NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Hearing Loss;Pediatric;Prevention;Rehabilitation

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: PROJECT NARRATIVE Even with substantial public health advances in early identification of hearing loss and access to intervention for children who are deaf/hard-of-hearing (DHH), marked improvements in interventions to support continued language development have ceased. This study will test the effectiveness of a technology-assisted language intervention using augmentative and alternative communication software as a tool to enhance language development in children who are DHH. Expected outcomes of this study will very likely transform care delivery strategies for speech-language therapy for children who are DHH. An efficacious language intervention platform, such as the one proposed in this application, could be adapted for use among other language disordered populations providing a tremendous potential public health impact.

PI_NAMEs: MEINZEN-DERR, JAREEN  (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Academic achievement;Address;Adherence;Adult;Age;alternative communication;Area;Auditory;Augmentative and Alternative Communication;behavioral outcome;care delivery;Caregivers;Child;Child Development;childhood hearing loss;Clinical Trials Design;Cognitive;cognitive ability;Colorado;Communication;Complex;Computer software;Coupled;Data;deaf;Decision Making;design;Development;Diagnosis;Disadvantaged;Early identification;Educational process of instructing;effective therapy;Effectiveness;Effectiveness of Interventions;effectiveness testing;Emerging Technologies;evidence base;Evidence based intervention;Family;Feedback;Future;Goals;hard of hearing;hearing impairment;Home;Human;improved;improved outcome;Infant;innovation;Intervention;intervention program;Language;Language Delays;Language Development;Language Disorders;language outcome;Language Therapy;Measures;Medical center;Modeling;Monitor;multidisciplinary;National Institute on Deafness and Other Communication Disorders;Outcome;Outcome Measure;Outcome Study;Outcomes Research;Parents;Pediatric Hospitals;Population;post intervention;primary outcome;Problem behavior;programs;Psychology;Public Health;Randomized;randomized trial;Randomized, Controlled Trials;recruit;Reproducibility;Research Design;Research Support;Risk;Sampling;Semantics;Severities;Site;skills;social;Social Behavior;Social Functioning;Speech;standard care;Standardization;Strategic Planning;syntax;Techniques;Technology;Testing;tool;treatment as usual;Visual;Work

PROJECT_TITLE: Technology-assisted language intervention for children who are deaf/hard-of-hearing (TALI)

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PI_NAMEs: HACOHEN, NIR  (contact)

PROJECT_TERMS: Address;Affect;Animal Disease Models;Animal Model;Anti-Inflammatory Agents;Antigen-Antibody Complex;Apoptotic;Autoimmune;Autoimmunity;Automobile Driving;B-Cell Activation;B-Lymphocytes;Cell Communication;Cell Physiology;cell type;Cells;Clinical;Coculture Techniques;cohort;cytokine;Cytotoxic T-Lymphocytes;Data;DIF factor;differential expression;Dimensions;Disease;Educational process of instructing;Endothelium;Environmental Risk Factor;exhaustion;experimental study;Extravasation;FCGR3B gene;Fibroblasts;Generations;Genes;genetic association;Genetic Risk;Genetic study;genetic variant;genome wide association study;high dimensionality;Human;human tissue;Image;Image Analysis;imaging study;Immune;Immune response;Immunology;In Vitro;Infiltration;Inflammation;Inflammatory;Kidney;kidney cell;Lesion;Link;Location;Lupus;Lupus Nephritis;Lymphocyte;Maps;Measures;Methods;Microscopy;Monitor;monocyte;Necrosis;novel;Nucleic Acids;overexpression;Pathologic;Pathology;Pathway interactions;patient stratification;Patients;Phagocytosis;Physiological;programs;Reagent;Regulation;repaired;Resolution;risk variant;RNA;Role;Sampling;Signal Transduction;single-cell RNA sequencing;Stains;Structure;System;Systemic Lupus Erythematosus;T-Cell Activation;Testing;tissue repair;Tissues;Transcript;transcription factor;transcriptome sequencing;Virulence Factors;Visualization;Work

PROJECT_TITLE: Regulation, function and localization of monocytes in autoimmune tissues


ADMINISTERING_IC: HS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: HYATTSVILLE

ORG_NAME: MEDSTAR HEALTH RESEARCH INSTITUTE

ORG_STATE: MD

PHR: PROJECT NARRATIVE Safety assessment of electronic health records focuses on adult populations, even though challenges with health information technology contribute to a large portion of errors in pediatric populations, specifically medication errors in pediatric weight-based dosing. Our proposal will engage subject matter experts in pediatrics, medication safety, and informatics to optimize a tool to assess pediatric medication safety, test this tool across at least 20 hospitals, and measure the impact of changes made as a result of the assessment system on medication safety. The assessment tool can be applied across diverse healthcare settings as a robust, low-cost method of assessing and optimizing pediatric medication safety.

PI_NAMEs: KAZI, SADAF  (contact);MUTHU, NAVEEN

PROGRAM_OFFICER_NAME: SAMAD, FARZANA

PROJECT_TITLE: A Systems Engineering Approach to Optimize Pediatric Medication Safety

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Pediatric

ORG_CITY: CHAPEL HILL

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Non-polio human enteroviruses (NPEVs) represent an existing and emerging threat to public health, especially to infants and children. With more than 100 NPEVs known and the high rate of mutation and recombination of these viruses, the risk for evolution of virulent strains is high. Because we cannot predict the serotype of any newly emerging strain, addressing this problem effectively will require pan-enterovirus solutions. The central objective of this application is to establish unifying models for the biological functions of the enterovirus 2C protein that will provide a framework to establish 2C as a pan-enterovirus therapeutic target.

PI_NAMEs: CAMERON, CRAIG E. (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Address;ATP phosphohydrolase;Biochemical;Biological;Biological Models;Biological Process;biophysical properties;biophysical techniques;Cell model;Cells;Chemicals;Child;Chimeric Proteins;Code;Collaborations;Coxsackie Viruses;Cytoplasm;Data;Dependence;design;Development;dimer;Drug resistance;Electron Microscopy;Enterovirus;Enterovirus 68;Enterovirus 71;Enzymes;Evolution;Exhibits;fitness;Fluorescence Microscopy;Genetic Recombination;Genome;graduate student;Guanidines;Hela Cells;helicase;Human;Human poliovirus;Hydantoins;Infant;Infection;inhibitor;Institution;Kinetics;Laboratories;Length;lipidome;Lipids;Location;Mass Spectrum Analysis;Mediating;member;Membrane;Modeling;Molecular Target;Mutation;Nucleotides;pan-enterovirus;physical property;Proteins;Public Health;Publishing;Reporting;Resistance;Risk;RNA;RNA-Directed RNA Polymerase;Role;Scanning;Serotyping;Site;Solubility;Specificity;Structure;therapeutic target;Transmission Electron Microscopy;Tumor Cell Line;Vesicle;viral fitness;viral RNA;Virion;Virulent;Virus;Virus Diseases

PROJECT_TITLE: Enteroviral 2C protein as a therapeutic target


ADMINISTERING_IC: MH

ED_INST_TYPE: SCH OF BUSINESS/PUBLIC ADMIN

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Bioengineering;Brain Disorders;Data Science;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Telehealth

ORG_CITY: TUCSON

ORG_DEPT: ADMINISTRATION

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative Autism spectrum disorder (ASD) is a neurobiological condition with increasing prevalence for which early diagnosis is crucial but unfortunately often late or missed entirely, in large part due to lack of trained clinicians. This project will create health information technology (HIT) that uses natural language processing and machine learning algorithms with electronic health records to support non-expert clinicians in identifying children at risk for ASD. The HIT will be evaluated with non-expert clinicians for the minimum and optimal requirements to help clinicians make confident and high quality decisions.

PI_NAMEs: LEROY, GONDY  (contact)

PROGRAM_OFFICER_NAME: LUSHIN, VICTOR

PROJECT_TERMS: 8 year old;Address;adult with autism spectrum disorder;Affect;Age;algorithmic bias;Algorithms;Autism Diagnosis;autism spectrum disorder;Awareness;Behavior;Behavioral;behavioral phenotyping;Belief;blind;Caring;Centers for Disease Control and Prevention (U.S.);Child;Classification;Clinic;Clinical;Data;Decision Making;deep learning;Development;Developmental Disabilities;developmental disease;Diagnosis;Diagnostic and Statistical Manual of Mental Disorders;diagnostic criteria;Disease;disorder risk;Early Diagnosis;Early identification;Early Intervention;Early treatment;economic cost;Education;Electronic Health Record;electronic structure;Evaluation;experience;Goals;health information technology;high risk;Hospitals;Human;human-in-the-loop;improved;improved outcome;Individual;Intuition;Label;large datasets;Machine Learning;machine learning algorithm;machine learning model;Medical;Medical Education;Modeling;Monitor;Natural Language Processing;Neurobiology;Outcome;Pattern;Performance;Physicians;Prevalence;Productivity;prototype;randomized trial;Records;Resources;Risk;Risk Assessment;SET Domain;social;Specialist;Structure;structured data;Techniques;Testing;Text;tool;Training;unstructured data;Update;Use of New Techniques;Vocabulary;Work

PROJECT_TITLE: Health Information Technology to Support Autism Spectrum Disorders (ASD) Risk Assessment for Early Diagnosis

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Kidney Disease;Lupus;Rheumatoid Arthritis

PHR: Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are two diseases that affect the joints and the kidneys. In both diseases, the immune system goes awry and causes chronic inflammation that damages the tissues. We are determining what drives the abnormal cells and their interactions with other cells in order to find new ways to target treatments for RA and lupus nephritis.

PI_NAMEs: BRENNER, MICHAEL B. (contact)

PROJECT_TERMS: Abnormal Cell;Acceleration;Affect;Anatomy;Automobile Driving;B-Lymphocytes;Blood Vessels;cell type;Cells;Characteristics;chemokine;Chronic;chronic inflammatory disease;cytokine;Cytokine Activation;Data;Degenerative polyarthritis;Development;Discriminant Analysis;Disease;Endothelium;experimental study;Fibroblasts;Fibrosis;Flow Cytometry;Gene Expression;Genetic Transcription;HLA-DR Antigens;human tissue;Image;Immune;Immune system;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Arthritis;insight;Interferon alpha;Interferon Type II;Interferons;Interleukin-1 beta;Interleukin-6;Joints;Kidney;Knowledge;leukocyte activation;Leukocytes;Ligands;Location;Lupus;Lupus Nephritis;lymph nodes;Lymphoid Tissue;Macrophage;Mediating;Medicine;mouse model;Nephritis;notch protein;NOTCH3 gene;novel strategies;Organ;Organoids;Pathology;Pattern;Peripheral;Play;Population;prevent;Production;recruit;Rheumatoid Arthritis;Role;Signal Transduction;single-cell RNA sequencing;Stromal Cells;Synovial Membrane;System;Systemic Lupus Erythematosus;T-Lymphocyte;targeted treatment;Testing;Tissues;TNF gene;transcriptome sequencing;transcriptomics

PROJECT_TITLE: Role of fibroblastic stromal cells and notch signaling in tissue inflammation in RA and SLE


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Hypertension;Neurosciences;Sleep Research

ORG_CITY: PORTLAND

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Hypertension is a public health epidemic, and in >30% of people with hypertension, blood pressure does not adequately fall during the night compared to daytime values (i.e., non-dipping). This non-dipping hypertension dramatically increases the risk for cardiovascular disease and increases the likelihood of early death, yet the mechanisms underlying this phenomenon are unclear. Through a mechanistic clinical trial, we will determine the individual contributions of sleep and the circadian system to non-dipping blood pressure to further behavioral and circadian time-based treatment of this syndrome.

PI_NAMEs: THOSAR, SAURABH SUHAS (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Address;Adult;adverse outcome;Affect;Aldosterone;Anti-Hypertensive Agents;Attenuated;Autonomic nervous system;Beds;Behavior;Behavior Therapy;Behavioral;Biological;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure reduction;blood pressure variability;Cardiac;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Categories;Cessation of life;Chronotherapy;circadian;Circadian Rhythms;Classification;Clinical;Clinical Trials;Cross-Over Trials;Crossover Design;Cues;Data;design;Drops;Epidemic;Equilibrium;Event;evidence base;experimental study;falls;Female;Future;Goals;Guidelines;Health Expenditures;Home;Hour;Hypertension;hypertensive;IGFBP2 gene;improved;Individual;Laboratories;Laboratory Study;Light;male;Measures;Minor;Monitor;Morbidity - disease rate;mortality;new therapeutic target;normotensive;Organ;Outcome;Participant;Patients;Pattern;Persons;Pharmaceutical Preparations;pharmacologic;pilot test;Polysomnography;poor sleep;Posture;Protocols documentation;Public Health;Randomized;Recommendation;Renin-Angiotensin-Aldosterone System;Research;Rest;Risk;Risk Factors;Role;Schedule;side effect;Sleep;Sleep Disorders;sleep onset;sleep pattern;Standardization;Syndrome;System;Testing;Time;United States;Variant;Vascular Endothelium;Wakefulness;Work

PROJECT_TITLE: Sleep and circadian mechanisms in hypertension

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Inflammatory Bowel Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Wound Healing and Care

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Inflammatory bowel disease represents a collection of medically incurable illnesses that cause severe and chronic damage to the lining of the bowel. Although all available therapies for IBD target the overactive immune system, promotion of healing of the damaged bowel through regenerative medicine represents a promising complementary strategy. Here, we elucidate important aspects of a noncanonical colonic wound healing response that originates from the neighboring skin-like anal transition zone and which could yield therapeutic insights.

PI_NAMEs: LIU, CAMBRIAN YANGSHAO (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Ablation;Acute;Anatomy;Anus;Biological Assay;cancer initiation;cancer risk;Cell Therapy;cell type;Cells;Chronic;clinical translation;Colitis;Collection;Colon;Colon Injury;colonic crypt;confocal imaging;crypt cell;Development;Disease Outcome;Distal;Dyes;Epithelial Cells;epithelial stem cell;epithelial wound;Epithelium;epithelium regeneration;Genetic Transcription;Goals;Growth;healing;Human;Hybrids;imaging study;Immune response;Immune system;Inflammatory;Inflammatory Bowel Diseases;insight;intestinal crypt;Intestines;Investigation;Knowledge;Location;Measures;Mediating;Medical;Mesenchymal;Mesenchyme;Metaplasia;migration;Modeling;Molecular;Mucous Membrane;Multimodal Imaging;Mus;Natural regeneration;new therapeutic target;novel;Oncogenic;Organoids;Outcome;Pathway interactions;Patients;Penetration;Phenotype;Population;Process;programs;re-epithelialization;Reagent;rectal mucosa;regeneration potential;regenerative cell;Regenerative Medicine;Regenerative research;Regenerative response;regenerative therapy;Relative Risks;repaired;Research;Research Project Grants;Resistance;response;Risk;Role;Signal Pathway;Signal Transduction;Skin;Source;Specimen;stem;stem cell population;stem cells;Structure;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Therapeutic Uses;Tissues;transcription factor;transcriptomics;Transitional Cell;translational potential;Transplantation;tumor;tumorigenesis;Ulcer;Work;wound healing

PROJECT_TITLE: Colonic epithelial wound healing by anal transitional cells

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: HD

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: LOGAN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UTAH STATE UNIVERSITY

ORG_STATE: UT

PHR: Project Narrative (Relevance to Public Health) There is increasing evidence that dietary factors and resulting metabolic status in fathers program metabolic health in their children by currently unidentified epigenetic mechanism. This project works towards identification of a molecular mechanism that connects diet and metabolic health of fathers with their sperm epigenome and resulting offspring physiology.

PI_NAMEs: MEYER-FICCA, MIRELLA L (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Acetyl Coenzyme A;Acetylation;Address;Adipose tissue;Affect;age acceleration;Antibodies;Birth;Body Size;carbohydrate metabolism;Carbohydrates;Cells;Child;Chromatin;chromatin immunoprecipitation;chromatin modification;chromatin remodeling;Conceptions;Data;Development;Diet;dietary;Dietary Factors;differential expression;DNA Methylation;Energy Metabolism;Environmental Exposure;Enzymes;Epigenetic Process;epigenome;Exhibits;Fathers;Fatty acid glycerol esters;Fertility;Future;Gene Expression;Gene Expression Profile;Genes;genetic risk factor;genomic locus;Glucose;Goals;Growth;Health;Heritability;High-Throughput DNA Sequencing;Histone Acetylation;histone acetyltransferase;Histone Deacetylase;Histone H4;histone modification;Histones;Human;Infertility;Inherited;innovation;insight;insulin sensitivity;Intake;interest;Intervention;Laboratory Animals;lean body mass;Link;lipid metabolism;Liver;male;Mediating;men;Metabolic;Metabolic Diseases;Metabolism;Micronutrients;Modeling;Modification;Molecular;mouse model;Mus;NADP;National Institute of Child Health and Human Development;Nature;Niacinamide;Nicotinamide adenine dinucleotide;Nicotinic Acids;nutrition;Nutritional status;nutritional supplementation;obesity in children;offspring;Oxygen Consumption;pharmacologic;Phenotype;Physical activity;Physiology;Poly(ADP-ribose) Polymerases;Population;Positioning Attribute;prevent;programs;Public Health;Pyruvate;Regulation;Reporting;Research;Respiration;respiratory;Role;sensor;Sirtuins;sperm cell;Spermatogenesis;Strategic Planning;Supplementation;Testing;Time;Transgenic Mice;Work

PROJECT_TITLE: Molecular sensors for metabolic programming of the sperm epigenome and offspring physiology

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW YORK

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative  Bestrophins are a family of ion channels with critical (patho)physiological roles in the eye, as mutations of bestrophin-1 (Best1) cause retinal degenerative disorders, while bestrophin-2 (Best2) regulates intra-ocular pressure. This project is aimed to identify interacting protein partners of bestrophins and elucidate the structural and functional consequences of these interactions. The findings from this work will provide important knowledge on ocular physiology, and establish a versatile platform for investigating other ion channels of interest and their interacting partners.

PI_NAMEs: YANG, TINGTING  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Anions;Aqueous Humor;Bacteria;Biological;biophysical analysis;Calcium Signaling;cell growth regulation;Cell Reprogramming;Cells;Ciliary Body;Ciliary epithelium;CRISPR/Cas technology;Cryoelectron Microscopy;Degenerative Disorder;Drainage procedure;Electrophysiology (science);Epithelium;Eye;Eye diseases;Family;Genes;genome editing;Goals;Human;interest;Ion Channel;Ion Transport;Knock-out;Knowledge;Light;Link;Mammals;Mass Spectrum Analysis;Mediating;Membrane Proteins;multidisciplinary;Mus;Mutation;Names;Ocular Hypertension;Ocular Physiology;Open-Angle Glaucoma;Pharmacologic Substance;Physiologic Intraocular Pressure;Physiological;Play;protein complex;protein structure;Proteins;Regulation;Reporting;Research;response;Retina;Retinal Degeneration;Risk Factors;Role;Signal Transduction;stem cells;Structure of retinal pigment epithelium;Tissues;Vision;Work

PROJECT_TITLE: Interacting Partners of Bestrophin Channels

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Obesity;Patient Safety;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The goal of this innovative proposal is to bring together a policy-level strategy and adaptive implementation to develop and validate practical, effective and scalable strategies to achieve clinical practice change. Specifically, this project will have an important clinical impact by improving adherence to preoperative patient optimization across a statewide health system and will inform novel implementation strategies that could be scaled to other important clinical practice gaps. Optimally combining practice change strategies will allow for a tailored and cost-effective approach to improve the quality and cost of care.

PI_NAMEs: TELEM, DANA ALEXA (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: abdominal wall;Adherence;adherence rate;Adopted;Award;behavior change;Blood Glucose;care costs;Case Study;Cessation of life;Clinical;clinical practice;compare effectiveness;cost effective;Day Surgery;design;Diabetes Mellitus;Education;effectiveness evaluation;effectiveness testing;Ensure;Evaluation;evidence base;evidence based guidelines;financial incentive;Goals;Guideline Adherence;Guidelines;Health system;Healthcare;Hernia;Hernia of abdominal cavity;high risk;hospital performance;Hospitals;implementation cost;implementation science;implementation strategy;improved;improved outcome;Incentives;Individual;innovation;Interruption;Intervention;intervention cost;Knowledge;Maps;Measures;Methods;Michigan;Modeling;Morbid Obesity;Morbidity - disease rate;Natural experiment;novel;obesity management;Operative Surgical Procedures;Organizational Change;Organizational Culture;Patients;Pattern;payment;Performance;Persons;Physicians;Policies;Policy Analysis;Population;Practice Management;primary outcome;Principal Investigator;programs;Provider;provider behavior;Randomized;Registries;remediation;repaired;Research;Resource Allocation;Resources;response;secondary outcome;Sequential Multiple Assignment Randomized Trial;Services;Site;Smoking;smoking cessation;Surgeon;Surgical complication;surgical risk;System;Testing;Theoretical Domains framework;Time Series Analysis;tool;trial design;United States Agency for Healthcare Research and Quality;Work;Writing

PROJECT_TITLE: Combining Policy and Implementation Science to Optimize Clinical Practice

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Hematology

ORG_CITY: LEXINGTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Platelets detect vessel damage and secrete granule cargo to form clots. They also detect pathogens, via endocytosis, and process them to alert the immune system. Understanding how platelets do these things will lead to a better understanding of thrombotic disease.

PI_NAMEs: WHITEHEART, SIDNEY WALDO (contact)

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affect;Area;Blood Platelets;Blood Vessels;Cell Physiology;Cellular biology;Cessation of life;Chronic;Coagulation Process;Cytoplasmic Granules;Data;Detection;Endocytosis;Exocytosis;Growth;Hemostatic function;HIV-1;holistic approach;human disease;Immune response;Immune system;Immunity;Innate Immune Response;innovation;insight;Knowledge;Link;Membrane;Modeling;Molecular;Mouse Strains;Natural Immunity;pathogen;Pathogen detection;Pathway interactions;Physiological;Process;programs;Publications;Reagent;Research;Risk;Role;Signal Transduction;Sorting;Technology;Therapeutic;Thrombosis;Thrombus;tool;trafficking;Transgenic Mice;Viremia;Virus;Work

PROJECT_TITLE: Platelet Exocytosis and Endocytosis in Thrombosis and Immunity


ADMINISTERING_IC: DC

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: Newark

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Project Narrative This project seeks to develop a microengineered tissue model of the human vocal fold using pluripotent/ multipotent stem cells, custom-designed synthetic matrices and a multicompartment microfluidic device with integrated strain sensors. Using the microfluidic vocal fold tissue model, we will investigate how damage to the epithelium initiates fibrosis and how the fibrotic microenvironment sustains scarring. The chip-based vocal fold scar model will be utilized to evaluate the therapeutic efficacy of antifibrotic remedies.

PI_NAMEs: JIA, XINQIAO  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acoustics;Adopted;Affect;Aging;Air;Air Movements;American;Animal Model;Apoptosis;Architecture;Basement membrane;Biochemical;Biology;Biomechanics;Biophysics;Calibration;Cell model;Cells;Cellular Morphology;Chemical Exposure;Chemicals;Cicatrix;Clinical;Communities;Connective Tissue;Consensus;Cues;Custom;cytokine;Data;Decision Making;Deposition;design;Development;Disease;efficacious treatment;Elasticity;Engineering;Epithelial Cells;epithelial injury;Epithelium;Extracellular Matrix;fasudil;FGF2 gene;Fibroblasts;fibrogenesis;Fibrosis;Functional disorder;fundamental research;FUS-1 Protein;Future;Gene Expression;graphene;Growth Factor;healing;Health;Human;human tissue;Hydrogels;improved;In Situ;In Vitro;induced pluripotent stem cell;inhibitor;interfacial;interstitial;Intervention;Lamina Propria;Larynx;Ligation;Lung;mechanical properties;Mechanical Stress;Mechanics;Mesenchymal;Mesenchymal Stem Cells;Methodology;Methods;Microfluidic Microchips;Microfluidics;mimetics;miniaturize;Modeling;Molecular;Monitor;Motion;Multipotent Stem Cells;Muscle;Myofibroblast;Operative Surgical Procedures;Organ;Parents;Pathologic;Permeability;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phenotype;Phonation;Physiological;Physiology;Pliability;Predisposition;prevent;Process;Proliferating;Property;Protein Kinase;re-epithelialization;real time monitoring;repaired;Research;rho;sensor;Side;Signal Transduction;sound;spatiotemporal;Stratified Epithelium;Stratified Squamous Epithelium;Stream;Structure;Testing;TGFB1 gene;Therapeutic;Tissue Engineering;tissue injury;Tissue Microarray;Tissue Model;Tissues;Trachea;Treatment Efficacy;vocal cord;vocalis muscle;Voice;wound healing

PROJECT_TITLE: A Hydrogel-Based Cellular Model of the Human Vocal Fold

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Genetics;Hematology;Infectious Diseases;Lung;Rare Diseases;Sepsis

ORG_CITY: Columbus

ORG_DEPT: PHYSIOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Lung microvascular endothelial dysfunction is a hallmark of acute lung injury and sepsis. The proposed studies will be the first to elucidate a new post-translational modification of NF-ĸBp65, ISGylation, and its inhibitory role in of NF-ĸB activation and lung endothelial inflammation. These studies will be critical in development of novel therapeutics by stabilization of ISG15 E3 ligase to diminish lung microvascular endothelial dysfunction in acute lung injury and sepsis.

PI_NAMEs: ZHAO, YUTONG  (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Acute Lung Injury;Acute Respiratory Distress Syndrome;Anti-Inflammatory Agents;attenuation;Cell Adhesion Molecules;Cell Physiology;chemokine;Data;Development;Disease;Endothelial Cells;Endothelium;Exhibits;F-Box Proteins;Family member;Foundations;Functional disorder;Genes;Genetic Transcription;Human;IL8 gene;Immune response;Inflammation;Inflammatory;Intercellular adhesion molecule 1;Interferons;Interleukin-6;isopeptidase;Ligase;Lung;lung injury;lung microvascular endothelial cells;Mediating;Modification;Molecular;mouse model;neutrophil;NF-kappa B;novel therapeutics;Nuclear;overexpression;p65;Pathogenesis;Pathologic;Pathway interactions;Phosphoric Monoester Hydrolases;Phosphorylation;Play;Post-Translational Protein Processing;Process;Property;Proteins;Regulation;Reporting;response;Rest;Role;Scheme;Sepsis;sepsis induced ARDS;Serine;Severities;side effect;Site;small molecule;small molecule inhibitor;Stimulus;Structure of parenchyma of lung;transcription factor;Transcriptional Activation;Transgenic Mice;Ubiquitin Like Proteins;ubiquitin-protein ligase;Up-Regulation;vascular endothelial dysfunction;Vascular Endothelium

PROJECT_TITLE: ISGylation regulates lung endothelial inflammation

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Contraception/Reproduction;Estrogen;HIV/AIDS;Infectious Diseases;Prevention;Women's Health Research

ORG_CITY: RONDEBOSCH

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF CAPE TOWN

PHR: Observational clinical data suggest that the injectable contraceptive depo-medroxyprogesterone acetate (DMPA- IM) increases HIV-1 acquisition risk by 32-40% compared to another injectable contraceptive norethisterone enanthate (NET-EN). Our proposed study comparing immune biomarkers and peak serum progestin and endogenous hormone levels relevant to HIV-1 infection in archived samples from a clinical trial of women randomized to DMPA-IM and NET-EN, and comparable in vitro mechanism studies, will provide high quality evidence of plausible mechanisms as to whether these two injectable contraceptives are likely to have different effects on HIV-1 risk. Insights from this study will be relevant to clinical practice and public health, particularly in South Africa, regarding choice of injectable contraception in areas at high risk for HIV-1 acquisition, where DMPA-IM and NET-EN are used without discrimination, and may also impact on international guidelines to either reassure interchangeable use or suggest preferential use of one of these injectable contraceptives over the other in populations at high risk of HIV-1 infection.

PI_NAMEs: CHEN, PAI-LIEN ;HAPGOOD, JANET PATRICIA (contact)

PROGRAM_OFFICER_NAME: SHARMA, USHA K

PROJECT_TERMS: Address;Affect;Africa South of the Sahara;aged;androgenic;Androgens;Area;Behavioral;Biological;Biological Markers;Biometry;black women;Blood specimen;CCR5 gene;Cell model;Cell Separation;Cells;Clinical;Clinical Data;clinical practice;Clinical Trials;Contraceptive Agents;contraceptive efficacy;Contraceptive methods;Data;Development;Disadvantaged;Discrimination;Dose;Enzymes;Epidemic;Epidemiology;estrogenic;Estrogens;Exhibits;Genes;Glucocorticoid Receptor;Guidelines;head-to-head comparison;Health;Health Policy;Heptanoates;High Prevalence;high risk;high risk population;HIV-1;Horizontal Disease Transmission;hormonal contraception;Hormones;Immune;immune function;Immune Targeting;Immunologic Markers;Immunology;Implant;In Vitro;in vivo;Individual;Infection;infection rate;Injectable;Injections;insight;inter-individual variation;Interdisciplinary Study;International;Intramuscular;Intramuscular Injections;Investigation;Knowledge;Levonorgestrel;Measures;Medroxyprogesterone 17-Acetate;Norethindrone;novel;Observational Study;Pathogenesis;peptide hormone;Population;Predisposition;Progestins;Proteins;Public Health;Randomized;randomized trial;receptor;Regulation;Relative Risks;reproductive tract;Research;Research Personnel;response;Risk;sample archive;Sampling;Series;Serum;Sex Bias;sexually active;side effect;South Africa;South African;steroid hormone;steroid metabolism;Steroid Receptors;Steroids;Technology;Time;Tissue Model;Vertical Transmission;Woman;women's clinical trial;Women's Health;young woman

PROJECT_TITLE: Biological effects, hormone levels and mechanisms relevant to HIV-1 infection for women randomized to the injectable contraceptives depo-medroxyprogesterone acetate or norethisterone enanthate.


ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Narrative Chronic hypertension and aortic stenosis increase the contractile demands on the heart resulting in progression to heart failure. The precise mechanisms by which chronic elevated cardiac stress leads to heart failure are not known, and therefore, there are no effective treatments for patients with this condition. We have identified a cardiac regulatory protein (MyBPC) that modulates the cardiac contractile response to chronic stress. Thus, in this proposal we will investigate how manipulating MyBPC function can improve cardiac function in hypertension to prevent progression to heart failure.

PI_NAMEs: STELZER, JULIAN  (contact)

PROJECT_TERMS: Ablation;absorption;Address;Aging;aging mechanism;American;Animal Model;Aortic Valve Stenosis;Biological Availability;blood pressure reduction;Bypass;Cardiac;cardioprotection;cardiovascular risk factor;Cardiovascular system;cGMP-dependent protein kinase I;Chronic;Chronic stress;Clinical;Clinical Trials;Complex;Conscious;conventional therapy;Cyclic AMP-Dependent Protein Kinases;Cyclic GMP-Dependent Protein Kinases;Death Rate;Dependovirus;design;Development;Disease;Economic Burden;effective therapy;EFRAC;Experimental Models;Failure;Foundations;Functional disorder;Gene Delivery;Gene Transfer;Generations;genetic regulatory protein;Genetically Engineered Mouse;Genomics;health economics;Heart;Heart failure;heart function;human old age (65+);Hypertension;hypertensive;Impairment;improved;improved outcome;In Vitro;in vivo;Incidence;Individual;Kidney;kidney dysfunction;Left;Left Ventricular Dysfunction;Measurement;Measures;Medical;mimetics;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;Muscle;Mutation;Myocardial dysfunction;Myocardium;Nephrons;new therapeutic target;Nitric Oxide;normotensive;novel;novel therapeutic intervention;novel therapeutics;old mice;older patient;Older Population;Organ;Outcome;Oxidative Stress;Pathologic;Patients;Phenotype;Phosphorylation;preservation;pressure;Prevalence;prevent;Prevention;Prognosis;Property;Reactive Oxygen Species;Regulation;Relaxation;renal damage;Renal function;Resistance;response;Risk;Risk Factors;Serine;side effect;Signal Pathway;Signal Transduction;socioeconomics;Sodium;Stress;success;systemic inflammatory response;Testing;therapy development;tool;Transgenic Animals;Transgenic Mice;translational study;United States;Ventricular;Ventricular Remodeling;viral gene delivery

PROJECT_TITLE: Novel downstream effectors of protein kinase G in hypertensive disease

STUDY_SECTION: HM

STUDY_SECTION_NAME: Hypertension and Microcirculation Study Section[HM]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Congenital Heart Disease;Congenital Muscular Dystrophy;Congenital Structural Anomalies;Genetics;Heart Disease;Intellectual and Developmental Disabilities (IDD);Muscular Dystrophy;Pediatric;Rare Diseases

ORG_CITY: KENNESAW

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: KENNESAW STATE UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Heart and/or skeletal muscle defects in newborn infants remain the most prevalent form of human birth defects, yet the exact genes and genetic processes that can either positively or negatively affect muscle development remain unknown. Studies on Akirin, a nuclear protein that is found in both fruit flies and humans, have indicated that Akirin works with a novel class of regulators to facilitate heart and skeletal muscle development By studying the role of Akirin during this process in fruit fly embryos, we will learn how this protein likely functions in vertebrates, such as mammals, during heart formation.

PI_NAMEs: NOWAK, SCOTT JAMES (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Affect;Alleles;Authorship;Award;Biochemical;Biological Assay;Birth;Candidate Disease Gene;Cardiac;cardiogenesis;Cells;chromatin remodeling;Chromatin Remodeling Factor;cofactor;Complement;Conceptions;Congenital Abnormality;congenital heart abnormality;Congenital Heart Defects;congenital muscular dystrophy;Data;Defect;Development;Developmental Process;Disease;Drosophila genus;Embryo;Embryonic Development;Embryonic Heart;Enhancers;Ethnic Population;experience;experimental study;Family member;Fetal health;Fluorescence;Frustration;Future;GATA4 gene;Gene Activation;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Processes;Genetic Techniques;Genetic Transcription;genomic locus;geographic population;Goals;Heart;heart defect;heart function;Heterozygote;Histologic;Human;Imaging Techniques;in vivo;Incidence;Information Dissemination;innovation;Insecta;insight;Laboratories;Learning;Live Birth;Mammals;Manuscripts;Mediating;member;Mesoderm;Messenger RNA;Microscopic;Molecular;Muscle;Muscle Development;Muscular Dystrophies;mutant;Myocardium;myogenesis;Myopathy;Nature;Newborn Infant;novel;Nuclear Protein;Pathway interactions;Pattern;Peer Review;Personal Satisfaction;Phenotype;Physiological;Play;Population;Prevention;Process;Proteins;recruit;Reporter;Research;Research Activity;Research Personnel;Research Support;Role;skeletal;Skeletal Muscle;Specific qualifier value;Structure;symposium;Talents;Techniques;transcription factor;undergraduate student;United States National Institutes of Health;Vertebrates;Work;Zinc Fingers

PROJECT_TITLE: The role Akirin and Pannier interactions during myogenesis


NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Recent genetic studies have identified a large compendium of genes associated with protein-truncating mutations in autism spectrum disorder (ASD), and these studies have demonstrated overwhelming support for chromatin modification and synaptic function as key pathways involved in ASD pathogenesis. Here, we seek to understand how these pathways converge on synaptic changes that contribute to neurodevelopmental deficits and will use a massively parallel CRISPR-engineering approach to disrupt 48 genes against the same genetic background and characterize the gene expression and functional changes that occur in human induced pluripotent stem cell derived neurons. These studies identify new mechanisms by which genes contribute to ASD and provide an invaluable resource of isogenic stem cell models of ASD to the broader research community.

PI_NAMEs: BRENNAND, KRISTEN JENNIFER (contact);RUDERFER, DOUGLAS ;TALKOWSKI, MICHAEL E

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: 16p11.2;Alleles;autism spectrum disorder;Autopsy;Biological;Biological Assay;Biology;cell type;chromatin modification;chromatin remodeling;Chromatin Remodeling Factor;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;Communities;Complex;Data;data integration;Data Set;Development;Disease;disorder risk;Disparate;druggable target;Electronic Health Record;Engineering;Etiology;Evaluation;Female;fetal;gene discovery;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic study;Genetic Transcription;Genetic Variation;genome-wide;Genomics;Glutamates;Goals;Heterozygote;human induced pluripotent stem cells;improved;in silico;Individual;Induced pluripotent stem cell derived human neuron;innovation;insight;Link;loss of function;loss of function mutation;male;Methods;model of autism spectrum disorder;Modeling;Mutation;National Institute of Mental Health;neurodevelopment;Neurodevelopmental Deficit;Neurodevelopmental Disorder;Neurons;neuropsychiatric disorder;novel;Outcome;parallelization;Pathogenesis;Pathway interactions;Phenotype;postnatal;Predisposition;Process;Protein Truncation;Proteins;Relative Risks;Research;Resources;Risk;Risk Factors;risk variant;Sampling;Series;stem cell model;Synapses;synaptic function;Testing;therapeutic target;Transcriptional Regulation;transcriptome;transcriptome sequencing;transcriptomics

PROJECT_TITLE: Functional convergence following disruption of diverse genes associated with neurodevelopmental disorders

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Bioengineering;Digestive Diseases;Liver Disease;Regenerative Medicine

ORG_CITY: CORAL GABLES

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative My research program aims to understand the molecular mechanisms by which biomechanical forces control tissue regeneration and fibrosis upon organ injury. I expect this research program will advance therapeutic strategies for organ fibrosis and other diseases with aberrant tissue mechanics via providing precise targets in cellular mechanotransduction pathways.

PI_NAMEs: MENG, ZHIPENG  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Biochemical;Biomechanics;Biomedical Engineering;Cardiovascular Diseases;cell growth;Cell membrane;Cell Physiology;Cells;Choristoma;Cues;Development;Disease;Disease Progression;Endothelial Cells;Endothelium;Fibroblasts;Fibrosis;Genetic Transcription;Growth;Homeostasis;Human;human disease;In Vitro;in vivo;Knowledge;Liver;Liver Fibrosis;liver injury;Liver Regeneration;lung regeneration;Malignant Neoplasms;Mechanics;mechanotransduction;Modeling;Molecular;mouse model;Natural regeneration;new therapeutic target;Organ;organ injury;organ regeneration;organ repair;Output;Pathway interactions;Play;Process;programs;Pulmonary Fibrosis;Research;Role;Signal Transduction;Study models;Therapeutic;tissue regeneration;tissue repair;transcriptome;wound healing

PROJECT_TITLE: Roles of mechanotransduction in organ regeneration and fibrosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ORG_NAME: SINAI HEALTH SYSTEM, INC.

PHR: Program Narrative Unlike a randomized control trial, our design seeks to draw causal inferences about the impact of varying the sequence of three TBC enhancements: small-group diabetes self- management training (DSMT), technology-supported remote glucose monitoring (RGM), and high-touch, individualized community health worker (CHW) support. Having better knowledge of how enhancements operate and their individual and combined impact on diabetes outcomes for people with a greater risk for poor diabetes control, is vital in ensuring limited resources are applied in ways that enhance efficiency, reduce costs, and improve patient outcomes and patient/provider experience. Second, the proposed study will examine the appropriateness, utilization and impact of novel technology to facilitate diabetes management and care in a safety-net hospital setting. Third, we aim to assess the potential for a high-touch, individualized CHW enhancement to improve uptake and adherence to DSMT and RGM among patients who do not improve within six months. This CHW innovation leverages persons particularly close to the population served who have the potential to strengthen intervention packages cost-effectively.

PI_NAMEs: JACOBS, JACKIE  (contact);MARGELLOS-ANAST, HELEN ;WAGENER, CHRISTINA

PROGRAM_OFFICER_NAME: FREEMAN, WILLIAM

PROJECT_TITLE: Sinai diabetes center


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Social Determinants of Health

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Narrative The long-term goal of this undergraduate research training grant is to increase the number of underrepresented minority students who enter career paths in medicine, science, technology, engineering, and math, as applied to aging. This renewal application builds upon five years of program funding, which provided 32 students from 5 Historically Black Colleges and Universities in South Carolina with research training experiences on the campus of the University of South Carolina.

PI_NAMEs: LEVKOFF, SUE E (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Academic skills;Address;African American;Aging;aging population;aging related;Award;Bachelor's Degree;Behavioral;Biological;career;Career Choice;Clinical;Communities;Complex;disability;disadvantaged background;Diverse Workforce;economic disparity;education research;Educational Grants;Educational workshop;educationally disadvantaged;ethnic minority;Ethnic Population;Evaluation;evidence base;experience;Exposure to;Faculty;faculty mentor;Funding;Goals;Grant;Health care facility;health disparity;Historically Black Colleges and Universities;Individual;Infrastructure;innovation;Institution;interest;Knowledge;Laboratories;Learning;Life;Low income;matriculation;Medicine;meetings;Mentors;Mentorship;minority undergraduate;Outcome;peer;Population;process evaluation;Professional Education;programs;Qualifying;racial population;recruit;Research;Research Training;Resources;role model;Schools;Science, Technology, Engineering and Mathematics;science, technology, engineering, mathematics, and medicine;Scientist;skill acquisition;skills;social;South Carolina;STEM field;STEM program;Strategic Planning;student mentoring;Students;success;Training Programs;undergraduate education;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Minority;underrepresented minority student;Universities;university student;Work

PROJECT_TITLE: South Carolina - Advancing Diversity in Aging Research Undergraduate Program


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease

ORG_CITY: SAN ANTONIO

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Project Narrative In this project, we will investigate how cardiac-specific TCF7L2 isoforms interact with β-catenin to mediate cardiac gene expression in failing human hearts with coronary artery disease and idiopathic dilated cardiomyopathy. Using genetic targeting, we will determine if TCF7L2 is required for cardiac remodeling and dysfunction induced by pressure overload and if TCF7L2 temporal induction in adult mouse hearts is sufficient to cause cardiac remodeling and dysfunction. More importantly, we will evaluate if pharmacologic intervention to interfere TCF7L2 interaction with β-catenin can prevent heart failure after pressure overload or TCF7L2 induction.

PI_NAMEs: LI, FAQIAN  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Adult;Affect;Animal Model;aorta constriction;Armadillo Repeat;Attenuated;beta catenin;Binding;Binding Proteins;Cardiac;Cardiac Myocytes;cardiogenesis;Cells;Clinical;clinical translation;Code;Complex;Coronary Arteriosclerosis;Data;Development;differential expression;disabled;Disease;DNA Binding Domain;Doxycycline;Echocardiography;effective therapy;Exons;Failure;Family;fetal;Fibrosis;Functional disorder;gain of function;Gene Expression;Gene Targeting;Genes;Genetic;Genetic Transcription;Goals;Health;Heart;Heart Abnormalities;Heart Diseases;Heart failure;heart function;Histologic;Human;human disease;human model;Hyperplasia;Hypertrophy;Intervention;Knock-out;loss of function;Mediating;Molecular;Molecular Analysis;Monitor;mouse model;Mus;N-terminal;Neonatal;neonatal mice;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;Nuclear;old mice;overexpression;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Play;Population Study;pressure;prevent;Primary idiopathic dilated cardiomyopathy;programs;Proliferating;promoter;Protein Isoforms;recruit;Research;response;RNA Splicing;Role;Signal Transduction;Single Nucleotide Polymorphism;Site;Specific qualifier value;Stress;System;targeted treatment;TCF Transcription Factor;TCF7L2 gene;Testing;Tetanus Helper Peptide;therapy development;Tissue-Specific Gene Expression;Tissues;transcription factor;Transcriptional Activation;Transgenic Mice;transmission process;Untranslated RNA;Up-Regulation;Variant;WNT Signaling Pathway

PROJECT_TITLE: TCF7L2 Insoforms in Canonical Wnt Signaling During Cardiac Hpertrophy & Failure

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CCHF-S(01)]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: SANTA BARBARA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

ORG_STATE: CA

PHR: Project Narrative General strategies to impose stereocontrol over radical-mediated transformations have long eluded synthetic chemists. By repurposing and engineering naturally occurring metalloenzymes for new-to-nature metalloredox processes, we will develop biocatalytic radical reactions that occur with excellent stereochemical fidelity. Ultimately, this evolvable metalloenzyme platform will allow for the rapid assembly of clinically significant therapeutics of general societal importance.

PI_NAMEs: YANG, YANG  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TITLE: An Evolvable Metalloenzyme Platform for Stereoselective Radical Biocatalysis


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: Framingham

ORG_NAME: KEPHERA DIAGNOSTICS, LLC

ORG_STATE: MA

PHR: PROJECT NARRATIVE Hookworm infection is a parasitic disease that causes significant morbidity in tropical and subtropical regions worldwide. The World Health Organization (WHO) has called for the development of new, low-cost tools for hookworm surveillance, to replace currently used methods which are laborious and low in sensitivity. In this project, we propose to develop a test for human antibodies to hookworm that will meet the requirements set forth by the WHO. In Phase II we will refine this assay to improve sensitivity and specificity, manufacture the product, and scale-up production.

PI_NAMEs: LEVIN, ANDREW E. (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Address;Africa South of the Sahara;Age;Ancylostoma (genus);Anemia;Anthelmintics;Antibodies;Antigens;Area;Asia;assay development;Benchmarking;benzimidazole;Biological Assay;Biological Markers;Biology;candidate marker;Child;Chronic;Chronic Disease;Cognitive;cohort;Collaborations;Communicable Diseases;cost;Country;Detection;Development;Diagnosis;Diagnostic;Drug resistance;Effectiveness;egg;Enzyme-Linked Immunosorbent Assay;Exposure to;Feces;Filarial Elephantiases;Friends;Future;Goals;Growth;Hamsters;hatching;Helminths;Hemorrhage;high risk population;HIV;Hookworm Infections;Hookworms;Human;human model;IgE;Immunoglobulin G;Immunoprecipitation;immunoreactivity;improved;in silico;In Vitro;Incidence;Individual;Infection;interest;Iron deficiency anemia;Laboratories;Letters;Liquid Chromatography;Malaria;Malnutrition;manufacture;manufacturing scale-up;Methods;Microscopic;Microscopy;Molecular;Monitor;Morbidity - disease rate;mortality;Necator americanus;neglected tropical diseases;novel;Old World Hookworm;Onchocerciasis;Outcome;Parasites;Parasitic Diseases;Peptides;Performance;Pharmaceutical Preparations;Phase;Policies;poor communities;Population;Positioning Attribute;Poverty Areas;Predisposition;Pregnant Women;Prevalence;Program Evaluation;programs;Proteins;Proteomics;prototype;Publishing;Reagent;Recombinant Proteins;Recommendation;reproductive;Research;Research Personnel;Resistance;Resources;Sampling;screening;screening panel;Screening procedure;Sensitivity and Specificity;serosurveillance;Serum;Small Intestines;Soil;South America;Specificity;Standardization;stoichiometry;synthetic peptide;tandem mass spectrometry;Testing;Thick;tool;transmission process;Tuberculosis;Universities;vaccine efficacy;Woman;Work;World Health Organization

PROJECT_TITLE: Development of an ELISA for serosurveillance of human hookworm

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-E(13)]


ORG_CITY: BALTIMORE

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: In the United States, about 20,0000 children experience cardiac arrests per year, the majority of whom present to under-resourced and under-trained community hospitals that are unable to provide the high-quality cardiopulmonary resuscitation (CPR) recommended by the Pediatric Advanced Life Support guidelines. Efficient, affordable, and high-quality CPR feedback provided in real-time by augmented reality CPR (AR- CPR), to various providers, could save lives and bridge gaps in who gets high quality care. We will refine AR- CPRs software and hardware, enhance its usability and functionality, and lay the groundwork for improvements in AR-CPRs to be incorporated into future clinical care. 1

PI_NAMEs: JEFFERS, JUSTIN ;KLEINMAN, KEITH  (contact)

PROGRAM_OFFICER_NAME: PATEL, SHEENA

PROJECT_TITLE: AR-CPR: Refinement and Large-Scale Simulation-Based Testing of a Novel Augmented Reality Point of Care Chest Compression Feedback System.

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative A core brain area responsible for memory is the hippocampus, which is impaired in a number of cognitive diseases, including Alzheimer’s. This work contributes to fundamental knowledge about the form of hippocampal representations, and their function in memory-guided cognitive behaviors. In order to address the question of how limits to hippocampal function might affect specific aspects of behavior, we compare memory-guided foraging behavior across animals with different hippocampus sizes, both in simulation and in natural environments.

PI_NAMEs: MACKEVICIUS, EMILY LAMBERT (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TITLE: Probing form and function of memory representations in the hippocampus of memory expert birds


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Chemoproteomics provides an additional and important functional dimension to conventional genomic, transcriptomic, and proteomic data sets; accordingly, activity-based profiling has been successfully applied to a variety of oncologic, metabolic, and infectious diseases to better understand enzyme function under normal and diseased states. However, activity-based profiling has never been thoroughly applied to gain insight into basic ocular enzyme biology or leveraged to provide real-time activity of select enzymes in vivo. Our proposed studies will address both of these aspects, potentially laying the groundwork for more conventional use of activity-based profiling in vision research.

PI_NAMEs: HULLEMAN, JOHN DOUGLAS (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Active Sites;activity-based protein profiling;Affect;Affinity;age related;Age related macular degeneration;Aging;Atlases;Biological Markers;Biology;Caspase;Cell Separation;Cells;Chemicals;chemoproteomics;Choroid;cofactor;Communicable Diseases;Coupled;Data;Data Set;design;Development;Dimensions;Disease;disorder risk;Engineering;enzyme activity;Enzymes;extracellular;Eye;Eye diseases;Family;genome-wide;Genomics;Goals;Health;High temperature of physical object;Imaging Techniques;immunocytochemistry;in vivo;Inherited;inhibitor;insight;Intervention;Knowledge;Label;Locales;Mass Spectrum Analysis;Matrix Metalloproteinases;Measures;Messenger RNA;Metabolic Diseases;Modification;Mus;Mutation;neural;Neural Retina;Normal tissue morphology;novel;Outcome;Physiologic Monitoring;Physiological;protein folding;protein function;Proteins;Proteome;Proteomics;real-time images;Regulation;Research Personnel;Research Project Grants;Retina;Risk Factors;Scientist;Serine Hydrolase;Serine Protease;spatiotemporal;Specificity;Testing;Time;Tissues;tool;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Validation;virtual;Vision research

PROJECT_TITLE: Functional Ocular Chemoproteomics for Retinal Biology Insight and in vivo Enzyme Activity

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Lung;Organ Transplantation;Prevention;Transplantation

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE Patients with lung disease who have better self-management abilities or emotional health have an improved quality of life following lung transplant surgery. Health and wellness coaching is known to improve patients’ self- management abilities and emotional health in certain diseases, such as chronic obstructive lung disease (a.k.a. emphysema). In this application, we will investigate whether a weekly health and wellness coaching intervention by telephone improves pre-transplant self-management abilities and emotional health in patients on the lung transplant waiting list and whether it also improves patients’ quality of life.

PI_NAMEs: KENNEDY, CASSIE COLLEEN (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: actigraphy;Address;Adherence;Adult;Behavior;Board Certification;catalyst;Chronic;Chronic Obstructive Pulmonary Disease;chronic respiratory disease;Clinic;Clinical;clinical care;cost;Data;Deterioration;Disease;Dissemination and Implementation;dissemination trial;Distress;Dyspnea;effective intervention;Emotional;emotional functioning;Emotions;Enrollment;Ensure;Equation;experience;Face;Florida;Foundations;frailty;functional improvement;Future;Goals;Health;health management;implementation study;implementation trial;improved;improved outcome;instrument;Intervention;intervention refinement;Interview;Knowledge;Logistics;Lung Diseases;Lung Transplantation;Measures;Medical;Medicine;Minnesota;Mission;Modeling;Multicenter Trials;negative affect;novel;Obesity;Outcome;Outcome Measure;Participant;Patient Outcomes Assessments;Patient Recruitments;Patient-Focused Outcomes;Patients;Perception;Personal Satisfaction;Pharmaceutical Preparations;Physical activity;physical conditioning;pilot trial;Population;post-transplant;Preparation;prevent;primary outcome;Psychometrics;Pulmonary Emphysema;Quality of life;Questionnaires;randomized trial;Readiness;remote delivery;Research;Research Personnel;resilience;respiratory;Risk Factors;Role;secondary outcome;Self Management;Stress;Structure;Telephone;telephone session;Testing;theories;Therapeutic;Translating;Transplant Recipients;Transplantation;Transplantation Surgery;treatment as usual;trial design;United States National Institutes of Health;Waiting Lists;Washington;Wellness coaching;Work

PROJECT_TITLE: Pre-transplant health coaching to improve patient-reported outcomes in lung transplant candidates

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(JA)]


NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: AUSTIN

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because spinal cord injury causes permanent disability and worsened quality of life. Targeting harmful neuroinflammation after spinal cord injury could lead to discovery of new therapies that improve tissue repair and functional recovery. This preclinical project aims to reveal the untapped therapeutic potential of the circadian-neuroimmune axis after spinal cord injury, and is therefore relevant to NIH’s mission to seek fundamental knowledge that improves health and reduces disability.

PI_NAMEs: GAUDET, ANDREW DAVID (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acute;Address;Agonist;American;Anatomy;Anti-Inflammatory Agents;Behavior;behavior test;Behavioral;Blood;Cell Culture Techniques;Cells;Central Nervous System;circadian;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;clinical predictors;clinically relevant;Coculture Techniques;Data;Development;disability;Genes;Genetic Transcription;Health;Hospitals;Immune;immune activation;Immune system;improved;Inflammation;Inflammatory;Inflammatory Response;Injections;injury recovery;innovation;Intervention;Knockout Mice;Knowledge;Lesion;Lifelong disability;Link;Locomotion;Locomotor Recovery;Macrophage;Mental Health;Methods;Microglia;Mission;Molecular Analysis;Moods;Motor;Mus;Nervous System Physiology;Neuroimmune;neuroimmunology;neuroinflammation;Neurologic;Neurologic Deficit;Neurologic Dysfunctions;Neurological outcome;neurological recovery;Neuronal Plasticity;Neurons;neuroprotection;neurotoxic;novel strategies;novel therapeutics;overexpression;Pain;pain relief;pain symptom;Pathway interactions;Peripheral;pharmacologic;Physiological;pre-clinical;Process;programs;Proteins;Public Health;Quality of life;Recovery;Recovery of Function;repaired;Repression;Research;Role;Severities;single-cell RNA sequencing;Spinal cord injury;System;Testing;Therapeutic;Time;tissue repair;Tissues;Toxic effect;Transcription Repressor;transcriptomics;Transgenic Organisms;United States National Institutes of Health

PROJECT_TITLE: Circadian control of neuroinflammation after spinal cord injury

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Pediatric;Pediatric Cancer;Prevention;Primary Health Care;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: The Pediatric Oncology Education (POE) Program gives students high quality, contemporary cancer-related research experience, introduces them to the latest pediatric cancer research and treatment, and encourages their pursuit of cancer-related careers.

PI_NAMEs: GRONEMEYER, SUZANNE A. (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: 20 year old;Academic degree;academic program;Adolescent;Age;American;anti-cancer research;Area;Attention;Awareness;biomedical profession;Cancer Center;cancer diagnosis;cancer education;Cancer Patient;cancer therapy;career;Career Choice;Cause of Death;Cessation of life;Child;Childhood;childhood cancer survivor;Clinical Research;cohort;COVID-19 pandemic;design;Diagnosis;Disease;Disparity;Doctor of Pharmacy;Doctor of Philosophy;Early Diagnosis;Education;Electronic Mail;empowerment;Epidemiology;experience;Faculty;faculty mentor;Family;Family Practice;Female;Fostering;Friends;Goals;Gynecologic;Health Occupations;improved;Institution;interest;Journals;Knowledge;Laboratory Research;Learning;Longterm Follow-up;Malignant Childhood Neoplasm;Malignant Neoplasms;Manuscripts;Medical;Medical Oncologist;Medical Students;meetings;Mentors;Minority;minority student;Oncologist;Oncology;Operative Surgical Procedures;Participant;Pediatric Oncologist;Pediatric Oncology;pediatrician;Peer Review;Persons;Physicians;Population;pre-doctoral;Prevention;Program Evaluation;Program Reviews;programs;Publications;Publishing;Qualifying;Radiation;recruit;Research;Research Personnel;Research Project Grants;Saint Jude Children's Research Hospital;Science;Scientist;Series;Site;Students;Surgical Oncology;Surveys;Survival Rate;symposium;Techniques;Testing;Time;Translating;undergraduate student;Underrepresented Minority;Underrepresented Populations;United States;Universities;urologic;virtual;web site;Work;Writing

PROJECT_TITLE: PEDIATRIC ONCOLOGY EDUCATION (YEARS 38 - 42)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Racial and ethnic minorities experienced stark health inequities during the COVID-19 pandemic. This study seeks to explain previously unexplored causes of COVID-19 disparities through an evaluation of the inter- related effects of nursing resources and by identifying those hospitals, that despite the odds, achieved equitable outcomes for racial and ethnic minorities during the pandemic. Findings from this study will leverage “lessons learned” from COVID-19 to inform interventions that ensure the allocation of appropriate clinical care resources to patients from diverse backgrounds.

PI_NAMEs: BROOKS CARTHON, JACQUELINE MARGO (contact);KUTNEY LEE, ANN

PROGRAM_OFFICER_NAME: MCNAMARA, KAREN MARIE

PROJECT_TERMS: Accounting;acute care;Address;Attention;barrier to care;black patient;Black Populations;Black race;burden of chronic illness;care delivery;Caring;Characteristics;classification trees;clinical care;clinical risk;Communities;community-level factor;COVID-19;COVID-19 disparity;COVID-19 health disparity;COVID-19 mortality;COVID-19 pandemic;Data;Death Rate;Development;Disadvantaged minority;Discipline of Nursing;Disparity;disparity reduction;Ensure;Equity;ethnic difference;ethnic minority;Ethnic Origin;Evaluation;evidence base;experience;Foundations;Goals;health care quality;health disparity;health equity;health inequalities;Health Insurance;Hispanic;Hispanic Populations;hospital care;hospital readmission;hospitalization rates;Hospitals;Illinois;improved;Individual;Inequity;innovation;Intervention;Link;Literature;Methods;Minority;minority patient;mortality;National Institute of Nursing Research;New York;novel strategies;Nurses;nursing care quality;Nursing Research;Nursing Staff;Outcome;outcome disparities;pandemic disease;Patient Admission;Patient-Focused Outcomes;Patients;Perception;Persons;Phase;Population Heterogeneity;Primary Care Physician;Process;professional atmosphere;Race;racial difference;racial minority;Registered nurse;regression trees;Research;Resources;Respondent;response;Risk Factors;Service delivery model;social factors;social vulnerability;sociodemographic factors;Socioeconomic Factors;Structure;Surveys;System;Systems Development;United States;Variant;Vulnerable Populations;Work

PROJECT_TITLE: Achieving Health Equity During the COVID-19 Pandemic: Lessons Learned from Nurses and High Performing Hospitals

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Services;Networking and Information Technology R&D (NITRD);Patient Safety;Telehealth

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The COVID-19 pandemic has dramatically altered healthcare delivery, rapidly shifting the primary modality of ambulatory care delivery to telemedicine-based virtual encounters that are persisting at high levels. Our project will generate evidence on the implications of this transition for how clinicians use the electronic health record to support care documentation and clinical decision-making. Resulting findings will be used to develop and prioritize design guidelines and translate them into pragmatic strategies to improve EHR support for telemedicine encounters.

PI_NAMEs: ADLER-MILSTEIN, JULIA ROSE (contact);KANNAMPALLIL, THOMAS GEORGE

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Academic Medical Centers;Address;Ambulatory Care;American;California;care delivery;Caring;Clinical;Clinical assessments;clinical decision-making;Cognition;cognitive load;Communication;Continuity of Patient Care;COVID-19;COVID-19 pandemic;Data;data access;Decision Making;design;Diagnostic;Diagnostic tests;Documentation;Electronic Health Record;Evaluation;follow-up;Goals;Guidelines;Health;health care delivery;health care service organization;health data;Health system;Healthcare;improved;innovation;Institution;Interview;Length;Measures;Mediating;medical specialties;Modality;Natural experiment;novel;Outcome;Patient Care;patient-clinician communication;Patients;Pattern;Physicians;Process;Proxy;Recording of previous events;recruit;Sampling;San Francisco;Social Distance;Structure;Telemedicine;Telephone;Translating;Uncertainty;Universities;virtual;Washington;Work

PROJECT_TITLE: Assessing the Effect of Telemedicine on Physician EHR Work, Cognition, and Process Outcomes (ASPIRE)

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Infectious Diseases;Malaria;Natural Products;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: ORLANDO

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

PHR: PROJECT NARRATIVE Malaria is one of the major global health problem afflicting about 219 million people and killing 435,000 individuals annually. Because of the emergence of drug resistance parasites, current therapies for malaria are rapidly loosing their efficacy. The proposed research seeks to identify antimalarial lead compounds from fungal extracts effective against multidrug resistant malaria, thus contributing to the global malaria elimination campaign.

PI_NAMEs: CHAKRABARTI, DEBOPAM  (contact);CICHEWICZ, ROBERT HENRY

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Address;Anti-Infective Agents;Anti-malarials;Appearance;Area;Artemisinins;Bioinformatics;Biological;California;Cellular biology;cellular targeting;Cessation of life;Chemicals;Child;Childhood;Classification;Clinical;Combined Modality Therapy;comparative;Copy Number Polymorphism;Country;CRISPR/Cas technology;Data;Development;Disease;disorder control;drug discovery;Drug Kinetics;Drug resistance;Economics;Effectiveness;efficacy evaluation;efficacy study;Evolution;experience;Florida;fungus;genome editing;genome sequencing;global health;Growth;High Pressure Liquid Chromatography;improved;In Vitro;in vivo;in vivo evaluation;Individual;Interdisciplinary Study;Laboratories;Lead;Libraries;Liver;macromolecule;Malaria;Measures;Mediating;Medicine;Methods;Modeling;Molds;Molecular Target;mortality;Multi-Drug Resistance;Mus;Mutation;Myanmar;Natural Products;Natural Products Chemistry;Natural Selections;Nature;next generation;NMR Spectroscopy;novel;novel lead compound;novel therapeutics;Oklahoma;Parasite resistance;Parasites;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacology;pharmacophore;Phenotype;Population;Predisposition;Prevalence;Property;Proteins;Proteome;Research;Resistance;Resistance profile;resistant strain;Resolution;Resource Development;Resources;scaffold;screening;secondary metabolite;small molecule therapeutics;Source;Southeastern Asia;Specimen;Spectrometry, Mass, Electrospray Ionization;Structure;targeted treatment;Texas;Therapeutic;Time;Universities;Validation;Vietnam;whole genome

PROJECT_TITLE: Novel Antimalarials from Fungi

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-N(02)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Lung;Nanotechnology;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: Stellenbosch

ORG_NAME: STELLENBOSCH UNIVERSITY

PHR: NARRATIVE The infectious bacterial disease tuberculosis poses a significant global threat to human health, since it is the leading cause of death due to infectious disease in South Africa, with over 9,000 reported cases in the USA in 2017. Here, nanoparticles, which mimic the bacteria in appearance, will be investigated to modulate the antibacterial response of the host immune cells, and thus achieve eradication of the bacteria. Knowledge gained could contribute to improved tuberculosis control strategies, specifically more effective drug treatment regimens.

PI_NAMEs: DUBE, ADMIRE ;REINEKE, JOSHUA JAMES;SAMPSON, SAMANTHA LEIGH (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Address;Adherence;Advanced Development;Alveolar Macrophages;Animal Model;Antibacterial Response;Antibiotics;antimicrobial;Antimicrobial Effect;Appearance;Architecture;Artificial nanoparticles;Award;Bacteria;Bacterial Infections;beta-Glucans;Biocompatible Materials;Biomimetics;Bone Marrow;Case Study;Cause of Death;Cells;Cessation of life;Clinical;co-infection;Communicable Diseases;Country;Data;Defense Mechanisms;Development;Disadvantaged;Disease;Drug resistance;Drug resistant Mycobacteria Tuberculosis;Drug Tolerance;drug-sensitive;Exhibits;Fluorescence;Formulation;Funding;Goals;Health;HIV;Human;Hybrids;Immune;Immune response;Immunity;Immunologics;Immunology;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;Incidence;Infection;innovation;Institution;Invaded;Kinetics;Knowledge;latent infection;Lipids;Macrophage;Macrophage Activation;Mediating;Metals;Methods;mimicry;Modeling;Molecular;multidisciplinary;Multidrug-Resistant Tuberculosis;Mus;mycobacterial;Mycobacterium tuberculosis;Mycobacterium tuberculosis H37Rv;Mycolic Acid;nanomedicine;nanoparticle;nanopolymer;Nanotechnology;novel;novel therapeutic intervention;Outcome;pathogen;Pathway interactions;persistent bacteria;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;polycaprolactone;Polymers;Polysaccharides;Population;Positioning Attribute;Property;Public Health;Publishing;Regimen;Reporter;Research;Research Personnel;Research Project Grants;Research Training;resistant strain;response;Rod;Scientist;Shapes;Signal Transduction;South Africa;South Dakota;Standardization;Structure;System;tool;trafficking;Training Programs;Treatment Failure;Treatment Protocols;Tuberculosis;tuberculosis treatment;United States;United States National Institutes of Health;Universities;uptake;Virulent;Work;Zimbabwe

PROJECT_TITLE: Nanoparticle-based host-directed therapies for eradication of Mycobacterium tuberculosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-W(50)R]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: SHREVEPORT

ORG_NAME: LOUISIANA STATE UNIV HSC SHREVEPORT

ORG_STATE: LA

PHR: PROJECT NARRATIVE Cellular events that alter vessel architecture, drive extracellular matrix degradation, and promote vascular calcification cause atherosclerotic plaque destabilization, ultimately increasing the risk for acute cardiovascular events. Our research identifies that impaired putrescine synthesis in vascular smooth muscle cells (vSMCs) enhance these features of plaque instability. Understanding the mechanisms that impair putrescine biosynthesis in vSMCs during atherosclerosis may provide novel therapeutic strategies to stabilize rupture- prone atheromas.

PI_NAMEs: YURDAGUL, ARIF  (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: Acute;Adipocytes;Alanine;amino acid metabolism;Amino Acids;Anabolism;Anti-Inflammatory Agents;Architecture;Arterial Fatty Streak;ATAC-seq;Atherosclerosis;Attenuated;Automobile Driving;Biological Assay;Blocking Antibodies;calcification;Calcium;Cardiovascular system;Cell Culture System;cell dedifferentiation;Cell Differentiation process;Cell Physiology;Coupled;Data;Deposition;Dominant-Negative Mutation;Enzymes;Event;experience;Extracellular Matrix;Extracellular Matrix Degradation;Extracellular Matrix Proteins;Fibroblasts;Gene Expression;Genes;Genetic Markers;HDAC9 gene;Human;Impairment;In Vitro;in vivo;Individual;Infection;Inflammation;Knock-in Mouse;Knockout Mice;Lead;Link;Lipids;LoxP-flanked allele;Luciferases;Macrophage;Matrix Metalloproteinases;Mediating;Mediator;Metabolic;Metabolic Pathway;Metabolism;Molecular;Morbidity - disease rate;mortality;mortality risk;mouse model;Mus;mutant;Mutate;Myocardial Infarction;myocardin;next generation;novel;novel therapeutic intervention;Nuclear;Ornithine;Ornithine Decarboxylase;Osteoblasts;oxidized low density lipoprotein;Pathologic;Pathway interactions;Phenotype;Polyamines;polycation;Process;Production;programs;Putrescine;Recurrence;Research;Residual state;Resistance;response;Risk;Role;Rupture;Sepsis;single-cell RNA sequencing;Site;Smooth Muscle Myocytes;Snoring;Stimulus;Stroke;Testing;Therapeutic;TNF gene;transcriptome sequencing;Vascular calcification;Vascular remodeling;Vascular Smooth Muscle

PROJECT_TITLE: Dysregulations in Polyamine Metabolism During Atherosclerosis

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: NEW YORK

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: The prefrontal cortex (PFC) of the brain controls decision making and impulsive behavior, and changes in the PFC are thought to underlie compulsive drug-taking and relapse in drug and alcohol abusers. A detailed understanding of what alcohol does in the PFC will help us to understand how the existing drugs work, and identify new targets in the brain so we can develop better drugs to treat alcohol use disorders more effectively. We will study the effects of alcohol in the PFC area of the mouse brain after the equivalent of between one and six drinks, using new methods for recording from brain cells, imaging the cells with infra-red light, using a specially equipped microscope and camera.

PI_NAMEs: HARRISON, NEIL L. (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: alcohol abuser;alcohol effect;alcohol exposure;alcohol measurement;alcohol sensitivity;alcohol use disorder;Alcohols;antagonist;Area;Behavior;Behavioral;Brain;brain cell;brain control;calcium indicator;cellular imaging;Complex;Cues;Data;Decision Making;designer receptors exclusively activated by designer drugs;Disinhibition;Dopamine;Dopamine Antagonists;Dopamine D1 Receptor;Dopamine D2 Receptor;dopaminergic neuron;Dose;drinking;drug abuser;Ethanol;experimental study;Functional disorder;Genetic;Goals;hippocampal pyramidal neuron;Image;Imaging Techniques;Impulsive Behavior;In Vitro;in vivo;in vivo imaging;Interneurons;Light;Measures;Mediating;Methods;Microscope;Mus;neuronal circuitry;Neurons;Parvalbumins;Pharmaceutical Preparations;pharmacologic;Prefrontal Cortex;prevent;promoter;Publishing;Pyramidal Cells;receptor;Relapse;Reporting;response;Role;social;Somatostatin;Subgroup;substance abuser;two-photon;Tyrosine 3-Monooxygenase;Vasoactive Intestinal Peptide;Ventral Tegmental Area;Work

PROJECT_TITLE: Alcohol and Interneurons in the Prefrontal Cortex

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Sleep Research

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Pediatric sleep problems are a major public health concern and sleep in children with autism spectrum disorders (ASD) is a very high priority for research (see IACC Strategic Plan, Objective 2). Our application, “Sleep, Brain Development, and Behavioral Correlates in a Longitudinal Cohort of Children at Risk for ASD,” will leverage a recently funded longitudinal follow-up of 300 7-10 year-old children at high familial risk for ASD (HR; with ASD n~100; without ASD ~200) and 100 low familial risk for ASD (LR) who have had multiple MRI and behavior assessments since infancy through the NIH Autism Center of Excellence Infant Brain Imaging Study (IBIS). Across these three groups (HR-ASD, HR-NonASD, and LR) our aims are to 1) characterize sleep problems in the home using actigraphy, validated by sleep diary, and parent report, (2) examine longitudinal brain trajectories (from infancy) associated with sleep problems in school-age, and (3) examine the relationship of longitudinal behavior trajectories and concurrent behavior to sleep problems in school-age to increase understanding of the neurobiology, developmental characteristics, and co-morbid conditions associated with sleep problems, with implications for developing novel sleep interventions and improving outcomes in this vulnerable population.

PI_NAMEs: ESTES, ANNETTE  (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: 10 year old;Accounting;actigraphy;adverse outcome;Affect;Affective;affective disturbance;Age Months;Anxiety;Autism Diagnosis;autism spectrum disorder;autism symptoms;autistic children;Beds;Behavior;Behavior assessment;Behavior Disorders;Behavioral;Biological;biopsychosocial;Brain;Brain imaging;Cerebrospinal Fluid;Characteristics;Child;Childhood;circadian;Circadian Dysregulation;Clinical;Cognition;Cognitive;cohort;Communication;comorbidity;Data;design;Development;developmental disease;Diagnosis;diaries;Disease;early childhood;endophenotype;Environment;executive function;Family history of;follow-up;Follow-Up Studies;Foundations;Funding;Goals;Growth;Health;Hippocampus;Home;imaging study;improved outcome;improvement on sleep;Individual;infancy;Infant;Intervention;Light;Link;Literature;Longitudinal cohort;Magnetic Resonance Imaging;Maintenance;media use;Medical;Mental disorders;Modeling;Moods;multimodality;Nature;neural;neural correlate;Neurobiology;novel;Outcome;Parents;Pathogenesis;Pattern;Phenotype;Population;Prevalence;Problem behavior;psychiatric comorbidity;Public Health;Reporting;Research;Research Priority;Risk;Sampling;Schedule;School-Age Population;Severities;Siblings;Sleep;Sleep Deprivation;Sleep Disorders;sleep health;sound;Strategic Planning;Structure;Temperature;Testing;United States National Institutes of Health;vigilance;Vulnerable Populations


ORG_CITY: VALHALLA

ORG_NAME: NEW YORK MEDICAL COLLEGE

PHR: Narrative Obesity is now considered a worldwide epidemic and a risk factor for insulin resistance, diabetes, cardiovascular diseases, liver disease and immunological/infectious diseases such as COVID-19. Our recent findings in humans and mice identified the G-protein-coupled receptor 75 (GPR75) and its ligand, the lipid mediator 20-HETE as significant contributors to obesity and its associated cardiovascular and metabolic complications. Understanding the mechanisms by which activation of GPR75 leads to exacerbation of diet-driven adiposity, insulin resistance and vascular dysfunction will lead to novel therapeutics to treat obesity and its associated complications.

PI_NAMEs: SCHWARTZMAN, MICHAL LANIADO (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Adipocytes;Adipose tissue;Amino Acids;Androgens;Animal Model;antagonist;Attenuated;Binding;Biology;blood glucose regulation;C-terminal;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;Cardiovascular system;Cell Communication;Cells;Chromosomes;Classification;Coculture Techniques;Communicable Diseases;Couples;COVID-19;Cytochrome P450;Data;Development;Diabetes Mellitus;Diet;driving force;Endothelial Cells;endothelial dysfunction;Endothelium;Epidemic;exome sequencing;experimental study;feeding;Functional disorder;Funding;G-Protein-Coupled Receptors;Genes;global health;Goals;GPR75 gene;High Fat Diet;Human;human model;Hydroxyeicosatetraenoic Acids;Hyperglycemia;Hyperinsulinism;Hypertension;hypertensive;Hypertrophy;Immunologics;Impairment;Individual;Inflammatory;Insulin Receptor;insulin receptor substrate 1 protein;Insulin Resistance;insulin signaling;Knockout Mice;Ligands;Link;lipid mediator;Liver;Liver diseases;loss of function;Maps;Mediating;Metabolic;Metabolic Diseases;Metabolic syndrome;Mitochondria;Mixed Function Oxygenases;Monitor;Morbidity - disease rate;Mus;Muscle Contraction;Myocardial Infarction;Nonesterified Fatty Acids;novel;novel therapeutics;Obesity;obesity development;Orphan;overexpression;Pathogenesis;Phenotype;Phosphorylation;Plasma;Play;prevent;Production;programs;Proteins;receptor;Relaxation;Risk Factors;Role;Science;Signal Transduction;Skeletal Muscle;Smooth Muscle;Stroke;Systemic Therapy;Tail;Testing;Thinness;Tissues;Transgenic Mice;Variant;Vascular Diseases;Vascular Endothelium;Visceral fat;Weight Gain;Wild Type Mouse

PROJECT_TITLE: GPR75 in obesity-driven cardiovascular and metabolic complications


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Pediatric

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: PROJECT NARRATIVE Psychiatric disorders pose challenges to neurobiological analysis as they are complex, routinely co-occur, and are operationalized using behavioral symptoms. We propose to examine the neurobiological basis of reaction time variability in the Adolescent Brain Cognitive Development (ABCD) study in order to explore heterogeneity in Attention-Deficit/Hyperactivity Disorder (ADHD). This work may help us better understand how to identify and treat individuals with ADHD.

PI_NAMEs: EPSTEIN, JEFF N.;TAMM, LEANNE  (contact)

PROGRAM_OFFICER_NAME: PACHECO, JENNIFER LYNN

PROJECT_TERMS: Adolescent;Age;age related;aged;Attention;Attention deficit hyperactivity disorder;autism spectrum disorder;base;Behavior Therapy;Behavioral;Behavioral Symptoms;biobehavior;Biological Markers;biological systems;Brain;Child;Childhood;Clinical;clinical heterogeneity;Code;Cognitive;cognitive development;comorbidity;Complex;Data;Detection;Development;Diagnosis;Diagnostic;diagnostic criteria;Diffusion;Disease;Disparate;Etiology;Functional disorder;Future;Goals;Heterogeneity;Impairment;improved;inattention;indexing;Individual;individual variation;individualized medicine;Interview;Machine Learning;Measures;Mental disorders;Modeling;motor control;multidimensional data;National Institute of Mental Health;neural correlate;neurobiological mechanism;Neurobiology;neuroimaging;Pattern;pharmacologic;Phenotype;Population;Probability;Process;prospective;psychiatric comorbidity;psychologic;Psychopathology;Reaction Time;recruit;Research Domain Criteria;Risk Factors;Sampling;Severities;social;Source;statistical learning;Structure;Subgroup;success;sustained attention;Symptoms;System;targeted treatment;tau Proteins;theories;Thick;trend;United States National Institutes of Health;Validation;Variant;Work

PROJECT_TITLE: Parsing Neurobiological Bases of Heterogeneity in ADHD

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_CITY: SCOTTSDALE

ORG_NAME: VITALANT

ORG_STATE: AZ

PHR: PROJECT NARRATIVE While the advent of antiretroviral therapy (ART) has significantly decreased the morbidity and mortality associated with HIV infection, a cure is not achieved, and ART must therefore be taken on a lifelong basis. In this project, we pursue the hypothesis that circulating cell-free DNA in plasma that can be conveniently and non-invasively measured will enable us to predict if and when HIV will rebound when an individual stops taking ART. In addition, we pursue the hypothesis that cell-free DNA that circulates throughout the human body may transmit key signals that activate antiviral immunity and prevent HIV recrudescence when ART is stopped.

PI_NAMEs: PILLAI, SATISH KUMAR (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Advanced Development;Aftercare;age acceleration;antiretroviral therapy;antiviral immunity;Apoptosis;Binding;Biological Markers;cancer diagnosis;CD4 Positive T Lymphocytes;Cell Death;cell free DNA;Cells;Characteristics;Chronic;Circulation;Clinical;Clinical Oncology;cohort;Collection;Cytidine Deaminase;cytokine;Data;Death Rate;diagnostic strategy;Dimensions;Disease;Disease remission;disorder risk;DNA Packaging;Enabling Factors;Evaluation;Exhibits;experience;extracellular vesicles;HIV;HIV Antibodies;HIV Infections;Human body;Immune;Immunologics;in vivo;Individual;Inflammation;Inflammatory;Integration Host Factors;interest;Interferon Type I;Interferons;Interruption;Kinetics;Link;liquid biopsy;Macrophage;Measurement;Measures;Mediating;methylome;Mitochondrial DNA;mitochondrial dysfunction;Molecular;monocyte;Morbidity - disease rate;mortality;Mutation;next generation sequencing;Nucleic Acids;pharmacologic;Phenotype;Plasma;Plasma Cells;Predisposition;prevent;prognostic significance;Recrudescences;Recurrent disease;Refractory;response;Sampling;Selection for Treatments;Signal Transduction;Study Section;System;Time;transmission process;uptake;Viral;viral rebound;Virus Latency

PROJECT_TITLE: Innate Sensing of Cell-Free DNA and the Interferon-Mediated Control of HIV In Vivo

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: FULLERTON

ORG_DEPT: BIOLOGY

ORG_NAME: CALIFORNIA STATE UNIVERSITY FULLERTON

PHR: Project Narrative The main goals of the U-RISE program at Cal State Fullerton are to recruit and provide biomedical research training to undergraduates from under-represented or disadvantaged backgrounds; nurture their academic and research skills; and place graduating U-RISE scholars in various PhD or MD-PhD programs. The program will track all participants and will disseminate its achievements through various media platforms. Overall, the program endeavors to increase the diversity of highly-trained biomedical researchers and produce scientists who will serve their community and the public, as well as work diligently on health-related issues faced by our nation.

PI_NAMEs: CUAJUNGCO, MATH P (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Achievement;Admission activity;Assessment tool;Biomedical Research;career;CCL7 gene;college;Communication;disadvantaged background;Doctor of Philosophy;Educational process of instructing;Educational workshop;Electronic Mail;Enrollment;Environment;experience;faculty mentor;Funding;Goals;graduate school;hands on research;improved;Institution;Journals;Laboratories;Measurable;Measures;mentoring community;Mentors;Performance;programs;Publications;Qualifying;recruit;Reproducibility;Research;responsible research conduct;Science;skill acquisition;skills;STEM field;Students;success;summer research;symposium;Telephone;Training;undergraduate research;undergraduate student;web site;Writing

PROJECT_TITLE: U-RISE at Cal State Fullerton

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: YALE UNIVERSITY

PHR: Project Narrative Routine mammography screening for early cancer detection has significantly reduced breast cancer mortality, but also subjects women to several potential harms, including incorrect results and unnecessary recall with po- tentially invasive procedures. The goal of this project is to increase accuracy of breast cancer detection and risk estimation through the development of new deep learning models that consider a patient’s mammogram screening history. This work would improve breast cancer detection, inform individualized screening protocols, and guide development and monitoring of tissue-modifying preventive cancer treatments.

PI_NAMEs: DVORNEK, NICHA C (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: 3-Dimensional;Adopted;Anxiety;Appearance;Architecture;Attention;Biological Markers;Biomedical Engineering;Biopsy;Breast;Breast Cancer Detection;Breast Cancer Model;Breast Cancer Risk Factor;breast density;Cancer Detection;cancer risk;cancer therapy;Classification;Clinical;Complex;computer aided detection;Computer Vision Systems;convolutional neural network;Data;Data Set;Decision Making;deep learning;deep learning model;demographics;Dependence;detection platform;Development;Digital Breast Tomosynthesis;Early Diagnosis;Elements;Eligibility Determination;Equilibrium;Exclusion;experience;Family;Future;Goals;Harm Reduction;High Risk Woman;Hospitals;Image;Image Analysis;improved;Label;Learning;longitudinal analysis;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Mammography;Medical;Methodology;Methods;Modeling;Monitor;mortality;neural network;Neural Network Simulation;novel;Patients;Performance;pre-trained model;predictive modeling;Preventive;Preventive treatment;Procedures;radiologist;Reading;Recording of previous events;Risk;Risk Assessment;Risk Estimate;Role;routine screening;screening;Screening for cancer;Series;spatiotemporal;Specialist;System;Technology;Testing;Time;Tissues;tool;Training;tumor;Woman;women subjects;Work;Workload

PROJECT_TITLE: Interpretable Deep Learning Models for Analysis of Longitudinal 3D Mammography Screenings

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science

ORG_CITY: GREENSBORO

ORG_NAME: UNIVERSITY OF NORTH CAROLINA GREENSBORO

ORG_STATE: NC

PHR: NARRATIVE The University of North Carolina at Greensboro U-RISE will be a comprehensive undergraduate training program that will directly contribute to increasing the percentage of underrepresented students pursuing graduate studies in preparation for careers in the biomedical research workforce. The program synchronizes faculty development, undergraduate research experiences, and curricular activities to create an inclusive environment previously shown to promote student success.

PI_NAMEs: MCLEAN, BRYAN STEPHEN;OBARE, SHERINE O.;PETERSEN, KIMBERLY SUE (contact)

PROJECT_TERMS: Biomedical Research;biomedical scientist;career preparation;Communication;Communities;community building;Competence;design;Discipline;Doctor of Philosophy;Educational Status;Educational workshop;Ensure;Environment;Evaluation;experience;fundamental research;Future;Goals;graduate student;Instruction;Interdisciplinary Study;Knowledge;Laboratories;Leadership;meetings;Mentors;Monitor;Motivation;multidisciplinary;North Carolina;Participant;Population;Postdoctoral Fellow;programs;Research;research faculty;Research Personnel;Research Project Grants;Science;Scientist;skill acquisition;skills;Social Development;Social Impacts;social integration;Societies;Students;success;Talents;Training Programs;translational impact;undergraduate student;Underrepresented Students;Universities

PROJECT_TITLE: UNC-Greensboro U-RISE: Engage, Sustain, and Prepare Future PhD Biomedical Scientists