ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_DEPT: ORTHOPEDICS

PHR: Narrative The Michigan Integrative Musculoskeletal Health Core Center will advance healthcare by providing outstanding, state-of-the-art resources and training to enable, enhance, accelerate, and expand the high quality cutting edge research programs of our large well-funded research community. The enrichment program promotes community and inter-disciplinary scholarship to advance novel and emerging science focused on sex specific differences and interactions among musculoskeletal tissues.

PI_NAMEs: JEPSEN, KARL J (contact)

PROGRAM_OFFICER_NAME: GARCIA-CAZARIN, MARY

PROJECT_TERMS: Acceleration;Accounting;Adult;age difference;age related;Artificial Intelligence;Basic Science;Biological Assay;bone;Budgets;Cartilage;Center Core Grants;Chronic;Clinical;Clinical Research;clinically relevant;Collaborations;Communication;Communities;community building;Comprehensive Health Care;Critical Thinking;Data Analyses;Data Analytics;Dentistry;Developed Countries;disability;Discipline;Disease;Education;Effectiveness;Engineering;Environment;Experimental Designs;flexibility;Foundations;Funding;Funding Agency;Goals;Growth;Health;Health Promotion;Healthcare;Healthcare Systems;Histology;Home;hospital care;Individual;Injury;innovation;Institution;Interdisciplinary Study;interest;Leadership;Life Cycle Stages;life span;Ligaments;Machine Learning;medical attention;Medicine;member;Mentorship;Michigan;Mission;Molecular;Muscle;Musculoskeletal;Musculoskeletal Diseases;musculoskeletal injury;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;novel;operation;Organ;Outcome;outreach program;Prevalence;Prevention;programs;Public Health;Reproducibility;Research;Research Personnel;Research Support;Resources;Risk;Scholarship;Science;Scientist;Series;Services;sex;Sex Differences;Structure;System;Talents;Techniques;Technology;Tendon structure;Tissues;Training;Translational Research;United States;United States National Institutes of Health;Universities

PROJECT_TITLE: Michigan Integrative Musculoskeletal Health Core Center (Overall Application)


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Immunotherapy;Orphan Drug;Rare Diseases

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative We have identified WRN as a synthetic lethal target for MSI cancers. This research proposal seeks to investigate why WRN is required in MSI cancers, inform rational drug design, and investigate the relationship between the innate immune response and the DNA-damage response following WRN depletion in cancers with MSI. The overarching goal of this project is to enable the translation of our discovery into a clinically-meaningful therapeutic.

PI_NAMEs: CHAN, EDMOND  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Address;Advisory Committees;Affect;antitumor effect;Apoptosis;Award;Bass;Biochemical;Biological Assay;Biology;cancer cell;cancer type;career;career development;Cell Cycle Arrest;Cell Survival;Cells;Cellular Assay;ChIP-seq;Clinical;Collaborations;Colon Carcinoma;Coupled;Cyclic GMP;Dana-Farber Cancer Institute;Data;Deletion Mutation;Dependence;Development;Dinucleoside Phosphates;Dinucleotide Repeats;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Pathway;DNA replication fork;DNA Structure;Drug Design;drug discovery;Drug usage;Endometrial Carcinoma;Essential Genes;functional genomics;Funding;Genetic;Genetic Transcription;Genomics;Goals;helicase;immune checkpoint blockade;Immunotherapy;Impairment;in vivo Model;Inflammatory Response;inhibitor;Innate Immune Response;Interferons;Knock-out;Laboratory Study;Length;Lysine;Malignant neoplasm of ovary;Malignant Neoplasms;malignant stomach neoplasm;Measures;Medical Oncologist;Mentors;Microsatellite Instability;Microsatellite Repeats;Mismatch Repair;Modeling;Molecular Biology;Mus;Mutate;new combination therapies;novel;novel therapeutics;Nuclear;Pathway interactions;Patients;Phosphorylation;Phosphotransferases;Physicians;Play;Positioning Attribute;Post-Translational Protein Processing;prevent;programmed cell death protein 1;programs;rational design;Repetitive Sequence;replication stress;Reporter;Research Personnel;Research Proposals;Resistance;response;Role;Scientist;Serine;Signal Transduction;skills;Stimulator of Interferon Genes;Structure;Structure-Activity Relationship;Techniques;Testing;Therapeutic;Threonine;TNF gene;Toxic effect;Training;Translations;Tyrosine;WRN gene

PROJECT_TITLE: Advancing WRN as a synthetic lethal target for microsatellite unstable cancers

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PROJECT_TERMS: Acceleration;Achievement;Address;age difference;Biological Assay;Biology;bone;Budgets;career development;Cartilage;Center Core Grants;Clinical;Collaborations;college;Communication;Communities;community building;Complex;Data Analytics;Dentistry;Development;Direct Costs;Discipline;Disease;Education;Effectiveness;Engineering;Evaluation;Feedback;flexibility;Fostering;Funding;Genomics;Geography;Goals;Grant;Health;Healthcare;Healthcare Systems;Histology;Home;hospital care;Injury;innovation;Institution;Interdisciplinary Study;Laboratories;Laboratory Personnel;Leadership;Ligaments;Medicine;meetings;member;Mentorship;Michigan;Mission;Molecular;Muscle;Musculoskeletal;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;new technology;novel;operation;Outcome;outreach program;Productivity;programs;Research;research and development;Research Personnel;Research Support;Resources;Scholarship;Schools;Science;Scientist;Services;sex;Sex Differences;Structure;success;synergism;Technology;Tendon structure;Tissues;Training;Translational Research;United States National Institutes of Health;Universities;virtual

PROJECT_TITLE: Administrative Core - Core A


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Chronic Fatigue Syndrome (ME/CFS);Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Infectious Diseases;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

ORG_CITY: LONDON

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: LONDON SCH/HYGIENE & TROPICAL MEDICINE

ORG_ZIPCODE: WC1E 7HT

PHR: PROJECT NARRATIVE This is, to our knowledge, the first study to investigate the role of human herpesvirus reactivation in a large cohort of people with ME/CFS (presenting mild/moderate or severe symptoms) in comparison to healthy controls, as well as people with Long COVID and people who fully recovered after COVID-19. Our data and sample collection includes clinical phenotype (including symptom severity), markers of viral reactivation, and immune profiling. Our preliminary findings suggest a correlation between herpesvirus reactivation and symptomology in ME/CFS, particularly related to symptom severity; this proposed study and planned combined clinical and lab-based analyses aims to further clarify whether herpesvirus reactivation induces the aggravation of symptoms or is a consequence of underlying immune dysregulation.

PI_NAMEs: CLIFF, JACKIE ;LACERDA, ELIANA  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: 2019-nCoV;Acute;Adult;Affect;Antigen Presentation;Antigen-Presenting Cells;antigen-specific T cells;Bacterial Infections;biobank;Biological;Biological Assay;Blood;Blood specimen;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Characteristics;Chemical Exposure;Chronic Fatigue Syndrome;Clinical;Clinical assessments;clinical phenotype;cohort;Collecting Cell;Collection;comparison group;Consent;COVID-19;Cryopreservation;Data;Data Collection;design;Development;Diagnosis;diagnostic criteria;Diagnostic tests;digital;Disease;Disease remission;DNA;Endocrine;Enrollment;epidemiology study;Etiology;Event;Evidence based treatment;Exclusion Criteria;Exertion;Family member;Fatigue;Flow Cytometry;follow-up;Frequencies;Funding;Gene Expression Profiling;Goals;Herpesviridae;HHV-6B;Human;Immune;Immune response;Immunity;Immunologic Surveillance;Immunologics;Immunosuppression;inclusion criteria;Individual;Infection;Interferon Type II;Interleukin-2;Intervention;Knowledge;Laboratories;latent infection;Life;Long COVID;longitudinal analysis;Macrophage;Measures;monocyte;multiple sclerosis patient;Mycoses;Nature;neural;Outcome;Participant;Pathogenesis;Patient Recruitments;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Pilot Projects;post SARS-CoV-2 infection;Post-Acute Sequelae of SARS-CoV-2 Infection;Predisposition;Prognostic Marker;Proteins;Protocols documentation;Recontacts;recruit;Recurrence;Relapse;Research Project Grants;RNA;Role;Saliva;saliva sample;Salivary;sample collection;Severities;Severity of illness;stem;Stress;stressor;study population;Symptoms;Syndrome;System;T cell response;T-Lymphocyte;Testing;Time;TNF gene;United States National Institutes of Health;vaccine development;vaccine immunotherapy;Viral;viral DNA;Viral Markers;Viral Proteins;viral RNA;Virus;Virus Diseases;Work

PROJECT_TITLE: Human Herpesvirus 6B in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome pathogenesis: temporal analysis of viral reactivation and immunity to elucidate cause vs effect

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CFS-N(80)S]


ADMINISTERING_IC: AT

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Early life adversity—reported by over 25% of the US population—is thought to program biological adaptations to stress that contribute to life-long health disparities, including increased risk for chronic disease and early mortality. Interventions to offset these risks in adulthood are needed; mindfulness meditation interventions have been effective for reducing stress and improving markers of physical health, but whether they are acceptable and effective for improving health among people with a history of ELA remains unclear. From a public health perspective, establishing an evidence base for remote, just-in-time mindfulness interventions may help to address health disparities in a wide population.

PI_NAMEs: LINDSAY, EMILY  (contact)

PROGRAM_OFFICER_NAME: BAUMGARTNER, JENNIFER NICOLE

PROJECT_TERMS: acceptability and feasibility;active control;Address;Adherence;Adult;Autoimmune Diseases;Benchmarking;Biological;biological adaptation to stress;Biological Markers;Biological Process;Biology;Blood specimen;Buffers;Cardiometabolic Disease;career;career development;Cellular Phone;Childhood;Chronic;Chronic Disease;Collaborations;Complementary Health;coping;Coping Skills;Data;Data Collection;Dedications;design;Development Plans;disorder risk;early life adversity;Educational Intervention;emerging adult;emotional neglect;emotional trauma;Evaluation;evidence base;Evidence based intervention;experience;Exposure to;Fatigue;follow-up;Functional disorder;Future;Goals;Health;health disparity;health training;Heart Rate;IL8 gene;improved;Inflammatory;inflammatory marker;Interleukin-10;Interleukin-6;Intervention;intervention delivery;Life;life span;Life Stress;Link;Location;machine learning model;Measures;Mental Health;Mentors;Mentorship;Methodology;Methods;mindfulness;mindfulness intervention;mindfulness meditation;Mindfulness Training;mobile computing;mobile sensor;Modeling;mortality;National Center for Complementary and Integrative Health;new technology;novel;Outcome;Outcome Assessment;Participant;Pathway interactions;Patient Self-Report;Persons;physical conditioning;Physiological;Population;Populations at Risk;post intervention;predictive modeling;Process;programs;Psychological Tests;psychosocial;Public Health;Race;Randomized;Recording of previous events;recruit;Reporting;Research;Risk;Risk Factors;risk prediction;Sampling;sensor;skills;socioeconomics;Stress;stress reactivity;stress reduction;Surveys;systemic inflammatory response;Technology Assessment;Testing;Time;TNF gene;Training;wearable device;Work;young adult;Youth

PROJECT_TITLE: Smartphone-based mindfulness training for health following early life adversity


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

PI_NAMEs: KOHN, DAVID H. (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Affect;Biological;Biological Assay;biomedical imaging;Blood Vessels;bone;Cartilage;Cells;Cellular biology;Center Core Grants;Chemistry;Clinic;Collaborations;Communication;Communities;cost;Data;Data Analyses;Development;Disease;Education;Education and Outreach;Engineering;Ensure;Experimental Designs;Fee-for-Service Plans;functional outcomes;Future;Gene Expression;Genetic;Goals;Health;High Resolution Computed Tomography;Histologic;Histology;Image;Image Analysis;improved;innovation;instrument;Interdisciplinary Study;Knowledge;Laboratories;Leadership;Length;Link;Measures;Mechanics;Michigan;microCT;Molecular;Morphology;Musculoskeletal;nano;nanoscale;Needs Assessment;neural network;Organ;Outcome;Perfusion;physical science;Physiological;Process;programs;Protocols documentation;Raman Spectrum Analysis;Recommendation;Recording of previous events;repository;Reproducibility;Research;Research Personnel;Research Support;Resources;response;Science;Services;Standardization;Structure;Surveys;Technology;Testing;Tissues;tool;Training;trait;Translating;treatment strategy;Universities;virtual;X-Ray Computed Tomography

PROJECT_TITLE: Structure, Composition, & Histology Core - Core B


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative We propose to develop interpretable and robust deep learning methods for supervised analysis of single cell RNA-seq data or spatial transcriptomic data. Our methods and data analysis results will help translate the rich information in single cell RNA-seq or spatial transcriptomics data into knowledge of biology and potentially actionable conclusions to improve human health.

PI_NAMEs: SUN, WEI  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Address;Algorithms;allograft rejection;Basic Science;Biological;Biological Process;Biology;Biomedical Research;Black Box;Cell Communication;cell type;Cells;Cellular Morphology;Classification;Clinical;clinical practice;Clinical Research;Computer software;Computing Methodologies;cost;COVID-19 patient;Data;Data Analyses;data modalities;Data Set;data to knowledge;deep learning;deep learning model;denoising;design;Development;dimension reduction;Dimensions;Disease;disease diagnosis;Evaluation;expectation;Face;flexibility;Foundations;Gene Expression;Genes;Genomics;Goals;graph neural network;Health;heart allograft;Hematoxylin and Eosin Staining Method;Heterogeneity;high dimensionality;histological image;histological stains;Homeostasis;Human;Image;improved;Individual;Inherited;Knowledge;Label;Learning;Life;Logistics;Malignant Neoplasms;Medical;Methods;Modeling;Molecular;multidimensional data;neural network;Neurodegenerative Disorders;Noise;open source;Organism;Outcome;Patients;Phenotype;Prevention;public repository;Research Project Grants;Sample Size;Sampling;Science;Signal Transduction;single cell analysis;single-cell RNA sequencing;Spottings;Stains;Statistical Methods;success;supervised learning;Techniques;Tissues;tool;Training;training data;transcriptome sequencing;transcriptomics;Translating;Trust;tumor;Update;whole slide imaging;Work

PROJECT_TITLE: Statistical Methods for RNA-seq Data Analysis

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

ORG_STATE: MA

PHR: Antibodies represent some of the most important tools in biology and medicine, which are used to detect and perturb molecular targets for research, diagnostics and therapeutics. Here we propose a new method to engineer and use nanobodies, a small form of antibody, in a massively parallel method against proteins relevant to cancer, thus making affordable antibody development accessible to any investigator.

PI_NAMEs: HACOHEN, NIR  (contact)

PROGRAM_OFFICER_NAME: KYI, CINDY WIN

PROJECT_TERMS: Affinity;Animals;anti-cancer research;Antibodies;antibody detection;antibody engineering;antibody libraries;Antibody Specificity;Antigens;Area;Artificial Membranes;Bacteria;Bacteriophages;Bar Codes;Binding;Biological Assay;Biology;Cancer Biology;cancer cell;Cancer cell line;Cancer Detection;cell dimension;cell growth;Cell surface;Cell Surface Proteins;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Communities;Complex;Consumption;cost effective;cost efficient;CRISPR/Cas technology;Cytometry;Dependence;design;Detection;detection method;Development;Diagnostic;DNA Library;DNA Sequence;empowerment;Engineering;Ensure;Epitopes;Family;flexibility;G-Protein-Coupled Receptors;Generations;Genotype;high dimensionality;High-Throughput Nucleotide Sequencing;Human;in situ sequencing;In Vitro;indexing;Individual;Integral Membrane Protein;interest;Knock-out;Libraries;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Measurement;Measures;Medicine;Membrane Proteins;method development;Methodology;Methods;Molecular Target;nanobodies;Nanotechnology;new technology;novel;novel strategies;nucleic acid detection;Nucleic Acid Hybridization;Open Reading Frames;Phenotype;Production;protein profiling;Proteins;Proteome;Proteomics;Rapid screening;Reagent;receptor binding;Research Personnel;Resources;Ribosomal RNA;Ribosomes;RNA Sequences;SARS-CoV-2 spike protein;screening;single cell sequencing;Slide;Solubility;Specificity;Surface;System;Targeted Research;Technology;Testing;Therapeutic;Time;Tissues;tool;Validation;Virus

PROJECT_TITLE: Development of methods for highly multiplexed quantification of cancer proteomes using large-scale nanobody libraries


NIH_SPENDING_CATS: Bioengineering

PI_NAMEs: MICHELE, DANIEL E (contact)

PROJECT_TERMS: Address;Affect;Age;Animal Model;Animals;Attention;base;Basic Science;Biology;Biomechanics;Biophysics;bone;Cartilage;Collaborations;Communities;community engagement;Complement;cost;Data Analyses;Data Analytics;Disease;disease model;Disease Outcome;Engineering;Environment;Equipment;experience;Experimental Designs;experimental study;Financial Support;Fostering;Funding;Genetic;Genomics;Goals;Growth;Health;Histology;Human;Human Development;improved;in vivo;Inbred Strain;Individual;Injury;innovation;Knowledge;Laboratories;Leadership;Ligaments;Measurement;Measures;Mechanics;Methodology;Michigan;Molecular;multimodal data;multimodality;Muscle;Muscle function;Musculoskeletal;Musculoskeletal Development;Musculoskeletal Diseases;Musculoskeletal System;neuromuscular function;new technology;novel;Organ;Organism;Outcome;Pathogenesis;Pathology;Pathway interactions;Phenotype;Physiology;pre-clinical assessment;pre-clinical research;preclinical study;Proliferating;Proteomics;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Resolution;Resources;response to injury;Rodent;Scientist;Services;sex;soft tissue;Specificity;Standardization;Structure;Surgical Models;targeted treatment;Techniques;Technology;Tendon structure;Testing;therapeutic evaluation;therapeutic target;Tissue Banks;Tissue imaging;tissue regeneration;Tissues;tool;Training;Universities

PROJECT_TITLE: Function Core - Core C


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Precision Medicine;Skin Cancer

ORG_CITY: NEW HAVEN

ORG_DEPT: PATHOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative For many patients with melanoma, treatment with targeted therapies initially shows great promise only for the disease to return, often without any new mutations that explain why the treatment stopped working. This proposal aims to define non-genetic mechanisms that explain how cancers like melanoma become resistant to therapy. By understanding these mechanisms we can unlock new therapeutic strategies to overcome treatment failure.

PI_NAMEs: GARG, SALIL  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Academic Medical Centers;accurate diagnostics;Adjuvant Therapy;Automobile Driving;Bar Codes;Biological Models;biological systems;Biology;Bromodomain;cancer therapy;career;CDKN2C gene;Cell Count;Cell Line;Cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Data;Development Plans;Diagnosis;Diagnostic;Disease;DNA Sequence Alteration;Enhancers;Epidermal Growth Factor Receptor;Epigenetic Process;Event;experience;Exposure to;FGFRL1 gene;Gene Expression;Gene Expression Regulation;General Hospitals;Genes;Genetic;genome-wide;Genomics;Goals;Heterogeneity;human disease;inhibitor;insight;interest;Laboratories;Libraries;Malignant Neoplasms;MAP Kinase Gene;Massachusetts;Melanoma;Melanoma Cell;Melanoma patient;Mentors;Molecular;Mutation;non-genetic;novel;novel therapeutic intervention;novel therapeutics;Oncologist;Pathologist;Pathology;Pathway interactions;Patients;personalized medicine;pharmacologic;Play;Population;Positioning Attribute;precision medicine;prevent;Principal Investigator;Process;programs;Recurrent disease;Reporting;Research;Research Proposals;Resistance;resistance gene;Role;Sampling;Secondary to;single-cell RNA sequencing;success;System;Systems Biology;targeted treatment;Techniques;Technology;tenure track;Testing;therapeutic target;therapy resistant;Time;Training;Treatment Failure;tumor;Tumor Escape;Variant;Work

PROJECT_TITLE: Mechanisms of non-genetic variation in melanoma


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Regenerative Medicine;Wound Healing and Care

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Multidrug-resistant (MDR) bacteria are among the most immediate threats to human health, causing life- threatening illnesses and, increasingly, infections for which currently available antibiotics are simply ineffective. To help counter this danger, we propose to establish chemokine-derived peptides as novel therapeutics that exert direct bactericidal activity against MDR pathogens, as well as host-targeted bioregulatory effects beneficial to combating wound/surgical-site infections and promoting healing. Our investigations will demonstrate an innovative new paradigm for addressing the mounting burden of MDR pathogens and curtailing the continued emergence/spread of antimicrobial resistance in clinical settings.

PI_NAMEs: HUGHES, MOLLY A (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Address;Adoption;Affect;Amino Acids;Animal Experimentation;Anti-Infective Agents;Antibiotics;antimicrobial;Antimicrobial Resistance;Area;arms race;Bacteria;bacterial resistance;bactericide;Biological;Biological Process;Biology;cancer therapy;carbapenem-resistant Enterobacteriaceae;Cell Physiology;Cells;Chemistry;chemokine;Clinical;Clinical Management;clinically significant;Collection;combat;combat wound;combinatorial;Communicable Diseases;cost;CXCL10 gene;cytotoxicity;Data;Dermal;Development;Disease Progression;dosage;Dose;drug discovery;efficacy evaluation;Equilibrium;Etiology;Exhibits;Fortification;Foundations;Gram-Positive Bacteria;healing;Health;healthcare-associated infections;Host Defense;Human;human pathogen;Immune;immune clearance;Immunotherapy;immunotoxicity;In Vitro;in vivo;in vivo regeneration;Individual;Infection;Injury;innovation;insight;Intention;Invaded;Investigation;Klebsiella pneumoniae;Laboratories;Lead;lead series;Life;man;Measures;Mediating;methicillin resistant Staphylococcus aureus;Methodology;Microbe;microorganism;Modeling;mortality;mouse model;Multi-Drug Resistance;multi-drug resistant pathogen;Multiple Bacterial Drug Resistance;Mus;Natural regeneration;next generation;novel therapeutics;Outcome;pathogen;pathogenic bacteria;Pattern;Peptide Hydrolases;Peptides;Periodicity;Phenotype;Physiological;Pneumonia;pre-clinical;pressure;Process;Productivity;receptor;Recovery;regenerative;Regenerative Medicine;Research;Research Activity;Resistance;Resources;Shapes;Surgical Wound Infection;System;Technology;Testing;Therapeutic;therapeutic development;therapeutic target;tissue repair;Treatment Efficacy;usability;wound;wound bed;wound healing;Wound Infection;wound treatment

PROJECT_TITLE: A unique strategy for reshaping the antibiotics model: chemokine-inspired therapeutics for targeting the host and pathogen to counter infections caused by multidrug-resistant bacteria

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Hematology;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Rare Diseases;Sickle Cell Disease

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: PROJECT NARRATIVE Sickle cell disease (SCD) is characterized by involvement of multiple end organs, resulting in multiple complications including chronic kidney disease (CKD). CKD as well as rapid decline of kidney function are common in SCD, and are associated with increased risk of death. We propose studies to identify individuals at high risk for progression of CKD using machine learning models, and to evaluate the kidney-protective effects of voxelotor, a novel inhibitor of sickle hemoglobin polymerization, in individuals at risk for rapid decline in kidney function.

PI_NAMEs: ATAGA, KENNETH I (contact);SARAF, SANTOSH

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Address;Adult;Affect;Affinity;African American population;Albuminuria;Angiotensin Receptor;Angiotensin-Converting Enzyme Inhibitors;APOL1 gene;Biological Availability;Chronic Kidney Failure;Early identification;functional decline;Functional disorder;General Population;Glomerular Filtration Rate;Hemoglobin;hemoglobin polymer;Hemolysis;Hemolytic Anemia;High Prevalence;high risk;hydroxyurea;Immune response;improved;Individual;Inflammatory Response;Injury;Injury to Kidney;Ischemic Stroke;Kidney;Kidney Diseases;Life Expectancy;machine learning model;machine learning prediction;Measures;Mediating;modifiable risk;Morbidity - disease rate;mortality;mortality risk;Multicenter Studies;Nitric Oxide;novel;Organ;Oxidative Stress;Oxygen;Pathogenesis;Pathway interactions;patient population;Patients;Pharmaceutical Preparations;Pharmacotherapy;Prevalence;prevent;progression risk;prospective;protective effect;Pulmonary Hypertension;randomized, controlled study;renal damage;Renal function;Reporting;Risk;Risk Factors;Severities;Sickle Cell;Sickle Cell Anemia;Sickle Hemoglobin;sickling inhibitor;small molecule;standard of care;targeted treatment;Testing;Urine;Variant;Vascular Diseases

PROJECT_TITLE: Predicting Progression of Chronic Kidney Disease in Sickle Cell Anemia Using Machine Learning Models (PREMIER)

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Nanotechnology;Natural Products;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: CHARLOTTE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF NORTH CAROLINA CHARLOTTE

ORG_STATE: NC

PHR: Narrative Pancreatic ductal adenocarcinoma (PDAC) is the fourth-leading cause of cancer-related mortality in the United States having the worst prognosis with 5-year survival rate of 10%. In this project, we pursue the development of a sequential therapy using targeted stimuli-responsive drug delivery nanocarriers for the treatment of advanced PDAC. The proposed research is relevant to public health because it will develop reliable technologies for the effective treatment of advanced PDAC.

PI_NAMEs: VIVERO-ESCOTO, JUAN LUIS (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Abraxane;Antibodies;Antigen Targeting;Antineoplastic Agents;Behavior;bench-to-bedside translation;Biodistribution;Biological;Biological Availability;Biological Markers;Cancer Etiology;Cessation of life;Chemoresistance;chemotherapy;Circulation;Cisplatin;Clinic;Clinical;clinical effect;clinically relevant;combinatorial;Combined Modality Therapy;cyclopamine;Data;design;Desmoplastic;Development;Disease;DNA Repair;Drug Delivery Systems;Drug Kinetics;effective therapy;Evaluation;Exocrine pancreas;Failure;gemcitabine;Goals;Half-Life;Heterogeneity;Immunocompetent;improved;inhibitor;Investigation;Malignant - descriptor;Methods;Modeling;mortality;mouse model;Mucin 1 protein;Mucins;Mus;Mutation;nanocarrier;nanoparticle;nanoparticle delivery;nanotechnology platform;Neoplasm Metastasis;novel;Organ;Outcome;Outcomes Research;overexpression;Paclitaxel;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;patient derived xenograft model;Patients;Performance;Pharmaceutical Preparations;Prognosis;Proteins;Public Health;Regimen;Research;Resistance;resistance mechanism;Role;Safety;safety outcomes;SHH gene;Signal Pathway;Silicon Dioxide;Site;Stimulus;Survival Rate;System;targeted treatment;Technology;Therapeutic;therapeutic effectiveness;therapy outcome;therapy resistant;Toxic effect;Transgenic Organisms;Translations;Treatment Efficacy;tumor;tumor heterogeneity;tumor microenvironment;tumor progression;United States

PROJECT_TITLE: Stimuli-responsive mucin1-specific nanoparticles for efficacious combinatorial chemotherapy of pancreatic ductal adenocarcinoma


NIH_SPENDING_CATS: Arthritis;Bioengineering;Biomedical Imaging;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: PARKER, STEPHEN CJ (contact)

PROJECT_TERMS: Acceleration;Adipose tissue;Algorithm Design;Amplifiers;analytical method;analytical tool;Artificial Intelligence;Atlases;Big Data;Black Box;bone age;Cartilage;Clinical;Clinical Data;Communities;Complex;Computational Technique;Computer Assisted;Computer software;Computing Methodologies;Data;Data Analyses;Data Analytics;Data Collection;data management;data modalities;Data Storage and Retrieval;Decision Support Systems;deep learning;Defect;Degenerative polyarthritis;denoising;design;Detection;Development;Diagnosis;Disease;diverse data;Environment;epigenome;Experimental Designs;feature extraction;Fracture;Functional Imaging;Future;Generations;Genome;Health;Human;Image;Image Analysis;Image Enhancement;image processing;Imaging Device;imaging Segmentation;Imaging technology;improved;Individual;innovation;instrument;Investments;Knowledge;Laboratories;Leadership;Machine Learning;machine learning method;machine learning model;Methodology;Methods;Michigan;Mission;Modality;model organism;Modeling;Molecular;multidisciplinary;Muscle;Musculoskeletal;Musculoskeletal Diseases;nano;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;novel;novel strategies;Outcome Study;Output;Patient-Focused Outcomes;Performance;phenotypic data;pre-clinical;Protocols documentation;Quality Control;Raman Spectrum Analysis;Randomized;Recommendation;Research;Research Design;Research Personnel;Resources;Science;sensor;Services;soft tissue;Source;Standardization;statistical and machine learning;structural imaging;System;Techniques;Technology;Texture;Tissues;tool;Training;trait;transcriptome;Universities;Validation;webinar;Work;X-Ray Computed Tomography

PROJECT_TITLE: Integrative Data Analytics Core - Core D


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Heart Disease;Machine Learning and Artificial Intelligence;Pediatric;Pediatric Cardiomyopathy;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: NARRATIVE Hypertrophic cardiomyopathy (HCM) is heart muscle disease that can cause disabling symptoms, dangerous heart rhythm disturbances, and premature death. Mutations in the genes that encode the sarcomere, the molecular motor of the heart, are the most frequent cause of HCM, however, there is tremendous variation in disease experience from one patient to the next. This project aims to identify genetic and non-genetic factors that influence disease severity and clinical outcomes in HCM.

PI_NAMEs: HO, CAROLYN Y (contact)

PROGRAM_OFFICER_NAME: BURNS, KRISTIN

PROJECT_TERMS: 3-Dimensional;Accounting;Address;Adverse event;adverse outcome;Affect;Arrhythmia;Atlases;Atrial Fibrillation;automated analysis;automated segmentation;Automobile Driving;Basic Science;Cardiac;cardiac magnetic resonance imaging;cardiac muscle disease;Cardiomyopathies;Cardiovascular Diseases;case control;Cessation of life;Classification;Clinical;Clinical Course of Disease;clinical heterogeneity;Clinical Management;clinical predictors;clinical risk;Clinical Sciences;cohort;Complex;Computer Vision Systems;Dangerousness;Data;Data Set;Diagnosis;diagnostic accuracy;digital;digital data;disabling symptom;Disease;disease heterogeneity;Disease Resistance;disease-causing mutation;disorder risk;DNA;EFRAC;experience;Family;family management;Fibrosis;follow-up;Genes;Genetic;genetic analysis;genetic makeup;Genetic Predisposition to Disease;genetic testing;genetic variant;Genetic Variation;genome wide association study;Genomics;Genotype;Geometry;Goals;Heart;heart dimension/size;Heart Diseases;Heart failure;heart function;heart imaging;heart rhythm;Heterogeneity;high dimensionality;Human;Hypertrophic Cardiomyopathy;Image;improved;Individual;insight;Left Ventricular Hypertrophy;Longevity;Machine Learning;machine learning algorithm;Magnetic Resonance;Modeling;Molecular;Molecular Motors;Morphology;Muscle Cells;Mutation;Natural History;new therapeutic target;non-genetic;novel;novel marker;Outcome;outcome prediction;Patient Care;patient population;Patient-Focused Outcomes;Patients;Penetrance;Performance;personalized diagnostics;Persons;Phenotype;Physicians;polygenic risk score;predictive modeling;Predisposition;premature;preservation;Prevalence;Registries;resilience;Resolution;risk prediction;risk prediction model;risk stratification;Sarcomeres;secondary analysis;segmentation algorithm;Severity of illness;SNP array;Specificity;Standardization;Statistical Data Interpretation;Structure;success;sudden cardiac death;Symptom Burden;Symptoms;Techniques;therapeutic target;Thick;trait;Variant

PROJECT_TITLE: Hypertrophic Cardiomyopathy: Understanding the Heterogeneity of Disease Expression and Outcomes

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative With the rise in the impact of cardiovascular disease on US and world health, it is critical to train the next generation of investigators in translational vascular research. Stanford University has world-class faculty, the necessary resources, and the collaborative milieu to address the major public health problem of cardiovascular disease. This multidisciplinary T32 training program in Translational Vascular Research is designed to train postdoctoral fellows in clinical, translational, and basic vascular medicine and research and medical ethics, and to foster their development into investigators dedicated to identifying innovative solutions and capable of translating basic research into clinical success to combat vascular diseases.

PI_NAMEs: LEEPER, NICHOLAS JAMES;TSAO, PHILIP S (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TITLE: T32 Training Program in Mechanisms and Innovation in Vascular Disease

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


NIH_SPENDING_CATS: Autoimmune Disease;Cardiovascular;Heart Disease;Prevention;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE Bacterial ligand-induced murine vasculitis, coronary arteritis and myocarditis is highly dependent of NLRP3 inflammasome activation and bioactive IL-1β release. Here, we will characterize the role of neutrophils and eosinophils infiltrating the inflamed tissues and investigate how the modulation of NLRP3 and PAD4 activity could prevent the vascular innate immune responses leading to vascular inflammation and injury.

PI_NAMEs: ARDITI, MOSHE  (contact);NOVAL RIVAS, MAGALI

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: abdominal aorta;Abdominal Aortic Aneurysm;Acute;Affect;Alternative Therapies;anakinra;Aneurysm;animal data;Animal Model;antagonist;Aortitis;Arteritis;Blood Vessels;Cardiovascular system;Cell Wall;Cells;Child;Childhood;Chronic;Clinical Trials;Coronary;Coronary Aneurysm;coronary arteritis;Coronary artery;cytokine;Cytokine Signaling;Data;Development;Disease;disease model;eosinophil;Etiology;experimental study;extracellular;Family;Fever;Gene Expression;Genetic;Heart Diseases;Histologic;Human;IL1R1 gene;Immune;Immunoglobulin G;Immunologics;In Vitro;in vivo;Incidence;infection risk;Infiltration;Inflammasome;Inflammation;Inflammation Mediators;Inflammatory;Innate Immune Response;Interleukin-1;Interleukin-1 beta;Intervention;Intravenous Immunoglobulins;Lactobacillus casei;Lesion;Ligands;Maps;member;Modeling;Monoclonal Antibodies;mouse model;Mucocutaneous Lymph Node Syndrome;Mus;Myocarditis;neutrophil;Neutrophil Infiltration;new therapeutic target;novel strategies;novel therapeutics;Pathogenesis;Pathogenicity;Pathologic;Pathology;Patients;prevent;Prevention;Prevention approach;Production;Proteins;receptor;Research Priority;Resistance;Risk;Role;Serine Protease;Severities;Signal Transduction;Testing;Tissue Sample;Tissues;Transcript;vascular inflammation;vascular injury;Vasculitis

PROJECT_TITLE: Role of neutrophils and eosinophils in bacterial ligand-induced vasculitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-D(02)M]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Finding an effective treatment for dry eye is challenging. Topical N-94/C-6 ('Lacripep'), a natural fragment of the tear protein lacritin (deficient in dry eye) addressed sign and symptom within two weeks in the recent phase II trial NCT03226444. Here we work out more fully the mechanisms of action by characterizing the receptor complex, including proximal and distal mediators, and develop a model.

PI_NAMEs: LAURIE, GORDON WILLIAM (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Acceleration;Address;Afferent Neurons;Autophagocytosis;Binding;Binding Sites;Biochemical;C-terminal;Calcineurin;Calcium;California;Cell surface;Cells;Cellular Stress;Cessation of life;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;Complementary DNA;Complex;Controlled Study;Cornea;corneal epithelium;CRISPR/Cas technology;Cryoelectron Microscopy;Cytoplasm;Cytoplasmic Tail;data integration;design;Development;Distal;Dose;Dry Eye Syndromes;effective therapy;Elements;epithelial repair;Epithelium;evaporation;experimental study;Extracellular Domain;eye dryness;FOXO1A gene;FOXO3A gene;FRAP1 gene;G-Protein-Coupled Receptors;Gene Targeting;Genes;genome-wide;Goals;GTP-Binding Proteins;Health;Homeostasis;Human;improved;in vitro Model;induced pluripotent stem cell;Inflammation;Interferon Type II;Ion Channel;knock-down;Label;lacrimal;Ligation;Lipids;lysophosphatidic acid;Lysophosphatidic Acid Receptors;Masks;Mass Spectrum Analysis;Mediator;Mitochondria;Modeling;mouse model;Mus;mutant;Mutation;nerve supply;neural;nuclear factors of activated T-cells;ocular surface;Oxidative Phosphorylation;Peroxidases;Pertussis Toxin;Phase II Clinical Trials;phase II trial;Placebo Control;Placebos;Proteoglycan;Proteome;Randomized;receptor;Receptor Signaling;Regulation;Replacement Therapy;restoration;Risk Factors;Role;San Francisco;Sensory;Signal Pathway;Signal Transduction;Signs and Symptoms;Sjogren's Syndrome;small hairpin RNA;syndecan;System;tear proteins;Therapeutic;TNF gene;Universities;Virginia;Work

PROJECT_TITLE: Lacritin Regulation of Homeostasis and Ocular Surface Health

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: EXTON

ORG_NAME: PRAEVENTIX, LLC

PHR: Substance use disorder (SUD) is a major, unmet medical condition with a global impact. According to the 2018 National Survey on Drug Use and Health, ~32 million people over the age of 12 in the U.S. had reported using an illicit drug in the past 30 days, and >8.1 million people were addicted to illicit drugs. Cocaine is one of the most commonly abused illicit drugs. Despite the clear and compelling need, there are no FDA approved medications for the treatment of cocaine use disorder (CUD). We have identified a preliminary series of novel, drug-like 5-HT7 antagonists that include compounds, PRA073 and PRA078, which produce a positive impact in the cocaine reinstatement rat model of addiction in our preliminary studies. In this program, we will continue our efforts focused on identifying novel, selective 5-HT7 antagonists suitable for evaluation in in vivo efficacy models of CUD and eventual pre-clinical evaluation.

PI_NAMEs: BLASS, BENJAMIN ;CANNEY, DANIEL J;PIPPIN, DOUGLAS ANTHONY (contact);WALKER, ELLEN ANN

PROGRAM_OFFICER_NAME: KARUPPAGOUNDER, SARAVANAN SHANMUGAM

PROJECT_TERMS: ABCB1 gene;Acceleration;Accident and Emergency department;Acute;addiction;Affect;Age;analog;antagonist;Attention;Behavioral;Binding;Binding Proteins;Biological Assay;Biological Availability;Brain;Brain region;Chronic;Cocaine;cocaine exposure;cocaine seeking;cocaine self-administration;cocaine use;Cocaine use disorder;Cognitive;Cues;Decision Making;Dopamine;dopamine system;dopaminergic neuron;Dose;Drug abuse;Drug Kinetics;drug of abuse;Drug usage;Effectiveness;effectiveness evaluation;effectiveness testing;efficacy evaluation;efficacy study;Electrophysiology (science);Emotional;enantiomer;Euphoria;Evaluation;Executive Dysfunction;executive function;Exhibits;experimental study;Extinction;FDA approved;Female;flexibility;Generations;Health;Hepatocyte;Hospitals;Human;illicit drug use;Illicit Drugs;improved;In Vitro;in vivo;Injections;Lactams;Lactones;Lead;learning extinction;Link;Literature;Maintenance;male;Medical;Metabolic;Microsomes;Modeling;Modification;Molecular;neural circuit;Neurons;novel;novel strategies;Oral;Orthologous Gene;patch clamp;Patients;Permeability;Persons;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Phase;phase 2 study;Plasma;Plasma Proteins;pre-clinical;preclinical evaluation;Process;programs;Protocols documentation;radioligand;Rattus;receptor;Reinforcement Schedule;Relapse;Reporting;Research;response;reuptake;Reversal Learning;Rewards;Role;Running;safety assessment;screening;Series;Serotonin;serotonin 7 receptor;serotonin receptor;Services;sex;Signal Transduction;Solubility;stem;Stress;Substance Use Disorder;Surveys;System;Testing;Therapeutic;Time;Treatment outcome;Yohimbine

PROJECT_TITLE: In Vivo Characterization of 5-HT7 Modulators in Rat Models of Cocaine Use Disorder


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;HIV/AIDS

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PI_NAMEs: ADEPOJU, OMOLOLA E (contact)

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurosciences;Social Determinants of Health

ORG_CITY: NORMAN

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA

ORG_STATE: OK

PHR: Contact PD/PI: Everman, Elizabeth PROJECT NARRATIVE Mapping quantitative trait variation to specific genes has proved critical for our understanding of the genetic basis of disease in humans, and the same approaches can be used to identify genes and networks that are responsible for variable resistance to metal poisoning in natural populations. Here I will combine powerful, highly replicated genetic mapping with multiple behavioral and physiological assays and whole genome and RNA sequencing to characterize the genetic basis of resistance to copper poisoning. By exploiting an elite model genetic system, this work will provide novel insight into genetic variants that influence susceptibility to metal poisoning in humans.

PI_NAMEs: EVERMAN, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: acute toxicity;Adult;Alleles;Bar Codes;Behavior;behavior influence;Behavioral;behavioral response;bioaccumulation;Biological Assay;Biological Models;Cadmium;Candidate Disease Gene;Cessation of life;Chromosome Mapping;Communities;Complex;coping;Copper;copper poisoning;Coupled;Data;Decision Making;Desire for food;Detection;Development;disability;Disease;DNA Resequencing;Drosophila genus;Drosophila melanogaster;endophenotype;environmental stressor;Evolution;experimental study;Exposure to;fly;gene environment interaction;Gene Expression;gene expression variation;Gene Frequency;Generations;Genes;Genetic;genetic architecture;Genetic Models;genetic risk factor;genetic variant;Genetic Variation;genome sequencing;Genomics;Health;Heavy Metals;Human;human disease;Infrastructure;innovation;insight;interest;Investigation;large datasets;Lead;Learning;Learning Disabilities;Life;life history;Link;low socioeconomic status;Manganese;Maps;Measures;Memory;Metal exposure;metal metabolism;metal poisoning;Metals;Modeling;Morbidity - disease rate;Natural Resistance;neglect;Nervous System Disorder;Nervous System Physiology;Neurologic;novel;Organism;Pathology;Pathway interactions;Phase;Phenotype;Physiological;Physiology;pollutant;Pollution;Population;Poverty;Predisposition;preference;pressure;Process;Quantitative Trait Loci;racial disparity;Recording of previous events;Research;Resistance;Resources;response;Risk;RNA;Sensory;Stress;stressor;Syndrome;System;Testing;Time;tool;Toxic effect;trait;transcriptome sequencing;Validation;Variant;whole genome;Whole Organism;Work;Zinc

PROJECT_TITLE: Linking genomic, physiological, and behavioral responses using a Drosophila model of heavy metal stress

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Cannabinoid Research;Cardiovascular;Endocannabinoid System Research;Heart Disease;Microbiome;Substance Misuse

ORG_CITY: NEW ORLEANS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: Project narrative: Excessive binge alcohol drinking negatively affects cardiovascular function lasting for several hours. Acute alcohol intoxication is associated with elevated levels of the cardiac endocannabinoid anandamide that exerts important cardiovascular effects and induces redistribution of circulation via activating CB1 receptor signaling. In this proposal we aimed to investigate the role of gut-heart axis in binge alcohol drinking-associated peripheral CB1 receptor activation and subsequent cardiovascular dysfunction by characterizing the cellular source of endocannabinoids and the triggers of their production in the cardiovascular system.

PI_NAMEs: PALOCZI, JANOS  (contact)

PROGRAM_OFFICER_NAME: LIN, LI

PROJECT_TERMS: Achievement;Acute;Acute myocardial infarction;Advisory Committees;Affect;Agreement;Alcohol consumption;alcohol exposure;alcohol measurement;alcohol research;Alcoholic Intoxication;Alcohols;analog;anandamide;antagonist;Arteries;Atrial Fibrillation;Attenuated;binge drinking;Blood Vessels;Cardiac;Cardiac Myocytes;cardiovascular effects;Cardiovascular Physiology;Cardiovascular system;cell type;Circulation;CNR1 gene;Consumption;cytotoxic;Development;endocannabinoid signaling;Endocannabinoids;endogenous cannabinoid system;Endothelium;Endotoxemia;Endotoxins;Event;experimental study;Extramural Activities;Fibroblasts;Functional disorder;Goals;gut microbiome;gut microbiota;Heart;Heavy Drinking;Hour;Impairment;improved;In Vitro;in vivo;Individual;Injury;Institution;interest;intestinal barrier;Knockout Mice;Lead;Left Ventricular Function;Life;Link;member;Mentors;mouse model;Myocardial;Myocardium;Names;National Institute on Alcohol Abuse and Alcoholism;novel;Pattern;Peripheral;Plants;Play;Process;Production;Publications;receptor;Receptor Activation;receptor expression;Receptor Signaling;Research Personnel;response;Role;Science;Scientist;Signal Transduction;Source;Time;Training;United States;Vascular Diseases;Vascular Smooth Muscle;Vasodilation;Veins

PROJECT_TITLE: The role of gut-heart axis in acute alcohol intoxication-induced adverse cardiovascular events


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Primary Health Care

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE The vast majority of people with depression worldwide receive no treatment. To address this need, healthcare workers in over 90 countries have been trained in the WHO’s depression treatment guidelines (mhGAP), but often receive no ongoing support to implement the guidelines in their practice. The proposed project develops and tests a blended in-person/mobile phone-based support strategy to help primary healthcare nurses in Zimbabwe to diagnose and treat depression.

PI_NAMEs: JACK, HELEN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: acceptability and feasibility;Address;Advisory Committees;Area;arm;behavioral health;Care given by nurses;Cellular Phone;Child Care;Clinic;Clinical;clinical decision support;clinical practice;Clinical Practice Guideline;Clinical Skills;clinical training;Clinical Trials;Cluster Analysis;Cluster randomized trial;cluster trial;Collaborations;college;Country;Data;Data Collection;Dedications;Depression screen;design;Development;Diagnosis;Education;effectiveness/implementation trial;evidence base;Evidence based treatment;experience;Focus Groups;Friendships;Funding;Future;Guidelines;Health;health care delivery;Health Personnel;Healthcare;human centered design;implementation barriers;implementation evaluation;implementation outcomes;implementation science;implementation strategy;improved;instructor;Internal Medicine;Interview;K-Series Research Career Programs;Literature;London;low and middle-income countries;Measures;Mental Depression;Mental disorders;Mental Health;mental health organization;Mental Health Services;Mentors;Mentorship;Methods;Nurses;Outcome;Patients;Persons;Pharmaceutical Preparations;Phase;pilot test;pilot trial;Population;Primary Care;primary care clinic;primary care practice;Primary Health Care;Primary Nursing Care;Probability;programs;Provider;Psychiatric Nursing;Psychiatrist;Psychological reinforcement;Psychotherapy;Publications;Randomized;Randomized, Controlled Trials;Research;Research Personnel;Research Project Grants;Resource-limited setting;Sampling;scale up;screening;Series;Supervision;Surveys;Testing;Time;Training;Training Programs;Training Support;Treatment Cost;treatment guidelines;trial design;United States National Institutes of Health;Universities;uptake;Visit;Washington;Work;World Health Organization;X Inactivation;Zimbabwe

PROJECT_TITLE: Practice facilitation and supervision to strengthen depression treatment in primary care in Zimbabwe

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PI_NAMEs: ALMEIDA-PORADA, GRACA DUARTE;CROWLEY, STEVEN D;HOGAN, SUSAN LYNN (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Admission activity;Adoption;Agriculture;Basic Science;Biomedical Research;Biotechnology;career;Clinical;Clinical and Translational Science Awards;Clinical Research;Clinical Sciences;Communities;Development;Disparity;Emerging Technologies;Environment;experience;Faculty;Fostering;Future;Hematology;high school;Historically Black Colleges and Universities;improved;innovation;Institution;Kidney;Leadership;Learning;Longevity;medical specialties;Mentors;Mission;multidisciplinary;National Research Service Awards;next generation;North Carolina;outreach;patient population;Postdoctoral Fellow;pre-doctoral;Process;Program Evaluation;programs;Public Health;Qualifying;recruit;Research;Research Personnel;Research Training;scale up;Science;skill acquisition;skills;social;support network;synergism;Technology;Time;TNFSF15 gene;tool;Training;Training and Infrastructure;Training Programs;Translational Research;Universities;urologic

PROJECT_TITLE: TRIO NRSA Training Core


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Chronic Pain;Comparative Effectiveness Research;Neurosciences;Pain Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: ICERCH as the Recruitment Resource Center will work collaboratively with each ERN study team and the other HEAL ERN Resource Centers and continue to develop and monitor comprehensive strategies to address barriers to recruitment and retention in the five funded HEAL pain studies and two additional studies, demonstrate their effectiveness in recruiting diverse participants and broadly disseminate evidence on the most effective approaches to recruitment and retention of people who have pain. The HEAL Pain Management Effectiveness Research Network (ERN) is a key component of the initiative and to be successful, these ERN trials will need to efficiently recruit participants and minimize dropouts. To ensure HEAL Pain ERN studies accrue and retain the number and diversity of participants required to assess primary and secondary outcomes, we propose a Recruitment Resource Center to support the development of a robust recruitment infrastructure, complete with the tools, resources, and innovative strategies needed to proactively address recruitment barriers and rapidly identify and mitigate emerging roadblocks across sites.

PI_NAMEs: HARRIS, PAUL A. (contact);WILKINS, CONSUELO HOPKINS

PROGRAM_OFFICER_NAME: VALLEJO, YOLANDA F

PROJECT_TERMS: Academic Medical Centers;Acute;Address;Behavioral;chronic pain;Clinical Trials Network;Collaborations;Consent;Development;Dropout;effective intervention;Effectiveness;effectiveness research;electronic consent;Enrollment;Ensure;functional improvement;Funding;Incentives;Infrastructure;innovation;Monitor;novel;Pain;Pain management;pain reduction;Participant;participant retention;Patient Recruitments;Patients;Persons;primary outcome;recruit;Research Personnel;Resources;retention rate;screening;secondary outcome;Services;Site;social;study population;tool;Translational Research;Work

PROJECT_TITLE: ICERCH-Supporting the HEAL Pain ERN


NIH_SPENDING_CATS: Aging;Arthritis;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Nutrition;Obesity;Osteoarthritis;Pain Research;Physical Activity;Prevention;Women's Health Research

ORG_CITY: WINSTON-SALEM

ORG_DEPT: MISCELLANEOUS

ORG_NAME: WAKE FOREST UNIVERSITY

PHR: PROJECT NARRATIVE The importance of OA disease prevention is evident because we presently have no effective disease- modifying interventions, there are substantial safety concerns associated with many pain medications, and there is no cure. This Phase III randomized clinical trial will test a critically needed primary prevention intervention on females at risk for the development of structural knee OA by implementing a program of dietary weight loss, exercise, and weight-loss maintenance designed for long-term sustainability to maximize health benefits at a reasonable cost.

PI_NAMEs: MESSIER, STEPHEN P (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Address;Adult;Adult women;Affect;aged;Analgesics;attentional control;Australia;Body mass index;Body Weight decreased;Boston;Cartilage;Clinical;cohort;Communities;comorbidity;Computer Simulation;Control Groups;cost;cost effective;cost effectiveness;County;Data;Degenerative polyarthritis;design;Development;Diagnosis;dietary;Dietary Intervention;disability;Disease;Disease Pathway;disorder prevention;effective therapy;Effectiveness of Interventions;Eligibility Determination;Exercise;Female;Health Benefit;health related quality of life;high risk;High Risk Woman;Hospitals;improved;Individual;Inflammatory;innovation;Inpatients;Interleukin-6;Intervention;intervention effect;joint inflammation;joint loading;Joints;Knee;Knee Injuries;Knee joint;Knee Osteoarthritis;knee pain;Magnetic Resonance Imaging;Maintenance;male;Measures;Mental Health;models and simulation;multimodality;Obesity;Outcome;Overweight;Pain;Participant;Phase;physical conditioning;Plasma;Play;Populations at Risk;prevent;Prevention;Prevention strategy;preventive intervention;Preventive therapy;Primary Prevention;programs;radiological imaging;randomized, clinical trials;Risk;Role;Safety;secondary outcome;Self Efficacy;SF-36;Site;Testing;therapy design;Treatment Efficacy;Walking;Weight-Bearing state

PROJECT_TITLE: The Osteoarthritis Prevention Study (TOPS)


NIH_SPENDING_CATS: Atherosclerosis;Behavioral and Social Science;Burden of Illness;Cardiovascular;Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Heart Disease - Coronary Heart Disease;Pain Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Most US employees have health insurance with greater than $1,000 deductibles, yet little research has studied how high out-of-pocket costs affect patients experiencing acute cardiovascular emergencies such as heart attacks. The proposed research will advance our understanding of high-deductible health plans’ impact on outcomes from heart attacks, unnecessary hospitalizations for chest pain, and patients’ perspectives on how high out-of-pocket costs influence their care decisions and perceived care quality. Results from these studies will provide important implications for future insurance regulations to minimize unintended harm, reduce the financial burden of care, and align clinical decisions with patients’ value perspectives.

PI_NAMEs: CHOU, SHIH-CHUAN  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Accident and Emergency department;Active Learning;Acute;acute care;acute coronary syndrome;Acute myocardial infarction;Adherence;Admission activity;Affect;Award;Behavior;Cardiac;Cardiovascular Diseases;cardiovascular emergency;Cardiovascular system;care burden;care outcomes;care seeking;career;career development;Caring;Chest Pain;Chronic Disease;Clinical;Complement;cost;Cost Sharing;Cost-Sharing Insurance;curriculum development;Data;Databases;Deductibles;design;Disease Management;Disease Outcome;Elements;Emergency Care;Emergency Department evaluation;Emergency Department patient;Emergency department visit;Emergency Medicine;Emergency Situation;Employee;empowerment;Enrollment;Ensure;Evaluation;experience;Face;Financial Hardship;Funding;Future;Goals;Grant;Growth;Health;Health Care Costs;health care disparity;Health Insurance;health plan;health savings account;Healthcare;Heart Diseases;High Prevalence;hospital readmission;Hospitalization;Image;Incentives;Inpatients;insight;Insurance;Insurance Benefits;Insurance Carriers;insurance claims;interest;Interview;Ischemia;Low income;Low Income Population;Measures;member;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Myocardial Infarction;Natural experiment;Observational Study;Outcome;Patient-Focused Outcomes;Patients;Perception;Physicians;Policies;policy recommendation;preservation;Price;Qualitative Research;Quality of Care;Quasi-experiment;Randomized;Regulation;Research;research and development;Research Design;Research Methodology;Research Personnel;Role;Scientist;Screening for cancer;Severities;shared decision making;Surveys;Survival Analysis;Testing;Training;Uninsured Medical Expense;Variant;Visit;Work;Writing

PROJECT_TITLE: Impact of Health Deductible Health Plans on the Evaluation, Treatment, and Outcomes for Acute Coronary Syndrome

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Genetics;Immunotherapy;Liver Cancer;Liver Disease;Prevention;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative The incidence of hepatocellular carcinoma (HCC) has been increasing in Western countries as a consequence of obesity. Available immunotherapies are largely unsuccessful for the treatment of HCC. We have shown that miR-15a/16 fully prevented HCC in three HCC mouse models by recovering anti-tumor immunity. We expect that this study will provide novel insight into the immunosuppression mechanism in HCC and facilitate the design of KCs as a new therapeutic target and miR-15a/16 as a rational immunotherapy against HCC.

PI_NAMEs: SONG, GUISHENG  (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Attenuated;Automobile Driving;beta-Chemokines;Blood;c-myc Genes;cell motility;Cell Separation;Cell Therapy;Cells;chemokine;chemokine receptor;Country;CRISPR/Cas technology;cytokine;Cytotoxic T-Lymphocytes;Data;design;Development;Diethylnitrosamine;Etiology;Experimental Designs;Genetic Transcription;Goals;Grant;Growth;Hepatic;Hepatocyte;Homologous Gene;Immune;Immunosuppression;Immunotherapy;Impairment;In Vitro;in vivo Model;Incidence;ineffective therapies;Injections;insight;knock-down;Kupffer Cells;Liver;liver cancer model;Liver neoplasms;Malignant Neoplasms;Mediating;Messenger RNA;MicroRNAs;migration;mortality;mouse model;Mus;new therapeutic target;novel;NRAS gene;Obesity;Oncogenes;Oncogenic;Patients;prevent;Primary carcinoma of the liver cells;Process;Production;recruit;Regulatory T-Lymphocyte;Research;Role;Serum;Signal Transduction;success;T-Cell Depletion;Techniques;Testing;Therapeutic;therapeutic miRNA;therapeutic target;Thymoma;Time;transcriptome;Transplantation;tumor;Tumor Burden;Tumor Immunity;Viral Oncogene

PROJECT_TITLE: MicroRNA-15a/16-mediated cytokine/chemokine reprogramming in Kupffer cells prevents the development of hepatocellular carcinoma

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Lung;Prevention;Pulmonary Fibrosis;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Narrative In recent decades, genome-wide association studies (GWAS) have identified genetic variants associated with a variety of traits and diseases, a critical first step towards understanding the molecular mechanisms that underlie common health conditions. In many cases, however, the functions of GWAS genes, the mechanisms and consequences of their dysfunction, or the relevant cell types in which their dysfunction manifests a clinically significant phenotype remain poorly understood. This application applies a combination of bioinformatic analysis, human induced pluripotent stem cell modeling, and mouse studies to elucidate the molecular mechanisms by which the GWAS gene DSP modulates function of type 2 alveolar epithelial cells and contributes to the pathogenesis of pulmonary fibrosis.

PI_NAMEs: WILSON, ANDREW A (contact);ZHOU, ANNY XIAOBO

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: 6p24;Adherens Junction;Adult;Affect;AGTR2 gene;Alveolar;alveolar epithelium;armadillo proteins;ATAC-seq;Binding;Bioinformatics;Biological Assay;Biological Models;Biology;Bleomycin;causal variant;Cell Differentiation process;Cell Maturation;cell type;Cells;Chronic Obstructive Pulmonary Disease;cigarette smoke;CISH gene;Cleavage Under Targets and Release Using Nuclease;clinically significant;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR interference;CRISPR-mediated transcriptional activation;Data;desmoplakin;Desmosomes;Disease;disease model;Disease susceptibility;disorder risk;Distal;Epithelial Cells;Epithelium;experience;Family member;fibrotic lung;Functional disorder;Gene Expression;Genes;Genetic study;genetic variant;Genome;genome wide association study;Health;Heart;Homeostasis;Human;human induced pluripotent stem cells;human subject;Impairment;in vivo;induced pluripotent stem cell;Injury;Intercellular Junctions;knock-down;Knock-out;Label;Link;Linkage Disequilibrium;Lung;Lung Diseases;lung injury;Mechanical Stress;Mediating;Mesenchymal;Modeling;Molecular;Mus;Nuclear;Organoids;overexpression;Participant;Pathogenesis;Pathway Analysis;Pathway interactions;Patients;Phenotype;Physiological;plakoglobin;Play;Preparation;Probability;Proteins;Protocols documentation;Publishing;Pulmonary Fibrosis;Regenerative capacity;regenerative cell;Respiratory Disease;response;Risk;risk variant;Role;Sampling;Signal Transduction;single cell sequencing;Skin;stem cell function;stem cell model;Structure of parenchyma of lung;Testing;Tissues;trait;transcription factor;transcriptome sequencing;transcriptomics;transdifferentiation;transgene expression;translational potential;Variant

PROJECT_TITLE: Mechanistic studies of the genetic contribution of desmoplakin to pulmonary fibrosis in alveolar type 2 cells

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Eukaryotic genomes are packaged in chromatin. This proposal aims to elucidate the interplay between chromatin organization, remodeling and modification and two key nuclear functions: gene transcription and DNA repair, using single molecule imaging in living cells and light-based manipulation of genome.

PI_NAMEs: HA, TAEKJIP  (contact);JOHNSON, MARGARET ELLEN;WU, CARL

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Affect;Architecture;Base Excision Repairs;Binding;Biological;Cell Nucleus;Cells;Chromatin;Chromatin Fiber;Chromatin Modeling;chromatin modification;Clustered Regularly Interspaced Short Palindromic Repeats;Computer Models;Data Set;DNA;DNA Damage;DNA Repair;DNA Repair Enzymes;DNA Repair Gene;Double Strand Break Repair;Drosophila genus;Elements;Experimental Models;Genes;Genetic Transcription;Genome;genome-wide;genomic locus;Heat-Shock Response;Hemocytes;Human;Image;Kinetics;Knowledge;Label;Light;Link;Mediating;Messenger RNA;Mismatch Repair;Modeling;Modification;molecular imaging;Motion;Mus;mutant;non-histone protein;Nuclear;Nucleosomes;Outcome;Pathway interactions;Process;promoter;Proteins;real-time images;Regulation;Relaxation;repaired;Resolution;response;Series;single molecule;spatiotemporal;submicron;System;Testing;Theoretical model;theories;Time;transcription factor

PROJECT_TITLE: Chromatin Function During Transcription and DNA Repair at Single Molecule Resolutionin Living Cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-A(70)R]


NIH_SPENDING_CATS: Hematology;Kidney Disease;Rural Health

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PI_NAMEs: POLLOCK, DAVID M (contact)

PROJECT_TERMS: Alabama;Area;Award;Basic Science;career;Clinical;Clinical Sciences;Collaborations;Communities;Deep South;design;Development;Discipline;Disease;Education;Engineering;Ensure;Epidemiology;experience;Extramural Activities;Fellowship Program;Fostering;Funding;Future;Goals;Hematology;Individual;Institution;Instruction;Interdisciplinary Study;interest;Kidney;Knowledge;knowledge base;Leadership;Learning Skill;Medical;Mentors;Mission;Modernization;Nephrology;Non-Malignant;Operative Surgical Procedures;Pediatrics;peer;Population Sciences;Postdoctoral Fellow;pre-doctoral;Process;programs;Public Health Schools;recruit;Research;Research Personnel;Research Training;Residencies;Resources;Science;skills;success;System;Talents;TNFSF15 gene;Training;Training and Education;Training Programs;Training Support;Translational Research;Underrepresented Populations;Universities;urologic;Urology;Work;Writing

PROJECT_TITLE: Deep South KUH Premier Research - Interdisciplinary Mentored Education (PRIME) Training Core


NIH_SPENDING_CATS: Infectious Diseases;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative  The common sexually transmitted protozoan pathogen, Trichomonas vaginalis, colonizes the genital tract and causes hundreds of millions of infections worldwide. Treatment of trichomoniasis is with oral nitro drugs, but they can have significant adverse effects, resistance is a manifest clinical problem, and no therapeutic alternatives are approved. The project will conduct the critical pre-clinical studies to establish proteasome inhibitors as new agents in the therapeutic armamentarium against this common and clinically important cause of parasitic disease.

PI_NAMEs: ECKMANN, LARS  (contact);O'DONOGHUE, ANTHONY JOHN

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Acute;Adverse effects;adverse pregnancy outcome;anti-microbial drug;antimicrobial;Appearance;Benign;Biochemical;Biological Assay;Biology;Cell Line;Cells;Chemistry;Clinical;Cryoelectron Microscopy;cytotoxicity;Data;design;Development;Disease;Disease Outcome;drug candidate;drug development;Drug Kinetics;Drug resistance;efficacy testing;Encephalopathies;Evaluation;experience;FDA approved;Fluorogenic Substrate;Genitourinary System Infection;Hela Cells;HIV;Human;improved;In Vitro;in vitro activity;in vivo;in vivo evaluation;Incidence;Infection;inhibitor;Investigation;Lead;Libraries;Malignant neoplasm of cervix uteri;Malignant neoplasm of prostate;Mammalian Cell;Measures;Medicine;men;Meningitis;Metallic Tastes;Metronidazole;Microbe;Modeling;Modification;mouse model;Mucous Membrane;multicatalytic endopeptidase complex;Mus;Muscle Cramp;Nausea;New Agents;new therapeutic target;novel;Oral;Oral Administration;Parasites;Parasitic Diseases;Parasitology;pathogen;Patients;peptide drug;Peptide Hydrolases;Peptides;Peripheral Nervous System Diseases;Pharmaceutical Chemistry;Pharmaceutical Preparations;preclinical study;Prevalence;Proteasome Binding;Proteasome Inhibitor;Protein Complex Subunit;protein degradation;Proteins;Recycling;reproductive tract;Research Personnel;Resistance;Resistance development;resistant strain;Resolution;Risk;Route;Severities;Sexual Transmission;Sexually Transmitted Diseases;side effect;Stomach;Structure;Substrate Specificity;Testing;Therapeutic;therapy resistant;Tinidazole;Topical application;Toxic effect;Toxicity Tests;transmission process;Treatment Failure;Trichomonas Infections;Trichomonas vaginalis;urogenital tract;Vagina;Woman

PROJECT_TITLE: Proteasome inhibitors against mucosal protozoan pathogens

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-Y(83)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Infectious Diseases;Neurodegenerative;Neurosciences

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

PHR: Understanding the mechanistic factors that contribute to Alzheimer’s Disease (AD) progression is essential to promote healthy aging. Pathogens are correlated to cognitive decline but a causative link is lacking. Cytomegalovirus (CMV) infection can result in rewiring of metabolic pathways. In this proposal, we will test the hypothesis that repeated CMV infection alters blood brain barrier metabolism, accelerating AD progression.

PI_NAMEs: ZWEZDARYK, KEVIN JOHN (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: 3xTg-AD mouse;Acceleration;acute infection;Address;Age;age acceleration;Age Months;age related;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;American;Amyloid beta-Protein;Amyloid deposition;Apoptosis;Automobile Driving;Biological Assay;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier permeabilization;brain endothelial cell;Calcium;Caregivers;Cell Reprogramming;Cell Separation;Cells;Cerebrum;Characteristics;Chronic;Clinical;Clinical Trials;Cognitive;cognitive ability;cognitive function;cognitive testing;Consensus;cytochrome c;Cytomegalovirus;Cytomegalovirus Infections;Data;Dependence;Development;disease phenotype;Disease Progression;Elderly;emerging pathogen;Epidemiology;Etiology;experience;experimental study;Exposure to;Extravasation;flexibility;Flow Cytometry;Frequencies;Functional disorder;Genetic Risk;Genus Hippocampus;Glycolysis;healthy aging;Herpesviridae;Human;Immunofluorescence Immunologic;Impaired cognition;improved;In Vitro;Inbred BALB C Mice;Individual;Infection;infection burden;Inflammation;inhibitor;Iron;Life;Link;Lysosomes;Measures;Mediating;Mediator;Metabolic;metabolic abnormality assessment;Metabolic dysfunction;Metabolic Pathway;metabolic phenotype;metabolic profile;Metabolism;mild cognitive impairment;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Modeling;mouse model;Mus;Nerve Degeneration;Neurologic Symptoms;neuron loss;Neurons;neuropathology;novel therapeutic intervention;novel therapeutics;older adult;Onset of illness;Organism;Outcome Study;Output;Oxidative Phosphorylation;Oxidative Stress;Oxidative Stress Induction;pathogen;pathogen exposure;Pathologic;Pathway interactions;Patients;PECAM1 gene;Peptides;Permeability;Phenotype;Population;pre-clinical;preference;prevent;Protein Analysis;protein expression;release of sequestered calcium ion into cytoplasm;Reporting;Risk;Risk Factors;Role;Stress;success;Superoxides;Supporting Cell;Testing;Tight Junctions;Tropism;Ubiquitination;Viral;Viral Load result;Virus;Virus Diseases;Voltage-Dependent Anion Channel;Western Blotting;Work

PROJECT_TITLE: The Role of Viral Exposure and Age in Alzheimer's Disease Progression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Z(55)R]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative The goal of this project is to understand why bariatric surgery is such an effective treatment for obesity with a focus on brain mechanisms. Cerebrospinal fluid neuropeptide, hormone and protein levels will be measured as a surrogate for changes in brain activity in subjects before and after bariatric surgery as compared with subjects before and after diet-induced weight loss. Understanding how the central nervous system responds to bariatric surgery could facilitate the development of alternative nonsurgical therapies for obesity and its metabolic complications.

PI_NAMEs: KORNER, JUDITH ;WARDLAW, SHARON L. (contact)

PROGRAM_OFFICER_NAME: WOO, THERESA TESLOVICH

PROJECT_TERMS: Address;Affect;antagonist;ART protein;bariatric surgery;beta-Endorphin;Biochemical;Biological Markers;Body mass index;Body Weight decreased;Brain;brain pathway;Central Nervous System;Cerebrospinal Fluid;Communication;Cortisone;Data;Development;Diet;Dopamine;effective therapy;energy balance;feeding;FGF19 gene;Gastrectomy;Gastric Bypass;ghrelin;glucagon-like peptide 1;Goals;Hormonal;hormonal signals;Hormones;Human;Hydrocortisone;hypothalamic-pituitary-adrenal axis;innovation;Intervention;Leptin;leptin receptor;Liquid substance;Measurement;Measures;Mediating;Metabolic;Metabolism;Methods;monoamine;mu opioid receptors;Neurons;Neuropeptides;neurotransmission;Neurotransmitters;new therapeutic target;novel;obese person;Obesity;obesity treatment;Operative Surgical Procedures;Opioid;Pathway interactions;Pattern;Peptides;Peripheral;Plasma;Play;Pro-Opiomelanocortin;Process;prohormone;Proteins;Proteomics;response;Rewards;Role;Serotonin;Signal Transduction;System;Testing;Therapeutic

PROJECT_TITLE: Changes in CSF Biomarkers after Bariatric Surgery

STUDY_SECTION: CIDO

STUDY_SECTION_NAME: Clinical and Integrative Diabetes and Obesity Study Section[CIDO]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Lung;Neonatal Respiratory Distress;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

ORG_CITY: WILMINGTON

ORG_NAME: NEMOURS CHILDREN'S HOSPITAL, DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE Bronchopulmonary dysplasia (BPD) is a serious chronic lung disease of premature babies that causes life-long cardiorespiratory morbidities and there are no effective treatments available to prevent or treat this disease. Infants who died because of BPD have increased levels of Cellular communication network factor 2 (CCN2) in their lungs. This study will use animal models to evaluate the function of CCN2 in lung cells during normal lung development and during disease, and evaluate whether decreasing the production of CCN2 in lung cells will prevent BPD.

PI_NAMEs: ALAPATI, DEEPTHI  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: 3-Dimensional;Abnormal Cell;Address;Adverse effects;Affect;Alveolar;alveolar epithelium;Animal Model;antagonist;Attenuated;Basic Science;Bioinformatics;Biological Assay;Bronchopulmonary Dysplasia;Candidate Disease Gene;career;Cause of Death;Cell Communication;Cell Lineage;Cell Physiology;cell type;Cells;Characteristics;Chronic lung disease;Clinical;clinical care;Coculture Techniques;collaborative environment;combinatorial;Communication;Complex;CRISPR/Cas technology;Data Set;Death Rate;Disease;DNA;effective therapy;Endothelial Cells;Endothelium;Environment;Epithelial Cells;Epithelium;Equilibrium;experience;experimental study;Exposure to;Extracellular Matrix;Fibroblasts;Future;gene editing technology;Gene Expression;Genes;Genetic;genetic manipulation;Goals;hospital readmission;Hyperoxia;hyperoxia induced lung injury;Impairment;improved;in utero;In Vitro;Infant;innovation;insight;Integrins;International;knock-down;Knock-out;Knockout Mice;Label;Laboratories;Lung;lung development;Lung Diseases;lung injury;lung regeneration;lung repair;Master of Science;Mediating;Mentors;Mentorship;Mesenchymal;Modeling;Modification;Molecular;Monoclonal Antibodies;Morbidity - disease rate;mouse model;Mutation;Neonatal;neonatal lung disease;Neurodevelopmental Impairment;new therapeutic target;novel;novel strategies;novel therapeutics;Outcome;overexpression;Pathologic Processes;Pathway interactions;Pediatric Hospitals;Pennsylvania;Phenotype;postnatal;Premature Infant;prevent;Prevention;Prevention therapy;Production;Productivity;Proteins;Rattus;Reagent;Repression;Research;Research Personnel;Research Proposals;Resources;response;Role;Route;Scientist;selective expression;Signal Transduction;single-cell RNA sequencing;skills;spatiotemporal;System;targeted treatment;Therapeutic;Therapeutic Agents;therapeutic genome editing;Time;tool;Training;Training Programs;Transgenic Organisms;Translational Research;Universities;Vascularization;Wild Type Mouse

PROJECT_TITLE: Role of alveolar epithelial cell-derived cellular communication network factor 2 (CCN2) in alveologenesis and bronchopulmonary dysplasia

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Project Narrative – MAE-WEST SCORE Overall Women compared to men experience an excess of burden of age-related diseases of the heart, brain, and kidney for reasons that remain unclear. Growing evidence points to the potential importance of chronic inflammation and small blood vessel dysfunction as key determinants of the sex differences seen in age-related disease outcomes. Therefore, we will establish a Specialized Center of Research Excellence focused on comprehensively investigating sex differences in the molecular drivers of chronic inflammation, microvascular aging, and end-organ disease. !

PI_NAMEs: BAIREY MERZ, CATHLEEN NOEL;CHENG, SUSAN  (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Acceleration;Address;Advocacy;Age;age difference;Age disparity;age effect;age related;age related changes;age-related disease;Aging;Alzheimer's disease related dementia;Awareness;Basic Science;Bioinformatics;Biological;Blood Vessels;Body System;Brain;Brain Diseases;burden of illness;Cardiology;Cardiovascular system;career;Cell Physiology;Centers of Research Excellence;Chronic;Chronic Disease;Chronic Kidney Failure;clinical development;clinical phenotype;Clinical Sciences;cohort;Communities;Data;Development;Disease;Disease Outcome;Education;effective intervention;EFRAC;Eicosanoids;Endothelial Cells;Enrollment;Epidemiologist;Evaluation;Exhibits;experience;Experimental Models;FDA approved;Female;forward genetics;Foundations;frailty;functional decline;Functional disorder;Funding;Geriatrics;Goals;Health;healthspan;Heart;Heart Diseases;Heart failure;heart function;Human;improved;In Vitro;Incidence;Individual;Inflammation;Inflammatory;Infrastructure;innovation;insight;Kidney;Kidney Diseases;Leadership;Life Cycle Stages;life span;Lipids;Longevity;male;Mass Spectrum Analysis;Measures;Mediating;Mediator;Medical;men;Mentors;Mentorship;microvascular aging;Microvascular Dysfunction;Molecular;multidisciplinary;Nature;Nephrology;Neurocognitive;next generation;novel therapeutic intervention;operation;Organ;Organ Model;Organism;Outcome;Pathway interactions;Pharmaceutical Preparations;Phenotype;Physiology;Plasma;Population Sciences;Positioning Attribute;preservation;Process;programs;prospective;rate of aging;receptor;Receptor Activation;Renal function;Request for Applications;Research;Research Personnel;Research Project Grants;Resources;response;Role;Sampling;Science;Scientific Advances and Accomplishments;Scientist;Secure;sex;Sex Differences;sex disparity;sexual dimorphism;Signal Transduction;Specialized Center;stressor;Structure;Syndrome;System;systemic inflammatory response;Therapeutic;Training;trait;translational scientist;Variant;Whole Organism;Woman;women versus men;Women's cohort;Women's Health;Work

PROJECT_TITLE: The Microvascular Aging and Eicosanoids - Women's Evaluation of Systemic Aging Tenacity (MAE-WEST) ("You are never too old to become younger!") Specialized Center for Research Excellence (SCORE)


NIH_SPENDING_CATS: Aging;Cardiovascular;Kidney Disease;Women's Health Research

PHR: Project Narrative – MAE-WEST SCORE LAC With advancing age, women and men age differently; women suffering more from Alzheimer’s disease and related dementias, heart failure with preserved ejection fraction, chronic kidney disease, and frailty. Recent work suggests that small blood vessel-related aging driven by chronic low-grade inflammation may be responsible for these aging disparities for women. The Leadership Administrative Core (LAC) in the Microvascular Aging and Eicosanoids – Women’s Evaluation of Systemic aging Tenacity (MAE-WEST) (“You are never too old to become younger!”) Specialized Center of Research Excellence (SCORE) on Sex Differences will oversee the program operations, communications, budgets and regulatory practices to optimize the translation of findings to improve public health.

PI_NAMEs: BAIREY MERZ, CATHLEEN NOEL (contact)

PROJECT_TERMS: Address;Administrative Coordination;Administrative Efficiency;Advisory Committees;Advocate;Age;age difference;age effect;age related;age-related disease;Aging;aging related;Alzheimer's disease related dementia;Annual Reports;Area;Basic Science;Bioinformatics;Biological Aging;Biostatistics Core;Blood Vessels;Brain;Budgets;Cardiology;career;career development;Centers of Research Excellence;Chronic;Chronic Kidney Failure;Chronology;Clinical;clinical development;Clinical Research;Clinical Sciences;Collaborations;Communication;Communities;data dissemination;Data Set;data sharing;Databases;Disease;Disease Outcome;disparities in women;Education;Educational Curriculum;Educational workshop;effective intervention;EFRAC;Eicosanoids;Elderly;Ensure;Epidemiologist;Evaluation;experience;Feedback;Female;Financial Support;Foundations;frailty;Functional disorder;Funding;Generations;Geriatrics;Goals;Gonadal Steroid Hormones;Grant;Heart failure;heart function;Human;improved;Inflammation;Inflammatory;Infrastructure;Institution;inter-institutional;Interdisciplinary Study;Investigation;Lead;Leadership;Letters;Life Cycle Stages;Longevity;male;Mediator;meetings;men;Mentors;microvascular aging;Microvascular Dysfunction;Mission;Monitor;Morbidity - disease rate;Nature;Nephrology;next generation;operation;Organ;organizational structure;Participant;Pilot Projects;Population Sciences;Preparation;preservation;Productivity;programs;Progress Reports;Public Health;public repository;Publications;rate of aging;Renal function;Reporting;Request for Applications;Research;Research Personnel;Research Project Grants;Resource Allocation;Resource Sharing;Resources;response;Scientific Advances and Accomplishments;scientific organization;Scientist;Services;sex;sex as a biological variable;Sex Differences;sexual dimorphism;shared repository;Specialized Center;stressor;Structure;Training;Training Activity;Translating;translational potential;translational scientist;Translations;Variant;Woman;Women's Health;Work

PROJECT_TITLE: MAE-WEST SCORE Leadership Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMNR-A]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Neurodegenerative;Neurosciences;Women's Health Research

PHR: Project Narrative – MAE-WEST SCORE CEC With advancing age, women and men age differently; women suffering more from Alzheimer’s disease and related dementias, heart failure with preserved ejection fraction, chronic kidney disease, and frailty. Recent work suggests that small blood vessel-related aging driven by chronic low-grade inflammation may be responsible for these aging disparities for women. The Career Enhancement Core (CEC) in the Microvascular Aging and Eicosanoids – Women’s Evaluation of Systemic aging Tenacity (MAE-WEST) (“You are never too old to become younger!”) Specialized Center of Research Excellence (SCORE) on Sex Differences will provide expert training in areas that include: population health, clinical trials, basic science, chemistry, biostatistics and bioinformatics, dementia testing, physiology, and frailty measurement, expanding the reach of the SCORE, and training the next generation of researchers to continue to improve public health.

PROJECT_TERMS: Address;Advocate;Age;age difference;age effect;age related;age-related disease;Aging;aging related;Alzheimer's disease related dementia;Analytical Chemistry;Area;Basic Science;Bioinformatics;Biological Aging;Biometry;Blood Vessels;Brain;California;Cardiology;career;career development;Career Mobility;Centers of Research Excellence;Chemistry;Chronic;Chronic Disease;Chronic Kidney Failure;Chronology;Clinical;clinical development;Clinical Trials;Collaborations;Communication;Communities;Data Analytics;Dementia;Development;Disease;Disease Outcome;disparities in women;Education;effective intervention;EFRAC;Eicosanoids;Elderly;Environment;Epidemiologist;Epidemiology;Evaluation;experience;Faculty;Female;frailty;Functional disorder;Funding;Geriatrics;Gerontology;Goals;Gonadal Steroid Hormones;Grant;hands on research;health difference;Heart;Heart failure;heart function;Human;implementation intervention;improved;Inflammation;Inflammatory;Infrastructure;infrastructure development;innovation;interdisciplinary approach;Life Cycle Stages;life span;Longevity;Measurement;Mediator;Medical;Medical center;men;Mentors;Methodology;microvascular aging;Microvascular Dysfunction;Mission;Molecular Profiling;Morbidity - disease rate;multidisciplinary;Nature;Nephrology;neurocognitive test;Neurology;next generation;Ophthalmology;Organ;Physiology;Pilot Projects;population health;preservation;Productivity;programs;Public Health;rate of aging;Renal function;Request for Applications;Research;Research Activity;Research Methodology;Research Personnel;Research Priority;Research Training;Resources;response;Scientific Advances and Accomplishments;Scientist;sex;sex as a biological variable;Sex Differences;sex disparity;sexual dimorphism;Specialized Center;stressor;Structure;Techniques;Testing;Training;Training Activity;Training and Education;Translating;translational potential;Translational Research;translational scientist;Translations;United States National Institutes of Health;Universities;Variant;Woman;Women's Health;Work

PROJECT_TITLE: MAE-WEST SCORE Career Enhance Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Cardiovascular;Dementia;Genetics;Human Genome;Kidney Disease;Neurodegenerative;Women's Health Research

PHR: Project Narrative – MAE-WEST SCORE Biostatistics and Bioinformatics Core With advancing age, women and men age differently; women suffering more from Alzheimer’s disease and related dementias, heart failure with preserved ejection fraction, chronic kidney disease, and frailty. Recent work suggests that small blood vessel-related aging driven by chronic low-grade inflammation may be responsible for these aging disparities for women. The Biostatistics and Bioinformatics Core (BBC) in the Microvascular Aging and Eicosanoids – Women’s Evaluation of Systemic aging Tenacity (MAE-WEST) (“You are never too old to become younger!”) Specialized Center of Research Excellence (SCORE) on Sex Differences will provide efficient analyses and generation of preliminary data for both early career, established researchers, and core activities, which will additionally contribute to the long-term sustainability of the MAE-WEST SCORE to improve public health.

PI_NAMEs: CHENG, SUSAN  (contact)

PROJECT_TERMS: Age;age difference;age effect;age related;age-related disease;Aging;aging related;Alzheimer's disease related dementia;Animals;Bioinformatics;Biological Aging;Biological Markers;Biometry;Biostatistical Methods;Blood Vessels;Brain;Cardiology;career;Cell membrane;Cells;Centers of Research Excellence;Chronic;Chronic Kidney Failure;Chronology;Clinical;clinical development;Complex;Data;Data Analyses;data management;Data Scientist;Data Sources;Dedications;Disease;Disease Outcome;disparities in women;effective intervention;EFRAC;Eicosanoids;Elderly;Endothelial Cells;Ensure;Epidemiologist;epigenomics;Evaluation;experience;Female;frailty;Functional disorder;Funding;Generations;Genomics;Geriatrics;Goals;Gonadal Steroid Hormones;Grant;Heart failure;heart function;high dimensionality;high throughput analysis;Human;improved;Inflammation;Inflammatory;Infrastructure;Knowledge;Leadership;Life Cycle Stages;Lipids;Longevity;male;Mass Spectrum Analysis;Mediating;Mediator;meetings;men;metabolomics;Methodology;Methods;microvascular aging;Microvascular Dysfunction;Morbidity - disease rate;Nature;Nephrology;Organ;Organization and Administration;Organizational Efficiency;Outcome;Pilot Projects;Plasma;preservation;programs;prospective;Proteomics;Public Health;Quality Control;rate of aging;Renal function;Request for Applications;Research Methodology;Research Personnel;Research Support;Resource Sharing;Resources;response;Science;Scientific Advances and Accomplishments;Scientist;Services;sex;Sex Differences;sexual dimorphism;small molecule;Specialized Center;Standardization;Statistical Data Interpretation;Statistical Methods;Stress;stressor;Structure;Techniques;tool;Training;trait;transcriptomics;translational potential;translational scientist;Variant;Woman;Work

PROJECT_TITLE: MAE-WEST SCORE Research Support Core - Bioinformatics Core


NIH_SPENDING_CATS: Aging;Kidney Disease;Women's Health Research

PHR: Project Narrative – MAE-WEST SCORE Eicosanoids Core With advancing age, women and men age differently; women suffer more from Alzheimer’s disease and related dementias, heart failure with preserved ejection fraction, chronic kidney disease, and frailty. Recent work suggests that small blood vessel-related aging driven by chronic low-grade inflammation may be responsible for these aging disparities for women. The Eicosanoid Profiling Core (EPC) in the Microvascular Aging and Eicosanoids – Women’s Evaluation of Systemic aging Tenacity (MAE-WEST) (“You are never too old to become younger!”) Specialized Center of Research Excellence (SCORE) on Sex Differences will analyses of pro and anti-inflammatory responses in the bloodstream to small vessel aging, maximize resource sharing across the project aims, and provide advanced research method training for early career investigators, which will additionally contribute to the long-term sustainability of the MAE-WEST SCORE to improve public health.

PI_NAMEs: JAIN, MOHIT  (contact)

PROJECT_TERMS: Acceleration;Acids;advanced analytics;Age;age difference;Age disparity;age effect;age related;age-related disease;Aging;aging related;aging related disease;Alzheimer's disease related dementia;Animal Model;Animals;antagonist;Anti-Inflammatory Agents;Arachidonic Acids;Basic Science;Bioinformatics;Biological;Biological Aging;Biological Assay;Biological Process;Biometry;Blood Circulation;Blood Vessels;Brain;burden of illness;Cardiology;career;Centers of Research Excellence;Chronic;Chronic Kidney Failure;Chronology;clinical development;Clinical Research;cohort;Collaborations;Complex;computational chemistry;Core Facility;cytokine;Data;data handling;data integration;data standards;Dedications;detection method;Development;Disease;disparities in women;drivers of aging;effective intervention;EFRAC;Eicosanoids;Eicosapentaenoic Acid;Elderly;Endothelial Cells;Endothelium;Ensure;Epidemiologist;Equilibrium;Evaluation;Exhibits;experience;Family;Female;Foundations;frailty;Functional disorder;Funding;Generations;Geriatrics;Goals;Gonadal Steroid Hormones;Grant;hallmarks of aging;Heart failure;heart function;high dimensionality;Human;improved;in vivo;indexing;Individual;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;Infrastructure;insight;Life Cycle Stages;Linolenic Acids;Lipids;liquid chromatography mass spectrometry;Longevity;male;Mass Spectrum Analysis;Measures;Mediator;men;Metabolic syndrome;Methodology;microvascular aging;Microvascular Dysfunction;Molecular;Morbidity - disease rate;Nature;Nephrology;novel;Obesity;Organ;Organization and Administration;Organizational Efficiency;Physiological;Pilot Projects;Plasma;Play;Polyunsaturated Fatty Acids;Population Study;preservation;prospective;Public Health;rate of aging;Renal function;Reproducibility;Request for Applications;Research Methodology;Research Personnel;Resolution;Resource Sharing;Resources;response;Risk;Role;Sampling;Scientific Advances and Accomplishments;Scientist;Services;sex;Sex Differences;sex disparity;sexual dimorphism;Specialized Center;Standardization;Stress;stressor;Structure;System;systemic inflammatory response;TNF gene;tool;Training;translational scientist;Variant;Woman;Work

PROJECT_TITLE: MAE-WEST RSC - Eicosanoids Profiling Core


ORG_CITY: CHICAGO

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: Project Narrative  The widespread use of antiretroviral therapy has significantly increased the lifespan of people living with HIV. Despite their effectiveness, there is a growing concern that antiretrovirals are the cause of a variety of comorbid conditions. The current proposal will investigate the role of antiretrovirals on bone loss and fat accumulation, two common conditions seen in HIV patients receiving antiretroviral treatment.

PI_NAMEs: ROSS, RYAN DEE (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: adipocyte differentiation;Adipocytes;adiponectin;Affect;AIDS clinical trial group;Animal Model;Anti-Retroviral Agents;antiretroviral therapy;Biological;Biological Markers;Body Composition;bone;bone cell;bone loss;bone mass;Cell Communication;Cell Culture Techniques;Cell Physiology;Cells;Chronic Disease;Clinical;Cohort Studies;Communication;comorbidity;Confounding Factors (Epidemiology);Data;defined contribution;Development;Dual-Energy X-Ray Absorptiometry;Effectiveness;experimental study;extend lifespan;Face;Fatty acid glycerol esters;Fumarates;Goals;High Prevalence;HIV;HIV Infections;Hormonal;Hormonal Change;Hormones;Human;human subject;humanized mouse;improved;In Vitro;Individual;inhibitor;insight;Insulin;Insulin Resistance;Integrase;Knowledge;Leptin;life span;Measures;Metabolic;Metabolic syndrome;mouse model;novel;novel therapeutics;Nucleosides;Nucleotides;Osteoblasts;Osteocalcin;Osteoporosis;Patients;Persons;Pharmaceutical Preparations;Plasma;pre-clinical;Prevalence;Production;Protease Inhibitor;Recommendation;Regimen;Research Personnel;response;Reverse Transcriptase Inhibitors;Risk;Ritonavir;Role;Sampling;skeletal;Stimulus;Study Subject;Tenofovir;Testing;Time;Tissues;Triglycerides;Weight Gain;Wild Type Mouse

PROJECT_TITLE: Bone and fat cross-talk in antiretroviral therapy (ART) treated HIV patients

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]