ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: PROJECT NARRATIVE  This project will develop a software system to characterize the retinotopic maps of the human visual areas or the visual signaling pathways by analyzing functional magnetic resonance imaging (fMRI) data. Once developed, the software tools can be extended to analyze data from patients with visual impairment and other neurological and psychiatric disorders, such as glaucoma, age-related macular degeneration (AMD), cortical blindness, and preclinical neurodegenerative diseases.

PI_NAMEs: LU, ZHONG-LIN ;WANG, YALIN  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Adopted;Age related macular degeneration;Algorithms;Area;Atlases;Award;Bayesian Analysis;Bayesian Method;Bayesian Modeling;Brain;Brain imaging;Cerebral cortex;Cognition;Cognitive;Collaborations;Communities;Computing Methodologies;connectome;Cortical Blindness;Data;Data Analyses;Data Set;Development;Diagnosis;Disease;Early Diagnosis;Early treatment;Economic Burden;Ensure;extrastriate visual cortex;Eye;Functional Magnetic Resonance Imaging;geometric methodologies;Geometry;Glaucoma;Human;human data;Image;Imaging Techniques;improved;Individual;Individual Differences;Knowledge;Legal patent;Magnetic Resonance Imaging;Manuals;Maps;Mathematics;Measurement;Measures;Mental disorders;Methods;Modeling;morphometry;National Eye Institute;Nervous System Disorder;Neurodegenerative Disorders;neuroimaging;Neurons;Noise;non-invasive imaging;novel;online resource;open source;Patients;Perception;Persons;Play;Population;Population Statistics;pre-clinical;preservation;Procedures;productivity loss;programs;Property;Psychophysics;Publishing;Qualifying;rehabilitation strategy;Rehabilitation therapy;Research;Research Personnel;Resolution;response;Retina;retinotopic;Role;Scheme;Scientist;Series;Signal Pathway;Signal Transduction;Societies;software development;software systems;Software Tools;Source Code;Specialist;Structure;Surface;Techniques;tool;Treatment Cost;Vision;Vision Disorders;Visual;Visual Cortex;Visual impairment;visual stimulus;Visual System;Work;World Health Organization

PROJECT_TITLE: Hierarchical Bayesian Analysis of Retinotopic Maps of the Human Visual Cortex with Conformal Geometry


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PI_NAMEs: MOHAMED, NIHAL  (contact)

PROJECT_TERMS: Agreement;career;Climate;cohort;Collaborations;Common Data Element;Communities;Data;Data Collection;data management;design;Development Plans;diversity and inclusion;Effectiveness;Ensure;Environment;Evaluation;Faculty;Faculty Recruitment;faculty research;Focus Groups;Goals;higher education;Hybrids;implementation process;improved;Informatics;Institution;Institutional Policy;Interview;Investigation;Lead;Leadership;Measures;Mediation;medical schools;Medicine;meetings;member;Methods;Minority Groups;Modeling;Monitor;Outcome;Outcome Assessment;Precede-Proceed Model;Procedures;Process;programs;Reporting;Research;Resources;Science;Scientific Advances and Accomplishments;Scientist;social;standardize measure;success;Surveys;Teacher Professional Development;Testing;timeline;Underrepresented Minority;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Evaluation Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-Y]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

ORG_CITY: SAINT LOUIS

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative. Washington University supports a large and diverse group of vision scientists who, collectively, make a substantial contribution to the diagnosis and treatment of blinding eye disease. The provision of shared resources and technical support through the Center Core allows investigators to make far more rapid scientific progress than would otherwise be possible. Additionally, the Center Core fosters collaborations between established investigators, draws new researchers to vision research, and supports the career development of junior faculty.

PI_NAMEs: BASSNETT, STEVEN  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Anatomy;Bioinformatics;Biological Models;Biology;Biometry;career development;Collaborations;Core Grant;CRISPR/Cas technology;design;Diagnosis;embryo cryopreservation;Environment;Equipment;experimental study;Eye diseases;Faculty;Fostering;Funding;Gene Targeting;Genomics;Goals;Image;immunocytochemistry;In Situ Hybridization;Individual;instrumentation;Knockout Mice;large datasets;Methodology;Microscope;Molecular Genetics;multi-photon;Mus;next generation;Ophthalmology;Pathology;Preparation;Production;Reporting;Research;Research Design;Research Personnel;Resource Sharing;Resources;Scientist;Services;sperm cell;Statistical Data Interpretation;Talents;Testing;Tissues;Training;transcriptome sequencing;Transgenic Organisms;Universities;Viral Vector;Vision;Vision research;vision science;visual performance;Visual System;Washington

PROJECT_TITLE: Core Grant for Vision Research


ADMINISTERING_IC: AR

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Clinical Research;Genetics;Immunotherapy;Rare Diseases;Scleroderma

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The goal of this proposal is to study RNA polymerase III-specific CD8+ T cells in the peripheral blood and target tissues of patients with co-incident cancer and scleroderma. Identifying distinct RNA polymerase III epitopes recognized by CD8+ T cells, which we believe to play a fundamental role in disease initiation and propagation, may inform us of candidate disease-specific diagnostic, monitoring and therapeutic tools. Moreover, this proposal seeks to enhance our understanding of the mechanistic relationship between cancer and autoimmunity in general.

PI_NAMEs: TINIAKOU, ELENI  (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Address;Affect;anti-cancer;anti-tumor immune response;Antibodies;antigen processing;antigen-specific T cells;Antigens;Antitumor Response;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmunity;autoreactivity;Award;Bioinformatics;Biological Assay;Blood Cells;Blood Vessels;cancer cell;Cancer Patient;cancer risk;cancer site;carcinogenesis;career;career development;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Complex;Cross Presentation;Cross Reactions;cytotoxic;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data;Dendritic Cells;design;Development;Diagnostic;Disease;Epitopes;Etiology;experience;Fibrosis;fitness;Flow Cytometry;Foundations;Frequencies;Future;Genes;Goals;Grant;Granzyme;Immune response;Immune system;Immunoglobulins;Immunologic Surveillance;Immunologics;Immunology;Immunotherapy;insight;Link;Loss of Heterozygosity;Lung;Malignant Neoplasms;Measures;Mediating;Mentors;MHC Class I Genes;Monitor;Morbidity - disease rate;mortality;Mutate;Mutation;Names;neoplastic cell;nonsynonymous mutation;novel;Pathogenesis;Patients;peptide I;Peptides;peripheral blood;Phenotype;Play;Polymerase;Population;pressure;Production;Property;Proteins;Publications;Recording of previous events;Research Personnel;Resources;Rheumatism;Rheumatology;RNA Polymerase III;Role;Sampling;Scleroderma;Shapes;Site;skills;Skin;skin disorder;skin fibrosis;Skin Tissue;Somatic Mutation;Specificity;Systemic Scleroderma;T cell response;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Epitopes;Technology;Therapeutic;therapeutic target;Time;Tissues;tool;translational immunology;Translational Research;tumor;Tumor Immunity;Tumor Tissue;Vascular Diseases;Work

PROJECT_TITLE: RNA Polymerase III specific CD8+ T cells: a mechanistic insight into cancer-induced autoimmunity in scleroderma

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: VERMILLION

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF SOUTH DAKOTA

ORG_STATE: SD

PHR: PROJECT NARRATIVE SD BRIN has supported a robust network of faculty researchers throughout South Dakota in developing and maintaining new areas of biomedical research by providing expert resources in core facilities available to all researchers. In addition, SD BRIN has maintained a strong undergraduate research fellows program at predominantly undergraduate institutions (PUI) with growing research cultures to develop future biomedical researchers and to assist faculty mentors with their cutting-edge research efforts. The faculty fellows program has allowed PUI faculty to concentrate on their research efforts and use this support to increase publications and application to external funding agencies.

PI_NAMEs: HUBER, VICTOR CHESTER (contact)

PROGRAM_OFFICER_NAME: ZHOU, YANG

PROJECT_TERMS: Address;Area;Award;Bioinformatics;Biomedical Research;career;cell growth;Cells;Cellular biology;Core Facility;Databases;Development;Education;Faculty;faculty mentor;Funding;Funding Agency;Future;Genetic;Genomics;Genotype;Growth;Human Resources;insight;Institution;interest;Lead;Libraries;medical schools;member;microbial;National Institute of General Medical Sciences;Network Infrastructure;Nucleic acid sequencing;Phase;Program Research Project Grants;programs;Proteomics;Publications;Research;Research Personnel;Research Support;Resources;Science;science education;South Dakota;student participation;Students;Training;tribal college;undergraduate research;undergraduate student;United States National Institutes of Health;Universities

PROJECT_TITLE: South Dakota Biomedical Research Infrastructure Network


ADMINISTERING_IC: HG

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Genetics;Health Services;Human Genome;Primary Health Care

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative. This K99/R00 Pathway to Independence Award will prepare the candidate to become an independent, mixed-methods ELSI researcher pursing a research program on ethical issues related to the actionability of genomic information. The study examines the values and assumptions underlying conceptualizations of the actionability of genomic information for healthy populations. Results of the study will contribute to the ethical and effective implementation of genomic sequencing into care for healthy populations.

PI_NAMEs: OWENS, KELLIE NICOLE (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, DAVE J

PROJECT_TERMS: American;Award;Bioethics;biomedical informatics;career;Caring;Clinical;clinical implementation;Collaborations;Consensus;Data;Development;Diagnosis;directed attention;Disease;Disputes;Educational workshop;Ethical Issues;ethical, legal, and social implication;Ethics;Faculty;Future;Genetic;genetic information;genome sciences;Genomics;Goals;Guidelines;Health;health management;Healthcare;Individual;innovation;Interdisciplinary Study;Intervention;Interview;Laboratories;Level of Evidence;lifestyle intervention;Literature;Medical;Medical Genetics;medical schools;Medical Sociology;Mentors;Mentorship;Methodology;Methods;Natural Language Processing;Paper;Pathogenicity;Pathway interactions;Patients;Penetrance;Persons;Policies;policy recommendation;poor health outcome;Population;Positioning Attribute;prevent;Primary Care;primary care provider;primary care setting;programs;Provider;Publishing;Qualifying;Qualitative Methods;Recording of previous events;Research;Research Personnel;Research Priority;Risk;Science;screening;Severities;skills;Structure;Surveys;Technology;Testing;Training;Training Programs;translational genomics;Variant

PROJECT_TITLE: Conceptualizing Actionability in Clinical Genomic Screening

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Prevention;Radiation Oncology;Rare Diseases

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PI_NAMEs: BLACK, JENNIFER D. (contact)

PROJECT_TERMS: Address;African American population;anti-cancer research;Area;Autopsy;Award;Basic Science;Biological Markers;biomarker development;biomarker discovery;biomarker validation;Black race;Cancer Care Facilities;cancer cell;Cancer Center;Cancer Center Support Grant;Catchment Area;Cell Cycle Regulation;Cell Proliferation;Cessation of life;Chemoresistance;Clinic;Clinical;Clinical Investigator;Clinical Research;Clinical Sciences;clinical translation;Clinical Trials;Collaborations;college;Colorectal Cancer;colorectal cancer screening;Colorectal Neoplasms;Death Rate;Detection;Development;diagnostic biomarker;diagnostic tool;Direct Costs;Disease;Disease Management;Disparity population;Doctor of Philosophy;Environment;Evaluation;Faculty;Foundations;Functional disorder;Funding;Future;Goals;Grant;Growth;High School Student;Human;In Vitro;in vivo;Incidence;inter-institutional;interest;International;Invaded;Investments;Journals;Leadership;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of pancreas;Malignant Neoplasms;Manuscripts;Medical center;Medical Oncologist;Medicine;meetings;member;Mentors;Middle School Student;Minority Groups;Mission;Nature;NCI Center for Cancer Research;Nebraska;Neoplasm Metastasis;new therapeutic target;next generation;novel;novel diagnostics;novel marker;novel strategies;novel therapeutic intervention;novel therapeutics;Nursing Faculty;oncology trial;Organoids;Pancreas;pancreatic cancer model;pancreatic cancer patients;pancreatic neoplasm;Pathogenesis;Pathologist;Patients;Peer Review;Phase;Pilot Projects;Play;porcine model;pre-clinical;Pre-Clinical Model;Prognosis;Prognostic Marker;prognostic tool;programs;Publications;Publishing;Radiation Oncologist;Radiation Oncology;Radiation Protection;radiation resistance;radioprotected;Radiosensitization;recruit;Research;Research Personnel;Research Support;Research Training;Resistance;Resource Sharing;risk stratification;Role;Scientist;Series;Signal Transduction;success;Surgical Oncologist;Testing;Therapeutic Trials;Tissue Banks;Tissue Microarray;Training Activity;Training and Education;Translating;Translational Research;Translations;treatment response;tumorigenesis;Universities;working group

PROJECT_TITLE: Gastrointestinal Cancer Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Diabetes;Immunotherapy;Natural Products;Transplantation

ORG_CITY: KANSAS CITY

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative Islet transplantation is a cure for Type 1 diabetes, but transplanted islets are susceptible to immune-mediated destruction. Encapsulation of islets with a protective biomaterial that retains insulin secretion, but also prevents recognition by the immune system is highly desired. We will determine if islet encapsulation with a novel antioxidant and immune system modulator, tannic acid and CTLA-4-Ig, respectively, can mediate immune suppression and prolong islet function after transplantation in a subcutaneous site.

PI_NAMEs: KHARLAMPIEVA, EUGENIA ;TSE, HUBERT M (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: adaptive immune response;Address;Adverse effects;Alginates;allograft rejection;Allografting;allotransplant;Antioxidants;Area;arm;Autoimmune Diseases;B-Lymphocytes;Beta Cell;Biocompatible Materials;Biological Assay;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Physiology;chemokine;Clinical;clinical application;Clinical Trials;comparative efficacy;Complement;CTLA4-Ig;cytokine;Cytolysis;Cytoprotection;cytotoxic CD8 T cells;Dendritic Cells;Devices;Diabetes Mellitus;diabetic;effector T cell;efficacy evaluation;Encapsulated;Ensure;euglycemia;Fibrosis;Flow Cytometry;Foreign-Body Reaction;Future;Goals;Graft Rejection;Human;humanized mouse;Hydrogen Bonding;Immune;immune activation;Immune mediated destruction;Immune response;Immune system;Immunofluorescence Immunologic;immunoregulation;Immunosuppression;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Innate Immune Response;insight;Insulin;insulin secretion;Insulin-Dependent Diabetes Mellitus;Interferon alpha;islet;islet allograft;islet amyloid polypeptide;Islets of Langerhans Transplantation;Leucocytic infiltrate;Macrophage;Mediating;Metabolic;mouse model;Mus;Natural Killer Cells;neutrophil;novel;Pathway interactions;Patients;Polymers;Predisposition;preservation;prevent;Reactive Oxygen Species;Research;response;Role;Sampling;scaffold;single-cell RNA sequencing;Site;Skin;Structure of beta Cell of islet;subcutaneous;T cell response;T-Cell Activation;Tannic Acid;Technology;transcriptomics;translational study;Transplantation;Vascularization

PROJECT_TITLE: Islet encapsulation to elicit localized immunosuppression and immune modulation following transplantation

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PI_NAMEs: CLAUS, ELIZABETH B. (contact)

PROJECT_TERMS: Address;Administrator;Advisory Committees;Advocate;Authorization documentation;Behavioral Sciences;Bioethics;Bioethics Consultants;Bioinformatics;Brain Neoplasms;Caregivers;Caring;Client satisfaction;Clinical Management;Clinical Trials;cloud based;Colorado;Communication;Communities;Data;Diagnosis;Disease;Doctor of Philosophy;Education;Epidemiology;Evolution;Excision;Facebook;Gays;Genetic;genetic counselor;Genomic medicine;Genomics;Glioma;Goals;Grant;Health Personnel;Hospitals;implementation science;improved;innovation;Institutional Review Boards;interest;International;Internet;Knowledge;Leadership;Location;Maintenance;Malignant neoplasm of brain;Medical center;Medical Records;meetings;member;Molecular Evolution;Movement;National Cancer Institute;neurosurgery;Occupational activity of managing finances;Office of Administrative Management;Operative Surgical Procedures;organizational structure;Outcome;patient engagement;Patients;Personal Health Records;Persons;Postdoctoral Fellow;Process;Protocols documentation;Recurrence;Registries;repository;Research;Research Assistant;Research Personnel;Resources;Secure;Site;social media;software development;success;Talents;Telephone;Time;Underserved Population;Universities;web site;Woman;World Health Organization;young adult

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: PEDIATRICS

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE This proposal is relevant to public health since Ewing sarcoma (EWS) is the second most common bone tumor of children and treatment remains suboptimal, with survival rates for patients who present without metastatic disease plateaued at 70% and less than 30% for patients who present with metastatic disease. Due to the dose intensity of current standard therapies, patients who survive EWS experience an unacceptable incidence and severity of late effects. The proposed research is highly relevant to the NIH mission, as it seeks to discover new approaches to harness the immune system for the treatment of EWS, which will deliver novel therapeutics for testing in this disease and will also provide generalizable knowledge regarding optimal approaches to develop immunotherapies for low mutational burden cancers.

PI_NAMEs: HEITZENEDER, SABINE ;MACKALL, CRYSTAL  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Address;Adoptive Cell Transfers;Adoptive Transfer;Adult;Affinity;antigen-specific T cells;Antigens;Autoantigens;autologous lymphocytes;bench to bedside;Binding;Binding Proteins;Bone neoplasms;Cancer Burden;cancer cell;Cancer Etiology;candidate identification;checkpoint inhibition;Chemoresistance;chemotherapy;Child;childhood cancer mortality;Childhood Solid Neoplasm;chimeric antigen receptor T cells;comparison control;CRISPR/Cas technology;cross reactivity;Data;Dendritic Cells;Development;Disease;Dose;effector T cell;engineered T cells;Engineering;Ewings sarcoma;exhaustion;experience;fitness;high risk;HLA-A2 Antigen;IGF2 gene;Immune response;Immune system;Immune Targeting;Immune Tolerance;Immunotherapeutic agent;Immunotherapy;immunotherapy trials;improved outcome;Incidence;Individual;interest;Knock-out;Knowledge;Late Effects;Lead;lead candidate;life span;Lipase;Malignant Neoplasms;Mediating;Metastatic/Recurrent;Mission;Mutation;Nature;neoantigens;next generation;Nonmetastatic;Normal tissue morphology;novel;novel strategies;novel therapeutics;Oncogenes;Outcome;overexpression;Patients;Pediatric Neoplasm;Pediatric Oncology;Peptides;postnatal;prevent;Process;Proteins;prototype;Public Health;Quality of life;Recurrence;Regimen;Research;research clinical testing;Resistance;Risk;Safety;Science;screening;Severities;Signal Transduction;Solid;Solid Neoplasm;Survival Rate;Survivors;T cell therapy;T-Cell Receptor;T-Lymphocyte;targeted treatment;Technology;Testing;Therapeutic;therapeutic candidate;therapeutic evaluation;Time;Tissues;Toxic effect;Translating;tumor;Tumor Antigens;Tumor Cell Derivative Vaccine;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Attacking the Immunopeptidome of Ewing Sarcoma


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Patient Safety;Rare Diseases

PROJECT_TERMS: Address;Adult;advocacy organizations;Affect;American;Authorization documentation;Blood;Brain Neoplasms;Clinical;Clinical Trials;cloud based;cohort;Collaborations;Collection;Communication;Communication Tools;Communities;Computer software;Constitution;Consumption;cost;Data;Data Collection;data communication;data sharing;Development;Diagnosis;digital;Disease;Education;Eligibility Determination;Enrollment;Epidemiologic Methods;Epidemiology;Evolution;Excision;flexibility;Funding;Generations;Genomics;Geography;Glioma;Goals;improved;Individual;innovation;International;Knowledge;Learning;Medical Records;member;Methods;middle age;Molecular;Molecular Evolution;Movement;Netherlands;neural network;novel;Online Systems;Operative Surgical Procedures;Outcome;Paraffin Embedding;participant enrollment;Patient advocacy;patient engagement;Patient Recruitments;Patients;Personal Health Records;Persons;Population Heterogeneity;Portraits;Process;Protocols documentation;Rare Diseases;recruit;Recurrence;Recurrent disease;Registries;Research;Research Design;Research Personnel;Resources;Saliva;sample collection;satisfaction;scale up;Secure;social media;Societies;Specimen;success;Survival Rate;Test Result;Testing;Time;tool;tumor;United States;Work

PROJECT_TITLE: Participant Engagement Unit


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases

ORG_DEPT: UROLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Approximately one million transrectal prostate biopsies are performed annually in the U.S., and the risk of post- biopsy infection is increasing due to greater antibiotic resistance of rectal flora. Preliminary data demonstrates that a transperineal MRI-targeted biopsy approach under local anesthesia compared to the standard practice transrectal MRI-targeted prostate biopsy has a much lower risk of infection, comparable pain/discomfort and may improve detection of prostate cancer. Our pivotal randomized controlled trial will be the first prospective study to evaluate in-office transperineal MRI targeted prostate biopsy, and if our hypotheses proves true transperineal MRI-targeted biopsy will become the new standard of care and significantly reduce post-biopsy infections and increase detection of clinically significant prostate cancer.

PI_NAMEs: ALLAF, MOHAMAD ;HU, JIM  (contact);SCHAEFFER, EDWARD MATTHEW

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: accurate diagnosis;Address;Adopted;Adoption;Adverse event;African American;American;Anterior;Antibiotic Prophylaxis;Antibiotic Resistance;antimicrobial;Antimicrobial Resistance;Attenuated;Bacteremia;Bacteria;Bacteriuria;Biopsy;Cancer Detection;Clinic;clinically significant;Collaborations;cost;Data;Detection;Diagnosis;Diffusion;Environment;Equipoise;Evaluation;experience;Funding;General Anesthesia;Guidelines;Hemorrhage;Hospital Costs;Hospitalization;improved;Individual;Infection;infection rate;infection risk;innovation;Lesion;Local anesthesia;Local Anesthetics;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Medicare;men;mortality;Needles;novel;novel strategies;Outcome;outcome disparities;Pain;Patients;Pelvic floor structure;Population Heterogeneity;Prevalence;Procedures;Prophylactic treatment;Prospective Studies;Prostate;prostate biopsy;Public Health;racial disparity;randomized trial;Randomized, Controlled Trials;Rectum;Research;Research Personnel;Risk;Sampling;Screening for Prostate Cancer;Sepsis;Skin;standard of care;stem;Sterility;Techniques;Time;Transrectal Ultrasound;tumor;Ultrasonography;ultrasound;Urinary Retention;Urinary tract

PROJECT_TITLE: Evaluation of Transperineal Biopsy under Local Anesthesia, a Novel approach to Decrease Post-Biopsy Infections and Improve Cancer Detection

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

ORG_CITY: Los Angeles

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative We propose to advance multiscale modeling of biological systems to provide major advances in rational enzyme and drug design, in studying proton transport, charge transport systems, and other key complex molecules. This should help in the fundamental understanding in, and development of, effective drugs to fight diseases associated with defective biological systems.

PI_NAMEs: WARSHEL, ARIEH  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Active Sites;ATP phosphohydrolase;Biochemical Reaction;Biological Process;biological systems;Catalysis;Cells;Charge;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complex;complex biological systems;Computer Assisted;Computer Simulation;Computing Methodologies;Coupled;COVID-19 pandemic;cytochrome c oxidase;design;Development;Directed Molecular Evolution;Disease;Drug Design;Drug resistance;Electrodes;Electrolytes;Electron Transport;Entropy;Enzymes;Experimental Designs;experimental group;experimental study;fighting;Free Energy;G-Protein-Coupled Receptors;Grain;improved;Ion Channel Gating;Ions;Life;Medical;Membrane;Methods;Microscopic;Modeling;Molecular;multi-scale modeling;Pharmaceutical Preparations;Process;Proteins;Protons;screening;simulation;Structure;Surface;System;trend;voltage

PROJECT_TITLE: Multiscale Simulations of Biological Systems and Processes

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Rural Health;Social Determinants of Health

PI_NAMEs: WATANABE-GALLOWAY, SHINOBU  (contact)

PROJECT_TERMS: Address;African American population;anti-cancer research;Area;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer education;cancer health disparity;Catchment Area;Cause of Death;Centers for Disease Control and Prevention (U.S.);Clinical;Clinical Trials;college;Communities;community advisory board;community engagement;Community Outreach;community partners;community partnership;Conduct Clinical Trials;County;Coupled;Death Rate;demographics;Department chair;Development;Disparity;Doctor of Philosophy;Education;Educational Activities;Ensure;Epidemiology;ethnic minority population;Ethnic Origin;evidence base;experience;Face;Faculty;forging;frontier;frontier counties;Funding;Future;Geography;Goals;Government;Health;health care availability;Health Disparities Research;Health Promotion;Healthcare;human old age (65+);Human Resources;Improve Access;Incidence;Infrastructure;Lead;Leadership;Malignant Neoplasms;Measurement;Measures;Medical center;meetings;member;Modeling;Monitor;mortality;Native Americans;NCI Center for Cancer Research;Nebraska;Needs Assessment;outreach;patient navigator;Persons;Play;Policies;policy recommendation;Population;Population Group;Population Heterogeneity;Prevention;professor;programs;Public Health;Public Health Practice;Race;racial diversity;racial minority population;recruit;Reduce health disparities;Research;Research Personnel;Risk Factors;Rural;Rural Community;rural counties;Rural Health Centers;Science;Screening for cancer;Time;Translations;trend;underserved community;Universities;Urban Population;Work

PROJECT_TITLE: Community Outreach and Engagement


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: MAYWOOD

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

ORG_STATE: IL

PHR: Project Narrative This work will establish that reduction in SELENOF levels is an underlying biological factor contributing to racial disparity in breast cancer, and thus supports the development of SELENOF-based therapeutics. Successful completion of pre-clinical studies on two different therapeutic strategies investigated here may result in personalized and more effective therapy options for African American patients affected by low SELENOF. SELENOF polymorphisms and protein levels can be developed into biomarkers to identify African American patients at risk of lethal breast cancer disease.

PI_NAMEs: KASTRATI, IRIDA  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: 3' Untranslated Regions;Acceleration;Address;Affect;Affinity;African American;African American population;African American Women;aggressive breast cancer;Automobile Driving;Binding;Biological Factors;Biological Markers;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;Breast Epithelial Cells;breast tumorigenesis;cancer genome;candidate marker;Caucasians;Cell Death;Cell Death Induction;cell growth;Cell Line;Cell Survival;Cells;Clinic;Clinical;Data;Dependence;Development;dimethylbenzanthracene;Disease;Disease Progression;disparity gap;DNA;effective therapy;Enzymes;Eukaryotic Initiation Factors;Frequencies;Genetic Polymorphism;Genome;Immunocompetent;In Vitro;in vitro Assay;in vivo;in vivo Model;Incidence;inhibitor;Inositol;Knockout Mice;Malignant Breast Neoplasm;Mammary Neoplasms;Mammary Tumorigenesis;Measures;Messenger RNA;metaplastic cell transformation;Modeling;mortality;mouse model;mRNA Expression;Mutation;novel;novel therapeutic intervention;Oncogenic;Outcome;overexpression;Oxidoreductase;Pathway interactions;Patient-Focused Outcomes;Patients;personalized medicine;pharmacologic;Phenocopy;Phenotype;Phosphotransferases;Pre-Clinical Model;preclinical study;Predisposition;Proliferating;Proteins;Race;racial disparity;Regulation;Reporter;Repression;response;Ribonucleases;Risk;RNA;Sampling;Selenocysteine;selenoprotein;Single Nucleotide Polymorphism;SNP genotyping;Stains;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;three dimensional cell culture;transcription factor;Translational Repression;Translations;Treatment Efficacy;treatment response;tumor;tumor DNA;tumor growth;tumor progression;Tumor Suppressor Proteins;tumorigenesis;Variant;White Women;Work;XBP1 gene;Xenograft Model;Xenograft procedure

PROJECT_TITLE: SELENOF is a Novel Tumor Suppressor and a New Target to Overcome Racial Disparity in Breast Cancer.

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


PHR: Project Narrative: Overall The overall goal of the National Center for Engagement in Diabetes Equity Research: National CEDER is to strengthen the engagement of communities and individuals from diverse backgrounds and sectors in type 2 diabetes (T2D) research across the research spectrum and the United States. National CEDER will achieve this goal by 1) creating a centralized, national network infrastructure, 2) creating a partnership hub model that will inform T2D research priorities and methods, 3) developing a robust studio and consultancy model rooted in bi- directional capacity building and co-leadership, and 4) collaborating to disseminate best practices and lessons learned. National CEDER is an expansive partnership consisting of 18 schools of public health, schools of medicine, and minority-serving institutions; and 10 regional and national community based organizations reaching diverse African American, Latinx, Asian American, Native Hawaiian, Pacific Islander, and American Indian/Alaska Native communities, geographic areas, and communities facing historical marginalization.

PI_NAMEs: BROWN, ARLEEN F.;CHAMBERS, EARLE C;ISLAM, NADIA S (contact)

PROGRAM_OFFICER_NAME: RAJAPAKSE, NISHADI

PROJECT_TERMS: Acceleration;Address;African American;Age;Alaska Native;American;American Indians;Asian Americans;Asian population;Behavior;Black Populations;Central American;Chinese;Collaborations;college;Communities;community engagement;community organizations;Compensation;Complications of Diabetes Mellitus;Consultations;Data;design;Diabetes Mellitus;Discipline;Disparity;Dissemination and Implementation;Dominican;Equity;ethnic minority;Ethnic Origin;Ethnic Population;Federally Qualified Health Center;Filipino;Fostering;Gender;Gender Identity;Geographic Locations;Geography;Goals;Health;health equity;Healthcare;Hospitals;implementation science;improved;Individual;Inequity;Institution;Institutional Racism;interdisciplinary collaboration;intersectionality;Intervention;Latino Population;Latinx;Lead;Leadership;Life Cycle Stages;Lived experience;low socioeconomic status;marginalization;medical schools;Medicine;Methods;Mexican;minority communities;Minority-Serving Institution;Modeling;Municipalities;Muslim religion;Native Hawaiian or Other Pacific Islander;Nature;Network Infrastructure;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;operation;Outcome;Persons;Pima Indian;Population;Process;Public Health Schools;public-private partnership;Puerto Rican;Race;racial minority;racism;real world application;Research;Research Methodology;Research Personnel;Research Priority;Resource-limited setting;Resources;rural area;Services;Shapes;social health determinants;South Asian;Structural Racism;Structure;success;System;Translational Research;trustworthiness;United States;uptake;Vision;Work


NIH_SPENDING_CATS: Cancer

PI_NAMEs: CLAUS, ELIZABETH B. (contact);KWAN, BETHANY MATTHEWS;VERHAAK, ROEL GW

PROJECT_TITLE: Genome Characterization Unit


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health

ORG_CITY: RAPID CITY

ORG_NAME: BLACK HILLS CTR/AMERICAN INDIAN HEALTH

PHR: The Lakota Center for Health Research NARCH program will continue to build culturally-relevant research capacity and support for the 3 major Lakota Sioux Tribes in South Dakota, who are partners in this effort.

PI_NAMEs: HENDERSON, JEFFREY A (contact)

PROJECT_TERMS: Adherence;Administrator;Agreement;Alaska Native;American Indians;Area;Black race;career development;Cheyenne;Cities;cloud based;Communication;Communities;Compensation;Data;design;Doctor of Medicine;effectiveness evaluation;Enrollment;Ensure;Environment;Epidemiologist;Evaluation;Expenditure;experience;Faculty;Funding;Funding Opportunities;Guidelines;Head;Health;health inequalities;Human Resources;Individual;innovation;Institutional Review Boards;Internist;Leadership;Master of Public Health;meetings;member;Monitor;Native American Research Center for Health;operation;Participant;Performance;Persons;phrases;Planet Earth;Policies;Preparation;Principal Investigator;Procedures;Program Research Project Grants;programs;Progress Reports;Publications;Recommendation;Reporting;Research;research and development;Research Project Grants;Research Support;response;Schedule;Scientist;Sioux Indians;South Dakota;Technology;Teton Sioux Indian;tribal health;tribal member;Tribes;United States National Institutes of Health;verbal;web site;Work;Writing;Youth

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BDCN-N]


NIH_SPENDING_CATS: American Indian or Alaska Native;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Mental Health;Post-Traumatic Stress Disorder (PTSD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health;Violence Against Women;Violence Research;Women's Health Research

PHR: Using a highly participatory approach, this study will assess the feasibility, acceptability, and satisfaction with a culturally tailored, trauma-informed smoking cessation intervention for Northern Plains Tribal women who have experienced intimate partner violence. If successful, other American Indian Tribes and Tribal communities can adapt this innovative smoking cessation curriculum for their communities.

PI_NAMEs: HENDERSON, PATRICIA NEZ (contact)

PROJECT_TERMS: addiction;Addictive Behavior;Address;Age;Alcohol consumption;American Indian Tribe;American Indian Women;American Indians;Anxiety;Awareness;Behavior;behavior change;Biochemical;Black race;Cardiovascular Diseases;Cause of Death;Cessation of life;Choices and Control;cigarette smoking;Circulation;Cities;Communities;community advisory board;community based participatory approach;community partners;Coupled;craving;Data;Death Rate;Development;Drug usage;Educational Curriculum;Effectiveness of Interventions;Emotional;environmental tobacco smoke exposure;Ethnic Population;experience;Family member;flexibility;follow-up;Goals;Health;Health Benefit;High Prevalence;high risk population;improved;Individual;innovation;Intervention;intervention refinement;intimate partner violence;Knowledge;Malignant neoplasm of lung;Manuals;Mental Depression;Mental Health;Methodology;mindfulness;Mindfulness Training;Modeling;Morbidity - disease rate;Myocardial Infarction;Nicotine Dependence;Northern Plains Tribe;novel;Outcome Study;Pattern;physical conditioning;Population;Post-Traumatic Stress Disorders;premature;Prevalence;programs;psychologic;Public Health;racial population;Research;Research Support;resilience;Respiratory physiology;response;Risk;Risk Factors;Safety;satisfaction;Severities;Smoker;Smoking;smoking abstinence;smoking cessation;Smoking Cessation Intervention;smoking prevalence;Stroke;substance use;Testing;Teton Sioux Indian;therapy development;Tobacco;Training;Trauma;treatment arm;trial enrollment;tribal community;Woman;Women's prevalence

PROJECT_TITLE: Smoking Cessation Intervention for American Indian Women Experiencing Intimate Partner Violence


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Data Science;Digestive Diseases;Liver Cancer;Liver Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE The proposed study is highly relevant to public health because early detection has great potential to reduce liver cancer burden in United States and worldwide. Rigorous evaluation of biomarker tests for their potential clinical utility is imperative for public health.

PI_NAMEs: FENG, ZIDING  (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: Address;anti-cancer research;Artificial Intelligence;artificial intelligence method;Bioinformatics;Biological Markers;Biological Specimen Banks;Biological Specimen database;biomarker evaluation;Biometry;cancer biomarkers;Cancer Burden;Cancer Center;Cancer Detection;Center for Translational Science Activities;Cirrhosis;Clinical;Clinical Data;Cohort Studies;Collaborations;Collection;Common Data Element;Communication;computational intelligence;Computer Analysis;computerized data processing;Consultations;Country;Dana-Farber Cancer Institute;Data;Data Collection;Data Coordinating Center;data management;Data Management Resources;data repository;Data Science;Data Set;data sharing;Databases;Discipline;Early Detection Research Network;Early Diagnosis;Ensure;Evaluation;Evaluation Studies;experience;Image;improved;informatics tool;Information Technology;Infrastructure;innovation;instrument;Lead;Leadership;Liver;Malignant neoplasm of liver;Malignant Neoplasms;Manuals;meetings;Mission;Modeling;Monitor;Nodule;operation;Output;Patients;Procedures;programs;Prospective Studies;Prospective, cohort study;protocol development;Protocols documentation;Public Health;Qualifying;Randomized;Research;Research Design;Research Personnel;research study;Research Support;Retrospective Studies;Risk;risk stratification;Sampling;Science;Scientist;Screening for Hepatocellular Cancer;Secure;Services;Specimen;Statistical Data Interpretation;Statistical Methods;success;symposium;System;Testing;Time;Translational Research;United States;University of Texas M D Anderson Cancer Center;validation studies;web site;Work

PROJECT_TITLE: Consortium on Translational Research in Early Detection of Liver Cancer:Data Management and Coordinating Center (DMCC)


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Rehabilitation;Serious Mental Illness

ORG_DEPT: PSYCHIATRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Cognitive behavioral therapy with exposure and response prevention is highly effective for children with OCD, yet not all children will fully remit. Exposure therapy requires leveraging extensive cognitive control, which is shown to be altered in youth with OCD. This project will leverage a child-friendly, computerized, at-home cognitive training program in 8–12-year-olds with OCD to enhance the capacity for cognitive control (target engagement) and augment response to exposure therapy.

PI_NAMEs: FITZGERALD, KATE DIMOND;MARSH, RACHEL  (contact);PAGLIACCIO, DAVID

PROGRAM_OFFICER_NAME: GARVEY, MARJORIE ANN

PROJECT_TERMS: 12 year old;Address;Adherence;Attention deficit hyperactivity disorder;Behavior;Behavioral;Brain;Child;Childhood;Cognition;Cognitive;cognitive capacity;cognitive control;cognitive enhancement;cognitive performance;cognitive system;cognitive task;Cognitive Therapy;cognitive training;computerized;Data;Development;Disease remission;Distress;dosage;Dose;Double-Blind Method;Early Intervention;Educational Intervention;Elements;Ensure;experience;Exposure to;FDA approved;flexibility;Friends;Fright;functional outcomes;Goals;Home;Hour;improved;indexing;Intervention;Investigational Therapies;Literature;Manuals;Mediating;MRI Scans;National Institute of Mental Health;neural;neuromechanism;Neurosciences;novel;Obsession;Obsessive-Compulsive Disorder;Parents;Participant;Patient Self-Report;Patients;pediatric patients;Persons;Phase;Play;Population;Prevention;Process;Protocols documentation;Randomized;Randomized, Controlled Trials;reduce symptoms;remote monitoring;Research Domain Criteria;response;Rest;Risk;Ritual compulsion;symptomatic improvement;Symptoms;System;Testing;Theoretical model;Thinking;Training;Training Programs;United States National Institutes of Health;Work;Youth

PROJECT_TITLE: Cognitive control targets for the treatment of obsessive compulsive disorder in young children


PI_NAMEs: COWAN, KENNETH H. (contact)

PROJECT_TERMS: Address;Advisory Committees;anti-cancer research;Area;authority;Basic Science;Cancer Burden;cancer care;Cancer Care Facilities;Cancer Center;Cancer Center Support Grant;cancer education;cancer health disparity;cancer research center director;Catchment Area;Clinical;clinical care;Clinical Research;Clinical Trials;Collaborations;Communities;community advisory board;community engagement;Community Outreach;community partners;Consultations;Development;Disparity;Ensure;Evaluation;Faculty;Feedback;Foundations;Funding;Future;Goals;Growth;Healthcare;Hospitals;improved;innovation;Institution;interdisciplinary collaboration;Leadership;Malignant Neoplasms;Medicine;member;Mission;NCI-Designated Cancer Center;Nebraska;Nursing Faculty;Outcome;patient oriented;Periodicals;Physicians;Positioning Attribute;Process;programs;recruit;Reporting;Research;research faculty;Research Infrastructure;Research Priority;Resource Sharing;Resources;Scientific Advances and Accomplishments;Services;Strategic Planning;Students;Surveys;Teacher Professional Development;Technology;Training and Education;translational cancer research;Translational Research;Universities;Vision;Work

PROJECT_TITLE: Leadership, Planning and Evaluation


NIH_SPENDING_CATS: American Indian or Alaska Native;Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PHR: The implementation of a 15-community wastewater treatment testing program on the CRST Reservation will increase the Tribe’s surveillance capacity in very important ways, such as the introduction, trajectory, and origin of new infectious disease cases, including SARS-CoV-2. This project will also help to inform knowledge gaps regarding virus subtypes within this Tribal community, and whether this type of testing can be feasibly implemented in relatively low-density settings.

PROJECT_TERMS: 2019-nCoV;Address;Affect;Alaska Native;American Indians;Attitude;Behavioral;Businesses;Cessation of life;Cheyenne;Chronic;Clinical Data;Color;Communicable Diseases;Communities;Coronavirus;COVID-19;COVID-19 pandemic;COVID-19 prevention;COVID-19 surveillance;Crowding;density;design;Detection;Diagnostic Reagent Kits;Disease;Disease Outbreaks;Disease Surveillance;effectiveness evaluation;Emergency response;Environmental Impact;Environmental Monitoring;Epidemic;epidemiologic data;Equation;Ethics;Ethnic Population;experience;frontier;Funding;Future;Goals;Health;Housing;Incidence;Indian reservation;Inequity;Infectious Agent;Infrastructure;Knowledge;Mind;multidisciplinary;Northern Plains;Northern Plains Tribe;novel coronavirus;pandemic disease;pandemic impact;personal protective equipment;Poverty;Prevention strategy;Process;programs;public health emergency;Qualitative Methods;racial population;Research;Research Personnel;Reservations;Resources;Running;Rural;Schools;screening;Sioux Indians;Smallpox;social;South Dakota;Spanish flu;Speed;Surveillance Program;System;Testing;Teton Sioux Indian;Thinking;Travel;tribal community;tribal leader;tribal member;Tribes;United States;United States Indian Health Service;US State;Viral;viral outbreak;Virus;wastewater surveillance;wastewater testing

PROJECT_TITLE: Strengthening COVID-19 prevention strategies via wastewater surveillance in a Northern Plains Tribe


ORG_CITY: JACKSON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: PROJECT NARRATIVE The Mississippi Center for Clinical and Translational Research (MCCTR) has developed the first ever multidisciplinary and institutional program in Mississippi that combines efforts of basic, clinical and population scientists and the community. During Phase II, we propose to facilitate clinical and translational research projects in racial/ethnic health disparities, rural health, and telehealth strategies focused on improving the health of Mississippians. This critical goal will be achieved by expanding, enhancing and adding greater value to clinical and translational research in our state via innovative approaches that emphasizes growth in rural and health disparities, telemedicine and implementation research.

PI_NAMEs: GRANGER, JOEY P. (contact)

PROGRAM_OFFICER_NAME: BISSONETTE, GREG

PROJECT_TERMS: Academic Medical Centers;Address;Adult;Advisory Committees;African American population;Alabama;Area;Behavior Therapy;Biomedical Research;Biometry;Black race;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;Cause of Death;Center for Translational Science Activities;Cessation of life;Child;Clinic;Clinical;clinical care;clinical center;clinical implementation;Clinical Research;Clinical Sciences;Cohort Studies;Collaborations;college;Communicable Diseases;Communication;Communities;community advisory board;community engaged research;community engagement;Community Outreach;Data Collection;data management;data warehouse;Development;Diabetes Mellitus;Diagnosis;Disease;Disparity;economic disparity;Effectiveness;electronic data;Epidemiology;ethnic health disparity;Evaluation;Extramural Activities;Faculty;Fostering;Foundations;Funding;Goals;Growth;Health;Health Disparities Research;health disparity;Health Personnel;Health Services Accessibility;Human Resources;implementation research;implementation science;improved;Income;Infant Mortality;Infrastructure;innovation;Institution;Interdisciplinary Study;Leadership;Louisiana;Low Birth Weight Infant;Marketing;Medical center;member;Mentors;Mentorship;Mississippi;Modernization;multidisciplinary;National Institute of General Medical Sciences;Obesity;Obesity associated disease;Office of Administrative Management;Outcome;outreach;Outreach Research;Performance;Persons;Phase;physical inactivity;Pilot Projects;Population;Population Research;Poverty;practice-based research network;programs;racial disparity;racial health disparity;recruit;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Resources;Rural;Rural Community;rural disparities;Rural Health;Scientist;Services;Statistical Data Interpretation;statistics;Structure;success;telehealth;Telemedicine;Time;tool;Training;training opportunity;translational engagement;Translational Research;translational research program;Universities;Urban Community;Work


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PI_NAMEs: VICKERS, SELWYN M (contact)

PROJECT_TERMS: Area;Arts;Biology;Biomedical Research;candidate selection;Cardiovascular Diseases;cohort;Collaborations;college;Communication;Communities;Decision Making;Development;Diabetes Mellitus;diversity and inclusion;Doctor of Philosophy;Ensure;Environment;environmental change;Equity;Faculty;Funding;Goals;Health Disparities Research;health disparity;Health Occupations;Health Services;Human Resources;improved;Infrastructure;Institution;Intervention;Interview;Leadership;Maintenance;Malignant Neoplasms;medical schools;Medicine;member;mid-career faculty;minority health;minority health disparity;Modeling;Neurosciences;Obesity;organizational climate;Personnel Management;Physician Executives;Policies;Positioning Attribute;Preventive Medicine;Process;professor;programs;Protocols documentation;Public Health;recruit;Reporting;Research;Resources;School Nursing;Science;Scientist;Secure;social;Strategic Planning;success;System;United States National Institutes of Health;Universities;Wages;web site

PROJECT_TITLE: UAB/TU FIRST Administrative Core


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences;Pediatric

ORG_CITY: BLOOMINGTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative The proposed studies of the visual experience of infants are relevant to public health because impaired vision and visual learning have long term consequences across many domains of a healthy and successful life. Disrupted visual experience in infancy is evident in the continued risk in perceptual, cognitive and school achievements and is implicated in the nexus of disrupted visual learning and motor development of children with more general developmental disorders. Determining the expected and normative early visual input in infancy and its links to infant eye- movements and behaviors is expected to give rise to new diagnostics and behavioral interventions for at-risk infants.

PI_NAMEs: SMITH, LINDA B. (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Achievement;Age;Age Months;Anisometropia;Behavior;behavior change;behavior influence;Behavior Therapy;Birth;Cataract;Characteristics;Child Development;Cognition;Cognitive;Color;Development;developmental disease;early experience;Educational Curriculum;Esthesia;experience;Eye;Eye Movements;Face;falls;Frequencies;gaze;Goals;Hand;Hand functions;Head;Head Movements;Health;Home;Hour;Human;Image;infancy;Infant;Infant Behavior;interest;Laboratories;Laboratory Study;large datasets;Life;Link;Literature;Measures;Motion;motion sensor;Motor;Movement;novel;novel diagnostics;Outcome;Pattern;Persons;Play;Positioning Attribute;postnatal;Posture;preference;Property;Ptosis;Public Health;Refractive Errors;Research;Retina;Risk;Role;Sampling;Schools;Semantics;Series;statistics;Strabismus;Structure;Testing;Vision;vision development;Visual;Visual Cortex;Visual impairment;visual information;visual learning;visual motor;Visual System;visual tracking;Work

PROJECT_TITLE: The Statistics of Infant First-Person Visual Experience

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Serious Mental Illness

PHR: PROJECT NARRATIVE The proposed research project aims to characterize the neural effects of psilocybin in the treatment of obsessive-compulsive disorder (OCD), in a randomized fashion, with the focus on default mode network and corticostriatal circuit. The results from this study may shed light on the neurobiology of OCD and potentially lead to the development of novel treatments, which will allow us to stratify patients to appropriate treatments.

PI_NAMEs: KELMENDI, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: active control;Acute;addiction;Adverse effects;Affect;Aftercare;Algorithms;Anxiety;Anxiety Disorders;base;Behavioral;Belief;Brain;brain surgery;career;career development;Clinical;clinical effect;clinical investigation;Clinical Research;clinical training;clinical translation;Clinical Trials;Clinical Trials Design;Corpus striatum structure;Data;Dedications;Development;Development Plans;Disabling;Disease;Dose;drug development;Ethics;Evaluation;experience;Functional Magnetic Resonance Imaging;Funding;Goals;Grant;Hallucinogens;Hour;improved;individualized medicine;innovation;insight;Institution;Intervention;Intoxication;Investigational Therapies;K-Series Research Career Programs;Maps;Mental disorders;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Mood Disorders;Moods;neural;neural correlate;Neurobiology;neuroimaging;Neurons;neuropsychiatric disorder;Neurosciences;Nicotinic Acids;novel;Obsessive-Compulsive Disorder;Paper;Participant;Patient Care;patient stratification;Patients;Pharmaceutical Preparations;Pharmacologic Actions;Physicians;Placebo Control;placebo controlled study;Population;Positioning Attribute;precision medicine;predicting response;Prediction of Response to Therapy;Psilocybin;Psychiatrist;Psychiatry;Psychotherapy;Randomized;randomized, controlled study;Refractory;Reporting;Research;Research Project Grants;Research Training;Residual state;Rest;Scientist;success;symptomatic improvement;symptomatology;Symptoms;Testing;Therapeutic;Therapeutic Effect;Therapeutic Intervention;Time;Training;translational neuroscience;treatment responders;treatment strategy;Work;Writing

PROJECT_TITLE: The neural correlates of the effects of psilocybin in OCD: randomized controlled study

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


PROJECT_TERMS: anti-cancer research;authority;base;Cancer Biology;Cancer Center;Cancer Center Support Grant;Collaborations;college;cost;Dentistry;Department chair;Development;Discipline of Nursing;Ensure;Evaluation;Faculty;Faculty Recruitment;Financial Support;Funding;Goals;interdisciplinary collaboration;Link;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Medicine;member;NCI Center for Cancer Research;Peer Review;Pharmacy facility;programs;Public Health;recruit;Research;Research Personnel;Strategic Planning;success

PROJECT_TITLE: Developmental Funds


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: TUCSON

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE The long-range goal of the “Building a Culture of Health and Action” Project is to create a national deep engagement learning model of Science, Technology, Engineering, Arts and Math (STEAM) education that engages 8th - 12th graders and provides them with the tools, skills and support to document, reflect upon, and communicate issues of concern (through an advisory board and Photovoice); collect soil and dust samples (through co-created citizen/community science); and make sense of data so that their results can inform actions at the local, regional, and even national level (through data visualization and environmental communication). The proposed educational program is focused on social determinants of health and environmental health in rural, medically underserved communities in Arizona that neighbor resource extraction. In the context of learning, environmental health education objectives include understanding: (1) how advisory boards can foster the development of critical thinking and communication skills; (2) how a summer certification program can increase environmental health literacy (EHL); (3) how an equity-centered community design approach to data sharing strategies can build a participant’s EHL; and (4) how to successfully broaden participation in STEAM learning by historically underrepresented individuals living in environmentally compromised spaces.

PI_NAMEs: RAMIREZ-ANDREOTTA, MONICA D. (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Address;Adult;Adult women;Affect;age group;Agriculture;Air;Area;Aridity;Arizona;Arts;Asthma;broadening participation research;certificate program;Certification;climate change;climate impact;Collaborations;college;Communication;Communities;community advisory board;community building;community science;Complex;County;Critical Thinking;cultural health;Data;Data Collection;data literacy;data sharing;data visualization;Decision Making;Democracy;design;Development;Disparity;Dust;Ecosystem;Education;education research;empowerment;Engineering;Environment;Environmental Hazards;Environmental Health;Environmental Impact;environmental justice;Environmental Monitoring;Environmental Pollution;Environmental Risk Factor;Environmental Science;Environmental Wind;Equity;evidence base;Exposure to;Fostering;Future;Goals;hazard;Health;health determinants;Health education;health equity;Health Hazards;health literacy;high school;Incidence;Individual;Inhalation;instrument;Internet;intersectionality;Justice;Knowledge;Laboratories;Lead;Learning;learning engagement;mathematical learning;Mathematics;medically underserved;member;Metals;Modeling;Motivation;Outcome;Participant;Policies;Population;Poverty;Preparation;prevention practice;Process;programs;Protocols documentation;Public Participation;Recommendation;Research;Research Personnel;Resources;Risk;Rural;rural counties;rural health disparities;Rural Population;rural underserved;rurality;Sampling;Science;science education;Scientific Inquiry;Scientist;Self Efficacy;skills;social factors;social health determinants;Social Justice;Soil;Students;teacher;Technology;tool;toxicant;twelfth grade;Underrepresented Populations;underserved community;urban area;Visual;Vulnerable Populations;Work;Youth

PROJECT_TITLE: Building a culture of health in the green: Participatory learning and action to address air and soil quality in rural underserved communities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: INDIANAPOLIS

ORG_DEPT: GENETICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: Narrative Neuroinflammation has been associated with a variety of neurodegenerative diseases, but the pathology of neuroinflammation in glaucoma is unique due to the highly localized nature of glial reactivity in the optic nerve head as RGC axons exit the eye, correlated with the initial site of injury along RGC axons. While animal models have demonstrated the contributions of neuroinflammation to the pathology of glaucoma, important differences exist between animal models and human patients, including low conservation of RGCs as well as numerous functional differences in glia. Thus, to better recapitulate interactions between RGCs and glia in glaucoma, the current application leverages human pluripotent stem cell-derived retinal ganglion cells, astrocytes, and microglia in a robust and reproducible in vitro microfluidic platform that recreates the spatial interactions of glia upon human RGC axons relevant to the neuroinflammatory phenotypes observed in glaucoma.

PI_NAMEs: MEYER, JASON STEPHEN (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Address;Adopted;Affect;Animal Model;Astrocytes;Axon;Axonal Transport;Blindness;Brain;Cell Compartmentation;Cell Differentiation process;Cell model;cell type;Cells;Central Nervous System;Coculture Techniques;Dendrites;Development;Disease;Disease Progression;Ensure;Eye;Gene Expression Profile;Genetic Transcription;Glaucoma;Health;Human;human model;human pluripotent stem cell;In Vitro;in vitro Model;Injury;Label;Length;Microfluidics;Microglia;Modeling;Morphology;Mutation;Nature;Nerve Degeneration;Neurodegenerative Disorders;neurodegenerative phenotype;Neuroglia;neuroinflammation;neuron development;Neurons;neurotoxic;neurotoxicity;novel;novel therapeutic intervention;Optic Disk;Optic Nerve;patch clamp;Pathology;Pathway interactions;Patients;Phenotype;Play;real-time images;Reproducibility;Retina;retinal axon;retinal ganglion cell degeneration;Retinal Ganglion Cells;retinal neuron;Role;Signal Pathway;Site;stem cell model;Study models;success;System;Testing;Thalamic structure;transcriptome sequencing;transmission process;visual information

PROJECT_TITLE: Establishing a human cellular model of retinal ganglion cell compartmentalization in neurodegeneration and neuroinflammation


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: FOUAD, MONA N. (contact)

PROJECT_TERMS: Address;Advocate;Affect;Area;career;career development;cohort;Collaborations;collaboratory;Common Data Element;Communities;community building;community engagement;community organizations;Dedications;design;Development;Development Plans;diversity and inclusion;Education;Ensure;Environment;Equipment;Equity;equity, diversity, and inclusion;Ethics;Evaluation;Faculty;Funding;Future;Goals;Grant;health disparity;Individual;Infrastructure;innovation;Institution;Institutional Policy;Lead;Manuscripts;member;men;Mentors;minority scientist;Modeling;multidisciplinary;Outcome;peer;Policies;programs;recruit;Research;Research Infrastructure;Research Personnel;Research Support;Science;Scientist;social;success;Teacher Professional Development;Underrepresented Minority;United States National Institutes of Health;virtual;Woman;Work;Writing

PROJECT_TITLE: UAB/TU FIRST Faculty Development Core


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety

PI_NAMEs: GANTI, APAR KISHOR  (contact)

PROJECT_TERMS: Adherence;Amendment;anti-cancer research;Area;Awareness;cancer care;Cancer Center;Cancer Center Support Grant;cancer clinical trial;cancer therapy;Caring;Case Report Form;Catchment Area;Child;Clinical;Clinical Data;Clinical Protocols;Clinical Research;clinical trial implementation;Clinical Trials;Data;data management;Data Reporting;Development;Disease;Education;electronic data;Electronics;Enrollment;Ensure;Frequencies;Guidelines;Industry;Institution;investigator-initiated trial;Malignant Neoplasms;member;metropolitan;Minority Groups;Mission;Monitor;Monitoring Clinical Trials;National Clinical Trials Network;Nebraska;Office Management;participant safety;Pediatric Oncology Group;Phase;Population;Population Sciences;Procedures;process improvement;programs;protocol development;Protocols documentation;quality assurance;Recommendation;recruit;Regulation;Reporting;Research;Research Personnel;research study;Research Support;Resources;Review Committee;Rural Population;Safety;screening;Serious Adverse Event;Site;System;Training and Education;Underserved Population;Woman

PROJECT_TITLE: Clinical Protocol and Data Management


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: MADISON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Complex patients with chronic health conditions are much more likely to experience medication errors, poor healthcare outcomes, and higher healthcare costs compared to people with shorter-term or fewer health ailments. This study seeks to conceptualize, design, implement, and test a Medication Safety Map for the community pharmacy setting to enhance pharmacists’ and technicians’ abilities to either avoid, or to quickly identify and recover from, medication errors before patient safety is endangered. The Medication Safety Map is an innovative approach that will be used by pharmacists and pharmacy technicians to better navigate the complex tasks in the pharmacy, and to facilitate communication with both patients and clinicians, while safely providing medications to complex patients with chronic health conditions.

PI_NAMEs: CHUI, MICHELLE ANNE (contact);FORD, JAMES H

PROGRAM_OFFICER_NAME: SAMAD, FARZANA

PROJECT_TITLE: Engineering Resilient Community Pharmacies (ENRICH)

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Primary Health Care

ORG_CITY: WINSTON-SALEM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Narrative The high prevalence of multiple chronic conditions (MCCs) and geriatric syndromes among older adults make it difficult to diagnose Alzheimer’s disease and related dementias (ADRD); biomarkers may enhance diagnosis, but many questions remain regarding accuracy and utility of these biomarkers in primary care for prognosis, patient preference, disclosure, and ethical considerations. The overall goal of the Alzheimer’s Diagnosis in older Adults with Chronic Conditions (ADACC) Network is to establish a national consortium consisting of multi- disciplinary and multi-site investigators that will develop evidence-backed strategies for the use, interpretation, and implementation of biomarkers for the diagnosis of ADRD in older patients with MCCs. The network will include existing diverse observational and real-world cohorts, a Steering Committee, Data Coordinating Center, and working groups; will fund three pilot projects each year; and convene an annual meeting.

PI_NAMEs: FOWLER, NICOLE R.;KARIKARI, THOMAS K;MIELKE, MICHELLE M (contact);WILLIAMSON, JEFF DOUGLAS

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: accurate diagnosis;Affect;Age;age related biomarkers;Algorithms;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Biological Assay;Biological Markers;biomarker performance;Blood;blood-based biomarker;Caregivers;Caring;Chronic;Chronic Kidney Failure;Clinical;clinical care;clinical decision-making;cognitive function;cohort;Collection;Communication;cost;Cost Analysis;cost effective;cost estimate;Counseling;Data Coordinating Center;Development;Diagnosis;diagnostic accuracy;diagnostic algorithm;Disclosure;Disease;Disease Progression;Elderly;Ethics;Ethnic Origin;Etiology;frailty;Funding;Goals;Grant;Guidelines;High Prevalence;Image;Impaired cognition;Incidental Findings;Insurance Coverage;Life;Life Expectancy;Light;Medicare;meetings;Modeling;multidisciplinary;multiple chronic conditions;neurofilament;neuropathology;Normal Range;Obesity;older adult;older patient;Pathology;Pathway interactions;patient population;Patient Preferences;Patients;Performance;personalized care;Pharmaceutical Preparations;Physiological;Pilot Projects;Polypharmacy;Population;Population Heterogeneity;Positron-Emission Tomography;pragmatic trial;predictive marker;Primary Care;Primary Health Care;Procedures;Prognosis;Provider;Race;Recommendation;Reference Values;Research;Research Personnel;Risk;risk/benefit ratio;screening program;Service delivery model;sex;Site;Socioeconomic Status;Specialist;Subgroup;Syndrome;tau Proteins;tau-1;Testing;Time;working group

PROJECT_TITLE: Alzheimer Diagnosis in older Adults with Chronic Conditions ADACC Network


NIH_SPENDING_CATS: Cancer;Patient Safety;Prevention

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

PROJECT_TERMS: Amendment;authority;behavioral study;Biometry;Cancer Center;Cancer Center Support Grant;cancer prevention;cancer therapy;Caring;Charge;Clinical Cancer Center;Clinical Research;Clinical Sciences;Clinical Trials;Collection;Committee Members;Data;Detection;Development;Diagnosis;Discipline of Nursing;Disease;Enrollment;Ensure;expedited review;Faculty;falls;Feasibility Studies;Feedback;Hematologic Neoplasms;human subject;innovation;Institution;Institutional Review Boards;Intervention Trial;Lead;Logistics;Longterm Follow-up;Malignant Neoplasms;Medical center;Medical Oncology;member;Modification;Monitor;multidisciplinary;Nebraska;Oncology;Pathology;Patient Outcomes Assessments;patient safety;Patients;Pediatric Oncology;Peer Review;Pharmacology;Population;Population Sciences;Prevention;Principal Investigator;Process;Protocols documentation;Qualifying;Quality of life;Radiation Oncology;Recommendation;Regulation;Research;Research Activity;Research Personnel;Review Committee;Safety;screening;Site;Solid Neoplasm;sound;Students;Suggestion;Supportive care;Surgical Oncology;survivorship;symptom management;System;Universities

PROJECT_TITLE: Protocol Review and Monitoring System


NIH_SPENDING_CATS: Clinical Research

PI_NAMEs: SCARINCI, ISABEL C (contact)

PROJECT_TERMS: Achievement;Alabama;cohort;Collaborations;Common Data Element;Communication;Communities;community building;community collaboration;Data;Data Collection;Development;diversity and inclusion;Effectiveness;equity, diversity, and inclusion;Evaluation;expectation;experience;Extramural Activities;Faculty;Fostering;Funding;Goals;Grant;improved;Institution;Investigation;Logic;Methods;Modeling;Nature;organizational climate;Outcome;Output;Policies;Process;process evaluation;Productivity;Program Sustainability;programs;Publications;Recording of previous events;recruit;Research;Research Support;Resources;Responsible Person;Sample Size;Scientist;synergism;Testing;timeline;tool;Translating;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: UAB/TU FIRST Evaluation Core


PI_NAMEs: HOLLINGSWORTH, MICHAEL A. (contact)

PROJECT_TERMS: Basic Science;Bioinformatics;Biometry;Cancer Center;Cancer Center Support Grant;Communication;cost effectiveness;Ensure;Equipment;Feedback;Flow Cytometry;functional status;Funding;Funding Agency;Future;Goals;Grant;Human Resources;improved;Institution;Leadership;Malignant Neoplasms;meetings;member;Microscopy;Molecular Biology;Monitor;operation;Pathology;Policies;preclinical imaging;Process;Productivity;programs;Publications;Quality Control;Reporting;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;satisfaction;Services;structural biology;Suggestion;Surveys;Technology

PROJECT_TITLE: Shared Resource Management


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PI_NAMEs: BASSNETT, STEVEN  (contact)

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Neurosciences

PROJECT_TERMS: Animals;Core Grant;Cryoultramicrotomy;detector;Electron Microscopy;Equipment;experience;Faculty;Fluorescence;Future;Histologic;Image;immunocytochemistry;In Situ Hybridization;Individual;instrument;instrumentation;Laboratories;Lasers;light microscopy;live cell imaging;member;Microdissection;Microscope;multi-photon;multiphoton microscopy;ocular imaging;Optical Coherence Tomography;Paraffin;Plastic Embedding;Productivity;Research Personnel;Resources;Schedule;Scientist;Services;Source;Stains;System;Talents;Tissues;Training;Universities;Vision;Vision research;Visual System;Washington

PROJECT_TITLE: Imaging Core


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Comparative Effectiveness Research;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Opioids;Pain Research;Patient Safety;Social Determinants of Health;Suicide

ORG_CITY: NEW YORK

ORG_DEPT: EMERGENCY MEDICINE

PHR: PROJECT NARRATIVE Since release of the 2016 CDC Guideline for Prescribing Opioids for Chronic Pain, over 200,000 Veterans Health Administration (VHA) patients have had their long-term opioid therapy (LTOT) discontinued despite unclear long-term health risks and limited knowledge about the barriers to, and clinical effectiveness of the therapies used to supplement LTOT taper, such as non-pharmacological modalities (NPM). This project will leverage VHA electronic health record data to provide needed information to healthcare providers, healthcare administrators, and policy makers on the health consequences of LTOT taper or discontinuation among adults living with chronic pain, barriers to receipt of NPM for veterans who taper or discontinue LTOT, and whether use of NPM affects clinical outcomes on a large scale, which is crucial information for establishing safe and effective strategies for tapering prescription opioids.

PI_NAMEs: MANNES, ZACHARY L (contact)

PROGRAM_OFFICER_NAME: BAUMGARTNER, JENNIFER NICOLE

PROJECT_TERMS: Address;Administrator;Adult;adverse outcome;Affect;Analgesics;Area;Authorization documentation;Behavior Therapy;Biometry;career;career development;Caring;causal model;Characteristics;chiropracty;chronic pain;chronic pain management;chronic pain patient;Clinical;clinical care;Clinical effectiveness;clinical epidemiology;Combined Modality Therapy;comorbidity;cost;Cox Proportional Hazards Models;Cross-Sectional Studies;Data;Data Sources;design;Development;Development Plans;Diagnostic;Documentation;Educational workshop;effective therapy;Electronic Health Record;Emergency department visit;Epidemiology;epidemiology study;follow-up;Geographic Factor;Geography;Goals;Guidelines;Health;Health care facility;health disparity;Health Personnel;health service use;Health Services;Health Services Research;Healthcare;Healthcare Systems;Hospitalization;Improve Access;improved;Information Systems;Insurance Carriers;Integrated Health Care Systems;Intervention;Knowledge;Linear Models;Longitudinal cohort;Medicaid;Medical;Mentors;Mentorship;Modality;Modeling;Morbidity - disease rate;mortality;multimodality;National Center for Complementary and Integrative Health;non-opioid analgesic;Observational Study;Opioid;opioid epidemic;opioid overdose;opioid tapering;opioid therapy;opioid use;Outcome;Overdose;overdose death;Pain;Pain intensity;Pain management;Patient-Focused Outcomes;Patients;Persons;Pharmacy facility;Physical Rehabilitation;Policies;Policy Maker;prescription opioid;Proportional Hazards Models;Protocols documentation;psychologic;Public Health;Quality of life;Recommendation;Recording of previous events;Research;Research Design;Research Methodology;response;Retrospective cohort;Risk;risk mitigation;Scientist;Services;skills;sociodemographics;standard care;substance use;Suicide;suicide mortality;symposium;Time;Training;Training Programs;Treatment Effectiveness;United States;Update;uptake;Use Effectiveness;Veterans;Veterans Health Administration;Vulnerable Populations

PROJECT_TITLE: Barriers to and Health Consequences of Non- Pharmacological Chronic Pain Treatment among Patients Tapering Prescription Opioids in a Large Integrated Healthcare System


NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Eye Disease and Disorders of Vision;Genetics

PI_NAMEs: CHEN, SHIMING  (contact)

PROJECT_TERMS: Collaborations;Core Grant;Cryopreservation;Derivation procedure;design;DNA Library;Electroporation;embryo cryopreservation;Fertilization in Vitro;Gene Modified;Gene Targeting;Genotype;Knockout Mice;Maintenance;Microinjections;Molecular Genetics;Mouse Strains;multidisciplinary;Mus;pathogen;Procedures;Production;Recombinant DNA;Research;Research Personnel;Resources;Scientist;Services;sperm cell;Technology;Transgenic Organisms;Universities;Viral Vector;Vision;Vision research;Washington

PROJECT_TITLE: Molecular Genetics Core


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences

PI_NAMEs: GORDON, MAE O (contact)

PROJECT_TERMS: Archives;Area;Bioinformatics;bioinformatics resource;Biometry;Biostatistics Core;ChIP-seq;Collection;Computational Biology;Core Grant;Data;data sharing;deep sequencing;Ensure;expectation;experimental analysis;Experimental Designs;Faculty;falls;large datasets;Proteomics;Publications;Research;Research Personnel;response;Scientist;Security;single-cell RNA sequencing;Somatic Mutation;Statistical Data Interpretation;Technology;tool;Universities;Vision;Vision research;Washington

PROJECT_TITLE: Biostatistics and Bioinformatics core


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurosciences

PI_NAMEs: KEFALOV, VLADIMIR JIVKOV (contact)

PROJECT_TITLE: Visual Function Testing Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: VERMILLION

ORG_NAME: UNIVERSITY OF SOUTH DAKOTA

PI_NAMEs: HUBER, VICTOR CHESTER (contact)

PROJECT_TERMS: Address;Annual Reports;Area;Award;Bioinformatics;Biomedical Research;Black race;career;Cells;Cellular biology;Core Facility;Development;Education;Educational process of instructing;Enrollment;Faculty;faculty mentor;Funding;Future;Genetic;Genomics;Goals;Growth;Human Resources;Institution;Institutionalization;interest;Lead;Measurable;medical schools;member;microbial;National Institute of General Medical Sciences;Network Infrastructure;outreach;Phase;Privatization;programs;Proteomics;Research;research faculty;Research Infrastructure;Research Personnel;Research Support;Resources;Science;science education;South Dakota;student participation;Students;tribal college;undergraduate student;United States National Institutes of Health;Universities


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Pediatric

PI_NAMEs: GNIMPIEBA Z., ETIENNE  (contact)

PROJECT_TERMS: 3D Print;Academia;Acceleration;Achievement;Address;Automobile Driving;Basic Science;Bioinformatics;Biological;Biological Sciences;Biomedical Engineering;Biomedical Research;Cells;Child;children's museum;Collaborations;college;Communication;Communities;Community Outreach;computer framework;computerized data processing;course development;cyber infrastructure;Data;data management;Data Science;Data Set;Development;Discipline;DNA;Education;education resources;Educational workshop;experience;Faculty;Family member;Funding;Funding Agency;Future;Future Generations;General Population;Genetic;Genome;Genomics;Goals;High School Faculty;high throughput technology;Image;in silico;Individual;Industry;Infrastructure;Institution;inter-institutional;Interdisciplinary Study;interest;junior high school;K-12 Education;Knowledge;large datasets;Libraries;member;Mentors;metabolome;Middle School Faculty;Middle School Student;Mission;model building;Modernization;Nebraska;Network Infrastructure;next generation sequencing;Occupations;outreach;outreach program;Phase;phenomics;programs;Proteome;Research;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Science;Scientist;Secure;South Dakota;STEM career;Strawberries;Students;Technology;tool;Training;transcriptome;Translating;United States National Institutes of Health;Universities;virtual;vision development;Youth

PROJECT_TITLE: Bioinformatics


ORG_CITY: OMAHA

PI_NAMEs: CAPLAN, STEVEN H (contact)

PROJECT_TERMS: Cancer Center;Cancer Center Support Grant;cell fixing;Cells;Communities;Consultations;Core Facility;Coupled;Data;Dedications;design;Development;experimental study;Fees;Goals;Image;Image Analysis;image processing;Imaging Techniques;innovation;Laser Scanning Confocal Microscopy;light microscopy;Lighting;live cell imaging;Maintenance;Medical center;member;Microscope;Microscopic;microscopic imaging;Microscopy;Modeling;molecular imaging;Nebraska;notch protein;Optics;Photobleaching;Publishing;reconstruction;Research;Research Personnel;Resolution;Resource Sharing;Services;single molecule;Structure;superresolution microscopy;Techniques;Technology;Three-Dimensional Imaging;Tissues;Training;ultra high resolution;Universities

PROJECT_TITLE: Advanced Microscopy Shared Resource


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding

PI_NAMEs: CALLEGARI, EDUARDO A. (contact)

PROJECT_TERMS: Address;Area;Award;Bioinformatics;Biomedical Research;Black race;career;cell growth;Cellular biology;Collaborations;Core Facility;Databases;design;Development;Education;Faculty;faculty mentor;Funding;Future;Genetic;Genomics;Genotype;Goals;graduate student;Housing;Human Resources;improved;Infrastructure;insight;Institution;interest;Libraries;medical schools;National Institute of General Medical Sciences;Network Infrastructure;Nucleic acid sequencing;Pattern;Phase;Postdoctoral Fellow;programs;protein expression;Proteomics;Protocols documentation;Recording of previous events;Research;Research Personnel;Research Support;Science;science education;South Dakota;Students;support network;System;Training;tribal college;undergraduate student;United States National Institutes of Health;Universities;Vision

PROJECT_TITLE: Proteomics


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome

PI_NAMEs: ANDERSON, CYNTHIA  (contact)

PROJECT_TERMS: Address;Appropriateness Review;Biomedical Research;Communities;Consultations;Core Facility;Data;Data Analyses;DNA sequencing;DNA Sequencing Facility;Ensure;experience;Faculty;Genetic;Genomics;Genotype;Goals;graduate student;Grant;improved;Infrastructure;Institution;instrumentation;interest;Maintenance;Massive Parallel Sequencing;Network Infrastructure;next generation sequencing;Nucleic acid sequencing;outreach;Performance;Procedures;quality assurance;Research;Research Personnel;Research Project Grants;Research Support;Research Training;response;Schools;Secure;sequencing platform;Services;South Dakota;STEM career;student training;Students;Techniques;Technology;Training;undergraduate student

PROJECT_TITLE: Nucleic Acids Sequencing Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: GUDA, CHITTIBABU  (contact)

PROJECT_TERMS: Adopted;Affect;anti-cancer research;Area;Award;Big Data;Bioinformatics;bioinformatics resource;Bioinformatics Shared Resource;bioinformatics tool;Biological;Biological Process;Cancer Biology;Cancer Center;Cancer Center Support Grant;cancer genomics;Cancer Research Project;cell free DNA;ChIP-seq;CLC Gene;Cloud Computing;cluster computing;Collaborations;Collection;college;Communities;comparative genomic hybridization;computer infrastructure;computer program;computer science;Computer software;Consultations;Custom;Data;Data Analyses;data analysis pipeline;data pipeline;Data Set;Data Storage and Retrieval;Databases;Dedications;deep learning;Development;Diagnostic;Discipline;DNA methylation profiling;DNA sequencing;drug discovery;Emerging Technologies;Environment;Epigenetic Process;exome sequencing;experimental analysis;Experimental Designs;experimental group;falls;Funding;Gene Expression;gene product;Genes;Genetic;genomic data;Genomics;Goals;Grant;high dimensionality;High Performance Computing;Homology Modeling;Human Resources;improved;Individual;Infrastructure;infrastructure development;Institution;Internet;Investments;Laboratory Research;Licensing;Machine Learning;Malignant Neoplasms;Maps;member;metabolomics;Metagenomics;Methods;Methylation;Micro Array Data;Molecular;Multiomic Data;Nature;Neoplasm Circulating Cells;neoplasm resource;next generation sequencing;novel;open source;open source tool;Output;Pathway Analysis;Pathway interactions;Performance;Policies;precision medicine;Procedures;prognostic;programs;Proteins;Proteomics;Protocols documentation;Public Domains;Quality Control;Recommendation;Research;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Running;Services;single cell genomics;single cell sequencing;software development;Software Tools;Source;statistics;student mentoring;supercomputer;Systems Biology;Technical Expertise;Technology;Testing;The Cancer Genome Atlas;tool;Training;Training Programs;Training Support;transcriptome sequencing;transcriptomics;Trust;United States National Institutes of Health;Visualization software;volcano;whole genome

PROJECT_TITLE: Bioinformatics Shared Resource


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Transgender and non-binary persons (TGNB) experience intimate partner violence (IPV) at alarming rates and prior work has linked IPV with sexual risk-taking behavior and to increased risk for HIV seroconversion among TGNB, but less is known about the impact of IPV on HIV/STI testing, pre-exposure prophylaxis (PrEP) uptake, and the persistence of PrEP use among subgroups of TGNB. The proposed innovative observational cohort study will examine how various forms of IPV (e.g., physical, sexual, emotional, TGNB-identity specific), in the context of steady or casual intimate relationships contribute to HIV/STI risk and protective behaviors among TGNB persons over a 24-month timeframe. This research will advance our understanding of both the risk and resilience factors relevant to preventing and reducing IPV, reducing HIV risk behaviors, and increasing HIV protective behaviors among diverse TGNB.

PI_NAMEs: STORHOLM, ERIK D. (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: Address;AIDS prevention;Alcohol consumption;assigned female at birth;assigned male at birth;Behavior;Characteristics;Child Abuse;cisgender;cohort;Communities;Coping Skills;Data;design;Development;Diagnosis;Emotional;Enrollment;ethnic diversity;Etiology;Exclusion;experience;Family;follow-up;Frequencies;Gender;gender affirmation;gender diverse;gender expression;Gender Role;gender transition;Goals;high risk;HIV;HIV risk;HIV Seronegativity;HIV Seropositivity;Human immunodeficiency virus test;inattention;Individual;Infection prevention;infection risk;innovation;Interruption;Intervention;intimate partner violence;Knowledge;Life Experience;Link;Longitudinal cohort;male;Measures;Mediating;Mental Health;Methodology;Methods;minority stress;Modeling;nonbinary;observational cohort study;Outcome;Participant;Pathway interactions;peer;Persons;Population;pre-exposure prophylaxis;prevent;prevention service;primary outcome;prospective;protective behavior;psychologic;Psychosocial Factor;racial diversity;Recommendation;Recording of previous events;recruit;Reporting;Research;Research Activity;Research Priority;resilience factor;Risk;Risk Assessment;Risk Behaviors;Risk Factors;secondary outcome;Services;Severities;Sex Behavior;sexual minority men;sexual risk behavior;sexual risk taking;Sexually Transmitted Diseases;Shapes;social;Social support;structural determinants;Subgroup;Substance abuse problem;substance use;syndemic;Testing;theories;Time;transfeminine;transgender;transmasculine;Unsafe Sex;uptake;Victimization;Violence;violence prevention;Work

PROJECT_TITLE: Intimate Partner Violence and HIV Prevention Continuum Engagement Among Transgender and Nonbinary Populations

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


PROJECT_TERMS: Address;Award;Biomedical Research;design;Development;Educational process of instructing;Environment;Faculty;Funding;Goals;Institution;Network Infrastructure;Program Research Project Grants;programs;Research;research and development;Research Personnel;Science;South Dakota;Teacher Professional Development;Time;tribal college;undergraduate student;United States National Institutes of Health

PROJECT_TITLE: Developmental Research Project Program


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Rural Health;Social Determinants of Health

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PI_NAMEs: ISLAM, NADIA S (contact)

PROJECT_TERMS: Agreement;American;Award;Budgets;Charge;Communication;Communities;community engaged research;community engagement;community partners;Compensation;Consultations;Contracts;Development;Diabetes Mellitus;Ensure;Equity;Ethnic Origin;Evaluation;Expenditure;experience;Funding;gender minority;Geographic Locations;Geography;Goals;Grant;Health education;Healthcare;Immigrant;Individual;Infrastructure;Institution;interdisciplinary collaboration;Leadership;Low income;Maintenance;marginalization;meetings;member;Monitor;Multiple Partners;Municipalities;Muslim religion;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;organizational structure;outreach;Process;Professional Organizations;Progress Reports;racial diversity;Recording of previous events;Registered nurse;Regulation;Research;Research Personnel;Resource Allocation;rural area;service delivery;Service delivery model;Services;Sexual and Gender Minorities;Shapes;Site;Strategic Planning;Structure;synergism;Training;Triage;United States;United States National Institutes of Health;urban area;Work


NIH_SPENDING_CATS: Cancer;Patient Safety

PI_NAMEs: SMITH, LYNETTE M (contact)

PROJECT_TERMS: anti-cancer research;Area;Basic Science;biomarker development;Biometry;Biostatistics Shared Resource;Biotechnology;Cancer Center;Cancer Center Support Grant;cancer prevention;Characteristics;Clinical Cancer Center;clinical development;Clinical Research;Clinical Trials;Clinical Trials Data Monitoring Committees;Collaborations;complex data;Computer Hardware;Computer software;Continuing Education;Data;data acquisition;Data Analyses;Data Collection;data management;data quality;design;Development;Ensure;experience;Faculty;flexibility;Funding;Goals;high dimensionality;human subject;innovation;Joints;Laboratories;Manuscripts;meetings;member;Methodology;Mission;Modeling;Monitor;Monitoring Clinical Trials;patient safety;Patients;Peer Review;Persons;Population Research;Positioning Attribute;programs;protocol development;Protocols documentation;Publications;Randomized;Reporting;Research;Research Design;Research Personnel;Resources;Review Committee;Sample Size;Schedule;Specific qualifier value;Statistical Data Interpretation;Statistical Methods;Translational Research

PROJECT_TITLE: Biostatistics Shared Resource


NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Primary Immunodeficiencies;Racial and Ethnic Minority Health Research;Rare Diseases;Rural Health;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Over 400,000 people in the United States are living with hidradenitis suppurative (HS), which is a chronic inflammatory disease marked by painful, recurrent skin abscesses, cysts, draining sinus tracts, and disfiguring scarring that disproportionately affects racial and ethnic minority groups. To address our limited understanding of the underlying factors that lead to the development and severity of hidradenitis suppurativa, this research proposal will examine individual-level, interpersonal-level, and community-level factors that influence hidradenitis suppurativa epidemiology, outcomes, and care experiences in a racially and socioeconomically diverse study population. This will enable the development and evaluation of evidence-based targeted interventions to improve outcomes in populations disproportionately burdened by this devasting disease.

PI_NAMEs: CHANG, AILEEN YENTING (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Address;Adult;Affect;Age;Awareness;Biological;Biological Response Modifier Therapy;Biometry;Black race;California;career development;Caring;chronic inflammatory disease;chronic inflammatory skin;Cicatrix;Clinic;Clinical;Clinical Investigator;cohort;Collection;Communities;community-level factor;County;Cyst;Data;data de-identification;data repository;Data Set;Data Sources;Dermatologist;Dermatology;design;Development;Development Plans;Diagnosis;Disease;Disease Outcome;Disparity;diverse data;economic determinant;Economics;effective intervention;Environment;Epidemiologic Methods;Epidemiology;ethnic minority;ethnic minority population;Ethnic Origin;Evaluation;evidence base;experience;Family;FDA approved;Foundations;Funding;Future;Generations;Goals;Health;Health behavior;health data;Health Disparities Research;health disparity;Health Services Accessibility;Health system;Hidradenitis Suppurativa;Hispanic;Immune;improved;improved outcome;indexing;Individual;inhibitor therapy;innovation;Institution;Intervention;Knowledge;low socioeconomic status;Mediating;Medical;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;minority patient;Modeling;multidisciplinary;National Institute on Minority Health and Health Disparities;Neighborhoods;Observational Study;Outcome;Pain;Participant;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Population;Prevalence;Process;Provider;Public Health;Public Hospitals;Race;racial diversity;racial minority;racial minority population;Recurrence;Reporting;Research;research and development;Research Methodology;Research Proposals;Rural Community;Rural Population;Sampling;San Francisco;Severities;Severity of illness;sex;Shapes;Sinus;Site;skills;skin abscess;skin disorder;social culture;social health determinants;sociodemographics;socioeconomic disparity;Socioeconomic Status;socioeconomics;Spanish/English;Structure;study population;Surveys;Techniques;therapy development;Time;Training;tumor necrosis factor-alpha inhibitor;United States;United States National Institutes of Health;Universities;Urban Community;Work

PROJECT_TITLE: Multilevel factors influencing racial, ethnic, and socioeconomic disparities in hidradenitis suppurativa