ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases;Skin Cancer

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE Non-Hodgkin lymphoma (NHL) is the most common cancer that develops from cells of the blood system, and while outcomes for B-cell lymphoma patients have improved dramatically, similar progress has not been made against peripheral T-cell (PTCL) and cutaneous T-cell (CTCL) lymphomas, where survival after relapse in the former, and in some subtypes of the latter, even after diagnosis, remains less than one year. We identified Heat shock protein (HSP)-70 as being highly expressed by models of both PTCL and CTCL, developed a panel of antibodies of which one, known as clone 239-87, specifically recognizes HSP70 only on cancerous T- cells but not normal T-cells, and found that this antibody showed promising activity against both PTCL and CTCL models as an antibody-drug conjugate (ADC), and as a chimeric antigen receptor (CAR) guided T-cell. Further studies are proposed that will broaden our understanding of the role of HSP70 in T-cell lymphomas, study the activity of various HSP70-targeted ADCs and CAR T-cells both alone, and in rationally designed combinations against cell lines, and validate the efficacy of the best approaches in vivo, with the ultimate goal of moving at least one of these to the clinic to improve outcomes of the many patients with PTCL and/or CTCL who need new treatment options.

PI_NAMEs: IQBAL, JAVEED ;ORLOWSKI, ROBERT ZYGMUNT (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Address;Adoptive Cell Transfers;African;African ancestry;Amanitins;anaplastic lymphoma kinase;Antibodies;Antibody-drug conjugates;Area;Asian;B-Cell Lymphomas;B-Cell NonHodgkins Lymphoma;B-Lymphocytes;beta-Chemokines;Binding;Biological Assay;biomarker driven;Blood;cancer cell;Cancerous;CAR T cell therapy;Cell Line;Cell model;Cell surface;Cells;Cellular biology;chemokine receptor;chimeric antigen receptor;chimeric antigen receptor T cells;Classification;Clinic;Clinical;Codon Nucleotides;Country;Cutaneous;Cutaneous T-cell lymphoma;cytotoxicity;Data;Deacetylase;Development;Diagnosis;differential expression;Disease;Dose;Doxorubicin;Drug Approval;Effectiveness;efficacy evaluation;efficacy validation;Exclusion;experimental study;Gene Expression;Gene Expression Profiling;Genetic;Genomic approach;Genomics;Goals;Growth;Heat-Shock Proteins 70;Hematologic Neoplasms;Heterogeneity;Human;Immunophenotyping;improved;improved outcome;In Vitro;in vitro activity;in vitro Model;in vivo;in vivo Model;Incidence;Industry;inhibitor;Interferons;Janus kinase;Ki-1 Large-Cell Lymphoma;kinase inhibitor;Link;lymph nodes;Lymphoma;Malignant Neoplasms;Mediator;Medical;Membrane;Messenger RNA;Modeling;Molecular;Molecular Profiling;Monoclonal Antibodies;Morphology;Mus;Mycosis Fungoides;neoplastic;new therapeutic target;Non-Hodgkin's Lymphoma;non-Hodgkin's lymphoma patients;Normal Cell;Normal tissue morphology;novel;novel therapeutics;Nuclear;Oncogenes;Oncogenic;Outcome;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;Pattern;Peripheral;peripheral blood;Pharmaceutical Preparations;Physiological;Population;Prognosis;Protein Overexpression;Proteome;Proteomics;rational design;Regimen;Relapse;Research;Role;Sampling;Schedule;Sezary Syndrome;Signal Transduction;Skin;STAT protein;statistics;Subgroup;synergism;System;T cell therapy;T-Cell and NK-Cell Neoplasm;T-Cell Lymphoma;T-Lymphocyte;Testing;Therapeutic;Therapeutic Monoclonal Antibodies;therapeutic target;Thymus Gland;TNFRSF8 gene;transgene expression;translational approach;tumor;United States;Variant;vector;Vorinostat;Work;Xenograft procedure

PROJECT_TITLE: Role of Heat Shock Protein 70 as a Mediator and Therapeutic Target in T-cell Lymphomas

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Genetics;Lymphatic Research;Lymphedema

ORG_CITY: TAMPA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHYSIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Congenital lymphedema is associated with swollen extremities, disfigurement, skin infections, and sepsis that is caused by inherited gene mutations, most commonly in the gene encoding VEGFR3. The pathogenesis of congenital lymphedema is unknown, precluding the development of pharmacological therapies for these patients. This proposal utilizes knockout and heterozygous VEGFR3 mice to identify and investigate a new mechanism inhibiting interstitial fluid absorption in congenital lymphedema.

PI_NAMEs: SCALLAN, JOSHUA PAUL (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: absorption;Address;Adherens Junction;Affect;Beds;Binding;Biological Process;Birth;Blood Vessels;Breast Cancer Patient;cadherin 5;Cell Culture Techniques;Cells;Cellulitis;clinically relevant;comorbidity;Data;Development;Disease;drug development;Ear;effective therapy;Embryo;Excision;Fibrosis;FLT4 gene;Functional disorder;Gene Mutation;Genes;Hereditary lymphedema;Heterozygote;Hindlimb;Image;Impairment;in vitro Model;in vivo;Infectious Skin Diseases;Inherited;insight;Intercellular Fluid;Intercellular Junctions;KDR gene;knock-down;Knock-out;Knockout Mice;Knowledge;Laboratories;Leg;Life;Ligands;Limb structure;Link;Liquid substance;Lymph;lymph flow;lymph nodes;Lymphangiogenesis;Lymphatic;Lymphatic Capillaries;lymphatic dysfunction;Lymphatic function;lymphatic malformations;lymphatic vasculature;lymphatic vessel;Lymphedema;lymphoscintigraphy;Maintenance;Malignant Neoplasms;Messenger RNA;methicillin resistant Staphylococcus aureus;Missense Mutation;Modeling;Molecular;mouse model;Mus;Mutation;Near-infrared optical imaging;new growth;notch protein;novel;Outcome;overexpression;Pathogenesis;Patients;Persons;pharmacologic;Pharmacological Treatment;Pharmacotherapy;Physiological;postnatal;Predisposition;Protein Isoforms;Proteins;receptor;Receptor Protein-Tyrosine Kinases;Respiratory Diaphragm;Role;Sepsis;shear stress;Signal Pathway;Signal Transduction;Skin;Swelling;Syndrome;Tail;Testing;Tissues;Tracer;Vascular Endothelial Growth Factor Receptor-1;Vascular Endothelial Growth Factor Receptor-3;Vascular Endothelium;VEGFC gene;virtual;Work

PROJECT_TITLE: VEGFR Signaling Controls Lymphatic Junctions

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PI_NAMEs: DOBRENIS, KOSTANTIN  (contact)

PROJECT_TERMS: Address;Anatomy;Animal Experiments;Animals;Back;base;behavioral phenotyping;Biological Assay;Brain;brain cell;Cell Line;Cell model;cell preparation;Cell Separation;Cells;cellular engineering;cellular imaging;clinical phenotype;Cognitive;college;Computer software;Computer Workstations;computerized data processing;Consultations;Correlation Studies;Coupled;Custom;data acquisition;Data Analyses;design;differentiation protocol;Disease;Dissection;Electrophysiology (science);Embryo;Epigenetic Process;Equipment;Evaluation;Experimental Designs;Faculty;fetus cell;Funding;Gene Expression;Gene Targeting;gene therapy;Generations;Genetic;Goals;Grant;high end computer;high standard;Human;human induced pluripotent stem cells;Image;Image Analysis;image processing;image reconstruction;imaging software;In Situ;In Vitro;in vivo;Individual;induced pluripotent stem cell;Injections;innovation;instrument;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;interest;Investigation;Investments;Laboratories;Lasers;Leadership;Microscope;Microscopy;Modernization;Modification;Molecular;Monitor;mouse model;Mutation;Names;neural;neurogenomics;neuroimaging;Neuronal Differentiation;Neurons;Neurosciences;optogenetics;Organoids;Patients;Phenotype;Physiological;Preparation;Printing;Production;Productivity;Proteins;Proteomics;Protocols documentation;Publications;Quality Control;reconstruction;Research;Research Personnel;Research Project Grants;Resolution;Resource Sharing;Resources;RNA;Sampling;Schedule;Services;Slice;Specimen;Structure;Surveys;synergism;therapeutic evaluation;Therapeutic Intervention;Time;Tissue Engineering;Tissue Model;tissue preparation;tissue/cell culture;Tissues;tool;Training;translational study;treatment strategy;ultra high resolution;United States National Institutes of Health;Work

PROJECT_TITLE: NEURAL CELL ENGINEERING AND IMAGING CORE


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Prevention

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: The high comorbidity of age-related diseases in the elderly limits the benefit that can be obtained by treating any one chronic disease individually. This project seeks to determine if selective inhibition of mTORC1 can modify the fundamental biology of aging in humans and safely improve physiological function to prevent multiple age-related conditions.

PI_NAMEs: KONOPKA, ADAM R (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: Address;Adult;Adverse event;Age of Onset;age related;age related chronic disease;Age related comorbidities;age-related disease;Aging;aging biomarker;aging mechanism;aging population;aging related;Bioenergetics;Biological Markers;Biological Models;Biology of Aging;Biopsy Specimen;Blood;Blood Chemical Analysis;C-Peptide;Cardiovascular Diseases;CCI-779;cellular targeting;Chronic Disease;Clinical Trials;cognitive function;Complex;Dementia;Disease;DNA Methylation;Dose;Double-Blind Method;Elderly;Ensure;epigenetic clock;epigenomics;extend lifespan;FDA approved;frailty;FRAP1 gene;Funding;geroprotection;geroprotector;Glucose;Goals;hallmarks of aging;healthspan;healthy aging;heart function;Hematology;high risk;holistic approach;Human;Hyperactivity;immune function;immunosenescence;Immunosuppression;improved;Incidence;Individual;influenza virus vaccine;inhibitor;innovation;insight;Insulin;Insulin Resistance;Intervention;Knowledge;Lead;lipidomics;Lipids;member;Metabolic;metabolomics;middle age;Mitochondria;Molecular;Molecular Target;Morbidity - disease rate;mortality;multiple omics;Mus;Muscle;Non-Insulin-Dependent Diabetes Mellitus;older adult;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;Physical Function;Physiological;Population;predict clinical outcome;prevent;Prevention;prophylactic;Protein Kinase;Proteomics;randomized placebo-controlled clinical trial;research clinical testing;Resources;Risk;Role;Safety;Schedule;Scientist;SDZ RAD;senescence;side effect;Signal Transduction;Sirolimus;Skeletal Muscle;Specific qualifier value;Specificity;Techniques;Testing;Tissues;transcriptomics;United States;United States National Institutes of Health;Universities;vaccine efficacy;Whole Blood;Wisconsin

PROJECT_TITLE: Clinical evaluation of mTORC1 inhibition for geroprotection.


ADMINISTERING_IC: AT

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Complementary and Integrative Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE As the U.S. public expands its use of complementary, alternative and integrative health (CIH) modalities, there continues to be an important need for well-trained researchers to investigate CIH safety, efficacy, and effectiveness, as well as to explore implementation strategies for integrating effective CIH therapies into health care practice. The UNC Research Training Fellowship in Complementary and Integrative Healthcare, now in its second decade, will continue to meet the need for rigorous, interdisciplinary training of future leaders in CAM and integrative-healthcare research. The program will train young investigators in clinical research methods in mind-body and natural products research, with emphasis on high-impact research that can facilitate increased access to CIH for at-risk populations and conditions.

PI_NAMEs: FAUROT, KETURAH RUTH;GAYLORD, SUSAN  (contact);GISCOMBE, CHERYL L

PROGRAM_OFFICER_NAME: BAUMGARTNER, JENNIFER NICOLE

PROJECT_TERMS: Complementary Health;Fellowship;Healthcare;Integrative Medicine;Research Training


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Dietary Supplements;Maternal Health;Microbiome;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Infant nutritional status at birth and catch-up growth in the first 6-months of life, especially in preterm and small-for-gestational age infants, have been shown to be critical determinants of childhood growth outcomes and associated with risk for mortality, morbidity, and developmental outcomes. Studies of nutritional interventions to improve infant growth among these vulnerable infants are needed in rural, low- resource areas in South Asia, where maternal undernutrition, adverse pregnancy outcomes, and poor growth outcomes are common. If efficacious, a balanced energy protein nutritional supplement with multiple micronutrients and calcium, provided to mothers during pregnancy and lactation, could improve maternal nutrition and infant growth in their first 6 months of life and beyond.

PI_NAMEs: ERCHICK, DANIEL JOSEPH (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: Accounting;Adult;adverse birth outcomes;adverse pregnancy outcome;Age Months;antenatal care;Asia;Biological Specimen Banks;Birth;Breast Feeding;Calcium;Child;Childhood;Collaborations;Communities;Consensus;design;Detection;Development;Dietary Intervention;dietary supplements;Dose;efficacy testing;energy balance;Enrollment;evidence base;Evidence based intervention;Exclusive Breastfeeding;experience;feeding;Fetal Growth Retardation;follow-up;Food Supplements;Fortification;France;Future;Growth;gut microbiome;Health;high risk infant;Human Milk;improved;Incidence;Infant;infant outcome;Inflammation;Infrastructure;intergenerational;Intervention Trial;Lactation;Length;Life;Link;Lipids;Live Birth;low and middle-income countries;Malnutrition;Measures;Mediation;Mediator;Micronutrients;Milk;Morbidity - disease rate;mortality risk;mother nutrition;Mothers;Nepal;Neurocognitive;Newborn Infant;Nutrient;Nutritional;Nutritional status;Nutritional Study;Nutritional Support;Outcome;Parents;Pathway interactions;Performance;Policies;Population;postnatal;Postpartum Period;Pregnancy;Pregnancy loss;pregnant;Pregnant Women;Premature Birth;Prevalence;primary outcome;programs;Proteins;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;recruit;Research;Resource-limited setting;Rural;rural setting;Sample Size;Sampling;Schedule;secondary outcome;Site;Small for Gestational Age Infant;Specific qualifier value;study population;Supplementation;Systems Biology;Testing;treatment arm;Variant;wasting;Weight;Weight Gain;Woman;Work;World Health Organization

PROJECT_TITLE: Balanced Energy Protein Supplement in Early Lactation on Infant Growth in Southern Nepal

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

PI_NAMEs: SCHWARTZ, GARY J (contact)

PROJECT_TERMS: Address;Adult;Affective;Anatomy;Animal Disease Models;Animal Model;Animals;Behavior;Behavior assessment;Behavioral;behavioral phenotyping;behavioral study;Biological Assay;blood glucose regulation;Body Composition;Body Temperature;Brain;Brain imaging;career development;cellular engineering;cellular imaging;Child;clinical phenotype;cognitive function;Collaborations;Complex;Core Facility;cost effectiveness;Data;data mining;design;Development;Diffusion Magnetic Resonance Imaging;Disease;disease phenotype;Eating;Elements;Energy Metabolism;Equipment;Etiology;experience;Experimental Designs;experimental study;Faculty;Fatty acid glycerol esters;feeding;Feeding behaviors;Fostering;Genetic;Genetic Diseases;Goals;high throughput screening;Histologic;Human;human disease;Image;Imaging Techniques;Impairment;Individual;innovation;Insulin;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;interdisciplinary approach;Investigation;Leadership;Link;Logistics;Magnetic Resonance Imaging;mature animal;Measurement;Measures;Metabolic;metabolic phenotype;Metabolism;Methodology;Mission;Monitor;motivated behavior;mouse model;Mus;Mutation;neural;neurogenomics;neuroimaging;Neurons;neurophysiology;Pathogenesis;Pattern;Phenotype;Physical activity;Physiological;Positron-Emission Tomography;Postdoctoral Fellow;prevent;programs;Quality Control;Rattus;Regulation;Reproducibility;Research;Research Personnel;Research Project Grants;Resources;Rodent;Rodent Model;satisfaction;Sensorimotor functions;Social Behavior;Statistical Data Interpretation;student training;System;Techniques;Technology;Testing;Training;translational approach;whole animal imaging

PROJECT_TITLE: ANIMAL PHENOTYPING CORE


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Mental Health;Precision Medicine;Prevention;Sexually Transmitted Infections;Social Determinants of Health

ORG_CITY: MIAMI

ORG_DEPT: MISCELLANEOUS

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

PHR: PROJECT NARRATIVE We propose to conduct a novel, 5-year project to revise, update, and test a couples-based HIV/STI prevention toolkit intervention with 150 at-risk sero-concordant negative and 150 sero-discordant cisgender male couples in the US. After applying the remaining stages of the ADAPT-ITT model from our preliminary work, we will then proceed by conducting a 16-month RCT with a delayed, educational control to examine efficacy of the toolkit intervention on couples' a) formation and adherence to a risk-reduction plan and agreement; b) relationship functioning (e.g., communication, communal coping); and c) self-reported and biomarker confirmed indicators of risk (sexual behavior and STI), and engagement in HIV prevention (PrEP adherence) and care (ART adherence). We will also evaluate couples' use of the toolkit intervention over time by using three different data sources, as well as exploring the moderating and mediating effects on couples' outcomes.

PI_NAMEs: MITCHELL, JASON W (contact)

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: Adherence;Affect;Agreement;AIDS prevention;arm;binge drinking;Biological Markers;Caring;Characteristics;cisgender;Cities;commune;Communication;coping;Couples;Data;Data Sources;digital;Education;Effectiveness;effectiveness evaluation;efficacy evaluation;eHealth;Elements;Evaluation;future implementation;Goals;Health;Health behavior change;health information technology;HIV;HIV disparities;HIV Infections;HIV risk;HIV Seropositivity;HIV/STD;Home;human centered design;Human immunodeficiency virus test;hybrid type 1 trial;improved;indicated prevention;Individual;individualized prevention;innovation;Intervention;Interview;intimate partner violence;Legitimacy;Length;male;male couples;Mediating;men who have sex with men;Mental Health;Method Acceptability;Methods;Modeling;multiple data sources;novel;Outcome;Pathway interactions;Patient Self-Report;pre-exposure prophylaxis;Prevention;prevention service;Prevention strategy;preventive intervention;Process;programs;Public Health;Randomized;Randomized, Controlled Trials;Reporting;Research;response;Risk;Risk Reduction;Role;Sampling;Science;sex;Sex Behavior;Shapes;Social support;STI prevention;substance use;Testing;theories;Time;time use;transmission process;Treatment Efficacy;Update;uptake;usability;Viral;Work

PROJECT_TITLE: Personalized prevention for couples

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: STANFORD

ORG_DEPT: GENETICS

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE: Overall In the first phase of HuBMAP, we established the Stanford Tissue Mapping Center to map the complexity of cellular architecture and biomolecular profiles of the small bowel and colon ーorgans that play wide-ranging roles in maintaining normal physiologies of metabolism, immunity, and even neural function. We applied the deep expertise of our team to obtain high-quality biospecimens, characterize tissues using cutting-edge omics and multiparametric imaging techniques, and perform integrative analyses to understand the biomolecular profiles in the context of spatial tissue structure. We have scaled these data-generation and analysis pipelines for production-scale interrogation of the intestinal wall. We will continue these efforts to build three-dimensional multi-modal (snRNA, snATAC, CODEX, multiplex FISH) spatial maps that will give the greater scientific community insights into the molecular underpinnings of normal bowel function.

PI_NAMEs: NOLAN, GARRY P;SNYDER, MICHAEL P. (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: 3-Dimensional;absorption;analysis pipeline;Antibodies;Architecture;Area;ATAC-seq;Biological Assay;Biological Sciences;Blood Vessels;Cell Nucleus;cell type;Cells;Chromatin;Chromosome Mapping;Circulation;Collaborations;Collection;Colon;Communities;Complex;Consent;cost;Data;Data Set;data sharing;data submission;Deposition;Detection;Disease;Donor Selection;Educational workshop;Epithelium;Ethnic Origin;Exposure to;Fluorescent in Situ Hybridization;Food;Gene Expression;Gene Expression Regulation;Generations;Genes;Genome;genome wide association study;Genomics;graduate student;Heterogeneity;Homeostasis;Human;Human BioMolecular Atlas Program;Human body;Image;Imaging Techniques;Immune;Immunity;Immunoassay;indexing;Individual;Ingestion;insight;Intestines;Length;Lymphatic;Maps;Mediating;Metabolism;Molecular;Motility;Mucous Membrane;multimodal data;multimodality;multiparametric imaging;multiple omics;Muscle;Neighborhoods;Neurophysiology - biologic function;North Dakota;Nucleic Acid Regulatory Sequences;Nutritional;Organ;Organ Donor;Organ Transplantation;Phase;Physiology;Play;Population;Postdoctoral Fellow;Preservation Technique;Process;Production;Protocols documentation;public repository;Resolution;Resources;Role;Running;Sampling;Science;sex;Signal Transduction;single cell technology;single nucleus RNA-sequencing;Site;Slide;Small Intestines;Small Nuclear RNA;South Dakota;Structure;Submucosa;Technology;Thick;Tissue Banks;tissue mapping;Tissue Preservation;Tissue Sample;Tissue-Specific Gene Expression;Tissues;Training;transcriptome;transcriptome sequencing;transcriptomics;Tribes;Underserved Population;Work;XCL1 gene

PROJECT_TITLE: Stanford Tissue Mapping Center


NIH_SPENDING_CATS: Bioengineering;Data Science;Digestive Diseases;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: PLEVRITIS, SYLVIA KATINA (contact)

PROJECT_TERMS: 3-Dimensional;Address;analysis pipeline;Antibodies;Architecture;ATAC-seq;Benchmarking;biomarker identification;Blood Vessels;Cell Nucleus;cell type;Cells;Chromium;cloud based;Colon;Communities;computerized data processing;Data;Data Analyses;data analysis pipeline;data modeling;data quality;data standards;Enterocytes;epigenomics;experience;Fluorescent in Situ Hybridization;Funding;Genetic Markers;Genetic Transcription;Heterogeneity;Human;Human BioMolecular Atlas Program;human data;Image;Immune;Immunoassay;Infrastructure;interoperability;Intestines;Investigation;Maps;Metadata;Methods;Molecular;multimodal data;multimodality;multiple omics;multiplex assay;Muscle;Neighborhoods;neural;next generation;novel;Nuclear RNA;Ontology;open source;Organ;Phase;platform-independent;Population;Process;Production;programs;Proteins;Protocols documentation;public repository;Quality Control;Reproducibility;Resolution;Resources;RNA;single nucleus RNA-sequencing;Site;Small Intestines;software development;Software Engineering;Software Framework;Standardization;Statistical Methods;Structure;System;Thick;tissue mapping;Tissues;tool;transcriptome;transcriptomics;working group

PROJECT_TITLE: Data Analysis Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMST-U]


NIH_SPENDING_CATS: Digestive Diseases;Genetics;Human Genome;Microbiome;Precision Medicine;Transplantation

PI_NAMEs: SNYDER, MICHAEL P. (contact)

PROJECT_TERMS: 3-Dimensional;absorption;American Indian community;Antibodies;Architecture;Area;ATAC-seq;bile salts;Biological Assay;Blood Vessels;Body System;Brain Death;Cell Nucleus;cell type;Cells;Chromatin;Colon;commensal microbes;Complex;Confounding Factors (Epidemiology);Consent;Consent Forms;COVID-19 testing;Data;data integration;Data Set;Disease;Distal part of ileum;Duodenum;Enrollment;Enterocytes;ethnic diversity;Exhibits;Fluorescent in Situ Hybridization;Freezing;Functional disorder;Gastrointestinal tract structure;Gene Expression;Generations;Genes;Geography;Goals;Human;Human BioMolecular Atlas Program;human tissue;Immune;Immune system;Immunoassay;improved;Individual;Inflammatory Bowel Diseases;Intestines;Investigation;Iron;Length;Light;lipidomics;Lymphatic;Malignant Neoplasms;Maps;Metabolism;metabolomics;microbiome;Molecular;Monitor;Mucous Membrane;multimodal data;multimodality;multiple omics;Muscle;Nerve;Neurophysiology - biologic function;Nuclear;nutrient absorption;Organ;Organ Donor;Organ Procurements;Organ Transplantation;Phase;Physiological;Physiology;Policies;Population;Positioning Attribute;Precision Health;Production;programs;Protocols documentation;reconstruction;Resolution;Resources;Riboflavin;RNA;Sampling;single nucleus RNA-sequencing;Site;Small Intestines;South Dakota;spatial relationship;Standardization;Structure;Surface;System;Techniques;Thiamine;Thick;tissue mapping;Tissue Preservation;Tissues;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Transplant Surgeon;two-dimensional;Vitamin B 12;Vitamin K;whole genome;Work;working group

PROJECT_TITLE: Organ Specific Project


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Disability Research;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: PROJECT NARRATIVE  Intellectual developmental disabilities (IDD) are frequently diagnosed during early childhood and have dramatic  quality of life consequences for the affected individual and their caregiver(s). Significant insight into brain  mechanisms of IDDs can be gained by studying single gene mutation IDD conditions such as the one we focus  on here, KDM5C, with the use of animal models and human cerebral organoids. In addition to providing critical  information regarding the etiology of this cause of IDD, our work has broad implications for other known  genetic causes of IDD.

PI_NAMEs: SECOMBE, JULIE  (contact)

PROJECT_TERMS: Address;Affect;Alleles;analytical tool;Animal Model;Attenuated;behavioral phenotyping;Biological Assay;Biological Models;Brain;Caregivers;Cell Line;Cell model;Cells;Cerebrum;Chromatin;chromatin immunoprecipitation;chromatin modification;Chromatin Remodeling Factor;Clinical;clinical database;clinically relevant;Code;Cognition;Cognitive;Cognitive deficits;cohort;comorbidity;Complement;Core Facility;CRISPR/Cas technology;database of Genotypes and Phenotypes;Defect;Development;Developmental Disabilities;Diagnosis;Disease;disease model;Drosophila genus;Drosophila melanogaster;early childhood;Epigenetic Process;Etiology;fetal;fly;Fragile X Syndrome;Gene Expression;Gene Mutation;Gene Proteins;Genes;Genetic;Genetic Transcription;Genomics;Goals;grasp;histone demethylase;Histone H3;Homeostasis;Homologous Gene;House mice;Human;human induced pluripotent stem cells;improved;In Vitro;in vitro testing;in vivo;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Inherited;innovation;innovative technologies;insight;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Interdisciplinary Study;Jordan;Knockout Mice;Knowledge;Lead;Link;loss of function mutation;Lysine;Massive Parallel Sequencing;Mediating;Methylation;model organism;Modeling;Molecular;Morphology;mouse model;multiple omics;Mus;Mutation;mutation correction;Neurodevelopmental Disorder;Neurologic;Neurologic Deficit;neuronal circuitry;Neurons;novel therapeutics;Organoids;Pathologic;Patients;pharmacologic;Phenotype;Play;Process;programs;Proteins;Publications;Publishing;Quality of life;recruit;Regulation;Research;Research Project Grants;Ribosomal Proteins;ribosome profiling;Role;single-cell RNA sequencing;Source;System;Techniques;Testing;tool;Transcript;transcriptomics;Translational Regulation;Translations;Work

PROJECT_TITLE: MOLECULAR MECHANISMS UNDERLYING INTELLECTUAL DISABILITY CAUSED BY MUTATIONS IN THE CHROMATIN MODIFIER KDM5C


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Lymphatic Research;Neurosciences

ORG_CITY: ITHACA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE Lymphatic dysfunction is closely related to major human diseases, including lymphedema, glaucoma, immune dysfunction, cancer, metabolic disease, and neurodegenerative disease. This project will decipher regulation of lymphatic endothelial cell junction and drainage, focusing on ROCK1/2 and integrin α5 signals by using a bioengineered 3D lymphatic vascular system in vitro and mouse inflammation and lymphedema models in vivo.

PI_NAMEs: LEE, ESAK  (contact)

PROJECT_TERMS: 3-Dimensional;Alzheimer's Disease;Animal Model;Architecture;Arthritis;Binding;Biological;Biology;Biomedical Engineering;Biophysics;Blood Vessels;Boston;Brain;Cell Culture Techniques;Cells;Clinical Research;Collaborations;Complex;Development;Dietary Fats;Disease;Drainage procedure;drug candidate;Exhibits;Experimental Models;Fibronectins;Fibrosis;Fluid Balance;Glaucoma;Goals;Homeostasis;Human;human disease;Immune System Diseases;Immunity;Immunologist;In Vitro;in vitro Model;in vivo;in vivo Model;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Intercellular Fluid;Intercellular Junctions;ITGA5 gene;lacteal;Ligands;Liquid substance;Lymph;lymph nodes;Lymphatic;Lymphatic Diseases;lymphatic drainage;lymphatic dysfunction;Lymphatic Endothelial Cells;Lymphatic Endothelium;Lymphatic function;Lymphatic System;lymphatic vessel;Lymphedema;Malignant Neoplasms;Mediating;Meningeal lymphatic system;Metabolic Diseases;Modeling;Morphogenesis;Morphology;Mus;Neurodegenerative Disorders;Neurons;Obesity;Organ;Outcome;Pediatric Hospitals;Pericytes;Permeability;Physiological;Protein Kinase;Regulation;Research Personnel;rho;ROCK1 gene;Role;screening;Signal Transduction;Small Intestines;Structure;therapeutic evaluation;three-dimensional modeling;Tissues;tool;Treatment Efficacy;two-dimensional;Universities;uptake;Vascular System;wasting

PROJECT_TITLE: Regulation of Lymphatic Endothelial Cell Junction and Drainage


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Brain Disorders;Childhood Injury;Clinical Research;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Unintentional Childhood Injury

ORG_CITY: LEXINGTON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Preterm infants (~0.4 million born in the US yearly) are at risk for frequent blood oxygen drops (Intermittent Hypoxemia (IH)) that are linked to multiple short- and long-term neonatal morbidities leading to both lifelong impairments and increased burden on health care cost. Our study investigates both markers and mechanisms of brain injury from increased intermittent hypoxemia in preterm infants. These data will contribute to our understanding of brain injury from intermittent hypoxemia and identify potential targets for developing treatments in the future to improve IH and associated impairments.

PI_NAMEs: ABU JAWDEH, ELIE G (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Adult;Animal Model;Apnea;Axon;Basic Science;Biological Markers;biomarker identification;Blood;Blood - brain barrier anatomy;blood-brain barrier crossing;blood-brain barrier function;brain cell;Brain Injuries;Caffeine;care costs;Caring;Cell Culture System;Cell Culture Techniques;Cell Death;cell injury;Cells;Central Nervous System;Cessation of life;Clinical;clinical biomarkers;Clinical Investigator;Clinical Sciences;cohort;comparison control;Complement;Data;Development;Development Plans;Disease;Doctor of Medicine;Doctor of Philosophy;Drops;early detection biomarkers;Early identification;efficacious treatment;Enzyme-Linked Immunosorbent Assay;Event;Exclusion;experimental study;extreme prematurity;Frequencies;Future;Generations;Goals;Health Care Costs;Hypoxemia;Impairment;improved;In Vitro;Incubated;indexing;Infant;Inflammation;Inflammatory;inhibitor;Injury;Intervention;Knowledge;laboratory experience;Lead;Learning;Ligands;Link;Lung Diseases;Measures;Mediator;Mentors;Mentorship;Methods;Monitor;Morbidity - disease rate;Neonatal Intensive Care;Neonatal Intensive Care Units;neonatal morbidity;neonatal outcome;neonatal respiration;Nervous System Trauma;neurobehavior;Neurodevelopmental Impairment;Neurofilament-L;Neurological outcome;Neurological status;Newborn Infant;Nurses;oligodendrocyte progenitor;Oligodendroglia;Outcome;outcome prediction;Oxygen;Pathway interactions;Patients;Pattern;Plasma;premature;Premature Birth;Premature Infant;Process;prognostication;prospective;Protein Fragment;Proteomics;Published Comment;pulmonary function;Quality of life;receptor;Research;respiratory;Risk;Role;Science;Scientist;Severities;skills training;societal costs;Statistical Models;stem cells;Structure;Supplementation;synergism;systemic inflammatory response;Techniques;Testing;therapy development;Time;Titrations;TLR2 gene;tool;Training;Translational Research;translational scientist;Treatment Effectiveness;treatment strategy;Urine;Ventilator;white matter injury;Work

PROJECT_TITLE: Systemic Mediators and Biomarkers of Injury in Preterm Infants with Intermittent Hypoxemia

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Brain Disorders;Cancer;Clinical Research;Genetics;Immunotherapy;Infectious Diseases;Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Brain metastases affect a significant number of cancer patients and are associated with poor survival. This proposal focuses on the biology of CD8+ T cells, which are a subset of immune cells that directly kill tumor cells and are the target of immunotherapy agents used in the treatment of cancer. Here we will study ways to improve the efficacy of immunotherapy in the treatment of brain metastases.

PI_NAMEs: SUDMEIER, LISA  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Affect;Antigens;Biology;Brain;Cancer Patient;cancer therapy;CD8-Positive T-Lymphocytes;cell killing;Cells;Cephalic;Characteristics;chronic infection;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;CTLA4 gene;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;cytotoxicity;Data;Development;differential expression;Disease Progression;disorder control;Effector Cell;effector T cell;exhaust;exhaustion;Exhibits;Exposure to;Failure;Gene Expression;Gene Expression Profile;gene function;Genes;Genetic Transcription;Goals;Grant;Heterogeneity;Human;Immune;immune cell infiltrate;immune checkpoint blockade;Immunohistochemistry;Immunotherapeutic agent;Immunotherapy;Impairment;improved;Infection;Infiltration;Intracranial Neoplasms;Laboratories;Lymphocyte;Lymphocytic choriomeningitis virus;Mediating;Metastatic malignant neoplasm to brain;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;neoantigens;Neoplasm Metastasis;neoplastic cell;novel;novel strategies;novel therapeutic intervention;Pathway interactions;PD-1 blockade;PD-1 pathway;peripheral blood;Phenotype;Population;Population Heterogeneity;Prevalence;prevent;Process;prognostic significance;programmed cell death protein 1;programs;receptor;recruit;Refractory;Research;Resistance;response;Solid Neoplasm;stem cell differentiation;System;T cell infiltration;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;Tissue-Specific Gene Expression;Tissues;Toxic effect;transcriptomics;Treatment Efficacy;treatment response;tumor;Tumor Antigens;tumor microenvironment;Tumor Promotion;Tumor-infiltrating immune cells;Viral;Viral Antigens;Virus Diseases;Work

PROJECT_TITLE: Characterization of brain metastasis-specific CD8+ T cells

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: DA

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: ATHENS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: OVERALL CENTER: Project Narrative The proposed P50 application is designed to transform scientific understanding regarding the causes and prevention of addictive behaviors by investigating neuroimmune mechanisms that, in concert with family and contextual factors, affect risk for drug use and abuse. Findings will have far-reaching implications for research, practice, and prevention of drug use in communities across the nation.

PI_NAMEs: BEACH, STEVEN R (contact)

PROGRAM_OFFICER_NAME: GOLDSTEIN, AMY B

PROJECT_TERMS: Addictive Behavior;Adolescence;Affect;African American;African American population;Behavior;Behavioral;Biological;Buffers;cardiometabolic risk;career;caregiving;Centers of Research Excellence;Childhood;Chronic;Chronic stress;Communities;Consultations;Consumption;contextual factors;Data;data integration;data-driven model;design;Development;Discipline;Drug abuse;drug abuse prevention;Drug usage;drug use vulnerability;Eating;Economics;Education;emotion regulation;Emotions;ethnic minority;Etiology;evidence base;experience;Exposure to;Family;Fatty acid glycerol esters;Food;Fostering;Funding;Generations;Genetic Complementation Test;health disparity;image processing;imaging facilities;Immune;Immunology;Inflammation;Infrastructure;innovation;Intervention;Investigation;Low income;member;Mentors;minority communities;Modeling;National Institute of Drug Abuse;network models;neural circuit;Neurobiology;Neurocognitive;Neuroimmune;Neuroimmunomodulation;Neurosciences;next generation;Participant;Peripheral;Persons;Physiological;Pilot Projects;Population;Poverty;Prevention;prevention evaluation;Prevention program;Preventive;Process;programs;Provider;Regulation;Research;Research Personnel;Research Project Grants;Research Support;resilience;Resource-limited setting;Resources;Risk;Science;Scientist;Skin;social adversity;social influence;Specific qualifier value;Stress;sugar;supportive environment;System;Testing;theories;tool;Training;Underrepresented Populations;United States National Institutes of Health;Work;Youth

PROJECT_TITLE: Neuroscience, Immunology, Social Adversity and the Roots of Addictive Behaviors: Toward a New Framework for Drug Use Etiology and Prevention


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

PI_NAMEs: BRODY, GENE H. (contact)

PROJECT_TERMS: Addictive Behavior;Administrative Efficiency;adolescent drug use;Affect;African American;African American population;Applications Grants;Attenuated;Basic Science;Behavioral;Biological;Biological Assay;Biological Process;Budgets;Cardiometabolic Disease;cardiometabolism;career;Chronic;Chronic stress;Collaborations;Collection;Communication;Communities;Data;design;Development;Discipline;drug abuse prevention;drug abuse vulnerability;drug resource;Drug usage;Ensure;ethnic minority population;Etiology;experience;Exposure to;Fostering;Funding;General Population;Generations;Grant;Health;Immunologics;Immunology;Inflammatory;Influentials;Infrastructure;innovation;Institution;inter-institutional;interest;Investigation;Laboratories;Mentors;Modeling;network models;neural;Neurobiology;Neurocognitive;Neuroimmune;Neurosciences;next generation;novel;operation;outreach;outreach program;Participant;Peer Review;Persons;Pilot Projects;Population;Poverty;Predisposition;Prevention;Prevention Research;Preventive;preventive intervention;Procedures;Process;Productivity;programs;Protocols documentation;Provider;Publishing;Research;Research Personnel;Research Project Grants;Research Support;resilience;resilience factor;Resource Sharing;Resource-limited setting;Resources;Risk;Science;Scientist;Signal Transduction;social adversity;Specialized Center;Structure;synergism;System;Testing;Training;United States National Institutes of Health;Universities;working group

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: DISENTANGLING SUGAR SIGNALING IN PLANTS PROJECT NARRATIVE  This project will provide insights into how sugar signaling controls plant growth. Since the genes that will be studied here are conserved across all living organisms, understanding the mechanisms that allow sugars to control cell size and proliferation could lead to better treatments for human diseases characterized by the dysregulation of sugar metabolism (such as diabetes, obesity, and even cancer) and allow more sophisticated manipulations of microorganisms for the bioeconomy.

PI_NAMEs: CHEUNG, LILY S (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Affect;Anatomy;Biological Models;Cell Proliferation;Cell Size;Cells;Cellular Metabolic Process;Chemicals;Confocal Microscopy;Development;Diabetes Mellitus;Enzymes;Fructose;Gene Expression;Genes;Glucose;Goals;human disease;Individual;insight;Malignant Neoplasms;Metabolic;Metabolism;Methods;microorganism;Monitor;Mouse-ear Cress;Mutation;Obesity;Organ;Organism;Phenotype;Physiological;plant growth/development;Plants;pleiotropism;Protein Engineering;Regulation;Resolution;Role;screening;Signal Transduction;sugar;synthetic biology;synthetic construct;Tissues;tool

PROJECT_TITLE: Disentangling Sugar Signaling in Plants

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

PI_NAMEs: MILLER, GREGORY E. (contact)

PROJECT_TERMS: Acceleration;Addictive Behavior;Affect;Affective;African American;African American population;Behavior;Biological Assay;Biological Markers;Biometry;Brain;Capital;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Centers of Research Excellence;Chronic stress;Cognitive;Collaborations;Communities;Consultations;Consumption;contextual factors;Data;data analysis pipeline;Data Analytics;data exchange;data management;design;Development;Drug abuse;Drug usage;drug use vulnerability;Education;Educational workshop;emotion regulation;ethnic minority;Etiology;experience;Exposure to;Family;Fatty acid glycerol esters;Food;Functional Magnetic Resonance Imaging;Funding;Generations;Goals;Health;imaging facilities;Immune signaling;Immunology;Inflammation;Inflammatory;inflammatory marker;Intervention;Investigation;Low income;member;minority communities;Mission;Motivation;National Institute of Drug Abuse;network models;neural circuit;Neurobiology;Neurocognitive;neuroimaging;Neuroimmune;Neurosciences;next generation;Participant;Peripheral;Persons;Physiological;Pilot Projects;Population;prevent;Prevention;Preventive;Process;Productivity;programs;protocol development;Protocols documentation;psychosocial;Research;Research Personnel;Research Project Grants;Research Support;resilience;resilience factor;Resource-limited setting;Resources;Risk;Risk Factors;Sampling;Science;Scientist;Services;Skin;social adversity;social influence;Specific qualifier value;Specimen;Stress;Structure;substance misuse;substance misuse prevention;substance use;sugar;symposium;System;Targeted Research;Testing;therapy development;Training and Education;Universities;working group;Youth

PROJECT_TITLE: Research Support Core


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

PI_NAMEs: KOGAN, STEVEN M (contact)

PROJECT_TERMS: Acceleration;Addictive Behavior;Address;Adolescence;Adolescent;Affect;African American;African American population;Age;age group;Applications Grants;Area;Attenuated;Award;Behavioral;Biological Process;Brain;Cardiometabolic Disease;cardiometabolism;career;career development;Center Core Grants;Centers of Research Excellence;Childhood;Chronic stress;cohort;contextual factors;Data;Data Analyses;Data Set;design;Development;Diet Habits;drug abuse prevention;drug development;Drug usage;Eating;Etiology;experience;Exposure to;Faculty;Family;Feedback;Fostering;Foundations;Functional Magnetic Resonance Imaging;Funding;Funding Mechanisms;Future;Generations;Goals;Grant;Health;Immune;Immunology;Individual;Inflammation;Inflammation Mediators;innovation;insight;Institution;interdisciplinary collaboration;Investigation;Learning;Mediator;Mentors;Mentorship;Methodology;Minority;Modeling;Monitor;network models;neural;Neurobiology;Neuroimmune;Neurosciences;next generation;novel;novel strategies;Observational Study;Peer Review;Persons;Pilot Projects;Population;Poverty;Prevention;Prevention program;Prevention trial;Preventive;Process;programs;psychosocial;Publications;racial discrimination;Randomized;randomized trial;Recording of previous events;recruit;Research;Research Personnel;research study;Research Training;resilience;resilience factor;Resource-limited setting;Resources;Risk;Risk Factors;Role;Sample Size;Science;Scientific Advances and Accomplishments;Scientist;secondary analysis;social adversity;substance use;substance use prevention;success;System;Training;transmission process;Underrepresented Populations;Universities;Work;working group;young adult

PROJECT_TITLE: Pilot Innovation Core


NIH_SPENDING_CATS: Nutrition

ORG_CITY: SAINT LOUIS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative:  Relevance to public health: Zinc is an essential nutrient that is critical for human health, since zinc deficiency and excess both cause a wide range of health problems. This research will determine how animals protect themselves against excess zinc by storing zinc in lysosomes, and how lysosomes are remodeled to accommodate zinc storage. These studies address novel aspects of the basic biology of lysosomes, which may be informative for lysosomal storage diseases in humans. Insights into mechanisms of zinc homeostasis may suggest new strategies for treating diseases caused by abnormal zinc metabolism.

PI_NAMEs: KORNFELD, KERRY  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Address;Affect;Animals;Binding;Biogenesis;Biological;Biological Models;Biology;Caenorhabditis elegans;Cell Culture Techniques;Cell Nucleus;Cells;cofactor;Contracts;Data;dietary manipulation;Dietary Zinc;Disease;Drug Metabolic Detoxication;experimental study;Family;flexibility;Fluorescence Microscopy;forward genetics;Genes;Genetic;Genetic Transcription;Goals;Health;Homeostasis;Human;innovation;insight;Intestines;Kinetics;Laboratories;lysosomal proteins;Lysosomal Storage Diseases;lysosome membrane;Lysosomes;macromolecule;Mammalian Cell;Mammals;Mediating;Medical Research;Membrane;Messenger RNA;Metabolism;Methods;Microscopy;Modeling;Molecular;Monitor;Nature;novel;novel therapeutic intervention;Nutrient;Organelles;Pathway interactions;Pattern;Play;Population;Process;Proteins;Proteome;Public Health;Reagent;Regulation;Research;Resistance;response;Roentgen Rays;Role;Site;Structure;superresolution microscopy;Surface;Techniques;Testing;Time;transcription factor;Zinc;Zinc deficiency;zinc-binding protein;ZIP protein

PROJECT_TITLE: Lysosome remodeling mediates high zinc homeostasis

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it evaluates the association of cerebrovascular pressure reactivity (CVPR) impairments and autonomic nervous system (ANS) dysfunction in long-term physical and cognitive disability after moderate to severe traumatic brain injury (TBI). CVPR impairments and ANS dysfunction are two understudied sequelae of moderate to severe TBI that may play an important pathophysiologic role in long-term deficits after moderate to severe TBI. The proposed study is relevant to the National Institute of Neurological Disorders and Stroke (NINDS) stated mission to “seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease for all people.”

PI_NAMEs: PINTO, SHANTI MARIE (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Acute;Adult;Age;Amnesia;Attenuated;Autonomic Dysfunction;Autonomic nervous system;Blood Pressure;Blood Pressure Monitors;Brain;cerebrovascular;Cerebrovascular Circulation;Chronic Phase;Clinical;Cognition;Cognitive;cognitive disability;cognitive recovery;cohort;Data;Enrollment;Equilibrium;follow-up;Frequencies;Functional disorder;functional outcomes;Future;Glasgow Coma Scale;Glasgow Outcome Scale;Goals;Heart Diseases;Heart Rate;heart rate variability;Hospital Mortality;Hour;Impairment;indexing;Individual;Injury;innovation;Inpatients;Intracranial Pressure;Knowledge;Long term physical disability;Measurement;Measures;Mediating;Mission;Monitor;mortality risk;Muscle;National Institute of Neurological Disorders and Stroke;Nerve;Nervous System;Nervous System control;Nervous System Disorder;Nervous System Physiology;Outcome;Parasympathetic Nervous System;Patient Admission;Persons;Play;pressure;prevent;Process;Prognostic Marker;prognostication;Public Health;Recording of previous events;Recovery;Recovery of Function;Rehabilitation therapy;Research;Role;sex;Sympathetic Nervous System;Telephone;Temperature;Testing;Time;Transcranial Doppler Ultrasonography;Traumatic Brain Injury;Treatment Protocols;Unconscious State;vasoconstriction

PROJECT_TITLE: Sympathetic Activation and Cerebrovascular Pressure Reactivity after Traumatic Brain Injury (TBI)

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Nutrition;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

PI_NAMEs: NUSSLOCK, ROBIN  (contact)

PROJECT_TERMS: addiction;Addictive Behavior;Address;Adolescence;Affect;African American;African American population;Age;Amygdaloid structure;Attenuated;Behavior;Behavioral;biobehavior;Biological;Biology;Blood;Body System;Brain;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Childhood;Chronic;Chronic stress;Communities;Consensus;Consumption;Corpus striatum structure;Data;design;Development;Diet;Diet Habits;Disparity;Drug abuse;drug abuse prevention;Drug usage;drug use vulnerability;Eating;Eating Behavior;emerging adult;emotion regulation;Emotions;Enrollment;Etiology;executive function;Exposure to;Fatty acid glycerol esters;Food;Functional disorder;functional MRI scan;Funding;Generations;Health;health disparity;High Fat Diet;Immune system;Immunology;Individual;Inflammation;Investigation;Link;Low income;Modeling;National Institute of Drug Abuse;negative affect;network models;neural;neural circuit;Neurobiology;Neuroimmune;Neuroimmunomodulation;neuroregulation;Neurosciences;neurotransmission;next generation;Outcome;Participant;Pathway interactions;Peripheral;Persons;Phenotype;Physiological;Population;Poverty;Prevention;Prevention program;Preventive;preventive intervention;primary caregiver;Process;programs;prospective;Prospective Studies;Public Health;public health relevance;Regulation;Research;Research Project Grants;Research Support;resilience;Resource-limited setting;reward circuitry;reward processing;Rewards;Risk;Sampling;Science;Scientist;Signal Transduction;Skin;social adversity;social influence;Specific qualifier value;Stress;stressor;Structure;substance misuse;substance use;sugar;System;Testing;theories;Time;transition to adulthood;Universities;Work;Youth

PROJECT_TITLE: Research Project 1: Neuroimmune Mechanisms, Addictive Behaviors, and Cardiometabolic Health among African American Emerging Adults: A Prospective Study


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: NARRATIVES: Cardiac energy consumption is the central determinant of cardiac function and its impairment is the hallmark of heart failure (HF). However, there are no clinically available noninvasive approaches to accurately quantify alterations in cardiac energy consumption for surveillance of patients at risk of developing HF or to evaluate the efficacy of novel therapies that are actively under development for HF. This proposal aims to develop a magnetic resonance imaging method that is noninvasive, quantitative, and accurate for estimating cardiac energy consumption, which enables non-invasive surveillance of cardiac energetics and provides a fundamental tool to guide the development of treatments targeting the energy imbalance in the failing hearts.

PI_NAMEs: YANG, HSIN-JUNG  (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: Adopted;Aerobic;Affect;Anatomy;Animal Model;Award;Biological Markers;Blood;Blood flow;blood oxygen level dependent;Breathing;Cardiac;Cardiac health;cardiac magnetic resonance imaging;career;Catheterization;Chronic;Classification;Clinical;clinical practice;Contrast Media;Coronary Arteriosclerosis;Coronary Circulation;Coronary sinus structure;Cyclotrons;Data;Dependence;Development;Diastole;Disease;Disease Surveillance;Dose;Early Diagnosis;Early Intervention;efficacy evaluation;Energy consumption;Energy Metabolism;Family suidae;Flowmetry;Foundations;Functional disorder;Guidelines;Heart;Heart failure;heart function;heart metabolism;heart motion;Heart Rate;high risk;Hospitalization;Image;imaging modality;Impairment;improved outcome;Ionizing radiation;Journals;Magnetic Resonance;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Maps;Measurement;Measures;Mechanics;Mediation;Medical Care Costs;Mental Depression;Methods;Modeling;Monitor;mortality risk;Motion;Movement;Myocardial;Myocardial dysfunction;Myocardial Infarction;Myocardium;Needles;new epidemic;novel;novel therapeutic intervention;novel therapeutics;Outcome;oxidation;Oxygen;Oxygen Consumption;Oxygen saturation measurement;Patients;Persons;pharmacologic;Phase;Physiologic pulse;Play;Population;Positron-Emission Tomography;prevent;Preventive;Preventive treatment;Procedures;Prognosis;Publications;Recommendation;Research Personnel;Resolution;respiratory;Rest;Risk;Role;screening;Secondary to;Site;Societies;Staging;Stress;Systole;targeted treatment;Techniques;Testing;therapy development;Time;tool;Treatment Efficacy;Treatment Failure;Venous;Work

PROJECT_TITLE: Push-Button Cardiac MRI for Non-Invasive Quantification of Myocardial Energy Consumption in Heart Failure

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

PROJECT_TERMS: Addictive Behavior;Address;Adolescence;Adolescent;African American;African American population;Age;Attenuated;Behavior;Behavioral;Biological;biological adaptation to stress;Blood;Brain;cardiometabolic risk;cardiometabolism;Child Rearing;Childhood;Chronic;Chronic stress;Consensus;Corpus striatum structure;Data;Decision Making;design;Disparity;drug abuse prevention;Drug usage;drug use vulnerability;dysphoria;early onset substance use;Eating;emotion regulation;Etiology;executive function;experience;Exposure to;Family;Family Relationship;follow-up;Functional disorder;Functional Magnetic Resonance Imaging;Future;Health;health disparity;Hormones;Immune system;Immunology;indexing;Individual;Inflammation;Inflammatory;Intervention;Investigation;Link;Long-Term Effects;Longterm Follow-up;lower income families;Measures;Mediating;Modeling;network models;neural;neural circuit;Neurobiology;neurochemistry;Neurocognitive;Neuroimmune;Neurosciences;neurotransmission;Outcome;Parents;Participant;Peripheral;Physiological;Play;Population;prevent;Prevention;Prevention program;Prevention trial;Process;programs;psychosocial;Randomized;Randomized, Controlled Trials;Research Project Grants;Research Support;reward circuitry;reward processing;Rewards;Risk;Risk Factors;Risk Marker;Role;Science;Scientist;Series;Signal Transduction;Skin;social adversity;Specific qualifier value;Stress;stressor;Structure;substance misuse;System;Testing;transition to adulthood;Unhealthy Diet;Work;young adult;Youth

PROJECT_TITLE: Research Project 2: Can Family-Centered Prevention Programming Reduce Neuroimmune Vulnerabilities for Drug Use and Health Risk among African American Adolescents?: A Randomized Prevention Trial


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Pediatric;Social Determinants of Health;Substance Misuse

ORG_CITY: RICHMOND

ORG_DEPT: PSYCHIATRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative Unconfounding the impact of parent-to-offspring molecular genetics on SU and SUDs from the parental and home environments is the central task of genetics. We use a highly innovative method to identify not only the molecular pathways to SU and SUDs but also to show how parental gene expression networks ‘genetically nurture’ SU and SUDs by helping to foster risky and protective environments.

PI_NAMEs: GILLESPIE, NATHAN ALEXANDER (contact);VLADIMIROV, VLADIMIR IVANOV

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: Address;alcohol involvement;Alcohols;Behavior;Behavioral;biological sex;brain tissue;Cannabis;Child;Cohort Studies;Complex;Data;Disease;emotion regulation;Environment;Environmental Risk Factor;Etiology;Family;Fostering;Gene Expression;gene interaction;gene network;Genes;Genetic;Genetic Diseases;Genetic Risk;Genetic study;Genome;genome wide association study;genome-wide;Genotype;Heritability;Home environment;Individual;Individual Differences;innovation;Link;Measures;Mediating;Meta-Analysis;Methodology;Methods;Modeling;Molecular;Molecular Genetics;neglect;Nicotine;novel;offspring;parental influence;Parents;Pathway Analysis;Pathway interactions;Peer Group;population based;Research;Risk;Sampling;Socioeconomic Status;Source;substance misuse;substance use;Substance Use Disorder;Techniques;trait;transmission process;Twin Multiple Birth;Twin Studies;Validation

PROJECT_TITLE: Using transmitted and untransmitted gene networks to identify molecular pathways to substance use & misuse in genetically controlled twins

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


PI_NAMEs: EHRLICH, KATHERINE BABCOCK (contact)

PROJECT_TERMS: addiction;Addictive Behavior;Adolescent;Adult;Affect;African American;African American population;Age;Alcohol consumption;Attenuated;Behavior;behavior test;behavioral outcome;Brain;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Caregivers;Centers of Research Excellence;Child;Child Rearing;Chronic;Chronic stress;Collection;Communication;Consumption;contextual factors;Data;design;Development;Diet Habits;Discipline;Drug abuse;drug development;drug misuse;Drug usage;Eating;Economics;emotion regulation;Emotions;Empirical Research;Etiology;executive function;Exposure to;Family;Fatty acid glycerol esters;Food;Funding;Generations;Genetic;Glucose Intolerance;grandparent;Health;Hypertension;Immunology;Individual;Inflammation;insight;Insulin Resistance;intergenerational;Investigation;Link;Lipids;Longitudinal cohort study;Modeling;Monitor;National Institute of Drug Abuse;network models;neural circuit;Neurocognitive;Neuroimmune;Neurosciences;next generation;Nicotine;novel;Obesity;Parents;Pathway interactions;Peripheral;Persons;Pharmaceutical Preparations;Poverty;preadolescence;prevent;Prevention;Prevention program;Preventive;primary endpoint;Process;programs;protective effect;psychosocial outcome;Race;racial discrimination;randomized trial;recruit;Research Project Grants;resilience;Resource-limited setting;reward processing;Risk;Risk Factors;rural African American;Rural Community;Sampling;Science;social adversity;social influence;Socialization;Stress;stressor;substance use prevention;sugar;System;Testing;transmission process;Unemployment;Unhealthy Diet;virtual;Youth

PROJECT_TITLE: Research Project 3: Intergenerational Transmission of Neuroimmune Vulnerabilities for Addictive Behaviors among African American Youth: A Three Generation Study


ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Narrative Promoting psychological and cognitive resilience in response to external stressors is one of the most difficult challenges to mental health. The research proposed in this BDSRC will provide a unique and detailed dissection of the role of dietary polyphenolic botanical supplements in the maintenance and promotion of biological and behavioral resilience in both preclinical animal models and translational human studies of stress- induced psychological impairment. In particular, it will focus on stress-induced maladaptive physiological and immunological responses that occur in the brain and the ability of the polyphenolic supplement to counteract the detrimental consequences of stress that contribute to the pathogenesis of neuropsychiatric disorders such as depression and anxiety.

PI_NAMEs: MURROUGH, JAMES WARREN (contact);RUSSO, SCOTT JAMES

PROGRAM_OFFICER_NAME: STILL, PATRICK COLBY

PROJECT_TERMS: Acids;Address;Affect;Animal Model;Anti-Inflammatory Agents;Anxiety;Behavior;Behavioral;Biological;biological adaptation to stress;Biological Availability;Biological Models;Biometry;Blood - brain barrier anatomy;blood-brain barrier permeabilization;Botanical dietary supplements;Botanicals;Brain;Cells;Chronic stress;Clinical;clinical development;clinical investigation;Clinical Pharmacology;Clinical Trials;Clinical Trials Design;Cognitive;Complement;cytokine;Data;data management;depression model;depressive symptoms;design;dietary;Dietary Polyphenol;Dissection;Drug Kinetics;Endothelial Cells;Event;Feasibility Studies;Functional disorder;Future;Grant;Human;human tissue;Imaging Techniques;Immune;immune cell infiltrate;immune function;Immune response;Immunosuppression;Impairment;in vivo;Inflammatory;Infrastructure;insight;Interdisciplinary Study;Interleukin-6;Interneuron function;Interneurons;Investigation;Leukocytes;Maintenance;Mental Depression;Mental Health;Microglia;Modeling;Mus;Neurons;neuropsychiatric disorder;Nucleus Accumbens;Pathogenesis;Pathway interactions;Peripheral;Phenotype;Physiological;Plasma;polyphenol;pre-clinical;preclinical study;Predisposition;Preparation;prevent;Production;programs;promote resilience;Property;Protocols documentation;psychologic;Psychological Stress;quality assurance;Regulation;Research;Research Design;Research Project Grants;resilience;resilience biomarker;Resources;response;Risk;Rodent;Role;Stress;stress related disorder;Stress Tests;stressor;Supplementation;Synapses;Synaptic plasticity;synergism;System;Testing;Tissue Sample;Tissues;transcriptome sequencing;Trier Social Stress Test;Up-Regulation;Validation

PROJECT_TITLE: Influence of Dietary Botanical Supplements on Biological and Behavioral Resilience


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Complementary and Integrative Health;Depression;Dietary Supplements;Genetics;Immunotherapy;Mental Health;Natural Products;Neurosciences;Nutrition;Prevention

PI_NAMEs: RUSSO, SCOTT JAMES (contact)

PROJECT_TERMS: Acids;Address;Affect;Affinity Chromatography;Behavior;Behavioral;Biological;Biological Availability;Biological Models;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier function;blood-brain barrier permeabilization;Botanical dietary supplements;Brain;Brain region;Cells;Cerebral endothelium;Clinical;Clinical Trials;Complex;cytokine;Cytokine Gene;Depressed mood;depression model;depressive behavior;Dietary Polyphenol;Diffusion;Dyes;Endothelial Cells;endothelial dysfunction;Event;Excitatory Synapse;Exposure to;Functional disorder;Future;Gene Expression;Gene Expression Profile;Generations;Genes;Genetic;Glutamates;Goals;Homeostasis;Immune;immune cell infiltrate;immune function;Immune response;Immunologic Factors;immunoregulation;Immunosuppression;Impairment;Infiltration;Inflammasome;Inflammatory;Interleukin 6 Receptor;Interleukin-1 beta;Interleukin-6;Knock-in;Leukocytes;Maintenance;Major Depressive Disorder;Mental Depression;Methods;Microglia;Modeling;Molecular;Molecular Target;monocyte;Morphology;Mus;neural;Neurons;Neurophysiology - biologic function;neurovascular injury;Nucleus Accumbens;Patients;Peripheral;Physiological;Plasma;polyphenol;Predisposition;Preparation;prevent;Production;promote resilience;Proteins;psychologic;receptor;Receptor Gene;Regulation;resilience;resilient behavior;response;Ribosomes;social;social stress;Stimulus;Stress;Structure;Supplementation;symptomatology;Synapses;synaptogenesis;synergism;Techniques;transcriptome;transcriptome sequencing;Translating;translating ribosome affinity purification and RNA-sequencing;Up-Regulation;Work

PROJECT_TITLE: Suppression of Immune Signatures of Stress by Polyphenols Supplements


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Dietary Supplements;Major Depressive Disorder;Mental Health;Mental Illness;Natural Products;Neurosciences;Nutrition;Prevention

PI_NAMEs: MURROUGH, JAMES WARREN (contact)

PROJECT_TERMS: Acids;Acute;acute stress;Address;Animals;Anti-Inflammatory Agents;Anxiety;Behavior;Behavioral;Biological;Biological Availability;Biological Models;Blood;Botanical dietary supplements;Botanicals;burden of illness;Central Nervous System;Clinical;Clinical Pharmacology;Clinical Trials;cytokine;depressive symptoms;dietary;Dietary Polyphenol;Dose;Double-Blind Method;Drug Kinetics;Eligibility Determination;Exhibits;experimental study;Functional disorder;Future;gastrointestinal;gastrointestinal bacteria;grape seed;Grapes;Health;healthy volunteer;Human;IL-6 inhibitor;Immune;Impairment;Individual;Inflammation Mediators;Inflammatory;inflammatory marker;Interleukin-6;Intervention;Juice;Knowledge;Laboratories;Lead;Leukocytes;Link;Literature;Major Depressive Disorder;Mental Depression;Mental disorders;Mental Health;Modeling;opportunity cost;Oral;Oral Administration;Outcome;Pathologic;patient subsets;Patients;Peripheral;Pharmacodynamics;Phenotype;Placebo Control;Placebos;Plants;Plasma;polyphenol;pre-clinical;Predisposition;Preparation;prevent;Production;promote resilience;Property;psychologic;Psychological Models;Psychological Stress;Randomized;Refractory;Regulation;research clinical testing;Research Design;Research Project Grants;resilience;response;Risk Factors;Rodent;Safety;Signal Transduction;Statistical Methods;Stress;stress related disorder;Supplementation;Synaptic plasticity;Testing;therapeutic target;Therapeutic Uses;trans-resveratrol;translational potential;treatment duration;treatment-resistant depression;Trier Social Stress Test;Up-Regulation;Validation;Work;Xenobiotic Metabolism

PROJECT_TITLE: Clinical Pharmacology and Target Validation of BDPP for Stress-Related Disorders


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE Target-directed microRNA degradation (TDMD) is a mechanism by which endogenous target RNAs degrade specific microRNAs to modulate gene expression. Treatment of T-cell acute lymphoblastic leukemia (T-ALL) cells by glucocorticoid induces apoptosis through BIM expression, which can lead to microRNA-221/222 degradation via TDMD. We will examine how microRNA-221/222 degradation may contribute to T-ALL apoptosis, globally profile TDMD events and explore the role of TDMD during glucocorticoid-treatment of T-ALL.

PI_NAMEs: LICHT, JONATHAN D.;XIE, MINGYI  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Acute Lymphocytic Leukemia;Acute T Cell Leukemia;acute T-cell lymphoblastic leukemia cell;Adenosine;Affect;aged;Apoptosis;Apoptotic;Base Pairing;Binding;Biochemical;bioinformatics pipeline;Biology;cancer cell;cancer diagnosis;Cancer Intervention;cancer therapy;Cell Death;Cell Line;Cell Membrane Permeability;Cells;chemotherapy;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Collecting Cell;combat;CRISPR screen;CRISPR/Cas technology;crosslink;Data Set;Degradation Pathway;Development;Dexamethasone;differential expression;DNA;Elements;Enzymes;Event;gene discovery;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;genetic information;Genetic Transcription;genome-wide;Glucocorticoid-induced apoptosis;Glucocorticoids;Hematopoietic Neoplasms;Hybrids;improved;Induction of Apoptosis;innovation;leukemia;Leukemia Acute Lymphoblastic Chemotherapy;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;Mediating;Messenger RNA;MicroRNAs;mitochondrial membrane;Mixed B- and T-Cell Leukemia;Molecular;Mus;mutant;Mutate;Mutation;Mutation Analysis;Names;novel;novel therapeutics;Nucleotides;Oncogene Activation;Oncogenic;Pathologic;Pathway Analysis;Pathway interactions;patient derived xenograft model;Patients;Persons;Physiological;prevent;pro-apoptotic protein;Process;Proteins;Protocols documentation;Regulation;Repression;Resistance;resistance mechanism;response;RNA;Role;Sampling;Sequence Analysis;Small RNA;standard care;Steroids;System;Tail;Therapeutic Intervention;therapeutic RNA;Transcript;transcriptome sequencing;Translating;Translations;Tumor Suppressor Proteins;ubiquitin ligase;Untranslated Regions;Untranslated RNA;Uridine;Validation;Xenograft Model

PROJECT_TITLE: Exploring microRNA degradation in T-cell acute lymphoblastic leukemia

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Microbiome;Networking and Information Technology R&D (NITRD);Nutrition

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative This project seeks to provide a platform for the discovery of causal health effects of the human gut microbiome. For this, it provides exploration tools and inference techniques that unlock the potential of a recently acquired, vast data set comprising >10,000 stool samples, >1.5 million medical records, and >400,000 blood measurements from cancer patients. This enables discovery of candidate microbes that affect pharmacokinetics of human-targeted drugs, and reveals natural competitor species to common pathogens, thus revealing targets for rational microbiome engineering, towards turning the human gut microbiome into a therapeutic target of the future.

PI_NAMEs: SCHLUTER, JONAS  (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;Affect;Algorithms;Artificial Intelligence;Bayesian Analysis;Biological;Blood;Blood Chemical Analysis;Blood specimen;Cancer Patient;Categories;Cells;Cohort Studies;commensal microbes;Complex;complex data;cost;Data;Data Set;Data Sources;data visualization;Decision Making;Diet;Diet Records;Disease;Drug Kinetics;Drug Targeting;Ecology;Ecosystem;Engineering;Etiology;Event;Exclusion;experience;experimental study;Food;Frequencies;Future;gut microbiome;gut microbiota;Gut Mucosa;Health;Hematopoietic Stem Cell Transplantation;high dimensionality;Human;Human body;Immune;Immune system;Immunomodulators;Immunophenotyping;immunoregulation;in silico;In Situ;In Vitro;Infection;large datasets;Leukocytes;Machine Learning;Measurement;Medical Records;Metadata;Metagenomics;Methods;Microbe;microbial;microbiome;microbiota composition;multidimensional data;next generation;novel;Nutritional;Online Systems;pathogen;Patients;Pharmaceutical Preparations;phenotypic data;Physiological;Physiology;Publishing;Records;Research;Resolution;Resources;Ruminococcus;Sampling;Scanning;Shotguns;stool sample;Stream;Structure;structured data;success;Tacrolimus;Taxonomy;Techniques;Testing;Therapeutic;therapeutic target;Time;tool;Trees;unsupervised learning;Visualization;web based interface

PROJECT_TITLE: The unleashed microbiome of cancer patients as a discovery platform for rational microbiome engineering


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Complementary and Integrative Health;Dietary Supplements;Natural Products;Nutrition;Prevention

PI_NAMEs: SIMON, JAMES E (contact)

PROJECT_TERMS: Acceleration;Accounting;Adopted;Animals;Anthocyanins;Archives;Area;Behavioral;Biological;Biological Availability;Biometry;Blood;Botanical dietary supplements;Botanicals;brain tissue;Catechin;Chromatography;Clinical Pharmacology;Clinical Trials;Cognition;Cognitive;Communication;Coupled;design;Dietary Polyphenol;Dietary Supplementation;Drug or chemical Tissue Distribution;Ensure;epicatechin;experimental study;Flavonoids;Flavonols;Fostering;Goals;grape seed;Grapes;Human;Human Resources;Immunosuppression;in vivo;Individual;Industrialization;Juice;Leadership;Life;Liquid Chromatography;Liquid substance;Mass Chromatography;Mass Spectrum Analysis;metabolic abnormality assessment;Methods;Methylation;Mus;National Center for Complementary and Integrative Health;Nature;novel;Nuclear Magnetic Resonance;nuclear Overhauser enhancement;Parents;Phase;phenolic acid;Plasma;polyphenol;preservation;Procedures;Protocols documentation;psychologic;quality assurance;Quality Control;quantum;Quercetin;repository;Research;Research Personnel;Research Project Grants;resilience;Resolution;Resveratrol;sample archive;Sampling;screening;Spectrum Analysis;stability testing;Stilbenes;Stress;stress related disorder;System;tandem mass spectrometry;Techniques;Testing;Tissues;Validation;Work

PROJECT_TITLE: Botanical Core


NIH_SPENDING_CATS: Aging;Complementary and Integrative Health;Dietary Supplements;Natural Products;Nutrition

PROJECT_TERMS: Advisory Committees;Agreement;Behavioral;Biological;Biometry;Botanical dietary supplements;Categories;Collaborations;Communication;Data;Data Analyses;data integration;data management;Data Management Resources;Data Set;data sharing;Data Storage and Retrieval;data warehouse;design;Development;Dietary Polyphenol;Fostering;Funding;Future;Goals;Human Resources;Impairment;Institution;Leadership;medical schools;Monitor;operation;outreach;promote resilience;psychologic;Research;Research Personnel;Research Project Grants;resilience;scientific computing;social stress;Statistical Data Interpretation;Structure;success;System;Testing;Time;Vision;web interface;working group

PROJECT_TITLE: Administrative, Biostatistics, and Management Core


NIH_SPENDING_CATS: Asthma;Health Effects of Indoor Air Pollution;Lung

ORG_CITY: LA JOLLA

ORG_NAME: LA JOLLA INSTITUTE FOR IMMUNOLOGY

PHR: PROJECT NARRATIVE WHO estimated that 20% of the world’s population suffer from respiratory allergies and derived diseases such as allergic rhinitis and asthma. However, there is still no clear answer to the question: “why do only some people develop allergy?”, underscoring the need to revisit our understanding of immune mechanisms of allergy. Using novel genomics unbiased tools, we discovered a new type of T cells, we called THIFNR cells, that, complementary to Tregulatory cells, may play an important role in preventing pathogenic inflammation in allergy and asthma. This grant aims to advance our understanding of the role of this novel subset in controlling allergic immune responses. Our work will provide novel mechanistic insights that may lead to the development of better therapeutic options for patients with allergic diseases.

PI_NAMEs: SEUMOIS, GREGORY  (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: 2019-nCoV;Address;airway inflammation;Allergens;Allergic;Allergic Disease;Allergic inflammation;allergic response;Allergic rhinitis;Asthma;asthmatic;asthmatic patient;Automobile Driving;Blood specimen;Brain;CD4 Positive T Lymphocytes;Cell Death;Cell Separation;Cells;Circulation;Clinic;Coculture Techniques;Code;cohort;Complement;COVID-19 patient;cytokine;Development;Disease;dust mite allergy;experimental study;Exploratory/Developmental Grant;Exposure to;Extrinsic asthma;flu;Follow-Up Studies;Frequencies;fungus;Future;genetic signature;Genomics;Grant;Health;Heterogeneity;House Dust Mite Allergens;Human;Hypersensitivity;Immune;Immune response;Immunology;In Vitro;in vivo;Individual;Inflammation;Influenza;insight;Interferon-beta;Interferons;Ligands;Lung;Mediating;memory CD4 T lymphocyte;novel;Pathogenicity;Patients;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Play;Population;prevent;Process;Production;Proliferating;Property;Proteins;Pyroglyphidae;receptor;Regulatory T-Lymphocyte;Research;respiratory;respiratory virus;response;Role;Sampling;Science;Surface;T cell receptor repertoire sequencing;T-Cell Activation;T-cell diversity;T-cell receptor repertoire;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Th1 Cells;Th2 Cells;Therapeutic;Tissue Sample;TNF-related apoptosis-inducing ligand;TNFSF10 gene;tool;transcriptome;Translating;Viral;Visit;Work

PROJECT_TITLE: A novel CD4+ T cell subset associated with allergy protection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDB-K(57)]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: Project Narrative There are currently no curative therapies for glioblastoma (GBM), which is almost universally fatal. Cells within these tumors are governed by the same molecular forces that shape the developing brain, but instead of maturing into adult cell types are stalled indefinitely at progenitor stages. This project asks where and why GBM cells are stuck in their developmental trajectories and attempts to exploit the molecules that normally drive terminal astrocyte differentiation during development in the hopes of maturing, and thus slowing, GBM tumors.

PI_NAMEs: SLOAN, STEVEN A (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Adult;Affect;Astrocytes;ATAC-seq;Attenuated;Automobile Driving;Biological;Biological Assay;Biological Models;Brain;candidate identification;cell behavior;cell type;Cells;Characteristics;ChIP-seq;Chromatin;curative treatments;Data;Development;DNA Binding;driver mutation;Educational process of instructing;Engineering;epigenomics;Excision;Exhibits;experimental study;fetal;Fetal Development;Genetic Transcription;Genomics;Glioblastoma;Gliomagenesis;Growth;Heterogeneity;Human;Human Development;human induced pluripotent stem cells;In Vitro;Individual;induced pluripotent stem cell;Knock-out;Literature;Malignant Neoplasms;malignant neurologic neoplasms;Maps;Modeling;Molecular;Mutation;neoplastic cell;Neuroglia;Neurons;novel;Nuclear;Operative Surgical Procedures;Organoids;overexpression;Phagocytosis;Population;postnatal human;Primary Brain Neoplasms;Process;progenitor;programs;Proliferating;Protocols documentation;Scheme;Severity of illness;Shapes;stem cells;System;temporal measurement;Testing;therapy resistant;three dimensional cell culture;transcription factor;transcriptome sequencing;transcriptomics;tumor;Work

PROJECT_TITLE: Shared mechanisms of astrocyte maturation in development and glioblastoma

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Pediatric;Physical Activity;Physical Rehabilitation;Prevention;Rare Diseases;Rehabilitation;Social Determinants of Health;Telehealth

ORG_CITY: KANSAS CITY

ORG_NAME: CHILDREN'S MERCY HOSP (KANSAS CITY, MO)

PHR: PROJECT NARRATIVE Cardiorespiratory fitness [VO2peak] is one of the strongest predictors of cardiac related co-morbidities including physical and psychosocial function, quality of life, heart transplantation, and mortality in those with congenital heart disease [CHD]. The primary aim of the proposed clinical trial is to evaluate the effectiveness of a remotely delivered, in-home, supervised cardiac rehabilitation [CR] exercise program delivered to groups of adolescents with congenital heart disease [n=74] by live health coach via group video conferencing technology; thus eliminating barriers related to accessibility for patients/families who may not have the capability or resources to travel to a regional children’s hospital multiple days per week for traditional in-hospital CR. If our remotely delivered, group based approach for pediatric CR is found to be effective for increasing cardiorespiratory fitness, cardiac function, and other markers of physical and psychosocial health, the implementation of this approach across multiple centers has the potential to improve a patient’s health, wellbeing, and resistance to physiologic stressors, reduce severity of illness and co-morbidities, and potentially lengthen life for children and adolescents with congenital heart disease.

PI_NAMEs: WHITE, DAVID A (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: 19 year old;active control;active control group;Address;Adolescent;Adult;Aerobic Exercise;Age;Alzheimer's Disease;American Heart Association;arm;Asthma;biological sex;boys;Cardiac;Cardiac rehabilitation;cardiorespiratory fitness;Cardiovascular Physiology;career;career development;Caregivers;Characteristics;Child;Childhood;Clinical Trials;Clinics and Hospitals;Common Ventricle;comorbidity;comparison control;Conduct Clinical Trials;congenital heart abnormality;Control Groups;cost;Data;Death Rate;Demographic Impact;design;Development;Diabetes Mellitus;Diagnosis;Dissemination and Implementation;Down's Syndrome;Dual-Energy X-Ray Absorptiometry;Echocardiography;effective intervention;Effectiveness;effectiveness evaluation;Evaluation;Exercise;exercise intensity;exercise intervention;exercise program;exercise rehabilitation;experience;Family;Financial cost;Financial Hardship;fitbit;fitness;frailty;Funding;girls;Goals;Health;Health Technology;heart disorder diagnosis;heart function;Heart Rate;Heart Transplantation;hemodynamics;Home;Hospitals;improved;Intellectual functioning disability;Intervention;Interview;Knowledge;lean body mass;Life;life span;Maximum Heart Rate;meetings;Mentors;mHealth;Mobility decline;Morbidity - disease rate;mortality;Movement;multidisciplinary;novel;obesity treatment;Operative Surgical Procedures;Outcome;Outcomes Research;Parents;Participant;patient retention;Patients;Pediatric Hospitals;pediatric patients;peer;peer support;Personal Satisfaction;Physical activity;Physical Exercise;Physical Function;physiologic stressor;Physiological;Physiology;pilot trial;Population;Preparation;prevent;Prevention;Professional Organizations;programs;psychosocial;psychosocial outcome;Quality of life;Randomized;Randomized Controlled Clinical Trials;remote delivery;remote group;repaired;Research;Research Project Grants;Resistance;resistance exercise;Resources;satisfaction;Schedule;Self Direction;Self Efficacy;Severity of illness;Site;skills;Social support;Structure;Surveys;Tablet Computer;Technology;Tetralogy of Fallot;Time;Training;training project;Transportation;Transposition of Great Vessels;Travel;United States National Institutes of Health;Videoconferencing;Youth

PROJECT_TITLE: Remotely Delivered Cardiac Rehabilitation for Adolescents with Congenital Heart Disease

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


NIH_SPENDING_CATS: Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative The Clinical Genome Resource will make a fundamental contribution to public health care by providing a centralized, sustainable, and easily accessible source of expertly curated information about human genetic variation and its connection to human health. The resource relies on the collaboration of the global genomics community to improve understanding about the genetic basis of disease and to ensure the NHGRI’s mission that genomic advances benefit the health of all people.

PI_NAMEs: BERG, JONATHAN S (contact)

PROGRAM_OFFICER_NAME: VOLPI, SIMONA

PROJECT_TERMS: Acceleration;Address;adjudication;Advocate;annotation  system;Area;Attention;base;Basic Science;Bioinformatics;Caring;Clinical;clinical care;clinical practice;Clinical Sciences;clinically actionable;clinically relevant;Collaborations;Communities;Community Healthcare;computerized tools;crowdsourcing;Data;Data Aggregation;data modeling;Data Set;Data Sources;data standards;Diagnostic;Disease;Disease Management;diverse data;Documentation;Education and Outreach;Electronic Health Record;Ensure;Equity;Etiology;Evaluation;evidence base;Feedback;Funding;Genes;Genetic;Genetic Counseling;Genetic Diseases;genetic resource;Genetic Variation;Genome;genome resource;Genomic medicine;Genomics;Goals;Health;Health Benefit;Health Personnel;Healthcare;Human;Human Genetics;Human Genome;improved;innovation;International;interoperability;Knowledge;Laboratories;Medical Genetics;medical specialties;Methods;Mission;Molecular Genetics;National Human Genome Research Institute;Natural History;Natural Language Processing;Needs Assessment;novel;novel strategies;online resource;Online Systems;outreach;Pathogenicity;Patient Care;Patients;Persons;Phase;Process;Production;Productivity;Program Evaluation;Provider;Public Health;recruit;Reproducibility;Research;Research Personnel;Resources;Rewards;Scientist;skills;Source;Speed;Structure;System;Technology;tool;Training;translational genomics;Translational Research;Trust;United States National Institutes of Health;Variant;volunteer;Work

PROJECT_TITLE: The Clinical Genome Resource – Advancing genomic medicine through biocuration and expert assessment of genes and variants at scale


NIH_SPENDING_CATS: Breast Cancer;Cancer;Complementary and Integrative Health;Dietary Supplements;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Nutrition;Obesity;Prevention;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: We will investigate if gut dysbiosis, characterized by significantly reduced fecal levels of short- chain fatty acids (SCFAs) and the expression of SCFA receptors GPR43/Ffar2 and GPR41/Ffar3, are causally linked to increased mammary tumorigenesis in the offspring of obese dams. We also will investigate if supplementing obese pregnant dams with SCFA producing probiotics and fiber will prevent the increase in mammary tumorigenesis in their offspring.

PI_NAMEs: HILAKIVI-CLARKE, LEENA A. (contact)

PROGRAM_OFFICER_NAME: KUMAR, AMIT

PROJECT_TERMS: Address;Adverse effects;Affect;Age;Agonist;Air Pollution;Allografting;American Indians;anti-tumor immune response;Antibiotics;Bacteria;Biological;Biological Sciences;Birth;Black race;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Risk Factor;C57BL/6 Mouse;CD8-Positive T-Lymphocytes;Cell Physiology;cell type;Cells;Child;Clinical;clinical translation;Clostridiaceae;Cognitive;Communities;Consumption;Crime;CRISPR/Cas technology;Daughter;Diabetes Mellitus;diet-induced obesity;dietary;dietary control;Dietary Fiber;Dietary Intervention;Discipline of Nursing;drinking water;effective intervention;Emotional;Endocrinology;Etiology;Exposure to;fecal microbiota;fecal transplantation;Female;Female of child bearing age;Fetal Tissues;FFAR2 gene;FFAR3 gene;Fiber;Functional disorder;Generations;Goals;Growth;gut bacteria;gut dysbiosis;gut microbes;gut microbiota;health disparity;Human;Immune;immune cell infiltrate;immune function;Immunity;Impairment;Incidence;Individual;Inflammation;Inflammatory;inflammatory marker;Intervention;Intervention Studies;Inulin;Knock-out;Knockout Mice;Life;Link;Long-Term Effects;low socioeconomic status;Malignant Breast Neoplasm;mammary;Mammary Neoplasms;Mammary Tumorigenesis;Mass Spectrum Analysis;maternal obesity;Measures;Mediating;Metabolism;metagenomic sequencing;Microbe;Minnesota;mitochondrial metabolism;mortality;Mouse Mammary Tumor Virus;Mus;Not Hispanic or Latino;obese mothers;Obesity;Obesity Epidemic;obesity in pregnancy;offspring;Organ;Outcome;Play;polyoma middle tumor antigen;Predisposition;Pregnancy;pregnant;Pregnant Women;prevent;Prevention strategy;Prevotella;Probiotics;Production;programs;Public Health;receptor;Reporting;Risk;Role;Shotguns;Signal Transduction;stem cell differentiation;Testing;Tissues;Transplantation;Tumor-infiltrating immune cells;Volatile Fatty Acids;western diet;White Women;Whole Blood;Woman

PROJECT_TITLE: Effect of maternal obesity on breast cancer among offspring: role of the gut microbiota

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Project Narrative This is a 4th competitive renewal application of a successful training program supporting predoctoral and postdoctoral trainees in research on infectious disease, inflammation, and immunology at the University of New Mexico (UNM) Health Sciences Center. Infectious diseases and immuno-pathologies are major public health problems, responsible for a large number of illnesses, and deaths in the United States and worldwide. Through interdisciplinary partnerships among UNM, the Lovelace Respiratory Research Institute, Sandia and Los Alamos National Laboratories, this training program aims to prepare highly skilled researchers whose work will meet the growing needs for lessening the burden of these public health problems in coming decades. !

PI_NAMEs: OZBUN, MICHELLE A (contact)

PROGRAM_OFFICER_NAME: BROWN, LILIANA L

PROJECT_TITLE: Biology of Infectious Disease and Inflammation

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE – UCSF IRACDA Scholars Program Recruiting and retaining exceptional talent from diverse populations is essential for maintaining our nation’s outstanding technical and scientific ranking worldwide. The UCSF IRACDA Scholars Program is addressing this challenge by training highly motivated postdoctoral scholars for academic faculty careers in biomedical research, who often hail from underrepresented groups. Through teaching and mentoring, UCSF IRACDA Scholars, in turn, inspire undergraduate students at our partner institution, San Francisco State University, to enter scientific careers.

PI_NAMEs: ESQUERRA, RAYMOND M.;INGRAHAM, HOLLY A. (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Academia;Achievement;Arkansas;Award;Biomedical Research;California;career;career development;Data;Dedications;Diverse Workforce;Educational process of instructing;Educational workshop;Elements;Environment;Evaluation;experience;Faculty;faculty research;Fostering;Foundations;Funding;Goals;Grant;Health;improved;Institution;Laboratories;meetings;Mentors;next generation;Outcome;Peer Review;Periodicals;Positioning Attribute;Privatization;programs;Publications;Qualifying;Recording of previous events;recruit;Request for Applications;Research;Resources;San Francisco;Scholars Program;Science;Scientist;tenure track;Training;training opportunity;Training Programs;undergraduate student;United States National Institutes of Health;Universities;university student;Writing

PROJECT_TITLE: The UCSF IRACDA Scholars Program.

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: NARRATIVE The body’s full complement of blood and immune cells are generated from a small number of hematopoietic stem cells (HSCs) in regions of the bone marrow termed niches. Niches provide matrix, metabolic, and cell-cell communication signals that influence HSC activity and which evolve over time in response to ageing and disease. The proposed research will develop a tissue engineering model of niche remodeling to selectively expand HSCs ex vivo for therapeutic and experimental applications.

PI_NAMEs: HARLEY, BRENDAN A. (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Aging;analog;Autocrine Communication;Automobile Driving;Biocompatible Materials;bioinformatics tool;biological systems;Biophysics;Blood;Bone Marrow;Bone Marrow Transplantation;cell assembly;cell behavior;Cells;Chemistry;Clinical;clinical care;cohort;Collaborations;Communities;Complement;design;Disease;Ecosystem;Elements;Encapsulated;engineered stem cells;Engineering;exhaustion;extracellular;Extracellular Matrix;Funding;Future;Gelatin;Generations;Goals;Hematology;Hematopoiesis;Hematopoietic;hematopoietic stem cell expansion;hematopoietic stem cell fate;hematopoietic stem cell niche;hematopoietic stem cell quiescence;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hematopoietic System;Hydration status;Hydrogels;Hypoxia;Immobilization;Immune;In Vitro;in vivo;Indiana;infancy;innovation;insight;Investigation;Kinetics;life span;Maps;Marrow;Mediating;medical schools;Mesenchymal;Mesenchymal Stem Cells;Metabolic;Microfluidics;miniaturize;Mission;Modeling;mosaic;mosaic nature;Mus;nanolitre;National Institute of Diabetes and Digestive and Kidney Diseases;paracrine;particle;Pattern;Population;pressure;Process;programs;Property;Regulation;Research;response;self-renewal;Shapes;Signal Induction;Signal Transduction;Spatial Distribution;stem cell fate;stem cells;stemness;Stress;Therapeutic;Time;Tissue Engineering;Tissues;tool;Universities;viscoelasticity;Work

PROJECT_TITLE: Gradient biomaterials to investigate niche regulation of hematopoiesis