NIH_SPENDING_CATS: Cancer;Clinical Research;Immunotherapy;Infectious Diseases;Precision Medicine;Sexually Transmitted Infections

PHR: PROJECT NARRATIVE There are no biomarker-selected, molecular targeted therapies for human papillomavirus (HPV) positive cancers. Aurora kinase inhibitors lead to cell death preferentially in HPV+ cancers and this death may sensitize HPV+ cancers to immunotherapy. To meet our long-term goal of improving cure rates for those with HPV+ cancer, we propose to test the hypothesis that Aurora kinase inhibition leads to cell death in HPV+ cancers due to Rb loss-induced genomic instability, to test the hypothesis that Aurora kinase inhibition will result in increased sensitivity to immune checkpoint therapy, and to identify biomarkers predicting response to the combination of immune checkpoint and Aurora kinase inhibition in patients with recurrent HPV+ cancers.

PI_NAMEs: JOHNSON, FAYE  (contact);SASTRY, JAGANNADHA K

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Address;Affect;Animal Model;anti-PD-1;antigen-specific T cells;Apoptosis;aurora B kinase;aurora kinase;aurora kinase A;biomarker driven;biomarker identification;biomarker selection;cancer cell;Cancer cell line;cancer infiltrating T cells;Cell Death;Cell Death Induction;Cell Line;Centrosome;Cessation of life;checkpoint therapy;chemotherapy;Chemotherapy and/or radiation;Chromosome Segregation;Clinical;clinical care;clinical practice;Clinical Trials;curative treatments;DNA Damage;Drug Combinations;Drug Kinetics;Drug Targeting;effective therapy;efficacy testing;experimental study;Genes;Genome Stability;Genomic Instability;Genomics;Goals;Growth;Head and Neck Squamous Cell Carcinoma;HPV negative;HPV positive;Human;Human Cell Line;Human Papillomavirus;immune checkpoint;immunogenic cell death;Immunologic Markers;Immunotherapy;improved;In Vitro;in vivo;Interferon Type I;kinase inhibitor;knock-down;knowledge translation;Lead;Lymphocyte Function;Malignant Neoplasms;Mediating;Mitosis;Mitotic;molecular targeted therapies;mouse model;Mus;neoantigens;oral HPV-positive head and neck cancers;overexpression;Pathway interactions;patient derived xenograft model;Patients;pembrolizumab;Pharmaceutical Preparations;Pharmacodynamics;Phosphotransferases;pre-clinical;predicting response;predictive marker;programmed cell death protein 1;Progression-Free Survivals;Protein-Serine-Threonine Kinases;Proteins;RB1 gene;Recurrence;Research;Resistance development;response;Role;Safety;senescence;Stimulator of Interferon Genes;Survival Rate;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;targeted treatment;Testing;Threonine;Tissues;Translating;treatment effect;Tumor Markers;tumor xenograft;Tumor-Infiltrating Lymphocytes

PROJECT_TITLE: Harnessing Aurora kinase inhibition‐induced cell death to enhance immunotherapy in HPV‐driven cancers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

ORG_CITY: LA JOLLA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PI_NAMEs: JAIN, SONIA  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Area;Biometry;Biostatistics Core;Caring;clinical investigation;clinical translation;Collaborations;cost effectiveness;Doctor of Philosophy;Grant;health equity promotion;HIV;Infection;infectious disease model;innovation;Institution;intervention cost;Leadership;member;Mentors;Methodology;Methods;Mission;Modeling;NIH Office of AIDS Research;novel;Pathogenesis;Persons;prevent;Price;Process;Publications;Reproducibility;Research;Research Design;Research Personnel;Research Priority;Resource Sharing;Risk;Science;Service provision;Services;Strategic Planning;Techniques;Technology;Training;transmission process;United States National Institutes of Health

PROJECT_TITLE: Core N: BAM


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: Newark

ORG_DEPT: PEDIATRICS

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Young adult cancer patients experience more distress and greater impairment in health-related quality of life compared with older patients, but current psychosocial care does not address their unique needs. The proposed randomized trial will evaluate a novel problem-solving skills training intervention designed to enhance patient problem-solving ability, reduce distress, and improve health-related quality of life. Results will advance clinical practice to reduce the cancer burden among this vulnerable group. ! !

PI_NAMEs: DEVINE, KATIE A (contact)

PROGRAM_OFFICER_NAME: SMITH, ASHLEY

PROJECT_TERMS: Address;Age;age group;Anxiety;anxiety symptoms;Awareness;Behavior;Behavior Therapy;Body Image;Cancer Burden;cancer diagnosis;Cancer Patient;cancer therapy;career;Caregivers;Characteristics;clinical care;clinical practice;Cognitive;coping;Coupled;course development;critical period;depressive symptoms;design;Development;Developmental Process;Diagnosis;Distress;Division of Cancer Control and Population Sciences;Education;Educational Intervention;Educational process of instructing;efficacy evaluation;Emotional;emotional distress;Evidence based intervention;experience;Family;Fertility;Financial Hardship;follow-up;Fostering;health related quality of life;high risk;higher education;Impairment;improved;Impulsivity;Individual;Intervention;intervention effect;Language;Learning;Life;Life Cycle Stages;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;Mediator;Mental Depression;mental health counseling;Mission;National Cancer Institute;negative affect;Newly Diagnosed;novel;older patient;Outcome;Parents;Participant;Patients;Pediatric Oncology;pediatric patients;personalized approach;Pilot Projects;Population;post intervention;prevent;Problem behavior;Problem Solving;problem solving therapy;Process;Productivity;Psychosocial Assessment and Care;psychosocial outcome;Quality of life;randomized trial;Randomized, Controlled Trials;reduce symptoms;Reporting;Research;Resources;sex;Site;skills;skills training;social;Social isolation;social stigma;Social support;Stress and Coping;stressor;Subgroup;Survivors;Testing;theories;therapy design;Time;Training Programs;treatment effect;Underserved Population;Vulnerable Populations;Work;young adult

PROJECT_TITLE: Bright IDEAS-Young Adults: Problem-Solving Skills Training to Reduce Distress among Young Adults with Cancer

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: FARMINGTON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PROJECT NARRATIVE This proposal seeks to study the mechanism underlying the function of three forkhead-box transcription factors, Foxp1, Foxp2, and Foxp4, in cerebellar development in mice. The proposed research will facilitate our understanding of how mutations of different FOXP proteins result in overlapping and distinct cognitive disorders found in humans.

PI_NAMEs: LI, JAMES Y.H (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Architecture;ATAC-seq;Ataxia;autism spectrum disorder;Behavioral;behavioral study;Bilateral;Binding;Biological Assay;Cell Differentiation process;Cells;Cerebellum;Characteristics;Chromatin;Code;Cognition Disorders;cognitive function;combinatorial;Cues;Data;Defect;Development;dimer;Disease;DNA Binding;Embryo;Excision;Family;FOXP1 gene;FOXP2 gene;Functional disorder;Genes;Genetic Transcription;Genome;Goals;Heterogeneity;Histology;Human;Image;In Vitro;Individual;insight;Intellectual functioning disability;Knowledge;language impairment;Link;Mental disorders;Molecular;Morphogenesis;Movement;multiple omics;Mus;Mutation;neural circuit;neurodevelopment;Neurodevelopmental Disorder;Neurons;Pathogenesis;Pathology;Phenotype;prevent;programs;prospective;Proteins;Psyche structure;Purkinje Cells;Research;RNA;Role;Schizophrenia;single cell ATAC-seq;single-cell RNA sequencing;Specific qualifier value;Speech Disorders;Subgroup;Testing;transcription factor;transcriptomics;Ultrasonics;vocalization

PROJECT_TITLE: Combinatorial function of Foxp1/2/4 in Purkinje cell diversification and cerebellar development

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR-M]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: STANFORD

ORG_DEPT: SURGERY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Vascular diseases such as coronary heart disease represent a pressing unmet medical need. One approach to identify new drug targets is to study DNA variants that influence risk for disease, but identifying the functions of these variants has been challenging. We will map the 3D structure of the human genome in blood vessels to identify new therapeutic targets for common vascular diseases.

PI_NAMEs: ENGREITZ, JESSE M (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: 3-Dimensional;Address;Affect;Alleles;Animals;Aorta;Atherosclerosis;Base Pairing;Binding Sites;Biological;Biology;Blood Vessels;causal variant;cell type;Cells;Chromosome Mapping;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;college;combinatorial;Computer Models;Coronary Arteriosclerosis;Coronary heart disease;CRISPR interference;CRISPR/Cas technology;Data;Disease;disorder risk;Distant;DNA;Educational process of instructing;Elements;Endothelin-1;Enhancers;Environment;experience;Frequencies;Future;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic;Genetic study;genetic variant;Genome;Genome engineering;Genome Mappings;genome resource;genome wide association study;genome-wide;Genomics;Hi-C;Human;human disease;Human Genetics;Human Genome;Hypertension;In Vitro;in vivo;innovation;invention;Link;Maps;Measures;Medical;Medicine;Methods;Modeling;Molecular;new therapeutic target;Outcome;prime editing;promoter;Protocols documentation;Regulation;Regulatory Element;Resolution;Resources;Risk;risk variant;Site;Susceptibility Gene;Testing;three dimensional structure;three-dimensional modeling;Tissues;trait;Universities;Untranslated RNA;Variant;Vascular Diseases;Work

PROJECT_TITLE: Mapping, modeling, and manipulating 3D contacts in vascular cells to connect risk variants to disease genes

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Burden of Illness;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prostate Cancer;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases

ORG_CITY: BOSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Though large racial disparities have been described in clinical prostate cancer outcomes, there has been limited investigation into racial disparities of patient-centered outcomes specifically in patients with advanced prostate cancer, the population experiencing the highest morbidity and mortality both from the cancer itself and its associated therapies. The proposed research aims to use data from approximately 1500 patients in the International Registry for Men with Advanced Prostate Cancer (IRONMAN) to quantify racial disparities in treatment patterns, patient experience with the health care system, and quality of life in patients with advanced prostate cancer in the United States and United Kingdom. This work will provide novel information on the spectrum of care received by patients with advanced prostate cancer and propose potential areas for intervention by health care providers towards decreasing racial disparities in prostate cancer mortality.

PI_NAMEs: RENCSOK, EMILY MAE (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Acceleration;access disparities;advanced prostate cancer;Affect;Area;Australia;black men;black patient;Black race;cancer care;Cancer Control;Cancer Patient;career;Caring;Clinical;Communication;Confidence Intervals;Data;Diagnosis;Disease;Disease Progression;Disparity;disparity reduction;Enrollment;Ensure;Equation;Equity;Ethnic Origin;European Organization for Research and Treatment of Cancer;experience;Failure;functional status;Goals;Guidelines;Health;Health Personnel;Health Services Accessibility;Healthcare Systems;Heterogeneity;high risk;improved;Incidence;Individual;International;Intervention;Investigation;Linear Regressions;Link;Logistic Regressions;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Medical Records;men;Modeling;Morbidity - disease rate;mortality;mortality risk;Newly Diagnosed;Not Hispanic or Latino;novel;novel therapeutics;Odds Ratio;Outcome;Outcome Measure;participant enrollment;Patient Care;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Pattern;Physicians;Population;Prospective cohort;prostate cancer survivors;Public Health;Quality of life;Questionnaires;Race;racial difference;racial disparity;Registries;Regression Analysis;Reporting;Research;study population;Surveys;survivorship;Symptoms;Time;Toxic effect;Training;Translating;treatment disparity;treatment pattern;United Kingdom;United States;uptake;Visual;Work

PROJECT_TITLE: Racial disparities in advanced prostate cancer care: An analysis of treatment patterns and patient experience

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Biotechnology;Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: BURTON, DENNIS R. (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Advisory Committees;Antigens;Area;B-cell receptor repertoire sequencing;Bar Codes;Biological Assay;Biometry;Caring;Cells;Cellular Assay;Cellular Immunology;Charge;Client;Collaborations;Communication;Communities;Computational Biology;computerized data processing;cost;Data;Data Analyses;data integrity;data pipeline;design;Development;DNA Sequencing Facility;Doctor of Philosophy;Ensure;Environment;Equipment;Experimental Designs;Feedback;Flow Cytometry;Funding;Gene Expression;Generations;Genetic Transcription;Genomics;Grant;Growth;health equity promotion;HIV;HIV Infections;improved;Individual;Infection;Infrastructure;innovation;instrumentation;Laboratories;Leadership;Maintenance;Manuscripts;meetings;member;Methodology;Methods;Mission;Modeling;Molecular;Molecular Immunology;Monitor;multiple omics;new technology;next generation;Online Systems;outreach;Phenotype;prevent;Price;Process;Productivity;Proteomics;Publications;quality assurance;Reagent;Recommendation;Reporting;Reproducibility;Research;Research Activity;Research Institute;Research Personnel;Research Priority;Resource Allocation;Resources;response;Services;single-cell RNA sequencing;Sorting;Specificity;Stimulus;Strategic Planning;Structure;Surveys;System;T-Lymphocyte;Technology;Training;transcriptomics;United States National Institutes of Health;Work

PROJECT_TITLE: Core P: Molecular and Cellular


ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative Ischemia-reperfusion injury causes early morbidity and mortality after lung transplantation for which there are currently no preventative therapies available. The objective of this proposal is to understand the cellular mechanisms responsible for lung ischemia-reperfusion injury and specifically how calcium uptake by TRPV4 channels contributes to ischemia-reperfusion injury and vascular inflammation. If successful, our studies will define TRPV4 as a novel and effective therapeutic target for the prevention of ischemia-reperfusion injury in lung transplant recipients.

PI_NAMEs: LAUBACH, VICTOR E (contact);SONKUSARE, SWAPNIL K.

PROGRAM_OFFICER_NAME: CHARYA, ANANTH VELUGALETI

PROJECT_TERMS: Acute;Acute Lung Injury;Affect;Alveolar;alveolar epithelium;Animals;antagonist;Arteries;Attenuated;Bone Marrow;Bronchiolitis Obliterans;Calcium;Calcium Channel;Cations;cell type;Cells;Chronic;Clinical Trials;clinically relevant;Coupled;Coupling;Data;driving force;Edema;Endothelial Cells;Endothelium;Epithelial Cells;Epithelium;Exposure to;extracellular;Family suidae;Fibroblasts;Functional disorder;graft dysfunction;Graft Rejection;Heart;Heart failure;Hypoxia;Immune;improved;In Vitro;in vivo;Inflammation;Inflammation Mediators;Inflammatory;inflammatory lung disease;inhibitor;insight;Kidney;Knockout Mice;Left;Leucocytic infiltrate;Lung;lung allograft;lung ischemia;lung microvascular endothelial cells;Lung Transplantation;Macrophage;Mediating;Mediator;Membrane;migration;Molecular;monolayer;Morbidity - disease rate;mortality;Mus;NADPH Oxidase;neutrophil;new therapeutic target;novel;Oxidative Stress;P2Y2 receptor;Patients;Pattern;Permeability;pharmacologic;Phosphorylation;prevent;Prevention;Preventive therapy;prophylactic;Proteins;Pulmonary artery structure;Pulmonary Edema;pulmonary function;Reactive Oxygen Species;receptor;Receptor Signaling;Reperfusion Injury;Reporting;Risk Factors;Role;Sepsis;Signal Transduction;Source;success;Sum;Testing;Therapeutic;therapeutic target;therapeutically effective;Translating;transplant model;Transplant Recipients;Transplantation;uptake;Vanilloid;Vascular Endothelial Cell;vascular inflammation;Vascular Permeabilities;Wild Type Mouse

PROJECT_TITLE: Role of TRPV4 channel signaling in lung ischemia-reperfusion injury

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Cost Effectiveness Research;Genetics;Human Genome

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Single-cell genome sequencing has proven to be a valuable tool to advance our understanding of tumor initiation, evolution, and resistance by providing the ability to catalogue the genetic subclones present within a tumor. However, current methodologies to profile single-cell genomes are either underpowered and expensive, or require designer reagents that are inaccessible to most research groups. Here we will develop technologies that produce improved data quantity and quality at a reduced cost that target the three major applications of single-cell genomics in cancer biology.

PI_NAMEs: ADEY, ANDREW  (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Acoustics;analysis pipeline;anti-cancer research;Area;Atlases;Bar Codes;Basic Science;Benchmarking;Biological Assay;Cancer Biology;Catalogs;Cell Line;Cell Nucleus;Cells;Chemistry;Chromium;Clinical;Collaborations;Communities;Complex;Computer software;cost;cost effective;Cost Effectiveness Analysis;Cost Savings;Custom;Data;density;design;Detection;DNA Sequence Rearrangement;Evolution;exome;exome sequencing;experimental study;gene panel;Genes;Genetic;Genome;genome sequencing;genomic profiles;Genomics;High-Throughput Nucleotide Sequencing;Human;Hybrids;improved;In Situ;in situ sequencing;indexing;instrument;instrumentation;interest;Libraries;Liquid substance;Metastatic breast cancer;Methodology;Methods;Microfluidics;Mus;nano;novel;Nucleosomes;Pancreatic Ductal Adenocarcinoma;Point Mutation;Population;Primary Brain Neoplasms;Property;Protocols documentation;Publishing;Reagent;Reproducibility;Research;Resistance;Sampling;single cell ATAC-seq;single cell genomics;single cell sequencing;Single Nucleotide Polymorphism;Solid Neoplasm;Structure;Technology;Therapeutic;therapy resistant;tool;tumor;tumor initiation;tumor progression;Validation;variant detection;whole genome

PROJECT_TITLE: Accessible high-throughput single-cell genome sequencing


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: LITTLE, SUSAN JANET (contact)

PROJECT_TERMS: Academia;Acquired Immunodeficiency Syndrome;Address;Adopted;Applications Grants;Area;Arizona;Award;California;career;Caring;Cities;Clinic;Clinical;Clinical Research;clinical translation;Collaborations;community academic partnership;community organizations;community partners;County;Creativeness;design;Development;Diagnosis;Direct Costs;dissemination science;Doctor of Philosophy;Environment;Epidemic;Epidemiology;flexibility;Focus Groups;Fostering;Funding;Future;Geography;Goals;Grant;Group Meetings;Health care facility;health equity promotion;HIV;HIV Infections;implementation science;Infection;interdisciplinary collaboration;interest;International;Intervention;knowledge base;Link;Location;meetings;member;National Institute of Mental Health;Nevada;next generation;Persons;Positioning Attribute;prevent;Process;Productivity;programs;Public Health;Publications;Recording of previous events;Research;Research Infrastructure;Research Institute;Research Personnel;Research Priority;Research Project Grants;response;Risk;Secure;Strategic Planning;success;Training;Training Support;Translational Research;United States;United States National Institutes of Health;working group

PROJECT_TITLE: SWG: EHE


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Biotechnology;Brain Disorders;Dementia;Fragile X Syndrome;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: NARRATIVE Fragile (NDD) that regulate single-cell investigate potential drug X-associate shares brain cellular-specific aggregation of proteins and ubiquitin, which have been shown to the degradation of proteins and inflammatory signaling in other NDDs. In this study, we use bulk and  high-resolution profiling of transcriptional alterations in post-mortem brain samples of FXTAS to the role of the ubiquitin pathway in FXTAS in comparison with other NDDs. This which study has the to identify critical mechanisms driving FXTAS can be exploited for biomarker discovery and target identification in FXTAS and more broadly in NDDs. Tremor Ataxia Syndrome (FXTAS) is a devastating late-onset neurodegenerative disorder

PI_NAMEs: LOZANO, REYMUNDO  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Academic achievement;Age;Alzheimer's Disease;Area;Ataxia;Automobile Driving;Autopsy;Basic Science;behavioral disinhibition;Biological;biomarker discovery;Brain;Brain region;brain tissue;C9ORF72;career;career development;Cell Nucleus;Cell Physiology;cell type;Cells;CGG repeat expansion;Chronic;Clinical;Clinical Research;Clinical Sciences;Clinical Services;Cluster Analysis;Collaborations;Complex;cytokine;Data Science;Data Set;Degradation Pathway;Dementia;Deposition;differential expression;Disease;effective therapy;Environment;Eukaryota;excitatory neuron;excitotoxicity;Faculty;FMR1 gene;Foundations;Fragile X Syndrome;FXTAS;Gene Expression;Gene Expression Profiling;Genetic;Genetic Diseases;Genetic Predisposition to Disease;Genetic study;genome sciences;Goals;human tissue;Hybrids;Immunohistochemistry;Impaired cognition;Individual;Inflammation;Inflammatory;insight;Instruction;interdisciplinary approach;Laboratories;Lateral;Lipids;Macrophage;Malignant Neoplasms;Mediating;medical schools;Mental Depression;Mentors;Mentorship;Messenger RNA;Metabolic;metabotropic glutamate receptor 5;Methods;Microglia;mitochondrial dysfunction;Molecular;Molecular Biology;Motor Cortex;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neurons;Neurosciences;neurotoxic;novel;Parkinson Disease;Parkinsonian Disorders;Pathogenesis;Pathologic;Pathologic Processes;Pathway Analysis;Pathway interactions;Peptides;Pharmaceutical Preparations;Phenotype;Physicians;polyglycine;polypeptide;Prefrontal Cortex;Process;programs;protein aggregation;protein degradation;Proteins;Proteome;proteostasis;Research;Research Personnel;Research Project Grants;Resolution;response;RNA;Role;Sampling;Scientist;Sclerosis;sex;Signal Transduction;single nucleus RNA-sequencing;skills;Somatic Cell;stem;System;therapeutic target;Time;Tissues;Training;Transcript;Transcription Alteration;transcriptome;transcriptome sequencing;Tremor;Tremor/Ataxia Syndrome;Ubiquitin;Ubiquitination;Western Blotting;Work

PROJECT_TITLE: FXTAS Key Molecular Pathways Converge with Other Neurodegenerative Disorders


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rare Diseases;Rural Health

ORG_CITY: SIOUX FALLS

ORG_NAME: SANFORD RESEARCH/USD

ORG_STATE: SD

PHR: PROJECT NARRATIVE The Great Plains Rare Disease Summit held at Sanford Research in Sioux Falls, SD will be a dual scientific and community conference. The first day of the summit is devoted to current updates from clinicians and rare disease researchers. The second day of the summit is tailored to patient advocacy groups, patients, and caregivers. The goal of the summit is to foster new relationships between research and advocacy, while building a robust community of rare disease advocates across both spectrums.

PI_NAMEs: WEIMER, JILL M (contact)

PROGRAM_OFFICER_NAME: BROOKS, PJ

PROJECT_TERMS: Address;Advocacy;Advocate;Affect;Air;American;Awareness;Back;burnout;Caregivers;Caring;Child;Clinical;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;community building;cost;Country;Data;Destinations;Disease;disease registry;Education;Environment;Event;Family;family burden;Fostering;genetic counselor;Goals;Great Plains;Health;Hearing;high standard;Home;Industry;industry partner;innovation;Knowledge;Medical;Medical Care Costs;meetings;member;Newly Diagnosed;Northern Plains;Participant;Patient advocacy;patient advocacy group;patient engagement;Patients;Persons;posters;programs;Public Health;Quality of life;rare condition;Rare Diseases;Recording of previous events;Registries;Research;Research Personnel;Resources;Rural;rural area;Schools;Scientist;Sioux Falls;support network;symposium;Technology;Time;Travel;Update;Work

PROJECT_TITLE: Great Plains Rare Disease Summit


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Estrogen;Genetics;Nanotechnology;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_CITY: CINCINNATI

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: This proposal is relevant to public health because it aims to understand the role of a key ER co- activator (MED1) and its crosstalk with Jab1 in HER2-driven breast tumorigenesis in the process of cancer growth, stem cell formation, metastasis and treatment resistance. Completion of the study is expected to not only broaden our knowledge base in these areas but will also provide potential new therapeutic agents for the treatment of human breast cancer. Thus, the proposed research is relevant to the mission of NIH to conduct research for the prevention and cure of human diseases.

PI_NAMEs: ZHANG, XIAOTING  (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: 17q12;Area;Biological Assay;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Patient;Breast Cancer Treatment;breast tumorigenesis;Cancer Cell Growth;cancer stem cell;cancer therapy;Cause of Death;Chromosomes;Clinical;COPS5 gene;CRISPR/Cas technology;Cullin Proteins;Data;Disease Progression;efficacy testing;ERBB2 gene;ESR1 gene;Estrogen Antagonists;Estrogen Receptors;Funding;Future;Gene Expression;Gene Expression Profile;Gene Expression Profiling;gene function;Genes;Genetic Transcription;Goals;Growth;Human;human disease;In Vitro;in vivo;knock-down;Knock-in;Knowledge;knowledge base;Malignant Breast Neoplasm;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Mediator;Mission;Modeling;Molecular;mouse model;Mutagenesis;mutant;Names;nanoparticle;Nanotechnology;Neoplasm Metastasis;novel strategies;novel therapeutics;Outcome;overexpression;Pathway interactions;Patients;Play;PPARBP gene;Prevention Research;Process;Proteins;Public Health;Reagent;Regimen;Regulation;Reporter;Research;Resistance;RNA;Role;Site;small hairpin RNA;Stains;stem cells;targeted treatment;Testing;Therapeutic Agents;therapeutic evaluation;therapy resistant;thyroid hormone receptor associated protein 220;Tissue Microarray;Toxic effect;Transcription Coactivator;transcriptome sequencing;tumorigenesis;Ubiquitination;United States National Institutes of Health;Validation;Western Blotting;Women's mortality;Xenograft procedure

PROJECT_TITLE: Role of MED1 in HER2-mediated tumorigenesis

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Nanotechnology;Pediatric;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Wound Healing and Care

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: The proposed research is relevant to public health as cleft palate is the most common craniofacial congenital anomaly and cleft palate repair is associated with wound healing complications in up to 60% of patients, resulting in an oronasal fistula (ONF). ONF occurrence is associated with poor feeding and speech and typically requires multiple additional surgeries to repair. This proposal is relevant to the NIH's mission to develop innovative therapies and we propose an immunomodulatory strategy to improve oral cavity wound healing, reducing ONF formation, by attracting pro-regenerative monocytes and macrophages using FTY720 containing nanofiber delivery.

PI_NAMEs: GOUDY, STEVEN L (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: Affect;Agonist;Allografting;Area;Bacteria;Biocompatible Materials;Blood;Blood Vessels;cell motility;Cells;Child;Chronic;Cleft Palate;Clinical Trials;congenital anomaly;cost;craniofacial;Craniofacial Abnormalities;cytokine;Data;Dermal;Development;dimension reduction;Drug Delivery Systems;Drug Targeting;Eating;efficacy evaluation;Engineering;Environment;FDA approved;feeding;Fistula;Future;Gene Expression;Genes;Genetic Models;Goals;healing;HIV;Human;Immune;Immune response;immunomodulatory strategy;immunomodulatory therapies;immunoregulation;Implant;improved;infection risk;Inflammatory;Inflammatory Response;injured;Injury;innovation;Innovative Therapy;Live Birth;Macrophage;migration;Mission;monocyte;Morbidity - disease rate;mouse genetics;mouse model;Mucous Membrane;Multiple Sclerosis;multiplex assay;Mus;Muscle;nanofiber;Nanofiber Scaffold;novel;Operative Surgical Procedures;Oral;Oral cavity;Palate;palate repair;Paper;Pathway Analysis;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phenocopy;Population;prevent;Prions;Process;Production;progenitor;programs;Proliferating;Public Health;Publishing;recruit;regenerative;regenerative therapy;repair model;repaired;Research;response;response to injury;Risk;Role;Rotation;scaffold;Science;Signal Transduction;single-cell RNA sequencing;Skin;Skin wound healing;small molecule;soft tissue;Soft Tissue Injuries;Speech;Sphingosine;Sphingosine-1-Phosphate Receptor;Surgeon;System;targeted treatment;Testing;therapeutic target;therapy outcome;Tissue Donors;Tissue Engineering;tissue regeneration;Tongue;tool;transcriptome sequencing;transmission process;Trauma;treatment optimization;United States National Institutes of Health;wound bed;wound healing

PROJECT_TITLE: An immunomodulatory approach to improve oral cavity wound healing

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Acute lower respiratory tract infection from Klebsiella pneumoniae is a common problem affecting hospitalized patients with higher mortality in the critically ill. The long term objective of this proposal is to elucidate how host metabolism drives host defense and resilience against this bacteria within the lung. Understanding host- pathogen interactions will lead to rational, targeted therapy design to improve clinical outcomes of Klebsiella pneumoniae infections in vulnerable patient populations.

PI_NAMEs: SUBER, TOMEKA L (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Aconitic Acid;Acute;Acute Lung Injury;Address;Affect;alveolar epithelium;Alveolar Macrophages;Antibiotic Resistance;Bacteria;Basic Science;biological adaptation to stress;Biology;Bleomycin;Bone Marrow;Carboxy-Lyases;career development;Cell Death;cell injury;Cell Line;Cell Survival;Cells;Cellular biology;Cellular Stress;Chimera organism;Citric Acid Cycle;Clinical;conditional knockout;Critical Care;Critical Illness;cytokine;Death Rate;defense response;Development Plans;effective therapy;Elderly;endoplasmic reticulum stress;Enzymes;Epithelial Cells;epithelial injury;Equilibrium;Exhibits;Experimental Models;Exposure to;Fibroblasts;Focal Infection;Foundations;Goals;Gram-Negative Bacteria;Hospitalization;Host Defense;Host Defense Mechanism;Human;Immune;Immunocompromised Host;Immunophenotyping;improved;improved outcome;In Vitro;in vivo;in vivo Model;Infection;Inflammation;Inflammatory Response;Injury;Intensive Care Units;interest;Interferon Type I;K-Series Research Career Programs;Klebsiella pneumoniae;knock-down;Knockout Mice;Knowledge;Lipopolysaccharides;Lower Respiratory Tract Infection;Lung;Lung infections;Macrophage;Mediator;Medicine;Mentors;Mentorship;Metabolic;Metabolism;metabolomics;Mitochondria;Modeling;monocyte;mortality;mouse model;Multi-Drug Resistance;multidisciplinary;Mus;Myelogenous;Myeloid Cells;Nosocomial pneumonia;novel;Outcome;pathogen;Pathway interactions;patient population;Patients;Physicians;Pneumonia;pneumonia model;Population;Predisposition;Prevalence;Production;programs;Proliferating;Proteins;Publishing;Pulmonary Fibrosis;Regulation;Research;Research Personnel;resilience;resistant Klebsiella pneumoniae;Resolution;response;Role;Scientist;Sepsis;Single Nucleotide Polymorphism;skills;Slice;Small Interfering RNA;Source;Specificity;stressor;Structure of parenchyma of lung;success;Syndrome;Systemic disease;targeted treatment;Techniques;Testing;therapy design;therapy development;tissue injury;Tissues;tool;Training;transcriptomics;Translational Research;Work;wound healing

PROJECT_TITLE: Intrapulmonary itaconate as a host-protective metabolite during ER Stress and Klebsiella pneumoniae infection

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Prevention;Women's Health Research

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Project Narrative Breast cancer remains the second leading cause of cancer death and for many survivors, contributes to significant disease and treatment related physical and psychosocial side effects, medical costs and reduced quality of life. As such, primary prevention of breast cancer in women at increased risk with an agent that is safe and well tolerated is highly desirable. Non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin, demonstrate anti-cancer activity in breast cancer models, with observational evidence that supports lower odds of breast cancer among regular users. We have found that the NSAID sulindac, after one year of use, significantly reduces breast density, an established risk factor for breast cancer, and changes the structure of collagen in breast tissue in women taking aromatase inhibitors for the treatment of their breast cancer when compared to a control group. We propose a clinical trial using magnetic resonance imaging (MRI) and tissue biopsy to test the effect of sulindac on breast density and breast tissue in women at increased risk of breast cancer and we will compare its activity on breast density and breast tissue to aspirin and a control group. Ours is the first evidence of an effect of an NSAID on breast density, an established risk factor for breast cancer. Furthering our understanding of this activity is important to advancing the beneficial actions of NSAIDs observed in epidemiologic and animal studies to primary breast cancer chemoprevention in patients at increased risk of developing breast cancer.

PI_NAMEs: STOPECK, ALISON T.;THOMPSON, PATRICIA ANN (contact)

PROGRAM_OFFICER_NAME: SAUTER, EDWARD RICHARD

PROJECT_TERMS: Adipose tissue;Animal Model;Animals;anti-cancer;Anti-Inflammatory Agents;anticancer activity;antitumor effect;arm;Aromatase;Aromatase Inhibition;Aromatase Inhibitors;Arthritis;Aspirin;Biological Markers;Biopsy;Breast;Breast biopsy;Breast Cancer Model;Breast Cancer Prevention;Breast Cancer Prevention Trial;Breast Cancer Risk Factor;breast density;breast imaging;cancer care;cancer chemoprevention;Cancer Etiology;cancer recurrence;Carcinoma;Cd68;Cell model;Cessation of life;Chemopreventive Agent;Clinical Trials;Collagen;comparison control;Contralateral Breast;Control Groups;Core Biopsy;cyclooxygenase 2;Data;Dinoprostone;Disease;Dose;Drug usage;Early Diagnosis;Early treatment;epidemiologic data;Epidemiology;Estradiol;Estrogen receptor positive;Familial Adenomatous Polyposis Syndrome;Funding;Generations;Grant;group intervention;High Risk Woman;Image;Individual;inhibitor therapy;innovation;interest;Intervention;Investigation;Iron;Lasers;Macrophage;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammography;Mass Spectrum Analysis;Measures;Mediating;Medical Care Costs;Methods;Microscopy;Minor;Morbidity - disease rate;Non-Steroidal Anti-Inflammatory Agents;novel;open label;Pain;Patient Agents;Patients;Pharmaceutical Preparations;Postmenopause;pre-clinical;Pre-Clinical Model;prevent;Prevention;primary endpoint;Primary Prevention;Prodrugs;Prostaglandin Inhibition;Prostaglandin-Endoperoxide Synthase;psychosocial;Quality of life;Randomized;Research Priority;Risk;second harmonic;side effect;Slide;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Structure;Sulindac;Survivors;Testing;three-arm study;three-arm trial;Tissues;treatment arm;trial comparing;tumor;Woman;Women's mortality

PROJECT_TITLE: Three-Arm randomized trial comparing the effect of aspirin, sulindac or no treatment control on breast density in patients with elevated breast cancer risk

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


NIH_SPENDING_CATS: Cardiovascular;Neurosciences;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

PHR: PROJECT NARRATIVE – RELEVANCE TO PUBLIC HEALTH Spinal cord injury (SCI) affects 1.3 million Americans. The proposed experiments in this application are relevant to public health because they seek to identify therapeutic strategies to either prevent or decrease the severity of multiple, potentially life-threatening effects of sympathetic dysregulation after SCI.

PI_NAMEs: TOM, VERONICA JEAN (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Affect;American;Animals;antagonist;Autonomic Dysfunction;Autonomic Dysreflexia;Axon;Bacterial Pneumonia;Bladder;Blood;brain control;Brain Stem;Cardiovascular Diseases;cardiovascular infection;Cardiovascular Physiology;Cardiovascular system;Chest;Chronic;clinically relevant;Collaborations;Contusions;cytokine;Disparate;efficacy evaluation;Event;experimental study;Fiber;Functional disorder;hemodynamics;Hyperreflexia;Hypertension;immune function;Immune system;Immune System Diseases;Immunity;immunodeficiency;Immunosuppression;improved;Individual;Infection;injured;Injury;Interruption;Life;Mediating;Modeling;Morbidity - disease rate;mortality;nerve supply;Neurons;Organ;Output;Peptides;Persons;Physiological;Play;Predisposition;prevent;Prophylactic treatment;Public Health;receptor;Recovery of Function;Regulation;response;Rodent;Role;Secondary to;Serotonin;Severities;Signal Transduction;Silver;Spinal;Spinal Cord;Spinal cord injury;Spleen;Sympathetic Nervous System;System;Testing;Therapeutic;Tissues;TNF gene;Transplantation;tumor necrosis factor-alpha inhibitor

PROJECT_TITLE: Multipronged approach to diminish sympathetic hyperreflexia and ensuing cardiovascular and immune dysfunction after spinal cord injury


NIH_SPENDING_CATS: Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Delineating the functionality and pharmacology of specific supraspinal pathways involved in pain modulation is of critical importance if we are to understand neural dysfunction that contributes to chronic pain. The goal of this project is to define neural mechanisms through which a common lipid signaling pathway drives antinociception by altering the excitability of specific supraspinal pathways sensitized by chronic pain. Findings of this project have promising potential for uncovering preclinical and clinical drug targets within sensory-discriminative and affective supraspinal circuits that could lead to novel approaches exploiting lipid signaling pathways for treating chronic pain.

PI_NAMEs: SHEETS, PATRICK L (contact);TAYLOR, BRADLEY K.

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Absence of pain sensation;Acute Pain;Affective;Agonist;Amygdaloid structure;Analgesics;antagonist;antinociception;Attenuated;attenuation;Behavior;Behavioral;Brain;Cell Nucleus;chronic pain;chronic pain management;Clinical;Clinical Treatment;conditioned place preference;Corticotropin-Releasing Hormone;Coupled;Data;designer receptors exclusively activated by designer drugs;Development;Dimensions;Drug Targeting;Electrophysiology (science);Emotional;FDA approved;Genes;Genetic;Goals;GTP-Binding Proteins;Hypersensitivity;immunoregulation;Induced Neurons;Inflammation;Inflammatory;inflammatory pain;Infusion procedures;Injections;Injury;Knowledge;Label;Link;Lipids;Literature;Lysophospholipids;Mechanics;Mediating;Microinjections;Modeling;Molecular;Molecular Profiling;mouse model;multiple sclerosis treatment;Mus;nerve injury;neurochemistry;neuromechanism;Neuronal Dysfunction;Neurons;neurophysiology;novel;novel strategies;optogenetics;Pain;pain behavior;pain model;pain reduction;painful neuropathy;Pathway interactions;Peripheral;Pharmaceutical Preparations;pharmacologic;Pharmacology;Population;pre-clinical;protein kinase C-delta;receptor;Receptor Activation;Reporting;Role;Sensory;Signal Pathway;Signal Transduction;Slice;Somatostatin;Sphingolipids;sphingosine 1-phosphate;Sphingosine-1-Phosphate Receptor;Synapses;Tactile;Testing;tissue injury;Transgenic Mice;Transgenic Organisms;Translating

PROJECT_TITLE: Lipid signaling in supraspinal pain pathways

STUDY_SECTION: SPS

STUDY_SECTION_NAME: Somatosensory and Pain Systems Study Section[SPS]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative For 38 years, Children’s Hospital Oakland Research Institute has hosted a program for underrepresented minorities to confront the disparities of representation for students of color and economic disadvantage within science employment and academic programs. In this request for continued funding, we propose an updated curriculum called STIMULUS (Science & Technology IMmersion for Underrepresented Learners in the US) in order to grow the program and be responsive to the changing needs of modern student. The curriculum has many additions, including new collaborations with the UCB Department of Bioengineering, more comprehensive training workshops, expanded recruiting from regional pipeline programs and historically black colleges, formalized program for near-peer mentoring, case-based approach for bioethics education, and enhanced alumni tracking and evaluation.

PI_NAMEs: FUNG, ELLEN B (contact);TREADWELL, MARSHA J

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Abbreviations;academic program;Address;Area;arm;Asian;Asian population;Basic Science;Bioethics;Biomedical Engineering;Biomedical Research;Black race;California;career;case-based;Clinical Research;cohort;Collaborations;Color;Communities;Country;Cultural Diversity;Disparity;economic disparity;Education;Education Projects;Educational Curriculum;Educational workshop;Employment;Engineering;engineering design;Enrollment;Equilibrium;Ethics;ethnic diversity;Evaluation;experience;falls;Foundations;Funding;gender diversity;Goals;Health Professional;Historically Black Colleges and Universities;Immersion;improved;Infrastructure;innovation;Institutional Review Boards;interest;Latino;Mathematics;medical schools;Mentors;Mission;Modernization;National Heart, Lung, and Blood Institute;Native Americans;Occupations;Pediatric Hospitals;peer coaching;Policies;professional students;programs;racial diversity;recruit;Research;Research Design;Research Institute;Research Training;responsible research conduct;San Francisco;Schools;Science;Secure;skill acquisition;statistics;Statutes and Laws;STEM career;stem cells;STEM program;Structure;Student Selections;Students;success;summer student;Technology;Training;Training Programs;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;Update

PROJECT_TITLE: STIMULUS - Science & Technology Immersion for Underrepresentd Learners in the U.S.


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Opioids;Substance Misuse

PI_NAMEs: MEUCCI, OLIMPIA  (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: 3-Dimensional;Adjuvant Therapy;Adult;Affect;Animal Model;antiretroviral therapy;Architecture;Award;Back;behavioral study;Brain;Cells;Central Nervous System;chemokine;chemokine receptor;Chronic;Clinical;Clinical Management;Cognition;Cognitive;Cognitive deficits;Collaborations;Complement;Complex;Coupled;CXCR4 gene;CXCR4 Receptors;Dendritic Spines;Development;Disease;Electrophysiology (science);Environment;Event;flexibility;Functional disorder;Future;hippocampal pyramidal neuron;HIV;HIV-associated neurocognitive disorder;Human;Image;Impaired cognition;improved;in vivo;Individual;Inflammation Mediators;inhibitory neuron;interest;Interneurons;knock-down;Knowledge;Ligands;Link;Measures;Medial;Mediating;Methods;Modeling;Modernization;Molecular;Monitor;Morphine;multi-electrode arrays;Network-based;neuroAIDS;neurocognitive test;Neuroglia;Neurologic Symptoms;Neurons;neuroprotection;neuropsychiatry;Neurosurgeon;Neurotoxins;new therapeutic target;novel strategies;Opioid;Opioid agonist;Opioid Receptor;opioid use;opioid user;optogenetics;Outcome;Pathology;Pathway interactions;Persons;Population;Prefrontal Cortex;preservation;Process;Prognosis;Proteins;Rattus;receptor;recruit;Regulation;Rodent;Role;Signal Transduction;Site;Slice;Somatostatin;Stimulus;Stromal Cell-Derived Factor 1;Substance abuse problem;Substance Use Disorder;Synapses;Synaptic plasticity;System;Techniques;Testing;Therapeutic;therapeutic evaluation;Tissues;Transgenic Model;Transgenic Organisms;translational applications;two photon microscopy;validation studies;Vertebral column;Viral Proteins;Virus Diseases;Work

PROJECT_TITLE: Role of chemokines in neuronal function and survival


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Immunization;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE This competive renewal focuses on characterization of residual CLL cells and immune function of the microenvironment after prolonged therapy with an irreversible Bruton’s tyrosine Kinase inhibitor (BTKi), either ibrutinib and acalabrutinib. Additionally, this project seeks to target these residual cells for elimination clinically using novel immune based therapies such as VAY-736 to facilitate discontinuation strategies of BTKi with significant economic and survivorship benefit to patients with CLL.

PI_NAMEs: ROGERS, KERRY ANNE;WOYACH, JENNIFER A. (contact)

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: adult leukemia;Agammaglobulinaemia tyrosine kinase;Antibodies;Antibody Therapy;antibody-dependent cell cytotoxicity;Antibody-Dependent Enhancement;BCL3 gene;Behavior;Biochemical;Biological Factors;Blocking Antibodies;Cell Physiology;Cells;Characteristics;Chronic Lymphocytic Leukemia;chronic lymphocytic leukemia cell;Clinical;clinical development;Clinical Trials;Collaborations;Combined Modality Therapy;curative treatments;Data;design;Disease;Disease remission;Disease Resistance;Economics;Effector Cell;Engineering;Epigenetic Process;follow-up;Frequencies;Future;Gene Amplification;Genetic Transcription;Genomics;Goals;Grant;Heterogeneity;humanized antibody;Immune;immune function;Immuno-Chemotherapy;immunological status;Immunologics;Immunotherapy;improved;In complete remission;inhibitor therapy;Investigation;Journals;leukemia;Lymphocytosis;Malignant lymphoid neoplasm;Mediating;member;Methodology;Morbidity - disease rate;mouse model;Mutation;Natural Killer Cells;neoplastic cell;novel;Nuclear Protein;Paper;Pathway interactions;patient response;patient subsets;Patients;Pharmaceutical Preparations;Pharmacodynamics;Phase;Phase I Clinical Trials;Phase Ib Clinical Trial;Population;pre-clinical;preclinical development;primary endpoint;profiles in patients;Property;protein expression;Publications;Publishing;receptor;Recovery;Reporting;Residual Neoplasm;Residual state;Resistance;Retreatment;side effect;Signal Pathway;Signal Transduction;survivorship;Symptoms;targeted treatment;Techniques;Testing;therapy duration;Time;Toxic effect;Transcript;treatment duration;treatment strategy;tumor;Tyrosine Kinase Inhibitor;United States;Up-Regulation;Work

PROJECT_TITLE: Targeted Therapies for Lymphoid Malignancies

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer;Orphan Drug;Precision Medicine;Rare Diseases

ORG_DEPT: PATHOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: NARRATIVE KRAS-driven non-small cell lung cancer (NSCLC) remains one of the most aggressive and lethal solid tumors, therapeutic options and outcomes for NSCLC have remained virtually unchanged over the past thirty years. Using novel CRISPR/Cas9-based genome-engineering technologies we have established a unique and rapid research program to functionally characterize lung cancer mutations and identify genotype-specific metabolic vulnerabilities that can lead to novel therapeutic approaches in KRAS-driven lung cancer.

PI_NAMEs: PAPAGIANNAKOPOULOS, THALES  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Acceleration;Address;Antioxidants;Biochemical;Biochemical Pathway;cancer cell;Cancer Patient;cancer subtypes;cancer type;Cell Line;Cells;Clinical;Clinical Oncology;Clinical Trials;CRISPR/Cas technology;Dependence;early phase clinical trial;Gene Expression Profile;Genes;Genetic;genetic approach;Genetic Screening;Genetic Transcription;Genetically Engineered Mouse;Genome engineering;Genotype;Glucose;Glutaminase;Glutamine;Goals;Homeostasis;Human;In Vitro;in vivo;inhibitor;K-ras mouse model;KRAS2 gene;loss of function mutation;Lung Adenocarcinoma;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Metabolic;Metabolic Pathway;Metabolism;Modeling;Molecular;Mus;mutant;Mutation;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;Nutrient;Oncoproteins;Outcome;Oxidative Stress Pathway;Pathway interactions;patient derived xenograft model;patient stratification;pharmacologic;Pre-Clinical Model;precision medicine;preclinical study;Production;programs;Property;Reactive Oxygen Species;Research;Resistance;Resistance development;resistance mechanism;response;Role;Solid Neoplasm;Stratification;targeted treatment;Technology;Therapeutic;treatment responders;tumor;virtual

PROJECT_TITLE: Identifying metabolic dependencies in genetic subtypes of KRAS-driven lung cancer

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emergency Care;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE  This real world efficacy study (NIH stage 3) will determine the benefit of social needs (e.g., for housing, food, transportation) screening, community-based service referrals, and telephonic follow-up as a scalable, sustainable strategy for preventing COVID-19 transmission, and for addressing the secondary health effects of the social, behavioral, and economic impact of the COVID-19 pandemic. Results of this study will provide much needed information regarding whether social needs screening and community service referrals improves health outcomes of vulnerable and socioeconomically disadvantaged populations, an NIH-designated health disparity population, and whether intensive follow-up and collaborative goal-setting helps overcome barriers to community service use by patients seen in the emergency department and seeking COVID testing at community-based and mobile clinic locations.

PI_NAMEs: WALLACE, ANDREA SCHNEIDER (contact)

PROGRAM_OFFICER_NAME: SEAY, JULIA SUSAN

PROJECT_TERMS: 2019-nCoV;Accident and Emergency department;Address;Age;Anxiety;Behavior;Behavioral;Characteristics;Charge;Clinic;Clinical;Communities;community based service;community partners;Community Services;Computer software;coping;cost;Country;COVID-19;COVID-19 health disparity;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;COVID-19 prevention;COVID-19 susceptibility;COVID-19 testing;Data;data exchange;Disparity;Drops;economic impact;Economically Deprived Population;Economics;effectiveness evaluation;efficacy study;Emergency Care;Emergency Department patient;Emergency department visit;Emotional;Environment;Ethnic Origin;experience;follow-up;Food;Gender;Goals;Health;health care availability;health disparity;health disparity populations;health information technology;health service use;Health Services Accessibility;Health Status;Health system;Hospitalization;Housing;improved;Individual;Information Specialists;Intervention;Interview;Language;Location;Measures;meetings;Mental Depression;Methods;Modeling;Motivation;Outcome;outreach;patient engagement;patient screening;Patients;Personal Satisfaction;Play;Policies;Population;post-COVID-19;pragmatic trial;Preventive;Process;programs;Protocols documentation;Psyche structure;Public Health;Quarantine;Race;Randomized;referral services;Reporting;Research;Resources;response;Role;Rural;Sampling;SARS-CoV-2 transmission;screening;screening services;service providers;Services;Site;social;social communication;social determinants;Social Distance;socioeconomic disadvantage;System;Technology;Telephone;Testing;transmission process;Transportation;treatment arm;treatment as usual;underserved community;Underserved Population;United States National Institutes of Health;Vaccines

PROJECT_TITLE: Intensifying Community Referrals for Health: The SINCERE Intervention to Address COVID-19 Health Disparities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-W(56)R]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: Research narrative Neuroendocrine cells in adrenal glands secrete adrenalin in response to stress, increasing the rate of blood circulation, breathing, and carbohydrate metabolism, preparing muscles to exert. However, extracellular matrix proteins are constantly secreted from fibroblasts to embed cells within tissues and protect them from mechanical damage. Our work will elucidate basic mechanisms controlling secretion to help understand pathologies such as psychiatric disorders or cancer.

PI_NAMEs: VON BLUME, JULIA  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Adrenal Glands;Biochemical Process;Blood Circulation;Breathing;carbohydrate metabolism;Cell Culture Techniques;Cell surface;cell type;Cells;Cellular biology;Chromogranins;Client;Cytoplasmic Granules;Deposition;Destinations;extracellular;Extracellular Matrix;Extracellular Matrix Proteins;Fibroblasts;Goals;Health;Human;IGF Type 2 Receptor;In Vitro;Liquid substance;macromolecule;Malignant Neoplasms;Mechanics;Membrane;membrane model;Mental disorders;Modeling;Modernization;Molecular;Muscle;Neuroendocrine Cell;novel;Organism;Pathology;Phase;Physical condensation;Play;Process;protein distribution;Protein Secretion;Proteins;receptor;reconstitution;Research;response;Role;secretory protein;segregation;Signal Transduction;Signaling Molecule;Skin;Sorting;Stimulus;Stress;System;Tissues;trans-Golgi Network;Work

PROJECT_TITLE: Mechanism of secretory cargo sorting at the trans-Golgi Network (TGN)


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: WISTAR INSTITUTE

PHR: Project Narrative The proposed research is of high relevance to Public Health, because it aims at understanding and controlling Notch1-driven leukemogenesis and discovering potential new target to guide the personalized treatment of a disease of unmet need. The successful completion of the proposed project will elucidate a new ‘molecular rheostat’ that calibrate Notch signaling activation and open the way for targeting the endo-lysosomal pathway in T-ALL.

PI_NAMEs: LIANG, CHENGYU  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Acute T Cell Leukemia;acute T-cell lymphoblastic leukemia cell;Address;Adult;Affect;Animal Model;Autophagocytosis;Biochemistry;Biological Assay;Bone Marrow;Calibration;Cell Line;Cell Nucleus;Cell Physiology;Cells;chemotherapy;Child;Clinic;Collaborations;Complex;cost;CRISPR/Cas technology;cytotoxicity;Data;Development;Disease;Disease remission;Disease Reservoirs;dosage;Drosophila genus;experimental study;Frequencies;Gene Expression;gene function;Generations;Genes;Genetic;genome editing;Goals;Half-Life;Hematologic Neoplasms;high resolution imaging;Homeostasis;Human;Immunocompromised Host;improved;in vitro Assay;in vivo;innovation;insight;Investigation;lentivirally transduced;leukemia;leukemia initiating cell;leukemia treatment;Leukemic Cell;leukemogenesis;Maintenance;Malignant - descriptor;Malignant lymphoid neoplasm;Malignant Neoplasms;Mediating;Mediator;Membrane;Modeling;Molecular;Molecular Biology;mouse model;multidisciplinary;Mus;Mutation;notch protein;novel;novel therapeutic intervention;novel therapeutics;Oncogene Activation;Oncogenes;Oncogenic;Pathogenesis;Pathologist;Pathology;Pathway interactions;Patients;personalized medicine;Physiological;Process;Proteolytic Processing;Public Health;Recurrent disease;Refractory;Regulation;Relapse;Research;Resistance;response;restoration;Role;Sampling;self-renewal;Shapes;side effect;Signal Transduction;single molecule;small molecule inhibitor;stem cell self renewal;stem cells;stemness;T-Cell and NK-Cell Neoplasm;T-Cell Leukemia;T-Cell Proliferation;T-Lymphocyte;targeted treatment;Testing;therapy resistant;Titrations;Transgenic Mice;Translations;Transplantation;Tumor Suppressor Genes;Tumor Suppressor Proteins;ubiquitin ligase;Ubiquitination;UV induced;UV radiation-resistance associated gene;Work

PROJECT_TITLE: New control of oncogene activation in T-cell leukemia

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ORG_CITY: Newark

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: This proposed study aims to understand the role and mechanism of gain-of-function mutant p53 in colorectal tumorigenesis. We will test the hypothesis that mutant p53 drives fatty acid synthesis as a critical gain-of-function mechanism to promote colorectal tumorigenesis, which can be targeted for therapy in colorectal cancers carrying mutant p53. We expect that the results from this study will deepen our understanding of mechanism of mutant p53 in tumorigenesis, and provide the rationale and base for the development of new therapeutic targets and strategies for cancers carrying mutant p53.

PI_NAMEs: FENG, ZHAOHUI ;HU, WENWEI  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: ApcMin/+ mice;Automobile Driving;base;Biological;cancer cell;cancer therapy;chemical carcinogen;chemotherapy;Clinical;colon tumorigenesis;Colorectal Cancer;colorectal cancer progression;colorectal cancer treatment;Colorectal Neoplasms;conditional knockout;Development;Enzymes;Event;FASN gene;Fatty Acids;gain of function;Goals;Homeostasis;Human;Knock-in Mouse;Lipids;liquid chromatography mass spectrometry;Malignant Neoplasms;Mediating;Metabolic;Metabolism;metabolomics;Modeling;mouse model;Mus;mutant;Mutate;Mutation;new therapeutic target;novel;Nude Mice;Oncogenic;phosphoproteomics;Phosphorylation;Play;Prevention;Proteomics;Regulation;Resolution;Role;Sampling;small hairpin RNA;small molecule inhibitor;targeted cancer therapy;targeted treatment;Testing;Therapeutic;TP53 gene;transcriptome sequencing;tumor;tumor progression;Tumor Suppression;tumorigenesis;Ubiquitination;Work

PROJECT_TITLE: Gain-of-function mutant p53 and metabolic reprogramming in colorectal cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-J(02)M]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Heart Disease;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Hundreds of thousands of adult patients undergo cardiac surgery every year in the United States, each of whom has a significant risk of reintubation after surgery. A better understanding of interventions that can effectively decrease the reintubation rate could help decrease short- and long-term mortality, cost, and hospital length of stay. Therefore, we propose the “Reducing ReIntubation Risk in High-Risk Cardiac Surgery Patients with High-Flow Nasal Cannula” (I-CAN) Study, to assess whether this simple, relatively non-invasive technique can help decrease postoperative reintubation rates.

PI_NAMEs: FREUNDLICH, ROBERT EDWARD (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Academic Medical Centers;Address;Admission activity;Adult;Age;Anesthesiology;Area;Beds;Biometry;Board Certification;Calibration;Cannulas;Cardiac Surgery procedures;Cardiovascular system;career;career development;Certification;Clinical and Translational Science Awards;clinical care;Clinical Informatics;Clinical Research;Clinical Trials;Clinical Trials Design;cohort;comorbidity;comparative effectiveness trial;Complex;Coronary Artery Bypass;cost;Critical Care;Data;data tools;data warehouse;Decision Making;Development;Development Plans;effective intervention;Electronic Health Record;Environment;Event;experience;Fellowship;Fostering;Foundations;Freedom;Funding;Future;Goals;Grant;Healthcare Systems;high risk;Hour;Hypoxia;improved;Informatics;informatics tool;Intensive Care Units;Interdisciplinary Study;Intervention;Intubation;Leadership;leadership development;Learning;Length of Stay;Measures;Mechanical ventilation;Mentors;Mentorship;Methodology;Methods;Modeling;mortality;Nose;novel;Operative Surgical Procedures;Oxygen;Patient-Focused Outcomes;Patients;Perioperative;Perioperative Care;Physician Executives;Physicians;Population;Postoperative Period;Pragmatic clinical trial;predictive modeling;pressure;prevent;professor;programs;Prospective Studies;Protocols documentation;Provider;Randomized;Randomized, Controlled Trials;Reporting;Research;research and development;Research Design;Research Personnel;Research Project Grants;Risk;Risk Factors;risk prediction;Scientist;skills;Statistical Models;System;targeted treatment;Techniques;Testing;Time;Training;treatment as usual;United States;Validation;Weaning;Work

PROJECT_TITLE: Reducing Reintubation Risk in High-Risk Cardiac Surgery Patients with High-Flow Nasal Cannula -the "I-CAN" study

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Pediatric;Pediatric Cancer;Racial and Ethnic Minority Health Research;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Public Health Relevance Ewing sarcoma (ES) is the second most common bone tumor in children and adolescents. As survival for ES has not improved beyond ~60% in the last few decades, it is critical to understand its molecular underpinnings in order to improve therapy. The experiments outlined below represent a novel method for clarifying the molecular mechanisms that underlie ES, which if successful would uncover new pathways that could inform the development of novel therapies.

PI_NAMEs: WEBBER, BEAU RICHARD (contact)

PROGRAM_OFFICER_NAME: SHARMAN, ANU

PROJECT_TERMS: Adolescent;African;African American;African ancestry;Age;Asian;ATAC-seq;Automobile Driving;Binding;Biological Assay;Bone neoplasms;Candidate Disease Gene;candidate identification;Cell Line;cell repository;cell type;Cells;Child;Chromatin;Communities;Complex;CRISPR/Cas technology;Data;Data Set;Development;Disparity;Engineering;Epigenetic Process;Etiology;European;European ancestry;Ewings sarcoma;EWS-FLI1 fusion protein;Exhibits;experimental study;Fusion Oncogene Proteins;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;Genetic Engineering;Genetic Transcription;Genome;Genome engineering;genome-wide;Genomics;Germ Lines;Heterozygote;human induced pluripotent stem cells;Hybrids;improved;In Vitro;in vivo;Incidence;Individual;induced pluripotent stem cell;Intervention;Investigation;Knock-out;Knowledge;Latino;Link;Measures;Mesenchymal Stem Cells;mesenchymal stromal cell;metaplastic cell transformation;Methods;Modeling;Molecular;Neural Crest;Neural Crest Cell;novel;novel therapeutics;overexpression;Pathway interactions;Pattern;Pediatric Neoplasm;permissiveness;pharmacologic;Phenotype;Play;Population Genetics;programs;Protocols documentation;public health relevance;Regulatory Element;Research;Research Personnel;response;Risk;Risk Factors;Role;Sampling;Somatic Mutation;stem cell model;stem cells;System;Technology;Therapeutic;transcription factor;transcriptome;transcriptome sequencing;Validation;Variant;virtual;Xenograft Model

PROJECT_TITLE: Deconvoluting the Ewing sarcoma genetic program using ancestry-informed human iPSC modeling

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Hematology;Prevention;Primary Health Care;Regenerative Medicine;Skin Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: NARRATIVE Patients who receive hematopoietic cell transplantation (HCT) to cure their cancers face elevated risks for skin cancers in the future. We are testing which program best supports better and faster diagnosis of skin cancers: 1) teaching patients to perform skin self-examination and talk to their doctors, 2) teaching patients and their doctors to perform skin examinations, or 3) teaching patients and their doctors to perform skin examinations and doctors to take digital photographs for “tele”-dermatology support. We expect our results to improve detection of skin cancer in HCT survivors, and ultimately other high-risk cancer survivor populations.

PI_NAMEs: ARMENIAN, SARO  (contact);GELLER, ALAN CHARLES

PROGRAM_OFFICER_NAME: MOLLICA, MICHELLE A

PROJECT_TERMS: Address;advanced disease;Age;behavioral outcome;Cancer Burden;Cancer Detection;cancer diagnosis;Cancer Survivor;Cancer Survivorship;Cardiovascular system;Caring;Cellular Phone;Clinical;clinically relevant;comparative effectiveness study;conditioning;cost;cost effective;Coupled;Dermatologic;Dermatologist;Dermatology;Detection;Diagnosis;digital;E-learning;Early Diagnosis;Early treatment;Education;Educational process of instructing;Endocrine;Enrollment;Ensure;experience;Exposure to;Face;follow-up;Future;General Population;graft vs host disease;Health Promotion;health related quality of life;Hematologic Neoplasms;Hematological Disease;Hematology;Hematopoietic Stem Cell Transplantation;high risk;High-Risk Cancer;implementation science;improved;Individual;innovation;Knowledge;Late Effects;Lesion;Long-Term Care;Long-Term Survivors;Malignant Neoplasms;Measures;Medical;Melanoma;Morbidity - disease rate;mortality;multidisciplinary;Neoplasms;Oncology;Participant;Patients;Pattern;Physicians;Population;prevention practice;Preventive care;Primary Care;Primary Care Physician;primary care provider;primary care setting;Printing;programs;Provider;Quality of life;Radiation exposure;Randomized;Recurrence;Reporting;Research Priority;response;Risk;Risk Factors;screening;Screening for Skin Cancer;Self-Examination;skills;Skin;Skin Cancer;Skin Carcinoma;Survival Rate;Survivors;survivorship;Technology;Testing;Therapeutic immunosuppression;Time;transplant centers;Transplant Recipients;transplant survivor;Treatment-Related Cancer;United States National Institutes of Health;Whole-Body Irradiation

PROJECT_TITLE: Technology-Enabled Activation of Skin Cancer Screening for Hematopoietic Cell Transplantation Survivors and their Primary Care Providers


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Chronic Obstructive Pulmonary Disease;Clinical Research;Emphysema;Lung;Prevention;Pulmonary Fibrosis;Rheumatoid Arthritis

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Rheumatoid arthritis (RA) is a systemic inflammatory disorder affecting approximately 1.5 million adults in the United States; parenchymal lung disease, which includes interstitial lung disease and emphysema, is a common lung complication of RA associated with significant morbidity and mortality. This study aims to better define clinical and molecular features of early RA-associated parenchymal lung disease, thereby leading to improved non-invasive ways to identify those at risk for progressive disease. The results of this work have the potential to lead to earlier opportunities for intervention and improved outcomes in RA patients with interstitial lung disease and emphysema.

PI_NAMEs: SPARKS, JEFFREY ANDREW;WASHKO, GEORGE R (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Accounting;Activities of Daily Living;Address;Adult;Affect;Airway Disease;Area;Autoimmunity;Biological Markers;biomarker discovery;biomarker signature;Cause of Death;Cessation of life;Characteristics;Chronic;Chronic Obstructive Pulmonary Disease;Clinical;clinical phenotype;clinical risk;Complication;Data;Development;Disease;Early Diagnosis;Early identification;Early Intervention;effective therapy;fibrotic interstitial lung disease;fibrotic lung disease;follow-up;Gene Expression Profile;Gene Expression Profiling;health related quality of life;Health Status;High Prevalence;high risk;Hospitalization;improved;improved outcome;Individual;Inflammation;Inflammatory;Injury;insight;interstitial;Interstitial Lung Diseases;Intervention;Knowledge;Literature;Longitudinal cohort;Lung;Lung Diseases;lung injury;Measurement;Measures;Methods;Molecular;molecular phenotype;Molecular Profiling;Monitor;Morbidity - disease rate;mortality;MUC5B gene;Natural History;novel;Outcome;patient screening;Patients;Pattern;Persons;Phenotype;Physiological;Populations at Risk;pre-clinical;Predisposition;Prevalence;progression risk;Progressive Disease;Publishing;Pulmonary Emphysema;pulmonary function;Quality of Life Assessment;Radiology Specialty;Recording of previous events;Research;Respiratory Signs and Symptoms;Rheumatoid Arthritis;Risk;Risk Factors;risk stratification;Scoring Method;Smoking;Stress;Testing;Time;transcriptome sequencing;United States;Usual Interstitial Pneumonia;Variant;Visual;Work

PROJECT_TITLE: Rheumatoid Arthritis-associated Parenchymal Lung Disease: Clinical and Molecular Phenotypes

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Microbial communities in the cervicovaginal space are associated with spontaneous preterm birth. To truly advance the field and provide clinically relevant therapeutic targets, it is imperative that we more fully understand how the cervicocovaginal ecosystem leads to premature cervical remodeling and spontaneous preterm birth. Importantly, for the significant racial disparity in preterm birth, these studies are focused in black women in order to have the greatest impact on those at risk for this significant adverse health outcome.

PI_NAMEs: ELOVITZ, MICHAL AVIVA (contact)

PROGRAM_OFFICER_NAME: GIVENS-BRADLEY, SHANNON SHAREE

PROJECT_TERMS: Address;American;Bacterial Vaginosis;Biological;Biological Factors;Biological Response Modifiers;black women;Cervical;cervical remodeling;cervicovaginal;Cervix Uteri;Classification;clinically relevant;cohort;Communities;Data;Death Rate;Developed Countries;differential expression;Disease;Disparity;Ecosystem;Enrollment;ethnic diversity;Frequencies;Funding;Future;Gene Expression Profile;Genetic Variation;Health;high risk;host-microbe interactions;Human Microbiome;Immune;Immune response;Infant;Infant Mortality;innovation;insight;Intervention;Knowledge;Metabolic;metabolomics;metatranscriptomics;microbial;microbial community;microbial composition;microbiota;MicroRNAs;Molecular;multiple omics;novel;Outcome;Parents;Pathology;Phenotype;Positioning Attribute;Pregnancy;pregnant;premature;Premature Birth;Prospective cohort;Publishing;racial difference;racial disparity;racial diversity;Research;Risk;Role;Sample Size;screening;Second Pregnancy Trimester;Sex Behavior;Sexually Transmitted Diseases;social;Societies;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Time;transcriptomics;translational approach;translational impact;United States;Urinary tract infection;White Women;Woman;Women's cohort;women's reproductive health;Work

PROJECT_TITLE: The role of host-microbial interactions in altering preterm birth risk among black women

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative African American women experience a high burden of cardiometabolic diseases, including obesity, heart disease, and type 2 diabetes. Performing regular aerobic physical activity is an established behavior to prevent and manage these conditions. The purpose of this study is to test the efficacy of a culturally tailored, theory- based smartphone-delivered physical activity intervention to increase physical activity and improve cardiometabolic disease risk factors among sedentary African American women with obesity.

PI_NAMEs: JOSEPH, RODNEY  (contact)

PROGRAM_OFFICER_NAME: SHIROMA, ERIC JITSUO

PROJECT_TERMS: Accelerometer;Accountability;actigraphy;Address;Adherence;Adult;Aerobic;African American Women;Age;aged;Anti-Inflammatory Agents;Aorta;arm;Behavior;Biological;Biological Markers;Blood Pressure;Body mass index;burden of illness;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;cardiorespiratory fitness;Cardiovascular Diseases;cardiovascular fitness;Cardiovascular system;Cellular Phone;Characteristics;clinically relevant;Communities;Comparison arm;comparison control;comparison group;Computer software;Computer Vision Systems;Control Groups;cost comparison;cost effectiveness;Data;design;Devices;Diabetes Mellitus;Diagnosis;Diastolic blood pressure;Discrimination;disorder risk;Dose;Effectiveness of Interventions;efficacy testing;efficacy trial;eHealth;Ethnic Origin;exercise intervention;experience;fasting glucose;Feedback;fitbit;follow-up;Glucose Intolerance;group intervention;Guidelines;health disparity;Heart Diseases;Hispanic Women;Home;improved;Inflammatory;Insulin Resistance;Interleukin-10;Interleukin-15;Interleukin-6;Intervention;intervention effect;intervention participants;Link;Lipids;Lived experience;Measures;Mediation;Mediator;mHealth;moderate-to-vigorous physical activity;Monitor;mortality;Multimedia;National Heart, Lung, and Blood Institute;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Outcome;outcome prediction;Participant;participant retention;Patient Self-Report;Physical activity;physical inactivity;Physiologic pulse;Population;post intervention;pragmatic trial;preference;Prevalence;prevent;primary outcome;prognostic;Protocols documentation;Public Health;Race;racism;Randomized;randomized trial;Reduce health disparities;Research;Research Personnel;response;Risk Factors;secondary outcome;sedentary;Serum;Site;smartphone application;social cognitive theory;social culture;Social support;societal costs;Structural Racism;Structure;Surveys;Technology;Teleconferences;Telephone;Testing;Text;Text Messaging;theories;TNF gene;two-arm trial;vigorous intensity;virtual;walkability;Walking;walking intervention;Weight maintenance regimen;White Women;Woman;Work

PROJECT_TITLE: Smart Walk: A culturally tailored smartphone-delivered physical activity intervention to reduce cardiometabolic disease risk among African American women

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE  Oral drug delivery has multiple advantages over intravenous or injectable routes, including higher patient compliance, reduced complication rates, and ultimately lower cost and improved patient outcomes. A class of drugs called peptide macromolecules, which includes insulin as well as monoclonal antibodies indispensable to a wide variety of inflammatory conditions, cannot be given orally despite years of intense research. Here, we bring preliminary data built through 10+ years of NIH-funded multidisciplinary collaboration and propose to advance a new paradigm where these drugs can be given by mouth by small, millimeter-scale autonomous robots that can latch to the intestinal mucosa and inject these drugs into the systemic circulation.

PI_NAMEs: GRACIAS, DAVID H;SELARU, FLORIN  (contact)

PROGRAM_OFFICER_NAME: FALCONE, JESSICA

PROJECT_TERMS: absorption;adalimumab;Affect;Allergic Reaction;Anaphylaxis;Autoimmune;Autoimmune Diseases;Award;Blood Circulation;capsule;Circulation;Collaborations;Complication;cost;Data;Deglutition;design;Development;Devices;Diabetes Mellitus;Drug Delivery Systems;Encapsulated;Engineering;Epithelial Cell Junction;Funding;Gastroenterologist;gastrointestinal;Gastrointestinal tract structure;Generations;Goals;Healthcare Systems;Hospitalization;improved;In Vitro;in vivo;Infection;Inflammatory;Inflammatory Bowel Diseases;infliximab;Infusion procedures;Injectable;Injections;innovation;Insulin;Insulin Antibodies;Insulin-Dependent Diabetes Mellitus;Insurance;Interdisciplinary Study;Intestinal Mucosa;Intestines;Intravenous;Intravenous infusion procedures;macromolecule;manufacture;Measures;Medical;microrobot;millimeter;miniaturize;Monoclonal Antibodies;Mucous Membrane;National Institute of Biomedical Imaging and Bioengineering;Needles;Oral;Oral cavity;Outcome;parenteral administration;Patient Compliance;Patient Noncompliance;Patient-Focused Outcomes;Patients;Peptide antibodies;Peptide Hydrolases;Peptides;Performance;Persons;Pharmaceutical Preparations;Predisposition;Price;Productivity;Reaction;Regimen;Research;Rheumatoid Arthritis;Robot;Route;Safety;Scientist;Sepsis;side effect;Sterilization;Subcutaneous Injections;Systemic Lupus Erythematosus;Testing;Therapeutic;Therapeutic Effect;Thrombosis;thrombotic complications;Tissues;Treatment Efficacy;Treatment-related toxicity;United States National Institutes of Health

PROJECT_TITLE: Autonomous Grippers in the Gastrointestinal Tract

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

PHR: PROJECT NARRATIVE About one man in nine will be diagnosed with prostate cancer in their lifetime, about 80% of men who reach age 80 will have cancer cells in their prostate, but only one in 39 will die from it. Our ability to determine which patients will die is limited by our lack of understanding of how prostate cancer develops. The proposed studies will use new technologies to build better human models of prostate cancer to gain a better understanding of how prostate cancer develops.

PI_NAMEs: MIRANTI, CYNTHIA K (contact);ZOHAR, YITSHAK

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: Acceleration;Address;Age;Androgen Receptor;AR gene;Basal Cell;Basic Cancer Research;Biological Testing;Biology;Biomedical Engineering;cancer cell;carcinogenesis;Cell Differentiation process;Cell Line;Cell Survival;Cells;Coculture Techniques;Data;Dependence;Development;Diagnosis;Disease;Epithelial Cells;Epithelium;FGF10 gene;Fibroblasts;gene repression;Genetic Transcription;Gland;Human;human model;In Situ;in vivo;Individual;Maintenance;Malignant neoplasm of prostate;Malignant Neoplasms;man;MAP3K7 gene;Measures;Mediating;men;Microfluidic Microchips;Modeling;morphogens;neoplastic cell;new technology;NOTCH3 gene;Oncogenes;Oncogenic;Oranges;overexpression;Patients;Phenotype;Physiological;preservation;Proliferating;Prostate;prostate cancer model;receptor expression;Receptor Signaling;Repression;Signal Induction;Signal Transduction;Stratified Epithelium;Stromal Cells;Structure;Testing;Tissues;TNF gene;Transforming Growth Factor beta;translational cancer research;tumor;Tumor Cell Line;Tumor-Derived;tumorigenesis;tumorigenic

PROJECT_TITLE: Bioengineered Prostate-on Chip: Mechanisms of Stromal Dysregulation in Prostate Cancer

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Caregiving Research;Cerebrovascular;Clinical Research;Health Services;Mental Health;Neurosciences;Pain Research;Palliative Care;Physical Injury - Accidents and Adverse Effects;Stroke;Traumatic Head and Spine Injury

ORG_CITY: SEATTLE

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Severe acute vascular brain injuries encompassing ischemic stroke, intracerebral hemorrhage, and cardiac arrest are common, disabling, and often deadly. While palliative care is increasingly recognized as a specialty with expertise in reducing suffering and improving patient and family centered decision making in people with serious illness, there is a paucity of research specific to applying palliative care principles to individuals with severe acute brain injury. This project will help to define the scope of advanced, complex symptoms and needs for this common yet understudied population of seriously ill individuals in order to help design future specific interventions to reduce the emotional and psychological burden on patients and families.

PI_NAMEs: CREUTZFELDT, CLAIRE JOHANNA (contact);ZAHURANEC, DARIN B

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: Acute;Acute Brain Injuries;acute care;Address;Affect;Behavioral Symptoms;care fragmentation;Care given by nurses;care systems;caregiver strain;caregiving;Caring;Cerebral hemisphere hemorrhage;Cerebrovascular Trauma;Cessation of life;Characteristics;Clinical;Cohort Studies;Collaborations;Communication;Complex;curative treatments;Decision Making;Dementia;design;Dimensions;Disabling;Discipline of Nursing;Disease;Distress;Emotional;end of life;end of life care;Enrollment;evidence base;Exclusion;Face;Family;Family Caregiver;Family member;Frequencies;functional decline;functional outcomes;Future;Goals;Grief reaction;Health system;Healthcare Systems;Heart Arrest;Home;Hospice Care;hospice environment;Hospitals;improved;Individual;Individual Adjustment;Intervention;Interview;Investigation;Ischemic Stroke;Knowledge;Life;Location;Long term disability;Malignant Neoplasms;Measures;Medical Care Team;medical specialties;Methods;mortality;multidisciplinary;Nature;non-motor symptom;nursing intervention;Outcome;Outcome Assessment;Pain;palliative;Palliative Care;Pathway interactions;Patient Care;Patients;Pattern;Persons;Population;Population Intervention;Prevalence;primary care provider;prognostic;prospective;Prospective cohort;Provider;psychologic;psychological distress;psychological symptom;quality of death;Quality of life;Recovery;Rehabilitation Centers;Reporting;Research;Risk;routine care;Service delivery model;Services;Severity of illness;sociodemographics;Specialist;Spirituality;Supportive care;surrogate decision making;Survivors;Symptom Burden;Symptoms;therapy development;Time;Uncertainty;United States;Vulnerable Populations;Well in self;Work

PROJECT_TITLE: Comprehensive Outcome Assessment after Severe Acute Brain Injury: Advanced Symptoms and End-of-Life Care Needs

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: Project Narrative: Exosomes are microparticles released from many animal and human cells, which contain various bioactive lipids, endothelin, microRNAs or proteins such as enzymes. These exosomes may contribute to dysfunction of small heart arteries leading to ischemic heart disease (IHD) including heart attack. This grant application seeks to examine how exosome release is controlled in these arteries and how aggregation of the exosomes reduce heart blood flow, which will elucidate a novel mechanism that potentially causes IHD in addition to hardening of large heart arteries, helping develop new therapy in the future for more effective prevention or treatment of chest pain and heart attack due to IHD.

PI_NAMEs: LI, PINLAN  (contact)

PROGRAM_OFFICER_NAME: FLEG, JEROME L

PROJECT_TERMS: acute coronary syndrome;Address;Angina Pectoris;Angiography;Animals;Applications Grants;arterial remodeling;Arteries;arteriole;atherogenesis;Atherosclerosis;Blood;Blood flow;Cell Communication;Cell membrane;Cells;Ceramides;Chest Pain;Code;constriction;Coronary;Coronary Arteriosclerosis;Coronary artery;Coronary Vessel Anomalies;Development;Diagnosis;Endothelial Cells;Endothelin;Endothelin-1;Endothelium;Enzymes;exosome;Extracellular Matrix;Farber's lipogranulomatosis;Functional disorder;Future;galactosylgalactosylglucosylceramidase;Gene Deletion;Genes;Heart;Human;hypercholesterolemia;Impairment;Inflammasome;Inflammatory;insight;knockout gene;Knockout Mice;Lead;Lipids;Literature;Lysosomes;Mediating;Metabolism;MicroRNAs;Microvascular Dysfunction;microvesicles;Multivesicular Body;Mus;Muscle Contraction;Myocardial Infarction;Myocardial Ischemia;NADPH Oxidase;novel;novel therapeutics;particle;Pathogenesis;Pathogenicity;Pathologic;Pathology;Patients;Play;prevent;Prevention;Process;Prostaglandins;Proteins;Proteoglycan;receptor;Regulation;Relaxation;Reporting;response;Risk Factors;Role;Signal Transduction;Smooth Muscle;Smooth Muscle Myocytes;Sphingolipids;Sphingomyelins;Sphingosine;Stimulus;Stream;Testing;Thinness;trafficking;Vascular Diseases;vascular injury;Vesicle;western diet;Work

PROJECT_TITLE: Subendothelial Exosomes in Coronary Microvascular Dysfunction

STUDY_SECTION: HM

STUDY_SECTION_NAME: Hypertension and Microcirculation Study Section[HM]


NIH_SPENDING_CATS: Cancer

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: The overall goal of this proposal is to dissect the molecular mechanisms of metabolic regulation of ATP-citrate lyase (ACLY) and to characterize ACLY inhibitors for cancer therapy. Together, these studies will elucidate how cellular metabolites, and posttranscriptional and posttranslational modification, tune ACLY activity and will lead to the rational development of ACLY drugs to treat cancer.

PI_NAMEs: BURSLEM, GEORGE ;MARMORSTEIN, RONEN  (contact);WELLEN, KATHRYN ELAINE

PROJECT_TERMS: Acetyl Coenzyme A;Acetylation;Acetyltransferase;Acids;adduct;ATP Citrate (pro-S)-Lyase;Binding;Binding Sites;Biochemical;Biological Models;biophysical analysis;cancer cell;Cancer Model;cancer therapy;Carcinogens;Cardiovascular Diseases;Catalysis;Cell model;Cell Proliferation;Cells;Cholesterol;Citrates;Coenzyme A;Cryoelectron Microscopy;Data;Deacetylase;Dependence;Development;Diet;Disease;drug development;Enzymes;Exclusion;Exons;experimental study;Fatty Acids;FDA approved;Feedback;genetic regulatory protein;Glucose;Goals;Hand;Hepatocarcinogenesis;Hepatocyte;Histone Acetylation;Human;In Vitro;in vivo;Individual;inhibitor;inhibitor therapy;isoprenoid;Knockout Mice;Knowledge;Lead;lipid biosynthesis;Malignant neoplasm of liver;Malignant Neoplasms;Mediating;Metabolic;Metabolic Diseases;Mitochondria;Modification;Molecular;Molecular Conformation;mouse model;Mus;Mutagenesis;mutant;Normal Cell;novel;Oxaloacetates;PCAF gene;Pharmaceutical Preparations;Phenotype;Phosphorylation;Phosphorylation Site;Positioning Attribute;Post-Translational Protein Processing;posttranscriptional;Primary carcinoma of the liver cells;Production;Program Development;Protein Acetylation;Protein Isoforms;Protein Subunits;Reaction;Regulation;Reporting;Risk;RNA Splicing;Role;Site;Source;Structure;Testing;Therapeutic Uses;tumor;tumor metabolism;Validation;Work

PROJECT_TITLE: Metabolic regulation and inhibition of ATP-citrate lyase

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Lymphatic Research;Lymphoma;Racial and Ethnic Minority Health Research;Rare Diseases;Rural Health;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE NHL is the most common hematologic malignancy, and there are many unmet clinical and public health needs of this growing patient population. The goal of this infrastructure grant is to support a cohort of over 16,000 non-Hodgkin lymphoma (NHL) patients in order to address broad and cutting-edge research that identifies clinical, epidemiologic (including lifestyle and other exposures), host genetic, tumor, and treatment factors, and the interaction among these factors, on short and long-term outcomes. These efforts will identify new approaches to improve the survival and well-being of NHL patients.

PI_NAMEs: CERHAN, JAMES R (contact);FLOWERS, CHRISTOPHER R

PROGRAM_OFFICER_NAME: SHELBURNE, NONNIEKAYE F

PROJECT_TERMS: Address;Adolescent and Young Adult;African American;African American population;Age;Asian;Automobile Driving;biobank;Biological;Biometry;Blood specimen;Cause of Death;Clinic;Clinical;Clinical Data;clinical practice;Clinical Research;Clinical Trials;Clinical Trials Network;cohort;Cohort Studies;Data;Data Collection;design;Development;Diagnosis;digital imaging;digital pathology;Disease Progression;DNA;Electronic Health Record;Enrollment;Environmental Exposure;epidemiologic data;Epidemiology;epidemiology study;Ethnic Origin;follow-up;Formalin;Fostering;Foundations;Funding;General Population;Genetic;Germ Lines;Goals;Grant;Growth;Health;Hematologic Neoplasms;Hispanic;improved;Incidence;Industry;Informatics;Infrastructure;insight;International;K-Series Research Career Programs;Knowledge;Life Style;Lymphoma;Malignant Neoplasms;Minority Groups;Newly Diagnosed;Non-Hodgkin's Lymphoma;non-Hodgkin's lymphoma patients;novel;novel strategies;Outcome;Paraffin Embedding;Participant;Pathology;pathology imaging;patient advocacy group;Patient Outcomes Assessments;patient population;Patients;peripheral blood;Personal Satisfaction;Persons;Plasma;Population;Prognosis;prospective;Provider;public database;Public Health;Publications;Race;radiological imaging;recruit;Relapse;Research;Research Methodology;Research Personnel;Research Priority;Research Project Grants;residence;Resources;Retreatment;Risk;risk stratification;RNA;rural patients;Rural Population;Sample Size;Science;Second Primary Cancers;Serum;Site;Slide;Socioeconomic Factors;Specimen;Statistical Models;Survival Rate;Survivors;survivorship;Tissue Microarray;Tissue Sample;Translations;Treatment Factor;treatment strategy;trend;tumor;Tumor Bank;tumor DNA;Update;Validation

PROJECT_TITLE: The Lymphoma Epidemiology of Outcomes (LEO) Cohort Study

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Gene Therapy;Genetics;Immunotherapy;Machine Learning and Artificial Intelligence;Precision Medicine

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: PROJECT NARRARATIVE CAR T cells have the potential to recognize and specifically kill cancer cells, making them the target of extensive anti-cancer drug development research. This proposal will use a novel technology for monitoring the activation state of a T cell, a protein-interaction-network based approach called Quantitative Multiplex co-Immunoprecipitation, or QMI. Our goal is to identify a protein interaction network state indicative of clinical performance, and to better understand the molecular mechanisms responsible for CAR T cell efficacy.

PI_NAMEs: SMITH, STEPHEN EDWARD PAUCHA (contact)

PROGRAM_OFFICER_NAME: COUCH, JENNIFER A

PROJECT_TERMS: Affinity;Antibodies;Antigens;Antineoplastic Agents;autism spectrum disorder;Autoimmune Diseases;B-Cell Lymphomas;Binding;Bioinformatics;Biological Markers;Biomedical Engineering;biosignature;cancer cell;cancer therapy;Cancerous;CD19 gene;CD22 gene;CD28 gene;cell behavior;Cell Communication;cell killing;Cell Surface Receptors;cell type;Cells;cellular transduction;Child;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;clinical efficacy;clinical implementation;clinical predictors;clinical translation;Clinical Trials;clinically relevant;Co-Immunoprecipitations;Collecting Cell;Communities;computer infrastructure;Custom;cytokine;cytokine release syndrome;Data;density;design;Development;Disease;Disease remission;Engineering;Event;extracellular;Fc Receptor;Genetic;Goals;Grant;graphical user interface;Immunology;improved;In Vitro;in vivo;Individual;individual variation;interest;ITAM;K-562;Lead;leukemia;Logic;lymphoblast;Lymphocyte;Machine Learning;machine learning prediction algorithm;manufacture;Mass Spectrum Analysis;Measurable;Measurement;Measures;Molecular;molecular modeling;Monitor;nano-string;Network-based;neurochemistry;neuropsychiatric disorder;neurotoxicity;new technology;novel;Outcome;Outcome Measure;Pathway Analysis;Patient-Focused Outcomes;Patients;Performance;personalized medicine;personalized predictions;Population;prediction algorithm;predictive marker;predictive test;Production;programs;protein protein interaction;Proteins;Proteomics;Publishing;receptor;Receptor Signaling;Recording of previous events;Refractory;Relapse;research and development;research clinical testing;Research Institute;Research Personnel;Research Project Grants;response;Sampling;Science;side effect;Signal Transduction;Source;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Techniques;Technology;Testing;transcriptome;Translating;Variant;Viral Vector

PROJECT_TITLE: Quantitative protein network profiling to improve CAR design and efficacy

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]