ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Back Pain;Bioengineering;Chronic Pain;Clinical Research;Complementary and Integrative Health;Neck Pain;Neurosciences;Pain Research;Rehabilitation

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Understanding the highly multifaceted nature of force-based manipulations, particularly for spinal pain, is complicated by the physiologic mechanisms involved, which require the integrative synthesis of fundamental insights from the neuroscience, physics, engineering, physiology, and clinical fields. SPINEWORK is a network of researchers and activities that will be created and evolved to address the need for interdisciplinary research exploring the potential role of force-based manipulations in alleviating spine pain. The network will provide members with the opportunity to identify new collaborators, to learn about other disciplines, to disseminate ideas and information to their colleagues and the larger community, and to foster better interdisciplinary communication.

PI_NAMEs: BAROCAS, VICTOR H;WINKELSTEIN, BETH A (contact)

PROGRAM_OFFICER_NAME: TUTTLE, ALEXANDER H

PROJECT_TERMS: Address;Advisory Committees;Affect;Anatomy;Animal Model;Animals;Area;Award;Biological Markers;Biomechanics;Calendar;chronic pain;Clinic;Clinical;Clinical Sciences;Communication;Communities;Complementary therapies;Computer Models;Confusion;Consultations;Data;Development;diagnostic biomarker;Discipline;diversity and inclusion;Education;Educational Activities;Educational workshop;effective therapy;Engineering;Ensure;Event;Experimental Models;Fertilization;Focus Groups;Fostering;Goals;Grant;Health;health equity;Image;improved;in vitro Model;Infrastructure;innovation;insight;Institution;Interdisciplinary Communication;Interdisciplinary Study;interest;Intervention;Journals;knowledge base;Language;Learning;Low Back Pain;Manuscripts;meetings;member;Mission;Molecular;multidisciplinary;Musculoskeletal;Nature;Neck Pain;neural;Neuromechanics;Neurosciences;non-opioid analgesic;opioid epidemic;organizational structure;Outcome;outreach;Pain;Pain Disorder;Pain management;pain relief;Paper;Pathway interactions;Persons;Pharmaceutical Preparations;Physical therapy;Physics;Physiological;Physiology;Population;Process;productivity loss;programs;Protocols documentation;Publishing;Quality of life;Reporting;Research;Research Personnel;Research Project Grants;Resources;Review Committee;Role;Scientist;Spinal Manipulation;Spine pain;support network;symposium;Terminology;Testing;tool;Vertebral column;virtual;Vocabulary;web site;Work;working group

PROJECT_TITLE: SPINE-WORK: An inclusive research community to study and improve force-based manipulations for spine pain


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE The Texas Developmental Center for AIDS Research (Texas D-CFAR) will facilitate collaborative and multidisciplinary HIV research. The Texas D-CFAR will align with NIH HIV research priorities to foster synergy, promote efficiency, and support coordinated research between its home institutions - Baylor College of Medicine (Houston), University of Texas Health Science Center at Houston, and the Texas Biomedical Research Institute (San Antonio). The Texas D-CFAR will build research capacity to achieve its goal: End HIV and Optimizing Health in Texas.

PI_NAMEs: GIORDANO, THOMAS P (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;AIDS prevention;Area;Award;Basic Science;Biomedical Research;Biometry;Biostatistics Core;California;career;Caring;Censuses;Clinical;Clinical Trials;Collaborations;college;combat;Communication;community advisory board;Community Outreach;coronavirus pandemic;Coupled;Data;Development;Diagnosis;Environment;Epidemic;Event;federal policy;Fostering;Funding;Funding Opportunities;Goals;Health;health determinants;Health Insurance;Health Sciences;Health Services;HIV;HIV diagnosis;HIV Infections;Home;Human Resources;improved;innovation;Institution;Knowledge;Leadership;Learning;Medicaid;Medicine;member;Mentors;Mission;multidisciplinary;Newly Diagnosed;next generation;nonhuman primate;novel coronavirus;Occupational activity of managing finances;Outcome;Persons;Pilot Projects;Policies;Population;prevent;Prevention;Procedures;Process;programs;Public Health;Research;Research Infrastructure;Research Institute;Research Personnel;Research Priority;Research Project Grants;Resource-limited setting;Resources;Risk;Scientist;Services;Strategic Planning;substance use;symposium;synergism;Texas;Training;transmission process;Treatment outcome;United States;United States National Institutes of Health;Universities;US State;Viral;virology;working group


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Basic Science;Biomedical Research;Biostatistics Core;Clinical;Collaborations;college;Communication;community advisory board;community engagement;community organizations;design;Development;Education;Educational workshop;Effectiveness;Ensure;Environment;Evaluation;Event;Faculty;Funding;Funding Opportunities;Future;Goals;Grant;Grant Review;Group Meetings;Health;Health Sciences;Health Services;HIV;Human Resources;improved;Information Dissemination;Infrastructure;Institution;Leadership;live stream;Medical center;Medicine;meetings;member;Mentors;Mission;Monitor;next generation;Occupational activity of managing finances;outreach;Performance;Persons;Policies;Preparation;Procedures;programs;Progress Reports;public health research;Records;recruit;Reporting;Research;Research Activity;research faculty;Research Infrastructure;Research Institute;Research Personnel;Resources;response;Scientist;Series;Services;Site;Strategic Planning;substance use;Surveys;symposium;Texas;timeline;Training;United States National Institutes of Health;Universities;web site;working group

PROJECT_TITLE: Administrative Core A


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Prevention

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Depression cancer Therefore, Narrative is one of the most common psychological comorbidities experienced throughout the continuum and undiagnosed or untreated depression is problematic in oncology settings. the goal of this study is toevaluate a behavioral treatment for diverse cancer patients with elevated depressive symptoms in ambulatory oncology settings.

PI_NAMEs: YANEZ, BETINA  (contact)

PROGRAM_OFFICER_NAME: CHOU, WEN-YING

PROJECT_TERMS: Address;Adherence;Adoption;American Society of Clinical Oncology;Anxiety;Area;Behavior Therapy;Behavioral;behavioral health;Behavioral Model;Cancer Patient;cancer therapy;Caring;Characteristics;Chicago;Clinic;Clinical;Clinical Management;Clinical Oncology;Cognitive;Combined Modality Therapy;comorbidity;computerized;Data;Depression screen;depressive symptoms;Diagnosis;diagnostic criteria;Disease;Distress;Effectiveness;effectiveness evaluation;effectiveness/implementation trial;Electronic Health Record;Emergency department visit;ethnic diversity;Ethnic Origin;Evaluation;evidence base;Evidence based intervention;Evidence based treatment;experience;General Population;Goals;Guidelines;Health;Health Benefit;health information technology;Health Personnel;health related quality of life;health service use;Health system;Home;implementation evaluation;implementation framework;improved;Income;Individual;individualized medicine;Information Systems;Information Technology;instrument;Internet;Intervention;Language;Maintenance;Major Depressive Disorder;Malignant Neoplasms;Measurement;Measures;Mediator;Medicine;Mental Depression;Mental Health;metropolitan;Modeling;mortality;Oncology;operation;Outcome;Outcome Study;Patient Care;Patient Outcomes Assessments;patient portal;Patient Triage;Patients;Population;Prevalence;primary outcome;Process;programs;psychologic;Race;racial diversity;Recommendation;Recording of previous events;recruit;screening;secondary outcome;Self Efficacy;Severities;Severity of illness;sex;Site;Spanish/English;Specificity;standard care;standard of care;suicidal risk;symptomatology;Symptoms;System;Technology;technology intervention;technology platform;Testing;Time;tool;Training;treatment as usual;United States Preventative Services Task Force;Universities;Work

PROJECT_TITLE: Technology Facilitated Behavioral Intervention for Depression among Diverse Patients in Ambulatory Oncology

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: The constant assembly and disassembly of actin filament networks creates a treadmilling system at the front of motile cells that must be coordinated with motor forces in the cell rear to drive normal cell motility, cancer cell metastasis and neuronal growth cone advance. New evidence suggests that the actin filament severing protein, cofilin, can be activated by mechanical stress. This project investigates a role for cofilin activation as a result of actin network shear stress buildup during growth cone responses to local chemotropic cues.

PI_NAMEs: FORSCHER, PAUL  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Actins;Address;Adhesions;Affect;axon growth;Bathing;Behavior;Biological Assay;Calcineurin;cancer cell;Catalysis;Cell Adhesion;cell motility;Cells;cofilin;Cues;Cytoskeleton;density;Development;Eukaryotic Cell;experimental study;Exposure to;F-Actin;G-Protein-Coupled Receptors;Growth;Growth Cones;Integrins;Knowledge;Lead;Literature;Mechanical Stress;Mechanics;Mediating;Microfilaments;Microscopy;Microtubules;Motor;Myosin Type II;Neoplasm Metastasis;neurite growth;Neurites;Neurodegenerative Disorders;neuronal growth;non-muscle myosin;Normal Cell;novel;Pattern;Phospholipase C;Play;Production;Protein Family;Proteins;Regulation;response;Role;Serotonin;shear stress;Signal Pathway;Signal Transduction;spatiotemporal;Stimulus;Stress;Structure;System;Testing;Time;Traction;treadmill;Trefoil Motif;Visualization

PROJECT_TITLE: Mechanical catalysis of calcineurin dependent cofilin activity during chemotropic axon growth: a new role for PKC in coordinating actin dynamics and myosin II contractility

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: ANN ARBOR

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The studies proposed here will define the anti-tumor effect of a new treatment strategy based on targeted elimination of highly tumorigenic cancer stem-like cells combined with tumor debulking with conventional therapy in preclinical models of resistant salivary gland mucoepidermoid carcinoma. The overall significance of the proposed research lies in its potential to lead to discoveries that will ultimately improve the survival and quality of life of patients with salivary gland cancer. This is critical since current benefits of therapy are modest for these patients, and their survival rate remains unacceptably low.

PI_NAMEs: NOR, JACQUES EDUARDO (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Ablation;Acute Myelocytic Leukemia;Address;advanced disease;Affect;aldehyde dehydrogenases;anti-cancer;antitumor effect;Apoptosis;cancer stem cell;carcinogenesis;CD44 gene;Cell Fraction;Cell Line;Cells;Chemoresistance;chemotherapy;Childhood Glioma;Cisplatin;Clinical Trials;clinically relevant;conventional therapy;cytotoxic;Cytotoxic agent;Cytotoxic Chemotherapy;Down-Regulation;Endowment;Excision;Exclusion;Exhibits;exome sequencing;FRAP1 gene;Funding;Genetic;Goals;Head and Neck Squamous Cell Carcinoma;Human;improved;Incidence;inhibitor;Malignant - descriptor;Malignant neoplasm of ovary;Malignant neoplasm of salivary gland;Malignant Neoplasms;MDM2 gene;Mediating;Morbidity - disease rate;mortality;mTOR inhibition;Mucoepidermoid Carcinoma;Mutation;Names;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Oral;Outcome;Outcome Study;overexpression;Pathway interactions;Patients;pharmacologic;Phase I/II Trial;Platinum;Play;Population;Postoperative Period;PRC1 Protein;Pre-Clinical Model;preclinical trial;prevent;Quality of life;Radiation;Radiation therapy;Recurrence;refractory cancer;Relapse;Reporting;Research;Resistance;Role;Safety;safety testing;Salivary Gland Mucoepidermoid Carcinoma;self-renewal;Signal Transduction;small molecule inhibitor;standard care;stem;stem cell self renewal;stem-like cell;stemness;success;Survival Rate;Systemic Therapy;targeted treatment;Testing;Therapeutic;Therapeutic Effect;TP53 gene;translational study;Treatment outcome;treatment response;treatment strategy;tumor;Tumor Debulking;tumor growth;tumor initiation;tumorigenesis;tumorigenic;Up-Regulation;Work;Xenograft Model

PROJECT_TITLE: Salivary gland cancer stem cells

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


PI_NAMEs: RICE, ANDREW P (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Area;Award;Basic Science;biomedical informatics;Biomedical Research;Biostatistics Core;Budgets;career;career development;Clinical;co-infection;Collaborations;college;Communicable Diseases;Communities;comorbidity;COVID-19 pandemic;Development;Discipline of Nursing;Educational workshop;Eligibility Determination;Environment;Faculty;Fostering;Funding;Funding Opportunities;Grant;Group Meetings;Growth;Health;Health Sciences;HIV;Home;Infrastructure;innovation;Institution;interest;Interest Group;Investments;Knowledge;Letters;Link;Medical;Medicine;member;Mentors;Mission;Modeling;Outcome;Outcome Measure;peer;peer coaching;Peer Review;Persons;Pilot Projects;Process;programs;Public Health;Publications;Research;Research Institute;Research Personnel;Research Priority;Research Project Grants;Resources;response;Rest;Review Committee;Series;Services;Students;substance use;symposium;System;Texas;United States National Institutes of Health;Universities;Work;working group;Writing

PROJECT_TITLE: Developmental Core B


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: NARRATIVE In the current study we will establish the mechanistic links between decorin (DCN) expression, diffusion MRI, and anti- VEGF treatment efficacy by first (Aim 1) performing a deep exploration into the association between diffusion MR phenotypes and DCN expression in human GBM using image-guided biopsies and examining DCN protein and gene expression, as well as the relationship with genotypes using whole exome analysis, genetic subtypes using bulk RNA sequencing, cellular states using single-cell RNA sequencing, and blood plasma levels of circulating DCN. Concurrently, we will (Aim 2) establish the causal links between DCN expression, diffusion MRI measurements, and anti-VEGF treatment in GBM by conducting a genetically modified patient-derived orthotopic xenograft (PDX) preclinical trial through editing a series of patient-derived cell lines to silence of overexpress DCN within PDX models using a tetracycline-controlled gene expression system, then perform diffusion MRI and treat with anti-VEGF therapy.

PI_NAMEs: CLOUGHESY, TIMOTHY ;ELLINGSON, BENJAMIN M. (contact);NATHANSON, DAVID A.

PROGRAM_OFFICER_NAME: DARDZINSKI, BERNARD JOSEPH

PROJECT_TERMS: Acceleration;Address;Angiogenesis Inhibitors;Angiogenic Factor;bevacizumab;Biological Markers;Biopsy;Blood;cancer imaging;Cell Line;Characteristics;Chemotherapy and/or radiation;Clinical;Clinical Trials;cohort;Combined Modality Therapy;comparative efficacy;Complex;contrast enhanced;Controlled Clinical Trials;conventional therapy;cost;Data;decorin;Development;Diagnosis;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;DNA;Doxycycline;economic impact;effective therapy;Effectiveness;Epidermal Growth Factor Receptor;exhaust;Exhibits;exome;experience;Extracellular Matrix;Gene Expression;Gene Modified;Genetic;Genetic Transcription;Genotype;Glioblastoma;Glycoproteins;high risk;Human;humanized monoclonal antibodies;Image;Image Guided Biopsy;imaging biomarker;Immunohistochemistry;improved;In Situ Hybridization;Link;Magnetic Resonance Imaging;Measurable;Measurement;Measures;Mesenchymal;Modeling;Nature;neoplastic cell;novel;Operative Surgical Procedures;overexpression;patient derived xenograft model;Patients;Phase;phase II trial;Phenotype;Placebos;Plasma;Play;Pre-Clinical Model;preclinical trial;predictive marker;predictive tools;Prior Therapy;protein expression;PTEN gene;Randomized;Recurrence;Reproducibility;response;response biomarker;risk prediction;risk stratification;Role;Series;single-cell RNA sequencing;standard of care;System;Testing;Tetracyclines;theories;Therapeutic;transcriptome sequencing;Treatment Efficacy;tumor;Tumor Tissue;United States;Vascular Endothelial Growth Factors;Vegf inhibition;Water;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Role of decorin and diffusion MRI in anti-VEGF efficacy for recurrent glioblastoma

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Heart Disease;Pediatric;Pediatric Cardiomyopathy;Prevention;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Hypertrophic cardiomyopathy is the most common genetic cardiac disease and causes a variety of cardiovascular events such as arrhythmias, heart failure, stroke, and sudden cardiac death; however, effective pharmacotherapies to prevent disease manifestation or cardiovascular events are not available. In an ongoing, large multi-center cohort of patients with hypertrophic cardiomyopathy, the investigators will define the role of signaling pathway dysregulation in disease pathogenesis and the development of cardiovascular events by performing proteomics profiling in both plasma and myocardium. This research has the potential to identify potential molecular targets for the prevention of disease manifestation and progression, and to offer novel approaches to specify high-risk subpopulations that benefit most from preventive interventions.

PI_NAMEs: SHIMADA, YUICHI  (contact)

PROGRAM_OFFICER_NAME: REIS, JARED P

PROJECT_TERMS: Affect;Age;Animal Model;Area Under Curve;Arrhythmia;biobank;Cardiac;Cardiomyopathies;Cardiovascular system;Characteristics;circulating biomarkers;Clinical;Clinical Data;Clinical Management;Clinical Markers;clinical phenotype;cohort;Cohort Studies;Cross-Sectional Studies;Data;Development;Devices;Diagnosis;Dilatation - action;Disease;Disease Progression;disorder prevention;drug development;Enrollment;Enzyme-Linked Immunosorbent Assay;Event;evidence base;Exhibits;experience;Family;follow-up;Gene Mutation;Genetic;genetic analysis;Goals;Heart;Heart Atrium;Heart Diseases;Heart failure;high risk;Human;Hydroxymethylglutaryl-CoA reductase;Hypertrophic Cardiomyopathy;Image;implantation;improved;inhibitor;insight;Intervention;Interview;invention;Knowledge;Left;Life Expectancy;MAP Kinase Gene;Matched Case-Control Study;Measures;Mediating;Medical Records;member;Messenger RNA;Meta-Analysis;Molecular;Molecular Biology;molecular drug target;Molecular Target;Myocardium;National Heart, Lung, and Blood Institute;Non-Invasive Detection;novel;novel strategies;Pathogenesis;Pathway interactions;Patients;Persons;Pharmacotherapy;phenotypic data;Plasma;predictive modeling;prevent;preventive intervention;Preventive therapy;prospective;Prospective cohort;Prospective, cohort study;Proteins;Proteomics;Quantitative Reverse Transcriptase PCR;Recording of previous events;Research;Research Personnel;retention rate;Reverse Transcriptase Polymerase Chain Reaction;Risk;risk stratification;Role;Sampling;sex;Signal Pathway;Specific qualifier value;Strategic Planning;Stroke;sudden cardiac death;Symptoms;System;Systems Biology;targeted treatment;Testing;Time;Up-Regulation;Validation;Ventricular;Western Blotting;Work

PROJECT_TITLE: Proteomics profiling in hypertrophic cardiomyopathy and cardiac event prediction

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


NIH_SPENDING_CATS: Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Prevention

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project Narrative Chronic pain is a significant health problem that has led to an epidemic of opioid analgesic overuse and overdose, yet most novel therapeutics have failed to translate to human subjects. To address this problem, it is necessary to fill in a critical gap in knowledge pertaining to how acute pain progresses to chronic pain conditions. We propose that lymphotoxin-beta receptor (LTβR) controls the process of chronic pain development via a conceptually novel peripheral mechanism, providing an effective therapeutic target to prevent the development as well as reverse chronic pain and suffering in multiple pain conditions.

PI_NAMEs: AKOPIAN, ARMEN N (contact);TUMANOV, ALEXEI V

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Acute Pain;Address;Adjuvant Therapy;Afferent Neurons;Age;Agonist;antagonist;Cardiovascular system;Cell Communication;Cell Separation;cell type;Cells;Cessation of life;Chemotherapy-induced peripheral neuropathy;chronic pain;chronic painful condition;combat;Communication;Complex;conditional knockout;Cutaneous;Data;defined contribution;Development;Electrophysiology (science);Epidemic;epidermis cell;Equilibrium;Female;Fiber;Freund's Adjuvant;Genes;Genetic Transcription;Goals;Health;human subject;Hypersensitivity;Immune;Immune response;Immunity;immunopathology;Immunotherapeutic agent;Inflammation;Inflammatory;inflammatory pain;Inflammatory Response;innovation;Ipsilateral;Kidney;Knockout Mice;Knowledge;Ligands;Light;Literature;lymphotoxin beta receptor;Maintenance;male;mechanical allodynia;Mechanics;Mediating;member;Modeling;Mus;nerve damage;Neurologic;Neuropathy;Nociception;novel;novel therapeutics;Opioid Analgesics;opioid epidemic;opioid overdose;opioid overuse;Overdose;Paclitaxel;Pain;pain chronification;Pain Measurement;pain model;Pathway interactions;Patients;Pattern;Peripheral;Peripheral Nervous System Diseases;Persistent pain;Population;prevent;Prevention;Prevention approach;Process;PTPRC gene;Receptor Activation;Receptor Signaling;Research;Resolution;sex;side effect;Signal Transduction;Stratum Basale;Testing;therapeutic target;therapeutically effective;Tissues;trafficking;transcriptome sequencing;transcriptomics;Translating;translational potential;Tumor Necrosis Factor Receptor;Tumor Necrosis Factor-Beta;Up-Regulation;Work

PROJECT_TITLE: Lymphotoxin-Beta Receptor Peripheral Signaling Regulates the Transition to Inflammation and Neuropathy-Induced Chronic Pain

STUDY_SECTION: SPS

STUDY_SECTION_NAME: Somatosensory and Pain Systems Study Section[SPS]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: KIMATA, JASON T. (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Anti-Retroviral Agents;Area;assay development;Award;Basic Science;Biological Assay;Biological Models;Biostatistics Core;CD4 Positive T Lymphocytes;Clinical;Clinical Immunology;Clinical Sciences;Collaborations;comorbidity;cost effective;Custom;Data;Data Analyses;Development;Disease;DNA;Ensure;enzyme linked immunospot assay;Enzyme-Linked Immunosorbent Assay;experience;Experimental Designs;Feasibility Studies;Flow Cytometry;Fostering;Funding;Future;Goals;Growth and Development function;Health;HIV;HIV Infections;HIV/AIDS;Immunologics;Immunology;Immunology procedure;improved;In Situ Hybridization;Inflammation;Institution;instrumentation;Interdisciplinary Study;interest;investigator training;Laboratories;Leadership;Macaca;member;Mentors;microbial;Mission;Modeling;Molecular Virology;multidisciplinary;multiplex assay;new growth;new technology;nonhuman primate;Organoids;Pathogenesis;PET/CT scan;Pharmaceutical Preparations;Pilot Projects;Play;Prevention;programs;protein complex;Protein Databases;Proteomics;Protocols documentation;reactivation from latency;Reagent;Recording of previous events;Records;Reproducibility;Research;Research Activity;Research Personnel;Research Priority;Research Project Grants;Resources;Running;Safety;Services;simian human immunodeficiency virus;single-cell RNA sequencing;SIV;skills;substance use;Surveys;System;Techniques;Technology;Texas;Tissues;Training;Translational Research;United States National Institutes of Health;viral RNA;virology;Virus;Virus Latency;Virus Replication;Vision;Work;working group;X-Ray Computed Tomography

PROJECT_TITLE: Basic Science Core C


ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Cardiovascular disease affects nearly half of all adults in the United States and is responsible for a quarter of all deaths annually, with rates rising. Within the context of three of the largest and richest microbiome profiling studies, this proposal seeks to develop statistical and computational approaches for enabling a more robust and sophisticated understanding of how microbes are related to cardiovascular disease risk factors. This information represents an imperative point of investigation both for possibly improving etiology and for possible development of therapies, particularly as the microbiome is modifiable.

PI_NAMEs: WU, MICHAEL CHIAO-AN (contact)

PROGRAM_OFFICER_NAME: WOLZ, MICHAEL

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Area;bacterial community;Blood Pressure;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cause of Death;Cessation of life;Characteristics;cohort;Cohort Studies;Communities;Computer software;Data;Data Collection;Development;Epidemic;Etiology;Exposure to;high dimensionality;High-Throughput Nucleotide Sequencing;Hypertension;improved;Individual;Intervention;Investigation;Knowledge;Literature;Mediation;Mediator;Methodology;Methods;Microbe;microbial;microbiome;microbiome analysis;microbiome composition;microbiome research;microbiome sequencing;microbiota;Modeling;modifiable risk;Modification;multidimensional data;novel;open source;Phylogeny;Research Personnel;Risk Factors;Role;Sample Size;Scientific Advances and Accomplishments;Statistical Methods;stem;Structure;Taxon;Technology;Testing;therapeutic development;therapy development;tool;United States;user friendly software;Work

PROJECT_TITLE: Statistical Methods for Large Scale Microbiome Studies of Cardiovascular Disease Risk

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Heart Disease;Precision Medicine;Transplantation

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE While treatment with aortic valve replacement (AVR) for aortic stenosis (AS) has historically been reserved for symptomatic severe AS, cardiac remodeling and irreversible injury occur before the onset of symptoms and before AS is "severe" and contribute to death and persistent heart failure symptoms/rehospitalization in up to 40% of patients 1 year after AVR, suggesting that AVR before onset of irreversible changes to the heart is likely to improve post-AVR outcomes. We hypothesize that myocardial remodeling and dysfunction early in the course of AS (mild-moderate; asymptomatic severe) will be accompanied by alterations in the circulating proteome pointing to known and novel pathways contributing to heart failure and providing an early molecular barometer for clinical surveillance and pharmacologic targeting. If successful, the current application will identify a set of circulating proteins linked to early cardiac remodeling phenotypes in AS for potential mechanistic study, pharmacologic targeting, clinical surveillance, and personalized treatment decisions.

PI_NAMEs: FREEDMAN, JANE E;LINDMAN, BRIAN RICHARD (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Acute;Age;aortic valve replacement;Aortic Valve Stenosis;Bioinformatics;Biological;Biological Markers;Cardiac;Cardiac health;Cessation of life;Chronic;Clinical;clinically relevant;cohort;cost;Development;Disadvantaged;Disease;Echocardiography;endophenotype;experience;Fibrosis;Framingham Heart Study;Functional disorder;Heart;Heart failure;heart imaging;hemodynamics;Heterogeneity;high dimensionality;hospital readmission;improved;Individual;Inflammation;Injury;insight;Intervention;Left Ventricular Hypertrophy;Left Ventricular Mass;Link;link protein;Magnetic Resonance;Medical;Molecular;Morbidity - disease rate;mortality;Myocardial;Myocardial dysfunction;Natural Immunity;novel;older adult;Outcome;panacea;Pathway interactions;Patients;personalized approach;personalized medicine;pharmacologic;Phenotype;Populations at Risk;Precision therapeutics;Preparation;pressure;Procedures;Prosthesis;Proteins;Proteome;proteomic signature;Proteomics;Randomized;randomized trial;Recovery;Reproducibility;Residual state;response;Risk;Sampling;Sensitivity and Specificity;sex;statistical learning;Stress;Symptoms;Testing;Tissues;Validation;Ventricular Remodeling

PROJECT_TITLE: Circulating Proteomics to Phenotype the Development and Reversal of Myocardial Remodeling in Aortic Stenosis

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


PI_NAMEs: LAKE, JORDAN E (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;Age Years;Basic Science;biobank;Bioinformatics;Biomedical Research;Biometry;Biostatistics Core;Blood specimen;career;Client;Clinic;Clinical;Clinical Research;Clinical Sciences;cohort;Collaborations;college;Communities;Data;Data Analyses;Data Analytics;Data Collection;data management;Dedications;design;Development;Doctor of Philosophy;Education;Ensure;Epidemic;Evaluation;experience;Faculty;Female;Formulation;Foundations;Funding;Goals;Health;Health Sciences;Health Services;high risk;HIV;HIV prevention trials network;HIV Seronegativity;Home;Human;Human Resources;human tissue;Institution;interest;Jordan;Knowledge;Leadership;Medical center;Medicine;meetings;Mentors;Mentorship;next generation;nonhuman primate;patient population;Patient Recruitments;Persons;Policies;Population;Population Research;Positioning Attribute;pre-exposure prophylaxis;Procedures;Process;recruit;repository;Research;Research Design;Research Institute;Research Personnel;Research Project Grants;Research Support;Resources;Respondent;response;Risk;Sampling;Services;Site;Solid;Specimen;Strategic Planning;success;Surveys;Texas;Tissue Sample;tool development;transgender;Translational Research;United States Department of Veterans Affairs;United States National Institutes of Health;Universities

PROJECT_TITLE: Clinical Core D


ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Overall Project Narrative The mission of the San Diego Center for AIDS Research (SD CFAR) is to drive HIV discoveries and foster cutting-edge research by San Diego investigators to improve the lives of people with HIV and to stop new infections, both locally and globally. The SD CFAR supports basic, clinical, behavioral and translational research programs across our member institutions and fosters the development of emerging investigators, including scientists new to HIV research.

PI_NAMEs: SMITH, DAVID MITCHELL (contact)

PROGRAM_OFFICER_NAME: SCHOONMAKER, ANNALISE ROSA

PROJECT_TERMS: Academy;Acceleration;Acquired Immunodeficiency Syndrome;Address;Advisory Committees;Area;base;Basic Science;Behavioral;Behavioral Research;Breathing;California;Cancer Education Grant Program;career;career development;Caring;Clinical;Clinical Research;Collaborations;Communities;community academic partnership;community engagement;community partners;Development;Educational workshop;Environment;equity, diversity, and inclusion;Evaluation;Feedback;Fostering;Foundations;Funding;Funding Opportunities;Future;Generations;Grant;Grant Review;Growth;health equity;health equity promotion;HIV;Hypersensitivity;Immunology;improved;Infection;innovation;Institution;Interdisciplinary Study;International;international partnership;Journals;Justice;Laboratories;Leadership;low and middle-income countries;meetings;member;Mentored Clinical Scientist Development Program;Mentors;Mission;next generation;NIH Office of AIDS Research;operation;Patients;Performance;Persons;Policies;prevent;Prevention;Productivity;programs;Publications;Reduce health disparities;repository;Research;Research Personnel;Research Priority;Research Support;Resources;Risk;Sampling;Scientist;Services;Strategic Planning;Structure;Surveys;synergism;Training;translational research program;transmission process;underserved community;United States National Institutes of Health;Universities;Work;working group


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Administrative Supplement;Advisory Committees;Area;Awareness;base;Basic Science;Behavioral Sciences;California;Caring;Collaborations;Communication;Communities;community advisory board;community engagement;cost;Development;digital technology;Doctor of Philosophy;Education;Educational workshop;Ensure;Environment;Epidemic;equity, diversity, and inclusion;Evaluation;Event;Fostering;Foundations;Funding;Funding Opportunities;Future;Goals;Grant;health equity;health equity promotion;Healthcare Systems;HIV;Hypersensitivity;Immunology;improved;Infection;Institution;interest;Journals;Justice;Leadership;Linguistics;Medical Research;meetings;member;Mentors;Mexico;Mission;Modeling;multidisciplinary;Needs Assessment;next generation;operation;Persons;prevent;Procedures;programs;Public Health;Recovery;Reporting;Research;Research Personnel;Resources;Scientist;Self-Examination;Services;Social Behavior;Strategic Planning;Structure;symposium;Training;United States National Institutes of Health;Universities;Veterans;web site;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Hematology

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: Project Narrative (relevance of this research to public health): The studies of this application will investigate the mechanism by which components of the natural anticoagulant pathways, thrombin-thrombomodulin and protein C-EPCR complexes, initiate cytoprotective signaling responses to regulate and maintain the integrity of blood vessels. The mis-regulation of these signaling systems can impair vascular function and lead to debilitating thrombotic and inflammatory disorders including heart attack, stroke, and severe sepsis. A better understanding of signaling mechanisms that modulate vascular functions as outlined in this application is essential for discovering new drugs potentially useful for treating ever-increasing inflammatory and thrombotic disorders.

PI_NAMEs: REZAIE, ALIREZA R. (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Actins;activated Protein C;activated protein C receptor;Active Sites;Adenosine Monophosphate;Angiopoietin-2;Anti-Inflammatory Agents;Anticoagulants;Binding;Biological Assay;Blood Vessels;cadherin 5;Catalytic Domain;Cell Proliferation;Cells;Coagulation Process;Complex;Cytoplasmic Tail;Cytoprotection;Cytoskeleton;Data;Disease;Docking;EGF-Like Domain;Endothelial Cells;Endowment;Exclusion;F-Actin;FOXO1A gene;FRAP1 gene;Gene Expression;Genes;Genetic;Human;Immunofluorescence Immunologic;Impairment;Inflammatory;Inflammatory Response;Intercellular Junctions;Knock-out;Knockout Mice;Lectin;Lentivirus;Ligands;Link;Maintenance;Mediating;Membrane;Microfilaments;Monitor;Myocardial Infarction;Neoplasm Metastasis;NF-kappa B;novel therapeutics;Nuclear;overexpression;PAR-1 Receptor;Pathway interactions;Peptide Hydrolases;Permeability;Phenotype;Phosphorylation;Phosphotransferases;polymerization;Polymers;protein activation;Protein C;Proteinase-Activated Receptors;Proteins;Prothrombin;Proto-Oncogene Proteins c-akt;PTEN gene;Public Health;receptor;receptor binding;Recombinants;Regulation;Reproducibility;Research;response;Sampling;Sepsis;Series;Signal Transduction;Signaling Molecule;Site;Specificity;Stroke;Surface;System;Tertiary Protein Structure;Thrombin;Thrombomodulin;Thrombosis;thrombotic;Tissue Sample;Tissues;Transfection;Tumor Suppressor Proteins;Vascular Endothelial Cell;von Willebrand Factor;Western Blotting

PROJECT_TITLE: Protease Activated Receptor and Thrombomodulin Signaling by coagulation proteases

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


PI_NAMEs: SCHMITZ, JOY MARIE (contact)

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;addiction;Affect;AIDS prevention;Alcohols;Area;Basic Science;Biomedical Research;Biostatistics Core;Clinical;Cocaine;cofactor;Collaborations;college;Communities;Complex;Development;Emergency department visit;Ensure;Epidemic;Evaluation;Fostering;Funding;Funding Opportunities;Goals;Grant;Health;Health Sciences;high risk;HIV;Homeless Youth;improved;Individual;Infrastructure;innovation;Institution;interest;International;Lead;Leadership;Link;Marijuana;medical schools;Medicine;member;Mental Health;methamphetamine use;novel;opioid use;Outcome;overdose death;Persons;Pilot Projects;Policies;Procedures;programs;Public Health;Research;Research Institute;Research Personnel;Research Priority;Research Project Grants;Research Support;Resources;Risk Factors;School Nursing;Services;Societies;Substance Addiction;substance use;Substance Use Disorder;substance use treatment;success;Talents;Texas;transmission process;trend;Universities;viral transmission;Work;working group;young adult

PROJECT_TITLE: Substance Use Scientific Working Group


ADMINISTERING_IC: AA

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Excessive alcohol use and alcohol use disorders have an enormous impact on public health, with annual costs in the U.S. estimated to be $249 billion, and the social costs ranging from family disruption to criminal justice are also immense. Alcohol use disorders reflect the interplay of neurobiology, genetics, psychology, and socio-cultural factors. This underscores the critical need for inter-disciplinary research to understand, develop, and test science-based approaches and the necessity of inter-disciplinary training for alcohol researchers in order to develop appropriate interdisciplinary approaches to reducing the harms from alcohol.

PI_NAMEs: HOMISH, GREGORY G. (contact);LEONARD, KENNETH E

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: Alcohols;Etiology;Research Training

PROJECT_TITLE: Research Training on Alcohol Etiology and Treatment


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Digestive Diseases;Immunotherapy;Liver Cancer;Liver Disease;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Therapeutic outcomes following the natural killer (NK) cell-based immunotherapy for hepatocellular carcinoma may be limited if an insufficient number and activity of NK cells reach the targeted tumors. We seek to develop a new image-guided combination liver cancer immunotherapy approach including a) image-guided transcatheter IHA infusion of NKs directly into the blood supply of targeted liver tumor(s) and b) concurrent infusion of nano-size sorafenib-eluting microsphere (nano-SEMs) not only to enhance sorafenib therapeutic efficacy (to avoid severe side effects) but also to strengthen NK antitumor activity.

PI_NAMEs: YAGHMAI, VAHID ;ZHANG, ZHUOLI  (contact)

PROJECT_TERMS: Adoptive Transfer;Apoptosis;BAY 54-9085;Biodistribution;Biological Markers;Cancer Etiology;cancer immunotherapy;Cancer Patient;cancer therapy;cell motility;Cell Proliferation;Cessation of life;Characteristics;Clinical;clinical application;Contrast Media;curative treatments;cytotoxic;cytotoxicity;Detection;detection sensitivity;Diameter;Dose;early detection biomarkers;Excision;FDA approved;ferumoxytol;Goals;Heparin;Homing;image guided;image guided intervention;imaging properties;Immunotherapy;improved;In Vitro;in vivo;indexing;individual patient;Infusion procedures;intrahepatic;kinase inhibitor;Label;Lead;Liver;liver cancer model;Liver neoplasms;Magnetic Resonance Imaging;Magnetism;Malignant neoplasm of liver;Malignant Neoplasms;Maps;Measurement;Methods;Microspheres;migration;Monitor;nanocomplexes;nanosized;Natural Killer Cell Immunotherapy;Natural Killer Cells;neoplastic cell;Operative Surgical Procedures;Oral;Oral Administration;Outcome;Patients;phantom model;Pharmaceutical Preparations;Pilot Projects;Placebos;Portal vein structure;Prediction of Response to Therapy;predictive tools;Predisposition;Primary carcinoma of the liver cells;Protamines;quantitative imaging;Rattus;Reference Standards;Regimen;responders and non-responders;response;Rodent Model;Serum;side effect;success;Systemic Therapy;tablet formulation;Therapeutic;therapy outcome;time interval;tool;trafficking;transcatheter arterial chemoembolization;Transplantation;Treatment Efficacy;treatment response;tumor;tumor specificity;Tumor Tissue;United States;uptake;Vascular blood supply;Visualization

PROJECT_TITLE: Image-guided Interventional Combination Liver Cancer Immunotherapy

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: LEWINSKI, MARY KATHLEEN (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;addiction;Address;Administrative Supplement;Applications Grants;Area;Award;career;career development;clinical investigation;Collaborations;Communities;community research;cost;Data;design;Development;Doctor of Philosophy;Education;Educational workshop;Faculty Recruitment;Feedback;Fostering;Foundations;Funding;Funding Opportunities;Grant;Grant Review;Grant Review Process;HIV;innovation;Institution;Investments;K-Series Research Career Programs;Leadership;leadership development;meetings;member;Mentors;Mentorship;Mission;next generation;outreach;Postdoctoral Fellow;Process;Program Reviews;programs;Public Health;Public Health Schools;Publications;recruit;Reporting;Request for Applications;Research;Research Activity;research faculty;Research Personnel;Research Project Grants;Research Support;Research Training;Review Committee;Role;Science;Scientist;skills;Strategic Planning;substance use;success;Surveys;symposium;Talents;Training;training opportunity;Training Programs;United States National Institutes of Health;Update;web site;Woman

PROJECT_TITLE: Core B: Developmental Core


ADMINISTERING_IC: GM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Prevention

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project Narrative This SEPA project has the potential to increase the diversity of the STEM/health workforce by increasing interest and motivation among high performing students who lack access to opportunities to cultivate their talent. This project will create Hexacago Health Academy 2.0 Game On (HHA 2.0 GO), a theory-based, game-based STEM/health pathway program and The UChicago STEM/Health Pathway Program (UC-SPP), a traditional pathway program. The study will recruit rising 11th graders. The study hypothesis is that High-performing students randomized to HHA 2.0 GO will score higher on a composite measure of self-efficacy, outcome expectations, knowledge, interests, goals, and behaviors regarding STEM/health topics, STEM/health careers, and the college admissions process short term and longitudinally compared to those randomized to UC-SPP or a non- intervention control.

PI_NAMEs: JAGODA, PATRICK  (contact)

PROGRAM_OFFICER_NAME: BECK, LAWRENCE A

PROJECT_TERMS: Academic achievement;Academy;Admission activity;Alcohol dependence;analog;Augmented Reality;Award;Behavior;career;career awareness;Career Choice;Chicago;Cities;Cognitive;college;Communication;Communities;Community Health Education;Comparison arm;Complex;Control Groups;Data;design;digital;Discipline;Drug Addiction;Education;Educational process of instructing;Effectiveness;Elements;eleventh grade;Eligibility Determination;empowerment;ethnic minority;expectation;experience;Exposure to;Focus Groups;Game Based Learning;Goals;group intervention;Health;Health education;health knowledge;Health Personnel;HIV/STD;Instruction;interest;Intervention;Knowledge;Learning;Literature;Measures;Motivation;multidisciplinary;Obesity;Outcome;Pathway interactions;Performance;Personal Satisfaction;Persons;Play;post intervention;Pregnancy;Process;programs;racial minority;Randomized;Randomized, Controlled Trials;recruit;Schools;science education;Self Efficacy;skills;smoking addiction;social;STEM career;STEM field;Stereotyping;Students;success;summer program;Surveys;Talents;Testing;theories;Thinking;trial comparing;Underrepresented Populations;Underrepresented Students;Universities;Violence;Woman;Work;Youth

PROJECT_TITLE: Hexacago Health Academy 2.0: a board game and augmented reality game intervention to promote STEM/health knowledge and career interest

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Substance Misuse

ORG_CITY: COLLEGE STATION

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: PROJECT NARRATIVE  While alcohol use disorder is characterized by compulsive drinking and inflexible behavior, which is likely to involve the brain areas of the thalamus and striatum, little is known about how excessive alcohol intake alters connectivity between these regions, or how such alterations affect behavioral flexibility in alcoholism. The studies in this proposal seek to elucidate the mechanisms involved in thalamic input-mediated changes in striatal cholinergic activity, and investigate how this impacts on reversal learning in flexible behavior. The results obtained will provide important insights into the promotion of behavioral flexibility, and potentially identify new therapeutic strategies to reduce excessive alcohol consumption.

PI_NAMEs: WANG, JUN  (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Acetylcholine;Address;Affect;Alcohol consumption;alcohol exposure;alcohol use disorder;Alcoholism;Animals;Area;Basal Ganglia;Behavior;Behavior Control;Behavioral;Brain;cholinergic;Chronic;Corpus striatum structure;Data;Dopamine;Dopamine D2 Receptor;drinking;drinking behavior;Ethanol;Female;Fiber;flexibility;Goals;Heavy Drinking;Impairment;improved;in vivo;Infection;innovation;insight;Interneurons;Knowledge;male;Measures;Medial;Mediating;Methodology;neglect;Neurons;neurotransmission;new therapeutic target;novel strategies;novel therapeutic intervention;novel therapeutics;Operant Conditioning;optogenetics;Parafascicular Nucleus;Pathway interactions;Photometry;postsynaptic;Prefrontal Cortex;presynaptic;Rabies;Receptor Signaling;Recording of previous events;Regulation;Research;response;Reversal Learning;Rodent;Role;selective expression;Self Stimulation;sensor;Site;Slice;Synapses;synaptic inhibition;System;Testing;Thalamic structure;transmission process;Water

PROJECT_TITLE: Ethanol drinking and the basal ganglia circuitry


ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE The “Cardiovasology” Training Program at Mayo Clinic is an avenue for advanced training of the specialized workforce of physicians/scientists focused on heart health and disease. This proposal expands Program faculty and scope, deepens and broadens its scientific expertise, fosters diversity of mentors and trainees, and integrates new training in emerging technologies and innovations. This Program builds on a four-decades long history of excellence in attracting, mentoring and retaining talented individuals that will form the next generation of science leaders and scholars in this country.

PI_NAMEs: TERZIC, ANDRE  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TITLE: Cardiovasology

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Immunotherapy;Patient Safety;Skin Cancer

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE Patients with melanoma who have a pre-existing autoimmune disease must make complex decisions with their treating physicians about the best treatment options. We propose to provide them with information presented in a user-friendly format to improve treatment decision-making and outcomes.

PI_NAMEs: LOPEZ-OLIVO, MARIA DE LOS ANGELES  (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Adjuvant Therapy;Adverse event;Affect;Age;Autoimmune Diseases;Benefits and Risks;Body System;Cancer Patient;cancer recurrence;cancer risk;cancer therapy;career;Case Series;Cessation of life;Characteristics;checkpoint inhibition;chemotherapy;Chronic;Clinical;Clinical Trials;clinically relevant;Cognitive;comorbidity;Complex;Conflict (Psychology);CTLA4 gene;Data;Decision Making;Development;Diagnosis;Disease;Education;Emotional;Exclusion;experience;Flare;Fright;Goals;Health;Health Personnel;Immune;Immune checkpoint inhibitor;immune-related adverse events;Immunotherapy;improved;Incidence;individual patient;Inflammatory;interest;K-Series Research Career Programs;knowledge translation;Link;Low Literacy Population;Malignant Neoplasms;mathematical ability;Mediating;Medical;Melanoma;Mentorship;Modeling;Monitor;Monoclonal Antibodies;multidisciplinary;No Evidence of Disease;novel;optimal treatments;Outcome;Patient Outcomes Assessments;patient-clinician communication;Patients;Physicians;preference;Principal Investigator;Process;programmed cell death ligand 1;programmed cell death protein 1;Provider;public health relevance;Quality of life;receptor;Recurrence;Research;Research Personnel;Research Proposals;Resectable;Risk;Role;Scientist;shared decision making;skills;Spanish/English;statistics;success;support tools;T cell response;Testing;Therapeutic;Time;Tissues;tool;Toxic effect;Training;Training Programs;Treatment-related toxicity;tumor;Uncertainty;United States Food and Drug Administration;user-friendly

PROJECT_TITLE: Improving decision-making in patients with resectable melanoma and pre-existing autoimmune disease considering immune checkpoint inhibition

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Patient Safety;Prevention;Substance Misuse

PI_NAMEs: KARRIS, MAILE ANN YOUNG (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;AIDS clinical trial group;AIDS Vaccines;Antigens;Basic Science;Behavioral Sciences;Biological;Biological Specimen Banks;Biology;California;Caring;Categories;Clinic;Clinical;Clinical Data;clinical database;clinical investigation;Clinical Investigator;Clinical Research;clinical translation;Clinical Trials Data Monitoring Committees;Collaborations;Communities;community collaboration;community organizations;Consult;Consultations;Data;Databases;Development;Education;Electronic Health Record;falls;Fostering;Goals;Growth;Health;health equity;health equity promotion;HIV;HIV vaccine;human subject protection;Immunology;improved;Industry;Infection;informal learning;Infrastructure;innovation;Institution;Institutional Review Boards;interest;International;International AIDS;International Maternal Pediatric Adolescent AIDS Clinical Trials;Investigation;Leadership;Link;longitudinal dataset;Medicine;member;Mentors;Mentorship;Mission;Monitor;next generation;Participant;Performance;Persons;Populations at Risk;Preparation;prevent;Process;programs;Psychology;Published Comment;recruit;Regulatory Affairs;Research;Research Design;Research Infrastructure;Research Methodology;Research Personnel;Research Priority;Research Training;Risk;Safety;Sampling;Service provision;Services;Social Behavior;socioenvironmental factor;Specimen;Strategic Planning;Structure;symposium;System;Training;Translational Research;translational scientist;Trauma;Viral;Work

PROJECT_TITLE: Core G: Clinical Investigation


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Prevention;Prostate Cancer;Urologic Diseases

PHR: PROJECT NARRATIVE  The purpose of this grant is to develop a method for acquiring a set of MR images in one orientation with modest slice-to-slice overlap and for reconstructing the data to allow improved visualization within the acquired slices. This will allow high quality spatial resolution in all three directions. We will evaluate the method in men suspected of or known to have prostate cancer, and we expect it to provide improved image quality and reduced overall examination time compared to the current practice.

PI_NAMEs: RIEDERER, STEPHEN J (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: 3-Dimensional;Abbreviations;Algorithms;Cancer Detection;Clinical;Collaborations;Data;Development;Diagnosis;Diagnostic;diagnostic accuracy;Diffusion Magnetic Resonance Imaging;diffusion weighted;Early Diagnosis;Encapsulated;Feasibility Studies;Grant;Image;image reconstruction;improved;in vivo;Individual;innovation;Magnetic Resonance Imaging;Malignant - descriptor;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;men;Methodology;Methods;Motion;Normal tissue morphology;Outcome;Pathology;Performance;Peristalsis;Physiologic pulse;Prostate;Qualifying;Radiology Specialty;rapid technique;reconstruction;Relaxation;Reporting;research clinical testing;Resolution;Scanning;Scheme;Screening for Prostate Cancer;Slice;Survival Rate;Techniques;Thick;Thinness;Time;two-dimensional;ultra high resolution;Urology;virtual;Visualization

PROJECT_TITLE: Super Resolution for Improved Multislice Prostate MRI

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Chronic Pain;Genetics;Human Genome;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Chemotherapy-induced peripheral neuropathy is a dose-limiting toxicity of many drugs used in cancer treatment and can adversely affect patient quality of life for years after therapy. The studies proposed in this application will examine the significance of sphingolipid signaling in this neurotoxicity. A detailed understanding of the mechanisms for chemotherapy-induced peripheral neuropathy will support strategies for its prevention and treatment.

PI_NAMEs: KROETZ, DEANNA L (contact)

PROGRAM_OFFICER_NAME: ALTSHULER, RACHEL DINA

PROJECT_TERMS: Address;Affect;Afferent Neurons;axonal degeneration;Cancer Patient;cancer therapy;Cells;chemotherapy;Chemotherapy-induced peripheral neuropathy;Chemotherapy-Oncologic Procedure;Chromatin;chromatin modification;Clinical;Clinical Trials;Coupled;Critical Pathways;Cytoskeleton;Data;Death Rate;Development;Dose Limiting;Drug usage;Event;experimental study;Gene Expression;Gene Expression Regulation;Genes;genetic approach;genetic association;Genetic Polymorphism;Genetic Transcription;Genomic approach;Goals;GTP-Binding Proteins;HDAC4 gene;High Prevalence;Histone Deacetylase;Histone Deacetylase Inhibitor;Human;human induced pluripotent stem cells;improved;induced pluripotent stem cell;inorganic phosphate;Knowledge;Lead;Link;Malignant Neoplasms;Measures;Mediating;Metabolism;Microtubules;Modeling;Molecular;Molecular Conformation;Morphology;multiple sclerosis treatment;Neurites;Neurons;neuroprotection;neurotoxic;neurotoxicity;novel;Paclitaxel;Pathway interactions;patient safety;Patients;Peripheral;Peripheral Nervous System Diseases;Pharmacogenetics;pharmacologic;Pharmacotherapy;Play;prevent;Prevention;Quality of life;Receptor Signaling;receptor-mediated signaling;Regulation;Research;response;rho GTP-Binding Proteins;Risk;Rodent;Rodent Model;Role;Serious Adverse Event;Signal Pathway;Signal Transduction;single cell ATAC-seq;single cell genomics;single-cell RNA sequencing;Sphingolipids;sphingosine 1-phosphate;Sphingosine-1-Phosphate Receptor;Structure;survival outcome;targeted agent;targeted treatment;Testing;Therapeutic;therapeutic effectiveness;Time;Toxic effect;Toxicity due to chemotherapy;Translating;translational study;Validation;Work

PROJECT_TITLE: Sphingolipid Signaling and Chemotherapy-Induced Peripheral Neurotoxicity

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative: This proposal will establish neuropilin-2 as a mediator of aggressive prostate cancer. Detecting neuropilin-2 in human prostate cancer tissues can be a predictor of poor prognosis. Targeting Neuropilin-2 especially its nuclear localization in prostate cancer cell is important for the development of effective therapy.

PI_NAMEs: DATTA, KAUSTUBH  (contact)

PROGRAM_OFFICER_NAME: LIU, ZHIHUI

PROJECT_TERMS: Active Biological Transport;advanced prostate cancer;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Androgens;Binding;Biological Assay;cancer biomarkers;Cancer Patient;Castration;Categories;Cell Nucleus;Cell Physiology;Cell surface;Cells;Classification;Clinical;cohort;Complex;curative treatments;deprivation;Detection;Development;Diffusion;Disease;Disease Progression;Disease Resistance;Disseminated Malignant Neoplasm;effective therapy;Event;Gene Expression;Genes;Genetic Transcription;Goals;Golgi Apparatus;Growth;high risk;Human;Impairment;Indolent;Knowledge;Ligands;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Mediator;Medical center;Membrane;migration;Modality;Modeling;Molecular;molecular marker;Mutation;Nebraska;Neuropilin-2;Neuropilins;Newly Diagnosed;novel;novel therapeutic intervention;Nuclear;Nuclear Envelope;Nuclear Inner Membrane;Nuclear Pore;Nuclear Pore Complex Proteins;nucleocytoplasmic transport;Oncogenes;Operative Surgical Procedures;overexpression;overtreatment;Pathologic;Patients;Pattern;Pore Proteins;Process;Prognosis;Prognostic Factor;Prognostic Marker;Promoter Regions;prostate cancer cell;prostate cancer progression;Prostatic Neoplasms;protein complex;Protein Kinase;Radiation;receptor;receptor function;Receptor Signaling;recruit;Recurrence;Reproducibility;retrograde transport;Retrospective Studies;risk prediction;Role;Route;Signal Transduction;Stains;Sumoylation Pathway;superresolution microscopy;System;Techniques;Testing;Therapeutic Intervention;therapeutically effective;Tissues;transcription factor;treatment strategy;tumor;tumor growth;Universities

PROJECT_TITLE: Nuclear Neuropilin2: a novel molecular mediator for aggressive Prostate Cancer

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: SCHOOLEY, ROBERT TURNER (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Africa South of the Sahara;Area;Asia;Award;base;Behavioral Sciences;Brazil;career;career development;Central Asia;clinical investigation;Collaborations;Communication;Communities;community advisory board;Consultations;cost;Country;design;Development;Doctor of Philosophy;Eastern Europe;empowerment;Ensure;Equipment;Fostering;Funding;Future;global health;Goals;Grant;health equity;HIV;HIV/AIDS;Human;implementation science;improved;India;Inequity;Infection;Infrastructure;innovation;interest;International;Kyrgyzstan;Latin America;Lead;Leadership;Longterm Follow-up;low and middle-income countries;member;Mentors;Mentorship;Mexico;Mission;Mozambique;Office for Human Research Protections;Paper;Peer Review;Persons;Policies;Positioning Attribute;Publications;quality assurance;Research;Research Personnel;Research Priority;Research Project Grants;Research Proposals;Research Support;Scientist;Services;Social Behavior;South Africa;Surveys;Time;Training;Training and Infrastructure;Ukraine;Underrepresented Minority;United States National Institutes of Health;virtual;webinar;Woman;Writing

PROJECT_TITLE: Core I: International


NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: PHYSIOLOGY

ORG_NAME: YALE UNIVERSITY

PHR: The sense for touch is essential for navigation in the environment, manipulation of tools and objects, foraging, detection of physical pain, development of social behaviors. Despite its fundamental importance for physiology, many molecular and physiological aspects of the sense of touch are poorly understood. The goal of this proposal is to unravel the mechanism of touch detection by the specialized end-organs in the skin of vertebrate called Meissner corpuscles. Results from this study will provide general scientific knowledge which will contribute to the development of pharmacological tools to alleviate somatosensory disorders associated with hypersensitivity to touch in humans.

PI_NAMEs: BAGRIANTSEV, SVIATOSLAV  (contact)

PROJECT_TITLE: Mechanism of Meissner corpuscle function

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Immunotherapy;Lung;Lung Cancer;Pancreatic Cancer;Rare Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Our proposal focuses on building advanced animal models of lung and pancreas cancer so that researchers can use these models to make and test new immunotherapies for patients. There are currently no models to test these drugs, so they fail in clinical trials. Our models could help doctors know their therapy will work in patients before the trials, making trials more effective and saving the lives of cancer patients.

PI_NAMEs: JOSHI, NIKHIL  (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Address;Alleles;Animal Model;anti-cancer;anti-tumor immune response;Antibodies;Antigens;Antitumor Response;Benzo(a)pyrene;Cancer Biology;Cancer Model;Cancer Patient;cancer type;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Communication;Cell Line;Cell Transplantation;Cells;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Cytometry;Data;Desmoplastic;Development;Diagnosis;Disease;Disseminated Malignant Neoplasm;drug testing;Engineering;fighting;Generations;Genetically Engineered Mouse;Germ Lines;Growth;Histologic;Histology;Human;Human Biology;human disease;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune response;Immune Tolerance;immunogenic;Immunotherapeutic agent;Immunotherapy;improved;Infection;Inflammation;interest;Investigation;KPC model;Lentivirus;Ligands;Lung Adenocarcinoma;lung development;Lung Neoplasms;lung sarcoma;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Modeling;Mus;Mutagens;Mutate;Mutation;Myelogenous;neoantigens;Neoplasm Metastasis;novel;Organoids;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;patient response;Patients;PD-1/PD-L1;PDL1 pathway;programmed cell death ligand 1;programmed cell death protein 1;Regulatory T-Lymphocyte;Research;Research Personnel;response;Role;Scientist;Shapes;single-cell RNA sequencing;Standardization;STK11 gene;success;T cell infiltration;T cell response;T-Lymphocyte;Testing;therapy resistant;Time;Tobacco;tool;TP53 gene;transcriptomics;translational potential;Translational Research;Transplantation;Treatment Efficacy;treatment response;tumor;tumor growth;tumor immunology;tumor microenvironment;tumor progression;tumor-immune system interactions;Tumor-infiltrating immune cells;Work

PROJECT_TITLE: Developing translationally-relevant genetically engineered mouse models of lung adenocarcinoma for investigations in cancer immunology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-J(55)R]


ORG_CITY: Chicago

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative: Alcohol use disorder (AUD) is a major public health concern worldwide. The whole-genome, as well as mechanistic, approaches to investigate epigenetic and molecular changes in key brain regions underlying behavioral phenotypes of AUD will lead to the identification of novel mechanisms that mediate this disease. The new epigenetic targets can be used to develop drugs for the treatment and prevention of AUD. !

PI_NAMEs: PANDEY, SUBHASH C. (contact)

PROGRAM_OFFICER_NAME: GITIK, MIRI

PROJECT_TERMS: Aberrant DNA Methylation;addiction;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol exposure;alcohol research;alcohol use disorder;Alcohol withdrawal syndrome;Alcoholism;Amygdaloid structure;Anatomy;Animal Model;Animals;Anxiety;Area;ATAC-seq;Autopsy;Behavioral;behavioral phenotyping;Bioinformatics;Brain;brain circuitry;Brain region;Cells;Characteristics;Chemicals;ChIP-seq;Chromatin;chromatin remodeling;Chromatin Structure;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Community Outreach;CRISPR/Cas technology;Data;Data Analyses;demethylation;Dependence;deter alcohol use;Development;Disease;DNA;DNA Methylation;DNA Modification Methylases;DNA Modification Process;drinking;Electrophysiology (science);Emotional;environmental enrichment for laboratory animals;Enzymes;epigenetic marker;Epigenetic Process;epigenome;epitranscriptome;epitranscriptomics;Functional disorder;Funding;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene network;General Population;Genes;Genetic;genetic approach;Genome;genome-wide;Glucocorticoid Receptor;graduate student;High School Student;higher education;Hippocampus;Histone Acetylation;histone acetyltransferase;Histone Deacetylase;histone methyltransferase;histone modification;Histones;Human;hypothalamic-pituitary-adrenal axis;Intake;interdisciplinary approach;Investigation;Knowledge;Lead;Link;Lysine;Maintenance;Mediating;Medical Students;Mental Depression;Methylation;Modification;Molecular;Molecular Biology;molecular phenotype;Molecular Target;Motivation;Mutation;neuroadaptation;Neuroimmune;Neuropeptides;Neurophysiology - biologic function;Neurosciences;neurosteroids;Neurotransmitters;neurotrophic factor;new therapeutic target;next generation;novel;outreach program;Pathogenesis;Pathway Analysis;Pathway interactions;Pattern;Pharmacotherapy;Pilot Projects;Play;Postdoctoral Fellow;pre-clinical research;Prefrontal Cortex;problem drinker;Protein Family;Psychiatry;Public Health;Rattus;Regulation;Research;Research Personnel;Research Project Grants;Resources;Rewards;RNA;Rodent Model;Role;Scientist;Self Administration;Signal Transduction;Signaling Molecule;small hairpin RNA;Small Interfering RNA;Stress;Synapses;System;Testing;Time;Tissue-Specific Gene Expression;training opportunity;transcriptome;transcriptome sequencing;transcriptomics;Translational Research;undergraduate student;Ventral Tegmental Area;viral gene delivery;Visit;whole genome;Withdrawal

PROJECT_TITLE: Center for Alcohol Research in Epigenetics


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Mental Health;Neurosciences;Substance Misuse

PROJECT_TERMS: Abstinence;Administrator;Advisory Committees;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol research;alcohol use disorder;Alcohol withdrawal syndrome;Alcoholism;Alcohols;Amygdaloid structure;Animal Model;Anxiety;Area;Autopsy;Behavioral;Behavioral Mechanisms;behavioral phenotyping;Biological Markers;Brain;brain circuitry;Brain region;brain tissue;Cells;Chemicals;chromatin remodeling;Clinical;Clinical Research;collaborative environment;college;Communication;Communities;Community Outreach;comorbidity;Data;Data Analyses;data repository;demethylation;design;Development;DNA;DNA Methylation;Doctor of Philosophy;doctoral student;drinking;Ensure;Epigenetic Process;epigenome;epigenomics;epitranscriptome;epitranscriptomics;Ethanol;Ethanol dependence;Evaluation;Funding;Future;Gene Expression;Gene Expression Profile;General Population;genome-wide;Genomics;Goals;high standard;High-Throughput Nucleotide Sequencing;Hippocampus;Histone Deacetylase Inhibitor;histone modification;Histones;Human;Individual;Institution;Interdisciplinary Study;interest;International;Leadership;Maintenance;Medical Students;Medicine;meetings;member;Mental Depression;Modeling;Modification;Molecular;molecular targeted therapies;Monitor;Motivation;multidisciplinary;National Institute on Alcohol Abuse and Alcoholism;negative emotional state;neural circuit;Neurosciences;novel;novel therapeutics;Occupational activity of managing finances;outreach program;Peripheral;Pharmaceutical Preparations;Pilot Projects;Play;Post-Traumatic Stress Disorders;Postdoctoral Fellow;Prefrontal Cortex;prevent;Productivity;programs;Progress Reports;Rattus;Research;Research Personnel;Research Project Grants;Resources;RNA;Rodent;Role;Scientist;Services;stem;Testing;Training Programs;transcriptome;transcriptomics;Traumatic Brain Injury;United States National Institutes of Health;Ventral Tegmental Area;Vorinostat;whole genome;Work


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: Nashville

ORG_DEPT: PATHOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

PHR: NARRATIVE Infectious diseases remain the second leading cause of death worldwide, and the rapid rise of antibiotic-resistant bacteria, combined with the emergence of viral diseases, threatens to markedly increase the public health impact of these illnesses. To combat this threat requires new drugs with novel mechanisms of action, a goal that can be achieved by the application of chemical biology to the study of microbiology. This proposal will combine the resources of the Vanderbilt Institute of Chemical Biology (VICB) and the Vanderbilt Institute for Infection, Immunology, and Inflammation (VI4) to train young scientists who will be able to bridge the gap between these disciplines, preparing them to discover the next generation of infectious disease therapeutics.

PI_NAMEs: SKAAR, ERIC P (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TITLE: Chemical Biology of Infectious Diseases (CBID) Training Program

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative This goal of this proposal is to determine how metabolically heterogeneous lung cancer cell sub-populations cooperate to drive invasion and metastasis. We will elucidate the molecular basis and mechanistic underpinnings of how differential metabolism maintains the distinct but cooperative biology that drives collective invasion and conceptually test if co-targeting different metabolic sub-populations limits metastasis.

PI_NAMEs: MARCUS, ADAM I.;SHANMUGAM, MALATHY (MALA)  (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: 3-Dimensional;Address;Area;Automobile Driving;Biology;cancer cell;Cell Proliferation;Cell Respiration;Cells;Chemicals;Citric Acid Cycle;Consumption;Data;Dependence;Environment;forging;Fostering;G6PD gene;Genetic;Genetic Transcription;genomic platform;Genomics;Glucose;Glucose Transporter;glucose uptake;Glycolysis;Goals;Heterogeneity;Hypermethylation;image guided;inorganic phosphate;Invaded;KRASG12D;Lead;Lung Adenocarcinoma;lung cancer cell;Maintenance;Malignant neoplasm of lung;Malignant Neoplasms;Metabolic;Metabolism;Modeling;Molecular;Molecular Analysis;Nature;Neoplasm Metastasis;neoplastic cell;Oxidative Phosphorylation;Pathway interactions;PDH kinase;Pentosephosphate Pathway;pharmacologic;Phenotype;Population;pressure;Proliferating;promoter;Publishing;Pyruvate;pyruvate dehydrogenase;Signal Pathway;SLC2A1 gene;spatiotemporal;targeted agent;targeted treatment;Technology;Testing;Therapeutic;tumor;Tumor Cell Invasion;tumor initiation;tumor progression

PROJECT_TITLE: Implications of metabolic heterogeneity on collective lung cancer cell invasion


PI_NAMEs: GIANELLA WEIBEL, SARA  (contact)

PROJECT_TERMS: Accounting;Acquired Immunodeficiency Syndrome;Basic Science;Behavioral Sciences;Biological;Biological Assay;Biometry;Blinded;Body Fluids;Cellular Immunology;Certification;Charge;clinical investigation;Clinical Sciences;Collaborations;Communication;Communities;computerized data processing;cost;cost effective;cost effectiveness;Data;Data Analyses;data analysis pipeline;Data Reporting;Data Set;design;Development;DNA Sequencing Facility;Doctor of Philosophy;Ensure;Epigenetic Process;Equipment;Funding;Generations;Genomics;Genotype;good laboratory practice;Grant;health equity;HIV;improved;innovation;integration site;International;Investigation;Laboratories;Leadership;Link;Maintenance;member;Mentors;Modeling;Molecular Immunology;Multilingualism;next generation;next generation sequencing;Online Systems;Output;outreach;Pathogenesis;Performance;Price;Procedures;Process;Publications;quality assurance;Quality Control;Reporting;Reproducibility;Research;Research Personnel;Resource Allocation;Safety;Sampling;Science;Services;Site;Social Behavior;Specimen;Standardization;Strategic Planning;Structure;synergism;System;Techniques;Technology;Tissues;tool;Training;Translational Research;transmission process;United States National Institutes of Health;Viral;Viral Load result;virology;Visualization;Work

PROJECT_TITLE: Core K: Translational Virology


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biotechnology;Brain Disorders;Genetics;Human Genome;Neurosciences;Substance Misuse

PI_NAMEs: GRAYSON, DENNIS R (contact)

PROJECT_TERMS: Acetylation;Acute;Address;Affect;Alcohol consumption;alcohol exposure;alcohol research;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;Amygdaloid structure;Antibodies;ATAC-seq;Autopsy;bead chip;Bioinformatics;bioinformatics pipeline;Biological Assay;Brain;Brain region;Catalytic Domain;Chimeric Proteins;ChIP-seq;Chromatin;chromatin remodeling;Chronic;cohort;Complement;Consult;Consultations;Data;data integration;Data Set;Deacetylation;demethylation;Development;Diet;DNA Methylation;drinking behavior;EP300 gene;Epigenetic Process;Ethanol;Female;Functional disorder;Funding;Gender;gene editing technology;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene network;Generations;Genes;Genome;genome-wide;genome-wide analysis;genomic locus;Glucocorticoid Receptor;Goals;Guidelines;Hippocampus;Histone Acetylation;histone methylation;histone modification;Histones;Human;Human Resources;human subject;in vivo;Individual;innovation;insight;large datasets;Link;Liquid substance;Location;male;Measures;Mediating;Messenger RNA;Methylation;mRNA Expression;multiple datasets;New South Wales;novel;NR3C1 gene;p300/CBP-Associated Factor;Pathway Analysis;Phenotype;Play;pre-clinical;Prefrontal Cortex;problem drinker;promoter;Proteins;Protocols documentation;Quality Control;Quantitative Reverse Transcriptase PCR;Rattus;Regulatory Element;Repression;Research;Research Personnel;Research Project Grants;Resources;response;RNA;Rodent;Role;Self Administration;Site;Technology;Testing;tissue resource;Tissues;Training;transcription factor;transcriptome sequencing;Transferase;United States National Institutes of Health;Universities;Ventral Tegmental Area;Withdrawal

PROJECT_TITLE: Epigenetics  Core


ORG_DEPT: PHYSICS

PHR: Program Director (Last, first, middle): Kleinfeld, David Narrative  We propose to disseminate a direct wavefront sensing adaptive optics system for multi-photon microscopy that will enables investigators to probe subcellular dynamics in individual synapses along the full depth of cortex. This is a crucial advance, particularly as layer 5 and 6 cortical output neurons lie deep to the surface so that essentially all current cortical imaging studies are performed on intermediate layer neurons in layers 2/3. Our approach will open up a new subfield of in vivo studies on subcellular determinates of cortical output, as well as in vivo studies on the transformation of layer 4 inputs to layer 5 and 6 outputs.

PI_NAMEs: KLEINFELD, DAVID  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TITLE: Direct wavefront sensing and adaptive optics to enable two-photon imaging axons and spines throughout all of cortex


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Neurosciences;Substance Misuse

PI_NAMEs: GLOVER, ELIZABETH J (contact)

PROJECT_TERMS: Abstinence;Acute;addiction;Address;Affect;Alcohol consumption;alcohol exposure;alcohol research;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;Amygdaloid structure;Animal Model;Anxiety;Attenuated;Automobile Driving;Behavior;Behavioral;Brain;Brain region;brain tissue;Chronic;Cognition;cognitive control;Data;Dependence;Development;Diet;DNA Methylation;drinking;drinking behavior;Epigenetic Process;epigenetic regulation;Ethanol;Experimental Designs;experimental study;Funding;Future;gamma-Aminobutyric Acid;Gene Expression;Genes;genome analysis;Glucocorticoid Receptor;Hippocampus;histone deacetylase 2;Histone Deacetylase Inhibitor;histone modification;Hour;human model;Intake;Link;Liquid substance;maladaptive behavior;Measures;Medial;Mental Depression;Modification;Motivation;negative affect;Negative Reinforcements;neural circuit;neuroadaptation;Neuroimmune;Neurons;neurotransmission;new therapeutic target;Phenotype;Play;pre-clinical;Prefrontal Cortex;Process;Production;Protein Isoforms;Rattus;receptor expression;Recovery;relapse prevention;Research Personnel;Research Project Grants;Resources;Rodent;Role;Self Administration;Signal Transduction;Site;Standardization;Symptoms;synaptic function;Testing;Tissues;Treatment Factor;Validation;Ventral Tegmental Area;Vorinostat;whole genome;willingness;Withdrawal;Withdrawal Symptom;Work

PROJECT_TITLE: Behavioral Core


NIH_SPENDING_CATS: Genetics;Lung;Pulmonary Fibrosis;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative Cell polyploidy is emerging as an inducible and variable feature of tissues, where it is linked to disease physiology across a range of tissue types and organisms. Due to the complex 3-D organization of the lung, alveolar epithelial polyploidy has been unrecognized and its contribution to alveolar homeostasis and repair is unknown. The proposed experiments will address this knowledge gap and provide a mechanistic understanding of alveolar epithelial polyploidy and its contribution to lung fibrosis.

PI_NAMEs: GOTTARDI, CARA J (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: 3-Dimensional;Actins;Acute;Address;AGTR2 gene;Alveolar;alveolar epithelium;alveolar homeostasis;Automobile Driving;biological adaptation to stress;Cell Culture Techniques;Cell Differentiation process;Cell division;Cells;Complex;COVID-19 pneumonia;Credentialing;current pandemic;Cytokinesis;Cytoskeleton;Data;daughter cell;Disease;Distal;Epithelial Cells;epithelial repair;Epithelium;Event;ex vivo imaging;experimental study;F-Actin;Failure;Fibrosis;Future;gain of function;Gases;Genetic Transcription;Homeostasis;Human;human tissue;Hypertrophy;improved;Individual;inhibitor;Injury;injury and repair;Knowledge;Link;loss of function;Lung;lung development;Lung Diseases;lung injury;lung repair;Mitotic;Modeling;Molecular;mouse model;Mus;Organism;Pathway interactions;Patients;Physiology;pneumocyte;Polyploidy;Predisposition;Process;progenitor;programs;Publishing;Pulmonary Fibrosis;regeneration potential;repaired;response;response to injury;Route;Secondary to;Semaphorins;Signal Induction;stem cells;Stress;surfactant;Testing;Tissues;transcriptomics;transdifferentiation;Transitional Cell;Viral Pneumonia

PROJECT_TITLE: Alveolar epithelial stress-induced polyploidization in lung injury and repair

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Neurosciences;Substance Misuse

PROJECT_TERMS: Advisory Committees;alcohol abuse therapy;alcohol comorbidity;Alcohol consumption;alcohol exposure;alcohol research;alcohol use disorder;Alcohol withdrawal syndrome;Alcoholism;Alcohols;Amygdaloid structure;Animal Model;Anxiety;anxiety-like behavior;Area;Attenuated;Autopsy;Basic Science;Behavioral;behavioral phenotyping;Biological Markers;Blood Cells;Brain;Brain Diseases;Brain Injuries;career;Cells;Chronic;Clinical Investigator;Clinical Research;Clinical Trials;Committee Members;comorbidity;Cutaneous T-cell lymphoma;Data;Dependence;DNA Methylation;DNA Modification Process;Electronic Mail;epigenetic marker;Epigenetic Process;epigenome;epigenomics;epitranscriptome;epitranscriptomics;Eukaryotic Initiation Factors;FDA approved;Funding;Funding Mechanisms;Future;Gene Expression Profile;Genes;Histone Deacetylase Inhibitor;histone modification;innovation;Leadership;member;Mental Depression;Mission;Modeling;Modification;Molecular;Motivation;Neurosciences;novel;Office of Administrative Management;operation;Pathogenesis;Pilot Projects;Play;Post-Traumatic Stress Disorders;Prefrontal Cortex;prevent;problem drinker;Procedures;Process;Program Reviews;programs;Prokaryotic Initiation Factor-3;Publications;Reader;Regulation;Research;Research Personnel;Research Project Grants;Risk;RNA;RNA analysis;RNA methylation;RNA-Binding Proteins;Role;single cell genomics;Testing;Tissue-Specific Gene Expression;transcriptome sequencing;transcriptomics;Traumatic Brain Injury;United States National Institutes of Health;Vorinostat;Withdrawal;Work

PROJECT_TITLE: Core - Pilot Program


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Human Genome;Neurosciences;Substance Misuse

PI_NAMEs: BRODIE, MARK S (contact)

PROJECT_TERMS: Abstinence;Acetylation;Affective;Alcohol abuse;Alcohol consumption;alcohol craving;alcohol exposure;alcohol research;alcohol seeking behavior;alcohol use disorder;Alcohol withdrawal syndrome;Amygdaloid structure;Anxiety;Area;ATAC-seq;Autopsy;Behavioral;Biological;Brain;cell type;ChIP-seq;Cholesterol;chromatin immunoprecipitation;Chronic;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Coupled;CRISPR/Cas technology;Data;designer receptors exclusively activated by designer drugs;DNA Methylation;drinking;drinking behavior;effective therapy;Electrophysiology (science);enzyme pathway;Enzymes;EP300 gene;Epigenetic Process;epigenetic regulation;epigenome;Ethanol;Exhibits;experimental study;EZH2 gene;Funding;gamma-Aminobutyric Acid;Gene Cluster;Gene Expression;Gene Expression Regulation;gene network;Genes;Genetic;genetic technology;genome sequencing;Goals;HDAC2 gene;Hippocampus;Histone Acetylation;Histone Deacetylase;Histone Deacetylase Inhibitor;histone methylation;Histone-Lysine N-Methyltransferase;Histones;Human;Induced Neurons;Intervention;Lead;Link;Methods;methyl group;Methylation;Modification;Molecular;Motivation;Neurons;neurosteroids;novel;Nucleus Accumbens;Pathway Analysis;Pathway interactions;pharmacologic;Phenotype;Physiology;Play;pre-clinical;preclinical study;Prefrontal Cortex;prevent;problem drinker;promoter;Proteins;Publishing;Rattus;Recording of previous events;Relapse;Rewards;Role;Sampling;Small Interfering RNA;Substance Withdrawal Syndrome;Symptoms;Synapses;Technology;Testing;transcriptome;transcriptome sequencing;Translating;Ventral Tegmental Area;whole genome;Withdrawal;Work

PROJECT_TITLE: Epigenetic Mechanisms of Positive  Affective State of AUD


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Lung;Tobacco;Tobacco Smoke and Health

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE This project describes a new extracellular entity, the pathogen exosome. In diseases such as COPD this type of exosome drives chronic inflammation, tissue damage, and cell death. A complete understanding of the pathogenic exosome may lead to new diagnostics and therapeutics for chronic inflammatory diseases such as COPD.

PI_NAMEs: BLALOCK, J EDWIN (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: African American;alpha 1-Antitrypsin;Animal Model;Animals;Asian;Biochemistry;Cardiology;Caucasians;Cell Death;Cells;Cellular biology;Chemistry;Chronic;chronic inflammatory disease;Chronic Obstructive Pulmonary Disease;cigarette smoke-induced;Disease;disease phenotype;doctoral student;exosome;exposure to cigarette smoke;extracellular;Extracellular Matrix;Extracellular Matrix Degradation;extracellular vesicles;Faculty;Goals;Grant;Human;Human Biology;human disease;Immune;Inflammation;innovation;Latina;Leukocyte Elastase;Lung;Medical Students;member;Mentors;Mission;Modeling;Molecular Biology;mouse model;multidisciplinary;Mus;National Heart, Lung, and Blood Institute;neutrophil;new therapeutic target;novel;novel diagnostics;novel therapeutics;pathogen;Pathogenicity;Pathway interactions;Patients;Peptide Hydrolases;Phase;Phenotype;Physicians;Physiology;Postdoctoral Fellow;programs;Protease Inhibitor;Protein Kinase Interaction;Receptor-Interacting Protein;Research;Resistance;Resources;Role;Scientist;Smoker;Smoking;Strategic vision;Surface;therapeutic development;Tissues;Training;Translating;United States National Institutes of Health;Work

PROJECT_TITLE: Pathogenic Exosomes in COPD


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

PI_NAMEs: STOCKMAN, JAMILA KINSHASA (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;AIDS prevention;Award;Behavioral;Behavioral Sciences;California;career development;Caring;Collaborations;Communities;community academic partnership;community advisory board;community based research;community collaboration;community engaged approach;community engagement;community organizations;community research;Consult;Dedications;Development;Disparity;Doctor of Philosophy;Drug user;Ensure;Equity;ethnic minority;Faculty;Feedback;Fostering;Funding;gender affirmation;gender minority;health disparity;health equity;Health equity research;HIV;HIV disparities;HIV/AIDS;Human immunodeficiency virus test;innovation;Institution;Interview;Journals;Language;Leadership;marginalized community;marginalized population;Measures;member;Mentors;Mentorship;Methodology;Methods;Mission;next generation;nonbinary;outreach;Participant;participant retention;Patient Recruitments;people of color;Persons;Policy Research;Population;Prevention Research;Process;programs;Qualitative Research;racial minority;recruit;Research;Research Methodology;Research Personnel;research study;retention rate;Science;Services;sex;Sexual and Gender Minorities;social;Social Behavior;Social Sciences;social stigma;Stigmatization;Strategic Planning;structural determinants;Surveys;theories;tool;Training;transgender;treatment research;Underrepresented Minority;underserved community;Underserved Population;Universities;Woman;Work

PROJECT_TITLE: Core M: HESS


PROJECT_TERMS: Acetylation;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol research;alcohol use disorder;Alcohol withdrawal syndrome;Amygdaloid structure;Anatomy;anoctamin 5;Antibodies;Anxiety;anxiety-like behavior;associated symptom;ATAC-seq;Attenuated;attenuation;Autopsy;Behavior;Biological Process;Cell Differentiation process;Cell Nucleus;Chemicals;ChIP-seq;Chromatin;Chromatin Structure;Chronic;chronic alcohol ingestion;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Convulsions;Coupled;CREBBP gene;Data;Data Set;Dendritic Spines;designer receptors exclusively activated by designer drugs;Development;DNA;DNA Damage;DNA Methylation;drinking;drinking behavior;DUSP6 protein;EP300 gene;Epigenetic Process;epigenetic regulation;epigenome;Equilibrium;Ethanol;Ethanol dependence;experimental study;Female;Funding;G9a histone methyltransferase;Gene Expression;Gene Expression Regulation;gene function;gene network;Genes;Genetic;genome-wide;genomic locus;HDAC4 gene;Histone Acetylation;histone acetyltransferase;histone deacetylase 2;Histone Deacetylase Inhibitor;histone modification;Histones;HMGB1 gene;Human;Infusion procedures;Lead;Lysine;Maintenance;male;Measures;Medial;Messenger RNA;Methylation;Modification;Molecular;Molecular Target;negative affect;Neuroimmune;Neurons;next generation sequencing;novel;Pathway Analysis;Pathway interactions;Pharmacotherapy;Play;pre-clinical;preclinical study;premature;prevent;problem drinker;Progress Reports;Proteins;Rattus;Regional Anatomy;Regulation;Relapse;Research;Risk;Risk Factors;Rodent;Role;Self Administration;Small Interfering RNA;Synapses;Synaptic plasticity;Techniques;Testing;Tissue-Specific Gene Expression;transcriptome;transcriptome sequencing;transcriptomics;Translating;translational study;Tremor;Withdrawal;Withdrawal Symptom;Withholding Treatment

PROJECT_TITLE: Epigenetic Mechanisms of Negative Affective State of AUD


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biotechnology;Brain Disorders;Depression;Genetics;Human Genome;Mental Health;Neurosciences;Substance Misuse

PI_NAMEs: LASEK, AMY WOLVEN (contact)

PROJECT_TERMS: 3-Dimensional;Affect;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol research;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;Antibodies;Anxiety;Astrocytes;ATAC-seq;Autopsy;Behavior;Behavioral;Biological Assay;Brain;Brain region;ChIP-seq;Chromatin;chromatin immunoprecipitation;Chronic;chronic alcohol ingestion;Collaborations;Complex;Data;Dependence;Development;Diet;DNA sequencing;Dorsal;Down-Regulation;Epigenetic Process;Ethanol;experimental study;Funding;Gene Expression;gene induction;Gene Proteins;Gene Targeting;Genes;Genetic Transcription;genome-wide analysis;genomic locus;Glial Fibrillary Acidic Protein;Goals;HDAC6 gene;Hippocampus;Histone Deacetylase;Histone Deacetylase Inhibitor;histone demethylase;Histone H3;histone methylation;Human;Immune;Immune response;Immunohistochemistry;inhibitor;knock-down;Lead;Link;Liquid substance;Lysine;Measures;Mediating;Mental Depression;Methods;methyl group;Modeling;Modification;negative affect;neuroadaptation;Neuroimmune;Neuroimmunomodulation;neuroinflammation;new therapeutic target;next generation sequencing;NF-kappa B;novel;Pathway Analysis;pharmacologic;Pharmacotherapy;Phosphorylation;Play;promoter;Rattus;Regulation;Relapse;Research Project Grants;response;RNA;RNA Interference;Role;Self Administration;short hairpin RNA delivery;small hairpin RNA;STAT3 gene;Testing;transcriptome;transcriptome sequencing;translation to humans;Transposase;Tumor Necrosis Factor Receptor;Up-Regulation;Viral;Vorinostat;Withdrawal

PROJECT_TITLE: Epigenetic Mechanisms of Neuroimmune Activation in AUD


PI_NAMEs: GUIDOTTI, ALESSANDRO  (contact)

PROJECT_TERMS: Aberrant DNA Methylation;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol research;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;Animal Model;Antibodies;Anxiety;anxiety-like behavior;ATAC-seq;Australia;Autopsy;bead chip;behavioral phenotyping;Binding;Bioinformatics;Biological Assay;Biological Process;bisulfite;Brain;Chromatin;Chromatin Structure;Chronic;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Cytosine;Data;Data Correlations;Data Set;demethylation;Development;DNA;DNA Methylation;DNA Modification Methylases;DNA Modification Process;Down-Regulation;drinking behavior;Environmental Risk Factor;Enzymes;Epigenetic Process;epigenome;Ethanol;Exons;Female;Functional disorder;Funding;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene network;Genes;Genetic Transcription;genome-wide;genome-wide analysis;Genomics;Glucocorticoid Receptor;Glucocorticoids;Goals;Human;Hypermethylation;Individual;Investigation;Link;Location;Maintenance;male;Measures;Mediating;member;Methods;methyl group;Methylation;Modeling;mRNA Expression;Neurons;New South Wales;new therapeutic target;novel;NR3C1 gene;oxidation;Pathway interactions;Patients;Pattern;Play;Precipitation;preclinical study;Prefrontal Cortex;Process;promoter;Proteins;Quantitative Reverse Transcriptase PCR;Rattus;Reaction;receptor;Recording of previous events;Regulation;Regulatory Element;Research;Role;Sampling;Self Administration;Site;Stress;System;Techniques;Testing;Tetanus Helper Peptide;Thinking;tissue resource;transcription factor;transcriptome;transcriptome sequencing;Translating;translational approach;translocase;Universities;whole genome

PROJECT_TITLE: DNA Methylation/Demethylation Mechanisms in AUD


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Immunotherapy;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: HOUSTON

PHR: NARRATIVE Our recent pilot studies of neoadjuvant immunotherapy in resectable hepatocellular carcinoma (HCC) showed unprecedented pathologic complete responses associated with changes in specific clusters of immune cells, justifying larger trials to test this innovative use of immunotherapy in HCC. The goal of our project is to evaluate the feasibility of this approach and the ability of an established immunotherapy-based regimen for advanced HCC to induce high pathologic response rates when used prior to surgery. We will also examine novel tumor tissue, plasma, and imaging biomarkers that correlate with response to this preoperative therapy.

PI_NAMEs: AMIN, HESHAM M;DUDA, DAN GABRIEL;KASEB, AHMED  (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Adjuvant Therapy;Adverse event;Aftercare;anti-cancer;anti-PD-L1;Area;arm;BAY 54-9085;bevacizumab;Binding;biobank;Biological Markers;biomarker signature;Biopsy;Blood Vessels;cancer cell;Catchment Area;CD8-Positive T-Lymphocytes;Cells;checkpoint receptors;Clinical;clinical biomarkers;Clinical Research;Combined Modality Therapy;cost;cytokine;Data;design;Early Intervention;effector T cell;Excision;General Hospitals;genetic regulatory protein;Geography;Goals;Hepatology;Image;imaging biomarker;Immune;immune checkpoint;Immune response;Immunity;Immunofluorescence Immunologic;Immunotherapy;improved;In complete remission;Incidence;Industry;innovation;Institution;Intervention;Invaded;ipilimumab;Letters;Ligands;liver cancer model;Malignant Neoplasms;Massachusetts;Metabolic;Methodist Church;mortality;MRI Scans;Necrosis;Neoadjuvant Study;Neoadjuvant Therapy;Nivolumab;novel;objective response rate;Operative Surgical Procedures;Outcome;palliative;Pathologic;Pathway interactions;Patients;PD-L1 blockade;peripheral blood;Pharmaceutical Preparations;Phase;phase 2 study;phase 3 study;phase III trial;Pilot Projects;Plasma;Positron-Emission Tomography;Pre-Clinical Model;preclinical study;predicting response;Primary carcinoma of the liver cells;primary endpoint;programmed cell death ligand 1;programmed cell death protein 1;Prospective cohort;Protein Array;Randomized;randomized, clinical trials;Recurrence;Regimen;Regulatory T-Lymphocyte;Resectable;Resected;response;Role;routine practice;Safety;secondary endpoint;single-cell RNA sequencing;Site;Specimen;standard of care;Survival Rate;synergism;T cell infiltration;T-Lymphocyte;targeted treatment;Testing;Time;Tissues;Toxic effect;treatment arm;trial design;tumor;Tumor Immunity;Tumor Tissue;tumor-immune system interactions;Unresectable;Vascular Endothelial Growth Factors;α-Fetoproteins

PROJECT_TITLE: A Phase II and Biomarker Study of Dual VEGF/PD-L1 Blockade in Neoadjuvant Setting in Resectable HCC Patients

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]