NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Wound Healing and Care

ORG_CITY: CHICAGO

ORG_DEPT: DERMATOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Cell entry of SARS-CoV-2 depends on binding of the viral spike (S) protein to the host cell receptor ACE2 and its priming by host protease TMPRSS2. The findings that skin biopsies were SARS-CoV-2 RNA positive; skin cells express both ACE2 and TMPRSS2 whose expression is increased in inflamed/wounded skin; and that there are skin manifestations of COVID-19, suggest that skin could be potentially an additional port of entry for SARS-CoV-2. We will test this hypothesis using pseudotyped Spike (S) protein-containing lentiviruses, 2D- and 3D-cultures made from African American, Hispanic and White non-Hispanic human epidermal keratinocytes pretreated with cytokine cocktails to induce ACE2 and TMPRSS2.

PI_NAMEs: BUDUNOVA, IRINA  (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;3-Dimensional;ACE2;Acute;Address;African American;African American population;airway epithelium;Atopic Dermatitis;Binding;Biological Factors;Biology;Capsid Proteins;Cells;Chickenpox;Chronic;Communities;Coronavirus;COVID-19;COVID-19 burden;COVID-19 cytokine storm;COVID-19 impact;COVID-19 pathogenesis;COVID-19 patient;COVID-19 risk;COVID-19 vaccine;cytokine;cytokine release syndrome;Data;Death Rate;Dermatologic;Development;Disparity;Epidermis;Epithelial Cells;Ethnic Origin;Ethnic Population;experimental study;Eye;Future;Gene Expression;Genes;Glycoproteins;Heart;Herpes Simplex Infections;Herpes zoster disease;Hispanic;hospitalization rates;Human;IL17 gene;IL4 gene;Immune Evasion;In Vitro;in vitro Model;Individual;Infection;infection rate;Infectious Skin Diseases;Inflammation;Inflammatory;Inflammatory Response;innovation;Interferon Type II;Interleukin-1 beta;Interleukin-13;interleukin-22;Interleukin-6;keratinocyte;Kidney;Knowledge;Latino;Lentivirus;Messenger RNA;Modeling;Molecular;Molluscum contagiosum virus;Morphology;Multiple Organ Failure;mutant;Mutate;Mutation;Nose;Not Hispanic or Latino;novel;Organ;Pancreas;Pathogenesis;Patients;Peptide Hydrolases;Population;Prevention;programs;Property;Proteins;Psoriasis;Race;racial population;receptor binding;Receptor Cell;Recovery;Reporter;Reporting;response;RNA;Role;Route;Sampling;SARS-CoV-2 infection;SARS-CoV-2 variant;Signal Transduction;Skin;skin biopsy;skin disorder;Skin Manifestations;skin wound;Socioeconomic Factors;Surface;Symptoms;Testing;three dimensional cell culture;Tissues;TMPRSS2 gene;TNF gene;Tomatoes;transcriptome sequencing;transmission process;vaccine access;vaccine hesitancy;Variant;Viral;viral RNA;Viremia;Virus;Work;wound;wound healing

PROJECT_TITLE: Potential role of skin in SARS-CoV-2 infection


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE Socioceconomically disadvantaged individuals typically have poor outcomes in behavioral weight loss interventions, but the reasons for this are unknown. This project will characterize the mechanisms through which adverse daily experiences and present bias -- a cognitive adaptation to harsh and unpredictable environments -- account for disparities in weight loss outcomes.

PI_NAMEs: APPELHANS, BRADLEY M. (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Accelerometer;adaptive intervention;Address;Adherence;Adult;adult obesity;Adverse event;Attention;Behavior Control;Behavior Therapy;Behavioral;Body Weight decreased;Cardiovascular Diseases;Clinical;Cognitive;cognitive neuroscience;cohort;comorbidity;design;Development;dietary;Dietary intake;Disparity;Disparity population;Eating Behavior;Ecological momentary assessment;Education;Enrollment;Environment;Ethnic Origin;Event;executive function;experience;Exposure to;follow-up;Food;Future;Goals;Income;increased appetite;Individual;Individual Differences;individualized medicine;Intervention;Investments;Link;low socioeconomic status;Measures;Mediating;Mediator;Modeling;Monitor;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutic intervention;Obesity;obesity risk;obesity treatment;Outcome;Pattern;Phenotype;Physical activity;Population;Poverty;Psychology;Race;racial disparity;racial minority status;racial population;Risk;Role;Sampling;socioeconomic disadvantage;socioeconomic disparity;Socioeconomic Status;standard of care;Stress;Testing;theories;Time;Treatment outcome;Unhealthy Diet;Weight;weight loss intervention;Weight maintenance regimen

PROJECT_TITLE: Stress, race, and cognitive mediators of SES-related disparities in behavioral obesity treatment outcomes

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Narrative The goal of this project is to combine mathematical modeling with quantitative experimental approaches to understand the feedback and feed forward loops that regulate intracellular signaling networks. In human cells, dysregulation of these networks leads to many diseases, including cancer and heart disease. The ultimate goal of this project is the development of predictive models of in vivo cellular processes that can be used in the rational design of therapeutic strategies for treating disease.

PI_NAMEs: ELSTON, TIMOTHY C (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Actins;Address;Bacteria;Biology;Cancer Biology;Cell model;Cell Physiology;Cell surface;Cells;Collaborations;Cues;Cytoskeleton;Development;Disease;Environment;Epithelium;Etiology;experimental study;Feedback;fungus;Goals;Growth;Heart Diseases;Hormones;Human;human disease;Image Analysis;in vivo Model;Ingestion;insight;Investigation;Malignant Neoplasms;mathematical model;migration;Nutrient;Partner in relationship;Pattern;Phagocytosis;Pharmacology;predictive modeling;Process;Property;pullulan;rational design;receptor;Regulatory Element;response;Saccharomyces cerevisiae;Shapes;Signal Pathway;Signal Transduction;Site;spatiotemporal;Stimulus;Stress;System;Therapeutic;Time;transmission process;Yeasts

PROJECT_TITLE: Mathematical modeling of cellular signaling systems

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Genetics;Human Genome;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

ORG_STATE: MI

PHR: PROJECT NARRATIVE This is an extension to the parent ESI MERIT R37CA230748. We propose an additional Aim of characterizing non-genetic contributors to individual cancer cell states in primary human ovarian cancer tumors, using novel single-cell technologies that achieve near-bulk coverage in single cells. This completes and expands the bulk and microdissected approaches in the parent grant.

PI_NAMEs: SHEN, HUI  (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Address;Area;ARID1A gene;base;Base Pairing;Behavior;Binding Sites;Bioinformatics;bioinformatics tool;Biological Assay;bisulfite;BRCA1 gene;cancer cell;Cancer Patient;cancer subtypes;cell type;Cells;chemotherapy;Chromatin;Clear Cell;Clinical;Clinical Management;Codependence;cost effective;COVID-19;Data;Development;Diagnosis;Disease;DNA;DNA Methylation;DNA Sequence Alteration;Endometrial;endometriosis;Endometrium;Enhancers;Enzymes;Epigenetic Process;epigenome;epigenomics;Epithelial ovarian cancer;Freezing;Genetic Transcription;genome-wide;Heterogeneity;Human;Hybrids;Individual;interest;KRAS2 gene;Lasers;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Maps;Menstrual cycle;Methylation;Molecular;Mutation;Neoplasm Metastasis;neoplastic cell;new technology;non-genetic;novel;nucleosome occupancy and methylome sequencing;Oncogenic;Ovarian Clear Cell Tumor;Ovarian Endometrioid Adenocarcinoma;Ovarian Serous Tumor;Paper;parent grant;Parents;Phase;Phenotype;PIK3CA gene;Platinum;Process;Prognosis;promoter;Publishing;Regulatory Element;Research;Research Priority;Resistance development;Resolution;Role;Sampling;Serous;Signal Transduction;single cell technology;Specimen;Standardization;Technology;The Cancer Genome Atlas;TP53 gene;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;transcriptomics;tumor;United States;Variant

PROJECT_TITLE: High-throughput Epigenomic Mapping of Regulatory Elements in Ovarian Cancer at Basepair Resolution


ADMINISTERING_IC: HD

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Disability Research;Intellectual and Developmental Disabilities (IDD);Mental Health

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Our postdoctoral T32 program aims to provide the next generation of investigators with state-of-the art training in intellectual disability research. It is designed across traditional scientific disciplines to provide trainees with broad-based technical and conceptual approaches to apply to the study of pediatric brain disorders and related conditions. We also aim to engender sensitivity in our trainees for individuals with IDD and for their families. Our ultimate objective is to train individuals so they have the concepts, experiences, and skills required to initiate and sustain successful long-term independent careers dedicated to decreasing the burden of intellectual disability in our society.

PI_NAMEs: MOLHOLM, SOPHIE ;WALKLEY, STEVEN UPSHAW (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: Disability research;Intellectual functioning disability;Training

PROJECT_TITLE: Training in Intellectual and Developmental Disabilities (IDD) Research


ADMINISTERING_IC: MD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: ATLANTA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: MOREHOUSE SCHOOL OF MEDICINE

ORG_STATE: GA

PHR: PROJECT NARRATIVE The proposed FIRST Coordination and Evaluation Center will serve as a national resource assess the impact of key institutional culture change strategies and other innovative approaches implemented at FIRST Cohort sites to promote inclusive excellence.

PI_NAMEs: OFILI, ELIZABETH O. (contact);RIVERS, BRIAN M.

PROGRAM_OFFICER_NAME: ROUSSOS, GINA PATIENCE

PROJECT_TERMS: Address;Agreement;Algorithms;Attention;Award;cohort;Collaborations;Collection;Common Data Element;Communication;Communities;Data;Data Analyses;Data Analytics;data cleaning;Data Collection;data harmonization;data management;data privacy;data sharing;Data Storage and Retrieval;diversity and inclusion;Education;Equity;Ethnic Population;Evaluation;Evidence based practice;Extramural Activities;Faculty;Faculty Recruitment;Funding;Goals;health equity;innovation;Institution;Logic;Measurement;Measures;meetings;Mentors;Modeling;Morehouse School of Medicine;novel;Outcome;Persons;Process;Productivity;Program Evaluation;programs;Publications;Quality Control;racial population;recruit;Reporting;Research;Research Peer Review;Research Personnel;Resources;Science;Scientific Advances and Accomplishments;Scientist;Site;success;theories;tool;United States;United States National Institutes of Health;Validation;Woman

PROJECT_TITLE: FIRST Coordination and Evaluation Center  to promote inclusive excellence


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative Multiple lines of evidence suggest that deficiency of Dicer contributes to the pathogenesis of aberrant choroidal neovascularization, a prevalent and blinding complications that arises in age- related macular degeneration and other conditions. We will investigate major Dicer substrate classes, develop novel experimental agents that bypass Dicer processing, and study the role of Dicer in aging with the overall goal that understanding this pathway in retinal disease could provide new medically relevant knowledge for this blinding condition.

PI_NAMEs: GELFAND, BRADLEY DAVID (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Address;Affect;Age;age related;Age related macular degeneration;aged;Aging;animal old age;Basic Science;bevacizumab;Biogenesis;Biological;Blindness;Blood Vessels;Bypass;Choroid;Choroidal Neovascularization;design;Development;Diabetic Retinopathy;DICER1 gene;Drug Targeting;Effectiveness;Elements;Enzymes;Exhibits;Exudative age-related macular degeneration;Eye;Feasibility Studies;Gene Silencing;Gene Transfer;Genes;Genetic Transcription;Goals;Growth;Human;Immune;Impairment;improved;Individual;innovation;insight;Institution;Intervention;Knowledge;Lesion;Mediator;Medical;MicroRNAs;Modeling;Molecular;Mus;neovascular;neovascularization;next generation;novel;novel therapeutics;Nuclear;ocular angiogenesis;ocular neovascularization;Outcome;Pancreatic ribonuclease;Pathogenesis;Pathologic;Pathologic Neovascularization;Pathology;Pathway interactions;Phenocopy;postnatal;Predisposition;prevent;Process;Proteins;Publishing;Regulation;Retina;Retinal Diseases;Retinal Neovascularization;Retinopathy of Prematurity;Ribonuclease III;Risk Factors;RNA;RNA Interference;RNA Processing;Role;Severities;small hairpin RNA;targeted treatment;Testing;therapeutic target;tissue degeneration;tool;Translational Research;Tumor Angiogenesis;United States;Variant;Vascular Diseases;vector;VEGFA gene;Vision

PROJECT_TITLE: DICER1 deficiency in aberrant chorioretinal neovascularization

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Childhood Injury;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Mental Health;Pediatric;Rural Health;Social Determinants of Health;Suicide

ORG_CITY: BOONE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: APPALACHIAN STATE UNIVERSITY

PHR: Project Narrative Suicide is the second leading cause of death among youth in the US. The proposed research is relevant to public health because it will integrate real-time data on suicide risk among youth with national data on social determinants of health and COVID-19 burden to determine how suicide risk among youth have changed throughout the pandemic, how these changes vary by different sociodemographic groups, and how social determinants of health and COVID-19 impact suicide risk. This research is particularly needed in light of the pandemic’s impact on youth mental health and recent advisories from the US Surgeon General that highlight the need for a better understanding of the impact of the pandemic on youth.

PI_NAMEs: THOMPSON, MARTIE P (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: Accident and Emergency department;Address;Age;Appalachian Region;Award;Cause of Death;Communities;COVID-19;COVID-19 burden;COVID-19 impact;COVID-19 pandemic;Data;Data Analyses;Data Analytics;Data Set;Data Sources;Databases;demographics;digital mental health;Economics;Education;Environment;experience;Gender;graduate student;Grant;Growth;Health;health disparity;Healthcare;Human Resources;Individual;Infrastructure;innovation;Institution;Investigation;Lead;Light;Link;Location;Mediating;Mental Health;Modeling;multilevel analysis;novel;pandemic disease;pandemic impact;Persons;Principal Component Analysis;Public Health;Publications;Race;racial identity;Reporting;Research;Research Personnel;Research Training;response;Risk Factors;Role;Rural;Rural Appalachia;Science;Sex Orientation;sexual identity;social;social health determinants;sociodemographic group;student mentoring;Students;suicidal behavior;suicidal risk;Suicide;suicide rate;Surgeon;System;Testing;Text;Time;Training;traumatic event;undergraduate student;United States National Institutes of Health;Universities;Youth

PROJECT_TITLE: Impacts of Social Determinants of Health and COVID-19 Pandemic Factors on Suicide Risk among Youth


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: Pasadena

ORG_NAME: DOHENY EYE INSTITUTE

ORG_STATE: CA

PHR: Project Narrative The proposed research is focused on how the metabolic state of different retinal ganglion cell subtypes, arising due to their energy needs, modulates their electrical excitability. By understanding the links between the cells' bioenergetic requirements, how they generate potentially harmful reactive oxygen species when making energy, and how they respond to these intrinsic metabolic signals by reducing excitability, we will identify key mechanisms that suppress metabolic crisis in the retina. This knowledge is a prerequisite for improving diagnostic assessment that may allow detection and intervention to prevent or restore vision loss due to retinal disease.

PI_NAMEs: BARNES, STEVEN ANDREW (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Action Potentials;Afferent Neurons;Axon;Bathing;Bioenergetics;Biophysical Process;biophysical properties;Blindness;Brain;Cell Physiology;Cells;Clinical;Code;Complex;cost;Data;Detection;Diagnosis;Diagnostic;Environment;Excision;Expenditure;Failure;Feedback;Frequencies;ganglion cell;Generations;Goals;Health;improved;Inherited;insight;Intervention;Investigation;Ion Channel;Ion Channel Gating;Ions;Kinetics;Knowledge;Light;Light Cell;light intensity;Link;Mediating;Membrane;Metabolic;Metabolic stress;Metabolism;Mitochondria;Modeling;Mus;National Eye Institute;Nerve Degeneration;neural;Neurons;Neurophysiology - biologic function;neuroprotection;novel;Optic Nerve;optic nerve disorder;Output;Oxidants;patch clamp;Patch-Clamp Techniques;Pathologic;Pattern;Phenotype;Play;Predisposition;prevent;Process;Production;Property;protein expression;Proteins;Reactive Oxygen Species;Research;Resolution;response;Retina;Retinal Diseases;Retinal Ganglion Cells;retinal neuron;Shapes;sight restoration;Signal Transduction;stem;Stimulus;Stress;Synapses;Testing;theories;tool;transmission process;Vision;Visual;visual information;visual stimulus;voltage;voltage clamp

PROJECT_TITLE: Retinal Ganglion Cell Signaling Regulated By Intrinsic Reactive Oxygen Species

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: RALEIGH

ORG_DEPT: OTHER CLINICAL SCIENCES

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: 8. NARRATIVE The NC State training program in Comparative Medicine and Translational Research addresses two critical national needs in biomedical research. First is the growing need for veterinarians with training in biomedical research. Second is that more emphasis needs to be placed on translation of basic research advances to the clinical setting and this often requires a multidisciplinary approach.

PI_NAMEs: SCHNABEL, LAUREN VIRGINIA (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TITLE: Comparative Medicine and Translational Research Training Program


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Dysregulation of the small GTPase Ras and its negative regulator p120RasGAP have been linked to numerous vascular diseases including capillary malformation-arteriovenous malformation syndrome (CM-AVM) and vein of Galen malformations (VOGM). Despite the importance of strict regulation of cell signaling for normal control of cell growth and proliferation, these signaling proteins are still not well understood at the molecular level. This project will investigate inter-domain regulation of p120RasGAP and its effect on Ras activity, providing new insights into the mechanisms of these diseases.

PI_NAMEs: PAUL, MAXUM  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Acceleration;Address;Affect;Affinity;Arteriovenous malformation;base;Behavior;Binding;Binding Proteins;Biochemical;Biological Assay;Birth;Blood;Blood capillaries;Blood Vessels;Brain region;C2 Domain;Calcium;cell growth;Cell Proliferation;Complex;Data;Disease;disease-causing mutation;Embryonic Development;enzyme activity;Family;flexibility;Fluorescence;Functional disorder;Galen Vein;Genes;genetic regulatory protein;GTPase-Activating Proteins;Guanosine Triphosphate Phosphohydrolases;Heart failure;improved;in silico;In Vitro;insight;Kinetics;Length;Link;Lipids;Lobe;malformation;Mediating;member;Membrane;Molecular;Molecular Conformation;Monomeric GTP-Binding Proteins;Mutagenesis;mutant;Mutation;N-terminal;Nervous System Trauma;p120 GTPase Activating Protein;Pathology;PH Domain;platelet protein P47;Play;Point Mutation;Positioning Attribute;pressure;Process;Protein Family;protein purification;Protein Region;Proteins;ras GTPase-Activating Proteins;Ras Signaling Pathway;Recording of previous events;Regulation;rho GTPase-activating protein;Role;Signal Transduction;Signaling Protein;Site;skin lesion;src Homology Domains;Structure;Syndrome;Tertiary Protein Structure;Testing;Thumb structure;Vascular Diseases;Veins;Vesicle

PROJECT_TITLE: Inter-Domain Regulation of p120RasGAP


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Social Determinants of Health;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: PROJECT NARRATIVE Exposure of pregnant women to environmental pollution and toxicants significantly increase risks to mother’s health after birth. Using already collected samples, our study will use innovative technologies and will identify the drivers of immune dysfunction and potential modifiable factors. We will determine how these immune findings are associated with pollution exposure and outcomes of disease.

PI_NAMEs: NADEAU, KARI C. (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: absorption;adverse outcome;Affect;Age;Air Pollution;ambient air pollution;Area;Asthma;ATAC-seq;Autoimmune Diseases;Automobile Driving;Bioinformatics;Birth;Blood;Blood specimen;Cardiovascular Diseases;Cells;ChIP-seq;Chronic;Clinical;cohort;Data;Data Set;Discipline of obstetrics;Disease;Disease Outcome;Eclampsia;Environmental Pollution;epidemiology study;Epigenetic Process;Experimental Designs;Exposure to;Female;Fetus;fine particles;Functional disorder;Funding;Future;Gene Expression;Growth;health of the mother;healthy pregnancy;high dimensionality;high risk;Histones;Hypersensitivity;IL27RA gene;Immune;immune health;Immune response;Immune system;Immune System Diseases;Immune Tolerance;Immunologics;Immunology;Immunosuppression;Individual;Infection;Infertility;innovative technologies;Knowledge;Link;Long-Term Effects;Lung;Malignant Neoplasms;Maps;Mass Spectrum Analysis;maternal immune system;maternal morbidity;Maternal Mortality;Measures;Metadata;Methods;Methylation;Modification;Molecular;Mothers;National Institute of Environmental Health Sciences;Outcome;parous;Particulate Matter;phenotypic biomarker;Plasma;Play;pollutant;Pollution;post pregnancy;Postpartum Period;Pre-Eclampsia;Pregnancy;Pregnancy Trimesters;pregnant;Pregnant Women;Premature Birth;Proliferating;Proteomics;Public Health;Public Policy;Publishing;Regulatory T-Lymphocyte;Research;Research Project Grants;response;Risk;Role;Sampling;Second Pregnancy Trimester;Stream;System;T cell receptor repertoire sequencing;T-Cell Receptor;T-Lymphocyte;Testing;Time;tool;Toxic Environmental Substances;toxicant;Toxicant exposure;Vulnerable Populations;Woman;Women's Health

PROJECT_TITLE: Immune Tolerance Dysfunction in Pregnancy due to Ambient Air Pollution Exposure


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Physical Rehabilitation;Rehabilitation

ORG_DEPT: PHYSICAL MEDICINE & REHAB

PHR: Project Narrative The number of individuals with movement disabilities continues to increase with a clear impact on the need for developing more effective rehabilitation interventions and devices. The continuation of this graduate program will train engineer/clinician scientists combining solid training in fundamental neurobiology and clinical physical therapy with a solid education in engineering. Graduates from this program are expected to advance the field of movement and rehabilitation sciences through basic research and device development.

PI_NAMEs: DEWALD, JULIUS P (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TITLE: Interdisciplinary Graduate Education in Movement and Rehabilitation Sciences


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pediatric;Prevention;Substance Misuse

ORG_DEPT: PSYCHOLOGY

PHR: PROJECT NARRATIVE In a world where digital media use is becoming increasingly ubiquitous in everyday life, understanding how symptomology of use can impact drug use trajectories will have critical implications for how technology is employed in education, the workspace, clinical practice, and public health. Research findings will elucidate mechanisms driving compulsive digital media use, help identify individuals at risk for substance addictions, and be an initial step toward informing interventions.

PI_NAMEs: FLANNERY, JESSICA SHANNON (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Abstinence;Ache;Acute;addiction;adolescent brain development;Affective;age group;aged;Agreement;Anhedonia;Anxiety;associated symptom;Automobile Driving;Behavior;Brain;brain based;Cellular Phone;clinical practice;Cognitive;college;common symptom;comorbidity;Computers;Corpus striatum structure;craving;cue reactivity;Cues;Data Collection;Dependence;Development;Devices;digital;digital media;drug craving;Drug usage;drug use behavior;drug withdrawal;Drug Withdrawal Symptoms;dysphoria;Education;experience;Family;Funding;Habenular Nucleus;Health;Hydrocortisone;inattention;Incentives;Individual;Individual Differences;interest;Intervention;Life;Life Experience;Link;Measurement;Measures;media use;neural;Neurobiology;Neurocognitive;neuroimaging;Neurosciences;non-drug;Outcome;Participant;Peripheral;Personality Traits;Pharmaceutical Preparations;Physiological;Physiology;Population;Postdoctoral Fellow;Prevalence;prevent;Psychological reinforcement;Psychosocial Factor;Public Health;Punishment;Recording of previous events;Recovery;Reporting;Research;Resolution;response;reward processing;Rewards;Risk;Risk Factors;Salivary;Severities;Sleeplessness;social;social norm;Social Reinforcement;Stimulus;Stream;Structure;Substance abuse problem;Substance Addiction;substance use;Substance Use Disorder;substance user;Symptoms;System;Techniques;Technology;Training;tv watching;university student;wireless fidelity;Withdrawal;Withdrawal Symptom;Work;young adult

PROJECT_TITLE: Neurobiological impact of acute digital media abstinence among drug using college students


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE In this collaborative project, we will use rigorous development methods to expand the Observer-Reported Communication Ability (ORCA) measure to 13 neurodevelopmental disorder populations. Additionally, we will provide age-based normative data from a US sample of typically developing children, evaluate other commonly used communication measures, and explore endpoint models to provide a comprehensive set of outcomes for capturing communication ability. Our ultimate goal is to provide investigators with a comprehensive set of tools to evaluate changes in communication ability in these vulnerable populations, which in turn, will help to facilitate crucial pediatric clinical trials.

PI_NAMEs: REEVE, BRYCE B (contact)

PROGRAM_OFFICER_NAME: BENT, ROBYN S

PROJECT_TITLE: Expanding the Observer-Reported Communication Ability (ORCA) Measure: Measuring the communication ability of individuals with rare, neurodevelopmental disorders


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: WASHINGTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: HOWARD UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative Insulin resistance is when cells in your muscles, fat, and liver don’t respond well to insulin and can’t easily take up glucose from your blood, a condition known as prediabetes, affecting more than 84 million people ages 18 and older in the United States, about 1 out of every 3 adults. Researchers don’t fully understand what causes insulin resistance and prediabetes, but they think that excess weight and lack of physical activity are major factors. Here, we study three models of insulin resistance in an animal model to better understand the mechanisms involved in insulin resistance related to excess fat intake, excess sugar intake, and excess androgens.

PI_NAMEs: ANDRISSE, STANLEY  (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Adult;Affect;Age;androgen excess;Androgen Receptor;Androgens;Animal Model;Blood;cardiometabolism;Cardiovascular Diseases;Cell Culture Techniques;Cells;Clinical;Collaborations;comorbidity;Complex;current pandemic;Diet;Diglycerides;Disease;Energy Metabolism;experimental study;Fatty acid glycerol esters;fatty liver disease;Female;Fructokinases;Fructose;Functional disorder;Genetic;Glucokinase;Glucose;glucose metabolism;glucose production;Glycogen;Glycogen (Starch) Synthase;glycogenolysis;Hepatic;hepatic gluconeogenesis;hexokinase;High Fat Diet;Impairment;Insulin;insulin receptor tyrosine kinase;Insulin Resistance;insulin signaling;Intake;Isotopes;Ketohexokinase;Knock-out;Knockout Mice;Lipids;Liver;male;Measurement;Metabolic;Metabolic dysfunction;Metabolic syndrome;Metabolism;Minority-Serving Institution;Modeling;Molecular;mouse model;Movement;Mus;Muscle;Non obese;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;Persons;physical inactivity;Physiology;PI3K/AKT;PIK3CG gene;Play;Polycystic Ovary Syndrome;Prediabetes syndrome;Process;Production;Protein Kinase C;protein kinase C epsilon;Proteins;Proto-Oncogene Proteins c-akt;recruit;Regimen;Regulation;Research;Research Personnel;Resistance;Role;Science;sugar;targeted treatment;Technology;Testing;Therapeutic Intervention;Tissues;Tracer;Training;Underrepresented Minority;United States;Weight;Work

PROJECT_TITLE: The cellular molecular regulation of differing mechanisms of insulin resistance.

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: ENGLEWOOD

ORG_NAME: COMMONSPIRIT HEALTH RESEARCH INSTITUTE

ORG_STATE: CO

PHR: The Catholic Health Initiatives’ Institute for Research and Innovation (CIRI) Oncology Research Alliance (CORA) is a community-based research network made up of community hospitals and cancer centers from ten states that works together to recruit and enroll patients, including those underrepresented in research, in cancer control, prevention, screening, and care delivery trails as well as quality-of-life studies. CORA also identifies, designs and implements cancer care delivery research that leads to improved models of care and translates to high quality, value- based services throughout the oncology continuum. Overall, CORA seeks to contribute to and improve cancer research and the delivery of cancer care in the community.

PI_NAMEs: SIDDIQUE, SHAHZAD  (contact)

PROGRAM_OFFICER_NAME: WHITE, VANESSA

PROJECT_TERMS: Acceleration;Access to Information;Address;Adoption;anti-cancer research;barrier to care;cancer care;Cancer Center;cancer clinical trial;Cancer Control;cancer prevention;Cancer Research Network;care delivery;Caring;Clinical Research;Clinical Trials;Collection;Communities;community based research;Community Hospitals;Community Networks;Community Outreach;community partners;community setting;Consent Forms;Country;Cultural Sensitivity;Data;data warehouse;Databases;design;Detection;Disease;Electronic Health Record;Enrollment;ethnic minority;Evaluation;Feeds;Geography;Goals;Growth;Health;Health system;Human;human subject;improved;Informed Consent;Infrastructure;innovation;Institutional Review Boards;Leadership;Legal;Malignant Neoplasms;Modeling;multidisciplinary;National Cancer Institute;Nurses;Oncologist;Oncology;participant enrollment;patient navigation;patient screening;Patients;Patterns of Care;personalized medicine;Physicians;Population;Population Heterogeneity;Positioning Attribute;Prevention;Process;programs;quality assurance;Quality of life;racial minority;recruit;Research;Research Institute;Research Personnel;research study;Research Support;Resources;response;Rural;screening;Service delivery model;Services;Site;Standardization;Structure;Study Subject;survivorship;symposium;System;Training;Translating;Translations;tumor;tumor registry;Underrepresented Populations;Work

PROJECT_TITLE: CIRI Oncology Research Alliance


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Prevention;Psychosis;Schizophrenia;Serious Mental Illness;Suicide;Suicide Prevention

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Little is known about factors impacting suicidal ideation and behavior in people with serious mental illness, nor which treatments are most effective, despite markedly increased risk of suicide in this population. This NRSA proposal uses advanced data science methods to evaluate the dynamics among potentially modifiable treatment targets related to suicide. The project particularly focuses on the role of social cognitive biases in affecting the social determinants of suicide, through network analysis adapted to high frequency data.

PI_NAMEs: PARRISH, EMMA  (contact)

PROGRAM_OFFICER_NAME: AVENILLA, FRANK R

PROJECT_TERMS: Affect;Age;Behavior;biobehavior;Bipolar Disorder;Cellular Phone;Clinical Trials;Cognitive;cognitive ability;cognitive testing;Complex;Computational Technique;Computing Methodologies;Cross-Sectional Studies;Data;Data Science;density;digital health;Ecological momentary assessment;effective intervention;Emotions;Exclusion;Face;Feedback;Feeling;Feeling suicidal;follow-up;Frequencies;Funding Mechanisms;Future;General Population;Goals;ideation;Individual;Intervention;Link;Major Depressive Disorder;Measures;Mediating;Methods;Modeling;Motivation;National Institute of Mental Health;National Research Service Awards;novel;parent project;Participant;Pathway Analysis;Perception;Persons;Population;preventive intervention;protective factors;psychologic;Psychoses;psychotic;Psychotic Disorders;psychotic symptoms;Research;Research Personnel;response;Role;Sampling;Schizoaffective Disorders;Schizophrenia;secondary analysis;Series;severe mental illness;social;Social Behavior;social cognition;social determinants;social influence;Social Perception;social relationships;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;Symptoms;theories;Time;tool;Training;training opportunity;Withdrawal;Work

PROJECT_TITLE: Dynamic Network Analysis of Social Cognition and Suicide in Psychosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_DEPT: BIOLOGY

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE Several species of bacteria adapt to the host environment by changing their morphotype which often coincides with broad changes in physiology that promotes their survival. Mycobacteroides abscessus is an emerging pathogen that presents as either a smooth or rough morphotypes which have very different behaviors in the host. This proposal aims to define the genes contributing to the difference between the two morphotypes behavior in vitro and during infection using a library of gene mutants.

PI_NAMEs: ROSS, BRITTANY N. (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Abscess;Address;Anabolism;antimicrobial;Appearance;Bacillus subtilis;Bacteremia;Bacteria;Behavior;behavior in vitro;Behavioral;Biological Assay;Cell Wall;ChIP-seq;Chronic;Communities;CRISPR interference;Data;Educational process of instructing;effective therapy;emerging pathogen;Environment;Essential Genes;Exposure to;Face;Fellowship;fitness;Gene Library;Genes;Genetic;Genetic Transcription;Genome;Growth;Human;Immunocompetent;Immunocompromised Host;improved;In Vitro;in vivo;Individual;Infection;Infectious Skin Diseases;insight;knock-down;Knowledge;Libraries;Lung;Metals;Methods;Modeling;Molecular;Molecular Genetics;Morbidity - disease rate;Morphology;Mus;mutant;Mutation;mycobacterial;Mycobacterium abscessus;Mycobacterium smegmatis;Nitric Oxide;opportunistic pathogen;Oxygen;pathogen;Pathogenicity;Pathway interactions;Patients;Phenotype;Physiological;Physiology;Postdoctoral Fellow;Pseudomonas aeruginosa;Regulon;Repression;Research;Research Training;respiratory;Respiratory Tract Infections;Scientist;skin abscess;Soft Tissue Infections;Stimulus;Stress;Surface;Technical Expertise;Technology;Testing;Training;transcriptome sequencing;transposon sequencing;Vaccines;Vibrio cholerae

PROJECT_TITLE: Probing Differences in Gene Essentiality Between Mycobacteroides abscessus Smooth and Rough Morphotypes During Infection


NIH_SPENDING_CATS: Aging;Prevention

ORG_CITY: DALLAS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative A balanced supply of deoxynucleoside triphosphates (dNTPs), the building blocks for DNA, is vital for the synthesis or repair of both nuclear and mitochondrial genomes, thereby maintaining cellular fitness. However, little is known regarding whether and how dNTP metabolism affects innate immunity. This MIRA R35 project aims to establish the role of dNTP metabolism as a new layer of innate immune regulation.

PI_NAMEs: ZHONG, ZHENYU  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Affect;Aging;Alzheimer's Disease;Apoptosis;Atherosclerosis;CASP1 gene;cell growth;cell injury;Cells;cytokine;Disease;disorder risk;DNA;Enzymes;fitness;Genetic;Genomic Instability;Goals;Gouty Arthritis;Homeostasis;Immune;immune activation;immunoregulation;Inflammasome;Inflammation;Inflammatory;Interleukin-1 beta;Knowledge;Macrophage;Macular degeneration;Malignant Neoplasms;marenostrin;Metabolic;Metabolic Pathway;Metabolism;mitochondrial genome;Muscle Cells;Natural Immunity;neoplastic cell;NF-kappa B;novel therapeutics;Nuclear;Obesity;Pathogenicity;prevent;Production;Proteins;receptor;repaired;Research;restoration;Risk Factors;Role;sensor;therapy development;tissue injury;tissue repair;Tissues;tripolyphosphate;Virus;Virus Replication

PROJECT_TITLE: Deciphering the Role of dNTP Metabolism in Innate Immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Prevention

ORG_CITY: NORMAN

ORG_NAME: UNIVERSITY OF OKLAHOMA

ORG_STATE: OK

PHR: PROJECT NARRATIVE AND RELEVANCE TO PUBLIC HEALTH Colon cancer evolution from precursor lesions is described mainly by two pathways, the adenoma-carcinoma sequence and the less understood 'alternative serrated pathway'. This application investigates the mech- anisms of the serrated pathway of human colon carcinogenesis by applying computational approaches to genomics and single cell/spatial transcriptomic data of a large cohort of precursor serrated lesions. Under- standing the precursor potential to malignancy can considerably enhance prevention, diagnosis and the clinical predictability of the serrated lesions and polyps.

PI_NAMEs: MOUSSA, MARMAR  (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: adenoma;Anatomy;Appearance;Area;ATAC-seq;Atlases;Award;Biopsy;Cancer Biology;cancer genomics;cancer invasiveness;Cancerous;carcinogenesis;Carcinoma;career;career development;Cause of Death;Cell Communication;cell community;Cells;Characteristics;Chromosomal Instability;Clinical;Clinical Markers;cohort;Collection;Colon;colon cancer prevention;colon carcinogenesis;Colon Carcinoma;Colonic Polyps;Colorectal Cancer;colorectal cancer prevention;Complex;computer scientist;Computing Methodologies;Connecticut;Data;Detection;Development Plans;Diagnosis;Dysplasia;Early Diagnosis;Epigenetic Process;Evolution;Excision;exome;experience;Formalin;Freezing;Gene Expression;Genes;Genomics;Goals;Heterogeneity;High grade dysplasia;Histologic;Histology;Histopathology;Human;human data;Hyperplasia;immune activation;immune cell infiltrate;improved;Individual;Institution;Interdisciplinary Study;Lead;Lesion;Ligands;Link;machine learning model;Malignant - descriptor;Malignant Neoplasms;Maps;Measures;Mentors;Methylation;Microsatellite Instability;MLH1 gene;Modeling;Molecular;Molecular Profiling;Morphology;multiple omics;Mutation;Neighborhoods;Normal tissue morphology;novel;Paraffin Embedding;Pathology;Pathway interactions;Patients;Pattern;Phenotype;Physicians;Polypectomy;Polyps;Positioning Attribute;Precancerous Conditions;premalignant;Prevention;Prevention program;Public Health;Publishing;receptor;Registries;Research;research and development;Research Personnel;Resolution;Risk;Sampling;Scientist;Series;single cell analysis;single cell sequencing;Specimen;System;Testing;Tissue Sample;tool;Training;transcriptomic profiling;transcriptomics;tumor;tumor microenvironment;tumor-immune system interactions;tumorigenesis;United States;Universities;Work

PROJECT_TITLE: Computational approaches to the mechanistic elucidation of the serrated pathway of human colon carcinogenesis

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Although locally invasive disease is nearly always curable, metastatic prostate cancer is usually fatal. Our research is focused on elucidating basic mechanisms that drive progression of prostate cancer to metastatic disease, with an emphasis on understanding phenotypic heterogeneity. Our emphasis on precision modeling of prostate cancer metastasis may ultimately help guide individualized patient care.

PI_NAMEs: ABATE-SHEN, CORY  (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Androgens;Cancer Biology;candidate identification;Cell Separation;Cells;Cessation of life;Characteristics;Collection;Data;deprivation;Disease;Elements;Event;gain of function;Genes;Genetically Engineered Mouse;Goals;Heterogeneity;histone methyltransferase;Human;improved;Incidence;Individual;innovation;insight;Investigation;loss of function;Malignant neoplasm of prostate;Malignant Neoplasms;Metastatic Neoplasm to the Bone;Metastatic Neoplasm to the Lung;Metastatic Prostate Cancer;Methods;Modeling;Molecular;mouse model;Mus;Mutation;Neoplasm Circulating Cells;Neoplasm Metastasis;novel;Organ;organ on a chip;Organ Specificity;Organoids;Outcome;Pathway interactions;personalized care;Phenotype;precision oncology;Primary Neoplasm;Process;Property;prostate cancer metastasis;prostate cancer model;prostate cancer progression;Prostatic Neoplasms;Research;RNA;Role;Series;Shapes;Signal Transduction;single cell analysis;single cell sequencing;Site;System;Systems Biology;Technology;Tissues;TP53 gene;transcriptomics;translational cancer research;Tropism;tumor

PROJECT_TITLE: Molecular mechanisms of prostate cancer metastasis

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Gene Therapy;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative Ischemic cardiovascular diseases are the leading cause of morbidity and mortality in the USA; however, clinical therapies aiming to grow blood vessels in the body are currently lacking. Recently, we developed innovative technologies for directly reprogramming somatic cells toward endothelial cells (rECs) using the ETV2 gene, bypassing a stem cell stage. In this proposal, we will develop a clinically compatible ETV2 vector and rECs engineered with a novel biomaterial, and determine the therapeutic effects of direct delivery of ETV2 gene and engineered rECs on ischemic animal models.

PI_NAMEs: YOON, YOUNG-SUP  (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: adult stem cell;Alginates;American;Animal Model;Area;Biocompatible Materials;Biological;Biomedical Engineering;blood vessel development;Blood Vessels;Bone Marrow;Bypass;Cardiac Myocytes;Cardiovascular Diseases;Cell Adhesion;Cell Differentiation process;Cell Lineage;Cell Survival;Cell Therapy;Cell Transplantation;cell type;Cells;cellular engineering;Clinical;clinical application;clinical translation;Clinical Trials;copolymer;cost;delivery vehicle;Dermal;design;Disease;Embryo;embryo cell;Encapsulated;Endothelial Cells;Endothelium;Engineering;Engraftment;Family;Fibroblasts;Functional disorder;Gelatin;Gene Modified;Genes;Genomics;Goals;Hepatocyte;Hindlimb;Histologic;Human;Hybrids;Hydrogels;Imaging technology;Impairment;in vivo;induced pluripotent stem cell;inflammatory milieu;Inflammatory Response;Injections;innovative technologies;Insertion Mutation;Ischemia;Lentivirus Vector;Measurement;member;Microspheres;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;Myocardial Ischemia;neovascularization;Neurons;next generation;novel;novel strategies;Organ;organ injury;particle;Patients;Peripheral Vascular Diseases;Play;poly(glycerol-sebacate);Polymers;Population;postnatal human;programs;regenerative therapy;Reporting;Research;Residual state;Role;side effect;Somatic Cell;stem cells;Technology;Therapeutic;Therapeutic Effect;therapy development;Time;tissue regeneration;tissue repair;Tissues;transcription factor;Transgenic Mice;Transplantation;tumorigenic;Tumorigenicity;Undifferentiated;Variant;Vascular regeneration;vector;Viral;Viral Vector

PROJECT_TITLE: Vascular Regeneration with Direct Reprogramming and Engineering Strategies

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Cancer

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: My future research goals are aimed at understanding how various types of cell signaling pathways, mainly phosphorylation and ubiquitination pathways, are regulated and integrated to govern protein modifications and cellular processes, and how dysregulation of these signaling pathways contributes to the pathophysiology of human disorders including cancer. Ultimately, we hope that further understanding of these critical cell signaling regulators will guide us in developing novel therapeutic approaches to combat human disorders including cancer.

PI_NAMEs: WEI, WENYI  (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Acetylation;Alternative Splicing;Antineoplastic Agents;Attention;Award;Biochemical;Biological Markers;career;Cell Cycle;Cell Cycle Regulation;Cell Physiology;cell type;Cellular Metabolic Process;combat;Complex;Cullin Proteins;Development;Disease;Drug Targeting;Enzymes;Event;FRAP1 gene;Functional disorder;Genes;genetic approach;Goals;Heart;Human;human disease;Human Genome;in vivo;inhibitor;innovation;insight;Laboratories;Malignant Neoplasms;Mediating;Methylation;Modification;Molecular;Multienzyme Complexes;new therapeutic target;next generation;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;Pathologic;Pathway interactions;Phosphorylation;Phosphotransferases;Physiological;Post-Translational Protein Processing;programs;Proteins;Proteome;proteostasis;Research;Resources;Role;Signal Pathway;Signal Transduction;targeted cancer therapy;Therapeutic;tumor;tumorigenesis;ubiquitin-protein ligase;Ubiquitination

PROJECT_TITLE: Deciphering the physiological role and interplay between ubiquitination and phosphorylation pathways to guide targeted cancer therapies


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases;Orphan Drug;Pediatric;Rare Diseases

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Project narrative To improve our understanding of mechanisms of drug action in the enteric parasite Cryptosporidium parvum, we are proposing to expose Cryptosporidium parasites to chemical mutagens or to mutagenic radiation, and select mutagenized populations for resistance to drugs. Genome sequencing will reveal genes which control drug susceptibility. This research will accelerate the discovery of drugs to treat cryptosporidiosis, one of the major causes of infant diarrhea.

PI_NAMEs: WIDMER, GIOVANNI  (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Acceleration;Acids;Affect;Animals;Applied Research;Area;Backcrossings;Basic Science;Biology;causal variant;Cells;Chemicals;Childhood;clinically relevant;Collection;CRISPR/Cas technology;Cryptosporidiosis;Cryptosporidium;Cryptosporidium parvum;Defect;Developing Countries;Development;Diarrhea;Dimensions;Dissection;drug action;Drug Controls;drug development;Drug resistance;drug-sensitive;Enteral;Ethyl Methanesulfonate;Etiology;excystation;experimental study;Exposure to;Flushing;forward genetics;Frequencies;Future;gene editing technology;Generations;Genes;Genetic;Genetic Determinism;Genome;genome editing;genome sequencing;genomic locus;Genomics;Goals;homologous recombination;Human;improved;Infantile Diarrhea;inhibitor;innovation;interest;Invaded;irradiation;low and middle-income countries;Malaria;Maps;Mediating;Medicine;Metabolic Pathway;Methods;model organism;Multi-Drug Resistance;Mus;Mutagenesis;Mutagens;mutant;Mutation;Nitrosourea Compounds;Oocysts;Oral;Outcomes Research;Output;Parasites;pathogen;Pharmaceutical Preparations;Phenotype;Piperazines;Population;Predisposition;Probability;Procedures;Proteins;Public Health;Radiation;reference genome;Research;Resistance;resistance mechanism;response;Sporozoites;Taxonomy;Techniques;Testing;tool;Toxoplasma;Toxoplasma gondii;trait;ultraviolet irradiation;Uncertainty;vaccine development;Virulence;whole genome;Work;Zoonoses

PROJECT_TITLE: Cryptosporidium mutagenesis


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: PROJECT NARRATIVE Organisms adapt to the specific demands of their environmental niche to regulate behaviors. This research exploits the octopus’ unique ability to acutely alter the structure of its proteins to understand how organisms adapt to specific behavioral states and environments. Results from this study will provide broad insight regarding how single proteins are able to integrate internal and external signals to mediate novel organismal behavior.

PI_NAMEs: SEPELA, REBECKA JANE (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Acute;Adaptive Behaviors;Adenosine;Advisory Committees;Affect;Amino Acid Sequence;Animal Behavior;Animals;Architecture;arm;arm movement;Behavior;Behavioral;Behavioral Assay;Binding;Biochemical;Biology;biophysical properties;Biophysics;Cell Physiology;Cells;Cephalopoda;Chemicals;Code;Cryoelectron Microscopy;Data;Dependence;Detection;dsRNA adenosine deaminase;Electrophysiology (science);Environment;Enzymes;Epigenetic Process;epigenetic regulation;Esthesia;Evolution;Exhibits;experimental study;Family;flexibility;Floor;Genes;Genomics;Guanosine;Hour;Hunger;Individual;Inosine;insight;Ion Channel;Ions;Learning;Ligands;Measures;Mediating;Messenger RNA;Molecular;mRNA Translation;Mutagenesis;Nervous System;neurotransmission;Neurotransmitter Receptor;novel;Octopus;Open Reading Frames;Organism;patch clamp;pharmacologic;Physiological;polypeptide;Polyribosomes;post-doctoral training;Process;Property;protein function;protein structure;Proteins;Proteome;Proteomics;receptor;receptor function;receptor sensitivity;Research;response;Ribosomes;RNA;RNA Editing;RNA Sequences;Sea;Sensory;Sensory Receptors;sensory system;Signal Transduction;Site;Specialist;Starvation;Stimulus;Structure;Taste Perception;Techniques;Testing;Touch sensation;Training;trait;Transcript;transcriptomics;Translating;Translations;Variant;voltage

PROJECT_TITLE: Molecular tuning of sensory systems in octopus


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Cannabinoid Research;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Natural Products;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Narrative The research work if completed will determine the 3D structure of allosteric binding sites for cannabinoid receptor 2 (CB2), a significantly important drug target for treatment of diseases and disorders in which the role of CB2 is implicated (such as pain, osteoporosis, autoimmune diseases and certain cancers), and allow for novel CB2 allosteric modulators to be produced via computationally-guided medicinal chemistry.

PI_NAMEs: XIE, XIANG-QUN  (contact);ZHANG, CHENG

PROGRAM_OFFICER_NAME: HILLERY, PAUL

PROJECT_TERMS: 3-Dimensional;addiction;Affinity;Agonist;Algorithms;Allosteric Site;alternative treatment;antagonist;Antibodies;Autoimmune Diseases;Binding;Binding Sites;Biological Assay;Biology;Brain region;cannabinoid receptor;Cannabinoids;Chemicals;cheminformatics;Chronic;CNR1 gene;CNR2 gene;Complex;computational chemistry;Cryoelectron Microscopy;Cyclic AMP;Databases;deep learning;design;Detergents;Development;Disease;Docking;drug development;drug discovery;Drug Targeting;endogenous cannabinoid system;Exhibits;Family;G-Protein-Coupled Receptors;Genomics;Goals;GTP-Binding Proteins;Heterogeneity;Human;Hydrophobicity;Immune;improved;in silico;In Vitro;in vivo;Inflammatory;innovation;insight;interest;Joints;learning classifier;Legal patent;Libraries;Ligand Binding;Ligands;Machine Learning;machine learning classifier;Malignant Neoplasms;Measures;Membrane Proteins;Methods;Modeling;Molecular;Molecular Conformation;Molecular Profiling;Mutation;neuroinflammation;Neurologic;novel;Osteoporosis;Outcome;Pain;Pharmaceutical Chemistry;Pharmacology;pharmacophore;Pilot Projects;positive allosteric modulator;pressure;prevent;Property;prospective;prototype;Publications;Publishing;receptor;Reporting;Research;Resistance development;Roentgen Rays;Role;screening;Signal Transduction;Site;Site-Directed Mutagenesis;small molecule;small molecule libraries;spatiotemporal;structural biology;Structure;Synthesis Chemistry;synthetic cannabinoid;System;targeted treatment;Techniques;Technology;Therapeutic;therapeutic target;three dimensional structure;Tissues;tool;Validation;virtual;Work;X-Ray Crystallography

PROJECT_TITLE: Cannabinoid CB2 Receptor Structure and Allosteric Modulators

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: IMPACT CENTER NARRATIVE The goal of the IMPACT Center: Optimizing Evidence-Based Practice Implementation for Clinical Impact, is to increase high-fidelity delivery of evidence-based practices (EBPs) for youth receiving mental healthcare in low- resource community settings. IMPACT Center's approach is to optimize EBP implementation in community set- tings by partnering with stakeholders to develop practical implementation strategies, methods, and resources for the practice and scientific communities. We focus on three challenges to high-fidelity EBP delivery: (I) Identify and prioritize determinants of practice; (II) Match strategies to prioritized determinants; and (III) Optimize strate- gies. Our research will have a strong impact on public health by enhancing treatment quality in the service of improving clinical outcomes for youth.

PI_NAMEs: DORSEY, SHANNON  (contact)

PROGRAM_OFFICER_NAME: LUSHIN, VICTOR

PROJECT_TERMS: Acceleration;Address;Adolescent;adverse outcome;Anthropology;Anxiety;Behavioral;behavioral health;Caring;Child;Client;Clinical;clinical implementation;Cognitive Therapy;Collaborations;Communication;Communities;Community Mental Health Centers;Community Practice;community setting;computer science;Consultations;Data;design;dissemination strategy;editorial;Education and Outreach;Effectiveness;Ensure;ethnic diversity;Evaluation;Evidence based practice;Evidence based treatment;Familiarity;Family;Fostering;Funding;Goals;Grant;Health;Impact evaluation;implementation barriers;implementation research;implementation science;implementation strategy;improved;Information Sciences;innovation;Knowledge;Laboratories;Lead;Leadership;Learning;Lifelong disability;Low income;Measurement;Medicine;Mental Depression;Mental Health;Mental Health Services;Methods;Morbidity - disease rate;mortality;Outcome;outreach;peer;Pilot Projects;post-traumatic stress;pragmatic implementation;preference;programs;Provider;Psychology;Public Health;Public Health Practice;Recording of previous events;Recovery;Research;Research Institute;Research Personnel;Resource-limited setting;Resources;Schools;Science;Services;skills;synergism;Testing;Time;tool;Training;Trauma;Universities;user centered design;user-friendly;Washington;web site;Youth

PROJECT_TITLE: Optimizing Evidence-Based Practice Implementation for Clinical Impact: the IMPACT Center


NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Health Services;Mental Health

PROJECT_TERMS: Acceleration;Address;Advisory Committees;Applications Grants;Area;clinical implementation;clinical practice;Collaborations;Communication;Communities;Community Practice;community setting;Dedications;design;Dissemination and Implementation;E-learning;Education and Outreach;Educational Status;Educational workshop;Effectiveness;Electronic Mail;Ensure;Environment;Evaluation;Evidence based practice;experience;Faculty;Family;Fellowship;Fellowship Program;formative assessment;Fostering;Foundations;Funding;Future;Goals;graduate student;Grant;Growth;Health Benefit;health care delivery;Hour;implementation research;implementation science;implementation strategy;improved;Knowledge;Lead;Learning;massive open online courses;meetings;Mental Health;Mental Health Services;Mentors;Methods;Monitor;National Institute of Mental Health;Outcome;outreach;Paper;Pathway interactions;Persons;Pilot Projects;Policies;Postdoctoral Fellow;pragmatic implementation;Process;programs;Public Health;Publishing;Recommendation;relational database;Research;Research Institute;Research Personnel;Resource-limited setting;Resources;Services;Site Visit;skills;Societies;Specialist;Strategic Planning;student mentoring;Students;Sum;symposium;synergism;System;Testing;timeline;Training;training opportunity;Training Programs;Update;Visit;Visual;Voice;web site;Youth


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: BLACKSBURG

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

PHR: PROJECT NARRATIVE The overall goal of this grant is to investigate the contributions of mitochondrial diversity as a regulator of cell- and circuit-specific functions. The work from this grant is expected to link the distinct mitochondrial bioenergetic signature of CA2 neurons to the unique molecular and cellular mechanisms underlying CA2 function in learning and memory. Completion of this project will advance our understanding of mitochondrial heterogeneity in a cell type important for social memory and will identify novel therapeutic candidates for disorders with social deficits, such as schizophrenia and autism.

PI_NAMEs: FARRIS, SHANNON  (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Address;Affect;Area;Attention;autism spectrum disorder;Automobile Driving;Bioenergetics;Biological;Body System;Brain;Brain Diseases;brain health;Buffers;Calcium;calcium uniporter;cell type;Cells;Citric Acid Cycle;Complex;Cytoplasm;Data;Dendrites;Disease;Distal;Electron Transport;Energy-Generating Resources;Enzymes;Foundations;Gene Expression Profile;Generations;Genes;Genetic;Goals;Grant;Heterogeneity;hippocampal pyramidal neuron;Hippocampus;innovation;insight;Knockout Mice;Knowledge;Label;Learning;Light;Link;Long-Term Potentiation;Mediator;Memory;Mitochondria;Molecular;Morphology;neural;Neurons;Neurophysiology - biologic function;novel therapeutics;Ontology;overexpression;Pathology;Phenotype;Play;Process;Property;Recruitment Activity;Regulation;Research Proposals;Resistance;Respiration;Role;Schizophrenia;Site;social;social deficits;Superoxides;Synapses;Testing;therapeutic candidate;tool;Transcript;transcriptome;uptake;Visualization;Work

PROJECT_TITLE: Mitochondrial diversity as a regulator of cell- and circuit-specific functions

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Genetics

PHR: Project Narrative Our research is relevant to the NIH mission to seek fundamental knowledge about the nature and behavior of living systems. We seek to understand hormone-mediated modulation of gene activation or repression through transcription factors. Because this process is central to all systems, identifying mechanisms that regulate transcriptional activity in one organism may be broadly informative to all organisms.

PI_NAMEs: STRADER, LUCIA  (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: 4-ethoxymethylene-2-phenyl-2-oxazoline-5-one;Automobile Driving;Auxins;Back;Behavior;Binding;Biochemistry;Biophysics;Charge;Chromatin Remodeling Factor;Complex;Cullin Proteins;derepression;Development;Disease;Electrostatics;Event;F Box Domain;F-Box Proteins;Face;Family;Gene Activation;gene repression;Genetic;Genetic Transcription;Hormones;insight;interdisciplinary approach;Knowledge;Ligands;Mediating;member;Mission;Modeling;Molecular;Nature;Organism;Phase Transition;Physical condensation;plant growth/development;Plants;Point Mutation;Positioning Attribute;Process;protein degradation;protein folding;Proteins;Reagent;receptor;recruit;Regulation;Repression;Repressor Proteins;Research;response;Side;Signal Transduction;Structure;System;Transcription Coactivator;transcription factor;Transcription Repressor;Transcriptional Regulation;transport inhibitor;ubiquitin-protein ligase;United States National Institutes of Health

PROJECT_TITLE: Auxin Response Factors as a model of transcriptional control

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


NIH_SPENDING_CATS: Clinical Research;Genetics;Maternal Health;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: NARRATIVE Spontaneous preterm birth is a leading cause of neonatal morbidity and mortality, yet we lack the means to diagnose it in advance, treat, or prevent it, especially in women giving birth for the first time. We will analyze samples from one of the best-phenotyped cohorts of nulliparous pregnant women, the nuMoM2b study, providing the largest sample size of its kind along with detailed clinical data affording a nuanced view of prematurity. Our study will identify new biomarkers for early identification of preterm birth, and potential mechanisms underlying it, through a high-resolution investigation of the microbes and small molecules in the female reproductive tract.

PI_NAMEs: KOREM, TAL  (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: 16S ribosomal RNA sequencing;adverse pregnancy outcome;Affect;Algorithms;Biological;Biological Markers;biomarker identification;Cervix Incompetence;Characteristics;Clinical;clinical application;Clinical Data;clinical translation;cohort;Communities;computer framework;Data;Data Analyses;Data Set;Demography;Detection;Diagnosis;Early Diagnosis;Early identification;Early treatment;Ecosystem;Etiology;experience;female reproductive tract;First Births;First Pregnancy Trimester;Geography;Goals;Growth;gut microbiome;Heterogeneity;High-Risk Pregnancy;host microbiome;innovation;insight;Investigation;Knowledge;lens;Measures;Mediator;Medical;Metabolic;Metabolic Pathway;Metabolism;metabolome;metabolomics;metagenome;metagenomic sequencing;Metagenomics;Methods;Microbe;microbial;Microbial Genetics;microbial genomics;Microbial Taxonomy;microbiome;microbiome analysis;microbiome research;Modeling;Multicenter Trials;neonatal morbidity;Neonatal Mortality;Nulliparity;Pathology;personalized risk prediction;Phenotype;Pregnancy;Pregnancy Outcome;Pregnant Women;premature;Premature Birth;preterm premature rupture of membranes;Prevalence;prevent;Property;Race;reproductive tract;Research;Research Personnel;Resolution;Resources;Role;Sample Size;Sampling;Second Pregnancy Trimester;small molecule;Swab;System;Taxonomy;Therapeutic;Third Pregnancy Trimester;Time;United States;Vagina;vaginal microbiome;Variant;Woman

PROJECT_TITLE: A large scale investigation of the vaginal metagenome and metabolome and their role in spontaneous preterm birth

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Dissemination and Implementation Research;Mental Health;Pediatric

PI_NAMEs: WEINER, BRYAN J. (contact)

PROJECT_TERMS: Address;Adolescent;Award;Bibliography;Books;Child;Clinical;clinical implementation;clinical practice;Code;Collaborations;Communities;community academic partnership;Community Practice;Conceptions;Consult;Consultations;Data;data management;Databases;design;Development;Dissemination and Implementation;Early Diagnosis;Educational workshop;Ethnography;Evaluation;Evidence based practice;Faculty;follow-up;Goals;Grant;Guidelines;Health Benefit;Health Policy;Health Services Research;Hour;human subject;implementation determinants;implementation efforts;implementation research;implementation science;implementation strategy;improved;innovation;Measures;meetings;Mental Health;Mental Health Services;Methodology;Methods;Monitor;novel;Outcome;Pathway interactions;Pilot Projects;Policy Making;posters;Productivity;Protocols documentation;Public Health;relational database;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Resources;Safety;Scanning;Science;Societies;Surveys;symposium;technology development;Testing;Training Support;user centered design;user-friendly;Washington;web site;Work;Youth


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative This project will use high-resolution functional neuroimaging and human intracranial recordings to delineate the contributions of the dorsal and ventral subregions of the posterior cingulate cortex (PCC) to episodic memory. This research will test the hypothesis that the dorsal PCC serves as a putative accumulator of mnemonic information in support of memory-based decisions, while the ventral PCC supports the retrieval of mnemonic details and associations from previous episodes. Abnormalities in the function and structure of the PCC are associated with neurodegenerative diseases (e.g. Alzheimer’s disease), and further understanding of the precise functional organization of the PCC will help to both better understand cognitive deficits that characterize disease progression and to inform more precise interventions aimed at mitigating these deficits.

PI_NAMEs: KOSLOV, SETH RYAN (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Address;Alzheimer's Disease;Anatomy;Autobiography;Biological;cell type;Cells;cingulate cortex;Code;Cognition;Cognitive deficits;cognitive process;Complement;Coupled;Data;Data Analyses;Data Collection;Data Set;Decision Making;Disease;Disease Progression;Dissociation;Dorsal;Electrodes;Electrophysiology (science);Episodic memory;Exhibits;experience;experimental study;Frequencies;Functional Magnetic Resonance Imaging;healthy aging;Hippocampus;Human;Image;improved;Individual;insight;Intervention;Lateral;Link;Literature;Location;Magnetism;Maps;Measurement;Medial;medial temporal lobe;Memory;Memory impairment;memory process;memory retrieval;Meta-Analysis;Methods;multimodality;neocortical;neural;Neurodegenerative Disorders;neuroimaging;Neurons;neuropathology;Parietal Lobe;Participant;Pattern;Population;prevent;Process;Ramp;Rare Lesion;Research;Research Personnel;Resolution;response;Response Latencies;Retrieval;Role;Semantics;Signal Transduction;Site;skills;spatiotemporal;Structure;Surface;Techniques;Temporal Lobe;Testing;theories;Training;Visual;Work

PROJECT_TITLE: Multimodal dissociation of posterior cingulate cortex contributions to episodic memory


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: HADLEY

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: Project Narrative The ability to design, control and engineer materials and biological systems drives the development of innovative knowledge, tools and processes for advanced biotechnology in the pharma, medical devices and diagnostics industries. To achieve this goal, we must train the next generation of innovators who can be productive members of interdisciplinary teams working to translate fundamental science into products and services for human health. The UMass Amherst Biotechnology Training Program in Applied Life Sciences will continue to provide students from a variety of life sciences and engineering/physical sciences backgrounds with novel training in biotechnology, inspiring them to consider industrial relevance and translational science, and preparing them to enter the workforce with an integrated perspective about the role of biotechnology in society.

PI_NAMEs: HARDY, JEANNE ANN (contact);KULKARNI, ASHISH A.

PROGRAM_OFFICER_NAME: DAVANI, BEHROUS

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Mental Health;Pediatric;Telehealth

PI_NAMEs: LYON, AARON ROBERT (contact)

PROJECT_TERMS: analog;Articulation;Attitude;behavior change;Behavior Control;Belief;Characteristics;Client;Climate;Clinical;clinical implementation;Cognitive Therapy;Collaborations;Community Practice;community setting;confirmatory trial;Consultations;design;Development;digital;digital delivery;digital platform;Education;effective intervention;Effectiveness;eHealth;Enrollment;Evidence based practice;Family;Feedback;Funding;Goals;Hour;implementation efforts;implementation strategy;improved;Individual;innovation;Intervention Studies;Investments;Leadership;Link;Measures;Mental Health;Mental Health Services;Methods;Modeling;Motivation;motivational enhancement therapy;National Institute of Mental Health;optimism;Organizational Change;Outcome;Pathway interactions;Persons;Procedures;Proliferating;Provider;provider behavior;Public Health;randomized trial;Randomized, Controlled Trials;Research;Research Project Grants;Resource-limited setting;Resources;Rest;Schools;Science;Series;social influence;social norm;Students;teacher;Testing;theories;Training;Trauma;universal prevention;Washington;web-enabled;Youth

PROJECT_TITLE: Project 3


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Eye Disease and Disorders of Vision;Infectious Diseases;Neurosciences;Rare Diseases

ORG_CITY: PORTLAND

ORG_DEPT: NEUROLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Ebolaviruses are among the deadliest pathogens known to man, with a mortality rate of 25–90% depending on the outbreak. The proposed research seeks to elucidate brain and eye complications of Ebola infection and build capacity for Ebola research in the Democratic Republic of Congo (DRC), which has been the epicenter of the 2nd largest outbreak of Ebola virus disease (EVD) worldwide, and endured a total of 11 recorded outbreaks in the country as of November 2020.

PI_NAMEs: MUMBA, NGOYI ;MWANZA, JEAN-CLAUDE ;TSHALA-KATUMBAY, DANIEL DESIRE (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Acute;Address;Aftercare;Age;Antibody Response;Attention;Auditory;Biological Assay;Biological Markers;Biomedical Research;Brain;Case Fatality Rates;Cells;Cessation of life;Cicatrix;clinically relevant;cognitive skill;Color Visions;computerized;Congo;Contrast Sensitivity;Corneal Diseases;Country;cytokine;Death Rate;Democratic Republic of the Congo;Disease;Disease Outbreaks;Disease Progression;disorder prevention;Ebola;Ebola Hemorrhagic Fever;Ebola virus;Enzyme-Linked Immunosorbent Assay;Evaluation;experience;Eye;follow-up;Genetic;global health;Goals;Health;Human;Human Milk;Immune;immune activation;Immune System Diseases;Immunoglobulin G;Immunologics;improved;Individual;Infection;Inflammatory;inflammatory marker;instrument;Knowledge;Life;man;Measures;Mediating;men;Mental Depression;Mental Tests;Mission;Molecular Biology;Monoclonal Antibodies;National Institute of Allergy and Infectious Disease;National Institute of Neurological Disorders and Stroke;Neurocognition;Neurocognitive;non-verbal;Onset of illness;Optical Coherence Tomography;Organ;Outcome;Participant;pathogen;Performance;Plasma;Proteins;Psychophysics;Recovery;Recurrence;remdesivir;Reporting;Research;research and development;response;Retina;Reverse Transcriptase Polymerase Chain Reaction;RNA chemical synthesis;Seminal fluid;Survival Rate;Survivors;Symptoms;System;Testing;Time;Uncertainty;United States National Institutes of Health;Uveitis;Viral Load result;Virus Diseases;Virus Inhibitors;Virus Replication;Vision;Visual;Visual Acuity;Visual Fields;Visual Pathways;Woman;Work

PROJECT_TITLE: NeuroEbola


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD);Neurosciences;Rehabilitation

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Clinical circumstances that allow for chronic recordings from and stimulation of deep brain areas provide a rare opportunity to investigate neural mechanisms underlying freely moving behaviors in humans. The results from the proposed studies will bring in line major discoveries in rodent physiology with the human medial temporal lobe system underlying spatial navigation and memory. These translational studies will address questions about the relationship between deep brain stimulation, oscillatory activity, spatial navigation, and memory, and help lay the foundation for future treatments for illnesses marked by memory impairment.

PI_NAMEs: SUTHANA, NANTHIA A (contact)

PROGRAM_OFFICER_NAME: GEBREHIWET, HERMON RUSSOM

PROJECT_TERMS: Address;Alzheimer's Disease;Animals;Area;Augmented Reality;Basic Science;Behavior;Behavioral;body position;Brain;brain research;Chiroptera;Chronic;Clinical;Clinical Sciences;Clinical Treatment;Cognitive;Collaborations;Coupling;Deep Brain Stimulation;Development;Devices;Disease;Electrodes;Electroencephalography;Electrophysiology (science);Environment;Epilepsy;Eye;Eye Movements;Foundations;Functional Magnetic Resonance Imaging;Future;gray matter;Head Movements;Hippocampus;Human;Impairment;Implant;innovation;insight;Institution;Learning;Location;Measurement;Measures;medial temporal lobe;Memory;Memory Disorders;Memory impairment;Methodology;Methods;Morphologic artifacts;Motion;Movement;Nature;neuroimaging;neuromechanism;Neurons;neurophysiology;Neurosciences;next generation;nonhuman primate;novel;open source;Participant;Patients;Pattern;Performance;Physiology;Positioning Attribute;Prevalence;programs;Protocols documentation;Research;research clinical testing;research study;Rodent;Role;Route;Scientist;Source Code;spatial memory;Stimulus;Structure;System;Technology;Testing;theories;Therapeutic;Time;translational study;virtual;Virtual and Augmented reality;visual tracking;walking speed;way finding;wearable device;white matter;wireless

PROJECT_TITLE: Neurostimulation and Recording of Real World Spatial Navigation in Humans


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE During the development of an organism, proliferating cells must replicate both their genome and the histones that package it. This proposal aims to gain mechanistic insight into how expression, specifically transcriptional repression, of replication-dependent histone genes is connected to the cell cycle and regulated and to determine how aberrant expression of histones affects the development of an organism. The principles uncovered from these studies will increase our understanding of the regulation of histone biosynthesis and provide insight into the role of histone regulation on the development of organisms.

PI_NAMEs: GEISLER, MARK STEPHEN (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Affect;Anabolism;ATAC-seq;Binding;Biological Models;Biotin;C-terminal;Cell Cycle;Cell Cycle Arrest;Cell Cycle Progression;Cell Physiology;Cell Proliferation;cell type;Cells;Cellular biology;Chromatin;Chromatin Structure;Cleavage Under Targets and Release Using Nuclease;Code;Coupled;Couples;Data;design;Development;Diploidy;DNA;DNA biosynthesis;DNA Damage;DNA Packaging;Drosophila genus;Drosophila Proteins;Embryo;embryo tissue;Eukaryota;Eukaryotic Cell;experimental study;fluorescence imaging;follow-up;G2 Phase;Gene Cluster;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic;genetic manipulation;Genetic Transcription;Genome;genome integrity;Genomics;Goals;Histones;Homologous Gene;Human;insight;interdisciplinary approach;Knowledge;Label;Lead;Liquid substance;M cell;Mass Spectrum Analysis;Mediating;Messenger RNA;Molecular;mosaic;mutant;Mutation;Normal Cell;Nucleosomes;null mutation;Organism;Phase;Phenotype;Point Mutation;Postembryonic;Process;Production;Proliferating;Protein Biosynthesis;Proteins;Proteomics;Radial;Regulation;Repression;Research;Role;S phase;SANT Domain;Structure;Techniques;Testing;Tissues;tool;Toxic effect;Transcript;Transcriptional Activation;Variant;Work;Yeasts

PROJECT_TITLE: The Mute button: Turning down the volume of histone expression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-A(20)L]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Post-Traumatic Stress Disorder (PTSD);Prevention;Social Determinants of Health;Substance Misuse;Underage Drinking;Violence Against Women;Violence Research;Women's Health Research;Youth Violence;Youth Violence Prevention

ORG_CITY: MILWAUKEE

ORG_NAME: UNIVERSITY OF WISCONSIN MILWAUKEE

ORG_STATE: WI

PHR: Project Narrative Alcohol use and intimate partner violence (IPV) are major public health concerns that often coincide during adolescence to young adulthood and can be exacerbated by simultaneous symptoms of depression or post- traumatic stress. The present proposal will examine (1) the bidirectional association between alcohol use and IPV perpetration and victimization, (2) symptoms of depression or post-traumatic stress as potential moderators in the relationship between alcohol use and IPV perpetration and victimization, and (3) whether these relationships change as a function of sex assigned at birth, race, and ethnicity. Eleven years of pre- existing longitudinal annual data of adolescents (age 15) to young adults (age 26) will be used to explore the study aims to inform culturally sensitive prevention and interventions aimed at reducing intimate partner violence.

PI_NAMEs: GROCOTT, LAUREN  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Address;Adolescence;Adolescent;Adolescent and Young Adult;Adopted;Adult;African American;Age;Alcohol consumption;alcohol risk;Alcohols;Birth;conflict resolution;coping;coping mechanism;critical developmental period;Data;Data Collection;Data Set;dating behavior;depressive symptoms;design;Development;Disinhibition;Distress;drinking;early adolescence;early alcohol use;emerging adulthood;ethnic diversity;Ethnic Origin;experience;Female;Future;Intervention;intervention program;intimate partner violence;Latinx;Literature;Mental Depression;Mental Health;Pathway interactions;Pattern;Persons;post-traumatic stress;Post-Traumatic Stress Disorders;post-traumatic symptoms;Prevention;Prevention program;prospective;psychologic;Public Health;Race;racial diversity;Recovery;Research;Risk;Role;Sampling;sex;sex assigned;Surveys;Symptoms;theories;Time;Victimization;Violence;violence perpetration;violence prevention;violence victimization;young adult

PROJECT_TITLE: Alcohol Use and Mental Health as Predictors of Intimate Partner Violence from Adolescence to Young Adulthood


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Kidney Disease;Precision Medicine

ORG_CITY: Aurora

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: The proposed research is relevant to public health because acute kidney disease (AKI) and chronic kidney disease (CKD) are widespread problems that are both associated with significant morbidity and increased mortality. Currently, supportive care is the only therapeutic option for these diseases. The experiments in this proposal will improve our understanding of the mechanisms of AKI and CKD, and they may lead to effective new therapies.

PI_NAMEs: HSIEH, WEN-YUAN E;THURMAN, JOSHUA M (contact)

PROGRAM_OFFICER_NAME: GIPSON, DEBBIE SUE

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;Albuminuria;analytical method;Anatomy;anti-cancer research;Atlases;Award;Bioinformatics;Biological;Biological Assay;Biological Sciences;Biopsy;Biopsy Specimen;Cancer Biology;candidate marker;cell type;Cells;Chronic Kidney Failure;Clinical Data;Colorado;Creatinine;Development;Diagnosis;Disease;Etiology;experimental study;Expression Profiling;Funding;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genetic Complementation Test;Genetic Transcription;Goals;hemodynamics;high dimensionality;Human;Immune;Immunologist;Immunology;Immunotherapy;improved;Injury;injury and repair;innovation;insight;Interdisciplinary Study;Kidney;kidney biopsy;Kidney Diseases;Location;Maps;Medical;medical schools;Methods;Molecular;Molecular Profiling;Morbidity - disease rate;Morphology;mortality;multidimensional data;multiple omics;Multiplexed Ion Beam Imaging;novel;novel diagnostics;novel therapeutic intervention;novel therapeutics;Pathologic Processes;Pathologist;Pathway interactions;Patients;Pattern;Phenotype;precision medicine;Process;protein expression;Proteins;proteomic signature;Proteomics;Public Health;renal damage;Renal function;Research;Resolution;Resources;RNA;Serum;Site;Standardization;Structure;Supportive care;Systems Biology;Technology;Testing;Therapeutic;therapeutic target;Tissue atlas;Tissues;tool;transcriptome;transcriptomics;Translating;tumor;Universities;Widespread Disease

PROJECT_TITLE: Spatial Mapping of Proteomic and Transcriptional Signatures in Kidney Disease


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: DURHAM

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Proper brain development requires the cooperation of neurons and glial cells. One form of this cooperation is neuronal contact with astrocytes, which induces astrocyte morphological and transcriptional maturation. This proposal will test how epigenetic histone modifications act as a mechanism linking neuronal contact to astrocyte maturation.

PI_NAMEs: SAVAGE, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Address;Adhesions;Astrocytes;autism spectrum disorder;Bar Codes;Binding Sites;Brain;Cell Adhesion Molecules;Cell Nucleus;cell type;Cellular biology;ChIP-seq;Chromatin;chromatin immunoprecipitation;chromatin modification;Chromatin Remodeling Factor;Coculture Techniques;Complex;CRISPR-mediated transcriptional activation;Data;Development;DNA;Doctor of Philosophy;Enzymes;EP300 gene;Epigenetic Process;epigenetic regulation;experience;experimental study;Fibroblasts;Flow Cytometry;Follow-Up Studies;Future;Gene Expression;Gene Expression Regulation;Genes;genetic manipulation;Genetic Transcription;Genome;genomic locus;Genus Mentha;Germ Lines;histone methyltransferase;histone modification;Histones;Homeostasis;Immunoprecipitation;Impairment;indexing;Infiltration;Knock-out;Knockout Mice;Knowledge;Life;Link;LoxP-flanked allele;Measures;Mediating;member;Methanol;Methods;Methylation;Methyltransferase;MLL gene;Modification;Molecular;Morphogenesis;Morphology;Mus;Nature;nerve stem cell;Neurodevelopmental Disorder;neurogenesis;Neuroglia;neuroligin 2;neuronal circuitry;Neurons;Neuropil;novel;overexpression;pharmacologic;postnatal;prevent;Rattus;Signal Transduction;Synapses;synaptic function;synaptogenesis;Techniques;Testing;Training;transcriptome;transcriptome sequencing;Wild Type Mouse;Work

PROJECT_TITLE: How does neuronal contact mediate astrocyte transcriptional maturation?

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F03A-E(20)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Serious Mental Illness;Social Determinants of Health;Suicide

ORG_CITY: FAIRFAX

ORG_NAME: GEORGE MASON UNIVERSITY

PHR: Project Narrative This project will help us to understand bidirectional relations between parental experiences of burden (i.e., difficulties perceived to be caused or exacerbated by a child's psychiatric symptoms) and their adolescents’ mental health service use following psychiatric hospitalization, with attention to the effect of socioeconomic status on this association. This study will employ a mixed methods design with a sample of 252 mothers of recently hospitalized adolescents. Findings may be used to improve the cultural responsiveness of care coordination and intervention post-hospitalization which may reduce health disparities, youth suicide risk, and the substantial burden associated with youth psychiatric hospitalization.

PI_NAMEs: HARRIS, KATHERINE MAULTSBY (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Address;Adolescent;adolescent mental health;Age;age group;Attention;Attenuated;care coordination;career;Caring;Cause of Death;Child;Child Care;Clinical;Code;Communities;Community Mental Health Services;comparative;coping;Data;Dedications;Demographic Factors;design;Discrimination;Disparity;Distress;Doctor of Philosophy;Economics;Educational workshop;Ethnic Origin;experience;Face;Family;family burden;Family Relationship;follow-up;Goals;hands on research;health disparity;health service use;high risk;hospital readmission;Hospitalization;Hospitalized Adolescent;Household;improved;Income;inpatient psychiatric treatment;inpatient service;Interview;Investigation;Knowledge;Literature;Lived experience;low socioeconomic status;lower income families;Medical;meetings;Mental Health;Mental Health Services;Mentorship;Methods;Modeling;Monitor;Mothers;National Institute of Mental Health;Outpatients;Parents;Pattern;Perception;phenomenological models;Play;Population;post intervention;Posttraumatic growth;Process;psychiatric inpatient;psychiatric symptom;Psychopathology;Public Health;Quality of Care;Race;Random Allocation;Reaction;Recovery;Reduce health disparities;Relapse;Reporting;Research;research based treatment;research data dissemination;research study;Research Support;Research Training;Risk;Role;Sampling;service utilization;Services;Shapes;skills;social stigma;socioeconomic disparity;Socioeconomic Status;statistics;Stress;stressor;Structure;suicidal risk;Suicide;Suicide attempt;Symptoms;Time;Training;Transportation;Trauma;treatment program;treatment research;Underserved Population;Well in self;Work;Youth

PROJECT_TITLE: A mixed-methods investigation of parental burden and adolescent service use following discharge from psychiatric hospitalization


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Lung;Lung Cancer;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Lung cancer is the leading cause of cancer death in the United States, in part because of our lack of understanding of its etiology, epidemiology, and disparities based on race or ethnicity. Our research aims to characterize the landscape of ancestry effects on lung cancer evolution, and understand the mechanisms underlying the genomic disparities. Our findings will provide implications for lung cancer outcomes and enable the discovery of novel biomarkers to improve prognostics and precision medicine, particularly for the minority populations.

PI_NAMEs: ZHANG, JIAN  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Address;Admixture;Advisory Committees;African;ancestry analysis;Argentina;Asian ancestry;Automobile Driving;Award;BRAF gene;Brazil;Cancer Biology;cancer epidemiology;Cancer Etiology;cancer genome;cancer genomics;cancer health disparity;cancer initiation;Cancer Patient;cancer prevention;cancer type;career;Career Mobility;Carrots - dietary;Cessation of life;Clinical;Clinical Data;Clinical Oncology;clinical sequencing;cohort;Collaborations;Colombia;Computational Biology;Computing Methodologies;Country;Dana-Farber Cancer Institute;Data;Data Set;Development;Development Plans;Disparity;DNA Sequence Alteration;Early Diagnosis;Early treatment;East Asian;Environment;Environmental Exposure;Epidemiology;epidemiology study;Epidermal Growth Factor Receptor;ERBB2 gene;Ethnic Origin;Etiology;European;Evolution;Experimental Designs;FBXW7 gene;Foundations;Frequencies;Gene Mutation;Genetic;Genomic approach;genomic locus;Genomic Segment;Genomics;Germ Lines;Goals;Grant;Heritability;Immune;Immunotherapy;improved;Incidence;Induced Mutation;innovation;insight;Institution;Joints;KRAS2 gene;Laboratories;Latin American;Leadership;Lung Adenocarcinoma;Malignant neoplasm of lung;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Medicine;Mentorship;method development;Mexico;migration;Minority Groups;minority patient;Modernization;Mutation;Native American Ancestry;neoplasm resource;never smoker;novel;novel marker;Outcome;Pathway interactions;Patients;Pattern;Peru;Population;Population Genetics;precision medicine;Prevention;Process;prognostic;Race;RAS genes;Ras/Raf;Receptor Protein-Tyrosine Kinases;Reporting;Research;response;Sampling;small molecule inhibitor;Statistical Methods;The Cancer Genome Atlas;Therapeutic;Tissues;Training;treatment response;tumor;tumor DNA;tumor initiation;tumor progression;United States;Validation;Variant;Work;Writing

PROJECT_TITLE: Understanding Ancestral Contribution to Lung Adenocarcinoma

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alcoholism, Alcohol Use and Health;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Mental Health;Neurodegenerative;Neurosciences;Obesity;Physical Activity;Prevention;Rehabilitation;Substance Misuse;Women's Health Research

ORG_CITY: HERSHEY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: Project Narrative A growing population of obese, older adult breast cancer survivors face unique brain health challenges post-treatment, including cognitive impairments and anxiety symptoms. There is unanimous consensus among guidelines for cancer survivors that increasing physical activity and limiting alcohol consumption are key modifiable health behaviors to target for interventions; however, both the effects of light-intensity physical activity, and the unique interactions of physical activity and alcohol consumption on brain health, are unknown. The proposed study seeks to investigate the effects of a 15 week light-intensity physical activity intervention among obese, older adult breast cancer survivors, in comparison to usual care, on cognitive function and anxiety symptoms, and observe associated changes in alcohol consumption.

PI_NAMEs: GORDON, BRETT RYAN (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: Address;Advisory Committees;Aftercare;aged;Alcohol consumption;Alcohols;Alzheimer's disease risk;American;American Cancer Society;Anxiety;anxiety reduction;anxiety symptoms;arm;Biometry;brain health;Breast Cancer survivor;Breast Cancer Treatment;cancer diagnosis;Cancer Survivor;Carcinogens;Cessation of life;Clinical Trials;cognitive function;college;Consensus;Consumption;Data;Dementia;Diagnosis;Dose;drinking;Ecological momentary assessment;efficacy evaluation;efficacy trial;Exercise;exercise intervention;experience;Face;Fellowship;General Population;Grant;Guidelines;Health;Health behavior;health care settings;Human;Impaired cognition;improved;Individual;Inflammatory;International;Intervention;Knowledge;Late Effects;Learning;Light;light effects;light intensity;Malignant Breast Neoplasm;meetings;Mental Health;Mentors;modifiable behavior;mortality;multidisciplinary;novel;obese person;Obesity;Obesity Epidemic;older adult;Oncology;Outcome;Participant;Patient Self-Report;Physical activity;physical conditioning;Population Study;Postdoctoral Fellow;primary outcome;Process;psychological symptom;Randomized;randomized trial;Randomized, Controlled Trials;Recurrence;Reporting;Research;Research Personnel;response;Risk;Risk Reduction;Role;Series;Sports Medicine;Survival Rate;Survivors;Symptoms;Training;treatment as usual;treatment effect;United States;United States National Institutes of Health;vigorous intensity;Work

PROJECT_TITLE: Light Physical Activity for Brain Health in Older Adult Breast Cancer Survivors