NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: San Carlos

ORG_NAME: APERTURE THERAPEUTICS, INC.

PHR: PROJECT NARRATIVE  Neuroinflammation is a common pathologic mechanism in neurodegenerative diseases for which there are currently no effective cures, but a large number of single-nucleotide polymorphisms that are predicted to alter RNA expression and splicing in microglia, the CNS resident cells driving neuroinflammation, were found to be strongly associated with the risk of age-dependent neurodegeneration. The risk, onset, and progression of disease is often affected by the context of specific disease mutations and patient genetic background, but limited efforts were made to directly modulate function of the disease modifying genes in glia. Aperture Therapeutics, Inc. is developing a high-throughput target validation and drug discovery platform that embraces the genetic diversity to develop novel therapeutics for FTD and other neurodegenerative diseases with pathologic neuroinflammation.

PI_NAMEs: JACKO, MARTIN  (contact)

PROJECT_TERMS: Affect;Age;Age of Onset;age related neurodegeneration;age-related disease;ALS patients;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Amyotrophic Lateral Sclerosis;Antisense Oligonucleotides;Automobile Driving;Behavioral;Biological Assay;Brain;Catalogs;Cell Line;Cell Survival;Cells;Chemicals;Chemistry;Classification;Clinic;Clinical;Coculture Techniques;Dementia;Deposition;Development;Diagnosis;Disease;disease model;Disease Progression;DNA Sequence Alteration;Dose;Down-Regulation;drug candidate;drug discovery;drug efficacy;efficacy evaluation;extracellular;frontal lobe;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;functional genomics;Genes;Genetic;Genetic Models;Genetic Transcription;genetic variant;Genetic Variation;genomic data;Genomics;Goals;high throughput screening;Human;improved;In Vitro;in vivo;induced pluripotent stem cell;Inflammation;Inflammatory;inhibitor;Kinetics;Knock-out;Language;Late-Onset Disorder;Length;Link;Literature;Measurement;Measures;Microglia;Mission;Modeling;motor disorder;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;neuroinflammation;Neurons;neurotoxicity;new therapeutic target;novel;novel therapeutics;oligonucleotide therapeutics;Oligonucleotides;Onset of illness;Parkinson Disease;Pathologic;Pathology;patient derived induced pluripotent stem cells;patient stratification;Patients;Persons;Phagocytes;Phagocytosis;phase 2 study;Positioning Attribute;Proteins;Publishing;Risk;RNA Splicing;Rodent;Rodent Model;screening;Severities;Single Nucleotide Polymorphism;single-cell RNA sequencing;Specificity;Speech;success;Symptoms;targeted treatment;tau aggregation;TDP-43 aggregation;Temporal Lobe;Therapeutic;therapeutic candidate;Thinness;Tissues;Toxic effect;Transcript;transcriptome sequencing;Validation;Variant;Work

PROJECT_TITLE: Discovering targeted modulator of microglial activity as a candidate treatment for FTD and related dementias.


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;Lung;Pediatric;Sleep Research

ORG_CITY: LOUISVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: PGXL TECHNOLOGIES, LLC

ORG_STATE: KY

PHR: PROJECT NARRATIVE PGXL Technologies, LLC and ULRF are developing a rapid, simple-to-use, and cost-effective urine collection kit for detection of obstructive sleep apnea (OSA) in children, which will support diagnosis, patient monitoring, and screening. Approximately 3% of children have OSA and many are not diagnosed. Polysomnography (PSG) tests are reliable but limited by their high cost and requirement for an overnight sleep study at a clinic, making a simple non-invasive urine test beneficial and commercially attractive.

PI_NAMEs: BURNS, CHRISTOPHER THOMAS (contact)

PROGRAM_OFFICER_NAME: ALFINI, ALFONSO JOSEPH

PROJECT_TERMS: Address;Adenoidectomy;Adult;Advanced Development;Biological Assay;Biological Markers;Calibration;Child;Childhood;CLIA certified;Clinic;Clinical;Clinical Research;Collaborations;Collection;commercialization;Controlled Study;cost;cost effective;Data;design;Detection;Development;Diagnosis;diagnosis standard;Diagnostic;Diagnostic Equipment;Diagnostic Sensitivity;Diagnostic tests;efficacy evaluation;efficacy testing;Exposure to;Foundations;Funding;Gel;Goals;high throughput screening;Home;Hypertension;Hypoxia;Immunoassay;improved;in-vitro diagnostics;innovation;interest;Kininogenase;Laboratories;Legal patent;Licensing;Measurement;Methods;Monitor;Myocardial dysfunction;neurobehavioral;Neurocognitive Deficit;novel;novel strategies;Obstructive Sleep Apnea;Orosomucoid;Orthodontic;Patient Monitoring;Patients;Phase;Physical Examination;Physicians;point of care;Polysomnography;Population;Predictive Value;Process;protein biomarkers;Proteins;Publishing;rapid test;Reagent;Recording of previous events;Recovery;Recurrence;reduce symptoms;Reproducibility;Research;sample collection;Sampling;screening;Secure;Sensitivity and Specificity;sensor;Shipping;Silicon Dioxide;Sleep;Sleep disturbances;Small Business Technology Transfer Research;Snoring;Specificity;Specimen;standard of care;Stress;success;System;systemic inflammatory response;Technology;Testing;Time;Tonsillectomy;Treatment Efficacy;UMOD gene;Universities;Urine;urocortin;Work

PROJECT_TITLE: Novel Urine Collection Kit for Obstructive Sleep Apnea

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-B (11)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Breastfeeding, Lactation and Breast Milk;Cancer;Clinical Research;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Pediatric;Pediatric Cancer;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: POWAY

ORG_NAME: CBEZ, LLC

ORG_STATE: CA

PHR: The successful creation of affordable and universally-available bottle tops, breast pump parts, nipple shields, and pacifiers that are customized to a breastfeeding parent’s actual nipple and surrounding breast anatomy, as contemplated in US Patent No. 10,449,121 B2, has the potential to alleviate a myriad of breastfeeding challenges that lead to the early cessation of breastfeeding by promoting better fit of accessories, improving milk flow, decreasing maternal pain, reducing nipple damage, eliminating nipple confusion, prolonging breastfeeding, and supporting the transition/initiation to full breastfeeding for premature infants. Optimized breastfeeding is critical, because breastfed infants have reduced risk of sudden infant death syndrome (SIDS), severe lower respiratory disease, ear and gastrointestinal infections, leukemia, and diabetes, and breastfeeding mothers benefit from reduced risk of postpartum depression, cardiovascular disease, diabetes, and ovarian, breast, and endometrial cancer. Further, estimates suggest that one maternal or infant death could be prevented each year in the US for every 597 women who breastfeed optimally, that increased breastfeeding rates would save the US more than $3 billion annually, and that near universal breastfeeding could save 820,000 lives annually worldwide.

PI_NAMEs: KAIR, LAURA R (contact)

PROGRAM_OFFICER_NAME: FABIYI, CAMILLE

PROJECT_TERMS: 3-Dimensional;Academy;acceptability and feasibility;Address;Age;Age Months;American;Anatomic Models;Anatomy;Areola;Biomedical Engineering;Breast;Breast Feeding;breast pump;Breastfed infant;Businesses;Cardiovascular Diseases;cardiovascular disorder risk;Catalogs;Categories;Child;Clinical;Clinical Research;Clinical Trials;Communities;comparative;Conduct Clinical Trials;Confusion;cost;Custom;Data;Data Set;design;Development;Devices;Diabetes Mellitus;ear infection;efficacy evaluation;Endometrial Carcinoma;Engineering;Enteral Feeding;ethnic diversity;Exclusive Breastfeeding;experience;feeding;gastrointestinal infection;Gynecologist;Health;Hospitals;Human Milk;Image;imprint;improved;Individual;Infant;Infant Health;Infant Mortality;Interdisciplinary Study;interest;Internet;Interview;Knowledge;Laboratories;Lactation;Learning;Legal patent;Length of Stay;leukemia;Life;Life Cycle Stages;Machine Learning;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Mammary Gland Parenchyma;manufacture;Marketing;Maternal and Child Health;Maternal Mortality;Medical;Medicine;Mental Health;mHealth;Milk;Morphology;Mothers;multidisciplinary;Neonatal Intensive Care Units;Nipples;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Pacifiers;Pain;Parents;Participant;pediatrician;Pediatrics;Persons;Phase;Population;Positioning Attribute;postnatal;Postpartum Depression;Postpartum Period;premature;Premature Infant;prenatal;prevent;Price;Process;Production;prototype;Pump;Qualitative Research;racial diversity;Recommendation;recruit;Research;Research Personnel;Research Project Grants;Respiratory Disease;Risk;Scanning;Shapes;Small Business Technology Transfer Research;Specialist;Specific qualifier value;Stress;Structure;success;sucking;suckling;Sudden infant death syndrome;Surveys;Techniques;Time;Translating;Woman;Work;World Health Organization

PROJECT_TITLE: Custom Accessories for Breastfeeding Success

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-D (10)]


ORG_CITY: TEMPE

ORG_NAME: IMETABOLIC BIOPHARMA CORPORATION

ORG_STATE: AZ

PHR: Project Narrative Small dense low-density lipoprotein (sdLDL) is a widely recognized contributor to the pathogenesis of atherosclerosis and thus cardiovascular disease. Resistant to common cholesterol lowering medications, cardiovascular risk profiles can remain high in patients despite achieving target LDL cholesterol (LDL-c) reductions. A key component of sdLDL biology is the role of Apolipoprotein C-III (ApoC-III). We propose the development of novel candidate therapeutic molecules, dual-domain ApoC-III affinity binders that have apolipoprotein E mimetic function to facilitate sdLDL hepatic uptake. These candidate molecules have the potential to specifically address this residual medical unmet need of sdLDL pathology and additional value in addressing issues posed by triglyceride rich lipoproteins (TRL’s).

PI_NAMEs: KIERNAN, URBAN A (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Address;Affinity;Amino Acids;Animal Model;antagonist;apolipoprotein C-III;Apolipoprotein E;Apolipoproteins B;Atherosclerosis;Automobile Driving;Binding;Biological;Biology;Blood Vessels;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cause of Death;Cell Line;Cells;Chemistry;Cholesterol;Circulation;Clinical;Computer Models;design;Developing Countries;Development;Engineering;Evaluation;Evaluation Studies;Event;Exhibits;FDA approved;feasibility testing;Guidelines;Health;heparin proteoglycan;Hepatic;Hepatocyte;HepG2;high risk;Human;LDL Cholesterol Lipoproteins;Ligands;Link;Lipids;Lipolysis;Lipoproteins;Low Density Lipoprotein Receptor;Low-Density Lipoproteins;manufacture;Mediating;Medical;Metabolic;mimetics;Myocardial Infarction;novel;novel therapeutic intervention;particle;Pathogenesis;Pathology;patient population;Patients;Peptides;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Plasma;pre-clinical;Preclinical Testing;programs;Property;protein expression;Proteins;receptor;Research;Residual state;Resistance;Role;satisfaction;screening;Site;Small Business Innovation Research Grant;syndecan;System;Technology;Testing;Therapeutic;Therapeutic Agents;therapeutic candidate;Therapeutic Intervention;trait;Triglycerides;United States;uptake;Very low density lipoprotein;Work

PROJECT_TITLE: Therapeutic Approach to Clear sdLDL from Circulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-V (11)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Childhood Leukemia;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN DIEGO

ORG_NAME: AVANTGEN, INC.

PHR: Project Narrative Patients diagnosed with MDS or AML have limited treatment options, resulting in unfavorable clinical outcomes. In this study, we will embark on the essential stages of manufacturing and toxicology testing to advance our promising novel antibody candidate one step closer to assessing its potential clinical benefits for these patients.

PI_NAMEs: FAN, XIAOMIN  (contact)

PROGRAM_OFFICER_NAME: ZANE, LINDA KARINE

PROJECT_TERMS: Acute;Acute Myelocytic Leukemia;Affinity;AML/MDS;antagonist;Antibodies;Apoptotic;Biomanufacturing;Blast Cell;Blood Transfusion;Bone Marrow;Cell Line;Cells;Chemistry;chemotherapy;Chinese Hamster Ovary Cell;Clinical;Clinical Research;Clinical Trials;Clonal Expansion;Coculture Techniques;curative treatments;Data;Data Analyses;Development;Diagnosis;Disease;Dose;Drug Kinetics;Dysmyelopoietic Syndromes;efficacy study;Elderly;Ensure;Exhibits;Face;falls;FLT3 gene;Frail Elderly;Funding;Hematopoiesis;hematopoietic stem cell differentiation;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;High Dose Chemotherapy;Human;Immunoglobulin G;Immunoglobulin Idiotypes;Immunosuppressive Agents;improved;individual patient;Induction of Apoptosis;inhibitor;innovation;Investments;jagged1 protein;Lead;leukemia;Leukemic Cell;leukemic stem cell;manufacture;manufacturing run;Mediating;Medical;meetings;mouse model;Mus;Mutation;Myelogenous;Nature;notch protein;novel;novel strategies;older patient;Oncogenic;Oryctolagus cuniculus;Osteoblasts;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;Population;postnatal;Process;Production;programs;Proliferating;Rattus;Regimen;Relapse;Reporting;Research;Risk;Sampling;side effect;Signal Transduction;Source;standard of care;stem cell therapy;Survival Rate;System;targeted treatment;Testing;Therapeutic;Time;Toxicity due to chemotherapy;Toxicology;tumor microenvironment;Tumor Stem Cells;Unfavorable Clinical Outcome;Universities;Up-Regulation;Work

PROJECT_TITLE: A novel approach for treating myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDPT-R (12)]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: BEAVERTON

ORG_NAME: TEO THERAPEUTICS INCORPORATED

ORG_STATE: OR

PHR: PROJECT NARRATIVE This project designs, creates and implements a novel tool for welfare and management of research animals -- increasing the speed of preclinical research while also responding to federally-legislated mandates to reduce the use of mammalian animal models. The tool we propose is the shell-free quail egg assay for testing promising new drugs against human tumor cells in an easy-to-use plate-based kit format.

PI_NAMEs: KELLER, CHARLES  (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: 3D Print;Academia;Acceleration;Address;Adoption;Adult;Aluminum;Animal Experimentation;Animal Model;Animals;Antineoplastic Agents;Arteries;Attention;Benchmarking;Biological Assay;Biomimetics;Blood;Budgets;Cancer cell line;cancer type;capillary bed;Capital;Cell Line;Cells;Chemicals;chicken egg;Clinical;Comparative Study;Congresses;Connective Tissue;cost;Custom;Data;Dedications;design;Detection;Devices;Dose;Drug Delivery Systems;drug development;drug discovery;Drug Industry;drug testing;Early identification;effective therapy;Effectiveness;effectiveness evaluation;egg;Engineering;Environment;Equation;Equity;Expenditure;experience;experimental study;FDA approved;fiberglass;Friends;germ free condition;Human;Hydrogels;IACUC;imager;Imaging Device;improved;In Vitro;in vivo;in vivo imaging system;Incubators;innovation;instrument;Investments;Laboratories;laboratory development;Lead;Legal patent;Link;Luciferases;luciferin;luminescence;Lung;Lymphatic;Malignant Childhood Neoplasm;Malignant Neoplasms;manufacture;Medical;Membrane;Microscope;Modeling;Mouse Strains;Mus;neoplastic cell;novel;novel therapeutics;Nutrient;Oncology;Organoids;Performance;Perfusion;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Physiological;pre-clinical;pre-clinical research;preclinical development;preclinical study;Preclinical Testing;Process;Protocols documentation;prototype;Quail;rare cancer;Recovery;Reproducibility;research and development;response;Rodent;scaffold;Shipping;Speed;Statutes and Laws;success;System;Temperature;Testing;Therapeutic;Time;tissue culture;tool;tumor microenvironment;Validation;Veins;Vision;Weight;welfare;Xenograft procedure;zygote

PROJECT_TITLE: Reimagining Pharmaceutical Drug Development in Oncology with a Biomimetic Platform


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: CHEMISTRY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Project Narrative Iron-containing enzymes carry out a bewildering array of (often chemically difficult) transformations, of which many are of particular importance to human health, such as biosynthesis of many antibiotics, DNA biosynthesis, control and regulation of oxygen levels, and gene regulation. In our research we utilize a combination of experimental and theoretical methods to study the mechanisms of these reactions on a detailed, atomic level. Ultimately, we aim at rationally reprogramming iron-containing enzymes with the aim of harnessing and enhancing their potential for society.

PI_NAMEs: KREBS, CARSTEN  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TITLE: Mechanisms of Iron-Containing Enzymes


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Pediatric

ORG_CITY: SAN ANTONIO

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PUBLIC HEALTH RELEVANCE STATEMENT The enamel malformation Molar-incisor hypomineralization (MIH) debilitates children through chalky white to yellow spots, brittle enamel and dental sensitivity. We propose studies to determine the pathogenesis of these defects and to find precise, effective therapy.

PI_NAMEs: CHUN, YONG-HEE PATRICIA (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Address;Adherens Junction;Affect;ameloblastin;Ameloblasts;Amelogenesis;Amelogenesis Imperfecta;ATAC-seq;Basic Science;bioinformatics tool;Cells;Child;claudin-1 protein;Clinical Research;Complex;conditioning;Country;deciduous tooth;Defect;density;Dental;Dental caries;Dental Enamel;design;Development;Diffuse;Distal;effective therapy;Enamel Formation;Enamel Organ;Enzymes;Epithelial Cells;Epithelium;Esthetics;Exposure to;fluorosis;Functional disorder;Hardness;Health;Height;Histology;Hydroxyapatites;Immunohistochemistry;In Situ Hybridization;In Vitro;Incisor;Infiltration;Ion Transport;Lesion;malformation;matrigel;Maturation-Stage Ameloblast;Membrane;microCT;mineralization;Minerals;minimally invasive;MMP-20;Molecular Weight;mouse model;mRNA Expression;multiple omics;Mus;nano;overexpression;Pathogenesis;Pathway interactions;permanent tooth;Phosphoric Acids;Population;Porosity;Positioning Attribute;pre-clinical research;Predisposition;preservation;Process;protein expression;Proteins;public health relevance;reconstitution;Research;Residual state;scaffold;Serum;Spottings;Surface;targeted treatment;Tight Junctions;Tissues;Tooth Demineralization;Tooth structure;Toxic Environmental Substances;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;Translating;Treatment Protocols;Western Blotting

PROJECT_TITLE: Enamel with overexpressed ameloblastin

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative Improving the scientific community's ability to fundamentally understand the behavior of biological systems requires the development of protein tools that report or modify biological processes. This project will aid the development of protein tools by creating a large scale protein screening technology that uses optical methods to provide both the detailed genetic sequence and functional merit of many individual protein tool variants in parallel. The proposed technology will impact the protein tool engineering field by better selecting high-performing tool candidates or predicting key changes that would improve protein tools.

PI_NAMEs: GONG, YIYANG  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Algorithmic Analysis;Amino Acid Sequence;Amino Acids;Bar Codes;base;Behavior;Biological Process;biological systems;Biology;Biomedical Engineering;Biotechnology;Brain;Budgets;Calcium;candidate identification;Cells;Cellular biology;Chemistry;chromophore;Combinatorics;Communities;Community Developments;Data;Data Analyses;deep learning;design;Development;Developmental Biology;Dictionary;Directed Molecular Evolution;Discipline;DNA Sequence;Engineering;experimental study;Face;fitness;Genetic;Goals;Human Resources;Image;image processing;improved;In Situ;in situ sequencing;Individual;Knowledge;Libraries;Mammalian Cell;Messenger RNA;Modernization;Molecular Biology;Mutagenesis;mutant;Mutate;Mutation;Nature;Neurosciences;Neurotransmitters;open source;optical imaging;Optical Methods;Optics;Organism;Performance;Positioning Attribute;Preparation;prevent;Process;Property;protein function;Protein Region;protein structure;Proteins;Protocols documentation;Rapid screening;Reagent;red fluorescent protein;Reporting;Resolution;Resources;Running;Sampling;screening;Structure;Subcellular structure;System;Systems Biology;Techniques;Technology;Tissue imaging;tool;tool development;Translating;Variant;voltage

PROJECT_TITLE: Development of large-scale sequence-function relationship using in situ optical sequencing

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE: Overall Component This The Texas Medical Center Digestive Diseases Research Core Center serves an integrated and interdisciplinary research base of basic and clinical investigators performing research to understand digestive health and disease, and treat and prevent intestinal, liver and pancreatic disease. Scientific cores, pilot and feasibility grants and enrichment programs promote and facilitate collaborations and stimulate ideas and capabilities to advance science and increase productivity of our interactive research community.

PI_NAMEs: EL-SERAG, HASHEM B (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Adult;Area;base;Basic Science;Biological Models;Biology;Biomedical Research;Cancer Center;career development;Cellular biology;Childhood;Clinical;Clinical Investigator;Clinical Research;Collaborations;college;Communication;Communities;Digestive System Disorders;Direct Costs;Disease;Educational workshop;Ensure;Environment;epidemiology study;Equipment;Etiology;Experimental Models;Fellowship;flexibility;Focus Groups;Fostering;Foundations;functional genomics;Funding;Gastroenterology;gastrointestinal;gastrointestinal system;Goals;Grant;Growth;Health;Health Sciences;Hepatology;Individual;Infection;Infrastructure;Injury;innovation;insight;Institution;Interdisciplinary Study;interest;Intestinal Diseases;Leadership;Lesion;Liver diseases;Manuscripts;Medical center;Medicine;member;Metabolic dysfunction;Metabolism;Metagenomics;Microbiology;microbiome;Molecular;Molecular Biology;molecular imaging;Molecular Virology;Morphology;multidisciplinary;multimodality;National Institute of Diabetes and Digestive and Kidney Diseases;Notification;novel strategies;Organoids;Outcome;Outcomes Research;paligenosis;Pancreatic Diseases;Paper;Pathogenesis;Philosophy;Pilot Projects;Population Heterogeneity;Postdoctoral Fellow;posters;premalignant;prevent;Principal Investigator;Productivity;programs;Publications;Publishing;Qualifying;recruit;Rejuvenation;Research;Research Design;Research Personnel;Research Training;Science;Scientist;Services;stem cells;Students;symposium;System;Talents;Technology;Texas;Therapeutic;Tissues;tool;Training;United States National Institutes of Health;Universities;web based software;Work

PROJECT_TITLE: Texas Medical Center Digestive Diseases Center


NIH_SPENDING_CATS: Digestive Diseases

PHR: PROJECT NARRATIVE: Administrative Core Per instructions in RFA-DK-21-026, we have not included a project narrative in this application. As specified, we have included the narrative in the overall component.

PROJECT_TERMS: Administrator;Advisory Committees;base;Biomedical Technology;Cancer Center;Clinical;college;Communication;Data;Databases;Decision Making;Development;Digestive System Disorders;Doctor of Philosophy;Elements;Eligibility Determination;Ensure;Evolution;experience;Fostering;Funding;Goals;Growth;Health Sciences;Human Resources;Information Dissemination;Information Technology;Infrastructure;innovation;Institution;Instruction;Leadership;Medical center;Medicine;member;Monitor;Monkeys;multimodality;new technology;Occupational activity of managing finances;Online Systems;operation;Policies;posters;Procedures;Process;Productivity;programs;Progress Reports;Publications;Records;Rejuvenation;Research;Research Personnel;Resources;Running;Services;Specific qualifier value;Strategic Planning;Structure;success;Surveys;symposium;System;technology/technique;Texas;Travel;United States National Institutes of Health;Universities;virtual;Washington;web site

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Nutrition;Obesity;Physical Activity;Prevention;Telehealth

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Weight regain after weight loss is the most significant challenge in obesity treatment. This study will examine the effects of a novel digital health intervention and stepped care approach on weight loss maintenance. The results have significance for contributing to more scalable models of obesity treatment.

PI_NAMEs: CHAO, ARIANA MARIE (contact)

PROGRAM_OFFICER_NAME: GIVENS-BRADLEY, SHANNON SHAREE

PROJECT_TERMS: Accelerometer;Address;Adherence;adult obesity;Behavior;Behavior Control;Behavior Therapy;Body Weight;Body Weight decreased;Calories;Caring;Chronic;clinical practice;clinically significant;comorbidity;compliance behavior;cost;Counseling;Diet;digital health;digital tool;E-learning;Eating Behavior;economic evaluation;Education;Effectiveness of Interventions;Electronic Mail;Energy Intake;Failure;Feedback;flexibility;Frequencies;Goals;group intervention;Healthcare;Heterogeneity;implementation cost;improved;incremental cost-effectiveness;Individual;individual response;Intake;Intervention;Life Style;lifestyle intervention;Maintenance;Methods;Modeling;Monitor;Nature;novel;Obesity;obesity management;obesity treatment;Outcome;Outcome Study;Participant;patient oriented;patient response;Patient Self-Report;Patients;Persons;Phase;Physical activity;primary outcome;Professional counselor;programs;Provider;Randomized;Relapse;remote monitoring;Research;Resources;response;Schedule;success;telemonitoring;Telephone;Text;Text Messaging;theories;therapy design;Time;tool;treatment as usual;treatment response;Visit;Weight;weight loss intervention;weight maintenance;Weight maintenance regimen;wireless fidelity

PROJECT_TITLE: Stepped Care for Weight Loss Maintenance

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: ATLANTA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Project Narrative This project entails using systems-scale characterization of a “cell-free” biological system to understand its metabolic behavior as well as how and why it stops working. Improved understanding of this system could allow for the development of more effective low-cost diagnostics, improved abilities to discover and produce therapeutics, and more effective and realistic test tube studies of how organisms function.

PI_NAMEs: STYCZYNSKI, MARK PHILIP-WALTER (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Adoption;Behavior;Biological;biological systems;Biomedical Engineering;Biosensor;Biotechnology;Cell-Free System;Cells;Complement;computerized tools;cost;Data;Data Analyses;Development;Diagnostic;Engineering;Equipment;experimental study;Goals;improved;in vitro Model;in vivo;insight;Laboratories;Malnutrition;Masks;Measurement;Metabolic;metabolic abnormality assessment;Metabolism;metabolomics;Modeling;Organism;Productivity;Proteomics;Reaction;Regulation;Research Project Summaries;Residual state;Resource-limited setting;synthetic biology;System;Systems Biology;Testing;Therapeutic;tool;Tube;Vision;Work

PROJECT_TITLE: Systems Biology to Unlock the Next Level of Cell-Free Synthetic Biology


PHR: PROJECT NARRATIVE: Tissue Analysis and Molecular Imaging Core (TAMI) Per instructions in RFA-DK-21-026, we have not included a project narrative in this application. As specified, we have included the narrative in the overall component.

PI_NAMEs: MILLS, JASON C (contact)

PROJECT_TERMS: 3-Dimensional;Anatomy;Animal Model;animal tissue;Antibodies;Area;Bioinformatics;Biological Models;Biomedical Research;Board Certification;Cancer Center;Cells;Clinical;college;Communities;community center;Complex;Computer software;Confocal Microscopy;Consult;Consultations;Coupled;Data;data acquisition;Data Analyses;Digestive System Disorders;digital imaging;Disease;Doctor of Philosophy;Electron Microscopy;Ensure;Experimental Designs;Experimental Models;fluorophore;Fostering;functional genomics;Funding;gastrointestinal;Genes;Goals;Group Meetings;Health;Health Sciences;high throughput screening;Histocytochemistry;Histologic;Histology;Histopathology;Human;human tissue;Image;Image Analysis;imaging capabilities;Imaging Device;Imaging technology;In Situ Hybridization;Institution;Instruction;instrument;instrumentation;interest;laser capture microdissection;Leadership;live cell imaging;Liver;Medical center;Medicine;member;Messenger RNA;Methods;microbiome;Microscope;Microscopy;Microtomy;Mission;Molecular;molecular imaging;Morphology;National Institute of Diabetes and Digestive and Kidney Diseases;new growth;operation;Organelles;Organoids;Pathologic;Pathologist;Pathology;Phase;Phenotype;Play;Production;programs;Proteins;Publications;Research;Research Personnel;Resources;Role;Sampling;Scanning;Scientist;service utilization;Services;Signal Transduction;Specific qualifier value;Stains;superresolution microscopy;symposium;synergism;Techniques;Technology;Texas;time use;Tissue Embedding;Tissue imaging;tissue preparation;tissue processing;Tissues;Titrations;Training;transcriptomics;Translational Research;ultra high resolution;Universities;Update;Washington;Work

PROJECT_TITLE: Tissue Analysis & Molecular Imaging Core


NIH_SPENDING_CATS: Arthritis;Chronic Pain;Dental, Oral, and Craniofacial Disease;Pain Research;Precision Medicine;Temporomandibular Muscle/Joint Disorder (TMJD);Women's Health Research

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: Project Narrative The proposed research uniquely quantifies easily measured variables that are predictive of longitudinal changes in temporomandibular joint (TMJ) integrity. This research has potential for high payoffs with respect to the translation of findings to clinical practice. We will identify easily measured anatomical and psychophysiological risk factors that promote the precocious development of degenerative joint disease of the TMJ, and elucidate the reasons for its higher prevalence in females compared to males.

PI_NAMEs: GONZALEZ-STUCKER, YOLY M (contact)

PROJECT_TERMS: Address;Affect;American;Anatomy;Animal Model;Area;Arithmetic;articular cartilage;Behavior;Biological Markers;Cephalic;Characteristics;Clinical;clinical practice;clinical translation;cohort;cone-beam computed tomography;Consensus;cost;Data;Data Set;Degenerative Disorder;Degenerative polyarthritis;Development;Diagnosis;Diagnostic;Disease Progression;energy density;Engineering;Environment;Failure;Fatigue;Female;Frequencies;Goals;Head;Health;High Prevalence;Hip region structure;Human;Image;improved;Individual;Jaw;joint loading;Joints;Knee;Length;male;Mandibular Condyle;Measurement;Measures;Mechanics;Medicine;Morphology;Muscle;National Institute of Dental and Craniofacial Research;Nickel;Occlusal Planes;Outcome;Pain;Patients;Pilot Projects;predictive marker;Predisposition;premature;Psychophysiology;Publishing;Questionnaires;Reporting;Research;Risk;Risk Factors;Same-sex;Sex Differences;Structure;Temporomandibular Joint;Temporomandibular Joint Disorders;Testing;Time;Tissues;TMJ disk displacement;tool;Translations;United States National Academy of Sciences;women versus men;Women's prevalence;Work

PROJECT_TITLE: Predictive Markers for Longitudinal TMJ Integrity


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE This project will assess how local economic conditions shape patterns of family instability and complexity, with attention to how these processes developed over historical time and vary by race and social class. The findings will be critically important for understanding population health patterns because the family environment shapes parent and child well-being across the life span. Additionally, social and economic change are experienced unequally by race and social class; thus, associations of poor local economic conditions with family instability and complexity may contribute to inequality between families.

PI_NAMEs: HAYS, JAKE J. (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Address;Adult;Affect;Area;Attention;Behavior;Birth;black men;black women;career;Child;Child Health;Child Welfare;Cluster Analysis;college;Complex;County;Data;Data Analyses;Data Sources;Development;Economic Conditions;Economic Factors;Economics;Education;Educational Status;Employment;Environment;Event;experience;Exposure to;Family;Family Demographies;family structure;Fellowship;First Births;Goals;Grant;Health;health disparity;Imprisonment;Income;Inequality;innovation;Institution;intergenerational;life span;Link;local economy;Location;male;manufacture;Measures;men;Mentors;Methods;Modeling;Nuclear Family;Occupational;Occupations;panel study of income dynamics;parental influence;Parents;Pattern;Personal Satisfaction;Population Dynamics;population health;post-doctoral training;Process;Race;racial disparity;Research;Research Project Grants;Selection Bias;Sequence Analysis;Services;Shapes;social;Social Class;Social Conditions;social factors;Stepfamilies;Structural Models;Structure;symposium;Tail;Techniques;Testing;Time;Training;transmission process;Unemployment;Universities;Variant;Wages;Woman;Writing

PROJECT_TITLE: Local Economic Conditions and Patterns of Family Instability and Complexity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-A(20)L]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Digestive Diseases;Genetics;Human Genome;Liver Disease;Machine Learning and Artificial Intelligence;Microbiome;Networking and Information Technology R&D (NITRD)

PHR: PROJECT NARRATIVE: Functional Genomics and Microbiome Core (FGM) Per instructions in RFA-DK-21-026, we have not included a project narrative in this application. As specified, we have included the narrative in the overall component.

PI_NAMEs: VERSALOVIC, JAMES  (contact)

PROJECT_TERMS: Affect;analysis pipeline;Artificial Intelligence;artificial intelligence model;Bacteriophages;Bioinformatics;bioinformatics tool;Biological;Biology;Biomedical Research;Biometry;Capital;Cell Communication;Cell Separation;Cells;ChIP-seq;Chromium;Consultations;Coupled;Coupling;Data;data analysis pipeline;data integration;Digestive System Disorders;Disease;DNA;Doctor of Philosophy;Epigenetic Process;epigenomics;Evaluation;Experimental Designs;functional genomics;Funding;gastrointestinal;Gastrointestinal Diseases;Gene Expression;Gene Expression Profile;Generations;Genes;genomic platform;Genomics;Goals;Hepatic;Hepatobiliary;Hepatology;host microbiome;Human;Immune response;Infection;Injury;innovation;insight;Institution;Instruction;instrumentation;Intestines;large scale data;liquid chromatography mass spectrometry;Liquid substance;Liver;Liver diseases;Mammalian Cell;Maps;Mass Spectrum Analysis;Medical center;member;Metabolic;Metabolism;metabolomics;Metagenomics;microbial;microbiome;microbiome research;Mission;Molecular;molecular modeling;multiple omics;Mus;nanopore;Nucleic acid sequencing;Organoids;Pathway interactions;Pattern;Population;Problem Solving;programs;protein profiling;Proteins;Proteomics;Publications;quantum;Research;Research Personnel;Resolution;Resource Sharing;Resources;response;Ribosomal RNA;Services;Shotgun Sequencing;Signal Pathway;Signal Transduction;Specific qualifier value;Specimen Handling;supercomputer;Systems Biology;Technology;Texas;Tissue-Specific Gene Expression;Tissues;tool;transcriptome sequencing;transcriptomics;Translational Research;Viral;Viral Genes;virome;Whole-Genome Shotgun Sequencing

PROJECT_TITLE: Functional Genomics & Microbiome Core


ORG_CITY: DALLAS

ORG_DEPT: SURGERY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative  While immune dysfunction after a significant inflammatory insult, such as trauma or sepsis, has been extensively described, no one has been able to reverse its progression. As a result, the recovery for critically ill patients can be intense and involve prolonged hospitalizations marked by multiple complications, poor wound healing, profound disability, and long-term deficits. This proposal investigates novel ways to profile individuals' immune responses with the hopes of developing personalized immune therapies to improve outcomes for a variety of critically ill patients.

PI_NAMEs: NOMELLINI, VANESSA  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Acute;Adaptive Immune System;Admission activity;Animals;Basic Science;Blood specimen;bone cell;Bone Marrow;Caring;Cells;Chronic;Critical Illness;disability;Failure;Health Care Costs;Healthcare;Hospitalization;Human;Immune;Immune response;Immune System Diseases;immunosuppressed;Immunosuppression;Immunotherapy;improved;improved outcome;Individual;Infection;Inflammatory;Injury;Innate Immune System;Investments;mouse model;Mus;novel;Operative Surgical Procedures;Outcome;Patient Admission;Patient-Focused Outcomes;Patients;Phenotype;Physicians;prevent;primary outcome;Recovery;Regression Analysis;Research Personnel;response;response to injury;Risk Factors;Sepsis;Source;Supportive care;Survival Rate;Survivors;synergism;Trauma;wound healing

PROJECT_TITLE: Utilizing Immune Phenotypes to Prevent Chronic Critical Illness

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Rehabilitation;Stroke

ORG_CITY: BOSTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: In this project, we use computational modeling to characterize and understand how bilingual lexical and semantic language abilities recover in post-stroke aphasia and how they decline in dementia. This project is uniquely significant and innovative because it identifies both the factors that determine language proficiency (age of acquisition, use, and exposure) in bilinguals, and the mechanisms that cause the impairment across two different neurological disorders (stroke and dementia). Successful outcomes of this work will provide us with a mechanistic understanding of language impairment, recovery and decline in neurological disorders.

PI_NAMEs: KIRAN, SWATHI  (contact);MIIKKULAINEN, RISTO

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Adult;Age;aged;Aphasia;Area;Behavior;bilingualism;Censuses;Child;Clinical;Clinical Services;Clinical Trials;Computer Models;Computer Simulation;Data;Dementia;Exhibits;Familiarity;flexibility;Foundations;healthy aging;Hispanic;Hispanic Populations;Human;Impairment;improved;Incidence;Individual;innovation;insight;Language;language impairment;language processing;Lateral;Latino Population;lexical;lexical retrieval;Linguistics;Maps;Modeling;Names;natural language;Nature;Nervous System Disorder;Neurodegenerative Disorders;Neurologic;older adult;Outcome;Patients;Pattern;Population;post stroke;Prediction of Response to Therapy;Process;Recovery;Rehabilitation Outcome;Rehabilitation therapy;response;Route;Semantic Dementias;semantic processing;Semantics;Spanish/English;Specificity;statistics;Stroke;stroke patient;stroke recovery;stroke-induced aphasia;Structure;Survivors;System;Time;Translations;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Computational modeling of language impairment and control in bilingual individuals with post-stroke aphasia and neurodegenerative disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-N(02)M]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Microbiome;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

PHR: PROJECT NARRATIVE: Gastrointestinal Experimental Model Systems Core (GEMS) Per instructions in RFA-DK-21-026, we have not included a project narrative in this application. As specified, we have included the narrative in the overall component.

PI_NAMEs: BLUTT, SARAH E (contact)

PROJECT_TERMS: Animal Model;Animals;Biological Models;Biological Monitoring;Biomedical Research;cell type;Clinical Research;Clinical Trials;Complex;Conditioned Culture Media;cost;Development;Digestive System Disorders;Disease;Doctor of Philosophy;Embryo Transfer;Ensure;Environment;Epithelium;experience;Experimental Models;experimental study;Freezing;functional genomics;Funding;gastrointestinal;Gastrointestinal tract structure;Germ-Free;Gnotobiotic;Goals;Growth;Health;Heterogeneity;Homeostasis;Housing;Human;human pluripotent stem cell;Human Resources;improved;in vivo;Individual;Infection;Injury;Instruction;interest;Intestines;Leadership;Medical center;member;Metabolism;Microbe;microbial;microbial community;microbial composition;microbiome;Mission;Modeling;molecular imaging;mouse model;Mus;Operative Surgical Procedures;Organ;Organism;organizational structure;Organoids;outreach;Patients;Physiology;Pre-Clinical Model;Protocols documentation;Publications;Quality Control;Reagent;Research;Research Design;Rodent;Services;Signal Transduction;Specific qualifier value;Specimen;Standardization;stem cell organoids;stem cells;Stromal Cells;System;Technology;Technology Transfer;Texas;Time;tissue stem cells;Tissues;Training;training project;Validation


NIH_SPENDING_CATS: Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Microbiome;Precision Medicine;Prevention

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Although substantial evidence demonstrating that low-dose aspirin (LDA) reduces risk of colorectal cancer (CRC) and likely other cancers has led to formal recommendations for LDA to prevent CRC, there remains a high unmet need to provide to develop precision biomarkers to optimize targeting populations for treatment with a favorable risk-benefit ratio. In this Outstanding Investigator Award, I propose a Precision Prevention Research Program to enhance molecularly characterized prospective cohort studies to test hypotheses that can then be tested for causality through cost-efficient, biomarker-driven clinical cohorts in which human tissues can be leveraged to develop “living biobanks” for rapid translational testing. These complementary approaches will empower my research team to study the entire continuum from healthy individuals to advanced cancer patients and from single cells to large populations to obtain a more complete, multifaceted view of how interventions can be tailored to prevent cancer.

PI_NAMEs: CHAN, ANDREW T (contact)

PROGRAM_OFFICER_NAME: UMAR, ASAD

PROJECT_TERMS: Advanced Malignant Neoplasm;Adverse effects;Age;anticancer activity;Aspirin;Award;biobank;Biological Markers;biomarker driven;Cancer Patient;cancer prevention;career;Cells;Chemoprevention;Clinic;Clinical;Clinical Trials;cohort;colorectal cancer prevention;colorectal cancer risk;cost efficient;Data;Dedications;Dose;Effectiveness;empowerment;Etiology;evidence base;Future;Goals;gut microbiome;Harm Reduction;Hemorrhage;human data;human tissue;improved;Individual;individualized prevention;Integration Host Factors;International;Intervention;Investigation;Malignant Neoplasms;Modeling;Molecular;Molecular Epidemiology;novel;novel strategies;Oncology;Patients;personalized approach;Physicians;Population;Population Study;prevent;Prevention approach;Prevention Research;preventive intervention;programs;Prospective, cohort study;rapid testing;Recommendation;Reporting;Research;Research Personnel;research vision;Resolution;Risk Reduction;risk stratification;risk/benefit ratio;Source;System;Target Populations;Testing;tool;United States Preventative Services Task Force;Validation;Work

PROJECT_TITLE: Precision Prevention Research Program


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Machine Learning and Artificial Intelligence

PHR: PROJECT NARRATIVE: Study Design and Clinical Research Core (Clinical Core) Per instructions in RFA-DK-21-026, we have not included a project narrative in this application. As specified, we have included the narrative in the overall component.

PI_NAMEs: KANWAL, FASIHA  (contact)

PROJECT_TERMS: Achievement;Applications Grants;Area;Artificial Intelligence;Award;Basic Science;biobank;Biological Models;Biometry;Clinical;Clinical and Translational Science Awards;Clinical Investigator;Clinical Research;Clinical Sciences;Clinical Trials;Collection;college;Confidentiality of Patient Information;Consultations;COVID-19 pandemic;dashboard;Data;Data Analyses;Data Collection;data management;Databases;Development;Digestive System Disorders;Disease;disease registry;Electronics;Ensure;Epidemiology;epidemiology study;experience;Experimental Models;Exposure to;functional genomics;Funding;Gastroenterology;gastrointestinal;Gastrointestinal Injury;Goals;Growth;Health;Health Service Area;Health Services;Health Services Research;Healthcare;Heavy Metals;Hepatology;Hour;Human;Human Resources;human tissue;Inflammation;Institutional Review Boards;Instruction;Investigational New Drug Application;Laboratories;Laboratory Finding;Lesion;Link;liver injury;Machine Learning;Medical center;Medicine;meetings;member;Metal exposure;Methods;microbiome;Modeling;molecular imaging;National Institute of Diabetes and Digestive and Kidney Diseases;neoplastic;Organoids;Outcome;Outcomes Research;Patients;Peer Review;Population;Preparation;Procedures;professor;programs;Protocols documentation;Publications;recruit;repository;Research;Research Design;Research Personnel;Resources;Risk Factors;Role;sample collection;Sampling;Science;Scientific Inquiry;Services;Specific qualifier value;Specimen;Statistical Data Interpretation;statistical service;stool sample;synergism;Texas;Tissue Banks;Tissue Sample;Tissues;Training;Training and Education;Training Programs;Translating;translational pipeline;Translational Research;translational study;United States National Institutes of Health

PROJECT_TITLE: Clinical Research & Study Design Core


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: BALTIMORE VA MEDICAL CENTER

PHR: Antibiotic-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) increase patient morbidity and mortality. Thus, they are an important public health concern. MRSA infections are responsible for over 100,000 U.S. hospitalizations each year and cause more deaths each year than human immunodeficiency virus (HIV) infection. Patients with MRSA infections have a two-fold higher risk of death compared to patients with susceptible infections. The use of gloves and gowns/contact precautions by healthcare workers aims to prevent patients from acquiring MRSA infections from other patients. However, tremendous controversy exists about the pros and cons of contact precautions. The proposed work will lead to a greater understanding of the factors associated with transmission of these bacteria and more cost-effective use of gloves and gowns/contact precautions to prevent the transmission of antibiotic-resistant bacteria.

PI_NAMEs: HARRIS, ANTHONY D (contact)

PROJECT_TERMS: acute care;Address;Admission activity;Antibiotic Resistance;Bacteria;Bacterial Antibiotic Resistance;career;Caring;Cessation of life;Clothing;Cohort Studies;Collaborations;Communicable Diseases;comorbidity;comparative cost effectiveness;cost;cost effective;cost effectiveness;Country;COVID-19 pandemic;cultural health;Data;Deimplementation;Development;effective intervention;effectiveness evaluation;Enrollment;Ensure;Epidemiology;evidence base;Funding;Geography;Goals;Hand;health care settings;Health Personnel;Health Services;Healthcare;high risk;HIV;Hospitalization;Hospitals;Infection;Infection Control;innovation;Institutionalization;Intensive Care Units;International;Journals;Knowledge;Medical;Medical center;meetings;member;methicillin resistant Staphylococcus aureus;Methodology;Modeling;Morbidity - disease rate;mortality;mortality risk;Outcome;participant enrollment;pathogen;Patient Care;patient population;Patient risk;Patients;Peer Review;Perception;personal protective equipment;Policies;Policy Analysis;Predisposition;prevent;Prevention;productivity loss;Public Health;Publishing;Recommendation;Relaxation;Research;Research Personnel;Risk;Risk Factors;Science;Severity of illness;Site;Societies;Solid;Staphylococcus aureus infection;symposium;Time;Translations;transmission process;United States;Virus Diseases;Work

PROJECT_TITLE: Targeted Contact Precaution Use to Prevent MRSA Transmission

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE Strikingly, 40% of heart failure (HF) patients are readmitted within 1-year following their first HF admission. One of the most common causes of HF readmission is lack of chronic medication optimization. The objectives of this proposal are to: (1) determine the effects of an adaptive medication optimization web application on guideline-directed medication prescribing in HF, (2) assess concordance between the recommendations provided by the medication optimization algorithm and the medications prescribed, and (3) identify the patient and provider characteristics that moderate the effectiveness of the medication optimization web application.

PI_NAMEs: DORSCH, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: TERAN, MARIO

PROJECT_TITLE: The Impact of an Adaptive Patient-Centered Web Application on Medication Optimization in HFrEF Patients

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


NIH_SPENDING_CATS: Brain Disorders;Cancer;Childhood Leukemia;Down Syndrome;Genetics;Hematology;Intellectual and Developmental Disabilities (IDD);Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: PROJECT NARRATIVE My laboratory is at the forefront of studies in leukemia in children with Down syndrome and in the role of megakaryocytes in myelofibrosis. In this project, we will leverage our expertise to compare the mechanisms of leukemia progression in pediatric and adult pre-leukemia disorders. Our work will shed new light on the biology of leukemia progression and may reveal novel strategies to treat or prevent transformation of these clonal disorders.

PI_NAMEs: CRISPINO, JOHN D (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Megakaryocytic Leukemias;Acute Myelocytic Leukemia;Adult;Animal Model;Biology;Chemoprevention;Childhood;Childhood Leukemia;Chromosome 21;CRISPR screen;Development;Disease;Disparate;Down's Syndrome;Event;GATA1 gene;Genes;Genetic;Hematological Disease;Hematopoiesis;Hematopoietic;insight;Laboratories;leukemia;Malignant - descriptor;Malignant Neoplasms;Megakaryocytes;Mutation;Myelofibrosis;Myeloproliferative disease;new therapeutic target;novel strategies;novel therapeutics;Pathogenesis;Pathway interactions;Patients;Preleukemia;prevent;Prevention strategy;Role;Sampling;tumor;Tumor Suppressor Genes;Work

PROJECT_TITLE: Identifying the mechanisms of leukemia progression


PHR: PROJECT NARRATIVE: Pilot Feasibility Program Per instructions in RFA-DK-21-026, we have not included a project narrative in this application. As specified, we have included the narrative in the overall component.

PI_NAMEs: BURRIN, DOUGLAS G (contact)

PROJECT_TERMS: Adult;Advisory Committees;Area;Award;Cancer Center;career;career development;Categories;Childhood;Collaborations;college;Committee Members;Communities;Complement;Coupled;Data;Development;Digestive System Disorders;Direct Costs;Doctor of Medicine;Doctor of Philosophy;Eligibility Determination;Environment;Extramural Activities;Faculty;feasibility testing;Fostering;Funding;Goals;Grant;Health Sciences;Human Resources;innovation;Institution;Instruction;Investments;Knowledge;Letters;Medical center;Medicine;meetings;member;Mentorship;Monitor;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;NIH Program Announcements;novel strategies;Outcome;Peer Review;Phase;Process;Productivity;programs;Publications;Qualifying;recruit;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Review Committee;Role;Scientific Evaluation;Scientist;Services;Specific qualifier value;Study Section;success;System;Testing;Texas;Training Programs;United States National Institutes of Health;Universities;University of Texas M D Anderson Cancer Center;web portal;web site;Work

PROJECT_TITLE: Pilot Feasibility Program


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Diabetes;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Social Determinants of Health;Women's Health Research

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Gestational diabetes (GDM) is a type of diabetes that develops during pregnancy that increases the risk of pregnancy and birth complications. New tests may allow doctors to identify women with GDM earlier and more accurately than the tests currently being used, but we need to understand them better. We will recruit 400 pregnant women and screen them using both traditional and new GDM screening tools at 12, 20, and 28 weeks of pregnancy to determine how well these tools identify women who are at risk of complications and need treatment.

PI_NAMEs: LEBLANC, ERIN S (contact);VESCO, KIMBERLY KRISTINE

PROGRAM_OFFICER_NAME: BROADNEY, MIRANDA MARGUERITE

PROJECT_TERMS: Adipose tissue;Affect;Age;Biological Assay;Biological Markers;biomarker identification;Birth;Birth Weight;Brachial plexus structure;C-Peptide;C-reactive protein;Cesarean section;Child;Clinical;Continuous Glucose Monitor;Data;delivery complications;Deposition;Detection;Development;Diabetes Mellitus;Diagnosis;Disparity;Dystocia;early pregnancy;Ensure;Environment;ethnic minority;ethnic minority population;experience;Fasting;fetal;First Pregnancy Trimester;Fracture;Functional disorder;Future;Gestational Age;Gestational Diabetes;Glucose;glycation;Glycosylated hemoglobin A;Hawaii;Health;high risk;Hyperglycemia;Hypertriglyceridemia;improved;Infant;Inflammation;Injury;Insulin Resistance;intrauterine environment;Laboratories;Lead;Life Style;machine learning model;Measurement;Measures;Metabolic;Metabolic dysfunction;metabolic phenotype;metabolic profile;Morbidity - disease rate;mortality;Mothers;Neonatal Mortality;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;obesogenic;offspring;OGTT;Oral Administration;Oral Diagnosis;Organogenesis;Outcome;Outpatients;Participant;Perinatal;perinatal complications;perinatal outcomes;Phenotype;Placenta;Plasma;postpartum outcome;Postpartum Period;Pre-Eclampsia;Pregnancy;Pregnancy Complications;pregnancy hypertension;Pregnant Women;primary outcome;Qualifying;racial minority;racial minority population;rapid detection;recruit;Regimen;reproductive;Risk;Sampling;screening;Screening procedure;Shoulder;stillbirth;Symptoms;Technology;Testing;Third Pregnancy Trimester;Time;tool;Triglycerides;Uterus;Woman;women's diagnosis;Work

PROJECT_TITLE: ChartGlucose4Moms: Characterizing, by Trimester, Continuous Glucose Monitoring Measurements for determining effects on Maternal & Offspring Metabolic Sequelae


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Dissemination and Implementation Research;Health Services;Hematology;Neurosciences;Opioids;Orphan Drug;Pain Research;Prescription Drug Misuse;Rare Diseases;Sickle Cell Disease;Substance Misuse

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Sickle Cell Disease patients are living with a high burden of pain and high prescription opioid use. There are three priorities for this study: (1) evaluate the effectiveness of guided relaxation and acupuncture to improve pain control; (2) determine what is the most appropriate and effective treatment sequence for any given patient based on unique characteristics; and (3) describe the processes and structures required to implement guided relaxation and acupuncture into health care systems. Results from this research may reduce opioid use and improve pain management among sickle cell disease patients.

PI_NAMEs: DOORENBOS, ARDITH Z (contact);EZENWA, MIRIAM OMELEBELE;KNISELY, MITCHELL ROBERT;MATTHIE, NADINE ;MOLOKIE, ROBERT E;SCHLAEGER, JUDITH MICHELLE;SHAH, NIRMISH R;WILKIE, DIANA J

PROGRAM_OFFICER_NAME: JEAN-FRANCOIS, BEDA

PROJECT_TERMS: Accident and Emergency department;Acupuncture Therapy;Acute;adaptive intervention;Address;Admission activity;African;Age;Alternative Therapies;Anxiety;arm;Caring;Characteristics;Chronic;chronic pain;chronic pain management;Clinic;Clinical;Clinical and Translational Science Awards;Collaborations;collaboratory;Companions;Complementary Health;Complementary therapies;Consolidated Framework for Implementation Research;coping;Data;Data Collection;depressive symptoms;design;effective therapy;Effectiveness;effectiveness evaluation;effectiveness/implementation trial;Electronic Health Record;Ensure;Evaluation;Exposure to;Florida;Health;Health Care Costs;Health Sciences;Health system;Healthcare Systems;Hispanic;Hospitalization;Hospitals;Hybrids;Illinois;implementation evaluation;implementation facilitators;implementation process;improved;improved outcome;Individual;information gathering;Insurance;Insurance Coverage;Integrative Medicine;Integrative Therapy;Intervention;Medicare/Medicaid;Opioid;opioid therapy;opioid use;Outcome;Pain;pain catastrophizing;Pain management;pain reduction;Patient Care;patient population;Patients;Persons;Pharmaceutical Preparations;Phase;Policies;Population;Pragmatic clinical trial;pragmatic trial;prescription opioid;Prescription opioid overdose;Privatization;Procedures;Process;Protocols documentation;Public Health;Randomized;Randomized, Controlled Trials;recruit;Relaxation;Research;response;Safety;sex;Sickle Cell Anemia;side effect;Site;Sleep;Speed;Structure;Symptoms;System;Testing;Translations;treatment as usual;United States;United States National Institutes of Health;Universities

PROJECT_TITLE: Hybrid Effectiveness-Implementation Trial of Guided Relaxation and Acupuncture for Chronic Sickle Cell Disease Pain

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Serious Mental Illness

ORG_CITY: SAN FRANCISCO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative The proposed research is relevant to public health because understanding of the neural mechanism by which meditation training improves emotional health in healthy and depressed adolescents is ultimately expected to help us develop safe and effective methods of treating and preventing adolescent depression. Thus, the proposed research is relevant to the part of NIH's mission to ensure that all youth have the chance to achieve their full potential for healthy and productive lives, free from disease or disability.

PI_NAMEs: YANG, TONY TUNG-I (contact)

PROGRAM_OFFICER_NAME: QUINLAN, ERIN BURKE

PROJECT_TERMS: Adolescence;Adolescent;adolescent health;Affect;Age;Anhedonia;Attenuated;Brain;Brain region;Caring;Characteristics;child depression;Clinical;Clinical Trials;cohort;comparison control;Compassion;connectome;Control Groups;Data;Depressed mood;depression prevention;depressive symptoms;design;Diffusion Magnetic Resonance Imaging;disability;Disease;effective intervention;effectiveness study;Emotional;expectation;experience;Goals;Happiness;Health;improved;indexing;innovation;Intervention;Knowledge;Literature;Love;Magnetic Resonance Imaging;Maps;Measures;Mediating;Mediation;Meditation;Mental Depression;Methods;mindfulness meditation;Mindfulness Training;Mission;Modeling;myelination;neural;neurodevelopment;neuromechanism;novel;Outcome;Participant;Patient Self-Report;Phase;pleasure;Population;positive emotional state;Prefrontal Cortex;prevent;Prevention;Primary Care;Productivity;Public Health;putamen;Questionnaires;Randomized;recruit;relapse prevention;Research;response;Sampling;Scanning;Severities;Symptoms;Techniques;Teenagers;Testing;Training;United States National Institutes of Health;Waiting Lists;Weight;white matter;Work;Youth

PROJECT_TITLE: Neural mechanisms of meditation training in healthy and depressed adolescents: An MRI connectome study


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Congenital Structural Anomalies;Contraception/Reproduction;Disability Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Prevention;Rare Diseases;Rehabilitation;Social Determinants of Health;Spina Bifida;Women's Health Research

ORG_DEPT: UROLOGY

PHR: PROJECT NARRATIVE With improved survival, more girls with born with physical disabilities are entering puberty, developing intimate relationships, and going on to have children. Although their disability impacts both their sexual health (e.g., allergy to latex condoms) and the way they learn (e.g., executive functioning limitations), they are not being educated about their sexual health, leading to poor long-term outcomes such as unintended pregnancies and low use of contraception. This project focuses on developing a user-centered, online sexual health educational intervention for girls with physical disabilities tailored to their unique learning style that addresses their highest priority sexual health topics.

PI_NAMEs: STREUR, COURTNEY S (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Address;Adolescent;Adoption;Adult;Age;American;career;career development;Caring;Child;Childhood;Clinical Trials;Cognitive;cognitive development;cognitive disability;cohort;comorbidity;condoms;Congenital Abnormality;Contraceptive methods;Contraceptive Usage;Contracture;Data;design;Development Plans;Diagnosis;disability;disability impact;Disabled Children;Disabling;dissemination science;Education;Educational Curriculum;Educational Intervention;effective intervention;Effectiveness;Ensure;Evaluation;executive function;experience;Feedback;Female;Female Adolescents;Frequencies;Funding;Future;Gatekeeping;girls;Goals;Gynecologic;Health education;health goals;health knowledge;Health Services;Healthy People 2020;Hydrocephalus;Hypersensitivity;Impairment;implementation framework;implementation measures;implementation outcomes;implementation science;improved;Incontinence;Intervention;Interview;intimate partner violence;Knowledge;Knowledge Management;Latex;Learning;Life Expectancy;Maintenance;Medical;Mentors;Methods;National Institute of Child Health and Human Development;neglect;Neural Tube Defects;novel;online intervention;Outcome;Parents;peer;physically handicapped;Pilot Projects;Population;post intervention;Precocious Puberty;Pregnancy Complications;prototype;Provider;Puberty;Public Health;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reproductive Health;Research;Research Personnel;Research Priority;Risk;Self Management;Sexual abuse;sexual coercion;Sexual Development;Sexual Health;sexual health intervention;Sexually Transmitted Diseases;skill acquisition;skills;Spinal Dysraphism;Surveys;Testing;therapy design;Time;Training;unintended pregnancy;Urologist;usability;Women's Group;Work;Writing

PROJECT_TITLE: Developing a reproductive health curriculum for adolescent girls with physical disabilities

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: There is a critical need to grow and strengthen the pipeline of physician scientists who have expertise in sociomedical and behavioral research and are dedicated to addressing the nation's challenges posed by Alzheimer's disease and related dementias (ADRD). The Indiana ADRD Medical Scientist Training Program was conceived to meet this need. This application leverages the strengths of our existing MD-PhD program and the ADRD research expertise at IUSM to train the next generation of physician scientists who will become leaders in ADRD research.

PI_NAMEs: CALLAHAN, CHRISTOPHER M;FOWLER, NICOLE R. (contact);HERBERT, BRITTNEY-SHEA

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Alzheimer's disease related dementia;Behavioral;Indiana;Medical;next generation;Physicians;Scientist;social;Training;Training Programs

PROJECT_TITLE: Training the Next Generation of Social and Behavioral Physician-Scientists in ADRD: The Indiana ADRD Medical Scientist Training Program


PHR: PROJECT NARRATIVE: Enrichment Program Per instructions in RFA-DK-21-026, we have not included a project narrative in this application. As specified, we have included the narrative in the overall component.

PI_NAMEs: PREIDIS, GEOFFREY A (contact)

PROJECT_TITLE: Enrichment Program


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Networking and Information Technology R&D (NITRD);Neurosciences;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSURGERY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE The present approach for brain injury monitoring employs multiple invasive brain probes with each probe providing a different measurement which must be individually visualized, analyzed and integrated by the physician. We will develop a brain monitoring solution (the “NeuroProbe Solution”) based on a single probe that will combine the function of multiple individual brain probes. The NeuroProbe Solution has many advantages over current solutions including improved safety, better total patient physiology data integration and a lower cost, and is, thus, expected to lead to improved monitoring and personalized care of patients with brain injury.

PI_NAMEs: SPENCER, DENNIS D (contact);ZAVERI, HITTEN P

PROGRAM_OFFICER_NAME: FRANKOWSKI, MEGAN MICHELLE

PROJECT_TERMS: Acute Brain Injuries;Age;Algorithms;bench to bedside;Biological;Biomedical Engineering;Blood;Blood Pressure;Brain;Brain Hypoxia;Brain Injuries;brain parenchyma;brain tissue;Caring;Cephalic;cerebral autoregulation;Clinical;clinical examination;cohort;Complex;computerized data processing;cost;Coupled;Critical Illness;Custom;Data;data acquisition;Data Analyses;Data Display;data exchange;data integration;data streams;Development;Devices;Diagnostic Equipment;Diameter;digital data;disability;Electrodes;Electroencephalography;Electronics;Engineering;Evaluation;fabrication;Failure;flexibility;Functional disorder;Goals;health economics;Heart Rate;Hemorrhage;Human;implantable device;improved;improved outcome;in vivo;Incidence;Individual;individualized medicine;Infection;Injury;innovation;instrumentation;Intensive Care Units;interest;Intracranial Pressure;Lifelong disability;Marketing;Mathematics;Measurement;Measures;Metabolic;Metabolism;Military Personnel;Modality;Monitor;mortality;multidisciplinary;multimodal data;multimodality;Nervous System Trauma;neural implant;Neurologic;neurophysiology;neurosurgery;Output;Oxygen;Patient Care;Patient risk;Patient-Focused Outcomes;Patients;personalized care;personalized medicine;Persons;Phase;Physicians;Physiologic Monitoring;Physiological;Physiology;Pilot Projects;population based;pressure;prevent;Provider;Public Health;Pulse Oximetry;Risk;Safety;safety assessment;safety testing;Scalp structure;Seizures;sensor;Signal Transduction;socioeconomics;software systems;Source;Stream;Survivors;System;Systemic blood pressure;Tablets;TBI Patients;TBI treatment;Technology;technology development;Temperature;Testing;Time;Training;Translating;transmission process;Trauma;trauma centers;Traumatic Brain Injury;Universities;usability;Vendor;Visualization;wounded soldier;young adult

PROJECT_TITLE: Intracranial multimodal physiological monitoring in acute brain injury

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders C Study Section[NSD-C]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Nutrition;Obesity;Prevention;Women's Health Research

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

PHR: NARRATIVE: Obesity is broadly associated with both increased incidences of a variety of cancers and a chronic inflammatory state. Our interdisciplinary team with expertise in cancer, obesity, microbiome, immunometabolism will test if obesity-altered gut microbes enhance cancer risk through dysregulated protective immunity which leads to changes in the immune milieu that increase cancer cell transformation and initiation. These studies will increase understanding of obesity-associated cancer risk and point to potential interventions to alleviate this risk or treat existing cancers.

PI_NAMEs: MAKOWSKI-HAYES, LIZA  (contact);PIERRE, JOSEPH F

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Acceleration;Address;African American population;Age;aged;Apoptosis;Area;bariatric surgery;Bile Acids;Biological Assay;black women;Body Weight decreased;Breast Cancer Cell;Breast Cancer Model;cancer cell;Cancer Etiology;cancer initiation;Cancer Patient;cancer risk;carcinogenicity;Carcinogens;cell transformation;Cells;Centenarian;Chronic;Coculture Techniques;Cytometry;Data;design;Diet;Dietary Administration;Dietary Supplementation;DNA;DNA Damage;Etiology;Exposure to;Failure;Funding;Genomic Instability;Goals;gut microbes;healthy weight;Heterogeneity;High Fat Diet;Human;human subject;Immune;Immunity;Immunotherapy;improved;In Vitro;Incidence;Inflammation;Inflammatory;innovation;Intervention;Intervention Studies;Investigation;Knowledge;Lead;Life Style;Link;Lithocholic Acid;Longevity;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mediating;Mediator;Metabolic;Metabolic dysfunction;metabolomics;Metagenomics;Microbe;microbial;microbiome;Minority;Mission;Modeling;mouse model;Mouse Strains;Mus;Obese Mice;obese patients;obese person;Obesity;Obesity associated cancer;obesogenic;Observational Study;Outcome;Outcome Measure;oxidative damage;Pathway interactions;Patient-Focused Outcomes;Patients;Phenotype;Population;Population Heterogeneity;Pre-Clinical Model;Predisposition;premalignant;preventive intervention;programs;Publishing;Qualifying;Race;Reactive Oxygen Species;Research;response;Risk;Risk Assessment;Risk Management;risk mitigation;Signal Transduction;single-cell RNA sequencing;Study models;T-Lymphocyte;Testing;Therapeutic;therapy outcome;Thinness;Transgenic Model;Translating;tumor;White Women;Woman;women subjects

PROJECT_TITLE: Determining the contribution of microbial-derived metabolites to protective immunity in obesity-driven cancer risk.


ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative RAS genes are mutated in human cancer more frequently than any other and the proteins they encode require association with cellular membranes to function. Over the past two decades we have studied the mechanisms that allow RAS to associate with membranes and now propose to build on this work to identify vulnerabilities that can be exploited in the development of novel anti-cancer therapies.

PI_NAMEs: PHILIPS, MARK REID (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Address;Biochemistry;Biological Assay;Biology;cancer genomics;cancer therapy;Cell membrane;cell transformation;Cells;Cellular Membrane;Clinic;CRISPR screen;Development;Enzymes;Farnesyl Transferase Inhibitor;farnesylation;Funding;Genes;Genetic Engineering;Genome;genome-wide;Glycolysis;hexokinase;Human;Image;innovation;insight;KRAS2 gene;Laboratories;Malignant Neoplasms;Mediating;Melanoma;Membrane;metabolomics;Methylation;Modification;Monomeric GTP-Binding Proteins;multidisciplinary;mutant;Mutate;Nature;novel;novel therapeutics;Oncogenes;Oncogenic;palmitoylation;Phosphorylation;Phosphotransferases;Post-Translational Protein Processing;Protein Isoforms;Protein Kinase;Proteins;Proteolysis;RAS genes;ras Proteins;recruit;Regulation;RNA interference screen;RNA Splicing;Rodent;Signal Transduction;structural biology;superresolution microscopy;Therapeutic;trafficking;transcriptomics;tumor;tumor metabolism;Variant;Work

PROJECT_TITLE: Differential function and tumor vulnerabilities revealed by RAS membrane trafficking


ORG_CITY: Waltham

ORG_NAME: LASE INNOVATION INC.

PHR: Narrative This project aims to foster fundamental discoveries and innovative research for the improvement of immunotherapies to treat cancer by harnessing the patients’ own immune cells. A major technological limitation is the lack of methods to characterize immune cells over time at high- throughput. The proposed research to develop novel time-lapse flow cytometry addresses this limitation, accelerating immunology and immune-oncology research and development.

PI_NAMEs: KWOK, SHELDON J.J. (contact)

PROGRAM_OFFICER_NAME: LOU, XING-JIAN

PROJECT_TERMS: Acceleration;Address;Adoptive Cell Transfers;Aliquot;Antibodies;Bar Codes;Biological Assay;Biological Markers;cancer cell;cancer immunotherapy;Cancer Patient;Cancer Vaccines;Cell Physiology;Cell Separation;Cell surface;Cells;cellular imaging;Chemicals;Chronic;Collaborations;commercialization;Contractor;cytokine;Data;Detection;Development;Enzyme-Linked Immunosorbent Assay;exhaustion;Exhibits;Flow Cytometry;Fostering;Goals;Hour;Human;Immune;immune checkpoint blockade;Immunologics;Immunooncology;Immunotherapy;improved;in vitro Assay;Individual;individualized medicine;innovation;instrumentation;Interferon Type II;Interleukin-10;Interleukin-2;Kinetics;laboratory development;Lasers;Malignant Neoplasms;Marketing;Measurement;Measures;Methods;Monitor;novel;particle;Patients;Performance;Peripheral Blood Mononuclear Cell;Phase;Phenotype;phenotypic biomarker;Prediction of Response to Therapy;Process;Production;programmed cell death protein 1;Protocols documentation;Quality Control;Reporting;Research;research and development;Research Personnel;Resistance;Resolution;response;Sampling;Scientist;Small Business Innovation Research Grant;Specificity;Standardization;Stimulus;systemic toxicity;T cell response;T-Lymphocyte;Technology;Time;TNF gene;Treatment outcome;Treatment Protocols;vaccine development;Validation

PROJECT_TITLE: Time-lapse Flow Cytometry for Kinetic Profiling of T-Cell Function


NIH_SPENDING_CATS: Pediatric

PHR: Program Narrative The Memphis STEM-M Ecosystem Scientists Communicate Research to Students (MemSCoReS) Program couples science communication professional development with high school outreach in the form of a virtual science journal club. The MemSCoReS program aligns well with the aim of the NIGMS Science Education Partnership Award (SEPA) program to “enhance the training of a workforce to meet the nation’s biomedical, behavioral and clinical research needs and especially of students from underserved communities” as it will work to enhance the science communication skills of the current workforce while also increasing STEM interest and identity development in the workforce of tomorrow. To do this, the program will develop, implement, and evaluate 1) the MemSTEMMbassadors Program, a professional development opportunity to enhance scientists’ science communication skills, 2) the Virtual Science Journal Club, a scientist/classroom partnership to expose high school students to scientists and primary literature, and 3) the Primary Scientific Literature in the Science Classroom Teacher’s Guide, a guide to provide teachers with structures to help integrate primary literature into their science classroom.

PI_NAMEs: AYERS, KATHERINE  (contact);MONTAGUE, SHELBY A.;SABEL, JAIME L

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Address;Area;Award;Behavioral Research;Biomedical Research;Black, Indigenous, People of Color;career;Career Choice;Clinical Research;Collaborations;Communication;Couples;Critical Thinking;Development;Ecosystem;Educational Curriculum;Educational process of instructing;Educational workshop;effectiveness evaluation;Evaluation;Exposure to;falls;Feedback;Feeling;Female;High School Faculty;High School Outreach;High School Student;improved;inequitable distribution;interest;journal article;Journals;Learning;Literature;Motivation;National Institute of General Medical Sciences;Nature;Persons;programs;racial disparity;Racial Segregation;Reporting;Research;Resources;Science;science education;science teacher;Science, Technology, Engineering and Mathematics Education;Scientist;Series;skills;Structure;student participation;Students;Suggestion;teacher;tool;Training;Training Activity;underserved community;underserved students;United States National Institutes of Health;virtual;Visit;Work;Writing;Youth

PROJECT_TITLE: Memphis STEM-M Ambassadors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: Project Narrative Diagnostic error remains one of the most prevalent forms of preventable error and one strategy to address this requires a multipronged approach to improve provider access to, and processing of, clinical information. The Electronic Health Records (EHR) is the main source of clinical information, with poor EHR use and design being key contributors to diagnostic error, although the ability to understand how, when and why the EHR contributes to diagnostic error to create effective solutions is severely limited by the lack of standardized tools for collecting this information. The goal for our Diagnostic Center of Excellence, DATAEYES, is to establish an infrastructure to systematically collect data on how, when and why the EHR contributes to diagnostic error and use this information to create a series of interventions aimed to address lacunae in training, software and workflow to standardize, and optimize EHR use to achieve diagnostic excellence.

PI_NAMEs: BATES, DAVID W., MD,MSC;GOLD, JEFFREY A. (contact);RATWANI, RAJ M

PROGRAM_OFFICER_NAME: COSBY, KAREN

PROJECT_TITLE: Diagnostic Accuracy through Advancing  EHR displaY,  Education and Surveillance (DATA-EYES)


ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: NARRATIVE The colon is an organ critical for human survival and has its own system of neurons, electrically coupled cells, and smooth muscle that work together to regulate its major function: motility for expulsion of waste. The goal of this project is to determine how these cells communicate to generate rhythmic colon motility and what goes wrong in conditions of dysmotility. Experimental data will be collected to produce a predictive, computational model that will allow investigators to use symptoms of different colon diseases to determine which cell types are compromised and guide the most effective treatments for restoration of function.

PI_NAMEs: SMITH-EDWARDS, KRISTEN MICHELLE (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: absorption;Address;Affect;Afferent Neurons;Anus;Behavior;Calcium;Cell Communication;Cell model;cell type;Cells;Colon;Colonic Diseases;Colonic inflammation;Complex;Computer Models;Coupled;Data;Devices;Distal;effective therapy;Ensure;Enteric Nervous System;Frequencies;Functional disorder;Gastrointestinal Motility;Goals;Health;Human;Image;imaging approach;Immunofluorescence Immunologic;in silico;In Situ;Individual;Inflammation;Interstitial Cell of Cajal;Knowledge;Length;Measures;Mechanics;Migrating Myoelectric Complex;Modeling;Motility;motility disorder;Motor;Motor Neurons;Movement;Mus;Muscle Tonus;Nerve;neural;neurochemistry;Neuromechanics;Neurons;neuroregulation;novel;novel therapeutics;optogenetics;Oral;Organ;Organism;Pacemakers;Pattern;Periodicity;programs;Property;Relaxation;Research Personnel;restoration;sensory input;Smooth Muscle;Stimulus;Stretching;Symptoms;System;Technology;Testing;Therapeutic;wasting;Work

PROJECT_TITLE: Defining and modeling the cellular interactions for rhythmic colon motility

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE A malignant pleural effusion (MPE) is an abnormal fluid collection between the lung and chest wall containing cancer cells that often develops in patients with advanced cancers. We hypothesize that cell-free DNA (cfDNA) within the supernatant fraction of an MPE represents an abundant, accessible, and efficient source of nucleic acids for downstream molecular testing. The goal of our project is to use our CLIA/CAP certified pan-cancer gene panel to optimize and define best practices for pre-analytical processing of cfDNA from MPE for clinical molecular testing.

PI_NAMEs: DEVINE, WALTER PATRICK (contact);KHANAFSHAR, ELHAM ;VAN ZIFFLE, JESSICA

PROGRAM_OFFICER_NAME: AGRAWAL, LOKESH

PROJECT_TERMS: Advanced Malignant Neoplasm;Affect;Ancillary Study;Area;Benchmarking;Benign;Biological Assay;Biopsy;Blood Tests;cancer cell;cell free DNA;Cell Separation;Cells;Centrifugation;Certification;Chemistry;Chest wall structure;Clinical;clinical practice;Collection;Cytology;Cytopathology;Data;detection test;Diagnosis;Diagnostic;DNA;Evaluation;Experimental Designs;experimental study;Formalin;Gene Frequency;gene panel;Gene Rearrangement;Genes;genetic testing;Goals;Guidelines;Hematoxylin and Eosin Staining Method;improved;Inflammatory;insertion/deletion mutation;Laboratories;Libraries;liquid biopsy;Liquid substance;Literature;Lung;Malignant Neoplasms;Malignant Pleural Effusion;Measures;Microsatellite Instability;Molecular;Molecular Analysis;molecular pathology;multidisciplinary;mutant;Mutation;neoplastic cell;next generation sequencing;Nucleic Acids;Oncogenes;Oncogenic;Paraffin Embedding;Pathologic;Pathologist;Patients;Plasma;Pleural;Pleural effusion disorder;Positioning Attribute;Preparation;Procedures;Process;Protocols documentation;Publishing;reduce symptoms;Reproducibility;Research;research clinical testing;Sampling;Serum;Slide;Source;Specimen;Speed;Stains;success;Surface;Techniques;Temperature;Testing;theories;Therapeutic;Thoracentesis;Time;time interval;Tissues;tumor;tumor heterogeneity;Tumor Tissue;Urine;Validation;Variant

PROJECT_TITLE: Comprehensive Analysis of Best Practices for Clinical Testing of Malignant Pleural Effusion Specimens


NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative The goal of the Asynchronous Open Online Course Addressing Structural Racism and Discrimination to Reduce Disparities project is to provide nationwide training modules that focus on addressing and mitigating structural racism and discrimination. We will develop an online Structural Racism course and disseminate widely using our national learning and mentoring platform that would facilitate inclusive, accessible, and equitable environments that ultimately cater to the recruitment and persistence of individuals within the biomedical research space.

PI_NAMEs: JAVIER, DAMARIS ;SYED, TOUFEEQ AHMED (contact);VISHWANATHA, JAMBOOR K.

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Address;Biomedical Research;career;Certification;cognitive interview;Communities;Course Content;design;Development;Discipline;Discrimination;disparity reduction;dissemination strategy;Educational Curriculum;Ensure;Environment;Equity;evidence base;experience;Faculty;Feedback;flexibility;Funding;Goals;harassment;higher education;improved;Individual;Institution;intersectionality;Journals;Learning;Learning Module;Manuscripts;meetings;Mentors;Nature;Newsletter;online course;Online Systems;Outcome;outreach;Participant;Peer Review;Persons;pilot test;podcast;Population Heterogeneity;Professional Organizations;Publications;recruit;Research;Research Training;Scholarship;social media;Structural Racism;Students;symposium;Techniques;Technology;Training;Training Activity;training opportunity;Training Programs;Training Support;Underrepresented Minority;United States National Institutes of Health;user-friendly;virtual;web site;webinar


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Immunotherapy;Liver Disease;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Interactions between malignant epithelial cells and cancer associated fibroblasts (CAF) are key determinants of pancreatic ductal adenocarcinoma (PDAC) growth, metastatic spread, and therapy resistance. However, CAF can either restrict or stimulate PDAC growth and CAF targeting therapies had failed in the clinic. Our project will focus on CAF-produced type I collagen, its cleavage and receptors that sense the balance between intact and cleaved collagens as novel approaches for converting CAF-mediated tumor promotion and immunosuppression to tumor growth inhibition and enhanced anti-tumor immunity.

PI_NAMEs: KARIN, MICHAEL  (contact);LOWY, ANDREW M;SCHWABE, ROBERT F.

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: antitumor effect;Carcinoma;Cell Communication;Cell Death Induction;Cells;Clinic;Clinical;Clinical Research;clinical translation;Coculture Techniques;Collagen;Collagen Fiber;Collagen Receptors;Collagen Type I;Complex;Data;DDR1 gene;Deposition;Desmoplastic;Environment;Equilibrium;Excision;Extracellular Matrix;Extracellular Matrix Proteins;Failure;Fiber;Fibroblasts;Goals;Growth;Human;Immune;immune activation;immune cell infiltrate;immune checkpoint blockade;Immune checkpoint inhibitor;immune clearance;Immunity;Immunologic Surveillance;Immunosuppression;improved;indexing;individualized medicine;Length;Ligands;Liver;Malignant - descriptor;Malignant Epithelial Cell;Malignant neoplasm of liver;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Mediator;Metabolic;Metabolism;Metastatic Neoplasm to the Liver;mouse model;Mus;Neoplasm Metastasis;novel;novel strategies;novel therapeutics;Nutrient availability;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Patients;Physical Restraint;Progression-Free Survivals;rational design;receptor;Receptor Signaling;refractory cancer;Regulation;Research;Resistance;Resolution;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;Slice;Specimen;Starvation;synergism;targeted treatment;Testing;Therapeutic Intervention;therapy development;therapy resistant;tool;trait;transcriptomics;translational scientist;tumor;tumor growth;Tumor Immunity;tumor metabolism;Tumor Promotion;Tumor Suppression;Vascular blood supply;Visceral metastasis

PROJECT_TITLE: Regulation of PDAC metabolism and immunity by collagen and its cleavage products


ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: NARRATIVE We are applying for funding to support students in a new interdepartmental Clinical Translational Research Certificate of Added Qualification Training Program that will offer unique translational research training to students selected from all graduate programs. The program will integrate with primary biomedical sciences PhD graduate programs, to which it will add a unique education in clinical translational research through a rigorous two-year curriculum with formal course work, practical skill building workshops, dedicated seminars, and experience in clinical research that integrates with the translational thesis research accepted students are performing. The ultimate goal of this program is to educate a highly skilled translational molecular medicine workforce, poised to become future research leaders who can efficiently navigate between bench and bedside to translate molecular discoveries from the lab to the clinic or develop molecular research strategies at the bench for solving important human health problems.

PI_NAMEs: MYSOREKAR, INDIRA U;VAN DEN VEYVER, IGNATIA B (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TITLE: The Clinical Translational Research Certificate of Added Qualification Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: STANFORD

ORG_DEPT: DERMATOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: EPIDERMAL SIGNALING REGULATORS  Project Narrative The normal control of tissue growth and differentiation is disrupted in human diseases. Increased knowledge of the signaling and genome regulators that mediate this process is designed to provide information to advance human health for skin and other tissues. 1

PI_NAMEs: KHAVARI, PAUL  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Adhesions;Biological;Cells;Chromatin;chromatin remodeling;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Cytoplasmic Tail;Data;design;Differentiated Gene;Disease;DNA;DNA Binding;DNA Methylation;DNA Sequence;Enhancers;Epidermis;epigenomics;extracellular;Family;FDA approved;FLRT3 gene;Funding;G-Protein-Coupled Receptors;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic approach;Genome;Genomic approach;Genomics;Growth;GTP-Binding Proteins;GTPase-Activating Proteins;Guanine Nucleotide Exchange Factors;Health;histone modification;Histones;Homeostasis;Human;human disease;insight;Integral Membrane Protein;ISWI;keratinocyte;keratinocyte differentiation;Knock-out;Knowledge;Malignant Neoplasms;Mammals;Mediating;member;Modeling;Molecular;Mutation;Pathogenicity;Pharmaceutical Preparations;Phosphoric Monoester Hydrolases;Physical activity;Process;progenitor;promoter;Protein Subunits;Proteins;Proteomics;RAPGEF2 gene;receptor;Regulation;Repression;Role;Signal Transduction;Signaling Protein;Site;Skin;Subgroup;Testing;Tissue Differentiation;Tissues;transcription factor;transcriptome sequencing;Translating;Transmembrane Domain;Undifferentiated;Visceral

PROJECT_TITLE: Epidermal Signaling Regulators

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE  As the only NCI-designated Cancer Center in Kentucky, the University of Kentucky Markey Cancer Center serves a statewide catchment area with a population of 4.4 million residents and extraordinary cancer prevalence. In its mission to reduce the cancer burden with a focus on Kentucky and its most vulnerable populations through research, prevention, treatment, education and community engagement, the center has made and will continue to make significant strides in advancing access to quality cancer care; implementing bold transformational research spanning basic, translational, and population science, including clinical trials to address Kentucky’s unique cancer burden; and introducing innovative population-level interventions to accelerate translational impact in reducing challenging health disparities and significantly impact patients in the state and the nation.

PI_NAMEs: EVERS, BERNARD MARK (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TERMS: Acceleration;Achievement;acronyms;Address;anti-cancer research;Appalachian Region;Award;Basic Science;Behavioral;Bioinformatics;Biometry;burden of illness;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer education;cancer genomics;cancer health disparity;Cancer Patient;cancer prevention;cancer risk;cancer site;cancer survival;career;Catchment Area;cellular oncology;Centers of Research Excellence;Climate;Clinical;clinical practice;Clinical Research;clinical translation;Clinical Trials;Clinical Trials Network;Collaborations;community engagement;community organizations;Community Outreach;Comprehensive Cancer Center;Death Rate;Development;Devices;Education;Education and Outreach;Epigenetic Process;equity, diversity, and inclusion;expectation;Faculty Recruitment;Flow Cytometry;Foundations;Funding;Genetic;Geography;Goals;Grant;health disparity;health equity;Immunologic Monitoring;improved;in vivo;Incidence;Informatics;Infrastructure;innovation;Institution;instrumentation;interdisciplinary collaboration;International;Intervention;Intervention Studies;Intervention Trial;Investigational Therapies;investigator-initiated trial;Investments;Kentucky;Leadership;Legal patent;Link;Malignant Neoplasms;Mediator;member;Mentors;Metabolic;Metabolism;Methods;Mission;Molecular;molecular oncology;mortality;National Cancer Institute;NCI Center for Cancer Research;Needs Assessment;neoplasm registry;next generation;novel therapeutics;Oncology;Outcome;Oxidation-Reduction;Paper;Participant;Pathology;patient oriented;Patients;Peer Review;personalized diagnostics;personalized therapeutic;Phase;Policies;Population;Population Sciences;Positioning Attribute;precision medicine;Preclinical Testing;Prevalence;Prevention;Program Development;programs;Publications;Publishing;Quality of life;recruit;Research;Research Personnel;Resource Sharing;Resources;Risk Factors;Rural;Rural Appalachia;Science;Scientist;SEER Program;Series;Services;Shapes;Signal Transduction;social;Strategic Planning;Students;Textiles;Therapeutic Clinical Trial;Therapeutic Trials;Training;Training and Education;Training Programs;Translating;translational impact;translational oncology;translational pipeline;Translational Research;treatment response;tumor;Underserved Population;Universities;Validation;Vision;Vulnerable Populations;Work;Workforce Development;Youth

PROJECT_TITLE: University of Kentucky Markey Cancer Center – Cancer Center Support Grant