NIH_SPENDING_CATS: Bioengineering;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Neurosciences;Orphan Drug;Patient Safety;Precision Medicine;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Narrative: This project utilizes an implantable microdevice to measure multiple drug responses directly within the native tumor of glioblastoma cancer patients. We will determine whether these local microdose drug responses are predictive of systemic drug sensitivity for these patients, and will identify biomarkers of drug response that may be used to guide more effective therapy for patients in the future.

PI_NAMEs: JONAS, OLIVER  (contact);PERUZZI, PIER PAOLO

PROGRAM_OFFICER_NAME: SORG, BRIAN S

PROJECT_TERMS: Address;Adjuvant;Adjuvant Therapy;Adult;Adverse event;Affect;Apoptosis;Biological;Biological Markers;biomarker identification;Biopsy;Brain;Brain Neoplasms;brain tumor resection;Cancer Patient;cancer type;Cell Death;Cell Proliferation;Cells;chemotherapy;Chemotherapy and/or radiation;Clinical;clinical decision-making;Clinical Research;Clinical Treatment;Clinical Trials;cohort;Combined Modality Therapy;comparative;Data;Data Set;Development;Devices;Diffuse;Disease;DNA Damage;Dose;Drug Catalogs;Drug Combinations;Drug Delivery Systems;drug efficacy;Drug Exposure;drug response prediction;drug sensitivity;early detection biomarkers;effective therapy;Excision;Exposure to;functional status;Future;Genetic;Glioblastoma;Glioma;Goals;Head;Histologic;Immune;Immunologic Markers;Implant;implantation;improved;improved outcome;In Situ;in vivo;individual patient;interest;Intraoperative Complications;Knowledge;Length;Malignant - descriptor;Malignant neoplasm of brain;Mass Spectrum Analysis;Measurable;Measurement;Measures;Metabolic;metabolomics;Methylation;MGMT gene;microdevice;miniaturize;minimally invasive;Modeling;Molecular;multiple omics;Needle biopsy procedure;Newly Diagnosed;novel therapeutics;Oncogenic;Operative Surgical Procedures;optimal treatments;Outcome;Pathway interactions;patient response;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacodynamics;Pharmacotherapy;Phenotype;Physiological;Pilot Projects;precision drugs;precision medicine;predicting response;predictive marker;Predictive Value;Procedures;Process;Prognosis;Progression-Free Survivals;promoter;Proteomics;Regimen;Resected;Resistance;response;response biomarker;Retrieval;Safety;safety and feasibility;Schedule;Selection for Treatments;Severities;Signal Pathway;specific biomarkers;Specimen;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;standard of care;Stromal Cells;survival outcome;System;systemic toxicity;Techniques;Technology;temozolomide;Testing;tissue biomarkers;Tissues;tool;tool development;transcriptome;transcriptomics;Treatment Protocols;treatment response;treatment strategy;tumor;Tumor Markers;tumor microenvironment;Work

PROJECT_TITLE: Using implantable microdevices for deep phenotyping of multiple drug responses in brain tumor patients

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: MILWAUKEE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: SURGERY

ORG_FIPS: US

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE This application addresses a critical gap in the literature by providing critical foundational data to extend our knowledge of breast cancer (BC) risk among transgender (TG) individuals and begin to inform TG BC screening guidelines. This project will also extend the applicant’s knowledge, skills and experience supporting a successful career as a surgeon–scientist. Next steps include an R01 application to develop a multi-institutional longitudinal TG breast cancer screening program to definitively establish lifetime risk and incidence of BC development, provide evidence-based BC screening guidelines for TG persons, and address eliminating barriers to BC screening access and delivery for TG persons.

PI_NAMEs: CORTINA, CHANDLER SCOTT (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Address;Adult;Age;American;Anxiety;Appearance;assigned female at birth;assigned male at birth;Award;Biopsy;Birth;Breast;Breast Cancer Detection;Breast Cancer Risk Factor;breast imaging;Callback;cancer care;cancer health disparity;career;Caring;Chest Mass;cis-female;cis-male;cisgender;Clinic;cohort;Cohort Studies;Collaborations;Communities;Consensus;Coupled;Data;Databases;Decision Making;Dedications;design;Detection;Development;Electronics;Equity;Estrogens;evidence base;experience;Exposure to;Face;Faculty;Focus Groups;Foundations;Funding;Future;Gender;gender affirming hormone therapy;Gender Identity;Goals;Health;health belief;Health Personnel;Healthcare Systems;Hormonal;Image;improved;Incidence;Individual;Inferior;innovation;insight;Institution;Interview;Knowledge;Lesbian Gay Bisexual Transgender Queer;Lesion;lifetime risk;Literature;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammary Ultrasonography;Mammographic screening;Mammography;Mass in breast;Mediating;Medical;men;Mental Health;Mentors;Mentorship;Methods;Minority Groups;Modeling;novel;Operative Surgical Procedures;Participant;participant interview;Pathology;Perception;Persons;Population;Practice Guidelines;prevent;Process;process improvement;programs;prospective;Prospective cohort;Provider;psychologic;psychosocial;Qualitative Methods;Radiology Specialty;recruit;Registries;Reporting;Research;Research Design;Research Proposals;Risk;Risk Factors;Role;routine screening;Scientist;screening;Screening for cancer;screening guidelines;screening program;Sensitivity and Specificity;sex;sex assigned;skills;social;Stage at Diagnosis;Stigmatization;Suggestion;Surgeon;Surveys;system-level barriers;Testosterone;Time;Tissues;Training;Training and Education;transgender;transgender men;transgender women;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: Understanding Breast Cancer Risk and Screening in Transgender Persons through a Pilot Breast Cancer Screening Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

ORG_CITY: TORONTO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: HOSPITAL FOR SICK CHLDRN (TORONTO)

ORG_STATE: ON

ORG_ZIPCODE: M5G 1X8

PHR: THREE SENTENCE NARRATIVE We propose to analyze the timing and order of mutations in sarcomas, tumors that disproportionately affect children. Our premise, based on strong published and unpublished data, is that by understanding when and how a child’s sarcoma develops, we will ultimately be able to predict how it will change, how it will respond to therapy and whether it will recur. 1

PI_NAMEs: SHLIEN, ADAM  (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Adult;Affect;Age;Area;Award;Benign;bioinformatics pipeline;Biological Assay;Biopsy;bone;Bone neoplasms;Bone Tissue;Categories;Cells;Cellular Morphology;Child;Childhood;childhood sarcoma;Clinical;Clinical Data;clinical practice;cohort;Collection;Connective Tissue;Data;Decision Making;Detection;Development;Diagnosis;DNA;Early identification;Early Intervention;early onset;Evaluation;Face;Foundations;Future;Gene Fusion;Generations;genetic signature;genome sequencing;Growth;high risk;Immunohistochemistry;improved;in utero;interest;Learning;Malignant - descriptor;Malignant Bone Neoplasm;Malignant Neoplasms;Massive Parallel Sequencing;Measurement;Measures;Modeling;Molecular;Molecular Target;Mutation;Neoplasm Metastasis;novel;Oncogenic;Oncology;Osteosarcoma;Paint;Pathologic Mutagenesis;Pathologist;Patients;Pattern;Phylogenetic Analysis;premalignant;Process;Proliferating;prospective;Publishing;rare cancer;reconstruction;Recurrence;Recurrent disease;Relapse;repository;Research;RNA;Sampling;Sarcoma;soft tissue;Somatic Mutation;Specialist;Specimen;Therapeutic;Therapeutic Intervention;Time;Training;Trees;tumor;tumor initiation;tumorigenesis;unpublished works;whole genome

PROJECT_TITLE: Discovering the Timing and Origins of Bone and Soft Tissue Cancers

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Health Effects of Indoor Air Pollution

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECT NARRATIVE Poor remediation of abandoned commercial uranium (U) mines throughout the Southwestern United States has subjected surrounding communities to metal-based (U, V, As) environmental exposures. Recent data suggest that inhalation of fugitive metal-based dust may have systemic impacts, driven by extracellular vesicles. The proposed research intends to explore the relationship and mechanisms between PM-driven extracellular vesicles and vascular and neurovascular consequences.

PI_NAMEs: ZYCHOWSKI, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Acute;Air Pollution;air quality regulation;Airborne Particulate Matter;Arizona;Arsenic;Automobile Driving;Autophagocytosis;Biogenesis;Biological;Biological Assay;Biological Markers;Biology;Blood - brain barrier anatomy;Blood Vessels;California;Chronic;climate change;Clinical;clinical translation;cohort;Communities;community collaboration;community partners;Complement;cytokine;Data;Disease;Dust;dust storms;Endocytosis;endothelial dysfunction;Endothelium;Environmental Exposure;Epidemiology;Exhibits;exposed human population;Exposure to;extracellular vesicles;fine particles;Flow Cytometry;Functional disorder;Gases;Health;Health Sciences;Home;Homeostasis;Human;In Vitro;in vivo;Inflammation;Inflammatory;Ingestion;Inhalation;Inhalation Exposure;innovation;intercellular communication;Laboratories;Link;Lipids;Lung;lung basal segment;Medical center;Medicine;Metabolism;Metal exposure;Metals;meter;Methodology;microchip;Mining;Molecular;Molecular Profiling;Native Americans;Nervous System Disorder;neurovascular;New Mexico;Nickel;novel;Occupational;Outcome;outreach;Particulate;Particulate Matter;Pathologic;Pathology;Pathway interactions;Physiological Processes;Population;Pulmonary Pathology;Recording of previous events;remediation;Research;Research Project Grants;Residual state;Resources;response;Role;Science;Seasons;Serum;Site;Source;Southwestern United States;superfund site;Suspensions;Testing;Toxic effect;Toxicology;Triglycerides;United States;Universities;uptake;Uranium;Vanadium;Vascular Diseases;Vascular System;wasting;Water;Work

PROJECT_TITLE: Systemic Implications and Novel Mechanisms of Circulating Extracellular Vesicles Following Inhaled Exposures

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Urologic Diseases

ORG_CITY: DURHAM

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Public Health Statement: Duke University, a major research university in Durham, NC, supports a career development program focused on benign urologic conditions, a major public health concern. Early career scientists will receive formal mentoring and training to conduct multidisciplinary research relevant to benign urology. These well-trained scientists will become the future leaders researching the underlying causes of benign urologic conditions and developing better treatments.

PI_NAMEs: AMUNDSEN, CINDY  (contact)

PROGRAM_OFFICER_NAME: REYNOLDS, WILLIAM STUART

PROJECT_TERMS: Address;Advisory Committees;Area;Benign;career;career development;Childhood;Clinical Research;Collaborations;Communities;Competence;data management;Development Plans;Disease;early-career faculty;Environment;Evaluation;experience;Experimental Designs;Feedback;Fostering;Foundations;Functional disorder;Funding;Goals;hands on research;Health Services Research;improved;Individual;Inflammation;Institution;Interdisciplinary Study;Journals;K-Series Research Career Programs;Knowledge;Lead;Leadership;Lower urinary tract;Medicine;Mentors;Methods;Monitor;multidisciplinary;next generation;Peer Review;Postdoctoral Fellow;programs;Publishing;Recommendation;recruit;Regenerative Medicine;Research;Research Personnel;Research Training;responsible research conduct;statistics;Structure;symposium;Systems Biology;Time;Training;Translational Research;Underrepresented Populations;Urinary tract infection;Urology;Writing

PROJECT_TITLE: Duke KURe Program


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Mental Health;Mental Illness

ORG_CITY: AUSTIN

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Public Health Narrative Although negatively biased attention has a central theoretical and empirical role in the maintenance of depression, few treatments successfully target and improve this deficit. The current proposal builds upon our prior work and aims to conduct a well-powered efficacy trial to determine the potential of gamified and traditional Attention Bias Modification for the treatment of depression in adults.

PI_NAMEs: BEEVERS, CHRISTOPHER G (contact)

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: Adult;Aftercare;anxious;Area;Attention;attentional bias;Basic Science;behavior measurement;Clinical Trials;Cognitive;cognitive training;confirmatory trial;Data;Data Analytics;Depressed mood;depressive symptoms;Development;Effectiveness;efficacious treatment;efficacy evaluation;efficacy testing;efficacy trial;experience;follow-up;Funding;gaze;Goals;improved;insight;Intervention;Interviewer;Investigational Therapies;Literature;Maintenance;Major Depressive Disorder;Measures;Mediating;Mediation;Mediator;Mental Depression;Mental Health;Methods;mobile application;Modification;National Institute of Mental Health;negative affect;Outcome;Patient Self-Report;Persons;Population;prevent;Protocols documentation;Psychopathology;psychosocial;Public Health;Publishing;Quality of life;randomized, clinical trials;Recovery;reduce symptoms;Reporting;Research;response;Role;Sampling;Severities;Signal Transduction;Stimulus;sustained attention;symptom treatment;Symptoms;Testing;therapy development;Training;Treatment Protocols;trial comparing;visual tracking;Work

PROJECT_TITLE: Confirmatory Efficacy Trial of a Traditional vs. Gamified Attention Bias Modification for Depression


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: AMES

ORG_DEPT: CHEMISTRY

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: Narrative. This work develops new methods for the combinatorial synthesis of glycan microarrays. Because glycans are involved in numerous biological processes such as cellular trafficking, signaling, cancer metastasis, viral entry, and immune defense, etc., such a technological breakthrough will have immediate impact on human health by helping to understand the target epitopes of glycan binding partners, and accelerate efforts to uncover the structure and function of the glycome.

PI_NAMEs: WINTER, ARTHUR H. (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TITLE: Chromatically Orthogonal Photolabile Protecting Groups for the Parallel On-Chip Synthesis of High-Density Glycan Microarrays

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: SAN DIEGO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: SAN DIEGO STATE UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed research will identify the neurobiobehavioral mechanisms underlying sensory and salience processing and stress reactivity in 7- to 10-year-old children with ASD. The findings will reveal how sensory aberrations in low-level (visual, auditory, tactile) processing disrupt both high-level multisensory integration and detection of salient sensory information, and how multisensory and salience dysfunction—moderated by stress reactivity—are associated with internalizing behaviors. The research findings may ultimately contribute to the development or refinement of therapies including current sensory-based interventions and practices to ameliorate sensory dysfunction and co-occurring internalizing symptomatology in autism.

PI_NAMEs: JAO KEEHN, R. JOANNE  (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: 10 year old;aged;Anatomy;Anxiety;Area;Auditory;autism spectrum disorder;autistic children;Behavior;behavior measurement;Behavioral;Behavioral Mechanisms;behavioral response;Biological;biological adaptation to stress;Caregivers;Child;Cognitive;Collection;Complex;Cues;Data;Detection;Development;diagnostic criteria;directed attention;Discrimination;discrimination task;Emotional;Environment;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Hydrocortisone;Impairment;indexing;information gathering;information processing;Intervention;Link;Magnetic Resonance Imaging;Maps;Measures;Mental Depression;Modality;MRI Scans;multimodality;multisensory;neural;neural circuit;neuromechanism;Pattern;peer;Psychophysics;Questionnaires;Reaction Time;Reporting;Research;Research Project Grants;response;Rest;Risk;Salivary;Sensory;sensory discrimination;sensory input;sensory integration;Severities;social;somatosensory;Stress;stress reactivity;symptomatology;Symptoms;Tactile;theories;Uncertainty;Visceral;Vision;Visual

PROJECT_TITLE: Neurobiobehavioral markers of stress, saliency, and multisensory dysfunction in autism

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Primary Health Care

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Narrative / Public Health Relevance  Data and metrics for evaluating retention and engagement in clinical care among persons with HIV have yet to be optimized for distinct sub-populations in an era of changing data availability, new primary care models, and remote clinic visit modalities. Applying the proposed epidemiologic modeling methods to the largest HIV cohort in the US, the North American AIDS Cohort Collaboration on Research and Design, will elucidate appropriate retention and engagement metrics for different groups. This research will be novel and high-impact, generating evidence to inform programs and policies which will create benchmarks for, and ultimately improve, HIV care nationwide.

PI_NAMEs: ALTHOFF, KERI NICOLE;REBEIRO, PETER F (contact)

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;American;Benchmarking;Black Populations;care delivery;Caring;Categories;CD4 Lymphocyte Count;Cells;Classification;Clinic Visits;Clinical;clinical care;Clinical Management;cohort;Collaborations;comorbidity;Consensus;Continuity of Patient Care;COVID-19 pandemic;Critical Care;Data;design;Disease;Disease Management;Disease Outcome;Disparity;epidemiological model;Ethnic Origin;eVisit;experience;Failure;Frequencies;Growth;Guidelines;health disparity;Health Policy;high risk behavior;Hispanic Populations;HIV;HIV disparities;HIV Infections;HIV-1;improved;Income;Individual;Laboratories;Light;Link;Measurement;Measures;men who have sex with men;Methods;Modality;Modeling;Modernization;Monitor;Morbidity - disease rate;mortality;North America;novel;Outcome;Patients;Pattern;Patterns of Care;Persons;Policies;Population;population stratification;Primary Care;primary care visit;programs;Public Health;public health relevance;Quality of Care;Race;Recommendation;Research;Risk;RNA;Services;sexual risk behavior;Techniques;telehealth;theories;Time;transmission process;United States;Update;Viral;Viral Load result;Visit;Work

PROJECT_TITLE: Retaining relevance: extending clinical retention measures to improve their utility in describing HIV care engagement in the United States

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Human Genome;Kidney Disease;Pediatric;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE This proposal will examine how metabolites previously associated with cardiac outcomes in pediatric chronic kidney disease relate to genetic variation, and if they have causal effects on the development of adverse cardiac outcomes, leading to new understanding cardiac biochemical pathophysiology in pediatric CKD.

PI_NAMEs: LEE, ARTHUR  (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Acetyltransferase;Adult;Age;aged;Alanine;Biochemical;Bioinformatics;Biological Markers;Biometry;Biostatistical Methods;Cardiac;Cardiology;Cardiovascular Diseases;cardiovascular injury;cardiovascular risk factor;Cardiovascular system;career;career development;causal variant;Cessation of life;Child;Child Mortality;Childhood;Chronic Kidney Failure;Clinical;Clinical Data;clinical practice;Clinical Research;Computational Biology;Data;data resource;Development;Echocardiography;Enrollment;Enzymes;Epidemiology;Etiology;Faculty;Feedback;Functional disorder;Funding;Future;Genes;Genetic;Genetic Variation;genome wide association study;genomic data;Genomics;Genotype;Glomerular Filtration Rate;Goals;Grant;Height;High Prevalence;indexing;instrument;Intervention;Investigation;K-Series Research Career Programs;Knowledge;Learning;Left;Left Ventricular Hypertrophy;Left Ventricular Mass;Link;Manuscripts;Measures;Mediation;medical schools;Mendelian randomization;Mentors;Mentorship;Metabolic;metabolic phenotype;metabolomics;Methods;molecular phenotype;mortality;multiple omics;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;Outcome;Pathogenesis;Pediatric Hospitals;Pennsylvania;Philadelphia;Plasma;Population;pressure;Prevention;preventive intervention;Prognostic Marker;Program Development;programs;Prospective cohort;Prospective, cohort study;Protocols documentation;Research;Research Personnel;Research Training;Risk;Risk Factors;Science;sex;Shortening Fraction;Single Nucleotide Polymorphism;skill acquisition;skills;symposium;targeted treatment;therapeutic development;therapeutic target;tool;Training;Translating;Translational Research;United States National Institutes of Health;Universities;Ventricular Dysfunction;Work;working group

PROJECT_TITLE: Identifying genetic drivers of circulating metabolites associated with cardiac risk in pediatric chronic kidney disease


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: MADISON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: PROJECT NARRATIVE Building on a ten-year history of successful progress, the K12 training program will continue advanced training in clinical and basic science approaches and expand recruitment and training of scholars in population health and dissemination and implementation sciences in an environment that is ideally suited for professional skills development, building networking opportunities with researchers across the country, and matriculating independent researchers in benign urology with diverse expertise.

PI_NAMEs: VEZINA, CHAD M. (contact)

PROJECT_TERMS: Benign;career development;Clinical Research;Collaborations;Development;Environment;experience;Faculty;Funding;Goals;improved;Institution;Interdisciplinary Study;International;Mentored Clinical Scientist Development Program;Mentors;multidisciplinary;Program Development;programs;recruit;Research;Research Personnel;Research Support;Scientist;success;summer program;tenure track;Training;Translational Research;undergraduate student;United States National Institutes of Health;Universities;urologic;Urology;Wisconsin

PROJECT_TITLE: Wisconsin Multidisciplinary K12 Urologic Research Career Development Program


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dietary Supplements;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Nutrition;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_CITY: IRVINE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Our proposal targets secondary prevention of cervical cancer with the long-term goal of mitigating high-risk HPV persistence, risk of cervical cancer, and improving the health of women co-infected with HPV and HIV. The proposed comprehensive ASHA-Health HPV intervention builds on a highly successful and long-term US-Indo collaboration with a high potential for scale-up in India. Success of this intervention will lead to policy development and further cervical cancer prevention trials among co-infected Indian women.

PI_NAMEs: EKSTRAND, MARIA L.;NYAMATHI, ADELINE M (contact);SATYANARAYANA, VEENA A

PROGRAM_OFFICER_NAME: SAHASRABUDDHE, VIKRANT V

PROJECT_TERMS: acceptability and feasibility;antiretroviral therapy;Appointment;cancer prevention;Cancer Prevention Trial;cancer risk;care seeking;Caring;CD4 Lymphocyte Count;CD4 Positive T Lymphocytes;Cell Count;Cells;Cervical;cervical cancer prevention;Cervical Intraepithelial Neoplasia;Cervix Uteri;Chronic;Clinical;co-infection;Collaborations;community advisory board;Community Health Aides;Coupled;Data;depressive symptoms;design;Development;Dietary Intervention;dietary supplements;Education;efficacy evaluation;Emotional;Focus Groups;follow-up;food insecurity;Food Supplements;Fortified Food;future implementation;Goals;Health;Health Promotion;high risk;High Risk Woman;High-Risk Cancer;HIV;HIV/AIDS;HPV screening;HPV-High Risk;Human papilloma virus infection;Human Papillomavirus;Immune;immune activation;Immune response;Immunologics;Impairment;implementation science;implementation trial;improved;Incidence;indexing;India;internalized stigma;Intervention;intervention effect;Iron;Lesion;Link;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Malnutrition;Measures;Mediating;Mental Depression;Mental Health;Modeling;Nurses;nutrition;nutrition education;Nutritional;Nutritional Support;Odds Ratio;Outcome;Participant;Play;Policy Developments;premalignant;prevent;preventable death;primary outcome;programs;Proliferating;Proteins;psychologic;Psychosocial Assessment and Care;psychosocial outcome;Randomized;randomized, clinical trials;Recovery;Research;Risk;Risk Factors;Risk Reduction;Role;Rural;scale up;Screening for cancer;Secondary Cancer Prevention;secondary outcome;Secondary Prevention;Serum Albumin;Services;skills;social stigma;Social support;standard of care;success;Testing;Thinness;Training;treatment adherence;treatment as usual;treatment center;tumorigenesis;two-arm study;Viral;Viral Load result;Vitamin A;Vitamin D;Woman;women's diagnosis;Women's Health;women's outcomes;women's treatment

PROJECT_TITLE: Secondary Cervical Cancer Prevention of Vulnerable Women with HPV and HIV Co-infection in India

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Diabetes;Emerging Infectious Diseases;Health Services;Infectious Diseases;Nutrition;Patient Safety;Pediatric;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention

PHR: Project Narrative Recent studies have found that infection with SARS-CoV-2 and COVID-19 diagnosis are associated with the development and progression of both Type 1 (T1D) and Type 2 Diabetes (T2D). The proposed study will engage 15 sites from the National Patient-Centered Clinical Research Network (PCORnet) and the T1D Exchange to recruit 1600 English- and Spanish-speaking pediatric and adult patients with recently diagnosed T1D or T2D who have had a known COVID-19 infection in the past 90 days or no recent diagnosis of COVID- 19 infection in the past year. The study will follow this population for 2 years and will utilize linked electronic health data from PCORnet sites to understand the impact of COVID-19 on diabetes.

PI_NAMEs: BLOCK, JASON PERRY;POWERS, ALVIN C;ROTHMAN, RUSSELL L. (contact);SCHILDCROUT, JONATHAN SCOTT

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: 2019-nCoV;Adult;American;Antibodies;Area;Beta Cell;Biological Markers;Biological Process;Blood Vessels;CDC42 gene;Cell Physiology;Cessation of life;Child;Childhood;Childhood diabetes;Clinical;Clinical Research;cohort;community engagement;Consent;COVID-19;COVID-19 diagnosis;COVID-19 impact;COVID-19 pandemic;COVID-19 patient;COVID-19 sequelae;COVID-19 surveillance;COVID-19 test;COVID-19 treatment;Data;data hub;Deterioration;Development;Diabetes Mellitus;Diagnosis;drug repurposing;electronic health data;Electronic Health Record;Environmental Risk Factor;Epidemiology;epidemiology study;experience;Family;Fibrosis;Funding;Future;Genomics;Glucose tolerance test;glycemic control;Health;Health Services Research;Health system;improved;Individual;Infection;Inflammation;Informatics;Infrastructure;Insulin Resistance;Insulin-Dependent Diabetes Mellitus;Internet;Intervention;Intervention Studies;Link;Long COVID;member;Metabolic;metabolomics;Multicenter Trials;Non-Insulin-Dependent Diabetes Mellitus;Nucleocapsid;Obesity;Observational Study;Outcome;Outpatients;pandemic disease;Participant;patient oriented;patient portal;patient registry;patient subsets;Patients;Physiological;Physiology;Population;Post-Acute Sequelae of SARS-CoV-2 Infection;Process;Public Health;Records;recruit;Registries;Research;Resources;Risk;Role;SARS-CoV-2 exposure;SARS-CoV-2 infection;SARS-CoV-2 negative;Serology test;Site;social;Spanish/English;Standardization;Structure;Study Subject;Surveys;Telephone;Testing;Thrombophilia;Time;type 2 diabetes in children;type I and type II diabetes;United States National Institutes of Health;Work

PROJECT_TITLE: CODA: COvid and Diabetes Assessment


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Lymphatic Research

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Naïve T cell numbers are dramatically decreased with age, leading to impaired immune responses in the elderly. Naïve T cells rely on signals from the lymph node tissue environment to survive, yet it is unknown whether this support is reduced with age. This project will determine how age-related changes to the structural organization of the lymph nodes contributes to reduced naïve T cell survival.

PI_NAMEs: LANCASTER, JESSICA N (contact)

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: Adoptive Transfer;Adult;Age;age effect;age related;age related changes;age related decline;aged;Aging;aging process;antifibrotic treatment;Architecture;Atrophic;Automobile Driving;Binding;CCL19 gene;CCL21 gene;Cell Aging;Cell Count;Cell Culture Techniques;Cell Differentiation process;Cell Maintenance;cell motility;Cell Survival;cell type;Cells;chemokine;Chronic;Clinical;Collagen;Communicable Diseases;cytokine;Data;density;Development;draining lymph node;efficacy testing;Elderly;emerging pathogen;Environment;Fibrosis;flexibility;Frequencies;Goals;Homeostasis;Human;IL7 gene;Image;Immune;Immune response;Immunity;Immunologics;Impairment;improved;In Situ;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Knowledge;Ligands;Link;live cell microscopy;lymph node microenvironment;Lymph Node Tissue;lymph nodes;Lymphocyte;lymphotoxin beta;lymphotoxin beta receptor;migration;Molecular;Motility;Mus;novel strategies;old mice;Older Population;Outcome;Output;pathogen;Pathway interactions;Phenotype;Population Decreases;Process;Proliferating;Receptor Signaling;recruit;Reticular Cell;Role;Signal Transduction;Stromal Cells;Structure;T-Lymphocyte;Testing;therapeutic development;Three-Dimensional Imaging;Time;Tissues;Tumor Necrosis Factor Receptor;two photon microscopy;two-photon;Visualization;Work

PROJECT_TITLE: The role of lymph node structural organization in naïve T cell decline with age

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: Aurora

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE Autoimmune T cell responses specific to neoepitopes formed in peripheral tissues may explain how and why T cell responses break the usual tolerance mechanisms. This project investigates how disulfide modified antigens elicit autoimmune T cell responses and how redox regulation may impact disulfide modified antigen presentation. The study could provide novel therapeutic strategies to prevent or treat type 1 diabetes.

PI_NAMEs: DAI, SHAODONG  (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: adrenomedullin;Age;Amino Acid Sequence Homology;Amino Acids;Antigen Presentation;Antigen Targeting;Antigens;Autoantigens;Autoimmune;Autoimmunity;Binding;Biological Assay;Calcitonin Gene-Related Peptide;CD4 Positive T Lymphocytes;Cells;Clone Cells;cohort;Complex;Cysteine;cytokine;Data;deamidation;Development;Diabetes Mellitus;diabetes pathogenesis;diabetic;diabetogenic;Disease;disulfide bond;Disulfides;Education;endoplasmic reticulum stress;enzyme linked immunospot assay;Epitopes;Flow Cytometry;Generations;Genetic Polymorphism;Goals;Histocompatibility Antigens Class II;HLA-DR Antigens;Human;Immune;improved;Inbred NOD Mice;Individual;Inflammatory;insight;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;islet;islet amyloid polypeptide;islet cell antibody;Islets of Langerhans;lymph nodes;MHC Class II Genes;molecular phenotype;mouse model;Mus;N-terminal;neoantigens;new therapeutic target;Newly Diagnosed;non-diabetic;novel therapeutic intervention;Oxidation-Reduction;Pancreas;Pathogenicity;Patients;Peptides;Peripheral;peripheral blood;Phenotype;Post-Translational Protein Processing;Prediabetes syndrome;prevent;Process;Proteins;Reactive Oxygen Species;Regulation;Resolution;Risk;Sampling;secretory protein;sex;single-cell RNA sequencing;Specificity;Stains;Structure;Structure of beta Cell of islet;T cell response;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Epitopes;therapeutic target;Thymus Gland;Time;Tissues;transcriptome sequencing

PROJECT_TITLE: Characterization of disulfide modified diabetogenic neoepitopes

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Immunotherapy;Physical Injury - Accidents and Adverse Effects

ORG_CITY: NEW YORK

ORG_DEPT: ORTHOPEDICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative Tendon ruptures and tendinopathies are painful and debilitating conditions affecting a large portion of the adult population. From a regenerative standpoint, there is a pressing clinical need to identify the cell and molecular mechanisms regulating tendon differentiation vs fibrotic scarring in order to improve repair outcomes. Since the local immune environment and T cells are implicated in both effective and poor tendon healing, the objective of the proposed studies is to fully define the T cell subpopulations underlying tendon healing and to test the role of IL33.

PI_NAMEs: HUANG, ALICE H (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Adoptive Transfer;Adult;Affect;Anti-Inflammatory Agents;Antigen-Presenting Cells;Biological;CD4 Positive T Lymphocytes;Cell Communication;Cells;Chronic;Cicatrix;Clinical;Collagen;Data;Dendritic Cells;Environment;Event;Exhibits;Fibrosis;Flow Cytometry;FOXP3 gene;functional restoration;Gait;Genetic;healing;Image;Immune;Immune response;immunological synapse;immunological synapse formation;immunoregulation;Impairment;improved;In Vitro;Inflammation;Inflammatory;Injury;Life;Macrophage;Mediating;migration;Modeling;Molecular;Mus;Myofibroblast;Natural regeneration;Neonatal;neonatal mice;neonate;novel;Outcome;Pain;Pathologic;permissiveness;Pilot Projects;Population;Proliferating;receptor-mediated signaling;Recombinants;Recovery;recruit;Recurrence;regenerative;Regulatory T-Lymphocyte;repaired;Research;Research Priority;Resolution;response;Role;Rupture;Signal Transduction;single-cell RNA sequencing;stem cells;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;TCF Transcription Factor;Tendinopathy;Tendon Injuries;tendon rupture;Tendon structure;Testing;Tissues;wound healing

PROJECT_TITLE: The role of T cells in tendon healing


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE This project aims to improve early diagnosis of colorectal cancer polyps by development of a novel and soft tactile sensing device and complementary intelligent algorithms. The proposed transformative diagnosis framework (1) readily integrates with the existing colonoscopic systems and does not change the current clinical diagnosis workflow, (2) provides high-resolution 4D imaging (i.e., 3D texture mapping + stiffness classification), (3) dramatically decreases polyp diagnosis miss-rate, and (4) enhances in vivo polyps’ type and stage classification.

PI_NAMEs: ALAMBEIGI, FARSHID  (contact)

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: 3-Dimensional;4D Imaging;Address;Algorithms;Anatomy;Area;biomaterial compatibility;Biopsy;Cancer Center;Cancer Etiology;cancer type;Cessation of life;Characteristics;chemotherapy;Classification;Clinical;clinical diagnosis;Colon;colon cancer patients;Colonoscopy;Colorectal Cancer;Colorectal Neoplasms;Computer Vision Systems;Confusion;design;Detection;Development;Devices;Diagnosis;diagnostic platform;Early Diagnosis;Elasticity;Endoscopes;Ensure;Evaluation;Excision;experimental study;fabrication;Feedback;Gastrointestinal Polyp;Geometry;Goals;Image;improved;in vivo;Incidence;innovation;intelligent algorithm;Intuition;Machine Learning;machine learning algorithm;Malignant neoplasm of gastrointestinal tract;Maps;Medical;microscopic imaging;Modulus;Morphology;mortality;novel;Operative Surgical Procedures;Output;Performance;Polyps;Precancerous Polyp;preclinical evaluation;Procedures;Qualitative Evaluations;Quantitative Evaluations;Radiation;Radiation therapy;Resected;Resolution;response;Review Literature;Robotics;screening;sensor technology;Shapes;Surface;Surgeon;survival outcome;System;Tactile;Technology;Testing;Texture;Three-Dimensional Image;Time;timeline;Treatment outcome;treatment stratification;tumor;Tumor stage;Vision;Visual

PROJECT_TITLE: A Novel Framework for Sensitive and Reliable Early Diagnosis, Topographic Mapping, and Stiffness Classification of Colorectal Cancer Polyps

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ORG_CITY: SEATTLE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Type 1 diabetes research focuses on predicting who will get the disease, preventing disease in those at risk, and reducing the chances of heart attacks, amputations, blindness, and kidney disease in people who survive with the disease. Unfortunately, many of the blood tests that are used to investigate or treat type 1 diabetes are not reproducible in other laboratories, or they give very different results compared with assays made by other companies. This project aims to make new blood tests that researchers and clinical laboratories can easily recreate at their own institutions, which will make research findings more reproducible and will help facilitate their translation into patient care.

PI_NAMEs: HOOFNAGLE, ANDREW N (contact);MACCOSS, MICHAEL

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: Address;Adoption;Affect;Affinity;Age;Algorithms;Amino Acids;Amputation;analog;Antibodies;Area;Autoimmune Diseases;Autoimmunity;Beta Cell;Biological Assay;Biological Markers;biological research;Blindness;Blood Glucose;Blood Tests;burden of illness;Calibration;caucasian American;Characteristics;Child;Chromatography;Chromogranins;Clinical;clinical care;Clinical Chemistry;Clinical Investigator;Clinical Research;Collaborations;Community Healthcare;Data;Democracy;Deposition;Detection;detection limit;Development;Diabetes Mellitus;Diagnosis;Digestion;Disease;disorder prevention;disorder risk;Emotional;Ensure;Enzyme-Linked Immunosorbent Assay;Epidemiology;experience;experimental study;extracellular vesicles;Family;Financial Hardship;Genetic;Glucagon;glycation;Guidelines;Healthcare Systems;High Pressure Liquid Chromatography;Human;Hybridomas;Hyperglycemia;Hypoglycemia;Immunoassay;Immunologic Factors;improved;In Vitro;Incidence;Individual;Injectable;Institution;instrument;Insulin;Insulin-Dependent Diabetes Mellitus;interest;Intervention;Iowa;islet amyloid polypeptide;Islets of Langerhans;Kidney Diseases;Laboratories;Laboratory Study;Lead;Liquid Chromatography;macrovascular disease;Mass Spectrum Analysis;Measurement;Measures;method development;Methods;Molecular;Monoclonal Antibodies;mouse model;multiplex assay;Myocardial Infarction;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Organ;Pancreas;Patient Care;Patients;Peptides;Periodicals;personalized medicine;Persons;Phase;Plasma;Plasmids;Population;Post-Translational Protein Processing;preclinical study;prevent;Procedures;Process;proglucagon;Proinsulin;Protein Biosynthesis;protein expression;Proteins;Proteolysis;Publishing;Reagent;Reproducibility;Research;Research Design;Research Personnel;response;Risk;Sampling;Serum;Solid;Source;Specificity;stressor;Study models;tandem mass spectrometry;Technology;Testing;Thinness;tool;Translating;Translational Research;Translations;Trypsin;United States;United States National Institutes of Health;Universities;Validation;validation studies;Western Blotting;Work

PROJECT_TITLE: Quantifying proteins in plasma do democratize personalized medicine for patients with type 1 diabetes


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Dietary Supplements;Genetics;Heart Disease;Human Genome;Nutrition;Pediatric;Prevention;Rare Diseases;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: Project Narrative Identification of the mechanisms responsible for many structural birth defects is hindered by the complex genetics of these disorders, where genetic mutations interact with genetic and environmental factors. Proposed studies will elucidate how genes and environment interact to converge on progenitor cell development to cause structural birth defects. This understanding is vital for devising strategies to prevent birth defects.

PI_NAMEs: ZOHN, IRENE E (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Affect;Alleles;Animals;aortic arch;Arteries;Back;Binding Proteins;Black Box;Branchial arch structure;Cardiac;cardiogenesis;Cells;Complex;Congenital Abnormality;Congenital Heart Defects;Data;Defect;Development;Developmental Process;Diet;Disease;disease model;DNA Sequence Alteration;Embryo;Embryonic Development;Environment;Environmental Risk Factor;Etiology;Experimental Designs;experimental study;feeding;Gene Dosage;gene environment interaction;Gene Expression;Genes;Genetic;Genetic Diseases;genetic variant;Heart;Heterozygote;Human;human model;In Situ;In Situ Hybridization;in vivo evaluation;Intake;Laboratories;Link;Live Birth;malformation;Micronutrients;Modeling;mother nutrition;Mothers;mouse model;Mus;Mutagenesis;mutant;mutant mouse model;Mutant Strains Mice;Mutation;novel;Patients;personalized strategies;Phenotype;Positioning Attribute;premature;Prevalence;prevent;Prevention strategy;progenitor;Proteins;Publishing;receptor binding;Retinoic Acid Receptor;Risk Reduction;Series;Signal Transduction;single-cell RNA sequencing;Stem Cell Development;stem cell differentiation;stem cell fate;stem cells;Structural Congenital Anomalies;Testing;Time;Tretinoin;ubiquitin ligase;Vitamin A;Vitamin A Deficiency;Work

PROJECT_TITLE: Gene x Environment Interactions and Congenital Heart Defects – Illuminating the Mechanisms

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Lung;Orphan Drug;Pediatric;Pediatric - AIDS;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: PITTSBURGH

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Tuberculosis (TB) is a major global health threat, especially for people living with HIV and BCG, the current TB vaccine, typically provides only poor protection. Here, we will use a macaque model of TB, both with and without an SIV infection, to explore vaccination with BCG, as well as the more attenuated BCG? 1419c, delivered to the respiratory mucosa rather than the standard intradermal route. Both TB vaccines will be assessed for safety, immunogenicity, and protective efficacy to guide the development of a safer, more efficacious, TB vaccine.

PI_NAMEs: NDHLOVU, LISHOMWA C;OCONNOR, SHELBY L;SCANGA, CHARLES A. (contact)

PROGRAM_OFFICER_NAME: DANG, QUE

PROJECT_TERMS: 2 year old;Adolescent;Adult;Age;Animal Model;Animals;Attenuated;Bacille Calmette-Guerin vaccination;BCG Live;BCG Vaccine;Biological Assay;Bronchoscopes;Cavia;Child;Childhood;Clinical;clinical translation;co-infection;Communicable Diseases;Data;design;Development;Disease;Ensure;Epigenetic Process;Flow Cytometry;global health;guinea pig model;HIV;Immune system;Immunity;Immunocompromised Host;immunogenic;immunogenicity;Immunology;Immunology procedure;immunosuppressed;improved;Individual;Infant;Infection;Intravenous;intravenous injection;Licensing;Macaca;Macaca fascicularis;Mass Vaccinations;mature animal;Measures;Modeling;Monitor;Morbidity - disease rate;mortality;Mucous Membrane;Mus;Mycobacterium tuberculosis;novel;Nude Mice;Pathology;pediatric human immunodeficiency virus infection;Persons;PET/CT scan;Population;predicting response;Predisposition;prevent;Productivity;programs;protective efficacy;Pulmonary Tuberculosis;Recombinants;Respiratory Mucosa;Risk;Route;Safety;safety assessment;Scientist;Serology;Side;single-cell RNA sequencing;SIV;Testing;Tuberculosis;Tuberculosis Vaccines;Vaccinated;Vaccination;vaccine candidate;vaccine efficacy;vaccine safety;vaccine strategy;vaccine trial;Vaccines;Virulent;Vulnerable Populations;X-Ray Computed Tomography

PROJECT_TITLE: Defining the Immunogenicity and Efficacy of a Durable BCG Vaccine Strategy Optimized for Preventing TB in Pediatric HIV Infection


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Infectious Diseases;Lung;Prevention

PHR: NARRATIVE Infection with human rhinoviruses (HRVs) may render individuals less susceptible to infection or severe illness associated with heterologous respiratory viruses; however, most existing studies that evaluate these interactions utilize animal models or in vitro experiments. This proposal seeks to leverage our unique platform of intensive case-based SARS-CoV-2 household surveillance in order to test the central hypothesis that coinfection of HRV with SARS-CoV-2 may be associated with reduced transmission of SARS-CoV-2, reduced risk of symptomatic SARS-CoV-2 infection, and reduced clinical symptoms among symptomatic infected individuals. A detailed understanding of the impact of HRV coinfection with SARS-CoV-2 in real-world conditions may yield new insights into both the immunological consequences of HRV infections and also the individual and age-associated variability in SARS-CoV-2 susceptibility to infection and severe illness.

PI_NAMEs: GRIJALVA, CARLOS G;HOWARD, LEIGH MEREDITH (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 2019-nCoV;Adult;Age;age difference;age related;Animal Model;Attenuated;case-based;Cells;Cessation of life;Child;chronic infection;Circulation;Clinical;clinically relevant;co-infection;COVID-19;COVID-19 pandemic;COVID-19 susceptibility;Development;Disease;experience;Experimental Models;experimental study;Frequencies;Health;Hospitalization;Household;Human;Immunologics;In Vitro;indexing;Individual;individual variation;Infection;Inflammatory;Influenza;innovation;insight;Interferons;Kinetics;Longitudinal cohort;Measures;Mediating;member;Nose;pandemic disease;Pathogenesis;Pattern;Phase;Predisposition;prevent;Prevention strategy;Recording of previous events;reduce symptoms;Reporting;respiratory;Respiratory syncytial virus;Respiratory Tract Infections;respiratory virus;response;Rhinovirus;Rhinovirus infection;Risk;Risk Reduction;Role;sample collection;Sampling;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;SARS-CoV-2 transmission;Secondary to;Seminal;severe COVID-19;Severity of illness;sociodemographic factors;Study models;Subgroup;symptomatic COVID-19;Symptoms;Testing;transmission process;Vaccination;Viral;Viral Interference;Virus;Virus Shedding;Work

PROJECT_TITLE: Human rhinovirus infection and susceptibility to SARS-CoV-2 infection and symptomatic disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-C(02)M]


NIH_SPENDING_CATS: Biotechnology;Cerebrovascular;Congenital Structural Anomalies;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: COLUMBIA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Project Narrative Port-wine birthmark (PWB) is a congenital progressive vascular malformation of the skin with an estimated prevalence of 3–5 children per 1,000 live births. This proposal aims to develop novel and clinically relevant cell and organoid models derived from patients’ induced pluripotent stem cells (IPSCs) and determine the causative pathways underlying the impaired cell-fate and lineage-specific differentiation in these models and PWB skin lesions.

PI_NAMEs: TAN, WENBIN  (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Abnormal Cell;Address;Animal Model;Animals;Arteries;Arteriovenous malformation;Axon;Basement membrane;Blood capillaries;Blood Vessels;Cell Differentiation process;Cell model;Cells;Cerebrovascular system;Characteristics;Child;Clinical;clinical development;clinically relevant;Collagen Fiber;Congenital Abnormality;Data;Defect;Dermal;Dermis;Development;Diameter;Dilatation - action;Disease;disease model;effective therapy;Endothelial Cells;endothelial stem cell;Epigenetic Process;Epilepsy;Evaluation;Evolution;Exhibits;Face;Feasibility Studies;Fibroblasts;Generations;Hemangioma;Impairment;Implant;implantation;In Vitro;in vitro Model;in vivo;in vivo evaluation;in vivo Model;induced pluripotent stem cell;innovation;Intervention;Lasers;Length;Lesion;Live Birth;lymphatic vessel;malformation;Modality;model development;Modeling;Molecular;molecular phenotype;Molecular Profiling;Monitor;Morphology;Mus;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;next generation sequencing;novel;Organoids;Pathogenesis;Pathologic;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Pericytes;Phenotype;Physicians;Plug-in;Port-Wine Stain;Prevalence;Probability;Proliferating;Research;revascularization;Scientist;Series;Severe Combined Immunodeficiency;Signal Pathway;Skin;skin lesion;Specific qualifier value;spheroids;Stains;stem cells;stemness;Strategic Planning;Sturge-Weber Syndrome;subcutaneous;Symptoms;Technology;therapeutic development;Therapeutic Studies;therapy outcome;tool;Validation;Veins;Xenograft procedure

PROJECT_TITLE: Generation and Validation of Disease Models for Port-Wine Birthmarks

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Genetics

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Mitochondria are membrane bound organelles which are critical for eukaryotic cellular function. This proposal describes how biochemistry and systematic functional genomics will be combined to look at how outer mitochondrial membrane a-helical proteins get made, an important class of proteins that mediate a range of processes such as mitochondrial-cytoplasmic communication, the innate immune response, and apoptosis. Knowledge about the biogenesis of these proteins will not only expand our understanding of basic cellular biology, but also aid in the development of treatments for diseases associated with outer mitochondrial membrane protein dysregulation such as Parkinson’s and Alzheimer’s disease.

PI_NAMEs: GUNA, ALINA-IOANA  (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: alpha helix;Alzheimer's Disease;Apoptosis;Award;Binding;Biochemical;biochemical tools;Biochemistry;Biogenesis;Bioinformatics;Biological Assay;biophysical properties;career;CCL21 gene;Cell Physiology;Cells;Cellular biology;Cellular Stress;Collaborations;Communication;Complex;crosslink;Cytoplasm;Data;Development;Disease;Eukaryota;Evolution;Family;Foundations;functional genomics;Future;Genetic;Genome;genome wide screen;genomic tools;Goals;Homeostasis;Homologous Gene;Human;human disease;hydrophilicity;Hydrophobicity;In Vitro;in vitro Assay;in vivo;Innate Immune Response;insight;Knowledge;Knowledge acquisition;Learning;Life;Lipid Bilayers;Lipids;Malignant Neoplasms;Mammalian Cell;Mammals;Maps;Mediating;member;Membrane;membrane biogenesis;Membrane Proteins;Mentors;Metabolism;Mitochondria;mitochondrial membrane;Mitochondrial Membrane Protein;Mitochondrial Proteins;Molecular;Mutagenesis;Neurodegenerative Disorders;novel;Nuclear;Organelles;Organism;Orthologous Gene;Outcome;Outer Mitochondrial Membrane;Parkinson Disease;Pathway interactions;peroxisome;Pharmacologic Substance;Phase;Physiological;Physiology;Play;Positioning Attribute;Postdoctoral Fellow;Process;Production;programs;Proteins;Proteome;Research;Role;Route;Signal Transduction;Site;skill acquisition;skills;solute;Techniques;Testing;therapy development;Time;Transmembrane Domain;Work

PROJECT_TITLE: Biogenesis of alpha-helical mitochondrial outer membrane proteins in higher eukaryotes


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BERKELEY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative For African Americans and whites with mental illness and serious psychological distress, this project will provide comprehensive, scientifically rigorous, estimates of insurance coverage and treatment rate increases nationwide from the Affordable Care Act (ACA). It will determine, for the first time how much Medicaid expansion, marketplaces and subsidies, and Federally Qualified Health Centers, key ACA components, reduced African American-white disparities in coverage and treatment.

PI_NAMEs: SNOWDEN, LONNIE ROSCOE (contact)

PROGRAM_OFFICER_NAME: HUMENSKY, JENNIFER L

PROJECT_TERMS: Address;Adult;Affect;Affordable Care Act;African American;African American population;aged;Area;Automobile Driving;Black Populations;Caring;Characteristics;copayment;Country;County;Criminal Justice;Data;Data Sources;Disadvantaged;Disparity;disparity reduction;Drug usage;Eligibility Determination;Enrollment;Equity;ethnic diversity;federal policy;Federally Qualified Health Center;Future;Health;health disparity;health equity;Health Insurance;Health Policy;Healthcare;Heterogeneity;improved;Income;Individual;Institutional Racism;Institutionalization;Insurance;Insurance Coverage;Measures;Medicaid;Mental disorders;Mental Health;Mental Health Services;Mentally Ill Persons;Monitor;National Institute of Mental Health;Neighborhood Health Center;Not Hispanic or Latino;Outcome;Persons;Play;Policies;Population Heterogeneity;Poverty;Privatization;programs;Provider;psychological distress;Qualifying;racial disparity;Racial Equity;racism;Reporting;Research;Running;safety net;severe mental illness;Shapes;sociodemographic variables;Stigmatization;Strategic Planning;Structural Racism;Structure;success;Surveys;System;Time;treatment disparity;Underserved Population;Unemployment;Uninsured;United States Health Resources and Services Administration;uptake;waiver;Work

PROJECT_TITLE: Closing Racial Disparities Through the Affordable Care Act: Medicaid Expansion, Marketplaces, Federally Qualified Community Health Centers

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Patient Safety;Primary Health Care;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative This project analyzes barrier to access to care for Alzheimer’s disease and related dementias for individuals dually eligible for Medicare and Medicaid, whose higher burden and worse management of chronic disease and lower educational level put them at higher risk of dementia. Since many physicians are reluctant to accept Medicaid, because of the greater administrative complexity and lower payment rates, and since patients may lack the health literacy to navigate two distinct coverage systems, dually eligible individuals tend to face substantial obstacles to access. We will disentangle the effect of those different obstacles and investigate how they interact with state- (e.g., number of specialists per capita) and patient-level factors (e.g., distance to facilities, race/ethnicity) to provide guidance for policymakers in all 50 states and the District of Columbia on policy interventions to improve access.

PI_NAMEs: MATTKE, SOEREN  (contact)

PROGRAM_OFFICER_NAME: KELLER, CHANDRA

PROJECT_TERMS: Abnormal coordination;access disparities;Accounting;Address;Adopted;Alzheimer's Disease;Alzheimer's disease related dementia;beneficiary;burden of illness;Cardiovascular Diseases;care systems;Caring;Characteristics;Chronic;Chronic Disease;cognitive testing;Consultations;copayment;Cost Sharing;Counseling;Data;Dementia;dementia risk;Demography;density;Diabetes Mellitus;Diagnosis;Disease;Disparity;Disparity population;District of Columbia;dual eligible;Education;Educational Status;Elderly;Equilibrium;ethnic minority;Ethnic Origin;Event;Face;Failure;falls;Geography;health literacy;Health Services Accessibility;Heterogeneity;High Prevalence;high risk;human old age (65+);Impaired cognition;Impairment;Improve Access;improved;Individual;insight;Institution;Intervention;Low income;Measures;Medicaid;medical specialties;Medicare;Medicare Part B;Medicare/Medicaid;memory care;Modeling;multiple chronic conditions;patient navigation;Patients;payment;Physicians;Policies;Policy Maker;Process;Provider;Race;racial minority;Recommendation;Risk;Risk Factors;risk prediction;Scheme;Services;sex;Smoking;Special needs plan;Specialist;System;Transportation;Variant;Wait Time;wellness visit;Work

PROJECT_TITLE: Policy options to improve access to memory care for disadvantaged individuals who are dually eligible for Medicare and Medicaid


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative/Public Health Relevance The HIV epidemic remains a global public health challenge despite the substantive progress made in disease con- trol measures, including the universal treat and test (UTT) strategy and behavioral interventions to reduce HIV risk behaviors. By designing, validating and disseminating new statistical methods to incorporate social context and heterogeneity investigation in the evaluation of HIV treatment and prevention interventions in order to inform the development of novel, more cost-effective community-based implementation strategies for delivering them, it is expected that this proposal will have a significant impact on public health by contributing to the attainment of global HIV control targets. In particular, the new methods will provide the scientific community with innovative analytical tools to identify more effective combinations of interventions at the individual-level and community-level for reducing HIV transmission and increasing diffusion of preventive behaviors, as well as to identify and inter- vene on more influential individuals who will amplify the dissemination of risk reduction information, preventive behaviors, retention in HIV care, and HIV treatment adherence.

PI_NAMEs: FORASTIERE, LAURA  (contact)

PROGRAM_OFFICER_NAME: SCOTT-SHELDON, LORI ANN JENNIFER

PROJECT_TERMS: Accounting;Acquired Immunodeficiency Syndrome;Adopted;Advanced Development;Affect;Africa South of the Sahara;AIDS prevention;analytical tool;Automobile Driving;Baltimore;Behavior;behavior test;Behavior Therapy;Behavioral;behavioral outcome;Behavioral Sciences;Botswana;Caring;Characteristics;cluster randomized design;Cluster randomized trial;Communicable Diseases;Communities;Computer software;contextual factors;cost effective;design;Development;Diffusion;Discipline;Disease Progression;disorder control;Education;Educational Intervention;effective intervention;Effectiveness;Effectiveness of Interventions;Epidemic;Epidemiology;Evaluation;General Population;Goals;Health;Heterogeneity;high risk population;HIV;HIV Infections;HIV prevention trial;HIV prevention trials network;HIV risk;HIV/AIDS;implementation strategy;improved;Incidence;Individual;Influentials;Injecting drug user;innovation;insight;interest;Intervention;intervention delivery;intervention effect;Investigation;Maryland;Measurement;Measures;men who have sex with men;Methodology;Methods;Mission;Modality;National Institute of Mental Health;Network-based;non-compliance;novel;novel strategies;Outcome;peer;Pennsylvania;Persons;Philadelphia;Phylogenetic Analysis;Population;prevent;Prevention;Prevention trial;Preventive;preventive intervention;Public Health;public health intervention;public health relevance;Randomized;Research;Research Design;Research Personnel;Resources;Risk;Risk Behaviors;Risk Reduction;Sample Size;sex;Site;social;social determinants;Social Environment;social factors;social influence;Social Interaction;software development;South Africa;Specific qualifier value;Statistical Methods;Structural Models;symposium;Testing;Time;tool;transmission process;treatment adherence;treatment as prevention;uptake;user friendly software;user-friendly;validation studies;web site;Work

PROJECT_TITLE: Developing causal inference methods to evaluate and leverage spillover effects through social Interactions for designing improved HIV prevention interventions


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative This is a randomized controlled trial of ÚNETE, “Join Us” in Spanish, an innovative multilevel strategy that combines friendship support networks and targeted messaging from celebrity influencers (actors, singers and sport players) to reduce substance use disparities and the negative effects of social determinants of health in low-income, young adult Latinx.

PI_NAMEs: KANAMORI NISHIMURA, MARIANO JUAN (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: Address;arm;Binding;Broadcast Media;cohesion;Communities;Community Health Aides;community organizations;community partners;COVID-19 pandemic;design;Discrimination;Disparity;Drops;drug abuse prevention;Drug usage;effectiveness evaluation;Face;Florida;food security;Friends;Friendships;Generations;Goals;Hallucinogens;health disparity;Health Promotion;Health Services;Health Services Accessibility;Housing;Immigrant;improved;Individual;innovation;International;Intervention;Latinx;Legal;Low income;Maps;Marijuana;marijuana vaping;multidisciplinary;National Institute of Drug Abuse;news;Nicotine;pandemic disease;Participant;peer support;Population;Poverty;Public Health;Radio;Randomized;Randomized, Controlled Trials;recruit;reduced substance use;Risk;scale up;Services;social health determinants;Spanish;Sports;Stream;Structure;substance use;support network;tailored messaging;Television;Testing;Time;Transportation;web site;Work;young adult

PROJECT_TITLE: ÚNETE: Combining Friendship Support Networks and Targeted Messaging from Celebrity Influencers to Reduce Latinx Substance Use Disparities


NIH_SPENDING_CATS: Aging;Biotechnology;Genetics

ORG_CITY: SAN FRANCISCO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: A fundamentally new approach to the treatment and prevention of age-related diseases is to target the root cause of aging. Under this new paradigm, rejuvenation of aging human tissues and organs represents a promising and exciting direction. Previously we identified 4 transcription factors that can rejuvenate human fibroblast cells aged in vitro through continuous passaging. This project proposes to test the rejuvenating effect of these factors in human fibroblast cells aged inside human body, and in mouse liver. New technologies will be developed to systematically identify combinations of transcription factors for rejuvenation. The proposed research will set a unique stage for discovering combinations of small molecule drugs for rejuvenation therapy.

PI_NAMEs: LI, HAO  (contact);VILLEDA, SAUL A

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: age-related disease;aged;Aging;aging mechanism;aging reversal;artist;Back;Behavioral Assay;Blood;Blood specimen;Brain;cell age;Cell Culture Techniques;Cells;Chromatin Remodeling Factor;Civilization;combinatorial;comparative;computerized tools;CRISPR/Cas technology;Disease;disease model;Dreams;Environment;extend lifespan;EZH2 gene;Fibroblasts;fictional works;Gene Expression Profiling;Genetic Transcription;Grant;hallmarks of aging;high throughput screening;Histology;Human;Human body;human tissue;Imagination;improved;In Vitro;in vivo;Individual;Liver;Methodology;Modeling;Molecular;molecular phenotype;Mus;new technology;novel strategies;old mice;Organ;overexpression;Personal Satisfaction;Pharmaceutical Preparations;Phenotype;Prevention;programs;Rejuvenation;Repression;Research;Sampling;small molecule;STAT3 gene;stem cells;technology intervention;Testing;Tissues;transcription factor;transcriptional reprogramming;transcriptome;Transgenic Mice;translation to humans;United States National Institutes of Health;Youth

PROJECT_TITLE: Cellular and Tissue Rejuvenation through Transcriptional Reprogramming

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Gene Therapy;Genetics;Infectious Diseases;Influenza;Lung;Nanotechnology;Pneumonia and Influenza;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative: The proposed mRNA nanotherapeutics will permit effective ARDS therapy. This mRNA delivery platform presented high generality for encapsulation of various mRNA, and the versatile targeting capability for various cell lines and tissues will contribute to the treatment of vascular diseases, cancer, and vaccine development.

PI_NAMEs: ZHOU, ZHENGJIE  (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: 2019-nCoV;Acute Lung Injury;Acute Respiratory Distress Syndrome;Advisory Committees;Alveolar;alveolar epithelium;Anti-viral Agents;Anti-viral Response;Automobile Driving;Bacteria;Binding;biosafety level 3 facility;Blood Vessels;career development;Cause of Death;Cell Adhesion;Cell Line;Cells;Chicago;clinically relevant;Community Medicine;COVID-19;COVID-19 mortality;COVID-19 patient;Critical Illness;cytokine release syndrome;Data;Development Plans;Disease;Doctor of Philosophy;Edema;Encapsulated;Endothelial Cells;endothelial dysfunction;Endothelium;Engineering;Epithelial Cells;Epithelium;Event;Evolution;Experimental Designs;Functional disorder;Goals;Health;Homeostasis;Human;in vivo;Inflammation;inflammatory lung disease;Influenza;Influenza A Virus, H1N1 Subtype;influenzavirus;inhibitor;innate immune pathways;Innate Immune Response;innovation;Interdisciplinary Study;Interferons;Kruppel-like transcription factors;Lead;Ligase;Liposomes;Lung;Lung Diseases;Lung infections;lung injury;Malignant Neoplasms;Mechanical ventilation;Medicine;Mentors;Messenger RNA;MicroRNAs;Modeling;Molecular;Molecular Profiling;monolayer;Morbidity - disease rate;mortality;mouse model;mRNA delivery;Mus;Mutation;nanomedicine;nanoparticle;nanotherapeutic;novel;oligoadenylate;Pathogenesis;Pathway interactions;Patients;Permeability;Pharmacological Treatment;Play;Positioning Attribute;Postdoctoral Fellow;protein function;Proteins;Publishing;Pulmonary alveolar structure;Pulmonary Edema;Pulmonary Inflammation;rational design;Rattus;Research;research and development;Research Personnel;respiratory virus;response;restoration;Ribonucleases;Role;SARS-CoV-2 infection;Scientist;Small RNA;stem;targeted delivery;Testing;Therapeutic;Therapeutic Effect;therapeutic effectiveness;therapeutic evaluation;Therapeutic Studies;Tidal Volume;Tissues;Training;transcription factor;Universities;vaccine development;Vascular Diseases;Vascular Endothelial Cell;vascular endothelial dysfunction;Vascular Endothelium;ventilation;Viral;viral pandemic;Viral Respiratory Tract Infection;viral RNA;Virus;Virus Diseases;Virus Replication;Water

PROJECT_TITLE: Targeted mRNA therapies treating ARDS

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(MA)]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Diabetes;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human

PHR: People suffering from type 1 diabetes (T1D) could be cured with new stem cell-derived beta cells that restore the glucose homeostatic function lost when endogenous pancreatic beta cells are attacked by the immune system. Beta cells do not function in isolation, however, but rather in the context of a community of other cells and extracellular matrix arranged in a specific 3D structure called the islet. A detailed blueprint of islet structure is not available; therefore, the goal of this proposal is to identify the organizational principles of the islet, paving the way for future work to leverage these principles for engineering more functional islets that ultimately could be moved into clinical trials as a cellular replacement therapy for curing T1D.  1 1U01DK135019 PIs: Sneddon & Gartner 1

PI_NAMEs: GARTNER, ZEV JORDAN;SNEDDON, JULIE BETH (contact)

PROJECT_TERMS: 3-Dimensional;Alpha Cell;analysis pipeline;Area;Basement membrane;Beta Cell;Blood Vessels;Cell Count;Cell Physiology;cell replacement therapy;Cell Shape;cell type;Cells;Classification;Clinical Trials;Communities;Custom;D Cells;Data;design;Diabetes Mellitus;Diabetic mouse;Elements;Endocrine;Endothelium;Engineering;Engraftment;Event;Extracellular Matrix;Future;genome editing;Geometry;Glucagon;Glucose;Goals;Heterogeneity;Human;human embryonic stem cell;Human Engineering;human model;human stem cell-derived;human tissue;Image;imaging Segmentation;Immune;Immune system;Implant;improved;In Vitro;in vivo;Individual;Insulin;Insulin-Dependent Diabetes Mellitus;islet;Islets of Langerhans;Islets of Langerhans Transplantation;learning strategy;Length;Link;Machine Learning;Measures;millimeter;mouse model;Mus;Nerve;Pancreas;Patients;Pericytes;Persons;Probability;Property;reconstitution;Regenerative engineering;Regenerative Medicine;Replacement Therapy;Resolution;response;restoration;sample fixation;Somatostatin;Source;Stains;Statistical Distributions;stem cell model;stem cells;Structure;Structure of beta Cell of islet;submicron;System;Techniques;Testing;Thinness;three dimensional structure;Three-dimensional analysis;Three-Dimensional Imaging;Tissue Engineering;tissue stem cells;transplant model;vascular factor;Work

PROJECT_TITLE: Linking human islet structural heterogeneity to beta cell state


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Heart Disease;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Regular exercise and lifestyle physical activity are critical for quality of life and longevity, and particularly important for a healthy heart. However, exercise anxiety is common and can result in avoidance of exercise, and reliance on false safety behaviors, which leave patients vulnerable to the misperception that it is only safe to exercise under a restrictive set of circumstances. We aim to fill a critical assessment gap by developing and evaluating a novel measure of exercise avoidance and false safety behaviors for use in both research and intervention efforts to help enhance exercise participation in cardiac rehabilitation.

PI_NAMEs: KIBBEY, MINDY MICHELLE (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Acute;Adherence;Aerobic Exercise;age related;Aging;aging related;Alzheimer's Disease;Anxiety;anxiety reduction;Assessment tool;Awareness;Behavior;behavior change;behavior observation;Behavioral;Belief;Benign;bodily sensation;cardiac aging;Cardiac rehabilitation;Cardiovascular Diseases;cardiovascular disorder risk;Cessation of life;Chest Pain;Clinical;Clinical Medicine;clinically relevant;Code;Cognitive;cognitive function;Cognitive Therapy;Data;Dementia;Development;Dimensions;disability;Dyspnea;Enrollment;Esthesia;Event;Exercise;exercise prescription;Exertion;Eye;Face;Factor Analysis;Failure;falls;Focus Groups;frailty;Fright;Generations;healthy aging;Heart;Heart Diseases;heart function;Heart Rate;human old age (65+);improved;Independent Living;Individual;Intervention;Interview;Investigational Therapies;Learning;Life Style;Longevity;Measurement;Measures;Medical;Medicine;Methods;Monitor;mortality;mortality risk;Myocardial Infarction;novel;older adult;participant enrollment;Patient Self-Report;Patients;Physical activity;physical conditioning;Physical Function;Physiologic pulse;Physiological;prevent;Process;programs;Property;prospective;psychologic;Psychometrics;Quality of life;Race;Reaction;Recommendation;Recurrence;Research;Review Literature;Risk;Risk Reduction;Safety;Sampling;Schedule;Shortness of Breath;Speed;Stroke;Structure;Symptoms;targeted treatment;Testing;Therapeutic;therapy design;tool;treadmill;Treatment Efficacy;United States National Institutes of Health;Validity and Reliability;vigorous intensity;Visit;Walking;Work

PROJECT_TITLE: Measurement of Exercise Avoidance and False Safety Behaviors in Older Adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Immunization;Immunotherapy;Infectious Diseases;Transplantation

ORG_CITY: Redwood City

ORG_NAME: TRELLIS BIOSCIENCE, INC.

PHR: Narrative Women who are first infected with HCMV early during pregnancy have ~12% chance that their child will be born with or later develop significant handicaps, primarily deafness but also varying degrees of cognitive and motor function deficits. This population comprises ~120,000 women annually in the US with comparable incidence in Europe and Japan. Reinfection or reactivation of latent infection also contributes to the risk of birth defects. Although harder to detect, and thus less suitable for a clinical trial, the potential benefit of TRL345 likely extends to the entire population of first trimester pregnancies. The economic impact of congenital HCMV, including the costs of medical care and educational expenses, is estimated to be >$3 billion annually (US). HCMV is also the leading viral cause of hospitalization for solid organ and bone marrow transplant patients, impacting close to 50,000 patients annually in the US at a cost of ~$5 billion.

PI_NAMEs: KAUVAR, LAWRENCE MICHAEL (contact)

PROGRAM_OFFICER_NAME: GALIVO, FEORILLO HERRERA

PROJECT_TERMS: Adult;Affinity;Anti-viral Agents;Antibodies;B-Lymphocytes;Binding;Biological Sciences;Bone Marrow Transplantation;cell bank;cell type;Child;Chinese Hamster Ovary Cell;Clinical;clinical development;clinical lot;Clinical Research;clinical trial implementation;Clinical Trials;Cognitive;Communicable Diseases;Complex;Congenital Abnormality;cost;cross reactivity;Cytomegalovirus;Cytomegalovirus Infections;deafness;Delaware;Development;Disease;Documentation;Dose;Drug Controls;Drug Kinetics;economic impact;Education;Epitopes;Ethical Review;Europe;Fetus;First Pregnancy Trimester;first-in-human;Funding;Grant;Health Personnel;healthy volunteer;Hospitalization;Human;Human Cloning;human model;human monoclonal antibodies;Human Pathology;Human Resources;Immunoglobulins;In Vitro;Incidence;Infection;interest;International;Intravenous;Investments;Japan;latent infection;lead candidate;Leadership;Mammals;manufacture;Medical;Medical Care Costs;medical complication;Modeling;Monoclonal Antibodies;Mothers;Motor;National Institute of Allergy and Infectious Disease;neutralizing monoclonal antibodies;operation;Organ;Organ Transplantation;Passive Immunization;Patients;Phase;phase I trial;Phase II Clinical Trials;Placenta;polyclonal human antibody;Population;Positioning Attribute;pre-Investigational New Drug meeting;Pregnancy;prevent;Private Sector;Production;programs;Protocols documentation;Publishing;Quality Control;Rattus;reactivation from latency;Reporting;Risk;Safety;safety assessment;Science;Serotyping;Services;side effect;Site;Small Business Innovation Research Grant;small molecule;Solid;Specificity;stillbirth;Technology;Testing;Therapeutic Agents;Therapeutic antibodies;Therapeutic Monoclonal Antibodies;Tissues;Toxic effect;Toxicology;transmission process;Transplant Recipients;Transplantation;trial planning;U-Series Cooperative Agreements;Viral;Virion;Woman;Work;Writing

PROJECT_TITLE: HCMV Therapeutic Antibody Safety Trial


ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Narrative Accurate assembly and timely departure of CRISPR-Cas9 particles are critical for effective genome editing and future therapeutics. Chromatin remodelers and mismatch repair machinery are important for gene regulation and genome maintenance. High resolution, dynamic studies of CRISPR-Cas9, chromatin remodelers and DNA mismatch repair will help us improve genome editing applications and design therapeutics for diseases that are caused by defects in chromatin remodeling and DNA repair.

PI_NAMEs: HA, TAEKJIP  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Adopted;Area;ATP phosphohydrolase;Binding;Biological Assay;biophysical analysis;biophysical properties;Biophysics;Biotechnology;Cells;Chromatin;chromatin remodeling;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR/Cas technology;Defect;Deposition;design;dimer;Disease;Dissociation;DNA;DNA Damage;DNA Repair;Enzymes;Future;Gene Expression Regulation;Genetic Transcription;Genome;genome editing;Genomics;Guide RNA;helicase;Histones;improved;In Vitro;in vivo;Kinetics;Knowledge;Lesion;Location;Maintenance;Measurement;Measures;Mechanics;Methods;Mismatch Repair;next generation sequencing;novel;Nucleic Acids;Nucleosomes;particle;Pathway interactions;Positioning Attribute;Proteins;Reaction;repaired;Research;Research Personnel;Resolution;response;Ribonucleoproteins;RNA;Sampling;single molecule;Site;Slide;Therapeutic;tool;Yeasts

PROJECT_TITLE: Single molecule and biophysical studies of nucleic acid remodeling

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSURGERY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: The present research is aimed at developing a better understanding of how two brain regions control our behaviors and our behavioral states. Understanding these states has direct relevance to understanding addiction, which is characterized by failure to adequately navigate between different states successfully. Greater understanding of state can point towards improved treatment that gives addicts greater control over their behavior.

PI_NAMEs: HAYDEN, BENJAMIN Y (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TITLE: Neural basis of behavior in freely moving macaques

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Clinical Research;HIV/AIDS;Immunotherapy;Infectious Diseases;Mental Health;Neurosciences

ORG_CITY: BETHESDA

ORG_NAME: HENRY M. JACKSON FDN FOR THE ADV MIL/MED

ORG_STATE: MD

PHR: PROJECT NARRATIVE Antiretroviral therapy does not eliminate HIV reservoirs and HIV continues to persist in tissue compartments, including the brain. Immunotherapies to eliminate these persisting viral reservoirs are being evaluated but targeting HIV reservoirs in the central nervous system (CNS) presents unique challenges. Here, we will assess in two human clinical trials and in the nonhuman primate model of HIV whether an immunomodulatory molecule, the IL-15 super-agonist N-803, can be given safely without CNS toxicity and can boost the antiviral CD8 T cell response in the CNS, reducing HIV reservoir seeding and persistence in the brain. 2

PI_NAMEs: NDHLOVU, LISHOMWA C;OKOYE, AFAMEFUNA ;TRAUTMANN, LYDIE  (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Acute;acute infection;Address;AIDS clinical trial group;Animals;Antigens;antiretroviral therapy;arm;Autopsy;B-Lymphocytes;Bar Codes;Biological Assay;Biological Markers;Blood;blood-brain barrier crossing;Brain;brain tissue;cancer therapy;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Maturation;Cell Physiology;cell type;Cells;Central Nervous System;Cerebrospinal Fluid;Chronic;Clinical assessments;clinical remission;Clinical Trials;Clonality;Complement;Data;design;Disease remission;DNA;Dose;Effector Cell;Epigenetic Process;Evaluation;experimental study;Gene Expression;Generations;Goals;HIV;HIV Infections;Human;Immune;immunological intervention;immunoregulation;Immunotherapy;improved;In Vitro;Infection;Inflammation;interest;Interleukin-15;Interruption;Intervention;Invaded;lymph nodes;Macaca mulatta;Measures;Mediating;Memory;migration;Modeling;multidisciplinary;Natural Killer Cells;Neurocognitive;neuroinflammation;neurotoxicity;nonhuman primate;novel;novel imaging technique;Participant;Pathway interactions;Penetration;Peripheral;Persons;Placebos;Plasma;Population;prevent;Residual state;Resistance;Role;Safety;Sampling;Site;SIV;Specificity;T cell response;Techniques;Testing;Thailand;Therapeutic;therapeutic development;Time;Tissues;tool;Toxic effect;trafficking;Viral;Viral Load result;Viral reservoir

PROJECT_TITLE: Impact of IL-15 immunotherapy on tissue-specific CD8 T cells to reduce the CNS HIV reservoir seeding and persistence


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: BALTIMORE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Understanding how the brain processes sounds is of great importance for the well-being of individuals across society. As harmonics are fundamental elements of speech and music, we investigate how the brain processes these signals by combining advanced neurophysiological and computational methods. Our online stimulus optimization methods hold the potential to be eventually adapted into an automated adaptive diagnosis system for hearing deficits. Findings of the present study will not only advance our understanding of the neural mechanisms underlying hearing and vocal communication with harmonic sounds but also contribute to the development of treatment of hearing loss and impairment.

PI_NAMEs: WANG, XIAOQIN ;ZHANG, KECHEN  (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Animal Vocalization;Area;Artificial Intelligence;Auditory;Auditory area;Brain;Callithrix;Code;combinatorial;Communication;Complex;Computer Models;Computing Methodologies;design;Diagnosis;Effectiveness;Elements;experimental study;Explosion;Frequencies;graduate student;Hearing;hearing impairment;hearing loss treatment;Image;improved;Individual;Methods;Modeling;Monkeys;Music;neural;neural circuit;neuromechanism;Neurons;neurophysiology;Perception;Personal Satisfaction;Population;Postdoctoral Fellow;Primates;Procedures;Process;Research;Research Personnel;response;Response to stimulus physiology;Sensory;Signal Transduction;skills;Societies;sound;spectral energy;Speech;Stimulus;Structure;success;System;therapy development;Training and Education;two-photon;undergraduate student

PROJECT_TITLE: CRCNS: Online optimization for probing high-level auditory representations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-P(50)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: ANN ARBOR

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Cognitive resilience to Alzheimer’s disease (AD) and brain aging is a phenomenon whereby an individual’s cognitive functioning is better than predicted based on chronological age, genetic risk, and/or advanced neuropathology. Understanding the protective factors that improve cognitive resilience requires comprehensive identification of the protein components of unique brain cell types – an analysis that cannot be performed longitudinally in human patients. In this project, we will combine human clinical and molecular data with proteomic data from neurons and immune cells from the hippocampus of mice that are resilient and susceptible to cognitive decline to identify novel proteins and complexes that could ultimately be therapeutically targeted to delay or prevent cognitive symptoms in AD patients.

PI_NAMEs: KACZOROWSKI, CATHERINE COOK (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Age;age difference;Aging;aging brain;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Amino Acids;Amyloid;asymptomatic Alzheimer's disease;Attention;Autopsy;Behavior;behavioral phenotyping;brain cell;brain tissue;candidate identification;cell type;Cells;Chronology;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Cognitive;Cognitive aging;Cognitive deficits;cognitive function;cohort;Communities;Complex;Data;data integration;Data Set;Databases;Disease;Disease Progression;DNA;drug discovery;Electrophysiology (science);Environmental Risk Factor;Exhibits;familial Alzheimer disease;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic approach;Genetic Engineering;Genetic Risk;Genetic Transcription;Genetic Variation;Genomics;Grant;Hand;high dimensionality;high risk;Hippocampus;Human;human data;Human Genetics;Human Genome;human model;human tissue;Immune;Impaired cognition;improved;Individual;Ion Channel;Knowledge;knowledge base;Knowledge Portal;Label;Late Onset Alzheimer Disease;Learning;Link;Mediating;Memory;Memory impairment;Meta-Analysis;Methods;Microglia;Molecular;Molecular Analysis;Molecular Target;mouse model;Mouse Strains;multidimensional data;Mus;Mutation;Neurobehavioral Manifestations;neuroinflammation;neuronal excitability;Neurons;neuropathology;novel;Pathology;Pathway interactions;Patients;Phenotype;Population;Predisposition;prevent;promote resilience;protective factors;Protein Biosynthesis;protein expression;protein protein interaction;Proteins;Proteome;Proteomics;Research;resilience;resilience factor;resilience in aging;Resources;response;RNA;Sampling;segregation;Shiga-Like Toxin I;spatial memory;Synapses;synaptic function;Synaptic plasticity;System;tau Proteins;Technology;Testing;The Jackson Laboratory;therapeutic target;Time;Transcript;transcriptomics;Translating;usability;Variant;Work

PROJECT_TITLE: Cell Type-Specific Proteins that Promote Resilience to Cognitive Aging and Alzheimer's Disease


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Anorexia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Eating Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Nutrition;Obesity

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Anorexia and obesity lie on seemingly opposite ends of the disordered eating spectrum, yet it is well established that these conditions share appetite circuitry that influence the behavioral decision to eat in excess or scarcity. Presently, the genetic mechanism that results in this stark phenotypic difference is not known. The goal of this F99/K00 proposal is to determine if alternative polyadenylation, a rapid activity-dependent RNA processing mechanism, functionally controls information flow from genome to phenome to meter the development of an obese phenotype, as this information has the potential to better inform treatments for disordered appetite.

PI_NAMEs: BRUTMAN, JULIANNA NICOLE (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: Anorexia;Anorexia Nervosa;Appetite Alteration;Appetite Disorder;Appetite Regulation;Appetitive Behavior;behavior influence;Behavioral;behavioral phenotyping;Bioinformatics;Biology;Body Weight;Cancer Cachexia;Cancer Patient;Cannabis sativa plant;career;Cell Culture Techniques;Central Nervous System;Clustered Regularly Interspaced Short Palindromic Repeats;comorbidity;Complex;Computer Models;Cultured Cells;Data;Death Rate;Dependovirus;design;Desire for food;Development;Diabetes Mellitus;diet-induced obesity;Disease;Eating;Eating Disorders;energy balance;Exhibits;experimental study;Exposure to;feeding;Feeding behaviors;Feeding Patterns;Food;gene product;Genes;Genetic;Genome;Genome Mappings;Goals;Health;Heart Diseases;Hyperphagia;Hypothalamic structure;increased appetite;innovation;Institution;Investigation;Knock-out;Knockout Mice;Knowledge;Lead;Learning;Link;Malignant Neoplasms;Mediating;Mental disorders;Messenger RNA;Metabolic;metabolic phenotype;meter;Molds;Molecular;mouse model;mRNA Expression;multiple omics;Mus;Nervous System;Neurobiology;neurogenetics;Neurons;Neurosciences;Neurosciences Research;novel;Nuclear Export;Obesity;obesity development;Operative Surgical Procedures;overweight adults;Pathologic;Pathway interactions;Pattern;Peptide Hydrolases;Pharmaceutical Preparations;Phase;phenome;Phenotype;Polyadenylation;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Process;professor;Protein Array;protein expression;Proteins;Proteomics;Psychopathology;Publishing;Rattus;Regulation;Research;Research Institute;Research Personnel;Research Project Grants;RNA;RNA Processing;RNA Splicing;RNA Stability;Rodent;single cell sequencing;Site;skills;small hairpin RNA;Structure of nucleus infundibularis hypothalami;synaptic function;Synaptic plasticity;targeted treatment;Testing;Tissue Inhibitor of Metalloproteinases;Tissue-Specific Gene Expression;Training;Training Support;Transcript;United States;Universities;Validation;vector;Washington;Weight Gain;Work

PROJECT_TITLE: Alternative polyadenylation as a genetic regulatory mechanism to bridge genome to phenome in the nervous system


ADMINISTERING_IC: TR

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Duchenne/ Becker Muscular Dystrophy;Muscular Dystrophy;Orphan Drug;Pediatric;Precision Medicine;Rare Diseases

ORG_CITY: BINGHAMTON

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

PHR: Narrative Duchenne muscular dystrophy is a progressive neuromuscular disorder caused by loss of dystrophin protein in skeletal muscle and heart. There is an unmet need for serum biomarkers that can be employed to de-risk drug development programs, and further provide objective biomarker outcomes on muscle disease and pathologies in DMD. The proposed research investigates whether drug-related reductions in two inflammatory serum biomarkers, MDC and CD23, predict later clinical motor outcomes in DMD.

PI_NAMEs: HOFFMAN, ERIC P. (contact)

PROGRAM_OFFICER_NAME: CHEN, ALICE

PROJECT_TERMS: Acceleration;Acute;Address;Adrenal Cortex Hormones;Adult;Age;Anti-Inflammatory Agents;arm;Biochemical;Biological Markers;Birth;Blood;bone;boys;carrier testing;CCL22 gene;Childhood;Chronic;Clinical;clinical application;clinical care;clinical efficacy;clinical outcome measures;clinical predictors;Clinical Research;clinical trial readiness;Clinical Trials;Clinical Trials Design;Code;Communities;Data;deflazacort;Development;disability;Disease;Disease Progression;Dose;Double-Blind Method;Double-blind trial;Drug Approval;drug development;Drug Exposure;Drug Monitoring;Drug usage;Duchenne muscular dystrophy;Dystrophin;efficacy outcomes;Event;exon skipping;Exons;Fibrosis;Gene therapy trial;Genes;Growth;Heart;Heart failure;Human Genome;improved;Incidence;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Investigational Therapies;Juvenile Dermatomyositis;Link;macrophage-derived chemokine;male;Membrane;Modeling;Molecular;Monitor;Motor;multiplex assay;Muscle;Muscle Weakness;Mutation;Myopathy;Natural regeneration;Nature;Neuromuscular Diseases;novel;open label;Outcome;Outcome Study;Participant;Pathology;Patient observation;Patients;Pharmaceutical Preparations;pharmacodynamic biomarker;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Pharmacotherapy;Phase;phase III trial;Placebos;predict clinical outcome;predictive marker;Prednisone;primary outcome;Process;Production;Program Development;Proteins;Proteomics;Randomized;randomized trial;Rare Diseases;Regulatory Pathway;Replacement Therapy;Research;Respiratory Failure;response;Risk;Safety;Sampling;School-Age Population;secondary outcome;Serum;Serum Proteins;Skeletal Muscle;Surrogate Markers;Symptoms;Testing;Therapeutic;Tissues;treatment arm;Vasculitis;ventilation;week trial

PROJECT_TITLE: Clinical Trial Readiness for Monitoring Muscle Inflammation in Duchenne Muscular Dystrophy


ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PI_NAMEs: ZHU, YUAN-SHAN  (contact)

PROGRAM_OFFICER_NAME: NAGEL, JOAN DAVIS

PROJECT_TERMS: 3D Print;Academia;Acceleration;Appointment;Biomedical Engineering;career;career development;Caring;Clinical;clinical investigation;Clinical Investigator;Clinical Research;Competence;Complex;Creativeness;Dedications;Development;Education;Educational workshop;Emerging Technologies;Entrepreneurship;Environment;equity, diversity, and inclusion;Faculty;Funding;Future;Government;Grant;hackathon;Health;Healthcare;Industry;Informatics;innovation;Institution;Medicine;Mentors;Mission;Nanotechnology;new technology;next generation;operation;Postdoctoral Fellow;precision medicine;programs;recruit;Research;Research Personnel;Research Proposals;Research Support;residence;Resources;Science;Services;skills;Students;success;Surgeon;Time;Training;Translational Research;Underrepresented Populations;Writing

PROJECT_TITLE: I. Institutional Career Development Core