NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Emerging Infectious Diseases;Genetics;HIV/AIDS;Hematology;Infectious Diseases;Neuroblastoma;Neurosciences;Orphan Drug;Pancreatic Cancer;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: SHARAN, SHYAM  (contact)

PROJECT_TERMS: Abdomen;Acinar Cell;Acinar Cell Carcinoma;Alleles;anaplastic thyroid cancer;Animals;APC gene;biobank;Biological;Biopsy;Cancer Model;cancer therapy;carcinogenesis;CCR;chemotherapy;Childhood Rhabdomyosarcoma;Clinical;cohort;Colonoscopy;combinatorial;comparative;CRISPR/Cas technology;Cyclin-Dependent Kinase Inhibitor 2A;Development;diagnostic strategy;Disease;disease model;Doxorubicin Hydrochloride Liposome;Drug Evaluation;Drug Targeting;drug testing;Engineering;Epigenetic Process;Evaluation;evaluation/testing;experimental study;Fibrous capsule of kidney;gastroenteropancreatic neuroendocrine tumor;Gastrointestinal tract structure;Genes;Genetic;Genetic Engineering;genome editing;Growth Factor;Hematopoietic Neoplasms;Histone Deacetylase Inhibitor;Histopathology;HIV Infections;HIV/AIDS;Imaging Device;Implant;implantation;improved;Incidence;Interleukin-6;Joints;Kaposi Sarcoma;Lesion;leukemia/lymphoma;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;Mission;Modeling;Molecular;Monitor;mouse model;Mus;Neuroblastoma;neuroendocrine cancer;Neuroendocrine Tumors;novel;Palpation;Pancreas;Papillary thyroid carcinoma;patient derived xenograft model;Patients;pre-clinical;pre-clinical assessment;Pre-Clinical Model;Preclinical Drug Evaluation;preclinical efficacy;Preparation;Procedures;programs;Proliferating;Protocols documentation;recombinase;Recurrence;Research Personnel;Research Support;Resources;response;sample collection;Sampling;Site;skin biopsy;small molecule inhibitor;somatostatin receptor 2;Stomach;success;Technology;Therapeutic;therapeutic development;therapeutic target;Tissues;transcriptomics;Transgenes;tumor;Tumor Suppressor Genes;Validation;Xenograft procedure

PROJECT_TITLE: Preclinical Modelling and Therapeutic Development for Other Cancer Indications


ACTIVITY: ZIA

ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: DIVISION OF BASIC SCIENCES - NCI

PI_NAMEs: ALDAPE, KENNETH  (contact)

PROJECT_TERMS: cancer biomarkers;cancer type;Categories;Central Nervous System Neoplasms;Classification;clinically relevant;Data;Data Set;deep learning;deep learning model;demographics;Diagnosis;digital pathology;DNA Methylation;DNA Sequence Alteration;Future;Gene Expression;genome wide methylation;genomic biomarker;Goals;Histopathology;Image;Medicine;Methylation;Modeling;Molecular;Nature;Paper;Pathologist;Patients;Publishing;Sampling;Slide;Testing;Time;Training;tumor

PROJECT_TITLE: Genomic Biomarkers of Cancer


NIH_SPENDING_CATS: Cancer;Clinical Research;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: WIDEMANN, BRIGITTE  (contact)

PROJECT_TERMS: Adolescent and Young Adult;Adrenocortical Carcinoma;Adult;Advocacy;Advocate;Affect;Age;Back;biobank;Biological;Biological Models;Biological Specimen Banks;Biology;Biopsy;Blood;cancer imaging;CCR;Childhood;Chordoma;Clinic;Clinical;clinical center;Clinical Trials;cohort;Collection;Communication;Communities;community engagement;Country;COVID-19 pandemic;Data;Data Collection;Databases;Dedications;Deposition;Development;Disease;Educational workshop;Eligibility Determination;Enrollment;Evaluation;Experimental Models;Family;Funding;Gastrointestinal Stromal Tumors;genetic counselor;Goals;Health Personnel;Health Sciences;Histology;improved;Infrastructure;interest;International;Intervention;Learning;Malignant Childhood Neoplasm;Malignant Neoplasms;Medical History;Medical Oncology;Medical Records;medullary thyroid carcinoma;Molecular;Molecular Profiling;Mutate;Natural History;Neuroendocrine Tumors;novel therapeutics;Oncology;Online Systems;Operative Surgical Procedures;Oregon;Pancreatic carcinoma;Participant;participant enrollment;Patient advocacy;patient engagement;Patient Outcomes Assessments;Patients;PDGFRA gene;Pediatric Hospitals;Pediatric Neoplasm;Pediatric Oncology Group;Population;Process;programs;Protocols documentation;Quality of life;rare cancer;Recommendation;Recording of previous events;Research;Research Personnel;Review Literature;Sampling;Solid Neoplasm;Standardization;symposium;Testing;Texas;Translating;tumor;Tumor Pathology;United States National Institutes of Health;Universities;US State;Vertebral column;young adult

PROJECT_TITLE: MyPART: My Pediatric and Adult Rare Tumor Network - Cures


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

PI_NAMEs: GILBERT, MARK  (contact)

PROJECT_TERMS: acceptability and feasibility;Adult;Advocacy;Advocate;Agreement;Anxiety;Apple;Award;Awareness;Biological Markers;Biological Specimen Banks;Blood;Books;Brain Neoplasms;cancer care;Caregivers;Caring;CCR;Central Nervous System Diseases;Central Nervous System Neoplasms;Clinic;Clinical Research;Clinical Trials;Clinical Trials Network;cohort;Collaborations;Collection;Communities;Comprehensive Cancer Center;COVID-19;Data;data sharing;Dedications;Diagnosis;Education;Educational Activities;Educational workshop;Ependymoma;Event;Exhibits;Extramural Activities;Facebook;first-in-human;Fostering;Genetic Counseling;genetic testing;Glioblastoma;Glioma;gliosarcoma;Goals;Group Meetings;Guidelines;Health;Health Services Accessibility;human study;Immune checkpoint inhibitor;Immune response;Immunologic Monitoring;Immunologic Tests;Immunotherapy;improved;improved outcome;Individual;individual patient;Information Technology;Infrastructure;inhibitor;Institution;International;Intervention;Journals;Laboratories;Language;Lead;Leadership;lectures;Malignant neoplasm of central nervous system;Malignant Neoplasms;Medical;Medulloblastoma;meetings;member;meningioma;Methods;Molecular;molecular subtypes;Monitor;Multi-Institutional Clinical Trial;multidisciplinary;mutant;MYCN gene;National Comprehensive Cancer Network;Natural History;neuro-oncology;Neurology;Newsletter;Nivolumab;novel;novel therapeutics;Observational Study;oligodendroglioma;Oncology;Operative Surgical Procedures;Oral;Outcome;Paper;Participant;participant enrollment;Pathology;Patient advocacy;patient advocacy group;patient oriented;Patient-Focused Outcomes;Patients;Pediatric Oncology;Persons;Pharmaceutical Preparations;Physicians;Play;Pregnancy;Primary Brain Neoplasms;Privatization;Professional counselor;programs;Provider;psychological distress;psychological symptom;Publishing;Quality of life;Radiation;Radiation Oncology;Recurrence;Reporting;Research;research clinical testing;Research Personnel;Research Project Grants;Retrospective Studies;Risk;Science;sharing platform;Site;SKIL gene;Sleep;Societies;Spanish;Support Groups;Surveys;survivorship;symposium;Symptom Burden;Symptoms;Telemedicine;Testing;Time;Tissues;tool;Topoisomerase Inhibitors;translational immunology;Translations;treatment response;treatment trial;tumor;United States;United States National Institutes of Health;Update;virtual;virtual reality environment;Visit;visiting scholar;web site;webinar

PROJECT_TITLE: CONNECT: Comprehensive Oncology Network Evaluating Rare CNS Tumors - Cures


NIH_SPENDING_CATS: Cancer;Natural Products

PI_NAMEs: OKEEFE, BARRY  (contact)

PROJECT_TERMS: Acceleration;Actinobacteria class;Africa;Agreement;Analytical Chemistry;anti-cancer;anti-cancer research;antimicrobial;Antineoplastic Agents;Australia;Back;Basic Science;beta catenin;Bioinformatics;Biological Process;Biometry;Brazil;California;cancer cell;CCR;Chemicals;Collaborations;college;Communities;Computer software;Country;cytotoxic;Data;Data Collection;Databases;Disease;drug development;drug discovery;empowerment;Extramural Activities;Fermentation;Fractionation;Funding;fungus;genetic signature;genome sequencing;Genomics;Goals;Health;Helping to End Addiction Long-term;high throughput screening;Human;improved;Intramural Research;Investments;Korea;Laboratories;Legal patent;Libraries;Malignant Neoplasms;marine;material transfer agreement;Mediation;Medical center;Methods;Microbe;microorganism;Modernization;Molecular Target;Mus;National Cancer Institute;National Center for Advancing Translational Sciences;National Center for Complementary and Integrative Health;National Institute of Allergy and Infectious Disease;National Institute of Dental and Craniofacial Research;Natural product discovery;Natural Products;Natural Products Chemistry;new technology;novel;Organism;outreach;Plants;Procedures;Production;Productivity;programs;public database;Publishing;Research;Research Activity;Research Personnel;Resources;robotic system;Sampling;screening;screening program;Shipping;Soil;Source;Specimen;Spectroscopy, Fourier Transform Infrared;Structure;Sweden;Taxonomy;Technology;Terpenes;translational pipeline;tumor;United States;United States National Institutes of Health;Universities;whole genome;Work

PROJECT_TITLE: NCI Program for Natural Products Discovery - Cures


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Hematology;Immunotherapy;Lung;Lung Cancer;Prostate Cancer;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation;Urologic Diseases;Women's Health Research

PI_NAMEs: GRETEN, TIM  (contact)

PROJECT_TERMS: Acceleration;Agreement;Antigen Presentation;Australia;Authorization documentation;Automobile Driving;Blood Transfusion;Bone Marrow;Breast Carcinoma;Canada;cancer therapy;cancer type;Carcinoma;CCR;CD28 gene;CD34 gene;CD47 gene;Cell Therapy;Cells;cellular engineering;chimeric antigen receptor T cells;China;clinic ready;Clinical;clinical center;clinical development;Clinical Protocols;clinical trial protocol;Clinical Trials;Colon Carcinoma;Contracts;CRISPR screen;Data Analyses;Engineering;Epidermal Growth Factor Receptor;Europe;falls;first-in-human;Funding;Genes;Genetic Engineering;Goals;Human;Immune signaling;Immunosuppression;Interleukin-12;Japan;Legal patent;Lentivirus Vector;Lung Carcinoma;Malignant Neoplasms;manufacture;Maps;Mediating;Membrane;Modern Medicine;monocyte;Myelogenous;Myeloid Cells;Myeloid Progenitor Cells;neoplastic cell;Organ Transplantation;Patients;Pharmaceutical Preparations;Phase I Clinical Trials;Play;Process;Production;programs;Property;Prostate carcinoma;Protocols documentation;Review Committee;Role;Skin graft;Therapeutic;tumor progression;United States National Institutes of Health;Validation;vector;Writing

PROJECT_TITLE: Center for Cell-based Therapy - Cures


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Immunotherapy;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

PI_NAMEs: SALOURA, VASSILIKI  (contact)

PROJECT_TERMS: 11q13;Acute;Apoptosis;Biological Markers;BIRC2 gene;Blood;Blood specimen;Bortezomib;cancer infiltrating T cells;CASP3 gene;CD8-Positive T-Lymphocytes;Cessation of life;chemoradiation;chemotherapy;Chemotherapy and/or radiation;Chemotherapy-Oncologic Procedure;Cisplatin;Clinical;Combination Drug Therapy;Contracture;Cranial nerve diseases;curative treatments;Cytotoxic Chemotherapy;Data;Disease;DNA Damage;DNA Sequence Alteration;Dose;Dose Limiting;Drug Kinetics;Drug Targeting;exome sequencing;Facial nerve structure;Goals;Half-Life;head and neck cancer patient;Head and Neck Squamous Cell Carcinoma;Human;Human Papilloma Virus-Related Malignant Neoplasm;Immune;improved;Investigation;irradiation;Limb structure;Maximum Tolerated Dose;Mediating;Mobility decline;Modality;Modification;Mucous Membrane;Mus;Mutation;novel therapeutic intervention;objective response rate;Ohio;Operative Surgical Procedures;palliative chemotherapy;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacodynamic biomarker;phase 1 study;phase I trial;Phase I/II Trial;Postoperative Period;preclinical study;Prognosis;programmed cell death ligand 1;Progression-Free Survivals;Qualifying;Radiation;Radiation Oncology;Radiation therapy;Radiation-Sensitizing Agents;Radiodermatitis;Radiosensitization;Reactive Oxygen Species;Recurrence;Recurrent tumor;Regimen;response;Safety;safety assessment;Schedule;Spinal Cord;standard care;standard of care;Survival Analysis;Survival Rate;The Cancer Genome Atlas;Therapeutic;Toxic effect;transcriptome sequencing;trend;tumor;Tumor Tissue;United States National Institutes of Health;Universities;Unresectable;Visit;Weight

PROJECT_TITLE: IMRRT for Locoregionally Recurrent Head and Neck Squamous Cell Carcinoma


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Neurosciences;Rare Diseases

PI_NAMEs: HERNANDEZ, JONATHAN  (contact)

PROJECT_TERMS: Adenocarcinoma;Cessation of life;Development;Evaluation;Gastrointestinal tract structure;Humor;Innovative Therapy;Laboratories;Laboratory Research;Liver;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Metastatic Adenocarcinoma;Mission;Modeling;Neoplasm Metastasis;neoplasm therapy;neuroendocrine cancer;Neuroendocrine Tumors;novel;Operative Surgical Procedures;Patient Care;Patient-Focused Outcomes;phosphoproteomics;transcriptomics;Translational Research;United States;Work

PROJECT_TITLE: Evaluating outcomes for patients with primary-metastatic gastrointestinal cancer


NIH_SPENDING_CATS: Biotechnology;Cancer;Cardiovascular;Clinical Research;Congenital Structural Anomalies;Genetics;Heart Disease;Neurofibromatosis;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

PI_NAMEs: YOHE, MARIELLE  (contact)

PROJECT_TERMS: Address;Adult;Animal Model;Biochemical;Biological Assay;cancer prevention;cardiofaciocutaneous syndrome;Cardiomegaly;Cell Proliferation;Child;Childhood;Clinical;Clinical Investigator;Clinical Research;Clinical Trials;congenital heart abnormality;Costello syndrome;design;Development;Diagnosis;Disease;early phase clinical trial;effective therapy;efficacy evaluation;Embryo;epidemiology study;experimental study;Failure to Thrive;Fibroblasts;functional outcomes;gastrulation;General Population;Genes;Genetic Diseases;Genetic study;Genetically Engineered Mouse;Genomics;Germ Lines;Germ-Line Mutation;Goals;Grant;inhibitor;interdisciplinary approach;interest;Knockout Mice;Lead;Life;Long-Term Effects;Longitudinal cohort study;Malignant Childhood Neoplasm;Mammalian Cell;MAP Kinase Gene;MEKs;Modeling;Motor Activity;mouse model;Mus;Mutation;Myoblasts;Neurofibromatosis 1;Noonan Syndrome;novel;Pathway interactions;Patients;Pediatric Oncology;Peripheral Nerve Sheath Neoplasm;Phenotype;Plexiform Neurofibroma;Population;preclinical study;Prevention strategy;protein purification;Proteins;Risk;targeted agent;targeted treatment;Testing;Therapeutic;Tipifarnib;TP53 gene;Transfection;Transgenic Organisms;tumor;Variant;virulence gene;Work;Zebrafish;zebrafish development

PROJECT_TITLE: Advancing RAS and RASopathy Therapies


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Immunotherapy;Liver Cancer;Liver Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Precision Medicine;Prevention;Rare Diseases

PI_NAMEs: BUDHU, ANURADHA  (contact)

PROJECT_TERMS: 3-Dimensional;Affect;African American population;anti-cancer research;Area;arm;Artificial Intelligence;BAY 54-9085;biliary tract;Bioinformatics;bioinformatics tool;Biological Markers;Biological Products;Biopsy Specimen;Blood;cancer clinical trial;capecitabine;Carcinoma;CCR;Cells;Cholangiocarcinoma;Clinical;clinical center;Clinical Data;clinical efficacy;Clinical Trials;Collaborations;Communities;Computational Biology;Data;Data Science;Data Set;Development;Diagnosis;DNA sequencing;Early Diagnosis;effective therapy;Elements;Environment;exome sequencing;Extramural Activities;Fellowship;Formalin;Foundations;Funding;Future;Genomics;Goals;health disparity;Heterogeneity;Hispanic Populations;Image Analysis;immune cell infiltrate;Immune checkpoint inhibitor;Immunophenotyping;Immunotherapy;improved;Individual;Infrastructure;insight;Institution;Intramural Research;Laboratories;Lead;liver cancer patient;liver development;Liver neoplasms;Machine Learning;Malignant neoplasm of liver;Malignant Neoplasms;Medical;Medicine;metabolomics;microbiome;Microscopy;Mission;Molecular;Molecular Profiling;molecular targeted therapies;multidisciplinary;Multimodal Imaging;multiplexed imaging;Mutation;Nature;neoplastic cell;new therapeutic target;novel;novel therapeutics;Oncologist;Optics;optimism;Outcome;oxaliplatin;Paraffin Embedding;participant enrollment;Patient Monitoring;patient response;patient subsets;Patient-Focused Outcomes;Patients;pembrolizumab;phase 2 study;phase 3 study;Pilot Projects;Positioning Attribute;precision medicine;predictive signature;prevent;Prevention;Prevention approach;Primary carcinoma of the liver cells;Primary Malignant Neoplasm of Liver;programs;prospective;Publishing;Race;Radiogenomics;Refractory;Relapse;Reporting;Research;Research Activity;Research Personnel;Resistance development;Resources;responders and non-responders;response;Retrospective Studies;Role;Sampling;single cell sequencing;Site;standard of care;statistical and machine learning;Subgroup;success;synergism;Testing;Tissue Embedding;Tissues;Training;Training and Education;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Translational Research;Treatment outcome;treatment responders;treatment response;tumor;United States National Institutes of Health;Universities;Urine;Validation;Variant;Vision

PROJECT_TITLE: Liver Cancer Program


NIH_SPENDING_CATS: Cancer;Clinical Research;Palliative Care;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PI_NAMEs: WIENER, LORI  (contact)

PROJECT_TERMS: 12 year old;17 year old;7 year old;Address;Adolescent;Adult;Affect;Age;age group;Child;Childhood;Chronic Disease;chronic graft versus host disease;Clinical Trials;cognitive interview;Companions;Comprehension;Consensus;Data;design;Development;Disabling;Enrollment;Extramural Activities;Eye;Face;Genetic Diseases;graft vs host disease;Hematopoietic Stem Cell Transplantation;Immunosuppression;improved;instrument;Intestines;Judgment;Liver;Lung;Malignant Childhood Neoplasm;Measures;Musculoskeletal System;Oral cavity;Organ;Outcome Measure;Pain;Parents;Participant;Patient Outcomes Assessments;Patients;pediatric patients;Population;Procedures;Proxy;Psychometrics;psychosocial;Recommendation;Respondent;response;Sampling;Severities;Severity of illness;side effect;Site;Skin;Standardization;Stem cell transplant;Steroids;symptom management;Symptoms;Testing;transplant survivor;Transplantation;United States National Institutes of Health

PROJECT_TITLE: Graft-Versus-Host Disease Symptom Management-Cures


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Rare Diseases

PI_NAMEs: YANG, CHUN ZHANG  (contact)

PROJECT_TERMS: Adopted;Animal Model;Biological;CRISPR/Cas technology;Disease Outcome;DNA cassette;Future;Gene Expression;gene-editing approach;Genes;Genetic;Genome;Gifts;Glioma;Guide RNA;Human;in vivo;in vivo Model;Investigation;knock-down;Modeling;mouse genome;mouse model;Mus;mutant;Mutate;Plasmids;Pre-Clinical Model;receptor;System;Transgenes;Translational Research;tumor;vector;Virus

PROJECT_TITLE: Establish Preclinical Model for IDH-mutated Glioma


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Immunization;Immunotherapy;Neurosciences;Rare Diseases;Vaccine Related

PI_NAMEs: TERABE, MASAKI  (contact)

PROJECT_TERMS: adaptive immunity;Affect;Aggressive course;analog;anti-tumor immune response;Antigen-Presenting Cells;Antigens;Astrocytes;Atlases;Binding;Brain;cancer type;Cell Communication;Cell Line;Cell Physiology;Cells;Characteristics;chemoradiation;Chemotaxis;Chinese;Clinical;clinical efficacy;Combined Modality Therapy;cytokine;Data;Data Set;design;Diagnosis;disease prognosis;Environment;Flow Cytometry;Frequencies;genetic signature;Genome;Glioblastoma;Glioma;glioma cell line;Glycolipids;granulocyte;Human;Iatrogenesis;Immune;Immune checkpoint inhibitor;Immune response;Immune system;Immunologics;immunoregulation;Immunosuppression;Immunotherapy;improved;in vivo;insight;invention;Leukocytes;lipid metabolism;Lipids;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;Modeling;Mus;Mutation;Myeloid Cells;Myeloid-derived suppressor cells;Natural Immunity;neoantigens;neoplastic cell;Normal Cell;novel;novel strategies;Operative Surgical Procedures;Outcome;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;Play;Preventative vaccination;Primary Brain Neoplasms;Production;programs;protective effect;PTPRC gene;Published Comment;Reporting;Research;response;Role;Sampling;Signal Transduction;single-cell RNA sequencing;Structure;Sulfoglycosphingolipids;T memory cell;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Testing;The Cancer Genome Atlas;Therapeutic;Tissue Sample;Tissues;trafficking;Transcript;transcriptomics;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;Tumor Tissue;tumor-immune system interactions;vaccination strategy;vaccine efficacy;Vaccines;vector;vector-based vaccine;Viral Vector

PROJECT_TITLE: Immunological Analysis of Brain Cancer


PI_NAMEs: CHEN, CHONGYI  (contact)

PROJECT_TERMS: Biological Process;Cells;Cellular Assay;Chromatin;Chromatin Structure;DNA Topoisomerases;Gene Expression;Gene Expression Regulation;Genes;genome-wide;Genomic Instability;Genomics;Goals;Human;Human Genome;Nuclear;Process;Regulation;Role;Superhelical DNA;Technology;Topoisomerase;Transcriptional Regulation

PROJECT_TITLE: The dynamics of chromatin topology in human cells


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

PI_NAMEs: ALEWINE, CHRISTINE  (contact)

PROJECT_TERMS: Affect;American Association of Cancer Research;Angiogenesis Inhibitors;Animal Model;Biopsy;Biopsy Specimen;Blood Vessels;cell killing;Cells;clinical center;Clinical Research;cohort;Combined Modality Therapy;Correlative Study;Cytotoxin;Data;density;Dose;Drug Kinetics;Elements;Endothelial Cells;Extramural Activities;Fibroblasts;first-in-human;Growth;Human;improved outcome;Integrin alphaVbeta3;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;Manuscripts;mouse model;Mus;Neoplasm Metastasis;novel;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Patients;Pharmaceutical Preparations;Phase;preclinical study;Protein Engineering;rational design;Safety;safety testing;Sampling;Solid Neoplasm;Structure;symposium;Testing;Therapeutic;therapy resistant;Time;tumor;tumor growth;United States National Institutes of Health;Work

PROJECT_TITLE: First in Human Trials of ProAgio, a Cytotoxin


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Digestive Diseases - (Gallbladder);Genetics;Human Genome;Immunotherapy;Liver Cancer;Liver Disease;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: XIE, CHANGQING  (contact)

PROJECT_TERMS: bile duct;cancer cell;cancer stem cell;cancer type;Cell Reprogramming;Cells;Cholangiocarcinoma;cohort;Collecting Cell;Data;Diagnosis;experimental study;Gene Expression Profile;Heterogeneity;Immune;Immunotherapy;In Vitro;in vivo;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;mouse model;Mus;Prognosis;programs;Proto-Oncogene Proteins c-akt;Reporting;Resistance;Resolution;Resources;RNA analysis;single-cell RNA sequencing;standard of care;stem-like cell;stemness;Stromal Cells;The Cancer Genome Atlas;transcriptome sequencing;transcriptomics;tumor microenvironment;tumorigenesis

PROJECT_TITLE: Cancer Stem Cells in Cholangiocarcinoma


NIH_SPENDING_CATS: Cancer;Immunotherapy

PI_NAMEs: JIANG, PENG  (contact)

PROJECT_TERMS: anti-tumor immune response;Antigens;Atlases;cancer immunotherapy;Clinical;computational platform;Computer Models;cytokine;Data;density;effectiveness validation;Enhancers;Exclusion;Exhibits;experimental study;Genes;Human;Immune;immune checkpoint blockade;Immunooncology;Immunotherapy;Inferior;Knowledge;Lecithin;Mediating;Modeling;Mus;Protein Secretion;Proteins;Research;Resistance;Resources;Role;T-Cell Activation;tumor;Tumor Escape;Tumor-Secreted Protein

PROJECT_TITLE: Data-driven inference of regulators for cytokine-mediated tumor killing


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Immunotherapy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: anti-PD-1;Biological;cancer immunotherapy;cancer type;Cells;Characteristics;Clinical;Clinical Research;Code;cohort;computer framework;convolutional neural network;CTLA4 gene;Data;Gene Expression;Genes;genome-wide;human data;Human Genome;Image;imaging Segmentation;Imaging technology;Immunotherapy;in vivo;Individual;information organization;intercellular communication;Label;Learning;Malignant Neoplasms;Maps;Mediating;Methodology;Methods;mouse model;multi-scale imaging data;Patients;Phase;Physiological;Prognosis;Protein Analysis;protein biomarkers;Protein Secretion;Proteins;Proteomics;Sampling;Signaling Protein;Source;Spottings;Structure;Technology;Tissue imaging;Tissues;Training;transcriptomics;tumor

PROJECT_TITLE: Computational approaches for the analyses of spatial profiling technologies


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Neuroblastoma;Neurofibromatosis;Neurosciences;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Skin Cancer

PROJECT_TERMS: Acute Lymphocytic Leukemia;Acute Myelocytic Leukemia;Adult;arm;Benign;Binding;Biological;BRAF gene;Candidate Disease Gene;CBL gene;Childhood;Childhood Melanoma;Childhood Solid Neoplasm;Clinical;clinical efficacy;Clinical Trials;cohort;Collaborations;Data Analyses;design;Development;driver mutation;Drug Combinations;Drug Targeting;Embryonal Rhabdomyosarcoma;Eosinophilic Granuloma;Extracellular Signal Regulated Kinases;Farnesyl Transferase Inhibitor;FDA approved;Future;Genomics;Glioma;Guanine Nucleotides;Hematologic Neoplasms;Histology;Human;improved;inhibitor;Juvenile Myelomonocytic Leukemia;KRAS2 gene;Lead;loss of function mutation;Malignant - descriptor;Malignant Childhood Neoplasm;Malignant Neoplasms;MAP Kinase Gene;MEKs;Membrane;Methods;Modeling;Molecular Target;mutant;Mutate;Mutation;Neuroblastoma;Neurofibromatosis 1;Neurofibrosarcoma;Nevus;NF1 gene;novel;novel drug class;novel drug combination;objective response rate;Oncogenic;Oncoproteins;Pathway interactions;Patients;Pediatric Hematology;Pediatric Neoplasm;Phase;Phase II Clinical Trials;PI3K/AKT;Pilocytic Astrocytoma;Plexiform Neurofibroma;prenylation;prevent;primary endpoint;Protein Isoforms;PTPN11 gene;RAF1 gene;RAS genes;ras GTPase-Activating Proteins;Ras Inhibitor;ras Proteins;Ras/Raf;Relapse;Research Design;Research Personnel;Resistance;Rhabdomyosarcoma;Signal Transduction;Solid Neoplasm;Somatic Mutation;specific biomarkers;targeted agent;Testing;Tipifarnib;Translating;tumor;tumor growth;Work;Xenograft Model

PROJECT_TITLE: Targeting RAS in Pediatric Cancer


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Neurosciences;Radiation Oncology;Sleep Research

PI_NAMEs: ARMSTRONG, TERRI S. (contact)

PROJECT_TERMS: Animals;Behavior;behavior measurement;Behavioral;Behavioral Model;Biological;Blood;C57BL/6 Mouse;Central Nervous System;Central Nervous System Neoplasms;Cognition;Computer software;Cranial Irradiation;Darkness;Data;Data Analyses;Dose;early onset;Eating;experience;experimental study;Exposure to;Foundations;Genes;Genetic Polymorphism;Goals;Graph;Grooming;Hour;Human;Hypersomnias;Hypersomnolence;Individual;irradiation;Light;Low Dose Radiation;male;Monitor;mouse model;Mus;Natural History;Patients;Phase;Pre-Clinical Model;Procedures;Quality of life;Radiation;Radiation Dose Unit;radiation effect;Radiation therapy;Rest;Rodent;Sleep;sleep behavior;standard of care;Symptoms;System;Testing;Time;Translations;Travel;tumor;Walking;Work

PROJECT_TITLE: Behavioral Correlates in Mouse Model of CNS radiation-induced hypersomnia


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Infectious Diseases;Rare Diseases;Skin Cancer;Urologic Diseases

PI_NAMEs: STARRETT, GABRIEL  (contact)

PROJECT_TERMS: 3-Dimensional;Affect;anti-cancer research;Biology;Bladder;Bone Marrow Transplantation;cancer type;carcinogenicity;Cell Line;Cell model;Cells;Chromatin;Chromatin Loop;Clinical;clinically relevant;conditioning;Cystitis;Data;Data Analyses;Development;Disease;Dose;Engineering;Enzymes;Epidemiology;Epigenetic Process;Etiology;Event;Evolution;experimental study;Gene Expression;Genetic Transcription;Genome;genome sequencing;Genome Stability;Goals;Hemorrhage;Immune;Immunocompromised Host;Infection;knock-down;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Manuscripts;Merkel cell carcinoma;Metabolism;Methods;Modeling;Molecular Conformation;Morphology;Mutagenesis;Mutagens;Mutation;novel;Oncogenic Viruses;Pathologic Mutagenesis;Patients;Pharmaceutical Preparations;Polyomavirus;Polyomavirus Infections;Preparation;Prevention;Process;prospective;Risk;Sebaceous Gland Neoplasms;Somatic Mutation;Specimen;Techniques;tissue archive;Tissues;transcriptome sequencing;Transplant Recipients;Tumor Biology;tumorigenesis;urinary;Urothelial Cell;Urothelium;Viral;viral DNA;Viral Oncogene;Virus;Virus Diseases;Virus Integration;virus related cancer;whole genome;Work

PROJECT_TITLE: Biology of Virus-associated Cancers


NIH_SPENDING_CATS: Cancer;Patient Safety;Prostate Cancer;Urologic Diseases

PI_NAMEs: LIN, FRANK  (contact)

PROJECT_TERMS: Calendar;Collaborations;Enrollment;FOLH1 gene;Future;Human;improved;industry partner;Institutional Review Boards;participant enrollment;Pharmaceutical Preparations;Pharmacologic Substance;Process;prostate cancer cell;Radiation Dose Unit;radioligand;Radiopharmaceuticals;side effect;Site;Testing;tumor;United States National Institutes of Health

PROJECT_TITLE: Improving PSMA-based radioligand therapy via combination radioligand therapy


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Prostate Cancer;Urologic Diseases

PI_NAMEs: MADAN, RAVI  (contact)

PROJECT_TERMS: Agreement;Androgen Antagonists;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Area;Biochemical;Clinical Trials;Combination immunotherapy;Development;enzalutamide;Evaluation;FOLH1 gene;follow-up;Goals;Image;Immune;Immunologics;Immunotherapy;Industry;inhibitor;Malignant neoplasm of prostate;Nonmetastatic;novel;Pathway interactions;patient subsets;Patients;Population;Positron-Emission Tomography;Prostate;Protocols documentation;Quality of Life Assessment;Radiation;Radiopharmaceuticals;Recurrence;Reporting;response;Science;Vaccines

PROJECT_TITLE: Evaluation of novel treatments in biochemically recurrent prostate


NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunization;Immunotherapy;Prostate Cancer;Urologic Diseases;Vaccine Related

PROJECT_TERMS: Biochemical;Cancer Vaccines;chemotherapy;Clinical Trials;Combination immunotherapy;docetaxel;Evaluation;FOLH1 gene;Immune;Immune checkpoint inhibitor;Immune response;Immunotherapy;improved;Malignant neoplasm of prostate;Metastatic/Recurrent;Necrosis;novel;phase 1 study;phase 2 testing;Positron-Emission Tomography;Progression-Free Survivals;Radiation;Recurrence;Safety;serum PSA;synergism;therapeutic evaluation;Toxic effect;vaccine strategy;Work

PROJECT_TITLE: Evaluation of Immune-based Combinations in Prostate Cancer


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Neurosciences

PI_NAMEs: SADOWSKI, SAMIRA  (contact)

PROJECT_TERMS: Affinity;analog;Award;Bees;Cancer Model;Cells;Characteristics;Clinical Trials;Collaborations;Detection;Development;Diagnostic Imaging;differential expression;Disseminated Malignant Neoplasm;Epigenetic Process;Excision;Goals;Growth;Histone Deacetylase Inhibitor;imaging agent;Industry;interest;Laboratories;Learning;Ligand Binding;Malignant Neoplasms;Modeling;Mus;Neoplasm Metastasis;neuroendocrine cancer;Neuroendocrine Tumors;novel;Operative Surgical Procedures;Organoids;Pathway interactions;Patients;Peptides;Pharmaceutical Preparations;Positron-Emission Tomography;Radio;Radiolabeled;receptor;Regulation;Somatostatin Receptor;somatostatin receptor 1;SSTR2 gene;Surface;targeted treatment;tumor;Tumor Escape;Up-Regulation;Work

PROJECT_TITLE: Targeted Therapy in Neuroendocrine Cancer


PI_NAMEs: RAJAN, ARUN  (contact)

PROJECT_TERMS: B-Lymphocytes;CD4 Positive T Lymphocytes;Correlative Study;Dendritic Cells;Disease;Enrollment;Immune;immune-related adverse events;objective response rate;Participant;Patients;Pilot Projects;Recurrence;Refractory;Relapse;Safety;T-Lymphocyte;Thymic Carcinoma;Thymoma;Thymus Epithelial Neoplasm;Thymus Neoplasms

PROJECT_TITLE: Pilot Study of Avelumab in Thymic Epithelial Tumors


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Regenerative Medicine

PI_NAMEs: LEBENSOHN, ANDRES  (contact)

PROJECT_TERMS: Adherens Junction;Adult;Animal Model;Animals;APC gene;Apoptosis;beta catenin;Biochemical;Biochemical Reaction;Biological;Biological Process;cancer type;Cardiovascular Diseases;casein kinase;Cell Communication;Cell Cycle Arrest;Cell Physiology;Cell-Cell Adhesion;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Colorectal Cancer;comparative;Complex;Cues;Defect;Dental;Development;Diabetes Mellitus;Disease;Down-Regulation;Embryo;Embryonic Development;Endowment;Epithelium;Equilibrium;Evolution;FDA approved;forward genetics;gastric cancer cell;Genes;genetic analysis;Genetic Screening;genome wide screen;Goals;Haploidy;Helix-Turn-Helix Motifs;Human;Hyperactivity;Inhibition of Cell Proliferation;Instruction;Leucine Zippers;Life;Ligands;Link;malformation;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Mediating;Mediator;Mesenchymal;migration;Molecular;Morphogenesis;Mutate;Natural regeneration;Neoplasm Metastasis;Neurodegenerative Disorders;Oncogenic;Organ;Organism;Organoids;Outcome;Pathway interactions;Pattern;Pharmaceutical Preparations;Phosphotransferases;Physiological;Process;programs;Proteins;Regulation;Regulatory Element;Reporter;Research;Role;self-renewal;Signal Induction;Signal Pathway;Signal Transduction;skeletal;stem cells;Therapeutic;therapeutic target;tissue regeneration;Tissues;Transcription Coactivator;transcription factor;Transcriptional Activation;tumor;ubiquitin ligase;Ubiquitination;WNT Signaling Pathway;Xenopus laevis;zygote

PROJECT_TITLE: New regulatory mechanisms of WNT signaling in development, stem cells and cancer


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Neurodegenerative;Neurosciences;Peripheral Neuropathy

PROJECT_TERMS: Adverse event;Antibody-drug conjugates;Clinical Trials;Cornea;Development;Disease;efficacy evaluation;experience;In complete remission;Interruption;mesothelin;Multicenter Trials;neoplastic cell;objective response rate;Patients;Peripheral Nervous System Diseases;preclinical study;Thymic Carcinoma

PROJECT_TITLE: Anetumab in Thymic Carcinoma


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Immunization;Orphan Drug;Ovarian Cancer;Rare Diseases;Vaccine Related;Women's Health Research

PI_NAMEs: TANNER, KANDICE  (contact)

PROJECT_TERMS: Antigens;Bacteria;Bacterial Spores;Binding;biomaterial compatibility;cancer cell;Cancer Vaccines;Cell surface;cell type;chemotherapeutic agent;Clinical;combinatorial;Cytosol;delivery vehicle;Doxorubicin;Drug Delivery Systems;Drug Targeting;Epitopes;ERBB2 gene;Goals;In Vitro;interest;Liposomal Doxorubicin;Malignant neoplasm of ovary;Malignant Neoplasms;Metastatic malignant neoplasm to brain;Modeling;Mus;Normal Cell;overexpression;particle;Patients;Peptides;Pharmaceutical Preparations;Phospholipids;Prognosis;Proteins;reconstitution;Reporting;Reproduction spores;side effect;Silicon Dioxide;small molecule;small molecule therapeutics;synthetic construct;System;targeted delivery;Testing;Therapeutic;Thick;Toxic effect;tumor;tumor eradication;tumor growth;tumor xenograft;vaccine platform;Work;Xenograft Model;Zebrafish

PROJECT_TITLE: Synthetic bacteria as a targeted delivery system for small molecule therapeutics


PI_NAMEs: WILSON, BRICE  (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;anti-cancer research;assay development;bioactive natural products;Biochemical;Biochemistry;Biological;Biological Assay;Biological Models;Biology;Biophysics;Cells;Chemicals;Chemistry;Collaborations;Communicable Diseases;cytotoxicity;design;Development;Disease;DNA Repair Enzymes;drug discovery;Evaluation;Extramural Activities;FOXO1A gene;Future;high throughput screening;HIV;Information Technology;inhibitor;Intramural Research Program;Investments;Laboratories;Libraries;Malignant Epithelial Cell;Malignant neoplasm of prostate;Malignant Neoplasms;Molecular Biology;Molecular Target;Natural product discovery;Natural Products;Natural Products Chemistry;NCI Center for Cancer Research;neurodevelopment;novel;novel therapeutics;Oncogenic;Output;pandemic disease;Pathway interactions;PAX3 gene;Phenotype;Phosphotransferases;Pleural Mesothelioma;Principal Investigator;PRKACA gene;Productivity;programs;Protein Chemistry;Proteins;Publications;Reporting;repository;Research;Research Personnel;Science;Scientist;screening;Technology;transcription factor;translational applications;translational potential;Translational Research;United States National Institutes of Health;Untranslated RNA;Virus;Virus Diseases;Work

PROJECT_TITLE: Assay development and screening for molecular targets and discovery


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Lung;Lung Cancer

PROJECT_TERMS: Antibodies;cancer biomarkers;Clinical;cohort;Combination immunotherapy;Correlative Study;Drug usage;Enrollment;Evaluation;immune activation;Monoclonal Antibodies;Non-Small-Cell Lung Carcinoma;Paper;participant enrollment;patient subsets;Patients;phase I trial;programmed cell death ligand 1;Publishing;response;Sampling;Signal Transduction;Solid Neoplasm;TGFB1 gene;Toxic effect

PROJECT_TITLE: Anti-PD-L1-TGFb antibody (M7824) in advanced Non-Small Cell Lung Cancer


PROJECT_TERMS: anti-PD1 therapy;Carcinoembryonic Antigen;chemotherapy;Dose;Immunotherapy;Intercellular adhesion molecule 1;Lymphocyte Function-Associated Antigen-1;Malignant neoplasm of lung;Modified Vaccinia Virus Ankara;Mucin 1 protein;Nivolumab;Non-Small-Cell Lung Carcinoma;Patients;pembrolizumab;Platinum;Poxviridae;Publishing;Recurrence;safety assessment;Transgenes;vector

PROJECT_TITLE: CV301 and Anti-PD-1 Therapy in Non-Small Cell Lung Cancer


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Lung;Lung Cancer

PROJECT_TERMS: Clinical;cohort;Complement;DNA Damage;Enrollment;Immune checkpoint inhibitor;Immunologics;Immunotherapy;Individual;Measures;Monoclonal Antibodies;Non-Small-Cell Lung Carcinoma;PARP inhibition;Patients;phase II trial;Poly(ADP-ribose) Polymerase Inhibitor;predictive marker;programmed cell death ligand 1;Progression-Free Survivals;Recurrence;Signal Transduction;Toxic effect;tumor

PROJECT_TITLE: Durvalumab in Combination with Olaparib in Non-Small Cell Lung Cancer


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;HIV/AIDS;Hematology;Human Genome;Lymphatic Research;Lymphoma;Orphan Drug;Precision Medicine;Rare Diseases

PI_NAMEs: ROSCHEWSKI, MARK  (contact)

PROJECT_TERMS: B-Cell Lymphomas;Biological Assay;Biopsy;Burkitt Lymphoma;cancer cell;Cells;Clinical;Clonal Evolution;detection method;Diagnosis;Disease Progression;Disease remission;Follicular Lymphoma;Gene Expression Profile;Genotype;Goals;high risk;Histologic;Human Herpesvirus 4;Immune;Immune Response Genes;improved;large cell Diffuse non-Hodgkin's lymphoma;Lymphoma;Mantle Cell Lymphoma;Molecular;Molecular Biology;Molecular Profiling;new therapeutic target;Non-Malignant;Patients;Positron-Emission Tomography;precision medicine;predicting response;predictive signature;Recurrent disease;resistance mechanism;response;Role;Systemic Therapy;targeted agent;Techniques;Time;Tissues;transcriptome sequencing;treatment response;tumor DNA

PROJECT_TITLE: Molecular Biology of Lymphoma


NIH_SPENDING_CATS: Cancer;Clinical Research;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Rare Diseases

PROJECT_TERMS: Agammaglobulinaemia tyrosine kinase;B-Cell Lymphomas;Central Nervous System Lymphoma;design;Disease remission;efficacy evaluation;Gene Expression Profile;Immune checkpoint inhibitor;In complete remission;Industry Collaboration;inhibitor;large cell Diffuse non-Hodgkin's lymphoma;Legal patent;Lymphoma;manufacture;Molecular;Pathway interactions;Patients;PIK3CG gene;predictive signature;Refractory;Relapse;Resistance;response;rituximab;Signal Transduction;Toxic effect;treatment strategy;tumor;Tyrosine Kinase Inhibitor

PROJECT_TITLE: Pathway inhibitors in Lymphomas


NIH_SPENDING_CATS: Cancer;Genetics;Human Genome;Prevention;Prostate Cancer;Urologic Diseases

PI_NAMEs: KELLY, KATHLEEN  (contact)

PROJECT_TERMS: Adenocarcinoma;Biological;Castration;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR screen;design;Differentiation and Growth;Dominant-Negative Mutation;Dropout;Epigenetic Process;Genes;Genetic Predisposition to Disease;Growth;in vivo;LNCaP;Malignant neoplasm of prostate;Malignant Neoplasms;Mediator;Methodology;Modeling;Neoplasm Metastasis;Neuroendocrine Prostate Cancer;Neurosecretory Systems;Null Lymphocytes;Organoids;Patients;Process;RB1 gene;Resistance;screening;therapeutic target;TP53 gene;transdifferentiation;Work

PROJECT_TITLE: Identifying genetic vulnerabilities in neuroendocrine prostate cancer


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Digestive Diseases;Immunotherapy;Kidney Disease;Orphan Drug;Pancreatic Cancer;Rare Diseases

PI_NAMEs: SRINIVASAN, RAMAPRASAD  (contact)

PROJECT_TERMS: Accounting;American Association of Cancer Research;American Society of Clinical Oncology;anti-cancer research;bHLH-PAS factor HLF;cancer subtypes;Central Nervous System Neoplasms;Clear Cell;Clinical Research;Data;design;Development;Disease;Evaluation;follow-up;Genes;Genetic Transcription;Germ Lines;Grant;Growth Factor Gene;hemangioblastoma;Hypoxia Inducible Factor;Immunotherapy;In complete remission;inhibitor;Islet Cell Tumor;Journals;Kidney Neoplasms;Malignant Neoplasms;Manuscripts;Mediating;Medicine;meetings;mutant;New England;novel;novel strategies;Ophthalmology;Organ;Outcome;Oxygen;pancreatic neoplasm;participant enrollment;Pathway interactions;Patients;PD-1 inhibitors;PD-1/PD-L1;pharmacologic;Phase;phase 2 study;Proteins;Publishing;Renal Carcinoma;Renal Cell Carcinoma;Reporting;Resistance;Resistance development;response;Retina;Safety;small molecule inhibitor;standard care;targeted agent;targeted treatment;therapy resistant;Time;translational pipeline;tumor;tumor microenvironment;Up-Regulation;Update;Vascular Endothelial Growth Factors;VHL mutation;Work

PROJECT_TITLE: Novel Approaches to Targeting Cancers Associated with VHL Mutations


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Clinical Research;Gene Therapy;Genetics;HIV/AIDS;Hematology;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: TAYLOR, NAOMI  (contact)

PROJECT_TERMS: Adoptive Immunotherapy;alpha ketoglutarate;Antigens;B-Cell Acute Lymphoblastic Leukemia;cancer cell;Cancer Cell Growth;CCR;CD19 gene;CD22 gene;Cell Physiology;Cells;Characteristics;Childhood;Childhood Leukemia;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clinical Trials;Collaborations;computational pipelines;cytokine;Cytokine Receptors;Data;Diffuse;Disseminated Malignant Neoplasm;effector T cell;efficacy evaluation;Engineering;Environment;Equilibrium;Evaluation;extracellular;Generations;Glutamine;Goals;high risk;Immune;Immune response;Immunotherapeutic agent;Immunotherapy;In Vitro;Infusion procedures;interest;Investments;leukemia;Lymphoma;manufacture;Metabolic;Metabolism;Modeling;neoplasm immunotherapy;novel;novel strategies;Nutrient;Oxygen;Patient-Focused Outcomes;Patients;Phase;Phase I/II Clinical Trial;Phenotype;polarized cell;Process;Protocols documentation;Reaction Time;real time monitoring;receptor;Refractory;Regulatory T-Lymphocyte;Relapse;response;success;Surface;System;T cell differentiation;T cell regulation;T cell response;T cell therapy;T-Lymphocyte;Therapeutic;Time;TSLP gene;tumor;Tumor Antigens;tumor microenvironment;Tumor Tissue;United States National Institutes of Health;Universities;Variant;Waste Products

PROJECT_TITLE: Metabolic regulation of T cell effector function and anti-tumor immunotherapy


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Hematology;Orphan Drug;Pediatric;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PROJECT_TERMS: acquired immunodeficiency;Architecture;Arginine;Biogenesis;Blood;Bone Marrow;Cell Differentiation process;Cell Lineage;Cell Maintenance;Cell Physiology;cell regeneration;Cells;Compensation;congenital immunodeficiency;Cyclic Nucleotides;Cyclophosphamide;cytokine;Defect;Diamond-Blackfan anemia;Disease;DNA;Dysmyelopoietic Syndromes;engineered T cells;Equilibrium;Erythrocytes;Erythroid;erythroid differentiation;Erythropoiesis;Gene Proteins;Gene Transfer;Generations;Genes;Genetic Recombination;Genetic study;Glucose;Glutamine;Glycolysis;hematopoietic stem cell differentiation;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Home;Human;improved;in vivo;Individual;Kinetics;Length;loss of function mutation;Lymphoid;Lymphoid Cell;Lysine;Macaca;Mediating;Metabolic;Metabolism;migration;Mitochondria;Mus;Mutation;Myelogenous;novel;novel therapeutics;Nucleoside Transporter;Nucleotide Biosynthesis;Nucleotides;Nutrient;Oxidative Phosphorylation;Pathologic;Pathway interactions;Patients;Post-Translational Protein Processing;post-transplant;progenitor;programs;Proliferating;Protein Array;protein transport;Proteins;reconstitution;Regulation;Research;Resources;Ribosomal Proteins;Role;Secondary to;self-renewal;Signal Induction;Specific qualifier value;Spermidine;stem cell division;Stem cell transplant;stem cells;stemness;Supporting Cell;T cell differentiation;T cell reconstitution;T-Cell Development;T-Lymphocyte;Therapeutic;Thymus Gland;Time;translation factor;Translations;Transplantation

PROJECT_TITLE: Metabolic programs regulating hematopoietic stem cell differentiation


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Hematology;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PI_NAMEs: SHAH, NIRALI  (contact)

PROJECT_TERMS: Acute leukemia;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Adolescent and Young Adult;Adoptive Cell Transfers;Adult Acute Myeloblastic Leukemia;Allogenic;Amendment;Antigen Targeting;Antigens;arm;Autologous;B lymphoid malignancy;B-Cell Acute Lymphoblastic Leukemia;B-Lymphocytes;Back;bench to bedside;Biological;Biological Products;Blood;Bone Marrow Transplantation;CAR T cell therapy;CD22 gene;Cell Therapy;Cells;cellular engineering;chemotherapy;Child;Childhood;chimeric antigen receptor T cells;Clinical;clinical center;clinical translation;Clinical Trials;clinically relevant;cohort;Collaborations;combinatorial;Country;Data;design;Development;Disease remission;Disease-Free Survival;donor stem cell;Dose;early phase clinical trial;Engraftment;Enrollment;Evaluable Disease;experience;FLT3 gene;Foundations;Functional disorder;Future;Generations;Goals;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;Hemophagocytic Lymphohistiocytoses;high risk;IL3RA gene;Immunotherapeutic agent;Immunotherapy;improved;improved outcome;Incidence;Inflammatory;Infrastructure;Infusion procedures;insight;international center;Investigation;leukemia;Licensing;manufacture;Marrow;Maximum Tolerated Dose;Mediating;meetings;mesothelin;Mission;Monitor;Morphology;mortality;multidisciplinary;Myeloid Leukemia;Myeloproliferative disease;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Outcome;Patient-Focused Outcomes;Patients;Pediatric Oncology;pediatric patients;Phase;Phase I/II Trial;Population;post-transplant;Process;Program Development;programs;protocol development;Refractory;Relapse;Research;Resistance;response;Risk Factors;risk mitigation;safety and feasibility;Scientific Advances and Accomplishments;Services;Severities;Siblings;Stem cell transplant;Syndrome;T-Lymphocyte;Testing;Therapeutic;Therapeutic Index;Toxic effect;transplantation therapy;trial design;United States National Institutes of Health;vector;Vision;Work;young adult

PROJECT_TITLE: Development of Novel Immunotherapeutic Strategies for Myeloid Malignancies


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Kidney Disease;Rare Diseases;Urologic Diseases

PI_NAMEs: APOLO, ANDREA  (contact)

PROJECT_TERMS: Adenocarcinoma;Affect;Bladder;Bladder Adenocarcinoma;Bladder Carcinoma;Bladder Squamous Cell Carcinoma;bone;cancer type;Carcinoma;Caring;Clinical;Clinical Research;Clinical Trials;cohort;Collecting Ducts of Bellini Carcinoma;Country;Data;Data Pooling;Disease;Duct (organ) structure;exome sequencing;Genitourinary system;Histologic;Histology;Human;Immune;Incidence;Individual;ipilimumab;Literature;Malignant neoplasm of penis;Malignant neoplasm of testis;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mutation;Nivolumab;Patients;Penis carcinoma;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Phase;phase 1 study;phase 2 study;rare cancer;Rare Diseases;recruit;Renal Carcinoma;Resources;response;Science;Skin Appendage Carcinoma;Small Cell Carcinoma;Squamous cell carcinoma;transcriptome sequencing;Transitional Cell Carcinoma;tumor;Tumor Expansion;United States National Institutes of Health;Urethra;Urogenital Cancer;urogenital tract;Variant

PROJECT_TITLE: Rare genitourinary tumors projects


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Coronaviruses;Data Science;Emerging Infectious Diseases;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pneumonia;Pneumonia and Influenza

PI_NAMEs: WOOD, BRADFORD J (contact)

PROJECT_TERMS: 3D Print;air filtration;Artificial Intelligence;artificial intelligence model;automated segmentation;Bacterial Pneumonia;Biopsy;Breathing;CCR;Cellular Phone;Characteristics;Chest imaging;Classification;Clinical;Clinical Trials;commercialization;Communities;COVID-19;crosslink;cytokine;Data;Data Aggregation;data curation;Data Set;Databases;deep learning;deep learning model;Detection;Development;Devices;Disease;Disease Outbreaks;Epidemiology;Exercise;Extramural Activities;Family suidae;federated learning;flu;Goals;Health;Healthcare;Hearing Tests;Image;image guided;image guided therapy;imaging modality;Immunology;Industry;industry partner;Infection;Influenza;Interventional radiology;Journals;Laboratories;large language model;Licensing;Liver;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Medical Imaging;medical specialties;Medicine;member;Methodology;minimally invasive;Modeling;multimodality;National Institute of Allergy and Infectious Disease;Nature;nonhuman primate;Organ;Outcome;pandemic disease;Pathway interactions;Performance;Phenotype;pre-clinical;Procedures;Publications;Radiology Specialty;Research;Resource-limited setting;Resources;respiratory;response;screening;sensor;Signal Transduction;Skin;smartphone application;Source;Spirometry;Standardization;Techniques;The Cancer Imaging Archive;Thermal Ablation Therapy;tool;Translating;tumor;United States National Institutes of Health;Validation;Ventilator;Viral Pneumonia;Voice;wearable data;wearable sensor technology;web app;web site;Work;X-Ray Computed Tomography

PROJECT_TITLE: Development of COVID-19 and Cancer Tools with Artificial Intelligence


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Cancer;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Precision Medicine;Prevention;Vaccine Related

PI_NAMEs: FELBER, BARBARA K (contact)

PROJECT_TERMS: 2019-nCoV;adaptive immune response;adaptive immunity;anakinra;Anti-Inflammatory Agents;Antibodies;Antigens;B-Lymphocytes;Binding;Biological Markers;Biology;Cancer Patient;CCL2 gene;CCL22 gene;CCL3 gene;CCL4 gene;CCL8 gene;Cells;chemokine;cohort;COVID-19;COVID-19 vaccination;COVID-19 vaccine;CXCL10 gene;CXCL13 gene;CXCR3 gene;cytokine;Data;Development;Disease;Early identification;Effectiveness;Goals;Hematologic Neoplasms;high risk;HIV vaccine;Humoral Immunities;IL16 gene;IL8 gene;Immune;Immune response;Immunity;Immunocompromised Host;Immunologic Markers;Individual;individual patient;Infection;Inflammatory;Innate Immune Response;Interferon Type II;Interleukin-15;Interleukin-16;Interleukin-6;Internships;Knowledge;Longevity;Longitudinal cohort;Messenger RNA;microorganism;Monitor;Nature;neutralizing antibody;novel;novel vaccines;Participant;Patients;Persons;Pfizer-BioNTech COVID-19 vaccine;Population;prognostic;Regimen;research and development;response;RNA vaccination;RNA vaccine;Role;SARS-CoV-2 immune response;SARS-CoV-2 infection;Shapes;Structure of germinal center of lymph node;TNF gene;Vaccinated;Vaccination;Vaccine Design;vaccine development;vaccine efficacy;vaccine platform;vaccine strategy;Vaccinee;Virus;volunteer

PROJECT_TITLE: COVID-19 vaccine in naive individuals and cancer patients


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Cancer;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Lung;Lung Cancer;Nanotechnology;Prevention;Vaccine Related

PI_NAMEs: BERZOFSKY, JAY A (contact)

PROJECT_TERMS: 2019-nCoV;ACE2;Adjuvant;Affect;Air Movements;airway epithelium;aluminum sulfate;Animal Model;Animals;Antibodies;Antibody Specificity;Antibody titer measurement;Antigens;Appearance;Binding;Body Weight decreased;booster vaccine;Bronchoalveolar Lavage Fluid;Cancer cell line;CD8-Positive T-Lymphocytes;Cell Line;Cells;chemokine;Cholesterol;comparison control;Coupled;COVID-19;COVID-19 prevention;COVID-19 susceptibility;COVID-19 vaccine;Data;Dendritic Cells;Diet;dimer;Disease;disorder control;disorder prevention;DNA Vaccines;Dose;Electroporation;Epithelial Cells;experience;Female;Formulation;Gender;gender difference;Granulocyte-Macrophage Colony-Stimulating Factor;Hamsters;health goals;HIV vaccine;Human;Human Cell Line;Immune;Immune response;Immunity;Immunize;immunogenicity;Immunoglobulin A;Immunoglobulin G;immunopathology;improved;In Vitro;in vivo;indicated prevention;Industrialization;Infection;Infection prevention;Interferon Type I;Interleukin-12;Interleukin-15;Licensing;Ligands;Lung;lung cancer cell;Macaca;Macaca mulatta;male;Malignant neoplasm of lung;Medical center;Messenger RNA;Methods;Modeling;Monitor;Morbidity - disease rate;Mouse Strains;Mucosal Immunity;mucosal vaccine;Mucous Membrane;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;nanoparticle;Nasal cavity;Natural Immunity;neutralizing antibody;Non-Small-Cell Lung Carcinoma;nonhuman primate;Nose;Obesity;Omega-3 Fatty Acids;Oropharyngeal;Persons;preclinical study;prevent;Production;Proteins;Public Health;Publishing;Reagent;receptor;receptor binding;Recombinants;respiratory challenge;Respiratory Mucosa;response;Risk Reduction;RNA vaccine;Role;Route;SARS-CoV-2 B.1.1.529;SARS-CoV-2 B.1.617.2;SARS-CoV-2 infection;SARS-CoV-2 spike protein;SARS-CoV-2 variant;Serum;Sex Bias;Site;SIV Vaccines;South African;T cell response;T-Lymphocyte;Testing;Texas;Time;TLR3 gene;TMPRSS2 gene;Touch sensation;transmission process;Universities;Vaccinated;Vaccination;vaccine candidate;vaccine trial;Vaccines;Variant;variants of concern;Vascular Endothelial Cell;Viral;viral transmission;Viral Vaccines;Virion;Virus;Work

PROJECT_TITLE: Studies of the SARS-CoV-2 Spike Protein


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;HIV/AIDS;Human Genome;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: JONES, JENNIFER  (contact)

PROJECT_TERMS: 2019-nCoV;CCR;Clinical;Collaborations;COVID-19;COVID-19 pandemic;COVID-19 treatment;Cryoelectron Microscopy;Detection;Disease;exosome;extracellular vesicles;HIV;human disease;Human Herpesvirus 4;Human Papillomavirus;Laboratories;Methodology;Methods;Molecular Analysis;Monitor;Mouse Mammary Tumor Virus;Mus;nanobiologic;nanobiology;particle;Publishing;Repetitive Sequence;Research;Resources;SARS-CoV-2 infection;Satellite Viruses;Technology;tool;transcriptome sequencing;tumor;Viral;Virus;Virus Diseases;Work

PROJECT_TITLE: Translational Nanobiology Approaches to Viral Diseases (HIV, HTLV, SARS-CoV2)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Cancer;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Lung;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

PI_NAMEs: TARASOVA, NADYA  (contact)

PROJECT_TERMS: Binding;biophysical techniques;Cells;Chemical Structure;Chemicals;Coronavirus Infections;COVID-19;COVID-19 therapeutics;COVID-19 treatment;Data;Databases;Development;Docking;Drug Screening;Eligibility Determination;Escherichia coli;Esters;Evaluation;Generations;Goals;Half-Life;high throughput screening;Human;improved;in silico;in vitro testing;Inflammatory;inhibitor;Lead;Libraries;Long COVID;Mediating;Methods;Mus;N-terminal;novel;Pharmacotherapy;physical state;Plasma;preclinical development;preclinical study;Property;protein structure;Proteins;Recombinants;screening;small molecule;STAT3 gene;Structure;Viral;Viral Proteins;virtual library;Virus

PROJECT_TITLE: Development of COVID-19 cell entry inhibitors


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cancer;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Lung

PI_NAMEs: YARCHOAN, ROBERT  (contact)

PROJECT_TERMS: 2019-nCoV;Active Sites;Acute Respiratory Distress Syndrome;Affect;Anti-viral Agents;Anti-viral Therapy;antiviral drug development;Binding;Biochemistry;CCR;cell killing;Cells;Cessation of life;Chiroptera;Coagulation Process;Collaborations;Coronavirus;Coughing;COVID-19;Cysteine;dimer;Dimerization;Disease Outbreaks;Exposure to;Fever;inhibitor;interest;Middle East Respiratory Syndrome Coronavirus;migration;Multiple Organ Failure;Nonstructural Protein;oxidation;Oxidative Stress;pandemic disease;Papain;Peptide Hydrolases;Physiological;Polyproteins;Predisposition;Prodrugs;Protease Inhibitor;Proteins;RNA Viruses;SARS coronavirus;SARS-CoV-2 inhibitor;SARS-CoV-2 protease;Severe Acute Respiratory Syndrome;Stress;Stroke;Structure;Toxic effect;Viral;Virus

PROJECT_TITLE: Study of and development of antiviral drugs against SARS-CoV2 protease


NIH_SPENDING_CATS: Cancer;Genetics

PI_NAMEs: POMMIER, YVES  (contact)

PROJECT_TERMS: 2019-nCoV;Antibiotics;Antineoplastic Agents;atomic interactions;Bacteria;Binding;Biochemical;Biological Assay;Biological Process;C-terminal;Camptothecin;cancer predisposition;Catalytic Domain;CCR;Cell Line;Cell Nucleus;Cells;Chemicals;Clinical;Clone Cells;cofactor;Complex;CRISPR/Cas technology;Cryoelectron Microscopy;Cytoplasm;Cytoprotection;Defect;DNA;DNA Topoisomerase IV;Dominant-Negative Mutation;Drug Targeting;engineered beta cell;Engineering;Enzymes;experimental study;Family;Genetic Transcription;Genome Stability;Genomics;Growth;helicase;high throughput screening;Homeostasis;Human;Human Cell Line;Hybrids;Immune;Inflammatory;inhibitor;Integration Host Factors;Knock-in Mouse;Knock-out;Knockout Mice;Laboratories;Legal patent;Lethal Genes;Libraries;Lymphoid Cell;Mass Spectrum Analysis;Medicine;Metabolic;Metals;Minor;Modeling;Molecular Target;mutant;National Center for Advancing Translational Sciences;Natural Products;novel;Nucleic Acid Cleavage;Oligonucleotides;Pathway interactions;Pharmaceutical Preparations;Phenotype;Poisoning;Publishing;Reaction;Recombinants;Reporter;Reporting;Resolution;RNA;RNA Folding;RNA Splicing;RNA Viruses;Role;Running;Severe Acute Respiratory Syndrome;Single-Stranded DNA;Splenomegaly;Sterility;structural determinants;Structure;System;Testing;TOP1 gene;TOP2A gene;Topoisomerase;Topoisomerase II;Topoisomerase III;Topoisomerase-I Inhibitor;Transfection;Translations;tumor;United States National Academy of Sciences;Viral Physiology;Western Blotting;Yeasts

PROJECT_TITLE: TOP3B as host factor and drug target


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cancer;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Vaccine Related

PI_NAMEs: CARRINGTON, MARY N. (contact)

PROJECT_TERMS: Antibodies;Autoimmunity;B-Lymphocytes;Biological;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;cohort;Collaborations;COVID-19;cytotoxicity;Data;Disease Outcome;Exhibits;Genes;Genetic;genetic association;genetic resistance;genetic variant;Genotype;Immune;Immune response;Immune Response Genes;Individual;Long COVID;Molecular;monocyte;neutralizing antibody;pathogen;Reporting;Research Personnel;response;Role;SARS-CoV-2 infection;SARS-CoV-2 variant;systemic inflammatory response;Testing;Vaccination

PROJECT_TITLE: Host genetic resistance to COVID-19


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cancer;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Prevention;Vaccine Related

PI_NAMEs: KREITMAN, ROBERT  (contact)

PROJECT_TERMS: 2019-nCoV;Acute;anti-CD20;Antibodies;Antibody Response;antibody test;Antigens;B-Lymphocytes;CD4 Lymphocyte Count;CD4 Positive T Lymphocytes;Cell Count;chemotherapy;Clone Cells;cohort;Collaborations;COVID-19;COVID-19 pandemic;COVID-19 patient;COVID-19 survivors;COVID-19 test;COVID-19 vaccination;COVID-19 vaccine;Disease;Dose;experience;Future;Genes;Hairy Cell Leukemia;Half-Life;Heavy-Chain Immunoglobulins;Hematologic Neoplasms;Immune response;Immune system;Immunoglobulin G;Immunoglobulins;Individual;Infection;Learning;Lymphoma;Malignant Neoplasms;Maryland;Monoclonal Antibody CD20;Mutate;Mutation;Nucleocapsid;Outcome;Patients;Pattern;Peripheral;Persons;Population;Prognosis;Publications;Publishing;Recovery;response;Risk;rituximab;SARS-CoV-2 antibody;SARS-CoV-2 infection;SARS-CoV-2 positive;Symptoms;T-Lymphocyte;Testing;Time;Universities;Vaccination;Vaccines;Variant;Virus Diseases

PROJECT_TITLE: Patterns of immune response in COVID-19 patients


NIH_SPENDING_CATS: Biotechnology;Cancer;Emerging Infectious Diseases;Genetics;HIV/AIDS;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

PI_NAMEs: KRUG, LAURIE T (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Animal Model;Animals;antiretroviral therapy;Area;B cell differentiation;B cell repertoire;B-Cell Lymphomas;B-Lymphocytes;Basic Science;Binding;Biochemical;Biological;Biopsy;Callithrix jacchus jacchus;Cancer Burden;Cause of Death;Cell Culture System;Cell Culture Techniques;Cell Proliferation;cell transformation;Cells;Clinical;Clinical Trials;Clonality;cohort;Collaborations;Complex;cytokine;Development;Disease;DNA Repair;DNA Replication Factor;Endothelial Cells;Enzymes;Epstein-Barr pathogenesis;Etiology;Event;gammaherpesvirus;Gene Expression;Gene Expression Profile;Genes;Genetic;Herpesviridae;Herpesviridae Infections;HIV;HIV/AIDS;Host Defense;Human;Human Herpesvirus 4;Human Herpesvirus 8;immunodeficiency;Implant;Individual;infected B cell;Infection;Interferons;Interphase Cell;Intervention;Investigation;Journals;Kaposi Sarcoma;Knock-out;Knowledge;Laboratories;Laboratory Animal Science;Learning;lymph nodes;Lytic;Malignant - descriptor;Malignant Neoplasms;Molecular;Morbidity - disease rate;mortality;mouse model;Multicentric Angiofollicular Lymphoid Hyperplasia;Mus;nucleotide metabolism;Nucleotides;Oncogenic;participant enrollment;pathogen;Pathogenesis;Pathogenicity;patient derived xenograft model;Patients;Persons;Pharmaceutical Preparations;Population;pre-clinical;pre-clinical research;primary effusion lymphoma;Process;programs;Proliferating;Property;Publishing;rational design;Research;Research Personnel;response;Risk;Role;Sampling;Series;Signal Transduction;skin xenograft;Source;STAT1 gene;STAT3 gene;System;T-Lymphocyte;Therapeutic;Trans-Activators;transcriptome sequencing;Transgenic Mice;tumor;tumor growth;United States National Institutes of Health;uracil-DNA glycosylase;Viral;viral DNA;Virus;virus host interaction

PROJECT_TITLE: Investigation of viral and host determinants of gammaherpesvirus pathogenesis


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Genetics;HIV/AIDS;Hematology;Human Genome;Infectious Diseases;Lymphatic Research;Lymphoma;Orphan Drug;Precision Medicine;Rare Diseases

PI_NAMEs: RAMASWAMI, RAMYA  (contact)

PROJECT_TERMS: Biological Assay;Blood;cancer diagnosis;cancer therapy;Cellular Assay;chemotherapy;Circulation;Clinical Data;Clinical Trials;Collaborations;Correlative Study;cytokine;Development;Disease;Evaluation;genomic platform;genomic profiles;Genomics;HIV;Human Herpesvirus 8;Inflammation;Inflammatory;Interleukin-12;Kaposi Sarcoma;Malignant Neoplasms;Modernization;Morbidity - disease rate;mortality;Multicentric Angiofollicular Lymphoid Hyperplasia;Natural History;Oncology;Pathogenicity;Pathway interactions;patient population;Patients;Persons;primary effusion lymphoma;prospective;Protocols documentation;Publishing;Role;Sampling;T-Lymphocyte;targeted treatment;Technology;Tissues;transcriptome sequencing;Tumor Subtype;United States

PROJECT_TITLE: Targeted therapies for Kaposi sarcoma and KSHV-multicentric Castleman disease


NIH_SPENDING_CATS: Cancer;Natural Products

PI_NAMEs: YOO, EUNA  (contact)

PROJECT_TERMS: Binding;Cells;Chemicals;chemoproteomics;Coupled;covalent bond;Cysteine;Development;Elements;GSTP1 gene;Immune;immune function;immune modulating agents;improved;interest;Investigation;Libraries;Ligands;Modification;Natural Products;novel;pharmacokinetics and pharmacodynamics;Phenotype;Proliferating;protein function;Proteins;Proteome;screening;Site;small molecule;Specificity;T-Cell Activation;Therapeutic;tool

PROJECT_TITLE: Synthesis and characterization of covalent ligands


NIH_SPENDING_CATS: Cancer;Immunotherapy

PROJECT_TERMS: Animal Model;Biology;cancer type;Cell Death;Cell Surface Receptors;Cells;cross reactivity;cytokine;Cytoplasm;Cytotoxic T-Lymphocytes;Event;extracellular;Extracellular Matrix;Fluorescence Resonance Energy Transfer;Granzyme;Image;Imaging Device;imaging probe;Immune;Immune Evasion;Immune system;immunoregulation;Immunotherapy;in vivo;Inflammatory;inhibitor;interest;Kinetics;Measures;Mediating;Monitor;Natural Killer Cells;perforin;Play;protein aminoacid sequence;Regulation;Reporting;response;Role;Series;Serine Protease;T-Lymphocyte and Natural Killer Cell;tool;tumor;tumor microenvironment;tumor progression;VDAC1 gene

PROJECT_TITLE: Understanding functional roles and regulation of granzymes


NIH_SPENDING_CATS: Biotechnology;Cancer

PROJECT_TERMS: activity-based protein profiling;Anti-viral Response;Binding;Biological Assay;Biotin;Cell Line;chemical synthesis;Chemicals;Collaborations;combinatorial;Cysteine;divinyl sulfone;Enzymes;Family;functional group;Genes;high throughput screening;Immunologics;in silico;in vivo;inhibitor;Innate Immune System;Interferon Type I;Interferons;Lung Adenocarcinoma;member;Modeling;mutant;Mutate;National Center for Advancing Translational Sciences;Pathway interactions;Peptide Hydrolases;Peptide Library;Play;Preparation;Proteins;Publications;Reporter;Research;Role;Scanning;Series;Signal Transduction;small molecule;tool;tumorigenesis;Ubiquitin;ubiquitin isopeptidase;ubiquitin-protein ligase;ubiquitin-specific protease;Ubiquitination;Work

PROJECT_TITLE: Targeting ISG15 and USP18


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

PI_NAMEs: TAKEDA, DAVID  (contact)

PROJECT_TERMS: 3-Dimensional;advanced prostate cancer;Affect;Androgen Receptor;Architecture;Automobile Driving;Binding;Biological Models;Cell Survival;Chromatin;chromatin immunoprecipitation;Cues;Disease Progression;Disease Resistance;effective therapy;Enhancers;Epigenetic Process;functional genomics;Gene Expression;Generations;Genetic Screening;Genetic Transcription;Genome;genome-wide;Genomic approach;histone modification;inhibitor;insight;Malignant neoplasm of prostate;Malignant Neoplasms;Normal Cell;novel;Pathogenesis;patient derived xenograft model;Play;programs;promoter;Prostate;prostate cancer cell;Protein-Arginine N-Methyltransferase;Receptor Signaling;Regulatory Element;response;Role;Signal Transduction;spatiotemporal;Therapeutic;therapeutic target;therapy resistant;transcription factor;tumor;tumorigenesis;tumorigenic

PROJECT_TITLE: Mechanism of epigenetic activation during disease progression


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cancer;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases

PI_NAMEs: SCHNEEKLOTH, JOHN  (contact)

PROJECT_TERMS: 2019-nCoV;Anti-viral Agents;betacoronavirus;Binding;Cell model;Clinical Trials;Coronavirus;COVID-19 outbreak;Drug Design;Economics;Elements;Laboratories;mortality;Pharmaceutical Preparations;remdesivir;Reporting;SARS-CoV-2 genome;screening;small molecule;Structure;Therapeutic;Untranslated RNA;viral genomics;Work

PROJECT_TITLE: Targeting Functional RNA Elements in the SARS-CoV-2 Genome


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

PROJECT_TERMS: Advanced Development;advanced disease;advanced prostate cancer;Androgen Receptor;Anti-androgen Therapy;Biopsy;Cells;ChIP-seq;Chromatin;chromatin immunoprecipitation;Clinical;Disease;Disease Progression;Enhancers;Epigenetic Process;epigenetic profiling;epigenomic profiling;Genomics;Goals;Histones;insight;Malignant neoplasm of prostate;Metastatic Neoplasm to the Bone;Methods;Neoadjuvant Therapy;novel;Patients;Plasma;Post-Translational Protein Processing;Prostatic Neoplasms;Radical Prostatectomy;Recurrence;Resistance;resistance mechanism;Role;Sampling;Site;Testing;therapeutic target;therapy resistant;Tissues;transcriptomics;tumor

PROJECT_TITLE: Identification of epigenetic drivers of advanced prostate cancer


NIH_SPENDING_CATS: Cancer;Clinical Research

PI_NAMEs: MAYER, CHRISTIAN  (contact)

PROJECT_TERMS: adaptive immune response;adaptive immunity;Affinity;Alleles;Antibody Affinity;Antibody Response;antigen binding;Antigen Receptors;Apoptosis;autoinflammation;autoreactive B cell;autoreactivity;B cell differentiation;B-Cell Antigen Receptor;B-Cell Development;B-Lymphocytes;Bone Marrow;CASP3 gene;Cell Death;Cell Maturation;Cell Survival;Cells;Cellular biology;Clonal Deletion;Cues;Dangerousness;Defect;Dendritic Cells;Development;Event;Fibroblasts;Genes;Goals;human disease;humoral immunity deficiency;Immunoglobulin A;Immunologist;immunoregulation;Inflammatory;Informal Social Control;inhibitor;Link;Mediating;Memory B-Lymphocyte;Methods;Monoclonal Antibodies;mucosal site;Mutation;NF-kappa B;Patients;Peripheral;peripheral tolerance;Phenotype;Physiological;Plasma Cells;Predisposition;Process;Production;Proliferating;Proteins;Reaction;Regulation;response;Self Tolerance;Signal Transduction;Structure of germinal center of lymph node;T-Lymphocyte;Testing;TNF gene

PROJECT_TITLE: Regulation of self-tolerance and adaptive immunity by cell death and other cues


NIH_SPENDING_CATS: Arthritis;Cancer;Digestive Diseases;Immunotherapy;Infectious Diseases;Pancreatic Cancer;Rare Diseases

PI_NAMEs: ASHWELL, JONATHAN  (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;Ankylosing spondylitis;Anti-CD40;Anti-Tumor Necrosis Factor Therapy;Antibodies;Antigen Presentation;Apoptotic;Autoimmune;B-Lymphocytes;Bone Marrow;Cell Count;Cell Physiology;Cell Surface Receptors;Cells;Couples;cytokine;Death Domain;Dendritic Cells;Disease;FDA approved;FLT3 ligand;Generations;Genetically Engineered Mouse;Growth;Human;human disease;Immune system;Immunosuppression;In Vitro;in vivo Model;Induction of Apoptosis;Infiltration;Inflammation;Inflammatory;Knockout Mice;KPC model;KRAS2 gene;Laboratory Finding;Macrophage;Malignant Neoplasms;Mediating;mortality;Mus;Neoplasm Transplantation;Oncogenic;Pancreatic Adenocarcinoma;Pathway interactions;programmed cell death ligand 1;Psoriasis;receptor;Receptors, Tumor Necrosis Factor, Type II;Rheumatoid Arthritis;Signal Transduction;Source;T-Cell Activation;T-Lymphocyte;therapeutic target;TNF gene;TNFRSF1A gene;TNFRSF1B gene;transcriptomics;tumor;Tumor Necrosis Factor Receptor;tumor progression;Tumor-infiltrating immune cells;tumorigenic;Virus Diseases;Work

PROJECT_TITLE: TNF and inflammation


PI_NAMEs: VALKOV, EUGENE  (contact)

PROJECT_TERMS: Address;Affect;Affinity;age-related disease;Architecture;Autoimmune Diseases;Biochemical;Biological Assay;C-terminal;Catalytic Domain;Cell Line;Cells;Complex;Cryoelectron Microscopy;Crystallization;Cytoplasm;Disease;Docking;Enhancers;Enzymes;Excision;Exonuclease;Fission Yeast;Gene Expression;Gene Expression Regulation;genome editing;Goals;Human;improved;In Vitro;Individual;Infrastructure;insight;Investigation;Kinetics;Knock-out;Laboratories;Length;Malignant Neoplasms;Mammals;Mediating;Messenger RNA;Methodology;milligram;Modeling;Modification;Molecular;Molecular Conformation;Mutagenesis;Nerve Degeneration;Nucleotides;Oncogenic;Pathway interactions;Peptides;Phase;Physical condensation;Play;Poly(A) Tail;polyadenosine;Positioning Attribute;Post-Transcriptional Regulation;Process;Production;protein complex;Protein Complex Subunit;Protein Dynamics;protein protein interaction;protein purification;Proteins;Reaction;Recombinants;reconstitution;recruit;Regulation;Repression;Resolution;RNA;RNA Binding;RNA Decay;RNA Degradation;RNA purification;RNA-Binding Proteins;Role;Rotation;Site;Specificity;Structure;System;Tail;Testing;transcriptome;Translational Repression;Translations;Work;Yeasts

PROJECT_TITLE: Molecular Mechanisms of mRNA Regulation and Decay


PI_NAMEs: HANNENHALLI, SRIDHAR  (contact)

PROJECT_TERMS: Alternative Splicing;biological adaptation to stress;BRAF gene;cancer therapy;cancer type;Cells;Cellular Stress;cohort;Collaborations;colonization resistance;comparative;Data;Data Set;Development;Embryo;embryo cell;Embryonic and Fetal Development;Evolution;Exclusion;Exhibits;experimental study;Gene Cluster;Gene Expression Profile;Genes;Genetic Transcription;Global Change;Human;Hybrids;Immune;immune checkpoint blockade;immune resistance;Immune System Diseases;Immunosuppression;Link;Malignant Neoplasms;Manuscripts;Maps;Mediating;melanoblast;melanocyte;Melanoma;Melanoma Cell;Mesenchymal;Metastatic Melanoma;Modeling;Molecular;Morphology;mouse model;Mus;Mutation;Natural regeneration;Neoplasm Metastasis;neoplastic cell;novel;Patients;Pattern;Pharmaceutical Preparations;Population;Predisposition;Process;Processed Genes;programs;Proliferating;Proteins;Publishing;Reporting;Resistance;Resolution;response;RNA Splicing;Role;Schools;Schwann Cells;single-cell RNA sequencing;stem;targeted treatment;therapy resistant;Time;tool;transcription factor;treatment response;tumor;tumorigenesis;Variant;Work;wound healing

PROJECT_TITLE: Developmental and Homeostatic origins of cancer


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Precision Medicine;Rare Diseases

PROJECT_TERMS: Affect;astrocyte progenitor;Bioconductor;Biological Markers;Biological Process;biological systems;Brain;Cancer Biology;cancer cell;cancer type;Cell Communication;Cell Physiology;Cell surface;cell type;Cells;Clinical;Clinical Trials;clinically relevant;computational pipelines;Data;Data Set;DNA Damage;Embryonic Development;gene function;Genes;Genetic;genetic signature;Genetic Transcription;Glioma;Human;Immune;intercellular communication;Malignant Neoplasms;malignant state;Manuscripts;Mediating;mutant;Myeloid Cells;neoplasm immunotherapy;Neurons;novel strategies;oligodendrocyte progenitor;Oncogenic;Outcome;patient stratification;Phenotype;Process;prognostic of survival;Proliferating;Proteins;Reporting;repository;responders and non-responders;response;stem cells;stemness;Therapeutic Intervention;Tissues;tool;transcriptomics;tumor;tumor microenvironment;tumor progression;Work;Writing

PROJECT_TITLE: Context-specific functions of genes and cells


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: SAHINALP, SULEYMAN  (contact)

PROJECT_TERMS: Algorithmic Software;Algorithms;Biopsy;Cell model;Cells;Combinatorial Optimization;computerized tools;Data;deep neural network;Evolution;exome;Genome;Goals;Growth;Heterogeneity;liquid biopsy;Malignant Neoplasms;mathematical algorithm;mathematical methods;Melanoma;methylome;Modeling;Mus;Mutation;neoplastic cell;novel;single cell sequencing;Techniques;Time;transcriptome;transcriptome sequencing;Trees;tumor;tumor heterogeneity;Work

PROJECT_TITLE: Tumor evolution and intratumor heterogeneity


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: clinical trial recruitment;Computer software;Computer Systems;Data Analyses;Environment;Genome;genome analysis;genome wide association study;genomic data;Genomics;Goals;improved;interest;Machine Learning;Memory;Microprocessor;Modernization;Phase;privacy preservation;Secure;Techniques;Trust

PROJECT_TITLE: Privacy Preserving Genome Analysis


PI_NAMEs: ROPER, NITIN  (contact)

PROJECT_TERMS: Biological;Cell Differentiation process;Cells;checkpoint inhibition;Epigenetic Process;Goals;Immunologics;Immunotherapy;interest;neuroendocrine cancer;Neuroendocrine Tumors;notch protein;predicting response;Research;response;Signal Transduction;small cell lung carcinoma;treatment response;Tumor Immunity;Work

PROJECT_TITLE: Epigenetic and immunologic aspects of neuroendocrine cancers


NIH_SPENDING_CATS: Cancer;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases

PI_NAMEs: YOUKHARIBACHE, PHILIPPE  (contact)

PROJECT_TERMS: 2019-nCoV;ACE2;Amino Acid Transporter;Amino Acids;Animals;anti-cancer;Anti-viral Agents;Arginine;betacoronavirus;Binding;Biological Markers;Bovine leukemia;Bovine Leukemia Virus;CCL21 gene;Cell Differentiation process;Cell surface;Cell Surface Proteins;Cell Surface Receptors;Cells;Cellular Metabolic Process;Collaborations;Complex;computational pipelines;Computer software;Coronavirus;Data;data-driven model;design;Development;Diagnosis;Endogenous Retroviruses;Epitopes;Exhibits;Family;Feline Leukemia Virus;France;G-Protein-Coupled Receptors;Glucose;Glucose Transporter;Glutamine;Glycoproteins;Goals;Homologous Gene;Human;Human Genome;Human T-Cell Leukemia Viruses;Immune response;improved;In Vitro;in vivo;Inflammation;innovation;invention;Legal patent;Ligands;Measures;member;Membrane Proteins;Methodology;Methods;model building;Molecular;Mus;Neutral Amino Acid Transport Systems;Normal Cell;Nutrient;Oncogenic;Papio;Paris, France;Play;polypeptide;Primates;Process;Proteins;receptor;receptor binding;Receptor Cell;Research;Retroviridae;Role;Serine;SLC2A1 gene;software development;Specificity;Structure;Supersecondary Protein Structure;syncytin;System;TMPRSS2 gene;tool;tumorigenesis;Virus Diseases;virus envelope;Virus Receptors

PROJECT_TITLE: Structural basis of viral RBDs binding to cell receptors


NIH_SPENDING_CATS: Cancer;Genetics;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: YOHE, MARIELLE  (contact)

PROJECT_TERMS: anti-cancer research;Cells;Childhood Soft Tissue Sarcoma;Collaborations;Combined Modality Therapy;Defect;Diagnosis;Differentiation Therapy;Exclusion;Failure;Genes;Genetic Transcription;Goals;GTPase-Activating Proteins;Homologous Gene;Invaded;knock-down;Molecular;Myoblasts;Neoplasm Metastasis;novel therapeutics;Nuclear;Paper;Pathway interactions;Phosphorylation;prevent;Prognosis;Publications;Publishing;Recurrence;Recurrent tumor;Regulation;Rhabdomyosarcoma;Role;Signal Transduction;Skeletal Muscle;therapeutic target;Transcription Coactivator;transcription factor;Tumor Cell Invasion;tumor growth;Tumor Suppressor Proteins;Work;Xenograft Model

PROJECT_TITLE: Regulation of differentiation and invasion in RMS by ASAP1


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Hematology;Human Genome;Immunotherapy;Orphan Drug;Pediatric;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PI_NAMEs: HICKSTEIN, DENNIS  (contact)

PROJECT_TERMS: Age;alemtuzumab;Alkylating Agents;Allogenic;Busulfan;Chimerism;Clinical;cohort;conditioning;congenital immunodeficiency;curative treatments;Cyclophosphamide;Defect;Disease;disease phenotype;Donor Selection;donor stem cell;Dose;efficacy evaluation;Engraftment;exome sequencing;fludarabine;gain of function mutation;genome sequencing;Hematological Disease;Hematopoiesis;Hematopoietic Stem Cell Transplantation;hematopoietic transplantation;HLA-A gene;Immune;immune function;immunodeficiency;Infection;Life;loss of function;Marrow;mycophenolate mofetil;Myeloid Cells;neutrophil;Organism;Participant;Patients;post-transplant;programs;Prophylactic treatment;reconstitution;Recording of previous events;Recovery;Regimen;Resolution;response;Safety;Source;T-Lymphocyte;Tacrolimus;Transplantation Conditioning;whole genome;Whole-Body Irradiation

PROJECT_TITLE: Allogeneic Hematopoietic Transplantation for Primary Immunodeficiency Diseases


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Orphan Drug;Patient Safety;Rare Diseases

PI_NAMEs: FIGG, WILLIAM DOUGLAS (contact)

PROJECT_TERMS: Affect;AIDS related cancer;Animal Disease Models;Anti-HIV Agents;Antibodies;Anticoagulants;BAY 54-9085;Blood;Blood coagulation;bone;CDK4 gene;Cell Cycle;Clinical;Clinical Pharmacology;comorbidity;Cyclin D1;cyclin D3;Cyclin-Dependent Kinase Inhibitor;Cyclins;CYP3A4 gene;Cytotoxic Chemotherapy;Disease remission;Dose;Drug Exposure;Drug Interactions;Drug Kinetics;Endothelial Cells;Endothelium;Gastrointestinal tract structure;Goals;Health;healthy volunteer;Hemorrhage;HIV;HIV diagnosis;HIV Seronegativity;HIV therapy;Human;Human Herpesvirus 8;improved;interest;Interleukin 6 Receptor;Kaposi Sarcoma;Laboratories;Liposomal Doxorubicin;Lung;Lymph Node Involvement;Malignant Neoplasms;Metastatic breast cancer;meter;Modeling;Morbidity - disease rate;Multicentric Angiofollicular Lymphoid Hyperplasia;Oral;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Phase;Phosphorylation;Phosphotransferases;pomalidomide;prevent;Proliferating;Proteins;Recurrence;Refractory;Relapse;Retinoblastoma;Retinoblastoma Protein;rifapentine;Ritonavir;Safety;Signal Pathway;Skin;Tenofovir;Therapeutic;Therapeutic Agents;therapeutic target;tocilizumab;Treatment Protocols;tuberculosis treatment;tumor;Umbilical vein;Work

PROJECT_TITLE: Clinical Pharmacology and Drug-Drug Interactions in HIV-Associated Malignancy


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Data Science;Gene Therapy;Genetics;Immunotherapy;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Antibodies;antigen binding;Antigen Targeting;Architecture;Big Data;Binding;Bioinformatics;Biological;biophysical properties;biophysical techniques;Biophysics;CAR T cell therapy;CD19 gene;CD22 gene;CD28 gene;CD8B1 gene;Cell surface;Cell Surface Receptors;Chimera organism;chimeric antigen receptor;Clinical Trials;Collaborations;combinatorial;Complex;Computational Technique;Computer software;computerized tools;Data;data repository;Data Science;design;Dimerization;Disease;electron tomography;Elements;Engineering;Environment;extracellular;Extracellular Domain;FDA approved;flexibility;Goals;Immunoglobulin Domain;Immunotherapeutic agent;improved;in silico;In Vitro;in vivo;interest;Knowledge;Machine Learning;Mediating;Membrane;Methods;Microtomy;Mining;Modeling;Molecular;monomer;nanobodies;novel strategies;Process;Property;protein structure;Proteins;rational design;Reporting;Role;simulation;Specificity;Structure;Structure-Activity Relationship;Synapses;synaptogenesis;System;Techniques;tool;Toxic effect;X-Ray Crystallography

PROJECT_TITLE: CAR and Antibodies Structure-Activity Relationships and molecular architecture


PI_NAMEs: YOUNG, RYAN  (contact)

PROJECT_TERMS: Anemia;ARID1A gene;B-Lymphocytes;Biochemical;Biology;Blood;bone loss;Bone Marrow;Calcium;cancer diagnosis;cell growth;Cell Line;Cell Survival;Cells;Cellular biology;Cessation of life;Chromatin Remodeling Factor;Clinical;cofactor;Collaborations;conditional knockout;CRISPR screen;debilitating symptom;Dedications;design;Development;Disease;effective therapy;Essential Genes;experience;experimental study;Fracture;Future;Genes;Genetic Heterogeneity;Genetic Transcription;Goals;Growth;high risk;Human;Image;Immunity;improved;In Vitro;in vivo;inhibitor;IRF4 gene;Knock-in;Label;loss of function mutation;Malignant - descriptor;Malignant Neoplasms;Methods;Multiple Myeloma;Mus;Mutation;novel;novel therapeutics;Oncogenic;Pathway interactions;Patients;Pharmaceutical Preparations;plasma cell development;Plasma Cells;Pre-Clinical Model;Proteins;proteogenomics;Refractory;Relapse;Reporter;Research;Resistance;Resistance development;risk minimization;Role;Signal Transduction;SMARCA2 gene;SWI/SNF Family Complex;Symptoms;Therapeutic;therapeutic target;therapy resistant;tool;Translating;tumor;Tumor Suppressor Proteins;Variant

PROJECT_TITLE: Identifying novel modes of oncogenic signaling in multiple myeloma


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Rare Diseases

PI_NAMEs: RAJAN, ARUN  (contact)

PROJECT_TERMS: Adverse event;Aftercare;Cells;cohort;Disease;Enrollment;Epithelium;Evaluation;Immune;objective response rate;partial response;participant enrollment;Patients;phase II trial;programmed cell death ligand 1;Progression-Free Survivals;Recurrence;Refractory;Relapse;response;Safety;Thymic Carcinoma;Thymoma;Thymus Gland

PROJECT_TITLE: Phase II Trial of Bintrafusp Alfa in Subjects with Thymoma and Thymic Carcinoma


NIH_SPENDING_CATS: Cancer;Genetics

PI_NAMEs: MURGAI, MEERA  (contact)

PROJECT_TERMS: Address;Behavior;blood vessel development;Blood Vessels;cell growth;Cell Survival;cell type;Cells;Cessation of life;CSPG4 gene;Data;Distant;Epigenetic Process;Extracellular Matrix;Genetic;Goals;Growth;Hematopoietic;improved;Malignant Neoplasms;Mediating;Modeling;Molecular;Neoplasm Metastasis;neoplastic cell;Nodule;novel therapeutics;Organ;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pericytes;Phenotype;pluripotency;Population;Primary Neoplasm;Process;Production;Proliferating;recruit;response;Role;Site;Smooth Muscle Myocytes;Stromal Cells;Therapeutic;therapeutic development;Tissues;transcription factor;tumor;Vascular Smooth Muscle;Work

PROJECT_TITLE: Perivascular plasticity in metastatic microenvironments


PI_NAMEs: ALTAN-BONNET, GREGOIRE  (contact)

PROJECT_TERMS: antagonist;Antigen Presentation;Antigens;betacoronavirus;Cells;Collaborations;Coronavirus;Cross Presentation;Defect;Discrimination;Dose;Experimental Models;Feedback;Goals;Human;IFIH1;Immune;Immune response;Immunology;interest;Intramural Research Program;Kinetics;Life Cycle Stages;Ligands;Modeling;Monitor;National Heart, Lung, and Blood Institute;Natural Killer Cells;Nature;Pathway interactions;Phenotype;Publications;response;RNA;T-Cell Activation;Testing;viral detection;viral RNA;Virus;Virus Diseases

PROJECT_TITLE: Dynamics of viral infection


NIH_SPENDING_CATS: Cancer;Lung;Lung Cancer;Microbiome

PI_NAMEs: ZHAO, CHEN  (contact)

PROJECT_TERMS: aerosolized;Animal Model;Antibiotics;Bacteria;Cells;Clinical Trials;Collaborations;Complex;Enrollment;Goals;Immune;lung microbiota;metatranscriptomics;Methods;Microbe;microbiome;mouse model;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;Pathology;patient prognosis;Patients;pembrolizumab;Pennsylvania;Plants;preservation;Resolution;Sampling;Spatial Distribution;tumor;tumor growth;tumor microenvironment;Tumor Promotion;Universities

PROJECT_TITLE: Study interactions between lung microbiota and immune cells in NSCLC


NIH_SPENDING_CATS: Cancer;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

PI_NAMEs: DAVIES, ERIN  (contact)

PROJECT_TERMS: Adolescent;Adult;adult stem cell;Anatomy;Animal Model;Animals;Anterior;beta catenin;blastema;cell type;Cells;Competence;Cues;Data;Defect;Development;Embryo;Embryonic Development;Failure;Genetic;Genetic Transcription;Genomics;hatching;Head;inhibitor;Injury;irradiation;knock-down;Manuscripts;Natural regeneration;Organogenesis;Pathway interactions;Pattern;Planarians;Platyhelminths;Pluripotent Stem Cells;Positioning Attribute;Printing;Production;Property;regenerative;Regenerative engineering;Reporting;Reverse engineering;RNA Interference;Signal Pathway;Source;stem cells;stem-like cell;Structure;System;Tissues;Work;wound

PROJECT_TITLE: Mechanisms underlying the establishment of whole-body regeneration competence


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Prostate Cancer;Urologic Diseases;Women's Health Research

PI_NAMEs: STRACKER, TRAVIS  (contact)

PROJECT_TERMS: cancer cell;Cancer Model;cancer therapy;cancer type;Candidate Disease Gene;Cell Fate Control;Clinical;CRISPR/Cas technology;Deposition;DNA;DNA Damage;DNA lesion;DNA Sequence Alteration;Genes;Genetic;Genetic Screening;Genomic Instability;Goals;Histones;In Vitro;in vivo;inhibitor;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Methods;Mutation;neoplasm immunotherapy;neoplastic cell;Optics;Pathway interactions;Phosphotransferases;Proliferating;Proteomics;Recurrence;Research;Resistance;response;Role;screening;Series;Signal Pathway;small molecule;small molecule inhibitor;synthetic lethal interaction;targeted cancer therapy;targeted treatment;telomere;Telomere Pathway;Therapeutic Agents;therapy resistant;tumor growth;Work

PROJECT_TITLE: Targeting the DNA damage response in cancer therapy


NIH_SPENDING_CATS: Biotechnology;Cancer;Emerging Infectious Diseases;Genetics;HIV/AIDS;Hematology;Immunization;Immunotherapy;Infectious Diseases;Lymphatic Research;Lymphoma;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

PI_NAMEs: KRUG, LAURIE T (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;adaptive immune response;AIDS related cancer;antiretroviral therapy;B cell repertoire;B-Cell Lymphomas;B-Lymphocytes;Cancer Burden;Cancer Etiology;Cause of Death;Cells;chemotherapy;Clinical;Clinical Trials;Codon Nucleotides;Collaborations;Complex;Cyclin-Dependent Kinases;design;Development;Disease;effective therapy;Enrollment;Flow Cytometry;gammaherpesvirus;gene complementation;gene editing technology;gene product;Genes;Goals;Growth;Herpesviridae;Herpesvirus Vaccines;high risk population;HIV;HIV/AIDS;Human Herpesvirus 4;Human Herpesvirus 8;Immune;immune modulating agents;Immune response;Immunotherapy;improved;Individual;Infection;Infection prevention;Innate Immune Response;Intervention;Journals;Kaposi Sarcoma;Laboratories;Lymphoma;Lymphoproliferative Disorders;lytic gene expression;Malignant neoplasm of nasopharynx;Malignant Neoplasms;malignant stomach neoplasm;Methods;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Mutate;Names;novel;novel vaccines;Oncogenic;pathogen;patient derived xenograft model;patient response;Patients;Peripheral Blood Mononuclear Cell;Persons;pomalidomide;Post-Translational Protein Processing;post-transplant;Pre-Clinical Model;pre-clinical research;primary effusion lymphoma;Process;programs;Publishing;recombinant virus;Research;Resolution;response;Risk;Sampling;small molecule inhibitor;standard care;Sterically Stabilized Liposome;success;T cell response;T-Lymphocyte;Testing;therapeutic genome editing;Therapeutic Intervention;tumor;tumorigenesis;Ubiquitination;Vaccination;vaccine candidate;vaccine formulation;vaccine strategy;Vaccines;Viral Genes;Viral Load result;Virus;Virus Replication

PROJECT_TITLE: Novel interventions for gammaherpesvirus infection and AIDS-Related Malignancies


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: LAZZERINI DENCHI, EROS  (contact)

PROJECT_TERMS: Apoptosis;cancer cell;Cell Cycle Arrest;Cell Proliferation;Cells;Chromosomes;Defect;DNA Damage;functional genomics;Gene Targeting;Genomic approach;Genomic Instability;Goals;Mammalian Cell;Mouse Embryonic Stem Cells;novel;Pathway interactions;Process;Property;Research Project Grants;response;stem cells;telomere

PROJECT_TITLE: Mechanism of end protection in stem cells


NIH_SPENDING_CATS: Cancer;Immunotherapy;Kidney Disease;Orphan Drug;Rare Diseases

PI_NAMEs: MERINO, MARIA  (contact)

PROJECT_TERMS: antigen-specific T cells;Benign;cancer cell;cancer therapy;CD3 Antigens;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;cell type;Cells;cytotoxic;Data;density;Development;Drug Targeting;Evaluation;Flow Cytometry;Frequencies;immune cell infiltrate;Immune response;Immunotherapy;improved;Infiltration;intraepithelial;Kidney Neoplasms;Malignant - descriptor;Malignant neoplasm of lung;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Memory;Molecular;Outcome;Pattern;Population;predicting response;prognostic;Renal Carcinoma;Renal Cell Carcinoma;response;Skin Cancer;Solid Neoplasm;Spatial Distribution;Structure;T-Lymphocyte;Testing;Tissues;tumor;Tumor Antigens;Tumor-infiltrating immune cells;Tumor-Infiltrating Lymphocytes

PROJECT_TITLE: Immunotherapy of kidney cancer. Where do the T lymphocytes go in kidney cancer?


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Hematology;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: PAVLETIC, STEVEN  (contact)

PROJECT_TERMS: Acute Myelocytic Leukemia;Adult;Allogenic;CCR;Child;Childhood Leukemia;Clinic;Clinical;Clinical Research;Clonal Hematopoietic Stem Cell;Collection;comorbidity;curative treatments;cytopenia;Dedications;Development;Diagnosis;Disease;Dysmyelopoietic Syndromes;Dysplasia;Elderly;genotoxicity;Hematopoietic Stem Cell Transplantation;Hereditary Disease;high risk;Immunotherapy;Individual;Ineffective Hematopoiesis;Laboratory Research;leukemia;Malignant - descriptor;Malignant Neoplasms;Marrow;Mission;Mutation;Myeloproliferative disease;Natural History;novel therapeutics;organizational structure;Partial Remission;Pathogenesis;Patients;peripheral blood;Pharmaceutical Chemistry;prevent;programs;Progressive Disease;Proteomics;Research Personnel;RUNX1 gene;Science;Secondary Myelodysplastic Syndrome;Therapeutic;Translating;Translations;United States National Institutes of Health;Vision;young adult

PROJECT_TITLE: NIH Myeloid Malignancy Program


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Cancer;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases

PI_NAMEs: MITSUYA, HIROAKI  (contact)

PROJECT_TERMS: 2019-nCoV;acquired drug resistance;Amino Acid Substitution;Amino Acids;Anti-viral Agents;Anti-viral resistance;benzothiazole;Binding;Biological Assay;Cell Culture Techniques;Cells;Clinical;covalent bond;COVID-19;COVID-19 susceptibility;COVID-19 therapeutics;COVID-19 treatment;Data;design;Development;Dimerization;Drug resistance;drug resistance development;Educational process of instructing;Enzymes;experimental study;FDA Emergency Use Authorization;Fluorine;global health;HIV;Hospitalization;Immunocompromised Host;In Vitro;inhibitor;K-18 conjugate;Literature;Mass Spectrum Analysis;Metabolism;molnupiravir;Mus;Mutation;Nature;nirmatrelvir;novel;Oral;Oral Administration;pandemic disease;Patients;Peptide Hydrolases;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Predisposition;Prophylactic treatment;Protease Inhibitor;Recombinants;remdesivir;Reporting;Resistance;Ritonavir;RNA Polymerase Inhibitor;RNA Viruses;RNA-Directed RNA Polymerase;Roentgen Rays;SARS coronavirus;SARS-CoV-2 B.1.1.529;SARS-CoV-2 infection;SARS-CoV-2 variant;Scanning;severe COVID-19;small molecule;Testing;theories;Therapeutic;therapeutic development;Transcript;Transgenic Mice;treatment duration;Treatment Protocols;Tube;Variant;Viral;viral fitness;Virus;Virus Inhibitors;Virus Receptors

PROJECT_TITLE: Development of therapeutics for SARS-CoV-2 infection


PI_NAMEs: GONATOPOULOS-POURNATZIS, THOMAS  (contact)

PROJECT_TERMS: 3' Splice Site;Address;Alternative Splicing;Automobile Driving;bioinformatics tool;Cell Physiology;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Complex;Dedications;deep sequencing;Disease;endoplasmic reticulum stress;Event;Exons;EZH2 gene;functional genomics;Genes;Genetic;Genome;genome-wide;Goals;Human;innovation;interdisciplinary approach;Introns;Knowledge;Link;Malignant Neoplasms;Maps;Mechanics;Messenger RNA;Molecular;Molecular Analysis;Molecular Biology;Molecular Target;Monitor;mRNA Precursor;Neurodevelopmental Disorder;novel;Outcome;Pathogenesis;Pathway interactions;Phenotype;Process;Progeria;programs;Protein Isoforms;Proteins;Regulation;Regulatory Pathway;Reporter;Research;response;RNA;RNA Splicing;RNA-Binding Proteins;Role;Sampling;Signal Transduction;Syndrome;Techniques;Technology;transcriptome;XBP1 gene

PROJECT_TITLE: Map Novel Regulatory Networks that Control Alternative Splicing