ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: PROJECT NARRATIVE The proposed research is relevant to the NIH’s mission and public health because it aims to determine the cellular, molecular and electrophysiological mechanisms of mechanical regulation of the sinoatrial node, the primary natural pacemaker of the heart. Our work will define how specialized cardiac cell membrane mechanosensitive domains and associated signaling molecules contribute to both physiological regulation of the sinoatrial node and its remodeling and dysfunction during chronically elevated mechanical overload in hypertension. The potential impact of this research is high because the mechanistic insights gained from it can serve as a foundation for developing innovative therapeutic strategies aimed at preventing sinus node dysfunction in hypertensive individuals.

PI_NAMEs: GLUKHOV, ALEXEY V (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Address;Anatomy;Autonomic nervous system;biochemical model;Biology;Blood Pressure;Bradycardia;Cardiac;Cardiac Output;Cardiac Volume;Caveolae;caveolin-3;Cell membrane;Cells;Cessation of life;Chronic;chronotropic;Complex;Computer Models;Coronary;Coupling;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;design;Development;Electrophysiology (science);Elements;Emotional;Environment;Exercise;Exhibits;Feedback;Female;Fluorescence Resonance Energy Transfer;Foundations;Functional disorder;Genes;Heart;Heart Atrium;heart dimension/size;Heart Diseases;Heart failure;heart function;Heart Rate;heart rhythm;Heart Valve Diseases;hemodynamics;Heterogeneity;Homeostasis;Hypertension;hypertensive;hypertensive heart disease;Image;imaging modality;Impairment;improved;in silico;in vivo;Individual;innovation;insight;intracardiac pressure;Investigation;Ion Channel;Knockout Mice;Knowledge;Link;Location;male;Measurement;mechanical load;Mechanics;Mediating;Metabolic;Mission;Modeling;Molecular;Mus;Muscle Cells;nano;nodal myocyte;novel;overexpression;Pacemakers;Paint;Pathology;Performance;Phenotype;Phosphorylation;Physiological;Play;population based;Positioning Attribute;pressure;prevent;preventive intervention;Procedures;Production;protein complex;Proteins;Public Health;Quality of life;Rattus;Regulation;Research;response;Role;sensor;Sex Differences;Sick Sinus Syndrome;Signal Transduction;Signaling Molecule;Sinoatrial Node;Sinus;spatiotemporal;stressor;Stretching;Structure;Study models;Syncope;Syndrome;Tachycardia;Testing;Therapeutic;translational approach;United States National Institutes of Health;Vascular blood supply;Venous;Ventricular Remodeling;voltage;Work

PROJECT_TITLE: Functional Microdomains in the Heart's Pacemaker: A New Dimension of Cardiac Remodeling

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: ES

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Emergency Care;Health Services;Prevention;Social Determinants of Health

ORG_CITY: TUCSON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE The U.S.-wide burden on emergency medical services (EMS) systems associated with environmental exposures remains unknown. In this study, we will utilize a national database of 911 calls, the National Emergency Medical Services Information System (NEMSIS), to test the hypothesis that short-term air pollution and temperature exposures are associated with EMS transports. We will also measure the impact of exposure misclassification on the risk estimates by leveraging recent advancements in exposure assessment tools (low- cost sensors and mobility data) and unique information in EMS data on event locations and times.

PI_NAMEs: LIM, CHRIS CHAEHA (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: 911 call;Address;Adult;Air Pollution;Architecture;Area;Assessment tool;Biometry;built environment;Cardiovascular system;Caring;Censuses;Characteristics;Cities;climate change;Communities;Complex;cost;COVID-19;COVID-19 pandemic;Data;Data Set;Databases;demographics;density;Dimensions;Elderly;Emergency medical service;Emergency Medicine;Environmental Exposure;Environmental Health;Environmental Impact;Epidemiology;Event;experience;Exposure to;fine particles;Geographic Information Systems;Geographic Locations;Geography;Health;health care service organization;health data;Health system;Hour;Individual;Information Systems;Infrastructure;Injury;insight;Investigation;Link;Location;Measures;Methods;Modeling;Modification;Monitor;Neighborhoods;Nitrogen Dioxide;Outcome;Ozone;Participant;Patients;Pattern;Policy Maker;Population;promote resilience;Public Health;Research Personnel;residence;respiratory;response;Risk;Risk Estimate;sensor;service providers;sociodemographics;spatiotemporal;Stress;System;Temperature;Testing;Time;urban area;Work

PROJECT_TITLE: Short-term environmental exposures and emergency medical service activation in the U.S

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE Rapidly evolving antibiotic resistance requires a matching effort to develop novel and effective antimicrobial agents. Particularly, infections caused by emerging carbapenem-resistant Enterobacterales and carbapenem- resistant Acinetobacter baumannii, which are difficult to treat, have been recognized as an urgent threat. The goal of the proposed project is to study preexisting cefiderocol resistance and heteroresistance without prior cefiderocol exposure and the evolution of cefiderocol resistance after cefiderocol exposure in vitro and in patients.

PI_NAMEs: HUANG, EN  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acinetobacter baumannii;anti-microbial drug;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;antimicrobial;Bacteria;Bacterial Infections;beta-Lactamase;carbapenem resistance;carbapenem resistant Enterobacterales;Carbapenem-resistant Acinetobacter;carbapenemase;Cells;Cephalosporins;Clinical;clinically relevant;Comparative Genomic Analysis;comparative genomics;cost;Detection;Development;DNA Sequence Alteration;drug resistant pathogen;economic cost;Enterobacter cloacae;Escherichia coli;Evolution;Exhibits;experimental study;fitness;gene complementation;Gene Deletion;Genes;Genetic Transcription;genome-wide;Goals;Gram-Negative Bacteria;Health;Heterogeneity;In Vitro;individual patient;Infection;insight;Intermediate resistance;Investigation;Klebsiella pneumoniae;Knowledge;Masks;Mediating;Medical;Membrane;Molecular;Monitor;Morbidity - disease rate;mortality;Multi-Drug Resistance;mutant;Mutation;novel;pathogen;Patients;Population;Predisposition;preservation;Prevalence Study;prevent;Process;Public Health;real world application;Reporting;research study;Resistance;Resistance development;resistance gene;resistance mechanism;resistant strain;response;Serial Passage;Serine;siderophore receptors;Siderophores;single-cell RNA sequencing;Source;surveillance study;transcriptome sequencing;transposon sequencing;Treatment Failure;Treatment outcome;Virulence;whole genome

PROJECT_TITLE: Mechanisms of cefiderocol nonsusceptibility and resistance evolution in carbapenem-resistant pathogens

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AIRT-J (01)]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease

ORG_CITY: SALT LAKE CITY

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Veno-arterial extracorporeal membrane oxygenation (VA ECMO) may enable survival of patients with severe acute cardiogenic shock (CS), which kills 80,000 Americans each year, but may also cause harm to the failing heart. A clinical management change of unloading/decompressing the heart during VA ECMO for CS may improve survival for these patients. Understanding the physiologic effects of unloading on the heart is an important step towards conducting clinical trials of unloading during VA ECMO for CS and improving patient outcomes during ECMO and CS.

PI_NAMEs: TONNA, JOSEPH EDWARD (contact)

PROGRAM_OFFICER_NAME: SIDDIQUI, AYESHA SAEED

PROJECT_TERMS: Acute;Acute myocardial infarction;Affect;American;Aorta;arm;Award;Biological Markers;biomarker validation;Blood;Blood flow;Cardiac;Cardiac Output;Cardiogenic Shock;Cardiopulmonary;Cardiovascular Physiology;Cardiovascular system;Chronic;Clinical;Clinical Management;Clinical Trials;Complication;Conduct Clinical Trials;Critical Care;cytokine;Data;Death Rate;design;Devices;Diameter;Diastolic blood pressure;Echocardiography;EFRAC;Emergency Medicine;Enrollment;Equilibrium;Etiology;Extracorporeal Membrane Oxygenation;Failure;Future;Goals;Heart;Heart Ventricle;hemodynamics;Hour;improved;Injury;innovation;Intervention;Intra-Aortic Balloon Pumping;K-Series Research Career Programs;Knowledge;Left;Left ventricular structure;long term recovery;Lung;Measures;mechanical circulatory support;Mechanics;Mediating;Methods;mid-career faculty;Morbidity - disease rate;mortality;Myocardial;myocardial injury;National Heart, Lung, and Blood Institute;novel;novel strategies;Observational Study;Outcome;participant enrollment;Pathway interactions;Patient-Focused Outcomes;Patients;Perfusion;Phase;Physiological;Physiology;predictive marker;primary outcome;Pulmonary Capillary Wedge Pressure;Pulse Pressure;Randomized;Recovery;Refractory;Research Personnel;Sample Size;secondary outcome;Selection Bias;standard of care;Stretching;Target Populations;Testing;Training;trial design;Troponin;United States National Institutes of Health;Universities;Utah;Validation;Ventricular;Ventricular Remodeling;Weaning;Work

PROJECT_TITLE: Physiology of Unloading VA ECMO Trial

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-R (02)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Disease;Prevention

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_STATE: WI

PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE STATEMENT  The broad, long-term objective of our research is to improve the health of the ~1.5 billion people in the world with chronic liver disease that can progress to liver failure, liver cancer, and liver-related death. We seek to develop and validate non-invasive methods of assessing the activity of chronic liver disease. These methods will reduce the need for biopsy, permit earlier diagnosis, and facilitate more effective treatment, thereby pre- venting the serious long-term complications of chronic liver disease.

PI_NAMEs: PIRASTEH, ALI  (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Address;Affect;Alcoholic Liver Diseases;Biological;Biological Markers;biomarker development;Biopsy;Breathing;Caring;Cell surface;Cessation of life;chronic liver disease;Cicatrix;Cirrhosis;Clinic;Clinical;Clinical assessments;clinical implementation;Clinical Research;Clinical Trials;Collagen;Deposition;Development;Differentiation Antigens;drug development;drug discovery;Early Diagnosis;effective therapy;elastography;Evaluation;Family suidae;fibroblast-activating factor;fibrogenesis;Fibrosis;Foundations;Future;Goals;Health;Hepatic Fibrogenesis;Hepatic Stellate Cell;hepatocellular injury;Hepatocyte;Hepatology;Hepatotoxicity;hepatotoxin;Histologic;Histology;Human;Image;imaging biomarker;Immunohistochemistry;improved;in vivo;Inflammation;inhibitor;innovation;Knowledge;Liver;Liver diseases;Liver Failure;Liver Fibrosis;liver imaging;liver inflammation;liver injury;liver stiffness;Magnetic Resonance Elastography;Magnetic Resonance Imaging;Malignant neoplasm of liver;Measurement;Measures;Methods;Miniature Swine;Modeling;Monitor;Motion;multidisciplinary;Mus;Non-Invasive Detection;novel strategies;Outcome;Pain;Pathologic Processes;Patients;Persons;Pharmaceutical Preparations;porcine model;Positioning Attribute;Positron-Emission Tomography;pre-clinical;pre-clinical assessment;preclinical evaluation;prevent;prognostic;protein expression;public health relevance;Qualifying;Radiolabeled;radiotracer;Research;Risk;Sampling;Serology;Serum Markers;specific biomarkers;Specimen;Standardization;Techniques;Time;Tissues;Transplantation;treatment response;uptake;Validation;Wisconsin

PROJECT_TITLE: Development of FAPI PET as a Non-invasive Biomarker of Liver Fibrogenesis

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Orphan Drug;Ovarian Cancer;Precision Medicine;Rare Diseases;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE We will develop a paired imaging/tissue biomarker of sensitivity to PARP inhibitors (PARPi) that can be used for patient selection, visualization of drug-target engagement, and potentially long-term dose modulation. In breast cancer, where PARPi are currently used largely in the setting of metastatic disease, the ability to predict response would also provide a critically needed tool to stratify patients for clinical trials testing neoadjuvant PARPi therapy/therapy combinations. If successful, this research could lead to a new way to functionally characterize PARP-1 expressing cancer, guide targeted therapy, and assess therapeutic response and resistance.

PI_NAMEs: MCDONALD, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: Adjuvant;Aftercare;aggressive breast cancer;analog;Animal Disease Models;Autoradiography;Binding;Biological Assay;Biological Markers;Biopsy;brca gene;burden of illness;Cancer cell line;Cell Fractionation;Cell Nucleus;Clinical;clinical practice;Clinical Trials;cohort;Combination Drug Therapy;Combined Modality Therapy;companion diagnostics;Companions;comparative efficacy;Complement;Data;density;detection limit;Development;Disease;Dose;Drug Monitoring;Drug Targeting;Drug toxicity;Enrollment;Estrogen receptor positive;Estrogen Receptors;Failure;Freezing;Functional Imaging;Genomics;Goals;Human;Image;imaging agent;imaging probe;Immunohistochemistry;In Vitro;in vivo;in vivo imaging;inhibitor therapy;innovation;Investigation;Lesion;Life;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Measures;Methodology;Mus;Neoadjuvant Therapy;neoplastic cell;Nuclear;Outcome;Parents;patient derived xenograft model;Patient imaging;Patient Selection;patient stratification;Patients;PET/CT scan;Pharmacologic Substance;Poly(ADP-ribose) Polymerase Inhibitor;Population;Positron-Emission Tomography;pre-clinical;precision medicine;predicting response;predictive marker;predictive modeling;predictive test;Predictive Value;Predictive Value of Tests;Predisposition;Production;prospective;radioligand;radiotracer;Reference Standards;Research;Resistance;response;Role;Sampling;Scanning;Selection for Treatments;Specificity;standard measure;Standardization;targeted treatment;Testing;Therapeutic;therapy resistant;Time;tissue biomarkers;Tissue imaging;Tissues;tool;Tracer;Treatment Efficacy;treatment response;triple-negative invasive breast carcinoma;tumor;tumor progression;Tumor Volume;uptake;Visualization;Western Blotting;Xenograft procedure

PROJECT_TITLE: Developing PARP-1 PET with companion tissue assay as a precision tool to guide PARPi therapy

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Genetics;Human Genome;Macular Degeneration;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: Project Narrative Our scientific premise is that maladaptive changes in DNA modifications and chromatin accessibility accumulate in the retinal pigmented epithelium (RPE) with aging leading to RPE dysfunction and contributing to age-related macular degeneration (AMD) pathogenesis. Whether RPE epigenetic aging is exacerbated by poor diet and can be slowed by ketogenic diet will also be tested. These studies will provide fundamental knowledge to the field and new biological/functional insights into RPE aging as well as identify RPE-specific epigenomic targets for manipulation to maintain RPE function with aging and prevent AMD pathogenesis.

PI_NAMEs: CHUCAIR-ELLIOTT, ANA JULIA;FREEMAN, WILLARD M (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Address;advanced disease;Age;age acceleration;age related;age related changes;Age related macular degeneration;Aging;Alleles;Animals;ATAC-seq;Atrophic;base;Bioinformatics;Biological;bisulfite sequencing;Blindness;Caloric Restriction;Carbohydrates;cell type;Chromatin;Clinical;Clinical Research;Consumption;Couples;Cytosine;Data;Data Science;design;Diet;dietary;Dietary Carbohydrates;dietary control;Dietary Intervention;dietary manipulation;Dietary Practices;Disease Pathway;disorder risk;DNA;DNA Methylation;DNA Modification Process;Electroretinography;epigenetic aging;epigenetic clock;Epigenetic Process;epigenome;epigenome editing;epigenomics;experimental group;Fatty acid glycerol esters;Female;Functional disorder;Future;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic;Genome;genome-wide;genomic locus;Genomic Segment;Genomics;Glycemic Index;Goals;human old age (65+);Impairment;inducible Cre;insight;Intervention;Intervention Studies;ketogenic diet;ketogentic;Knockout Mice;Knowledge;late life;Length;life span;Machine Learning;male;Maps;Measurement;Mediating;Metabolic;Methods;Methylation;middle age;Modeling;Modification;mouse model;Mus;Neurodegenerative Disorders;Nonexudative age-related macular degeneration;normal aging;novel;Nucleic Acid Regulatory Sequences;Nucleic Acids;Onset of illness;Oxidative Stress;Pathogenesis;Pathogenicity;pathological aging;Pathway interactions;Patients;Pattern;Phenotype;Photoreceptors;Play;prevent;prospective;recombinase;Regulation;Reporting;Research;Resolution;Resources;response;Retina;Risk;Risk Factors;RNA;Role;sex;Signal Transduction;single-cell RNA sequencing;Site;Speed;Stress;Structure of retinal pigment epithelium;Syndrome;Tamoxifen;Testing;Therapeutic;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Transgenic Organisms;translatome;Unhealthy Diet;Vision;Vision research;Visual Acuity;western diet;whole genome

PROJECT_TITLE: Retinal Pigmented Epithelium Epigenome Dysregulation With Aging and Modulation by Diet

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed study will experimentally evaluate the ability of ultra-processed foods to activate reward, attention, and memory regions that influence eating behavior compared to minimally-processed foods, investigate the relative role of the higher caloric content versus the flavor enhancers of ultra-processed foods to engage these regions using a 2 x 2 experimental design, and test whether ultra-processed foods are more effective in promoting the incentive salience of food cues than minimally-processed foods, which is important because elevated reward region response to food cues predicts future weight gain. It will also test whether individuals who show the greatest activation in reward, attention, and memory regions in response to ultra- processed foods and stronger food reward cue learning are at risk for greater ad lib intake of ultra-processed foods and future body fat gain. This study should advance knowledge regarding the mechanisms through which ultra-processed foods contribute to overeating and guide the design of more effective obesity prevention programs and treatments.

PI_NAMEs: STICE, ERIC M (contact)

PROGRAM_OFFICER_NAME: WOO, THERESA TESLOVICH

PROJECT_TERMS: Attention;Automobile Driving;Behavioral;Body fat;Body Weight decreased;Brain;Brain imaging;Brain region;Calories;Cessation of life;Chocolate;common treatment;Consumption;Corpus striatum structure;Cues;Data;density;design;Diet;dietary;Eating;Eating Behavior;efficacy evaluation;energy density;Energy Intake;Enhancers;excessive weight gain;Experimental Designs;experimental study;Fatty acid glycerol esters;Fiber;Fingerprint;Food;Formulation;Fostering;Future;Human;Hyperphagia;Image;imaging study;improved;incentive salience;Incentives;Individual;Industrialization;Intake;Knowledge;Learning;life span;Macronutrients Nutrition;Medial;Memory;memory retrieval;mortality;neural;Nucleus Accumbens;Nutrient;Obesity;obesity prevention;obesity treatment;overweight adults;Participant;Prefrontal Cortex;premature;Prevention program;Process;Psychological reinforcement;response;reward circuitry;reward processing;Rewards;Risk;Role;Signal Transduction;Sodium;Source;sugar;Taste Perception;Testing;theories;Weight;Weight Gain;weight loss intervention;World Health Organization

PROJECT_TITLE: Effects of Processed Foods on Brain Reward Circuitry and Food Cue Learning

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Mental Health

ORG_CITY: Columbus

ORG_DEPT: PSYCHIATRY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE We posit that a barrier to the treatment of T2D diabetes relates to broad difficulties with emotional regulation (ER) that are not diagnosis specific but lead to Diabetes Distress (DD) and difficulty in coping with medical regimens, and other aspects of diabetes self-care, when confronted with the psychosocial stressors associated with having diabetes. Recent work suggests an important relationship between emotional regulation, elevated DD scores and elevated A1c levels – characteristics that may impact up to 25% of all those with T2D; preliminary data using emotion-focused interventions suggest that elevated DD and A1c levels can be reduced in PWD with T2D. In this project we propose to adapt our emotion-focused behavioral intervention (EFBI) from a one-to-one intervention (I-EFBI) to a group intervention (G-EFBI) and to conduct a pilot RCT study to determine if G-EFBI is a feasible, acceptable and, possibly, efficacious intervention compared to an “Attentional Control” intervention in PWD with T2D and elevated DD and A1c levels.

PI_NAMEs: COCCARO, EMIL FRANK (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: Address;Adult;Attention;attentional control;barrier to care;Behavior Therapy;Caring;Cause of Death;Characteristics;comparison intervention;Complications of Diabetes Mellitus;Control Groups;coping;cost;Data;Development;diabetes distress;Diabetes Mellitus;diabetes self-management;effectiveness/implementation trial;efficacious intervention;efficacious treatment;Eligibility Determination;emotion regulation;Emotional;emotional distress;Emotions;Enrollment;experience;Foundations;Glycosylated Hemoglobin;Glycosylated hemoglobin A;Goals;group intervention;Individual;Insulin-Dependent Diabetes Mellitus;Intervention;Lead;Measures;Medical;Modification;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Patients;Persons;Pilot Projects;Prevalence;psychosocial stressors;Public Health;Recommendation;Regimen;Reporting;response;retention rate;Risk;skills;Stress;Testing;Therapeutic;Work

PROJECT_TITLE: Development of a Group Emotion-Focused Behavioral Intervention for Diabetes Distress and Glycemic Management in Patients with T2D.

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Disability Research;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: PROJECT NARRATIVE Genetic mutations in the sodium channel gene SCN8A cause a severe, early-onset seizure disorder along with significant motor impairment. We have generated a unique new mouse model that is the first to exhibit the motor impairment characteristic of SCN8A epilepsy. This proposal seeks to investigate the pathophysiologic mechanisms underlying motor dysfunction to provide new information that will help guide development of treatments for this debilitating disorder.

PI_NAMEs: WAGNON, JACY LEE (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: Action Potentials;Address;Affect;Age;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Architecture;Ataxia;Axon;Behavior assessment;behavior test;Biophysics;Brain;Cessation of life;Characteristics;Clinical;comorbidity;Data;Development;Developmental Delay Disorders;Disease;DNA Sequence Alteration;Dyskinetic syndrome;Dystonia;early onset;early onset disorder;Electrophysiology (science);Epilepsy;epileptic encephalopathies;excitatory neuron;Exhibits;experimental study;Functional disorder;gain of function;Genes;Genetic;genetic variant;Heterozygote;Histology;Impaired cognition;Impairment;improved;Incidence;Individual;infancy;Injections;insight;Intellectual functioning disability;Maintenance;Measures;Modeling;Morphology;Motor;motor control;motor disorder;motor impairment;Motor Neurons;Motor Seizures;mouse model;Movement Disorders;Mus;Muscle;Muscle Fibers;Muscle hypotonia;Muscle Weakness;Mutation;nerve supply;neuromuscular;Neuromuscular Junction;neuron loss;neuronal excitability;Neurons;novel;novel therapeutic intervention;Pathogenesis;Pathology;Patients;pharmacologic;Phenotype;Population;postnatal;premature;prevent;Prosencephalon;Quality of life;Recurrence;Reporting;Resistance;Risk;Role;SCN8A gene;Seizures;severe intellectual disability;Sodium Channel;Spinal;Spinal Cord;Spinal Muscular Atrophy;Structure;Tamoxifen;Testing;Therapeutic;therapy development;Time;Variant;voltage;Work

PROJECT_TITLE: Understanding the role of SCN8A in developmental and epileptic encephalopathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CNNT-N (90)]


ADMINISTERING_IC: LM

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Machine Learning and Artificial Intelligence;Multiple Sclerosis;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: CHAMPAIGN

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: PROJECT NARRATIVE About 51.8% (129 million) of American adults had at least one chronic condition, which is attributed to the total direct and indirect cost of $3.7 trillion and demands imperatively patients to self-manage their health across their lifespans. However, most existing self-management interventions and apps do not enable users with chronic health conditions, such as multiple sclerosis (MS), to actively utilize resources, solve problems, develop self- efficacy, and empower decision-making. We will develop and validate MyMSMentor for people with MS, which will be generalizable to other chronic conditions and devices, to maximize their lifelong capacity of self- management.

PI_NAMEs: CHIN, JESSIE ;CHIU, CHUNG-YI  (contact);ZHAI, CHENGXIANG

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: acceptability and feasibility;adaptive intervention;Address;Adopted;Adoption;Adult;Algorithms;American;Arthritis;Artificial Intelligence;artificial intelligence algorithm;Awareness;behavior change;Big Data;biomedical informatics;Cellular Phone;Chronic;Clinical;Cognitive Science;Collaborations;comorbidity;cost;Data;Data Science;Decision Making;design;Devices;Diabetes Mellitus;Dimensions;Direct Costs;Economic Burden;empowerment;experience;Face;Facilities and Administrative Costs;Feedback;Focus Groups;Frequencies;Generations;Goals;Health;Health behavior;Health Care Costs;health care service;health management;Health Personnel;Healthcare;Individual;information model;innovation;intelligent agent;interest;Intervention;Interview;Life;life span;machine learning model;Maintenance;Measurement;Measures;Methods;mHealth;Mobile Health Application;Modeling;Motivation;Multiple Sclerosis;multiple sclerosis patient;Neurologic;novel;Participant;patient oriented;Patient Outcomes Assessments;Patients;Pattern;Persons;Phase;preference;Problem Solving;Process;prototype;Recommendation;recruit;Relapsing-Remitting Multiple Sclerosis;Research;Resources;Searching Behavior;Self Care;Self Efficacy;Self Management;skills;social;Structure;Symptoms;System;Tablets;Techniques;Technology;theories;Time;tutorial review;Update;usability

PROJECT_TITLE: Building and Validating Lifelong Self-Management Capacity with Advanced AI: MyMSMentor

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biomedical Imaging;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Lung;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Pulmonary Fibrosis

ORG_CITY: INDIANAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Many patients with serious COVID infection continue to have lung problems long after the acute infection has resolved. This may be due to persistence of SARS-CoV-2 products in the lung stimulating unwanted lung inflammation and immune responses. Our study will examine in detail the lung immune and inflammatory environment in patients with post COVID chronic lung disease with the goals of (1) linking lung disease to specific types of immune and inflammatory responses, (2) determining whether this is due to persistent viral products in the lung, and (3) assessing protective versus potentially harmful immune responses in the pathogenesis of post- COVID lung disease. OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page Continuation Format Page

PI_NAMEs: TWIGG, HOMER L (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: 2019-nCoV;Acute;acute COVID-19;acute infection;Address;Alveolar;Antibodies;Automobile Driving;B-Lymphocytes;Benign;Blood;Body System;Bronchoalveolar Lavage;Bronchoalveolar Lavage Fluid;Bronchoscopy;Characteristics;chemokine;Chest imaging;Chronic;Chronic lung disease;Clinical;clinical diagnosis;cohort;COVID-19;COVID-19 patient;cytokine;Data;Development;Diagnosis;Disease;Failure;Fibrosis;fibrotic lung;follow-up;Future;Glass;Goals;HIV;Hospitalization;Immune;Immune response;Immunity;Immunoglobulin A;Immunoglobulin G;Immunologic Stimulation;Immunologics;immunosenescence;Indiana;Infection;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;inflammatory milieu;Inflammatory Response;Influenza;Laboratories;Link;Lung;Lung Diseases;Lung immune response;Lymphocyte;Modeling;Morbidity - disease rate;mortality;Natural Immunity;neutralizing antibody;neutrophil;Nucleocapsid Proteins;participant enrollment;Pathogenesis;Patient Recruitments;patient subsets;Patients;Pattern;peripheral blood;Phenotype;Pneumonia;post SARS-CoV-2 infection;Post-Acute Sequelae of SARS-CoV-2 Infection;post-COVID-19;Process;Proteins;Pulmonary Fibrosis;Pulmonary Inflammation;radiological imaging;Reporting;Residual state;Respiratory Signs and Symptoms;Risk;RNA;Sampling;SARS-CoV-2 infection;SARS-CoV-2 spike protein;severe COVID-19;T cell response;T-Lymphocyte;United States;Universities;Viral;Viral Antigens;Viral Proteins;viral RNA;Virus;Virus Diseases;Work

PROJECT_TITLE: Analysis of immunologic mechanisms in patients with chronic lung disease after acute COVID infection

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: IOWA CITY

ORG_NAME: IOWA CITY VA MEDICAL CENTER

ORG_STATE: IA

PHR: Approximately 78% of Veterans are overweight or obese, which costs millions of dollars in medical and non- medical costs. While treatment of obesity is consistent with the priorities of the VA through personalized, proactive Veteran-driven care, patient compliance has proven inefficient in maintaining long-term weight loss. The central mechanisms regulating macronutrient intake are poorly defined. Our published and preliminary data support the hypothesis that FGF21 acts on the central nervous system to suppress simple sugar intake and regulate sweet taste preference. The proposed research is directly relevant to VA healthcare because of the high disease burden and enormous health care cost that obesity and diabetes is causing in veterans.

PI_NAMEs: POTTHOFF, MATTHEW JOSEPH (contact)

PROJECT_TERMS: Address;Adherence;Adult;Affect;analog;Animal Model;blood glucose regulation;Body Weight;Body Weight decreased;Brain;burden of illness;Calories;Carbohydrates;Caring;Cells;Central Nervous System;clinically significant;combat;Consumption;cost;Data;Desire for food;Development;Diabetes Mellitus;Diet;dietary;economic cost;Effectiveness;Endocrine;Energy Intake;Epidemic;Fatty acid glycerol esters;Feedback;Feeding behaviors;fibroblast growth factor 21;Fibroblast Growth Factor Receptors;Food;Food Energy;Funding;Genes;Glucose;Glutamates;Goals;Grant;Health Care Costs;Healthcare;Homeostasis;Hormones;Human;Hypothalamic structure;improved;innovation;insight;Intake;Lipids;liver function;Macronutrients Nutrition;Mediating;Medical;Metabolic Diseases;Metabolic dysfunction;metabolic profile;Metabolic syndrome;Modeling;molecular targeted therapies;Mus;neural circuit;Neurons;new therapeutic target;novel;novel therapeutics;Nucleus solitarius;Nutrient;Obesity;obesity treatment;Organism;Overweight;paraventricular nucleus;Pathway interactions;Patient Compliance;Peripheral;pharmacologic;Physiological;Population;preference;Production;Proteins;Public Health;Publishing;Quality of life;receptor;Regulation;Research;response;Rewards;Rodent;Saccharin;Signal Transduction;Single Nucleotide Polymorphism;social;Source;sugar;sweet taste perception;Sweetening Agents;Taste Perception;Taste preferences;Therapeutic;Time;tool;Veterans;Waist-Hip Ratio;Weight Gain

PROJECT_TITLE: Central Mechanisms Regulating Macronutrient Intake

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 ENDA-L (01)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Digestive Diseases;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: GAINESVILLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Obesity is a major public health problem that underlies many medical conditions, including diabetes, vascular disease, and brain dysfunction, which result from several pathophysiological mechanisms. The proposed project involves a retrospective analysis of an existing bariatric surgery cohort to examine long-term (>36 months) cognitive and brain outcomes following bariatric surgery in severely obese adults. A prospective study will also be conducted to understand the role of the vagus in cognitive and brain outcomes through two manipulations in the context of bariatric surgery (vagotomy and transcutaneous vagus nerve stimulation).

PI_NAMEs: COHEN, RONALD A;PORGES, ERIC  (contact);WILLIAMSON, JOHN B

PROJECT_TERMS: Address;adult obesity;Affect;age acceleration;age effect;aging related;Anterior;Antioxidants;bariatric surgery;Biological Markers;Blood;blood glucose regulation;Blood Vessels;Body mass index;Body Weight decreased;Brain;brain dysfunction;brain health;Cardiovascular Diseases;Cerebrum;Clinical;Clinical Treatment;Cognition;Cognitive;cognitive benefits;cognitive function;cohort;Communication;comorbidity;cytokine;Data;design;Diabetes Mellitus;Eating Behavior;Encephalitis;Enrollment;Evaluation;Exhibits;follow up assessment;follow-up;Functional Magnetic Resonance Imaging;Gastric Bypass;glucose metabolism;Glutathione;gut microbiome;Health;hemodynamics;Heterogeneity;Hybrids;Impaired cognition;improved;Individual Differences;Inflammation;inflammatory marker;Insulin;Investigation;Knowledge;Link;Long-Term Effects;Longitudinal cohort;Magnetic Resonance Spectroscopy;Measures;Mediating;Medical;Metabolic;Methods;mild cognitive impairment;Morbid Obesity;myoinositol;N-acetylaspartate;neural;Neurocognitive;Neurodegenerative Disorders;neuroimaging;neuroinflammation;Neurons;neurophysiology;Neurophysiology - biologic function;Non-Insulin-Dependent Diabetes Mellitus;normal aging;Obesity;Obesity Epidemic;older adult;Operative Surgical Procedures;Outcome;Parents;Participant;Patients;Persons;Physical Function;Physiological;Physiology;Plasma;preservation;prospective;Prospective cohort;Prospective Studies;Public Health;randomized, clinical trials;response;Rest;Risk Factors;Rodent Model;Role;Satiation;stem;Stomach;systemic inflammatory response;Therapeutic;treatment response;Vagotomy;vagus nerve stimulation;Vagus nerve structure;Vascular Diseases;Weight;white matter

PROJECT_TITLE: WISE II - Obesity and Type-2 Diabetes: Bariatric Surgery Effects on Brain Function

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: PULLMAN

ORG_DEPT: PHARMACOLOGY

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Project Narrative Advanced prostate cancer has increasingly developed a lethal neuroendocrine phenotype as a consequence of widespread use of highly potent antiandrogens in castration-resistant prostate cancer. This is a significant clinical challenge raising an urgent need to develop new effective molecularly targeted therapies to improve patient survival. The proposed studies aim to define the mechanistic basis and functional role of tryptophan hydroxylase 1 and its downstream effectors in neuroendocrine prostate cancer. Our studies will provide new fundamental molecular insights into neuroendocrine prostate cancer pathogenesis and progression, laying the foundations for developing a repurposing targeted strategy capable of rapid clinical translation to treat neuroendocrine prostate cancer, which currently remains incurable.

PI_NAMEs: WU, BOYANG  (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: Ablation;Accounting;advanced prostate cancer;Anabolism;Androgen Antagonists;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Anti-androgen Therapy;Automobile Driving;Biochemical;Bioinformatics;Biological;Biological Assay;Biological Markers;bone;Cancer Patient;cancer subtypes;Cell Line;Cell model;Cell Proliferation;Characteristics;Clinical;clinical translation;Clinical Trials;clinically relevant;cohort;Collection;Coupled;Data;Development;Diagnosis;Differentiation and Growth;E2F transcription factors;Environment;enzalutamide;Enzymes;Event;Foundations;FOXM1 gene;FRAP1 gene;Future;Genes;Genetic;genetic approach;genetic signature;Genetic Transcription;genome-wide;Glutamine;Goals;Growth;Growth and Development function;high risk;Human;improved;In Vitro;in vivo;Incidence;inhibitor;insight;Invaded;Malignant neoplasm of prostate;Maps;Mediating;Molecular;molecular targeted therapies;Morphology;mouse model;Mus;Neoplasm Metastasis;neural;neuroendocrine differentiation;neuroendocrine phenotype;Neuroendocrine Prostate Cancer;Neuroendocrine Tumors;Neurohormones;Neuronal Plasticity;Neuropeptides;Neurosecretory Systems;Neurotransmitters;new therapeutic target;Oncogenes;Oncogenic;Organoids;Outcome;Pathogenesis;patient derived xenograft model;Patients;Peripheral;pharmacologic;Phenotype;Platinum;Play;pre-clinical;Production;Prognosis;prognostic;prognostic value;programs;Prostate Adenocarcinoma;prostate cancer cell;Prostate Cancer therapy;Receptor Signaling;Repression;Resistance;response;Role;Sampling;Series;Serotonin;Signal Transduction;stemness;success;targeted treatment;Testing;Therapeutic;therapeutic target;therapy resistant;Time;trait;transcriptomics;Transgenic Mice;translational impact;translational potential;Tryptophan 5-monooxygenase;tumor growth;tumor xenograft;Viscera;Xenograft procedure

PROJECT_TITLE: Elucidating the Role of Tryptophan Hydroxylase 1 in Neuroendocrine Prostate Cancer

STUDY_SECTION: CCB

STUDY_SECTION_NAME: Cancer Cell Biology Study Section[CCB]


PHR: There is a high prevalence of pain disorders among US veterans when compared to the general population, with 50% of older veterans reporting chronic pain. The etiology of pain disorders in this population is complex, but recent evidence suggests that alcohol drinking may worsen pain symptoms and predispose to pain disorders in later life. These studies will test our overarching hypothesis that chronic alcohol use alters activity in serotonin circuits that modulate central pain circuits. This investigation is directly relevant to veterans because it will identify new potential targets for the treatment of pain disorders exacerbated by chronic alcohol use, which is increasingly common among military personnel.

PI_NAMEs: MARCINKIEWCZ, CATHERINE ANNE (contact)

PROJECT_TERMS: Ablation;Adult;Affective;Affinity Chromatography;Alcohol abuse;alcohol and other drug;Alcohol consumption;alcohol exposure;alcohol use disorder;Alcohols;Amygdaloid structure;Analgesics;Animals;antinociception;Automobile Driving;Brain;Brain Stem;Cell Nucleus;central pain;Chronic;chronic alcohol ingestion;chronic pain;chronic painful condition;Complex;Data;designer receptors exclusively activated by designer drugs;Disinhibition;dorsal horn;dorsal raphe nucleus;drug of abuse;Electrophysiology (science);Equilibrium;Ethanol;Etiology;Exhibits;experimental study;Exposure to;Fiber;Gene Expression;General Population;Genetic;Goals;Health;Heavy Drinking;High Prevalence;Hyperactivity;Hyperalgesia;Immunohistochemistry;immunoreactivity;in vivo;inflammatory pain;insight;Investigation;late life;Link;Literature;Mechanics;Mediating;Military Personnel;military veteran;Mus;neural;neuromechanism;Neurons;Nociception;Pain;Pain Disorder;pain inhibition;Pain management;pain perception;pain sensitivity;pain symptom;Pathway interactions;Photometry;Population;Posterior Horn Cells;Predisposition;Prosencephalon;raphe nuclei;receptor expression;Recording of previous events;Reporting;response;Reverse Transcriptase Polymerase Chain Reaction;Ribosomes;Role;Self Medication;Serotonin;serotonin receptor;Serotonin Receptor 5-HT2C;Signal Transduction;Slice;Spinal;Spinal Cord;Spinal cord posterior horn;Structure of paraventricular nucleus of thalamus;Testing;Time;TPH2;Translating;Veterans

PROJECT_TITLE: Serotonergic involvement in the interaction between alcohol and pain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 NURA-N (01)]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: PROJECT NARRATIVE The human brain contains billions of neurons organized into neural circuits by synaptic connections, forming the basis for perception, thought, and behavior. This project examines molecular mechanisms that build electrical synapses, a critical, understudied connection type used during development and in mature circuits. Defects in electrical synapse formation are tied to autism, epilepsy, myopia, and other neurogenetic disorders, thus a mechanistic understanding of their formation will provide a foundation to treat complex neural disorders.

PI_NAMEs: MILLER, ADAM C (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Adopted;Adult;autism spectrum disorder;Behavior;Behavioral;Binding;Biochemical;Biochemistry;Biological;Biological Models;Biological Process;Brain;Cell Adhesion;Cell Culture Techniques;Cell Transplantation;Cells;Cellular biology;Central Nervous System;Chemical Synapse;Chemicals;Co-Immunoprecipitations;Communication;Complex;Cytoplasm;Cytoskeleton;Defect;density;Development;Disease;Electrical Synapse;Electrons;Electrophysiology (science);Epilepsy;Family;Foundations;gap junction channel;Gap Junctions;Genes;Genetic;Goals;Health;Human;human disease;Image;in vivo;in vivo evaluation;Individual;Injury;innovation;insight;Ions;Knowledge;Link;liquid dynamics;Liquid substance;Mauthner's neuron;Mediating;Medical;membrane-associated guanylate kinase;Microscopy;Modeling;Molecular;Motor;Motor output;mutant;Myopia;neural;neural circuit;neural network;Neurodevelopmental Disorder;neurogenetics;Neurons;novel;Outcome;Pathway interactions;Pattern;Perception;Performance;Phase;Physiology;postsynaptic;presynaptic;Property;Protein Family;Publishing;Role;scaffold;Sensory;Site;small molecule;Specificity;Structure;Synapses;synaptic function;Synaptic Transmission;synaptogenesis;System;therapeutic target;Tight Junctions;tool;trafficking;transmission process;vertebrate embryos;Visualization;Work;Zebrafish

PROJECT_TITLE: Molecular mechanisms of electrical synapse formation in vivo

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Clinical Research;Genetics;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_DEPT: BIOCHEMISTRY

PHR: PROJECT NARRATIVE  This project is to determine the novel role of one type of voltage-gated ion channel in the simultaneous regulation of immune and neural functions in autoimmune-induced injury of the central nervous system. The findings may contribute to the development of a new strategy for treating multiple sclerosis and other autoimmune diseases.

PI_NAMEs: GU, CHEN  (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: 4-Aminopyridine;Action Potentials;Adoptive Transfer;Affect;Auditory;Autoimmune;Autoimmune Diseases;Axon;axon injury;Biological Assay;CD4 Positive T Lymphocytes;Cell Culture Techniques;cell type;Cells;Central Nervous System;central nervous system demyelinating disorder;central nervous system injury;Chronic;CNS autoimmunity;Coculture Techniques;conditional knockout;confocal imaging;Data;Demyelinations;Development;Disease Progression;Disease remission;excitotoxicity;Experimental Autoimmune Encephalomyelitis;FDA approved;Female;Flow Cytometry;Functional disorder;Generations;Image;Imaging Techniques;Immune;immune cell infiltrate;immune function;Immune response;immunoregulation;Impairment;improved;in vivo;Inflammation;Inflammation Mediators;Inflammatory;Injury;injury and repair;innovation;insight;interdisciplinary approach;Interneurons;Ion Channel Gating;knock-down;Knock-out;Knockout Mice;Lesion;Link;LoxP-flanked allele;Lymphocytic Infiltrate;male;Modeling;Motor Activity;Motor Neurons;mouse model;Multiple Sclerosis;Multiple Sclerosis Lesions;multiple sclerosis patient;multiple sclerosis treatment;Mus;Mutation;Myelin;Nerve Degeneration;Neurodegenerative Disorders;Neurologic Deficit;Neuronal Injury;Neurons;Neurophysiology - biologic function;neuroprotection;new therapeutic target;novel;Outcome;Parvalbumins;patch clamp;Pathogenicity;Pathology;Patients;Pharmaceutical Preparations;Play;preservation;Protein Biochemistry;Proteins;Quality of life;Regulation;Relapse;repair strategy;Research;RNA Interference;Role;Severities;Signal Transduction;Spinal Cord;Spinocerebellar Ataxias;symptom treatment;T cell infiltration;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic Effect;therapeutic target;trafficking;Transgenic Mice;Transmission Electron Microscopy;treatment strategy;Up-Regulation;voltage;walking speed

PROJECT_TITLE: Mechanisms underlying regulation of injured axons in CNS autoimmunity

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hepatitis;Liver Disease

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: This grant proposal aims to develop, validate, and optimize a noninvasive MRI method for quantifying and mapping pathological changes in liver microstructure (notably, cell sizes and densities) in vivo. The proposal will focus on demonstrating the clinical role of qTDS in assessing hepatic inflammation in patients with nonalcoholic steatohepatitis (NASH) and the ultimate goal of generating a non-invasive diagnostic metric for NASH.

PI_NAMEs: JIANG, XIAOYU  (contact)

PROJECT_TERMS: Alcoholic Hepatitis;Animals;Anxiety;Apoptosis;Applications Grants;Binding;Biological Markers;Blood;Cell Cycle Arrest;Cell Density;Cell Size;Cells;Characteristics;Cholestasis;Cirrhosis;Clinical;clinical application;clinical care;Clinical Management;Clinical Protocols;Clinical Trials;clinically relevant;clinically significant;Complement;Computer Simulation;computerized data processing;density;Development;Diagnosis;diagnosis standard;Diagnostic;diagnostic biomarker;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Disease Management;elastography;experimental study;extracellular;Fatty acid glycerol esters;Fibrosis;Foundations;Future;Goals;graft vs host disease;Hepatocyte;Hepatolenticular Degeneration;Heterogeneity;Histology;Human;human subject;Image;imaging biomarker;Imaging Techniques;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;interest;Interobserver Variability;Liver;liver biopsy;Liver diseases;liver imaging;liver inflammation;Magnetic Resonance Imaging;Maps;Measurement;Measures;Methods;Modeling;Morphologic artifacts;Motion;mouse model;Nodule;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;noninvasive diagnosis;novel;Obesity;Outcome;pandemic disease;Pathologic;Pathologic Processes;Pathology;Patients;Performance;Polyploidy;Procedures;Protocols documentation;Protons;Receiver Operating Characteristics;regenerative;respiratory;Risk;Role;Sampling Biases;Sampling Errors;Scanning;Sensitivity and Specificity;Signal Transduction;simple steatosis;Solid;Solid Neoplasm;Specimen;spectroscopic imaging;Spectrum Analysis;Structure;System;T cell infiltration;Testing;Time;Tissues;tool;Variant;Viral hepatitis;Water;Work

PROJECT_TITLE: in vivo MR characterization of pathological changes in liver microstructures

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Mental Health;Neurodegenerative;Neurosciences;Rare Diseases

PHR: NARRATIVE Antisocial behaviors are common and severe in behavioral variant frontotemporal dementia (bvFTD), yet our understanding of why these behaviors occur remains incomplete. This project will test the hypothesis that aggressive and rule-breaking antisocial behaviors are distinct behaviorally, with different associated patterns of brain damage and different changes to socioemotional neuropsychological functions. Study results will improve clinical understanding for antisocial behaviors in bvFTD patients and guide future efforts to identify, prevent, and treat these problematic behaviors.

PI_NAMEs: DARBY, RICHARD RYAN (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Address;Adolescent;Adult;Affect;Age;Aggressive behavior;Alzheimer's Disease;Analysis of Covariance;anti social;antisocial behavior;Atrophic;Behavior;Behavioral;behavioral phenotyping;behavioral variant frontotemporal dementia;Brain;brain behavior;Brain Injuries;Brain region;cerebral atrophy;Charge;Classification;Clinical;clinical care;Cognitive;Counseling;Crime;Data;Decision Making;Dementia;Development;Early Diagnosis;effective therapy;Emotional;Emotions;Empathy;Executive Dysfunction;Frontotemporal Dementia;Future;Impairment;improved;indexing;Individual Differences;individualized medicine;informant;insight;Knowledge;Lesion;Linear Regressions;Maps;Measures;Methods;MRI Scans;Nervous System Disorder;neural;neural correlate;neuroimaging;Neurologic Symptoms;neuromechanism;Neuropsychology;neuroregulation;non-demented;novel;older adult;Patients;Pattern;perspective taking;Population;prevent;Process;Prognosis;prognostication;Psychopath;Questionnaires;reward processing;Semantics;sex;social;Social Behavior;social relationships;Structure;Symptoms;Testing;Theft;Therapeutic Trials;validation studies;Work;young adult

PROJECT_TITLE: Antisocial Behavior in Frontotemporal Dementia: Behavioral Phenotypes, Neural Markers, and Decision-Making Mechanisms

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Childhood Injury;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Stroke;Unintentional Childhood Injury

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative Perinatal hypoxic-ischemic (HI) brain injury causes long-term neurological disability, morbidity, and death in infants. Using neonatal mouse models, we will uncover the mechanisms of redox imbalance in the brain that leads to oxidative stress after the oxygen deprivation/reperfusion associated with HI injury. Our line of research will pursue two recently identified metabolic pathways that may help to prevent, rather than just mitigate the damage, and to protect the infant’s brain from HI injury.

PI_NAMEs: GALKIN, ALEXANDER  (contact);GROSS, STEVEN S;TEN, VADIM S

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Acute;Adult;alpha-glycerophosphoric acid;alternative oxidase;Amino Acids;Ammonia;Ammonium;Asphyxia Neonatorum;Astrocytes;Blood flow;Brain;Brain Injuries;Brain Ischemia;brain tissue;Cardiovascular Diseases;cell type;Cerebrum;Citric Acid Cycle;cofactor;Complex;Data;deprivation;Development;dihydrolipoamide dehydrogenase;Dissociation;Early Diagnosis;Electron Transport;Energy Metabolism;Enzymes;Equilibrium;Flavin Mononucleotide;Flavins;Generations;Glycolysis;Hydrogen Peroxide;hypoxic ischemic injury;Hypoxic-Ischemic Brain Injury;Image;Impairment;In Vitro;in vivo;in vivo Model;Infant;Infant Mortality;Infarction;Injury;Intervention;Ischemia;ischemic injury;Ischemic Stroke;Keto Acids;ketoglutarate dehydrogenase;Ketoglutarate Dehydrogenase Complex;Knowledge;Lead;Left;Link;mass spectrometric imaging;Measures;Mediating;Metabolic;metabolic abnormality assessment;Metabolic Control;Metabolic Pathway;Metabolism;metabolomics;Mitochondria;Modeling;Molecular;Monitor;Morbidity - disease rate;mouse model;Mus;NADH;Neonatal;neonatal brain;neonatal hypoxic-ischemic brain injury;neonatal mice;Neurologic;Neurological disability;Neurons;novel;novel diagnostics;novel therapeutics;nucleotide metabolism;Obstruction;outcome prediction;oxidation;Oxidation-Reduction;Oxidative Phosphorylation;Oxidative Stress;Oxidoreductase;Oxygen;Pathway Analysis;Pathway interactions;Perinatal Hypoxia;Play;prevent;Production;Publishing;Purine Nucleotides;Pyruvate Dehydrogenase Complex;quinol oxidase;Reactive Oxygen Species;Regulation;Reperfusion Injury;Reperfusion Therapy;Research;response;Role;Scheme;small molecule;Source;Spatial Distribution;Stroke;Succinates;Superoxides;Therapeutic;Time;tissue injury;tissue mapping;Tissue Survival;Tissues;tool;Transgenic Mice;Traumatic Brain Injury;Visualization

PROJECT_TITLE: Metabolic Landscape and Mitochondrial ROS Balance in Brain Ischemia/Reperfusion

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-T (02)]


PHR: PROJECT NARRATIVE Squamous cancer is a common and deadly cancer type and can arise from diverse organ sites. This proposal will apply state-of-the-art technologies to investigate basic mechanisms underlying the development of squamous cancer, which will imply potential therapeutic strategies for this deadly cancer type.

PI_NAMEs: ZHANG, XIAOYANG  (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: 3-Dimensional;AIM2 gene;Architecture;Binding;Binding Sites;Biological Assay;Biological Markers;Cancer Etiology;cancer type;Cervix Uteri;Cessation of life;Chemotherapy and/or radiation;Chromatin;Chromatin Loop;Chromatin Structure;cofactor;cohesin;Complex;CRISPR/Cas technology;Data;Development;Dissection;Distal;DNA;Enhancers;epigenome editing;Esophagus;Gastrointestinal tract structure;Gene Expression Regulation;Genes;Genetic Transcription;Genetically Engineered Mouse;Genome;genome editing;Genomic approach;Genomics;Human Genome;Knowledge;Link;Lung;Malignant Neoplasms;Malignant Squamous Cell Neoplasm;Mediating;Methods;Modeling;Molecular;Mus;novel;Oncogenes;Oncogenic;Operative Surgical Procedures;Organ;Organoids;overexpression;Play;programs;promoter;Proteomics;recruit;Regulatory Element;Role;RUNX1 gene;Sampling;Series;Site;Skin;small molecule;Specific qualifier value;targeted treatment;Technology;Testing;Therapeutic;therapeutic target;three dimensional structure;Tissues;transcription factor;Transcription Factor AP-1;Transcriptional Activation;Transcriptional Regulation;Tumor Suppressor Proteins

PROJECT_TITLE: SOX2 acts in the 3D genome of squamous cancer

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Cancer;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Narrative Combination therapies cure some cases of aggressive lymphoma, but attempts to make improved drug combinations are rarely successful in clinical trials. This project will develop computational models of multiple drugs acting on populations of cancer cells, within populations of patients, to simulate clinical trials. We will use these models to understand why some combination therapies have succeeded and others have failed in past trials, and to assist the design of forthcoming trials of new combination therapies to give them the greatest likelihood of curing more patients with lymphoma.

PI_NAMEs: PALMER, ADAM CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Adopted;Advanced Malignant Neoplasm;Affect;age group;American College of Radiology Imaging Network;Antineoplastic Agents;Biological Markers;Calibration;cancer cell;Case Study;chemotherapy;Classification;Clinical;Clinical Data;clinical efficacy;Clinical Trials;clinically relevant;cohort;Collaborations;Combination Drug Therapy;Combined Modality Therapy;Computer Models;Computer Simulation;Consolidation Therapy;curative treatments;Data;design;dosage;Dose;drug action;Drug Combinations;drug efficacy;Drug Interactions;Drug Kinetics;Drug Modelings;Drug resistance;drug sensitivity;Eastern Cooperative Oncology Group;Enrollment;Evolution;Factor Analysis;Failure;FDA approved;Formulation;Future;Genetic Transcription;Goals;Heterogeneity;Human;improved;Individual;Industry;innovation;insight;Kinetics;large cell Diffuse non-Hodgkin's lymphoma;Learning;liquid biopsy;Lymphoma;Malignant Neoplasms;Measures;Methods;model design;Modeling;Modernization;multi-scale modeling;Mutation;neoplastic cell;new combination therapies;novel;novel drug combination;novel therapeutics;older patient;Outcome;Output;patient population;patient variability;Patients;Pharmaceutical Preparations;phase III trial;Population;predicting response;predictive modeling;predictive tools;Process;Prognosis;prospective;Publishing;Refractory;Regimen;Relapse;Research;Resistance;response;simulation;Solid;success;targeted treatment;Technology;Testing;Theoretical model;theories;Toxic effect;Treatment Protocols;treatment response;trial design;trial enrollment;tumor;tumor heterogeneity;virtual;Work

PROJECT_TITLE: Modeling and analysis of curative combination therapy for Diffuse Large B-Cell Lymphoma

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Hypertension;Prevention

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: The use of complex, multi-component interventions has become an increasingly important strategy for cardiovascular disease prevention, screening and treatment, but in the face of the complexity of these interventions it is difficult to specify before a trial launches the optimal intervention package and its optimal intervention component “doses”, as existing non-adaptive and adaptive methods require. Previously, we established “Learn-As-you-GO” or LAGO designs for logistic regression for a single binary outcome, where the intervention package is increasingly refined within each successive stage, optimizing for cost-effectiveness and the attainment of pre-planned study goals. In this project, we will develop the mathematical theory and open- source software for adaptive LAGO designs for the range of outcome data typically encountered and across a number of design options not covered by our initial 2021 Annals of Statistics paper, focusing on cost- effectiveness, reaching a pre-planned study goal at pre-specified statistical power even when pre-trial expectations are not met, and comparisons of LAGO to existing non-adaptive designs, motivated by the EXTRA-CVD (U01HL142099) and PULESA-Uganda (UG3HL154501) studies, the latter of which is an ongoing NHLBI-supported project for which the contact PI serves as study statistician that is funded to apply LAGO at two pre-planned stages after baseline.

PI_NAMEs: LOK, JUDITH JACQUELINE;SPIEGELMAN, DONNA L (contact)

PROGRAM_OFFICER_NAME: EINHORN, PAULA T

PROJECT_TERMS: adaptive learning;Adherence;Alternative Therapies;analytical method;Blood Pressure;blood pressure control;Blood Pressure Monitors;Cardiology;cardiovascular disorder prevention;Cardiovascular system;care coordination;Cholesterol;Client;Communities;Complex;Computer software;cost;cost effectiveness;Counseling;Data;design;Development;dissemination science;Dose;Effectiveness;Electronic Health Record;Equation;Equipment;expectation;Failure;Funding;Future;Goals;hands-on learning;Health Status;Health system;Home;Home Blood Pressure Monitoring;hypertension control;implementation science;implementation trial;improved;Individual;innovation;Intervention;intervention cost;intervention effect;Intervention Studies;Intervention Trial;Knowledge;Laboratories;Learning;Learning Module;Linear Models;Logistic Regressions;mathematical theory;Measures;Medication Management;method development;Methodology;Methods;multi-component intervention;National Heart, Lung, and Blood Institute;Nurses;open source;Outcome;Outcome Study;Paper;Participant;patient population;Patients;Persons;preservation;Prevention;Prevention education;Prevention Research;Principal Investigator;Programming Languages;programs;Protocols documentation;Provider;Public Health;Publications;Regression Analysis;Reporting;Research;Research Personnel;Risk;Risk Reduction;Running;Sample Size;scale up;Scientist;screening;Social Network;Software Design;Specific qualifier value;Statistical Data Interpretation;Statistical Methods;statistics;support tools;Testing;theories;therapy design;Time;trial design;Uganda;United States Food and Drug Administration;Update;user-friendly;Visit;Writing

PROJECT_TITLE: Learn-As-you-GO (LAGO): An innovative adaptive design for multi-component intervention studies in cardiology and public health

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Endocrine Disruptors;Foodborne Illness;Genetics;Human Genome;Lung;Lung Cancer;Skin Cancer

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Narrative Some microRNAs can act as oncogenes or tumor suppressors by suppressing the expression of tumor suppressor or oncogene proteins. The proposed studies will determine whether microRNAs overexpressed in skin cancers caused by chronic arsenic exposure contribute to the development of skin cancer by targeting proteins in common with known oncogenic microRNAs.

PI_NAMEs: STATES, J CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Alternative Splicing;Aneuploidy;Arsenic;arsenic-induced carcinogenesis;Arsenites;Automobile Driving;Cancer Etiology;carcinogenesis;carcinogenicity;Cell Culture Techniques;Cell Line;Cell model;cell transformation;cell type;Cells;Chromosomal Instability;Chronic;Chronic Disease;Clone Cells;Complex;Data;Development;DNA sequencing;Dose;drinking water;Environmental Health;Epigenetic Process;epigenetic silencing;Event;exposed human population;Exposure to;Funding;fusion gene;Gene Expression;Gene Fusion;gene induction;Gene Targeting;Genes;Human;in vitro Model;India;insight;Investigation;Karyotype;keratinocyte;Knowledge;Learning;Longitudinal Studies;Malignant Neoplasms;Messenger RNA;metaplastic cell transformation;MicroRNAs;Mitotic;Modeling;Modification;Molecular;mRNA Expression;Mutation;Nature;novel;Oncogenes;Oncogenic;Oncoproteins;overexpression;Parents;Pathway interactions;Persons;Phenotype;Preparation;Proteins;Proteomics;RNA metabolism;RNA Splicing;Role;Skin Cancer;Skin Carcinogenesis;skin organogenesis;Squamous cell carcinoma;Tissue-Specific Gene Expression;Tissues;transcriptome sequencing;translational framework;tumor;Tumor Suppressor Genes;Tumor Suppressor Proteins;tumorigenesis;Work

PROJECT_TITLE: Mechanism for arsenic induced carcinogenesis

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Racial and Ethnic Minority Health Research

PHR: PROJECT NARRATIVE Hispanic adults face disparities in obesity, type 2 diabetes, and nonalcoholic fatty liver disease relative to non- Hispanic white adults, driven in part by higher consumption of sugar-sweetened beverages (SSBs). Requiring sugar warnings on SSB containers could reduce excessive SSB purchases and consumption, but studies have not examined how such warnings influence SSB purchases especially in Hispanic populations. The proposed research will evaluate the effectiveness of sugar warnings on SSBs at reducing SSB purchases among Hispanic adults in the US and in Mexico.

PI_NAMEs: HALL, MARISSA  (contact);SMITH TAILLIE, LINDSEY

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: Adult;Affect;Age;Area;arm;Attention;Behavior;behavior change;behavior influence;Behavioral Sciences;Beverages;community partners;consumer behavior;Consumption;Country;Data;design;Diabetes Mellitus;Disease;Disparity;Eating Behavior;effectiveness evaluation;Environment;Equation;Evaluation;Evaluation Studies;experimental study;Face;Food;Food Industry;Formulation;Goals;Healthy Eating;Hispanic;hispanic community;Hispanic Populations;Household;Industry;Intake;Interview;Juice;Label;Link;Longitudinal Surveys;Measures;Mediating;Mediator;Mexican;Mexico;Modeling;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;North Carolina;Not Hispanic or Latino;nutrition;Nutrition Policy;Nutritional;Nutritional Study;Obesity;obesity prevention;Participant;Policies;Population;primary outcome;Product Packaging;Proliferating;psychologic;Public Health;Randomized;Reaction;recruit;Reducing diet;Research;research study;response;secondary outcome;Strategic Planning;sugar;Surveys;sweetened beverage;Sweetening Agents;Taxes;Time;Total Sugar;two-arm trial;United States National Institutes of Health;Visit;warning label;Work

PROJECT_TITLE: Evaluating the impact of sugar warnings on beverage purchases in Hispanic populations

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Duchenne/ Becker Muscular Dystrophy;Heart Disease;Machine Learning and Artificial Intelligence;Muscular Dystrophy;Networking and Information Technology R&D (NITRD);Orphan Drug;Pediatric;Pediatric Cardiomyopathy;Rare Diseases

PHR: NARRATIVE Dystrophin associated heart dysfunction is a leading cause of death in patients with Duchenne and Becker Muscular dystrophy (DMD/BMD) and carriers of DMD and BMD (MDC); however, the evolution of heart dysfunction is not well-understood. The central objectives of this proposal are to elucidate this evolution of heart dysfunction in patients with DMD/BMD/MDC, identify measures from cardiac MRI images that can predict death or significant heart disease, and create a risk toolkit accessible to clinicians around the world. This study will create a large clinical and cardiac MRI registry of dystrophin associated heart dysfunction and will utilize advanced image analysis techniques, including deep learning neural networks, to comprehensively evaluate every patient; this proposal has the potential to improve the quality of life in patients with dystrophin associated heart dysfunction by allowing for earlier and more intensive therapy in patients with severe disease and by identifying surrogate outcome measures for use in therapeutic trials.

PI_NAMEs: GOERGEN, CRAIG J.;HOR, KAN N;LIN, GUANG ;MARKHAM, LARRY W.;SOSLOW, JONATHAN HARVEY (contact)

PROGRAM_OFFICER_NAME: LI, HUIQING

PROJECT_TERMS: Address;Age;Algorithms;Becker Muscular Dystrophy;Biological Markers;biomarker identification;Biomedical Engineering;Blood;Cardiac;cardiac magnetic resonance imaging;Cardiomyopathies;Cardiovascular Diseases;Cardiovascular system;Caring;causal model;Cause of Death;Cessation of life;Charge;Clinical;clinical care;Clinical Data;Clinical Research;Clinical Trials;cloud based;cohort;Collaborations;collaborative approach;Collection;Complex;Confidence Intervals;coronary fibrosis;Data;deep neural network;Diagnostic;Disease;Disease Progression;Duchenne cardiomyopathy;Duchenne muscular dystrophy;Dystrophin;Enrollment;Evaluation;Evolution;follow-up;Funding;Future;General Population;Goals;Grant;Heart Diseases;Heart failure;heart imaging;high risk;Image;Image Analysis;imaging biomarker;improved;Incidence;indexing;individual patient;innovation;Institution;kinematics;Knowledge;Laboratories;Left Ventricular Ejection Fraction;Machine Learning;machine learning model;Magnetic Resonance;Measures;Methods;Modeling;mortality;Muscular Dystrophies;mutation carrier;Myocardial dysfunction;Myopathy;National Heart, Lung, and Blood Institute;Natural History;neural network;novel;novel marker;Outcome;Outcome Measure;Patient risk;Patients;Performance;Pharmaceutical Preparations;Phenotype;population based;predictive modeling;premature;Productivity;prospective;Protocols documentation;Quality of life;Registries;Research;research study;Respiratory Failure;Risk;Sample Size;Site;Standardization;Statistical Models;Supportive care;targeted treatment;Techniques;Therapeutic Trials;Time;Tissues;tool;United States National Institutes of Health;Work

PROJECT_TITLE: Modeling Mortality in Duchenne Muscular Dystrophy Cardiomyopathy: Identification of Surrogate Outcome Measures for DMD Drug Trials

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


ORG_CITY: CINCINNATI

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Narrative  Bacterial metallophores are remarkable molecules that can chelate metals and also bind to dedicated receptor proteins on the bacterial surface. We will design and develop a chemogenetic platform in which the bacterial transporters would be ectopically expressed on CAR-T cells to create a genetically-encoded reporter system to track genome-edited cells in vivo at any depth, using nuclear imaging.

PI_NAMEs: KOTAGIRI, NALINIKANTH  (contact)

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: Adoptive Cell Transfers;Affinity;analog;Animal Model;Antigens;Autoimmune Diseases;autologous lymphocytes;Back;Bacteria;Binding;Biodistribution;Biological;Cardiovascular system;Carrier Proteins;CD19 gene;Cell surface;Cell Survival;Cell Therapy;cell type;Cells;Chelating Agents;chelation;Chemicals;Chemistry;chimeric antigen receptor T cells;Clinical;clinical imaging;Clinical Trials;clinically relevant;commensal microbes;Complex;Contrast Media;Copper;CRISPR/Cas technology;Dedications;design;detection limit;Development;Diagnosis;diagnostic tool;DNA;Drug Kinetics;Elements;Engineering;Escherichia coli;Evaluation;expression vector;fluorescence imaging;Genes;Genetic;Genetic Engineering;genome editing;Green Fluorescent Proteins;Image;Imaging Device;Imaging ligands;imaging modality;imaging probe;Immune;Immune Evasion;immunogenicity;in vivo;Individual;Innate Immune System;innovation;Iron;Label;Ligands;Liquid substance;Luciferases;Malignant Neoplasms;Mammalian Cell;metal chelator;Metals;Modality;molecular imaging;Nature;Nerve Degeneration;non-invasive monitor;novel;nuclear imaging;pathogenic bacteria;pathogenic Escherichia coli;Patients;Phase;Physiological;Positron-Emission Tomography;Process;programmed cell death protein 1;Radioisotopes;radiotracer;real-time images;receptor;Reporter;Reporting;Role;Staphylococcus aureus;Surface;System;T-Lymphocyte;Techniques;Testing;Therapeutic;Time;Transfection;Tumor Tissue;uptake;vector

PROJECT_TITLE: Genetically-encoded molecular imaging of genome-edited immune cells

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: RICHMOND

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE In response to drug use, brain transcription factors regulate gene expression changes within the cells that comprise brain reward regions, which is thought to drive the damaging behavioral changes that define drug addiction. Here, we propose research utilizing synthetic biology approaches to reprogram the function of key brain transcription factors to resolve their exact contribution in drug-specific transcription and behaviors. This research and the application of these synthetic transcription factors has the potential to be used as preclinical tools to uncover novel targets for pharmacotherapies to combat the pathogenesis of specific drug addictions.

PI_NAMEs: HAMILTON, PETER JAMES (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: addiction;Affect;Animals;ATAC-seq;Behavior;Behavioral;Behavioral Assay;Biological;Brain;brain reward regions;Candidate Disease Gene;candidate identification;Cartoons;Cell Nucleus;cell type;Cells;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Cocaine;Cocaine Dependence;cocaine exposure;cocaine related behaviors;cocaine self-administration;cocaine use;cofactor;combat;conditioned place preference;Data;design;Dose;Drug Addiction;Drug Targeting;Drug usage;drug use behavior;Epigenetic Process;experience;Exposure to;Family;Future;Gene Expression;Gene Expression Profiling;Gene Family;gene product;Gene Targeting;Genes;Genetic Transcription;Goals;in vivo;innovation;Intravenous;Knowledge;Laboratories;Literature;Mediating;member;Molecular;Morphine;multiple omics;Mus;neuroadaptation;Neurons;new therapeutic target;next generation;novel;novel strategies;Nucleus Accumbens;Opiate Addiction;Opioid;opioid exposure;opioid injection;opioid use;p65;Pathogenesis;Pharmaceutical Preparations;Pharmacotherapy;Physiological;Population;pre-clinical;Process;programs;protein function;Proteins;Publishing;recruit;Repression;Research;response;reward circuitry;Rewards;Rodent;Saline;Self Administration;single nucleus RNA-sequencing;Stimulant;stimulant dependence;synthetic biology;Testing;Tissues;tool;Transcript;Transcription Coactivator;transcription factor;Transcriptional Regulation;transcriptome sequencing;transcriptomic profiling;Variant;Viral;Work;XCL1 gene;Zinc Fingers

PROJECT_TITLE: Reprogramming KZFP function to understand drug-specific transcription and behavior

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_NAME: NEW YORK GENOME CENTER

PHR: PROJECT NARRATIVE Cardiovascular diseases (CVD) are one of the leading causes of death and disability worldwide, resulting in a heavy economic burden. Novel population-specific risk factors for CVD have recently been identified from genome-wide association studies (GWAS) in individuals from non-European ancestries; here, using multi- ancestry GWAS, we develop and apply a suite of computational and experimental innovations to increase identification of causal variants, relevant cell types and target genes. In particular, we introduce scalable methods to unite high-throughput genetic perturbations and precise insertion of human genetic variants with single-cell sequencing, which can pinpoint causal variants for CVD and the genes they regulate locally and globally across the genome.

PI_NAMEs: SANJANA, NEVILLE  (contact)

PROGRAM_OFFICER_NAME: YAN, YE

PROJECT_TERMS: 3-Dimensional;Address;Adenine;Age;Architecture;Atlases;base editor;Binding Sites;biological adaptation to stress;Biological Assay;Biology;Blood;Blood Cells;Body System;Cardiology;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular disorder therapy;cardiovascular risk factor;causal variant;Cause of Death;Cell Communication;Cell Line;Cell Physiology;cell type;Cells;Chromosome Mapping;Clustered Regularly Interspaced Short Palindromic Repeats;Coagulation Process;Complex;computational suite;Consensus;Coronary Arteriosclerosis;Correlative Study;Coupled;CRISPR screen;Cytosine;Data;disability;Disease;Disease susceptibility;Economic Burden;electric impedance;Elements;Endothelial Cells;Enhancers;Enzymes;Erythroid;Erythroid Progenitor Cells;Etiology;European ancestry;flexibility;Foundations;Functional disorder;functional genomics;Future;Genes;Genetic;Genetic Diseases;Genetic Transcription;genetic variant;Genetic Variation;Genome;Genome engineering;Genome Mappings;genome wide association study;genome-wide analysis;genomic variation;guided inquiry;Healthcare;Hematopoietic stem cells;Human;Human Genetics;Human Genome;Hypertension;Immune response;improved;Individual;innovation;interdisciplinary approach;Link;Linkage Disequilibrium;Location;Maps;Methods;MicroRNAs;migration;Molecular;mortality;multiple omics;Myocardial Infarction;novel;novel therapeutics;Phenotype;Population;progenitor;protein expression;Proteins;Public Health;Regulatory Element;Regulatory Pathway;Resolution;RNA;Shapes;single cell sequencing;single cell technology;Standardization;Structure;Systems Biology;Testing;Therapeutic;tool development;trait;transcription factor;Untranslated RNA;Variant;Work

PROJECT_TITLE: Scalable multi-ancestry functional genomics of blood traits and cardiovascular disease

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Pediatric

ORG_CITY: MIAMI

ORG_DEPT: PSYCHOLOGY

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

PHR: Project Narrative  Multisensory attention skills—selective attention to unitary audiovisual events (e.g. face and voice of a person speaking), and maintaining and efficiently shifting attention in the context of distracting events—are key building blocks for later development. Using our two new individual difference measures, this research will build an exciting new body of knowledge about the typical development of multisensory attention skills from infancy (3 months) through pre-adolescence (11 years) and reveal the pathways through which they support language and socio-emotional functioning, and in turn, executive functions, and academic achievement. We will do so at a level of detail that is necessary for identifying risk for atypical development in disorders such as autism, and for guiding applications and interventions.

PI_NAMEs: BAHRICK, LORRAINE E (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: 5 year old;Academic achievement;Address;Affect;Age;Attention;autism spectrum disorder;Behavior;biomarker identification;causal model;Child;Child Rearing;Childhood;Code;Cognitive;cognitive development;cognitive function;cohort;Competence;contextual factors;Data;Data Collection;Data Set;Databases;Development;Developmental Process;Disease;Early identification;Education;Emotional;emotional functioning;Environment;Event;executive function;Face;falls;Family;flexibility;Foundations;Grain;Growth;indexing;Individual;Individual Differences;infancy;Infant;Intervention;Knowledge;knowledge base;knowledgebase;Language;Language Development;Learning;Link;longitudinal analysis;Longitudinal cohort;Maintenance;Measures;Mediator;member;Methodology;Modeling;multimodality;multisensory;novel;Outcome;Parent-Child Relations;Parents;Pathway interactions;Performance;Persons;preadolescence;Protocols documentation;Public Health;Readiness;Research;Research Personnel;Risk;Role;Sample Size;Sampling;Schools;Science;selective attention;Shapes;skills;social;Social Development;Social Functioning;social skills;Socioeconomic Status;sound;Speed;symptomatology;Testing;theories;Time;tool;Vision;Voice

PROJECT_TITLE: Intersensory Processing, Developmental Trajectories, and Longitudinal Outcomes

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biomedical Imaging;Kidney Disease;Lupus;Machine Learning and Artificial Intelligence

ORG_CITY: HOUSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Diagnosis of lupus nephritis (LN) using conventional histopathology is challenging and fraught with pitfalls. We propose combining histopathology with information from two independent optical imaging modalities that provide additional biochemical and macromolecular context to LN diagnosis. We develop a multi-modal histology platform to collect co-registered images and combine data using a deep learning architecture to improve the accuracy of LN diagnosis.

PI_NAMEs: REDDY, ROHITH  (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: accurate diagnosis;Address;Adult;Affect;alpha helix;Amino Acids;Architecture;Area;Autoimmune Diseases;beta pleated sheet;Biochemical;Biological Markers;Biometry;Biopsy;Biopsy Specimen;Child;Clinical;Collagen;Complex;Core Biopsy;Data;deep learning;design;Development;Diagnosis;diagnosis standard;Diagnostic;diagnostic accuracy;diagnostic value;Disease;disease heterogeneity;Disease Outcome;disease phenotype;efficacy validation;End stage renal failure;feature selection;Hematoxylin and Eosin Staining Method;Histologic;Histology;Histopathology;Human;human data;human subject;Image;imaging biomarker;imaging modality;improved;instrumentation;interstitial;Kidney;kidney biopsy;Label;Leucocytic infiltrate;Lipids;Lupus Nephritis;Machine Learning;Maps;Measurement;Measures;Metabolic;Methods;Microscopy;Modality;Molecular;molecular imaging;Morphology;mouse model;Mouse Strains;multimodality;Mus;Nucleic Acids;optical imaging;Paraffin Embedding;Pathologist;Pathology;Patient Care;Patients;Preparation;preservation;Prognosis;Proteins;Quantitative Evaluations;Resolution;Sampling;Secondary Protein Structure;small molecule;Spatial Distribution;spectroscopic imaging;Speed;Stains;structural imaging;Structure;Surface;Systemic Lupus Erythematosus;Techniques;Thinness;Time;Tissue Embedding;Tissue Preservation;tissue processing;Tissue Sample;Tissues;Training;ultraviolet;United States;Urine;Validation;Variant;Visualization

PROJECT_TITLE: Improving the Accuracy of Lupus Nephritis Diagnosis using Biomarkers Derived from Ultraviolet and Mid-infrared Spectroscopic Imaging

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT RELEVANCE: Temporal patterning of progenitors is critical for generating cellular diversity during retina development. This study will provide insight into the role of a gene that functions in progenitors to regulate specification of retinal neurons generated during early stages of retinal development. This work may facilitate strategies to regenerate cell types lost to disease or injury, such as retinal ganglion cells and cone photoreceptors.

PI_NAMEs: VETTER, MONICA L (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Address;Amacrine Cells;Binding;Binding Sites;cell regeneration;cell type;Cells;Chromatin;Cleavage Under Targets and Release Using Nuclease;Competence;competence factor;Cone;Data;Development;Differentiated Gene;Disease;Early identification;Embryo;Embryonic Development;Family;forkhead protein;FOXP1 gene;Gene Expression;gene function;Generations;Genes;genetic approach;histone modification;horizontal cell;Human;Injury;insight;Knowledge;Mediating;Messenger RNA;Microarray Analysis;MicroRNAs;Molecular;mRNA Expression;Muller's cell;Mus;neurogenesis;Neuroglia;Neurons;Nucleic Acid Regulatory Sequences;Pattern;postnatal;Production;progenitor;protein expression;Regulation;Repression;Retina;Retinal Cone;Retinal Ganglion Cells;retinal neuron;retinal progenitor cell;Rod;Role;Shapes;single cell analysis;single cell ATAC-seq;single-cell RNA sequencing;Specific qualifier value;stem cell differentiation;stem cell genes;Testing;transcription factor;Vision;Work

PROJECT_TITLE: Regulation of Retinal Neurogenesis by Foxp1

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

ORG_STATE: MA

PHR: Project Narrative The proposed research is relevant to public health because it will lead to new knowledge about the causes of imbalance and falls in older adults and to innovative approaches to study sensory contributions to imbalance and central sensory integration. These advancements will provide a foundation for mitigating falls in older adults, including through the use of newly developed therapeutics. The project is relevant to NIH’s mission because falls in older adults are responsible for substantial disability and are the leading cause of trauma- related death.

PI_NAMEs: KARMALI, FAISAL  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Adult;Age;age difference;age related;age related decline;Aging;Ankle;Biological Assay;Biomechanics;Biometry;Brain;Cardiovascular Physiology;Cessation of life;Classification;Clinical;Clinical Trials;Cognition;cognitive function;cohort;Cohort Studies;Complex;Computer Models;Cues;Data;Defect;Deterioration;disability;Equilibrium;Exhibits;fall risk;falls;Foundations;Functional disorder;Gait;Geriatrics;Goals;hair cell regeneration;Head;Health;heart function;Individual;Individual Differences;innovation;insight;Intervention;kinematics;Knowledge;knowledge of results;Measurement;Measures;Methods;Mission;Modality;Modeling;mortality;Motion;Motor;Motor output;multisensory;Muscle function;muscle strength;Musculoskeletal Equilibrium;neural;Noise;noninvasive brain stimulation;novel therapeutics;older adult;Orthostatic Hypotension;Outcome;Patients;Peripheral;Population;Posture;predictive modeling;Public Health;Recording of previous events;Research;Sensory;sensory input;sensory integration;Sensory Physiology;somatosensory;Surface;Testing;Therapeutic;Translations;Trauma;United States National Institutes of Health;Vestibular dysfunction;vestibular prosthesis;vestibular system;Visual;visual dysfunction;Walking;Weight;Work;young adult

PROJECT_TITLE: Contribution of vestibular dysfunction and its central multisensory integration to imbalance in aging

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative  This project will utilize high resolution adaptive optics scanning light ophthalmoscopy (AOSLO) to investigate the structure, function, and treatment of photoreceptors in human patients with blinding inherited retinal degenerations (IRDs). This study will: 1) Determine the AOSLO cellular phenotypes of cone and retinal pigment epithelial mosaics in IRDs; 2) Correlate cone function with AOSLO structural phenotypes in IRDs; and 3) Investigate the AOSLO structural and functional response to gene therapy. The information gained in this study will aid future studies of IRD, and will pave the way for AOSLO imaging technology to advance gene, cell, and molecular therapies for blinding conditions.

PI_NAMEs: MORGAN, JESSICA I.W. (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: adaptive optics;Aftercare;Area;Blindness;Cell Density;Cells;cellular imaging;Cessation of life;Choroideremia;Clinical Trials;Cone;Cross-Sectional Studies;Darkness;Data;density;Detection;Development;Disease;efficacy evaluation;Evaluation;Evaluation Studies;Exhibits;Eye diseases;fighting;Functional disorder;functional improvement;functional loss;functional outcomes;Future;gene therapy;Genes;Hereditary Disease;Human;Image;imaging modality;Imaging technology;Individual;Inherited;inherited retinal degeneration;Light;Location;Longitudinal Studies;Measurement;Measures;Mediating;Molecular;Morphology;mosaic;multimodality;Ophthalmoscopy;Outcome Measure;patient variability;Patients;Perimetry;Phenotype;Photoreceptors;Physiological;Protocols documentation;Psychophysics;Publishing;Resolution;response;Retina;Retinal Cone;Retinal Diseases;Rod;RPE65 protein;safety assessment;Scanning;sight restoration;Structure;Structure of retinal pigment epithelium;success;Testing;Therapeutic;Therapeutic Intervention;Therapy Evaluation;treatment response;United States Food and Drug Administration;Vision;visual stimulus;waveguide;Work

PROJECT_TITLE: Retinal structure, function and response to gene therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: Project Narrative Glaucoma is a disease identified by increased pressure within the eye and progressive death of neurons in the back of the eye that eventually leads to blindness. Current treatment options for disease only include reducing elevated pressure, but patients are sometimes resistant to established treatments. We will use human neurons and a regenerative therapy to rescue visual neurons from dying which will provide progress towards clinical trials in glaucoma patients with a focus on precision medicine.

PI_NAMEs: SHARMA, TASNEEM PUTLIWALA (contact)

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: Address;Affect;Animal Model;Apoptosis;axon injury;Axonal Transport;Axotomy;Back;Biological Models;Blindness;cell injury;Cell Physiology;Cicatrix;Clinical;Clinical Research;Clinical Trials;Collagen;Complex;cost;Crush Injury;Data;deprivation;Development;Diagnosis;Disease;economic cost;Evaluation;experimental study;Eye;Foundations;Future;Glaucoma;Goals;Government;Grant;Human;human induced pluripotent stem cells;improved;in vivo;induced pluripotent stem cell;innovation;Intracranial Pressure;invention;MAP Kinase Gene;Mediating;Methods;Modeling;Mus;Natural regeneration;Nerve Degeneration;Nerve Regeneration;Neurites;neuron loss;neuronal cell body;Neurons;neuroprotection;Neuroprotective Agents;neurotrophic factor;novel;Obstruction;Optic Disk;Optic Nerve;Outcome;overexpression;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Perfusion;Persons;Pharmacotherapy;Physiologic Intraocular Pressure;PIK3CG gene;precision medicine;preclinical study;preservation;pressure;Prevalence;prevent;protective effect;Regenerative pathway;regenerative therapy;Regulation;Research;Resistance;Resources;Retina;retinal ganglion cell degeneration;retinal ganglion cell regeneration;Retinal Ganglion Cells;Risk Factors;Rodent;Role;Signal Transduction;stem cell technology;stem cells;System;Testing;Therapeutic;Therapeutic Effect;Therapeutic Intervention;tool;Translating;Translational Research;Validation;Visual

PROJECT_TITLE: Therapeutic intervention to target human glaucoma pathogenesis


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Brain Disorders;Data Science;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Clinical researchers collect brain images from multiple modalities to enhance diagnosis and treatment of neurode  generative disorders (NDs), yet their impact is constrained due to a lack statistical methods that model information both within and across images. This proposal develops a new Bayesian framework to address the theoretical and computational challenges of jointly modeling structural and network brain images, exploiting their linkage to ad  vance the study of ND. The goal is to provide imaging statisticians and practitioners with a set of inferential tools that harness the potential of existing multimodal imaging data to improve the study of cognitive theory, disease progression, and biomarker development.

PI_NAMEs: GUHANIYOGI, RAJARSHI ;SCHEFFLER, AARON WOLFE (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Address;advanced disease;Aging;Alzheimer's Disease;Atrophic;Bayesian Analysis;Bayesian Method;Bayesian Modeling;Biological;biomarker development;Brain;Brain imaging;Brain scan;Cells;Characteristics;Clinical;Cognitive;cognitive testing;Collection;Communities;comparative;Complex;Computer Models;Computer software;computerized tools;cost;Data;data acquisition;Data Analyses;Data Set;Detection;Diagnosis;Diagnostic;Disease;disease classification;Disease Progression;Goals;Health;Heterogeneity;heterogenous data;high dimensionality;high resolution imaging;Image;Image Analysis;imaging modality;Impaired cognition;improved;indexing;information model;Information Networks;innovation;Joints;Learning;Life Expectancy;Link;Measures;Memory;Methods;Modality;Modeling;Monitor;multimodal data;Multimodal Imaging;multimodal modeling;multimodality;Neuroanatomy;Neurodegenerative Disorders;neuroimaging;Noise;novel;Outcome;Patients;Performance;preservation;prevent;Research Personnel;response;Rest;San Francisco;Signal Transduction;simulation;software development;Specific qualifier value;Statistical Methods;Statistical Models;Structural Models;Structure;Subgroup;theories;tool;Uncertainty;vector;Work

PROJECT_TITLE: Bayesian Object-Oriented Modeling of Multi-Modal Imaging Data

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]