NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Pulmonary Fibrosis;Rare Diseases;Regenerative Medicine

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Viral respiratory infections, such as influenza and coronaviruses, frequently lead to acute respiratory distress syndrome (ARDS), a condition with a mortality up to 46% where up to half of survivors continue to suffer from chronic respiratory disability due to persistent pulmonary fibrosis. Endothelial injury and dysfunction contribute to the severity of ARDS, persistence of lung injury, and dysregulated repair. The proposed studies will elucidate how the pulmonary endothelium promotes repair of the closely associated alveolar epithelial layer after viral infection-induced lung injury and identify novel translational targets to prevent morbid post-viral fibrotic outcomes.

PI_NAMEs: BRAZEE, PATRICIA LOUISE (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: 2019-nCoV;3-Dimensional;Acute Respiratory Distress Syndrome;ADRBK1 gene;Alveolar;Alveolar Cell;alveolar epithelium;Attenuated;Award;Back;Biology;Blood Vessels;BMP2 gene;career;Cell Communication;Cell surface;Chronic;Coculture Techniques;Coronavirus;defined contribution;Degradation Pathway;Development;disability;disease model;Endothelial Cells;Endothelium;Epithelial Cells;epithelial repair;Epithelium;epithelium regeneration;Fibrosis;fibrotic lung disease;Foundations;Functional disorder;Funding;Future;G Protein-Coupled Receptor Signaling;Goals;Health;Human;human disease;human model;In Vitro;in vivo;in vivo Model;Inflammation;Influenza;Influenza A virus;influenza infection;Injury;Interruption;Intervention;Lead;Link;loss of function;Lung;lung injury;lung repair;Mediating;Molecular Biology Techniques;mortality;mouse model;Mus;novel;Organoids;Outcome;overexpression;Pathway interactions;pharmacologic;Phosphorylation;prevent;Production;Productivity;programs;Pulmonary Fibrosis;receptor;Recycling;Regulation;repaired;Research;Research Personnel;Resolution;respiratory;Role;Severities;Signal Transduction;single-cell RNA sequencing;skills;Slice;Solid;Sphingosine-1-Phosphate Receptor;Survivors;System;Testing;Therapeutic;therapeutic target;tissue repair;trafficking;Training;translational model;translational scientist;Up-Regulation;Viral;Viral Respiratory Tract Infection;Virus Diseases

PROJECT_TITLE: Endothelial S1PR1 promotes lung repair in post-viral ARDS

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-A (M1)]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: Athens

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: OSTEODX INC.

ORG_STATE: OH

PHR: Project Narrative This administrative supplement will fund development of regulatory plans in support of the commercialization of OsteoDx’s Cortical Bone Mechanics Technology (CBMT) that is being developed and validated by parent grant NIA R44AG058312. The parent grant is developing and validating the clinical utility of our novel osteoporosis related diagnostic device that non-invasively measures the mechanical properties of cortical bone and provides direct information about bone strength and quality that is not accessible by other diagnostic modalities.

PI_NAMEs: CLARK, BRIAN C;DICK, ANDREW  (contact)

PROGRAM_OFFICER_NAME: FOX, JENNIFER THERESA

PROJECT_TERMS: Administrative Supplement;Award;bone quality;bone strength;Businesses;Clinical;commercialization;cortical bone;design;Development;Diagnosis;Diagnostic;Diagnostic Equipment;Enhancement Technology;Funding;Grant;Intellectual Property;Market Research;Measures;mechanical properties;Mechanics;Medical Device;Modality;novel;Osteoporosis;parent grant;Phase;product development;Production;programs;Risk;Safety;Sales;Small Business Innovation Research Grant;Technology;Validation;Work

PROJECT_TITLE: Development of Cortical Bone Mechanics Technology for Enhancing the Diagnosis of Osteoporosis


ADMINISTERING_IC: HD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Human Genome;Infertility;Women's Health Research

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative Understanding the necessary genetic components is important for deciphering the causes of infertility and designing new contraceptives. I have identified several new genes involved in fertilization in the Caenorhabditis elegans model system. This work will establish new genes involved in fertilization on the oocyte surface.

PI_NAMEs: MANIATES, KATHERINE ANN (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Acceleration;Adult;Advisory Committees;Animals;Award;Binding;Biochemical;biochemical tools;Biochemistry;Biological;Biological Models;Caenorhabditis elegans;career;career development;causal variant;Cell Communication;Cells;Chromosomes;Clinic;Clinical;Complex;Congenital disorders of glycosylation;Contraceptive Agents;contraceptive target;Couples;CRISPR/Cas technology;Data;deep learning;Defect;design;egg;Embryo;Embryonic Development;experience;Faculty;Female;Fertility;Fertilization;follow-up;Funding;Funding Mechanisms;Future;Gene Activation;gene discovery;gene function;Generations;Genes;Genetic;genetic approach;Genetic Identity;Genetic Screening;Genome;genome analysis;genome sequencing;Germ Cells;Germ Lines;glycosylation;Goals;Homologous Gene;Human;human model;implantation;Infertility;infertility treatment;infrastructure development;Label;Learning;Mammals;Mediating;Mentors;Microscopy;Modeling;Molecular;Morphology;Mus;Mutagens;mutant;Mutation;new technology;Oocytes;Organism;Orthologous Gene;Phase;Phenocopy;Phenotype;pleiotropism;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;Process;programs;Proteins;Reiterated Genes;reproductive;Reproductive Biology;Research;research and development;Research Personnel;Resources;Role;Side;skills;sperm cell;Sterility;Structure;superresolution microscopy;Surface;System;Therapeutic Intervention;Time;tool;Training;Universities;Validation;whole genome;Work;zygote

PROJECT_TITLE: Role of PGM-3 and SPE-56 in fertilization and egg activation

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biomedical Imaging;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative Diffusion magnetic resonance imaging (dMRI) plays a crucial role in routine clinical neuroimaging and has shown potential in new applications ranging from detecting microstructural lesions to guiding neurosurgery. This project addresses the need to improve the performance of dMRI by enabling high-resolution microstructure imaging with fast acquisition times, allowing clinical translation of impactful research applications. Ultimately, the proposed approach has the potential to enhance the quality of care for individuals with neurological disorders.

PI_NAMEs: COELHO, SANTIAGO  (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: Acceleration;Accounting;Address;Affect;Algorithms;American;Award;Biological;Biophysics;blind;Brain;Brain imaging;Brain Stem;career;Clinic;Clinical;clinical application;clinical translation;Complex;Data;data acquisition;data modeling;Data Set;data space;design;Diagnosis;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;disease diagnosis;Disease Progression;Glioma;Goals;gray matter;high dimensionality;high resolution imaging;Image;image reconstruction;imaging approach;imaging modality;Imaging technology;improved;in vivo;Individual;innovation;Ischemia;Joint repair;Joints;Lesion;Magnetic Resonance Imaging;Maps;medical schools;Mentorship;Methods;millimeter;Modeling;Motion;MRI Scans;Multiple Sclerosis;multiple sclerosis patient;National Institute of Biomedical Imaging and Bioengineering;Nature;Nervous System Disorder;neuroimaging;neurosurgery;New York;novel;novel strategies;Patients;Performance;Phase;Physiologic pulse;Play;prevent;Process;progression marker;Property;Protocols documentation;Quality of Care;reconstruction;Reproducibility;Research;research clinical testing;Resolution;Role;Sampling;Scanning;Scheme;Severity of illness;Signal Transduction;skills;Speed;Structure;Surrogate Markers;Techniques;Testing;Time;Tissue Viability;Tissues;Training;Translating;Universities;Validation;water diffusion;white matter;white matter damage;Work

PROJECT_TITLE: Fast High-Resolution Microstructure Diffusion MRI Exploiting Data Redundancy

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-E (M1)]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Liver Disease;Lung;Lung Cancer;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSURGERY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Small cell lung cancer (SCLC) is a recalcitrant cancer that causes 250,000 deaths worldwide each year. When diagnosed, many patients have metastasis in distant organs, most often in the liver, which represents a major impediment to successful therapy. Through decrypting the reciprocal interactions between cancer cells and endothelial cells in SCLC liver metastasis, I aim to identify novel aspects of SCLC metastasis and nominate candidate avenues for target therapies for SCLC patients.

PI_NAMEs: TANG, RUI  (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: Angiogenesis Inhibitors;anti-cancer research;Automobile Driving;cancer cell;Cancer Etiology;Cancer Patient;cancer type;Candidate Disease Gene;career;Cell Communication;Cell Culture System;cell motility;Cell Physiology;Cell Surface Proteins;cell type;Cells;Cessation of life;chemokine;Clinic;Clinical;Clonal Expansion;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;CRISPR screen;CXCL1 gene;Cytotoxic Chemotherapy;Data;Dedications;delivery vehicle;Diagnosis;differential expression;Disease Resistance;Disseminated Malignant Neoplasm;Distant;Endothelial Cells;Environment;Exposure to;Family;Future;Gene Expression Alteration;Gene Expression Profile;Gene Mutation;Genes;Genetically Engineered Mouse;genome editing;Genotype;Human Cell Line;IL8RB gene;In Vitro;in vivo;inhibitor;innovation;insight;Isogenic transplantation;Liver;lung cancer cell;Malignant neoplasm of lung;Malignant Neoplasms;Mentors;Metastatic Neoplasm to the Liver;Methodology;Methods;Modeling;Molecular;mouse model;Mus;Neoplasm Metastasis;new therapeutic target;Normal Cell;novel;novel therapeutics;Oncogenes;Organ;Patients;Phase;Play;Population;Positioning Attribute;post-doctoral training;prevent;Proliferating;Relapse;Research;Role;sequencing platform;Signal Transduction;single-cell RNA sequencing;small cell lung carcinoma;Statistical Data Interpretation;System;targeted treatment;Techniques;Testing;Therapeutic;therapy resistant;three dimensional cell culture;Tomatoes;Touch sensation;Training;transcriptome sequencing;transplant model;Transplantation;tumor;tumor barcoding and sequencing;Universities;Xenograft procedure

PROJECT_TITLE: Dissecting reciprocal interactions between cancer cells and endothelial cells in SCLC liver metastasis.

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Diabetes;Eye Disease and Disorders of Vision;Health Services;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: DURHAM

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Diabetic retinopathy is one of the leading causes of irreversible blindness in the United States and decreasing this public health burden relies on timely screening and early intervention when needed. This project aims to understand the relationship between area deprivation index (ADI), as well as other measures of the local healthcare environment, and screening, follow up, and complication rates of diabetic retinopathy. Analyses will be conducted using 100% Medicare claims data, ADI and its components, and local healthcare environment information.

PI_NAMEs: BORKAR, DURGA  (contact);HAMMILL, BRADLEY G

PROGRAM_OFFICER_NAME: LE, JIMMY TOAN

PROJECT_TERMS: Academy;Adherence;American;Area;beneficiary;Blindness;care costs;Caring;Characteristics;Communities;Community Health;Complication;Complications of Diabetes Mellitus;cost;Data;deprivation;Development;diabetes management;Diabetes Mellitus;Diabetes prevention;Diabetic Retinopathy;Diagnosis;Early identification;Early Intervention;early screening;Education;Educational Status;Employment;Environment;Event;follow-up;Geographic Locations;Geography;Goals;Growth;Guidelines;Health Care Costs;health care quality;health data;health equity;Health Resources;Healthcare;Housing;improved;Incentive Reimbursement;Incidence;Income;indexing;Individual;individual patient;Institution;Insurance Coverage;Link;Measures;Medicare;Medicare claim;Modeling;Monitor;neighborhood disadvantage;Neighborhoods;Neovascular Glaucoma;Operative Surgical Procedures;ophthalmic examination;Ophthalmologist;Ophthalmology;Outcome;patient population;Patient-Focused Outcomes;Patients;Pattern;Persons;Population;Prevalence;Prognosis;proliferative diabetic retinopathy;Public Health;Race;Recommendation;Resource Allocation;Retinal Detachment;Risk;screening;screening guidelines;Social Environment;societal costs;Socioeconomic Factors;Time;Traction;tv watching;United States;Vision;vision development;Visual;Vitreous Hemorrhage;Work

PROJECT_TITLE: The Path to Improving Diabetic Retinopathy Outcomes: Evaluating Neighborhood Characteristics and Healthcare Quality

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The dramatic increase in early onset breast cancer (BC) incidence in the U.S., which has been most pronounced in non-Hispanic Black (NHB) women, underscores the need for an investment in cancer prevention research that is focused on risk modification beginning early in life. Increasing adolescent physical activity through community and family-based interventions may be one key factor in reducing early onset BC risk and racial disparities, but there is currently limited epidemiologic data, especially from racially diverse cohorts, to support this. This study will address this major gap by using data from racially diverse family-based cohorts that are enriched for BC susceptibility to elucidate the role of adolescent physical activity in early onset BC risk and outcomes after diagnosis in young women across the BC risk continuum and provide mechanistic insight that is needed to move this promising avenue for BC prevention and health equity forward.

PI_NAMEs: KEHM, REBECCA D (contact)

PROGRAM_OFFICER_NAME: WOLFF-HUGHES, DANA L

PROJECT_TERMS: Accelerometer;Address;Adolescence;Adolescent;Adult;adverse outcome;Affect;Age;Award;Biological Markers;Black race;black women;Body Composition;Body Size;Breast;breast cancer diagnosis;breast cancer family;Breast Cancer Prevention;Breast Cancer Risk Factor;Cancer Etiology;cancer prevention;cancer risk;cancer subtypes;Carcinogens;career;career development;case control;Case/Control Studies;cohort;Color;Communities;Coupled;Data;Development;Diagnosis;digital;early onset;emerging adult;epidemiologic data;Ethnic Origin;Evaluation;evidence base;Family;Family Cancer History;Female Adolescents;Genetic;genetic epidemiology;girls;Goals;Habits;health equity;health inequalities;Hispanic;Hispanic Women;Hormones;Incidence;insight;Intervention;Interviewer;Investments;Life;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammography;Measures;Mediation;Mendelian randomization;Metabolic;Metabolic Marker;Methods;Modeling;Modification;Molecular Epidemiology;molecular subtypes;mortality;multi-ethnic;Newly Diagnosed;Not Hispanic or Latino;novel;older women;Onset of illness;Optics;Outcome;parity;Phase;Physical activity;physical inactivity;Play;Population;Predisposition;Prevention Research;Prognosis;programs;prospective;public health priorities;Questionnaires;Race;racial disparity;racial diversity;Recurrence;Reporting;Research;Research Design;Risk;Risk Factors;Role;routine screening;Sampling;screening;Siblings;Spectrum Analysis;Statistical Methods;Surveys;Testing;therapy design;Time;tissue biomarkers;Training;trend;tumor;tumorigenesis;Undifferentiated;Woman;women's diagnosis;young woman

PROJECT_TITLE: Characterizing the role of adolescent physical activity in early onset breast cancer risk for women across the familial risk continuum


NIH_SPENDING_CATS: Breast Cancer;Cancer;Digestive Diseases;Immunotherapy;Liver Disease;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Most breast cancer-related deaths are the result of metastatic disease, and yet, some deadly metastatic sites, such as the liver, remain understudied. The project proposed in this application will improve the understanding of breast cancer liver metastasis by assessing the impact of tumor cell heme metabolism on immune suppression within the liver metastatic microenvironment. The goal of this research is to reveal novel therapeutic approaches to enhance anti-tumor immune responses against breast cancer liver metastasis and improve the survival and quality of life of breast cancer patients.

PI_NAMEs: WILLIAMS, MICHELLE M (contact)

PROJECT_TERMS: Address;aggressive breast cancer;Animals;anti-tumor immune response;Antigen Presentation;Bilirubin;Biological Assay;Biology;Blocking Antibodies;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Patient;Cancer Etiology;cancer recurrence;career;Cell Physiology;Cell secretion;Cells;Cessation of life;Clinical;Colorado;Conditioned Culture Media;cytokine;cytotoxic;Data;Death Rate;Disease;Enzymes;exhaust;Faculty;Foundations;Funding;Genetic;Genetic Transcription;Glucose;Glycolysis;Goals;Heme;heme oxygenase-1;Hepatocyte;High Prevalence;Human;hypoxia inducible factor 1;Immune;Immune checkpoint inhibitor;Immune response;Immunity;Immunosuppression;Immunotherapy;improved;in vivo;Institution;Knowledge;knowledge base;Kupffer Cells;Liver;Liver diseases;liver function;Macrophage;Malignant Breast Neoplasm;Mediating;Medical;Mentors;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Metastatic breast cancer;Metastatic Neoplasm to the Liver;Metastatic Neoplasm to the Lung;Modeling;mortality;Mus;Neoplasm Metastasis;neoplastic cell;novel;novel strategies;novel therapeutic intervention;Organ;overexpression;Paper;Pathway interactions;Patients;PD-1/PD-L1;pharmacologic;Phase;Postdoctoral Fellow;Procedures;Production;programmed cell death ligand 1;programmed cell death protein 1;programs;Quality of life;Regulation;Regulatory T-Lymphocyte;Research;Resistance;response;Shapes;Site;skills;small hairpin RNA;Specimen;success;Support System;Supporting Cell;T-Lymphocyte;tenure track;Testing;Time;Tissues;Training;triple-negative invasive breast carcinoma;tumor;Tumor Immunity;tumor immunology;tumor metabolism;United States;Universities;Up-Regulation;Women's mortality;Work

PROJECT_TITLE: Targeting heme metabolism to initiate an immune response against breast cancer liver metastasis


NIH_SPENDING_CATS: Cancer;Climate-Related Exposures and Conditions;Genetics;Skin Cancer

ORG_CITY: AUGUSTA

ORG_DEPT: PATHOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative The proposed research will investigate the mechanism by which production of GTP by GTP biosynthetic enzymes promotes activity of the tumor-promoting protein Rac1 in melanoma, and seek to exploit this mechanism for potential Rac1-suppressing therapy. Evaluating this approach could have an impact on aggressive melanoma cases which contain a prevalent Rac1 mutation, while also providing a basis for pursing novel treatments in other Rac1-dependent cancers. This work will also expand our understanding of the regulation of Rac1 by GTP metabolism by using state-of-the-art technology, providing new insights into the functionality of this critical protein in both normal and malignant cells.

PI_NAMEs: WOLFF, DAVID W (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Actins;Adopted;Affect;Area;Binding;Biosensor;cancer cell;Cells;Clinical;clinically relevant;clinically significant;cofactor;Collaborations;Communication;Data;Dependence;Disease;Dissociation;Dose;Drug resistance;efficacy evaluation;enzyme biosynthesis;Enzymes;factor A;Feedback;Fluorescence Resonance Energy Transfer;gain of function;gain of function mutation;Gene Expression;gene induction;Genetic;Growth;GTP Binding;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;High Pressure Liquid Chromatography;Human;Hydrolysis;imaging study;Immune response;Immunosuppression;inhibitor;Inosine Monophosphate;insight;Invaded;kinase inhibitor;Laboratories;Malignant Neoplasms;Measures;Mediating;Melanoma;Melanoma Cell;Mentors;Metabolism;Metastatic Melanoma;meter;Methods;Mitogen-Activated Protein Kinase Inhibitor;Mitogen-Activated Protein Kinases;Modeling;mouse model;Movement;multiplexed imaging;Mus;Mutation;myocardin;Nature;Neoplasm Metastasis;Normal Cell;novel;Nucleotides;Oncogenic;Oncoproteins;Oxidoreductase;Patients;pharmacologic;Phenotype;pre-clinical;Production;Prognosis;Proteinase 3;Proteins;Publishing;Regulation;Reporting;Research;Resistance;rho GTP-Binding Proteins;Ribavirin;Role;Series;Serum Response Factor;spatiotemporal;standard of care;Structure;Sun Exposure;Technology;Testing;Therapeutic;Time;tool;transcription factor;Transcriptional Regulation;tumor progression;Tumor Promotion;Visualization;Work;Xenograft procedure

PROJECT_TITLE: Interrogating the role of GTP metabolism in Rac1-driven phenotypes in melanoma


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Colorectal Cancer;Digestive Diseases

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: PROJECT NARRATIVE This proposal focuses on the development of a novel surface enhanced spatially offset resonance Raman spectroscopy (SESORRS) endoscope for the imaging and evaluation of colorectal cancer (CRC). Current clinical practices for the endoscopic imaging of CRC provide only morphological information, often failing to efficiently evaluate the required circumferential resection margin, or extent of tumor invasion into the wall of the colon. We aim to show that it is possible to use SESORRS endoscopy to determine the true extent of tumor invasion in real time, and use SESORRS endoscopy to support the image guided resection of lesions of interest by detecting residual tumor cells on, and beneath, the surface of the resection bed.

PI_NAMEs: NICOLSON, FAY  (contact)

PROGRAM_OFFICER_NAME: DELLAZANNA, GARY

PROJECT_TERMS: 3-Dimensional;Address;anatomic imaging;Animal Model;Area;Award;Beds;Biodistribution;Biological Markers;Cancer Biology;cancer genetics;cancer imaging;career;Cause of Death;Cell surface;Characteristics;Chemicals;Clinical;clinical practice;clinical translation;Collection;Colon;Colorectal Cancer;colorectal cancer treatment;Contrast Media;Dana-Farber Cancer Institute;design;Detection;Development;Diagnosis;DNA Sequence Alteration;Dose;Drug Kinetics;Endoscopes;Endoscopy;Evaluation;Excision;experience;Fiber;Fiber Optics;Goals;Histology;Image;image guided;image processing;imaging agent;imaging approach;imaging modality;imaging probe;Imaging Techniques;improved;in vivo;in vivo optical imaging;interest;Invaded;KRASG12D;Large Intestine;Lead;Lesion;Light;Magnetic Resonance Imaging;Malignant Neoplasms;Membrane Proteins;Mentors;method development;Microscopic;migration;Modeling;molecular imaging;Molecular Target;Morphology;mouse model;neoplastic cell;novel;Operative Surgical Procedures;optical imaging;Optics;Outcome;patient prognosis;patient stratification;Phase;Photons;Positron-Emission Tomography;preclinical study;Principal Investigator;Proteins;Proteomics;Qualifying;Radiochemistry;Radiolabeled;radiotracer;Raman Spectrum Analysis;real-time images;Reproducibility;Research;Research Personnel;Residual Neoplasm;Residual state;screening;skill acquisition;skills;Specificity;Specimen;spectroscopic imaging;Staging;success;Surface;Testing;Time;Tissues;Training;treatment group;tumor;Tumor Cell Invasion;Writing

PROJECT_TITLE: SESORRS endoscopy for the staging and evaluation of colorectal cancer


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Neurosciences;Prevention;Women's Health Research

ORG_CITY: TUCSON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: The proposed research is relevant to public health because it represents a novel way to combine cognitive science research techniques with radiological imaging to determine from neural and oculomotor analyses the extent to which the detection of one cancer impacts the detection of an additional cancer. It will also assess the impact that tomosynthesis, compared to mammography, and expertise has on multiple-abnormality miss rates in breast cancer detection. Thus, the proposed research is relevant to the part of the NIH’s mission that aims to reduce illness and lengthening life by improving early cancer detection.

PI_NAMEs: ADAMO, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: WU, YICONG

PROJECT_TERMS: 3-Dimensional;Address;Affect;Attention;attentional bias;Breast Cancer Detection;breast imaging;Cancer Detection;cancer diagnosis;cancer imaging;Cognitive;Cognitive Science;Data;Detection;Digital Breast Tomosynthesis;Digital Mammography;Educational workshop;Electroencephalography;Goals;Grant;Image;Imaging technology;improved;innovation;Institution;Knowledge;Life;Malignant Breast Neoplasm;Malignant Neoplasms;Mammography;Medical Imaging;meetings;Memory;mental representation;Mentors;Methodology;Methods;Mission;Modality;Multiple Abnormalities;neural;neuromechanism;novel;oculomotor;Outcome;Public Health;radiological imaging;radiologist;Radiology Specialty;Research;Research Personnel;Research Technics;satisfaction;Screening for cancer;Screening procedure;Short-Term Memory;Techniques;Testing;Three-Dimensional Image;Three-Dimensional Imaging;Time;tomosynthesis;Training;United States;United States National Institutes of Health;virtual;Visual;visual tracking;Woman;women's diagnosis;Work

PROJECT_TITLE: Cognitive Science to Radiology: Using EEG and Eye-tracking to Determine Why, How, and When Novices and Radiologists Miss Signs of Breast Cancer in Multiple-abnormality Mammography and Tomosynthesis


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Digestive Diseases;Immunization;Immunotherapy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Many anti-cancer drugs are ineffective in solid tumors, but the underlying mechanism is not fully understood. This proposal aims to identify the factors in the tumor microenvironment that drive drug resistance in pancreatic cancer by integrating single-cell drug imaging and spatial multi-omics. This project will result in computational tools to chart the spatial landscape of the cell-cell and drug-cell interactions within the tumor microenvironment, revolutionize our understanding of the drug resistance mechanisms in pancreatic cancer, and facilitate the development of new treatment strategies to improve patient outcomes with this devastating disease.

PI_NAMEs: LU, GUOLAN  (contact)

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: Academic Training;Advisory Committees;anti-PD-L1 antibodies;Antibodies;Antibody Binding Sites;Antibody Therapy;Antibody-drug conjugates;Antineoplastic Agents;Architecture;Automobile Driving;cancer cell;Cancer Detection;cancer surgery;cancer therapy;cancer type;career;career development;Career Mobility;Cell Communication;cell type;Cells;cellular imaging;Cetuximab;chemotherapy;Clinic;Clinical;clinical efficacy;clinical imaging;Clinical Research;Clinical Trials;Complex;computerized tools;Computing Methodologies;Cytotoxic T-Lymphocytes;Data;deep learning;Dendritic Cells;Development;Diagnosis;Disease;Dose;drug action;Drug Delivery Systems;Drug Interactions;Drug resistance;Encapsulated;Environment;Epidermal Growth Factor Receptor;Extracellular Matrix;Extracellular Matrix Proteins;Fibroblasts;fibrogenesis;first-in-human;Fluorescence;Goals;graduate student;Human;Image;imaging modality;imaging platform;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immunologics;immunoregulation;Immunosuppression;improved;insight;Intravenous;invention;Machine Learning;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;Measures;Mediating;Mentors;Mentorship;Methods;Molecular;Monoclonal Antibodies;mouse model;multiple omics;multiplexed imaging;Mus;novel;novel anticancer drug;novel therapeutic intervention;Operative Surgical Procedures;overexpression;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;panitumumab;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;Penetration;periostin;Pharmaceutical Preparations;Phase;Phenotype;Physicians;Play;Postdoctoral Fellow;preclinical efficacy;Predisposition;Primary Neoplasm;Program Development;programs;Research;Research Personnel;Research Project Grants;Resistance;resistance mechanism;Resolution;response;Role;Scientist;Shapes;Solid Neoplasm;spatial integration;Structure;T-Lymphocyte;Techniques;Technology;Testing;Therapeutic antibodies;Thick;Tissues;Training;transcriptomics;Transgenic Mice;tumor;tumor microenvironment;Tumor-associated macrophages;tumor-immune system interactions;uptake

PROJECT_TITLE: Integrating Spatial Omics and Drug Imaging to Dissect the Role of Pancreatic Tumor Microenvironment in Drug Resistance


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Hematology;Infectious Diseases;Lung;Orphan Drug;Rare Diseases

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Aspergillus is a common environmental fungus that can cause invasive pulmonary aspergillosis, a dangerous infection in patients with weakened immunity. We seek to understand the components of the immune system that help the body fend off this infection. This knowledge has the potential to lead to new treatments to protect patients from this devastating infection.

PI_NAMEs: CAGNINA, REBECCA ELAINE (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: adaptive immune response;adaptive immunity;Allergic Bronchopulmonary Aspergillosis;Antibodies;Aspergillosis;Aspergillus;Bronchoalveolar Lavage Fluid;career;CD4 Positive T Lymphocytes;Cell secretion;Cells;Clinical;Dangerousness;Data;Defect;Development;Disease;Exposure to;Funding;fungus;Future;Goals;Host Defense;Host Defense Mechanism;Human;human disease;human pathogen;IL17 gene;Immune response;Immune system;Immunity;Immunocompromised Host;immunodeficiency;Impairment;Individual;Infection;Innate Immune Response;innovation;Knowledge;Life;Lung;Lung Diseases;Lymphocyte;Mediating;Mediator;Memory;microbicide;Modeling;Molds;Mononuclear;mortality;mouse model;Mucous Membrane;Mus;Neutropenia;neutrophil;Neutrophil Infiltration;novel;novel therapeutics;Organism;pathogen;pathogenic fungus;Pathway interactions;Patients;Phagocytes;Play;Predisposition;Prevention strategy;Public Health;Reporting;Research Personnel;Respiratory Tract Infections;response;Role;Site;T memory cell;T-Cell Depletion;T-Lymphocyte;Testing;Tissues;Transgenic Mice;Translating;vaccine development;Work

PROJECT_TITLE: Adaptive immunity to Aspergillus during neutropenia

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-N (M1)]


NIH_SPENDING_CATS: Cancer;Kidney Disease;Rare Diseases

PHR: Project Narrative Clear cell renal cell carcinoma is the most common type of renal cell carcinoma which is characterized by a highly vascular tumor microenvironment and initially responds well to anti-angiogenic therapies. Despite this, almost all patients develop resistance to these therapies and thus improved therapies are urgently needed to treating patients affected by this disease. In this study, we propose utilizing a novel small molecule inhibitor and vaccine to target Profilin1 as a putative target for vascular normalization and treatment for renal cell carcinoma.

PI_NAMEs: GAU, DAVID MARTIN (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: Actin-Binding Protein;Actins;advanced disease;Affect;Agonist;angiogenesis;Angiogenesis Inhibitors;antagonist;Attenuated;Automobile Driving;Autophagocytosis;Bioenergetics;Biological Process;Biology;Blood Vessels;cell motility;Cell Proliferation;Cell secretion;Cessation of life;Clear cell renal cell carcinoma;Clinical;Cytoskeleton;Data;Deterioration;Disease;Endothelium;extracellular;Gene Expression;Genetic;Glycolysis;Goals;Growth;Human;Hypoxia;Immunologics;improved;In Vitro;in vivo;Kidney;Link;Malignant Epithelial Cell;Mediating;Mediator;Mentors;Microvascular Permeability;Mitochondria;Molecular Target;Neoplasms in Vascular Tissue;neoplastic cell;normoxia;novel;Outcome;overexpression;paracrine;Paracrine Communication;Pathologic;patient prognosis;Patients;Perfusion;Pharmaceutical Preparations;Phenotype;Physiological;Play;polymerization;Polymers;Process;profilin;profilin 1;receptor;Refractory Disease;Regulation;Renal Carcinoma;Renal Cell Carcinoma;Resistance;Resistance development;Respiration;Rest;Retina;Role;Signal Transduction;small molecule;small molecule inhibitor;targeted treatment;Testing;Therapeutic;therapeutic target;therapy outcome;therapy resistant;Training;treatment strategy;tumor;Tumor Cell Migration;tumor microenvironment;tumor progression;Tumor Promotion;tumor-immune system interactions;tumorigenic;ultrasound;Vaccines;Vascular Endothelial Cell;Vascular Endothelial Growth Factors;Vascularization;virtual

PROJECT_TITLE: Profilin as a Novel Target for Vascular Normalization in Renal Cancer


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Clinical Research;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Metastatic relapse can occur 20 years or more after diagnosis in patients with breast cancer. Developing therapies to prevent late recurrence and predict patients that will eventually relapse remains an enormous clinical challenge due to the lack of basic understanding of breast cancer cell dormancy in the bone marrow, the putative source of relapse. This proposal seeks to investigate the contribution of the bone marrow microenvironment to the induction and maintenance of dormancy via development of a novel mouse and biomaterial models and analysis of patient bone marrow biopsies.

PI_NAMEs: BUSHNELL, GRACE GILMORE (contact)

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: Antibodies;Award;Biocompatible Materials;Bioinformatics;Biological Assay;biomarker identification;Biopsy;Biopsy Specimen;Blood Vessels;bone;Bone Marrow;Bone marrow biopsy;Bone Marrow Cells;Bone Marrow Stem Cell;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;Cancer Biology;cancer cell;cancer stem cell;Cause of Death;Cell Communication;Cell Line;Cells;Classification;Clinical;Clinical Oncology;Coculture Techniques;Consult;Cues;Cytometry;Data;Development;Diagnosis;Elements;Estrogen receptor positive;Evaluation;Exhibits;experience;Gel;Hematopoietic;high dimensionality;high risk;Hormone Responsive;Hormones;human disease;Hydrogels;Image;Immune;Immunocompetent;In Vitro;in vivo;Inflammation;Learning;Life;Maintenance;Malignant Breast Neoplasm;Mechanics;mechanotransduction;Mentors;Microscopy;Modeling;Molecular Biology;mouse model;Mus;Nature;Neoplasm Metastasis;neoplastic cell;Normal tissue morphology;novel;Optics;Paracrine Communication;Pathology;Patients;Phase;Phenotype;Play;Population;predictive modeling;prevent;Prevention;Prognostic Factor;programs;Proliferating;protein biomarkers;recruit;Recurrence;Recurrent disease;Regulation;Regulatory Pathway;Relapse;Research;Risk;Role;Sampling;Series;single-cell RNA sequencing;Source;stem;stem cell niche;stemness;Stressful Event;Testing;therapeutic development;therapeutic target;therapy development;Three-Dimensional Imaging;tissue stem cells;Tissues;Training;tumor;Work

PROJECT_TITLE: Bone marrow niche regulation of disseminated tumor cell dormancy, reactivation, and metastasis.


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Microbiome;Prevention;Women's Health Research

ORG_CITY: Newark

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: PROJECT NARRATIVE This proposed project aims to identify specific compositional and functional features of gut microbiome that are directly involved in benign breast disease (BBD), and reveal the possible role of gut microbiome in mediating the hormonal risk factors-BBD risk association. This project will identify novel gut microbial and metabolomic markers that can advance future risk prediction of BBD, inform more effective microbiome-based interventions aimed at BBD risk reduction among high-risk women defined by their hormonal profiles, which ultimately will help reducing the growing burden of BBD and breast cancer-associated morbidity and mortality.

PI_NAMEs: WANG, TENGTENG  (contact)

PROGRAM_OFFICER_NAME: GEORGE, CHRISTINA DAWN

PROJECT_TERMS: 16S ribosomal RNA sequencing;Age;Age at Menarche;Applications Grants;Attention;Award;Bacteria;Bacteroides;Benign;Bioinformatics;biomedical scientist;Biopsy;Breast;Breast biopsy;Breast Cancer Epidemiology;Breast Cancer Prevention;Breast Diseases;breast pathology;Cancer Etiology;career;Catalogs;Classification;cohort;Collaborations;Collection;Data;Data Analyses;Data Set;Development;Diagnosis;disease diagnosis;disorder risk;disorder subtype;Environment;Epidemiology;Estrogens;Etiology;Event;Exogenous Hormone Therapy;experience;fecal microbiome;Feces;First Births;Fostering;Future;Goals;gut microbes;gut microbiome;gut microbiota;high risk;High Risk Woman;Homeostasis;Hormonal;Hormonal Risk Factor;Hormones;Hospitals;Human Microbiome;innovation;Knowledge;Lesion;Link;Liquid Chromatography;Malignant Breast Neoplasm;Measurement;Mediating;menopausal hormone therapy;Mentors;Metabolism;metabolome;metabolomics;metagenomic sequencing;Metagenomics;Methods;microbial;microbial community;microbial signature;microbiome;microbiome composition;microbiome research;microbiome therapeutics;microbiota;microbiota metabolites;Morbidity - disease rate;mortality;multidisciplinary;Multiomic Data;multiple omics;Nested Case-Control Study;novel;Nulliparity;Nurses;Nurses' Health Study;Oral Contraceptives;Participant;Pathogenesis;Pathologic;Pathologist;Pathology;Pathway interactions;Play;premalignant;Productivity;programs;Proliferative Type Breast Fibrocystic Change;prospective;Prospective Studies;Reporting;reproductive;Reproductive History;Research;Research Personnel;Retrospective Studies;Risk;Risk Factors;risk prediction;Risk Reduction;Role;sample collection;Sample Size;Shotguns;small molecule;stool sample;Strategic vision;tandem mass spectrometry;Taxonomy;Testing;Tissue Sample;Training;United States;Variant;Woman;Women's mortality;Women's study

PROJECT_TITLE: Identifying the role of the gut microbiome in the etiology of benign breast disease


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: JACKSON

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Project Narrative Triple negative breast cancer (TNBC), the most aggressive breast cancer subtype, affects about 20% of breast cancer patients and is disproportionately diagnosed in young, Black women. Researching how socio-structural determinants of health “above the skin” influence biological mechanisms “under the skin” could help to understand potential drivers of racial disparities in TNBC. This study focuses on how neighborhood-level redlining contributes to disparities in TNBC incidence through epigenetic changes and activation of oncogenic signaling pathways, leading to tumorigenesis.

PI_NAMEs: MILLER-KLEINHENZ, JASMINE  (contact)

PROGRAM_OFFICER_NAME: NELSON, STEFANIE A

PROJECT_TERMS: Address;Affect;aggressive breast cancer;Air Pollution;Area;Award;bead chip;beta catenin;biobank;Biological;black women;Breast Cancer Patient;cancer health disparity;cancer subtypes;Chronic;Communication;Data;Development;Diagnosis;didactic education;Disparate;Disparity;disparity reduction;DNA;DNA Methylation;DNA Sequence;Drug resistance;Education;Environment;Environmental Risk Factor;Epidemiology;Epigenetic Process;epigenome;Etiology;Exclusion;experience;Exposure to;Fostering;Gene Expression;Genes;Genetic Variation;Goals;Green space;Health;health determinants;health disparity;health equity;Healthcare;Hematology;Housing;Incidence;Inequity;Inflammation;Intervention;Investigation;Knowledge;Leadership;Learning;Life Style;Link;Location;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Measures;Mentors;Methylation;methylome;Molecular Epidemiology;mortality;Neighborhoods;Neoplasm Metastasis;neoplasm registry;nutrition;Oncogenic;Oncology;outcome disparities;Pathology;Pathway interactions;Pharmacological Treatment;Phase;Phenotype;Physical activity;Play;Policies;Population;Positioning Attribute;Prevalence;professional atmosphere;professor;programs;Psychosocial Stress;Public Health Schools;Publishing;racial difference;racial disparity;Reporting;Research;Research Personnel;Role;Sampling;Signal Pathway;Signal Transduction;Signaling Molecule;skills;Skin;social;social disparities;social epidemiology;social factors;social health determinants;social structure;Stress;structural health determinants;Structural Racism;Tissues;Tobacco smoke;Training;triple-negative invasive breast carcinoma;tumor;Tumor Biology;tumor DNA;Tumor Expansion;Tumor Subtype;Tumor Tissue;tumorigenesis;Universities;Variant;White Women;Woman;women's diagnosis;Work

PROJECT_TITLE: Investigating Socio-Structural Determinants of Health and the Tumor Epigenome to Understand the Etiology of Racial Disparities in Breast Cancer


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Palliative Care;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

PHR: PROJECT NARRATIVE Following changes in physical function and social roles and responsibilities after a cancer diagnosis, Asian Americans may self-perceive that they are a burden on family members, which is related to a lower quality of life and more distress and depression. Despite this, Asian American cancer patients utilize mental health services at lower rates than other groups and this may be due to a dearth of culturally-competent services. The goal of the project is to design and test the feasibility of two positive activity interventions, household contribution and outside contribution, intended to increase health-related quality of life in Asian American cancer patients by increasing a sense of relatedness, autonomy, and competence.

PI_NAMEs: SHIN-CHO, LILIAN J (contact)

PROGRAM_OFFICER_NAME: WEAVER, SALLIE JAYNE

PROJECT_TERMS: acceptability and feasibility;Affect;Age;American;Asian Americans;Award;Behavior;Behavioral;cancer care;Cancer Control;cancer diagnosis;cancer health disparity;Cancer Patient;cancer prevention;cancer therapy;Capital;Caregiver well-being;Caregivers;Cause of Death;Church;Cognitive;Collaborations;Communities;community based participatory research;comparison control;comparison intervention;Competence;Control Groups;cooking;cost;Country;cultural competence;Data;Dependence;design;Development;Diagnosis;Disparity;disparity elimination;Distant;Distress;Elements;Emotional;Environment;experience;family burden;Family Caregiver;Family member;feasibility testing;Feeling;follow-up;Friends;Fright;Goals;health disparity;health literacy;health related quality of life;Home;Household;Human Resources;improved;inclusion criteria;Individual;Intervention;intervention effect;Interview;Job loss;Language;Learning;Malignant Neoplasms;Mediating;Mediator;member;Mental Depression;Mental Health Services;Mentorship;Methods;Minority Groups;novel;Outcome;Participant;participant enrollment;Patients;perceived stress;Personal Satisfaction;Phase;Physical Function;physical symptom;Population;prototype;psychologic;Qualitative Research;Quality of life;Randomized;Reporting;Research;Research Personnel;Research Training;Role;Self Administration;Self Determination;Services;skills;social group;social relationships;Social Responsibility;social stigma;Social support;Structure;Testing;theories;therapy design;Thinking;Training;volunteer;Work

PROJECT_TITLE: Positive Activities for Asian American Cancer Patients and Caregivers


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Mental Health;Neurosciences;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Sleep Research

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Project Narrative Cancer and its treatment during adolescence or early young adulthood potentially disrupts normal frontal neurodevelopment leading to cognitive dysfunction; however, sparse research on cognition in this vulnerable population has relied primarily on self-report, with limited data on objective cognitive deficits. In this innovative study, we propose to implement objective cognitive assessment in real-time in survivors’ daily life and measure situational, behavioral, and contextual risk factors. By tailoring the assessment methodology to young adult survivors, collecting pilot feasibility and acceptability data, then conducting a large, case-controlled study of cognition in young adult survivors and matched non-cancer controls, we will provide much-needed data on the prevalence of long-term cancer-related cognitive impairment and how to alleviate this problem in this vulnerable population.

PI_NAMEs: TOMETICH, DANIELLE  (contact)

PROGRAM_OFFICER_NAME: HOROWITZ, TODD S

PROJECT_TERMS: acceptability and feasibility;actigraphy;Acute;Address;Adherence;Adolescence;Adolescent;Adolescent and Young Adult;Adolescent and young adult cancer patients;Adult;Advisory Committees;Affect;Age;Attention;Behavior assessment;Behavior Therapy;Behavioral;Brain region;Breast Cancer survivor;Cancer Center;Cancer Control;cancer diagnosis;Cancer Survivor;cancer therapy;cancer-related cognitive impairment;career development;Case/Control Studies;Cognition;Cognitive;Cognitive deficits;cognitive function;cognitive performance;cognitive testing;Communities;comparison control;Comprehensive Cancer Center;Controlled Environment;critical period;Cross-Sectional Studies;Data;Data Analyses;Dementia;Depressed mood;design;Development;Development Plans;Diagnosis;Ecological momentary assessment;Education;Evaluation;Executive Dysfunction;experience;Exposure to;Fatigue;Future;Gender;Goals;high school;Impaired cognition;improved;Informal Social Control;innovation;Intervention;Interview;Knowledge;Life;Literature;Long-Term Survivors;Low Prevalence;Malignant Neoplasms;Measures;Memory;Mentorship;Methodology;Methods;middle age;modifiable risk;neurodevelopment;Neuropsychological Tests;Neuropsychology;neurotoxic;neurotoxicity;Occupational;Occupations;Participant;Patient Self-Report;Personal Satisfaction;Phase;Physical activity;physical symptom;Population;Populations at Risk;Positioning Attribute;Predisposition;Prevalence;Problem Solving;Procedures;programs;Prospective Studies;psychological symptom;Puberty;Qualifying;Quality of life;Recording of previous events;recruit;Reporting;Research;Research Personnel;Risk Factors;Sampling;Schools;Short-Term Memory;skill acquisition;Sleep;Sleep disturbances;Stress;Surveys;Survivors;survivorship;Time;Training;Traumatic Brain Injury;United States;Vulnerable Populations;Work;Wrist;young adult

PROJECT_TITLE: Cancer-related cognitive impairment: Real-time evaluation and assessment of long-term impact of treatment on young adult survivors (CRCI REALITY)


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Lung;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Assessment of active pulmonary fibrosis, a progressive, fatal disease characterized by unrelenting scarring and stiffening of the lungs, is critical for appropriate therapeutic treatment. This project is relevant to public health as it aims to determine the capacity of a novel positron emission tomography (PET) probe to accurately detect pulmonary fibrosis disease activity in mice and chemically optimize it to enable future clinical translation. These studies will serve as a foundation for future clinical applications of this PET-based probe as a non-invasive method for assessment of activity for this deadly disease, in order to determine best treatment for patients, reduce their illness, and lengthen their lives.

PI_NAMEs: BERNAU, KSENIJA  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Address;Advisory Committees;Affinity;analog;animal imaging;Animal Model;antifibrotic treatment;Applied Skills;Award;Bacterial Adhesins;Binding;Biology;Bleomycin;career;Cessation of life;Characteristics;Chemicals;Chemistry;Cicatrix;Clinical;clinical application;Clinical Research;clinical translation;Collagen;Decision Making;Dedications;Deposition;Detection;Development;Diagnosis;Disease;Disease Management;Disease Progression;Dose;Drug Kinetics;Edema;Effectiveness;Elements;Extracellular Matrix;Extracellular Matrix Proteins;FDA approved;Fibrillar Collagen;Fibronectins;Fibrosis;fibrotic lung;Foundations;Future;Glycoproteins;Goals;Half-Life;High Resolution Computed Tomography;Human;human disease;idiopathic pulmonary fibrosis;Image;imaging biomarker;imaging modality;imaging probe;immunogenicity;improved;In Vitro;in vivo;Inflammatory;Injections;Injury;innovation;Intervention;Investigational New Drug Application;Lung;lung injury;Medicine;Mentorship;Methods;Modality;Modeling;molecular imaging;Molecular Probes;Monitor;Morbidity - disease rate;mortality;Mus;nanomolar;neoplastic cell;New Drug Approvals;Noise;non-invasive monitor;novel;optimal treatments;Organ;Outcome;Pathologic;Patient Care;Patients;Peptides;Performance;Persons;Pharmacology;Phase;Polyethylene Glycols;Positron-Emission Tomography;pre-clinical;preclinical development;preservation;Process;Public Health;Pulmonary Fibrosis;Pulmonary function tests;Radiation exposure;Radiolabeled;radiotracer;Research;Research Infrastructure;Resources;Respiratory Failure;response;Role;scaffold;serial imaging;Signal Transduction;Source;Streptococcus pyogenes;Testing;Therapeutic;Time;tool;Training;training opportunity;treatment response;Universities;uptake;Wisconsin;Work;wound healing

PROJECT_TITLE: Optimization and development of extracellular matrix-targeting probes for PET-based assessment of lung fibrosis disease activity


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

PHR: Project Narrative Cancer metastasis is a deadly, elusive, and heterogeneous disease which lacks effective targeted therapeutics, and understanding the mechanisms underlying cancer metastasis remains to be fully elucidated. RNA splicing lends to cellular complexity and heterogeneity by producing distinct RNA and protein isoforms from a single gene, and the dysregulation of RNA splicing has been implicated in cancer development and progression. This research proposal seeks to identify novel mechanisms in which dysregulated alternative splicing contributes to metastatic seeding and outgrowth in breast and other aggressive cancers, with the ultimate goal of identifying potential biomarkers and therapeutic targets of cancer metastasis.

PI_NAMEs: PARKER, KIMBERLY  (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Address;Affect;Alternative Splicing;angiogenesis;Automobile Driving;Binding;Bioinformatics;Biology;Breast;Breast Cancer Cell;breast cancer metastasis;cancer cell;Cancer Etiology;cancer stem cell;career;Cell Survival;Cells;Cessation of life;Clinical;Clinical Research;Coiled-Coil Domain;Complex;crosslinking and immunoprecipitation sequencing;Data;Development;Disease;Disseminated Malignant Neoplasm;Distal;Epigenetic Process;Event;Fibroblasts;Foundations;Future;Genes;Genetic;Goals;Grant;Heterogeneity;Immune Evasion;Immunologic Surveillance;improved;In Vitro;in vivo;Individual;Integrins;International;Invaded;Investigation;Learning;Ligase;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;meetings;Mentors;Mentorship;Metastatic breast cancer;Methods;Molecular;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;Organ;overexpression;Paper;Patient-Focused Outcomes;Phase;Phenotype;Play;Population;post-doctoral training;Postdoctoral Fellow;potential biomarker;pre-doctoral;preclinical study;Primary Neoplasm;Process;programs;Proliferating;Protein Isoforms;Proteins;Regulation;Relapse;Research;Research Activity;Research Institute;Research Project Grants;Research Proposals;response;RNA;RNA Processing;RNA Splicing;RNA-targeting therapy;Role;Scientist;self-renewal;Signal Transduction;Site;skills;stem cell biomarkers;student mentoring;symposium;T-Lymphocyte;targeted treatment;Techniques;Therapeutic;therapeutic target;Tissues;tool;Transcript;transcriptome sequencing;transcriptomics;triple-negative invasive breast carcinoma;tumor growth;tumor initiation;tumor microenvironment;tumorigenic;United States;Untranslated RNA;Validation;Variant;Work;Writing

PROJECT_TITLE: Elucidating the role of RNA splicing in the metastatic seeding and outgrowth of aggressive cancers.


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunization;Immunotherapy;Precision Medicine;Radiation Oncology;Vaccine Related

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Metastasis is responsible for about 2/3 of cancer deaths. This proposal aims to improve the treatment outcome of metastatic cancer by enhancing the antitumor effect of radiation therapy through combination with agents that stimulate the host’s innate immunity. Completion of this project will open new possibilities of cancer immunotherapy to treat metastatic cancers.

PI_NAMEs: FANG, YAN  (contact)

PROJECT_TERMS: Abscopal effect;Advanced Malignant Neoplasm;anti-cancer;anti-tumor immune response;Antibodies;Antigen-Presenting Cells;antitumor effect;Autophagocytosis;Back;cancer immunotherapy;cancer prevention;cancer therapy;Cancer Vaccine Related Development;Cancer Vaccines;Cell Death;cell killing;Cells;Cessation of life;Computational Technique;Cross Presentation;Cytotoxic T-Lymphocytes;Data;Data Analyses;Defect;design;Disseminated Malignant Neoplasm;Distal;experimental study;Generations;genomic data;Goals;Growth;high dimensionality;Immune;immune function;Immune response;Immune system;Immunity;Immunologic Surveillance;Immunotherapy;improved;in vivo;Injections;innate immune sensing;innovation;Interferons;Irradiated tumor;ITGAM gene;Knowledge;Macrophage;Malignant Neoplasms;Mediating;Modeling;mouse model;Mus;Mutant Strains Mice;Natural Immunity;neoantigens;Neoplasm Metastasis;neoplastic cell;neutrophil;novel;novel therapeutic intervention;Outcome;Pathway interactions;Patients;Phase;Population;Radiation;Radiation therapy;Research;Research Personnel;Resources;response;Role;Signal Pathway;single-cell RNA sequencing;skills;Stimulator of Interferon Genes;targeted treatment;Technology;Testing;Therapeutic;transcriptome;Transplantation;treatment effect;Treatment outcome;treatment strategy;tumor;Tumor Antigens;tumor DNA;tumor growth;tumor heterogeneity;Tumor Immunity;tumor immunology;tumor microenvironment;Tumor-infiltrating immune cells;Work

PROJECT_TITLE: Enhancing the antitumor effect of radiation therapy by targeting the cGAS-STING pathway


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: Project Narrative This proposed K01 application seeks to compare different dietary patterns and determine which ones may be better suited for diabetes prevention among high-risk acute pancreatitis (AP) patients in the NIH-funded Diabetes RElated to Acute Pancreatitis and its Mechanisms (DREAM) study. This study will provide a novel understanding of the critical role of different dietary patterns in preventing new-onset diabetes following AP. It also opens new potential avenues for research into the pathophysiological mechanisms by which dietary patterns affect this risk, as currently being investigated in the DREAM study.

PI_NAMEs: BA, DJIBRIL M (contact)

PROGRAM_OFFICER_NAME: GOROSPE, RAFAEL

PROJECT_TERMS: Accounting;Acute;acute pancreatitis;Affect;Alcohol consumption;American;Antioxidants;Beta Cell;Biological Markers;Biometry;Blood Glucose;Body Weight Changes;career development;Cell Physiology;cigarette smoking;Clinical;clinical research site;college;comorbidity;Complication;Consumption;Data;Data Coordinating Center;Development;diabetes management;Diabetes Mellitus;Diabetes prevention;diabetes risk;Diet;dietary;Dietary Component;Dietary Fiber;Dietary Practices;Disease;Doctor of Philosophy;Endocrinologist;endothelial dysfunction;epidemiologic data;Epidemiologist;epidemiology study;Exocrine pancreas;Failure;Fasting;Fishes;follow-up;Food;Foundations;Frequencies;Fruit;fruits and vegetables;Functional disorder;Funding;Future;Gastroenterologist;General Population;Glycosylated hemoglobin A;Goals;Health Sciences;Healthy Eating;high risk;Hospitalization;Hyperglycemia;Hyperinsulinism;indexing;Inflammation;Inflammatory;Insulin;Insulin Resistance;insulin secretion;Insulin-Dependent Diabetes Mellitus;Intake;Intervention;Knowledge;Knowledge acquisition;knowledge base;Lead;Leadership;Learning;longitudinal analysis;Meat;Mediation;Mediator;Medicine;Mediterranean Diet;Mentored Research Scientist Development Award;Mentors;Metabolic;Modeling;modifiable risk;novel;Nutritional;nutritional epidemiology;Olive oil preparation;Oxidative Stress;Pancreatitis;Participant;Pathway interactions;patient population;Patients;Plants;Prediabetes syndrome;prevent;Prevention;primary outcome;Processed Meats;professor;prospective;Prospective, cohort study;Public Health;Qi;Qualifying;Questionnaires;Raja;Recommendation;red meat consumption;Research;Research Personnel;Research Project Grants;Risk;Risk Factors;Risk Reduction;Role;secondary outcome;Secondary to;skills;Structure of beta Cell of islet;systemic inflammatory response;Testing;Time;Tissues;Training;United States;United States National Institutes of Health;Vegetables;waist circumference;Weight;Work

PROJECT_TITLE: Dietary Predictors of New-Onset Diabetes following Acute Pancreatitis in the DREAM Study.

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Although there is a high prevalence of substance use disorders (SUDs), including opioid use disorder (OUD), among people incarcerated in the US, only a small portion receive evidence-based treatment for SUDs, as well as screening and medication for OUD. This proposed K23 application involves career development training and a complementary research project incorporating implementation science methods to gain a comprehensive understanding of how an evidence-based digital therapeutic for substance use—Computer Based Training for Cognitive Behavioral Therapy (CBT4CBT)—could be effectively implemented as a treatment for incarcerated people with current OUD (primary), as well as other SUD(s).

PI_NAMEs: LOYA, JENNIFER M (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: Abstinence;acceptability and feasibility;addiction;Address;Adherence;Affect;Aftercare;Area;arm;Attitude;Behavioral;burnout;career;career development;Career Mobility;Certification;Clinical Practice Guideline;Clinical Trials;Cognitive;Cognitive Therapy;Connecticut;Correctional Institutions;cost;Counseling;craving;Data;Data Analyses;digital treatment;E-learning;Educational workshop;evidence base;Evidence based treatment;experience;Future;Goals;Health Personnel;Health Services Accessibility;High Prevalence;implementation barriers;implementation facilitators;implementation framework;implementation science;implementation strategy;Imprisonment;improved;Impulsivity;Individual;Intervention;Intervention Studies;Interview;Jail;Knowledge;Learning;Licensing;Measures;medication for opioid use disorder;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;Methods;Monitor;opioid use;opioid use disorder;Outcome;Participant;patient oriented;patient oriented research;Perception;Persons;phenomenological models;Population;Positioning Attribute;Professional counselor;programs;Provider;Qualitative Methods;Qualitative Research;Quality of Care;Randomized, Controlled Trials;Readiness;Recommendation;relapse risk;Reporting;Research;Research Activity;Research Methodology;Research Personnel;Research Project Grants;Research Proposals;screening;Self Efficacy;Services;skills;Staff Attitudes;Structure;substance use;Substance Use Disorder;substance use treatment;symposium;Tablets;Theoretical Domains framework;Training

PROJECT_TITLE: Implementing a Digital Therapeutic to Address Substance Use Disorders among People who Are Incarcerated

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-W (02)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences;Pediatric

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE This K99/R00 Pathway to Independence Award seeks to provide training in parent-infant ECG/EEG, qualitative interviews of subjective experiences, multi-modal data integration (qualitative-quantitative, neuro-bio-behavior, longitudinal), advanced biostatistics, psychology and neuroscience to support the applicant’s transition to research independence. Through the training plan, the applicant will develop the skills and expertise necessary to establish a trans-disciplinary translational research program that integrates multiple novel subjective and biobehavioral measures into the study of human dyadic interactions, to uncover mechanisms of parent-child dyadic relational health – with a primary focus on emotional synchrony – that yield long-term health and wellbeing through optimized socioemotional functioning. This approach may lead to the development of precision interventions that improve socioemotional functioning based on deeply characterized emotional and biobehavioral processes.

PI_NAMEs: LAVALLEE, ANDREANE  (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Academy;Affect;African American;American;Area;Award;Behavior;Behavioral;biobehavior;Biometry;Birth;Black race;blind;bodily sensation;body map;Brain;career;career development;Chest;Child;Childhood;Clinical Research;Code;cohort;Cues;Data;Data Correlations;data integration;Development;Development Plans;dyadic interaction;Effectiveness;Electrocardiogram;Electroencephalography;Emotional;emotional experience;emotional functioning;Emotions;Evaluation;experience;Experimental Designs;Eye;Fathers;Feeling;Foundations;Frequencies;gaze;Goals;Health;Heart;heart rhythm;Hispanic;Human;improved;Individual;Infant;Intervention;Intervention Studies;Interview;Knowledge acquisition;Lead;lens;Life;Life Cycle Stages;Link;Literature;Love;Maps;Maternal Age;Measures;Mothers;multimodal data;neural;Neurosciences;novel;Outcome;Paper;Parents;Pathway interactions;Pediatrics;Personal Satisfaction;personalized intervention;Physiological;Policies;positive emotional state;Process;programs;Psychology;Qualitative Methods;Research;Research Support;respiratory;response;Sampling;Series;showing emotion;Signal Transduction;Sinus Arrhythmia;skills;social cognition;social culture;Structure;Surveys;Technical Expertise;Thalamencephalon;therapy development;Time;Training;Training Support;translational research program;verbal;wireless;Work

PROJECT_TITLE: Emotional and biobehavioral mechanisms of parent-infant emotional synchrony

STUDY_SECTION_NAME: Biobehavioral and Behavioral Sciences Study Section[CHHD-H]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome

PHR: Project Narrative  Current targeted therapies for metastatic CRC patients show limited positive outcome, especially in KRAS*-driven metastatic CRC patients where KRAS* bypasses targeted therapies to activate downstream survival, proliferation and cell cycle progression signaling. Understanding the molecular and cellular biological mechanisms of CRC progression will ultimately lead to new targets to prevent or treat advanced disease and prolong survival of metastatic CRC patients. This proposal seeks to investigate 1) the interplay between KRAS*- driven cancer cells and carcinoma-associated stroma, and 2) the impact of telomere dynamics and associated genomic events that promote metastatic CRC, in order to precisely design new targeted therapies and further advance public health.

PI_NAMEs: HSU, WEN-HAO  (contact)

PROJECT_TERMS: Address;Adipocytes;advanced disease;Alleles;angiogenesis;Automobile Driving;Biological;Biological Assay;Bypass;cancer cell;Cancer Model;Carcinoma;Catalogs;Cell Culture Techniques;Cell Cycle Progression;Cell Line;cell type;Cells;Chromosomal Instability;Clinic;Coculture Techniques;colon cancer patients;Colorectal Cancer;colorectal cancer metastasis;colorectal cancer progression;conditional knockout;CXCL3 gene;cytokine;Cytokine Gene;Data;Data Set;design;Development;Diagnosis;Disease;Disease Progression;DNA Sequence Alteration;Drops;Embryo;Engineering;Event;Fibroblasts;Functional disorder;Gene Expression;Gene set enrichment analysis;Genes;Genetic;genomic aberrations;Genomic Instability;Genomics;Goals;Histologic;Human;Human Engineering;Immune;Impairment;in silico;in vivo;KRAS oncogenesis;KRAS2 gene;KRASG12D;lipid biosynthesis;Lipids;lymph nodes;Maintenance;Malignant - descriptor;Malignant Neoplasms;Mediating;metastatic colorectal;Metastatic Neoplasm to the Bone;metastatic process;Minority;Modeling;Molecular;mouse model;Mus;Mutation;Myelogenous;Myeloid-derived suppressor cells;Nature;Neoplasm Metastasis;new therapeutic target;novel;Oncogenes;Oncogenic;Outcome;Pathway interactions;Patients;Phase;Phenotype;Postdoctoral Fellow;prevent;Proliferating;promoter;prostate cancer model;Public Health;recruit;Recurrence;Reporter;Research;Research Project Grants;RNA-Directed DNA Polymerase;Role;Signal Transduction;single-cell RNA sequencing;Stromal Cells;Surveys;Survival Rate;targeted treatment;Telomerase;telomere;The Cancer Genome Atlas;therapeutic target;TP53 gene;Training;trait;transcription factor;Transforming Growth Factor beta;Transgenes;tumor;Tumor Biology;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;tumorigenesis;Work

PROJECT_TITLE: Oncogenic Kras drives stromal adipogenesis to promote colorectal cancer (CRC) progression


NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: PROJECT NARRATIVE Cancer continues to be a leading cause of death worldwide and the poor efficacy and toxicity of the available treatments are exemplified by the low survival rates and the severity of the side effects. The long-term goal of both the F99 and K00 phases of this work will be to reveal new strategies that lead to novel anti-cancer therapies. The F99 phase will be focused on a cell-intrinsic aspect of cancer biology, while the K00 phase will focus on an immune cell with great potential to directly inhibit tumor growth and to modulate the efficacy of already approved cancer immunotherapies.

PI_NAMEs: SAKUMA, STEPHEN  (contact)

PROJECT_TERMS: 3-Dimensional;addiction;Biological Assay;Cancer Biology;cancer cell;cancer immunotherapy;cancer therapy;Cause of Death;Cell Death;Cell Nucleus;Cell Physiology;Cell Proliferation;cell type;Cells;clinical efficacy;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Complex;effective therapy;Environment;Eukaryota;experimental study;Flow Cytometry;Genes;Genetic;Genetic Transcription;Goals;Imaging Techniques;Immune;immune checkpoint blockade;immune checkpoint blockers;Immunooncology;Immunosuppression;Individual;knock-down;knockout gene;Leukocytes;Macrophage;Malignant Neoplasms;Measurement;Measures;Mediating;member;Messenger RNA;Metabolism;Methods;Molecular;monocyte;mRNA Transcript Degradation;neoplastic cell;novel;Nuclear Pore Complex;Nuclear Pore Complex Proteins;nucleocytoplasmic transport;Pathway Analysis;Pathway interactions;Patients;Phase;Phenotype;Postdoctoral Fellow;programs;Proliferating;protein structure;Proteins;Regulation;Regulator Genes;Research;Research Project Grants;response;Role;Severities;side effect;single-cell RNA sequencing;Small Interfering RNA;spheroids;Stains;stem;Structure;success;Surface;Survival Rate;T-Lymphocyte;Therapeutic;Toxic effect;Translational Repression;tumor;tumor growth;tumor microenvironment;tumor xenograft;Tumor-associated macrophages;tumor-immune system interactions;tumorigenic;whole genome;Work

PROJECT_TITLE: The role of the CCR4-NOT complex in the regulation of Nuclear Pore Complex assembly


ORG_NAME: NEW YORK GENOME CENTER

PHR: PROJECT NARRATIVE Single nucleotide polymorphisms (SNPs) in key immune regulatory molecules are associated with autoimmunity; accordingly, targeting of these molecules pharmacologically have resulted in revolutionized cancer treatment in the shape of immune checkpoint immunotherapies. Thus, through the F99 phase I will characterize how loss of the autoimmune-related molecule PTPN22 in myeloid cells drives an augmented immune response against tumors. Subsequently, through the K00 phase I will identify novel autoimmune related SNPs correlating with tumor immune infiltration and characterize them in engineered conditional knockout mice to understand their contribution to tumor progression and immunotherapy efficacy.

PI_NAMEs: ACERO BEDOYA, SANTIAGO  (contact)

PROJECT_TERMS: Antigens;Autoimmune;Autoimmune Diseases;Autoimmunity;Biological;Cancer Model;cancer therapy;Candidate Disease Gene;Cause of Death;CD8-Positive T-Lymphocytes;Cell Lineage;cell type;Cells;checkpoint therapy;Clinical;clinical efficacy;conditional knockout;Data;Databases;Dendritic Cells;Detection;Engineering;experimental study;Faculty;Funding;Genes;Genetic Polymorphism;genetic signature;genetic variant;Germ Lines;Goals;Heterogeneity;HLA Antigens;Human;Hyperactivity;Immune;immune activation;immune cell infiltrate;immune checkpoint;Immune response;Immune system;Immunotherapeutic agent;Immunotherapy;improved;Incidence;Individual;Infiltration;insight;Institution;Integration Host Factors;Investigation;Knockout Mice;knowledge base;Learning;Ligands;Link;loss of function;Macrophage;Malignant Neoplasms;member;mouse model;Mus;Mutation;Myeloid Cells;neoplasm immunotherapy;new therapeutic target;novel;patient subsets;Patients;pharmacologic;Phase;Postdoctoral Fellow;Process;programmed cell death ligand 1;programmed cell death protein 1;Protein phosphatase;PTPN22 gene;recruit;Recurrent disease;Refractory;Regulator Genes;Reporting;Research;Research Project Grants;Resistance;resistance mechanism;response;Risk;Role;Shapes;Signal Transduction;Single Nucleotide Polymorphism;Site;skills;Source;T cell response;T-Cell Activation;T-Lymphocyte;tenure track;Testing;tumor;Tumor Immunity;tumor immunology;tumor microenvironment;tumor progression;Tumor Suppressor Proteins;Tumor-infiltrating immune cells;United States;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Myeloid cell-expressed PTPN22 and anti-tumor immunity


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Serious Mental Illness

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Narrative: Rare, recurrent genetic variants occur with enough frequency in the population and confers significant risk for neuropsychiatric disorders but these genetic variant’s don’t lead to the same disorders or the severity of the disorders in the people that have them. We need a better way to predict what the effect of these recurrent genetic changes will be on a particular individual. We will study one such change, the 15q13.3 deletion syndrome by looking at the lifetime health records of 200 individuals with this deletion, recruit 75 individuals for deeper characterization using well-validated tools, combine these data into a big dataset to train a predictive algorithm to correctly identify individuals with this deletion syndrome, and predict risk for psychiatric and other disorder presentation in these individuals.

PI_NAMEs: SODA, TAKAHIRO  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Age;Age of Onset;algorithm training;Artificial Intelligence;autism spectrum disorder;Big Data;BIK gene;biomedical informatics;Bipolar Disorder;Characteristics;Clinical;clinically relevant;cohort;Complex;Copy Number Polymorphism;Data;data repository;Data Set;data standards;developmental disease;Diagnosis;Dimensions;Disease;early onset;Electronic Health Record;Epilepsy;experience;Frequencies;Funding;General Population;Generations;Genetic;genetic testing;genetic variant;Genome;Genomics;Grant;Health;health record;Home;Incidence;Individual;Investigation;K-Series Research Career Programs;Lead;Learning;Learning Skill;Link;Machine Learning;Major Depressive Disorder;Medical;Medical Genetics;Medicine;Mental disorders;Mental Health;Mentors;Methods;Modeling;Molecular;Mutation;neurobehavioral;Neurodegenerative Disorders;Neurologic;neuropsychiatric disorder;neuropsychiatry;Participant;Penetrance;Persons;phenome;Phenotype;phenotypic data;Physicians;polygenic risk score;Population;population based;portability;prediction algorithm;prognostication;Protocols documentation;Publications;recruit;Recurrence;Research;Resources;Risk;risk prediction;Schizophrenia;Scientist;screening;Semantics;Sensitivity and Specificity;Series;Severities;Site;skills;soft drink;Standardization;Symptoms;Syndrome;Techniques;Testing;tool;Training;training data;trait;Validation;Variant;Work

PROJECT_TITLE: Elucidating the full phenotype of the 15q13.3 deletion syndrome

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: CAMBRIDGE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: HARVARD UNIVERSITY

PHR: PROJECT NARRATIVE The proposal aims to develop methods to understand how mechanical forces influence the functions of T cells, which rid our bodies of cancer cells. If successful, this project will lead to improved methods of engineering the immune system to fight cancer.

PI_NAMEs: HU, YUESONG  (contact)

PROJECT_TERMS: adaptive immune response;Address;Adjuvant;Adoptive Cell Transfers;antigen binding;antigen detection;Antigen-Presenting Cells;Antigens;Area;Autoantigens;Biological Assay;cancer cell;cancer immunotherapy;cancer therapy;CD28 gene;CD80 gene;Cell Adhesion Molecules;Cell membrane;Cell Physiology;Cell Size;Cell surface;Cell Surface Receptors;Cell Survival;Cells;chemical property;Chemicals;Communication;Complex;cytokine;cytotoxic;Cytotoxic T-Lymphocytes;cytotoxicity;design;Discrimination;DNA;Doctor of Philosophy;Dose;Drug Delivery Systems;Drug Modulation;effective therapy;Engineering;Environment;Event;exhaustion;fighting;Flow Cytometry;Fluorescence;Goals;Granzyme;Immune;immune modulating agents;immune reconstitution;Immune response;immunoengineering;immunological synapse;immunological synapse formation;Immunology;improved;Induction of Apoptosis;Infusion procedures;Integrins;Intercellular adhesion molecule 1;Intercellular Junctions;Investigation;laser tweezer;Ligands;Link;Lymphocyte Function;Malignant Neoplasms;Measurement;Measures;mechanical force;mechanical signal;Mechanics;mechanotransduction;Mediating;Methods;migration;Minor;Molecular;molecular mechanics;mutant;nanodevice;Nature;optic tweezer;particle;Particle Size;Patients;Pattern;Peptide Fragments;Peptide Hydrolases;Peptides;perforin;permissiveness;Pharmaceutical Preparations;Phase;physical property;Plasma Cells;PLAUR gene;post-doctoral training;Postdoctoral Fellow;Proliferating;Proteins;receptor;receptor binding;Research;Research Project Grants;response;Role;Scanning;Science;Sea;Seminal;sensor;side effect;Signal Transduction;single molecule;skills;spatiotemporal;Specificity;Spectrum Analysis;Speed;Surface;Synapses;T cell response;T cell therapy;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Techniques;Testing;Time;Tissues;tool;tool development;Touch sensation;Traction;Transfusion;transmission process;tumor;Tumor Antigens;tumor eradication;unpublished works;Work

PROJECT_TITLE: Mechanically active artificial antigen presenting cells for cancer immunotherapy


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE  Black, Indigenous, People of Color (BIPOC) and Lesbian, Gay, Bisexual, Transgender, and Queer (LGBTQ+) communities experience disparities in the quality of mental health care. There are no feasible, scalable tools to date that provide feedback surrounding culturally responsive care. The purpose of the current study is to develop a natural language processing-based feedback tool to improve culturally responsive care among therapists.

PI_NAMEs: KUO, PATTY BEYRONG (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: acceptability and feasibility;Address;Behavioral;Black, Indigenous, People of Color;Caring;Client;Clinic;Clinical;Clinical Trials;Code;Communities;community advisory board;community based research;community partners;community partnership;Competence;cultural competence;Data Set;Development;Discrimination;Disparity;Effectiveness;Empathy;Evaluation;experience;Feedback;Funding;Future;Gender;health care disparity;healthcare community;Healthcare Systems;Human;improved;improved outcome;Individual;Inequity;innovation;Institution;interest;Intervention;Interview;Label;Lead;Lesbian Gay Bisexual Transgender Queer;Machine Learning;Measures;meetings;member;Mental Health;Mental Health Services;Methods;Modeling;motivational enhancement therapy;multidisciplinary;National Institute of Mental Health;Natural Language Processing;novel;Outcome;outcome prediction;Patients;Perception;Performance;Philadelphia;Population;Positioning Attribute;Process Measure;prototype;Provider;psychological distress;Psychotherapy;Race;randomized, clinical trials;Research;Research Personnel;Resources;scale up;Service delivery model;Sexuality;skills;software systems;Speech Recognition Software;Speed;Standardization;Strategic Planning;support tools;Technology;Testing;Text;Therapeutic;tool;Training;Transcript;treatment disparity;Treatment outcome;usability;user centered design;Work

PROJECT_TITLE: Development of a natural language processing (NLP) based therapist tool for culturally responsive care

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-I (01)]


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: NEW YORK

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: PROJECT NARRATIVE Dysfunctional lipid accumulation is characteristic of numerous metabolic diseases and pathologies including insulin resistance, heart failure, and hepatic steatosis. Enhanced understanding of the molecular mechanisms controlling all aspects of lipid metabolism, such as phospholipid metabolism, holds great promise for the treatment of these diseases. This proposal seeks to understand the importance of FLVCR1 mediated phospholipid metabolism in organismal physiology and test the therapeutic potential of targeting FLVCR1 in disease.

PI_NAMEs: KENNY, TIMOTHY COLE (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Acetylcholine;Adult;Affect;Affinity;Anabolism;Betaine;Biochemical;Biochemical Reaction;Biochemistry;biological adaptation to stress;body position;Cell membrane;Cell Physiology;Cell Survival;Cells;Cellular Membrane;Cellular Stress;Characteristics;Choline;choline transporter;conditional knockout;Cryoelectron Microscopy;Data;Defect;Development;Diet;Disease;DNA Methylation;efficacy evaluation;Embryo;Environment;Epigenetic Process;Ethanolamines;Fatty Liver;Feedback;Feline Leukemia Virus;Genetic;Genetic Screening;Genetic Transcription;genome wide association study;Growth;Hand;Head;Health;Heart failure;Homeostasis;Human;human disease;Human Genome;in vivo;in vivo evaluation;innovation;Insulin Resistance;Knockout Mice;Laboratories;Lecithin;lipid metabolism;Lipids;Mammalian Cell;Mammals;Mediating;Membrane;Membrane Lipids;Membrane Proteins;Membrane Transport Proteins;Metabolic;Metabolic Diseases;Metabolism;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Mitochondrial Proteins;Molecular;mouse model;Mus;Mutation;nonalcoholic steatohepatitis;Null Lymphocytes;Nutrient;Pathology;Pathway interactions;Phosphatidylethanolamine;Phospholipid Metabolism;Phospholipids;Physiological;Physiology;professor;Proliferating;Protein Import;Proteins;Publishing;receptor;Regulation;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;Series;small molecule;stable isotope;Stress;Study of serum;Subgroup;synthetic lethal interaction;Tamoxifen;tenure track;Testing;therapeutic evaluation;Tissues;tomography;Training;Up-Regulation;uptake;Vitamins;Work

PROJECT_TITLE: Deciphering the role of phospholipid homeostasis in physiology and disease

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Diabetes;Women's Health Research

PHR: PROJECT NARRATIVE Patients with comorbidity of diabetes mellitus and breast cancer have been shown to be at a greater risk of poor prognosis and death than non-diabetic patients. However, the interplay between tumor progression and diabetes is still mechanistically unclear. Noting that glycation stiffens tumor ECM and ECM stiffening promotes tumor progression, here, I will investigate the mechanism by which diabetic hyperglycemia-mediated glycation promotes breast tumor progression via ECM stiffening to uncover potential adjuvant therapy for diabetic cancer patients.

PI_NAMEs: WANG, WENJUN  (contact)

PROJECT_TERMS: Address;Adjuvant Therapy;Advanced Glycosylation End Products;aminoguanidine;Behavior;Biological Assay;Blood Glucose;Blood Vessels;breast cancer progression;Cancer Patient;carcinogenicity;cell behavior;cell type;Cells;Cessation of life;Chronic;Collagen;comorbidity;Complex;crosslink;Data;Diabetes Mellitus;diabetic;Diabetic mouse;Disease;Endothelial Cells;Endothelium;Environment;Epidemiology;Epithelium;experience;Extracellular Matrix;Fellowship;Foundations;Future;glycation;Goals;Grant;Human;Hyperglycemia;Immune;immune cell infiltrate;Inflammation;Inflammatory;inhibitor;Link;Macrophage;malformation;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mechanics;Mediating;Mesenchymal;migration;Modeling;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;Patients;Pharmacologic Substance;Phase;Phenotype;Population;Positioning Attribute;Postdoctoral Fellow;Process;Prognosis;Proliferating;Reaction;receptor for advanced glycation endproducts;Research;Research Project Grants;Risk;Role;Signal Transduction;Specimen;Structure;sugar;Testing;Therapeutic Intervention;Training;tumor;Tumor Angiogenesis;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-associated macrophages;Tumor-infiltrating immune cells;tumorigenesis;type I and type II diabetes

PROJECT_TITLE: Diabetes Promotes Breast Tumor via Glycation-Induced Mechanical Changes in ECM


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Epilepsy;Genetics;Human Genome;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE  The study of neural-tumor cell interactions and how they contribute to glioma progression represents an emerging research paradigm in brain tumor biology. In my predoctoral studies, I will examine the contributions of synaptogenic genes towards disease progression via tumor-extrinsic synaptic dysregulation and hyperexcitability. In my postdoctoral studies, I will examine differences in tumor-intrinsic electrophysiological properties of glioma cells and investigate the functional contributions of those cells to the progression and evolution of malignant gliomas over time.

PI_NAMEs: CURRY, RACHEL NAOMI (contact)

PROJECT_TERMS: Acceleration;Accounting;Activity Cycles;Adult Glioma;Affect;Automobile Driving;Back;Bar Codes;Binding;Biochemical;Biological Assay;Brain;Brain Neoplasms;career;Cell Communication;Cell Cycle;Cell Proliferation;Cell secretion;Cells;Classification;Collecting Cell;Complex;Data;Dedications;Diagnosis;Disease;Disease Progression;early onset;Electrocorticogram;Electroencephalography;Electrophysiology (science);Electroporation;Epilepsy;Etiology;Event;Evolution;experimental study;Feeds;gain of function;Gene Expression;Genes;Glioblastoma;Glioma;glioma cell line;Goals;Human;Image;Immunoglobulins;in utero;In Vitro;in vivo;Incidence;Individual;innovation;interest;Investigation;Isocitrate Dehydrogenase;Label;Laboratories;loss of function;Maintenance;Malignant - descriptor;Malignant Glioma;Malignant neoplasm of brain;Malignant neoplasm of central nervous system;Malignant Neoplasms;Mediating;member;Methodology;migration;Modeling;Molecular;Molecular Profiling;mouse model;multidisciplinary;Mus;mutant;mutational status;neoplastic cell;neurodevelopment;Neuroepithelial, Perineurial, and Schwann Cell Neoplasm;neuronal circuitry;neuronal tumor;Neurons;Neurosciences;novel;novel therapeutic intervention;Operative Surgical Procedures;overexpression;Pathway interactions;Patients;Postdoctoral Fellow;postsynaptic;Potassium;Potassium Channel;pre-doctoral;precision medicine;Process;programs;Proliferating;Property;Proteins;Proteomics;Radiation therapy;Reporting;Research;Research Project Grants;Research Proposals;Role;Sampling;Scientific Inquiry;Secondary to;Seizures;Signal Pathway;single-cell RNA sequencing;Slice;standard of care;survival outcome;Survival Rate;Synapses;synaptogenesis;System;Techniques;technological innovation;Therapeutic;Time;transcriptome sequencing;transcriptomics;Transposase;Treatment Protocols;tumor;Tumor Biology;tumor progression;Tumor Promotion;Variant

PROJECT_TITLE: Decoding hyperexcitability in malignant glioma


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative Highly aggressive forms of breast cancer cells produce and release exosomes, a major class of extracellular vesicles (EVs), as a mechanism for intercellular communication that promotes cell growth, therapy resistance, as well as invasive activity and metastasis. I have recently discovered a novel mechanism by which the downregulation of the NAD-dependent deacetylase Sirtuin 1 (SIRT1) in aggressive breast cancer cells regulates RNA stability, leading to the increased production of exosomes enriched in proteins that strongly promote cancer cell invasion. I plan to further examine the broader consequences of this mechanism, as well as investigate the importance of EVs in mediating the interplay between aging and cancer progression, with the goal of identifying novel therapeutic targets and strategies for treating cancer.

PI_NAMEs: WANG, FANGYU  (contact)

PROJECT_TERMS: 3' Untranslated Regions;Acetylation;aged;aggressive breast cancer;Aging;Area;Binding;Biogenesis;Breast Cancer Cell;breast cancer progression;Cancer Biology;cancer cell;Cancer Cell Growth;Catalytic Domain;cell age;Cell Aging;cell growth;Cell membrane;Cell Physiology;Cell surface;Cell Survival;Cells;Cessation of life;Deacetylase;Development;Disease;Disease Progression;Down-Regulation;Ectopic Expression;Exonuclease;exosome;expectation;extend lifespan;Extracellular Space;extracellular vesicles;Goals;graduate school;graduate student;Grant;Hydrolase;Impairment;insight;intercellular communication;interest;Invaded;knock-down;Laboratories;Learning;Lysine;Lysosomes;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;migration;Multivesicular Body;Neoplasm Metastasis;new therapeutic target;novel;novel strategies;Pathway interactions;Patients;Persons;Phase;Play;Postdoctoral Fellow;prevent;pro-aging;Process;Production;protein expression;Proteins;recruit;Research;Research Personnel;Research Project Grants;Resistance;Risk Factors;RNA;RNA Stability;RNA-Binding Proteins;Role;senescence;senescent cell;SIRT1 gene;skills;small hairpin RNA;Therapeutic;Time;trafficking;trait;Transcript;transcriptome sequencing;tumor growth;tumor progression;Tumor Promotion;Tumor Suppressor Proteins;vacuolar H+-ATPase;Woman;Work

PROJECT_TITLE: SIRT1 Regulates RNA Stability to Promote Breast Cancer


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Climate-Related Exposures and Conditions;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: Narrative Many pathogens live in the environment prior to encountering a mammalian host. As a result, human interactions with the environment can alter the population of pathogens we are likely to encounter and thus with which we are infected. This proposal aims to understand how heat tolerance and drug resistance are controlled by genetic variation at two different time scales (across a genus and within a species) of opportunistic environmental fungal pathogens in order to better predict how pathogens are likely to be altered by human activities.

PI_NAMEs: BILLMYRE, ROBERT BLAKE (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Accidents;Address;Affect;Africa;Agriculture;Alleles;Animals;anti-fungal agents;Azole resistance;Azoles;Biological Assay;Body Temperature;Cessation of life;climate change;Clinical;Collection;Communities;Complex Genetic Trait;Cryptococcus;Cryptococcus neoformans;density;Development;Diploidy;Disease;Drug resistance;Environment;Evolution;experimental study;Exposure to;fitness;Fluconazole resistance;Fungal Drug Resistance;fungus;Future;Genes;Genetic;genetic approach;genetic architecture;Genetic Epistasis;Genetic Variation;Genome;genome-wide;global temperature;Global Warming;Goals;Growth;High temperature of physical object;HIV/AIDS;Human;Human Activities;Human body;human disease;human mortality;human pathogen;Immunocompromised Host;improved outcome;Individual;Infection;Intervention;Lead;Libraries;Mammals;Maps;Microbe;Modeling;Modernization;Mutagenesis;mutant;Mycoses;next generation sequencing;novel;pathogen;Pathogenesis;pathogenic fungus;Pathogenicity;Pharmaceutical Preparations;Phenotype;Plants;Population;Predisposition;pressure;Process;programs;Research;resistance mutation;Source;Techniques;Temperature;Testing;Time;tool;trait;transcriptional reprogramming;Treatment outcome;Variant;Virulence;Virulent;Work

PROJECT_TITLE: Evolution of heat tolerance and drug resistance in Cryptococcus

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 VSR-D (M1)]


ORG_DEPT: BIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The project aims at identifying and characterizing human T cell genes/molecules that contribute to suppressing effective antitumor T cell responses by utilizing culturable human T cells and cancer cell lines. In the short term, the study will help identify novel and potentially druggable immunological molecules and pathways for improving current cancer immunotherapy. In the long term, the study will lay the groundwork for systematically dissecting the human genetic and immunological basis of exceptionally beneficial antitumor immunity evoked in a minority of cancer patients by current checkpoint blockade immunotherapy, which will in turn continuously benefit patients with a broad spectrum of cancer.

PI_NAMEs: OGISHI, MASATO  (contact)

PROJECT_TERMS: Biochemical;Biological Assay;Biological Markers;Biology;cancer cell;Cancer cell line;cancer immunotherapy;Cancer Patient;cancer type;candidate validation;CD80 gene;Cell Line;Cells;Child;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Communicable Diseases;COVID-19 pneumonia;CRISPR screen;cytotoxicity;Development;Disease remission;Dissection;Etiology;Favorable Clinical Outcome;Functional disorder;Genes;Genetic;genetic approach;genome-wide;Germ-Line Mutation;Goals;Growth;Health;Human;Human Genetics;Immobilization;Immune;immune cell checkpoints;immune checkpoint;immune checkpoint blockade;Immunity;Immunologics;Immunooncology;immunoregulation;Immunosuppression;Immunotherapy;improved;In Vitro;Inherited;inter-individual variation;Interferon Type I;Intrinsic factor;Knock-out;Lesion;Ligands;Malignant Neoplasms;Mediating;Methods;Minor;Minority;Mismatch Repair;Mismatch Repair Deficiency;Modeling;Molecular;Mus;Mutation;neoantigens;Neoplasm Metastasis;neoplastic cell;next generation;novel;Outcome;Pathway interactions;patient subsets;Patients;pembrolizumab;Predictive Value;programmed cell death ligand 1;programmed cell death protein 1;receptor;Reporting;Reproducibility;Research;Research Personnel;response;RNA Interference;Role;Self Tolerance;severe COVID-19;Side;Signal Transduction;Somatic Mutation;Sorting;success;Surface;systemic autoimmunity;T cell response;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;transcriptome sequencing;tumor;Tumor Immunity;tumor immunology;Uncertainty;Work

PROJECT_TITLE: Genetic and immunological dissection of coinhibitory crosstalks between human T cells and cancer cells


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease;Neurosciences

PHR: Narrative Despite the importance of intestinal neuroimmunity, little is known about the role of cholinergic innervation in the pathogenesis of inflammatory bowel disease (IBD). In the proposed study, we will determine the mechanisms underlying the anti-inflammatory effect of enteric cholinergic signaling and will test the role of enteric cholinergic signaling using selective optogenetics in a model of chronic colitis that closely mirrors the pathophysiology of human IBD. To achieve these objectives, we will employ a variety of in vitro methodologies and in vivo models to elucidate the effects of cholinergic neuronal signaling on muscularis macrophages, inflammatory indices, transcriptomic changes, and smooth muscle contractility and motility.

PI_NAMEs: GOLDSTEIN, ALLAN M;RAHMAN, AHMED AYEDUR (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Ablation;Acute;Affect;alpha-bungarotoxin receptor;American;Anti-Inflammatory Agents;Antiinflammatory Effect;Attenuated;Bathing;Cells;Chemicals;Child;cholinergic;cholinergic neuron;Chronic;Clinical;Colitis;Colon;Communication;Crohn's disease;cytokine;Data;Development;dextran sulfate sodium induced colitis;Disease;Disease Progression;Disease remission;effective therapy;Electromyography;Enteral;Enteric Nervous System;Experimental Animal Model;Experimental Models;experimental study;Functional disorder;gastrointestinal function;Genetically Engineered Mouse;gut inflammation;Health Expenditures;Human;Immune;Immunity;immunoregulation;improved;In Vitro;in vivo Model;Incidence;indexing;Inflammation;Inflammatory;Inflammatory Bowel Diseases;innovation;insight;Intestinal Diseases;Intestines;Invaded;long-term sequelae;Macrophage;Measures;Mediating;Methodology;Modeling;Morbidity - disease rate;Morphology;Motility;motility disorder;Mus;Myenteric Plexus;nerve supply;Neuroglia;Neuroimmune;Neuroimmunomodulation;Neuronal Injury;Neurons;neurotransmission;Nicotinic Receptors;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Onset of illness;Operative Surgical Procedures;optogenetics;Organ;Participant;Pathogenesis;Pathology;Pathway interactions;Patients;Production;Quality of life;Relapse;Research;Role;Severities;Signal Transduction;Smooth Muscle;targeted treatment;Testing;Time;transcriptomics;treatment strategy;Ulcerative Colitis;Work

PROJECT_TITLE: Optogenetic activation of enteric cholinergic neurons to treat colitis

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]