;Chromatin;Chronic;chronic pelvic pain;Clinical;clinically relevant;Complex;Coupled;Data;Decidual Cell Reactions;Defect;Development;Disease;DNA Methylation;Emotional;Endometrial;Endometrial Stromal Cell;endometriosis;Endometrium;Enhancers;Environment;Epigenetic Process;epigenome;epigenomics;Epithelial Cells;Epithelium;eutopic endometrium;experience;Family;Female Genital Diseases;Financial Hardship;Functional disorder;Future;GATA2 deficiency;GATA2 transcription factor;GATA4 gene;GATA6 transcription factor;Gene Expression;Genetic Transcription;genome-wide analysis;histone modification;Human;in vivo;Infertility;Inflammation;Inflammatory;innovation;Island;Knowledge;Modeling;Molecular;mouse model;Mus;Mutation;natural Blastocyst Implantation;novel;novel therapeutics;Organ;Outcome;overexpression;Pathologic;Patients;Pelvic Pain;Pelvis;Phenotype;Physiological;precision medicine;Predictive Value;Process;Progesterone;promoter;reproductive;Research;Resistance;Retrograde Menstruation;Role;Sampling;social;stem;Steroids;Stromal Cells;Testing;Therapeutic Intervention;Tissues;transcription factor;transcriptome;transcriptomics;Travel;Woman;Work;Xenograft procedure

PROJECT_TITLE: Roles of GATA Transcription Factors in Endometriosis

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease;Microbiome;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE There exist vast gaps of knowledge in the molecular basis that drives age-unrelated intestinal senescence and its pathological consequences. In this project, we will investigate the interplays between gut epithelial cells and microbiota in the regulation of colonic senescence. Specifically, we will prove the concept that decline of key host enzymes and gut bacterial dysbiosis together induce epithelial acetyl-CoA deficiency that triggers rapid colonic ageing, demonstrate the connection between colonic senescence and colitis, and explore colonic senescence as a therapeutic target for the treatment of inflammatory bowel disease.

PI_NAMEs: LI, YAN CHUN  (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Acetate-CoA Ligase;Acetates;Acetyl Coenzyme A;Acetylation;Age;age related;Age related pathologies;Aging;Animals;ATP Citrate (pro-S)-Lyase;Cell Aging;Cell Cycle Arrest;Cells;Cessation of life;chemokine;Chronic;Colitis;Colon;cytokine;Data;Development;Disease;Disease Management;DNA Damage;DNA Repair;Down-Regulation;dysbiosis;Electron Transport;Enzymes;Epithelial Cells;Epithelium;Fibrosis;Functional disorder;gastrointestinal epithelium;Gastrointestinal tract structure;Goals;Growth Factor;gut dysbiosis;gut microbes;Homeostasis;Human;Immune;immune clearance;Immunologic Surveillance;Impairment;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Injury;insight;Intestines;Investigation;Knowledge;Link;Lysine;Malignant Neoplasms;Metabolic;Metabolic Control;Microbe;microbiota;microorganism interaction;Mitochondria;Molecular;Mucositis;Mucous Membrane;murine colitis;Mus;new therapeutic target;novel;novel marker;Nuclear;Oxidative Stress;Pathogenesis;Pathogenicity;Pathologic;Patients;Peptide Hydrolases;pharmacologic;Play;premature;prevent;Production;Proteins;recruit;Regulation;Role;senescence;senescence associated secretory phenotype;senescent cell;Site;stem cell niche;stem cells;systemic inflammatory response;Testing;therapeutic target;Time;Tissues;TP53 gene;tumor;Virulence Factors

PROJECT_TITLE: Metabolic Regulation of Colonic Senescence and Pathological Implications: Epithelial and Microbial Interactions

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: NS

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: Project Narrative Neurochemicals represent the fundamental signal carriers within the brain, whether it be through the rapid movement of ions across cell membranes when neurons spike, or through the cellular exchange of neurotransmitters, monitoring brain neurochemistry continues to lead us toward better understanding of how neural circuits function, and towards pharmaceuticals and treatments that improve the quality of people's lives. Electrochemical sensors are the most popular devices to measure brain neurochemistry, however they are generally lacking the capability for long-term studies for chronic implant applications, are not very selective, and are subject to fouling and drift. Adoption of hydrodynamic electrochemical sensors by leveraging silicon microfabrication technology to integrate sophisticated microfluidics allow for sensors that are capable of calibration and regeneration in-situ and introduce novel modes of measurement to study the brain.

PI_NAMEs: BRENDEN, CHRISTOPHER KENJI (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TITLE: Integrated microfluidic electrochemical neural probe with monolithic sampling, in-situ calibration, and online detection of neurochemicals for increased long-term performance


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Disability Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

PHR: Project Narrative Motor development plays a crucial role in the acquisition of social communication skills, cognition, and language, and motor impairments detrimentally affect downstream development. Many neurodevelopmental disorders describe motor impairments as an early comorbid symptom; however, current standardized assessments of motor function fail to clearly characteize these early motor impairments. This longitudinal study will utilize quantitative measures to objectively characterize the earliest manifestation of motor impairments in infants at high risk for autism and other neurodevelopmental disorders and elucidate the mechanistic relationship of these impairments to symptoms of autism and other adverse developmental outcomes with the goal to improve early identification and inform targeted interventions.

PI_NAMEs: WILSON, RUJUTA BHATT (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Address;advanced analytics;Affect;Age Months;associated symptom;Attention deficit hyperactivity disorder;autism spectrum disorder;autism symptoms;Automobile Driving;Behavior;Behavior Disorders;Behavioral;Benchmarking;Biological Markers;Biometry;career development;Child;child services;Clinical;clinical application;Clinical Markers;Clinical Research;clinical risk;Clinical stratification;Cognition;cognitive process;Complex;Conduct Clinical Trials;Data;Data Set;Dedications;design;Development;Developmental Delay Disorders;Diagnosis;Diagnostic;Disease;Early identification;Education;Engineering;Environment;Evaluation;Frequencies;Genetic;Goals;Health;high risk;high risk infant;Impairment;improved;infancy;Infant;innovation;Intellectual functioning disability;Intervention;Intervention Studies;K-Series Research Career Programs;Knowledge;Knowledge acquisition;Language;Language Development;language impairment;Leg;Life;Life Experience;Locomotion;Longitudinal Studies;Machine Learning;Measurement;Measures;Mentors;Mentorship;Methods;Modeling;Monitor;Motor;motor impairment;Motor Manifestations;Motor Skills;Movement;multidimensional data;National Institute of Child Health and Human Development;Nervous System Disorder;Neurodevelopmental Disorder;neuroimaging;Neurologist;Neurology;Normal Range;novel;Outcome;Outcome Measure;outcome prediction;Pattern;Perinatal Brain Injury;Phenotype;Play;Population;predictive modeling;Prevalence;Psychiatrist;Psychiatry;Psychology;Research;Research Design;Research Priority;Resources;Risk;Risk Marker;risk prediction;risk stratification;Role;Scientist;screening;sensor;Sensory;Severities;Siblings;signal processing;skill acquisition;skills;social communication;social engagement;Space Perception;Standardization;standardize measure;Statistical Methods;statistics;study population;Symptoms;Syndrome;Techniques;Theoretical model;tool;Training;Translating;Visual Motor Coordinations;wearable sensor technology

PROJECT_TITLE: Quantification of Infant Motor Development to Predict Risk for Neurodevelopmental Disorders

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Biobehavioral and Behavioral Sciences Study Section[CHHD-H]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Genetic Testing;Genetics;Health Services;Human Genome;Mental Health;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Telehealth;Women's Health Research

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: We will assess the merits of a supportive behavioral intervention to be delivered after genetic counseling, testing, and BRCA+ carrier identification in mothers raising adolescent and young adult (AYA) children. The work is directly in line with a Healthy People 2020 goal of ‘improving health and preventing harm through valid and useful genomic tools in clinical and public health practices,’ especially as the US strives to achieve its public health goal of ‘increasing the proportion of women with a family history of breast and/or ovarian cancer who receive genetic counseling.’

PI_NAMEs: PESHKIN, BETH N;TERCYAK, KENNETH  (contact)

PROGRAM_OFFICER_NAME: FERRER, REBECCA

PROJECT_TERMS: 2 arm randomized control trial;Address;Adolescent and Young Adult;Adoption;Adult;Adult Children;Aftercare;Age;Ally;anti-cancer research;Anxiety;Area;arm;Awareness;Behavior Therapy;Behavioral;Blood;brca gene;BRCA mutations;Breast;Cancer Control;cancer genetics;cancer prevention;cancer risk;Caregivers;Caring;Child;Child Rearing;Clinical;Cognitive;Collaborations;Communication;communication aid;communication behavior;Communities;Complex;Conflict (Psychology);coping;Coping Skills;Counseling;Critical Care;Data;Daughter;Decision Making;Disclosure;Distress;Educational process of instructing;efficacy testing;Emotional;evidence base;experience;Face;Family;Family history of;Feeling;Female Adolescents;Future;Gene Mutation;Genes;Genetic;Genetic Counseling;genetic counselor;genetic information;genetic testing;genomic tools;Goals;Guilt;Health;health goals;Healthy People 2020;Hereditary Malignant Neoplasm;high risk;improved;Inherited;intergenerational;Intervention;kindred;Knowledge;lifetime risk;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Manuals;Mediating;Medical;member;Mental Depression;Modeling;Monitor;Mothers;mutation carrier;Notification;Oncology;Operative Surgical Procedures;Outcome;Parents;Participant;Patients;peer;peer coaching;peer support;Pilot Projects;Population Genetics;Predisposition;preference;prevent;Prevention;Proliferating;Protocols documentation;psychological distress;psychosocial;Psychosocial Assessment and Care;Public Health;Public Health Practice;Randomized;randomized trial;recruit;Reporting;Resources;response;Risk;Risk Reduction;screening;Self Efficacy;Self Management;Service delivery model;Siblings;Site;skills;social;Son;standard care;Stress;Structure;telephone coaching;telephone session;Test Result;Testing;Thinking;Time;Training;treatment as usual;Uncertainty;Well in self;Woman;Work

PROJECT_TITLE: Improving Genetic Counseling for BRCA+ Mothers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-SEIR-B(80)]


NIH_SPENDING_CATS: Clinical Research;Genetics;Lung;Pulmonary Fibrosis;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative  Idiopathic pulmonary fibrosis (IPF) is a devastating disease of relentless scarring in the lungs, which leads to severe debilitation and eventually respiratory failure and death. The cause of IPF is not known, and there are few treatments available. This project explores one of the underlying mechanisms of IPF, and how manipulating a cellular stress response pathway might enable progenitor cells to repair the lung, rather than promote scar tissue.

PI_NAMEs: AUYEUNG, VINCENT CHURK-MAN (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Alleles;alveolar epithelium;Apoptosis;Binding;Biological;Biological Availability;Biology;Bleomycin;career;Cell Aging;Cell Count;Cell Death;Cell Physiology;Cells;Cellular Stress;Cessation of life;Chemicals;Cicatrix;Collaborations;Data;Developmental Biology;Diagnosis;Disease;DNA Damage;Endoplasmic Reticulum;endoplasmic reticulum stress;Endoribonucleases;Environment;Environmental Exposure;Epithelial Cells;epithelial injury;epithelial stem cell;Epithelium;Equilibrium;Equipment;Etiology;Event;Family;Family member;Fibrosis;fibrotic lung;Flow Cytometry;Functional disorder;Gene Expression;Gene Expression Profile;gene repression;Genes;Genetic;Genetic Models;genetic risk factor;genetic signature;Histologic;Human;Hyperactivity;idiopathic pulmonary fibrosis;in vitro Model;indium-bleomycin;innovation;Integrins;International;interstitial;K-Series Research Career Programs;kinase inhibitor;Knock-out;Laboratories;Link;Lung;lung development;Lung Diseases;lung injury;lung regeneration;lung repair;Mediating;Mediator;Membrane;Mentors;Mentorship;Messenger RNA;MicroRNAs;Mission;Modeling;mouse model;Mus;mutant;Outcome;overexpression;Pathogenicity;Pathologic;Pathway interactions;Patients;Phosphotransferases;Physicians;Physiological;Population;premature;Productivity;Profibrotic signal;Progressive Disease;protein folding;protein misfolding;Proteins;Pulmonary Fibrosis;Records;regeneration potential;regenerative biology;repaired;Research;research clinical testing;Respiratory Failure;response;Ribonucleases;RNA Splicing;Scientist;secretory protein;Seminal;senescence;senescence associated secretory phenotype;Signal Transduction;single cell sequencing;skills;stem cells;Stress;symposium;Telomere Shortening;Testing;Tissues;Training;transcription factor;Transforming Growth Factor beta;Translations;XBP1 gene

PROJECT_TITLE: IRE1α mediated dysregulation of the pulmonary epithelium in lung fibrosis

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Radiation Oncology;Regenerative Medicine

ORG_CITY: ROCHESTER

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Cellular Plasticity in Salivary Gland Regeneration Although radiation damage is often considered irreversible, we have found that irradiated salivary glands have regenerative potential. Furthermore, we demonstrated that under severe conditions, salivary gland cells undergo lineage conversion to replace lost cells. To explore whether this process can be harnessed as a therapeutic modality for treating patients living with permanent xerostomia, we will focus on characterizing the mechanism and regulation of cellular plasticity in salivary gland cells.

PI_NAMEs: LARSEN, MELINDA ;OVITT, CATHERINE  (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Acinar Cell;Adult;Affect;Automobile Driving;Cancer Patient;Cancer Survivor;Cell Cycle;Cell Differentiation process;cell growth regulation;Cell Lineage;cell regeneration;Cell Separation;Cell Transplantation;cell type;Cells;Chronic;Clinical;Data;Development;Duct (organ) structure;Ductal Epithelial Cell;Embryo;Exhibits;Exogenous Factors;experimental study;Fibrosis;functional restoration;Genetic Transcription;Gland;Head and Neck Cancer;head and neck cancer patient;Heritability;Human;improved;In Vitro;in vivo;Inflammation;Inflammatory;injured;Injury;injury and repair;insight;Intervention;Investigation;Ionizing radiation;irradiation;Knowledge;Label;Laboratories;Ligation;Modality;Modeling;Molecular;Mus;Natural regeneration;Organ;Organism;paracrine;Pathway interactions;Patients;Pharmaceutical Preparations;Play;Population;Population Heterogeneity;prevent;Process;progenitor;programs;Proliferating;Property;Quality of life;Radiation;Radiation induced damage;radiation mitigation;Radiation therapy;regeneration potential;regenerative;regenerative approach;Regenerative capacity;regenerative cell;repaired;Reporting;Resolution;response;response to injury;Role;Salivary Glands;senescence;senolytics;single cell sequencing;single-cell RNA sequencing;success;Testing;Therapeutic;tissue regeneration;tissue repair;Tissues;trait;Xerostomia

PROJECT_TITLE: Cellular plasticity in salivary gland regeneration.


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE Early life adversity (ELA) is of critical concern for early prevention and intervention efforts, as it predicts risk for mental and physical health concerns that cause significant economic burden, and risk for higher acuity and chronicity with respect to disease course. The current proposal seeks to apply advanced, innovative analyses of electroencephalogram (EEG) reward and threat processing risk markers in an early childhood sample to identify the proximal impact of early life adversity. By probing the impact of ELA on electrocortical risk markers for later psychopathology, mechanisms through which ELA may increase risk for adverse psychiatric outcomes may be further identified in future studies, which has implications for prevention and intervention efforts for ELA-exposed youth.

PI_NAMEs: GRANROS, MARIA  (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: 6 year old;Address;Adolescence;Adolescent;Adult;Affective;Assessment tool;Attenuated;Buffers;career;caregiving;Chicago;Child;Child Rearing;Childhood;Chronic;Clinical;Cognitive;Collection;Communities;cost;cost effective;critical period;deprivation;Detection;Development;Dimensions;Disease;early childhood;early life adversity;Economic Burden;Electroencephalography;emotional neglect;Ensure;Environment;Event-Related Potentials;Exhibits;experience;Exposure to;Frequencies;Functional disorder;Future;Goals;Health;high risk;human capital;indexing;Individual;inner city;innovation;Intervention;Interview;Investigation;Knowledge;Link;maternal caregiving;Measures;Mental Depression;Mental disorders;Mental Health;Methods;Modeling;Morbidity - disease rate;Mothers;multimodality;Nature;neglect;Neighborhoods;neural;neural circuit;neuroimaging;neurophysiology;novel;Outcome;outcome disparities;Pathway interactions;Patient Self-Report;Pattern;pediatric trauma;Personal Satisfaction;physical abuse;physical conditioning;Prevention;preventive intervention;Process;Psychopathology;Recording of previous events;recruit;Research;Research Personnel;response;reward processing;Rewards;Risk;Risk Marker;risk prediction;Role;Safety;Sample Size;Sampling;Severities;Statistical Methods;Stimulus;Structure;suicidal risk;Symptoms;System;Techniques;Testing;Time;tool;Training;Work;Youth

PROJECT_TITLE: Investigating the Proximal Impact of Early Life Adversity on Neural Reward and Threat Reactivity in Early Childhood

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F01A-F(20)]


NIH_SPENDING_CATS: Aging;Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: RELEVANCE Emotion dysregulation is common across populations, may be particularly elevated in those with autism spectrum disorder, and has a significant negative impact on daily life across the lifespan. Building on the prior successful development of the Emotion Dysregulation Inventory (EDI), this study will refine and validate new early childhood and self-report versions of the EDI, and ensure their utility across populations through evaluation of their psychometrics in autism, other intellectual and developmental disorders, and general samples. Finally, the EDI will be linked to specific neural features underlying emotion dysregulation in order to support experimental therapeutics approaches to clinical trials and to enhance the translational value of this research.

PI_NAMEs: MAZEFSKY, CARLA A (contact)

PROJECT_TERMS: 17 year old;5 year old;Address;Admission activity;Adolescent;adolescent with autism spectrum disorder;Adult;adult with autism spectrum disorder;Age;Aggressive behavior;autism spectrum disorder;autistic children;Awareness;Brain;Calibration;Caregivers;Censuses;Characteristics;Child;Clinical;Clinical Trials;clinically significant;Cognitive;cognitive ability;cognitive interview;Collection;Communities;Comprehension;cost;Country;Crisis Intervention;critical period;Data;Data Reporting;Development;Developmental Delay Disorders;developmental disease;Diagnosis;Diagnostic;dysphoria;early childhood;effective therapy;emotion dysregulation;Emotional;Emotions;Enrollment;Ensure;Equipment and supply inventories;Evaluation;Evidence based intervention;experience;flexibility;follow up assessment;Frustration;functional near infrared spectroscopy;Funding;Future;Gender;Generations;Impaired cognition;Impairment;improved;individuals with autism spectrum disorder;Information Systems;Inpatients;Intellectual functioning disability;Intervention;Investigational Therapies;Lateral;Life;life span;Link;Longitudinal Studies;Measurement;Measures;Mental disorders;Methods;Monitor;Morbidity - disease rate;neural;neuroimaging;non-verbal;Nursery Schools;Outcome;Outpatients;Painless;Parents;Participant;Patient Outcomes Assessments;Patient Self-Report;Patients;Performance;pilot test;Polypharmacy;Population;Prefrontal Cortex;Prevention;Problem behavior;Process;Property;Proxy;psychiatric inpatient;Psychometrics;Quality of life;recruit;Reporting;Research;response;Risk;Sampling;School-Age Population;screening;Structure;Suicide;suicide rate;Symptoms;Testing;theories;Validation;Validity of Self Report;Variant;verbal;With laterality;Youth

PROJECT_TITLE: Change-Sensitive Assessment of Emotion Dysregulation in ASD Across the Lifespan


PHR: PROJECT NARRATIVE The regulation of the 1st wave of ovarian folliculogenesis, a highly organized process that is essential to produce mature and competent oocytes, remains largely unknown. As evidence indicates that sympathetic innervation may be involved in 1st wave follicle maturation, the goal of this proposal is to understand the interplay between ovarian sympathetic nerves and follicles to orchestrate the establishment of neuronal networks and how these networks contribute to folliculogenesis. This novel work is a significant step toward developing control points required for understanding ovarian development and nerve-associated disease etiology, such as polycystic ovarian syndrome.

PI_NAMEs: GAYLORD, ELIZA ANN (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: 3-Dimensional;Ablation;Adrenergic Agents;Adult;Affect;Age;autocrine;Autocrine Communication;Axon;Biology;Birth;cell type;Data;Data Set;Delayed Puberty;Destinations;Development;Disease;Etiology;Fellowship;Female;Fertility;folliculogenesis;Genetic;Glean;Goals;Gonadotropin Hormone Releasing Hormone;Gonadotropins;Graafian Follicles;Growing Follicle;Growth;Image;in vivo;Infertility;innovation;insight;Knowledge;Life;Ligands;Mammals;Maps;Measures;Mediating;Mentorship;Microscopy;Modeling;Morphology;mouse genetics;mouse model;Mus;Neonatal;Nerve;Nerve Endings;Nerve Fibers;nerve supply;Neurons;novel;oocyte maturation;Oocytes;Organ;Organogenesis;Ovarian;Ovarian Diseases;ovarian reserve;Ovary;Ovulation;paracrine;Paracrine Communication;Pathogenesis;Pattern;Peripheral;Peripheral Nerves;pharmacologic;Polycystic Ovary Syndrome;Presynaptic Terminals;Primordial Follicle;Process;Production;protein expression;Puberty;receptor;Regulation;reproductive;Reproductive Biology;Research;Role;Signal Transduction;Somatic Cell;Source;spatiotemporal;Testing;Three-Dimensional Imaging;Training;Transgenic Mice;United States;WNT Signaling Pathway;WNT5A gene;Woman;Work

PROJECT_TITLE: The Role and Branching Dynamics of Sympathetic Nerves in Ovarian Folliculogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-B(20)L]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Pediatric

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Neurodevelopmental and childhood disorders often arise due to abnormal neural development impacting function. The proposed research is relevant to public health because defining the developmental processes driving and constraining behavior will serve to increase our understanding of human health and treatment of developmental disorders. Therefore, this proposal is central to the NIH’s mission to increase fundamental knowledge of the mechanisms of disease, disorders, and dysfunction that impair health.

PI_NAMEs: LEARY, PAIGE  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Ablation;Address;Anatomy;Animal Behavior;Animals;assay development;associated symptom;Automobile Driving;Behavior;Biological Assay;Birth;Birth Order;Brain;Brain Stem;Childhood;Data;Date of birth;debilitating symptom;Development;developmental disease;Developmental Process;Disease;Ear;Event;experimental study;Eye Movements;Functional disorder;gain of function;gaze;Genetic;Goals;Head;Health;Human;Image;Impaired health;improved;Knowledge;Lesion;Link;Location;loss of function;Measures;Mission;Modeling;Motor Neurons;Movement;neural;neural circuit;neurodevelopment;Neurodevelopmental Disorder;neuronal circuitry;Neurons;Neurosciences;Nose;Optics;optogenetics;phenomenological models;Play;Population;Population Heterogeneity;predicting response;Property;Protocols documentation;Public Health;Research;response;Role;Sensory;serial imaging;Shapes;System;Technology;Testing;Time;United States National Institutes of Health;vestibular system;vestibulo-ocular reflex;Work;Zebrafish

PROJECT_TITLE: Developmental Contributions to the Functional Maturation of the Vestibulo-Ocular Reflex


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Neurosciences;Nutrition;Pain Research;Vector-Borne Diseases

ORG_CITY: SANTA BARBARA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: Project Narrative  Fatty acids act as powerful repellants at high concentrations while lower concentrations of fatty acids may act as attractive host cues for mosquito disease vectors like Aedes aegypti, yet the receptor mechanisms for fatty acid taste remain unclear in invertebrates. Our recent evidence in the fruit fly, Drosophila melanogaster, supports requirements for an opsin and a TRP channel in bimodal fatty acid taste in Aedes. We propose to leverage these results to reveal how the Aedes taste system mediates robust deterrence and attraction towards fatty acids.

PI_NAMEs: MORALES, ANGELA ELISA (contact)

PROJECT_TERMS: Aedes;Animals;Behavior;Behavioral;Behavioral Assay;Bite;Blood;Calcium;Cues;Culicidae;Data;Dengue;Desire for food;Detection;Dietary Component;Dietary Fats;Disease;Disease Vectors;Drosophila genus;Drosophila melanogaster;Economic Burden;egg;Electrophysiology (science);Esthesia;experimental study;Fatty acid glycerol esters;Fatty Acids;feeding;G-Protein-Coupled Receptors;Goals;Health;Healthcare Systems;Homologous Gene;Human;Image;improved;In Vitro;Individual;Insect Bites;insect disease vector;Insecta;insight;Invertebrates;Mediating;Modality;model organism;Molecular;Molecular Target;Morbidity - disease rate;mortality;Mosquito-borne infectious disease;mutant;Natural Compound;Neurons;Opsin;Organ;Pain;Painless;Partner in relationship;patch clamp;Peripheral;Persons;Phospholipase;Phospholipase C;Play;preference;receptor;response;Role;Sensory;Series;Skin;Source;sugar;Taste Perception;taste system;Testing;Time;transmission process;TRP channel;vector;vector control;Virus

PROJECT_TITLE: The molecular basis of fatty acid taste in Aedes aegypti


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Prostate Cancer;Radiation Oncology;Urologic Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE –  The goal of this submission is improve the treatment of bone metastatic cancer patients with Radium-223, the first approved alpha particle emitting drug, by understanding how it can be better used in combination with other therapies. Using information from extensive pilot data in the laboratory and clinical settings we evaluate synergistic Radium-223 combinations, characterize the potential for negative outcomes, and help explain findings emerging from clinical work. Our work will assist in the rational design of effective and safe combinations for alpha particle therapy to improve outcomes for late stage metastatic cancer patients.

PI_NAMEs: MICHALSKI, JEFF M.;THOREK, DANIEL LYNDON JAFFE (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: abiraterone;Ablation;absorption;Acetates;Active Sites;Address;Adverse event;Alpha Particle Emitter;Alpha Particles;Amiloride;androgen independent prostate cancer;Antitumor Response;Autoradiography;Basic Science;Biodistribution;Biological;Biomechanics;Biopsy;Blood;bone;Bone remodeling;bone turnover;Cancer Etiology;Cancer Patient;Cells;Cessation of life;Chemistry;Clinical;cohort;Combined Modality Therapy;Data;Defect;Deposition;Diagnosis;Discipline of Nuclear Medicine;Disease;disease model;Disseminated Malignant Neoplasm;Distress;Diuretics;DNA Repair;DNA Repair Inhibition;docetaxel;Dose;dosimetry;Drug Delivery Systems;Drug Kinetics;ds-DNA;Ensure;Enterocytes;Exhibits;falls;FDA approved;first-in-human;Fracture;Frequencies;gastrointestinal;Gastrointestinal tract structure;Gene Expression;genetic analysis;genomic data;Goals;Health;high throughput screening;Histologic;Histopathology;Human;Image;improved;improved outcome;In Vitro;in vivo;inhibitor;innovation;insight;interest;Investigation;irradiation;Knowledge;Laboratories;Lesion;male;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;men;Metastatic Neoplasm to the Bone;Modeling;Molecular;Monitor;monolayer;mortality risk;multidisciplinary;non-invasive imaging;novel strategies;novel therapeutics;Organ;Organoids;osteogenic;Outcome;particle therapy;Pathology;Patient observation;patient subsets;Patients;Pharmaceutical Preparations;pharmacologic;phase III trial;Physics;pre-clinical;Pre-Clinical Model;Prognosis;prostate cancer model;Quality of life;Radiation Oncology;Radiation therapy;Radiochemistry;Radioisotopes;Radiology Specialty;Radionuclide therapy;Radium;rational design;Reporting;Research;research clinical testing;response;Safety;Serum;side effect;Site;skills;synergism;System;Testing;Therapeutic;Time;Tissues;tool;Toxic effect;Toxicology;Treatment Efficacy;treatment strategy;uptake;Validation;Work

PROJECT_TITLE: The Radium-223 Combination Therapy Space; Improving Response and Clarifying Toxicities

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Mental Illness;Neurosciences

ORG_CITY: BOSTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: Narrative Adrenaline-like chemicals in the brain contributes to alertness, fear responses, learning and memory, and are implicated in the pathogenesis of several neurodegenerative disorders. This project aims to examine how these chemicals in the central nervous system regulate gene expression and activity in neurons in health and disease.

PI_NAMEs: MARTINEZ, JOSEPH M (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Adrenergic Receptor;Affect;alertness;Anatomy;Anhedonia;Animals;Anxiety;Anxiety Disorders;anxious individuals;Arousal;Basal Ganglia;Behavior;Behavioral;biological adaptation to stress;Brain;Brain region;Calcium;Cells;Central Nervous System;Chemicals;Chronic;Chronic stress;Clustered Regularly Interspaced Short Palindromic Repeats;cognitive function;Cues;Decision Making;Depressed mood;depressed patient;Depressive disorder;depressive symptoms;Development;differential expression;Disease;Disparate;dopaminergic neuron;Educational process of instructing;Electrophysiology (science);Emotional;Environment;Epinephrine;Evaluation;experience;Female;Fiber;Fluorescence;Fright;Future;Gene Expression;Genetic;Goals;Habenula;Health;Human;hypothalamic-pituitary-adrenal axis;Impairment;in vivo;Individual;Knock-out;Lateral;Learning;learning outcome;Major Depressive Disorder;male;Medial;Mediating;Memory;memory retrieval;Mental Depression;Midbrain structure;Mood Disorders;Mus;Nervous System Disorder;neural;Neurodegenerative Disorders;Neurons;Norepinephrine;Nose;novel;Outcome;patch clamp;Pathogenesis;Patients;Pattern;Performance;Peripheral;Phenotype;Photometry;Play;Positioning Attribute;Procedures;Process;Proxy;Psychosocial Stress;Punishment;receptor;receptor expression;Recording of previous events;response;Rewards;Risk Factors;Role;sensor;Sensory;Signal Transduction;single cell sequencing;Speed;Stimulus;Stress;stress disorder;Testing;tool;transcriptome;Transgenic Mice;Transgenic Organisms;Treatment/Psychosocial Effects;Uncertainty;Update;Variant

PROJECT_TITLE: NE contributions to Lateral habenula control of action evaluation under chronic stress


ADMINISTERING_IC: OD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

PHR: Narrative—Overall The Caenorhabditis Genetics Center (CGC) is the sole general international repository and distribution center for the nematode C. elegans. Researchers throughout the world make important discoveries in diverse areas of biology, many with relevance to human health, aging and disease, using this premier model organism and strains provided by the CGC. A small research component will quantitatively compare in vivo parameters of a new set of fluorescent proteins in the nematode, enabling scientists to choose the optimal proteins for use in their work.

PI_NAMEs: DAUL, ARIC L;ROUGVIE, ANN E. (contact)

PROGRAM_OFFICER_NAME: ZOU, SIGE

PROJECT_TERMS: Aging;animal resource;Animals;Anthelmintics;Apoptosis;Applied Research;Area;Basic Science;Biological;Biology;Biomedical Research;Caenorhabditis;Caenorhabditis elegans;Cell Aging;Chromosomal Rearrangement;Collection;Color;Communities;cost;Country;CRISPR/Cas technology;Cryopreservation;design;Developmental Process;Disease;Education;Educational process of instructing;Ensure;Equipment;Fees;Future;gene induction;Gene Proteins;Genes;Genetic;Goals;Growth;Health;Human;In Vitro;in vivo;in vivo evaluation;Individual;insight;International;Laboratories;Livestock;Locales;Location;Measures;member;MicroRNAs;Microscopy;Mission;model organism;Modeling;Monitor;mutant;Nematoda;Neurodegenerative Disorders;null mutation;Parasites;Parasitic nematode;Performance;Persons;preservation;Property;Proteins;Protocols documentation;Publishing;repository;Reproducibility;Research;Research Personnel;Research Project Grants;research study;Research Support;Resources;RNA Interference;Safety;Scheme;Science;Scientist;Services;Signal Transduction;System;Techniques;tool;Training;tumor progression;Work

PROJECT_TITLE: Caenorhabditis Genetics Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-G(55)R]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

PI_NAMEs: ROUGVIE, ANN E. (contact)

PROJECT_TERMS: Alzheimer's Disease;Animals;Anthelmintics;Apoptosis;Area;Auxins;axon guidance;Biological;Biology;Budgets;Caenorhabditis;Caenorhabditis elegans;Chromosomal Rearrangement;Collection;Communities;cost;Cost Savings;Country;Cryopreservation;Cues;Disease;disease model;education research;Educational process of instructing;experience;Fees;Funding;Genes;Genetic;Germ;Goals;Grant;Health;Human Development;Individual;insight;interest;International;Laboratories;Locales;MicroRNAs;Minnesota;Mission;model organism;model organisms databases;Modeling;Mus;mutant;Mutation;Nematoda;Nematode infections;Neurodegenerative Disorders;null mutation;Parasitic nematode;Parkinson Disease;Pharmaceutical Preparations;Plants;Policies;prevent;Proteins;Publishing;Recovery;Research;Research Personnel;Resources;response;RNA Interference;Savings;Scheme;science teacher;Services;Site;System;tool;Transgenic Organisms;tumor progression;United States;United States National Institutes of Health;Universities;Update;web site;WormBase

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-G]


NIH_SPENDING_CATS: Genetics

PROJECT_TERMS: Adopted;Adoption;Animal Model;apical membrane;Applied Research;automated segmentation;Automobile Driving;Behavior;Biomedical Research;Caenorhabditis;Caenorhabditis elegans;Cell Nucleus;Cells;Characteristics;Chimeric Proteins;Codon Nucleotides;Collaborations;Collection;Color;Communities;CRISPR/Cas technology;Data;design;Detection;Development;dlg protein;Engineering;Ensure;Environmental Impact;Equipment;Experimental Designs;Future;Gene Expression;Gene Expression Profiling;Gene Proteins;Gene Transfer Techniques;Genes;Genetic;Genome engineering;genomic locus;Green Fluorescent Proteins;Image;improved;In Vitro;in vivo;in vivo evaluation;interest;Introns;Investments;Laboratories;member;Methods;Microscope;Microscopy;model organism;Monitor;Nematoda;Neurons;North Carolina;optical spectra;Organism;Performance;Property;Proteins;Reagent;repaired;Reproducibility;Research;Research Personnel;Scanning;Scientist;Site;System;Testing;Time;transcription factor;Transgenic Animals;Uncertainty;Universities;Variant;virtual;Work

PROJECT_TITLE: Enhancing and expanding the CGC Strain Collection


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Behavioral and Social Science;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Physical Rehabilitation;Rehabilitation

ORG_CITY: Los Angeles

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Data science methods provide an exciting opportunity to significantly improve the rigor of rehabilitation research by increasing the reproducibility and replicability of research. Data science methods, which rely on computer programming skills for data intake, management, storage, and analysis, can increase reproducibility, but clinical and basic rehabilitation researchers may have challenges adopting these practices due to a lack fundamental training in computer programming. The proposed Reproducible Rehabilitation (ReproRehab) research education program will build a sustainable national workforce of rehabilitation researchers equipped with basic data science skills by: (1) implementing an innovative, hands-on bootcamp for rehabilitation researchers to learn beginning data science skills and integrate them into their own research, (2) employing a train-the-trainer model to rapidly increase capacity for data science and training of data science in the rehabilitation research community, and (3) broadly disseminating data science resources curated specifically for rehabilitation researchers through a publicly accessible web portal.

PI_NAMEs: KENNEDY, DAVID NELSON;LIEW, SOOK-LEI  (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Address;Adopted;Adoption;Area;Artificial Intelligence;Clinical;Code;Communities;Complex;computer program;Computing Methodologies;Consultations;cost effective;Data;Data Analyses;data archive;data dissemination;data management;Data Pooling;Data Science;data science resource;Data Set;data sharing;Databases;education research;Educational process of instructing;experience;Goals;Grant;Growth;Hour;improved;innovation;Intake;Internet;Kinesiology;Knowledge;Leadership;Learning;learning materials;machine learning method;Medicine;meetings;member;Mentors;Mentorship;Methodological Studies;Methods;Modeling;Neurosciences;Occupational Therapy;online course;online repository;online resource;open source;Outcome;Paper;Performance;Phase;Physical therapy;programs;Protocols documentation;Records;rehabilitation research;rehabilitation science;Rehabilitation therapy;Reporting;Reproducibility;Research;Research Personnel;Resources;Sampling;Scientist;Site;skills;Speech Therapy;symposium;Teaching Materials;tool;Trainers Training;Training;training data;United States National Institutes of Health;Update;web portal

PROJECT_TITLE: Building a data science workforce to improve the reproducibility of rehabilitation research

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD-K]


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Rehabilitation

PHR: 8. PROJECT NARRATIVE This project proposes to develop and validate the Adult Functioning Scale, a self- and caregiver-report assessment of social, employment, and independent living domains suitable for use in treatment trials for adults with developmental disabilities. The results from this project are of considerable public health significance in that they will establish a measure of functional outcome for adults with developmental disabilities that is broadly applicable across different conditions and severity spectra, and that can be used to monitor treatment changes in clinical trials seeking to improve functioning in adults with autism spectrum disorder and other developmental disabilities.

PI_NAMEs: EACK, SHAUN M;MAZEFSKY, CARLA A (contact)

PROJECT_TERMS: Adaptive Behaviors;Adult;adult with autism spectrum disorder;Age;autism spectrum disorder;biological sex;Calibration;Caregivers;Categories;Child;Childhood;Clinical;Clinical Trials;cognitive interview;Communities;Comprehension;design;Development;Developmental Disabilities;Diagnosis;Dimensions;Disabilities experience;disability;Disability research;Down's Syndrome;emotion dysregulation;Employment;Ensure;Equipment and supply inventories;Evaluation;Evidence based treatment;experience;Factor Analysis;Family;Fragile X Syndrome;Functional impairment;functional improvement;functional outcomes;Group Homes;improved;Independent Living;Individual;Information Systems;Inpatients;Intellectual functioning disability;Intervention;Intervention Studies;Knowledge;Life;Loneliness;Measurement;Measures;Methodology;Methods;Modeling;Monitor;Mood Disorders;Neurodevelopmental Disorder;neuropsychiatry;novel;Occupations;Outcome;Outcome Measure;Outpatients;Parents;Participant;Patient Outcomes Assessments;Patient Self-Report;Patients;Population;Property;Proxy;psychiatric inpatient;Psychometrics;Public Health;Reporter;Reporting;Research;response;Sampling;Schizophrenia;service providers;Severities;skills;social;social deficits;Social Functioning;Social isolation;Societies;sound;success;Symptoms;Testing;theories;therapy development;Time;treatment effect;treatment trial;Underserved Population;United States National Institutes of Health;Validity and Reliability;verbal

PROJECT_TITLE: Change-sensitive Measurement of Adult Functional Outcomes in Developmental Disabilities


NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HOUSTON

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE In this proposal, we expect to gain substantial insight into how stem cells and their niches can be newly generated through developmental plasticity of differentiated cells during craniofacial skeletal development, and how cells in postnatal stages retain such potential for plasticity. This study will thus guide our future efforts to capitalize on lineage plasticity to achieve autotherapies for the postnatal craniofacial skeletal defects, by aiding to develop innovative approaches to recover inherent stem cells and their niches that support proper growth and regeneration of multiple functional units of the craniofacial skeletal tissues.

PI_NAMEs: ONO, NORIAKI  (contact);ONO, WANIDA ;WELCH, JOSHUA

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: Adult;Alleles;Alveolar Bone Loss;ATAC-seq;Bar Codes;bone;Cartilage;Cell Differentiation process;Cell Line;Cell Lineage;cell motility;Cell Therapy;Cells;Cementoblast;Chondrocytes;comparative;craniofacial;CRISPR screen;Dedications;Defect;Deformity;Dental;Dental Sac;Development;developmental plasticity;epigenomics;Epiphysial cartilage;Event;experimental study;Fibroblasts;Functional Regeneration;Future;Genes;Growth;In Vitro;in vivo;innovation;insight;Life;Ligature;Mastication;Mesenchymal Stem Cells;mineralization;Modeling;Molecular;Natural regeneration;overexpression;parathyroid hormone-related protein;Periodontal Diseases;Periodontal Ligament;Periodontitis;Periodontium;Phase;Physiologic Ossification;Play;postnatal;reconstitution;Recovery;Regenerative capacity;Reporting;Resolution;Rest;Role;skeletal;Skeletal Development;skeletal tissue;skull base;Slide;Source;stem cell niche;stem cells;Surface;Surgical sutures;Technology;Testing;Time;Tissues;Tooth root structure;Tooth structure;transcriptome sequencing;transcriptomics;vector

PROJECT_TITLE: Craniofacial skeletal cell lineage plasticity for reconstituting stem cells and their niches


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Dissemination and Implementation Research

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Implementation science is the field that studies how to move evidence-based treatments, therapies, and techniques into clinics and hospitals quickly so that patients can benefit from them. Currently, there are not enough scientists in the field and it takes approximately 17 years for new treatments to be adopted by the medical community. This program will train new scientists in implementation science so we can take better care of people with heart, lung, blood, or sleep disorders.

PI_NAMEs: SPIEGELMAN, DONNA L (contact);VELAZQUEZ, ERIC J

PROGRAM_OFFICER_NAME: KHAN, SHAHNAZ

PROJECT_TITLE: Training in Implementation Science Research and Methods

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SANTA CRUZ

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: Project Narrative The proposed research is relevant to public health because the ability to discern the location of a sound source is an important brain function in humans; errors in these computations are known to be associated with deficits in hearing and communication. The goal of this research plan is to determine how auditory information is processed in the superior colliculus, the only area in the brain known to contain a topographic map of auditory space. Findings from this research will provide fundamental knowledge that will enable additional research to better understand and treat disorders that involve auditory processing.

PI_NAMEs: FELDHEIM, DAVID A (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Animals;Area;Auditory;Auditory area;auditory processing;auditory stimulus;Auditory system;awake;Brain;Brain Stem;Cell Nucleus;cell type;Code;Communication;Complex;Cues;Data Analyses;Dependence;Disease;Ear;experimental study;Ferrets;Frequencies;Genetic;Goals;Head;Hearing;Human;Inferior Colliculus;Inherited;Knowledge;large datasets;Lateral lemniscus;Light;Location;Locomotion;Mammals;Maps;Measures;Midbrain structure;Modeling;Modification;Molecular;Mus;Nature;neural;Neurodevelopmental Disorder;neuronal circuitry;Neurons;optogenetics;Organism;Pattern;Perception;Play;Population;Primates;Process;Property;Public Health;receptive field;Research;response;Role;Running;Scheme;Shapes;Silicon;sound;Sound Localization;Source;spatial integration;spatiotemporal;superior colliculus Corpora quadrigemina;Testing;tool;treadmill;two-dimensional;visual map;Visuospatial;Work

PROJECT_TITLE: Coding of auditory space in the mouse superior colliculus

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: Despite its importance to normal brain function, neural decoding is much more poorly understood than the process of neural encoding. This proposal applies innovative methods to develop fundamental new knowledge about the circuit, cellular, and synaptic mechanisms of neural decoding. An improved understanding of how the brain processes its own sensory code could help guide the development of improved therapies for rehabilitation after brain injury.

PI_NAMEs: JEANNE, JAMES MCCLURE (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TITLE: Neural mechanisms for decoding olfactory information in Drosophila

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Contraception/Reproduction;Estrogen;Infertility;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Transplantation;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative The proposed research aims to restore ovarian endocrine function in young women with premature ovarian insufficiency by utilizing human xenogeneic implantation of ovarian tissue in immuno-isolating hydrogel-based capsule. We will engineer a synthetic hydrogel based capsule with spatially controlled degradation that maximizes the survival and function of ovarian xenograft in vivo. The primary innovation of this proposal stems from the design of immuno-isolating capsule that considers the uniqueness of the physiology of human ovarian tissue, while using well-characterized biomaterials.

PI_NAMEs: SHIKANOV, ARIELLA  (contact)

PROJECT_TERMS: Acceleration;Affect;Allogenic;Allografting;anti-cancer treatment;Autologous Transplantation;Biocompatible Materials;Bone Marrow Transplantation;cancer cell;cancer recurrence;cancer risk;Cancer Survivor;cancer therapy;capsule;Cardiovascular Diseases;Cells;chemotherapy;Chemotherapy and/or radiation;Child;Circulation;clinical translation;clinically relevant;cognitive development;cohort;Complication;cytotoxic;Data;design;Devices;Diabetes Mellitus;Diffusion;Disease remission;Dose;Encapsulated;Endocrine;Engineering;Equilibrium;Estrogen deficiency;Estrogens;Estrus;ethylene glycol;Event;Exposure to;Face;Female;Female Adolescents;Fertility;Follicle Stimulating Hormone;folliculogenesis;Formulation;Freezing;Funding;girls;Goals;graft function;Growth;Health;Hematologic Neoplasms;Homologous Transplantation;Hormonal;Hormone imbalance;Hormone replacement therapy;Human;human model;human tissue;Hydrogels;Immune;Immune response;Immunocompetent;Immunocompromised Host;immunodeficiency;Immunologic Sensitization;Immunologics;Immunosuppression;Implant;implantation;improved;in vivo;innovation;Investigation;Isoantibodies;isoimmunity;Laboratory mice;Life;Longevity;loss of function;Malignant Breast Neoplasm;Malignant Childhood Neoplasm;Memory;meter;millimeter;Modeling;Modernization;Mus;Muscular Atrophy;Nature;novel;Obesity;Osteopenia;Ovarian;Ovarian hormone;Ovarian Tissue;Ovarian tissue cryopreservation;Ovariectomy;Pattern;Periodicity;Physiological;Physiology;premature;preservation;prevent;primary ovarian insufficiency;Progesterone;Property;Puberty;Research;response;Risk;Rodent;Skin graft;standard of care;stem;Sterility;Stimulus;Survival Rate;Testing;thrombotic;Tissue Donors;Tissue Grafts;Tissues;tool;Transplantation;Treatment-related toxicity;United States;Xenograft procedure;young woman

PROJECT_TITLE: Engineering an immuno-isolating hydrogel for restoring ovarian endocrine function


NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: PROJECT NARRATIVE While current understanding of hearing mechanics in the human cochlea has largely been inferred from animal experiments, our recent findings have revealed that there are substantial differences between the cochlear partition motions in humans and laboratory animals that would influence the mechanical input to the transduction mechanism. To determine how auditory mechanics work in humans, we will measure the cochlear partition motion of very fresh human cadaveric ears, investigate relevant cochlear anatomical properties, and incorporate the resulting motion and anatomical information into computational models that will allow us to further investigate and explain human cochlear behavior. Our proposed research will advance our understanding of human hearing mechanics to elucidate how the cochlea functions (e.g., to achieve sensitive hearing and fine frequency discrimination), enable us to better understand the applicability and limitations of animal experiments for human hearing, and result in computational models that are valuable for both scientific investigation and for improving the diagnosis and treatment of hearing disease.

PI_NAMEs: NAKAJIMA, HIDEKO HEIDI (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: 3-Dimensional;Affect;Anatomy;Animal Experiments;Animal Model;Animals;Architecture;Auditory;Automobile Driving;Autopsy;Basilar Membrane;Behavior;Bone Conduction;Cadaver;Cavia;Characteristics;Chinchilla (genus);Cochlea;Cochlear duct;comparative;Computer Models;Coupled;Data;Development;Diagnosis;Discrimination;Ear;Elements;Etiology;Felis catus;flexibility;Frequencies;Fresh Tissue;Future;Gerbils;Hair;Hair Cells;Hearing;Hearing problem;Histologic;Histology;Hour;Human;human model;Image;improved;In Situ;Inner Hair Cells;Investigation;Knowledge;Laboratory Animals;Learning;Location;Mammals;Measurement;Measures;mechanical drive;Mechanics;Microscopy;Modeling;morphometry;Motion;Mus;Names;Optical Coherence Tomography;Organ of Corti;Outer Hair Cells;Pathology;Pillar Cell;Preparation;pressure;Process;Property;Psychoacoustics;Radial;reconstruction;Research;Research Personnel;Resolution;Rest;Rotation;Scanning Electron Microscopy;Scientific Inquiry;Sensorineural Hearing Loss;soft tissue;Specimen;Spiral Lamina;Structure;Surface;Techniques;tectorial membrane;Testing;Time;Tissues;Transducers;Translations;vibration;Visual;Work;X-Ray Computed Tomography

PROJECT_TITLE: Human Cochlear Structure & Function


NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Transplantation;Urologic Diseases

ORG_CITY: CALGARY

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY OF CALGARY

ORG_STATE: AB

ORG_ZIPCODE: T2N 1N4

PHR: Project Narrative To study and design treatments for human diseases requires appropriate animal models. Despite the availability of many rodent models, findings in rodents do not readily translate to human patients but large animal models, such as pigs and non-human primates, closely resemble human physiology and size. This project will provide a novel strategy for precise genetic modification in testis stem cells to generate large animal models of human diseases and for regenerative medicine, and will establish accessible systems to study germline stem cell biology in non-rodent animals.

PI_NAMEs: DOBRINSKI, INA  (contact)

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Ablation;Adult;Alleles;Animal Model;Animals;Autophagocytosis;Award;Biological Markers;Cell Communication;Cell Culture System;Cell Differentiation process;Cell Physiology;cell type;Cells;Chromosomes;Cilia;Complex;CRISPR/Cas technology;Cultured Cells;Data;design;Development;disease model;DNA Sequence Alteration;ds-DNA;Embryo;Environment;Epigenetic Process;Equilibrium;Family suidae;Fertilization in Vitro;Future Generations;Gene Dosage;gene editing technology;Gene Targeting;Genes;Genetic;genome editing;Germ;Germ Cells;Germ Lines;germline stem cells;glucose metabolism;Goals;Homologous Transplantation;Human;human disease;human model;Immunodeficient Mouse;improved;In Vitro;in vivo;induced pluripotent stem cell;Insulin;male;Mediating;Metabolic;Metabolic Pathway;metabolic phenotype;Modification;Monitor;Morphogenesis;Mus;mutant;Mutation;nonhuman primate;novel;novel strategies;nuclease;Nutrient availability;Organoids;oxidative damage;Oxygen Consumption;Patients;Permanent neonatal diabetes mellitus;Phylogenetic Analysis;Physiological;Physiology;pig genome;Play;pluripotent stem cell differentiation;postnatal;Pre-Clinical Model;pre-clinical research;Proliferating;Protocols documentation;Recombinant adeno-associated virus (rAAV);reconstitution;Regenerative Medicine;repaired;Ribonucleoproteins;Rodent;Rodent Model;Role;screening;self-renewal;sertoli cell;Signal Pathway;Single-Stranded DNA;Somatic Cell;sperm cell;Spermatogenesis;stem cell biology;stem cell differentiation;stem cell expansion;stem cell function;stem cell niche;stem cell proliferation;Stem cell transplant;stem cells;System;Testing;Testis;therapy design;Time;Tissues;Toxic effect;Transgenes;Translating;transmission process;Transplantation;Tubular formation;Work;Xenograft procedure

PROJECT_TITLE: Transplantation of Testis Stem Cells in Large Animals

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-F(55)R]