NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

PI_NAMEs: KONIECZNY, STEPHEN F (contact)

PROJECT_TERMS: Ablation;Anatomy;Animal Model;Animals;anti-cancer research;Area;assisted reproduction;Biological Models;blastocyst;Breeding;Cancer Biology;cancer cell;Cancer Center Support Grant;Cancer Model;cancer stem cell;cancer therapy;carcinogenesis;Categories;Cell Communication;Cell Cycle Regulation;Cell Lineage;Cells;Cellular biology;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Complex;cost effective;CRISPR/Cas technology;Derivation procedure;Development;DNA;DNA Sequence;embryo cryopreservation;Embryo Transfer;embryonic stem cell;Fertilization in Vitro;Funding;Future;Gene Expression Profile;Gene Modified;gene replacement;Gene Targeting;Genes;Genetic;Genetic Engineering;Genetic Transcription;Genetically Engineered Mouse;Genome;genome editing;Germ Lines;Growth;human disease;Immune;improved;Infiltration;Injections;Intervention;Knock-in;Knock-out;Maintenance;Malignant Neoplasms;Mediating;member;Modeling;Molecular;mouse genome;Mus;NCI Center for Cancer Research;Neoplasm Metastasis;novel;novel therapeutic intervention;Oncology;Pathway interactions;Patient Care;Peer Review;Physiological;preservation;Proto-Oncogenes;rat genome;Rattus;Reagent;Regulation;Regulatory Pathway;Research Personnel;Resistance;Resource Sharing;Resources;Rodent;Services;Signal Transduction;Signal Transduction Pathway;sperm cryopreservation;success;Technology;Testing;Therapeutic;tool;Transgenic Animals;Transgenic Organisms;tumor initiation;tumor progression;Tumor Promotion;Tumor Suppressor Genes;Universities;Xenograft Model

PROJECT_TITLE: Transgenic and Genome Editing Facility (TGEF-SR)


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: WEST LAFAYETTE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PI_NAMEs: HUTCHCROFT, JILL E (contact)

PROJECT_TERMS: analytical tool;anti-cancer research;Automobile Driving;Biological Sciences;Calibration;Cancer Center;Cancer Center Support Grant;Cancer Diagnostics;Cell Separation;Cells;Characteristics;Chromium;Client;Color;Complement;Computer software;cost effective;Cytometry;Data;Data Analyses;design;Development;Equipment;experience;experimental study;flexibility;Flow Cytometry;Flow Cytometry Shared Resource;Funding;Genome;Grant;Human;Human Resources;improved;instrument;instrumentation;Lasers;Licensing;Malignant Neoplasms;Measures;member;Modernization;Mus;NCI Center for Cancer Research;Optics;Organelles;particle;Peer Review;Postdoctoral Fellow;Property;Publications;research faculty;Research Personnel;Research Project Grants;Research Training;Resource Sharing;Resources;Schedule;Services;single cell genomics;Site;Sorting;Speed;Students;System;Technical Expertise;Technology;Therapeutic;tool;Training;transcriptome;United States National Institutes of Health;Universities

PROJECT_TITLE: Flow Cytometry (FC-SR)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


PI_NAMEs: LANMAN, NADIA ATALLAH (contact)

PROJECT_TERMS: analysis pipeline;Applications Grants;Attention;Bioinformatics;Bioinformatics Shared Resource;Biological;Biological Sciences;Cancer Center Support Grant;ChIP-seq;Computer software;computing resources;Consultations;cost effective;CRISPR/Cas technology;Data;data acquisition;Data Analyses;design;Discipline;Educational process of instructing;Educational workshop;Ensure;epigenomics;Experimental Designs;experimental study;Faculty;Funding;genome sequencing;Genomics;Genomics Shared Resource;graduate student;Grant;Guidelines;High Performance Computing;High-Throughput Nucleotide Sequencing;improved;Individual;interest;Journals;laboratory experience;Learning;Life;Linux;Literature;Manuscripts;member;Mentors;Methodology;NCI Center for Cancer Research;novel;Peer Review;Postdoctoral Fellow;programs;Protocols documentation;Publications;Publishing;Purdue Cancer Center;Reporting;Research;research faculty;Research Personnel;Research Project Grants;Resources;Scientist;Services;single cell sequencing;single-cell RNA sequencing;skills;student training;Students;Technology;Time;Training;training opportunity;transcriptomics;undergraduate student;whole genome;Work;Writing

PROJECT_TITLE: Computational Genomics (CG-SR)


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Regenerative Medicine

ORG_CITY: BOSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Epithelial cells in barrier tissues sustain frequent damage from a variety of external insults. The role of macrophages in regulating inflammatory responses and promoting epithelial repair following damage is poorly understood. The proposed work will elucidate novel mechanisms underlying macrophage-mediated regulation of inflammation and tissue repair.

PI_NAMEs: FRANKLIN, RUTH A (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Biological;Cell Communication;Cell Physiology;cell type;Cells;Chemicals;Communication;Complex;Development;Disease;Environment;Epithelial Cells;epithelial repair;Epithelium;epithelium regeneration;Goals;Homeostasis;Immune;Immunologic Surveillance;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;Injury;insight;interdisciplinary approach;interest;Knowledge;Laboratories;Macrophage;Mediating;Modeling;Mucous Membrane;Natural Immunity;novel;novel therapeutic intervention;Organoids;pathogen;Pathologic;Play;Population;programs;Regenerative Medicine;Regulation;repaired;reparative capacity;Research;response;Role;Site;Source;stem;stem cell population;System;tissue repair;Tissues;Viral;Work

PROJECT_TITLE: Macrophage-mediated regulation of inflammation and tissue repair

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: ELZEY, BENNETT DAVID (contact)

PROJECT_TERMS: Adopted;Amendment;Animal Cancer Model;Animal Experiments;Animal Model;animal model development;animal model selection;Animals;anti-cancer research;Antineoplastic Agents;Applications Grants;Area;Autopsy;Basic Science;Behavior;Biological;Biology;Bladder;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cancer Model;cancer type;Canis familiaris;Cell Line;Characteristics;Chemistry;Clinical Trials;Collaborations;combat;Consultations;cost;cost effective;Data;design;Development;Diagnosis;Discipline;Disease;drug development;Drug Kinetics;efficacy study;Engineering;Environment;Evaluation;experimental study;Extramural Activities;Familiarity;Family;Flow Cytometry Shared Resource;Foundations;Funding;Future;Human;Human Cell Line;Immunocompromised Host;Implant;In Vitro;in vivo;in vivo evaluation;Malignant - descriptor;Malignant Neoplasms;Measures;member;Methods;Mission;Modeling;Molecular;mouse model;Mus;NCI Center for Cancer Research;Neoplasm Metastasis;New Agents;new technology;novel strategies;novel therapeutics;Nutritional Science;Outcome;Pathway interactions;patient derived xenograft model;Peer Review;Pharmacologic Substance;Play;Preclinical Testing;prevent;Procedures;Process;Productivity;prostate cancer model;Protocols documentation;Publications;Purdue Cancer Center;Quality Control;Regulation;Reproducibility;Reproducibility of Results;Research;Research Personnel;Research Support;Resource Sharing;Role;Safety;Science;Services;small cell lung carcinoma;Standardization;statistics;Structure;Technology;Testing;text searching;The Jackson Laboratory;Tissues;tool;Toxic effect;Toxicity Tests;Toxicology;Training;Transgenic Animals;translational study;Transplantation;treatment response;tumor;Tumor Cell Invasion;tumor growth;tumorigenesis;Universities;Validation;validation studies;Veterinary Medicine;Veterinary Schools;War;Xenograft procedure

PROJECT_TITLE: Biological Evaluation SR (BE-SR)


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer

PI_NAMEs: MESECAR, ANDREW D (contact)

PROJECT_TERMS: Address;anti-cancer research;Area;Awareness;Biological Sciences;Biopolymers;Cancer Center Support Grant;Categories;Communities;comparative;Complex;Coupled;Development;Dissociation;Electron Transport;Electrospray Ionization;Electrostatics;experience;Explosion;Fourier Transform;Future;Image;improved;instrumentation;ion mobility;ionization technique;Ions;Lipids;Liquid Chromatography;Malignant Neoplasms;mass spectrometer;mass spectrometry shared resource;Mass Spectrum Analysis;Measurement;Measures;member;metabolomics;Methodology;Molecular Analysis;molecular mass;Molecular Weight;Nature;NCI Center for Cancer Research;novel;Nucleic Acids;Organelles;Organic Synthesis;Pharmaceutical Preparations;Play;Post-Translational Protein Processing;protein complex;protein protein interaction;Proteins;Proteomics;Purdue Cancer Center;Research;Research Personnel;Resource Sharing;Science;Services;small molecule;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;tandem mass spectrometry;Technology;technology development;time of flight mass spectrometry;tool;Trace Elements

PROJECT_TITLE: Life Sciences Mass Spectrometry Facility (LSMSF-SR)


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Cancer;Clinical Research;Colorectal Cancer;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Digestive Diseases;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Not enough people receive the cancer screenings (such as colonoscopies and mammograms) that they need, and COVID-19 has made getting these services more difficult. Our study will examine the impacts of COVID-19 on cancer screening and follow-up care for low-income and Latinx adults served by community health centers. Our goal is to guide community health centers in recovering from COVID- 19, ensure more equitable access to cancer screening, and save lives from preventable cancers.

PI_NAMEs: DICKERSON, JOHN F (contact)

PROGRAM_OFFICER_NAME: WEAVER, SALLIE JAYNE

PROJECT_TERMS: Adult;American Cancer Society;authority;cancer diagnosis;cancer health disparity;Cancer Intervention and Surveillance Modeling Network;cancer prevention;care delivery;Caring;Centers for Population Health;Cessation of life;Clinic;Clinical;Collaborations;Colonoscopy;Colorectal Cancer;Communities;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Sources;Disparity;disparity reduction;Drops;economic impact;Electronic Health Record;Eligibility Determination;Ensure;Equity;Ethnic Origin;experience;federal poverty level;Federally Qualified Health Center;follow-up;Fright;Future;Gastroenterology;Goals;health assessment;health disparity populations;Health Services;Health Services Accessibility;Health system;Hospitalization;improved;Incidence;Income;Individual;infection rate;innovation;Insurance Coverage;Interruption;Intervention;Interview;Job loss;Language;Latinx;Latinx population;Life;long term consequences of COVID-19;long term COVID-19 pandemic impacts;Long-Term Care;Long-Term Effects;Low income;Malignant Neoplasms;Mammography;Medical;medical specialties;Methods;Modeling;models and simulation;Natural Disasters;Neighborhood Health Center;Outcome;pandemic disease;pandemic impact;Pap smear;patient-level barriers;Patients;Pattern;Persons;post-COVID-19;post-pandemic;pre-pandemic;preference;prevent;Preventive care;Primary Care;Protocols documentation;Provider;Race;Recommendation;Recovery;Recovery Support;Reduce health disparities;Research;Resources;SARS-CoV-2 infection;screening;Screening for cancer;screening services;service delivery;Services;sex;Site;telehealth;trend;United States;uptake;Visit;Vulnerable Populations

PROJECT_TITLE: Assessing the long-term impacts of the COVID-19 pandemic on disparities in cancer screening and follow-up

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Rare Diseases

PI_NAMEs: ANDRISANI, OURANIA M. (contact)

PROJECT_TERMS: Acceleration;Address;Animal Cancer Model;Arabidopsis;Award;Bioinformatics;Biological Models;biomarker development;Biometry;cancer cell;Cancer Cell Growth;Cancer Center Support Grant;cancer genomics;Cancer Model;cancer recurrence;Cancer Research Project;cancer stem cell;Cell Culture Techniques;cell growth;cell growth regulation;Cell Physiology;Cells;Cellular biology;college;Computational Biology;Development;Drosophila genus;Drug Delivery Systems;Drug Design;drug discovery;Drug resistance;Embryonic Development;Epigenetic Process;Extramural Activities;Fostering;Funding;Future;Gene Expression;Genes;Genetic;Genomics;Goals;Grant;Immunity;Institution;inter-institutional;Journals;Knowledge;Laboratories;Laboratory Research;Link;liposarcoma;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;member;Metabolic;Mission;model organism;Modeling;Modernization;Molecular;mouse model;Nature;NCI Center for Cancer Research;Neoplasm Metastasis;novel;nutrition;Paper;Pathogenesis;Pathway interactions;Peer Review;prevent;Process;Productivity;Program Research Project Grants;programs;Publications;Publishing;Purdue Cancer Center;Research;Research Personnel;Research Support;Resource Sharing;Scientific Advances and Accomplishments;Signal Transduction;Strategic Planning;structural biology;targeted treatment;Technology;therapeutic development;therapy resistant;tool;Training;transcriptomics;Tumor Immunity;Validation;Yeasts;Zebrafish

PROJECT_TITLE: Cell Identity and Signaling (CIS)


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Biotechnology;Chronic Obstructive Pulmonary Disease;Clinical Research;Genetics;Lung

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative/Public Health Relevance Chronic Obstructive Pulmonary Disease is a major cause of morbidity worldwide and the 3rd leading cause of death in the United States. There are no cures for this disease and the standard forms of treatment often do not provide adequate relief, as much of the morbidity and mortality is due to mucus obstruction of the airways. There are currently no specific and effective therapies available for excess mucus production. The proposed work aims to identify new ways to treat this disorder by investigating the source of inflammation and mucus overproduction in the airways, thereby addressing a previously unmet need for treatment of a major public health problem.

PI_NAMEs: ALEXANDER-BRETT, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: Acute;Address;Affinity;Airway Disease;airway epithelium;airway obstruction;Allergens;Alternaria;Animal Model;Asthma;asthma exacerbation;Automobile Driving;Binding;Biological Assay;Biology;Bronchoalveolar Lavage;Bypass;Cause of Death;Cell model;Cell Nucleus;Cell secretion;Cells;Chronic;Chronic Bronchitis;Chronic Disease;Chronic Obstructive Pulmonary Disease;chronic respiratory disease;Clinical Research;Complex;Coupled;cytokine;Cytoplasm;Data;Development;Diagnosis;Disease;disease model;disease phenotype;effective therapy;Endosomes;Enzyme-Linked Immunosorbent Assay;Epithelial Cells;epithelial stem cell;Epithelium;Exhibits;Exons;exosome;Foundations;genome wide association study;Heat-Shock Proteins 70;Human;IL8 gene;In Vitro;in vivo;Inflammation;insight;Interferometry;knock-down;Knowledge;Length;Liquid substance;live cell imaging;Lower respiratory tract structure;Mass Spectrum Analysis;Measures;Mediating;Mediator;Messenger RNA;Metaplasia;mimetics;Molecular;Molecular Chaperones;Morbidity - disease rate;mortality;mouse model;Mucous body substance;Mucous Membrane;Mus;mutant;Necrosis;novel;novel strategies;Nuclear;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Peptide Signal Sequences;Phosphorylation;Play;Post-Translational Protein Processing;Process;Production;protein expression;Protein Isoforms;Protein Secretion;Proteins;Proteomics;Public Health;public health relevance;Pulmonary Emphysema;Reagent;receptor;Receptor Activation;receptor binding;Receptor Signaling;recruit;Research;Respiratory Tract Diseases;RNA Splicing;Role;Signal Transduction;Smoke;Source;Specimen;Sphingomyelinase;Structure;Structure of parenchyma of lung;System;Testing;Therapeutic Intervention;trafficking;translational study;United States;Validation;Viral;Virus;Western Blotting;Work;X-Ray Crystallography

PROJECT_TITLE: Non-Classical Cytokine Secretion in Chronic Airway Disease

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Autism;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Project Narrative In order to develop more effective treatments for autism spectrum disorder (ASD), there is a strong need for biomarkers that can help to target treatments to subgroups most likely to benefit from specific treatments, and that can also help in monitoring treatment response. Such biomarkers are especially needed for autistic adults, because there are more than 5 million American adults on the autism spectrum who have received less research attention than children, and because our preliminary data suggest potential brain electrophysiology biomarkers indeed exist in adults. In this project, we will assess several promising brain electrophysiological markers for their suitability and readiness to be used in clinical trials in autistic adults.

PI_NAMEs: BRODKIN, EDWARD S;ROBERTS, TIMOTHY P (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: Address;Adolescence;Adolescent;adolescent with autism spectrum disorder;Adult;adult with autism spectrum disorder;Age;American;analog;Anxiety;Anxiety Disorders;Attention;Attention deficit hyperactivity disorder;Auditory;Auditory Evoked Potentials;autism spectrum disorder;autism symptoms;autistic children;Award;Behavior;Binding;Biological;Biological Assay;biological heterogeneity;Biological Markers;Biology;biomarker performance;Brain;candidate marker;Child;Childhood;Clinic;clinic ready;Clinical;Clinical assessments;Clinical Trials;cognitive ability;Collaborations;Conduct Clinical Trials;cost;Coupled;Data;design;detection platform;Development;Diffusion Magnetic Resonance Imaging;Dimensions;Discrimination;effective therapy;efficacy evaluation;Electrodes;Electroencephalography;Electrophysiology (science);emerging adult;Environment;Exclusion;Female;Future;gamma-Aminobutyric Acid;Glutamates;Heterogeneity;imaging study;indexing;Individual Differences;individuals with autism spectrum disorder;Intervention;Laboratories;Language;life span;longitudinal design;Magnetic Resonance Spectroscopy;Magnetism;Magnetoencephalography;Measures;Menstrual cycle;Modeling;Monitor;Motor;Movement;Multimodal Imaging;multimodality;neurophysiology;Neurotransmitters;non-invasive imaging;Participant;patient stratification;peer;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Phenotype;Publications;Readiness;recruit;remediation;Research;Resolution;response;Sampling;Scanning;Sensory;Severities;sex;stability testing;Stratification;Subgroup;symptomatology;Techniques;Technology;Testing;treatment response;white matter

PROJECT_TITLE: Developing electrophysiological markers for clinical trials in autistic adults

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


PI_NAMEs: DAI, MINGJI  (contact)

PROJECT_TERMS: Acceleration;Animal Model;Animals;anti-cancer;anti-cancer research;Antineoplastic Agents;Area;Award;Basic Science;biological development;Biological Products;Biological Response Modifier Therapy;Biology;Biophysics;Cancer Biology;Cancer Center Support Grant;cancer clinical trial;Cancer Model;cancer therapy;canine model;Canis familiaris;Chemicals;clinical application;clinical center;Clinical Sciences;Clinical Trials;Collaborations;comparative;Competence;computerized tools;Development;Drug Design;drug development;drug discovery;Drug Targeting;Electrons;Evaluation;Faculty;Faculty Recruitment;Funding;Goals;Grant;Health;high throughput screening;Human;human disease;Immunologics;Indiana University Cancer Center;inhibitor;innovation;Institution;inter-institutional;interest;Investigation;Investigational Therapies;Investments;Knowledge;Lead;lead optimization;Leadership;Legal patent;Malignant Neoplasms;member;Methodology;Mission;Modality;Modeling;Molecular;Molecular Structure;Movement;NCI Center for Cancer Research;new technology;novel;novel therapeutics;Organic Synthesis;Paper;Participant;Peer Review;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phase;preclinical evaluation;preclinical study;Preclinical Testing;Process;Program Research Project Grants;programs;protein structure;Publications;Publishing;Purdue Cancer Center;rational design;recruit;Research;research clinical testing;Research Personnel;Research Support;Resolution;Scientist;Secure;small molecule;structural biology;Structure;symposium;Synthesis Chemistry;targeted agent;targeted treatment;Testing;Therapeutic;therapeutic development;tool;Training;Translating;tumor;United States National Institutes of Health;Universities;Validation

PROJECT_TITLE: Targets, Structures and Drugs (TSD)


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Nanotechnology;Orphan Drug;Prevention;Rare Diseases

PI_NAMEs: HAN, BUMSOO  (contact)

PROJECT_TERMS: Acceleration;anti-cancer research;Antineoplastic Agents;Award;Biological Sciences;Biomedical Engineering;Biophysics;Biopsy Specimen;Budgets;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cancer Detection;cancer prevention;cancer risk;cancer therapy;Canis familiaris;Cells;Chemistry;Clinical;Clinical Treatment;Clinical Trials;Collaborations;Computational Science;Data Science;design;Detection;Development;Discipline;Drug Delivery Systems;drug discovery;Drug resistance;Drug Screening;drug sensitivity;Drug Targeting;drug testing;Early Diagnosis;Electrospray Ionization;Engineering;Environmental Impact;Epigenetic Process;epigenome;Excision;Extramural Activities;Faculty;Formulation;Funding;Future;Goals;image guided;Image-Guided Surgery;imaging agent;Imaging Device;imaging modality;Imaging Techniques;Imaging technology;Immune;improved;In Vitro;innovation;Institution;inter-institutional;Interdisciplinary Study;Investigation;Leadership;Legal patent;Ligands;Light;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mass Spectrum Analysis;Measures;member;microfluidic technology;Microfluidics;mid-career faculty;Mission;Modeling;Molecular;nanoparticle;NCI Center for Cancer Research;Neoplasm Circulating Cells;new therapeutic target;novel therapeutics;Oncology;Operative Surgical Procedures;Outcome;Peer Review;Pharmaceutical Preparations;physical science;Physics;Pre-Clinical Model;Prevention;Productivity;professor;Prognosis;Program Research Project Grants;programs;Publications;Publishing;Purdue Cancer Center;Research;Research Personnel;Risk Assessment;senior faculty;sensor technology;Signal Transduction;Spectrum Analysis;Strategic Planning;Structure;superresolution microscopy;Surgical margins;System;targeted imaging;Technical Expertise;Techniques;Technology;Therapeutic Agents;Tissue Engineering;Translating;tumor;tumor microenvironment;Tumor Tissue;Universities;Validation;Work

PROJECT_TITLE: Drug Delivery and Molecular Sensing (DDMS)


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Asthma;Clinical Research;Health Effects of Indoor Air Pollution;Infectious Diseases;Lung;Pediatric;Prevention

ORG_CITY: ANN ARBOR

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Birth cohort studies have found significant associations between early-life wheezing-associated respiratory tract infections with rhinovirus (RV) and the development of asthma in children up to 13 years of age, but underlying mechanisms have been poorly studied. In this application we will test the general hypothesis that, following early-life RV infection, development of ILC2-dependent type 2 airway inflammation and mucous metaplasia represents a balance between tuft cell IL-25 signaling (promotes the phenotype) and NLRP3- dependent IL-1β production (suppresses the phenotype). Completion of the proposed work in immature mice and human infants with respiratory viral infections will provide new insight into the pathogenesis of asthma development, and identify new therapeutic targets for the asthma prevention.

PI_NAMEs: HERSHENSON, MARC B. (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: 13 year old;airway epithelium;airway hyperresponsiveness;airway inflammation;Allergens;Allergic;Asthma;asthma prevention;Attenuated;Biological Assay;Birth;Brush Cell;Canis familiaris;CASP1 gene;Cell Physiology;Cells;Chemicals;Child;Childhood Asthma;cohort;Cohort Studies;Curettage procedure;cytokine;Data;Development;eosinophilic inflammation;Epithelial Cells;Equilibrium;Flow Cytometry;Genome;Hela Cells;House Dust;Human;Immune;Immunofluorescence Immunologic;Inbred BALB C Mice;Infant;Infection;Inflammasome;Inflammation;inhibitor;insight;Interferon Type II;Interleukin-1 beta;Interleukin-13;Knockout Mice;Leukotriene E4;Life;Lower respiratory tract structure;Lung;Lymphoid Cell;Macrophage;Measures;Metaplasia;mouse model;Mucous body substance;Mus;Netherlands;Neutralization Tests;neutralizing antibody;Neutralizing antibody assay;new therapeutic target;Nose;old mice;Pathogenesis;Phenotype;Prevention;Production;Regulation;Respiratory syncytial virus;Respiratory Tract Infections;response;Rhinovirus;Rhinovirus infection;Risk;Risk Factors;Role;Shorthand;Signal Transduction;Testing;Tissues;TSLP gene;Viral;Viral Respiratory Tract Infection;Virus Diseases;Western Australia;Western Blotting;Wheezing;Wisconsin;Work;Zileuton

PROJECT_TITLE: Early Life Rhinovirus Infection and Childhood Asthma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-N(03)]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Cognitive aging is a highly complex, dynamic, and context-dependent process that is influenced by factors at the individual and societal levels The proposed research will use representative longitudinal data from the United States Health and Retirement Study and its international sister studies in England, China, and Indonesia, as well as new data obtained from the Harmonized Cognitive Assessment Protocol studies to systematically and rigorously describe and compare the relationships between cardiometabolic risk and education to cognitive function, cognitive aging, and dementia in four countries. This comparative research will enhance the understanding of ways that broad social-environmental contexts, coupled with their embedded individual characteristics and experiences, affect cognitive health in old age thus providing key insights that can be used to respond to the challenges posed by Alzheimer's Diseases (AD) and Alzheimer's Disease- Related Dementias (ADRD) worldwide.

PI_NAMEs: ZHANG, YUAN S (contact)

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: Address;Affect;Age;age related;Aging;aging population;aging process;Alzheimer's Disease;Alzheimer's disease related dementia;Award;Awareness;Biosocial;Buffers;cardiometabolic risk;Characteristics;China;Cognition;Cognitive;Cognitive aging;cognitive function;cognitive testing;comparative;Comparative Study;Complex;Country;Coupled;Data;demented;Dementia;dementia burden;dementia risk;Developed Countries;Developing Countries;Development;Diabetes Mellitus;Economic Development;Education;education pathway;Educational Status;England;Environment;Epidemiology;evidence base;experience;Exposure to;Foundations;Future;Glean;global health;Goals;Health;Health and Retirement Study;Health behavior;human old age (65+);Impaired cognition;improved;Incidence;Individual;Indonesia;innovation;insight;interest;International;Life Experience;Link;Literature;Location;Longitudinal Studies;low and middle-income countries;Medical;Mentors;Mentorship;Modeling;Nature;Neuropsychology;North Carolina;novel;nutrition;Nutritional;Obesity;older adult;Outcome;Pathway interactions;Pattern;Personal Satisfaction;Persons;Phase;Population;Prevalence;prevent;Process;protective factors;Protocols documentation;Research;Research Personnel;Risk Factors;Role;Sister;social;Techniques;Time;Training;United States;Universities;Work

PROJECT_TITLE: A cross-national comparative study on cardiometabolic risk, education, and cognitive aging

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Cancer

PROJECT_TERMS: Analytical Chemistry;Area;Basic Science;Bioinformatics;Biophysics;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cells;Computational Biology;computational chemistry;Development;Discipline;Faculty;Faculty Recruitment;faculty support;Fostering;Funding;Genomics;innovation;Leadership;Malignant Neoplasms;member;Mission;National Cancer Institute;NCI Center for Cancer Research;Pharmaceutical Chemistry;Pharmaceutical Preparations;Process;programs;Purdue Cancer Center;recruit;Research;Research Personnel;Resource Sharing;Science;Signal Transduction;Structure;Therapeutic;Universities

PROJECT_TITLE: Developmental Funds


PI_NAMEs: RATLIFF, TIMOTHY L. (contact)

PROJECT_TERMS: Advisory Committees;Basic Science;Cancer Center;Cancer Center Support Grant;Decision Making;Evaluation;Fostering;Foundations;innovation;Leadership;Malignant Neoplasms;Mission;Monitor;National Cancer Institute;NCI Center for Cancer Research;Process;Recommendation;Resources;Universities;Vision

PROJECT_TITLE: Leadership, Planning and Evaluation


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Estrogen;Women's Health Research

ORG_CITY: NEW ORLEANS

ORG_DEPT: CHEMISTRY

ORG_NAME: XAVIER UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative The proposed research is relevant to public health because it focuses on developing new and alternative strategies to treating ER+ metastatic breast cancer. Orally bioavailable, irreversible ER inhibitors offer more durable clinical response and prolong patient survival by permanently eliminating ER-dependent breast cancer cell proliferation. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to enhancing health and reducing mortality rate.

PI_NAMEs: PAYTON-STEWART, FLORASTINA L (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Address;adjuvant endocrine therapy;Affinity;Agonist;Amino Acids;antagonist;Aromatase Inhibitors;benzothiophene;Binding;Binding Proteins;Biological Assay;Biological Availability;Breast;Breast Cancer Cell;breast cancer diagnosis;Breast Cancer Model;Breast Cancer Patient;Breast Cancer therapy;Caco-2 Cells;Cell Proliferation;Clinic;Clinical;clinical development;clinically relevant;covalent bond;Cysteine;Cytochrome P450;Death Rate;design;Development;Disease;Disease Progression;Dose;drug candidate;Drug Exposure;Drug Kinetics;Endocrine;Enzymes;ESR1 gene;Estrogen Antagonists;Estrogen Receptors;Estrogen Therapy;Exhibits;Fulvestrant;Genetic Transcription;Goals;Growth;Health;hormone therapy;In Vitro;in vivo;Individual;inhibitor;innovation;Innovative Therapy;Laboratories;Lead;Letrozole;Ligand Binding Domain;Malignant Breast Neoplasm;Mass Spectrum Analysis;Measures;Mediating;Metabolic;Metastatic breast cancer;Mission;Molecular;mutant;Mutation Detection;Neoplasm Metastasis;novel;Oral;Outcome;patient derived xenograft model;patient population;Patients;Permeability;Pharmacodynamics;Pharmacologic Actions;Plasma Proteins;preclinical efficacy;preclinical study;Productivity;Proliferating;Proteomics;prototype;Public Health;Raloxifene;receptor binding;Relapse;Reporter;Reporting;Research;Resistance;response;Selective Estrogen Receptor Modulators;side effect;Somatic Mutation;standard of care;Structure;Tamoxifen;Testing;Therapeutic;Therapeutic Agents;Thiophenes;Tissues;transcriptome sequencing;Treatment Efficacy;Triphenylethylene;tumor;tumorigenesis;United States National Institutes of Health;Work

PROJECT_TITLE: Irreversible Estrogen Receptor Inhibitors


NIH_SPENDING_CATS: Bioengineering;Cannabinoid Research;Networking and Information Technology R&D (NITRD)

ORG_CITY: Los Angeles

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: NARRATIVE The slow pace of drug discovery is often defined by a limited pool of chemical compounds used to detect drug candidates, usually one or a few million. Recent studies suggest that expanding this pool to billions or even trillions of compounds in silico can improve the quality of identified candidates. Our new technology, V- SYNTHES, provides a fast and cost-effective way to perform such Giga- and Terra-scale screening, greatly streamlining early discovery efforts even for more challenging targets.

PI_NAMEs: KATRITCH, VSEVOLOD  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Adoption;Affinity;Algorithms;analog;Benchmarking;Binding;candidate identification;cannabinoid receptor;cannabinoid receptor antagonist;chemical synthesis;Chemicals;clinically relevant;Cloud Computing;CNR1 gene;CNR2 gene;Code;Collaborations;combinatorial;Communities;computational platform;computing resources;cost;cost effective;Cyclic AMP-Dependent Protein Kinases;Development;Docking;drug candidate;drug discovery;Drug Discovery Groups;drug quality;drug testing;drug-like compound;Ensure;G-Protein-Coupled Receptors;Geometry;Goals;Growth;improved;in silico;Institution;Lead;Letters;Libraries;Ligands;Linux;Lipid Binding;Machine Learning;Nature;new technology;novel;novel strategies;Nucleotides;open source;Orphan;Phosphotransferases;portability;Positioning Attribute;Property;prospective;Proteins;Pythons;rapid detection;rapid growth;Reaction;receptor;Research;Resolution;ROCK1 gene;scaffold;scale up;screening;Structure;Technology;Testing;therapeutic target;Validation;virtual;virtual library;virtual screening;Work;Writing

PROJECT_TITLE: Efficient synthon-based modular screening of Giga-to-Terra-scale virtual libraries

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Nanotechnology;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: EAST LANSING

ORG_DEPT: PHARMACOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on developing a novel approach to producing therapeutic extracellular vesicles (EVs) for treating chronic inflammatory diseases. Once such strategies have been developed, there is the potential for a significant ad- vance in the successful translation of EV-based therapy to the clinic. The goal of our Trailblazer project is relevant to the part of the NIH's mission that pertains to reducing illness and disability.

PI_NAMEs: KANADA, MASAMITSU  (contact)

PROGRAM_OFFICER_NAME: CHEN, JERMONT

PROJECT_TERMS: 3-Dimensional;Anti-Inflammatory Agents;Antiinflammatory Effect;Biophysical Process;Cell membrane;Cells;Characteristics;Chemicals;chronic inflammatory disease;Circulation;Clinic;clinical application;Clinical Research;Clinical Treatment;Communities;cost effective;cytokine;cytotoxicity;delivery vehicle;Detection;disability;Disease;Distant;DNA;Drug Delivery Systems;Economic Burden;Encapsulated;Endothelium;Engineering;Environment;Extracellular Matrix;extracellular vesicles;Foundations;Future;Generations;Genes;Goals;Health;Hydrogels;Immune Evasion;In Vitro;in vivo;innovation;Interleukin-10;Intestines;Kidney;Liposomes;Liver;Mammalian Cell;mechanical properties;mechanical signal;Mechanical Stimulation;Mechanics;Mediating;Membrane Proteins;Mesenchymal Stem Cells;Messenger RNA;Methods;Mission;Modeling;nanomedicine;nanoparticle;Nanotechnology;novel;novel strategies;Patients;Penetration;Periodicity;Pharmaceutical Preparations;Physiologic pulse;Physiological;Plasmids;preclinical study;Production;Property;Proteins;Public Health;Research;Safety;small molecule;Solid;sonoporation;Spleen;Stretching;Surface;synergism;System;targeted delivery;Techniques;Technology;Testing;Therapeutic;Therapeutic Effect;therapeutically effective;three dimensional cell culture;Time;Tissues;Toxic effect;Transfection;Translating;Translations;Transmembrane Transport;Treatment Efficacy;ultrasound;United States National Institutes of Health;Untranslated RNA;vector;Vesicle;vesicular release;viscoelasticity

PROJECT_TITLE: Ultrasound-assisted extracellular vesicle engineering and induced release: EVEiR

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-P(80)S]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: BERKELEY

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE The proposed aging center will study societal changes leading to an aging society – low fertility, longer life expectancy – as well as the effects of behavioral changes (e.g., obesity, smoking) at the level of the individual and society, and consider the adequacy of our decision making capabilities in the face of these challenges. CEDA will provide the infrastructure and support for fostering innovative research, conferences and other collaborations, and dissemination of data for analysis by researchers, policy-makers and others. Ultimately, the focus and structure will advance the development of theories and empirical data to address complex interrelationships underlying healthy aging and therefore lead to policies for improved public health.

PI_NAMEs: DOW, WILLIAM H. (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Address;Adult;Advanced Development;Affect;Aging;aging demography;aging population;aging related;Applications Grants;Area;Basic Science;Behavior;behavior influence;Behavioral;behavioral and social science;behavioral economics;Behavioral Mechanisms;biodemography;Biology;causal model;Collaborations;Complex;cost;Country;Coupled;Data;Data Analyses;data dissemination;Data Set;Databases;Decision Making;Demographic Transitions;Demography;Development;Discipline;Disparate;Economic Policy;Economics;Educational workshop;Empirical Research;Epigenetic Process;Faculty;family support;Fertility;Fertilization;Fostering;Funding;Future;Genomics;Grant;Health;health determinants;Health Resources;healthy aging;High Performance Computing;Human;human mortality;improved;Individual;Influentials;Infrastructure;innovation;insight;International;Lead;Leadership;Life Cycle Stages;Life Expectancy;Measurement;Measures;Methodology;Methods;migration;Mission;model organism;Modeling;mortality;Obesity;older adult;Outcome;Pilot Projects;Policies;Policy Maker;Population;Population Analysis;population based;population health;Productivity;Public Health;Public Policy;Research;Research Personnel;Research Project Grants;Research Support;Resources;Role;San Francisco;Science;Series;Shapes;Smoking;Societies;statistics;Structure;support network;symposium;Technology;Testing;theories;Time;tool;Training Programs;Translational Research;Translations;United States;United States National Academy of Sciences;Universities;user-friendly;Vital Statistics;Work

PROJECT_TITLE: Center on the Economics and Demography of Aging


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science

PROJECT_TERMS: Address;Administrator;aging demography;aging related;Applications Grants;Award;Bayesian Modeling;Budgets;Calendar;Censuses;Collaborations;Communication;Community Health;Computer Hardware;Computer software;Data;Data Analyses;data resource;Data Science;Data Security;Data Set;Demography;design;Development;Economics;Educational workshop;Environment;Event;Expenditure;Faculty;Fostering;Funding;Funding Opportunities;Government Agencies;graduate student;Grant;health economics;Historical Demography;Individual;Infrastructure;innovation;interest;Leadership;Learning;meetings;Mission;Monitor;Newsletter;Outcome;Output;Pilot Projects;population health;Population Sciences;Positioning Attribute;Postdoctoral Fellow;Preparation;Progress Reports;Provider;Public Health Schools;Publications;Publishing;Records;recruit;Reporting;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resource Allocation;Resources;Role;Secure;Service provision;Services;Sister;skills;Solid;Structure;symposium;tool;Training;Universities;user-friendly;Visit;visiting scholar;web site

PROJECT_TITLE: Core A. Administrative and Research Support


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Social Determinants of Health

PI_NAMEs: GOLDSTEIN, JOSHUA R. (contact)

PROJECT_TERMS: Address;Adult;Affect;age effect;Aging;aging demography;aging population;aging related;Articulation;Behavior;Behavioral;behavioral economics;Behavioral Sciences;biodemography;career;caregiving;Caring;Ceratitis capitata;Cessation of life;Collaborations;Computer software;Consumption;Country;Data;data access;Death Rate;Demography;Development;Drosophila genus;Economics;Faculty;Feedback;Fostering;Foundations;frontier;Funding;Goals;Health;healthspan;high reward;high risk;Human;innovation;instrument;International;Internet;Knowledge;Life;Measurable;Measurement;meetings;member;Methods;model organism;Modeling;mortality;Outcome;Pilot Projects;pilot test;pilot trial;Policies;population health;Process;Program Development;Reporting;Reproduction;Research;Research Personnel;Research Project Grants;Resources;Role;sleep pattern;smoking cessation;Social Network;Societies;success;sugar;Technology;theories;Time;United States National Institutes of Health;Work

PROJECT_TITLE: Program Development (Pilot)


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Mental Health;Patient Safety;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_NAME: HENNEPIN HEALTHCARE RESEARCH INSTITUTE

ORG_STATE: MN

PHR: PROJECT NARRATIVE Dr. Jenell Stewart is an infectious diseases clinician-scientist at the University of Washington proposing a career development training plan and clinical research focused on gaining expertise in design and analysis of adherence in STI and HIV prevention trials, behavioral science methods for evaluation of sexual and adherence behaviors, and mixed-methods evaluation of gender-based power differentials relationship with prevention behavior. This proposal leverages the only clinical trial of doxycycline post-exposure prophylaxis (dPEP) STI prevention among young women – a target population for HIV and STI prevention - which will be launching in early 2020 in Kenya. We will evaluate the impact of adherence to dPEP on bacterial STIs (chlamydia, gonorrhea, and syphilis with the addition of emerging STI, Mycoplasma genitalium) as well as the impact of point-of-care STI diagnosis on longitudinal prevention behavior contextualized in the gendered power dynamics of primary partnerships.

PI_NAMEs: STEWART, JENELL  (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: Adherence;adverse pregnancy outcome;African;African Women;Age;AIDS prevention;Antibiotics;Area;arm;Award;Behavior;Behavioral Sciences;Biological;career;career development;Caring;Chlamydia;Chlamydia trachomatis;chronic pain;Client;Clinical;clinical epidemiology;Clinical Research;clinical trial analysis;Clinical Trials;Cohort Analysis;Collaborations;Communicable Diseases;compliance behavior;Counseling;Country;Data;Dedications;design;Diagnosis;Doxycycline;Effectiveness;empowerment;Enrollment;Epidemic;epidemiology study;Equation;Etiology;Evaluation;Event;experience;Female Adolescents;Focus Groups;Frequencies;Future;Gender;gender equity;Gonorrhea;Hair;Healthcare;HIV;HIV Infections;HIV prevention trial;HIV risk;improved;Incidence;Income;Individual;Inequity;Infection Control;infection rate;International;Interpersonal Violence;Interview;Investigation;Kenya;longitudinal analysis;low and middle-income countries;Mainstreaming;male;Measures;men who have sex with men;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Monitor;Morbidity - disease rate;mortality;multidisciplinary;Mycoplasma genitalium;Neisseria gonorrhoeae;novel;parent grant;Parents;pathogen;peer;Pelvic Inflammatory Disease;Pharmaceutical Preparations;Physicians;point of care;Policies;Population;pre-exposure prophylaxis;Pregnancy Complications;prevent;Prevention;Prevention strategy;programs;Prophylactic treatment;PSA screening;Questionnaires;randomized trial;Reporting;Research;Research Personnel;Resource-limited setting;response;Risk;Risk Behaviors;Risk Reduction;Sampling;Scientist;secondary analysis;self reported behavior;Sex Behavior;sexual relationship;Sexually Transmitted Diseases;STI prevention;Surveys;Syphilis;Target Populations;Tenofovir;Testing;Training;Training Programs;Treponema pallidum;tubal infertility;Universities;Unsafe Sex;Vagina;violence exposure;Washington;Woman;women's prevention;Work;young woman

PROJECT_TITLE: Understanding STI and HIV prevention adherence among Kenyan women

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Genetics;Neurosciences;Nutrition;Pediatric;Prevention

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the results are expected to have an important positive impact, either by offering reassurance about the safety of DHA-supplemented products for young children born preterm, or by bringing attention to adverse long-term effects and steering the field toward seeking new interventions and further examination of mechanisms for adverse effects. The project is relevant to the mission of the Eunice Kennedy Shriver National Institute of Child Health and Human Development because it is expected to open new horizons toward effective and safe interventions to support the neurodevelopment of children born preterm, thereby ensuring all children have the chance to achieve their full potential for healthy and productive lives.

PI_NAMEs: KEIM, SARAH  (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: 1 year old;Accounting;Adverse effects;Age;Alleles;Alternative Therapies;Arachidonic Acids;arm;Attention;Back;Biological;Birth Weight;blind;Blood;Brain;Child;Clinical;cognitive ability;cognitive benefits;Cognitive deficits;cognitive development;cohort;Consumption;cost;Data;Development;Diet;Dietary Fatty Acid;dietary supplements;Early Intervention;Ensure;Equilibrium;Evaluation;Executive Dysfunction;executive function;Exhibits;extreme prematurity;Family;Fatty Acid Desaturases;fatty acid metabolism;fatty acid supplementation;Fatty Acids;follow up assessment;Food;Genes;Genetic;Genetic Polymorphism;genetic variant;Genetic Variation;Goals;Heritability;high risk;Impairment;improved;infancy;Infant formula;informant;innovation;insight;Intervention;intervention program;Language;Language Development;Language Disorders;Learning;Literature;long chain fatty acid;Long-Term Effects;Measures;Methods;Minor;Mission;National Institute of Child Health and Human Development;Neurocognitive Deficit;neurodevelopment;Neurologic Process;Observational Study;Omega-3 Fatty Acids;Omega-6 Fatty Acids;Outcome;Outcome Assessment;Parents;Participant;Performance;Persons;Placebos;Population;Premature Infant;Problem behavior;Productivity;Prospective cohort;Public Health;Publishing;Randomized;randomized placebo controlled trial;Recommendation;Reporting;Research;Risk;Role;Safety;Saliva;School-Age Population;Schools;Sex Differences;socioeconomics;Specific qualifier value;Subgroup;Supplementation;teacher;Testing;Time;Toddler;treatment effect;Very Long Chain Fatty Acid;virtual;Visual

PROJECT_TITLE: Long-term Effects and Safety of DHA Supplementation in Toddlerhood for Children born Preterm

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: WACHTER, KENNETH WILLCOX (contact)

PROJECT_TERMS: Aging;aging demography;Area;Biological;Canada;cardiovascular health;Censuses;Child;Collaborations;Communication;Communities;comparative;Complement;complex data;Country;Cuba;Data;Data Science;Data Set;data sharing;Databases;Demography;Development;Discipline;early life adversity;Economics;Education;Educational workshop;European;Event;Fostering;France;Funding;Gender;Geography;Health;Healthcare;healthspan;Human;human mortality;Income;Inequality;innovation;Institution;interest;Intergenerational transfer;International;Investments;Israel;Knowledge;labor force participation;late life;Learning;Life Cycle Stages;life span;Link;Logistics;meetings;member;Methodology;Methods;Mexico;mortality disparity;novel;Online Systems;Outcome;Paper;Persons;Policies;Policy Maker;programs;Race;Research;research and development;Research Personnel;Research Project Grants;Retirement;Side;Social Mobility;Social Network;success;support network;symposium;Techniques;Technology;theories;Time;Training;Travel;undergraduate student;virtual;Visit;visiting scholar;web site;webinar;Work

PROJECT_TITLE: Core C. External Innovative Network Core:


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cardiovascular;Clinical Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: HADLEY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: Project Narrative The goal is to design and implement a novel wearable vest able to collect multiple-channel transthoracic bioimpedance measurements obtained from reusable dry electrodes to accurately detect intrathoracic volume retention and predict ADHF. The system will consist of a bioimpedance and ECG monitor (a wearable vest with dry electrodes—no adhesives, gels, or wetting required) that transmits its data to a smartphone that has a mobile application to detect early ADHF using ML-based algorithms, and additionally, a cloud server application will monitor data reliability from the in-home setting and reduce medical staff workload from wearable device setting and unnecessary medical intervention. The system will require the development of a novel data acquisition circuit, wearable vest, signal processing and ML algorithms, and a cloud-based data communication system.

PI_NAMEs: NOH, YEONSIK  (contact)

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: Acute;Adhesives;Affect;Age;Algorithms;American;Back;Bluetooth;Body Weight;Carbon Black;Cardiac;Cardiovascular Diseases;Cellular Phone;Chest;Chronic;Clinical;clinical decision support;Clinical Research;cloud based;Cloud Computing;cloud platform;Cohort Studies;Collection;Congestive Heart Failure;connected health;Connecticut;Data;data acquisition;Data Collection;data communication;data exchange;data quality;design;Detection;detection platform;Development;Devices;Diuretics;Dryness;Early Diagnosis;Early identification;Elderly;electric impedance;Electrocardiogram;Electrodes;Feasibility Studies;Feedback;flexibility;Frustration;Gel;Goals;Grant;Heart failure;Heart Rate;heart rate variability;heart rhythm;high risk;Home;Hospital Costs;hospital readmission;Hospitalization;Hour;Human;Impairment;improved;Information Storage;innovation;interest;Intervention;Lead;Learning;Leg;Light;Liquid substance;Lung;Machine Learning;machine learning algorithm;machine learning model;Massachusetts;Measurement;Measures;Medical;medical attention;medical schools;Medical Staff;mobile application;Monitor;Morbidity - disease rate;Morphologic artifacts;mortality;multidisciplinary;new technology;Noise;novel;Oral;patient oriented;Patients;Performance;Persons;Pharmaceutical Preparations;Physiological;polydimethylsiloxane;Population;pressure;prevent;programs;prospective;prototype;Quality of life;Questionnaires;recruit;Reporting;research clinical testing;respiratory;Risk;Risk Factors;Running;sensor;sex;Shortness of Breath;signal processing;Signal Transduction;Signs and Symptoms;Site;Skin;SMART health;smartphone application;Spectrum Analysis;Staff Work Load;Swelling;Symptoms;System;technology development;telehealth;Testing;Time;Titrations;Training;transmission process;trend analysis;Universities;usability;wearable device;web site;Weight;Weight Gain;wireless communication;wireless fidelity

PROJECT_TITLE: In-home wearable system to detect early-stage decompensation in heart failure patients

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Social Determinants of Health

PI_NAMEs: LEE, RONALD D (contact)

PROJECT_TERMS: aging demography;aging population;Back;Caring;Cause of Death;Censuses;Collection;Communities;Computer software;Country;County;Data;Data Analyses;Data Set;Databases;Decision Making;Demography;design;Development;Documentation;Economics;Educational process of instructing;Educational workshop;experience;Faculty;Gender;Government;Government Agencies;Grant;Home;human mortality;improved;innovation;Institution;International;International Agencies;Knowledge;Lesbian Gay Bisexual;Life Tables;Link;Longitudinal Studies;Manuals;media use;member;Methods;Modality;Modeling;mortality;new technology;Newsletter;older adult;Outcome;Output;Persons;Policies;Policy Maker;Population;Preparation;Printing;Privatization;Production;programs;Quality Control;Reporting;Research;Research Activity;Research Personnel;Resources;response;Role;Series;social media;Social Network;software development;Students;success;Surveys;time use;Training;Training Programs;United Nations;United States National Academy of Sciences;Update;user-friendly;web site;Work;World Bank;Writing

PROJECT_TITLE: Core D. External Research Resources Support and Dissemination


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Human Genome;Prevention

PHR: Project Narrative Cataract, the most common cause of vision impairment worldwide and usually related to aging, is impacted by both genetic and non-genetic factors. In this proposal, we will determine the role of genetic and non-genetic factors that increase one’s risk to develop cataract and we will develop a tool that predicts one’s probability of developing cataract. A better understanding of the reasons why some patients are more likely than others to develop cataract is crucial to develop personalized interventions for at-risk patients.

PI_NAMEs: CHOQUET, HELENE  (contact);LACHKE, SALIL

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Accounting;Affect;age related;Aging;Alcohol consumption;Animal Model;Behavioral;biobank;Biological;Blindness;Body mass index;Candidate Disease Gene;Cataract;Cataract Extraction;causal variant;CD100 antigen;Cellular Assay;Cigarette;cigarette smoking;Clinical;Clinical Data;Code;cohort;conditional knockout;cost;Crystalline Lens;Data;Databases;Defect;Development;Diabetes Mellitus;Disease;disorder risk;effective intervention;Electronic Health Record;Etiology;exome sequencing;Eye;fall injury;gene discovery;Gene Expression;Genes;Genetic;genetic predictors;Genetic Transcription;genome wide association study;genome-wide;genomic locus;Genotype;Glaucoma;Goals;high body mass index;Histology;Homeostasis;Hypertension;improved;Individual;innovation;insight;Investigation;knockout gene;Knockout Mice;Knowledge;lens;Lens Opacities;Link;Literature;Medicare;Mendelian randomization;Meta-Analysis;Molecular;mortality;mouse model;multi-ethnic;multiple datasets;Myopia;new therapeutic target;non-genetic;novel;novel strategies;Observational Study;Operative Surgical Procedures;Participant;Pathogenesis;Pathology;Pathway interactions;Patients;Performance;personalized intervention;polygenic risk score;Population;predictive modeling;predictive tools;Predisposition;prevent;Prevention;Prevention strategy;Probability;programs;Proteomics;Public Health;Refractive Errors;Regulation;Research;Risk;Risk Factors;risk prediction;risk prediction model;risk stratification;risk variant;Role;Scanning Electron Microscopy;screening;Smoking;System;Testing;Therapeutic;Therapeutic Intervention;Tissues;tool;trait;transcriptome;transcriptome sequencing;Variant;Vision;Visual Acuity;Visual impairment

PROJECT_TITLE: The Role of Genetic and Non-Genetic Factors and Causal Mechanisms Underlying Cataract Susceptibility For Risk Prediction

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Asthma;Clinical Research;Genetics;Human Genome;Lung;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Despite the significant public health burden of childhood asthma, no effective prevention strategies currently exist; this is due in part to our limited understanding of the molecular determinants of asthma pathogenesis. This proposal aims to elucidate metabolic and genetic pathways underlying childhood asthma pathogenesis. Successful completion of these a priori formulated research questions and the application of rigorous study designs and analyses will provide important insights on the role of metabolic dysfunction in the development of childhood asthma, identify novel metabolic and gene targets that confer differential disease susceptibility, and advance our understanding of disease pathogenesis.

PI_NAMEs: SNYDER, BRITTNEY M (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Address;Applied Skills;Asthma;Award;Birth;career;career development;Child;Child Health;Childhood;Childhood Asthma;Clinical;cohort;Communication;Data;design;Development;Development Plans;Disease;Disease Pathway;Disease susceptibility;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiologist;Epidemiology;epidemiology study;Etiology;experience;Gene Targeting;Genetic;genetic epidemiology;Genetic Risk;genetic variant;Genome;genome wide association study;genome-wide;Genotype;Goals;improved;in utero;insight;Institution;Knowledge;Knowledge acquisition;Leadership;Life;Link;Lower Respiratory Tract Infection;Manuscripts;Maternal and Child Health;Mediating;Mediation;Mentors;Mentorship;Metabolic;Metabolic dysfunction;metabolic profile;metabolome;metabolomics;Modernization;Molecular;multidimensional data;Neonatal Screening;Newborn Infant;novel;Outcome;Pathogenesis;Pathway interactions;phenotypic data;prevent;Prevention;Prevention strategy;Primary Prevention;programs;Public Health;Research;Research Design;Research Personnel;Resources;Respiratory Disease;Risk Factors;Role;Scientific Advances and Accomplishments;skills;Statistical Methods;statistics;Testing;Training;Training Activity;translational genetics;United States National Institutes of Health;Variant;Wheezing;Work

PROJECT_TITLE: Identifying molecular pathways in childhood asthma pathogenesis by integrating newborn metabolic profiles and GWAS data

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE  The basal ganglia are a set of brain nuclei highly conserved among vertebrates, including humans, critical for motor control and trial-and-error learning. This proposal will leverage advantages of a highly tractable model system, the songbird, to determine how the basal ganglia control and evaluate motor performance, two processes that go awry in a wide variety of basal ganglia diseases.

PI_NAMEs: GOLDBERG, JESSE HEYMANN (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Anatomy;Animals;Area;Auditory;Auditory area;Basal Ganglia;Basal Ganglia Diseases;Behavior;Behavioral;Benchmarking;Biological Models;Birds;Brain;Cell Nucleus;cholinergic;cholinergic neuron;Complex;Data;Deep Brain Stimulation;Disease;Dopamine;dopaminergic neuron;Emotional;Ensure;Evaluation;Exhibits;experience;experimental study;Female;Future;Globus Pallidus;Grant;Habenula;hedonic;Human;improved;individualized medicine;innovation;instrument;Juice;Knowledge;laboratory experience;Lateral;Learning;Lesion;Limbic System;male;Mammals;Methods;microstimulation;Motivation;Motor;motor control;Motor Cortex;motor learning;Movement Disorders;Music;neural;neural circuit;neural correlate;neuromechanism;Neurons;novel;Outcome;outcome prediction;Output;Pathologic;Pathway interactions;Pattern;Performance;Physiology;Population;Primates;Process;Punishment;Research;response;Rewards;Role;Route;Self-Examination;sequence learning;Signal Transduction;Songbirds;Speech;Sports;Structure;Structure of subthalamic nucleus;System;Testing;Ventral Tegmental Area;Vertebrates;Work

PROJECT_TITLE: Neural Mechanisms of Performance Evaluation During Motor Sequence Learning

STUDY_SECTION: SMI

STUDY_SECTION_NAME: Sensorimotor Integration Study Section[SMI]


ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Every cell in the human body contains many somatic DNA mutations, and these mutations have an impact of human development, diseases such as cancer and epilepsy, and aging. We have shown that studying these mutations also provide key insights into the development of the human brain, which is a fundamental question of neuroscience. This proposal aims to analyze the somatic mutations in the human brain that occur during development to create a developmental map of the human brain.

PI_NAMEs: WALSH, CHRISTOPHER A. (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Adult;Aging;Algorithms;Animal Model;Architecture;autism spectrum disorder;Autopsy;Bar Codes;Birth;Brain;brain cell;Brain region;brain size;brain surgery;Brodmann's area;Cell Cycle;Cell division;Cell Lineage;cell type;Cells;Cerebral cortex;childhood epilepsy;Cognitive;Communities;Copy Number Polymorphism;Data;dentate gyrus;Development;Disease;DNA;DNA analysis;DNA Integration;DNA Mutational Analysis;DNA Sequence Alteration;Epilepsy;excitatory neuron;expectation;experimental study;Fetal Development;Forensic Medicine;Funding;Gene Expression;Gene Expression Profile;Genetic;Genetic Transcription;Genome;genome sequencing;Goals;Grant;Hippocampus;Human;Human body;Human Development;human disease;Inherited;inhibitory neuron;insight;Intellectual functioning disability;Life;Malignant Neoplasms;Maps;Measures;Mental disorders;Methods;mosaic;Mosaicism;Mutation;Neocortex;Nerve Degeneration;Nervous System Disorder;neural;Neurodevelopmental Disorder;Neuroglia;Neurons;Neurosciences;Pattern;postmitotic;postnatal development;Predisposition;Prefrontal Cortex;prenatal;Primates;Publishing;Retrotransposon;RNA;RNA analysis;Sampling;Single Nucleotide Polymorphism;Somatic Cell;Somatic Mutation;Structure;Surface;Technology;Temporal Lobe;Temporal Lobe Epilepsy;Testing;tool;Visual Cortex;Work

PROJECT_TITLE: Cell Identity Determination In Human Brain: Somatic Mutation and Cell Lineage

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Immunization;Immunotherapy;Infectious Diseases;Vaccine Related

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Project Narrative Studies proposed here aim at establishing a new type of live attenuated bacterial vaccine vector that effectively generates intestinal antigen-specific CD8+ tissue resident memory (TRM) cells. If proved, this new vaccine vector will be safe, effective, able to generate different types of TRM cells and suitable for repeated vaccination. With other benefits offered by live attenuated bacterial vaccine vectors, such as controllability through antibiotic treatment, ease of production, storage and transportation, and economic advantages, this new type of vaccine vector may revolutionize vaccine development and even cancer immunotherapies.

PI_NAMEs: ZHANG, YUE  (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Antibiotic Therapy;Antibiotics;Antibody Response;Antigen-Presenting Cells;Antigenic Specificity;Antigens;Attenuated;Attenuated Vaccines;Bacteria;Bacterial Vaccines;C57BL/6 Mouse;cancer immunotherapy;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell secretion;Cells;Characteristics;combat;Communicable Diseases;Cross Presentation;cytokine;Cytosol;cytotoxic CD8 T cells;Dendritic Cells;Economics;Epitopes;Eukaryotic Cell;foodborne infection;Foundations;Generations;Genes;Genome;Human;Immune response;Immunocompetent;immunogenicity;improved;Individual;Infection;Inflammatory;Injections;Interferon-beta;Interleukin-12;Intestines;Intravenous;Investigation;Memory;Mesenteric Lymphadenitis;mouse model;Mus;mutant;Mutation;novel vaccines;Pasteurella pseudotuberculosis;pathogen;pathogenic bacteria;Phagocytes;Positioning Attribute;Production;Proteins;Role;Signal Pathway;T cell response;tissue resident memory T cell;Tissues;transcriptome;Transforming Growth Factors;Transportation;Type III Secretion System Pathway;Vaccination;vaccine development;vector vaccine;vector-based vaccine;Virulence;Virus Diseases;Yersinia pseudotuberculosis Infections

PROJECT_TITLE: Generation of CD8+ Tissue-Resident Memory T cell response during Yersinia pseudotuberculosis foodborne infection

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


NIH_SPENDING_CATS: Aging;Genetics;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CINCINNATI

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Autophagy is an essential cellular function that plays crucial roles in a variety of biological and disease processes. The characterization of key autophagy genes including their autophagy and non-canonical functions in the regulation of NSC maintenance and neurogenesis in young and aged animals will significantly advance our understanding of the molecular and cellular mechanisms of NSC regulation that will contribute to new treatments for neurodegenerative and related diseases.

PI_NAMEs: GUAN, JUN-LIN  (contact)

PROJECT_TERMS: Ablation;Adult;Affect;age-related disease;aged;Aging;Alzheimer's Disease;animal old age;Autophagocytosis;Biochemical;Biological;Brain;C-terminal;cell age;Cell Maintenance;Cell model;Cell Physiology;Cells;Complex;conditional knockout;Cytoplasm;Data;Defect;design;Development;Disease;Disease Progression;Dominant-Negative Mutation;effective therapy;Family;Functional disorder;Funding;Future;gain of function;Generations;Genes;Genetic;Goals;Growth;Homeostasis;Huntington Disease;Hydrogen Peroxide;Hypoxia;In Vitro;in vivo;Injury;insight;juvenile animal;Knock-in;Knock-in Mouse;Knockout Mice;Laboratories;Maintenance;Metabolic;Modeling;Molecular;mouse model;Mus;Mutagenesis;Mutation;Nerve Degeneration;nerve stem cell;Neurodegenerative Disorders;neurogenesis;neuromechanism;Neurons;neuroregulation;Organ;Oxidative Stress;Parkinson Disease;Phosphorylation;Play;prevent;Process;Proteins;PTK2 gene;receptor;Regulation;response;Risk Factors;Role;stem cells;synergism;TBK1 gene

PROJECT_TITLE: Regulation of Neural Stem Cells and Neurogenesis by Autophagy Genes

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: BOSTON

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project narrative: Most respiratory training programs are housed within centers of clinical medicine and focus on the interface between basic respiratory science and clinical or translational science, whereas ours is housed within a school of public health and focuses on the intersection between basic respiratory science and environmental exposure, often in the context of global public health. From its inception 44 years ago, this T32 training program has emphasized quantitative sciences –engineering sciences, physical sciences, and population sciences– and in recent years has embraced data sciences and quantitative genomics. By integrating these quantitative sciences with cutting edge lung biology and pathophysiology, we provide each trainee with perspectives, interdisciplinary skills, and exceptional expertise that, taken together, prepares each one to launch a productive career in contemporary lung research.

PI_NAMEs: LU, QUAN  (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TITLE: Training Program in Molecular and Integrative Physiological Sciences


NIH_SPENDING_CATS: Genetics

PHR: Narrative tRNA-fragments (tRFs) are an emerging class of small regulatory RNAs with the ability to regulate all facets of gene expression. tRFs have been implicated in cancer, neurogenerative disease, viral infection, fertility, and aging, although little is known about tRF biogenesis, regulation, and molecular functions throughout the different tissues of an organism. We are developing the worm C. elegans as a model to address these questions, thereby providing the first systematic analysis of how tRFs are made and function throughout an animal to regulate cellular physiology.

PI_NAMEs: CONINE, COLIN  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Address;Adult;Affect;Aging;Alleles;Animals;Biochemical;Biogenesis;Biological Assay;Biology;Caenorhabditis elegans;Cell Physiology;Cells;Data Set;Disease;Dissection;Enzymes;Epigenetic Process;Fertility;forward genetics;Gene Expression;Genes;Genetic;Genetic Transcription;Human;Learning;loss of function mutation;Malignant Neoplasms;Modeling;Modification;Molecular;mRNA Stability;mutant;Nematoda;Neurodegenerative Disorders;Organism;Physiological;Physiology;Plant Physiology;Play;Post-Transcriptional Regulation;Publishing;Regulation;reverse genetics;RNA;RNA Stability;Role;Small RNA;System;Techniques;Tissues;tool;Transcriptional Regulation;transcriptome sequencing;Transfer RNA;Translations;Virus Diseases;Whole Organism;Work;Yeasts

PROJECT_TITLE: Developing C. elegans as a model to understand tRNA-fragment biogenesis and function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-J(55)R]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Digestive Diseases;Health Services;Nutrition;Palliative Care;Patient Safety;Pediatric;Prevention

PHR: PROJECT NARRATIVE Children with medical complexity who require enteral feeding support are a significant driver of total pediatric health care expenditure, with high rates of gastroesophageal reflux and feeding intolerance that are exacerbated by conventional enteral formulas. We hypothesize that blenderized diets (pureed table foods administered via enteral tube) present a superior alternative approach for this vulnerable population due to their increased viscosity, and propose an innovative randomized controlled trial to test this hypothesis. Through this career development award, I will systematically investigate the effects of blenderized diets on esophageal and gastric function, acquire expertise in food sciences to further modify and improve blenderized diets, and learn statistical techniques critical for analysis of personalized nutrition interventions.

PI_NAMEs: HRON, BRIDGET MARY (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Address;Admission activity;Adopted;Adult;Advisory Committees;Affect;Aspiration Pneumonia;Berry;Biometry;Bolus Infusion;Boston;burden of chronic illness;career;catalyst;chemical property;Child;Child health care;Childhood;Classification;Clinical;clinical care;Clinical Management;Clinical Research;Clinical Trials;Coughing;Coupled;course development;Cross-Over Studies;Data;Deglutition;Dependence;design;Development;diaries;Diet;Dietary Intervention;Disease;Enteral;Enteral Feeding;Environment;Esophagus;Event;evidence base;Expenditure;experience;Fabaceae;feeding;Feeds;Food;food science;Fruit;Functional disorder;Fundus;Future;Gastric Emptying;Gastroenterologist;Gastroesophageal reflux disease;gastrointestinal;gastrointestinal symptom;Gastroparesis;Gastrostomy;Goals;Health;Health Care Costs;health care service utilization;Health Expenditures;Heterogeneity;Hospitalization;Illinois;Impairment;improved;indexing;Individual;Infant;Inferior esophageal sphincter structure;Inflammation;Ingestion;innovation;Instruction;intervention effect;Investigation;K-Series Research Career Programs;Literature;Location;Lung;Macronutrients Nutrition;Master of Science;Measures;Meat;Mediator;Medical;medical schools;Medical Technology;Medicine;Mentors;Mentorship;Metabolism;Methodology;Methods;Micronutrients;Motility;Nausea and Vomiting;Neurologic;novel;novel marker;nutrition;Nutritional;Observational Study;Outcome;Parents;Participant;Patients;Pediatric Hospitals;personalized nutrition;physical property;Physicians;Physiological;Physiology;Population;preservation;primary outcome;programs;prospective;Public Health Schools;pulmonary symptom;Quality of life;Questionnaires;Radionuclide Imaging;Randomized;Randomized Controlled Clinical Trials;Randomized, Controlled Trials;reduce symptoms;Reflux;Regulation;Research;Research Activity;Research Design;Research Personnel;response;Scholarship;secondary outcome;Secondary to;Specialist;Statistical Data Interpretation;statistical learning;Stomach;stroke victims;Symptom Burden;symptomatic improvement;symptomatology;Symptoms;System;Techniques;Testing;Time;Training;Training Activity;trial comparing;trial design;Tube;Universities;Vegetables;Viscosity;Vulnerable Populations;Work

PROJECT_TITLE: A Novel N-of-1 Randomized, Controlled, Clinical Trial to Assess the Effect of Blenderized Tube Feeds on Esophagogastric Physiology

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK(M1)-1-C]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Dental, Oral, and Craniofacial Disease;Disability Research;Headaches;Health Services;Mental Health;Migraine;Neurosciences;Pain Research;Pediatric;Primary Health Care

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Project Narrative In the United States, over 6 million children and adolescents suffer from migraine headaches and it is 1 of the 5 most prevalent childhood disorders. Mind and body approaches can significantly help these youth, but getting access to this type of treatment is a challenge for families. Our mind and body clinical trial study will test a treatment, called “Mind Body Balance for Migraine”, that occurs during a regular medical visit and has registered nurses introducing four coping skills (breathing activity, progressive relaxation, guided imagery, biofeedback) to youth ages 10 to 17 that have migraines.

PI_NAMEs: POWERS, SCOTT W (contact)

PROGRAM_OFFICER_NAME: JEAN-FRANCOIS, BEDA

PROJECT_TERMS: Adherence;Adolescent;Age;Anxiety;Biofeedback;Breathing;care delivery;Caring;Child;Childhood;chronic pain;Clinical;Clinical Trials;Complex;Coping Skills;design;Diagnosis;diaries;disability;Disabling;Disease;Dose;Dropout;Educational process of instructing;effective therapy;effectiveness trial;eHealth;Enrollment;Equilibrium;exceptional responders;experience;experimental group;experimental study;Family;Feasibility Studies;follow-up;functional disability;Guided imagery;Headache;Health Personnel;Home;Hour;Imagery;improved;improved outcome;innovation;interest;Intervention;intervention delivery;intervention refinement;Learning;Measures;Medical;meetings;Mental Depression;Methodology;Migraine;Migraine disability;mind/body;Modeling;multiphase optimization strategy;Muscle relaxation phase;National Center for Complementary and Integrative Health;Nervous System Disorder;Nonpharmacologic Therapy;Nurses;Nursing Staff;Outcome;Outpatients;Participant;Patient Education;Patients;Pediatric Nursing;Pilot Projects;pragmatic trial;Prevention;primary care provider;progressive relaxation therapy;Protocols documentation;Provider;psychologic;Psychologist;Registered nurse;Reporting;Research;Research Design;resource guides;Resources;Respiratory Diaphragm;Safety;secondary endpoint;Site;skills;skills training;Sleep;Specialist;standard care;Telephone;Testing;Time;Training;training project;Travel;treatment duration;treatment optimization;United States;Visit;Youth

PROJECT_TITLE: Mind Body Balance for Pediatric Migraine


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Mental Health;Neurodegenerative;Neurosciences;Palliative Care;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Sleep Research;Social Determinants of Health

ORG_CITY: IRVINE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE The proposed study will test a 3-month, community health worker (CHW) delivered home visit, culturally and language-appropriate intervention for ethnic and underserved dementia family caregivers of persons with dementia (PWD) using wearable technology for real time monitoring of caregivers' stress and sleep. The CHW delivered home visit intervention includes stress reduction techniques by mindful deep breathing and compassionate support/listening and caregiving education to improve caregiver's health, wellbeing, and positive interactions with the PWD. This dementia caregiver study using wearable technology has the potential to significantly lessen health disparities in dementia care, assisting underserved ethnic dementia caregivers in self-management and increasing their quality of life.

PI_NAMEs: LEE, JUNG-AH  (contact);RAHMANI, AMIR

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Adult;Alzheimer's Disease;American;Asian;attentional control;Behavior;Behavior monitoring;biological adaptation to stress;Breathing;California;care giving burden;Caregiver Burden;caregiver interventions;caregiver stress;Caregivers;caregiving;Caring;Cause of Death;Cellular Phone;Chronic stress;Cognitive Therapy;Communication;Community Health Aides;Data;Dementia;dementia care;Dementia caregivers;dementia caregiving;Disease;Education;effective therapy;ethnic minority;Ethnic Origin;experience;Family;Family Caregiver;Family Relationship;Health;health disparity;health related quality of life;Health Services Accessibility;heart rate variability;Home;Home visitation;improved;Individual;innovation;Internet of Things;Intervention;Knowledge;Koreans;Language;Latino;Latino Population;Measures;Mental Depression;Mental Health;Methods;mindfulness;Minority;Modeling;Monitor;Morbidity - disease rate;mortality;multi-component intervention;Not Hispanic or Latino;Outcome;Perception;Personal Satisfaction;Persons;Physical activity;physical conditioning;physical impairment;Physiologic Monitoring;Physiological;Population;positive emotional state;psychoeducation;psychologic;Quality of life;Randomized, Controlled Trials;real time monitoring;Reporting;Research;Resources;response;Responsible Person;Risk Factors;Self Efficacy;Self Management;skills;Sleep;Sleep Disorders;sleep quality;smart watch;Social support;Spouses;Stress;stress management;stress reduction;Techniques;Technology;Telephone;Testing;Time;treatment as usual;underserved minority;Underserved Population;United States Public Health Service;Vietnamese;wearable device;wearable health device;Woman

PROJECT_TITLE: A home-based, culturally and language specific intervention for dementia family caregivers: stress reduction and education with wearable technology for health

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: The canonical role of caspase-9 is to mediate apoptosis. We have discovered a new pathway in which caspase- 9 mediates necrosis. Our in vivo data suggest that this pathway is important in cardiomyocyte death during myocardial infarction with reperfusion. This project delineates key aspects of the pathway and investigates whether its therapeutic inhibition could provide the basis for a new therapy to limit cardiac damage during myocardial infarction.

PI_NAMEs: KITSIS, RICHARD N (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Adult;Apoptosis;Apoptotic;apoptotic protease-activating factor 1;ATP2A2;Attenuated;Cardiac;Cardiac Myocytes;CASP3 gene;CASP9 gene;Cell Death;Cell Death Induction;Cells;Cessation of life;Complex;Data;Disabling;Drug Kinetics;efficacy testing;Etiology;Event;Generations;Genetic study;Goals;Heart;heart damage;Heart failure;heart failure with reduced ejection fraction;heart function;in vivo;Infarction;Inflammation;inhibitor;Knockout Mice;Knowledge;Link;Maps;Mediating;Molecular;mortality;Mus;mutant;Mutate;Myocardial Infarction;Myocardial Reperfusion;Necrosis;Nodal;novel;novel therapeutic intervention;novel therapeutics;Oxidative Stress;Pathway interactions;Peptides;Permeability;programs;Proteins;Proteomics;rational design;Regulation;Reperfusion Therapy;Resistance;response;Role;SERCA2a;Series;Signal Transduction;Site;Stroke;Syndrome;Testing;Therapeutic;therapy design;Tissues;x-linked inhibitor of apoptosis protein

PROJECT_TITLE: Caspase-9 as a nodal point connecting necrotic and apoptotic cell death in myocardial infarction

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ORG_CITY: CLEVELAND

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Project Narrative The “Rustbelt” Center for AIDS Research (CFAR) joins Case-Western University and the University of Pittsburgh to create a regional center focused on ending the HIV epidemic through expanded and innovative research on curing HIV, differences in men and women’s responses to infection and treatment and the development of strategies to prevent new infections while effectively preventing AIDS.

PI_NAMEs: HILLIER, SHARON L.;KARN, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Africa South of the Sahara;AIDS prevention;Area;base;Basic Science;Bioinformatics;Biological Assay;biological sex;Biostatistics Core;career;Clinical;Clinical Investigator;Clinical Research;Clinical Sciences;Clinical Trials;Clinical Virology;cohort;Collaborations;Communities;community engagement;Community Outreach;comorbidity;County;design;Development;Direct Costs;Education;Epidemic;epidemic preparedness;Ethical Issues;experience;Faculty;faculty support;Foundations;Funding;Gender;Grant;HIV;HIV drug resistance;HIV Infections;HIV/AIDS;Income;Infection;innovation;Institution;interdisciplinary collaboration;International;Investments;Joints;Laboratories;Leadership;Link;member;men;Mentors;Monitor;multidisciplinary;next generation;novel strategies;Participant;Pathogenesis;Pilot Projects;Positioning Attribute;prevent;Prevention;Prevention Research;Prevention trial;Process;programs;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;research study;response;Role;Scientific Advances and Accomplishments;Services;sex;Site;Specimen;Strategic Planning;synergism;Systems Biology;Teacher Professional Development;Technology;Tissue Microarray;Training;Translating;Translational Research;treatment trial;Uganda;United States National Institutes of Health;Universities;University Hospitals;vaccine trial;Viral Pathogenesis;virology;Woman;Work;working group

PROJECT_TITLE: Rustbelt Center for AIDS Research (Case/UHC-Pitt CFAR)


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: KARN, JONATHAN  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Africa South of the Sahara;Area;Automobile Driving;Award;Bioinformatics;Biological Assay;Biometry;Budgets;Charge;Cities;Clinical;Clinical Investigator;Collaborations;Communication;Communities;Community Outreach;Consultations;cost efficient;County;design;Development;Direct Costs;Education and Outreach;Educational workshop;Electronic Mail;Ensure;Epidemic;Equilibrium;Equity;experience;Faculty;Faculty Recruitment;Feedback;Funding;Funding Agency;Gender;Genes;Grant;HIV;HIV/AIDS;Immunologics;Immunology;improved;Income;innovation;Institution;inter-institutional;Investments;Joints;Laboratories;Leadership;meetings;member;Mentors;Mentorship;Mission;Molecular;new technology;Newsletter;next generation;organizational structure;outreach program;Process;programs;Public Health;recruit;Research;Research Activity;Research Personnel;Resources;Scientific Advances and Accomplishments;Scientist;Services;sex;Site;Strategic Planning;Study Section;System;tool;Training;Training Activity;Uganda;United States National Institutes of Health;Universities;Update;viral resistance;web site;Work;working group

PROJECT_TITLE: Core A: Administrative


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Maternal Health;Maternal Morbidity and Mortality;Mental Health;Opioid Misuse and Addiction;Opioids;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse;Women's Health Research

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: PROJECT NARRATIVE Most newborns experiencing Neonatal Abstinence Syndrome (NAS) require non-pharmacologic care, which entails, most importantly, maternal involvement with her newborn. To facilitate positive maternal-newborn interactions, mothers need to learn effective caregiving NAS strategies while they are pregnant, yet, an enormous gap exists in the early education of mothers on the symptoms and progression of NAS, in part because no interventions exist to prepare future mothers for the challenges of caring for their newborns at risk for NAS. In this project, I propose to adapt an existing mobile NAS tool for high-risk pregnant women and assess its usability, acceptability, and feasibility in a small randomized controlled analog trial, and engage in career development and training activities that will enhance my expertise in the development, implementation, and testing of interventions for substance using perinatal women.

PI_NAMEs: BURDULI, EKATERINA  (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: Address;Admission activity;Affect;American College of Obstetricians and Gynecologists;analog;Anxiety;arm;Birth;Body Weight decreased;Breast Feeding;care providers;career;career development;caregiver education;Caregivers;caregiving;Caring;Child;clinical trial implementation;Consultations;Cues;Data;design;Development;Discipline of obstetrics;drug relapse;Eating;Education;efficacy testing;Environment;Epidemiology;evidence base;experience;feeding;Feeling;Fever;follow-up;Future;General Population;Goals;Health;Health Technology;high risk;high risk population;High Risk Woman;high standard;hospital readmission;Hospitals;illicit opioid;improved;Industry;Industry Collaboration;Infant Care;innovation;Instruction;interactive tool;Intervention;Interview;Learning;Learning Module;Length;Length of Stay;Maternal Health;maternal risk;maternal safety;Mental Depression;Mentored Research Scientist Development Award;Mentors;Mentorship;mHealth;mhealth interventions;mobile computing;Modeling;Modification;Mothers;National Institute of Drug Abuse;Neonatal Abstinence Syndrome;neonatal health;Neonatal Intensive Care Units;Neonatology;Newborn Infant;Nonpharmacologic Therapy;obstetric care;opioid agonist therapy;opioid treatment program;opioid use;opioid use disorder;opioid withdrawal;Outcome;Perception;perinatal women;pharmacologic;Pilot Projects;poor health outcome;Positioning Attribute;Postpartum Depression;Postpartum Period;Postpartum Women;Pregnancy;pregnant;Pregnant Women;prescription opioid;prevent;product development;programs;Provider;Randomized;Readiness;readmission rates;Recommendation;Recovery;Relapse;Research;Research Personnel;Research Support;Risk;Risk Reduction;Shapes;skills;skills training;Sleep;Stress;Structure;substance use;Substance Use Disorder;sucking;Surveys;Sweating;Symptoms;technology platform;Testing;tool;Training;Training Activity;treatment adherence;treatment arm;treatment as usual;Tremor;usability;virtual;Woman;Work

PROJECT_TITLE: Effective Caregiving for Neonatal Abstinence Syndrome: Development of an Instructional Mobile Technology Platform for High-Risk Pregnant Women


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: LEVINE, ALAN DAVID (contact)

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;African American;Applications Grants;Award;career;career development;Clinical;Clinical Sciences;Collaborations;Communicable Diseases;Communities;Consultations;Development;Developmental Biology;diversity and inclusion;Doctor of Philosophy;Educational workshop;Ethics;Exhibits;experience;Faculty;Fostering;Funding;Future;graduate student;Grant;Grant Review;Growth;HIV;HIV/AIDS;Human Resources;Informed Consent;innovation;Institution;inter-institutional;International;Investments;Leadership;medical schools;Medicine;member;Mental Health;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Microbiology;Minority;Molecular Biology;Molecular Virology;multidisciplinary;next generation;outreach;Participant;participant retention;Patient Recruitments;peer;peer coaching;Postdoctoral Fellow;Procedures;Productivity;professor;Program Reviews;programs;Reproducibility;Research;Research Activity;research and development;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Training;Resources;retention rate;Role;Science;Scientist;senior faculty;Series;Services;Site;social stigma;sound;Structure;success;synergism;System;Systems Biology;Teacher Professional Development;tool;Training;Training Activity;Training Programs;Underrepresented Minority;United States National Institutes of Health;Universities

PROJECT_TITLE: Core B: Developmental


NIH_SPENDING_CATS: Aging;Antimicrobial Resistance;Behavioral and Social Science;Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Substance Misuse

PI_NAMEs: NANKYA, IMMACULATE LILLIAN (contact)

PROJECT_TERMS: Accreditation;Achievement;Acquired Immunodeficiency Syndrome;Address;Affect;Africa;AIDS clinical trial group;AIDS prevention;AIDS related cancer;American;Biological Assay;Blood;Cardiovascular system;Certification;Clinical;Clinical Immunology;clinical investigation;Clinical Research;Clinical Trials Unit;co-infection;Cohort Studies;Collaborations;college;comorbidity;Complement;Complication;Contraceptive methods;cost effective;Doctor of Philosophy;doctoral student;Drug resistance;Dryness;Equipment;experience;Fogarty International Center;Funding;Gender;genome sequencing;Genotype;graduate student;Health Professional;HIV;HIV drug resistance;HIV Infections;HIV/AIDS;HIV/TB;Hormonal;Hospitals;Human Resources;immunological intervention;Immunologics;Immunology;implementation research;improved;innovation;integration site;International;International Cooperation;Investigational Drugs;Investments;Joints;Laboratories;latent HIV reservoir;Lead;Measurement;Measures;men;Microbiology;microbiome;Modeling;Modernization;Molecular;Molecular Virology;Monitor;next generation sequencing;Observational Study;Pathogenesis;Pathologist;Patients;Phenotype;pre-clinical;pre-exposure prophylaxis;Prevention Research;programs;Research;Research Personnel;research study;Research Support;RNA;Role;Science;Scientist;sex;Site;Spottings;Students;Techniques;Technology;Technology Transfer;Testing;Training;training opportunity;Translational Research;translational study;Treatment Failure;Uganda;Universities;Vertical Transmission;virology;Virus Integration;whole genome;Woman

PROJECT_TITLE: Core C:  Uganda


PI_NAMEs: JACOBSON, JEFFREY M. (contact)

PROJECT_TERMS: 2019-nCoV;Acquired Immunodeficiency Syndrome;Address;AIDS clinical trial group;AIDS prevention;American;Ancillary Study;Area;Award;Biological;Biological Specimen Banks;Biometry;Biostatistics Core;Bronchoalveolar Lavage Fluid;Caring;Cerebrospinal Fluid;Cervical;cis-female;Clinical;Clinical Data;Clinical Investigator;Clinical Research;Clinical Sciences;Clinical Services;co-infection;cohort;Cohort Studies;Collaborations;Communities;community advisory board;Data;data repository;Databases;design;Development;Enrollment;Ensure;Epidemic;experience;Feces;Fostering;gastrointestinal;Gender Issues;genital secretion;Genitalia;Goals;Grant;Hepatitis C virus;HIV;HIV/AIDS;Human;Human Subject Research;implementation science;Individual;infection risk;Institution;Institutional Review Boards;interest;International;Laboratories;Link;Lung;meetings;men;Mentors;Mentorship;Mycobacterium tuberculosis;Participant;Pathogenesis;Patient Care;Patients;Pennsylvania;peripheral blood;Persons;Placenta;Population;Populations at Risk;Prevention;Protocols documentation;Provider;Rectum;repository;Research;Research Personnel;Research Project Grants;research study;Resources;Risk;Sampling;service organization;Services;sex;Site;Specimen;substance use;Substance Use Disorder;success;System;Systems Biology;Tissues;Training and Education;transgender women;Translational Research;translational scientist;translational study;Uganda;Umbilical Cord Blood;United States National Institutes of Health;Universities;Viral Pathogenesis;Work;working group

PROJECT_TITLE: Core D:  Clinical Sciences


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: TILTON, JOHN CHRISTIAN (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;AIDS prevention;Antibodies;Applied Research;Autologous;Automation;base;Basic Science;Biological Assay;Biological Models;Biometry;Cell Line;Cell model;Cells;Characteristics;Clinical Sciences;Clinical Virology;Clonality;Collaborations;Complement;Data;Dedications;design;Detection;detection assay;Diagnostic;DNA;efficacy evaluation;Epidemic;experience;Funding;Genetic Transcription;Genomics;Genotype;high resolution imaging;HIV;HIV drug resistance;HIV-1;Human;imaging platform;Immunology;improved;Incidence;Individual;Infection;innovation;instrument;instrumentation;integration site;Laboratories;Length;live cell imaging;Measures;Methods;microbicide;Microscopy;Modeling;Modernization;Molecular;Monitor;new technology;novel;novel strategies;Pathogenesis;Pattern;Performance;Pharmaceutical Preparations;Phenotype;Phylogenetic Analysis;Plasma;Population;Predisposition;prevent;Prevention;programs;protein expression;Proteomics;Reagent;receptor;Recording of previous events;Research;Research Personnel;Resolution;Resources;RNA;Sampling;Services;single cell technology;Site;System;Systems Biology;Techniques;Technology;Testing;Therapeutic Intervention;Time;tool;Training;Training and Education;Transcript;transcriptomics;transmission process;Tropism;Uganda;United States National Institutes of Health;Variant;Viral;Viral Pathogenesis;Virion;virology;Virus;Virus Integration;Work

PROJECT_TITLE: Core E:  Viral Pathogenesis & Persistence