ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative Tight junctions (TJs) are protein assemblies involved in cell adhesion and intercellular transport of molecules through endothelial and epithelial tissues. While many proteins amass at TJs, two families of membrane proteins predominate TJ assembly, organization, and function. The goals of this research are to establish a fundamental understanding of how these two membrane protein families structurally assemble TJs, to identify how their disassembly contributes to TJ dysfunction, and to apply this knowledge by creating new strategies for tissue-specific treatment of TJ-linked diseases in humans.

PI_NAMEs: VECCHIO, ALEX J. (contact)

PROJECT_TERMS: Alzheimer's Disease;Architecture;Bacterial Toxins;base;Biochemical;Bioinformatics;Biophysics;Blood - brain barrier anatomy;Cell Adhesion;Cell membrane;Cells;Charge;Complex;Cytoskeleton;design;Development;Disabling;Disease;Ear Diseases;Endothelial Cells;Endothelium;Environment;Epidermis;Epithelial Cells;Epithelium;experimental study;Extracellular Space;Eye diseases;Family;Food Poisoning;Functional disorder;Gland;Goals;Hepatitis;Human;Huntington Disease;Individual;Inflammatory Bowel Diseases;insight;Integral Membrane Protein;interdisciplinary approach;Ions;Kidney;Knowledge;Laboratories;Limb structure;Link;macromolecular assembly;Malignant Neoplasms;Membrane;membrane assembly;Membrane Proteins;Modification;Molecular;Molecular Conformation;Molecular Structure;novel therapeutics;Organ;Organism;Parkinson Disease;Pathology;Permeability;programs;Protein Family;Proteins;reconstruction;Research;scaffold;Shapes;Side;skin disorder;small molecule;Stroke;structural biology;Structure;Tight Junctions;Tissues;Transport Process;Vertebrates;wasting

PROJECT_TITLE: Structure and assembly of membrane proteins at tight junctions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: DENVER

ORG_COUNTRY: UNITED STATES

ORG_DEPT: CHEMISTRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF DENVER (COLORADO SEMINARY)

ORG_STATE: CO

PHR: PROJECT NARRATIVE Protein misfolding and aggregation are the root cause of many debilitating diseases, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). We are only beginning to appreciate that DNA and RNA play important roles in protein folding and aggregation. This research investigates the underlying principles of how nucleic acids prevent protein misfolding and aggregation, and promote protein oligomerization; eventually, these discoveries could lead to nucleic acid-based therapies for protein misfolding diseases.

PI_NAMEs: HOROWITZ, SCOTT ANDREW (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: activation-induced cytidine deaminase;Address;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;bacterial genetics;Base Sequence;Biochemistry;Biology;Biophysics;Cells;combat;Data;Disease;DNA;Environment;Escherichia coli;Foundations;Future;improved;insight;interdisciplinary approach;Investigation;Lead;Molecular;Molecular Biology;Molecular Chaperones;Neurodegenerative Disorders;Nucleic Acids;Parkinson Disease;Play;prevent;protein aggregation;protein folding;protein misfolding;protein oligomer;proteostasis;Research;RNA;Role;Structure;Work

PROJECT_TITLE: Nucleic Acids Roles in Protein Folding and Aggregation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


NIH_SPENDING_CATS: Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: NEW YORK

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: HUNTER COLLEGE

ORG_STATE: NY

PHR: Relevance Statement The unmet need in the treatment of cancers and Opioid Use Disorders (OUD) poses a great threat to human health and welfare. The conventional drug discovery process has yielded very few successes. New approaches are needed to reduce the time and cost in drug discovery and development. We propose a novel machine learning powered systems pharmacology approach to accelerate drug discovery and development.

PI_NAMEs: XIE, LEI  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Acceleration;Address;Adopted;Advocate;Affinity;Agonist;antagonist;anti-cancer;Area;Big Data;Binding;biological systems;Biomedical Research;cancer therapy;Chemicals;Clinical;Collaborations;Communities;Complex;computer framework;computer infrastructure;Computer Models;computerized tools;Computing Methodologies;cost;Data;Data Set;deep learning;deep learning algorithm;design;Disease;Docking;Dopamine Antagonists;drug action;drug candidate;Drug Design;drug development;drug discovery;drug efficacy;Drug Modelings;drug repurposing;Drug Targeting;druggable target;Effectiveness;experience;Failure;functional genomics;Genes;Genome;genome sequencing;genome wide association study;genome-wide;Genomics;Glioblastoma;Health;Human;Human Genome;improved;In Vitro;in vivo;inhibitor;innovation;Interdisciplinary Study;Knowledge;Laboratories;laboratory experiment;Lead;Ligands;Link;Machine Learning;Malignant Neoplasms;Marketing;Methodology;Methods;Modernization;molecular dynamics;new therapeutic target;novel;novel strategies;novel therapeutics;opioid use disorder;Orphan;Outcome;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacology;Phase III Clinical Trials;precision medicine;Process;programs;Proteins;Proteome;Proteomics;Research;Resort;screening;side effect;structural genomics;Structure;success;System;Techniques;Testing;Time;training data;translational applications;United States National Institutes of Health;Vision;welfare;whole genome

PROJECT_TITLE: AI-powered chemical proteomics for drug discovery targeting orphan proteins

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: HS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: CLEVELAND

ORG_NAME: UNIVERSITY HOSPITALS OF CLEVELAND

ORG_STATE: OH

PHR: The Center to Improve Diagnosis will focus upon developing diagnostic standards and recommendations for common diagnostic problems. Our strategy will be both data and consensus driven. Recommendations for best diagnostic practices will be formulated by a panel of diagnosticians in collaboration with the research team.

PI_NAMEs: DOLANSKY, MARY ;KOOPMAN GONZALEZ, SARAH J;MILLER, MARLENE ROSEMARY;PRONOVOST, PETER J.;RAO, GOUTHAM  (contact)

PROGRAM_OFFICER_NAME: COSBY, KAREN

PROJECT_TITLE: Center to Improve Clinical Diagnosis


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: ATLANTA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The blood-brain barrier (BBB) formed by the cerebrovascular endothelial cells is necessary for normal brain function. Endothelial barrier opening and the consequent BBB disruption occurs in many brain diseases, leading to leakage of blood components into the brain, edema formation, and potentially death. Genetic deletion of the newly identified protein Poldip2 protects against endothelial barrier opening and brain edema formation, and this proposal investigates the underlying cellular and molecular mechanisms with a goal towards developing new therapies.

PI_NAMEs: HERNANDES, MARINA SORRENTINO (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Actins;Adaptor Signaling Protein;Address;adenovirus mediated delivery;Affect;Anatomy;Animal Model;Area;Astrocytes;Blood;Blood - brain barrier anatomy;Blood brain barrier dysfunction;blood-brain barrier disruption;blood-brain barrier function;blood-brain barrier permeabilization;Brain;Brain Diseases;Brain Edema;brain endothelial cell;Brain Ischemia;Cell Physiology;cell type;Cell-Cell Adhesion;Cells;Central Nervous System;Central Nervous System Diseases;central nervous system vasculature;Cerebral endothelium;Cerebral hemisphere hemorrhage;Cerebral Ischemia;cerebrovascular;Cerebrovascular system;Cessation of life;Clinical;cytokine;Cytoskeletal Modeling;Cytoskeleton;Data;Dependovirus;Development;disability;Down-Regulation;Edema;Endothelial Cells;Endothelium;Event;Extravasation;Gene Expression Profile;Genetic;Genetic Transcription;Goals;Hemorrhage;Heterozygote;Homeostasis;improved;In Vitro;in vivo;in vivo evaluation;Inflammation;insight;Knock-out;Knockout Mice;Leukocytes;Link;Maintenance;Malignant Neoplasms;Measures;Mediating;Molecular;Molecular Weight;mortality;Motor;motor function improvement;Multiple Sclerosis;Mus;Myosin Light Chains;NADPH Oxidase;neuroinflammation;neuropathology;neurotransmission;novel;novel therapeutics;Outcome;Pathology;Pathway interactions;Pericytes;Permeability;Phenotype;Phosphorylation;Physiological;Plasma Proteins;Play;Polymerase;prevent;Process;Property;Proteins;Publishing;Reactive Oxygen Species;Regulation;response;rho;Role;Sampling;Series;short hairpin RNA delivery;Signal Pathway;single-cell RNA sequencing;Stress Fibers;Stroke;Structure;Tertiary Protein Structure;Testing;Therapeutic;therapeutic target;Tight Junctions;Tissues;Tracer;Traumatic Brain Injury;Tyrosine Phosphorylation;Vascular Permeabilities;Water Movements

PROJECT_TITLE: Poldip2 and the Brain Endothelial Barrier Function: Understanding Mechanisms that Regulate the Blood Brain Barrier Integrity

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Precision Medicine;Rare Diseases

ORG_CITY: SEATTLE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative (3 Sentences) As Director of the Core Laboratory for Advanced Cancer Image Analysis at the University of Washington, my approach for both multi-center and cooperative group research analysis begins with consultation during regular meetings encouraging the programs to collect as much information as practical for the study, periodically provide acquisition, reconstruction and imaging protocols, laboratory analysis for tracer metabolites, manage patient imaging studies, analyze the collected imaging and patient meta-data, provide advanced image processing procedures, generate model simulations, present the analysis results at conferences and through peer-reviewed publications. To ensure fulfillment of the specific aims I would actively pursue detailed analysis of the data including development of data structures for managing the information, providing both common and innovative data analysis methodology, performing simulations if necessary and co-author publications with particular emphasis on writing the technical methods of analysis of advanced imaging studies for a variety of cancers that benefits the scientific community.

PI_NAMEs: MUZI, MARK  (contact)

PROGRAM_OFFICER_NAME: ZHANG, HUIMING

PROJECT_TERMS: Advanced Malignant Neoplasm;American College of Radiology Imaging Network;animal imaging;Avidity;Biochemical Pathway;Biochemistry;Brain Neoplasms;cancer imaging;career;Clinical Trials;Collaborations;Communities;Consultations;cost;Data;Data Analyses;Data Reporting;design;Development;Eastern Cooperative Oncology Group;Ensure;European Organization for Research and Treatment of Cancer;Foundations;Funding;Goals;Grant;Head and neck structure;Human;human imaging;Image;Image Analysis;image processing;imaging program;imaging study;improved;Information Management;innovation;International;kinetic model;Laboratories;Magnetic Resonance Imaging;Malignant Neoplasms;Manuscripts;Medical Imaging;meetings;member;Metadata;Methodology;Methods;models and simulation;novel;Oncology;Patient imaging;Patients;Peer Review;Pennsylvania;PET/CT scan;Positron-Emission Tomography;Procedures;programs;Protocols documentation;Provider;Publications;Publishing;quantitative imaging;Radiation Dose Unit;radiomics;reconstruction;Research;Research Personnel;simulation;Structure;symposium;technical writing;Tilia;Tracer;Universities;Washington;Work;working group


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Psoriasis;Racial and Ethnic Minority Health Research

ORG_CITY: ANN ARBOR

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The proposed research focuses on identifying the regulatory mechanisms of psoriasis-associated signals by utilizing an innovative strategy that leverages trans-ethnic and multi-genomic analysis. Successful completion of this project will significantly advance understanding of the genetic basis for inflammatory signaling in keratinocytes, as well as its impact on skin inflammation heterogeneity and clinical outcomes among psoriatic patients. Our proposal is highly relevant to the part of the NIH's mission that pertains to improving the understanding and management of human diseases.

PI_NAMEs: TSOI, LAM CHEUNG (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Affect;African American;African American population;African ancestry;Alleles;American;ATAC-seq;Biological;Biological Assay;Biological Markers;Bromouridine sequencing;causal variant;Cells;Chromatin;Chromosome Mapping;Chronic;Clinical;cohort;comorbidity;Complex;cost;CRISPR/Cas technology;cytokine;Data;design;Development;Direct Costs;Disease;disease disparity;disease heterogeneity;disease model;Epigenetic Process;Ethnic Origin;Etiology;European;Facilities and Administrative Costs;Functional disorder;functional genomics;Gene Frequency;Genetic;genetic architecture;Genetic Models;Genetic study;Genetic Transcription;genetic variant;Genetic Variation;genome wide association study;genomic data;Genomics;Genotype;Goals;Haplotypes;Heterogeneity;Heterozygote;Hi-C;high risk;high throughput technology;human disease;IL17 gene;Immune;Immune signaling;Immune System Diseases;improved;Individual;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;innovation;inter-individual variation;interleukin-23;keratinocyte;Machine Learning;Maps;Mediating;Mediator;Mission;Modeling;Molecular;multi-ethnic;multimodality;Multiomic Data;multiple omics;Nucleic Acid Regulatory Sequences;Outcome;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Play;Population;Population Heterogeneity;precision medicine;predict clinical outcome;Predisposition;Prevalence;promoter;Psoriasis;Public Health;Quantitative Trait Loci;Regulation;Research;Resolution;Resources;response;Role;Shapes;Signal Transduction;Skin;skin disorder;Susceptibility Gene;TNF gene;transcriptome;transcriptomics;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Integrative and trans-ethnic study to understand psoriasis associated signals


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: GRONINGEN

ORG_COUNTRY: NETHERLANDS

ORG_FIPS: NL

ORG_NAME: GRONINGEN UNIVERSITY

PHR: Maglia PROJECT NARRATIVE Among the techniques that have been proposed to sequence proteins at the single-molecule level, nanopores promise the high throughput sequencing of unlabelled and full-length proteins. The main challenges lie in controlling the unfolding and transport of proteins across nanopores, stretching the polypeptides and recognizing individual amino acids. Using his unique skills, the applicant will design nanopore-machines that will tackle the fundamental challenges in single-molecule nanopore sequencing. 1

PI_NAMEs: MAGLIA, GIOVANNI  (contact)

PROGRAM_OFFICER_NAME: FUFA, TEMESGEN D

PROJECT_TERMS: Address;Amino Acid Sequence;Amino Acids;amino group;Biological Markers;Biomedical Engineering;Carrier Proteins;Complex;cost;design;Devices;Diameter;Disease;DNA sequencing;Engineering;Enzymes;Generations;Geometry;High-Throughput Nucleotide Sequencing;Hydrophobicity;Individual;Length;Link;Molecular Machines;multicatalytic endopeptidase complex;nanoengineering;nanopore;nanoscale;Osmosis;Peptide Fragments;Peptide Hydrolases;Peptide Sequence Determination;Peptides;physical property;polypeptide;Pore Proteins;portability;Positioning Attribute;Posttranslational Amino Acid Modification;Preparation;Proteins;Proteomics;Reaction;real time monitoring;Research;Sampling;sensor;Shapes;Shotguns;single molecule;skills;Speed;Stretching;Techniques;Technology;Time;unfoldase

PROJECT_TITLE: Designed nanopores for single-molecule protein sequencing


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: CHICAGO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative: Small nucleolar RNA (snoRNA) are natural guide RNAs that direct cellular RNA-RNA interactions with many numerous functional consequences. This application proposes to investigate the mammalian snoRNA-RNA interactome by leveraging newly developed sequencing technologies and inventing new approaches. We expect uncovering functional roles of snoRNA-RNA interactions in gene expression regulation and human diseases.

PI_NAMEs: HE, CHUAN ;PAN, TAO  (contact)

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TERMS: Address;Antisense Oligonucleotides;Binding;Binding Sites;Biological Process;biological systems;Biology;bisulfite;Cell Line;cell type;Cells;Complex;Gene Expression;Gene Expression Regulation;Genes;Guide RNA;Human;human disease;Human Genome;Individual;invention;Investigation;kethoxal;knock-down;Knowledge;Maps;Messenger RNA;Methods;Modification;mRNA Precursor;mRNA Stability;mRNA Translation;Mus;Mutation;nanopore;novel sequencing technology;novel strategies;Nucleotides;Orphan;Pathway interactions;protein complex;Proteins;Pseudouridine;Regulation;Research;Resolution;response;Ribonucleoproteins;Ribosomal RNA;Ribosomes;RNA;RNA Binding;RNA Splicing;RNA-Binding Proteins;Role;Small Nucleolar Ribonucleoproteins;Small Nucleolar RNA;Spliceosomes;Stress;Technology;Time;Tissues;tool;transcriptome;transcriptomics;Translations;Untranslated RNA

PROJECT_TITLE: Targets and functions of the mammalian snoRNAome

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative: Cancer is a substantial public health burden. Despite recent progress through the use of precision cancer medicines that have improved outcomes for cancer patients, the development of acquired resistance to these medicines has impeded transforming most cancers into chronic or curable conditions. This NCI ARTNet Research Program aims to understand the basis of acquired drug resistance to improve cancer treatments and patient survival.

PI_NAMEs: BIVONA, TREVER G (contact);ROTH, JACK

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: acquired drug resistance;Address;Area;cancer cell;Cancer Etiology;Cancer Patient;cancer therapy;cancer type;CD47 gene;Cell Survival;Cells;Chronic;Clinical;clinical translation;Communities;Cues;cytokine;Data Science Core;Data Set;data sharing;Development;Disease;Drug resistance;Ecosystem;Ensure;Epidermal Growth Factor Receptor;Event;Extracellular Matrix;Fibroblasts;Foundations;Funding;Future;Geography;Goals;Human;humanized mouse;Immune;immunosuppressive checkpoint;improved;improved outcome;innovation;KRAS2 gene;Link;Lung;Lung Adenocarcinoma;Macrophage;Macrophage Activation;Malignant neoplasm of lung;Malignant Neoplasms;Medicine;Methods;Modeling;Molecular;molecular targeted therapies;mortality;mouse model;mutant;Nature;neoplastic cell;NF-kappa B;Non-Small-Cell Lung Carcinoma;Oncogenic;Organoids;Paracrine Communication;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;PD-1/PD-L1;PDPK1 gene;Pharmaceutical Preparations;Pre-Clinical Model;precision oncology;prevent;Process;programs;Progress Reports;Proteomics;Public Health;Refractory;Research;Research Project Grants;Resistance;resistance mechanism;response;Signal Transduction;Specimen;success;System;targeted treatment;Testing;Therapeutic;therapeutic evaluation;therapy resistant;treatment strategy;tumor;tumor microenvironment;tumor progression;tumor xenograft

PROJECT_TITLE: BAY AREA & ANDERSON TEAM AGAINST ACQUIRED RESISTANCE - U54 PROGRAM (BAATAAR-UP)


NIH_SPENDING_CATS: Cancer;Data Science;Lung;Lung Cancer

PI_NAMEs: BLAKELY, COLLIN M (contact)

PROJECT_TERMS: Advocate;American Association of Cancer Research;American Society of Clinical Oncology;Animal Experimentation;Area;Basic Science;Biology;Budgets;Cancer Advocacy;Chemicals;Clinical;Clinical Research;Collaborations;Communication;Communities;Data;Data Coordinating Center;Data Science Core;data sharing;Disputes;Doctor of Philosophy;Ensure;Epidermal Growth Factor Receptor;Evaluation;Event;Evolution;Feedback;Funding;Generations;Goals;human subject;IACUC;Institution;Institutional Review Boards;Interpersonal Relations;Knowledge;KRAS2 gene;Lead;Leadership;Malignant neoplasm of lung;Malignant Neoplasms;meetings;Modeling;Molecular;molecular targeted therapies;Organoids;Patient advocacy;patient advocacy group;Patients;programs;Progress Reports;Reporting;Research;Research Personnel;Resistance;Resource Sharing;Role;Signal Transduction;single cell analysis;symposium;targeted treatment;Teleconferences;Therapeutic;therapy resistant;timeline;Translational Research;Travel;tumor;tumor microenvironment;Update;Work;Xenograft procedure

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Each cell interacts with its environment, and 1000s of human genes encode the needed hormones, receptors, transporters, and enzymes. Most are produced in the secretory pathway, but the complexity of this pathway makes it difficult to diagnose the molecular basis of associated diseases, including Alzheimer’s disease, metabolic syndrome, cancer, and many infectious diseases. Here we develop a computational platform and experimental data resource enabling researchers to study the pathway as a whole system.

PI_NAMEs: LEWIS, NATHAN ENOCH (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: algorithm development;Algorithms;Alzheimer's Disease;amyloid formation;base;Cell Adhesion Molecules;Cell Communication;cell type;Cells;Code;Communicable Diseases;Communication;Communities;computational platform;Computer Models;data resource;Disease;endoplasmic reticulum stress;Environment;Enzymes;experimental study;extracellular;Extracellular Matrix;Genes;Genomics;Hormone secretion;Hormones;Human;Human Genome;Individual;Liver;Malignant Neoplasms;Maps;Mathematics;Membrane Proteins;Messenger RNA;Metabolic syndrome;Modeling;Molecular Diagnosis;Pathway interactions;Process;Production;Protein Secretion;Proteins;receptor;Research Personnel;Resources;Role;Signal Transduction;software development;System;Systems Biology;Techniques;Tissues;tool;trafficking;Work

PROJECT_TITLE: Unraveling the mammalian secretory pathway through systems biology and algorithm development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Nutrition;Obesity;Pediatric;Physical Activity;Prevention

ORG_CITY: COLUMBIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Little is known about monthly patterns in BMI change and associated obesogenic behaviors, the dynamic relationship of these behaviors with one another, the social, environmental, and biological determinates of these behaviors, and their link with changes in BMI in children. The proposed study will use the principles of developmental psychopathology to understand BMI development and associated behavioral, social, environmental, and biological determinates. This approach has the potential to uncover developmentally sensitive periods when children are susceptible to becoming obese and can provide insight into mechanisms for change.

PI_NAMEs: WEAVER, ROBERT G (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: 10 year old;Acceleration;Affect;Age;Behavior;Behavioral;Biological;Biological Factors;body map;Body mass index;Body measure procedure;Body Patterning;Calendar;Case Study;Child;circadian;cohort;critical period;Darkness;Data;Deceleration;design;Development;Dietary intake;Environmental Risk Factor;Excision;falls;fifth grade;Functional disorder;Genetic;Guidelines;Height;innovation;insight;Intervention;kindergarten;Knowledge;lens;Light;Link;Measurement;Measures;Methods;Modeling;novel;Nursery Schools;Obesity;obesity in children;obesogenic;Outcome;Pattern;Physical activity;Predisposition;Process;Protocols documentation;Psychopathology;Public Health;recruit;Research;Risk;Sampling;Schools;Seasons;second grade;sedentary;sex;Sleep;social;social factors;social relationships;Standardization;Structure;theories;Time;tv watching;Variant;Weight;Weight Gain;Work

PROJECT_TITLE: Identifying Patterns of BMI Development and Associated Behavioral, Social, Environmental, Genetic, and Biological Factors for Children from 3-10 Years

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: WANG, JING  (contact)

PROJECT_TERMS: Algorithms;Applications Grants;Area;Basic Science;Bayesian Network;Bioconductor;Bioinformatics;Biological Models;Biology;Biomedical Engineering;Biometry;Biopsy;Cell Communication;Cell Line;Cells;central database;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;complex data;Computational algorithm;Computational Biology;computerized data processing;Computing Methodologies;Consult;Data;Data Analyses;data analysis pipeline;data integration;data resource;Data Science Core;data sharing;Databases;design;Documentation;Ecosystem;Ensure;Epidermal Growth Factor Receptor;Faculty;Genomics;Goals;KRAS2 gene;Laboratories;Linear Models;Malignant Neoplasms;Manuscripts;Methods;Mission;Modeling;molecular targeted therapies;Multiomic Data;multiple datasets;multiple omics;mutant;Network-based;Non-Small-Cell Lung Carcinoma;Parameter Estimation;Pathway Analysis;Play;programs;Proteomics;Reporting;Reproducibility;Research;Research Personnel;Resistance;Role;Science;Scientist;Specimen;Statistical Algorithm;Structure;success;System;Testing;Therapeutic;tool;transcriptomics;Translational Research;tumor;tumor microenvironment;Universities;Work

PROJECT_TITLE: Data Science Core


PI_NAMEs: BIVONA, TREVER G (contact)

PROJECT_TERMS: Antitumor Response;Area;Automobile Driving;biomarker driven;biomarker identification;cancer cell;Cancer Etiology;cancer subtypes;CD44 gene;CD47 gene;Cell Communication;Cell Survival;cell type;Cells;Chronic;Clinical;clinical translation;Clinical Treatment;combat;Communication;Coupled;CSF1 gene;cytokine;Drug Tolerance;Ecosystem;Epidermal Growth Factor Receptor;Evolution;Extracellular Matrix;Fibroblasts;Funding;Future;Genetic;Goals;Heterogeneity;Immune;immunosuppressive checkpoint;improved;improved outcome;inhibitor;innovation;insight;Integrins;Knowledge;KRAS2 gene;Ligands;Macrophage;Malignant Neoplasms;Mediating;Migration Inhibitory Factor;Modeling;Molecular;molecular targeted therapies;mortality;mutant;neoplastic cell;Non-Small-Cell Lung Carcinoma;Oncogenes;Oncogenic;paracrine;Paracrine Communication;Pathway interactions;Patient-Focused Outcomes;Patients;PDGFRB gene;pharmacologic;Phenotype;Platelet-Derived Growth Factor;programmed cell death protein 1;programs;Proteomics;PTK2 gene;Research Project Grants;Residual Neoplasm;Resistance;resistance mechanism;response;Role;Signal Transduction;spatial relationship;Specimen;targeted agent;Therapeutic;therapeutic target;translational approach;translational goal;treatment response;tumor;tumor microenvironment;tumor progression;Work

PROJECT_TITLE: Clinical specimen tumor-TME acquired resistance


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer;Rare Diseases;Urologic Diseases;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Through mentored research training and career development of the next generation of interdisciplinary team members, leaders, and innovators in health services and patient-centered outcomes, clinical epidemiology, and dissemination and implementation, the UCLA Patient-Centered Outcomes Research Training in Urologic and Gynecologic Cancers (PCORT UroGynCan) program will increase the pace and volume of scientific discovery and innovation in the diagnosis, treatment, and prevention of urologic and gynecologic cancers and advance our knowledge of delivery and implementation strategies for proven interventions in real-world practice and community settings. In closing the gap between evidence-based interventions and their uptake across diverse health services settings and populations, including historically underserved populations who manifest wide disparities in health status, PCORT UroGynCan will contribute to improved health system performance as well as outcomes and health-related quality of life of patients and their families.

PI_NAMEs: KRAKOW, DEBORAH ;LITWIN, MARK S. (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Malignant Female Reproductive System Neoplasm;Patient-Focused Outcomes;Research Training;Urologic Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


PI_NAMEs: ROTH, JACK  (contact)

PROJECT_TERMS: acquired drug resistance;Area;Cells;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Colony-Stimulating Factor Receptors;Combination immunotherapy;CRISPR screen;Data;drug efficacy;Drug resistance;Drug Screening;Drug Targeting;drug testing;Epidermal Growth Factor Receptor;Future;Gene Expression;Histology;Human;humanized mouse;Immune;immune checkpoint blockade;Immune response;inhibitor;innovative technologies;KRAS2 gene;Macrophage;Malignant Neoplasms;Modeling;Molecular;molecular subtypes;mutant;Mutation;NF-kappa B;Non-Small-Cell Lung Carcinoma;novel;novel therapeutics;Organoids;overexpression;Pathway interactions;Patients;PDPK1 gene;phosphoinositide-dependent kinase 1;pre-clinical;programs;protein expression;Proteins;Proteomics;Residual Neoplasm;Resistance;resistance mechanism;response;restoration;Role;single-cell RNA sequencing;Small Interfering RNA;Stromal Cells;Testing;Therapeutic;therapeutic target;transcriptome sequencing;treatment response;treatment strategy;tumor;tumor microenvironment;Tumor-associated macrophages;tumor-immune system interactions;Tyrosine Kinase Inhibitor

PROJECT_TITLE: PDX tumor-TME acquired resistance


NIH_SPENDING_CATS: Biotechnology;Cancer;Lung;Lung Cancer

PI_NAMEs: BANDYOPADHYAY, SOURAV  (contact)

PROJECT_TERMS: acquired drug resistance;Acute;Address;advanced disease;Air;Alveolar;anti-cancer treatment;Antibodies;Antibody-drug conjugates;Area;Bioinformatics;Biology;Biopsy;Blood Vessels;Cancer Patient;carcinogenesis;CD44 gene;CD47 gene;CD47-SIRPα;Cell Communication;cell type;Cells;Clinical;Clinical Treatment;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR screen;Development;Drug Interactions;Drug resistance;drug sensitivity;Endothelium;Engineering;Epidermal Growth Factor Receptor;Epithelium;Exhibits;Extracellular Matrix;Fibroblasts;Gefitinib;Genetic;Glucuronic Acids;Glycosaminoglycans;Goals;Grant;Histology;Human;Immune;immune reconstitution;improved;In Vitro;in vivo;Infiltration;inhibitor;KRAS2 gene;lead candidate;Lethal Genes;Liquid substance;Lung;Macrophage;Mass Spectrum Analysis;Modality;Modeling;Molecular;molecular targeted therapies;Mus;mutant;Mutation;Myelogenous;Nature;neoplastic;Non-Small-Cell Lung Carcinoma;novel;Organoids;Pathway interactions;patient derived xenograft model;Patients;PD-1/PD-L1;PDL1 pathway;Penetrance;Phagocytes;Phagocytosis;Pharmacology Study;phosphoproteomics;preservation;Primary Neoplasm;Production;programs;Progressive Disease;prospective;Proteins;Proteoglycan;Proteome;Proteomics;PTPNS1 gene;reconstitution;Refractory Disease;Regulation;Relapse;Residual state;Resistance;resistance mechanism;response;Role;ROS1 gene;Sampling;Series;Shapes;Signal Transduction;single-cell RNA sequencing;small molecule;synthetic lethal interaction;System;targeted agent;targeted treatment;Technology;Testing;Therapeutic;therapy resistant;translational approach;Treatment Efficacy;tumor;tumor microenvironment;tumor xenograft;virtual

PROJECT_TITLE: Organoid Acquired Resistance


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Dental, Oral, and Craniofacial Disease;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: ROOTSTOWN

ORG_NAME: NORTHEAST OHIO MEDICAL UNIVERSITY

PHR: PROJECT NARRATIVE There are no targeted treatments for the dysregulated autonomic responses (‘dysautonomia’) of autism; yet, these disruptive physiologic responses that consist of alterations in heart rate, blood pressure, and perspiration affect over 70% of autistic individuals and contribute to significant disability. Building on a novel finding that the cerebellum, a brain region affected in autism, contains specific sites that control autonomic output, the proposed research will determine which cerebellar sites selectively influence autonomic physiologic responses and identify which sites are altered in a model of autism. Results are likely to advance our knowledge of the autonomic cerebellum and identify specific regions to therapeutically target for the dysautonomia prevalent in autism.

PI_NAMEs: SEESE, RONALD ROBERT (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TERMS: Adrenal Glands;Adrenal Medulla;Affect;Anatomy;animal facility;Animals;Area;autism spectrum disorder;autism symptoms;autistic children;Award;Behavior;Behavioral;Blood Pressure;Brain;Brain region;Budgets;Callithrix;Cerebellar vermis structure;Cerebellum;Clinical;clinical training;clinical translation;clinically relevant;Communities;Core Facility;Dedications;density;design;Development;disability;Disabling;Disease;Dysautonomias;Educational process of instructing;Ensure;Epinephrine;Exhibits;Exposure to;Extramural Activities;Faculty;faculty mentor;Family;Foundations;Funding;Galvanic Skin Response;Goals;graduate student;Heart Rate;Human;in vivo;individuals with autism spectrum disorder;innovative technologies;Institution;Knowledge;Length;Lobule;Location;Medical;member;Mentors;Mentorship;model of autism spectrum disorder;Molecular;Monkeys;multidisciplinary;neural network;Neuroanatomy;Neurobiology;Neurodevelopmental Disorder;Neurologist;Neurology;neuronal transport;neuroregulation;Neurosciences;nonhuman primate;novel;novel therapeutic intervention;novel therapeutics;Nurses;Ohio;Organ;Output;Patients;Pediatric Hospitals;Pediatrics;Peer Review;Peripheral;Physiological;prenatal exposure;prevent;Productivity;programs;Psychiatry;Publications;Rabies virus;Refractory;Research;Research Assistant;Research Training;Resources;response;Risk;Science;Secure;senior faculty;side effect;Site;skills;Source;square foot;System;targeted treatment;tenure track;Testing;therapeutic target;Transcranial magnetic stimulation;Translating;translational research program;Universities;Valproic Acid;Vision;waiver;Work

PROJECT_TITLE: Defining the Autonomic Cerebellum in Autism


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Genetics

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: The proposed research is relevant to public health because it will provide a high-content molecular imaging technology to visualize the molecular neighborhood of hundreds of genes to proteins used to perform widely deployed functions in cells and tissues. Normal cell cultures and tissues will be analyzed by the proposed technology to analyze how molecular neighbors operate in a specific role to affect a single cell's decision in intricate molecular crowds. Mathematical and theoretical analysis of these datasets will provide subcellular localization and neighborhood of protein and transcript molecules and their role in forming viable multicellular biological systems, an emerging spatially resolved subcellular regulation of health and disease.

PI_NAMEs: COSKUN, AHMET F. (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 3-Dimensional;Affect;Automobile Driving;Benchmarking;Bioinformatics;Biological Assay;biological systems;Biology;Biomanufacturing;Cell model;Cell Physiology;Cell Survival;Cells;Collaborations;Crowding;Data Analyses;Data Set;Disease;Environment;Epithelial Cells;Event;experience;Fluorescent in Situ Hybridization;Functional disorder;Gene Expression;Genes;Genetic;Genomics;Goals;Growth;Health;high throughput screening;Human;Image;Imaging technology;Individual;Intervention;Ligation;Mathematics;Measurement;Mesenchymal;Modeling;Molecular;Molecular Evolution;molecular imaging;molecular modeling;molecular scale;Neighborhoods;Normal Cell;Normal tissue morphology;Outcome;Pathology;Pharmaceutical Preparations;Phenotype;Population;Proliferating;Protein Analysis;Proteins;Public Health;Regulation;Research;Resolution;response;RNA;Role;Signal Transduction;Signaling Protein;small molecule;Specificity;Specimen;Stimulus;superresolution microscopy;System;Technology;tissue/cell culture;Tissues;Transcript;treatment response;Visualization;Work

PROJECT_TITLE: Dissecting subcellular and cellular organization by spatial molecular neighborhood networks

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Disability Research;Mental Health;Mental Illness;Psychosis;Schizophrenia;Serious Mental Illness;Substance Misuse

ORG_DEPT: PSYCHIATRY

PHR: Project Narrative The goal of this project is to test the prosocial compound ± 3,4-methylenedioxymethamphetamine (MDMA) as a novel treatment for a debilitating symptom of schizophrenia, impaired social motivation. This project will proceed in two phases; the aim of Phase 1 will be to establish the tolerability of MDMA in this patient population, and the aim of Phase 2 will be to test the effects of MDMA on social motivation. Results from these studies will be foundational in identifying effective psychopharmacologic and combined psychopharmacologic- psychosocial therapies for social deficits in schizophrenia.

PI_NAMEs: BERSHAD, ANYA K (contact)

PROJECT_TERMS: Acute;Address;Amphetamines;Antipsychotic Agents;Attention;attentional bias;Behavioral;behavioral pharmacology;biobehavior;Biological Psychiatry;Biostatistics Core;California;Center for Translational Science Activities;Clinical;Clinical Trials;Crossover Design;Cues;data management;debilitating symptom;Delusions;Department chair;Dose;ecstasy;effective therapy;Empathy;experience;Faculty;faculty mentor;Feeling;follow-up;Foundations;Functional impairment;Funding;Future;Goals;Grant;Hallucinations;healthy volunteer;Hormones;Hour;Human;Impairment;indexing;Individual;innovation;Institution;Intervention;Investigation;Journals;Laboratories;Lead;Los Angeles;Measures;meetings;Mental disorders;Mentorship;Methodology;Motivation;neuropsychiatry;neuropsychopharmacology;novel;open label;Oxytocin;Paper;Participant;patient population;Patient Self-Report;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Placebos;Plasma;Population;Positioning Attribute;Post-Traumatic Stress Disorders;professor;programs;Property;Psychiatry;psychopharmacologic;Psychopharmacology;psychosocial;psychostimulant;psychotic symptoms;Psychotropic Drugs;Publications;Publishing;randomized placebo controlled trial;Research;Research Design;Research Personnel;Schedule;Schizophrenia;Science;Secondary to;Secure;senior faculty;social;social attachment;social attention;social deficits;Social disability;social engagement;Social Functioning;Speech;symptom treatment;Symptoms;Testing;Therapeutic;Time;Universities;Work

PROJECT_TITLE: MDMA as a Treatment for Social Deficits in Schizophrenia


ADMINISTERING_IC: DA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Immunization;Neurosciences;Opioid Misuse and Addiction;Opioids;Prevention;Substance Misuse;Vaccine Related

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE An improved therapeutic method treating opioid overdoes is urgently needed, as the efficacy of naloxone is considered suboptimal due to the relative short half-life and inability to counteract opioid- induced pharmacological effects beyond the mu opioid receptor signaling pathway. The proposed study will investigate the evolution of B cell receptor repertoire in response to opioid use and vaccination, and combined with structure-based antibodies design, to delineate the B cell response against opioids and vaccination, and to generate opioid-specific monoclonal antibodies with improved affinity.

PI_NAMEs: ZHANG, YUE  (contact)

PROGRAM_OFFICER_NAME: MACDONALD, MARY THERESA

PROJECT_TERMS: Acceleration;Active Immunization;Address;Affinity;analog;Antibodies;Antibody Affinity;antibody engineering;Antibody Response;antigen binding;Antigens;B cell repertoire;B-Cell Antigen Receptor;B-cell receptor repertoire sequencing;B-Lymphocyte Subsets;B-Lymphocytes;Binding;Biomedical Research;blood-brain barrier crossing;Brain;career;cDNA Library;Circulation;Complex;Conjugate Vaccines;conventional therapy;COVID-19 pandemic;Data;Databases;design;Development;Diagnosis;Dose;Drug Targeting;Drug usage;Emergency Situation;Enrollment;Environment;Evolution;Fentanyl;fentanyl overdose;Flow Cytometry;Frequencies;Future;Generations;Genetic;Germ Lines;Goals;Half-Life;Heroin;Hospitalization;Human;human monoclonal antibodies;human subject;humanized monoclonal antibodies;Immunize;Immunoglobulin Somatic Hypermutation;improved;In Vitro;Individual;Knowledge;Laboratories;Lead;lead series;Libraries;Ligands;Lymphocyte;Mature B-Lymphocyte;Memory B-Lymphocyte;Methods;Monoclonal Antibodies;Morphine;mu opioid receptors;murine monoclonal antibody;Mus;Mutate;Mutation;Naloxone;naloxone dosing;next generation sequencing;novel therapeutics;Opioid;Opioid Antagonist;opioid overdose;opioid use;opioid use disorder;Overdose;overdose death;Oxycodone;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phase I Clinical Trials;Phylogenetic Analysis;polyclonal antibody;Population;prevent;prophylactic;psychostimulant;Research;Research Project Grants;response;Roentgen Rays;Sampling;Selection Bias;Series;Signal Pathway;single-cell RNA sequencing;Site-Directed Mutagenesis;skills;small molecule;Sorting;statistics;Structure;synthetic opioid;Testing;Therapeutic;Translations;unvaccinated;Vaccinated;Vaccination;vaccine-induced antibodies;Vaccines;Yeasts

PROJECT_TITLE: Immunoprofiling of Opioid Use Disorder Patients to inform structure-guided design of opioid-specific monoclonal antibodies


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Project Narrative The studies in this grant proposal address the cell signaling and survival mechanisms that rescue mitochondrial bioenergetic defects occurring in mitochondrial diseases. These mechanisms centered on mitochondrial ribosome translation and stalling/splitting, including the use of tetracyclines, have significant implications in mitochondrial diseases and age-associated diseases such as neurodegeneration.

PI_NAMEs: PUIGSERVER, PERE  (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Address;Affect;age-related disease;Aging;analog;Antibiotics;Applications Grants;Bioenergetics;biological adaptation to stress;Brain;Cell Death;cell injury;Cell model;Cell Survival;Cells;Cessation of life;Chemicals;Cytoprotection;Cytosol;Defect;Disease;DNA Sequence Alteration;Doxycycline;efficacy evaluation;Electron Transport;Endoplasmic Reticulum Degradation Pathway;endoplasmic reticulum stress;Energy Metabolism;Exhibits;expectation;Failure;fitness;Functional disorder;Generations;Genetic;Glycolysis;Goals;hallmarks of aging;Heat shock proteins;Heterogeneity;high throughput screening;Homeostasis;Human;human disease;Hypoxia;Immune;improved;Inflammation;Inflammatory;Intervention;Knockout Mice;Laboratories;Leigh Disease;Link;link protein;MAP Kinase Gene;Measures;Mediating;Messenger RNA;Mitochondria;Mitochondrial complex I deficiency;Mitochondrial Diseases;mitochondrial dysfunction;Mitochondrial Proteins;Molecular;mouse model;mTOR inhibition;Mus;mutant;Mutation;Nature;Nerve Degeneration;Nutrient;Outcome;Outcome Study;Oxidation-Reduction;Oxidative Phosphorylation;p38 Mitogen Activated Protein Kinase;Pathogenicity;Patients;Phenotype;Pre-Clinical Model;protective efficacy;Protein Kinase;Proteins;Proteomics;response;Ribosomes;Series;Severities;Signal Transduction;Skeletal Muscle;Stress;Tetracyclines;Tissues;Transcript;transcription factor;Translational Repression;Translations

PROJECT_TITLE: Mitoribosome protein translation signaling and survival mechanisms

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative: To combat diseases, it is essential to study the function of biomolecules to understand the underlying disease mechanisms. Multi-frequency Electron Spin Resonance (ESR) spectroscopy, which is a powerful method to study functional dynamics of proteins, lacks sufficient sensitivity and resolution to carry out studies at physiological concentrations and longer time scales. The proposed research will develop computational methods to improve signal resolution in ESR spectroscopy, enabling better understanding of disease mechanisms for more effective therapies, thus benefiting the public health.

PI_NAMEs: SRIVASTAVA, MADHUR  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Address;Adopted;Biological;biological systems;biophysical techniques;combat;Complex;computerized data processing;Computing Methodologies;data acquisition;denoising;Development;Dimensions;Disease;drug development;Early Diagnosis;effective therapy;Electron Spin Resonance Spectroscopy;Environment;Foundations;Frequencies;frontier;improved;instrument;Knowledge;Lipids;Measurement;Membrane;Methods;Molecular Conformation;Motion;Muramidase;Noise;Physiological;Play;Protein Conformation;Protein Dynamics;Proteins;Public Health;Recovery;Research;Resolution;Signal Pathway;signal processing;Signal Transduction;Structure;Temperature;Time;Uncertainty

PROJECT_TITLE: Room Temperature Protein Conformational Dynamics at Microsecond Timescales


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE The build-up of tau protein in the brain closely tracks with symptoms of Alzheimer’s Disease (AD) and can be measured with specialized Positron Emission Tomography (PET) brain scans and blood tests; new treatments that reduce tau are predicted to produce greater clinical benefits than currently approved AD drugs. This study will test the ability of two tau therapies to reduce brain tau levels either alone or in combination with a drug that reduces amyloid protein in patients with very early AD. Using an efficient clinical trial design adapted from cancer research, the study will identify whether either tau therapy by itself or in combination with an anti-amyloid drug is promising enough to be tested in future large studies to determine meaningful clinical benefit, as well as whether blood tests for tau could reduce the need for expensive PET scans in future clinical trials.

PI_NAMEs: BOXER, ADAM L. (contact);JOHNSON, KEITH A.

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: abeta accumulation;Acceleration;Address;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease therapeutic;Alzheimer's disease therapy;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Amyloid Proteins;Anatomy;anti-cancer research;arm;Autopsy;Biological;Biological Markers;Biology;Blinded;Blood Tests;Brain;Brain scan;Chemotherapy-Oncologic Procedure;Clinic;Clinical;Clinical assessments;clinical development;clinical trial protocol;Clinical Trials;Clinical Trials Design;Combined Modality Therapy;Data;Decision Making;Dementia;Deposition;design;Disease;Disease Progression;efficacy study;efficacy trial;Enrollment;experience;Failure;Future;Gene Mutation;Generations;Goals;improved;inclusion criteria;Individual;Inherited;Intervention;Life;Light;Magnetic Resonance Imaging;Measures;Nerve Degeneration;Neurodegenerative Disorders;neurofilament;New Agents;novel strategies;novel therapeutic intervention;Oncology;open label;Outcome;Participant;Pathogenicity;Patients;PET positivity;Pharmaceutical Preparations;Pharmacodynamics;Phase;Placebo Control;placebo group;Placebos;Plasma;Positron-Emission Tomography;pre-clinical;prodromal Alzheimer's disease;programs;Randomized;recruit;Regimen;Resources;Safety;safety testing;Sampling;secondary analysis;secondary endpoint;Severity of illness;Signal Transduction;Site;Sum;Symptoms;Syndrome;targeted agent;tau aggregation;tau mutation;tau Proteins;tau-1;Temporal Lobe;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Time;tool;Tracer;treatment effect;United States National Institutes of Health;uptake

PROJECT_TITLE: The Alzheimer's Disease Tau Platform Clinical Trial

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-T(02)M]


NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

PHR: Project Narrative The aim of the proposed research is to test the impact of a primary care-based intervention to prevent obesity in low-income Latino infants and toddlers. Latino children are at high risk of obesity and other diseases linked to obesity including type 2 diabetes. The goal of this study is to learn how to best promote health behaviors in early life that will result in lower risk of obesity in childhood and across the lifespan.

PI_NAMEs: BECK, AMY LAURA (contact)

PROGRAM_OFFICER_NAME: WALKER, JENELLE ROSE

PROJECT_TERMS: acceptability and feasibility;Acculturation;Address;Age;attentional control;Behavior;behavior change;Behavioral;Beverages;Birth;Body mass index;Breast Feeding;California;Caregivers;Child;Child Health;Childhood;Clinical;Consumption;dietary;Dietary Practices;Disease;Disparity;early childhood;experience;Family;Family Caregiver;Family Characteristics;Family member;family structure;fatty liver disease;feeding;Feeding behaviors;Food;Food Selections;Fruit;fruits and vegetables;Future;Goals;Guidelines;Health;Health behavior;Health education;Health Educators;Health Personnel;Health Promotion;high risk;Home;Hypertension;improved;infancy;Infant;Intake;Intervention;intervention cost;intervention effect;intervention participants;Interview;Juice;Language Development;Latino;Learning;Life;life span;lifetime risk;Link;Low income;Low Income Population;Mediating;Mediation;Mediator;Metabolic;Modality;Modeling;modifiable risk;Modification;Motivation;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Nurses;Nutritionist;Obesity;obesity in children;obesity prevention;obesity risk;obesogenic;Outcome;Parents;Pattern;Persons;Physicians;pilot test;pilot trial;Population;Poverty;Primary Care;primary care clinic;primary care setting;primary care visit;primary outcome;Provider;Public Health;Qualitative Methods;Randomized;Recommendation;recruit;reinforced behavior;Research;Resources;response;Risk;Risk Factors;Role;Safety;secondary outcome;sedentary lifestyle;Site;skills;Sleep;sleep behavior;Structure;Study models;sugar;sweetened beverage;Techniques;Technology;Testing;Text Messaging;text messaging intervention;Toddler;trend;tv watching;United States;Visit;Weight;Well Child Visits

PROJECT_TITLE: Futuros Fuertes 2.0: A primary care-based intervention to prevent obesity in low-income Latino children

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ORG_CITY: SAINT LOUIS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narratives (Public Health Relevance) An outstanding mystery in embryo development is how cells sense and respond to tissue-scale changes. We propose that cells are integrating both biochemical and mechanical signals to accurately sense tissue information in order to make reliable decisions to control tissue development. The proposed experiments will reveal mechanochemical crosstalk mechanisms that address fundamental questions in development, explain disease pathologies such as birth defects and cancer, and inspire novel strategies to improve the consistency of artificial tissues for therapeutic applications.

PI_NAMEs: TSAI, TONY YU-CHEN (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Address;Adhesions;Artificial tissue;Biochemical;Cadherins;Cell Adhesion;cell type;Cells;Computer Models;Congenital Abnormality;Development;Developmental Biology;Disease;disease model;embryo tissue;Embryonic Development;empowerment;Engineering;Environment;Event;experimental study;Genetic;Image;improved;In Vitro;in vivo;Individual;innovation;Malignant Neoplasms;mechanical force;mechanical signal;Mechanics;Morphogenesis;morphogens;multidisciplinary;novel;novel strategies;Pathology;Pattern;Positioning Attribute;programs;public health relevance;Research;response;Shapes;Signal Pathway;Signal Transduction;Testing;Therapeutic;Tissue Engineering;Tissues;tool;Work;Zebrafish

PROJECT_TITLE: Principles of Mechanochemical Signal Integration Underlying Developmental Robustness


ORG_CITY: PETERSBURG

ORG_DEPT: BIOLOGY

ORG_NAME: VIRGINIA STATE UNIVERSITY

ORG_STATE: VA

PHR: OVERALL: PROJECT NARRATIVE The overarching goal of the Virginia State University (VSU)-Virginia Commonwealth University (VCU) Massey Cancer Center (MCC) PartnErship for CancEr Disparities Research and Training (SUCCEED) program is to lead in the transformation of cancer-related outcomes for Virginians and to serve as a model of transdisciplinary disparities research. The institutions will jointly conduct pilot research projects addressing local, cancer-related health disparities and will develop a training program for VSU faculty and undergraduate students designed to attract and prepare investigators for careers in cancer disparities.

PI_NAMEs: FAISON, MILTON O (contact);ROBERTS, DANIEL M.

PROGRAM_OFFICER_NAME: RODRIGUEZ, LARITZA MARIA

PROJECT_TERMS: Address;Affect;African American;anti-cancer research;Black Populations;Black race;Cancer Burden;Cancer Center;cancer health disparity;career;career development;Cause of Death;Collaborations;Colorectal Cancer;Communities;community partnership;Comprehensive Cancer Center;Data;Death Rate;design;Development;Diagnosis;Disease;Disparity;Economics;Education;Elements;Emotional;Evaluation;experience;Faculty;Family;Fostering;Funding;Funding Agency;Goals;Growth;Health;Health Disparities Research;health disparity;health inequalities;Historically Black Colleges and Universities;Individual;Infrastructure;Institution;Intervention;Journals;K-Series Research Career Programs;Knowledge;Lead;Liver;Localized Malignant Neoplasm;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Massey Cancer Center at the Virginia Commonwealth University;meetings;member;Mentors;minority investigator;minority undergraduate;Modeling;mortality;multidisciplinary;Nature;neoplasm registry;Outcome;Output;Pattern;Peer Review;Phase;Pilot Projects;Positioning Attribute;Prevention;programs;Publications;Recording of previous events;Research;Research Activity;Research Personnel;Research Project Grants;research study;Research Support;Research Training;Resources;rural dwellers;science education;Social Well-Being;statistics;Students;summer research;survivorship;Testing;Training;Training Activity;Training and Education;Training Programs;undergraduate student;Underrepresented Minority;Universities;Virginia;Vision;Vital Statistics

PROJECT_TITLE: 2/2 VSU-MCC Partnership for Cancer Disparities Research and Training program (SUCCEED)


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: FAISON, MILTON O (contact)

PROJECT_TERMS: Advisory Committees;Animals;anti-cancer research;Cancer Center;cancer health disparity;Communication;Data;Doctor of Philosophy;Education Projects;education research;Educational workshop;Ensure;Environment;Evaluation;Expenditure;Funding;Future;Goals;Grant;Human Resources;human subject;Institution;Institutional Review Boards;Interruption;Leadership;meetings;member;Mission;Modeling;Monitor;Policies;pressure;Principal Investigator;Problem Solving;programs;Progress Reports;Publications;Research;Research Project Grants;Resource Allocation;Resources;Safety;Strategic Planning;System;timeline;Training;Training Programs;Universities;Virginia

PROJECT_TITLE: SUCCEED Administrative Core


NIH_SPENDING_CATS: Cancer

PHR: Narrative  The overall objective of this Training Program is to prepare the next generation of leaders in Medical Oncology in laboratory and clinical translational sciences. The program will provide outstanding mentored laboratory and clinical investigation research experiences from senior and experienced junior faculty and support for the recruitment and mentorship of under-represented minority fellows. It is expected that at the conclusion of their training, individuals supported by this training program will have the ability to design, initiate, and complete individual clinical or laboratory research projects, will be able to function independently or with minimal supervision, and will be positioned to soon establish themselves as independent research investigators.

PI_NAMEs: BROWN, JENNIFER R;DECAPRIO, JAMES A. (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TITLE: Physician Scientist Training in Cancer Research


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: DALLAS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative  Viral infections continue to pose significant economic and public health challenges worldwide, yet we still only poorly-understand the host defenses that inhibit viral replication and the immune evasion proteins (IEPs) employed by viruses to counter these host responses. Here we take a unique approach to identify IEPs encoded by mammalian pathogens that target evolutionarily-conserved antiviral host machinery by screening for IEPs that suppress antiviral immune responses in both insect and human cells. We will use these pathogen-encoded IEPs to identify and characterize the conserved host machinery they target and ultimately leverage this information to develop new strategies to defeat IEP function and block viral infection.

PI_NAMEs: GAMMON, DON BRAD (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Arbovirus Infections;Arboviruses;Area;arms race;Bacteria;Binding;Biochemical;Butterflies;Cell Physiology;Cells;Chromatin;Complex;Cytoplasm;Economics;Equilibrium;Family;Genetic;Genetic Transcription;Histones;Host Defense;host-pathogen coevolution;Human;Immune Evasion;Immune response;Immunosuppression;Infection;Insecta;insight;Integration Host Factors;Invertebrates;Mammals;Mission;Modeling;Modification;Molecular Chaperones;Moths;novel;novel strategies;Outcome;pathogen;pathogenic bacteria;Post-Translational Protein Processing;Poxviridae;Poxviridae Infections;Predisposition;prevent;Productivity;protein function;Proteins;Public Health;RNA Viruses;Role;screening;Screening procedure;System;Viral;Viral Physiology;Virus;Virus Diseases;virus host interaction;Virus Replication

PROJECT_TITLE: Exploiting Pathogen-Encoded Immune Evasion Proteins to Uncover Evolutionarily Conserved Antiviral Host Machinery


NIH_SPENDING_CATS: Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Signal transduction networks are the information processing engines of the cell, and their dysregulation leads to many human diseases. Despite their fundamental importance, little is understood about how signaling networks vary across individuals and human populations, and how this variation interacts with pathogenic mutations to drive disease. We will develop a research program focused on developing computational tools to predict protein- ligand interactions in signaling networks and applying them to large-scale genomic datasets to investigate variability and dysregulation of human cell signaling.

PI_NAMEs: ALQURAISHI, MOHAMMED NAZAR (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Address;Affinity;Alleles;Amino Acid Sequence;biobank;Biological;Cells;Chemicals;Collaborations;Computer Models;computerized tools;deep learning;Disease;exome;genetic analysis;Genetic Diseases;Genome;genomic data;Human;Human Biology;human disease;Individual;Information Networks;information processing;Language;Learning;Ligand Binding;Ligands;Machine Learning;machine learning model;Maps;mathematical learning;Modeling;Mutation;National Heart, Lung, and Blood Institute;Pathogenicity;Pathway interactions;Persons;Population;predictive modeling;programs;Property;Protein Conformation;protein protein interaction;protein structure prediction;Proteins;Proteome;Research;Signal Transduction;Structure;synergism;Systems Biology;Techniques;Testing;trait;Trans-Omics for Precision Medicine;Variant

PROJECT_TITLE: Machine learning of biomolecular interactions and the human signaling networks they comprise

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Clinical Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The state of Connecticut identifies “spikes,” or sudden increases in opioid overdoses and issues “spike alerts” to first responders, harm reduction organizations and health systems in order to help mount a rapid and effective public health response to curtail overdose rates and minimize fatalities. It is unclear if these alerts affect overdose rates, how alerts are used to guide public health responses in practice and if there are modifications to the system or alternative systems that would more effectively motivate responses to overdose spikes. To this end, I will 1) evaluate the causal effect of CT's spike response framework on overdoses, 2) survey harm reduction organizations, first responders and other healthcare workers to understand their use of the system, barriers they face when responding to overdoses and preferred modifications or alternatives to the existing system 3) develop an alternative to the current system based on survey feedback and simulate its effect, along with that of other preferred modifications and alternatives, on overdose rates, all with the aim of helping reduce overdose rates and subsequent deaths in Connecticut.

PI_NAMEs: RAM, ARCHANA  (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Accounting;Address;Affect;Benzodiazepines;career;Cessation of life;Cocaine;Communities;Connecticut;Country;Data;data integration;Data Sources;Detection;Doctor of Philosophy;Effectiveness;epidemiological model;Evaluation;Event;evidence base;experience;Face;Feedback;Fentanyl;first responder;Funding;Future;Goals;Harm Reduction;Health;Health Personnel;Health system;Healthcare Systems;Heroin;Hour;improved;Individual;Injury;innovation;Intervention;Manuals;Maps;Mentorship;Methods;Modeling;Modification;novel;opioid epidemic;opioid overdose;opioid use;Outcome;Overdose;overdose death;overdose prevention;Overdose reduction;Persons;Policies;prevent;programs;Provider;Public Health;Reporting;response;Rest;Series;Source;statistics;Street Drugs;Surveys;synthetic opioid;System;Techniques;Testing;theories;Time;Training;trend;Work

PROJECT_TITLE: Innovations in Modeling Existing and Emerging Policies to Improve Warning Systems for Opioid Overdoses

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-E(20)L]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative: RNA structure is important in both human health and disease, including genetic diseases and infectious diseases. Here we are developing algorithms and software to predict and analyze RNA structure. This provides important information that can be used to understand disease mechanisms, target RNA with pharmaceuticals, and develop RNA-based pharmaceuticals.

PI_NAMEs: MATHEWS, DAVID H. (contact)

PROJECT_TITLE: RNA Structure Modeling Using Physics and Sequence Comparison


NIH_SPENDING_CATS: Bioengineering;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Genetics;Immunotherapy;Nanotechnology;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: ATLANTA

ORG_DEPT: NEUROSURGERY

ORG_NAME: EMORY UNIVERSITY

PHR: Glioblastoma is a brain tumor that cannot be cured with standard treatments (which include surgery, chemotherapy, and radiation), so patients with these tumors need new therapies that may work better. A type of genetic material in cancer patient immune cells differs from the immune cells of healthy people. By studying this genetic material, called long non-coding RNAs, in glioblastoma patient immune cells, we can help these cells attack brain tumors.

PI_NAMEs: NDUOM, EDJAH  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Acceleration;Affect;base;bioinformatics tool;Brain Neoplasms;Cancer Patient;cancer therapy;candidate identification;CD14 gene;Cell Physiology;cell type;Cells;chemotherapy;clinical development;Clinical Trials;Data;Development;differential expression;Disease Progression;Flow Cytometry;Future;Genetic Materials;Genetic study;Genetic Transcription;Genetically Engineered Mouse;Glioblastoma;Goals;Immune;Immune response;Immune system;Immunologic Stimulation;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;improved outcome;Infiltration;innovation;Interleukin-13;Interleukin-4;Intracranial Neoplasms;Knowledge;Literature;Macrophage;Magnetic Resonance Imaging;Malignant neoplasm of brain;Mediating;Modeling;monocyte;mouse model;Mus;Myeloid Cells;nanoparticle;nanoparticle delivery;neoplastic cell;novel;novel therapeutics;Operative Surgical Procedures;Outcome;overexpression;Patient-Focused Outcomes;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Population;pre-clinical;Radiation;Research;Resistance;response;Science;Small Interfering RNA;Sorting;standard care;Suspensions;theranostics;Therapeutic;therapeutic target;Tissues;transcriptome sequencing;Treatment Efficacy;treatment strategy;tumor;tumor progression;Tumor Promotion;Tumor-associated macrophages;tumor-immune system interactions;Untranslated RNA;Work

PROJECT_TITLE: Macrophage-targeted lncRNA-regulating nanoparticles for glioblastoma treatment

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Bioengineering;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: PISCATAWAY

ORG_DEPT: CHEMISTRY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Next-generation alchemical free energy methods and quantum/machine-learning  models for drug discovery. PI: Darrin M. York, Rutgers University, Piscataway, NJ 08854-8087 USA.  The current proposal addresses a critical barrier to progress in drug discovery: limitations in precision and accuracy of alchemical free energy simulations for prediction of ligand-protein binding afﬁnities. Speciﬁcally, new advanced technologies are proposed to enhance precision in alchemical free energy simulations, and a new quantum mechanical/deep-learning potential force ﬁeld is developed to improve accuracy of binding afﬁnity predictions. Methods and models will be carefully validated against several targets in collaboration with both academic and industry researchers.

PI_NAMEs: YORK, DARRIN M (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: 2019-nCoV;Academia;Acceleration;Address;Affinity;base;Bathing;Benchmarking;Binding;Binding Proteins;Books;Chemicals;Collaborations;Complex;Computer software;cost;Data;Data Set;deep learning;density;design;drug discovery;Drug Modelings;drug-like compound;Electronics;Electrostatics;experience;Family;Fluorescence Polarization;Free Energy;Goals;Government;Graph;improved;Individual;Industry;inhibitor;insight;intermolecular interaction;Ions;JAK2 gene;Lagrangian multiplier;Libraries;Ligand Binding;Ligands;Machine Learning;machine learning model;Maps;Measurement;mechanical energy;member;Methods;Migration Inhibitory Factor;Modeling;Molecular;Molecular Chaperones;molecular mechanics;new technology;next generation;Pathway interactions;Phase;Proteins;protonation;quantum;Quantum Mechanics;receptor;Reproducibility;Research Personnel;response;Role;Sampling;SARS-CoV-2 variant;scaffold;Series;simulation;Solvents;Structure;System;tautomer;Technology;Testing;Therapeutic;Thermodynamics;tool;Training;Universities;Validation;validation studies;Water;Work

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Project Narrative Blood-brain barrier (BBB) deterioration is an important feature of Alzheimer’s disease (AD) and vascular cognitive impairment (VCI) that frequently precedes cognitive symptoms, yet the process is poorly understood and as a result there are currently no protective treatments. I have established a novel role of the prostaglandin degrading enzyme 15-PGDH in protecting the BBB in a mouse model of AD, and am expanding the study to a VCI model in the F99 phase of this project. During the subsequent K00 phase, I will incorporate the role of metabolic changes of perivascular macrophages in regulating BBB health by interacting with endothelial cells, in order to provide new insight into the discovery and development of neuroprotective opportunities for patients suffering from AD and VCI.

PI_NAMEs: KOH, YEO JUNG  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Address;Affect;Aging;aging population;aging related;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyloid;Animal Model;Area;axonal degeneration;beta amyloid pathology;Biology;Blood - brain barrier anatomy;Blood Vessels;Brain;brain endothelial cell;brain health;career;Caregivers;Cell Communication;Cognitive deficits;Communication;cost;Creativeness;Data;Dementia;Deterioration;Development;Economic Burden;effective therapy;efficacy evaluation;Electron Microscopy;Endothelial Cells;Enterobacteria phage P1 Cre recombinase;Enzymes;Experimental Designs;extend lifespan;Foundations;Future;Gene Expression Profile;Genetic;glucose metabolism;Glycolysis;Goals;Health;High Fat Diet;Hippocampus;Human;Image;Immune;Immune system;Immunology;Impairment;improved;In Vitro;in vivo;in vivo imaging;in vivo Model;Inflammatory;innovation;insight;interest;International;Laboratories;Learning;Life;life span;Literature;Macrophage;Mediating;Medical;Medical Research;medical schools;Medicine;Mentorship;Metabolic;Metabolism;Microglia;Modeling;mouse model;Mus;Nerve Degeneration;Neurobehavioral Manifestations;neurogenesis;neuroprotection;Neurosciences Research;neurovascular;neurovascular unit;new therapeutic target;normal aging;novel;Oxidoreductase;Pathologic;Pathology;Patients;Peripheral;pharmacologic;Phase;post-doctoral training;Postdoctoral Fellow;preservation;Prevalence;prevent;Process;Prostaglandin D2;Prostaglandins;protective effect;protective efficacy;Research;Research Activity;Research Project Grants;research study;Risk Factors;Rodent Model;Role;Scientist;Senile Plaques;skills;socioeconomics;symposium;System;Testing;Thinking;Time;Transcript;transcriptomic profiling;Treatment Efficacy;two photon microscopy;two-photon;United States;Vascular Cognitive Impairment;Vascular Dementia;Vascular System;Work

PROJECT_TITLE: Mechanisms of blood-brain barrier deterioration in vascular cognitive impairment and Alzheimers disease


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: BETHESDA

ORG_NAME: PREVEP, INC.

ORG_STATE: MD

PHR: PHR Status epilepticus (SE) and refractory status epilepticus (RSE) continue to be medical emergencies and more effective treatments for rapid seizure control are needed. The goal of this preclinical SIR application is to test tolerability, safety, and efficacy of the novel intravenous formulation of topiramate in a clinically relevant rat model of RSE. The expected outcome of this work is to generate data for a pre-IND meeting to enable the future conduct of a phase I and Ila program and to enable the first-in-human proof of concept study of intravenous topiramate.

PI_NAMEs: KLEIN, PAVEL  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, FLOY ANNETTE

PROJECT_TERMS: 12 year old;Address;Age;age group;Anticonvulsants;Benzodiazepines;Biology;Blinded;Blood;Brain;Chemicals;Child;Clinical;Clinical Trials;clinically relevant;cohort;Complex;Cyclodextrins;Data;design;Development;Diazepam;Dose;Drug Kinetics;Drug vehicle;effective therapy;Elderly;Electroencephalography;Enteral;Etiology;Excipients;experimental study;FDA approved;Female;first-in-human;Formulation;fosphenytoin;Funding;Future;GABA Receptor;gamma-Aminobutyric Acid;Gastrointestinal Surgical Procedures;Glutamate Receptor;Goals;healthy volunteer;high risk;Hour;Impairment;improved;Injectable;Injections;Intellectual Property;intraperitoneal;Intravenous;intravenous administration;Kidney;Legal patent;Levetiracetam;Lithium;male;manufacturing process;Measures;Medical;Medical emergency;Meglumine;Migraine;Modeling;Monitor;Morbidity - disease rate;mortality;multimodality;nephrotoxicity;Nervous System Trauma;Neurologic;Neurological emergencies;neuroprotection;novel;Oral;Outcome;oxidation;parenteral administration;Patients;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Photophobia;Pilocarpine;Plasma;pre-clinical;pre-Investigational New Drug meeting;prevent;Program Development;programs;Randomized;Rattus;Recurrence;Refractory;Replacement Therapy;research clinical testing;Resistance;Risk;Rodent;Role;Route;Safety;Sampling;Sedation procedure;Seizures;Signal Transduction;Site;Small Business Innovation Research Grant;Sodium Channel;Status Epilepticus;systemic toxicity;Temperature;Testing;Therapeutic;Time;topiramate;Toxic effect;Treatment outcome;treatment trial;Tube;United States National Institutes of Health;valproate;voltage;volunteer;Work;young adult

PROJECT_TITLE: Treatment of status epilepticus and refractory status epilepticus with intravenous topiramate.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-P(11)B]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Genetics;Infectious Diseases;Lung;Orphan Drug;Rare Diseases

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Narrative Non-tuberculous mycobacteria (NTMs) cause infections that often result in chronic disease that is near impossible to cure and extremely difficult to treat. This project aims to identify and characterize specific interactions that result in innate drug resistance and treatment failure in NTMs. This work could lead to development of specific inhibitors that would effectively treat these notoriously difficult pathogens.

PI_NAMEs: ROCK, JEREMY MICHAEL;RUBIN, ERIC J. (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Anti-Bacterial Agents;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Biological;Cells;chemical genetics;Chronic Disease;chronic infection;Clinical;Data;Defect;Development;drug development;Drug resistance;Environment;Genes;Genetic;genetic approach;Genetic Screening;Genetic Variation;Goals;Growth;Host Defense;Human;Immune;Infection;inhibitor;Investments;Lung Diseases;Lung infections;Measures;Modeling;Molecular;Mutation;mycobacterial;Mycobacterium abscessus;Mycobacterium avium Complex;Mycobacterium tuberculosis;non-tuberculosis mycobacteria;Organism;pathogen;Pathway interactions;Patients;Penetration;Pharmaceutical Preparations;Pharmacotherapy;Phylogenetic Analysis;Population;Predisposition;Resistance;resistance mechanism;screening;therapeutic target;Time;tissue culture;tool;Toxic effect;Treatment Failure;treatment response;tuberculosis treatment;Work

PROJECT_TITLE: Molecular mechanisms of inherent drug resistance in non-tuberculous mycobacteria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIRT-J(01)]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE Glioblastomas are the most common and deadly malignant tumors of the central nervous system, and are incurable with current therapies. In this application, we propose to test the therapeutic relevance of the YAP and TAZ transcriptional effectors and to test the efficacy and mechanisms of action of the FDA-approved drug and YAP/TAZ inhibitor verteporfin in pre-clinical human cortical organoid glioblastoma models, in animal models of glioblastoma, and in human patient specimens. If successful, this project will establish a basis for repurposing verteporfin as a treatment for GBM.

PI_NAMEs: READ, RENEE D (contact)

PROJECT_TERMS: absorption;Adhesions;Adult;angiogenesis;Angiogenesis Inhibitors;Animal Model;Apoptosis;bevacizumab;Binding;blood-brain barrier crossing;Brain;Brain Neoplasms;c-myc Genes;Cell Communication;Cell Death;Cell Physiology;Cell Survival;Cells;Clinical;clinical trial participant;Clinical Trials;cofactor;Data;Dependence;DNA;Dose;Drug Targeting;Edema;efficacy testing;Epidermal Growth Factor Receptor;Epigenetic Process;epigenomics;FDA approved;Fluorescence Spectrometry;Gene Expression;Genes;Genetic;Genetic Transcription;Glioblastoma;Glioma;Goals;Growth;Human;Immunocompetent;Immunosuppression;inhibitor;insight;liposomal formulation;Liposomes;Macular degeneration;Malignant - descriptor;Malignant Glioma;Malignant neoplasm of brain;Malignant neoplasm of central nervous system;Mass Spectrum Analysis;Mediating;Metabolism;migration;Modeling;mouse genetics;mouse model;Mus;mutant;Mutation;Neoplasms;neoplastic cell;nerve stem cell;neural;Neuroglia;Oncogenic;Organoids;overexpression;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phase 0 Clinical Trial;Phase I/II Clinical Trial;Phosphotransferases;PIK3CG gene;pre-clinical;Primary Brain Neoplasms;Process;programs;Proliferating;protein expression;Proteins;Proto-Oncogene Proteins c-myc;Receptor Protein-Tyrosine Kinases;Recurrence;Resistance;response;response biomarker;self-renewal;Signal Pathway;Signal Transduction;Specimen;Stable Disease;stem cell self renewal;stem cells;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;therapeutic target;Transcription Coactivator;transcriptomics;Translational Research;tumor;tumor diagnosis;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Stem Cells;Tumorigenicity;uptake;Vascular Endothelial Growth Factors;Verteporfin;Visualization;Xenograft Model

PROJECT_TITLE: Verteporfin as a YAP/TAZ inhibitor for treatment of glioblastoma

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Radiation Oncology

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE Sequential therapy of solid tumors with tumor targeted radiation therapy followed by untargeted immune therapy has shown promise in the clinic. This approach can be further improved by using targeted immune therapy and studying the immune response on tumor biopsies taken before and after therapy. Using a combination of clinical and animal model data, we will refine the therapeutic doses and identify the best predictive markers of response to therapy.

PI_NAMEs: SHIVELY, JOHN ERNEST (contact);WONG, JEFFREY Y;YAZAKI, PAUL

PROGRAM_OFFICER_NAME: VIKRAM, BHADRASAIN

PROJECT_TERMS: Animal Model;Animals;Antibodies;Antigen Targeting;Beta Particle;Biopsy;Blocking Antibodies;Blood Platelets;Body Weight decreased;Breast;Carcinoembryonic Antigen;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;checkpoint therapy;Clinic;Clinical;Clinical Research;Clinical Trials;clinically relevant;Colon;Colonic Neoplasms;Combined Modality Therapy;comparative;Correlative Study;cytokine;Data;data modeling;design;Dose;dosimetry;effector T cell;Environment;Eragrostis;FDA approved;fibroblast-activating factor;Fibroblasts;FOXP3 gene;Funding;Future;Hematology;IL2 gene;Image;image guided radiation therapy;Immune;immune activation;immune cell infiltrate;Immune response;Immune Targeting;Immunize;Immunocompetent;Immunologics;immunoregulation;Immunotherapy;improved;Infiltration;Interleukin-2;Length;Linear Energy Transfer;Lymphocyte;Malignant Neoplasms;man;Maximum Tolerated Dose;Measurement;Mental Depression;Modeling;Monitor;Mus;Myelogenous;Neoplasm Metastasis;Normal tissue morphology;Patients;Phase;Phenotype;Plasma;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;predictive marker;Property;Proteins;Radiation;Radiation therapy;Radionuclide therapy;Regimen;Regulatory T-Lymphocyte;Resistance;response;Safety;Shapes;side effect;Site;Solid Neoplasm;Spleen;Stromal Cells;Stromal Neoplasm;Study models;subcutaneous;systemic toxicity;targeted therapy trials;Testing;Therapeutic;Therapy trial;Time;Tissues;Toxic effect;Transgenic Mice;treatment response;treatment strategy;tumor;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;wound healing

PROJECT_TITLE: Targeted radiation and immunocytokine therapy for CEA positive malignancies

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: CINCINNATI

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: PROJECT NARRATIVE This proposal is centered around determining the role of an RNA binding protein, HuR, in cardiac fibrosis. Preliminary data suggests that HuR is involved in the propagation of pathological fibrosis through stabilizing the upregulation of extracellular matrix proteins. Therefore, we believe a fibroblast specific deletion of HuR will be cardio-protective and further HuR as a therapeutic target.

PI_NAMEs: PARKINS, SHARON  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Binding;Cardiac;Cardiac Myocytes;cardioprotection;cell type;connective tissue growth factor;coronary fibrosis;Data;Development;Extracellular Matrix;Extracellular Matrix Proteins;Fibroblasts;Fibrosis;Future;Gene Expression;Genes;Goals;heart function;heart preservation;Homeostasis;Hour;HuR protein;In Vitro;in vitro activity;in vivo;knock-down;loss of function;Mediating;Mediator;mouse model;Mus;Myofibroblast;novel;overexpression;Pathologic;periostin;pharmacologic;Phenotype;Play;pressure;Publishing;Recombinants;Regulation;Resolution;response;RNA-Binding Proteins;Role;Signal Transduction;Small Interfering RNA;Therapeutic;therapeutic target;Transforming Growth Factor beta;Translations;Untranslated RNA;Up-Regulation;Variant;Work

PROJECT_TITLE: HuR-Wisp1 signaling in cardiac fibroblasts


ADMINISTERING_IC: AT

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Chronic Pain;Complementary and Integrative Health;Neurosciences;Pain Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE Music-based interventions are receiving increasing attention for their promising effects on acute pain and chronic pain. Although the pain-relieving effects of music-based interventions are well- established, lack of understanding of how music affects pain prevents us from exploiting their full therapeutic potential. The purpose of the Music4Pain Network is to establish a multidisciplinary research network to support innovative research aimed at advancing mechanistic understanding of music for pain.

PI_NAMEs: BRADT, JOKE  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEN G

PROJECT_TERMS: Acceleration;Acute Pain;Adoption;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;American;Applications Grants;Area;Attention;Behavioral Medicine;biomarker identification;Board Certification;career;chronic pain;clinical care;cognitive neuroscience;Collaborations;Collection;cost;Data;design;Development;Discipline;doctoral student;Extramural Activities;forging;Funding;Goals;Health Care Costs;Health Personnel;improved;innovation;Institution;interdisciplinary approach;Interdisciplinary Study;Intervention;Knowledge;Medicine;meetings;member;Mentors;Methodology;multidisciplinary;Music;Music Therapy;musician;neural;Neuropsychology;Nonpharmacologic Therapy;outreach;Pain;Pain management;pain perception;pain relief;Pain Research;Participant;Patients;Persons;Pilot Projects;pleasure;Positioning Attribute;Postdoctoral Fellow;Prediction of Response to Therapy;predictive marker;prevent;Productivity;programs;Psychology;recruit;Rehabilitation therapy;Research;Research Personnel;Research Priority;Resource Sharing;Rewards;Scholars Program;Scientist;skills;social media;special interest group;Specialist;Speed;symposium;System;Taxonomy;Therapeutic;Therapeutic Effect;therapy development;Training;training opportunity;treatment response;United States National Institutes of Health;visiting scholar;web site;webinar;Work;working group

PROJECT_TITLE: Music4Pain Network: A research network to advance the study of mechanisms underlying the effects of music and music-based interventions on pain.


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Sleep Research;Substance Misuse

ORG_CITY: Riverside

ORG_NAME: EMMA PENDLETON BRADLEY HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE  The opioid epidemic in the US continues at a cost of over $1.5T and over 75,000 deaths annually. Poor sleep is a major risk factor that both influences opioid problems and is influenced by opioid treatments and opioids themselves. Improved understanding of mechanisms that link sleep and opioid-related factors, such as changes in craving and/or ability to regulate emotions may highlight new opportunities for targeted treatment.

PI_NAMEs: CARSKADON, MARY A (contact);MCGEARY, JOHN E;RICH, JOSIAH D

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: actigraphy;addiction;Address;Affect;Architecture;Behavior;biological sex;Buprenorphine;Cessation of life;Characteristics;circadian;Circadian Dysregulation;Circadian Rhythms;Cognitive Therapy;cost;craving;Dose;Ecological momentary assessment;Electroencephalography;emotion regulation;Emotions;Financial cost;Human;improved;Individual;insight;Intervention;Link;Measures;medication for opioid use disorder;Melatonin;Methadone;Methods;Monitor;Motivation;negative affect;Neurocognitive;novel;Opioid;Opioid agonist;opioid agonist therapy;opioid epidemic;opioid use disorder;Outcome;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Phase;Phenotype;Polysomnography;poor sleep;Population;Protocols documentation;Qualitative Methods;Recovery;Relapse;relapse prediction;Reporting;Research;Risk Factors;Science;Site;Sleep;Sleep Architecture;sleep behavior;Sleep Disorders;Sleep disturbances;sleep pattern;sleep physiology;sleep quality;Sleeplessness;success;Symptoms;targeted treatment;therapy design;therapy development;treatment adherence;Treatment outcome;Work

PROJECT_TITLE: Investigating mechanisms underpinning outcomes in people on opioid agonist treatment for OUD: Disentangling sleep and circadian rhythm influences on craving and emotion regulation


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Gene Therapy;Genetics;Immunotherapy;Skin Cancer

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE Although some patients have durable disease control with current cancer immunotherapies, many fail to respond or progress after initially experiencing tumor regression. This proposal seeks to develop new, mechanism-based cellular immunotherapies to target melanoma and other common cancers with specific genetic alterations associated with resistance to current treatments. As part of these studies, new generalizable knowledge will be generated that improves our molecular understanding of how the adaptive immune system can distinguish between normal and transformed tissues.

PI_NAMEs: KLEBANOFF, CHRISTOPHER AUSTIN (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Acute Myelocytic Leukemia;Adaptive Immune System;Adoptive Cell Transfers;Adoptive Transfer;Affinity;Alleles;Antigen Presentation;Antigen Presentation Pathway;Antigens;beta-2 Microglobulin;Binding;Biochemical;Biometry;Blocking Antibodies;Blood;cancer cell;cancer immunotherapy;Cancer Patient;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;cell killing;Cell Physiology;Cell Therapy;Cellular immunotherapy;Clinical;Collection;Colorectal Cancer;Complex;CRISPR screen;cross immunity;cross reactivity;Cytolysis;Data;Defect;disorder control;engineered T cells;Epitopes;experience;FDA approved;Frequencies;gene therapy;Genes;Genetic;Genetic Determinism;Genetic Engineering;genome-wide;Genomics;Histocompatibility Antigens Class I;HLA Antigens;HLA-A gene;Immune;immune checkpoint;immune checkpoint blockade;immune function;immunogenic;immunogenicity;Immunotherapy;improved;in vivo evaluation;innovation;Knowledge;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Medical;Melanoma;men;MHC Class I Genes;Modeling;Molecular;multidisciplinary;Mutate;Mutation;neoantigens;neoplastic cell;novel;novel therapeutic intervention;Oncogenes;Oncology;Patients;Peptides;pharmacologic;Population;Pre-Clinical Model;preservation;Protein Isoforms;Recurrence;Resistance;response;Sampling;screening;selective expression;Skin Cancer;small molecule inhibitor;Solid;structural biology;Structure;Surface;T cell response;T-Cell Antigen Receptor Specificity;T-Cell Development;T-Cell Receptor;T-Cell Receptor Genes;T-Cell Receptor Therapy;T-Lymphocyte;Testing;Therapeutic;therapeutic target;therapy resistant;Time;Tissues;translational approach;Treatment Failure;tumor;Tumor Immunity;tumor immunology;Woman

PROJECT_TITLE: Novel cell therapy approaches for molecularly defined subsets of therapy-resistant melanoma

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WALTHAM

ORG_NAME: BRANDEIS UNIVERSITY

PHR: Project Narrative Disparities by race/ethnicity and disability status in food insecurity and healthcare outcomes are linked. The Supplemental Nutrition Assistance Program (SNAP) has been shown to reduce but not eliminate food insecurity, suggesting that enhanced levels of SNAP benefits may further reduce food insecurity and associated unfavorable healthcare outcomes, particularly among racial/ethnic minorities and people w ith disabilities, for whom these phenomena are disproportionately prevalent and impactful. While addressing concurrent pandemic and public policy-related changes (Aim 1), this project will exploit (i) both national Medicaid data and a novel set of linked claims, public health, and administrative SNAP data from Massachusetts and (ii) a staggered set of natural experiments created by the Families First Coronavirus Response Act (FFCRA) to examine the effects of SNAP benefits on healthcare outcomes (Aim 2) and disparities by race/ethnicity and disability status (Aim 3) in MA and the US.

PI_NAMEs: SONIK, RAJAN ANTHONY (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Address;Administrative Supplement;Affect;Age;Attention;care outcomes;Caring;Chronic;Clinical;cooking;Coronavirus;COVID-19;Data;Disabilities experience;disability;Disability status;Disabled Persons;Disease Management;disorder prevention;Disparity;disparity reduction;Dose;Economic Conditions;Economics;Emergency Care;Equity;ethnic minority;ethnic minority status;Ethnic Origin;Event;Excision;Expenditure;experience;Exposure to;Factor Analysis;Family;Food;food insecurity;Funding;Geography;Goals;Growth;Health;health care disparity;health data;health definition;health determinants;health difference;health disparity populations;Health Expenditures;Healthcare;Healthcare Systems;Heterogeneity;Hospitalization;Household;improved;improved outcome;Individual;Inequity;inpatient service;insight;Institute of Medicine (U.S.);Intervention;Lead;life span;Link;Machine Learning;Massachusetts;Measures;Medicaid;Medical;Methods;Modeling;Natural experiment;novel;nutrition;Outcome;outcome disparities;pandemic disease;Performance;Persons;Pharmaceutical Preparations;Policies;Preventive;programs;Public Health;Public Policy;Race;racial disparity;racial minority;Reduce health disparities;Resources;response;social;Social Welfare;stem;Techniques;Thinness;Time;trend;United States National Institutes of Health;Work

PROJECT_TITLE: Growth and decline in SNAP generosity: Outcome and equity implications

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cardiovascular;Clinical Research;Complementary and Integrative Health;Physical Injury - Accidents and Adverse Effects;Rehabilitation

ORG_CITY: AUSTIN

ORG_NAME: NANOHMICS, INC.

PHR: PI: Savoy Project Narrative Development of a conformable thermoelectric cooling/heating device would solve issues of traditional thermal and cold therapy by eliminating the need for dedicated refrigeration systems, coolers or chilled liquid circulators, gels, or ice. The inability to produce large-area flexible thermoelectric devices is a significant shortcoming that has kept these highly effective devices from being adapted into the form factor required for a low-profile solid-state cryotherapy device. Modern water/ice cooling methods can sometimes damage tissue by over-cooling and if continuously fed, require pumps, tanks and tubes that can be prone to leaks. The benefits in patient mobility, lower risk of deep vein thrombosis, and hands-free utility of a therapeutic regimen by conforming to a specific region of the body (i.e. “wearable”) and uniformly extract heat energy with power requirements commensurate with wearable batteries are numerous.

PI_NAMEs: SAVOY, STEVE MICHAEL (contact)

PROGRAM_OFFICER_NAME: WANG, XIBIN

PROJECT_TERMS: Address;Adoption;Affect;Ankle;Anti-Inflammatory Agents;Area;Arthroscopy;Articular Range of Motion;Bandage;Behavior;Biomedical Technology;Board Certification;Body Regions;Burn injury;Caring;Chills;Circulation;Climate Controls;cold temperature;Cold Therapy;Collaborations;compression therapy;Consumer Preferences;Consumption;cost;Data;Dedications;Deep Vein Thrombosis;Dependence;design;Development;Device Designs;Devices;Doctor of Medicine;Edema;empowerment;fabrication;flexibility;Freedom;Freezing;Gel;Hand;Heart Arrest;Heating;Hospitalization;Human Subject Research;Ice;improved;Inflammation;Injury;interfacial;Ions;Knee;knee replacement arthroplasty;Lifting;Limb structure;Liquid substance;Logic;Maintenance;manufacture;Manufacturer;Mattresses;Medical;Medical Device;Medicine;melting;Methods;Modeling;Modernization;novel;Operative Surgical Procedures;Orthopedics;Pain;pain score;patient mobility;Patient-Focused Outcomes;Patients;Performance;Phase;Physicians;Postoperative Period;postoperative recovery;power consumption;Power Sources;prevent;Production;professor;programs;prototype;Pump;Recovery;Refrigeration;Regimen;Research;Risk;risk mitigation;Site;Skin;skin burn;skin damage;soft tissue;Soft Tissue Injuries;solid state;Sports Medicine;Sprain;square foot;stem;support network;Surface;Surgeon;Swelling;System;Techniques;Technology;technology development;Temperature;Texas;Therapeutic;therapy adherence;Thrombosis;Time;Tissues;Trauma;Traumatic Brain Injury;Tube;Universities;Validation;Vasodilation;Water;wearable device;wireless communication;Wrist

PROJECT_TITLE: Ambulatory cryocooling therapy device