ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Epilepsy;Mental Health;Mental Illness;Neurodegenerative;Neurosciences

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE Depression is a serious public health problem whose biological basis remains unknown. Here, we use a new technology to directly measure dopamine and serotonin, neurotransmitters thought to be central in depression, in awake individuals with and without depression as they undergo depth electrode monitoring for epilepsy. In order to make significant advances in understanding and developing novel therapies for the disorder, directly and accurately studying neuromodulator responses in humans is required.

PI_NAMEs: CHIU, PEARL H (contact);MONTAGUE, P READ

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Affective;affective neuroscience;Anhedonia;Anterior;arm;awake;Biological;Brain region;Chemicals;cingulate cortex;Clinic;Clinical;clinical research site;clinically significant;Cognition;Computer software;Conflict (Psychology);Decision Making;depressive symptoms;Disease;Dopamine;Elasticity;Electrochemistry;Electrodes;Electroencephalography;Emotional;Epilepsy;Foundations;Functional disorder;Functional Magnetic Resonance Imaging;Future;Goals;Hospitals;Human;Impairment;Implanted Electrodes;in vivo;Individual;Investigation;Learning;machine learning algorithm;Major Depressive Disorder;Measures;Medical;Mental Depression;Methods;Monitor;Moods;negative mood;neural;neurochemistry;neuroimaging;Neuromodulator;neurosurgery;Neurotransmitters;new technology;novel therapeutics;Participant;Pharmaceutical Preparations;Phase;Positron-Emission Tomography;Process;Public Health;Resistance;Resolution;response;Role;Serotonin;Signal Transduction;Specificity;symptomatic improvement;Symptoms;System;temporal measurement;Testing;Virginia

PROJECT_TITLE: Sub-second neurochemistry of error signals and affective processing in depression

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative  Myelodysplastic syndrome (MDS) is a frequently fatal type of blood disorder with few therapeutic options due to challenges in distinguishing and targeting the abnormal immature cells in the bone marrow. We have discovered that the levels of a specific receptor called CCRL2 are significantly higher in MDS cells compared to healthy cells and this molecule promotes the growth of these abnormal cells. We propose to determine the specific mechanisms of the growth activities of CCRL2 in MDS and develop therapies that will effectively suppress the growth of abnormal cells in MDS patients. .

PI_NAMEs: KARANTANOS, THEODOROS  (contact)

PROGRAM_OFFICER_NAME: DI FRONZO, NANCY L

PROJECT_TERMS: Abnormal Cell;Androgen Receptor;Azacitidine;Bone Marrow;burden of illness;C-terminal;career;career development;CCRL2 gene;Cell Cycle;cell growth;Cell surface;Cells;chemokine receptor;Computational Biology;CRISPR screen;CRISPR/Cas technology;Cytoplasm;Data;Development;Development Plans;Disease;DNA Repair;Drug Screening;Dysmyelopoietic Syndromes;Early Endosome;Endocytosis;Endosomes;Environment;Exhibits;experimental study;Gene Modified;Genes;Genomics;Growth;GTP-Binding Proteins;Hematological Disease;Hematopoiesis;Hematopoietic;high risk;Immunofluorescence Immunologic;improved;In Vitro;inhibitor;insight;Iron;JAK2 gene;knock-down;Knock-out;Lentivirus;Libraries;Light;Malignant - descriptor;Marrow;Mediating;men;Mentorship;Modeling;Molecular;Molecular Biology;Myelodysplastic/Myeloproliferative Disease;Myeloproliferative disease;new therapeutic target;novel;novel strategies;Oncogenic;Outcome;overexpression;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacology;Physicians;primitive cell;Property;Protein Binding Domain;Proteomics;Publishing;RB1 gene;receptor;Regulation;Research;research and development;Research Personnel;Resistance;Role;Sampling;Scientist;Sex Differences;Signal Pathway;Signal Transduction;skills;standard of care;Structure;Surface;targeted treatment;Technical Expertise;Testing;TFRC gene;Therapeutic;therapy development;Toxic effect;trafficking;Training;uptake;Woman;Work;Xenograft Model

PROJECT_TITLE: CCRL2 as a Regulator of Growth and Novel Target in Myelodysplastic Syndrome

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Genetic Testing;Genetics;Pancreatic Cancer;Patient Safety;Prevention;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Early diagnosis of pancreatic cancer (PDAC) remains challenging due to its asymptomatic nature, lack of early detection biomarkers, and limited availability of samples. This Clinical Validation Center (CVC) proposal aims to validate a previously optimized panel of biomarkers in blood and cyst fluid for risk stratification and early detection of PDAC in high-risk surveillance (pancreatic cystic lesions and subjects with a family history of malignancy due to germline mutation), and sporadic cohorts that are an increased risk for having an undiagnosed PDAC (patients with new-onset diabetes and chronic pancreatitis). A combination of retrospective and prospective studies will establish the clinical utility of biomarker panels for detecting interval malignancy in surveillance cohorts and early detection of sporadic malignancy.

PI_NAMEs: BATRA, SURINDER K.;BRAND, RANDALL  (contact)

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Accounting;Archives;Autoantibodies;Biological Markers;biomarker panel;biomarker performance;biomarker validation;Blinded;Blood;Blood specimen;Blood Vessels;blood-based biomarker;CA-19-9 Antigen;Cancer Etiology;candidate marker;candidate validation;case control;Case/Control Studies;Cessation of life;chronic pancreatitis;Clinical;cohort;Consensus;Cyst;Cyst Fluid;Cystic Lesion;Development;Diabetes Mellitus;Diagnosis;diagnostic biomarker;Disease;disease-causing mutation;Distant;draining lymph node;Dysplasia;early detection biomarkers;Early Diagnosis;Epitopes;Evaluation;Excision;Familial pancreatic cancer;Family;Family history of;Funding;General Population;Genetic;Germ-Line Mutation;Goals;Guidelines;high risk;high risk population;improved;Individual;inflammatory marker;Inherited;Laboratories;Lesion;Localized Disease;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;Medical center;Minority;Morbidity - disease rate;mortality risk;MUC5AC gene;Mucinous;Mucins;Mutation;Nature;Neoplasms;Newly Diagnosed;novel;Operative Surgical Procedures;Organ;Pancreas;Pancreatic Adenocarcinoma;Pancreatic Cyst;Pancreatic cystic neoplasia;Pancreatic Diseases;patient subsets;Patients;Performance;Persons;Phase;Population;Predisposition;prospective;Prospective Studies;Recording of previous events;Reporting;Resectable;Resected;Retrospective Studies;Risk;risk prediction;risk stratification;sample collection;Sampling;screening;Serum;Specificity;surveillance imaging;surveillance strategy;Survival Rate;TIMP2 gene;tumor;United States;Validation;validation studies

PROJECT_TITLE: Validation of biomarkers for risk prediction and early diagnosis of Pancreatic Adenocarcinoma


ADMINISTERING_IC: AI

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: SEATTLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The UW/Fred Hutch Center for AIDS Research (CFAR) is a multi-institutional consortium based in Seattle which catalyzes new HIV research and develops new research leaders across the multidisciplinary spectrum of basic, clinical, epidemiologic, statistical, sociobehavioral, and implementation science expertise necessary to bend the curve of the global HIV epidemic. During 35 years of continuous funding, the UW/Fred Hutch CFAR has facilitated substantial growth in research infrastructure, domestic and international partnerships, research impact, and development of emerging HIV researchers (with a return on investment on CFAR developmental awards of 1767%) with high added value and aided by significant institutional commitment. Through our proposed eight Cores and two Scientific Working Groups, we aim to expand multidisciplinary HIV research that spans bench to bedside to populations and grow new researchers, research leaders, infrastructure, and resources to impact the global epidemic.

PI_NAMEs: CELUM, CONNIE L (contact)

PROGRAM_OFFICER_NAME: SCHOONMAKER, ANNALISE ROSA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Advisory Committees;AIDS prevention;AIDS related cancer;anti-racism;Area;Award;base;Basic Science;Behavior Therapy;Behavioral;Behavioral Sciences;bench to bedside;Biological Markers;Cancer Center;cancer therapy;Cardiovascular system;care outcomes;career;CCR;Child;Chronic;Clinical;Clinical Research;Clinical Sciences;Collaborations;community engaged research;community engagement;community partnership;comorbidity;Complex;Data Analyses;Data Science;design;Development;Diagnosis;Disease;Educational workshop;Environment;Epidemic;Epidemiology;epidemiology study;Equity;equity, diversity, and inclusion;Fostering;Foundations;Funding;Goals;Growth;Hawaii;Health;health disparity;health equity;Hepatic;HIV;HIV Infections;Immunology;implementation facilitation;implementation science;improved;improved outcome;Incentives;Indigenous;Infection;Inflammation;Infrastructure;innovation;insight;Institution;interdisciplinary approach;Interdisciplinary Study;international partnership;Intervention;Investments;Leadership;Lung;marginalized population;member;Mentors;Metabolic;Methamphetamine;Methods;Minority;Mission;multidisciplinary;Neurologic;next generation;novel;Opioid;Outcome;Pathogenesis;Persons;Population;pre-exposure prophylaxis;prevent;Prevention;Prevention strategy;Process;programs;Qualitative Research;Reduce health disparities;Research;Research Design;Research Infrastructure;Research Institute;Research Personnel;Research Priority;Research Support;Resources;Retrovirology;Role;Science;Services;Social Behavior;Strategic Planning;substance use;success;symposium;Testing;Training;Translational Research;Translations;treatment strategy;United States National Institutes of Health;Universities;uptake;Vaccine Design;Washington;working group

PROJECT_TITLE: University of Washington/Fred Hutch Center for AIDS Research


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Advisory Committees;Award;Cancer Center;career;Collaborations;collaborative environment;combat;Communication;Communities;community engagement;community involvement;community organizations;Creativeness;Databases;Discipline;Ensure;Environment;Epidemic;equipment acquisition;Equity;equity, diversity, and inclusion;Fostering;Funding;Funding Opportunities;Future;global health;Goals;Grant;Growth;HIV;Human Resources;Income;innovation;Institution;International;Leadership;Link;Maintenance;medical schools;member;minority investigator;Mission;multidisciplinary;next generation;Policies;Prevention;Procedures;Productivity;programs;Progress Reports;recruit;Research;Research Personnel;Resources;response;Science;Service provision;Services;Source;Strategic Planning;Strategic vision;success;Surveys;synergism;System;Training;Trust;United States National Institutes of Health;Universities;Washington;Work

PROJECT_TITLE: A: Administrative


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Climate-Related Exposures and Conditions;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Public Health Relevance Statement/ Narrative The impact of air pollution and psychosocial stress on mental health outcomes remains poorly understood, particularly in the younger populations in which psychiatric symptoms often first arise. This proposal will explore the impact of air pollution and non-chemical stressors in relation to symptoms of anxiety and depression in preadolescents and the role of stress-related pathways in these relationships. Identification of modifiable risk factors during these earlier life stages could help prevent future mental and physical health burden later in life, resulting in an enormous benefit to individuals and society.

PI_NAMEs: MCGUINN, LAURA A (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: 11 year old;9 year old;Acute;Address;Adolescent;adolescent mental health;Adrenal Glands;Adult;age group;Air Pollution;Animal Experimentation;Anxiety;anxiety symptoms;Biological;Biological Markers;Biology;Biometry;Birth;Brain;career;Central Nervous System;Chemicals;Child;Child Mental Health;Childhood;Chronic;Cities;cohort;Cohort Studies;comorbidity;depressive symptoms;Development;developmental psychology;disability;Disease;Economics;Environment;Environmental Epidemiology;Environmental Risk Factor;environmental stressor;Epidemiology;epidemiology study;Etiology;Event;executive function;Exhibits;fine particles;Future;Genetic;Geography;Goals;Grant;Growth;Hair;Health;health data;High Prevalence;Hydrocortisone;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;Individual;Joints;Knowledge;Life;Life Cycle Stages;life span;Link;Measures;Mediating;Mediation;Mediator;Mental Depression;Mental disorders;Mental Health;Mentorship;Methods;Mexico;Modeling;modifiable risk;Morbidity - disease rate;Neighborhoods;Neurocognitive;Noise;Obesity;Outcome;Outcome Measure;Pathway interactions;Pediatrics;Persons;Phase;physical conditioning;Physiology;Pituitary Gland;Play;Population;Positioning Attribute;postnatal;preadolescence;Predisposition;Pregnancy;Prevalence;prevent;Production;programs;prospective;psychiatric symptom;Psychopathology;Psychosocial Stress;Public Health;public health relevance;remote sensing;Research;Research Activity;Resources;Risk Factors;Role;Rural;Salivary;sex;skills;social;social epidemiology;social stress;social stressor;Societies;statistics;Stress;stressor;Symptoms;Time;Toxic effect;Training;Training Activity;trend;urban area;urban setting;Violence;Work

PROJECT_TITLE: Effects of Urban Chemical and Non-Chemical Stressors on Preadolescent Mental Health

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


PI_NAMEs: JOHN-STEWART, GRACE C. (contact)

PROJECT_TERMS: Academy;Acquired Immunodeficiency Syndrome;Applications Grants;Award;Black, Indigenous, People of Color;career;career development;Collaborations;Communication;Communities;community engagement;community partnership;design;Development;Discipline;Educational workshop;Equity;equity, diversity, and inclusion;Evaluation;experience;Feedback;Fostering;Funding;Funding Opportunities;Goals;Grant;HIV;HIV/AIDS;improved;improved outcome;Infrastructure;innovation;Institution;International;Investments;Kenya;Leadership;life span;Lived experience;Manuscripts;member;Mentors;Mentorship;multidisciplinary;next generation;novel;Outcome;Persons;Peru;Process;Productivity;programs;Public Health;Research;Research Personnel;Research Priority;Research Support;Research Training;Resources;Risk;Scientist;skills;Strategic Planning;Structure;Study Section;success;symposium;Training;training opportunity;Uganda;United States National Institutes of Health;Universities;Washington;Work;working group;Writing

PROJECT_TITLE: B: Developmental


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: BROWN, ELIZABETH RENATA (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;analytical method;Applications Grants;Area;Behavioral;Behavioral Sciences;Bioinformatics;Biometry;Clinical;Clinical Research;Collaborations;Communities;Complex;Computer software;computing resources;Consultations;Data;Data Analyses;Data Analytics;Data Collection;data management;Data Science;Data Scientist;Database Management Systems;Databases;design;Development;Education;Educational workshop;Ensure;experience;Exposure to;Faculty;Funding;Goals;Grant;high school;HIV;implementation intervention;implementation science;improved;Infrastructure;innovation;Internships;Laboratory Study;Leadership;lectures;Link;Manuscripts;Mathematics;member;Mentors;Mentorship;Methodology;Methods;Mission;Modeling;multidisciplinary;next generation;novel;Outcome;personal narratives;Preparation;Publications;Publishing;Qualitative Methods;Qualitative Research;Randomized;Reporting;Reproducibility;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;research study;Research Support;Science;Scientist;secondary analysis;Services;Standardization;Statistical Data Interpretation;Statistical Methods;Students;symposium;theories;therapy development;Time;tool;tool development;Training;undergraduate student;Universities;uptake;Washington;Work

PROJECT_TITLE: C: Data Sciences and Methods


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: KITAHATA, MARI M (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;adjudication;Age;Aging;Alcohol consumption;American;antiretroviral therapy;Applications Grants;Automobile Driving;Basic Science;Behavioral;Behavioral Research;Biometry;Cardiovascular Diseases;career development;Cessation of life;Chronic;Chronic Disease;Clinic;Clinical;clinical care;Clinical Data;Clinical Medicine;cohort;Collaborations;Collection;Communities;community engagement;comorbidity;Consult;Consultations;COVID-19;Data;Data Science;Data Set;Data Sources;Databases;design;Development;Diabetes Mellitus;Discipline;Disease Management;Disease Progression;Drug usage;Education;Elderly;Eligibility Determination;eligible participant;Enrollment;Environment;Epidemiology;Equity;falls;Feasibility Studies;Fostering;frailty;functional decline;Grant;Health equity research;HIV;Hospitalization;immune activation;Impaired cognition;improved;improved outcome;Information Systems;Information Technology;innovation;innovative technologies;International;Leadership;life span;Liver diseases;Lung;Malignant Neoplasms;Manuscripts;Mentors;Mentorship;Metabolic;Methods;Morbidity - disease rate;mortality;multidisciplinary;multiple chronic conditions;Neurologic;next generation;North America;novel;Outcome;Participant;Patient Outcomes Assessments;Persons;Preparation;Prevention;Protocols documentation;Public Health Informatics;Publications;recruit;Research;Research Design;Research Personnel;Research Priority;Resources;Risk;Scientist;Services;Severities;Smoking;Social Behavior;social health determinants;socioeconomic disparity;Specimen;Statistical Data Interpretation;Statistical Methods;Stroke;substance use;success;symposium;Syndrome;System;Testing;tool;Training;Translational Research;Underrepresented Populations;Universities;Validation;Virus;Washington;Work;Writing

PROJECT_TITLE: Core G: Clinical and Comorbidity Research


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Prevention;Substance Misuse;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: HLADIK, FLORIAN  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Active Immunization;adaptive immune response;Administrator;AIDS prevention;Animals;antiviral immunity;Area;Award;Biological Assay;Biological Specimen Banks;Biology;Body System;career;Chronic;Clinical;Collaborations;community engagement;comorbidity;Consult;Consultations;Creativeness;Data;Data Analyses;data repository;Databases;Dedications;demographics;design;disease model;Disparity population;Drug Combinations;Educational workshop;Emerging Technologies;Ensure;Evaluation;Event;expectation;experience;experimental study;Face;Faculty;Formulation;Fostering;General Population;Goals;Grant;Group Meetings;Hearing;HIV;HIV Infections;HIV vaccine;HIV/AIDS;human tissue;Immune response;Immunity;Immunologics;Immunologist;Immunology;Individual;Inflammation;Innate Immune Response;Institution;instrument;Joints;Laboratories;latent HIV reservoir;Link;Measures;member;Mentorship;Metadata;Methods;minority investigator;Minority Participation;minority scientist;Modeling;Monitor;Mucous Membrane;new technology;news;operation;Outcome;Paper;Pathogenesis;Peer Review;Performance;Persons;Pharmaceutical Preparations;Phase;Prevention;Preventive vaccine;Process;programs;Proviruses;Publications;Publishing;reactivation from latency;Reporting;repository;Research;Research Personnel;Resources;Retrovirology;Sampling;Schedule;Science;Scientist;Services;Structure;success;Suggestion;Surveys;symposium;synergism;Techniques;Technology;Therapeutic Intervention;Thinking;Time;tissue culture;Tissue Model;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;vaccination strategy;Vaccine Design;Viral;virology;Virus;Washington;web site;Work;working group

PROJECT_TITLE: Core I: Immunology, Retrovirology and Cure


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE In the United States, tropical cyclones, such as hurricanes and tropical storms, have a devastating effect on society, yet a comprehensive assessment of their health impacts is still lacking. The proposed research is relevant to public health because it focuses on quantifying the hospitalization and mortality burden of tropical cyclones while also characterizing physical factors that drive differences in impacts on vulnerable communities. The results of this project are expected to greatly beneﬁt understanding of the health impacts of tropical cyclone exposure, and create actionable results that identify the most vulnerable communities, closely aligned with NIEHS's mission and Strategic Plan.

PI_NAMEs: PARKS, ROBBIE M (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: Acute;Algorithms;Area;Award;Bayesian Analysis;Bayesian Forecast;Bayesian Modeling;Big Data;career;Case Study;Cessation of life;Characteristics;Chronic;climate disaster;cohort;Collaborations;Communicable Diseases;Communities;community-level factor;Computer Vision Systems;cost;County;Data;Data Science;Data Sources;Death Rate;Demographic Factors;design;Disasters;Disease;Economic Factors;Environment;environmental disparity;Environmental Epidemiology;Environmental Hazards;Environmental Health;environmental health disparity;environmental justice;Epidemiologist;Epidemiology;experience;Exposure to;Failure;Goals;Growth;Hazard Models;Health;health assessment;health difference;health inequalities;Hospitalization;hospitalization rates;Housing;Human;Hurricane;Image;Imagery;improved;Inequity;Infrastructure;Injury;Institution;Knowledge;Machine Learning;Measures;Medicare;Medicare/Medicaid;Mental Health;Mentorship;Methodology;Mission;Modeling;Molds;mortality;Names;National Institute of Environmental Health Sciences;neglect;Neighborhoods;neural network;novel;Outcome;Phase;Policies;programs;Public Health;Reporting;Research;Respiratory Disease;Seasons;skills;social disparities;social epidemiology;social factors;Societies;spatiotemporal;Strategic Planning;Stress;Techniques;Training;training data;trend;United States;United States National Center for Health Statistics;Variant;vulnerable community

PROJECT_TITLE: Novel Assessments of the Health Impacts of Tropical Cyclones


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Rare Diseases;Substance Misuse

PI_NAMEs: MENON, MANOJ P (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Africa;Africa South of the Sahara;AIDS related cancer;analytical tool;antiretroviral therapy;Award;biobank;Biocompatible Materials;Biological Assay;Biological Markers;Biological Specimen Banks;Cancer Biology;cancer biomarkers;cancer risk;cancer therapy;Cardiovascular Diseases;career;Cause of Death;Cessation of life;Chronic;clinical investigation;Clinical Research;Collaborations;Communities;Consultations;Data;Data Element;design;Development;diagnostic assay;Disease;Educational workshop;Environmental Risk Factor;epidemiology study;Faculty;Fostering;Genetic;genetic analysis;Goals;Grant;Histopathology;HIV;HIV Infections;Image;Image Analysis;image archival system;imaging study;Incidence;Infection;Inflammation;innovation;insight;instrument;International;Intervention;Kaposi Sarcoma;Kenya;Laboratories;Life Expectancy;Longitudinal cohort;Lung;Lung Diseases;Lymphoma;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Medical;member;Mentors;Mentorship;Methodology;Methods;Molecular;Molecular Analysis;Molecular Diagnostic Testing;multidimensional data;Non-Hodgkin's Lymphoma;novel;Oncogenic Viruses;optimal treatments;Participant;Pathogenesis;Persons;preservation;prevent;Prevention;prospective;Protocols documentation;Pulmonology;radiological imaging;repository;Research;Research Personnel;Resources;Risk;Role;Sampling;Series;Services;skills;Specimen;success;Tissues;tool;Translational Research;translational study;tumor;Tumor Tissue;Uganda;Ultrasonography;Universities;Washington

PROJECT_TITLE: Core K: Biomarkers, Prevention and Interventions for HIV-associated Malignancies and NCDs


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse;Telehealth

PI_NAMEs: RAO, DEEPA  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Adopted;AIDS prevention;Alcohol consumption;antiretroviral therapy;Archives;Area;Attention;Award;Behavior;behavior measurement;Behavioral;behavioral outcome;Behavioral Research;Behavioral Sciences;Caring;Climate;Collaborations;combat;Communicable Diseases;Communication;Communities;community engaged approach;community engagement;community organizations;community partners;Consultations;Data;Development;Diagnosis;digital;digital data;digital health;digital technology;digital tool;Disabled Persons;Education;Educational workshop;eHealth;electronic data;Electronic Mail;Epidemic;Epidemiologist;Equity;Ethics;Ethnic Origin;Ethnic Population;Faculty;Financial Support;Funding;Goals;Grant;Health;health care availability;health care disparity;health equity;Health Services;HIV;HIV Infections;improved;Indigenous;Individual;innovation;Institution;instrument;interest;International;Intervention;Intervention Studies;Journals;Knowledge;Lead;Learning;Manuscripts;Measurement;meetings;member;Mental Depression;Mentors;Mentorship;Methods;Modeling;multidisciplinary;multilevel analysis;mutual learning;Nature;online intervention;Participant;people of color;Persons;Physicians;Policies;Populations at Risk;pre-exposure prophylaxis;Prevention;Psychologist;Publications;Publishing;Race;racial population;Reporting;Research;Research Personnel;Research Priority;Resources;scale up;skills;Social Justice;social media;Social Network;Structural Models;substance use;success;symposium;synergism;technological innovation;Technology;telehealth;theories;Time;Training;Travel;United States National Institutes of Health;Universities;uptake;Validation;Voice;Washington;Work

PROJECT_TITLE: Core L: Behavioral Innovations


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: SHERR, KENNETH  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;AIDS prevention;Applications Grants;Applied Research;Area;base;career;Caring;cohort;Collaborations;Communities;community research;Consultations;County;Data;Decision Making;design;Development;economic evaluation;Educational Curriculum;efficacious intervention;Epidemic;Equity;Evaluation;Evidence based intervention;experience;Extramural Activities;Faculty;Fostering;Funding;Future;global health;Grant;Growth;Health;Health Sciences;HIV;HIV/AIDS;Human Resources;implementation research;implementation science;improved;Infection;innovation;International;Intervention;Investments;Knowledge;Lead;Link;member;Mentorship;Methodology;Methods;Morbidity - disease rate;mortality;multidisciplinary;novel;Pacific Northwest;Participant;peer;Population;prevent;Prevention;Program Effectiveness;Program Evaluation;programs;Public Health;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;Research Proposals;residence;Resource Development;scale up;Scientific Advances and Accomplishments;Series;skills;Speed;Structure;success;symposium;Training;training opportunity;Training Support;Translating;United States National Institutes of Health;Universities;uptake;Washington;working group

PROJECT_TITLE: Core M: Implementation Science


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

PI_NAMEs: ORELLANA, EDWIN ROBERTO  (contact)

PROJECT_TERMS: Achievement;Acquired Immunodeficiency Syndrome;Address;Affect;AIDS prevention;Area;Attention;Black, Indigenous, People of Color;career;Caring;Characteristics;Collaborations;Communities;community engagement;community partners;community partnership;community-centered;Complex;County;COVID-19 pandemic;Data;design;Development;Discrimination;Disparity;disparity elimination;Disparity population;Epidemic;Equity;equity, diversity, and inclusion;Fostering;Funding;Funding Mechanisms;Funding Opportunities;Generations;Goals;Group Meetings;Growth;health care disparity;health determinants;health difference;health disparity;health disparity populations;health equity;Health equity research;health inequalities;HIV;HIV disparities;Individual;Inequity;innovation;Institution;interdisciplinary collaboration;Interdisciplinary Study;interest;International;Intervention;Leadership;Lesbian Gay Bisexual Transgender Queer;Manuscripts;marginalization;marginalized population;meetings;member;Modeling;multidisciplinary;Nature;Outcome;Pacific Northwest;Peer Review;Persons;Population;Poverty;Prevention;Prevention Research;programs;Public Health;Public Health Practice;Publications;racism;Research;research in practice;Research Personnel;Research Project Grants;Research Proposals;Resources;Services;Shapes;social determinants;Societies;Source;structural health determinants;Testing;transmission process;treatment research;United States National Institutes of Health;Universities;Washington;Work;working group

PROJECT_TITLE: SWG 10: Health Equity


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: TSUI, JUDITH  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;addiction;Address;Adherence;Affect;AIDS prevention;Alcohols;Applications Grants;Area;Behavioral;Black race;Cannabis;Caring;Collaborations;Communities;community engagement;Continuity of Patient Care;County;Data;Dedications;Disease;Disease Outbreaks;disease transmission;Disparity;Educational workshop;Electronic Mail;Epidemic;Faculty;Feedback;Fostering;Funding;Goals;Grant;Health;HIV;improved;Indigenous;Injecting drug user;innovation;interdisciplinary collaboration;Interdisciplinary Study;interest;Intervention;Knowledge;Lived experience;Manuscripts;meetings;Mental disorders;Mentorship;methamphetamine use;multidisciplinary;National Institute of Drug Abuse;Newsletter;Nicotine;novel;Opioid;opioid epidemic;Participant;patient oriented;Pattern;peer;people of color;Persons;Pharmaceutical Preparations;polysubstance use;Population;Positioning Attribute;prevent;Public Health;Publications;Publishing;Research;Research Personnel;Research Support;Risk;sedative;Sexual and Gender Minorities;skill acquisition;skills;social;Stimulant;Students;substance use;Substance Use Disorder;success;Testing;Training Programs;treatment as prevention;United States;United States National Institutes of Health;Universities;Unsafe Sex;Vulnerable Populations;Washington;Work;working group

PROJECT_TITLE: SWG 11: Substance Use


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Substance Misuse

ORG_CITY: WASHINGTON

ORG_NAME: AMERICAN PSYCHIATRIC ASSOC FOUNDATION

ORG_STATE: DC

PHR: Project Narrative/Public Health Impact The Research Colloquium for Junior Psychiatrist Investigators (Research Colloquium) is an innovative multi-component research training, mentoring and career development program that involves interactive pre- and post-colloquium webinars, a 2-day, immersive, mentoring and networking event, a 6-month booster session at the American College of Neuropsychopharmacology Annual Meeting, a 12-month booster session at the Society of Biological Psychiatry, and yearlong networking and mentoring through an online Research Colloquium community. The program helps address the documented lack of psychiatric researchers, especially among women and ethnic minorities, in this country, by providing research experience for early career psychiatrists, including senior residents, research fellows and junior faculty across age, ethnoracial, gender identity and sexual orientation groups, who meet with distinguished senior research mentors to receive advice on their planned research studies. The overarching goal is to encourage early career psychiatrist investigators, especially minoritized populations and women, to develop and maintain a research career path and includes pre- and post-colloquium activities such as webinars, interactive online Q&A sessions, and discussion boards to ensure longer-term mentoring and career guidance to the junior investigators.

PI_NAMEs: CLARKE, DIANA ELAINE (contact)

PROGRAM_OFFICER_NAME: COLLIER KIDEMU, KEVA WONTORIA

PROJECT_TERMS: Academia;academic program;Address;Age;Alcohols;American;American Psychiatric Association;Appointment;Area;Award;Biological Psychiatry;Brain;career;Career Choice;career development;Clinical;cohort;Collaborations;college;Communities;cost;Country;early experience;Educational Curriculum;Ensure;ethnic minority;ethnoracial;Event;experience;Faculty;faculty mentor;Feedback;Fellowship;follow-up;Funding;Future;Gender Identity;Geriatric Psychiatry;Goals;Grant;Health Disparities Research;health disparity;Health Services;improved;Incentives;Industry;innovation;Institute of Medicine (U.S.);Institution;interest;Interruption;Intervention Studies;Journals;Measures;Medicine;meetings;Mental Health;Mentors;Mentorship;Methodology;Military Personnel;Minority Groups;Minority Women;neuropsychopharmacology;Neurosciences;Neurosciences Research;online community;Pain;Participant;peer;Peer Review;Persons;Physicians;Positioning Attribute;Post-Traumatic Stress Disorders;posters;Privatization;Program Development;programs;Protocols documentation;Psychiatrist;Psychiatry;psychobiology;Public Health;Publications;Recommendation;Research;Research Infrastructure;Research Personnel;Research Project Grants;research study;Research Training;Residencies;Resources;Role;Science;Scientist;Sex Orientation;skills;Societies;Solid;statistics;substance use;success;Suicide;symposium;Training;Translational Research;treatment research;Update;Veterans;Vocational Guidance;webinar;Woman;working group

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 GXM-T (O1)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative The histidine kinases and histidine phosphatases are a poorly understood family of enzymes that play critical roles in G-protein signaling, ion conduction, central metabolism and chromatin biology and have been implicated in diseases as diverse as cardiovascular disease and cancer. The main barrier to a better understanding of these enzymes is a lack of tools available to study them. Research in the Barrios lab is focused on developing the tools necessary to study the enzymes involved in histidine phosphorylation and dephosphorylation, including cell-compatible fluorogenic substrates and targeted inhibitors. In addition, we are investigating the context cues that facilitate histidine phosphorylation and the impact of histidine phosphorylation on protein structure and function.

PI_NAMEs: BARRIOS, AMY M (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Biological;Biological Assay;Biology;Cardiovascular Diseases;Cells;Chemicals;Chromatin;Cues;Disease;Enzymes;Family;Fluorogenic Substrate;Goals;GTP-Binding Proteins;Health;Histidine;inhibitor;insight;Ions;Laboratories;Lead;Malignant Neoplasms;Mammals;Metabolism;Metal Ion Binding;Monitor;Pathway interactions;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Play;Protein Dephosphorylation;protein function;protein structure;protein-histidine kinase;Proteins;Research;Role;Signal Pathway;Signal Transduction;Signaling Protein;therapeutic target;tool;Work

PROJECT_TITLE: Out of the shadows: Illuminating mammalian histidine phosphorylation

STUDY_SECTION: MRAE

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - E Study Section[MRAE]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autoimmune Disease;Chronic Pain;Complementary and Integrative Health;Diabetes;Neurodegenerative;Neurosciences;Nutrition;Pain Research;Peripheral Neuropathy;Prevention

ORG_CITY: KANSAS CITY

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative  Peripheral axon loss, poor sensation and pain are all components associated with diabetic peripheral neuropathy and new treatment approaches to correct these complications are desperately needed. We will determine if ketones bodies have direct actions on sensory neurons to improve their metabolism, stimulate axon growth, improve sensation and reduce pain.

PI_NAMEs: WRIGHT, DOUGLAS E (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Acetoacetates;Affect;Afferent Neurons;allodynia;Analgesics;antinociception;Attenuated;Axon;axon growth;axon guidance;axon regeneration;axonal degeneration;beta-Hydroxybutyrate;Cells;chemotherapy induced neuropathy;clinical pain;Clinical Research;Clinical Treatment;Consumption;Cutaneous;design;Diabetes Mellitus;diabetic;Diabetic mouse;Diabetic Neuropathies;diabetic patient;Diet;Dietary Intervention;Distal;Electrophysiology (science);Enzymes;Esthesia;Exercise;experimental study;Fiber;Future;Gait abnormality;Glucose;improved;In Vitro;in vivo;inhibitor;Injections;interdisciplinary approach;interest;Intervention;ketogenic diet;Ketone Bodies;Ketones;Limb structure;Liver;Measures;mechanical allodynia;Mediator;Metabolic;Metabolism;Mitochondria;Modeling;mouse model;Mus;nerve supply;Neurites;Neurodegenerative Disorders;neuronal metabolism;Neurons;neurotrophic factor;novel therapeutic intervention;Numbness;Pain;pain behavior;Pain management;pain reduction;pain relief;Pathway interactions;Patients;Peripheral;Peripheral Nerves;Peripheral Nervous System Diseases;Play;Prediabetes syndrome;prevent;Property;Pyruvaldehyde;Quality of life;Research;response;Risk;Sensory;Signal Pathway;Signal Transduction;Source;Spinal;Spinal Ganglia;Streptozocin;Supplementation;symptomatic improvement;Symptoms;Testing;therapeutic target;Toxic effect;Work

PROJECT_TITLE: Painful Versus Insensate Diabetic Neuropathy

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Tobacco remains the leading preventable cause of death in the U.S. and is also the leading preventable cause of death among people with substance use disorders. This innovative training program has a primary focus on tobacco with emerging areas of focus on cannabis and tobacco co-use and industry research that extends from tobacco to pharmaceutical opioids. We will prepare the next generation of leaders in substance use and addiction science with a combination of coursework and mentored research in a collaborative environment that has a proven record of integrating multiple disciplines to translate science to improve public health policy and clinical practice.

PI_NAMEs: APOLLONIO, DOROTHY ELINOR;LING, PAMELA MAY (contact);VIJAYARAGHAVAN, MAYA

PROGRAM_OFFICER_NAME: KAUTZ, MARY A

PROJECT_TERMS: post-doctoral training;tobacco control

PROJECT_TITLE: Postdoctoral training in tobacco control


ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: NARRATIVE The goal of our work is to understand how mammalian cells integrate receptor signals and cell contacts to make decisions whether to move and proliferate. These decisions are critical both for cancer and tissue regeneration and understanding how cells make these decisions will predict synergistic signaling activities that can be targeted to treat cancer and restore tissue function.

PI_NAMEs: MEYER, TOBIAS  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Actins;Animals;Biochemical;Cancer Etiology;Cell Death;Cell Differentiation process;Cell membrane;Cell Nucleus;Cells;Complex;Cultured Cells;Cyclins;Decision Making;Disease;DNA biosynthesis;Feedback;genetic approach;Genomic Instability;Goals;Hour;Laboratories;Licensing;Maintenance;Malignant Neoplasms;Mammalian Cell;Methods;Microscopy;migration;Molecular;Movement;Mutation;Outcome;pathogen;Phosphotransferases;prevent;Process;Proliferating;receptor;Receptor Cell;Receptor Protein-Tyrosine Kinases;Receptor Signaling;Replication Origin;Reporter;Signal Transduction;single cell analysis;stem cell differentiation;tissue regeneration;Tissues;tool;Work

PROJECT_TITLE: Cell Signaling and Cell Decisions

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Cardiovascular;Hypertension

ORG_CITY: MEMPHIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: Project Narrative Endothelial cells regulate arterial contractility. Dysfunctional endothelial cell control of contractility is a hallmark of several cardiovascular diseases, including hypertension, but pathological mechanisms involved are poorly understood. We will investigate the novel hypothesis that rapid trafficking of small-conductance calcium-activated channels regulates arterial contractility, investigate signaling mechanisms involved and test the concept that vasodilation mediated through these pathways is dysfunctional during hypertension.

PI_NAMEs: JAGGAR, JONATHAN H (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Arteries;Attenuated;Biotinylation;Blood;Blood Pressure;Blood Vessels;Calcium;Calcium Signaling;Cardiovascular Diseases;Cell Line;Cell membrane;Cells;Data;Electrophysiology (science);Endothelial Cells;familial hypertension;Fluorescence Resonance Energy Transfer;fluvastatin;Functional disorder;Genes;Genetic;Human;Hypertension;hypertensive;Image;Immunofluorescence Immunologic;inhibitor;Ion Channel;Knockout Mice;Mediating;Membrane Potentials;Membrane Proteins;Methods;Modeling;mouse model;Mus;mutant;Mutation;Myography;novel;patch clamp;Pathologic;Pathway interactions;Patients;Physiological;Potassium;Probability;Process;Proteins;rab GTP-Binding Proteins;receptor;RNA Interference;Signal Transduction;stem;Stimulus;superresolution microscopy;Surface;Systemic blood pressure;Systemic hypertension;Telemetry;Testing;trafficking;Transgenic Mice;TRP channel;Urine;Vanilloid;vasoconstriction;Vasodilation;Vasodilator Agents;Western Blotting

PROJECT_TITLE: SK3 channel trafficking in endothelial cells

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: CINCINNATI

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Our understanding of the voice production mechanisms can be enhanced by investigating the fluid dynamics that occur in the glottis. We propose to develop a novel measurement technique that will capture the intraglottal airflow volume distribution.

PI_NAMEs: FARBOS DE LUZAN, CHARLES  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TITLE: Three dimensionality of the intraglottal flow

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: HOUSTON

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will provide a novel approach to mitigating aldehyde overload, a common pathological condition that currently has no clinical treatments. Small molecule intracellular metal catalysts (SIMCats) could offer therapeutic advantages over conventional aldehyde traps due to their distinct catalytic detoxification mechanism. This work will help streamline the SIMCat discovery process and increase the likelihood of success in translating catalytic chemistry from the reaction flask to living systems.

PI_NAMEs: DO, LOI HUNG (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Alcohols;Aldehydes;Alkenes;Antioxidants;Atherosclerosis;Behavior;Biochemical;Biological;Biological Markers;Biological Sciences;biological systems;biomaterial compatibility;Brain;Carbamates;Carnosine;Catalysis;catalyst;cell injury;Cells;chemical stability;Chemicals;Chemistry;Clinical Treatment;Complex;Consumption;Copper;Coupling;Cytoprotection;cytotoxic;Development;Disease;Drug Metabolic Detoxication;Electrons;Enzymes;Event;experimental study;FDA approved;flasks;fluorescence imaging;Glutathione;Goals;Health;Human;human disease;Hydrogenation;Hydrolysis;Imaging Techniques;improved;in vivo;Individual;innovation;insight;interest;Kinetics;Life;Malignant Neoplasms;Mammalian Cell;Measures;metal complex;Metals;Methodology;Methods;Monitor;Nature;neuroblastoma cell;Neurodegenerative Disorders;novel;novel strategies;Organism;Outcome;Oxidation-Reduction;Oxidative Stress;Pathologic;Phloretin;Process;programs;Public Health;ratiometric;Reaction;reaction rate;Reactive Oxygen Species;remediation;Research;Scientist;single molecule;small molecule;Structure-Activity Relationship;success;superresolution microscopy;synthetic enzyme;System;Techniques;Technology;Testing;Therapeutic;Thermodynamics;Tissues;Toxic effect;toxicant;Translating;Translations;Visualization;Work;Zebrafish

PROJECT_TITLE: Development of Transfer Hydrogenation Small-Molecule Intracellular Metal Catalysts (SIMCats) and their Application Toward Toxic Aldehyde Remediation

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: TUCSON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: The proposed research is relevant to human health because the studies focus on determining the contributions of a fundamental biologic process—metabolic signaling—to the pathogenesis of a common human pathogen— human cytomegalovirus. This project will investigate an understudied role of metabolite signaling in viral infections.

PI_NAMEs: PURDY, JOHN GERARD (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Anti-viral Agents;Anti-viral Response;Area;Aryl Hydrocarbon Receptor;Attention;Attenuated;attenuation;Binding;Biological Assay;Biological Process;Biology;Cause of Death;Cells;chronic infection;Clinical;congenital infection;CRISPR/Cas technology;Cytomegalovirus;Cytomegalovirus Infections;Data;disability;Disease;Engineering;Enzymes;extracellular;Goals;Health;HIF1A gene;Human;human pathogen;Hypoxia Inducible Factor;Immune Evasion;Immune response;Immune system;Infection;Knowledge;Kynurenine;Mediating;Mediator;Metabolic;Metabolism;metabolomics;Modeling;Molecular;novel;novel strategies;novel therapeutic intervention;Organ;Pathogenesis;Pathway interactions;Pregnancy;prevent;Process;Production;Proteins;Proviruses;receptor internalization;Research;response;Role;Signal Pathway;Signal Transduction;Solid;Stem cell transplant;Transplant Recipients;Tryptophan Metabolism Pathway;Vaccines;Viral;Viral Proteins;Virus;Virus Diseases;virus host interaction;Virus Integration;Virus Replication;Work

PROJECT_TITLE: Metabolite-mediated Signaling in Cell-to-Cell Spread of Human Cytomegalovirus

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Neurosciences;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE Evidence-based treatments for Alcohol Use Disorder (AUD) in young adults are lacking, and the neural mechanisms associated with effective treatments are poorly understood. The proposed study will develop and test an integrated AUD randomized controlled trial intervention, among young adults, to improve treatment efficacy and inform about the neural mechanisms of treatment. Further, findings will help advance the development of future interventions to improve alcohol abstinence and ultimately reduce the number of young adults who develop AUD.

PI_NAMEs: HALLIHAN, HAGAR  (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: acceptability and feasibility;Advanced Development;Affect;African American;African American Women;Aftercare;Age;age group;aged;alcohol abstinence;alcohol abuse therapy;Alcohol consumption;Alcohol dependence;alcohol screening;alcohol use disorder;Alcohols;Amygdaloid structure;arm;Award;Behavior Therapy;behavioral clinical trial;behavioral study;Benchmarking;brain dysfunction;Brain region;Brief Psychotherapy;Chronic Disease;Client satisfaction;Clinical Research;clinically relevant;cognitive control;Collaborations;Competence;contingency management;cost;Data;Data Analyses;Data Collection;design;Disease;effective therapy;effectiveness evaluation;efficacy evaluation;efficacy testing;Enrollment;Ensure;Environment;Evaluation;Evidence based treatment;experience;feasibility testing;Female;Focus Groups;follow-up;Functional Magnetic Resonance Imaging;functional MRI scan;Future;Goals;Health;high risk drinking;Impairment;improved;Individual;innovation;Institution;Intervention;Intervention Trial;Interview;Knowledge;Leadership;Life;male;Mediating;meetings;Mentors;Mentorship;motivational enhancement therapy;National Institute on Alcohol Abuse and Alcoholism;negative affect;neural;neural circuit;Neurobiology;neuroimaging;neuromechanism;Neurosciences;older adult;Outcome;Participant;patient population;Persons;Phase;pilot trial;Positioning Attribute;Prefrontal Cortex;Prevention;primary outcome;problem solving therapy;programs;Protocols documentation;Public Health;Qualitative Research;Questionnaires;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;reduced alcohol use;remote delivery;Research;Research Methodology;Research Personnel;Research Training;reward circuitry;Rewards;satisfaction;Science;Senior Scientist;skills;Smoking;Structure;Symptoms;System;Target Populations;Testing;Therapeutic Intervention;therapy design;therapy development;Training;treatment effect;Treatment Efficacy;Urine;Ventral Striatum;videoconference;young adult

PROJECT_TITLE: StuDy AimED at Increasing AlCohol AbsTinEnce (DEDICATE)

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Prevention;Women's Health Research

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: Project Narrative In this proposal, use of radiological clips that can also serve as a calibration target for spectral-based quantitative ultrasound will be assessed for their ability to account for transmission and attenuation losses and thereby improving the accuracy of quantitative ultrasound to identify the early response of breast cancer patients to chemotherapy. Radiological clips are already an integral part of treatment course for patients undergoing neoadjuvant chemotherapy in breast cancer. We will evaluate multiple clip materials and physical sizes through phantom studies, studies in animal models of breast cancer and validate the process in a human study of locally advanced breast cancer patients undergoing neoadjuvant chemotherapy.

PI_NAMEs: OELZE, MICHAEL L. (contact)

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: Accounting;Adjuvant Chemotherapy;Adoption;advanced breast cancer;Anatomy;Animal Cancer Model;Animal Model;Animals;attenuation;Breast;Breast Cancer Model;Breast Cancer Patient;Breast Cancer therapy;Calibration;Cancer Detection;Cell Death;chemotherapy;Classification;Clinic;Clinical;clinical imaging;Clinical Research;Clip;Cosmetics;Data;Diagnosis;Diagnostic;Early identification;electric impedance;Female;Gold;hormone therapy;Human;human study;Imaging Techniques;improved;In complete remission;In Situ;in vivo;Longitudinal Studies;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Mammography;man;Medical;Monitor;Neoadjuvant Therapy;North America;novel;Operative Surgical Procedures;Outcome;Pathologic;Patients;Physical assessment;predicting response;Procedures;Process;Property;quantitative ultrasound;Radiation therapy;Radiology Specialty;Recurrence;Research;Residual Cancers;responders and non-responders;response;Roentgen Rays;Shapes;Signal Transduction;standard care;Surgeon;Techniques;technology validation;Testing;Time;Tissues;Titanium;tool;Translating;transmission process;treatment response;tumor;Ultrasonics;Ultrasonography;ultrasound;Woman

PROJECT_TITLE: Use of Radiological Clips for Improving Quantitative Ultrasound Imaging

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: DALLAS

ORG_DEPT: PEDIATRICS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE The treatment for glioma, the most common type of brain tumor, has not changed in over 20 years. Our laboratory has identified that drugs targeting a specific metabolic pathway preferentially kill brain tumor cells with a mutation in the gene IDH1, a very common alteration in this incurable disease. This proposal will study why these tumor cells become dependent on this specific metabolic pathway, potentially assisting in the development of targeted therapies to alleviate the burden of this deadly cancer.

PI_NAMEs: SAVANI, MILAN RASHMIN (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Affect;Astrocytes;Biochemical Pathway;Biology;Brain;Brain Neoplasms;cancer cell;career;Cell Line;Cell Survival;Cells;Clinic;Clinical Trials;Complex;Dependence;Development;DHODH gene;Dihydroorotate dehydrogenase;Disease;driver mutation;Drug Screening;Drug Targeting;enzyme biosynthesis;Enzyme Interaction;Enzymes;Equilibrium;experimental study;Fellowship;Genes;Glioma;Glutamine;Human;Immunofluorescence Microscopy;Immunoprecipitation;in vivo;inhibitor;inhibitor therapy;Isocitrate Dehydrogenase;Laboratories;Link;liquid chromatography mass spectrometry;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Metabolic;Metabolic Pathway;Metabolism;Modeling;Molecular;Multienzyme Complexes;mutant;Mutation;neoplastic cell;nerve stem cell;new therapeutic target;Nitrogen;nitrogen metabolism;Normal Cell;novel;novel therapeutics;nucleotide metabolism;Oncogenes;Oncoproteins;Pathway interactions;Patient Selection;Patients;Pediatric Oncologist;Pharmaceutical Preparations;Phenotype;Physiological;Pre-Clinical Model;Production;Pyrimidine;Pyrimidine Nucleotides;Pyrimidines;Regulation;Repression;Research;research clinical testing;Resistance;response;response biomarker;Role;Route;Scientist;stable isotope;Starvation;stem-like cell;targeted treatment;Testing;Therapeutic;Training;treatment strategy;tumor;Uridine;Uridine Monophosphate;Western Blotting;Work;Xenograft Model

PROJECT_TITLE: Dissecting Mechanisms of Pyrimidine Synthesis Dependence in IDH Mutant Glioma


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Aberrant expression of PDE2A was found in the brain of AD patients and animal models accompanied by impaired cAMP/cGMP signaling and in vitro studies suggested a critical role of aberrant PDE2A signaling in mediating Aβ-induced mitochondrial dysfunction and neuronal dysfunction. In this application, we proposed to investigate the causal involvement of aberrant PDE2A2 signaling in mitochondrial/neuronal dysfunction and the pathogenesis of AD in vivo and explore the underlying mechanism which will likely pave the way for developing treatment targeting mitochondrial dysfunction in AD.

PI_NAMEs: XU, YING  (contact);ZHU, XIONGWEI

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: AD transgenic mice;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Amyloid beta-Protein;Animal Model;APP-PS1;Behavior;Behavioral;Brain;Brain region;Cell Physiology;Cell Respiration;Cognition;Cognitive;Cognitive deficits;cognitive enhancement;cognitive function;Complex;conditional knockout;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cyclic GMP;Cytosol;Data;Defect;drug development;Electron Transport;Enzymes;Exclusion;Future;Hippocampus;Hydrolysis;Impairment;In Vitro;in vivo;inhibitor;insight;Knock-out;Knockout Mice;Link;Literature;Mediating;Mitochondria;mitochondrial dysfunction;Mitochondrial Matrix;Modeling;Molecular;mouse model;Mus;Nerve Degeneration;Neuronal Dysfunction;Neurons;novel;overexpression;Pathogenesis;Pathologic;PDE2 phosphodiesterase;phosphoric diester hydrolase;Play;Predisposition;Prosencephalon;Protein Isoforms;Regulation;Respiration;respiratory;Role;Second Messenger Systems;Signal Transduction;Synapses;synaptic function;Temporal Lobe;Testing;therapeutic target

PROJECT_TITLE: Role of PDE2A in mitochondrial dysfunction in Alzheimer’s disease

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD-R]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative This study proposes to use friendship data from a cohort of high school students in Southern California from an NIH-funded R01 to determine the social influence effects of perceived friend norms and friend e-cigarette use on individual e-cigarette use. The project will also evaluate the longitudinal relationship between friend influence and e-cigarette initiation and use a simulation model to determine how potential behavioral interventions would affect e-cigarette use outcomes in the network. The results of these analyses can be used to create a framework for a network-based intervention to change normative perceptions and ultimately decrease e-cigarette use among adolescents.

PI_NAMEs: PIOMBO, SARAH ELIZABETH (contact)

PROGRAM_OFFICER_NAME: CREAMER, MELISA RAY

PROJECT_TERMS: Address;Adolescent;Adolescent and Young Adult;Adolescent Behavior;Affect;Attitude;Automobile Driving;Behavior;behavior influence;Behavior Therapy;Behavioral;Belief;California;cigarette smoking;cohort;combustible cigarette;combustible tobacco;Complex;Data;demographics;e-cigarette cessation;Electronic cigarette;electronic cigarette use;Electronic Nicotine Delivery Systems;Exposure to;Friends;Friendships;Funding;Future;Health;Health behavior;Health behavior change;high school;High School Student;Individual;Influentials;innovation;insight;Intervention;Literature;Measures;Methodology;Middle School Student;Modeling;models and simulation;Nature;Network-based;ninth grade;novel;Outcome;Participant;Pathway Analysis;Pathway interactions;Patient Self-Report;Pattern;peer;peer influence;peer networks;Perception;Persons;prevent;recruit;Reporting;Research;Rest;Risk Behaviors;Risk Estimate;Schools;self reported behavior;Shapes;social;social influence;Social Network;Social Sciences;Students;substance use;Surgeon;Surveys;Thinking;Time;Tobacco;tobacco control;Tobacco use;United States National Institutes of Health;vaping;Youth

PROJECT_TITLE: Normative and Network Influences on ENDS use (Electronic nicotine delivery systems- e-cigarettes/vaping)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: A key to improving racial, ethnic, and socioeconomic inequities in preterm infant health outcomes is for the family to be engaged with the preterm infant during the hospitalization in the neonatal intensive care unit. However, there are many disproportionate barriers faced by marginalized families in order to visit with their infant. This research aims to understand these barriers in mixed methods study and evaluate the effects of the most salient of these, paid family leave, in order intervene to ensure families can engage in their preterm infant's care, and ultimately, improve preterm health outcomes.

PI_NAMEs: QUINN, MARY  (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Address;Advisory Committees;Affect;Automobile Driving;barrier to care;Black race;Breast Feeding;Breastfed infant;California;career;Caring;Child;Child Care;cohort;Data;design;Development;disadvantaged background;Disparity;Ensure;Epidemiologist;Ethnic Origin;evidence base;Exclusion;experience;extreme prematurity;Face;falls;Family;Family Leave;feeding;Foundations;Future;Goals;Health;health inequalities;Health Services Research;Hospitalization;Hospitals;Human Milk;improved;Income;Inequity;Infant;Infant Care;Infant Development;Infant Health;infant outcome;informant;Interruption;Intervention;Interview;Language;Latinx;Length of Stay;lower income families;marginalization;marginalized population;Mental Health;Methods;Modeling;Modification;Native Americans;Neonatal;neonatal health;Neonatal Intensive Care Units;neonatal outcome;Observational Study;Occupations;Outcome;Parents;Pattern;Perinatal;perinatal health;Policies;Population;Premature Infant;Prevalence;prevent;programs;Qualitative Research;Race;racial disparity;Reduce health disparities;Reporting;Research;Research Personnel;Research Project Grants;Risk;Role;Series;Skin;Skin Care;social;socioeconomic disadvantage;socioeconomic disparity;sociologist;Structure;Subgroup;success;Surveys;theories;therapy design;Time;Training;Transportation;transportation access;trend;Visit

PROJECT_TITLE: Inequities in family engagement in the neonatal intensive care unit


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Rheumatoid Arthritis

ORG_CITY: New York

ORG_NAME: HOSPITAL FOR SPECIAL SURGERY

PHR: PROJECT NARRATIVE Rheumatoid arthritis (RA) afflicts over 1 million American adults, causing chronic joint inflammation and pain. Although several therapies exist, a deeper knowledge of this disease is required to improve the lives of patients living with this chronic illness. Here we will apply new knowledge of an immune cell type we identified in patient tissues to further understand the mechanisms of the disease and how to guide development of novel therapies.

PI_NAMEs: DONLIN, LAURA T. (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Adult;Affect;American;angiogenesis;Architecture;Arthralgia;Autoimmune;Autoimmune Diseases;Automobile Driving;Biological Assay;Biological Models;Blocking Antibodies;bone;Cartilage;CD8-Positive T-Lymphocytes;Cell Culture Techniques;cell type;Chronic;Chronic Disease;Clinical;Coculture Techniques;Complex;cytokine;Data;Development;Dinoprostone;Disease;DTR gene;EGF gene;Epidermal Growth Factor Receptor;Epiregulin;Exhibits;Experimental Models;Feedback;Fibroblasts;Functional disorder;Generations;Human;human disease;Hypoxia;Immune;improved;Inflammation;Inflammatory;inhibitor;inhibitor therapy;innovation;intercellular communication;Interferon Type II;Interferons;Invaded;joint inflammation;Joints;knock-down;Knowledge;Ligands;Lymphocytic Infiltrate;Macrophage;Mediator;Methods;Molecular;novel;novel therapeutics;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Population;prevent;Printing;Prostaglandins;Publications;Reagent;Reporting;response;Rheumatoid Arthritis;secretase;Shapes;single-cell RNA sequencing;Small Interfering RNA;Sorting;Synovial Cell;Synovial Fluid;Synovial joint;Synovial Membrane;Synovitis;System;Testing;therapy development;Thromboplastin;Tissues;Translating

PROJECT_TITLE: Macrophages in human autoimmune tissue pathology

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE

PI_NAMEs: BACCALA, ROBERTO G (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: Acceleration;Affect;Age;anergy;Arthralgia;Autoantibodies;Autoantigens;Autoimmune;Autoimmunity;autoreactive B cell;autoreactive T cell;B-Lymphocytes;Chronic;chronic infection;Critical Pathways;cytokine;Defect;Disease;Environmental Exposure;Environmental Risk Factor;Epidemiology;Exanthema;Exposure to;Fatigue;Fever;Gene Deletion;Gene Expression Profile;General Population;Genetic;Genetic Predisposition to Disease;genetic risk factor;Heterogeneity;human disease;Human Herpesvirus 4;Immune;immune activation;Immune system;Immune Tolerance;Individual;Infection;Infectious Agent;Inflammasome;Inflammation;Inflammatory;Inhalation;innate immune pathways;Interferon Type I;Kidney Failure;Lead;Life;Link;Lupus;Lymphocytic choriomeningitis virus;Mediating;Modeling;Monozygotic twins;mortality;mouse model;Mouse Strains;Mus;Nucleic Acids;Occupational Exposure;Onset of illness;Organ;Pathogenesis;Pathway interactions;Patients;peripheral tolerance;Predisposition;Prevalence;Production;prototype;Pulmonary Inflammation;Quality of life;Receptor Activation;Role;Self Tolerance;Severities;Signal Transduction;Silicon Dioxide;Silicosis;synergism;System;systemic autoimmune disease;systemic autoimmunity;Systemic Lupus Erythematosus;T-Lymphocyte;Time;Toll-like receptors;Transgenic Mice;Transgenic Organisms;Virus;Virus Diseases;virus genetics

PROJECT_TITLE: Synergistic effects of silica exposure, virus infection and genetic predisposition in systemic autoimmunity

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


ORG_CITY: LEXINGTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE  The proposed research is relevant to public health because synaptic dysfunction is associated with many neurological disorders that lack effective therapeutic options. Moreover, understanding the signaling proteins that promote synaptic development will provide significant advances in our knowledge of how the nervous system is organized. Therefore, the proposed research is relevant to NIH’s mission to seek fundamental knowledge about living systems and to reduce illness and disability.

PI_NAMEs: LAMB, REAGAN ELIZABETH MAYFIELD (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Acceleration;Acetylcholinesterase Inhibitors;Actins;Address;Affect;Aldicarb;Animals;anxiety reduction;Appearance;Auxins;Behavior;Biological Assay;Biological Models;Biosensor;brain morphology;Caenorhabditis elegans;Calcium;Cholinergic Receptors;cholinergic synapse;Complementary DNA;connectome;Copy Number Polymorphism;Cytoskeletal Modeling;Data;Defect;density;Development;disability;Disease;Dissociation;Docking;Epilepsy;Exposure to;F-Actin;Fluorescence Microscopy;Functional disorder;Future;Genetic Diseases;Genetic Engineering;genetic manipulation;Genome;Goals;GTP Binding;GTPase-Activating Proteins;Guanine;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Heritability;Homologous Gene;Hydrolysis;Image;Imaging Techniques;in vivo;insight;Knowledge;Location;Long-Term Potentiation;Malignant Neoplasms;Mammals;Measures;Mediating;member;Mission;Molecular;Morphology;mouse model;Mus;mutant;Mutation;Nature;Nervous System;Nervous System Disorder;Neuromuscular Junction;neuronal circuitry;Neurons;new therapeutic target;non-invasive imaging;Organism;Pathway interactions;Patients;Phenotype;polymerization;Polymers;Population;presynaptic;Presynaptic Terminals;Proteins;Public Health;RAPGEF2 gene;Research;restoration;Role;Schizophrenia;Series;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Signaling Protein;Stereotyping;Synapses;synaptic function;Synaptic Transmission;Synaptic Vesicles;System;Testing;Therapeutic;therapeutically effective;Tissues;Transmission Electron Microscopy;United States National Institutes of Health;Vesicle;Work

PROJECT_TITLE: Role of C. elegans RAPGEF in Synapse Development at the Neuromuscular Junction


ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECT NARRATIVE Ischemia following acute brain injury has been identified as one of the leading causes of transitioning vulnerable penumbra to damaged tissue, but understanding specific mechanisms of injury has lagged far behind. Spreading depolarizations (SDs) have been identified as key contributors to injury progression through a many underexplored cellular mechanisms and thus pose as the best area for preclinical exploration. This proposal seeks to understand the relationship between excessive SD-mediated L-type Ca2+ channel activation, Zn2+ release and subsequent post-synaptic uptake, and initiation of downstream cellular injury.

PI_NAMEs: BENNETT, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acute Brain Injuries;Address;Animal Model;Area;Blood Vessels;Brain;Brain Injuries;brain tissue;Cations;cell injury;Cells;Cerebrovascular Circulation;Cessation of life;chelation;Clinical;Clinical Trials;clinically relevant;Complex;Distal;Electrophysiology (science);Event;excitotoxicity;experimental study;extracellular;Failure;fluorescence imaging;Future;Gene Modified;Glutamates;Goals;Homeostasis;Hour;hypoperfusion;imaging approach;Imaging Techniques;improved;in vivo;in vivo Model;Induced Neurons;Infarction;Injury;Intervention;Intervention Studies;Ischemia;Ischemic Stroke;knock-down;Knock-out;Link;Literature;Measures;Mediating;Metabolic;Methods;Modeling;Mus;N-Methylaspartate;Neuronal Injury;Neurons;neuroprotection;neurotoxic;novel;novel strategies;Outcome;Pathway interactions;Patients;pharmacologic;postsynaptic;pre-clinical;presynaptic;prevent;Prevention;Proteins;receptor;Recovery;Research;Role;Slice;Source;Stroke;stroke model;System;Testing;Therapeutic Intervention;therapeutic target;Tissues;Toxic effect;Translating;uptake;voltage;Work

PROJECT_TITLE: Non-canonical mechanisms of excitotoxicity


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Alzheimer’s disease (AD) is the most common form of dementia and affects as many as six million Americans, with incidence increasing with lifespan and healthcare costs astronomical. Because amnestic mild cognitive impairment (aMCI) can often precede conversion to full AD, with accelerated and debilitating memory deficits, it is increasingly important to develop therapies that can restore memory function in aMCI subjects prior to conversion and grant a multipronged understanding of the neural basis for aMCI as a precursor to AD. We will combine structural and functional magnetic resonance imaging, scalp electroencephalography, genetic testing, and image-guided theta-burst transcranial magnetic stimulation to improve memory function in elderly individuals with aMCI and elucidate individual differences and functional changes underlying clinical improvements, aiding the development of individually tailored noninvasive therapies for restoring memory function and contributing to our knowledge of the functional bases of memory in the coherence and dynamic evolution of brain networks.

PI_NAMEs: LEUCHTER, ANDREW F (contact)

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: Acceleration;Acetylcholine;Adult;Affect;Aftercare;Age;age related;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;amnestic mild cognitive impairment;Area;Astronomy;Atrophic;base;Behavioral;Brain;Clinical;Cognition Disorders;Complex;Data;Dementia;Deterioration;Development;Discrimination;Dose;dynamical evolution;Early Intervention;Elderly;Electroencephalography;Episodic memory;follow-up;Functional Magnetic Resonance Imaging;Generations;Genetic;Genetic Risk;genetic testing;Grant;Health Care Costs;high risk;Hippocampus;Human;image guided;improved;Incidence;Individual;Individual Differences;innovation;Intervention;Lateral;Life;life span;Long-Term Potentiation;Measures;medial temporal lobe;Memory;Memory Disorders;Memory impairment;Memory Loss;Methods;mild cognitive impairment;Monitor;Multimodal Imaging;neural;neurogenesis;neuroimaging;neuronal circuitry;Neurons;neuroregulation;novel;novel therapeutic intervention;older adult;Older Population;Parietal Lobe;Participant;Patients;Persons;Physiological;Prediction of Response to Therapy;Prefrontal Cortex;prevent;programs;progression risk;Randomized;Research;Resolution;Resources;response;restoration;Risk;Rodent;Role;Scalp structure;Site;Societies;Structure;Symptoms;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapy development;time use;Transcranial magnetic stimulation;treatment duration;white matter;young adult

PROJECT_TITLE: Network-targeted theta-burst stimulation for episodic memory improvement in mild cognitive impairment


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Nutrition;Obesity;Substance Misuse

ORG_CITY: NEW ORLEANS

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: Project Narrative This NRSA F30 fellowship will provide an invaluable training opportunity for a future physician scientist as she develops into an emerging leader in the field of alcohol-related liver injury. The proposed studies will investigate alcohol and calorie-dense diet-mediated disruption of hepatic mitochondrial processes and lipid handling. The findings from these studies will provide correlative and mechanistic insight for future translational studies and therapeutic applications aiming to alleviate the combination of alcohol and metabolic-induced liver injury.

PI_NAMEs: GALLEGOS, EDEN MCMILLIN (contact)

PROGRAM_OFFICER_NAME: DUNTY, JR, WILLIAM

PROJECT_TERMS: Alcohol consumption;alcohol effect;alcohol measurement;alcohol response;alcohol risk;Alcoholic beverage heavy drinker;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Antioxidants;biobank;Bioenergetics;Biogenesis;Biological Assay;Calories;career;career development;Cell Culture Techniques;cell injury;Cells;Cellular Structures;Characteristics;Cholesterol;Chronic;Cirrhosis;Citric Acid Cycle;clinically relevant;Coin;Consensus;Consumption;Data;Dedications;Development;Diet;dietary control;Disease;drinking;Ensure;Environment;Ethanol;Fatty acid glycerol esters;Fatty Liver;fatty liver disease;Fellowship;Fostering;Functional disorder;Future;Gene Expression;Genes;Genus Hippocampus;Goals;Health;Health Sciences;Hepatic;Hepatocyte;High Fat Diet;Histology;HIV;Immune;Immunofluorescence Immunologic;improved;In Vitro;in vitro Model;Incidence;insight;interest;International;Laboratories;Learning;lentivirally transduced;Lipids;Literature;Liver;liver biopsy;liver injury;Liver Mitochondria;liver transplantation;Louisiana;Macaca;Mediating;Medical;Medicine;Mentors;Metabolic;Metabolic Diseases;metabolic-associated fatty liver disease;Mitochondria;Mitochondrial DNA;Modeling;National Research Service Awards;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;Nutrient;Obesity;Organ;organ injury;Organelles;overexpression;Overweight;oxidation;Oxidative Phosphorylation;Palmitic Acids;Patients;Peroxisome Proliferator-Activated Receptors;Persons;Physicians;pre-clinical;pre-clinical research;Primary carcinoma of the liver cells;Process;Production;Publishing;Reactive Oxygen Species;receptor;Research;Research Personnel;Risk;Rodent Model;saturated fat;Scientist;SIV;Skeletal Muscle;spheroids;Stress Tests;success;Sucrose;sugar;Technology;Testing;Training;training opportunity;translational study;translational therapeutics;Transplantation Surgery;Triglycerides;UCP2 protein;Universities;Western Blotting;Work

PROJECT_TITLE: Alcohol and calorie-dense diet-mediated hepatic mitochondrial dysregulation


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE We have uncovered novel non-IgE mechanisms of mast cell activation driven by environmental particulates that will be further investigated in this proposal. Specifically, we will examine redox-independent and - dependent roles of thioredoxin interacting protein (Txnip) in regulating non-IgE mast cell activation. Our findings will be further explored in patients with chronic idiopathic urticaria, a mast cell activation disorder that is largely driven by non-IgE mechanisms, to define a role for Txnip in mast cell activation by particulates.

PI_NAMEs: BROWN, JARED MICHAEL (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: adaptive immunity;Adverse effects;adverse outcome;Air Pollution;Allergens;animal data;anti-IgE;arm;Arrestins;Autoimmunity;blood glucose regulation;Blood Vessels;Cardiovascular Diseases;Cardiovascular system;CD34 gene;Cell Degranulation;Cell Physiology;Cells;Chronic;Communication;cytokine;Cytoplasmic Granules;Data;Disease;Disease Outcome;Environmental Exposure;Environmental Health;environmental particulate;Etiology;Exocytosis;first responder;Funding;G-Protein-Coupled Receptors;Genes;Genetic;genome wide association study;glucose metabolism;Glycolysis;Goals;granule cell;Human;Hybrids;Hypersensitivity;IgE;Immune response;immune system function;immunoregulation;In Vitro;Inflammation;Inflammatory;Innate Immune System;Lung;Lung Diseases;Malignant Neoplasms;Mass Spectrum Analysis;mast cell;Mediating;Mouse Strains;Mucous Membrane;Mus;nanoengineering;nanomaterials;nanoparticle;Natural Immunity;Nerve Degeneration;Nervous System;novel;omalizumab;Outcome;Oxidation-Reduction;particle;Particulate;Particulate Matter;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Phase;Physiological;Post-Translational Protein Processing;Predisposition;Production;protein function;Proteins;Proteomics;Pulmonary Heart Disease;Regulation;Research;response;Role;sensor;Sensory;Signal Transduction;Silicon Dioxide;Silver;stem cells;Sulfhydryl Compounds;Surface;System;Testing;Tissues;tool;Toxic Environmental Substances;transcriptome sequencing;transcriptomics;TXN gene;TXNIP gene;Up-Regulation;Urticaria;Work;Xenobiotics

PROJECT_TITLE: Mechanisms of non-IgE Mast Cell Activation by Environmental Particulates


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Pediatric;Serious Mental Illness;Women's Health Research

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Lack of perceived control, particularly during stress, has been critically implicated in major depressive disorder (MDD) and anhedonic symptoms, especially among female adolescents; yet the neural underpinnings of perceived control disruptions in MDD remain poorly understood. Using functional magnetic resonance imaging with a novel “value of control task” in conjunction with a prospective design, this study will provide a comprehensive understanding of stress and perceived control related mechanisms in female adolescents with MDD and will examine stress-induced disruptions in perceived control as a predictor of “real world” expressions of maladaptive coping and anhedonia. This work is aligned with NIMH’s Strategic Objective 1 Strategy 1.1 (Describe the molecules, cells, and neural circuits associated with complex behaviors) and Strategic Objective 2 Strategy 2.2. (Identify useful biomarkers and behavioral indicators that predict change across the trajectory of illness) and may facilitate the identification of MDD biomarkers that could assist with earlier detection of adolescents vulnerable to MDD.

PI_NAMEs: BELLEAU, EMILY  (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Adolescence;Adolescent;Adult;Anhedonia;Behavior;Behavioral;biological adaptation to stress;Biological Markers;career;Cells;child depression;comparison control;Complex;Computers;control trial;coping;Data;depressive symptoms;design;Development;Disease;Dopamine;Early Diagnosis;Ecological momentary assessment;Evaluation;Exhibits;experience;Female;Female Adolescents;Functional disorder;Functional Magnetic Resonance Imaging;Future;Goals;hedonic;Human;Hydrocortisone;Image;indexing;interest;Knowledge;Life Stress;Link;Major Depressive Disorder;male;Maps;Measures;Mediating;Mentors;Mentorship;National Institute of Mental Health;negative affect;neural;neural circuit;neural correlate;Neuroanatomy;Neurobiology;neuroimaging;neuromechanism;neuroregulation;novel;Onset of illness;Participant;Pathway interactions;Pattern;peer;perceived stress;Perception;Persons;Pilot Projects;Play;Population;preclinical study;Predisposition;Prefrontal Cortex;prospective;Protocols documentation;Psychosocial Stress;recruit;Reporting;Research;response;reward processing;Rewards;Scanning;Severities;Statistical Models;Stress;stress symptom;stressor;Symptoms;Time;Training;Ventral Striatum;vulnerable adolescent;Work

PROJECT_TITLE: Neural Correlates of Stress and Perceived Control in Adolescent Depression

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Infectious Diseases;Malaria;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: MUTARE

ORG_COUNTRY: ZIMBABWE

ORG_FIPS: ZI

ORG_NAME: AFRICA UNIVERSITY

PHR: Project narrative Owing to the scale-up of control interventions, malarial burden has significantly declined in Zimbabwe and other endemic countries in the past ten years. However, the decline has been heterogeneous and a new setback of reinvasion from malarious to former malaria-free areas, including highly populated cities, is emerging. The goal of the proposed project is to employ robust molecular and field approaches to ascertain the vector, parasite and host-related determinants of urban malaria in order to identify targets for control interventions to restore malaria-free status. The project will leverage on existing malaria surveillance collaboration with the Ministry of Health and Childcare and its partners and will incorporate evaluation of control interventions over time. It also lays groundwork for development of larger follow-up research gearing towards ultimate attainment of malaria elimination by the country which is a member of the malaria elimination-8 (E-8) block.

PI_NAMEs: MHARAKURWA, SUNGANO  (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Affect;Africa;African;Altitude;Area;Award;Awareness;Back;Behavior;Biological Assay;Biology;Blood;Breeding;burden of illness;career;career development;Characteristics;Chemoprophylaxis;Child Care;Cities;Collaborations;Collection;Communication;Communities;Conduct Clinical Trials;Country;Culicidae;Data;Data Analyses;design;Detection;Development;Diagnosis;diagnostic accuracy;Disease;Drug resistance;Dryness;Ensure;Epidemiologic Factors;Epidemiology;Evaluation;experience;Feeding behaviors;follow-up;Genetic;Genomics;Goals;Grant;Habitats;Health;Health care facility;Healthcare;histidine-rich proteins;Human;indexing;Infection;Insecticides;International;Intervention;intervention program;Invaded;Laboratories;Lead;Malaria;malaria transmission;Measures;member;Mentors;Molecular;Molecular Analysis;Molecular Epidemiology;molecular marker;Monitor;Morphology;multidisciplinary;operation;Parasites;Parasitology;Pattern;Plasmodium falciparum;Predisposition;Prevalence;Preventive measure;Preventive treatment;Privatization;programs;Prophylactic treatment;Public Health;Publications;Recommendation;Research;Research Personnel;Research Project Grants;Residual state;restoration;Risk;Risk Factors;Sampling;Sanitation;scale up;Seasons;Sentinel;Site;Southern Africa;Specimen;Spottings;suburb;Surveillance Program;Surveys;symposium;Temperature;Testing;Time;Translational Research;transmission process;Travel;Universities;uptake;vector;vector control;vector mosquito;Work;Writing;Zimbabwe

PROJECT_TITLE: Epidemiology of Malaria Invasion in  Mutare  City and Targets for Elimination, Zimbabwe

STUDY_SECTION_NAME: International and Cooperative Projects - 1 Study Section[ICP1]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: VA MEDICAL CENTER - LEXINGTON, KY

PHR: Pulmonary fibrosis is a devastating illness that involves progressive remodeling and scarring of lung tissue that can eventually lead to poor gas exchange. The incidence of idiopathic pulmonary fibrosis is increasing worldwide, including among Veterans, mortality rates are high, and the average life expectancy is 3 to 5 years after diagnosis. This proposed study will investigate a previously unrecognized mechanistic pathway that contributes to the development of pulmonary fibrosis and will identify potential targets for therapeutic intervention to reduce fibrosis.

PI_NAMEs: WATERS, CHRISTOPHER M (contact)

PROJECT_TERMS: Acute Lung Injury;Aging;Alveolar;alveolar epithelium;Apoptosis;Bleomycin;Cell Culture Techniques;Cell Line;Cessation of life;Chronic Disease;COVID-19 survivors;Data;Death Rate;Development;Diagnosis;Disease;Disease Progression;Environmental Risk Factor;Epithelial Cells;epithelial injury;epithelial repair;Epithelium;Estrogen Receptors;Exposure to;Extracellular Matrix;Extracellular Signal Regulated Kinases;Female;Fibroblasts;Fibrosis;fibrotic lung;Gases;Goals;Gonadal Steroid Hormones;Hyperoxia;idiopathic pulmonary fibrosis;improved;Incidence;Inflammation;inhibitor;Injury;JUN gene;knock-down;Knowledge;Life Expectancy;Lipopolysaccharides;lung injury;Macrophage;male;MAP Kinase Gene;MAP Kinase Kinase Kinase;MAP3K5 gene;MAPK3 gene;MAPK8 gene;Mechanical ventilation;Mediating;Mediator;men;Mesenchymal;Modeling;Molecular Abnormality;Morbidity - disease rate;mortality;mouse model;Mus;Myofibroblast;NADPH Oxidase;new therapeutic target;nintedanib;novel;novel therapeutic intervention;novel therapeutics;Oxidative Stress;Oxygen;p38 Mitogen Activated Protein Kinase;Pathogenicity;Pathway interactions;Patients;Phosphothreonine;Pirfenidone;Prevalence;Process;Prognosis;Proteins;Pulmonary Fibrosis;Regulation;Reporting;Research;Resistance;response;Role;severe COVID-19;sex;Sex Differences;Signal Pathway;Signal Transduction;Survivors;targeted treatment;Testing;Therapeutic Intervention;therapeutic target;Tissues;Transforming Growth Factor beta;TXN gene;Veterans;Woman

PROJECT_TITLE: Sex differences in ASK1-mediated pulmonary fibrosis


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

PHR: This research is relevant to public health because it will identify a potential new molecular mechanism through which pathogens like P. gingivalis could be specifically manipulating epithelial innate responses to alter normal host-bacteria interactions at mucosal surfaces that will evolve to dysbiosis, persistent infection and inflammatory disease. Positive findings of these studies will provide new opportunities for the development of innovative approaches to prevent/treat periodontal disease and its potential adverse effects in systemic health.

PI_NAMEs: GONZALEZ, OCTAVIO ALBERTO (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: adaptive immunity;Address;Adverse effects;Agreement;Animal Model;Anti-microbial susceptibility;antimicrobial;Antimicrobial Effect;Apoptosis;Autophagocytosis;Bacteria;bone loss;Cell Physiology;Cell Proliferation;Cells;chemokine;chronic infection;chronic inflammatory disease;Clinical;Complex;Data;Development;Disease;dysbiosis;Eating;Ecology;Enzymes;Epithelial Cells;Epithelium;Event;Exhibits;Firmicutes;Gene Expression;gingipain;Gingiva;Health;Human;Immune;In Vitro;in vivo;Inbred BALB C Mice;Infection;Inflammation;Inflammatory;innovation;Knowledge;Lesion;Macrophage;malignant mouth neoplasm;Mediating;Microbe;microbial;microbial community;microbiota;Modeling;Molecular;mouse model;Mouse Strains;Mucosal Immunity;Mucous Membrane;Mus;Mutation;Natural Immunity;nonhuman primate;notch protein;Oral;oral cavity epithelium;Oral health;oral microbiome;oral pathogen;overexpression;pathogen;Pathogenicity;Pathway interactions;Periodontal Diseases;Periodontitis;Phospholipase A2;PLA2G2A gene;Play;Porphyromonas gingivalis;prevent;Property;Proteobacteria;Public Health;receptor;Receptor Activation;recruit;Reporting;Research;Research Design;Resistance;response;Role;Surface;Testing;Time;Transgenic Mice;Variant

PROJECT_TITLE: Role of Notch-1/PLA2-IIA in oral dysbiosis, inflammation, and periodontal disease

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Sexually Transmitted Infections;Urologic Diseases;Vaccine Related

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative: Neisseria gonorrhoeae causes sexually transmitted infections, and rising levels of antibiotic resistance in the bacteria as well as rising case rates have created an urgent need for infection prevention. Observational studies in humans and preclinical work in mice indicate that a vaccine approved for use in the US to prevent infections caused by the related bacteria, Group B Neisseria meningitidis (4C-MenB), may provide partial protection against N. gonorrhoeae infection. We propose a randomized controlled trial with a unique experimental human infection model to test the effectiveness of 4C-MenB in preventing N. gonorrhoeae infection in men.

PI_NAMEs: DUNCAN, JOSEPH A (contact)

PROGRAM_OFFICER_NAME: CHUANG, ELEANORE JENNIFER

PROJECT_TERMS: Address;Antibiotic Resistance;antibiotic resistant infections;Antibiotic Therapy;Antibiotics;Antibodies;Antigens;antimicrobial;Antimicrobial Resistance;arm;Atopobium vaginae;Bacteria;bactericide;Biological;Case/Control Studies;Chlamydia trachomatis;Clinical Trials;combat;Country;cross immunity;Cuba;Data;Development;Diphtheria;Disease;Drug-resistant Neisseria Gonorrhoeae;effectiveness testing;efficacy testing;epidemiologic data;Exhibits;Exposure to;FDA approved;flu;Future;Goals;Gonorrhea;gonorrhea vaccine;high risk population;Homologous Gene;Human;human male;Immune;Immune Evasion;Immune response;Immunity;Immunization;Immunize;Immunoglobulin A;Immunoglobulin G;Immunoglobulin M;Immunologics;Incidence;Individual;Infection;Infection prevention;Influenza A virus;influenza virus vaccine;Knowledge;Mass Vaccinations;Membrane;men;Meningococcal vaccine;Modeling;Monoclonal Antibodies;Mus;Natural Immunity;Neisseria gonorrhoeae;Neisseria meningitidis;New Zealand;Norway;Observational Study;Outcome;Participant;pathogen;Pathogenesis;pathogenic bacteria;pre-clinical;prevent;Prevention;protective effect;Public Health;randomized trial;Randomized, Controlled Trials;Recombinants;Recommendation;Regulatory T-Lymphocyte;Reporting;Request for Proposals;Research;Research Design;Resistance;response;Risk;Schedule;Serogroup B Neisseria meningitidis;Serum;Sexual Transmission;Sexually Transmitted Diseases;Specimen;stem;Testing;Tetanus;Time;trial comparing;United States;unvaccinated;Upper respiratory tract;Urethra;Urethritis;Vaccination;vaccine development;vaccine effectiveness;vaccine platform;Vaccines;vaginal infection;Vesicle;Work;young adult;young man

PROJECT_TITLE: Efficacy of immunization with 4C-MenB in preventing experimental urethral infection with Neisseria gonorrhoeae.


NIH_SPENDING_CATS: Cardiovascular;Contraception/Reproduction;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: WINSTON-SALEM

ORG_DEPT: SURGERY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Our studies will establish an important role for the apelin receptor system in normal and pathological pregnancy. These studies will unveil the molecular mechanisms involved in the regulation of trophoblast function associated with normal pregnancy, provide insights into the pathology of the hypertensive pregnancy disorder preeclampsia, and contribute to our understanding of the adverse effects of downregulated apelin receptor system leading to abnormal uteroplacental development in preeclampsia.

PI_NAMEs: YAMALEYEVA, LILIYA M (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Address;Adverse effects;angiogenesis;antagonist;APLN gene;Arteries;Attenuated;Biochemical;blood pressure reduction;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;Cell Line;cell motility;Cell Separation;Cells;Child;Chorionic villi;Circulation;Clinical;Data;Decidua;Development;Disease;Down-Regulation;early pregnancy;Embryonic Development;Event;Exhibits;Exposure to;Extracellular Signal Regulated Kinases;fetal;Fetal Growth;Fetal Growth Retardation;Functional disorder;Genomics;Goals;hemodynamics;Heterogeneity;Human;Hypertension;hypertensive;improved;Incidence;insight;interdisciplinary approach;Invaded;Investigation;Knockout Mice;Knowledge;Life;Ligands;malformation;MAP Kinase Gene;maternal morbidity;Maternal-Fetal Exchange;Mediating;Messenger RNA;migration;Mitogen-Activated Protein Kinases;Modeling;Molecular;novel;novel therapeutics;overexpression;Pathogenesis;Pathologic;Pathology;Pathway interactions;Peptides;pharmacologic;Phenotype;Phosphotransferases;Physiological;Placenta;Placentation;Plasma;population health;Pre-Eclampsia;Pregnancy;pregnancy disorder;Premature Birth;prevent;Preventive;Proliferating;Property;protective pathway;Protein Isoforms;Proteinuria;Publishing;Rattus;receptor;Regulation;Role;Signal Pathway;Signal Transduction;Syndrome;System;Techniques;Technology;Therapeutic;Therapeutic Intervention;therapeutic target;therapy development;Tissues;transcriptome sequencing;trophoblast;Uterus;Woman

PROJECT_TITLE: Endogenous Apelin Receptor Ligands and Early Stages of Preeclamptic Pregnancy

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]