NIH_SPENDING_CATS: Asthma;Biotechnology;Climate-Related Exposures and Conditions;Clinical Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Lung;Prevention;Social Determinants of Health

ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

PHR: Project Narrative Asthma exacerbations are responsible for the major health impacts associated with the disease, and increased air pollution from wildfire smoke is a major contributor to exacerbations. Patients with asthma experience variable sensitivity to air pollution, and public health recommendations fail to appropriately target high risk patients. Using primary human tissue culture, next-generation sequencing-based techniques and bioinformatic tools, we will characterize genetic risk factors that connect wildfire air pollution with asthma exacerbations and identify mechanisms and potential therapeutic targets for pollution-associated asthma exacerbations.

PI_NAMEs: GUPTA, ARNAV  (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: Address;Air;Air Pollutants;Air Pollution;airway epithelium;Alleles;Aryl Hydrocarbon Receptor;associated symptom;Asthma;asthma exacerbation;Binding;Binding Sites;Bioinformatics;bioinformatics tool;Biological Assay;Cell Culture Techniques;Cell Line;Cell model;Chromatin;climate change;Clinical;Clinical Data;Clustered Regularly Interspaced Short Palindromic Repeats;Consensus;Dexamethasone;Disease;disease model;Epithelial Cells;experience;Family;Gene Expression;Genes;Genetic Polymorphism;genetic risk factor;Genetic Transcription;genetic variant;genome editing;Genomic DNA;Genomics;Glucocorticoid Receptor;Grant;Health;high risk;Housing;Human;human tissue;IL8 gene;Individual;Inflammation;Interleukin-8;Laboratories;Liquid substance;Luciferases;Mediating;Mediator;Mentors;Methodology;Methods;Minor;Modeling;Morbidity - disease rate;mortality;next generation sequencing;NF-kappa B;novel;particle;particle exposure;Particulate;Patients;pharmacologic;Physiological;Plasmids;pollutant;Pollution;Population Study;Predisposition;Public Health;receptor expression;Recommendation;Regulation;Regulator Genes;Reporter;response;Risk Estimate;Role;Series;Severities;Single Nucleotide Polymorphism;Smoke;Susceptibility Gene;Symptoms;Techniques;Testing;therapeutic target;tissue culture;tool;Toxic effect;transcription factor;Variant;Wildfire;wood smoke

PROJECT_TITLE: Transcriptional Responses to Wildfire Pollution in Airway Epithelial Cells Identify Genetic Risk Factors and Mechanisms of Asthma Exacerbations


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Kidney Disease

ORG_CITY: ROCHESTER

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: The kidney has a limited ability to repair that primarily relies on scattered tubular-like cells (STCs), which can proliferate and their progeny re-differentiate into tubular epithelial cells to replace lost neighboring injured tubular cells. Experimental RAS impairs the reparative capacity of swine STCs by damaging their mitochondria, but the processes underpinning RAS-induced STC mitochondrial damage remain unclear. The proposed studies will determine the mechanisms by which increased expression of the mitochondria-related microRNA miR-181c in RAS-STCs compromises STC mitochondrial structure and function, and their contribution to STC function and reparative capacity.

PI_NAMEs: EIRIN, ALFONSO  (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: 3-Dimensional;Address;alpha ketoglutarate;Attenuated;Bioenergetics;Biogenesis;cell injury;Cell Nucleus;Cell Physiology;Cells;Characteristics;clinically relevant;cofactor;Cytosine;Cytosol;Data;Deterioration;Development;Dioxygenases;DNA;Down-Regulation;Elderly;End stage renal failure;Enhancers;Enzymes;Epigenetic Process;Epithelial Cells;Event;Exhibits;experimental study;Family suidae;Fibrosis;Functional disorder;Functional Imaging;Gene Expression;Gene Silencing;Gene Targeting;Genes;Genetic Transcription;genome-wide;Harvest;Histones;Homeostasis;Hypertension;Imaging Techniques;Impairment;improved;In Vitro;in vivo;Inflammation;Infusion procedures;inhibitor;injured;Injury to Kidney;insight;Kidney;Kidney Diseases;kidney repair;Measures;Methylation;MicroRNAs;migration;miRNA expression profiling;Mitochondria;Mitochondrial DNA;Morbidity - disease rate;mortality;novel;novel strategies;Nuclear;oxidation;Oxidation-Reduction;paracrine;Phenotype;Pilot Projects;Polyribonucleotide Nucleotidyltransferase;Population;porcine model;posttranscriptional;preservation;Process;Production;progenitor;Proliferating;promoter;protective effect;Protein Import;Regulator Genes;Renal Artery Stenosis;Renal function;renal ischemia;repaired;reparative capacity;Role;Structural defect;Structure;System;Techniques;Testing;tool;Tubular formation

PROJECT_TITLE: Role of mitochondrial microRNAs (mitomiRs) in endogenous renal repair

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Hematology;Rare Diseases

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: NARRATIVE Analysis of multiple myeloma (MM) patients (n=815) from across the disease spectrum reveals Unc-51 Like Kinase-3 (ULK3) as being significantly expressed in newly diagnosed and refractory MM and, our emerging studies define ULK3 as a key regulator of autophagy and MM cell viability in vitro. Excitingly, our team has developed novel ULK3 inhibitors (SG3/MA9) that rapidly inhibit autophagy and can also block the activity of the bromodomain containing protein 4 (BRD4), which is also expressed in refractory MM and is an important driver of the MYC oncogenic program. Based on preliminary in vitro and in vivo studies demonstrating the efficacy of SG3/MA9 for the treatment of naïve and refractory MM, the proposed studies herein for the first time will define the role of ULK3 in MM progression and test the efficacy of novel dual BRD4/ULK3 inhibitors in treating MM and resensitizing resistant disease to standard of care therapies using in vitro and in vivo approaches.

PI_NAMEs: LYNCH, CONOR C (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Ablation;Agreement;Animal Model;Apoptosis;Autologous;Automobile Driving;Autophagocytosis;Biological Assay;bone;Bone Diseases;Bone Marrow;Bortezomib;Bromodomain;Bromodomains and extra-terminal domain inhibitor;c-myc Genes;Cell Line;Cell Survival;Cells;Chloroquine;Clinic;clinically relevant;clinically significant;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Coin;cytochemistry;Data;Data Set;defined contribution;Development;Disease;Disease Progression;Disease Resistance;Drug resistance;efficacy evaluation;efficacy testing;Evolution;Flow Cytometry;Generations;Genetic;genetic approach;Growth;Half-Life;Human;Immunocompetent;Immunohistochemistry;Impairment;improved;In Vitro;in vivo;inhibition of autophagy;inhibitor;lenalidomide;Malignant Neoplasms;Mediating;Medicine;Melphalan;Modeling;multicatalytic endopeptidase complex;Multiple Myeloma;Mus;neoplastic cell;Newly Diagnosed;Newly Diagnosed Disease;novel;Oncogenic;Osteoblasts;Osteocalcin;Osteoclasts;Osteolysis;Pathway interactions;Patient Isolation;Patients;Phosphotransferases;Plasma Cells;Program Sustainability;programs;Proliferation Marker;Proteasome Inhibitor;Proteins;Reagent;Refractory;Refractory Disease;Resistance;resistance mechanism;response;Roentgen Rays;Role;skeletal;small molecule inhibitor;standard of care;Stress;synergism;targeted treatment;tartrate-resistant acid phosphatase;Testing;Therapeutic;Time;Tissue Microarray;Tissues;Toxic effect;transcriptome sequencing;Translations;tumor growth;tumorigenic;Work

PROJECT_TITLE: Role of ULK3 in Sensitive and Refractory Multiple Myeloma

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative The residual inflammatory risk for atherothrombotic events is common even in people with well-controlled cholesterol levels. Therefore, the identification of novel targets that control chronic inflammation is of critical importance in the cardiovascular research field. Emerging evidence shows that failed resolution of chronic inflammation is an important driving force for atherosclerotic plaque progression; hence, the goal of our proposed study is to uncover novel mechanisms that contribute to impaired resolution of inflammation as well as strengthened inflammation in progressing plaques.

PI_NAMEs: CAI, BISHUANG  (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: Address;Affect;Anti-Inflammatory Agents;Apoptotic;Area;Arterial Fatty Streak;Atherosclerosis;atherosclerotic plaque rupture;Autophagocytosis;C-terminal;Cardiac;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Cause of Death;Cell Physiology;Cell surface;cell type;Cells;Cholesterol;Chronic;Clinical;cytokine;Data;Disease;driving force;Enzymes;Event;Gene Expression;Goals;Human;human disease;Human Genetics;Immune response;Impairment;In Vitro;infection risk;Inflammation;Inflammatory;Inflammatory Response;inhibition of autophagy;Integral Membrane Protein;Interruption;Lesion;Link;lipid mediator;Lipids;Lipoproteins;Macrophage;Mediating;Mediator;Membrane;Metalloproteases;Mus;Myelogenous;Necrosis;novel;novel therapeutic intervention;Pathway interactions;Persons;Phenotype;Play;Population;Positioning Attribute;prevent;Process;Protein Family;Protein Tyrosine Kinase;Proteins;receptor;Recycling;Research;Research Personnel;Residual state;Resolution;retrograde transport;Risk;Role;selective expression;single-cell RNA sequencing;sortilin;Testing;Therapeutic;tissue repair;trafficking;transcriptome sequencing

PROJECT_TITLE: EHD1-mediated Inflammation and Resolution in Atherosclerosis

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Neurosciences;Rehabilitation;Serious Mental Illness

ORG_CITY: DURHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Difficulties in managing emotions contribute to the development and maintenance of affective and stress disorders, and, therefore, constitute a significant public health problem in need of novel, rapid interventions. To address this transdiagnostic need, we plan to characterize neural changes that result from practice of emotion regulation skills enhanced with neurostimulation targeted towards the emotion regulation network. The findings of this study will be used to refine a combined psychotherapy and brain stimulation intervention.

PI_NAMEs: NEACSIU, ANDRADA DELIA (contact)

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: Address;Adult;Affective;affective neuroscience;Alcohol consumption;Amygdaloid structure;Anorexia;Anxiety Disorders;anxious;Area;Arousal;Autobiography;Behavior Therapy;Behavioral;biobehavior;Bipolar I;Brain;Brain imaging;burden of illness;Clinical;clinical diagnostics;clinical practice;clinically significant;Cognitive;cognitive enhancement;cognitive neuroscience;Cognitive Therapy;Combined Modality Therapy;Communities;Control Groups;Depressed mood;Development;Diagnostic;Disease;Distress;Down-Regulation;DSM-V;electric field;emotion dysregulation;emotion regulation;Emotional;emotional functioning;Emotions;Equilibrium;Exclusion;Exhibits;expectation;flexibility;follow-up;Frequencies;Functional disorder;functional gain;Functional Magnetic Resonance Imaging;Goals;Grant;heart rate variability;imaging study;improved;indexing;individual variation;insight;Instruction;Insula of Reil;Integrative Therapy;Intervention;Interview;Knowledge;Learning;Left;Literature;Maintenance;Major Depressive Disorder;Measurement;Measures;Medial;Mediating;Memory;Modeling;Monitor;Mood Disorders;neural;neural network;neurobehavioral;Neurobiology;Neuronavigation;neurophysiology;Neurophysiology - biologic function;neuroregulation;noninvasive brain stimulation;novel;novel strategies;novel therapeutic intervention;Outcome;Participant;Pathway interactions;Patient Self-Report;Patients;personalized biomarkers;Physiological;placebo controlled trial;Prefrontal Cortex;Process;Psychiatric therapeutic procedure;psychoeducation;Psychopathology;Psychophysiology;Psychotherapy;Psychotic Disorders;Public Health;Randomized;Recovery;Regulation;remediation;repetitive transcranial magnetic stimulation;Reporting;Research;response biomarker;Sampling;Scanning;sex;skills;Stress;stress disorder;stressor;Structure;substance use;success;Testing;therapy duration;Time;tool;Training;Translating;Visit;Work

PROJECT_TITLE: Neurostimulation Enhanced Cognitive Restructuring for Transdiagnostic Emotional Dysregulation: A Component Analysis

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Burden of Illness;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_CITY: MADISON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Narrative This project aims to improve understanding of the impacts of the Earned Income Tax Credit (EITC) on the provision and utilization of formal care for older adults with and without Alzheimer’s disease and Alzheimer’s disease-related dementias (AD/ADRD). It uses advanced empirical methods and two large, nationally representative data sets and leverage a large number of plausibly exogeneous policy changes in the EITC at the federal and state levels in the past two decades that may induce changes in formal care for older adults. The findings from this project will provide valuable information to policymakers interested in designing effective population-level policies to support formal care providers, especially the most vulnerable low-income care providers who bear the heaviest burdens of caregiving but have not been a focus of research in the past.

PI_NAMEs: WANG, YANG  (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Address;Affect;Age;aged;Alzheimer's Disease;Alzheimer's disease related dementia;care giving burden;care providers;care recipients;Caregivers;Caring;Chronic Disease;coping;Cost Analysis;cost effective;Costs and Benefits;Data;Data Set;design;Diagnosis;Dimensions;Educational Status;Ethnic Origin;Event;Expenditure;experience;Family;Family Sizes;Formal caregiver;Friends;Gender;Goals;Health;Health and Retirement Study;Health Care Costs;health data;Health Personnel;Healthcare Systems;Home;human old age (65+);improved;Income;Income Tax;Individual;informal care;innovation;insight;Institution;interest;Knowledge;Lead;Life;Life Expectancy;Literature;Long-Term Care;Low income;Low Income Population;Marital Status;Marketing;Mental Health;Methods;National Institute on Aging;older adult;Outcome;Patients;Personal Satisfaction;Persons;physical conditioning;Policies;policy implication;Policy Maker;Population;population survey;Positioning Attribute;Poverty;pressure;Prevention;programs;Provider;Quasi-experiment;Race;Research;Stress;Taxes;Testing;Time;United States National Institutes of Health;Wages;Work

PROJECT_TITLE: Effects of EITC on Formal Long-Term Care for Older Adults with and without AD/ADRD

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;HIV/AIDS;Immunotherapy;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: PITTSBURGH

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Chronic HIV infection causes T cell exhaustion resulting in impaired control of the ongoing viral infection as well as increased susceptibility to opportunistic infections. Mechanisms that regulate exhaustion are not yet fully characterize. In this study, we will determine pathways involved in energy metabolism in T cells during chronic HIV and reveal their role in T cell exhaustion.

PI_NAMEs: LARSON, ERICA CHRISTINE (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: Affect;Anatomy;Animals;Antigens;antiretroviral therapy;Autopsy;Bacillus;Biological Assay;Blood;CD8-Positive T-Lymphocytes;Cell Communication;Cell Physiology;Cell Separation;Cell Survival;Cells;Cellular Immunity;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cellular Metabolic Process;Chronic;co-infection;Communicable Diseases;Complex;Disease Progression;Energy Metabolism;Environment;exhaust;exhaustion;Exhibits;Fatty Acids;FDA approved;Flow Cytometry;Genus Hippocampus;global health;Glycolysis;Goals;HIV;HIV Antigens;HIV Infections;HIV/AIDS;HIV/TB;Host Defense;Human;Immune;immune activation;Immunity;Immunologics;Impairment;improved;Individual;Infection;Investigation;lymph nodes;Macaca fascicularis;Measures;Mediating;Metabolic;Metabolic Pathway;Metabolism;Metformin;Mitochondria;Modality;Modeling;Monitor;Mycobacterium tuberculosis;nonhuman primate;Opportunistic Infections;oxidation;Oxidative Phosphorylation;pathogen;Pathology;Pathway interactions;Patients;Peptides;Peripheral;Persons;PET/CT scan;Pharmaceutical Preparations;Phenotype;Phosphorylation Inhibition;Plasma;Play;Predisposition;Prevalence;Process;programmed cell death protein 1;programs;receptor;response;Role;Sampling;Signal Transduction;single-cell RNA sequencing;SIV;Stress;T-Lymphocyte;Testing;Time;Tissues;tool;Tuberculosis;tuberculosis immunity;uptake;Viral Load result;Viral reservoir;Virus Diseases;X-Ray Computed Tomography

PROJECT_TITLE: Re-educating T cell-mediated immunity in SIV by modulating metabolic pathways

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Genetics;Hematology;Lymphatic Research;Lymphoma;Machine Learning and Artificial Intelligence;Orphan Drug;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE This project engages the expertise of its academic and industrial partners to develop therapeutic agents for undruggable oncoproteins. Artificial intelligence (AI) will advance small molecule discovery for cancer drivers into investigational new drug-enabling studies and clinical trials. The success of this project will catalyze the adoption of AI in drug discovery to target a wide range of high-priority oncoproteins in the era of precision medicine.

PI_NAMEs: LI, YONG  (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Abnormal Cell;adaptive immune response;adaptive immunity;Adaptor Signaling Protein;Address;Adoption;Affect;Agammaglobulinaemia tyrosine kinase;Age;Amino Acid Substitution;Artificial Intelligence;Artificial Intelligence platform;Attenuated;B-Cell Activation;B-Cell NonHodgkins Lymphoma;B-Lymphocytes;Binding Sites;Biochemical Reaction;Biological Assay;Blood typing procedure;Body part;Cancer Biology;cancer therapy;causal variant;Cell Survival;Cells;Cessation of life;Classification;Clinical;Clinical Trials;Collaborations;college;Cultured Cells;Data;deep learning;drug candidate;drug development;drug discovery;Drug Kinetics;Extranodal;Genes;Growth;Hematopoietic Neoplasms;Hodgkin Disease;Immune response;Immune system;Immunity;In complete remission;In Vitro;in vivo;Indolent;Industrialization;Inflammation;inhibitor;Innate Immune Response;Investigational Drugs;Knowledge;large cell Diffuse non-Hodgkin's lymphoma;Leucine;Link;Lymphocyte;Lymphoma;Lymphoma cell;Lysine;Malignant Neoplasms;Mediating;Medicine;Missense Mutation;mouse model;multicatalytic endopeptidase complex;Mutate;Mutation;Myelogenous;Natural Immunity;neural network;Non-Hodgkin's Lymphoma;novel therapeutics;Nuclear;Oncogenes;Oncogenic;Oncoproteins;Outcome;Pathogenesis;Patients;Phosphotransferases;Physiological;Polyubiquitin;Positioning Attribute;precision medicine;Proline;protein degradation;Proteins;Publishing;Reed-Sternberg Cells;response;Ring Finger Domain;screening;Signal Transduction;Site;small molecule;Solid;Structure;success;Technology;Testing;Therapeutic Agents;therapeutic development;therapeutic target;Toll-like receptors;Toxic effect;Transgenic Organisms;tumorigenesis;Ubiquitination;United States;virtual;Waldenstrom Macroglobulinemia;Work;Xenograft procedure

PROJECT_TITLE: Therapeutic Targeting a Non-Hodgkin Lymphoma Driver Using AI


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: BOSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: Project Narrative Accurate partitioning of the genetic information (chromosomes) during cell division is critical for normal human development and errors in chromosome segregation are tightly correlated with cancer. This project will investigate molecular events that are required to package chromosomes in preparation for segregation during cell division.

PI_NAMEs: BLOWER, MICHAEL DEMIAN (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Affect;Architecture;ATPase Domain;Binding;Binding Proteins;Biochemical;Biological;cancer cell;Cell Cycle;Cell division;Cell Line;Cell Nucleus;Cells;Chromatin;Chromatin Loop;chromatin remodeling;Chromatin Structure;Chromosome Condensation;Chromosome Segregation;Chromosome Structures;Chromosomes;cohesin;Complex;condensin;de novo mutation;design;Development;DNA;DNA Polymerase II;Enzymes;Euchromatin;Event;Excision;experimental study;Gene Expression;Gene Expression Regulation;Genetic;genetic analysis;Genetic Epistasis;genetic information;Genetic Transcription;genetically modified cells;Genome;Genome Stability;Genomic approach;Genomics;Goals;Heterochromatin;Histones;Human;Human Development;human error;Image;In Vitro;insight;Interphase;Interphase Chromosome;Knowledge;Link;Malignant Neoplasms;Mediating;Messenger RNA;Mitosis;Mitotic;Mitotic Chromosome;Molecular;Mus;Mutation;Neurodevelopmental Disorder;non-histone protein;Nuclear;Nuclear Protein;Nuclear Structure;Nucleic Acid Biochemistry;Nucleic Acids;Pathway Analysis;Pathway interactions;Phenotype;Phosphorylation;Physical condensation;Preparation;Process;programs;Prophase;protein oligomer;Proteins;reconstitution;Regulation;RNA;RNA Binding;RNA Splicing;segregation;Sister Chromatid;Structure;Surface;telophase;Time;transcription factor;Transcriptional Activation;Transcriptional Regulation;Untranslated RNA;Work

PROJECT_TITLE: Analysis of chromatin-RNA interactions during the cell cycle.

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: ALBANY

ORG_DEPT: BIOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

PHR: Project Narrative There is a growing interest in the different types of non-canonical translation, including repeat associated non- AUG translation which is associated with RNA structure, translation in multiple frames and microsatellite expansion diseases. Having identified other forms of multi-frame non-canonical translation outside of RAN translation, the overarching goal of this proposal is to determine the RNA structures, protein networks and therapeutically relevant modifiers that govern different types of multi-frame translation. Together this information will provide a deeper understanding of the mechanism of multi-frame translation and the processes that govern human cellular proteome diversity, which in turn will enable informed therapy development across multiple microsatellite expansion diseases.

PI_NAMEs: SHORROCK, HANNAH  (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Biology;CAG repeat;Cell Line;Clustered Regularly Interspaced Short Palindromic Repeats;comparative;Coupled;Data;design;Detection;Disease;disease model;Genetic;genome wide screen;genome-wide;Goals;Human;Human Genome;Immunologics;Induced pluripotent stem cell derived neurons;Initiator Codon;innovation;interest;Knowledge;Mass Spectrum Analysis;Mediating;Methods;Microsatellite Repeats;Modeling;Molecular;molecular modeling;Mutagenesis;Nervous System Disorder;novel;Pathogenesis;Pathogenicity;Peptide Initiation Factors;permissiveness;Play;polyglutamine;polysome profiling;Process;Production;Proteins;Proteome;ran GTP-Binding Protein;Reading Frames;Reporter;Research;Ribosomes;RNA;Role;Sedimentation process;Small Interfering RNA;Structure;System;Testing;Therapeutic;Therapeutic Intervention;therapy development;Tissues;Transcript;translation factor;Translations;Treatment Efficacy;Untranslated RNA;Western Blotting

PROJECT_TITLE: Mechanistic Basis for Non-Canonical Translation in Neurological Disease

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Rare Diseases;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: Aurora

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Narrative A deficit in cerebral blood flow hemodynamics is an early feature of cerebral small vessel disease—a leading cause of stroke and age-related cognitive decline—which suggests that cerebrovascular dysfunction has a key role in disease pathogenesis. Here we describe how some pericytes (cells that wrap around the capillaries) constrict in response to blood pressure to adjust blood flow through the dense capillary network, and demonstrate that this mechanism is disrupted in a mouse model of small vessel disease, leading to loss of blood flow control. Therefore, this work may identify novel targets on pericytes for therapies aimed at protecting or restoring blood flow in small vessel disease conditions.

PI_NAMEs: DABERTRAND, FABRICE  (contact)

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TERMS: Ablation;Address;Age-associated memory impairment;Agonist;Animals;arteriole;autocrine;Award;Blood;Blood capillaries;Blood flow;blood flow measurement;Blood Pressure;Brain;Brain Diseases;Brain imaging;brain pericytes;CADASIL;Capillary Endothelial Cell;Cell Separation;Cells;cerebral autoregulation;cerebral hemodynamics;Cerebral small vessel disease;Cerebrovascular Circulation;Cerebrovascular Disorders;Characteristics;clinically relevant;comorbidity;Complex;Computer Models;constriction;Data;Deposition;Diameter;Dimensions;Disease;DTR gene;Endothelial Cells;Energy Supply;Epidermal Growth Factor Receptor;Event;Extracellular Domain;Extracellular Matrix;Extracellular Matrix Proteins;Fatigue;Feedback;Foundations;Genetic;Health;hemodynamics;Hemorrhage;Homeostasis;Human;Impairment;in vivo;Inherited;inhibitor;innovation;inorganic phosphate;Inositol;insight;ITPR1 gene;knockout animal;Laser Scanning Microscopy;Lead;Left;Ligands;Light;Link;Matrix Metalloproteinase Inhibitor;Mediating;Membrane;Metalloproteases;Microcirculation;Microvascular Dysfunction;Modeling;mouse model;Mus;Mutation;Neuroglia;Neurons;NOTCH3 gene;novel;novel therapeutics;Nutrient;overexpression;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Pericytes;Phospholipase C;PLC gamma1;Preparation;pressure;Process;Protein Isoforms;receptor;Receptor Activation;Receptor Inhibition;Regulation;Relaxation;Research;Resistance;response;Role;Signal Transduction;Smooth Muscle Myocytes;Stroke;Testing;Time;TIMP3 gene;Tissues;Transgenic Organisms;two-photon;Up-Regulation;Variant;Vascular Dementia;vasoactive agent;vasoconstriction;Vasoconstrictor Agents;virtual;voltage;Work

PROJECT_TITLE: Capillary control of cerebral blood flow, and its disruption in small vessel disease

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Gene Therapy;Genetics;Human Genome;Immunotherapy

ORG_CITY: SAN FRANCISCO

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

ORG_STATE: CA

PHR: NARRATIVE The next generation of genetically engineered T cell therapies for cancers will depend on synthetic programs that enhance their potency and persistence. We recently performed high-throughput studies to discover genes that enhance T cell stimulation-dependent responses and enhance their functional persistence. Here, we will use a systematic approach to evaluate how these genes – and synthetic DNA constructs that integrate them into novel circuits that respond to stimulation by cancer targets – alter the ability of engineered T cells to treat cancer in multiple preclinical models.

PI_NAMEs: MARSON, ALEXANDER  (contact);ROYBAL, KOLE T

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Acceleration;Address;Adoptive Cell Transfers;Adverse event;antigen-specific T cells;Antigens;Biological;cancer immunotherapy;Cancer Model;cancer therapy;candidate validation;CD28 gene;Cell Physiology;Cell Therapy;Cells;Cellular immunotherapy;chimeric antigen receptor T cells;Chromatin;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR interference;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;CTLA4 gene;Cues;cytokine;design;Development;DNA Sequence;engineered T cells;Engineering;Environment;Evaluation;Face;fitness;Functional disorder;functional genomics;gain of function;gene discovery;gene network;Genes;Genetic;Genetic Complementation Test;genetic element;Genetic Screening;Genetic study;Genetic Transcription;Genome;genome wide screen;genome-wide;Goals;high throughput technology;Human;improved;In Vitro;in vivo;insight;Interferon Type II;Interleukin-2;knock-down;Knock-in;Knock-out;Learning;Libraries;Locales;loss of function;Malignant Neoplasms;member;Methods;mouse model;next generation;novel;overexpression;pre-clinical;Pre-Clinical Model;Preclinical Testing;Production;programs;promoter;rational design;receptor;Regulation;Repression;Resistance;response;Safety;Science;single-cell RNA sequencing;Site;small hairpin RNA;synthetic biology;synthetic construct;Synthetic Genes;T cell therapy;T-Cell Activation;T-Lymphocyte;Technology;Testing;Therapeutic;therapeutic gene;tool;transcription factor;Transgenic Organisms;Translating;Treatment Efficacy;tumor;Tumor Antigens;tumor microenvironment;VAV1 gene;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Decoding and reprogramming T cells through synthetic biology for cancer immunotherapy

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Heart Disease;Hypertension;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CHICAGO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative The long-term goal of this research is to elucidate the mechanisms by which cardiovascular risk factors lead to increased risk for dementia with aging. By understanding these mechanisms, it will be possible to help inform design of new approaches to delay or prevent the debilitating impacts of dementia, including that caused by Alzheimer's disease. The end result will be to improve quality of life for those suffering from dementia, and the subsequent impacts on their caregivers.

PI_NAMEs: JARVIS, KELLY BROOKE (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: 3-Dimensional;4D MRI;Abeta clearance;Acceleration;Adult;Affect;Age;age related changes;Aging;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Aorta;Blood;Blood flow;Blood Flow Velocity;Blood Pressure;Blood Vessels;Brain;brain abnormalities;Brain imaging;brain magnetic resonance imaging;Buffers;cardiovascular imaging;cardiovascular risk factor;Cardiovascular system;Caregivers;cerebral atrophy;cerebral hemodynamics;cerebrovascular;Cerebrovascular Disorders;Cerebrum;Chest;Clinical;Cognitive aging;Complex;Coupling;Data;Dedications;Dementia;dementia risk;design;Development;diagnostic tool;doctoral student;Evaluation;Foundations;Future;Goals;Head and neck structure;Heart;hemodynamics;Hypertension;Imaging Techniques;Impairment;improved;Individual;innovation;insight;late life;Lead;Link;Magnetic Resonance Imaging;Maps;Measures;Methodology;Methods;middle age;modifiable risk;neuroimaging;Neurons;normal aging;novel;novel strategies;Pathology;Pattern;physical inactivity;Physiologic pulse;Physiological;Pilot Projects;Postdoctoral Fellow;prevent;Production;programs;Protocols documentation;Pulsatile Flow;Quality of life;Radiology Specialty;Research;Scanning;Structure;Techniques;tool;Training;White Matter Hyperintensity

PROJECT_TITLE: Heart-brain MRI for the evaluation of hemodynamic coupling in aging and Alzheimer's disease

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Muscular Dystrophy;Rare Diseases

ORG_CITY: URBANA

ORG_NAME: CARLE FOUNDATION

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE  A muscle’s internal structure is an important determinant of its function. Advanced magnetic resonance imaging methods offer the potential for assessing these functions, but require development. We will create new capabilities for studying muscle structure and function non-invasively, in health and disease.

PI_NAMEs: DAMON, BRUCE M. (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Adult;Affect;Algorithms;Applied Research;Architecture;Atrophic;Basic Science;Biological;Biomechanics;Collaborations;Communities;Complement;Computer software;computerized data processing;Data;data integration;Data Set;Development;Diameter;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;distributed data;Duchenne muscular dystrophy;Elements;Fatty acid glycerol esters;Fiber;Foundations;Free Will;Generations;Growth;Health;Health Status;Human;Image;imaging modality;Impairment;improved;in vivo;Infiltration;Inflammation;Injury;insight;Knowledge;Length;life span;Magnetic Resonance Imaging;Mechanics;meetings;Methods;Muscle;Muscle Fibers;Muscle function;muscular structure;Musculoskeletal;Myopathy;novel;Outcome;Oxygen;Pathologic;Pathology;Patients;Pattern;Peripheral;Physiological;Physiology;prevent;Production;Property;public health relevance;Research;Research Personnel;Resources;Rest;Risk;Sarcomeres;Shapes;Software Tools;Source;spatial relationship;Structure;Techniques;Technology;technology platform;Testing;Three-Dimensional Image;tool;Translational Research;translational study;Water;whole body imaging;Work

PROJECT_TITLE: Development and Application of Muscle Diffusion Tensor MRI

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Inflammatory bowel disease (IBD) is a debilitating chronic gastrointestinal disease for which there is a large unmet clinical need. The enzyme glutamate carboxypeptidase II (GCPII) is robustly overexpressed in IBD and its inhibition is therapeutic in multiple preclinical animal models. The work in this proposal will improve our understanding of GCPII dysregulation and function in human and mouse IBD and will inform efforts to develop targeted GCPII inhibitors for clinical IBD treatment.

PI_NAMEs: PETERS, DIANE E (contact)

PROJECT_TERMS: Acute;Adoptive Transfer;Adult;Affect;Age;Animal Model;antagonist;Applications Grants;Award;Bacteroides fragilis;Biological Products;Biology;Biomedical Research;Biopsy;career;cell type;Cells;Characteristics;Chemicals;Chronic;Clinical;Colitis;Colon;Communities;comparative;CRISPR/Cas technology;Crohn's disease;Data;Development;dextran sulfate sodium induced colitis;Disease;disease model;disorder subtype;Distal;Doctor of Philosophy;drug development;drug discovery;Enteric Nervous System;Enterobacteria phage P1 Cre recombinase;Enteroendocrine Cell;Enzymes;Epithelium;Excision;FOLH1 gene;Foundations;Ganglia;gastrointestinal;Gastrointestinal Diseases;gastrointestinal epithelium;Gastrointestinal tract structure;Generations;Genetic;genome editing;Genomics;Germ-Free;Homeobox;Human;human disease;human model;human tissue;Ileitis;ileum;Image;Immunofluorescence Immunologic;Immunohistochemistry;improved;in vivo;Individual;Inflammation;Inflammatory Bowel Diseases;Inflammatory Infiltrate;inhibitor;insight;Interleukin-10;Knock-in Mouse;Knockout Mice;Knowledge;Lesion;LoxP-flanked allele;Medicine;Mentors;Metalloproteases;Methodology;Methods;microbiome composition;Modeling;mouse model;Mucosal Immunity;Mucous Membrane;multidisciplinary;Mus;novel;Operative Surgical Procedures;overexpression;Pathogenesis;Pathologist;Patients;Pattern;Peptide Hydrolases;Persons;Pharmacology;Phenotype;Pilot Projects;Population;pre-clinical;preclinical study;Predisposition;programs;promoter;protein expression;Public Health;Quality of life;Refractory;Reporting;Research;Research Personnel;Resistance;response;Role;Sampling;Scientist;selective expression;small molecule;Solid;Spontaneous colitis;success;Tamoxifen;Technical Expertise;Testing;Therapeutic;therapeutic target;Thick;Time;TNF gene;Training;Transgenic Organisms;Treatment Failure;trinitrobenzene sulfonic acid induced colitis;Ulcerative Colitis;United States;Up-Regulation;Veterinarians;Visceral pain;Work;Zinc

PROJECT_TITLE: Exploring Glutamate Carboxypeptidase II (GCPII) Dysregulation in Human and Experimental IBD


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Narrative Periodontal disease affects millions of individuals in the US alone and is known to greatly increase susceptibility to many other systemic diseases. Oral bacterial pathogens are clearly involved in their pathogenesis, but the role of systemic master regulators, such as microRNAs, and the innate immune pathway are not completely known. This proposal works with selected dominant microRNAs as important biomarkers in periodontal disease with the long term goal in guiding therapeutic interventions and moving toward better disease management.

PI_NAMEs: LAKSHMYYA, KESAVALU NAIDU (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: adverse pregnancy outcome;Affect;alveolar bone;Alzheimer's Disease;Autoimmune Diseases;Bacteria;Biological Assay;Biological Markers;Biology;Cardiovascular Diseases;Cells;Cellular biology;chronic inflammatory disease;Clinical;Clinical Research;clinically relevant;Complex;conventional therapy;crosslink;cytokine;Data;Dendritic Cells;Dental Cementum;Dental Plaque;Development;Disease;Disease Management;dysbiosis;Ecology;Endothelium;Endotoxins;Epithelial Cells;Epithelium;Familial Amyloid Neuropathies;Fibroblasts;Forsythia;Fusobacterium nucleatum;Future;Gene Expression;Generations;Gingiva;Gingival Crevicular Fluid;Gingival Pocket;Gingivitis;Goals;Hemophilia A;Human;Hybrids;Immune signaling;improved;In Vitro;in vivo;Individual;individual patient;Infection;Inflammation;Inflammatory;innate immune pathways;Innate Immune Response;IRAK4 gene;Journals;Kinetics;knockout gene;Knockout Mice;Laboratories;LDL Cholesterol Lipoproteins;Ligation;Lipopolysaccharides;Macrophage;Malignant Neoplasms;Maps;Maxilla;Mediating;Messenger RNA;microbial;MicroRNAs;Modeling;Molecular Biology;monocyte;mouse model;mRNA Expression;Mus;Myelogenous;Natural Immunity;neutrophil;novel therapeutics;Oral;oral cavity epithelium;Osteoblasts;Osteoclasts;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Patients;Peer Review;Peptidoglycan;Periodontal Diseases;Periodontal Ligament;Periodontitis;periodontopathogen;Play;Porphyromonas gingivalis;Predisposition;Production;Protocols documentation;Publishing;rational design;recruit;Regulation;Reporting;Resistance;response;Rheumatoid Arthritis;Role;Saliva;Series;Severity of illness;Signal Pathway;Signal Transduction;Small RNA;Spleen;Streptococcus gordonii;System;Systemic disease;Therapeutic Intervention;therapeutic miRNA;therapeutic target;therapy outcome;Time;Tissues;TLR1 gene;TLR2 gene;TLR4 gene;TNF Receptor-Associated Factors;Toll-Like Receptor Pathway;Toll-like receptors;Treponema denticola;Virus Diseases;Work

PROJECT_TITLE: Dominant microRNAs as biomarkers in innate immunity and periodontitis

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ORG_CITY: ANN ARBOR

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Metalloenzymes are the worker bees for energy generation, metabolism, signaling and pharmaceutical processing in all cells and often their misfunction can be the cause of human disease. Despite the prevalence and importance of metalloproteins, our level of understanding of the relationship between protein structure and efficient metal ion catalysis is still badly lacking. This proposal uses the innovative technique of de novo metalloprotein design to unravel the key factors that are essential to defining and controlling metal based biological catalysis, with the long term goals of understanding human disease better and providing bioinspired water soluble catalysts for chemical and pharmaceutical industries.

PI_NAMEs: PECORARO, VINCENT L (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Acidity;Acids;Active Sites;Amino Acids;aqueous;base;Bees;Behavior;Binding;Binding Proteins;Binding Sites;Biological;carbonate dehydratase;Catalysis;catalyst;Cells;Chemical Industry;Chemicals;Chemistry;cold temperature;Collaborations;Complex;Creativeness;Cytoskeletal Proteins;design;DNA Insertion Elements;Drug Industry;Environment;enzyme activity;Evaluation;Foundations;Generations;Geometry;Goals;Heavy Metals;Human;human disease;innovation;insight;Ions;Kinetics;Ligands;Ligation;Metabolism;metalloenzyme;Metalloproteins;Metals;Modeling;Modification;Molecular;Molecular Weight;Nature;Nitrites;non-Native;novel strategies;Organism;Oxidation-Reduction;Peptides;Pharmacologic Substance;Preparation;Prevalence;Process;Production;Protein Engineering;protein folding;protein function;protein structure;Proteins;Published Comment;Reaction;Research;Resolution;Retrotransposon;scaffold;Scaffolding Protein;Scientist;screening;Side;Signal Transduction;Site;small molecule;Solvents;structural determinants;Structure;System;Techniques;Testing;Thermodynamics;three dimensional structure;Time;Transition Elements;Untranslated RNA;Water;water channel;Work;Zinc

PROJECT_TITLE: Designing Functional Metalloproteins

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_NAME: DURHAM VA MEDICAL CENTER

PHR: The purpose of this award is to support the research, training and service activities of Dr. Courtney Van Houtven, who is an experienced Department of Veterans Affairs investigator. Dr. Van Houtven leads research studies that test care models to improve the function and independence of older adults with functional limitations and the function of their informal caregivers. The overarching goal of her research agenda is to enable at-risk Veterans to remain at home as safely as possible and for as long as possible. This research is important because there are 9.8 million Veterans over age 65 and 5.5 million Veterans receive informal care in order to remain at home. Dr. Van Houtven’s research will continue to study how we can best provide care for Veterans at risk of permanent nursing home entry, including the best means of supporting their caregivers.

PI_NAMEs: VAN HOUTVEN, COURTNEY HAROLD (contact)

PROJECT_TERMS: Affect;Age;Award;Budgets;career;Caregiver support;Caregivers;Caring;Clinical;Clinical Trials;community based service;Community Healthcare;Congresses;cost;Counseling;Dedications;design;disability;economic evaluation;Economics;effectiveness testing;Engineering;Evaluation;Expenditure;experience;Face;Faculty;Family member;Feedback;Financial Hardship;Financial Support;Friends;Functional impairment;functional improvement;Funding;Geriatrics;Goals;Grant;Grant Review;Health;health care service utilization;health economics;health equity;Health Services Research;Healthcare Systems;Hexachlorobenzene;Home;Home Nursing Care;human old age (65+);implementation evaluation;implementation science;implementation study;improved;indexing;informal care;informal caregiver;informal caregiving;International;Intervention;Journals;K-Series Research Career Programs;Leadership;lens;London;Measurement;Measures;Medicine;Mentors;Mentorship;Methods;Mission;Modeling;next generation;Nursing Homes;older adult;Patients;Performance;person centered;Policies;Policy Analysis;post 9/11;Program Evaluation;programs;Publications;Publishing;Quality of life;Randomized;recruit;Research;Research Activity;Research Personnel;research study;Research Support;Risk;Schools;Science;Scientist;service engagement;Services;Site;skills;skills training;Strategic Planning;Structure;Testing;Time;Training;Training Programs;United States Department of Veterans Affairs;United States National Academy of Sciences;United States National Institutes of Health;Veterans;Work

PROJECT_TITLE: HSR&D Merit Review Research Career Scientist Award

STUDY_SECTION_NAME: HSR-7 Capacity Building[HSR7]


PHR: Posttraumatic stress disorder (PTSD) is prevalent among Veterans and effective evidence-based psychotherapies (EBPs) for PTSD have been implemented within the Veterans Health Administration (VHA). However, retention in PTSD EBPs is poor. Premature dropout is associated with worse clinical outcomes and greater healthcare utilization. Delivery of PTSD EBPs in a massed format, typically three or more days per week delivered within a month, have shown promise for increasing retention. This CDA-2 proposal is highly relevant because PTSD is a VA and HSR&D priority. Additionally, if effective, massed treatment delivery would offer another option for Veterans to access PTSD treatment, which would increase patient-centered care. Increased retention in PTSD EBPs would also better utilize provider and system resources by increasing the number of Veterans who receive an adequate dose of a PTSD EBP.

PI_NAMEs: WELLS, STEPHANIE  (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Administrator;Adoption;Caring;Clinic;Clinical;Clinical Trials Design;Cognitive;cohort;comparison group;Competence;Consolidated Framework for Implementation Research;Data;data warehouse;design;Development;Distress;Dose;Dropout;Drops;Effectiveness;effectiveness/implementation trial;Evaluation;evidence base;experience;Feedback;Frequencies;Future;health care service utilization;Hybrids;implementation facilitators;implementation science;improved;innovation;Intervention;Interview;Letters;medical specialties;Mental Depression;Mentors;Methodology;Methods;Modification;Outcome;Outpatients;Patient-Centered Care;Patients;pilot trial;Post-Traumatic Stress Disorders;preference;premature;programs;Provider;Psychotherapy;Quality of life;randomized, clinical trials;reduce symptoms;Reporting;Research;Research Design;Resource Allocation;Resources;satisfaction;Schedule;Signal Transduction;social cognitive theory;Structure;Symptoms;System;systematic review;tau Proteins;Testing;Time;Training;Trauma;treatment as usual;treatment comparison;treatment optimization;treatment program;treatment response;Uncontrolled Study;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Adapting Treatment Delivery to Improve Retention in Evidence-Based PTSD Treatment

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


FUNDING_MECHANISM: RESEARCH CENTERS

PHR: Seriously-ill veterans rely on spiritual and existential beliefs to cope with their illness, support their quality of life, and make critical decisions about their care. VHA Directive 1111mandates that assessment must identify the importance of spirituality and religion for the patient, how it affects care, and comprehensive follow up, when needed. To assist in compliance with this mandate our research team developed and validated the first quantifiable spiritual screening tool (VET-Spirit) designed specifically for seriously-ill veterans. It offers the means to identify needs, resources and the impact of beliefs on care and decision-making. The proposed study develops and evaluates the feasibility and acceptability of integrating VET-Spirit into care. While our ultimate goal is to improve unmet veteran spiritual needs, this proposal focuses on provider outcomes (physicians and advanced practice providers) of those with advanced serious illness.

PI_NAMEs: STEINHAUSER, KAREN E (contact)

PROJECT_TERMS: acceptability and feasibility;Accountability;Address;Affect;Agreement;Belief;Cardiology;care coordination;care delivery;care preference;Caring;Chaplain;Chronic Obstructive Pulmonary Disease;Clinical;clinical care;clinical practice;Communication;Complex;Congestive Heart Failure;coping;Data;Decision Making;design;Development;effectiveness/implementation trial;Eligibility Determination;end of life;Enrollment;Ensure;Evaluation;experience;Family member;Focus Groups;follow-up;Frequencies;Funding;Future;Goals;Health Care Costs;health care service organization;Health Personnel;Healthcare;Hybrids;implementation measures;implementation strategy;improved;innovation;Intervention;Interview;Knowledge;Life;Link;Location;Malignant Neoplasms;Measures;Medical;member;Mental Health;Methodology;Methods;Modeling;Motivation;Oncology;Outcome;Pain management;palliative;Palliative Care;Participant;Patient Care;patient response;Patient-Centered Care;Patients;Personal Satisfaction;physical symptom;Physicians;pilot test;preference;Process;Provider;provider communication;Psychometrics;Qualitative Methods;Quality of life;Religion and Spirituality;Reporting;Research;Research Personnel;Resources;response;Sampling;satisfaction;screening;Screening procedure;Self Efficacy;Spiritual care;Spiritual well-being;Spirituality;statistics;Stream;symptom management;tool;trend;Validation;Veterans;Visit;Voice;Work

PROJECT_TITLE: VET-Spirit: A Pilot Feasibility and Acceptability Trial to Address Spiritual Needs in Seriously-Ill Veterans

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Chemoenzymatic synthesis of bacterial nonulosonic acids and glycans The efficient chemoenzymatic methods developed in this proposal will allow the access of bacterial nonulosonic acids and glycans which are virulence factors of pathogenic bacteria. The glycans produced can be anti-bacteria vaccine candidates and essential probes to identify the corresponding antibodies and protein binders. Information will also be learned regarding biosynthesis of these important bacterial virulence factors and facilitate in the future development of inhibitors as potential antibiotics.

PI_NAMEs: CHEN, XI  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Narrative: In order to gain insight into the mechanistic underpinnings of diseases at a molecular level, deciphering structure/function relationships of biological molecules encompasses one of the key objectives of biomedical research. The compelling need for greater chemical insight has motivated my group’s effort to develop innovative mass spectrometry methods to characterize structures of biological molecules, particularly lipids, proteins, and macromolecular assemblies, in unprecedented detail.

PI_NAMEs: BRODBELT, JENNIFER S. (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Antibiotic Resistance;Area;Binding;Biological;Biomedical Research;C-terminal;Capillary Electrophoresis;Cellular Membrane;Chemicals;Collaborations;Complex;design;Disease;frontier;functional outcomes;Genetic Transcription;Goals;Hybrids;Individual;innovation;insight;Ligands;Lipids;macromolecular assembly;Mass Spectrum Analysis;Membrane Proteins;Methods;Microbiology;Modification;Molecular;Molecular Biology;novel therapeutics;Nucleic Acids;oxidation;pathogenic bacteria;Pattern;Phosphorylation;Post-Translational Protein Processing;programs;protein complex;protein function;Proteins;Research;RNA Polymerase II;Structure;tandem mass spectrometry;Technology;ultraviolet

PROJECT_TITLE: Ultraviolet Photodissociation Mass Spectrometry for Characterization of Biological Molecules

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


ORG_CITY: SEATTLE

ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

ORG_STATE: WA

PHR: PROJECT NARRATIVE. Over 100 million Americans and approximately 50% of U.S. military Veterans suffer from chronic pain. Research indicates a strong, bidirectional link between chronic pain conditions and internalizing psychiatric disorders and individuals with both chronic pain conditions and internalizing disorders show worse treatment prognosis, increased impairment, and greater use of opioid medication. While the association between chronic pain and internalizing disorders is well documented, the underlying mechanisms that drive the association remain elusive. This CDA-2 project will use electronic health record and genetic data from the Million Veterans Program to identify the genetic factors common to the development of these conditions and sets the stage for progression from genetic epidemiology to precision medicine. Improved understanding of the mechanism underlying this relationship can reduce negative consequences such as opiate use, healthcare costs and societal burden, and improve access to care for Veterans.

PI_NAMEs: GASPERI, MARIANNA  (contact)

PROJECT_TERMS: Address;Algorithms;American;Anxiety Disorders;Attention;Biometry;Chromosome Mapping;Chronic Fatigue Syndrome;chronic pain;chronic painful condition;Clinical Data;Clinical Research;comorbidity;cost;Data;design;Development;Diagnosis;Disease;Economics;Electronic Health Record;epidemiology study;Etiology;Evaluation;Fibromyalgia;Genes;Genetic;Genetic Determinism;genetic epidemiology;Genetic Models;Genetic Predisposition to Disease;genetic variant;genome wide association study;genome-wide;Goals;Grant;Health Care Costs;Health Services Accessibility;Heritability;Impairment;Improve Access;improved;Individual;Intervention;Investigation;Irritable Bowel Syndrome;Knowledge;Link;Linkage Disequilibrium;Literature;Maps;Mediating;Mendelian randomization;Mental Depression;Mental disorders;Mentors;Methodology;Methods;Migraine;military veteran;Modeling;Molecular Genetics;Mood Disorders;novel;observational cohort study;opioid epidemic;opioid use;Pain;Pain intensity;personalized medicine;Phenotype;Post-Traumatic Stress Disorders;precision medicine;prescription opioid;Prognosis;programs;Psychopathology;Public Health;Quality of life;Quantitative Genetics;Reading;Research;research and development;Research Ethics;Research Personnel;research study;Resources;Risk;risk sharing;Role;Sample Size;Sampling;Series;Severities;sex;sex variable;Single Nucleotide Polymorphism;skills;social;Susceptibility Gene;symposium;Temporomandibular Joint Disorders;Tension Headache;Testing;Therapeutic Intervention;Training;trait;Translational Research;Treatment outcome;Twin Multiple Birth;Twin Studies;United States Department of Veterans Affairs;Veterans;Writing

PROJECT_TITLE: Chronic pain conditions and internalizing psychopathology, a genetic epidemiology investigation.


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Narrative Visual object motion often guides the movements of humans and insects alike. However, sensorimotor integration is a computationally challenging task, as it requires the brain to transform its representation of space from visual-centric coordinates to body-centric coordinates. My work aims to shed light on this fundamental mechanism by studying a neural network in the fruit fly Drosophila melanogaster that is well-positioned to perform such an inference during object chasing behavior.

PI_NAMEs: COLLIE, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TITLE: Visuomotor Coordinate Transformation During Drosophila Chasing Behavior


ADMINISTERING_IC: MD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Lung;Lung Cancer;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE Lung cancer is the leading cause of cancer-related death across all major populations in the U.S.; however, risk of lung cancer is not the same across racial/ethnic groups. To better understand the underlying mechanisms contributing to lung cancer racial/ethnic disparities, we will conduct a molecular profiling study of lung adenocarcinoma tissue from five major racial/ethnic groups. Our findings will help identify personalized treatment targets and strategies to mitigate these disparities.

PI_NAMEs: LOO, LENORA WM;PARK, SUNGSHIM LANI (contact)

PROGRAM_OFFICER_NAME: MARTIN, IMAN

PROJECT_TERMS: Accounting;actionable mutation;Adenocarcinoma;African American;African American population;Age;Asian population;Biological;Biological Markers;Biology;Cancer Etiology;cancer risk;cancer survival;Carcinogens;cell type;Cessation of life;Cigarette;Cohort Studies;Data;Development;Diagnosis;Disease;disorder risk;Disparate;Disparity;Disparity population;disparity reduction;DNA;DNA analysis;DNA Integration;DNA Methylation;Dose;Epidermal Growth Factor Receptor;epigenome-wide association studies;ethnic difference;ethnic disparity;Ethnic Origin;Ethnic Population;Follow-Up Studies;Frequencies;Gene Expression;Gene Expression Profile;genome-wide;Germ Lines;Goals;Health behavior;Heterogeneity;high risk;Histologic;improved;Incidence;Invaded;Japanese American;Latino;Latino Population;Leukocytes;Life Style;Lung Adenocarcinoma;lung cancer cell;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Mediating;men;Methylation;Minority Groups;Modeling;Modification;Molecular;Molecular Profiling;multi-ethnic;multidisciplinary;Native Hawaiian;Nicotine;novel;Pathway interactions;personalized medicine;Population;Proliferating;prospective;Race;racial difference;racial disparity;racial population;Reporting;Research Design;Resources;Risk;Risk Factors;Sampling;sex;Signal Pathway;Smoker;Smoking;Smoking History;smoking prevalence;Smoking Status;stem cells;Subgroup;targeted treatment;Testing;Tissues;Tobacco smoking behavior;transcriptome;transcriptomics;tumor;tumor behavior;Tumor Biology;Tumor stage;Tumor Tissue;United States;urinary;Woman

PROJECT_TITLE: Comprehensive molecular characterization of lung cancers in five racial/ethnic groups with disparate risk

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-A(55)R]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Disparities in cardiovascular diseases (CVD) abound. There is growing evidence that social determinants of health across several domains and levels of influence over the life course can play a role in producing such disparities in CVD. We propose to apply several analytic approaches including key informant interviews, the synthetic control method and systems science to evaluate the impact and costs of intervention strategies that have the potential to efficiently reduce CVD health disparities.

PI_NAMEs: NIANOGO, ROCH  (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: African American population;Age;Alaska Native;American Indians;Behavioral;Biological Models;Birth;California;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cause of Death;Cessation of life;Cigarette;cohort;Communities;Computer Simulation;Computing Methodologies;Coronary heart disease;cost;cost effective;cost effectiveness;Cost of Illness;Cost Savings;Costs and Benefits;Data;Decision Making;design;Diabetes Mellitus;Disadvantaged;Disease;disease disparity;Disparity;Disparity population;disparity reduction;Economically Deprived Population;Economics;Effectiveness of Interventions;Environment;Epidemiology;Equilibrium;Evaluation;experience;Failure;Focus Groups;Funding;Future;General Population;Health;health disparity;Healthcare;Heart Diseases;high risk;High-Income Populations;Hypertension;Incidence;Individual;informant;innovation;Intervention;intervention cost;Intervention Studies;Interview;Knowledge;large scale data;Life Cycle Stages;Los Angeles;Low income;Medical;Mentorship;Methods;models and simulation;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Patients;Persons;Physical environment;Physicians;Policies;Policy Maker;Population;population health;Populations at Risk;Prevalence Study;prevent;Prevention;Public Health;public health intervention;Quasi-experiment;racial population;Randomized, Controlled Trials;Reduce health disparities;Research;Research Personnel;Review Literature;Risk;Risk Factors;Sampling;Science;Secure;skills;social determinants;social disparities;social factors;social health determinants;soda tax;Sodium Chloride;Stroke;success;System;systematic review;Taxes;Testing;therapy design;Unhealthy Diet;virtual;Vulnerable Populations;Work

PROJECT_TITLE: The SMART-CV Study: Systems Modeling Approaches to Reducing Disparities in Cardiovascular Diseases


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Neurosciences

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE The primary goal of this proposal is to identify the activity-dependent mechanisms mediating memory formation in the CA3 region of the hippocampus. Learning and memory is driven by activity-induced changes in neurons and circuits, and the CA3 region of the hippocampus is particularly important in linking sensory experiences to the context in which they occur. Understanding how CA3 neurons change during the formation of a contextual memory will provide us with valuable foundational knowledge of proper cognitive function, and will allow us to further investigate cases of cognitive disorders.

PI_NAMEs: RAMOS, CZARINA  (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: activity marker;Affect;Area;Behavior;behavioral outcome;Biological;Brain;Brain region;Cells;Characteristics;Cognition Disorders;cognitive function;cognitive process;conditional knockout;conditioned fear;Cues;Data;dentate gyrus;Detection;Electrophysiology (science);entorhinal cortex;environmental enrichment for laboratory animals;Epilepsy;Equilibrium;Event;excitatory neuron;Exhibits;experience;experimental study;Foundations;Gene Expression;genetic approach;Goals;granule cell;hippocampal pyramidal neuron;Hippocampus;Immediate-Early Genes;Impairment;Knowledge;learned behavior;Learning;Link;Mediating;Memory;memory encoding;memory recall;memory retrieval;Modification;Molecular;Morphology;mossy fiber;Nature;neuronal circuitry;Neurons;NPAS4 gene;Output;Pathway interactions;Perforant Pathway;Play;Population;Process;programs;Property;recruit;Recurrence;response;Retrieval;Role;Sensory;sensory cortex;Specificity;Stimulus;Structure;superresolution microscopy;Surveys;Synapses;Synaptic Transmission;synaptogenesis;System;Testing;transcription factor;transmission process;Weight;Work

PROJECT_TITLE: Activity Dependent Changes in the Contextual Memory Engram


NIH_SPENDING_CATS: American Indian or Alaska Native;Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Precision Medicine;Racial and Ethnic Minority Health Research

PHR: NARRATIVE Chronic Kidney Disease is a global health epidemic and is associated with increased mortality, but we do not have a detailed understanding of why this disease progresses. Identifying sub-types of patients who progress by the same molecular mechanism is important to identify patients for future clinical trials. This project aims to use gene expression data from kidney biopsies to identify patients who will respond differently to medications that increase the expression of Hypoxia Inducible Factor-1 alpha.

PI_NAMEs: SCHAUB, JENNIFER ANN (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Address;Anemia;Animals;Atherosclerosis;Atrophic;Award;Beds;biobank;Bioinformatics;Biological Markers;Biology;biomarker identification;Biopsy;Cardiovascular Diseases;cell type;Cells;Chronic;Chronic Kidney Failure;Clinical;Clinical Data;clinical phenotype;Clinical Treatment;Clinical Trials;cohort;Complex;Data;Data Set;Descriptor;Disease;Disease Progression;End stage renal failure;Epidemic;Erythropoietin;experience;Fibrosis;Future;Gene Expression;Gene Expression Profile;Gene Expression Profiling;global health;Glomerular Filtration Rate;glomerulosclerosis;Goals;Hypoxia;Hypoxia Inducible Factor;hypoxia inducible factor 1;improved;improved outcome;individualized medicine;inhibitor;Injury;interstitial;Investigation;Kidney;kidney biopsy;Machine Learning;Measures;Mentors;Molecular;Molecular Profiling;Monitor;Morphology;mortality;mortality risk;Native Americans;Nephrology;Nephrotic Syndrome;Non-Insulin-Dependent Diabetes Mellitus;novel;novel marker;novel therapeutics;Outcome;Pathologic;Pathology;Pathway interactions;patient stratification;patient subsets;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;phase III trial;Pima Indian;predictive marker;Process;Procollagen-Proline Dioxygenase;Production;Renal function;Reproducibility;research clinical testing;Resources;response;Sampling;Serum;Severities;Severity of illness;single-cell RNA sequencing;Specificity;statistical and machine learning;Statistical Models;Systems Biology;Techniques;Testing;Therapeutic;Therapeutic Agents;Therapeutic Intervention;Tissues;Training;transcription factor;Tubular formation;Urine

PROJECT_TITLE: A Systems Biology and Patient Stratification Approach to Improve Outcomes of Patients with Hypoxic Injury in Renal Tubular Cells in Chronic Kidney Diseases

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: SANTA BARBARA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: Narrative The U.S. is in the midst of a psychostimulant epidemic. Drug-craving is a diagnostic criterion of Psychostimulant Use Disorder for which there exists no clinically effective intervention. This project examines disrupted glutamate- dopamine interactions within prefrontal cortex as a core neuropathology driving drug-craving.

PI_NAMEs: SZUMLINSKI, KAREN KATHLEEN (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Abstinence;addiction;Address;AMPA Receptors;Animal Experimentation;Animal Model;Animals;antagonist;Automobile Driving;base;Behavior;Behavioral;biobehavior;Biochemical;Biochemistry;Biological Assay;Brain region;Chronic;Clinical;Cocaine;cocaine craving;cocaine exposure;cocaine seeking;Cognitive;craving;Cues;Data;diagnostic criteria;Disease;Disease Management;disease model;Dopamine;Dopamine D1 Receptor;Dopamine Receptor;Down-Regulation;drug craving;drug seeking behavior;effective intervention;Epidemic;Exhibits;experience;Experimental Designs;Extinction;extracellular;gamma-Aminobutyric Acid;Glutamate Receptor;Glutamates;GRM1 gene;GRM5 gene;Human;Hyperactivity;Impaired cognition;in vivo;Incubated;innovation;insight;Intake;kainate;Laboratory Animals;Learning;Link;Mediating;Mediator;Metabolic;Metabotropic Glutamate Receptors;Methamphetamine;Microdialysis;Modeling;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;Nature;Neurobiology;neurochemistry;neuropathology;Neurotransmitters;non-drug;novel;Pathologic;Pathology;Patients;Pharmaceutical Preparations;pharmacologic;postsynaptic;pre-clinical;Predisposition;Prefrontal Cortex;Process;Psychological reinforcement;psychostimulant;Rattus;receptor;receptor function;Recording of previous events;Regulation;reinforcer;Relapse;Reporting;Research;Role;Scaffolding Protein;Series;Signal Transduction;Specificity;Stimulant;stimulant use disorder;Sucrose;Testing;theories;Therapeutic;Time;transmission process;Treatment Efficacy;treatment strategy;Withdrawal;Work

PROJECT_TITLE: Incubated drug-craving and neurochemical interactions

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Relevance  Dioxygen binding and activation by metalloproteins are processes that are directly  linked to the maintenance of human health and aging. The protein-induced  microenvironments surrounding the active metal center(s) are instrumental in  regulating these functions, and the function and dysfunction of health-related  metalloproteins can therefore be understood in the context of changes in their  microenvironments. Non-covalent interactions, including hydrogen bonds, are  acknowledged as the major forces that control microenvironmental effects, but it is still  unclear how they are able to influence metal-mediated processes. Thus, understanding  the influence of these effects requires fundamental reactivity and mechanistic studies in  which the contributions of single components can be analyzed individually, as described  in this research.

PI_NAMEs: BOROVIK, ANDREW S. (contact)

PROJECT_TITLE: Hydrogen Bonding Cavity Motifs About Metal Ions

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Project Narrative A somatic GEMM of TNBC driven by a p53 missense mutation shows mutant p53 deletion causes tumor regression and an infiltration of T lymphocytes. This study aims to understand how mutant p53 tumors evolve, the downstream pathways that contribute to addiction, and the contributions of the immune microenvironment.

PI_NAMEs: LOZANO, GUILLERMINA  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: addiction;Alleles;Apoptosis;Biology;BRCA1 gene;Breast;cancer care;Cancer cell line;cancer initiation;Cell Culture Techniques;Cell Cycle Arrest;Cell Line;Cells;Collection;Complex;CRISPR/Cas technology;Defect;Development;Disease;DNA Binding;driver mutation;Exhibits;exome;experimental study;Frequencies;functional genomics;gain of function;GATA3 gene;Gene Expression;Genes;Genetic Transcription;Genetically Engineered Mouse;genomic profiling;Growth;Histology;Human;Human Genetics;Immune;Immune response;Immune system;Immunotherapy;in vivo;Incidence;Infiltration;Knock-in Mouse;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;mammary epithelium;Mammary Neoplasms;Metabolism;Missense Mutation;Modeling;Molecular;molecular pathology;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;neoplastic cell;novel;Pathway interactions;Pharmaceutical Preparations;Phenotype;PIK3CA gene;Positioning Attribute;pre-clinical;Preclinical Testing;programs;Proteins;PTEN gene;Recurrence;response;Role;senescence;Sequence Analysis;T-Lymphocyte;Testing;Therapeutic;tool;TP53 gene;transcription factor;Transcriptional Activation Domain;transcriptome sequencing;triple-negative invasive breast carcinoma;tumor;tumor microenvironment;Tumor Suppressor Genes;Tumor Suppressor Proteins;tumor-immune system interactions;tumorigenesis;Women's mortality;Work

PROJECT_TITLE: Role of p53 Missense Mutations on Tumorigenesis in Vivo

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Clinical Research;Disability Research;Immunization;Multiple Sclerosis;Neurodegenerative;Neurosciences;Prevention;Vaccine Related

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE Multiple sclerosis (MS) is a chronic, inflammatory disease of the central nervous system that produces disabil- ity through immune-mediated demyelination and subsequent neuro-axonal injury. Neuroprotective therapies that prevent neuro-axonal loss independent of peripheral immune effects are a major goal of current research, both to complement current therapies and to slow disability in the progressive phase of MS, which is no longer driven by peripheral immune activation. This proposal evaluates a candidate signaling pathway that may pro- mote neuro-axonal injury in neuroinflammation, while establishing the pre-clinical potential of a brain-penetrant drug that selectively blocks this pathway.

PI_NAMEs: KORNBERG, MICHAEL D (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Active Immunization;Adaptive Immune System;adaptive immunity;Address;Area;Attenuated;Autopsy;Biochemical;Bioenergetics;Biogenesis;Biological Assay;Biology;Biotin;Brain;brain tissue;C57BL/6 Mouse;career development;Cell Death;Cell Nucleus;cell type;Central Nervous System;Central Nervous System Diseases;central nervous system injury;Chronic;Clinical;clinical translation;Complement;Data;Demyelinating Diseases;Demyelinations;Development Plans;disability;Disease;Experimental Autoimmune Encephalomyelitis;experimental study;Exposure to;Flow Cytometry;Foundations;Free Radicals;Future;Genetic;Goals;Histopathology;Human;Immune;immune activation;immune cell infiltrate;Immune response;Immune system;Immunization;Immunology;Impairment;Inflammation;Inflammatory;Injury;insight;Lymphoid Cell;Macrophage;Measures;Mediating;Mentors;Mentorship;Methods;Microglia;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Modeling;Molecular;mouse model;Multiple Sclerosis;multiple sclerosis patient;Myelogenous;Nerve Degeneration;Neuroglia;neuroimmunology;neuroinflammation;Neurologic Deficit;Neurological disability;Neurons;neuroprotection;Neuroprotective Agents;Nitric Oxide;novel;novel therapeutic intervention;Nuclear;Optic Nerve;Oral;Pathologic;Pathway interactions;Peripheral;Pharmaceutical Preparations;pharmacologic;Phase;Play;Post-Translational Protein Processing;pre-clinical;preclinical study;prevent;Prevention;Progressive Disease;protective effect;Proteins;Relapse;Research;Respiration;Retina;Role;Safety;Signal Pathway;Signal Transduction;SIRT1 gene;Spinal Cord;System;Techniques;Therapeutic;Therapeutic Research;Tissues;tool;training opportunity;white matter;Work

PROJECT_TITLE: Targeting SNO-GAPDH in inflammatory neurodegeneration and mitochondrial injury

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Microbiome;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE This proposal offers an unparalleled opportunity to characterize the biological impact of aspirin, perhaps the most promising widely available chemopreventive agent, and the gut microbiome on the normal colon by leveraging the uniquely valuable resources of a randomized clinical trial. To accomplish this objective, we will advance novel patient-derived modeling systems to rigorously investigate putative chemopreventive mechanisms and refine causal relationships between aspirin, the gut microbiome, and intestinal epithelial cells. Ultimately, this work may lead to novel chemoprevention targets and the development of precision prevention strategies for chronic digestive diseases.

PI_NAMEs: DREW, DAVID A (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: 3-Dimensional;Address;adenoma;Agonist;antagonist;ApcMin/+ mice;Area;Aspirin;AXIN2 protein;Basic Science;beta catenin;Bile Acids;Bioinformatics;Biological;Biological Models;Biopsy;cardiovascular disorder prevention;cardiovascular disorder risk;Cells;Chemopreventive Agent;Chronic;Clinic;Clinical;Collecting Cell;Colon;colon microbiome;Colorectal;Colorectal Adenoma;Colorectal Cancer;colorectal cancer progression;Colorectal Neoplasms;Data;Development;Digestive System Disorders;Dinoprostone;Disease;Dose;double-blind placebo controlled trial;Epithelial Cells;Epithelium;Equilibrium;experience;Feces;Funding;Fusobacterium nucleatum;Gastroenterology;Gastrointestinal tract structure;Gene Expression;Generations;Genomics;Glycochenodeoxycholate;Goals;gut homeostasis;gut microbiome;Gut Mucosa;Health;Health Benefit;Human;Immune;In Vitro;Individual;individualized prevention;Inflammation;Inflammatory;injury and repair;Intervention;intestinal epithelium;Intestines;Joints;Laboratories;Link;Measures;Mediating;Metabolic;metabolomics;Metagenomics;metatranscriptomics;Methodology;microbial;microbiome;microbiota;Mission;Modeling;mouse model;Mucous Membrane;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Natural regeneration;Neoplasms;neoplastic;novel;novel chemoprevention;Organoids;Pathway interactions;Patients;Placebos;Plasma;Postdoctoral Fellow;pre-doctoral;Prevention strategy;Primary Prevention;Prospective Studies;Prostaglandin Inhibition;Prostaglandin-Endoperoxide Synthase;Prostaglandins;Randomized;randomized, clinical trials;receptor;Recommendation;Recording of previous events;Research Personnel;Resources;Risk;Role;Shotguns;Signal Transduction;skills;Sorting;stem cell division;stem cell homeostasis;stem cell proliferation;stem cells;stool sample;Supplementation;synergism;Taurodeoxycholate;Tissues;Training;transcriptome sequencing;translational scientist;Tumor Burden;tumorigenesis;tumorigenic;United States Preventative Services Task Force;Work

PROJECT_TITLE: Impact of Aspirin on the Gut Microbiome and Mucosal Microenvironment

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ORG_CITY: TUCSON

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because fibrosis (the scarring of injured tissue) plays a major role in the development and progression of heart disease – the leading cause of death among Americans. The proposed studies will provide a greater understanding of the cells that cause and regulate fibrosis processes in the heart. Thus, the proposed research is relevant to the part of NHLBI's mission that pertains to developing new treatment strategies to protect the heart and slow or prevent progression to heart failure – a condition that affects 5.2 million Americans.

PI_NAMEs: HALE, TABEN M. (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Affect;Aftercare;American;Angiotensin II;Area;Automobile Driving;blood pressure reduction;Cardiac;Cause of Death;Cells;Cellular Assay;Chromatin;chromatin remodeling;Chromatin Structure;Cicatrix;coronary fibrosis;Data;Development;Ensure;Enzyme Inhibition;Epigenetic Process;Exhibits;experimental study;Extracellular Matrix;fascinate;Fibroblasts;Fibrosis;Future;Gene Expression;Genes;HDAC2 gene;Heart;Heart Diseases;Heart failure;Histone Deacetylase;Hypertension;hypertensive;In Vitro;in vivo;Inbred SHR Rats;Infusion procedures;injured;interdisciplinary approach;Knockout Mice;Laboratory Finding;Left;Left ventricular structure;Mediating;Memory;Methodology;Mission;Modification;Myofibroblast;National Heart, Lung, and Blood Institute;novel therapeutic intervention;osteopontin;Patients;Peptidyl-Dipeptidase A;Phenotype;Physiological;Physiology;Play;Population;pressure;prevent;Prevention;Process;Production;programs;Proliferating;Protein Isoforms;Proteins;Public Health;Rattus;Research;Resistance;response;Risk Factors;Role;Signal Transduction;single-cell RNA sequencing;Small Interfering RNA;targeted treatment;Testing;Tissues;tool;Transcript;Transposase;Validation;Ventricular;Work

PROJECT_TITLE: Targeting Resident Cardiac Fibroblast Subpopulations for Protection Against Fibrosis

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: CHAMPAIGN

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: PROJECT NARRATIVE: Many disorders, such as dyslexia and autism, involve the inability to switch between hearing and other senses. We will investigate a brain structure that is potentially involved in this process: the thalamic reticular nucleus. By using a combination of modern approaches, we will characterize this pathway to shed light on how it may become dysfunctional during these disease states.

PI_NAMEs: LLANO, DANIEL A (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustics;Anatomy;Area;Attention;Auditory;Auditory area;Auditory system;auditory thalamus;autism spectrum disorder;awake;Binding;Brain;calcium indicator;Cell Nucleus;Cells;Characteristics;Chemical Synapse;cognitive change;Communication;Communication impairment;computer studies;Data;Disease;Dorsal;Dyslexia;Electrical Synapse;Electrophysiology (science);Environment;Failure;Genetic;genetic manipulation;Goals;Hearing;Heart;Image;imaging approach;In Vitro;in vivo;inducible Cre;Lasers;lens cortex;Link;Maps;Measures;Medial;Medial geniculate body;Mediating;Modality;Modeling;Modernization;multimodality;multisensory;Mus;network architecture;Neurons;novel;optical imaging;Optics;Pathway interactions;pharmacologic;Physiological;Population;Preparation;Process;Property;Rabies;Resources;response;Role;Scanning;segregation;Sensory;sensory processing disorder;sensory stimulus;sensory system;Signal Transduction;Slice;somatosensory;Stimulus;Stream;Structure;Synapses;System;Testing;Thalamic Nuclei;Thalamic structure;Thinness;Travel;Virus;Visual;Work

PROJECT_TITLE: Synaptic mechanisms of auditory thalamic cross-modal communication

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative DNA recombination is essential for chromosome stability, for antibody diversification, for gene targeting that has broad application in the medical field, and is highly relevant to many human disorders, cancer, and aging. This project will address fundamental questions about the mechanism and control of recombination, focusing on the formation of the initial recombination intermediate, single-stranded DNA.

PI_NAMEs: IRA, GRZEGORZ A (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Acetylation;Address;Aging;Antibodies;Applications Grants;Biological Assay;Cell Cycle;Cells;Centromere;Chromatin;Chromosomal Breaks;Chromosomal Stability;Complex;Data;Defect;design;Disease;DNA;DNA biosynthesis;DNA Double Strand Break;Double Strand Break Repair;Euchromatin;Excision;experimental study;Fission Yeast;Future;Gene Conversion;Gene Targeting;genetic information;Genetic Recombination;Genetic Transcription;Genome;Genome Stability;Genomics;Goals;helicase;Heterochromatin;Histone Deacetylase;homologous recombination;Human;human disease;interest;Invaded;Investigation;Laboratories;Malignant Neoplasms;Mediating;Medical;Minor;model organism;mutant;Mutation;Nonhomologous DNA End Joining;nuclease;Pathway interactions;permissiveness;Play;Positioning Attribute;prevent;Process;Proteins;RAD52 gene;Regulation;Regulatory Pathway;repaired;Repetitive Sequence;Resected;response;restraint;Retrotransposon;Role;Saccharomycetales;Single-Stranded DNA;Site;System;telomere;Testing;Work;yeast genome;Yeast Model System;Yeasts

PROJECT_TITLE: Regulation of Initial Steps of Chromosomal Breaks Repair

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

PHR: Project Narrative Zinc is an essential micronutrient and misregulation of zinc is a central feature of many human diseases. The proposed research will elucidate the fundamental mechanisms by which zinc regulates cell signaling and controls cell physiology. The proposed work will also develop a suite of tools for tagging and tracking individual RNA molecules in live mammalian cells to visualize and quantify dynamics, localization, and function.

PI_NAMEs: PALMER, AMY E (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Address;Apoptosis;Benchmarking;Binding;Biochemistry;Biological Assay;Biology;Biophysics;Cell Cycle;Cell Physiology;Cell Proliferation;Cells;Cellular biology;Chemicals;Complex;Development;Disease;DNA Binding;DNA biosynthesis;Fluorescent Probes;fluorophore;Genetic Transcription;Genomics;Growth;Health;Human;human disease;Human Genome;immune function;improved;Individual;Ions;Iron;live cell imaging;Mammalian Cell;Mammals;Maps;Measurement;Mediating;Metals;Micronutrients;mRNA tagging;Organism;Pathway interactions;Performance;Physiological;programs;Proteins;Proteome;Proteomics;Regulation;Research;RNA;Series;Signal Transduction;Suggestion;Technology;Titrations;tool;tool development;transcription factor;Transition Elements;Visualization;Work;Zinc

PROJECT_TITLE: lluminating the biochemistry of zinc and RNA in live cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Cancer;Cerebrovascular;Genetic Testing;Genetics;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PI_NAMEs: BECK, DAVID  (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Adrenal Cortex Hormones;Adult;Affect;Appearance;Arthralgia;autoinflammatory;Caring;Cell Culture Techniques;Cell Survival;Cells;Characteristics;Clinical;clinical care;clinical phenotype;Codon Nucleotides;cohort;cytokine;Cytoplasm;Data;Development;Diagnosis;Disease;disease classification;Disparate;Dose;Dysmyelopoietic Syndromes;effective therapy;Enzymes;Failure;Fever;Genes;Genetic;genetic approach;Genetic Diseases;Genetic Polymorphism;genetic variant;Genotype;Hematologic Neoplasms;Hematology;Hematopoiesis;Hematopoietic;improved;Individual;Infiltration;Inflammation;Inflammatory;insight;Interferons;Interleukin-6;Lead;Life;Link;loss of function;Lung;Lymphoid;Lymphoid Cell;men;middle age;Missense Mutation;Modeling;Molecular;Molecular Diagnosis;mosaic;mosaic variant;mutant;Mutation;Myelogenous;Myeloid Cells;Names;NF-kappa B;novel;Onset of illness;Pathogenesis;Pathway interactions;patient stratification;Patients;Penetrance;peripheral blood;Plasma Cell Neoplasm;pleiotropism;Polyarteritis Nodosa;precursor cell;Prevalence;Protein Isoforms;Proteins;Public Health;Relapsing polychondritis;response;Rheumatism;risk stratification;Role;Signal Transduction;skin lesion;Somatic Mutation;Sorting;standard of care;Syndrome;Temporal Arteritis;Testing;Toxic effect;transcriptomics;Translations;Ubiquitin;Up-Regulation;Vacuole;Validation;Variant;Work

PROJECT_TITLE: Understanding the Role of Somatic Mutations in Adult Inflammatory Diseases


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: COLLEGE PARK

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: PROJECT NARRATIVE Individual-level risk factors are not fully explaining the large and persistent racial disparities in birth outcomes, limiting policy and intervention strategies to reduce these disparities. This project will advance our understanding of the potential effects of racial bias at a population level on the risk of preterm birth and low birth weight and identify protective factors to buffer its impact.

PI_NAMEs: NGUYEN, THU  (contact)

PROJECT_TERMS: Accounting;Address;adverse birth outcomes;Area;Biometry;Birth;Birth Rate;Birth Weight;Black Populations;Buffers;California;Characteristics;Childhood;Communities;community advisory board;community engaged research;County;Data;design;digital;disability;Disparity;disparity reduction;Emotional;Epidemiology;ethnic disparity;ethnic minority;Ethnic Origin;Event;evidence base;Feedback;Female;First Pregnancy Trimester;Focus Groups;Geographic Information Systems;Health;Health behavior;health disparity;Individual;Infant Mortality;innovation;Instagram;Intelligence;Intervention;Investigation;Label;Lead;Logistics;Low Birth Weight Infant;Low Prevalence;Machine Learning;machine learning model;Maps;Maternal Health;Measurement;Measures;Methods;Minority;Modeling;Mothers;Natural experiment;neural network;Not Hispanic or Latino;Outcome;Policies;Politics;Population;Pregnancy Trimesters;Premature Birth;Prenatal care;protective factors;Race;racial bias;racial difference;racial discrimination;racial disparity;racial identity;racial minority;racial prejudice;racism;Research;Research Design;resilience;Resources;Risk;Risk Factors;Role;Second Pregnancy Trimester;Site;social media;sociodemographics;statistics;stressor;Time;Time trend;time use;trend;Twitter;United States;Work

PROJECT_TITLE: Risk and strength: determining the impact of area-level racial bias and protective factors on birth outcomes.

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Stroke

ORG_CITY: CORAL GABLES

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Project Narrative: Endothelial cell dysfunction occurs early during aneurysm formation and may contribute to the failure of aneurysm treatment. Upon conclusion of this study, we will have an understanding of the role of IL-2 activated mTOR in endothelial cell dysfunction leading to aneurysm formation, progression and rupture. The expected positive impact of this multi-disciplinary research is that by enhancing our understanding and prevention of endothelial cell dysfunction in aneurysm pathogenesis, clinicians will have novel medical therapies, imaging modalities, and minimally invasive endovascular devices for the successful treatment of cerebral aneurysms.

PI_NAMEs: STARKE, ROBERT MICHAEL (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Alpha Interleukin 2 Receptor;Aneurysm;Angiography;Anti-Inflammatory Agents;atherosclerosis risk;B-Lymphocytes;Berry Aneurysm;Blood;Blood Vessels;brain endothelial cell;Catheters;Cell Physiology;Cell Proliferation;Cerebral Aneurysm;Cerebrum;Clinical Research;controlled release;cytokine;Data;Development;Devices;Endothelial Cells;endothelial dysfunction;Endothelium;Event;experimental study;Failure;Film;FRAP1 gene;Functional disorder;Gene Expression;Genes;Global Change;Grant;Growth;healing;Human;IL2 gene;imaging modality;in vivo imaging;in vivo Model;Inflammation;Inflammatory;inhibitor;innovation;Interdisciplinary Study;Interleukin 2 Receptor;Interleukin-2;Intervention;Knockout Mice;Lead;Ligation;Link;Macrophage;Magnetic Resonance Imaging;Maintenance;Mediating;Mediator;Medical;Microsurgery;minimally invasive;Modeling;Molecular;Molecular Analysis;Morbidity - disease rate;mortality;mouse model;mTOR inhibition;mTOR Inhibitor;mTOR protein;mTOR Signaling Pathway;Mus;Nanoporous;Neck;novel;Operative Surgical Procedures;Optical Coherence Tomography;Oral;Oryctolagus cuniculus;Oxidative Stress;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Population;Prevention;Process;Proliferating;Quantitative Reverse Transcriptase PCR;Recurrence;Regulation;repaired;Research;Retreatment;Risk;Risk Factors;Role;Rupture;Ruptured Aneurysm;Signal Transduction;Sirolimus;Stents;Surgical Clips;T-Lymphocyte;Technology;Testing;Therapeutic;Thinness;Tissues;Transgenic Mice;Treatment Failure;Up-Regulation;vascular abnormality;Vascular Diseases;vascular injury;Vasomotor

PROJECT_TITLE: Endothelial cell dysfunction in cerebral aneurysm pathogenesis


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Data Science;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pulmonary Hypertension

ORG_CITY: STANFORD

ORG_DEPT: SURGERY

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE We propose to develop and validate a core echocardiography artificial intelligence platform designed to extract the full density of information present in a standard echocardiogram. Echocardiography is a ubiquitous imaging modality, and such a system has an immediate impact on how we manage heart failure – a disease that affects an estimated 6.5 million people in the United States alone. Using our ECHO AI platform, we propose to build tools for surgical decision support and survival forecasting in patients with heart failure, and early screening tools to identify individuals at high risk of developing heart failure in the future.

PI_NAMEs: HIESINGER, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: FARAHANI, KEYVAN

PROJECT_TERMS: Accounting;Acute;Address;Affect;Apical;Artificial Intelligence;Artificial Intelligence platform;Benchmarking;Cardiac;Cardiovascular Diseases;Cardiovascular Surgical Procedures;Clinical;Clinical Data;clinical diagnosis;clinical practice;Cloud Computing;cohort;Color;community setting;Complex;computerized tools;cost effective;Data;Data Set;Decentralization;Decision Support Systems;density;design;Development;Devices;Diagnosis;Disease;disease diagnosis;early screening;Echocardiography;Effectiveness;Engineering;Event;Expert Systems;Failure;Framingham Heart Study;Future;Goals;Hand;Heart failure;heart function;high risk;Histopathology;Hospitals;Human;imaging modality;implantable device;improved;Individual;Informatics;Institution;International;left ventricular assist device;Life;machine learning framework;Manuals;Measurement;Medical;Medical Imaging;Methods;Modernization;mortality;Motion;multidimensional data;multimodality;Myocardial;Nature;novel;Operative Surgical Procedures;Outcome;outcome prediction;Patients;Pattern;Performance;Persons;Pharmacotherapy;point of care;Point-of-Care Systems;portability;Postoperative Complications;pulmonary arterial hypertension;Quality Control;radiomics;Research;Research Personnel;right ventricular failure;Risk;Scanning;screening;Screening procedure;Secure;Severities;Slide;Source;Survival Analysis;survival outcome;survival prediction;System;Techniques;temporal measurement;Thoracic Radiography;Time;tool;Training;Transplantation;United States;usability;Ventricular;Visual;Work

PROJECT_TITLE: Radiomics approach to engineering an artificial intelligence based echocardiography platform to predict cardiovascular surgery and heart failure outcomes.

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]