NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Prevention;Rare Diseases;Vector-Borne Diseases

PROJECT_TERMS: Acceleration;Address;Alpha Virus;Animals;Applied Research;Bacillus anthracis;biocontainment facility;biodefense;Biology;Biomedical Research;Brucella;Burkholderia;Caring;Centers for Disease Control and Prevention (U.S.);Collaborations;Communities;Computers and Advanced Instrumentation;Containment;Data;Diagnostic;Educational Curriculum;Electronics;Emergency Situation;Emerging Communicable Diseases;Ensure;Environment;Environmental Exposure;Equipment;experience;Facility Designs;Faculty;Francisella tularensis;Funding;Goals;good laboratory practice;Government;hands on instruction;Health;implementation strategy;improved;Individual;industry partner;Infrastructure;instrument;instrumentation;Knowledge;Laboratories;Laboratory Research;Marketing;meetings;member;Mission;Monitor;National Institute of Allergy and Infectious Disease;novel;operation;Orthobunyavirus;pandemic preparedness;pathogen;pathogenic bacteria;pathogenic virus;Plants;Positioning Attribute;Practice Guidelines;prevent;Procedures;Process;professional atmosphere;programs;Regulation;Reproducibility;Research;Research Activity;Research Personnel;Research Support;Rickettsia prowazekii;Risk;Safety;Secure;Services;skills;System;Therapeutic;Training;Training Programs;United States Department of Agriculture;Universities;Vaccines;Work;Yersinia pestis


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Prevention;Vector-Borne Diseases

ORG_CITY: FAIRFAX

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: GEORGE MASON UNIVERSITY

ORG_STATE: VA

PI_NAMEs: ALEM, FARHANG  (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;Address;Aerosols;Animal Experimentation;animal imaging;Animal Model;animal rule;Animals;anti-microbial peptide;Antigens;Bacillus anthracis;biocontainment facility;biodefense;Biodistribution;Biological Assay;Biological Models;Biomedical Research;Biotechnology;Body System;Brucella abortus;Brucella melitensis;Burkholderia mallei;Burkholderia pseudomallei;cell type;Chikungunya virus;Clinical;Clinical Trials;Communicable Diseases;Containment;Coronavirus;detection limit;Development;Diagnostic;diagnostic tool;DNA;Dose;Eastern Equine Encephalitis Virus;Evaluation;expectation;Fortification;Francisella tularensis;Funding;Human;human disease;immunoregulation;In Vitro;in vivo;in vivo Model;Infection;Infectious Diseases Research;Inflammatory;Institution;instrumentation;Investigational Drugs;Japanese encephalitis virus;Laboratories;Laboratory Research;lead optimization;lipid nanoparticle;Marketing;medical countermeasure;metabolomics;microphysiology system;Middle Eastern;Modeling;Modernization;Molecular;Mycobacterium tuberculosis;nanoparticle;Nanotechnology;National Institute of Allergy and Infectious Disease;New Drug Approvals;novel diagnostics;Organ;organ growth;organ on a chip;Organoids;pandemic preparedness;Particulate;pathogen;Pathogen detection;pathogenic bacteria;pathogenic virus;Peer Review;Pharmacologic Substance;Positioning Attribute;pre-clinical;preclinical development;preclinical study;preservation;priority pathogen;Process;Product Approvals;product development;Proteins;Proteomics;Publishing;Research;research faculty;Research Personnel;Research Priority;Research Support;Resources;respiratory;Rift Valley fever virus;RNA delivery;safety assessment;SARS coronavirus;Scientist;screening;Services;small molecule therapeutics;success;systems research;Technology;technology platform;Testing;therapeutic evaluation;Tissues;Toxic effect;Training;Universities;Vaccines;Validation;Venezuelan Equine Encephalitis Virus;Virus;Western Equine Encephalitis Virus;Yellow fever virus;Yersinia pestis

PROJECT_TITLE: Biocontainment Research support services core


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Arthritis;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Osteoarthritis;Pain Research

ORG_CITY: DAVIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Project Narrative The proposed research is relevant to public health as knee osteoarthritis is a leading cause of chronic pain and disability in older adults, and strategies are needed to reduce pain and improve physical function for individuals with this condition. The proposed research is relevant to the mission of NIA in that it focuses on a common health condition in the aging population and seeks to understand the clinical, behavioral, physiologic, and genetic mechanisms by which non-specific therapeutic effects impact health outcomes in this population. This line of research will improve outcomes in knee OA, and eventually other chronic and painful conditions, by developing and testing strategies to modify clinical care delivery to maximize non-specific effects associated with patient-clinician interactions and enhancing efforts to understand the role of non-specific effects in health outcomes.

PI_NAMEs: DOSSETT, MICHELLE L (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Adult;Adverse event;Affect;Age;aging population;Arousal;Arthritis;Behavior;Behavioral;Biochemical Pathway;care delivery;Catechols;Characteristics;Chronic;Chronic disability;chronic pain;chronic pain management;Clinical;clinical care;Clinical Trials;clinically relevant;common treatment;Communication;conditioning;Degenerative polyarthritis;design;Diclofenac;disability;Elements;ethnic diversity;Galvanic Skin Response;Gel;Genetic;Genetic Polymorphism;Genotype;Goals;Health;health communication;heart rate variability;Heartburn;High Prevalence;impression;improved;improved outcome;indexing;Individual;innovation;insight;Knee Osteoarthritis;knee pain;Length;Literature;Measures;Mediating;Medical;Mission;older adult;older patient;osteoarthritis pain;Outcome;Pain;pain catastrophizing;pain reduction;patient expectation;patient oriented;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Physical Function;Physiological;Physiology;Placebo Effect;Play;Polypharmacy;Population;provider behavior;Public Health;Publishing;racial diversity;Randomized;randomized trial;Research;response;Ritual compulsion;Role;Safety;Science;Self Efficacy;Smiling;standard of care;symptomatic improvement;Testing;Therapeutic Effect;Topical application;Transferase;treatment effect;Treatment outcome;Visit;Western Ontario and McMaster Universities Arthritis Index;Work

PROJECT_TITLE: The Effects of Visit Characteristics on Patient-Clinician Interactions and Health Outcomes in Knee Osteoarthritis

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Genetics;Heart Disease;Human Genome;Pediatric;Pediatric Cardiomyopathy;Rare Diseases

ORG_CITY: SEATTLE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Dilated cardiomyopathy (DCM) is one of the most prevalent inherited cardiac diseases, with its own unique phenotype and etiology, yet treatments for DCM are largely palliative and derived from other cardiac diseases. Although pharmacologic and mechanical treatments have been able to partially reverse the DCM phenotype, these results are often temporary, and growing evidence suggests that aberrant chromatin and matrix signals persist despite apparent healing from the whole organ level. This proposal aims to better define the time- dependent nature of DCM progression and reversibility by examining permanent epigenetic, structural, and functional changes in the myocardium.

PI_NAMEs: REICHARDT, ISABELLA  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Aftercare;Age;Age Months;ATAC-seq;Cardiac;Cardiology;Cardiovascular Diseases;Cardiovascular system;career;career development;Cells;Chromatin;chromatin remodeling;clinically relevant;Collagen;Congestive Heart Failure;Coupled;Cytoskeleton;Data;Deposition;Dilated Cardiomyopathy;Disease;DNA Methylation;Dose;Doxycycline;effective therapy;EFRAC;Engineering;Ensure;epigenetic memory;Epigenetic Process;epigenome;Etiology;experimental study;Extracellular Matrix;familial dilated cardiomyopathy;Family suidae;Fellowship;Fibroblasts;Fibrosis;Functional disorder;Future;Gene Expression;Generations;Genes;Genetic Transcription;Genome;Genomics;Goals;healing;Heart;Heart Diseases;Heart failure;heart function;Heart Hypertrophy;Human;Hypertrophy;improved;In Vitro;Induced Mutation;Inherited;inhibitor;Injury;Learning;Left ventricular structure;Link;mechanical stimulus;Mechanics;Medicine;Memory;Mentors;Mentorship;Mesenchymal Stem Cells;Microfilaments;Modeling;mouse model;multiple omics;Mus;Muscle Cells;mutant;Mutate;Mutation;Myocardial dysfunction;Myocardium;Myosin ATPase;Nature;Organ;Outcome;palliative;patient variability;Patients;Periodicity;pharmacologic;Pharmacological Treatment;Phenotype;Physicians;Point Mutation;pre-doctoral;pressure;professor;Progressive Disease;Proteomics;Repression;Research;Resolution;response;Running;Scientist;screening;Signal Transduction;skills;Structure;Symptoms;Technology;Testing;Therapeutic;therapeutic target;Time;tool;Training;transcriptome sequencing;transgene expression;Transgenic Mice;translational therapeutics;Treatment Failure;Troponin C;United States National Institutes of Health

PROJECT_TITLE: Investigating the Time-Dependent Reversibility of DCM-Induced Epigenetic, Matrix, and Functional Remodeling


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Rare Diseases

ORG_CITY: MAYWOOD

ORG_DEPT: BIOLOGY

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Patients with wild-type IDH glioblastoma (GBM) have a median age of onset at 68-70 years of age and represent >70% of all GBM diagnoses. Moreover, advanced age is a strong prognostic factor for predicting worse overall GBM patient survival. However, it's not understood as to why older age groups with GBM have a substantially worse survival outcome as compared to younger adults with GBM. This project aims to mechanistically understand how progressive aging negatively affects the survival outcomes in older adults with GBM.

PI_NAMEs: WAINWRIGHT, DEREK ALAN (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Address;Adult;Adult Glioblastoma;Affect;Aftercare;Age;age group;Age of Onset;age related;Age Years;Aging;Alzheimer's Disease;Animal Model;anti-cancer research;AP20187;Autopsy;Benign;Biological;Brain;Brain Neoplasms;brain tissue;CDKN2A gene;Cells;Central Nervous System;Central Nervous System Neoplasms;chemotherapy;Clinical;Clinical Trials;Cognitive;Dasatinib;Diagnosis;Elderly;Enrollment;enzyme activity;Enzyme Inhibitor Drugs;Enzymes;Excision;experience;Future;Gene Expression;Glioblastoma;Goals;Human;human old age (65+);Immunity;Immunosuppression;Immunotherapy;improved;in vivo;Individual;innovation;Isocitrate Dehydrogenase;Knockout Mice;Kynurenine;life span;Malignant - descriptor;Malignant neoplasm of brain;Malignant neoplasm of central nervous system;Malignant Neoplasms;Mediating;Metastatic Melanoma;MGMT gene;Modeling;Monoclonal Antibodies;mouse model;Mus;neuro-oncology;Neurology;Newly Diagnosed;Nivolumab;older adult;Outcome;Patients;pharmacologic;phase III trial;Predictive Factor;Primary Brain Neoplasms;Prognosis;Prognostic Factor;programmed cell death protein 1;promoter;quantification of aging;Quercetin;Radiation;Radiation therapy;Reporting;Research;Resected;response;senescence;senescent cell;senolytics;standard of care;Standardization;survival outcome;temozolomide;Testing;Therapeutic immunosuppression;therapy outcome;Tissues;Transgenic Model;Transgenic Organisms;Treatment Efficacy;Tryptophan;tumor;Tumor Bank;Universities;Wild Type Mouse;young adult

PROJECT_TITLE: Extratumoral biological determinants that decrease survival in older adults with glioblastoma

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative: The current proposal outlines a strategic plan to safely and effectively boost research productivity and innovative ground-breaking scientific discoveries in the UAB Southeastern Biocontainment Laboratory (SEBLAB). Upon completion, this project will achieve the following: 1) Support SEBLAB facility operational expenses; 2) Fund the leadership, administrative, and technical staff required to operate this high complexity facility, 3) Replace existing basic scientific equipment, 4) Support high quality BSL-3 biosafety training, 5) Establish integrated research cores within high containment, 6) Optimize and boost SEBLAB scientific research productivity, 7) Foster RBL/NBL network collaboration, and 8) Fund and maintain a highly skilled BSL-3 scientific workforce ready to rapidly respond at the frontline of emerging pandemic threats.

PI_NAMEs: LEAL, SIXTO MANUEL (contact)

PROGRAM_OFFICER_NAME: DIAZ SAN SEGUNDO, FAYNA C

PROJECT_TERMS: Air;Alabama;animal resource;Avian Influenza;Award;biobank;biocontainment facility;biodefense;Biomedical Research;career preparation;Cell Culture Techniques;Cell Line;Cell Separation;Cells;chikungunya;Collaborations;Containment;Core Facility;Coronavirus;COVID-19 pandemic;Decontamination;Development;Encephalitis Viruses;Equilibrium;Equine Encephalomyelitis;Equipment;exhaust;Flow Cytometry;Fostering;Funding;fungus;future outbreak;high resolution imaging;high throughput screening;Histoplasma;Human Resources;imaging platform;In Vitro;in vivo;Individual;Information Technology;innovation;Institution;Investments;Laboratories;laboratory facility;Laboratory Research;Leadership;Maintenance;medical countermeasure;medical specialties;Microbiology;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;new pandemic;non-invasive imaging;novel;Occupational Medicine;operation;Organism;Output;pandemic potential;pandemic preparedness;Police;Productivity;programs;Recovery;repaired;Research;research facility;Research Support;Risk;Scientist;Security;Services;skills;Solid;Specialist;Specimen;Strategic Planning;symposium;System;Technology;Training;training opportunity;Training Programs;Translating;Translational Research;Universities;Venezuelan Equine Encephalomyelitis;webinar;Work

PROJECT_TITLE: Enhancing SEBLAB Research Productivity, Operations and Core Laboratory Support


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Vector-Borne Diseases

PROJECT_TERMS: Aging;Air;Air Purifying Respirators;Alabama;animal resource;Animals;Avian Influenza;Award;Bathing;biocontainment facility;biodefense;biosecurity;Carbon Dioxide;chikungunya;Computers;Containment;Contract Services;Coronavirus;current pandemic;Decontamination;Dedications;Detection;Disinfectants;Emerging Communicable Diseases;Encephalitis Viruses;end of life;Ensure;Equilibrium;Equine Encephalomyelitis;Equipment;equipment acquisition;exhaust;Fostering;Funding;fungus;Future;high efficiency particulate air filter;high risk;Histoplasma;Human Resources;Incubators;infectious disease model;innovation;Investments;Laboratories;Leadership;Liquid substance;Maintenance;Microscope;Mission;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;new pandemic;Nitrogen;novel;operation;outreach;pandemic potential;pandemic preparedness;pandemic response;pathogen;Pathogenesis;personal protective equipment;Productivity;programs;Recovery;recruit;repaired;Research;Services;skills;Strategic Planning;System;Talents;Technology;Time;Training;Universities;Venezuelan Equine Encephalomyelitis;ventilation;Water;web site;Work;Workplace

PROJECT_TITLE: Facility Management, Maintenance and Operations Core


PROJECT_TERMS: Air;Alabama;animal resource;Avian Influenza;Award;Awareness;biocontainment facility;biodefense;biosecurity;certificate program;chikungunya;Complement;Containment;Coronavirus;COVID-19 pandemic;Decontamination;Dedications;Development;Educational workshop;Encephalitis Viruses;Ensure;Equilibrium;Equine Encephalomyelitis;Equipment;Exercise;exhaust;Extramural Activities;Funding;fungus;Future;high risk;Histoplasma;Human Resources;Individual;Information Technology;Institution;interest;Investments;Knowledge;Laboratories;laboratory experience;Laboratory Research;Maintenance;medical specialties;member;Mentors;Mission;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;new pandemic;Occupational Medicine;operation;pandemic potential;pandemic preparedness;pandemic response;Personnel Selection;Police;Policies;Process;Productivity;programs;Recovery;repaired;Research;Role;Safety;Scientist;Security;Services;Solid;Specialist;Specificity;Strategic Planning;Support Groups;support network;symposium;System;systematic review;Time;Training;training opportunity;Training Programs;Universities;Update;Venezuelan Equine Encephalomyelitis;Wages;webinar;Work;Workplace

PROJECT_TITLE: BSL-3 Practices Core


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Prevention;Wound Healing and Care

ORG_CITY: BOSTON

ORG_NAME: SCHEPENS EYE RESEARCH INSTITUTE

ORG_STATE: MA

PHR: The purpose of this research is to determine if a mitogen activated kinase (MAPK) inhibitor can prevent or reverse corneal scarring. There are currently no treatments to reverse a corneal scar, which results in a permanent loss of vision.

PI_NAMEs: CIOLINO, JOSEPH B. (contact)

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: Acceleration;Adverse effects;Aftercare;Animal Model;Back;Blindness;Cicatrix;Cornea;corneal epithelial wound healing;Corneal Injury;corneal scar;cytotoxicity;Disease;Ensure;Etiology;Evaluation;Eyedrops;FDA approved;Fibroblasts;Fibrosis;healing;Hematoxylin and Eosin Staining Method;Hour;Human;Impaired wound healing;In Vitro;in vitro Model;in vivo;Indirect Immunofluorescence;inhibitor;Injections;Injury;kinase inhibitor;Laceration;migration;Mitogens;Modeling;Myofibroblast;p38 Mitogen Activated Protein Kinase;Perforation;Phenotype;Phosphotransferases;Physiological Processes;prevent;Proliferating;Proteins;Puncture procedure;Rattus;repaired;Research;Research Design;Research Project Summaries;Safety;Signal Pathway;Sprague-Dawley Rats;Stains;Stromal Cells;Surgical incisions;Techniques;TGFB1 gene;Therapeutic;Therapeutic Effect;therapeutic target;Toxic effect;Transforming Growth Factor beta;Western Blotting;wound;Wound models

PROJECT_TITLE: VRC Inhibiting p38 to Prevent and Restore Corneal Scarring

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-T(90)S]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biomedical Imaging;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Vector-Borne Diseases

PROJECT_TERMS: Air;Alabama;Anesthesia procedures;animal imaging;Autopsy;Avian Influenza;Award;biobank;biocontainment facility;biodefense;bioluminescence imaging;Biomedical Research;career preparation;Cell Culture Techniques;Cell Line;Cell Separation;Cells;chikungunya;Clinical;Collaborations;Consultations;Containment;Core Facility;Coronavirus;COVID-19 pandemic;Decontamination;Development;Diagnostic tests;Drug Delivery Systems;Encephalitis Viruses;Equilibrium;Equine Encephalomyelitis;Equipment;Evaluation;exhaust;experimental study;Flow Cytometry;fluorescence imaging;Fostering;Funding;fungus;future outbreak;future pandemic;genetically modified cells;Genetically Modified Organisms;Genotype;High Resolution Computed Tomography;high resolution imaging;high throughput screening;Histoplasma;Human;imaging facilities;imaging platform;Immune response;Immunology;In Vitro;in vitro Assay;in vivo;in vivo imaging;Individual;Infection;innovation;insight;Institutional Review Boards;Investments;Laboratories;Laboratory Research;Light;Liquid substance;live cell imaging;Lung;medical countermeasure;Microbe;microbial;Microbiology;Microscopy;Mission;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;Nebulizer;new pandemic;non-invasive imaging;novel;operation;Organism;Output;pandemic potential;pandemic preparedness;Plaque Assay;Positron-Emission Tomography;Productivity;Pulmonary function tests;Recovery;repaired;Research;research clinical testing;Research Infrastructure;Research Support;Resolution;Resources;Risk;Sampling;Scientist;Senior Scientist;Services;single cell analysis;single photon emission computed tomography;skills;Solid;Strategic Planning;System;Technology;tissue processing;Translating;Translational Research;ultra high resolution;Universities;Variant;Venezuelan Equine Encephalomyelitis;Virus;Work;X-Ray Computed Tomography

PROJECT_TITLE: Biocontainment Research Support Service(s) Core-Optional


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: PROJECT NARRATIVE - OVERALL The New England Regional Biosafety Laboratory (NERBL) seeks to develop and maintain RBL containment staffing that is proficient in core competencies to support building, laboratory and vivarium operations, with embedded cross-training to ensure functional redundancies that sustain facility functions. Additionally, we will expand capacities and expertise in key infectious diseases including Mycobacterium tuberculosis and influenza. Achieving these milestones will ensure that the NERBL is sufficiently prepared to respond to pandemic and emerging disease threats as they arise.

PI_NAMEs: LONDON, CHERYL A;TELFORD, SAM R (contact)

PROJECT_TERMS: Address;Animal Model;Animal Welfare;Bacteriology;biocontainment facility;Biological Models;Biology;biosecurity;Categories;Certification;Communicable Diseases;Communities;Community Health Education;Community Outreach;Competence;Complement;Containment;contextual factors;Decontamination;design;Disease;Eastern Equine Encephalomyelitis;Education;Elements;Emerging Communicable Diseases;Emerging infection;Ensure;Environment;Environmental Health;Equipment;experience;Future;Goals;Health;Human Resources;Individual;Industry;industry partner;Infection;Infectious disease threat;Infectious Diseases Research;Influenza;Infrastructure;Institution;Knowledge;Laboratories;Laboratory Animal Medicine;laboratory manuals;Laboratory Research;Maintenance;medical countermeasure;member;Methods;Microbiology;Mission;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;New England;operation;Operations Research;pandemic disease;pandemic response;pathogen;pathogens of pandemic potential;Positioning Attribute;Postdoctoral Fellow;Powassan encephalitis;Preventive;Procedures;professor;Protocols documentation;public health emergency;Qualifying;repaired;Research;Research Assistant;Research Personnel;Research Support;Resource Development;Resources;response;Risk;Safety;Schedule;Schools;Scientist;screening;Services;skills;Specialist;System;Technical Expertise;Training;Tularemia;United States National Institutes of Health;Universities;vector;virology;Work;Workforce Development

PROJECT_TITLE: Resources and workforce development for the New England Regional Biosafety Laboratory


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

PI_NAMEs: TELFORD, SAM R (contact)

PROJECT_TERMS: Activities of Daily Living;Adherence;Air;Biological;biosecurity;Certification;Communication;Competence;Containment;Decontamination;Elements;Emergency response;Emergency Situation;Emerging infection;Ensure;Environmental Health;Equilibrium;Equipment;Extramural Activities;Funding;Future;Goals;Human Resources;improved;Individual;Infrastructure;Institution;Knowledge;Laboratories;Life Cycle Stages;Maintenance;member;Modification;Monitor;National Institute of Allergy and Infectious Disease;New England;operation;Pathogenicity;pathogens of pandemic potential;peer;Periodicals;Postdoctoral Fellow;preservation;Preventive;Procedures;programs;Qualifying;repaired;Reporting;Reproducibility;Research;Research Activity;Research Personnel;Resource Development;Resources;Risk Assessment;Safety;Secure;Services;skills;Specialist;Steam;success;System;Testing;Training;Universities;Work;Workforce Development

PROJECT_TITLE: NERBL Core 1: Facility Management, Maintenance and Operations


NIH_SPENDING_CATS: Infectious Diseases

PROJECT_TERMS: Accidents;Address;Animal Husbandry;Animal Welfare;Biological;biosecurity;Certification;Competence;Containment;data management;Decontamination;Defibrillators;Devices;Education;Elements;Emergency Situation;Emerging infection;Equipment;Equipment and supply inventories;Failure;Familiarity;Fire - disasters;First Aid;Funding;Future;Goals;Human Resources;Hygiene;improved;Individual;injured;Institution;Instruction;Knowledge;Laboratories;Life;Maintenance;Modeling;Natural Disasters;New England;new technology;operation;Outcome;pathogen;pathogens of pandemic potential;Performance;Periodicals;Procedures;Process;process improvement;programs;Research;Research Activity;Resource Development;response;Risk Assessment;Safety;Secure;Security;skills;Standardization;System;Technology;Time;Trainers Training;Training;Training Activity;Validation;Waste Management;Work;Workforce Development

PROJECT_TITLE: NERBL Core 2:  BSL-3 Practices


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Influenza;Pneumonia and Influenza;Rare Diseases;Tickborne Diseases;Tuberculosis;Vector-Borne Diseases

PROJECT_TERMS: Address;Aerosols;Animal Model;Animals;Area;Bacteriology;biobank;biocontainment facility;Biological Models;Biology;Communities;Competence;Culicidae;design;Development;Diagnosis;Disease;Eastern Equine Encephalomyelitis;effective intervention;Emergency response;Emerging infection;Ensure;Evolution;experience;Experimental Animal Model;Free Will;Genetic;Genetic Variation;genomic data;Goals;Human;Immunologic Markers;Immunology;Immunology procedure;improved;Industry;industry partner;Infection;Infectious Agent;Infectious Diseases Research;Influenza;influenzavirus;Intervention;Knowledge;Laboratories;Laboratory Research;Maintenance;medical countermeasure;meetings;member;Methodology;Modeling;mouse model;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;New England;new pandemic;novel;operation;Outcome;pandemic potential;pandemic preparedness;pandemic response;pathogen;pathogens of pandemic potential;Pathology;Phenotype;Powassan encephalitis;Powassan virus;pre-clinical;Preclinical Testing;Preparation;prevent;Procedures;programs;Proteomics;Public Health;Research;research clinical testing;Research Personnel;Research Support;Resource Development;Resources;respiratory;respiratory virus;response;Rodent Model;Sampling;screening;Services;skills;Technology;tick transmission;Tick-Borne Diseases;Ticks;Time;Training;transcriptomics;transmission process;Tuberculosis;Tularemia;United States National Institutes of Health;vaccine development;Variant;vector;vector transmission;Viral;virology;virtual;Virulence;Virus;Work;Workforce Development;Zoonoses

PROJECT_TITLE: NERBL Core 3:  Biocontainment Research Support Services


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Data Science;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention

ORG_CITY: CHICAGO

ORG_DEPT: CHEMISTRY

ORG_NAME: ILLINOIS INSTITUTE OF TECHNOLOGY

PHR: The primary objective of the proposed project is to develop a saliva-based biosensor by integrating research advances in sensing elements, machine learning, data analysis, microfluidics and communications for periodontal disease prediction which has high public health relevance. We will establish predictive models for periodontitis based on data from both sensor and patient. The new device will be useful for saliva-based self-monitoring for periodontitis and other oral or systemic diseases to improve the patient's overall health.

PI_NAMEs: MATHEW, MATHEW THOPPIL;WANG, RONG R. (contact)

PROGRAM_OFFICER_NAME: OKI, NOFFISAT

PROJECT_TERMS: Address;Adult;aged;Area;Artificial Intelligence;Awareness;Bioinformatics;Biological Markers;Biology;Biosensor;bone;bone loss;care systems;Caring;Categories;Clinical;clinical decision support;clinical examination;Collection;Communication;comorbidity;Computational Biology;computerized data processing;cost;craniofacial;Data;Data Analyses;data modalities;Data Reporting;Data Science;deep learning;Dental;Dentists;design;Detection;Devices;Diagnosis;Diagnostic;diagnostic value;Dimensions;Disease;disease diagnosis;disorder control;disorder risk;diverse data;Early Diagnosis;Elements;empowerment;Future;Goals;Health;Healthcare;Home;human subject;improved;indexing;Individual;individual patient;Inflammation;Inflammatory;innovation;Intervention;Knowledge;Lab On A Chip;Label;Learning;liquid biopsy;Machine Learning;machine learning framework;machine learning method;machine learning model;Measurement;Measures;Mediator;Medical;microbial;Microfluidic Microchips;Microfluidics;miniaturize;Modality;Monitor;Mouth Diseases;multimodality;nano;nanoparticle;nanopore;National Institute of Dental and Craniofacial Research;novel;Oral;oral care;Oral health;Output;Pain;Patients;Periodontal Diseases;Periodontitis;personalized medicine;point of care;Prediabetes syndrome;predictive modeling;Privacy;procedure cost;Process;programs;prototype;public health relevance;Research;risk prediction;Saliva;Salivary;Sampling;Secure;sensor;signal processing;Signal Transduction;soft tissue;solid state;Students;System;Systemic disease;teacher;tool;Tooth structure;Training;transmission process;user protection;user-friendly

PROJECT_TITLE: SCH: Multidimensional Microfluidic Salivary Sensor with Adversarial Knowledge Distillation for Point-of-Care Assessment of Periodontitis and Comorbidities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-N(50)]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Chronic Pain;Clinical Research;Hematology;Orphan Drug;Pain Research;Prevention;Rare Diseases;Sickle Cell Disease

ORG_CITY: San Carlos

ORG_NAME: IHP THERAPEUTICS, INC.

PHR: PROJECT NARRATIVE Current therapies for sickle cell disease largely fail to meet patient needs, particularly for the management of acute pain crisis associated with this devastating disease. Healthcare systems are largely ill-equipped for managing patients in the midst of these extremely painful and life-threatening events, leaving patients with medical distrust and no effective treatment option. We are therefore developing IHP-100, a novel P-selectin and complement inhibitor, for at-home self-management of pain crisis, which would represent a major paradigm shift in SCD treatment that empowers patients and provide significant freedom from disease.

PI_NAMEs: JOHN PADERI, JOHN PADERI JOHN PADERI (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Absenteeism at work;Acute;acute chest syndrome;Acute Lung Injury;Acute pain management;Address;Adhesions;Affect;Allergic Reaction;Antibodies;Anxiety;Area;Binding;Biological;Biological Assay;Biological Markers;Blood;Canis familiaris;Caring;Cause of Death;Cell Adhesion;Cells;Chemistry;Chronic;Clinical;clinical development;Clinical Trials Design;Complement;Complement Activation;Complement Inactivators;Complex;Cytolysis;design;Detection;Development;Disease;disease model;distrust;Dose;Early Intervention;early onset;Early treatment;effective therapy;empowerment;Endothelium;Engineering;Event;experimental study;Fatigue;Feedback;Feeling hopeless;fluorescence imaging;Freedom;Glutamine;health care service utilization;Healthcare Systems;Home;hydroxyurea;improved;In Vitro;in vivo;Infusion procedures;Intervention;Ischemia;Life;Life Expectancy;lung imaging;manufacture;Measures;Mediating;Medical;medication compliance;Mental Depression;Microfluidics;Migraine;Modeling;mouse model;Mus;novel;novel therapeutics;Organ;Outcome;P-Selectin;Pain;pain self-management;pain symptom;Pathology;Patients;Performance;Persons;Pharmaceutical Preparations;Phase;Polysaccharides;Positioning Attribute;potential biomarker;preclinical development;Productivity;prophylactic;Rattus;Reporting;Route;Schools;Selectins;Self Administration;Self Management;Serum;Sickle Cell;Sickle Cell Anemia;subcutaneous;Subcutaneous Injections;success;Testing;Therapeutic;therapeutically effective;Tissues;Toxic effect;Vascular Cell Adhesion Molecule-1;vaso-occlusive crisis;Work

PROJECT_TITLE: Development of a novel disease-modifying glycan therapeutic for early at-home intervention of acute vaso-occlusive crisis in sickle cell disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-C(10)B]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Hearing Loss;Neurosciences

ORG_CITY: ROOTSTOWN

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: NORTHEAST OHIO MEDICAL UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE Acetylcholine is a neurotransmitter that plays critical roles in normal hearing and helps the brain adapt during development, learning and aging and after damage to the nervous system. Understanding these functions is critical for developing approaches to help people with age-related hearing loss, difficulty understanding speech in noisy environments, learning to hear with cochlear implants or coping with hearing dysfunctions in disorders such as autism or schizophrenia. The present proposal will answer critical questions about the circuitry that underlies cholinergic function in the brainstem.

PI_NAMEs: SCHOFIELD, BRETT R (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acceleration;Acetylcholine;Acoustics;Address;Aging;Anatomy;Area;Arousal;Auditory;Auditory area;auditory feedback;auditory nuclei;auditory pathway;auditory processing;Auditory system;autism spectrum disorder;Axon;Brain;Brain Stem;Cavia;Cell Nucleus;cell type;Cells;Central Nervous System;cholinergic;Cholinergic Receptors;Cochlea;Cochlear Implants;Cochlear nucleus;Complex;coping;Data;design;Development;Disease;Ear;Environment;experimental study;Fluorescent in Situ Hybridization;Frequencies;Functional disorder;Future;Goals;Grant;Hearing;hearing impairment;Individual;Inferior Colliculus;insight;Knowledge;Label;Learning;Left;Long-Term Effects;Mediating;Methods;Midbrain structure;Muscarinic Acetylcholine Receptor;nerve supply;Nervous System;neuronal excitability;Neurotransmitters;Nicotinic Receptors;normal hearing;Pathway interactions;Pattern;Perception;Persons;Physiological;Play;Population;Presbycusis;prevent;receptor;Research;response;Rewards;Role;Schizophrenia;selective attention;sensory gating;Sleep Wake Cycle;Sound Localization;Source;Speech;Speech Discrimination;Speech Sound;Synapses;System;Tegmentum Mesencephali;Testing;Thalamic structure;Therapeutic;Tracer;Transgenic Animals;Transgenic Mice;Viral;Viral Vector

PROJECT_TITLE: Modulatory Circuits in the Auditory System

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Dental, Oral, and Craniofacial Disease;Microbiome

ORG_CITY: RICHARDSON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

ORG_STATE: TX

PHR: Project Narrative: Peri-implant (PI) diseases, mucositis and peri-implantitis, are triggered by dysbiosis of the oral microbiome, resulting in destructive host inflammatory immune response. Current PI disease treatment protocols are unpredictable and PI disease reoccurs in 42-58% of implants 5 years post treatment. Thus, in this study a multifunctional ionic liquid based dental implant coating technology will be further developed as a clinical treatment modality to target dysbiosis and immune imbalance during the onset of PI diseases.

PI_NAMEs: RODRIGUES, DANIELI  (contact)

PROGRAM_OFFICER_NAME: LOPEZ, ORLANDO

PROJECT_TERMS: Acute;Adsorption;Affect;Aftercare;Amino Acids;antimicrobial;Antimicrobial Resistance;aqueous;Bacteria;Bacterial Adhesion;Behavior;Biological Assay;biomaterial compatibility;bone;Bone Matrix;cell growth;Cells;Cellular Structures;Chemicals;Chitosan;Chlorhexidine;Chronic;Citric Acid;Clinical;clinical efficacy;Clinical Treatment;Coculture Techniques;confocal imaging;conventional therapy;Corrosion;Corrosives;Coupled;Debridement;Decontamination;Dental Implants;Deposition;Development;Disease;disease model;disease prognosis;Drug Metabolic Detoxication;dysbiosis;Enzyme-Linked Immunosorbent Assay;Equilibrium;Etiology;Evaluation;Excision;Exhibits;Fiber;Fibroblasts;Flow Cytometry;Formulation;Genetic Markers;Growth;healing;Histology;Hydrogen;hydrophilicity;Immune;Immune response;immunoregulation;Implant;implant coating;implant material;improved;In Vitro;in vitro testing;in vivo;Infection;Inflammation;Inflammatory;inflammatory milieu;Ions;Kinetics;Lasers;Ligature;Liquid Chromatography;Liquid substance;Lubricants;Lubrication;Macrophage;Mammalian Cell;Mechanics;Mediating;metallicity;Methods;Microbial Biofilms;microbiome;microbiome composition;microCT;migration;mineralization;Modality;Modeling;Molecular;Mucositis;novel;Optics;Oral;oral microbiome;organic acid;Osseointegration;osteoblast differentiation;oxidation;particle;pathogen;Pathogenicity;peri-implantitis;Phase;Phenylalanine;Plasma Proteins;polymicrobial biofilm;preservation;Procedures;Proteins;Proteome;Protocols documentation;Raman Spectrum Analysis;Rattus;Recurrence;Regimen;Research;Resolution;response;Roentgen Rays;Saline;Sampling;Scanning Electron Microscopy;Site;soft tissue;Spectrum Analysis;subcutaneous;Surface;Surface Properties;Symbiosis;tandem mass spectrometry;Taxonomy;Technology;Testing;Therapeutic;Therapeutic Agents;Tissues;Titanium;Treatment Protocols;Ultrasonics;ultraviolet;Up-Regulation

PROJECT_TITLE: Multifunctional Ionic Liquid Application for Treatment of Peri-implant Diseases


ORG_CITY: TUCSON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative  Aging and hearing loss (HL) is inexplicably tied. Here, we use optogenetics and pharmacogenetic strategies to determine HL mechanisms and biomarkers for treatment.

PI_NAMEs: YAMOAH, EBENEZER N (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: 3-Dimensional;Ablation;Address;Age;age related;age related changes;aged;Aging;aging auditory system;aging biomarker;Analytical Chemistry;Anatomy;Animal Model;Animal Sources;Animals;Auditory;Auditory area;Auditory Brainstem Responses;auditory pathway;Axon;Behavioral;Biochemical;Biological Markers;Biology;Brain;Brain Stem;Calcium;Cell Nucleus;Chronology;Clinical;clinically relevant;Cochlear nucleus;Code;Complex;Demyelinations;design;Dimensions;effective therapy;Electrophysiology (science);Ensure;Equilibrium;Etiology;Event;Exhibits;Functional disorder;functional plasticity;Genetic;Genetic Models;Hair Cells;hearing impairment;Human;Image;Imaging Techniques;in vivo;Individual;insight;Joints;Knock-in;Label;Labyrinth;Lead;Life Expectancy;Medial;Mental Depression;Modeling;Molecular;mouse model;Myelin;Nature;neural;neural network;neuron loss;Neurons;Noise-Induced Hearing Loss;optogenetics;Organelles;Outcome;Pathology;Personal Satisfaction;Pharmacogenetics;Phenotype;Physiology;Presbycusis;Productivity;programs;Proteome;Proteomics;Psychological Impact;Public Health;Pyramidal Tracts;Research Personnel;Resources;Sampling;Sensorineural Hearing Loss;Sensory;signal processing;Social isolation;Societies;sound;spiral ganglion;stem;Sum;Synapses;Synaptic plasticity;Testing;Time;tool;trapezoid body;treatment strategy;Work

PROJECT_TITLE: Determinants of age-induced hearing loss and reversal strategies


PHR: Project Narrative Age-related hearing loss (ARHL), often called presbycusis, is the most common neurosensory deficit in our aging population, but no FDA-approved drugs or therapeutic armamentarium for sensorineural hearing loss (HL) are available. The overall goals of the Administrative Core are to provide administrative services to all Projects and Cores to ensure programmatic, effective, efficient, and collaborative interactions of the investigative team.

PROJECT_TERMS: Action Potentials;Address;Advisory Committees;Affect;age related changes;Aging;aging auditory system;aging mechanism;aging population;Agreement;animal care;Auditory;Auditory area;auditory pathway;Biological Markers;California;Cellular biology;Clinical;Cochlear nucleus;Code;Communication;Complex;Consultations;Data Analytics;data hub;Data Science;Demyelinations;design;Detection;Disease;Ensure;excitotoxicity;FDA approved;Functional disorder;Genetic;Goals;Human Resources;Impaired cognition;Individual;Information Dissemination;Inhibitory Synapse;Iowa;Joints;Journals;Laboratories;Left;Link;medical schools;meetings;membrane model;Mental Depression;Modeling;Molecular;mouse model;Nature;Nerve Degeneration;neural network;neuron loss;Neurons;neurosensory;Nevada;Occupational activity of managing finances;Ohio;Outcome;outreach;Pacific Northwest;Persons;Pharmaceutical Preparations;Phase;Physiology;Pitch Perception;Presbycusis;Program Research Project Grants;Progress Reports;Property;Proteomics;Public Health;Publications;Quality of life;Reporting;Resource Sharing;Resources;response;Scheme;Sensorineural Hearing Loss;Services;Social isolation;sound;Source;Speech Intelligibility;Speed;spiral ganglion;Stimulus;Structure;Synapses;Synaptic plasticity;Testing;Therapeutic;Time;tool;Universities;Videoconferencing

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Genetics;Hearing Loss;Neurodegenerative;Neurosciences

PHR: Project Narrative The programmatic research program is proposing innovative mechanistic studies and will take advantage of genetically modified animal models to unravel significant fundamental and translational mechanisms underlying age-related hearing loss (ARHL). The Animal Core (Core B) will provide services for the generation, management, and distribution of aged and gene-targeted mouse models for all three projects, Core C and D.

PROJECT_TERMS: Action Potentials;Address;Affect;Age Distribution;age related;age related changes;aged;Aging;aging auditory system;aging population;animal facility;Animal Model;Animals;Auditory;Auditory area;auditory pathway;Auditory system;Backcrossings;Behavior;Binaural;Biological Markers;Brain Stem;Breeding;calbindin;calretinin;Clinical;Cochlear nucleus;Code;combat;Complex;Computer Analysis;cost effective;Cryopreservation;Demyelinations;design;Detection;Development;diphtheria toxin receptor;Disasters;Disease;Disease Outbreaks;excitotoxicity;Exhibits;experimental study;FDA approved;Functional disorder;Gene Targeting;Generations;Genes;Genetic;genetic approach;Genetically Engineered Mouse;Genetically Modified Animals;Genotype;Goals;handbook;Human;Impaired cognition;Individual;inducible Cre;Inhibitory Synapse;innovation;interest;Joints;Knock-in Mouse;Laboratories;Left;Link;Maps;Mental Depression;Modeling;Molecular;mouse model;Mus;Nerve Degeneration;neural;neural hearing loss;neural network;Neural Pathways;neuron loss;Neurons;neurosensory;novel;old mice;optogenetics;otoacoustic emission;Outcome;Persons;Pharmaceutical Preparations;Phase;Pitch Perception;Presbycusis;Program Research Project Grants;programs;progressive hearing loss;Property;Proteomics;Public Health;Quality of life;Research;Resources;response;Rodent;Role;senescence;Sensorineural Hearing Loss;Services;Social isolation;sound;Speech Intelligibility;Speed;Statistical Data Interpretation;Stimulus;Stretching;Synapses;Synaptic plasticity;Testing;Therapeutic;Tissues;tool;Transgenic Mice;United States National Institutes of Health

PROJECT_TITLE: Animal, Behavior and Tissue Core


ORG_CITY: BALTIMORE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The proposed project focuses on the development of a magnetofluidics-based platform amenable to HIV viral load self-testing for both detecting early acute infections and monitoring those people living with HIV/AIDS (PLWHA).

PI_NAMEs: HSIEH, YU-HSIANG ;MANABE, YUKARI C;ROTHMAN, RICHARD E;WANG, TZA-HUEI JEFF  (contact)

PROGRAM_OFFICER_NAME: ESPY, NICOLE JOY

PROJECT_TERMS: Acceleration;Accident and Emergency department;Accreditation;Acquired Immunodeficiency Syndrome;Acute;acute care;acute infection;AIDS prevention;amplification detection;antiretroviral therapy;Baltimore;Biological Assay;Blood;Buffers;Cellular Phone;Cessation of life;Charge;Chronic Disease;Clinic;Clinic Visits;Clinical;Clinical Management;Cold Chains;Collaborations;Communicable Diseases;Complex;Consent;Consumption;cost;Detection;detection assay;detection limit;Development;Devices;diagnostic technologies;Drug resistance;Early Diagnosis;Failure;FDA approved;Filtration;Fingers;Fluorescence;Freeze Drying;Goals;Health Policy;high risk population;HIV;HIV Infections;home test;Human immunodeficiency virus test;Hydration status;improved;Infection;instrument;instrumentation;Interruption;Intervention;Laboratories;Liquid substance;Magnetism;Manuals;manufacture;Membrane;Methods;Microfluidics;Miniaturization;miniaturize;Monitor;multidisciplinary;novel;nucleic acid purification;operation;particle;Patients;Performance;Persons;Phase;Plasma;portability;Preparation;prevent;Prevention strategy;Process;Protocols documentation;Public Health;Reaction;Reagent;reconstitution;Recording of previous events;resistance mutation;Resource-limited setting;response;RNA;RNA purification;Sampling;Schedule;Science;seal;Self Administration;self testing;Site;Surveys;Techniques;Technology;Test Result;Testing;Time;tool;Training;Translating;transmission process;Uganda;user-friendly;validation studies;Venipunctures;Viral;Viral Load result;viral rebound;Visit;Waxes;Whole Blood;World Health Organization

PROJECT_TITLE: Streamlined 15-min HIV Viral Load Self-Testing Using Finger-Stick Blood


PHR: Project Narrative: The purpose of Core C is to support the study of age-related hearing loss (ARHL) through a centralized resource of three-dimensional microscopy. The loss or structural remodeling of specific neurons and their components during aging will be identified in neuronal microcircuits from the inner ear to the brain's auditory centers.

PI_NAMEs: PERKINS, GUY A (contact)

PROJECT_TERMS: 3-Dimensional;Address;Affect;Age;age related;age related changes;aged;Aging;aging auditory system;aging population;Anatomy;Auditory;Auditory area;auditory pathway;Axon;Behavior;Biological Markers;Blinded;Brain;Brain Stem;brain tissue;CBA/CaJ Mouse;Cell Nucleus;Cells;cellular imaging;Chronology;Clinical;CNTNAP1 gene;Cochlea;Cochlear nucleus;Communication;Computers;Confocal Microscopy;connectome;cost effective;Data;Data Analyses;Dedications;Demyelinations;Dendrites;design;digital imaging;Dimensions;Disease;Electron Microscopy;Ensure;Event;excitotoxicity;Experimental Designs;experimental study;Face;FDA approved;Fluorescence;Functional disorder;Goals;Hair Cells;Human Resources;Image;Image Analysis;image archival system;image visualization;Imaging Device;Immunofluorescence Immunologic;Inhibitory Synapse;Inner Hair Cells;insight;Investigation;Joints;Knowledge;Label;Labyrinth;Length;Light;Link;Maps;Measurement;Medial;Microanatomy;Microscope;Microscopic;microscopic imaging;Microscopy;Mission;Mitochondria;Modeling;Molecular;Monitor;Mus;Myelin;nano;nanoscale;Nature;Nerve Degeneration;Nerve Fibers;neural;neural circuit;neural network;Neuroanatomy;neuron loss;Neurons;neurosensory;Online Systems;Outcome;Pattern;Peripheral;Persons;Pharmaceutical Preparations;Presbycusis;Proteins;Public Health;Pyramidal Tracts;quantitative imaging;reconstruction;Research;Research Personnel;Resolution;Resources;Scanning Electron Microscopy;Sensorineural Hearing Loss;Series;signal processing;Site;Source;Speed;spiral ganglion;Structure;Synapses;synaptic function;Synaptic plasticity;Synaptic Vesicles;synergism;Technology;Testing;Therapeutic;Thick;Time;tool;trapezoid body;web app

PROJECT_TITLE: Structural Analyses Core


PHR: Project Narrative Proteins mediate the bulk of cellular functions. Here, we will use innovative strategies to determine the up and down-regulated proteins in aging auditory neurons.

PI_NAMEs: PASA-TOLIC, LJILJANA  (contact)

PROJECT_TERMS: Action Potentials;Address;Affect;age related changes;aged;Aging;aging auditory system;aging population;aging process;aging related;Auditory;Auditory area;auditory pathway;Biochemical;Biochemistry;Biological Markers;Biological Process;blind;Cell Physiology;Cells;Cellular Structures;Clinical;Cochlear nucleus;Code;Complex;Cytometry;Demyelinations;design;Detection;Disease;excitotoxicity;FDA approved;Functional disorder;functional plasticity;Genetic;Immunohistochemistry;improved;Individual;Inhibitory Synapse;innovation;Joints;Liquid substance;Mass Spectrum Analysis;Measurement;Measures;Mediating;Modeling;Molecular;mouse model;Nature;Nerve Degeneration;neural;neural network;neuron loss;Neurons;neurosensory;neurotransmission;Outcome;Persons;Pharmaceutical Preparations;Phase;Pitch Perception;Post-Translational Protein Processing;Predisposition;Presbycusis;Process;Program Research Project Grants;Property;protein biomarkers;Proteins;Proteome;Proteomics;Public Health;Regulation;Resolution;Resources;response;RNA;Sensorineural Hearing Loss;single cell proteins;single-cell RNA sequencing;sound;Speech Intelligibility;Speed;spiral ganglion;Stimulus;Synapses;Synaptic plasticity;Techniques;Testing;Therapeutic;tool

PROJECT_TITLE: Proteomic Core D


PHR: Project Narrative:  Age-related hearing loss (ARHL) ranks first in the etiology of human sensory deficits. Here, we will determine the mechanisms by which loss of specific neurons, accompanied by remodeling of sound-sensitive auditory circuits, changes during aging, and how this information can be used to develop treatments for ARHL.

PROJECT_TERMS: Action Potentials;Address;Affect;Afferent Neurons;Age;age effect;age related;age related changes;age related decline;aged;Aging;aging mechanism;Anatomy;Auditory;Auditory area;Auditory Brainstem Responses;Backcrossings;Biological Markers;biophysical properties;Brain Stem;calbindin;calretinin;Cell Nucleus;Cochlea;Cochlear nucleus;Complex;Computer Analysis;Computer Models;Coupled;Demyelinations;density;Dependence;Development;Electrophysiology (science);Environment;Etiology;Evaluation;excitotoxicity;experimental study;Frequencies;Generations;Hair Cells;hearing impairment;Human;In Situ;Injections;Injury;insight;Ion Channel;Kinetics;Knock-in;Knock-in Mouse;Light;Maps;Measures;Mediating;Microscopy;Molecular;mouse model;Mus;Nerve Degeneration;neural;neuron loss;Neurons;neurosensory;Noise-Induced Hearing Loss;older adult;optogenetics;otoacoustic emission;patch clamp;Persons;Pharmacogenetics;Pharmacology;Phase;Phenotype;Physiological;Population;postsynaptic;Predisposition;Presbycusis;pressure;presynaptic;Process;Property;Reflex action;Resolution;response;Sensory;signal processing;Signal Transduction;sound;Speed;spiral ganglion;Stimulus;Synapses;Synaptic Vesicles;Variant;vector;Visualization;voltage;voltage clamp;Work

PROJECT_TITLE: Molecular and Functional Mechanisms of the aging auditory neuron


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Substance Misuse

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative Alcohol-associated liver disease (ALD) is a major socioeconomic burden in the United States with limited, ineffective therapeutic interventions. This proposal will identify MLKL as a key mediator in the regulation of the balance between hepatic immune cell pro-survival and pro-death signaling following ethanol exposure. The results will leverage these new mechanistic insights into the pathophysiology of ALD.

PI_NAMEs: WU, XIAOQIN  (contact)

PROGRAM_OFFICER_NAME: PERRUCCIO, ELIZABETH M

PROJECT_TERMS: Acute;alcohol exposure;alcohol response;Alcohol-Induced Disorders;Alcoholic Hepatitis;Alcoholic Liver Diseases;Anti-Inflammatory Agents;Apoptotic;Bone Marrow;Bone Marrow Transplantation;career;career development;Cell Culture Techniques;Cell Death;Cell model;Cell Survival;Cells;Cessation of life;Chimera organism;Chronic;Cirrhosis;Clinical;Communication;Complex;Data;Dedications;design;Development;Development Plans;Disease;Disease Progression;Economic Burden;Environment;Equilibrium;Ethanol;Exhibits;Exposure to;extracellular;Foundations;Functional disorder;Future;Heavy Drinking;Hepatic;Hepatitis;Hepatocyte;Heterogeneity;Histone H3;Homeostasis;Human;Immune;Immune response;in vivo;Infection;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Injury;injury and repair;insight;Intervention;Knock-out;Kupffer Cells;Liver;Liver diseases;liver inflammation;Macrophage;Maintenance;Measures;Mediating;Mediator;Mentors;Mentorship;Modeling;Molecular;monocyte;Morbidity - disease rate;Morphology;mortality;mouse model;Mus;Myeloid Cells;Natural Immunity;Necrosis;neutrophil;Outcome;Paper;Pathogenesis;Pathway interactions;Patients;Peripheral;Phase;Phenotype;phosphoproteomics;Phosphotransferases;Play;Population;Positioning Attribute;prevent;Primary carcinoma of the liver cells;Process;Productivity;professor;programs;recruit;Regulation;Research;Research Personnel;Resolution;response;response to injury;restoration;RIPK1 gene;RIPK3 gene;Role;S100A8 gene;Signal Transduction;skill acquisition;socioeconomics;Solid;Stains;Technical Expertise;Testing;Therapeutic Intervention;tissue injury;Tissues;Training;United States;Work

PROJECT_TITLE: Role of MLKL in Alcohol-associated Liver Disease

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: EB

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: NARRATIVE The Center for Label-free Imaging and Multiscale Biophotonics (CLIMB) develops cutting-edge optical and computational imaging technologies for addressing grand challenges in biomedicine, including cancer and neurodegenerative diseases. We developed a rigorous and inclusive technology training and dissemination plan, as well as a comprehensive educational program to prepare the next generation of biophotonics researchers for excelling in label-free imaging.

PI_NAMEs: BOPPART, STEPHEN A (contact)

PROGRAM_OFFICER_NAME: SHABESTARI, BEHROUZ

PROJECT_TERMS: Address;Adoption;Biological Markers;Biophotonics;Books;Chemicals;Clinic;clinical application;clinical practice;Clinical Research;Clinical Trials;Collaborations;commercialization;Communities;contrast imaging;Contrast Media;Cost Sharing;Decision Making;deep learning;diversity and inclusion;Education;Educational Materials;Educational workshop;Enrollment;Environment;Equipment;Evaluation;expectation;experience;Faculty;Feedback;Fellowship;Funding;Healthcare;Human;Image;imaging modality;Imaging technology;improved;in vivo;in vivo imaging;innovation;Label;Lead;Malignant Neoplasms;member;Microscopy;Minority Groups;Monitor;multimodality;Neurodegenerative Disorders;new technology;next generation;open source;operation;Optical Coherence Tomography;optical imaging;Optics;Phase;point of care;Postdoctoral Fellow;Procedures;Process;Productivity;Program Development;programs;Research;Research Personnel;residence;Resources;Schools;Series;service programs;Specificity;Specimen;Students;synergism;Technology;technology research and development;technology training;Time;tool;Training;Training Programs;Translating;Underrepresented Populations;webinar;Writing


NIH_SPENDING_CATS: Biotechnology

PROJECT_TERMS: Advisory Committees;Animals;Biomedical Engineering;Biophotonics;Communication;Communities;community center;computer infrastructure;Core Facility;Cost Sharing;Educational workshop;Equipment;Event;experience;Feedback;Funding;High Performance Computing;Image;Infrastructure;Institution;Interdisciplinary Study;International;Intranet;Label;Laboratories;meetings;member;Mission;operation;organizational structure;Performance;Phase;Procedures;Productivity;programs;Research;Research Personnel;Resource Sharing;Resources;Role;Running;Schools;Science;Side;Study Section;success;Technology;Training;Training and Education;United States National Institutes of Health;Visit

PROJECT_TITLE: The Center for Label-free Imagingand Multiscale Biophotonics (CLIMB)


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: BHARGAVA, ROHIT  (contact)

PROJECT_TITLE: Quantitative phase imaging andcomputational specificity (Popescu)


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Machine Learning and Artificial Intelligence

PROJECT_TERMS: adaptive optics;Algorithms;Apoptosis;Application procedure;Artificial Intelligence;Autophagocytosis;base;Binding;Biological;Biological Markers;biomedical imaging;Biophotonics;bioprocess;Biopsy Specimen;Cancer Detection;Catheters;Cell Death Process;Cells;Chemicals;Clinical;clinical imaging;Clinical Medicine;Clinical Trials;clinically relevant;Contrast Media;Decision Making;deep learning;design;Detection;Development;Diagnosis;Diagnostic;digital pathology;Disease;Dyes;Endoscopes;Engineering;FDA approved;Fiber;Financial cost;Histopathology;Human;Human Subject Research;Image;imaging capabilities;Imaging Device;imaging modality;imaging probe;imaging system;Imaging technology;improved;in vivo;in vivo imaging;instrument;Label;Laboratories;Laboratory Finding;Light;Lipids;Machine Learning;Maps;Measures;Medical;Medicine;Metabolic;Metabolism;Methods;Microscopic;Microscopy;Mitochondria;Modality;Molecular;Monitor;multimodality;Names;nanoparticle;Necrosis;Needles;new technology;novel;Optical Biopsy;optical imaging;Optics;Organelles;Organism;Pathologic;Pathology;Patients;Performance;Phase;Photoreceptors;point of care;Procedures;Process;Research Personnel;research study;Retina;Risk;Safety;Science;Sensitivity and Specificity;Signal Transduction;single molecule;Site;Slide;spatiotemporal;Spectrum Analysis;Stains;Structure;System;Systemic disease;Technology;technology development;Thick;Time;Tissue Expansion;Tissue imaging;Tissue Stains;Tissues;translational potential;uptake;Variant;Visualization

PROJECT_TITLE: Quantitative in-vivo and clinical imaging (Boppart)


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: ANASTASIO, MARK A (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Automobile Driving;Biological;biomarker discovery;Biophotonics;cellular imaging;Clinical;Collaborations;computerized tools;Computing Methodologies;Confocal Microscopy;Coupled;Data;data acquisition;Data Set;deep learning;design;Documentation;Equilibrium;fluorescence imaging;Goals;Image;Image Analysis;Image Enhancement;image reconstruction;image translation;imaging biomarker;imaging modality;imaging science;Imaging technology;improved;innovation;Interference Microscopy;Label;Lasers;Learning;Machine Learning;machine learning method;Maps;Measurement;Measures;Methods;microscopic imaging;Microscopy;Modeling;multimodality;Neurosciences;novel;open source;Optics;Output;Performance;Phase;Physics;reconstruction;Refractive Indices;Research;Resolution;Scanning;Semantics;Source;Source Code;Specificity;Stains;superresolution imaging;supervised learning;Supervision;System;Technology;technology research and development;Three-Dimensional Image;Three-Dimensional Imaging;tomography;Training;training data;Translations;Width;Work

PROJECT_TITLE: Computational imaging and intelligent specificity (Anastasio)


PHR: PROJECT NARRATIVE Age-related hearing loss (ARHL) is one of the most common degenerative diseases in the elderly. This project aims to determine the physiological and morphological changes of the cochlear nucleus during aging and to elucidate the neural mechanisms of ARHL.

PI_NAMEs: XIE, RUILI  (contact)

PROJECT_TERMS: 3-Dimensional;Ablation;Acoustic Nerve;Acute;Affect;Age;age group;age related;age related changes;Aging;Auditory;auditory processing;Auditory system;calretinin;Cells;Cellular Morphology;Cochlea;Cochlear nucleus;Collaborations;Computer Models;confocal imaging;Confocal Microscopy;Data;Degenerative Disorder;Development;Elderly;Electrophysiology (science);Exhibits;experimental study;Face;functional decline;Gene Modified;Genes;Goals;Health;hearing impairment;Image;Immunofluorescence Immunologic;Immunohistochemistry;inhibitory neuron;insight;Knock-in;Knock-in Mouse;Label;life span;Link;Membrane;molecular marker;Morphology;Mus;neuromechanism;Neurons;Output;Perception;Peripheral;Pharmacogenetics;Physiological;Physiology;postsynaptic neurons;Potassium;Presbycusis;Property;Role;Scanning Electron Microscopy;sensory input;signal processing;Site;Slice;sound;Specificity;spiral ganglion;stellate cell;Structure;Synapses;Synaptic Transmission;Techniques;Testing;transmission process;voltage clamp;Whole-Cell Recordings

PROJECT_TITLE: Age-dependent plasticity of central auditory synapses


PROJECT_TITLE: CLIMB Center Technology


PHR: Project Narrative Age-related hearing loss (ARHL) is a complex degenerative disease characterized by hearing impairment. The overall goal in this project (P3) is to understand the age-dependent structural and molecular remodeling of central auditory synapses and central nerve axonal fibers, to provide novel insights into how aging influences structural plasticity throughout the auditory system and how connectivity with downstream brain areas are altered in aging.

PI_NAMEs: RUBIO-VALERO, MARIA-EULALIA  (contact)

PROJECT_TERMS: Acoustic Nerve;Affect;Age;age related;aged;Aging;aging auditory system;aging brain;aging related;Area;arm;Auditory;Auditory area;auditory pathway;auditory stimulus;Auditory system;Axon;Biological Markers;Brain;Brain Stem;CBA/CaJ Mouse;Central Nervous System;Cochlea;Cochlear nucleus;Code;Complex;Data;Degenerative Disorder;Demyelinations;Diameter;Environment;Equilibrium;Exhibits;experimental study;Fiber;Fluorescent Antibody Technique;Gene Modified;Glutamate Receptor;Goals;hearing impairment;Hearing problem;Hyperacusis;Impairment;Individual;information processing;innovation;insight;Joints;Molecular;Monitor;Motor Activity;Myelin;myelination;Nerve;Nerve Fibers;neural;neuronal excitability;Neurons;novel;Optics;Organelles;Outcome;Pathway interactions;Peripheral;Physiological;Physiology;postsynaptic;Presbycusis;presynaptic;Presynaptic Terminals;Process;Property;Public Health;Pupil;Pyramidal Tracts;Research Personnel;Sensory;Signal Transduction;Site;sound;Sound Localization;Speech;stem;Structure;Sum;Synapses;Synaptic Transmission;System;Testing;Tinnitus;transmission process

PROJECT_TITLE: Alterations and mechanisms of auditory information processing in the aging auditory pathway


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Palliative Care

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Patients with cancer and heart failure, which are the leading causes of death in the US, accounting for 40% of deaths annually, experience significant suffering. The limited palliative care workforce prevents patients with these illnesses and their family caregivers from receiving palliative care. Our community- based palliative care intervention will improve patient symptoms and quality of life; increase goals of care discussions; decrease caregiver anxiety and improve caregiver satisfaction; and decrease healthcare utilization and cost.

PI_NAMEs: GELFMAN, LAURA PILAR (contact)

PROGRAM_OFFICER_NAME: SEAY, JULIA SUSAN

PROJECT_TERMS: 2 arm randomized control trial;Accounting;Acute;Address;Advanced Malignant Neoplasm;Advanced Practice Nurse;Anxiety;anxiety reduction;arm;care costs;care delivery;care systems;Caregiver support;Caregivers;Caring;Categories;Cause of Death;Cessation of life;Chaplain;Clinical;Communication;Communities;community based care;community based service;Community Health Aides;Community Trial;Complex;cost;COVID-19;cultural competence;Data;Deterioration;Discipline;Disease;Disease Management;Drug Prescriptions;efficacy evaluation;Emergency department visit;end of life;Enrollment;Ensure;experience;Family Caregiver;functional decline;functional status;Future;Goals;Growth;Health Care Costs;health care service utilization;Health Personnel;Health system;Heart failure;hospice environment;Hospitalization;Hospitals;improved;Individual;innovation;Inpatients;Intervention;Karnofsky Performance Status;Length of Stay;Malignant Neoplasms;medical specialties;Medicare;member;Modeling;Nature;novel;Outcome;Palliative Care;participant enrollment;Patient Care;Patient Self-Report;Patient-Focused Outcomes;Patients;Pattern;Persons;Physicians;Population;population based;post-traumatic stress;post-traumatic symptoms;preference;prevent;primary outcome;prognostic;programs;psychosocial;Quality of life;Randomized;randomized trial;Recovery;Reporting;Resources;satisfaction;Service delivery model;Services;Single-Blind Study;Site;Social Workers;symptom management;symptomatic improvement;Symptoms;Time;Training

PROJECT_TITLE: TIER-PALLIATIVE CARE: A population-based care delivery model to match evolving patient needs and palliative care services for community-based patients with heart failure or cancer

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative The goals of the University of Miami’s Clinical and Translational Science Institute are to improve the health of our community, address health disparities, and promote health equity. The CTSI will accomplish these goals by developing solutions to improve the efficiency of our research enterprise. In so doing, we will ensure that new discoveries and best practices equitably benefit the health of all patients and communities. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

PI_NAMEs: CARRASQUILLO, OLVEEN  (contact);KOBETZ, ERIN N

PROGRAM_OFFICER_NAME: LEYVA, FRANCISCO

PROJECT_TERMS: Acceleration;Address;Adoption;Advocate;Area;Behavior Therapy;Biomedical Research;career development;Clinical;Clinical Research;Clinical Sciences;clinical translation;Collaborations;Communities;community advisory board;Community Health;community organizations;community partners;Complex;County;Cultural Diversity;Development;Devices;disorder risk;Disparity;Dissemination and Implementation;Education;effective therapy;Effectiveness;effectiveness evaluation;effectiveness research;Ensure;Equity;equity, diversity, and inclusion;ethnic minority;Ethnic Origin;experience;Federally Qualified Health Center;Florida;Future;Goals;Health;Health Benefit;health disparity;health equity;health equity promotion;Health Promotion;Healthcare Systems;Hispanic;Immigrant;implementation efforts;improved;Inequity;innovation;Interdisciplinary Study;International;Intervention;Knowledge acquisition;Language;Leadership;Medical;member;Mentors;Methods;metropolitan;Minority;Minority-Serving Institution;multidisciplinary;novel;Participant;Patients;Persons;Pharmaceutical Preparations;Population;Positioning Attribute;Procedures;Process;programs;Public Hospitals;Puerto Rico;Race;racial minority;recruit;Reporting;Research;Research Personnel;Research Project Grants;research study;Resources;response;Risk Factors;Safety;Science;Services;Shapes;skills;socioeconomic disadvantage;Stigmatization;successful intervention;System;Testing;tool;Training;Training Programs;Translational Research;translational scientist;Universities;Work

PROJECT_TITLE: Miami Clinical and Translational Science Institute


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Type 1 diabetes (T1D) starts with attack on pancreatic beta cells that produce insulin, but the events that initiate this attack remain unclear. Extracellular vesicles (EVs) play a role to signal between the pancreas and immune system, raising the possibility that they participate in T1D. Here, we will use human tissue to identify EVs from pancreatic beta-cells, their RNA content and how they signal to immune cells, yielding novel insights into the biology of T1D and identifying new blood markers to detect T1D at its earliest stage.

PI_NAMEs: DAS, SAUMYA  (contact);KULKARNI, ROHIT N.;SHAH, RAVI

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Address;Autoantigens;Autocrine Communication;Autoimmune;Autoimmune Diseases;Autoimmunity;B-Lymphocytes;Beta Cell;Bioinformatics;Biological Markers;Biological Models;Biology;Blood;Bone Marrow;Case/Control Studies;cell injury;Cell Line;Cell Physiology;Cells;Cellular biology;Characteristics;Child;Childhood;Circulation;Clinical;cohort;Communication;Communities;cytokine;Data;Data Set;Detection;Development;Diabetes Mellitus;diabetes pathogenesis;Discrimination;Disease;disease diagnostic;early detection biomarkers;Early Diagnosis;Event;extracellular vesicles;Funding;Genetic Transcription;glucose uptake;Goals;Health;Histology;Human;Human Cell Line;human tissue;Immune;immune activation;Immune response;Immune system;Immunologics;immunoregulation;In Vitro;in vivo;Individual;Inflammation;Inflammatory;Injury;insight;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;intercellular communication;islet;Islet Cell;Islets of Langerhans;Laboratories;lipid metabolism;Macrophage;Measures;Mediating;Mediator;Membrane;Membrane Potentials;Membrane Proteins;Metabolic Diseases;Metabolism;Methods;Mitochondria;Modeling;Molecular;monocyte;Morbidity - disease rate;mortality;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Natural Immunity;neutrophil;novel;Oxidative Stress;Pancreas;Pancreatic Injury;Pathogenesis;Pathologic;Patients;Peripheral;peripheral blood;Persons;Phase;Phenotype;Plasma;Population;pre-clinical;Predisposition;prevent;Process;Production;protein biomarkers;Proteins;Proteomics;Reporter;Research;response;Risk;RNA;RNA Databases;Role;Sentinel;Signal Transduction;single nucleus RNA-sequencing;Specificity;Stimulus;Stress;Structure of beta Cell of islet;Synapses;System;Techniques;Tissues;trafficking;Transcript;transcriptome sequencing;translational study;Translations;United States National Institutes of Health

PROJECT_TITLE: Characterization of beta-cell-specific extracellular vesicle cargo as functional biomarkers for type I DM disease


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_CITY: Pittsburgh

ORG_NAME: MAGEE-WOMEN'S RES INST AND FOUNDATION

ORG_STATE: PA

PHR: NARRATIVE This renewal of R25 AG043365-10 (responsive to PAR-20-317) for NIA’s “Advancing Diversity in Aging Research through Undergraduate Education (ADAR)” program, now re-entitled: “Frontiers in Alzheimer’s and Aging Research EXPERIENCES” (FrA2RE), requests support for five cohorts of ≥12 promising undergraduates annually who “…are eligible…if they are from economically, socially, culturally, or educationally disadvantaged backgrounds’. FrA2RE concentrates on Structured Research Experiences by matching under-represented minority Trainees with Expert Mentors, creating a Dyad investigating Alzheimer’s disease and Related Dementias (ADRD) and Aging along with essential mentoring to launch and sustain careers within NIA’s portfolio, and is well justified since while the ADRD and aging fields continue to grow swiftly, and there are still too few laboratories led by URM scientists and too few new URM trainees. In so doing, FrA2RE innovatively enhances and expands the biomedical research careers of the most promising scientists, while ensuring their investigations comply with NIH’s policy of ‘Inclusion of Women, Minorities, and Individuals Across the Lifespan,’ particularly NIA’s focus on improving the diagnoses, health, and well-being, among the elderly and those suffering from Alzheimer’s Dementia and Related Disorders and their caregivers, and biological, clinical, behavioral, social aspects of aging, as well as helping to rectify inequities and increasing diversity.

PI_NAMEs: SCHATTEN, GERALD  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Address;African American;Aging;aging mechanism;aluminum sulfate;Alzheimer's Disease;Alzheimer's disease related dementia;American;Behavioral;Biological;Biology of Aging;Biomedical Research;Black race;career;Career Choice;career development;Caregivers;Cellular biology;Clinical;cohort;Congresses;Creativeness;Diagnosis;disadvantaged background;Disease;Doctor of Philosophy;Educational Activities;Educational process of instructing;Educational workshop;educationally disadvantaged;Elderly;Eligibility Determination;Ensure;equity, diversity, and inclusion;Ethics;ethnic identity;ethnic minority;experience;Faculty;faculty mentor;frontier;Funding;Goals;hands on research;Health;Health Disparities Research;health disparity populations;Hispanic Americans;hispanic community;improved;Indigenous;indigenous community;Individual;Inequity;innovation;Institution;Investigation;Laboratories;Latinx;Learning;Legal;life span;Louisiana;men who have sex with men;Mentors;Metabolism;Methods;Minnesota;Minority;minority trainee;Monitor;Morehouse School of Medicine;Native Americans;next generation;older adult;Outcome;Participant;Personal Satisfaction;Policies;Positioning Attribute;professor;programs;racial minority;Recommendation;recruit;Research;Research Personnel;Research Training;responsible research conduct;Science;Scientist;skills;social;Societies;Structure;Students;symposium;Time;Training;Training and Education;tribal Nation;undergraduate education;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Universities;Woman

PROJECT_TITLE: Frontiers in Alzheimer's and Aging Research Experiences


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Mental Health;Neurosciences;Pediatric;Prevention

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIVERSITY TEACHERS COLLEGE

PHR: Project Narrative This Pathway to Independence award seeks to train the applicant to establish an independent program of research that examines how stress impacts neurocognitive development and how changes in neurocognitive develop may confer risk for later socioemotional and neurocognitive functioning in a multicultural framework. The proposed research investigates how maternal and child stress alters brain activity across infancy and early childhood and how such alterations predict neurocognitive and socioemotional functioning. Elucidating the direct influence of chronic physiological stress on alterations in brain development and the functional significance of such alterations provides important insights for early identification and intervention of future long-term cognitive and socioemotional outcomes.

PI_NAMEs: TROLLER-RENFREE, SONYA VIOLET (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: 1 year old;3 year old;4 year old;Age Months;Award;behavior measurement;behavior prediction;Biological Markers;Brain;career;Child;Chronic;Chronic stress;Cognitive;cognitive neuroscience;Data;Development;Developmental Delay Disorders;Disease;early childhood;Early identification;Early Intervention;Electroencephalography;Emotional;emotional functioning;Environment;ethnic diversity;Exposure to;Foundations;Frequencies;Future;Goals;Hair;Hydrocortisone;Incidence;indexing;Individual Differences;infancy;Infant;Inflammation;insight;interdisciplinary approach;interest;Intervention;invention;Investigation;Laboratories;Laboratory Research;Life;Link;longitudinal, prospective study;maternal stress;Measurement;Measures;Mental Health;Methodology;Methods;Mothers;neural;Neurocognition;Neurocognitive;neurodevelopment;neuromechanism;novel;Outcome;Output;Parents;Participant;Pathway interactions;Pattern;perceived stress;Phase;Physiological;Play;Population Heterogeneity;Pregnancy;prenatal;prenatal exposure;prenatal influence;programs;prospective;Protocols documentation;racial diversity;recruit;Reporting;Research;Research Project Grants;Rest;Risk;Risk Marker;Role;Sampling;School-Age Population;Schools;skills;Stress;Testing;theories;Time;Training;Visit;visual tracking;Work

PROJECT_TITLE: Longitudinal investigation of the relations among stress, brain activity, neurocognitive skill, and socioemotional functioning during infancy


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Physical Rehabilitation;Prevention;Rehabilitation

ORG_DEPT: SURGERY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Rehabilitative care can play a major role in preventative care for older adults, targeting the prevention of functional decline and disability. This is known as prehabilitative care and the applicant is one of the few experts in this important area of patient-oriented research. This proposal is renewing support for him to serve as a mentor for trainees from diverse backgrounds wishing to advance their careers through a focus on geriatric rehabilitation research.

PI_NAMEs: BEAN, JONATHAN F (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Academy;Achievement;Address;Aging;American;Appointment;Archives;Area;Award;Biomechanics;Biometry;Boston;Capsicum;care seeking;career;career development;Caring;catalyst;Center for Translational Science Activities;Clinical;Clinical Assessment Tool;clinical center;Clinical Sciences;Clinical Trials;cognitive neuroscience;Collaborations;Conduct Clinical Trials;Consultations;Data Analyses;Development;disability risk;Discipline of Nursing;Doctor of Philosophy;Education;education research;Elderly;Elements;Environment;Epidemiology;Exercise Physiology;experience;Exposure to;Faculty;falls;Feedback;Foundations;functional decline;functional disability;Funding;Gait speed;Generations;Geriatrics;Grant;Habilitation;Impairment;implementation research;Individual;Interdisciplinary Study;interest;Joints;K-Series Research Career Programs;Knowledge;Laboratories;Lead;Leadership;Longitudinal cohort study;medical schools;Medical Students;member;Mentors;mid-career faculty;Mobility decline;Mobility disability;Modeling;modifiable risk;Morbidity - disease rate;mortality;Neurosciences;New England;older adult;Outcome;patient oriented research;Physiatrist;Physical Function;Physical Medicine;Physical Rehabilitation;Physical therapy;Play;Prevention;Preventive care;Privatization;Process;professor;programs;Publications;Randomized, Controlled Trials;rehabilitation research;rehabilitation science;Rehabilitation therapy;rehabilitative care;Research;Research Project Grants;Research Training;Resources;responsible research conduct;Risk Factors;Role;Scientist;Senior Scientist;Societies;Time;Training;Training Programs;Translational Research;United States National Institutes of Health;Work

PROJECT_TITLE: A Research Mentoring Program in Geriatric Rehabilitative Care

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: American Indian or Alaska Native;Clinical Research;Dissemination and Implementation Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Program Director/Principal Investigator (Last, First, Middle): Belone, Lorenda Project Narrative This study will strengthen dissemination and implementation (D&I) science by testing the implementation of our indigenous focused Family Listening Program (FLP), which is a culturally transformed intervention through the application of a community-based participatory research (CBPR) approach. In this new study we introduce an innovative process called CBPR Culture-Centered System which will be integrated with the Interactive Systems Framework (D&I structures and functions to bridge science & practice) for an examination of the uptake, cultural acceptance, and sustainability of evidence-based strategies moved into practice with three new southwest tribal communities. This grant will continue its long-term CBPR partnership with three southwest tribal partners which will provide a solid foundation for collaborating on the synthesis and translation of the following tools that will facilitate three new southwest tribal partners to adapt their own FLP curriculum and evaluation measures into their own distinct cultural knowledge, histories, values, and practices for implementation: a) Quality Implementation Tool; b) CAB Development Guide; c) Culture- Centered Coaching Guide; d) Digital Story Modules; and e) Culture-Centered FLP Toolkit.

PI_NAMEs: BELONE, LORENDA  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Adoption;American Indian community;Anxiety;Apache;Child;child depression;Collaborations;college;Communities;Community Actions;community advisory board;community based participatory research;community engagement;Coping Skills;Data;Data Aggregation;Development;digital;Dissemination and Implementation;dissemination science;Education;Educational Curriculum;Effectiveness;effectiveness testing;Elderly;Equity;Evaluation;evidence base;Failure;Family;Foundations;Future;Goals;Grant;Image;implementation context;implementation science;implementation strategy;implementation tool;implementation/effectiveness;improved;Indigenous;innovation;instrument;Interactive Systems Framework;intergenerational;Intervention;intervention program;Knowledge;knowledge translation;Lead;Measures;Mescalero;Modeling;National Institute of Drug Abuse;Navajo;New Mexico;novel;Observational Study;Outcome;Parents;peer;Population Heterogeneity;Prevention program;Principal Investigator;Process;Process Assessment;Program Evaluation;programs;protective factors;Pueblo Race;Recording of previous events;Research;Research Design;Risk Factors;Risk Reduction;Science;Solid;Structure;substance abuse prevention;Substance abuse problem;substance use;success;Support System;Surveys;symposium;System;Testing;tool;Training;Translating;Translations;tribal community;tribal member;Tribes;underserved community;Universities;uptake;Voice;Work

PROJECT_TITLE: Family Listening Program (FLP) CBPR Culturally-Centered Implementation Project

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-F(51)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

PHR: Project Narrative These experiments will provide insight into processes that contribute to cognitive decline with aging and Alzheimer’s disease. I will look at how neurons and their circuits change with age and try to determine which features are harmful and which features are coincidental. These data will help understand what form of the protein tau, a pathological hallmark of Alzheimer’s disease, should be targeted by clinical trials to treat cognitive decline in Alzheimer’s disease.

PI_NAMEs: ZWANG, THEODORE JOSEPH (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Adult;Affect;Age;Age of Onset;age related;age related changes;age related decline;Age-associated memory impairment;aged;Aging;aging and technology;aging brain;aging hippocampus;aging population;aging process;aging related;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;American;Animal Model;Behavioral;behavioral study;Biological Models;Biotechnology;Brain;Brain region;career;Cells;Characteristics;Chronic;Clinical;Clinical Trials;Cognition;Communication;Communities;Data;Dementia;Disease Progression;Electronics;Electrophysiology (science);entorhinal cortex;excitatory neuron;experience;experimental study;Foreign Bodies;Foundations;Functional disorder;Goals;Heterogeneity;Hippocampus;Histology;Human;Immune;Impaired cognition;Impairment;Individual;Injectable;innovation;insight;Lead;Learning;Longitudinal Studies;Medial;Medical;Memory;Memory impairment;middle age;Modeling;Monitor;mouse model;Mus;neural circuit;Neurodegenerative Disorders;Neurofibrillary Tangles;neuron loss;neuronal circuitry;Neuronal Dysfunction;Neurons;normal aging;novel;old mice;Pathologic;pathological aging;Pathology;physical science;Population;prevent;Process;Research;Research Personnel;Resistance;Resolution;response;skills;spatial memory;spatiotemporal;Syringes;tau aggregation;tau mutation;tau Proteins;Techniques;Technology;Testing;Time;tool;Training;virtual reality;Work

PROJECT_TITLE: Tracking the onset of spatial memory deficits in aging and Alzheimers disease models with single neuron resolution electrophysiology


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Engineered T cell therapies for cancer have demonstrated remarkable clinical responses in some patients, but many fail to respond due to poor T cell function. Current approaches to enhance T cell function and/or mitigate dysfunction are limited in their effectiveness and durability, and therefore new approaches are needed to help engineered T cells stay in the fight against cancer. This project will develop a novel approach to fundamentally reprogram T cells with enhanced tumor killing function, thereby paving the way for more efficacious cancer therapeutics.

PI_NAMEs: WEBER, EVAN WILLIAM (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Aging;aging related;Antitumor Response;B lymphoid malignancy;Biology;cancer therapy;CAR T cell therapy;Cell Physiology;Cell Reprogramming;cell type;Cells;Cellular biology;chimeric antigen receptor T cells;chromatin remodeling;Clinical;design;Development;Disease;DNA;Effectiveness;engineered T cells;Engineering;epigenetic drug;Epigenetic Process;epigenome;exhaustion;fighting;fitness;Functional disorder;Gene Expression;Genes;Goals;Human;improved;Liquid substance;Malignant Neoplasms;Mediating;Methods;Modality;Molecular;novel;novel strategies;Pathway interactions;Patients;prevent;programs;Research;response;Solid Neoplasm;Specificity;T cell therapy;T-Lymphocyte;Technology;Therapeutic;tool;transcription factor;translational potential;tumor;Work

PROJECT_TITLE: Enhancing CAR T cell fitness using novel epigenetic reprogramming factors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-A (70)]


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Immunotherapy

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative  While T cells provide powerful protection against viral infections and tumors, many cancers evade immune surveillance, and T cell destruction of self-tissues can lead to severe autoimmune diseases. Methods to control T cell reactivity remain scarce. This project will develop small molecules that fine-tune the recognition of antigens by T cells as a new therapeutic approach for the treatment of cancer and autoimmune diseases.

PI_NAMEs: ZHANG, ZIYANG  (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Alleles;Ankylosing spondylitis;anti-cancer;Antigen Presentation;Antigens;Autoantigens;Autoimmune;Autoimmune Diseases;cancer therapy;Celiac Disease;Chemicals;disorder risk;driver mutation;Drug Hypersensitivity;drug-like compound;Foundations;Genetic study;Glues;high throughput screening;Histocompatibility Antigens Class II;HLA-B Antigens;HLA-DQ2;Immune response;Immune Tolerance;Immunologic Surveillance;Insulin-Dependent Diabetes Mellitus;Ligands;Major Histocompatibility Complex;Malignant Neoplasms;Mediating;Methods;Molecular;Monitor;mutant;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;Oncoproteins;Patients;Peptides;Pharmaceutical Preparations;Process;programs;protein complex;Proteins;Reaction;Research;small molecule;T-Cell Receptor;T-Lymphocyte;therapeutic target;Tissues;tumor;Tumor Antigens;Tumor Escape;Viral Proteins;Virus Diseases

PROJECT_TITLE: Direct chemical targeting of MHC proteins for the treatment of cancer and autoimmune diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-L (70)]


ADMINISTERING_IC: PS

IC_NAME: NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STD AND TB PREVENTION

ORG_CITY: WINSTON-SALEM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Narrative Hispanic/Latino gay, bisexual, and other men who have sex with men (HLMSM) are disproportionately affected by HIV, and medical mistrust is associated with these HIV disparities because mistrust may result in delayed or reduced use of needed HIV prevention and care services. Our community-academic partnership proposes a rigorous mixed-methods, community-based participatory research (CBPR) study to better understand the drivers of medical mistrust among Spanish-speaking, English-speaking, and bilingual HLMSM. We also propose to refine and test a multilevel intervention designed to address medical mistrust and increase the use of needed HIV prevention and care services among diverse HLMSM in Mecklenburg County, NC, one of the jurisdictions prioritized by the Ending the HIV Epidemic in the US initiative.

PI_NAMEs: RHODES, SCOTT D (contact)

PROJECT_TITLE: Exploring and Intervening on Multilevel Factors of Medical Mistrust among Hispanic/Latino Gay, Bisexual and Other Men Who Have Sex with Men (HLMSM) for HIV Prevention in a Priority Jurisdiction


ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Neuroinflammation is a major modifier of disease progression in neurodegenerative disease, yet we lack critical insight into its molecular origins. Recently, we unexpectedly discovered that the pathological proteins found in these conditions mimic the behavior of innate immune signals. Here, we propose to uncover the biophysical and molecular rules that dictate this mimicry to help us better understand the etiology of neuroinflammation in disease and aid us in devising new ways for therapeutic intervention.

PI_NAMEs: BOEYNAEMS, STEVEN  (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Age related pathologies;anti-microbial peptide;Antigens;arms race;Biology;Biophysics;Brain Diseases;Data;detection platform;Disease;disease model;Disease Progression;Electrostatics;Etiology;experience;extracellular;frontotemporal lobar dementia amyotrophic lateral sclerosis;Genetic;Gliosis;Human;Immune;Immune signaling;Immune system;immunogenicity;In Vitro;in vivo;in vivo Model;Infection;Inflammatory;Inflammatory Response;Innate Immune System;insight;Instinct;interdisciplinary approach;Literature;mimicry;Molecular;Molecular Mimicry;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;Neuroimmunomodulation;neuroinflammation;Neurons;neuropathology;Nucleic Acids;Onset of illness;pathogen;Pathologic;Pathology;Peptides;Physical condensation;pressure;Process;Proteins;Proteomics;receptor;response;Role;Shapes;Signal Transduction;Testing;Therapeutic;Therapeutic Intervention;Toll-like receptors;trafficking;Training

PROJECT_TITLE: Uncovering the role of extracellular condensates as triggers of neuroinflammation


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Infants represent one of the most vulnerable members of society and considerable resources are devoted to their healthy development, but we know surprisingly little about how their brains process social information from primary caregivers. This project is aimed at understanding the sensory encoding of maternal cues in the infant brain and its contribution to adult social behavior. This is relevant to the mission of the NIH due to its potential to reveal mechanisms underlying sensory neuron dysfunction underlying neurodevelopental disorders and sex biases in their manifestation.

PI_NAMEs: BAMBAH-MUKKU, DHANANJAY  (contact)

PROJECT_TERMS: Adult;Afferent Neurons;autism spectrum disorder;Back;Behavioral;Behavioral Paradigm;Birth;Brain;caregiving;Caring;cell type;Cues;Desire for food;Development;Disease;early life adversity;experience;experimental study;Functional disorder;Gene Expression;Genetic;Goals;Growth;Hour;Human;imprint;Infant;insight;Investigation;Life;Maps;maternal separation;member;Memory;Mission;Molecular;multisensory;Mus;Nervous System;neural;Neurodevelopmental Disorder;neuromechanism;Neuronal Dysfunction;Neurons;neuropsychiatric disorder;Odors;Phase;Positive Valence;postnatal;primary caregiver;Process;Prosencephalon;pup;Resolution;Resources;Role;Sensory;Sex Bias;sexual dimorphism;social;Social Behavior;social deficits;Social Development;Societies;Source;Technology;tool;transcriptomics;United States National Institutes of Health;Viral;Work

PROJECT_TITLE: The Multisensory Ontogeny of Social Behavior


NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative: While electrical current is the basis of biological signal transduction and fundamental to all life on this planet, the structural conformation of biological components under electrical stimulus remains elusive. This proposal will establish a novel technique, electrified cryo-EM, that will enable the first nanoscale studies of dynamic neuron activity during an action potential stimulated by an external electrical impulse. Insights from this program will have significant impact on informing next-generation neurostimulation treatments for neurological diseases.

PI_NAMEs: LI, YUZHANG  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Action Potentials;Award;Behavior;Biological;biological systems;Biology;Cells;Cryoelectron Microscopy;Development;Devices;Drug Delivery Systems;Electric Stimulation;Electroporation;Equilibrium;Freezing;Frequencies;Future;Goals;Health;Human;Imaging Techniques;in situ imaging;insight;Kinetics;Length;Life;Medical;Methodology;Molecular;Molecular Conformation;Molecular Structure;Muscle Contraction;nanometer resolution;nanoscale;Nervous System Disorder;neural circuit;Neural Inhibition;neuromechanism;Neurons;next generation;Nobel Prize;novel;novel strategies;Patients;Planets;preservation;programs;Proteins;Research;Resolution;response;Retinal blind spot;Sensory;Series;Signal Transduction;Stimulus;Structure;superresolution microscopy;Synapses;Synaptic Cleft;System;Techniques;therapeutic target;Time;tool;voltage gated channel;wound healing

PROJECT_TITLE: Electrified cryo-EM: a new tool to capture metastable neuron structures during an action potential


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Bioengineering;Data Science;Dental, Oral, and Craniofacial Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: 8. PROJECT NARRATIVE –––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––– Whereas scientists can now readily measure the DNA, RNA, and protein content within any biological sample, measuring the small molecules in that same sample has remained more challenging. This project aims to develop a suite of machine-learning tools that will allow us to more comprehensively measure both known and unknown small molecules in any biological sample by analyzing mass spectrometry data. The possibility of identifying unknown small molecules in high-throughput would increase the scope and efficiency of many publicly funded studies and open up new perspectives on the chemical world around us.

PI_NAMEs: SKINNIDER, MICHAEL ALEXANDER (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TERMS: Address;adduct;Architecture;Benchmarking;Biological;built environment;Cells;ChatGPT;Chemical Structure;Chemicals;Collaborations;Communities;Complex;Computational Biology;computational suite;Computer software;computerized tools;computing resources;Creativeness;dark matter;Darkness;Data;Data Analyses;Data Set;data standards;Databases;design;Development;Diet;Disease;DNA;Ecosystem;Educational process of instructing;Environment;Excision;experience;experimental study;Exposure to;Foundations;Funding;Genomics;Goals;graduate student;gut microbiota;High Performance Computing;Human;Human body;Individual;Infrastructure;Institution;Language;large language model;Learning;Life;Link;Machine Learning;Manuals;Mass Spectrum Analysis;Measures;Mentors;Mentorship;Metabolism;metabolome;metabolomics;Modeling;Morphologic artifacts;multidisciplinary;Natural Language Processing;novel;novel strategies;personalized medicine;Positioning Attribute;Principal Investigator;Productivity;professor;programs;Proteins;Publications;Recording of previous events;recruit;repository;Research;Resources;RNA;Sampling;Scientist;self supervised learning;Signal Transduction;small molecule;Structure;Students;Technical Expertise;Techniques;Technology;Time;tool;Training;training data;Universities;user-friendly;virtual;Vision;Work;Xenobiotics

PROJECT_TITLE: A machine-learning platform to illuminate the chemical dark matter in mass spectrometry-based metabolomics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-E (70)]