NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases

PROJECT_TERMS: 2019-nCoV;5' Untranslated Regions;Affinity;analytical ultracentrifugation;Antigens;arm;Binding;Binding Sites;Bioinformatics;Biological Assay;biophysical analysis;biophysical techniques;C-terminal;Cells;Cellular biology;Collaborations;Coronavirus;COVID-19;crosslink;dimer;Dimerization;Disease;DNA;experimental study;Hydrophobicity;inhibitor;Journals;Laboratories;Leucine;Ligands;Link;Liquid substance;Methods;mimetics;Modeling;Molecular Conformation;mutant;Mutation;Mutation Analysis;Nucleic Acid Binding;Nucleic Acids;Nucleocapsid;Nucleocapsid Proteins;Nucleotides;Occupations;Oligonucleotides;particle;Pathway interactions;Pharmaceutical Preparations;Phase;Phosphorylation;Photometry;Physical condensation;Play;Point Mutation;Process;protein oligomer;Proteins;Publishing;Reporting;Research;Ribonucleoproteins;RNA;Role;scaffold;Scaffolding Protein;sedimentation velocity;Serology;Single-Stranded DNA;Site;small molecule therapeutics;stem;Structural Models;targeted treatment;Techniques;Therapeutic;Therapeutic Intervention;therapeutic target;Viral;Viral Genome;Viral Packaging;viral RNA;Virion;Virus Assembly;Virus Diseases;virus testing;Virus-like particle

PROJECT_TITLE: Interactions of SARS-CoV-2 N-protein


ACTIVITY: ZIA

ADMINISTERING_IC: EB

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases

PI_NAMEs: SCHUCK, PETER  (contact)

PROJECT_TERMS: 2019-nCoV;Amino Acid Sequence;Amino Acid Substitution;Amino Acids;Antigens;Attention;Behavior;biophysical properties;Biophysics;Charge;Collaborations;Consensus Sequence;Coronavirus;Correlation Studies;COVID-19 pandemic;Databases;Disease;Distant;Docking;Drug Targeting;epidemiology study;Evolution;experimental study;flexibility;Follow-Up Studies;Frequencies;Genome;genome database;Genomics;Genotype;Geography;Hydrophobicity;indexing;Link;Mediating;mimicry;mutant;Mutation;mutation screening;Nucleocapsid;Nucleocapsid Proteins;Outcome;particle;Pathway interactions;Patients;Pattern;Phase;Phenotype;Property;protein function;protein protein interaction;Protein Region;Proteins;Publishing;Reporting;repository;Ribonucleoproteins;Role;Sampling;SARS-CoV-2 B.1.1.529;SARS-CoV-2 B.1.617.2;SARS-CoV-2 genome;scaffold;Site;Source;structural biology;Structure;Tertiary Protein Structure;therapeutic target;Thermodynamics;tool;Variant;variants of concern;Viral;Viral Genome;Viral Proteins;viral RNA;Virulence;Virus;Virus Assembly;Work

PROJECT_TITLE: The mutational landscape of SARS-CoV-2 nucleocapsid protein


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cancer;Cancer Genomics;Cardiovascular;Genetics;Hematology;Human Genome;Rare Diseases;Sickle Cell Disease;Women's Health Research

ORG_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

PI_NAMEs: PLATT, MANU  (contact)

PROJECT_TERMS: 3-Dimensional;Affect;Age;Amino Acid Sequence;Animals;Area;Arterial Disorder;Arteries;Atherosclerosis;Automobile Driving;Bioinformatics;Biomedical Engineering;Blood flow;Bone Diseases;Brain;Cardiac;Cardiovascular Diseases;Carotid Arteries;cathepsin K;Cathepsins;Cells;Circulation;Collaborations;Collagen;Common carotid artery;computerized tools;Cysteine;Data;Diagnostic;Diffusion Magnetic Resonance Imaging;Digital Imaging and Communications in Medicine;Disease;disease phenotype;Disease Progression;Drug Targeting;Elasticity;Elastin;Electron Microscopy;Elements;endometriosis;Enzymes;Equipment;Family;Genotype;Geometry;hemodynamics;Hemoglobin;Heterozygote;HIV;Human;Image;Infarction;interest;Kinetics;Knock-out;Liquid substance;Location;Magnetic Resonance Angiography;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant neoplasm of prostate;Mass Spectrum Analysis;mathematical model;Mechanics;Mediating;Medicine;meetings;Modeling;Molecular Biology;Molecular Profiling;mouse model;Mus;Mutation;National Institute of Biomedical Imaging and Bioengineering;Neoplasm Metastasis;novel;Output;pharmacologic;Physiological;Play;Postbaccalaureate;Postdoctoral Fellow;posters;protein expression;Protein Fragment;Proteins;Proteolysis;Publishing;Reaction;Recombinants;Research;Research Personnel;Role;Running;SARS-CoV-2 spike protein;Scholars Program;Scientist;serial imaging;shear stress;Sickle Cell;Sickle Cell Anemia;Sickle Cell Trait;sickling;Signal Pathway;simulation;single-cell RNA sequencing;Site;Societies;spatiotemporal;Stains;Stenosis;Stroke;Structure;summer internship;Surgeon;System;Tendinopathy;Testing;Thick;Thinness;Time;Tissues;trait;transcriptome sequencing;Transgenic Mice;United States National Institutes of Health;Up-Regulation;Vascular Diseases;Viral;Visualization;Work

PROJECT_TITLE: Mechanics and Tissue Remodeling Integrating Computational and Experimental Systems (MATRICES)


PI_NAMEs: FATHI, PARINAZ  (contact)

PROJECT_TERMS: Autoimmune Diseases;Autoimmunity;Bacterial Proteins;Biogenesis;Biological;Biology;Biomedical Engineering;Blood Vessels;Cell Culture Techniques;Cell Line;Cells;Collaborations;Communications Media;Development;Endothelial Cells;Engineering;Epitopes;Evaluation;experimental study;Extracellular Matrix;extracellular vesicles;Generations;Goals;Human;Hydrogels;Immune response;immunoengineering;Immunological Models;immunoregulation;instrument;interest;Investigation;Malignant neoplasm of thyroid;Malignant Neoplasms;Mammalian Cell;Mechanics;Microfluidic Microchips;Microfluidics;microphysiology system;Modeling;nanoengineering;nanoparticle;National Institute of Biomedical Imaging and Bioengineering;organ on a chip;Organoids;Phenotype;Property;Proteins;Proteomics;Protocols documentation;Research;Role;Sequence Homology;spheroids;systems research;Temperature;therapy development;Thyroid Gland;Tissues;zeta potential

PROJECT_TITLE: NanoEngineering and MicroPhysiological Systems


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Lung;Tobacco;Tobacco Smoke and Health

PI_NAMEs: LONDON, STEPHANIE  (contact)

PROJECT_TERMS: Address;Adult;Blood;Bone Marrow;causal variant;Childhood Asthma;design;Disease;Epidemiology;epidemiology study;Epigenetic Process;epigenome;epigenome-wide association studies;Experimental Models;experimental study;exposure to cigarette smoke;follow-up;Genes;Genetic;genetic analysis;Genome;genome wide association study;Human;Human Genome;Immunity;Inflammation;Intervention;Journals;Knock-out;Knockout Mice;Laboratories;Life Cycle Stages;London;Lung;metabolomics;Methylation;Mothers;mouse model;Mus;Newborn Infant;novel;Paper;Pathway interactions;Phenotype;Proteomics;Publishing;pulmonary function;Respiratory Disease;Role;Sampling;Smoke;Smoking;smoking-related disease;Smooth Muscle;Statistical Data Interpretation;Testing;Tissues;trait;transcriptome sequencing;Wild Type Mouse

PROJECT_TITLE: Genetic Analyses For Epidemiologic Studies Of Respiratory Disease


NIH_SPENDING_CATS: Cardiovascular;Contraception/Reproduction;Diabetes;Maternal Health;Maternal Morbidity and Mortality;Precision Medicine;Pregnancy;Prevention;Women's Health Research

ORG_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

PI_NAMEs: WEINBERG, CLARICE  (contact)

PROJECT_TERMS: Archives;Area;Beta Cell;Biological Assay;biological specimen archives;Budgets;cardiovascular disorder risk;Case/Control Studies;cohort;Cohort Analysis;Cohort Studies;Collaborations;Complication;Cost efficiency;Data;design;Disease;disorder risk;Enrollment;Environmental Risk Factor;Epidemiologic Methods;Epidemiology;follow-up;Genetic Predisposition to Disease;Gestational Diabetes;Health;human data;Hypertension;improved;Learning;Measures;Medical History;Methods;Non-Insulin-Dependent Diabetes Mellitus;non-linear transformation;Observational Study;Outcome;Pancreas;personalized approach;Persons;Physiological;Postdoctoral Fellow;Pregnancy;Pregnancy Complications;Pregnancy Histories;Pregnancy loss;Prevention;prospective;Recording of previous events;Recurrence;reproductive;Reproductive History;Research Design;Research Personnel;Risk;risk prediction;Sampling;screening;simulation;Sister;Specimen;Statistical Methods;tool;undergraduate student;Woman;Women's mortality;Work

PROJECT_TITLE: Statistical Methods In Epidemiology--general


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

PROJECT_TERMS: Affect;Age;Algorithms;Asian;autism spectrum disorder;Back;Biological;Blood Pressure;case control;Chromosome Mapping;Cleft Lip;Cleft Palate;Collaborations;Complex;Congenital Abnormality;Data;Data Set;Defect;design;Detection;Disease;disorder risk;early onset;Environment;Environmental Exposure;Environmental Risk Factor;Etiology;European;Evolution;extreme prematurity;Family;fetal;First Degree Relative;Future;gene environment interaction;Genes;Genetic;genetic epidemiology;Genetic Epistasis;Genetic Programming;Genetic study;genetic variant;genome wide association study;genomic data;Genotype;Health;Heritability;improved;Individual;Joints;laboratory development;Life;Linkage Disequilibrium;Machine Learning;Malignant Breast Neoplasm;maternal cigarette smoking;Mediating;Methods;Modeling;molecular subtypes;novel strategies;oral cleft;Outcome;Paper;Parents;Pathway interactions;Pennsylvania;Phenotype;Pregnancy Complications;prenatal;Proxy;Recurrence;Risk;Severities;Siblings;Signal Transduction;simulation;Sister;smoking during pregnancy;Source;Statistical Methods;Structure;Subcategory;summer student;Survivors;Testing;Toy;trait;Universities;Variant;Work

PROJECT_TITLE: Statistical Methods For Genetic Epidemiology


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Chronic Obstructive Pulmonary Disease;Genetics;Heart Disease;Human Genome;Lung;Prevention;Social Determinants of Health

PROJECT_TERMS: Adult;Adult asthma;Adverse effects;African ancestry;Aging;Agriculture;Air Pollution;Allergic Disease;ambient air pollution;Asthma;Atherosclerosis Risk in Communities;Biological Markers;Candidate Disease Gene;Cardiovascular Diseases;Cardiovascular system;causal variant;Chronic Obstructive Pulmonary Disease;cohort;Cohort Studies;Collaborations;Communities;Data;Development;Diet;Disease;Early identification;Environment;Environmental Exposure;Environmental Risk Factor;environmental tobacco smoke;Epigenetic Process;epigenome;Etiology;European;European ancestry;exome;Exposure to;Extramural Activities;Farm;Funding;Genes;Genetic;Genetic Predisposition to Disease;Genetic Risk;Genetic Variation;Genome;genome wide association study;genome wide methylation;genome-wide;Genomic approach;genomic epidemiology;Genomics;Genotype;Goals;Health;Heart;Heart Diseases;Impairment;Individual;Inhalation;interest;Joints;Life Cycle Stages;longitudinal analysis;Lung;Mediating;Meta-Analysis;metabolomics;Methods;Methylation;microbiome;microbiome analysis;mouse model;multi-ethnic;National Heart, Lung, and Blood Institute;National Institute of Environmental Health Sciences;next generation sequencing;novel;novel marker;Occupational;Occupational Exposure;Outcome;Paper;Pesticides;Phenotype;pollutant;Population;Population Study;Predisposition;prescription opioid;Proteomics;Publications;Publishing;pulmonary function;rare variant;Research;Resistance;Resources;respiratory;Respiratory Disease;respiratory health;Role;Smoking;Special Population;targeted sequencing;Tobacco smoking behavior;traffic-related air pollution;trait;Variant;Visit;Vital capacity;whole genome;Work

PROJECT_TITLE: Genetics and Environment in Adult Respiratory, Allergic and Cardiac disease


NIH_SPENDING_CATS: Asthma;Conditions Affecting the Embryonic and Fetal Periods;Genetics;Human Genome;Lung;Maternal Health;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health;Women's Health Research

PROJECT_TERMS: Adult;Adverse effects;African;Age;Air Pollution;alcohol consumption during pregnancy;Allergic;Asthma;atopy;bead chip;Biological;biomarker development;Biomass;Birth;Birth Order;Birth Weight;Blood specimen;Body mass index;Caffeine;Carbon;Child;Child Health;Childhood;Childhood Asthma;cohort;Cohort Studies;Collaborations;Country;Data;Developed Countries;Development;Diet;Disease;DNA;DNA Methylation;early childhood;early life exposure;Education;Environmental Exposure;Environmental Risk Factor;Epidemiology;Epigenetic Process;epigenome;epigenome-wide association studies;Etiology;Exposure to;Family;Folic Acid;follow-up;Food;Funding;Future;Genes;Genetic;Genome;genome wide association study;Genotype;Gestational Age;Gestational Diabetes;Health;high risk;Home;human disease;Hypersensitivity;in utero;Infant;Inflammation;Inhalant dose form;Intake;interest;International;Life;Life Cycle Stages;maternal anxiety;maternal cigarette smoking;Maternal Exposure;maternal hypertension;maternal stress;Measures;Meta-Analysis;Metabolism;Methylation;Morbidity - disease rate;mortality;Mothers;National Institute of Environmental Health Sciences;Newborn Infant;Nigeria;Norway;novel;Nutrient;offspring;Outcome;Paper;Parental Ages;Parents;Pathway interactions;Phenotype;Pilot Projects;Population;population based;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Pregnancy;pregnancy hypertension;Pregnant Women;prenatal;prenatal exposure;Public Health;Publications;Publishing;Questionnaires;Recommendation;Recording of previous events;Research;Research Personnel;Resources;respiratory;response;Risk Factors;Role;Sample Size;Sampling;School-Age Population;season of birth;Signal Transduction;Smoking;smoking during pregnancy;Stressful Event;success;time use;Umbilical Cord Blood;United States National Institutes of Health;Work

PROJECT_TITLE: Genetic And Environmental Factors In Childhood Respiratory and Allergic Illness


NIH_SPENDING_CATS: Genetics

PI_NAMEs: HALL, TRACI M (contact)

PROJECT_TERMS: Affinity;Binding;Biochemical;Biochemistry;Biological;Biological Assay;Biological Models;biological systems;C-terminal;Cancer Biology;Cells;Collaborations;Complex;Cryoelectron Microscopy;Cues;Data;Development;Developmental Biology;Embryonic Development;environmental change;Enzyme Kinetics;Enzymes;Essential Genes;Exclusion;fascinate;fundamental research;Future;Gene Expression;Gene Expression Regulation;genetic regulatory protein;Germ Lines;Goals;Group Structure;human disease;In Vitro;in vivo;Knowledge;Lateral;Messenger RNA;Molecular;Molecular Structure;Pathway interactions;Phase;Play;Post-Transcriptional Regulation;Process;Property;protein complex;protein function;Proteins;Regulation;Regulatory Pathway;Repression;Reproduction;Research;response;RNA;RNA Binding;RNA Processing;RNA Recognition Motif;RNA-Binding Proteins;RNA-Protein Interaction;Role;Signal Transduction;Site;Specificity;stem cell biology;Stimulus;structural biology;Structure;Tail;Techniques;Touch sensation;Toxicology;Transfer RNA;Visualization;Work;X-Ray Crystallography

PROJECT_TITLE: Structural Studies Of Post-Transcriptional Gene Regulation


PI_NAMEs: KUNKEL, THOMAS A (contact)

PROJECT_TERMS: Biochemical;Cell Death;Cell Survival;Coupling;Digestion;DNA biosynthesis;DNA Double Strand Break;DNA polymerase beta2;DNA Repair;DNA Structure;DNA-Directed DNA Polymerase;Genetic;Genome;Genome Stability;Genomics;Goals;Health;in vivo;Mediating;Mitotic;Mus;Mutagenesis;Nonhomologous DNA End Joining;Nucleotides;Pathway interactions;Phosphodiesterase I;Polymerase;Process;Property;Publications;repaired;Stress;Structure;Tail;Variant;Yeasts

PROJECT_TITLE: Structure-Function Studies Of DNA Replication Fidelity


PI_NAMEs: COPELAND, WILLIAM  (contact)

PROJECT_TERMS: 5'-deoxyribose phosphate lyase;Affect;Affinity;Age;Alpers' Syndrome;Animals;Apoproteins;Apoptosis;Area;Atomic Force Microscopy;base;Base Excision Repairs;Binding;Binding Proteins;Binding Sites;Catalytic Domain;Cells;Chemicals;Child;Chronic progressive external ophthalmoplegia;Clinical;clinically relevant;Complex;crosslink;Cryoelectron Microscopy;Data;Defect;dimer;Disease;DNA;DNA Binding;DNA biosynthesis;DNA Maintenance;DNA polymerase gamma;DNA Repair;DNA replication fork;DNA Structure;DNA-Directed DNA Polymerase;Dysarthria;Frequencies;Gene Proteins;General Population;Genes;Genetic;Genetic Diseases;genetic regulatory protein;Goals;helicase;Human;Impairment;Individual;Inherited;insight;Intervention;Link;Mass Spectrum Analysis;Mediating;Metabolic Diseases;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;mitochondrial genome;Modeling;Molecular;Mutagenesis;Mutation;neuromuscular;Neuropathy;Nuclear;Ophthalmopareses;Organ;oxidative damage;Parkinsonian Disorders;particle;Pathogenicity;Pathology;Phosphodiesterase I;Point Mutation;Polymerase;polymerization;Polymers;Premature aging syndrome;Premature Menopause;Prevalence;prevent;Prevention;Process;Production;Proteins;Proteolysis;Publishing;Regulation;repaired;Reporting;Risk;Roentgen Rays;Role;Sensory;Single-Stranded DNA;Site;Site-Directed Mutagenesis;SS DNA BP;Structure;Symptoms;System;Time;Variant;Work;X-Ray Crystallography

PROJECT_TITLE: Molecular Characterization Of The Mitochondrial Dna Polymerase


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention

PROJECT_TERMS: 3 year old;abacavir;Address;Adult;aged;Amino Acids;analog;Animals;Anti-viral Therapy;antiretroviral therapy;antiviral nucleoside analog;Birth;Characteristics;Child;Collaborations;cost effective;deoxyguanosine triphosphate;design;Didanosine;dideoxynucleotide;Disease;DNA;DNA analysis;DNA biosynthesis;DNA polymerase gamma;DNA-Directed DNA Polymerase;Dose;Erythrocebus patas;Event;Excision;Exposure to;Fiber;Future;genetic variant;Genome;Genomic DNA;Goals;Health;Heart;HIV;Human;Iatrogenesis;improved;In Vitro;Individual;inhibitor;Kinetics;Laboratories;Lamivudine;Libraries;Life;Methods;Mitochondria;Mitochondrial DNA;mitochondrial DNA alteration;mitochondrial DNA mutation;Mus;Muscle Mitochondria;Myopathy;Neuropathy;Nevirapine;next generation sequencing;Nuclear;nucleoside analog;nucleotide analog;Nucleotides;Patients;Persons;Pharmaceutical Preparations;pinacolyl methylphosphonic acid;Point Mutation;Polymerase;Predisposition;pregnant;Pregnant Women;prenatal exposure;Preparation;prevent;Procedures;Property;Protocols documentation;Publishing;Recombinant DNA;Risk;Role;Sampling;side effect;Stavudine;Tenofovir;Tissues;Toxic effect;tripolyphosphate;Vertical Disease Transmission;Vertical Transmission;Viral;Virus;Zalcitabine;Zidovudine

PROJECT_TITLE: Human Mitochondrial Dna Polymerase With Anti-hiv Nucleotides


PI_NAMEs: SCHAAPER, ROELAND  (contact)

PROJECT_TERMS: Address;Adverse effects;Affect;Allosteric Regulation;base;Base Pairing;Biochemical;Cells;Chromosomes;Dissociation;DNA;DNA biosynthesis;DNA Polymerase II;DNA Polymerase III;DNA replication fork;DNA-Directed DNA Polymerase;Enzymes;Escherichia coli;Exclusion;Genes;Genetic;Holoenzymes;In Vitro;in vivo;Individual;Laboratory Study;Measures;Mismatch Repair;model organism;mutant;Mutation;Mutation Detection;novel;Play;Polymerase;Process;Protein Complex Subunit;Protein Subunits;Replication Error;Ribonucleotide Reductase;Role;Sequence Analysis;SOS Response;Source;Specificity;Speed;System

PROJECT_TITLE: Mechanisms Of E. coli Replication Fidelity


NIH_SPENDING_CATS: Genetics;Human Genome

PROJECT_TERMS: Apoptosis;base;Base Pairing;Biochemistry;Cell Survival;Degenerative Disorder;deoxyguanosine triphosphate;Development;Discrimination;Disease;DNA;DNA biosynthesis;DNA Damage;DNA Ligases;DNA Ligation;DNA Sequence;endonuclease;Environment;Eukaryotic Cell;Event;Excision Repair;gene repair;Genetic;Genetic Recombination;Genome;genome sequencing;Genome Stability;Goals;Health;Human;Immune response;Immunoglobulin Genes;Immunoglobulin Somatic Hypermutation;Infertility;Inherited;insertion/deletion mutation;Lead;Ligation;Malignant Neoplasms;Meiotic Recombination;Mismatch Repair;MSH2 gene;Mutagenesis;mutant;Mutation;Nuclear;Nucleotides;Okazaki fragments;Polymerase;preference;prevent;protein function;Proteins;repaired;replicase;Replication Error;response;Ribonucleotides;Role;Saccharomyces cerevisiae;seal;Signal Transduction;Single base substitution;System;Trinucleotide Repeats;Variant;whole genome;Yeasts

PROJECT_TITLE: Studies Of DNA Mismatch Repair


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Regenerative Medicine;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

PI_NAMEs: ARCHER, TREVOR KEITH (contact)

PROJECT_TERMS: 26S proteasome;Acute;Affect;African American population;Age;Aging;American;Animals;anti-cancer;Architecture;Area;ATP phosphohydrolase;Attention;Auxins;Binding;biological research;brahma;Breast Cancer Cell;Bromodomain;cancer cell;Cell Aging;Cell Line;Cell Reprogramming;Cell surface;Cells;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Collaborations;Collagen;Communication;Complex;Computer software;Cues;Data;Deoxyribonuclease I;Dermal;Development;Disease;Distal;DNA;Dorsal;embryonic stem cell;Energy Metabolism;Enhancers;Ensure;environmental health disparity;Environmental Impact;environmental justice;Enzymes;EP300 gene;Epigenetic Process;Epithelium;Eukaryotic Cell;European;Exhibits;Extracellular Matrix;Fibroblasts;fluorescence microscope;Gene Expression;Gene Expression Regulation;Genes;genetic information;Genetic Transcription;Genome;genomic locus;Genomics;Geroscience;global health;Glucocorticoid Receptor;Goals;Health;heart function;Heterogeneity;Histone Acetylation;Homeostasis;Human;human embryonic stem cell;human pluripotent stem cell;Immune response;improved;induced pluripotent stem cell;insight;Knock-in;Length;life span;Ligands;machine learning pipeline;Malignant Neoplasms;Mammary Neoplasms;Mediating;Mesenchymal;MG132;Mission;Molecular;Morphology;multicatalytic endopeptidase complex;Mus;Mutate;National Heart, Lung, and Blood Institute;National Institute of Environmental Health Sciences;nerve stem cell;Neural Crest;Neuroectoderm;Neuronal Differentiation;Normal Cell;Nuclear;Nuclear Receptors;Nucleic Acids;Nucleosomes;Oncogenic;outreach;Pathologic;Patient Self-Report;Phenotype;Physiological;Physiology;Play;pluripotency;Pluripotent Stem Cells;Positioning Attribute;Post-Translational Protein Processing;Process;Production;programs;promoter;Proteasome Inhibitor;protein degradation;Proteins;Pseudopodia;Publishing;receptor;Reproduction;Research;RNA;RNA Polymerase II;Role;Sampling;senescence;sex;Signal Transduction;Site;small molecule inhibitor;SMARCA2 gene;SMARCA4 gene;Specific qualifier value;stem cell biology;Stem cell pluripotency;stem cells;Strategic Planning;Surface;SWI/SNF Family Complex;System;Therapeutic;Training;Transcript;transcription factor;Transcription Initiation;Transcription Initiation Site;transcriptomics;Trichostatin A;Tumor Subtype;Ubiquitin;Variant;Work

PROJECT_TITLE: Epigenetic and Transcriptional Functions of Nuclear Receptors and Chromatin Remodeling Proteins in Stem and Cancer Cells


NIH_SPENDING_CATS: Lung

PI_NAMEs: CIDLOWSKI, JOHN A. (contact)

PROJECT_TERMS: Asthma;Behavior;biological adaptation to stress;blood glucose regulation;Cell Death;Cell Differentiation process;cell growth;Cells;Chronic;connective tissue metabolism;Disease;Drug Prescriptions;Evaluation;Glucocorticoids;Goals;Growth;Health;Hormones;Human;hypothalamic-pituitary-adrenal axis;Immunologic Surveillance;Inflammatory;insight;Life;man;Mission;National Institute of Environmental Health Sciences;Physiology;protein metabolism;Respiratory physiology;Signal Pathway;Signal Transduction;skeletal;Stress;therapeutic development;Therapeutic Intervention;Tissues

PROJECT_TITLE: Glucocorticoid Hormone Action


NIH_SPENDING_CATS: Arthritis;Biotechnology;Genetics

PI_NAMEs: BLACKSHEAR, PERRY J (contact)

PROJECT_TERMS: 3' Untranslated Regions;Acquired Immunodeficiency Syndrome;Anabolism;Arthritis;Binding;Biochemical;Biological Assay;Caenorhabditis elegans;Cell Nucleus;Cells;Cessation of life;Chronic;Complex;Crohn's disease;Cytosol;Dermatitis;Dictyostelium;Disease;Drosophila melanogaster;drug development;Elements;Evaluation;Excision;Family;Family member;Fission Yeast;Gene Expression Regulation;Gene Family;Genes;Genetic Polymorphism;Genetic Transcription;Genome;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Growth Factor;Health;Human;Inflammation;Inflammatory;inhibitor;insight;Knockout Mice;Lead;Macrophage;Malignant Neoplasms;man;Mediating;Medical;member;Messenger RNA;mRNA Transcript Degradation;Mus;National Institute of Environmental Health Sciences;new therapeutic target;novel;novel therapeutics;Organism;Pathway interactions;Phenotype;Phosphorylation;Physiological;Poly(A) Tail;Process;Proteins;prototype;Regulation;response;Rheumatoid Arthritis;Rodent;screening;Serine;small molecule;Stimulus;Syndrome;TIS11 protein;TNF gene;transcriptome;Variant;wasting;ZFP36L2 gene;Zinc Fingers

PROJECT_TITLE: TTP and related proteins in the regulation of gene expression


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Emerging Infectious Diseases;Infectious Diseases;Neurodegenerative;Neurosciences;Parkinson's Disease;Tobacco

PI_NAMEs: YAKEL, JERREL L (contact)

PROJECT_TERMS: 2019-nCoV;Acetylcholine;Acute Disease;alpha-bungarotoxin receptor;Alzheimer's Disease;Alzheimer's disease patient;Amygdaloid structure;Anesthesia procedures;Animals;antagonist;Area;Behavioral;behavioral outcome;Binding;Binding Sites;Biophysics;Brain;brain control;Brain Injuries;Brain region;Cell Count;Cells;cholinergic;Cholinergic Receptors;Chronic;cognitive ability;Cognitive deficits;cognitive function;cognitive process;Communication;Corpus striatum structure;dentate gyrus;Development;Diffusion;disorder risk;Disputes;Dopamine;dopaminergic neuron;drinking water;Electrophysiology (science);entorhinal cortex;environmental agent;epidemiologic data;Epilepsy;Event;excitatory neuron;Exposure to;Fire - disasters;frontier;Functional disorder;Genetic;Genetic Transcription;granule cell;Hippocampus;Human;Impaired cognition;Impairment;improved;in utero;Individual;Infection;Infusion procedures;Insecticides;Interneurons;Ion Channel Gating;Journals;Knock-out;Ligands;Link;Location;male;Maps;Memory;memory consolidation;memory encoding;Memory impairment;Memory Loss;memory retrieval;Molecular;motor disorder;Mus;Muscarinic Acetylcholine Receptor;Mutation;National Institute of Environmental Health Sciences;Nature;Nervous System;Neurodegenerative Disorders;neurogenesis;Neurologic;Neurons;Neurosciences;neurotransmitter release;neurovirulence;Nicotine;nicotine exposure;Nicotinic Receptors;novel;Paper;Parkinson Disease;Pathology;Pathway interactions;Patients;Pattern;Physiological;Physiological Processes;Play;Postsynaptic Membrane;Pregnant Women;Presynaptic Terminals;prevent;Process;Publishing;Pyramidal Cells;Rattus;receptor;Regulation;Reporting;Reversal Learning;Reverse Transcriptase Polymerase Chain Reaction;Risk;Role;Rotenone;Schizophrenia;Severities;sex;Site;Slow-Wave Sleep;Smoke;Substantia nigra structure;Symptoms;Synapses;Synaptic Cleft;Synaptic Transmission;Techniques;Testing;Therapeutic;Tobacco Dependence;Training;transmission process;Urethane;voltage clamp;voltage/patch clamp;Work

PROJECT_TITLE: Modulation Of Neuronal Channels and Receptors in the Brain


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

PI_NAMEs: DUDEK, SERENA M (contact)

PROJECT_TERMS: Address;Adenosine A1 Receptor;Adult;Age;Agglutinins;aggrecan;Aggressive behavior;Animal Experiments;Animals;antagonist;Antibodies;Area;autism spectrum disorder;Axon;Behavior;behavior influence;Biochemical;Brain;brain circuitry;Brain region;Buffers;Caffeine;Calcium;Cell Nucleus;Cells;Chemosensitization;cognitive development;Collaborations;Collection;Corticosterone;Data;Dendritic Spines;dentate gyrus;Development;developmental disease;Electrophysiology (science);Embryo;Endocrine disruption;Environment;Environmental Exposure;Environmental Health;Environmental Risk Factor;Exhibits;experimental study;Exposure to;Extracellular Matrix;Fluorescence;Future;G-Protein-Coupled Receptors;Genes;Goals;GTP-Binding Protein Regulators;Hamsters;hippocampal subregions;Hippocampus;Hormonal;Hormone Receptor;Hormones;Human;Imaging Techniques;Immunofluorescence Immunologic;Impairment;Implant;in utero;In Vitro;in vivo;insight;interest;Investigation;Knock-out;Knockout Mice;Lasers;Learning;Life;Ligands;Long-Term Depression;Long-Term Potentiation;Mass Spectrum Analysis;Measures;Memory;memory recognition;Mental disorders;Messenger RNA;Methods;Microscopy;Microtus;Mineralocorticoid Receptor;Mitochondria;Modification;Molecular;Molecular Profiling;Morphology;mossy fiber;mouse model;Mus;Neonatal;neonatal brain;neonate;Nervous System;Neuroanatomy;neurobehavioral;Neurons;Neuropeptides;novel;NR3C2 gene;Organism;Oxytocin;Pair Bond;patch clamp;Pattern;pharmacologic;Physiological;Physiology;Plant Lectins;Play;postnatal;postnatal development;postnatal period;Predisposition;preference;Pregnancy;premature;prenatal;Process;Publications;Pyramidal Cells;Rattus;receptor;receptor function;Receptor Signaling;Regulation;Research;Resistance;response;Rett Syndrome;Rodent;Role;Sensory;Serum;Signal Transduction;Slice;social;Social Behavior;social cognition;Spironolactone;Stains;Stress;Structure;Synapses;Synaptic plasticity;Techniques;Testing;Tissue Stains;Tissues;Toxic Environmental Substances;toxicant;transcription factor;transcriptome sequencing;treatment group;Vasopressins;vesicular glutamate transporter 2;Wisteria

PROJECT_TITLE: Mechanisms Of Synaptic Plasticity In The Adult And Developing Nervous System


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Hematology;Human Genome;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases;Tobacco;Tobacco Smoke and Health

PI_NAMEs: BELL, DOUGLAS  (contact)

PROJECT_TERMS: adaptive immunity;Adult;Affect;B-Cell Activation;B-Lymphocytes;Binding;Biogenesis;Bioinformatics;Biological;Biological Assay;Biological Markers;Birth;Birth Weight;Blood Cells;Blood specimen;Bronchopulmonary Dysplasia;Categories;CD14 gene;CD19 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;cDNA Arrays;Cell Aging;Cell Cycle;Cell Cycle Progression;Cell Line;cell type;Cells;Cytokine Signaling;Cytokinesis;Data Set;design;Development;Developmental Gene;differential expression;Disease;Disease susceptibility;disorder risk;DNA;DNA Damage;DNA Methylation;DNA Sequence;early detection biomarkers;Environment;Environmental Exposure;epigenetic marker;Epigenetic Process;epigenetic variation;epigenome;epigenome-wide association studies;epigenomic profiling;Erythroblasts;Event;Exposure to;functional genomics;Future;Gene Expression;Genes;Genetic;Genetic Polymorphism;Genetic Variation;genome wide association study;genome-wide;Genomic approach;Genomics;Genotype;Gestational Age;Goals;granulocyte;Health;Hematologic Neoplasms;Hematopoiesis;Homeostasis;Human;human tissue;Immune;Impairment;improved;Incidence;Infant;Infection;Inflammatory Response;insight;late life;Leukocytes;Leukopoiesis;Linear Regressions;Link;Linkage Disequilibrium;Lung;Lung Diseases;lung maturation;Lymphocyte;Lymphopoiesis;Memory B-Lymphocyte;Methods;Methylation;Microarray Analysis;Mission;Mitochondria;Molecular;monocyte;Mutation;Natural Immunity;Natural Killer Cells;NCAM1 gene;neonatal care;neonatal period;neonate;Nervous System Disorder;neutrophil;Neutrophil Activation;non-smoker;nucleotide metabolism;Organ;Oxygen;Oxygen Therapy Care;Pathogenesis;Pathway interactions;peripheral blood;Phagocytosis;Phenotype;Population Study;precision medicine;Predisposition;premature;Premature Infant;preterm newborn;Prevention;Prevention strategy;promoter;prospective;pulmonary function;Regression Analysis;Reproducibility;response;Response Elements;Risk;Risk Assessment;RNA;Signal Pathway;Single Nucleotide Polymorphism;Site;Smoker;Smoking;supplemental oxygen;Supplementation;Survival Rate;T-Lymphocyte;Techniques;Therapeutic;tobacco smoke exposure;Tobacco smoking behavior;TP53 gene;trait;transcriptome;transcriptome sequencing;transcriptomics;Umbilical Cord Blood;Variant;verification and validation;Whole Blood;Work

PROJECT_TITLE: Discovery And Functional Genomics Of Environmental Response Genes


NIH_SPENDING_CATS: Aging;Congenital Structural Anomalies;Diabetes;Eye Disease and Disorders of Vision;Genetics;Human Genome;Kidney Disease;Neurosciences;Pediatric;Polycystic Kidney Disease;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: JETTEN, ANTON M (contact)

PROJECT_TERMS: Alzheimer's Disease;anterior chamber;Astrocytes;Atrophic;Beta Cell;Binding;Binding Sites;Cell Differentiation process;Cell Physiology;Cell Proliferation;Characteristics;ChIP-seq;Chronic Kidney Failure;Complex;Cystic Kidney Diseases;Development;Diabetes Mellitus;Embryo;Embryonic Development;Endocrine;EP300 gene;Ependymal Cell;Epithelium;Exhibits;Exophthalmos;Fibrosis;Functional disorder;gene environment interaction;Gene Expression;gene function;gene repression;Generations;Genes;Genetic Transcription;genome wide association study;Glaucoma;GLIS2 gene;Goiter;hormone biosynthesis;Human;human disease;Hypothyroidism;Immune response;Infertility;Inflammation;Inflammatory;insight;Insulin;insulin regulation;interest;Iodides;Kidney;Kidney Failure;Knockout Mice;Laboratories;Liquid substance;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;Mass Spectrum Analysis;member;Metabolic;Mitochondria;Mus;Mutation;neonatal diabetes mellitus;Nephronophthisis;novel;novel therapeutic intervention;Osteoblasts;overexpression;Pancreas;pancreas development;Pancreatic duct;Pathology;Physiologic Intraocular Pressure;Physiological;Play;Polycystic Kidney Diseases;Post-Translational Protein Processing;postnatal;premature;Production;progenitor;promoter;Promoter Regions;Proteins;recruit;Regulation;Renal function;Role;scaffold;Signal Pathway;Single Nucleotide Polymorphism;single-cell RNA sequencing;sperm cell;Spermatogenesis;Spermatogonia;stem cells;Structure of beta Cell of islet;Syndrome;Thyroid Function Tests;Thyroid Gland;Thyroid Hormones;Tissues;Trabecular meshwork structure;transcription factor;Transcriptional Regulation;Wild Type Mouse;Zinc Fingers

PROJECT_TITLE: Mechanism Of Action And Functions Of The Gli-related Proteins Glis 1-3


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Climate-Related Exposures and Conditions;Clinical Research;Genetics;Human Genome;Microbiome;Pediatric;Prevention;Rare Diseases;Scleroderma;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PI_NAMEs: RIDER, LISA  (contact)

PROJECT_TERMS: 2019-nCoV;Adolescent;Adult;Affect;Age;Air;Air Pollution;Alcohol consumption;Alleles;American;Animal Model;Antibodies;Antinuclear Antibodies;Area;Aryl Hydrocarbon Receptor;Autoantibodies;Autoimmune;Autoimmune Diseases;autoimmune pathogenesis;Autoimmunity;B-Lymphocytes;BCL2 gene;Biological;Biological Products;Blood;Candidate Disease Gene;Caucasians;Cause of Death;CCR5 gene;Child;Chronic;Chronic Disease;Clinical;Collaborations;Complement component C4a;Complex;Cytokine Receptors;Cytoplasmic Granules;Data;Dermatomyositis;Development;Diagnosis;Diagnostic;Dioxins;Disease;disease diagnostic;Dust;dysbiosis;environmental agent;Environmental Exposure;Environmental Risk Factor;Enzymes;Epidemiology;Estrogens;European ancestry;Evaluation;Exposure to;Family;Family Study;Flagellin;Food;Gene Expression;Genes;Genetic;genetic association;genetic risk factor;Genetic Transcription;genome wide association study;genome-wide;Geography;Goals;Granzyme;gut bacteria;gut microbiome;Haplotypes;Herpes zoster disease;High Prevalence;HLA-DRB1;Hormones;Idiopathic Inflammatory Myopathies;Immune;immune activation;Immunologic Markers;Immunologics;improved;Individual;Infectious Agent;Inflammation;Inflammatory;Interferons;Investigation;Juvenile Dermatomyositis;Laboratories;Learning;Life;Lung Diseases;Major Histocompatibility Complex;Malignant Neoplasms;MAP Kinase Gene;Measures;Molecular Genetics;Monozygotic twins;Morbidity - disease rate;mortality;multidisciplinary;Muscle;Myopathy;Myositis;National Health and Nutrition Examination Survey;national surveillance;neutrophil;Not Hispanic or Latino;novel;Obesity;Occupational Exposure;older adult;Onset of illness;oral microbiome;Organic solvent product;p38 Mitogen Activated Protein Kinase;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway Analysis;Pathway interactions;patient registry;Patients;Pattern;Peripheral;Pharmaceutical Preparations;Phenotype;PI3K/AKT;Polychlorinated Biphenyls;Polymyositis;Population;Predisposition;Pregnancy;Prevalence;Prevention strategy;proband;prognostic;protective factors;Proteins;Proteomics;prototype;Recording of previous events;Recurrence;Registries;Research Personnel;Rheumatoid Arthritis;Risk;Risk Factors;Role;Sampling;Scleroderma;Seasons;Siblings;Signal Transduction;Silicon Dioxide;Single Nucleotide Polymorphism;Sirtuins;Skin;Smoker;Smoking;STAT4 gene;Stressful Event;Subgroup;Sunburn;surveillance data;Syndrome;systemic autoimmune disease;Systemic Lupus Erythematosus;Systemic Scleroderma;T-Lymphocyte;Therapeutic;Tobacco smoke;Tobacco smoking behavior;Transcript;transcription factor;trend;Ubiquitination;Ultraviolet Rays;United States;Up-Regulation;Vaccination;Virus;Water;whole genome;Xenobiotics;young woman

PROJECT_TITLE: Environmental/genetic Risk Factors and Pathogenesis of Autoimmune Disease


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Orphan Drug;Pediatric;Prevention;Rare Diseases

PROJECT_TERMS: Adolescent;Adult;Agreement;American;Anti-Inflammatory Agents;Area;Assessment tool;Autoimmune Diseases;B-Lymphocytes;Binding;Biological;Biological Models;Calcinosis;Categories;Characteristics;chemokine;Child;Childhood;Classification;classification trees;Clinical;Clinical Research;Clinical Trials;Clinical Trials Design;Collaborations;college;Conduct Clinical Trials;Consensus;Data;data repository;Data Set;Dermatomyositis;Development;Disease;Disease Outcome;Down-Regulation;drug efficacy;Early treatment;Educational Materials;effective therapy;efficacy evaluation;Elements;Environmental Risk Factor;ESR1 gene;European;Future;Gene Expression;Gene Expression Profile;Genes;Goals;Guidelines;Heterogeneity;Idiopathic Inflammatory Myopathies;Immune;immune activation;Immunosuppression;improved;In Vitro;indexing;Inflammation;interest;Interferons;International;Janus kinase;kinase inhibitor;Laboratories;Life;Low Dose Radiation;Malignant Neoplasms;Measurement;Measures;Mediating;medical specialties;member;MicroRNAs;Modeling;Morbidity - disease rate;mortality;multidisciplinary;Muscle;Muscle Cells;Muscle Fibers;Muscle function;Myositis;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Natural History;NF-kappa B;novel;novel therapeutics;Onset of illness;Outcome;Outcome Assessment;Outcome Measure;Pathogenesis;Patient Outcomes Assessments;Patients;Pattern;PDE 3B;Performance;peripheral blood;Physicians;Polymyositis;prevent;Prevention;Prevention strategy;Preventive Clinical Trial;Preventive therapy;Probability;protective factors;prototype;Randomized Controlled Clinical Trials;Refractory;Rehabilitation therapy;Reporting;Research;Research Personnel;research study;Resources;response;Rheumatism;Rheumatology;Risk Factors;rituximab;Screening for cancer;screening guidelines;Signal Transduction;sodium thiosulfate;Specialist;Sphingomyelinase;Standardization;standardize measure;Stratification;Subgroup;success;Surveys;Symptoms;Syndrome;systemic autoimmune disease;Testing;Therapeutic;Therapeutic Agents;Therapeutic Clinical Trial;Therapeutic Trials;tool;treatment response;treatment trial;Uncertainty;Washington;web site;Weight;Work;X-Ray Computed Tomography;X-Ray Medical Imaging

PROJECT_TITLE: Assessment, Therapy and Prevention Of Autoimmune Disease


NIH_SPENDING_CATS: Endocrine Disruptors;Pediatric;Pregnancy;Prevention;Women's Health Research

PI_NAMEs: FERGUSON, KELLY  (contact)

PROJECT_TERMS: Accidents;Address;Affect;Aliquot;Animals;Behavior;Biological;Biological Markers;Birth;bisphenol A;California;Cardiac;Chemicals;Child;Child Development;Childhood;Cognition;cohort;Cohort Studies;Collaborations;Collection;Communities;Data;Databases;Developed Countries;Development;early childhood;early life exposure;early pregnancy;Embryo;Enrollment;environmental chemical exposure;Environmental Impact;Environmental Pollutants;epidemiologic data;Epidemiology;Event;Exposure to;fetal;Fetal Development;Fetal Growth;Fetus;First Pregnancy Trimester;Freezing;Generations;Genetic;Goals;Growth;Health;health care service utilization;Human;Impairment;Inflammation;interest;Laboratories;late life;Life;man;Measures;Mediator;Medical;Medical center;metabolomics;Mothers;multidisciplinary;National Health and Nutrition Examination Survey;National Institute of Environmental Health Sciences;Netherlands;neurodevelopment;Norway;offspring;Organogenesis;Organophosphates;Outcome;Outcome Assessment;Oxidative Stress;Paper;pesticide exposure;Pesticides;phthalates;Plasma;Polypropylenes;Population;Predisposition;Pregnancy;Pregnancy Outcome;Pregnant Women;prenatal;Prospective Studies;psychologic;Publishing;Reporting;Research;Research Personnel;Resources;Sampling;Specimen;Spottings;Standardization;Statistical Data Interpretation;Testing;Third Pregnancy Trimester;ultrasound;Umbilical Cord Blood;Urine;Woman;Xenobiotics;young adult

PROJECT_TITLE: The Generation R cohort study as an NIEHS resource


NIH_SPENDING_CATS: Cancer;Complementary and Integrative Health;Diabetes;Digestive Diseases;Genetics;Liver Disease;Nutrition

PROJECT_TERMS: Adult;Agonist;anti-cancer;Anti-Inflammatory Agents;Asthma;Autoimmune Diseases;Cell Physiology;Cholecalciferol;Complex;Development;Diabetes Mellitus;diabetes risk;differential expression;Disease;Embryonic Development;Exhibits;Fatty Liver;Fibrosis;gene environment interaction;Gene Expression;Genes;Genetic Transcription;High Fat Diet;Human Pathology;IL17 gene;Immune response;Immune system;immunoregulation;Inflammation;Inflammatory;Inflammatory Response;Knockout Mice;Laboratories;Ligands;Link;Lipids;Liver;Malignant Neoplasms;MAP3K7 gene;Mediating;Mediator;Melanoma;member;Metabolic Pathway;Metabolic syndrome;Metabolism;Mus;novel therapeutic intervention;NR4A2 gene;Nuclear Receptors;Orphan;Pathology;Pathway Analysis;Phenotype;Physiological;Physiological Processes;Play;Predisposition;promoter;Property;Proteins;Psoriasis;receptor;receptor expression;Regulation;Retinoids;Role;RXR;Series;Signal Pathway;Therapeutic;therapeutic target;transcription factor;Transcriptional Activation;transcriptome sequencing;Variant;Vitamin D

PROJECT_TITLE: Nuclear receptors: action, functions, and roles in disease


NIH_SPENDING_CATS: Genetics;Prevention

PROJECT_TITLE: Structure-function studies on Dgt triphosphohydrolase


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Nutrition;Obesity;Prevention

PI_NAMEs: WADE, PAUL A (contact)

PROJECT_TERMS: Animal Model;Animals;Area;base;Base Sequence;Basic Science;Binding;Binding Sites;Biological;biological systems;Breast Cancer Cell;Calories;Catalogs;Cells;Chromatin;chromatin modification;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Colon;colorectal cancer risk;Data Analyses;Deposition;Development;Diagnostic;Diet;disorder risk;Dissection;DNA;DNA Modification Process;DNA Repair;Enhancers;Environment;Environmental Risk Factor;Enzymes;Epigenetic Process;epigenetic regulation;Epithelial Cells;Epithelium;Eukaryotic Cell;experimental study;Fatty acid glycerol esters;GATA3 gene;Gene Activation;Gene Expression;Gene Expression Regulation;Generations;Genes;genetic information;Genetic Screening;Genetic Transcription;Genome;Goals;Health;Human;improved;interest;Invaded;Kinetics;Laboratories;Laboratory Study;Maps;Mesenchymal;microbiome;Mission;mouse model;Mus;National Institute of Environmental Health Sciences;Nucleosomes;Obesity;Phenotype;Polymers;Positioning Attribute;Process;Productivity;programs;Proteins;recombinational repair;Regulation;Research;Role;System;Technology;Testing;Therapeutic;Thinness;Tissues;transcription factor;Transcriptional Regulation;transcriptome;tumor;tumor progression;Work;Zinc Fingers

PROJECT_TITLE: Eukaryotic Transcriptional Regulation


PI_NAMEs: FESSLER, MICHAEL B (contact)

PROJECT_TERMS: 2019-nCoV;25-hydroxycholesterol;Alabama;allergen Bla g 1;Alveolar Macrophages;American;Annual Reports;Apoptotic;Area;Bacteria;Biological Models;Biology;Cell Physiology;Cells;Cellular biology;Cholesterol;cockroach allergen;cytokine;Dendritic Cells;Disease;Epithelial Cells;Failure;flotillin;General Hospitals;Goals;Granulocyte Colony-Stimulating Factor;Granulocyte-Macrophage Colony-Stimulating Factor;Host Defense;immunodeficiency;In Vitro;in vivo Model;Inflammation;Inflammatory Response;Inhalation;Innate Immune Response;Interferon Type I;Intramural Research;Investigation;Israel;Journals;Laboratories;Leukocytes;Lipopolysaccharides;Lung;Macrophage;Massachusetts;Mediating;Medical center;Membrane;Membrane Proteins;Metabolism;Modeling;Molecular;Molecular Biology;monocyte;Mus;National Institute of Environmental Health Sciences;Natural Immunity;neutrophil;novel;oxidized low density lipoprotein;Ozone;Paper;pathogen;Pathogenesis;Pathway interactions;Pattern;Pneumonia;Printing;programs;Proteins;Proteomics;Publications;Receptor Signaling;Regulation;Reporting;respiratory;Role;Signal Pathway;Signal Transduction;Smith-Lemli-Opitz Syndrome;Sterols;Stimulus;symposium;T cell regulation;T-Cell Receptor;T-Lymphocyte;Tissues;Toll-like receptors;TP53 gene;trafficking;Tumor Immunity;Universities;Validation;Visit

PROJECT_TITLE: Cell Signaling of Host Defense


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Prevention;Women's Health Research

PROJECT_TERMS: Acceleration;Affect;Age;anti-depressive agents;Biological Aging;Biological Markers;Blood;Blood specimen;Body mass index;breast cancer diagnosis;Breast Cancer Risk Factor;Breast Cancer Treatment;Calibration;Cancer Etiology;Cancer Prognosis;cell type;Clip;cohort;Cohort Studies;Collaborations;college;Computer Assisted;Data;de novo mutation;Diabetes Mellitus;Diagnosis;Disease;DNA;Endometrial Carcinoma;Enrollment;Environmental Risk Factor;Epidemiology;epidemiology study;experience;Family;family structure;follow-up;Funding;Future;Genetic;genetic analysis;Genetic study;Genitalia;genome analysis;Genotype;Gestational Diabetes;Goals;Health;Health Status;Hematopoietic Neoplasms;Hispanic Populations;Home visitation;In Situ;Incidence;interest;Iron;Joints;Leukocytes;Life Style;male;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Measures;Medical Records;member;Mental Depression;Metals;Methods;Methylation;methylation pattern;methylome;Microchimerism;National Institute of Environmental Health Sciences;Nature;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Obesity;Outcome;Paper;Parents;Participant;Performance;Perimenopause;personal care products;Pharmaceutical Preparations;Postdoctoral Fellow;Powder dose form;predictive modeling;Pregnancy Histories;Pregnancy loss;Professional counselor;prospective;Prospective Studies;Publishing;Puerto Rican;Puerto Rico;Questionnaires;Radiation;recruit;Recurrence;Reporting;Research Personnel;Risk;Risk Assessment;Risk Factors;risk prediction;Role;Saliva;Sampling;Seasons;Serum;Sister;Specimen;Structure of nail of toe;summer internship;Survivors;Telephone Interviews;Time;Trace Elements;transcriptome;treatment effect;Tumor Tissue;Urine;Vaginal Douching;Vital Status;Vitamin D;Vitamins;White Women;whole genome;Woman;Work;Y Chromosome

PROJECT_TITLE: The Two Sister Study


NIH_SPENDING_CATS: Asthma;Biotechnology;Climate-Related Exposures and Conditions;Eczema / Atopic Dermatitis;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Human Genome;Lung;Microbiome;Prevention;Rural Health;Tobacco;Tobacco Smoke and Health

PI_NAMEs: LONDON, STEPHANIE  (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;Adult;Agricultural Health Study;airway inflammation;Allergens;Allergic;Allergic Disease;Animals;Asthma;asthmatic;atopy;Biological;Blood;cohort;Cross-Sectional Studies;Data;design;Development;Diagnosis;Diesel Exhaust;Dietary Factors;Disease;Dust;early life exposure;Eczema;Eligibility Determination;Endotoxins;Environment;Environmental Exposure;Environmental Risk Factor;environmental tobacco smoke;Epigenetic Process;epigenome;Exhalation;Exposure to;Farm;farmer;Farming environment;follow-up;Genetic;Genome;genome wide association study;genome-wide;genomic variation;Genomics;Genotype;Geographic Information Systems;Grain;Health;Home;Home visitation;House Dust;Hypersensitivity;IgE;Impairment;Individual;Inflammatory;Inflammatory Response;Innate Immune Response;International;Iowa;late life;Lead;Life;Lipopolysaccharides;Livestock;lung health;Manure;Measurement;Measures;Meta-Analysis;metagenome;Metagenomics;Methylation;microbial;microbial signature;microbiome;microbiota;mortality;multiple omics;Nested Case-Control Study;Nitric Oxide;North Carolina;novel;Occupational Exposure;opioid use;Outcome;Outcome Measure;Participant;Pathway interactions;Patient Self-Report;Pattern;pesticide exposure;Pesticides;Phase;Phenotype;Plasma;Population;population based;proteomic signature;Proteomics;Publications;pulmonary function;Questionnaires;respiratory;respiratory morbidity;response;Risk;Role;Sampling;sex;Single Nucleotide Polymorphism;Sleep Apnea Syndromes;Smoking;smoking exposure;Spouses;Techniques;Technology;Telephone Interviews;Testing;toxicant;Treatment outcome;Wheezing;Work

PROJECT_TITLE: Lung Health Study in the Agricultural Health Study


NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

PI_NAMEs: HU, GUANG  (contact)

PROJECT_TERMS: Animal Model;Candidate Disease Gene;Cell Culture Techniques;Cell model;Cell Reprogramming;Cell Therapy;cell type;Cells;chromatin remodeling;Complex;Cultured Cells;Development;Developmental Biology;developmental toxicity;Disease;disease model;drug discovery;Embryonic Development;embryonic stem cell;Environmental Health;Environmental Risk Factor;Genes;Genetic;genetic approach;Genetic Screening;Genetic Transcription;Genomic approach;genomic tools;Germ Cells;Human Development;human disease;in vitro Model;insight;interest;Maintenance;Modeling;Molecular;Mus;Pathway interactions;pluripotency;pluripotency factor;Pluripotent Stem Cells;Post-Transcriptional Regulation;Resolution;Role;Somatic Cell;Specific qualifier value;stem cell biology;stem cell fate;stem cell self renewal;stem cells;success;translational health science;Translational Research;Work

PROJECT_TITLE: Role of Pluripotency Factors in Pluripotent Stem Cells, Development and Disease


NIH_SPENDING_CATS: Estrogen;Genetics

PI_NAMEs: WILLIAMS, SCOTT  (contact)

PROJECT_TERMS: 3-Dimensional;Acute;Address;Affect;Affinity;APEXL2 Gene;Architecture;base;Base Pairing;Binding;Binding Sites;Biochemical;Biological Models;Biophysics;cancer predisposition;Cell Physiology;Cell Respiration;Chaetomium;Chemicals;Chromatin;Chronic;Complex;coping;Crystallography;cytotoxic;deoxyguanosine triphosphate;Disease;DNA;DNA Adducts;DNA biosynthesis;DNA Damage;DNA glycosylase;DNA Ligases;DNA Ligation;DNA metabolism;DNA Repair;DNA Single Strand Break;DNA strand break;DNA Topoisomerases;DNA-Directed DNA Polymerase;DNA-protein crosslink;environmental stressor;Enzymes;ESR1 gene;Estrogen Therapy;Estrogens;Eukaryotic Cell;Exposure to;Failure;first responder;fungus;Fusion Protein Expression;Gene Expression;Genetic Transcription;Genome;genome integrity;Genomic DNA;genotoxicity;helicase;Heritability;Human;Human Activities;Hybrids;Hydroxyl Radical;improved;In Vitro;in vivo;in vivo Model;Inflammation;inorganic phosphate;Insertion Mutation;Ionizing radiation;Lead;Lesion;Ligase;Ligation;Limb structure;Link;Magnesium;Maintenance;Malignant Neoplasms;Mammalian Cell;Mediating;Methods;milligram;Mismatch Repair;Molecular;Molecular Conformation;molecular recognition;Molecular Structure;Motor;multicatalytic endopeptidase complex;Mutagenesis;Mutation;N-terminal;nanobodies;Neurodegenerative Disorders;Nuclear;nuclease;Nucleic Acids;Nucleotides;Okazaki fragments;Orthologous Gene;paralogous gene;Pathway interactions;Peptide Hydrolases;Pharmaceutical Preparations;Pharmacologic Substance;phosphodiester;preference;prevent;Production;programs;Protein Conformation;Protein Dynamics;Proteins;Protocols documentation;Reaction;Recombinants;Regulation;repaired;Reporter;Reporting;Research;Resolution;response;RNA;RNA analysis;RNA Processing;Role;Saccharomyces cerevisiae;seal;SETX gene;Signal Transduction;Specificity;SPO11 gene;Stress;structural biology;Superhelical DNA;Surveys;System;thermophilic organism;TOP2A gene;Topoisomerase;Topoisomerase II;Toxic Environmental Substances;Transcriptional Regulation;Tyrosine;tyrosyl-DNA phosphodiesterase;Variant;Vertebral column;Wood material;Yeasts

PROJECT_TITLE: Structural Biology of Genome Maintenance and DNA repair


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Food Allergies;Health Effects of Indoor Air Pollution;Immunization;Immunotherapy;Prevention

PI_NAMEs: MUELLER, GEOFFREY  (contact)

PROJECT_TERMS: adaptive immune response;Adverse reactions;Affinity;Albumins;allergen Bla g 1;Allergens;Allergic;Allergic Disease;allergic response;Allergy to peanuts;Anaphylaxis;Antibodies;Antibody Affinity;Antibody Dissociations;Antibody Response;Arachis hypogaea;Area;B-Lymphocytes;Binding;Biological Markers;Blocking Antibodies;Cell Separation;Cellular Membrane;Characteristics;Clinical;clinical efficacy;clinically relevant;cockroach allergen;Complex;cross reactivity;crosslink;cytokine;cytotoxic;Data;Dermatophagoides pteronyssinus antigen p 2;design;Diagnosis;Dictyoptera;Effector Cell;Engineering;Environmental Health;Epitope Mapping;Epitopes;exposed human population;Exposure to;Fatty Acids;flexibility;Future;Generations;Goals;Health;Heat-Shock Proteins 70;Human;Human Cloning;human monoclonal antibodies;Hybridomas;Hydrophobicity;Hypersensitivity;IgE;IgG2;IgG4;Immune response;Immunochemistry;Immunoglobulin G;Immunotherapy;improved;Individual;Inflammatory;interest;Interleukin-1;Knowledge;Ligands;lipid mediator;Lipids;Mammalian Cell;Mediating;Membrane;Membrane Lipids;Modality;Molecular;Molecular Conformation;molecular diagnostics;Molecular Target;Monoclonal Antibodies;Motivation;mouse model;Mutagenesis;mutant;Mutation;National Institute of Environmental Health Sciences;neutralizing monoclonal antibodies;oral immunotherapy;Organism;Outcome;Passive Cutaneous Anaphylaxis;Pathway interactions;Patients;Pattern;Phospholipase A2;Phospholipids;Polyunsaturated Fatty Acids;Predisposition;prevent;Production;Property;Recombinant Antibody;Recombinants;Reporting;Research;Research Personnel;response;Risk Reduction;Sequence Homology;Serum;Site;Source;Structure;Symptoms;Technology;Testing;Therapeutic;Transgenic Mice;Unsaturated Fatty Acids;Viral Physiology;Work;X-Ray Crystallography

PROJECT_TITLE: Molecular Allergy


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Electronic Nicotine Delivery Systems;Prevention;Tobacco

PI_NAMEs: WEINBERG, CLARICE  (contact)

PROJECT_TERMS: Antibodies;Antinuclear Antibodies;Area;Autoantibodies;Autoimmune biomarker;Autoimmune Diseases;Autoimmunity;Biological;Biometry;Collaborations;Data;early pregnancy;Electronic cigarette;follow-up;former smoker;Health Surveys;Link;Measurement;Methodology;Methods;multidisciplinary;National Health and Nutrition Examination Survey;National Institute of Environmental Health Sciences;never smoker;Paper;Population;Postdoctoral Fellow;Prevalence;Publishing;Research;Role;Science;Scientist;Smoker;Surveys;Time;Time trend;Woman;Work;Xenobiotics

PROJECT_TITLE: Applications of methods in collaborative science


NIH_SPENDING_CATS: Genetics

PI_NAMEs: STANLEY, ROBIN  (contact)

PROJECT_TERMS: Amino Acids;Anticodon;Architecture;Base Pairing;Binding;Biochemical;Biochemistry;Cells;Cellular biology;Charge;Complex;Cryoelectron Microscopy;endonuclease;Endoribonucleases;Ensure;Environment;Enzymes;Eukaryota;Excision;Exoribonucleases;fitness;Gene Expression Regulation;Genetic Transcription;Goals;Health;Human;human disease;In Vitro;interdisciplinary approach;Introns;Mediating;Messenger RNA;Methods;Molecular;Mutation;Neurodevelopmental Disorder;nuclease;particle;Pathway interactions;Phosphorylation;Play;Polynucleotide 5'-Hydroxyl-Kinase;Pontocerebellar hypoplasia;Post-Transcriptional RNA Processing;Process;Proteins;reconstitution;recruit;Regulation;Research;response;Ribonucleases;Ribonucleoproteins;Ribosomal RNA;Ribosomes;RNA;RNA Processing;RNA Splicing;Role;rRNA Precursor;Series;stem;Stimulus;structural biology;Structural Models;Structure;Transfer RNA;Translating;Translations;tRNA Precursor

PROJECT_TITLE: Structure and Function of RNA Processing Machines


PI_NAMEs: GORDENIN, DMITRY  (contact)

PROJECT_TERMS: Address;Affect;Alleles;base;Base Excision Repairs;Binding;Biochemical;Bioinformatics;bioinformatics tool;Biological;cancer genome;cancer genomics;cancer initiation;carcinogenesis;Cell Separation;Cells;Chemicals;Chromosomes;Complex;Cytidine Deaminase;Cytosine;Data;Data Set;Defect;design;Development;Disease;DNA;DNA biosynthesis;DNA Damage;DNA polymerase zeta;DNA Repair;DNA Sequence Alteration;DNA Viruses;DNA-Directed DNA Polymerase;Double Strand Break Repair;ds-DNA;empowerment;Environment;Environmental Risk Factor;Eukaryota;experimental study;Exposure to;fitness;Generations;Genes;Genetic;Genetic Diseases;genetic information;Genetic Recombination;Genetic Risk;Genetic Transcription;Genome;genome sequencing;Genome Stability;genome-wide;genomic data;Genomic Instability;Goals;Health;high risk;Human;human genome sequencing;human subject;improved;Individual;Induced Mutation;insight;interest;International;Intervention;Knowledge;Knowledge acquisition;large datasets;Life;life span;Malignant Neoplasms;Metabolic;Mismatch Repair;Modeling;Modification;Molecular;Mutagenesis;Mutagens;Mutation;Mutation Spectra;Natural Immunity;novel;Organism;Outcome;Pathway interactions;Phenotype;Physiological;Policies;power analysis;prevent;Probability;replication factor A;Reporter;Research;Research Subjects;Risk;Risk Factors;RNA;RNA Editing;RNA Sequences;RNA Viruses;Role;Saccharomyces cerevisiae;Saccharomycetales;Sampling;Single-Stranded DNA;Site;Somatic Mutation;Source;synergism;System;The Cancer Genome Atlas;Toxicology;tumor;Uracil;uracil-DNA glycosylase;Variant;Viral;viral RNA;whole genome;Work;Yeast Model System;Yeasts

PROJECT_TITLE: Genome-wide hypermutation and structural instability


PI_NAMEs: CUI, GUOHONG  (contact)

PROJECT_TERMS: Age;age related;alpha synuclein;alternative treatment;Alzheimer's Disease;Anatomy;Basal Ganglia;behavior test;Behavioral;Benomyl;Bilateral;Bioenergetics;biological systems;Brain;brain tissue;Cell Nucleus;Cells;Chronic;Clinical;Cognitive;cognitive function;Corpus striatum structure;Deep Brain Stimulation;Development;Diagnosis;dietary;Disease;disease model;Disease Progression;Dopamine;Dopamine D1 Receptor;dopaminergic neuron;Dose;Dyskinetic syndrome;effective therapy;Energy Metabolism;Environmental Exposure;Etiology;Event;Exercise;Fiber;field study;Frequencies;gamma-Aminobutyric Acid;gene therapy;Genetic;Glutamates;Goals;Health;Home;Hour;Human;improved;Individual;Injections;Intake;L-DOPA induced dyskinesia;Lesion;Levodopa;Measures;mitopark mouse;Molecular;Monitor;Motor;motor deficit;motor function improvement;motor symptom;mouse model;Movement;Movement Disorders;Mus;Nervous System Disorder;neural;Neurodegenerative Disorders;neuromechanism;Neurons;neurotransmitter release;nicotinamide-beta-riboside;novel;novel diagnostics;novel imaging technique;novel strategies;novel therapeutics;Oxidopamine;Parkinson Disease;parkinsonian rodent;pars compacta;Pathology;Patients;Performance;Pharmaceutical Preparations;Photometry;positive allosteric modulator;postsynaptic;presynaptic;Presynaptic Terminals;prevent;protective effect;reduce symptoms;Research;Rotarod Performance Test;Running;sensor;side effect;Sleep;Sleep disturbances;Structure;Structure of subthalamic nucleus;Substantia nigra structure;Supplementation;Survival Rate;Symptoms;Synapses;Techniques;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;Time;Tissue Banks;tool;United States National Institutes of Health;Viral Vector

PROJECT_TITLE: Basal Ganglia in Health and Disease


PI_NAMEs: DEMAYO, FRANCESCO  (contact)

PROJECT_TERMS: Ablation;Adverse effects;Aging;Anti-Inflammatory Agents;Attenuated;Binding Sites;Bioinformatics;Biological Models;Biology;Birth;Body System;cBioPortal;Cell Differentiation process;Cell Physiology;Cell Proliferation;cell stroma;Cells;Cervix Uteri;Child;cofactor;Collagen;Communication;cytokine;cytokine release syndrome;Data Collection;Data Set;Decidual Cell;Decidual Cell Reactions;Development;Diet;dihydroxy-vitamin D3;Down-Regulation;early pregnancy;Endocrine Disruptors;Endometrial;Endometrial Carcinoma;endometrial stroma;Endometrial Stromal Cell;endometriosis;Endometrium;Enhancers;Environment;Environmental Impact;epidemiology study;Epithelium;ESR1 gene;Estrogen Therapy;Estrogens;Exhibits;Exposure to;Failure;Female;female reproductive system;female reproductive tract;Female sterility;Fertility;Fertilization;Fetal Development;Fetus;Fibroblasts;Fibrosis;Gene Expression;Genes;genetic signature;Genetic Transcription;Genetically Engineered Mouse;Gland;Goals;Growth;Health;health of the mother;Hormonal;hormonal signals;Hormones;Human;Human Cell Line;human model;Impairment;implantation;In Vitro;Infant;Infertility;Inflammation;Inflammatory;Investigation;knock-down;Laboratories;Maintenance;Mammalian Oviducts;Mediating;Mediator;Menstrual cycle;Microfilaments;Modeling;Molecular;Mothers;mouse model;Mus;Muscle Development;Mutation;myometrium;natural Blastocyst Implantation;neonatal health;novel;Nuclear Receptors;Organ;Ovarian;Ovariectomy;Pathology;Pathway interactions;Physiology;Pregnancy;pregnant;preimplantation;prevent;Process;Progesterone;Progesterone Receptors;programs;Proliferating;pup;Reaction;receptor;Regulation;Regulator Genes;Reporting;Reproduction;Reproductive Biology;reproductive function;reproductive system disorder;reproductive tract;Research;response;RNA Interference;Role;Serum Response Factor;Signal Pathway;Signal Transduction;sperm cell;steroid hormone;steroid hormone receptor;Stimulus;Stream;Stretching;Structure;success;The Cancer Genome Atlas;Tissues;transcription factor;transcriptome;transcriptomics;Uterine Diseases;Uterine Fibroids;Uterine Neoplasms;Uterus;Vagina;Vitamin D;Vitamin D Deficiency;Vitamin D3 Receptor;Vitamins;Woman;Women's Health;women's reproductive health;Work;Zinc Fingers

PROJECT_TITLE: Environmental Signaling in Reproduction and Pregnancy


NIH_SPENDING_CATS: Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PROJECT_TERMS: 37 weeks gestation;Address;adverse birth outcomes;adverse pregnancy outcome;age group;Aromatic Polycyclic Hydrocarbons;Biological Markers;Birth;Blood;Boston;case control;Chemical Exposure;Chemicals;Child Health;Childhood;cohort;Collaborations;consumer product;Data;Data Pooling;Disparity;early pregnancy;environmental chemical exposure;Environmental Exposure;Environmental Pollutants;Esters;ethnic disparity;Etiology;fatty acid oxidation;Fetal Diseases;Fetal Growth;Fetal Growth Retardation;Flame Retardants;Gestational Age;Growth;Growth Disorders;Health;Histology;Hospitals;improved;Individual;Inflammation;Inflammatory;innovation;insight;Investigation;lipidomics;Measurement;Measures;Mediating;Mediator;Metabolic;metabolomics;Metal exposure;Metals;Methods;National Institute of Environmental Health Sciences;Newborn Infant;novel;Organophosphates;Outcome;Oxidative Stress;Oxidative Stress Pathway;Paper;Participant;Pesticides;Phenols;Phenotype;phthalates;Pilot Projects;Placenta;Plasticizers;Poly-fluoroalkyl substances;Population Characteristics;Pregnancy;pregnancy health;Pregnancy Trimesters;Premature Birth;Preparation;prepregnancy;Prevention;Production;programs;prospective;Publications;Publishing;racial disparity;Reactive Oxygen Species;Research;Research Personnel;Research Project Grants;Resources;Small for Gestational Age Infant;Specimen;study characteristics;Third Pregnancy Trimester;Time;Trace metal;ultrasound;urinary;Urine;Woman

PROJECT_TITLE: LIFECODES pregnancy cohort


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Cystic Fibrosis;Genetics;Human Genome;Infectious Diseases;Lung;Rare Diseases

PI_NAMEs: DOETSCH, PAUL  (contact)

PROJECT_TERMS: acquired drug resistance;acute infection;Address;Agar;Aging;Amino Acyl-tRNA Synthetases;Antibiotic Resistance;Antineoplastic Agents;Antioxidants;bacterial resistance;base;Base Excision Repairs;biological adaptation to stress;Biological Markers;bronchial epithelium;cancer genome;cancer genomics;Cancer Patient;cell transformation;Cells;Cessation of life;Chronic;Cipro;Cisplatin;Clinical;clinically relevant;Code;Complex;Contact Inhibition;cystic fibrosis infection;cystic fibrosis patients;Detection;Development;Dideoxy Chain Termination DNA Sequencing;Dimensions;DNA;DNA Damage;DNA Gyrase;DNA Repair Gene;DNA Repair Pathway;Dose;Drug resistance;Environment;Epithelial Cells;Exhibits;Exposure to;Frequencies;Generations;Genes;Genetic Transcription;genome sequencing;genomic data;Genomic Instability;Glutathione;Goals;Growth;Heterogeneity;homologous recombination;Hospitalization;Human;human disease;Hydrogen Peroxide;Hypochlorous Acid;Immune system;Individual;loss of function mutation;Lung infections;Malignant Neoplasms;Maps;Metabolic;Molecular Analysis;Multi-Drug Resistance;Mutagenesis;mutant;Mutation;Mutation Spectra;Nature;neoplastic cell;novel;Outcome;overexpression;Oxidants;Oxidation-Reduction;Paraquat;pathogen;pathogenic bacteria;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;Phenotype;Pneumonia;potassium bromate;Process;Proteins;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Reaction;Reactive Oxygen Species;repaired;replication stress;Resistance;response;S-Nitrosoglutathione;Signal Transduction;Single-Stranded DNA;Spottings;Stress;Sulfhydryl Compounds;System;Therapeutic;Tissues;Toxic effect;tumor;Tumor Suppressor Proteins;United States;Up-Regulation;whole genome;XPGC protein;Yeasts

PROJECT_TITLE: Mechanisms of transcriptional and replicative mutagenesis


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases

PROJECT_TERMS: 2019-nCoV;Active Sites;antiviral drug development;base;Binding;Biochemistry;biophysical techniques;Coronavirus;COVID-19;COVID-19 therapeutics;Cryoelectron Microscopy;Development;Double-Stranded RNA;Drug Targeting;Endoribonucleases;global health;Goals;Immune response;Interferons;Life Cycle Stages;Mass Spectrum Analysis;Molecular;Molecular Conformation;molecular dynamics;Nonstructural Protein;novel strategies;novel therapeutics;nuclease;Pancreatic ribonuclease;pandemic disease;Play;Process;Proteins;Reaction;response;RNA;Role;sensor;Specificity;structural biology;Structure;Uracil;Uridine;Vaccines;Viral;Viral Genome;viral RNA;Virus;Work

PROJECT_TITLE: Structural and Functional Characterization of the SARS-CoV-2 Endoribonuclease Nsp15


NIH_SPENDING_CATS: Biomedical Imaging;Endocrine Disruptors;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

PROJECT_TERMS: 3D ultrasound;Adult;adverse outcome;adverse pregnancy outcome;Angiogenic Factor;Arteries;Assessment tool;Biological Markers;Biometry;Birth Weight;Blood flow;Breast Microcalcification;Chemical Exposure;Chemicals;Child;circulating biomarkers;cohort;Collaborations;Data;Disease;environmental chemical exposure;Exposure to;fetal;Fetal Growth;Fetal Growth Retardation;Fetus;Functional disorder;Funding;Funding Mechanisms;Future;Goals;Growth;Health;health assessment;heart function;Human;Image;implantation;improved;in utero;in vivo;Infarction;innovation;Lead;Measurement;Measures;Methodology;molecular marker;Motion;National Institute of Child Health and Human Development;Neonatal Mortality;novel;Nutrient;Organ;Outcome;Oxygen;Participant;Pathologic;Perfusion;phthalates;Placenta;Placentation;Pregnancy;pregnant;prenatal exposure;Publishing;recruit;Research;Resolution;Risk Factors;Role;Sampling;Specimen;Spottings;stillbirth;Structure of umbilical artery;Technology;Three-Dimensional Imaging;Time;Tissues;ultrasound;Umbilical Blood;urinary;Urine;Uterus;Variant;Visit;Weight;Woman;Work

PROJECT_TITLE: Environmental phthalate exposure in the Human Placenta Project cohort


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Tobacco;Tobacco Smoke and Health;Vaccine Related

PROJECT_TERMS: 2019-nCoV;Antibodies;Antibody Response;Blood specimen;CD8-Positive T-Lymphocytes;cell type;COVID-19;COVID-19 incidence;COVID-19 morbidity;COVID-19 pandemic;COVID-19 vaccination;Cryopreservation;Data;Disease;FCGR3B gene;Frequencies;high risk;Immune;Immune System Diseases;immunosenescence;Individual;Morbidity - disease rate;mortality;non-smoker;Peripheral Blood Mononuclear Cell;post-COVID-19;Predisposition;Premature aging syndrome;prospective;Regulatory T-Lymphocyte;sample collection;Sampling;SARS-CoV-2 antibody;SARS-CoV-2 exposure;SARS-CoV-2 infection;SARS-CoV-2 negative;senescence;single-cell RNA sequencing;Smoker;Smoking;smoking exposure;T-Lymphocyte Subsets;Vaccinated;Vaccination;Vaccines;Visit;volunteer

PROJECT_TITLE: SARS-CoV-2 Studies


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Lung

PROJECT_TERMS: 2019-nCoV;25-hydroxycholesterol;Address;airway epithelium;Albumins;antagonist;Anti-Inflammatory Agents;Biological Assay;Body Weight decreased;Cell fusion;Cells;Cholesterol;Communicable Diseases;Coronavirus;COVID-19;COVID-19 pneumonia;COVID-19 therapeutics;cytokine;Disease;enantiomer;Enzymes;Epithelial Cells;Experimental Models;Family suidae;G-Protein-Coupled Receptors;global health emergency;Histopathology;Human;in vivo;Infection;innovation;International;Investigation;Knockout Mice;Leukocytes;Lipids;Lung;Lung immune response;Lung infections;lung injury;Macaca mulatta;Measures;Metabolism;migration;Mixed Function Oxygenases;mouse model;Mus;Organoids;Pathogenicity;Plasma;Porcine respiratory and reproductive syndrome virus;preclinical safety;Publishing;rapid testing;Reporter;Respiratory Tract Infections;response;SARS-CoV-2 B.1.351;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;Series;Testing;Therapeutic;therapeutic evaluation;tool;Toxic effect;Transgenic Mice;Viral;Viral Load result;Virion;Virus;Virus Diseases;virus testing;Wild Type Mouse;Work;Zika Virus

PROJECT_TITLE: Investigation of the therapeutic potential of oxysterols in SARS-CoV-2 infection


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Cardiovascular;Clinical Research;Diabetes;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: ROTIMI, CHARLES  (contact)

PROJECT_TERMS: Adipocytes;adiponectin;Adipose tissue;Africa;African;African American;African American population;Alcohol consumption;analytical tool;Attention;bead chip;Biological;Biological Markers;Biological Process;Blood;blood lipid;Blood Pressure;Blood specimen;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;cell type;Cholesterol;Chromatin;Chromosome Mapping;Clinical;clinical care;cohort;Complex;Congresses;CRISPR/Cas technology;Data;Dedications;Developing Countries;Diabetes Mellitus;Disease;Disease susceptibility;disparity elimination;disparity reduction;DNA analysis;DNA Methylation;Endothelial Cells;Enteroendocrine Cell;Environmental Risk Factor;epidemiologic data;epidemiological model;epigenome-wide association studies;ethnic difference;ethnic diversity;Ethnic Origin;Ethnic Population;Etiology;European;European ancestry;Family Study;fasting glucose;Functional disorder;functional genomics;G6PC2 gene;Gene Frequency;Genes;Genetic;genetic epidemiology;Genetic Models;Genetic Risk;Genetic study;Genetic Variation;Genome;genome resource;genome sciences;genome sequencing;genome wide association study;genome-wide;Genomic approach;genomic data;Genomics;global health;Gluconeogenesis;Glucose;Glycolysis;Goals;Health;health disparity;health inequalities;High Density Lipoprotein Cholesterol;High Density Lipoproteins;Home;Human;Human Genetics;Human Genome;Human papilloma virus infection;Hypertension;improved;Individual;insight;Insulin Resistance;insulin secretion;International;Islets of Langerhans;Joints;Kidney Diseases;Knowledge;LDL Cholesterol Lipoproteins;Least-Squares Analysis;Life Style;Lipids;Liver;Longitudinal Studies;Low-Density Lipoproteins;men;Mendelian randomization;Metabolic Diseases;metabolomics;Methylation;methylation pattern;Migrant;Mission;Modeling;molecular phenotype;multi-ethnic;multiple omics;Nigeria;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;obese person;Obesity;Overweight;Paper;Participant;Pathogenesis;Pathway interactions;Pattern;Pharmaceutical Preparations;Phenotype;Physical activity;Plasma;Play;Policies;polygenic risk score;Population;Population Heterogeneity;Positioning Attribute;Postdoctoral Fellow;Predisposition;programs;Proteomics;Protocols documentation;Publishing;Reporting;Research;Research Personnel;Resources;response;Risk;Risk Factors;risk variant;Role;Sampling;Science;Scientist;sedentary lifestyle;Services;Signal Transduction;single nucleus RNA-sequencing;Skeletal Muscle;Smoking;social culture;South Africa;Stroke;Students;Tissue Banks;Tissues;Training;Training Programs;trait;transcriptome sequencing;transcriptomics;Translating;Triglycerides;United States National Institutes of Health;Universities;Untranslated RNA;Variant;Weight;whole genome;Work;working group

PROJECT_TITLE: Genetic epidemiology of complex diseases


ACTIVITY: ZIB

ORG_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

PI_NAMEs: THOMAS, JAMES  (contact)

PROJECT_TERMS: Accounting;Adoption;analysis pipeline;Animals;Basic Science;Biological Sciences;Biology;Cells;ChIP-seq;clinical center;Clinical Sciences;Clinical Trials;Collaborations;comparative;complex data;Computer software;cost;Data;Data Analyses;Data Set;Dedications;design;Development;DNA;DNA sequencing;exome sequencing;Future;Genome;genome sequencing;genome-wide;Goals;Human;Human Genome;Informatics;Infrastructure;interest;Intramural Research Program;Laboratories;Management Information Systems;Medicine;meetings;member;Methods;microbiome research;Monitor;nanopore;National Human Genome Research Institute;National Institute of Allergy and Infectious Disease;novel;Patients;Positioning Attribute;Production;programs;Protocols documentation;Publications;Research;Research Personnel;Role;Sampling;SARS-CoV-2 genome;secondary analysis;sequencing platform;skin microbiome;System;Talents;targeted sequencing;Technology;telomere;Testing;transcriptome sequencing;transcriptomics;United States National Institutes of Health;whole genome;Work

PROJECT_TITLE: Inter- and Intra-Species Comparative Sequencing


ACTIVITY: ZIC

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: PLATT, MANU  (contact)

PROJECT_TERMS: 3D Print;Acceleration;Active Learning;Address;Area;Artificial Intelligence;Baltimore;Biocompatible Materials;Biomechanics;Biomedical Engineering;biomedical imaging;Biosensing Techniques;Clinical;clinical center;clinical translation;Code;Collaborations;college;Communities;community building;community center;Computer software;computing resources;Consultations;Country;Databases;Development;Devices;Discipline;Educational workshop;Eligibility Determination;Engineering;Environment;Equipment;equity, diversity, and inclusion;Event;Extramural Activities;fabrication;Fostering;Funding;Goals;graduate student;help-seeking behavior;Human Resources;Image;Informatics;instrument;instrumentation;Interdisciplinary Study;interest;Internships;Intramural Research;Intramural Research Program;Laboratories;Laboratory Research;Language;Lasers;Licensing;Linux;machine learning framework;Maintenance;meetings;Microscope;Mission;Modeling;multi-photon;nano;National Institute of Biomedical Imaging and Bioengineering;novel;Occupations;open source;Participant;Persons;physical science;Postbaccalaureate;Postdoctoral Fellow;posters;preservation;Process;Professional Competence;Programming Languages;programs;prospective;Pythons;recruit;repaired;Research;Research Personnel;Resources;Running;Schedule;Science;Scientist;Series;shared memory;simulation;skills;Societies;square foot;Staging;summer internship;symposium;synthetic biology;Systems Biology;Talents;Techniques;Technology;Testing;Time;tool;Training and Education;training opportunity;Training Programs;Translational Research;undergraduate student;United States;United States National Institutes of Health;Universities;Update;user-friendly;Visualization;Work

PROJECT_TITLE: Center for Biomedical Engineering Technology Acceleration (BETA Center)


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Genetics;Primary Immunodeficiencies;Rare Diseases

PI_NAMEs: COPELAND, WILLIAM  (contact)

PROJECT_TERMS: 5'-deoxyribose phosphate lyase;Active Sites;Affect;Allergens;Androgen Receptor;Area;Attention;Binding;biological systems;Classical Mechanics;computational chemistry;Computers;computing resources;cost;CYP2J2 gene;dGTPase;Dimerization;Diphosphates;DNA;DNA Damage;DNA Structure;DNA-Directed DNA Polymerase;Docking;Double Strand Break Repair;drug-like compound;Estrogen Receptors;Evaluation;functional hypothalamic amenorrhea;Goals;Health;Human;improved;interest;Ions;Juvenile Dermatomyositis;Ligand Binding;Lipids;Measures;Mechanics;Memory;Metals;Methodology;Methods;Modeling;Molecular Analysis;Molecular Conformation;molecular dynamics;molecular mechanics;molecular modeling;Muscle;mutant;Mutation;N-terminal;nanosecond;National Institute of Environmental Health Sciences;Nucleotides;peptide structure;Peptides;Phosphopeptides;Polyglandular Autoimmune Syndrome Type I;Procedures;Process;Proteins;quantum;Quantum Mechanics;Reaction;Research;Research Personnel;Resort;Ribonucleotides;RNA;RNA Binding;RNA Degradation;RNA Splicing;Role;Running;Sampling;SARS-CoV-2 spike protein;Scheme;Scientist;simulation;small molecule;Structural Protein;Structure;Sum;Syndrome;System;Technology;Testing;tool;Translating;Validation;Variant;Work;Writing

PROJECT_TITLE: Computational Chemistry and Macromolecular Modeling


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases

PI_NAMEs: RAY, MANAS  (contact)

PROJECT_TERMS: 2019-nCoV;Adopted;Alleles;Amino Acids;animal facility;Animal Husbandry;Animal Model;Animals;Annual Reports;Breeding;Budgets;Cell Line;Cell Separation;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collaborations;Communities;Complex;conditional knockout;cost;Cost Savings;COVID-19;CRISPR/Cas technology;Cryopreservation;design;Disease;early embryonic stage;Electroporation;Embryo;embryo cell;embryo cryopreservation;Embryo Transfer;embryonic stem cell;Engineering;Event;Exons;experimental study;Extramural Activities;Face;Female;Fertilization in Vitro;Flow Cytometry;Fluorescence;Fostering;Future;gene editing technology;gene function;Gene Modified;Genes;genetically modified cells;Genome;genome editing;Genotype;Germ Lines;Glucocorticoid Receptor;Goals;Guide RNA;Heterozygote;homologous recombination;human coronavirus;human disease;improved;In Vitro;in vivo;Individual;Injections;Journals;Knock-out;Logistics;Manuscripts;meetings;member;Microinjections;Mission;Molecular;monolayer;Morphology;Mothers;mouse genome;mouse model;Mus;mutant;mutant mouse model;Mutant Strains Mice;Mutate;Mutation;National Institute of Environmental Health Sciences;Non-Commercial Sources;novel;novel coronavirus;Orphan;Ovum;payment;Peer Review;Phenotype;Play;Point Mutation;Population;preservation;Process;Production;PTGS2 gene;Publishing;Reagent;recombinase-mediated cassette exchange;Regulation;repaired;Research;Research Personnel;Research Project Grants;Research Support;Resources;RNA;Role;SARS coronavirus;Savings;screening;Services;Severe Acute Respiratory Syndrome;Signal Pathway;Site;Source;sperm cell;sperm cryopreservation;Stress;success;System;Techniques;Technology;Time;tool;Transfection;Transgenes;Transgenic Mice;vector;Vendor;wasting;Work

PROJECT_TITLE: NIEHS Gene Editing and Mouse Model (GEMM) Core Annual Report


NIH_SPENDING_CATS: Genetics;Kidney Disease

PI_NAMEs: WILLIAMS, JASON  (contact)

PROJECT_TERMS: 2019-nCoV;Acetylation;Acetyltransferase;Affect;Albumins;alpha 1-Antitrypsin;alpha-1-microglobulin;Amino Acids;Architecture;Autophagocytosis;Base Excision Repairs;Binding;Bleomycin;Cellular biology;Chemicals;Chimeric Proteins;Collaborations;Complex;Coupled;Cross-Linking Reagents;crosslink;Cryoelectron Microscopy;Deacetylase;Deposition;Development;Digestion;Disease;Dissociation;disulfide bond;DNA Repair Gene;E1A-associated p300 protein;Elements;Enzymes;EP300 gene;Evaluation;Event;experimental study;Fibroblasts;Functional disorder;Gel;Gene Expression;Glomerulonephritis;glycosylation;IGA Glomerulonephritis;IgA1;Immunoglobulin A;In Vitro;insight;Intramural Research;Kidney Diseases;Label;Laboratories;Life Cycle Stages;Link;lipidomics;Lung;Lysine;Malignant Neoplasms;mass spectrometer;Mass Spectrum Analysis;Mediating;Methylation;Minnesota;Modification;Molecular;molecular mass;Molecular Structure;Mus;Nature;Normal Cell;overexpression;Pathogenesis;Patients;Peptide Hydrolases;Peptides;Phosphorylation;Plasma Proteins;Platelet-Derived Growth Factor alpha Receptor;Polymerase;Polymers;Post-Translational Protein Processing;Preparation;Prevention;Principal Investigator;protein aggregation;protein complex;protein crosslink;protein expression;protein structure;Proteins;Proteome;Proteomics;Radiolabeled;ran GTP-Binding Protein;Reducing Agents;Renal Hypertension;Research;Research Project Grants;Resolution;RNA Splicing;Robin bird;Role;Sampling;Scientist;Services;Side;Signal Transduction Pathway;Site;small molecule;small molecule inhibitor;structural biology;Structure;Structure of glomerular mesangium;Sulfur;Support Groups;System;Techniques;thioether;Toxicology;Transfer RNA;Transferase;Trypsin;Ubiquitination;Universities;Variant;Western Blotting;Work

PROJECT_TITLE: Mass Spectrometry Identification


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

PI_NAMEs: WADE, PAUL A (contact)

PROJECT_TERMS: ATAC-seq;Cell Separation;ChIP-seq;Chromium;Communities;Consultations;Cost Savings;Custom;Data;Data Analyses;Disease;DNA;DNA sequencing;DNA Sequencing Facility;epigenomics;Experimental Designs;Genetic Predisposition to Disease;Genomics;Individual;Instruction;instrumentation;Investigation;Libraries;Methods;National Institute of Environmental Health Sciences;next generation sequencing;Outcome;Preparation;Process;Research;Research Personnel;Sampling;Scientist;Services;single cell analysis;single cell sequencing;single-cell RNA sequencing;System;targeted sequencing;theories;Training;transcriptome sequencing

PROJECT_TITLE: Epigenomics and DNA Sequencing


NIH_SPENDING_CATS: Infectious Diseases;Orphan Drug;Rare Diseases

PI_NAMEs: PEDERSEN, LARS  (contact)

PROJECT_TERMS: Active Sites;Affinity;Allergens;Allergic;Alveolar Bone Loss;Anabolism;Anaphylaxis;Antibodies;Antibody Binding Sites;Apoptotic;Area;Behavior;Binding;Binding Sites;Biogenesis;biological systems;Biology;Bone remodeling;Bone Resorption;Breast;C-terminal;Caspase;Catalysis;cathepsin K;Cell surface;Chondroitin Sulfates;clinically relevant;Coagulation Process;Collaborations;collagenase;Communities;cross reactivity;Cryoelectron Microscopy;Crystallization;Crystallography;Cysteine Proteinase Inhibitors;design and construction;dimer;Dimerization;Disease;enzyme biosynthesis;Enzymes;Epitopes;Excision;flexibility;Foundations;Glucosamine;Glucuronic Acids;Glucuronosyltransferase;Goals;Head;Health;Heparin;Heparitin Sulfate;heparosan synthase;Human;Hypersensitivity;IgE;IgG4;Immune response;Immunotherapy;improved;Individual;Induction of Apoptosis;Industrialization;Inflammation;inhibitor;insight;interest;Location;Macromolecular Complexes;Malignant Neoplasms;Modeling;Molecular Conformation;Molecular Structure;mouse model;Multiple Myeloma;Mus;mutant;Mutate;National Institute of Environmental Health Sciences;neutralizing antibody;novel;Oligosaccharides;Osteoclasts;Osteoporosis;Paget's Disease;Passive Cutaneous Anaphylaxis;Pasteurella multocida;Patients;Peptide Hydrolases;Play;post gamma-globulins;potential biomarker;Process;Production;Property;protein complex;protein function;Proteins;Protomer;Publishing;Reaction;receptor;Research;Research Personnel;research study;Research Support;Resolution;response;Rheumatoid Arthritis;Ribosomes;Risk Reduction;Roentgen Rays;Role;scale up;Scientist;Serum;side effect;Site;Structure;Substrate Specificity;success;Sulfate;Surface;Tail;targeted treatment;Techniques;Therapeutic;Tissues;TNF-related apoptosis-inducing ligand;TNFSF10 gene;tumor;Universities;Virus Diseases;Work;X-Ray Crystallography

PROJECT_TITLE: Crystallographic studies of macromolecular structures


PROJECT_TERMS: Acrylamides;Adenosine;Adopted;Adrenalectomy;Aging;Animals;Area;Area Under Curve;Beds;Bile Acids;Biological;Biological Assay;Bleomycin;Blood Platelets;Brain;cardiovascular health;cell injury;cell type;Cells;Chromatography;Circulation;cofactor;Collaborations;comparative;Computer software;Consumption;cost efficient;Custom;Data;data acquisition;deprivation;Development;Dexamethasone;Diet;Disease;DNA;DNA Repair;dosage;Dryness;Eicosanoids;Environment;Environmental Exposure;Estrus;Evaluation;experimental study;exposure to cigarette smoke;Extramural Activities;Fatty Acids;Fibroblasts;Goals;Harvest;Human;Immunoglobulin A;improved;Individual;Inflammation;Injections;Ions;Isomerism;knockout gene;Knockout Mice;Label;Laboratories;lipidomics;Lipids;Liquid Chromatography;liquid chromatography mass spectrometry;Liquid substance;Liver;London;Lung;manufacture;Mass Spectrum Analysis;Measurement;Measures;mesangial cell;Metabolic;Metabolism;Methionine;method development;Methods;mouse model;Mus;National Institute of Environmental Health Sciences;Nature;Neurons;novel;Nucleosides;Onset of illness;Output;Parkinson Disease;Pathology;Patients;Pentas;Peptides;Phosphorylation;Plasma;Plasma Proteins;Platelet-Derived Growth Factor alpha Receptor;Play;Preparation;Protein Analysis;protein complex;protein expression;Proteins;Proteome;Proteomics;Protocols documentation;Publications;Reaction;Reagent;Recommendation;Research Personnel;Research Project Grants;Ribonucleosides;Ritalin;Role;Running;Sampling;Scanning;Science;Signaling Molecule;Source;Stable Isotope Labeling;Statistical Data Interpretation;Statistical Methods;Sterilization;Stimulant;Sum;tandem mass spectrometry;Techniques;Time;Tissues;tool;uptake;Uterus;Work

PROJECT_TITLE: Mass Spectrometry Quantitation


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Neurosciences

PI_NAMEs: YAKEL, JERREL L (contact)

PROJECT_TERMS: Anxiety;Behavior;Behavioral;Behavioral Assay;behavioral outcome;behavioral phenotyping;behavioral study;Biological Assay;Cell Physiology;circadian;Communities;Contracts;Data Analyses;Electrophysiology (science);Equipment;Experimental Designs;Functional disorder;Genetic;Goals;Home;Implant;in vivo;insight;Laboratories;Learning;Manuscripts;Memory;Mental Depression;Mental disorders;Methods;Microscope;Mission;Molecular;Monitor;Motor;Mus;National Institute of Environmental Health Sciences;Nervous System Disorder;Nervous System Physiology;neural;neurobehavioral;Neurons;Neurosciences Research;neurotechnology;novel;optical imaging;Optics;optogenetics;Phenotype;Photometry;Preparation;Reflex action;Research;Research Personnel;Sensory;Social Behavior;Standardization;synaptic function;Techniques;Training;United States National Institutes of Health

PROJECT_TITLE: Neurobehavioral Core Laboratory


NIH_SPENDING_CATS: Chronic Fatigue Syndrome (ME/CFS);Clinical Research;Genetics;Natural Products

PROJECT_TERMS: Acids;Affinity;Binding;Binding Proteins;Botanicals;Brain;Chemistry;Chronic Fatigue Syndrome;Consult;Core Facility;experimental study;G-Quartets;Glutathione;Goals;Histones;Human;Laboratories;leukemia;Measures;metabolomics;Mus;National Institute of Environmental Health Sciences;Nucleotides;Patients;peptide structure;Peptides;Pharmaceutical Preparations;Poly-fluoroalkyl substances;Proteins;Research;Research Personnel;Research Project Grants;Resources;RNA;Robin bird;saliva sample;Sampling;stable isotope;stool sample;Structure;Survivors;Testing;Yeasts

PROJECT_TITLE: NMR Research Core Facility


NIH_SPENDING_CATS: Bioengineering

PI_NAMEs: JARMUSCH, ALAN  (contact)

PROJECT_TERMS: Biocompatible Materials;Biological;Biological Assay;chemical property;chemical standard;Chemicals;Chromatography;Complement;Complex;complex data;Consultations;Core Facility;Coupled;Data;data acquisition;Data Analyses;data analysis pipeline;Databases;Dedications;Drosophila genus;Environmental Exposure;Evaluation;Experimental Designs;experimental study;Health;High Pressure Liquid Chromatography;Human;hydrophilicity;improved;Intramural Research Program;ion mobility;Kidney;Laboratories;liquid chromatography mass spectrometry;Liver;mass spectrometer;Mass Spectrum Analysis;Measurement;Measures;metabolomics;Methods;Mus;National Institute of Environmental Health Sciences;novel;Phase;physical property;Plasma;Preparation;Procedures;Protocols documentation;quality assurance;Quality Control;Research;Research Personnel;Resolution;Resources;response;reversed phase chromatography;Sampling;Services;Shapes;Signal Transduction;Spectrometry;System;Time;Training;United States National Institutes of Health;Urine

PROJECT_TITLE: Mass Spectrometry-based Untargeted Metabolomics


PI_NAMEs: HOOTH, MICHELLE  (contact)

PROJECT_TERMS: Academia;Address;Advisory Committees;Agreement;Area;Budgets;Chemistry;Collaborations;college;Communication;Computer software;Concept Review;Contracts;Data;Decision Making;design;Development;doctoral student;Ensure;Environment;Environmental Hazards;Environmental Health;equity, diversity, and inclusion;Fellowship Program;Goals;Health;health science research;Human Resources;improved;Industry;Infrastructure;innovation;interest;Knowledge;Lead;Leadership;Maintenance;Methods;Mission;Monograph;multidisciplinary;National Institute of Environmental Health Sciences;National Toxicology Program;next generation;operation;outreach;Peer Review;Policies;pre-doctoral;Process;Professional counselor;Program Development;programs;Public Health;PubMed;Reporting;Research;research and development;Research Contracts;Research Project Grants;Resources;science education;Science Policy;Scientist;Series;Services;Structure;tool;Toxicology;Training;translational scientist;Travel;Trust;Vision;web site;Work;Workforce Development

PROJECT_TITLE: Research Services Supporting the Division of Translational Toxicology


ACTIVITY: ZIG

NIH_SPENDING_CATS: Genetics;Human Genome

PI_NAMEs: MACLARTY, ARTHUR  (contact)

PROJECT_TERMS: Accreditation;Administrative Personnel;Amendment;Analgesics;Anesthesia and Analgesia;Anesthetics;animal care;Animal Care and Use Committees;Animal Experimentation;Animal Model;Animal Welfare;Animals;Area;Behavioral Research;Biomedical Research;Blood;Caring;Collection;comparative;Consultations;Contracts;Derivation procedure;design;Disaster Planning;Educational process of instructing;Educational Status;Electronics;Employee;Ensure;environmental enrichment for laboratory animals;Euthanasia;Financial Support;follow-up;Genotype;Government;Guidelines;Hypersensitivity;Individual;Injections;Injury;International;investigator training;Laboratory Animal Medicine;Laboratory Animals;Laboratory mice;Logistics;Medicine;meetings;Methods;Mission;model development;Monitor;Mus;National Human Genome Research Institute;occupational health/safety;Operative Surgical Procedures;personal protective equipment;Preparation;Prevention;Principal Investigator;Procedures;Program Evaluation;programs;protocol development;Protocols documentation;Recommendation;Records;Regulation;Reporting;Research;Research Infrastructure;Research Personnel;Research Support;response;restraint;Rodent;Safety;Schedule;Security;skills;Surgeon;Suture Techniques;Techniques;Testing;Training;Training Programs;Training Technics;Transgenic Organisms;treatment research;United States National Institutes of Health;Update;virtual;Work

PROJECT_TITLE: NHGRI/DIR Animal Research Infrastructure


ACTIVITY: ZIJ

PI_NAMEs: HULL, SARA  (contact)

PROJECT_TERMS: Address;Admission activity;Area;Artificial Intelligence;Awareness;career;Career Choice;career development;Career Mobility;career networking;Child;Clinical;cohort;Collaborations;Communication;community engagement;community involvement;Competence;Contractor;Development;diversity and equity;doctoral student;Documentation;Education;Education and Outreach;education resources;Educational Curriculum;Educational Status;Educational workshop;Ensure;equity, diversity, and inclusion;Ethnic equity;Event;experience;Extramural Activities;Fellowship Program;Focus Groups;Fostering;Funding Opportunities;Future;genetic approach;genetic counselor;Genetic Research;genome sciences;Genomic approach;Genomic medicine;Genomics;Goals;Grant;harassment;Health;health equity;Individual;innovation;Intramural Research Program;K-Series Research Career Programs;Lead;Leadership;Learning;member;Mental Health;Mentors;Mission;National Human Genome Research Institute;operation;outreach program;Participant;Pathway interactions;Persons;Postbaccalaureate;Postdoctoral Fellow;pre-doctoral;Procedures;professional atmosphere;programs;Public Speaking;Racial Equity;recruit;Research;Residencies;Resources;Role;Science;Scientist;Series;skills;Students;summer internship;summer program;synergism;Teacher Professional Development;Training;training opportunity;Training Programs;United States National Institutes of Health;Update;Visit;Work;working group;Writing

PROJECT_TITLE: NHGRI/DIR Education and Outreach Programs


ACTIVITY: ZIK

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Orphan Drug;Prevention;Rare Diseases

PI_NAMEs: SOLOWIEJ, ANNA  (contact)

PROJECT_TERMS: Agreement;Alkaptonuria;All of Us Research Program;Amendment;analog;Attention deficit hyperactivity disorder;Australia;Biocompatible Materials;Biological Assay;Biological Markers;Biological Sciences;Cell Line;Classification;clinical development;Clinical Trials;Cobalamin;cognitive skill;Collaborations;commercialization;Consult;Cooperative Research and Development Agreement;Copyright;Corynebacterium;Counseling;cybersickness;Data;data exchange;Databases;Development;Disclosure;Disease;Educational Materials;Employee;Ensure;Europe;experience;Flow Cytometry;Funding;Future;Gaucher Disease;gene therapy;Gifts;Grant;Hallux structure;Health;Histologic;Human;Image;induced pluripotent stem cell;Institution;instrument;Intellectual Property;interest;International;Internships;invention;Japan;ketotic hyperglycinemia;Laboratory Research;Lamin Type A;Laws;Lead;Legal;Legal patent;Licensing;Marketing;material transfer agreement;Mediation;Methods;methylmalonic aciduria;Mission;mouse model;National Human Genome Research Institute;Natural History;Nonprofit Organizations;Oligonucleotides;Patients;Pharmacologic Substance;Policies;Postdoctoral Fellow;prevent;Private Sector;programs;Public Health;Reporting;Research;Research Personnel;Research Support;Resources;Russia;Science Policy;Scientist;Sialic Acids;Singapore;Speed;summer student;symposium;System;Technology;Technology Transfer;tool;Training;Transact;Transfer Agreement;Treaty;United States;United States National Institutes of Health;Universities;virtual assessment;virtual reality;virtual reality intervention;Visit;Work;Writing

PROJECT_TITLE: NHGRI/DIR Technology Transfer Program


ADMINISTERING_IC: AI

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: BOZEMAN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: MONTANA STATE UNIVERSITY - BOZEMAN

ORG_STATE: MT

PHR: PROJECT NARRATIVE Lyme disease is the most common vector-borne infection in the United States, with nearly 500,000 cases per year. The bacterium Borrelia (Borreliella) burgdorferi causes Lyme disease when it is transmitted to humans by a tick vector. Bacteria, including B. burgdorferi, can themselves be infected by bacteriophages (phages), a type of virus. This application proposes to fill a knowledge gap regarding the fundamental understanding of B. burgdorferi phage biology, including the molecular basis of phage replication and the mechanisms by which phage facilitate movement of genes between bacteria, enhancing the persistence of B. burgdorferi in nature via reinfection of its hosts.

PI_NAMEs: SECOR, PATRICK R (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TITLE: Phage-mediated horizontal gene transfer in Borrelia burgdorferi