NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Genetic Testing;Genetics;Kidney Disease;Organ Transplantation;Prevention;Transplantation

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Living kidney donation is an effective treatment for selected patients with end-stage kidney disease (ESKD), but it is not without risks, and long-term health risks vary by race, sex, and age, and there is a lack of evidence-based guidelines for preserving renal function in living kidney donors (LKDs). This research project aims to inform recruitment methods and engage the community in a study which will identify predonation and postdonation risk factors, including genetic factors, associated with ESKD in LKDs. The study will have a significant impact on the care and well-being of LKDs, benefiting the large number of individuals who have already donated a kidney.

PI_NAMEs: LEVAN, MACEY LEIGH (contact)

PROGRAM_OFFICER_NAME: NORTON, JENNIFER MICHELLE

PROJECT_TERMS: Address;Age;Biological;Black race;Body mass index;career;Caring;Characteristics;Chronic Kidney Failure;Clinical;Cohort Studies;community advisory board;community engagement;comparison group;Counseling;Data;data registry;Dedications;disease diagnosis;disorder risk;effective therapy;End stage renal failure;Ethics;evidence base;evidence based guidelines;Feedback;General Population;Genes;Genetic;Genetic Counseling;genetic risk factor;genetic testing;Glomerular Filtration Rate;Health;Health behavior;improved;Individual;Informed Consent;innovation;Interview;Kidney;Kidney Transplantation;Knowledge;levan;Life;Life Style;Link;Living Donors;living kidney donor;male;Measures;Mediating;Medical;meetings;member;Methodology;Methods;mortality;Nephrectomy;Nephrons;novel;obesity development;Operative Surgical Procedures;Patient Selection;Patients;Personal Satisfaction;Persons;Population Heterogeneity;Positioning Attribute;preservation;Process;prospective;Qualitative Research;Race;Recommendation;recruit;Renal function;Research;Research Design;Research Project Grants;Risk;Risk Factors;risk prediction;screening;Series;sex;social;Structure;Time;tool;Trust;willingness;Work

PROJECT_TITLE: A Case-Cohort Study of Novel Determinants of Living Kidney Donor Risk

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHARLOTTESVILLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Racial disparities for Black Americans compared to White Americans have persisted in multiple aspects of chronic kidney disease (CKD), from incidence and prevalence to care and outcomes. This project will trace back to the period preceding CKD to identify root causes of these disparities. Understanding the sources of these disparities will serve to minimize them and improve the care and health outcomes of Black Americans in the U.S.

PI_NAMEs: SCIALLA, JULIA J;YAN, GUOFEN  (contact)

PROGRAM_OFFICER_NAME: ABBOTT, KEVIN C

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Adult;Affect;Age;Age of Onset;Alcohols;American;Area;Award;Back;Behavior;Black American;black patient;Black Populations;Black race;Caring;caucasian American;Censuses;Cessation of life;Chronic Kidney Failure;clinical risk;cohort;Communities;Community Surveys;County;Data;Data Pooling;Databases;Development;Diabetes Mellitus;Dimensions;Disease;disease disparity;Disease Outcome;Disparity;disparity elimination;End stage renal failure;Factor Analysis;Geography;Glomerular Filtration Rate;Health;High Prevalence;high risk;Hypertension;improved;Incidence;Individual;Inequity;Intervention;Kidney;Kidney Diseases;Knowledge;Life Style;Measures;Morbidity - disease rate;mortality;mortality risk;novel;Onset of illness;Outcome;Patients;peer;Persons;Population;Populations at Risk;Prevalence;Public Health;racial difference;racial disparity;Recommendation;Research;Risk;Risk Factors;risk selection;Selection Bias;Smoking;Socioeconomic Status;Source;Statistical Data Interpretation;Statistical Methods;Structural Racism;Text;Veterans;Work

PROJECT_TITLE: Disparities in kidney outcomes among Black and White people at risk for chronic kidney disease (CKD)

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Genetics;Kidney Disease

ORG_CITY: Columbus

ORG_DEPT: PHARMACOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Acute kidney injury is a common illness among hospitalized patients with high morbidity and mortality and a common cause of irreversible chronic kidney disease. Therapeutic strategies for treating acute kidney injury are currently unavailable. This application proposes studies to determine how NAD+/NADH imbalance contributes to renal injury and might be applied in the future to treat or prevent acute kidney injury.

PI_NAMEs: KIM, JIYOUNG  (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Acetylation;Acute Renal Failure with Renal Papillary Necrosis;Address;Anabolism;C-Terminal Binding Protein 1;C-Terminal Binding Protein 2;Cardiovascular system;Cell Death;Cell Physiology;ChIP-seq;chromatin immunoprecipitation;Chronic Kidney Failure;Cisplatin;Clinical;clinical translation;Complication;Data;Death Rate;Development;Disease;End stage renal failure;Energy Metabolism;Enzymes;EP300 gene;Epithelial Cells;Functional disorder;Future;gene repression;Generations;Genes;genetic corepressor;Genetic Transcription;Genome;Goals;Health;Hospitalization;Impairment;Incidence;Injury to Kidney;insight;Intensive Care Units;Ischemia;Kidney;kidney cell;Kidney Diseases;kidney preservation;Knowledge;Length of Stay;Mediating;Mediator;Metabolic;metabolic rate;Metabolic stress;Metabolism;metabolomics;Mitochondria;Molecular;Molecular Target;Morbidity - disease rate;mortality;mouse model;Multienzyme Complexes;Mus;N-terminal;NADH;nephrotoxicity;Nicotinamide adenine dinucleotide;novel;novel therapeutic intervention;Nuclear;Oncology;Outcome;Pathogenesis;Pathogenicity;Patients;pharmacologic;Play;prevent;Prevention;progression risk;protein expression;Publishing;Regulation;renal epithelium;Renal function;Renal Tissue;Renal tubule structure;Research;respiratory;Respiratory Chain;Rhabdomyolysis;Risk;RNA interference screen;Role;sensor;Sepsis;Severities;Signal Pathway;Site-Directed Mutagenesis;Stress;stressor;Syndrome;Testing;Therapeutic;therapeutic target;therapeutically effective;Transcription Repressor;Tubular formation;Up-Regulation

PROJECT_TITLE: The role of transcriptional corepressor CtBP2 as a metabolic sensor in acute kidney injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-W(04)]


NIH_SPENDING_CATS: Cardiovascular;Kidney Disease

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Each year in the US, more than 500,000 patients requiring hemodialysis undergo a surgical procedure to establish an arteriovenous fistula (AVF), the safest and most efficient means of vascular access. Regrettably, these AVFs experience a 50% failure rate within six months. Our objective is to develop innovative strategies to mitigate this high failure rate.

PI_NAMEs: BAHNSON, EDWARD M (contact)

PROJECT_TERMS: 3-Dimensional;Address;Anti-Inflammatory Agents;Antiinflammatory Effect;antioxidant therapy;Antioxidants;Arteriovenous fistula;Balloon Angioplasty;Blood flow;Blood Vessels;calponin;Catheters;Clinical;clinically relevant;Dependence;Dialysis procedure;Diameter;Disease;economic cost;effective therapy;experience;Failure;Fluorescence Microscopy;Genes;Hemodialysis;hemodynamics;Histologic;Hyperplasia;improved;In Vitro;in vivo;Infection;infection risk;Injury;innovation;Intervention;Kidney Failure;Kidney Transplantation;Legal patent;Light;Limb structure;migration;Modeling;Morbidity - disease rate;morphometry;mouse model;Mus;myocardin;novel therapeutics;nuclear factor-erythroid 2;Operative Surgical Procedures;Oxidation-Reduction;Oxidative Stress;Oxidative Stress Pathway;Pathway interactions;Patients;Phenotype;phenotypic biomarker;Play;Process;Proliferating;Quality of life;Regulation;Renal dialysis;Role;Smooth Muscle Myocytes;Stenosis;Terpenes;Therapeutic;Therapeutic Intervention;transcription factor;Uremia;vascular injury;Vascular Smooth Muscle;Veins;Venous;Vimentin

PROJECT_TITLE: Differential redox regulation of vein and arterial smooth muscle cells in AVF stenosis

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Genetics;Kidney Disease;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Autosomal dominant tubulointerstitial kidney disease due to uromodulin mutations (ADTKD-UMOD), a leading genetic kidney disease, causes autophagy failure and progressive chronic kidney disease. The goal of this project is to dissect the role of a novel endoplasmic reticulum protein in autophagy in ADTKD.

PI_NAMEs: CHEN, YING MAGGIE (contact)

PROJECT_TERMS: Address;Astrocytes;Autophagocytosis;autosome;Award;Cell Death;Cell model;Cells;Chronic Kidney Failure;CRISPR/Cas technology;Deletion Mutation;Disease;Disease Progression;Endoplasmic Reticulum;endoplasmic reticulum stress;Epithelial Cells;Exclusion;Failure;Functional disorder;Gene Mutation;Genetic;genetic variant;Goals;Hereditary nephritis;Human;Impairment;Inherited;innovation;Kidney;Kidney Diseases;Kidney Failure;kidney fibrosis;Limb structure;Mediating;Medical;Modeling;Molecular;mouse model;mutant;Mutation;neurotrophic factor;novel;novel therapeutic intervention;Patients;Polycystic Kidney Diseases;Protein Secretion;Proteins;Renal function;Research;Role;targeted treatment;Testing;therapeutically effective;Thick;Tubular formation;UMOD gene;Variant

PROJECT_TITLE: Develop Autophagy Activators to Treat Autosomal Dominant Tubulointerstitial Kidney Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-L(91)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BIRMINGHAM

ORG_NAME: BIRMINGHAM VA MEDICAL CENTER

ORG_STATE: AL

PHR: The rate of suicide among US military Veterans is approximately 50% higher than among non-Veterans. Suicide is a complex phenomenon that is highly associated with social determinants of health (SDH) including housing instability, justice involvement, and unemployment. Using existing Department of Veterans Affairs (VA) administrative data, and environmental scan of VA support programs, and qualitative interviews with VA support program staff and Veterans, this study will determine whether and how services to address SDH mitigate Veterans’ risk of suicide. Results will lay the groundwork to develop implementation trials to bolster VA and community social support services as non-medical components of suicide prevention for Veterans.

PI_NAMEs: MONTGOMERY, ANN ELIZABETH (contact);TRUE, JENNIFER GALA

PROJECT_TERMS: acceptability and feasibility;Address;Age;Area;Biological Factors;Cessation of life;Clinical;Communities;comorbidity;Complex;Data;Depression screen;design;Detection;Diagnosis;Disparity;Economics;Employment;experience;Experimental Designs;Goals;Health;health care service utilization;Health Services Administration;Healthcare Systems;Homelessness;housing instability;implementation trial;improved;informant;Infrastructure;innovation;Integrated Health Care Systems;Intervention;Interview;Justice;Legal;lens;Literature;Maps;Medical;Medical center;Medical Records;Mental Depression;Mental Health;Methodology;Methods;military veteran;Natural experiment;operation;Outpatients;Pain Disorder;Patients;Perception;Persons;Population;Predictive Analytics;prevent;Prevention;prevention practice;Prevention strategy;programs;Provider;Public Health;Questionnaires;Recording of previous events;Research;Scanning;Self-Injurious Behavior;service uptake;Services;social factors;social health determinants;Social isolation;Social support;Social Work;Structure;suicidal;suicidal morbidity;suicidal risk;Suicide;suicide mortality;Suicide prevention;suicide rate;System;Telephone Interviews;Testing;Thinking;tool;Training;Unemployment;United States;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;Violence;Visit;Work

PROJECT_TITLE: Can services to address Veterans social determinants of health reduce their suicide risk?

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


ORG_CITY: DURHAM

ORG_NAME: DURHAM VA MEDICAL CENTER

PHR: Significance: The proposed project could rapidly accelerate a promising new treatment for chronic complex TBI that is supported by strong preliminary data and builds upon compelling research findings. If allopregnanolone (ALLO) is efficacious and well-tolerated in this population, a larger Phase 2 or Phase 3 randomized controlled trial (RCT) would be the next logical step for this molecule - which has the potential to address an urgent unmet clinical need for Veterans with chronic complex TBI and commonly co-occurring conditions such as depression and pain symptoms, and to positively impact functional outcome and quality of life in this population. A longer-acting formulation of ALLO is also a possibility and under development in our laboratory. In the interim, the proposed pilot RCT using intravenous ALLO would provide critical pharmacokinetic data in this chronic complex TBI cohort, in addition to potential initial clinical signals for therapeutic efficacy and biomarker candidate identification to inform future efforts.

PI_NAMEs: MARX, CHRISTINE E. (contact)

PROJECT_TERMS: Acceleration;Address;Aftercare;Allopregnanolone;Analgesics;anti-depressive agents;Anti-Inflammatory Agents;antidepressant effect;Antiinflammatory Effect;arm;Behavior assessment;Biological Markers;Blood;Brain;Brief Pain Inventory;C-reactive protein;candidate identification;Chronic;Clinical;Clinical Data;clinical predictors;cohort;Complex;Cyclodextrins;cytokine;Data;depressive symptoms;Development;Dimensions;Dose;Drug Kinetics;efficacy evaluation;Electrocardiogram;Exhibits;Formulation;four-arm study;functional improvement;functional outcomes;Future;Goals;gray matter;Hamilton Rating Scale for Depression;heart rate variability;Hour;human data;improved;Inflammatory;inflammatory marker;Infusion procedures;Intervention;Intravenous;Laboratories;Magnetic Resonance Imaging;Mass Spectrum Analysis;Mental Depression;mild traumatic brain injury;Monitor;Musculoskeletal Pain;nanomolar;Neurobiology;neuroimaging;neuroprotection;neurosteroids;novel;Pain;Pain Disorder;pain symptom;Participant;Patients;Phase;Placebos;Population;pre-clinical;primary endpoint;Property;Quality of life;Randomized;Randomized, Controlled Trials;Recording of previous events;regenerative;regenerative therapy;Reporting;Research;Research Personnel;response;Rodent Model;secondary endpoint;Serum;SF-36;Signal Transduction;Symptoms;Therapeutic;therapeutic biomarker;therapeutic candidate;Thick;Treatment Efficacy;Veterans

PROJECT_TITLE: Novel Regenerative Therapeutic in Chronic Complex TBI

STUDY_SECTION_NAME: Brain Health and Injury[RRD1]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Autoimmune Disease;Cancer;Lung;Lung Cancer;Pulmonary Fibrosis;Rare Diseases;Scleroderma

ORG_CITY: CINCINNATI

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: PROJECT NARRATIVE Patients diagnosed with Scleroderma (SSc), a disease resulting in the progressive scarring of the skin and lungs, have a significantly increased risk of lung cancer, or Cancerous Scleroderma (CSc). The main cell type that is responsible for this severe scarring promotes the development of lung cancer in SSc patients, hence this research aims to uncover ways to target these pathogenic cells to resolve CSc. There is no currently established treatment to reverse scarring in any organ, therefore the impact of the novel insights gained from this research will be tremendous.

PI_NAMEs: BRECKENRIDGE, JOEY EMERY (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: A549;Actins;Adenocarcinoma Cell;Affect;aged;Aging;airway remodeling;Antineoplastic Agents;Apoptosis;Autoimmune;Automobile Driving;bench to bedside;beta-Galactosidase;Cancerous;Cause of Death;CD8-Positive T-Lymphocytes;CDKN2A gene;cell growth;cell injury;cell type;Cells;Chronic;Cicatrix;Collagen;Connective Tissue Diseases;Cyclin-Dependent Kinase Inhibitor;cytokine;Data;Deposition;Diagnosis;Disease;Engraftment;Enzymes;Epithelial Cells;Etiology;Extracellular Matrix;Fibroblasts;Fibrosis;gain of function;Goals;Growth;Growth Factor;high voltage electron microscopy;Human;human disease;Hypertrophy;idiopathic pulmonary fibrosis;Immunofluorescence Immunologic;In Vitro;in vivo;Inflammation;innovation;insight;knock-down;Knowledge;Light;Link;loss of function;Lung;Lung Adenocarcinoma;lung development;Malignant neoplasm of lung;Malignant Neoplasms;member;Modeling;Molecular;Monitor;Morbidity - disease rate;Mus;muscle hypertrophy;Myofibroblast;Neoplasms;novel;novel therapeutics;old mice;Organ;Organoids;Outcome;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;permissiveness;Play;Production;Publishing;Pulmonary Fibrosis;receptor;Reporting;Research;Rheumatism;Risk;Risk Factors;Role;Scleroderma;senescence;senescence associated secretory phenotype;senescent cell;Signal Transduction;Skin;Smooth Muscle;Stains;Stromal Cells;Sudan Black B;System;Systemic Scleroderma;Technology;Testing;therapeutic candidate;Time;TNF gene;transcriptome sequencing;Transforming Growth Factor beta;Translating;Trichrome stain method;tumor;tumor growth;Tumor Immunity;Tumor Promotion;tumorigenesis;tumorigenic;validation studies

PROJECT_TITLE: Targeting fibrosis to change cancer outcomes


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases

ORG_CITY: ATLANTA

ORG_NAME: EXVADE BIOSCIENCE, INC.

ORG_STATE: GA

PHR: Project Narrative Glioblastoma Multiforme (GBM) is a highly aggressive form of brain cancer with a fatality rate close to 100% despite aggressive therapies, primarily because the invasive nature and inaccessibility of the tumors makes recurrence after treatment very common and treatment efficacy hard to assess. We have developed a system that can provide serial direct tissue biopsy of the tumor, allowing for collection of data about the tumor genetic profile and treatment efficacy that will allow clinicians to make more informed decisions about treatment course and accelerate entrance into suitable clinical trials. This information will empower clinicians by giving them access to an unprecedented level of information about tumor response to treatment in real time, allowing them to enhance the effectiveness of current treatments, increase the efficiency of clinical trials, and finally improve GBM outcomes that have not changed in decades.

PI_NAMEs: MEEHAN, SEAN  (contact)

PROGRAM_OFFICER_NAME: EVANS, GREGORY

PROJECT_TERMS: Acceleration;active method;Adoption;Aftercare;aggressive therapy;Award;biomaterial compatibility;Biopsy;Blood - brain barrier anatomy;Brain Neoplasms;Catheters;cell motility;Cells;Chemotherapy and/or radiation;Clinical;clinical translation;Clinical Treatment;Clinical Trials;clinically relevant;copolymer;Data;Data Collection;Death Rate;design;Device Designs;Device or Instrument Development;Devices;diagnostic tool;Diffuse;Disease;Disease Management;Drug Screening;effective therapy;Effectiveness;efficacy evaluation;Emerging Technologies;empowerment;Engineering;Ensure;Excision;Fatality rate;first-in-human;Foundations;Funding;Genetic;Glioblastoma;Grant;Heterogeneity;Human;Image;imaging capabilities;Implant;implantation;improved;improved outcome;In Vitro;in vivo;Individual;Information Management;insight;Instruction;interest;International;Intervention;Lead;liquid biopsy;Malignant neoplasm of brain;Marketing;meetings;Methods;migration;Molecular;Molecular Profiling;Monitor;nanofiber;nanopolymer;Nature;Needles;neoplastic cell;novel;Operative Surgical Procedures;Outcome;Outpatients;Patient-Focused Outcomes;Patients;Performance;Phase;Polyurethanes;Positioning Attribute;pre-clinical;preclinical development;Preclinical Testing;Preparation;Primary Neoplasm;Process;Production;Publishing;Puncture biopsy;Qualifying;radiological imaging;Recording of previous events;Recurrence;Recurrent tumor;response;Risk;Rodent;Rodent Model;Safety;safety and feasibility;Sampling;Silicones;Speed;standard of care;subcutaneous;Suggestion;survival outcome;Survival Rate;System;Technology;Testing;Thinness;Time;Tissues;Translations;Treatment Efficacy;Treatment outcome;treatment planning;Treatment Protocols;treatment response;tumor;tumor heterogeneity;tumor progression;Tumor Tissue;Uncertainty;United States National Institutes of Health;usability;virtual

PROJECT_TITLE: Tumor Monorail Device for Serial Glioblastoma Biopsy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-S(11)B]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PI_NAMEs: KAST, WIJBE MARTIN (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Administrative Supplement;anti-cancer research;Antibodies;Basic Cancer Research;Basic Science;Biological Markers;Breast;Breast Cancer Model;Breast Melanoma;Budgets;cancer cell;Cancer Center Support Grant;cancer clinical trial;Cancer Control;cancer immunotherapy;Cancer Patient;cancer prevention;Cancer Vaccines;CD8B1 gene;Cell Separation;Cell surface;Cell Therapy;Cells;Charge;chemoradiation;chemotherapy;Chromatin Loop;Clinical;Clinical Research;Clinical Sciences;Clinical Trials;Clinical Trials Cooperative Group;Clustered Regularly Interspaced Short Palindromic Repeats;Color;Complex;Comprehensive Cancer Center;Consultations;Copy Number Polymorphism;Correlative Study;cost;cost effective;Cytometry;cytotoxic;Data;Diagnostic;Diet;Direct Costs;Disease Outcome;Doctor of Philosophy;Education;ENG gene;epigenomics;Equipment;Faculty;Fasting;Feedback;Flow Cytometry;Fluorescence;Foundations;Funding;Genome;Genomics;Genomics Shared Resource;Grant;Gynecologic Oncology Group;Heterogeneity;high throughput analysis;Immune;Immune checkpoint inhibitor;immune function;Immunologic Monitoring;immunological status;Immunologics;immunoregulation;Immunotherapy;immunotherapy clinical trials;improved;Institution;instrument;ipilimumab;Laboratories;Last Name;Local Therapy;Malignant - descriptor;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mediating;member;mesenchymal stromal cell;Methods;Mission;Molecular;mutant;Names;Natural Killer Cells;Neoplasm Circulating Cells;Neuroblastoma;Oncology;Outcome;Pathogenesis;Pathology;Patients;Peer Review;Phenotype;Population;pre-clinical;programs;prostate cancer risk;Proteins;Publications;Regulation;Reporting;Research;Research Design;Research Personnel;Research Support;Resolution;Resource Sharing;response;Role;satisfaction;Services;Sorting;Surveys;System;T cell clonality;Technology;Therapeutic;Training and Education;transcriptome sequencing;translational cancer research;Translational Research;Tropism;tumor heterogeneity;tumor microenvironment;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;Underrepresented Populations;University of Southern California Norris Cancer Center;vector

PROJECT_TITLE: Flow Cytometry Core


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prevention

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE: OVERALL There were an estimated 1.7 million new cases of cancer in the United States in 2018, and an estimated 609,000 deaths from the disease. Cancer is the second leading cause of the death in the U.S. The goal of the Fred Hutchinson/University of Washington Cancer Consortium is the elimination of cancer as a cause of suffering and death through more effective prevention, diagnosis, and treatment, deriving from fundamental insights into the biology of the disease.

PI_NAMEs: LYNCH, THOMAS JAMES (contact)

PROJECT_TERMS: Alaska;anti-cancer research;Area;base;Biology;Cancer Biology;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Detection;cancer diagnosis;Cancer Etiology;cancer therapy;carcinogenesis;Carcinogenesis Mechanism;Caregivers;Catchment Area;Cause of Death;Cessation of life;Child;Childhood;Clinical;clinical care;clinical practice;Clinical Research;Collaborations;Communities;Comprehensive Cancer Center;Computational Biology;computer studies;County;Development;Diagnosis;Diagnostic;Discipline;Disease;Educational process of instructing;Enrollment;Ensure;epigenomics;Equation;Equity;Exposure to;Faculty;Faculty Recruitment;Fostering;Funding;Genomics;Goals;graduate student;Grant;Health;Health Sciences;Hematopoietic Stem Cell Transplantation;host neoplasm interaction;Idaho;Immunology;Immunotherapeutic agent;improved;Individual;insight;Institution;inter-institutional;interdisciplinary collaboration;interest;Intervention;Investments;Knowledge;Laboratories;Laboratory Research;Leadership;Malignant Neoplasms;Measures;member;Mentors;Mission;Molecular;Montana;mortality;multidisciplinary;next generation;Outcome;outreach;pathogen;Patients;Peer Review;Population Research;Postdoctoral Fellow;Prevention;Prevention strategy;Primary Prevention;profiles in patients;programs;Public Health;Quality of Care;Research;Research Infrastructure;Research Personnel;Resources;Risk Factors;Risk Marker;Science;Secondary Prevention;Students;synthetic biology;targeted treatment;Therapeutic;therapy development;Training;Training and Education;Translating;Translational Research;Translations;Transplantation;treatment center;treatment trial;tumor;tumor metabolism;tumor progression;Underrepresented Populations;United States;Universities;Washington;Work;Wyoming

PROJECT_TITLE: Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Microbiome

ORG_CITY: AMES

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: PROJECT NARRATIVE This project aims to define the function and biological significance of a class of peptides (RaS-RiPPs) produced by oral Streptococci, and to examine their impact on the human oral microbiota. Understanding how these compounds modulate the oral microbiome and the activity of their own host species represents an important gap in knowledge concerning one of the major groups of oral microorganisms. In turn, these data will provide a foundation for examining their impact on the host and oral niche.

PI_NAMEs: RUED, BRITTA  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Achievement;Address;Adverse effects;Affect;Architecture;Award;Bacteria;Behavior;Biological;Biotinylation;career;Cells;Chemical Structure;Chicago;Co-Immunoprecipitations;Collaborations;Communities;comparative;Complex;Data;Dental caries;Disease;dysbiosis;Environment;Epithelial Cells;Equilibrium;experimental study;Faculty;Family;Foundations;Genetic Screening;Genetic Transcription;Goals;Growth;Health;Home;Human;Illinois;Immunobiology;In Vitro;Infective endocarditis;Institution;Investigation;Knowledge;Laboratory Research;Luciferases;member;Metagenomics;metatranscriptomics;Methods;Microbe;microbiome;microorganism;Mutagenesis;novel;Operon;opportunistic pathogen;Oral;oral cavity epithelium;oral commensal;Oral health;oral microbial community;oral microbiome;oral pathogen;oral streptococci;Organism;Peptide Biosynthesis;peptide chemical synthesis;Peptides;Phase;Positioning Attribute;Process;Production;Productivity;programs;Proteins;Proteomics;Quantitative Reverse Transcriptase PCR;quorum sensing;Reporter;Research;Research Personnel;response;Ribosomes;S-Adenosylhomocysteine;S-Adenosylmethionine;Secure;Streptococcus;Streptococcus ferus;Streptococcus mitis;Streptococcus mutans;Streptococcus oralis;System;Training;transcriptome sequencing;transcriptomics;Universities;Virus;Western Blotting;Work

PROJECT_TITLE: Determining the mechanism and impact of streptococcal RaS-RiPPs on the human oral microbiome

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: IRVINE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Transposable elements are prevalent selfish DNA sequences present in many organisms, and they constitute about 45% of the human genome. Their activity and abundance are related to their ability to cause inherited diseases and cancers, including breast cancer, colon cancer, and leukemia. The proposed research will identify factors that influence the abundance of transposable elements and determine their consequences on host function and fitness, with strong implications for human health and disease states.

PI_NAMEs: LEE, GRACE YUH CHWEN (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: 3-Dimensional;Affect;Biochemical;Cellular biology;chromatin modification;Colon Carcinoma;comparative;Disease;DNA;DNA Insertion Elements;DNA Sequence;DNA Transposable Elements;Drosophila genus;Epigenetic Process;Evolution;Exhibits;Fertility;fitness;Genes;Genetic;Genetic Processes;Genome;genome-wide;Genomics;Goals;Health;Hereditary Disease;Human;Human Genome;Inherited;Laboratories;leukemia;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Modeling;Molecular;novel;Nuclear;Organism;Parasites;Persons;Positioning Attribute;programs;Research;RNA;Role;Salamander;Selfish DNA;Shapes;species difference;Structure;Tetraodontidae;Variant;vertebrate genome

PROJECT_TITLE: How transposable elements drive genome evolution through epigenetic mechanisms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-U(55)R]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Eating Disorders;Mental Health;Mental Illness;Nutrition;Pediatric;Prevention

ORG_CITY: LOUISVILLE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: PROJECT NARRATIVE This project will collect data on early childhood risk factors for eating disorders in female children ages 6-12. The proposed research has significant public health relevance, as it will enhance our understanding of how eating disorders develop and for whom, leading to early detection and prevention efforts. The proposed research is relevant to NIMH’s strategic aim 3.1. A to strive for prevention based on an understanding of risk, as it will lead to tools that can better identify early risk factors, as well as prevention efforts directly targeting mechanisms predictive of the onset of early eating disorders and related pathology.

PI_NAMEs: BUFFERD, SARA J;LEVINSON, CHERI ALICIA (contact)

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: 12 year old;Adolescence;Adolescent;Age;Age of Onset;Anxiety;Anxiety Disorders;Behavior;Behavioral;bodily sensation;body dissatisfaction;Body Size;Brain;Cessation of life;Characteristics;Child;Childhood;childhood anxiety;Chronic;Clinical;Cognition;Cognition Disorders;Cognitive;cohort;Control Groups;cost;Data;Death Rate;design;Development;Diagnosis;Diagnostic;dieting;Down's Syndrome;early adolescence;early childhood;Early Diagnosis;Early identification;Early Intervention;early onset;Eating;Eating Behavior;Eating Disorders;Esthesia;Etiology;Exhibits;experience;Extinction;Family;Fasting;Female;follow-up;Fright;gastrointestinal system;girls;Goals;Health;High Prevalence;high risk;Hyperphagia;Hypersensitivity;Impairment;improved;Individual;innovation;insight;Interoception;Knowledge;Lead;Learning;Link;Literature;Malignant Neoplasms;maternal anxiety;Mental Depression;Mental disorders;multimodality;National Institute of Mental Health;negative affect;Non-Insulin-Dependent Diabetes Mellitus;novel;Occupations;Onset of illness;opioid use;Parents;Pathology;Physiological;Population;Predisposing Factor;Prevention;Prevention program;prospective;public health relevance;Recording of previous events;recruit;Reporting;Research;restraint;Risk;Risk Factors;Sampling;social anxiety;societal costs;Societies;standard care;Sudden infant death syndrome;Symptoms;Testing;theories;Time;tool;Traction;United States;Work;Youth

PROJECT_TITLE: Anxiety and Interoception Risk for Eating Disorders in Childhood

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: HL

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: PROJECT NARRATIVE There is an unmet clinical need to adjust the number and location of the acquired echocardiographic planes, which is crucial for assessment of heart valves, strain imaging and cardiac fluid dynamics enabled by multiplanar echocardiographic particle image velocimetry (MP-Echo-PIV). This project aims to devise a novel generation of 4D transthoracic echocardiography (4D TTE) systems using matrix arrays with a beamformer to enable operator- controlled multiplanar acquisition at high volume-rates. These latest systems will accommodate accurate assessment of blood flow patterns in the heart through high-speed multiplanar acquisitions.

PI_NAMEs: KHERADVAR, ARASH ;YEN, JESSE T-P (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: 3-Dimensional;4D Imaging;Algorithms;Anatomy;Blood;Blood flow;Breast;Cardiac;cardiac magnetic resonance imaging;Clinical;Clinical assessments;clinical diagnosis;cohort;Complex;Computer software;congenital heart abnormality;contrast imaging;design;Detection;Echocardiography;electric impedance;Elements;Four-Dimensional Echocardiography;Frequencies;Generations;Goals;Heart;Heart Valve Diseases;Heart Valves;Image;improved;In Vitro;Lasers;Liquid substance;Location;Measurement;Measures;Methods;Microbubbles;Modernization;Motion;multidisciplinary;Myocardial;novel;particle;Patients;Pattern;Physiologic pulse;Prostate;prototype;pulmonary arterial hypertension;reconstruction;Reproducibility;Right Ventricular Dysfunction;Right ventricular structure;Sampling;Scanning;second harmonic;Signal Transduction;Speed;System;Technology;temporal measurement;Three-Dimensional Echocardiography;Time;Tissues;Transducers;transmission process;Tricuspid Valve Insufficiency;ultrasound;usability;vector;Velocimetries;Visualization

PROJECT_TITLE: High-speed 4D echocardiography system with adjustable multi-planar acquisition

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: CHICAGO

ORG_DEPT: ORTHOPEDICS

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: The proposed research is relevant to public health because improving the longevity of total knee arthroplasty would help the over 750,000 patients undergoing knee replacement annually by ultimately helping to delay or avoid revision surgeries. The proposed research is relevant to the NIH mission by 1) reducing the burden of human disability by improving the quality of life of total knee arthroplasty patients and 2) reducing the cost of medical care by preventing revision surgery.

PI_NAMEs: LUNDBERG, HANNAH JEAN (contact);POURZAL, ROBIN A.;VAN CITTERS, DOUGLAS W

PROGRAM_OFFICER_NAME: WANG, XIBIN

PROJECT_TERMS: absorption;Acceleration;Address;Age;base;Behavior;Chemical Structure;Chemicals;clinical diagnosis;Code;cohort;comorbidity;cost;crosslink;Data;demographics;design;Diabetes Mellitus;Diagnosis;disability;Dose;economic cost;Environment;Evaluation;Failure;Finite Element Analysis;Goals;Histopathology;Hospital Charges;Human;Image;Implant;implant design;improved;In Situ;in vivo;Inflammation;Inflammatory Response;innovation;insight;knee mechanics;knee replacement arthroplasty;light microscopy;Link;Lipids;Longevity;Macrophage;Maps;mechanical properties;Mechanics;Medical Care Costs;Methods;Mission;Modeling;Molecular;novel;Operative Surgical Procedures;Osteolysis;Outcome;oxidation;particle;Particulate;Pathologist;Pathway interactions;Patients;Personal Satisfaction;Polyethylenes;pre-clinical;preclinical evaluation;Preclinical Testing;prevent;Procedures;Process;Property;Public Health;Quality of life;radiological imaging;repository;Research;response;Retrieval;Risk Factors;sample fixation;Scanning;Second Look Surgery;sex;simulation;Spatial Distribution;spectroscopic imaging;Spectroscopy, Fourier Transform Infrared;Spottings;Structure;Surface;Surgeon;Techniques;Technology;Testing;Time;Tissues;ultra-high molecular weight polyethylene;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: In vivo chemical changes of contemporary polyethylene in TKA: implications for wear and osteolysis

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Machine Learning and Artificial Intelligence;Physical Activity;Pulmonary Hypertension

ORG_CITY: NEW HAVEN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative To truly understand the value of MRI in guiding decisions about heart-failure with preserved ejection fraction, we will develop and test MRI methods similar to echocardiography in measuring elevated pressures in the heart. One method evaluates flow in leaky heart-valves (called regurgitation), using a constantly moving slice that zeros in on the heart-valve region. We develop a feasible method for evaluating the pressure in the heart, at rest and with exercises such as hand-grip, and determine their accuracy in patients, by comparing to the best available values (pressures obtained by catheterization).

PI_NAMEs: PETERS, DANA C (contact)

PROJECT_TERMS: 4D MRI;Anatomy;Blood;Breathing;Cardiac;Cardiac Catheterization Procedures;cardiac magnetic resonance imaging;Catheterization;Clinical;cohort;congenital heart abnormality;cost;Data;Death Rate;deep learning;Development;Devices;Diagnosis;Diastole;Dyspnea;Echocardiography;EFRAC;Evaluation;Exercise;Exercise Test;Functional disorder;Future;Goals;Gold;Heart;Heart Atrium;Heart Diseases;Heart failure;Heart Valves;hemodynamics;human subject;Image;Implant;improved;innovation;Lead;learning network;Left;Lung;Magnetic Resonance Imaging;Measurement;Measures;Methods;Mitral Valve;Monitor;Myocardium;novel strategies;Patients;Phase;Physiologic intraventricular pressure;Population;Positioning Attribute;preservation;pressure;pressure sensor;Protocols documentation;prototype;Proxy;pulmonary arterial pressure;Pulmonary Capillary Wedge Pressure;Pulmonary Hypertension;Relaxation;Reproducibility;Resolution;Rest;Scanning;Slice;standard of care;Stress;Systole;Techniques;Testing;Time;tool;Tricuspid valve structure

PROJECT_TITLE: MRI Metrics of Diastolic Dysfunction at Rest and Stress Validated by Estimated Pressures

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-N(03)M]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_NAME: NEW YORK GENOME CENTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE Preserving the genetic privacy of participants in research studies is critical for maintaining the trust of participants thus increasing study participation, as well as for enabling data sharing, thus facilitating important biomedical discoveries. The ability to accomplish this goal requires the development of efficient privacy-preserving tools. In order to keep up with the changing legal landscape and undisruptive access to analysis and protect patients' and research participants' privacy, our long term goal is to create a privacy-enhancing, cloud-ready, user-friendly, evolving, and modular omics tool ecosystem, which can be adapted to new data modalities and analysis needs as they arise.

PI_NAMEs: GURSOY, GAMZE  (contact)

PROGRAM_OFFICER_NAME: MORALES, JOANNELLA

PROJECT_TERMS: Address;Adopted;Algorithms;Alleles;Arithmetic;ATAC-seq;Atlases;Authorization documentation;Bar Codes;Benchmarking;Bioinformatics;Biological;Cells;ChIP-seq;Cloud Computing;Computer software;Conflict (Psychology);cryptography;Data;data access;Data Analyses;data modalities;Data Set;data sharing;Democracy;design;Development;Disease;diverse data;Ecosystem;encryption;experimental study;Future;Gene Expression;Gene Expression Profiling;Generations;Genes;Genetic;Genetic Privacy;genomic locus;Genomics;Genotype;Goals;Health;Human;Human BioMolecular Atlas Program;human data;indexing;Individual;Institution;Investigation;large scale data;Legal;Literature;Maps;Mathematics;Medical;Methods;Mind;Mining;Molecular;multiple datasets;next generation sequencing;novel;novel strategies;open source;operation;Participant;patient privacy;Patients;Phenotype;Policies;preservation;prevent;Privacy;privacy preservation;privacy protection;Process;Quantitative Trait Loci;rapid growth;Reproducibility;Research;Research Personnel;research study;Resources;Salmon;Sampling;Scientist;Series;single-cell RNA sequencing;Techniques;Technology;Text;Tissues;tool;Transcript;transcriptome sequencing;transcriptomics;Trust;United States National Institutes of Health;user-friendly

PROJECT_TITLE: Privacy Preservation in Transcriptomic Data Analysis

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Kidney Disease;Pancreatic Cancer;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

ORG_STATE: PA

PHR: Project Narrative  This supplement project seeks to evaluate a new series of compounds that have been developed to correct germline mutations in the von Hippel-Lindau (VHL) tumor suppressor, which predispose individuals to multiple forms of cancer. Using the CP4.29 compound and a series of related analogs, we will create and employ cell models expressing common germline mutations in VHL, and assess the ability of the compounds to repair the pro-oncogenic effect of the mutations. If successful, the resulting data will inform the further development of these compounds to intercept cancers in patients with germline VHL mutations.

PI_NAMEs: CLAPPER, MARGIE L. (contact)

PROGRAM_OFFICER_NAME: GUNASEKHARAN, VIGNESH KUMAR

PROJECT_TERMS: analog;Binding;Binding Sites;Biological;cancer prevention;cancer risk;Cell Line;Cell model;Central Nervous System;Clear cell renal cell carcinoma;Complex;Computer Models;Cyst;Data;Development;experimental study;Fox Chase Cancer Center;Functional disorder;Generations;Genes;Genetic;Genetic Transcription;Germ Lines;Germ-Line Mutation;Goals;hemangioblastoma;Hemangioma;Heritability;Hypoxia;Individual;Intercept;Kidney;Laboratories;Lead;Li-Fraumeni Syndrome;Literature;Malignant neoplasm of pancreas;Malignant Neoplasms;Membrane Proteins;Methods;Missense Mutation;Modeling;Molecular Conformation;mutant;Mutate;Mutation;novel;novel strategies;Oncogenic;Output;Pancreas;Pathogenicity;Patients;programs;protein function;Proteins;repaired;Retina;Risk;Series;Site;small molecule;Solubility;Somatic Mutation;Structure;targeted agent;Tertiary Protein Structure;Testing;Tissues;TP53 gene;transcription factor;Tumor Suppressor Proteins;ubiquitin-protein ligase;Variant;VHL mutation;VHL protein;Von Hippel-Lindau Syndrome;Work

PROJECT_TITLE: Refolding Mutant p53: A Strategy for Cancer Prevention in Li-Fraumeni Syndrome


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: ATHENS

ORG_NAME: LECTENZ BIO, INC.

PHR: PROJECT NARRATIVE Because altered glycosylation is a signature of many diseases, including cancer, infection, and neurodegenerative disorders, there is a need for reagents with high affinity and specificity for detecting glycans. We will optimize the specificity of Fbs1 for glycopeptides and glycoproteins that contain asparagine- linked (N-linked) carbohydrate chains using computationally-guided directed evolution. The resulting reagent will have broad utility in glycoscience research, including glycomics and glycoproteomics.

PI_NAMEs: WU, SHENG-CHENG  (contact)

PROGRAM_OFFICER_NAME: VONKOLLMAR, DESIREE

PROJECT_TERMS: Address;advanced analytics;Affinity;Affinity Chromatography;Antibodies;Antibody Response;Antigens;Asparagine;Bacteria;Binding;Binding Proteins;Biological;Biological Assay;Biological Markers;Biological Process;carbohydrate binding protein;carbohydrate receptor;Carbohydrates;Cell Extracts;Cells;Complex;Computer Models;design;Detection;Development;Diagnostic Reagent Kits;Directed Molecular Evolution;Disease;Engineering;Enzyme-Linked Immunosorbent Assay;Enzymes;Escherichia coli;Expression Library;F Box Domain;Family;FBXO2 gene;Flow Cytometry;Glycopeptides;Glycoproteins;glycoproteomics;glycosylation;Immunohistochemistry;improved;Infection;instrumentation;Lectin;Legal patent;Link;Malignant Neoplasms;manufacturing scale-up;Maps;Mass Spectrum Analysis;Mus;Mutate;Nature;Neurodegenerative Disorders;novel;Peptides;Performance;Phase;Plant Lectins;Plant Resins;Play;Polysaccharides;Positioning Attribute;preference;Procedures;Production;Property;Protein Family;Protein Subunits;Proteins;Protocols documentation;Reagent;Recombinants;Research;Role;Sampling;scale up;screening;Serum;Site;Specificity;Structural Models;Structure;sugar;targeted biomarker;Techniques;Technology;tool;ubiquitin ligase;ubiquitin-protein ligase;Variant;Western Blotting;Yeasts

PROJECT_TITLE: Engineered Pan-Specific Reagents for N-Glycan Detection and Enrichment


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Pediatric;Rare Diseases

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: Project Narrative Chronic nonbacterial osteomyelitis (CNO) is a severe autoinflammatory bone disease that causes debilitating complications and poor quality of life. Assessments of disease activity, comparison of effectiveness of various durations of nonsteroidal anti-inflammatory drugs, selection of second-line treatments have been challenging due to rarity of CNO. Our proposed study will leverage our existing CHronic nonbacterial Osteomyelitis International Registry (CHOIR), validated clinical disease assessment score (CDAS) and secondary imaging outcome to address these knowledge gaps and provide evidence for improved clinical care.

PI_NAMEs: ZHAO, YONGDONG  (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Address;Adult;Affect;autoinflammatory;Awareness;bisphosphonate;bone;Bone Diseases;Child;Childhood;Chronic;chronic recurrent multifocal osteomyelitis;Clinical;clinical care;clinical decision-making;clinical phenotype;cohort;comparative effectiveness;Comparative Effectiveness Research;comparative effectiveness study;compare effectiveness;Data;Data Analyses;Data Collection;data registry;Databases;Deformity;design;Disease;Disease remission;Disease-Modifying Second-Line Drugs;disorder risk;effective therapy;Effectiveness;effectiveness evaluation;Enrollment;Flare;follow-up;Future;high risk;Image;improved;improved outcome;Incidence;indexing;individual patient;Infrastructure;inhibitor;International;Knowledge;Laboratories;Lesion;Magnetic Resonance Imaging;Measurement;Measures;Non-Steroidal Anti-Inflammatory Agents;Osteomyelitis;Outcome;Pain;patient response;Patient-Focused Outcomes;Patients;Pharmacotherapy;primary endpoint;primary outcome;Probability;prospective;Prospective Studies;Quality of life;radiological imaging;Registries;Research;response;Retrospective Studies;rheumatologist;Safety;secondary endpoint;secondary outcome;side effect;Site;skeletal;Spinal;Spinal Fractures;standard care;Standardization;Sum;Surveys;Survival Analysis;Symptoms;Time;TNF gene;Translational Research;treatment duration;treatment group;treatment planning;Validation;Visit;young adult

PROJECT_TITLE: Comparative effectiveness study of current treatments in children with Chronic Nonbacterial Osteomyelitis (CNO)

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


ADMINISTERING_IC: EY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Prevention;Primary Health Care;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: MADISON

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Teleophthalmology using retinal cameras in primary care clinics has been shown to improve diabetic eye screening rates and visual outcomes, but remains greatly underutilized in the U.S. This multi-center randomized controlled trial proposes to test the effectiveness and generalizability of a promising implementation program (I- SITE: Implementation to Sustain Impact in Teleophthalmology) for sustaining increased diabetic eye screening rates using teleophthalmology in rural health systems. This research seeks to identify methods for successful integration of telemedicine technology into rural primary care workflows to prevent blindness from diabetes, the leading cause of blindness among working-age U.S. adults.

PI_NAMEs: LIU, YAO  (contact)

PROGRAM_OFFICER_NAME: LE, JIMMY TOAN

PROJECT_TERMS: acceptability and feasibility;Acute;Address;Adherence;Adult;Affect;Age;American;Area;Blindness;care providers;Caring;clinical practice;Clinical Trials;Cluster randomized trial;Communities;Data;design;Diabetes Mellitus;diabetic;Diabetic Retinopathy;Early Diagnosis;Early treatment;Effectiveness;effectiveness evaluation;effectiveness testing;Elements;evidence base;Eye;Face;Future;Goals;Guidelines;Health Services Accessibility;Health system;Health Technology;Healthcare Systems;Human Resources;implementation cost;implementation evaluation;implementation measures;improved;insight;Insurance Coverage;Interview;K-Series Research Career Programs;Knowledge;Measures;meetings;Mentored Patient-Oriented Research Career Development Award;Methods;National Eye Institute;Outcome;Outcome Measure;Patients;pilot test;Prevalence;prevent;Primary Care;primary care clinic;primary care provider;Primary Health Care;primary outcome;programs;Public Health;Randomized, Controlled Trials;Recording of previous events;Research;Retina;Retinal Diseases;Risk;Risk Reduction;Rural;rural Americans;Rural Community;Rural Health;rural patients;Rural Population;scale up;screening;Screening Result;secondary outcome;Strategic Planning;Structure;Technology;telehealth;Telemedicine;teleophthalmology;Testing;Time;Translating;Translations;Travel;treatment as usual;United States National Institutes of Health;Urban Population;urban underserved;Vision;Visual;Visual impairment;Work

PROJECT_TITLE: I-TRUST: Implementation of Teleophthalmology in Rural Health Systems Study


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Clinical Research;Pediatric

ORG_CITY: ROCKVILLE

ORG_NAME: WESTAT, INC.

ORG_STATE: MD

PI_NAMEs: CHAPMAN, KATHY  (contact)

PROJECT_TERMS: Adult;Attention;Biometry;Blood;Blood donor;Blood Transfusion;Brazil;Caring;central database;Charge;Child;Childhood;Collaborations;Community Hospitals;Contractor;Contracts;Data;Data Analyses;Data Collection;Data Coordinating Center;data management;Data Set;Databases;Development;Documentation;Effectiveness;Ensure;Epidemiology;epidemiology study;Ethical Review;Evaluation Studies;expiration;Funding;Group Meetings;Hospitals;Human;human subject protection;improved;Institutional Review Boards;International;Laboratory Study;Link;Logistics;Manuals;medical specialties;member;National Heart, Lung, and Blood Institute;neonate;operation;Pediatric Research;Phase;Preparation;Privatization;Procedures;programs;protocol development;Protocols documentation;Publications;Records;Reporting;Research;Research Activity;Research Personnel;research study;Resources;Retrieval;Safety;Services;Site Visit;Statistical Data Interpretation;success;System;technical report;Training;Transfusion;Travel;Vascular blood supply;Veins;web site;working group

PROJECT_TITLE: REDS-IV-P DATA COORDINATING CENTER (DCC) PHASE 3


NIH_SPENDING_CATS: Cancer;Immunotherapy;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PI_NAMEs: TANSEY, WESLEY  (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Attention;Bioinformatics;Biological;cancer immunotherapy;cancer therapy;Cell Communication;Cities;Clinical;college;Communities;Computational Biology;Data;Development;Education and Outreach;Educational Activities;Educational workshop;Epithelioid Sarcomas;Faculty;Fostering;Graduate Education;graduate student;high school;Imagination;immune checkpoint blockade;Immune system;Immunologics;Immunologist;Immunology;International;Knowledge;Malignant Neoplasms;Mathematics;Memorial Sloan-Kettering Cancer Center;Methods;Modeling;New York;next generation;outreach;programs;Research;Role;Scientist;skills;SMARCB1 gene;STEM student;success;symposium;System;Systems Biology;Training;treatment response;tumor;tumor progression;tumor-immune system interactions;Tumor-infiltrating immune cells;undergraduate education;undergraduate student

PROJECT_TITLE: Outreach Core


NIH_SPENDING_CATS: Cancer;Uterine Cancer;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PI_NAMEs: LLOYD, SCOTT  (contact)

PROGRAM_OFFICER_NAME: PTAK, KRZYSZTOF

PROJECT_TERMS: Annual Reports;anti-cancer research;Applications Grants;Award;Awareness;Basic Science;beneficiary;Budgets;Cancer Center;Cancer Center Support Grant;cancer clinical trial;career;Catchment Area;Characteristics;Clinical;Clinical Research;Clinical Trials;combat;Communication;Comprehensive Cancer Center;computer infrastructure;computer network;Computer software;cost effective;Database Management Systems;Databases;Dedications;Development;Documentation;Education;Employee;Environment;Equipment;Evaluation;experience;Faculty;Faculty Recruitment;faculty support;flexibility;Funding;Goals;Grant;Head;Human Resources;improved;informatics shared resource;innovation;Journals;Leadership;Maintenance;Malignant Neoplasms;Marketing;Medicine;meetings;member;Mission;Monitor;National Cancer Institute;Office of Administrative Management;operation;Outcome;outreach;Patients;Pilot Projects;Policies;Population Research;Population Sciences;Positioning Attribute;Process;programs;recruit;Research;research and development;Research Institute;Research Personnel;Resource Sharing;Resources;Science;Security;Serous;service delivery;Services;software systems;Strategic Planning;Strategic vision;success;symposium;System;Telephone;trial planning;tumor microenvironment;Universities;Utah;Uterine Cancer;Work

PROJECT_TITLE: Cancer Center Administration


PROJECT_TERMS: Annual Reports;anti-cancer research;Applications Grants;Award;Awareness;Basic Science;beneficiary;Budgets;Cancer Center;Cancer Center Support Grant;cancer clinical trial;career;Catchment Area;Characteristics;Clinical;Clinical Research;Clinical Trials;combat;Communication;Comprehensive Cancer Center;computer infrastructure;computer network;Computer software;cost effective;Database Management Systems;Databases;Dedications;Development;Documentation;Education;Employee;Environment;Equipment;experience;Faculty;Faculty Recruitment;faculty support;flexibility;Funding;Goals;Grant;Head;Human Resources;improved;informatics shared resource;innovation;Journals;Leadership;Maintenance;Malignant Neoplasms;Marketing;Medicine;meetings;member;Mission;Monitor;National Cancer Institute;Office of Administrative Management;operation;Outcome;outreach;Patients;Pilot Projects;Policies;Population Research;Population Sciences;Positioning Attribute;Process;programs;recruit;Research;research and development;Research Institute;Research Personnel;Resource Sharing;Resources;Science;Security;service delivery;Services;software systems;Strategic Planning;Strategic vision;success;symposium;System;Telephone;transcriptomics;trial planning;tumor heterogeneity;Underrepresented Populations;Universities;Utah;Work


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Precision Medicine;Prevention;Radiation Oncology

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PI_NAMEs: JI, HANLEE P (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: 3-Dimensional;Address;Advanced Malignant Neoplasm;Anti-CD47;biobank;Biological;Biological Models;Brain;brain cell;Brain Neoplasms;cancer genome;cancer type;cell type;Cells;Cellular Tropism;Characteristics;Clinical;Computer Models;Data;Data Set;differential expression;Disease Progression;Early Diagnosis;Foundations;functional status;Genes;genomic biomarker;genomic data;Genomic Instability;genomic predictors;genomic signature;Genomics;Goals;Growth;high risk;imaging modality;Immune;Immunologic Surveillance;in vitro testing;Incidence;insight;Interruption;Link;Macrophage;Magnetic Resonance Imaging;Maintenance;Malignant neoplasm of brain;Malignant Neoplasms;Metastatic malignant neoplasm to brain;Metastatic Neoplasm to the Central Nervous System;Microglia;Modeling;Molecular;Morbidity - disease rate;mortality;multiple omics;Mutation;Neoplasm Metastasis;Neuroimmune;Neurologic;neuropathology;Operative Surgical Procedures;Organoids;Outcome;Pathway interactions;Patients;Peripheral;Play;Prediction of Response to Therapy;predictive marker;predictive modeling;pressure;Primary Neoplasm;Prognostic Marker;programs;Radiation;Radiation therapy;Radiation Tolerance;radioresistant;Recording of previous events;Resected;Resources;response;Risk;Role;Sampling;screening;Selection for Treatments;single cell genomics;standard of care;Statistical Models;Testing;translational study;Treatment Efficacy;Treatment outcome;treatment response;Tropism;tumor;tumor microenvironment;tumor-immune system interactions

PROJECT_TITLE: Determine the mechanisms of acquired brain-tropism


NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Cancer;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PROJECT_TERMS: Alaska Native;American Indians;Annual Reports;anti-cancer research;Applications Grants;Award;Awareness;Basic Science;beneficiary;Budgets;Cancer Center;Cancer Center Support Grant;cancer clinical trial;career;Catchment Area;Characteristics;Clinical;Clinical Research;Clinical Trials;combat;Communication;Comprehensive Cancer Center;computer infrastructure;computer network;Computer software;cost effective;Database Management Systems;Databases;Dedications;Development;Documentation;Education;Employee;Environment;Equipment;experience;Faculty;Faculty Recruitment;faculty support;flexibility;Funding;Goals;Grant;Head;Human Resources;improved;informatics shared resource;innovation;Journals;Leadership;Maintenance;Malignant Neoplasms;Marketing;Medicine;meetings;member;Mission;Monitor;National Cancer Institute;Office of Administrative Management;operation;Outcome;outreach;Patients;Pilot Projects;Policies;Population Research;Population Sciences;Positioning Attribute;Process;programs;recruit;Research;research and development;Research Institute;Research Personnel;Resource Sharing;Resources;Science;Security;service delivery;Services;software systems;Strategic Planning;Strategic vision;success;symposium;System;Telephone;trial planning;Universities;Utah;Work


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Clinical Research;Physical Rehabilitation;Rehabilitation

PHR: PROJECT NARRATIVE Reverse total shoulder arthroplasty is a joint replacement of non-anatomic design that relieves pain and restores arm elevation, but many patients lose arm rotational range of motion or experience functional deficits. Patient- specific humeral anatomy is not currently considered during the procedure but offers opportunities to optimize shoulder function by improving muscle efficacy through its relationship to humeral implant placement. This research challenges the standard of care in reverse shoulder arthroplasty, thereby influencing pre-operative planning, implant designs, the procedure, and rehabilitation, with the objective to restore shoulder function and set realistic and reliable expectations for the surgery.

PI_NAMEs: HENNINGER, HEATH BYRON (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: 3-Dimensional;Activities of Daily Living;Affect;Algorithms;Anatomy;Anterior;arm;Articular Range of Motion;Articulation;biomechanical test;Biomechanics;Cadaver;Clinic;Clinical;Clinical assessments;Clinical Data;clinical imaging;cohort;Computer Models;Consensus;Data;Data Collection;deltoid muscle;design;Elbow;expectation;experience;Experimental Models;experimental study;follow-up;Forearm;Functional disorder;General Population;Head;Image;Implant;implant design;Implantation procedure;improved;improved outcome;in vivo;Joints;kinematics;Knowledge;Laboratories;Length;Link;Measures;Modeling;Modification;Motion;Muscle;Operative Surgical Procedures;Outcome;Outcome Measure;Pain;pain relief;Passive Range of Motion function;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Postoperative Period;Procedures;Quality of life;Reaction;recruit;rehabilitation strategy;Rehabilitation therapy;Replacement Arthroplasty;Research;response;Rest;Rotation;Rotator Cuff;Shoulder;standard of care;stereoradiography;Surgeon;System;Testing;Three-Dimensional Imaging;tool;Torsion;Ultrasonography;ultrasound;Variant;Work;X-Ray Computed Tomography

PROJECT_TITLE: Biomechanics of Reverse Total Shoulder Arthroplasty

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Hair follicle stem cells (HFSCs) are multipotent epithelial stem cells that fuel the production of hair follicles throughout the life of an organism. We have recently identified that the key chromatin regulator, the Polycomb complex, not only plays a critical role in HFSCs but also exerts its function via a novel mechanism of gene regulation. By dissecting the molecular mechanisms of Polycomb-mediated regulation of HFSCs, we aim to gain insight into the regulation of HFSC during normal homeostasis as well as uncover processes that go awry in human diseases such as cancer.

PI_NAMEs: EZHKOVA, ELENA  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Ablation;Acceleration;Adult;Aging;Animals;Biochemical;Biological Process;bone morphogenetic protein receptors;ChIP-seq;Chromatin;comparison control;Complex;Cues;Data;daughter cell;derepression;Disease;Down-Regulation;epithelial stem cell;Equilibrium;Experimental Genetics;experimental study;Gene Activation;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic Transcription;Growth;Hair;Hair follicle structure;Homeostasis;Human;human disease;in vivo;inhibitor;insight;Knockout Mice;Lead;Life;loss of function;Malignant Neoplasms;Mediating;Molecular;multipotent cell;Multipotent Stem Cells;Mus;Mutate;Natural regeneration;novel;Organism;Phenotype;Play;Polycomb;PRC1 Protein;premature;Process;Production;Proliferating;Regulation;Reporting;Repression;Rest;Role;Signal Transduction;Skin;Skin Cancer;skin disorder;stem cells;System;Testing;Transcription Coactivator;transcriptome sequencing;WNT Signaling Pathway

PROJECT_TITLE: Toward Understanding the Role of the Polycomb Complex in Skin Control


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Precision Medicine;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: The introduction of clinical exome sequencing and whole genome sequencing has transformed our ability to diagnose patients with suspected genetic disease. However, up to 70% of patients with suspected genetic disease remain undiagnosed likely because their disease-causing variant(s) has yet to be discovered or the clinical significance of variants identified in genomic studies remains unclear. The BCM Center for Precision Medicine Modeling will support local, national, and international programs and individual researchers in the development of precision animal models that end the diagnostic odyssey of patients with undiagnosed, rare, and Mendelian diseases and serve as resources for pre-clinical studies investigating personalized medicine approaches to their care.

PI_NAMEs: BURRAGE, LINDSAY C;HEANEY, JASON D. (contact);MILOSAVLJEVIC, ALEKSANDAR

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Affect;Animal Model;Back;Bioinformatics;Body System;Caring;Clinical;clinical care;clinical diagnostics;Clinical Research;Clinical Trials;clinically significant;Collaborations;college;Communities;Databases;design;Development;Diagnosis;Diagnostic;Disease;disease model;disease-causing mutation;DNA lesion;Drosophila melanogaster;exome sequencing;fly;gene discovery;Genes;Genetic Diseases;genetic disorder diagnosis;Genome;genome sequencing;Genomics;Goals;House mice;Human Genetics;Human Genome;Individual;Infrastructure;International;Leadership;Medical Genetics;Medicine;Mendelian disorder;metabolomics;model organism;Modeling;Modification;Molecular;Molecular Genetics;multidisciplinary;Mus;nonhuman primate;Patient Care;Patients;personalized approach;personalized medicine;Phenotype;precision medicine;preclinical study;Production;programs;Provider;Rare Diseases;recruit;Reporting;Research Personnel;Resources;Structure;Study models;Techniques;Technology;therapeutic evaluation;tool;transcriptome sequencing;Translating;translational impact;translational study;Translations;Variant;variant of unknown significance;Vision;whole genome

PROJECT_TITLE: BCM Center for Precision Medicine Models


ADMINISTERING_IC: AI

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE: Overall The Harvard University CFAR (HU CFAR) provides the infrastructure to coordinate, support and add value to Harvard investigators’ cutting-edge multidisciplinary HIV research programs and to forge new collaborations and synergies. The HU CFAR pursues innovative initiatives to address critical HIV-related research priorities and train the next generation of HIV researchers. By leveraging the exceptional strengths of Harvard and its institutional support, the HU CFAR promises to continue to provide major leadership in the global effort to prevent and treat HIV.

PI_NAMEs: GANDHI, RAJESH T (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Area;Award;base;Basic Science;Behavioral Sciences;biobehavior;Bioinformatics;Biometry;Boston;career;catalyst;Clinical;Clinical Sciences;co-infection;Collaborations;community collaboration;community engaged research;community organizations;community partners;community science;comorbidity;Dana-Farber Cancer Institute;Development;Disease;Ensure;Epidemic;equity, diversity, and inclusion;forging;Funding;General Hospitals;Generations;Goals;Grant;Health;HIV;HIV therapy;Hospitals;improved;Incidence;Infection;Infrastructure;innovation;Institution;Interdisciplinary Study;International;Investments;Israel;laboratory equipment;Leadership;Malignant Neoplasms;Massachusetts;Medical center;medical schools;Medicine;member;Mentors;Mentorship;Mission;multidisciplinary;next generation;Pediatric Hospitals;Persons;Pilot Projects;Play;Population;prevent;Prevention;Process;programs;Public Health;Public Health Schools;Recommendation;recruit;Research;Research Personnel;Research Priority;Research Training;Role;Schools;Services;Site;Strategic Planning;Sum;synergism;Translational Research;United States National Institutes of Health;Universities;Woman;working group

PROJECT_TITLE: Harvard University Center for AIDS Research


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Infectious Diseases;Prevention

PI_NAMEs: TSIBRIS, ATHE M. (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Applications Grants;Area;Award;Basic Science;biobehavior;career;career development;clinical epidemiology;Collaborations;Communities;community science;Computational Biology;Development;Disease;Education;Educational workshop;Ensure;equity, diversity, and inclusion;Evolution;Faculty;Feedback;flexibility;Fostering;Foundations;Funding;Funding Mechanisms;Funding Opportunities;Generations;Goals;Grant;health economics;HIV;HIV/AIDS;Hospitals;Incentives;Individual;Institution;International;Investments;leadership development;medical schools;Medicine;meetings;member;Mentors;Mentorship;microbial genomics;Mission;Modeling;Mollies;multidisciplinary;next generation;Outcome;outreach;Pathogenesis;Process;Program Reviews;programs;Public Health Schools;Publications;Request for Proposals;Research;Research Activity;Research Personnel;Research Priority;Resources;Science;Scientist;Site;skills;South Africa;Strategic Planning;Structure;Technology;Training;training opportunity;Translational Research;Uganda;Underrepresented Minority;United States National Institutes of Health;Universities;Virginia;Woman;working group;Writing

PROJECT_TITLE: Developmental and Mentoring Core


NIH_SPENDING_CATS: Aging;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Although there are significant sex differences in the expression and onset of major medical and psychiatric disorders, clinical decisions based on research are still based primarily on data from men and may often be inappropriate for women. Thus, there remains a strong need for the Harvard BIRCWH program to educate, train, and develop junior investigators who will commit their careers to studying the impact of sex and gender on clinical disorders. Our Harvard BIRCWH program will provide the basis for the development of sex- dependent treatment approaches and public awareness of the importance of these sex-dependent health issues for families and society.

PI_NAMEs: GOLDSTEIN, JILL M (contact);REXRODE, KATHRYN M

PROGRAM_OFFICER_NAME: TIGNO, XENIA

PROJECT_TERMS: Adult;Aging;Autoimmune Diseases;Basic Science;bench to bedside;Boston;Cardiovascular Diseases;career;Career Mobility;child bearing;Clinical;Clinical Research;Dana-Farber Cancer Institute;Development;Disease;disorder risk;Disparity;Endocrine;Etiology;Exposure disparity;Faculty;Female;Fetal Development;Genes;Health;health difference;health disparity;Home;Hormones;Hospitals;Incidence;innovation;Institution;Interdisciplinary Study;interest;Israel;life span;Malignant Neoplasms;Medical center;medical schools;Medicine;men;Menopause;Mentors;Mission;Modeling;neuropsychiatric disorder;Neurosecretory Systems;next generation;Pediatric Hospitals;Process;programs;Puberty;Public Health Schools;Recording of previous events;reproductive;Resources;Role;Scientist;sex;Sex Differences;Sexual Dysfunction;Site;socioenvironmental factor;Structure;Thinking;Training;Training Programs;translational approach;Treatment Efficacy;Woman;Women's Health;Work

PROJECT_TITLE: Hormones and Genes in Women's Health: From Bench to Bedside


NIH_SPENDING_CATS: Arthritis;Genetics;Osteoarthritis;Pain Research;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: The study of patients with rare diseases may provide insights that benefit patients with common diseases. To complement our iPSC-based model, we generated a large animal model of the rare human disease Progressive Pseudorheumatoid Arthropathy of Childhood (PPAC) in order to understand its pathobiology. Knowledge gained from our studies will be relevant and applicable to patients with PPAC and could benefit patients with common degenerative joint diseases, such as osteoarthritis.

PI_NAMEs: CRAFT, APRIL MARIE (contact);SUVA, LARRY J.;WARMAN, MATTHEW L

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Affect;Age;Age Months;Animal Model;Animals;Ankle;Arthralgia;arthropathies;articular cartilage;autosome;Biochemical;Biochemistry;Biological;Biological Process;biomechanical test;Biomechanics;Biopsy;Birth;Blinded;bone imaging;boys;Cartilage;Cartilage Diseases;Cell Line;Child;Childhood;Chondrocytes;Clinical;clinical examination;Complement;Cultured Cells;Data;Degenerative polyarthritis;Disease;Disease Progression;effectiveness evaluation;egg;Ethics;Exhibits;experimental study;Failure;Female;Fertilization in Vitro;Functional disorder;Gait;Genes;Genetic;Genetic Transcription;Genotype;girls;Goals;Hip region structure;hip replacement arthroplasty;Histologic;Histology;Homeostasis;Human;human disease;human pluripotent stem cell;improved;In Vitro;in vitro Model;in vivo;in vivo evaluation;in vivo Model;induced pluripotent stem cell;insight;Joints;Knee;knee replacement arthroplasty;Knock-out;Knockout Mice;Knowledge;loss of function mutation;male;mitochondrial metabolism;Movement;Mus;Mutation;Newborn Infant;novel strategies;novel therapeutics;offspring;Other Genetics;Pain;Palpation;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Phenotype;Positioning Attribute;Pre-Clinical Model;prevent;Process;Production;Progressive Disease;prospective;Proteins;radiological imaging;Raman Spectrum Analysis;Rare Diseases;recessive genetic trait;Replacement Arthroplasty;Reproducibility;response;Role;sex;Sheep;Shoulder;Signal Pathway;Signal Transduction;skeletal disorder;Specimen;sperm cell;Statistical Data Interpretation;stem cell model;Teenagers;Testing;therapy development;Time;Tissue Differentiation;Tissue Model;Tissues;transcriptome sequencing;transcriptomics;unethical;Use Effectiveness;WISP3 gene;young adult

PROJECT_TITLE: WISP3 and Progressive Pseudorheumatoid Arthropathy of Childhood


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases

ORG_CITY: STONY BROOK

ORG_DEPT: PATHOLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: PROJECT NARRATIVE Pancreatic cancer is an aggressive disease with limited treatment options. We find that Gα13, a signaling mediator of G protein coupled receptors (GPCRs) which are major target of approved drugs, regulates mTORC1- mediated tumor metabolism and inflammation. In this proposal we will determine whether Gα13 status determine the susceptibility to perturbations of metabolism and inflammatory mediators.

PI_NAMEs: SHIELDS, MARIO  (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Acceleration;Anti-Inflammatory Agents;Antibodies;Biological Assay;Biological Process;Cancer Biology;cancer cell;cancer type;Cell Death Induction;Cell Physiology;Cell Surface Proteins;Cells;cytokine;Data;Development;Disease;drug development;Exhibits;Family;FRAP1 gene;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Gene Expression Profiling;Genes;Genetic;Genetic Engineering;genetic signature;GTP-Binding Proteins;Heterotrimeric GTP-Binding Proteins;Human;Immune;immune cell infiltrate;In Vitro;in vivo;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;innovation;insight;interest;Invaded;KRAS oncogenesis;Lymphoma;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Mediator;member;Metabolism;Mitochondria;mitochondrial metabolism;Modeling;mouse model;mRNA Expression;mTOR Inhibitor;Mus;mutant;Mutation;Myelogenous;Myeloid-derived suppressor cells;neoplastic cell;Outcome;Pancreas;pancreatic cancer cells;pancreatic cancer model;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic neoplasm;Pancreatitis;patient stratification;Patients;Pharmaceutical Preparations;Predisposition;Process;Proteins;Publishing;pyrimidine metabolism;recruit;Regulation;Reporting;Research;response;RNA Interference;Role;Signal Transduction;Sirolimus;Slice;Specimen;survival outcome;Testing;therapeutic target;therapy design;TP53 gene;tumor;tumor growth;tumor metabolism;tumor progression;Tumor Promoters;Tumor Promotion;Tumor Suppression;Tumor Suppressor Proteins;Tumor-Derived

PROJECT_TITLE: Elucidating the mechanism of Ga13 mediated tumor suppression in pancreatic cancer


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative The proposed research is aimed at understanding why some patients develop high blood pressure in the lungs (pulmonary arterial hypertension, PAH). PAH is a serious and progressive disease with no cure and with 5-year mortality as great as 50%. In particular, we are trying to understand how the loss of capillaries and narrowing of arteries vessels happen and why they cause PAH development, and develop a new effective therapeutic strategy for the treatment of this devastating disease.

PI_NAMEs: DAI, ZHIYU  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Architecture;Arteries;Attenuated;Blood capillaries;Blood Vessels;Capillary Endothelial Cell;Cessation of life;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Data;Development;Disease;effective therapy;Endothelial Cells;endothelial dysfunction;Endothelium;Exhibits;Expectancy;Failure;Gases;Genes;Genetic;Glycolysis;Goals;Guide RNA;Heart Hypertrophy;Homeostasis;Human;Hypertension;induced pluripotent stem cell;knock-down;Knockout Mice;Lesion;Lung;Mediating;Mediator;Mesenchymal;Modeling;Molecular;mortality;mouse model;Mus;nanoparticle;new therapeutic target;notch protein;novel;novel marker;novel therapeutic intervention;Nutrient;Organ;Oxygen;Pathogenesis;Patients;pharmacologic;Phenotype;Population;premature;preservation;primary pulmonary hypertension;programs;Progressive Disease;Proliferating;pulmonary arterial hypertension;pulmonary vascular disorder;pulmonary vascular remodeling;Pulmonary Vascular Resistance;repaired;Reporter;Research;right ventricular failure;Rodent;Role;Signal Transduction;single-cell RNA sequencing;SOX17 gene;Specific qualifier value;stem cells;Stromal Cell-Derived Factor 1;therapeutically effective;Thinness;Tissues;treatment strategy;Up-Regulation;Venous;VWF gene

PROJECT_TITLE: General Capillary to Arterial Endothelial Cell Transition in Pulmonary ArterialHypertension

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RCCS-Q(03)]


ACTIVITY: ZIC

FUNDING_MECHANISM: INTRAMURAL RESEARCH

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Genetics;Immunotherapy;Rare Diseases

ORG_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

PI_NAMEs: GADINA, MASSIMO  (contact)

PROJECT_TERMS: Acne;Acute suppurative arthritis due to bacteria;Affect;Alleles;antagonist;Autoimmune;Autoimmune biomarker;Autoimmune Diseases;autoinflammatory diseases;Basic Science;Binding;Biological Assay;biomarker discovery;C-reactive protein;Cellular biology;Classification;Clinical;clinical application;Clinical Investigator;Clinical Trials;cohort;Collaborations;cytokine;Cytokine Signaling;Cytotoxic T-Lymphocytes;Development;Disease;Disintegrins;Feedback;Generations;Genetic Polymorphism;genetic risk factor;genetic variant;Genotype;gut inflammation;Haplotypes;HLA Antigens;Immunoassay;Immunologics;Immunology procedure;Immunophenotyping;Impairment;Individual;Inflammatory;inhibitor;Instruction;Insulin-Dependent Diabetes Mellitus;Interferon Type II;Interleukin 6 Receptor;Interleukin-6;Italy;knockout gene;Laboratory Research;Life;Lung Diseases;Lymphoid Cell;Manuscripts;Measures;Mediating;Membrane;Metalloproteases;Methods;Minor;molecular marker;Mus;Musculoskeletal;National Human Genome Research Institute;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Natural Killer Cells;novel strategies;PAPA syndrome;Paper;Pathology;Patients;Peripheral Blood Mononuclear Cell;pharmacologic;Phenotype;Play;Population;Production;Publishing;Pyoderma Gangrenosum;Regulatory T-Lymphocyte;Research;Research Personnel;response;Rheumatism;Rheumatoid Arthritis;Role;Rome;Serum;Services;Signal Transduction;Skin;Source;STAT4 protein;Syndrome;T-Lymphocyte;Temporal Arteritis;tenure track;tocilizumab;translational goal;translational immunology;Translational Research;United States National Academy of Sciences;Universities;Work

PROJECT_TITLE: Translational Immunology research: a support for clinical immunological research


ACTIVITY: ZID

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Hematology;Immunization;Infectious Diseases;Pediatric;Prevention;Primary Immunodeficiencies;Rare Diseases;Vaccine Related;Vaccine Related - AIDS;Vector-Borne Diseases

ORG_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

PI_NAMEs: SPISSO, SUZANNE  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;Antibodies;Area;Aspirin;Atopic Dermatitis;Blood;Chronic Granulomatous Disease;Clinical;clinical center;Clinical Management;Clinical Research;clinical training;Clinical Trials;Coagulation Process;Coccidioidomycosis;Common Variable Immunodeficiency;congenital immunodeficiency;Continuing Education;COVID-19;Cryptococcosis;Cysticercosis;Deficiency Diseases;Development;Disseminated eosinophilic collagen disease;Ebola;Eligibility Determination;Eosinophilia;Fellowship;GATA2 deficiency;Genetic Markers;HIV;Hyper-IgE Syndrome;IgE;Immune;immune function;immune reconstitution;Immune system;immunodeficiency;Immunologic Deficiency Syndromes;Infection;Inflammatory;Influenza;Informatics;Intramural Research;Intramural Research Program;Laboratories;Leukocyte Adhesion Deficiency;liver injury;Lyme Disease;Lymphopenia;Malaria;Medical Students;Mission;Mycobacterium Infections;Mycoses;National Institute of Allergy and Infectious Disease;next generation;non-tuberculous mycobacterial infection;Occupations;operation;Operations Research;Patient Care;patient safety;Persons;Policies;Predisposition;programs;recruit;Refractory;Regulation;Research;Research Personnel;Resolution;Resources;Respiratory syncytial virus;Science;screening;Services;student training;Syndrome;System;Tissues;Training;Training Programs;Tuberculosis;United States National Institutes of Health;Virus Replication;volunteer

PROJECT_TITLE: ICMOB - Clinical Support Services


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: SALIBA, KATHRYN  (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;Acquired Immunodeficiency Syndrome;antibody test;Antigens;assay development;Back;bench-to-bedside translation;biobank;bioinformatics pipeline;Biological Assay;Biological Markers;Biopsy;Budgets;Cell Line;Cell Proliferation;Cell Separation;CLIA certified;Clinical;Clinical Research;Clinical Trials;Collaborations;Consensus Sequence;Contracts;COVID-19 assay;COVID-19 intervention;COVID-19 therapeutics;Development;Disease;Ebola;Emergency response;Emergency Situation;Emerging Communicable Diseases;Ensure;Enzyme-Linked Immunosorbent Assay;Flow Cytometry;Genomics;Government;Hemagglutination;Hepatitis C virus;HIV;Human Herpesvirus 4;immune function;Immunologic Monitoring;Immunoprecipitation;Influenza;International Network for Strategic Initiatives in Global HIV Trials;Laboratories;Lead;Luciferases;magnetic beads;Maintenance;member;Mission;Monitor;National Cancer Institute;National Institute of Allergy and Infectious Disease;neutrophil;novel;Peripheral Blood Mononuclear Cell;Plasma;programs;Prospective Studies;Public Health;repository;Research;Research Personnel;Research Project Grants;respiratory;Respiratory Tract Infections;Retrospective Studies;Running;Sampling;Scientist;Serology;Serum;Services;Specimen;Swab;System;Technology;Therapeutic;translational medicine;Vaccine Research;Vaccines;Viral;Viral Load result;Virus;Work;ZIKA

PROJECT_TITLE: Laboratory Support Services


ACTIVITY: ZIJ

NIH_SPENDING_CATS: American Indian or Alaska Native;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PI_NAMEs: HAUSERMAN, JANELLE  (contact)

PROJECT_TERMS: American Indians;Area;Award;Awareness;Baltimore;Basic Science;career;Career Choice;career development;Career Exploration;Clinic;Clinical;Clinical Research;Clinical Trials;Collaborations;college;Communication;Communities;Community Health;County;Data Collection;design;Development;Development Plans;Educational Curriculum;Electronic Mail;Engineering;Equipment;Ethics;Evaluation;Event;Extramural Activities;Faculty;General Population;graduate school preparation;Grant;Hispanic Americans;improved;interest;Internet;Intramural Research;Intramural Research Program;Journals;Laboratories;Leadership;Logistics;Maintenance;Maryland;Medical Research;medical schools;Medical Students;meetings;Mentors;Mexican Americans;minority student;Modeling;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Native Americans;Nurse Practitioners;operation;outreach;Pamphlets;Parents;Patients;Persons;Play;Population;Postbaccalaureate;Postdoctoral Fellow;posters;pre-doctoral;Printing;Production;programs;Publications;recruit;Research;Resources;responsible research conduct;Rheumatology;Role;Safety;Scholars Program;Science;Scientific Advances and Accomplishments;Services;Site;skills;skills training;Societies;Spanish/English;summer internship;symposium;tool;Training;Training and Education;Training Programs;Training Support;Translational Research;transmission process;United States National Institutes of Health;Universities;Update;usability;virtual;Visit;volunteer;Washington;web site;Work;working group;Writing

PROJECT_TITLE: Office for Scientific Operations


NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: PROJECT NARRATIVE Tough fibrous interfaces between tissues are a common location of injury and source of pathology, pain and disability. Surgical repairs of interfaces that are desirable proceed in the absence of knowledge of the mechanisms that endow fibrous interfaces with toughness, and unsurprisingly have very high failure rates of up to a nearly unbelievable 94%. By developing and testing the first mathematical models for the toughness of this class of interfaces, we hope to identify the mechanisms of toughening definitively, and more broadly to provide technology that enables design of improved surgical procedures.

PI_NAMEs: GENIN, GUY M (contact);THOMOPOULOS, STAVROS

PROJECT_TERMS: absorption;Adhesions;Adhesives;Animal Model;Automobile Driving;behavior prediction;Biological Models;bone;bone repair;Bone Tissue;Botulinum Toxin Type A;Brain;Characteristics;Collagen;Collagen Diseases;Collagen Fiber;Connective Tissue;cranium;crosslink;design;disability;Disease;Endowment;Environment;experimental study;Failure;Fiber;Foundations;Friction;Hernia;improved;In Vitro;in vivo;Injury;Intra-abdominal;Knowledge;Laparotomy;Length;Ligaments;Location;Machine Learning;mathematical model;mechanical behavior;Mechanics;Meniscus structure of joint;Mesentery;millimeter;Minerals;Modeling;Modification;molecular dynamics;multi-scale modeling;Mus;Musculoskeletal;nano;nanocrystal;nanoscale;Nature;Nervous System;older patient;Operative Surgical Procedures;Pain;Paralysed;Pathologic;Pathology;Patients;Peritoneal;Physiological;Pia Mater;Process;repaired;Rotator Cuff;Running;Skin;Slide;Source;Specimen;Stress;Structure;Surface;System;Technology;Tendinopathy;Tendon structure;Testing;Tissue Sample;Tissues;treadmill;Work

PROJECT_TITLE: Multiscale models of fibrous interface mechanics

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Services;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: FAIRFAX

ORG_NAME: ICF, INC., LLC

ORG_STATE: VA

PI_NAMEs: KENDRICK, BRANDON  (contact)

PROJECT_TERMS: Adoption;Awareness;behavioral health;Behavioral Research;Cancer Control;Communities;Community Health;Development;digital tool;Electronic Mail;Health behavior change;Health Services;Maintenance;mhealth interventions;National Cancer Institute;outreach;Population Group;programs;Public Health;Research;Resources;Services;smoking cessation;social media;Testing;usability;virtual;web site;webinar

PROJECT_TITLE: STAKEHOLDER ENGAGEMENT AND OUTREACH SUPPORT FOR HEALTH BEHAVIOR CHANGE AND CANCER CONTROL RESOURCES


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Comparative Effectiveness Research;Contraception/Reproduction;Patient Safety;Prevention;Women's Health Research

ORG_CITY: MORRISVILLE

ORG_NAME: HEALTH DECISIONS, INC.

ORG_STATE: NC

PI_NAMEs: DART, CLINT   (contact)

PROJECT_TERMS: Clinical;clinical development;Clinical Practice Guideline;Clinical Trials;Clinical Trials Network;Conduct Clinical Trials;Contraceptive Agents;Contraceptive methods;Development;Devices;drug candidate;Female Contraceptive Agents;Formulation;Goals;Good Clinical Practice;Gynecologic;Individual;Insurance;Investigation;Investigational New Drug Application;Male Contraceptive Agents;Marketing;men;Methods;Monitoring Clinical Trials;National Clinical Trials Network;National Institute of Child Health and Human Development;Notification;novel therapeutics;Pharmaceutical Preparations;Phase;product development;Protocols documentation;research and development;research clinical testing;Safety;Services;Site;stability testing;Statistical Data Interpretation;unintended pregnancy;Woman

PROJECT_TITLE: CORE FUNCTION ACTIVITIES - NICHD CCTN STATISTICAL AND CLINICAL COORDINATING CENTER


ADMINISTERING_IC: CK

IC_NAME: National Center for Emerging and Zoonotic Infectious Diseases

ORG_STATE: MO

PI_NAMEs: KWON, JENNIE H (contact)

PROJECT_TITLE: CK20-004, WASHINGTON UNIVERSITY & BJC EPICENTER TO PREVENT HEALTHCARE ASSOCIATED INFECTIONS & ANTIBIOTIC RESISTANCE


ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PI_NAMEs: LAUTENBACH, EBBING  (contact)

PROJECT_TITLE: Southeastern Pennsylvania Adult and Pediatric Prevention Epicenter Network


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Immunotherapy;Skin Cancer

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PI_NAMEs: KIRKWOOD, JOHN MUNN;ZAROUR, HASSANE M (contact)

PROGRAM_OFFICER_NAME: KUZMIN, IGOR A

PROJECT_TERMS: anti-PD-1;arm;B-cell receptor repertoire sequencing;Biological Assay;Catalogs;CD4 Positive T Lymphocytes;CD8B1 gene;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clinical;Clinical Trials;Computer Analysis;Flow Cytometry;Melanoma;microbial signature;Multiomic Data;Neoadjuvant Therapy;neoantigens;novel;Pathologic;Patients;pembrolizumab;Phase;predictive test;programmed cell death protein 1;programs;Proteins;proteomic signature;Proteomics;Resectable;Resistance;response;Skin Cancer;spectrograph;Squamous cell carcinoma;transcriptomics;tumor;tumor microenvironment

PROJECT_TITLE: Project 4: Neoadjuvant Clinical Trial with Pembrolizumab for Locally Advanaced Squamous Cell Carcinoma (SCC)


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: At-risk alcohol use, alcohol use disorder and return to drinking can have negative impacts on people with HIV (PWH). We propose to integrate alcohol reduction and relapse prevention interventions into HIV clinical care settings and to study the long-term effects of the spectrum of alcohol use on the alcohol and HIV care continua, comorbidities and disparities among a large, multi-site cohort of PWH.

PI_NAMEs: CHANDER, GEETANJALI ;MCCAUL, MARY E (contact)

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: Abstinence;Acquired Immunodeficiency Syndrome;Address;Age;alcohol abstinence;alcohol abuse therapy;Alcohol consumption;alcohol exposure;alcohol intervention;alcohol relapse;alcohol related problem;alcohol research;alcohol risk;alcohol screening;alcohol use disorder;Alcohols;analytical method;antiretroviral therapy;Attention;Behavioral;Biological Markers;Biometry;brief intervention;Cardiovascular Diseases;Caring;Chronic Disease;Classification;Clinic;Clinical;clinical care;clinical infrastructure;clinical research site;co-infection;Cognition;cohort;Collaborations;Communities;comorbidity;computerized;Computers;contextual factors;Continuity of Patient Care;Data;Database Management Systems;Development;Disease remission;Disparity;drinking;Drug usage;Effectiveness;effectiveness/implementation design;effectiveness/implementation trial;Electronic Health Record;Epidemic;Epidemiology;epidemiology study;evidence base;Evidence based intervention;frailty;Frequencies;Goals;Health;high risk drinking;HIV;Hybrids;implementation research;implementation science;implementation strategy;implementation/effectiveness;Individual;Intervention;Intervention Studies;Intervention Trial;Knowledge;Liver diseases;Long-Term Effects;Longitudinal Studies;Malignant Neoplasms;Measures;Medical Records;Mental disorders;Methods;Neighborhoods;novel;Outcome;Patient Outcomes Assessments;Patient Self-Report;Persons;pharmacologic;pilot trial;Prevalence;preventive intervention;Process;programs;Quality of life;Recording of previous events;Relapse;relapse prevention;Research;Research Infrastructure;Research Personnel;Research Priority;Research Project Grants;Resources;response;Risk;screening;Severity of illness;Site;social health determinants;Source;Structure;success;synergism;System;Testing;treatment as prevention;treatment strategy;United States Dept. of Health and Human Services;Universities;unsupervised learning;uptake;Viral hepatitis;Viremia

PROJECT_TITLE: Alcohol Research Consortium in HIV: Ending the HIV Epidemic through interventions and Epidemiology at the intersection of the alcohol and HIV care Continua


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;HIV/AIDS;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Cancer;Liver Disease;Prevention;Rare Diseases

PI_NAMEs: KIRK, GREGORY D (contact)

PROGRAM_OFFICER_NAME: DOMINGUEZ, GERALDINA

PROJECT_TERMS: Acceleration;Advocate;AFP gene;Africa;Africa South of the Sahara;African;Age;Albumins;Antigens;antiretroviral therapy;Attenuated;Behavioral;Biological Markers;Birth;Cancer Etiology;CD4 Lymphocyte Count;cell injury;Cessation of life;Chronic Hepatitis B;chronic infection;Cirrhosis;Clinical;Clinical Research;co-infection;cohort;Country;Data;data quality;design;Development;Diagnostic;Dose;dosimetry;elastography;Eligibility Determination;Etiology;Fibrosis;Foundations;Funding;Genotype;Goals;Guidelines;Hepatitis B e Antigens;Hepatitis B Infection;Hepatitis B Surface Antigens;Hepatitis B Vaccines;Hepatitis B Virus;Hepatitis C virus;high risk;high risk population;HIV;HIV Infections;Human;Image;Incidence;Individual;Infection;insight;Interruption;Interview;Investigation;Liver Fibrosis;Malignant Neoplasms;Medical;Mentors;Monitor;Mutation;novel;novel marker;Outcome;Oxidative Stress;Oxidative Stress Pathway;Participant;Pathogenesis;Pathology;Patients;Persons;Population;Population Attributable Risks;Population Research;Prevention;Preventive vaccine;Primary carcinoma of the liver cells;Process;Prospective cohort;Questionnaires;recruit;Research;Research Infrastructure;Research Personnel;Resources;response;Risk;Risk Factors;RNA;Sampling;Schistosoma mansonii infection;screening;Senegal;Serum;Serum Albumin;sociodemographics;Standardization;study population;Tenofovir;Testing;Translational Research;treatment as prevention;Treatment Protocols;treatment response;Uganda;ultrasound;Universities;vaccine acceptance;Viral;viral DNA;virus core;Virus Diseases;Virus Replication;Visit;α-Fetoproteins

PROJECT_TITLE: Antiviral treatment as prevention for HBV- and HBV/HIV-associated hepatocellular carcinoma