PI_NAMEs: WATKINS, SIMON C (contact)

PROJECT_TERMS: Address;Algorithms;animal imaging;Animals;anti-tumor agent;Award;Biological Process;Budgets;Cancer Center;Cancer Center Support Grant;cancer therapy;cell fixing;Cell Therapy;Cells;cellular development;cellular imaging;cellular transduction;Communities;Complex;Computer Assisted;computer infrastructure;Computer software;Computers;Confocal Microscopy;Data;Data Analyses;data infrastructure;design;Development;Effector Cell;Electron Microscope;Electron Microscopy;equipment acquisition;Event;Experimental Designs;experimental study;Faculty;Fluorescence;Fluorescence Microscopy;Fluorescence Resonance Energy Transfer;Funding;gene therapy;Goals;Hour;Image;Image Analysis;imaging facilities;imaging system;Immune;In Situ;instrument;instrumentation;Investigation;Light;light microscopy;light transmission;Lighting;live cell imaging;live cell microscopy;Maintenance;Malignant Neoplasms;Measures;medical specialties;member;Messenger RNA;Methodology;Methods;Microinjections;Microscope;Microscopic;Microscopy;Modernization;Molecular;Morphology;multi-photon;multiphoton imaging;Optics;petabyte;pharmacologic;Process;programs;Proteins;Publications;ratiometric;reconstruction;recruit;Research;Research Personnel;Resolution;Resources;Sampling;Scanning;Scanning Electron Microscopy;Scientist;single molecule;Structure;superresolution microscopy;System;Techniques;Technology;Tissue imaging;Tissues;Training;Transmission Electron Microscopy;tumor;Tumor Burden;tumor microenvironment;ultra high resolution;United States National Institutes of Health;Vertebral column

PROJECT_TITLE: Cell and Tissue Imaging Facility


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Social Determinants of Health

ORG_CITY: LA JOLLA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Narrative The UC San Diego Faculty Development Program in Infectious Diseases RAPID will provide underrepresented early career academics with effective mentorship to successfully develop critical academic skills to enhance their research progress and success in obtaining extramural funding. The overall goal of the RAPID is to increase the diversity of the biomedical workforce.

PI_NAMEs: REZNIK, VIVIAN ;TREJO, JOANN  (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Academic skills;Acceleration;Affect;African American population;Alaska Native;American;Area;Award;base;Biomedical Research;California;career;career development;Career Mobility;Categories;caucasian American;Censuses;Child;Chronic Hepatitis C;Client satisfaction;Clinical Research;cohort;Collaborations;Communicable Diseases;Communication;Data;Development;Diagnosis;disability;disabled;Disparity;early-career faculty;Education;ethnic minority;ethnic minority population;Ethnic Origin;Ethnic Population;evidence base;experience;Extramural Activities;Faculty;faculty research;Fellowship Program;Fostering;Funding;General Population;Goals;Gonorrhea;Grant;health disparity populations;Hepatitis C;Hepatitis C Acquisition;Hepatitis C virus;Hispanic Populations;HIV;HIV diagnosis;Home;Immersion;improved;Individual;Infectious Diseases Research;Influenza vaccination;innovation;Institution;interest;K-Series Research Career Programs;Knowledge;Latinx;marginalization;medical schools;member;Mentors;Mentorship;Minority Groups;National Institute of Allergy and Infectious Disease;Native Americans;neonatal sepsis;Not Hispanic or Latino;parity;Participant;Patients;Physical environment;Physicians;Population;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;Poverty;Prevalence;Preventive measure;Principal Investigator;Program Development;programs;public trust;Publications;Race;racial minority;racial minority population;racial population;recruit;Reduce health disparities;Research;research and development;Research Personnel;Research Training;Risk;Role;Scholars Program;Scientist;seasonal influenza;Secure;Self Efficacy;senior faculty;skill acquisition;skills;social;social health determinants;social stigma;Structure;success;Syphilis;Teacher Professional Development;Testing;Training Programs;transmission process;trend;Tuberculosis;Underrepresented Populations;United States National Institutes of Health;Universities;visiting scholar;Woman;Writing

PROJECT_TITLE: UC San Diego RAPID Faculty Development Program in Infectious Diseases


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PI_NAMEs: BRUNO, TULLIA CARMELA (contact)

PROJECT_TERMS: Address;analytical tool;Archives;assay development;Biological;Biological Assay;Biometry;Budgets;Calibration;cancer cell;Cancer Center;Cancer Center Support Grant;Cell Separation;Cells;Cellular biology;Collaborations;Color;Complex;complex data;computerized tools;Continuing Education;Custom;Cytometry;Data;Data Analyses;Data Display;Data Set;Dedications;design;Detection;Disease;Education;Equipment;Event;experience;Experimental Designs;experimental study;Flow Cytometry;Fluorescence-Activated Cell Sorting;Fluorochrome;Funding;Genomics;Growth;Health Science Library;Heterogeneity;Hour;Immune;Immunity;Immunology;improved;Information Services;innovation;instrument;instrumentation;Investments;Journals;Knowledge;Laboratories;Lasers;Maintenance;Malignant Neoplasms;member;Methods;Mission;Modernization;Molecular Analysis;Molecular Biology;Monitor;Nature;NCI Center for Cancer Research;operation;Performance;Population;Publications;Qualifying;Reagent;recruit;Research;Research Personnel;Residual Neoplasm;Resource Sharing;Role;Services;Speed;Statistical Methods;System;Techniques;tool;Training;transcriptomics;tumor;Universities;user-friendly

PROJECT_TITLE: Cytometry Facility

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy

PI_NAMEs: HSU, YEN-MICHAEL S. (contact)

PROJECT_TERMS: American;anti-cancer research;Bioinformatics;Biological Assay;Biological Response Modifier Therapy;Biological Specimen Banks;Blood;Body Fluids;Budgets;Cancer Center;Cancer Center Support Grant;cancer diagnosis;cancer immunotherapy;Cancer Patient;cancer prevention;cancer therapy;cell preparation;Cell Therapy;Cells;Cellular Assay;cellular development;Certification;Characteristics;Clinic;Clinical;Clinical Laboratory Improvement Amendments;Clinical Protocols;Clinical Trials;college;Computers;Conduct Clinical Trials;Core Facility;Correlative Study;Development;digital;Enrollment;equipment acquisition;exosome;Foundations;Funding;Future;gene therapy;Goals;Good Manufacturing Process;Grant;Human Resources;Image Analysis;imaging facilities;imaging system;Immune;Immunologic Monitoring;Immunooncology;Immunotherapy;in vivo imaging;insight;Laboratories;Legal patent;liquid crystal polymer;Malignant Neoplasms;manufacture;member;Mission;Molecular Profiling;Monitor;nano-string;NCI Center for Cancer Research;novel;participant enrollment;Pathologist;Pathology;Patient Monitoring;Patient Participation;Phenotype;pre-clinical;preclinical development;preclinical study;Preparation;Procedures;Process;Production;programs;Protocols documentation;quality assurance;Research;Research Design;Research Personnel;Research Project Grants;response;Sampling;scale up;Services;single cell analysis;Societies;Specimen;System;Technology;Testing;Therapeutic;Therapeutic Clinical Trial;tissue preparation;tissue processing;Tissue Procurements;Tissue Stains;Training;transcriptome sequencing;Translational Research;Translations;treatment response;Tumor Tissue;tumor-immune system interactions;Viral

PROJECT_TITLE: Immunologic Monitoring and Cellular Products Laboratory


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Precision Medicine;Radiation Oncology

PI_NAMEs: COLEN, RIVKA R (contact)

PROJECT_TERMS: Address;Aftercare;Algorithms;Animal Cancer Model;Antigens;Antineoplastic Agents;Apoptosis;Back;Biological Markers;bioluminescence imaging;Budgets;cancer cell;Cancer Center;Cancer Center Support Grant;cancer imaging;Cancer Model;cancer research center director;cancer therapy;Cell Communication;Cell Physiology;Cells;Clinical;Clinical assessments;clinical imaging;Clinical Oncology;Clinical Research;Clinical Trials;co-clinical trial;Communication;Contrast Media;Detection;Development;Diagnosis;Disease;Drug Monitoring;early detection biomarkers;Early treatment;Evaluation;Event;FDA approved;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;Funding;Genomics;glucose metabolism;Goals;Head and Neck Squamous Cell Carcinoma;high dimensionality;Human;human model;Image;imaging biomarker;imaging facilities;Imaging Techniques;Imaging technology;Immune;Immune response;immune- related response criteria;Immunity;Immunotherapy;in vivo;in vivo imaging;in vivo imaging system;Journals;Magnetic Resonance Imaging;Malignant Neoplasms;Measurement;Measures;Medical Imaging;Melanoma;member;Methodology;Methods;Modality;molecular imaging;molecular marker;Monitor;multimodality;Names;Nature;Neoplasm Metastasis;non-invasive imaging;novel;novel therapeutics;Nuclear;Optics;Peer Review;PET/CT scan;Pharmacotherapy;Positron-Emission Tomography;pre-clinical;pre-clinical assessment;preclinical imaging;Production;Prognosis;programs;Proliferating;Protocols documentation;Publications;quantitative imaging;Radiogenomics;Radiology Specialty;radiomics;Radionuclide therapy;radiotracer;receptor;Receptor Cell;recruit;repository;Research Personnel;Resource Sharing;response;Rodent Model;Scanning;Services;Solid Neoplasm;Staging;targeted agent;Testing;theranostics;Tracer;Treatment Efficacy;treatment response;tumor;tumor diagnosis;tumor growth;Tumor Markers;tumor microenvironment;Tumor Volume;tumorigenesis;Validation;Visualization

PROJECT_TITLE: In Vivo Imaging Facility


NIH_SPENDING_CATS: Cancer;Networking and Information Technology R&D (NITRD)

PI_NAMEs: DHIR, RAJIV  (contact)

PROJECT_TERMS: Algorithmic Analysis;American;Antibodies;Apoptosis;automated image analysis;biobank;Bioinformatics;Biological;Biological Specimen Banks;Bromodeoxyuridine;Budgets;Cancer Center;Cancer Center Support Grant;Cell Proliferation;Certification;Clinical;Clinical Data;Clinical Laboratory Information Systems;Clinical Research;Collection;college;Community Hospitals;Computerized Medical Record;cost;Cytoplasm;Data;data centers;data management;Databases;design;Development;Diagnostic;Equipment;Ethics;Evaluation;experience;Frozen Sections;Funding;Glass;Goals;Head and neck structure;Health Sciences;Histology;Hospitals;Hour;Human;Image;Image Analysis;Image Enhancement;imaging facilities;Immunohistochemistry;Immunologic Monitoring;Individual;Information Retrieval;innovation;Institution;Institutional Review Boards;interest;Investigation;Laboratories;liquid crystal polymer;Lung;Malignant neoplasm of ovary;Malignant Neoplasms;manufacture;Medical;Melanoma;member;Modeling;Monitor;morphometry;novel;Nuclear;Paraffin Tissue;Pathologist;Pathology;Patients;Pattern;Pediatric Hospitals;Play;pre-clinical research;Presbyterian Church;Price;Process;programs;Proteomics;Protocols documentation;quantitative imaging;Registries;Research;research facility;Research Personnel;research study;Resource Sharing;Resources;Retrieval;Role;sample collection;Sampling;Science;service utilization;Services;Site;Skin Cancer;Slide;Specimen;Stains;Supervision;System;Systems Analysis;TdT-Mediated dUTP Nick End Labeling Assay;Techniques;Text;The Cancer Genome Atlas;Tissue Banks;Tissue Microarray;Tissue Preservation;Tissue Sample;Tissues;Translational Research;Triage;Trichrome stain method;tumor;Universities;whole slide imaging;Woman;Work

PROJECT_TITLE: Tissue and Research Pathology Services


ADMINISTERING_IC: OD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: SAN MARCOS

ORG_NAME: TEXAS STATE UNIVERSITY

ORG_STATE: TX

PHR: Narrative Disease driver genes have been identified in the past few decades, advancing both mechanistic understanding of disease and therapeutic development. However, the genetic background impacts considerably on the phenotype of a specific disease. These effects are due to genetic background and/or environmental influence on the disease driver, complicating diagnosis and proper treatment selection. Therefore, it is of utmost importance and relevance to investigate genetic background effects on disease development and progression. We now understand that genetic background effects are due to epistatic interactions that modulate disease driver function. However, common animal models are not suitable for studying this question because laboratory strains of these animals are mostly inbred and selected for laboratory use. Because they are closely related and at best represent different populations of just one species, they do not constitute high enough genetic diversity to allow identification of modulating epistasis. To circumvent this hurdle, we propose to implement various Xiphophorus fish species. These species present high inter-species phenotypical and genetic variation and harbor natural alleles that are disease associated. They offer the possibility of producing artificial inter-species hybrids, providing the unique possibility to investigate epistasis underlying diseases including cancer, metabolic disorders and aberrant disease related molecular traits. This suitability makes Xiphophorus the experimental model organism of choice to fill a knowledge gap in disease model research and to develop innovative research strategies. Xiphophorus is a genus of live-bearing freshwater fish that includes 26 species. The Xiphophorus Genetic Stock Center is a national resource center that hosts 61 pedigree lines that belong to 24 species. The goal of the XGSC is to maintain the unique features and preserve the strength of this model to be used in biomedical research.

PI_NAMEs: GABOR, CAITLIN ;LU, YUAN  (contact);SCHARTL, MANFRED

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: Access to Information;Affect;Alleles;Animal Housing;Animal Husbandry;Animal Model;animal resource;Animals;Area;Automobile Driving;Backcrossings;Behavior;bioinformatics tool;Biological;Biological Models;Biology;Biomedical Research;Cancer Etiology;candidate identification;cell type;Cells;Chromosomes;Chronobiology;Communities;Complex;Consult;Control Locus;Country;Data;Development;Diagnosis;Discipline;Disease;disease diagnosis;disease model;disease phenotype;Disease Progression;Distant;Embryology;Endocrinology;Ensure;Epigenetic Process;Etiology;Exhibits;Experimental Models;Fishes;Fresh Water;functional genomics;Future;Gene Expression;gene interaction;Genes;Genetic;Genetic Drift;Genetic Epistasis;genetic pedigree;genetic resource;genetic variant;Genetic Variation;Genome;genome resource;genomic locus;Genomics;Genotype;Goals;Health;Histocompatibility;Human;human disease;human model;Hybrids;Immunology;Improve Access;improved;Inbreeding;innovation;Institution;International;Knowledge;Laboratories;Lead;Malignant Neoplasms;medical specialties;Metabolic Diseases;Mission;model development;model organism;Modeling;Molecular;molecular phenotype;novel;novel therapeutic intervention;nutrition;Obesity;obesity development;operation;Optics;Organ;Orthologous Gene;Outcome;Parasitology;personalized medicine;Phenotype;Physiology;Play;Population;Positioning Attribute;preservation;Procedures;Production;Publications;Publishing;Quantitative Trait Loci;Regulation;Research;Research Personnel;Research Training;Resources;Role;Selection for Treatments;Services;Signal Transduction;student training;Study models;System;Texas;therapeutic development;Tissues;Toxicology;Training;trait;transcriptomics;translational model;Translational Research;tumor progression;tumorigenesis;United States National Institutes of Health;Universities;Variant;Xiphophorus

PROJECT_TITLE: Advancement of the Xiphophorus Model for Studying Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-F(55)R]


NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Climate-Related Exposures and Conditions;Genetics;Human Genome;Neuroblastoma;Neurosciences;Orphan Drug;Prevention;Rare Diseases;Social Determinants of Health

PI_NAMEs: OPRESKO, PATRICIA L (contact)

PROJECT_TERMS: adaptive immunity;Aging;Air Pollution;Area;ataxia telangiectasia mutated protein;base;Basic Science;Biological;biological adaptation to stress;Biological Assay;Biological Markers;Biology;Biotin;cancer cell;Cancer Center;Cancer Center Support Grant;cancer diagnosis;cancer type;carcinogenesis;Catchment Area;Cell Aging;Cell Death;Cells;Chemicals;Chromosome abnormality;Cisplatin;clinical application;Clinical Research;Collaborations;Collection;Communication;daughter cell;Deamination;Dedications;Depurination;Development;diagnostic strategy;DNA Adducts;DNA Damage;DNA lesion;DNA Repair;DNA Repair Enzymes;DNA Repair Gene;DNA Repair Pathway;DNA replication fork;DNA-Directed DNA Polymerase;Doctor of Philosophy;drug discovery;Education;Environmental Health;Environmental Risk Factor;Epigenetic Process;Faculty;Functional disorder;fundamental research;Funding;Genes;Genetic Materials;Genome;genome integrity;Genome Stability;Genomic Instability;Genomics;Genotoxic Stress;genotoxicity;Goals;Growth;Human body;human DNA;Immune response;Immunologic Factors;Inflammatory;inhibitor;innovation;insight;inter-institutional;interest;International;Ionizing radiation;kinase inhibitor;Laboratories;Link;Malignant Neoplasms;member;Mentors;Mitochondria;mitochondrial dysfunction;Molecular;molecular oncology;Mothers;mouse model;multidisciplinary;Mus;Mutation;Natural Immunity;neoplastic cell;Neuroblastoma;next generation;novel;novel therapeutics;Occupational Health;Oncogene Activation;Oral;Outcome;oxidation;oxidative damage;oxidative DNA damage;Oxidative Stress;Pathway interactions;Peer Review;Pharmacology;Phase;preclinical study;Prevention;Prevention strategy;Process;professor;programs;Proteins;Publications;Publishing;Radiation induced damage;radiation mitigation;Radon;Reactive Oxygen Species;real-time images;recruit;repaired;Research;research faculty;Research Personnel;Research Support;response;Risk Factors;Role;Schools;Scientist;Seminal;Series;single molecule;small molecule;Source;stem;Structure;Sunlight;synergism;telomere;Telomere Maintenance;Telomere Pathway;Therapeutic;three dimensional cell culture;tool;Translating;Translations;treatment strategy;tumor;Tumor Suppressor Genes;Universities;Validation;Work;Xenograft procedure

PROJECT_TITLE: Genome Stability Program


NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Prevention;Rare Diseases

PI_NAMEs: GUO, HAITAO  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;AIDS related cancer;anti-cancer;anti-cancer research;anti-hepatitis C;Anti-viral Agents;antiretroviral therapy;Area;Biological Models;Burkitt Lymphoma;Cancer Center;Cancer Center Support Grant;cancer prevention;Caring;Catchment Area;Chronic;Collaborations;cost;Doctor of Philosophy;Environment;Epidemiology;Funding;General Population;Generations;Goals;Hepatitis B Virus;Hepatitis C virus;HIV;Hodgkin Disease;Human;Human Herpesvirus 4;Human Herpesvirus 8;Human Papillomavirus;Human T-lymphotropic virus 1;Immunization Programs;Incidence;inter-institutional;International;Intervention;Kaposi Sarcoma;Knowledge;Leadership;Malignant Neoplasms;malignant stomach neoplasm;Medical;meetings;member;Mentors;Merkel Cells;Mission;Morbidity - disease rate;mortality;Nasopharynx Carcinoma;new therapeutic target;Non-Hodgkin's Lymphoma;novel marker;Pathway interactions;Patient Care;Patients;Peer Review;Pharmaceutical Preparations;Pilot Projects;Polyomavirus;Population;prevent;Prevention;Primary carcinoma of the liver cells;Productivity;programs;Publications;Publishing;Recruitment Activity;Research;Research Personnel;Research Project Grants;Research Support;Resources;Schools;Scientist;success;symposium;targeted treatment;Therapeutic;Universities;vaccine access;Vaccines;Viral;Viral Cancer;virology;Virus;Virus Diseases;virus related cancer

PROJECT_TITLE: Cancer Virology Program


ADMINISTERING_IC: GM

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases;Networking and Information Technology R&D (NITRD)

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative We now generate so much genetic data that we no longer have the capacity to analyze it all. This has limited our ability to make new scientific discoveries and combat the ongoing pandemic. This research will develop efficient new methods for analyzing large numbers of genomes, so that we can learn about evolution and natural selection in unprecedented detail.

PI_NAMEs: TERHORST, JONATHAN G (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: 2019-nCoV;Address;Area;biobank;combat;Computer software;Computing Methodologies;Coronavirus;Data;Data Set;design;Epidemiologic Methods;Evolution;fitness;Genetic;genetic epidemiology;Genetic Recombination;Genome;Genomics;improved;innovation;Learning;Methods;Modeling;Modernization;Natural Selections;next generation;next generation sequencing;non-genetic;novel;open source;pandemic disease;pathogen genome;Pathway Analysis;Persons;Phylogenetic Analysis;Play;Public Health;repository;Reproduction;Research;Research Personnel;Role;Sampling;SARS-CoV-2 genome;Shapes;Source;Statistical Methods;System;Techniques;Technology;Time;tool;Trees;Variant;Work

PROJECT_TITLE: Large-scale phylodynamics under non-neutral and non-treelike models of evolution

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


NIH_SPENDING_CATS: Cancer;Data Science;Prevention

PI_NAMEs: BUCKANOVICH, RONALD J (contact)

PROJECT_TERMS: Acceleration;Area;Award;Biology;Cancer Biology;Cancer Center;Cancer Center Support Grant;cancer initiation;Catchment Area;Cellular biology;Chemicals;Clinic;Clinical Investigator;Clinical Research;Collaborations;Data Science;Development;Diagnosis;Diagnostic;disease model;Doctor of Philosophy;Drug resistance;Equipment;Event;Faculty;Financial Support;Fostering;Funding;Goals;Hematology;Hormones;improved;in silico;In Vitro;in vivo;Incidence;inter-institutional;Internal Medicine;International;Joints;Malignant - descriptor;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;meetings;member;Mentors;Mission;Modeling;Molecular;mortality;Neoplasm Metastasis;next generation;novel;Oncology;Peer Review;Pharmacology;Pilot Projects;Prevention;Preventive;professor;programs;Publications;Publishing;recruit;Research;Research Activity;Research Personnel;Resource Sharing;response;Schools;scientific organization;Seminal;Series;Signal Transduction;Strategic vision;symposium;Talents;Therapeutic;Translational Research;treatment strategy;tumor initiation;tumor progression;Universities;Work

PROJECT_TITLE: Cancer Biology Program


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Breast Cancer;Cancer;Colorectal Cancer;Digestive Diseases;Lung;Lung Cancer;Prevention;Rare Diseases;Women's Health Research

PI_NAMEs: HERMAN, JAMES G. (contact)

PROJECT_TERMS: Activities of Daily Living;anti-cancer;anti-cancer research;Award;Behavioral;biobank;Biological;biomarker validation;Body Weight decreased;Breast;Breast Cancer Early Detection;cancer biomarkers;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer diagnosis;cancer epidemiology;Cancer Etiology;cancer genomics;cancer initiation;Cancer Patient;cancer prevention;Cancer Prevention Intervention;Cancer Survivorship;cancer type;Cancer Vaccines;Catchment Area;Cessation of life;Clinical;Clinical Data;Clinical Research;Clinical Trials;cohort;Collaborations;Colorectal Cancer;detection method;Development;dietary;Doctor of Philosophy;Early Diagnosis;education research;efficacy evaluation;Environmental Exposure;Epidemiologic Methods;Etiology;experience;Funding;Future;gene environment interaction;Genetic;Goals;Grant;Head and neck structure;Imaging Techniques;Imaging technology;Immune response;improved;Incidence;innovation;inter-institutional;International;Large Intestine Carcinoma;Leadership;Lung;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Melanoma;member;metabolomics;Methodology;microbiome;Mission;Modernization;mortality;Mucin 1 protein;Natural Compound;Nature;NCI-Designated Cancer Center;next generation;novel;novel marker;novel strategies;Outcome;Ovarian;Pancreatic carcinoma;Paper;Peripheral;Population;population based;Population Research;Population Sciences;pre-clinical;prevention effectiveness;Prevention program;Prevention Research;Prevention strategy;Primary Cancer Prevention;Primary carcinoma of the liver cells;programs;Publications;Publishing;Quality of life;radiological imaging;randomized, clinical trials;Research;Research Activity;Research Design;Research Personnel;Research Project Grants;Resources;response biomarker;Risk;Risk Factors;Sampling;Schools;Science;Scientific Advances and Accomplishments;Scientist;screening;Screening for cancer;smoking cessation;Source;Strategic Planning;Sulforaphane;Symptoms;synergism;Technology;Training and Education;Translating;Translational Research;ultrasound;Universities;Vaccines;Validation;Weight maintenance regimen;Woman;working group

PROJECT_TITLE: Cancer Epidemiology and Prevention Program


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Obesity;Prevention;Rehabilitation;Tobacco;Tobacco Smoke and Health

PI_NAMEs: BOVBJERG, DANA H. (contact)

PROJECT_TERMS: Activities of Daily Living;Address;Adherence;Adolescent;Age;Behavior;Behavioral;Behavioral Mechanisms;Behavioral Sciences;biobehavior;Biological;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Control Research;cancer prevention;cancer risk;Cancer Survivor;Cancer Survivorship;cancer therapy;Caregivers;Catchment Area;Clinic;Clinical Research;Clinical Trials;Collaborations;common symptom;Development;Diet;Disease;Doctor of Philosophy;Etiology;experience;Funding;Goals;Grant;High Prevalence;improved;improved outcome;innovation;inter-institutional;Intervention;Intervention Trial;Investments;Leadership;Length;Link;Maintenance;Malignant Neoplasms;member;Obesity;Oncology;Pathway interactions;Patients;Peer Review;Pennsylvania;personalized management;Persons;Phase;Physical activity;Population;pre-clinical research;prevent;Productivity;programs;psychosocial;Publications;Publishing;Quality of life;Randomized;randomized, clinical trials;reduce symptoms;reduce tobacco use;Research;Research Activity;Research Personnel;research study;Research Support;Risk;Risk Behaviors;Risk Reduction;Schools;sedentary lifestyle;socioeconomic disadvantage;Strategic Planning;Survivors;survivorship;symptom management;Symptoms;Testing;Tobacco use;Tobacco Use Cessation;Translational Research;treatment adherence;Treatment-Related Cancer;tumor;Underserved Population;United States;Universities;Vulnerable Populations;Work

PROJECT_TITLE: Biobehavioral Cancer Control Program


PI_NAMEs: DELGOFFE, GREG M. (contact)

PROJECT_TERMS: Acceleration;Address;Automobile Driving;bench to bedside;Biotechnology;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer immunotherapy;Cancer Patient;cancer prevention;cancer therapy;Cancer Therapy Evaluation Program;Cancer Vaccines;Catchment Area;chemotherapy;Clinic;Clinical;Clinical Investigator;clinical practice;clinical translation;Clinical Trials;Collaborations;Colon Carcinoma;Combination immunotherapy;design;Development;Disease;Doctor of Philosophy;Ensure;Epigenetic Process;fighting;Funding;Genetic Transcription;Geography;Goals;Grant;Head and Neck Cancer;Human;Immune;immune checkpoint;Immune system;Immunologist;Immunooncology;Immunophenotyping;Immunoprevention;immunoregulation;Immunotherapeutic agent;Immunotherapy;immunotherapy clinical trials;immunotherapy trials;improved;industry partner;innovation;inter-institutional;Intervention;Laboratory Finding;Laboratory Research;Leadership;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Melanoma;member;Mission;Molecular;new therapeutic target;next generation;novel;novel marker;Obesity;Operative Surgical Procedures;Outcome;Pathologist;Patients;Peer Review;Pre-Clinical Model;precision medicine;predictive marker;prevent;Prevention;programs;prophylactic;Publications;Publishing;Radiation;Recording of previous events;recruit;Research;Research Personnel;Research Support;response biomarker;Sampling;Schools;Science;Sun Exposure;targeted biomarker;targeted treatment;Testing;Therapeutic;therapy resistant;Tobacco use;Training and Education;Translating;Translational Research;translational scientist;Translations;tumor;Tumor Escape;Tumor Immunity;tumor immunology;tumor microenvironment;tumor-immune system interactions;Universities;Validation;Work

PROJECT_TITLE: Cancer Immunology and Immunotherapy Program


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: BRUFSKY, ADAM M (contact)

PROJECT_TERMS: anti-cancer research;Antineoplastic Agents;Bioinformatics;Biological Assay;Cancer Center;Cancer Center Support Grant;cancer pharmacology;cancer therapy;Clinical;Clinical Data;clinical development;Clinical Investigator;Clinical Protocols;Clinical Trials;Collaborations;Complement;Credentialing;data management;design;Development;Developmental Therapeutics Program;Direct Costs;Doctor of Philosophy;drug development;drug discovery;Funding;Goals;Human;improved;Industry;innovation;inter-institutional;Interdisciplinary Study;interest;Investigation;Laboratories;Leadership;Malignant Neoplasms;member;Mission;National Cancer Institute;NCI Center for Cancer Research;novel;novel anticancer drug;novel therapeutics;Peer Review;Phase;pre-clinical;preclinical development;programs;Publications;Publishing;recruit;Regimen;Research;Research Personnel;Research Support;Resistance;Resource Sharing;Schools;Science;Scientist;Therapeutic;Translating;Translational Research;translational scientist;Translations;Treatment Protocols;Universities

PROJECT_TITLE: Cancer Therapeutics Program


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Urologic Diseases;Women's Health Research

PI_NAMEs: BASKIN, MONICA L. (contact)

PROJECT_TERMS: access disparities;Address;advocacy organizations;Age;Appalachian Region;Behavior;Behavioral Risk Factor Surveillance System;Belief;Biological Markers;Breast;Breast Cancer Detection;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer health disparity;cancer risk;cancer therapy;Caring;Catchment Area;Centers for Disease Control and Prevention (U.S.);Cervical Cancer Screening;Clinical Cancer Center;Clinical Trials;Collaborations;Collection;Colon Carcinoma;Colorectal;Colorectal Cancer;colorectal cancer screening;Communities;community advisory board;community engagement;Community Health;Community Outreach;community partners;community partnership;Community Surveys;Comprehensive Cancer Center;Continuity of Patient Care;County;Data;data dissemination;Data Sources;Databases;Development;disparity reduction;Education;Effectiveness;Ensure;Environment;Equity;Evaluation;evidence base;Evidence based intervention;Feedback;Future;Geography;Government;Health;health equity;Health Service Area;health service use;Health Services Accessibility;HPV vaccine acceptance;Improve Access;improved;Incidence;Informatics;infrastructure development;Lead;Leadership;Low income;Lung;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant neoplasm of thyroid;Malignant Neoplasms;meetings;Melanoma;member;Minority;Minority Groups;minority patient;Minority Recruitment;Monitor;mortality;multiple data sources;NCI Center for Cancer Research;neoplasm registry;New Agents;novel;Obesity;outreach;Pancreas;patient navigation;Patients;Pennsylvania;Policies;Population;Population Heterogeneity;Prevention;Process;programs;Prostate;Race;racial disparity;recruit;Research;Research Priority;resilience;Resources;response;Risk;Risk Behaviors;Rural;rural area;Rural Population;scaffold;Science;screening;Screening for cancer;statistics;Strategic Planning;Surveys;survivorship;symposium;synergism;System;Thyroid Gland;Time trend;Tobacco use;Tobacco Use Cessation;underserved area;Urban Population;Voice;Work

PROJECT_TITLE: Community Outreach and Engagement


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: BURLINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: Mammarenaviruses often cause severe diseases in humans but establish asymptomatic, lifelong infections in rodent reservoirs. We aim to identify the cellular processes that differentially regulate infectious versus defective particle production and the ecological impact of these defective viral particles on rodent reservoir fitness. This work has the potential to answer long-standing questions regarding for how zoonotic viruses, including those in the Bunyavirales order, are maintained in reservoir species in nature.

PI_NAMEs: BOTTEN, JASON W. (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: acute infection;Address;Animals;Arenavirus;Binding;Bunyavirales;Cell Physiology;Cells;chronic infection;Defective Viruses;Disease;Ecology;Engineering;Ensure;Environmental Impact;Family;fitness;Goals;Human;human pathogen;Immune response;Immunity;in vivo;Infection;innovation;Integration Host Factors;Investigation;Knowledge;Ligase;Link;Lymphocytic choriomeningitis virus;Maintenance;Maps;Modification;Molecular;Mus;Nature;novel;particle;pathogen;Pathogenesis;pathogenic virus;Pathway interactions;Phosphorylation;Phosphotransferases;plasma protein Z;Polymerase;Post-Translational Protein Processing;Production;Property;Protein Tyrosine Kinase;Proteins;Proteome;Reagent;Recombinants;recruit;Regulation;Resolution;reverse genetics;RNA Viruses;Rodent;Role;Site;Study models;System;Testing;Time;tool;trafficking;transmission process;ubiquitin-protein ligase;Ubiquitination;vector;Viral;Viral Matrix Proteins;Viral Pathogenesis;Viral Proteins;Virion;virology;Virus;Virus Diseases;virus host interaction;Work;Zoonoses

PROJECT_TITLE: The role of mammarenavirus defective interfering particles in protecting host fitness and the host-driven post-translational modifications that regulate their formation and function


NIH_SPENDING_CATS: Cancer;Clinical Research

PI_NAMEs: FERRIS, ROBERT L. (contact)

PROJECT_TERMS: Address;Adopted;Advisory Committees;Aging;anti-cancer research;Appointment;Area;Attention;Award;Basic Science;Behavior;Bioinformatics;Cancer Center;Cancer Center Support Grant;cancer genomics;cancer research center director;care delivery;Catchment Area;Categories;Clinical;clinical care;Clinical Investigator;Clinical Sciences;Clinical Trials;Collaborations;Communities;Core Facility;Development;Education;Ensure;equipment acquisition;Evaluation;Extramural Activities;Faculty;Faculty Recruitment;fundamental research;Funding;Goals;Grant;Guidelines;high risk;improved;Incubated;innovation;Institution;Investments;Leadership;Malignant Neoplasms;member;metabolomics;microbiome;microbiome research;NCI Center for Cancer Research;new technology;novel strategies;Obesity;Pilot Projects;Population;Population Sciences;population survey;Preparation;Process;programs;recruit;Research;Research Personnel;Research Priority;Research Project Grants;Resource Sharing;Science;Scientist;Secure;Strategic Planning;Strategic vision;success;Translating;translational immunology;Translational Research;translational scientist;Translations;virology;Vision;Work

PROJECT_TITLE: Developmental Funds


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because asthma is the most common chronic respiratory illness and the most common chronic childhood illness. Genetics contribute to asthma risk, although the how they affect specific cell types in asthma is not well understood, and this project will delineate genetic contributions to important subsets of asthma and determine their effects in cell types pertinent to asthma. This project is relevant to the NIH mission because it seeks knowledge about asthma with a goal of enhancing health, lengthening life and reducing illness and disability.

PI_NAMEs: SCHOETTLER, NATHAN R (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: Academic advising;Acceleration;Address;Adult;Affect;Age of Onset;age stratification;Alleles;analytical method;Area;Asthma;Asthma COPD Overlap Syndrome;asthmatic patient;Award;biobank;Blood;bronchial epithelium;career;career development;causal variant;cell type;Cells;Cellular biology;Cellular Immunology;Chicago;Childhood;Chronic;Clinical;clinical care;clinical heterogeneity;Complement;Complex;Coupling;cytokine;Data;design;Development Plans;disability;Disease;disorder risk;Doctor of Philosophy;draining lymph node;Epithelial Cells;Evaluation;Fellowship;Foundations;Funding;Future;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic association;Genetic Diseases;Genetic Risk;genetic risk factor;genetic variant;Genetic Variation;genome wide association study;Genotype;Goals;Health;Heritability;Human;Human Resources;Immunology;improved outcome;insight;Knowledge;Laboratories;Learning;Life;Linear Models;Link;Lung;Maps;Mediating;Memory;Mentors;Mission;Modeling;Molecular Biology;mouse model;novel;Pathogenesis;Pathway interactions;Pattern;personalized medicine;Phase;Phenotype;Physicians;Play;Positioning Attribute;Postdoctoral Fellow;progenitor;programs;Public Health;Quantitative Trait Loci;Research;research and development;Research Personnel;Research Proposals;Resources;respiratory;respiratory smooth muscle;response;Risk;risk sharing;risk variant;RNA Splicing;Role;Scientist;single-cell RNA sequencing;skills;Smooth Muscle Myocytes;Structure of parenchyma of lung;T memory cell;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Techniques;Testing;therapeutic target;Time;tissue resident memory T cell;Tissues;Training;trait;transcriptome sequencing;Translating;translational study;United States National Institutes of Health;Universities;Variant

PROJECT_TITLE: Genetics of Asthma Sub-Phenotypes Impact Gene Regulation in Cell-Specific Patterns

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


NIH_SPENDING_CATS: Cancer

PROJECT_TERMS: Achievement;Advisory Committees;anti-cancer research;Appointment;Area;Award;Basic Science;Cancer Center;Cancer Center Support Grant;cancer education;cancer research center director;Catchment Area;Chad;Clinical Cancer Center;Clinical Research;Clinical Sciences;community advisory board;community engagement;Community Healthcare;Community Outreach;Decision Making;Doctor of Philosophy;Effectiveness;Ensure;Equipment;Evaluation;Evaluation Research;Event;Extramural Activities;Feedback;Funding;Future;Goals;Growth and Development function;health equity;Health Professional;improved;Individual;Institution;Leadership;meetings;member;Mission;Monitor;operation;Operations Research;organizational structure;outreach;Policies;Population;Population Sciences;Process;programs;recruit;Research;Research Activity;Research Personnel;Research Priority;Research Support;Resource Sharing;Resources;Science;Site Visit;Strategic Planning;Strategic vision;Structure;Surveys;symposium;System;Training and Education;training opportunity;Translational Research;Vision;Work

PROJECT_TITLE: Leadership, Planning and Evaluation


NIH_SPENDING_CATS: Cancer;Orphan Drug;Palliative Care;Patient Safety;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

PI_NAMEs: LUKE, JASON JOHN (contact)

PROJECT_TERMS: Adult;advocacy organizations;Age;Appointment;Area;Basic Science;biobank;biobehavior;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Catchment Area;Child;Childhood;Clinical;Clinical Cancer Center;Clinical Data;Clinical Investigator;Clinical Management;Clinical Protocols;Clinical Research;clinical trial enrollment;Clinical Trials;Collaborations;Communities;Community Clinical Oncology Program;community collaboration;Community Health Education;Community Outreach;Conduct Clinical Trials;County;Data;data management;data quality;Development;Disease;Doctor of Philosophy;Early Diagnosis;Education;Eligibility Determination;Enrollment;Ensure;Ethnic Origin;experience;Goals;Guidelines;health equity;Human Subject Research;improved;Industry;Infrastructure;innovation;Institution;Intervention;Intervention Trial;investigator-initiated trial;Investments;Leadership;male;Malignant Neoplasms;Minority;Minority Enrollment;Minority Participation;minority patient;Mission;Modality;Monitor;Monitoring Clinical Trials;National Clinical Trials Network;Natural Language Processing;novel;Oncology;oncology program;operation;Operations Research;Palliative Care;participant enrollment;Patient advocacy;Patient Care;patient safety;Patients;Pediatric Hospitals;Pediatric Oncology;Peer Review;Pennsylvania;Phase;Play;Procedures;Process;programs;Quality Control;Race;recruit;Regimen;Reporting;Research;Research Personnel;Research Training;Safety;screening;Services;smartphone application;Strategic Planning;Supportive care;Therapeutic;Therapeutic Clinical Trial;Therapeutic Trials;translational oncology;translational research program;trend;Universities;Vendor;Woman;women patients

PROJECT_TITLE: Clinical Protocol and Data Management


NIH_SPENDING_CATS: Cancer;Patient Safety

PI_NAMEs: APPLEMAN, LEONARD J. (contact)

PROJECT_TERMS: Accreditation;authority;Benchmarking;biobehavior;Biometry;Caliber;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Cancer Control;cancer epidemiology;cancer prevention;cancer research center director;Clinical;Clinical Data;Clinical Protocols;Clinical Research;Clinical Trials;Complementary Medicine;Conduct Clinical Trials;Conflict of Interest;Consultations;Data;data management;data quality;Disease;Doctor of Philosophy;Early Therapeutic-Clinical Trials Network;Ensure;Goals;Industry;Institution;Institutional Review Boards;investigator-initiated trial;Malignant Neoplasms;Medical Oncology;member;Modality;Monitor;Names;Nursing Faculty;oncology trial;Pathologist;Patients;Pediatric Oncology;Peer Review;Pharmacists;Protocols documentation;Radiation Oncology;Recommendation;Research Design;Research Personnel;Resources;Review Committee;Role;Safety;Surgical Oncology;System;tumor progression;Work

PROJECT_TITLE: Protocol Review and Monitoring System


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Genetic factors play a major role in the etiology of breast cancer. However, little is known about the target genes for breast cancer genetic risk regions identified in recent years, and further a large fraction of heritability for this common malignancy remains unexplained. In this application, we propose a novel study to systematically search for genes associated with breast cancer risk and further evaluate whether these genes may influence racial differences in the risk of this cancer.

PI_NAMEs: LONG, JIRONG ;ZHENG, WEI  (contact)

PROGRAM_OFFICER_NAME: MECHANIC, LEAH E

PROJECT_TERMS: ABCC1 gene;Acceleration;African;African ancestry;African Women;Asia;Asian;Asian ancestry;Asian population;Asian Women;Bioinformatics;Biological;Biological Assay;Biological Process;Breast Cancer gene;Breast Cancer Genetics;Breast Cancer Patient;Breast Cancer Risk Factor;Cancer Biology;Cancer Control;cancer genetics;cancer risk;Cancer-Predisposing Gene;Candidate Disease Gene;causal variant;Cell Physiology;Complex;cost;cost efficient;Data;density;Disease;Disease susceptibility;disorder prevention;disorder risk;ERBB2 gene;Estrogen Receptors;Etiology;European;European ancestry;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Models;genetic predictors;Genetic Risk;Genetic study;genetic variant;Genome;genome sequencing;genome wide association study;genomic data;Genomics;Genotype;Genotype-Tissue Expression Project;Hereditary Breast Carcinoma;Heritability;improved;In Vitro;in vitro Assay;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammary Neoplasms;Maps;Methodology;Modeling;molecular subtypes;novel;novel strategies;Patient Care;Phenotype;Pilot Projects;Play;predictive modeling;Race;racial difference;racial population;Risk;risk variant;Role;Sample Size;Sampling;Testing;The Cancer Genome Atlas;Tissue Sample;Tissues;trait;transcriptome;transcriptome sequencing;transcriptomics;Translating;translational genetics;Tumor Tissue;whole genome

PROJECT_TITLE: Integrating genomic and transcriptomic data to identify breast cancer susceptibility genes

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Neurosciences;Substance Misuse

ORG_CITY: WORCESTER

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PUBLIC HEALTH RELEVANCE: Alcoholism poses an enormous health and financial burden on our society. Currently, our understanding of the brain circuitries involved in alcoholism is far from complete. The successful completion of these proposed studies would result in important new information about neurons that may be involved in alcoholism, potentially creating new targets for therapeutics development.

PI_NAMEs: WINDER, DANNY G. (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Ablation;Abstinence;Acute;Adrenergic Receptor;Affective;affective disturbance;alcohol abstinence;Alcohol consumption;Alcohol dehydrogenase;Alcohol dependence;alcohol exposure;alcohol sensitivity;alcohol use disorder;Alcohol withdrawal syndrome;Alcoholism;Alcohols;Amygdaloid structure;anti-depressive agents;Anxiety;Behavior;Behavioral;behavioral outcome;behavioral response;brain circuitry;Cell Nucleus;Chronic;Corticotropin-Releasing Hormone Receptors;Data;depressive behavior;Development;diphtheria toxin receptor;Down-Regulation;drinking;drinking behavior;drug action;Ethanol;Ethanol dependence;experimental study;Family history of;Financial Hardship;Funding;glutamatergic signaling;Glutamates;Health;Human;inhibitor;Ketamine;Knockout Mice;Literature;Long-Term Depression;Long-Term Potentiation;Maps;Masks;Mediating;Mental Depression;Messenger RNA;Modeling;Mus;N-Methyl-D-Aspartate Receptors;Negative Reinforcements;Neurons;Neuropeptides;new therapeutic target;NMDA receptor antagonist;Play;postsynaptic;presynaptic;Procedures;Process;public health relevance;Pyrazoles;receptor;receptor function;Receptor Signaling;receptor-mediated signaling;Regulation;Reporter;Rewards;Role;Series;Signal Transduction;Societies;Stress;Structure of terminal stria nuclei of preoptic region;success;Synapses;Synaptic plasticity;System;Testing;therapeutic development;transmission process;Up-Regulation

PROJECT_TITLE: Alcohol action on extended amygdala glutamate synapses

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Project Narrative The relevance of the New Mexico Minority-Underserved NCORP (MU-NCORP) lies in the deep rooted mission of our longstanding partnership of academic and community cancer providers and other community stakeholders managed through a unique statewide consortium infrastructure (UNM Comprehensive Cancer Center and the New Mexico Cancer Care Alliance) to deliver the highest quality in all aspects of cancer care (cancer screening, prevention control and cancer care delivery) to all New Mexicans with a strong focus on eradicating disparities in access, care delivery and outcomes. Our growth as an NCI Comprehensive Cancer Center with scientific programmatic focus on innovative approaches to cancer delivery and disparities research in our unique New Mexican populations in conjunction with our longstanding community partnerships through nearly 20 years of work as an MB-CCOP and now MU-NCOORP continues to support our progress in meaningful reduction in cancer burden and better understanding of barriers to care for our population. Continued team work with all academic, community oncology and tribal and other community stakeholders while serving as leaders within the NCI NCORP, CTEP and DCP with bidirectional research engagement will continue to strengthen our program and effectiveness in improving quality and length of life for New Mexicans and other minority populations.

PI_NAMEs: MULLER, CAROLYN Y (contact)

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: Academic Medical Centers;access disparities;Address;Adolescent;Advisory Committees;Aftercare;American Indians;Asian;Award;Awareness;barrier to care;base;Black race;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Cancer Control;cancer health disparity;Cancer Patient;cancer prevention;Cancer Therapy Evaluation Program;care delivery;care outcomes;care providers;Catchment Area;Childhood;Clinical;Clinical Trials;Clinical Trials Cooperative Group;Clinical Trials Network;Collaborations;Communities;community based participatory research;Community Clinical Oncology Program;Community Health;Community Health Systems;community partners;community partnership;community setting;Comprehensive Cancer Center;County;data resource;Disparate;Disparity;Effectiveness;Enrollment;ethnic minority;Ethnic Population;Foundations;gender minority;Genomics;Geography;Goals;Grant;Growth;Health;health disparity;Health Insurance;Health Personnel;Health system;Hispanic;Hispanic Populations;Hospitals;Image;improved;Income;Infrastructure;innovation;interest;Intervention;Joints;Knowledge;Leadership;Longevity;Malignant Neoplasms;member;Mexican;Minority;Minority Groups;Mission;Modeling;Molecular;multi-ethnic;National Clinical Trials Network;New Mexico;next generation;Not Hispanic or Latino;outcome disparities;outreach program;participant enrollment;patient oriented;Patient-Focused Outcomes;Patients;Pattern;Physicians;Population;Population Heterogeneity;Population Sciences;Poverty;Prevention;prevention clinical trial;preventive intervention;programs;Provider;Research;Research Methodology;Rural;Rural Community;Rural Population;Scientist;screening;Screening for cancer;Site;Strategic Planning;success;System;Therapeutic;Therapeutic Clinical Trial;Therapeutic Intervention;Therapeutic Trials;tissue resource;tribal Nation;Tribes;underserved community;underserved minority;Underserved Population;Universities;virtual;Work;working group;young adult

PROJECT_TITLE: NCI Community Oncology Research Program (NCORP) Minority/Underserved Community Sites


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biotechnology;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Lung;Pediatric;Pulmonary Hypertension;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Pulmonary arterial hypertension (PAH) is rare in the neonatal and pediatric population, but affected patients suffer from substantial morbidity and mortality. Currently available therapies target the imbalance of vasoconstrictive and vasodilatory endothelial signals present in most patients, but there are few modalities that address the underlying pathologic origins of disease. The research in this proposal will help lead to better understanding of disease biology as it relates to specific etiologies and stages of the disease, creating an opportunity for more focused therapies in children.

PI_NAMEs: BOEHME, JASON  (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Address;advanced disease;Affect;Anabolism;Animal Model;Animals;Biochemical;Biological;Biological Markers;Biology;Bioreactors;Blood flow;Blood Vessels;carboxylation;career;Catabolism;Cell Culture Techniques;cell growth;Cell Line;Cell Proliferation;Child;Childhood;Cholesterol;cholesterol biosynthesis;Cholesterol Homeostasis;Circulation;clinically relevant;comparison control;congenital heart abnormality;Data;Disease;disease model;Disease Progression;Endothelium;Enzymes;Etiology;Evaluation;Exhibits;experience;Exposure to;Genetic;Genetic Transcription;Glucose;Glutamate Metabolism Pathway;Glutamine;Goals;Growth;hemodynamics;inhibitor;knock-down;Knowledge;Label;Lead;Lung;mechanical stimulus;Medial;Membrane Transport Proteins;Metabolic;Metabolism;Microfluidics;Mitochondria;Modality;Modeling;Monitor;Morbidity - disease rate;mortality;muscle metabolism;Neonatal;new therapeutic target;novel;Nuclear;Operative Surgical Procedures;Pathologic;Pathway interactions;Patients;pediatric patients;pharmacologic;Phase;Phenotype;Physiological;Play;Population;pre-clinical;pressure;Process;Proliferating;Publishing;pulmonary arterial hypertension;Pulmonary artery structure;pulmonary vascular disorder;Purines;Refractory;Research;Respiration;response;Risk;Role;Secondary to;Serum;Severity of illness;Shunt Device;Signal Transduction;skills;Smooth Muscle;Smooth Muscle Myocytes;stable isotope;stem;Structure;Supplementation;targeted treatment;Testing;Therapeutic Intervention;therapeutic target;Transcriptional Activation;Transcriptional Regulation;translational model;vascular abnormality;Vascular Diseases;Vascular Smooth Muscle;Work

PROJECT_TITLE: Pulmonary vascular glutamine metabolism at the intersection of hemodynamic forces and smooth muscle proliferation in congenital heart disease


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Immunotherapy;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Survival studies show marked racial disparity effect in head and neck cancer between African Americans and Non-Latinx Whites (Whites). This project explores how key racial differences in genetic changes during the progression of HNSCC impact the expression of key immunomodulatory cytokines or ligands within the tumor microenvironment in order to escape an antitumor immune response. This molecular mapping will provide crucial insights that have significant implications for risk assessment, tumor surveillance and treatment interventions for oral cancer tumors in African American patients.

PI_NAMEs: SIDRANSKY, DAVID  (contact);TOLAND, AMANDA EWART

PROGRAM_OFFICER_NAME: WANG, WENDY

PROJECT_TERMS: advanced disease;Affect;African American;African American population;Age;anti-tumor immune response;bioinformatics tool;Biological;Biological Factors;Biopsy;cancer invasiveness;carcinogenesis;CD8B1 gene;CDKN2A gene;cell mediated immune response;Cells;Clinical;Computer Analysis;cytokine;Data;Death Rate;Demographic Factors;design;Development;Disease;disorder risk;DNA;Dysplasia;Early Diagnosis;Event;Evolution;exhaustion;exome;exome sequencing;extracellular;FGFR1 gene;Genetic;genomic profiling;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;health care availability;Heterogeneity;Histologic;HPV negative;HPV positive;Human;Human papilloma virus infection;Immune;Immune checkpoint inhibitor;Immune response;Immune system;Immune System Diseases;Immune Tolerance;Immunogenetics;Immunologic Surveillance;Immunophenotyping;immunoregulation;improved;in vitro Model;Inherited;insight;interest;Intervention;Invaded;Knowledge;Lead;Lesion;Lesion by Stage;Leucocytic infiltrate;Leukoplakia;Ligands;Link;Location;Low Prevalence;Malignant - descriptor;malignant mouth neoplasm;Malignant Neoplasms;Maps;Methods;Molecular;mouth squamous cell carcinoma;Mutation;Mutation Analysis;neoplastic;neoplastic cell;Oral cavity;oral lesion;Oral Stage;oral tumorigenesis;Outcome;outcome disparities;Pathway interactions;Patients;Pattern;PIK3CA gene;Population;premalignant;Premalignant Cell;Preneoplastic Conditions;Primary Neoplasm;Prognosis;prognostic;progression risk;racial difference;racial disparity;racial population;RAS genes;Recurrence;Regulatory T-Lymphocyte;Resected;Resolution;Risk Assessment;risk prediction;RNA;Role;Sampling;Severe dysplasia;Shapes;Socioeconomic Status;Somatic Mutation;survival disparity;T-Lymphocyte;targeted treatment;The Cancer Genome Atlas;Therapeutic Intervention;therapeutic target;Time;Tissues;TP53 gene;transcriptome sequencing;tumor;tumor microenvironment;tumor progression;Tumor stage;tumor-immune system interactions;tumorigenesis;Visual

PROJECT_TITLE: Racial differences in Immunogenetic Tumorigenesis of Head and Neck Squamous Cell Carcinoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Y(55)R]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: LOS ANGELES

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The proposed project seeks to elucidate the novel interaction between Nell-1, a unique osteogenic protein with proven potency for bone regeneration, and its receptor, Cntnap4, a presynaptic membrane protein that has functional association with autism spectrum disorder (ASD). We anticipate that the outcomes of the project will greatly improve our knowledge of Nell-1's function in both the skeletal and nervous system. This, in turn, may translate into the development of better treatment options for patients with craniofacial bone anomalies or neural conditions such as ASD.

PI_NAMEs: SOO, CHIA  (contact);ZHANG, XINLI

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Adult;Agonist;autism spectrum disorder;Behavior;Behavior assessment;Behavioral;beta catenin;Binding;bone;Bone Growth;bone healing;Bone Regeneration;bone repair;Brain;brain tissue;Breeding;Calvaria;Cell surface;Cells;Cephalic;comparative;craniofacial;craniofacial bone;Craniosynostosis;Data;Defect;Development;Drug or chemical Tissue Distribution;Embryo;Ethylnitrosourea;Event;Exhibits;Fiber;Frontal bone structure;GABA Agonists;gamma-Aminobutyric Acid;glycogen synthase kinase 3 beta;Goals;Growth and Development function;healing;Histology;Human;improved;inhibitor;Integrins;Interneurons;Intervention;Knock-out;Knockout Mice;Knowledge;Ligands;Link;LoxP-flanked allele;Measurement;Mediating;member;Membrane;Membrane Proteins;microCT;Molecular;Morphology;Mus;Mutant Strains Mice;Natural regeneration;Neonatal;Nervous System;neural;Neural Crest Cell;neurological pathology;Neurons;novel;novel therapeutics;Osteoblasts;Osteogenesis;osteogenic;osteogenic protein;Outcome;Output;overexpression;Parietal bone structure;Parvalbumins;Pathogenesis;Patients;Phosphorylation;postnatal;premature;presynaptic;Process;Property;Proteins;receptor;repaired;Role;Sensory Ganglia;Signal Transduction;skeletal;Skeletal Development;Skeletal system;skeletal tissue;spatiotemporal;Specific qualifier value;Structure of trigeminal ganglion;suture fusion;Synaptic Transmission;Testing;Therapeutic;Tissues;Transgenic Organisms;Translating;transmission process;Wild Type Mouse;WNT Signaling Pathway

PROJECT_TITLE: Dual roles of Nell-1 in craniofacial bones and brain through interaction with Cntnap4

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;HIV/AIDS;Human Genome;Immunotherapy;Infectious Diseases;Prevention;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: BRONX

ORG_DEPT: PATHOLOGY

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative Our study explores the impact of HIV and oral HPV infection on the immune response in oropharyngeal cancer. Specifically, we will examine how CD8+ T cells, essential for combating viruses and tumors, are influenced by HIV-HPV co-infection. The results aim to improve prevention, diagnosis, and treatment approaches for HPV- positive oropharyngeal cancer patients, especially those living with HIV, with broader implications for other HPV- related malignancies.

PI_NAMEs: GOLDSTEIN, HARRIS ;YIN, SHANYE  (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: 3' Untranslated Regions;Affect;Antigens;antiretroviral therapy;antiviral immunity;Avidity;Bar Codes;Biological Assay;Cancer Patient;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Chronic;Clinical;co-infection;Coupled;Cytokine Signaling;Development;Diagnosis;Ensure;exhaust;exhaustion;Face;Functional disorder;General Population;Genes;genetic signature;global health;Goals;high risk;HIV;HIV Infections;HIV/AIDS;HPV oropharyngeal cancer;Human papilloma virus infection;human papilloma virus oropharyngeal squamous cell carcinoma;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Immune;immune checkpoint blockade;Immune Evasion;immune function;Immune response;Immune system;Impairment;improved;In Vitro;Incidence;Incubated;Individual;Infiltration;Inflammation;innovation;insight;malignant oropharynx neoplasm;Maps;Modeling;mouse model;Neoplasms;novel;novel therapeutic intervention;Opportunistic Infections;oral HPV infection;Oropharyngeal Squamous Cell Carcinoma;Outcome;Pathway interactions;Patients;Persons;Phenotype;Play;Population;Predisposition;Prevalence;prevent;Prevention;Primary Neoplasm;programmed cell death ligand 1;Public Health;Reporting;Research;Role;Sampling;single cell analysis;single cell sequencing;single-cell RNA sequencing;Specificity;Squamous cell carcinoma;T cell receptor repertoire sequencing;T-Cell Receptor;T-Lymphocyte;treatment strategy;tumor;Tumor Antigens;tumor microenvironment;tumor progression;tumor specificity;Tumor-Infiltrating Lymphocytes;Viral Antigens;Virus;Virus Diseases;Yin

PROJECT_TITLE: Dissecting Tumor-Immune Interactions in HIV-HPV Co-Infection-Associated Oropharyngeal Cancer using Single Cell Sequencing and Novel Mouse Models

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 CC (10)]


ADMINISTERING_IC: HD

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Complementary and Integrative Health;Disability Research;Networking and Information Technology R&D (NITRD);Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: NEW YORK

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: PROJECT NARRATIVE New technologies are needed to address the limited availability of rehabilitation therapy as well as the suboptimal functional outcomes for people with hand impairments after stroke. This project will investigate a patient-centered approach to reinforce neuromuscular coordination and usage of the impaired limb through the use of surface- electromyography biofeedback and robot-assisted motor training. This study has the potential to combine rehabilitative and functional assistance within a mobile platform, and could close the gap between quantitative assessments of motor function and the user’s perception of performance in real-world tasks.

PI_NAMEs: CHEN, AVA  (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: Address;Adoption;Algorithms;Area;arm;arm paresis;Biofeedback;Biofeedback Training;Chronic;chronic stroke;Clinic;clinical efficacy;Collaborations;Complication;Data;Detection;Development Plans;Devices;Discrimination;electromyographic biofeedback;Electromyography;Engineering;Exercise;exoskeleton;experimental study;Extensor;Feedback;fighting;Flexor;Forearm;functional assistance;functional outcomes;Generations;Goals;grasp;Hand;hand dysfunction;hand rehabilitation;hand therapy;hemiparesis;Human;Impairment;Improve Access;improved;Individual;insight;interest;Intervention;Intuition;Laboratories;Laboratory Research;Lifting;Limb structure;Measures;Mediating;Mentors;Methods;mobile computing;Monitor;Motor;motor control;motor learning;motor skill learning;Movement;movement practice;Muscle;Muscle Contraction;muscle stiffness;Nervous System Disorder;Neurologic;Neurological outcome;neuromuscular;new technology;Occupational Therapist;Orthotic Devices;Outcome;Paresis;patient oriented;Patients;Pattern;Perception;Performance;Persons;physical therapist;Physical therapy;post intervention;post stroke;Process;Protocols documentation;Psychological reinforcement;Quality of life;recruit;Regimen;Rehabilitation therapy;Research;response;Robot;robot assistance;robot control;robot exoskeleton;robotic device;robotic system;robotic training;Robotics;sensor;Series;Signal Transduction;Skeletal Muscle;spasticity;Stroke;stroke hemiparesis;stroke rehabilitation;stroke survivor;Surface;synergism;System;Techniques;Testing;Therapeutic;Therapeutic Effect;therapy outcome;Time;Training;Translational Research;upper limb hemiparesis;Visual;wearable device;Work

PROJECT_TITLE: Impact of biofeedback and task-specific training with a robotic hand orthosis on voluntary muscle modulation for rehabilitation post-stroke


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Black women in Georgia bear a disproportionate burden of the U.S. maternal health crisis with alarmingly high maternal morbidity and mortality rates. Very few studies have investigated the multifaceted ways that structural racism drives disparities in maternal morbidity and mortality for this population. The proposed mixed-methods and multi-level study aims to leverage population-level vital records and administrative data as well as physician and patient perspectives to document novel, potentially modifiable, structural associations elucidating the relationship between structural racial discrimination and severe maternal morbidity among Black women in GA that can inform future systems-level interventions.

PI_NAMEs: BOULET, SHEREE L (contact);CARTER, SIERRA E

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Address;adverse maternal outcomes;Affect;aged;Attitude;Bayesian Modeling;Behavior;Belief;Birth;Black race;black women;black/white disparity;Caring;Chronic;Chronic stress;Color;Communities;Complex;Conscious;coping;County;Criminal Justice;critical period;Crows;Data;Data Analyses;Death Rate;Dehumanization;Discipline of obstetrics;Discrimination;disparities in morbidity;Disparity;Economics;Education;Employment;experience;Focus Groups;Future;Goals;healing;Health;Health behavior;health belief;health care availability;health care quality;health disparity;health inequalities;Health Insurance;Health Status;Health system;Healthcare;Healthcare Systems;Hospitals;Housing;Hypertension;Income;Individual;Inequity;infant outcome;insight;Institution;Institutional Racism;intergenerational;intersectionality;Intervention;Laws;Life Cycle Stages;Link;Literature;Lived experience;long-standing disparities;Maternal Health;maternal morbidity;Maternal Mortality;maternal outcome;Measures;Medical;Mental Depression;Methods;Modeling;novel;Online Systems;organizational climate;Outcome;Patients;Perception;Perinatal mortality demographics;Persons;Physicians;Physiological;Policies;Politics;poor sleep;Population;post pregnancy;Postpartum Period;Pregnancy;Pregnancy Complications;pregnancy related death;pregnant;Premature Birth;Process;promote resilience;Provider;psychological stressor;Qualitative Methods;Race;racial discrimination;racial disparity;Racial injustice;racism;Reaction;Records;reproductive;Research;resilience;Respondent;Risk;severe maternal morbidity;Slave;social;Social Behavior;socioeconomics;Stress;structural determinants;Structural Racism;Structure;Surveys;Symptoms;System;theories;Time;War;White Women;Woman

PROJECT_TITLE: Investigating structural maternal health inequities among Black reproductive aged women in Georgia: a  mixed methods and multi-level approach


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: PARKTOWN

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: WITS HEALTH CONSORTIUM (PTY), LTD

PHR: HE2AT Center Overall - Project Narrative The Heat and Health African Transdisciplinary Center (HE2AT Center) will generate new knowledge on the impacts of heat waves and extreme heat on clinical conditions and on people living in vulnerable urban settings, applying data sciences approaches to existing environmental and high-quality health outcomes data. Perhaps more importantly, the Center will develop and test innovative solutions for tracking heat-related conditions at a district level and for providing individualized early warnings of dangerous heat periods relevant to high-risk groups, industry and the general population. In all Center activities we will build capacity of the team and key organizations, engage with communities, government and other stakeholder, and work across the DS-I Africa Program.

PI_NAMEs: CHERSICH, MATTHEW FRANCIS (contact);LUCHTERS, STANLEY

PROGRAM_OFFICER_NAME: NEWSOME, BRAD

PROJECT_TERMS: Address;Adopted;Africa;Africa South of the Sahara;African;Air;Basic Science;Behavioral;Behavioral Sciences;Biometry;Birth Weight;built environment;burden of illness;career;Centers for Disease Control and Prevention (U.S.);Characteristics;Climate;climate change;climate crisis;climate data;climate impact;climate-related health;Climatology;Clinical;Clinical Medicine;cohort;Collaborations;community engagement;complex data;computer science;computer scientist;Dangerousness;Data;Data Analyses;data ecosystem;data management;data platform;data repository;data reuse;Data Science;Data Scientist;Data Sources;Development;digital applications;Disease;doctoral student;Ecosystem;Elements;Environmental Exposure;Event;extreme heat;Future;General Population;Geography;global temperature;Goals;Government;hazard;Health;health data;health goals;Health Sciences;Heat Waves;high risk;high risk population;Housing;Individual;Industrialization;Industry;Influentials;innovation;Institution;interest;Ivory Coast;Knowledge;Link;Low income;Machine Learning;machine learning algorithm;maternal outcome;Morbidity - disease rate;mortality;neonatal outcome;neonate;Outcome;Output;Participant;Persons;Pilot Projects;Planets;Policies;Pre-Eclampsia;Pregnant Women;Premature Birth;Preparation;programs;prospective;Public Health;Research;Research Activity;Research Priority;Research Project Grants;Resources;response;Risk;Risk Factors;risk prediction;Scientist;Series;social;Social Sciences;Software Design;South Africa;Specificity;statistics;System;Techniques;Technology;Temperature;Testing;Time;Training;Training Support;United States;Universities;urban area;urban setting;Vertebral column;Vulnerable Populations;Weather;Work

PROJECT_TITLE: Developing data science solutions to mitigate the health impacts of climate change in Africa: the HE2AT Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-S(70)R]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: HIV/AIDS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Nationally, sexual and reproductive health indicators lag behind those of other developed countries, with striking disparities in maternal health. Gender and sexual minorities confront disproportionate physical and mental health risks. Globally, the burden of disease and death associated with HIV, sexually transmitted infections, and maternal and infant mortality represents an urgent problem. This proposal requests continued funding for a rigorous doctoral program with an outstanding record of success in training young scholars in the methodological and analytical skills needed to conduct high-impact research on these critical public health issues.

PI_NAMEs: HIRSCH, JENNIFER S (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Grant;Training

PROJECT_TITLE: GSH Training Grant


NIH_SPENDING_CATS: Pediatric

ORG_CITY: BOSTON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative Significant advances have been made in reproductive, perinatal, and pediatric (RPP) epidemiologic research over the last several decades. However, important challenges remain to deepen our understanding of the critical periods of risk, identify determinants, elucidate mechanisms, investigate outcomes, and determine their impact on health and disease across the life course. The Training Program in Reproductive, Perinatal, and Pediatric (RPP) Life Course Epidemiology addresses this challenge by preparing the next generation of life course-oriented, cutting-edge, innovative, transdisciplinary researchers who will serve as independent investigators equipped to advance our understanding of significant RPP health research, apply cutting-edge evidence to inform clinical practice, translate science into policy action, and implement prevention strategies to improve the health of women and children across the reproductive life course.

PI_NAMEs: HERNANDEZ-DIAZ, SONIA ;TIEMEIER, HENNING  (contact)

PROJECT_TERMS: Childhood;Life course epidemiology;Perinatal;reproductive;Training Programs

PROJECT_TITLE: The Training Program in Reproductive, Perinatal, and Pediatric Life Course Epidemiology


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Hepatitis;Liver Disease;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Alcoholic hepatitis is a disease of intense liver inflammation and injury caused by heavy alcohol use that can be deadly when severe. Cytokine IL17 may contribute to the development of alcoholic hepatitis by stimulating liver sinusoidal endothelial cells (LSECs) to produce chemokines that drives the inflammatory response. In this study, we will explore the mechanisms of IL17-mediated LSEC activation in alcoholic hepatitis and experiment with novel ways of inhibiting IL17 production by targeting a gene regulatory element.

PI_NAMEs: LIU, MENGFEI  (contact)

PROGRAM_OFFICER_NAME: LIN, LI

PROJECT_TERMS: Affect;alcohol abuse therapy;Alcoholic Hepatitis;Alcoholic Liver Diseases;Autoimmune;Biological;Biological Assay;Blood Vessels;Cells;chemokine;Chemotaxis;Chromatin Conformation Capture and Sequencing;chromatin immunoprecipitation;chromosome conformation capture;Circulation;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CXCL1 gene;cytokine;Data;Development;Discontinuous Capillary;Disease;DNA;Dominant-Negative Mutation;Endothelial Cells;Endothelium;Enhancers;experimental study;Family;Gene Expression;gene network;Genes;Genome;Guide RNA;Heavy Drinking;Hereditary Disease;IL17 gene;Immune;immune activation;immune cell infiltrate;in vivo;Infiltration;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Interleukin Suppression;Knock-in;Knock-in Mouse;Knockout Mice;Knowledge;Ligands;Liver;liver inflammation;liver injury;Liver parenchyma;Mediating;member;Microfluidic Microchips;migration;Mission;Modeling;Molecular Target;mouse model;Mus;National Institute on Alcohol Abuse and Alcoholism;neutrophil;Neutrophil Infiltration;new therapeutic target;novel;novel therapeutics;Nuclear;paracrine;Paracrine Communication;Pathogenesis;Pathway Analysis;Pathway interactions;Patients;pharmacologic;Phosphorylation;Process;Production;promoter;Protein Isoforms;Regulation;Regulatory Element;response;Role;Signal Pathway;Signal Transduction;Small Interfering RNA;Source;synergism;System;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Testing;therapeutic target;Threonine;Tissues;TNF gene;transcription factor;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Transgenic Mice;Up-Regulation;Variant;Viral;Work

PROJECT_TITLE: IL17 dependent angiocrine signaling drives inflammation in alcohol associated hepatitis

STUDY_SECTION: AA

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


ORG_CITY: PORTLAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Our work has pioneered efforts to evaluate the contribution of contact activation to the progression of vascular device-related blood clotting. Despite the use of currently available “blood thinning” drugs, which all have dose-limiting bleeding side effects, aberrant activation of the contact pathway of blood coagulation causes device failures, and contributes to significant vascular device-associated morbidity and mortality. The research will generate new knowledge supporting the development of novel anticoagulants that are significantly safer, lack dose-limiting toxicity, and cause less bleeding than current drugs while helping to identify medical conditions that could benefit from the therapeutic use of these contact activation inhibitors.

PI_NAMEs: HINDS, MONICA T;MCCARTY, OWEN J (contact)

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: Animal Model;Antibodies;Anticoagulant therapy;Anticoagulants;Anticoagulation;Antiplatelet Drugs;Back;Basic Science;Biochemical;biomaterial interface;Biophysical Process;Blood;Blood coagulation;Blood Coagulation Factor;Blood flow;Blood Platelets;Blood Vessels;Brain hemorrhage;Cardiovascular system;Clinical;Clinical Trials;Clinical Trials Design;Coagulation Process;combinatorial;Contact Inhibition;Critical Illness;Data;Death Rate;Dedications;Deposition;design;Development;Devices;Dose Limiting;efficacy evaluation;End stage renal failure;Equipment Malfunction;Event;experience;Exposure to;Extracorporeal Membrane Oxygenation;Failure;Fibrin;Fibrinolytic Agents;Future;gastrointestinal;Generations;Grant;Growth;Hemodialysis;Hemorrhage;Hemostatic Agents;Heparin;Impairment;improved;improved outcome;In Vitro;in vitro Model;in vivo;Incidence;inhibitor;Interruption;Intervention;Kininogenase;Knowledge;Legal patent;Lung;Marketing;Medical;Medical Device;Medicine;member;Membrane Oxygenators;Modeling;Molecular;Molecular Target;Morbidity - disease rate;mortality;Neonatal;neonate;novel;Organ;Oxygenators;Pathologic;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phase II Clinical Trials;Plasma Kallikrein;Platelet Activation;Platelet Count measurement;platelet function;pre-clinical;Preclinical Testing;Prekallikrein;prevent;Prevention;programs;Pump;Recombinants;Research;Risk;Role;Safety;Severities;side effect;small molecule inhibitor;Stents;Surface;System;Therapeutic;Therapeutic Uses;Thrombin;Thrombosis;thrombotic;thrombotic complications;Thrombus;Toxic effect;Translating;Tube;validation studies;Work

PROJECT_TITLE: Contact Pathway Activation on Vascular Devices

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-B(02)M]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: PROJECT NARRATIVE  Many laboratory studies in both rodents and non-human primates consistently have shown large cognitive-enhancing effects of dopamine D1 agonists that are greater than current therapies for age-related cognitive decline such as cholinesterase inhibitors and memantine for Alzheimer’s disease. We propose to study how the mechanism of receptor functional selectivity/biased signaling may allow discovery of novel and superior drugs based on their pattern of differential activation of D1 dopamine receptor signaling pathways. The experiments are designed to lead to a highly promising compound that could translate into a novel therapeutic with profound cognitive benefits.

PI_NAMEs: DOKHOLYAN, NIKOLAY ;MAILMAN, RICHARD B;YANG, YANG  (contact)

PROGRAM_OFFICER_NAME: GROTHAUS, PAUL G

PROJECT_TERMS: Acceleration;Address;Affect;age effect;Age-associated memory impairment;aged;Aging;Agonist;Alzheimer's Disease;Animal Model;Behavior;Behavioral;beta-arrestin;Binding;Biological Assay;brain tissue;Cholinesterase Inhibitors;clinical development;Clinical Research;Clinical Trials;Cognition;Cognitive;cognitive benefits;cognitive enhancement;cognitive function;cognitive process;Computing Methodologies;Corpus striatum structure;Coupling;Cyclic AMP;Cytoplasm;Data;Dementia;Disease;Dopamine;Dopamine Agonists;Dopamine D1 Receptor;Drug Binding Site;drug discovery;druggable target;Elderly;Experimental Designs;experimental study;flexibility;Foundations;Future;GTP-Binding Proteins;Health;heuristics;Hippocampus;Human;improved;in silico;In Vitro;in vivo;Intervention;Laboratories;Laboratory Study;Lead;Lesion;Ligands;Literature;Mediating;Memantine;memory recognition;Molecular;Motor;Mus;National Institute of Mental Health;Neurons;neurophysiology;Neurosciences;next generation;nonhuman primate;novel;novel therapeutics;Pattern;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pharmacology;Physiological;Physiology;Play;Prefrontal Cortex;primary endpoint;Primates;programs;Property;Quality of life;Rattus;receptor;receptor binding;Regulation;Resolution;response;Rodent;Role;Short-Term Memory;Signal Pathway;Signal Transduction;simulation;skills;Societies;Synaptic plasticity;System;Testing;Transgenic Organisms;Translating;Work;young adult

PROJECT_TITLE: Discovery of functionally selective dopamine ligands for age-related cognitive decline

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS-R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: TAMPA

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Project Narrative Alzheimer’s disease and Alzheimer’s disease-related dementias, a group of age-associated disorders characterized by progressive deterioration of brain function, affect millions of people in the US. This proposal investigates how loss of pericytic laminin leads to neurovascular dysfunction (blood brain barrier disruption, cerebral blood flow reduction, and brain influx/efflux function impairment) and neurodegeneration, and explores the underlying molecular mechanisms. Successful completion of this study will elucidate the fundamental roles of pericytic laminin in neurovascular function and neurodegeneration, and identify novel molecular targets with therapeutic potential in Alzheimer’s disease and Alzheimer’s disease-related dementias.

PI_NAMEs: YAO, YAO  (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Affect;Age;age group;age related;age related neurodegeneration;age-related disease;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid beta-Protein;Astrocytes;Basement membrane;Biochemical;Biological Assay;Biological Process;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier disruption;Brain;Cells;Cerebrovascular Circulation;cognitive disability;conditional knockout;Defect;Dementia;Deposition;Deterioration;Development;effective therapy;Endothelial Cells;Endothelium;Extracellular Matrix Proteins;fluorescein isothiocyanate dextran;Functional disorder;Generations;Human;Image;Impaired cognition;Impairment;In Vitro;in vivo;innovation;Knockout Mice;Label;Laboratories;Laminin;laminin S;macromolecule;Maintenance;Mediating;Mission;Molecular;Molecular Target;Molecular Weight;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;neuron loss;Neuronal Injury;neuronal survival;Neurons;neurovascular;neurovascular unit;novel;Pathogenesis;Perfusion;Pericytes;Persons;Protein Isoforms;Proteins;Quantitative Autoradiography;receptor;Research;Rodent;Role;Smooth Muscle Myocytes;Structure;Testing;Therapeutic;Thick;two photon microscopy;two-photon;Vascular Smooth Muscle

PROJECT_TITLE: The roles of pericyte-derived laminin in neurovascular function and neurodegeneration


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE  APOE4 is the strongest genetic risk factor for late-onset Alzheimer's disease, for which brain energy deficit is an event emerging in its prodromal phase. The proposed program of research addresses the role of APOE4 in regulating the energy producing system of the brain. Outcomes of this research will further the understanding of the complexities underlying APOE4-driven Alzheimer’s risks, and identify potential therapeutic targets and opportunities to prevent or delay the course of developing Alzheimer’s disease.

PI_NAMEs: YIN, FEI  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Address;Affect;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;apolipoprotein E-3;Astrocytes;Bioenergetics;Biology;Brain;brain cell;cell type;Cells;Coculture Techniques;Complex;Coupling;design;Development;Disease;Early Onset Alzheimer Disease;Environmental Risk Factor;Equilibrium;Etiology;Event;fatty acid metabolism;Fatty Acids;Functional disorder;functional outcomes;Genetic Polymorphism;Genetic Risk;genetic risk factor;Genotype;glucose metabolism;Health;Heterogeneity;Homeostasis;Impaired cognition;Impairment;In Vitro;in vivo;Inflammatory;Investigation;Knowledge;Late Onset Alzheimer Disease;lipid metabolism;Lipids;Mediating;Metabolic;metabolic phenotype;metabolic profile;Metabolism;Mitochondria;mitochondrial dysfunction;Modeling;Modification;Molecular;mouse model;Mus;Neurodegenerative Disorders;Neuroglia;neuroinflammation;Neuronal Dysfunction;Neurons;novel;Outcome;Outcomes Research;oxidation;Oxidation-Reduction;Oxidative Phosphorylation;Pathway interactions;Phase;Phenotype;preference;prevent;programs;Protein Isoforms;Regulation;Reporting;Research;resilience;restoration;Risk;Role;single nucleus RNA-sequencing;Synapses;System;Testing;Therapeutic;therapeutic target;transcriptomics;Variant

PROJECT_TITLE: APOE Regulation of Neuron-Astrocyte Metabolic Coupling in Alzheimer's Disease

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Treatments for Alzheimer's disease will likely be most eﬀective if applied before patients begin to develop symptoms of cognitive decline. But clinical trials in individuals who do not yet have any symptoms of disease can take a very long time and be very costly. This project uses common magnetic resonance imaging exams and artiﬁcial intelligence tools to detect subtle changes over time in parts of the brain where damage speciﬁcally due to Alzheimer's disease ﬁrst occurs, providing clinical trials with a faster way to determine if treatments are being eﬀective.

PI_NAMEs: WOLK, DAVID A;YUSHKEVICH, PAUL A. (contact)

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: 3-Dimensional;Acceleration;Accounting;Affect;Algorithms;alpha synuclein;Alzheimer associated neurodegeneration;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Anatomy;Area;arm;Artificial Intelligence;Atlases;Autopsy;Biological;Biological Markers;Blood Vessels;Brain;Brain Injuries;brain magnetic resonance imaging;Brain region;Brodmann's area;Cerebrovascular Disorders;Clinical;Clinical Trials;Cognitive;cognitive testing;cohort;computational atlas;Computational Technique;Computer Analysis;Conduct Clinical Trials;cost;Data;deep learning;deep learning algorithm;Detection;digital pathology;Disease;disease heterogeneity;Disease Progression;empowerment;Exhibits;experimental arm;Failure;Future;Goals;Head;Heterogeneity;high risk;Histology;Image;Image Analysis;imaging modality;Impaired cognition;improved;in vivo;Individual;Industry;Investments;Life;Link;Liquid substance;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Maps;Measurement;Measures;Medial;medial temporal lobe;Methodology;Modeling;Morphologic artifacts;Motion;MRI Scans;multi-atlas segmentation;Nerve Degeneration;Neurobehavioral Manifestations;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroimaging;neuron loss;novel;Participant;Pathologic;Pathology;Patients;Pattern;Phase;Phase II Clinical Trials;Phase III Clinical Trials;phase III trial;Placebos;Positron-Emission Tomography;pre-clinical;protein TDP-43;Protocols documentation;recruit;Research;Resolution;Resources;Scanning;screening;Sensitivity and Specificity;serial imaging;Serial Magnetic Resonance Imaging;Shapes;Site;Slide;Statistical Data Interpretation;Symptoms;Synapses;synucleinopathy;tau aggregation;tau Proteins;Tauopathies;Techniques;Temporal Lobe;Testing;Thick;Time;tool;Translating;Treatment Effectiveness;Treatment Efficacy;Work

PROJECT_TITLE: Improving the sensitivity and specificity of MRI-based biomarkers in Alzheimer's disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative - This proposal aims to develop and validate sex- and APOE-specific network models of Alzheimer’s disease (AD) for discovery of novel pathways, targets and therapeutics for AD by performing integrative multiscale network analysis of large-scale bulk and single multi-omics data. A number of predicted targets, network models and drugs will be validated using human iPSC-derived brain cell cultures and AD mouse models.

PI_NAMEs: CAI, DONGMING ;ZHANG, BIN  (contact)

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: 3-Dimensional;Algorithms;Alleles;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;Alzheimer's disease therapeutic;Apolipoprotein E;apolipoprotein E-4;ATAC-seq;Basic Science;Biology;Brain;brain cell;Brain region;candidate identification;causal variant;Cell Culture Techniques;Cell Nucleus;cell type;Cells;Chronic;Clinical;Clinical Research;Clinical Trials;Coculture Techniques;Cognitive deficits;cohort;comparison control;Complex;Computerized Medical Record;Data;Data Set;Databases;Development;Diagnostic;Disease;disorder control;drug candidate;drug repurposing;drug use screening;Essential Genes;Etiology;FDA approved;Future;Gene Expression Regulation;gene repression;Genes;Genetic;genetic manipulation;genetic risk factor;genetic variant;Genotype;Hippocampus;human disease;human induced pluripotent stem cells;insight;Intervention;Methods;Microinjections;Molecular;Molecular Profiling;molecular scale;mouse model;Multiomic Data;multiple drug use;multiple omics;Mus;network models;neuroimaging;neuropathology;novel;Pathogenesis;Pathologic Processes;Pathology;Pathway Analysis;Pathway interactions;Pharmaceutical Preparations;pharmacologic;research study;Risk;sex;Sex Preselection;sexual dimorphism;single nucleus RNA-sequencing;single-cell RNA sequencing;Subgroup;System;Systems Biology;Therapeutic;Therapeutic Intervention;Therapeutic Uses;Tissues;transcriptome;transcriptome sequencing;transcriptomics;treatment response;Up-Regulation;Validation;Variant;virtual;virtual clinical trial

PROJECT_TITLE: Dissect the interplay between sex and APOE at the single cell level to uncover novel pathways, targets and therapeutics for Alzheimer's disease


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: New York

ORG_NAME: ACTINIUM PHARMACEUTICALS, INC.

PHR: NARRATIVE Certain resistant forms of leukemia and lymphoma may be treated with a combination of chemotherapy and tumor-targeted immunotherapy made by modifying a patient’s own immune cells (CD19-targeted CAR T-cell therapy), but serious side effects including a spectrum of neurological toxicities known as ICANS and a serious inflammatory reaction known as CRS occur in a significant percentage of patients. White blood cells called monocytes secrete the signal molecules (cytokines) that initiate the inflammatory cascade leading to ICANS and CRS; therefore, giving a treatment to eliminate monocytes before CAR T-cell therapy (instead of chemotherapy) may decrease the risk of serious side effects. Actinium herein proposes a clinical trial, to be conducted at Memorial Sloan Kettering Cancer Center, evaluating the use of a radioisotope-linked antibody targeting monocytes and other immune cells (CD45-targeted antibody drug conjugate, iodine 131 [131-I] apamistamab), in place of chemotherapy, to help make CAR T-cell treatment safer and more effective for patients with resistant blood cancers.

PI_NAMEs: DESAI, AVINASH  (contact);GEYER, MARK B

PROGRAM_OFFICER_NAME: WEBER, PATRICIA A

PROJECT_TERMS: Actinium;Acute Myelocytic Leukemia;Address;Adopted;Adoptive Cell Transfers;Adult;aged;Antibodies;Antibody-drug conjugates;Autologous;B-Cell Acute Lymphoblastic Leukemia;Behavior Therapy;Biodistribution;Blood;Bone Marrow;cancer cell;CD19 Antigens;CD19 gene;CD28 gene;Cells;Cerebral Edema;Cerebrospinal Fluid;chemotherapy;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clinical Research;Clinical Trials;cohort;Combination Drug Therapy;commercialization;conditioning;Correlative Study;Cyclophosphamide;cytokine;cytokine release syndrome;design;Development;Dose;dosimetry;Dysphasia;Encephalopathies;experience;fludarabine;Generations;Hematologic Neoplasms;Hematopoietic;Hematopoietic Neoplasms;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;high risk;I131 isotope;Immune;immune effector cell-associated neurotoxicity syndrome;immunoregulation;Immunotherapy;improved;In complete remission;Incidence;Inflammatory;Infusion procedures;Interleukin-1;Interleukin-6;Investigation;Kinetics;Label;large cell Diffuse non-Hodgkin's lymphoma;Lead;leukemia/lymphoma;Leukocytes;Link;Lymphocyte;Lymphocyte Count;Lymphocyte Depletion;Maximum Tolerated Dose;Memorial Sloan-Kettering Cancer Center;monocyte;multimodality;Myeloid-derived suppressor cells;Myelosuppression;Neurologic;Non-Hematologic Malignancy;novel strategies;participant enrollment;patient population;patient subsets;Patients;Peripheral;peripheral blood;Phase;Pre-Clinical Model;preclinical study;preservation;Prior Chemotherapy;Prognosis;PTPRC gene;Radioisotopes;Radiolabeled;Radiopharmaceuticals;Reaction;Recovery;Refractory;Regimen;Regulatory T-Lymphocyte;Relapse;Reporting;Resistance;response;Risk;Risk Reduction;Safety;safety and feasibility;Seizures;side effect;Signaling Molecule;Source;Structure;T cell therapy;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Toxic effect;Transplantation Conditioning;tumor

PROJECT_TITLE: Iomab-ACT: A phase I/II study of 131-I apamistamab targeted lymphodepletion followed by CD19-targeted CAR T-cell therapy for patients with relapsed or refractory B-ALL or DLBCL

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-R(11)B]