ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Greater inhibitory precision would lead to reduced side effects in therapeutics and deeper biological insight. The proposed research is significant because it will contribute a set of transformative theranostic tools for study and modulation of RNA-governed biology through inhibition and reporting of critical RNA tertiary interactions. If successful, our approach would open new potential therapeutic and diagnostic avenues via probing and inhibition of RNA tertiary contacts.

PI_NAMEs: BONG, DENNIS  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TITLE: Synthetic strategies for non-canonical hybridization to structural motifs in RNA

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Data Science;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: CLEVELAND

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE The Case Western Reserve Alzheimer’s Disease Translational Data Science (ADTDS) Training Program cross- trains pre-doctoral students in data science and translational research techniques to become productive, independent scientists focused on Alzheimer’s Disease treatment therapeutic discovery. Our trainees are selected from a competitive pool of Ph.D. applicants, and develop research projects within a rich collection of National Institute on Aging funded programs with nationally and internationally recognized leaders in AD research.

PI_NAMEs: BUSH, WILLIAM S (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Alzheimer's Disease;Data Science;Training Programs

PROJECT_TITLE: The Alzheimer's Disease Translational Data Science Training Program


ADMINISTERING_IC: GM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Pediatric;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE STEM careers are rewarding and well remunerated, yet Latinas and African American women are significantly underrepresented. Seeds of Success provides middle-school girls from underrepresented backgrounds with relatable STEM role models who shape confident attitudes and guide formative STEM experiences that are reinforced through peer and community outreach. The long-term goal is to empower young girls to pursue future careers in STEM professions.

PI_NAMEs: GUERRERO-MEDINA, GIOVANNA  (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: African American Women;Attitude;Back;Biological Sciences;career;Career Exploration;Code;Collection;college;Communities;Community Outreach;community-centered;computer science;Control Groups;Critical Thinking;Development;digital;Disparity;Education;Educational workshop;empowerment;Engineering;Ethnic Origin;experience;Experimental Designs;Exposure to;Feedback;Female;follow-up;Friends;Future;Gender;girls;Goals;graduate school;Grant;high school;Hispanic Americans;improved;innovation;interest;Intervention;junior high school;Latina;Latina Population;Leadership;Learning;mathematical ability;Measures;meetings;member;Mentors;Motivation;ninth grade;optimism;Outcome;outreach;Participant;Pathway interactions;peer;Persons;Population;Preparation;Problem Solving;programs;Puerto Rico;Race;recruit;Remunerations;Reporting;Research;Rewards;role model;Schools;Science;Science, Technology, Engineering and Mathematics;Scientist;Self Efficacy;Series;Shapes;skills;social bias;Social Identification;Societies;STEM career;STEM field;Stereotyping;Structure;Students;success;Surveys;Talents;Technology;therapy design;Training;Underrepresented Populations;Underrepresented Students;underserved students;United States National Institutes of Health;Universities;Visit;volunteer;webinar;Woman;women of color

PROJECT_TITLE: Seeds of Success: Empowering Girls in STEM Through Mentoring, Access, and Leadership

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Biomedical Informatics and Data Science at Institute for Informatics (BIDS@I2) is a summer internship program aiming to provide opportunities for undergraduate and master students to explore the field of biomedical informatics and data science. BIDS@I2 will support the following areas: 1) an inclusive and supportive environment for all students, with special efforts to recruit students with limited resources and from underrepresented groups; 2) diverse research directions to accommodate students with various backgrounds and skills; 3) interdisciplinary collaboration across the spectrum of biomedical informatics and data science; 4) research projects with a long-term impact on the use of information to improve clinical practice, life science, and patient-centered outcomes; and 5) prepare students for graduate school as well as future careers in STEM research.

PI_NAMEs: ABRAHAM, JOANNA ;YEN, PO-YIN  (contact)

PROJECT_TERMS: Admission activity;African American population;Alaska Native;American Indians;Area;Award;Bioinformatics;Biological Sciences;biomedical data science;biomedical informatics;Biomedical Research;Biometry;broadening participation research;career;Career Choice;Characteristics;Clinical Informatics;clinical practice;Clinical Research;Collaborations;Communication;Competence;computer science;Data;Data Science;Data Science Core;Disabled Persons;Discipline;Discipline of Nursing;Education Projects;education research;Educational Curriculum;Engineering;Environment;equity, diversity, and inclusion;Ethnic Origin;Evaluation;experience;Exposure to;Faculty;faculty mentor;Feedback;Fostering;Funding;Future;Goals;Graduate Education;graduate school;graduate student;hands on research;Health Sciences;Healthcare;Hispanic Populations;Home;improved;Individual;Industrialization;Informatics;innovation;Institution;interdisciplinary collaboration;Knowledge;Learning;Mathematics;medical schools;Medicine;meetings;Mentors;Methods;minority trainee;Native Hawaiian;Native Hawaiian or Other Pacific Islander;outreach;Patient-Focused Outcomes;peer;Personal Attribute;Persons;Pharmacy facility;population health;Problem Solving;Professional Role;programs;prospective;Psychology;Public Health;Public Health Informatics;recruit;Research;Research Personnel;Research Project Grants;research to practice;Resources;role model;Schools;Science, Technology, Engineering and Mathematics;Secure;skills;Social Network;STEM research;Structure;student participation;Student recruitment;student training;Students;success;summer internship;supportive environment;theories;Training;Training Activity;Translating;Translational Research;undergraduate student;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;United States National Library of Medicine;Universities;Visual;Vocational Guidance;Washington;Woman;women faculty;Writing


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

ORG_CITY: Raleigh

ORG_NAME: ADAMAS NANOTECHNOLOGIES, INC.

ORG_STATE: NC

PHR: Imaging and MRI in particular play central roles in preclinical in vivo studies as key experimental tools to understand disease progression and develop therapeutic responses. While MRI is well developed and is fully suitable for deep tissue imaging where the optical imaging fails, the further improvements in sensitivity and resolution require conceptually new ideas for MRI contrast agents and associated methods. The purpose of this technology development project is to develop photo-hyperpolarizable nanodiamond-based 13C contrast agents and decoupling schemes to achieve a dramatic – at least six orders of magnitude – boosts in 13C NMR signal to enable high resolution deep tissue MRI including affordable low field MRI scanners.

PI_NAMEs: AJOY, ASHOK ;SHENDEROVA, OLGA A (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Address;Adoption;attenuation;Biodistribution;Biological;Biological Process;Biological Sciences;biomaterial compatibility;biomedical imaging;Cell Nucleus;Cells;cellular imaging;Clinical;clinical imaging;contrast imaging;Contrast Media;cost;Data;Defect;Development;Devices;Diamond;Disease;Disease Progression;Electronics;Endowment;Environment;Equilibrium;fluorescence imaging;Future;high resolution imaging;High temperature of physical object;Hour;Image;imager;imaging agent;Imaging Device;imaging modality;Imaging technology;immune imaging;improved;In Situ;in vivo;Infrastructure;innovation;Label;Length;Ligands;Light;light scattering;Lighting;Longitudinal Studies;magnetic field;Magnetic Resonance Imaging;meter;Methodology;Methods;microwave electromagnetic radiation;molecular marker;multidisciplinary;nanodiamond;nanoparticle;nanosized;Natural regeneration;new technology;Nitrogen;Noise;novel;Nuclear;optical imaging;Optics;particle;Particle Size;Play;portability;pre-clinical;preclinical imaging;preservation;prototype;Relaxation;Reproducibility;Research;Research Personnel;Resolution;Role;Scheme;Signal Transduction;Speed;Structure;Study models;submicron;Surface;Techniques;Technology;technology development;Temperature;temporal measurement;Tissue imaging;tissue phantom;Tissues;tool;treatment response

PROJECT_TITLE: Photo-hyperpolarized 13C MRI

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: ALBUQUERQUE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: NARRATIVE (AIM COBRE Overall) Autophagy is a novel, medically highly relevant process functioning in all healthy human cells, which together with the overlapping areas of inflammation and metabolism represents the thematic focus of the proposed Phase II center. Autophagy, inflammation and metabolism have broad medical relevance in cancer, obesity, diabetes, heart disease, Alzheimer’s disease, inflammatory bowel disease, aging, local and dangerous global emerging infections, autoimmune diseases, etc. The Phase II Autophagy, Inflammation and Metabolism (AIM) Center of Biomedical Research Excellence will achieve local impact by enhancing the research base in New Mexico and will represent a nationally important center for the advancement of research on autophagy, inflammation and metabolism in disease, presenting the state of New Mexico and the region with a cutting edge biomedical center of excellence, while giving the nation a resource for the development of new approaches in treating a wide spectrum of diseases.

PI_NAMEs: DERETIC, VOJO P (contact)

PROGRAM_OFFICER_NAME: NANDA, JAGPREET SINGH

PROJECT_TERMS: Address;Aging;aging population;Alzheimer's Disease;Area;Attention;Autoimmune Diseases;Automobile Driving;Autophagocytosis;base;Biomedical Research;Cardiovascular Diseases;Cells;Centers of Research Excellence;cohort;Communities;Dangerousness;Data Analyses;Data Collection;Dedications;Development;Diabetes Mellitus;Disease;Disparity;editorial;Emerging infection;Ensure;Environmental Risk Factor;Evaluation;experience;Faculty;Fostering;fundamental research;Funding;global health;Goals;Health;health disparity;Health Sciences;Heart Diseases;Human;Image;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Influentials;innovation;Institution;instrumentation;International;Malignant Neoplasms;Maps;Medical;member;Mentors;Metabolic;Metabolism;Nerve Degeneration;New Mexico;novel;novel strategies;Obesity;Output;Phase;Positioning Attribute;Process;programs;Publications;Publishing;recruit;Reproducibility;Research;Research Personnel;Resource Development;Resources;Scientific Advances and Accomplishments;Services;statistics;success;Sum;symposium;System;Techniques;Technology;Training;translational applications;translational impact;Translational Research;Universities

PROJECT_TITLE: Autophagy, Inflammation and Metabolism (AIM) in Disease Center - Phase 2.


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Advisory Committees;Aging;Area;Autoimmune Diseases;Autophagocytosis;base;cohort;Communities;Development;Development Plans;Diabetes Mellitus;Disease;Educational workshop;Effectiveness;Ensure;Equipment;equity, diversity, and inclusion;Evaluation;experience;Fees;Financial Activity;Fostering;Funding;Future;global health;Goals;Growth;Health;health disparity populations;Health Sciences;Human;Individual;Infection;Inflammation;Influentials;innovation;Institution;International;Joints;Lead;Leadership;Malignant Neoplasms;Mentors;Metabolism;National Institute of General Medical Sciences;Nerve Degeneration;New Mexico;next generation;obese person;Obesity;operation;Phase;Pilot Projects;Population;Positioning Attribute;Program Evaluation;programs;Publications;recruit;Reporting;Research;Research Personnel;Resources;Role;Series;skills;Source;Structure;success;synergism;Talents;Training;Universities;Vision

PROJECT_TITLE: Admin Core - Phase 2


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: MIAMI

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: RELEVANCE: This PPG application is focused on the critical role played by metabolic remodeling in the development of pulmonary vascular disease in children born with complex congenital heart defects that result in increased pulmonary blood flow (PBF). This PPG intensely focuses on understanding: i) the differential effects of flow vs pressure on cellular metabolic programming; ii) post translational modifications (PTMs) that influence key signaling pathways involved in metabolic reprogramming; iii) interactions between mitochondrial network dynamics, metabolism, and cellular survival; and iv) novel therapeutic strategies for treating CHD with increased PBF. Elucidating the contributions of these important cellular pathways to the development of pulmonary vascular disease could lead to improved survival of children born with congenital heart defects.

PI_NAMEs: BLACK, STEPHEN M (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: advanced disease;aerobic glycolysis;angiogenesis;Apoptosis;Apoptotic;Arteries;arteriole;Attenuated;Autophagocytosis;Bioenergetics;Biology;Blood flow;Blood Pressure;Blood Vessels;Cell division;Cell Proliferation;Cells;Cellular Metabolic Process;Child;Communication;comparison control;Complex;Complication;congenital heart abnormality;Congenital Heart Defects;Consumption;Development;Disease;disease model;Distal;endothelial dysfunction;Endothelium;Generations;Human;Hypertrophy;Impairment;improved;Individual;individualized medicine;insight;Investigation;lamb model;Link;Lung;lung vascular injury;mechanical force;Mechanical Stress;Medial;Mediating;Metabolic;Metabolism;Mitochondria;Modeling;Morphology;multicatalytic endopeptidase complex;Muscle;neonatal period;novel;novel therapeutic intervention;novel therapeutics;oxidation;Pathologic;Pathway interactions;Phenotype;Play;Post-Translational Protein Processing;postnatal;Pre-Clinical Model;pressure;programs;Pulmonary Circulation;pulmonary vascular disorder;Pulmonary vessels;Receptor Signaling;Respiration;response;Role;Shunt Device;Signal Pathway;Signal Transduction;Sphingosine-1-Phosphate Receptor;Stretching;Superoxides;synergism;therapeutic evaluation;translational scientist;Truncus Arteriosus;Ubiquitin;Vascular Diseases;Vascular remodeling;Vasodilation;Ventricular Septal Defects

PROJECT_TITLE: Metabolic Reprogramming and Pulmonary Vascular Disease in Congenital Heart Disease

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(JA)]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Lung;Pediatric;Pulmonary Hypertension;Rare Diseases

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP]


PI_NAMEs: CANNON, JUDY LIN (contact)

PROJECT_TITLE: Science Core


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Prevention;Rural Health

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE This proposal uses drinking water quality data for community water supplies (CWS) and regions that rely on private groundwater (1-mile grids) in California to describe spatiotemporal trends in annual levels of arsenic (wAs) and uranium (wU) between 1990-2020, as it relates to monitoring (subject vs. not subject to regulation) and changes to the US EPA maximum contaminant levels (occurring in the early 2000s). We then propose to investigate the association between long-term wAs exposure, and possible effect modification by co-exposure to wU, and two prevalent and etiologically relevant chronic diseases—cardiovascular disease and chronic kidney disease—in the California Teachers Study, a large prospective cohort of women living in California who have been followed for health outcomes for over 20 years. Our proposal seeks to provide critical information for future policy decisions by first describing the effectiveness of regulatory action in reducing levels of wAs and wU and identifying populations that remain exposed to high levels (e.g., private well users), and second addressing key gaps in knowledge about low-to-moderate wAs exposure, the unknown effects of wU co- exposure and the risk of cardiovascular and chronic kidney diseases.

PI_NAMEs: MEDGYESI, DANIELLE  (contact)

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: Acute myocardial infarction;Address;administrative database;Arsenic;California;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Cessation of life;Chronic Disease;Chronic Kidney Failure;Cohort Studies;Collaborations;Communities;comorbidity;Consumption;Data;Data Set;demographics;Diabetes Mellitus;dietary;Disease;Disease Outcome;drinking water;Effectiveness;End stage renal failure;endothelial dysfunction;Enrollment;Environmental Health;Environmental Risk Factor;Epidemiology;epidemiology study;Ethnic Origin;Etiology;Exposure to;Future;ground water;Hazard Assessment;Health;Hospitalization;Hypertension;Incidence;insight;Joints;Kidney;Knowledge;Life Style;lifestyle factors;Link;Malignant Neoplasms;Measurement;Modification;Monitor;mortality;Myocardial Infarction;nephrotoxicity;novel;Obesity;Outcome;Participant;Policies;Population;Population Sizes;Privatization;Property;prospective;Prospective cohort;Race;recruit;Regulation;renal damage;Reporting;Research Personnel;response;Retirement;Rice;Risk;rural area;Rural Population;Smoking;Socioeconomic Status;Soil;Source;Southeastern Asia;spatiotemporal;Stroke;System;systemic inflammatory response;teacher;Testing;Time;trend;Uranium;Water;Water Pollutants;water quality;Water Supply;Woman;Women's cohort

PROJECT_TITLE: Long-term exposure to arsenic, and the co-occurrence of uranium, in public and private drinking water: associations with cardiovascular and chronic kidney diseases in the California Teachers Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-L(20)L]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE At least half of the more than a quarter million newly diagnosed breast cancer patients do not make treatment decisions that are optimally aligned with their values and preferences, resulting in decisional regret and poorer treatment experiences and outcomes. We will develop a COMputerized PAtient-centered Collaborative Technology (COMPACT) to support personalized treatment decision making in breast cancer. Better personalization and involvement of patients in decision making can improve patient outcomes, reduce healthcare costs, and may improve health equity by supporting consideration of socioeconomic and other factors (e.g., values, goals) that influence treatment decisions.

PI_NAMEs: SALWEI, MEGAN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: CHANLONGBUTRA, AMORNRAT

PROJECT_TITLE: COMputerized PAtient-centered Collaborative Technology (COMPACT) to Support Personalized Decision Making in Breast Cancer

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


NIH_SPENDING_CATS: Asthma;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: Project Narrative Latino children experience disparities in asthma prevalence and outcomes and Island Puerto Rican children are particularly affected with the highest asthma morbidity. We propose to implement and evaluate the Puerto Rico-Asthma Integrated Response Program (PR-AIR) to address pediatric asthma disparities in San Juan, PR, an area of high asthma burden. PR-AIR integrates home and school-based evidence-based interventions and enhances communication across sectors of care, with an approach that will enable us to evaluate low and high-intensity implementation strategy packages tailored to the available family, school, and community resources.

PI_NAMEs: CHAVEZ, LIGIA M.;KOINIS MITCHELL, DAPHNE  (contact);MCQUAID, ELIZABETH L

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: Address;Adoption;Affect;Age;Algorithms;Area;Asthma;Behavior;Care given by nurses;Caregivers;Caring;Characteristics;Child;Childhood Asthma;Clinic;Collaborations;Communication;Communities;community collaboration;Consolidated Framework for Implementation Research;design;Development;Disease Management;Disparity;Effectiveness;effectiveness evaluation;effectiveness outcome;effectiveness/implementation design;Eligibility Determination;Enrollment;Ethnic Population;evidence base;Evidence based intervention;experience;Face;Family;family management;formative assessment;health care service utilization;Health Personnel;Healthcare;high risk;Home;Hybrids;implementation barriers;implementation strategy;improved;Individual;Insurance;Intervention;intervention program;Interview;Investments;Island;Knowledge;Latino;Maintenance;Maps;Methods;Modification;Morbidity - disease rate;Outcome;Pattern;Persons;Pharmaceutical Preparations;Phase;Physicians;preference;Prevalence;programs;Puerto Rican;Puerto Rico;Quality of life;Randomized;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;remote delivery;Research;Resources;response;Rhode Island;Risk;School Nursing;Schools;screening;Services;Severity of illness;Structure;success;System;technology platform;trial design;uptake;urban area;virtual;virtual intervention

PROJECT_TITLE: Puerto Rico Asthma Integrated Response Program (PR-AIR)

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: CA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetic Testing;Genetics;Human Genome;Prevention;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The proposed study aims to develop a simple and inexpensive blood test that can reliably detect and identify many types of cancers at early stages in order to improve patient outcomes and odds of survival.

PI_NAMEs: PISANIC II, THOMAS RUSSELL;WANG, TZA-HUEI JEFF  (contact)

PROGRAM_OFFICER_NAME: PATRIOTIS, CHRISTOS F

PROJECT_TERMS: Aberrant DNA Methylation;Algorithms;Alleles;Benchmarking;Biological Assay;Biological Markers;biomarker panel;bisulfite sequencing;Blood Tests;Cancer Detection;Cancer Diagnostics;Cancer Patient;cancer type;cell free DNA;Cells;Cessation of life;Clinical;clinical implementation;Code;cohort;Colon Carcinoma;Color;Complex;Control Locus;cost;cost effective;density;design;Detection;Development;Diagnostic;Diagnostic Procedure;digital;digital assessment;Discrimination;Disease;DNA;DNA Methylation;Dyes;early detection biomarkers;Early Diagnosis;Early identification;Endometrial Carcinoma;Fluorescence;Genetic Materials;Goals;Hematopoietic Neoplasms;imager;improved;Individual;Life;liquid biopsy;Logistic Regressions;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;melting;Methods;Methylation;methylation biomarker;methylation pattern;Microfluidic Microchips;Microfluidics;Modeling;Mutation;neoplastic cell;next generation sequencing;Non-Invasive Detection;novel;parallelization;Patient-Focused Outcomes;Patients;Performance;Persons;Plasma;rare cancer;ratiometric;Resolution;ROC Curve;Sampling;Scheme;Sensitivity and Specificity;Serum;single molecule;Site;Specificity;Technology;technology development;Time;Tissues;tool;tumor;tumor DNA;Tumor stage;Validation;Work

PROJECT_TITLE: A low-cost, multiplexed digital high resolution melt platform for DNA methylation-based detection and identification of cancers in liquid biopsies


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases;Prevention

PI_NAMEs: ROSAS LEMUS, MONICA  (contact)

PROJECT_TERMS: 2019-nCoV;5' Untranslated Regions;Address;Adenosylhomocysteinase;Anti-viral Agents;Autophagocytosis;Biochemical;Bioenergetics;Biological Assay;Cell Fractionation;Cells;Cellular biology;Cessation of life;Co-Immunoprecipitations;Complex;Computer software;Confocal Microscopy;coping;Coronavirus;COVID-19 pandemic;Detection;Development;Disease;drug resistance development;Enzymes;Epithelial Cells;Equilibrium;Genetic Transcription;Genus Hippocampus;global health;Glycolysis;Goals;Guanosine Triphosphate;Herd Immunity;Hybrids;Hydrolase;Hydrolysis;Immune system;Immunity;Immunofluorescence Immunologic;improved;Infection;Inflammation;Knowledge;Lung;Measures;Membrane;Metabolic;Metabolic Pathway;Metabolism;Methyltransferase;Mitochondria;new pandemic;new therapeutic target;novel therapeutics;Oxidative Phosphorylation;Oxygen Consumption;Phase;prevent;Process;Production;protein complex;protein purification;Rattus;Reaction;RNA;S-Adenosylhomocysteine;S-Adenosylmethionine;Stress;structural biology;Testing;therapeutic target;Time;Transferase;Translations;Vaccines;Variant;Vesicle;Viral;Viral Nonstructural Proteins;Viral Proteins;viral RNA;Virus;Virus Replication;zoonotic coronavirus

PROJECT_TITLE: Coronavirus capping and its impact on the host metabolism


ORG_CITY: PHOENIX

ORG_NAME: INTER TRIBAL COUNCIL OF ARIZONA, INC.

ORG_STATE: AZ

PHR: NARCH XI - American Indian Research Center for Health Overall Narrative The epidemiological profile of tribal communities in Arizona compares poorly with non-tribal communities in every category of health status indicators. American Indians, in general, experience a disproportionately high mortality rate. The average life expectancy for American Indians is 71.4 years old, while the US general populations’ life expectancy is 75.5 years old. American Indians have a 638% greater mortality rate due to alcoholism, a 400% greater mortality rate due to tuberculosis, a 291% greater mortality rate due to diabetes, and a 215% mortality rate due to accidents as compared to the U.S. general population. The ITCA American Indian Research for Health (AIRCH) was established in 2000 to reduce health disparities among American Indians and Alaska Natives by engaging tribes in research that is scientifically sound. ITCA works to improve the capacity of tribes in Arizona, including areas related to health. With over 60 staff and 30 projects, ITCA provides on- going technical assistance and over 100 annual trainings to Tribes in program planning and development, research and data collection, and resource development. The overall goal of the American Indian Research Center for Health is to support health research projects that benefit Tribal Members, develop relationships to enhance tribal governance and partnerships in health research, conduct research that honors Tribal sovereignty, and promote a cadre of AI/AN researchers in health disparities research. The University of Arizona and ITCA missions and activities differ in deliberate ways and the AIRCH unites our Tribally governed 501(c) 3 and our research intensive institution to provide a collaborative service to our 21 member Arizona Tribes, and the Arizona AIAN population. The institutions are fully committed to the continuing success and impact of AIRCH and are prepared to provide resources to aim of advancing the impact of health research benefiting Tribal constituents and to support Native students and faculty.

PI_NAMEs: DADGAR, MARIA  (contact);SOLOMON, TESHIA G. ARAMBULA

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: 4 year old;5 year old;Accidents;Address;Administrator;Alaska Native;Alcoholism;American Indians;Area;Arizona;big-data science;Biomedical Research;career;Categories;Communities;community research;Credentialing;cultural competence;Data;Data Collection;data sharing;Death Rate;Development;Diabetes Mellitus;Education;Enrollment;Ensure;Epidemiology;experience;Faculty;faculty research;Fellowship Program;General Population;Genomics;Goals;graduate student;Guidelines;Health;Health Disparities Research;health disparity;Health Status Indicators;improved;Individual;infection rate;Infrastructure;Institution;intertribal;Intervention;Knowledge;Life Expectancy;Medical center;member;Methods;Mission;Native American Research Center for Health;Pathway interactions;Patients;Population;Procedures;Process;programs;Public Health;Reduce health disparities;Relationship-Building;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resource Development;Resources;Risk;SARS-CoV-2 infection;Scientist;Services;skill acquisition;social;sound;Students;success;System;Talents;Technology;Testing;Time;Training;tribal community;Tribal Council;tribal health;tribal leader;tribal member;tribal Nation;Tribes;Trust;Tuberculosis;Universities;Work

PROJECT_TITLE: FY21 ITCA NARCH XI

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-Y(55)]


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Drug Abuse (NIDA only);Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research;Substance Misuse

PHR: Administrative Core – Narrative The Inter Tribal Council of Arizona, Inc. (ITCA), is a tribally controlled non-profit organization established in 1975. ITCA has the goal of promoting American Indian self-reliance through public policy development, and to provide Member Tribes with the means for action on matters that affect them collectively and individually. The Member Tribes of ITCA are 21 federally-recognized Tribes located in the State of Arizona. The highest elected official of each Member Tribe serves on the council. These leaders have a comprehensive view of the conditions and needs of the tribal communities they represent. ITCA provides an independent capacity to obtain, analyze, and disseminate information vital to tribal community self-development. To build upon the ethical approach of research among the tribal communities, and continue a long- standing relationship with The University of Arizona in creating a space for developing AI/AN science focused students, ITCA proposes to provide the infrastructure for the Native American Research Centers for Health projects as the Administrative Core ensuring all rules and regulations of the award are delivered, along with efficient communication providing accountability of NARCH oversight.

PI_NAMEs: LANE, TRAVIS  (contact)

PROJECT_TERMS: Accountability;Advocate;Affect;Agreement;American Indian community;American Indians;Antibiotic Resistance;Arizona;Award;Bacteria;career;catalyst;Communication;Communities;community research;Data Collection;Data Science;Development;Education;Elements;Endocrine disruption;Ensure;Environment;Environmental Health;Ethics;Evaluation;Future;Goals;graduate student;Guidelines;Health;health disparity;Health Sciences;Healthcare;human subject protection;improved;Indigenous;Individual;Infrastructure;Institution;intertribal;Knowledge;Link;Medical;Metals;Methods;Mission;Native American Research Center for Health;Nonprofit Organizations;Pilot Projects;Policy Developments;Process;programs;Public Health Informatics;Public Policy;Recording of previous events;Regulation;Relationship-Building;Research;Research Ethics;Research Project Grants;Resource Development;Resources;Role;Science;Self Determination;self reliance;Students;success;Technology;Training;tribal community;Tribal Council;tribal member;tribal Nation;Tribes;Universities;wastewater epidemiology

PROJECT_TITLE: ITCA Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-Y]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Narrative Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are two devastating and fatal neurodegenerative disorders that are clinically distinct but show an overlap in genetic factors and central nervous system (CNS) neuropathology in the form of cytoplasmic TDP-43 depositions, but the mechanistic basis of their shared and distinct circuitry remains unknown at the molecular level, preventing the identification of needed therapeutic targets. Here, we use single-cell high-resolution profiling of epigenomic and transcriptional alterations in post-mortem CNS samples from ALS and FTLD with motor neuron disease (FTLD/MND) patients to elucidate their underlying mechanism of action, shed light on their common and distinct circuitry, and identify genetic and cellular factors that drive TDP-43 neuropathology and corresponding neurotoxicity, using patient derived cells and in vivo model systems. This ambitious proposal has the potential to (a) provide mechanistic insights into the development of ALS and FTLD/MND, (b) identify genetic modifiers of TDP-43 pathobiology, and (c) reveal functional risk variants and target genes for therapeutic intervention using gene modifying therapies.

PI_NAMEs: BELZIL, VERONIQUE ;DONNELLY, CHRISTOPHER JAMES (contact);HEIMAN, MYRIAM ;KELLIS, MANOLIS

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Address;Affect;ALS patients;Amyotrophic Lateral Sclerosis;Astrocytes;Autopsy;Bayesian Method;Biological;Biological Models;Brain Pathology;C9ORF72;Candidate Disease Gene;Cell Differentiation process;Cell model;cell type;Cells;Central Nervous System;Characteristics;Clinical;clinical phenotype;Coculture Techniques;Computational Technique;CRISPR screen;Cytoplasm;Data;Data Set;Deceleration;Deposition;Development;Diagnosis;differential expression;Disease;Dissection;Distal;DNA;Dura Mater;Enhancers;epigenomic profiling;epigenomics;Exclusion;Exhibits;experimental study;familial amyotrophic lateral sclerosis;Family;Fibroblasts;Frequencies;Frontotemporal Lobar Degenerations;frontotemporal lobar dementia amyotrophic lateral sclerosis;Gene Expression Profile;Gene Expression Profiling;Gene Modified;Genes;Genetic;genetic information;genetic manipulation;genetic risk factor;Genetic Transcription;genome wide association study;genomic locus;Health;Human;in vivo;in vivo Model;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;insight;Lead;Link;Liquid substance;Maps;Mediating;Mediation;Molecular;Motor;Motor Cortex;Motor Neuron Disease;Motor Neurons;mouse model;Mutation;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;Neurons;neuropathology;neurotoxicity;new therapeutic target;novel;Nuclear;Nucleic Acid Regulatory Sequences;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Phase;Phase Transition;Phenotype;Physiological;Population;pre-clinical;predictive signature;Prefrontal Cortex;prevent;Protein Isoforms;protein TDP-43;Recording of previous events;Regulatory Element;Research;Resolution;Resources;risk variant;RNA Processing;RNA-Binding Proteins;Sampling;single cell ATAC-seq;Single Nucleotide Polymorphism;single-cell RNA sequencing;sporadic amyotrophic lateral sclerosis;Symptoms;Therapeutic;Therapeutic Intervention;therapeutic target;Thoracic spinal cord structure;Tissues;trait;Transcription Alteration;transcriptome;Validation;Variant

PROJECT_TITLE: Identification of TDP-43 modifiers through single-cell transcriptional and epigenomic dissection of ALS and FTLD-MND

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J(70)R]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Dissemination and Implementation Research;Health Services;Lung;Patient Safety;Pediatric

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

ORG_STATE: CA

PHR: Project Narrative In this study, quality improvement teams in six geographically dispersed community hospitals will work to improve on asthma and bronchiolitis quality measures included in the Pediatric Respiratory Illness Measurement System-Short Version (PRIMES-SV). If the PRIMES-SV quality measures are found to be responsive to implementation science-informed quality improvement strategies, this study has the potential to provide critical information needed to improve community hospital-based respiratory illness care and outcomes for children nationally.

PI_NAMEs: MANGIONE-SMITH, RITA  (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: Abbreviations;Accident and Emergency department;Acute;Adherence;Admission activity;Applications Grants;Assessment tool;Asthma;Attitude;Belief;Bronchiolitis;care costs;care outcomes;Caring;Characteristics;Child;Childhood;Communities;Community Hospitals;Consensus;Consolidated Framework for Implementation Research;cost;Data;Diagnosis;Evaluation Research;Funding;Future;Geography;Goals;Hospitalization;Hospitalized Child;Hospitals;implementation barriers;implementation science;implementation strategy;improved;Incentives;Individual;influenza virus vaccine;innovation;Inpatients;Intervention;Knowledge;Length of Stay;Link;Measurement;Measures;Medical Records;Medicine;Monitor;National Heart, Lung, and Blood Institute;Outcome;Patients;Pediatric Hospitals;Performance;Population;Practice Guidelines;Process;Prospective Studies;Provider;provider factors;Quality of Care;respiratory;Specific qualifier value;Structure;System;Thoracic Radiography;tool;Variant;Work

PROJECT_TITLE: Pediatric Respiratory Illness Measurement System (PRIMES) Implementation in Community Hospital Settings

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Data Science;Drug Abuse (NIDA only);Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse

PI_NAMEs: SOLOMON, TESHIA G. ARAMBULA (contact)

PROJECT_TERMS: Alaska Native;American Indian community;American Indians;Area;Arizona;Asian population;Attention;authority;Award;biomedical informatics;Black Populations;Cardiovascular Diseases;career;Caring;Cessation of life;Chronic Disease;Clinical;Collaborations;college;Communities;Community Health;community research;Computerized Medical Record;Critical Thinking;cultural competence;cyber infrastructure;Data;Data Analytics;data management;Data Science;data science resource;Data Set;Databases;Decision Making;Development;Development Plans;Diabetes Mellitus;Disease;Diverse Workforce;Drops;Education;Elements;Epidemiologist;Epidemiology;Ethnic Origin;experience;Faculty;Fellowship;Fellowship Program;Fostering;Funding;Future;General Population;Goals;graduate student;Health;health assessment;health data;Health Disparities Research;health disparity;health organization;Health Personnel;Health Policy;Health Priorities;Health Professional;Hispanic Populations;Homicide;improved;Indigenous;Individual;individualized medicine;Informatics;insight;Institute of Medicine (U.S.);interest;intertribal;Knowledge;Learning;Malignant Neoplasms;Medical;Medical Informatics;medical specialties;Mentors;Methods;minority health professional;Motor Vehicles;National Institute of General Medical Sciences;Native American Research Center for Health;Paper;Participant;Pattern;Patterns of Care;Pharmaceutical Preparations;Procedures;programs;Public Health;Public Health Informatics;Publishing;Qualifying;Race;Recommendation;recruit;Reduce health disparities;Research;Research Assistant;Research Personnel;Research Project Grants;Resources;response;Risk;Role;Scientist;skills;Sociology;Special Population;statistics;Students;Substance abuse problem;success;Suicide;summer internship;Technology;Training;tribal community;Tribal Council;tribal health;Tribes;undergraduate student;United States Public Health Service;Universities;Urban Community

PROJECT_TITLE: UA Student Development: Data Warriors Fellowship Program


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE Despite asthma's high prevalence and morbidity among adolescents, particularly ethnic minority youth, few interventions target this age group. This study will test the efficacy and cost-effectiveness of CAMP Air, a high school-based e-health intervention in urban adolescents with uncontrolled asthma and will examine factors associated with delivery of the intervention. This project has considerable public health relevance because (1) it leverages technology to reduce health disparities, (2) it is delivered in high schools, maximizing the potential for the intervention to be sustained, and (3) it will inform strategies for the widespread implementation of CAMP Air.

PI_NAMEs: BRUZZESE, JEAN-MARIE  (contact)

PROJECT_TERMS: Address;Administrator;Adolescence;Adolescent;Adopted;Adoption;Affect;African American;Aftercare;Age;age group;Air;Asthma;Black race;Caregivers;Characteristics;Child;Childhood;Chronic Disease;clinical efficacy;clinical implementation;Collection;comparison control;Consolidated Framework for Implementation Research;cost;Cost Analysis;cost effectiveness;Cost Effectiveness Analysis;cost per quality-adjusted life year;cost-effectiveness ratio;Data;Development;disparity reduction;Dissemination and Implementation;economic value;Education;Educational process of instructing;efficacy evaluation;efficacy testing;eHealth;Enrollment;ethnic minority;experience;follow-up;Future;Goals;graduate school;Growth;Health;Health behavior;health disparity populations;Health education;High Prevalence;high school;Hispanic;Hispanic Americans;implementation determinants;implementation research;implementation science;implementation study;incremental cost;incremental cost-effectiveness;Intervention;intervention cost;intervention delivery;intervention effect;Intervention Studies;Interview;Latino;Learning;Maintenance;markov model;Measures;Methodology;Methods;minority children;Modeling;Morbidity - disease rate;mortality;motivational enhancement therapy;online intervention;Online Systems;Outcome;Participant;Pattern;Pharmaceutical Preparations;Pilot Projects;pilot trial;Play;Population;post intervention;primary outcome;process evaluation;programs;Public Health;public health relevance;pulmonary function;Quality Control;Quality of life;Quality-Adjusted Life Years;Randomized;randomized trial;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Reduce health disparities;Research;Resources;Risk;Role;scale up;Schools;Science;secondary outcome;Self Care;Self Management;skills;social cognitive theory;Spirometry;Steroids;Students;success;Symptoms;Technology;Teenagers;Testing;Translation Process;urgent care;Visit;Youth

PROJECT_TITLE: The Efficacy of CAMP Air, a Web-based Asthma Intervention, Among Urban Adolescents with Uncontrolled Asthma

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(OA)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Immunotherapy;Neurosciences

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE We will create a map of all of the interactions between the human cell-surface proteins that control cell communication, and determine how those interactions affect gene expression and cell fate. This will lead to a greater understanding of human physiology and is also likely to identify new therapeutic targets. In particular, we hope to find interactions in the immune system that can be exploited for development of new immunotherapy drugs.

PI_NAMEs: GARCIA, KENAN CHRISTOPHER;THOMSON, MATTHEW W.;ZINN, KAI G (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Acceleration;Address;Affect;Affinity Chromatography;anti-tumor immune response;Avidity;Award;Binding;Biochemical;Biological Assay;Biological Process;Biomedical Research;cancer immunotherapy;Cell Communication;Cell Physiology;Cell surface;Cell Surface Proteins;Cells;Cellular Assay;Chimeric Proteins;Code;Color;Communities;Development;Disease;Enzyme-Linked Immunosorbent Assay;Evaluation;experimental study;Extracellular Domain;Funding;Gene Expression;Genes;Goals;High-Throughput DNA Sequencing;Human;Immune system;Immunotherapy;In Vitro;in vitro Assay;in vivo;innovation;insight;Institution;knock-down;Knowledge;Ligands;Maps;Mass Spectrum Analysis;Mediating;Methods;nanoparticle;neoplastic cell;nerve stem cell;Nervous System;neural;Neurons;new technology;new therapeutic target;novel therapeutics;organ growth;Orphan;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Physiology;Process;programmed cell death ligand 1;programmed cell death protein 1;Protein Secretion;Proteins;Research;Resources;screening;single cell analysis;single cell mRNA sequencing;T-Lymphocyte;Technology;Testing;Therapeutic;therapeutic target;Transmembrane Domain;yeast two hybrid system;Yeasts

PROJECT_TITLE: A Global Map of Interactions Among Human Cell Surface Proteins and Secreted Ligands


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Genetics;Human Genome;Mental Health

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

ORG_STATE: IL

PHR: Genomic disorders are underscored by multi-gene dosage increase or decrease that surpass a critical biological threshold and result in pathology; thus, copy number variants (CNVs) offer a unique opportunity to study dosage sensitivity and genetic interaction. Neurodevelopmental traits are particularly enriched for pathogenic CNVs and represent a major unmet need for mechanistic elucidation and therapeutic development. In this competing renewal, we will use our in vivo tools to tackle questions of triplosensitivity, epistasis, and drug repurposing in genomic disorders.

PI_NAMEs: DAVIS, ERICA ELLEN (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: 16p11.2;19p13.1;Acceleration;Affect;Animal Model;Area;Attention;Biological;Biological Assay;biological systems;Biology;burden of illness;candidate identification;Cartilage;cell type;Cells;Collaborations;combinatorial;Complex;Copy Number Polymorphism;craniofacial;craniofacial development;Data;Data Set;Disease;Disease susceptibility;Dissection;dosage;drug candidate;drug development;drug discovery;drug repurposing;efficacy testing;Equilibrium;Face;Funding;Gene Combinations;Gene Dosage;Gene Expression Profile;Genes;Genetic;genetic architecture;genetic corepressor;Genetic Epistasis;Genetic Transcription;genomic data;genomic locus;Genomics;Histone Deacetylase;Human;Human Pathology;in vivo;Individual;inhibitor;Knowledge;Learning;Maps;Measures;Methods;model organism;Modeling;Molecular;Mus;Mutation;Neuroanatomy;neurodevelopment;Neurodevelopmental Disorder;Neurons;novel;Pathogenicity;Pathology;Pathway Analysis;Pathway interactions;Pharmaceutical Preparations;Phenocopy;Phenotype;phenotypic data;Physiological;Probability;Property;Protocols documentation;Rattus;Repressor Proteins;Role;RORA gene;Safety;safety testing;Syndrome;Testing;Therapeutic;therapeutic candidate;therapeutic development;Therapeutic Intervention;tool;trait;Transcript;Transcription Repressor;Transcriptional Regulation;transcriptome;transcriptomics;Translating;Validation;Work;Zebrafish

PROJECT_TITLE: Functional Dissection of CNVs in Neurodevelopmental Traits

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Drug Abuse (NIDA only);Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Infectious Diseases;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse

PHR: PROJECT NARRATIVE Wastewater-based epidemiology (WBE) is particularly relevant for Tribal communities who wish to measure population health. Quantification of wastewater concentrations from centralized sewer systems, integrated with sewer flow rates and community population load, can be used to assess substance abuse, infectious disease, and other health indicators, such as diabetes. This mentored faculty enhancement project will develop the framework for conducting WBE in Tribal communities, assess the perceptions of WBE health surveillance among Tribal stakeholders, and determine the relevant health metrics that can be measured in Tribal wastewater.

PI_NAMEs: CONROY-BEN, OTAKUYE  (contact)

PROJECT_TERMS: Address;Administrator;Agreement;Area;Arizona;Award;Bacteria;Biological;career;Chemicals;Collection;college;Communicable Diseases;Communities;contaminated water;Coronavirus;COVID-19;Data;data dissemination;Development;Diabetes Mellitus;Engineering;Epidemiologic Monitoring;epidemiology study;Ethics;European;Excretory function;experience;Exposure to;Faculty;faculty mentor;Future;Goals;gut microbiome;Health;health assessment;Health Benefit;health disparity;Human;Human Resources;Immunization;improved;Indian reservation;indigenous community;Infrastructure;Institutional Review Boards;intertribal;Investments;Knowledge;Measures;member;Mentors;Mentorship;metropolitan;Native American Research Center for Health;novel;Perception;Pharmaceutical Preparations;pollutant;Population;population health;professor;Protocols documentation;Public Health;Qualitative Research;Recommendation;Research;Research Personnel;Resources;responsible research conduct;Rural;Sampling;skills;Substance abuse problem;Surveys;System;tool;Training;tribal community;Tribal group;tribal health;tribal leader;tribal member;Tribes;Universities;Virus;Waste Products;wastewater epidemiology;wasting;Water;Work

PROJECT_TITLE: ASU Faculty Enhancement: Wastewater-based epidemiology: relevant health metrics in Tribal communities.


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Drug Abuse (NIDA only);Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research;Substance Misuse

PI_NAMEs: CARROLL, STEPHANIE RUSSO (contact)

PROJECT_TERMS: Address;Alaska;Area;Arizona;Australia;biobank;Canada;care seeking;Code;Collection;Communication;Communities;community engagement;Conflict (Psychology);Data;data access;Data Science;data sharing;Data Storage and Retrieval;design;Development;Educational workshop;Equity;Ethics;Funding Opportunities;Future;Genomics;Goals;Guidelines;Hawaii;Health care facility;Health Professional;Indigenous;Individual;informant;Infrastructure;innovation;Institution;Intellectual Property;interest;International;intertribal;Interview;Knowledge;Leadership;Link;Manuscripts;meetings;Native American Research Center for Health;New Zealand;open data;Outcome;Output;Ownership;Perception;Persons;Policies;policy recommendation;Privacy;Process;programs;Recording of previous events;Regulation;Research;Research Ethics;Research Personnel;Research Project Grants;Research Proposals;Resources;Respondent;Rights;Role;Sampling;Scholarship;Specimen;Surveys;symposium;System;Training;tribal college;Tribal Council;tribal health;tribal leader;tribal Nation;tribal organization;Tribes;Universities

PROJECT_TITLE: UA Research Project: Developing policy recommendations: Indigenous leader and individuals' perspectives on research, governance, and data sharing in Arizona


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Chronic Pain;Mental Health;Neurosciences;Pain Research

ORG_CITY: RICHARDSON

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

ORG_STATE: TX

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE: Postoperative pain and delirium are factors that complicate recovery and impose a substantial healthcare financial burden (~$60B/year). The overarching goal of this project is to identify key molecular pathways that underlie diverse neuroinflammatory processes involved in pain and delirium, to help reveal treatable targets.

PI_NAMEs: BURTON, MICHAEL D (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Accounting;Adopted;Affinity Chromatography;Age;age group;Aging;Behavioral;Body Temperature;Body Weight decreased;Brain;cell type;Cells;Clinical;clinically relevant;Cognition;Cognitive;Cognitive deficits;comorbidity;cytokine;Delirium;Elderly;Experimental Models;experimental study;Female;Financial Hardship;Genomics;Goals;Healthcare;Home;Human;Immune;Immune system;Inflammation;Inflammatory;innovation;innovative technologies;insight;interest;Intuition;male;Mental Depression;Messenger RNA;Methods;Microglia;Molecular;monocyte;Movement;Neuroimmunomodulation;neuroinflammation;Neurons;Neurosciences;novel therapeutic intervention;Operative Surgical Procedures;Outcome;Pain;Pathway interactions;Patients;Peripheral;Phase;Postoperative Pain;Postoperative Period;postoperative recovery;pre-clinical;Process;programs;Protein Biosynthesis;public health relevance;Recovery;Regulation;Research;Research Personnel;Resolution;Ribosomes;RNA;Rodent;sex;Stimulus;System;Techniques;therapeutic development;transcriptome;transcriptomics;Transgenic Mice;Translating;translational study;Variant;Vision;Work

PROJECT_TITLE: Mechanisms involved in postoperative recovery: a focus on pain, delirium, and neuroinflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-L(55)R]


NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: ALLEN INSTITUTE

ORG_STATE: WA

PHR: Project Narrative Upcoming brain-wide descriptions of synaptic connectivity are poised to transform our understanding of brain circuitry in the same way single-cell genomics has revolutionized our understanding of cell type diversity. It is critical to develop tools that link genetically defined cell types to brain-wide circuit diagrams to understand brain function. We propose linking genetic and circuit data sets by scaling and sharing technologies that measure features common to both datasets across the entire mouse brain at the single cell level.

PI_NAMEs: JARSKY, TIM M;SORENSEN, STACI A (contact);SUMBUL, UYGAR

PROGRAM_OFFICER_NAME: JOHNSON, KARI ANNE

PROJECT_TERMS: Acceleration;Address;Adopted;Anatomy;Area;Automation;Axon;Basal Ganglia;Binding;Brain;brain circuitry;brain morphology;cell type;Cells;Collaborations;computer framework;Computer software;computerized data processing;Computing Methodologies;connectome;Data;Data Analyses;Data Set;data standards;Dendrites;Detection;Development;Electron Microscopy;Electrophysiology (science);experience;experimental study;flexibility;Gene Expression Profile;Generations;Genetic;Human;Image;Imaging technology;improved;Individual;Infrastructure;Interneurons;Link;Location;Machine Learning;machine learning method;machine vision;Measures;Methods;Modality;Modeling;Modernization;Molecular;Morphology;multimodal data;multimodality;multiple datasets;Mus;Neurons;novel strategies;open source;parallelization;patch clamp;patch sequencing;Positioning Attribute;Presynaptic Terminals;prevent;Property;reconstruction;Sampling;scale up;Science;single cell genomics;Synapses;synaptic function;Techniques;Technology;Testing;Tissue imaging;tissue processing;tool;Training;transcriptome;transcriptomics;Vesicle;Work

PROJECT_TITLE: BRAIN CONNECTS: PatchLink, scalable tools for integrating connectomes, projectomes, and transcriptomes


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Drug Abuse (NIDA only);Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research;Rural Health;Substance Misuse

PHR: NARCH XI: AIRCH Developing the Arizona Tribal Research Review Board Capacity Building  Project Narrative The cultural differences of conducting research within the American Indian/Alaska Native communities is becoming a greater concern of ethical and moral approach. A large number of researchers from institutions is vastly increasing with greater interest. However, an ethical approach to research conducted on tribal land is important from implementing a project, collecting the data and data sharing. The American Indian people are culturally connected to with an Indigenous framework of one’s self as a whole especially during research. The historical cases of mistrust of research from non-community members has promoted negative publications and promote stereotypes of AI/AN. The Belmont Report created in 1974 prompted the Indian Health Service to establish Institutional Review Board or other forms of research committees. Several Tribes have created IRBs; smaller tribes do not have the resources nor opportunity. As each tribal government is organized differently, the Inter Tribal Council of Arizona, Inc., goal is to serve as the Institutional Review Board for Member Tribes ensuring the research purpose is appropriate for the protecting and benefit for the tribal members and tribal communities. ITCA has developed a strong relationship with Member Tribes in addition to creating partnerships with research institutions.

PROJECT_TERMS: Address;Agreement;Alaska Native;Alaska Native population;American Indian Population;American Indian Tribe;American Indians;Arizona;authority;Awareness;Belmont Report;Biomedical Research;case history;Code;Collaborations;Committee Members;Communication;Communities;community building;Consultations;cultural competence;Data;Data Set;data sharing;digital data;distrust;Educational workshop;Ensure;Ethics;Fostering;Genetic;Goals;Health;Health Promotion;health record;human subject;improved;Indigenous;Individual;Infrastructure;Institution;Institutional Review Boards;Institutionalization;interest;intertribal;lightspeed;Link;member;Morals;Native American Research Center for Health;Notification;Online Systems;pilot test;Policies;Population;prevent;privacy protection;Procedures;Process;Protocols documentation;Publications;Recording of previous events;recruit;Reduce health disparities;Regulation;Research;Research Ethics;research faculty;Research Personnel;Research Project Grants;Research Support;Resolution;Resources;Rights;Science;Stereotyping;System;tool;Training;tribal community;Tribal Council;tribal institution;tribal lands;tribal leader;tribal member;tribal Nation;Tribally Based Participatory Research;Tribes;unethical;United States Indian Health Service;Universities;welfare

PROJECT_TITLE: ITCA Capacity Building: Developing the Arizona Tribal Research Review


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Skin Cancer;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Narrative Hispanics are diagnosed with melanoma at later stages than their non-Hispanic white (NHW) counterparts, leading to increased likelihood of metastasis and worse survival. We will investigate a number of modifiable factors likely to be related to diagnosis at later stage in Hispanics compared to NHW. The study will be carried out in Los Angeles County which has the required population-based cancer registry, high rates of melanoma among Hispanics, and factors likely to be related to delayed diagnosis that represent those seen throughout the U.S.

PI_NAMEs: COCKBURN, MYLES G (contact);MILLER, KIMBERLY ANN

PROGRAM_OFFICER_NAME: KOBRIN, SARAH

PROJECT_TERMS: Accounting;Acculturation;Acral Lentiginous Malignant Melanoma;Adherence;Awareness;cancer prevention;Clinic;Complex;County;cultural competence;cultural values;Data;Data Sources;design;Diagnosis;Disease;Disparity;Early Diagnosis;effective intervention;Ensure;Ethnic Origin;Ethnic Population;Etiology;experience;follow-up;health care availability;Health education;Health Services Accessibility;Hispanic;Hispanic Populations;Histologic;Histology;improved;Incidence;Intervention;Knowledge;Lesion;Los Angeles;Low income;Melanoma;Melanoma patient;mortality risk;multiple data sources;Neoplasm Metastasis;neoplasm registry;Not Hispanic or Latino;Outcome;patient-clinician communication;patient-level barriers;Patients;Pattern;Perception;Phase;Physicians;Population;population based;Predisposition;Primary Care;primary care setting;Prognosis;Reporting;response;Risk;Role;Rural Population;screening;screening guidelines;Self Efficacy;skin lesion;Stage at Diagnosis;Stress;System;Telemedicine;Testing;therapy design;Time;treatment response;tumor;United States

PROJECT_TITLE: Identifying modifiable factors that reduce the burden of late stage melanoma in Hispanics

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Nanotechnology;Precision Medicine;Prevention;Women's Health Research

ORG_CITY: GAINESVILLE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE The lack of reliable non-invasive blood biomarkers presents a serious obstacle to the personalized management and treatment of cancer, more importantly, metastatic and recurrent disease. Our proposal aims to develop new tools to investigate circulating exosomes as a new paradigm of liquid biopsy in solid tumors. New non-invasive exosomal biomarkers and tests could profoundly impact the clinical strategies to monitor disease status and treatment and in post-therapy follow-up, to detect early disease recurrence.

PI_NAMEs: XU, LIANG ;ZENG, YONG  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: 3-Dimensional;Acceleration;accurate diagnosis;Address;Advanced Development;Biological Markers;Biological Process;biomarker panel;Biosensing Techniques;Biosensor;Blinded;Blood;Breast Cancer cell line;Breast Cancer Patient;cancer diagnosis;Cell Communication;Cell Line;Cells;Characteristics;chemotherapy;Classification;Clinical;clinical diagnosis;clinical implementation;Clinical Research;Clinical Treatment;cohort;Development;Devices;Diagnosis;Diagnostic;Dimensions;Disease;disease diagnosis;disease model;Disease stratification;drug relapse;Drug resistance;drug testing;early detection biomarkers;Early Diagnosis;Engineering;Epithelium;Evolution;exosome;experimental study;Extracellular Matrix;extracellular vesicles;Face;follow-up;Genetic Complementation Test;Goals;Human;improved;In Vitro;in vivo;innovation;liquid biopsy;lithography;machine learning algorithm;Malignant Breast Neoplasm;Malignant Neoplasms;Matrix Metalloproteinases;Measures;Mediating;Mediator;Membrane;Mesenchymal;Metastatic/Recurrent;Methods;Microfluidic Microchips;microfluidic technology;Microfluidics;MMP14 gene;Modality;Molecular;Monitor;mouse model;Mus;Nanochip Analytical Device;nanoengineering;nanopattern;nanovesicle;Neoplasm Metastasis;new technology;next generation;novel;optimal treatments;patient derived xenograft model;patient stratification;Patients;Performance;personalized cancer therapy;personalized management;Phenotype;Pilot Projects;Plasma;precision medicine;precision oncology;Process;Prognosis;prognostic;Property;Protein Analysis;protein expression;Proteins;prototype;Recurrent disease;Relapse;Reporting;Research;response;Sampling;self assembly;Signal Transduction;Solid Neoplasm;Specimen;Staging;System;Technology;technology validation;Testing;Therapeutic;tool;Training;Translating;treatment response;treatment strategy;tumor;Tumor Burden;Tumor Cell Invasion;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-Derived;Validation;validation studies;Vesicle

PROJECT_TITLE: Integrative Functional Profiling of Tumor-Derived Extracellular Vesicles


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Pediatric;Prevention;Serious Mental Illness;Suicide;Suicide Prevention;Violence Research;Youth Violence

ORG_CITY: BRIGHTON

ORG_NAME: FRANCISCAN HOSPITAL FOR CHILDREN, INC.

ORG_STATE: MA

PHR: Public Health Relevance Statement Suicide is the 2nd leading cause of death among adolescents, with the highest risk period for suicide being the month following psychiatric inpatient hospitalization. We propose testing a brief, scalable intervention using evaluative conditioning aimed at reducing suicidal thoughts and behaviors among adolescents during and after inpatient hospitalization. Scalable interventions, such as the one proposed that reduce suicide risk during this markedly high-risk period, could result in large-scale decreases in suicide death.

PI_NAMEs: NOCK, MATTHEW K (contact)

PROGRAM_OFFICER_NAME: BURSTEIN, MARCY ELLEN

PROJECT_TERMS: 3-Dimensional;acceptability and feasibility;Address;Adherence;Adolescent;adolescent suicide;Adult;Association Learning;Attitude;Aversive Stimulus;Behavior;Belief;Cause of Death;Cellular Phone;Child;Clinical;Cognition;conditioning;effective intervention;Effectiveness;efficacy testing;Eligibility Determination;Ensure;experience;Feedback;Feeling suicidal;First Name;Forms Controls;Future;Goals;high risk;Hospitalization;Hospitals;Image;Inpatients;Intervention;Massachusetts;Mental Health Services;Methods;mobile application;non-suicidal self injury;novel strategies;operation;Outcome;Outpatients;paired stimuli;Patient Monitoring;Patients;Persons;Pilot Projects;Placebos;post intervention;prevent;Procedures;programs;Protocols documentation;psychiatric inpatient;Public Health;public health relevance;Punishment;Randomized;Randomized, Controlled Trials;reducing suicide;Research;Resources;Risk;rural area;Self-Injurious Behavior;skills;Skin;Snakes;Stimulus;suicidal;suicidal adolescent;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;suicide rate;Testing;Therapeutic;therapeutic evaluation;Thinking;Time;Treatment Efficacy;treatment response

PROJECT_TITLE: Therapeutic evaluative conditioning to reduce adolescents' self-injurious thoughts and behaviors during and after psychiatric inpatient hospitalization.


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Substance Misuse

ORG_CITY: CHARLESTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE There is a critical and longstanding need to improve treatment outcomes for co-occurring AUD/PTSD among veterans. Self-compassion is a transdiagnostic cognitive mechanism that may facilitate AUD recovery among veterans with co-occurring PTSD and may hold particular promise to amplify the benefits of intranasal oxytocin in combination with integrated behavioral treatment. This study will provide novel insight into the role of self- compassion in AUD/PTSD treatment outcomes among veterans with direct applications to improving clinical care and patient outcomes.

PI_NAMEs: FORKUS, SHANNON  (contact)

PROGRAM_OFFICER_NAME: KWAKO, LAURA ELIZABETH

PROJECT_TERMS: Academic Medical Centers;addiction;Alcohol abuse;alcohol abuse therapy;alcohol behavior;Alcohol consumption;alcohol intervention;alcohol relapse;alcohol research;alcohol use disorder;Alcohols;Antidotes;Award;Awareness;Behavior Therapy;Behavioral;behavioral response;Capital;care outcomes;Caring;Clinical;clinical care;clinical trial implementation;Clinical Trials;Cognitive;cognitive process;cognitive skill;Compassion;Complex;coping;craving;Data Analytics;design;Development;Diagnostic;direct application;Disease;Ecological momentary assessment;effective therapy;efficacy evaluation;Emotional;Emotions;Exhibits;experience;Extinction;Failure;Feeling;Fostering;Fright;Functional impairment;Goals;Grant;Health;high risk;improved;improved outcome;in vivo;Individual;innovation;insight;Institution;Intervention;Judgment;Literature;Maintenance;Manuscripts;Measurement;Medical;Mentorship;Methods;Military Personnel;National Institute on Alcohol Abuse and Alcoholism;Neurobiology;Neuropeptides;novel;Outcome;Oxytocin;Patient-Focused Outcomes;Pattern;persistent symptom;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Phase;Placebos;Post-Traumatic Stress Disorders;Predisposition;Process;Productivity;programs;public health priorities;Recording of previous events;Recovery;reduced substance use;relapse risk;Research;Research Personnel;Research Project Grants;resilience;Resources;response;Role;Safety;Sampling;Science;Self Efficacy;self-compassion;Severities;skills;South Carolina;stem;Stimulus;substance use treatment;sustained recovery;Symptoms;System;therapeutic target;Thinking;Training;training opportunity;Translating;treatment adherence;Treatment outcome;Treatment Protocols;Trust;Universities;Veterans

PROJECT_TITLE: The effect of self-compassion on integrated treatment outcomes among veterans with co-occurring AUD and PTSD.


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Transcription regulation is a key determinant of how genetic variability is interpreted by a cell: more than 90% of traits- and disease-associated genetic variants map outside of the coding genome; yet we still have a limited understanding of the how Transcription Factors find their target sequences in the genome haystack. In order to address this challenge, we will build upon our ability to design Zinc Finger containing Transcription Factors that bind arbitrary DNA sequences and combine it with cutting-edge live imaging approaches able to visualize where Transcription Factors bind in the cell. We will address whether Transcription Factors that turn genes on or off have evolved distinct strategies to find their targets, which will provide important design principles for novel biotechnologies based on Transcription Factor reprogramming.

PI_NAMEs: LIONNET, TIMOTHEE  (contact);NOYES, MARCUS BLAINE

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Address;Adopted;Affinity;Architecture;artificial intelligence model;base;Binding;Biological Assay;Biotechnology;Cells;Chromatin;Code;Complex;Data;design;Disease;DNA;DNA Binding;DNA Binding Domain;DNA Sequence;DNA-Protein Interaction;Engineering;Environment;Event;Exhibits;experimental study;gene repression;Genes;Genetic Determinism;Genetic Transcription;genetic variant;Genome;Goals;Health;Human;imaging approach;imaging platform;in vitro Assay;inorganic phosphate;interest;Kinetics;large scale data;Link;Maps;Measures;Microscopy;model design;Modeling;Mutation;novel;Nuclear;Output;programs;Property;protein protein interaction;Proteins;reconstitution;recruit;Repression;residence;Sampling;Scanning;single molecule;Site;sound;Specific qualifier value;Specificity;Synthetic Genes;Time;trait;transcription factor;Transcriptional Activation;Transcriptional Regulation;trend;Variant;Vertebral column;Visualization;Zinc Fingers

PROJECT_TITLE: Binding Kinetics in Transcription Activation and Repression

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE Drugs designed to treat Alzheimer’s disease reduce amyloid beta while showing modest clinical benefit. Thus, it is important to develop new therapeutic mechanisms that would synergize with amyloid beta reduction, providing a multidimensional treatment approach. This project will determine mechanisms by which a novel compound that we show to improve Alzheimer’s disease pathology such as increased Abeta42 levels and axonal organelle build up, modulates neuronal autophagy lysosomal pathways, thus providing mechanistic insight into functioning of a promising AD treatment target.

PI_NAMEs: SNEAD, AMANDA  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: abeta accumulation;Abeta synthesis;Adaptor Signaling Protein;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease therapy;Amyloid beta-42;Amyloid beta-Protein;Amyotrophic Lateral Sclerosis;Autophagocytosis;Autophagosome;Axon;Axonal Transport;Binding;Clinical;cognitive function;Comparative Study;Competitive Binding;Complementary therapies;Data;Defect;Dimensions;Disease;disease model;Distal;Drug Design;Drug Targeting;effective therapy;efficacy evaluation;Exhibits;experimental study;extracellular;familial Alzheimer disease;FDA approved;Frontotemporal Dementia;Functional disorder;Hela Cells;high throughput screening;Human;Image;Immunoprecipitation;Immunosuppressive Agents;Impaired cognition;Impairment;improved;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;insight;Investigation;Knock-out;Link;Lysosomes;Measures;Membrane Proteins;misfolded protein;Modeling;Morphology;Motility;mouse model;Movement;Mutation;Neurites;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuroglia;neuronal cell body;Neurons;novel;novel therapeutics;Organelles;Parkinson Disease;Pathogenesis;Pathologic;Pathology;Pathway interactions;Pharmaceutical Preparations;Positioning Attribute;presenilin-1;Process;Production;Property;protein aggregation;protein degradation;Proteins;Proteomics;retrograde transport;Route;Senile Plaques;Sirolimus;Swelling;synergism;targeted treatment;tau Proteins;Testing;Therapeutic;translational potential;Vesicle

PROJECT_TITLE: Evaluating autophagy modulation as a therapeutic strategy for Alzheimer's Disease using human neuronal culture models


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Rural Health;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_DEPT: SURGERY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: NARRATIVE Colorectal cancer is a leading cause of cancer death. Screening is effective at reducing colorectal cancer mortality, but is limited when patients who screen positive do not receive complete diagnostic follow-up. This study tests a multi-level intervention to promote evaluation and follow-up of positive colorectal cancer screening tests in a rural area that is medically underserved and has high rates of colorectal cancer mortality compared to urban and suburban areas.

PI_NAMEs: JAMES, AIMEE S (contact)

PROGRAM_OFFICER_NAME: SARMA, ELIZABETH ANNE

PROJECT_TERMS: Address;Adult;Area;behavior change;Behavioral Sciences;Cancer Burden;cancer care;Cancer Control;Cancer Etiology;cancer health disparity;cancer prevention;care delivery;Caring;Cessation of life;Clinic;Clinical;Clinical Medicine;Collaborations;colon cancer screening;Colonoscopy;Colorectal Cancer;colorectal cancer screening;Community Health Systems;Computerized Medical Record;County;Data;Death Rate;design;Diagnostic;disparity reduction;diverse data;Early Diagnosis;Economics;Electronic Health Record;Eligibility Determination;Epidemiology;Evaluation;Evidence based intervention;experience;Face;Fecal occult blood;Federally Qualified Health Center;follow-up;Growth;health care service;health care settings;health disparity;Health Personnel;Health Service Area;Health system;Healthcare;Healthcare Systems;Hot Spot;Household;Illinois;implementation evaluation;implementation outcomes;implementation science;improved;Incidence;Intervention;intervention effect;Intervention Studies;Interview;Malignant Neoplasms;Measures;Medical;medical schools;medically underserved;Medically Underserved Area;Mississippi;mortality;multidisciplinary;Outcome;Outcome Measure;Patient Care;patient registry;Patients;Population;Poverty;Primary Care;primary care clinic;primary care provider;primary care setting;primary outcome;Process;Proctor framework;Provider;Qualitative Methods;Randomized;Recommendation;Records;Research Design;Research Personnel;Resources;response;routine screening;Rural;rural area;Rural Community;rural dwellers;rural healthcare;rural underserved;screening;Screening Result;secondary outcome;Site;suburb;success;Surveys;Test Result;Testing;Time;Travel;trial design;United States;United States Preventative Services Task Force;Universities;uptake;Washington;Work

PROJECT_TITLE: Implementing multilevel colon cancer screening interventions to reduce rural cancer disparities


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Eye Disease and Disorders of Vision;Infectious Diseases

ORG_CITY: DETROIT

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative PM10 is a global, major toxic air pollutant, but little is known about its corneal effects. Our purpose is to use an in vivo mouse model to test the hypothesis that in the cornea, airborne PM10 triggers ROS, disrupting Nrf2 pathway signaling resulting in inflammation. We predict that this will exacerbate a painful blinding eye condition induced by the pathogen Pseudomonas aeruginosa (P. aeruginosa) and that SKQ1, an antioxidant, will reduce ROS and its sequelae before and/or after infection. We further predict that these data will have human applicability revealed by testing human corneal epithelial cells in culture.

PI_NAMEs: HAZLETT, LINDA D (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: 3-Dimensional;Acute;Affect;Air;Air Pollutants;Air Pollution;Airborne Particulate Matter;Animals;antimicrobial;Antioxidants;Bacterial Infections;Biological;Cardiovascular system;Cell Culture Techniques;Cell Survival;Clinical;Conjunctivitis;Cornea;corneal epithelium;cytokine;Cytoprotection;Data;Diameter;Disease;Disease Outcome;economic outcome;Emergency department visit;Epithelial Cells;Event;Exhibits;exposed human population;Exposure to;Eye;eye dryness;Genes;Goals;Health;Homeostasis;Human;Impairment;improved;In Vitro;in vivo;Infection;Inflammation;Inflammatory;inhibitor;insight;Interleukin-6;Irritants;Keratitis;Knowledge;Link;Lipid Peroxidation;Malondialdehyde;Messenger RNA;microbial;Mitochondria;Molecular;mouse model;Moxifloxacin;Mucous Membrane;Mus;novel;nuclear factor-erythroid 2;Oxidative Stress;Pain;particle;Particulate Matter;pathogen;Pathway interactions;Perforation;pollutant;protective effect;Proteins;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;PTGS2 gene;Reactive Inhibition;Reactive Oxygen Species;Reduced Glutathione;Regimen;Research;respiratory;response;Reverse Transcriptase Polymerase Chain Reaction;Role;Signal Pathway;Signal Transduction;Testing;therapeutic development;Thinness;TNF gene;Work

PROJECT_TITLE: Airborne Particulates, Corneal Oxidative Stress and Infection

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative  Children with autism spectrum disorder (ASD) are not typically diagnosed until 4 years of age and therefore miss a critical developmental time period important for optimizing outcomes. A core symptom of ASD is restricted and repetitive behaviors (RRBs), which impair daily functioning and impact all aspects of social and cognitive development. This proposal will explore early life brain-based biomarkers for ASD and RRBs and has the potential to improve the lives of diagnosed children and their families while providing an opportunity for the applicant to learn crucial skills necessary for an independent career as a developmental cognitive neuroscientist.

PI_NAMEs: KUPIS, LAUREN  (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: 12 year old;4 year old;Affect;Area;autism biomarker;Autism Diagnosis;autism diagnostic observation schedule;autism spectrum disorder;autism symptoms;autistic children;Behavior;behavior prediction;Behavioral;behavioral outcome;Biological;Biological Markers;Brain;brain abnormalities;brain based;brain behavior;career;career development;Caregivers;Categories;Child;Clinical;Cognition;Cognitive;cognitive development;Communication;critical period;daily functioning;Data;Data Analyses;Data Set;Development;Developmental Delay Disorders;Developmental Disabilities;Diagnosis;Diagnostic;Dimensions;Disease;Distress;Early Diagnosis;Early identification;early screening;experience;Family;flexibility;Foundations;Functional Magnetic Resonance Imaging;Goals;Heterogeneity;high risk;imaging modality;Impairment;improved;Individual;innovation;Intervention;Language Delays;Lateral;Learning;Life;life span;Literature;Machine Learning;Maps;Measures;Medial;meetings;Methods;Modeling;network dysfunction;neural;neural correlate;neuroimaging;Neurosciences;novel;Outcome;prospective;psychologic;repetitive behavior;Reporting;Research;Research Domain Criteria;Research Methodology;Rest;Risk;Sampling;Seminal;Severities;skills;Sleep;Social Adjustment;social communication;Social Development;statistics;Symptoms;targeted treatment;Techniques;Testing;Time;Toddler;Training;Work

PROJECT_TITLE: Brain-based biomarkers of restricted and repetitive behaviors in toddlers at risk for autism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


NIH_SPENDING_CATS: Bioengineering;Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE This grant will improve the safety and efficacy of histotripsy in a human scale large animal liver model by determining optimal strategies to address the reduced ablation precision caused by liver motion and to treat in critical locations in the liver not currently amenable to histotripsy or other ablation techniques. Also, a SCID-like HCC porcine model will be advanced and these strategies will be confirmed in that model, providing critical preclinical data to catalyze the adoption of histotripsy as a viable clinical treatment option for liver tumors. The knowledge gained from this work will also extend the use of histotripsy to a broader range of applications, including the treatment of tumors in other organs, such as the pancreas, kidney, breast, and thyroid.

PI_NAMEs: ZIEMLEWICZ, TIMOTHY J (contact)

PROGRAM_OFFICER_NAME: TATA, DARAYASH B

PROJECT_TERMS: Ablation;Acoustics;Address;Adoption;Animal Model;Animals;Architecture;Area;bile duct;Breast;Breathing;Cause of Death;Cessation of life;Cirrhosis;Clinical;Clinical Data;clinical translation;Clinical Treatment;Collagen;Compensation;cone-beam computed tomography;curative treatments;Data;Dependence;Development;Diameter;Disease;Dose;effective therapy;Eligibility Determination;Failure;Family suidae;Focused Ultrasound;Frequencies;Goals;Grant;Hepatic;high risk;Human;improved;in vivo;Injury;Intestines;Kidney;Knowledge;Lesion;Liver;liver cancer model;liver cancer patient;Liver neoplasms;Location;Malignant neoplasm of liver;Mechanics;Medical Device;Methods;Modality;Modeling;Motion;Normal tissue morphology;Operative Surgical Procedures;Organ;Pancreas;Patient Selection;Patients;Phase I Clinical Trials;Physiologic pulse;porcine model;pre-clinical;preclinical evaluation;Primary carcinoma of the liver cells;Procedures;prototype;Recovery;Recurrence;Resistance;respiratory;Risk;Safety;Shapes;side effect;Spain;Structure;System;Techniques;Testing;Thermal Ablation Therapy;Thinness;Thyroid Gland;Time;Tissues;Translations;tumor;Ultrasonic Therapy;ventilation;Work

PROJECT_TITLE: Developing Methods for Precise, Safe and Target-location Specific Histotripsy of Liver Tumors

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Heart Disease;Neurosciences;Patient Safety;Pediatric

PHR: Project Narrative Pediatric cardiac arrest in the out-of-hospital setting is a tragic event that occurs in thousands of children each year in the US. Many of these children are successfully resuscitated, but most die in the hospital or are left with severe lifelong disabilities due to the brain injury that occurs during the cardiac arrest. This study plans to determine whether longer durations of cooling improve brain recovery better than shorter durations of cooling and also seeks to find the best duration of cooling for comatose children following out of hospital cardiac arrest.

PI_NAMEs: YEATTS, SHARON DZIUBA (contact)

PROGRAM_OFFICER_NAME: PEMBERTON, VICTORIA

PROJECT_TERMS: Accident and Emergency department;Adaptive Behaviors;Address;Adult;Adverse event;age group;Asphyxia Neonatorum;Biostatistics Core;Brain;Brain Injuries;Cardiopulmonary Arrest;Case Report Form;cerebral ischemic injury;Cessation of life;Child;Childhood;Clinical;clinical investigation;clinical practice;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Data Monitoring Committees;Clinical Trials Network;Collection;Coma;Common Data Element;Companions;Coupled;Data;Data Coordinating Center;data management;data quality;Data Set;Databases;design;Development;Devices;Dose;electronic data;Emergency Care;Evaluation;Event;experience;FDA approved;Fever;Goals;Guidelines;Health Sciences;Heart Arrest;Hospitals;Impairment;implementation facilitation;improved;improved outcome;innovation;International;Investments;Knowledge;Left;Lifelong disability;Manuscripts;Medical;method development;Methods;Michigan;Modeling;Monitor;mortality;Multi-site clinical study;National Heart, Lung, and Blood Institute;National Institute of Neurological Disorders and Stroke;natural hypothermia;neonate;neurobehavioral;neurological recovery;neuroprotection;Newborn Infant;novel;Online Systems;organizational structure;out-of-hospital cardiac arrest;Outcome;Patient Selection;Patients;Periodicals;Population;pre-clinical;preference;prevent;Procedures;Protocols documentation;Public Health;Publications;Qualifying;Quality of life;Randomized;Recommendation;Recovery;Reporting;Research;Research Design;Research Priority;Resources;response;Resuscitation;Risk;Role;Safety;Selection Criteria;South Carolina;Specific qualifier value;Survivors;System;Temperature;Therapeutic;Time;treatment effect;trend;trial design;United States National Institutes of Health;Universities;Utah;Work

PROJECT_TITLE: 2/2 Pediatric Influence of Cooling duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(MA)]


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Disability Research;Neurosciences;Pain Research;Precision Medicine;Rehabilitation

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Phantom limb pain after amputation is prevalent and debilitating, leading to impairment in daily activities and increased anxiety and depression. This proposed research is relevant to the National Center for Medical Rehabilitation Research’s mission because it will investigate person-centered assessment of phantom limb pain factors, which can inform future recommendations for effective, personalized treatments. With an improved understanding of contributing factors to phantom limb pain and better-informed treatment techniques, individuals with amputations can experience optimized symptom management, a reduction in disability, and an improvement in quality of life.

PI_NAMEs: FALBO, KIERRA J (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: acceptability and feasibility;Address;Amputation;Anxiety;Biomedical Engineering;career;Cellular Phone;Characteristics;chronic pain;Clinic Visits;clinical care;clinical practice;Clinical Treatment;contextual factors;Data;Data Analyses;Data Discovery;design;Development;disability;Ecological momentary assessment;effective intervention;Engineering;Environment;Environmental Risk Factor;evidence base;experience;Focus Groups;Frequencies;Future;Goals;handheld mobile device;Health Care Costs;Heterogeneity;Impairment;improved;Individual;ineffective therapies;innovation;interest;Interview;Laboratories;limb amputation;Lower Extremity;Measures;Medical center;Mental Depression;Mentors;Mentorship;Method Acceptability;Methods;Migraine;Minnesota;Mission;multidisciplinary;Nature;Notification;Outcome;Pain;Pain management;pain reduction;Participant;participant retention;Patients;person centered;personalized medicine;Persons;Phantom Limb Pain;Population;Positioning Attribute;precision medicine;Predictive Factor;programs;Prosthesis;Protocols documentation;Public Health;Qualitative Research;Quality of life;Recommendation;recruit;rehabilitation research;rehabilitation science;Reporting;Research;research data dissemination;Research Infrastructure;Research Personnel;response;retention rate;Review Literature;Rheumatoid Arthritis;Sampling;Science;skills;stem;Structure;success;Survey Methodology;Surveys;symptom management;Techniques;Testing;therapy design;Time;Training;Universities;Work

PROJECT_TITLE: Examining Factors of Phantom Limb Pain through Person-Centered Assessment


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE This project combines measures of muscle activation with advanced spinal cord functional magnetic resonance imaging (fMRI) to study upper limb motor impairments following a stroke. This will be the first study to use spinal cord fMRI to investigate which neural pathways, connecting the brain to the musculature via the spinal cord, are driving motor impairment in individuals with post-stroke weakness on one side. Through improved understanding of neural pathway utilization post-stroke, the overall goal of this project is to inform the development of more targeted rehabilitative treatments using advanced imaging techniques.

PI_NAMEs: HEMMERLING, KIMBERLY JIYUN (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Address;Affect;analysis pipeline;arm paresis;Automobile Driving;Bilateral;blood oxygen level dependent;Brachial Paresis;Brain;Cervical;Cervical spinal cord structure;Characteristics;Chronic;Chronic disability;Communication;Contralateral;Dedications;denoising;density;Development;Diffuse;Distal;Electromyography;Environment;experience;Fellowship;Fostering;Functional Magnetic Resonance Imaging;Generations;Goals;grasp;Hand;hand grasp;Handedness;hemiparetic stroke;Human;Imaging Techniques;Impairment;improved;indexing;Individual;Injury;innovation;insight;interest;Intervention;Ipsilateral;Isometric Exercise;Joints;Leadership;Limb structure;Link;Magnetic Resonance Imaging;Maps;Measures;Mediating;Medical;Mentorship;Methods;mortality;Motor;Motor Activity;motor control;motor deficit;motor function recovery;motor impairment;Motor Neurons;Motor Pathways;Movement;Muscle;National Research Service Awards;nerve injury;neural;Neural Pathways;neuroimaging;neuromechanism;Neuronal Plasticity;Neurophysiology - biologic function;Neurosciences;neurovascular;neurovascular injury;Noise;novel;Paresis;Participant;Pathway interactions;Pattern;Physiological;Positioning Attribute;post stroke;Predisposition;Reaction;Recovery of Function;Rehabilitation therapy;Research;Research Project Grants;Research Proposals;reticulospinal tract;Severities;Side;signal processing;Signal Transduction;Skeletal Muscle;Spinal;Spinal Cord;Statistical Models;Stroke;stroke hemiparesis;success;synergism;targeted treatment;Techniques;Therapeutic Intervention;Training;United States;Universities;Up-Regulation;Upper Extremity;Work

PROJECT_TITLE: Probing an increased reliance on reticulospinal motor pathways in chronic hemiparetic stroke with advanced spinal cord functional MRI