ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Methamphetamine;Neurosciences;Stimulant Use and Misuse;Substance Misuse

PHR: PROJECT NARRATIVE Methamphetamine use disorder is a public health crisis in the United States for which there is currently a lack of FDA-approved therapeutics for cessation and relapse prevention. We found that microglia, the resident immune cell of the brain, respond to methamphetamine by increasing expression of inflammatory genes and can drive relapse to drug-seeking. The current study aims to examine the transcriptional and epigenetic changes that occur in microglia during drug-taking and drug craving and seeking, providing insight into the therapeutic potential of these cells for the treatment of methamphetamine use disorder.

PI_NAMEs: VILCA, SAMARA JO (contact)

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: Abstinence;Adolescence;Adult;Affect;Attenuated;Behavior;Behavioral;Behavioral Paradigm;Bioinformatics;bioinformatics pipeline;Brain;brain cell;Brain region;career;Cell Nucleus;Cells;Cellular Morphology;Chromatin;chromatin modification;Chronic;clinically relevant;Complex;craving;CSF1R gene;Data;Data Analyses;Development;Disease;drug craving;drug isolation;drug of abuse;drug seeking behavior;Drug usage;early life stress;Epigenetic Process;epigenome;experience;FDA approved;Fostering;Gene Expression;Genes;Genetic Transcription;Goals;Home;Immune;Inflammatory;inflammatory marker;inhibitor;insight;Intravenous;late life;Learning;Libraries;Life;life span;Maintenance;maternal separation;Mediating;Mental disorders;Mentors;Methamphetamine;methamphetamine exposure;methamphetamine use;Methamphetamine use disorder;Microglia;Modeling;Molecular;Molecular Analysis;Morphology;mouse model;multiple omics;neuroinflammation;novel;Nucleus Accumbens;Persons;Pharmaceutical Preparations;Phase;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Predisposition;prolonged abstinence;Psychological reinforcement;Public Health;Recurrent disease;Regulation;Relapse;relapse prevention;Research;Research Personnel;response;reward processing;RNA;RNA library;Role;Self Administration;Stimulus;Subcutaneous Injections;Substance Use Disorder;Techniques;tenure track;Testing;Therapeutic;Training;transcriptome;transcriptome sequencing;transcriptomics;United States;Work

PROJECT_TITLE: Investigating the role of microglia molecular rhythms in the nucleus accumbens in OUD


ADMINISTERING_IC: NS

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences

ORG_CITY: NASHVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Major Depressive Disorder (MDD) is a debilitating disorder that affects over 300 million people worldwide with no current cure and is associated with severe working memory (WM) deficits. This project investigates how the inhibition of Matrix Metalloproteinase-9 (MMP-9) modulates the firing and morphology of pyramidal and parvalbumin positive (PV) interneurons in the hippocampus, leading to impaired WM. In doing so, this proposal posits MMP-9 modulators as therapeutic interventions for rescuing WM deficits, a symptom in varied neurological disorders including MDD, with the goal of improving public health.

PI_NAMEs: BLANCO, ISMARY  (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Academia;Action Potentials;Advocate;Affect;anti-depressive agents;Behavioral;Behavioral Assay;Calcium;Cells;cholinergic;Collaborations;Communities;Data;Data Analyses;Dedications;Dendrites;Development;Disease;diversity and inclusion;Electrophysiology (science);Equilibrium;Event;excitatory neuron;experience;Extracellular Matrix;Faculty;falls;Fostering;Gelatinase A;Gelatinase B;Gene Expression;Generations;Goals;Grant;hippocampal pyramidal neuron;Hippocampus;Homologous Gene;Image;Impaired cognition;Impairment;improved;Inhibition of Matrix Metalloproteinases Pathway;innovation;Institution;interdisciplinary approach;Interdisciplinary Study;interest;Interneurons;Learning;Major Depressive Disorder;Manuscripts;Matrix Metalloproteinases;Measurement;Memory;Memory impairment;Mental Depression;Mentors;Minnesota;minority student;Modeling;Molecular;Morphology;mouse model;Mus;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;neural circuit;neural correlate;Neurobiology;neuronal cell body;neuronal circuitry;Neurons;Neurosciences;new therapeutic target;Optics;Parvalbumins;patch clamp;patch sequencing;Patients;Persons;Phase;Plasminogen;Population;post-doctoral training;Postdoctoral Fellow;pre-doctoral;programs;Property;Proteomics;Public Health;Research;Research Personnel;Research Project Grants;Resistance;Resource Sharing;Role;Scientist;Short-Term Memory;skills;Stress;symposium;Symptoms;System;Techniques;Therapeutic Intervention;therapeutic target;Thinking;timeline;Training;Travel;Universities;venlafaxine;versican;Work;Writing;Zebrafish

PROJECT_TITLE: Inhibition of MMP-9 Activity Impairs Working Memory in Zebrafish Through Changes in Overall Hippocampal Excitation


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Pediatric

ORG_CITY: CHICAGO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Stress alters how the brain processes rewarding and aversive stimuli, thus altering an individual’s motivation to interact with their environment. This project will answer fundamental questions about how the stress hormone corticosterone/cortisol affects dopamine-producing cells in the brain to change motivation. The results of these studies may inform the search for novel therapeutic targets for stress-related motivational deficits.

PI_NAMEs: HOLLOWAY, ASHLEY  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Adolescence;Adolescent;Adult;Affect;Astrocytes;Aversive Stimulus;Award;Behavior;Behavioral;Brain;Calcium;calcium indicator;Calcium Signaling;Cells;Corticosterone;critical period;Development;Dopamine;dopaminergic neuron;Educational process of instructing;Environment;experience;Exposure to;Genetic;genetic manipulation;Glucocorticoids;Goals;Hormones;Hydrocortisone;Image;Impairment;in vivo;Individual;Institution;Leadership;Learning;Major Depressive Disorder;Mental disorders;Mentorship;Monitor;Motivation;Mus;neural;Neurons;new therapeutic target;Operant Conditioning;Population;Positioning Attribute;Process;Regulation;Research;Research Personnel;Resolution;response;Rewards;Risk Factors;skills;Social isolation;Stress;Synaptic plasticity;System;Technical Expertise;Training;Work

PROJECT_TITLE: Glucocorticoid regulation of dopamine circuit function


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Prescription Drug Misuse;Sleep Research;Substance Misuse;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Patients with chronic low back pain are commonly prescribed opioid analgesics despite substantial risk for problematic opioid use. Sleep disruption is a modifiable target that may increase risk for problematic opioid use in patients by increasing abuse liability and decreasing analgesia. Our project investigates the effects of sleep disruption on opioid abuse liability and analgesia in patients with chronic low back pain, the results of which will critically inform clinical decision making related to the prescription of opioids for patients with chronic pain.

PI_NAMEs: FINAN, PATRICK ;SMITH, MICHAEL T (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Absence of pain sensation;abuse liability;Acute;addiction;Address;Adult;Affect;Affinity;American;Analgesics;Attenuated;Behavioral;Brain;Calibration;Chronic;Chronic low back pain;chronic pain patient;clinical decision-making;clinically relevant;Corpus striatum structure;Data;design;Detection;Development;Dose;Epidemic;Euphoria;Evaluation;experience;Female;General Population;Heroin;Human;Hydromorphone;Impairment;indexing;International;Intervention;Knowledge;Laboratories;Laboratory Study;Literature;male;Measurement;Measures;Mediating;Meta-Analysis;Modeling;Morphine;mu opioid receptors;neural circuit;neurobiological mechanism;Neurobiology;novel;Opiate Addiction;Opioid;opioid abuse;Opioid Analgesics;opioid epidemic;opioid exposure;opioid use;Pain;pain model;pain patient;pain sensitivity;Participant;Patient Self-Report;Patients;Pharmaceutical Preparations;pharmacologic;Physiological;Placebo Control;Population;prescription opioid;prevent;Procedures;Recording of previous events;Research Design;response;Rewards;Risk;Risk Assessment;Risk Factors;Role;Running;Sensory;sex;Sex Differences;Sleep;Sleep Disorders;Sleep disturbances;standard measure;Standardization;Stimulus;Substance Use Disorder;Symptoms;synthetic opioid;System;Testing;Ventral Striatum;women versus men

PROJECT_TITLE: Effects of Sleep Disruption on Subjective Responses to Opioid Administration in Patients with Chronic Pain

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Vaccine Related;Vector-Borne Diseases;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Rift Valley fever (RVF) is a mosquito-borne disease that is known for causing fetal death in livestock animals; indeed, live-attenuated RVFV veterinary vaccines can still cause fetal infection in pregnant animals. Using a pregnant rat model, this proposal will determine how current and next-generation vaccines cross the maternal-fetal boundary and the correlates of immune protection required to prevent fetal infection.

PI_NAMEs: HARTMAN, AMY L (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: abortion;Abortion Rates;Address;Adult women;Africa;Americas;Animal Diseases;Animals;Attenuated;Attenuated Live Virus Vaccine;Attenuated Vaccines;Biological Response Modifiers;Cells;clinically relevant;comparative;Culicidae;Data;Development;Disease;Disease Outbreaks;Economics;emerging virus;Europe;Evaluation;fetal;Fetal Death;Fetal Development;fetal infection;fetal loss;Fetus;health assessment;Hemorrhage;Human;Immune;Immune response;Induced Abortion;Infection;Infection prevention;Inflammation;Livestock;malformation;Maternal-Fetal Transmission;mature animal;Middle East;Modeling;mosquito-borne;Mosquito-borne infectious disease;next generation;novel vaccines;Outcome;pathogen;Pathology;permissiveness;Persons;Placenta;pre-clinical;Predisposition;Pregnancy;pregnant;prepregnancy;prevent;Production;public health emergency;Rattus;Rift Valley Fever;Rift Valley fever virus;Rodent Model;safety assessment;Sheep;Spontaneous abortion;Structure;Testing;Time;transmission process;Tropism;Vaccination;vaccine candidate;vaccine development;vaccine efficacy;vaccine safety;Vaccines;Vertical Transmission;Viral Load result;Virulent;Virus;Virus Diseases;World Health Organization;Zoonoses

PROJECT_TITLE: Live-attenuated Rift Valley fever vaccines:  comparative mechanisms of trans-placental transmission and vaccine efficacy for developing fetuses

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Batten Disease;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: ROCHESTER

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Juvenile Neuronal Ceroid Lipofuscinosis (CLN3 disease) is a rare, fatal, pediatric disease that lacks disease- modifying treatments. Several candidate compounds are advancing through the therapeutic pipeline, but will face barriers to development resulting from for unmet research needs. This project will overcome these barriers to validate sensitive measures of how patients feel and function, validate neuroimaging biomarkers of disease progression, and prepare these tools for multi-site use, immediately setting the stage for rigorous and efficient clinical trials in CLN3 disease.

PI_NAMEs: AUGUSTINE, ERIKA  (contact)

PROGRAM_OFFICER_NAME: MENDOZA-PUCCINI, MARIA CAROLINA

PROJECT_TERMS: Address;Affect;Age;Assessment tool;Award;Biological Markers;biomarker validation;Blindness;Brain;brain volume;Cessation of life;Child;Childhood;Clinical;Clinical assessments;clinical care;clinical outcome assessment;clinical phenotype;clinical trial implementation;clinical trial readiness;Clinical Trials;CLN3 gene;Collaborations;Complex;Cross-Sectional Studies;Data;Decision Making;design;Development;Disease;Disease Progression;drug development;Ensure;Epilepsy;European;Evaluation;Event;Face;Fostering;Foundations;Future;Germany;gray matter;Image;Impaired cognition;inclusion criteria;indexing;Individual;interest;International;juvenile neuronal ceroid lipofuscinosis;Life;longitudinal analysis;Magnetic Resonance Imaging;Manuals;Measurable;Measurement;Measures;Modeling;motor disorder;Multicenter Trials;Natural History;Nerve Degeneration;neuroimaging;neuroimaging marker;Neuronal Ceroid-Lipofuscinosis;neuropathology;New York;novel therapeutics;optimism;Outcome;Patients;Phase;phase II trial;Phenotype;premature;Preparation;Process;programs;prospective;Qualifying;Rare Diseases;Readiness;Reproducibility;Research;Sampling;Severity of illness;Signs and Symptoms;Site;Spielmeyer-Vogt Disease;Staging System;Symptoms;Testing;Therapeutic;Therapeutic Effect;Therapeutic Trials;Thick;Time;time interval;timeline;tool;tool development;Training Programs;United States Food and Drug Administration;Universities;Visit;white matter

PROJECT_TITLE: Meaningful Outcomes and Multi-Site Readiness for Clinical Trials in Juvenile Neuronal Ceroid Lipofuscinosis


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE/SUMMARY STATEMENT Lung cancers harboring ErbB mutations are significant causes of morbidity and mortality (>35,000 deaths yearly) in the United States; comprising a distinct collection of malignancies defined by driver oncogenes addicted to their signaling cascades. This concept has translated rapidly into one of the most effective class of palliative therapies for NSCLCs: genotype-matched precision kinase inhibitors. The identification of novel inhibitors and/or combination therapies for EGFR exon 20 insertions is essential to understand the promises plus limitations of precision treatments for in this important patient cohort.

PI_NAMEs: COSTA, DANIEL BOTELHO (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Adenosine Kinase;Adenosine Triphosphate;Affinity;Amino Acids;Antibodies;antitumor effect;Apoptotic;Binding;Biology;Biopsy;Cancer Etiology;cancer therapy;Cell Death;Cell Line;Cessation of life;Clinical;clinical care;clinical development;clinical efficacy;Clinical Trials;cohort;Collection;Combined Modality Therapy;confirmatory clinical trial;Data;Development;Disease;Dose;driver mutation;effective therapy;EGFR gene;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;ERBB2 gene;Erlotinib;Exons;experimental study;Future;Gefitinib;Generations;Genetically Engineered Mouse;Genomics;Genotype;Goals;improved;in vivo Model;Induction of Apoptosis;inhibitor therapy;Insertion Mutation;insertion/deletion mutation;kinase inhibitor;Kinetics;Liquid substance;Lung Adenocarcinoma;Malignant neoplasm of lung;Malignant Neoplasms;men;Mitochondria;Modeling;Morbidity - disease rate;mortality;mutant;Mutate;Mutation;Non-Small-Cell Lung Carcinoma;novel;novel therapeutics;oncogene addiction;Oncogenes;Outcome;Palliative Care;Pathway interactions;Patient Care;Patients;Pharmaceutical Preparations;Phosphotransferases;Point Mutation;pre-clinical;Pre-Clinical Model;Precision therapeutics;prevent;Quality of life;radiological imaging;rational design;refractory cancer;Reporting;Research;Resistance;resistance mechanism;response;Scheme;Signal Transduction;Structure;Subgroup;Testing;Therapeutic;Therapeutic Index;Tissues;Translating;translational goal;tumor;Tyrosine Kinase Inhibitor;United States;Woman;Xenograft procedure

PROJECT_TITLE: Unmet needs for specific subsets of EGFR mutated lung cancer


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: HARVARD UNIVERSITY

PHR: The cerebral cortex, where high-level cognition, association, integration, and motor and sensory processing occurs, contains thousands of distinct types of specialized nerve cells (neurons) enabling it to perform such complex tasks; callosal projection neurons (CPN) are the class of neurons connecting the cerebral hemispheres to integrate cortical information, playing key roles in human behavior and disease. People with abnormalities of their corpus callosum (CC), the structure composed of CPN axons linking the hemispheres, exhibit a range of cognitive and behavioral disease, including intellectual disability, autism, and some types of mental illness, highlighting the importance of proper CPN/CC development; however, little is known about genes and molecules regulating CPN development. Building on recent work identifying the first candidate CPN control molecules, this project will pursue deep and rigorous functional investigation of a newly identified transcriptional co-regulator, Cited2, that appears to centrally regulate development and refinement of this important neuronal population; these investigations will 1) apply novel experimental approaches to identify critical functions of this control gene in development of CPN connections in mice; 2) more broadly elucidate networks of molecules in axon “growth cones” controlled by Cited2 whose disruption might cause and underlie CPN abnormalities and human diseases involving CPN; and 3) have future potential to identify new ways to diagnose, treat, or prevent such cognitive, associative, and behavioral disorders.

PI_NAMEs: MACKLIS, JEFFREY D (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Area;autism spectrum disorder;Axon;axon growth;Behavior;Behavior Disorders;behavior test;Behavioral;behavioral phenotyping;Brain;candidate validation;Cells;Cerebral cortex;Cerebral hemisphere;Cognition;Cognitive;combinatorial;Complex;Corpus Callosum;Development;Developmental Biology;developmental disease;Diagnosis;Disease;Electroporation;Evolution;Exhibits;Functional disorder;Future;gain of function;Gene Expression;Gene Expression Regulation;Generations;Genes;genetic analysis;genetic manipulation;Genetic Transcription;Goals;Growth Cones;hippocampal pyramidal neuron;Human;human disease;in utero;Individual;innovation;insight;Intellectual functioning disability;interest;Investigation;Knowledge;Label;Link;Location;Maps;Mental disorders;Molecular;mosaic;mosaic analysis;Motor;Mus;Nature;neocortical;neuron development;neuronal cell body;neuronal circuitry;neuronal growth;Neurons;novel;novel strategies;Parents;Persons;Phenotype;Plasmids;Play;Population;Population Analysis;Positioning Attribute;postmitotic;prevent;Prevention;Process;progenitor;programs;Proteins;Proteome;Proteomics;Publishing;recombinase;Regulation;Research;RNA;Role;Schizophrenia;Sensory;somatosensory;Somatosensory Cortex;Specific qualifier value;Structure;System;Technology;Therapeutic;Time;tool;Transcriptional Regulation;transcriptomics;Visualization;Work

PROJECT_TITLE: Molecular Development and Diversity of Callosal Projection Neurons

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: In this application we propose to validate a positron emission tomography (PET) imaging agent as biomarker for synaptic density. As many brain disorders are thought of as “synaptic diseases”, the use of PET imaging to detect synaptic density and its changes in diseases will provide a potentially paradigm-shifting tool to investigate and diagnose Alzheimer's disease and other neurologic disorders, and monitor treatment outcomes.

PI_NAMEs: HUANG, YIYUN HENRY (contact);VAN DYCK, CHRISTOPHER H

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: abeta oligomer;Affect;Age;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease therapy;American;Amyloid beta-Protein;amyloid imaging;analog;Autopsy;Binding;Biological Markers;Blood Glucose;Brain;Brain Diseases;cell cortex;Clinic;Clinical;Clinical Trials;cognitive function;Communities;Coupled;Data;Dementia;density;Development;Diagnostic;Disease;Disease Progression;entorhinal cortex;Event;Fasting;FDA approved;Female;Fluorine;fluorodeoxyglucose;Frontotemporal Dementia;glucose metabolism;Glycoproteins;Goals;Half-Life;Hippocampus;Human;human subject;Image;imaging agent;imaging biomarker;imaging properties;Impaired cognition;In Vitro;in vivo;in vivo imaging;Individual;Institution;Investigation;Keppra;kinetic model;Kinetics;Label;Levetiracetam;Limbic System;male;Measures;Medical Imaging;Membrane Proteins;Methods;mild cognitive impairment;Molecular Target;Monitor;Multi-Institutional Clinical Trial;Multicenter Trials;Nervous System Disorder;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroimaging;neuroimaging marker;Neurons;neuropsychiatric disorder;Pathogenesis;Pathology;Patients;Persons;Pharmaceutical Preparations;Positron-Emission Tomography;pre-clinical;presynaptic;Preventive;Production;Property;Protein Isoforms;Proteins;Protocols documentation;quantitative imaging;Radioisotopes;radioligand;radiotracer;Regulation;Reproducibility;Research;Resolution;Scanning;Senile Plaques;Signal Transduction;Site;Synapses;synaptic failure;Synaptic Vesicles;Synaptophysin;Testing;tomography;tool;Tracer;trafficking;Treatment Efficacy;Treatment outcome;Treatment Protocols;uptake;Validation;Vesicle;virtual;white matter

PROJECT_TITLE: Validation of Fluorine-18 radioligand for PET imaging of synaptic density in Alzheimer's disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Services;Neurodegenerative;Neurosciences;Palliative Care

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative  Recommendations of the National Alzheimer’s Project Act as well as the National Research Summits on Care, Services, and Supports for Persons with Dementia and their Caregivers have called for continued creation of innovative, scalable, and sustainable community-based supports for older persons with Alzheimer’s disease and Alzheimer’s disease related dementias (AD/ADRD) and their caregivers. The proposed real-world efficacy trial (Stage III of the NIH Stage Model) features an established collaboration between Lutheran Social Service of Minnesota and the University of Minnesota to evaluate a novel adaption of a statewide volunteer program (the “Porchlight Project”) to assist people with AD/ADRD and their family caregivers better manage dementia at home. If successful, the Porchlight Project will offer a potentially efficient, wide-ranging service model for states and communities to implement for volunteers, persons with AD/ADRD, and family caregivers.

PI_NAMEs: GAUGLER, JOSEPH E. (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Address;Adverse effects;Alzheimer's Disease;Alzheimer's disease related dementia;Attention;care systems;Caregiver well-being;Caregivers;Caring;Collaborations;Communities;Community Services;Companions;Competence;cost;cost effectiveness;Data Collection;Dementia;dementia care;Dementia caregivers;design;Disease;efficacy trial;Elderly;Elements;Evaluation;Family;Family Caregiver;Fertility Rates;Friends;Funding;global health;Goals;Health;Home;Hour;improved;improved outcome;Individual;Information Systems;innovation;insight;Intervention;Interview;Knowledge;Loneliness;low socioeconomic status;Lutheran Church;Measurement;Measures;Methods;Minnesota;Modeling;novel;Older Population;Outcome;patient home care;Patient Outcomes Assessments;Patient Self-Report;person centered;Personal Satisfaction;Persons;Population;programs;Quality of life;Randomized;Recommendation;Research;Self Efficacy;Service delivery model;Services;Social Work;Stress;Surveys;symposium;Training;Training Activity;Training Programs;training project;treatment as usual;trend;United States National Institutes of Health;Universities;Visit;volunteer;Work

PROJECT_TITLE: The PorchLight Project

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Aging

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative-Health Relevance A decline in mitochondrial function occurs during aging, which is accelerated in age-associated diseases such as Parkinson's and Alzheimer's. Thus, understanding how cells and organisms generate the appropriate mitochondrial mass during development and maintain that mitochondrial network during aging is an important step to limiting pathologies associated with loss of mitochondrial function. In this proposal, we aim to understand the underlying mechanisms by which a single transcription factor coordinates mitochondrial network biogenesis and recovery via independent functions in mitochondrial compartments and the nucleus. !

PI_NAMEs: HAYNES, COLE M (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Acceleration;activating transcription factor 1;age-related disease;Aging;Alzheimer's Disease;Animals;ATP-Dependent Proteases;Binding;Biogenesis;bZIP Protein;cell growth;Cell Nucleus;cell type;Cells;common cellular transcription factor ATF;Constitution;Data;Development;Developmental Delay Disorders;Diapause;Ensure;extend lifespan;Feedback;Fibroblasts;Functional disorder;Funding;Genes;Genetic Transcription;Health;Heterogeneity;Individual;Insulin Receptor;Link;Mediating;misfolded protein;Mitochondria;mitochondrial autophagy;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial genome;Mitochondrial Proteins;Muscle;Natural regeneration;Neurons;Nuclear;Organelles;Organism;Parkinson Disease;Pathology;Peptide Hydrolases;Physiological;Physiology;Polymerase;programs;Proteins;Receptor Signaling;Recovery;Regulation;repaired;response;sensor;Signal Pathway;Specific qualifier value;Stress;Testing;Time;transcription factor;ZIP protein

PROJECT_TITLE: Coordinated Repair and Regeneration of Defective Mitochondria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-A(02)M]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Hearing Loss;Neurosciences;Pediatric;Prevention

PHR: Project Narrative The proposed research addresses a long-standing and important challenge of improving language skills of children who are deaf and hard of hearing, a historically under researched group. We aim to leverage retrieval practice – a empirically validated intervention approach – for improving how efficiently children who are deaf and hard of hearing learn and retain new words. The knowledge gained will guide language intervention for children who are deaf and hard of hearing.

PI_NAMEs: MCDANIEL, JENA C (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: 8 year old;Address;Adult;Age;Area;Attention;Characteristics;Child;Child Development;Clinical;Cognitive Science;Cues;deaf;Development;Disabled Persons;Education;Educational process of instructing;effective intervention;Effectiveness;effectiveness evaluation;Evaluation;Evidence based intervention;Exhibits;Exposure to;Feedback;Future;Goals;hard of hearing;Hearing;Illusions;improved;Individual Differences;innovation;Intervention;intervention effect;Intervention Studies;Knowledge;Language;Language Development;Learning;Maintenance;Mediating;Modality;novel;Outcome;Pattern;peer;Population Heterogeneity;prevent;Randomized, Controlled Trials;Research;Research Design;response;Retrieval;Risk;Sign Language;skills;Special Education;Students;success;Teaching Materials;therapy design;Visual;Vocation;word learning;Work

PROJECT_TITLE: Increasing Word Learning Efficiency in Children who are Deaf and Hard of Hearing through Retrieval Practice

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric

ORG_CITY: Wilmington

ORG_NAME: NEW ENGLAND RESEARCH INSTITUTES, INC.

ORG_STATE: DE

PHR: PROJECT NARRATIVE  The mission of the Pediatric Heart Network is to improve health outcomes in patients with pediatric acquired and congenital heart disease; disseminate collaborative findings as the basis for improved evidence- based treatment options and standards of care; train and educate new investigators, and provide support and advocacy for families during the conduct of excellent, ethical clinical research. The Data Coordinating Center provides the network infrastructure to support this research.

PI_NAMEs: MILLER, JULIE ELAINE (contact);TRACHTENBERG, FELICIA LYNN

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: Advocacy;Agreement;Biometry;Budgets;Caring;Childhood;clinical center;Clinical Research;Clinical Trials Data Monitoring Committees;Collaborations;Communication;Conflict of Interest;congenital heart abnormality;Data;data acquisition;Data Analyses;Data Coordinating Center;Data Files;data management;data quality;Data Reporting;Data Set;Development;electronic data capture system;Electronics;Enrollment;Ensure;Ethics;European;Evidence based treatment;Expenditure;experience;Family;Funding;Good Clinical Practice;Health;Health Policy;Heart;improved;Information Dissemination;Information Systems;Infrastructure;innovation;Institutional Review Boards;Investigational New Drug Application;investigator training;Leadership;Logistics;Maintenance;Medicine;meetings;member;Methodology;Mission;Monitor;National Heart, Lung, and Blood Institute;Network Infrastructure;New England;novel;operation;Outcome;Patients;payment;Periodicals;Pharmaceutical Preparations;Productivity;protocol development;Protocols documentation;Publications;quality assurance;Quality Control;recruit;remote monitoring;Reporting;Request for Proposals;Research;Research Design;Research Institute;Research Personnel;Research Support;Resources;Role;Running;Safety;Sample Size;Scientist;Services;Site;Site Visit;statistics;symposium;System;Technology;timeline;tool;Training;Travel;United States Food and Drug Administration;United States National Institutes of Health;Update;web site;webinar;Writing

PROJECT_TITLE: Data Coordinating Center for the Pediatric Heart Network


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Childhood Injury;Clinical Research;Machine Learning and Artificial Intelligence;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Preterm, Low Birth Weight and Health of the Newborn;Unintentional Childhood Injury

PHR: Narrative Toward our long-term goal of delivering precision medicine for the treatment of neonatal hypoxic-ischemic encephalopathy (HIE), we plan to develop a methodological framework with which to classify HIE based on brain MRI evaluation combined with clinical variables to better predict neurological prognosis. In this proposal, we will create a neonatal brain MRI quantification tool to identify various types of lesions, and apply the tool to the cohort of HIE neonates to identify the neuroanatomical features of the brain, which, combined with maternal and neonatal clinical variables, will isolate HIE subtypes and subsequent clinical phenotypes to predict prognosis. The stratification of HIE subtypes and the specific prognoses proposed in this application is essential for developing and delivering targeted adjuvant and rehabilitative treatments and is also necessary for medical providers in order to guide the appropriate allocation of resources.

PI_NAMEs: OISHI, KENICHI  (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: 2 year old;Adjuvant;Affect;Age Months;Algorithms;Anatomy;Area;Atlases;Basal Ganglia;Biochemical;Brain;Brain Injuries;brain magnetic resonance imaging;Caregivers;Characteristics;Classification;classification algorithm;Clinical;clinical phenotype;cohort;Cohort Studies;Data;Deformity;Detection;detection method;Development;Diagnosis;Diffusion;Diffusion Magnetic Resonance Imaging;Early Intervention;Educational process of instructing;Electroencephalography;Evaluation;Exposure to;functional outcomes;Future;Goals;Growth;Image;Image Analysis;imaging modality;Infant;infant outcome;interest;Label;Language;learning algorithm;Lesion;Libraries;Link;Localized Lesion;Magnetic Resonance Imaging;Manuals;medically necessary care;Methodology;Morphology;Motor;Neonatal;neonatal brain;neonatal hypoxic-ischemic brain injury;neonatal period;neonate;Neuroanatomy;neurobehavioral;neuroimaging;Neurologic;Neurological outcome;Outcome;outcome prediction;Pathologic;patient stratification;Performance;personalized predictions;Phenotype;precision medicine;predictive marker;Predictive Value;Premature Birth;prenatal exposure;Prognosis;Protocols documentation;Provider;Qualitative Evaluations;Rehabilitation therapy;Resource Allocation;Risk;Scanning;Sensitivity and Specificity;Serum Markers;Severities;Signal Transduction;Specificity;Stratification;Structure;Subgroup;supervised learning;targeted delivery;Technology;Testing;tool;Translating;validation studies

PROJECT_TITLE: Precision Medicine for Neonatal Hypoxic-Ischemic Encephalopathy: Combined Neuroimaging Clinical Approach to Link Phenotypes to Prognosis

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: SAN ANTONIO

ORG_NAME: TEXAS BIOMEDICAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: Narrative - Overall There is an acute national shortage of rhesus monkeys of Indian origin, which are models of HIV/AIDS, but also other important infectious diseases such as HIV/AIDS co-infections, tuberculosis, malaria, and COVID-19. The Southwest National Primate Research Center maintains a genetically diverse specific pathogen free (SPF) Indian-origin rhesus macaque colony. This proposal seeks to maintain and expand this colony to better serve the needs of the national AIDS research community.

PI_NAMEs: HALL-URSONE, SHANNAN ;KAUSHAL, DEEPAK  (contact)

PROGRAM_OFFICER_NAME: SUI, YONGJUN

PROJECT_TERMS: Academia;Acquired Immunodeficiency Syndrome;Acute;Affect;Air;Alleles;Animals;Antibodies;Antigens;Area;Biomedical Research;Breeding;California;China;Climate;co-infection;Communicable Diseases;Communities;Country;COVID-19;COVID-19 pandemic;COVID-19 testing;COVID-19 vaccine;Crossbreeding;Data;deep sequencing;Development;Drug Industry;Ensure;Evaluation;exome sequencing;Faculty;Female;Frequencies;Fund Raising;Funding;Future;Genetic;genetic pedigree;Genetic Variation;genome sequencing;Genotype;germ free condition;Goals;Grant;Growth;Haplotypes;Hemorrhage;HIV;HIV vaccine;HIV/AIDS;Housing;In Situ;Individual;Infectious Diseases Research;Infrastructure;Institution;Investments;Laboratories;Macaca;Macaca mulatta;Maintenance;Malaria;member;MHC Class I Genes;Mission;model development;Modeling;New England;nonhuman primate;Occupations;Outsourcing;pandemic disease;Pathogenesis;Performance;Pertussis;Population;Positioning Attribute;pressure;Primates;Production;programs;Recommendation;recruit;Reporting;reproductive;Research;Research Institute;Research Personnel;Resources;Rhesus;Sales;Sampling;SARS-CoV-2 infection;Scientist;screening;Secure;Serology;Simian T-lymphotropic virus 1;SIV;Source;Technology;Texas;Therapeutic;therapeutic development;therapeutic evaluation;Time;Tuberculosis;United States National Institutes of Health;vaccine development;vaccine evaluation;Vaccines;Virus;virus testing;Western Blotting;whole genome

PROJECT_TITLE: Establishment of a SPF Rhesus Macaque Colony

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-J(52)]


PHR: Narrative – Core A: Husbandry and Management Core This project will manage a U42-supported production colony of SPF Indian-origin rhesus macaques prioritized for AIDS-related research. Goals include a planned increase in colony size, and ultimately an increased number of rhesus available for approved research projects, in response to unprecedented national demand. A coordinated team of managers, veterinarians, behaviorists, geneticists, virologists, and resource scientists will oversee this critical national resource.

PI_NAMEs: KAUSHAL, DEEPAK  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Age;Air;Alleles;Animal Husbandry;Animals;Area;Behavioral;Breeding;COVID-19 pandemic;Data;deep sequencing;Ensure;Female;Fertility;Funding;Genetic;genetic pedigree;Genetic Variation;genome sequencing;Genomics;Genotype;germ free condition;Goals;Grant;Growth;Health;Heterozygote;Inbreeding;Institution;Macaca;Macaca mulatta;Methods;MHC Class I Genes;model development;Modeling;Monitor;Monkeys;New England;Occupations;Phenotype;Positioning Attribute;Practice Management;Primates;Production;programs;reproductive;Research;Research Personnel;Research Project Grants;Resources;response;Rhesus;Scheme;Scientist;Source;success;surveillance data;Therapeutic;Time;United States National Institutes of Health;vaccine development;Veterinarians;virus testing

PROJECT_TITLE: Animal Husbandry Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-J]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity

ORG_CITY: SAN DIEGO

ORG_NAME: SCINTILLON INSTITUTE FOR PHOTOBIOLOGY

ORG_STATE: CA

PHR: Project Narrative The rising prevalence of obesity and eating disorders is a significant public health crisis, and dysfunctions of cortical and subcortical circuits important for motivation and reward processing have been implicated. This proposal will address how cerebellar circuits influence food seeking and consumption. Through a combination of molecular-genetic tools, imaging and quantitative behavioral and metabolic analysis, we will dissect the connectivity and function of a newly-identified brain center that regulates feeding behavior, with a long-term goal of exploring the efficacy of drugs and behavioral modifications as effective therapeutics for body weight control.

PI_NAMEs: BETLEY, JOHN NICHOLAS;CHEN, ALBERT  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Anatomy;Appetite Stimulants;Association Learning;Behavior;Behavior Therapy;Behavioral;Biological Assay;Body Weight;Brain;Brain imaging;Brain region;calcium indicator;cerebellar lesion;Cerebellar Nuclei;Cerebellum;Cerebral cortex;Cognitive;Complex;Consumption;Data;Dedications;Development;Dissociation;drug efficacy;drug modification;Eating;Eating Disorders;experimental study;feeding;Feeding behaviors;Food;food consumption;Functional disorder;Functional Magnetic Resonance Imaging;Gastrointestinal tract structure;Genetic;genetic approach;Goals;Hunger;Hypothalamic structure;Image;Infusion procedures;insight;Lateral;limb movement;Link;Logic;Maps;Measures;Mediating;Metabolic;Metabolism;Methods;Molecular;Molecular Genetics;Motivation;motivational processes;Motor;motor control;Motor Pathways;Mus;Nervous System Disorder;Nervous System Trauma;neural;Neurons;novel;Nutrient;obese patients;Obesity;optogenetics;Output;paraventricular nucleus;Pathway interactions;Pattern;Physiological;Population;Prevalence;Process;Property;Public Health;Publishing;Rabies;Rabies virus;reduced food intake;reward processing;Rewards;Rodent;Role;Satiation;satiety center;Signal Transduction;skills;Stomach;Structure;Structure of nucleus infundibularis hypothalami;Synapses;Testing;Thalamic structure;Therapeutic;therapeutically effective;tool;treatment strategy;Viral;Weight maintenance regimen;zona incerta

PROJECT_TITLE: Defining the functional organization of cerebellar output circuits that control feeding behavior

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


NIH_SPENDING_CATS: Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: We will study mechanisms that control maturation of spinal cord motor neurons. Understanding this process will enable us to accelerate maturation of stem cell-derived neurons, leading to more accurate models for adult onset degenerative diseases, such as ALS.

PI_NAMEs: WICHTERLE, HYNEK  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Acceleration;Adolescent;Adult;aged;Amyotrophic Lateral Sclerosis;Area;Binding;Cell Nucleus;Chromatin;chromatin modification;Chromosome Mapping;computerized tools;Data;Degenerative Disorder;Development;differentiation protocol;DNA;DNA mapping;drug discovery;Electrophysiology (science);Embryo;embryonic stem cell;Enhancers;Family;Fibroblasts;Functional disorder;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;Genetic Transcription;Genomic approach;Global Change;Goals;Hormones;In Vitro;in vivo;insight;Late-Onset Disorder;longitudinal dataset;Longitudinal Studies;Maps;Methodology;Methods;Modeling;Motor Neurons;Mus;Nervous System;neural circuit;Neurodegenerative Disorders;Neurons;Nucleic Acid Regulatory Sequences;patient - derived stem cells;pluripotent stem cell differentiation;Pluripotent Stem Cells;Post-Translational Protein Processing;postmitotic;postnatal;Process;programs;Regulation;Regulatory Element;Reporter;Role;Signal Transduction;Signaling Molecule;Specific qualifier value;Spinal Cord;stem cell differentiation;stem cells;Testing;transcription factor;Transcriptional Regulation;Work

PROJECT_TITLE: Transcriptional Control of Motor Neuron Maturation

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Public Health Relevance:  A genetic risk for obesity does not always translate to the development of obesity among children, which points to the presence of risk-modifying factors that likely relate to energy balance behaviors as key behavioral drivers. Using an integrated approach to comprehensively examine the interplay between genotype and phenotype, this study will systematically assess the extent to which energy balance behaviors, alone or in combination, in conjunction with family-level influences can modify behavioral and genetic predispositions to childhood obesity in a high-risk sample of predominantly minority children from low-resource backgrounds. Identifying protective factors that may mitigate the impact of obesity risk on weight and adiposity outcomes is critical for moving the prevention of childhood obesity into a new direction.

PI_NAMEs: KRAL, TANJA V.E. (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Address;Adult;Age;Appetitive Behavior;Area;Behavior;Behavioral;behavioral phenotyping;biobehavior;Biology;Body fat;Body mass index;Calories;Child;Child Rearing;Childhood;Chronic Disease;Circadian Rhythms;Complex;Consumption;Desire for food;Diet;Dietary intake;Disease;DNA;early childhood;Eating;Eating Behavior;eating in absence of hunger;energy balance;Energy Intake;Energy Metabolism;Environment;Environmental Risk Factor;Family;Family Characteristics;family influence;feeding;fighting;Food;Genes;Genetic;Genetic Predisposition to Disease;Genetic Risk;genetic risk factor;Genotype;Glean;Goals;health disparity;Heritability;high risk;Household;Individual;Intervention;Knowledge;Learning;Literature;Measures;minority children;Nutritional Study;Obesity;obesity development;obesity in children;obesity prevention;obesity risk;Outcome;Parents;Pattern;Phenotype;Physical activity;precision nutrition;Prevention;primary outcome;prospective;Prospective Studies;protective factors;public health relevance;racial diversity;Research;Resources;Rest;Risk;Risk Factors;risk mitigation;Role;Sampling;Single Nucleotide Polymorphism;Sleep;Socioeconomic Status;Strategic Planning;Stress;System;Testing;Time;trait;Translating;United States;United States National Institutes of Health;Variant;waist circumference;Weight;Youth

PROJECT_TITLE: Role of energy balance behaviors in modifying biobehavioral risk factors for childhood obesity

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


PHR: Narrative – Core B: Viral Testing Core Southwest National Primate Research Center (SNPRC) maintains an Indian origin rhesus macaque (Ind RM) colony that is Specific Pathogen Free (SPF) for SLTV-1, SIV, SRV, and BV to ensure that there is a ready supply of these NHPs for HIV research. In addition, SPF RM are serologically tested for both the parasite Trypanosoma cruzi and for measles antibodies titer to evaluate the efficacy of the measles vaccination program. During the COVID-19 pandemic, SARS-CoV-2 antibody and viral RNA testing has also been performed on the SPF colony.

PI_NAMEs: MEHRA, SMRITI  (contact)

PROJECT_TERMS: 2019-nCoV;Acquired Immunodeficiency Syndrome;Affect;AIDS vaccine development;Algorithms;animal care;Animal Model;Animals;Anti-viral Therapy;Antibodies;antibody detection;Antibody titer measurement;Biological Assay;Breeding;California;Caribbean region;Chagas Disease;Consensus;COVID-19 pandemic;COVID-19 testing;Data;Decision Making;Development;effectiveness evaluation;efficacy evaluation;Ensure;Equipment;Event;Exposure to;germ free condition;Goals;Grant;Health;Herpesvirus 1;HIV;Human;Human Resources;Immune response;Immunization;Immunization Programs;Immunoassay;Immunology;improved;Infection;instrument;interest;Investigation;Laboratories;Macaca;Macaca mulatta;Maintenance;Measles;Measles virus;member;Methods;Monitor;Monkeys;Mucous Membrane;Oregon;Parasites;pathogen;Pathogen detection;Patients;Pest Control;Prevalence;Primates;Principal Investigator;Procedures;programs;Reagent;Recombinants;Recommendation;Reliability of Results;Research;Research Personnel;Research Support;Reverse Transcriptase Polymerase Chain Reaction;Rhesus;Risk;Sampling;SARS-CoV-2 antibody;screening;Serology;Serology test;Serum;simian human immunodeficiency virus;Simian Retroviruses;SIV;System;Techniques;Testing;Time;Trypanosoma cruzi;U-Series Cooperative Agreements;United States National Institutes of Health;Viral;Viral Pathogenesis;viral RNA;Virus;virus testing;Washington;working group

PROJECT_TITLE: Viral Testing Core


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: Project Narrative In this proposal, we will investigate the role of astrocytes in the dorsal striatum, which regulates goal-directed and habitual ethanol-seeking behaviors in mice. Our study will elucidate the neural mechanisms encoding goal-directed and habitual reward-seeking behaviors. We will provide a rational path for the development of new therapeutic methods for the treatment of alcohol use disorder.

PI_NAMEs: CHOI, DOO-SUP  (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Ablation;addiction;ADORA2A gene;alcohol abuse therapy;alcohol seeking behavior;alcohol use disorder;Alcohols;Astrocytes;Behavior;Behavioral;Calcium;Corpus striatum structure;Data;Decision Making;Development;Dorsal;Ethanol;Event;excitotoxicity;Fiber;Genetic;Globus Pallidus;Glutamates;Goals;Impulsivity;in vivo calcium imaging;Lesion;Measures;Medial;Mediating;Methods;Mus;neuromechanism;Neurons;neurotransmission;Neurotransmitters;Nose;novel therapeutics;Obsessive-Compulsive Disorder;Operant Conditioning;Outcome;Pattern;Photometry;Population;prevent;Process;Psychopathology;Rewards;Role;Shapes;Signal Transduction;Synapses;Synaptic Cleft;System

PROJECT_TITLE: Astrocyte-Neuron Interaction in the Dorsal Striatum and Ethanol-Seeking Behaviors

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Patient Safety;Primary Health Care

PHR: PUBLIC HEALTH RELEVANCE STATEMENT With this K24 award, Dr. Rachel Werner will continue to build her successful research program aimed at improving the delivery of care for older patients with complex and chronic illness and will expand this research to focus on older adults with dementia, a group that is particularly vulnerable and may experience numerous unintended consequences from payment reform. She will use her research as a platform to mentor new investigators in this field and help them to become independent investigators. Taken together, her ongoing and proposed research, coupled with her mentorship program to train outstanding investigators in the field, will help address the critical need to reform the health care delivery system to efficiently bring high quality care to the millions of aging Americans in need of better care.

PI_NAMEs: WERNER, RACHEL M (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: accountable care organization;Achievement;Acute;acute care;Address;Affect;Aging;Alzheimer's disease related dementia;American;Area;Award;bundled payment;Caliber;care costs;care delivery;care giving burden;career;caregiving;Caring;Chronic;Chronic Disease;clinical practice;Complex;cost;Coupled;Data Set;Dementia;design;Disease;experience;experimental study;Frequencies;Funding;Goals;Government;Growth;Health Care Costs;health care delivery;health care disparity;Health Care Reform;Health Policy;Healthcare;Home;Hospitalization;Hospitals;Impact evaluation;improved;Incentives;innovation;insight;Institution;Investigation;Length of Stay;Measurement;Measures;Medicare;Mentors;Mentorship;Methodology;Mid-Career Clinical Scientist Award (K24);Nursing Homes;older adult;older patient;Older Population;Outcome;Patient Care;Patient Discharge;Patient Education;patient oriented;patient oriented research;Patient-Focused Outcomes;Patients;payment;Persons;Policies;Primary Care;programs;Provider;public health relevance;Publishing;Quality of Care;recruit;Research;Research Infrastructure;Research Personnel;Rewards;Skilled Nursing Facilities;System;Training;Training Programs;Use Effectiveness;Work

PROJECT_TITLE: Midcareer Mentoring Award for Patient-Oriented Research in Aging

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: SAN FRANCISCO

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Commensal bacteria critically support skin immune homeostasis, and breakdown of this symbiosis contributes to common chronic inflammatory skin disorders. Greater mechanistic understanding of these processes will lay the groundwork for future therapeutic strategies targeting host-commensal interactions in skin. The proposed translationally oriented studies use innovative approaches to define the role of a specific cell type, type 2 conventional dendritic cells, in cutaneous immune regulation and elucidate the bacterial molecules and host pathways influencing their behavior.

PI_NAMEs: SCHARSCHMIDT, TIFFANY CRAWFORD (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Acne;Animal Model;Antigen-Presenting Cells;Antigens;Atopic Dermatitis;Bacteria;Behavior;Biopsy;CD4 Positive T Lymphocytes;Cell Communication;Cell Physiology;cell type;Cells;Cellular biology;chronic inflammatory skin;commensal bacteria;commensal microbes;Cues;Cutaneous;Data;Dendritic Cells;Detection;dimensional analysis;Disease;Dissection;Engineered skin;Functional disorder;Future;germ free condition;Gnotobiotic;Goals;Hidradenitis Suppurativa;high dimensionality;Homeostasis;Human;human tissue;Immune;Immune Tolerance;immunoregulation;Inflammatory;innate immune pathways;innovation;Left;Ligands;Maintenance;Measures;Mediating;Microbe;microbial community;microbiome;microbiota;mouse model;Mus;mutant;Myeloid Cells;Nature;Neonatal;novel;novel therapeutic intervention;Pathologic;Pathway interactions;Phagocytosis;Phenotype;Population;Positioning Attribute;prevent;Process;receptor;receptor binding;Regulatory T-Lymphocyte;response;Role;Shapes;Signal Transduction;single cell analysis;Site;Skin;skin disorder;skin microbiome;Surface;Symbiosis;System;T-Lymphocyte;Testing;Therapeutic;Tissues;TLR2 gene;tool;Transgenic Animals;Transgenic Mice;uptake;Work

PROJECT_TITLE: Functional Dissection of Regulatory Myeloid Cells in Microbe-Immune Crosstalk in Skin


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE High-performance computational algorithms are the core engines behind the analysis of biological sequence data produced in biomedical research and clinical applications. The proposed studies aim to develop faster and more accurate solutions to fundamental computational problems in bio-sequence analysis. The success of this proposal is likely to accelerate research and applications that utilize high-throughput sequence data.

PI_NAMEs: LI, HENG  (contact)

PROGRAM_OFFICER_NAME: DAYAL, JYOTI

PROJECT_TERMS: Acceleration;Advanced Development;Algorithms;Attention;Bacterial Genome;base;Biological;Biomedical Research;Centromere;clinical application;Code;Complex;Computational algorithm;Computer software;computerized tools;Computing Methodologies;Data;Engineering;Funding;Future;Generations;Genes;genetic pedigree;Genetic Variation;Genome;genome annotation;Graph;Haplotypes;Hi-C;high throughput analysis;High-Throughput Nucleotide Sequencing;human data;improved;insertion/deletion mutation;Label;Length;Mainstreaming;Maps;Medical;Memory;Methods;Modernization;nanopore;Nucleotides;Parents;Performance;Phase;power analysis;Price;Principal Investigator;programs;Proteins;Protocols documentation;Publications;Repetitive Sequence;Research;Resolution;RNA Splicing;Sequence Alignment;spelling;success;Techniques;Technology;tool;Work;Writing

PROJECT_TITLE: Advanced computational methods in analyzing high-throughput sequencing data

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


PHR: Narrative– Core C: MHC Genetic Typing Core This genomics-focused project will characterize the SNPRC SPF rhesus macaque colony to enable breeding strategies that consider genome-wide genetic diversity and fitness of colony members, while still providing rhesus macaques lacking specific MHC I alleles for AIDS researchers.

PI_NAMEs: COLE, SHELLEY A (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;Alleles;Animals;Antigen Presentation;Area;Breeding;Caribbean region;Chinese;Collaborations;Communicable Diseases;Communities;cost effective;Crossbreeding;Data;Disease Progression;Ensure;exome;fitness;Frequencies;Generations;Genetic;genetic pedigree;Genetic Variation;genome sequencing;genome-wide;genomic data;genomic locus;Genomics;Genotype;germ free condition;Haplotypes;HIV;HIV/AIDS;Human;Immune response;Infection;Macaca;Macaca mulatta;Measurement;member;MHC Class I Genes;Modeling;Monitor;nonhuman primate;novel strategies;offspring;Parents;Pathogenesis;Phylogenetic Analysis;pressure;Primates;Research;Research Personnel;Resistance;Resolution;Sampling;Services;Single Nucleotide Polymorphism;SIV;System;T-Lymphocyte;transmission process;United States National Institutes of Health;vaccine effectiveness;Virus;whole genome;Wisconsin;Work

PROJECT_TITLE: MHC Genetics Core


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Cancer;Brain Disorders;Cancer;Mental Health;Neurosciences;Pediatric;Pediatric Cancer;Prevention;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: NARRATIVE Although radiation and chemotherapy-based treatment of central nervous system tumors in young children is highly effective, it can also cause life-long and devastating NI and other toxicities. Despite the clear importance of maximizing post-treatment quality of life for childhood cancer survivors, our understanding of the mechanisms driving therapy-induced neurotoxicity is limited and no clinically-useful mitigators currently exist. By leveraging innovative tools that give us a unique view into cell death regulation in the nervous system, we are clarifying the mechanisms responsible for these effects and identifying treatment strategies that can meaningfully improve outcomes.

PI_NAMEs: SAROSIEK, KRISTOPHER ANDREW (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Adolescent;Adult;Affect;Aftercare;Age;Apoptosis;Apoptotic;Astrocytes;Automobile Driving;BAX gene;Bax protein;BCL1 Oncogene;Biological Models;Birth;Blood capillaries;Blood Vessels;Brain;Brain region;brain tissue;cancer cell;Cancer Etiology;cancer prevention;Cancer Survivor;cancer therapy;Cancerous;Caspase;Cell Cycle Arrest;Cell Death;cell injury;Cell Survival;cell type;Cells;Central Nervous System Neoplasms;Cephalic;Cessation of life;chemotherapy;Chemotherapy and/or radiation;Child;Childhood;childhood cancer survivor;Childhood Central Nervous System Neoplasm;Childhood Malignant Brain Tumor;Clinical;clinical application;Cognitive deficits;conditional knockout;cytochrome c;dentate gyrus;Development;Diagnosis;DNA;DNA Repair;Dose;Exhibits;Exposure to;External Beam Radiation Therapy;Family;Female;Future;Genetic;Goals;Growth;Homeostasis;Human;Impairment;improved;improved outcome;In Vitro;in vivo;Induction of Apoptosis;Inhibition of Apoptosis;innovation;Knock-out;Learning;Life;Life Experience;Long-Term Effects;Maintenance;male;Malignant neoplasm of central nervous system;Measures;Mediating;Medulloblastoma;member;Memory;Microtubules;Modality;Morbidity - disease rate;Motor;mouse model;Mus;Neonatal;nerve stem cell;Nervous System;neural;Neurocognitive;Neurocognitive Deficit;neurogenesis;Neurons;neuroprotection;neurosurgery;neurotoxicity;Normal Cell;Outer Mitochondrial Membrane;Pathway interactions;Patients;pediatric patients;Permeability;pharmacologic;Phenotype;postnatal;prevent;Prevention;Protein Family;Proto-Oncogene Proteins c-myc;Quality of life;Radiation;Radiation therapy;Regulation;Reporting;response;Role;senescence;Severities;Shapes;Signal Pathway;Signal Transduction;stem;stem cells;Stimulus;Stress;Synaptic plasticity;Testing;Thinness;Time;Tissues;tool;Toxic effect;TP53 gene;treatment strategy;tumor;tumorigenesis;Vascular Endothelial Cell;VDAC1 gene;Visual Acuity

PROJECT_TITLE: Developmental regulation of apoptosis as a modifiable driver of radiotherapy-induced neurocognitive impairment in pediatric patients

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Breast Cancer;Cancer;Lung;Women's Health Research

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative  Triple-negative breast cancer (TNBC) cells metastasize by extravasating from blood vessels using mechanisms similar to leukocyte extravasation, which requires endothelial chemokine receptor ACKR1. We will determine the contribution of endothelial ACKR1 to TNBC metastatic progression, the stages of TNBC extravasation affected by overexpression of endothelial ACKR1, and the mechanistic interactions between ACKR1 and CXCL2 in facilitating TNBC extravasation. This proposal will establish the importance of ACKR1 as a potential prognostic indicator in TNBC and provide a research and clinical educational plan to develop the PI for a physician- scientist career in oncology.

PI_NAMEs: ROACH, SAMUEL  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Address;Adhesions;Affect;Antibodies;Binding;Biological;Blood capillaries;Blood Vessels;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Patient;Breast Cancer Treatment;cancer subtypes;career;Cell Adhesion Molecules;cell type;Cells;Cessation of life;chemokine;chemokine receptor;Circulation;Clinical;Coculture Techniques;Control Animal;Copying Processes;CXCL2 gene;cytokine;Data;Development;diagnostic screening;Distant;Distant Metastasis;education planning;Endothelial Cells;Endothelium;Epidermal Growth Factor;Erythrocytes;Estrogen Receptors;Evaluation;Extravasation;Fatty acid glycerol esters;Genes;Human;Implant;improved;in vivo;in vivo imaging system;inhibitor;insight;Intercellular Junctions;Knockout Mice;Leukocytes;Literature;Localized Disease;Lung;Malignant Breast Neoplasm;mammary;Measurement;Mediating;Membrane;Metastatic breast cancer;Metastatic Neoplasm to the Lung;Micrometastasis;migration;Modality;monolayer;mortality;Mouse Cell Line;mouse model;Mus;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;neutralizing antibody;neutrophil;novel;Oncology;overexpression;Patients;Physicians;Physiological;prevent;Primary Neoplasm;Process;Progesterone Receptors;prognostic indicator;Prognostic Marker;Research;Role;Scientist;shear stress;Site;Stromal Cells;Structure of parenchyma of lung;Survival Rate;System;Tail;Testing;Tissues;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor microenvironment;Tumor Promotion;Veins

PROJECT_TITLE: The Role of Endothelial ACKR1 in Triple-Negative Breast Cancer Metastasis


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Over half of current tobacco smokers report a desire to quit, yet due the highly addictive nature of nicotine, it often takes ~10 attempts before individuals successfully quit smoking. This project will use a mouse model of nicotine dependence to characterize how nicotine dependence/withdrawal states and nicotine-predicting cues are represented in the insular cortex – a region of the brain implicated in addiction. By characterizing how the actions of nicotine are encoded in the insular cortex and defining the causal role of this region in nicotine- seeking behaviors, this proposal will give new insight into behaviors relevant to nicotine addiction.

PI_NAMEs: EVANS, KATHRYN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Acute;addiction;Affect;Animals;antagonist;Area;Behavior;Behavioral;behavioral response;bodily sensation;Brain;Brain region;Calcium;cell cortex;Chronic;Cigarette;Clinical;Consumption;craving;Cues;Decision Making;Dependence;Development;Dopamine;drinking water;Drug Addiction;drug development;drug seeking behavior;Esthesia;Expectancy;experience;experimental study;Food;Functional Imaging;Future;Goals;Head;hedonic;Home;Human;Hunger;Image;imaging study;improved;Individual;insight;Intake;Interoception;Learning;Measurement;Mediating;mouse model;Mus;Nature;neural;Neurons;Nicotine;nicotine craving;nicotine cue;Nicotine Dependence;nicotine exposure;nicotine reward;nicotine seeking behavior;nicotine treatment;nicotine use;Nicotine Use Disorder;Nicotine Withdrawal;Nicotinic Receptors;novel;Nucleus Accumbens;optogenetics;Oral;Patient Self-Report;Patients;Pattern;Perception;Peripheral;Pharmaceutical Preparations;pharmacologic;Photometry;Physiological;Physiology;Play;Population;post stroke;Preparation;Protocols documentation;Regulation;Reporting;response;Rewards;Role;Satiation;Sensory;sensory integration;Shapes;Signal Transduction;Smell Perception;Smoker;Smoking;smoking cessation;Stroke;Taste Perception;Testing;Thirst;Time;tobacco smokers;Training;two-photon;Visceral;Visual;Water;Withdrawal;Work

PROJECT_TITLE: Tracking and regulation of nicotine dependence in the insular cortex


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Opioids;Pain Research

PHR: PROJECT NARRATIVE This research evaluates the relationships between prescription opioid use, cognitive outcomes, and changes in brain morphometry in large population-based cohort of community-dwelling older adults, while also assessing their perceptions and experiences regarding the impact of opioids on pain and cognition. Opioid use is common in older adults (prevalence of approximately 10% in those >65 years of age) and may represent a modifiable risk factor for cognitive impairment and dementia. In this research, we will utilize a mixed methods approach, including prospectively-obtained epidemiological and neuroimaging data, and qualitative methodologies to assess the relationships between opioid use and cognition in older adults.

PI_NAMEs: WARNER, NAFISSEH S (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Absence of pain sensation;Acceleration;Adult;advanced analytics;Age Years;Aging;Alzheimer's Disease;Amygdaloid structure;Analgesics;Applications Grants;Area;Attention;Brain;care outcomes;Cerebrum;Chronic;chronic pain;chronic pain management;Clinic;clinical epidemiology;clinically relevant;Cognition;Cognitive;cognitive change;cognitive function;cognitive performance;cognitive testing;cohort;Communities;Confounding Factors (Epidemiology);County;Data;Dementia;Development;Diagnostic;Dose;Enrollment;Epidemiology;epidemiology study;Evaluation;evidence base;executive function;experience;Familiarity;Foundations;functional status;Future;Goals;gray matter;Health;Healthcare;human old age (65+);Image;Impaired cognition;improved;Inferior;Intervention;Interview;Knowledge;Magnetic Resonance Imaging;Measurement;Measures;Memory;mental state;Methodology;Methods;mild cognitive impairment;modifiable risk;morphometry;multidisciplinary;neuroimaging;Neuropsychology;older adult;Opioid;opioid therapy;opioid use;Outcome;Outcome Assessment;Pain;Pain management;pain outcome;Participant;Pathologic;Pathway interactions;Patient-Focused Outcomes;Perception;Population;population based;Population Study;prescription opioid;preservation;Prevalence;prospective;Qualitative Methods;Quality of life;Research;Resources;reward processing;Rewards;Risk;Risk Factors;Safety;Scientist;screening;Structure;Target Populations;Techniques;Testing;Thick;Time;Training;translational physician

PROJECT_TITLE: Prescription opioids, cognitive decline, and Alzheimer's disease in older adults

STUDY_SECTION_NAME: Clinical and Translational Research of Aging Study Section[NIA -T]


ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: The incidence of allergies is steadily increasing world-wide. Despite a large amount of effort, the cellular mechanisms controlling allergic inflammation are not completely known. The proposed studies will identify how follicular T cells control allergic inflammation, providing a framework for new therapeutics to treat allergies.

PI_NAMEs: SAGE, PETER THE (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Adoptive Transfer;Affect;Allergens;allergic airway disease;Allergic Disease;Allergic inflammation;Antibodies;Antibody Response;B-Lymphocytes;Biological Assay;cell motility;Cells;Communication;conditional knockout;counterregulation;Data;Development;dimensional analysis;Disease;Effector Cell;Eosinophilia;Equilibrium;Evolution;Goals;Helper-Inducer T-Lymphocyte;high dimensionality;Hypersensitivity;IgE;Immune response;Immune system;Immunoglobulin Class Switching;Immunoglobulin Somatic Hypermutation;Immunoglobulin Switch Recombination;immunoregulation;In Vitro;in vitro Assay;in vivo;Incidence;Individual;Inflammation;innovation;interleukin-21;Maps;Mediating;Modeling;mosaic;mouse model;Mus;novel;novel therapeutics;Pathogenicity;Plasma Cells;Population;Production;Publishing;Pulmonary Inflammation;Pulmonary Pathology;Reporter;response;Role;Signal Transduction;stem;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Testing;Time;Tissues;tool

PROJECT_TITLE: Humoral Immunoregulation of Allergic Disease by Follicular T Cell Subsets

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(57)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: BATON ROUGE

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: PROJECT NARRATIVE In partnership with the IDeA community, NIGMS IDeA officials and Louisiana State University serving as the Meeting Organizer, this application aims to organize and convene the next three National IDeA Symposium of Biomedical Research Excellence (NISBRE) conferences planned for 2022, 2024 and 2026, to significantly enhance the collaborative interactions among IDeA community and positively impact future funding opportunities.

PI_NAMEs: BEVINS, RICK A;KOUSOULAS, KONSTANTIN G (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Achievement;Area;Award;Basic Science;Behavioral Research;Bioinformatics;Biomedical Research;Businesses;career;career development;Centers of Research Excellence;Clinical;clinical infrastructure;Clinical Research;Collaborations;commercialization;Communication;Communities;community partners;Congresses;Contractor;Data;design;Development;Educational workshop;Eligibility Determination;Emerging Technologies;Faculty;faculty support;falls;Fostering;Funding;Funding Mechanisms;Funding Opportunities;Future;Goals;graduate student;Guidelines;Health;improved;Individual;Information Technology;Infrastructure;infrastructure development;innovation;innovative technologies;insight;Institution;Interdisciplinary Study;interest;lectures;Louisiana;medically underserved;meetings;Mentors;Methodology;National Institute of General Medical Sciences;new technology;Oral;Parents;Participant;Peer Review;Postdoctoral Fellow;Professional Competence;programs;Publishing;Puerto Rico;Recording of previous events;Request for Applications;Research;Research Activity;Research Infrastructure;Research Personnel;response;Scientist;Secure;skill acquisition;skills;skills training;Small Business Innovation Research Grant;Small Business Technology Transfer Research;Students;success;symposium;Teacher Professional Development;Technology;Technology Transfer;Training;Translational Research;translational research program;translational scientist;undergraduate student;underserved community;United States National Institutes of Health;Universities;working group

PROJECT_TITLE: National IDeA Symposium of Biomedical Research Excellence - NISBRE

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative As the burden of neurodegenerative diseases and neurological disorders is high, there is a critical need to develop novel PET ligands to image illness-related biological processes in the brain. This work will develop key imaging tools to advance our understanding of central cholesterol homeostasis and facilitate drug discovery.

PI_NAMEs: LIANG, STEVEN H (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: ABCB1 gene;Affinity;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease therapeutic;Amyloid beta-Protein;antagonist;Autopsy;Autoradiography;Binding;Biochemical Process;Biodistribution;Biological;Biological Assay;Biological Process;Blood specimen;Brain;brain tissue;Carbon Dioxide;Cerebellum;Cessation of life;Characteristics;Chemistry;Cholesterol;cholesterol 24-hydroxylase;Cholesterol Homeostasis;Clinical;clinical translation;Corpus striatum structure;Deposition;design;Development;Disease;Disease Progression;Docking;Dose;drug discovery;Evaluation;Functional disorder;Goals;Human;Huntington Disease;Hydroxycholesterols;Image;image translation;Imaging Device;imaging study;improved;In Vitro;in vitro Assay;in vivo;in vivo evaluation;Kinetics;knockout gene;Label;Lead;Length;Libraries;Ligands;Mediating;Messenger RNA;Modeling;Molecular;Monitor;mouse model;Nervous System Disorder;Neurodegenerative Disorders;Neurofibrillary Tangles;next generation;nonhuman primate;novel;Penetration;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Positioning Attribute;Positron-Emission Tomography;Protein Isoforms;prototype;Radioactivity;Radiolabeled;radioligand;Research;response;Rodent;sample fixation;Schizophrenia;Site;Specificity;Standardization;Testing;Therapeutic;Transgenic Organisms;Translations;United States;uptake;Validation;Work

PROJECT_TITLE: Ligand discovery for delineating cholesterol homeostasis in the brain

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS-R]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Rare Diseases

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Increased incidence/mortality rate of pancreatic cancer raises public health concerns in the United States. Our findings that Engrailed-1 (EN1), a transcription factor, is involved in metastatic transition of pancreatic cancer warrant further investigation for the detailed molecular mechanisms. Better understanding of how EN1 makes pancreatic cancer cells aggressive can lead to novel avenues for the treatment of this deadly disease.

PI_NAMEs: HWANG, CHANG-IL  (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Abbreviations;Acceleration;Address;Alleles;Automobile Driving;Biomimetics;Biopsy;bisulfite sequencing;Blood Vessels;California;cancer cell;cancer type;carcinogenesis;Characteristics;ChIP-seq;chromatin immunoprecipitation;chromatin remodeling;Coculture Techniques;Complex;Comprehensive Cancer Center;conditional knockout;Data;Data Analyses;Death Rate;Development;Disease;Disease Progression;Disseminated Malignant Neoplasm;DNA Methylation;effective therapy;Endometrial Carcinoma;Endowment;Enhancers;Epigenetic Process;epigenome;Epithelium;gain of function;Gene Expression;Gene Expression Regulation;Gene set enrichment analysis;Genes;genetic signature;Genetic Transcription;Genetically Engineered Mouse;Glioma;homeodomain;Human;improved;In Vitro;in vivo;Incidence;Injections;insight;Invaded;Investigation;loss of function;Lung;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Mesenchymal;Modeling;Molecular;molecular subtypes;mouse model;Mus;Nature;Neoplasm Metastasis;neurodevelopment;next generation sequencing;novel;novel therapeutic intervention;Organoids;Pancreas;pancreatic cancer cells;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pancreatic Intraepithelial Neoplasia;Pathway interactions;patient derived xenograft model;Patients;Play;Process;Prognosis;Property;Public Health;recruit;Renal Carcinoma;Resected;Resistance;Role;Sampling;single-cell RNA sequencing;Solid Neoplasm;Stomach;Surgical Models;System;Tail;The Cancer Genome Atlas;Therapeutic;Thyroid Gland;trait;transcription factor;Transcription Repressor;transcriptome sequencing;transcriptomics;transplant model;treatment response;tumor progression;Tumor-Derived;United States;Universities;Urothelium;Veins

PROJECT_TITLE: Engrailed-1 and Epigenetic Vulnerabilities in Metastatic Pancreatic Cancer

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: PROJECT NARRATIVE With aging, there is increased stiffness of the large arteries (i.e., the aorta and carotid arteries) and stiffer large arteries are associated with Alzheimer’s disease and problems with memory. The proposed studies will determine, for the first time, the cause-and-effect relation between large artery stiffness and impairments in the brain. The knowledge gained from these studies will help identify new methods to prevent or treat Alzheimer’s disease.

PI_NAMEs: WALKER, ASHLEY ELIZABETH (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: abeta accumulation;Abeta synthesis;Advanced Glycosylation End Products;Affect;age related;Aging;aging brain;Alzheimer's Disease;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Aorta;Area;arterial stiffness;Arteries;arteriole;Attenuated;attenuation;Blood capillaries;Blood flow;Blood Pressure;Blood Vessels;blood-brain barrier permeabilization;Brain;candidate identification;Carotid Arteries;cerebral artery;cerebral microbleeds;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;cerebrovascular reactivity;Cerebrovascular system;Clinical Research;Collecting Cell;Data;Dementia;Development;Disease;Elastin;Elderly;endothelial dysfunction;Functional disorder;Future;Gene Expression;Goals;Hemorrhage;human subject;Impaired cognition;Impairment;inhibitor;innovation;Intervention;Knowledge;Late Onset Alzheimer Disease;Lead;Learning;Link;Measures;Memory;Memory impairment;Methods;Modeling;mouse model;Mus;Mutation;Nerve Degeneration;neuroinflammation;Neurons;neuropathology;new therapeutic target;novel;old mice;Oxidative Stress;Pathology;pharmacologic;Phenotype;presenilin-1;pressure;Prevalence;prevent;Prevention;Pulse Pressure;Pyridoxamine;Research;Risk;Risk Factors;Role;Source;Testing;Therapeutic;Thinness;Time;Tissues;transcriptome;transcriptome sequencing;Transgenic Mice;Vascular Diseases;Vascular Endothelial Cell;Wild Type Mouse

PROJECT_TITLE: Large artery stiffness and cerebrovascular dysfunction: Implications for cognitive impairment and neuropathology

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Cardiovascular;Hematology

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Deep venous thrombosis (DVT, clots that form in the deep veins of the arms or legs) and its complication, pulmonary embolism, is the third leading cardiovascular cause of death in the United States. Although inflammation is increasingly recognized as a precursor to the development of venous thrombosis, treatments for DVT do not treat inflammation. This proposal examines a natural mechanism by which an enzyme that coats cells in the bloodstream protects against DVT by dispersing harmful inflammatory molecules involved in clot formation and extension, with the ultimate goal of developing more effective and safe treatment approaches in this devastating disease.

PI_NAMEs: PINSKY, DAVID J. (contact)

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: Affect;American;arm;Autocrine Communication;Automobile Driving;Blood Cells;Blood Circulation;Blood Platelets;Blood Vessels;Cardiovascular Diseases;Cardiovascular system;Cause of Death;Cell Adhesion Molecules;Cell Lineage;Cells;Cessation of life;Chromatin;Clinical Trials;Coagulation Process;Complication;cytokine;Data;deep vein;Deep Vein Thrombosis;Defense Mechanisms;Deposition;Development;Disease;ecto-nucleotidase;Electron Microscopy;Endothelium;Environment;Enzymes;Erythrocytes;experimental study;extracellular;Feedback;Fiber;Fibrin;Gene Deletion;Gene Modified;Generations;Glycocalyx;Goals;Homeostasis;Hydrolysis;Immune;immune activation;improved;In Vitro;in vivo;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;injured;Innate Immune Response;insight;Interleukin-1 beta;Interruption;Kinetics;Leg;leukocyte activation;Leukocytes;Macrophage;Mediating;microvesicles;Modeling;Molecular;mouse model;Mus;Myelogenous;Myeloid Cells;Natural Immunity;Neurofibrillary Tangles;neutrophil;Nucleotides;Paracrine Communication;particle;Phenotype;phosphodiester;Platelet aggregation;Process;Pulmonary Embolism;recruit;Regulation;response;restraint;Role;Signal Transduction;Structure;Surface;Testing;Therapeutic;Thrombin;thrombogenesis;thromboinflammation;Thrombosis;thrombotic;Thrombus;United States;Venous;venous thromboembolism;Venous Thrombosis;Work

PROJECT_TITLE: Purinergic regulation of Innate Immunity to promote Venous Homeostasis

STUDY_SECTION: HT

STUDY_SECTION_NAME: Hemostasis and Thrombosis Study Section.  Committee was terminated on 11/30/2020. [HT]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: BALTIMORE

ORG_DEPT: BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative  Retinal Ganglion Cells (RGCs) transmit visual information from the eye to the brain and their death or degeneration contributes to glaucoma and blindness. While different subtypes of RGCs have been characterized in model organisms, RGC subtype diversity in the human retina is poorly described. This project aims to define the RGC subtypes of the human retina by gene expression and morphology, and identify mechanisms that generate RGC diversity in human retinal organoids.

PI_NAMEs: GUY, BRIAN  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Adult;Axon;Biological Assay;Biological Models;Blindness;Brain;cell type;Cellular biology;Cessation of life;Classification;Clustered Regularly Interspaced Short Palindromic Repeats;Code;combinatorial;Data;Development;Dyes;Ectopic Expression;experimental study;Eye;Fluorescent Dyes;Gene Expression;Gene Expression Profile;Generations;Genetic Complementation Test;Glaucoma;Goals;Human;human tissue;Immunohistochemistry;in vivo;insight;Interneurons;Knock-out;Label;lipophilicity;Macaca;model organism;Modeling;Molecular;Molecular Profiling;Morphology;Mus;Mutagenesis;neuronal cell body;Neurons;Organoids;pharmacologic;Photoreceptors;Play;Population;Primates;Protocols documentation;Publishing;Radial;regenerative therapy;Reporter;Retina;Retinal Diseases;Retinal Ganglion Cells;retinal neuron;RNA;Role;Science;single-cell RNA sequencing;Sorting;Specific qualifier value;Stains;stem cell organoids;Stratification;Testing;Time;transcription factor;Transfection;transmission process;Viral;visual information;Work

PROJECT_TITLE: Retinal Ganglion Cell Subtype Specification in Human Retinal Organoids

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-U(20)L]


PHR: Project Narrative The proposed research is relevant to public health because chromosomes are missing or an extra chromosome is present in 10-30% of human conceptions. The majority of these chromosomal abnormalities are caused by defects during female meiosis and these chromosomal abnormalities lead to embryonic death or cognitive disability. The proposed research will reveal mechanisms that may cause these abnormalities in humans and will suggest ways to prevent them.

PI_NAMEs: MCNALLY, FRANCIS J (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TITLE: Mechanisms of Asymmetric Cell Division During Female Meiosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Hematology;Human Genome;Infectious Diseases;Precision Medicine;Sepsis

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Sepsis is a prevalent and life-threatening disease of humans characterized by organ dysfunction that is due to an overly aggressive immune response to an infection; despite the importance of this disease, currently there are no diagnostic methods that can rapidly and accurately identify patients that have this disease. Our goals are to identify and characterize biomarkers in sepsis and to gain insights into the mechanisms leading to inappropriate immune responses. We will do this by applying state-of-the-art technology in ways that have not been used previously to analyze individual immune cells in the blood of patients with sepsis; the insights gained from the proposed work have the potential to lead to rapid diagnostic tools for sepsis.

PI_NAMEs: FILBIN, MICHAEL ;GOLDBERG, MARCIA B (contact);HACOHEN, NIR

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Accident and Emergency department;Acute;Address;Advanced Development;Affect;Antibodies;Bacteremia;Bar Codes;Biological Markers;Biology;biomarker identification;biomarker panel;Blood;Blood Cells;Blood Vessels;Cell Physiology;Cell surface;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clinical;clinically relevant;cohort;Data;Data Set;Development;Diagnostic;Diagnostic Procedure;diagnostic tool;Disease;Early Diagnosis;effective therapy;Endothelium;Etiology;Exhibits;Extravasation;Flow Cytometry;Functional disorder;Future;Gene Expression Profile;Gene Expression Profiling;gene function;Genes;genomic profiling;Goals;Health;Heterogeneity;Human;Human body;human disease;Immune;Immune response;Immune System Diseases;improved;in silico;Individual;Infection;insight;Intervention;Investigation;Life;Longitudinal cohort;Maps;Measures;Membrane Proteins;Modeling;Molecular;Molecular Profiling;monocyte;Mus;Nature;new therapeutic target;novel therapeutics;Organ;Outcome;Pathway interactions;patient stratification;patient subsets;Patient-Focused Outcomes;Patients;Phenotype;Pilot Projects;predictive marker;Proteome;Rapid diagnostics;Resolution;response;Risk;Role;Sampling;Sepsis;septic patients;Signs and Symptoms;single cell genomics;single-cell RNA sequencing;Site;Stimulus;Surface;Syndrome;Technology;Testing;Therapeutic;therapeutic development;transcriptome;transcriptomics;Translating;Urinary tract infection;Validation;Variant;Vascular Endothelial Cell;Vascular Permeabilities;Work

PROJECT_TITLE: Single-cell genomic profiling to identify immune signatures of bacterial sepsis in humans

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Lung;Lung Cancer

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Project Narrative  There is a significant need to translate our understanding of ferroptosis mechanisms into effective cancer therapies. The objective of this application is to determine the role and mechanisms of AMP-activated protein kinase (AMPK), a critical sensor of cellular energy status, in regulating ferroptosis and the relevance of these regulatory functions to tumor suppression and treatment. Our proposed studies will have significant impact on both our basic understanding of ferroptosis and our ability to target AMPK or ferroptosis in cancer treatment.

PI_NAMEs: GAN, BOYI  (contact)

PROGRAM_OFFICER_NAME: SALNIKOW, KONSTANTIN

PROJECT_TERMS: 5'-AMP-activated protein kinase;Acetyl Coenzyme A;Acetyl-CoA Carboxylase;Anabolism;Antineoplastic Agents;Apoptosis;cancer cell;cancer therapy;Cell Death;Cell Death Induction;Coenzyme A;Communities;Complex;CRISPR screen;Data;Development;fatty acid biosynthesis;Goals;Homeostasis;in vivo;innovation;interest;Iron;KRAS2 gene;Link;Lipid Peroxidation;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Malonyl Coenzyme A;Mediating;Modality;Morphology;mouse model;mutant;novel;novel therapeutic intervention;Outcome;Pathway interactions;Phosphorylation;Polyunsaturated Fatty Acids;pre-clinical;Production;protein kinase inhibitor;Publications;Regulation;Resistance;Role;sensor;Signal Pathway;Signal Transduction;Stress;targeted agent;Testing;Therapeutic;therapeutic target;therapeutically effective;TP53 gene;Translating;tumor;Tumor Biology;Tumor Promotion;Tumor Suppression

PROJECT_TITLE: Targeting ferroptosis in cancer therapy

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT SUMMARY - UNIVERSITY OF NORTH CAROLINA-CHAPEL HILL, FROHLICH The proposed research is relevant to public health since establishing the causal role of network dynamics during sustained attention will ultimately enable the design of novel brain stimulation treatment strategies for impairment of sustained attention, which is common in psychiatric illnesses. Thus, the proposed research is relevant to the NIH’s mission to foster innovative research strategies to improve human health.

PI_NAMEs: FROHLICH, FLAVIO  (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Agreement;Animals;Area;area striata;Attention;Attention deficit hyperactivity disorder;attentional control;Behavioral;Bipolar Disorder;Brain;Cognition;Cognitive;cognitive control;cognitive function;Communities;Cortical Synchronization;Data;design;Development;Dimensions;Electrophysiology (science);Exhibits;Ferrets;Fostering;Frequencies;Health;Human;Impairment;improved;Individual;innovation;interest;Investigation;Lateral;Lateral posterior nucleus of thalamus;Mental Depression;Mental disorders;Mission;Modeling;neural;Neurons;Neurosciences;North Carolina;novel;novel diagnostics;novel therapeutic intervention;optogenetics;Parietal Lobe;Pattern;Performance;Periodicity;Play;Prefrontal Cortex;Process;Public Health;Publishing;Reaction Time;Research;Resources;Rodent;Role;Schizophrenia;sensory input;Signal Transduction;Site;Stimulus;Structure;sustained attention;Task Performances;Testing;Thalamic structure;Therapeutic;treatment strategy;United States National Institutes of Health;Universities;Visual;Visual Perception;Work

PROJECT_TITLE: Targeted circuit modulation to delineate the causal role of oscillatory interactions in top-down networks of cognitive control

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Lung;Pulmonary Hypertension;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: PEDIATRICS

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Pulmonary hypertension (PH) is a fatal disease caused when cells called “neointima” overgrow in the arteries of the lung, no available treatments target this cellular overgrowth, largely because we know very little about neointimal cells including why and how this overgrowth occurs. In these experiments we are 1) pinpointing which cells in the neointima are growing, 2) identifying the signals those cells receive from their neighbors, and 3) using drugs and genetic tests to block those signals to see if it stops neointimal growth. We hope that these experiments will lead to a new generation of therapies that improve the lives of people with PH.

PI_NAMEs: KUMAR, MAYA ELISE (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Ablation;Address;Adult;Affect;Arteries;Automobile Driving;beta catenin;Bioinformatics;bioinformatics tool;Biological Models;Biology;candidate identification;Cell division;cell type;Cells;cellular targeting;Cessation of life;Child;Consensus;Data;Data Set;Development;Disease;drug isolation;drug testing;Drug usage;effective therapy;Endothelial Cells;Endothelium;experimental study;Gene Expression;Gene Expression Profile;Generations;Genetic;genetic testing;Genetic Transcription;Genomics;Growth;Growth and Development function;hemodynamics;Human;improved;In Situ;in vivo;inhibitor;Knowledge;Lesion;Location;Lung;Lung Diseases;Modeling;Molecular;Molecular Profiling;Morbidity - disease rate;mortality;mouse genetics;Mus;neointima formation;notch protein;NOTCH3 gene;novel;Pathology;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Positioning Attribute;prevent;Process;Proliferating;pulmonary arterial hypertension;Pulmonary artery structure;Pulmonary Hypertension;Pulmonary Vascular Resistance;Rattus;right ventricular failure;Rodent Model;Role;Sampling;Signal Pathway;Signal Transduction;single cell analysis;single cell genomics;single-cell RNA sequencing;Supportive care;Technology;Testing;Tissues;Transgenic Mice;Vascular remodeling;Vascular resistance;Vasodilator Agents;WNT Signaling Pathway

PROJECT_TITLE: Defining the cellular and molecular mechanisms driving neointimal lesion growth in pulmonary hypertension

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Biomedical Imaging;Chronic Pain;Clinical Research;Osteoarthritis;Pain Research

PHR: NARRATIVE Osteoarthritis (OA) is a leading cause of pain, reduced joint function, and disability, that reduces productivity and quality of life at tremendous cost to society. Diagnostic imaging of OA is limited by methods that largely assess late-stage disease changes or require longitudinal scanning and are performed in a static fashion that has limited sensitivity to joint function in response to loading from everyday tasks such as walking or climbing stairs. This work aims to develop a novel imaging “stress test”, based on [18F]NaF PET-MRI, that is able to evaluate at a single time point, both the function of the whole-joint unit from physiological joint loading and multiple early markers of OA.

PI_NAMEs: KOGAN, FELIKS  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Acute;Affect;Age;age related;Aging;Area;Bilateral;Biomechanics;bone;Bone Matrix;bone metabolism;Cartilage;Chondrocytes;clinical translation;Clinical/Radiologic;cost;Degenerative Disorder;Degenerative polyarthritis;Deposition;Detection;Deterioration;Development;Diagnostic Imaging;disability;Disease;Disease Progression;Dose;Early Diagnosis;Environment;Evaluation;Exercise stress test;Functional disorder;Future;Gender;Human;Hybrids;Image;Image Analysis;imaging facilities;imaging modality;Imaging technology;Incidence;Injections;innovation;interest;Intervention;Ions;joint function;joint loading;Joints;kinetic model;Kinetics;Knee;Knee Injuries;Knee Osteoarthritis;knee pain;Longitudinal Studies;Machine Learning;Magnetic Resonance Imaging;Measurement;Measures;Meniscus structure of joint;Metabolic;Methods;mineralization;Modeling;Morphology;Motion;Musculoskeletal;Nature;novel;Obesity;older adult;Orthopedics;Pain;Pathogenesis;Patients;Perfusion;Phenotype;Physiological;Physiology;Play;Positron-Emission Tomography;Predisposition;Productivity;Protocols documentation;Quality of life;radiological imaging;radiotracer;Recording of previous events;Research;response;Risk;Risk Factors;Role;Scanning;Severities;sex;Societies;Sodium Fluoride;soft tissue;Stress;Stress Tests;Structure;System;Techniques;Time;Tissues;tool;Translations;uptake;Walking;Work

PROJECT_TITLE: Imaging of Joint Response to Physiological Stress with Age, Sex and in Osteoarthritis

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]