ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Glaucoma is a progressive, blinding disease for which intraocular pressure is the most significant risk factor, and yet, the mechanisms of how the eye senses pressure remain largely unknown. This project will investigate the role of mechanosensitive ion channels in glaucoma, and how human variants in mechanosensitive ion channel genes may be associated with glaucoma risk. These studies will provide fundamental insights into the mechanosensitive responses of retinal cells at the molecular and physiological level and will lay the foundation for the development of new neuroprotective therapies for glaucoma.

PI_NAMEs: LIU, WENDY W. (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Address;Affect;Astrocytes;Axon;axonal degeneration;Axonal Transport;career;career development;Cell Death;Cell Line;Cell Survival;cell type;Cells;common treatment;Communities;conditional knockout;Data;Dedications;Development;Development Plans;Disease;Disease Progression;Electrophysiology (science);Exhibits;experience;experimental study;Eye;Foundations;Funding;Genes;Genetic;genetic analysis;Glaucoma;Goals;Human;human data;Human Genetics;Immunohistochemistry;In Situ Hybridization;In Vitro;in vivo;insight;Ion Channel;Knock-out;Knowledge;Lead;Leadership;Learning;Mammals;Mechanical Stimulation;Mechanical Stress;Mechanics;Mediating;Mentors;Mentorship;Modeling;modifiable risk;Molecular;mouse model;Mus;neuroprotection;Neurosciences;new therapeutic target;Optic Disk;patch clamp;Pharmacology;Physiologic Intraocular Pressure;Physiological;Physiological Processes;Physiology;Piezo 1 ion channel;Piezo 2 ion channel;Piezo ion channels;Play;pressure;Property;Proteins;Research;research and development;Research Personnel;Resources;response;Retina;Retinal Ganglion Cells;Risk;Risk Factors;RNA;Role;Scientist;sensory neuroscience;Silicone Oils;skills;Stimulus;Stress;System;Technical Expertise;Testing;Tissues;Training;Training Programs;United States National Institutes of Health;Variant;Vision;visual neuroscience;Work

PROJECT_TITLE: The Role of Mechanosensitive Ion Channels in Glaucoma


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Clinical Research;Genetics;Immunotherapy;Prevention;Women's Health Research

ORG_CITY: DALLAS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative I discovered that invasive breast cancer cells can reprogram natural killer (NK) cells into being metastasis- promoters. I propose to determine the mechanisms driving metastases-reprogrammed NK cells and to determine its significance in human breast cancer. NK cell directed therapies could provide alternative immunotherapies for metastatic breast cancer patients and I will complete key preclinical experiments needed to translate these insights to patient benefit.

PI_NAMEs: CHAN, ISAAC  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: 3-Dimensional;Address;Advisory Committees;Antibodies;Automobile Driving;Behavior;Bioinformatics;Biological Assay;biomarker identification;Biometry;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Patient;Breast Cancer Prevention;Breast Cancer therapy;cancer cell;Cell Communication;Cell Reprogramming;Cell Surface Receptors;Cells;Cellular biology;Coculture Techniques;Combined Modality Therapy;CRISPR/Cas technology;cytotoxic;cytotoxicity;Data;differential expression;Disease;Disseminated Malignant Neoplasm;DNA methyltransferase inhibition;DNA Modification Methylases;effective therapy;Environment;Event;experimental study;Extracellular Matrix;FOSL1 gene;Frequencies;Funding;Genes;Genetic Transcription;Human;Immune;Immunologic Surveillance;Immunotherapy;improved;In Situ;in vivo;in vivo Model;Individual;Induction of Apoptosis;inhibitor;insight;Killer Cells;killer factor;Knowledge;Lectin;Ligands;Link;live cell imaging;Malignant Breast Neoplasm;Mentors;Metastatic breast cancer;Modeling;Molecular;Molecular Profiling;mortality;mouse model;Natural Killer Cells;Neoplasm Metastasis;neoplastic cell;novel;Organ;Organoids;Patients;pharmacologic;Phenotype;Physicians;Play;Postdoctoral Fellow;pre-clinical;programs;promoter;receptor;restraint;Role;Sampling;Scientist;Signal Transduction;single-cell RNA sequencing;Site;success;Techniques;Testing;Therapeutic;therapeutic target;Time;Tissues;tool;transcription factor;transcriptome sequencing;transcriptomics;Translating;tumor;tumor growth;tumor microenvironment

PROJECT_TITLE: Using natural killer cells to prevent breast cancer metastases

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: SALT LAKE CITY

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE The Engineering Solutions for Better Health project will educate secondary students and teachers about new and emerging technologies that are being used to diagnose and treat health conditions. The overarching goal is to spark students’ interest in careers related to biomedical science.

PI_NAMEs: STARK, LOUISA A (contact)

PROGRAM_OFFICER_NAME: BECK, LAWRENCE A

PROJECT_TERMS: Address;animation;Award;Biological Sciences;Biology;Biomedical Engineering;Biomedical Research;Biotechnology;Body System;career;Career Choice;Collaborations;Complex;computational reasoning;course development;curriculum development;design;Development;Diagnosis;digital media;E-learning;education resources;Educational Curriculum;Educational process of instructing;Educational workshop;efficacy evaluation;Emerging Technologies;Engineering;engineering design;Evaluation;experience;Friends;Genetic;genetic technology;Goals;Health;Healthcare;high school;High School Faculty;High School Student;Human;Individual;innovation;Instruction;interest;Internet;junior high school;K-12 science education;Learning;Life;Medicine;Methods;Multimedia;new technology;Next Generation Science Standards;Occupations;online course;Online Systems;Printing;Program Development;Publishing;Randomized, Controlled Trials;recruit;Research;Schools;Science;science education;Science of genetics;science teacher;sensory system;Students;symposium;teacher;Teacher Professional Development;Techniques;Technology;Testing;Textbooks;Underrepresented Populations;Universities;Utah;Visit;web site;Work;Workforce Development;Workplace;Writing

PROJECT_TITLE: Engineering Solutions for Better Health: Genetic Technology and Biomedical Engineering for Secondary Classrooms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Breast Cancer;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Neurosciences;Pain Research;Rehabilitation;Women's Health Research

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Many women have persistent pain and mobility limitations following breast cancer surgery. The goal of this project is to determine if deep tissue massage will reduce pain, improve mobility, and enhance quality of life.

PI_NAMEs: SEHGAL, ASHWINI  (contact)

PROGRAM_OFFICER_NAME: SAMIMI, GOLI

PROJECT_TERMS: active control group;Address;Affect;American;Appearance;Articular Range of Motion;Attention;Body Image;bone;Breast;cancer surgery;Chest;Chest wall structure;Chronic;Cicatrix;Clinical Trials;Communities;Connective Tissue;Control Groups;Development;Fatigue;flexibility;Future;Goals;grasp;Hand;Immobilization;improved;improved mobility;Individual;innovation;Intervention;intervention participants;Ligaments;Light;Malignant Breast Neoplasm;Manipulative Therapies;Massage;Medical;Mobility decline;Modeling;Moods;Muscle;Ohio;Operative Surgical Procedures;Outcome;Pain;Pain management;pain reduction;pain sensitivity;Participant;Patient-Focused Outcomes;Persistent pain;Pharmaceutical Preparations;Physical therapy;Postoperative Period;practice-based research network;Provider;psychological distress;Quality of life;Randomized, Controlled Trials;Recurrent pain;Relaxation;secondary analysis;secondary outcome;Shoulder;Sleep;Sleep disturbances;soft tissue;Source;Tissues;Touch sensation;trial design;Woman;women's morbidity;Work

PROJECT_TITLE: Pain and Immobility After Breast Cancer Surgery: A Community-Based Randomized Controlled Trial of Myofascial Massage Treatment

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ED_INST_TYPE: SCHOOLS OF LAW OR CRIMINOLOGY

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer

ORG_CITY: NEW YORK

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: JOHN JAY COLLEGE OF CRIMINAL JUSTICE

ORG_STATE: NY

PHR: A lot of chemotherapeutic agents function through the activation of p53 and other apoptotic pathways, however at least 50 percent of all cancers do not have a functional p53-pathway. The proposed research will reveal molecular and cellular networks up or down regulated in the p53-independent mode of cell death triggered by mitomycins ICLs in correlation with the ICLs structural features. Results may be used for personalized treatment consideration based on the genetic makeup of tumors, particularly tumors lacking the p53 transcriptional factor.

PI_NAMEs: CHAMPEIL, ELISE  (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: adduct;analog;Antineoplastic Agents;Apoptotic;Attention;Biochemical;Bioinformatics;Biological;Biological Assay;Biomimetics;C10;cancer cell;cancer therapy;Cell Cycle;Cell Cycle Arrest;Cell Death;Cell Death Induction;Cell Line;Cells;CHEK1 gene;chemotherapeutic agent;Clinic;Clinical;Complex;crosslink;cytotoxic;cytotoxicity;Development;DNA;DNA Adducts;DNA Interstrand Crosslinking;DNA Structure;Drug usage;experimental study;G1 Phase;genetic makeup;Goals;Human;individualized medicine;interest;K-562;Knowledge;Label;Laboratories;Malignant Neoplasms;Mammalian Cell;MCF7 cell;Mediating;Methods;Minor Groove;Mitomycin C;Mitomycins;Modeling;Modernization;Modification;Molecular;Molecular Conformation;mutant;Mutate;Mutation;novel;Outcome;Pathway interactions;personalized medicine;Pharmaceutical Preparations;Pharmacotherapy;Phosphorylation;Positioning Attribute;Post-Translational Protein Processing;Primary Lesion;Process;protein expression;Proteins;Proteomics;Research;response;Route;Signal Transduction;Stereoisomer;Structure;TP53 gene;transcription factor;Transfection;tumor

PROJECT_TITLE: Identification of critical cellular pathways triggered by mitomycins interstrand crosslinks


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Childhood Obesity;Crohn's Disease;Digestive Diseases;Infectious Diseases;Inflammatory Bowel Disease;Microbiome;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: PROJECT NARRATIVE Obesity is an insidious epidemic with few signs of abating. Over 70% of the adult U.S. population is overweight or obese, as is nearly 20% of children under the age of 19. Despite knowing that diet and exercise can prevent weight gain and promote weight loss, obesity and its associated health risks continue to rise. Is it all simply due to human behavior, or are there other factors at play? This study aims to answer whether certain bacteria in the gut can migrate out of the gut and into surrounding fat tissue where they do not typically belong. When this occurs in other parts of the body, an immune response is mounted that can lead to chronic inflammation. This may occur locally in fat tissue as well, leading to metabolic dysfunction. Therefore, findings from this study may offer a new approach to preventing accumulation of high-risk abdominal fat by eliminating the causative microbes before they leave the gut.

PI_NAMEs: DEVKOTA, SUZANNE  (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Abate;abdominal fat;Adipose tissue;Adult;Age;Antibiotics;Bacteria;Bacteriophages;bariatric surgery;Behavior;Body part;Body Weight decreased;catalyst;Cell Communication;Cells;Central obesity;Child;Childhood;Chronic;Communicable Diseases;comorbidity;Crohn's disease;diet and exercise;driving behavior;Epidemic;Fatty acid glycerol esters;fungus;Gastric Bypass;Gnotobiotic;Goals;gut bacteria;gut microbiome;Health;high risk;Human;Immune response;induced pluripotent stem cell;Inflammation;innovation;Life Style;Life Style Modification;Lipids;Literature;Love;Mediating;Mesentery;Metabolic;Metabolic dysfunction;Microbe;microbial;microorganism interaction;migration;Mus;novel strategies;obese patients;Obesity;Organism;Organoids;Overweight;Patients;Play;Population;prevent;prospective;Reporting;Risk;Testing;Tissue Expansion;Tissues;Visceral;Weight Gain

PROJECT_TITLE: Is Obesity an Infectious Disease?: Gut bacterial and fungal translocation as an underappreciated driver of visceral adipose expansion.


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Infectious Diseases;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAINT LOUIS

ORG_DEPT: PEDIATRICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Astroviruses are emerging causes of central nervous system disease in humans with a mortality rate over 50%, however, the models to study how these viruses cause human disease are limited. We have developed a human cerebral organoid (“mini brains”) model that supports replication of astrovirus VA1, enabling deeper insights into the mechanisms of astrovirus neuropathogenicity. By understanding how these viruses cause central nervous system diseases, we can develop better interventions and therapeutics to prevent and treat human infections caused by astroviruses.

PI_NAMEs: JANOWSKI, ANDREW BOK SENG (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Address;Affect;Apoptosis;astrocyte progenitor;Astrocytes;Astrovirus;Award;Biological Assay;Biological Models;Brain;brain tissue;burden of illness;CASP3 gene;Cattle;Cell Communication;Cell Culture System;Cell Culture Techniques;Cell Death;Cell Lineage;cell type;Cells;Cellular Tropism;Central Nervous System;Central Nervous System Diseases;Central Nervous System Infections;central nervous system injury;Cerebrum;chemokine;Clinical;CXCL10 gene;cytokine;Data;Death Rate;Detection;Disease;Dissection;emerging pathogen;Encephalitis;Etiology;Exposure to;Fluorescent in Situ Hybridization;Funding;Future;Genotype;Glial Fibrillary Acidic Protein;Goals;Histology;Hour;Human;human disease;Immunocompromised Host;Immunohistochemistry;Immunosuppression;In Situ Hybridization;In Situ Nick-End Labeling;in vivo;Individual;Induced Neurons;Induction of Apoptosis;Infection;Inflammatory;insight;Intervention;Leukocytes;Life Cycle Stages;Lymphopenia;Mediating;Modeling;Morphology;Mus;nerve stem cell;Neurologic;neuron apoptosis;Neuronal Injury;Neurons;neuropathology;novel;Organoids;Pathogenesis;Pathology;Pathway interactions;Population;Prevalence;prevent;Protocols documentation;Publishing;receptor;Research;Research Personnel;response;RNA;Seroprevalences;Signal Pathway;single-cell RNA sequencing;Stains;Structure;Study models;Supporting Cell;Survivors;System;Testing;Therapeutic;therapeutic development;TNF gene;tool;transcriptome;transcriptome sequencing;Tropism;Viral;viral RNA;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Characterization of a cerebral organoid model of astrovirus VA1 infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-S(02)]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Mental Health;Neurosciences

ORG_CITY: BOSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: There is a need to link brain activity to human movement, perception and cognition, and social communication in real time, and in the Everyday World. This project aims to develop a multi- modal wearable functional neuroimaging device to study brain function in freely behaving healthy subjects and to track the breakdown of normal brain function potentially revealing brain patterns that are signatures of these conditions.

PI_NAMEs: BOAS, DAVID A (contact);KIRAN, SWATHI

PROGRAM_OFFICER_NAME: WANG, SHUMIN

PROJECT_TERMS: Acceleration;Adult;Algorithms;Area;Behavior;Behavioral;Blood Vessels;Brain;Brain imaging;Clinical;Cognition;Communication;Complement;Complex;Computer Vision Systems;Data;density;design;Development;Devices;Disease;Electrodes;Engineering;Environment;experimental study;Failure;Foundations;frontier;Functional Magnetic Resonance Imaging;functional near infrared spectroscopy;Future;Glass;Goals;hemodynamics;Hour;Human;Hybrids;Imaging Device;Individual;innovation;insight;instrument;Investigation;Laboratories;light weight;Link;Maps;Measurement;Measures;Methods;millisecond;miniaturize;Monitor;Morphologic artifacts;Motion;Movement;multimodality;multisensory;Nervous System Disorder;neural;neurofeedback;neuroimaging;Neurologic;Neurons;Neurosciences;new technology;next generation;Noise;novel;novel strategies;Parkinson Disease;Pattern;Perception;Phase;Physiological;Population;portability;Positioning Attribute;Predisposition;Rehabilitation therapy;Research;Research Personnel;response;Sampling;Scientist;sensory stimulus;signal processing;Signal Transduction;social communication;Social Interaction;Speech;Stroke;Support System;System;Techniques;Technology;Text;Time;tool;Translations;visual tracking;Walking;wearable device;Work

PROJECT_TITLE: The Neuroscience of Everyday World- A novel wearable system for continuous measurement of brain function


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: IOWA CITY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE The United States faces a crisis due to the high prevalence of chronic pain and associated opioid use disorder and overdose deaths. New non-addictive pain treatments using both pharmacological and non-pharmacological approaches including physical therapy and psychotherapy, are urgently needed. This multidisciplinary training program is designed to prepare new investigators in the field of pain to become independent researchers that can address the chronic pain problem from a multidisciplinary approach that includes discovery of new mechanisms and treatment, and translation of these to clinical pain populations.

PI_NAMEs: SLUKA, KATHLEEN A;USACHEV, YURIY M (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Pain Research;Training Programs

PROJECT_TITLE: Interdisciplinary Training Program in Pain Research


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Hematology;Pediatric;Prevention;Rare Diseases;Sickle Cell Disease

ORG_CITY: KAMPALA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES

PHR: Project Narrative: The mortality and morbidity due Sickle Cell Disease, a genetic blood disorder predominantly found in sub- Saharan Africa, has been reduced in high income countries using evidence-based interventions. This project aims to implement innovations including electronic registry, standards of care, as well as cohort and implementation science research to transform SCD outcomes in this setting. The anticipated findings of the project will inform policy formulation and sustainable roll out of evidence-based interventions in Uganda and the rest of sub-Saharan Africa.

PI_NAMEs: KIGULI, SARAH  (contact)

PROGRAM_OFFICER_NAME: LOUDEN, ANDREW

PROJECT_TERMS: Acute;acute chest syndrome;Address;Adolescent;Adopted;Adoption;Adult;Affect;Africa South of the Sahara;African;Age;Anemia;Area;biobank;burden of illness;Caring;Cessation of life;Characteristics;chemotherapy;Child;Child Health;Child Mortality;Childhood;Clinic;clinical care;clinical phenotype;cohort;Cohort Studies;college;Comprehensive Health Care;Consent;Country;Data;data management;Databases;Detection;Diagnosis;Disease;Disease Management;Disease Outcome;disease registry;electronic registry;Electronics;Erythrocytes;Ethical Issues;Ethics;evidence base;Evidence based intervention;fighting;Formulation;Funding;Genes;Genetic;Genetic Counseling;Goals;graduate student;Grant;Guidelines;Health;Health Sciences;Hematological Disease;Hematology;Hemoglobin;Hereditary Disease;High Prevalence;hydroxyurea;implementation research;implementation science;improved;Income;Individual;Infection;innovation;Intervention;Investments;Legal;Life;Maintenance;Medical;Microalbuminuria;Morbidity - disease rate;mortality;Natural History;Neonatal Screening;Neurocognitive Deficit;Oncology;Outcome;Pain;Participant;participant enrollment;Patient-Focused Outcomes;Patients;pediatric department;Penicillins;Phenotype;Policies;Prevalence;Prevention;Preventive;programs;Prophylactic treatment;Recording of previous events;Records;recruit;Recurrence;Registries;Research;Research Project Grants;research study;Resources;Rest;screening;screening program;SERPINI2 gene;Sickle Cell;Sickle Cell Anemia;sickling;Site;Stroke;student training;success;System;Time;Training;trait;Uganda;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Sickle Pan-African Research Consortium (SPARCO) Uganda: Strengthening Capacity for Clinical Care, Research and Training in Sickle Cell Disease - SCRT Project.


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE Family-based treatment (FBT), the current gold standard for program for child weight management, is not effective for children who are high on food cue responsiveness, a risk factor for weight regain. This application tests a novel model that targets appetitive traits, called Regulation of Cues (ROC), and compares ROC to FBT, ROC + nutrition education and caloric restriction, and a health education comparator. Results of this study could provide a more potent and durable model for the treatment of children with overweight or obesity who are high in food cue responsiveness and can inform clinical decision making.

PI_NAMEs: BOUTELLE, KERRI N (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Address;Adult;Aftercare;arm;Behavior;Behavior Therapy;Behavioral;Behavioral Mechanisms;Behavioral Paradigm;Body mass index;Body Weight Changes;Body Weight decreased;Caloric Restriction;Child;Child Rearing;clinical decision-making;comorbidity;craving;Cues;Data;demographics;Desire for food;Eating;Educational Activities;effective therapy;efficacy evaluation;Energy Intake;Enrollment;Family;follow-up;Food;Goals;Health education;Hunger;Hyperphagia;improved;Laboratories;Learning;Maintenance;Mediator;Medical;Minnesota;Modeling;novel;nutrition;nutrition education;Obesity;Outcome;Overweight;Parents;Patient Self-Report;Phenotype;Physical activity;pilot test;Predisposition;programs;Protocols documentation;Psychophysiology;Randomized;Randomized, Controlled Trials;recruit;Regulation;Research;response;Risk Factors;Satiation;Self Management;Site;skills;success;Techniques;Testing;theories;Time;trait;treatment effect;Treatment outcome;treatment program;treatment response;Universities;Weight;weight loss intervention;weight loss program;Weight maintenance regimen

PROJECT_TITLE: Addressing appetitive traits to promote weight management in children who overeat

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative: The lack of knowledge surrounding the role of human pericytes in microvascular homeostasis and fibrosis have prevented us from developing appropriate therapeutic strategies that will prevent the genesis, progression and dysfunction of tissues that are affected by fibrosis. Therefore, this proposal describes the investigation of mechanisms that facilitate pericyte remodeling of the vascular wall and interstitial tissue in support of tissue health and dysregulation. This work will translate basic understanding of pericyte biology to therapeutic intervention for fibrotic disorders of pericyte abundant tissue, including the lung, skin, heart, kidney and liver.

PI_NAMEs: GONZALEZ, ANJELICA  (contact)

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: 3-Dimensional;Actins;Acute;Adopted;Adoption;Affect;Animal Model;Area;Automobile Driving;Biochemical;Biocompatible Materials;Biological Assay;Biology;Biomedical Engineering;Blood capillaries;Blood Vessels;Cell Adhesion Molecules;Cell Reprogramming;cell type;Cells;Chemicals;Chronic;Clinical;clinically relevant;Deposition;design;Development;Diagnosis;Disease;disease diagnosis;Dropout;Endothelium;Epithelial Cells;Event;experience;Exposure to;Extracellular Matrix;Extracellular Matrix Proteins;Fibrosis;Functional disorder;Growth;Growth Factor;Health;Heart;Homeostasis;Human;In Situ;in vitro Model;Individual;Inflammation;Inflammatory;Influentials;Integrins;interstitial;Interstitial Lung Diseases;Intervention;Investigation;Kidney;Knowledge;Lesion;Liver;Lung;Maintenance;MCAM gene;mechanical signal;Mechanics;Mediating;Mediator;Metabolic;Methods;Microvascular Dysfunction;Mitochondria;Molecular;Molecular Biology;Monitor;mouse model;Myofibroblast;necrotic tissue;Organ;Pathologic;Pathway interactions;Patients;Pericytes;Permeability;Phenotype;Polymers;Population;prevent;Process;Profibrotic signal;programs;protein biomarkers;Publishing;Pulmonary Fibrosis;Regulation;response;RNA marker;Role;Sampling;Severity of illness;Signal Transduction;Skin;Smooth Muscle;Source;Staging System;stem;stem cell biomarkers;stem cells;stemness;Structure;Technology;Therapeutic;Therapeutic Intervention;therapeutically effective;Time;Tissues;transcriptome sequencing;Transforming Growth Factor beta;Transforming Growth Factors;Translating;vascular contributions;vascular injury;Vascular remodeling;Work

PROJECT_TITLE: Pericyte reprogramming in fibrosis


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Infectious Diseases;Neurodegenerative;Neurosciences;Prevention;Sexually Transmitted Infections

ORG_CITY: CHARLESTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE: RELEVANCE About half the people aged 85 or over suffer from Alzheimer disease. Increasing evidence implicates herpes simplex virus type 1, a common herpesvirus, in this disease, and this project aims to investigate how certain genes influence immunity to this virus in patients with Alzheimer’s disease. Results of this investigation may help identify novel targets of immunotherapy against this disorder.

PI_NAMEs: PANDEY, JANARDAN P (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Address;Affinity;African American;aged;Alleles;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease risk;American;Antibodies;Antibody Response;antibody-dependent cell cytotoxicity;antibody-dependent cellular phagocytosis;Antigen-Antibody Complex;Apolipoprotein E;apolipoprotein E-4;Brain Diseases;Candidate Disease Gene;Cells;Chromosome 14;Chromosomes;cohort;Complex;Cystic Fibrosis;Dementia;Development;Disease;DNA;Environmental Risk Factor;Etiology;European;Exclusion;Fc domain;Frequencies;Gene Modified;Genes;Genetic;Genetic Variation;genome wide association study;Genotype;genotyping technology;Glycoproteins;Haplotypes;Heavy-Chain Immunoglobulins;Herpesviridae;Herpesvirus 1;Humoral Immunities;IgG1;Immune system;Immunity;Immunobiology;Immunoglobulin G;Immunoglobulin Genes;Immunoglobulins;Immunologic Surveillance;Immunologics;Immunotherapy;Infection;interest;International;Investigation;Late Onset Alzheimer Disease;Ligation;Link;Literature;Mediating;Meta-Analysis;Neurons;novel;older adult;pathogen;Pathogenesis;Pathway interactions;Patients;Persons;Phagocytes;Population;Population Group;Prevalence;Proteins;receptor;Receptor Gene;Recurrence;Reporting;response;Risk;risk variant;Role;Simplexvirus;study population;Susceptibility Gene;Testing;vaccine candidate;Viral;virtual;Virus;Waxes

PROJECT_TITLE: Immunoglobulin Genes and Immunity to HSV1 in Alzheimer's Disease


ORG_CITY: DURHAM

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Although immunotherapy has revolutionized the management of cancer patients, most tumors remain poorly responsive to existing immunotherapies. The proposed studies will define the potential of a new CAR T cell formulation that could be implemented against multiple human malignancies. These studies will support novel clinical trials, designed to overcome the hitherto insurmountable challenge of controlling many epithelial malignancies using cellular therapies.

PI_NAMEs: CONEJO-GARCIA, JOSE R (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Ablation;Antibodies;Beds;Cancer cell line;Cancer Patient;cancer type;CAR T cell therapy;Cell surface;Cell Therapy;Cellular Stress;chimeric antigen receptor T cells;Cholangiocarcinoma;Chronic;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Conduct Clinical Trials;design;Effectiveness;effector T cell;Eligibility Determination;empowerment;endoplasmic reticulum stress;engineered T cells;Epithelium;Esophagus;experimental study;Extracellular Domain;first-in-human;Formulation;Functional disorder;Genetic Engineering;Goals;Hematologic Neoplasms;high reward;high risk;Histologic;Histology;Human;IgG1;Immunotherapy;in vivo;Infusion procedures;Intervention;Intrahepatic Cholangiocarcinoma;Kidney;Length;Life;Malignant neoplasm of prostate;Malignant Neoplasms;malignant stomach neoplasm;Mediating;Metabolic;Methods;Monoclonal Antibodies;mRNA Expression;neoplastic cell;Non-Small-Cell Lung Carcinoma;Normal tissue morphology;novel;olfactory receptor;Organ;Paralysed;Pathway interactions;patient derived xenograft model;Patients;pre-clinical;prevent;prospective;Prostate;Proteins;Recombinants;Resistance;Risk;Signal Transduction;Solid;Solid Neoplasm;Specificity;Stains;success;System;T-Lymphocyte;Technology;Testis;The Cancer Genome Atlas;Therapeutic;Tissues;Toxic effect;Translating;tumor;Tumor Antigens;tumor growth;tumor heterogeneity;Work;XBP1 gene

PROJECT_TITLE: OR2H1 is an effective target for CAR T cells in human epithelial tumors


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Fexinidazole is the promising first oral monotherapy against Human African Trypanosomiasis and is being explored for the treatment of other trypanosomatid infections, yet its mechanism of action, cytotoxic effects, and potential for drug resistance have not been thoroughly investigated. Here, a state-of-the art forward genetic screen has identified proteins with functions in redox and ROS metabolism in a putative fexinidazole resistance pathway, the specificity of which will be evaluated in this proposal through additional targeted genetic screens. Proteins promoting fexinidazole resistance will be analyzed using an unbiased phenotyping pipeline that will provide functional data, determine the role of ROS and redox in drug resistance, evaluate their potential as novel drug targets, and, ultimately, be transformative in the treatment of trypanosomatid infections.

PI_NAMEs: HOVEL-MINER, GALADRIEL ASTRA (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: African;African Trypanosomiasis;American Leishmaniasis;Antiparasitic Agents;Benznidazole;Cell Cycle;Chagas Disease;Clinical;Clinical Trials;clinically significant;Combined Modality Therapy;comparative;cytotoxic;Data;dithiol;DNA;DNA biosynthesis;DNA Damage;drug development;drug mechanism;Drug Metabolic Detoxication;Drug resistance;Drug resistance pathway;Drug Targeting;Enzymes;Evaluation;Family;fexinidazole;Free Radical Formation;Future;gain of function;Genes;Genetic;Genetic Screening;Giardiasis;global health;glutaredoxin;Glutathione S Transferase A;Grant;Heterocyclic Compounds;high reward;Human;In Vitro;Infection;innovation;insight;knock-down;Knowledge;Laboratories;Leishmania;Leishmaniasis;Libraries;Lipids;Medicine;Metabolism;Metronidazole;Mitochondria;Molecular;molecular drug target;mutant;Mutation;new therapeutic target;Nifurtimox;Nitroreductases;novel;Open Reading Frames;Oral;Outcome;Oxidation-Reduction;Oxidoreductase;Pathway interactions;Peroxidases;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Prodrugs;Proteins;Publications;Reactive Oxygen Species;Recommendation;Research;Resistance;resistance gene;resistance mechanism;Risk;RNA Interference;Role;screening;Specificity;Stress;stress management;success;Sulfhydryl Compounds;System;Testing;Therapeutic;tool;Trichomonas Infections;Trypanocidal Agents;Trypanosoma;Trypanosoma brucei brucei;Trypanosoma cruzi;Work;Xenobiotics

PROJECT_TITLE: Fexinidazole survival genes implicate a novel redox-based mechanism in drug resistance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-B(83)]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Disability Research;Headaches;Migraine;Neurosciences;Pain Research

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Migraine, a chronic intermittent headache disorder, ranks in the top five causes for years lived with disability. One promising non-pharmacologic and integrative treatment for migraine may be chiropractic care due to the co-occurrence of migraine and musculoskeletal complaints. The goal of this application is to perform a pilot study of chiropractic care for episodic migraine to help inform the design of a future, full-scale pragmatic effectiveness trial.

PI_NAMEs: RIST, PAMELA M.;SICO, JASON JONATHON;WAYNE, PETER MICHAEL (contact)

PROGRAM_OFFICER_NAME: MURRAY, PETER DANIEL

PROJECT_TERMS: Academic Medical Centers;Address;Adherence;Adult women;Agreement;arm;Attention;Boston;Caring;Chiropractor;chiropracty;Chronic;chronic pain management;Clinic;Clinical;Clinical Trials;comorbidity;Complex;Data Collection;data harmonization;data management;Data Reporting;data sharing;design;Development;disability;disability burden;Education;Effectiveness;effectiveness evaluation;evidence base;Exercise;expectation;experience;follow-up;Foundations;Frequencies;Functional disorder;Future;Goals;Headache;Headache Disorders;Health education;High Prevalence;Individual;Infrastructure;Institutional Review Boards;Integrative Therapy;interest;Intervention;Jaw;joint mobilization;Knowledge;Medical;Medical center;meetings;men;Meta-Analysis;Methods;Migraine;migraine treatment;Modeling;multi-component intervention;multi-site trial;multimodality;Muscle Tension;Musculoskeletal;National Center for Complementary and Integrative Health;Neck;Neck Pain;Nonpharmacologic Therapy;Outcome;Pain;Pain intensity;Participant;Patients;Pharmaceutical Preparations;Pilot Projects;Population;Posture;pragmatic trial;Preparation;Procedures;programs;Protocols documentation;Randomized;randomized, clinical trials;recruit;Reporting;Reproducibility;Risk;Running;Severities;side effect;Site;Spinal Manipulation;Stretching;study population;Symptoms;Techniques;Testing;Training;Translational Research;treatment as usual;virtual;Visit;Woman;years lived with disability

PROJECT_TITLE: Chiropractic Care for Episodic Migraine


NIH_SPENDING_CATS: Brain Disorders;Congenital Muscular Dystrophy;Congenital Structural Anomalies;Intellectual and Developmental Disabilities (IDD);Muscular Dystrophy;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PI_NAMEs: MOHASSEL, PAYAM  (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Affinity;Alleles;Animal Model;Area;Atrophic;Attention;Bethlem Myopathy;Binding;Binding Proteins;Biological Assay;Biopsy;Blinded;career;Cells;COL6A1;COL6A2;COL6A3;Collagen Gene;Collagen Type VI;Complex;Confocal Microscopy;Data;Defect;design;disability;Disease;disease model;disease natural history;drug candidate;effectiveness testing;efficacy study;Excretory function;extracellular;Extracellular Matrix;Extracellular Matrix Proteins;Fibroblasts;Fibrosis;Fluorescence Resonance Energy Transfer;Funding;Future;gel electrophoresis;Genes;Goals;Growth Factor;Histologic;Human;Immunoprecipitation;In Vitro;inhibitor;Injury;Intervention;Investigation;Laboratories;Luciferases;Medicine;MFAP1 gene;Microscopy;Modeling;Monoclonal Antibodies;mouse model;Mus;Muscle;Muscle Proteins;muscle regeneration;Muscle Weakness;Muscular Atrophy;Muscular Dystrophies;Mutation;Myopathy;Natural regeneration;neuromuscular;novel;Outcome Measure;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;Physiological;postnatal;preclinical study;prospective;Proteins;Randomized;receptor;recruit;Regenerative pathway;Regenerative response;Regulation;Reporter;Research Project Grants;research study;Resolution;response to injury;Role;Scientist;Severity of illness;Signal Pathway;Signal Transduction;Skeletal Muscle;skills;Small Interfering RNA;Source;Standardization;Techniques;Tertiary Protein Structure;Testing;therapeutic target;Training;transcriptome;Transforming Growth Factor beta;Translational Research;Translations;Ullrich Congenital Muscular Dystrophy;United States National Institutes of Health;Up-Regulation

PROJECT_TITLE: The role of TGF beta pathway dysregulation in pathogenesis of collagen VI-related muscular dystrophy

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Heart Disease - Coronary Heart Disease;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: MADISON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: The proposed research is relevant to public health because it aims to reduce cardiac side effects for cancer patients who undergo radiation therapy. Using advanced image processing methods and a new radiation machine that uses MRI to change the radiation and track tumors during radiation delivery, precise model of sensitive heart components and determine the best way to effectively spare them from radiation. A clinical trial will be conducted to evaluate potential improvements in cardiac function, side effects, and quality of life using our innovative techniques.

PI_NAMEs: GLIDE-HURST, CARRI KAYE (contact)

PROGRAM_OFFICER_NAME: FARAHANI, KEYVAN

PROJECT_TERMS: Acute;Acute Coronary Event;Aftercare;Angiography;Atlases;Attention;automated treatment planning;Benchmarking;Biological Markers;Blood;Breast;cancer complication;Cancer Intervention;Cancer Patient;Cancer Survivor;cancer therapy;Cardiac;cardiac magnetic resonance imaging;Cardiac Volume;Cardiology;Cardiotoxicity;Chest;Clinical;clinical efficacy;clinical practice;Clinical Trials;comorbidity;Complex;computer science;cone-beam computed tomography;Congestive Heart Failure;Coronary;Coronary Arteriosclerosis;Coronary artery;Coupled;Coupling;Data;deep learning;Dose;Echocardiography;Emerging Technologies;Esophagus;Evaluation;Exhibits;experience;Future;Generations;generative adversarial network;Goals;Heart;Heart Atrium;heart function;Hour;Image;image processing;improved;improved outcome;Incidence;innovation;Life Expectancy;Linear Accelerator Radiotherapy Systems;Link;Longterm Follow-up;Lung;Lymphoma;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Childhood Neoplasm;Malignant neoplasm of esophagus;Malignant neoplasm of lung;Malignant neoplasm of thorax;Malignant Neoplasms;Manuals;Meta-Analysis;Methods;minimally invasive;Modality;Modeling;Modification;Morbidity - disease rate;Motion;multi-task learning;multidisciplinary;multimodality;new technology;Non-Small-Cell Lung Carcinoma;novel;Oncology;Organ;Outcome;Patients;Pericardial effusion;pericardial sac;prospective;Public Health;Quality of life;Radiation;radiation delivery;Radiation Dose Unit;radiation mitigation;Radiation therapy;Radiation Therapy Oncology Group;Radiation Tolerance;Radiology Specialty;randomized, clinical trials;Research;respiratory;response;Risk;Roentgen Rays;Safety;Scanning;side effect;simulation;soft tissue;standard of care;Techniques;Technology;Therapeutic;Translations;treatment planning;Treatment-Related Cancer;tumor;Uncertainty;United States National Institutes of Health;Validation;volunteer;wearable data;X-Ray Computed Tomography

PROJECT_TITLE: Reducing cardiac toxicity with deep learning and MRI-guided radiation therapy

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Diabetes;Digestive Diseases;Pediatric;Prevention;Transplantation

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Acute pancreatitis is common and increasing in both incidence and prevalence in the United States, with risk of subsequently developing exocrine insufficiency and/or diabetes approaching 30%. Hence, efforts to understand the mechanisms, risk factors, and predictors of diabetes following acute pancreatitis are of significant public health importance to facilitate the development of strategies for early detection, prevention, and effective management. Through the framework provided by the Type 1 Diabetes Acute Pancreatitis Consortium (T1DAPC), the combined University of Florida and AdventHealth team will serve as a high-volume center contributing to patient enrollment and collection of biological samples for mechanistic and clinical studies to characterize diabetes pathogenesis following acute pancreatitis, ultimately in support of future efforts to identify accurate biomarkers and more effective therapies.

PI_NAMEs: FORSMARK, CHRISTOPHER E (contact);HUGHES, STEVEN J;PRATLEY, RICHARD E

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Acute;acute pancreatitis;Address;Alpha Cell;Area;Arginine;Autoantibodies;Autoimmune;Bayesian Analysis;Beta Cell;biobank;Biological;Biological Markers;Blood;Blood specimen;Cell Physiology;Cells;Clinical;clinical center;clinical diagnosis;Clinical Research;cohort;Collection;Coupled;Custom;Data;Development;Diabetes Mellitus;diabetes mellitus therapy;diabetes pathogenesis;diabetes risk;DNA;Early Diagnosis;effective therapy;endocrine pancreas development;Endoscopic Retrograde Cholangiopancreatography;Enrollment;Etiology;experience;Fatty acid glycerol esters;Feces;Fibrosis;Florida;follow-up;Functional disorder;Future;Genetic;Genetic Risk;Genotype;Glucose tolerance test;Health;Health system;high risk;Histologic;Hospitalization;Human;human subject;Image;Immune;Immunohistochemistry;Immunologics;Incidence;indexing;Individual;Inflammatory;Infrastructure;Insulin;Insulin deficiency;Insulin Resistance;insulin secretion;Insulin-Dependent Diabetes Mellitus;insulitis;internal control;islet;islet autoimmunity;Islet Cell;Laboratories;Location;Magnetic Resonance Imaging;Measures;Metabolic;Morphology;Necrosis;novel marker;OGTT;Organ;Organ Donor;Organ Procurements;Pancreas;pancreas imaging;Pancreatic Diseases;Pancreatic duct;pancreatic juice;Pancreatic Polypeptide;Pancreatitis;participant enrollment;Pathogenesis;Patient Admission;Patients;Phenotype;Population;Prevalence;Prevention;Procedures;Process;programs;prospective;Prospective cohort;Public Health;Radioimmunoassay;Recording of previous events;recruit;regeneration potential;Relapse;Research Institute;Research Personnel;Research Support;Resources;Risk;Risk Factors;risk stratification;Saliva;saliva sample;Sampling;Staging;Statistical Data Interpretation;Structure;System;Testing;Tissue and Organ Procurement;Tissue Sample;Tissues;translational health science;Translational Research;Transplantation;United States;Universities;Urine;Visit;Work

PROJECT_TITLE: Type 1 Diabetes in Acute Pancreatitis Consortium - Clinical Centers


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative: Type 2 diabetes is a costly disease that is more prevalent in Latino families. This study will test the effects of a diabetes prevention program for Latino families who are at risk for diabetes. We will also look for ways to expand diabetes prevention programs across multiple communities through partnerships.

PI_NAMEs: SHAIBI, GABRIEL QUANTUM (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: access disparities;Address;Adolescent;Adopted;Adult;Area;Arizona;Biological;Body Composition;Child;cohesion;Collaborations;Communities;community organizations;community partners;comparison control;Complex;cost;Cost of Illness;cultural values;Data;Diabetes Mellitus;Diabetes prevention;diabetes prevention program;diabetes risk;Diffusion;Disease;Effectiveness;efficacy testing;empowerment;Evidence based intervention;experience;Exploration, Preparation, Implementation, and Sustainment;Family;Family health status;Family Process;family structure;Funding;glucose tolerance;Glycosylated hemoglobin A;Goals;Health;Health behavior;Health behavior and outcomes;health equity;Health Services Accessibility;high risk;hybrid type 1 design;improved;Individual;Intervention;Latino;Latino Population;learning community;life span;lifestyle intervention;lifetime risk;Link;low health literacy;Mediator;Methods;minority communities;Modeling;Morbidity - disease rate;National Institute of Diabetes and Digestive and Kidney Diseases;neighborhood disadvantage;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;Obesity;Outcome;outcome disparities;Parents;peer;Population;Positioning Attribute;Prediabetes syndrome;Predisposition;Premature Mortality;Prevalence;prevent;Prevention;Prevention trial;preventive intervention;psychosocial;Quality of life;Readiness;Research Personnel;resilience;Risk Factors;Series;social;social determinants;System;Testing;Time;Translating;Underserved Population;United States National Institutes of Health;vulnerable community;Vulnerable Populations;Youth

PROJECT_TITLE: Preventing Diabetes in Latino Families

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Genetics;Neurosciences

PHR: PROJECT NARRATIVE Systematic classification of molecularly defined neurons has dramatically increased in recent years, but the function of these cell types is largely unexplored due to bottlenecks in relating gene expression to neuron activity. In this proposal we will optimize for broad dissemination to the research community a pipeline of imaging, gene expression, and viral tools for highly parallelized evaluation of molecularly defined neuron activity during behavior. This approach is greatly needed to understand cell types associated with physiological and emotional functions in the healthy brain and disease states.

PI_NAMEs: CUI, MENG ;STERNSON, SCOTT M (contact)

PROGRAM_OFFICER_NAME: TALLEY, EDMUND M

PROJECT_TERMS: adaptive optics;Adoption;Animal Behavior;Anterior;Area;Axon;Back;Bar Codes;Behavior;Behavioral;Brain;BRAIN initiative;Calcium;Cell Physiology;cell type;Cells;Censuses;Characteristics;Classification;Code;Collaborations;commercialization;Communities;computerized tools;Computing Methodologies;Data;Democracy;Disease;emotional functioning;Engineering;Evaluation;ex vivo imaging;experimental study;Fluorescent in Situ Hybridization;Fright;Funding;Gene Expression;Gene Expression Profiling;Generations;Genes;Genetic Markers;Genetic Transcription;Goals;high dimensionality;hindbrain;Hunger;Hypothalamic structure;Image;image registration;improved;In Situ Hybridization;in vivo;in vivo calcium imaging;in vivo imaging;indexing;Individual;information processing;Investigation;Lateral;lens;Measurement;Methodology;Methods;Microscopy;Molecular;motivated behavior;multimodal data;Mus;Nervous System;neural patterning;neuronal circuitry;Neurons;Neurosciences;NIH Program Announcements;Noise;Obesity;parallelization;Pattern;Physiological;Procedures;Property;Pupil;Research;response;RNA;Role;Serotyping;Signal Transduction;Speed;Structure;success;System;Technology;Thick;Thirst;Tissues;tool;Transcript;transcriptomics;two-photon;Viral;Viral Vector;Work

PROJECT_TITLE: Optimization of Calcium and RNA multiplexed activity imaging for highly parallelized evaluation of cell type functions in deep-brain structures


ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

ORG_STATE: CO

PHR: The mechanism of eosinophilic asthma in non-allergic patients is poorly understood. This proposal examines the role of innate lymphoid cells and its memory for environmental factors in eosinophilic non-allergic asthma. A successful completion of this research will lead to identification of novel therapeutic targets for treatment of this form of asthma.

PI_NAMEs: ALAM, RAFEUL  (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Abbreviations;Ablation;Adoptive Transfer;Adult;Adult asthma;airway hyperresponsiveness;Allergens;Allergic;Alternaria;Antigens;Asthma;Asthma COPD Overlap Syndrome;asthma model;asthmatic patient;ATAC-seq;Atopic Dermatitis;B-Lymphocytes;BACH2 gene;Chronic;Clinical;cross reactivity;Cytokine Gene;dectin 1;derepression;disorder control;Dose;Environmental Risk Factor;Eosinophilia;eosinophilic asthma;Eosinophilic Esophagitis;eosinophilic inflammation;Epigenetic Process;experimental study;Exposure to;Extrinsic asthma;Family;Flow Cytometry;Frequencies;gene repression;Genes;Genetic;Genomic approach;Human;IL5 gene;Immune;inhibitor;innovation;Intervention;Knowledge;LIM Domain;loss of function;Lymphoid Cell;MAPK3 gene;Memory;Modeling;Molecular;mouse model;Mus;new therapeutic target;novel;Oncogenes;Osteosarcoma;pathogen;Pathogenesis;Pathway interactions;Patients;Pattern;Pattern recognition receptor;Pharmaceutical Preparations;Play;Population;prevent;Production;programs;Property;Proteinase-Activated Receptors;Rag1 Mouse;Readiness;receptor;reconstitution;Refractory;Reporting;Repression;Research;response;Role;Saline;Sampling;Signal Transduction;single-cell RNA sequencing;Source;Stains;Steroid Resistance;Steroids;Subtilisins;T-Lymphocyte;Testing;Th2 Cells;Therapeutic;therapeutic evaluation;Time;tool;Transcription Factor AP-1;transcriptome sequencing;transcriptomics;Western Blotting;Wild Type Mouse

PROJECT_TITLE: ILC2 memory in asthma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(57)S]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Mental Health;Pediatric;Social Determinants of Health;Violence Research;Youth Violence

PHR: PROJECT NARRATIVE A growing number of U.S. middle and high schools are implementing commercially available social media surveillance (SMS) of students in an effort to address youth mental health and school safety. Although SMS technology is increasingly being purchased by schools, there has been no systematic assessment of the ethical, legal, and social implications, including how it affects the students whom it purportedly aims to help. This project will document the ways in which SMS is currently being used by school administrators across the U.S., assess the perspectives of students and parents, and develop and disseminate student-centered policy recommendations.

PI_NAMEs: BLOSS, CINNAMON S (contact)

PROGRAM_OFFICER_NAME: LUSHIN, VICTOR

PROJECT_TERMS: Address;Administrator;Adverse effects;Affect;Area;behavior measurement;bullying;Catalogs;Characteristics;Computer software;Congresses;Consensus;Data;digital;Discrimination;Education;Educational workshop;Ethical Analysis;ethical, legal, and social implication;Ethicists;Evaluation;Expenditure;Focus Groups;Future;Geography;Goals;Guidelines;gun violence;Health Promotion;high school;insight;Institutional Obligations;interest;Intervention Studies;Interview;Investigation;junior high school;Legal;marginalized population;Mental Health;mental health center;Methodology;Methods;Minority Groups;minority student;Monitor;Motivation;news;Outcome;Parents;Perception;Policies;policy recommendation;Privacy;Probability;Process;Psychiatrist;psychologic;Psychologist;Public Health;Recommendation;recruit;Regulation;Reporting;Research;Research Design;response;Safety;Sampling;school district;school shooting;Schools;Science;Scientist;Services;social;social media;Social Perception;stakeholder perspectives;Students;Suicide;Surveys;System;teacher;Technology;Texas;Time;trend;Update;Violence;Work;working group;Youth

PROJECT_TITLE: Stakeholder Perspectives on Social Media Surveillance in Schools


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Cancer;Ovarian Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_CITY: SAN DIEGO

ORG_DEPT: BIOLOGY

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: Narrative Ovarian cancer is usually diagnosed at a late stage when survival is only about 10%, rendering this disease the deadliest gynecological malignancy. Disease recurrence is the major cause of mortality and despite a greater understanding of ovarian cancer biology there have been no significant improvements in mortality rates in the last five decades. Investigation of tumor cells that are resistant to chemotherapy and have the capacity to regenerate tumors is crucial for achieving cures for ovarian cancer patients.

PI_NAMEs: HOUSE, CARRIE DANIELLE (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Address;Adjuvant Chemotherapy;Aftercare;aldehyde dehydrogenases;Cancer Biology;cancer cell;cancer drug resistance;Cancer Patient;cancer recurrence;Cancer Relapse;cancer survival;Carboplatin;Cell Physiology;Cell Survival;cell type;Cells;Chemoresistance;chemotherapy;Chemotherapy-Oncologic Procedure;Clinical;Clinical Data;Clustered Regularly Interspaced Short Palindromic Repeats;Combined Modality Therapy;cytokine;Cytotoxic agent;Cytotoxic Chemotherapy;Data;Death Rate;design;Development;Diagnosis;Disease;Disease remission;Disease Resistance;Drug resistance;Early identification;Ensure;Environment;Event;Experimental Designs;Family;Family member;Genes;Goals;Human;Imaging technology;Immunocompetent;improved;inhibitor;interest;Investigation;Knock-out;Knowledge;Macrophage;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Morbidity - disease rate;mortality;mouse model;Natural regeneration;Neoadjuvant Therapy;neoplastic cell;NF-kappa B;NF-kappaB-inducing kinase;notch protein;novel;ovarian neoplasm;Paclitaxel;Pathway interactions;Patients;Play;Population;Proliferating;Property;Publishing;Recurrence;Recurrent disease;Recurrent tumor;Relapse;Reporter;Reproducibility;Research;Resected;Resistance;response;Role;Sampling;self-renewal;Signal Pathway;Signal Transduction;Solid Neoplasm;standard of care;stemness;Stimulus;Stromal Cells;targeted treatment;therapeutically effective;Tissues;transcription factor;transcriptome sequencing;tumor;tumor initiation;tumor microenvironment;tumor progression;United States;Work;Xenograft procedure

PROJECT_TITLE: Alternative NF-kB activation in post-chemotherapy setting to elucidate novel mechanisms of ovarian cancer relapse

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Hematology;Infectious Diseases;Sepsis;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative Successful completion of the proposed studies will reveal a novel role of HDAC6 in the regulation of myeloid cell immune responses in sepsis. The studies will validate the therapeutic potential of HDAC6 inhibition to improve myeloid cell function in sepsis. The proposed studies will provide important information for future clinical trials.

PI_NAMEs: FU, JIAN  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Acetylation;Affect;alpha Tubulin;Apoptosis;Bacteria;Cell Differentiation process;Cell Physiology;Cell Survival;Cells;Clinical Trials;Cytoskeleton;Deacetylation;Development;Disease;Endotoxins;Epigenetic Process;Failure;Functional disorder;Future;Generations;Genetic Transcription;HDAC6 gene;Health;hematopoietic stem cell expansion;Histone Deacetylase;Immune;Immune response;Immune System Diseases;immunoregulation;improved;Infection;Inflammation;Inflammatory;Interferons;IRF1 gene;Life;Macrophage;Mediating;Mediator;Metabolic;Microtubule Stabilization;Microtubules;Modification;mortality;mouse model;Mus;Myelogenous;Myeloid Cells;Myeloid Progenitor Cells;Myeloid-derived suppressor cells;novel;Pathway interactions;Phenotype;Play;Regulation;Reporting;response;Role;Sepsis;septic;Signal Transduction;STAT1 gene;stem cells;Suppressor-Effector T-Lymphocytes;Survival Rate;Testing;Therapeutic;Therapeutic Effect;transcriptomics

PROJECT_TITLE: HDAC6 regulation of myeloid cell responses in sepsis


NIH_SPENDING_CATS: Biomedical Imaging;Childhood Obesity;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Digestive Diseases;Hepatitis;Liver Disease;Nutrition;Obesity;Pediatric;Prevention

PHR: PROJECT NARRATIVE The co-existence of prediabetes/T2D and NAFLD/NASH in obese youth are emerging as two major health challenges of the 21st century. This grant will provide mechanistic insights in support of a GLP-1 analogue, Liraglutide therapy for prediabetes, and NAFLD in youth.

PI_NAMEs: CAPRIO, SONIA  (contact)

PROGRAM_OFFICER_NAME: LINDER, BARBARA

PROJECT_TERMS: abdominal fat;active method;Adolescent obesity;Adult;Affect;Aftercare;Alleles;analog;arm;Beta Cell;blood glucose regulation;Body Composition;Cell Physiology;Clinical Trials Design;Closure by clamp;cohort;Coupled;Data;density;Diabetes Mellitus;Disease Progression;Double-Blind Method;Dual-Energy X-Ray Absorptiometry;Fatty acid glycerol esters;Fatty Liver;Fibrosis;Functional disorder;functional improvement;Funding;Genetic;Glucagon;glucagon-like peptide 1;Glucose;Glucose Clamp;glucose production;glucose tolerance;Glycerol;Grant;Health;Hepatic;Hyperinsulinism;impaired glucose tolerance;Impairment;improved;in vivo;inflammatory milieu;innovation;insight;Insulin;Insulin Resistance;insulin sensitivity;intrahepatic;intravenous glucose tolerance test;islet;Islet Cell;lipid biosynthesis;Lipolysis;liraglutide;Liver Fibrosis;liver imaging;Magnetic Resonance Elastography;Magnetic Resonance Imaging;Measurement;Measures;metabolic abnormality assessment;Metabolic Diseases;Metabolic syndrome;mimetics;Minor;Modeling;multi-ethnic;National Institute of Diabetes and Digestive and Kidney Diseases;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;novel strategies;Obesity;OGTT;Oral;Pathogenesis;pediatric non-alcoholic fatty liver disease;Pediatrics;Placebo Control;Placebos;Prediabetes syndrome;Predisposition;preservation;Prevalence;prevent;Protons;Randomized;Research Design;Risk;Role;Safety;Series;stable isotope;System;TCF7L2 gene;Techniques;Testing;Translational Research;Triglycerides;Variant;Withdrawal;Work;Youth

PROJECT_TITLE: Pathogenesis of youth onset pre-diabetes and Type 2 diabetes


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Narrative The ubiquitin E3 ligase, UBR5 is one of the most commonly mutated genes (~18%) in mantle cell lymphoma (MCL) with the majority of mutations identified in UBR5 were frame shift mutations found within the HECT domain. Here we will study the molecular function of ubiquitin E3 ligase, UBR5 mutations in lymphomagensis. Deciphering the role of the UBR5 and pathways dysregulated by mutations in mantle cell lymphoma will provide clues to lymphoma transformation with the goal of identifying targets for future therapeutics.

PI_NAMEs: BUCKLEY, SHANNON  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Alternative Splicing;B-Cell Activation;B-Cell Development;B-Cell NonHodgkins Lymphoma;B-Lymphocyte Subsets;B-Lymphocytes;Blood;Bodily secretions;C-terminal;Cell Cycle;Cell Maturation;Cell Physiology;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Complex;conditional mutant;Cysteine;Data;Defect;Development;Disease;Disease Progression;DNA Damage;drug discovery;effective therapy;Evolution;Frameshift Mutation;Functional impairment;Future;Genes;Genetic;Genetic Transcription;Goals;insight;knock-down;Lead;Length;lymph nodes;Lymphoid;Lymphoma;Lymphoma cell;Lymphomagenesis;Malignant Neoplasms;Mantle Cell Lymphoma;Mantle Zone;Messenger RNA;migration;Modeling;Molecular;mouse model;multicatalytic endopeptidase complex;Mus;mutant;Mutant Strains Mice;Mutate;Mutation;new therapeutic target;next generation sequencing;Non-Hodgkin's Lymphoma;Nonsense Codon;novel;overexpression;Pathogenesis;Pathway interactions;Patients;Phenotype;Plasma Cells;Population;Proliferating;protein degradation;protein expression;Protein Splicing;Proteins;Proteomics;Publishing;RNA Splicing;Role;Sampling;scaffold;Signal Transduction;Spleen;Spliceosomes;Structure of germinal center of lymph node;Survival Rate;System;Technology;Testing;Therapeutic;Therapeutic Agents;Therapeutic Intervention;therapeutic target;tool;tumor;Ubiquitin;ubiquitin-protein ligase;Up-Regulation

PROJECT_TITLE: Dissecting the Role Ubiquitin E3 Ligase UBR5 in Lymphomagenesis

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Individual hosts vary in their susceptibility to pathogens, which has important consequences for outbreak dynamics and pathogen evolution. Our work will elucidate relationships between prior exposure of hosts to pathogens, as occurs naturally and via vaccination, and the degree of variability in host susceptibility. The models generated will be broadly useful for understanding and managing any pathogens, including those of humans, where host protection generated by prior exposure is variable, incomplete, or wanes over time.

PI_NAMEs: HAWLEY, DANA M (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TITLE: Ecological and evolutionary causes and consequences of host heterogeneity induced by prior exposure


NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Development of strategies to identify inner retinal dysfunction in patients with retinitis pigmentosa, a progressive degenerative disease, will lead to a better understanding of the current limitations of, and potential opportunities for, treatments to restore visual function.

PI_NAMEs: HYDE, ROBERT  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Amacrine Cells;Animal Model;Animals;Area;Attenuated;Basic Science;Biological Markers;Blindness;career;career development;cell type;Cells;Characteristics;Chicago;Clinic;Clinical;Clinical Investigator Award;clinical practice;Complement;Coupling;Data;Deafferentation procedure;Dedications;Degenerative Disorder;design;Development;Doctor of Philosophy;effective therapy;Electrophysiology (science);Electroretinography;Environment;Ethics;Exhibits;experience;Fellowship;Frequencies;Functional disorder;functional improvement;Future;ganglion cell;Genetic;Goals;human subject;Illinois;Image;improved;indexing;Inherited;insight;Institution;Masks;Measures;Mediating;Mentors;Mentorship;Methods;mouse model;multidisciplinary;Mus;Nature;neural;Neurosciences;Noise;novel;Operative Surgical Procedures;Ophthalmology;Patients;Periodicity;pharmacologic;Pharmacology;photoreceptor degeneration;Photoreceptors;postsynaptic;prevent;Protocols documentation;Psychophysics;repaired;Research;research and development;Research Personnel;Research Training;response;Retina;Retinal Cone;retinal damage;Retinal Degeneration;Retinal Diseases;Retinal Ganglion Cells;retinal neuron;Retinitis Pigmentosa;Scientist;sight restoration;Signal Transduction;skills;Source;Standard Model;Stimulus;Structure of retinal pigment epithelium;success;Synaptic Potentials;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Time;Training;Training Programs;Translating;Translational Research;translational research program;transmission process;trial design;Universities;Vision;vision science;visual dysfunction;visual stimulus;Work

PROJECT_TITLE: Inner retinal dysfunction in retinitis pigmentosa


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Rare Diseases

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE The Human Phenotype Ontology (HPO) offers a computational bridge between genome biology and clinical medicine and is used across the globe for analysis and exchange of phenotype data in rare disease. The use of HPO is rapidly growing in academia and industry, including diagnostic laboratories, health software applications, and health-care delivery, and—with improvements, new capabilities, and wider community adoption—has significant potential to improve the diagnosis and treatment of many more genetic diseases. We propose to advance the HPO to meet this need and improve computational disease modeling in a cost-effective, community- supported initiative that will address an expanding set of medical disciplines.

PI_NAMEs: HAENDEL, MELISSA A;ROBINSON, PETER NICHOLAS (contact)

PROGRAM_OFFICER_NAME: MINEAR, MOLLIE A

PROJECT_TERMS: Academia;Acceleration;Address;Adopted;Adoption;Age of Onset;Algorithms;Automated Annotation;Basic Science;biobank;bioinformatics resource;Biology;biomedical ontology;Cardiology;Case Study;causal variant;Classification;Clinic;Clinical;clinical care;Clinical Data;clinical decision-making;Clinical Management;Clinical Medicine;cohort;Collaborations;Communities;community collaboration;Computational algorithm;Computer Analysis;Computer software;cost effective;Data;data exchange;Data Reporting;Development;Diagnosis;Diagnostic;diagnostic tool;Differential Diagnosis;Discipline;Disease;disease model;disease natural history;disease phenotype;Disparate;Electronic Health Record;Ensure;Event;experience;Face;Foundations;Frequencies;Genes;Genetic Diseases;genetic variant;Genome;genomic data;genomic variation;Genomics;Goals;Guidelines;Health;health care delivery;Human;human disease;Immunology;improved;Industry;International;interoperability;Intervention;Laboratories;Language;Link;Location;Maintenance;Malignant Childhood Neoplasm;Manuals;Maps;Medical;Medical Genetics;Modeling;Modernization;Nature;Nephrology;Neurology;Online Systems;Ontology;ontology development;Ophthalmology;patient registry;Patients;Performance;Pharmacogenomics;Phenotype;phenotypic data;precision medicine;Process;programs;Publishing;quality assurance;Rare Diseases;Research;Resources;Seizures;Sex Bias;Standardization;Structure;Terminology;Text;Time;Translations;user-friendly;Variant;variant of unknown significance;web portal

PROJECT_TITLE: The Human Phenotype Ontology: Accelerating Computational Integration of Clinical Data for Genomics

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Fibromyalgia;Interstitial Cystitis;Mental Health;Pain Research;Rehabilitation;Urologic Diseases

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: PROJECT NARRATIVE We seek to expand the portfolio of evidence-based treatments for urologic chronic pelvic pain syndrome (UCPPS) by evaluating the immediate and longer-term efficacy of a brief version of cognitive behavioral therapy (CBT) as well as the active ingredients (mechanisms) explaining why, how, and for whom it is most beneficial. An effective and relatively simple “across disorder” or transdiagnostic treatment that targets simultaneously what UCPPS and frequently co-occurring (and complicating) disorders have in common rather than their differences would improve on conventional behavioral pain approaches whose narrower focus, length, cost and/or complexity have limited their transfer from well-controlled laboratory to “real world” settings accessible to more individuals in need. By capitalizing on cutting-edge cognitive science research that emphasizes the importance of how patients think, not simply what they think about, we plan to demonstrate how a parsimonious, transdiagnostic, mechanistically-driven behavioral treatment of low intensity can reduce both painful urinary and co-occurring nonurological symptoms with minimal clinician oversight and maximum patient engagement, safety and benefit.

PI_NAMEs: LACKNER, JEFFREY M (contact)

PROGRAM_OFFICER_NAME: REYNOLDS, WILLIAM STUART

PROJECT_TERMS: Acute;Address;Affect;Aftercare;arm;Behavior Therapy;Behavioral;Behavioral trial;central pain;Chronic;Chronic Headaches;chronic pelvic pain;Chronic Prostatitis;Clinical;Cognition;Cognitive;cognitive process;Cognitive Science;Cognitive Therapy;comorbidity;coping;cost;COVID-19 pandemic;design;Development;Diagnosis;Diagnostic;Disease;Distress;economic cost;Education;Educational process of instructing;efficacy evaluation;endophenotype;evidence base;Evidence based treatment;Fatigue;Fibromyalgia;flexibility;Foundations;Functional impairment;Gender;Goals;Health;health related quality of life;Impairment;improved;Increased frequency of micturition;Individual;Informal Social Control;innovation;interdisciplinary approach;Interstitial Cystitis;Irritable Bowel Syndrome;Laboratories;Learning;Length;Maps;Mediating;Mediator;men;Mission;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;non-drug;novel;novel therapeutics;Outcome;Pain;pain catastrophizing;Pain management;pain patient;Pathway interactions;patient engagement;Patient Preferences;patient variability;Patients;Pelvic Pain;persistent symptom;personalized medicine;Phase;Phenotype;Policy Maker;Practice Guidelines;primary endpoint;Procedures;Process;prognostic indicator;Provider;provider adoption;Public Health;Race;Randomized;reduce symptoms;Research;Research Personnel;Resources;response;Safety;secondary endpoint;Self Management;Sensory;Severities;skills;social;Specificity;Statistical Models;symptom self management;symptomatic improvement;Symptoms;Syndrome;Techniques;Testing;Time;trait;treatment effect;treatment optimization;United States National Institutes of Health;uptake;urinary;urologic chronic pelvic pain syndrome;Woman;Work

PROJECT_TITLE: A BRIEF, TRANSDIAGNOSTIC COGNITIVE BEHAVIORAL TREATMENT FOR UROLOGIC CHRONIC PELVIC PAIN SYNDROME (UCPPS):  PROCESS, PREDICTIONS, OUTCOMES

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: DAVIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: NARRATIVE Positron emission tomography (PET) is a highly specific and sensitive imaging technique that visualizes molecular interactions, having a significant impact on biomedical research and translational medicine. This proposal develops high-performance and cost-effective time-of-flight PET detector modules based on the ultra- dense and fast ceramic scintillator. The proposed research will lead to next-generation PET scanners with superior performance and lower cost.

PI_NAMEs: KWON, SUN IL (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TITLE: High-performance and cost-effective detector modules based on ultra-dense and fast ceramic scintillator for long axial field-of-view positron emission tomography

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Rare Diseases;Stroke

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: GEORGETOWN UNIVERSITY

PHR: PROJECT NARRATIVE Loss of reading ability due to stroke, called alexia, likely affects over a million Americans at any given time and causes difficulty performing many daily life functions. Understanding the brain and cognitive basis of alexia could improve diagnosis and treatment of this important disorder, but modern methods and larger sample sizes are needed to address this gap in knowledge, along with an improved understanding of the brain and cognitive basis of reading in typical older adults in whom stroke is most common. In this project, we will perform a large- scale behavioral and brain imaging study of stroke survivors and typical older adults to improve our understanding of the brain and cognitive basis of reading in both of these groups.

PI_NAMEs: FRIEDMAN, RHONDA B;TURKELTAUB, PETER ETHAN (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: acute stroke;Address;Affect;Age;age related changes;Aging;aging brain;Alexia;American;Architecture;Area;Atlases;Behavior;Behavior Control;Behavioral;Brain;brain behavior;Brain imaging;Brain Mapping;Categories;Characteristics;Chronic;chronic stroke;clinical practice;Cognition;Cognitive;cognitive neuroscience;cohort;Compensation;Data;data modalities;Databases;Diagnosis;Diagnostic;Disease;Education;Free Will;Functional Magnetic Resonance Imaging;Goals;Hospitals;Image;imaging study;improved;injured;invention;Knowledge;Language;Language Tests;Left;Lesion;Life;loss of function;Magnetic Resonance Imaging;Maps;Materials Testing;Measures;Methods;Modeling;Modernization;multidisciplinary;multimodal neuroimaging;multimodality;neural patterning;Neurocognitive;neurocognitive test;neuroimaging;Neurosciences Research;novel strategies;older adult;Pathologic;Pathway interactions;Pattern;Performance;Persons;phonology;Population;Positioning Attribute;post stroke;Process;prospective;Reader;Reading;reading ability;reading difficulties;Recovery;Recovery Support;recruit;Research;Resources;restoration;Sample Size;Sampling;Semantics;Societies;Socioeconomic Status;Speech;speech processing;Stroke;stroke risk;stroke survivor;support network;Syndrome;System;Testing;Time;Translating;Vision;Work

PROJECT_TITLE: Brain networks for reading in stroke alexia and typical aging

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Training the next generation of physician-scientists who will tackle the important clinical issues in infectious disease and immunology requires a robust and innovative program to provide superb training on an integrated platform. We propose the Massachusetts General Hospital Next Generation Physician-Scientist Training Pathways program will provide dedicated research time to residents in the Departments of Medicine and Surgery to foster longitudinal mentorship, skill development, and perform high-quality research related to fundamental questions in infectious diseases and immunology.

PI_NAMEs: VYAS, JATIN M (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Address;Antimicrobial Resistance;apprenticeship;Area;Automobile Driving;Basic Science;Bioinformatics;Biomedical Research;Boston;career;Career Choice;Clinic;Clinical;clinical investigation;Clinical Medicine;Clinical Research;Clinical Skills;Communicable Diseases;Communication;Communities;cost effectiveness;Coupled;Dedications;design;Development;Development Plans;Educational process of instructing;Epidemiology;experience;Faculty;Failure;Fostering;Frustration;Funding;General Hospitals;Health;Health Care Research;HIV/AIDS;Hospitalists;Human;Immunology;Immunosuppressive Agents;improved;Individual;Infection;innovation;Inpatients;Institution;Intellectual Interest;interest;Internist;Investigation;Knowledge;Laboratories;Leadership;Learning;Massachusetts;Medical;Medical Education;medical schools;Medical Students;Medicine;Mentors;Mentorship;Methodology;Modeling;Morbidity - disease rate;mortality;National Institute of Allergy and Infectious Disease;next generation;Operative Surgical Procedures;Outcome;Participant;pathogen;Pathway interactions;Patient Care;Patients;Physicians;Play;preservation;Prevalence;Productivity;programs;Public Health;Readiness;Research;research and development;Research Personnel;Research Project Grants;Residencies;Role;role model;Science;Scientist;skill acquisition;skills;Source;statistics;Structure;success;Surgeon;symposium;Time;time use;Training;Translating;translational study;Transplantation;Transplantation Immunology;Work

PROJECT_TITLE: Pathways to Mentorship and Research: Training the Next Generation Physician-Scientists


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative Mechanisms that maintain genome stability have important relevance to human health and disease. We investigate these mechanisms systematically and at the molecular level to better understand genome editing technologies and cancer.

PI_NAMEs: ADAMSON, BRITTANY S. (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Address;cancer therapy;cell behavior;Cell Death;Cells;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Compensation;Comprehension;Data;deep sequencing;Disease;DNA;DNA Damage;DNA mapping;DNA Repair;DNA Repair Disorder;Ensure;experience;flexibility;functional genomics;Future;gene function;Genes;Genetic;Genetic Screening;Genome;genome editing;Genome Stability;Genomic approach;Goals;Health;Human;human disease;improved;Instruction;Knowledge;Lesion;Life;Logic;Malignant Neoplasms;Medical;Methods;Molecular;novel strategies;Organism;Pathway interactions;Pharmaceutical Preparations;Phenotype;programs;Prokaryotic Cells;repaired;Resolution;response;Signal Transduction;single-cell RNA sequencing;Streptococcus pyogenes;System;Techniques;Technology;tool;Work

PROJECT_TITLE: Mapping the DNA damage response in human cells with high-resolution functional genomics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: The Hawaiʻi Minority/Underserved NCORP aims to: 1) conduct cancer clinical trials and cancer care delivery research, 2) continue contributing to NCORP research bases and NCI priorities, and 3) enhance participation of Hawaii‘s diverse multiethnic and at risk population in NCI sponsored trials in order to reduce health care disparities and the burden of cancer for the people of Hawai‘i and elsewhere. !

PI_NAMEs: ACOBA, JARED  (contact);BERENBERG, JEFFREY LEE;BRAUN-INGLIS, CHRISTA

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: Address;Adolescent and Young Adult;Advocate;Asian Americans;base;Cancer Burden;cancer care;Cancer Center;cancer clinical trial;Cancer Control;cancer prevention;cancer therapy;care delivery;Caring;Chinese;Clinical Oncology;Clinical Trials;Communication;Communities;Community Clinical Oncology Program;cultural competence;data management;Decision Aid;Disease;Disparity;Elderly;Enrollment;ethnic minority;Ethnic Population;experience;Filipino;financial toxicity;Goals;Grant;Guam;Guideline Adherence;Hawaii;health care delivery;health care disparity;Health Personnel;Healthcare;Hospitals;Image;improved;Individual;Infrastructure;Institution;Intervention;Japanese;Koreans;Leadership;Lesbian Gay Bisexual Transgender;Lesbian Gay Bisexual Transgender Queer;low socioeconomic status;Malignant Neoplasms;Minority;Modality;multi-ethnic;Native Hawaiian;Oncologist;Pacific Islander;Patient-Focused Outcomes;Patients;personalized medicine;Persons;Physicians' Offices;Population;Populations at Risk;Prevention;Provider;Race;racial minority;racial minority population;Reduce health disparities;Research;Research Design;Research Infrastructure;Research Personnel;research study;Risk;Rural;screening;Sexual and Gender Minorities;Site;survivorship;Symptoms;Training;Underrepresented Populations;underserved minority;Underserved Population;Universities;University Hospitals;Work;working group

PROJECT_TITLE: The Hawaii Minority/Underserved NCORP


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Narrative This study will evaluate a drug that increases intestinal cell functions in mouse models of microvillus inclusion disease. The proposed treatment is expected to help broad intestinal deficits in malabsorption and diarrhea.

PI_NAMEs: KAJI, IZUMI  (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: absorption;Acceleration;Address;Agonist;Alkaline Phosphatase;Apical;apical membrane;Biological Assay;Body Weight decreased;Brush Border;Bypass;Cell Differentiation process;Cell Lineage;Cell Physiology;Cells;cellular microvillus;Child;Childhood;Chlorides;Cytomegalovirus Infections;Data;Defect;Diarrhea;diarrheal disease;Disease;dosage;drug efficacy;Electrophysiology (science);Energy Metabolism Pathway;Enterocytes;Epithelial Cells;Epithelium;Experimental Models;Family suidae;fatty acid oxidation;Functional disorder;gastrointestinal transplantation;Genetic Engineering;Glucose;Heterozygote;improved;In Situ;in vivo;Injections;intestinal crypt;intestinal epithelium;Intestinal Mucosa;Intestines;ketogenesis;Knock-out;Knockout Mice;Life;lipid biosynthesis;Lipids;Liquid substance;LoxP-flanked allele;lysophosphatidic acid;Lysophosphatidic Acid Receptors;Malabsorption Syndromes;mass spectrometric imaging;Mediating;Membrane Proteins;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Microvillus inclusion disease;Modeling;Motor;mouse model;Mus;mutant;Mutation;Myosin ATPase;Navajo;Nonmuscle Myosin Type IIA;Nutrient;nutrient absorption;nutrition;Oligo-1,6-Glucosidase;Organoids;Paneth Cells;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;Phospholipids;Point Mutation;polarized cell;Population;Proliferating;protein transport;Proteins;Protons;Receptor Activation;Reporting;self-renewal;Sensory;Signal Transduction;Sodium;Solubility;Specific qualifier value;stem cell differentiation;stem cell function;stem cells;stemness;Structure;Sucrose;symporter;Symptoms;Techniques;Therapeutic;therapeutic target;therapy development;Tissues;trafficking;transcriptome sequencing;Transgenic Mice;Transplantation;Villus;Water

PROJECT_TITLE: Impacting the pathophysiology of malabsorption induced by Myosin Vb inactivating mutations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DNPD-A(01)]


ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: In this proposal we will examine the role of post-transcriptional regulation of gene expression by microRNAs in antibody-mediated rejection of renal transplants.

PI_NAMEs: FAIRCHILD, ROBERT L;IACOMINI, JOHN J (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: Address;Affect;allograft rejection;Allografting;Antibodies;antibody-mediated rejection;Calcineurin inhibitor;Cells;Chronic;Clinical;clinical translation;clinically relevant;Communities;Complement;Complex;crosslink;Data;differential expression;digital;Disease;Event;Fibrosis;Gene Expression;Gene Expression Regulation;Genes;Graft Rejection;Human;Injury;Injury to Kidney;insight;integrin-linked kinase;interest;Kidney;kidney allograft;kidney cell;Kidney Failure;Kidney Transplantation;Knowledge;Maps;Mediating;member;Messenger RNA;MicroRNAs;miRNA expression profiling;mouse model;Mus;novel;Pathology;Pathway interactions;Play;Post-Transcriptional Regulation;Post-Translational Regulation;posttranscriptional;prediction algorithm;prevent;Process;Proteins;Regulation;renal damage;Reporting;Resources;response;response to injury;RNA;RNA-Binding Proteins;RNA-Induced Silencing Complex;Role;Sampling;Signal Pathway;Testing;Toxic effect;Transplantation;Untranslated RNA

PROJECT_TITLE: Post-transcriptional regulation of gene expression by microRNAs in antibody-mediated rejection

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ATHENS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Project Narrative Latinx children experience behavioral and physical health disparities early in development that persist into adulthood; it is not known how children’s physiological stress regulation relates to disparities in Latinx children or how Latinx caregivers can buffer their children from these negative outcomes. This proposal examines positive parenting as a buffer of the link between child physiological stress regulation and behavioral and academic adjustment during early childhood. The results will identify family and contextual factors that can be leveraged into culturally informed intervention programming to reduce disparities and improve the overall well- being of Latinx families.

PI_NAMEs: SUVEG, CYNTHIA M (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Address;Adult;Behavior;Behavior assessment;behavior observation;Behavioral;behavioral health;biobehavior;Biological;biological adaptation to stress;Biology;Buffers;Caregivers;caregiving;Child;Child Rearing;Chronic;Climate;Cognitive;contextual factors;COVID-19 pandemic;cultural values;culturally appropriate intervention;Data;Development;Discrimination;Disparity;disparity reduction;early childhood;Ensure;ethnic identity;executive function;expectation;experience;Face;Family;Fathers;Health;health disparity;Hispanic Populations;Hydrocortisone;improved;indexing;Informal Social Control;Intervention;kindergarten;Knowledge;Latina;Latinx;Latinx population;Legal Rights;Life Cycle Stages;Link;longitudinal design;Methods;minority health;minority health disparity;Modeling;modifiable risk;Mothers;Neurobiology;novel;Nursery Schools;Outcome;Parents;Patient Self-Report;peer;Personal Satisfaction;physical conditioning;Physiological;Physiology;Politics;Predisposition;Preschool Child;Process;Production;Productivity;prospective;Public Policy;Readiness;Recommendation;Reduce health disparities;Regulation;Research;Research Design;Research Personnel;respiratory;Risk;School-Age Population;Schools;Science;Self Assessment;Sinus Arrhythmia;skills;Skin;social;Social support;Stress;stress management;stressor;System;theories;Time;translational impact;United States National Institutes of Health;Work;Youth

PROJECT_TITLE: A culturally informed model linking physiological stress regulation and behavioral and academic adjustment in Latinx children

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-J(02)]


NIH_SPENDING_CATS: Aging;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Heart Disease;Mental Health;Post-Traumatic Stress Disorder (PTSD);Prevention;Sleep Research;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Cardiovascular disease (CVD) is the leading cause of death among women. Over one third of women report intimate partner violence (IPV) across the lifecourse, yet it is unclear if history of IPV increases women’s risk for CVD, particularly during midlife, a time of biological and psychosocial transition for women. This study will investigate the relationship of IPV to subclinical CVD in midlife women and will yield results that inform the development of interventions to improve cardiovascular health in women with trauma histories.

PI_NAMEs: JAKUBOWSKI, KAREN P (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Accidents;actigraphy;Adult;aged;Area;Arterial Fatty Streak;Behavioral;Biological;Blood Pressure;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;career;career development;Carotid Arteries;Carotid Artery Plaques;carotid intima-media thickness;Cause of Death;Child Abuse;Chronic;Chronic Disease;Chronic stress;Clinical;Cognitive;contextual factors;COVID-19 pandemic;critical period;Data;Development Plans;Dimensions;Disease Outcome;Ecological momentary assessment;emotional abuse;Event;Exposure to;Future;Glucose;Health;improved;indexing;Insulin;Interpersonal Relations;interpersonal trauma;Intervention;intimal medial thickening;intimate partner violence;Life;Life Cycle Stages;Link;Lipids;Measurement;Measures;Medicine;Mental Depression;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentorship;Methods;middle age;Midlife women;National Heart, Lung, and Blood Institute;Natural Disasters;Nightmare;Obesity;Outcome;Patient Self-Report;Peptide Initiation Factors;Persons;physical abuse;Physical activity;poor sleep;Population;Post-Traumatic Stress Disorders;Prevalence;psychosocial;Psychosocial Factor;Recording of previous events;recruit;Reporting;reproductive;Research;research and development;Research Personnel;Research Support;response;Risk;Risk Factors;Role;Sampling;Scientist;Sexual abuse;Sleep;sleep onset;sleep quality;Sleeplessness;Smoking;social;social determinants;Social Distance;Social Environment;Spouses;stay-at-home order;substance use;Surveys;Testing;therapy development;Time;Training;Trauma;trauma exposure;Trust;ultrasound;Vascular remodeling;vigilance;Violence;Woman;Women's Health;Women's mortality;Women's prevalence;Work;young woman

PROJECT_TITLE: Intimate Partner Violence and Subclinical Cardiovascular Disease in Midlife Women

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: Project Narrative Substantial disparities exist in childhood obesity and cardiovascular disease among racial and ethnic minorities and children from disadvantaged backgrounds. Despite availability of proven-effective interventions that aim to improve childhood obesity, substantial gaps remain in the adoption of recommended practices, particularly in settings that care for low-income children. The overall goals of this K24 application are to provide Dr. Elsie Taveras with protected time to perform equity-focused implementation research to accelerate the adoption of effective interventions to reduce childhood obesity and to train students, fellows, and junior faculty who wish to perform patient-oriented outcomes research in childhood obesity disparities.

PI_NAMEs: TAVERAS BENAVIDEZ, ELSIE MIREYA (contact)

PROJECT_TERMS: Acceleration;Adoption;Anthropometry;Area;Award;Body mass index;Cardiovascular Diseases;cardiovascular risk factor;care providers;career;Caring;Child;Childhood;Clinical Investigator;Data;Data Reporting;disadvantaged background;Disparity;Doctor of Philosophy;effective intervention;electronic health data;Electronic Health Record;Equity;ethnic disparity;ethnic minority;Evidence based practice;Faculty;Family;food insecurity;Fostering;Funding;General Hospitals;Goals;Grant;Guidelines;Health;health disparity;Healthcare Systems;housing instability;implementation evaluation;implementation research;implementation science;implementation study;improved;interoperability;Intervention;Low income;Massachusetts;Measures;medical schools;Mentors;Mentorship;minority children;Morbidity - disease rate;National Heart, Lung, and Blood Institute;Neighborhood Health Center;Neighborhoods;nutrition;Obesity;obesity in children;obesity management;obesity treatment;Outcome;Outcomes Research;Parents;patient oriented;patient oriented research;Patient-Focused Outcomes;Pediatric Hospitals;Pediatrics;pilot test;Population;Population Surveillance;Prevalence;prevent;primary care provider;primary care setting;Productivity;professor;programs;Public Health Schools;Quality of life;racial disparity;racial minority;Recommendation;Research;Research Personnel;Research Project Grants;research study;Risk;Risk Factors;Scientist;screening;social;Social Development;socioeconomic disparity;Specialist;student training;Subgroup;Testing;Time;Training;translational study;Transportation;United States Preventative Services Task Force;Weight maintenance regimen;Work;Youth

PROJECT_TITLE: Patient Oriented Research and Mentorship in Childhood Obesity Disparities


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Foodborne Illness;Genetics;Human Genome;Prevention

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: NARRATIVE Over one hundred million people worldwide consume arsenic-contaminated drinking water, which increases risk for a wide array of health conditions, including cancer. The goal of this project is to identify features of the human genome, both inherited and acquired, that reflect susceptibility to arsenic toxicity or response to arsenic exposure, using data from a large arsenic-exposed Bangladeshi cohort. Achieving these goals will reveal biological mechanisms of toxicity and susceptibility, identify potential targets for pharmacological intervention, and provide strategies for identifying high risk individuals and reducing their exposure.

PI_NAMEs: PIERCE, BRANDON LEE (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Arsenic;Arsenicals;Bangladesh;Bangladeshi;Behavior;Biological;Biological Markers;biomarker identification;cancer type;Cardiovascular Diseases;Chromosomal Loss;cohort;Consumption;contaminated drinking water;Data;Disease;DNA Methylation;drinking water;Environment;Environmental Health;Epidemiology;epidemiology study;epigenetic aging;Exposure to;Food Contamination;gene environment interaction;Genes;Genetic;genetic information;Genetic Predisposition to Disease;Genetic study;Genome;genome resource;genome wide association study;genome-wide;Genomics;global health;Goals;Health;Heritability;high risk population;Human;Human Genome;Individual;Inherited;Intervention;Knowledge;Length;life span;Malignant Neoplasms;Measurement;Metabolism;mitochondrial DNA mutation;Non-Malignant;novel marker;Outcome;Participant;Persons;pharmacologic;Point Mutation;Predisposition;Reproducibility;Research;Resources;Respiratory Disease;response;Risk;Role;Rural;skin lesion;Subgroup;Technology;telomere;Testing;Toxic effect;Variant;Work

PROJECT_TITLE: Arsenic and the Human Genome:  susceptibility and response to exposure