ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: COLLEGE PARK

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: Project Narrative  Cryptococcus neoformans is a pathogenic fungus that causes fatal meningoencephalitis in immunocompromised individuals including HIV/AIDS patients worldwide. In this project, mechanisms involved in regulating cryptococcal IRIS will be studied using a murine model that reproduces key aspects of cryptococcal IRIS of HIV/AIDS patients. Understanding the mechanisms involving in regulating cryptococcal IRIS of HIV/AIDS patients is fundamental for developing therapeutic strategy for this disease.

PI_NAMEs: SHI, MEIQING  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affect;Anti-Inflammatory Agents;antiretroviral therapy;blood-brain barrier crossing;Brain;Brain Injuries;brain size;CD4 Positive T Lymphocytes;Cell secretion;Cells;Cellular Immunity;Cerebrospinal Fluid;Cessation of life;Clinical;Clinical Data;Coma;Cryptococcosis;Cryptococcus;Cryptococcus neoformans;Cryptococcus neoformans infection;cytokine;Disease;Encephalitis;Equilibrium;FOXP3 gene;fungus;Genes;Genetic Polymorphism;Growth;HIV;HIV Seronegativity;HIV Seropositivity;HIV/AIDS;Human;Immune;immune reconstitution;Immune response;Immunity;Immunocompromised Host;immunopathology;immunoregulation;Impairment;improved;Individual;Infection;Inflammation;Inflammatory;Inflammatory Response;Inhalation;Interleukin-10;interleukin-10 receptor;Life;Lung;Maintenance;Mediating;Meningoencephalitis;Microbe;migration;Molecular;mortality;mouse model;mRNA Expression;Mus;Mycoses;Outcome;pathogen;pathogenic fungus;Patients;Persons;Play;Predisposition;prevent;Production;Proliferating;Property;receptor;Regulation;Regulatory T-Lymphocyte;response;Role;Severities;Signal Transduction;Source;Syndrome;Testing;Therapeutic;therapeutic development

PROJECT_TITLE: Mechanisms of balancing the immune response during cryptococcal meningoencephalitis

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Hematology;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Project Narrative Recent genomic studies have uncovered many novel putative oncogenes and tumor suppressors of B-cell lymphomas, but these remain to be functionally validated and characterized. Among the most common and co- occurring genomic alterations is a mutation in the MYD88 gene (MYD88L265P), and a large deletion of chromosome 6 (Chr6q deletion), which are exceptionally frequent among two important subtypes of B-cell lymphomas, lymphoplasmacytic lymphoma (LPL) and diffuse large B-cell lymphoma of activated B-cell type (ABC-DLBCL). Therefore, the studies proposed here to study the molecular mechanisms by which MYD88L265P mutation, Chr6q deletion and other LPL/ABC-DLBCL-associated genomic alterations induce lymphomagenesis will significantly move the field forward to provide discoveries which improve diagnosis, evaluate prognosis and lead to the development of novel and more effective therapies as well as cellular and organismal models to treat these and other types of B-cell lymphomas.

PI_NAMEs: CARRASCO, RUBEN D (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Accounting;activated B cell like;Adaptor Signaling Protein;Animal Model;B lymphoid malignancy;B-Cell Activation;B-Cell Development;B-Cell Lymphomas;B-Cell NonHodgkins Lymphoma;B-Lymphocytes;Binding;Biochemical;Biological Models;Cell Line;Cell model;cell type;Chromosome 6;Chromosome Deletion;Clinical;Clinical Engineering;clinically relevant;cohort;Comparative Study;Correlative Study;CRISPR/Cas technology;Data;deletion detection;Development;Diagnosis;Disease;Disease Progression;DNA Sequence Alteration;drug sensitivity;effective therapy;Feedback;Frequencies;Gene Mutation;Generations;Genes;Genetic;Genomics;Hematologic Neoplasms;Hematopoietic stem cells;Human;Immunocompetent;Immunotherapy;improved;in vivo;Incidence;Indolent;insight;large cell Diffuse non-Hodgkin's lymphoma;Leucine;loss of function;Lymphoma;Lymphoma cell;Lymphomagenesis;Lymphoproliferative Disorders;Malignant lymphoid neoplasm;Malignant Neoplasms;Mass Spectrum Analysis;Mature B-Lymphocyte;Mediating;Medical;Missense Mutation;Modeling;Molecular;mouse model;Mus;mutant;Mutation;Neoplastic Cell Transformation;Non-Hodgkin's Lymphoma;novel;Nuclear Translocation;Oncogenes;Oncogenic;Outcome;overexpression;p65;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Point Mutation;Positioning Attribute;PRDM1 gene;pre-clinical;Predisposition;Prognosis;Proline;Property;Proteins;Proteomics;Repression;Research;Role;Sampling;Side;Signal Transduction;Structure of germinal center of lymph node;System;Testing;transcriptomics;Transgenic Mice;Transgenic Organisms;tumor;Tumor Suppressor Proteins;tumor-immune system interactions;Waldenstrom Macroglobulinemia;Work;Writing

PROJECT_TITLE: Investigating and modeling MYD88L265P and co-occurring  mutations in mature B-cell malignancies

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: ALBUQUERQUE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Project Narrative Various adverse and protective environments may affect child development. The Healthy Brain and Child Development National Consortium (HBCD-NC) will follow 7,500 mothers and their children from 24 locations across the U.S. from before birth to 10 years of age to better understand which harmful and protective environments exert the greatest impact on child development. This study will help to improve the health and development of children across the nation.

PI_NAMEs: BAKHIREVA, LUDMILA NICOLE (contact);LEEMAN, LAWRENCE M

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: 10 year old;Address;Adverse event;Affect;Alcohols;Behavioral;Biological;Birth;Brain;Caregivers;caregiving;Child;child bearing;Child Development;cohort;Communities;Conceptions;COVID-19;critical period;Data;Data Collection;Data Coordinating Center;data integrity;Data Set;data standards;design;Development;DNA;early experience;early life exposure;Electroencephalography;Enrollment;Environment;Environmental Exposure;Environmental Hazards;Epigenetic Process;Ethics;Ethnic Origin;Event;experience;Exposure to;Feedback;General Population;Genes;Goals;hazard;Health;Helping to End Addiction Long-term;Human;improved;Infant;Infection;innovation;insight;Life;Link;Location;Magnetic Resonance Imaging;Malnutrition;maltreatment;Marijuana;Maternal Health;maternal stress;Measures;Methods;Modality;Monitor;Mothers;multidimensional data;multimodality;neurodevelopment;neuroimaging;Newborn Infant;novel;Opiate Addiction;Opioid;opioid misuse;Outcome;Participant;Persons;Physiological;Population;postnatal;Pregnancy;pregnant;Pregnant Women;prenatal;prenatal exposure;Process;protective factors;Protocols documentation;psychologic;Psychopathology;Public Health;Public Policy;Race;recruit;remote assessment;Research;Research Design;Research Personnel;Sampling;Second Pregnancy Trimester;Severities;Shapes;Site;socioeconomics;sound;Speed;stem;Stress;Structural Racism;substance use;Time;Time Study;Tobacco;tool;Toxicant exposure;Training;United States;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: 18/24 Healthy Brain and Child Development National Consortium

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-D(51)R]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Brain Disorders;Childhood Injury;Clinical Research;Depression;Genetics;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Serious Mental Illness;Suicide;Suicide Prevention;Violence Research;Youth Violence

ORG_CITY: BIRMINGHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Suicide is the 2nd leading cause of death in adolescents, but our ability to predict and prevent suicidality is remarkably limited. MicroRNAs are important transducers of environmental effects on gene expression. We will test if microRNAs are associated with suicidality, by using brain-derived plasma exosomal microRNAs from peripheral blood, and examine if they can be used as ‘‘molecular tools’’ to identify suicide and depression risk.

PI_NAMEs: DWIVEDI, YOGESH  (contact);SHELTON, RICHARD CHARLES

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Adolescent;Adolescent and Young Adult;adolescent suicide;Adult;Affect;Aftercare;Age;age difference;age group;Aggressive behavior;anti-depressive agents;Biological;Biological Markers;biosignature;Blood;Brain;Cause of Death;Child;Child Abuse and Neglect;Clinical;Data;Data Set;Development;Diagnosis;differential expression;Disease;disorder risk;exosome;Feeling suicidal;Future;Gene Expression;Gene Targeting;Genes;genome-wide;Hostility;improved;Impulsivity;Individual;interest;Ketamine;Major Depressive Disorder;Maps;Mediator;Mental Depression;Mental disorders;MicroRNAs;Molecular;Moods;neural;Neurons;new therapeutic target;novel;novel marker;novel strategies;Pathogenesis;Pathology;Pathway interactions;Patients;Pattern;peripheral blood;Plasma;Population;posttranscriptional;Prevalence;prevent;Psychopathology;Public Health;Recording of previous events;Regulatory Pathway;Reporting;response;Risk;suicidal;suicidal adolescent;suicidal patient;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Testing;tool;tool development;trait;Transducers;Treatment outcome;treatment response;Untranslated RNA;Variant;Youth

PROJECT_TITLE: Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: NARRATIVE The goal of our proposal is to achieve equitable access to state-of-the-art genomic medical care to sick newborns in community centers that predominately care for low-income and racial/ethnic minority populations through the creation of a virtual genome center (VIGOR). VIGOR will provide a venue for physician and family education, genomic expert consultation, reanalysis of unsolved sequencing data, and access to cutting edge therapeutic innovation, thereby facilitating institutionalization of genomic best practices in community settings, and not just highly specialized referral centers.

PI_NAMEs: AGRAWAL, PANKAJ B;PARKER, MARGARET GRAHAM KEMPER;YU, TIMOTHY WEI-WEN (contact)

PROGRAM_OFFICER_NAME: RIDER, RENEE ANNE

PROJECT_TERMS: access disparities;Address;age group;All of Us Research Program;biomedical referral center;care seeking;Caring;Clinical;clinically actionable;Communication;Communities;community center;community setting;Complex;congenital anomaly;Consultations;Data;Data Analyses;Diagnosis;Diagnostic;Disease;Disparity;disparity gap;Disparity population;Early Diagnosis;Education;Eligibility Determination;Enrollment;Equity;ethnic minority;ethnic minority population;Ethnic Origin;Evaluation;exome sequencing;experience;Face;Family;family support;Funding;Genetic;Genetic Diseases;genetic testing;Genome;Genomic medicine;Genomics;Goals;health care disparity;health equity;Health system;Hospitals;immunodeficiency;implementation evaluation;implementation outcomes;improved;Infant Health;Infrastructure;innovation;insight;Institutionalization;Insurance Coverage;Intervention;Knowledge;Language;Low income;Low Income Population;Medical;Medicine;Mental Depression;Mental Health;Metabolic Diseases;Minority Groups;Modeling;Muscle hypotonia;Neonatal Intensive Care Units;Newborn Infant;novel;Outcome;outcome disparities;Patient Care;Patients;Penetration;personalized medicine;Physicians;Population Heterogeneity;Probability;Provider;Race;racial minority;racial minority population;Recommendation;Reporting;Research;Research Personnel;Resources;response;satisfaction;Seizures;Signs and Symptoms;social disparities;Specialized Center;Stress;Target Populations;Techniques;Testing;Therapeutic;Transportation;Underrepresented Minority;United States National Institutes of Health;virtual;Work

PROJECT_TITLE: VIGOR: Virtual Genome Center for Infant Health


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Violence Research

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE This project seeks to describe the neurobiological and behavioral processes underlying a critical dimensional phenotype of depressive illness, Angry Hostility, which refers to the tendency to experience anger, hostility, and irritability following negative experiences and to respond in an aggressive, overly hostile manner. We will examine whether this phenotype is associated with specific patterns of abnormal brain function and behavior in emotional contexts. Findings will help us to identify neurobiological targets that we could use to develop more effective, individually tailored treatments for adults with depression who have high levels of Angry Hostility.

PI_NAMEs: FOURNIER, JAY C (contact)

PROGRAM_OFFICER_NAME: SABBAGH, JONATHAN JACOB

PROJECT_TERMS: Adult;Age;Aggressive behavior;Amygdaloid structure;Anger;Area;Attention;base;Behavior;Behavior assessment;Behavioral;Behavioral Mechanisms;brain dysfunction;burden of illness;Clinical;Clinical assessments;Code;Data;Depressed mood;depressive symptoms;Detection;Development;Diagnostic;Dimensions;disability;Ecological momentary assessment;Elements;emotion regulation;Emotional;Emotions;Evaluation;experience;extrastriate;extrastriate visual cortex;Face;Feedback;follow up assessment;follow-up;Functional impairment;functional improvement;functional outcomes;Fusiform gyrus;Future;Goals;high risk;Hostility;Impairment;improved outcome;Individual;individualized medicine;Inferior frontal gyrus;Insula of Reil;Laboratories;Lead;Life;Link;Measures;Mediating;Mental Depression;Middle frontal gyrus structure;Modeling;Motor;National Institute of Mental Health;neural;Neural Pathways;neurobehavioral;Neurobiology;neuroimaging;neuromechanism;Neuronal Dysfunction;Neurophysiology - biologic function;novel;Outcome;Participant;Patients;Pattern;personalized medicine;Phenotype;Prefrontal Cortex;Process;prospective;Protocols documentation;psychiatric symptom;Quality of life;Recording of previous events;recruit;reduce symptoms;Regulation;response;Risk;Sensory;Severities;sex;Short-Term Memory;Standardization;stressor;suicidal risk;Support System;Symptoms;System;Testing;therapy development;treatment strategy;Visual;Work

PROJECT_TITLE: Neural and Behavioral Mechanisms of Angry Hostility in Depression

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Mexican American families share similar elevated risks for obesity and obesity-related conditions, such as type 2 diabetes. Because negative family interactions and relationships (e.g., poor communication, high conflict, low emotional closeness) are associated with obesity treatment outcomes, this study tests a behavioral weight management intervention that provides relationship skills counseling to mothers and adult daughters. The goal is to improve family interaction patterns to buffer challenges and strengthen collaboration for eating and physical activity behaviors that support long-term weight management and thus provide an effective obesity treatment approach to address a major public health concern.

PI_NAMEs: MARQUEZ, BECKY  (contact)

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: Acculturation;Address;Adherence;Adoption;Adult;Adult Children;Age of Onset;Age Years;Attitude;Behavior;behavior change;Behavior Therapy;Behavioral;Belief;Body fat;Body mass index;Body Weight Changes;Body Weight decreased;Buffers;Child;Code;cohesion;Collaborations;commune;Communication;Competence;Conflict (Psychology);coping;Counseling;Couples Therapy;cultural competence;Daughter;depressive symptoms;diabetes management;Diabetes Mellitus;diabetes risk;Diet;Disproportionately impacts women;Eating;Educational Activities;Effectiveness of Interventions;efficacy testing;Emotional;expectation;experience;Family;Family history of;Family member;follow-up;Glycosylated hemoglobin A;Goals;Health behavior;Health Benefit;improved;Individual;intergenerational;Intervention;intervention effect;K-Series Research Career Programs;lifestyle intervention;Link;Literature;Maintenance;Mediation;member;Mental Depression;Mentors;Mexican Americans;Modification;Monitor;Mothers;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;nutrition;Obesity;obesity risk;obesity treatment;Outcome;Parents;Participant;Patient Self-Report;Pattern;perceived stress;Phase;Physical activity;Physiological;Prevalence;Prevention;primary outcome;Problem Solving;psychological distress;Public Health;Randomized;Randomized, Controlled Trials;Recording of previous events;Records;Reporting;Research;Risk;Role;secondary outcome;skills;skills training;Structure;success;System;Techniques;Testing;Training;Translating;treatment adherence;treatment disparity;Treatment outcome;waist circumference;Weight;weight loss intervention;weight maintenance;Weight maintenance regimen;Well in self;White Women;Woman;young adult

PROJECT_TITLE: Improving Family Functioning in Obesity Treatment for Mexican American Women

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Networking and Information Technology R&D (NITRD);Patient Safety;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Many patients for whom the results of genetic testing change medical management are not currently getting such testing. Utilizing that infrastructure, we propose a highly innovative study using implementation science to study nudges in the electronic health record (EHR) to influence both clinicians and patients to increase the use of genetic testing in clinical care, building upon the infrastructure that we have already built to deliver genomic medicine in the EHR. Further, we plan structured dissemination of all existing and planned protocols and EHRbased algorithms.

PI_NAMEs: NATHANSON, KATHERINE L. (contact);RITCHIE, MARYLYN D;SCHNOLL, ROBERT ADAM

PROJECT_TERMS: Address;Adopted;Adverse effects;Age;Algorithms;Appointment;Architecture;Area;behavioral economics;Caring;Clinic;Clinical;clinical care;clinical decision support;Clinical effectiveness;clinical encounter;Clinical Trials;cloud based;cluster randomized design;Communication;Communities;cost;Coupled;Decision Making;Development;Diagnosis;disease-causing mutation;effectiveness evaluation;effectiveness outcome;Electronic Health Record;Electronics;Eligibility Determination;Environment;evidence base;Fostering;Gender;Genetic;Genetic Models;genetic testing;Genomic medicine;Genomics;Health;health disparity;Health system;Healthcare;Hereditary Disease;Hospitals;Human;Hybrids;implementation barriers;implementation framework;implementation outcomes;implementation science;implementation strategy;implementation study;implementation trial;improved;Infrastructure;Ingestion;Inherited;innovation;Institution;Instruction;Integrated Health Care Systems;Knowledge;Libraries;Measures;Medical;medical specialties;Methods;Minority;Modeling;novel;Outcome;Pathogenicity;patient health information;patient-level barriers;Patients;phenotyping algorithm;Physicians;Probability;Protocols documentation;Provider;Race;racial minority;Randomized;randomized, clinical trials;Role;Specialist;Structure;structured data;System;system-level barriers;Systems Integration;Testing;theories;Time;tool;Translations;treatment arm;Uncertainty;Variant;videoconference;web site;Work

PROJECT_TITLE: Using Behavioral Economics and Implementation Science to Advance the Use of Genomic Medicine Utilizing an EHR Infrastructure across a Diverse Health System


ADMINISTERING_IC: EY

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cerebrovascular;Eye Disease and Disorders of Vision;Neurosciences;Regenerative Medicine

ORG_CITY: Rochester

ORG_NAME: RETINAL SOLUTIONS LLC

ORG_STATE: MI

PHR: NARRATIVE In this SBIR Phase II project, Caeregen Therapeutics (formerly Retinal Solutions, LLC) plans to develop NoregenTM, a regenerative therapy for ischemic retinopathies, such as diabetic retinopathy (DR) and retinal vein occlusion (RVO), which are the leading cause of blindness in the United States. This will lessen suffering of patients who must endure repeated office visits and repeated intravitreal injections, as current therapies only serve to slow progression of the disease and vision loss.

PI_NAMEs: DRENSER, KIMBERLY  (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: Ablation;Address;Affect;analytical method;analytical ultracentrifugation;Animal Model;Area;AXIN2 protein;beta catenin;bevacizumab;Biodistribution;Biological;Blindness;blocking factor;Blood - brain barrier anatomy;Blood capillaries;Blood Vessels;Businesses;Clinical Trials;commercial application;Contracts;Development;Diabetic Retinopathy;dimer;Disease Progression;dosage;Dose;Drops;Drug Kinetics;Edema;Endothelial Cells;endothelial stem cell;Enzyme-Linked Immunosorbent Assay;Escherichia coli;Exclusion;Exudate;Eye;Funding;Gene Expression;Goals;Good Manufacturing Process;Growth;Growth Factor;Half-Life;Hour;Human;Hypoxia;In Vitro;in vivo;in vivo Model;Injections;innovation;International;intravitreal injection;Investigational Drugs;Ischemia;Knowledge;Lasers;Legal patent;light scattering;liquid chromatography mass spectrometry;manufacture;Marketing;Measures;Methods;mimetics;Modeling;Molecular Weight;monomer;Mus;Natural regeneration;neovascularization;neurovascular injury;neurovascular unit;novel therapeutics;Office Visits;Oryctolagus cuniculus;Outcome;Oxygen;Pathology;Patients;Persons;Pharmaceutical Preparations;Phase;phase 1 study;preservation;Process;Qualifying;Recombinants;Regenerative Medicine;regenerative therapy;repaired;response;Retina;retina blood vessel structure;Retinal Detachment;Retinal Diseases;retinal regeneration;Retinal Vein Occlusion;Running;Safety;Sampling;scale up;sedimentation velocity;Serum;sight restoration;Signal Transduction;Small Business Innovation Research Grant;Stains;Steroids;Swelling;technological innovation;Testing;Therapeutic;therapeutic candidate;Time;Toxicology;United States;Variant;vascular abnormality;Vascular Endothelial Cell;Vascular Endothelial Growth Factors;Vascular Permeabilities;Vision

PROJECT_TITLE: Noregen, a regenerative medicine ocular therapeutic


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: OMAHA

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Relevance: Twin epidemics are now affecting Americans: the decades-long HIV pandemic, in which over 675,000 have died and approximately 1.3 million are currently living with HIV; and the recent opioid crisis, killing approximately 130 people a day and with 2.1 million people having an opioid abuse disorder. There is a considerable intersection between the populations affected by HIV and opioids, as well as a common site of damage, the brain. New single-cell technologies can provide new insight into the effects of HIV and opioids on specific brain cells. We will combine these with virologic studies on the brain to yield insight in ways to prevent and/or treat damage to the brain.

PI_NAMEs: BUCH, SHILPA J.;FOX, HOWARD S (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Address;Affect;American;Animal Model;Animals;Anti-Retroviral Agents;antiretroviral therapy;Biological Assay;Biological Markers;Brain;brain cell;Brain region;CD4 Positive T Lymphocytes;Cell Culture Techniques;Cell Separation;cell type;Cells;Chromatin;Chronic;clinically relevant;cocaine exposure;combinatorial;Controlled Study;Corpus striatum structure;Coupled;Critical Pathways;Data;data mining;Data Set;design;Disease;DNA;Drug abuse;drug of abuse;Ensure;Epidemic;epigenetic regulation;epigenomics;Experimental Designs;experimental group;experimental study;FAIR principles;follow-up;Future;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic Transcription;HIV;HIV Infections;HIV-1;Human;Immune;Immunohistochemistry;In Situ Hybridization;Individual;Infection;Injections;insight;interdisciplinary approach;Knowledge;Lymphocyte;Macaca mulatta;Macrophage;Mediating;member;methamphetamine exposure;Microglia;Modeling;Molecular;monocyte;Morphine;National Institute of Drug Abuse;Neuroglia;Neurons;Neuropathogenesis;nonhuman primate;novel;Opioid;opioid abuse;opioid epidemic;opioid exposure;opioid use;outreach;pandemic disease;Pathogenesis;Pathogenicity;Pathway interactions;Persons;Pharmaceutical Preparations;Phenotype;Population;power analysis;Predisposition;Prefrontal Cortex;prevent;Primates;programs;Protein Isoforms;Randomized;Reproducibility;Research;response;RNA;Role;Saline;Sample Size;single cell ATAC-seq;single cell technology;single-cell RNA sequencing;Site;SIV;System;Systems Biology;Techniques;Therapeutic Intervention;transcriptome;transcriptome sequencing;Twin Multiple Birth;Validation;Variant;Viral;Viral Genome;Viral Pathogenesis;Viral reservoir;Virus;Work

PROJECT_TITLE: Uncovering HIV/opioid effects in the brain at the single cell level: transcription, chromatin accessibility, and reservoir analysis in the SIV/cART/morphine/rhesus monkey model


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: OVERALL CENTER NARRATIVE The central theme of the proposed Program is to define specific aspects of environmental, microbial and mammalian biomolecular responses to environmental contaminants (dioxin and dioxin-like compounds) that act as ligands for the aryl hydrocarbon receptor (AhR). Emphasis will be on two major areas: (a) characterize specific biological, physical and chemical criteria governing the environmental fate of AhR ligands; and (b) develop state of the art remediation technology to reduce toxicity of AhR ligands.

PI_NAMEs: ZACHAREWSKI, TIMOTHY R. (contact)

PROGRAM_OFFICER_NAME: HENRY, HEATHER F

PROJECT_TERMS: Academia;Adsorption;Adverse effects;advocacy organizations;Affect;Agonist;Animal Model;Archives;Area;Aromatic Hydrocarbons;Aromatic Polycyclic Hydrocarbons;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Bacteria;Behavior;Binding;bioaccumulation;Biochemical Pathway;Biological;Biological Availability;Biological Models;Biomedical Engineering;Carbon;Chemicals;Cities;Cobalamin;Collaborations;Communication;Communities;community engaged approach;community engagement;community research;Computer Models;contaminated sediment;County;Data;Data Analyses;data management;Data Science;Data Set;dibenzo(1,4)dioxin;dibenzofuran;Dioxins;Disparate;Dose;dosimetry;dynamic system;Ensure;Environment;Environmental Engineering technology;Environmental Health;Environmental Pollutants;Environmental Pollution;evidence base;experience;Exposure to;Family;Food Chain;Future;Genetic Engineering;geochemistry;Goals;Government;Government Agencies;ground water;halogenation;Health;Hepatic;Homeostasis;Human;human model;Immune;immune function;Immune response;improved;Industry;Interdisciplinary Study;Investigation;investigator-initiated translational research;Knowledge;Learning;Ligands;Lipids;Liver;Mediating;Metabolic Biotransformation;Metadata;Methods;Michigan;microbial;microorganism;Modeling;Molecular;molecular modeling;multidimensional data;Native-Born;next generation;novel;Organ;Organism;Pathway interactions;physiologically based pharmacokinetics;pollutant;Postdoctoral Fellow;pre-doctoral;programs;Public Health;Recommendation;remediation;Reproducibility;Research;Research Personnel;Research Project Grants;Research Support;Resources;response;Risk;Risk Assessment;Science;Scientist;single-cell RNA sequencing;Site;Soil;Superfund;superfund site;Techniques;Technology;Technology Transfer;Tetrachlorodibenzodioxin;Thyroid Gland;Tissues;tool;Toxic effect;Toxicant exposure;Training;Training and Infrastructure;Translational Research;United States Dept. of Health and Human Services;Universities;Work

PROJECT_TITLE: Environmental, Microbial and Mammalian Biomolecular Responses to AhR Ligands


NIH_SPENDING_CATS: Agent Orange & Dioxin;Endocrine Disruptors;Immunotherapy

PHR: PROJECT NARRATIVE Dioxin-like halogenated aromatic hydrocarbons (DLC) are ubiquitous environmental contaminants that suppress antibody responses. A population of white blood, termed CD5+ B cells, is exquisitely sensitive to suppression by DLC and accounts for impairment of antibody responses. This project uses human white blood cells to elucidate the mechanism by which DLC suppress antibody responses in CD5+ B cells and also proposes to use the percentage of circulating CD5+ B cells as an indicator of human sensitivity to immune suppression by DLC.

PI_NAMEs: KAMINSKI, NORBERT E (contact)

PROJECT_TERMS: Adaptive Immune System;adaptive immunity;Affinity;Agonist;AHR gene;Amendment;Antibody Formation;Antibody Response;Antibody Suppression;Aromatic Hydrocarbons;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;B-Lymphocytes;Biochemical Pathway;Biological;Biological Availability;Biological Markers;Blood;Calibration;Carbon;cell type;Cells;Collaborations;Computer Models;differential expression;Dioxins;Environmental Pollutants;Epidemiology;Exhibits;experimental study;Genes;Goals;halogenation;Human;Humoral Immunities;Immune;Immune checkpoint inhibitor;Immune response;Immunity;Immunoglobulin M;Immunology;immunoregulation;Immunosuppression;immunotoxicity;Impairment;Infection prevention;insight;Interferon Type II;Laboratory Animals;late life;Leukocytes;Life;Ligands;Link;Lymphocyte-Specific p56LCK Tyrosine Protein Kinase;Mediating;microbial;Modeling;Molecular;Molecular Probes;Mus;Nature;novel;pathogen;Phosphorylation;Phosphotransferases;physiologically based pharmacokinetics;Population;Predisposition;Production;programmed cell death protein 1;Protein Analysis;Protein Tyrosine Kinase;Proteins;Rattus;receptor;Receptor Activation;receptor expression;Refractory;remediation;Research;response;Risk Assessment;Role;Signal Transduction;single-cell RNA sequencing;Source;Steatohepatitis;T-Lymphocyte;Testing;Tetrachlorodibenzodioxin;Time;Toxic effect;transcriptome sequencing;Up-Regulation

PROJECT_TITLE: Project 1 - Dioxin-like Compounds Suppress IgM Responses by Targeting CD5+ (Innate-like) B cells, which can Serve as a Biomarker of Susceptibility to Environmental AHR Ligands


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Human Genome;Immunotherapy

ORG_CITY: ATLANTA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Program Narrative We have discovered a new complex regulatory element called the DR/DQ-super enhancer (DR/DQ-SE) that regulates the expression of the major histocompatibility complex class-II (MHC-II) proteins, which are critical for initiating and sustaining immune responses associated with a significant number of human diseases including infection, autoimmunity, and cancer. Here, we seek to elucidate the molecular and biochemical properties of the DR/DQ-SE and determine how and when it functions. Completion of our studies will shed new insight into how genes are organized and regulated, human variation impacts immunity, as well as how the immune system could be manipulated for control of many diseases and improved immunization.

PI_NAMEs: BOSS, JEREMY M. (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: 3-Dimensional;adaptive immune response;adaptive immunity;Address;Affect;Allogenic;Antigen-Presenting Cells;Antigens;Architecture;ATAC-seq;Autoimmune Diseases;Autoimmunity;B cell differentiation;B-Cell Development;B-Lymphocytes;base;Binding;Binding Proteins;Biochemical;Bioinformatics;Biological Assay;CD4 Positive T Lymphocytes;cell type;Cells;Chromatin;Chromatin Loop;chromatin remodeling;Chromatin Structure;Chromosome 6;chromosome conformation capture;cohesin;Communicable Diseases;Complex;CREB1 gene;CRISPR/Cas technology;cytokine;Data;design;Development;Disease;Elements;Enhancers;experimental study;Future;gene editing technology;Gene Expression;Gene Expression Regulation;gene function;Gene Structure;Genes;Genetic Polymorphism;Genetic Transcription;Goals;Helper-Inducer T-Lymphocyte;Histocompatibility Antigens Class II;histone modification;HLA-DQA1;HLA-DR Antigens;HLA-DRB1;Human;human disease;Human Genome;Immune;Immune response;Immune system;Immune System Diseases;Immunity;Immunization;Immunotherapy;improved;Individual;Infection;infectious disease treatment;insight;Insulator Elements;Interferon Type II;Knowledge;Link;Literature;Malignant Neoplasms;Mediating;Messenger RNA;MHC Class II Genes;MHC class II transactivator protein;Modeling;Molecular;novel;Nucleic Acid Regulatory Sequences;Peptides;Plasma Cells;Process;programs;promoter;Promoter Regions;Property;Proteins;recruit;Regulation;Regulatory Element;Regulatory T-Lymphocyte;Reporter Genes;Research;Role;Science;Series;stem;Structure;System;T cell response;T-Cell Activation;T-Lymphocyte;Technology;Testing;Therapeutic;Tissues;transcription factor;Transcriptional Regulation;transcriptome sequencing;Transplantation;Untranslated RNA;Vaccination;Variant;Work

PROJECT_TITLE: Role of the DR/DQ super enhancer in MHC-II expression

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative A person’s daily life events are linked by semantic and causal relations into a complex network; the proposed studies examine how human memory and its underlying cortical dynamics are influenced by the structure of these “event networks”, as well as what changes when people choose what they want to do and learn, as opposed to being passive observers. These factors are relevant to mental health: for example, cause-effect beliefs are strikingly disordered in schizophrenia. Achieving an improved understanding of how the brain encodes real-world events, and reconstructs them from memory when needed, will ultimately help guide the development of better treatments.

PI_NAMEs: CHEN, JANICE  (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Attention;Behavior;behavior influence;Belief;Brain;brain behavior;Child;Collection;Complex;Corpus striatum structure;Crowding;Data;Decision Making;Development;Dimensions;Disease;Environment;Event;experience;experimental study;Fever;Functional Magnetic Resonance Imaging;Goals;Graph;Higher Order Chromatin Structure;Hippocampus;Home;Hour;Human;improved;innovation;Internet;Judgment;Laboratory Finding;Learning;Life;Link;Location;Machine Learning;Measures;Memory;memory encoding;memory process;memory retrieval;Mental Health;Modeling;movie;musician;neural;neural correlate;neuromechanism;novel;Organism;Participant;Pattern;Persons;Prevalence;Property;real world application;reconstruction;Research;Research Personnel;Role;Schizophrenia;Semantics;Services;Shapes;Stimulus;Stream;Structure;System;Techniques;Telephone;Testing;Time;tool;Visit;Volition;Work

PROJECT_TITLE: Event networks and the neural representations that support real-world memory

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Agent Orange & Dioxin;Bioengineering;Endocrine Disruptors;Prevention

PHR: PROJECT NARRATIVE Thyroid hormones regulate cellular energy metabolism throughout the body and chemical disruption of this function in humans causes neurological, hearing, and vision dysfunction in children, as well as metabolic disorders and cancer in adults. Due to the complex nature of the thyroid system, the way many Superfund chemicals disrupt thyroid function is unclear. We propose to bioengineer thyroid and liver microtissues and use them along with computational modelling to understand how these chemicals cause toxicity, test chemicals and their mixtures for their ability to disrupt thyroid signaling, and translate our findings to determine how chemical exposures might affect human populations.

PI_NAMEs: JOHNSON, BRIAN P. (contact)

PROJECT_TERMS: Adult;adverse outcome;Affect;Androgens;Animal Model;Animals;Area;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Binding;Biological Assay;Biological Markers;Biological Models;Biomedical Engineering;Catabolism;Cells;Chemical Actions;Chemical Exposure;Chemicals;Child;Communities;Complex;Computer Models;Coupling;Data;deiodination;Development;dibenzo(1,4)dioxin;dibenzofuran;Dioxins;Dose;energy balance;Energy Metabolism;Engineering;Estrogens;Event;Exhibits;Feedback;Functional disorder;Glucuronides;Health;Hearing;Hepatic;Hepatocyte;Homeostasis;Hormone imbalance;Hormones;Human;hypothalamic-pituitary-thyroid axis;Image;improved;in silico;In Vitro;Industrial Accidents;inhibitor;Intervention;Italy;Kinetics;Life;Link;Liver;Malignant Neoplasms;Mediating;Metabolic Diseases;Metabolism;microbial;microphysiology system;Modeling;Molecular;Molecular Target;Mus;National Health and Nutrition Examination Survey;Nature;Neurodevelopmental Deficit;Neurologic;novel;offspring;Outcome;Pathway interactions;pharmacokinetic model;Physiological;physiologically based pharmacokinetics;Play;Population;population health;Populations at Risk;Predisposition;prevent;Production;prototype;Rattus;receptor;Receptor Activation;Recycling;Research;response;Risk;Risk Assessment;Rodent Model;Role;screening;Serum;Signal Recognition Particle;Signal Transduction;Sulfate;Superfund;superfund chemical;synergism;System;Testing;thyroid disruption;Thyroid Function Tests;Thyroid Gland;Thyroid Hormones;Thyrotropin;Tissues;Toxic effect;Translating;Vision;Woman

PROJECT_TITLE: Project 2 - Coupling Bioengineered and Computational Models of Thyroid Homeostasis to Support Human PCDD/F Risk-Assessment


ORG_CITY: RICHMOND

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Mutations of the p53 gene are common in lung cancer. We have developed a viral therapy that specifically kills lung cancer cells with mutant p53 while having no effect on normal cells. We propose to develop innovative therapeutic strategies for treating lung cancer based on this technology.

PI_NAMEs: DEB, SUMITRA  (contact);WINDLE, BRAD E.

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Acceleration;Adenovirus Vector;Adenoviruses;Affect;Alleles;Amino Acids;Automobile Driving;Base Sequence;Biological Assay;Biological Models;Bystander Effect;cancer cell;Cell Death;cell type;Cells;Cessation of life;Cloning;Cytolysis;Cytomegalovirus;Cytosine deaminase;DNA Sequence;Early Promoters;Exposure to;gain of function;Ganciclovir;Gene Activation;gene cloning;Gene Expression;Gene Proteins;Genes;Goals;Growth;Herpesvirus 1;Human;improved;individual response;innovation;Lung;lung cancer cell;Lung Neoplasms;Lytic;Lytic Phase;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Modeling;mouse model;Mus;mutant;Mutation;Mutation Analysis;Normal Cell;novel;null mutation;Oncogenic;Oncogenic Viruses;oncolysis;Oncolytic;oncolytic adenovirus;Oncolytic viruses;patient derived xenograft model;Phenotype;Process;Prodrugs;promoter;Property;Proteins;Reporter;Research;response;Response Elements;Specificity;Suicide;suicide gene;suicide virus;System;targeted treatment;Technology;Testing;Therapeutic;therapeutic target;Thymidine Kinase;thymidine kinase 1;Time;TP53 gene;Transactivation;tumor;tumor xenograft;vector;Viral;Virus;Virus Replication;weapons;Work;Xenograft procedure

PROJECT_TITLE: Targeting lung tumors expressing mutant p53 with oncolytic viruses and suicide genes

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


NIH_SPENDING_CATS: Agent Orange & Dioxin;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Endocrine Disruptors;Liver Disease;Nutrition

PHR: PROJECT NARRATIVE The aryl hydrocarbon receptor (AhR) is a sensor protein for environmental pollutants such as 2,3,7,8- tetrachlorodibenzo-p-dioxin and related compounds. These chemicals have been linked to adverse outcomes, including non-alcoholic fatty liver disease (NAFLD) and this project will investigate the link between AhR activation and changes in cholesterol homeostasis in TCDD elicited hepatotoxicity and the progression of NAFLD. Given that ~20 million Americans suffer from NAFLD, investigating the link between AhR activation and the progression of NAFLD is of national importance.

PROJECT_TERMS: 3-hydroxy-3-methylglutaryl-coenzyme A;Adult;adverse outcome;Affect;American;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Bay Region;Body Burden;carbohydrate metabolism;Cells;Chemicals;Cholesterol;cholesterol biosynthesis;Cholesterol Homeostasis;Coenzyme A;Collaborations;Computer Models;cytotoxicity;Data;Development;Diabetes Mellitus;Diet;dietary;Dioxins;Disease Progression;Dose;Environmental Exposure;Environmental Pollutants;Epidemic;Epidemiology;experience;experimental study;exposed human population;Exposure to;Fatty Liver;Fibrosis;Flow Cytometry;Gene Expression;genome analysis;Hepatic;Hepatocyte;Hepatotoxicity;Homeostasis;Human;hypercholesterolemia;hypocholesterolemia;immune cell infiltrate;In Vitro;Individual;Investigation;Knock-out;Link;lipid metabolism;Lipid Peroxidation;Lipids;Low-Density Lipoproteins;Mediating;Metabolic;Metabolic dysfunction;Metabolism;mevalonate;microbial;Mitochondria;Modeling;Mus;non-alcoholic fatty liver disease;Nonesterified Fatty Acids;Obesity;Oxidative Stress;Oxidoreductase;Pathogenesis;Pharmaceutical Preparations;Play;Population;Proteins;Receptor Activation;Repression;response;Risk;Risk Assessment;Rodent;Role;sensor;Serum;Signal Transduction;Simvastatin;single nucleus RNA-sequencing;Steatohepatitis;Structure;Testing;Tetrachlorodibenzodioxin;Toxic effect

PROJECT_TITLE: Project 3 - The role of HMGCR in Modulating TCDD-induced, AHR-mediated NAFLD


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE  Prostate cancer patients on drugs that block testosterone action ultimately become resistant to therapy and follow a downhill course with poor outcomes. One mechanism of resistance is a process called lineage plasticity, in which cancerous cells acquire a new identity. In this proposal, we will use complementary biological and computational tools to determine how exactly cells become plastic and resistant to drugs.

PI_NAMEs: ZAIDI, SAMIR  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Adenocarcinoma;Advisory Committees;androgen independent prostate cancer;Androgen Receptor;ATAC-seq;Biological;Biopsy;BRAF gene;cancer cell;Cancer Model;Cancer Patient;Cancerous;Cells;Chemicals;Clinical;Collaborations;Combined Modality Therapy;Competence;computerized tools;CRISPR/Cas technology;Data;DNA;Doxycycline;Drug Combinations;Drug resistance;efficacy evaluation;Environment;enzalutamide;Epidermal Growth Factor Receptor;Estrogen receptor positive;Event;Evolution;FDA approved;FGFR1 gene;FGFR3 gene;Fibroblast Growth Factor Receptors;Funding;Future;Gene Modified;Genetic;Genetic Models for Cancer;Genitourinary system;Genomics;Goals;Grant;Histology;Human;in vivo;inhibitor;Kinetics;Knockout Mice;Lead;Lung;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;MAP Kinase Gene;Mediating;Melanoma;Memorial Sloan-Kettering Cancer Center;Mentors;Modeling;Molecular;Morphology;mouse model;multiple omics;Mus;mutant;Neurosecretory Systems;NOD/SCID mouse;novel;Oncogenic;Oncology;Organoids;Outcome;overexpression;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Physicians;PIK3CG gene;Positioning Attribute;Predictive Factor;Process;programs;Prostate;Protein Isoforms;Proto-Oncogene Proteins c-akt;Randomized;RB1 gene;receptor expression;Receptor Signaling;Research;Research Personnel;Resistance;resistance mechanism;Resources;RNA;Safety;Sampling;Science;Signal Pathway;Signal Transduction;single-cell RNA sequencing;STAT1 gene;STAT3 gene;subcutaneous;success;synergism;targeted agent;targeted cancer therapy;Testosterone;Therapeutic;therapy resistant;Time;TP53 gene;Training;transcription factor;transcriptome sequencing;Translations;Transplantation;tumor;Tumor Suppressor Genes;Tumor Weights;XCL1 gene

PROJECT_TITLE: Studies on Lineage Plasticity in Prostate Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Agent Orange & Dioxin;Endocrine Disruptors

PHR: PROJECT NARRATIVE Some anaerobic bacteria are capable of breathing dioxins. We aim to leverage this capability to develop integrated methods for economical clean-up of dioxin-contaminated sites. Key advancements include reduction in time to clean-up and toxicity, development of biomarkers indicative of the rates, and establishment of decision- making tools.

PI_NAMEs: HASHSHAM, SYED A. (contact)

PROJECT_TITLE: Project 4 - Design Principles and Field-Deployable Models for Economical Remediation of Dioxin-Contaminated Sites


PHR: PROJECT NARRATIVE Project 5 directly addresses NIEHS Superfund Mandate #4 for the development of “basic biological, chemical, and physical methods to reduce the amount and toxicity of hazardous substances” [22]. Project 5 will help USEPA understand whether activated carbon (AC) is an effective soil/sediment amendment to sequester PCDD/Fs in forms that eliminate their mammalian bioavailability and toxicity, and thus protect human and ecosystem health. Project 5 will test a cause-and-effect relationship for the rates at which AC can reduce or eliminate mammalian bioavailability by measuring a multi-year time series for a) the rates at which AC amendments accumulate PCDD/Fs and b) the mammalian bioavailabilities of PCDD/Fs from these same soils.

PI_NAMEs: TEPPEN, BRIAN JOHN (contact)

PROJECT_TERMS: Address;Adopted;Age;aged;Amendment;aryl hydrocarbon receptor ligand;Binding;Biological;Biological Availability;Carbon;Charcoal;Chemicals;clay;Collaborations;Complex;Computer Models;Corn Oil;cost;Data;Decision Making;design;Development;dibenzo(1,4)dioxin;Dose;Ecosystem;Environment;Environmental Impact;Equilibrium;evidence base;Experimental Designs;Furans;Goals;Hazardous Substances;Hazardous Waste;Health;Human;improved;In Situ;Individual;Kinetics;landfill;Literature;Mammals;Mass Fragmentography;Measurement;Measures;Methods;microbial;Minerals;Modeling;Mus;National Institute of Environmental Health Sciences;Oral;particle;Porosity;prevent;Procedures;Process;Property;Protocols documentation;remediation;Research;response;Rest;Risk Assessment;Role;Sampling;Science;Series;Signal Recognition Particle;Silicon Dioxide;Site;Soil;Solid;Structure;Superfund;superfund site;System;Testing;Tetrachlorodibenzodioxin;Time;Toxic effect;United States Environmental Protection Agency;Water;water solubility;Work

PROJECT_TITLE: Project 5 - Bioavailability as a Central Concept in Determining Remediation Goals and Strategies for PCDD/F-Contaminated Superfund Sites


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: KANSAS CITY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: NARRATIVE The present proposal is directed to develop a non-hormonal agent that could be used as an oral and reversible contraceptive for males. The goals of the project are: 1) to develop a lead and a backup compound that can selectively inhibit the sperm specific NKAα4 to block sperm function, and that will be ready for testing on mice; and 2) to perform preclinical investigational new drug (IND)-enabling studies, which will allow moving these compounds forward for their use as male contraceptives.

PI_NAMEs: BLANCO, V GUSTAVO (contact);GEORG, GUNDA I.

PROGRAM_OFFICER_NAME: KAUFMAN, STEVEN

PROJECT_TERMS: absorption;Affect;Affinity;analog;Animals;Antihistamines;Appearance;Area;Binding;Binding Proteins;Biochemical;Biological;Biological Availability;Biological Markers;birth control;Cell membrane;Cells;Characteristics;Chemicals;Clinical;Clinical Research;Contraceptive Agents;Contraceptive methods;Cytoplasm;Data;Drug Kinetics;Drug Targeting;druggable target;Effectiveness;efficacy study;Ejaculation;Epididymis;Ethers;experimental study;extracellular;Female;female reproductive tract;Fertility;Fertilization in Vitro;Future;Gland;Goals;Human;Hyperactivity;improved;in silico;In Vitro;in vivo;Infertility;inhibitor;Investigational Drugs;Ions;Knockout Mice;Lead;male;Male Contraceptive Agents;male fertility;Male Infertility;Maximum Tolerated Dose;Meiosis;Membrane Potentials;men;Metabolic;Metabolism;molecular size;monolayer;Motility;Mus;Mutation;novel;Oral;Oral Administration;Oral Contraceptives;Ouabain;Partner in relationship;Permeability;Pharmaceutical Chemistry;pharmacologic;Pilot Projects;Plasma;Population;pre-clinical;preclinical study;progenitor;programs;Property;Protein Isoforms;Proteins;Public Health;Research;reversible contraceptive;Safety;scaffold;scale up;Series;side effect;Site;small molecule;Solubility;Source;Specificity;Sperm Capacitation;sperm cell;sperm function;Sperm Motility;Sperm Tail;Spermatocytes;Spermatogenesis;Sterility;Surface;System;Testing;Testis;Toxic effect;unintended pregnancy;Validation;virtual screening;Woman

PROJECT_TITLE: Targeting Na,K-ATPase alpha4 for male contraception

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Disability Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

PHR: PROJECT NARRATIVE Representing ~3% of the U.S. population, non-elderly disabled Medicare beneficiaries (henceforth “disabled beneficiaries”) account for ~25% of overdose deaths and hospitalizations related to prescription opioids. To identify overprescribing without directly restricting patient access, the U.S. Centers for Medicare and Medicaid Services (CMS) required Medicare Part D plans to incorporate a set of opioid safety edits into their drug utilization review systems, effective January 1, 2019. Our project seeks to inform policymakers about the implications of the 2019 Medicare Part D safety policy for an understudied, high-risk population of disabled beneficiaries who are prescribed long-term, high-dose opioid therapy, which will further enable policymakers to develop clinically and culturally nuanced policies and practices tailored to the disabled population, the racial/ethnic minority patients and rural patients, and the evolving pandemic/post-pandemic environment.

PI_NAMEs: WEN, HEFEI  (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Accident and Emergency department;Adverse event;Age;American;Authorization documentation;beneficiary;Buprenorphine;care coordination;Caring;chronic pain;Clinical;cohort;Consult;Consultations;Coupled;COVID-19;COVID-19 pandemic;Data;disability;disabled;Disabled Persons;Disabling condition;Disparity;Dose;Drug Utilization Review;Emergency Situation;Ensure;Environment;ethnic minority;Ethnic Origin;Federal Government;fighting;flexibility;Healthcare;high risk;high risk population;Hospitalization;implicit bias;Improve Access;Inpatients;Intellectual functioning disability;interest;Intervention;Medical;medically underserved;Medicare;Medicare claim;Mental disorders;milligram;minority patient;Morphine;mortality;Musculoskeletal Diseases;Opioid;opioid epidemic;opioid tapering;opioid therapy;opioid use disorder;overdose death;pandemic disease;Patients;Pharmaceutical Preparations;Pharmacists;Play;Policies;Policy Maker;Population;post intervention;post-pandemic;pre-pandemic;Predisposition;prescription opioid;Quasi-experiment;Race;racial minority;Regulation;response;Rural;Rural Community;rural patients;Safety;Signal Transduction;System;tele-evaluation;telehealth;United States Centers for Medicare and Medicaid Services

PROJECT_TITLE: Impact of Medicare Part D opioid safety policies on disabled beneficiaries before and during the COVID-19 pandemic

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


PHR: PROJECT NARRATIVE The Administrative Core provides support for the research, training, community engagement, data management and information and technology transfer in this Center Program. The Core will take leadership for regular communication with Center investigators and NIEHS for exchange of information, prepare progress reports, fiscal responsibility, technology transfer and communication with stakeholders in government, academia and industry regarding the research program.

PROJECT_TERMS: Academia;Accountability;Administrator;Advisory Committees;aryl hydrocarbon receptor ligand;Budgets;Center for Translational Science Activities;Communication;community engagement;data management;Decision Making;environmental toxicology;Exercise;Expenditure;Funding;Government;Government Agencies;Government Officials;Human Resources;individual responsibility;Industry;Institution;Lead;Leadership;meetings;Michigan;microbial;Molecular Toxicology;Monitor;multidisciplinary;National Institute of Environmental Health Sciences;operation;organizational structure;Pilot Projects;Preparation;Principal Investigator;Process;programs;Progress Reports;Reporting;Research;Research Personnel;Research Project Grants;Research Support;response;Schedule;Specialist;Structure;Superfund;Technology Transfer;Time;Toxicology;Training;Translational Research;Universities;Update;Videoconferencing;web site

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Regenerative Medicine

ORG_CITY: Aurora

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The goal of this training program is to train a diverse group of scientists to solve problems relevant to human health, including developmental diseases. Predoctoral students will learn to responsibly conduct research in genetics, developmental, cell and stem cell biology and gain important communication and professional skills.

PI_NAMEs: APPEL, BRUCE H;MOORE, JEFFREY KYLE (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TITLE: Predoctoral Training in the Genetics of Development, Disease and Regeneration

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD)

PHR: PROJECT NARRATIVE The MSU SRC Data Management and Analysis Core (DMAC) will support effective data management and data science-based analysis through the implementation of a comprehensive data management and analysis plan. This will involve: 1) facilitating coordination between projects and cores to foster data science approaches for identifying new associations within disparate data that lead to the formation of new hypotheses, 2) enabling data sharing between MSU SRC projects and cores, as well as external stakeholders, and interoperability with external repositories, 3) implementing data quality assurance and quality control procedures and processes, and 4) providing center-wide training regarding data management and analysis principles.

PI_NAMEs: KASTEN, ERIC P. (contact)

PROJECT_TERMS: Acceleration;Archives;aryl hydrocarbon receptor ligand;Biological Assay;central database;Certification;Collaborations;Collection;computerized tools;computing resources;Consensus;Consultations;Controlled Environment;Data;Data Analyses;Data Collection;Data Commons;Data Coordinating Center;data exploration;data integration;data integrity;data interoperability;data management;data modeling;data quality;Data Science;Data Set;data sharing;data standards;Deposition;Development;Disparate;Education;education resources;Educational workshop;Elements;Ensure;Environment;experience;Exposure to;FAIR principles;Fostering;Funding;Goals;implementation science;Infrastructure;interoperability;Investigation;Investments;Knowledge;Life Cycle Stages;Mentors;Metadata;Michigan;microbial;Monitor;Online Systems;Ontology;open source;Play;Population;Practice Management;Privatization;Procedures;Process;programs;Protocols documentation;Publishing;quality assurance;Quality Control;Reporting;repository;Reproducibility;Reproducibility of Results;Reproduction;Research;Research Personnel;research to practice;Resources;response;Standardization;Superfund;tool;Training;Training Activity;Training and Education;Translational Research;Universities;Visualization;Work

PROJECT_TITLE: Data Management and Analysis Core


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE The Postgraduate Training Program in Medical Imaging (PTPMI) addresses unmet needs in medical imaging technology as it pertains to normal and pathophysiological functions in a unique multi-institutional research environment at MGH, HMS and MIT. The PTPMI provides a multidisciplinary approach to training with customized, diverse mentoring with exciting research opportunities for the new generation of diverse imaging scientists. Outcomes from the previous period are exceptionally strong both in terms of diversity and inclusion as well as scholarship and career success in biomedical areas directly related to NIBIB priorities.

PI_NAMEs: CATANA, CIPRIAN  (contact);HEIDARI, PEDRAM

PROGRAM_OFFICER_NAME: ERIM, ZEYNEP

PROJECT_TERMS: Medical Imaging;Training Programs


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Rural Health;Social Determinants of Health

PHR: PROJECT NARRATIVE We propose to expand our existing close collaboration with the Michigan Department of Health and Human Services through a novel set of engagement activities that will listen to three Michigan communities affected by dioxins, empower them to make informed prevention decisions through health education interventions, and evaluate the impacts of those engagements. We will innovate on our previous work by leveraging the state of the science on trust, risk, and community engagement to optimally position the engagements to build trusting relationships between the Department and Michigan communities. We also propose to disseminate what we learn to our wider Center and the entire Superfund Research Program to better position them to build trust with the various individuals and groups impacted by their work.

PI_NAMEs: HAMM, JOSEPH  (contact)

PROJECT_TERMS: Address;Affect;aryl hydrocarbon receptor ligand;Collaborations;Communication;Communities;community building;community engagement;County;Data;design;Dioxins;Educational Intervention;Educational workshop;Elements;empowerment;Ensure;Environmental Health;Evaluation;Event;experience;Fostering;Funding;Goals;Hazardous Substances;Health;Health education;Health Surveys;improved;Individual;Information Dissemination;innovation;Knowledge;Learning;learning community;member;Methodology;Michigan;microbial;novel;Play;Politics;Positioning Attribute;Postdoctoral Fellow;Prevention;Process;Productivity;programs;Publications;Research;Research Personnel;resilience;Resources;response;Risk;Role;Running;Rural Community;Science;Series;Signal Recognition Particle;Social Environment;Students;suburb;Superfund;Toxic effect;Training;Translational Research;Trust;United States Dept. of Health and Human Services;Urban Community;vulnerable community;Work

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Orphan Drug;Precision Medicine;Rare Diseases

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Role of BCL10 somatic mutations in lymphomagenesis and response to BCR-targeted therapies PROJECT NARRATIVE: C1/BN2 lymphomas, a newly discovered aggressive lymphoma, are characterized by somatic mutations in the BCL10 gene, which are rare in other lymphoma subtypes. Elucidation of the structural, biochemical and functional changes induced by BCL10 somatic mutations will advance our knowledge of the underlying molecular mechanisms by which different BCL10 mutations drive lymphomagenesis and inform the design and preclinical development of new treatment strategies.

PI_NAMEs: CERCHIETTI, LEANDRO C (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Acceleration;Affect;Agreement;Antigens;Automobile Driving;B-Cell Activation;B-Cell Antigen Receptor;B-Cell Development;B-Cell NonHodgkins Lymphoma;B-Lymphocytes;BCL1 Oncogene;BCL10 gene;BCL6 gene;BCR Signaling Pathway;Binding;Biochemical;Biological;Biology;Bypass;C-terminal;Categories;cell growth;Cell Line;Cell Survival;Classification;Clinic;Complex;Crystallization;Data;design;Development;Disease;Docking;Drug Targeting;gain of function;gain of function mutation;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;genetic profiling;Genetic Transcription;genomic profiling;Genomics;Goals;Higher Order Chromatin Structure;improved;In Vitro;in vivo;Induced Mutation;inhibitor;kinase inhibitor;Knowledge;large cell Diffuse non-Hodgkin's lymphoma;Lymphoma;Lymphomagenesis;Malignant - descriptor;Malignant lymphoid neoplasm;Mediating;Missense Mutation;Molecular;Molecular Structure;molecular subtypes;Mucosa- associated lymphoid tissue lymphoma translocation protein-1;mutant;Mutation;NF-kappa B;novel;novel therapeutic intervention;Oncogenes;overexpression;p65;Pathway interactions;Patients;Peptide Hydrolases;polymerization;Polymers;precision medicine;preclinical development;Proliferating;Proteins;Proto-Oncogenes;recruit;Regimen;Resistance;response;Rest;Role;Series;Set protein;Signal Pathway;Signal Transduction;Somatic Mutation;Structure;targeted treatment;Therapeutic;Toll-like receptors;tumor


ED_INST_TYPE: SCHOOLS OF LAW OR CRIMINOLOGY

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Title: Transdisciplinary Training at the Intersection of Environmental Health and Social Science Project Narrative: This renewal of the successful “Transdisciplinary Training at the Intersection of Environmental Health and Social Science” prepares 10 doctoral students and 8 postdocs to be future leaders in social science-environmental health science collaborations. This training program is uniquely co-directed by an academic institution - Northeastern University and a non-academic institution - Silent Spring Institute, a science-based/community-based participatory research environmental non-profit organization. Trainees will have coursework and skills sessions at NU, research projects at both NU and Silent Spring Institute, and visits to laboratories and community groups.

PI_NAMEs: BRODY, JULIA GREEN;BROWN, PHILIP M. (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TITLE: Transdisciplinary Training at the Intersection of Environmental Health Science and Social Science (EH+SS)

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(T)]


PHR: PROJECT NARRATIVE The Research Experience and Training and Coordination Core (RETCC) will be the innovative and coordinating hub that facilitates the Michigan State University Superfund Research Center’s (MSU SRC) aim to provide multi- method, interdisciplinary training to predoctoral and postdoctoral students through research collaborations across biomedical and non-biomedical research projects as well as the Community Engagement Core, Data Management and Analysis Core and the Administrative Core’s Research Translation functions.

PI_NAMEs: BERNARD, JAMIE J (contact)

PROJECT_TERMS: Acceleration;aryl hydrocarbon receptor ligand;Atmosphere;Biochemistry;Biological Sciences;Biology;Collaborations;Communication;Communities;community engagement;community research;Computational Biology;coronavirus pandemic;Creativeness;Data;Data Analyses;data management;design;Dimensions;Discipline;doctoral student;E-learning;educational atmosphere;Educational process of instructing;Engineering;Environmental Health;Environmental Pollutants;experience;Faculty;Genomics;graduate student;Health;Historically Black Colleges and Universities;Hour;Individual;informal learning;Informatics;Information Systems;innovation;insight;Instruction;Interdisciplinary Study;Joints;Journals;Laboratories;Learning;Link;Mathematics;meetings;member;Methods;Michigan;microbial;Modeling;Molecular Biology;Motivation;Movement;National Institute of Environmental Health Sciences;outreach;paragon;pharmacokinetic model;Pharmacology;physical science;Physiological;Postdoctoral Fellow;pre-doctoral;Procedures;Publications;recruit;Research;Research Personnel;Research Project Grants;response;Risk;risk perception;Rivers;Running;Science;Series;Signal Recognition Particle;social;Social Sciences;Soil;Special Education;student training;Students;success;Superfund;symposium;System;Systems Biology;Techniques;Thinking;Time;Toxicokinetics;Toxicology;Training;Translational Research;translational scientist;Travel;Uncertainty;undergraduate research experience;Underrepresented Minority;United States National Institutes of Health;Universities;Videoconferencing;virtual;virtual laboratory;Visit

PROJECT_TITLE: Research Experience and Training Coordination Core


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative This proposal is relevant to public health and cancer prevention because it will provide comprehensive data on the influence of Facebook food advertisements on Black and White adolescents' eating behaviors, and increase mechanistic knowledge of communication strategies that influence the number of calories purchased and consumed by adolescents. Once such knowledge is gained, there is potential for significant advances in the development of interventions seeking to establish lifelong cancer-prevention dietary habits among adolescents. The project is relevant to the mission of the National Cancer Institute because it aims to identify factors in the new media ecosystem that may contribute to behaviors that increase risk for diet-related cancers, and it provides a new framework for understanding how the participatory social media ecosystem affects cancer prevention behaviors among youth who are targeted with unhealthy food and beverage advertisements.

PI_NAMEs: BRAGG, MARIE  (contact)

PROGRAM_OFFICER_NAME: ILES, IRINA ALEXANDRA

PROJECT_TERMS: 12 year old;17 year old;Academy;Address;Adolescence;Adolescent;Adopted;Adult;Advertisements;Advertising;Affect;Age;Behavior;Beverages;Black Populations;Black race;Calories;cancer prevention;Cancer Prevention Intervention;Child;Colon Carcinoma;Communication;Communication Tools;Computers;Consumption;critical period;Data;Diet;Diet Habits;dietary;Disparity;Eating Behavior;Ecosystem;Energy Intake;Expenditure;experimental study;Exposure to;Face;Facebook;Food;food marketing;frontier;Future;Health;high risk;Hour;Household;improved;Income;innovation;Intake;Intervention Studies;Knowledge;laboratory experiment;Lead;Life;Link;Low income;Malignant neoplasm of liver;Malignant Neoplasms;media use;Medicine;Mission;National Cancer Institute;neural;novel;Nucleus Accumbens;Nutritional;Obesity;Overweight;overweight child;Patient Self-Report;peer;Persons;Policies;preference;Prevalence;prevent;primary outcome;Privacy;psychologic;Public Health;Race;Randomized;Randomized, Controlled Trials;Reaction;Renal Carcinoma;Reporting;Research;Rewards;Risk;Risk Factors;Sampling;secondary outcome;social media;Surveys;Techniques;Technology;Television;Testing;therapy development;Time;tool;tv watching;Unhealthy Diet;United States;Update;Visual;Visual attention;visual tracking;Weight;Weight Gain;willingness;Work;Youth

PROJECT_TITLE: Examining the Mechanisms Underlying the Influence of Facebook Food Advertisements on Adolescents' Eating Behaviors: Randomized Controlled Trials


NIH_SPENDING_CATS: Agent Orange & Dioxin;Bioengineering;Digestive Diseases;Endocrine Disruptors;Liver Disease;Networking and Information Technology R&D (NITRD);Prevention

PHR: PROJECT NARRATIVE By supporting multiple biomedical and environmental engineering projects, CMC develops a suite of innovative computational tools to help improve our understanding of the toxicological effects of dioxin on immunity, thyroid hormone homeostasis and lipid metabolism, and support health risk assessment of dioxin exposure.

PI_NAMEs: ZHANG, QIANG  (contact)

PROJECT_TERMS: Address;Adopted;adverse outcome;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;B-Lymphocytes;Bacteria;Binding Proteins;Bioinformatics;bioinformatics tool;Biological;Biological Availability;Biological Models;biological research;Biomedical Engineering;Bioremediations;Carbon;Cells;Cobalamin;Collaborations;Communities;Complex;computational suite;computational toxicology;Computer Models;computerized tools;CYP1A2 gene;Data;Data Set;Decision Making;dehalogenation;design;dibenzo(1,4)dioxin;Dioxins;Dose;dosimetry;dynamic system;Engineering;Environmental Engineering technology;Environmental Pollutants;environmental toxicology;Enzymes;Evaluation;Event;Exposure to;Fatty Liver;Feedback;Foundations;Furans;gene network;gene regulatory network;Generations;Genetic Complementation Test;Genetic Transcription;Health;Hepatic;Hepatocyte;Hepatotoxicity;high dimensionality;Homeostasis;hormone metabolism;Human;human model;hypothalamic-pituitary-thyroid axis;Immunity;Immunoglobulin M;Immunosuppression;immunotoxicity;improved;in silico;In Vitro;in vitro Assay;in vivo;Informatics;innovation;Investigation;laboratory experiment;Laboratory Study;large datasets;Link;lipid metabolism;Lipids;Liver;Mediating;Metabolic;Michigan;microbial;model development;Modeling;Molecular;multidimensional data;Mus;next generation;Nonlinear Dynamics;novel;novel marker;Organism;Outcome;Pathway interactions;pharmacodynamic model;Pharmacodynamics;pharmacokinetic model;pharmacokinetics and pharmacodynamics;Physiological;physiologically based pharmacokinetics;pollutant;Population;population health;predictive marker;Predisposition;Receptor Activation;Regimen;remediation;Research;Research Personnel;Research Support;Resolution;response;Risk Assessment;Role;Signal Recognition Particle;Signal Transduction Pathway;simulation;single-cell RNA sequencing;Soil;Spleen;Structure;Superfund;superfund site;support tools;System;Systems Analysis;Systems Theory;Techniques;Testing;thyroid disruption;Thyroid Hormones;Tissues;tool;Toxic effect;Toxicant exposure;Toxicology;Training;Transcription Alteration;Universities;university student;Vitamin B 12

PROJECT_TITLE: Computational Modeling Core


NIH_SPENDING_CATS: Mental Health;Neurosciences;Pediatric

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Our program focuses on preparing scientists, in both clinical and basic sciences, for independent careers as field-leading principal investigators, conducting research on childhood onset neuropsychiatric disorders. This training program will facilitate the development of a diverse and highly trained workforce of individuals from a variety of disciplines, many of whom will ultimately assume leadership roles, rising to meet the nation’s need to develop treatment and prevention programs to improve the lives of the large number of children affected by or at risk to develop major mental illnesses.

PI_NAMEs: BLOCH, MICHAEL H;CROWLEY, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TITLE: Training Program in Childhood Neuropsychiatric Disorders


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Lung;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Tuberculosis

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE: This project will clarify epigenetic mechanisms by which tuberculosis (TB) subverts immune homeostasis and increases the risk of post-TB mortality. The information gleaned will have practical applications, such as the identification of mechanisms and drugs that can reverse detrimental epigenetic scars, restore immune homeostasis, and decrease post-TB mortality. This information is necessary for the establishment of therapies to revive host immunity and thereby improving treatment efficacy and lowering TB mortality.

PI_NAMEs: DINARDO, ANDREW R (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Age;Animal Model;Antigens;Antimycobacterial Agents;Automobile Driving;Bioinformatics;Cardiovascular Diseases;Cavia;CD34 gene;CD8-Positive T-Lymphocytes;Cells;Cessation of life;Chronic;chronic infection;Cicatrix;Citric Acid Cycle;Clinical;clinically relevant;cofactor;cohort;Country;Cytomegalovirus;Data;Death Rate;Development;Diagnosis;DNA;DNA Methylation;Enrollment;Enzymes;epigenetic aging;Epigenetic Process;epigenomics;exhaust;Gene Expression;Genes;Glean;guinea pig model;Hematopoietic stem cells;HIV;Homeostasis;Human;Hypermethylation;Immune;immune function;Immune Tolerance;Immunity;Immunosuppression;improved;In Vitro;in vivo;Infection;Inflammation;Inflammatory;inhibitor;Interferons;Interleukin-6;Intervention;Knowledge;Life;Link;Lymphocytic choriomeningitis virus;Malignant Neoplasms;Measures;Mediating;Metabolic Pathway;Metformin;Methylation;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;mycobacterial;Outcome;Pathologic;Pathway interactions;patient retention;Patients;Persons;Pharmaceutical Preparations;Phase II Clinical Trials;Population;practical application;premature;Principal Component Analysis;progenitor;Publications;Recurrence;Resources;Risk;Schistosomiasis;SDZ RAD;sex;Signal Pathway;stem cells;Succinates;support vector machine;Survivors;T-Lymphocyte;Techniques;Testing;TNF gene;transcriptome sequencing;Translating;Translational Research;Treatment Efficacy;Tricarboxylic Acids;Tuberculosis;tuberculosis treatment;Work

PROJECT_TITLE: Post-TB epigenetic scars' impact on long-term inflammation, immunity and mortality

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


ADMINISTERING_IC: NS

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative The predoctoral Neuroscience Training Program at the University of California, Berkeley seeks to educate future leaders in neuroscience research by providing broad neuroscience training from molecules to mind, including both basic and disease-related research, with a major focus on advanced methods. Our program combines flexible coursework, rigorous research training, substantial quantitative and professional skills training, and supportive advising. Our goal is to fuel paradigm shifts in how we study the brain, and to educate scientists who can translate basic discoveries into solutions for human neurological diseases.

PI_NAMEs: BATEUP, HELEN S. (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Neurosciences;Training Programs

PROJECT_TITLE: Neuroscience Training Program at UC Berkeley


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cancer;Clinical Research;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Narrative We develop a strategy to combine ultrasound with agonist CD40 with toll like receptor agonist R848 for the treatment of pancreatic cancer.

PI_NAMEs: FERRARA, KATHERINE W (contact)

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: Ablation;Abraxane;Address;Agonist;Animals;anti-CTLA4;anti-PD-1;Antibodies;Antibody Therapy;Biological Assay;Cell Maturation;Cell model;Cells;Characteristics;checkpoint inhibition;checkpoint therapy;chemotherapy;Clinical Research;clinically relevant;cohort;Combination immunotherapy;Data;Dendritic Cells;Distant;Dose;Dose Limiting;Flow Cytometry;Focused Ultrasound;Focused Ultrasound Therapy;Future;gastrointestinal;gemcitabine;Head and Neck Cancer;Human;Hyperthermia;imaging modality;imaging probe;Immune;Immune checkpoint inhibitor;Immune response;Immunotherapy;Implant;improved;in situ vaccination;intravenous injection;KPC model;Liposomes;Lymphocyte;Lymphoma;Macrophage;Magnetic Resonance;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Methods;Molecular;Monitor;Monoclonal Antibodies;mouse model;Mus;Myeloid-derived suppressor cells;neoplastic cell;Pancreas;pancreatic cancer cells;pancreatic cancer model;Pancreatic Ductal Adenocarcinoma;pancreatic neoplasm;patient derived xenograft model;Patients;Penetration;Pharmaceutical Preparations;Phenotype;porcine model;Positron-Emission Tomography;Proliferating;Protocols documentation;receptor;Regulatory T-Lymphocyte;resiquimod;response;Safety;Schedule;single cell analysis;Site;synergism;systemic toxicity;T-Cell Activation;T-cell inflamed;Temperature;Testing;Therapeutic;TLR7 gene;TNFRSF5 gene;Toll-like receptors;Toxic effect;transcriptome sequencing;Translating;Translations;Treatment Protocols;tumor;tumor ablation;Tumor Antigens;Tumor Volume;ultrasound;ultrasound ablation;Vascular blood supply;Work

PROJECT_TITLE: HIFU-immunotherapy in pancreatic cancer

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Clinical Research;Eczema / Atopic Dermatitis;Microbiome

ORG_CITY: SAN FRANCISCO

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Many human skin diseases are thought to result from abnormal immune cells that reside in diseased organs. Experiments in this grant application will discover how specific immune cells are able to take up residence in skin early in life and how errors in this process can lead to skin diseases later in life. Our results may help establish new therapeutic approaches for patients with Atopic Dermatitis as well as other inflammatory skin diseases.

PI_NAMEs: ROSENBLUM, MICHAEL DAVID (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Ablation;Adult;Affect;Affinity;Allergic inflammation;Anatomy;anti-microbial peptide;antimicrobial;Applications Grants;Atopic Dermatitis;Attenuated;autoimmune inflammation;Binding;Biological Assay;CD4 Positive T Lymphocytes;Cell Compartmentation;cell motility;Cells;Cellular biology;Chronic;Coculture Techniques;commensal microbes;Cre driver;Cutaneous;cytokine;Development;Disease;disease model;dysbiosis;experimental study;Fibronectins;Functional disorder;Genes;genetic manipulation;Health;Helper-Inducer T-Lymphocyte;Homeostasis;Host Defense;Human;human disease;Immune;immune activation;Immune response;Immune Tolerance;Immunity;imprint;in vivo;in vivo evaluation;Inflammation;Inflammatory;innovation;innovative technologies;insight;Integrin alpha4;interdisciplinary approach;Interleukin 2 Receptor;Life;Ligands;Link;Lymphocyte;Lymphocyte Subset;Maintenance;Microanatomy;Microbe;microbial;Molecular;mouse model;Mus;Neonatal;neonatal mice;novel;novel therapeutic intervention;Organ;organ repair;pathogen;Pathogenicity;Pathway interactions;Patients;pediatric patients;Peripheral;Phenotype;Play;Population;postnatal development;Predisposition;prevent;Process;Proteins;receptor;Regulatory T-Lymphocyte;residence;response;restoration;Role;selective expression;single-cell RNA sequencing;Skin;skin disorder;skin organogenesis;Staphylococcus aureus;Stromal Cells;T cell response;T-Lymphocyte;Testing;Th2 Cells;Therapeutic;Time;tissue repair;Tissues;tool;Translating;tumor;tumorigenesis

PROJECT_TITLE: Elucidating the Role of Regulatory T cells in Establishing and Maintaining a Th2 Niche in Skin


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Biomedical Imaging;Clinical Research;Emerging Infectious Diseases;Health Services;Infectious Diseases;Pain Research;Wound Healing and Care

ORG_CITY: SEATTLE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Relevance to public health: The development of a focused ultrasound treatment for Skin and soft tissue abscesses will improve patients’ lives because it is minimally or noninvasive, has less procedural pain, can be performed in an out-patient setting, and is fast and convenient. Physicians benefit because it reduces risk associated with the current standard of care, incision and drainage (I&D) and there is minimal additional training to use the device.

PI_NAMEs: MATULA, THOMAS  (contact)

PROJECT_TERMS: Abscess;Accident and Emergency department;Accidents;Aftercare;Animal Model;Animals;Antibiotics;Antimicrobial Resistance;Area;aspirate;Bacteria;Bacteroides fragilis;Biological Markers;Blood;Breast;C-reactive protein;Cellulitis;Chronic;Cicatrix;clinically relevant;Communities;Complete Blood Count;Complex;cost;Data;Development;Devices;Drainage procedure;drug resistance development;Drug usage;Economic Burden;effective therapy;Effectiveness;effectiveness evaluation;Emergency department visit;Escherichia coli;Etiology;Evolution;Expenditure;Family suidae;Fine needle aspiration biopsy;first-in-human;Focused Ultrasound;Focused Ultrasound Therapy;Gram-Negative Bacteria;Gram-Positive Bacteria;Health Care Costs;healthcare burden;Histology;Homelessness;hospital readmission;Hospitalization;Human;image guided;imaging biomarker;improved;In Vitro;Incision and drainage;Infection;Infectious Skin Diseases;Injections;Injury;Inpatients;Intramuscular;intraperitoneal;Length of Stay;Maintenance;Measures;Mechanics;methicillin resistant Staphylococcus aureus;Methods;Modeling;Monitor;Morbidity - disease rate;Neck;Needles;Outpatients;Pain;pathogen;Pathogen detection;patient population;Patients;Persons;Physicians;Physiologic pulse;Population;porcine model;Predisposition;procedural pain;Procedures;programs;psychosocial;Public Health;Pus;Radiation exposure;Rectum;Reporting;Resistance;Resolution;Risk Factors;Risk Reduction;secondary infection;Secondary to;Site;Skin Tissue;soft tissue;Soft Tissue Infections;standard of care;Staphylococcus aureus;Streptococcus;Structure;subcutaneous;success;Technology;Time;Tissues;Training;treatment effect;Treatment Failure;Treatment Protocols;Ultrasonography;ultrasound;Viscosity;wound care;wound healing;wound treatment

PROJECT_TITLE: Focused Ultrasound Treatment of Skin and Soft Tissue Abscesses


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: ANN ARBOR

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE A critical step towards a broader use of mesenchymal stem cells in therapeutic tissue regeneration is to optimize approaches to maintain stem cell pools that enable healing and replacement of dead terminally differentiated cells in these new tissues or organs. This project is centered on the study of mechanisms regulating the generation and maintenance of neurovascular stem cell niches when dental pulp stem cells are used for tissue regeneration. Optimized approaches that support the function of these specialized stem cell niches will contribute to improving the long-term outcomes of stem cell-based therapies for tissue regeneration.

PI_NAMEs: NOR, JACQUES EDUARDO (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: Anastomosis - action;autocrine;Biology;Blood;Blood Vessels;Brain Stem;Brain-Derived Neurotrophic Factor;cadherin 5;Cell Differentiation process;Cell secretion;Cells;Central Nervous System;Data;Dental Pulp;Embryo;Embryonic Development;Endothelial Cells;Equilibrium;Event;Exhibits;experience;Experimental Designs;Funding;Generations;Goals;healing;Heterogeneity;HIF1A gene;Hippocampus;Human;Hypoxia;improved;In Vitro;in vivo;Investments;Maintenance;Mediating;Mesenchymal Stem Cells;Modeling;Mus;N-Cadherin;Natural regeneration;nerve stem cell;Neural Crest;Neurons;neurovascular;novel;novel strategies;Odontoblasts;Organ;Outcome;Pathway interactions;Patients;Peripheral Nervous System;Process;prototype;regenerative therapy;Regulation;Research;Research Design;response;Role;scaffold;self-renewal;Series;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Slice;Source;stem cell biology;stem cell differentiation;stem cell fate;stem cell function;stem cell niche;stem cell population;stem cell self renewal;stem cell therapy;stem cells;stemness;Testing;Therapeutic;Time;tissue regeneration;Tissues;Tooth structure;Transplantation;Undifferentiated;Vascular Endothelial Cell;Vascular Endothelial Growth Factors;Vascularization;vasculogenesis;Vasculogenic;Work

PROJECT_TITLE: Regulation of dental pulp stem cell fate

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Acute kidney injury is one of the most common kidney pathologies and a common cause of chronic kidney disease leading to dramatically reduced life expectancy. To date there are no clinically proven therapies for treating acute kidney injury. This application identifies dicarboxylic medium chain fatty acids that protects the kidney against acute kidney injury and has significant therapeutic potential to treat the ever-growing number of acute kidney injury patients.

PI_NAMEs: GOETZMAN, ERIC S;SIMS-LUCAS, SUNDER  (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Acceleration;Acetates;Acetyl Coenzyme A;Acids;Acute;Acute Renal Failure with Renal Papillary Necrosis;acyl-CoA oxidase;Anti-diabetic Drugs;ATP Synthesis Pathway;Biogenesis;Biological Assay;Bypass;Carbon;Cells;Cessation of life;Chronic Kidney Failure;Cisplatin;Citric Acid Cycle;Clinical;clinical translation;Coenzyme A;Consumption;Creatinine;Critical Illness;Data;Development;Dicarboxylic Acids;Diet;Dietary Supplementation;Dose;druggable target;Early Diagnosis;Early Intervention;effective therapy;efficacy evaluation;Electron Microscopy;End stage renal failure;energy efficiency;Energy Metabolism;enzyme activity;Enzyme Stability;Enzymes;Epithelial Cells;Etiology;fatty acid oxidation;Fatty Acids;feeding;functional improvement;Genetic;high risk;Hospital Costs;Hospitals;Human;improved;In Vitro;in vitro Model;in vivo;Injury;Injury to Kidney;Inpatients;Intervention;Ischemia;Kidney;Kinetics;Knock-out;LCN2 gene;Life Expectancy;Literature;LoxP-flanked allele;Lysine;Measures;Mediating;Medium chain fatty acid;Metabolic;metabolic abnormality assessment;metabolome;metabolomics;Mitochondria;Modeling;Morbidity - disease rate;Morphology;mortality;mouse model;Mus;nephrotoxicity;nonhuman primate;Oxidative Stress;Pathology;Patients;peroxisome;pharmacologic;pi bond;Post-Translational Protein Processing;Preclinical Testing;Prevention;Prevention therapy;Production;progression risk;protective effect;Proteins;Proteome;Proximal Kidney Tubules;Reactive Oxygen Species;Recovery;Reperfusion Injury;Resolution;Respiratory Chain;respiratory complex II;Rodent;Rodent Model;Role;Serum;Severities;Signal Transduction;Spirometry;Succinates;succinyl-coenzyme A;Testing;Therapeutic;Therapeutic Effect;tissue injury;Tissues;Western Blotting

PROJECT_TITLE: Dicarboxylic acid therapy for prevention of kidney injury

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Lung;Rare Diseases

ORG_CITY: MONROE

ORG_NAME: UNIVERSITY OF LOUISIANA AT MONROE

ORG_STATE: LA

PHR: The current grant application suggests to investigate the hypothesis that synthetic somatostatin analogs approved by FDA can counteract endothelial barrier dysfunction, in vivo and in vitro. Our studies will contribute in our better understanding towards the pathophysiology of illness related to barrier dysfunction (e.g. acute respiratory distress syndrome). 1

PI_NAMEs: BARABUTIS, NEKTARIOS  (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Acromegaly;Acute Lung Injury;Acute Respiratory Distress Syndrome;Affect;antagonist;Applications Grants;ATF6 gene;Blood;Blood Vessels;Cattle;cell injury;Cessation of life;Clinic;Cytoskeleton;Data;design;Development;Disease;Electrolytes;Endoplasmic Reticulum;endoplasmic reticulum stress;Endothelial Cells;Endothelium;Enzymes;Epithelium;Experimental Models;Exposure to;FDA approved;fluorescein isothiocyanate dextran;Functional disorder;Guanosine Triphosphate Phosphohydrolases;Human;In Vitro;in vivo;Inflammation;Inflammatory;inflammatory lung disease;inhibitor;Injury;Inositol;Intensive Care Units;Interferon Type II;Intramuscular;Investigation;kifunensine;Knowledge;Left;Liquid substance;lung injury;lung microvascular endothelial cells;medical countermeasure;Medicine;mouse model;Mus;Neuroendocrine Tumors;novel;novel therapeutics;Octreotide;Oral;Outcome;Permeability;pharmacologic;Phosphoric Monoester Hydrolases;Phosphotransferases;protective effect;protein folding;Protein Kinase;Proteins;Publications;Publishing;pulmonary artery endothelial cell;Regulation;repaired;response;response biomarker;RNA;Role;sensor;sepsis induced ARDS;Signal Transduction;Small Interfering RNA;somatostatin analog;Somatotropin;Somatotropin-Releasing Hormone;Stimulus;subcutaneous;Techniques;Testing;Tissues;Widespread Disease

PROJECT_TITLE: Synthetic Somatostatin Analogs Protect Against Endothelial Barrier Dysfunction

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CLEVELAND

ORG_DEPT: GENETICS

ORG_NAME: CLEVELAND STATE UNIVERSITY

PHR: Project Narrative: Dysfunctional inflammatory response to modified lipids and bacterial metabolites leads to unresolved and chronic inflammation. This project aims to identify novel pathways and mechanisms involved in promoting the inflammation-induced progression of atherosclerosis and progressive familial intrahepatic cholestasis with the goal of therapeutic interventions for treating these debilitating diseases.

PI_NAMEs: GULSHAN, KAILASH  (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Alcoholism;Area;Arterial Fatty Streak;Atherosclerosis;ATP binding cassette transporter 1;ATP phosphohydrolase;ATP8B1 gene;Autophagocytosis;Baculoviruses;Binding;Biology;Bone Marrow;Bone Marrow Transplantation;Cardiovascular Diseases;Cell membrane;Cell Physiology;Cells;Cessation of life;Chemicals;Cholesterol;Cholesterol Homeostasis;Chronic;chronic inflammatory disease;Codon Nucleotides;Data;design;Detergents;Disease;Disulfiram;efflux pump;Extrahepatic;FDA approved;feeding;Functional disorder;Genetic Diseases;Goals;Hepatic;Hepatocyte;Human;human induced pluripotent stem cells;IL18 gene;Immune response;In Vitro;in vitro activity;in vitro testing;in vivo;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Injections;Insecta;insight;Interleukin-1 beta;Investigation;Knockout Mice;Lesion;Link;Lipids;Liposomes;liver inflammation;liver injury;Macrophage;Mediating;member;Membrane;Metabolic Diseases;Metabolism;Methods;Minor;Modeling;monocyte;mortality;mouse model;Mus;mutant;Mutation;Myeloid Cells;N-terminal;novel;Pancreatitis;Pathway interactions;Patients;Pharmaceutical Preparations;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylinositols;Physiological;pre-clinical;Progressive intrahepatic cholestasis;Protein Isoforms;protein reconstitution;Proteomics;Reagent;Recombinants;Regulation;Reporter;Resistance;Role;Signal Transduction;stem cell model;Stimulus;System;Therapeutic;Therapeutic Intervention;Tissues;trafficking;Treatment Efficacy;VDAC1 gene

PROJECT_TITLE: Phosphatidylinositol Metabolism and Trafficking in Atherosclerosis and Inflammation

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: NEUROSURGERY

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE We explore the world around us through 3D body movement, but most neuroscience research focuses on more restrained movement. In this planning project, we will integrate 3D behavioral tracking and wireless neurotechnology with our experimental and theoretical expertise in animal behavior. We will study how different areas of the brain work together to encode movement, and enable a future project to understand the fundamental question of how the brain coordinates movement of the entire body in 3D.

PI_NAMEs: RODGERS, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: 3-Dimensional;Anatomy;Animal Behavior;Animal Structures;Animals;Area;arm;Auditory area;Behavior;Behavioral;Behavioral Paradigm;Body part;Brain;brain control;BRAIN initiative;Brain region;causal model;cell type;Collaborations;Complex;Computer Analysis;Computer Models;computer studies;Cortical Column;Coupling;data modeling;density;Devices;Ear;Electrophysiology (science);Environment;Equilibrium;experience;Fiber;Fingers;Forelimb;free behavior;Future;genetic manipulation;Goals;Grooming;Head;Implant;Individual;innovation;Learning;Left;Leg;Letters;Light;light weight;Link;Machine Learning;Measurement;Measures;millisecond;Mission;Monitor;Motion;Motor;Motor Cortex;Movement;Mus;Nature;neural;neural circuit;Neurons;Neurosciences;Neurosciences Research;neurotechnology;neurotransmission;new technology;optical fiber;Optics;optogenetics;Output;Pattern;Penetration;Population;Population Dynamics;Positioning Attribute;Posture;Primates;Qualifying;Research;Resolution;response;restraint;Rodent;Route;sample fixation;Sampling;Sensory;sensory input;sensory integration;Side;Signal Transduction;Silicon;sound;Source;spatiotemporal;Stimulus;Structure;System;Techniques;Technology;Testing;Theoretical model;Time;tool;Touch sensation;Training;Weight;wireless;Work

PROJECT_TITLE: Wirelessly recording and manipulating neural activity to study the sensorimotor dynamics of free behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-W (55)]