NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Placental disorders that affect the prenatal environment influence early neurodevelopment that underlies many neurodevelopmental disorders with major consequences throughout the life course. We will study neural mechanisms responsible for such cognitive disabilities towards developing diagnostic capabilities and exploring early dietary interventions aimed at reversal of these devastating conditions. These studies subsequently will have a major impact on infant outcomes and adult neurobehavioral functioning in society.

PI_NAMEs: DEVASKAR, SHERIN U (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: Adult;Adult Children;Affect;Alzheimer's Disease;Anxiety;Asphyxia Neonatorum;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavioral;Bioinformatics;Biological Process;Brain;Brain Hypoxia-Ischemia;Caloric Restriction;Cell Count;cell type;Cells;Central Nervous System;Cerebral cortex;Child;chromosome 22q deletion syndrome;Clinical;cognitive disability;Copy Number Polymorphism;Cortical Dysplasia;CRISPR/Cas technology;Dementia;Dependence;Detection;Developmental Delay Disorders;Diagnostic;diagnostic development;diagnostic value;dietary;Dietary Intervention;DNA Sequence Alteration;Early Intervention;early screening;Embryo;endophenotype;Environment;excitatory neuron;exome;Exposure to;extracellular;extracellular vesicles;Failure;fetal;Fetal Growth Retardation;Fetus;Gene Deletion;gene environment interaction;Gene Mutation;Genes;Genetic Transcription;genome sequencing;Germ Lines;Gliosis;Glucose;glucose transport;Glucose Transporter;Goals;Health;Heterozygote;Human;Huntington Disease;Hyperactivity;Hypoglycemia;Hypoxia;In Situ Hybridization;Incidence;induced pluripotent stem cell;Infant;infant outcome;Injury;insight;Intervention;intrauterine environment;Investigation;Ischemia;ketogenic diet;ketogentic;Ketones;Life Cycle Stages;Link;Malignant Neoplasms;Meningomyelocele;metabolomics;migration;Mus;Mutation;Nerve Degeneration;nerve stem cell;nestin protein;neural;neurobehavior;neurobehavioral;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;neuromechanism;Neurons;Non-Invasive Detection;novel;offspring;Organoids;overexpression;Phenotype;Placenta;Placenta Diseases;Plasma;postnatal;pre-clinical assessment;premature;prenatal;Process;prognostication;Protein Isoforms;Proteins;Reporting;Rodent;Seizures;Senile Plaques;single cell genomics;single-cell RNA sequencing;SLC2A1 gene;Societies;Synapses;Syndrome;Testing;transcriptome;transcriptome sequencing;transcriptomics;Translating;Vesicle;whole genome

PROJECT_TITLE: Prenatal Origins of Neurometabolic Consequences

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: FAYETTEVILLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE

ORG_STATE: AR

PHR: PROJECT NARRATIVE Tobacco access laws are intended to prevent youth and young adults from initiating and using all tobacco products; however, research about policy efficacy, enforcement challenges, and communication the tobacco industry has with the public about federal tobacco regulatory laws has only been explored through limited, traditional research methodologies. The training and proposed research in this career development award application will use publicly available social media (e.g., Twitter, Facebook) data to organically and systematically examine policy loopholes that circumvent policy efficacy, key challenges related to enforcement, and tobacco industry interference among emerging youth access laws (e.g., Tobacco 21, Flavor restriction policies, a maximum nicotine level law). This innovative research would provide the FDA with prompt, action- oriented recommendations about these policies which can enable the FDA to make meaningful responses to critical issues including policy loopholes, enforcement practices, and industry interference.

PI_NAMEs: DOBBS, PAGE D. (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Address;Adolescent;Age;Amendment;Area;career development;certificate program;Code;Communication;Complement;Computer software;Data;Educational workshop;Electronic cigarette;electronic cigarette use;Ensure;Epidemic;Exclusion;experience;Facebook;Future;gaps in access;Genus Mentha;Goals;Health;Hour;improved;Industry;innovation;Instagram;Investigation;K-Series Research Career Programs;Laws;Learning;Legal;Menthol;Mentors;Methodology;Methods;Nicotine;Outcomes Research;Pathway Analysis;Persons;Policies;Policy Analysis;Policy Maker;population based;prevent;Procedures;Process;public policy on tobacco;Publications;Recommendation;Regulation;Research;Research Methodology;response;Sales;social media;Social Network;Source;Statutes and Laws;Surveys;symposium;Taxes;Techniques;Technology;Time;timeline;Tobacco;tobacco advertising;tobacco control;Tobacco Industry;tobacco products;tobacco regulation;Tobacco use;Training;Twitter;young adult;Youth

PROJECT_TITLE: Loopholes, Enforcement Challenges, and Tobacco Industry Interference with Tobacco Control Policies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-K(90)S]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hearing Loss;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: HADLEY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

ORG_STATE: MA

PHR: Project Narrative Improving access to hearing health care for older adults is a public health priority. In order to better serve the growing population of older bilingual Latinx adults, we need to know what communication challenges and barriers to hearing care access they face in the community. This proposal aims to increase our knowledge base regarding the speech-in-noise understanding abilities and the communication needs and priorities of an underserved population of older bilingual adults.

PI_NAMEs: MAMO, SARA K. (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Adult;Affect;Age;age effect;age related changes;Aging;Applications Grants;Auditory;Auditory Perception;auditory processing;Auditory Threshold;bilingualism;Caring;clinical practice;Clinical Services;Cognitive;cognitive function;Communication;Communication Barriers;Communication difficulty;Communities;cost comparison;Data;Development;Ecological momentary assessment;English Language;Environment;executive function;experience;experimental study;Face;Focus Groups;Future;Goals;handheld mobile device;Health;Health Services Accessibility;Healthcare;Hearing;hearing impairment;hearing loss treatment;Hispanic;Improve Access;improved;Individual;Interview;Investigation;Knowledge;knowledge base;Language;language processing;Latino;Latinx;Latinx population;Life;Low income;Massachusetts;Measures;Methods;Noise;non-verbal;Observational Study;older adult;Older Population;Outcomes Research;Participant;people of color;Performance;physical conditioning;Population;Presbycusis;primary outcome;programs;Protocols documentation;public health priorities;Puerto Rican;Recording of previous events;Research;Research Project Grants;Sampling;service delivery;Service delivery model;Short-Term Memory;Signal Transduction;skills;social engagement;Social isolation;Societies;Spanish;Spanish/English;Speech;speech in noise;Speech Perception;Surveys;Testing;Time;Underserved Population;urban setting;virtual;Work

PROJECT_TITLE: Communication Challenges and Barriers to Hearing Care for Older Bilingual Latinx Adults

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: ES

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Obesity;Precision Medicine;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The global rise of many non-communicable diseases is driven in part by poorly understood interactions between an individual’s genetics and physical environment. The Turkana people of northwest Kenya provide a unique opportunity to identify Genotype-by-Environment interactions in the context of cardiometabolic disorders, as recent transitions from traditional, rural lifestyles to urban environments has driven an increase in metabolic disturbances often associated with a Western lifestyle. The goals of this project are to advance our understanding of how and why some individuals are more sensitive to environmental stressors than others, and to identify the molecular and genetic drivers of variation in immunometabolic homeostasis that modulate cardiometabolic risk.

PI_NAMEs: GARSKE, KRISTINA MARIE (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: Acute;Address;African American population;African ancestry;Biological Markers;Biological Process;Blood Glucose;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Chromatin;Chronic;Cities;Collaborations;Communities;Complex;Data;Detection;Development;Disease;disorder risk;Environment;environmental stressor;Exhibits;experience;Exposure to;Faculty;feeding;Fellowship;Gene Expression;gene network;Genes;Genetic;Genetic study;Genetic Transcription;genetic variant;Genetic Variation;Genome;Genomics;Genotype;global health;Goals;Health;health difference;high body mass index;Homeostasis;Human Genetics;improved;In Vitro;Individual;Individual Differences;Inflammatory;Inflammatory Response;Kenya;Knowledge;Lead;Life;Life Style;Marketing;Mentorship;Metabolic;Metabolic Diseases;Metabolic stress;migration;Modernization;Molecular;molecular phenotype;monocyte;Non-Insulin-Dependent Diabetes Mellitus;Nutritional status;Obesity;obesogenic;Pathway interactions;Pattern;Peripheral Blood Mononuclear Cell;Persons;phenotypic data;Physical environment;Population;precision medicine;Predisposition;pressure;Process;Prognosis;programs;Quantitative Genetics;Recording of previous events;Reporting;Research;Research Personnel;resilience;response;Risk;Role;Rural;rural-urban migration;Sampling;Shapes;Signal Transduction;skills;Societies;Sorting;Source;stem;Stimulus;Stress;System;Testing;Training;Training Support;trait;Transcript;transcriptome sequencing;United States National Institutes of Health;urban area;urban setting;Variant;Work

PROJECT_TITLE: Understanding the contribution of genotype-by-lifestyle interactions to cardiometabolic risk in individuals of east African ancestry

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-B(20)L]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Lung;Nutrition;Pain Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Sickle Cell Disease;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Sickle cell disease is an inherited red blood cell disorder that is characterized by high oxidative stress and inflammation. Human breast milk contains anti-oxidative and inflammation-fighting properties that align directly with the physiological challenges of sickle cell disease. The goal of this proposal is to examine the impact of breastfeeding among children with sickle cell disease. Given the historic low rates of breastfeeding among African American women, and our preliminary evidence demonstrating that breastfeeding is even lower among the sickle cell community, we will also conduct a small-scale trial to determine the acceptability of a community-based breastfeeding support group among mothers of children with sickle cell disease. The findings from this test-run trial will inform a future, definitive trial.

PI_NAMEs: PERNELL, BRANDI  (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: 2 year old;5 year old;Academy;Acceleration;acute care;acute chest syndrome;Address;Admission activity;Adolescent;Adult;Affect;African American;African American population;African American Women;African ancestry;Age;airway inflammation;Alabama;American;Anti-Inflammatory Agents;Antioxidants;Asthma;Behavior;Biological;Biological Markers;Blood Circulation;Blood specimen;Blood Vessels;Breast Feeding;breast pump;Breastfed infant;C-reactive protein;Cardiovascular Diseases;cell community;Certification;Cessation of life;Chest Pain;Child;Chocolate;Chronic;Chronic Disease;Clinical Trials Design;Communities;community engaged research;community organizations;comorbidity;Critical Care;design;Diagnosis;Diet;Disease;DNA;Drops;Dyspnea;Education;Erythrocytes;Ethnic Population;Event;Exclusive Breastfeeding;experience;Exposure to;Feasibility Studies;feasibility testing;Fever;fighting;Fostering;Future;Goals;Health;health organization;healthspan;Healthy People 2020;Hemoglobin;Hemolysis;High Prevalence;high risk population;Home visitation;Hospitalization;Human;Human Milk;Hypoxia;Immunologics;immunoregulation;improved;improved outcome;indexing;Individual;infancy;Infant;Infiltration;Inflammation;Inflammatory;inflammatory marker;inflammatory modulation;Inherited;Interleukin-8;Intervention;Intervention Trial;Knowledge;Lactation consultant;Lead;Leadership;Length;Life;life span;Life Style;lifestyle factors;Low income;lung health;Medial;Milk;Mothers;Neonatal Screening;Nitric Oxide;novel marker;Nutritional;Obesity;Observational Study;Organ;Outcome;Oxidative Stress;Pain;Pathogenesis;Pathologic Processes;Pathway interactions;Pediatrics;peer coaching;peer support;Persons;Physical activity;Physiological;Population;Prevalence;Prevention strategy;programs;Property;protective effect;Public Health;Publishing;racial population;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;Risk;role model;Running;Science;screening program;Services;Severity of illness;Sickle Cell;Sickle Cell Anemia;standard of care;Statistical Data Interpretation;Stress;Structure;Supplementation;Support Groups;support network;surveillance data;telomere;Testing;Thoracic Radiography;Training;trend;Vascular Endothelium;World Health Organization

PROJECT_TITLE: Promotion of Exclusive Breastfeeding in Children with Sickle Cell Disease for Improved Health Outcomes

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: BOSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Clostridioides difficile is the leading cause of healthcare-associated infections in the US and costs the health care system ~$5 billion to treat each year. Since the spore form of C. difficile mediates disease transmission and recurrence, understanding the molecular mechanisms by which C. difficile assembles its infectious spore form has the potential to lead to therapeutics that can prevent C. difficile disease recurrence and transmission.

PI_NAMEs: SHEN, AIMEE  (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Address;Anaerobic Bacteria;Antibiotics;Bacillus subtilis;Bacteria;Binding;Cell division;cell growth;Cell Wall;Cephamycins;Chimeric Proteins;Clostridium difficile;cost;Data;Dedications;Dependence;Disease;disease transmission;effective therapy;Enzymes;experience;Foundations;Frequencies;Genetic Transcription;glycosyltransferase;Growth;gut dysbiosis;Health Care Costs;Healthcare Systems;healthcare-associated infections;Homologous Gene;Human;Individual;Infection;inhibitor;insight;Location;Medial;Mediating;Membrane;Metabolic;Molecular;Morphology;Mus;Mutagenesis;Nosocomial Infections;novel;Patients;Penicillin-Binding Proteins;Peptidoglycan;Peptidyltransferase;Play;prevent;protein function;protein protein interaction;Proteins;Recurrence;Recurrent disease;recurrent infection;Reporter;Reproduction spores;Resistance;response;Role;standard of care;stressor;Testing;Therapeutic;Thick;transmission process;United States;Vancomycin;Work

PROJECT_TITLE: Spore Assembly in Clostridioides difficile

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The import of the viral capsid into the nucleus is an essential step in human immunodeficiency virus (HIV) infection of a host cell, yet little is known about this process at the molecular level. We will leverage innovative in vitro platforms and DNA nanotechnology to provide unprecedented molecular insight into the nuclear transport of HIV. We expect that this project will provide new mechanistic insight into HIV-1 nuclear entry and inspire innovations in antiretroviral therapy.

PI_NAMEs: LIN, CHENXIANG ;XIONG, YONG  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Affinity;antiretroviral therapy;Architecture;base;Binding;Biochemical;Biochemistry;Biological Assay;Biological Models;Capsid;Capsid Proteins;Cell Nucleus;Cells;Communities;Complement;Complex;Cryoelectron Microscopy;Cytoplasm;density;design;Diameter;Dimensions;Disease;DNA;Docking;Environment;experimental study;Face;Foundations;Gatekeeping;Genetic;genetic approach;Genome;Geometry;global health;Goals;HIV;HIV Infections;HIV-1;In Vitro;Individual;inhibitor;innovation;insight;Integration Host Factors;Invaded;Libraries;live cell imaging;Molecular;Mutagenesis;nanopore;Nanotechnology;novel;Nuclear;Nuclear Import;Nuclear Pore;Nuclear Pore Complex;Nuclear Pore Complex Proteins;Nuclear Proteins;nucleocytoplasmic transport;NUP214 gene;pathogen;Pattern;Pattern Recognition;Pore Proteins;Positioning Attribute;Process;protein structure;Proteins;Recombinants;Research;Research Personnel;Research Project Grants;Rest;Series;Specificity;structural biology;Structure;success;Surface;System;Techniques;Testing;therapeutic development;three dimensional structure;tool;Validation;Viral;Viral Genes;Virus;Virus Diseases;Virus Replication;Work;X-Ray Crystallography

PROJECT_TITLE: A multiscale approach for elucidating nuclear entry mechanisms of HIV-1 capsid

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Lung

ORG_CITY: DURHAM

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Patients with pulmonary fungal infections suffer both from the infection itself and lung tissue damages caused by overshooting antifungal immune responses. We recently discovered that alveolar macrophages (AMs) develop functionally distinct subpopulations upon fungal infections. Understanding the basic mechanism of how hosts keep an optimal balance of the immune responses is critical to developing new therapeutic approaches fungal infections.

PI_NAMEs: SHINOHARA, MARI L. (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Alveolar Macrophages;anti-fungal agents;Anti-Inflammatory Agents;Aspergillus fumigatus;ATAC-seq;beta-Glucans;Biological;Biological Process;cell type;Cell Wall;Cells;chemokine;Chemotactic Factors;Chromatin;Color;Cryptococcus;Cryptococcus neoformans;CXCL2 gene;dectin 1;Epigenetic Process;epigenetic regulation;Epithelial Cells;Equilibrium;Evaluation;Flow Cytometry;Gene Expression;Gene Expression Profiling;Generations;Genes;Genus Hippocampus;Growth;Heterogeneity;Hour;Immune;Immune response;Immunity;in vivo;Infection;Inflammation;Inflammatory;Inhalation;Lectin Receptors;Ligands;Lung;Macrophage;Maps;Mediating;Messenger RNA;Molecular;Mus;Mutant Strains Mice;Mycoses;neutrophil;new technology;novel;novel therapeutic intervention;pathogenic fungus;Patients;pharmacologic;Play;Population;Predisposition;Receptor Signaling;reconstitution;Reporter;Reporting;Resolution;response;Role;Sentinel;single-cell RNA sequencing;Specificity;Structure of parenchyma of lung;System;Technology;TLR2 gene;TLR4 gene;Transcriptional Regulation

PROJECT_TITLE: Heterogeneous immune responses of the alveolar macrophage population during pulmonary fungal infections

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Heart Disease;Hypertension;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE The postpartum period represents a unique time in a women’s life when many women gain excess weight and make the transition to becoming overweight or obese. We propose to rigorously study predictors of postpartum obesity and evaluate an innovative approach to improve weight loss in the postpartum period using an online behavioral weight loss program and social feedback from a team of other postpartum women. By identifying women at an early stage in life who will benefit the most from intensive lifestyle changes and testing interventions that are low cost, sustainable, and remotely delivered, we hope to significantly improve cardiovascular health and reduce the burden of cardiovascular disease in women, which is a central mission of the National Heart, Lung, and Blood Institute (NHLBI).

PI_NAMEs: LEWEY, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: 2 arm randomized control trial;Accountability;Adult;Affect;arm;Award;Behavior;behavior change;Behavior Therapy;Behavioral;behavioral clinical trial;behavioral economics;Body Weight decreased;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;career;career development;Censuses;Clinical;clinical predictors;Clinical Trials Design;cohort;cost;Data;Databases;design;Diabetes Mellitus;Diagnosis;Disease;Electronic Health Record;Elements;excessive weight gain;Face;Feedback;Future;gestational weight gain;Goals;Health behavior;health care service utilization;Health Sciences;healthy lifestyle;heart disease prevention;high risk;High Risk Woman;Hypertension;improved;Incentives;Incidence;Individual;Infrastructure;innovation;Institution;Intervention;intervention refinement;Knowledge;Life;Life Style;Link;Machine Learning;Maternal-fetal medicine;Medicine;Mentors;Mentorship;Methods;Mission;Modeling;Mothers;National Heart, Lung, and Blood Institute;Nature;neighborhood disadvantage;Neighborhoods;novel strategies;Obesity;obesity prevention;Outcome;Overweight;patient engagement;patient oriented;Patients;peer support;Pennsylvania;Perinatal;Persons;Physical activity;Physical environment;Population Heterogeneity;Population Sciences;Positioning Attribute;Postpartum Period;postpartum weight;Postpartum Women;Pre-Eclampsia;prediction algorithm;predictive modeling;predictive tools;Pregnancy;pregnancy disorder;pregnancy hypertension;prevent;programs;Qualitative Methods;racial diversity;randomized, clinical trials;recruit;remote delivery;remote intervention;remote technology;Research;Research Personnel;Rewards;Risk Factors;secondary outcome;Site;skills;social;Social Characteristics;Social Environment;Statistical Methods;Techniques;Testing;Time;Training;Universities;Vulnerable Populations;Weight;Weight Gain;weight loss intervention;weight loss program;Woman;Women's cohort;Women's Health;Women's mortality;women's prevention;Work

PROJECT_TITLE: Obesity Prevention in Postpartum Women at High-Risk of Cardiovascular Disease


ORG_CITY: VALHALLA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: NEW YORK MEDICAL COLLEGE

ORG_STATE: NY

PHR: Hypertension is an important risk factor for the development of heart disease, stroke, and kidney disease that affects greater than 40% of the population in the United States. Many hypertensive patients, especially African Americans, exhibit sensitivity to salt. Exaggerated stimulation of ion transporters in the kidney of these individuals increases the retention of salt, which heightens elevations in blood pressure associated with an increase in dietary salt intake. Our study will determine the mechanisms that regulate an intratubular TNF system that is activated in renal epithelial cells in response to increases in dietary salt intake and attenuates salt-dependent increases in blood pressure.

PI_NAMEs: FERRERI, NICHOLAS R (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: absorption;Address;Affect;African American population;Angiotensinogen;Attenuated;Binding;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure reduction;blood pressure regulation;Calcineurin;Calcineurin inhibitor;Cardiovascular Diseases;cardiovascular risk factor;Catalytic Domain;cell type;Chronic;Cyclosporine;cytokine;Data;Development;dietary salt;Distal;Electrolytes;Epithelial Cells;Excretory function;Exhibits;experimental study;Framingham Heart Study;Functional disorder;Genes;Genetic;Heart Diseases;Homeostasis;Human;Hypertension;hypertensive;Individual;Inflammatory;Ingestion;Intake;Ions;Kidney;kidney cell;Kidney Diseases;Lentivirus;Limb structure;Macula densa;Mediating;member;Messenger RNA;MicroRNAs;miRNA expression profiling;Molecular;mortality risk;mouse model;mRNA Transcript Degradation;Mus;Mutation;Nephrons;novel;Nucleotides;Patients;Phosphoric Monoester Hydrolases;Phosphorylation;Play;Population;posttranscriptional;PPP3CA gene;Production;Protein Isoforms;receptor;Regulation;renal epithelium;Renal function;Renal tubule structure;Renin-Angiotensin System;response;Risk Factors;Role;salt intake;saluretic;screening;Serine;side effect;Sodium Chloride;Source;Stroke;Structure of ascending limb of Henle's loop;symporter;System;Tacrolimus;Thick;Threonine;TNF gene;TNFRSF1A gene;Tubular formation;Tumor Necrosis Factor Activation;United States;Untranslated Regions;Untranslated RNA;Up-Regulation;Water

PROJECT_TITLE: Regulation of NKCC2 isoforms and blood pressure by tumor necrosis factor-alpha

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Disability Research;Infectious Diseases;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Infants with congenital cytomegalovirus are at greater risk of developmental delays and disabilities. Little is known about predictors of developmental delays or the experiences of mothers parenting these high risk infants. This project will examine the development of infants with congenital cytomegalovirus, and the experiences of their mothers, from birth to 12 months-of-age.

PI_NAMEs: PESCH, MEGAN H. (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Address;Affect;Age Months;Awareness;Behavioral;Birth;Cerebral Palsy;Characteristics;Child;Child Development;Child Health;Child Rearing;Childhood;Clinical;Cognitive;cohort;congenital cytomegalovirus;coping;Coping Skills;depressive symptoms;design;Development;Developmental Delay Disorders;Developmental Disabilities;Diagnosis;disability;Disease;Early Diagnosis;Early Intervention;Early treatment;Education;Emotional;empowerment;Ensure;experience;Failure;Family;Feeling;Future;Guilt;Health;Health Personnel;Hearing;high risk infant;high risk parents;improved;improved outcome;infancy;Infant;Infant Development;infant monitoring;infant outcome;innovation;instrument;Intellectual functioning disability;Intervention;Interview;Knowledge;Life;Link;long-term sequelae;Low income;maternal stress;maternal wellbeing;Measures;Mentors;Mission;Mothers;Nature;Newborn Infant;Outcome;Outcome Measure;Parents;Patient Self-Report;pediatrician;Personal Satisfaction;Persons;Pilot Projects;Productivity;progressive hearing loss;Psychosocial Influences;Randomized, Controlled Trials;Rare Diseases;Recommendation;recruit;Regrets;Rehabilitation therapy;Research;Research Methodology;Research Support;Research Training;resilience;Resources;response;Risk;screening program;Self Efficacy;Sensorineural Hearing Loss;Services;Severity of illness;Shame;Shapes;social;Stress;stressor;Support System;theories;Traction;Uncertainty;Vestibular dysfunction;virtual platform;Work

PROJECT_TITLE: Congenital cytomegalovirus: Infant developmental trajectories and parent experiences

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Burden of Illness;Clinical Research;Health Services;Osteoporosis;Patient Safety;Prevention;Women's Health Research

ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: There has been a substantial decline in the use of bisphosphonate (BP) therapies for osteoporosis which appears at least in part attributable to prescriber and patient concerns for rare, albeit potentially serious side effects, including atypical femoral fractures (AFF) and BP related osteonecrosis of the jaw (BRONJ). These concerns have led to recommendations for “drug holidays”; however, the safety of these holidays is uncertain, and reports of fractures during these holidays are increasing. We hypothesize that, using three large administrative databases (Kaiser Permanente (Northern California, Georgia and mid-Atlantic regions),HealthPartners and the Veterans Health Administration, including men and women and all races/ethnicities, that we can determine risks/benefits of long-term BP therapy, determine health benefits, healthcare cost and the cost effectiveness of drug holidays, and use this information to develop a web based risk factor calculator to guide shared decision making regarding long term use of these therapies.

PI_NAMEs: CARBONE, LAURA D (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Address;administrative database;Adult;alternative treatment;Area;Benefits and Risks;bisphosphonate;Bone necrosis;burden of illness;Calibration;California;Caring;Clinical;Clinical Trials;cohort;Communities;community living;comorbidity;cost;cost effective;cost effectiveness;Data;Decision Making;design;Discrimination;Drug usage;Dual-Energy X-Ray Absorptiometry;Educational workshop;Ensure;ethnic difference;Ethnic Origin;Excess Mortality;falls;Femoral Fractures;Fracture;fracture risk;Guidelines;Health;Health Benefit;Health Care Costs;Health care facility;Healthcare Systems;high risk;Holidays;human old age (65+);Individual;Internet;Intravenous;Jaw;Length;Long-Term Care;Measures;medication safety;men;Mid-Atlantic Region;Minnesota;Modeling;models and simulation;Morbidity - disease rate;mortality;multidisciplinary;Nursing Homes;older adult;older patient;Older Population;Online Systems;Oral;Osteoporosis;osteoporosis with pathological fracture;Outcome;Pathway interactions;patient population;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;point of care;Population;population based;Population Heterogeneity;Postmenopause;prediction algorithm;prevent;Prevention;Prevention therapy;Professional Organizations;Public Health;Quality of life;Race;racial difference;Recommendation;Recording of previous events;Reporting;Risk;Risk Estimate;Risk Factors;risk/benefit ratio;Safety;sex;Sex Differences;shared decision making;side effect;Site;Therapeutic;Time;tool;treatment duration;United States National Institutes of Health;Validation;Veterans Health Administration;Voice;Woman

PROJECT_TITLE: Calculator for Length of Use of Bisphosphonates (CLUB)


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Kacper B. Rogala | NIGMS R35 MIRA-ESI (PAR-20-117) | Project Narrative | October 3, 2022 Sensing of nutrient availability is one of most important tasks carried out by cells to ensure their survival in fluctuating environmental conditions. To this end, cells evolved a specialized signaling pathway called mTORC1 which reads the levels of cellular nutrients and accordingly adjusts the intensity of cellular metabolism. How the signals from nutrients — specifically amino acids leucine, arginine, and methionine — get delivered to mTORC1 is a major mystery, and this long-term project will address this question directly.

PI_NAMEs: ROGALA, KACPER  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Amino Acids;Amino Sugars;Arginine;Binding;cell growth;Cells;Complex;detection of nutrient;Disease;Ensure;Environment;Event;fascinate;Foundations;Future;Goals;Growth;Individual;Leucine;Malignant Neoplasms;Metabolism;Methionine;Molecular;Molecular Conformation;Monitor;mutant;National Institute of General Medical Sciences;novel;Nutrient;Nutrient availability;Pathway interactions;protein complex;Protein Kinase;Proteins;Protocols documentation;Research;Research Project Grants;response;Rest;Role;sensor;Signal Pathway;Signal Transduction;Signaling Molecule;Structure;Supplementation;therapeutic development;Thinking;Withdrawal

PROJECT_TITLE: Mechanisms of amino-acid sensing by the GATOR complex

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: NARRATIVE Patients with disproportional jaws have underbites or open bites and suffer from speech disorders twenty times more than the general public, whereby these patients seek jaw surgery and braces to treat issues heavily impacting their quality of life, including abnormal chewing, facial esthetics, and speech. However, it is unclear why these patients present with a high prevalence of articulation issues and whether surgically correcting their jaws will improve their speech problems; as such, we as providers cannot provide evidence-based treatment recommendations. To address this gap in knowledge, we will use state-of-the-art technologies to longitudinally track speech changes pre- and post-operatively to evaluate outcomes of treatment and generate evidence- based care recommendations.

PI_NAMEs: JACOX, LAURA ANNE (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Acoustics;Address;Alveolar;Alveolus;American;Anatomy;Anterior;Articulation;Arts;Award;Biology;Bite;Caring;Certification;Clinical;Communication;Complement;Consensus;Craniofacial Abnormalities;Data;Dental Schools;dentofacial;design;Development;Disease;Doctor of Philosophy;Enrollment;Ensure;Esthetics;Evaluation;evidence base;evidence based guidelines;Evidence based treatment;experimental study;Face;follow-up;Foundations;General Population;Generations;Gestures;graduate school;Grant;Growth;High Prevalence;Impairment;improved;Investigation;Jaw;Knowledge;Language;Link;Long-Term Effects;Longterm Follow-up;Malocclusion;Mastication;Medicine;Mentors;Movement;Open Bite;operation;Operative Surgical Procedures;Oral cavity;Oral Surgical Procedures;Orthodontic;Orthodontics;orthognathic;Participant;Pathologic;Pathologist;Pathology;Patients;Pattern;Population;Positioning Attribute;Postoperative Period;Posture;programs;Property;Provider;Publishing;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;Records;recruit;Research;Science;Scientist;Severities;skills;sound;Speech;Speech Disorders;Speech Pathology;Speech Sound;Speech Therapy;spelling;standard of care;Syndrome;Technology;Testing;Tongue;Tooth structure;Training;Training Activity;Treatment outcome;ultrasound

PROJECT_TITLE: Orthognathic speech pathology: Understanding how jaw disharmonies and their surgical correction influence speech

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Contraception/Reproduction;Infectious Diseases;Maternal Health;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Leveraging recent and novel findings from our human studies and mouse models, we propose an innovative approach to study sPTB. With a multidisciplinary team of scientists, we will utilize both in vitro and in vivo models to comprehensively analyze how cervicovaginal bacteria induce EMT and cervical remodeling. These studies will reveal key steps in the pathogenesis of sPTB. Findings from this proposal will provide insight as to new therapeutic targets to limit or prevent sPTB and in this manner, will fundamentally advance this field.

PI_NAMEs: ELOVITZ, MICHAL AVIVA (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Address;Automobile Driving;Bacteria;Biological Process;Biomechanics;Birth;Cancer Biology;Cervical;cervical remodeling;cervicovaginal;Cervix Uteri;clinically relevant;cohort;commensal bacteria;Epithelial Cells;Epithelium;Etiology;experimental study;Extracellular Matrix;fetal;Fetal Membranes;Fibrosis;Fostering;Gardnerella vaginalis;Gelatinase B;Germ-Free;Goals;Human;Immune response;In Vitro;in vivo;in vivo Model;Infection;Inflammation;Inflammation Mediators;innovation;insight;intraamniotic infection;Knowledge;Measures;Mesenchymal;Metabolic;metabolic profile;Microbe;microbial community;microbiota;Mobiluncus mulieris;mouse model;Mucous Membrane;multidisciplinary;Mus;new therapeutic target;novel;Pathogenesis;Peptide Hydrolases;Placenta;Pregnancy;pregnant;Pregnant Women;premature;Premature Birth;prevent;Preventive;Process;Production;Proteomics;Reporting;Reproducibility;reproductive tract;response;Role;Scientist;Series;Structure;Study models;successful intervention;Techniques;Term Birth;Testing;Therapeutic;therapeutic target;Time;Tissues;uterine contractility;Uterus;Vagina;vaginal infection;Work

PROJECT_TITLE: Deciphering the Role of Vaginal Microbes in Preterm birth


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Machine Learning and Artificial Intelligence;Radiation Oncology

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: NARRATIVE We propose to address the current challenges of effective and safe FLASH-RT clinical delivery by developing an image-pulse guidance system utilizing technological advances in radiation acoustic imaging and machine learning algorithms. Our approach is based on developing a general-purpose real-time radiation acoustic and ultrasound dual-modality imaging system with deep learning reconstruction and error detection algorithms for guiding and safeguarding electron and proton FLASH-RT deliveries. The feasibility and versatility of the dual image-guidance system will be evaluated using computer simulations, phantoms, and in vivo preclinical models towards clinical translation.

PI_NAMEs: BORTFELD, THOMAS R.;EL NAQA, ISSAM M. (contact);WANG, XUEDING

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: 3-Dimensional;3D ultrasound;absorption;acoustic imaging;Acoustics;Address;Algorithms;anatomic imaging;Anatomy;Animal Model;attenuation;Biomedical Engineering;Cancer Patient;cancer radiation therapy;Clinical;clinical implementation;clinical translation;Computer Simulation;cost effective;Data;Data Analytics;Data Science;Dedications;deep learning;deep learning algorithm;Deposition;design;Detection;detector;Development;Dose;Dose Rate;dosimetry;Electron Beam;Electrons;Emerging Technologies;Ensure;ex vivo imaging;experimental study;FarGo;Film;Geometry;Height;Image;image guided;imaging approach;imaging modality;imaging system;Imaging Techniques;improved;in silico;in vivo;in vivo imaging;in vivo Model;Institution;interoperability;Ionizing radiation;Ions;irradiation;Lesion;Machine Learning;machine learning algorithm;Malignant Neoplasms;Maps;Measures;Methods;Modality;Monitor;Monte Carlo Method;Morphology;multidisciplinary;Mus;Noise;Normal tissue morphology;Outcomes Research;Patient Care;Patients;Penetration;Performance;Physics;Physiologic pulse;Play;Positioning Attribute;pre-clinical;Pre-Clinical Model;preclinical study;proton beam;Protons;quality assurance;Quality of life;Radiation;Radiation Biophysics;Radiation Oncology;Radiation Physics;Radiation therapy;Radiology Specialty;Rattus;real time monitoring;Real-Time Systems;reconstruction;Resolution;Risk;risk minimization;Role;Safety;Signal Transduction;soft tissue;spatiotemporal;Structure;System;Techniques;Technology;temporal measurement;Testing;Therapeutic;Time;Tissues;tool;Translations;Treatment Efficacy;Treatment-related toxicity;tumor;Ultrasonography;ultrasound;Width;X-Ray Computed Tomography

PROJECT_TITLE: An Ionizing Radiation Acoustics Imaging (iRAI) Approach for guided Flash Radiotherapy

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Drug Abuse (NIDA only);Genetics;Mental Health;Natural Products;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Substance Misuse;Women's Health Research

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE  The objective of this project is to understand the impact of maternal marijuana use on epigenetic regulation and neurodevelopment in offspring spanning fetal life to early childhood, predisposing to addiction vulnerability later in life, in a non-human primate (NHP) model. The successful completion of our study will result in 1) new insights into the impact of maternal THC use on the developing fetal and infant brain, 2) the impact of THC- induced epigenetic alterations on trajectories of offspring neurodevelopment and behavioral regulation 3) the creation of a comprehensive, longitudinal in vivo map of offspring epigenetic regulation of neurodevelopment from fetal life to early childhood, and 4) characterization of ex vivo epigenetic and transcriptomic assessments that can be used as a reference for other drugs of abuse and environmental exposures.

PI_NAMEs: LO, JAMIE  (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: addiction;Address;Affect;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior;Behavioral;behavioral study;Binding;Brain;cannabinoid receptor;Cannabinoids;Chronic;Cognition;cognitive disability;Corpus striatum structure;Data;Development;Disease;Drug Addiction;drug of abuse;early childhood;Early Intervention;early screening;Environmental Exposure;Epigenetic Process;epigenetic regulation;fetal;Fetal Development;Fetal Growth;fetal marijuana exposure;fetus nutrition;Gene Expression Regulation;Goals;Health;High Prevalence;histone modification;illicit drug use;imaging capabilities;imaging study;in utero;in vivo;in vivo imaging;Infant;Inflammatory;innovation;insight;Lactation;Life;Link;Maps;Marijuana;marijuana use;maternal marijuana use;Mediating;Modeling;Modification;Molecular;Morbidity - disease rate;neurodevelopment;nonhuman primate;novel;offspring;Outcome;Placenta;Play;postnatal;Pregnancy;pregnant;prenatal;Psychotropic Drugs;Regulation;response;reward processing;Risk;Role;Secondary to;Signal Transduction;Tetrahydrocannabinol;THC exposure;Tissue Sample;Tissues;transcriptomics;translational impact;transmission process;trying to conceive;Woman

PROJECT_TITLE: Impact of maternal marijuana use on epigenetic regulation of offspring neurodevelopment


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: CHICAGO

ORG_DEPT: PATHOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: This project aims to understand how sticky molecules on the surface of skin cells facilitate the formation of a multilayered tissue to provide an essential physical and immune barrier covering the surface of the body. The study focuses on understanding new functions for these molecules, beyond their role in cell coherence, to control normal tissue development and disease processes.

PI_NAMEs: GREEN, KATHLEEN JANEE (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: 3-Dimensional;Actins;Adaptor Signaling Protein;Address;Adhesions;Apical;Architecture;Autoantibodies;Bacterial Toxins;Basal Cell;Biochemical;Biochemistry;Body Surface;Cadherins;Cell Adhesion Molecules;Cell membrane;Cell Nucleus;Cells;Complex;cytokine;Cytokine Signaling;Cytoplasm;Cytoskeleton;desmoglein 1;Desmosomes;Development;differentiation in vitro;Disease;Dynein ATPase;EGFR inhibition;Elements;Endosomes;Ensure;Epidermal Growth Factor Receptor;Epidermis;Epithelium;Equilibrium;Evolution;Failure;Genetic;genetic approach;Homeostasis;Human;human disease;imaging approach;Imaging Device;Immune;immunoregulation;In Vitro;in vivo;Infection;Inflammatory;Intercellular Adhesion Molecules;interleukin-23;Intermediate Filaments;keratinocyte;Knockout Mice;Life;Location;loss of function;Mechanics;Mediating;Mediator;Microtubules;Modeling;Molecular Chaperones;Morphogenesis;Motor;mouse model;Mus;mutant;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Normal tissue morphology;Nuclear;optical imaging;Pathway interactions;Patients;Phosphorylation Site;physical insult;polymerization;Polymers;Positioning Attribute;Process;programs;reconstitution;recruit;repaired;Role;Route;scaffold;severe dermatitis, multiple allergies and metabolic wasting syndrome;Signal Transduction;Simple Epithelium;Skin;skin disorder;skin regeneration;Sorting;spatiotemporal;Stratification;Stratified Epithelium;Surface;Syndrome;Targeted Toxins;Testing;Therapeutic;Tissues;trafficking;Vertebrates;Water

PROJECT_TITLE: Function of Desmoglein 1/Pemphigus Foliaceus Antigen

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: BROOKINGS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: SOUTH DAKOTA STATE UNIVERSITY

ORG_STATE: SD

PHR: 4/12/23 Project Narrative The South Dakota Animal Disease Research and Diagnos�c Laboratory (SD ADRDL) will serve as a Whole Genome Sequencing (WGS) core laboratory for the Veterinary Laboratory Inves�ga�on and Response Network (Vet-LIRN). Working with 5 partner source labs, SD ADRDL will perform WGS analysis on Salmonella enterica, Escherichia coli, Staphylococcus pseudintermedius, and other relevant organisms, uploading to NCBI bioprojects designated by Vet-LIRN Program Oﬃce. This data will be used to surveil for genes important to an�microbial resistance. 5U18FD006558 Page 1 of 1

PI_NAMEs: RUESCH, LAURA  (contact)

PROGRAM_OFFICER_NAME: CERIC, OLGICA

PROJECT_TITLE: ADRDL Diagnostic testing support for the FDA CVM VET-LIRN program


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: BATON ROUGE

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: Project narrative: Antimicrobial resistance in bacteria has become a significant concern in human health. The lack of antimicrobial stewardship and increased use of antimicrobial drugs in animal feeds has led to the emergence of antibiotic-resistant bacterial pathogens from companion and food-producing animals. The availability of benchtop DNA sequencing platforms provides an accurate whole- genome sequence (WGS) for a broad range of bacteria in less than a day. Thus, identifying genetic determinants of antimicrobial resistance and typing of clinically critical bacterial pathogens help accurately define the transmission of drug-resistant and multi-drug-resistant organisms. The work performed under this project will allow a continuing collaboration with Center for Veterinary Medicine’s Vet-LIRN into investigating of human and animal food safety using Whole Genome Sequencing (WGS).

PI_NAMEs: ROY, ALMA  (contact)

PROJECT_TITLE: Vet-LIRN Network Capacity-Building Project: Bacterial Whole Genome Sequencing


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: EUGENE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF OREGON

PHR: The proposed research focuses on carbonyl sulfide (COS) releasing molecules that function as caged hydrogen sulfide (H2S) donors due to the rapid conversion of COS to H2S by the ubiquitous enzyme carbonic anhydrase. This research is relevant to public health because the developed platforms enable new investigations into the beneficial roles of COS/H2S in different aspects of human health and disease. The new insights, chemical tools, and live animal outcomes will inform on the protective effects of COS/H2S donors in bone regeneration, making this research relevant to the NIH’s mission that pertains to developing and expanding fundamental knowledge to help reduce the burdens of human disability.

PI_NAMEs: PLUTH, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Address;Alginates;Animal Model;Animals;Attention;Biological;biological adaptation to stress;Biological Models;Biology;Blood Vessels;bone;Bone Regeneration;carbonate dehydratase;Cell Culture Techniques;Cell model;cellular targeting;Chemicals;Defect;design;disability;Disease;Engineering;Enzymes;experimental study;Family;Femur;Future;Gel;Goals;Health;Human;Hydrogen Sulfide;Hydrolysis;immune function;in vivo;in vivo Model;Individual;innovation;insight;Investigation;Knowledge;Locales;Longevity;Measures;Metabolism;Methodology;Methods;Mission;Modeling;novel strategies;Osteoclasts;Osteogenesis;osteogenic;Outcome;Play;protective effect;Protein Isoforms;Public Health;Rattus;recruit;regeneration model;Reproducibility;Research;Research Personnel;Role;Signaling Molecule;Stimulus;Sulfides;Sulfur;System;Technology;Therapeutic;thioester;tissue regeneration;Tissues;tool;United States National Institutes of Health;Up-Regulation;Work

PROJECT_TITLE: Hydrogen Sulfide and Carbonyl Sulfide Delivery for Biological Applications

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ORG_DEPT: GENETICS

PHR: Project Narrative: Meiosis is critical for gamete production and ensures faithful chromosome segregation in gametes. Our analysis of ZCWPW1 will provide important insights about the molecular events of chromosome pairing and etiology of male infertility in humans.

PI_NAMEs: COLE, FRANCESCA ;HAMMOUD, SAHER SUE (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Address;Affect;Aneuploidy;Binding;Biochemical;biophysical properties;Bypass;Cell Cycle;Characteristics;Chromosome abnormality;Chromosome Arm;chromosome missegregation;chromosome movement;Chromosome Pairing;Chromosome Segregation;Chromosomes;Compensation;Constitution;Cytology;Data;Defect;Diploidy;DNA Double Strand Break;DNA Repair;Double Strand Break Repair;Down's Syndrome;egg;Ensure;Etiology;Event;experimental study;Failure;Female;Frequencies;Functional disorder;Generations;Genetic;genetic approach;Genetic Crossing Over;genetic information;Genetic Recombination;Genome;Genomic Segment;Genomics;Genotype;Germ Cells;Germ Lines;Haploidy;high resolution imaging;Histone H3;histone methylation;Histones;Homologous Gene;Human;Hybrids;Immunoprecipitation;In Vitro;in vivo;Infertility;insight;Knowledge;Lead;Location;Lysine;male;Male Infertility;Mammals;Mass Spectrum Analysis;Mediating;Meiosis;Meiotic Prophase I;Meiotic Recombination;Mental disability;Methylation;Methyltransferase;Modeling;Modification;Molecular;Monitor;Mus;mutant;Nuclear Envelope;Nuclear Inner Membrane;Oocytes;Play;Ploidies;Process;Production;Prophase;Proteins;Reader;Role;sex;Site;Speed;sperm cell;Spermatocytes;SPO11 gene;Spontaneous abortion;System;telomere;Testing;Time

PROJECT_TITLE: The role of ZCWPW1 in meiosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-L(02)M]


NIH_SPENDING_CATS: Aging;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Neurosciences;Pain Research;Physical Activity;Prevention

ORG_CITY: OMAHA

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Narrative A hallmark feature of chronic heart failure (CHF) is decreased exercise tolerance and elevated sympathetic nerve activity at rest and during acute exercise, which limits the exercise capacity of these patients and contributes to the deterioration in cardiovascular function. The primary goal of the proposed research is to explore the contribution of macrophage infiltration in lumbar dorsal root ganglia in mediating the exaggerated exercise pressor reflex (EPR) as well as the mechanical afferent sensitization of the EPR in CHF. These data will be important in developing therapies for reducing cardiovascular dysfunction in CHF.

PI_NAMEs: WANG, HANJUN  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Acute;Acute Lung Injury;Address;Afferent Neurons;American;Animal Experiments;Animals;Anti-Inflammatory Agents;arm;Brain-Derived Neurotrophic Factor;Capsaicin;Cardiovascular Abnormalities;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;Cause of Death;Cells;Characteristics;Chronic;Clinical Research;Coculture Techniques;Congestive Heart Failure;Data;design;Deterioration;Disease;Exercise;exercise capacity;exercise intolerance;Exercise Tolerance;experimental study;Female;Femur;Fiber;Functional disorder;Ganglia;Glutamate Transporter;glutamatergic signaling;Glutamates;Goals;Heart failure;Heart Rate;Human;Hyperventilation;Immunofluorescence Immunologic;In Vitro;in vivo;Infiltration;Inflammatory;Intra-Arterial Injections;Ion Channel;Limb structure;Lipopolysaccharides;Macrophage;Macrophage Activation;male;Measures;Mechanics;Mediating;Metabolic;Modeling;Molecular;mouse model;Mus;Muscle;Myocardial Infarction;Nerve;neural;neuroinflammation;neuronal excitability;Neurons;neuroregulation;new therapeutic target;Nociceptors;patch clamp;Patch-Clamp Techniques;Pathologic;patient population;Patients;pharmacologic;Phenotype;Physical activity;Play;Potassium;pressure;Prostaglandin-Endoperoxide Synthase;protein expression;Quality of life;Rattus;receptor;Reflex action;Regulation;Reporter;Reporting;Research;respiratory;response;Rest;Role;Signal Pathway;Signal Transduction;Spinal Ganglia;Structure of stellate ganglion;Sympathetic Nervous System;Techniques;Testing;therapy development;Time;Tissues;TRPV1 gene;Vanilloid;ventilation;Vesicle;vesicular glutamate transporter 1;voltage;Western Blotting

PROJECT_TITLE: Neural Inflammation and Exercise Pressor Reflex in Heart Failure

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Liver Disease;Organ Transplantation;Social Determinants of Health;Substance Misuse;Transplantation

ORG_CITY: EAST LANSING

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Early liver transplantation (eLT), defined as LT evaluation with <6 months of alcohol abstinence, is associated with acceptable outcomes for patients with severe alcohol-associated liver disease (ALD) in retrospective studies. However, prospective, multi-center data including biopsychosocial factors on eLT for all patients with ALD in racially, culturally, and socioeconomically diverse populations are lacking. The INTEGRATE collaborative is a highly diverse investigative team that seeks to: 1) define factors influencing referral and waitlisting for eLT in ALD (selection); 2) identify which biopsychosocial factors are causally related and predictive of outcomes most important to stakeholders (outcomes); and 3) determine how integrated care among the healthcare team influences stakeholder-relevant outcomes in eLT for ALD (management).

PI_NAMEs: FERNANDEZ, ANNE CHRISTIE;MELLINGER, JESSICA LEIGH (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Abstinence;access disparities;Address;alcohol abstinence;Alcohol consumption;alcohol use disorder;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Behavioral Research;Biological Factors;biopsychosocial;biopsychosocial factor;candidate selection;career;Caregivers;Caring;Cirrhosis;Clinical;cohort;Communication;County Hospitals;Data;data harmonization;design;ethnic diversity;Ethnic Origin;Evaluation;Family;Focus Groups;Funding;Geographic Locations;health care disparity;health disparity;Hepatitis;improved;innovation;integrated care;Interview;Knowledge;Liver diseases;liver transplantation;Longitudinal cohort;Measures;Medical;Medical Care Team;Medical center;Medicine;member;Mental Health;Methodology;Methods;Michigan;Modeling;multidisciplinary;National Institute on Alcohol Abuse and Alcoholism;novel;organ allocation;Organ Donor;Organ Procurements;Outcome;outcome prediction;Pathway interactions;Patient Care;patient population;Patient-Focused Outcomes;Patients;Perception;Population;Population Heterogeneity;Positioning Attribute;preference;Process;prospective;Protocols documentation;Provider;Psychological Factors;Qualitative Evaluations;Race;racial diversity;Recurrence;Research;Research Methodology;Research Personnel;Resource Allocation;Resources;Retrospective Studies;Risk;risk prediction model;sex;social health determinants;socioeconomics;Sodium Chloride;stakeholder perspectives;Standardization;substance use;Surveys;survival prediction;Techniques;Texas;Time;transplant centers;transplant model;Transplantation;Underinsured;United States National Institutes of Health;Universities;virtual;Waiting Lists;Work

PROJECT_TITLE: 4/4: The INTEGRATE Study: Evaluating INTEGRATEd care to Improve Biopsychosocial Outcomes of Early Liver Transplant for Alcohol-Associated Liver Disease


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: NASHVILLE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: TENNESSEE STATE UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE: OVERALL The well-established Meharry Medical College/Vanderbilt-Ingram Cancer Center/Tennessee State University Cancer Partnership (MVTCP) triad provides an exceptional environment to identify and address health care inequities in cancer seen in underrepresented minorities. The proposed research projects, cores, and shared resource cores will grow research and propose evidence-based solutions address to these inequities. Further, the development of expanded research infrastructure at MMC and TSU, enhancement of minority education programs, and improvement to the effectiveness of cancer-related activities will address health care disparities in the greater Nashville geographical region, with the ultimate goal of contributing to reducing health disparities among cancer patients in minority and underserved communities.

PI_NAMEs: QUICK, QUINCY ANTOINE;WHALEN, MARGARET M (contact)

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: Address;anti-cancer research;Area;Award;Awareness;Basic Science;Behavioral;Big Data;Bioinformatics;Bioinformatics Shared Resource;Biological Factors;Biometry;Cancer Center;cancer clinical trial;cancer health disparity;cancer initiation;Cancer Patient;Cancer Research Project;career;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;collaborative approach;Colorectal Cancer;Communities;Community Health;community organizations;community research;Comprehensive Cancer Center;Death Rate;Development;Discipline;Disparity;Education;education research;Effectiveness;Environment;Equity;Ethnic Origin;Evaluation;evidence base;Extramural Activities;Faculty;Financial Hardship;Fostering;Geographic Locations;Geography;Goals;graduate student;Growth;health care disparity;Health Educators;high school;Immunooncology;improved;Incidence;Inequity;Infrastructure;Institution;Intervention Trial;Lead;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;medical schools;Medical Students;Minority;minority communities;Minority-Serving Institution;Mission;mortality;multidisciplinary;Oncology;Outcome;outcome disparities;outreach;outreach program;Pathology;Pathway interactions;Patient Participation;Peer Review;Population Research;Population Sciences;Prevalence;programs;Publications;Race;recruit;Reduce health disparities;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resource Sharing;screening;Series;socioeconomics;survivorship;Tennessee;Training;Translational Research;treatment trial;undergraduate student;Underrepresented Minority;underserved community;United States;Universities

PROJECT_TITLE: (3 of 3) MMC, VICC & TSU: Partners in Eliminating Cancer Disparities


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: WHALEN, MARGARET M (contact)

PROJECT_TERMS: Advisory Committees;Annual Reports;anti-cancer research;Basic Science;Belief;Cancer Center;cancer health disparity;career development;Clinical;Clinical Sciences;Collaborations;Communication;Community Outreach;Data;Disparity;Doctor of Philosophy;Educational workshop;Ensure;Ethnic Origin;Evaluation;Expenditure;experience;Faculty;faculty mentor;Faculty Recruitment;Fostering;Funding;Funding Agency;Funding Opportunities;Geography;Goals;Growth and Development function;Guidelines;Human Resources;implementation strategy;Infrastructure;innovation;Institution;Leadership;Malignant Neoplasms;medical schools;Mentorship;Mission;Monitor;National Cancer Institute;Occupational activity of managing finances;Office of Administrative Management;Phase;Population Sciences;Preparation;Principal Investigator;Process;Productivity;programs;Progress Reports;Race;recruit;Regulation;Reporting;Reproducibility;Research;Research Activity;Research Personnel;Research Project Grants;Resource Sharing;Resources;responsible research conduct;Services;Socioeconomic Status;Strategic vision;symposium;synergism;Tennessee;Training and Education;United States National Institutes of Health;Universities;Vision;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Disability Research;Fetal Alcohol Spectrum Disorders (FASD);Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Substance Misuse;Substance Misuse Prevention;Underage Drinking

ORG_CITY: AUSTIN

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: PUBLIC HEALTH RELEVANCE: Prenatal Alcohol Exposure (PAE), the leading cause of developmental disabilities, is difficult to prevent because adults, including pregnant women, with unmet mental health needs engage in risky patterns of alcohol consumption or have Alcohol Use Disorders (AUDs). The proposal seeks to understand the role of long non-coding RNAs in mediating alcohol effects on the developing brain (F99 phase) and in regulating alcohol-seeking behavior in adults (K00 phase), and will provide the applicant with training in drug repurposing and medications development for AUDs. This proposal is consistent with the goals of RFA-NS-19-011 to “support a defined pathway across career stages for outstanding graduate students from diverse backgrounds”, since it will facilitate my transition from studying FASD to studying AUDs, and with the NIAAA mission, as it will facilitate development of an independent academic career with a focus on AUDs.

PI_NAMEs: SALEM, NIHAL A (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: addiction;Adult;Alcohol consumption;alcohol effect;alcohol exposure;alcohol prevention;alcohol seeking behavior;alcohol use disorder;Alcoholism;Behavioral;behavioral phenotyping;Biology;Brain;career;Child;Code;Complement;deter alcohol use;Development;Developmental Disabilities;disability;drug repurposing;Ethanol;expectation;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Goals;graduate student;Heavy Drinking;in vivo;interest;Mediating;Mental Health;Mission;mouse model;National Institute on Alcohol Abuse and Alcoholism;nerve stem cell;novel;Pathway interactions;Pattern;Pharmaceutical Preparations;Phase;post-doctoral training;pre-doctoral;Pregnancy;Pregnant Women;Prevalence;prevent;Prevention Guidelines;programs;Pseudogenes;public health relevance;Regulation;Research;RNA;Role;Route;School-Age Population;screening;single-cell RNA sequencing;stem cells;Testing;Training;transcription factor;transcriptomics;Untranslated RNA

PROJECT_TITLE: From FASD to AUDs: Strategies for Preventing Alcohol Addictions


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Networking and Information Technology R&D (NITRD);Patient Safety;Physical Activity;Physical Rehabilitation;Rehabilitation;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: BIRMINGHAM

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

PHR: PROJECT NARRATIVE Twenty percent of patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease (COPD) are readmitted within 30 days of discharge. Pulmonary rehabilitation is associated with a reduction in hospitalization in patients with COPD, but significant barriers in availability and access limit its use. We propose a multicenter randomized controlled trial that will test whether a video telehealth pulmonary rehabilitation intervention that overcomes these barriers will reduce hospital readmissions, improve quality of life, and be cost-effective.

PI_NAMEs: ABAN, INMACULADA  (contact)

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: Activities of Daily Living;Acute;Adherence;Admission activity;Adverse event;Alabama;Anti-Inflammatory Agents;Area;biological adaptation to stress;Biometry;Bronchodilator Agents;Case Report Form;Certification;Chronic Obstructive Pulmonary Disease;Clinical Trials Data Monitoring Committees;Clinical Trials Design;Communities;comparative efficacy;Consent;copayment;cost effective;cost-effectiveness evaluation;Critical Care;Data;Data Analyses;data management;Data Management Resources;data quality;Data Set;design;Documentation;Dropout;Dyspnea;Economic Factors;electronic data;Electronic Mail;Eligibility Determination;Enrollment;Event;Exercise;exercise capacity;Exercise Tolerance;Fees;follow-up;Futility;Geographic Locations;Health Care Costs;Healthcare;Home;hospital readmission;Hospitalization;Hospitals;Hypersensitivity;improved;Information Dissemination;Insurance Coverage;Intervention;Link;Lung;Manuals;Manuscripts;Medical;Medicine;mid-career faculty;Monitor;Moods;Morbidity - disease rate;Multi-Institutional Clinical Trial;Multicenter Trials;Online Systems;Oxidative Stress;Patients;Pattern;Pharmaceutical Preparations;Phase;primary outcome;Principal Investigator;professor;programs;prospective;Protocol Compliance;Protocols documentation;psychologic;Public Health Schools;Publications;pulmonary rehabilitation;quality assurance;Quality of life;Randomized;Randomized, Controlled Trials;readmission rates;readmission risk;recruit;Rehabilitation Centers;Reporting;Research Design;Research Personnel;resilience;Resources;respiratory;respiratory morbidity;rural area;rural patients;Safety;safety assessment;Schedule;screening;secondary outcome;Self Efficacy;Service delivery model;Site;social;socioeconomics;standard of care;Statistical Data Interpretation;Support System;symptom treatment;Symptoms;System;telehealth;Testing;Time;Training;Transportation;treatment group;trial comparing;United States;United States National Institutes of Health;Universities;Update;uptake;urban area;urban underserved;Validation;web platform;Withdrawal;Writing

PROJECT_TITLE: 2/2 Video Telehealth Pulmonary Rehabilitation to Reduce Hospital Readmission in Chronic Obstructive Pulmonary Disease (Tele-COPD)

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(MA)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences;Regenerative Medicine;Transplantation

ORG_CITY: BALTIMORE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative There is no available treatment for vision loss in dry age-related macular degeneration, a leading cause of blindness in adults over 55 years of age. Vision loss occurs when retinal pigment epithelium (RPE) and cone photoreceptors degenerate, so transplanting them is a potential treatment to restore vision. Using a novel mouse cone and RPE transplantation model system to study cone–RPE interactions in a regenerative paradigm, we will characterize donor cone maturation over the long term, reveal age-related impact on regeneration efficacy, and identify cues in specific recipient cell types that promote functional vision repair.

PI_NAMEs: SINGH, MANDEEP  (contact)

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: Address;Adhesions;Adult;Affect;Age;age related;Age related macular degeneration;Age Years;aged;Animal Model;Biological Assay;Biological Models;Blindness;Cell Communication;Cell Survival;cell type;Cell-Cell Adhesion;Cells;Central Nervous System;Cone;Cues;dietary supplements;Differentiated Gene;Dryness;Electrophysiology (science);experimental study;eye transplantation;Gene Expression;Genes;Genetic Transcription;Goals;Histologic;Human;immunodeficiency;Immunosuppression;improved;In Situ Hybridization;in vivo;Integrins;Label;Length;Light;Macular degeneration;Measures;Mediating;Melanins;Mus;Natural regeneration;Neurites;Neuronal Plasticity;Nonexudative age-related macular degeneration;novel;Nutrient;old mice;Older Population;Opsin;Outcome;Phagocytosis;Phagosomes;Pharmaceutical Preparations;photoreceptor degeneration;Photoreceptors;Positioning Attribute;Process;Protocols documentation;regenerative;Regenerative capacity;repair function;repaired;Reporting;Research;response;Retina;retina transplantation;Retinal Cone;Retinal Degeneration;RNA;sex;sight restoration;single-cell RNA sequencing;Structure of retinal pigment epithelium;Synapses;System;Testing;Time;Transgenic Organisms;Translations;transplant model;Transplantation;transplantation therapy;Vision;Visual;visual cycle;Work

PROJECT_TITLE: Developing photoreceptor repair for macular degeneration therapy.


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Rural Health;Social Determinants of Health;Women's Health Research

PI_NAMEs: SELOVE, REBECCA  (contact)

PROJECT_TERMS: Address;Administrator;Adoption;Age;age group;Age Years;aged;BRCA1 Mutation;BRCA2 Mutation;Breast Cancer Detection;Breast Cancer Early Detection;Breast Cancer Risk Assessment Tool;Breast Cancer Risk Factor;cancer care;Cancer Center;cancer diagnosis;cancer health disparity;Cervical Cancer Screening;Clinic;Clinical;clinical care;clinical practice;community advisory board;community partners;Consolidated Framework for Implementation Research;Data;Data Collection;Death Rate;Diagnosis;Disease;Disparity;early screening;Education;Eligibility Determination;Equity;ethnic diversity;evidence base;Feedback;Funding;Future;Geography;Goals;Guidelines;Health;Health Services Accessibility;high risk;high risk population;High Risk Woman;implementation evaluation;implementation outcomes;implementation strategy;improved;improved outcome;Inferior;Infrastructure;Interview;Life;Location;Low Income Population;low socioeconomic status;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Measures;Medical Care Team;medical schools;member;Methods;Minority;mortality disparity;novel;Outcome;Patients;Phenotype;Population;Population Heterogeneity;Positioning Attribute;primary outcome;Proctor framework;programs;Provider;Public Health;Race;racial diversity;racial minority population;randomized, clinical trials;Recommendation;Research Design;Risk;Risk Assessment;risk stratification;rural area;rural dwellers;safety net;screening;screening program;secondary outcome;Site;socioeconomics;study population;supplemental screening;Surveys;Tennessee;Testing;The Vanderbilt-Ingram Cancer Center at the Vanderbilt University;Translating;Tumor Biology;Underserved Population;United States;Universities;uptake;Woman;Women Status;Work;young woman

PROJECT_TITLE: Project 1: BRAVE Strategy (Breast cancer risk assessment achieved)


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: BOSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: PROJECT NARRATIVE Degenerative tissue diseases that disproportionately affect female patients, such as sarcopenia and osteoporosis, are often caused by dysregulation of the delicate balance and regulation of extracellular matrix (ECM) structure. This research proposal will investigate how biological sex and hormonal signaling interacts with the process of ECM remodeling, from the initial sensing of local environmental cues through to final protein synthesis and incorporation, with the ultimate goal of developing novel tools to study sex-specific biology. These studies have broad implications for the treatment of degenerative disorders by enabling the identification and investigation of biomarkers that can be targeted to improve patient-specific therapeutics.

PI_NAMEs: CONNIZZO, BRIANNE KATHRYN (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Affect;Age;Biological Markers;biological sex;Biology;Bioreactors;Cardiac;Carpal Tunnel Syndrome;Cell Separation;Cells;Cellular biology;Cues;Custom;Degenerative Disorder;Degenerative polyarthritis;design;Development;Disease;Disproportionately impacts women;Engineering;Environment;Enzymes;Equilibrium;Estrogens;Exhibits;Extracellular Matrix;Female;Fibrosis;Goals;Gonadal Steroid Hormones;High Risk Woman;Homeostasis;hormonal signals;Hormones;improved;In Vitro;Individual;Injury;Investigation;Liquid substance;male;mechanical drive;mechanical stimulus;Mechanics;mechanotransduction;Mediating;Modeling;Musculoskeletal;novel;Osteoporosis;Patients;Phase;Play;Pregnancy;Process;Production;Progesterone;programs;Protein Biosynthesis;regenerative approach;Regulation;repaired;Research;Research Proposals;response;Role;sarcopenia;sex;Sex Differences;Signal Pathway;signal processing;Signal Transduction;Soft Tissue Injuries;Structure;Techniques;Therapeutic;Time;tissue regeneration;tissue repair;Tissues;tool;women patients

PROJECT_TITLE: Innate and Hormone-Mediated Sex Differences in Extracellular Matrix Remodeling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-L(55)R]


ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Project Narrative: Antimicrobial resistance (AMR) monitoring is a critical function for veterinary diagnostic laboratories to aid in identification of new or emerging resistance, to identify potential resistance reservoirs, and assess efficacy of interventions to reduce resistance development. Not only do resistant bacterial infections impact animal health and welfare, but they also have significant potential for causing negative human health consequences through transmission of resistant bacteria or resistance genes through food or animal contact. Whole genome sequence AMR data form important veterinary bacterial pathogens and improvements in standardized data quality assurance/quality control for bacterial resistance detection increases the ability of FDA Center for Veterinary Medicine to accurately detect resistance and provide more accurate monitoring of antimicrobial resistance in veterinary species.

PI_NAMEs: BURBICK, CLAIRE R (contact)

PROJECT_TITLE: Antimicrobial Resistance Monitoring of Bacterial Pathogens of Veterinary Concern


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prostate Cancer;Urologic Diseases

PI_NAMEs: WANG, XIAOFEI  (contact)

PROJECT_TERMS: 3-Dimensional;Ablation;Address;Affect;African American;AKT Signaling Pathway;American;androgen independent prostate cancer;Androgens;Attenuated;Biogenesis;biomarker identification;calcification;Cancer Etiology;cancer health disparity;cancer initiation;cancer prevention;caucasian American;cell growth;Cells;Cessation of life;Data;Death Rate;Disease;Disease Outcome;Doctor of Philosophy;Enterobacteria phage P1 Cre recombinase;exosome;experimental study;Female;Freezing;Generations;Genes;Gleason Grade for Prostate Cancer;Glycoproteins;Growth;Human;Immunohistochemistry;In Vitro;in vivo;Indolent;Invaded;Knock-out;Knockout Mice;Laboratories;Linear Regressions;LNCaP;male;Malignant neoplasm of prostate;Mediating;men;Messenger RNA;Mitogen-Activated Protein Kinases;Modeling;Molecular;Motility;mouse model;mRNA Expression;Mus;mutant;Mutant Strains Mice;nano-string;Neoplasm Metastasis;Null Lymphocytes;overexpression;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;PIK3CG gene;Play;probasin;Process;Production;Prognosis;Prognostic Marker;Prostate;prostate cancer cell;prostate cancer cell line;prostate cancer model;prostate cancer progression;Prostate Cancer therapy;Prostatic Neoplasms;Proteins;Proto-Oncogene Proteins c-akt;PTEN gene;Puberty;Refractory;Regression Analysis;Research Personnel;Role;Serum;Signal Pathway;Signal Transduction;The Vanderbilt-Ingram Cancer Center at the Vanderbilt University;Tissues;TLR4 gene;Transfection;transmission process;tumor;tumor growth;tumor initiation;tumor progression;Tumor Volume;tumorigenic;uptake;Western Blotting;Xenograft procedure;α-Fetoproteins

PROJECT_TITLE: Project 2: Fetuin-A in Prostate Cancer


ORG_CITY: SHEFFIELD

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: CERTARA UK LIMITED

ORG_ZIPCODE: S1 2BJ

PHR: Project Narrative This research aims to further enhance and verify performance of the Simcyp Multi-Phase Multi-Layer Mechanistic Dermal Absorption (MPML MechDermA) PBPK model, which has previously been leveraged for approval of a Diclofenac sodium topical gel (Tsakalozou et al. 2021). In vitro characterisation and permeation studies will be designed and conducted within the grant to isolate specific critical quality attributes and verify the model’s ability to differentiate between Q3 similar and Q3 different products. Ultimately, the development and verification of a reliable and robust dermal PBPK model enhanced with the specialized dermal formulation toolbox is expected to aid decision making and result in lower risk, more efficient and cost- effective development of generic drug products providing benefits to patients.

PI_NAMEs: CLARKE, JAMES  (contact)

PROGRAM_OFFICER_NAME: TSAKALOZOU, ELEFTHERI

PROJECT_TITLE: Formulation toolbox for topically applied drugs to account for physical parameters, dynamic metamorphosis and influence of excipients


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: SYRACUSE

ORG_DEPT: PHYSICS

ORG_NAME: SYRACUSE UNIVERSITY

PHR: Project Narrative To survive, all animals, from the simplest to most complex, must make decisions using multiple senses, but many affected by neurological and psychiatric disorders are unable to properly combine informationfrom multiple sensory organs. In humans, ethical and technical complications make it difficult to study the circuits that process multi-sensory information, so in this project, I will study how brains choose behavioral outcomes based on input from multiple senses in a simple yet representative model, the fruit fly larva. Despite having many fewer neurons, the larva’s insect brain shares many commonfeatures with higher organisms, so this research will allow us to better understand the defects that occur during disease, as well as advancing our understanding of the neural basis of normal multi-sensory processing.

PI_NAMEs: MIHOVILOVIC SKANATA, MIRNA  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Affect;Animals;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior;behavior prediction;Behavioral;Behavioral Assay;behavioral outcome;Brain;Central Nervous System;Cerebral hemisphere;Complex;conflict resolution;Decision Making;Defect;Disease;Drosophila genus;Dyslexia;Environment;Ethics;Genetic;Human;in vivo;information processing;Information Theory;Insecta;Language;Larva;Measures;Mental disorders;Microscope;Modeling;Motor Activity;Motor Neurons;Movement;multisensory;Nervous System;Nervous System Disorder;neural;neural circuit;neuromechanism;Neurons;Optics;optogenetics;Organ;Organism;phrases;Process;Reagent;reconstruction;Research;response;Role;Schizophrenia;Sensory;sensory input;sensory integration;Stimulus;Techniques;two-photon

PROJECT_TITLE: Neural mechanisms underlying behavioral variability in uni- and multi-sensory contexts

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(55)R]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

PI_NAMEs: MU, RICHARD  (contact)

PROJECT_TERMS: Abraxane;Academic Medical Centers;Affect;African American Women;Animals;anti-cancer;anti-cancer research;anti-PD-L1;anti-PD-L1 therapy;Antibody Therapy;Biocompatible Materials;Biological;bioluminescence imaging;C57BL/6 Mouse;Cancer Center;cancer health disparity;cancer immunotherapy;cancer therapy;Cardiotoxicity;Cells;checkpoint therapy;Clinical;clinical practice;Clinical Trials;controlled release;Death Rate;design;Disease;Doctor of Philosophy;Dose;Dose Limiting;Drug Kinetics;efficacy testing;experience;Extramural Activities;fabrication;Flow Cytometry;Formulation;Frequencies;Funding;Glycolates;Goals;Gynecologic Oncology;Human;human disease;human model;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune response;Immunity;Immunotherapeutic agent;Immunotherapy;immunotherapy clinical trials;improved;Incidence;Individual;innovation;intraperitoneal;Intraperitoneal Injections;Kinetics;Laboratories;Lesion;Ligands;Luciferases;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;medical schools;Methods;Minority;Modeling;Molecular;mortality;mouse model;Mus;Not Hispanic or Latino;novel;objective response rate;Outcome;Paclitaxel;particle;Patients;Peritoneal;Peritoneum;Pilot Projects;Polymers;Productivity;Research;Research Project Grants;Resected;response;response biomarker;Rodent;Rodent Model;side effect;single-cell RNA sequencing;success;System;Tennessee;Testing;The Vanderbilt-Ingram Cancer Center at the Vanderbilt University;Therapeutic Agents;Tissue Stains;Tissues;tool;Toxic effect;treatment adherence;Treatment Protocols;tumor;Tumor Burden;Tumor Immunity;tumor progression;United States National Institutes of Health;Universities;White Women;Work

PROJECT_TITLE: Project 1: Developing Immune Checkpoint Controlled Release Biomaterials for Caner Immunotherapy


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PROJECT_TERMS: Advanced Malignant Neoplasm;Advisory Committees;Cancer Center;cancer health disparity;Cancer health equity;Collaborations;Collection;Communication;Data;Data Analyses;Data Collection;data management;Data Reporting;Decision Making;design;Development;Education;Ensure;Evaluation;Feedback;Fostering;Funding;Goals;Grant;Health;health inequalities;improved;innovation;Institution;Investments;Leadership;Logic;Malignant Neoplasms;Measurable;Measures;medical schools;Methods;Modeling;Monitor;Nature;Outcome;Output;Performance;Practice Management;Principal Investigator;Process;Program Evaluation;programs;Publications;Quality of life;Recommendation;recruit;Research;Research Personnel;Resources;Respondent;Services;Students;success;Teacher Professional Development;Techniques;Tennessee;The Vanderbilt-Ingram Cancer Center at the Vanderbilt University;theories;Time;tool;Universities;Work

PROJECT_TITLE: Planning and Evaluation Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Precision Medicine;Prevention;Stroke

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: Project narrative Brain bleed due to a ruptured aneurysm (subarachnoid hemorrhage) leads to immediate and delayed brain injuries. This project will follow patients who are receiving a new treatment to reduce risk of delayed injury, namely nicardipine, which is administered directly into the cerebrospinal fluid. The study will study markers of treatment effect by using non-invasive blood flow monitor and study the pharmacology this drug for this indication.

PI_NAMEs: SADAN, OFER  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Adopted;Affinity;Aftercare;Bilateral;Biological Markers;biomarker development;Blood;Blood flow;blood pressure reduction;Blood Vessels;Brain;Brain Injuries;Calcium Channel Blockers;Cerebral Ischemia;Cerebrospinal Fluid;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Spasm;Cerebrovascular system;Cerebrum;cohort;constriction;Data;deoxyhemoglobin;Detection;Development;Diffuse;Dose;Drug Kinetics;Environment;Frequencies;frontal lobe;functional improvement;functional outcomes;Future;Half-Life;hemodynamics;Hemorrhage;high risk;hospital utilization;improved;improved outcome;Individual;individualized medicine;Injury;insight;intravenous administration;Ischemia;liquid chromatography mass spectrometry;Measures;Monitor;Nature;Near-Infrared Spectroscopy;Nicardipine;Nimodipine;Observational Study;Optics;Oral Administration;Outcome;Patient Selection;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacology Study;prevent;Prevention;prophylactic;prospective;Protocols documentation;Recommendation;response;Risk Reduction;Role;Rupture;Ruptured Aneurysm;Sampling;Smooth Muscle Myocytes;Spectrum Analysis;standard of care;Stroke;Subarachnoid Hemorrhage;Subarachnoid Space;targeted biomarker;targeted treatment;Testing;Therapeutic;Time;Titrations;treatment as usual;treatment effect;treatment optimization;Treatment outcome;treatment strategy;University Hospitals;Vasodilation;Vasospasm;Ventricular;Work

PROJECT_TITLE: Development of biomarkers to optimize intrathecal nicardipine treatment for cerebral vasospasm and delayed cerebral ischemia after subarachnoid hemorrhage

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Rare Diseases;Vaccine Related

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE Human arenaviruses cause devastating hemorrhagic fever disease that results in thousands of deaths every year, with the victims often members of the most vulnerable populations in the world. Effective vaccines and treatments are desperately needed, however, we must first gain a much deeper understanding of the molecular interactions between arenaviruses and the host immune system that result in protective immunity. Using a singular cohort of Lassa fever survivors in Eastern Sierra Leone, we will perform a detailed survey of the human antibody response to arenavirus infection to better understand viral mechanisms of immune evasion and to identify conserved sites of viral vulnerability which can be exploited by the immune system.

PI_NAMEs: ANDRABI, RAIEES AHMAD;BRINEY, BRYAN  (contact);SCHIEFFELIN, JOHN SCRIBNER;WARD, ANDREW BARRETT

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: adaptive immunity;Address;Africa;Antibodies;Antibody Response;Antibody titer measurement;Antigens;Area;Arenavirus;Arenavirus Infections;B-Lymphocytes;Basic Science;Binding;Biological Assay;Case Fatality Rates;Case Study;Categories;Cells;Cessation of life;Classification;Clinical;Clonal Expansion;cohort;Collaborations;Complex;Country;design;Development;Disease;Disease Outbreaks;Ebola;effective therapy;Electron Microscopy;Enzyme-Linked Immunosorbent Assay;Epitopes;Evaluation;Family;FDA approved;Foundations;Future;Genetic;genetic analysis;Geographic Distribution;Geography;Ghana;Glycoproteins;Goals;Government;Guinea;Heart;high risk;Hospitalization;Hospitals;Human;Humoral Immunities;Immune Evasion;Immune response;Immune system;Immunity;Immunogenetics;immunogenic;Immunoglobulin Class Switching;Immunoglobulin Somatic Hypermutation;Immunology;Infection;innovation;interest;Ivory Coast;Lassa Fever;Lassa virus;Liberia;long-term sequelae;Mali;Maps;member;Molecular;Monoclonal Antibodies;multidisciplinary;multiple omics;neutralizing antibody;Nigeria;novel;Old World Arenaviruses;pandemic potential;pathogen;Pathogenesis;pathogens of pandemic potential;Patients;Phenotype;Phylogenetic Analysis;Population;priority pathogen;Productivity;Property;Recording of previous events;Research Personnel;Resolution;response;Risk;RNA Viruses;Rodent;segregation;Serum;Sierra Leone;Site;Specificity;Structure;Surveys;Survivors;Tacaribe Complex Viruses;Techniques;Therapeutic;Togo;tool;translational study;transmission process;Vaccine Design;vaccine development;Vaccinee;Vaccines;Variant;Viral;Viral Hemorrhagic Fevers;Virus;virus host interaction;Vulnerable Populations;Work;Zoonoses

PROJECT_TITLE: Genetic, structural and functional profiling of the human antibody response to arenavirus infection


NIH_SPENDING_CATS: Aging

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Public Health Relevance. There is a lack of awareness in young, URM future scientists about biomedical science, aging related research and career options. This represents a threat to the future goal of creating a diversified workforce to eliminate health disparities in a rapidly aging population. Our proposed Research Education Program (REP) counters this threat in the early stages by providing early and frequent exposure to the biomedical sciences and ageing related career options through a focus on undergraduate experiences to prepare them for the graduate and healthcare workforce.

PI_NAMEs: NATHANIEL, THOMAS I (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: 3-Dimensional;Academic support;Achievement;Admission activity;Aging;aging population;aging related;aspirate;Awareness;Bachelor's Degree;Behavioral Research;Biomedical Research;biomedical scientist;career;Career Choice;career development;career networking;Clinical Research;Data;Development;Development Plans;Discipline;Education;education research;Educational Activities;Educational workshop;experience;Exposure to;Faculty;Future;Goals;graduate school;graduate school preparation;GRE Preparation;Health Disparities Research;health disparity;Healthcare;Individual;innovation;Institution;interest;Internships;Intervention;Journals;Leadership;lectures;Manuscripts;matriculation;Measures;meetings;Mentors;Mentorship;Minority Graduate Student;minority student;Mission;next generation;older adult;Oral;Participant;posters;Professional Organizations;Program Development;programs;public health relevance;Publications;recruit;Reporting;Research;Research Methodology;Research Personnel;Research Training;Role;Schools;Science;science, technology, engineering, mathematics, and medicine;Scientific Inquiry;Scientist;student participation;Students;summer program;summer research;symposium;synergism;Talents;Training;training opportunity;Training Programs;undergraduate student;Underrepresented Minority;underrepresented minority student;Vision;Visit;Writing

PROJECT_TITLE: Promoting diversity in research training and mentoring for underrepresented minority Students (URM).


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Social Determinants of Health

PROJECT_TERMS: African American;American;anti-cancer research;Biology;Cancer Biology;Cancer Center;cancer health disparity;career;Career Choice;career development;Chemistry;Clinical;Cognitive;Communities;Community Developments;Community of Practice;Development;Disparity;Doctor of Philosophy;doctoral student;education research;Educational workshop;Ensure;Environment;Evolution;experience;faculty mentor;Goals;graduate student;Growth and Development function;high school;High School Student;innovation;Institution;interest;Laboratory Research;Latinx;learning materials;Maintenance;Malignant Neoplasms;Master of Public Health;medical schools;Medical Students;Mentors;Pathway interactions;peer coaching;Population;Population Heterogeneity;Population Sciences;programs;Psychosocial Assessment and Care;psychosocial resources;recruit;Research;Research Personnel;Research Project Grants;Research Support;Resources;Schools;Science;Self Efficacy;Series;social;student participation;Students;success;Talents;Tennessee;The Vanderbilt-Ingram Cancer Center at the Vanderbilt University;theories;translational cancer research;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Students;Universities

PROJECT_TITLE: Research Education Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Diabetes;Immunotherapy;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: Cell transplantation is a promising treatment option to replace nonfunctioning hormone secreting organs like endocrine pancreas. We propose a prevascularized encapsulation platform with local sustained immunosuppression to protect transplanted islet from immune rejection, avoiding adverse effects of systemic immunosuppression regimens, while providing an environment conducive for successful engraftment. This system has potential for a breakthrough in islet transplantation to significantly improve care and quality of life of patients with type 1 diabetes.

PI_NAMEs: GRATTONI, ALESSANDRO  (contact);NICHOLS, JOAN ELIZABETH

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Address;Adoption;Adverse effects;Affect;Allogenic;allotransplant;Anoxia;Beta Cell;Biodistribution;Biometry;Blood Vessels;Caring;Cell Physiology;Cell Survival;Cell Therapy;Cell Transplantation;Cells;Clinical;clinical development;clinical investigation;Clinical Research;clinical translation;Collaborations;conditioning;Cutaneous;Data;design;Diabetes Mellitus;diabetic;diabetic rat;Disease;Drug Delivery Systems;Drug Implants;Drug Kinetics;efficacy evaluation;Encapsulated;engineered stem cells;Engraftment;Environment;euglycemia;Event;Exposure to;flexibility;Future;Goals;Graft Rejection;Homing;Hormone secretion;Hydrogels;Hypoxia;Immune;immunoregulation;immunosuppressed;Immunosuppression;Immunosuppressive Agents;Implant;improved;In Situ;innovation;Insulin-Dependent Diabetes Mellitus;islet;islet allograft;Islets of Langerhans;Islets of Langerhans Transplantation;Life;life span;Longitudinal Studies;manufacture;Membrane;Mesenchymal Stem Cells;Microspheres;minimally invasive;Modeling;Nanoporous;neovascularization;Nutrient;Organ;Organ Transplantation;Osmosis;Oxygen;Patients;Pharmaceutical Preparations;pharmacokinetic model;Pharmacologic Substance;Physiological;Polymers;Positioning Attribute;post-transplant;prototype;Publishing;Pump;Quality of life;Regimen;Research;Rest;Safety;scaffold;Site;stem cells;subcutaneous;Supporting Cell;System;Technology;technology platform;Testing;Therapeutic;Thinness;Tissue Engineering;Toxic effect;Translating;Transplantation;Transplantation Immunology;tumor-immune system interactions;Vascularization;Work

PROJECT_TITLE: Vascularized Islet transplantation NICHE with local immunosuppression for the treatment of type 1 diabetes

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]