ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative Visual crowding, the inability to identify stimuli amidst clutter, impairs object recognition performance in peripheral vision. Crowding is particularly detrimental in patients with central vision loss such as Macular Degeneration, since these individuals rely exclusively on their peripheral vision for object recognition tasks. In this proposal we will investigate the neural bases of crowding in the visual system of the non-human primate, to inform possible future intervention studies in central vision loss.

PI_NAMEs: NANDY, ANIRVAN S. (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Address;Affect;Animals;Area;area V4;Attention;awake;base;Blindness;Cells;Chronic;Clutterings;Crowding;density;excitatory neuron;extrastriate visual cortex;fovea centralis;Future;gaze;Impairment;Individual;inhibitory neuron;interest;Intervention Studies;Investigation;Knowledge;Location;Macular degeneration;Maps;Mediating;Nature;neural;neural correlate;neuromechanism;Neurons;nonhuman primate;novel;object recognition;oculomotor;Output;Pathway interactions;Patients;Perception;Performance;Peripheral;Photic Stimulation;Process;Protocols documentation;Radial;receptive field;Research;Resources;Retina;Saccades;Scotoma;Sensory;Shapes;Signal Transduction;Site;spatiotemporal;Stimulus;Target Populations;Testing;Time;Vision;Visual;Visual Perception;Visual System

PROJECT_TITLE: Neural Mechanisms of Visual Crowding

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Lung;Neurosciences

ORG_CITY: COLUMBIA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: VETERINARY SCIENCES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: NARRATIVE Many cardiorespiratory diseases manifest as unstable breathing and episodic periods of hypoxia resulting in sympathetic-mediated hypertension; an exaggerated chemoreflex and its brain interaction are implicated in these responses. Our studies will determine the importance of altered GABA-mediated inhibition in sensory and brainstem reflex neurons in an episodic hypoxia rat model. We expect to define how targeting these brain mechanisms can be used to design rational and novel therapeutic approaches to the consequences of hypoxia.

PI_NAMEs: KLINE, DAVID DOUGLAS (contact)

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: Address;Animal Model;Animals;Astrocytes;Attenuated;Brain;Brain Stem;Breathing;Cardiovascular system;Carotid Body;Cell Nucleus;Cells;Chlorides;Chronic;Data;Dependovirus;designer receptors exclusively activated by designer drugs;Disease;Electrophysiology (science);Epilepsy;Equilibrium;Exhibits;Exposure to;falls;Familial Dysautonomia;Foundations;gamma-Aminobutyric Acid;Glutamate Transporter;glutamatergic signaling;Glutamates;Goals;Homeostasis;Hypertension;Hypoxia;Investigation;Knowledge;Literature;live cell imaging;Mediating;Modeling;Molecular Biology;Morbidity - disease rate;mortality;Neurons;normoxia;novel therapeutic intervention;Nucleus solitarius;Obstructive Sleep Apnea;Pathway interactions;Patients;Peripheral;Physiological;Process;Rat Transgene;rational design;Rattus;receptor;Receptor Activation;Reflex action;Research;respiratory;response;Rett Syndrome;reuptake;Sensory;sensory integration;Signal Transduction;Site;symporter;Synapses;System;Techniques;Technology;uptake

PROJECT_TITLE: GABA signaling in the nTS and cardiorespiratory responses to hypoxia

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases

ORG_CITY: ATHENS

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Health Relevance  Invasive fungal infections in immune compromised patients cause millions of deaths each year and are refractory to antifungal drug treatment with exceedingly high mortality rates. We developed paradigm-changing antifungal delivery system in which drug-loaded liposomes are targeted to specifically to fungal cells and their exopolysaccharide matrices. Targeted liposomes have order of magnitude enhanced antifungal activity toward Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans. We plan to show increased therapeutic efficiency toward candidiasis, aspergillosis, cryptococcosis and mucormycosis in mouse models.

PI_NAMEs: LEWIS, ZACHARY ;MEAGHER, RICHARD BRIAN (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affinity;Allergic Bronchopulmonary Aspergillosis;Amphotericin;Amphotericin B;Anidulafungin;anti-fungal agents;Antifungal Therapy;Area;Aspergillosis;Aspergillus fumigatus;Azoles;Binding;C Type Lectin Receptors;C-Type Lectins;cancer therapy;Candida albicans;Candida auris;Candidiasis;Carbohydrates;Cause of Death;Cell Wall;Cells;Cessation of life;chronic infection;Clinical;Cryptococcal Meningitis;Cryptococcosis;Cryptococcus neoformans;Custom;Data;Death Rate;dectin 1;design;Detergents;Devices;Direct Costs;Disease;disease model;Dose;Drug Controls;Drug Delivery Systems;drug efficacy;Drug Industry;Drug resistance;Drug Targeting;Endothelium;experience;experimental study;Fluconazole;Funding Mechanisms;Fungal eye infections;fungicide;fungus;Glucans;Goals;Health;high reward;high risk;HIV Seropositivity;Hospital Costs;Human;Immune;Immune system;immunosuppressed;improved;In Vitro;Individual;Infection;Inflammatory;Infusion procedures;innovation;innovative technologies;Life;Liposomes;Lung;Mannans;Medical Care Costs;Medical Device;member;Microbial Biofilms;Molds;mouse dectin-2;mouse model;Mucormycosis;Multiple Fungal Drug Resistance;Mycoses;novel therapeutics;Organ;Organ Transplantation;Outcome;pathogen;pathogenic fungus;patient population;Patients;Penetration;Performance;Pharmaceutical Preparations;Pharmacotherapy;Polyenes;pre-clinical;Pre-Clinical Model;Proteins;Protozoa;Refractory;Resistance;Rhizopus;Risk;Science;Scientist;Skin;Stem cell transplant;Structure of nail of toe;System;Systemic infection;targeted treatment;Technology;Testing;Therapeutic;therapeutically effective;Tissues;Toxic effect;Transplant Recipients;treatment duration;Treatment Failure;Treatment-related toxicity;Vulnerable Populations;Work;Yeasts

PROJECT_TITLE: Targeted Pan-Antifungal Liposomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-Q(83)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Arthritis;Osteoarthritis

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: The proposed research is relevant to public health because the newly gained knowledge of sex- specific OA progression may lead to development of so-called “senostatic” drugs as a novel approach to targeting patients for precision medical treatment. The re-purpose of the NRTIs for OA treatment is highly attractive because it will greatly shorten the length and expense of OA drug development. Thus, the proposed research is relevant to the part of NIH's mission that translating scientific discovery into health that will help to reduce the burdens of human disability.

PI_NAMEs: CHEN, QIAN  (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Address;Aging;aging related;Anti-viral Agents;articular cartilage;Bone remodeling;Cartilage;cartilage degradation;Cell Aging;Cells;Chondrocytes;Chronic;Clinical;clinical practice;Code;Complex;Data;Degenerative polyarthritis;derepression;Development;disability;Disease;disease disparity;DNA Transposable Elements;drug development;early onset;effective therapy;effectiveness testing;Elderly;Elements;FDA approved;Female;Fibrosis;Genes;Goals;Health;Human;Inflammation;Injury;innovation;Interleukin-1 beta;Intervention;joint destruction;joint injury;Joints;Knee Osteoarthritis;Knowledge;Lamivudine;Length;Lesion;male;Medial meniscus structure;Medical;men;mesenchymal stromal cell;Mission;Molecular;mouse model;Mus;novel marker;novel strategies;Nuclear;nucleoside inhibitor;Nucleosides;Outcome;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;Phenotype;Population;precision medicine;Predisposition;Prevalence;Process;Public Health;Regulation;Repression;Research;Resistance;Retrotransposon;Reverse Transcriptase Inhibitors;Role;senescence;senescence associated secretory phenotype;senescent cell;senomorphic;Severities;sex;Sex Differences;Signal Transduction;Sterility;Stress;Testing;transcriptome sequencing;transcriptomics;Translating;Traumatic Arthropathy;United States National Institutes of Health;Woman;women patients

PROJECT_TITLE: Cell Senescence Regulating Osteoarthritis Progression: Sex-dependent Mechanisms

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Rett Syndrome;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Brain organoids are emerging as powerful tools for studying the mechanisms behind human brain development and disease. In our recent studies, we developed a platform for assembling functional neural circuits that exhibit surprisingly complex neural network activities such as oscillatory rhythms. In the proposed studies, we will explore how brain organoids can be best utilized to discover the mechanisms behind a range of neurological disorders and develop strategies for therapeutic development.

PI_NAMEs: NOVITCH, BENNETT G (contact)

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: Address;Anatomy;Anticonvulsants;Appearance;Brain;Brain region;Calcium;Cells;clinical phenotype;Complex;Coupling;Culture Techniques;Defect;Development;Disease;disease model;DNA Sequence Alteration;Electrophysiology (science);epileptic encephalopathies;epileptiform;excitatory neuron;Exhibits;experimental study;Frequencies;Functional disorder;Gene Mutation;Genes;global health;Goals;Growth;High Frequency Oscillation;Human;human embryonic stem cell;Image;induced pluripotent stem cell;inhibitory neuron;Link;lissencephaly;Methods;Methyl-CpG-Binding Protein 2;Microcephaly;Modeling;Molecular;mosaic;Mosaicism;Mutation;Nature;Nervous System Disorder;Nervous System Physiology;network dysfunction;neural;neural circuit;neural network;Neurodevelopmental Disorder;Neurologic;Neuronal Dysfunction;Neurons;neuropathology;Neurophysiology - biologic function;neuropsychiatric disorder;neuroregulation;novel therapeutics;Organoids;pathogen;Pathologic;Pathology;Pathway interactions;Patients;Phenotype;Population;preservation;protein function;Reporting;Rett Syndrome;Sampling;SCN8A gene;Seizures;sensor;Severities;Slice;stem;stem cell model;Structural defect;Structure;Symptoms;Syndrome;System;Testing;Therapeutic;therapeutic development;tool;Variant;Work;X Chromosome;Zika Virus

PROJECT_TITLE: Elucidating the molecular mechanisms behind human neurodevelopmental disorders using brain organoids


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: CINCINNATI

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Without a substantial increase the pool of early stage physicians interested in embarking on a research career, the shortfall of successful physician scientists will continue to worsen. We propose to address this challenge by instituting a program, University of Cincinnati-StARR, that provides internal medicine residents interested in a research career with the research tools available at UC as well as Cincinnati Children’s (CCHMC) to then transition to academic fellowships and a successful physician scientist career. This will complement an infrastructure that is already in place at that has focused more on enhancing academic fellowship training.

PI_NAMEs: OTOOLE, JENNIFER ;RUBINSTEIN, JACK  (contact);SADAYAPPAN, SAKTHIVEL ;SCHAUER, DANIEL P

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: Academic Medical Centers;Accreditation;Address;Adult;American;Appointment;Basic Science;Cardiovascular system;career;Career Choice;Child;Childhood;Clinical Research;college;Competence;Complement;Complex;Coupling;Critical Care;Dedications;Development Plans;Discipline;Education;education research;Educational Curriculum;Educational Status;Educational workshop;Ensure;Evaluation;experience;Faculty;falls;Fellowship;flexibility;Funding;Future;Goals;graduate medical education;Grant;implementation science;Individual;Infrastructure;innovation;interest;Internal Medicine;Intervention;Investments;Junior Physician;Learning;Link;Lung;Manuscripts;Medical center;Medical Research;Medicine;Mentors;Modeling;National Heart, Lung, and Blood Institute;online course;Outcome;Pathway interactions;Pediatric Hospitals;physician-scientist training program;Physicians;Positioning Attribute;Process;Production;Program Description;programs;Publishing;Qualifying;recruit;Research;Research Personnel;Research Project Grants;Residencies;Scientist;Secure;Special needs;success;successful intervention;System;systematic review;Time;tool;Training;Translational Research;United States National Institutes of Health;Universities;Work;working group

PROJECT_TITLE: Stimulating Access to Research in the University of Cincinnati Internal Medicine Residency Program


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: Los Angeles

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: After a heart attack, there is a localized site of severe cardiac injury where the tissue experiences poor blood perfusion, low oxygen levels, and death of the beating cells of the heart. Restoration of blood flow is necessary but causes further damage to the heart, known as ischemia-reperfusion injury. By engineering organ-on-a-chip microdevices to model these cardiac injuries, better therapeutic strategies can be developed to minimize damage and promote repair.

PI_NAMEs: REXIUS, MEGAN L. (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Academia;Acute myocardial infarction;Address;Affect;Architecture;Area;Autophagocytosis;Binding;Bioinformatics;Biological Assay;Biomedical Engineering;Blood flow;blood perfusion;Calcium;California;Cardiac;Cardiac Myocytes;Cell Physiology;Cessation of life;Characteristics;Coenzymes;Communication;Complex;Coronary artery;coronary artery occlusion;Coupled;Data;Data Set;Dependence;Development;Engineering;Environment;exosome;experience;extracellular;Fluorescence Microscopy;Functional disorder;Goals;Heart;heart cell;Heart Injuries;Heterogeneity;Human;human induced pluripotent stem cells;Hypoxia;Image;In Vitro;in vitro Model;in vivo Model;Incubators;induced pluripotent stem cell derived cardiomyocytes;injured;Injury;innovation;insight;intercellular communication;Investigation;Ischemia;Laboratories;Lead;Los Angeles;Measurement;Measures;Mediating;Mediator;medical schools;Membrane Potentials;Mentors;Mentorship;Metabolic;metabolic imaging;Metabolism;Methods;microdevice;Microfluidic Microchips;Microfluidics;microphysiology system;MicroRNAs;mitochondrial membrane;Modeling;Molecular;Molecular Analysis;Monitor;Motion;multi-scale modeling;myocardial damage;Myocardial dysfunction;myocardial hypoxia;Myocardial Infarction;Myocardial Reperfusion Injury;Myocardial Stunning;Myocardial tissue;Myocardium;novel;optical imaging;Optics;organ on a chip;Oxygen;paracrine;Paracrine Communication;Pathologic Processes;Pathway interactions;Pediatric Hospitals;pharmacologic;Phase;Phenotype;Physiological;preservation;Process;programs;Proteomics;Reactive Oxygen Species;Recycling;Regulation;release of sequestered calcium ion into cytoplasm;repaired;Reperfusion Injury;Reperfusion Therapy;Research;Research Personnel;response;restoration;Role;Sarcomeres;Site;skills;spatiotemporal;System;Technology;Therapeutic;Therapeutic Effect;Time;Tissue Viability;Tissues;tool;Traction;Traction Force Microscopy;Training;Universities;Vascular blood supply

PROJECT_TITLE: Microphysiological Systems to Study Hypoxic Cardiac Injury

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(OA)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: PROJECT NARRATIVE This project is relevant to public health because it explains how light regulates the development of blood vessels in the eye. This work has implications for human health because it may provide a way to treat neonatal eye disease with light stimulation therapy.

PI_NAMEs: LANG, RICHARD A. (contact);XIN, MEI

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Basic Science;Biological Models;Biology;Birth;blood vessel development;Blood Vessels;Cell Survival;Cues;Data;Development;Dopamine;Dopamine Receptor;DRD2 gene;Educational process of instructing;Electrophysiology (science);Event;experimental study;Eye;Eye diseases;fetal;Genetic;Goals;Health;Human;interest;KDR gene;Knowledge;Light;Link;loss of function;Mediating;melanopsin;Methods;Mus;Neonatal;Neuromodulator;novel therapeutics;Opsin;overexpression;Oxygen;Pathway interactions;Play;Pregnancy;Production;Public Health;Publishing;Regulation;response;Retina;retinal neuron;Retinopathy of Prematurity;Role;Signal Transduction;Stimulus;Testing;Text;Therapeutic;Vascular Endothelial Cell;Vascular Endothelial Growth Factors;VEGFA gene;vessel regression;Viola;Visual System;Work

PROJECT_TITLE: Light regulated vascular development in the eye via the Hippo pathway

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Narrative We propose highly integrated and multidisciplinary mechanistic studies to investigate how activating mutations and post translational modifications in RAS and heterotrimeric guanine nucleotide binding proteins, regulate cell signaling and tumorigenesis. Results from these analyses will inform precision medicine approaches to antagonize deregulated G-protein signaling in cancer. We will also investigate how vinculin and metavinculin proteins individually and coordinately mediate actin cytoskeletal rearrangements and associate with the membrane, to elucidate how they regulate cell morphology, force transmission and cell motility. In addition, we will examine how deregulation of these cell adhesion proteins alters force transmission within the heart leading to cardiovascular disease.

PI_NAMEs: CAMPBELL, SHARON L (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Actins;Binding;Biochemical;Cardiomyopathies;Cardiovascular Diseases;Cell Adhesion Molecules;cell growth regulation;cell motility;Cellular biology;Cellular Morphology;Codon Nucleotides;Cytoskeleton;Defect;F-Actin;GTP-Binding Proteins;guanine nucleotide binding protein;Guanine Nucleotides;Heart;Heart Diseases;Individual;Investigation;Malignant Neoplasms;Mediating;Membrane;Modeling;multidisciplinary;Mutation;novel;Nucleotides;Oncogenic;Play;Post-Translational Protein Processing;precision medicine;protein activation;Protein Isoforms;protein structure;Proteins;Regulation;Role;Signal Transduction;Signaling Protein;Structure;transmission process;tumorigenesis;Vinculin;Work

PROJECT_TITLE: Structure and Mechanism of G-proteins and cell adhesion proteins in regulation of cell growth and motility

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Gram-negative bacteria (e.g., Escherichia coli) are responsible for a number of human infectious diseases. Much like armor, these bacteria have a unique outer surface that prevents the use of a number of antibiotics. This proposal will help determine the molecular machinery used by the Gram-negative bacterium Acinetobacter baumannii, an extensively drug-resistant bacterium causing devastating disease, to assemble its outer surface. Understanding how bacteria assemble their outer armor will allow for the development of novel therapies to fight multi-drug resistant infections.

PI_NAMEs: TRENT, MICHAEL STEPHEN (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acinetobacter baumannii;Address;Amines;Anabolism;analog;Antibiotic Resistance;Antibiotics;antimicrobial;Antimicrobial Cationic Peptides;Antimicrobial Resistance;Architecture;Bacteria;bacterial fitness;Bacterial Physiology;Biogenesis;Biology;Blood;cell envelope;Cell Maintenance;Cell Membrane Permeability;Cell surface;cell type;Cells;Cessation of life;Charge;Chemicals;Communicable Diseases;Complex;Core Assembly;Cytolysis;Data;Defect;Development;Disease;drug resistant bacteria;emerging pathogen;Encapsulated;Environment;Escherichia coli;Evolution;experimental study;extensive drug resistance;Extravasation;fighting;fitness;gene product;Genes;Genetic;Glycerophospholipids;Goals;Gram-Negative Bacteria;Gram-Negative Bacterial Infections;Growth;Human;Hydrophobicity;Hypersensitivity;Infection;inorganic phosphate;Lipid A;Lipid Binding;Lipids;lipooligosaccharide;lipophilicity;Lipopolysaccharide Biosynthesis Pathway;Lipopolysaccharides;Lipoproteins;Literature;Lung;Maintenance;Membrane;membrane assembly;membrane biogenesis;Membrane Lipids;Modification;Molecular;Multi-Drug Resistance;multi-drug resistant pathogen;Nosocomial Infections;novel;novel therapeutics;null mutation;O Antigens;Oligosaccharides;Operative Surgical Procedures;Organism;pathogen;Pathogenesis;Pathway interactions;Peptidoglycan;Pharmaceutical Preparations;Phospholipases A;Poison;Polymyxin Resistance;Polymyxins;prevent;priority pathogen;Process;protein transport;Proteins;Resistance;resistance mechanism;response;Role;Series;Structure;sugar;Surface;System;tool;transposon sequencing;Urinary tract infection;Virulence;World Health Organization;wound

PROJECT_TITLE: The Cell Envelope of the Multi-Drug Resistant Pathogen Acinetobacter baumannii

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-T(02)M]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Biomedical Imaging;Cancer;Chronic Pain;Clinical Research;Immunotherapy;Osteoarthritis;Pain Research;Prevention

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative This project addresses the relationship between immune checkpoint inhibitors, a type of cancer therapy, and osteoarthritis. The proposal will determine if osteoarthritis is a risk factor for immune checkpoint inhibitor- induced inflammatory arthritis. The proposal will also evaluate whether there is increased progression of osteoarthritis on imaging in patients treated with immune checkpoint inhibitor therapy.

PI_NAMEs: CAPPELLI, LAURA CHRISTINE (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: abdominal CT;Address;Advanced Malignant Neoplasm;Adverse effects;Affect;Age;Body mass index;Body System;Bone Marrow;Cancer Patient;Cancer Survivor;cancer therapy;cancer type;checkpoint therapy;Classification;Clinical;clinical care;Clinical Investigator;clinical risk;cohort;Cohort Studies;Collaborations;comorbidity;cost;CTLA4 gene;Data;Degenerative polyarthritis;Development;Edema;experience;Exposure to;Fostering;Foundations;Goals;hazard;Hip Osteoarthritis;Hip region structure;Image;Immune;immune activation;Immune checkpoint inhibitor;immune-related adverse events;Immunologic Factors;improved;improved outcome;Inflammation;Inflammatory Arthritis;joint injury;Joints;Long-Term Survivors;Longitudinal cohort;Malignant neoplasm of lung;Malignant Neoplasms;Melanoma;Methods;Modeling;Monitor;Morbidity - disease rate;Musculoskeletal;Oncology;Osteogenesis;Pain;patient stratification;Patients;Pelvis;Prevalence;Prevention strategy;Preventive therapy;Process;programmed cell death ligand 1;programmed cell death protein 1;prospective;Protocols documentation;Provider;Pulmonary Inflammation;Quality of life;Radiation exposure;radiological imaging;Radiology Specialty;Regression Analysis;Reporting;research clinical testing;rheumatologist;Risk;Risk Factors;risk stratification;screening;Severities;sex;skills;Staging;Standardization;Symptoms;Synovitis;System;systemic inflammatory response;T-Cell Activation;Testing;Time;Tissues;Translating;tumor;Vitiligo;X-Ray Computed Tomography

PROJECT_TITLE: Evaluating the relationship between immune checkpoint inhibitors and osteoarthritis

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Gene Therapy;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Project Narrative Cardiac arrest is the leading cause of death in the United States and other developed countries. In public discussions, these deaths are often called “heart attacks,” but in reality, they most often occur as a result of lethal ventricular arrhythmias. We previously identified unique elements of the electrical circuits that cause these ventricular arrhythmias. This proposal focuses on developing gene therapies to prevent these unique elements from supporting ventricular tachycardia, thereby eliminating these arrhythmias.

PI_NAMEs: DONAHUE, J KEVIN (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Abbreviations;Action Potentials;adeno-associated viral vector;Anatomy;Area;Arrhythmia;Atrial Fibrillation;Attenuated;Autopsy;Biodistribution;Cause of Death;Cell Physiology;Cessation of life;Cicatrix;clinical development;Complex;Connexin 43;Coronary Arteriosclerosis;Data;Dependovirus;Developed Countries;Disease;Ectopic beats;efficacy evaluation;Electrophysiology (science);Elements;Environment;Etiology;Event;experience;Fiber;Functional disorder;Future;Gap Junctions;Gene Delivery;gene therapy;gene therapy clinical trial;Gene Transfer;Genes;Goals;Green Fluorescent Proteins;healing;Heart Arrest;Heart Atrium;Heterogeneity;Impairment;Infarction;Intercalated disc;Intervention;Investigational New Drug Application;Left Ventricular Ejection Fraction;Malignant - descriptor;Methods;Monitor;Muscle Cells;Mutation;Myocardial;Myocardial Infarction;Myocardial tissue;novel;Paint;Patients;Pattern;Perfusion;Persons;Postoperative Period;Potassium Channel;pre-clinical;pre-clinical therapy;prevent;Program Development;Proteins;Refractory;Reporting;Research;research clinical testing;response;Role;Safety;Serious Adverse Event;sudden cardiac death;Sudden Death;Tachyarrhythmias;Testing;therapy development;Time;Tissues;transgene delivery;Transgenes;Translating;United States;Ventricular;Ventricular Arrhythmia;Ventricular Fibrillation;Ventricular Tachycardia;Work

PROJECT_TITLE: Translating post-infarct ventricular tachycardia mechanisms into a therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Kidney Disease;Lung;Pneumonia;Pneumonia and Influenza;Prevention;Vaccine Related

PHR: PROJECT NARRATIVE Influenza and pneumococcal infections occurring in individuals with glomerular disease are preventable contributors to excess healthcare utilization, morbidity, and mortality. Vaccination is a powerful and cost- effective method to attenuate infectious burden, however, vaccine immunogenicity and effectiveness have been under-studied in this high-risk population. The objective of this proposal is to describe influenza and pneumococcal vaccine effectiveness and immunogenicity in patients with glomerular disease.

PI_NAMEs: GLENN, DOREY  (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Acceleration;Address;Adult;Advisory Committees;Age;Antibiotics;Antibodies;Antibody titer measurement;Attenuated;Biological Assay;Biopsy;career;career development;Cause of Death;Cell Physiology;Characteristics;Child;Clinical;clinical practice;cohort;Communicable Diseases;Complement;cost effective;Data;Data Analyses;Databases;Development;Disease;Effectiveness;Epidemiology;epidemiology study;experience;Exposure to;Foundations;Frequencies;Goals;Guidelines;health care service utilization;Healthcare;high risk;high risk population;hospital care;IgG Deficiency;Immune;Immune response;Immunity;immunogenicity;Immunoglobulins;Immunosuppression;Impairment;in vivo;Incidence;Individual;Infection;Infection prevention;Influenza;influenza infection;influenza virus vaccine;Kidney Diseases;Lead;longitudinal analysis;longitudinal dataset;Lower Respiratory Tract Infection;Measurement;Measures;Mediating;Mentorship;Methods;Monitor;Morbidity - disease rate;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrotic Syndrome;Participant;patient population;Patients;Pharmaceutical Preparations;Pneumococcal Infections;Pneumococcal vaccine;Population;pragmatic trial;Preparation;Prevention Measures;Prevention strategy;Preventive measure;prophylactic;prospective;Prospective, cohort study;Proteinuria;Rare Diseases;Recommendation;Regimen;Renal function;Renal glomerular disease;Research;Research Design;Resources;Risk Factors;Sample Size;Scientist;seroconversion;Statistical Methods;Streptococcus pneumoniae;Testing;Time;Training;urinary;Vaccinated;Vaccination;vaccination strategy;vaccine effectiveness;vaccine immunogenicity;vaccine response;Vaccines;Work

PROJECT_TITLE: Protecting Patients with Glomerular Disease from Vaccine-Preventable Infections

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The coronavirus disease pandemic has led to rapid expansion of telemedicine services. Our study is focused on evaluating the impact of telemedicine adoption on ambulatory care for Medicare beneficiaries with three specific aims: (1) to identify provider- and market-level determinants of telemedicine use in the Medicare population, (2) to evaluate the association between practice-level telemedicine use and the rate of hospital admissions for ambulatory care sensitive conditions and (3) to evaluate the impact of clinician-level telemedicine use on Medicare spending and utilization. The proposed research will identify policy targets that can be used by policymakers and healthcare organizations to ensure the equitable, efficient, and effective expansion of telemedicine services.

PI_NAMEs: ELLIMOOTTIL, CHANDY SKARIA;THOMPSON, MICHAEL PATRICK (contact)

PROGRAM_OFFICER_NAME: ZHANG, XINZHI

PROJECT_TITLE: Evaluating the Impact of Telemedicine on Ambulatory Care

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: JACKSON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: PROJECT NARRATIVE Cardiovascular diseases are the leading causes of mortality and morbidity in the United States and worldwide. Current therapies for heart failure after myocardial infarction offer only limited benefit and new, more effective treatments that can slow/halt disease progression and improve heart function are desperately needed. The primary focus of this proposal is to test a novel therapeutic approach for preventing progression of heart failure after myocardial infarction by activating brain melanocortin 4 receptors and to unravel the molecular/cellular mechanisms involved.

PI_NAMEs: DO CARMO, JUSSARA M.;SILVA, ALEXANDRE ALVES DA (contact)

PROJECT_TERMS: Agonist;American;Animal Model;Animals;Anterior Descending Coronary Artery;Aorta;Area;Back;Biogenesis;Blood;Blood - brain barrier anatomy;blood-brain barrier crossing;Brain;Brain Stem;Bypass;Cardiac;Cardiac Myocytes;Cardiac Output;cardioprotection;Cardiovascular Diseases;Cardiovascular system;Cell Nucleus;Central Nervous System;Cerebral Ventricles;cholinergic neuron;Chronic;Congestive Heart Failure;Data;Death Rate;Diameter;Disease Progression;dorsal motor nucleus;Dose;Echocardiography;effective therapy;EFRAC;Energy Metabolism;exercise capacity;fatty acid oxidation;Genetic;Genetic Engineering;Glucose;healthcare burden;Heart;Heart failure;heart function;heart preservation;Human;Hypothalamic structure;Imaging Techniques;Imaging technology;improved;In Vitro;in vivo;Infusion procedures;innovation;Knock-out;Lateral;Left;Left atrial structure;Left ventricular structure;Leptin;Leptin resistance;Ligation;Measurement;Measures;Mediating;Melanocortin 4 Receptor;melanotan-II;Metabolic;Metabolic stress;Mitochondria;Molecular;Morbidity - disease rate;Morphology;mortality;Mus;Muscle function;Muscle strain;Myocardial dysfunction;Myocardial Infarction;Myocardium;novel;novel therapeutic intervention;obese patients;Obesity;obesity genetics;Outcome Study;oxidation;paraventricular nucleus;Pathway interactions;Patients;Peripheral;Preparation;prevent;Production;protective effect;Protocols documentation;Rattus;Receptor Activation;Resistance;Resolution;Risk;Risk Factors;Sirtuins;success;System;Testing;therapeutically effective;Thinness;ultrasound;United States

PROJECT_TITLE: Cardiac protective mechanisms of melanocortin system activation


PHR: PROJECT NARRATIVE Cryptococcal meningoencephalitis poses a serious threat to public health, causing more than 180,000 deaths from about 225,000 infections each year. Given the poor outcome of the current antifungal therapies to treat cryptococcosis and the lack of vaccines to prevent this deadly disease, it is urgent and critical to develop effective vaccines for high risk patients. Findings from the proposed research will likely provide a successful platform for mRNA vaccine development against cryptococcosis and other deadly fungal diseases.

PI_NAMEs: LIN, XIAORONG  (contact);MEAGHER, RICHARD BRIAN

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Actins;Animal Model;Animals;anti-fungal agents;Antibody Formation;Antibody titer measurement;Antifungal Therapy;Antigens;aqueous;Bacterial Infections;Biochemical;Biology;Brain;Cell Culture Techniques;Cell surface;Cells;Central Nervous System Fungal Infections;Central Nervous System Infections;Cessation of life;Chemistry;Clinical;Clinical Trials;Code;combat;combinatorial;Communities;Complex;cost;COVID-19 vaccine;Cryptococcosis;Cryptococcus;Cryptococcus gattii;Cryptococcus neoformans;Cytoplasm;Data;Death Rate;design;Diagnosis;Disease;Drug Delivery Systems;efficacy evaluation;Encapsulated;Endoplasmic Reticulum;Ensure;Escherichia coli;Ethics;experience;Exploratory/Developmental Grant;extracellular;Extracellular Protein;fighting;fungus;Future;Genetic;glycation;glycosylation;Goals;Grant;high risk;HIV;Human;Immune response;Immunocompetent;Immunocompromised Host;immunogenicity;Immunology;Immunosuppression;In Vitro;in vivo;Individual;Infection;Injections;Life;lipid nanoparticle;Lipids;Liposomes;Mammalian Cell;Measures;Meningoencephalitis;Messenger RNA;Microfluidics;Molecular;Monkeys;mouse model;mRNA lipid nano particle vaccine;Mus;mutant;Mycoses;nanoparticle;nanoparticle delivery;Nature;novel;Nucleic Acids;Organ;Organic solvent product;Outcome;Pathogenesis;pathogenic fungus;Patients;plasmid DNA;Poly(A) Tail;preclinical study;prevent;Productivity;protective effect;Protein Subunits;Proteins;Public Health;Recombinant Proteins;red fluorescent protein;Research;Research Personnel;RNA vaccine;Role;Safety;Serum;Solvents;Stains;Subunit Vaccines;Technology;Testing;Therapeutic;Therapeutic immunosuppression;Time;Transcript;Translating;Translations;Untranslated Regions;Vaccinated;Vaccination;vaccine access;vaccine candidate;vaccine delivery;Vaccine Design;vaccine development;vaccine efficacy;vaccine evaluation;Vaccine Production;vaccine strategy;Vaccines;Viral;Virus;Whole Cell Vaccine;Work

PROJECT_TITLE: Develop and Assess mRNA Lipid Nanoparticle Vaccines Against Cryptococcosis

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Lead Poisoning;Neurodegenerative;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE Environmental exposures are related to risk of Alzheimer’s disease and related dementias. To achieve unparalleled understanding of brain composition, biology, and response to early life exposure to lead (Pb), the goal of this study is to identify sex-specific consequences of perinatal lead exposure in the mouse brain by pathology, DNA methylation, hydroxymethylation, and RNA expression, including measures at the single cell level. Results from these experiments will advance our understanding of how early life lead exposures affect the later life brain, with potential lifelong impacts on Alzheimer’s disease and related dementias.

PI_NAMEs: BAKULSKI, KELLY  (contact);COLACINO, JUSTIN ADAM

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: Adult;advanced disease;Affect;Age;Age Months;Alzheimer's Disease;Alzheimer's Disease Pathway;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Autopsy;Behavior;Biological;Biological Assay;Biology;Blood;Brain;brain cell;brain morphology;Brain Pathology;Brain region;cell type;Cells;Cerebellum;Chromatin;Complex;Data;Dementia;Development;Developmental Biology;dietary control;Disease;disorder prevention;DNA;DNA Methylation;early life exposure;emerging adult;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiology;epidemiology study;Epigenetic Process;epigenome;Ethnic Origin;Evaluation;experimental study;Exposure disparity;Exposure to;Gene Expression;Gene Expression Profile;Gene Targeting;Genes;genetic risk factor;Genetic Transcription;genome-wide analysis;Genomics;Geography;Goals;Hippocampus;Human;Impaired cognition;in vivo;Incidence;insight;Intervention;late life;Lead;lead exposure;Life;lifetime risk;Link;Longitudinal Studies;Maps;Measures;Methods;Modeling;modifiable risk;Molecular;Molecular Conformation;mouse model;Mus;National Institute on Aging;Neurodegenerative Disorders;Neuroglia;Neurons;neurotoxicology;novel;Oligodendroglia;Pathologic;Pathology;Pathway interactions;Pattern;Perinatal;Perinatal Exposure;Population;Predisposition;prevent;Prevention;Productivity;Public Health;Race;Recommendation;Research;Research Design;response;Risk;Risk Factors;sex;sex variable;single-cell RNA sequencing;Socioeconomic Status;Specificity;Strategic Planning;symposium;Testing;Time;Tissues;toxicant;Toxicant exposure;Toxicology;transcriptome sequencing;transcriptomics;Translations;ultra high resolution

PROJECT_TITLE: Risk of Alzheimer's Disease and Related Dementias from Perinatal Lead Exposure: Brain Region and Cell Type Effects

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Prevention

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: This research aims to apply advanced mathematical modeling, wearable electronics and artificial intelligence to evaluate individual’s energy and nutrient intake automatically and objectively.

PI_NAMEs: SUN, MINGUI  (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: Address;Adopted;Adult;Affect;Algorithms;American;Artificial Intelligence;artificial intelligence algorithm;Biomedical Engineering;Biomimetics;burden of illness;cancer type;Cardiovascular Diseases;Cellular Phone;Cessation of life;Chest;Child;Chronic Disease;Complex;computerized data processing;Consumption;convolutional neural network;Country;Data;Databases;deep learning;design;Developed Countries;Devices;Diabetes Mellitus;Diet;dietary;Dietary Assessment;Dietary intake;Dietetics;Dimensions;Eating;effective intervention;Electronics;Emerging Technologies;empowerment;Evaluation;Expert Systems;Eye;Feedback;field study;Food;Food Energy;Future;Goals;good diet;Habits;Health;Health care facility;Healthcare;Heart Diseases;Human;human disease;human subject;Image;improved;Individual;infancy;Intake;Label;Life;Life Expectancy;Life Style;Link;Malignant Neoplasms;Manuals;mathematical model;microelectronics;mimetics;Modeling;neural network;Nutrient;Nutritional;Nutritional Science;Obesity;obesity management;operation;Output;overweight adults;Participant;Patient Self-Report;Performance;Persons;Play;Privacy;Process;Public Health;Records;Reporting;Research;Research Personnel;Risk;Risk Factors;robotic system;Role;Shapes;Signal Transduction;success;System;Technology;tool;Training;training data;Unhealthy Diet;Update;validation studies;Visual;wearable device

PROJECT_TITLE: A Human-Mimetic AI System for Automatic, Passive and Objective Dietary Assessment

STUDY_SECTION: BCHI

STUDY_SECTION_NAME: Biomedical Computing and Health Informatics Study Section[BCHI]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Digestive Diseases;HIV/AIDS;Infectious Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

PHR: Project Narrative The proposed research is relevant to public health; it will identify mechanisms of continuous chronic immune activation and gut barrier defects in a new stem cell-derived 3D organoid model. Such mechanisms would have substantial benefit to the field and potentially lead to new therapies improving patients' health and life span. The project is well aligned with this RFA and relevant to NIH's mission as it addresses HIV-associated comorbidities, coinfections and complications and fulfills one of the high-priority topics of research for support using AIDS- designated funds.

PI_NAMEs: OTT, MELANIE MARIA (contact);SOMSOUK, MA

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: 3-Dimensional;Acceleration;Acquired Immunodeficiency Syndrome;Acute;Address;Affect;antiretroviral therapy;Biology;Biology of HIV Infection;Biopsy;Cell Death;cell injury;Cell Separation;cell type;Cells;Chronic;Circulation;Clinical;clinical infrastructure;clinical predictors;Clinical Research;co-infection;Coculture Techniques;Colon;comorbidity;Culture Media;Data;Defect;Development;Differentiation and Growth;Disease;Disease Progression;Early treatment;Enterocytes;Enteroendocrine Cell;Epithelial Cells;epithelium regeneration;Equilibrium;Etiology;Experimental Designs;experimental study;Failure;Formulation;Foundations;Functional disorder;Funding;gastrointestinal;gastrointestinal epithelium;Gastrointestinal tract structure;Genetic Transcription;Goals;Goblet Cells;Grant;Growth;Growth and Development function;gut inflammation;Health;HIV;HIV Infections;Human;immune activation;Immunologics;Impairment;improved;in vitro Model;in vitro testing;in vivo;Individual;Infection;Inflammation;Inflammatory Bowel Diseases;innovation;insight;Intervention;intestinal epithelium;Intestines;Laboratories;Large Intestine;Length;life span;Link;Lipopolysaccharides;Literature;Liver diseases;lonely individuals;Measures;Mediator;microbial;microbial products;Mission;Modeling;Molecular;Molecular Biology;molecular targeted therapies;Morphology;mortality;Natural regeneration;novel;novel therapeutic intervention;novel therapeutics;Observational Study;Organ;Organoids;Outcome;Paneth Cells;patient subsets;Patients;persistent symptom;Persons;Plasma;Process;Public Health;Publishing;Recovery;Regenerative capacity;Research;Research Support;self organization;single-cell RNA sequencing;SIV;Small Intestines;stem cell biology;stem cell function;stem cell organoids;stem cell proliferation;stem cells;Subgroup;success;systemic inflammatory response;T-Lymphocyte;Technology;Testing;Therapeutic Intervention;three dimensional structure;TNF gene;United States National Institutes of Health;virology

PROJECT_TITLE: Modeling intestinal dysfunction in HIV infection with organoid technology


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Prevention

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative SARS-CoV-2 wastewater surveillance, an innovative tool for monitoring SARS-CoV-2 in the general population, has been widely adopted nationwide (currently representing 100+ million Americans). This project will leverage these wastewater surveillance data to develop a cutting-edge model system for study of SARS-CoV-2 dynamics, and prediction of COVID-19 outcomes, and to inform better preparedness for future COVID-19 epidemics.

PI_NAMEs: YANG, WAN  (contact)

PROJECT_TERMS: 2019-nCoV;Accounting;Address;Adopted;American;Awareness;Back;behavior test;Biological Models;Case Study;Cessation of life;Cities;Communities;community transmission;County;COVID-19;COVID-19 detection;COVID-19 monitoring;COVID-19 pandemic;COVID-19 prevalence;COVID-19 surveillance;COVID-19 testing;Data;Data Set;Detection;Development;Disease Surveillance;diverse data;Emergency department visit;Epidemiology;Evolution;flexibility;Future;General Population;Goals;Home;home test;Hospitalization;Immunity;improved;Individual;Infection;innovation;Intervention;Location;Maps;Measures;model building;model design;Modeling;Neighborhoods;New York City;novel;Outcome;pandemic disease;pilot test;Plants;Population;predictive modeling;Predisposition;Prevalence;programs;Public Health;Readiness;Reporting;research clinical testing;Research Personnel;response;RNA;SARS-CoV-2 infection;SARS-CoV-2 transmission;Secondary Immunization;surveillance data;System;Testing;Time;tool;transmission process;trend;Uncertainty;United States;user-friendly;Vaccination;Vaccines;Variant;Virus Shedding;wastewater surveillance;Work

PROJECT_TITLE: Using wastewater surveillance data to study SARS-CoV-2 dynamics and predict COVID-19 outcomes

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Neurosciences;Pain Research

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Humans express 10 different TMEM16 family members that are expressed in a tissue specific manner, and through their action as ion channels and/or lipid scramblases, they have been implicated in normal physiology such as blood coagulation, nociception, and protection from inflammatory arthritis as well as diseases such as cancer. Unfortunately, it remains unclear how these proteins flip lipids, select one ion over another, and whether all members accomplish these tasks in the same manner. The mechanistic studies outlined here will attempt to answer these questions at the atomic level potentially revealing new therapeutic avenues to treat diseases ranging from stroke to cancer.

PI_NAMEs: GRABE, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Anions;Binding;Binding Sites;Biological;Biological Phenomena;biophysical properties;Blood coagulation;Blood Coagulation Disorders;Blood Platelets;Brain region;Calcium;Cell membrane;Cell Physiology;Cells;Charge;Chloride Channels;Coagulation Process;Collaborations;Cryoelectron Microscopy;Data;Dedications;design;Development;Disease;Electrophysiology (science);Event;Exhibits;experimental study;Exposure to;Family;Family member;Functional disorder;Human;hydrophilicity;Immune response;Inflammatory;Inflammatory Arthritis;insight;Ion Channel;Ions;Joints;Kinetics;Knowledge;Label;Life;link protein;Lipid Bilayers;Lipid Binding;Lipids;Malignant Neoplasms;Measures;member;Membrane;Membrane Proteins;microvesicles;Modeling;Molecular;Molecular Conformation;Muscular Dystrophies;Mutagenesis;mutant;Names;neuronal excitability;Neurons;Nociception;Nociceptors;novel therapeutics;Pain management;paralogous gene;Pathway interactions;Permeability;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylserines;Physiological;Physiological Processes;Physiology;Play;Production;Property;protein function;Proteins;Protocols documentation;Publishing;Resolution;Role;Sampling;Scott syndrome;screening;Signal Transduction;simulation;Site;Site-Directed Mutagenesis;small molecule;Specificity;Stroke;structural determinants;Structure;targeted treatment;Testing;Thinness;Tissues;tumor progression;Vesicle;voltage

PROJECT_TITLE: Ion permeation, lipid flipping, and membrane remodeling by TMEM16 proteins

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Digestive Diseases;Liver Disease

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative The intrahepatic biliary tree is essential for life. This project will test a new model of how this tubular network self-organizes to form its own signaling niche. This `inside-out' model has important implications for safely harnessing biliary morphogenesis in regeneration and limiting or repairing it in disease.

PI_NAMEs: MCCLATCHEY, ANDREA I (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: 3-Dimensional;Acquired Abnormality;Adopted;Adult;Apical;Architecture;Back;Beds;Behavior;Bile fluid;Biliary;biliary tract;blastocyst;Cell division;Cell Lineage;Cells;Cellular Structures;Cholangiocarcinoma;Chronic;Clinical;Congenital Abnormality;Coupled;Development;Diameter;Disease;Duct (organ) structure;E-Cadherin;Embryo;Epithelium;Feedback;Feeds;fetal;Fibroblast Growth Factor;Fibroblast Growth Factor Receptors;Genetic;Goals;Hepatocyte;Human;in vivo;insight;Intercellular Junctions;intrahepatic;Intrahepatic bile duct;lateral line;Legal patent;Life;Ligands;Link;Liver;Liver diseases;Liver parenchyma;Malignant - descriptor;Malignant Neoplasms;mechanical force;Modeling;Morphogenesis;mutant;Mutation;Natural regeneration;notch protein;novel;Organ;Patients;pharmacologic;Process;programs;Proliferating;Psychological reinforcement;Publishing;quantitative imaging;Reaction;recruit;regeneration potential;regenerative;repaired;Research Personnel;Role;Runaway;self organization;Shapes;Signal Transduction;spatial relationship;spatiotemporal;Structure;Surface;System;Testing;three-dimensional modeling;Time;tool;trafficking;transdifferentiation;Trees;Tube;Tubular formation;tumor;Tumor-Derived;tumorigenesis;Work;Zebrafish

PROJECT_TITLE: Inside-out construction of the biliary system

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Prevention

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Subjective cognitive symptoms are common in older adults, but increasing evidence suggests that for a subset of individuals, noticing a change in memory may be an early sign of underlying Alzheimer's disease (AD). The goal of the proposed study is to track subjective cognitive symptoms over time, including an electronic at-home assessment that can be completed on a more frequent basis than questionnaires given at the clinic. The pattern of subjective cognitive symptoms will be compared with in vivo markers of AD pathology; amyloid and tau, and decline in performance on standardized cognitive measures.

PI_NAMEs: AMARIGLIO, REBECCA E (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Age;aging brain;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;amyloid imaging;Anxiety;associated symptom;autosomal dominant Alzheimer's disease;Biological Markers;carrier status;Cellular Phone;Clinic;Clinical;clinical diagnosis;clinical predictors;Cognitive;cognitive function;cognitive performance;cognitive testing;cohort;common symptom;Communities;Complement;Computers;Cross-Sectional Studies;Demographic Impact;direct application;Disease Marker;Disease Progression;Early Diagnosis;Education;Electronics;entorhinal cortex;Episodic memory;Etiology;Evolution;executive function;Frequencies;Genetic;Glean;Goals;high risk;Hippocampus;Home;Impaired cognition;improved;in vivo;Individual;Inferior;Investigation;Knowledge;Magnetic Resonance Imaging;Measures;Memory;Memory Disorders;Methods;Modeling;Moods;National Institute on Alcohol Abuse and Alcoholism;Nerve Degeneration;Neurobehavioral Manifestations;Neuropsychological Tests;Neuropsychology;novel strategies;older adult;Older Population;Participant;Patient Self-Report;Pattern;Performance;Persons;Phase;Pittsburgh Compound-B;Positron-Emission Tomography;pre-clinical;Prevention;Prevention trial;Questionnaires;recruit;Reporting;Research;risk prediction;Self Assessment;Severities;Severity of illness;sex;Source;Standardization;Symptoms;Tablets;tau aggregation;tau Proteins;Temporal Lobe;Time;treatment effect;treatment response;treatment strategy;White Matter Hyperintensity

PROJECT_TITLE: Characterizing the evolution of Subjective Cognitive Decline in preclinical Alzheimer's disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Hematology;Orphan Drug;Prevention;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: SAINT LOUIS UNIVERSITY

PHR: Project narrative In the autoimmune disorder called Antiphospholipid Syndrome (APS), the presence of autoantibodies targeting the plasma glycoprotein beta-2 glycoprotein I (b2GPI) is associated with arterial and venous thrombosis as well as pregnancy complications. Understanding how b2GPI becomes immunogenic and how autoantibodies in complex with b2GPI cause the blood to clot remains a top priority in the field. By elucidating the structural architecture of b2GPI free and bound to physiological and pathological ligands, our studies have the potential to shed new light on the pathogenic mechanisms of APS and will enable the development of new diagnostics and therapeutic approaches.

PI_NAMEs: POZZI, NICOLA  (contact)

PROGRAM_OFFICER_NAME: NEIDERT, LESLIE EAVES

PROJECT_TERMS: Address;Affect;Age;Anti-phospholipid Syndrome;Antibodies;Anticoagulants;Antigens;Antiphospholipid Antibodies;Architecture;Area;Arteries;Attention;Autoantibodies;Autoimmune;Autoimmune Diseases;beta 2-glycoprotein I;Binding;Biology;biophysical analysis;Blood;Blood coagulation;Blood Platelets;Blood Vessels;Chemicals;Clinical;clinical investigation;Coagulation Process;Complex;Computer Simulation;conformational conversion;cost;Data;data exchange;design;Detection;detection test;Development;Diagnosis;Diagnostic;Diagnostic Reagent Kits;Diagnostic tests;Disease;disulfide bond;Engineering;Fluorescence Resonance Energy Transfer;follow-up;General Population;Glycoproteins;Goals;Health;Healthcare Systems;Hemorrhage;high risk;Human;Immobilization;Immunoassay;immunogenic;immunogenicity;improved;Individual;information gathering;innovation;Intervention;Investigation;Knowledge;Laboratories;Learning;Life;Life Style;Lifelong disability;Ligands;Link;Low-Molecular-Weight Heparin;Mammalian Cell;Medicine;Molecular;Molecular Conformation;Myocardial Infarction;novel;novel diagnostics;novel therapeutic intervention;novel therapeutics;obstetrical complication;Oxidation-Reduction;Oxidoreductase;pathogenic autoantibodies;Pathogenicity;Pathologic;patient population;Patients;Performance;Pharmaceutical Preparations;pharmacologic;Physicians;Physiological;Physiology;Plasma;Pregnancy Complications;prevent;Primary Care;Property;prophylactic;Protein Disulfide Isomerase;Protein Engineering;Protein Glycosylation;protein purification;Pulmonary Embolism;rational design;Recombinants;Recurrence;Regimen;Reproducibility;Research Project Grants;Risk;Risk Factors;Roentgen Rays;Role;Scientist;Side;side effect;Signal Pathway;single molecule;Site-Directed Mutagenesis;Societies;Spectrum Analysis;Standardization;Stroke;structural biology;structural determinants;Structure;Surface;System;Testing;Therapeutic;Thrombophilia;Thrombosis;thrombotic;Time;Uncertainty;urgent care;Vascular System;Veins;Venous Thrombosis;Visualization;Work;X-Ray Crystallography

PROJECT_TITLE: Structural Studies of Beta-2 glycoprotein I in the Antiphospholipid Syndrome

STUDY_SECTION: HT

STUDY_SECTION_NAME: Hemostasis and Thrombosis Study Section.  Committee was terminated on 11/30/2020. [HT]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Pediatric;Prevention;Primary Immunodeficiencies;Rare Diseases;Vaccine Related

PHR: NARRATIVE Vaccine hesitancy and the emergence of new SARS-CoV-2 variants are major hurdles in the control of SARS- CoV-2 infection but is also impeded by the lack of specific vaccine guidelines for the inclusion of people with primary immunodeficiency disorders. Individuals with X-linked agammaglobulinemia lack B cells and antibodies, face recurrent infections, depend on lifelong gammaglobulin infusions, but maintain their ability to respond to most vaccines due to their intact T cell development. Therefore, we posit that XLA patients will benefit from mRNA SARS-CoV-2 vaccination through the induction of virus specific T cells that will prevent severe COVID- 19 outcomes.

PI_NAMEs: DE PARIS, KRISTINA  (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 2019-nCoV;Activities of Daily Living;Adult;Affect;Agammaglobulinaemia tyrosine kinase;Age;age group;Antibodies;Antibody Response;Antigen-Presenting Cells;antigen-specific T cells;Antigens;APC Vaccine;Authorization documentation;B-Cell Development;B-Lymphocytes;Bacterial Infections;Birth;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Child;cohort;congenital immunodeficiency;COVID-19;COVID-19 pandemic;COVID-19 susceptibility;COVID-19 vaccination;COVID-19 vaccine;cross reactivity;cytokine;Data;Deficiency Diseases;Dendritic Cells;Development;Disease;Face;Foundations;Gamma globulin;Genetic Diseases;Goals;Guidelines;Health;Health Personnel;Health Policy;Human;Immune;Immune response;Immunization;Immunocompetent;Immunocompromised Host;Immunologic Deficiency Syndromes;Impairment;In Vitro;Individual;Infection;Infection prevention;Influenza;influenza virus vaccine;Infusion procedures;Life;Ligands;Link;Lung infections;lung injury;male;Mature B-Lymphocyte;Measures;Mediating;Memory;Messenger RNA;monocyte;Mutation;neutralizing antibody;Organ;Outcome;Participant;Patients;Persons;Pfizer-BioNTech COVID-19 vaccine;Play;Population;prevent;Production;Proteins;Receptor Signaling;recurrent infection;RNA vaccination;RNA vaccine;Role;SARS-CoV-2 infection;SARS-CoV-2 spike protein;SARS-CoV-2 variant;severe COVID-19;sex;Signal Transduction;T cell response;T-Cell Development;T-Lymphocyte;Toll-like receptors;United States;Vaccination;vaccine candidate;Vaccine Clinical Trial;vaccine distribution;vaccine hesitancy;Vaccines;Variant;variants of concern;Viral;Virus;Virus Activation;Virus Diseases;Virus Replication;Vulnerable Populations;X-Linked Agammaglobulinemia

PROJECT_TITLE: Vaccine-induced SARS-CoV-2-specific T cell responses in patients with X-linked Agammaglobulinemia


ORG_CITY: WALTHAM

ORG_DEPT: PHYSICS

ORG_NAME: BRANDEIS UNIVERSITY

PHR: PROJECT NARRATIVE The robust establishment of correct shape is essential for proper tissue function. Tissue shape change is a mechanical process that necessitates the coordinated force generation and motion of thousands of cells. Identifying how physically interacting cells mechanically respond to challenging conditions and modify their behavior to still sculpt the correct final shape will shed light onto many congenital disorders that result from morphogenetic dysregulation.

PI_NAMEs: DUCLOS YEVICK, HANNAH GABRIELLE (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Actomyosin;Address;Adopted;Affect;Algorithms;Architecture;Behavior;Biophysics;Cell Communication;Cell Culture Techniques;Cell Size;Cells;Cellular biology;computer science;confocal imaging;Congenital Abnormality;Congenital Disorders;congenital heart abnormality;constriction;Cytoskeleton;Data;Development;Developmental Biology;Disease;Drosophila genus;Early Diagnosis;Embryo;Engineering;Ensure;Exhibits;fetal;fetal medicine;fly;Galaxy;Generations;Genetic;Heterogeneity;Image;In Vitro;in vivo;interdisciplinary approach;Light;Link;Location;Machine Learning;malformation;Maternal-fetal medicine;mechanical force;mechanical properties;mechanical stimulus;Mechanics;Molecular;Morphogenesis;Morphology;Motion;Movement;Myosin ATPase;Neural Tube Defects;Noise;novel;optogenetics;Organism;Pathway Analysis;Pattern;Population;Process;programs;Property;Proteins;Regulation;Reproducibility;Shapes;Structure;Techniques;Testing;theories;Time;tissue-level behavior;Tissues;transmission process;Transportation;Work

PROJECT_TITLE: Investigating how mechanical connectivity yields developmental robustness

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Pancreatic Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases

PHR: PROJECT NARRATIVE Pancreatic cancer is a significant health problem in the United States with very poor survival and disproportionate burden across race/ethnicity. Our objective is to apply an integrative systems biology approach, incorporating epidemiologic, clinical, genetic and metabolomic data, to improve the prediction of pancreatic cancer risk in a racially heterogeneous population. By refining the identification of high-risk individuals, our study will help to establish new strategies for targeted prevention and early detection and reduce the overwhelming burden of this lethal disease.

PI_NAMEs: HUANG, BRIAN  (contact)

PROGRAM_OFFICER_NAME: ROTUNNO, MELISSA

PROJECT_TERMS: African American population;Amino Acids;Asia;Asian ancestry;Asian population;associated symptom;biobank;Biological;Biological Assay;Biological Markers;Blood specimen;California;Cancer Etiology;cancer risk;Caucasians;Cessation of life;Clinical;Clinical Data;cohort;Cohort Studies;comorbidity;Data;data integration;Databases;design;Diagnosis;Diagnostic;Disease;Early Diagnosis;epidemiologic data;Epidemiology;Ethnic Origin;Ethnic Population;Etiology;Europe;European;European ancestry;Evaluation;Functional disorder;Gastrointestinal Diseases;gastrointestinal symptom;Genetic;genetic variant;genome-wide;genomic data;Genomics;Health;high risk;high risk population;Hospitals;improved;Incidence;Individual;insight;Japanese American;Life Style;Malignant neoplasm of pancreas;Malignant Neoplasms;Medicare claim;Mentors;Metabolic;Metabolic syndrome;metabolomics;Minority;Minority Groups;Modeling;mortality;multi-ethnic;Native Hawaiian;neoplasm registry;novel;Organ;Pancreas;pancreatic cancer model;Participant;Pathogenesis;Pathway interactions;Pattern;Performance;Phase;Population;Population Heterogeneity;predictive modeling;Prevention;Prognosis;Prospective cohort;Questionnaires;Race;racial diversity;Research;Research Design;Resources;Risk;Risk Factors;risk prediction model;risk stratification;Running;Sampling;Screening for cancer;sex;Standardization;Subgroup;Survival Rate;Symptoms;Systems Biology;Techniques;United States

PROJECT_TITLE: Integrating epidemiologic, clinical, genomic and metabolomic profiles to predict pancreatic cancer risk in a multiethnic population


ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE Acute and chronic antibody-mediated rejection remain among the leading causes of renal allograft loss. The proposed studies will investigate the mechanisms by which posttransplant inflammation initiates and amplifies the generation of pathogenic alloantibody. The results will fill several critical gaps in current knowledge of humoral alloimmune responses to vascularized organ transplants and identify potential targets of therapeutic intervention to inhibit antibody-mediated rejection.

PI_NAMEs: VALUJSKIKH, ANNA  (contact)

PROGRAM_OFFICER_NAME: KULKARNI, SHILPA S

PROJECT_TERMS: Acute;adaptive immune response;adaptive immunity;Address;Affect;Affinity;Alloantigen;Allografting;Anatomy;Animals;antibody-mediated rejection;Antigen-Presenting Cells;Antigens;assault;B-Cell Activation;B-Lymphocyte Subsets;B-Lymphocytes;Blood;Cadaver;Cardiovascular Diseases;CD80 Antigens;Cell Adhesion Molecules;Cell Maturation;Cell Physiology;Cells;Cellular biology;chemokine;Chronic;Chronic Kidney Failure;Clinical;Clinical Data;Clinical Research;cytokine;Data;Endothelial Cells;Endothelium;Epithelial Cells;exosome;extracellular vesicles;Generations;graft failure;high risk;Histocompatibility Antigens Class II;Human;Immune;Immunoglobulin Class Switching;Impairment;improved outcome;Inflammation;Inflammatory;inhibiting antibody;Injury;Investigation;Ischemia;Isoantibodies;isoimmunity;kidney allograft;Kidney Transplantation;Knowledge;Ligands;Location;Lymphocyte Activation;Mediating;MHC Class II Genes;mortality;mouse model;Mus;Natural Immunity;Organ Donor;Organ Transplantation;Outcome;pathogen;Pathogenicity;Patients;post-transplant;Prevention;Production;receptor;Reperfusion Injury;response;Risk;Risk Factors;Role;Series;Signal Transduction;Source;Spleen;Structure of germinal center of lymph node;T-Lymphocyte;targeted treatment;Testing;Therapeutic Intervention;Time;tissue injury;trafficking;Transplant Recipients;Transplantation;Vascularization

PROJECT_TITLE: Mechanisms of alloantibody production following renal transplantation

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE This research studies individuals who lack an important cellular organelle called peroxisomes Researchers use genome sequencing, blood testing and insights from fruit flies to learn more about these diseases. The research could lead to a better understanding of these diseases for which there are no effective treatments.

PI_NAMEs: WANGLER, MICHAEL FRANCIS (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Address;Adult;Aging;Alzheimer's Disease;Anabolism;Animal Model;autosome;Bile Acid Biosynthesis Pathway;Bile Acids;Biochemical;Biochemical Pathway;Biogenesis;Biological Markers;Biological Process;Biology;Blood Tests;branched chain fatty acid;career;Catabolism;Characteristics;Clinical Research;Code;Data;de novo mutation;Dedications;Defect;Development;Diagnosis;Diagnostic;Disease;Drosophila genus;effective therapy;Eukaryotic Cell;experimental study;Fatty Acids;fly;Functional disorder;Genes;Genetic;Genetic Diseases;genetic manipulation;Genetic Screening;genetic technology;genome sequencing;Genomics;Health;hearing impairment;Human;human disease;human subject;Impairment;improved;in vivo;Individual;innovation;insight;knock-down;Learning;Length;leukodystrophy;life span;Lipids;loss of function;Mediating;Medical;Membrane;Metabolic;Metabolism;metabolome;metabolomics;Methods;Microgyria;model organism;Molecular Probes;mouse model;mutant;Mutation;Nervous System;Nervous System Disorder;Nervous System Physiology;neurodegenerative phenotype;Neurologic;Neurons;novel;Obesity;Organelles;Patients;Pattern;Peroxisomal Disorders;peroxisome;pharmacologic;Phenotype;Phospholipids;Physicians;Plasmalogens;Point Mutation;Production;Proteins;Quality of life;Rare Diseases;rare genetic disorder;Reactive Oxygen Species;Research;Research Personnel;research study;Retinal Degeneration;Role;Science;Scientist;Seizures;Series;Side;Sphingolipids;Sphingomyelins;Study models;System;Technology;Testing;Therapeutic Effect;therapeutic target;tool;translational impact;Variant;Very Long Chain Fatty Acid;X Chromosome

PROJECT_TITLE: Neuronal Mechanisms of Metabolic and Genetic Defects of the Peroxisome

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: CLEMSON

ORG_DEPT: BIOLOGY

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: PROJECT NARRATIVE The work proposed here will yield molecular approaches and tools for manipulation of gene expression in the pathogenic free-living amoebae Naegleria fowleri. Approaches to be developed include those required for gene silencing, gene editing, and transgene expression. The work proposed will provide essential tools for resolving fundamental parasite pathobiology and will also be critical for drug discovery campaigns.

PI_NAMEs: MORRIS, JAMES CULVIN (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Ablation;Address;Alleles;Amoeba genus;Area;Awareness;Basic Science;Binding;Biology;Brain;Categories;Cell Line;chemical genetics;Classification;contaminated water;CRISPR/Cas technology;Death Rate;Detection;Development;drug development;drug discovery;Drug Targeting;druggable target;fighting;Gene Expression;gene function;Gene Silencing;Gene Transfer Techniques;Generations;Genes;Genetic;genetic approach;genetic manipulation;Goals;Infection;inhibitor;interest;Invaded;knockout gene;Life;loss of function;Mediating;Molecular;Mutagenesis;Naegleria;Naegleria fowleri;National Institute of Allergy and Infectious Disease;Nose;novel strategies;novel therapeutics;Organism;Outcome;overexpression;Parasites;pathogen;Pathogenicity;Pathway interactions;Pharmacotherapy;Phenotype;primary amebic meningoencephalitis;Process;promoter;Proteins;Reaction;Reagent;Resistance;RNA Interference;targeted treatment;Technology;Therapeutic;Therapeutic Agents;therapeutic target;tool;transgene expression;Transgenic Organisms;Validation;vector;Work

PROJECT_TITLE: Approaches for genetic manipulation of Naegleria fowleri

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Nutrition;Prevention

ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE Accumulation of lipids in liver (NAFLD) is a widespread problem in the western world, and it can lead to chronic inflammation (NASH) and development of cirrhosis and liver cancer. There is no currently available single- agent pharmacologic treatment for NAFLD and its progress to NASH. We discovered that inhibition of EGFR completely prevents and reverses NAFLD, and we aim to apply these unexpected findings to provide mechanistic understandings and therapeutic alternatives that have direct bearing on NAFLD/NASH pharmacology applicable to humans.

PI_NAMEs: BHUSHAN, BHARAT ;MICHALOPOULOS, GEORGE K (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Adverse effects;Affect;Amphiregulin;Attenuated;Binding;biobank;Cancer Patient;Canertinib;Cell membrane;Cells;Chronic;Chronology;Cirrhosis;Collagen;Complication;Deposition;design;Development;Diet;Dose;Down-Regulation;drinking water;EGF gene;EGFR inhibition;Enzymes;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Exposure to;Family;fast food;Fatty acid glycerol esters;Fatty Liver;feeding;Female;Fibrosis;Freezing;Fructose;Funding;gender difference;Gene Expression Profile;Germ Lines;Glucose;Heparin Binding;Hepatic;Hepatic Stellate Cell;Hepatocyte;Hepatology;Hepatotoxicity;High Fat Diet;Histology;Human;human subject;human tissue;Inflammation;inhibitor;Institutional Review Boards;integrin-linked kinase;Knockout Mice;Ligands;lipid biosynthesis;lipid metabolism;Lipids;Liver;Liver Regeneration;male;Malignant neoplasm of liver;Manuscripts;MET gene;Metabolism;MicroRNAs;Modification;Mus;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;Nutritional;Paraffin Embedding;Pathway Analysis;Pathway interactions;Patients;pharmacologic;Pharmacological Treatment;Pharmacology;Phosphorylation;Phosphotransferases;Population;Predictive Factor;prevent;Primary carcinoma of the liver cells;Process;Production;Proteins;Publishing;receptor;Receptor Protein-Tyrosine Kinases;Regulatory Pathway;Research;response;RNA;Role;side effect;Signal Pathway;Signal Transduction;Signaling Molecule;Signaling Protein;Socioeconomic Factors;stellate cell;Therapeutic;Time;Tissues;Toxic effect;transcription factor;transcriptome sequencing;translational applications;United States National Institutes of Health;Up-Regulation;Western World;women patients;Work

PROJECT_TITLE: Inhibition of EGF Receptor Prevents and Reverses Non-Alcoholic Fatty Liver Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-J(05)]


ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Narrative. Integrin α5β1 is a cell surface protein that directs how cells interact with both other cells and molecules within the extracellular matrix. This grant will explore how different factors change the conformational shape of integrin α5β1, and how those changes in shape affect its ability to interact with an important protein binding partner called fibronectin in blood cells. Insights from this research will shed light on how integrin α5β1 and other related integrins function and will aid the development of drugs to treat diseases that are both dependent on, and exacerbated by integrin function including atherosclerosis, fibrosis, sickle cell disease, and cancer.

PI_NAMEs: SPRINGER, TIMOTHY A (contact)

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: Acceleration;Actins;Adhesions;Affect;Affinity;Amino Acids;Atherosclerosis;Award;Binding;Binding Proteins;Binding Sites;Biological Process;Blood Cells;Cell Adhesion;Cell Communication;Cell Differentiation process;cell motility;Cell surface;Cell Surface Proteins;Cell Surface Receptors;Cells;Compensation;conformational conversion;Coupling;cyanine dye 5;Cytoskeleton;Data;Disease;Disputes;Dissociation;Disulfides;Divalent Cations;drug development;Environment;Equilibrium;Erythropoiesis;Event;experimental study;extracellular;Extracellular Matrix;Fibronectins;Fibrosis;Fluorescence Resonance Energy Transfer;fluorophore;Free Energy;Grant;Hematopoiesis;insight;Integrin alpha5beta1;Integrin beta Chains;Integrin Binding;Integrins;Ions;Kinetics;Knee;Ligand Binding;Ligands;Link;Malignant Neoplasms;Maps;Measurement;Measures;Mediating;Membrane;Metal Ion Binding;Metals;Molecular Conformation;monocyte;Mutate;Mutation;Pathology;Play;Population;Positioning Attribute;rate of change;Reaction;Reporting;Research;Rest;Role;Shapes;Sickle Cell Anemia;single molecule;Site;Structure;Supporting Cell;temporal measurement;Testing;Tissues;Titrations;tool;Total Internal Reflection Fluorescent;Transmembrane Domain;Work

PROJECT_TITLE: Activation trajectories of integrin Î±5Î²1

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: The years from 2001 to 2014, when the United States was engaged in military operations following the September 11th, 2001 terrorist attacks, were momentous in many ways. For the VHA in particular, the post- 9/11 conflicts in Iraq and Afghanistan produced a new generation of returning veterans with deeply complex and challenging mental and physical problems resulting from their combat experiences. Since its inception in 2009, TRACTS has collected a vast array of longitudinal data detailing the complexities of the mental, physical, and brain health of post-9/11 veterans. Our well characterized group of participants is projected to surpass 1000 individuals by 2024. This representative group has allowed us to study the intellectual, emotional, neural, and molecular correlates of brain injury and traumatic experiences, which will lead directly to improved treatment for post-9/11 veterans now and into the future as they age.

PI_NAMEs: JORGE, RICARDO E.;MILBERG, WILLIAM P (contact)

PROJECT_TERMS: Acceleration;Afghanistan;Age;Area;Biological;Boston;Brain Concussion;brain health;Brain Injuries;Brain Stem;Caring;Center for Translational Science Activities;Central Nervous System;Clinical;Clinical Research;cohort;combat;Communities;comorbidity;Complex;Data;density;Development;Diagnosis;Emotional;experience;functional status;Funding;Future;Generations;Genetic;Genomics;Health;Healthcare Systems;improved;Individual;innovation;insight;Iraq;Knowledge;Lead;Life;life span;Longitudinal cohort;Magnetic Resonance Imaging;magnetic resonance imaging/electroencephalography;Medical;Medical center;Mental Health;mild traumatic brain injury;military operation;military service;Mission;Modeling;Molecular;multidisciplinary;multimodality;neural;Neurobiology;neuroimaging;outcome prediction;Participant;Pathway interactions;phenomics;Phenotype;physical conditioning;physical symptom;Population;post 9/11;Post-Traumatic Stress Disorders;prisma;programs;Protons;Psyche structure;psychologic;psychological symptom;Rehabilitation therapy;Research;Research Personnel;Role;Scanning;Site;Social Functioning;stress disorder;stress related disorder;Symptoms;System;Techniques;Terrorism;Training;Trauma;Traumatic Brain Injury;Treatment Effectiveness;United States;United States National Institutes of Health;Veterans;Vocation

PROJECT_TITLE: Translational Research Center for Traumatic Brain Injury and Stress Disorders (TRACTS)

STUDY_SECTION: RRDC

STUDY_SECTION_NAME: Centers, Research Enhancement Award Program and Consortiums[RRDC]


ORG_CITY: CAMBRIDGE

ORG_NAME: FOOD ALLERGY SCIENCE INITIATIVE, INC.

PHR: NARRATIVE This program project will study a poorly understood area of food allergy research to investigate how the immune and neural systems interact to regulate the response to food allergen. We bring together leading immunologists and neuroscientists in an integrated approach to allow us to answer questions that could not be asked using traditional funding mechanisms.

PI_NAMEs: MEDZHITOV, RUSLAN  (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Abdominal Pain;Address;Affect;Afferent Neurons;Allergens;Allergic Disease;Allergic inflammation;allergic response;Anaphylaxis;Animal Model;Antibodies;Antigens;Area;Behavior;Bioinformatics;bioinformatics tool;Cell Communication;Cell Maturation;Cells;Central Nervous System;Child;Communication;complement system;Cues;cytokine;Dedications;Dendritic Cells;design;detection of nutrient;Development;Diarrhea;dietary;Disease;Dissection;Enteric Nervous System;Enteroendocrine Cell;Epithelial Cells;Epithelium;Evaluation;expectation;Food;food allergen;Food Hypersensitivity;Funding Mechanisms;GDF15 gene;Goals;Immune;Immune response;Immune system;Immunologist;Immunology;Incidence;Individual;Inflammation Mediators;information processing;innovation;insight;intestinal epithelium;Intestines;Investigation;Life;Logic;Lymphocyte;Maps;mast cell;Modality;Monitor;Mucous body substance;Mucous Membrane;Nausea;Nervous System;neural;Neurobiology;Neuroimmune;neuronal circuitry;Neurons;neurotransmission;new therapeutic target;novel;Nut Hypersensitivity;Organism;Outcome;Pathway interactions;Patients;Peristalsis;Persons;Phytochemical;Play;Prevalence;Production;programs;Reaction;receptor;Recording of previous events;Reflex action;Research;Research Personnel;response;Role;Science;Seminal;Sensory;sensory input;Sensory Thresholds;Spinal Ganglia;Sum;System;Therapeutic;Therapeutic Intervention;Toxin;Transgenic Organisms;translational impact;United States;Vomiting;Work

PROJECT_TITLE: The Role of Neuroimmune Pathways in Food Allergies

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 PT-I (S1)]


NIH_SPENDING_CATS: Digestive Diseases;Food Allergies

PI_NAMEs: OLSEN, CHRISTINE  (contact)

PROJECT_TERMS: Advisory Committees;Agreement;Allergic Disease;Bioinformatics;cohesion;Collaborations;Communication;Data Storage and Retrieval;Discipline;Disputes;Doctor of Philosophy;Ensure;Expenditure;Experimental Designs;Food Hypersensitivity;food science;Fostering;Foundations;Goals;Grant;Guidelines;Hand;Immune system;insight;Institution;Israel;Leadership;Logistics;Medical center;medical schools;meetings;member;migration;Monitor;Nervous System;Neuroimmune;new technology;Office of Administrative Management;Outcome;Participant;Pathway interactions;Persons;Play;Productivity;Program Research Project Grants;programs;Progress Reports;Quality Control;Recording of previous events;Reporting;Research Personnel;Resource Sharing;Resources;Role;Science;Scientist;Strategic Planning;success;symposium;synergism;technology/technique;Therapeutic;Transgenic Organisms;Travel;United States National Institutes of Health;Universities;virtual;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Food Allergies;Genetics;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

PI_NAMEs: LOWELL, BRADFORD B (contact)

PROJECT_TERMS: Alleles;Archives;Categories;cell repository;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Consultations;Cryopreservation;DNA;Embryo;embryo cell;embryo cryopreservation;embryonic stem cell;Engineered Gene;Engineering;Enterobacteria phage P1 Cre recombinase;experience;Food Hypersensitivity;Gene Deletion;Gene Modified;Gene Targeting;Generations;Genes;Genetic Engineering;Genetic Markers;Genetically Engineered Mouse;Guide RNA;Harvest;Implant;Inbred BALB C Mice;Institution;Knock-in Mouse;knockout gene;Maps;Modification;Monitor;Motor Neurons;Mouse Embryonic Stem Cells;mouse genetics;mouse genome;Mouse Strains;Mus;Mutant Strains Mice;Neuroimmune;Neurons;Pathway interactions;preimplantation;Proteins;Reagent;recombinase;repository;Research;Research Personnel;Role;Running;Services;Site;Source;sperm cell;sperm cryopreservation;stem cell based approach;stem cell technology;Tail;tool;Transgenes;Transgenic Mice;Transgenic Organisms;Work;zygote

PROJECT_TITLE: Transgenic Core


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Food Allergies;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Nutrition

PI_NAMEs: CARROLL, THOMAS S (contact)

PROJECT_TERMS: Allergic;analysis pipeline;Atlases;Benchmarking;Bioinformatics;bioinformatics resource;Cell Communication;Cell Nucleus;cell type;Cells;Code;Colon;Computer software;Data;data access;Data Analyses;data analysis pipeline;data integrity;data management;data pipeline;Data Set;design;Documentation;Duodenum;Ensure;Environment;Epithelial Cells;Epithelium;experience;experimental study;Food;Food Hypersensitivity;ganglion cell;gastrointestinal epithelium;GDF15 gene;Gene Expression Profiling;Genomics;Goals;graphical user interface;Human Resources;IgE;ileum;Image;Immune;interactive tool;Label;Laboratories;Lamina Propria;Life Cycle Stages;Ligands;Maintenance;Maps;mast cell;member;Mesentery;Methodology;Mus;Neuroimmune;Neurons;Paper;Pathway interactions;Phytochemical;Process;programs;Protocols documentation;Reaction;receptor;Reproducibility;Research Personnel;Resources;Role;Scientist;Secure;Series;Services;single cell analysis;single nucleus RNA-sequencing;Standardization;success;synergism;tool;Toxin;Training;transcriptome;transcriptome sequencing;transcriptomics;translating ribosome affinity purification and RNA-sequencing;Universities;web-accessible;Work

PROJECT_TITLE: Bioinformatics Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Digestive Diseases;Food Allergies;Infectious Diseases;Neurosciences;Nutrition;Prevention

PI_NAMEs: LIBERLES, STEPHEN DANIEL (contact)

PROJECT_TERMS: Ablation;Afferent Neurons;Allergens;Allergic Reaction;allergic response;Anaphylaxis;Anatomy;Atlases;avoidance behavior;Behavior;Behavioral;Brain;Breathing;Calcium;Cells;Communication;Complex;Coughing;Data;Desire for food;Dorsal;Electric Stimulation;Esthesia;Fever;Fiber;fighting;food allergen;Food Hypersensitivity;Foundations;GDF15 gene;Genetic;gut-brain axis;Heart Rate;Image;Immune;immune function;Immune response;Immune system;in vivo imaging;Infection;Inflammatory;influenza infection;Knock-in Mouse;Lethargies;Maps;Measures;Mediating;Medical;Modeling;Motility;Motor;Motor Neurons;Nausea;Nervous System;neural circuit;neurogenetics;Neuroimmune;neuronal circuitry;Neurons;optogenetics;Organ;Outcome;Pain;Parasympathetic Nervous System;pathogen;Pathway interactions;Photometry;Physiological;Physiology;Play;programs;receptor;Reflex action;response;Rest;Role;Sensory;sensory input;sensory mechanism;Stereotyping;Structure of area postrema;Sympathetic Nervous System;Symptoms;therapy design;Toxin;transmission process;Vagus nerve structure;Visceral;Work

PROJECT_TITLE: Project 2: Neuroimmune Interaction Mechanisms in Food Allergy


PROJECT_TERMS: Abdominal Pain;Acute;Afferent Neurons;Allergens;Allergic;allergic response;Anaphylaxis;Antibodies;Antibody-Producing Cells;Antigens;Automobile Driving;avoidance behavior;B-Lymphocytes;Behavior;Behavioral;behavioral response;Binding;candidate identification;Cell Communication;cell type;Cells;Clinical Research;Coculture Techniques;Colon;colonic crypt;cysteinyl leukotriene receptor;cysteinyl-leukotriene;cytokine;Data;Development;Diarrhea;Drops;Enzymes;Epithelial Cells;Epithelium;Family member;Fibrinogen;Food;food allergen;food antigen;Food Hypersensitivity;Frequencies;gastrointestinal;GDF15 gene;Gene Expression Profile;Generations;Genetic;Genetic Transcription;Goals;Grant;Growth Factor;Human;IgE;IgG1;Immune response;Immunity;Immunologic Memory;Immunologics;In Vitro;in vivo;Inbred BALB C Mice;Individual;Ingestion;inhibitor;intestinal epithelium;Intestines;intraepithelial;Investigation;Knock-out;Knockout Mice;Large Intestine;Leukotrienes;LoxP-flanked allele;Lung;Maintenance;Malaise;Maps;mast cell;Mediating;Mediator;Microscopy;migration;Modeling;mouse model;Mus;Myeloid Cells;Nausea;Neuroimmune;Neurons;novel therapeutic intervention;novel therapeutics;Oral;Organoids;Pathogenesis;Pathway interactions;pharmacologic;Phase;Physiological;Play;Population;preclinical study;prevent;Production;Proteins;receptor;response;Role;Signal Transduction;Skin;Small Intestines;Sorting;Stains;Stem Cell Factor;Stress;Structure of area postrema;Symptoms;Temperature;Testing;Tissues;transcriptome sequencing;Vomiting

PROJECT_TITLE: Project 1: Mast cell orchestration of epithelial and neuronal responses


PI_NAMEs: MUCIDA, DANIEL S (contact)

PROJECT_TERMS: 3-Dimensional;Address;Afferent Neurons;Allergic;allergic response;Binding;Bioinformatics;Biological Assay;Brain;Cell Communication;Cell Nucleus;Cell Physiology;cell type;Cells;Collaborations;Colon;Communication;Complement;detection of nutrient;Disease;Duodenum;Enteral;Enteroendocrine Cell;Epithelial Cells;Epithelium;experimental study;Food;food antigen;Food Hypersensitivity;gastrointestinal epithelium;Gastrointestinal tract structure;Gene Expression;Gene Expression Profile;Genetic;genetic approach;Genetic Transcription;Genetically Engineered Mouse;Hypersensitivity;ileum;Image;Imaging Device;Immune;Immune system;In Vitro;in vivo;Inbred BALB C Mice;Individual;Interneurons;intestinal epithelium;Intestines;Irritable Bowel Syndrome;Label;Large Intestine;microbiota;Modeling;Monitor;Morphology;Motor Neurons;mouse genetics;Mouse Strains;Multiple Sclerosis;Mus;Nervous System;Neuroglia;Neuroimmune;neuronal circuitry;Neurons;Nuclear;Organoids;Pathway interactions;Phase;Physiology;Play;Process;programs;Reporter;Reporter Genes;Reproducibility;Role;Sensory;Severities;Signal Transduction;Small Intestines;sortase;Sorting;Spinal Cord;Surface;Testing;Tissues;tool;Transgenic Organisms

PROJECT_TITLE: Project 3: Physical neuro-immune interactions during food allergy


NIH_SPENDING_CATS: Microbiome;Nutrition

PHR: Hydrogen sulfide is paradigmatic of the rich interplay between host and gut microbial metabolism that is influenced by diet, and in turn, influences whole-body sulfide homeostasis. Our laboratory has been at the forefront of deciphering how sulfide, by reversibly poisoning respiration, also remodels host redox and energy metabolism. In the next cycle, our studies will illuminate how host sulfide metabolism is regulated, and reveal the molecular underpinnings of its intersections with oxygen metabolism in the context of normal physiology and disease.

PI_NAMEs: BANERJEE, RUMA V (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Active Sites;aerobic glycolysis;Affinity;Allosteric Regulation;Biochemical;Biogenesis;Biology;Biosensor;Brain Pathology;carboxylation;Cell model;Chemicals;Citric Acid Cycle;Clinical;cofactor;Colorectal Cancer;complex IV;CRISPR interference;Data;Diet;dietary;Disease;Electron Transport;Electrons;Energy Metabolism;enzyme pathway;Epithelium;flexibility;Foundations;Fumarates;Funding Mechanisms;Genetic Models;Genotype;gut microbes;gut microbiota;Health;Homeostasis;Hydrogen Sulfide;Hypoxia;innovation;intestinal epithelium;Laboratories;Lactobacillus reuteri;Leigh Disease;Lipids;live cell imaging;Membrane Potentials;Metabolic;Metabolism;metabolomics;Methionine;microbial;microbial composition;microbial host;Microscopic;Mitochondria;mitochondrial membrane;Modeling;Molecular;Monitor;Morphology;multiple omics;Mus;Mutation;oxidation;Oxidation-Reduction;Oxidoreductase;Oxygen;Physiology;Plastic Embedding;Poisoning;programs;Quinones;Reaction;Respiration;response;Signal Transduction;Sulfides;Sulfur;Techniques;Toxic effect;transcriptome sequencing;Tumor Burden;vapor

PROJECT_TITLE: Sulfide metabolism and signaling

STUDY_SECTION: MRAE

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - E Study Section[MRAE]


NIH_SPENDING_CATS: Bioengineering;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: RICHARDSON

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: Project Narrative (Relevance) The detailed understanding of the mechanisms by which enzymes maintain, repair and modify DNA is extremely important since errors in the genome can often be key for the development of a large number of diseases. This project focuses on the continued development of advanced QM/MM methods for the computational simulation of biological systems and the computational investigation of the structural, functional and dynamical factors of selected proteins of key families involved in DNA maintenance, repair and modification.

PI_NAMEs: CISNEROS, GERARDO ANDRES (contact)

PROJECT_TERMS: Advanced Development;Affect;alpha ketoglutarate;biological systems;Computer Simulation;Computer software;Computing Methodologies;Development;Disease;Distal;DNA;DNA biosynthesis;DNA Maintenance;DNA Modification Process;DNA-Directed DNA Polymerase;Endogenous Factors;Environment;enzyme mechanism;Enzymes;Exogenous Factors;Family;Genome;Goals;Hybrids;improved;inhibitor;Investigation;Iron;Knowledge;Machine Learning;Maintenance;Methods;Modification;molecular dynamics;molecular mechanics;Mutation;programs;Protein Biosynthesis;Proteins;Quantum Mechanics;Reaction;repaired;Sampling;simulation;Structure;Techniques;Therapeutic;tool

PROJECT_TITLE: Computational Simulations of DNA Transaction Enzymes - Application and  Development


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: RICHMOND

ORG_DEPT: PHARMACOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE The interwoven opioid and HIV epidemics have been linked to opioid exacerbation of inflammation and pathology within the central nervous system (CNS), an increased likelihood of opioid use disorder, and cognitive and behavioral deficits. µ-opioid receptors (MORs) are critical in opioid and neuroHIV co-exposure; but the convergence point of synergistic opioid and HIV neuroinflammation and pathology, and their effects in the particularly vulnerable striatum (critical for motivation and reward) are poorly understood. The goal of this study is to identify the role of CNS cell-specific MOR activation in mediating opioid and HIV-induced neuroinflammation and pathology, and whether targeting these mechanisms can rescue resultant neuronal damage and associated behavioral deficits.

PI_NAMEs: NASS, SARA  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Address;Affect;antiretroviral therapy;Astrocytes;Attenuated;attenuation;awake;Award;Behavior;Behavioral;Biological Assay;Buffers;Calcium;career development;Career Mobility;CCL2 gene;CCR5 gene;cell type;Cells;Central Nervous System;Cerebrospinal Fluid;chemokine;Chemosensitization;Coculture Techniques;Cognitive;Cognitive deficits;comorbidity;Corpus striatum structure;Data;Dependovirus;Disease;drug reward;Emotional;Epidemic;Etiology;Event;excitotoxicity;experience;experimental study;Feedback;Female;Fluorescence;Functional disorder;Future;Glial Fibrillary Acidic Protein;Glutamates;Goals;HIV;HIV tat Protein;HIV-associated neurocognitive disorder;Homeostasis;Image;improved;In Vitro;in vivo;in vivo calcium imaging;Inflammation;Inflammatory;Injecting drug user;Injury;insight;Knock-out;Knockout Mice;life span;Link;male;Measures;Mediating;Mentors;Microglia;Morphine;morphine administration;Morphology;Motivation;mu opioid receptors;multiplex assay;Mus;Nerve Degeneration;neuroAIDS;Neuroglia;neuroinflammation;Neuronal Dysfunction;Neuronal Injury;neuronal survival;Neurons;Neuropathogenesis;neuropathology;Neuropathy;neurotoxic;neurotoxicity;Neurovirology;Nitrogen;Opioid;Opioid Analgesics;opioid epidemic;opioid misuse;Opioid Receptor;opioid use;opioid use disorder;Outcome;Oxygen;Pain management;Pathogenesis;Pathologic;Pathology;Persons;Pharmaceutical Preparations;Phase;Play;prescription opioid;Prevalence;prevent;Production;programs;Quality of life;RANTES;reinforcer;Research;response;reward circuitry;Rewards;Risk;Role;Signal Transduction;substance misuse;Sucrose;targeted treatment;Therapeutic Intervention;therapeutic target;Training;United States;Viral;Viral Load result;Viral Proteins

PROJECT_TITLE: The influence of astroglial mu opioid receptors in opioid potentiation of HIV neuropathogenesis

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-K]


NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative: The proposed research is relevant to public health as we will use innovative approaches that probe the spatial organization of cells at unprecedented quantitative detail to uncover novel mechanisms by which the spatial organization of sub-cellular organelles and the genome impacts organelle and gene function under physiological and pathological conditions. The project is relevant to NIH's mission as it will open new horizons for studying how cellular homeostasis is disrupted in diseased cells.

PI_NAMEs: LAKADAMYALI, MELIKE  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Adaptor Signaling Protein;Address;Area;Biochemical Reaction;Biological;Cell Nucleus;Cell Physiology;Cells;Cellular Membrane;Chromatin;Chromatin Fiber;Chromatin Structure;Cytoplasm;Cytoskeleton;Cytosol;Disease;Ensure;Epigenetic Process;Filament;gene function;Genes;Genome;Goals;Health;Homeostasis;In Situ;Individual;innovation;insight;Length;Link;Lysosomes;Maps;Membrane;method development;Methods;Microscopy;Microtubules;Mission;Modification;Molecular;molecular assembly/self assembly;molecular scale;Motor;nanoscale;nanotechnology platform;novel;Nucleic Acids;Organelles;Pathologic;Pathology;Physiological;Positioning Attribute;Proteins;Proteome;Public Health;Quantitative Microscopy;Research;Resolution;spatiotemporal;superresolution imaging;superresolution microscopy;tool;United States National Institutes of Health;Visualization

PROJECT_TITLE: Quantitative super-resolution imaging to map the multi-scale functional organization of cells

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]