NIH_SPENDING_CATS: Biotechnology;Cancer;Chronic Pain;Dental, Oral, and Craniofacial Disease;Immunotherapy;Neurosciences;Opioids;Orphan Drug;Pain Research;Palliative Care;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Immune checkpoint blockade is a promising therapeutic approach for head and neck cancer, however fewer than 20% of patients will respond to treatment. The proposed studies investigate the impact of opioids used for cancer pain management on the anti-tumor immune response and test the efficacy of peripheral opioid receptor antagonism to improve response to immunotherapy.

PI_NAMEs: SCHEFF, NICOLE N (contact)

PROGRAM_OFFICER_NAME: GHIM, MELISSA M

PROJECT_TERMS: Absence of pain sensation;Acute;Advanced Malignant Neoplasm;Affect;antagonist;anti-PD1 antibodies;anti-PD1 therapy;anti-tumor immune response;Binding;Biological Assay;Biopsy;Blood;Cancer Pain Management;Cancer Patient;cancer recurrence;cancer therapy;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Density;Cell Physiology;Cells;checkpoint therapy;Chemotaxis;cohort;Cohort Studies;Constipation;Coupled;cytokine;Data;Devices;disability;Disease;dosage;efficacy testing;Evaluation;exhaustion;experience;FDA approved;Flow Cytometry;Frequencies;Genes;Goals;GTP-Binding Proteins;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Histology;Human;IL2 gene;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immunologic Tests;Immunosuppression;Immunotherapy;Impairment;improved;improved outcome;In Vitro;in vitro Assay;in vivo;Infiltration;Institution;Knockout Mice;Leucocytic infiltrate;Malignant Neoplasms;Measures;Mediating;Melanoma;Metastatic/Recurrent;Monoclonal Antibody Therapy;Morphine;morphine administration;mouse model;mu opioid receptors;Mus;Muscle;Neoadjuvant Therapy;Nociception;Opioid;Opioid Antagonist;Opioid Receptor;opioid use;Oral;Oral cavity;orofacial;Pain;Pain management;pain relief;Palliative Care;Pathway interactions;Patients;Peripheral;Pharmaceutical Preparations;Phenotype;Population;pre-clinical;Pre-Clinical Model;prescription opioid;Production;programmed cell death protein 1;receptor expression;Receptor Signaling;Recurrence;Resistance;response;Signal Pathway;Signal Transduction;single-cell RNA sequencing;spectrograph;Survival Rate;survivorship;T cell infiltration;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Tissues;transcriptomics;Translating;Transplantation;treatment response;treatment strategy;tumor;tumor growth;Tumor Immunity;Tumor Tissue;Tumor-Infiltrating Lymphocytes;Xenograft procedure

PROJECT_TITLE: Overcoming Immunotherapy Resistance Through Opioid Antagonism in Head and Neck Cancer

STUDY_SECTION: TIR

STUDY_SECTION_NAME: Therapeutic Immune Regulation Study Section[TIR]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Patient Safety;Prevention;Women's Health Research

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on adopting a patient- priorities approach to decision making during survivorship care for older women with breast cancer and multiple chronic conditions. If shown to be feasible and acceptable to patients and clinicians, this approach maximizes benefits that matter to older women with breast cancer while minimizing harm and burden. This research is relevant to the NIA's mission because of its focus on care for older adults driven by patient's values, goals, and preferences, while supporting the further training of Dr. Giza to become a leader in geriatric oncology care.

PI_NAMEs: GIZA, DANA ELENA (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adopted;adverse outcome;Advocate;Applications Grants;Award;Behavioral Model;Breast Cancer survivor;Breast Cancer survivorship;Cancer Survivorship;cancer therapy;care preference;Caring;Clinic;Clinical;Clinical Trials Design;cognitive ability;Cohort Studies;comorbidity;Data;Decision Making;design;Development;Disease;effectiveness/implementation trial;Elderly;Elements;Enrollment;experience;Feedback;Financial Hardship;Future;Goals;Guidelines;Harm Reduction;Health;Health Priorities;Health Services;Health system;Healthcare;implementation strategy;improved;improved mobility;Interview;K-Series Research Career Programs;Learning;Life;Literature;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mediation;Medical;Medication Management;Methodology;Methods;Mission;Modeling;Modification;multiple chronic conditions;novel;older adult;older women;Oncologist;Oncology;Outcome;Patient Care Planning;Patient-Centered Care;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Physicians;Pilot Projects;Population;preference;primary outcome;Process;Provider;psychological distress;Public Health;Qualitative Methods;Quality of life;Quasi-experiment;Recommendation;Research;Research Personnel;routine care;secondary outcome;Service delivery model;skills;social engagement;Survivors;survivorship;Symptoms;therapy development;Training;Training Activity;treatment effect;treatment planning;Treatment-related toxicity;United States National Institutes of Health;user centered design;Visit;Woman;Work

PROJECT_TITLE: Patient Priorities Survivorship Care for Older Women with Breast Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-R (M1)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biomedical Imaging;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Precision Medicine;Prevention;Pulmonary Fibrosis

ORG_CITY: CHICAGO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Narrative COVID-19 pandemic has killed more than 6.9 million people and caused the worst healthcare crisis of this century. While over 765 million have recovered from COVID-19, the large portion of the population experiences persistent symptoms four weeks after their acute illness; this phenomenon is called post COVID-19, which is a long-term outcome associated with decreased lung function and major morbidity. A significant portion of patients who have suffered from COVID-19 are at risk for developing pulmonary fibrosis but there is no mechanism available to predict post COVID-19 pulmonary fibrosis at early stages. Therefore, the goal of this project is to develop and validate methods to predict patients at most risk for development of post COVID-19 pulmonary fibrosis with novel explainable deep learning algorithms on combined imaging and electronic health record (EHR) data from multiple centers.

PI_NAMEs: BAGCI, ULAS  (contact);JAMBAWALIKAR, SACHIN ;SALVATORE, MARY MARGARET

PROGRAM_OFFICER_NAME: CHARYA, ANANTH VELUGALETI

PROJECT_TERMS: Acute;Address;Adipose tissue;Adrenal Cortex Hormones;Affect;Algorithms;Area;Biological Markers;biomarker discovery;biomarker selection;Body Composition;Bone structure;capsule;care seeking;Cessation of life;Characteristics;chest computed tomography;Clinical;clinical center;clinical practice;combat;comorbidity;Confidence Intervals;COVID-19;COVID-19 pandemic;COVID-19 survivors;Data;Data Set;Databases;deep learning;deep learning algorithm;Detection;Development;Diagnosis;Diagnostic;Disease;Dyspnea;Early Diagnosis;Early identification;Early Intervention;Electronic Health Record;Emergency Situation;Evaluation;exhaust;Exhibits;experience;Factor Analysis;Fibrosis;fibrotic lung;follow-up;Future;Goals;Healthcare;Healthcare Systems;Human;Image;improved;Individual;individual patient;innovation;Knowledge;Laboratories;Long COVID;Long-Term Effects;Lung;lung injury;lung lobe;Lung Transplantation;Measurement;Methods;Modality;Modeling;Morbidity - disease rate;mortality;multimodal data;multimodality;Muscle;Musculoskeletal System;Neurocognitive;novel;Outcome;Patients;Pattern;Pennsylvania;persistent symptom;Personal Satisfaction;Persons;Pharmaceutical Preparations;Phase;Population;post-COVID pulmonary fibrosis;post-COVID-19;potential biomarker;Property;Public Health;Pulmonary Fibrosis;pulmonary function;pulmonary rehabilitation;pulmonary symptom;radiological imaging;Reporting;research clinical testing;respiratory challenge;Risk;risk prediction;SARS-CoV-2 infection;Scanning;severe COVID-19;Severity of illness;Skeletal Muscle;standard of care;statistics;subcutaneous;success;Symptoms;Testing;Texture;Therapeutic;Thick;tool;Training;Translations;treatment strategy;United States National Institutes of Health;Universities;Vaccination;Variant;Ventilator Weaning;Visceral;Visual;Work;X-Ray Computed Tomography

PROJECT_TITLE: Predicting Post-Covid Pulmonary Fibrosis with Explainable Deep Learning and Optimal Biomarker Discovery

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: American Indian or Alaska Native;Chronic Pain;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Racial and Ethnic Minority Health Research;Substance Misuse

ORG_CITY: BANGOR

ORG_NAME: WABANAKI HEALTH AND WELLNESS

ORG_STATE: ME

PI_NAMEs: CAMMACK, RALPH  (contact)

PROGRAM_OFFICER_NAME: HAFNER, STEVEN PAUL

PROJECT_TERMS: Aborigine;Acceleration;Acute Pain;Address;Administrator;American;Area;behavioral health;care providers;Caring;Child;chronic pain;Clinical Research;Communities;community based research;community collaboration;Community Health Education;Computer software;Data;data management;Databases;Dedications;design;Development;Educational Curriculum;electronic data;Electronics;Emergency medical service;empowerment;Ensure;Epidemic;experience;Focus Groups;Funding;Grant;handheld mobile device;Health;Health Insurance Portability and Accountability Act;Health Services;Helping to End Addiction Long-term;Houlton;House Staffs;Human Resources;improved;Indigenous;Individual;informant;Infrastructure;Institutional Review Boards;Interview;Language;Light;literacy;Maine;member;Methods;Online Systems;Opiate Addiction;opioid misuse;opioid use disorder;Overdose;Pain;pain scale;Passamaquoddy;Penobscot;Personal Satisfaction;Persons;Phase;Play;Privacy;Process;Provider;Public Health;Quality Control;Recovery;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;research study;Research Training;Rights;Role;rural area;Safety;Secure;Self Determination;skills;Speed;stimulant use disorder;substance misuse;support network;Surveys;Testing;tool;Training;Trauma;Tribes;Trust;United States National Institutes of Health;Universities;Washington;web based software;Work

PROJECT_TITLE: Understanding Pain Expression in Wabanaki People during Recovery: Enhancing Wabanaki Research, Data Self-Determination, and Capacity Development

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 OTHR-6 (01)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Genetic Testing;Genetics;Health Services;Pediatric;Prevention

ORG_CITY: BRONX

ORG_DEPT: PEDIATRICS

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE ScreenPlus is a comprehensive, fluid, pilot newborn screening program that will screen at least 100,000 consented infants for specific disorders in order to determine disease incidence in a diverse population while defining the analytic and clinical validity of multi-tiered, multiplexed screening assays. Longitudinal clinical data will be collected from infants identified through the program in order to provide evidence about the potential benefit of NBS on outcome, while also documenting the natural history of pre-symptomatic disease. Finally, the ethical, legal, and social issues associated with expanded newborn screening will be explored.

PI_NAMEs: WASSERSTEIN, MELISSA PITTEL (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Affect;Anniversary;assay development;Biological Assay;Biological Markers;Birth Rate;Blood;Child;Climacteric;Clinical;Clinical Data;Clinical Trials;Collection;Communities;Complex;Consent;Contracts;Cost Sharing;Country;Data;data sharing;Databases;Decision Making;design;Development;Diagnosis;Disease;Disease Progression;disease registry;Dryness;Early Diagnosis;Early treatment;Education;Effectiveness;Equity;ethical, legal, and social implication;Ethicists;Ethics;fascinate;flexibility;Focus Groups;follow-up;Funding;Future;Goals;Hospitals;Incidence;Industry;Infant;infant monitoring;Informed Consent;Infrastructure;innovation;insight;Interview;Laboratories;Lead;Learning;Life;Liquid substance;Longterm Follow-up;Methods;Monitor;Natural History;Neonatal Screening;New York;novel;Outcome;Parents;patient advocacy group;Performance;Pharmacologic Substance;Population Heterogeneity;Process;Productivity;programs;Public Health;public trust;Rare Diseases;recruit;Resources;Risk;routine screening;screening;screening panel;screening policy;screening program;Series;Signs and Symptoms;social;sound;Spottings;Surveys;Technology;Testing;Time;treatment response;trend;United States;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: NY ScreenPlus: A Comprehensive, Flexible, Multi-disorder Newborn Screening Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-C (02)]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Heart disease is the leading cause of death and a major cause of morbidity in the United States and other developed countries. Disorders of cardiac rhythmicity comprise a significant proportion of this disease burden. Our research is designed to more fully uncover the mechanisms that lead to cardiac rhythm disorders and identify potential new strategies for therapeutic intervention.

PI_NAMEs: FISHMAN, GLENN I (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Arrhythmia;Binding Sites;Biological Models;burden of illness;Cardiac;Cardiac conduction system;cardiac resynchronization therapy;Cardiomyopathies;Cardiovascular Diseases;Cardiovascular system;Cause of Death;Cell Separation;Cells;Collagen Gene;conditional knockout;Critical Pathways;Data;Data Set;design;Developed Countries;Development;Devices;Diabetes Mellitus;Disease;Down-Regulation;Exposure to;Fibroblasts;Functional disorder;Funding;Gene Expression Profiling;Gene Targeting;Genes;Genetic;Genetic Transcription;Genetically Engineered Mouse;Heart;Heart Block;Heart Diseases;Heart failure;heart rhythm;hemodynamics;Heritability;human induced pluripotent stem cells;human stem cells;Hypertension;Implantable Defibrillators;implantable device;In Vitro;in vivo;innovation;Interleukin-1 beta;Knockout Mice;Knowledge;Laboratories;Ligands;Macrophage;Modality;Molecular;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;Muscle Cells;Myocardial;Myocardial Ischemia;Neuregulins;new therapeutic target;novel;novel therapeutic intervention;Obesity;Pacemakers;Paracrine Communication;Pathologic;Pathway interactions;Patients;Periodicity;periostin;Play;prevent;programs;Purkinje Cells;Reporter;Repression;Research;Research Personnel;response;Role;Signal Pathway;Signal Transduction;Signaling Molecule;stem cell model;Stress;stressor;Structure;sudden cardiac death;Syndrome;System;Systems Development;targeted agent;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Time;tool;transcription factor;transcriptional reprogramming;Transforming Growth Factor beta;United States;United States National Institutes of Health;Up-Regulation;Ventricular;Ventricular Remodeling;Visualization;Work

PROJECT_TITLE: Mechanisms of Purkinje Cell Remodeling

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Enrollment in Medicare Advantage, the managed care alternative to Traditional Medicare, covers nearly half of Medicare beneficiaries and disproportionately enrolls minorities and low-income beneficiaries. Managed care could improve the care of patients with Alzheimer's Disease and Related Dementias (ADRD) through care coordination and supplemental benefits, though regulators have raised concerns about inappropriate denials of care relative to Traditional Medicare. This project considers whether Medicare Advantage impacts potentially preventable hospitalizations, discharges without home or facility based care, transitions across sites of care, racial, ethnic, and income disparities in care, and intergenerational transfers of time and money among Medicare beneficiaries with ADRD and their families.

PI_NAMEs: NICHOLAS, LAUREN HERSCH (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Abnormal coordination;access disparities;Alzheimer's disease patient;Alzheimer's disease related dementia;beneficiary;Black race;care burden;care coordination;caregiving;Caring;Case Manager;Cessation of life;Characteristics;Child;Code;cohort;Complex;Computer software;Conflict (Psychology);cost;Data;Decision Making;Dementia;dementia care;design;Disparity;dual eligible;Education;Enrollment;ethnic disparity;ethnic minority;Ethnic Origin;experience;Family;Family member;flexibility;Friends;Generations;grandchild;Grant;Health;Health and Retirement Study;health care disparity;health care service utilization;health disparity;Healthcare;high school;Home;hospice environment;Hospitalization;Household;Housing;improved;Incentives;Income;income disparities;informal care;informal caregiver;intergenerational;Intergenerational transfer;Life;Low income;Managed Care;Medicaid eligibility;Medicare;Minority;Minority Enrollment;nursing skill;Outcome;palliative;Palliative Care;Patient Care;patient home care;Patients;payment;Persons;Policy Maker;posthospitalization care;preference;Race;racial disparity;racial minority;Reporting;Research;Resources;satisfaction;Services;Site;social;social health determinants;socioeconomic disparity;Surveys;Time;tool;Translating;United States Dept. of Health and Human Services;Well in self;Work

PROJECT_TITLE: Care for Persons with Dementia in Medicare Advantage and Traditional Medicare: Family Spillovers and Disparities

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-8 (M4)]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Networking and Information Technology R&D (NITRD)

ORG_CITY: STANFORD

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: MRI receiver array performance is paramount to achieve fast high-quality images yet it is encumbered by low-tech bulky cable interfaces which themselves can interact negatively with the array and patient workflow. We will cut the cord and demonstrate the entire ecosystem and supporting technology for wireless MRI receive arrays. Wireless MRI technology will enable open interfaces and vendor agnostic deployment on any scanner.

PI_NAMEs: PAULY, JOHN M. (contact)

PROGRAM_OFFICER_NAME: WANG, SHUMIN

PROJECT_TITLE: Wireless MRI Receive Arrays: Incorporating UWB Data Links and Vitals Sensing

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE The future generation of cancer health disparities scholars will need training in conceptual and methodological issues to conduct high impact research that advances equity in disease risk and outcomes. The ADVANCE CHDR will use a comprehensive approach to enhance the knowledge, skill, and capacity of predoctoral students in minority health, cancer health disparities research, and community engagement among students in the Department of Population and Public Health Sciences at the University of Southern California.

PI_NAMEs: HUGHES-HALBERT, CHANITA A.;STERN, MARIANA C (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Advanced Malignant Neoplasm;Health Disparities Research;Training Programs

PROJECT_TITLE: ADVANCE Cancer Health Disparities Research (CHDR) Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-N (51)]


ADMINISTERING_IC: AT

ED_INST_TYPE: SCHOOLS OF CHIROPRACTIC

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Back Pain;Chronic Pain;Clinical Research;Complementary and Integrative Health;Disability Research;Health Services;Pain Research;Patient Safety

ORG_CITY: WHITTIER

ORG_DEPT: MISCELLANEOUS

ORG_NAME: SOUTHERN CALIFORNIA UNIV OF HEALTH SCIS

PHR: NARRATIVE  The proposed research is germane to public health because it is expected to employ health system relevant outcome measures to assess the impact of the decision by Medicare to cover a guideline-concordant non-pharmacologic treatment for chronic low back pain. The project is relevant to the mission of the National Center for Complementary and Integrative Health because it will evaluate a complementary and integrative healthcare intervention for management of Medicare patients with chronic low back pain, a population that tends to be comorbid, difficult to manage, and at risk for adverse effects of pharmacologic interventions. This project is expected to foster interdisciplinary collaborations and partnerships as it produces new evidence for the non-pharmacologic management of chronic low back pain.

PI_NAMEs: MACKENZIE, TODD A.;WHEDON, JAMES M. (contact)

PROGRAM_OFFICER_NAME: JEAN-FRANCOIS, BEDA

PROJECT_TERMS: Acupuncture Therapy;Address;Adoption;Adverse effects;aged;Area;Attitude;Belief;beneficiary;care costs;care outcomes;Caring;Chronic Care;Chronic low back pain;Clinical;cohort;comorbidity;Complementary Health;cost;Cross-Sectional Studies;Crystallization;Data;design;disability;Ensure;Equity;Evaluation Research;evidence base;Focus Groups;Fostering;Future;Guidelines;Health Care Costs;Health Services Accessibility;Health system;Healthcare;high risk;Immersion;Improve Access;improved;Integrative Medicine;interdisciplinary collaboration;Interruption;Intervention;Knowledge;Logistics;Measures;Medical;Medicare;Medicare claim;Mission;National Center for Complementary and Integrative Health;Nonpharmacologic Therapy;Opioid Analgesics;Outcome;Outcome Measure;Patient Care;patient population;Patient-Focused Outcomes;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Policies;Population;prescription pain reliever;Provider;Public Health;Quality of Care;Recommendation;Research;Risk;Safety;Series;Serious Adverse Event;Services;Societies;Specific qualifier value;statistics;Testing;Text;Time;Transcript;trend;United States Centers for Medicare and Medicaid Services;Variant;Vertebral column

PROJECT_TITLE: Acupuncture for Medicare Beneficiaries with Chronic Low Back Pain: Access, Utilization, and Outcomes

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Aging;Clinical Research;Digestive Diseases;Dissemination and Implementation Research;Health Services;Palliative Care;Patient Safety

ORG_CITY: ROCHESTER

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: The frail older adult (OA) population is growing rapidly, are high utilizers of surgical services, and has unique risks and considerations in surgical shared decision-making (SDM). Improvement of the surgical SDM process is needed to ensure goal concordant surgical care, particularly prior to high risk major colorectal surgery.

PI_NAMEs: POLES, GABRIELA  (contact)

PROJECT_TERMS: Address;Age;Aging;aging population;aging related;American College of Surgeons;career;Caring;Client satisfaction;Clinical;cognitive function;Colorectal Surgery;Communication;Communities;comorbidity;Complex;Consolidated Framework for Implementation Research;Critical Care;Decision Making;Development Plans;Elderly;Electronics;Enrollment;Ensure;Ethics;expectation;experience;Family;Frail Elderly;frailty;functional decline;Geriatrics;Goals;Health;Health Care Costs;high risk;human old age (65+);Impaired cognition;implementation outcomes;improved;improved outcome;indexing;individualized medicine;instrument;Interview;Intestines;Medical;Methodology;Nature;older adult;Operative Surgical Procedures;Outcome;Palliative Care;Participant;Patient Compliance;patient oriented;patient population;Patient Representative;Patient-Centered Care;Patients;Physical Function;pilot test;Population;Postoperative Period;Process;prognostic;programs;Provider;Public Health;Quality of Care;Quality of life;recruit;Research;Research Personnel;Risk;Risk Assessment;Sex Functioning;shared decision making;Site;standard of care;Structure;Surgeon;Surgical complication;surgical risk;surgical service;Testing;tool;treatment planning;United States;urinary;user-friendly;Work

PROJECT_TITLE: Exploring Best Communication Practices for Shared Decision Making in Older Adults Considering Major Colorectal Surgery


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Lewy Body Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BALTIMORE

ORG_DEPT: GENETICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: We will study how individually mild mutations, acting within regulatory genomic sequences, act to influence the risk and progression of common genetic diseases. Here, we propose to define potential regulatory sequences in neurons that are preferentially affected in Parkinson disease (PD), evaluating how the use of different subsets of regulatory sequences are altered by age and disease-causing, experimental treatments. We will use this information to study (computationally and experimentally) the identity, DNA sequence, and biological necessity of gene control regions, as well as the impact of mutations that may disrupt them in disease – illuminating how they contribute to the molecular mechanisms underlying PD risk and progression.

PI_NAMEs: MCCALLION, ANDREW S (contact)

PROGRAM_OFFICER_NAME: SWANSON-FISCHER, CHRISTINE R

PROJECT_TERMS: Address;Affect;Age;age related changes;alpha synuclein;ATAC-seq;Bioinformatics;Biological;Biological Assay;Biology;Catalogs;Cell Nucleus;Cell Survival;cell type;Cells;ChIP-seq;Chromatin;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Complement;Conserved Sequence;Data;Dementia;Diffuse Lewy Body Disease;Disease;Disease Progression;Disease susceptibility;disease-causing mutation;disorder risk;DNA;DNA Sequence;dopaminergic neuron;encryption;Enhancers;Exposure to;falls;Gaucher Disease;Gene Expression;Gene Expression Profile;Genes;genetic analysis;Genetic Diseases;Genetic Transcription;genome wide association study;genome-wide analysis;genomic data;Genomics;Homeostasis;Human;Human Genetics;Human Genome;human induced pluripotent stem cells;Impaired cognition;improved;in vitro Assay;Individual;Induced pluripotent stem cell derived human neuron;Instruction;Investigation;Lewy Body Dementia;Lifting;Link;Linkage Disequilibrium;Machine Learning;machine learning classifier;Maps;Midbrain structure;Mitochondria;Modeling;Molecular;Mus;Mutation;Nervous System Disorder;Neurons;novel;Ontology;Orthologous Gene;Parkinson Disease;Pathway Analysis;patient derived induced pluripotent stem cells;Patients;Phenotype;Population;postnatal;pre-formed fibril;Pregnancy;promoter;Prosencephalon;Publishing;Reporter;response;Risk;risk prediction;risk variant;sequence learning;Stress;Testing;Time;tool;Toxic effect;Training;transcription factor;transcriptome sequencing;transcriptomics;Untranslated RNA;Variant;Vocabulary

PROJECT_TITLE: Systematic investigation of disease-associated, regulatory variation; illuminating their prediction, molecular consequences and mechanisms contributing to risk of Parkinson disease (PD)

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Project Narrative  Heart failure is a leading cause of death worldwide. Pathological cardiac remodeling in response to hypertension induces the activation of Rps6kb1 in cardiomyocytes, of which precise roles and mechanisms-of- action are elusive. Experiments laid out here will focus on two novel post-translational modifications of Rps6kb1 in pressure overload-induced cardiomyopathy and heart failure, which may provide new insights for our understanding of hypertensive heart disease and shed light on novel therapeutic approaches.

PI_NAMEs: WANG, ZHAO  (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: Acceleration;Acute;Address;Animal Model;aorta constriction;Applications Grants;Biological Assay;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cause of Death;Clinical;combat;Complement;Complex;conditional knockout;Data;design;Development;Evaluation;experimental study;FRAP1 gene;gain of function;Goals;Growth;Heart;Heart failure;Heart Hypertrophy;Hypertension;hypertensive heart disease;Hypertrophy;Immunoprecipitation;Impairment;In Vitro;in vivo;insight;interest;knock-down;Knock-in Mouse;Knockout Mice;Knowledge;loss of function;Lysine;Mass Spectrum Analysis;Mediating;Modification;Molecular;Morbidity - disease rate;mortality;mouse model;multidisciplinary;Mutagenesis;Mutation;novel;novel therapeutic intervention;Outcome;Pathologic;Pathway interactions;Patients;phosphoproteomics;Phosphorylation;Phosphorylation Site;Phosphotransferases;pilot test;Play;Polyubiquitination;Post-Translational Protein Processing;pressure;Process;Protein Biosynthesis;Proteins;Reaction;Reporting;Research;response;Ribosomal Protein S6 Kinase;Risk Factors;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Site;Stress;Testing;Therapeutic Intervention;therapeutic target;therapeutically effective;Threonine Phosphorylation Site;TRAF6 gene;ubiquitin-protein ligase;Ubiquitination;Ventricular

PROJECT_TITLE: Integrative role of Rps6kb1 in pathological cardiac remodeling

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Comparative Effectiveness Research;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Health behavior interventions introduced into social networks have the potential to efficiently improve population health by benefitting not just intervention recipients, but also those influenced by intervention recipients. However, the complex dynamics of social networks make it hard to predict the types of networks and network interventions where this approach will be most impactful, particularly for adults in midlife whose social networks are understudied. The current project will use simulation analyses based on real-world data from a workplace social network to identify the intervention strategies and network characteristics that yield the most positive, equitable, and cost-effective impact on health behavior outcomes for midlife adults.

PI_NAMEs: LEVY, DOUGLAS  (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Adult;Affect;Age;Behavior Therapy;Behavioral;Calibration;cardiometabolism;Characteristics;Complex;Computer Models;cost;cost effective;cost effectiveness;Cost efficiency;Data;Data Set;density;design;Diet;disability;Diverse Workforce;Employee;Equity;Ethnic Origin;Feedback;Food;Gender;Health;Health behavior;Health behavior and outcomes;Health Benefit;Healthy Eating;Heterogeneity;Hospitals;improved;incremental cost-effectiveness;Individual;Intervention;intervention cost;intervention effect;Life Expectancy;Literature;Maps;Measures;Mediating;middle age;Modeling;modifiable risk;neglect;network models;Obesity;Occupations;Outcome;Pathway Analysis;Pathway interactions;peer;peer influence;Persuasive Communication;Population;population health;Race;randomized trial;Research;Risk Factors;Running;segregation;Shapes;simulation;social;Social Behavior;social influence;Social Network;social network intervention;social norm;sociodemographic disparity;sociodemographics;socioeconomics;Structure;success;Testing;Time;transmission process;Work;Workplace

PROJECT_TITLE: Simulation Analyses to Optimize Workplace Social Network Interventions for Improving Health Behaviors in Midlife

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-L (A1)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Rural Health;Social Determinants of Health

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: This study is about understanding how environmental stress plays a role in the risk of developing Alzheimer’s disease and related dementias. We focus on comparing the experiences of people living in cities versus those in rural areas in Indiana, USA, using a mobile app and smartwatch to track their daily stressors and health data. The goal is to identify specific environmental factors that might contribute to Alzheimer’s and related dementias.

PI_NAMEs: JORDAN, EVAN  (contact)

PROGRAM_OFFICER_NAME: DHRUV, NEEL TUSHAR

PROJECT_TERMS: Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;American;assessment application;Cities;cognitive testing;coping;Crime;Custom;Data;Data Collection;Data Set;Dementia;Development;Diagnosis;Digital biomarker;Ecological momentary assessment;Electronic Health Record;Elements;Eligibility Determination;Enrollment;Environment;Environmental Risk Factor;environmental stressor;experience;Exposure to;Funding;Goals;Green space;health data;health disparity;health inequalities;Healthcare;Heart Rate;high risk;high risk population;human old age (65+);Image;Indiana;Individual;Inequity;Intervention;Jordan;Knowledge;land use;Learning;Location;Measurement;Measures;Methods;mild cognitive impairment;mobile application;Modeling;Monitor;Noise;novel;older adult;Outcome;Paper;Participant;participant enrollment;Patient Self-Report;Persons;Play;Pollution;Process;programs;recruit;Reporting;Research;Research Personnel;Resources;response;Risk;Role;Rural;rural area;rural dwellers;rural environment;Rural Population;rural residence;Science;Severities;Sleep;smart watch;spatiotemporal;Stress;stressor;Testing;Text;therapeutic target;Time;transportation access;urban dwelling;Urban Population;urban setting;wearable sensor technology;Workplace

PROJECT_TITLE: Assessing Urban-Rural Environmental Stress Inequities in ADRD through Ecological Momentary Assessment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-K (55)]


ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative: There is a critical need to better understand the development of resistance to targeted therapies and to identify new targets for treatment of metastatic prostate cancer. As an integral member of the laboratory of Dr. Joshua Lang, Dr. Jamie Sperger has developed novel liquid biopsy assays aimed at tackling these questions and they are now using these tools to monitor the emergence of resistance in prostate cancer to improve our understanding of cancer, develop new therapeutic interventions and supporting biomarker development.

PI_NAMEs: SPERGER, JAMIE M (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: advanced prostate cancer;Androgen Receptor;AR gene;assay development;Biological Assay;Biological Markers;biomarker development;Cells;Clinical Trials;Complex;DNA Sequence Alteration;Epigenetic Process;experience;Funding;Gene Rearrangement;improved;inhibitor;Laboratories;Lead;liquid biopsy;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;member;men;Metastatic Prostate Cancer;Methods;Microfluidics;Molecular;Monitor;Mutation;next generation;novel;novel therapeutic intervention;Patients;pharmacologic;Phase;Publications;Qualifying;Receptor Signaling;Regulation;Resistance;Resistance development;targeted treatment;Technology;Therapeutic;tool;Translating

PROJECT_TITLE: The next generation of liquid biopsies: Predictive and pharmacologic biomarkers

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-1 (M2)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Substance Misuse

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE Alcohol-associated liver disease (ALD), caused by excessive alcohol consumption, is a cause of rising liver- related mortality in the United States, yet we lack even one approved therapy. We propose an innovative platform to explore fundamental aspects of ALD pathogenies, the contribution of gut endotoxins, and understand how a genetic risk factor influences disease development and progression. These studies will provide new insights to inform development of effective diagnostics and treatments that can improve the lives of both patients and those at risk.

PI_NAMEs: WU, XIANFANG  (contact)

PROGRAM_OFFICER_NAME: MURRAY, GARY

PROJECT_TERMS: 3-Dimensional;Address;Alcohol consumption;alcohol exposure;Alcoholic Liver Diseases;Alcohols;Animal Model;Automobile Driving;Blood alcohol level measurement;Cell Communication;cell type;Cells;clinically relevant;comparative;Comprehension;Consensus;Development;Diagnostic;diagnostic value;Disease;disease phenotype;Disease susceptibility;disorder prevention;disorder risk;Down-Regulation;Drug Targeting;Endotoxins;Ethanol;Ethanol Metabolism;Exhibits;experimental study;FDA approved;Fortification;Gene Expression Regulation;Genes;Genetic;genetic risk factor;genetic variant;Genetic Variation;Goals;Health;Heavy Drinking;Hepatic;Hepatic Stellate Cell;Hepatocyte;hepatocyte injury;Human;human induced pluripotent stem cells;improved;In Vitro;in vitro Model;individual response;Inflammatory;Inflammatory Response;Inherited;innovation;insight;Intestinal permeability;Investigation;Knowledge;Laboratories;Leaky Gut;Link;Liver;Liver diseases;Macrophage;Mediating;Metabolic;migration;Modeling;Molecular;mortality;Mutagenesis;Names;Nature;neutrophil;Organ;Oxidative Stress;Pathogenesis;Pathway interactions;Patients;Phenotype;Physiology;Play;Population;Populations at Risk;Predisposition;Prevention strategy;Public Health;Reaction;Research;response;Risk;Role;Severities;Site;spheroids;stem cell biomarkers;stem cell model;Stimulus;Study models;System;Testing;Therapeutic Intervention;therapeutic target;therapeutically effective;Time;Tissues;transcriptomics;Transforming Growth Factor beta;United States;Up-Regulation;Variant

PROJECT_TITLE: Studying alcohol-associated liver disease and its interaction with rs738409 variant in PNPLA3 in a liver culture model

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Aging;Genetics;Prevention

ORG_DEPT: BIOLOGY

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Narrative Biomarkers can provide us with powerful tools for the prediction, diagnosis, prognosis, and ultimately prevention, of age-related diseases. Until now we have lacked good model systems to understand the mechanisms behind so-called “biological clocks”, which have become very popular biomarkers of aging. Using the fruit fly as a powerful experimental system, we develop a new kind of biological clock based on measures of metabolites— the molecular building blocks found in all species—and use this novel clock to better understand aging.

PI_NAMEs: PROMISLOW, DANIEL EDWARD (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Affect;Age;age related;age-related disease;Aging;aging biomarker;aging clocks;aging mechanism;aging process;aging related;aging related disease;Agreement;anti aging;Automobile Driving;biological age;Biological Clocks;Biological Markers;Biological Models;Blood specimen;Callithrix;Cessation of life;cohort;Cytosine;Data;Diagnosis;Dietary Intervention;DNA;DNA Methylation;Drosophila genus;Drug Screening;Environmental Risk Factor;epigenetic clock;Epigenetic Process;Exhibits;Experimental Models;flexibility;fly;Foundations;Future;gene therapy;Generations;Genetic;genetic manipulation;Genetic Screening;Genotype;geroprotector;Goals;Health;healthspan;high-throughput drug screening;Histamine;Histidine;Human;improved;Individual;Inheritance Patterns;Inherited;innovation;Intervention;Intervention Studies;Invertebrates;Life;Life Expectancy;life span;Link;Longevity;Measures;Metabolic Pathway;Metabolism;metabolome;metabolomics;Methods;Methylation;methylome;microbiome;model organism;Modeling;Molecular;molecular domain;Morbidity - disease rate;mortality;Mus;next generation;non-genetic;novel;Organism;Outcome;Pattern;Pharmaceutical Preparations;Physical Fitness;Play;Population;precision medicine;predictive tools;Prevention;Prognosis;Publishing;Research;Research Personnel;Resistance;Resources;response;Risk Factors;Role;sex;Shapes;small molecule;Stress;Study models;success;Supplementation;Surrogate Markers;System;Testing;Tissues;tool;trait;translational applications;translational model;translational potential;Variant;Work;Yeasts

PROJECT_TITLE: Metabolomics clocks as a tool to explore mechanisms of aging

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Data Science;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE Therapy development for Alzheimer's disease has been impeded by significant disease heterogeneity. Our objective is to reveal and stratify heterogeneous AD populations into clinically targetable groups using completed clinical trial/registries data. If successful, this project will speed up clinical trials by informing the design of future intervention trials.

PI_NAMEs: JIANG, XIAOQIAN ;KIM, YEJIN  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Acceleration;Address;Aducanumab;Alzheimer's Disease;Alzheimer's disease patient;arm;Big Data;Biological Markers;Cause of Death;cerebral atrophy;Characteristics;Clinical;Clinical Pathways;clinical subtypes;Clinical Trials;clinically actionable;Complex;Data;data harmonization;data integration;data registry;Data Set;demographics;design;Development;disease heterogeneity;Disease Progression;disorder subtype;diverse data;drug development;effective therapy;Effectiveness;Ensure;experience;Future;Generations;Goals;Heterogeneity;Impaired cognition;Individual;individual response;individualized prevention;Informatics;innovation;Intervention;Intervention Trial;Knowledge;Learning;Liquid substance;Machine Learning;machine learning model;mild cognitive impairment;Modeling;Monitor;multimodality;neuropathology;novel;novel therapeutics;Outcome;patient population;patient subsets;Patient-Focused Outcomes;Patients;Pattern;personalized medicine;Pharmaceutical Preparations;Phase;Placebos;Population;Prevention strategy;primary outcome;Process;racial population;randomized trial;randomized, clinical trials;Recommendation;Reproducibility;Research;Resolution;Risk;Risk Factors;simulation;Source;Speed;Stratification;Structure;targeted treatment;tau Proteins;therapeutic development;therapy development;Therapy trial;treatment effect;treatment response

PROJECT_TITLE: Data-driven Subtypes of Alzheimer's disease progression for targeted treatment


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Contraception/Reproduction;Mental Health;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: NARRATIVE  This longitudinal study aims to determine the temporal relationship between concussion and persistent psychological problems in adolescent concussion and further examine if changes in pubertal hormones and/or MRI abnormalities detected in midline brain regions within the first week of injury or three months later mediate this relationship.  Such findings have the potential to move a step toward the identification of objective targets for future research in personalized intervention strategies, designed to modulate hormone-dependent mechanisms of brain plasticity in a sensitive period, and therefore more likely to be effective in reducing the psychiatric morbidity of concussed adolescents later in life.

PI_NAMEs: KONTOS, ANTHONY P;VERSACE, AMELIA  (contact)

PROGRAM_OFFICER_NAME: ZEHR, JULIA L

PROJECT_TERMS: 18 year old;Adolescence;Adolescent;Adult;Affect;Age;Animal Model;Animals;Anterior;Anxiety;Area;Biomechanics;Body mass index;boys;Brain;Brain Concussion;Brain Injuries;Brain region;Child;Chronic;Chronic Phase;Clinical;Cognitive;Complex;concussive symptom;dehydroepiandrosterone;density;Depressed mood;design;Detection;Development;Developmental Process;Early identification;Early treatment;emotion dysregulation;emotion regulation;Emotions;Endogenous Factors;Estradiol;Ethnic Origin;Exogenous Factors;Forcep;Future;girls;healing;Health Status;Hormonal;Hormonal Change;Hormones;Human;Hypopituitarism;Hypothalamic structure;Image;Impairment;improved;indexing;Injury;innovation;Intervention;Interview;Knowledge;Lesion;Life;Limbic System;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Mediating;Menarche;Menstruation;Mental Health;Methods;Minor;Modeling;Morbidity - disease rate;neural correlate;Neurites;neuroimaging;Outcome;Ovulation;Participant;Patient Self-Report;personalized intervention;Pituitary Gland;prospective;protective effect;psychologic;psychological symptom;Puberty;Public Health;Race;Recording of previous events;Recovery;recruit;Regulation;Reporting;Reproductive Physiology;Risk;Risk Factors;Role;saliva sample;Sampling;Scanning;Secondary to;Severities;sex;Sex Differences;Statistical Methods;Structure;Symptoms;Testing;Testosterone;theories;Thinness;Time;white matter

PROJECT_TITLE: identifying Concussed Adolescents at Risk for Emotional dysregulation 2 (iCARE2)

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Aging;Cardiovascular;Genetics;Heart Disease;Human Genome;Lung;Sleep Research

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: PROJECT NARRATIVE The physiological and molecular mechanisms of Obstructive Sleep Apnea (OSA)-induced vascular senescence leading to vascular dysfunction remain to be elucidated. Transgenic mouse models enable the detection and selective ablation of cells expressing p16, a known marker of cellular senescence. These models will be exposed to Intermittent Hypoxia and Sleep Fragmentation to investigate aorta and coronary artery function, epigenetic age acceleration and molecular alterations induced by OSA in cardiovascular dysfunction.

PI_NAMEs: CORTESE, RENE GABRIEL (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Ablation;accelerated epigenetic aging;Acceleration;Adult;Affect;Age;age acceleration;aging related disease;aging reversal;airway obstruction;Aorta;Arousal;Arrhythmia;Arteries;Atherosclerosis;Attenuated;biological age;bisulfite sequencing;Blood;Blood Pressure;Blood Vessels;Body System;Breeding;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Cell Aging;Cell division;Cells;Chronic;Chronology;comparison control;Continuous Positive Airway Pressure;Coronary Arteriosclerosis;Coronary artery;Cyclin-Dependent Kinase Inhibitor 2A;Data;Detection;diphtheria toxin receptor;DNA Methylation;Endothelial Cells;endothelial dysfunction;Endothelium;Epidemiology;epigenetic aging;epigenetic clock;epigenome;Evaluation;Event;Exposure to;Functional disorder;Gene Expression Profiling;Heart failure;Human;human disease;Hypercapnia;Hypertension;Hypoxia;improved;in vivo;Inflammatory;innovation;Intervention;Link;Measurement;Mediating;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;novel;novel strategies;Obesity;Obstructive Sleep Apnea;Outcome;Oxidative Stress;Pathway interactions;patient variability;Patients;Persons;Phenotype;Physiologic pulse;Physiological;Prediction of Response to Therapy;pressure;Prognostic Marker;Proteins;quantification of aging;Recurrence;Reporter;RNA;Role;senescence;senescent cell;Sleep;Sleep Apnea Syndromes;Sleep Fragmentations;Stroke;targeted treatment;therapeutic development;therapeutic target;Time;Tissues;transcriptome;transcriptome sequencing;Transgenic Mice;Up-Regulation;vascular bed;Vascular Diseases;Vascular Endothelial Cell;virtual;whole genome

PROJECT_TITLE: p16 Cellular Senescence and Vascular Dysfunction in Sleep Apnea

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Pediatric;Pediatric Cardiomyopathy;Rare Diseases

ORG_CITY: SEATTLE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Newly identified findings that disabling cardiac fibroblast by p38 deficiency corrects the dilated cardiomyopathy (DCM) phenotype in mice expressing a sarcomeric variant demonstrates fibroblasts play an unequivocal role in early-stage DCM pathogenesis. In the DCM setting cardiac fibroblasts adaptively responded to the sarcomeric variant by proliferating but failed to undergo canonical activated state transitions, which resulted in myocardial anisotropy and stiffness albeit without conventional fibrosis. Understanding the underlying determinants of adaptive cardiac fibroblast responses, what mechanical property of the heart the fibroblast response is trying to correct, and whether therapies for inherited DCM will need to target fibroblast-dependent processes is vital to overcoming current limitations with standard-of-care and first-in-class muscle cell-specific interventions.

PI_NAMEs: DAVIS, JENNIFER MICHELLE (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Address;Adult;Age;Anisotropy;Behavior;Cardiac;Cardiac Myocytes;cardiac tissue engineering;Cell Cycle;Clinical;Collagen;Collagen Fiber;Complication;Contracts;coronary fibrosis;Data;Defect;Development;Dilated Cardiomyopathy;directed attention;Disabling;Disease;Disease Progression;Effectiveness;effectiveness evaluation;Esthesia;Excision;Extracellular Matrix;familial dilated cardiomyopathy;Fibroblasts;Fibrosis;Fluorescence Resonance Energy Transfer;Focal Adhesions;Functional disorder;gene therapy;Generations;Genes;Genetic;Heart;Heart Block;Heart failure;improved;Inherited;Intervention;Left;Link;Measures;mechanical properties;mechanotransduction;Mediating;Modeling;Molecular;mouse model;Mus;Muscle Cells;Mutation;Myocardial;Myocardium;Myosin ATPase;Outcome;p38 Mitogen Activated Protein Kinase;Pathogenesis;Pathologic;periostin;Pharmacologic Substance;Phase;Phenotype;Play;Population;postnatal;postnatal development;Precision therapeutics;Predisposition;Prevalence;prevent;Process;Proliferating;Property;Reporter;Repression;Resolution;response;Role;Sarcomeres;Severities;standard of care;Sterile coverings;Stress;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Tissues;Transgenic Mice;Tropomyosin;Troponin C;Variant;Ventricular Remodeling;Work

PROJECT_TITLE: Uncovering The Mechanogenomic Basis For Cardiac Plasticity


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Clinical Research;Comparative Effectiveness Research;Health Services;Physical Injury - Accidents and Adverse Effects

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: NARRATIVE Despite tremendous progress in improving the quality of orthopaedic trauma research over the past decades, poor outcomes remain unacceptably common in this patient population. The adaptive platform trial design has emerged as a highly efficient alternative to the conventional randomized clinical trial design, allowing multiple interventions to be simultaneously compared with sample sizes adapted to yield clinically actionable inferences. We propose an 18-month planning period to support the pre-trial simulations, document development, and trial structure to initiate a comparative effectiveness adaptive platform trial aimed at improving patient-important outcomes of patients 65 years or older with a lower extremity fracture.

PI_NAMEs: O'HARA, NATHAN NOEL (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: acetabulum;Admission activity;American;Area;Automobile Driving;Cessation of life;Clinical;clinical care;clinical decision-making;clinical practice;Clinical Research;Clinical Trials;Clinical Trials Design;clinically actionable;cohort;Communities;comparative;comparative effectiveness;comparison intervention;Computer Simulation;Contracts;COVID-19 pandemic;Data;design;Development;Distal;effective therapy;Effectiveness of Interventions;Ensure;experience;Femoral Fractures;flexibility;forging;Fostering;Fracture;Funding;Futility;Goals;Grant;Health system;Home;improved;Infrastructure;Intervention;Knowledge;Learning;Lower Extremity Fracture;Mentorship;Modeling;Multicenter Trials;Musculoskeletal;Nail plate;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Nature;Operative Surgical Procedures;Orthopedics;Outcome;patient population;Patient-Focused Outcomes;Patients;Pelvis;Population;Process;Protocols documentation;Randomized;randomized trial;randomized, clinical trials;Recovery of Function;Research;Research Personnel;Resources;Sample Size;Series;simulation;Site;Specific qualifier value;Statistical Data Interpretation;Structure;study population;Subgroup;Surgeon;Testing;Therapeutic;Time;Trauma patient;Trauma Research;treatment effect;trial design;trial planning

PROJECT_TITLE: Musculoskeletal Adaptive Platform Trial (MAPT)

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Biotechnology;Genetics;Neurosciences

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative For this project will investigate a family of three genes known as TMEM63s which are important for hearing, neuronal develop, blood and kidney function. Genetic disorders in this gene family cause dysfunction in all four systems. We aim to determine the structure and function of TMEM63 proteins with particular focus on TMEM63B and its role in hearing.

PI_NAMEs: HOLT, JEFFREY R (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Acoustic Stimulation;adeno-associated viral vector;Animals;Auditory;Bathing;Biochemical;Biological;Biological Assay;Blood;Brain;Caenorhabditis elegans;Calcium;Calcium-Activated Potassium Channel;Cell Death;Cell Line;Cell membrane;Cell Survival;Cells;Cochlea;Cryoelectron Microscopy;Data;deafness;dimer;Disease;DNA Sequence Alteration;Electrophysiology (science);Environment;epileptic encephalopathies;experimental study;Family;Family member;Functional disorder;Gene Family;Genes;Genetic;Genetic Diseases;Genomics;Goals;Hair Cells;Health;Hearing;hearing impairment;Hematology;Human;human disease;hypertensive;IL2 gene;In Vitro;in vivo;Inherited;Inner Hair Cells;insight;interest;Investigation;Ion Channel;Ions;Knock-in Mouse;Knockout Mice;Lead;leukodystrophy;Measures;mechanical force;Mechanical Stimulation;Mechanics;member;Molecular;monomer;Mus;mutant;Mutation;Myelin;myelination;Neurodevelopmental Disorder;neuron development;Neurons;novel;Osmolar Concentration;Osmosis;Outer Hair Cells;particle;Pathologic;Pathway interactions;Patients;Perfusion;Physiological;Plants;Potassium;pressure;Protein Region;Proteins;proteoliposomes;Protocols documentation;Publishing;Rattus;renal damage;Renal function;Reporting;Role;Series;Site-Directed Mutagenesis;Structure;Swelling;Symptoms;System;Testing;Tissues;Transfection;Variant;Work

PROJECT_TITLE: Structure and Function of Mechanosensitive Channels in Inner Ear Hair Cells

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PHR: PROJECT NARRATIVE This project addresses critical fiscal and administrative barriers to substantially strengthen the infrastructure and impact of the SENSE Network, an international, collaborative scientific group that is a nexus for scientific interaction and interdisciplinary collaborations in sensory aging, a field connecting sensory health and gerontology, including the influence of sensory health on Alzheimer’s disease and related dementias (ADRD). The data, research and dissemination infrastructure created as part of this project will foster diversity, increase the pace of innovation and discovery, facilitate the development of interventions, and catalyze translation of innovative research to clinical care and policy. By accelerating and potentiating the impact of siloed researchers, data sets, and projects, the SENSE Network is poised to take a leading role in the field of sensory aging research, advancing science of aging through in-depth interdisciplinary partnerships and collaborations to positively impact the health of older adults in the U.S. and globally.

PI_NAMEs: DEAL, JENNIFER ANNE (contact);EHRLICH, JOSHUA ROBERT

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Acceleration;Address;Aging;Alzheimer's disease related dementia;Area;Award;Behavioral;Binding;career;Clinical;clinical care;clinical practice;Cohort Studies;Collaborations;computerized;Congresses;Consensus;Consultations;Data;Data Collection;data harmonization;data infrastructure;Data Linkages;data repository;data resource;Data Set;design;Development;disability;Economics;Ensure;experience;Fostering;functional independence;Funding;Future;Geographic Factor;Geriatrics;Gerontology;Goals;Grant;Growth;Health;health data;Individual;Infrastructure;infrastructure development;innovation;Institution;interdisciplinary collaboration;interest;International;Knowledge;late life;Leadership;Lived experience;Measurable;Measures;meetings;Mentorship;Methodology;multiple datasets;National Archive;Network Infrastructure;novel;older adult;Online Systems;outreach;Personal Satisfaction;Phase;Pilot Projects;Policies;Population;Protocols documentation;Research;research and development;Research Infrastructure;Research Personnel;research study;Resources;Role;Science;Sensory;Services;social;success;symposium;therapy design;therapy development;Time;Training Activity;Translating;Translations;web site

PROJECT_TITLE: Sensory Aging, Late-Life Wellbeing, and ADRD Research Infrastructure to Catalyze Practice and Policy

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-3 (M3)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: MONTREAL

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: CENTRE DE RECHERCHE DE L'HOPITAL DOUGLAS

ORG_STATE: PQ

ORG_ZIPCODE: H4H 1R3

PHR: The proposed research will significantly advance our understanding of the cellular and molecular pathways, and cell-specific transcriptomic profiles contributing to the neurobiological basis of major depressive disorder. Through a better understanding of the mechanisms of depressive illness, we may be one step closer to developing novel treatment strategies and personalize interventions. The proposed project will be representative of both Caucasians and African American individuals and will be sufficiently powered to identify molecular processes that are sex specific.

PI_NAMEs: TURECKI, GUSTAVO  (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Address;Affect;African American;African American population;Amygdaloid structure;Anterior;anti-depressive agents;Area;association cortex;Autopsy;Biological;Biological Assay;Bipolar Disorder;Brain;brain cell;Brain region;burden of illness;caucasian American;Cell Nucleus;cell type;Cells;Chromosome Mapping;cingulate cortex;cognitive function;cohort;convolutional neural network;Data;deep learning;depressive symptoms;Diagnostic;Disease;Disease remission;Emotional;Emotions;Etiology;European;Female;Functional disorder;functional genomics;Gatekeeping;Gene Expression;gene network;Gene set enrichment analysis;Genes;Genetic;Genetic Transcription;genome wide association study;genome-wide;genomic locus;Genomics;Hippocampus;Human;Human Resources;Impairment;Individual;innovation;Investigation;Ligands;Link;Machine Learning;Major Depressive Disorder;Maps;Mediating;Mental Depression;Mental disorders;Metabolic;Modeling;Molecular;Mood Disorders;mood regulation;Moods;Morbidity - disease rate;multi-ethnic;negative mood;Negative Valence;Network-based;neural network;Neurobiology;Neurosciences;novel;Outcome;Pathway interactions;personalized intervention;Play;Process;Protocols documentation;Psychopathology;Pyramidal Cells;Quantitative Genetics;Quantitative Trait Loci;receptor;Research;Research Domain Criteria;Resolution;Resources;response;Role;Sample Size;Sampling;Series;sex;Sexual Dysfunction;single episode major depressive disorder;single nucleus RNA-sequencing;Structure;Suicide;Techniques;transcriptome;transcriptomics;treatment strategy;Work

PROJECT_TITLE: 2/2 Large-scale, single-cell characterization of molecular and cellular networks of mood regulation circuitry in major depressive disorder

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative On average, rural Americans die younger and spend more of their lives in poor health than their urban peers – disparities that have been growing for the past 40 years. However, rural places are not all the same, and while some rural areas face significant challenges related to living long and healthy lives, others are thriving and may offer lessons that can improve health and longevity in struggling rural communities. The Interdisciplinary Network on Rural Population Health and Aging (INRPHA) brings together scholars from multiple disciplines, institutions, and topical interests to advance knowledge on the complex factors affecting the health and wellbeing of rural working-age and older adults through various activities, including: regular meetings, workshops, and working groups; pilot grants to stimulate new research; mentoring of junior scholars; and dissemination of findings to academic, policy, and public audiences through presentations, academic publications, public research briefs, and more.

PI_NAMEs: HENNING-SMITH, CARRIE E (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: Academic support;Affect;Age;Aging;aging population;Automobile Driving;Chronic;climate change;Collaborations;Colorado;Communities;Complex;coping;COVID-19;Data;data resource;Data Set;design;Development;Dimensions;Discipline;Disparity;disparity reduction;Economics;Educational workshop;Environment;Environmental Health;Ethnic Origin;ethnoracial;Exhibits;Face;Fostering;Foundations;Funding;Grant;Growth;Health;health difference;health disparity;Heterogeneity;Home;improved;improved outcome;Industry;Infrastructure;innovation;Institution;inter-institutional;interest;Knowledge;Lead;Learning;Left;Life Cycle Stages;Longevity;meetings;member;Mentors;Methodology;Minnesota;Mississippi;mortality;Natural Disasters;novel;novel strategies;older adult;Out-Migrations;Outcome;Pattern;peer;Personal Satisfaction;Persons;Policies;Population;Population Group;population health;Poverty;programs;Public Health;Publications;Race;Research;Research Support;resilience;Resources;Rural;rural America;rural Americans;rural area;Rural Community;rural disparities;Rural Health;Rural Population;rural setting;rurality;Scholarship;Services;Shock;social;socioeconomics;stressor;Structure;success;Training;training opportunity;trend;Unemployment;United States National Institutes of Health;Universities;urban disparity;Variant;web site;webinar;Work;working group

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-9 (M2)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Rural Health;Social Determinants of Health;Substance Misuse;Wound Healing and Care

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

ORG_STATE: NC

PHR: PROJECT NARRATIVE The proposed mixed-methods study will investigate the growing crisis of injection-related wounds and skin and soft tissue infections among people who inject drugs (PWID) in the Appalachian foothills of North Carolina. Knowledge gained from this study will help identify xylazine prevalence in the Illicit drug supply and characterize the etiology and unique features of novel and severe wounds and other IWSSTIs by Drug, Set, and Setting (DSS) risk factors. Because the sharp growth in both xylazine exposure and IWSSTIs among PWID comprise an emerging health crisis, these data are time sensitive, and the proposed study is poised to make a timely and effective contribution to public health response.

PI_NAMEs: ZIBBELL, JON ERIC (contact)

PROGRAM_OFFICER_NAME: CREAMER, MELISA RAY

PROJECT_TERMS: Abscess;Address;Amputation;Animals;Ankle;antinociception;Appalachian Region;Appearance;Behavior;Behavioral;Caring;Case Study;Centers for Disease Control and Prevention (U.S.);Characteristics;Chemical Burns;Chronic;chronic ulcer;Clinical;Clinical Research;Communicable Diseases;Communities;Consensus;Consumption;County;COVID-19;Data;Data Collection;Dermal;Dermatologic;Development;disorder risk;Drug Contamination;Environment;Epidemiologist;Ethnography;Etiology;Exhibits;experience;Exposure to;Fentanyl;fentanyl overdose;fentanyl test;Fingers;follow-up;Food;Functional disorder;Funding;Future;Gangrene;Growth;Guidelines;Health;Homelessness;Hospitalization;Hospitals;Illicit Drugs;Incidence;Infection;Infectious Skin Diseases;Injecting drug user;injection drug use;Injections;Interview;Investigation;Irritants;Knee;Knowledge;Left;Letters;Link;Longitudinal cohort;Longitudinal Studies;Medicaid;Medical;Methods;Modeling;Morbidity - disease rate;National Institute of Drug Abuse;Nature;Necrosis;North Carolina;novel;overdose death;Panniculitis;Participant;Persons;Pharmaceutical Preparations;Physicians;Pilot Projects;Poison;Policies;Prevalence;Principal Investigator;Property;Psychologist;Public Health;Reaction;recruit;Reporting;Research;research study;Respondent;response;Risk;Risk Factors;Risk Marker;Sampling;Scientist;Sedation procedure;septic;Severities;Site;Skin Nodule;Skin Tissue;skin ulcer;social stigma;Soft Tissue Infections;Source;Stress;Surgical complication;Surveys;synthetic drug;System;test strip;Time;Toes;Toxic effect;Tranquilizing Agents;Typology;United States;United States National Institutes of Health;wound;wound care;Wound Infection;Xylazine

PROJECT_TITLE: A Growing Crisis of Novel Injection-Related Wounds and Skin & Soft Tissue Infections among People Who Inject Drugs: A Community-Based, Longitudinal Investigation in North Carolina

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Opioids;Pain Research;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Substance Misuse

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

PI_NAMEs: ECHO-HAWK, ABIGAIL ;MCDONELL, MICHAEL G (contact);RASMUS, STACY M.;VENNER, KAMILLA L.

PROGRAM_OFFICER_NAME: HAFNER, STEVEN PAUL

PROJECT_TERMS: Acceleration;addiction;Address;Alaska;Alaska Native;Alaska Native population;Alcohol consumption;alcohol risk;alcohol use disorder;Alcohols;Ally;American Indian Population;American Indian Tribe;American Indians;Belief;chronic pain;Collaborations;college;Colonialism;Communication;Communities;community based participatory research;community center;community engagement;community research;comorbidity;Computer software;Consultations;contingency management;Country;culturally appropriate intervention;Data;data framework;data quality;Decision Making;design;Elderly;Epidemiology;Evaluation;evidence base;Evidence based intervention;experience;Family;Feedback;Foundations;Frequencies;Funding;Future;German population;Goals;Grant;Growth;Harm Reduction;Harvest;healing;Health;Health Benefit;Helping to End Addiction Long-term;improved;Indigenous;Individual;Infrastructure;innovation;interest;intertribal;Intervention;Intervention Studies;Knowledge;Lead;Leadership;Learning;learning community;Letters;life span;medication for opioid use disorder;Medicine;meetings;member;Mental Health;Mentors;Metaphor;methamphetamine use;Methamphetamine use disorder;Methods;mid-career faculty;Modeling;motivational enhancement therapy;Native American Research Center for Health;Native Americans;Native-Born;Needs Assessment;New Mexico;non-Native;Opioid;opioid epidemic;opioid use;opioid use disorder;Outcome;Outcome Assessment;Pacific Northwest;Pain;Pain management;Personal Satisfaction;Persons;Pharmaceutical Preparations;Phase;Plants;Policies;Positioning Attribute;preference;Preparation;Prevention;Prevention approach;Principal Investigator;Process;Productivity;professor;protective factors;Protocols documentation;Psychological reinforcement;Publications;Publishing;Readiness;Recording of previous events;Recovery;Rejuvenation;Reporting;Research;research data dissemination;Research Design;Research Infrastructure;Research Personnel;Research Priority;Research Support;Research Training;Resources;response;Rural;Science;screening and brief intervention;Seasons;Self Determination;Shoshone Indians;special interest group;Stimulant;stimulant use;Students;substance use;success;suicidal risk;Suicide;support tools;Techniques;Telephone;tool;Training;training opportunity;Trauma;tribal community;Tribally Based Participatory Research;Tribes;United States National Institutes of Health;Universities;Urban Community;urban Native American;Visual;Washington;web site;Wellness Program;Work;Writing;Youth

PROJECT_TITLE: Promoting Community Wellbeing Through Indigenous Science and Healing

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 OTHR-6 (01)]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Depression;Electronic Nicotine Delivery Systems;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: STILLWATER

ORG_DEPT: PSYCHOLOGY

ORG_NAME: OKLAHOMA STATE UNIVERSITY STILLWATER

ORG_STATE: OK

PHR: PROJECT NARRATIVE While almost 40% of children in the US are exposed to harmful environmental tobacco smoke, which is associated with poorer pediatric mental health outcomes, rising poly-use of combustible cigarettes, electronic nicotine delivery systems (ENDS) and combustible cannabis products among reproductive-aged adults could be intensifying environmental harms posed to pediatric mental health. Despite evolving risks, minimal data exists on the combined impact of these environmental smoke and vapor exposures across child development. To inform interventions and policies safeguarding children, this study will describe how cumulative exposure to emissions from combustible tobacco, ENDS, and combustible cannabis products from the prenatal period to adolescence shapes mental health trajectories.

PI_NAMEs: APPLESETH, HANNAH  (contact)

PROGRAM_OFFICER_NAME: MASH, CLAY

PROJECT_TERMS: Accounting;Address;Adolescence;Adult;Affect;Age;aged;Anxiety;Attention deficit hyperactivity disorder;Behavior;Biological Assay;Biometry;Black race;Blood;Cannabis;carcinogenicity;career;Characteristics;Child;Child Behavior Checklist;Child Development;Child Health;Child Mental Health;Childhood;Cigarette;cigarette smoking;combustible cigarette;combustible tobacco;Complex;Confounding Factors (Epidemiology);Cotinine;Data;Data Set;design;Development;Dimensions;disadvantaged background;Disparity;early childhood;Electronic Nicotine Delivery Systems;Environmental Exposure;Environmental Health;Environmental Impact;environmental tobacco smoke;Exhibits;experience;Exposure to;Face;Family member;follow-up;Funding;Goals;Grant;hazard;health inequalities;high risk;high risk population;Hispanic;Housing;Hyperactivity;Individual;infancy;innovation;Intervention;lens;longitudinal dataset;low socioeconomic status;marginalized population;marijuana smoke;Marijuana Smoking;Measurement;Measures;Mental Depression;Mental Health;Mental Health Associations;middle age;middle childhood;Modeling;Nervousness;Nicotine;nicotine exposure;nicotine vapor;Not Hispanic or Latino;Outcome;Parents;Participant;Patient Self-Report;Pattern;Pediatric cohort;Policies;post pregnancy;Pregnancy;Pregnant Women;prenatal;Prevalence;Prevention;primary caregiver;programs;Psychological Stress;Public Health;Reporting;reproductive;Research;Risk;Sampling;Shapes;Smoke;Smoking;smoking cessation;sociodemographics;Socioeconomic Status;Specific qualifier value;Stress;Subgroup;substance use;Symptoms;Time;tobacco exposure;toxicant;Toxicant exposure;Training;Translating;trend;United States National Institutes of Health;vaping;vapor;Woman

PROJECT_TITLE: Tracing the Impact of Evolving Environmental Exposure to Tobacco, Cannabis, and Nicotine Smoke and Vapor Emissions on Children's Mental Health Symptom Trajectories

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EPH-F (50)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: The proposed studies will examine the role of the innate immune system in the development and/or exacerbation of salt-sensitive hypertension. The studies will specifically address the role of myeloid cyclooxygenase-2/PGE2 in mediation of alterations of effector T cells, in mediation of altered responses to a high salt diet. The studies will determine alterations in sodium handling by the kidney and investigate potential mechanisms by which macrophage and/or dendritic cells mediate alterations in T cell responses to a high salt diet.

PI_NAMEs: HARRIS, RAYMOND C. (contact);ZHANG, MINGZHI

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: absorption;Adaptive Immune System;Address;Affect;Arachidonic Acids;Blood;Blood Pressure;blood pressure elevation;Bone Marrow;Cell Physiology;Cells;cyclooxygenase 2;Dendritic Cells;Development;dietary salt;Dinoprostone;effector T cell;Epidemiology;Equilibrium;Essential Hypertension;Etiology;hemodynamics;high salt diet;Hypertension;Immune;Immunomodulators;Individual;Infiltration;Inflammatory;Innate Immune System;Kidney;kidney cell;Link;Macrophage;Mature Lymphocyte;Mediating;Mediation;Mediator;Morbidity - disease rate;mortality;mosaic;Mus;Myelogenous;Myeloid Cells;normotensive;novel;Pathogenesis;PD-1/PD-L1;Phenotype;Production;programmed cell death ligand 1;programmed cell death protein 1;Prostaglandin E Receptor;Prostaglandin-Endoperoxide Synthase;Prostaglandins;Protein Isoforms;Regulation;response;Risk;Role;salt sensitive hypertension;Sodium;Sodium Chloride;Source;System;Systemic blood pressure;Systemic hypertension;T cell regulation;T cell response;T-Cell Activation;T-Lymphocyte;Transplantation;Water;WFDC2 gene;Wild Type Mouse

PROJECT_TITLE: The role of the innate immune cell cyclooxygenase/prostaglandin system in blood pressureregulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-V (03)]


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: NARRATIVE Our ultimate goal is to develop a practical (translational), theranostic platform for managing prostate cancer. We will leverage our expertise with prostate-specific membrane antigen (PSMA) and in the development of multi-functional dendrimers for imaging and therapy. A key innovation is the addition of magnetic resonance imaging, a clinically ubiquitous modality, using chemical exchange saturation transfer (CEST) – avoiding potential toxicity due to gadolinium administration – for pharmacokinetic analysis of our agents and therapeutic monitoring.

PI_NAMEs: LESNIAK, WOJCIECH ;MCMAHON, MICHAEL T;POMPER, MARTIN G (contact)

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: Affinity;American Cancer Society;Amines;Antibody-drug conjugates;Antigen Targeting;Antimitotic Agents;Binding;Biodistribution;Cancer Etiology;Cell Line;Cessation of life;chelation;Chemicals;Clinical;clinical translation;Clinical Trials;clinically relevant;cytotoxicity;Data;Death Rate;Deferoxamine;delivery vehicle;Dendrimers;Development;Disease;Dose;Drug Delivery Systems;Drug Kinetics;Encapsulated;Evaluation;experience;flu;FOLH1 gene;Formulation;Frequencies;Gadolinium;Generations;Glutamates;Goals;Histologic;Human;Image;image guided;imaging modality;imaging platform;Immunotherapeutic agent;improved;In Vitro;innovation;Ligands;Link;Lysine;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Maximum Tolerated Dose;Measures;men;Metastatic Prostate Cancer;Modality;Monitor;mouse model;multimodality;Mus;nanotheranostics;Neoplasm Metastasis;non-invasive monitor;novel therapeutics;optical imaging;Outcome;Patient Selection;Patients;PC3 cell line;Pharmaceutical Preparations;Positioning Attribute;Positron-Emission Tomography;pre-clinical;Property;Prostate Cancer therapy;Radioactivity;Radiolabeled;Radionuclide Imaging;Salicylic Acids;Screening for Prostate Cancer;Series;Signal Transduction;subcutaneous;targeted imaging;targeted radiotherapeutic;targeted treatment;Testing;theranostics;Therapeutic;Therapeutic Effect;Therapeutic Studies;time interval;Tissues;tool;Toxic effect;toxic metal;Treatment Efficacy;trend;tumor;United States;Urea;X-Ray Computed Tomography;Xenograft procedure

PROJECT_TITLE: Multimodal dendrimer theranostics targeting aggressive subtypes of prostate cancer

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: This proposed study is aligned with the Human Resources and Service Administration’s Ending the HIV Epidemic proposal to reduce HIV incidence by 75% in 5 years and 90% in 10 years. The objective of this study is to adapt a previously developed mHealth platform to improve the successful use of pre-exposure prophylaxis (PrEP) for HIV among Black adolescents and young adults living in both rural and urban areas within the Alabama by strengthening social support from trusted adults. Success of this mHealth platform also has the potential to build support systems that further empower adolescents and young adults with HIV prevention.

PI_NAMEs: HILL, SAMANTHA V (contact)

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: 21 year old;acceptability and feasibility;Address;Adherence;adherence rate;Adolescent and Young Adult;Adolescent Medicine;Adult;Affect;Age;AIDS prevention;Alabama;Attitude;Award;behavior change;Behavior Therapy;Behavioral;behavioral health intervention;Behavioral Sciences;Bisexual;black men who have sex with men;Black Populations;Black race;career;Clinical;Clinical Trials;Collaborations;Communication;Communities;community advisory board;community building;community collaboration;community partners;community partnership;Data;Deep South;design;Development;Disease;Disparity;disparity reduction;Dose;education resources;Electronics;Eligibility Determination;empowerment;Ensure;Epidemic;Ethics;experience;experimental study;Foundations;Funding;Future;Gays;Geography;girls;Goals;Health;Health behavior;health disparity;Healthcare;Heterosexuals;HIV;HIV diagnosis;HIV Infections;Human Resources;improved;Incidence;Individual;Infection;instrument;interest;Intervention;Interview;K-Series Research Career Programs;Knowledge;Lived experience;male;Mentors;Mentorship;Methods;mHealth;Mobile Health Application;Modification;Names;National Institute of Drug Abuse;Oral;Outcome;Parents;patient oriented;Patient Self-Report;pediatric human immunodeficiency virus;Persons;Physicians;pill;Pilot Projects;Population;Positioning Attribute;pre-exposure prophylaxis;prevent;Process;Provider;Publishing;Regimen;Research;Risk;risk perception;Rural;rural area;Rural Community;rural counties;Schedule;Self Efficacy;Services;sex;sexual and reproductive health;Sexual Health;skill acquisition;skills;social cognitive theory;Social Environment;Social Network;social norm;social stigma;Social support;success;Support System;Surveys;Technology;tool;Training;transgender men;transgender women;Trust;United States;United States Dept. of Health and Human Services;United States National Institutes of Health;urban area;virtual;Visit;vulnerable adolescent;Vulnerable Populations;Work;young woman

PROJECT_TITLE: Integration of Trusted Adult Supports into the HealthMpowerment App to Improve Black Adolescent and Young Adult PrEP Use

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative: Latina adolescents report high rates of inactivity and are at especially high lifetime risk for diabetes, obesity, and other lifestyle-related conditions. The proposed study seeks to adapt an existing physical activity intervention for Latina girls, Chicas Fuertes, and test its effectiveness and implementation potential as an external referral program for Federally Qualified Health Centers. It will build a foundation for broad implementation, using existing clinical systems and widespread technologies to shift health behaviors across the life course and promote health equity.

PI_NAMEs: LARSEN, BRITTA  (contact)

PROGRAM_OFFICER_NAME: SHIROMA, ERIC JITSUO

PROJECT_TERMS: Academy;Accelerometer;Address;Adherence;Adolescence;Adolescent;Adoption;Adult;Age;American;Back;Behavior;biomedical referral center;Blood Pressure;Body mass index;boys;Childhood;Clinic;Clinical;Communities;community organizations;Comparison arm;comparison group;contextual factors;cost efficient;Counseling;County;Data;data sharing;design;diabetes risk;Disparity;Documentation;Drops;Educational workshop;Effectiveness;effectiveness evaluation;effectiveness/implementation trial;Electronic Health Record;Environment;ethnic minority;evidence based guidelines;exercise intervention;Family health status;Federally Qualified Health Center;Female Adolescents;fitbit;Foundations;Future;girls;Guideline Adherence;Guidelines;Habits;Health;Health behavior;health equity promotion;Health Personnel;Health Promotion;Health Technology;high risk;Hybrids;implementation determinants;implementation evaluation;implementation outcomes;improved;Individual;Infrastructure;innovation;Instagram;Internet;Intervention;intervention delivery;Intervention Studies;Interview;Knowledge;Latina;Latina Population;Latino;Latino Population;Life;Life Cycle Stages;lifestyle factors;Lifestyle-related condition;lifetime risk;Maintenance;Male Adolescents;Measures;meetings;Mental Depression;Mental Health;metabolic rate;Metabolic syndrome;Methods;mHealth;mobile computing;moderate-to-vigorous physical activity;Monitor;National Heart, Lung, and Blood Institute;Obesity;Overweight;Patient Compliance;Patients;Pattern;Pediatrics;Perception;Physical activity;physical conditioning;pilot trial;Practical Robust Implementation and Sustainability Model;Prevention;Primary Care;programs;Provider;racial minority;Randomized;Recommendation;Regimen;remote delivery;Reporting;Research;Resource-limited setting;Resources;Role;Running;Sampling;scale up;social determinants;structural health determinants;System;tailored text messaging;Technology;Teenagers;Testing;theories;Time;tool;Training;Visit;wearable data;wearable device;Well Child Visits;Youth

PROJECT_TITLE: Primary Care Referrals to a Remotely Delivered Physical Activity Intervention for Latina Teens

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Project Narrative:  DNA double-strand breaks (DSBs) are the most lethal type of DNA damage, since unrepaired DSBs lead to genomic instability and tumorigenesis. We have identified NUDT16 protein as a novel regulator of the DNA repair pathways. The proposed studies will elucidate the coordination of different DNA repair pathways and uncover key components in these pathways that we can explore to improve cancer therapy and overcome therapeutic resistance.

PI_NAMEs: GONG, ZIHUA  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Acceleration;Address;ADP ribosylation;artemis;B-Lymphocytes;Binding Sites;BRCA1 gene;Cancer Biology;cancer therapy;Cell Cycle Checkpoint;Cell Survival;Cells;Chromosomal translocation;Chromosome abnormality;Complex;Critical Pathways;Data;Defect;Development;DNA;DNA Damage;DNA damage checkpoint;DNA Double Strand Break;DNA Repair;DNA Repair Pathway;Double Strand Break Repair;Excision;Failure;Frequencies;Genome Stability;Genomic Instability;Goals;Growth;Homologous Gene;homologous recombination;Hydrolase;Immunoglobulin Class Switching;Immunoglobulin Switch Recombination;Impairment;improved;in vivo;Incidence;insight;Lead;Lymphocyte;Lymphoma;Lymphomagenesis;Maintenance;Malignant Neoplasms;Mediating;mouse model;Mus;NBS1 gene;Neoplastic Cell Transformation;Nonhomologous DNA End Joining;novel;novel therapeutic intervention;p53-binding protein 1;Pathway interactions;Patients;Physiological;Play;Post-Translational Protein Processing;prevent;Prevention;Proteins;recombinational repair;recruit;Regulation;repaired;response;Role;Signal Pathway;Spleen;Structure of germinal center of lymph node;therapy resistant;tumor;tumorigenesis;ubiquitin-protein ligase;Ubiquitination;Weight;Work

PROJECT_TITLE: The role of NUDT16 in DNA damage response and tumorigenesis

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Currently, there are no effective therapies to promote kidney repair following acute kidney injury. Consequently, many patients develop chronic kidney disease and other long-term risks including cardiovascular events and reduced quality of life. By investigating the mechanistic basis and therapeutic potential of endothelial hypoxia-induced glycolysis/MCT4 axis in post-ischemic kidney repair, our studies will stimulate new areas for experimental therapeutics in AKI.

PI_NAMEs: KAPITSINOU, PINELOPI P. (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;Affect;alpha ketoglutarate;Area;Blood Vessels;Cardiovascular system;Cell Communication;cell type;Cells;Chronic Kidney Failure;Clinical;Coupled;defined contribution;deprivation;effective therapy;Endothelial Cells;Endothelium;Enzymes;epithelium regeneration;Event;experimental study;Fibrosis;Gene Expression Profile;Genes;genetic approach;Genetic Models;global health;Glycolysis;Glycolysis Induction;Goals;HIF1A gene;Homeostasis;Human;Hypoxia;Hypoxia Inducible Factor;hypoxia inducible factor 1;Immune response;In Vitro;Individual;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injury;Injury to Kidney;innovation;insight;Investigational Therapies;Ischemia;Kidney;kidney fibrosis;kidney repair;kidney vascular structure;Knowledge;Lactate Transporter;Link;Mediating;Mediator;Metabolic;Metabolic Pathway;Molecular;monocyte;Morbidity - disease rate;mortality;Mouse Strains;Mus;novel;Oxygen;Pathway interactions;Patients;Phenotype;prevent;Procollagen-Proline Dioxygenase;programs;Protein Isoforms;Proteins;Quality of life;renal ischemia;repaired;reparative process;Research;response;Risk;Role;Scheme;sensor;Signal Transduction;single-cell RNA sequencing;Supplementation;targeted treatment;Testing;Therapeutic;therapeutic target;tissue injury;Tissues;transcriptomics;Up-Regulation;Vascular Endothelium

PROJECT_TITLE: Endothelial oxygen sensing and metabolic reprogramming in AKI to CKD transition

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Machine Learning and Artificial Intelligence;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Prevention;Serious Mental Illness

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative Biomarkers for predicting antidepressant responses to ketamine and transcranial magnetic stimulation have the potential to transform the management of depression by rapidly matching individual patients to the treatment most likely to benefit them. Here, we will optimize and test novel neuroimaging biomarkers for predicting antidepressant responses in the brains of individual patients.

PI_NAMEs: LISTON, CONOR M (contact);MURROUGH, JAMES WARREN;WILLIAMS, NOLAN R.;ZEBLEY, BENJAMIN

PROGRAM_OFFICER_NAME: FERRANTE, MICHELE

PROJECT_TERMS: Acceleration;Affect;analog;Anterior;anti-depressive agents;antidepressant effect;Awareness;behavior measurement;Biological;Biological Markers;biomarker development;biomarker validation;Brain;brain behavior;Clinical;clinical phenotype;Collaborations;Complex;Consensus;cost;Data;Data Set;denoising;Dimensions;disability;Disease remission;disorder subtype;effective therapy;efficacy evaluation;FDA approved;Foundations;Functional Magnetic Resonance Imaging;functional MRI scan;Goals;Heterogeneity;Individual;Individual Differences;individual patient;individualized medicine;innovation;insight;Insula of Reil;Intravenous infusion procedures;Joints;Ketamine;Left;Machine Learning;machine learning method;Major Depressive Disorder;Maps;Measures;Mental Depression;Modeling;Motor Cortex;Neurobiology;neuroimaging;neuroimaging marker;neuroregulation;novel;novel strategies;Outcome;outcome prediction;Participant;Patients;Pattern;Performance;Phase;Pilot Projects;predicting response;Prediction of Response to Therapy;predictive marker;predictive modeling;Prefrontal Cortex;Procedures;Productivity;prospective;Randomized;randomized, clinical trials;Randomized, Controlled Trials;recruit;repetitive transcranial magnetic stimulation;Reproducibility of Results;Research Personnel;response;Selection for Treatments;Signal Transduction;Site;Symptoms;synaptogenesis;System;Testing;Thalamic structure;Time;Transcranial magnetic stimulation;Treatment outcome;treatment-resistant depression;trial design;Uncertainty

PROJECT_TITLE: Biomarker-Guided Antidepressant Selection for Treatment-Resistant Depression

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-L (05)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Social Determinants of Health;Substance Misuse

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Effective response to the overdose crisis requires rigorously conducted scientific investigations, with a specific focus on criminal legal system, to identify interventions, strategies and approaches that are efficient, feasible, scalable, and sustainable. Phase I of the Justice Community Overdose Innovation Network (JCOIN) created under the NIDA HEAL initiative funded a series of investigations targeting key stages of the substance use treatment continuum as people with substance use disorders interact with the criminal legal system. Together with the new research hubs that will be identified during JCOIN Phase II, these studies will generate a large amount of rich data from the most vulnerable populations in the U.S. opening opportunities for analyses beyond the primary study aims to maximize the impact of investment into scientific research – one of the primary foci of the Methodology and Advanced Analytics Resource Center (MAARC).

PI_NAMEs: BREWER, RUSSELL ;POLLACK, HAROLD ALEXANDER;SCHNEIDER, JOHN  (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Address;advanced analytics;Affect;American;Archives;behavioral health;Collaborations;Collection;Communities;community based service;community involvement;Community Services;Consultations;Criminal Justice;Data;data harmonization;data infrastructure;data management;Data Set;data sharing;Data Sources;Data Storage and Retrieval;Empirical Research;Ensure;environmental change;Epidemic;Equipment and supply inventories;experience;experimental study;Face;Funding;General Population;Helping to End Addiction Long-term;High Prevalence;Imprisonment;improved;in silico;Individual;Infrastructure;innovation;Intervention;Investigation;Investments;Justice;Leadership;Legal;Legal system;Medicaid;member;Methodology;Modeling;National Institute of Drug Abuse;network models;novel;Opiate Addiction;Opioid;opioid misuse;organizational structure;Overdose;overdose death;overdose risk;Persons;Phase;Policies;Policy Maker;Public Health;Recording of previous events;Research;Research Personnel;Resources;response;Risk;Sampling;Scanning;Scientist;Series;Service setting;Services;social stigma;Speed;substance use;Substance Use Disorder;substance use treatment;Supervision;Surveys;System;Techniques;tool;United States National Institutes of Health;Vulnerable Populations

PROJECT_TITLE: Methodology and Advanced Analytics Resource Center 2.0

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SXC-E (M2)]