ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE Drug addiction is a disorder of the brain that puts a heavy burden on society. Studies proposed herein are aimed at understanding molecular mechanisms and adaptations in brain circuitry that underlie the rewarding effects of opioid drugs. It is anticipated that the results will facilitate the design of novel strategies for the treatment of drug addiction addressing a critical need to combat growing opioid abuse epidemic.

PI_NAMEs: MARTEMYANOV, KIRILL A. (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Ablation;abuse liability;Address;Affect;Analgesics;Animal Model;Area;Basal Ganglia;Behavior;behavior influence;Behavioral;behavioral response;Biological;Biological Assay;Brain;brain circuitry;Brain Diseases;Brain region;Cell Adhesion Molecules;Cells;cholinergic;Chronic;combat;Communication;Complex;Corpus striatum structure;Data;design;Development;Dimensions;Drug Addiction;drug seeking behavior;Electrophysiology (science);Epidemic;experimental study;extracellular;functional plasticity;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Genetic;glutamatergic signaling;Glutamates;Goals;innovation;insight;Interneurons;Laboratories;Learning;Link;Maps;Mediating;metabotropic glutamate receptor 4;Metabotropic Glutamate Receptors;Molecular;Morphology;Motivation;mouse model;mu opioid receptors;Mus;nerve supply;Nervous System;neural circuit;Neurons;neuroregulation;Neurotransmitters;novel;novel strategies;Nucleus Accumbens;Opiate Addiction;Opioid;opioid abuse;opioid epidemic;opioid use disorder;Optics;overexpression;Pharmaceutical Preparations;Physiological;Play;postsynaptic;presynaptic;Presynaptic Terminals;Process;Property;Reagent;receptor;Research;Resolution;reward processing;Rewards;Role;selective expression;Shapes;signal processing;Signal Transduction;Societies;Specific qualifier value;Specificity;Structure;Synapses;Synaptic plasticity;Synaptic Transmission;System;Techniques;Testing;treatment strategy;Viral

PROJECT_TITLE: Trans-synaptic control of GPCR signaling in opioid reward

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: MILWAUKEE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative Antibiotic-resistant bacteria, such as vancomycin-resistant enterococci (VRE) and methicillin- resistant Staphylococcus aureus (MRSA), are major causes of hospital-acquired infections and contribute to an escalating healthcare crisis. The research proposed here promises to reveal new insights into the biological processes driving antibiotic resistance that will facilitate the development of new treatments for infections caused by drug-resistant pathogens. In particular, this work promises to define new targets for innovative therapeutics with potentially unique modes of action.

PI_NAMEs: KRISTICH, CHRISTOPHER J (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Address;analog;Antibiotic Resistance;Antibiotics;antimicrobial;Antimicrobial Resistance;Automobile Driving;Bacteria;Bacterial Antibiotic Resistance;bacterial resistance;beta-Lactams;Binding;Binding Proteins;Biochemical;Biological Process;cell envelope;Cell Wall;Cephalosporin Resistance;Cephalosporins;Classification;Clinical;clinically relevant;clinically significant;crosslink;Data;design;Development;Disabling;drug resistant pathogen;emerging antibiotic resistance;Enterococcus;Enterococcus faecalis;Enterococcus faecium;enzyme activity;Enzymes;experience;Foundations;Future;Genetic;Genome;Healthcare;Hospitals;Impairment;Infection;innovation;insight;Intervention;Knowledge;Membrane;methicillin resistant Staphylococcus aureus;Modeling;Molecular Target;Multi-Drug Resistance;Nosocomial Infections;novel;novel therapeutics;nucleotide metabolism;Nucleotides;pathogen;Pathway interactions;Penicillin-Binding Proteins;Peptidoglycan;phosphoric diester hydrolase;Physiological;Process;programs;Proteins;Regulation;Reporting;Research;Resistance;response;Role;Safety;Second Messenger Systems;sensory input;Signal Pathway;Signal Transduction;Signaling Molecule;small molecule;Stress;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;United States;Vancomycin resistant enterococcus;Work

PROJECT_TITLE: Role and regulation of intracellular signaling in enterococcal antimicrobial resistance

STUDY_SECTION: AIRT

STUDY_SECTION_NAME: Anti-Infective Resistance and Targets Study Section [AIRT]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Inequities in access to power, resources, and services based on structural racism and discrimination (SRD), can manifest as policies and practices that can cause psychological distress, elevated allostatic load, and elevated risk of chronic diseases for Black and Latinx populations. While the connection between SRD and health is well documented, few studies provide evidence on strategies to reduce SRD and mitigate consequences on psychological and physiological outcomes. This project uses a randomized, behavioral clinical trial to test racial justice activism (RJA) as an effective intervention to mitigate depression and allostatic load in Black and Latinx adolescents and young adults, impacted by SRD.

PI_NAMEs: HEARD-GARRIS, NIA JENEE' (contact);HOPE, ELAN

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: access disparities;Address;Adolescence;Adolescent and Young Adult;aged;allostatic load;anti-racism;Anxiety;arm;Attention;Attenuated;Behavior Therapy;behavioral clinical trial;Black Populations;Black race;Blood;Blood Pressure;C-reactive protein;Cardiovascular Diseases;Categories;Cessation of life;Chicago;Chronic;Chronic Disease;clinically relevant;comparison control;Data;Dependence;depressive symptoms;Diabetes Mellitus;Discrimination;disorder risk;Educational process of instructing;effective intervention;Environment;Equity;Evidence based intervention;experience;Fostering;Gender;Goals;Health;health assessment;health disparity;health equity;Health Promotion;Hydrocortisone;Illinois;Imprisonment;improved;Individual;Interleukin-6;intersectionality;Intervention;intervention participants;Intervention Studies;Interview;Justice;Latinx;Latinx population;Length;Life;Malignant Neoplasms;Measures;Mental Depression;Mental Health;multilevel analysis;Murder;older adult;Outcome;Participant;Pathway interactions;Patients;Peer Group;perceived stress;Persons;physical conditioning;Physiological;Policies;Population;post intervention;premature;prevent;Prevention;psychologic;psychological distress;Questionnaires;Race;Randomized;recruit;Reduce health disparities;Reporting;Research;Research Methodology;Resources;response;Risk;Role;secondary outcome;Services;Sexuality;Shapes;skills;skills training;Social Sciences;Stress;Structural Racism;Structure;Testing;tool;translational approach;treatment arm;virtual;Voice;Work;Youth

PROJECT_TITLE: Our Voices Matter: Racial Justice Activism Intervention to Address Structural Racism and Prevent Depression in Black and Latinx Youth

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: KANSAS CITY

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI KANSAS CITY

ORG_STATE: MO

PHR: Project Narrative The loud operating room (OR) environment is a distinct threat to unobstructed communication between OR team members that compromises patient safety. The current proposal will develop interventions surrounding overlapping conversations and environmental noise using a systems approach to prevent, mitigate, and recover from miscommunication. These interventions will provide an essential foundation for improving OR team communication and enhancing patient safety.

PI_NAMEs: SUTKIN, GARY  (contact)

PROGRAM_OFFICER_NAME: RODRICK, DAVID

PROJECT_TITLE: A Human Factors Approach to Mitigating Speech Communication Interference in the Operating Room

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: PHILADELPHIA

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative The meniscus plays a vital role in knee function and is prone to injury, but the cellular mechanisms regulating its development, maturation and maintenance are poorly understood. This project seeks to fill this knowledge gap by elucidating the role of cellular force generation and mechanosensing in regulating embryonic meniscus patterning, cell fate determination and matrix specialization during embryonic-to-early postnatal growth, and in maintaining cell phenotype in the adult meniscus. Results will establish the mechanobiological basis that regulates the meniscus development and homeostasis, providing new insight to direct regenerative strategies.

PI_NAMEs: DYMENT, NATHANIEL A.;HAN, LIN ;MAUCK, ROBERT L (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Ablation;Actins;Actomyosin;Address;Adult;ATAC-seq;Atomic Force Microscopy;Biological Assay;Birth;Calcium;Cell Fate Control;Cell Separation;Cells;Chromatin;Custom;Cytoskeletal Modeling;Data;Development;Embryo;Embryonic Development;Epigenetic Process;Evaluation;Extracellular Matrix;Family suidae;Feedback;Funding;Generations;Genes;Genetic;Genetic Models;Genetic Transcription;genomic locus;Growth;healing;Heterogeneity;Homeostasis;Human;Hydrogels;Image;Impairment;In Vitro;inhibitor;Injections;Injury;insight;joint formation;Joints;Knee;knock-down;Knowledge;Life Cycle Stages;Limb structure;Maintenance;Matrix Metalloproteinases;mechanical load;mechanical properties;Mechanics;mechanotransduction;Mediating;Meniscus structure of joint;microdevice;Monitor;morphometry;Mus;Muscle;Neonatal;non-muscle myosin;novel;Nuclear;Outcome;Pattern;pharmacologic;Phase;Phenotype;Play;postnatal;Pregnancy;Production;progenitor;Proliferating;regenerative;regenerative approach;Regulation;Role;Shapes;Signal Transduction;single-cell RNA sequencing;Specific qualifier value;Structure;Surgical Models;Tamoxifen;Testing;Time;Tissues;transcriptome sequencing

PROJECT_TITLE: Mechanical Regulation of Cell Fate and Multi-Scale Function in the Developing Meniscus

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunization;Immunotherapy;Vaccine Related

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE T cells are specialized white blood cells that can recognize and destroy tumors in response to cancer immunotherapy treatments. We recently found that a protein called Bhlhe40 is required by T cells for tumor regression in response to immune checkpoint immunotherapy and our goal is to understand how Bhlhe40 regulates T cells to enable them to eliminate tumors under certain conditions. We anticipate this work will provide insights that will lead to development of improved cancer immunotherapies that are needed, as many cancer patients do not experience clinical benefit from current immunotherapy treatments.

PI_NAMEs: GUBIN, MATTHEW M. (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Ablation;Address;Affect;anti-CTLA4;anti-PD-1;antigen-specific T cells;Area;Binding;Binding Sites;Biological Assay;Cancer Control;cancer immunotherapy;Cancer Patient;cancer therapy;Cancer Vaccines;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;cell type;Cells;checkpoint therapy;ChIP-seq;Chromatin;chromatin immunoprecipitation;Clinical;cofactor;conditional knockout;Cytometry;Data;Defect;Development;dimensional analysis;DNA Binding;effector T cell;Epigenetic Process;Exhibits;experimental study;gain of function;Gene Expression;Gene set enrichment analysis;Genes;Genetic Transcription;Goals;high dimensionality;Human;Immune;immune checkpoint;Immunotherapy;improved;improved outcome;innovation;insight;Interferon Type II;Knockout Mice;Knowledge;Leukocytes;Link;loss of function;Luciferases;Macrophage;Malignant Neoplasms;Mediating;Melanoma;Metabolism;Methodology;Modeling;Molecular;Monitor;multiplexed imaging;Mus;mutant;neoantigen vaccine;neoantigens;neoplastic cell;new therapeutic target;novel;Outcome;overexpression;Pathway interactions;Patients;Phenotype;pre-clinical;Pre-Clinical Model;Production;programs;protein protein interaction;Proteins;Publishing;Regulation;Regulatory T-Lymphocyte;Reporter;Resistance;response;Sampling;Sarcoma;single cell ATAC-seq;single-cell RNA sequencing;success;T cell regulation;T-Lymphocyte;Testing;Therapeutic;transcription factor;transcriptomic profiling;transcriptomics;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;Up-Regulation;Vaccine Therapy;Work

PROJECT_TITLE: Bhlhe40 Regulation of T Cell Function During Cancer Immunotherapy

STUDY_SECTION: TIO

STUDY_SECTION_NAME: Translational Immuno-oncology Study Section[TIO]


ADMINISTERING_IC: HL

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: BLACKSBURG

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE Changes in ion channel biophysics due to mutation or disease-associated remodeling are frequently assessed in isolated cells; yet translation of these findings for therapeutic target development is difficult and often fails due to the inherent lack of tissue-scale regulation in isolated cell experimental models. Our prior work has shown that ion concentration changes in extracellular nanodomains adjacent to gap junctions localized at cell-cell junctions (i.e., the intercalated disc) – which are inherently disrupted in isolated cells – regulate cardiac tissue responses in the setting of sodium channel gain-of-function. In this proposal, we will utilize computational modeling (novel structurally detailed tissue models) and experiments (isolated cells, ex vivo hearts, and in vivo genetically- modified mice and peptide-treated guinea pigs) to test the hypothesis that extracellular ion concentrations can serve as biomarkers for electrophysiological responses that are specifically sensitive in settings of genetic and acquired sodium channel gain-of-function, in contrast with current conventional sentiment that extracellular ion concentrations are broad markers of cardiovascular health independent of potential ion channel dysfunction.

PI_NAMEs: POELZING, STEVEN  (contact);WEINBERG, SETH HOWARD

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Action Potentials;Agonist;Agreement;Arrhythmia;Attenuated;Basic Science;Biological;Biological Markers;Biophysics;Blood;Cardiac;Cardiac Electrophysiologic Techniques;cardiovascular health;Cavia;Cell Separation;Cell Size;Cells;Clinical;clinical care;clinically relevant;cofactor;Collection;Computer Models;Computer Simulation;Data;Detection;Development;Diffusion;Disease;Disparate;Electrocardiogram;Electrophysiology (science);Experimental Models;experimental study;extracellular;Feedback;Functional disorder;Future;gain of function;Gap Junctions;Gene Modified;Genetic;Genetically Engineered Mouse;Heart;Homeostasis;Human;human disease;human model;hyperkalemia;Hypernatremia;in silico;in vivo;in vivo evaluation;indium arsenide;Induced Mutation;Intercalated disc;Intercellular Junctions;Intervention;Ion Channel;Ions;Liquid substance;Mannitol;Maps;Measures;Metabolic;Modeling;mouse model;Mus;Muscle Cells;Mutation;nano;Normal Range;novel;Optics;Osmosis;patch clamp;Pathologic;Patients;Peptides;Perfusion;Phenotype;Physiological;Population;Population Study;Post-Translational Protein Processing;Potassium;Potassium Channel;potential biomarker;pre-clinical;Preclinical Testing;Preparation;prevent;Property;Publishing;Regulation;Research;response;Risk;Secondary to;Signal Transduction;simulation;Sodium;Sodium Channel;Structure;Testing;therapeutic target;therapy development;Tissue Model;Tissues;Translating;Translations;Transmission Electron Microscopy;voltage;Width;Work

PROJECT_TITLE: Therapeutic Targeting of Voltage Gated Sodium Channel Autoregulation

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Patient Safety;Prevention;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Women affected by genital fistula experience significant physical and psychosocial morbidity associated with the condition, and nascent evidence suggests subsequent adverse outcomes occur after surgical repair (i.e., fistula repair breakdown or recurrence and incontinence). To identify salient targets for clinical and counselling interventions to improve women’s health and quality of life following fistula repair, we seek to understand the contribution of individual, fistula-related, and post-repair behaviors and exposures to these adverse outcomes. Subsequent and iterative work with key stakeholders will help us develop a road map of intervention strategies likely to be feasible and acceptable within the study population and setting.

PI_NAMEs: EL AYADI, ALISON M (contact)

PROGRAM_OFFICER_NAME: MAZLOOMDOOST, DONNA

PROJECT_TERMS: acceptability and feasibility;Address;adverse outcome;Affect;Africa South of the Sahara;Behavior;Behavioral;Characteristics;Clinical;clinical care;clinical development;clinical examination;Counseling;Data;Enrollment;evidence base;experience;Exposure to;Extravasation;Feces;Female genitalia;Fistula;follow-up;frailty;Genitalia;hazard;improved;Incidence;Incontinence;Individual;Injury;Intervention;intervention mapping;Interview;Joints;Kenya;Knowledge;Longitudinal cohort study;longitudinal design;Medical Records;Modeling;Morbidity - disease rate;Operative Surgical Procedures;Outcome;Participant;Patients;physical symptom;Pregnancy Complications;Pregnancy Outcome;prevent;Prevention;Process;psychosocial;Quality of life;Questionnaires;Recurrence;repaired;Research;Risk;Role;Sample Size;standard of care;Stigmatization;Structure;study population;Symptoms;theories;Theory of Change;Time;Uganda;Urine;Woman;Women's Health;women's outcomes;Work

PROJECT_TITLE: Identifying Opportunities for Prevention of Adverse Outcomes Following Female Genital Fistula Repair

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative Three important responses that influence the outcome of post-viral bacterial pneumonia are: (1) IFN-I signaling that accompanies viral infection, (2) hyperactive inflammation, and antibacterial effects of macrophages and neutrophils, all of which are influenced by T403 phosphorylation of STAT2 induced by viral infection. We will define how T403 phosphorylation of STAT2 exacerbates the severity of post-viral bacterial pneumonia and facilitate novel therapeutic approaches to rebalance the immune response toward antibacterial clearance and away from pneumonia-associated lung injury.

PI_NAMEs: WANG, YUXIN  (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acute Lung Injury;Acute Respiratory Distress Syndrome;Agreement;Alveolar Macrophages;amlexanox;Animal Model;Anti-Bacterial Agents;Anti-viral Response;Antibacterial Response;Bacteremia;Bacteria;Bacterial Infections;Bacterial Pneumonia;Bacteriophages;Biological Markers;Cause of Death;cell type;Cells;Clinical;co-infection;Complication;Confusion;Data;Development;dimer;Equilibrium;Event;extracellular;fighting;Human;Hyperactivity;Immune;Immune response;Impairment;In Vitro;in vivo;Infection;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Influenza A virus;inhibitor;Innate Immune Response;insight;Interferon Type I;Interferons;Invaded;ITGAX gene;Kinetics;Knock-in Mouse;Knowledge;Life;LoxP-flanked allele;Lung;lung injury;Macrophage;Methods;mimetics;Modeling;mortality;Mus;mutant;neutrophil;Neutrophil Infiltration;novel;novel therapeutic intervention;Outcome;pandemic disease;Pathogenesis;Patients;Peptide Initiation Factors;Phagocytosis;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Play;Pneumonia;Predisposition;preservation;Prognosis;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Regulation;Reporting;Respiratory Burst;response;Role;Sampling;Sepsis;Severities;Signal Induction;Signal Transduction;STAT1 gene;Stat2 protein;Structure of parenchyma of lung;TBK1 gene;therapeutic target;Threonine;transcription factor;treatment strategy;Viral;viral pandemic;Viral Physiology;Viral Respiratory Tract Infection;Virus;Virus Diseases;Work

PROJECT_TITLE: The vital role of T403 phosphorylation of STAT2 in post-viral bacterial pneumonia

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Neurosciences

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE The proposed studies aim to substantially advance our basic understanding of how word meaning is represented in the brain. They investigate the extent to which different types of information (sensory-motor, affective, taxonomic, distributional) contribute to the representational code underlying word semantics, and how different cortical regions support those representations. Understanding this complex and particularly human brain system is a necessary step for developing principled and effective interventions for patients with semantic language impairments or speech paralysis, including future therapies involving modulatory stimulation, brain-computer interfaces, and biological repair.

PI_NAMEs: FERNANDINO, LEONARDO F (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Acquired Language Disorders;Affect;Affective;Algorithms;Animals;Aphasia;Area;Auditory;Behavioral;Biological;Body part;Brain;brain based;brain computer interface;Brain Mapping;brain tissue;Categories;Code;Complex;cortex mapping;crowdsourcing;Data;Development;Dimensions;effective intervention;Event;Excision;experience;Fingerprint;Functional Magnetic Resonance Imaging;Future;generative models;Goals;Human;Impairment;Individual;Information Distribution;information model;Judgment;Knowledge;Laboratories;Language Disorders;language impairment;language processing;Lesion;lexical;Machine Learning;Measures;memory process;Modeling;Morphologic artifacts;Motor;neural;Neurobiology;neuroimaging;Neurologic;novel;novel strategies;Paralysed;Participant;Patients;Pattern;Performance;Persons;prevent;Procedures;Prosthesis;random forest;Recurrence;repaired;Rest;Sample Size;Semantics;Sensory;Speech;Structure;System;Tactile;Taxonomy;Techniques;Technology;Testing;theories;Triplet Multiple Birth;Visual;Weight;Word Processing

PROJECT_TITLE: Neural Representation of Lexical Concepts

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Lung;Maternal Health;Maternal Morbidity and Mortality;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative The link between lung health and cardiovascular disease (CVD), the leading cause of death in women in the US, is well-established, and pregnancy is a critical window to intervene on racial-ethnic inequities in lifecourse chronic disease risk in women. Exposure to place-based structural racism may result in a pro-inflammatory state during pregnancy and impair postpartum cardiopulmonary health (CV and lung health) setting the stage for future chronic disease risk. To better understand the mechanisms of action and effect of place-based structural racism during pregnancy on future cardiopulmonary health, we propose Gen C Mamas, a mixed- method longitudinal study of 440 underrepresented and understudied Black, Hispanic, and Asian (Global Majority) women from the Generation C cohort, initially recruited during pregnancy in 2020-2022 in New York City.

PI_NAMEs: JANEVIC, TERESA ;LEE, ALISON G (contact)

PROGRAM_OFFICER_NAME: PRICE, CANDICE

PROJECT_TERMS: Asian;Biological Markers;Birth;Black Populations;Black race;Blood Pressure;Body mass index;Bronchodilator Agents;Buffers;Cardiopulmonary;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cause of Death;Chronic;Chronic Disease;cohort;Communities;critical period;cytokine;Data;Data Collection;Diastolic blood pressure;Dimensions;Discrimination;disease disparity;disease model;disorder risk;Early Intervention;Economics;Education;Environment;environmental justice;ethnic disparity;exhibitions;experience;Exposure to;Female;Focus Groups;Forced expiratory volume function;Future;Generations;Glycosylated hemoglobin A;Goals;Health;health inequalities;Heart Rate;Hispanic;Hispanic Populations;Housing;Hypertension;Impairment;Inequity;Inflammaging;Inflammation;Inflammatory;Infrastructure;Interleukin-6;Law Enforcement;Life;Life Cycle Stages;Link;Lived experience;Long-Term Effects;Longitudinal Studies;lung health;Maps;Maternal Health;Measures;Mediating;Methods;middle age;Modeling;Morbidity - disease rate;mortality;Mothers;multiple chronic conditions;Narration;New York City;novel;pandemic disease;Participant;Pathway interactions;physiologic stressor;Postpartum Period;Pregnancy;Premature Birth;prenatal;Prevalence;Prevention strategy;primary outcome;Process;Production;psychosocial stressors;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Race;racial disparity;recruit;Research;residence;resilience;respiratory;response;Risk Factors;Role;segregation;sex;socioeconomics;stressor;Structural Racism;Subgroup;Sympathetic Nervous System;Testing;theories;Time;Transcend;Transcript;treatment strategy;United States;Vital capacity;Woman;Women's mortality

PROJECT_TITLE: The impact of structural racism during pregnancy on future cardiopulmonary health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-J (96)]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Machine Learning and Artificial Intelligence;Microbiome;Nutrition;Pediatric;Prevention;Sleep Research

ORG_CITY: ROCHESTER

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE This project fills 4 crucial public health gaps: 1) how breast milk changes over time and over the day, 2) how milk dynamics effect infant sleep patterns, 3) how milk dynamics effect infant microbiome dynamics, and 4) how all these relationships differ between infants fed directly at-the-breast vs pumped milk. These fundamental insights have been unknown until now, so that families who feed pumped breast milk are completely underserved. These results are critical to optimizing infant feeding and health outcomes for all infants receiving breast milk.

PI_NAMEs: YOUNG, BRIDGET VICTORIA (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: actigraphy;Address;Algorithms;Biofeedback;biological systems;Biology;Biometry;Breast;Breast Feeding;breast pump;Chronobiology;Clinical;Cognitive;complex biological systems;cytokine;Data;design;Development;Ecosystem;Exclusive Breastfeeding;Exhibits;Family;Feedback;feeding;Future;Growth;Growth and Development function;Guidelines;Health;Hormones;Hour;Human Milk;Hydrocortisone;Immune;Immunoglobulin A;Immunoglobulins;Immunologic Factors;improved;Individual;Infant;Infant Development;Infant Health;infant nutrition;infant outcome;insight;Interruption;Leptin;Life;Link;Machine Learning;machine learning algorithm;machine learning model;Macronutrients Nutrition;Measures;Metadata;Microbe;microbial colonization;microbiome;microbiota;Milk;Milk Banks;milk expression;Modeling;Mothers;multiple omics;novel;Nutrient;nutrition;Oligosaccharides;Outcome;Pattern;Postpartum Period;precision nutrition;Premature Infant;Protocols documentation;Public Health;Pump;Research;Research Personnel;Resolution;Sampling;Series;Signal Transduction;Sleep;sleep pattern;smartphone application;Source;suckling;supervised learning;System;Techniques;Time;Variant;wearable device

PROJECT_TITLE: Improving Infant Health by Studying Human Milk as a Biological System: Composition, Dynamics, and Delivery (At-the-Breast vs Expressed Milk) (BEGIN)

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Brain Disorders;Down Syndrome;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: WORCESTER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE This proposal directly addresses the need for new pharmacological treatments to prevent intellectual disability in Down syndrome. Defining how human chromosome 21 genes interact synergistically to drive abnormal brain development and function will reveal critical underlying pathways and new protein targets. Using the high- throughput larval zebrafish will support systematic characterization of many genetic contributions and discovery of lead molecules through whole-organism compound screening.

PI_NAMEs: THYME, SUMMER B (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Address;Affect;Anatomy;Animal Model;Animals;Behavior;behavioral phenotyping;Binding Proteins;Biological Assay;Brain;brain abnormalities;Cell Culture Techniques;cell type;Cells;Characteristics;Chromatin;Chromosome 21;Clinical Trials;Code;Competence;Complex;Computing Methodologies;CRISPR-mediated transcriptional activation;Defect;Development;Developmental Biology;Developmental Process;Disease;dosage;Down's Syndrome;drug discovery;Drug Screening;Drug Targeting;Embryonic Development;epigenome;Epilepsy;Erinaceidae;FDA approved;Foundations;Future;Gene Expression Profile;gene function;gene interaction;Genes;Genetic;Genetic Diseases;Genetic study;Genetic Transcription;Genomics;Goals;HMGN1 gene;Human;Human Chromosomes;Human Genetics;Individual;innovation;Intellectual functioning disability;Investigation;Knowledge;Lead;Maps;Mediating;Methods;Mitogens;Modeling;Molecular;mouse genetics;mouse model;Mus;mutant;Natural Products;Nervous System;neural;neurodevelopment;Neurodevelopmental Deficit;Neurodevelopmental Disorder;Neurophysiology - biologic function;novel;novel strategies;Optics;Outcome;overexpression;Pathway interactions;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pharmacotherapy;Phenotype;prevent;Prevention;Process;programs;Proteins;Publishing;Reporting;Research;Resolution;response;Role;Schizophrenia;screening;Shapes;SHH gene;Signal Pathway;Signal Transduction;single-cell RNA sequencing;small molecule;smoothened signaling pathway;stem;Structure;Surveys;Testing;Trisomy;Whole Organism;Work;Zebrafish;zebrafish development

PROJECT_TITLE: Large-scale Genetic Investigation and Drug Discovery to Counteract Down Syndrome Neural Deficits

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-B (57)]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Gene Therapy;Genetics;Immunotherapy;Neuroblastoma;Neurosciences;Orphan Drug;Patient Safety;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: Narrative We seek to develop and test in animal models a strategy to prevent metastatic disease from solid tumors and treat existing micrometastatic disease. We are leveraging the new era of systemically administered gene therapy, originally developed for treating genetic disorders, to achieve continuous, long-term expression of an immunotherapy, thus exerting constant pressure on the cancer cells and reducing their chances to develop resistance and escape from therapy. If successful, our work will lead to clinical trials and potential markedly reduce the burden of cancer by leading to prolonged patient survival.

PI_NAMEs: CRIPE, TIMOTHY P (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Animal Model;anti-cancer;Antibodies;bi-specific T cell engager;Blood Circulation;Bone Marrow;Brain;Cancer Burden;cancer cell;cancer genome;cancer type;Carbohydrates;CD19 gene;CD3 Antigens;Cell surface;Cell Survival;Cells;cellular transduction;Cessation of life;chemotherapy;Circulation;clinical translation;Clinical Trials;Data;design;Development;Diagnosis;Disease;Disease remission;Distant;Dose;Drug resistance;effector T cell;efficacy study;Event;Extravasation;FDA approved;Future;Gene Expression;gene product;gene therapy;gene transfer vector;Genetic Diseases;Half-Life;Human;humanized mouse;Image;Immune Targeting;immunogenicity;Immunologic Surveillance;Immunologics;Immunotherapy;improved;Intravenous;intravenous injection;Long-Term Effects;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Medical;Micrometastasis;Microscopic;Modeling;Neoadjuvant Therapy;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;Neuroblastoma;Normal Cell;Organ;Patients;Pediatric Neoplasm;Pharmaceutical Preparations;Phase;Pre-Clinical Model;pressure;prevent;Primary Neoplasm;Process;Prognosis;Proteins;Publishing;Recombinant adeno-associated virus (rAAV);Recovery;Relapse;Residual Neoplasm;Resistance development;safety study;safety testing;Schedule;Signal Transduction;Site;Solid Neoplasm;System;Systemic Therapy;T-Lymphocyte;Technology;Testing;therapy resistant;Time;Toxic effect;Transgenes;tumor;Tumor Antigens;tumor microenvironment;vector;viral DNA;Work

PROJECT_TITLE: A New Paradigm to Prevent and Treat Micrometastases


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Although estrogen decreases in all women during menopause, an increase in blood pressure occurs in many, but not all women. The factors affecting whether and by how much the blood pressure increases during menopause are unknown. This project investigates changes during women’s midlife in a hormonal system called the renin-angiotensin-aldosterone system, with findings likely to change ideas about optimal treatment of high blood pressure in older women.

PI_NAMEs: BYRD, JAMES BRIAN (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Affect;Aldosterone;Angiotensin Receptor;Angiotensin-Converting Enzyme Inhibitors;Angiotensinogen;antagonist;Anti-Hypertensive Agents;Biometry;Blood Pressure;blood pressure elevation;blood pressure regulation;Cardiac;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Cause of Death;Cessation of life;Chronic Kidney Failure;CYP11B2 gene;Data;Development;Diabetic Nephropathy;Endocrine system;Epidemiology;epidemiology study;Estrogen decline;Estrogens;Event;experience;Failure;Female;follow-up;Glomerular Filtration Rate;Goals;Health;Hormones;Hypertension;hypertension treatment;improved;Individual;inhibitor;insight;Kidney;Life;Link;Logistic Regressions;Longitudinal Studies;male;Mass Spectrum Analysis;Measurement;Measures;men;Menopause;Menstruation;Midlife women;Mineralocorticoid Receptor;Modeling;mortality;Myocardial Infarction;neglect;novel;novel therapeutics;older women;optimal treatments;Outcome;Patients;Perimenopause;Pharmaceutical Preparations;Plasma;Population;Postmenopause;Prevalence;prevent;Production;Renin;Renin-Angiotensin-Aldosterone System;Resistant Hypertension;revascularization;Risk;Role;Sampling;Serum;Statistical Models;Stroke;System;Testing;Time;United States;Visit;Woman;Women's mortality;Women's study

PROJECT_TITLE: Aldosterone and the menopausal transition's increase in blood pressure and cardiovascular risk

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative We develop new methods for enhancing models that can predict behavior, clinical status, and other outcomes using neuroimaging data. This will promote the development of neuromarkers for neurobiological processes underlying symptoms in clinical settings and everyday life, providing targets for experimental manipulations and interventions, from cognitive and behavioral treatments to drugs to neurostimulation.

PI_NAMEs: DATTA, ABHIRUP ;LINDQUIST, MARTIN  (contact);WAGER, TOR D.

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Address;Anatomy;Architecture;Area;Behavior;behavior prediction;Behavior Therapy;behavioral outcome;Brain;Brain imaging;Brain Mapping;Brain region;Categories;Clinical;cognitive performance;Cognitive Therapy;Data;data acquisition;Data Set;design;Development;diverse data;experience;Face;Feeling;Functional Magnetic Resonance Imaging;Geometry;Grant;Hour;Human;improved;Individual;Individual Differences;Intervention;Life;Location;Maps;mental state;Methodology;Methods;Modeling;Modernization;multi-scale modeling;neural;Neurobiology;neuroimaging;Neurologic;novel;Outcome;Pain;Participant;Pattern;Pharmaceutical Preparations;Population;predictive modeling;preservation;Procedures;Process;Psyche structure;response;Semantics;Shapes;Space Models;Stimulus;Structure;Symptoms;System;Testing;Time;tool;Validation;Work

PROJECT_TITLE: Individualized spatial topology in functional neuroimaging

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: NARRATIVE We aim to harmonize and link large-scale cross-sectional and panel survey data from a population of underserved service-sector workers during the pandemic with establishment- and area-level data and to make this integrated dataset openly available for research. We will use this linked data to estimate the degree to which the expanded safety net buffered any negative effects of unemployment on health during the pandemic. We also propose to examine the influence of both public and company policies on masking and paid sick leave on adherence to coronavirus mitigation practices, and how these relationships vary by age.

PI_NAMEs: HARKNETT, KRISTEN ;SCHNEIDER, DANNY  (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Adherence;Adult;Affect;Age;aged;Area;Asian;Behavior;Behavioral Sciences;Black race;Buffers;Characteristics;Common Data Element;Communities;Coronavirus;COVID-19;COVID-19 monitoring;COVID-19 pandemic;COVID-19 prevalence;COVID-19 susceptibility;Data;Data Files;data integration;data repository;data resource;Data Set;Databases;Documentation;Economics;Effectiveness;Employee;Environment;Ethnic Origin;evidence base;experience;Experimental Models;Food Services;future pandemic;geographic difference;Grain;Health;health disparity;Health Sciences;high risk;Hispanic;Home;hospital services;Household;Income;innovation;Interview;Job loss;Knowledge;Labor Forces;large scale data;Life Cycle Stages;Link;Location;Low income;Maps;Masks;Measures;Modeling;Nature;novel;nutrition;older adult;Outcome;pandemic disease;people of color;Personal Satisfaction;Persons;Pharmacy facility;Policies;Population;programs;Public Health;public health relevance;Public Policy;Quasi-experiment;Race;Research;Research Personnel;response;Risk;Role;safety net;Sampling;Services;Shapes;Shock;Sick Leave;Site;Social Sciences;socioeconomic disadvantage;Subgroup;Surveys;Time;Underserved Population;Unemployment;unemployment insurance;Variant;vulnerable community;Woman;Workplace

PROJECT_TITLE: COVID-19 and the Health and Wellbeing of Vulnerable Service Sector Workers across the Life Course

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities

PHR: PROJECT NARRATIVE Hypothyroidism is a common disorder that requires lifelong treatment with thyroid hormone replacement. Many patients with hypothyroidism still have hypothyroid symptoms while taking standard-of-care therapy with levothyroxine at recommended doses. This proposal will generate pilot and feasibility data required to design a large randomized, placebo-controlled trial of combination therapy with levothyroxine and liothyronine in patients with hypothyroidism who have residual symptoms.

PI_NAMEs: CAPPOLA, ANNE R (contact)

PROGRAM_OFFICER_NAME: BURCH, HENRY B

PROJECT_TERMS: absorption;Address;Affect;Autoimmune;Clinical;clinical practice;Clinical Trials;Combined Modality Therapy;Conduct Clinical Trials;Consent;Controlled Clinical Trials;cost;Data;design;Disease;Dose;Double-Blind Method;Drug Prescriptions;effectiveness evaluation;Ensure;Etiology;Evaluation;evidence base;experience;Foundations;Genetic Polymorphism;Goals;Guidelines;Health;Health Expenditures;Human;Hypothyroidism;Impairment;Individual;International;Lead;Marketing;medication compliance;Metabolism;Minority;Mission;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Oral;outreach;Patients;Persons;Pharmaceutical Preparations;Physiological;Physiology;Pilot Projects;Placebo Control;placebo group;Placebos;Population;Preparation;primary outcome;Procedures;Production;Protocols documentation;Randomized;randomized placebo controlled trial;Recommendation;recruit;Regimen;Replacement Therapy;Research;Research Personnel;Residual state;response;Safety;Sample Size;secondary outcome;Severities;Sodium;Sodium Chloride;standard of care;study population;Subgroup;Symptoms;Tablets;Thyroid Gland;Thyroid Hormones;Thyroidectomy;Thyrotropin;Thyroxine;Triiodothyronine;Well in self;Withdrawal;Work

PROJECT_TITLE: T4/T3 Therapy in Hypothyroidism

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Bioengineering;Congenital Structural Anomalies;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project narrative The goal of this project is to understand the cellular, molecular and mechanical basis of body axis formation during embryonic development. This knowledge is expected to impact our understanding of birth defects of the trunk and limbs and could shed light on the biology of cancer.

PI_NAMEs: POURQUIE, OLIVIER  (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: 3-Dimensional;Anterior;biophysical analysis;Birds;Cancer Biology;CD44 gene;cell motility;Cells;Chick Embryo;Congenital Abnormality;convergent extension;Data;Development;Diffusion;Disaccharides;Embryo;Embryonic Development;Epithelium;Etiology;experimental study;extracellular;Extracellular Matrix;Extracellular Space;Fibroblast Growth Factor;gastrulation;Gel;Generations;Genetic;genetic manipulation;Glycosaminoglycans;Goals;Growth;Head;high resolution imaging;Human;human induced pluripotent stem cells;human model;Hyaluronic Acid;In Vitro;in vivo;induced pluripotent stem cell;Intercalated Cell;Knowledge;Limb structure;Maintenance;malformation;Mammals;mechanical properties;Mechanics;Mediating;Mesoderm;Mesoderm Cell;Modeling;Modification;Molecular;Morphogenesis;Motility;Movement;Musculoskeletal System;mutant;Neural tube;novel;novel strategies;Organoids;Paraxial Mesoderm;Physics;Play;Polymers;Population;pressure;Primitive Streaks;Process;receptor;Regulation;Reporter;response;Role;Signal Transduction;single-cell RNA sequencing;Skeletal Muscle;Somites;somitogenesis;Spinal Dysraphism;spine bone structure;Structure;Swelling;System;Tail;Temperature;Testing;three-dimensional modeling;Tissues;vertebrate embryos;viscoelasticity;Work

PROJECT_TITLE: Mechanics of Vertebrate Embryo Elongation

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ORG_CITY: LITTLE ROCK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE Public Health Relevance: High blood pressure, also known as hypertension, is a serious condition that needs to be treated because it can lead to stroke, heart attack, and organ failure. Our research has discovered, for the first time, how certain immune cells called T cells are activated and move into the kidneys during the early stage of hypertension, and become long-lasting memory cells resident in the kidney, which contribute to the progression of hypertension and hypertensive memory of salt-sensitivity. By understanding the important molecules involved in this process, we can identify new targets for developing treatments for hypertension.

PI_NAMEs: MU, SHENGYU  (contact)

PROJECT_TERMS: adaptive immune response;Address;Animals;Anti-Hypertensive Agents;Antigens;Attenuated;autocrine;Autocrine Communication;Automobile Driving;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure regulation;Calcium;Cardiovascular Diseases;cardiovascular risk factor;CD8-Positive T-Lymphocytes;Cell membrane;Cells;Clinical;cytokine;defined contribution;Development;Distal convoluted renal tubule structure;effective therapy;Event;experimental study;extracellular;Feedback;Future;Gene Deletion;Genetically Modified Animals;Homeostasis;Homing;Hypertension;hypertension control;hypertension treatment;hypertensive;Immune;Immune System Diseases;Immunologic Memory;Immunotherapy;Impairment;In Vitro;in vivo;Infiltration;innovation;Kidney;Knock-out;Knockout Mice;Knowledge;Maintenance;Mature T-Lymphocyte;Mediating;Memory;Molecular;mortality;mouse model;Mus;Myocardial Infarction;normotensive;novel;Organ failure;Pathogenesis;Pathway interactions;Patient Compliance;Pharmaceutical Preparations;Play;prevent;Process;Public Health;public health relevance;Purinoceptor;receptor;Recurrence;Renal Hypertension;Reporting;Research;Residencies;Risk Factors;Role;salt sensitive;salt sensitive hypertension;Signal Transduction;Signaling Molecule;Sodium;Sodium Chloride;Stroke;T cell infiltration;T memory cell;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;therapeutic target;Time;Tissues;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;Transplantation;treatment strategy

PROJECT_TITLE: T cell homing to the kidney contributes to salt retention and blood pressure regulation

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Dental, Oral, and Craniofacial Disease;Headaches;Migraine;Neurosciences;Pain Research

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE In spite of the development of new treatments, we still have only a poor understanding of the mechanisms of migraine. One basic question is whether the headache phase of migraine depends on processes occurring in the peripheral or the central nervous system. Clarifying this question has the potential to alter the focus of treatment as well as drug development to central targets in combination with peripherally acting drugs.

PI_NAMEs: STRASSMAN, ANDREW MARK (contact)

PROGRAM_OFFICER_NAME: OSHINSKY, MICHAEL L

PROJECT_TERMS: Address;Afferent Neurons;Anesthesia procedures;Auras;Bilateral;Cell Nucleus;Central Nervous System;Cephalic;Complex;Contralateral;Development;Dorsal;dorsal horn;drug action;drug development;Event;experimental study;Face;Female;Ganglia;Generations;Handedness;Headache;Ipsilateral;Lateral;male;Mandible;Meningeal;Meninges;Migraine;nerve supply;neural;Neurons;Nociception;Nociceptors;novel;Pain;Pathway interactions;Peripheral;Peripheral Nervous System;Phase;Play;Population;Process;Prosencephalon;Rattus;receptive field;Research;response;Role;Seizures;Sensory;sensory cortex;sensory input;Side;Spreading Cortical Depression;Structure;Structure of trigeminal ganglion;symptomatology;Testing;Thalamic Nuclei;Thalamic structure;Time

PROJECT_TITLE: Central vs. Peripheral Mechanisms of Headache: Cortex, Thalamus, Dorsal Horn

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-T (02)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: OXFORD

ORG_DEPT: BIOLOGY

ORG_NAME: MIAMI UNIVERSITY OXFORD

PHR: Project Narrative Studying model organisms with superior regenerative capacities, such as the newt, could uncover critical mechanisms that have been long-coveted for regenerative therapeutics. In this proposal, we will use cutting- edge techniques to dissect the precise molecular roadmap that enables newt iris cells to replace lost lenses. In doing so, we will reveal regeneration secrets never before disclosed.

PI_NAMEs: DEL RIO-TSONIS, KATIA  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Acute;Address;Adult;Amphibia;ATAC-seq;Atlases;cell injury;Cell Nucleus;cell regeneration;Cell Reprogramming;cell type;Cells;Chromatin;combat;Competence;Complement;Crystalline Lens;Crystallins;Cues;Data;Data Set;Development;Dorsal;Environment;Ephrins;Epigenetic Process;Epithelial Cells;Event;Excision;Eye;Eye Development;Eye diseases;Foundations;Future;gene conservation;Gene Expression;gene regulatory network;Gene Transfer Techniques;Generations;Genes;Genetic;Genetic Markers;Genome;Home;in vivo;Individual;injured;Injury;innovation;Intervention;Investigation;Iris;Knowledge;lens;lens regeneration;Light;Maps;Methodology;Methods;model organism;Modeling;Molecular;Morphology;multiple omics;Natural regeneration;Newts;Notophthalmus viridescens;novel;novel therapeutic intervention;Outcome;Pathway interactions;Pattern;pharmacologic;Pigment Epithelium;Pleurodeles;Process;programs;Publishing;reference genome;regeneration model;regenerative;Regenerative capacity;regenerative cell;regenerative therapy;response to injury;rib bone structure;Role;Route;Salamander;Seminal;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;Spanish;spatiotemporal;Sports;stem cells;Structure;Study models;System;Techniques;therapy design;Time;tissue regeneration;transcriptome;transcriptome sequencing;transcriptomics;transdifferentiation;Transgenic Organisms;Vertebrates;Vision;Work

PROJECT_TITLE: Upon Solving the Secrets for Lens Transdifferentiation

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Down Syndrome;Eye Disease and Disorders of Vision;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric

ORG_DEPT: PATHOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative The proposed research is relevant to public health because this work will provide a new perspective on the molecular pathogenesis of Down syndrome (DS), the most common genetic cause of intellectual disability, which will enable the identification of new drug targets and provide an approach to test candidate therapies to prevent developmental delay and cognitive impairment in individuals with DS. The proposed research is relevant to the NIH’s mission “to seek fundamental knowledge about the nature and behavior of living systems and the applica- tion of that knowledge to enhance health, lengthen life, and reduce illness and disability.” This work will also help to achieve goals of the NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndrome (INCLUDE) Project to “improve understanding of the biology of Down syndrome and support development of new treatments for health conditions experienced by individuals with Down syndrome.”

PI_NAMEs: WILLIAM, CHRISTOPHER MAGED (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Adolescent;Age;Alleles;awake;base;Behavior;behavioral phenotyping;biocytin;Biological Assay;Biology;Blindness;Brain;brain circuitry;Cells;cognitive function;Complement;Coupled;Cre lox recombination system;critical period;Data;Defect;design;Development;Developmental Delay Disorders;disability;Down's Syndrome;Drug Targeting;Electrophysiology (science);excitatory neuron;experience;experimental study;Eye;Fluorescence;Functional disorder;Gene Expression;Genes;Genetic;Goals;Head;Health;Hippocampus;Immediate-Early Genes;Impaired cognition;Impairment;improved;In Vitro;Individual;inhibitor;inhibitory neuron;Intellectual functioning disability;Investigation;Knowledge;Label;laser capture microdissection;Lasers;Life;life span;Mass Spectrum Analysis;Measures;Mediating;Microscopy;Mission;Modeling;Molecular;monocular deprivation;Morphology;mouse model;mouse Ts1Rhr;mouse Ts65Dn;Mus;Nature;neural circuit;Neurons;new therapeutic target;novel;Ocular Dominance;optical imaging;Organism;patch clamp;Pathogenesis;Persons;pharmacologic;Phenotype;phosphoproteomics;Phosphorylation;Phosphotransferases;Photic Stimulation;Physiological;Physiology;Play;postnatal;prevent;Process;Proteins;Public Health;Research;response;restoration;Role;Sampling;Signal Transduction;Slice;Specificity;Study models;Testing;Trisomy;Tyrosine Phosphorylation;United States National Institutes of Health;Visual Cortex;Visual System;Work

PROJECT_TITLE: Establishing the role of Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A trisomy in juvenile plasticity impairment in Down Syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-B (56)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: NARRATIVE The proposed studies focus on schistosomiasis, a significant, unmet medical need in 78 endemic countries, with more than 200 million people infected, 20 million with significant morbidity, and more than 200,000 deaths annually. Current schistosomiasis control strategies rely almost exclusively on chemotherapy; there is only one available drug and it is inevitable that drug-resistant parasites will evolve. The proposed research will exploit differences in redox defenses between schistosome worms and humans to discover and optimize small molecule inhibitors to selectively disrupt worm redox for new treatments for schistosomiasis.

PI_NAMEs: ANGELUCCI, FRANCESCO ;PETUKHOV, PAVEL A (contact);WILLIAMS, DAVID LEE

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Adolescent;Adsorption;Adult;Animal Model;Antioxidants;ATP-Binding Cassette Transporters;Binding;Biochemical;Biochemistry;Biological Assay;Biological Availability;Cells;Cessation of life;Chemicals;chemotherapy;Chronic disability;Chronic Disease;Clinical;comparative efficacy;Complex;Computer Assisted;Computer-Aided Design;Country;Cryoelectron Microscopy;design;Development;Disease;Disease Resistance;Drug Design;drug development;drug discovery;Drug Efflux;Drug Kinetics;drug metabolism;Drug resistance;Drug Targeting;enzyme activity;Enzymes;Evolution;Excretory function;experimental study;follow-up;Follow-Up Studies;Formulation;Funding;glutaredoxin;Glutathione Reductase;Goals;high throughput screening;Human;improved;in silico;In Vitro;in vivo;Infection;inhibitor;Lead;lead optimization;Lethal Dose 50;Libraries;Ligands;Mammalian Cell;Measures;Mediator;Medical;meetings;member;Metabolic;Metabolism;Molecular;Molecular Target;Molecular Weight;Morbidity - disease rate;Mus;NADP;neglect;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Oral;oxidation;Oxidation-Reduction;Parasite resistance;Parasites;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Plasma;Praziquantel;Praziquantel resistance;preclinical study;Program Development;Property;Protein Family;Proteins;Recombinant Proteins;Research;Research Design;Resolution;RNA Interference;Roentgen Rays;Schistosoma;Schistosoma mansoni;Schistosome Parasite;Schistosomiasis;Schistosomicides;screening;Selenocysteine;Seminal;small molecule inhibitor;Solubility;standard of care;structural biology;Structure;Therapeutic;thioredoxin reductase;Toxic effect;TXN gene;United States National Institutes of Health;Vertebrates;X-Ray Crystallography

PROJECT_TITLE: Development of novel TGR inhibitors for the treatment of schistosomiasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-U (90)]


NIH_SPENDING_CATS: Cardiovascular;Neurosciences

ORG_CITY: JOHNSON CITY

ORG_NAME: EAST TENNESSEE STATE UNIVERSITY

ORG_STATE: TN

PHR: Vagal nerve stimulation therapy has been approved for three central nervous system disorders but large patient trials for heart failure have failed despite promising preclinical evidence of success. We propose that appropriate consideration of vagal afferent central transmission is key to designing optimally effective therapeutic protocols for vagal nerve stimulation. Our preliminary evidence suggests that signals from the paraventricular nucleus of the hypothalamus contribute to therapeutic efficacy in heart failure.

PI_NAMEs: BEAUMONT, ERIC  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Action Potentials;Address;Afferent Neurons;Animals;Axon;Biological Assay;Brain;Brain Stem;Cardiovascular Diseases;Cellular Assay;Central Nervous System;Central Nervous System Diseases;Cervical;Chronic;Clinical;clinical application;Clinical Protocols;Communication;Coughing;Couples;Data;design;Diagnosis;Drug resistance;Effectiveness;Evaluation;evidence base;experience;Experimental Designs;experimental study;Failure;Foundations;Frequencies;Goals;Halorhodopsins;Heart failure;heart failure with reduced ejection fraction;Hypothalamic structure;improved;In Vitro;insight;Knowledge;Light;Link;Measures;Mental Depression;Minority;Modeling;Nerve;Neurons;Neuropeptides;neuroregulation;Nucleus solitarius;optimal treatments;optogenetics;Outcome;Oxytocin;Pain;paraventricular nucleus;patch clamp;Pathway interactions;Patients;Pattern;Peripheral;Physiology;pre-clinical;Process;Property;Protocols documentation;Rattus;Recommendation;recruit;Research;Resolution;Role;Sensory;Shock;side effect;Signal Transduction;skills;Slice;Stimulus;success;synaptic depression;Synaptic Transmission;Therapeutic;therapeutically effective;therapy design;therapy outcome;Titrations;tool;Transfection;transmission process;Treatment Efficacy;Vagus nerve structure;Vasopressins;Visceral Afferents;Voice;Work

PROJECT_TITLE: Afferent Mechanisms of Vagal Neuromodulation Therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-Q (91)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Disability Research;Down Syndrome;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: AUSTIN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE Little is known about how language and motor skills interact in the early development of infants with Down Syndrome (DS). This project will follow infants (6 to 18 months) with and without DS for 12 months to measure language and motor trajectories using a multiple-method approach. The results from this study will inform intervention priorities and strategies to support early development in DS.

PI_NAMEs: FLORES, MEGAN ;VANEGAS, SANDRA  (contact)

PROJECT_TERMS: Accelerometer;actigraphy;Adaptive Behaviors;Address;Affect;African American;Age;Asian;Assessment tool;Black race;Caregivers;Caring;Child;Chromosome 21;cognitive disability;Communication;Communities;Complex;congenital heart abnormality;culturally appropriate intervention;Data;Development;Developmental Disabilities;Developmental Process;Down's Syndrome;early childhood;Enrollment;Environment;ethnic diversity;ethnic minority;Family;Floor;Funding;Genetic Diseases;Gestures;Goals;grasp;Hearing problem;Hispanic;improved;Infant;Infant Development;Intervention;Knowledge;Language;Language Development;Latino;Literature;Measurement;Measures;Methods;Motor;Motor Skills;Movement;Muscle hypotonia;Native Americans;neglect;Outcome;Parents;Participant;Physical activity;physically handicapped;Play;Population;Questionnaires;racial diversity;racial minority;Recommendation;recruit;Recruitment Activity;Reporting;Research;response;Sampling;skills;Speech Delay;Standardization;Technology;Time;Toddler;trend;United States;United States National Institutes of Health;Validation;Vision;vocalization

PROJECT_TITLE: Characterizing Language and Motor Development of Racially/Ethnically Diverse Infants and Toddlers with Down Syndrome


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Social Determinants of Health;Telehealth

ORG_CITY: Aurora

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Although parenting interventions can improve the mental health and well-being for both parents and their young children, these intended benefits do not occur for many families. This proposed K23 study will use a prospective, single-arm clinical trial to evaluate potential predictors (i.e., parental executive functioning difficulties and adverse social determinants of health) of suboptimal response and then use mixed methods approaches to identify potential intervention adaptations driven by parent and clinician input. Findings will guide the next R01 proposal testing if adaptations identified within this K23 proposal enhance the effectiveness of parenting interventions at improving parent (e.g., harsh parenting, parenting stress) and child outcomes (e.g., externalizing concerns, irritability).

PI_NAMEs: HOLZMAN, JACOB  (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: 7 year old;Address;Adult;Adverse event;Affect;Area;arm;attentional control;Behavioral;career;Characteristics;Child;Child Rearing;Clinical Trials;cognitive control;Competence;Data;Dedications;Dose;early childhood;Early treatment;effective intervention;Effectiveness;Effectiveness of Interventions;Emotional;Emotions;Equity;Event;executive function;experience;Family;flexibility;Foundations;Goals;Head Start Program;help-seeking behavior;improved;Individual;informant;innovation;Intervention;intervention effect;Interview;Knowledge;Learning;Life;Link;Measurement;Measures;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentorship;Methodology;Methods;Outcome;Parent-Child Relations;parental influence;parental role;parenting intervention;Parents;Pediatric Hospitals;Personal Satisfaction;Persons;Population;Problem behavior;Process;programs;prospective;recruit;Reporting;Research;Research Methodology;Research Project Grants;response;Role;Scientist;Site;skill acquisition;social health determinants;Stress;telehealth;Testing;Training;translational approach;Treatment outcome;treatment response;Work;Youth

PROJECT_TITLE: Stop, focus, plan, and change: A translational approach to predict parent and child responses to a brief, telehealth parent training

STUDY_SECTION: EMHI

STUDY_SECTION_NAME: Effectiveness of Mental Health Interventions Study Section[EMHI]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Data Science;Dental, Oral, and Craniofacial Disease;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine

ORG_CITY: INDIANAPOLIS

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Chronic rhinosinusitis is estimated to affect 10-12% of American adults and is one of the top ten most costly medical conditions in the United States. It is associated with severe but variable quality of life detriment, and this study’s focus on individualized treatment outcomes will help understand receptiveness to machine learning/artificial intelligence in clinical care, illuminate disease phenotypes, inform personalized clinical decision-making, and improve patient satisfaction. The proposed research is relevant to the part of the NIH’s mission to develop fundamental knowledge that will enhance health, reduce illness and disability, and enhance quality of life.

PI_NAMEs: RAMAKRISHNAN, VIJAY  (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Adoption;Adult;Affect;Aftercare;Airway Disease;Algorithms;Allergic rhinitis;American;Anosmia;Anxiety;Artificial Intelligence;Asthma;Caring;Characteristics;Chronic;Chronic Disease;Chronic Obstructive Pulmonary Disease;chronic rhinosinusitis;Client satisfaction;Clinical;clinical application;clinical care;Clinical Data;clinical decision support;clinical decision-making;clinical practice;clinical predictors;clinically actionable;Complex;Congestive Heart Failure;cost;Cost-Benefit Analysis;Cystic Fibrosis;Data;Data Science;Data Set;data visualization;Decision Making;Development;disability;Disease;Disease Management;disease natural history;disease phenotype;Drainage procedure;Effectiveness;End stage renal failure;expectation;experience;Fatigue;Financial Hardship;Goals;Headache;Health;Human;human-in-the-loop;Impaired cognition;Impairment;implementation facilitation;implementation science;improved;Individual;individual patient;individualized medicine;informatics tool;innovation;Intervention;Interview;iterative design;Kidney Diseases;Knowledge;learning strategy;Machine Learning;Measures;Medical;Medical Care Costs;Mental Depression;Methods;Mission;multidisciplinary;Nose;novel;Observational Study;Operative Surgical Procedures;Otolaryngology;Outcome;outcome prediction;Outcome Study;Patient Care;patient expectation;patient oriented;Patients;Pattern;personalized approach;personalized decision;personalized management;personalized medicine;personalized predictions;personalized therapeutic;Pharmaceutical Preparations;Phenotype;Physicians;Population;precision medicine;prediction algorithm;Predictive Analytics;predictive modeling;preference;productivity loss;prospective;prototype;Quality of life;recurrent infection;reduce symptoms;Reporting;Research;Resources;Respiration Disorders;Respiratory Disease;response;Risk;Risk Factors;Role;Severities;Severity of illness;shared decision making;sharing platform;Sinus;skills;sleep difficulty;Sleep Disorders;Structure;support tools;Symptom Burden;symptomatic improvement;Symptoms;System;Techniques;Testing;Therapeutic;Time;Translating;translational impact;Translations;treatment center;treatment disparity;Treatment outcome;treatment planning;Trust;United States;United States National Institutes of Health;user centered design;Visit;Work

PROJECT_TITLE: The Chronic Rhinosinusitis (CRS) Problem and an AI Driven Personalized Medicine Solution

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: PROJECT NARRATIVE The synaptic vesicle protein 2 (SV2) family is crucial for proper neurotransmission and is the molecular target for two clinical antiepileptic drugs. Mutations in human SV2 are linked to epilepsy, and deletion of the SV2 gene in mice causes severe seizures and death. Understanding the structures, functions and molecular mechanisms of this important protein family will lead to new therapies for epilepsy.

PI_NAMEs: LEE, CHIA-HSUEH  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Address;anti-epileptic agents;Architecture;Binding;Binding Sites;Biochemical;Biological Assay;Biology;biophysical techniques;Botulinum Toxins;Brain;Cells;Cessation of life;Chemicals;Chimeric Proteins;Clinical;Communication;Complex;Cryoelectron Microscopy;Defect;Drug Design;Drug Interactions;Drug Targeting;Ensure;Epilepsy;extracellular;Family;flexibility;Fluorescence;Foundations;Functional disorder;Future;Genes;Glycoproteins;Goals;Human;Impaired cognition;improved;in vitro Assay;in vivo;insight;Integral Membrane Protein;interdisciplinary approach;Investigation;Knowledge;Levetiracetam;Link;Mass Spectrum Analysis;Mediating;Medicine;Membrane Proteins;Mental disorders;metabolomics;Molecular;Molecular Conformation;Molecular Target;Mus;Mutation;Nature;Nerve Degeneration;Nervous System Disorder;neuron component;Neurons;neurotransmission;neurotransmitter release;Neurotransmitters;next generation;novel therapeutics;Organelles;particle;Pathway interactions;Pharmaceutical Preparations;Pharmacology;Phylogenetic Analysis;Physiological;Physiology;Play;Positioning Attribute;positive allosteric modulator;Protein Family;Protein Isoforms;Proteins;proteoliposomes;radioligand;rational design;Recombinants;Regulation;Research;Resistance;Resolution;Rodent;Role;Seizures;small molecule;solute;Specificity;Structure;Synapses;synaptic function;Synaptic Transmission;Synaptic Vesicles;Therapeutic Intervention;therapeutically effective;Time;Variant;Vesicle;Work

PROJECT_TITLE: Structural and functional investigations on synaptic vesicular transporters

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE The proposed work is relevant to NIH’s mission statement because it seeks to dissect the precise mechanisms by which RNA editing enzyme ADAR1 regulates gene expression and contributes to malignant T-cell leukemia initiating cell propagation. Thus, it will fundamentally advance our mechanistic understanding of the molecular mechanisms contributing to LIC-driven malignancies. In addition, it will prove ADAR1, an oncogenic RNA deaminase, as a novel target that warrants future therapeutic development.

PI_NAMEs: JIANG, QINGFEI  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Acute T Cell Leukemia;Adenosine;Apoptosis;Bypass;cancer cell;cancer stem cell;Cell Maintenance;Cell Physiology;Cell Survival;cell type;Cells;Child;Childhood Precursor T Lymphoblastic Leukemia;Clinical;Coculture Techniques;conventional therapy;curative treatments;Data;Deaminase;Development;Double-Stranded RNA;dsRNA adenosine deaminase;Ectopic Expression;effective therapy;Enzymes;Exhibits;experimental study;Future;Gene Expression;Genes;Genetic Transcription;Goals;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Human;Impairment;improved;Inflammation;inhibitor;Innate Immune Response;Inosine;Interferon Activation;Interferons;knock-down;Knock-out;leukemia initiating cell;leukemic stem cell;Ligands;Link;Maintenance;Malignant - descriptor;Malignant Neoplasms;Maps;Mediating;Medical;Mission;Molecular;mouse model;Mutation;notch protein;NOTCH1 gene;novel;novel therapeutics;Nuclear;Oncogenic;Organoids;Outcome;patient derived xenograft model;Patients;Play;Population;prevent;programs;Protein Isoforms;Refractory;Relapse;Resistance;RNA;RNA Binding;RNA Editing;Role;secretase;self-renewal;sensor;Series;Signal Induction;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Stress;Survival Rate;System;T-Cell Leukemia;Testing;therapeutic development;therapy resistant;Thymus Gland;United States National Institutes of Health;Work

PROJECT_TITLE: Elucidate the Role of RNA Editing in Acute T-cell Lymphoblastic Leukemia Initiating Cells

STUDY_SECTION: BCO

STUDY_SECTION_NAME: Biochemical and Cellular Oncogenesis Study Section[BCO]


ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE: The goal of this research study is to examine the biology and efficacy of Siglec-6 in reducing or preventing mast cell activation via several distinct stimulatory pathways and delivering therapeutic cargo selectively to mast cells both in vitro and in several mouse models of mast cell-dependent diseases, incorporating transgenic mice expressing the human Siglec-6 receptor and humanized mice bearing a human mast cell line. Siglec-6, as a receptor found at high levels on human mast cells in the skin, lung, adipose tissue, and colon and on all mast cell lines that we have analyzed and on few other hematopoietic cells, offers critical advantages over the related receptor Siglec-8, which we have studied as a target on eosinophils and mast cells, but which is not as selectively or consistently expressed on mast cells and is not as effective in inhibiting mast cell activation. Knowledge of the signaling and endocytic pathways of the receptor, as well as the efficacy of distinct approaches to mast cell targeting in vitro and in vivo, would provide important insights into potential treatments of diseases and conditions involving mast cells, such as anaphylaxis, pseudoallergic drug reactions, mast cell-dependent cutaneous inflammation, and systemic mastocytosis, for which there is a clinical need for disease-modifying or curative therapeutic approaches.

PI_NAMEs: O'SULLIVAN, JEREMY A (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Adipose tissue;Adverse event;Allergic;Anaphylaxis;Antibodies;Arginine;Attention;B-Lymphocytes;Basophils;Binding;Biology;Biotinylation;CD34 gene;CD8-Positive T-Lymphocytes;Cell Compartmentation;Cell Count;Cell Line;cell type;Cells;Charge;Chronic;Clinical;clinical development;Collaborations;Colon;Complex;crosslink;curative treatments;Cutaneous;cytokine;Cytoplasm;Cytoplasmic Tail;Data;Dedications;Disease;efficacy evaluation;Endocytosis;Engineering;eosinophil;exhaust;Exhibits;experimental study;Family;functional outcomes;Goals;Hematopoietic;Hematopoietic stem cells;Human;humanized mouse;Hypersensitivity;IgE Receptors;Immunocompromised Host;Immunoglobulins;Immunology;In Vitro;in vivo;in vivo imaging;Inflammation;insight;Interstitial Cell of Cajal;ITIM;Knowledge;Lead;Lectin;Ligands;Ligation;Link;Liposomes;Luciferases;Lung;Malignant - descriptor;mast cell;Mast-Cell Leukemia;Mediating;Mediator;Megakaryocytes;melanocyte;member;Minor;Modeling;Modification;Molecular Target;Monoclonal Antibodies;mouse model;Mus;mutant;novel;Orthologous Gene;Passive Cutaneous Anaphylaxis;Pathway interactions;Pharmaceutical Preparations;Pharmacology;Phosphoric Monoester Hydrolases;placental trophoblasts;Polysaccharides;Population;Pregnancy;prevent;Proliferating;promoter;Property;prophylactic;Protein Tyrosine Phosphatase;PTPN6 gene;Reaction;receptor;receptor expression;recruit;reduce symptoms;research study;response;selective expression;sialic acid binding Ig-like lectin;Sialic Acids;Signal Pathway;Signal Transduction;Signaling Protein;Skin;Spermatogonia;Stimulus;Streptavidin;sugar;Systemic Mastocytosis;targeted agent;Taste Perception;Testing;Therapeutic;therapeutic target;tool;Transfection;Transgenic Mice;Transgenic Organisms;Up-Regulation;Urticaria

PROJECT_TITLE: Modulation and exploitation of Siglec-6 function to broadly impede mast cell activation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-F (57)]


ADMINISTERING_IC: GM

ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: SAN ANTONIO

ORG_NAME: ST. MARY'S UNIVERSITY

PHR: Project Narrative St. Mary’s University is a Hispanic-serving institution in San Antonio, TX that serves students primarily from South Texas. Despite being a resource-limited institution receiving well under $6 million in research funding from the National Institutes of Health, it has a strong record of developing the biomedical workforce and preparing graduates for STEM and health careers. Access to a state-of- the-art scientific flow cytometry instrument that can assess cells or particles for wide range of characteristics, will invigorate current research at St. Mary’s; contribute to opportunities for new research projects; stimulate collaborations; attract, recruit, and retain new faculty to St. Mary’s; develop critical thinking and technical skills in students; and enhance STEM education.

PI_NAMEs: CONTRERAS-SHANNON, VERONICA E (contact)

PROGRAM_OFFICER_NAME: BECKETT, DOROTHY

PROJECT_TERMS: Biochemistry;Biological Sciences;Biology;Biomedical Research;Cardiovascular Diseases;Cell Count;Cell Cycle Stage;Cells;clinical diagnostics;Development;Discipline;Education;Education Projects;Enrollment;Faculty;Flow Cytometry;Fostering;Future;Future Teacher;Genetic Diseases;Goals;Immunology;improved;Infection;Institution;instrument;instrumentation;interest;Laboratories;Malignant Neoplasms;Microbiology;Minor;Modification;particle;Productivity;protein expression;recruit;Research;Research Project Grants;Science, Technology, Engineering and Mathematics Education;Students;Techniques;Technology;Toxicology;Training;undergraduate research experience;undergraduate student;Universities

PROJECT_TITLE: Research Flow Cytometer for Research and Education Capacity Building at St. Mary's University

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-L (30)]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Obsessive-compulsive disorder (OCD) is common, chronic and often difficult to treat disorder that results in prolonged and disabling effects in an estimated 2-3% of the general population, during their lifetime. It manifests in a variety of compulsions and obsessions but the neural mechanisms underlying the disorder or its differentiations remain unclear. In this project, we leverage model-based analysis of behavior and fMRI activity, jointly with brain network analysis, with the aim to provide a more comprehensive understanding of brain dynamics underlying OCD symptom severity and phenotypization.

PI_NAMEs: FIGEE, MARTIJN ;FIORE, VINCENZO GUIDO (contact)

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Affect;Algorithmic Analysis;Basal Ganglia;Bayesian Analysis;Behavior;Behavioral;Brain;Categories;causal model;Choice Behavior;Chronic;compulsion;Computer Analysis;Computer Models;Corpus striatum structure;Data;Decision Making;Deep Brain Stimulation;Dependence;Development;Disabling;Disease;Disputes;Dorsal;Environment;Equilibrium;Exhibits;flexibility;Fostering;Functional Imaging;Functional Magnetic Resonance Imaging;General Population;Goals;Heterogeneity;innovation;interest;Kinetics;Lateral;Learning;learning algorithm;Link;Literature;maladaptive behavior;Measures;Mental disorders;Modeling;Motor;Motor Cortex;Network-based;neural;neuromechanism;neuroregulation;novel;Obsession;Obsessive-Compulsive Disorder;Outcome;Participant;Pathway Analysis;Pathway interactions;Patients;Phenotype;Play;Policies;Population;precision neuromodulation;Prefrontal Cortex;Prevalence;Psychological reinforcement;Publishing;putamen;recruit;Residual state;reward processing;Rewards;Running;Severities;symptomatology;Symptoms;Testing;theories;Thinking;tool;Transcranial magnetic stimulation;treatment response;ultra high resolution;Update;Ventral Striatum;Weight

PROJECT_TITLE: Neurocomputational mechanisms and connectivity dynamics underlying obsessive-compulsive disorder and phenotypical differentiations

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Asthma;Clinical Research;Genetics;Infectious Diseases;Lung;Precision Medicine;Prevention

PHR: PROJECT NARRATIVE Exposure to viral and bacterial infections represents a leading risk factor in asthma exacerbations, but individual variability in response, and the role of multi-omics in this response, is not well-understood, particularly across the life course. Characterization of virulent exposures through PhIP-Seq profiling in well-characterized child and adult asthma cohorts with existing genetic, epigenetic, and metabolomic data provides an ideal opportunity to leverage novel integrative omic methods, specifically cooperative learning, to increase our understanding of the impact of these virulent exposures, their interactions with individual biology reflected by multi-omics, and their consequences for asthma exacerbations. We apply PhIP-Seq in existing cohorts with minimal cost to this proposal, identify virulent and multi-omic factors with the highest contributions to asthma exacerbations, and develop universal and personalized predictive models to understand the interplay between these factors and to assess risk with respect to individual variability.

PI_NAMEs: LASKY-SU, JESSICA A (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: Active Learning;Adult;Adult asthma;Affect;Age;airway remodeling;Antibodies;Antibody Response;Asthma;asthma exacerbation;Bacteria;Bacterial Antibodies;Bacterial Infections;biobank;Biological;Biology;Child;Childhood Asthma;cohort;Complex;cost;cost effective;Costa Rica;Coupled;Data;data integration;Development;Disease;Economic Burden;Emergency department visit;Environmental Exposure;Epigenetic Process;Ethnic Origin;Evaluation;Exposure to;Genetic;Hospitalization;Immune response;Individual;individual variation;individualized prevention;Life;Life Cycle Stages;Link;Linoleic Acids;Measures;metabolomics;Methodology;Methods;Microbe;Morbidity - disease rate;Multiomic Data;multiple omics;multiplex detection;novel;novel strategies;Outpatients;Pathway interactions;personalized predictions;personalized therapeutic;Phage ImmunoPrecipitation Sequencing;Plasma;Play;precision medicine;predictive modeling;Predisposition;programs;pulmonary function;Race;racial difference;response;Rhinovirus;Risk Assessment;Risk Factors;Role;Sampling;Severities;Severity of illness;sex;sex as a biological variable;Sphingolipids;Stimulus;targeted treatment;Technology;Testing;therapeutic target;Time;United States;Variant;Viral;Viral Antibodies;Virulent;Virus;Virus Diseases;Visit

PROJECT_TITLE: Better utilization of omics data to inform precision medicine for asthma throughout the life course

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: CAYEY

ORG_NAME: UNIVERSITY OF PR CAYEY UNIVERSITY COLL

ORG_STATE: PR

PHR: Project Narrative: The acquisition of the XploRA PLUS Raman Microscope (XP RM) at the University of Puerto Rico at Cayey (UPR-C) is highly relevant to public health as it enables advanced research in biomedical sciences, such as the characterization of polymer scaffolds for biomedical applications, studying lipid dendrimers for drug delivery, and solid electrolyte performance of medical device batteries. The instrument's impact on research and education at UPR-C is significant, empowering underrepresented students, promoting diversity, and fostering scientific engagement through projects that utilize the XP RM in courses, laboratories, and biomedical research.

PI_NAMEs: BARRIONUEVO, DANILO  (contact)

PROJECT_TERMS: advanced analytics;Area;Biological Sciences;Biology;Biomedical Research;Biosensor;Chemistry;Communities;Data;Dendrimers;design;Detection;Development;Drug Delivery Systems;early-career faculty;Education;Educational Activities;Electrolytes;empowerment;Ensure;Fostering;Funding;Gases;Grant;Hispanic;hispanic community;Institution;instrument;interest;Knowledge;Laboratories;Learning;Lipids;Maps;Medical Device;Medicine;member;Methods;Microscope;Minority;Monitor;Motivation;Natural Sciences;Performance;Pharmacologic Substance;Physics;Polymers;Positioning Attribute;Postdoctoral Fellow;Puerto Rico;Research;Research Activity;Research Project Grants;Resolution;S10 grant;Sampling;scaffold;Scientific Advances and Accomplishments;Scientist;Secure;senior faculty;sensor;skills;Solid;student participation;Students;System;Techniques;Training;undergraduate student;United States National Institutes of Health;Universities;Visualization;Work

PROJECT_TITLE: Confocal Raman Microscope Acquisition


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Genetics;Hematology;Hodgkin's Disease;Human Genome;Lymphatic Research;Lymphoma;Neuroblastoma;Neurosciences;Pediatric;Pediatric Cancer;Precision Medicine;Prevention;Rare Diseases

PHR: PROJECT NARRATIVE Despite advances in pediatric oncology treatment and research, our understanding of the genetic etiology of pediatric cancers remains incomplete. We propose to undertake a first-of-its-kind analysis of pediatric cancer pleiotropy, identifying genetic variations that contribute to risks for multiple pediatric cancer types. We will also examine the shared heritability of pediatric cancers with the first comprehensive study of global pleiotropy patterns for pediatric cancer risk, and develop enhanced genetic risk score tools with pleiotropic risk variants to better predict who may develop pediatric cancer and inform personalized treatment, surveillance, and interventions to reduce morbidity and mortality after pediatric cancer diagnosis.

PI_NAMEs: IM, CINDY ;WANG, ZHAOMING  (contact)

PROGRAM_OFFICER_NAME: DAEE, DANIELLE L

PROJECT_TERMS: Acute Lymphocytic Leukemia;Adult;adverse outcome;Age of Onset;age stratification;Algorithms;Alleles;ancestry analysis;Architecture;Biological;BRCA2 gene;cancer diagnosis;Cancer Etiology;cancer genetics;cancer genome;cancer predisposition;cancer risk;cancer subtypes;Cancer Survivor;cancer type;carcinogenicity;Cause of Death;Characteristics;chemotherapy;Child;Childhood Acute Lymphocytic Leukemia;Childhood Cancer Genome Project;childhood cancer survivor;Childhood Cancer Survivor Study;Childhood Hodgkin's Lymphoma;Childhood Non-Hodgkin's Lymphoma;Clinical;Cohort Studies;cost effective;Data;data harmonization;Data Pooling;data resource;Data Set;design;Development;Disease;effective therapy;ETV6 gene;Evaluation;Ewings sarcoma;exome sequencing;experience;Face;Funding;GATA3 gene;Generations;Genes;Genetic;Genetic Enhancement;Genetic Predisposition to Disease;Genetic Risk;Genetic study;Genetic Variation;Genome;genome resource;genome wide association study;genome-wide;genomic data;genomic locus;Genomics;Goals;Health;Heritability;Hodgkin Disease;improved;Individual;Inherited;innovation;insight;Intervention;Investigation;Knowledge;knowledge base;Lead;Link;Literature;Long-Term Survivors;Malignant Childhood Neoplasm;Malignant Neoplasms;Maps;Medulloblastoma;Methods;Morbidity - disease rate;mortality;Nephroblastoma;Neuroblastoma;Newly Diagnosed;Non-Hodgkin's Lymphoma;novel;Osteosarcoma;Outcome;Pattern;Pediatric Neoplasm;Pediatric Oncology;Pediatric Research;personalized medicine;pleiotropism;polygenic risk score;power analysis;precision medicine;Process;programs;rare cancer;rare variant;Relapse;Research;Resources;Risk;risk prediction;risk variant;Saint Jude Children's Research Hospital;Sarcoma;Solid Neoplasm;Survival Rate;Survivors;survivorship;Susceptibility Gene;Therapeutic;Time;tool;United States National Institutes of Health;Variant;whole genome;Work

PROJECT_TITLE: Genetic pleiotropy across pediatric cancers, and cancer-related outcomes

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Chronic Pain;Clinical Research;Heart Disease;Hypertension;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: SALT LAKE CITY

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Relevance to Public Health  This research in humans will investigate the consequences of chronic neuropathic pain on the cardiovascular health of this ever-growing patient population. We will study mechanisms possibly mediating this impact and the potential of a currently utilized treatment option for neuropathic pain (i.e., spinal cord stimulation, SCS) to improve the cardiovascular health in these patients, particularly in those with high blood pressure (hypertension). If this project can, as suggested by our preliminary findings, confirm a significant impact of chronic pain on the cardiovascular system and that SCS can improve these impairments, particularly in patients with with hypertension, the proposed studies will provide the scientific basis required to associate SCS with significant cardiovascular health benefits.

PI_NAMEs: AMANN, MARKUS  (contact);WRAY, D. WALTER

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: Activities of Daily Living;Affect;arm;Attenuated;attenuation;Back;Baroreflex;Blood flow;Blood Pressure;blood pressure reduction;Brain;Buffers;Cardiac;Cardiovascular Abnormalities;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular Physiology;Cardiovascular system;Cervical spine;Characteristics;chronic neuropathic pain;chronic pain;chronic pain management;chronic pain patient;Circulation;Clinical;comparison control;cost;Data;Development;Diabetes Mellitus;Disease;efficacy evaluation;Electric Stimulation;Event;Exercise;exercise program;Fatigue;Feedback;Fentanyl;Goals;Health;Health Benefit;Heart Diseases;hemodynamics;high risk;Human;Hypertension;hypertensive;Impairment;improved;Individual;innovation;Leg;Lower Extremity;Malignant Neoplasms;Mediating;Methods;mortality;Muscle;Neck;Nerve;neuromuscular;neuroregulation;Neurostimulation procedures of spinal cord tissue;neurovascular;Nociception;normotensive;Pain management;painful neuropathy;Patient Care;patient population;Patients;peroneal nerve;Physical activity;Physiological;Population;pressure;Productivity;Psyche structure;psychosocial;public health research;Quality of life;Reflex action;Resistance;response;Rest;Risk;Role;sensory feedback;Sensory Nerve Endings;Spinal Ganglia;Stroke;Structure of radial nerve;Suction;Sympathetic Nervous System;Techniques;Therapeutic;Vascular resistance

PROJECT_TITLE: Cardiovascular and neuromuscular issues in chronic pain

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Aging;Cystic Fibrosis;Digestive Diseases;Lung;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE This study will address a major health issue of chronic constipation in cystic fibrosis patients and geriatric population which affects the health and well-being of large populations. The research will help us understand the underlying mechanism of how the impairment in intestinal fluid secretion and homeostasis contributes to chronic constipation. In this study, we will use clinically relevant samples from patients which warrants a high translational potential of our findings to the clinical management of the disease and will help develop new therapeutics.

PI_NAMEs: NAREN, ANJAPARAVANDA P (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Address;Adopted;Affect;Aging;Apical;Applications Grants;Back;bench to bedside;Biological Process;Cells;Chronic;Clinical;Clinical Management;clinically relevant;Complex;Constipation;Cyclic AMP;Cyclic GMP;Cystic Fibrosis;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Defect;design;Development;Diarrhea;Disease;Disease Management;disease phenotype;Distal;Elderly;Epithelial Cells;experience;FDA approved;Fluid Balance;Fluids and Secretions;Functional disorder;gastrointestinal;Gastrointestinal Diseases;gastrointestinal epithelium;gastrointestinal system;General Population;Grant;gut health;Health;Ileus;Impairment;improved;inhibitor;innovation;insight;Intervention;intestinal epithelium;Intestinal Fibrosis;Intestinal Obstruction;Intestines;Life;Life Expectancy;Link;Macromolecular Complexes;Meconium;Mediating;Mediator;Molecular;mouse model;mutant;Mutation;Newborn Infant;novel;novel therapeutics;old mice;Pathogenesis;Pathogenicity;patient response;Patient-Focused Outcomes;Patients;Personal Satisfaction;personalized medicine;Play;Population;Process;Protein Isoforms;Research;Research Personnel;Role;Sampling;Scaffolding Protein;Side;Signal Pathway;Signal Transduction;single-cell RNA sequencing;sodium-hydrogen exchanger regulatory factor;stem cells;Study models;Technology;Testing;therapeutic target;Translating;translational potential

PROJECT_TITLE: Inhibition of an Apical cAMP/cGMP Transporter (MRP4) in the Gut Induces Diarrhea

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


NIH_SPENDING_CATS: Genetics

ORG_CITY: MINNEAPOLIS

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Narrative PUBLIC HEALTH RELEVANCE: Revealing the mechanisms that promote faithful genome transmission in mitosis is important for determining the molecular basis of birth defects and human cancers caused by genomic instability. Understanding this new mitotic control mechanism will provide insight into how cells ensure Topo II activity is sufficient to permit efficient chromatid separation, and therefore avoid aneuploidy.

PI_NAMEs: CLARKE, DUNCAN J. (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Anaphase;Aneuploidy;Area;aurora B kinase;Binding;Biochemical;C-terminal;Cancer Etiology;cancer therapy;Catenated DNA;Cell Cycle;Cell Cycle Regulation;Cell division;Cells;Centromere;Chromatids;Chromatin;Chromosome Segregation;Chromosomes;Closure by clamp;Complex;Congenital Abnormality;Data;daughter cell;Development;developmental disease;Dissection;DNA;Drug Targeting;Ensure;Enzymes;Event;Failure;Feeds;Functional disorder;Genome;Genomic Instability;Haspin;Human;Human Engineering;insight;Kinetochores;Lead;Malignant Neoplasms;Mechanics;Methylation;Microtubules;Mitosis;Mitotic;Mitotic Spindle Apparatus;Molecular;Molecular Conformation;molecular modeling;Monitor;Nucleosomes;Outcome Study;Pathway interactions;Phase;Phosphotransferases;Positioning Attribute;Process;public health relevance;Reaction;recruit;Regulation;repaired;response;Role;scaffold;segregation;Signal Transduction;Sister Chromatid;Site;Sumoylation Pathway;System;Testing;Therapeutic;therapeutic target;tool;Topoisomerase II;Topoisomerase II inhibition;translational potential;Translational Research;translocase;transmission process;TRAP Complex;treatment strategy;ubiquitin-protein ligase;Yeasts

PROJECT_TITLE: Control of Chromosome Segregation by DNA Topoisomerase II

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]