NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Wound Healing and Care

ORG_CITY: LUBBOCK

ORG_DEPT: BIOLOGY

ORG_NAME: TEXAS TECH UNIVERSITY

PHR: Project Narrative Chronic bacterial infections such as those associated with certain wound and lung comorbidities can persist for months, years, and even decades. Failure to clear these infections despite prolonged treatment with antibiotics creates a selective pressure enabling the evolutionary emergence and dissemination of novel antibiotic resistance mechanisms within problematic human pathogens. If treatment strategies are better targeted towards aspects of the chronic infection environment, the efficacy of the currently available repertoire of clinically approved antibiotic compounds can be extended.

PI_NAMEs: WAKEMAN, CATHERINE ANN (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: antagonist;anti-microbial drug;anti-microbial tolerance;Antibiotic Resistance;Antibiotic susceptibility;Antibiotic Therapy;antibiotic tolerance;Antibiotics;Automobile Driving;bacterial community;Bacterial Infections;Caring;Cell Physiology;Cells;Cessation of life;Chemicals;Chronic;chronic infection;chronic wound;Clinical;clinical application;Clinical Microbiology;Clinical Treatment;combinatorial;Combined Antibiotics;commensal microbes;Communicable Diseases;Communities;comorbidity;Complex;Complex Mixtures;coping;Data;design;Development;DNA cassette;effectiveness evaluation;emerging antibiotic resistance;Environment;Evolution;Exhibits;experience;Failure;Future;Gene Exchanges;global health;Horizontal Gene Transfer;Human;human morbidity;human mortality;human pathogen;improved;Infection;Knowledge;Laboratories;Life Expectancy;Lung;Lung infections;Medical;member;Methodology;Microbe;microbial;microbial community;microorganism;microorganism interaction;Modeling;Modern Medicine;mouse model;Mutation;Nature;novel;pathogen;pathogenic microbe;Pharmaceutical Preparations;Physiological;Physiology;population health;Predisposition;pressure;Publishing;Research;Research Project Grants;Resistance;resistance mechanism;Site;Source;stressor;synergism;targeted treatment;Testing;Therapeutic;therapy design;tool;translational potential;Treatment Failure;treatment strategy;wound;Wound Infection

PROJECT_TITLE: Strategies for improving the efficacy of combinatorial antibiotic therapy in chronic infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIRT-J(01)]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: HOSPITALS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Colorectal Cancer;Digestive Diseases;Immunization;Immunotherapy;Women's Health Research

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE/RELEVANCE  The proposal aims to develop a novel bispecific antibody targeting human epidermal growth factor receptor-2 (HER2) and vascular endothelial growth factor A. If the study is successful, this bispecific antibody could be tested in clinical trials for patients with HER2-overexpressing colorectal cancer that responds to bevacizumab and could also respond to trastuzumab, the current gold-standard treatment for HER2- overexpressing breast cancer. Ultimately, the work may lead to a new therapy to reduce deaths from metastasis and recurrence of HER2-overexpressing colorectal cancer.

PI_NAMEs: FAN, ZHEN  (contact)

PROGRAM_OFFICER_NAME: BOURCIER, KATARZYNA

PROJECT_TERMS: adaptive immune response;Angiogenesis Inhibition;Antibodies;Antibody Therapy;antigen-specific T cells;Automobile Driving;bevacizumab;Binding;Biological Assay;Bispecific Antibodies;cancer cell;cancer therapy;cancer type;CD19 gene;CD3 Antigens;cell killing;Cell surface;Cells;Cessation of life;Clinical Trials;Clonal Expansion;colon cancer patients;Colorectal Cancer;CTL assay;cytokine;Cytometry;design;Development;Disseminated Malignant Neoplasm;Engineering;Epidermal Growth Factor Receptor;Epitopes;Exhibits;Future;Genomics;Goals;Growth Factor;Growth Factor Receptors;Hematologic Neoplasms;Human;humanized mouse;IgG1;Immune;Immune response;Immunosuppression;Implant;improved;Interferon Type II;Interleukin-10;KDR gene;Malignant Breast Neoplasm;Malignant Neoplasms;malignant stomach neoplasm;Measures;Mediating;metastatic colorectal;Modeling;Monoclonal Antibodies;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutics;Oncogenes;Oncogenic;overexpression;patient derived xenograft model;Patients;Peptides;Phagocytosis;Play;Pre-Clinical Model;Production;receptor;reconstitution;Recurrence;research clinical testing;rituximab;Role;Solid Neoplasm;Specificity;standard care;T cell infiltration;T cell receptor repertoire sequencing;T-Cell Depletion;T-Lymphocyte;Testing;Therapeutic;Therapeutic antibodies;Time;Transforming Growth Factor beta;translational potential;Trastuzumab;tumor;Tumor Angiogenesis;Tumor Antibodies;tumor microenvironment;tumor progression;Tumor Promotion;Vaccines;VEGFA gene;Work

PROJECT_TITLE: Developing novel bispecific antibodies for cancer treatment

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Genetics

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Regulatory T cells (Tregs) are immune suppressors that maintain the immune system balance. The goal of this project is to define the role of REV-ERB in the RORgt+ Tregs. The proposed research will reveal the molecular mechanisms underlying Treg’s protective function in colon inflammation, which can potentially lead to the development of novel therapeutic targets for inflammatory bowel disease.

PI_NAMEs: ZHENG, YE  (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Agonist;anti-tumor immune response;Antibodies;Autoimmune Diseases;Autoimmunity;Binding;Biological Assay;Cell Lineage;Cell Physiology;Cells;Cleavage Under Targets and Release Using Nuclease;Colon;Colonic inflammation;conditional knockout;CTLA4 gene;Data;Development;Equilibrium;experimental study;Family;FOXP3 gene;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;genome-wide;Goals;Homeostasis;Human;Immune system;immunopathology;Immunosuppressive Agents;in vivo;in vivo Model;Inflammation;Inflammatory;Inflammatory Bowel Diseases;insight;Insulin-Dependent Diabetes Mellitus;Interleukin-10;Knock-out;Knockout Mice;Lamina Propria;Lead;Link;loss of function mutation;Lymphoproliferative Disorders;Maintenance;Maps;Mediating;member;Molecular;mouse model;Multiple Sclerosis;murine colitis;Mus;new therapeutic target;next generation sequencing;Nuclear Hormone Receptors;Nuclear Receptors;Orphan;Outcome;Outcome Study;Play;Population;Predisposition;prevent;protective effect;receptor;receptor function;Receptor Inhibition;Regulatory T-Lymphocyte;Repression;Research;Role;Side;Spleen;T-Lymphocyte;Testing;therapeutic development;therapeutic target;Tissues;Transcription Coactivator;transcription factor;Transcription Factor 3;Transcription Repressor;transcriptome sequencing;Tretinoin;trinitrobenzene sulfonic acid induced colitis;Work

PROJECT_TITLE: Define the role of REV-ERB in colonic RORgt+ regulatory T cells


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: KENSINGTON

ORG_NAME: TENDEL THERAPIES INC.

PHR: Narrative Deliverables of this proposal will provide the needed investigational products and toxicology data, as well as additional supportive mechanistic data, to support comparative phase-1 testing of a SARS-Cov-2 vaccine candidate that incorporates a novel genetic adjuvant designed to induce antiviral neutralizing antibodies of superior magnitude, breadth, and durability.

PI_NAMEs: SPARGER, ELLEN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: Acceleration;Adenoviruses;Adjuvant;Antibody Response;Antibody titer measurement;Antigens;B-Cell Development;B-Lymphocytes;booster vaccine;California;CD3 Antigens;Chimeric Proteins;Clinical;Clinical Trials;comparative;Complex;cost;COVID-19 booster;COVID-19 vaccine;Data;deep sequencing;delivery vehicle;design;Development;Dose;FDA approved;Feedback;first-in-human;Funding;Genetic;Genome;genome sequencing;Goals;Good Manufacturing Process;Helper-Inducer T-Lymphocyte;high dimensionality;Human;immunogenicity;Immunoglobulin Fragments;Laboratories;Letters;Libraries;Macaca;manufacture;manufacturing process;manufacturing run;Monoclonal Antibody HuM291;neutralizing antibody;next generation sequencing;nonhuman primate;novel;novel strategies;novel vaccines;particle;Persons;Phase;phase 1 testing;phase I trial;plasmid DNA;pre-clinical;Production;programs;Qualifying;receptor binding;recruit;regenerative;resilience;response;RNA vaccine;Running;Safety;safety study;safety testing;SARS-CoV-2 B.1.1.529;Serial Passage;T-Lymphocyte;Techniques;Testing;tool;Toxicology;Transfection;trial design;United States National Institutes of Health;vaccine candidate;Vaccines;vector;Vial device;Viral;viral detection;Virus;Work

PROJECT_TITLE: GMP production and GLP safety of bidirectionally targeted SARS-CoV-2 booster vaccine

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-D(10)]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: WASHINGTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Nearly 6 million older Americans have dementia that causes difficulty with reasoning and remembering, and yet there are no drugs to cure or prevent it. The development of new drugs typically costs about $3 billion and takes about ten years. We propose an innovative artificial intelligence-based approach to examine data from millions of Veterans and their medications to efficiently identify drugs that may delay onset of dementia.

PI_NAMEs: AHMED, ALI ;ZAMRINI, EDWARD Y;ZENG, QING  (contact)

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: Acceleration;Accidents;Aducanumab;African American;African American population;Alzheimer's Disease;Alzheimer's disease related dementia;American;Artificial Intelligence;artificial intelligence model;Autopsy;Bioinformatics;Blinded;Brain;candidate identification;candidate selection;case control;Clinical;Clinical Data;clinical database;Clinical Trials;cohort;Cohort Studies;Combined Modality Therapy;cost;cost effective;Data;Databases;deep learning;deep learning model;Dementia;design;Development;Disease;dosage;Dose;drug candidate;Drug Prescriptions;drug repurposing;Elderly;Electronic Health Record;Emotional;experience;Family;FDA approved;Financial Hardship;fitness;follow-up;frailty;Future;genome wide association study;human old age (65+);innovation;insight;interest;Learning;Life;Link;Machine Learning;Medicare;Medicare claim;Methods;Natural Language Processing;Neurologist;novel;novel therapeutics;Outcome;Pathology;Pathway interactions;patient subsets;Patients;Pharmaceutical Preparations;Pharmacy facility;Phase;Phenotype;Positioning Attribute;prevent;Prevention;Procedures;Process;Public Health;Randomized, Controlled Trials;Recommendation;Recording of previous events;Records;response;Sample Size;screening;Signal Transduction;Societies;Statistical Methods;Structural Models;Structure;Study models;Surrogate Endpoint;Symptoms;Testing;therapy development;Time;tool;Training;United States Centers for Medicare and Medicaid Services;United States Department of Veterans Affairs;Validation;Veterans;Woman

PROJECT_TITLE: MWAS+ – A Novel Drug Repurposing Strategy for ADRD Prevention


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: FAIRFAX

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: GEORGE MASON UNIVERSITY

ORG_STATE: VA

PHR: We have discovered a new mitochondrial metabolic adaptation process, called secretory mitophagy, that used by cancer cells to survive under the stress of chemotherapy, radiotherapy, and molecular therapy. Under the Aims we will explore the molecular controls of this process in vitro, and in vivo, because it constitutes a new therapeutic target, and a clinically-relevant means to monitor the ongoing efficacy of cancer therapy.

PI_NAMEs: HOWARD, MARISSA ASHTON (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: 4T1;aspirate;Autophagocytosis;Autophagosome;bafilomycin A1;Biogenesis;Breast Cancer cell line;cancer cell;cancer therapy;Cell Survival;Cells;chemotherapy;Chloroquine;clinically relevant;Culture Media;DNA Damage;Docking;extracellular;extracellular vesicles;Fluorescence;Goals;Harvest;Human;Hypoxia;Immune;Immunotherapy;improved;In Vitro;in vivo;in vivo monitoring;Intercellular Fluid;knock-down;Knock-out;Knowledge;Length;Link;Lysosomes;Malignant Neoplasms;Mammary Neoplasms;MDA MB 231;Measurement;Metabolic;Methods;Mitochondria;Mitochondrial DNA;Mitochondrial Proteins;mitochondrial therapeutics;Molecular;Molecular Analysis;Monitor;Morphology;Mus;Needles;neoplastic cell;new therapeutic target;Organelles;Outcome;Oxidative Stress;Oxidative Stress Induction;particle;Pathway interactions;Peripheral;Phenotype;PINK1 gene;Population;pressure;prevent;Process;Protein Export Pathway;Proteins;Publishing;Radiation therapy;real time monitoring;recruit;Role;Sampling;sensor;Sirolimus;Solid Neoplasm;Stress;System;Testing;therapeutic target;therapy resistant;tool;triple-negative invasive breast carcinoma;tumor;tumor microenvironment;tumor progression

PROJECT_TITLE: Secretory Mitophagy in Cancer Metabolic Reprogramming

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BTC-J(55)R]


ORG_CITY: STANFORD

ORG_DEPT: BIOPHYSICS

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE: Immunoregulatory cytokines are being deployed to fight cancer, but require fine-tuning to function as drugs or they can be ineffective and/or toxic. We are using structure-informed protein engineering to tune how cytokine “master regulators” signal via Janus Kinases to develop candidates for cancer immunotherapy.

PI_NAMEs: GARCIA, KENAN CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: 3-Dimensional;Address;Agonist;analog;anti-tumor agent;Antineoplastic Agents;antitumor effect;Architecture;Award;Binding;Biological;cancer immunotherapeutics;cancer immunotherapy;cancer therapy;CD8B1 gene;cell type;Cells;Chemistry;Complex;Cryoelectron Microscopy;cytokine;Cytokine Receptors;Cytokine Signaling;design;Dimerization;Dose Limiting;Engineering;exhaustion;extracellular;fighting;G-Protein-Coupled Receptors;Grant;Hand;Homeostasis;Homo;Image;Immune;Immune system;immunoengineering;immunoregulation;Immunotherapeutic agent;improved;in vivo;Interferons;Interleukin 2 Receptor;Interleukin 2 Receptor Gamma;Interleukin-10;Interleukin-12;interleukin-12 receptor;Interleukin-2;interleukin-21;interleukin-22;interleukin-23;JAK1 gene;JAK3 gene;Janus kinase;Knowledge;Length;leukocyte proliferation;Ligands;Malignant Neoplasms;Mediating;Membrane;Molecular;Mus;nanobodies;Natural Killer Cells;Outcome;Paint;Pattern;Pharmaceutical Preparations;pharmacologic;Play;pleiotropism;preference;Property;Protein Engineering;receptor;Receptor Signaling;reconstitution;Reporting;Role;Signal Transduction;Specificity;stemness;structural biology;Structure;Structure-Activity Relationship;System;systemic toxicity;T-Lymphocyte;Therapeutic;Toxic effect;translational barrier;Translations;tumor;tumor immunology;Variant

PROJECT_TITLE: Structure-based engineering of immune cytokine signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIO-D(01)Q]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences;Pediatric

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: The NeuroNEXT Network was developed to facilitate phase II clinical trials in neurological disorders through partnerships with universities, private foundations, and industry. Vanderbilt has been a site in the NeuroNEXT network for the past 10 years and has participated in nine NeuroNEXT trials, utilizing our research enterprise and extensive resources to deliver high enrollment and retention of study participants. We look forward to investigating diverse neurological disorders in both adults and children for future NeuroNEXT concept proposals and clinical trials.

PI_NAMEs: CHARLES, PHILIP DAVID;PELTIER, AMANDA C (contact)

PROGRAM_OFFICER_NAME: OHAYON, JOAN M

PROJECT_TERMS: Academic Medical Centers;Acceleration;Adult;Area;Biological Markers;career;Child;Childhood;Clinical Data;Clinical Investigator;Clinical Research;clinical research site;clinical trial protocol;Clinical Trials;Clinical Trials Design;Clinical Trials Network;Collaborations;Data;data quality;data quality/integrity;Dedications;Development;Devices;Disease;Disease Marker;DNA Databases;Education;Educational Status;Enrollment;Environment;experience;Faculty;Foundations;Funding;Future;Gene therapy trial;Genetic;Genomics;Goals;Health;improved;Industry;innovation;Inpatients;Institution;Institutional Review Boards;Leadership;Link;Medical center;Medical Records;Mentorship;Modeling;Multicenter Trials;multidisciplinary;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;neurogenetics;neuroimaging;Neurologic;Neurology;Neurosciences;neurosurgery;next generation;novel;Outpatients;Participant;participant retention;patient oriented research;Patient Recruitments;Pediatrics;Pharmacologic Substance;Phase II Clinical Trials;Positioning Attribute;Principal Investigator;Privatization;protocol development;recruit;Research;Research Personnel;Resources;response;Sampling;Site;Students;therapeutic genome editing;Translational Research;Universities

PROJECT_TITLE: Vanderbilt Site for Network of Excellence in Neuroscience Clinical Trials


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Diabetes;Hematology

ORG_CITY: OMAHA

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Narrative Hemoglobin, a red blood cell protein that carries oxygen throughout the body, when glycated (modified by high glucose in the blood), is referred to HbA1c, and is used by clinicians as an overall picture of a diabetic patient’s ability to control their glucose over a 3-month period and as an indicator for future cardiovascular risks. The aim of the current proposal is to determine if hemoglobin expressed in arteries can be glycated like its counterpart in red blood cells, and if so, how modification of hemoglobin in arteries will affect the way blood vessels dilate and constrict in response to various stimuli in diabetes. This work has the potential to identify new markers of cardiovascular risk in patients with diabetes and may help in the development of new therapeutic approaches.

PI_NAMEs: BAGHER, POONEH  (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Acute;Adrenergic Agents;Affect;Amino Acids;Arteries;Binding;Binding Sites;Biological Availability;Blood;Blood flow;Blood Glucose;blood glucose regulation;Blood Pressure;Blood Vessels;Calcium;calcium indicator;cardiovascular risk factor;Cell Line;Chronic;constriction;cytochrome b5 reductase;Data;Development;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic patient;Diabetic Retinopathy;Elasticity;Endothelial Cells;Endothelium;Enzymes;Erythrocytes;Event;Exposure to;Extracellular Matrix Proteins;Feedback;Functional disorder;Future;Genetic;genetic approach;Glucose;glycation;Glycosylated Hemoglobin;Glycosylated hemoglobin A;Hemoglobin;Hypertension;Hypoxia;Impairment;improved;In Vitro;in vivo;Intermittent Claudication;knock-down;Knockout Mice;Measures;Mediating;Modification;monomer;mouse model;Mus;N-terminal;Nitric Oxide;Nitric Oxide Synthase;NOS3 gene;novel;novel marker;novel therapeutic intervention;Oxygen;Pathology;Pathway interactions;Patients;Peptides;pharmacologic;Pharmacological Treatment;Play;Predisposition;Process;Protein Isoforms;Proteins;Reaction;Regulation;response;Risk;Role;Site;Skeletal Muscle;Smooth Muscle Myocytes;Stimulus;Streptozocin;Structure;Structure of popliteal artery;Tamoxifen;Testing;Therapeutic;therapeutic target;Tissues;Valine;Vascular Diseases;vasoconstriction;Vasodilation;Vasomotor;Work;wound healing

PROJECT_TITLE: The role of hemoglobin alpha in diabetes-related vascular dysfunction

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Autoimmune Disease;Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention;Psoriasis

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative: Psoriasis, a common chronic inflammatory skin disease affecting approximately 2% of the population, is associated with increased cardiovascular (CV) risk. This study will test the hypothesis that tildrakizumab, an FDA approved therapy for psoriasis that blocks the Th17 pathway of inflammation, improves coronary flow reserve and cardiac mechanics in patients with psoriatic disease and enhanced CV risk, and mechanistically assess the cellular immunophenotype at the single cell level underlying these changes in coronary vasomotor function. Our proposed research may offer novel insights into the contributors of CV risk in psoriasis and provide data to support the development of strategies to prevent cardiovascular events by targeting inflammation.

PI_NAMEs: WEBER, BRITTANY NICOLE (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Acceleration;Address;Advisory Committees;Affect;Aftercare;Age;Anti-Inflammatory Agents;Arterial Fatty Streak;Atherosclerosis;Award;Blood flow;Blood Vessels;burden of illness;Cardiac;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular imaging;cardiovascular risk factor;Cardiovascular system;career;career development;Cells;Cellular biology;Cessation of life;chronic inflammatory skin;Classification;Clinical;clinical care;clinical risk;clinical translation;Clinical Trials;Coronary;Coronary Arteriosclerosis;Data;Dermatology;design;Development;Disease;Echocardiography;endothelial dysfunction;Endothelium;Epitopes;Event;Exposure to;FDA approved;Foundations;Functional disorder;Functional Imaging;functional improvement;Funding;Future;genetic signature;Goals;Health;Heart failure;heart imaging;Heterogeneity;High Prevalence;IL17 gene;Imaging Techniques;Immune;Immunologist;Immunology;Immunophenotyping;Impairment;improved;indexing;Inflammation;Inflammatory;insight;interleukin-23;Investigation;Left Ventricular Function;Link;Measures;Mechanics;Mediating;Mediator;Medicine;Mentors;Methods;Microvascular Dysfunction;Molecular Profiling;Monitor;Morphology;mortality;multimodality;Myocardial;Myocardial dysfunction;Myocardial Infarction;Myocardial Ischemia;Myocardial tissue;novel;Outcome;Pathway interactions;patient population;Patients;Perfusion;Peripheral Blood Mononuclear Cell;Physicians;Play;Population;Population Control;Positron-Emission Tomography;Prevalence;prevent;Prevention strategy;Prognosis;Program Development;Psoriasis;Psoriatic Arthritis;Relaxation;Research;Research Personnel;response;Rheumatology;Risk;Risk Factors;Role;Scientist;Severity of illness;sex risk;single cell analysis;single-cell RNA sequencing;skills;skin disorder;Solid;Stress;Structure;Symptoms;systemic inflammatory response;Techniques;Testing;Therapeutic Trials;Tissues;Training;transcriptome;Translations;vascular abnormality;Vascular Diseases;Vasodilator Agents;Vasomotor

PROJECT_TITLE: Advanced CV imaging and immunophenotyping to study coronary vascular health in psoriasis

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Burden of Illness;Coronaviruses;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: MERIDA

ORG_COUNTRY: MEXICO

ORG_FIPS: MX

ORG_NAME: AUTONOMOUS UNIVERSITY OF YUCATAN

PHR: PROJECT NARRATIVE Addressing the public health significance of SARS-CoV-2 requires a comprehensive analysis that includes genomics, phylodynamics and mathematical modeling of the epidemiological trends. Understanding the routes and mechanisms that lead to the emergence, seeding, and subsequent circulation of more transmissible or more pathogenic viral lineages will be crucial to guide local, national and international authorities in their response to COVID-19 pandemic.

PI_NAMEs: AYORA-TALAVERA, GUADALUPE  (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 2019-nCoV;Address;Age;Americas;Archives;authority;Automobile Driving;breakthrough infection;Cessation of life;Characteristics;Circulation;Climate;Clinical;comorbidity;Country;COVID-19;COVID-19 burden;COVID-19 mortality;COVID-19 pandemic;Data;data integration;Databases;Demography;Disease;Disease Outbreaks;Early identification;Effectiveness;emerging pathogen;epidemiologic data;epidemiological model;Epidemiological trend;Epidemiology;Event;fitness;Genetic;genetic variant;genomic data;genomic epidemiology;Genomics;Geography;Goals;Health;Immune;infection rate;influenzavirus;interest;International;Intervention;Laboratories;Latin America;mathematical model;Measures;Mexico;migration;Monitor;Mutation;Pathogenicity;Patients;Population;Population Dynamics;Process;Property;Prospective Studies;Public Health;public health intervention;Recording of previous events;Reporting;repository;Reproduction;response;Reverse Transcription;Route;Sampling;SARS-CoV-2 B.1.1.529;SARS-CoV-2 B.1.1.7;SARS-CoV-2 B.1.351;SARS-CoV-2 B.1.617.2;SARS-CoV-2 transmission;SARS-CoV-2 variant;Seasons;sex;Specimen;Speed;System;Time;tool;transmission process;Travel;Universities;Vaccination;Vaccinee;Vaccines;Variant;variants of concern;Viral;Viral Genome;viral transmission;virology;Virus;Work

PROJECT_TITLE: The impact of immune escape on the epidemiology and evolutionary dynamics of the COVID-19 pandemic in Yucatan, Mexico

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer

ORG_CITY: NEW YORK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative  The focus of the Weill Cornell Cancer Pharmacology Training Grant/Program is to train predoctoral students and PhD, MD, and MD/PhD postdoctoral fellows to perform research that will (a) use a variety of state-of-the-art experimental approaches to develop new drugs for cancer prevention and treatment, and (b) provide new knowledge about the mechanisms of action of existing drugs currently in use for cancer treatment. The ultimate goal is to translate this knowledge into new therapies for cancer that will be safer and more effective.

PI_NAMEs: GUDAS, LORRAINE J (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: cancer pharmacology

PROJECT_TITLE: Cancer Pharmacology

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Hematology;Infectious Diseases;Precision Medicine;Sepsis

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE The inner surface of all blood vessels is lined by a thick layer of sugars. During critical illnesses such as sepsis, this layer is damaged, causing organ failure and releasing sugars into the blood. In this proposal, we will determine if a rapid, inexpensive blood or urine test can be used to detect circulating sugars in critically ill patients, potentially allowing for early identification of patients at high risk of worsening disease.

PI_NAMEs: SCHMIDT, ERIC PETER (contact);SHAPIRO, NATHAN I

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Academic Medical Centers;Address;Animals;biobank;Biological;Biological Assay;Biological Markers;Blood;Blood Vessels;Boston;Brain;Caring;cell free DNA;Characteristics;Circulation;Clinical;clinical care;clinical decision-making;clinical research site;clinically relevant;cohort;Cohort Studies;Color;cost;Critical Care;Critical Illness;cross reactivity;Data;Detection;detection assay;dimethylmethylene blue;Disease;Early identification;Endothelium;Enzyme-Linked Immunosorbent Assay;Excretory function;Freezing;Functional disorder;Future;General Hospitals;Glycocalyx;Glycosaminoglycans;Health;high risk;Homeostasis;Hospitals;Hour;Human;Image;indexing;Injury;Interobserver Variability;intravital microscopy;Investigation;Israel;Kinetics;Laboratories;Liquid substance;Mass Spectrum Analysis;Massachusetts;Measurement;Measures;Medical center;Memory;Microcirculation;Microvascular Dysfunction;Neurocognitive;Organ failure;organ injury;Outcome;Pathogenesis;Patient Admission;Patient-Focused Outcomes;Patients;Penetration;Plasma;point of care;polysulfated glycosaminoglycan;precision medicine;preclinical study;predictive marker;prospective;Prospective Studies;protein biomarkers;Proteins;Proxy;rapid test;Reaction;risk stratification;Sampling;Sepsis;septic;septic patients;Severities;Severity of illness;sugar;Surface;Survivors;targeted treatment;Testing;Therapeutic Intervention;Thick;Time;Translational Research;urinary;Urine;Validation;vascular bed;Venous blood sampling;Visualization;Woman

PROJECT_TITLE: Optimization of a rapid assay to quantify circulating glycosaminoglycans and identify vascular endotypes of sepsis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-D(02)M]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Nutrition;Pancreatic Cancer;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE  Most pancreatic ductal adenocarcinomas have a dense, fibrotic, and hypo-vascular stroma, rendering them hypoxic, nutrient deprived, and chemoresistant. The overall goal of this project is to gain a better understanding of the stromal components – vasculature and cancer associated fibroblasts – by which pancreatic cancer cells acquire essential nutrients. The information gained from these studies will provide guidance for precision medicine-based approaches targeting these essential metabolic “supply lines” in pancreas cancer.

PI_NAMEs: SIMON, M. CELESTE;STANGER, BEN Z (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: Address;Angiogenesis Inhibitors;B-Lymphocytes;Biological;Blood Vessels;cancer cell;Cell division;Cells;Chemoresistance;Clinical;Clinical Trials;clinically relevant;cohort;coping;Data;Data Set;Desmoplastic;Development;Ecosystem;Endothelial Cells;Exhibits;Fibroblasts;Genetically Engineered Mouse;Geography;Goals;Heterogeneity;Human;human data;human tissue;Hypervascular;Hypoxia;Implant;improved;innovation;insight;Invaded;lipid metabolism;Lipids;Lymphatic;Malignant neoplasm of pancreas;Malignant Neoplasms;Metabolic;Microscopy;Modeling;Molecular;mouse model;Neighborhoods;neoplastic cell;Nutrient;Oxygen;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pathway interactions;patient subsets;precision medicine;Proteins;regional difference;response;Source;supply chain;Techniques;Therapeutic;tissue resource;treatment strategy;tumor;tumor heterogeneity;tumor microenvironment;Unsaturated Fatty Acids;Vascular Endothelial Cell;Vascular Endothelium

PROJECT_TITLE: Stromal and vascular inputs into pancreatic cancer tumor neighborhoods

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Palliative Care;Patient Safety;Physical Injury - Accidents and Adverse Effects

ORG_CITY: MADISON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Improving care for older adults with serious illness is a public health priority because 1) it affects large numbers of people, 2) it can reduce unwanted invasive treatments and improve quality of life and 3) there is public demand to improve end-of-life care delivery. This project aims to address this priority by testing an intervention—a communication tool plus clinician training in its use—designed to improve communication about prognosis and support clinicians and families of older adults with serious traumatic injury in the ICU. Given trends in the number of older people who are severely injured, the intervention proposed in this study could impact more than 500,000 older adults annually.

PI_NAMEs: SCHWARZE, MARGARET  (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Address;Admission activity;Affect;American College of Surgeons;Award;burnout;Businesses;care delivery;care outcomes;Caring;Cause of Death;Cessation of life;Clinical Trials;Cognitive;Collaborations;Communication;communication aid;Communication Tools;Conflict (Psychology);Data Collection;Decision Making;design;Distress;Educational process of instructing;Effectiveness;effectiveness study;effectiveness testing;Emergency Situation;end of life;end of life care;end-of-life communication;Evaluation;Event;experience;Family;Family member;family support;Feasibility Studies;Feeling hopeless;Force of Gravity;Frequencies;Future;Goals;Government;Healthcare;Healthcare Systems;Hospitals;implementation intervention;improved;injured;Injury;innovation;Intensive Care;Intensive Care Units;interpersonal conflict;Intervention;intervention effect;Length of Stay;Life;Measurement;Measures;Mediating;member;Military Personnel;Morals;mortality;mortality statistics;multidisciplinary;novel;older adult;older patient;Older Population;Operative Surgical Procedures;Outcome;Outcome Study;Patient Care;Patients;Persons;Pilot Projects;pilot test;Positioning Attribute;primary outcome;Procedures;Process;Professional Organizations;Prognosis;programs;Provider;public health priorities;Quality of life;Randomized;randomized, clinical trials;Recording of previous events;Reporting;Research;Risk;secondary outcome;severe injury;Site;support tools;Surgeon;surrogate decision maker;Testing;tool;Training;Translating;Trauma;trauma care;trauma centers;Trauma Research;Traumatic injury;treatment group;Treatment outcome;trend;Uncertainty;United States

PROJECT_TITLE: A Randomized Clinical Trial of Scenario Planning for Older Adults with Serious Injury

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ANN ARBOR

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The project is to understand the fundamental aspect of the origin, trafficking and functions of the progenitors for specialized early-acting lymphocytes called innate lymphoid cells. The outcomes will greatly enhance our understanding of how these cells in key peripheral tissues are established and maintained to ward off pathogens and regulate inflammatory and allergic responses. Moreover, the results are expected to provide novel strategies to harness and control these important immune cells.

PI_NAMEs: KIM, CHANG H (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: adaptive immune response;allergic response;Behavior;Blood Circulation;Bone Marrow;cell motility;Cell Proliferation;Cells;chronic inflammatory disease;circadian;Circadian Rhythms;Cues;Disease;Emigrations;graft vs host disease;Health;Homeostasis;Homing Behavior;IL18 gene;Immune;Immunity;Immunocompromised Host;Inflammation;Inflammatory;Inflammatory Response;insight;Investigation;Knowledge;life span;Lymphocyte;Lymphoid;Lymphoid Cell;Maintenance;Mediating;Metabolic;microbial;migration;Molecular;Natural Immunity;novel;novel strategies;Organ;Outcome;pathogen;Pathogenesis;Pathogenicity;Pattern;Peripheral;Population;Process;progenitor;receptor;Regulation;Reporting;Role;Signal Transduction;Site;stem cell function;stem cell population;stem cells;System;Testing;Therapeutic;Time;Tissues;trafficking;ward

PROJECT_TITLE: Mobilization and trafficking of central ILC progenitors

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Mental Health;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Traumatic Head and Spine Injury;Violence Against Women;Violence Research;Women's Health Research

PHR: PROJECT NARRATIVE Despite the high risk of brain injury among survivors of intimate partner violence, there are no standard guidelines for brain injury screening and referral in this group of women that can provide them with timely support and help mitigate the impact of brain injury. Using a participatory approach, we will examine how screening and referral of intimate partner violence-related brain injury can be effectively integrated into the workflow of community-based organizations serving intimate violence survivors. The public health impact will be an advanced scientific understanding of implementation strategies related to the secondary prevention of brain injury among community organizations serving survivors of intimate partner violence and this information will help inform future policies for timely screening, referral, and neurorehabilitation and ultimately reduce neurological damage in this population.

PI_NAMEs: RAJARAM, SHIREEN SHEELA (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Address;Adoption;Alzheimer's Disease;Anoxia;Anxiety;Brain;Brain Injuries;brain tissue;Cessation of life;Client;community based participatory approach;community engaged approach;community organizations;contextual factors;Data;Detection;Development;Dissemination and Implementation;Distress;Effectiveness;evidence base;experience;Face;Fatigue;Future;Goals;Guidelines;Head;Headache;Health;health care settings;high risk;Hypoxia;implementation process;implementation strategy;improved;Injury;Intervention;intimate partner violence;Knowledge;knowledge base;Maintenance;Memory;Mental Depression;Methods;Neck;Nervous System Trauma;Neurologic Deficit;neurological rehabilitation;novel;Outcome;Oxygen;Patients;Perception;Personal Satisfaction;Persons;Policies;poor health outcome;Population;Practical Robust Implementation and Sustainability Model;Process;Provider;Public Health;Quality of life;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recovery;Reporting;Risk;routine practice;routine screening;Scientific Advances and Accomplishments;screening;Screening Result;Secondary Prevention;Secondary to;Sleep;Suicide;Survivors;Symptoms;Testing;Trauma;Traumatic Brain Injury;tv watching;Violence;Vulnerable Populations;Woman;Women's Group

PROJECT_TITLE: Community-Based Organizations and Development of Implementation Strategies for Brain Injury Screening Resulting from Intimate Partner Violence

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Broadly neutralizing antibodies and therapeutic vaccines have demonstrated antiviral efficacy in HIV-1-infected humans and SIV/SHIV-infected rhesus macaques. However, the mechanisms underlying the efficacy of these interventions remain unknown. We propose to define mechanisms of efficacy of broadly neutralizing antibodies and therapeutic vaccines using a coordinated virologic, immunologic, and multi-omic approach with the goal of developing improved next generation HIV-1 cure strategies.

PI_NAMEs: BAROUCH, DAN H. (contact)

PROGRAM_OFFICER_NAME: SANDERS, BRIGITTE E

PROJECT_TERMS: animal resource;anti-viral efficacy;antiretroviral therapy;antiviral immunity;Basic Science;Biological;Biological Assay;Cellular Immunity;combinatorial;Computer Analysis;data integration;Data Set;Development;gastrointestinal;Goals;HIV-1;Human;Immune;Immune response;Immunologics;improved;Intervention Studies;lymph nodes;Lymphoid Tissue;Macaca mulatta;Mediating;Mucous Membrane;multiple omics;neutralizing antibody;next generation;nonhuman primate;Pathway interactions;Peripheral;Program Research Project Grants;programs;Research;Sampling Studies;simian human immunodeficiency virus;SIV;Testing;therapeutic vaccine;Tissues;Treatment Efficacy;vaccination strategy;vaccine efficacy;Vaccine Therapy;Vaccines;Viral;viral rebound;Viral reservoir

PROJECT_TITLE: Multi-Omics Analysis of Broadly Neutralizing Antibodies and Therapeutic Vaccination


NIH_SPENDING_CATS: Genetics

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Organisms employ diverse epigenetic mechanisms to facilitate acclimation and adaptation to environmental cues. Cephalopods and filamentous fungi recode the majority of their mRNAs through RNA editing, resulting in incredible protein diversity – how does RNA recoding support phenotypic plasticity, and is it a mechanism to facilitate genetic adaptation? This proposal will investigate how RNA recoding modulates the function of proteins involved in intracellular transport and DNA replication and repair to support phenotypic plasticity and adaptation.

PI_NAMEs: RANGAN, KAVITA  (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Acclimatization;Affect;Amino Acid Substitution;Aspergillus;Aspergillus nidulans;Bioinformatics;Biological Assay;Biology;career;career development;Carrier Proteins;Cell Physiology;cell type;Cephalopoda;Code;Codon Nucleotides;Complex;Cues;Data;Development;Development Plans;DNA;DNA biosynthesis;DNA Polymerase II;DNA Repair;DNA Repair Gene;DNA-Directed DNA Polymerase;Dynein ATPase;Early Endosome;Environment;Epigenetic Process;epigenetic regulation;experimental study;Exposure to;Fungal RNA;fungus;Genetic;genetic information;Genomics;Homologous Gene;Human;In Vitro;in vivo;interest;Intracellular Transport;Kinesin;Label;Maps;Mentors;Messenger RNA;Microscope;Microtubules;Mining;Molds;Molecular;Motility;Motor;Mutagenesis;mutant;Mutation;mutation assay;Neurospora;Neurospora crassa;novel;Oceans;Organism;Phase;Phenotype;Physiological;Polymerase;Primer Extension;programs;Property;protein aminoacid sequence;protein complex;protein function;Proteins;Publishing;Recombinants;Regulation;Reporter;Research;response;RNA;RNA Editing;Role;screening;Seawater;Secretory Vesicles;single molecule;Site;Squid;success;symposium;Temperature;Testing;Tissues;trafficking;Training;transcriptome sequencing;Variant;Work;Yeasts

PROJECT_TITLE: The functional and adaptive roles of RNA recoding


PROJECT_TERMS: Communication;Ensure;Financial Support;Goals;HIV vaccine;HIV-1;Logistics;meetings;multiple omics;National Institute of Allergy and Infectious Disease;neutralizing antibody;operation;Persons;Program Efficiency;Program Research Project Grants;programs;Research Personnel;Structure;symposium;timeline;Treatment Efficacy;Vaccine Therapy

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Genetics;HIV/AIDS;Human Genome;Immunization;Immunotherapy;Infectious Diseases;Vaccine Related

PI_NAMEs: JIANG, SIZUN  (contact)

PROJECT_TERMS: Affect;Antibodies;ATAC-seq;Biological;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chromatin;Clinical;Collaborations;Computer Analysis;Data;data acquisition;data sharing;design;Dissociation;DNA;empowerment;Ensure;Environment;experience;experimental study;Generations;genomic profiling;Genomics;Goals;HIV;Human Resources;Imaging technology;Immune response;Immunologics;Immunotherapeutic agent;In Situ;Infection;innovation;innovative technologies;Intervention;Investigation;Manuscripts;Measures;member;Methodology;Methods;Modeling;Molecular;Molecular Profiling;Multiomic Data;multiple omics;neutralizing antibody;pathogen;Peripheral Blood Mononuclear Cell;Phenotype;Population;Preparation;Proteins;Proteomics;Quality Control;Research Personnel;response;RNA;Sampling;Signal Pathway;simian human immunodeficiency virus;single cell analysis;single cell genomics;single cell sequencing;SIV;success;Surface Antigens;technology development;technology platform;Testing;Tissue Sample;Tissues;Transcript;transcriptome sequencing;transcriptomics;Treatment Efficacy;tumor-immune system interactions;Vaccination;Vaccine Therapy;Viral;Viral reservoir;Work

PROJECT_TITLE: Multi-Omics Core


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: HANOVER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE Invasive fungal infections in immune compromised patients such as those undergoing chemotherapy or high dose corticosteroid treatments are a major impediment to human health. Research in this proposal will uncover how the emerging fungal pathogen in this patient population, Aspergillus fumigatus, causes disease. Specifically, we have discovered that A. fumigatus isolate biofilm morphology is heterogenous and directly impacts host immunity and disease progression.

PI_NAMEs: CRAMER, ROBERT ANDREW (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Acute;Address;Adrenal Cortex Hormones;Allergic Bronchopulmonary Aspergillosis;Animal Model;anti-fungal agents;Antifungal Therapy;Architecture;Aspergillosis;Aspergillus;Aspergillus fumigatus;Biomass;Carbon;Cell Communication;Cells;chemotherapy;Chronic;Clinical;combat;Communities;Data;derepression;Development;Disease;Disease Outcome;Disease Progression;Dose;Drug resistance;Environment;Ethanol;Evolution;Exhibits;fitness;Foundations;Funding;Gene Cluster;Gene Family;gene function;Genes;Genetic;genetic analysis;Genomics;Glucose;Goals;Gossypium;Growth;Health;Heterogeneity;Hour;Human;human disease;Hypoxia;Immune;Immune system;Immunity;immunoregulation;in vivo;in vivo evaluation;Infection;innovation;insight;Knowledge;Laboratories;Leukocytes;lung injury;Mediating;Metabolic;Metabolism;Microbial Biofilms;Modeling;Molecular;Morphology;mouse model;Mycoses;neutrophil;Neutrophil Infiltration;novel;novel diagnostics;novel therapeutic intervention;Oxygen;pathogenic fungus;Pathway interactions;Patient Isolation;patient population;Patients;Pattern;Phenotype;Physiological;Physiology;Pilot Projects;Population;Predisposition;Property;Protein Analysis;Proteins;Research;resistant strain;Role;Site;Source;Study models;success;Suppressor Mutations;Tertiary Protein Structure;Testing;Therapeutic;tool;Virulence;Virulent;Work

PROJECT_TITLE: Evolution of Aspergillus fumigatus virulence


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;HIV/AIDS;Human Genome;Immunization;Immunotherapy;Infectious Diseases;Networking and Information Technology R&D (NITRD);Vaccine Related

PI_NAMEs: MA, QIN  (contact)

PROJECT_TERMS: Address;Algorithms;Architecture;ATAC-seq;Bioinformatics;Biological;Biological Assay;Biometry;Cell Communication;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clinical;Collaborations;computational pipelines;Computer Analysis;Computing Methodologies;Data;Data Analyses;data integration;data management;Data Set;data sharing;design;DNA;Ensure;experience;Experimental Designs;Flow Cytometry;Generations;Genes;genomic data;Goals;Hand;HIV;HIV Infections;In Situ;innovation;insight;Manuscripts;medical schools;member;Methodology;Methods;Modality;Modeling;Molecular;Morphology;Multiomic Data;multiple omics;neutralizing antibody;Ohio;Pathogenesis;Pattern;power analysis;Preparation;Proteins;Quality Control;Reporting;Reproducibility;Research;Research Personnel;Research Project Grants;Ribosomal RNA;RNA;Sample Size;Sampling;Serology;Services;single cell analysis;single cell ATAC-seq;single cell genomics;single-cell RNA sequencing;Statistical Data Interpretation;Statistical Methods;success;System;Testing;Tissues;tool;transcriptome sequencing;Treatment Efficacy;Universities;Vaccine Therapy;Variant;Viral reservoir;viral RNA;Visualization;Work

PROJECT_TITLE: Computational Core


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Biotechnology;Brain Disorders;Genetics;Immunotherapy;Multiple Sclerosis;Neurodegenerative;Neurosciences;Rheumatoid Arthritis

ORG_CITY: Auburn

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: AUBURN UNIVERSITY AT AUBURN

ORG_STATE: AL

PHR: Dysregulation of Th17 cells have been implicated in the pathogenesis of autoimmune diseases including Multiple Sclerosis, rheumatoid arthritis, and colitis. HIF-1α is a transcription factor that regulates metabolic changes in Th17 cells. We have found that the nuclear receptor REV-ERB may regulate HIF-1α, and propose to explore this interaction and subsequent effect of REV-ERB modulation in T-cells.

PI_NAMEs: GRIFFETT, KRISTINE  (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Adaptive Immune System;Affect;African American;American;Autoimmune Diseases;autoimmune pathogenesis;Binding;Biological Assay;Biological Response Modifier Therapy;cancer immunotherapy;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell Physiology;Cells;ChIP-seq;Chronic;Chronic Disease;Colitis;Complex;cost;cost effective treatment;Crohn's disease;cytokine;Data;Development;Disease;Disproportionately impacts women;drug discovery;Drug Targeting;Ensure;EP300 gene;Equilibrium;Exons;Experimental Autoimmune Encephalomyelitis;Feedback;Future;gene repression;Gene Targeting;Genes;Genetic Transcription;Genus Hippocampus;Glycolysis;graduate student;health care availability;Health Care Costs;health disparities in women;Hispanic Women;Human;IL17 gene;Immune;Inflammation;Inflammatory;insight;Insulin-Dependent Diabetes Mellitus;interest;Interleukins;Knockout Mice;Life;Ligand Binding;Ligands;Link;Luciferases;Mediating;Metabolic;Metabolic Pathway;Microbe;Multiple Sclerosis;Mus;Native Americans;novel;novel therapeutics;Nuclear Receptors;Pathogenicity;Patients;Physiological;Play;Population;Process;promoter;Promoter Regions;Protons;Psoriasis;recruit;reduce symptoms;Regulation;Reporting;Repression;Reproducibility of Results;Research Project Grants;Resistance;Response Elements;Rheumatoid Arthritis;Role;T cell regulation;T-Cell Activation;T-Lymphocyte;targeted treatment;Therapeutic;transcription factor;Transcriptional Activation;Transcriptional Regulation;United States;Work;Yin

PROJECT_TITLE: Investigating the link between REV-ERB and HIF-1a in Th17 cell function

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


PROJECT_TERMS: animal care;Animal Model;Animals;Blood specimen;Cataloging;Clinical;Complex;Data Analyses;Data Collection;Ensure;experience;Goals;HIV-1;Human Resources;in vivo;Infection;Infrastructure;Israel;Laboratories;Leadership;Logistics;Macaca mulatta;Medical center;multiple omics;neutralizing antibody;nonhuman primate;Positioning Attribute;Procedures;Program Research Project Grants;programs;Protocols documentation;Quality Control;Reagent;Research;Sampling;simian human immunodeficiency virus;SIV;Technical Expertise;Tissue Sample;Vaccine Therapy;vaccine trial

PROJECT_TITLE: NHP Core


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;HIV/AIDS;Human Genome;Immunization;Immunotherapy;Infectious Diseases;Vaccine Related

PROJECT_TERMS: anti-viral efficacy;Antibody Therapy;Cell surface;Cells;Cellular Immunity;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chromatin;Clinical;Clinical Trials;Computer Analysis;Data;Dose;Drug Kinetics;Effectiveness;gastrointestinal;Genetic Transcription;Genomics;HIV-1;Human;Immune response;Immunologics;In Situ;Individual;Infusion procedures;insight;Intervention Studies;lymph nodes;Lymphoid Tissue;Macaca;Macaca mulatta;Measures;Molecular Profiling;Mucous Membrane;Multiomic Data;multiple omics;neutralizing antibody;next generation;nonhuman primate;Participant;Phenotype;Property;protein biomarkers;Proteins;Proteomics;Reporting;Resistance;Resolution;simian human immunodeficiency virus;single cell ATAC-seq;single-cell RNA sequencing;Specimen;Testing;Therapeutic;Tissue Sample;Tissues;Transcript;transcriptomics;Vaccine Therapy;Vaccines;Viral;viral detection;viral DNA;Viral Physiology;viral rebound;Viral reservoir;viral RNA;Virus;Virus Replication

PROJECT_TITLE: Multi-Omics Correlates of Broadly Neutralizing Antibody Efficacy


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Prevention;Vaccine Related

PI_NAMEs: JUELG, BORIS DOMINIK (contact)

PROJECT_TERMS: Active Immunization;acute infection;Affect;Agonist;aluminum sulfate;Animals;Antigen-Antibody Complex;Antigens;cell growth;Clinical Research;combinatorial;Combined Vaccines;Computer Analysis;Control Groups;Data;gastrointestinal;Goals;HIV;HIV-1;Human;Immune;Immune response;Immunization;immunogenic;Immunologics;in vivo;Individual;insight;Interruption;Intervention;intervention effect;Intervention Studies;lymph nodes;lymphoid organ;Lymphoid Tissue;Macaca;Macaca mulatta;Mediating;mosaic;Mucous Membrane;Multiomic Data;multiple omics;neutralizing antibody;next generation;nonhuman primate;Passive Immunization;Peripheral;Property;Proteins;Regimen;Resolution;simian human immunodeficiency virus;SIV;Specimen;T cell response;T-Lymphocyte;Testing;therapeutic evaluation;therapeutic vaccine;Tissues;TLR7 gene;Vaccination;vaccination strategy;vaccine efficacy;vaccine strategy;Vaccine Therapy;vaccine trial;vaccine-induced immunity;Vaccines;Viral;Viral reservoir;Virus Latency;Work

PROJECT_TITLE: Multi-Omics Correlates of Therapeutic Vaccine Efficacy


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE (PUBLIC HEALTH RELEVANCE STATEMENT) Development of effective vaccines to prevent Clostridioides difficile infection (CDI), the most common healthcare-associated pathogen in the US, requires a deep understanding of the bacterial components that stimulate strong immune responses in humans. Through our proposed studies using an innovative plasmablast approach, we will identify these bacterial components and develop a panel of antibodies that target a variety of toxin and non-toxin antigens. We will thereby identify candidate antigens that will inform future immune-based therapies and vaccine strategies.

PI_NAMEs: KOCIOLEK, LARRY K (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Acute;acute infection;Address;Adult;Affect;Animal Model;Animals;Antibodies;Antibody Response;Antigen Presentation;Antigen Targeting;Antigens;Bacterial Infections;Binding;Biological Assay;candidate identification;Cell Culture Techniques;Cells;Child;Childhood;Classification;Clinical;clinical development;Clonal Expansion;Cloning;Clostridium difficile;Colitis;Communities;cytotoxicity;Data;Development;Diarrhea;Enzyme-Linked Immunosorbent Assay;Epitopes;experimental study;FDA approved;Feces;Flagellin;Future;genome sequencing;Goals;Health Expenditures;Healthcare;healthcare-associated infections;Human;Human Cloning;human monoclonal antibodies;Immune;Immune response;Immunization;Immunocompetent;immunogenicity;Immunologics;Immunoprecipitation;Immunotherapy;In Vitro;in vivo;Incidence;Infection;Infection prevention;infection risk;innovation;Investigation;Knowledge;Life;Membrane Proteins;Methods;Molecular Conformation;Monoclonal Antibodies;Morbidity - disease rate;mortality;Mucocutaneous Lymph Node Syndrome;Mus;novel;pathogen;Pathogenesis;Patients;Peptides;Peripheral;peripheral blood;Plasma Cells;Plasmablast;preclinical study;Preparation;prevent;Prevention;Prevention strategy;Proteins;Public Health;public health priorities;public health relevance;Recovery;Recurrence;recurrent infection;Resolution;response;Surface;tandem mass spectrometry;therapeutically effective;Toxin;Transgenic Mice;transmission process;Vaccination;vaccine strategy;Vaccines;Vibrio cholerae;Virus Diseases;Western Blotting;whole genome;Work

PROJECT_TITLE: Identification of the antigenic targets of the clonal antibody response to Clostridioides difficile infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDB-K(90)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Complementary and Integrative Health;Infectious Diseases;Natural Products;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: HILO

ORG_NAME: UNIVERSITY OF HAWAII AT HILO

ORG_STATE: HI

PHR: PROJECT NARRATIVE - PUBLIC HEALTH RELEVANCE STATEMENT Neuroangiostrongyliasis is a potentially lethal central nervous system parasitic infectious disease occurring in high incidence in Hawaii and other Pacific Islands, and is emerging in other tropical and subtropical regions, including significantly the southeastern US. However, there is no specific treatment for the disease. Thus, the proposed project has immense public health importance to the state of Hawaii and is of immediate relevance to the Asia-Pacific region, as well as the continental United States, where the range of A. cantonensis is expanding.

PI_NAMEs: CAO, SHUGENG  (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Adrenal Cortex Hormones;Albendazole;Angiostrongylus cantonensis;Anthelmintics;Antiparasitic Agents;Artemisinins;Asia;Bacteria;bioactive natural products;Biological Assay;Biological Sciences;blood-brain barrier penetration;blood-brain barrier permeabilization;Burn injury;Case Study;Central Nervous System;Central Nervous System Infections;Chemicals;Clinical Management;Clinical Treatment;Collection;Communicable Diseases;Cryoelectron Microscopy;Data;Development;Disease;Dose;drug discovery;efficacy evaluation;Emerging Communicable Diseases;emerging tropical infectious disease;endophytic fungi;ethnic diversity;Exhibits;experience;Filarial Elephantiases;fungus;Future;Goals;graduate student;Hawaii;Hawaiian;High Pressure Liquid Chromatography;high throughput screening;Human;human disease;Immobilization;in vivo evaluation;Incidence;Ingestion;innovation;Ivermectin;Larva;Lead;Libraries;Life Cycle Stages;Malaria;Mass Spectrum Analysis;Medical;medical schools;Medicine;Meningitis;Methods;Micro Electron Diffraction;microorganism;Modeling;Molecular Medicine;Monitor;Motility;Natural product discovery;Natural Product Drug;Natural Products;Natural Source;neglected tropical diseases;Nervous System Trauma;Neurologic;novel;novel drug class;novel strategies;Nuclear Magnetic Resonance;Ocular Onchocerciasis;Pacific Islands;Parasites;Parasitic Diseases;Parasitic nematode;Patients;Pharmaceutical Preparations;Pharmacy Schools;prednisolone;prevent;Public Health;public health relevance;Rattus;Recommendation;Recovery;Research;Research Infrastructure;response;Sampling;slug;Snails;socioeconomic disadvantage;Source;Specific qualifier value;Structure;Symptoms;System;Testing;therapeutically effective;undergraduate student;United States;Universities

PROJECT_TITLE: Antiparasitic Agent Discovery from Natural Products for the Treatment of a Globally Emerging Disease

STUDY_SECTION: DMPA

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology A Study Section [DMPA]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The studies proposed in this application will examine the landscape of microvascular endothelial cell phenotypes in obesity as well as investigate the role of HDAC9 in microvascular NOX1 expression and endothelial dysfunction in obesity. We will employ a novel AAV model of hyperphagia and obesity that can be easily combined with genetic models of endothelial lineage tracing and endothelial HDAC9 deletion to test the hypothesis that obesity upregulates HDAC9 to alter endothelial cell heterogeneity to favor loss of function, inflammatory phenotypes expressing NOX1. These studies will identify new mechanisms and paradigms by which endothelial dysfunction develops in obesity which may guide future therapeutic strategies to improve cardiovascular health.

PI_NAMEs: SELLERS, HUNTER GAGE (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Ablation;Animals;Aorta;Appetite Stimulants;Atherosclerosis;barrier to care;Blood Vessels;blood-brain barrier crossing;Body Weight decreased;Brain;Breeding;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;CDH5 gene;Cell Physiology;Chronic disability;Complex;cost effective;Data;Development;Diabetes Mellitus;Diet;Disease;Down-Regulation;Endothelial Cells;endothelial dysfunction;Endothelium;Epigenetic Process;Etiology;experimental study;Flow Cytometry;Functional disorder;Future;Gene Expression;Genetic;genetic approach;Genetic Models;Genomics;Genotype;Goals;HDAC9 gene;Heterogeneity;Human;human disease;Hyperglycemia;Hyperphagia;Hypertension;Impairment;improved;In Vitro;in vivo;Infertility;Inflammatory;Injections;insight;Intervention;Knock-out;Knockout Mice;Leptin;Life Expectancy;Link;loss of function;LoxP-flanked allele;Maps;Metabolic;Metabolism;Microcirculation;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;NADPH Oxidase 1;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Obese Mice;obese person;Obesity;obesogenic;Organ;overexpression;oxidant stress;Pattern;Peptides;Peripheral;Phenotype;Population;Predisposition;Role;Science;Shapes;Signal Transduction;single-cell RNA sequencing;Sorting;Stroke;Tamoxifen;Testing;Therapeutic;therapeutic target;Thinness;Time;transcriptomics;Up-Regulation;Vascular Diseases;Vascular Endothelial Cell;vascular endothelial dysfunction;Vascular Endothelium;Weight Gain;Writing

PROJECT_TITLE: Molecular Origins of Phenotypic Changes in the Obese Microvascular Endothelium


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: RALEIGH

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: Project Narrative: Cellular stress, DNA damage, pathogen insult, and immune mechanisms can activate molecular pathways that result in regulated cell death. The proposed research will enhance our understanding of how keratinocytes regulate cell death decisions in response to activation of the type 1 interferon response and DNA damage. Enhancing our understanding of the pathways that regulate cell death decisions in response to cellular stress is critical as misregulated cell death is linked to cancer, neurodegeneration and autoimmune diseases.

PI_NAMEs: HALL, JONATHAN RUSSELL (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Anti-viral Response;antimicrobial;Apoptosis;Apoptotic;Autoimmune Diseases;B-DNA;Biological;CASP3 gene;CASP8 gene;CCAAT-Enhancer-Binding Protein-beta;Cell Death;Cell Death Induction;Cellular Stress;Cessation of life;Communicable Diseases;Cutaneous;Data;Disease;DNA;DNA Damage;Double-Stranded RNA;Epidermis;experimental study;Genes;Genetically Engineered Mouse;Immune;in vivo;Induction of Apoptosis;Infection prevention;Infectious Skin Diseases;Inflammatory;Innate Immune Response;Interferon Type I;Interferon-beta;Interferons;keratinocyte;Laboratories;Link;Malignant Neoplasms;Mediating;Microbe;Modification;Molecular;Mus;Nerve Degeneration;new therapeutic target;novel;Nucleic Acids;Outcome;pathogen;Pathway interactions;Pattern recognition receptor;Play;Poly I-C;Proliferating;receptor;Receptor Signaling;Regulation;Repression;Research;response;RNA;Role;senescence;Skin;Skin Cancer;transcription factor;type I interferon receptor;Up-Regulation;Viral;Virus;Virus Diseases

PROJECT_TITLE: C/EBPβ Regulation of the Type 1 IFN Response; Sensitizing Keratinocytes to Direct Activators of Cytosolic PRRs and DNA Damage-Induced Cell Death

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Valley Fever

ORG_CITY: LOS ANGELES

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: The research proposed here extends on our previous research to develop scalable, rapid mass screening approaches for testing of SARS-CoV-2, the virus that causes COVID-19. Extending on genomic technologies, we will expand our sequencing-based approach to emerging pathogens such as monkey pox and Polio, develop agnostic testing approaches to rapidly screen for COVID19. This technology can inform public health measures lo rapidly identify outbreaks and control the spread of infection and can encompass both diagnosis and viral variant detection simultaneously.

PI_NAMEs: ARBOLEDA, VALERIE A;ESKIN, ELEAZAR  (contact)

PROJECT_TERMS: 2019-nCoV;Algorithmic Analysis;Area;Bar Codes;Biological Assay;Calibration;Cessation of life;CLIA certified;clinical development;clinical diagnostics;Clustered Regularly Interspaced Short Palindromic Repeats;Coccidioidomycosis;Collection;combinatorial;commensal bacteria;Communicable Diseases;Contact Tracing;Containment;cost;Coupled;COVID-19;COVID-19 detection;COVID-19 pandemic;COVID-19 screening;COVID-19 testing;current pandemic;desert fever;design;Detection;detection limit;detection method;Diagnosis;Disease;Disease Outbreaks;DNA;DNA sequencing;emerging pathogen;Excision;Failure;flexibility;future pandemic;Genomics;Goals;Health;Health Policy;high throughput screening;Hospitalization;Hour;Human;Human poliovirus;improved;indexing;Individual;Infection;innovation;International;Investments;Label;Laboratories;Light;Link;Masks;Mass Screening;Measures;Methodology;Methods;Molecular;Molecular Biology;Monkeypox;Nested PCR;next generation;next generation sequencing;novel;Nucleic Acids;pandemic disease;pandemic response;pathogen;pathogenic bacteria;pathogenic fungus;pathogenic virus;Patients;Persons;Poliomyelitis;Population;Probability;Process;Protocols documentation;Public Health;Quarantine;Rapid screening;Reaction;Readiness;Reagent;Research;research clinical testing;Reverse Transcriptase Polymerase Chain Reaction;Reverse Transcription;RNA;Running;saliva sample;Sampling;scale up;Series;Specimen;surveillance network;Swab;Symptoms;Technology;technology development;Test Result;Testing;Time;transcriptome sequencing;transmission process;Travel;Tube;Vaccination;Variant;variant detection;Viral;viral detection;Virus;Vision;Work

PROJECT_TITLE: Expanding Swabseq sequencing technology to enable readiness for emerging pathogens

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Dissemination and Implementation Research;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Primary Health Care;Social Determinants of Health;Telehealth

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The proposed two-phase study seeks to respond to the growing burden of adolescent mental health problems and urgent preventive service needs in Sub-Saharan African (SSA) countries by testing an integrated and potentially cost-efficient digital health intervention approach—the mHealth Toolkit for Screening & Empowering Lives of Youth (mSELY) in one SSA country, Kenya. The toolkit provides screening, tailored mental health literacy materials, and decision support for adolescents and/or their parents. We will study feasibility and effectiveness of the digital intervention in diverse community based organizations in Kenya.

PI_NAMEs: HUANG, KENG-YEN  (contact);KUMAR, MANASI

PROGRAM_OFFICER_NAME: CAMPBELL-ROSEN, HOLLY RENEE

PROJECT_TERMS: 8 year old;abuse neglect;abuse victim;Address;Adolescent;Adolescent Behavior;adolescent mental health;African;Anxiety;Automated Clinical Decision Support;Behavior;Behavioral;behavioral health;Big Data Methods;Canada;Caregivers;Child Mental Health;childhood adversity;Cognitive;Community Health Aides;community organizations;conduct problem;cost;cost effective;cost efficient;Country;Data;Data Science;design;digital;digital health;digital intervention;digital mental health;disability-adjusted life years;Disease;Economics;Effectiveness;effectiveness evaluation;effectiveness testing;eHealth;Emotional;empowerment;Environment;Environmental Risk Factor;Feasibility Studies;feasibility testing;Goals;Health;Health Educators;health literacy;Health Professional;Health Promotion;Health Services Research;Health system;health training;implementation outcomes;implementation research;improved;infancy;innovation;Institution;Intervention;Intervention Studies;Kenya;literacy;low and middle-income countries;meetings;Mental Depression;Mental disorders;Mental Health;Mental health promotion;Mental Health Services;Methodology;mHealth;mhealth interventions;Modality;Modeling;National Institute of Mental Health;Neurologic;novel;Outcome;Parents;peer;personalized care;personalized health care;Phase;Population;pregnant teen;prevent;Prevention;Preventive;preventive intervention;Preventive service;Process;Psyche structure;Public Health;Randomized, Controlled Trials;rapid growth;Research;Research Domain Criteria;Research Personnel;Resources;Risk;screening;Screening Result;self help;Self Perception;service gap;Services;skills;social;Technology;Testing;theories;therapy development;tool;Training;trial design;Uganda;United States National Institutes of Health;usability;user centered design;Workforce Development;years of life lost;Youth

PROJECT_TITLE: Implementing a Digital Adolescent Behavioral Health Screening, Literacy, and Low-Intensity Intervention for Common Adolescent Mental Health Problems in Kenya


NIH_SPENDING_CATS: Cancer;Genetics

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative  Replication Protein A coordinates all DNA metabolic processes including DNA replication,  repair, and recombination. Here, the role of chaperone-like proteins in regulating RPA are  dissected. These proteins are important in controlling genomic integrity and cancer-avoidance.

PI_NAMEs: KUPPA, SAHITI  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Affinity;Apoptosis;Base Sequence;Binding;Binding Proteins;Biochemical;biological adaptation to stress;Biophysics;BRCA1 gene;BRCA2 gene;Breast;cancer cell;carcinogenesis;career;Cell Cycle;Cell Cycle Arrest;Cell Cycle Regulation;Cell Death Induction;Cell Nucleus;Cell Signaling Process;Cells;Cervix Neoplasms;Chromosome Breakage;Clinical;Colorectal;Complex;Cryoelectron Microscopy;Cytoplasm;Defect;Dissociation;DNA;DNA Binding;DNA biosynthesis;DNA Damage;DNA metabolism;DNA Repair;DNA Repair Gene;DNA-Binding Proteins;Doctor of Philosophy;Eukaryota;Filament;Genes;Genetic;Genetic Recombination;genome integrity;Genomic Instability;Goals;Hela Cells;Homologous Gene;Human;Importins;inhibitor;inhibitor therapy;insight;Investigation;knock-down;Knowledge;Laboratories;Lesion;Malignant Neoplasms;Medulloblastoma;Metabolism;Modeling;Molecular Chaperones;Molecular Conformation;Mutation;novel;Nuclear;Nuclear Import;Nuclear Pore Complex;Nucleoproteins;Organism;Orthologous Gene;PALB2 gene;Pancreas;Phase;Phenotype;Phosphotransferases;Post-Translational Protein Processing;Postdoctoral Fellow;preservation;prevent;Process;Prostate;Protein Binding Domain;protein function;Protein Isoforms;Proteins;RAD52 gene;recruit;Regulation;repaired;replication factor A;replication stress;Research;Research Project Grants;response;restraint;Role;Saccharomyces cerevisiae;Signal Transduction;Single-Stranded DNA;Site;skills;small molecule;Stomach;Structure;Therapeutic;therapeutic target;tool;Training;tumor;Work

PROJECT_TITLE: Role of nuclear chaperones in genomic instability and carcinogenesis


NIH_SPENDING_CATS: Cancer;Hematology;Neurodegenerative;Neurosciences;Orphan Drug;Peripheral Neuropathy;Prevention;Rare Diseases

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative The microtubule-binding agent vincristine is among the most effective and widely prescribed anticancer agents, but its clinical use is associated with dose-limiting damage to peripheral neurons (neurotoxicity). Using unique genetic mouse models, we found that acute and chronic forms of neurotoxicity caused by vincristine are dependent on an uptake process in neurons that is mediated by the transporter OATP1B2 (in humans, OATP1B3). The proposed studies are a logical continuation of our mechanistic studies, and will directly test the hypothesis that targeted interference of OATP1B2 and OATP1B3 with pharmacological inhibitors can mitigate the incidence and severity of this debilitating side effect without affecting the agent’s anticancer properties.

PI_NAMEs: BAKER, SHARYN D;HU, SHUIYING  (contact);PETERSON, BLAKE

PROGRAM_OFFICER_NAME: ALTSHULER, RACHEL DINA

PROJECT_TERMS: access restrictions;Acute;Acute leukemia;acute leukemia cell;Adult;Affect;alpha Tocopherol;anti-cancer;Antineoplastic Agents;Binding;Biological Markers;biomarker driven;biomarker performance;Cell Line;Childhood Leukemia;Chronic;Circulation;Clinical;clinical implementation;combinatorial;Combined Modality Therapy;companion diagnostics;cytotoxic;Data;Dependence;Disease;Dose;Dose Limiting;Drug Kinetics;Drug Prescriptions;efficacy evaluation;Etiology;Event;Experimental Models;FDA approved;Future;future implementation;Genetic;Goals;Human;Image;improved;In Vitro;in vivo;in vivo evaluation;Incidence;inhibitor;insight;Intervention;Investigation;Kyocristine;Lead;leukemia;Leukemic Cell;Libraries;Link;LYN gene;Malignant - descriptor;Measures;Mediating;metabolomics;Microtubules;Modeling;mouse model;Mus;neuronal transport;Neurons;neuroprotection;neurotoxicity;novel;OATP Transporters;Oncology;Outcome;overexpression;Pathway interactions;Peripheral;Peripheral Nerves;Peripheral Nervous System Diseases;pharmacologic;Phosphotransferases;Phylogenetic Analysis;Plasma;preservation;prevent;Prevention strategy;Preventive treatment;Process;Property;Proteomics;Quality of life;Regimen;Rifampin;Safety;Sampling;Schedule;Severities;side effect;Solid Neoplasm;specific biomarkers;Specificity;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Spinal Ganglia;Testing;Therapeutic;Time;Toxicokinetics;Treatment Protocols;Tyrosine Kinase Inhibitor;Tyrosine Phosphorylation;uptake;Validation;validation studies;Vinca Alkaloids;Vincristine;Vitamin E;Wild Type Mouse;Work;Xenobiotics

PROJECT_TITLE: Targeting neuronal transport to ameliorate vincristine neurotoxicity

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Prevention;Substance Misuse;Substance Misuse Prevention

ORG_CITY: TEMPE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative Despite clear and convincing evidence for the efficacy of preventive interventions in preventing substance use and abuse (SU/A), the public health impact of these programs has been limited by inadequate uptake in community settings. We respond to this public health need by training pre-doctoral and post-doctoral researchers in the implementation science agenda that is needed to reduce the research-practice gap in SU/A prevention.

PI_NAMEs: BERKEL, CADY ;GONZALES, NANCY A. (contact)

PROGRAM_OFFICER_NAME: GOLDSTEIN, AMY B

PROJECT_TERMS: drug abuse prevention;Research;Research Training

PROJECT_TITLE: Research training in drug abuse prevention: closing the research-practice gap


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Rare Diseases

ORG_CITY: MISSOURI CITY

ORG_NAME: GENEIAL LLC

ORG_STATE: TX

PHR: Narrative Widespread access to analysis-ready patient data and engagement with patient communities are arguably the most significant bottlenecks for advancing research and therapeutic development for genetic disorders. We address these bottlenecks by facilitating the development of a privacy-preserving rare disease community engagement platform and universal registry, emphasizing FAIR principles (findability, accessibility, interoperability, reuse). This tool will accelerate widespread, compliant, and secure sharing of existing data, and catalyze investment in generation of new rare disease datasets.

PI_NAMEs: HANSEN, ADAM WESLEY (contact)

PROGRAM_OFFICER_NAME: RIDER, RENEE ANNE

PROJECT_TERMS: Acceleration;Address;Advocacy;Affect;Algorithms;Childhood;Clinical;Clinical Research;Clinical Trials;Collection;Communities;community engagement;community setting;Complement;Computer software;cost;cryptography;dashboard;Data;Data Aggregation;Data Collection;data exchange;data management;data privacy;data registry;Data Set;data sharing;Databases;design;Development;Diagnosis;Diagnostic;Disease;disease registry;encryption;Ensure;FAIR principles;Family;FDA approved;Future;Generations;Genes;Genetic;Genetic Diseases;genomic data;Genomic medicine;Genomics;Growth;Health;health data;Health Insurance Portability and Accountability Act;Healthcare;Healthcare Systems;Incentives;Individual;individual patient;Industry;Informed Consent;Infrastructure;innovation;Internet;Investments;Laboratories;Libraries;Manufacturer;Mendelian disorder;migration;Mission;open source;Ownership;Patient Recruitments;Patients;Performance;Pharmacologic Substance;Phase;Phenotype;phenotypic data;population health;precision genomic medicine;preservation;prevent;Privacy;privacy preservation;Privatization;Process;Rare Diseases;recruit;Registries;Research;research and development;Research Contracts;Research Personnel;Rights;search engine;Secure;Security;social media;Structure;Syndrome;System;Technology;Testing;Therapeutic;therapeutic development;Time;tool;Translations;user-friendly;web app;web platform

PROJECT_TITLE: Privacy-Preserving Connectivity for Rare-Disease Patients


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Services;Infectious Diseases;Social Determinants of Health;Substance Misuse

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: 8. PROJECT NARRATIVE People who inject drugs (PWID) are at high risk for HIV infection and experience poorer HIV treatment outcomes than other groups, particularly in low and middle income countries. We propose to rigorously assess three interventions that have the potential to improve HIV treatment outcomes among PWID in India.

PI_NAMEs: LUCAS, GREGORY M (contact);MEHTA, SHRUTI H

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: Address;Adoption;Africa;African;arm;Caring;Cities;Clinic;Communities;community based care;Continuity of Patient Care;cost;cost effectiveness;Cost Effectiveness Analysis;Country;Data;Decentralization;Dedications;design;Diagnosis;Effectiveness;effectiveness/implementation study;eligible participant;Epidemic;Evaluation;Evidence based intervention;experience;follow-up;Foundations;Government;Health;Health Policy;high risk;HIV;HIV Infections;HIV Seropositivity;Human immunodeficiency virus test;implementation facilitators;implementation science;improved;Incidence;Income;India;Individual;Injecting drug user;Injections;insight;integrated care;Intervention;intervention cost;intervention effect;Link;low and middle-income countries;Modeling;motivational enhancement therapy;Needle Sharing;novel;Opioid;opioid use;opioid user;Opium;Pathway interactions;patient navigation;patient navigator;Persons;Pharmaceutical Preparations;Policies;Population;Prevalence;Price;primary outcome;Production;psychosocial;Publishing;Randomized;randomized trial;Randomized, Controlled Trials;recruit;Respondent;response;Sampling;scale up;Site;skills;Social Network;System;Testing;testing uptake;Treatment outcome;Viral;Visit;Work

PROJECT_TITLE: PWID Opportunities to Improve TrEat and Retain (POINTER)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Mental Health;Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Nonhuman primates (NHPs) are critical for investigating the neural basis of cognition and mechanisms of diseases. However, we lack the tools to monitor and manipulate cell type-specific neural circuits in NHPs. Here, we will use an innovative approach to simultaneously classify cell types and create a genetic toolbox to manipulate NHP neural circuits.

PI_NAMEs: STAUFFER, WILLIAM RICHARD (contact)

PROGRAM_OFFICER_NAME: KIM, DOUGLAS SUN-IL

PROJECT_TERMS: adeno-associated viral vector;Adult;Anatomy;Bar Codes;Behavior;Behavioral;Brain;brain cell;Brain region;Breeding;Capsid;cell type;Cells;Classification;Clinical Trials;Code;Cognition;Cognitive;Complex;Consensus;Corpus striatum structure;cost;Data Set;Databases;Decision Making;Dependovirus;Development;dimension reduction;Disease;DNA;Dopamine Receptor;dopaminergic neuron;Engineering;Enhancers;Equipment and supply inventories;Evolution;experimental study;Foundations;functional restoration;Gene Delivery;Gene Expression;Gene Expression Profile;Gene Modified;gene therapy clinical trial;Gene Transfer Techniques;Genetic;Genetic Markers;Genetic Transcription;Genomics;Germ Lines;Goals;high throughput screening;Human;human disease;Individual;innovation;Investigation;Learning;Libraries;Macaca;Macaca mulatta;Maps;Mediating;Mental disorders;Methods;Midbrain structure;minimally invasive;Modeling;Modification;Monitor;Monkeys;Moods;Motor Cortex;multidisciplinary;Mus;Mutate;Nervous System Disorder;neural;neural circuit;Neuroanatomy;neuronal circuitry;Neurons;Neurosciences;nonhuman primate;Opsin;optogenetics;Outcome;Persons;Photophobia;Physiological;Prefrontal Cortex;Primates;promoter;Property;public database;reference genome;Regulatory Element;Retina;Retinal Degeneration;Retinal Ganglion Cells;Retinal gene therapy;Rewards;Role;single-cell RNA sequencing;Specificity;Structure;synthetic biology;System;Thalamic structure;Therapeutic;therapeutic gene;therapeutic transgene;tool;transcriptome;transcriptomics;transgene delivery;transgene expression;Tropism;Tyrosine 3-Monooxygenase;Update;Validation;validation studies;Variant;vector;Viral Vector;Vision;visual processing

PROJECT_TITLE: A Massive Library of AAVs to Target Transcriptionally-Defined Primate Cell Types


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative Fetal weight estimation, or the assessment of antenatal fetal weight for the purposes of growth tracking, labor planning, and management, is a critical component of safe prenatal care. Estimation of fetal weight, typically accomplished using ultrasound-derived measurements, is often inaccurate with up to 15% error for newborns of anticipated normal weight and up to 40% for newborns above 4,000 grams at birth. Our goal is to develop an image analysis algorithm to more accurately estimate fetal weight in the late third trimester of pregnancy.

PI_NAMEs: DREISBACH, CAITLIN  (contact)

PROGRAM_OFFICER_NAME: BOWEN, MARY ELIZABETH

PROJECT_TERMS: 37 weeks gestation;Abdomen;Agreement;Algorithmic Analysis;Algorithms;Anatomy;antenatal;Award;Biometry;Birth;Birth Certificates;Birth Weight;Blinded;Body mass index;breast density;Cardiology;career;career development;Cesarean section;Characteristics;Clinical;Clinical assessments;clinical care;clinical decision-making;computer science;computing resources;convolutional neural network;Data;Data Science;Decision Making;Detection;Development;Diagnosis;Diameter;Discipline of Nursing;Discipline of obstetrics;effectiveness testing;Environment;Eye diseases;Femur;fetal;Fetal Weight;Fingers;Future;Gestational Age;Goals;Growth;Head circumference;Height;Hospitals;Image;Image Analysis;improved;Infant;Infant Development;Information Systems;Interdisciplinary Study;Intervention;Learning;Length;Manuals;Maternal-fetal medicine;Measurement;Medicine;Mentored Research Scientist Development Award;Mentors;Mentorship;Methods;Midwife;multimodality;National Institute of Nursing Research;neonate;neural network;neural network algorithm;Neural Network Simulation;neurodevelopment;Newborn Infant;Nurses;Nursing Assessment;Observational Study;Operative Surgical Procedures;Overweight;Palpation;Parietal;Participant;Patients;Pattern Recognition;Perinatal;Personal Satisfaction;Physical Examination;Physicians;Placenta;Policies;policy implication;Practice Guidelines;Pregnancy;Pregnant Women;Prenatal care;prospective;Provider;Radiology Specialty;Research;Research Personnel;research study;Role;School Nursing;Signal Transduction;skill acquisition;skills;Specificity;success;Technology;Third Pregnancy Trimester;Time;tool;Training;Translations;tumor;Ultrasonography;ultrasound;United States;Universities;Uterus;Weight;Woman;Women's Health

PROJECT_TITLE: Neural Network Approach to Estimate Fetal Weight in the Late Third Trimester of Pregnancy

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(83)]


ADMINISTERING_IC: DK

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Obesity

ORG_CITY: NEW YORK

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: In modern times, excess calorie dense foods, sedentary lifestyle, and thermal comfort have contributed to an overexpansion of white fat and a paucity of brown fat, resulting in a dramatic increase in the prevalence of obesity, type 2 diabetes, and associated diseases. White and brown adipocytes have important secretory functions, but the full complement of mediators that can be secreted by fat cells and their underlying mechanism of action remain unknown. The goal of this collaborative, interdisciplinary team research proposal is to employ novel technologies to create an encyclopedia of the adipocyte secretome and to elucidate the function of novel mediators, providing a valuable resource for the field and generating biological insights that could facilitate the development of new therapies for obesity, type 2 diabetes, and metabolic diseases.

PI_NAMEs: CHAIT, BRIAN T;COHEN, PAUL  (contact);FENYO, DAVID ;SAGHATELIAN, ALAN

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Abdomen;Address;Adipocytes;Adipose tissue;Anti-diabetic Drugs;Area;Bioenergetics;Biological;Biological Markers;Biological Process;Biology;Biopsy;Blood;Brown Fat;Calories;Cell secretion;cell type;Chemicals;Complement;Data;Development;Diabetes Mellitus;Discipline;Disease;Encyclopedias;Fatty acid glycerol esters;Female;Food;Goals;Health;Homeostasis;Human;human subject;In Vitro;in vivo;innovation;insight;Insulin;Insulin Resistance;Investigation;Knowledge;life span;Link;male;Mass Spectrum Analysis;Mediator;member;Metabolic Diseases;Metabolism;Methodology;Methods;Mission;Modernization;Molecular;Molecular Target;mouse model;Mouse Strains;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;new technology;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Nutritional;Obesity;obesity treatment;Organ;Outcome;Pathogenesis;Pathologic;Physiological;Physiology;Play;polypeptide;Prevalence;Property;Protein Secretion;Proteins;Research Personnel;Research Project Grants;Research Proposals;Resistance;Resources;response;Role;Secretory Cell;sedentary lifestyle;Signal Transduction;Signaling Molecule;Site;small molecule;Source;Stress;subcutaneous;System;Techniques;Technology;Testing;Therapeutic;thermal stress;Tissues;tool;Triglycerides;Type 2 diabetic;Visceral

PROJECT_TITLE: An Encyclopedia of the Adipose Tissue Secretome to Identify Mediators of Health and Disease


ADMINISTERING_IC: ES

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: HUNTSVILLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: SAM HOUSTON STATE UNIVERSITY

PHR: PROJECT NARRATIVE Children in low and middle-income countries (LMIC) are at high risk of neurobehavioral (NB) abnormalities from exposure to toxic metals such as arsenic, lead, manganese, and cadmium, which potentially from their thyroid disrupting properties, are known to impede normal brain development. In Bangladesh, research studies on NB impact of metal co-exposure and the underlying mechanisms are lacking due to inadequate brain research infrastructure. This project aims to improve neuro-epidemiological research capacity of Bangladeshi scientists by providing training on epidemiological, biostatistical, and neurocognitive research methodology both in-country and in the U.S. so that they can apply the skills in examining child development and the potential mechanisms of mixed-metal neurotoxicity.

PI_NAMEs: KHAN, KHALID M. (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: 2 year old;Accounting;Address;Adolescence;Adolescent;adolescent health;Affect;Age;Antibodies;Applied Skills;Area;Arsenic;Bangladesh;Bangladeshi;Behavior assessment;Behavioral Research;Biological Markers;Biometry;Blood;Blood specimen;Brain;brain health;brain research;Cadmium;career;Child;Child Development;Childhood;Collaborations;college;Country;Data;Data Analyses;Development;diarrheal disease;disability-adjusted life years;early pregnancy;Economic Development;Economics;Education;Educational workshop;Environmental Pollutants;Environmental Risk Factor;epidemiologic data;Epidemiologist;Epidemiology;epidemiology study;Etiology;Evaluation;Exposure to;Faculty;First Pregnancy Trimester;Goals;Health;high risk;Impairment;improved;Individual;Infant;international center;Iodide Peroxidase;Iodine;Iowa;Knowledge;Laboratories;Lead;Life;Link;Longitudinal cohort study;low and middle-income countries;Manganese;Manuscripts;maternal serum;Measures;Mediating;Medical;Medicine;Metal exposure;Metals;Modeling;Mothers;Nervous System Disorder;neurobehavioral;Neurocognitive;Neurocognitive Deficit;neurodevelopment;Neuroepidemiology;neuroimaging;neurotoxicity;novel;Outcome;Performance;Persons;Phase;Population;prenatal;Preparation;programs;Property;Public Health;recruit;Research;Research Infrastructure;Research Institute;Research Methodology;Research Personnel;research study;Risk;Rural;rural area;Scientist;Serum;skills;Social Development;Standardization;symposium;System;systems research;Testing;Thyroglobulin antibody;Thyroid Diseases;thyroid disruption;Thyroid Hormones;Thyrotropin;Thyroxine;Toddler;tool;Toxic effect;toxic metal;Training;Triiodothyronine;Universities;urinary;virtual;webinar;Writing

PROJECT_TITLE: Building Capacity to study mixed metal-induced neurotoxicity in rural Bangladeshi children-A1


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Mental Health;Mental Illness;Psychosis;Schizophrenia;Serious Mental Illness

ORG_STATE: CA

PHR: Project Narrative The enduring deficits in neurocognition, social cognition, and emotion and associated negative symptoms have been shown to be the largest contributors to everyday work and social impairment in schizophrenia and other psychotic disorders. We need to understand how these factors impact outcomes, to develop and evaluate improved strategies for targeting these mediators of outcome, and to optimize our interventions to improve clinical and functional outcome. Thus, it is of vital national health relevance to train additional researchers to focus on clinical research on psychotic disorders, including experimental therapeutic approaches to targeting mechanisms and improving the efficacy of our interventions.

PI_NAMEs: NUECHTERLEIN, KEITH H (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TITLE: Clinical Research Training in Schizophrenia and Other Psychoses


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: MATHER

ORG_NAME: VA NORTHERN CALIFORNIA HEALTH CARE SYS

PHR: RELEVANCE OF THE PROPOSED RESEARCH TO VETERANS’ HEALTH: VA patients with recurrent prostate cancer (CaP), who have developed resistance to androgen deprivation therapy (ADT), are further treated with chemotherapy (docetaxel) but mostly with 2nd generation anti-androgens: abiraterone acetate+prednisone or enzalutamide, then switched to the opposite treatment when patients develop resistance to one. Recent publications indicate that post-ABI castration-resistant prostate cancer (CRPC) patients significantly benefit from docetaxel, though for a limited time. Our goal is to find ways to prolong the efficacy of docetaxel in post-ABI CRPC patients being treated at the VA. We propose the use of a drug candidate that specifically targets galectin-1, which plays important roles in tumor transformation, tumor cell proliferation, migration, survival and drug resistance. This compound represents a novel class of anti-cancer drug, and its successful development will greatly impact future therapies against CRPC at the VA.

PI_NAMEs: GHOSH, PARAMITA M. (contact)

PROJECT_TERMS: ABCB1 gene;abiraterone;Acetates;Affect;Alternative Splicing;Androgen Antagonists;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Antineoplastic Agents;benzimidazole;Binding;Biopsy;Cancer Patient;Castration;Cell Adhesion;cell growth;Cell Line;Cell Nucleus;Cell Proliferation;Cells;chemotherapy;comparative efficacy;CYP17A1 gene;cytotoxic;Data;Development;docetaxel;drug candidate;Drug resistance;enzalutamide;Future;Galectin 1;Generations;Goals;Health;inhibitor;Invaded;Ligand Binding Domain;Luteinizing Hormone-releasing Hormone Agonist;Malignant neoplasm of prostate;Mediating;Microtubule Stabilization;Microtubules;migration;Modeling;Multi-Drug Resistance;neoplastic cell;novel;Nuclear;Nuclear Envelope;Nuclear Import;Nuclear Pore;Nuclear Pore Complex;Nuclear Translocation;patient derived xenograft model;patient response;Patients;Pharmaceutical Preparations;Play;Prednisone;prevent;prostate cancer cell line;prostate cancer model;Protocols documentation;Publications;Recommendation;Recurrence;Regulation;Reporting;Research;Resistance;Resistance development;response;RNA Splicing;Role;Serum;Specific qualifier value;STAT3 gene;Testing;Time;treatment duration;treatment pattern;tumor;Tumor-Derived;Variant;Veterans;Veterans Health Administration

PROJECT_TITLE: Target, Function and Mechanism of LLS30 in Castration Resistant Prostate Cancer