ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: At the core of heart failure is the inability of the adult human heart to regenerate after injury. In contrast to the adult human heart, lower vertebrates and neonatal mammals can regenerate their hearts efficiently. The currently proposal addresses the fundamentals of how oxygenation and mechanical load cooperatively regulate endogenous regeneration in mammalian hearts.

PI_NAMEs: SADEK, HESHAM  (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Address;Adult;Birth;Cardiac;Cardiac Myocytes;cardiac regeneration;Cell Cycle Arrest;Cell Cycle Regulation;Cell Therapy;cell type;Clinical Research;Competence;Death Rate;Disease;Future;Heart;Heart failure;Injury;Malignant Neoplasms;Mammals;mechanical load;Mediating;Metabolic;Myocardial;Myocardium;Natural regeneration;Neonatal;Newborn Infant;Organ;Oxygen;postmitotic;postnatal;programs;Proliferating;regeneration potential;regenerative;Regenerative capacity;Regulation;repaired;restoration;Systolic heart failure;Therapeutic;Therapeutic Intervention;Vertebrates;Workload

PROJECT_TITLE: Supply and Demand: Oxygen and Workload Regulate Cardiomyocyte Proliferation


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE There is a critical need to both improve the quality of harmonized data for cross-national research on Alzheimer’s disease and related dementias (ADRD), and better characterize the key drivers of cognitive health within and between populations. We will estimate the contributions of socioeconomic and cardiovascular ADRD risk factors to older adults’ cognitive health across countries, using statistically harmonized data from the Harmonized Cognitive Assessment Protocols (HCAP) in the US Health and Retirement Study (HRS) and its International Partner Studies (IPS) in South Africa, Mexico, India, and England. Our results will set the stage to identify intervention targets for high-risk individuals as well as whole populations, with the ultimate goal of preventing and/or delaying the onset of ADRD from a global perspective.

PI_NAMEs: GROSS, ALDEN L.;KOBAYASHI, LINDSAY C (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Accounting;Address;Aging;Alzheimer's disease related dementia;Alzheimer's disease risk;cardiovascular risk factor;Cardiovascular system;Cognitive;Cognitive aging;cognitive function;cognitive testing;Collaborations;comparative;Consumption;Country;Data;Data Analyses;data harmonization;Dementia;dementia burden;dementia risk;Detection;Documentation;Education;England;evidence base;Funding;Goals;Health;Health and Retirement Study;high risk population;Household;Hypertension;improved;Income;India;Individual;innovation;International;Intervention;late life;Leadership;Life;Life Cycle Stages;low and middle-income countries;Measurement;Measures;men;Methods;Mexico;middle age;Modernization;multilevel analysis;Non-Insulin-Dependent Diabetes Mellitus;Occupations;older adult;Older Population;Outcome;Parents;Population;prevent;Prevention strategy;Productivity;Protocols documentation;Psychometrics;Recording of previous events;Research;Research Personnel;response;Role;social;socioeconomic disparity;Socioeconomic Factors;Socioeconomic Status;socioeconomics;Source;South Africa;Stroke;Structure;Surveys;Testing;theories;Time;Variant;web site;Woman;Work

PROJECT_TITLE: Socioeconomic and Cardiovascular Sources of Cross-National Variation in Cognitive Health Among Older Adults

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE The first few months of HIV infection are characterized by elevated infectiousness, resulting in a disproportionate contribution to population-level HIV spread. This project aims to increase understanding of epidemiological, spatial, and phylogenetic aspects of HIV transmission during early HIV infection, and to estimate the population-level impact of tailored interventions against transmission during this period. Findings will inform future HIV prevention strategies that recognize the importance of addressing early HIV infection in efforts to end the HIV epidemic.

PI_NAMEs: BELL, GRIFFIN  (contact)

PROGRAM_OFFICER_NAME: SHARMA, USHA K

PROJECT_TERMS: Acute;acute infection;Address;Africa;Africa South of the Sahara;AIDS prevention;antigen test;Behavior;Characteristics;Chronic;chronic infection;Client;Clinic;cohort;combat;Communication;Communities;Data;demographics;Detection;Development;Epidemic;Epidemiology;Event;Future;Genetic;Geography;HIV;HIV Infections;HIV Seronegativity;Household;Incidence;Individual;Infection;insight;Intervention;Investigation;Link;Malawi;Manuscripts;mathematical model;member;Mentorship;Modeling;Neighborhoods;novel;Partner Notification;Patients;Persons;Phase;Phylogenetic Analysis;Population;prevent;Prevention;Prevention program;Prevention strategy;Program Efficiency;programs;Questionnaires;Random Allocation;Research;Research Personnel;residence;RNA;screening;seroconversion;Sexual Partners;Sexually Transmitted Diseases;skills;social contact;spatiotemporal;Study models;Testing;Training;transmission process;Trees;Viral;Viral Load result;Virion;Work;Writing

PROJECT_TITLE: Epidemiological, Geospatial, and Phylogenetic Evidence to Inform Interventions Against HIV Transmission during Acute and Early HIV Infection in Lilongwe, Malawi


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Human Genome;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW HAVEN

ORG_DEPT: PEDIATRICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Congenital heart disease affects 1% of all liveborn infants, and is the most common major birth defect. Cilia are antenna-like structures that extend from almost all cells to obtain and interpret information from the extracellular environment, and abnormal cilia are known to cause congenital heart disease. This proposal investigates how cilia instruct normal heart development, and how abnormal cilia can impact patients with CHD.

PI_NAMEs: BRUECKNER, MARTINA  (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: Address;Adult;Affect;Biological;Candidate Disease Gene;Cardiac;cardiogenesis;Cells;chromatin remodeling;Cilia;Clinical;Clinical Research;cohort;comorbidity;Congenital Abnormality;congenital heart abnormality;Contracts;Data;Development;Embryo;Environment;Epigenetic Process;Etiology;experimental study;extracellular;Functional disorder;Genes;Genetic;Genetic Transcription;genomic data;Genomics;Goals;Heart;Heart Diseases;Heart Valves;Histone H2B;Human;human induced pluripotent stem cells;improved;induced pluripotent stem cell derived cardiomyocytes;Infant;Lead;Left;Link;live cell imaging;mechanical drive;mechanical force;Molecular;Monoubiquitination;Morphogenesis;mouse development;Mus;Mutation;optogenetics;Organ;Outcome;Patients;Pediatric Cardiac Genomics Consortium;personalized medicine;Public Health;Research Personnel;Role;Signal Transduction;single-cell RNA sequencing;Specific qualifier value;Structure;Testing;Translating;Work;Zebrafish;zebrafish development

PROJECT_TITLE: Cilia in Heart Development and Disease


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: PROJECT NARRATIVE The proposed research is relevant to public health and supports the NIH’s mission because the results will lead to identification and validation of new targets that are specific for small cell lung cancer, an NCI-designated recalcitrant cancer for which new therapies are urgently needed. At the same time it will identify chemical compounds that will serve as starting points for future dedicated drug discovery projects for these targets and thus lead to therapeutics that contribute to improving survival benefits for this greatly underserved patient population.

PI_NAMEs: MONASTYRSKYI, ANDRII ;RIX, UWE  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Accounting;Affinity;Alkynes;analog;Apoptosis;ASCL1 gene;Azides;BETA2 protein;Binding;Binding Sites;Biochemical;Biological;Biological Assay;cancer cell;Cancer cell line;Cancer Etiology;Cancer Patient;cancer subtypes;cancer therapy;CASP3 gene;Cell Line;Cell Survival;Cells;Cessation of life;Characteristics;chemical association;Chemicals;Chemistry;chemoproteomics;chemotherapy;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Copper;cycloaddition;cytotoxic;Data;Databases;Dedications;Diazomethane;Disease;Dose;driver mutation;Drug Costs;drug development;drug discovery;drug resistance development;Drug Targeting;druggable target;Epithelium;Future;Genetic;IGF1R gene;Immunotherapy;improved;in vivo;Induction of Apoptosis;Informatics;inhibitor;innovation;insight;Knowledge;Lead;Libraries;loss of function mutation;Lung;lung cancer cell;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Mediating;Mining;Minor;Mission;molecular subtypes;Mutate;new therapeutic target;Non-Small-Cell Lung Carcinoma;novel;novel therapeutics;Outcome;patient population;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phenotype;Proteins;Proteomics;Public Health;RB1 gene;Research;response;Risk;RNA Interference;Role;scaffold;screening;Signal Transduction;small cell lung carcinoma;small molecule;standard of care;Structure;success;targeted treatment;Technology;Therapeutic;Time;TP53 gene;transcription factor;Translating;Treatment Failure;Tumor Suppressor Proteins;United States National Institutes of Health;Validation;Western Blotting

PROJECT_TITLE: Integrated fragment-based phenotypic screening and chemoproteomics for identification of novel small cell lung cancer-specific targets


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: St. Louis

ORG_NAME: ST. LOUIS VA MEDICAL CENTER

ORG_STATE: MO

PHR: Multiple myeloma (MM) is the second most common hematological cancer in the U.S and is increasing in frequency, especially among veterans. Although new treatments are available, MM remains incurable. We generated a human natural killer (NK) cell line NK3.3, that releases small membrane-bound extracellular vesicles (EVs) with strong tumor killing activity, without harming normal cells. They also kill drug-resistant and cancer stem cells which are responsible for disease recurrence. Our goal is to develop NK3.3 EVs as a new treatment for MM. We generated a murine xenograft model of minimal residual disease in MM to approximate a human clinical situation. This will be used to test the ability of NK3.3 EVs to prevent MM recurrence after chemotherapy. NK3.3-derived EVs may provide all the advantages of NK cell therapy without the challenges of expanding cells and side effects associated with cellular infusions. These studies are the first step towards providing another treatment option for MM patients to prolong their survival and improve their quality of life.

PI_NAMEs: KORNBLUTH, JACKI  (contact)

PROJECT_TERMS: 3-Dimensional;agent orange;Apoptosis;Area;Binding;Biodistribution;Biological Assay;bioluminescence imaging;Black American;Blood Cells;Blood Chemical Analysis;Body Weight;bone;Bone Marrow;Bone Pain;Bortezomib;cancer cell;cancer stem cell;cancer therapy;Caspase;cell killing;Cell Line;Cell Therapy;Cells;Characteristics;Chemicals;Chemoresistance;chemotherapy;Clinical;clinical development;Clinical Trials;cohort;cytokine release syndrome;Cytolysis;Development;Diagnosis;Disease;Disease remission;Dose;Drug resistance;extracellular vesicles;Fibroblasts;Fracture;Freezing;Frequencies;Genes;Goals;Half-Life;Hematologic Neoplasms;Herbicides;Human;hydrogel scaffold;Immunodeficient Mouse;improved;In Vitro;in vivo;in vivo evaluation;Infiltration;Infusion procedures;innovation;Intravenous;intravenous administration;intravenous injection;kidney dysfunction;kidney infection;knock-down;Label;Laboratories;lenalidomide;Lesion;lipidomics;loss of function;Lytic Metastatic Lesion;Maintenance Therapy;Mediating;Membrane;Modeling;Molecular;Monitor;mouse model;Multiple Myeloma;Mus;Natural Killer Cell Immunotherapy;Natural Killer Cells;neoplastic cell;NK cell therapy;Normal Cell;novel therapeutics;Organ Weight;Osteolytic;Pathway interactions;Patients;Penetration;peripheral blood;Peripheral Blood Lymphocyte;Pharmaceutical Preparations;pomalidomide;Preparation;prevent;Primary Neoplasm;Process;Production;Proteomics;Quality of life;Recurrence;Recurrent disease;Recurrent tumor;Refractory;Regimen;Relapse;relapse patients;Residual Neoplasm;Resistance;Risk;Roentgen Rays;Sampling;side effect;Stable Disease;stem cell therapy;stemness;Survival Rate;Testing;Time;Toxic effect;tumor;Tumor Burden;tumor hypoxia;tumor microenvironment;Veterans;Vietnam;Visual;X-Ray Computed Tomography;Xenograft Model

PROJECT_TITLE: Molecular Characterization of Anti-Tumor Activity Mediated by Extracellular Vesicles Derived from Natural Killer Cells


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Disability Research;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Nutrition;Pediatric;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: The proposed research is relevant to public health because there are no strategies to ameliorate the sensory ataxia associated with Angelman syndrome. The PIEZO2 mechanosensitive ion channel is a promising target for decreasing sensory ataxia since it mediates proprioception and balance. The proposed study is relevant to the NIH’s mission because it will provide the molecular basis for understanding the mechanism by which the lack of a ubiquitin-protein ligase modulates sensory neuron mechano-responses in the context of Angelman syndrome.

PI_NAMEs: CORDERO-MORALES, JULIO F (contact);VASQUEZ, VALERIA

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Acids;Actin-Binding Protein;Actins;Action Potentials;Afferent Neurons;Agonist;Alleles;Angelman Syndrome;Animals;Atomic Force Microscopy;Behavior;Behavioral;Biochemical;Biochemistry;Biophysics;Brain;Bypass;Cell membrane;Cells;Chemicals;cofilin;conditional knockout;Cytoskeleton;Data;Diet;Disease;Electrophysiology (science);Endowment;Equilibrium;Evaluation;F-Actin;feeding;Gait;Gait abnormality;Genetic Models;Goals;Golgi Tendon Organs;Human;Human Cell Line;Human Genetics;improved;in vivo;Individual;Intellectual functioning disability;Intervention;Ion Channel;knock-down;Knockout Mice;Knowledge;Length;Ligase;Limb structure;Linoleic Acids;lipidomics;Lipids;loss of function;loss of function mutation;Measures;Mechanics;Mediating;Membrane;Microfilaments;Mission;Molecular;motor impairment;mouse model;Movement;Mus;Muscle Spindles;Mutation;neurogenetics;Neurons;optogenetics;paternal imprint;Piezo 2 ion channel;Polyunsaturated Fatty Acids;Positioning Attribute;Posture;Property;Proprioception;Proteins;Public Health;Repression;Research;Role;Safflower Oil;Seizures;Sensory;Sensory Ataxias;Sensory Receptors;Specificity;Spectrin;Spinal Ganglia;stem cells;Supplementation;Testing;UBE3A gene;ubiquitin-protein ligase;United States National Institutes of Health;Unsteady Gait;walker;Walking;Wheelchairs;Work

PROJECT_TITLE: The Role of Sensory Receptors in Angelman Syndrome

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: SEATTLE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Given the lack of effective disease-modifying therapies for Alzheimer’s disease (AD), it is imperative to further explore alternative disease-relevant pathways, including those involving tau and TDP-43. Although more recently recognized as relevant to the pathology of late-onset AD, there is evidence from human cohorts that TDP-43 is highly prevalent in aging populations, significantly increases the risk for cognitive decline, and is associated with pathologic tau, but the underlying mechanism is unknown. I propose to elucidate the mechanisms underlying the synergism between TDP-43 and tau by integrating C. elegans as an experimental model of combined proteotoxicity with human neuropathologic and gene expression data, and in doing so determine whether targeting pathways that underlie this relationship will more effectively rescue the disease phenotype than targeting either alone.

PI_NAMEs: LATIMER, CAITLIN SHANNON (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Adult;age related;Aging;Algorithms;Alzheimer's Disease;Alzheimer's disease therapeutic;Alzheimer's disease therapy;Area;Autopsy;Behavioral;Biological;Biological Models;Brain;Brain region;brain tissue;Caenorhabditis elegans;Calcineurin;Candidate Disease Gene;candidate validation;career;CDC7 gene;Classification;Clinical;cohort;Cohort Studies;Communities;Coupled;Data;Dementia;Development;digital imaging;Disease;disease phenotype;DNA-Binding Proteins;Experimental Models;follow-up;Foundations;Freezing;Functional disorder;Funding;Future;Gene Expression;Gene Modified;Generations;Genes;Genetic;Genetic Transcription;Goals;hippocampal atrophy;Hippocampus;Homologous Gene;Human;Human Characteristics;human data;human disease;Human Genetics;Human Pathology;human RNA sequencing;human tissue;hyperphosphorylated tau;Image Analysis;Immunohistochemistry;Impaired cognition;in vivo;Instruction;Knowledge;Late Onset Alzheimer Disease;Life Cycle Stages;Link;loss of function;Measures;Mentors;Mentorship;Modeling;Molecular;multidisciplinary;mutant;Nerve Degeneration;neuropathology;neurotoxic;neurotoxicity;new therapeutic target;novel;older adult;Pathologic;Pathology;Pathway Analysis;Pathway interactions;Phenotype;Phosphorylation;Physicians;Population;progressive neurodegeneration;protective effect;protein aggregation;protein TDP-43;Proteins;proteotoxicity;recruit;Research;Research Personnel;Research Technics;response;Risk;Role;Sampling;Scanning;Scientist;skills;synergism;System;tau Proteins;Techniques;Testing;Tissue Sample;Tissues;Training;transcriptome sequencing;transcriptomics;Transgenic Organisms;Validation;Work

PROJECT_TITLE: Molecular Mechanisms of Synergistic TDP-43 and Tau Proteotoxicity in Alzheimer's Disease

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Digestive Diseases - (Peptic Ulcer);Genetics;Infectious Diseases;Rare Diseases;Stomach Cancer

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE Helicobacter pylori infect the human stomach of 50% of the world’s population where it can cause mild inflammation, ulcer disease and even gastric cancer, depending in part on the genetic diversity of the infecting strain. In this project we study the genes and mechanisms contributing to chronic colonization to identify the mediators of persistent infection. Our studies of genetic variation during stomach infection will show how these mediators adapt during the chronic inflammation that leads to severe disease (cancer).

PI_NAMEs: SALAMA, NINA  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Acids;Adenocarcinoma;Adoptive Transfer;Animals;Atrophic Gastritis;Attenuated;Bone Marrow;carcinogenesis;cell envelope;Cell Shape;Cells;chemokine;Chemotaxis;Chronic;chronic infection;Clinical;Clinical Data;Coculture Techniques;Collection;Data;Disease;Environment;Epithelial Cells;Epithelium;Event;Excision;Flow Cytometry;Funding;Gastric Adenocarcinoma;Gastric Metaplasia;Gastric mucosa;gastric organoids;Gastric Parietal Cells;Gene Expression;Genes;Genetic;genetic analysis;Genetic Recombination;Genetic study;Genetic Transcription;genetic variant;Genetic Variation;Helicobacter Infections;Helicobacter pylori;Helicobacter pylori induced carcinogenesis;Host Defense;Human;Immune;immune activation;immunoregulation;In Vitro;in vivo;Individual;Infection;Infiltration;Inflammation;Inflammatory;Intestinal Intraepithelial Neoplasia;Intestinal Metaplasia;Leukocytes;Lymphoid Tissue;Malignant Neoplasms;malignant stomach neoplasm;Mediating;Mediator;Membrane Proteins;Metaplasia;Modeling;Molecular;Monitor;Motility;mouse model;Mus;mutant;Mutation;Myelogenous;Myeloid Cells;neoplastic;neutrophil;novel;Organism;pathogen;Pathogenicity;Pathology;Peptic Ulcer;Phenotype;Population;population based;receptor;recruit;response;Risk;Role;Sampling;Sequence Analysis;Signal Pathway;Signal Transduction;spasmolytic polypeptide;Stomach;System;Testing;Tissues;Toxin;transmission process;tumor-immune system interactions;Type IV Secretion System Pathway;Ulcer;Variant;whole genome;Work

PROJECT_TITLE: Genetic requirements of Helicobacter pylori infection

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Aging;Bioengineering;Dental, Oral, and Craniofacial Disease;Regenerative Medicine

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Class V restorations, dental restorations on the lower third of the tooth, fail at a higher rate than any other class of dental restoration. Our proposed research will engineer a biofunctional sealant that reduces Class V restoration failure by facilitating attachment of gingival tissue to the restoration surface using peptides. This proposal will illuminate oral keratinocyte integrin activation and contribute to the PI’s training and attainment of career goals.

PI_NAMEs: FISCHER, NICHOLAS G (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TITLE: Biofunctional sealant with peptides to extend lifespans of Class V restorations

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative We propose the clinical translation and validation of an innovative “radiofrequency (RF) penetrable” positron emission tomography (PET) insert technology that can be placed within any stand-alone magnetic resonance imaging (MRI) system for acquiring simultaneous PET/MRI data using the MR system’s built-in body coil for RF transmission. If successful, the results of this project will enable more widespread dissemination of and accessibility to simultaneous PET/MR imaging through the availability of this lower cost, novel PET insert technology alternative to the high cost permanently integrated PET/MR systems that are currently deployed in the field.

PI_NAMEs: LEVIN, CRAIG S (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TERMS: Address;Adherence;Adoption;Agreement;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid;Anatomy;Biological Markers;Brain;Breast;Clinic;Clinical;clinical translation;Coiled Bodies;Collection;comparative;Computer software;computerized data processing;cost;Data;data acquisition;data platform;Data Set;data standards;Dedications;design;Development;Diameter;Digital Imaging and Communications in Medicine;Disease;disease classification;Engineering;Ensure;Exhibits;FDA approved;Generations;graphical user interface;Head;Head and neck structure;Image;image reconstruction;imaging system;Impaired cognition;improved;Industry;Industry Collaboration;industry partner;Industry Standard;innovation;Inpatients;Institution;Ionizing radiation;Liver;Machine Learning;Magnetic Resonance Imaging;Marketing;Measurement;Methods;Modality;Modeling;Modification;Motion;National Institute on Aging;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neuroimaging;new technology;novel;Patients;pediatric patients;Pelvis;Performance;Phase;Photons;Positron-Emission Tomography;Radiation Dose Unit;radio frequency;Recurrence;Research;Resolution;Scanning;soft tissue;software development;Software Validation;Standardization;stem;Study Subject;System;tau aggregation;tau Proteins;Technology;technology validation;Translating;translational study;Translations;transmission process;Validation;Vendor;Work

PROJECT_TITLE: Translation and Validation of a Radiofrequency-Penetrable PET insert for Simultaneous PET/MRI imaging of Neurological Disorders


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative  This project will improve our understanding of how an enzyme, HDAC11, is involved in the development and progression of some immune-mediated diseases such as multiple sclerosis (MS). Additionally, the project will develop and test selective HDAC11 inhibitors as therapeutics and potentially establish a novel treatment strategy for MS. The proposed research is relevant to the NIH’s mission to develop fundamental strategies and knowledge that will improve healthcare and reduce the hardships associated with illnesses and disabilities.

PI_NAMEs: LIN, HENING ;MILLER, ROBERT H.;SETO, EDWARD  (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Acute;acyl group;Adverse effects;Affect;alternative treatment;Autoimmune Diseases;Biochemical;Biological;Biological Process;cell motility;Cells;central nervous system demyelinating disorder;Chemicals;Chronic;Chronic Progressive Multiple Sclerosis;Clinical;Clinical Trials;CNS Demyelinating Autoimmune Diseases;Collaborations;Data;Deacetylase;Deacetylation;design;Development;disability;Disabling;Disease;Disease Management;effective therapy;Enzyme Inhibitor Drugs;Enzymes;Experimental Autoimmune Encephalomyelitis;fatty acylation;Future;Genetic Models;Goals;HDAC11 gene;HDAC4 gene;Health;Healthcare;Histone Deacetylase;Immune;immune cell infiltrate;improved;in vivo;inhibitor;insight;Interferon Type I;Interferons;Knockout Mice;Knowledge;Laboratories;Lysine;Mediating;Mission;Modeling;mouse model;multidisciplinary;Multiple Sclerosis;multiple sclerosis patient;multiple sclerosis treatment;Mus;Nerve Degeneration;Nervous System Disorder;new therapeutic target;novel;novel therapeutic intervention;Pathogenesis;Pathology;Persons;Pharmaceutical Preparations;Phase;Physiological;Proteomics;prototype;Recombinant Interferon Beta;Relapsing-Remitting Multiple Sclerosis;Reporting;Research;Role;Severity of illness;Side;Signal Transduction;small molecule;Spinal Cord;Symptoms;targeted treatment;Testing;Therapeutic;Time;tool;treatment strategy;United States National Institutes of Health;Universities;Virus Diseases;Washington;Work;young adult

PROJECT_TITLE: Design and development of HDAC11-specific chemical inhibitors for disease treatments

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Radiation Oncology;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Narrative The current treatment paradigms for minimally invasive ablative breast cancer therapies do not ensure complete tumor ablation or allow for immediate and accurate assessment of tissue viability. Although several MRI contrasts are sensitive to thermal ablation, no individual or combined MR contrasts have been able to accurately predict tissue viability immediately after magnetic resonance guided focused ultrasound ablation. This proposal will develop a non-contrast, deep neural network imaging biomarker that will provide both an accurate assessment of tissue viability and a treatment outcome metric that will allow for iterative MRgFUS ablation assessment, ensuring efficacy of magnetic resonance guided focused ultrasound ablation treatments for breast cancer.

PI_NAMEs: JOSHI, SARANG ;PAYNE, ALLISON  (contact)

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: 3-Dimensional;Ablation;Address;Advanced Development;Anatomy;Applications Grants;Benchmarking;Biological Markers;Biomedical Engineering;Blood Vessels;Breast;Breast Cancer Patient;Breast Cancer therapy;Breast Cancer Treatment;Breast Magnetic Resonance Imaging;Cancer Center;Clinical;Clinical assessments;Clinical Trials;Collaborations;Computer Vision Systems;Contrast Media;convolutional neural network;Cosmetics;Data;Data Set;deep learning;deep neural network;detection method;Development;Diagnosis;digital imaging;Dose;Early Diagnosis;efficacious treatment;Ensure;Environment;Female;Focused Ultrasound;Focused Ultrasound Therapy;Future;Gadolinium;Goat;Histopathology;Image;Image Analysis;image registration;imaging biomarker;improved;in vivo;Individual;innovation;International;Label;Literature;Magnetic Resonance;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Methods;minimally invasive;model design;Modeling;Monitor;mortality;multidisciplinary;novel;Oryctolagus cuniculus;overtreatment;Pathology;patient population;Patients;Pre-Clinical Model;predictive marker;Procedures;professional atmosphere;Protocols documentation;radio frequency;Radiology Specialty;reconstruction;Research Project Grants;Research Proposals;Safety;System;Techniques;Therapeutic;Thermal Ablation Therapy;Thermometry;Time;Tissue Viability;Tissues;Training;Translations;Treatment Efficacy;Treatment outcome;treatment planning;treatment response;tumor;tumor ablation;Udders;Validation;Work

PROJECT_TITLE: A tissue viability imaging biomarker for use in non-invasive breast cancer therapy

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Osteoarthritis

ORG_CITY: BOSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: TUFTS UNIVERSITY BOSTON

ORG_STATE: MA

PHR: Narrative Osteoarthritis (OA) is a highly prevalent degenerative joint disease that poses a huge economic burden to our society. Currently, there is still a lack of clear understanding on how OA develops and why certain individuals are more prone to OA damage; as a result, there is no optimal treatment to stop its progression. Our proposal investigates the novel role of a protein (Wnt7a) in halting the trajectory of OA and predicting the severity of joint destruction, thus providing new insights into treating OA on an individual basis.

PI_NAMEs: ZENG, LI  (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Aging;articular cartilage;Automobile Driving;Bioluminescence;Cartilage;Cartilage Matrix;Chondrocytes;Competence;competence factor;conditional knockout;cytokine;Data;Degenerative polyarthritis;design;Disease;Disease Progression;Dose;Economic Burden;Ectopic Expression;effective therapy;Equilibrium;Family;Fluorescence;gain of function;GDF5 gene;Generations;Genes;Goals;Grant;Heterogeneity;high risk;Human;Imaging technology;immune cell infiltrate;improved;Individual;individual response;Inflammation;Inflammatory;insight;Interleukin-1 beta;joint destruction;joint injury;Joints;Link;loss of function;Maintenance;Matrix Metalloproteinases;Medial meniscus structure;Mediating;Messenger RNA;microCT;Modeling;Molecular Profiling;Mus;novel;nuclear factors of activated T-cells;optimal treatments;Pain;Pathogenesis;Pathway interactions;Persons;Population;Population Sizes;preservation;Proteins;receptor;Regulation;Resistance;Resolution;response;Risk Factors;Role;Sampling;second harmonic;Severities;Signal Transduction;Societies;Specimen;stem;Stimulus;Technology;Testing;Time;Tissues;WNT Signaling Pathway;Work;X-Ray Computed Tomography

PROJECT_TITLE: Wnt7a-Mediated Competence to Resist Osteoarthritis Progression

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Nutrition;Obesity

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative: The synthesis of lipids in our bodies is essential for normal metabolism but is abnormal in diseases like obesity, diabetes, cardiovascular disease, cancer, neurodegeneration and infection. Mitochondria are subcellular organisms known for oxidizing lipids, but they also have a less understood role in synthesizing lipids. This project investigates how mitochondria contribute lipid synthesis, with the goal of better understanding how disease disrupts the normal regulation of lipid metabolism.

PI_NAMEs: BURGESS, SHAWN C (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Acetyl Coenzyme A;Analytical Chemistry;Carbohydrates;Cardiovascular Diseases;Charge;citrate carrier;Citrates;Citric Acid Cycle;Complement;Consumption;Cytosol;Data;Diabetes Mellitus;Diet;Disease;Dyslipidemias;Equilibrium;Esterification;experimental study;Fasting;feeding;Gene Expression;Genes;Genetic Transcription;Gluconeogenesis;Goals;Hormones;Impairment;in vivo;Infection;Knockout Mice;Link;lipid biosynthesis;lipid mediator;lipid metabolism;Lipids;Liver;loss of function;Malates;malic enzyme;Malignant Neoplasms;Malonyl Coenzyme A;Mediating;Metabolic;Metabolism;metabolomics;Mitochondria;Modeling;mouse genetics;Mus;NADP;Nerve Degeneration;nutrition;Obesity;Organism;Oxaloacetates;Oxidation-Reduction;oxidized lipid;Pathologic;Pathway interactions;permissiveness;Phosphoenolpyruvate Carboxylase;Phosphorylation;Physiology;programs;Pyruvate;Pyruvate Carboxylase;Reaction;Regulation;response;Role;Source;stable isotope;Sucrose;Testing;Tracer;Transcriptional Regulation

PROJECT_TITLE: Regulation of lipogenesis by TCA cycle metabolism

STUDY_SECTION: IPOD

STUDY_SECTION_NAME: Integrative Physiology of Obesity and Diabetes Study Section[IPOD]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Project Narrative Over 90% of people with Parkinson’s disease have speech problems that significantly reduce their quality of life. However, the relative contributions of changes in speech physiology to outcomes that matter to patients are unknown. This knowledge is crucial for providing patients with realistic expectations and interventions that pin- point appropriate physiological targets in therapy. The results of this project will allow clinicians to target specific speech subsystems most likely to improve outcomes that matter to patients based on physiological or acoustic evaluation.

PI_NAMEs: MEHTA, DARYUSH DINYAR;STEPP, CARA E. (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acoustics;Address;Affect;Air Movements;algorithm development;Articulation;base;Behavioral;Characteristics;clear speech;Clinical;clinical decision-making;clinical translation;Clinical Trials;clinically actionable;Cognition;Cues;Data;Development;Disease;Disease Progression;Electromagnetics;Evaluation;Evidence based treatment;expectation;experience;Future;Goals;Heterogeneity;Impairment;improved;improved outcome;Individual;instrumentation;Intervention;kinematics;Knowledge;knowledge translation;Language;Larynx;Life;Link;Longitudinal Studies;Measures;Mental Depression;Methods;Neurologic;novel;older adult;Oral;Outcome;Outcome Measure;Parkinson Disease;Patient-Focused Outcomes;Patients;personalized medicine;Persons;Physiological;Physiology;Predictive Value;pressure;Production;Progressive Disease;Psychometrics;Quality of life;Rehabilitation therapy;Research;Resources;respiratory;Sampling;Specificity;Speech;Speech Acoustics;Speech Disorders;Speech Intelligibility;Speech Therapy;Symptoms;Testing;therapeutic target;Time;Visit;wasting;Work

PROJECT_TITLE: Comprehensive assessment of speech physiology and acoustics in Parkinson's disease progression


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lung;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Pulmonary Fibrosis;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: NARRATIVE Following acute infection with SARS-Cov2 persistent symptoms of fatigue and shortness of breath are common, with physiologic, functional and quality of life impairments lasting up to 6 months or more. Little is known about the causes and long-term effects of these post-COVID, or “long COVID” syndromes. Our longitudinal studies will evaluate progressive pulmonary and neurocognitive dysfunction following acute COVID-19 infection, assessing host genetic and etiologic causes that will enable the development of future treatments.

PI_NAMEs: ABRAMSON, STEVEN B (contact);CONDOS, RANY

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: 2019-nCoV;Acute;acute COVID-19;Acute Disease;acute infection;Affect;Antibodies;Antibody Response;Autoantibodies;Autoimmune;Autoimmune Process;Automobile Driving;Biological Markers;black patient;Black race;breakthrough infection;Carbon Monoxide;Categories;Characteristics;Chronic;Clinical;Clinical Data;cognitive testing;cohort;COVID-19 patient;COVID-19 sequelae;cytokine;Data;deprivation;design;Development;Diffusion;Disease;Ethnic Origin;Etiology;Fatigue;Feces;Frequencies;Functional disorder;Future;Genetic;genetic association;Genetic Polymorphism;Genetic Predisposition to Disease;Genetic Processes;Genetic Risk;Genetic Variation;Genotype;Goals;health disparity;idiopathic pulmonary fibrosis;Immune response;Immunologics;immunoregulation;Impairment;Incidence;indexing;Infection;Infection Control;Inflammatory;Inflammatory Response;Interferons;Interleukin-1;Long COVID;long term consequences of COVID-19;Long-Term Effects;Longitudinal Studies;Lung;Lung CAT Scan;Measures;Minority Groups;Nasopharynx;Neighborhoods;Neurocognitive;novel;Outcome;Pathogenicity;Pathway interactions;Patient Outcomes Assessments;patient stratification;Patients;persistent symptom;Phenotype;Physiological;Play;post COVID-19 complications;post SARS-CoV-2 infection;Post-Acute Sequelae of SARS-CoV-2 Infection;post-COVID-19;primary endpoint;Process;Protocols documentation;Proxy;Pulmonary Fibrosis;pulmonary function;pulmonary symptom;Pulse Oximetry;Quality of life;Questionnaires;Race;Recording of previous events;risk variant;RNA;Role;SARS-CoV-2 infection;secondary outcome;Severities;Shortness of Breath;social determinants;social health determinants;Social outcome;Socioeconomic Status;Symptoms;Syndrome;Telephone;Testing;therapeutic target;Tissues;Total Lung Capacity;United States Agency for Healthcare Research and Quality;Vaccination;Vital capacity;Walking;X-Ray Computed Tomography

PROJECT_TITLE: Genetic and Immuno-inflammatory Drivers of Post-acute Pulmonary Sequelae of SARS-CoV-2

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Estrogen;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

PHR: Project Narrative Recurrence is a significant and unsolved clinical problem for patients with estrogen receptor alpha (ER)- positive luminal breast cancers. We propose that, in ER+ breast cancer, phosphorylated progesterone receptors (p-PRs) interact with ER and ER target genes and also have functions distinct from ER that together, drive resistance to endocrine therapy and the development of cancer stem cells that lead to late recurrence. Our studies will elucidate the mechanisms of p-PR actions in ER+ breast cancer and will identify new drug targets and drug combinations for preventing and treating recurrences.

PI_NAMEs: LANGE, CAROL A (contact);SARTORIUS, CAROL ANN

PROGRAM_OFFICER_NAME: HILDESHEIM, JEFFREY

PROJECT_TERMS: Ablation;Adaptor Signaling Protein;Address;Adrenergic alpha-Antagonists;advanced disease;Advanced Malignant Neoplasm;Anti-estrogen Therapy;Anti-Progestin;Binding;Binding Proteins;Biological Markers;Breast Cancer Cell;Breast Cancer Patient;breast cancer progression;Breast Cancer Treatment;cancer biomarkers;cancer cell;cancer recurrence;cancer stem cell;Cell Proliferation;Cells;ChIP-seq;Clinical;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;Cytoplasm;Darkness;Development;Disease;Disease Progression;disorder control;Distant Metastasis;Drug Combinations;Economic Burden;Endocrine;ESR1 gene;Estrogen Antagonists;Estrogen receptor positive;Event;experience;Failure;FOXO1A gene;Gene Expression;gene product;Genes;Genetic Transcription;Gonadal Steroid Hormones;Growth;Growth Factor;Growth Factor Receptors;high risk;hormone sensitivity;hormone therapy;Hormones;Human;improved;improved outcome;In Vitro;in vivo;inhibitor;Insulin Receptor;insulin sensitivity;Knock-in;Length;Ligands;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammary Neoplasms;MAP Kinase Gene;Mass Spectrum Analysis;Mediating;Messenger RNA;Metastatic/Recurrent;Modeling;mortality;Mus;Neoplasm Metastasis;new therapeutic target;Normal tissue morphology;novel;Oncogenic;Organoids;Outcome;overexpression;patient derived xenograft model;Patient-Focused Outcomes;Patients;Phenotype;Phosphorylation;Population Biology;Positive Lymph Node;Postmenopause;prevent;Primary Neoplasm;progenitor;progesterone receptor A;progesterone receptor B;Progesterone Receptors;programs;Proliferating;Protein Isoforms;receptor;Receptor Gene;Receptor Signaling;Recurrence;Regulation;Research Support;Resistance;response;Role;sensor;Side;Signal Pathway;Signal Transduction;Social Network;stem;stem cell population;Tamoxifen;targeted treatment;Testing;therapeutic target;Time;transcriptome sequencing;treatment response;tumor;tumor growth;tumor microenvironment;tumor progression;Woman;Work

PROJECT_TITLE: Progesterone Receptor (PR) Signaling Cross Talk Drives ER+ Breast Cancer

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dietary Supplements;Nutrition;Prevention;Urologic Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative  The  role  of  vitamin  C  in  calcium  oxalate  stone  disease  is  unclear.  It  is  known  to  be  converted  in  the  body  to  oxalate, an important contributor to this disease, but the factors that influence this process are not known. The  studies  proposed  will  use  diets  of  known  nutrient  composition  and  mass  spectrometric  techniques  to  define  vitamin C contribution to oxalate in human volunteers, experimental animals and cultured cells.

PI_NAMEs: KNIGHT, JOHN  (contact)

PROGRAM_OFFICER_NAME: KIRKALI, ZIYA

PROJECT_TERMS: absorption;Acceleration;Adult;Affect;Animal Experiments;Animal Model;Antioxidants;Ascorbic Acid;Attenuated;Biological Models;Calcium;Calcium Oxalate;Carbon;Cell Line;Cell model;Chromatography;Consumption;Coupled;Cultured Cells;Cysteine;defined contribution;Detection;Diet;dietary;dietary control;Dietary intake;Disease;Dose;epidemiology study;Excretory function;experimental study;Female;Food;Generations;Glutathione;Gulo;Health Care Costs;Human;human subject;Human Volunteers;Ingestion;Intake;Intravenous;Investigation;Ions;Kidney;Kidney Calculi;Knockout Mice;Label;male;Measurement;Measures;Metabolic;Metabolism;Mitochondria;Modeling;mouse model;Mus;neutrophil;Nutrient;Nutritional Study;obese person;Obesity;Oral;Organelles;Oxalates;Oxidants;Oxidative Stress;Plasma;Population;Process;Production;Quality of life;Reactive Oxygen Species;Recommended Daily Allowances;Research;Risk;Risk Factors;Role;Sampling;screening;Small Interfering RNA;Source;stable isotope;Techniques;Testing;Thinness;uptake;urinary;Urine

PROJECT_TITLE: Oxalate formation from ascorbic acid

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-B(90)]


NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Chronic Pain;Neurosciences;Osteoarthritis;Pain Research;Physical Injury - Accidents and Adverse Effects

ORG_CITY: CHICAGO

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: Project Narrative Osteoarthritis is a common disease and a major source of chronic pain, yet treatment options are limited. This project seeks to understand how the response of cells in the knee joint to mechanical loading changes in osteoarthritis and how that may contribute to the disease. A better understanding of this process may yield new therapeutic targets for treating osteoarthritis.

PI_NAMEs: MILLER, RACHEL ELIZABETH (contact)

PROJECT_TERMS: Action Potentials;Acute;Acute inflammatory pain;Address;Affect;Afferent Neurons;Arthralgia;Attenuated;Behavior;Biomechanics;Calcium;Cartilage;Cell Physiology;Cells;Chondrocytes;Chronic Disease;chronic pain;conditional knockout;Data;Degenerative polyarthritis;Development;Disease;Disease Progression;Femur;Future;Goals;GsMTx-4;Hyperalgesia;Image;Imaging Device;imaging modality;improved;In Situ Hybridization;in vivo;inflammatory pain;innovation;insight;Intra-Articular Injections;Ion Channel;joint injury;Joints;Knee;Knee joint;Knee Osteoarthritis;Knock-out;Knockout Mice;Measures;mechanical allodynia;mechanical drive;mechanical force;mechanical load;mechanical stimulus;Mechanics;Medial meniscus structure;Mediating;Modeling;mouse model;Mus;Nervous System;Neurons;new therapeutic target;Nociceptors;novel;osteoarthritis pain;Pain;pain behavior;painful neuropathy;Pathology;Pathway interactions;Peripheral;Persistent pain;Persons;Piezo 1 ion channel;Piezo 2 ion channel;Piezo ion channels;Play;Population;Process;Proteins;Reporter;Reporting;response;Roentgen Rays;Role;Signal Transduction;small molecule inhibitor;Source;targeted treatment;Techniques;Testing;Therapeutic;therapeutic evaluation;Time;Tissues;tool;Up-Regulation;voltage;Weight-Bearing state;Work

PROJECT_TITLE: The Role of Mechanosensation Pathways in Osteoarthritis Joint Damage and Pain


PHR: Project Narrative Target-occupancy studies using PET are critical for go/no-go decisions in CNS drug development. We have developed an algorithm that provides superior, high resolution functional images as endpoints that are less susceptible to bias. They can detect drug action in local brain regions of greatest therapeutic importance. Our academic-industrial partnership with Invicro, LLC – a leading provider of target-occupancy studies to pharmaceutical companies –will help us to validate our invention and to assure that it is disseminated to end- users.

PI_NAMEs: MORRIS, EVAN D (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Adopted;Affinity;Algorithms;archived data;Binding;Binding Sites;Biological;Brain;Brain imaging;Brain region;Characteristics;Collaborations;cost;Data;Databases;Dependence;design;Development;Dose;drug action;drug candidate;drug development;drug discovery;Drug Industry;Drug Targeting;drug testing;Enzymes;experience;experimental study;Functional Imaging;Goals;Human;Image;image registration;in vivo;in vivo imaging system;Individual;Industrialization;industry partner;innovation;interest;Intervention;invention;Knowledge;Location;Manuals;Measures;Methods;Noise;nonhuman primate;novel;novel therapeutics;Outcome;Output;Performance;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Positioning Attribute;Positron-Emission Tomography;practical application;Predisposition;Primates;Provider;receptor;Research;Research Design;Resolution;Resources;response;simulation;Site;skills;Spatial Distribution;Speed;standard measure;Statistical Methods;Target Populations;Technology;Testing;Therapeutic;Tracer;Translating;Translations;uptake;Validation;Variant;Work

PROJECT_TITLE: Validation of Occupancy Images from PET Data. A Novel Endpoint for Drug Discovery


NIH_SPENDING_CATS: Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: NEUROLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: We will perform a systemic study that integrates multiple genetic mutant lines of mice, human induced neuron lines, quantitative proteomics, molecular and cell biology to identify autophagy cargo and receptors in neurons and microglia. Our study will pave the way to identify novel therapeutic targets of autophagy in the treatment of  neurodegenerative diseases.

PI_NAMEs: YUE, ZHENYU  (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: A kinase anchoring protein;Adult;Age;age related;age related neurodegeneration;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's Disease Pathway;Amyotrophic Lateral Sclerosis;Animal Model;Autophagocytosis;Autophagosome;Axon;Behavioral;Brain;Catabolic Process;Cell model;cell type;Cells;Cellular biology;Complex;Cyclic AMP-Dependent Protein Kinases;Disease;dopaminergic neuron;Funding;Genetic;Genetic study;Goals;Homeostasis;Human;Huntington Disease;Induced Neurons;insight;Knock-out;Knowledge;Lysosomes;Maintenance;Maps;Mediating;Microglia;Midbrain structure;Molecular;Molecular Biology;Mus;mutant;Mutant Strains Mice;Neurodegenerative Disorders;neuromelanin;Neurons;neuropathology;neuroprotection;new therapeutic target;novel;Organelles;Parkinson Disease;Pathogenicity;Pathologic;Pathway interactions;Phosphotransferases;Physiological;prevent;protein aggregation;protein degradation;Proteins;Proteomics;Quality Control;receptor;Recycling;Regulation;Reporting;Role;Synaptic Vesicles;SYNJ1 gene;synucleinopathy;Therapeutic;trafficking;Validation

PROJECT_TITLE: Neuronal Autophagy: a Cell-Autonomous Protection Mechanism

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ORG_CITY: SAINT LOUIS

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE  The goals of this new research education program are to introduce outstanding predoctoral medical students to the excitement and challenges of research to stimulate an interest in research as part of their future career goals and to train postdoctoral otolaryngology resident-investigators in the tools and techniques of research so that they may compete successfully for individual NIH-sponsored research awards and eventually assume leadership roles in academic medicine. The successful completion of these goals will result in increased numbers of diverse, well- trained physician-scientists who will lead multidisciplinary research teams addressing complex health problems in the mission areas of NIDCD.

PI_NAMEs: PICCIRILLO, JAY F. (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Address;Adoption;Area;Award;Basic Science;Behavioral Research;career;career development;Clinical;Clinical Research;clinical training;commercialization;Communication impairment;Complex;deafness;Development;digital;Discipline;Disease;dissemination science;Education;education pathway;Education Projects;education research;Educational Curriculum;Educational workshop;effectiveness evaluation;Ensure;Entrepreneurship;Ethnic Population;Evaluation;experience;Faculty;faculty mentor;Fellowship;Foundations;Funding;Future;Goals;Grant;Head and Neck Surgery;Health;Healthcare;implementation science;improved;Individual;innovation;Interdisciplinary Study;interest;Knowledge;laboratory experiment;Laboratory Research;Lead;Leadership;Marketing;medical schools;Medical Students;Medicine;member;Mentors;Mentorship;Methods;Midwestern United States;Mission;National Institute on Deafness and Other Communication Disorders;new technology;Otolaryngology;outreach;Pathway interactions;peer coaching;Physicians;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;pre-doctoral;preservation;programs;racial population;recruit;Reproducibility;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;Research Technics;Research Training;Residencies;response;Role;Scientist;Secure;skill acquisition;success;Techniques;Time;tool;Training;training opportunity;Training Programs;Translational Research;United States National Institutes of Health;Universities;video module;Washington

PROJECT_TITLE: Otolaryngology R25 Mentored Research Pathway at Washington University


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Lymphatic Research;Neurodegenerative;Neurosciences;Pediatric

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative The proposed research is relevant to public health because glaucoma is the leading causes of irreversible blindness worldwide, but its causes and underlying mechanisms are poorly understood. The results of the proposed studies with new cutting edge imaging technologies will significantly contribute to a better understanding of the mechanisms underlying the formation and function of the trabecular meshwork and Schlemm's canal. Thus, the proposal is relevant to the NEI's mission and is likely to lead to the identification of new targets and therapeutic strategies for improving the drainage of aqueous humor from the anterior segment of the eye in affected patients.

PI_NAMEs: KUME, TSUTOMU  (contact);ZHANG, HAO F

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Adrenal Cortex Hormones;Affect;age related;Anatomy;Angiopoietins;Animals;Anterior eyeball segment structure;aqueous;Aqueous Humor;Area;Blindness;Blood Vessels;Cardiac;Cells;Characteristics;Circulation;Data;Detection;Development;Disease;dominant genetic mutation;Drainage procedure;early onset;Electron Microscopy;Endothelial Cells;Evaluation;experimental study;Extracellular Matrix;Eye diseases;Family;FOXC2 gene;Gene Expression;Glaucoma;Goals;Height;Histologic;Human;Image;Imaging Techniques;Imaging technology;Immunohistochemistry;Impairment;improved;in vivo;Lighting;Limb structure;Lymph;Lymphatic;Lymphedema;Maintenance;Measurement;Measures;Mediating;member;Mesenchymal;meter;Methodology;Methods;Mission;modifiable risk;Molecular;Molecular Analysis;Morphology;Mus;mutant;Mutant Strains Mice;Mutation;nano;nerve damage;Neural Crest;novel;novel diagnostics;Ocular Hypertension;ocular imaging;older patient;Optic Nerve;optic nerve disorder;Optical Coherence Tomography;Pathologic;Pathway interactions;Patients;Phase;Physiologic Intraocular Pressure;Play;pressure;primary congenital glaucoma;Public Health;Research;Resistance;Resolution;Retina;Risk Factors;Role;Scanning;Signal Pathway;single-cell RNA sequencing;Speed;Structure;Structure of sinus venosus of sclera;System;Testing;Therapeutic;therapeutically effective;Three-Dimensional Imaging;Time;Tissues;Trabecular meshwork structure;transcription factor;Variant;Vascular Endothelial Cell;Vascular Endothelial Growth Factor Receptor-3;Vascular System;Veins;Visible Radiation;Vision;Visual impairment;Width;Wild Type Mouse

PROJECT_TITLE: Novel ocular imaging and molecular analysis of anterior eye segment for glaucoma


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: RELEVANCE TO PUBLIC HEALTH L-asparaginase is a standard-of-care treatment for lymphoblastic leukemia. This study will examine the rational combination of L-asparaginase with metformin, another FDA-approved drug, to effectively block kidney cancer growth, expand use of these compounds to renal cell carcinoma, and potentially enhance the efficacy of standard-of-care immune checkpoint blockade.

PI_NAMEs: CHRISTOFK, HEATHER  (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: activating transcription factor 1;activating transcription factor 4;Acute Lymphocytic Leukemia;Affect;Amino Acids;Anabolism;Animals;anticancer activity;asparaginase;Asparagine;Aspartate;Aspartate-Ammonia Ligase;Binding;Biodistribution;cancer cell;Cancer Cell Growth Regulation;cancer cell subtype;cancer therapy;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;cell growth;Cell Proliferation;Cells;Clinical;clinical translation;Complex;Consumption;CRISPR/Cas technology;Data;Dependence;detection of nutrient;dietary;Electron Transport;Environment;extracellular;FDA approved;Fibroblasts;FRAP1 gene;Genetic;Genetic Transcription;Genetically Engineered Mouse;Genomics;Growth;Homing;Immune;immune activation;immune checkpoint blockade;Impairment;Implant;in vitro activity;in vivo;inhibitor;Kidney;Knock-out;Leucine;leukemia;Lymphoblastic Leukemia;Lysosomes;Macrophage;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Mediating;Metabolic;Metabolism;metabolomics;Metformin;Methods;Mitochondria;Modeling;Molecular;mortality;mouse model;Mus;NADH dehydrogenase (ubiquinone);Nutrient;Pathway interactions;Patients;Pharmaceutical Preparations;Phosphotransferases;Population;Production;Proliferating;Proteins;Public Health;recruit;Regulation;Renal Carcinoma;Renal Cell Carcinoma;Reporting;Resistance;Respiration;Route;sensor;Serum;Signal Transduction;single-cell RNA sequencing;standard of care;subcutaneous;T-Lymphocyte;Testing;Therapeutic;therapeutic target;Tissues;tumor;tumor growth;tumor microenvironment;tumorigenesis;Western Blotting;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Nutrient Regulation of Cancer Cell Growth


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Clinical Research;Genetics;Infectious Diseases;Neurosciences;Vector-Borne Diseases

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative Mosquitoes infect hundreds of millions of people with deadly pathogens every year. Since mosquitoes rely heavily on their sense of smell to find and bite humans, one promising strategy to control such pathogens is the deployment of repellant and attractive odor blends that push mosquitoes away from humans or pull them into lethal traps. Our research will provide a transformative inroad into the rational design of such blends by uncovering the molecular and functional properties of the sensory neurons mosquitoes use to detect odors and by providing the genetic tools necessary to manipulate them.

PI_NAMEs: MCBRIDE, CAROLYN SARAH (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Acceleration;Aedes;Afferent Neurons;Arboviruses;Area;Axon;Behavior;Brain;Cell Nucleus;cell type;Chemicals;CRISPR/Cas technology;Culicidae;Data;design;Detection;Disease Vectors;Drosophila genus;Equation;experimental study;Female;flexibility;Flowers;Gene Library;Genetic;genome editing;High-Throughput Nucleotide Sequencing;Human;Human Bites;Image;in vivo;Individual;Label;Ligands;Lobe;Logic;Maps;Maxilla;Molecular;Mosquito Control;Mosquito-borne infectious disease;neural;Neurons;Odors;Olfactory Pathways;olfactory receptor;olfactory sensory neurons;Oviposition;pathogen;Pattern;Peripheral;Persons;Population;Property;rational design;Reagent;receptor;Research;Resolution;Resources;response;single nucleus RNA-sequencing;Site;Smell Perception;Sorting;Technology;Terminator Codon;tool;transcription factor;transcriptome;vector control;vector mosquito;vinegar fly;Volatilization;Work

PROJECT_TITLE: Molecular and functional characterization of olfactory pathways in the arbovirus vector mosquito Aedes aegypti

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Substance Misuse

ORG_CITY: HADLEY

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: PROJECT NARRATIVE Chronic alcohol use and chronic stress result in disruptions in multiple aspects of cognition, particularly under demanding conditions necessitating high levels of cognitive effort. This project will identify alcohol- and stress- induced changes in a key neural circuit underlying both the ability to deploy cognitive effort, including the locus coeruleus, anterior cingulate, and dorsal striatum. Results from these studies will provide a new cognitive effort-based perspective on the relationship between cognitive function and alcohol use disorder and will identify new treatment strategies related to enhancing cognitive effort to prevent problematic alcohol use.

PI_NAMEs: MOORMAN, DAVID E;VAZEY, ELENA  (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Adrenergic Receptor;Air;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol exposure;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;Anterior;Attention;Behavior;behavior prediction;Behavioral;Brain Stem;Buffers;Chronic;chronic alcohol ingestion;Chronic stress;cingulate cortex;Clustered Regularly Interspaced Short Palindromic Repeats;Cognition;Cognitive;cognitive ability;cognitive enhancement;cognitive function;cognitive performance;cognitive reappraisal;Collaborations;Corpus striatum structure;craving;Decision Making;density;Dimensions;discounting;Dorsal;drinking;Electrodes;Ethanol;executive function;Exhibits;Expenditure;Exposure to;flexibility;frontal lobe;Future;Goals;Heterogeneity;Impaired cognition;improved;Individual;Individual Differences;Influentials;insight;interest;Investigation;knock-down;Label;locus ceruleus structure;Measures;Mediating;member;Memory;Mus;neural;neural circuit;Neuroimmune;neuronal excitability;Neurons;Neurophysiology - biologic function;noradrenergic;Norepinephrine;norepinephrine system;novel;novel therapeutic intervention;optogenetics;Performance;Phosphodiesterase Inhibitors;prevent;receptor;receptor expression;Recording of previous events;Regimen;Regulation;Research;Research Personnel;restraint;Rewards;Role;Sex Differences;Short-Term Memory;Signal Transduction;Stress;stressor;sustained attention;Swimming;System;Task Performances;Testing;Time;Viral;willingness;Work

PROJECT_TITLE: 3/8: INIA Stress and Chronic Alcohol Interactions: Norepinephrine and corticostriatal circuit regulation of cognitive effort after chronic alcohol and stress


NIH_SPENDING_CATS: Congenital Structural Anomalies;Kidney Disease;Pediatric;Polycystic Kidney Disease

ORG_CITY: PISCATAWAY

ORG_DEPT: GENETICS

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

PHR: Project Narrative Cilia are found on most non-dividing cells in the body, perform many functions, and when faulty, cause human diseases called ciliopathies. In nephronophthisis-related ciliopathies (NPHP-RCs), mutations in a single gene can cause different disease spectrums (renal, neurological, skeletal, retinal, cardiac, and other abnormalities), indicating the importance of understanding ciliary specialization. The application uses the C. elegans model system to identify conserved mechanisms regulating ciliary specialization, remodeling, and plasticity, which important therapeutic implications as cilia are found on nearly every non-dividing cell in the human body.

PI_NAMEs: BARR, MAUREEN M (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Adult;Animals;Automobile Driving;Autosomal Dominant Polycystic Kidney;Basic Science;Biogenesis;Biological Models;Biology;Caenorhabditis elegans;Cardiac;cell type;Cells;Centrosome;Cilia;ciliopathy;Clinical;Code;combinatorial;Cystic Kidney Diseases;Defect;Development;developmental plasticity;Disease;electron tomography;Event;extracellular vesicles;Flagella;Future;Gatekeeping;Gene Expression Profiling;Gene Mutation;gene therapy;Genes;Goals;Health;Homologous Gene;Human;Human body;Human Development;human disease;Image;in vivo;innovation;Interphase Cell;katanin;Kidney;Leber's amaurosis;Length;loss of function;Male Infertility;Measures;Microtubule-Associated Proteins;Microtubules;Modeling;Molecular;mutant;Mutation;Nature;Nephronophthisis;nephronophthisis-related ciliopathy;Neurologic;Neurons;Play;Property;Proteins;Proteomics;proteostasis;regeneration potential;Regulation;Resolution;Retina;Retinal Degeneration;Role;Severities;Situs Inversus;skeletal;Sorting;Spatial Distribution;Structure;success;Symptoms;Syndrome;System;Tertiary Protein Structure;Testing;Therapeutic;Tissues;Tubulin;Variant;vesicular release;Visualization

PROJECT_TITLE: Nephronophthisis-related ciliopathies and ciliary specialization

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: BATON ROUGE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: Project Narrative Hazardous drinking among Black individuals in the United States poses a major public health concern. The proposed research aims to better understand antecedents of alcohol use motivation and hazardous drinking among this population by examining racial/ethnic microaggressions (MAs) – brief, subtle forms of everyday discrimination due to racial/ethnic status – that may prompt Black persons to be more motivated to drink to mitigate MA-related negative affect and engage in risky patterns of alcohol use. Through this research, we also will explore mediational processes and moderators in the MA-hazardous drinking relations that will inform future intervention and prevention efforts for this neglected health disparities group.

PI_NAMEs: BUCKNER, JULIA D (contact)

PROGRAM_OFFICER_NAME: RUFFIN, BEVERLY

PROJECT_TERMS: Accounting;Address;Adult;Affect;alcohol consequences;Alcohol consumption;alcohol craving;alcohol effect;alcohol misuse;alcohol research;alcohol use disorder;Anger;Anxiety;Behavioral;binge drinking;Biological;Black American;Black Populations;Black race;Caring;Chronic;Communities;coping;Coping Skills;Data;Depressed mood;Discrimination;Distress;diversity and inclusion;drinking;Ecological momentary assessment;emotional symptom;ethnic identity;Ethnic Origin;Ethnic Population;expectation;experience;Exposure to;Female;Frequencies;Future;Goals;hazardous drinking;health disparity;health disparity populations;health equity;health equity promotion;health inequalities;Heavy Drinking;high risk drinking;improved;Individual;insight;Intention;Intervention;intervention program;Investigation;Knowledge;Life;marginalized population;meetings;men;Mental Depression;Mental Health;Methodology;microaggression;minority health;minority stress;Modeling;Motivation;National Institute on Alcohol Abuse and Alcoholism;Nature;negative affect;neglect;non-verbal;Not Hispanic or Latino;Outcome;Participant;Pattern;perceived discrimination;Persons;Population;Prevention;Prevention program;Process;promote resilience;prospective;Public Health;Race;racial discrimination;racial identity;racial minority population;racial population;racism;Religiosity;Reporting;Research;Research Project Grants;resilience;resilience factor;response;Risk Assessment;Risk Factors;Role;Sampling;social;Strategic Planning;Stress;stressor;substance use;Symptoms;Testing;time use;United States;United States National Institutes of Health;verbal;Woman;Work

PROJECT_TITLE: Black Hazardous Drinkers: Ecological Momentary Assessment of Racial/Ethnic Microaggressions

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


ORG_NAME: BIRMINGHAM VA MEDICAL CENTER

PHR: Bladder cancer (BLCa) is the 4th most common cancer and the 7th most deadly in male veterans. Almost all cancer deaths are caused by advanced bladder cancer (aBC) which is the focus of this collaborative study. Patients with aBC usually receive medical treatment which includes chemotherapy, immunotherapy and targeted therapy, and, in case of locally advanced bladder cancer, radical cystectomy. Medical treatment is at most moderately effective. The goal of this collaborative application is to improve the treatment outcomes of aBC through revamping all four therapies from three complementary research teams with expertise in basic science, translational research, medical oncology and urology. We hypothesize that the prognosis and patient quality of life in aBC can be improved through optimizing all therapeutic modalities from research teams with complementary expertise.

PI_NAMEs: FERGUSON, JAMES E (contact)

PROJECT_TERMS: ARID Domain;Autophagocytosis;Award;Basic Science;Binding;Biological;Biological Assay;Biology;Cancer Biology;cancer immunotherapy;Cancer Patient;Candidate Disease Gene;Caring;Cause of Death;Cell Death;Cells;Chemoresistance;chemotherapy;Chromatin Remodeling Factor;Cleavage Under Targets and Release Using Nuclease;Co-Immunoprecipitations;Collaborations;Complex;Correlative Study;Cytotoxic Chemotherapy;Data;Dependence;design;Diagnostic;Down-Regulation;efficacy testing;Epigenetic Process;experimental study;Exposure to;EZH2 gene;Funding;Genes;Genetic Transcription;Goals;Grant;Human;Immune;Immunocompetent;Immunotherapy;improved;improved outcome;In Vitro;in vivo;inhibitor;Investigation;Maintenance Therapy;male;malignant mouth neoplasm;Malignant neoplasm of urinary bladder;Malignant Neoplasms;MAP Kinase Gene;Mediating;Medical;Medical Oncology;Modality;Modeling;Molecular;multicatalytic endopeptidase complex;mutant;Mutate;Mutation;novel;Operative Surgical Procedures;Oral;Pathway interactions;Patients;personalized medicine;pharmacologic;Phase II Clinical Trials;Phenotype;PI3K/AKT;PIK3CG gene;PIK3R3 gene;Process;Prognosis;Proteins;Quality of life;Radical Cystectomy;Research;Research Personnel;Research Project Grants;Role;Sampling;Signal Transduction;synergism;targeted treatment;Testing;theranostics;Therapeutic;Toxic effect;Translational Research;Treatment outcome;tumor;tumor growth;Ubiquitination;Up-Regulation;Urology;Veterans;Western Blotting

PROJECT_TITLE: BCCMA: Translational research to improve the care of advanced bladder cancer


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Pediatric - AIDS;Prevention

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: Project Narrative There is a paucity of support for young people living with HIV (YLWH) who often fail to achieve viral suppression, with catastrophic consequences in particular in resource-constrained countries in which treatment options are limited. This study aims to improve ART adherence among YLWH by providing small incentives based on insights from behavioral economics, combined with text messages sent by mobile phone. The approach is particularly targeted at those with low adherence as it allows to adjust eligibility thresholds for incentives to participants’ initial adherence, thereby reducing health inequality and facilitating high, long-term ART adherence for a particularly vulnerable group of HIV clients.

PI_NAMEs: HUANG, HAIJING ;LINNEMAYR, SEBASTIAN  (contact)

PROGRAM_OFFICER_NAME: YATES, FRANKLIN WILLEM

PROJECT_TERMS: acceptability and feasibility;Adherence;aged;American;arm;Behavior;behavior change;Behavioral;behavioral economics;Cellular Phone;Client;Clinical;cognitive control;comparative;comparison control;Control Groups;cost;cost effectiveness;Cost Effectiveness Analysis;Country;COVID-19;design;Development;discounting;Dropout;Effectiveness;effectiveness evaluation;effectiveness testing;Eligibility Determination;empowerment;Future;Goals;Health behavior;health inequalities;HIV;HIV Seropositivity;improved;Incentives;Individual;insight;Intervention;Journals;Maintenance;Measures;medication compliance;novel;Odds Ratio;Ownership;Participant;Persons;Phase;Pilot Projects;Preventive;primary outcome;Process;Public Health;Publishing;Qualifying;Randomized, Controlled Trials;relative effectiveness;Reporting;Research;Resources;Rewards;Risk Taking;secondary outcome;Self-control as a personality trait;South Africa;standard of care;systematic review;Testing;Text Messaging;theories;Time;tool;treatment arm;Treatment outcome;Uganda;Viral;Viral Load result;Vulnerable Populations;willingness;Work;Youth

PROJECT_TITLE: Goals for Adherence with Low-cost Incentives (GOALS)

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Genetics;Human Genome;Mental Health;Mental Illness;Substance Misuse

ORG_DEPT: PSYCHIATRY

PHR: Project Narrative / Relevance Now in its 13th year, the Psychiatric Genomics Consortium is perhaps the most innovative and productive experiment in the history of psychiatry. We propose to expand the work of the PGC so we can learn key lessons about the fundamental basis of major psychiatric disorders

PI_NAMEs: AGRAWAL, ARPANA  (contact);EDENBERG, HOWARD J;GELERNTER, JOEL

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: Acceleration;Address;Affect;Alleles;base;biobank;Biological;Biology;Biotechnology;career;case control;Cells;Clinical;Collaborations;Communication;Communities;Country;Data;Diagnostic;digital media;Disease;DNA Resequencing;education resources;Educational Materials;Ensure;Epidemiology;exome;exome sequencing;experimental study;Facebook;Family;Fostering;functional genomics;Funding;Genes;Genetic;genetic architecture;genetic pedigree;Genetic Variation;Genets;Genome;genome sequencing;genome wide association study;genomic data;genomic locus;Genomics;Goals;improved;Individual;Industry;innovation;insight;Institution;instrument;Investments;Journals;Knowledge;Learning;Life;Maps;Measures;Medical;Medicine;Mendelian randomization;Mental disorders;Meta-Analysis;Methods;Mission;Modeling;Molecular;National Institute of Mental Health;Nature;Neurosciences;novel;novel therapeutics;Outcome;outreach;Paper;patient stratification;patient subsets;Patients;Phase;Phenotype;predict clinical outcome;Productivity;Psychiatric Diagnosis;psychiatric genomics;Psychiatry;rare variant;Recording of previous events;Reproducibility;Research Personnel;Resistance;Resources;Risk;Risk Factors;Science;Scientist;severe psychiatric disorder;Source;statistics;success;Symptoms;Therapeutic;therapeutic development;Time;translational potential;Twitter;Update;Variant;whole genome;Work;working group

PROJECT_TITLE: 7/7 Psychiatric Genomics Consortium: Advancing Discovery and Impact

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-B(02)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Mutations in the mitochondrial genome can cause severe and devastating disorders. The research described here aims to understand the propagation of mutant mitochondrial genomes. Insights gained from this work will allow for better prediction of disease development, and for the eventual discovery of therapeutics.

PI_NAMEs: PATEL, MAULIK R (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TITLE: Mechanisms of mutant mitochondrial genome modulation

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ORG_DEPT: SURGERY

PHR: NARRATIVE We propose the development of the Surgical Multidisciplinary Access to Research in Residency Training (SMART) program to develop the next generation of surgical oncology physician scientists. SMART is anchored by the Northwestern University Department of Surgery's successful history of two-year dedicated research training for residents, by a highly accomplished team of Northwestern researchers and clinicians to provide tailored-mentoring for the residents, and by the unique >15-year partnership in training surgical research residents in conjunction with the American College of Surgeons' Cancer Programs. SMART will be a national leader in increasing the pipeline of qualified surgical oncology physician scientists who go on to faculty positions, with independently funded research agendas, making seminal contributions to the field, and mentoring their own trainees, while also delivering high-quality, compassionate care to cancer patients.

PI_NAMEs: KHAN, SEEMA AHSAN (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Accreditation;Advisory Committees;American;American College of Surgeons;Area;Articulation;Basic Science;Cancer Patient;career;career development;career networking;Caring;Certification;Clinical;Clinical Research;Collaborations;Comparative Effectiveness Research;Competence;Comprehensive Cancer Center;Databases;Dedications;design;Development;Diagnosis;early-career faculty;Educational Curriculum;Educational process of instructing;Educational workshop;Eligibility Determination;Ensure;Ethics;Evaluation;experience;Faculty;Fellowship;Funding;Future;Goals;Health Services Research;improved;Joints;Journals;Knowledge;Leadership;Learning;Malignant Neoplasms;medical schools;medical specialties;Medicine;meetings;Mentors;Mentorship;Methodology;Modeling;Monitor;multidisciplinary;next generation;Oncology;Operative Surgical Procedures;Outcomes and Health Services Research;Outcomes Research;Palliative Care;Patient Care;Physicians;Positioning Attribute;Postdoctoral Fellow;Prevention;Productivity;Professional Organizations;Program Evaluation;programs;Publications;Qualifying;Recording of previous events;recruit;Research;research and development;Research Design;Research Personnel;Research Project Grants;Research Training;Residencies;Science;Scientist;screening;Seminal;skills;success;support network;Surgeon;Surgical Oncology;surgical research;survivorship;Time;Training;training opportunity;Training Programs;Translational Research;Underrepresented Populations;Universities

PROJECT_TITLE: Surgical Multispecialty Access to Research in Residency Training (SMART)


ORG_CITY: St. Louis

ORG_NAME: ST. LOUIS VA MEDICAL CENTER

PHR: PROJECT NARRATIVE Obesity is a significant risk factor for cardiovascular disease and diabetes. Multiple studies hypothesize that environmental factors in utero program patterns of infant growth that result in increased susceptibility to obesity and insulin resistance later in life. We found that vitamin D deficiency in utero increased obesity and insulin resistance despite postnatal vitamin D supplementation. These metabolic abnormalities can be transplanted by macrophages reprogrammed in utero by vitamin D deficiency. Moreover, we found this risk is reversible in humans by vitamin D supplementation during pregnancy. This application will explore the role of macrophages and their genetic program in developing adipose differentiation and insulin resistance induced by in utero vitamin deficiency and characterize how antenatal vitamin D supplementation in humans reduces obesity and insulin resistance in the offspring. Our results will provide a better understanding of the programming of immune cells in utero contributing to obesity and the need for vitamin D supplementation during pregnancy.

PI_NAMEs: BERNAL-MIZRACHI, CARLOS  (contact)

PROJECT_TERMS: 10 year old;active duty;Address;adipocyte differentiation;Adipocytes;Adipose tissue;Age;antenatal;Area;Award;Birth;Blood specimen;Body mass index;Bone Marrow;Breast Feeding;Cardiovascular Diseases;cardiovascular risk factor;Caring;Cells;Child;child bearing;cohort;Development;Diabetes Mellitus;differentiation in vitro;disorder risk;early pregnancy;early screening;Early treatment;Eating;Eligibility Determination;Embryo;Embryonic Induction;Energy Metabolism;Environmental Risk Factor;Epigenetic Process;Expenditure;Family;Family member;Fatty acid glycerol esters;fetal;Fibroblasts;First Pregnancy Trimester;Future;General Population;Genetic;Growth;Health;Health Personnel;Health system;Hematopoietic stem cells;Human;Hypertension;Hypertriglyceridemia;Immune;immunoregulation;improved;in utero;Incidence;Infant;Infiltration;Insulin Resistance;Life;Macrophage;maternal obesity;Measures;Metabolic;Metabolic Diseases;Methylation;Military Personnel;military service;monocyte;Mothers;Multivitamin;Mus;Myeloid Cells;obese person;Obesity;obesity development;obesity prevention;obesity risk;offspring;offspring obesity;Overweight;Pathway interactions;Pattern;Phenotype;Placebos;Population;postnatal;Predisposition;Pregnancy;pregnant;Pregnant Women;prenatal;Prevalence;prevent;Process;programs;Proliferating;Randomized, Controlled Trials;recruit;Risk;Role;screening;Serum;specific biomarkers;Stimulus;Sun Exposure;Supplementation;System;systemic inflammatory response;Testing;Tissue Differentiation;Tissue Expansion;Tissues;Transfection;Transplantation;Umbilical Cord Blood;Up-Regulation;Veterans;Vitamin D;Vitamin D Deficiency;Vitamin D supplementation;Vitamin Deficiency;Weight;Weight Gain;Woman;young adult

PROJECT_TITLE: Vitamin D and Development Origins of Obesity and Insulin Resistance


ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE The proposed work will investigate the role that repetitive regions in the human genome play in cardiovascular disease risk. New statistical and computational approaches will be developed to estimate the lengths of repeats in the genome in existing genotyped cohorts, lengths which are hard to ascertain directly from the available DNA microarray data. The fraction of heritability of cardiovascular disease which is explained by variance in repeat lengths will be quantified, shedding light on the genetic bases for these diseases.

PI_NAMEs: MUKAMEL, RONEN  (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Affect;All of Us Research Program;Alleles;Atrial Fibrillation;Attention Deficit Disorder;base;Base Pairing;Base Sequence;biobank;Biological Assay;Blood;Blood Pressure;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Cataloging;Cause of Death;Cessation of life;Cholesterol;cohort;Computer software;Coronary Arteriosclerosis;Data;Development;Diploidy;Disease;DNA Microarray Chip;DRD4 gene;Family Study;Fragile X Syndrome;Future;Genes;Genetic;genetic architecture;genetic association;Genome;genome sequencing;genome wide association study;genome-wide;Genomics;Genotype;genotyping technology;Goals;Health;Heritability;Human;Human Genome;Huntington Disease;Hypertension;Individual;interest;Ischemic Stroke;Length;Light;Link;Lipids;Lipoprotein (a);Maps;Measures;Methodology;Methods;Micro Array Data;Minisatellite Repeats;Modeling;Mutation;open source;Outcome;Phase;Phenotype;Play;Population;Procedures;programs;Proteins;rare variant;Repetitive Sequence;Research;Resolution;risk variant;Role;Sample Size;Single Nucleotide Polymorphism;Statistical Algorithm;Statistical Methods;Stretching;Testing;trait;United States National Institutes of Health;Variant;whole genome;Work

PROJECT_TITLE: Exploring the role of genomic repeats in cardiovascular disease heritability

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Congenital Structural Anomalies;Pediatric;Regenerative Medicine;Urologic Diseases

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE  The results of this proposal are anticipated to produce new tissue repair modalities that will overcome current limitations in urethroplasty by creating novel “off-the-shelf” silk fibroin grafts capable of urethral delivery of stem cell homing factors, stromal cell–derived factor-1 alpha (SDF1α/CXCL12) and monocyte chemoattractant protein-1 (MCP1/CCL2) for reconstruction of long urethral strictures. We also seek to uncover what role CXCR4- SDF1α/CXCL12 and CCR2-MCP1/CCL2 dependent, mesenchymal stem cell (MSC) homing plays in scaffold- mediated, constructive remodeling of urethral strictures following urethroplasty. We anticipate the results of this study will provide new information that is wider in scope than our specific goals and which may be applicable for repair of other urinary tract organs (ureter, bladder) in general.

PI_NAMEs: MAUNEY, JOSHUA ROBERT (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Adipose tissue;Adopted;Adult;Anastomosis - action;Animal Model;Anti-Inflammatory Agents;Autologous;Biocompatible Materials;biodegradable scaffold;Bladder;Bombyx;Bombyx mori;Bone Marrow;CCL2 gene;Cell Count;Cells;Characteristics;chemokine;Childhood;Chronic;Clinical;clinical practice;Complex;Congenital Abnormality;controlled release;CXCR4 gene;CXCR4 Receptors;Defect;Development;Devices;Disease;Elasticity;End stage renal failure;Epispadias;Excision;experimental study;Family suidae;Female;Fibroins;Fibrosis;Fistula;flexibility;Functional disorder;functional restoration;Genitalia;Goals;Growth;healthcare burden;high risk;Homing;Human;Hydrogels;Hypospadias;immunogenicity;Implant;improved;In Vitro;Incontinence;Infertility;Injury;innovation;Laboratories;Length;male;mechanical properties;Mediating;Mesenchymal Stem Cells;Modality;Modeling;monocyte chemoattractant protein 1 receptor;Morbidity - disease rate;Natural regeneration;novel;Obstruction;Operative Surgical Procedures;Oral mucous membrane structure;Organ;Oryctolagus cuniculus;Outcome;paracrine;Pathologic;patient population;Patients;Pharmaceutical Preparations;Play;Polyesters;porcine model;pre-clinical;preservation;Publishing;receptor-mediated signaling;reconstruction;recruit;Recurrence;repaired;replacement tissue;Reporting;Research;Resources;Role;scaffold;Seed Implantation;Serious Adverse Event;side effect;Signal Pathway;Signal Transduction;Silk;Site;Skin;Source;stem cell delivery;stem cells;Stromal Cell-Derived Factor 1;Surgical Management;Techniques;Tensile Strength;Testing;Tissue Engineering;Tissue Grafts;tissue regeneration;tissue repair;Tissues;transdifferentiation;Trauma;Ureter;Urethra;Urethral Diseases;Urethral Diverticulum;Urethral Meatus Stenosis;Urethral Stricture;Urinary tract;Urinary tract infection;Urination;Urothelial Cell;Validation;wound care;wound healing

PROJECT_TITLE: Drug Eluting Silk Fibroin Grafts for Repair of Long Urethral Strictures

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Immunotherapy;Inflammatory Bowel Disease

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative This project focuses on investigating the molecular mechanisms that control the function of tissue-resident memory T cells in the gut. We will study these important immune cells both in the healthy colon and in colon inflammation induced by PD-1 and CLTA-4 antibody therapy, both in humans and relevant mouse models.

PI_NAMEs: DOUGAN, MICHAEL LAWRENCE (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Address;Adrenal Cortex Hormones;Advanced Malignant Neoplasm;Adverse event;Affect;anti-PD1 antibodies;Antibodies;Antibody Therapy;Autoimmune Diseases;Back;Bar Codes;Biopsy;Biopsy Specimen;Blocking Antibodies;Cancer Patient;CD8-Positive T-Lymphocytes;Cell Communication;Cell Physiology;Cells;Cellular Immunity;checkpoint inhibition;chemokine;chemokine receptor;Clinical;Clinical Data;Clinical Trials;Clonal Expansion;Colitis;Colon;Colonic inflammation;Combined Modality Therapy;commensal microbes;CTLA4 blockade;CTLA4 gene;cytokine;cytotoxic;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data;Development;Diagnosis;Diagnostic;Dietary Proteins;DNA;Enteritis;Epithelial Cells;Fc Receptor;Formalin;FOXP3 gene;Funding;Gene Expression Profile;Goals;Gut Mucosa;high dimensionality;Homeostasis;Human;human model;imaging approach;Imaging Techniques;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immunity;Immunofluorescence Immunologic;Immunologics;Immunology;immunoregulation;Individual;Inflammatory;insight;intestinal homeostasis;Intestinal Mucosa;Invaded;Lead;Lung;Memory;Molecular;Monoclonal Antibodies;mouse model;Mucous Membrane;Mus;Myeloid Cells;Paraffin Embedding;participant enrollment;pathogen;Pathogenesis;Pathway interactions;Patients;Phase II Clinical Trials;Physiological;Population;programmed cell death protein 1;Proliferating;Pulmonary Inflammation;Randomized;receptor;receptor function;Receptor Inhibition;Regulation;Regulatory T-Lymphocyte;Reporting;response;Role;Signal Transduction;single cell analysis;single cell sequencing;single-cell RNA sequencing;Small Intestines;Specimen;Stromal Cells;Surface;Suspensions;T-Cell Receptor;T-Lymphocyte;Techniques;Technology;Therapeutic;Therapeutic Agents;therapeutic target;Time;Tissue Embedding;tissue resident memory T cell;Tissues;TNF gene;tool;tumor-immune system interactions

PROJECT_TITLE: Molecular Pathways Regulating Tissue-resident Memory T cells in the Gut

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ORG_DEPT: DERMATOLOGY

PHR: PROJECT NARRATIVE Cadherin clustering is a unique molecular process that mediates and controls cell-cell adhesion. In addition, it also regulates the actin cytoskeleton, polarity, proliferation, and apparently other structures and signaling pathways. Despite such incredibly important functions, which obviously play out in nearly every aspect of tissue morphogenesis, the molecular mechanisms and regulation of cadherin clustering remains to be studied. This proposal will shed light on how different types of cadherin clusters form and how they participate in such diverse array of cellular mechanisms. The study is a critical step toward the development of synthetic modulators cell-cell adhesion and their application in medicine.

PI_NAMEs: TROYANOVSKY, SERGEY M (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TITLE: Cadherin Clusters and actin filaments

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Disability Research;Down Syndrome;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_NAME: GRADUATE SCHOOL OF PUBLIC HEALTH AND HEALTH POLICY

PHR: Project Narrative In the United States, adolescents and young adults with intellectual and developmental disabilities (I/DD) are less likely to receive comprehensive sex education and to use reproductive health services than their non- disabled peers. We will test the efficacy of the STEPS-2 socialization and sex education program on increased access to reproductive health services for individuals aged 18-27 with mild to moderate I/DD in a randomized intervention trial. As one of the first such randomized trials among this population, the findings will inform best practices in sex education to improve the reproductive health of youth with I/DD as they transition from adolescence to adulthood, as well as best practices for incorporating individuals with I/DD in public health research.

PI_NAMEs: JONES, HEIDI ELIZABETH;MCDERMOTT, SUZANNE W (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: 21 year old;academic standard;Adolescent;Adolescent and Young Adult;Adult;Advocate;African American;Age;age difference;age group;age related;aged;arm;Asian;Behavior;Child;Childhood;Communicable Diseases;community advisory board;community center;Complex;Contraceptive Agents;Contraceptive methods;Contraceptive Usage;Control Groups;Data;design;Developmental Delay Disorders;Developmental Disabilities;disability;Education;Educational Curriculum;Educational Intervention;effectiveness testing;efficacy testing;Eligibility Determination;Enrollment;Ensure;exercise intervention;experience;experimental group;Female;Fertility;Gender;Gender Identity;Health;Health education;health knowledge;Health Status;Healthcare;Hispanic;HIV;Home visitation;Human Papilloma Virus Vaccination;Hygiene;improved;Individual;Informed Consent;Intellectual functioning disability;Intention;intersectionality;Intervention;Intervention Trial;Interview;Knowledge;Latinx;Legal Guardians;Lived experience;Living Arrangement;male;Measures;Medicaid services;Medical;Menstruation;Monitor;New York;non-compliance;nutrition;open label;Participant;participant interview;peer;Persons;Phase;Physical Exercise;Population;Population Heterogeneity;Pregnancy;prevention practice;Preventive;primary endpoint;primary outcome;Process;Program Evaluation;programs;Provider;public health research;Randomized;randomized trial;Randomized, Controlled Trials;recruit;Reporting;Reproductive Health;Reproductive Health Services;Risk;Schools;screening;secondary outcome;Services;sex;Sex Behavior;Sex Education;Sexual Health;sexual victimization;Sexuality;sexually active;Sexually Transmitted Diseases;social;Socialization;South Carolina;success;Testing;transition to adulthood;translational study;Treatment Efficacy;United States;Unwanted pregnancy;Update;Voice;young adult;Youth

PROJECT_TITLE: A Randomized Intervention Trial to Increase Access to Reproductive Health Services among Adolescents and Young Adults with intellectual and Developmental Disabilities


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: SAN ANTONIO

ORG_NAME: TEXAS BIOMEDICAL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE The Interdisciplinary NexGen TB Research Advancement Center (IN-TRAC) at Texas Biomedical Research Institute will develop the next generation of TB researchers into independent scientists that work on some of the most challenging and relevant translational problems in the TB field. IN-TRAC will provide investigators with clinical and research knowledge combined with the soft skills necessary to move with confidence across multiple academic disciplines and within a framework of highly collaborative research.

PI_NAMEs: SCHLESINGER, LARRY S. (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Address;Animal Model;Animals;biocontainment facility;Biomedical Research;career development;cellular imaging;Chest;Cities;Clinic;Clinical;Clinical Management;Clinical Research;Clinical Services;cohort;commercialization;Communicable Diseases;Communication;Communities;Complement;Comprehension;Confocal Microscopy;Country;Cytometry;Development;Discipline;Educational Curriculum;experience;externship;Funding;Funding Agency;Grant;Health;Health Professional;Hospitals;IACUC;Image;Individual;Industry;Infectious disease threat;Inpatients;Interdisciplinary Study;Internships;Knowledge;Leadership;Learning;live cell imaging;Mechanics;metropolitan;Mexico;Mission;multidisciplinary;Mus;National Institute of Allergy and Infectious Disease;next generation;nonhuman primate;organizational structure;Outpatients;Participant;Patient Care;peer;PET/CT scan;point of care;prevent;Prevention;Procedures;programs;prospective;Protocols documentation;Research;Research Institute;Research Personnel;Resources;Risk Assessment;Rodent;Science;Scientist;single-cell RNA sequencing;Site;skills;success;Texas;tool;Training;Training Programs;Tuberculosis;United States National Institutes of Health;Universities;whole body imaging;Work;Writing

PROJECT_TITLE: Interdisciplinary NexGen TB research Advancement Center (IN-TRAC)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

PROJECT_TERMS: Address;Animals;biocontainment facility;Biomedical Research;Budgets;Chest;Cities;Clinic;Clinical;Clinical Management;Clinical Services;cohort;Communicable Diseases;Communication;Communities;Complement;Consultations;Country;design;Discipline;Ensure;experience;Funding Agency;Goals;Health;Health Professional;human subject;Individual;Infectious disease threat;Inpatients;Institution;Interdisciplinary Communication;Interdisciplinary Study;Knowledge;Leadership;Measures;meetings;metropolitan;Mexico;Mission;Monitor;multidisciplinary;National Institute of Allergy and Infectious Disease;next generation;organizational structure;Outpatients;peer;prevent;Primates;programs;prospective;Research;Research Institute;Research Personnel;Resources;responsible research conduct;Safety;Schedule;Science;skills;Strategic Planning;Structure;success;Texas;tool;Tuberculosis;United States National Institutes of Health;Universities;Update;Work

PROJECT_TITLE: Administrative Core