NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Rehabilitation;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BIRMINGHAM

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Impairment of information processing is a frequent consequence of stroke. Several interventions have been developed to address this impairment but the transfer of gains made in the treatment setting to everyday life and the retention of these gains is limited. The proposed research is designed to begin the process of evaluating a Transfer Package of behavioral techniques designed to result in: 1) transfer of gains achieved in the treatment setting to everyday life, and 2) result in retention of the real-world gains without decrement for at least 1 year.

PI_NAMEs: BALL, KARLENE K;USWATTE, GITENDRA  (contact)

PROJECT_TERMS: Address;Adult;Affect;Aftercare;arm;Automobile Driving;Basic Science;Behavioral;blood oxygenation level dependent response;care costs;Caregivers;caregiving;Caring;chronic stroke;Cognition;Cognitive;cognitive ability;Cognitive deficits;cognitive function;cognitive rehabilitation;cognitive task;Communities;cost;Data;Dementia;design;Disease;driving performance;Elderly;Evaluation;Exhibits;experience;Family member;follow-up;functional improvement;Impaired cognition;Impairment;improved;Individual;information processing;instrumental activity of daily living;Intervention;Laboratories;Life;Measurement;Measures;Methods;Modeling;Motor;Movement;new combination therapies;novel;Outcome;Participant;Patient Care;Patients;Performance;Persons;post stroke;post stroke cognitive impairment;Prevalence;Procedures;Process;processing speed;Quality of life;Randomized, Controlled Trials;Rehabilitation therapy;Research;Research Personnel;Research Proposals;Sample Size;Sampling;Savings;Signal Transduction;Site;Speed;Stroke;stroke patient;Task Performances;Techniques;Testing;therapy design;Training;treatment effect;Work

PROJECT_TITLE: Transferring Speed of Processing Gains to Everyday Cognitive Tasks after Stroke

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: DAVIS

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE – Project 3  Surveillance mammography is recommended every year for all breast cancer survivors who still have breast  tissue. Unfortunately, it does not work well for all survivors—with 3 out of every 10 second breast cancers  missed. This Project focuses on improving imaging surveillance after breast cancer treatment by: testing a risk  model for breast cancer survivors to receive additional imaging if they are at high risk; validating artificial  intelligence algorithms to see if they can help find more cancers on mammography; and understanding if  conditions where women are born, grow, live, work, and age affect how we find and treat second breast  cancers.

PI_NAMEs: LEE, JANIE M (contact)

PROJECT_TERMS: Address;Adopted;Adoption;Affect;Age;Algorithms;Artificial Intelligence;artificial intelligence algorithm;Asian;Black race;Breast;Breast Cancer Detection;breast cancer diagnosis;Breast Cancer Model;Breast Cancer Surveillance Consortium;Breast Cancer survivor;Breast Cancer Treatment;Cancer Detection;cancer diagnosis;Clinical;Community Practice;Data;deep learning;Disparity;Early Diagnosis;Education;Ensure;Equity;Ethnic Origin;Ethnic Population;Event;Failure;Funding;Future;Goals;head-to-head comparison;health equity;high risk;High Risk Woman;Hispanic;Housing;Image;Image Analysis;improved;Incidence;Income;Individual;Intervention;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammographic screening;Mammography;Measures;Meta-Analysis;model generalizability;Modeling;Morbidity - disease rate;mortality;Neighborhoods;Observational Study;Outcome;Pacific Islander;Performance;Physicians;Policies;Population;predictive tools;primary endpoint;programs;Quality of life;quantitative imaging;Race;racial difference;Racial Equity;racial population;radiologist;Recommendation;Recording of previous events;Recurrence;Registries;Resources;Risk;risk prediction;risk prediction model;risk stratification;screening;secondary endpoint;social health determinants;Specificity;surveillance imaging;Surveillance Modeling;surveillance strategy;Survivors;Technology;Testing;training data;Validation;Woman;Work

PROJECT_TITLE: Project 3


ADMINISTERING_IC: NS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PI_NAMEs: GESCHWIND, DANIEL H (contact)

PROJECT_TERMS: 17q21;3-Dimensional;Address;Affect;age related;Alleles;Architecture;Astrocytes;ATAC-seq;Automobile Driving;Binding;Biological Assay;Brain region;brain tissue;causal variant;Cell Line;Cell Nucleus;cell type;Cells;Chromatin;Chromatin Structure;Chromosome inversion;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Complex;conditioning;CRISPR interference;CRISPR-mediated transcriptional activation;Data;Disease;DNA Footprint;Enhancers;Epigenetic Process;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Gene Expression;Genes;Genetic;Genetic Recombination;Genetic Risk;genetic variant;genome editing;genome wide association study;Genomics;Glutamates;Haplotypes;High Prevalence;Human;Immunohistochemistry;induced pluripotent stem cell;Inheritance Patterns;Lead;Linkage Disequilibrium;Maps;MAPT gene;Measures;Mediating;Microglia;Modeling;Molecular;Molecular Disease;multiple omics;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neurons;novel therapeutic intervention;Nucleic Acid Regulatory Sequences;Pathogenicity;Pathologic;Pathway interactions;Patients;Pattern;Penetrance;Phenotype;Predisposition;Progressive Supranuclear Palsy;promoter;protein expression;Protein Isoforms;Proteomics;rare variant;Regulator Genes;Regulon;Reporter;Reporting;Risk;Risk Reduction;risk variant;screening;Severities;Signal Transduction;single cell genomics;single nucleus RNA-sequencing;Splice-Site Mutation;Spliced Genes;Stress;stressor;tau aggregation;tau mutation;tau Proteins;tau-1;Tauopathies;Testing;Transcript;transcription factor;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Variant;Work

PROJECT_TITLE: Project 2: Impact of H1/H2 haplotypes on cellular disease-associated phenotypes driven by FTD-causing MAPT mutations


NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE – Administrative Core  The Administrative Core will coordinate the organizational, scientific, and fiscal management of our  Program Project to support the individual Projects and Cores. Our Program administration is grounded in  principles of team science including trust and accountability, a shared vision, open communication, defined  roles and responsibilities, and proactive conflict management. Through the Program’s established shared  governance operationalized through effective communication and efficient coordination, the Administrative  Core will enhance synergy across the Program.

PI_NAMEs: MIGLIORETTI, DIANA L (contact)

PROJECT_TERMS: Accountability;Address;anti-cancer research;Attention;Authorship;Breast Cancer Detection;Breast Cancer Surveillance Consortium;breast imaging;Budgets;Collaborations;collaborative environment;Communication;Community Practice;Complex;Computer software;Conflict (Psychology);Data;data sharing;Development;Documentation;Effectiveness;Ensure;Equity;Ethics;Evaluation;experience;Faculty;Feedback;Funding;Funding Opportunities;Goals;Grant;Guidelines;health equity;human subject;Image;imaging facilities;improved;Individual;Infrastructure;International;Journals;Leadership;Malignant Breast Neoplasm;Mammography;Manuscripts;Measurable;meetings;Mentors;Methods;Modeling;Modernization;Monitor;National Cancer Institute;operation;Organizational Models;Outcome;Peer Review;Performance;Persons;Policies;Positioning Attribute;Privatization;Procedures;Productivity;Program Research Project Grants;programs;Progress Reports;Publications;Publishing;Registries;Reporting;Research;Research Personnel;Research Project Grants;Resources;Risk;Role;Running;Schedule;Science;screening;Site;Standardization;Structure;success;synergism;System;Time;timeline;Trust;Vertebral column;virtual;Vision;web site;Woman;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;HIV/AIDS;Heart Disease;Hypertension;Neurosciences;Prevention;Sleep Research

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: NARRATIVE: Cardiovascular disease (CVD) including heart failure, stroke, and myocardial infarction are leading causes of morbidity and mortality in people with HIV worldwide with the highest HIV-attributable CVD risks observed in Africa. Elevated blood pressure at nighttime and poor sleep may contribute to this increased risk of CVD in people with HIV. Our cohort study in Tanzania will be the first to investigate the relationship between nighttime blood pressure, poor sleep, and the onset of CVD in people with HIV and our research findings will inform the design of prevention and treatment interventions to prevent CVD in people with HIV in both Africa and in the United States.

PI_NAMEs: PECK, ROBERT N (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: actigraphy;Adult;Africa;Age;Albuminuria;Ambulatory Blood Pressure Monitoring;Anti-Hypertensive Agents;arterial stiffness;Biometry;Blood Pressure;blood pressure elevation;blood pressure medication;Cardiology;Cardiovascular Diseases;cardiovascular disorder risk;Caring;Cessation of life;Chronic;Clinical Trials;cohort;Cohort Studies;Collaborations;comparative;cost;Cross-Sectional Studies;Data;design;Disease;Diurnal Rhythm;Dose;Epidemic;Epidemiology;Equation;Etiology;Event;falls;Family;Foundations;Functional disorder;Future;Gender;Goals;Guidelines;Health;Heart failure;heart rate variability;HIV;HIV Infections;Hospitals;Hour;Hypertension;Incidence;Inflammation;Insulin Resistance;Intervention;Intervention Trial;Knowledge;Laboratories;Left;Left Ventricular Mass;Longitudinal Studies;Measures;Medicine;Modeling;Monitor;Morbidity - disease rate;mortality;Myocardial Infarction;Natural History;novel;Oxygen saturation measurement;Participant;Pathway interactions;Persons;poor sleep;portability;pre-clinical;premature;Premature Mortality;Prevalence;prevent;Prevention;Renin;Renin-Angiotensin System;Research;Risk Factors;Science;Sleep;Sleep Disorders;sleep health;Stroke;Sympathetic Nervous System;Tanzania;Testing;Time;Time trend;United States;United States National Institutes of Health;Universities;vascular inflammation;Ventricular

PROJECT_TITLE: HIV, Sleep, Nocturnal Non-dipping, and Cardiovascular Disease: a Tanzanian Cohort

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Cancer;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Rare Diseases

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: NARRATIVE Cancer incidence increases with age but the physiological factors that influence this relationship are poorly understood. Our proposal combines somatic tissue engineering and genomics to generate and characterize new models for studying cancer in old mice, producing a broadly portable experimental platform and new information that underlies the contribution of the aging niche to cancer phenotypes.

PI_NAMEs: LOWE, SCOTT W. (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Address;Age;age effect;age related;age related changes;aged;Aging;aging clocks;aging population;aging process;Alleles;animal old age;Animals;biological age;Biology;Cancer Biology;Cancer Intervention;Cancer Model;Cancer Patient;cancer therapy;Cell Physiology;cell type;Cells;Cellular Metabolic Process;chimeric antigen receptor T cells;Chronology;cohort;cost;Development;dietary;Disease;DNA Damage;Engineering;Environment;Environmental Risk Factor;Epigenetic Process;experience;experimental study;Frequencies;Genetic;Genetically Engineered Mouse;Genomics;Genotype;Germ Lines;High Fat Diet;Histologic;human disease;Immune;immune cell infiltrate;improved;in vivo;Incidence;Individual;innovation;insight;interest;juvenile animal;Label;Laboratories;Link;liver cancer model;Malignant neoplasm of liver;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;malignant stomach neoplasm;Methods;Modeling;Molecular;Mus;Mutation;neoplastic cell;normal aging;novel;offspring;old mice;Older Population;Oncogenic;Organ;Phenotype;Physiological;Physiological Processes;Physiology;portability;Process;Production;Reactive Oxygen Species;Resolution;response;Risk Factors;senescent cell;senolytics;Series;single cell analysis;Study models;success;Technology;Testing;Therapeutic;Time;Tissue Engineering;Tissues;tool;Transplantation;tumor;tumor initiation;tumor microenvironment;tumor progression;tumorigenesis;tumorigenic

PROJECT_TITLE: Impact of the aging niche on cancer phenotypes probed using mouse cancer models produced by somatic engineering.


NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Prevention;Social Determinants of Health;Women's Health Research

PHR: PROJECT NARRATIVE – Biostatistics and Data Management Core  The Biostatistics and Data Management Core will collect, manage, analyze, and share data and  mammography images for all Projects. Data collected on 3.0 million women (including 83,000 breast cancer  survivors) from eight breast imaging registries will be combined into common datasets that will be analyzed at  a central Statistical Coordinating Center and made accessible to all Projects and Cores. BDM Core staff will  work closely with Program investigators to ensure high-quality and efficient research practices.

PROJECT_TERMS: Address;anti-cancer research;artificial intelligence algorithm;Benign;Biometry;Biostatistics Core;Breast;Breast Cancer Detection;breast cancer diagnosis;Breast Cancer Surveillance Consortium;Breast Cancer survivor;breast imaging;Cancer Intervention and Surveillance Modeling Network;Cessation of life;cohort;Collaborations;Communities;Community Practice;community setting;comparative effectiveness;Complex;Data;Data Collection;Data Linkages;data management;Data Pooling;data quality;data resource;Data Set;data sharing;Data Sources;data standards;Databases;Diagnostic;Digital Mammography;Effectiveness;Ensure;Equity;Ethnic Population;experience;Focus Groups;Funding;imaging facilities;improved;Individual;Infrastructure;Interview;Link;Longitudinal cohort;longitudinal database;Magnetic Resonance Imaging;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Mammography;Manuscripts;Measurement;Measures;Methods;Modeling;mortality;Neighborhoods;neoplasm registry;novel;Outcome;Pathology;Pathology Report;Policies;Population Heterogeneity;Positioning Attribute;Procedures;programs;prospective;Qualifying;racial population;radiologist;Recording of previous events;Regional Cancer;Registries;Research;Research Design;Research Personnel;Resources;Risk;risk prediction model;Science;screening;Secure;social health determinants;sound;Statistical Data Interpretation;Statistical Methods;study population;success;surveillance imaging;surveillance strategy;System;Time;tomosynthesis;Underserved Population;Woman;Women's cohort;Work;Writing

PROJECT_TITLE: Biostatistics and Data Management Core


ADMINISTERING_IC: HG

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative Genomics is revolutionizing approaches to human health, from the design, analysis, and interpretation of clinical studies to the exploration of the fundamental biology underlying the human condition. Our training program will develop the next generation of genomically literate scientists and engineers.

PI_NAMEs: NIELSEN, RASMUS ;ROKHSAR, DANIEL SOLEYMAN (contact)

PROGRAM_OFFICER_NAME: FUFA, TEMESGEN D

PROJECT_TERMS: Genomics

PROJECT_TITLE: Genomics


ADMINISTERING_IC: EB

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Biotechnology;Duchenne/ Becker Muscular Dystrophy;Gene Therapy;Genetics;Muscular Dystrophy;Pediatric;Rare Diseases

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE Nonsense (stop) mutations lead to truncated proteins and cause many genetically inherited diseases, such as Duchenne muscular dystrophy and cystic fibrosis, and are also common in cancer. We propose a novel approach based on repurposing an endogenous cellular machinery that reinterprets (recodes) UGA stop codons as a selenocysteine amino acid, hence reestablishing translation of the full-length protein. This project, if successful, will lead to effective oligonucleotide-based therapies for a broad spectrum of disorders and diseases.

PI_NAMEs: REGEV, ODED  (contact)

PROGRAM_OFFICER_NAME: DARINGER, NICHOLE MARIE

PROJECT_TERMS: 3' Untranslated Regions;Abbreviations;Address;Adenosine;Affect;Amino Acids;Antisense Oligonucleotides;Binding;Biological Assay;Catalytic RNA;Cell Line;Cell model;Cell Separation;Chemicals;Clinic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Codon Nucleotides;combinatorial;cost;Cystic Fibrosis;Cystic Fibrosis Transmembrane Conductance Regulator;design;Development;Disease;disease-causing mutation;Drug Delivery Systems;Duchenne muscular dystrophy;Elements;Exhibits;exon skipping;Fluorescence;Gene Delivery;gene therapy;Genes;Genetic Diseases;Goals;Hereditary Disease;high reward;high risk;high throughput screening;Human;Inosine;interest;Lead;Length;Luciferases;Malignant Neoplasms;Messenger RNA;Mutate;Mutation;National Institute of Biomedical Imaging and Bioengineering;Nonsense Codon;Nonsense Mutation;novel;novel strategies;novel therapeutic intervention;oligonucleotide therapeutics;Oligonucleotides;Patients;Persons;premature;Production;protein expression;Protein Truncation;Proteins;Quality of life;rare variant;reconstitution;recruit;Reporter;RNA;RNA Editing;Screening Result;Selenocysteine;small molecule;Specificity;Structure;success;System;Technology;technology platform;Terminator Codon;Testing;Therapeutic;Tissues;Toxic effect;Transcript;Translations;Uridine;usability;Virus

PROJECT_TITLE: Readthrough of disease-causing nonsense mutations by targeted selenocysteine recoding

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PHR: PROJECT NARRATIVE – Comparative Effectiveness Core  The Comparative Effectiveness Core provides important services to all three research Projects in the Program.  Core services involving decision science, simulation modeling, and qualitative research with key informant  physician interviews and focus groups of women will help researchers identify the most effective and equitable  ways to provide breast imaging to women at risk for breast cancer.

PI_NAMEs: TOSTESON, ANNA N. A. (contact)

PROJECT_TERMS: Address;Adherence;Adoption;Advanced Malignant Neoplasm;Attention;Biometry;black women;Breast;Breast Cancer Detection;Breast Cancer Risk Factor;Breast Cancer Surveillance Consortium;breast imaging;Cancer Etiology;Cancer Intervention and Surveillance Modeling Network;cancer risk;Caring;Clinical;clinical application;clinical practice;Collaborations;college;Communication;Communication Research;Community Practice;community setting;comparative;comparative effectiveness;Data;data management;Development;Diagnosis;Disparity;disparity reduction;Equilibrium;Equity;ethnic disparity;Evaluation;Fertilization;Focus Groups;Funding;Future;health equity;Health system;High Risk Woman;Image;implementation study;improved;Individual;informant;Infrastructure;innovation;Intervention;Interview;Longitudinal Studies;Malignant Breast Neoplasm;Mammographic screening;medical specialties;Methodology;Methods;Modeling;models and simulation;mortality;multidisciplinary;multimodality;novel;Outcome;Performance;Physicians;Policy Maker;Population;Productivity;program dissemination;programs;Qualitative Research;Quality of Care;racial disparity;Recording of previous events;Registries;Research Personnel;Research Project Grants;Research Support;Resources;Risk;Science;screening;Screening for cancer;Service delivery model;Services;simulation;Site;social health determinants;surveillance strategy;Technology;therapy design;Time;Translating;translational goal;United States;virtual laboratory;White Women;Woman;Women's Group;Women's mortality

PROJECT_TITLE: Comparative Effectiveness Core


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Patient Safety;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: PEDIATRICS

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Public health disasters, such as COVID-19, have disproportionate consequences on low-income and racial- ethnic minority communities through pathways that likely exacerbate disparities associated with poverty and racism, and act over extended periods. Young children are vulnerable to deleterious effects on parent-child relational health and early psychosocial development that will likely result in large adverse consequences for mental health and educational attainment across the life course, but have received less attention and resources. The current application provides a unique opportunity to determine whether population-scalable, healthcare- and community-based, preventive interventions initially targeting pathways of adversity for families living in poverty can prevent widening of disparities anticipated to result from COVID-19, by pooling and harmonizing seven data sets across four studies (including three NICHD R01 awards) in New York City, Pittsburgh, Pennsylvania and Flint, Michigan.

PI_NAMEs: GROSS, RACHEL SHARON;MENDELSOHN, ALAN L. (contact);MORRIS-PEREZ, PAMELA A;SHAW, DANIEL S

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Address;Adverse effects;adverse outcome;Attention;attenuation;Award;Birth;Black race;Buffers;checkup examination;Child;Child Behavior;Child Rearing;Cities;Communities;community intervention;Complex;COVID-19;COVID-19 disparity;COVID-19 health disparity;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Set;design;Development;direct application;Disasters;Disparity;dosage;early childhood;Economics;Education;ethnic disparity;ethnic minority;Ethnic Origin;experience;Exposure to;Family;Family Relationship;feeding;Future;Health;health disparity;Healthcare;informant;Intervention;Language;Latinx;Life Cycle Stages;Link;Low income;Mental Health;Methods;Michigan;minority communities;Minority Groups;National Institute of Child Health and Human Development;New York City;Nursery Schools;pandemic disease;pandemic impact;Parent-Child Relations;parenting intervention;Parents;Participant;Pathway interactions;Pennsylvania;Play;Population;post-COVID-19;Poverty;prevent;Preventive;Preventive Clinical Trial;preventive intervention;programs;prospective;psychosocial development;Public Health;Race;racial disparity;racial minority;racism;Randomized;Reading;Reduce health disparities;Resources;Risk;Role;SARS-CoV-2 exposure;School-Age Population;social;Societies;socioeconomic disadvantage;socioeconomics;stressor;Structure;Testing;Variant;Water

PROJECT_TITLE: Mitigating Adverse Effects of COVID-19 through Preventive Interventions for Families with Young Children Living in Poverty: Linking Data from 3 Cities with Diverse Risks and Exposures

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-J(02)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hypertension;Physical Activity;Prevention;Rehabilitation;Social Determinants of Health;Women's Health Research

ORG_DEPT: FAMILY MEDICINE

PHR: PROJECT NARRATIVE Hypertension is a modifiable risk factor for cardiovascular disease and the most common comorbidity among women with HIV; yet few lifestyle behavior interventions have been adapted for this population. Using a mixed methods approach informed by social cognitive theory, the current project aims to systematically adapt a physical activity intervention supplemented by peer support for women with HIV and hypertension. The adapted behavioral intervention will be pilot tested to assess its acceptability, feasibility, and preliminary impact on blood pressure.

PI_NAMEs: CROCKETT, KAYLEE BURNHAM (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Accelerometer;Address;Affect;Age Years;Aging;Alabama;Applied Skills;Behavior;behavior change;Behavior Therapy;Behavioral;behavioral health intervention;Blood Pressure;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Career Mobility;Clinical;Clinical Investigator;Clinical Trials;Collaborations;Communities;comorbidity;Consultations;Data;design;Development;Diabetes Mellitus;Diastolic blood pressure;Ecological momentary assessment;Education;Educational workshop;Effectiveness;Ensure;evidence base;Evidence based intervention;exercise intervention;expectation;experience;Face;Focus Groups;Foundations;Goals;Guidelines;Health behavior;Health Personnel;HIV;Home Blood Pressure Monitoring;Hypertension;hypertension control;improved;Individual;Institution;International;Intervention;Intervention Studies;Intervention Trial;Interview;K-Series Research Career Programs;Knowledge;Learning;Learning Skill;life span;Life Style;Literature;Maintenance;Measurement;Medicine;meetings;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Minority Groups;Modeling;Moderate Exercise;modifiable risk;Monitor;mortality;multiple chronic conditions;Outcome;Outcomes Research;Patients;peer support;Persons;Physical activity;pilot test;pilot trial;Population;Poverty;prevent;Primary Care;programs;Protocols documentation;Psychological Factors;Quality of life;Randomized;Randomized, Controlled Trials;Research;Research Methodology;Research Project Grants;Resources;Risk;risk mitigation;Risk Reduction;Safety;Sampling;satisfaction;scaffold;Science;Scientist;secondary outcome;Self Efficacy;skill acquisition;skills;social;social cognitive theory;Social Environment;social stigma;Social support;socioenvironmental factor;Southeastern United States;Theory of Change;therapy development;Time;Training;Underserved Population;United States;United States National Institutes of Health;Universities;Woman;Work

PROJECT_TITLE: Adaptation and Pilot Testing a Behavioral Physical Activity Intervention with Peer Support for Women with HIV and Co-Occurring Hypertension

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Kidney Disease;Prevention

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Chronic kidney disease affects > 50% of older adults, 75 years or older, and type 2 diabetes mellitus is the commonest cause of chronic kidney disease. The sirtuin family of nicotinamide adenine dinucleotide (NAD)-dependent deacetylases act as metabolic energy sensors, mediate some of the beneficial effects of caloric restriction on lifespan, and are important regulators of the aging process. NAD augmentation by administration of NAD precursors, such as nicotinamide mononucleotide (NMN), prevents or reverses a number of aging-related conditions, including diabetic kidney disease. Reduced NAD levels in the kidney and aberrant signaling through the sirtuin-NAD pathway are closely linked to the pathogenesis of diabetic kidney disease (DKD) in mice as well as humans, and NMN supplementation prevents the development of DKD and reduces mortality in a mouse model of DKD. The proposed proof-of-principle, Phase 2a, randomized, placebo-controlled, double-blind, parallel group trial will be the first Phase 2a trial to determine the efficacy of NAD augmentation by administration of its precursor, nicotinamide mononucleotide, in older adults, 60 years or older, with type 2 diabetes mellitus and diabetic kidney disease.

PI_NAMEs: BHASIN, SHALENDER  (contact);WAIKAR, SUSHRUT S.

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Adult;Aerobic;Affect;Aftercare;Age;age related;Aging;aging biomarker;aging mechanism;aging process;aging related;Albumins;Albuminuria;Anabolism;attenuation;Bioenergetics;Biological Assay;Biological Markers;Blood Pressure;Caloric Restriction;Cardiac Surgery procedures;Cardiovascular system;Chronic Kidney Failure;Computers;Consensus;Creatinine;Data;Deacetylase;Development;Diabetes Mellitus;Diabetic Nephropathy;Disability scale;Dose;Double-Blind Method;Drug Kinetics;effective therapy;efficacy evaluation;End stage renal failure;Ensure;Epigenetic Process;F2-Isoprostanes;Failure;Family;fasting glucose;Formulation;Glomerular Filtration Rate;glycemic control;Glycosylated hemoglobin A;healthspan;Human;IL6 gene;Impairment;improved;Injury to Kidney;innovation;insulin sensitivity;Insulin-Like Growth Factor I;Kidney;Kidney Failure;late life;life span;Link;Measures;Mediating;Metabolic;Mitochondria;Modification;mortality;mouse model;Mus;Muscle;Niacinamide;Nicotinamide adenine dinucleotide;Nicotinamide Mononucleotide;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;old mice;older adult;Outcome;overexpression;Participant;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patient Self-Report;Patients;Performance;performance based measurement;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Phase;phase I trial;phase III trial;Physical Function;Placebo Control;Placebos;Plasma;Play;Pre-Clinical Model;preclinical study;Prevalence;prevent;primary outcome;Procedures;Public Health;Randomized;Randomized, Controlled Trials;Regimen;Residual state;Risk;Risk Reduction;Rodent Model;Role;Running;sample collection;Sample Size;secondary outcome;sensor;Serum;sex;Signal Transduction;SIRT1 gene;Sirtuins;Stratification;Supplementation;Technology;urinary;Walking;Withholding Treatment

PROJECT_TITLE: NAD Augmentation to Treat Diabetic Kidney Disease: A Randomized Controlled Trial


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Lung;Neurosciences;Pediatric;Sleep Research

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE In children, obstructive sleep apnea (OSA) is evaluated by overnight polysomnography (PSG) in a sleep laboratory, but these facilities are limited, and the test requires caregivers to spend a night away from home with their child. Home sleep apnea testing (HSAT) is a similar test conducted in the home environment, but it is not currently used in children because it has not been directly evaluated against PSG. This trial will compare HSAT with PSG in terms of its accuracy and impact on therapeutic decision for children being evaluated for OSA, and family factors be assessed to determine if HSAT is a good alternative test to PSG.

PI_NAMEs: CIELO, CHRISTOPHER MICHAEL (contact);TAPIA, IGNACIO ESTEBAN

PROGRAM_OFFICER_NAME: BROWN, MARISHKA

PROJECT_TERMS: 12 year old;active method;Adolescent;Adult;Affect;Age;Agreement;Apnea;Arousal;Cardiovascular system;Caregivers;Characteristics;Child;Childhood;Classification;Clinical;clinical center;Clinical Data;clinical practice;Clinical Research;Clinical Treatment;Clinical Trials;comparative effectiveness trial;cost;Data;Decision Making;Devices;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic tool;Down's Syndrome;Electroencephalography;Evaluation;Family;functional outcomes;Gold;Home;Home environment;Hour;indexing;Institutional Review Boards;Knowledge;Laboratories;Left;Logistic Regressions;Masks;Medicine;Metabolic;Methods;Modality;Morbidity - disease rate;neurobehavioral;Obstructive Sleep Apnea;Outcome;Parents;Participant;patient oriented;Patients;Performance;Phase;Physicians;Polysomnography;Population;preference;primary outcome;Procedures;Protocols documentation;Questionnaires;randomized trial;Receiver Operating Characteristics;Recommendation;Reporting;Research Personnel;Resources;Sample Size;Sensitivity and Specificity;Severities;Site;Sleep;Sleep Apnea Syndromes;Test Result;Testing;Therapeutic;Therapeutic Equivalency;Time;Treatment outcome;trial comparing;Youth

PROJECT_TITLE: Home sleep apnea testing compared to in-lab polysomnography for the evaluation of obstructive sleep apnea in children

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(JA)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Assistive Technology;Bioengineering;Chronic Pain;Osteoarthritis;Pain Research;Physical Rehabilitation;Rehabilitation

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE INST FOR BIOMEDICAL/CLINICAL RES

ORG_STATE: WA

PHR: PROJECT NARRATIVE Hallux rigidus (HR) is a painful form of arthritis of the great toe joint that affects nearly half of all females and over one third of all males older than 60; this joint bears loads greater than body weight with each step, and when it becomes stiff and arthritic, this can be very painful. Patients often find non-surgical (i.e., footwear-based) treatments ineffective, while surgical treatments, which can increase motion of the joint (i.e., remove excess bone), remove the joint (i.e., fuse the two bones comprising the joint), or replace the joint (i.e., implant new mating surfaces), have been found to be less than satisfactory. The proposed study will explore healthy and pathologic great toe joint motion, determine the effectiveness of total joint replacements, including a new design developed by our group, at restoring motion, and develop tools to improve the design of these implants.

PI_NAMEs: LEDOUX, WILLIAM R. (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: 3-Dimensional;Activities of Daily Living;Address;Adult;Affect;Age;American;Ankle;Arthralgia;Arthritis;Arthrodesis;arthropathies;Articular Range of Motion;Biomechanics;Body Weight;bone;Bone Spur;Cadaver;Cartilage;Classification;Clinical;Clinical Trials;clinically significant;Complication;cortical bone;Data;Degenerative polyarthritis;design;Development;Device Designs;Devices;Disease;Dorsal;effectiveness evaluation;effectiveness measure;Elements;Environment;evidence base;experience;Failure;Female;Fluoroscopy;foot;Gait;gait examination;Goals;Guidelines;Hallux Rigidus;Head;Hip region structure;hip replacement arthroplasty;Hour;Implant;implant design;improved;Incidence;Individual;ineffective therapies;insight;instrument;Interphalangeal joint of toe;Intervention;iterative design;joint function;joint loading;Joints;kinematics;Kinetics;Knee;knee replacement arthroplasty;Knowledge;Literature;Locomotion;male;Marketing;Mechanics;Metatarsal bone structure;Metatarsalgia;Metatarsophalangeal joint structure;Methods;migration;Modeling;Modification;Motion;Movement;Musculoskeletal;Musculoskeletal Development;novel;older adult;Operative Surgical Procedures;Osteotomy;Outcome;Pain;Partner in relationship;Pathologic;pathomechanics;Patient-Focused Outcomes;Patients;Performance;Phalanx;Physiological;pilates exercise;Population;Positioning Attribute;preservation;Preservation Technique;Prevalence;Process;Property;Prosthesis;Public Health;Quality of life;Randomized, Controlled Trials;rapid testing;Replacement Arthroplasty;Reporting;Research;Resources;Robotics;sample fixation;Sampling;Secondary to;Shapes;Shoes;simulation;Site;success;Surface;Surgeon;systematic review;Technology;Testing;tool;treatment choice;treatment strategy;United States;Validation;Veterans Health Administration;Visit;Walking;Weight-Bearing state;Work;Yoga

PROJECT_TITLE: Characterizing and Restoring Joint Motion in Patients with Hallux Rigidus

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: HOUSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: The central hypothesis of this proposal is that autoantibodies to histone/nucleosome post-translational modifications could exhibit superior diagnostic potential and pathogenic relevance in lupus. The goal of this academia-industry partnership is to test this hypothesis using a novel, high-throughput, spectrally resolved, fluorescent bead-based screening platform bearing a comprehensive battery of post-translational modified nucleosomes/histones in several well-annotated lupus cohorts. The availability of reliable serum biomarkers that can accurately diagnose SLE and renal involvement in lupus can prompt earlier treatment, which has been shown to improve long-term outcome.

PI_NAMEs: MOHAN, CHANDRA  (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: 3-Dimensional;Academia;accurate diagnosis;Acetylation;anti-dsDNA antibodies;Antibodies;Antigens;Antinuclear Antibodies;Apoptotic;Autoantibodies;Autoimmune Diseases;Biological Assay;Biological Markers;Black Box;Cells;Chromatin;cohort;Diagnosis;Diagnostic;diagnostic criteria;Diagnostic Specificity;diagnostic value;Disease;disorder control;DNA;Early treatment;Epigenetic Process;Epitopes;Exhibits;extracellular;Flare;Goals;histone methylation;Histones;improved;Individual;Industrialization;industry partner;innovation;Kidney;Knowledge;Lupus;Lupus Nephritis;Mentored Clinical Scientist Development Program;Methylation;neutrophil;novel;Nucleosomes;Outcome;Pathogenesis;Pathogenicity;Patients;Peptides;Performance;Physiological;pilot test;Post-Translational Protein Processing;Recombinants;Reporting;Research;Scanning;screening;Sensitivity and Specificity;Serum;Specificity;Systemic Lupus Erythematosus;Testing;two-dimensional;Validation

PROJECT_TITLE: Diagnostic utility of antibodies to post-translationally modified nucleosomes in lupus nephritis

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Biotechnology;Genetics;Infectious Diseases;Microbiome;Urologic Diseases

ORG_DEPT: BIOLOGY

PHR: PROJECT NARRATIVE This grant applies a combination of microfluidics, microscopy, synthetic biology, and mathematical modeling to study a broad class of bacterial survival mechanisms known as stochastic switches. The research will reveal the impact of stochastic switching on bacterial aggregation and its consequences for antimicrobial treatment, the variety and molecular mechanisms of antibiotic persistence pathways in E. coli, and the interplay of stochastic switches with recombination in the emergence and maintenance of antibiotic resistant bacteria in the human gut microbiome. The project will yield clinically important findings including the ability to control the genetic pathways that underlie cell-cell aggregation, new strategies for combating and controlling bacterial persistence, and a new understanding of how host-to-host variation and dynamics of the human gut microbiota impacts antibiotic resistance and antigenic variation in bacteria.

PI_NAMEs: KUSSELL, EDO L (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Address;Alleles;Antibiotic Resistance;Antibiotic Therapy;antibiotic tolerance;Antibiotics;Antigenic Variation;antimicrobial;Bacteria;Bacterial Antibiotic Resistance;Bacterial Model;Behavior;Bioinformatics;bioinformatics pipeline;Cell Aggregation;Cell Lineage;Cell Survival;Cell-Cell Adhesion;Cells;Clinical;Code;Collection;cost;Crowding;Custom;Data Set;density;design;Detection;Disease;Ensure;Environment;environmental stressor;Escherichia coli;Exhibits;experimental study;flexibility;Frequencies;Future;Genes;Genetic;genetic approach;Genetic Models;Genetic Recombination;genome sequencing;Genomics;Grant;Growth;gut microbiome;gut microbiota;Heterogeneity;Human;Human Microbiome;Immune response;Immune system;Knowledge;Maintenance;mathematical model;Mediating;Membrane Proteins;metagenomic sequencing;Metagenomics;Methods;microbiome;microbiome research;Microfluidic Microchips;Microfluidics;Microscopy;Molecular;Natural regeneration;non-genetic;novel;pathogen;pathogenic bacteria;Pathogenicity;Pathway interactions;Phase;Phenotype;Physiological;Population;Population Genetics;Process;promoter;Proteins;Public Health;Quantitative Microscopy;Recovery;Regulation;Reporter;Research;Resistance;resistance gene;Role;Sampling;small molecule inhibitor;Stress;Surface Antigens;synthetic biology;Time;transcriptomics;transmission process;Urinary tract infection;Uropathogenic E. coli;Variant;whole genome

PROJECT_TITLE: Revealing Stochastic Switches in Bacteria

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Cerebral Palsy;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: FLAGSTAFF

ORG_NAME: NORTHERN ARIZONA UNIVERSITY

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Many children with cerebral palsy have difficulty walking, which contributes to drastically reduced levels of physical activity and lower quality of life. This proposal seeks to address ambulatory impairment in cerebral palsy by investigating the use of wearable ankle assistance for mobility augmentation and targeted ankle resistance for gait training. The long-term goal of this work is to establish a holistic, evidence-based ankle therapy for cerebral palsy that increases physical activity and community participation.

PI_NAMEs: LERNER, ZACHARY FOREST (contact)

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: Address;Affect;Age;Ankle;Biofeedback;Cardiovascular Diseases;Cerebral Palsy;Characteristics;Child;Childhood;Clinical;Community Participation;comparison control;comparison intervention;Consensus;cost;critical period;Cues;Development;disability;Dorsal;Dose;effective therapy;Effectiveness;efficacy evaluation;energy efficiency;evidence base;Family;Flexor;foot;Functional disorder;functional improvement;functional outcomes;Future;Gait;Gait abnormality;gait rehabilitation;Gender;Goals;Guidelines;Home;Impairment;improved;improved mobility;Individual;innovation;Intervention;Knowledge;Length;light weight;Lower Extremity;Measures;Mechanics;Metabolic;Metabolic dysfunction;mobility aid;Mobility decline;motor control;Muscle;Muscle function;neuromuscular;Operative Surgical Procedures;Orthopedic Surgery;Orthotic Devices;Outcome;Participant;Pattern;peer;Performance;Personal Satisfaction;personalized intervention;Physical activity;physical conditioning;Physical therapy;physically handicapped;Pilot Projects;post intervention;Precision therapeutics;Protocols documentation;Quality of life;Ramp;Randomized, Controlled Trials;Resistance;resistance exercise;Rhizotomy procedure;robot exoskeleton;robotic device;Robotics;Running;Severities;Shoes;spasticity;Speed;standard of care;strength training;Techniques;Testing;theories;Training Programs;treadmill;treadmill training;United States;United States National Institutes of Health;Visit;Walking;walking speed;wearable device;Work

PROJECT_TITLE: Augmenting Ankle Plantarflexor Function and Walking Capacity in Children with Cerebral Palsy


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Genetic Testing;Genetics;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Detection of PDAC at an early stage positively impacts survival, and screening in eligible high-risk individuals (HRIs) defined by family history and mutation status is considered best practice. The overall goal of this proposal is to use our accumulated knowledge to considerably enhance use of new blood protein and methylated DNA (MDM) biomarkers for early detection of PDAC. We will leverage our extensive biospecimen resources to test whether a combination of proteins, MDMs, and CA19-9 will accurately identify early stage PDAC in HRIs.

PI_NAMEs: MAJUMDER, SHOUNAK  (contact);ZARET, KENNETH

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Address;Age;Algorithms;biobank;Biological Assay;Biological Markers;Biological Specimen Banks;biomarker development;biomarker panel;biomarker validation;Biometry;Blinded;Blood;blood product;Blood Proteins;Blood specimen;CA-19-9 Antigen;Cancer Detection;Cancer Etiology;Cancer-Predisposing Gene;Centers of Research Excellence;Cessation of life;Characteristics;Clinic;clinical effect;clinical translation;cohort;Collection;Cyst Fluid;design;Detection;Development;Diabetes Mellitus;Diagnosis;Diagnostic;diagnostic accuracy;Discrimination;Disease;disorder control;DNA Markers;DNA Methylation;early detection biomarkers;Early Diagnosis;Early identification;early onset;Eligibility Determination;Epidemiology;Evaluation;experience;Familial pancreatic cancer;Family;Family history of;Gastroenterology;General Population;Genetic;Genetic Predisposition to Disease;Germ-Line Mutation;Goals;Grant;Guidelines;high risk;high risk population;improved;Incidence;Individual;individual patient;Infrastructure;innovation;kindred;Knowledge;Leadership;Longitudinal cohort;Malignant neoplasm of pancreas;Malignant Neoplasms;Mass Spectrum Analysis;Measurable;member;Methodology;Methods;multidisciplinary;mutational status;new technology;Non-Malignant;novel;novel marker;novel strategies;Pancreas;Pancreatic Cyst;Pancreatic Diseases;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Participant;patient variability;Patients;Pennsylvania;Performance;Phase;phase 2 designs;phase 2 study;phase 2 testing;phase 3 study;phase 3 testing;Plasma;Population;Procedures;prospective;protein biomarkers;Proteins;Protocols documentation;Race;Recommendation;Recording of previous events;recruit;Resources;Risk;Risk Factors;sample collection;Sampling;screening;Screening for cancer;sex;Smoking;Standardization;stem cell model;Survival Rate;Symptoms;Testing;THBS2 gene;Time trend;Tissues;tool;United States;Universities;Validation

PROJECT_TITLE: Mayo Clinic Prospective Resource for Biomarker Validation and Early Detection of Pancreatic Cancer


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Genetics;HIV/AIDS;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: Los Alamos

ORG_NAME: TRIAD NATIONAL SECURITY, LLC

ORG_STATE: NM

PHR: Narrative Combining evolutionary theory, multi-scale dynamic modeling, and large-scale clinical and sequence data will transform how epidemics are investigated and prevented. Melding these resources, we will develop innovative methods for HIV epidemiological analyses and prevention efforts.

PI_NAMEs: LEITNER, THOMAS K. (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Address;Affect;Artificial Intelligence;Biological Assay;Biological Markers;Biology;Clinical;convolutional neural network;Data;Data Set;detection method;Disease Outbreaks;Epidemic;Epidemiologic Methods;Epidemiology;Event;Evolution;experience;fitness;follow-up;Future;Genetic;Genetic Recombination;Goals;Guide prevention;Heterogeneity;HIV;HIV Infections;Immune response;improved;Individual;Infection;innovation;large datasets;Length;Link;Machine Learning;machine learning method;Mathematics;Methods;Minority Groups;Modeling;Modernization;Molecular Biology;Monitor;multi-scale modeling;Mutation;next generation;next generation sequence data;pathogen;Patients;Persons;Phylogenetic Analysis;Phylogeny;Population;pressure;prevent;Prevention;Process;Publishing;reconstruction;Recording of previous events;Research Personnel;Resources;Sampling;Signal Transduction;Statistical Models;System;theories;Time;tool;transmission process;Trees;Work

PROJECT_TITLE: Reconstructing HIV Epidemics from HIV Phylogenetics


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: The genetic material is packed into the nucleus via the formation of long-range chromatin loops. We propose to examine and control the formation and dissolution of chromatin loops in real time in a variety of biological processes across a range of biological time scales, from minutes (neuronal firing), to hours (exit from mitosis), to weeks (cellular reprogramming). We will develop and apply new live cell DNA and RNA imaging technologies, inducible synthetic architectural proteins, and DNA sequencing to understand the 3D genome's structure-function relationship in living cells.

PI_NAMEs: BLOBEL, GERD A;PHILLIPS-CREMINS, JENNIFER ELIZABETH (contact);QI, LEI STANLEY;RAJ, ARJUN

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: 3-Dimensional;Adopted;Amalgam;Architecture;base;Biological;Biological Models;Biological Process;biological systems;cancer cell;cancer therapy;Cell Cycle Stage;cell fixing;Cell Nucleus;Cell Reprogramming;Cell Separation;cell type;Cells;cellular imaging;Characteristics;ChIP-seq;Chromatin;Chromatin Loop;Clustered Regularly Interspaced Short Palindromic Repeats;cohesin;Collaborations;Complex;Data;design;Development;DNA;DNA sequencing;Electric Stimulation;Engineering;Enhancers;Epigenetic Process;Erythroid Cells;Event;experimental study;Frequencies;G1 Phase;Gene Expression;Genes;Genetic Materials;Genetic Transcription;Genome;Genome engineering;Genome Mappings;genome-wide analysis;Hi-C;Hour;Human;Image;Imaging Device;Imaging Techniques;Imaging technology;Immediate-Early Genes;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;insight;interest;Light;Link;live cell imaging;mammalian genome;Maps;Measures;Mediating;Melanoma;Metaphase;Methodology;Mitosis;Mitotic;Monitor;Mus;Neurobiology;Neurons;new technology;Peptide Sequence Determination;Pharmaceutical Preparations;Phase Transition;Phenotype;pluripotency;Population;Precision Run-On Sequencing;Productivity;promoter;Proteins;Qi;Reporter;Research Personnel;Resistance;Resolution;response;RNA;Role;single cell genomics;single molecule;Somatic Cell;Stimulus;Structure;Structure-Activity Relationship;System;Technology;technology platform;Testing;Time;time use;tool;Transcript;ultra high resolution;Visualization;YY1 Transcription Factor

PROJECT_TITLE: Engineering and Imaging 3D genome structure-function dynamics across time scales

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-A(70)R]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Nutrition;Obesity

ORG_CITY: AMHERST

ORG_DEPT: DENTISTRY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: PROJECT NARRATIVE Periodontitis is a common chronic inflammatory disease characterized by destruction of the supporting structures of the teeth. Although there is a clear relationship between degree of obesity and periodontal disease incidence, the mechanisms that underpin the links between these two conditions are not completely understood. This application seeks to understand the impact of immature myeloid cells in obesity-associated periodontal disease which will provide mechanistic insight linking obesity and dietary changes with oral bone quality in health and disease.

PI_NAMEs: KIRKWOOD, KEITH L (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: adipokines;Adult;Affect;alveolar bone;Alveolar Bone Loss;alveolar destruction;Architecture;bone;bone loss;bone quality;Cardiovascular Diseases;Cells;Chronic;chronic inflammatory disease;cohort;comorbidity;Complex;cytokine;Diabetes Mellitus;Diet;diet-induced obesity;dietary;Disease;Disease Progression;Disease susceptibility;Enzymes;Exposure to;Flow Cytometry;Functional disorder;Funding Opportunities;Future;gain of function;Genetic;Gingiva;Health;Human;Hyperglycemia;Immune;immune function;Immune system;Immunophenotyping;in vivo imaging;Incidence;Inflammation;Inflammation Mediators;insight;Label;Leucocytic infiltrate;Link;Lipopolysaccharides;loss of function;Macrophage;Memory;Metabolic;Metabolic Diseases;Metabolism;microbial colonization;Molecular;monocyte;Mucosal Immunity;Mus;Myeloid Cells;Myeloid-derived suppressor cells;Nonesterified Fatty Acids;obese patients;Obesity;obesity development;Oral;Oral cavity;osteoclastogenesis;Osteoclasts;osteoimmunology;Patients;Periodontal Diseases;Periodontal Infection;Periodontitis;Periodontium;peripheral blood;Phenotype;Play;Population;Process;Production;Quality of life;recruit;Regulation;response;Risk Factors;Role;Severities;Site;systemic inflammatory response;Therapeutic;Thinness;Tissues;Training;transcriptome sequencing;transcriptomics

PROJECT_TITLE: Immunometabolic Regulation of MDSCs in Periodontitis

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation

ORG_CITY: Chicago

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: The presence of mild cognitive impairment (MCI) in older adults increases their fall risk. Although reasons for the higher prevalence of falls in MCI are still not clear, neurodegenerative changes observed in this pathology result in cognitive, physiological and functional deficits, which contribute to risk of falls. Despite knowing the benefits of reactive balance training on reducing fall risk, and cognitive training on improving cognitive functions in healthy older adults (OA), the effectiveness of these therapeutic strategies in reducing risks of falls in MCI when administered simultaneously is not yet established. Therefore, this study aims to examine the biomechanics, neuromuscular, and cortical mechanisms involve in reactive balance strategies after gait and stance perturbations, and to test a novel training paradigm including a task-specific reactive balance approach with cognitive training in MCI population.

PI_NAMEs: BHATT, TANVI  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Adherence;Adverse effects;Affect;Area;Attention;Awareness;Balance training;Biomechanics;Brain;Cognition;Cognitive;Cognitive deficits;cognitive function;cognitive task;cognitive training;cost effective intervention;Defense Mechanisms;Dementia;Deterioration;Economics;Effectiveness;Equilibrium;Executive Dysfunction;executive function;experience;Exposure to;Fall prevention;fall risk;falls;fear of falling;Gait;gray matter;Health;High Prevalence;Impairment;improved;Incidence;Individual;Intervention;Laboratories;Lesion;Life;Limb structure;Literature;Measures;Mechanics;mild cognitive impairment;Motor;motor disorder;motor learning;Muscle;Musculoskeletal Equilibrium;Nerve Degeneration;neural correlate;Neuromechanics;neuromechanism;neuromuscular;neurophysiology;novel;older adult;Pathology;Pattern;Performance;Persons;Physiological;Pilot Projects;Play;Population;Predisposition;Prevalence;preventive intervention;Probability;prospective;Psychological Factors;Quality of life;recruit;Research;Resources;response;Rest;risk mitigation;Risk Reduction;Role;Sensory;sensory integration;skills;Speed;Structure;synergism;Task Performances;Testing;therapeutic effectiveness;Training;treadmill;visual motor;white matter

PROJECT_TITLE: Neuromechanisms of falls in older adults with MCI: Targeting assessment and training of reactive balance control


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Neurosciences

ORG_CITY: MISSISSIPPI STATE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: MISSISSIPPI STATE UNIVERSITY

ORG_STATE: MS

PHR: 8. Project Narrative Current therapeutics are not sufficiently effective to protect lives and brain function following poisoning by highly toxic organophosphates such as nerve agents. A series of novel compounds has shown efficacy as antidotes in promoting survival of laboratory animals poisoned by nerve agent surrogates, and a lead compound has been identified for further development. This project would produce data to further characterize the lead compound with additional survival efficacy tests, and pharmacology and toxicology information in two animal species to support this potential drug proceeding into future advanced development and ultimately FDA approval.

PI_NAMEs: CHAMBERS, JANICE ELAINE (contact)

PROGRAM_OFFICER_NAME: SPRIGGS, SHARDELL M

PROJECT_TERMS: Accidents;Acetylcholinesterase;active method;Advanced Development;Affinity;animal poison;Animals;antagonist;Antidotes;Atropine;Attenuated;attenuation;Behavior;Binding Proteins;blood-brain barrier penetration;Brain;Cavia;Chemicals;Chemistry;Cholinesterase Inhibitors;Clinical Chemistry;commercialization;Consultations;Convulsions;Data;Development;dosage;Dose;Drug Interactions;Drug Kinetics;efficacy testing;Evaluation;experimental study;Exposure to;Future;genotoxicity;Goals;Hematology;Hepatic;Human;improved;In Vitro;in vivo;Intellectual Property;invention;Laboratories;Laboratory Animals;Lead;lead optimization;Legal patent;Licensing;Licensure;Life;lipophilicity;male;manufacture;mass casualty;meetings;Metabolism;Methods;methylphosphonate;Microsomes;Miniature Swine;Muscarinic Acetylcholine Receptor;nerve agent;neuropathology;neuroprotection;No-Observed-Adverse-Effect Level;novel;organophosphate poisoning;Organophosphates;Oximes;Pathologic;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Pharmacologic Substance;Pharmacology;Pharmacology and Toxicology;Plasma;Plasma Proteins;Poison;Poisoning;pre-Investigational New Drug meeting;preservation;Probability;Property;Property Rights;Qualifying;Rattus;Recurrence;Research;respiratory;response;Safety;Sarin;scale up;Seizures;Series;sex;Solubility;Solvents;Specific qualifier value;Testing;Therapeutic;Toxic effect;Toxicology;Tremor

PROJECT_TITLE: Optimization of Substituted Phenoxyalkyl Pyridinium Oximes as Therapies for Organophosphate Poisoning


NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Kidney Disease;Urologic Diseases

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Pyelonephritis or kidney infections with bacteria that are resistant to antibiotics have increased dramatically. For example, uropathogenic Escherichia coli (UPEC) isolates resistant to sulfamethoxazole/trimethoprim now exceed 20% in most areas of the world. This proposal aims to understand how the kidney employs certain cells to consume invading bacteria which would provide the basis to begin to develop strategies that enhance the kidney’s defenses to replace or complement traditional antibiotic thera

PI_NAMEs: HAINS, DAVID SULLIVAN;SCHWADERER, ANDREW LAWRENCE (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Acetazolamide;Acid-Base Equilibrium;Acids;Anti-Bacterial Agents;anti-microbial peptide;Antibiotic Resistance;Antibiotics;Area;Bacteria;bacterial resistance;bactericide;base;Biological;Biological Assay;Biological Models;Blood;carbonate dehydratase;Cell Physiology;Cell secretion;Cell Separation;Cells;Collecting Cell;Communication;Complement;Consumption;Data;Ductal Epithelial Cell;Enzymes;Epithelium;Escherichia coli;experimental study;Flow Cytometry;Foundations;Goals;Health Care Costs;Healthcare;Homeostasis;Human;Immune;In Vitro;in vivo;Infection;infection risk;Injury to Kidney;Intercalated Cell;intravital microscopy;Invaded;Kidney;kidney cell;kidney infection;Knock-out;Knowledge;Macrophage;Magnetism;Methodology;Microbe;microbicide;Modeling;Morbidity - disease rate;mortality;Mus;Nature;novel strategies;novel therapeutic intervention;Organism;particle;Pathway Analysis;Pathway interactions;Pattern recognition receptor;Phagocytes;Phagocytosis;Phagosomes;pharmacologic;Populations at Risk;Predisposition;preservation;prevent;Process;Proton Pump;PTPRC gene;Publishing;real-time images;Regulation;Renal function;Research;Risk;RNA;Role;Sentinel;Signal Pathway;single cell mRNA sequencing;Site;spatiotemporal;Testing;Time;treatment strategy;Trimethoprim-sulfamethoxazole drug resistance;Urinary tract;Urinary tract infection;Urine;Uropathogen;Uropathogenic E. coli;vacuolar H+-ATPase;Visualization;Work

PROJECT_TITLE: Harnessing the acid-base cellular machinery of intercalated cells in the bacterial defense of the kidney

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Mental Health;Neurosciences

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: PUBLIC HEALTH RELEVANCE STATEMENT (Three Sentences) Despite the success of the existing human brain imaging technologies, next-generation imaging tools are strongly desired. We propose to develop fast and ultrafast 3D photoacoustic computed tomography for high- resolution brain activity imaging based on the state-of-the-art technologies. This new modality has the advantages of high imaging speed, high spatial definition, high sensitivity, low background, rich signal contrast, open and magnet-free imaging, bedside and quiet operation, and low maintenance cost.

PI_NAMEs: WANG, DANNY JJ;WANG, LIHONG  (contact)

PROGRAM_OFFICER_NAME: WANG, SHUMIN

PROJECT_TERMS: 3-Dimensional;Acoustics;Address;Adult;Algorithms;Atlases;Attenuated;attenuation;Back;Blood flow;blood oxygen level dependent;Blood Vessels;Brain;Brain imaging;BRAIN initiative;Breast;Cephalic;Complement;Cortical vasculature;cost;cranium;Data;deoxyhemoglobin;Dependence;Detection;Development;diffuse optical tomography;Diffusion;Doppler Effect;Electric Stimulation;Electronics;Elements;Environment;frontier;Functional Imaging;Functional Magnetic Resonance Imaging;functional near infrared spectroscopy;Goals;hemodynamics;Human;human imaging;human subject;Image;image reconstruction;imaging capabilities;Imaging Device;imaging modality;imaging platform;Imaging technology;improved;in vivo;Light;Magnetic Resonance Imaging;Maintenance;Maps;metabolic imaging;Methods;Microscopic;Modality;Modeling;Mus;neural;Newborn Infant;next generation;Noise;novel;novel strategies;operation;Organ;Oxyhemoglobin;photoacoustic imaging;portability;Positron-Emission Tomography;Process;public health relevance;Radioactive Tracers;Rattus;reconstruction;recruit;Resolution;response;Rest;Rodent;Running;Sampling;Signal Transduction;Site;spatiotemporal;Speed;Statistical Data Interpretation;Structure of fontanel of skull;success;Surface;System;Techniques;Technology;temporal measurement;Thalamic structure;Thick;Time;Tissues;Translating;Ultrasonic Transducer;Ultrasonic wave;Ultrasonics;ultrasound;Variant;Vibrissae;X-Ray Computed Tomography

PROJECT_TITLE: Massively parallel high-speed 3D functional photoacoustic computed tomography of the adult human brain


NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Networking and Information Technology R&D (NITRD)

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Cell fate decisions are essential for development and the maintenance of organs throughout life, thus understanding them underlies health challenges ranging from developmental disorders to cancer. This project will develop computational methods using genomic data to study the dynamic gene expression programs that control cell fate decisions. The result will be new tools with which to study dynamic cellular processes in single cells.

PI_NAMEs: MACLEAN, ADAM L (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Address;ATAC-seq;Bayesian Method;Body System;Cell Communication;Cell Differentiation process;Cell Fate Control;Cell model;Cell Physiology;Cell Reprogramming;Cells;Classification;Collaborations;Computer Models;Computing Methodologies;Coupled;Data;data modalities;Decision Making;Development;developmental disease;Differential Equation;Equilibrium;Gene Expression;gene network;gene regulatory network;Genes;Genetic Transcription;genomic data;Genomics;Goals;Health;Hematopoiesis;insight;intercellular communication;learning network;Life;machine learning model;Maintenance;Malignant Neoplasms;Methods;Modeling;Molecular;multi-scale modeling;Myelogenous;Myeloid Cells;nephron progenitor;open source;Organ;Pattern;predictive modeling;programs;Research;Resolution;Series;Signal Transduction;single-cell RNA sequencing;skin regeneration;Statistical Methods;Statistical Models;stem cell fate;System;Testing;Time;tool

PROJECT_TITLE: Computational methods to predict gene regulatory network dynamics and cell state transitions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Cystic Fibrosis;Infectious Diseases;Lung;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Epithelial mucin overproduction that leads to airway mucus obstruction is a hallmark of cystic fibrosis (CF). IRE1β is a protein responsible for airway epithelial mucin production. By evaluating the functional role of IRE1β in CF models of mucin overproduction, our studies may lead to IRE1β inhibitors as novel therapeutics for CF patients.

PI_NAMEs: RIBEIRO, CARLA MARIA PEDROSA (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Address;Affect;Airway Disease;airway epithelium;airway inflammation;Amino Acids;Anti-Inflammatory Agents;aspirate;Asthma;Bacterial Infections;Binding;Binding Proteins;Birth;bronchial epithelium;Bronchiectasis;Bronchiolitis;Cells;Child;Chronic;Clinic;Cystic Fibrosis;cystic fibrosis airway;cystic fibrosis airway epithelia;cystic fibrosis mouse;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;cytokine;Cytoplasm;Cytoplasmic Tail;Data;Distal;efficacy testing;Endoplasmic Reticulum;endoplasmic reticulum stress;Enzymes;Epithelium;Exhibits;Feedback;Gastrointestinal tract structure;Generations;Genetic;Human;idiopathic pulmonary fibrosis;Impairment;infant infection;Inflammation;inhibitor;innovation;Inositol;Integral Membrane Protein;Interleukins;Mammals;MAPK8 gene;Mediating;Medical;Messenger RNA;Modeling;MUC5AC gene;MUC5B gene;Mucins;Mucous body substance;Mus;mutant;neutrophil;new therapeutic target;novel therapeutics;Obstruction;overexpression;p38 Mitogen Activated Protein Kinase;Para-Influenza Virus Type 1;Pathway interactions;pharmacologic;Phosphotransferases;preclinical evaluation;Preclinical Testing;prevent;Production;Protein Isoforms;Proteins;Pulmonary Cystic Fibrosis;Regulation;respiratory infection virus;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Respiratory System;response;Ribonucleases;RNA Splicing;Role;sensor;Signal Pathway;targeted treatment;Tertiary Protein Structure;Testing;Therapeutic Effect;TNF gene;transcription factor;Viral Bronchiolitis;Virulence Factors;Virus Diseases;VX-770

PROJECT_TITLE: Pre-Clinical Evaluation of IRE1beta as a Novel Therapeutic Target for Cystic Fibrosis Airway Mucus Production

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-N(03)]


NIH_SPENDING_CATS: Aging;Biotechnology;Cardiovascular;Clinical Research;Diabetes;Estrogen;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Human Genome;Prevention;Women's Health Research

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Cardiovascular events, such as heart attacks and strokes, are the leading cause of death in women and occur more frequently in transgender individuals undergoing gender affirming hormone therapy. This project utilizes genomics in women and transgender individuals undergoing therapy to identify sex and gender specific cardiovascular disease genes that will inform clinical screening and therapy in these groups.

PI_NAMEs: MAJITHIA, AMIT  (contact)

PROGRAM_OFFICER_NAME: PUGGAL, MONA A

PROJECT_TERMS: Adipocytes;Adipose tissue;Alleles;biobank;Biological Assay;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;causal variant;Cause of Death;Cells;Cellular Assay;cis-female;Clinical;clinical effect;clinical phenotype;Code;Communities;Credentialing;Data;Development;Diabetes Mellitus;differential expression;Disease;Disparity;Dose;Environmental Risk Factor;Estrogens;Event;Exclusion;exome sequencing;experimental study;Female;Fracture;Functional disorder;Gender;gender affirmation;gender affirming hormone therapy;gene discovery;Gene Expression;gene function;General Population;Genes;genetic analysis;genetic association;Genetic Code;genetic risk factor;genetic variant;Genome engineering;genome wide association study;Genomic approach;Genomics;Genotype;genotypic sex;Gonadal Steroid Hormones;Health;health record;Heritability;High Density Lipoproteins;high risk;high throughput screening;hormone therapy;Hormones;Human;Individual;Insulin;Insulin Resistance;insulin sensitivity;Investigation;Laboratories;Lipodystrophy;loss of function;male;Mediating;Medical;Medical Research;men;Metabolic Diseases;Molecular;Mus;Mutation;Myocardial Infarction;novel;novel therapeutics;osteoporosis with pathological fracture;Ovarian;Participant;Persons;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiological;Population;Postmenopause;PPARG gene;predictive marker;Predisposition;premature;prevent;Production;prospective;Proteins;Research;resistance gene;response;Risk;Risk Factors;RNA Sequences;Role;screening;Series;Severities;sex;Sex Chromosomes;Sex Differentiation;sexual dimorphism;side effect;Stroke;System;targeted treatment;Testing;therapeutic gene;Thiazolidinediones;Tissue Donors;Tissue Sample;Tissues;transcriptome;transcriptome sequencing;transgender;transgender women;Triglycerides;Variant;Vulnerable Populations;Woman;Women's mortality;Work

PROJECT_TITLE: Credentialing novel cardiovascular disease genes in women by sex-specific genomic investigation of insulin resistance


NIH_SPENDING_CATS: Arthritis;Chronic Pain;Clinical Research;Genetics;Human Genome;Osteoarthritis;Pain Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: ORTHOPEDICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Femoroacetabular impingement (FAI) has an etiologic role in up to 50% of hip osteoarthritic cases. While hip bone deformity has been well characterized in FAI, a major knowledge gap exists regarding the molecular and epigenetic events involved in disease progression. The goal of this research project is to identify critical biologic events, specifically transcriptome and methylation pathways involved in progression of hip osteoarthritic disease.

PI_NAMEs: PASCUAL-GARRIDO, CECILIA  (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: ADAMTS;Address;Adult;Amino Acids;Aminobutyric Acids;Animal Model;Antibodies;Arthritis;articular cartilage;ATAC-seq;Attenuated;Bioinformatics;Biological;Biological Process;bone;Cadaver;Caring;Cartilage;Cells;Chondrocytes;Chromatin;chromatin immunoprecipitation;Clinical;Collaborations;collagenase 3;CpG Islands;Data;Deformity;Development;Diagnostic;Disease;Disease Progression;DNA;DNA Methylation;DNMT3B gene;Doctor of Philosophy;Education;Enhancers;Epigenetic Process;epigenomics;Etiology;Event;experience;Femur;femur head;follow-up;Future;gamma-Aminobutyric Acid;Gene Expression;Genes;genome wide methylation;Goals;Health Services Research;hip bone;Hip Joint;Hip Osteoarthritis;Hip region structure;Homeostasis;Human;Immune response;improved;Individual;Inflammation;Inflammatory;Injury;Institution;Interleukin-1 beta;Intervention Studies;K-Series Research Career Programs;Knee Osteoarthritis;Knowledge;loss of function;Medial;Mediator;medical schools;Methylation;Modeling;Molecular;Mus;Musculoskeletal;neutrophil;NF-kappa B;novel;Operative Surgical Procedures;Oryctolagus cuniculus;Pathogenesis;Pathologic;Pathway interactions;Patient Care;Patient Outcomes Assessments;Patients;Phenotype;Play;postnatal;preservation;Process;programs;promoter;reconstruction;Reporting;Research;Research Personnel;Research Project Grants;Research Training;Role;Sampling;Scientist;Secondary to;Signal Transduction;skills;Stains;Surgeon;Testing;Therapeutic Intervention;Total Hip Replacement;Training;Transcript;transcriptome;transcriptome sequencing;Transferase;Transforming Growth Factor beta;Translations;Universities;Washington;Western Blotting;Work;young adult

PROJECT_TITLE: Mediators of the OA Cascade in the Pre-Arthritic Hip

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Genetics;Human Genome

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative The proposed research is relevant to public health because understanding gastrointestinal eosinophils and their heterogeneity and subtypes is expected to contribute to better diagnostics and treatments of a variety of gastrointestinal eosinophilic diseases. Thus, this proposal is relevant to the part of NIH's mission that pertains to fostering fundamental creative discoveries and innovative research strategies as a basis for ultimately protecting health.

PI_NAMEs: ROTHENBERG, MARC E. (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Ablation;Acetylation;Activities of Daily Living;Advisory Committees;Allergic Disease;Antigen Presentation;ATAC-seq;Binding Sites;Biological Assay;Biological Process;Blood;Bone Marrow;CD4 Positive T Lymphocytes;Cell Physiology;Cells;chemokine;ChIP-seq;Chronic;Clinical;Coculture Techniques;Complex;Creativeness;Cues;cytokine;Diagnostic;Disease;Distal;Enhancers;eosinophil;Eosinophilic Gastrointestinal Disease;Eotaxin;Epigenetic Process;epigenetic regulation;epigenome;epigenomics;Epithelial Cells;Epithelium;Erythropoietin;Estrus;Fostering;Foundations;gastrointestinal;gastrointestinal function;Gastrointestinal tract structure;Gene Expression;Genes;Genetic Transcription;Genome;Goals;Grant;granulocyte;Granulocyte-Macrophage Colony-Stimulating Factor;Health protection;Heterogeneity;Histones;Homeostasis;Human;Hypersensitivity;IL3 Gene;Immunology;immunoregulation;Individual;Inflammatory;innovation;Interleukin-13;Interleukin-5;Lead;Leukocytes;lipid metabolism;Lysine;Malignant Neoplasms;mammary gland development;MicroRNAs;Mission;Modeling;Mucous Membrane;Mus;new therapeutic target;novel drug class;Parasites;Patients;Phenotype;Population;Population Heterogeneity;postmitotic;Process;Production;Property;Proteome;Proteomics;proto-oncogene protein Spi-1;prototype;Public Health;receptor;Regulation;Regulatory Element;Reporter;Research;residence;respiratory;response;Role;Signal Transduction;Site;Stimulus;Technology;Testing;Tissues;transcription factor;transcriptome;transcriptomics;United States National Institutes of Health;Visit

PROJECT_TITLE: Regulation of Gastrointestinal Eosinophils

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(57)S]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Racial and Ethnic Minority Health Research;Sleep Research;Women's Health Research

ORG_CITY: STANFORD

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Impaired postpartum sleep can significantly impact postpartum recovery, maternal health, and the maternal- infant dyad. To characterize postpartum sleep, screen for postpartum sleep disorders and explore the association between sleep and postnatal depression, researchers and services providers need accessible, context-specific, patient-centered, psychometrically sound, and pragmatic patient-reported outcome measures (PROs) that have been developed in racially and socioeconomically diverse populations. The Patient-Reported Outcomes Measurement Information System® (PROMIS®) Sleep Disturbance and Sleep-Related Impairment PROs that will be adapted and evaluated in this proposal will meet that need, enabling postpartum sleep assessment and screening for postpartum sleep disorders in large cohorts of patients, whilst guiding future interventions to improve maternal health and well-being.

PI_NAMEs: SULTAN, PERVEZ  (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: actigraphy;antenatal;Arkansas;Asian;awake;Black race;Calibration;California;Circadian Rhythm Disorder;Clinical;Cognition;Cognitive;cohort;comorbidity;Data;design;Development;Devices;Diagnosis;Dimensions;Disease;Disparity;DSM-V;Equipment;ethnic diversity;Evaluation;experience;falls;Family Relationship;Fatigue;Feeding Patterns;Focus Groups;Future;global health;Goals;Group Meetings;Hispanic;Hospitals;Impairment;improved;Infant;Infant Development;Information Systems;Inpatients;Intervention;Interview;Link;Maternal Health;maternal wellbeing;Measurement;Measures;Mental Depression;Mental Health;Methodology;Moods;Mothers;Not Hispanic or Latino;novel;Outcome Measure;patient oriented;Patient Outcomes Assessments;patient population;Patient Self-Report;Patients;Personal Satisfaction;Physical activity;Population Heterogeneity;Postpartum Depression;postpartum health;Postpartum Period;prospective;Psychometrics;Race;racial disparity;racial diversity;Recovery;recruit;Research;Research Personnel;Restless Legs Syndrome;screening;Sensitivity and Specificity;service providers;Site;Sleep;Sleep Disorders;Sleep disturbances;Sleeplessness;socioeconomics;sound;Structure;Suicide;Surveys;Symptoms;Testing;Time;tool;United States National Institutes of Health;Validation;Woman;Work;Wrist

PROJECT_TITLE: Development and Validation of a PROMIS-based Measure to Assess Postpartum Sleep

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE The research proposed here is relevant to public health because it seeks to elucidate the biological ramifications of N7-alkylguanine and alkyl formamidopyrimidine lesions formed by various alkylating mutagens, carcinogens, and antitumor agents. Accomplishing our goal will greatly advance our understanding of the impact of these lesions on mutagenesis and cancer development.

PI_NAMEs: LEE, SEONGMIN  (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: adduct;Affect;Aflatoxin B1;Alkylating Agents;Alkylation;anomer;anti-tumor agent;Antineoplastic Agents;base;Base Excision Repairs;Base Pairing;Biochemical;Biological;Biological Assay;Bypass;Candidate Disease Gene;carcinogenesis;Carcinogens;Catalysis;Cells;Charge;Chemicals;Chemistry;Complex;Depurination;Development;Dissociation;DNA;DNA Alkylation;DNA biosynthesis;DNA Damage;DNA glycosylase;DNA Maintenance;DNA Modification Process;DNA Structure;DNA-Directed DNA Polymerase;endonuclease;enol;Equilibrium;Etiology;Excision;Fluorine;Frequencies;Genes;Genetic Transcription;genotoxicity;Goals;Guanine;Heterogeneity;Hour;Human;Imidazole;In Vitro;in vivo;Individual;Induced Mutation;innovation;insight;intercalation;ionization;Isomerism;Ketones;Kinetics;knock-down;Knowledge;Lesion;Light;Malignant Neoplasms;Mechlorethamine;Mediating;melting;Modification;Molecular Conformation;Mutagenesis;Mutagens;Mutation;mutation assay;Nicotine;Nitrosamines;Nucleosides;nucleotide metabolism;Nucleotides;Pharmaceutical Preparations;Phase;Plasmids;Polymerase;prevent;Process;programs;Property;Public Health;Publishing;Relaxation;repair model;repaired;Reporter;Reporting;Research;Role;Secondary Lesion;Site;Solid;structural biology;Structure;styrene oxide;success;synthetic construct;System;tautomer;Technology;Testing;Tobacco;tool

PROJECT_TITLE: Studies of Chemically Labile Alkylation Damage in DNA

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Clinical Research;Immunization;Infectious Diseases;Lung;Pediatric;Prevention;Vaccine Related

ORG_CITY: BATON ROUGE

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: PROJECT NARRATIVE Respiratory syncytial virus (RSV) is the number one cause of pneumonia in children under five years of age. Globally, RSV is responsible for almost 4.1 million hospitalizations and ~60,000 in-hospital deaths annually with the majority of deaths occurring in infants less than three months of age. This work will define the mechanisms responsible for protective antibody responses to RSV, which are critical to the development of safer and more effective pediatric therapeutics and vaccines against RSV.

PI_NAMEs: CORMIER, STEPHANIA A (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: 1 year old;5 year old;adaptive immunity;Address;Adult;Age;age effect;Age Months;age related;age related decline;Antibodies;Antibody Response;aspirate;Asthma;B-Cell Activation;B-Lymphocyte Subsets;B-Lymphocytes;Blood;Bronchiolitis;Cell Maturation;Cessation of life;Child;Childhood;Chronic lung disease;Clinical;cohort;Communities;Cyclophilins;Data;Dendritic Cells;Development;Disease;Failure;Formalin;Frequencies;Genetic Transcription;Hospitalization;Hospitals;Human;Immune;Immune response;Immune system;Immune Targeting;Immunoglobulin A;Immunoglobulin Class Switching;infancy;Infant;infant infection;Infant Mortality;Infection;innovation;Interferon alpha;Interferon Type I;Interferons;Interleukin-10;Investigation;Knowledge;Life;Ligands;Literature;Lower respiratory tract structure;Lymphocyte;Lymphocyte Suppression;Mediating;Membrane;Methodology;mouse model;Mucosal Immune Responses;Mucous Membrane;Mus;Neonatal;neonatal infection;neonatal mice;neonate;Nose;novel;Phenotype;Play;Pneumonia;prevent;Production;programs;Proliferating;Regulation;Research Personnel;respiratory;Respiratory Mucosa;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Respiratory Syncytial Virus Vaccines;Respiratory System;Respiratory Tract Diseases;Respiratory Tract Infections;response;Risk;Role;Sampling;Severities;Severity of illness;Signal Transduction;single-cell RNA sequencing;Structure of mucous membrane of nose;Supplementation;Therapeutic;therapy development;Time;transcriptomics;Umbilical Cord Blood;United States;Upper respiratory tract;Vaccination;Vaccine Design;vaccine development;Vaccine Therapy;Vaccinee;Vaccines;Viral Pathogenesis;Viral Respiratory Tract Infection;Virus;Virus Diseases;Work

PROJECT_TITLE: Elucidating Mechanisms of Mucosal Immune Protection Against Respiratory Syncytial Virus in Infants

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

PHR: NARRATIVE Tuberculosis (TB) is the leading cause of death from infectious disease worldwide, but can be challenging to diagnose due to the poor performance of current diagnostic tests that require sputum or tissue biopsies that can be difficult to obtain in certain patient populations, including young children, and this situation has worsened due the reallocation of healthcare resources during the COVID-19 pandemic. We thus propose to employ a novel CRISPR-based paper strip point-of-care assay to detect and quantify Mycobacterium tuberculosis-derived cell- free DNA (Mtb-cfDNA) in blood to simplify sample collection for the diagnosis and treatment evaluation of drug- sensitive and -resistent TB cases. Based on our preliminary studies, we are confident that this assay will improve TB diagnosis in all patient populations, including the diagnosis of early disease in young children, and allow consistent evaluation of Mtb-cfDNA changes that should reflect the systemic effects of anti-TB treatment, both of which are required to improve TB control efforts in resource-limited areas with high endemic TB levels.

PI_NAMEs: HU, TONY Y. (contact);TORNHEIM, JEFFREY

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: 2019-nCoV;accurate diagnosis;Address;Affect;Aftercare;Antitubercular Agents;Archives;Area;Bacillus;biobank;Biological Assay;biomedical referral center;Biopsy;Blood;Blood specimen;Body Fluids;Cause of Death;cell free DNA;Cells;Child;Circulation;Clinical;Clinical Data;clinical research site;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Communicable Diseases;COVID-19 detection;COVID-19 diagnosis;COVID-19 pandemic;Data;Detection;detection assay;detection limit;detection platform;Diagnosis;Diagnostic;diagnostic assay;Diagnostic tests;Disease;disorder control;DNA;DNA amplification;DNA analysis;Drug Evaluation;Drug resistance;Drug resistance in tuberculosis;drug-sensitive;Early Diagnosis;Equipment;Evaluation;Exhibits;Extreme drug resistant tuberculosis;Face;falls;follow-up;Genetic Recombination;Goals;Half-Life;Health Resources;Healthcare;HIV;immune function;Immune response;Immune system;improved;India;Individual;Infection;Interferon Type II;Isoniazid resistance;Laboratories;lipoarabinomannan;Longitudinal cohort study;Lung;Measures;Mediating;Methods;Modeling;Monitor;mortality;Multidrug-Resistant Tuberculosis;multiplex detection;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;novel;Paper;Pathologic;patient population;Patients;Performance;Persons;Pharmaceutical Preparations;Physiological;Plasma;point of care;point of care testing;point-of-care diagnosis;Polymerase;Population;Prediction of Response to Therapy;Predisposition;Prevalence;Prognosis;prognostic performance;Prospective cohort;Public Health;quinolone resistance;rapid diagnosis;rapid testing;Reaction;Reader;Relapse;reproductive;Resistance;Resolution;Resource-limited setting;Resources;Respiratory Disease;response;Retrospective cohort;Rifampicin resistance;RNA;sample collection;Sampling;Sensitivity and Specificity;Serum;Severities;Severity of illness;South Africa;Special Equipment;Specificity;Sputum;Testing;Time;Tissues;Treatment Efficacy;Treatment Failure;treatment response;Tuberculosis;Tuberculosis diagnosis;tuberculosis diagnostics;tuberculosis treatment;United States National Institutes of Health;Urine;Validation;Variant;viral RNA;X Inactivation

PROJECT_TITLE: Multiplexed detection of cell-free M. Tuberculosis DNA and its drug-resistant variants in blood

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Genetics;Heart Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: Tachycardia, or abnormally fast heart rate, is an independent risk factor for adverse cardiovascular events and it is known to induce or exacerbate heart failure. However, the mechanistic understanding of how increased heart rate leads to cardiac dysfunction is very limited. This proposal will capitalize on recent technological advances in stem cell biology, tissue engineering, and multi-omics to address this gap in our knowledge, thereby opening new opportunities for therapeutic interventions for relevant heart diseases.

PI_NAMEs: TU, CHENGYI  (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: 3-Dimensional;3-phosphoglycerate;Acceleration;Address;Adrenergic beta-Antagonists;Advisory Committees;Affect;analysis pipeline;Animals;Arrhythmia;Binding;Biology;Biomedical Engineering;Biopsy;Calcium;canine model;Canis familiaris;Cardiac;Cardiac Electrophysiologic Techniques;Cardiac Myocytes;cardiac tissue engineering;Cardiomyopathies;cardiovascular risk factor;Cardiovascular system;Cells;Chemicals;Coupled;CRISPR interference;Critical Pathways;Custom;Data;Data Engineering;design;Development;Enzymes;Event;experience;fatty acid metabolism;feasibility testing;Functional disorder;Future;Gene Silencing;Genes;Genetic;Glucose;Glyceraldehyde 3-Phosphate;Glyceraldehyde-3-Phosphate Dehydrogenases;Glycolysis;Goals;GTP-Binding Proteins;Heart;Heart Diseases;Heart failure;heart function;Heart Rate;Homeostasis;human data;Human Engineering;Impairment;In Vitro;induced pluripotent stem cell;Knowledge;Mass Spectrum Analysis;Mentors;Metabolic;Metabolic Diseases;metabolic profile;metabolomics;Modeling;Molecular;Morbidity - disease rate;mortality;multiple omics;Myocardial dysfunction;Myoglobin;novel;Outcome;Oxidative Stress;Pathology;Pathway interactions;Patients;Phase;Phenotype;Phosphoglycerate Kinase;Physiological;Physiology;Play;Prognosis;Protein Subunits;Proteins;Proteolysis;Qi;Recording of previous events;Recovery;Regulation;Research;Research Personnel;Risk Factors;Role;Sampling;Signal Pathway;skills;small molecule inhibitor;stem cell biology;structural heart disease;Sum;System;Tachyarrhythmias;Tachycardia;Technology;Therapeutic;Therapeutic Intervention;Tissue Engineering;Tissue Model;Training;transcriptome;transcriptome sequencing;transcriptomic profiling;transcriptomics;Treatment Failure;Validation;Ventricular Dysfunction

PROJECT_TITLE: Tachycardia-induced Metabolic Remodeling Drives Cardiac Dysfunction

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(MA)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Heart Disease - Coronary Heart Disease;Hypertension;Nutrition;Obesity;Prevention

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Obesity is a rapidly expanding epidemic that is arguably the leading cause of cardiovascular disease. Being overweight or obese increases abnormal production of the hormone aldosterone by the adrenal glands, and too much aldosterone production causes damage to the heart resulting in heart disease. This study will evaluate whether blocking the effects of aldosterone in obese individuals using a commonly available blood pressure medication can serve as an effective way to prevent heart disease in this population.

PI_NAMEs: VAIDYA, ANAND  (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: adipokines;Adrenal Glands;Adult;Aldosterone;American;antagonist;arterial stiffness;Blood Pressure;blood pressure control;blood pressure medication;Blood Vessels;Cardiac;cardiac magnetic resonance imaging;Cardiovascular Diseases;cardiovascular disorder prevention;Cardiovascular system;Cessation of life;Chlorthalidone;Clinical;clinical phenotype;Clinical Trials;Coronary;coronary fibrosis;cost effective;design;Development;Disease;Disease Outcome;Diuretics;Double-Blind Method;Enrollment;Ensure;Epidemic;eplerenone;Event;extracellular;Fatty acid glycerol esters;Fibrosis;Foundations;Future;General Population;Heart;heart disease prevention;Heart Diseases;Heart failure;heart failure with reduced ejection fraction;high risk;high risk population;Hormonal;Hormones;Hydrocortisone;Hypertension;Image;improved;Inflammation;inflammatory marker;innovation;Intervention;Leptin;Maps;Measures;Mediating;Medical;Metabolic syndrome;Methods;Mineralocorticoid Receptor;mortality;Myocardial Ischemia;Myocardial perfusion;obese patients;obese person;Obesity;Obesity associated cardiovascular disease;Outcome;Outcome Study;Overweight;Oxidative Stress;Participant;Pathogenesis;Pharmaceutical Preparations;Phenotype;Physiologic pulse;Physiological;Physiology;Population;Potassium;Potassium Chloride;predicting response;prevent;Prevention;Primary Hyperaldosteronism;Production;Prospective Studies;Protocols documentation;Public Health;public health relevance;Randomized;Receptor Activation;Renin;Research Design;Risk;Risk Factors;Severities;Stress;Stroke;Sympathetic Nervous System;targeted treatment;treatment guidelines;wasting

PROJECT_TITLE: Aldosterone, the Mineralocorticoid Receptor, and Cardiovascular Disease in Obesity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-C(02)]


ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: Project Narrative The pathogenesis of sepsis remains obscure, but is partly attributable to dys-regulated systemic inflammation propagated by “early” cytokines (e.g., TNF and IFN-γ), but sustained by “late” mediators such as high mobility group box 1 (HMGB1) and sequestosome-1 (SQSTM1). The elucidation of novel intricate mechanisms underlying the regulation of late-acting mediators will significantly improve our understanding of mechanisms underlying microbial infection-elicited dysregulated innate immune responses, and provide clues for the development of novel therapeutic strategies for the treatment of sepsis and other infectious diseases.

PI_NAMEs: WANG, HAICHAO  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: ACE2;Address;Affect;Animal Model;Antibodies;Bacteremia;Biological Markers;Blood Coagulation Disorders;Cells;Clinical;Clinical Management;Communicable Diseases;Complex;cytokine;Data;dermcidin;Development;Endotoxemia;extracellular;flexibility;Funding;Future;Grant;high risk;HMGB1 gene;Human;Immune;Immunoassay;Immunosuppression;improved;Infection;Inflammasome;Innate Immune Response;Interferon Type II;Macrophage;Mediator;microbial;Monoclonal Antibodies;National Center for Complementary and Integrative Health;National Institute of General Medical Sciences;novel;novel therapeutic intervention;Pathogenesis;Phospholipase;Proteins;receptor binding;Regulation;Research;SARS-CoV-2 spike protein;Scheme;Science;secretory protein;Seminal;Sepsis;Septic Toxemia;Serum amyloid A protein;systemic inflammatory response;TNF gene;Toxin;Treatment Efficacy;treatment strategy;Viral

PROJECT_TITLE: Mechanisms of Dysregulated Innate Immune Responses to Lethal Infections

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]