NIH_SPENDING_CATS: Aging;Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Disability Research;Hearing Loss;Neurosciences;Prevention;Rehabilitation;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: Project Narrative: Effective speech communication plays an important role in shaping positive health outcomes and improving overall well-being, particularly for older adults with hearing loss. This project investigates the social networks of adults with hearing loss who obtain cochlear implants, and how and why social networks support effective speech communication in this population. Because social networks represent important and potentially malleable factors, knowledge gained from this project could lead to the development of novel interventions aimed at enhancing communication ability in adults with hearing loss and cochlear implants.

PI_NAMEs: TAMATI, TERRIN NICHOLE (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Adult;Age;age effect;Aging;Clinical;Cochlear Implants;Cognitive;Communication;Compensation;design;Development;experience;Gender;Goals;Health;Health behavior;Hearing;hearing impairment;hearing restoration;human old age (65+);implantation;improved;Individual;Individual Differences;insight;Intervention;Intervention Studies;Knowledge;Lead;Linguistics;Link;Measures;middle age;normal hearing;novel;older adult;Operative Surgical Procedures;Outcome;Partner Communications;peer;Performance;Personal Satisfaction;Play;Population;Process;Quality of life;Research;Risk;Role;Sensorineural Hearing Loss;sex;Shapes;social;social communication;social engagement;social factors;Social Network;social network intervention;social relationships;Social support;sound;Speech;speech recognition;Structure;System;Time;Translational Research;Withdrawal

PROJECT_TITLE: Social Networks for Optimizing Communication Ability in Adult Cochlear Implant Users

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-L (A1)]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Disabling falls are a common feature of advancing Parkinson disease (PD). There are no markedly effective treatments to reduce fall risk in mid-stage PD. Prior studies indicate that brain deficits of the chemical messenger acetylcholine underlie increased fall risk. We will evaluate a commonly used drug, varenicline, that partially mimics acetylcholine, to determine if varenicline treatment improves multitasking and reduces fall risk.

PI_NAMEs: ALBIN, ROGER L;KOTAGAL, VIKAS  (contact)

PROGRAM_OFFICER_NAME: BARNES, JENNIFER HAMILTON

PROJECT_TERMS: Acetylcholine;Address;Agonist;Attention;Base Ratios;Biological;Biostatistical Methods;Blinded;Brain;Caregivers;Central Nervous System;Chantix;Chemicals;cholinergic;Cholinergic Receptors;Cholinesterase Inhibitors;Clinical;Clinical Research;Clinical Trials;Clinical Trials Design;clinically relevant;Cognitive;Cognitive deficits;cost;Cross-Over Studies;Data;dementia risk;Disabling;Dose;Double-Blind Method;Drug usage;effective therapy;efficacy trial;Enrollment;equilibration disorder;experience;Experimental Models;experimental study;fall injury;Fall prevention;fall risk;falls;FDA approved;Fracture;Frequencies;functional disability;Functional disorder;Future;Gait;Gait abnormality;gait examination;Goals;high risk;Hospitalization;Impaired cognition;Impairment;improved;in vivo;Institutionalization;Intervention;Intervention Trial;Knowledge;Link;Masks;Methods;mild cognitive impairment;Modeling;mortality;multitask;Nicotinic Agonists;Nicotinic Receptors;novel;Outcome;Outcome Measure;Parkinson Disease;Participant;Performance;Persons;Pharmaceutical Preparations;pharmacologic;Phase;phase II trial;Physical therapy;Physiological;Placebos;Positron-Emission Tomography;Posture;pre-clinical research;Prevention trial;primary endpoint;primary outcome;prospective test;Provider;Publishing;Randomized;randomized trial;receptor;Relative Risks;Research Personnel;Risk;risk mitigation;secondary endpoint;Site;Specificity;System;Task Performances;Testing;Therapeutic;therapeutic development;Time;trait;trial enrollment;varenicline;Walking

PROJECT_TITLE: Reducing falls with Varenicline in Hypocholinergic Parkinson disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-G (65)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: SAN ANTONIO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Calcium dysregulation occurs in many cell types during Alzheimer’s disease, particularly around amyloid plaques. The goal of the proposed research is to examine L-type voltage calcium channel antagonists as neuroprotective agents that target both endo-lysosomal dysfunction and microglia dysregulation in Alzheimer’s disease.

PI_NAMEs: HOPP, SARAH CHRISTINE (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Acting Out;age related;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amlodipine;Amyloid;Amyloid beta-Protein;amyloid pathology;antagonist;Autophagosome;behavioral outcome;beta-site APP cleaving enzyme 1;Brain;Ca(2+)-Calmodulin Dependent Protein Kinase;Calcium;Calcium Channel;cell type;Chronic;Clinical Trials;Cognitive deficits;conditional knockout;Copy Number Polymorphism;cytokine;Data;dementia risk;Dihydropyridines;Dose;Drug Exposure;Epidemiology;Fibroblasts;Functional disorder;functional improvement;Future;Gene Expression Regulation;Genes;Genetic Polymorphism;Goals;Human;hyperphosphorylated tau;Impaired cognition;In Vitro;Inflammatory;Isradipine;knock-down;Knockout Mice;L-Type Calcium Channels;Link;Lysosomes;Mediating;Mediator;Membrane Proteins;Memory impairment;Microglia;mouse model;Mus;Neurites;Neurodegenerative Disorders;neuroinflammation;Neurons;neuropathology;neuroprotection;Neuroprotective Agents;Nimodipine;Pathology;Pathway interactions;Patients;Peripheral;Phenotype;Phosphorylation;pre-clinical;Production;Publishing;Regulation;Research;Role;Senile Plaques;Source;targeted agent;tau Proteins;Testing;trend;voltage;Work

PROJECT_TITLE: L-type calcium channels in Alzheimer’s disease pathophysiology

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW ORLEANS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Chlamydia trachomatis (Ct) is a common treatable sexually transmitted infection that can result in important morbidity and, despite decades of clinic-based screening, cases continue to increase - disproportionately affecting Black youth. Check It is a community-based, bundled, seek-test-and-treat Ct intervention originally designed for men who have vaginal sex and was impactful in reducing Ct rates among women. To expand its potential impact, we will adapt it to examine the inclusion of women, impact of the change in treatment guidelines, impact of home specimen collection, effect of incentivized peer referral, utility of HIV/syphilis testing, and feasibility of extra-genital self-collected swabs, as well as program efficacy and cost- effectiveness.

PI_NAMEs: KISSINGER, PATRICIA J (contact)

PROGRAM_OFFICER_NAME: CHUANG, ELEANORE JENNIFER

PROJECT_TERMS: Adherence;Affect;Age;Age Years;black men;Black race;black women;Centers for Disease Control and Prevention (U.S.);Chlamydia;Chlamydia trachomatis;Clinic;Collaborations;Collection;Communities;community partners;cost;Cost Analysis;cost effective;cost effectiveness;Data;Deep South;design;Disease;Disparity;disparity reduction;Doxycycline;Ectopic Pregnancy;efficacy evaluation;Enrollment;Evaluation;experience;genital infection;Genitalia;girls;Goals;health disparity;Heterosexuals;HIV;Home;Human immunodeficiency virus test;improved;Incentives;indexing;Infection;Infertility;Interruption;Intervention;Learning;logarithm;Medicaid;Medical;Medical Care Costs;men;Methods;Modeling;Morbidity - disease rate;Motion;National Institute of Allergy and Infectious Disease;National Institute of Child Health and Human Development;Notification;Participant;Patients;peer;Pelvic Inflammatory Disease;Pharmaceutical Preparations;Population;population based;pre-exposure prophylaxis;Prevention;Prevention program;Prevention strategy;program costs;programs;Quality-Adjusted Life Years;racial disparity;Recommendation;recruit;routine screening;sample collection;screening;screening guidelines;screening program;sex;sexually active;Sexually Transmitted Diseases;Site;Specimen;Structural Racism;study population;Swab;Syphilis;Syphilis Serodiagnosis;Testing;Time Series Analysis;time use;treatment guidelines;United States;Vaccines;Vagina;Woman;young woman;Youth

PROJECT_TITLE: A seek, test, and treat intervention to reduce Chlamydia trachomatis disparities in Black youth living in the deep South

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: PORTLAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Hypertension and heart failure are characterized by increased cardiac sympathetic transmission, and sympathetic hyperactivity can trigger lethal arrhythmias. The goal of our research is to elucidate the mechanisms that underlie enhanced peripheral sympathetic transmission to the heart in cardiovascular disease. This will lay the groundwork for new therapeutic options that target the nervous system to decrease arrhythmia risk and prevent sudden cardiac death.

PI_NAMEs: HABECKER, BETH A (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Acetylcholine;Address;Adrenergic beta-Antagonists;Angiotensin II;Animal Model;Arrhythmia;autonomic nerve;blood pressure elevation;Calcium;Cardiac;Cardiovascular Diseases;Cause of Death;Cells;Central Nervous System;cholinergic;Coupled;Coupling;Data;Development;Devices;Disease;Electrophysiology (science);experimental study;Functional disorder;Future;Ganglia;Ganglionectomy;Gap Junctions;Genetic;Goals;Health;Heart;Heart Diseases;Heart failure;heart function;Human;Hyperactivity;Hypertension;Image;in vivo;insight;Intervention;Knockout Mice;Life;Mediating;mouse model;nerve injury;Nervous System;neurochemistry;Neuroglia;Neuronal Plasticity;Neurons;neuroregulation;Neurotransmitters;new therapeutic target;noradrenergic;novel;novel therapeutics;patch clamp;Pathologic;Pathology;Patients;Peripheral;Pharmacology;prevent;Research;response;Risk;Role;Signal Transduction;Structure of stellate ganglion;sudden cardiac death;Sympathetic Ganglia;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Tissues;tool;Transgenic Organisms;translational study;transmission process;United States;Ventricular Arrhythmia;Vesicle;Wild Type Mouse;Work

PROJECT_TITLE: Peripheral Sympathetic Dysfunction in Cardiac Disease

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: CA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: Los Angeles

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Public Health Relevancy Statement The proposed research is meant to provide physicians with an entirely new nano-based imaging technology that has the potential to determine the immune profile of an individual patient’s tissue in a single image. Clinicians will be able to utilize the new imaging strategy to interrogate a multitude of immune biomarkers on the same tissue sections prepared for histology. Incorporating it into the pathology workflow could enable physicians to better understand the patient’s molecular profile and stratify patients to receive the most effective therapeutic regimen possible.

PI_NAMEs: MALLICK, PARAG KUMAR;ZAVALETA, CRISTINA L. (contact)

PROGRAM_OFFICER_NAME: WU, YICONG

PROJECT_TERMS: Acceleration;Affinity;antibody conjugate;application programming interface;Autoimmune Diseases;Bar Codes;Binding;Biological Markers;cancer therapy;CD3 Antigens;Cell Culture Techniques;cell type;Cells;Charge;chemical conjugate;chemical property;Classification;Clinical;clinical application;clinical translation;clinically relevant;cohort;Collection;Communicable Diseases;computerized tools;Consumption;contrast imaging;Contrast Media;Data;density;design;Development;Diagnostic Procedure;diagnostic strategy;Disease;Effectiveness;effectiveness testing;Environment;fabrication;Failure;Flow Cytometry;Future;Generations;Goals;Health Care Costs;histological specimens;Histology;Human;Human Cell Line;human tissue;Image;imaging approach;imaging capabilities;Imaging Device;imaging platform;Imaging Techniques;Imaging technology;Immune;Immune system;Immune Targeting;Immunohistochemistry;Immunologic Markers;Immunologic Receptors;Immunotherapy;improved;individual patient;ineffective therapies;innovation;Ligands;Location;Machine Learning;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Measurement;Microscopic;Molecular;molecular imaging;molecular marker;molecular pathology;Molecular Profiling;Monoclonal Antibodies;Morbidity - disease rate;MS4A1 gene;multiplexed imaging;nano;nanoparticle;Neighborhoods;Nervous System Disorder;new technology;novel;Oncologist;optical imaging;Outcome;Pathologist;Pathology;pathology imaging;patient stratification;Patient-Focused Outcomes;Patients;Pattern;personalized medicine;Phenotype;Physicians;Play;Population;Prediction of Response to Therapy;predictive tools;prognostic;prognostic tool;Property;Proteins;Proteomics;Public Health;Pythons;Raman Spectrum Analysis;Readability;Regimen;Research;Resolution;responders and non-responders;response;Sampling;side effect;Specificity;Specimen;spectrograph;Stains;Surface;survival prediction;Testing;therapeutically effective;Time;Tissue Sample;Tissues;tool;treatment response;trend;tumor;tumor heterogeneity;tumor microenvironment;Tumor Tissue;wound healing

PROJECT_TITLE: Development of a New Multiplexed Imaging Strategy for Immunoprofiling using Raman-Active Nanoparticles

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-U (55)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Data Science

ORG_CITY: MINNEAPOLIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative A core mission of the Population and Social Processes Branch of NIA is developing infrastructure for international and comparative research to further our understanding of how different social, familial, environmental, geographic, cultural, and institutional contexts influence the aging process. The proposed database directly addresses these goals by providing a resource of unprecedented power for understanding the effects of public policies, social institutions, and environmental conditions on the health, well-being, and functioning of people over the life course and in their later years across the developing world.

PI_NAMEs: CLEVELAND, LARA L;RUGGLES, STEVE  (contact);SOBEK, MATTHEW

PROGRAM_OFFICER_NAME: BRAUDT, DAVID BRUCE

PROJECT_TERMS: Address;Africa;aged;Aging;aging population;aging process;Asia;Big Data;Censuses;Characteristics;Collaborations;Collection;Communities;comparative;computerized data processing;Consensual Unions;cost effective;Data;data acquisition;data cleaning;data dissemination;data harmonization;data infrastructure;data ingestion;Databases;Demographic Survey;Developed Countries;Developing Countries;Development;disability;Disease;Economics;Education;Educational workshop;Europe;Fertility;Floor;Funding;Geographic Locations;Geography;Goals;Growth;Health;Household;Housing;human old age (65+);improved;Individual;Infrastructure;innovation;Institution;interest;Intergenerational Relations;International;Investments;Latin America;Life Cycle Stages;literacy;Longitudinal Surveys;Marital Status;Metadata;migration;Mission;mortality;North America;Older Population;outreach;Personal Satisfaction;Persons;Policy Making;Population;Population Process;preservation;Process;Public Policy;Publications;Recording of previous events;Reproductive Health;Request for Proposals;Research;Research Infrastructure;Research Personnel;residence;Resources;Retirement;Risk;Role;Running;Sampling;Series;Sewage;social;Social Processes;Source;Surveys;System;tool;Training;United Nations;Water Supply;Work

PROJECT_TITLE: Microdata for Research on Aging in the Global South

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Machine Learning and Artificial Intelligence;Natural Products;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHAMPAIGN

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: PROJECT NARRATIVE The majority of existing drugs are natural products or derivatives thereof. However, the rate of discovering new natural products has diminished despite an increased need for new drugs, especially antibiotics. The proposed work will develop a bioinformatics-, artificial intelligence/machine learning-, and robotics-enabled synthetic biology platform for discovery and characterization of new antibiotics.

PI_NAMEs: MITCHELL, DOUGLAS ALAN;VAN DER DONK, WILFRED A.;ZHAO, HUIMIN  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Address;algorithm development;Algorithms;Analytical Chemistry;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;antimicrobial;Artificial Intelligence;artificial intelligence algorithm;Bacillus subtilis;Binding Sites;bioactive natural products;Bioinformatics;bioinformatics tool;Biological Assay;Burkholderia;C-terminal;Capital;Cells;Chemicals;Cloning;Communities;deep sequencing;design;Development;Directed Molecular Evolution;Disparate;DNA;Drug Industry;Engineering;Enzymes;Escherichia coli;ESKAPE pathogens;Evaluation;Event;Family;Genes;Genome;Genomics;Genotype;Goals;guided inquiry;improved;in silico;Infection;Infrastructure;innovation;interest;Klebsiella;Klebsiella pneumoniae;Knowledge;large language model;Libraries;Machine Learning;Metabolic Pathway;Methods;Modification;N-terminal;Natural Product Drug;Natural Products;Neighborhoods;next generation;novel;novel therapeutics;Outcome;pathogenic bacteria;Pathway interactions;Pattern;Peptides;Periodicity;pharmacologic;Plasmids;Positioning Attribute;Post-Translational Protein Processing;predictive tools;Probability;Procedures;Process;Production;Productivity;Research Personnel;Resistance;resistance gene;Ribosomes;Robotics;S-Adenosylhomocysteine;S-Adenosylmethionine;scaffold;Scanning;Series;Source;Structure;success;synthetic biology;System;Techniques;Technology;tool;training data;Validation;Work

PROJECT_TITLE: A Next-Generation Scalable Platform to Discover Antimicrobials of Ribosomal Origin

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Pediatric;Primary Immunodeficiencies;Rare Diseases;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_DEPT: PEDIATRICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Undiagnosed diseases in children and adults represent frustrating and costly challenges for patients, families, physicians, and society. This proposal would support the Washington University in St. Louis UDN Diagnostic Center of Excellence to continue to recruit, select, evaluate, and follow participants with disorders in any clinical specialty, adult and pediatric, provide comprehensive clinical evaluations, and participate in all UDN protocols, data management and sharing, and sustainability planning.

PI_NAMEs: DICKSON, PATRICIA I (contact)

PROGRAM_OFFICER_NAME: DOSS, ARGENIA LANISHA NECOLE

PROJECT_TERMS: Academic Medical Centers;Adult;Agreement;Appointment;Area;Basic Science;Biological Assay;Biological Models;Biomedical Research;Biometry;Budgets;Chairperson;Child;Childhood;Clinical;clinical center;clinical diagnostics;Clinical Research;clinical research site;cohort;Collaborations;community engaged approach;community engagement;Community Outreach;congenital immunodeficiency;Cortical Malformation;cost;Cost Sharing;County;Data;Data Coordinating Center;data management;Data Science;data sharing;Dedications;design;Diagnosis;Diagnostic;diagnostic value;Disease;Disease Management;Enrollment;Epilepsy;Equity;Evaluation;experience;Expert Systems;Faculty;Family;Federally Qualified Health Center;follow-up;Foundations;Frustration;Funding;Generations;Genes;Genetic;genetic counselor;Genomics;Health;health care service organization;Health Insurance;health literacy;Health Personnel;Health Promotion;Healthcare;Hospitals;imaging study;Immune System Diseases;Improve Access;improved;Individual;Informatics;Infrastructure;Inherited;Institution;Insurance;International;Laboratories;Laboratory Study;Leadership;Letters;low socioeconomic status;Lung Diseases;Medical;medical specialties;Medicine;member;Methods;Minority Groups;model organism;Modeling;Mosaicism;Names;Natural Language Processing;Neonatology;Nervous System Disorder;Neurodevelopmental Disorder;Neurology;neuromuscular;Neuromuscular Diseases;novel;Outpatients;outreach;outreach program;Participant;Patients;payment;pediatric department;Pediatric Research;Phase;Phenotype;Physicians;Population;Process;programs;Progress Reports;Protocols documentation;Pulmonology;Rare Diseases;recruit;research clinical testing;Research Support;Rheumatology;safety net;Scientist;screening;Site;Societies;Source;success;System;Testing;Toxicology;Translational Research;Underrepresented Minority;underserved community;Underserved Population;Uninsured Medical Expense;United States National Institutes of Health;Universities;Variant;Washington;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-W (21)]


NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Dietary Supplements;Digestive Diseases;Infectious Diseases;Maternal Health;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative  The goal of this research project is to understand why group B Streptococcus (GBS), a type of bacteria that causes severe pregnancy complications such as stillbirth and preterm labor, can be harmless in the gut and vagina of healthy adults yet catastrophically dangerous in the amniotic fluid surrounding a fetus. We hypothesize that when GBS moves into the amniotic fluid, it experiences a lack of essential nutrients that are typically present in the digestive and vaginal tracts, and that this nutrient deprivation activates bacterial stress responses. These stress responses may include increased expression of harmful molecules that trigger the maternal and fetal immune system, ultimately causing tissue damage and threatening the pregnancy. These studies may help us better understand and prevent GBS-related pregnancy complications.

PI_NAMEs: HOOVEN, THOMAS A (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Adult;adverse pregnancy outcome;Affect;amniotic cavity;Amniotic Fluid;Animal Pregnancy;Bacteria;bacterial metabolism;biological adaptation to stress;Cells;Cellular biology;Cellular Stress;Characteristics;Chemicals;clinically relevant;cofactor;CRISPR interference;cytotoxicity;Dangerousness;Data;dietary supplements;Disease;Drops;Environment;Epithelium;Event;experience;Exposure to;fetal;Fetal Death;Fetal Membranes;Fetus;gastrointestinal;Gene Expression Profiling;Generations;Genetic;Genitourinary system;Goals;Growth;gut microbiota;Human;Immune;Immune system;in vivo;in vivo Model;Infection;Inflammasome;Inflammation;Inflammatory;Injections;Injury;innovation;insight;Institution;Intestines;intraamniotic infection;Invaded;knock-down;Laboratories;Link;Mediating;Mediator;member;Metabolic;Metabolic Pathway;Metabolic stress;Metabolism;metabolome;metabolomics;microbiota;Micronutrients;migration;Modeling;Molecular;mouse model;multidisciplinary;Mus;neonatal period;Nucleotide Biosynthesis;nucleotide metabolism;Nucleotides;Nutrient;nutrient deprivation;Nutritional;nutritional supplementation;pathobiont;Pathway interactions;pharmacologic;Phenotype;Positioning Attribute;Pregnancy;Pregnancy Complications;Pregnancy loss;Pregnancy Outcome;Pregnant Uterus;Premature Birth;Premature Labor;prevent;Production;Publishing;Research Project Grants;response;Second Messenger Systems;Signal Transduction;Signaling Molecule;small molecule;Starvation;stem;stillbirth;Streptococcal Infections;Streptococcus Group B;Supplementation;System;Testing;Tissue membrane;Tissues;tool;Vagina;Virulence;Virulence Factors;Virulent;Work

PROJECT_TITLE: Signal transduction, metabolic shifts, and host interactions during group B Streptococcus infection

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Atherosclerotic cardiovascular disease (CVD) remains the leading cause of death worldwide. There is great need for integrative multi-omics and machine learning algorithms of histomorphological, cellular, genomic and spatial features of atherosclerotic plaques to implicate novel gene, cell subtype and histomorphological features of lesion vulnerability and CVD risk. This work will advance genome- and mechanism-based therapeutic opportunities for CVD in an era of residual CVD risk despite aggressive LDL-C lowering therapies.

PI_NAMEs: LI, MINGYAO ;MAEGDEFESSEL, LARS ;REILLY, MUREDACH P (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: 8-Oxoguanine DNA Glycosylase;Acceleration;Algorithms;Anatomy;Arterial Fatty Streak;Arteries;Atherosclerosis;Automobile Driving;Base Excision Repairs;biobank;Blood Vessels;c-myc Genes;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;causal variant;Cause of Death;Cell Communication;Cell Lineage;cell type;Cells;Characteristics;Classification;Clinical;clinical practice;clinical predictors;clinically relevant;Coronary;coronary lesion;coronary plaque;Coupled;Custom;Data;design;ethnic diversity;Etiology;Evaluation;Event;feature extraction;follow-up;Gene Expression;gene panel;Genes;Genetic;Genetic Markers;Genome;genome wide association study;Genomics;high risk;Histology;Human;human data;Human Genetics;human model;Image;Immunohistochemistry;insight;Intervention;Lesion;Lipids;Location;Low-Density Lipoproteins;Machine Learning;machine learning algorithm;machine learning model;Maps;Modeling;Molecular;molecular subtypes;mouse genetics;mouse model;multidisciplinary;multiple omics;Mus;novel;overexpression;Pathway interactions;Patients;Pattern;Peripheral;prediction algorithm;Quantitative Trait Loci;Regulator Genes;repair enzyme;Residual state;Resolution;single-cell RNA sequencing;Smooth Muscle Myocytes;spatial integration;success;supervised learning;Testing;Therapeutic;Thinness;Time;transcriptome;transcriptome sequencing;transcriptomics;ultra high resolution;Validation;vascular bed;Work

PROJECT_TITLE: Integration of spatial transcriptomics, genetics, and histomorphology for causal inference in atherosclerotic cardiovascular disease

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: RELEVANCE Mitochondria are intracellular organelles responsible for generating energy, which cellular calcium signals can regulate. Inherited defects in calcium communication to mitochondria lead to neurological and muscle disease. This project aims to understand better how calcium regulates mitochondrial energy metabolism and how various defects in this process contribute to human diseases.

PI_NAMEs: GRABAREK, ZENON  (contact);MOOTHA, VAMSI KRISHNA

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: 3-Methylglutaconic aciduria type 2;Ablation;Alleles;Apoptotic;Binding;Biochemistry;Biological Assay;Calcium;Calcium Channel;Calcium Signaling;calcium uniporter;Cardiac;Cardiolipins;cardiometabolism;Cells;Chemicals;Citric Acid Cycle;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;Complex;Coupled;COVID-19;Data;Defect;Dependence;Disease;Dominant-Negative Mutation;Drug or chemical Tissue Distribution;EF Hand Motifs;Embryo;Energy Metabolism;exercise intolerance;Exhibits;experimental study;Fatigue;follow-up;Funding;Gene Expression;Genes;Genetic;Genetic Screening;Goals;Heterodimerization;Homo;Human;human disease;Human Genome;Hydrogen;Impairment;In Vitro;in vivo;Inbreeding;Inflammasome;Inflammation;Inherited;inhibitor;Inner mitochondrial membrane;insight;Knock-out;Laboratories;Lead;Lipids;loss of function;loss of function mutation;Macrophage;Maps;Membrane;Metabolic;metabolic myopathies;Mitochondria;Mitochondrial Proteins;Molecular;Mus;Muscle;muscle regeneration;Muscular Dystrophies;mutant;Myopathy;Names;Natural Immunity;Nervous System Disorder;Organelles;Oxidoreductase;paralogous gene;Pathology;Pathway interactions;Permeability;Physiology;Process;Production;Protein Isoforms;Proteins;proteoliposomes;Publications;reconstitution;Regulation;Reporting;Resolution;Resources;response;RNA Splicing;Roentgen Rays;Role;Signal Transduction;Single Nucleotide Polymorphism;skeletal;Skeletal Muscle;Structure;System;Technology;Tissues;trait;Update;uptake;Variant;voltage;Work;Yeasts

PROJECT_TITLE: Biochemistry and molecular physiology of the mitochondrial calcium uniporter

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: PROJECT NARRATIVE Venous thromboembolism (VTE) is an increasingly prevalent problem for pediatric, adolescent, and young adult (AYA) cancer patients, which can be partially attributed to off-target effects of chemotherapy treatments that damage the vascular endothelium and create a pro-inflammatory environment. PET/CT imaging with the radionuclide 18F-FDG is standard of care for monitoring treatment responses in many cancers, but could provide additional insight into chemotherapy-induced venous toxicity and risk for VTE events by allowing for quantitative assessment of serial changes in venous inflammation. In this project, we will validate 18F-FDG PET/CT imaging as a non-invasive approach for evaluating chemotherapy-induced venous toxicity and risk for VTE events, thereby laying the foundation for the use of image-derived measures of venous inflammation to enhance personalized plans for thromboprophylaxis and promote improved quality of life for pediatric and AYA cancer patients.

PI_NAMEs: STACY, MITCHEL R (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: Acceleration;Adolescent and Young Adult;Adolescent and young adult cancer patients;Adult;Adult Lymphoma;Anti-Inflammatory Agents;Anticoagulants;Anticoagulation;Antiinflammatory Effect;Biological Markers;Blood Vessels;Cancer Patient;cancer therapy;chemotherapy;Child;Childhood;Clinical;clinical imaging;clinical research site;cohort;deep learning;Deep Vein Thrombosis;Diagnosis;Disease Progression;Dose;Endothelial Cells;Enoxaparin;Environment;Event;Fluorine;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;follow-up;Foundations;Generations;Goals;Guidelines;Harvest;Hemorrhage;Heparin;high risk;Hospitalized Child;Image;Image Analysis;image guided;imaging approach;imaging detection;imaging study;improved;in vivo;Incidence;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;inflammatory milieu;insight;Lymphoma;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;Methods;microPET/CT;Modeling;molecular imaging;Monitor;Morbidity - disease rate;Multi-site clinical study;Nature;non-invasive imaging;Oncologist;Oncology;Oral;Patients;Pediatric cohort;Pediatric Hospitals;PET/CT scan;Physical activity;Positron-Emission Tomography;pre-clinical;prognostic value;prospective;Publishing;Pulmonary Embolism;Quality of life;Radiation therapy;Radioisotopes;real time monitoring;recruit;Research;research clinical testing;response;Risk;Risk Assessment;risk prediction;risk prediction model;Rodent;Rodent Model;Role;routine care;Site;Staging;standard care;standard of care;Testing;Thrombocytopenia;Tissue Sample;Tissues;Toxic effect;treatment response;uptake;Validation;Vascular Endothelium;vascular inflammation;vascular injury;Venous;venous thromboembolism;Work;X-Ray Computed Tomography

PROJECT_TITLE: PET/CT Imaging of Venous Thromboembolism in Pediatric, Adolescent, and Young Adult Oncology

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Genetic variants in myosin heavy chain 7 (MYH7) are common causes of hypertrophic cardiomyopathy (HCM), a potentially life-threatening heart disease. Most of the MYH7 variants are classified as variants of unknown significance, which affects the ability to accurately identify patients at risk for HCM. This proposal will determine the disease-causing potential of thousands of MYH7 variants to better interpret genetic test results for patients and will identify shared mechanisms by which MYH7 variants cause HCM, which may inform potential future interventions.

PI_NAMEs: YANG, KAI-CHUN DANIEL (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Address;Affect;American;autosome;Benign;Biochemical;Biological Assay;Calcium;Cardiac Myocytes;cDNA Library;Cell Line;Cell Size;cell type;Cells;Classification;Clinical;ClinVar;Complementary DNA;CRISPR-mediated transcriptional activation;Data;Desmin;Diagnostic;Disease;emotional distress;Engineering;Ensure;experimental study;Familial Hypertrophic Cardiomyopathy;Future;gene correction;gene-editing approach;Generations;Genes;genetic testing;genetic variant;genome editing;Genomics;Guidelines;Heart Diseases;Heart failure;Heritability;Human Engineering;human induced pluripotent stem cells;Hypertrophic Cardiomyopathy;Hypertrophy;improved;Individual;induced pluripotent stem cell derived cardiomyocytes;interest;Intervention;Knock-in;Left ventricular structure;Libraries;Life;Malignant Neoplasms;Maps;Measures;Medical;Medical Genetics;medical schools;Methods;molecular marker;Morphology;Mutagenesis;mutation screening;Myosin Heavy Chains;Nonmuscle Myosin Type IIA;novel;Pathogenicity;Patients;Phenotype;Physiological;predictive test;Proteins;Recommendation;Resources;Retrieval;Risk;Single Nucleotide Polymorphism;stem cell genes;success;sudden cardiac death;Test Result;Time;Variant;variant of unknown significance

PROJECT_TITLE: Deep mutational scanning of MYH7 in genome-edited cardiomyocytes

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Estrogen;Mental Health;Neurosciences;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Behavioral disorders that have a strong social component, such as autism spectrum disorders, are often more common and severe in males than in females. Sexual differentiation of the brain likely contributes to these differences. This research explores the behavioral consequences of sex differences in neural systems implicated in social behavior.

PI_NAMEs: DE VRIES, GEERT J.;PETRULIS, ARAS T (contact);STERN, JAVIER E

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Adult;Affect;affiliative behavior;Animals;Area;Argipressin;argipressin receptor;autism spectrum disorder;Automobile Driving;Behavior;Behavior Disorders;Behavioral;behavioral response;Biosensor;Brain;brain control;Calcium;Cell Physiology;Cells;Code;cost;Disease;experimental study;Female;Foundations;Functional disorder;Genetic;Grant;Human;Image;in vivo;Incidence;insight;interest;Investigation;knock-down;Knock-out;Laboratories;Lateral;Link;male;Measures;Mediating;Morbidity - disease rate;nerve supply;neural;Neurons;Neuropeptides;Neurotransmitters;optogenetics;Output;pharmacologic;Play;Prevalence;prevent;receptor;Receptor Cell;Receptor Gene;Research;response;Role;Severities;sex;Sex Differences;Sex Differentiation;sex variable;sexual dimorphism;social;Social Behavior;Social Behavior Disorders;Social Controls;social influence;Social Interaction;Societies;Structure;Structure of terminal stria nuclei of preoptic region;Synapses;System;Testing;theories;Time;Vasopressins;Vertebrates

PROJECT_TITLE: Sexually Dimorphic Vasopressin Circuits in the Control of Social Interest

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Clinical Research;Lung;Pulmonary Fibrosis;Pulmonary Hypertension;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Pulmonary hypertension is elevated blood pressure in the pulmonary artery that progressively leads to right heart remodeling, followed by right heart failure and death. We will elucidate regulatory mechanisms and suggest new potential prognostic indicator and therapeutic targets for this detrimental disease.

PI_NAMEs: PANDIT, LAVANNYA M.;PI, XINCHUN  (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Animal Model;Binding Proteins;Bleomycin;blood pressure elevation;Blood Vessels;BMPR2 gene;Bone Morphogenetic Proteins;Bronchoalveolar Lavage Fluid;cell growth;cell motility;Cells;Cessation of life;Chronic;Clinical;Complex;Complication;cost;Data;Dependovirus;design;Development;Diagnosis;Disease;Endothelial Cells;Endothelium;Exhibits;extracellular;Fibroblasts;Functional disorder;Goals;Heart;hemodynamics;Histologic;Human;Hypoxia;hypoxia-induced pulmonary hypertension;idiopathic pulmonary fibrosis;indexing;Inhalation;innovation;Interstitial Lung Diseases;Knock-out;Knockout Mice;LDL-Receptor Related Protein 1;Lung;Lung Diseases;Measurement;Medial;Mediating;Medical;Membrane;Molecular;mortality;mouse model;Mus;Muscle;overexpression;paracrine;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;Pilot Projects;Play;Process;prognostic indicator;protein activation;Proteins;pulmonary arterial hypertension;pulmonary arterial pressure;Pulmonary artery structure;Pulmonary Fibrosis;Pulmonary Hypertension;Pulmonary Pathology;pulmonary vascular remodeling;Pulmonary Vascular Resistance;receptor;Regulation;Resistance;response;right ventricular failure;Right Ventricular Hypertrophy;Role;Sampling;Secondary to;Severities;side effect;Signaling Protein;Smooth Muscle Myocytes;spatiotemporal;Stimulator of Interferon Genes;Stimulus;Structure of parenchyma of lung;Systolic Pressure;Testing;therapeutic target;Tissues;Transcriptional Regulation;Treprostinil;Up-Regulation;Vascular Diseases;Vascular Endothelial Cell;Vascular remodeling;Ventricular

PROJECT_TITLE: The pathophysiology of vascular remodeling in pulmonary hypertension

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-M (03)]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PHR: Alzheimer’s dementia (AD) and age-related cognitive decline have a large impact on the health of Americans. Age is the primary risk factor for AD and cognitive decline. Aging can be chronologic aging (time since birth) or biological aging that may differ substantially from chronological age for some individuals. Exercise is a promising intervention to mitigate cognitive decline in older adults. Understanding the impact of exercise on biological aging and cognitive function could assist in improving interventions to impede the development of AD and age-related cognitive decline.

PI_NAMEs: CONLEY, YVETTE P (contact);ERICKSON, KIRK I

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: accelerated epigenetic aging;Aerobic Exercise;Age;Age-associated memory impairment;Aging;Algorithms;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer’s disease biomarker;American;Amyloid;Amyloid beta-42;Amyloid beta-Protein;Area;Biological;Biological Aging;biological heterogeneity;Biological Markers;Birth;Blood;blood-based biomarker;Brain;brain health;cardiorespiratory fitness;Chronology;Cognitive aging;cognitive function;cognitive performance;Communities;Data;Deceleration;Dementia;deprivation;Detection;Development;DNA Methylation;Dose;early life adversity;Epigenetic age;epigenetic aging;epigenetic clock;Epigenetic Process;executive function;Exercise;exercise intensity;exercise intervention;Health;Heterogeneity;Hippocampus;human old age (65+);Impaired cognition;Impairment;improved;indexing;Individual;Intervention;Intervention Trial;Life Style;light intensity;Link;Measures;Mediating;Memory;mild cognitive impairment;Neighborhoods;Neurocognition;Neurocognitive;Neurodegenerative Disorders;neuroimaging;novel therapeutic intervention;older adult;Participant;Performance;Plasma;Positron-Emission Tomography;precision medicine;processing speed;Randomized;Research;response;Role;social deprivation;social health determinants;Social Network;Socioeconomic Status;Stress;Stretching;tau-1;Time;United States;Variant;VO2max;White Matter Hyperintensity;whole genome;β-amyloid burden

PROJECT_TITLE: Epigenetic Aging Cognitive Function and Exercise in Older Adults

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Liver Disease;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE We propose to evaluate an innovative, newly developed measurement for bioavailable copper in the circulation known as “accurately determined non-ceruloplasmin bound copper (ANCC)”, as a biomarker for treatment and outcome of Wilson Disease, an inherited disorder of copper metabolism where excess copper causes progressive injury to the liver, brain, and other organs. These studies will benefit treatment monitoring of current and investigational therapies for Wilson disease and have a wider impact on human health by enhancing our ability to assess copper status in health and in disease, which is important for conditions associated with low copper levels due to altered intestinal absorption or tissue distribution, and for new blood vessel formation and cancer therapy.

PI_NAMEs: SCHILSKY, MICHAEL L (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Acute Liver Failure;advocacy organizations;Aftercare;Agreement;Biliary;Binding;Biochemical;Biological Assay;Biological Availability;Biological Markers;Biological Specimen Banks;Blood specimen;Blood Tests;blood vessel development;Brain;burden of illness;cancer therapy;Cell Survival;Cellular Metabolic Process;Cessation of life;Circulation;Clinical;Clinical Research;cohort;Collaborations;Copper;cost;cost effective;cost-effectiveness evaluation;Data;Diagnosis;disability;Disease;disease phenotype;disease registry;Dose;Drug or chemical Tissue Distribution;Enrollment;Event;Excretory function;Extrahepatic;Future;Health;Hepatic;Hepatolenticular Degeneration;Hereditary Disease;Hospitals;Human;indexing;innovation;International;Interruption;Intestinal Absorption;Investigational Therapies;Laboratories;laboratory experiment;Liver;Liver diseases;liver injury;liver transplantation;Maintenance;Maintenance Therapy;Measurement;Measures;Medical;Metabolism;Metals;Methods;Modeling;Monitor;multidisciplinary;Natural History;Neurologic;Organ;Outcome;outcome prediction;Pathologic;Patient advocacy;Patient Care;patient/disease registry;Patients;Penicillamine;Pharmacological Treatment;Phase;Phenotype;Play;potential biomarker;Process;prognostic index;prognostic indicator;prognostication;Quality of life;Role;Salts;Sampling;secondary analysis;Site;Specialist;Standardization;Testing;Therapy Clinical Trials;Time;timeline;Tissues;treatment and outcome;Treatment Failure;treatment optimization;Treatment outcome;treatment trial;Triethylenetetramine;Universities;urinary;Urine;Validation;Zinc

PROJECT_TITLE: Biomarkers for treatment monitoring and prognostication of disorders of hepatic copper metabolism

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: The inferior olivary nucleus plays a vital role in cerebellar function and motor control, and olivary degeneration is central to the pathophysiology of tremor and ataxia. We will examine a shared mechanism for degeneration in the olive that results from intrinsic molecular pathology as well as from extrinsic denervation of cerebellar input. This proposal has profound implications for development of treatment directed towards improving inferior olivary neuron survival and function.

PI_NAMEs: SHAKKOTTAI, VIKRAM GOVINDARAJU (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Address;Ataxia;Behavior;Brain Stem;calbindin;Cell Death;Cell Survival;Cells;Cellular Morphology;Characteristics;Data;Dendrites;Denervation;Dissociation;Electrophysiology (science);Etiology;Event;excitotoxicity;Exhibits;Functional disorder;Hypertrophy;improved;in vivo;Inferior;inhibitory neuron;insight;Ion Channel;Knock-in;Knock-in Mouse;Length;loss of function;Maps;Medulla oblongata olive;Membrane;Modeling;Molecular;molecular pathology;Morphology;motor behavior;motor control;mouse model;Mus;mutant;Nerve Degeneration;neuronal excitability;neuronal survival;Neurons;novel;Olives - dietary;patch clamp;Pathology;Physiology;Play;Potassium Channel;Predisposition;prevent;Purkinje Cells;Role;Slice;Source;Spinocerebellar Ataxias;Synapses;Technology;Testing;Therapeutic;therapy development;Transcript;Transgenic Mice;Tremor;Type 1 Spinocerebellar Ataxia

PROJECT_TITLE: Understanding Degeneration in Neurons of the Inferior Olivary Nucleus

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Atrial fibrillation is responsible for frequent hospitalizations, a decreased quality of life, and increased risks of stroke and death. Recent evidence shows that abstinence from alcohol reduces the burden of atrial fibrillation, and our recent work suggests that alcohol may immediately heighten the risk of a near-term atrial fibrillation event. This research seeks to develop and study a novel tool using commonly used smartphones and smart watches to promote abstinence specifically among individuals with atrial fibrillation and to provide the first definitive evidence that consuming alcohol causes a discrete atrial fibrillation episode.

PI_NAMEs: MARCUS, GREGORY M (contact)

PROGRAM_OFFICER_NAME: LIN, LI

PROJECT_TERMS: Abstinence;Acute;alcohol abstinence;Alcohol consumption;Alcohols;Arrhythmia;Atrial Fibrillation;Behavioral;Cellular Phone;Cessation of life;Clinical;Collaborations;Consumption;Coupled;Data;digital;digital health;digital intervention;digital tool;drinking;Electrocardiogram;Electrophysiology (science);Event;fitbit;Guidelines;Heart Atrium;Hospitalization;human centered design;implementation research;Individual;Instruction;Intravenous;Measures;Methods;mobile application;novel;Outcome;Participant;Patient Self-Report;Patients;Pharmaceutical Preparations;Physiology;Placebos;Quality of life;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;Research;Risk;sensor;smart watch;stroke risk;Technology;Text;Time;tool;United States National Institutes of Health;Visualization;Work

PROJECT_TITLE: Digital Interventions to Study and Influence the Alcohol-Atrial Fibrillation Connection

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Prevention;Social Determinants of Health;Telehealth

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative Hypertension (high blood pressure) affects 1 in 3 of the over 90 million people currently enrolled in Medicaid, and lower anti-hypertensive (AH) medication adherence rates are found among Medicaid enrollees compared to other insured populations, which poses a major barrier to controlled blood pressure. Using short-term incentives to support action planning is an evidence- and theory-based approach to forming healthy pill-taking habits and establishing long-term AH medication adherence. This study proposes to adapt the widely-used Wellth smartphone app to remotely deliver the combination of incentives and action planning that if found effective is readily scalable for improving the self-management of hypertension and other chronic conditions.

PI_NAMEs: STECHER, CHAD DANIEL (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Adherence;adherence rate;Adult;Affect;American;Anti-Hypertensive Agents;Arizona;arm;Behavior;behavior change;behavioral economics;Blood Pressure;blood pressure medication;blood pressure reduction;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Cessation of life;Chronic;Coffee;Cognitive;combat;Complex;Control Groups;cost;Cues;Data;Drops;economic disparity;efficacy trial;Emergency Situation;Enrollment;ethnic minority;Evaluation;Future;group intervention;Habits;Health;health care service utilization;health disparity;Health Expenditures;Heart failure;Home;Household;Human Resources;Hypertension;hypertension control;hypertension treatment;hypertensive;implementation barriers;implementation research;improved;Incentives;Income;Inpatients;Intervention;intervention effect;intervention refinement;Interview;Maintenance;Measures;Medicaid;Medicaid services;medication compliance;Methods;mHealth;Morbidity - disease rate;mortality;Myocardial Infarction;novel;Outcome;Participant;Patients;Persons;Pharmaceutical Preparations;Photography;pill;Population;post intervention;primary outcome;Process;racial minority;Randomized;remote delivery;Research;response;Rewards;risk mitigation;scale up;secondary outcome;Self Management;Service provision;smartphone application;Stroke;Testing;theories;therapy adherence;Time;treatment adherence;Treatment Efficacy;Visit;Vulnerable Populations

PROJECT_TITLE: mobile Cued Adherence Therapy (mCAT): a scalable habit formation intervention to improve blood pressure medication adherence based on a widely used smartphone app

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Asthma;Genetics;Lung

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE The role of the two FOXP3 isoforms (FOXP3 FL and FOXP3 ΔE2) in health and disease has not clearly defined. In this application, we propose to use unique mouse strains developed in our lab (strains expressing only one isoform, and the other co-expressing both isoforms through alternative splicing as in humans) to define the molecular and cellular mechanisms for the FOXP3 isoforms regulating immunopathology of allergic airway inflammation.

PI_NAMEs: KAPLAN, MARK H;ZHOU, BAOHUA  (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Adrenal Cortex Hormones;Affect;airway inflammation;Allergens;Allergic;allergic airway inflammation;Allergic Disease;Allergic inflammation;Alternative Splicing;Amino Acid Sequence;Antigens;Asthma;asthmatic;Autoantibodies;Autoimmune Diseases;Bronchoalveolar Lavage;CD4 Positive T Lymphocytes;Cells;Chronic;Clinical Protocols;Clinical Research;cytokine;Data;Development;differentiation in vitro;Disease;Elements;Exons;Exposure to;FOXP3 gene;genomic locus;Health;Helper-Inducer T-Lymphocyte;histone modification;Homeostasis;Human;human disease;humanized mouse;Hypersensitivity;IgE;IL17 gene;IL9 gene;Immune;Immunology;immunopathology;immunoregulation;Immunotherapy;In Vitro;in vivo;Inflammation;Inhalation;insight;Interleukin-13;Interleukin-4;Interleukin-5;Interleukin-9;Knock-in;Lead;Learning;Length;Mediating;Modeling;Modification;Molecular;mouse model;Mouse Strains;Mus;Mutation;novel;Oligonucleotides;patient subsets;Patients;Peripheral;Peripheral Blood Mononuclear Cell;Phenotype;Physiological;Play;Prevention;Production;Protein Isoforms;Publications;Regulation;Regulatory Element;Regulatory T-Lymphocyte;Respiratory Mucosa;Risk;Risk Factors;RNA Splicing;Role;Science;Severities;Severity of illness;Study models;Symptoms;systemic autoimmune disease;Systemic Lupus Erythematosus;T cell therapy;T-Cell Development;Testing;transcription factor;transdifferentiation;Wild Type Mouse

PROJECT_TITLE: FOXP3 ΔE2 isoform in asthma severity and persistence

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Assistive Technology;Atherosclerosis;Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: PROJECT NARRATIVE  Polymeric bioresorbable vascular scaffolds (BVSs) have emerged as a potential solution to problems with traditional metal stents by providing initial support to prevent recoil and slowly degrading to restore vasomotion and eliminate residual foreign materials that may contribute to restenosis. However, currently approved BVS have higher incidences of major cardiovascular events and clotting in small arteries due to their strut size and slow, pro-inflammatory degrading polymer. We will develop and test in vivo 3D-printed, low profile, drug-eluting, biocompatible and mechanically functional BVS.

PI_NAMEs: AMEER, GUILLERMO ANTONIO (contact);SUN, CHENG

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: 3D Print;Absorbable Implants;absorption;Advanced Development;Antioxidants;Arteries;Atherosclerosis;Biocompatible Materials;biocompatible scaffold;biodegradable polymer;biomaterial compatibility;Blood flow;Blood Vessels;Cardiac;Cardiology;Cardiovascular system;Catheters;Citrates;Clinical;Clinical Research;Coagulation Process;Collaborations;Contrast Media;Coronary Arteriosclerosis;Coronary artery;cost;Data;design;Devices;Diabetes Mellitus;Diameter;Dimensions;Domestic Pig;Drug Delivery Systems;drug standard;Endothelium;Ensure;Epidemic;Event;fabrication;Family suidae;FDA approved;Fluoroscopy;Goals;Health Care Costs;Histopathology;Human;human disease;improved outcome;In Vitro;in vivo;in vivo evaluation;Incidence;Inflammation;Inflammatory;iodixanol;Legal patent;Liquid substance;manufacture;Manufacturer;manufacturing technology;Marketing;Measurement;mechanical properties;Mechanics;Medical Device;Metabolic syndrome;Metals;Methodology;Modeling;Molybdenum;Morbidity - disease rate;mortality;Musculoskeletal;Operative Surgical Procedures;Outcome;Performance;Peripheral arterial disease;Persons;Pharmaceutical Preparations;Polymers;porcine model;prevent;Procedures;Production;Property;Protocols documentation;Research;Research Contracts;Research Proposals;Residual state;restenosis;revascularization;Risk;Safety;scaffold;scale up;SDZ RAD;Second Look Surgery;Stents;Structure;Techniques;Technology;Thick;thrombogenesis;Thrombosis;thrombotic;Tissues;translational impact;Treatment outcome;ultrasound;vasomotion;Visualization;Withdrawal;Work

PROJECT_TITLE: Low-Profile 3D-Printed Radiopaque Bioresorbable Vascular Scaffolds

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-X (83)]


ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: PROJECT NARRATIVE Mitochondrial dysfunction is implicated in a wide range of rare and common human diseases, yet the underlying features of this dysfunction are often poorly defined and extremely difficult to rectify. This proposal aims to elucidate the role of reversible phosphorylation in regulating select mitochondrial functions and to connect this phosphorylation to specific mitochondrial phosphatases. Completion of these goals will advance our basic understanding of mitochondrial metabolic regulation and define specific phosphatases as potential therapeutic targets for the treatment of mitochondrial dysfunction.

PI_NAMEs: PAGLIARINI, DAVID J (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Acute;acyl-CoA dehydrogenase;Affect;Albumins;Animals;Architecture;ATP phosphohydrolase;Award;Biochemistry;Biological Assay;Branched-Chain Amino Acids;Calibration;Catabolism;Cells;Cellular Assay;Chronic;Complex;CRISPR interference;Crista ampullaris;Data;Data Set;Defect;Disease;empowerment;Event;Fasting;fatty acid metabolism;fatty acid oxidation;Fatty Acids;forging;Foundations;Functional disorder;Gel;Goals;Heart failure;Human;human disease;In Vitro;Investigation;Keto Acids;knock-down;Knock-out;Laboratories;Link;lipidomics;Liver;LoxP-flanked allele;Malignant Neoplasms;Mass Spectrum Analysis;Medicine;member;Metabolic;Metabolic Diseases;Metabolic Pathway;metabolic phenotype;Metabolic stress;Metabolic syndrome;Metabolism;mimetics;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Mitochondrial Proteins;Modification;Molecular Profiling;Monitor;Motor Activity;Mus;mutant;Neonatal Mortality;Neurodegenerative Disorders;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutic intervention;Obesity;Organelles;Orphan;oxidation;Oxidoreductase;Pathogenicity;Pathway interactions;Phosphoproteins;phosphoproteomics;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphorylation Site;Phosphotransferases;Physiological;Physiology;Post-Translational Protein Processing;Preparation;Process;Protein Dephosphorylation;protein function;Protein Import;Protein phosphatase;Proteins;pyruvate dehydrogenase;Radiolabeled;Regulation;Reproducibility;Resources;Respiration;respiratory;response;Role;Site;stoichiometry;System;Testing;therapeutic target;unpublished works;Work;Yeasts

PROJECT_TITLE: Regulation of Mitochondrial Function by Orphan Protein Phosphatases

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: EL PASO

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS EL PASO

PHR: PROJECT NARRATIVE A hallmark of substance use disorders is the continued pursuit of drug despite high costs. To understand this pattern of behavior, we will develop and validate a computational and neurological model of costly drug consumption. Determining the mechanisms underlying drug pursuit is timely and highly significant given the ongoing substance use crisis in the United States.

PI_NAMEs: FRIEDMAN, ALEXANDER  (contact);MOSCHAK, TRAVIS M;ODELL, LAURA ELENA

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Aging;Animals;Automobile Driving;Behavior;Brain;Cocaine;Computer Models;Consumption;Corpus striatum structure;cost;Cost-Benefit Analysis;Costs and Benefits;craving;Decision Making;Development;Drug Costs;Drug Modelings;drug seeking behavior;Drug usage;Electrophysiology (science);Emerging Technologies;Evaluation;Focused Ultrasound;Future;Goals;Human;in vivo;Individual;Intervention;Jail;Knowledge;Magnetic Resonance Imaging;Measures;Mediating;Methods;Modeling;network models;neural;neural circuit;Neurobiology;Neurological Models;Neurons;neuroregulation;novel;Opioid;optogenetics;Oxycodone;pars compacta;Pathway interactions;Pattern;Pharmaceutical Preparations;Phenotype;Play;predictive modeling;Punishment;Rattus;Recording of previous events;recruit;relapse prevention;relapse risk;resilience;Rewards;Role;Self Administration;sex;Site;Stress;striosome;substance use;Substance Use Disorder;Substantia nigra structure;System;Techniques;Testing;Time;United States;Water;Withdrawal;Work

PROJECT_TITLE: A2: Striosomal models of drug use and cost

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Pulmonary Hypertension;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Project Narrative One of the common complications of pulmonary hypertension is right-sided heart failure associated with poor prognosis in patients. We have developed preliminary data showing that right-sided heart failure, in part, is mediated by excessive activation of cardiac fibroblasts induced by the specific enzyme named c-Src. This research will allow us to design a novel strategy for the management of right-sided heart failure during pulmonary hypertension.

PI_NAMEs: JHUN, BONG SOOK ;O-UCHI, JIN  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Adjuvant Therapy;Adult;ATP Synthesis Pathway;Attenuated;Basal Cell;Binding;Bioenergetics;C-terminal;Cardiac;Cardiac Myocytes;Cell Physiology;Chronic;Clinical;conventional therapy;coronary fibrosis;Data;design;Development;Dimerization;Dominant-Negative Mutation;Endoplasmic Reticulum;Enzymes;Failure;Fibroblasts;Fibrosis;Generations;Genetic;Goals;Heart;Hypoxia;in vivo;Injury;inorganic phosphate;Inositol;insight;ITPR1 gene;Lipids;Maintenance;Mediating;Mitochondria;Modeling;Molecular;Muscle Cells;Names;novel;novel strategies;novel therapeutic intervention;Outcome;Outer Mitochondrial Membrane;oxidation;Oxidation-Reduction;Pathologic;Pathology;Patients;Phosphorylation;Play;pre-clinical;Prognosis;promoter;protein-tyrosine kinase c-src;pulmonary arterial hypertension;Pulmonary Hypertension;Rattus;Reactive Oxygen Species;receptor;Regulation;Reporting;Research;response;right ventricular failure;Right Ventricular Hypertrophy;Role;Sarcoplasmic Reticulum;Signal Transduction;Signaling Molecule;Site;SRC gene;Stress;Structure;System;Tail;Testing;Therapeutic;Tissue Sample;Tissues;Tyrosine Phosphorylation;uptake;Ventricular

PROJECT_TITLE: Role of ER-mitochondria contact sites in Right Ventricular Fibrosis

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Burden of Illness;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: PROJECT NARRATIVE By 2065 the U.S. foreign-born population is expected to reach 78 million persons. This project will overcome many of the previous challenges in studying death rates among the foreign born by leveraging unique linked data from the U.S. Census Bureau and the Social Security Administration. The study will examine how social and economic factors over the life course, including earnings trajectories, are associated with death risks.

PI_NAMEs: MEHTA, NEIL  (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Achievement;Address;Age;American;Birth;Censuses;Cessation of life;Characteristics;cohort;Country;Data;data integration;Data Linkages;Data Security;Data Sources;Databases;Death Rate;Death Records;Demography;design;Economic Factors;Economics;Education;Ethnic Origin;experience;Gender;geographic disparity;Geography;Growth;Health;Heterogeneity;Household;human old age (65+);Immigrant;Individual;innovation;interest;Internal Migrations;Knowledge;Language;Life Cycle Stages;Life Expectancy;Link;Measures;Mediating;men;Migrant;migration;mortality;mortality disparity;mortality risk;novel;Pattern;Persons;Policies;Population;Population Heterogeneity;Portraits;Race;Recording of previous events;Records;Refugees;Research;residence;Residential Mobility;Role;Sample Size;Sampling;Shapes;social;social factors;Social Security;Societies;sociodemographic factors;socioeconomics;Structure;Subgroup;Testing;United States;United States Social Security Administration;Urbanicity;Variant;Vietnamese;Vital Statistics;Woman

PROJECT_TITLE: Demography of Immigrant Mortality in the United States: Leveraging Novel Census Linkages to Death Records, Earnings Trajectories, and Residential Mobility

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-9 (M1)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Prevention;Recovery Support Services;Substance Misuse;Telehealth;Underage Drinking

ORG_CITY: STANFORD

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE This project aims to test the efficacy of an innovative text-based intervention, ASPIRE, designed not just to address cognitive and behavioral elements but also to modify crucial environmental factors such as peers that influence drinking behaviors. Preliminary results from a pilot trial are promising, and our upcoming research aims to further test ASPIRE's effectiveness, understand the mechanisms driving behavior change, and identify which subgroups stand to benefit most, aligning with NIH's emphasis on non-colligate young adults.

PI_NAMEs: SUFFOLETTO, BRIAN P (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: Accountability;Address;aged;Alcohol consumption;alcohol involvement;alcohol related consequences;Alcohols;asynchronous communication;Attitude;Automobile Driving;Behavior;behavior change;Behavior Therapy;Behavioral;binge drinking;blind;Cognitive;Cognitive Therapy;cohort;college;comparative efficacy;Comparative Study;Data;design;drinking;drinking behavior;driving behavior;Effectiveness;effectiveness evaluation;efficacy testing;efficacy trial;efficacy validation;Elements;Environmental Risk Factor;Evaluation;evidence base;expectation;Exposure to;Feedback;Female;Future;Geography;Goals;hazardous drinking;help-seeking behavior;improved;Individual;Influentials;Informal Social Control;injury-related death;innovation;interest;Intervention;Location;Measures;Mediating;Mediator;men;Meta-Analysis;Methods;National Institute on Alcohol Abuse and Alcoholism;novel;Outcome;outreach;Participant;Patients;Pattern;peer;peer influence;peer support;Physical environment;pilot trial;Play;Population;Public Health;Qualifying;Randomized;randomized trial;recruit;Reporting;Research;Resistance;Role;Sampling;Self Efficacy;Severities;skills;social cognitive theory;social media;social norm;societal costs;Standardization;Strategic Planning;Subgroup;success;Surveys;Testing;Text;Text Messaging;text messaging intervention;therapy design;Thinking;Time;tool;United States National Institutes of Health;university student;US State;Woman;young adult;young adult alcohol use

PROJECT_TITLE: ASPIRE to Change: Leveraging Text Messaging Peer Support Coaching to Mitigate Hazardous Alcohol Consumption in Non-Collegiate Young Adults

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Clinical Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Disability Research;Lung;Mental Health;Neurosciences;Pediatric

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative The proposed research is relevant to public health by providing new data on rates and timing of hypoxia, impact of early exposure to anesthesia, and the earliest markers of brain growth/function among infants with and without oral cleft. This knowledge will be essential in guiding treatment decisions related to sleep studies, use of pre-surgical orthopedics, and timing of surgery that will ultimately improve outcomes for infants with oral cleft. The goals of this project advance the NIH mission to use obtained knowledge about living systems to enhance health and reduce disability.

PI_NAMEs: CONRAD, AMY LYNN (contact)

PROGRAM_OFFICER_NAME: GRISIUS, MARGARET

PROJECT_TERMS: Academic achievement;Acoustics;Adolescent;Adolescent and Young Adult;Age Months;airway obstruction;Anesthesia procedures;Anesthetics;Animals;Audiology;Biological Factors;Brain;brain cell;Brain imaging;Brain region;brain volume;Cell Death;cell motility;Cells;Central Nervous System;cerebral oxygenation;Characteristics;Child;Cleft lip with or without cleft palate;Clinical;Cognitive deficits;college;comorbidity;Cortical Dysplasia;Data;Development;disability;early life exposure;Enrollment;Etiology;Evaluation;Event;Exposure to;frontal lobe;Functional disorder;functional near infrared spectroscopy;Genetic;Goals;Growth;Health;Hypoxia;Image;imaging modality;improved outcome;Incidence;Infant;infant outcome;Inferior;innovation;Intervention;Knowledge;Label;Language;Language Development;Language Disorders;language outcome;language processing;Lead;Learning;Learning Disabilities;Left;Life;Lip structure;Magnetic Resonance Imaging;male;Measures;Medical;migration;Mission;MRI Scans;multimodality;National Institute of Dental and Craniofacial Research;neural;neural growth;neural patterning;neurodevelopment;neuroimaging;Neurological observations;Neurons;Neurophysiology - biologic function;Neuropsychology;novel;Operative Surgical Procedures;oral cleft;Organism;Orthopedics;Outcome;Palate;Participant;Patient-Focused Outcomes;Pattern;Performance;Production;Protocols documentation;Public Health;Pulse Oximetry;Reading;Reading Disorder;Research;Risk;Role;Sample Size;sex;Sex Differences;Sleep;Speech;Speech Development;Structure;Subgroup;Syndrome;Techniques;theories;Time;Treatment Protocols;United States National Institutes of Health;white matter;Work

PROJECT_TITLE: Speech Development and Brain Structure/Function in Infants with Isolated Oral Clefts: Relationship Anesthesia Exposure and Oxygenation

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because elucidation of the cellular, molecular, and electrophysiological changes underlying epilepsy after head trauma (posttraumatic epilepsy, PTE) will increase understanding of the pathogenesis of PTE. The project is relevant to NIH’s mission, as the research pursues fundamental knowledge of disease mechanisms in the brain, which may provide a foundation for the development of novel and more effective strategies to treat the major clinical problem of PTE.

PI_NAMEs: BINDER, DEVIN K (contact);PEDAPATI, ERNEST VIJAY;SANTHAKUMAR, VIJAYALAKSHMI

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Acute;Anatomy;Animal Model;Astrocytes;Biological Markers;Brain;Cell Death;Cell Physiology;cell type;Cells;cellular targeting;Chronic;Clinical;controlled cortical impact;Craniocerebral Trauma;Data;Development;Disease;Distant;Electrodes;Electroencephalography;Electrophysiology (science);Epilepsy;Epileptogenesis;excitotoxicity;Exhibits;experimental study;Foundations;Functional disorder;Glutamates;Goals;Hippocampus;Impairment;injured;Injury;Knowledge;Military Personnel;Mission;Modeling;Molecular;molecular targeted therapies;Monitor;multi-electrode arrays;multimodality;Mus;nerve injury;Neuroglia;Neurons;novel;Pathogenesis;Pathology;Permeability;Physiological;Population;Post-Traumatic Epilepsy;predictive marker;Predisposition;Process;Public Health;Pyramidal Cells;Reproducibility;Research;Seizures;Site;Slice;Surface;Synapses;targeted treatment;Techniques;Testing;Time;Tissues;Trauma;Traumatic Brain Injury;United States National Institutes of Health;Western Blotting

PROJECT_TITLE: Acute neural injury and posttraumatic epilepsy

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Chronic Pain;Clinical Research;Comparative Effectiveness Research;Health Services;Osteoarthritis;Pain Research;Patient Safety;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE / RELEVANCE Revision anterior cruciate ligament (ACL) reconstruction results in inferior outcomes compared with primary reconstructions, thus limiting individuals from returning to their previous activities. This multicenter, multi-surgeon prospective study will allow determination of the long-term clinical predictors of outcomes following revision ACL reconstruction. Identifying risk predictors will guide revision surgical decisions and post-surgical activity and lifestyle guidance, as strategies to predict, modify and decrease this risk will change patient’s lives.

PI_NAMEs: WRIGHT, RICK W (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Age;aging population;American;Anterior Cruciate Ligament;anterior cruciate ligament injury;anterior cruciate ligament reconstruction;articular cartilage;Back;Caring;Clinical;clinical practice;cohort;Cohort Analysis;Cohort Studies;comparative effectiveness;Degenerative polyarthritis;demographics;Deterioration;Disease Progression;DNA Repository;Enrollment;Etiology;follow-up;genetic predictors;genetic variant;Genetic Variation;Genomics;Glean;Grant;Incidence;indexing;Individual;Inferior;Injury;instrument;Kellgren-Lawrence grade;Knee Osteoarthritis;knee replacement arthroplasty;Lateral;Life Style;Longitudinal cohort;Longterm Follow-up;Lower Extremity;Measurement;Measures;Medial;Meniscus structure of joint;Occupations;Operative Surgical Procedures;Orthopedics;Outcome;Outcome Assessment;Outcome Measure;Pain;Pathology;Patient Outcomes Assessments;Patient risk;Patient-Focused Outcomes;Patients;Physical Examination;Physicians;predict clinical outcome;Private Practice;profiles in patients;prospective;Prospective Studies;radiological imaging;reconstruction;Repeat Surgery;Reporting;repository;Risk;Risk Factors;Risk Marker;Second Look Surgery;sex;Shapes;Site;Smoking Status;Societies;Sports Medicine;Structure;Surgeon;Surgical Pathology;surgical risk;Symptoms;Time;Traumatic Arthropathy;Treatment Effectiveness;United States;Western Ontario and McMaster Universities Arthritis Index

PROJECT_TITLE: Revision ACL Reconstruction: A Comparative Effectiveness Treatment Study

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Natural Products;Neurosciences;Rare Diseases

ORG_CITY: IRVINE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Public Health Relevance Botulinum neurotoxins (BoNTs) are extremely potent bacterial toxins causing the paralytic botulism syndrome. We propose to develop a platform for intra-neuronal delivery of nanobodies in order to neutralize the toxin inside the intoxicated neurons and accelerate recovery of botulism. The accomplishment of our goals will result in novel antidotes to treat post-exposure botulism, as well as a versatile platform for delivery of protein therapeutics to act on other intra-neuronal targets.

PI_NAMEs: JIN, RONGSHENG  (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: Acceleration;Acetylcholine;Affect;Affinity;Alpaca;Animals;anti-toxin;Antibodies;Antidotes;Architecture;Asphyxia;Bacterial Toxins;Binding;Biochemical;Botulinum Toxins;Botulism;Cell Surface Receptors;cell type;Cells;Cessation of life;Chimeric Proteins;Clinical;Custom;Cytosol;delivery vehicle;design;Diphtheria Toxin;Disease;effective therapy;efficacy study;efficacy testing;Engineering;Epitopes;Equus caballus;flexibility;Future;Genes;Genetic;Glycoproteins;Goals;Human;Immunize;immunogenicity;Intensive Care;Intoxication;Light;Modeling;Motor Neurons;Mus;Muscle;nanobodies;neuromuscular;Neuromuscular Junction;Neurons;neurotoxic;novel;Paralysed;Patients;Peptide Hydrolases;Performance;Prevalence;prevent;Prophylactic treatment;protective efficacy;Protein Engineering;Proteins;public health relevance;receptor;receptor binding;Recombinants;Recovery;screening;Serotyping;Serum;SNAP receptor;Specificity;Surface;symptom treatment;Symptoms;Synaptic Receptors;Synaptic Vesicles;Syndrome;targeted delivery;Testing;Therapeutic;therapeutic protein;Toxic effect;Toxin;Transportation;uptake;Work

PROJECT_TITLE: Developing novel botulism antidotes and a platform for intra-neuronal delivery of nanobodies

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Genetics;Intellectual and Developmental Disabilities (IDD);Pediatric;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: PROJECT NARRATIVE We study rare, human Congenital Disorders of Glycosylation (CDG) and basic cell biology of glycosylation. Each informs the other and we'll continue this approach.

PI_NAMEs: FREEZE, HUDSON H. (contact)

PROGRAM_OFFICER_NAME: ZAGHLOUL, NORANN

PROJECT_TERMS: Acids;Affect;Aleuria aurantia lectin;Alleles;alpha 1-Antitrypsin;Antibodies;Ataxia;Atrophic;Basic Science;Behavioral;Binding;Biochemical;Biological Assay;brain abnormalities;CAMLG gene;Candidate Disease Gene;candidate identification;Cell Line;Cells;Cellular biology;Clinical;Clinical Medicine;Complement;Complex;Congenital disorders of glycosylation;CRISPR library;CRISPR screen;Cytoplasm;Data;design;Developmental Disabilities;Dolichol;Enzymes;Epilepsy;Face;Fees;Fluorescence Microscopy;Fucose;Fucosidase;Fucosyltransferase;galactoside 3-fucosyltransferase;Genes;Genetic;genetic pedigree;Genetic Transcription;Glucose;Glycobiology;Glycoproteins;glycosylation;Goals;Golgi Apparatus;Golgi Targeting;Guanosine Diphosphate Fucose;Guanosine Diphosphate Mannose;Human;In Situ;inhibitor;insight;Intellectual functioning disability;knock-down;Label;Lectin;Ligation;Link;Location;macromolecule;man;Mannose;Mass Fragmentography;Measures;Membrane;Metabolic;Microcephaly;misfolded protein;Modeling;Modification;Monosaccharides;Morphology;mutant;Mutate;Nature;Pathogenicity;Pathway interactions;Patients;Phenotype;Phosphorylation;Polysaccharides;Post-Translational Protein Processing;preference;Protein Analysis;protein transport;Proteins;Proteomics;Reaction;Recycling;Regulation;segregation;Seizures;Serum;Signaling Molecule;Site;Small Interfering RNA;Source;spasticity;Stream;sugar;syntaxin 5;Testing;Therapeutic;trafficking;Transferase;Validation;Variant;variant of unknown significance;whole genome;α-Dystroglycan

PROJECT_TITLE: New Congenital Disorders of Glycosylation: Therapy and Models

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative  APOE ε2 and ε4 genotypes are associated with risk of Alzheimer’s disease (AD) and peripheral lipid traits and inflammatory markers. The strength of these associations varies with ancestry, and we have previously shown that ancestry-specific APOE haplotypes influence AD risk beyond the effects of ancestry genome-wide. Our proposed analyses of variation among admixed participants will allow us to recognize the genetic modifiers of AD risk that vary between ancestry-specific APOE haplotypes, and whether these variants have pleiotropic effects on peripheral lipid traits or inflammatory markers.

PI_NAMEs: BLUE, ELIZABETH ELOYCE (contact)

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TERMS: Address;African;African American;African American population;African Caribbean;Alleles;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Bioinformatics;bioinformatics pipeline;Biological Markers;Biological Models;Black Populations;C-reactive protein;Caribbean Hispanic;cell type;Data;Data Set;Dementia;Endosomes;European;Frequencies;Future;Gene Expression;Gene Expression Regulation;gene function;Genes;Genetic;Genetic Variation;Genome;genome-wide;Genomics;Genotype;Goals;Haplotypes;Heritability;High Prevalence;Hispanic Populations;Human;In Vitro;in vivo;Individual;Inflammation;Inflammatory;inflammatory marker;insight;Joints;Link;lipid biosynthesis;Lipids;Measures;Morbidity - disease rate;mortality;Participant;Pathologic;Pathway interactions;Peripheral;Phenotype;phenotypic data;pleiotropism;Population;Population Genetics;Probability;protective effect;Puerto Rican;Regulatory Element;Research;Risk;risk variant;Sampling;Testing;therapeutic target;trafficking;trait;Trans-Omics for Precision Medicine;Variant;whole genome;Work

PROJECT_TITLE: Interrogating the protective effect of African APOE alleles on Alzheimer's disease risk through pleiotropy

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: H. PROJECT NARRATIVE Young adulthood is a critical period for alcohol initiation and changes in alcohol use patterns, including increased risk for alcohol misuse and alcohol use disorders (AUD), that are strongly influenced by social factors. Previous research shows that acute alcohol responses in the lab are greater when with another person compared to when drinking alone (i.e., social facilitation of alcohol effects), and the investigative team’s preliminary evidence shows sensitivity to social facilitation of alcohol effects may be a novel risk factor for future alcohol misuse. This proposal will use a multi-method laboratory/Ecological Momentary Assessment/longitudinal follow-up approach to examine the role of social facilitation of alcohol effects on prospective alcohol misuse.

PI_NAMEs: KIRKPATRICK, MATTHEW GESNER;PANG, RAINA  (contact)

PROGRAM_OFFICER_NAME: ZHA, WENXING

PROJECT_TERMS: Acute;Affect;Affective;affiliative behavior;alcohol consequences;Alcohol consumption;alcohol effect;alcohol expectancy;alcohol misuse;alcohol related consequences;alcohol related problem;alcohol response;alcohol risk;alcohol use disorder;alcohol use initiation;Alcohols;Behavior;Behavioral;Beverages;binge drinking;Code;Consumption;contagion;critical period;Development;disorder risk;drinking;Duchenne muscular dystrophy;Ecological momentary assessment;Emotional;experience;Face;Familiarity;follow-up;Friends;Future;Goals;Health;Individual;individual response;Investigation;Laboratories;Link;Literature;Malignant Neoplasms;Measures;Methods;Modeling;novel;Outcome;Participant;Pattern;Persons;Predisposing Factor;prospective;recruit;Reporting;Research;research study;response;Rewards;Risk Factors;Role;Same-sex;Scientist;Sedation procedure;Smiling;social;social attachment;Social Conditions;Social Environment;Social Facilitation;social factors;social influence;Standardization;Symptoms;Testing;Time;trait;underage drinking;Video Recording;young adult

PROJECT_TITLE: Multi-method investigation of social facilitation of alcohol effects and alcohol misuse in young adults


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative This project will return research blood biomarkers for Alzheimer Disease (AD) to healthy older adults and evaluate whether the results can be sent directly to participants in a safe and understandable way. The project will benefit current Alzheimer research and future clinical needs by developing a process for returning biomarker results that is safe and effective, which will be necessary for widespread AD diagnostic testing.

PI_NAMEs: HARTZ, SARAH ;MOZERSKY, JESSICA  (contact)

PROGRAM_OFFICER_NAME: HETTINGER, JANE CECELIA

PROJECT_TERMS: Advocate;Affect;Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease diagnostic;Alzheimer’s disease biomarker;Biological Markers;Black race;Blood;Blood Tests;blood-based biomarker;Brain;Brain Pathology;Bypass;Chronic;Clinical;clinically actionable;Cognitive;cognitive interview;cohort;Communication;Communities;Data;Dementia;design;Development;Diagnosis;Diagnostic tests;Disclosure;Education;Electronics;Enrollment;Ensure;Ethics;experience;Friends;Future;Hematological Disease;high school;human old age (65+);Individual;Interview;Knowledge;Longitudinal cohort;Mediating;medical specialties;Modality;older adult;Participant;Persons;Pharmaceutical Preparations;Pharmacotherapy;Population;Positron-Emission Tomography;pre-clinical;primary outcome;Process;Psychological Impact;psychological outcomes;psychosocial;Qualitative Evaluations;Race;Randomized;Reporting;Research;Rights;Risk;Running;Sampling;satisfaction;Series;Signal Transduction;Spinal Puncture;Structure;Surveys;Symptoms;Testing;Underrepresented Populations

PROJECT_TITLE: Returning AD biomarker Results to Community Dwelling Older Adults: Testing Modalities and Impact

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SEIR-P (80)]


ADMINISTERING_IC: NR

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

ORG_CITY: ALBUQUERQUE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF NEW MEXICO

ORG_STATE: NM

PHR: PROJECT NARRATIVE We propose the creation of the Climate and Health Allied Network for Geospatial and Environmental Science (CHANGES) Exploratory Research Center at the University of New Mexico (UNM). The overall vision of our center is to synergize expertise in geographic information science, climate science, electronic health data, epidemiology, and biomedical research to identify – and ultimately predict – gaps in health care and inform policies and actionable strategies to optimally protect our vulnerable communities in New Mexico. Our center is dedicated to leveraging transdisciplinary sciences to develop innovative strategies, solutions, and policies that empower and protect vulnerable communities, not only in New Mexico but worldwide.

PI_NAMEs: CERRATO, JOSE MANUEL (contact)

PROGRAM_OFFICER_NAME: TYUS, NADRA

PROJECT_TERMS: Address;Adopted;Affect;Air;Ally;Biomedical Research;Biometry;Cancer Biology;cancer epidemiology;Climate;climate change;climate crisis;climate science;climate-related health;Communication;Communities;community engagement;Community Health;Complex;computer science;Data;Data Science;Data Set;Dedications;Deterioration;Disasters;diverse data;Droughts;Education;electronic health data;empowerment;Engineering;Ensure;Environmental Engineering technology;Environmental Health;Environmental Impact;Environmental Science;environmental toxicology;epidemiology study;Event;experience;extreme heat;Family;Fire - disasters;Fracture;Geographic Information Systems;Geography;Health;Health Alliance;Health Benefit;health data;health disparity;Health Sciences;Healthcare;Healthcare Systems;Hispanic;hispanic community;Human;Indigenous;Information Sciences;innovation;Institution;interdisciplinary collaboration;Intervention;Life Style;Link;Malignant Neoplasms;Mexican;Mexican Americans;Modeling;Motivation;Native American community;Native Americans;Navajo;New Mexico;nutrition;Outcome;Pattern;Philosophy;Policies;Readiness;Recording of previous events;Research;Research Infrastructure;resilience;response;Rural;rural underserved;Schools;Science;Smoke;Soil;Southwestern United States;synergism;tool;Underrepresented Populations;Underserved Population;Universities;urban Native American;US State;Vision;vulnerable community;War;Water;Water Stress;Wildfire;Work

PROJECT_TITLE: UNM Climate Change and Health for the Alliance and Novelty of Geospatial and Exposure Science (CHANGES) Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LWJ-K (C2)]


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PROJECT_TERMS: Acute;Address;Advisory Committees;Ally;Award;Cancer Biology;Climate;climate change;climate impact;climate-related health;Communication;Core Facility;Data;data infrastructure;data management;data science resource;Development;Dissemination and Implementation;Ensure;Environmental Health;Environmental Science;Evaluation;Extramural Activities;Faculty;Foundations;Funding;Future;Generations;Goals;Grant;Growth;Health;Health Alliance;Health Personnel;Health Sciences;Human;improved;indigenous community;Information Dissemination;innovation;Institution;International;Leadership;member;Mentors;Modeling;Outcome;Output;Pilot Projects;Productivity;programs;recruit;Research;Research Institute;Research Personnel;Research Project Grants;Resources;Science;Strategic Planning;Strategic vision;success;Talents;Technology;Toxicology;Training;Translations;United States National Institutes of Health;vulnerable community

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Rural Health;Social Determinants of Health

PI_NAMEs: LAVIN, ROBERTA PROFFITT (contact)

PROJECT_TERMS: Address;Affect;Anxiety;Asthma;Burn injury;Cardiovascular Diseases;Caring;Cessation of life;Characteristics;Chronic;Climate;climate change;climate disaster;climate impact;climate-related health;Collaborations;Communication;Communities;community engagement;complex data;Consultations;County;dashboard;Data;data access;Data Set;Data Sources;design;Diabetes Mellitus;Disaster Planning;disaster resilience;Disasters;Disease;Disparate;Droughts;Education;Electricity;Environmental Health;Event;extreme heat;Future;Goals;hazard;Health;Health Alliance;Health Care Sector;health equity;Health Personnel;Health system;Health trends;Healthcare Systems;Hypertension;improved;Incidence;innovation;Joints;Link;Mental Depression;Modeling;Navajo;New Mexico;Outcome;Personal Satisfaction;Persons;Policies;Population;predictive modeling;Prevalence;prevent;promote resilience;prototype;Public Health;Readiness;Research;resilience;Risk;Risk Assessment;rural area;Sampling;Science;Shapes;Survivors;System;Testing;Time;tool;training data;United States Environmental Protection Agency;user-friendly;Vector-transmitted infectious disease;Visualization;Vulnerable Populations;Water Supply

PROJECT_TITLE: Environmental Disasters and Impacts on Health Care Systems


NIH_SPENDING_CATS: Cancer;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: LENG, SHUGUANG  (contact)

PROJECT_TERMS: Affect;Air;American;Animals;Area;Atmosphere;Cancer Center;cancer diagnosis;Cancer Patient;cancer survival;Cancer Survivor;cancer type;carcinogenesis;Carcinogens;causal model;Censuses;Cessation of life;Chronic;Climate;climate change;climate policy;climate-related health;Communication;Communities;community engagement;Contracts;Data;Death Rate;Decision Making;Etiology;fine particles;Fostering;Frequencies;Gastrointestinal tract structure;Genes;Goals;Growth;Health;Health Alliance;health literacy;Health Policy;Hormones;Human;improved;In Vitro;Incidence;Individual;Interdisciplinary Study;Knowledge;Link;Location;lung injury;Malignant Neoplasms;Mental Health;Midwestern United States;Modeling;mortality;Mutation;National Cancer Institute;neoplasm registry;Oncology;Organ;Outcome;particle;Persons;Population;population health;Premalignant Cell;Prognosis;Public Health;Pulmonary Heart Disease;Research;Research Personnel;Research Priority;Resolution;Risk;Science;Site;Smoke;Somatic Mutation;Testing;Time;toxicant;Translating;tumor;United States National Center for Health Statistics;Variant;Vulnerable Populations;Wildfire;Work

PROJECT_TITLE: Linking Wildfire Smoke to Cancer


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: GINOSSAR, TAMAR  (contact)

PROJECT_TERMS: Address;Affect;Air;Ally;American Indian Tribe;American Indians;Childhood;Climate;climate change;climate impact;climate-related health;Collaborations;Communication;Communities;community based participatory research;community center;community engaged research;community engagement;community partners;community research;Cultural Diversity;Decision Making;design;Disasters;dust storms;Ensure;Environment;Environmental Health;Environmental Science;evidence base;experience;Exposure to;food insecurity;Fostering;Funding;Geography;Goals;graduate school;Health;Health Alliance;health care availability;health data;health literacy;Health Professional;Healthcare;hispanic community;Hispanic Populations;Human;Income;indigenous community;Individual;Inequity;Knowledge;Latinx;literacy;marginalized population;Mediating;melting;member;Minority;minority communities;Mission;National Institute of Environmental Health Sciences;New Mexico;Outcome;Persons;Phase;Policies;pollutant;Poverty;Precipitation;Process;Public Health;Readiness;Research;Research Personnel;Research Priority;Research Project Grants;resilience;Risk Reduction;Rural;Rural Community;rural Hispanic;Science;Soil;Structure;Temperature;Training;Translating;Translational Research;tribal Nation;Trust;underserved community;Universities;Urban Community;vulnerable community;Water;Wildfire;Work

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: ZHANG, SU  (contact)

PROJECT_TERMS: 3-Dimensional;Agriculture;Air Pollution;built environment;Carbon Black;citizen science;climate change;climate impact;climate-related health;Collaborations;Communities;Community Actions;community engagement;Community Surveys;Complex;Consultations;Data;data acquisition;Data Analytics;data cleaning;data hub;data platform;Data Science;Data Set;data tools;data visualization;Disasters;Electronic Health Record;Employment;Environment;Environmental Monitoring;Floods;Future;Goals;Graph;graphical user interface;Health;Health Alliance;health data;Health protection;Health Sciences;Health Services;Health Services Accessibility;Health system;Healthcare Systems;Heterogeneity;Human;Hurricane;improved;Information Dissemination;Infrastructure;innovation;Interruption;laboratory experiment;Life Cycle Stages;Methodology;Methods;Modeling;Monitor;Natural Disasters;New Mexico;Online Systems;Outcome;Pattern;phase change;Physical environment;preservation;programs;promote resilience;Readiness;remote sensing;Reproducibility;Research;Research Design;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;resilience;Resource Sharing;Resources;Science;sensor;Series;Services;Social Environment;social stress;socioeconomics;Soil;Statistical Data Interpretation;Time;Training;Transportation;trend;Universities;Water;weather stations;web platform;Wildfire;Work

PROJECT_TITLE: Data Core