NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Services;Mental Health;Mental Illness;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative In response to large numbers of senior center clients who suffer untreated depression and the dearth of geriatric mental health providers, we have simplified Behavioral Activation to be delivered by lay volunteers (“Do More, Feel Better”; DMFB). The focus of Behavioral Activation is to guide clients to reengage in daily pleasant and rewarding activities, and reduce depressive symptoms. If we can show that the lay delivery model has positive impact in comparison to MSW-delivered Behavioral Activation, we will have identified an effective intervention that can be used by a large untapped workforce of older adult volunteers across the nation.

PI_NAMEs: RAUE, PATRICK J (contact)

PROGRAM_OFFICER_NAME: EVANS, JOVIER D

PROJECT_TERMS: Address;Aging;Area;Behavioral;Characteristics;Client;Clinical;Clinical Trials;clinically significant;Communities;community setting;cost;Dementia;Depressed mood;Depression screen;depressive symptoms;Diagnostic;disability;effective intervention;Effectiveness;effectiveness testing;effectiveness trial;Eligibility Determination;ethnic diversity;experience;Funding;Geography;geriatric mental health;Health;Health Personnel;improved;Individual;Infrastructure;Intervention;Label;Light;Mental Depression;Mental disorders;Mental Health;Modeling;National Institute of Mental Health;New York City;non-demented;Nutritional;older adult;Older Population;Outcome;Participant;Population;practice setting;Provider;Psychoses;psychosocial;Randomized;randomized effectiveness trial;Recreation;recruit;Reporting;Resources;response;Rewards;Safety;Sample Size;satisfaction;Service setting;Services;Severities;Site;skills;social;sociodemographic factors;sociodemographics;Supervision;Testing;Time;volunteer;Vulnerable Populations;Work;World Health Organization Disability Assessment Schedule

PROJECT_TITLE: 1/3 Lay-delivered Behavioral Activation in Senior Centers


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Pregnancy;Prevention;Women's Health Research

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: We will perform first systematic test of associations between maternal diagnoses around pregnancy and the risk of ASD in offspring. In order to understand whether the observed associations between maternal diagnoses and ASD arise due to genetic or non-genetic mechanisms, we will then analyze family and molecular genetic data available for this large cohort. Our goal is to identify potential novel risk factors for ASD, close important gaps in the knowledge about the etiology of ASD, and elucidate possible pathways to prevention.

PI_NAMEs: JANECKA, MAGDALENA  (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Accounting;Affect;American;autism spectrum disorder;autistic children;Birth;Brothers;California;Child;Circulation;cohort;comorbidity;Coupled;Data;Data Set;Data Sources;Denmark;design;Development;Diabetes Mellitus;Diagnosis;Disease;disorder risk;Early identification;Ensure;Environmental Risk Factor;Epidemiology;Etiology;experience;Exposure to;Extended Family;Family;family genetics;Family Relationship;Female;Fetus;Genetic;genetic pedigree;Genetic Risk;Goals;Health Status;high risk;indexing;Individual;Infection;innovation;insight;Intellectual functioning disability;International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10);Intervention;Knowledge;Link;Live Birth;male;Maps;Maternal Exposure;Maternal Health;Medical;Medical Records;Mental Depression;Methodology;modifiable risk;Molecular Genetics;Mothers;non-genetic;novel;offspring;Outcome;Output;Parents;Partner in relationship;Pathway interactions;Permeability;Placenta;polygenic risk score;population based;Pregnancy;prenatal;Prevention;Preventive;Process;Public Health;recurrent infection;Registries;response;Risk;Risk Factors;Sampling;sex;Sister;Testing;Time;transmission process;Vertical Disease Transmission;Woman;Work

PROJECT_TITLE: Maternal health in pregnancy and autism risk - genetic and non-genetic mechanisms

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lung;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Respiratory viral infections are an important cause of hospitalization and death in adults, and we are concerned that exposure to outdoor air pollution may reduce the body's ability to fight infection. This epidemiology study will examine the association between short-term exposure to outdoor air pollution concentrations and the immune system response to respiratory viral infection, in a population of adult patients hospitalized with severe respiratory viral infections. By studying this link between air pollution and respiratory viral infection, we can learn how to better counsel our patients to avoid specific pollutants in the short term, so as to protect them against severe respiratory infection, while we contribute to decisions on air quality regulations.

PI_NAMEs: CROFT, DANIEL PATRICK (contact)

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: Acute;Adaptive Immune System;adjudication;Admission activity;Adult;Air;Air Pollutants;Air Pollution;air quality regulation;ambient air pollution;Area;Asthma;base;Biological;Carbon Black;Carbon Monoxide;Cause of Death;Cessation of life;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Chronic pulmonary heart disease;Clinical;Clinical Research;Coughing;Counseling;Crossover Design;Data;Development;Diagnosis;Diagnostic;Diameter;Doctor of Philosophy;Down-Regulation;Dyspnea;Enrollment;Environmental Epidemiology;Epidemiology;epidemiology study;Ethnic Origin;Exposure to;fighting;fine particles;Funding;Future;Gene Expression;Gene Expression Profiling;gene network;Genes;Genetic Transcription;Hospitalization;hospitalization rates;Human Metapneumovirus;Immune;Immune response;Immune Response Genes;Immune system;improved;Infection;Influenza;Inhalation;innate immune pathways;Innate Immune Response;Innate Immune System;Interferon Type II;Interferons;land use;Lead;Leadership;Learning;Link;Lower Respiratory Tract Infection;Measurement;Mentored Patient-Oriented Research Career Development Award;Mentors;meter;Modeling;Modification;Morbidity - disease rate;mortality;Natural Immunity;New York;Nitrogen Dioxide;novel;Nuclear;older adult;Outcome;Ozone;participant enrollment;particle;Particulate;Pathway interactions;Patient Admission;patient population;Patients;Peripheral;peripheral blood;Physicians;Policies;pollutant;Pollution;Population;Predisposition;Productivity;prospective;Prospective Studies;Pulmonary Heart Disease;Race;Research;Research Personnel;residence;Resources;respiratory disorder diagnosis;respiratory health;Respiratory Signs and Symptoms;Respiratory syncytial virus;Respiratory Tract Infections;response;Risk;Risk Factors;risk minimization;RNA;secondary analysis;sex;Site;skills;Source;Structure;study population;Sulfate;Sulfur Dioxide;Testing;Toxin;transcriptome sequencing;transcriptomics;ultrafine particle;Universities;Up-Regulation;Viral Respiratory Tract Infection;virology;Vulnerable Populations;Whole Blood;wood smoke

PROJECT_TITLE: Effect of Air Pollution on the Immune Response to Respiratory Viral Infection in Adults


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Lung;Lung Cancer

ORG_CITY: HOUSTON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: There are few effective therapeutic options for KRAS-mutant lung cancer (KMLC), and there is an urgent need to develop a better understanding of the biological basis of KMLC growth and metastasis. On the basis of the preliminary results presented here, we postulate that KMLC growth and metastasis is driven by a chromosome 1q amplicon containing an actionable Golgi-dedicated kinase (PI4KIIIβ) that promotes secretion of pro- tumorigenic effector proteins. If proven true, these findings would advance our understanding of the mechanisms of KMLC progression and would provide a rationale to advance PI4KIIIβ antagonists into clinical trials for the treatment of KMLC and other chromosome 1q-amplified tumor types.

PI_NAMEs: KURIE, JONATHAN M (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: 1-Phosphatidylinositol 4-Kinase;Acceleration;Address;aerosolized;Alleles;angiogenesis;antagonist;Behavior;behavior influence;Biogenesis;Biological;Blood Vessels;cancer cell;Cancer Model;Cause of Death;CD8-Positive T-Lymphocytes;Cell Physiology;Cell Proliferation;Cell secretion;Cell Survival;Cells;Chromosomes;Clinical;clinical development;Clinical Research;Clinical Treatment;Clinical Trials;Coculture Techniques;CSF3 gene;CXCL1 gene;cytokine;Dedications;Development;Disease;Disseminated Malignant Neoplasm;Docking;Ectopic Expression;effective therapy;Endothelial Cells;Fibroblasts;Fluorescence;Foundations;Genetic Recombination;Golgi Apparatus;GOLPH3 gene;Granulocyte-Macrophage Colony-Stimulating Factor;Growth;IL8 gene;Immunity;improved;Induction of Apoptosis;Inflammation;Inflammatory;inhibitor;inorganic phosphate;insight;Interleukin-6;Invaded;KRAS2 gene;Lentivirus;Link;lung cancer cell;Lung Neoplasms;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Mediating;Membrane;metastatic process;Modeling;Molecular;Mus;mutant;Myeloid Cells;Neoplasm Metastasis;neoplastic cell;novel therapeutic intervention;novel therapeutics;Outcome;phosphatidylinositol 4-phosphate;Phosphoric Monoester Hydrolases;Phosphotransferases;Play;Process;Property;Protein Secretion;Proteins;Regulation;Rest;Role;Site;small hairpin RNA;small molecule;STC2 gene;Structure;Testing;Therapeutic;therapeutically effective;TIMP1 gene;Tissues;trafficking;trans-Golgi Network;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Volume;tumorigenic;Vascular Endothelial Growth Factors;Vesicle;Work

PROJECT_TITLE: Regulation of lung cancer growth and metastasis by an actionable driver of vesicle biogenesis in the Golgi

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: PULLMAN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: NARRATIVE The proposed exploratory studies are an important area of plague research as they have potential to uncover fundamental knowledge about flea processes that can be manipulated by Yersinia pestis to allow it to be transmitted by flea vectors. The findings have potential to be broadly applicable to other flea vector-pathogen interactions. Therefore, discoveries have potential to advance fundamental knowledge applicable to decreasing the public health burden of plague and other flea-borne diseases like rickettsioses and bartonelloses.

PI_NAMEs: VADYVALOO, VIVEKA  (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN

PROJECT_TERMS: Acetylcysteine;Anatomy;Antioxidants;Area;Arthropods;Back;Bacteria;Biological Process;Biology;Blood;blood product;Chloroquine;Color;Communicable Diseases;comparative;defense response;Dermis;Development;Digestion;Disease;Disease Management;Drug Metabolic Detoxication;Environmental Impact;Event;Exhibits;feeding;flea-borne;Fleas;follow-up;Gene Expression Profiling;Genes;Goals;Gram-Negative Bacteria;Health;Heme;hemozoin;Human;human disease;Immune;Immune response;In Situ Hybridization;Infection;Insecticide Resistance;Insecticides;Kinetics;Knowledge;Link;Lipids;Mediating;Microbial Biofilms;Mission;Mus;mutant;novel;Oxidases;Oxygenases;Parasites;pathogen;pathogenic bacteria;Pathology;Physiology;Plague;polymerization;Polymers;Primitive foregut structure;Process;Production;Proliferating;Proventriculus;Public Health;Rattus;Reactive Oxygen Species;Research;response;Rickettsia Infections;Rodent;Role;Site;Source;success;Testing;Toxic effect;Toxin;Transcript;transcriptomics;transmission process;United States National Institutes of Health;vector;Vector-transmitted infectious disease;Yersinia;Yersinia pestis

PROJECT_TITLE: Emerging understanding of the rat flea response to Yersinia pestis infection

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


NIH_SPENDING_CATS: Cancer;Genetics;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: PORTLAND

ORG_DEPT: PHYSIOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE The proposed research is to develop a targeted therapy for clear cell sarcoma of soft tissue.

PI_NAMEs: LI, BINGBING  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: activating transcription factor 1;Adjuvant Therapy;Adolescent and Young Adult;Amputation;aponeurosis;Automobile Driving;bcr-abl Fusion Proteins;Biochemical;Biological;Biological Assay;cancer cell;Cells;chemical genetics;chemotherapy;Chimeric Proteins;Chromosomal translocation;Chronic Myeloid Leukemia;Clear Cell Sarcoma;Combined Modality Therapy;Complex;Cyclic AMP-Responsive DNA-Binding Protein;Development;Diagnostic;Disease;disorder control;Ewings sarcoma;Excision;Exhibits;Genes;genetic approach;Genetic Transcription;Genomics;Goals;In Vitro;in vitro activity;in vivo;inhibitor;innovation;Lower Extremity;Mediating;member;Molecular;new therapeutic target;novel drug combination;novel therapeutics;Oncogenes;Operative Surgical Procedures;Patients;Pharmaceutical Chemistry;Phosphorylation;preclinical study;protein arginine methyltransferase 2;Protein Family;Protein-Arginine N-Methyltransferase;Rare Diseases;Research;RNA-Binding Protein EWS;Role;Safety;small molecule;small molecule inhibitor;Soft tissue sarcoma;Survival Rate;targeted treatment;Tendon structure;Testing;therapeutic target;Tissue Model;Tissue Survival;Transcription Coactivator;transcription factor;Transcriptional Activation;treatment strategy;tumor

PROJECT_TITLE: Targeting EWS-ATF1 Fusion in Clear Cell Sarcoma of Soft Tissue

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Hypertension;Kidney Disease;Lung;Neurodegenerative;Neurosciences;Postural Orthostatic Tachycardia Syndrome;Sleep Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE PUBLIC HEALTH RELEVANCE STATEMENT Autonomic failure patients (due to Parkinson disease, pure autonomic failure and multiple system atrophy) have nocturnal supine hypertension which is difficult to treat without worsening their orthostatic hypotension. We propose a novel therapeutic approach of using continuous positive airway pressure (CPAP) to control nocturnal hypertension, reduce unary volume loss and improve daytime orthostatic hypotension. We believe our results will provide the mechanistic insight to develop a simple but elegant and highly innovative approach to treat nocturnal hypertension in these patients.

PI_NAMEs: BIAGGIONI, ITALO  (contact);OKAMOTO, LUIS ENRIQUE

PROGRAM_OFFICER_NAME: SCHUM, PAULA

PROJECT_TERMS: Abdomen;Acute;arterial stiffness;autonomic reflex;Blood Pressure;Buffers;Cardiac Output;Cardiovascular system;Chest;Clinical;clinically significant;comorbidity;Continuous Positive Airway Pressure;disability;Disabling;Disabling condition;Diuresis;effective therapy;Elderly;Electric Capacitance;Exclusion;Failure;fall risk;falls;Fright;Goals;Head;hemodynamics;Hormones;Hypertension;Impairment;improved;indexing;innovation;insight;Knowledge;Masks;mortality;Multiple System Atrophy;Natriuresis;Nerve Degeneration;neurogenic orthostatic hypotension;Nocturia;Nocturnal Hypertension;novel;novel strategies;novel therapeutic intervention;Obstructive Sleep Apnea;Organ;Orthostatic Hypotension;Outcome;Output;Parkinson Disease;patient population;Patients;Positioning Attribute;positive airway pressure;pressure;public health relevance;Pure Autonomic Failures;Quality of life;Regulation;Risk;Risk Factors;Sleep;Sleep disturbances;Splanchnic Circulation;Stroke Volume;Supination;Testing;Trimethaphan;urinary;Venous;Weight

PROJECT_TITLE: Hemodynamic Effects of Positive Airway Pressure to Treat Supine Hypertension and Improve Neurogenic Orthostatic Hypotension

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: ATLANTA

ORG_DEPT: CHEMISTRY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Public Health Relevance The proposal aims to develop tools to understand how mechanical forces influence the functions of the adaptive immune system, which rids our bodies of pathogens and cancer. If successful, this project will lead to improved methods of engineering the immune system to fight cancer and to treat autoimmune disease.

PI_NAMEs: SALAITA, KHALID S. (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Adaptive Immune System;Address;Adult;Affinity;Amino Acids;antigen-specific T cells;Antigens;Area;Autoimmune Diseases;Beds;Binding;Binding Sites;Biological Assay;Biomechanics;Biotin;cancer cell;cancer immunotherapy;Cancerous;Cell surface;Cells;Cellular biology;chimeric antigen receptor;chimeric antigen receptor T cells;Clone Cells;Complex;Data;design;DNA;DNA Probes;Eligibility Determination;engineered T cells;Enzymes;Event;experience;experimental study;FDA approved;fighting;Flow Cytometry;Genotype;Geometry;Goals;high throughput screening;Human;Human body;Immobilization;Immune;Immune response;immunoengineering;Immunology;improved;innovation;interest;Label;Ligands;Ligase;Link;Major Histocompatibility Complex;Malignant Neoplasms;Maps;Measures;mechanical force;Mechanics;mechanotransduction;meter;Methods;Modeling;Molecular;molecular mechanics;mutant;Mutate;nanometer;neoantigens;Nucleic Acid Probes;nucleic acid stability;Nucleic Acids;Oligonucleotides;Outcome;Ovalbumin;particle;pathogen;Pathway interactions;Peptide Fragments;Peptide Library;Peptides;Peroxidases;Phenotype;phenoxy radical;Population;Process;protein aminoacid sequence;protein complex;protein protein interaction;Proteins;Proteomics;public health relevance;Radial;Reaction;Reagent;receptor;Receptor Activation;receptor binding;Receptor Signaling;recruit;Research;Scanning;screening;Screening procedure;Signal Transduction;single molecule;small molecule;Specificity;Spectrum Analysis;Surface;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Techniques;Technology;Testing;tool;Transcend;transmission process;virtual;Virus;Work

PROJECT_TITLE: Mechano-ID for tagging immune cells


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative: Septins undergo dynamic high-order assembly and remodeling to execute a scaffolding and/or diffusion-barrier role in diverse functions including cytokinesis, cell morphogenesis, and cell migration. Mutations or overexpression of septins are associated with cancer, neurodegenerative diseases, and infertility. Thus, our proposed study on the mechanisms of septin high-order assembly and architectural remodeling is fundamentally important not only for basic research but also for public health.

PI_NAMEs: BI, ERFEI  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Actomyosin;Alzheimer's Disease;Anaphase;anillin;Architecture;Bacterial Infections;Basic Science;Binding Proteins;Biological Models;Cell membrane;cell motility;Cell Physiology;Cells;Cellular Structures;cilium biogenesis;Complex;constriction;Cytokinesis;Cytoskeleton;Data;Daughter;Defect;Dendritic Spines;Diffusion;Electron Microscopy;Environment;Excision;Filament;Genes;hereditary neuropathy;Higher Order Chromatin Structure;Human;imaging modality;Imaging technology;Infertility;insight;light microscopy;Malignant Neoplasms;Mammalian Cell;Mitotic;Modeling;molecular assembly/self assembly;Morphogenesis;Mothers;Mutation;Myosin Type II;Neck;Neurodegenerative Disorders;Organism;overexpression;Parkinson Disease;Phosphorylation;Phosphotransferases;Platinum;Play;Process;Protein Dephosphorylation;Protein Kinase;Protein phosphatase;Proteins;Public Health;Regulation;Research;Resolution;Rod;Role;Saccharomyces cerevisiae;Saccharomycetales;scaffold;Shapes;Site;Spermiogenesis;STK11 gene;Structure;System;Testing;tool;tumorigenesis;ultra high resolution;Visualization;yeast genetics;Yeasts

PROJECT_TITLE: Analysis of Septin Structure and Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Z(02)M]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Narrative The mechanisms by which global regulatory proteins operate on their RNA targets are complex and are still largely not understood; understanding these mechanisms is crucial for preventing or alleviating bacterial infections and antibiotic resistance. The overarching goal of the proposed work is to characterize in vivo the molecular features that underlie novel CsrA-target interactions that we have recently uncovered as well as to decipher the biological relevance of these interactions; the CsrA protein is part of the Csr (carbon storage regulator) system, a global regulatory network known to impact virulence factors, secretion systems, and other important genes for rapid host adaptation in a number of pathogens. We expect these studies to further expand our knowledge of the diversity of post-transcriptional regulation approaches that global regulators can exert in bacteria.

PI_NAMEs: CONTRERAS, LYDIA MARIA (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: 5' Untranslated Regions;Antibiotic Resistance;Bacteria;Bacterial Infections;Binding;Binding Sites;Biological;Biological Assay;Carbon;Cells;cofactor;Collaborations;Complex;EMSA;Escherichia coli;flexibility;Genes;genetic regulatory protein;Goals;head involution defective protein;Homologous Gene;In Vitro;in vivo;innovation;Knowledge;Lead;Literature;Maps;Messenger RNA;Methods;Modeling;Molecular;novel;Outcome;pathogen;Pathway interactions;Pattern;Post-Transcriptional Regulation;posttranscriptional;prevent;Proteins;Pseudomonas aeruginosa;Regulation;Reporting;Repression;Resistance to infection;RNA;RNA Binding;RNA-Binding Proteins;Scheme;Stress;System;Testing;Text;therapeutic target;time use;tool;Virulence Factors;Work

PROJECT_TITLE: Novel mechanisms of posttranscriptional regulation by CsrA

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Comparative Effectiveness Research;Cost Effectiveness Research;Digestive Diseases;Dissemination and Implementation Research;Health Services;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Telehealth;Women's Health Research

ORG_CITY: MARBLEHEAD

ORG_NAME: IMPLENOMICS LLCS

ORG_STATE: MA

PHR: PROJECT NARRATIVE A large proportion of cancers in India are detected at a late stage, which results in high mortality. The goal of this study is to develop a low-cost mobile health platform that will educate individuals and providers via apps using their own mobile devices and connect them with screening support staff at tertiary medical colleges who will provide coordination and navigation support. This approach will address current patient, provider, and health system gaps and offer an interconnected infrastructure to deliver organized population-based screening to reduce the burden from cancer in India and other resource-constrained settings.

PI_NAMEs: SUBRAMANIAN, SUJHA  (contact)

PROGRAM_OFFICER_NAME: PEARLMAN, PAUL C

PROJECT_TERMS: Address;Awareness;Breast Cancer Detection;Cancer Burden;cancer care;Cancer Detection;cancer education;cancer risk;Caring;Cervical Cancer Screening;Cluster randomized trial;Colorectal Cancer;colorectal cancer screening;Communities;Community Health;Community Healthcare;Consultations;Continuity of Patient Care;cost;Cost Analysis;cost effectiveness;dashboard;Data;design;Diagnostic;E-learning;Early Diagnosis;early screening;economic evaluation;Education;effectiveness evaluation;Eligibility Determination;Ensure;experience;follow-up;future implementation;Goals;Government;Growth;handheld mobile device;Health care facility;health care settings;Health Personnel;Health system;implementation evaluation;implementation facilitators;implementation outcomes;implementation science;improved outcome;Incidence;India;Individual;Infrastructure;innovation;Investments;Knowledge;Link;low and middle-income countries;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;medical schools;men;Methods;mHealth;mhealth interventions;mobile application;mobile computing;mortality;multi-component intervention;novel strategies;Nurses;Outcome;patient oriented;Patients;Phase;Physicians;Pilot Projects;pilot test;Policies;policy implication;population based;Primary Care;primary care provider;Process;Provider;Resource-limited setting;Risk Factors;scale up;screening;Screening for cancer;screening guidelines;success;symposium;Symptoms;Testing;theories;Time;tool;Training;Update;uptake;usability;volunteer;Woman

PROJECT_TITLE: Multicomponent mhealth interventions for healthcare providers and the community to increase cancer screening in India

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-X (57)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Cystic Fibrosis;Genetics;Infectious Diseases;Lung;Prevention;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOLOGY

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research focuses on understanding how the opportunistic pathogen Pseudomonas aeruginosa evolves during growth in building premise plumbing biofilms, and how this evolution impacts downstream infection pathogenesis. This project will provide fundamental knowledge about microbial persistence in premise plumbing and in the host that is relevant to public health because potable water is a major source of bacteria that cause opportunistic infections. This work is relevant to the mission of the NIH because it is expected to inform development of therapeutic, public health, or engineering-based interventions to prevent infections seeded by premise plumbing biofilms, thereby reducing the disease burden from waterborne opportunistic pathogens.

PI_NAMEs: ARMBRUSTER, CATHERINE REBECCA (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Acute;Alleles;Amoeba genus;anti-microbial tolerance;antimicrobial;Antimicrobial Resistance;Award;Bacteria;Biological Models;bronchial epithelium;burden of illness;career;career development;CCRL2 gene;Cell Communication;Cells;Chemicals;Chloramines;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Communities;comparative genomics;Complement;Coupled;Cystic Fibrosis;cystic fibrosis airway;cystic fibrosis infection;Data;Disease Outbreaks;Disinfectants;Disinfection;Ear;Economic Burden;Engineering;Environment;Epithelial Cells;Evolution;Exposure to;Eye;Faculty;fitness;Foundations;Genes;Genetic;Genetic Diseases;Genetic Screening;Genome;Genomics;Goals;Growth;hookah;Imaging Techniques;immune phagocytosis;Immune response;Immunocompromised Host;Infection;Infection prevention;Inflammatory;insight;Intervention;Job Application;Knowledge;Laboratories;Life;Life Style;Link;Lipopolysaccharides;Macrophage;Maps;metatranscriptomics;Microbe;microbial;Microbial Biofilms;microbiota;Mission;Modeling;mucosal site;Mutation;Nutrient;Nutritional;Nutritional Immunity;Operative Surgical Procedures;Opportunistic Infections;opportunistic pathogen;Outcome;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Persons;Phagocytosis;Phenotype;Physiological;Plumbing;polymicrobial biofilm;Population;Positioning Attribute;Postdoctoral Fellow;pressure;programs;Protocols documentation;Pseudomonas aeruginosa;Public Health;Research;Residual state;Respiratory Disease;Respiratory System;Respiratory Tract Infections;response;Scientist;Shapes;Signal Transduction;Site;Source;Structure;success;surface coating;Testing;therapeutic development;Training;trait;Tropism;United States National Institutes of Health;Urinary tract;Virulence;Water;waterborne;Work;wound

PROJECT_TITLE: Evolution of Pseudomonas aeruginosa in premise plumbing and impact on cystic fibrosis respiratory disease pathogenesis

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Research Study Section[MID]


NIH_SPENDING_CATS: Biotechnology;Complementary and Integrative Health;Genetics;Human Genome;Microbiome

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE Commensal gut protists shape the bacterial composition of the human gut microbiome and protect against inflammatory bowel diseases. However, how protists interact with other microbes and contribute to the gut metabolic environment to cause these outcomes are unclear. This work will use genomics and defined culture- based approaches to determine mechanisms of protist-bacteria and protist-host interactions, with the potential to support the use of commensal protists and their metabolites in therapies.

PI_NAMEs: LIND, ABIGAIL  (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Advisory Committees;Algae;Archaea;Architecture;Award;axenic culture;Bacteria;bacterial community;Belief;Biological Process;Biology;Blastocystis;career;Chemicals;Coculture Techniques;cohort;Data;Data Set;Diatoms;Disease;Ecosystem;Environment;Eukaryota;Exclusion;experimental study;fecal transplantation;fungus;Future;Gene Expression Profiling;Genes;Genetic Recombination;Genome;genome annotation;Genomics;Growth;gut inflammation;gut microbiome;gut microbiota;Health;Hi-C;Human;Human Microbiome;Immune system;In Vitro;in vivo;Individual;Inflammatory Bowel Diseases;Intervention;Life;Life Cycle Stages;Literature;live cell imaging;Measures;Medical;Medical History;member;Metabolic;metabolome;metabolomics;metagenomic sequencing;Methods;Microbe;microbial;microbiome;microbiome components;microbiome research;microbiome sequencing;novel strategies;Organism;Outcome;pan-genome;Pathogenicity;Pathway interactions;Population Analysis;Predatory Behavior;Probiotics;Production;programs;Recording of previous events;Repression;Research;Role;Sampling;Shapes;Shotguns;small molecule;Source;success;System;Testing;transcriptomics;transplantation therapy;Virus;Work;Zoonoses

PROJECT_TITLE: Protective impacts of commensal protists on the human gut microbiome

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: AA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: PROJECT NARRATIVE The Vanderbilt AUD Research and Education Center (VAREC) will perform iterative forward- and reverse-translational research exploring key circuitries underpinning specific components of Alcohol Use Disorder (AUD). VAREC will also engage the public through near-peer and podcast-style educational approaches to destigmatizing discussion of AUD and engage the alcohol research community through short courses aimed at incorporation of modern neuroscience technologies across the neuroscience of AUD research landscape.

PI_NAMEs: CALIPARI, ERIN  (contact);WINDER, DANNY G.

PROGRAM_OFFICER_NAME: GRAKALIC, IVANA

PROJECT_TERMS: Abstinence;Adolescent;affective disturbance;alcohol abstinence;alcohol exposure;alcohol misuse;alcohol reinforcement;alcohol research;alcohol seeking behavior;alcohol use disorder;Alcohols;Animal Experimentation;Animal Model;Anxiety;Behavior;behavior prediction;Behavioral Paradigm;Brain;Brain imaging;Chronic;Collaborations;Communities;computerized tools;depressive symptoms;design;Development;Disease;Disease Progression;drinking;drinking behavior;Dynorphins;Education;effective therapy;Endocannabinoids;endophenotype;Etiology;Faculty;Fellowship;Funding;Genes;Goals;Heavy Drinking;Hippocampus;Human;human imaging;human model;Human Subject Research;imaging study;Individual Differences;insight;Insula of Reil;Investigation;Knowledge;Lead;Mainstreaming;Mental Depression;Methods;Modeling;Modernization;mouse model;Mus;negative affect;Negative Reinforcements;neuroimaging;Neurosciences;novel;novel strategies;novel therapeutic intervention;Participant;Pathway interactions;peer;Persons;Phenotype;Play;podcast;Population;Prevention;programs;Public Health;Research;Research Infrastructure;Research Personnel;Resources;Role;Rural Community;Sampling;segregation;Signal Transduction;Structure;Structure of terminal stria nuclei of preoptic region;Students;success;Symptoms;Technology;Testing;Therapeutic;therapeutic evaluation;therapeutic target;Time;tool;transcriptome sequencing;Translating;translational approach;Translational Research;Underrepresented Populations;underserved community;Underserved Population;Universities;Woman;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 DD (60)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse

PI_NAMEs: WINDER, DANNY G. (contact)

PROJECT_TERMS: Advisory Committees;alcohol research;Alcohols;Animal Model;ARHGEF5 gene;base;Basic Science;Budgets;career;Communication;Communities;Consultations;Data;data sharing;Development;Education;endophenotype;Ensure;Environment;Fostering;Funding;Future;Goals;Growth;Health;human model;Human Resources;improved;Individual;infrastructure development;Institution;Leadership;Link;medical schools;meetings;Modeling;National Institute on Alcohol Abuse and Alcoholism;Neurosciences;operation;Outcome;Pathway interactions;Positioning Attribute;programs;Progress Reports;public education;Publishing;Research;Research Personnel;Research Priority;Research Project Grants;Research Support;Resource Sharing;Resources;Running;Stigmatization;Strategic Planning;Structure;Technology;Testing;Therapeutic;Training;Work

PROJECT_TITLE: VAREC Administrative Core


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Data Science;Neurosciences;Substance Misuse

PI_NAMEs: SICILIANO, CODY  (contact)

PROJECT_TERMS: 3D Print;Abstinence;addiction;Alcohol abuse;alcohol availability;alcohol behavior;Alcohol consumption;alcohol exposure;alcohol measurement;alcohol reinforcement;alcohol research;Alcohols;analysis pipeline;Anatomy;Animal Experimentation;Animal Model;Animals;annotation  system;Behavior;Behavioral;Behavioral Model;behavioral outcome;behavioral phenotyping;Big Data;Biological Assay;Blood;Brain;Brain imaging;Chronic;Clinical;Collaborations;Complex;Computer Analysis;computer infrastructure;Computers;computing resources;Concentration measurement;conditioning;cost;cryostat;Custom;Data;Data Aggregation;Data Analyses;data pipeline;Data Set;Data Storage and Retrieval;Dedications;Dimensions;disease model;Disparate;drinking;Education;Electronics;Equipment;Ethanol;experimental study;Failure;Female;Floor;Fluorescence Microscopy;Funding;Generations;Goals;Home;Human;Human Resources;Image;Individual;Individual Differences;Infrastructure;Intake;Laboratories;Laboratory Study;Leadership;Light;Literature;Machine Learning;Meta-Analysis;metabolic phenotype;Metadata;Methodology;Modeling;Modernization;Mus;neural;Neurons;Neurosciences;neurotechnology;Operative Surgical Procedures;Outcome;Pathway Analysis;Phase;Phenotype;pre-clinical;preclinical study;Privatization;Procedures;Productivity;Quality Control;Quinine;Reagent;relational database;Reproducibility;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;Role;Running;Sampling;Secure;Site;Standardization;Structure;Study models;success;synergism;Testing;Training;Translations;virtual;Water

PROJECT_TITLE: VAREC Research Core


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Neurosciences;Pediatric;Rural Health;Substance Misuse

PI_NAMEs: CALIPARI, ERIN  (contact)

PROJECT_TERMS: Academy;Address;Alcohol consumption;alcohol research;alcohol use disorder;Area;Award;Basic Science;Brain;BRAIN initiative;Collaborations;Communication;Communities;community engagement;community research;COVID-19 pandemic;Data;Data Analyses;design;Development;Disease;disorder prevention;Education;education resources;empowerment;Ensure;Equipment;experience;Faculty;Feeling;Fellowship;Funding;Future;Goals;Grant;high school;High School Student;Historically Black Colleges and Universities;Housing;Hybrids;in vivo;innovation;junior high school;Knowledge;Laboratories;Mathematics;member;metabolic phenotype;Middle School Student;Midwestern United States;Mission;Modeling;Modernization;Mus;Nature;Neuronal Dysfunction;Neurosciences;novel;novel strategies;online community;Organ;Participant;peer;peer coaching;Persons;programs;Research;Research Personnel;Resources;Rural;Schools;Science;Series;social media;Societal Factors;student mentoring;Students;success;summer research;Technology;Teenagers;Tennessee;tool;Training;Training and Education;Travel;undergraduate research experience;undergraduate student;Underrepresented Populations;underserved community;United States;virtual;Work

PROJECT_TITLE: VAREC Dissemination Core


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Recovery Support Services;Substance Misuse

PI_NAMEs: BLACKFORD, JENNIFER URBANO (contact)

PROJECT_TERMS: Abstinence;Acute;addiction;Address;Affect;alcohol abstinence;alcohol abuse therapy;Alcohol dependence;alcohol exposure;alcohol research;alcohol seeking behavior;alcohol use disorder;Alcohol withdrawal syndrome;American;Amygdaloid structure;Anatomy;Animal Model;Anxiety;anxiety symptoms;anxiety-like behavior;Behavior;Brain;Characteristics;Chronic;clinically significant;Collaborations;Data;depressive symptoms;Development;Diffusion Magnetic Resonance Imaging;Disabling;Education;Functional Magnetic Resonance Imaging;Funding;Future;Goals;Heterogeneity;Hippocampus;Human;Hypothalamic structure;imaging modality;Individual;Individual Differences;Infrastructure;innovation;Insula of Reil;Intervention;Knowledge;long term recovery;Measures;Mental Depression;Methods;Modeling;National Institute on Alcohol Abuse and Alcoholism;negative affect;Negative Reinforcements;neural;neural circuit;Neurobiology;neuroimaging;Neurosciences;novel;Nucleus Accumbens;Pathway interactions;Pattern;personalized medicine;Phenotype;Pilot Projects;Prefrontal Cortex;prevent;Process;reduce symptoms;Relapse;relapse prevention;Reporting;Research;Residential Treatment;response;Rest;Rodent;Rodent Model;Sampling;Structure of terminal stria nuclei of preoptic region;Subgroup;success;Symptoms;Technology;Testing;Time;Translating;translation to humans;translational study;Translations;treatment program;Variant;Withdrawal;Work

PROJECT_TITLE: Investigating individual differences in alcohol abstinence associated anxiety and depression across the BNST network.


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biomedical Imaging;Brain Disorders;Cannabinoid Research;Endocannabinoid System Research;Neurosciences;Substance Misuse

PROJECT_TERMS: 2-arachidonylglycerol;Abstinence;affective disturbance;alcohol abstinence;Alcohol consumption;alcohol reinforcement;alcohol seeking behavior;alcohol use disorder;Alcohols;Anatomy;Animal Model;Behavior;biological adaptation to stress;Brain imaging;Chronic;CNR1 gene;Collaborations;Complex;conditional knockout;Corticosterone;Data;data modeling;Development;Disease;drinking;Education;endocannabinoid signaling;Endocannabinoids;endogenous cannabinoid system;endophenotype;Excision;experience;Female;Future;genetic approach;Hippocampus;Human;human data;human imaging;Hypothalamic structure;Image;imaging study;insight;Insula of Reil;interest;Lead;Light;lipoprotein lipase;male;Maps;men;Modeling;Molecular;mouse model;Mus;negative affect;neural circuit;Neurosciences;novel;novel therapeutics;optogenetics;Pathway interactions;Pattern;Peripheral;Phase;Phenotype;Pituitary Gland;Play;preclinical study;Process;Protocols documentation;Regulation;Research;Rest;Rodent;Rodent Model;Role;Structure of terminal stria nuclei of preoptic region;Study models;Subcategory;Synapses;synthetic enzyme;System;Testing;theories;Therapeutic;tractography;Training;Translations;Withdrawal;Woman

PROJECT_TITLE: Reverse translation of human brain imaging data in mouse models of AUD


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Prevention;Substance Misuse;Substance Misuse Prevention;Women's Health Research

PROJECT_TERMS: Abstinence;Affective;Affinity Chromatography;alcohol abstinence;Alcohol consumption;alcohol cue;alcohol exposure;alcohol measurement;alcohol prevention;alcohol research;alcohol seeking behavior;alcohol use disorder;Alcohols;Animals;Aversive Stimulus;awake;Behavior;Behavioral;behavioral phenotyping;binge drinking;biological sex;Brain region;cell type;Cells;Consumption;Data;designer receptors exclusively activated by designer drugs;Dopamine D1 Receptor;drinking;Education;endophenotype;Female;Future;Gene Expression Profiling;Human;human data;in vivo;Individual;Learning;Machine Learning;male;Mediating;microendoscopy;Modeling;Molecular;Mus;negative affect;Negative Reinforcements;neural;neural circuit;Neurons;Neurosciences;next generation;Nucleus Accumbens;Optics;Outcome;Pattern;Performance;Phenotype;Physiological;Population;Process;Proteome;Psychological reinforcement;Research;response;Ribosomes;Rodent;Role;sex;Sex Differences;sexual dimorphism;Stimulus;System;tool;transcriptome;transcriptome sequencing;Translating;Work

PROJECT_TITLE: Targeting the neural circuits controlling negative reinforcement to prevent alcohol seeking in males and females


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Neurosciences;Opioids;Substance Misuse

PROJECT_TERMS: Acute;Address;adverse outcome;Affinity;Agonist;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol effect;alcohol exposure;alcohol intervention;alcohol reinforcement;alcohol research;alcohol use disorder;Alcohols;Anatomy;antagonist;Area;Behavior;Behavioral;Brain;Brain region;Calcium;Cessation of life;Chronic;Clinical;Consensus;Data;design;Development;Disease;Disease Progression;drinking;drinking behavior;drug development;Dyes;Dynorphins;Education;Electrophysiology (science);endogenous opioids;experimental study;Female;Fluorescein;Foundations;frontier;Functional disorder;global health;Goals;Human;Image;Individual;Individual Differences;insight;Intake;interest;Intervention;Investigation;kappa opioid receptors;Knowledge;Libraries;Ligands;Link;Literature;male;Mediating;Mediator;midbrain central gray substance;multiphoton microscopy;Mus;nalmefene;Naloxone;Naltrexone;Neurons;neurophysiology;novel;Opioid Antagonist;Outcome;patch clamp;Pattern;personalized intervention;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Pharmacology;Phenotype;pre-clinical;Pre-Clinical Model;Precision therapeutics;Predisposition;premature;Property;receptor;Receptor Activation;receptor expression;Regulation;Research;research clinical testing;Resolution;Resources;response;Rodent;Rodent Model;Role;screening;Self Administration;sensor;Site;Slice;spatiotemporal;Structure;symptomatology;System;Testing;Tissues;treatment strategy

PROJECT_TITLE: Preclinical approaches for advancing precision applications of kappa-opioid receptor ligands in AUD treatment


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: The lack of cures and prevention of Alzheimer’s disease (AD) stems in part from an incomplete understanding of the aggregation of plaque-forming Amyloid beta protein, and by the role of another protein, ApoE, a biomarker of AD. We seek to understand these proteins in vitro and in reprogrammed neurons from individuals who have AD.

PI_NAMEs: GROSS, MICHAEL L (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: abeta accumulation;Adult;Age;age related;aggregation pathway;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer’s disease biomarker;American;Amino Acids;Amyloid;Amyloid beta-Protein;Amyloid Proteins;Animals;Antibodies;Apolipoprotein E;apolipoprotein E-4;Binding;carbene;Cell membrane;Cells;Chemicals;Chemistry;Clinical;Collaborations;Complement;Complex;computerized data processing;Coupled;Cryoelectron Microscopy;Data;density;Dependence;Deuterium;Development;Device or Instrument Development;Disease;disorder prevention;Entropy;experience;experimental study;Family;Fibroblasts;Field Flow Fractionation;Filament;Foundations;Free Radicals;Functional disorder;Goals;Grant;Heterogeneity;Human;Hydrogen;Hydrogen Bonding;In Vitro;in vivo;Individual;inhibitor;insight;instrumentation;invention;kinetic model;Kinetics;Label;Laboratories;Ligand Binding;Lipids;Mass Spectrum Analysis;mathematical model;Measures;Membrane;method development;Methods;Modeling;Modification;Molecular;Molecular Sieve Chromatography;monomer;Morphology;mouse model;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neurons;neurotoxic;novel;novel strategies;novel therapeutics;Outcome;oxidation;Parkinson Disease;Pathogenesis;Patients;Peptides;Physiologic pulse;Pluripotent Stem Cells;Population;Preventive;protein aggregation;Protein Footprinting;Protein Isoforms;Proteins;Proteomics;Protocols documentation;Qualifying;Rationalization;Reagent;Research;Resolution;Role;sensor;Site;small molecule;small molecule inhibitor;solid state;solid state nuclear magnetic resonance;Solvents;Specificity;stem;stem cell model;Structure;System;Techniques;Testing;theories;Therapeutic;Thinking;Time;tool;United States National Institutes of Health;Validation

PROJECT_TITLE: Mass Spectrometry-Based Protein Footprinting: A New Tool for Amyloid Protein Aggregation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-B (80)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: Patients with social risk factors, including poverty, being a minority, lack of an education, and living in rural areas are all associated with having worse health outcomes and having more difficulties recovering after surgical procedures. We will study the effect of social risk factors and rurality on health outcomes after surgery to identify patients that would benefit from care pathways that help poor people. One problem is that medical records usually do not contain information about social risk factors. We will use multiple data sources to try to determine which social risk factors have the most effect on surgical outcomes. These studies will help us understand outcomes in patients receiving care within and outside of the VA and how to use that data to improve our ability to identify patients that need extra help. In addition, a better understanding of which social risk factors lead to poor outcomes will help us to design care pathways that provide services and treatments that will improve outcomes after surgery.

PI_NAMEs: HAUSMANN, LESLIE R (contact)

PROJECT_TERMS: Acute;Address;Administrator;Affect;American;Area;Assessment tool;barrier to care;Benchmarking;burden of illness;care delivery;care fragmentation;care outcomes;Caring;Communities;Community Surveys;comorbidity;cost;Data;Data Collection;Data Set;Data Sources;data warehouse;deprivation;design;Disparity;Distress;diverse data;economic disparity;economic evaluation;Education;Educational process of instructing;Eligibility Determination;Ethnic Origin;Failure;Fees;frailty;Goals;Health;health care disparity;health care service utilization;health equity;Health Services Accessibility;Health system;Healthcare;high risk;hospital performance;hospital readmission;Hospitals;improved;improved outcome;indexing;Individual;Informatics;innovation;Inpatients;Institution;Institutional Practice;Lead;Length of Stay;low socioeconomic status;Machine Learning;machine learning method;machine learning model;Manuscripts;Measures;Medical;Medical Records;Methodology;Methods;military veteran;Minority;Minority Status;Mission;Modeling;mortality;multiple data sources;neighborhood disadvantage;Operative Surgical Procedures;Outcome;Outcome Assessment;outcome prediction;Pathway interactions;patient stratification;Patients;payment;Peer Group;Performance;Perioperative;Persons;Phase;point of care;Policies;poor health outcome;Population;Postoperative Complications;Postoperative Period;Poverty;predictive modeling;Procedures;programs;Proxy;Race;racial minority status;residence;Resource Allocation;Resources;Risk;Risk Adjustment;Risk Factors;risk mitigation;rural area;Rural Health;rurality;safety net;Services;social;Socioeconomic Status;statistics;surgery outcome;Surgical complication;Surgical Models;surgical risk;System;Techniques;trend;United States;United States Centers for Medicare and Medicaid Services;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;Vulnerable Populations

PROJECT_TITLE: Understanding the effect of rurality and social risk factors on barriers to care and surgical outcomes.

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


ORG_CITY: BEDFORD

ORG_NAME: EDITH NOURSE  ROGERS MEMORIAL VETERANS HOSPITAL

PHR: VA seeks to promote patient-centered care in which Veterans' personal values, goals, and preferences drive health care plans. Cancer screening often involves a complex process whereby patients who do not exhibit any symptoms participate in repeated testing over sometimes inconsistent intervals over many years. Clinical recommendations do not account for variation in these perceptions over the course of cancer screening, and little is known about how they change over time and between screening intervals. Using lung and breast cancer screening initiatives as cases, this work will generate greater understanding of how perceptions of risk change throughout the screening process. We will develop guidance and materials for patients and providers to facilitate patient-centered shared decision-making in repeat cancer screening.

PI_NAMEs: GILLESPIE, CHRISTOPHER  (contact)

PROJECT_TERMS: Adherence;Affect;Age;Area;Benefits and Risks;Biopsy;Breast Cancer Detection;cancer initiation;cancer risk;Caring;Clinical;Collaborations;Communication;Complex;Data;Decision Making;design;Development;disorder prevention;Elements;Eligibility Determination;empowerment;Evaluation;experience;Failure;Family;Focus Groups;follow-up;Frequencies;Goals;Health;health belief;Health Promotion;Healthcare;Image;improved;innovation;insight;Interview;Knowledge;lung cancer screening;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Methodology;Modeling;Oncology;Outcome;outreach;participant interview;Patient Compliance;patient engagement;patient oriented;Patient risk;Patient-Centered Care;Patients;Perception;Persons;preference;Preventive;Process;programs;Provider;provider communication;Qualitative Research;Recommendation;Recording of previous events;Reporting;Research;Risk;Risk Factors;risk perception;routine screening;screening;Screening for cancer;screening program;Screening Result;shared decision making;Source;Specific qualifier value;success;Symptoms;Testing;Time;Tobacco use;Uncertainty;uptake;Variant;Veterans;whole health;Woman;Work

PROJECT_TITLE: Patient Risk Perception and Decision-Making about Adherence to Repeat Cancer Scr


ORG_CITY: SALT LAKE CITY

ORG_NAME: VA SALT LAKE CITY HEALTHCARE SYSTEM

ORG_STATE: UT

PHR: Poverty has a devastating effect on Veterans’ health and well-being. Through the Shallow Subsidy program, Veterans and their families living in 15 high-cost communities throughout the country who are experiencing housing instability can receive long-term rental assistance and job training with the long-term financial self- sufficiency. The impact of the Shallow Subsidy program on Veteran housing, healthcare cost, health, income, and employment outcomes as well as Veteran experience with this new program is not known. Through this project, we will generate important information about the Shallow Subsidy program. We will use nationwide data to describe the geographic variation in Shallow Subsidy services and expenditures throughout the different, eligible communities. We will measure the impact of Shallow Subsidy on Veteran outcomes as well as the cost-effectiveness of the program relative to usual care. Finally, we will interview Shallow Subsidy participants to better understand barriers and facilitators of the program.

PI_NAMEs: NELSON, RICHARD E. (contact)

PROJECT_TERMS: Address;Attitude;Characteristics;Clinical Data;Cohort Analysis;combat injury;Communities;cost;cost effective;cost effectiveness;cost outcomes;Country;Data;Data Files;Death Rate;design;Economic Conditions;economic evaluation;economic outcome;Economics;Effectiveness;Eligibility Determination;Employee;Employment;Enrollment;Expenditure;experience;Family;Financial Support;Funding;Future;geographic difference;Geographic Locations;Goals;Health;Health Care Costs;health economics;Healthcare Systems;Heterogeneity;Homelessness;Housing;housing instability;implementation facilitators;implementation strategy;improved;Income;Individual;innovation;insight;Intervention;Interview;Literature;Living Costs;Location;Management Information Systems;Measures;Methodology;Methods;Modeling;models and simulation;mortality;Nonprofit Organizations;Occupations;operation;opioid misuse;Outcome;Outcome Assessment;Paper;Participant;Personal Satisfaction;policy recommendation;Population;Poverty;Program Effectiveness;programs;Publishing;Quality-Adjusted Life Years;relative effectiveness;Reporting;Research;Research Design;Research Project Grants;Resources;Retrospective cohort;Risk;satisfaction;Savings;service providers;Service provision;Services;social;social health determinants;Societies;Source;Structure;structured data;supported housing;Taxes;Training;Training Programs;Traumatic Brain Injury;treatment as usual;unstructured data;Veterans;Vulnerable Populations;Work

PROJECT_TITLE: Assessing an Initiative to Facilitate Long-Term Financial and Housing Stability in Vulnerable Veterans

STUDY_SECTION_NAME: Social Determinants of Health[HS2A]


ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: There is increased attention on social determinants of health (SDOH) as a result of empirical evidence showing that the patient’s social background is associated with their health behaviors and clinical outcomes. Now more than ever, health care systems (HCS) are being held accountable for addressing social factors. Improving the quality of health care among racial and ethnic minorities is a VA priority. A systematic approach is needed for Health information technology (HIT) to be effective at addressing minority health and health disparities. Our project will use HIT to address the SDOHs that contribute to health disparities in minority populations and other medically underserved groups as a multi-step process that involves identifying patients who have social risk factors and implementing an assessment system with the goal of improving the outcomes of Veterans.

PI_NAMEs: FREY, LEWIS JAMES (contact);HUGHES-HALBERT, CHANITA A.

PROJECT_TERMS: Accountability;Address;Algorithms;Attention;Cardiovascular Diseases;care outcomes;Caring;Clinic;Clinical;Clinical Data;clinically actionable;Code;cohort;Communication;Communities;community based service;Data;Data Sources;deep learning;Development;Diabetes Mellitus;disorder prevention;distrust;Documentation;Education;Effectiveness;Electronic Health Record;ethnic minority;ethnic minority population;Financial Hardship;food insecurity;Goals;Health;Health behavior;health care quality;health care service organization;health disparity;health information technology;health management;Health Personnel;Healthcare Systems;improved;improved outcome;Income;innovation;Insurance Carriers;International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10);learning strategy;Machine Learning;male health;Manuals;Medical;Medical center;medically underserved population;medicine man;Methodology;Methods;Minority;Minority Groups;minority health;minority health disparity;Minority Men;Natural Language Processing;Nature;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;Patient Self-Report;Patient-Focused Outcomes;Patients;Phenotype;Physicians;population health;precision medicine;Primary Care;primary care patient;Process;Provider;Public Health Informatics;racial minority;racial minority population;Recommendation;Reporting;Research Personnel;Resources;Risk;Risk Factors;Role;routine care;Services;social;social determinants;social factors;social health determinants;Social isolation;Social Work;socioeconomics;South Carolina;Standardization;Structure;System;tool;Trust;United States Department of Veterans Affairs;Universities;Veterans;Veterans Health Administration;Visit

PROJECT_TITLE: Data-Driven Methods to Identify Social Determinants of Health


ORG_NAME: PORTLAND VA MEDICAL CENTER

PHR: Among Veterans over 50 years old, 17% actively smoke cigarettes. Teachable Moment to Opt- Out of Tobacco (TeaM OUT) is a smoking cessation intervention designed to make use of interactive voice response (IVR) technology in order to engage with patients during a possible teachable moment: the discovery of a pulmonary nodule. This project will evaluate whether a pragmatic, proactive, low-cost solution, that takes advantage of a naturally occurring teachable moment, can increase smoking abstinence in this group as well as provide generalizable results for patients in multiple settings and situations.

PI_NAMEs: SLATORE, CHRISTOPHER G. (contact)

PROJECT_TERMS: Abstinence;Adoption;Adult;American;arm;behavior change;Biochemical;cancer diagnosis;Categories;Chest;cigarette smoke;cigarette smoking;Clinical;clinical encounter;Cluster randomized trial;Code;Communication;Consolidated Framework for Implementation Research;Control Groups;cost;Counseling;Data;data de-identification;design;Diagnosis;Disease;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;Electronic Health Record;Elements;Enrollment;experience;Exposure to;future implementation;Geography;Health Hazards;Health Professional;Health Services Research;Healthcare;high risk;implementation barriers;implementation facilitators;implementation process;Individual;innovation;Institutional Review Boards;Intervention;Interview;Knowledge;Letters;Link;Logistic Regressions;Lung nodule;Measures;Methodology;Methods;Motivation;Newly Diagnosed;Nicotine;Nodule;Notification;novel;older adult;Outcome;outreach;Participant;patient engagement;Patient Outcomes Assessments;Patients;Persons;Pharmaceutical Preparations;Population;pragmatic intervention;Prevalence;primary outcome;Publications;quitline;Randomized;Readiness;Recommendation;Registries;repository;Research;Research Personnel;Resources;response;secondary outcome;Services;Smoke;Smoker;Smoking;smoking abstinence;smoking cessation;Smoking Cessation Intervention;Societies;stakeholder perspectives;Suggestion;Surveys;symposium;System;Technology;Telephone;Testing;therapy design;Time;Tobacco;Tobacco Dependence;treatment arm;treatment as usual;United States Preventative Services Task Force;usual care arm;Veterans;Voice

PROJECT_TITLE: Teachable Moment to Opt-Out of Tobacco (TeaM OUT): A Stepped Wedge Cluster Randomized Trial

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


ORG_CITY: SEATTLE

ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

PHR: Project Narrative Posttraumatic Stress Disorder (PTSD) is common among Veterans and results in poor psychological functioning, quality of life, and physical health. This includes having disproportionately high rates of obesity, in part due to PTSD symptoms interfering with physical activity and healthy diet. Unfortunately, Veterans with PTSD have poorer weight loss outcomes than those without PTSD in VA’s existing weight management program, MOVE!. Based on pilot work, it appears that a weight management program that augments standard PTSD care and targets PTSD-related barriers to weight loss improves weight and PTSD symptoms. Whether it improves these issues more than standard VA care is in need of study, which is the focus of the proposed research. The proposed study also seeks to understand factors that would interfere with and facilitate implementing the program in VA if it is effective. This Veteran-centered, tailored weight loss program may efficiently benefit both physical and mental health of Veterans with PTSD, addressing standard care limitations.

PI_NAMEs: HOERSTER, KATHERINE  (contact)

PROJECT_TERMS: Active Learning;Address;Behavioral;Binge Eating;Body Weight decreased;Cardiovascular Diseases;Caring;Cognitive Therapy;cohort;Communities;comparison control;cost;cost effective;Counseling;Coupled;Data;design;diabetes risk;diagnostic criteria;disorder prevention;Eating Behavior;Effectiveness;enhanced care;Enrollment;evidence base;Funding;Future;future implementation;good diet;Health behavior;Health Promotion;Health Services Accessibility;Healthy Eating;Hour;hybrid type 1 trial;implementation barriers;implementation facilitators;improved;Individual;innovation;insight;Intervention;intervention participants;K-Series Research Career Programs;Learning;meetings;Mental Depression;Mental disorders;Mental Health;Mental health promotion;Methodology;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity risk;Outcome;Overweight;Participant;patient oriented;Patients;peer support;Persons;Pharmaceutical Preparations;Physical activity;physical conditioning;Positioning Attribute;Post-Traumatic Stress Disorders;Premature Mortality;prevention service;primary outcome;Professional counselor;programs;psychologic;Psychologist;Psychotherapy;Quality of life;Randomized;randomized trial;Recommendation;Recovery;reduce symptoms;Reporting;Research;Risk;Risk Reduction;satisfaction;Services;Site;skills;Sleeplessness;Social support;standard care;Suicide prevention;Symptoms;Testing;Translations;treatment as usual;Unhealthy Diet;Veterans;Visit;Walking;Weight;weight loss program;Weight maintenance regimen;Well in self;whole health;Work

PROJECT_TITLE: MOVE!+UP: Testing a Tailored Weight Management Program for Veterans with PTSD

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

ORG_STATE: CA

PHR: There is increasing recognition that social determinants of health (SDHs)–personal circumstances and environmental factors that shape an individual’s daily life–contribute to meaningful variation in clinical and economic outcomes. Systematic procedures for assessing and addressing SDHs in health care settings could improve prevention and treatment efforts. In order for the Veterans Affairs (VA) system to achieve this goal, there is a need to evaluate the impact of SDHs in Veterans to determine the best candidates for integration into the electronic health record. The proposed study will leverage national surveys of the general VA population and Veterans at high-risk for hospitalization to identify SDH factors associated with health care utilization, cost, community bed days, and patient experience outcomes. We will partner with VA leadership, clinicians, patients, and caregivers, to prioritize SDHs that are actionable (i.e., addressable through VA or community services) and develop recommendations for SDH measure screening procedures and electronic health record integration.

PI_NAMEs: MACIEJEWSKI, MATTHEW L;ZULMAN, DONNA MICHELLE (contact)

PROJECT_TERMS: Academy;Accident and Emergency department;Address;Affect;Area;Bed Occupancy;Behavioral;Businesses;candidate identification;Caregivers;Caring;Clinical;clinical care;Communities;Community Healthcare;Community Services;cost;Coupled;COVID-19;COVID-19 pandemic;Data;Disadvantaged;Disparity;Disparity population;economic outcome;Economics;Electronic Health Record;Emergency department visit;Environmental Risk Factor;ethnic minority;Evaluation;experience;Financial Hardship;food insecurity;Funding;Future;Goals;Health;Health Care Costs;health care service utilization;health care settings;health determinants;health disparity;health equity;health record;Health system;Healthcare;high risk;Hospital Departments;Hospitalization;Hospitals;housing instability;implementation barriers;implementation facilitators;improved;Individual;innovation;Integrated Health Care Systems;interoperability;Intervention;Interview;Lead;Leadership;Life;Light;Link;Measurement;Measures;Medicare;Medicine;Methodology;Minority;Modeling;operation;Outcome;outcome prediction;patient population;Patients;point of care;Population;Positioning Attribute;Predictive Value;Prevalence;Prevention;Primary Care;Procedures;Process;racial minority;Recommendation;Reporting;Research;Research Personnel;Respondent;Rest;Risk;Risk Adjustment;Rural;Rural Health;Sampling;screening;Screening procedure;Shapes;social;social factors;social health determinants;Social isolation;social vulnerability;Surveys;System;Transportation;Trust;United States Department of Veterans Affairs;Variant;Veterans;Veterans Health Administration;Woman;Women's Health;Work

PROJECT_TITLE: Social and Behavioral Determinants of Health in High-Risk Veterans


ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE We have developed a highly novel gene therapy approach to achieve a functional cure for HIV, based on engineering B cells ex vivo to express HIV broadly neutralizing antibodies (bnABs). The approach is well suited for in vivo delivery because B cells are abundant and accessible in the body, and because modifying relatively few B cells is sufficient to generate the desired therapeutic effect. Here, we further develop in vivo delivery vectors in order to generate multi-specific bnAb responses for long-term HIV control.

PI_NAMEs: BARZEL, ADI ;CANNON, PAULA M;VOSS, JAMES EVEN (contact)

PROGRAM_OFFICER_NAME: POON, BETTY

PROJECT_TERMS: adeno-associated viral vector;Affinity;Animal Model;Animals;Antibodies;Antibody Response;Antibody Specificity;Antibody titer measurement;Antigen Receptors;Antigens;antiviral immunity;B-Cell Antigen Receptor;B-Lymphocytes;Biodistribution;Capsid;Cell secretion;Cells;Cellular biology;cellular engineering;Choristoma;Clonal Expansion;cost;CRISPR/Cas technology;Data;delivery vehicle;design;Development;DNA;DNA cassette;donor-specific antibody;Engineering;env Gene Products;Episome;Evaluation;Evolution;Gene Delivery;Gene Targeting;gene therapy;gene-editing approach;Genes;Genetic Transcription;genome editing;Goals;HIV;HIV vaccine;Human;Humoral Immunities;Immune system;Immunity;Immunocompetent;Immunoglobulin Class Switching;Immunoglobulin G;Immunoglobulin Switch Recombination;Immunoglobulins;Immunotherapy;improved;In Vitro;in vivo;Infection;Injections;Laboratories;Liver;Macaca;Macaca mulatta;Membrane;Memory;Modeling;Monitor;Monkeys;MS4A1 gene;Mus;Muscle;nanobodies;neutralizing antibody;nonhuman primate;novel;Plasma Cells;preservation;prevent;programs;promoter;Protein Isoforms;Protocols documentation;Publishing;Reagent;Receptor Cell;Recombinant Antibody;Recombinants;response;Route;Safety;Series;Serum;Signal Transduction;simian human immunodeficiency virus;Site;Specificity;Structure of germinal center of lymph node;System;Testing;Therapeutic Effect;therapeutic gene;Time;Transgenes;Vaccination;Vaccine Design;vector;Viral;Viral Antigens;viral rebound;Viremia;Virus;Virus Replication

PROJECT_TITLE: In vivo engineering of B cells for the secretion of HIV broadly neutralizing antibodies


NIH_SPENDING_CATS: Aging;Atherosclerosis;Bioengineering;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Nanotechnology

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Our long-term goal is to understand the cellular events that underlie the formation and growth of unstable atherosclerotic plaques in the arterial wall, which can cause heart attacks and strokes and represent the leading cause of death worldwide and are highly-relevant to the mission of the NIH. These vulnerable plaques are largely composed of macrophages and lipids deposited in the sub-endothelial layer of arteries resulting from chronic inflammation and endothelial cell injury or dysfunction. Because the liver is the primary site of lipid synthesis, we are unraveling the molecular mechanisms responsible for the activation of deleterious cell signaling pathways in the liver in an effort to identify new therapeutic targets to treat atherosclerosis.

PI_NAMEs: CHEN, HONG  (contact);SHI, JINJUN ;SRIVASTAVA, SANJAY

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: 3-hydroxy-3-methylglutaryl-coenzyme A;Adaptor Signaling Protein;Apolipoprotein E;Arterial Fatty Streak;Arteries;atherogenesis;Atherosclerosis;attenuation;Binding;Binding Proteins;Blood;blood lipid;Cardiovascular Diseases;Cause of Death;Cell Adhesion Molecules;cell injury;Cessation of life;Cholesterol;Chronic;Complement;Coronary heart disease;Deposition;design;Development;Diet;Disease;Down-Regulation;Dyslipidemias;effective therapy;Encapsulated;Endothelial Cells;Endothelium;epsin;epsin 1;Event;fighting;Foam Cells;Fortification;FOXO1A gene;Functional disorder;Generations;Genetic Transcription;Goals;Growth;Hepatocyte;Human;Hyperlipidemia;in vitro Model;Incidence;Inflammation;inhibitor;innovation;Ischemic Stroke;Knowledge;LDL Cholesterol Lipoproteins;Lesion;Life;Life Style;Lipids;Liver;Low Density Lipoprotein Receptor;Macrophage;Mass Spectrum Analysis;Mediating;Medicine;Mission;Modeling;Modernization;Molecular;monocyte;mouse model;Mus;Mutant Strains Mice;Myelogenous;Myocardial Infarction;nanoparticle;new therapeutic target;next generation;novel;novel strategies;novel therapeutic intervention;Nuclear Import;oxidized lipid;oxidized low density lipoprotein;Oxidoreductase;Patients;Peripheral arterial disease;Persons;Predisposition;prevent;Prevention program;Production;protective effect;protein activation;protein expression;Reagent;recruit;Regulatory Element;Research;Resolution;Risk Factors;Role;Rupture;Signal Pathway;Signal Transduction;Site;Small Interfering RNA;Sterols;Stroke;Subendothelial Layer;targeted treatment;Testing;Therapeutic;therapeutic evaluation;therapeutic target;transcription factor;transcriptome sequencing;translational potential;Triglycerides;ubiquitin ligase;Ubiquitination;United States;United States National Institutes of Health;vascular inflammation;western diet;Work

PROJECT_TITLE: The role of signaling adaptor protein epsin in atherosclerosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-D(02)M]


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: DURHAM

ORG_NAME: NORTH CAROLINA CENTRAL UNIVERSITY

ORG_STATE: NC

PHR: The STEM workforce, including the field of neuroscience, continues to lack racial and ethnic diversity. To reduce the disparity in the representation of Black and Latin-X neuroscience trainees, this proposal establishes a unique neuroscience fellowship opportunity at a Historically Black College and University (HBCU). This fellowship will diversify our neuroscience curriculum, expand the network of neuroscience peer and traditional mentors for trainees, and will allow fellows to establish themselves as leaders through undergraduate course development.

PI_NAMEs: COLE, GREGORY JAY;GRILLO, WENDY HECK;MARSHALL, SIMON ALEXANDER (contact)

PROGRAM_OFFICER_NAME: CHURCHILL, JAMES D

PROJECT_TERMS: Academia;Advocate;Affect;African American;African American population;Anecdotes;Biological Sciences;Black race;career;career networking;Chemistry;Collaborations;collaborative environment;Communities;Core Facility;course development;Degree program;demographics;design;Development;Disparity;disparity reduction;doctoral student;Educational Curriculum;Educational Status;Enrollment;Ensure;Environment;ethnic diversity;experience;Exposure to;Faculty;feeding;Feeling;Fellowship;Fostering;Foundations;Funding;Geographic Locations;Goals;graduate school;graduate student;Historically Black Colleges and Universities;Immersion;improved;Institution;interest;Investments;job market;Knowledge;laboratory curriculum;Lead;Leadership;Learning;lectures;matriculation;member;Mentors;Minority;Minority Groups;minority student;Minority-Serving Institution;Modeling;multidisciplinary;Nervous System Disorder;Neurologist;Neurosciences;Neurosciences Research;next generation;North Carolina;Ownership;peer;peer networks;Pharmacologic Substance;Population;programs;Psychiatrist;Publications;racial diversity;recruit;Research;Research Institute;role model;Science;STEM career;student mentoring;Students;success;Technical Expertise;Techniques;Training;training opportunity;undergraduate research;undergraduate student;Underrepresented Minority;underrepresented minority student;United States;Universities;university student

PROJECT_TITLE: Feeding the STEM Pipeline with Neuroscientist Trained at an HBCU


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Emergency Care;Health Services;Heart Disease

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative One million patients are hospitalized each year for the management of heart failure, and 25% of Medicare beneficiaries who are hospitalized for heart failure are readmitted within 30 days. Previous interventions designed to prevent readmissions in this population have had mixed results, possibly because they have not involved home health aides, who are often with patients post-discharge for prolonged periods of time. The goal of the proposed project is to develop and pilot test a novel intervention for home health aides caring for patients with heart failure, in order to avert avoidable readmissions and improve patient outcomes.

PI_NAMEs: STERLING, MADELINE R (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: 911 call;acceptability and feasibility;Accident and Emergency department;Active Learning;Address;Admission activity;Adult;Advisory Committees;Affect;Ambulatory Care;Area;Award;beneficiary;Cardiovascular Diseases;care coordination;care outcomes;career;caregiving;Caring;Clinical;clinical epidemiology;clinical implementation;Clinical Medicine;Clinical Trials;Communication;Communication difficulty;community collaboration;community engaged research;community partnership;Conduct Clinical Trials;cost;Data;design;Development;Discipline of Nursing;Education;Effectiveness;Electronics;Emergency department visit;Epidemiology;Evaluation;experience;feasibility testing;forging;Foundations;Funding;Future;Goals;Health;Health Care Costs;health care delivery;health information technology;Health Policy;Health Services Research;Health Surveys;Health Technology;Healthcare Systems;Heart failure;Home;Home Care Agencies;Home Care Services;Home Health Aides;hospital readmission;Hospitalization;Hour;implementation science;improved;improved outcome;Industry;innovation;Internist;Intervention;Intervention Trial;K-Series Research Career Programs;Knowledge;Learning;Licensing;Measures;Medical;Medical Care Team;Medicare;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;Morbidity - disease rate;mortality;multidisciplinary;New York;novel;Nurses;Nursing Services;Patient Care;Patient Discharge;patient home care;Patient-Focused Outcomes;Patients;Persons;Physicians;pilot test;Population;Positioning Attribute;post-doctoral training;Pragmatic clinical trial;preference;Prevalence;prevent;Process;Protocols documentation;Quality of life;Randomized, Controlled Trials;Research;Research Personnel;Resources;Self Efficacy;skills;Statistical Methods;Surveys;Tablets;Technology;Telephone;Testing;therapy design;therapy development;Time;tool;Training;Visiting Nurse;Work

PROJECT_TITLE: Leveraging Home Health Aides to Improve Outcomes in Heart Failure

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


NIH_SPENDING_CATS: Organ Transplantation;Transplantation

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative Acute allograft rejection is a T cell mediated immune response that continues to undermine treatment of end- stage organ disease through transplantation. The infiltration of endogenous memory T cells into allografts occurs early after reperfusion and the experiments proposed in this study will test the mechanisms of memory CD8 T cell activation to directly mediate increased graft tissue injury and rejection of cardiac allografts subjected to prolonged cold ischemic storage. The results should unveil new therapeutic targets for development of strategies to decrease this inflammation and inhibit acute graft injury and failure in recipients harboring high numbers of pre-existing memory CD8 T cells reactive to graft alloantigens.

PI_NAMEs: FAIRCHILD, ROBERT L (contact)

PROGRAM_OFFICER_NAME: KEHN, PATRICIA J

PROJECT_TERMS: Acute;Alloantigen;Allogenic;allograft rejection;Allografting;Antigens;Automobile Driving;Bacterial Infections;CD8-Positive T-Lymphocytes;Cell Adhesion Molecules;Cell Communication;cell mediated immune response;Cells;chemokine;Chronic;Clinical;Clinical Research;Cross Reactions;cytokine;delayed graft function;Dendritic Cells;Development;Disease;Elements;Endothelial Cells;Environment;Event;experimental study;Exposure to;Failure;Funding;Generations;Goals;graft failure;Graft Rejection;Graft Survival;Harvest;heart allograft;high risk;Histocompatibility Antigens Class I;Hour;Immune;Immunity;improved;improved outcome;Incidence;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Injury;insight;Interferons;Interleukin-6;Ischemia;Kidney Transplantation;Leukocytes;Mediating;Memory;memory CD4 T lymphocyte;Molecular;monocyte;mouse model;Mus;Natural Immunity;neutrophil;Neutrophil Infiltration;new therapeutic target;novel;Organ;Outcome;peripheral blood;Phase;post-transplant;Production;programs;Proliferating;Reperfusion Injury;Reperfusion Therapy;Research;Resistance;response;Role;Seminal;Signal Transduction;success;T cell infiltration;T cell response;T memory cell;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;Testing;Tissue Grafts;tissue injury;Tissues;Transplant Recipients;Transplantation;transplantation therapy;Virus Diseases

PROJECT_TITLE: Post-Transplant Inflammatory Response

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE Obesity and other weight-related problems, including poor dietary intake, inadequate physical activity, body dissatisfaction, and disordered eating behaviors, are of major public health concern, given their high prevalence and serious health consequences. Of particular concern is the high prevalence of these weight- related problems in adolescents and young adults from low-income and ethnic/racial minority groups in the United States. This longitudinal program of research will identify short- and long-term multi-level (individual, family, friend, school, worksite, and neighborhood) predictors of weight-related problems in young people and will guide the development of highly innovative and effective interventions to reduce the burden of these problems on marginalized populations.

PI_NAMEs: NEUMARK-SZTAINER, DIANNE R (contact)

PROGRAM_OFFICER_NAME: PRATT, CHARLOTTE A

PROJECT_TERMS: Address;Adolescent and Young Adult;Award;body dissatisfaction;Cohort Studies;Creativeness;Data Collection;Development;Dietary intake;Eating;Eating Behavior;Eating Disorders;effective intervention;Ensure;Environment;ethnic minority population;Etiology;Family;flexibility;follow-up;Friends;Future;Health;health difference;Health Professional;High Prevalence;Individual;innovation;interest;Life;Life Cycle Stages;Low income;Low Income Population;marginalized population;Mentors;Methods;Mission;Modeling;National Heart, Lung, and Blood Institute;Neighborhoods;next generation;Obesity;Outcome;Persons;Physical activity;Policies;Population;Population Heterogeneity;Population Intervention;prevent;Principal Investigator;Process;Productivity;programs;Public Health;racial minority population;Research;Research Personnel;response;Risk;Risk Taking;Sampling;Schools;Shapes;Strategic vision;Surveys;Teenagers;therapy development;tool;Training Programs;transition to adulthood;United States;Vision;Weight;Workplace;young adult

PROJECT_TITLE: Eating, Activity, and Weight-Related Problems Across the Life Course in Diverse Populations


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Immunotherapy;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Lymphoma is a cancer derived from lymphocytes, a type of white blood cell, with an annual mortality of over 20,000 patients in the United States. This research aims to uncover the key oncogenic signaling pathways that cancer cells gain addiction to in support of their survival and growth and to design corresponding treatment.

PI_NAMEs: RUI, LIXIN  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: acquired drug resistance;activated B cell like;addiction;Affect;Agammaglobulinaemia tyrosine kinase;Animal Model;antitumor effect;B-Cell Antigen Receptor;B-Lymphocytes;Binding Proteins;Bromodomain;cancer cell;Cancer Etiology;Cell Death;cell growth;Cell Line;Cells;ChIP-seq;Chromatin;Clinical;clinical investigation;Clustered Regularly Interspaced Short Palindromic Repeats;Data;design;Drug resistance;Drug Targeting;Engineering;EP300 gene;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic;genetic manipulation;Genetic Transcription;genome wide association study;Genomics;Growth;Hematology;Histones;Human;Immuno-Chemotherapy;In Vitro;in vivo;inhibitor;insight;interest;Interferon Inducers;Interferon Type I;Interferons;JAK1 gene;knock-down;large cell Diffuse non-Hodgkin's lymphoma;lenalidomide;leukemia;Leukocytes;lymph nodes;Lymphocyte;Lymphoma;Lymphoma cell;Malignant Neoplasms;Mediating;Molecular;molecular subtypes;mortality;mouse model;Multiple Myeloma;neoplastic cell;Newly Diagnosed;novel;novel marker;novel therapeutic intervention;Oncogenes;Oncogenic;overexpression;Pathway interactions;patient derived xenograft model;Patients;pharmacologic;preclinical study;Proliferating;Proteins;Reader;Refractory;Relapse;Research;Resistance;resistance mechanism;response;Role;Signal Pathway;Signal Transduction;small hairpin RNA;Solid;Stat3 Signaling Pathway;Structure of germinal center of lymph node;synergism;Testing;Therapeutic;therapeutically effective;Tonsil;Transcriptional Activation;transcriptome sequencing;transcriptomics;translational impact;treatment strategy;Tumor Suppressor Proteins;tumorigenesis;United States;Up-Regulation;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Targeting EGR1 signaling pathways in diffuse large B cell lymphoma

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE Improving human health will require improved understanding of human DNA, which has about 3 billion units that code for more than 20,000 different proteins (with many of these proteins existing in multiple forms) and for an undetermined number of regulatory molecules. Dealing with all of these entities and their interactions requires extensive use of computer algorithms. Exchanging information about the development and optimal use of these computational biology and bioinformatics algorithms is the focus of the Pacific Symposium on Biocomputing (PSB), which is one of the more significant scientific meetings on this topic.

PI_NAMEs: KLEIN, TERI ELLEN (contact)

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TITLE: Pacific Symposium on Biocomputing


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Genetics

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE RNA editing by adenosine deaminase that acts on RNA (ADAR1) helps control the cells inflammatory response by editing a unique RNA conformation, but at the cost of promoting viral infection and growth. The proposed research will gain a better understanding of how this unique conformation is recognized by ADAR1 at the molecular level. Using this knowledge, new treatment strategies can be designed in order to help fight viral infections.

PI_NAMEs: NICHOLS, PARKER J (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Adenosine;Adopted;alpha helix;Alu Elements;Amplifiers;Binding;Binding Sites;Biochemical;Biochemistry;biological adaptation to stress;Biological Process;biological research;Biophysics;Cells;Characteristics;conformational conversion;cost;Deaminase;design;Disease;DNA;Double-Stranded RNA Binding Domain;dsRNA adenosine deaminase;Event;experimental study;fighting;Foundations;Genetic Transcription;Growth;Helix-Turn-Helix Motifs;Human;Human Genome;IFIH1;Immune response;in vivo;Infection;Inflammatory Response;Innate Immune Response;Innate Immune System;Inosine;Interferons;Kinetics;Knowledge;Methods;Molecular;Molecular Conformation;mutant;Mutation;N-terminal;Nature;NMR Spectroscopy;novel therapeutic intervention;Pathway interactions;Play;Population;prevent;Primates;Proliferating;Protein Isoforms;Proteins;Research;Resolution;response;Retrotransposon;RNA;RNA Binding;RNA Conformation;RNA Editing;RNA Recognition Motif;Role;Side;Signal Transduction;Specificity;structural biology;Structure;synergism;Techniques;Testing;theories;Tissue-Specific Gene Expression;TLR3 gene;tool;transcriptome;transcriptome sequencing;Viral;Virus;Virus Diseases;West Nile;West Nile viral infection;Work;X-Ray Crystallography;Z-Form DNA

PROJECT_TITLE: A-Z junction formation drives recognition of Alu RNAs by ADAR1 and supports viral infectivity and replication


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Infectious Diseases

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: PROJECT NARRATIVE  Streptococcus gallolyticus subsp. gallolyticus (Sgg) is an opportunistic human pathogen that is implicated in life-threatening bacteremia, endocarditis and colorectal cancer. This proposal aims to investigate a novel mechanism that mediates Sgg adherence to the colonic epithelium.

PI_NAMEs: XU, YI  (contact)

PROJECT_TERMS: Address;Adherence;Affect;Affinity;Antibodies;Area;Bacteremia;biotypes;Cardiovascular system;Cell Proliferation;Cell Surface Receptors;Cells;Clinical;Colon;Colorectal Cancer;Data;Dependence;Development;diagnostic biomarker;Endocarditis;Engineering;Epidermal Growth Factor Receptor;Epithelial Cell Proliferation;Epithelial Cells;Epithelium;Future;gastrointestinal epithelium;Genetic;Goals;Growth Factor Receptors;gut colonization;Homeostasis;human pathogen;In Vitro;in vivo;Individual;Infective endocarditis;innovation;Intervention;knock-down;Knock-out;Knowledge;Life;Ligands;Link;Malignant Neoplasms;Mediating;Medical;microbial;Modeling;Molecular;novel;Organism;pathobiont;pathogen;Pathogenesis;Pathogenicity;Pathology;Phenotype;Play;prevent;Process;Protein Secretion;Proteins;Publishing;receptor;Receptor Cell;Recombinant Proteins;Regulation;Reporting;Research;Role;Streptococcus;Streptococcus bovis;Surface;System;Testing;Time;tool;translational potential;Variant;Virulence;Work

PROJECT_TITLE: Type VII secretion in Streptococcus gallolyticus adherence


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: NARRATIVE Enterococcus faecalis causes infections with high mortality. This research project will assess whether and how inhibitors of the enzyme carbonic anhydrase can work together with currently used antibiotics to inhibit the growth of E. faecalis. The results from the study will inform efforts to develop new therapies for E. faecalis infections.

PI_NAMEs: VAN TYNE, DARIA N (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acetazolamide;alternative treatment;Amino Acid Sequence;Aminoglycosides;Antibiotic Resistance;Antibiotics;Automobile Driving;bactericide;Biology;carbonate dehydratase;Carbonic Anhydrase Inhibitors;Cell Membrane Permeability;Chemicals;Clinical;combat;Combined Modality Therapy;Daptomycin;Data;Development;Endocarditis;Endophthalmitis;Enterococcus;Enterococcus faecalis;Enzyme Inhibitor Drugs;experimental study;Fatty Acids;FDA approved;Future;Gene Expression;genome sequencing;Genomics;Genotype;Gentamicins;Growth;healthcare-associated infections;Hospitals;improved;In Vitro;Infection;Infective endocarditis;inhibitor;insight;Laboratories;Linezolid;Measures;Membrane;Membrane Fluidity;Morbidity - disease rate;mortality;Multi-Drug Resistance;mutant;Mutation;new combination therapies;novel;novel therapeutics;opportunistic pathogen;Parents;pathogen;Patients;Permeability;Phenotype;Predisposition;Production;Proton-Motive Force;Research Project Grants;Resistance;Role;Streptomycin;Structure-Activity Relationship;synergism;Testing;Therapeutic;Time;treatment strategy;uptake;Vancomycin;Vulnerable Populations;whole genome;Work

PROJECT_TITLE: Carbonic anhydrase inhibition as a target for antibiotic synergy in enterococci

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DDR-C(01)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: PROJECT NARRATIVE In response to PAR-18-747, Addressing the Challenges of the Opioid Epidemic in Minority Health and Health Disparities Research in the U.S. (R01), we will analyze the role of culturally competent strategies, and in particular workforce diversity, in improving treatment access, engagement, and medication-assisted treatment (MAT) maintenance dosage, i.e., methadone, buprenorphine and naltrexone, for African-American and Hispanic populations in opioid treatment programs (OTP) nationwide.

PI_NAMEs: HOWARD, DANIEL L (contact)

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: access disparities;Address;Affect;African American;Aftercare;Buprenorphine;Characteristics;Client;Competence;cultural competence;Data;Data Set;Decision Making;Dependence;Disparity;disparity elimination;disparity reduction;dosage;Dose;Drug abuse;ethnic disparity;ethnic diversity;ethnic minority;ethnic minority population;evidence base;Health Disparities Research;Health Personnel;Health Services Accessibility;Hispanic;Hispanic Populations;Improve Access;improved;instrument;Knowledge;Linguistics;Link;Maintenance;Measurement;Measures;Medicaid;medication-assisted treatment;Methadone;Minority Groups;minority health;minority health disparity;minority patient;Modeling;Naltrexone;Opioid;opioid epidemic;opioid treatment program;opioid use disorder;Organizational Culture;payment;Pharmaceutical Preparations;Policy Maker;Process;Process Measure;Professional counselor;programs;Property;Psychometrics;Public Health;Quality of Care;Race;racial disparity;racial diversity;racial minority;racial minority population;Recording of previous events;Recovery;Research;Resources;Respondent;response;Role;Sampling;Services;social culture;Source;standard measure;Substance Use Disorder;substance use treatment;Surveys;System;Testing;theories;treatment disparity;Treatment outcome;treatment program;Variant;Wait Time;Woman;Work

PROJECT_TITLE: From Workforce Diversity to Key Cultural Competency Strategies to End Racial Disparities in Opioid Treatment Outcomes Across the Nation

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: WALTHAM

ORG_NAME: BRANDEIS UNIVERSITY

PHR: NARRATIVE This work will create a system to speed and improve genetic investigations of Aedes aegypti mosquitoes, a disease vector of both medical importance and basic science importance. Understanding Ae. aegypti biology provides insights into its development, physiology and behavior, and can inform control strategies, and improving approaches for genetic studies in Ae. aegypti will facilitate these efforts.

PI_NAMEs: GARRITY, PAUL  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Acceleration;Address;Adopted;Aedes;Afferent Neurons;Animals;Arboviruses;Basic Science;Behavior;Biological Process;Biology;Breeding;Cell Death;Cells;chikungunya;CRISPR/Cas technology;Culicidae;cytotoxicity;Dengue;design;Development;Disease;Disease Vectors;Drosophila genus;Drosophila melanogaster;Embryo;Essential Genes;experience;gene function;Gene Silencing;Gene Targeting;Genes;Genetic;genetic approach;Genetic study;genetic technology;Genetic Transcription;genome editing;Goals;Guide RNA;Health;Human;improved;Injections;Insecta;insight;interest;Investigation;Knock-in;Left;loss of function;Mediating;Medical;Methods;Modification;Molecular Genetics;Mosquito-borne infectious disease;mutant;neural circuit;Neurons;overexpression;Persons;Physiology;Population;Production;promoter;Research Personnel;Source;Specific qualifier value;Specificity;Speed;System;Testing;theories;tool;Transfer RNA;Transgenes;vector;vector control;vector mosquito;Virus;Work;Yellow Fever;ZIKA

PROJECT_TITLE: A Cell-specific modified CRISPR/Cas9 system for conditional gene disruption in Aedes aegypti

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-V(02)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: NEWARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: NEW JERSEY INSTITUTE OF TECHNOLOGY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Functional connectivity and functional networks of the brain’s cortical gray matter have allowed us to better understand how different regions of the human brain are connected. In this project we will investigate functional networks of the brain’s white matter, a critical region of the brain that is often overlooked in functional magnetic resonance imaging studies. Findings from this study will help to understand the brain as an integrated system of both white matter and gray matter and help to better diagnose and treat neuropsychiatric disorders.

PI_NAMEs: BISWAL, BHARAT BHUSAN (contact)

PROGRAM_OFFICER_NAME: BENNETT, YVONNE MARIE

PROJECT_TERMS: Address;Adult;advanced analytics;Affect;Affective;Age;age group;Algorithms;analytical tool;Anesthesia procedures;Applications Grants;Area;Atlases;blood oxygen level dependent;Brain;Brain Diseases;Brain region;brain volume;Characteristics;Clinical;Cognitive;cognitive function;cohort;Communities;Comprehension;connectome;Corpus Callosum;Data;Data Set;Development;Diagnosis;Diagnostic;Diffusion Magnetic Resonance Imaging;Dimensions;Disease;Disease Progression;experience;Foundations;Functional Magnetic Resonance Imaging;Future;Gender;Goals;Graph;gray matter;Growth;Human;imaging study;improved;Individual;Intelligence;Investigation;Knowledge;Light;Liquid substance;machine learning method;Magnetic Resonance Imaging;Maps;Measures;Mental disorders;Methods;Mining;Monitor;Motor;neglect;neuroimaging;Neurologic;neuropsychiatric disorder;Noise;Phenotype;Population;Process;Property;Reporting;Reproducibility;response;Rest;secondary analysis;Sensory;Series;Short-Term Memory;Signal Transduction;Sleep;Statistical Models;Systems Integration;Testing;Time;tool;trait;transmission process;United States National Institutes of Health;Validity and Reliability;vector;Vocabulary;white matter;Work

PROJECT_TITLE: Functional Connectivity and Baseline Networks of the White Matter Brain: Development and Dissemination of Algorithms and Tools

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]