ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_DEPT: GENETICS

PHR: The introduction of clinical exome sequencing and whole genome sequencing has transformed our ability to diagnose patients with suspected genetic disease. However, up to 70% of patients with suspected genetic disease remain undiagnosed likely because their disease-causing variant(s) has yet to be discovered or the clinical significance of variants identified in genomic studies remains unclear. The BCM Center for Precision Medicine Modeling will support local, national, and international programs and individual researchers in the development of precision animal models that end the diagnostic odyssey of patients with undiagnosed, rare, and Mendelian diseases and serve as resources for pre-clinical studies investigating personalized medicine approaches to their care.

PI_NAMEs: BURRAGE, LINDSAY C;HEANEY, JASON D. (contact);MILOSAVLJEVIC, ALEKSANDAR

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Affect;Animal Model;Back;Bioinformatics;Body System;Caring;Clinical;clinical care;clinical diagnostics;Clinical Research;Clinical Trials;clinically significant;Collaborations;college;Communities;Databases;design;Development;Diagnosis;Diagnostic;Disease;disease model;disease-causing mutation;DNA lesion;Drosophila melanogaster;exome sequencing;fly;gene discovery;Genes;Genetic Diseases;genetic disorder diagnosis;Genome;genome sequencing;Genomics;Goals;House mice;Human Genetics;Human Genome;Individual;Infrastructure;International;Leadership;Medical Genetics;Medicine;Mendelian disorder;metabolomics;model organism;Modeling;Modification;Molecular;Molecular Genetics;multidisciplinary;Mus;nonhuman primate;Patient Care;Patients;personalized approach;personalized medicine;Phenotype;precision medicine;preclinical study;Production;programs;Provider;Rare Diseases;recruit;Reporting;Research Personnel;Resources;Structure;Study models;Techniques;Technology;therapeutic evaluation;tool;transcriptome sequencing;Translating;translational impact;translational study;Translations;Variant;variant of unknown significance;Vision;whole genome

PROJECT_TITLE: BCM Center for Precision Medicine Models


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Heart Disease;Lung;Pulmonary Hypertension;Rare Diseases

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Pulmonary arterial hypertension (PAH) is a complex disease with high mortality and morbidity, especially when the right ventricle (RV) fails. This project will explore the proteomic signatures associated with phenotypes of RV failure and PAH mortality and understand the pathways that link metabolic and protein changes in these disease processes. The completion of this study will suggest molecular mechanisms of right ventricular adaptation and guide future research on therapeutic targets for right heart failure.

PI_NAMEs: PI, HONGYANG  (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Big Data;Bioinformatics;Biological;Biological Factors;Biological Process;Biometry;Blood Vessels;Brain natriuretic peptide;candidate identification;career;Clinical;cohort;Complement;Complex;Data;data integration;Dedications;Dimensions;Disease;Etiology;Event;experience;Foundations;Functional disorder;Funding;Goals;Heart;Heart failure;Heterogeneity;Histidine;Histidine Metabolism Pathway;Individual;insight;K-Series Research Career Programs;Left;Life;Link;Lung;Machine Learning;Maps;Master of Science;Mediating;Mentors;Mentorship;Metabolic;Metabolic Marker;Metabolic Pathway;metabolic profile;Metabolism;metabolome;metabolomics;Methodology;Methods;Molecular;Morbidity - disease rate;mortality;multidimensional data;multiple omics;N-terminal;National Heart, Lung, and Blood Institute;novel;Outcome;Participant;Pathway interactions;Patients;Phenotype;Plasma;Polyamines;Process;prognosis biomarker;Progressive Disease;prospective;protein biomarkers;Proteins;Proteome;proteomic signature;Proteomics;pulmonary arterial hypertension;Pulmonary Heart Disease;Pulmonary Hypertension;pulmonary vascular disorder;Pulmonary Vascular Resistance;randomized trial;Research;Right Ventricular Dysfunction;right ventricular failure;Right ventricular structure;Severities;Signal Transduction;skills;Solid;Sphingomyelins;Systems Biology;targeted treatment;therapeutic target;Tissues;tool;Training Programs;Translational Research;Universities;Vascular remodeling;Ventricular;Washington;Work

PROJECT_TITLE: Proteomic Signatures Associated with Right Ventricular Failure and Mortality in Pulmonary Arterial Hypertension


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT 4: PROJECT NARRATIVE Glioblastoma (GBM) is the most common and lethal brain tumor due to its aggressiveness and ability to resist conventional radio- and chemotherapy. Elucidating the mechanism of chemoresistance is vital to developing an effective therapeutic intervention. This project proposes conducting a Phase 1 clinical trial of mycophenolate mofetil (MMF), an FDA-approved drug from the organ-transplant setting, in combination with standard chemo and radiotherapy for newly diagnosed patients with GBM.

PI_NAMEs: AHMED, ATIQUE U. (contact)

PROJECT_TERMS: Accountability;Adjuvant;ADP-Ribosylation Factors;Aftercare;Amino Acids;Anabolism;arm;Biogenesis;Biological Markers;biomarker identification;Blood;Brain Neoplasms;cancer cell;cancer initiation;Cell division;cell type;Cells;Central Nervous System;Characteristics;Chemoresistance;chemotherapy;Cilia;Clinical;clinical translation;clinical trial protocol;Combined Modality Therapy;CRISPR screen;Data;Diagnosis;DNA;DNA Damage;Dose;effective therapy;Effectiveness;Eligibility Determination;Enrollment;enzyme biosynthesis;Enzymes;Epigenetic Process;Evaluation;Excision;EZH2 gene;FDA approved;fitness;gene network;Genes;genome-wide;Glioblastoma;Goals;High Pressure Liquid Chromatography;improved;In Vitro;in vivo;Inosine Monophosphate;Institutional Review Boards;knock-down;Laboratories;Maintenance;Malignant neoplasm of brain;Malignant Neoplasms;Maximum Tolerated Dose;Mediating;member;Metabolic;metabolomics;Methods;Molecular;Monitor;mouse model;mycophenolate mofetil;Mycophenolic Acid;Newly Diagnosed;Normal Cell;novel;nucleotide metabolism;Operative Surgical Procedures;Organ Transplantation;overexpression;Oxidoreductase;Pathway interactions;patient derived xenograft model;patient population;patient prognosis;Patient-Focused Outcomes;Patients;Peripheral;Pharmaceutical Preparations;Phase;Phase 1/1b Clinical Trial;Phase I Clinical Trials;Polycomb;predict clinical outcome;predictive marker;Predisposition;prevent;Primary Brain Neoplasms;primary endpoint;Prognosis;Property;Protein Family;Proteins;Protocols documentation;purine metabolism;Purines;Radiation therapy;Recommendation;Recurrence;Recurrent tumor;Recycling;Repressor Proteins;Resistance;Ribonucleotide Reductase;RNA;RRM2 gene;Safety;secondary endpoint;Slide;small molecule;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;standard care;standard of care;Stress;System;temozolomide;Therapeutic;Therapeutic Intervention;therapeutically effective;therapy resistant;Tissues;Toxic effect;transcriptomics;translational approach;Treatment Efficacy;treatment response;tumor;Tumor Tissue;Validation;Work;Xenograft Model

PROJECT_TITLE: A Phase 1 Adaptive Dose Escalation Study of Mycophenolate Mofetil in Combination with Temozolomide for Patients with Newly Diagnosed Glioblastoma


ADMINISTERING_IC: HG

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Neurosciences;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: SANTA CRUZ

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

ORG_STATE: CA

PHR: Project Narrative We will introduce a new experimental platform paradigm to genomic studies of live cells and tissues that will allow scientists to be more creative, more productive, more collaborative and use fewer resources for their live cell genomics experiments. We will create new platforms that provide living cells growing in realistic 3D cultures that mimic actual tissues in the body and incorporate Internet-based remote control and analysis capabilities. We will deploy this technology to perform new, more robust and more reproducible experiments leading to discoveries in neurodevelopmental disease and cancer.

PI_NAMEs: HAUSSLER, DAVID H (contact);SALAMA, SOFIE REDA;SCHMIDT, HOLGER

PROGRAM_OFFICER_NAME: MORRIS, STEPHANIE A

PROJECT_TERMS: 3-Dimensional;3D Print;Address;anti-cancer research;Area;base;Biological Assay;Biopsy;Bioreactors;Blood;Brain;Brain Injuries;Cancer Patient;Cell Culture Techniques;Cell Line;cell type;Cells;Cellular biology;Cellular Phone;Cerebrum;Childhood Glioma;Clinical Data;Clustered Regularly Interspaced Short Palindromic Repeats;Code;cohort;Communities;community college;Competence;Complementary DNA;Computer software;Computers;cost;Creativeness;CRISPR interference;CRISPR-mediated transcriptional activation;Data;Data Analyses;Data Set;data sharing;Democracy;design;Development;Devices;Disadvantaged;Disease;disease model;doctoral student;driver mutation;Drug Screening;Ecosystem;Education;education access;Education and Outreach;Educational workshop;Electrodes;empowerment;engineered stem cells;Ensure;Environment;Evolution;exosome;experimental study;fabrication;Feedback;flexibility;General Population;Genes;genome sciences;Genomic approach;genomic data;Genomic Data Commons;Genomics;Genotype;Geometry;glioma cell line;graduate student;Growth;Human;Hydrogels;Image;improved;Incubators;Individual;innovation;Institution;Intercellular Fluid;interest;International;Internet;Internet of Things;Laboratories;Link;Machine Learning;Maintenance;Malignant Childhood Neoplasm;Malignant Neoplasms;Maps;Membrane Potentials;Mentorship;Methodology;Microfluidics;Microscopy;Modeling;Molds;Molecular;Monitor;Morphology;nanopore;National Human Genome Research Institute;Nervous System Disorder;neural circuit;Neurobiology;neurodevelopment;Neurodevelopmental Disorder;Neurosciences Research;new technology;next generation;novel strategies;online community;online resource;open source;Operative Surgical Procedures;optogenetics;Organoids;outreach;Pathogenesis;Pathway interactions;Patients;Pattern;pedagogy;Pediatric Oncology;Performance;Perfusion;petabyte;Phenotype;Pongidae;Postdoctoral Fellow;pre-clinical;precision oncology;Printing;Productivity;programs;Proteins;remote control;Reporter;Reproducibility;Research;Research Personnel;Resolution;Resources;response;RNA;scaffold;Schools;Science;Scientist;screening;Secondary Schools;sensor;Speed;stem cells;stroke model;student training;System;Techniques;Technology;Testing;Therapeutic;three dimensional cell culture;tissue culture;Tissue Model;tissue/cell culture;Tissues;Training;Training Programs;transcriptomics;tumor;undergraduate student;Universities;Variant;Vascularization;Venous;webinar;Work

PROJECT_TITLE: Center for Live Cell Genomics


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Cerebrovascular;Lymphatic Research;Neurosciences;Sleep Research

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PI_NAMEs: NEDERGAARD, MAIKEN  (contact)

PROJECT_TERMS: Affinity;Albumins;Animals;Arousal;arteriole;Astrocytes;Automobile Driving;awake;Binding;Biological Assay;Blood;Blood flow;Blood Vessels;Blood Volume;Brain;Cells;Compensation;Cranial Nerves;Cyclic AMP;Dependence;Diameter;Dimensions;Electroencephalography;fluid flow;G-Protein-Coupled Receptors;Genetic;Glial Fibrillary Acidic Protein;Global Change;glymphatic clearance;glymphatic flow;glymphatic system;Human;Hyperemia;Image;Individual;Injections;Ketamine;Kidney;Kinetics;Link;Liquid substance;Literature;Lymphatic;Maps;Measurement;Measures;Mechanics;Microspheres;Modeling;Monitor;Mus;neural;neural circuit;Neural Interconnection;neural patterning;neuroimaging;Neurons;neurovascular coupling;neurovascular unit;non rapid eye movement;novel;Optics;optogenetics;particle;Penetration;pharmacologic;physical property;Play;Population;Population Control;Process;Property;Pump;Pupil;Regulation;Resolution;response;Role;Route;Scanning;Sedation procedure;Sensory;Signal Transduction;Sleep;Smooth Muscle Myocytes;solute;Source;spatiotemporal;Testing;Tracer;two-photon;Vascular Smooth Muscle;Venous;Vibrissae;wasting;Work;Xylazine

PROJECT_TITLE: Project 2: Periarterial CSF pumping: Dependence on state of brain activity


PI_NAMEs: DREW, PATRICK JAMES (contact)

PROJECT_TERMS: Area;Arteries;Astrocytes;awake;basal forebrain;Biosensor;Blood Vessels;Blood Volume;Brain;Calcium Signaling;cell type;Cerebrospinal Fluid;cerebrospinal fluid flow;cholinergic;comparative;Complement;constriction;Cortical vasculature;Data;Diameter;Electroencephalography;experimental study;Fiber;fluorescence imaging;Genetic;Goals;hemodynamics;hippocampal pyramidal neuron;Human;Image;Link;Liquid substance;locus ceruleus structure;Measurement;Measures;Microscopic;Microspheres;Modeling;Motion;mouse model;Movement;Mus;neural;neural circuit;Neuroglia;neuroimaging;neuromechanism;Neurons;neuroregulation;neurovascular coupling;neurovascular unit;Nitric Oxide Synthase Type I;non rapid eye movement;noradrenergic;optical imaging;optogenetics;Parvalbumins;Pattern;Photometry;Population;Pump;response;Role;Sensory;Signal Transduction;Sleep;solute;Somatostatin;spatiotemporal;Speed;Testing;tool;Transgenic Mice;two photon microscopy;two-photon;Vascular Smooth Muscle;vasoconstriction;Vasodilation;Visualization;Work

PROJECT_TITLE: Project 3: Dissecting the neural and neuromodulatory control mechanisms of arterial dynamics during sleep


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Obesity

ORG_CITY: Aurora

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative There is a critical need to train new investigators to continue the scientific advances that have helped address the health consequences of obesity and type 2 diabetes. The proposed new Research Training Program in Metabolism, Obesity and Type 2 Diabetes will leverage the skills of a group of talented, experienced and well- funded mentors with the state of the art facilities and programs at the University of Colorado Anschutz Medical Center and a robust pipeline of outstanding MD, MD/PhD and PhD’s candidates to train the next generation of independent academic researchers addressing these important public health challenges.

PI_NAMEs: BESSESEN, DANIEL HOLLAND (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Metabolism;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Research Training;Training Programs

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Neurosciences;Sleep Research

PI_NAMEs: LEWIS, LAURA DIANE (contact)

PROJECT_TERMS: Acetylcholine;Anterior;Arousal;Automobile Driving;basal forebrain;Behavioral;Blood Vessels;Brain;Brain imaging;brain shape;Cell Nucleus;Cerebrospinal Fluid;cerebrospinal fluid flow;Collaborations;Common Data Element;Coupled;Electroencephalography;Electrophysiology (science);fluid flow;Frequencies;Functional Magnetic Resonance Imaging;Goals;hemodynamics;Human;Image;Imaging Techniques;Link;Liquid substance;locus ceruleus structure;Magnetic Resonance Imaging;Maps;Measurement;Measures;Modeling;Multimodal Imaging;Mus;neural;neural circuit;neural patterning;neuromechanism;Neuromodulator;Neurons;neuroregulation;neurovascular coupling;non rapid eye movement;Norepinephrine;novel;Pattern;Play;predictive modeling;Property;Resolution;response;Role;Sensory;Shapes;Signal Transduction;Sleep;Sleep Stages;solute;spatiotemporal;Specific qualifier value;Stimulus;Subarachnoid Space;Techniques;Technology;Testing;Theoretical model;Translating;Travel;Update;Visual;visual stimulus;Wakefulness

PROJECT_TITLE: Project 4: Linking neural, hemodynamic, and multiscale cerebrospinal fluid flow measures in humans


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative Drugs of abuse, like opioids, hijack brain circuits that govern adaptive motivation and decision making, yet the identity and function of such circuits remains largely unresolved. Gaining a deeper understanding of how such circuits generate both healthy and unhealthy motivation will greatly enhance our ability to target and treat those brain regions rendered pathological in psychiatric disorders like addiction. Here, I use gene transfer approaches and circuit manipulations to determine functions of the ventral pallidum in risky decision making, and seeking of addictive opioid drugs.

PI_NAMEs: FARRELL, MITCHELL  (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Abstinence;Acute;addiction;Address;adverse outcome;Animal Model;Attention;Attenuated;Award;Behavior;Behavior Control;Behavioral;Behavioral Model;Brain;Brain region;career;cell type;Cells;Cocaine;cocaine exposure;cocaine relapse;cocaine seeking;Cognition;cost;Coupled;Cue-induced relapse;Cues;Data;Decision Making;Dedications;designer receptors exclusively activated by designer drugs;Development;Disease;Doctor of Philosophy;Drug Addiction;drug of abuse;drug reward;Drug usage;Educational process of instructing;Educational workshop;effective therapy;Electrophysiology (science);Environment;Exhibits;Faculty;Fellowship;fentanyl analog;Food;footshock induced;Funding;gamma-Aminobutyric Acid;Gene Transfer;Genetic;genetic approach;genetic manipulation;Globus Pallidus;Goals;Grant;Hand;Health;human model;Image;in vivo;Individual;individual variation;Learning;Mediating;Mental disorders;Mentors;Mentorship;model design;Modeling;Monitor;motivated behavior;Motivation;National Institute of Drug Abuse;neural circuit;Neurons;Neurosciences;Neurotransmitters;Opiate Addiction;Opioid;opioid epidemic;Outcome;Paper;Pathologic;Pathway interactions;Persons;Pharmaceutical Preparations;pharmacologic;Phase;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;pre-clinical;pre-doctoral;Predisposition;Preparation;Procedures;Process;professor;programs;Protocols documentation;Published Comment;Publishing;Punishment;Rattus;Relapse;remifentanil;Research;Resources;Rest;Rewards;Risk;Rodent Model;Role;Scientist;Self Administration;Shock;skills;Substance Use Disorder;Symptoms;Techniques;tenure track;Testing;therapeutic target;Time;Training;training opportunity;Universities;Ventral Tegmental Area;Work

PROJECT_TITLE: Ventral Pallidum Circuits in Motivation, Risky Decision Making, and Opioid Addiction


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Neurosciences;Rare Diseases

PHR: BIOSPECIMEN CORE: NARRATIVE The Biospecimen Core will serve as source of patient tumor and normal tissues to meet the needs of the individual projects. The Core also generates its own biospecimen-based research pertaining to brain tumors, and will provide all tissue and tumor model analytical services that are needed to advance SPORE laboratory and clinical research.

PI_NAMEs: HORBINSKI, CRAIG MICHAEL (contact)

PROJECT_TERMS: associated symptom;Autopsy;Bioinformatics;Biological Assay;Biological Markers;Biological Specimen Banks;Biometry;Blood;Blood specimen;Brain Neoplasms;Brain Stem;Caring;Cells;chemotherapy;Clinical;clinical diagnostics;Clinical Research;clinical translation;Clinical Trials;clinically relevant;Collection;common symptom;Consent;Consultations;Copy Number Polymorphism;Data;Databases;Diagnostic tests;Dimensions;DNA;efficacy evaluation;Electronics;end of life;Ensure;Equipment and supply inventories;Evaluation;experience;follow-up;Freezing;Funding;Genes;Glioma;high risk;Histologic;Individual;Infiltration;Institution;interest;Investigation;Ischemia;Laboratory Research;Malignant neoplasm of brain;meningioma;Microsatellite Instability;Microscopy;Modeling;Molecular;Mutation;neuropathology;Neurosphere;next generation sequencing;Normal tissue morphology;Operating Rooms;Operative Surgical Procedures;Outcome;Paraffin Embedding;Pathologic;patient derived xenograft model;Patients;Pattern;Peripheral Blood Mononuclear Cell;Phase;Plasma;Productivity;Promega;Protocols documentation;Quality Control;repository;Research;Research Personnel;Research Project Grants;Research Support;Resources;RNA;Sampling;Secure;Serum;Services;Short Tandem Repeat;Site;Source;Specimen;Supratentorial;sustainable resource;Testing;Time;Tissue Sample;Tissues;translational approach;Treatment Efficacy;tumor;Tumor Biology;Tumor Tissue;Universities

PROJECT_TITLE: Biospecimen Core


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: BOSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TUFTS UNIVERSITY BOSTON

ORG_STATE: MA

PHR: Project Narrative (Public Health Significance) There is a paucity of research examining the intersection of race, ethnicity, maternal safety bundles, doulas, and maternal outcome in Black women at increased risk of severe maternal morbidity and mortality. The proposed mixed-methods study is the first systematic investigation of pregnancy complications and outcomes among Black women with whom maternal safety bundles including racial disparities, hemorrhage, and hypertension have been utilized and through the analysis of secondary state level data, this study will examine perinatal care, maternal outcomes, and healthcare utilization of Black women at increased risk of severe maternal morbidity and mortality compared with non-Latino white women. Additionally, through individual interviews with Black women and focus groups with obstetric health providers and doulas, the study will examine disparities and improve care by creating and disseminating a set of practice recommendations for maternity care for Black women at increased risk of morbidity and mortality.

PI_NAMEs: AMUTAH-ONUKAGHA, NDIDIAMAKA  (contact);DECLERCQ, EUGENE R;DIOP, HAFSATOU

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: Address;Area;Attitude;Biological;Birth;Black Populations;black women;Caring;Centers for Disease Control and Prevention (U.S.);Color;Communities;Conceptions;Data;Data Collection;Data Linkages;Data Sources;Death Rate;design;Development;Discipline of obstetrics;Disparate;Disparity;disparity gap;disparity reduction;effectiveness evaluation;ethnic minority;Ethnic Origin;Ethnic Population;experience;Focus Groups;Foundations;Future;Health;health care service utilization;health disparity;health inequalities;Health Personnel;Hemorrhage;High Prevalence;High Risk Woman;Hispanic Women;Hospitalization;Hospitals;hybrid type 1 trial;Hypertension;implementation evaluation;implementation framework;implementation outcomes;implementation process;implementation science;improved;improved outcome;Individual;Inequity;Information Systems;innovation;integrated care;Intervention;Interview;Investigation;Life;Link;Live Birth;longitudinal design;Massachusetts;Maternal Health;Maternal Mortality;maternal outcome;maternal safety;Medical Care Team;Methods;Modeling;Morbidity - disease rate;mortality;Mothers;National Institute on Minority Health and Health Disparities;Not Hispanic or Latino;obstetric care;Outcome;Pattern;peer;Perinatal Care;Population;post-COVID-19;postpartum care;Postpartum Period;practice setting;Pregnancy;Pregnancy Complications;Pregnancy Outcome;prenatal;Prenatal care;prevent;preventable death;programs;Provider;Public Health;Race;racial disparity;racial minority;racial population;Recommendation;Reporting;Research;Review Committee;Risk;scale up;secondary analysis;Services;severe maternal morbidity;System;Testing;tool;United States;White Women;Woman;Women's Group;Women's Health

PROJECT_TITLE: Reducing Racial Disparities in SMM post COVID19: Assessing the integration of maternal safety bundles and community based doulas to improve outcomes for Black women


NIH_SPENDING_CATS: Genetics;Precision Medicine

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PI_NAMEs: HEANEY, JASON D. (contact)

PROJECT_TERMS: Animal Model;Area;Bioinformatics;Biomedical Research;Caring;Communication;Communities;Data Reporting;Development;Diagnostic;Electronics;Ensure;experience;Funding;genetic variant;Goals;Governing Board;Grant;Human;human disease;Individual;International;Lead;Leadership;Measures;Medical Genetics;meetings;member;Mendelian disorder;model organism;Modeling;Molecular Genetics;Monitor;multidisciplinary;operation;organizational structure;outreach;Patients;personalized medicine;Phenotype;precision medicine;preclinical study;Procedures;Production;programs;Publications;Rare Diseases;recruit;Reporting;Research;Research Personnel;Resources;Schedule;Services;Site Visit;tool;United States National Institutes of Health;Variant;web site;Work;working group

PROJECT_TITLE: Coordination Section

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMST-U]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease

ORG_CITY: Columbus

ORG_DEPT: PHYSIOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE As the leading cause of morbidity and mortality in the world, heart disease is a critical problem. The proposed study will investigate the novel roles of a protein named YTHDF3 in the regulation of heart function. This work will improve our understanding of how heart muscle cells maintain their health, guiding the way for the development of new treatments for heart failure.

PI_NAMEs: RABOLLI, CHARLES P. (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Address;Adenosine;Adopted;Adult;Affect;aorta constriction;Binding;Binding Proteins;biological adaptation to stress;Biology;Cardiac;Cardiac Myocytes;Cause of Death;Cell Nucleus;Chemicals;Co-Immunoprecipitations;coping mechanism;crosslink;Data;Development;Dilated Cardiomyopathy;Disease;Drug Design;Echocardiography;Enhancers;Enzymes;epitranscriptome;Eukaryota;Event;experimental study;Family;Functional disorder;Future;Gene Expression;Gene Expression Regulation;Genetic Transcription;Growth;Health;Heart;Heart Diseases;Heart failure;heart function;Heart Hypertrophy;Heart Injuries;Histologic;Homeostasis;Hypertrophy;Immunoprecipitation;improved;improved outcome;Injury;innovation;Knock-out;Knockout Mice;Knowledge;Mass Spectrum Analysis;Mediating;member;Messenger RNA;Methylation;Modeling;Modification;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Muscle Cells;Myocardial;Names;novel;novel therapeutics;Nuclear;Pathologic;Pathology;Patients;Phenotype;Physiological;Positioning Attribute;posttranscriptional;pressure;Property;protein protein interaction;Proteins;Proteome;Reader;Regulation;Research;Research Personnel;response;RNA;RNA Binding;RNA methylation;RNA-Binding Proteins;Role;Stress;Testing;Therapeutic;Time;Transcript;transcription factor;transcriptome sequencing;Translations;Work;Workload

PROJECT_TITLE: YTHDF3 as a critical regulator of cardiac function


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Precision Medicine

PI_NAMEs: BURRAGE, LINDSAY C (contact)

PROJECT_TERMS: Adult;Animal Model;Back;biomarker discovery;Childhood;Clinical;clinical care;clinical diagnostics;Clinical Research;clinical research site;Clinical Trials;clinically significant;Collaborations;Communities;cost;Data;Databases;Diagnosis;Diagnostic;Diet;Disease;disease-causing mutation;DNA lesion;DNA Sequencing Facility;Drosophila melanogaster;drug repurposing;Drug Screening;empowerment;Evaluation;exome sequencing;Family;fly;gene discovery;Genes;Genetic;Genetic Counseling;Genetic Diseases;genetic disorder diagnosis;Genome;genome sequencing;Genomic medicine;Genomics;Genotype;House mice;human disease;human genome sequencing;human model;Individual;Infrastructure;Laboratories;Laboratory mice;Medical Records;metabolomics;model organism;Modeling;Modification;Molecular;mRNA sequencing;Mus;network models;new technology;nonhuman primate;novel therapeutics;Nutritional;Participant;Patients;personalized approach;personalized medicine;Phenotype;Play;pre-clinical;precision medicine;prenatal;Preventive Medicine;programs;Provider;Research;Research Infrastructure;Research Personnel;Resources;Role;Scientist;screening;Site;Structure;success;Technology;Therapeutic;Therapeutic Agents;Time;tool;Translating;translational impact;Translational Research;Translations;Variant;Vitamins;whole genome

PROJECT_TITLE: Preclinical/Co-Clinical Section


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease

ORG_CITY: SAINT LOUIS

ORG_DEPT: SURGERY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative This study will attempt to understand how in patients with a diseased heart valve, the altered blood flow causes changes in the atria and ventricles that makes them more likely to develop an irregular rhythm such as atrial fibrillation or premature ventricular contractions. Understanding these mechanisms will help provide a rationale for determining the appropriate timing of valve surgery. It will also help to decide which patients need treatment such as ablation of their atrial and ventricular irregular rhythms.

PI_NAMEs: DAMIANO, RALPH J (contact);ZEMLIN, CHRISTIAN W

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: Ablation;Address;Anatomy;Animal Model;Animals;Area;Arrhythmia;Atrial Fibrillation;auricular appendage;Biopsy;Blood flow;canine model;Canis familiaris;Cardiac;Chest;Chronic;Clinical;clinical phenotype;clinical practice;Cohort Studies;Control Animal;Data;Decision Making;Development;Disease;Echocardiography;Electrocardiogram;Electrophysiology (science);Etiology;Evolution;Exhibits;Fiber;Fibrosis;Goals;Grant;Heart;Heart Atrium;Heart Valve Diseases;Image;Imaging Device;immune cell infiltrate;Immune response;Immunologics;in vivo;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Intervention;Laboratories;Left;Left atrial structure;Left ventricular structure;Leucocytic infiltrate;Location;Magnetic Resonance Imaging;Maps;Mediating;minimally invasive;Mitral Valve;Mitral Valve Insufficiency;Modeling;mortality;multimodality;non-invasive imaging;novel therapeutic intervention;Nuclear RNA;operation;Operative Surgical Procedures;Optics;papillary muscle;Pathway interactions;Patients;Pattern;Play;prospective;randomized trial;response;Risk;RNA analysis;Role;Shunt Device;Sinus;Slice;sudden cardiac death;Thinness;Time;Tissues;Ventricular;Ventricular Arrhythmia;Ventricular Premature Complexes;Ventricular Remodeling;young woman

PROJECT_TITLE: Surgical Treatment of Cardiac Arrhythmias

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Genetics;Human Genome;Precision Medicine

PI_NAMEs: MILOSAVLJEVIC, ALEKSANDAR  (contact)

PROJECT_TERMS: Animal Model;Back;Bioinformatics;bioinformatics infrastructure;Biological Assay;Clinical;Communities;community engagement;Data;data integration;data modeling;data portal;digital;disease model;Elements;Engineering;Evaluation;experience;experimental study;fly;Genes;Genetic;genetic manipulation;genetic variant;genome repository;genome sequencing;Human;human disease;Informatics;information model;Infrastructure;insight;interest;Internet;Knowledge;Laboratory Organism;Link;model organism;Modeling;Molecular;Multiomic Data;Phenotype;pre-clinical;precision medicine;Process;Production;prospective;Publications;Qualifying;Reporting;repository;Research Personnel;Resources;Role;screening;Services;System;Technology;Testing;tool;Variant;variant of interest;web portal;web site

PROJECT_TITLE: Bioinformatics Section


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Rare Diseases

PHR: BIOSTATISTICS AND BIOINFORMATICS CORE: NARRATIVE The Biostatistics and Bioinformatics Core (B&B) Core has three primary responsibilities: 1) development and maintenance of preclinical and clinical database functionality to support all Brain Tumor SPORE Projects; 2) application of bioinformatics pipelines for pre-processing and analysis of high-dimensional omics data to identify novel and significant avenues of research for all four Brain Tumor SPORE projects; and 3) biostatistical contribution to study design, data analysis and interpretation of results for all preclinical and clinical Brain Tumor SPORE Projects to ensure that all reported program accomplishments undergo rigorous evaluation.

PI_NAMEs: ZHANG, HUI  (contact)

PROJECT_TERMS: Adherence;Bioinformatics;bioinformatics pipeline;Biological;Biometry;Brain;Brain Neoplasms;Cells;Characteristics;Clinical;Clinical Data;clinical database;Clinical Research;clinical trial participant;Clinical Trials;Code;Collaborations;Complement;complex data;Comprehensive Cancer Center;Consultations;Custom;Data;Data Analyses;Data Collection;data integration;data management;data registry;data resource;Data Science;Data Set;data standards;Data Storage and Retrieval;Databases;Dedications;design;Development;electronic data;Ensure;Environment;Evaluation;Experimental Designs;experimental study;Fostering;genetic manipulation;Guidelines;high dimensionality;improved;Individual;Investigation;Maintenance;Malignant neoplasm of brain;medical schools;member;Modification;Molecular;Monitor;Monitoring Clinical Trials;novel;Output;Patient Care;patient safety;Patients;pre-clinical;preclinical study;programs;Protocols documentation;Registries;Reporting;Reproducibility;Reproduction spores;Research;Research Design;Research Support;Safety;Secure;Statistical Data Interpretation;Tissues;translational approach;tumor

PROJECT_TITLE: Biostatistics and Bioinformatics Core


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: PORTLAND

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative: Public Health Relevance Hearing loss is a major health problem that significantly affects the life quality of affected individuals. Many forms of hearing loss are genetic in origin and affect hair cells, the mechanosensors that convert sound induced vibrations into electrical signals. We propose here to show how the critical mechanosensitive structure of the hair cell is assembled, and how specific genes control that assembly. This information may eventually help guide therapeutic approaches leading to hearing restoration.

PI_NAMEs: BARR-GILLESPIE, PETER GORDON (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: 3-Dimensional;Abbreviations;Actins;Affect;Age;aspirate;Auditory system;Biological Assay;Biological Models;Cell Separation;Cells;Characteristics;Chick;Cochlea;Complex;Coupled;Cryo-electron tomography;Data;deafness;detection sensitivity;Development;Diameter;Dimensions;Electron Microscopy;Epidermal Growth Factor Receptor Pathway Substrate 8;Event;experimental study;Fluorescence-Activated Cell Sorting;Genes;Genetic;GNAI3 gene;Goals;GPSM2 gene;Growth;Guide RNA;Hair;Hair Cells;Health;hearing impairment;hearing restoration;hereditary hearing loss;hydrodynamic flow;Image;Immunoprecipitation;Individual;Inner Hair Cells;Laboratories;Length;Ligation;Location;Mass Spectrum Analysis;Measures;mechanical force;mechanotransduction;Methods;Microfilaments;Microscope;Modality;Modeling;Molecular;Mus;mutant;Mutant Strains Mice;Mutation;nanoDroplet;nanoscale;neuronal cell body;Organelles;Outer Hair Cells;Pacific Northwest;Peripheral;Process;programs;protein expression;Protein Isoforms;protein transport;Proteins;Proteome;Proteomics;public health relevance;Quality of life;Resolution;Sampling;Sensory;Signal Transduction;single-cell RNA sequencing;sound;Structure;Techniques;Testing;Therapeutic;Thick;Thinness;Time;tomography;tool;transcriptome;transcriptome sequencing;vibration;WHRN gene;Width;Wild Type Mouse

PROJECT_TITLE: Hair Bundle Structure and Dynamics


PI_NAMEs: SEAVITT, JOHN RICHARD (contact)

PROJECT_TERMS: Address;Affect;Alleles;animal breeding;Animal Experiments;Animal Model;animal resource;Animal Testing;Applications Grants;Archives;Area;Bioinformatics;Clinic;Communication;Communities;Community Outreach;cost;Data Analyses;Disease;disease model;Drosophila genus;Ensure;Environment;Fee-for-Service Plans;fly;gene discovery;Genetic Engineering;Genetic Identity;Genetic Variation;genome editing;genome integrity;Goals;Health Services Accessibility;Heart;human disease;human genome sequencing;Infrastructure;instrumentation;Knockout Mice;Leadership;Link;Macaca mulatta;Maintenance;meetings;Methods;model organism;Modeling;Mus;network models;news;operation;Patient risk;Patients;Phenotype;precision medicine;preclinical study;preservation;Preservation Technique;Procedures;Process;Production;programs;public repository;Publishing;quality assurance;Reproducibility;Research;Research Design;Research Personnel;Resources;Rice;Risk Assessment;Sample Size;screening;Services;Site;social media;somatic cell gene editing;Standardization;Statistical Methods;Structure;Technology;Text;Translations;web site

PROJECT_TITLE: Resource and Service Center


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Pediatric;Precision Medicine;Rare Diseases

PROJECT_TERMS: 17q12;Adult;Affect;Age of Onset;Alleles;Animal Model;Animals;Ataxia;Atrophic;AXIN2 gene;Back;beta catenin;Bioinformatics;Biological Markers;Body System;Brain imaging;Calcium Channel;Calcium Channel Blockers;Choanal Atresia;Clinical;clinically relevant;Coloboma;Colorectal Cancer;Complex;craniofacial;Data;data access;Data Collection;data submission;Defect;Development;Diabetes Mellitus;diabetes risk;Disease;disease model;Dominant-Negative Mutation;Dysplasia;Early Intervention;early onset;Embryo;fly;gain of function;Genes;Genetic;genome editing;Glucose;Glucose Intolerance;Goals;Hair;Haplotypes;Heterozygote;human disease;Hypodontia;Image;Individual;Infant;informatics infrastructure;Insulin;interest;Intervention;Intervention Studies;Islet Cell;Islets of Langerhans;Kidney;Knock-in;Knock-in Mouse;Knockout Mice;Limb structure;loss of function;Loss of Heterozygosity;Macaca mulatta;maturity onset diabetes of the young;Microphthalmos;model organism;Modeling;Modification;Motor;mouse model;Mus;neurobehavior;neurobehavioral;Neurologic;Neurons;novel therapeutic intervention;Onset of illness;Patient Care;Patients;Pharmaceutical Preparations;Phenotype;Play;pre-clinical;precision medicine;Process;Production;programs;Rare Diseases;Recurrence;Resources;Risk;Role;Services;Severities;SHFM1 gene;Signal Transduction;Syndrome;Techniques;Testing;Therapeutic;transcriptome;Translating;translational impact;translational potential;treatment optimization;Variant;variant of interest;voltage;WNT Signaling Pathway;Work

PROJECT_TITLE: Disease Modeling Unit


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: Chicago

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative  The proposed research utilizes a new and technically innovative approach that provides a unique window into the biophysical and morphological bases for variations in the modes of synaptic transmission between vestibular sensory hair cell receptors and their afferent and efferent endings. This research will advance our understanding of the biological bases for dizziness, vertigo, imbalance, and vestibulo-autonomic disorders due to peripheral vestibular dysfunction and will provide a clear direction for future efforts addressing treatment for these disorders.

PI_NAMEs: ART, JONATHAN JAMES (contact);HOLSTEIN, GAY R

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: 3-Dimensional;Address;AMPA Receptors;Anatomy;Area;Autonomic nervous system disorders;base;Bathing;Biological;Biophysical Process;biophysical properties;Biophysics;Calculi;Cell Separation;cell type;Cells;cholinergic;Complex;Coupling;Crista ampullaris;Disease;Distal;Dizziness;Ear;Electric Stimulation;Electrodes;Elements;Environment;Epithelium;Equilibrium;experimental study;Face;Fiber;Future;gamma-Aminobutyric Acid;Glutamates;Goals;Hair Cells;imaging study;In Situ;innovation;Ions;Kinetics;Labyrinth;Lateral;Mechanical Stimulation;Medial;Mediating;Membrane Potentials;Morphology;Muscarinics;Organ;Perilymph;Peripheral;Phase;Physiology;Positioning Attribute;postsynaptic;presynaptic;Property;Receptor Cell;regional difference;Reporting;Research;response;Role;Route;Sensory Hair;signal processing;Site;Structure;Structure of posterior semicircular canal;Synapses;Synaptic Cleft;Synaptic Transmission;System;Testing;transmission process;Turtles;Type I Hair Cell;Type II Hair Cell;Variant;Vertigo;Vestibular dysfunction;vestibular system;Visualization

PROJECT_TITLE: Synaptic Physiology of the Vestibular Periphery

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


PHR: DEVELOPMENTAL RESEARCH PROGRAM: NARRATIVE The Developmental Research Program (DRP) of the Northwestern Brain Tumor SPORE provides yearly funding for projects that have promising translational potential. DRP project investigators will be encouraged to secure independent funding in brain cancer research, or their project may replace main projects that are not progressing or that have achieved translational endpoint.

PI_NAMEs: LESNIAK, MACIEJ S (contact)

PROJECT_TERMS: anti-cancer research;Brain;Brain Neoplasms;Cancer Center;clinical application;Collaborations;Communities;Development;Diagnosis;Evaluation;experience;flexibility;Fostering;Funding;Funding Mechanisms;Institution;Malignant neoplasm of brain;Malignant Neoplasms;medical schools;minority investigator;Pilot Projects;Prevention;Probability;Process;Program Research Project Grants;programs;Research;Research Personnel;Research Project Grants;Role;Secure;Structure;translational approach;translational potential;Translational Research;United States National Institutes of Health;Universities;Woman

PROJECT_TITLE: Developmental Research Program


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: STANFORD

ORG_DEPT: DERMATOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Oncogene amplification on extrachromosomal DNA (ecDNA) is common in human cancers and drives rapid tumor evolution and poor outcomes. Despite recent advances characterizing their biology, the mechanisms by which ecDNA promotes tumor evolution are poorly understood. Through powerful combinations of new and established techniques, this project aims to elucidate how ecDNA drives tumor evolution with the goal of identifying novel therapeutic strategies.

PI_NAMEs: ROSE, JOHN CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: Advisory Committees;ATAC-seq;Automobile Driving;Award;Bar Codes;Behavior;Biogenesis;Biology;Cancer cell line;cancer therapy;Cell division;Cell Line;Cell Lineage;Cells;cellular imaging;Centromere;Chromatin;Chromatin Structure;Chromosomal Duplication;Circular DNA;Computational Biology;Coupled;CRISPR screen;CRISPR/Cas technology;Development;Dissection;DNA;Environment;epigenomics;Etiology;Evolution;experimental study;extrachromosomal DNA;Frequencies;Functional disorder;Generations;Genes;Genetic;genetic analysis;Genetic Recombination;Genetic Transcription;Genomics;Goals;Haploidy;histone modification;Hour;Human;Image;Immune Evasion;improved;insight;interest;Investigation;Link;live cell imaging;live cell microscopy;loss of function mutation;Maintenance;Malignant Neoplasms;Mentorship;Methods;micronucleus;Modeling;Molecular;Monitor;Mutation;Nature;Neoplasm Metastasis;neoplastic cell;novel;novel strategies;novel therapeutic intervention;Oncogenes;Organoids;Outcome;particle;Patients;pharmacologic;Phase;phenomenological models;Population;Postdoctoral Fellow;predictive modeling;pressure;Process;Resolution;Resources;response;Role;Sampling;segregation;small molecule;Stains;System;Techniques;theories;Therapeutic;Therapeutic Intervention;therapy resistant;Time;Tissues;Training;treatment response;tumor;tumor heterogeneity;Tumor Promotion;tumorigenesis;Universities;Work

PROJECT_TITLE: Molecular dissection of extrachromosomal DNA formation, development, and evolution

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Diabetes;Eye Disease and Disorders of Vision;Hypertension;Neurosciences;Prevention

ORG_CITY: Pasadena

ORG_NAME: DOHENY EYE INSTITUTE

PHR: Project Narrative The flow dynamics of the erythrocytes (red blood cells) inside the retinal capillaries reflects the function and the health of the retinal microcirculatory system. We will characterize the erythrocyte flow dynamics at the single retinal capillary level in the eyes of human subjects in normal health, in those with essential hypertension, and in those with diabetes, using novel adaptive optics high-speed ophthalmoscopy. This study will improve our knowledge of retinal microcirculation in normal physiological process and systemic disease and facilitate the development of novel treatment strategies for managing systemic complications of hypertension and diabetes that cause vision loss.

PI_NAMEs: ZHANG, YUHUA LIANG (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Acceleration;adaptive optics;Affect;Age;Angiography;Animal Model;Anti-Hypertensive Agents;Area;arterial stiffness;Background Diabetic Retinopathy;Biological;Biological Markers;Biological Models;Blindness;Blood capillaries;Blood Cells;Blood Circulation;Blood flow;Blood Pressure;Blood Vessels;Cardiac;cardiovascular risk factor;Cardiovascular system;Central Nervous System;Characteristics;Circadian Rhythms;Clinical;clinically significant;Complex;Development;Diabetes Mellitus;diabetic patient;Diabetic Retinopathy;Disease;Disease Progression;disorder risk;early detection biomarkers;electric impedance;Erythrocytes;Essential Hypertension;Ethnic Origin;Evaluation;Event;Excision;Eye;Functional disorder;Gender;Goals;Health;hemodynamics;Human;human subject;Hypertension;hypertensive;improved;in vivo;Individual;Intervention;Knowledge;macula;Measurement;Measures;Mechanics;Metabolic;Methods;Microcirculation;Microvascular Dysfunction;Movement;novel;Ophthalmoscopes;Ophthalmoscopy;Optical Coherence Tomography;Organ;Outcome;Oxygen;Pathology;patient population;Patients;Pharmaceutical Preparations;Physiological Processes;Play;pressure;prevent;Pulsatile Flow;Race;Resistance;response;Retina;Retinal Diseases;Risk;Risk Assessment;Role;Site;Speed;Stress;System;Systemic disease;Therapeutic Intervention;Time;Tissues;trait;Treatment Efficacy;treatment strategy;Variant;Vision;wasting

PROJECT_TITLE: In Vivo Characterizations of Retinal Hemodynamics


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: AGUADILLA

ORG_NAME: UNIVERSITY OF PUERTO RICO AT AGUADILLA

ORG_STATE: PR

PHR: Project Narrative The aim of this project is to develop and implement a surveillance system for antimicrobial resistance of enteric bacteria in retail food outlets in Puerto Rico. The Puerto Rico Antibiotic Resistance Surveillance in Retail Food Program’s primary goal is to enhance, strengthen and sustain surveillance for antibiotic resistance in retail food specimens within the National Antimicrobial Resistance Monitoring System (NARMS). Comparison of bacteria isolates recovered from retail food with strains causing human illnesses contributes to improvements in food safety, facilitates outbreak investigations, and provides data to FDA for regulatory oversight.

PI_NAMEs: MALAVEZ, YADIRA  (contact)

PROGRAM_OFFICER_NAME: YOUNG, SHENIA

PROJECT_TITLE: Puerto Rico Antibiotic Resistance Surveillance in Retail Food (PR-ARS)


PHR: CAREER ENHANCEMENT PROGRAM: PROJECT NARRATIVE The Career Enhancement Program is a critical component of the Northwestern Brain Tumor SPORE, in that it ensures that there will be a continuous influx of talented investigators devoted to brain cancer research.

PROJECT_TERMS: anti-cancer research;Award;Brain Neoplasms;career;career development;Credentialing;Dedications;Discipline;Ensure;Faculty;faculty mentor;flexibility;Future;Human;Individual;interest;Leadership;Length;Malignant neoplasm of brain;meetings;Mentors;Minority;Monitor;neuro-oncology;Process;programs;Progress Reports;recruit;Request for Applications;Research;Research Personnel;Scientist;Source;Structure;System;Talents;Training;translational approach;Woman;Writing

PROJECT_TITLE: Career Enhancement Program


ORG_NAME: MASSACHUSETTS STATE DEPT OF PUB HEALTH

PHR: PAR-20-124 NARMS Cooperative Agreement Program to Enhance and Strengthen Antibiotic Resistance Surveillance in Retail Food Specimens Massachusetts State Public Health Laboratory Project Narrative MASPHL will participate in this project by purchasing the required 33 products per month from retail locations in Massachusetts. Products will be tested for a combination of analytes as described in the provided protocols for 2022. Confirmed isolates of representative organisms from required products will be sequenced and analyzed, with analysis results shared with FDA via GenomeTrakr by PulseNet certified analysts. Isolates will be sent to FDA NARMS for antimicrobial susceptibility testing along with hard copies of electronic log sheets. Isolates will be retained on-site, along with copies of the log sheets.

PI_NAMEs: IVANOF, CARYN  (contact)

PROJECT_TITLE: MASPHL-NARMS Cooperative Agreement


ORG_CITY: CONCORD

ORG_NAME: NH STATE DEPT/HLTH STATISTICS/DATA MGMT

ORG_STATE: NH

PHR: Overall Project Narrative This cooperative agreement will enhance the capacity and capabilities of the New Hampshire Public Health Laboratory (NH PHL) in support of an integrated food safety system, with sample testing for food defense and surveillance being performed in all three areas of microbiology, chemistry, and radiochemistry. Human and animal food testing of microbiological and chemical contaminants including salmonella, pathogenic E. coli and toxic metals will be conducted using existing methods accredited by ISO 17025, and novel methods will be developed and expanded to enhance whole genome sequencing, detect cyclospora cayetanensis, allergens and radionuclides in food products. NH PHL will also enter agreements with regulatory agencies in New Hampshire for sample collection, and assist in validation of a novel method EAM 4.12 for the analysis of bottled water by ICP-MS.

PI_NAMEs: CHATTERJEE, MADHUMITA  (contact)

PROGRAM_OFFICER_NAME: WINTER, RONALD

PROJECT_TITLE: New Hampshire Laboratory Flexible Funding Model for Food Safety (LFFM)(U19)


NIH_SPENDING_CATS: Congenital Structural Anomalies;Kidney Disease;Pediatric;Polycystic Kidney Disease

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Autosomal dominant polycystic kidney disease (ADPKD) is the most common, potentially lethal, monogenic disease and is characterized by progressive cyst expansion. This project utilizes robust in vivo methodologies with a novel genetic suppression model of ADPKD to elucidate the emerging role of immune cells in cystogenesis. This proposal is relevant to public health for its potential to establish immunologic targets and signaling in ADPKD pathogenesis and identify noninvasive disease biomarkers.

PI_NAMEs: RAI, VICTORIA  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Affect;Age;Antigen-Antibody Complex;Architecture;Autosomal Dominant Polycystic Kidney;Biological Markers;C-terminal;Career Choice;CD8-Positive T-Lymphocytes;Cell Communication;cell type;Cells;Chemotactic Factors;Chronic Disease;Classification;Clonality;Communication;comparison control;Cyst;Data;Development;Dialysis procedure;Discipline;Disease;disease model;Disease Progression;Doxycycline;Educational Status;End stage renal failure;Epithelial Cells;Equipment and supply inventories;experience;Fibrosis;Flow Cytometry;Gene Expression Profile;Genes;Genetic;Genetic Suppression;Growth;Immune;immune cell infiltrate;Immune signaling;Immune Targeting;Immunofluorescence Immunologic;Immunologics;Immunology;Impaired Renal Function;in vivo;Infiltration;insight;Intervention;Investigation;Kidney;Kidney Diseases;Kidney Failure;Lead;Liquid substance;Literature;Location;Lymphoid Cell;Macrophage;Mediating;Mendelian disorder;Mentorship;Metabolic;Methodology;migration;Modeling;Monitor;Morphology;mouse model;Mus;Mutation;Myeloid Cells;Nature;novel;Outcome;Pathogenesis;Pathologic;Persons;Phenotype;Physiology;PKD1 gene;PKD2 gene;PKD2 protein;polycystic kidney disease 1 protein;Population;prevent;Prevention;Process;Proliferating;Property;Proteins;Public Health;receptor;recruit;renal epithelium;Renal function;response;Role;Signal Transduction;single cell sequencing;Site;T-Lymphocyte Subsets;Tail;Techniques;Time;Tissues;Transgenic Organisms;Transplantation;treatment strategy;Tumor Immunity;tumor metabolism;Work

PROJECT_TITLE: Immune Cell and Epithelial Cell Interactions in Autosomal Dominant Polycystic Kidney Disease


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Mental Health;Physical Activity;Prevention;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The growing burden of cardiovascular diseases among women under 60 years old is alarming; however, the unique pathophysiological risk factors causing this burden are unknown. Stress likely plays an important role in this early manifestation, potentially through reducing motivation to be physically active. This project will use data from NHLBI-funded study: Mental Stress and Myocardial Ischemia After MI: Sex Differences, Mechanisms and Prognosis (MIMS3) to investigate the role of stress and physical activity in a group of post-MI women and men to understand the importance these factors in this under-investigated population.

PI_NAMEs: SUVADA, KARA  (contact)

PROGRAM_OFFICER_NAME: PURKISER, KEVIN

PROJECT_TERMS: actigraphy;Adult;Adult women;Age Years;aged;Ambulatory Monitoring;Ancillary Study;Area;Assessment tool;Atherosclerosis;attributable risk;Automobile Driving;Autonomic nervous system;Behavioral;behavioral study;Blood Pressure;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;Cardiovascular Manifestation;cardiovascular risk factor;Cardiovascular system;career;Cause of Death;Cessation of life;clinical practice;cohort;Collaborations;Data;Decision Making;design;Disparity;Disproportionately impacts women;early onset;Elderly;emotional symptom;Enrollment;Ensure;Event;experience;Fellowship;Frequencies;Functional disorder;Funding;Future;Goals;Guidelines;Health Technology;Heart Diseases;heart rate variability;high risk;Hormonal;Hour;indexing;Individual;Inflammation;insight;insulin sensitivity;Investigation;Link;Lipoproteins;Measures;men;Mental Health;Mentors;Metabolic;mHealth;modifiable risk;Monitor;Motivation;Myocardial Infarction;Myocardial Ischemia;National Heart, Lung, and Blood Institute;Nervous System Physiology;older women;Outcome;outcome disparities;Participant;Pathway interactions;Patient Self-Report;Pattern;personalized intervention;Physical activity;physical inactivity;physical symptom;Physiological;Physiology;Plasma;Play;Policies;Policy Maker;Population;post intervention;Prevention;Prevention program;primary outcome;Prognosis;protective factors;Psyche structure;Psychological Stress;Public Health;Reporting;Research;Research Project Grants;Risk Factors;Risk Reduction;Role;sex;Sex Differences;Stress;stress reduction;therapy design;Training;United States;United States Dept. of Health and Human Services;Woman;women versus men;Women's mortality;Work;Wrist;young man;young woman

PROJECT_TITLE: Investigation of Sex Differences in Physical Activity and its Relationships with Stress After Myocardial Infarction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-E(20)L]


ORG_CITY: BALTIMORE

ORG_NAME: MARYLAND STATE DEPARTMENT OF HEALTH

ORG_STATE: MD

PHR: PROJECT NARRATIVE: Of the 48 million Americans who suffer ~250 different kinds of foodborne illness each year, nearly 128,000 will need hospitalization and 3,000 will ultimately die from these entirely preventable diseases. Technological advances now promise to make large-scale food testing for key threats feasible, thereby intercepting dangerous foods before they enter households, and streamlining food protection strategies of the future. The Maryland public health laboratory has made major investments in its infrastructure over the past ~5 years, and now offers these extensive and proven capabilities to large-scale, multidisciplinary food protection through this cooperative agreement.

PI_NAMEs: URBAN, SINISA  (contact)

PROGRAM_OFFICER_NAME: CHRYSOGELOS, CHRISTINA

PROJECT_TITLE: Contributing a comprehensive and integrated food protection laboratory hub from Maryland


ORG_CITY: BATON ROUGE

ORG_NAME: LOUISIANA STATE OFFICE OF PUBLIC HEALTH

ORG_STATE: LA

PHR: NARMS Cooperative Agreement Program to Enhance and Strengthen Antibiotic  Resistance Surveillance in Retail Food Specimens  Agency Funding Opportunity Number: PA-20-124 Louisiana 7/1/2020-6/30/2021 Narrative The retail meat program monitors trends in antibiotic resistance in retail meat items and other items, as may be requested by FDA. Activities include testing and whole genome sequencing for antibiotic resistance in Salmonella, Campylobacter, Enterococcus, Vibrio, Aeromonas, and lactose fermenting gram-negative organisms (potentially E. coli) isolated from meat items purchased at retail food stores per FDA protocol.

PI_NAMEs: BUNCH, AMY  (contact)

PROJECT_TITLE: National Antimicrobial Resistance Monitoring System using Retail Meat for Louisiana


ORG_NAME: CONNECTICUT AGRICULTURAL EXPERIMENT STA

PHR: The Connecticut Agricultural Experiment Station 123 HUNTINGTON STREET, P.O. BOX 1106, NEW HAVEN, CONNECTICUT 06504  Putting Science to Work for Society Protecting Agriculture, Public Health, and the Environment Founded 1875 Project Narrative- This proposal, entitled “FDA LFFM- Continuation of human and animal food/feed programs at the CT Agricultural Experiment Station” includes 7 different projects encompassing Food Defense, Human Food Product Testing, Animal Food Product Testing, Chemistry Capability/Capacity Development, Sample Collection, NFDSX and ORAPP Integration, and Method Development/Validation. The CT AES has demonstrated the expertise, capability, and adaptability to fully meet the objectives of this FOA through our successful participation in a number of FDA CAPs. Receipt of this new award from FDA will significantly enhance the ability of the CT AES specifically, and CT in general, to meet the program goals laid out in the FOA, and as described by the President’s Food Safety Working Group, the Partnership for Food Protection and the Food Safety Modernization Act. Phone: (203) 974-8500 Fax: (203) 974-8502  Toll Free: 1-(877) 855-2237, CAES@CT.GOV PORTAL.CT.GOV/CAES An Affirmative Action/Equal Opportunity Employer

PI_NAMEs: WHITE, JASON C (contact)


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative The Wisconsin State Laboratory of Hygiene seeks to create a baseline of radiological levels found in Wisconsin’s raw milk and by extension, dairy products through the establishment of a statewide sampling, monitoring, and testing program. The program would begin with the surrounding county and expand over the course of four years to encompass the entire state. Initial testing would be focused on gamma emitters, with alpha and beta emitters being added to the program within two years of inception.

PI_NAMEs: WOUTERS, JESSE  (contact)

PROJECT_TITLE: The Wisconsin State Laboratory of Hygiene's Proposal to create a baseline of radiological levels found in Wisconsin's raw milk and by extension, dairy products


NIH_SPENDING_CATS: Chronic Pain;Hematology;Neurosciences;Pain Research;Rare Diseases;Sickle Cell Disease

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: Project Narrative: While heme in red blood cells is essential for transporting oxygen in the bloodstream, freely circulating heme is a cytotoxic threat that drives systemic inflammation and organ failure in sickle cell disease. This proposal tests the hypothesis that heme is also an essential driver of stimulus-evoked and ongoing, non-evoked pain in sickle cell disease. Understanding the role of elevated heme in the maintenance of pain behavior and sensory neuronal hyperexcitability will aid in the development of novel therapies that reduce the immense burden of SCD pain without the punishing side effects of opioids and neuropathic pain medications.

PI_NAMEs: ZORN, SAMUEL JOSHUA (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Action Potentials;Acute;Acute Pain;Adolescence;Afferent Neurons;Analgesics;Animals;Behavior;Behavioral;Biological Assay;Blood Circulation;C57BL/6 Mouse;Cells;Chlorides;Chronic;chronic pain;Clinical Research;Complex;cytotoxic;Data;Development;Disease;Electrophysiology (science);Erythrocytes;experience;experimental study;Extravasation;Face;Foundations;Frequencies;Genes;Haptoglobins;Harvest;Heme;heme a;Hemin;Hemoglobinopathies;Hemolysis;Hypersensitivity;improved;In Vitro;in vivo;Individual;Induced Neurons;Inflammatory;inflammatory pain;Inherited;inhibitor;Injections;intraperitoneal;Macrophage;Maintenance;Mechanics;Mediating;Mus;Nerve Fibers;Neurons;Nociception;Nociceptors;novel;novel therapeutics;Opioid;Organ failure;oxygen transport;Pain;pain behavior;Pain management;pain outcome;pain reduction;painful neuropathy;patch clamp;Pathogenesis;Pathologic;Pathology;Patients;Peripheral;Persistent pain;pre-clinical;pre-clinical research;Punishment;Quality of life;receptor;Recurrence;release of sequestered calcium ion into cytoplasm;Role;Sensory;Sickle Cell Anemia;sickling;side effect;Signal Transduction;Sodium Chloride;Spinal Ganglia;spontaneous pain;Stimulus;Structure of tibial nerve;Symptoms;systemic inflammatory response;Temperature;Testing;Tissues;TLR4 gene;Touch sensation;Wild Type Mouse

PROJECT_TITLE: Investigating the Role of Heme in Acute and Chronic Sickle Cell Disease Pain


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative To inspire a new generation of underrepresented minority (URM) students to pursue research careers in cardiovascular disease (CVD) and related comorbidities, we propose a five-year, disparities-focused research training program for undergraduate college students from the United States Virgin Islands (USVI). An eight- week intensive summer research institute, the Cardiovascular Research Empowerment Workforce (CREW) aims to advance health equity by supporting the training and career development of the next cadre of underrepresented minoritized researchers. As the USVI is a designated health professional shortage area, the proposed program will strengthen the local healthcare infrastructure by preparing emerging scholars to conduct evidence-based research within the local healthcare context, succeed in graduate school, and pursue a cardiovascular-focused research career in the USVI.

PI_NAMEs: CARRASQUILLO, OLVEEN ;JONES, DEBORAH LYNNE;KENYA, SONJIA  (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Address;Admission activity;Basic Science;Black race;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;career;Career Choice;career development;catalyst;Clinical Sciences;cohort;Collaborations;comorbidity;Data;Development;disease disparity;Disease Outcome;Disparity;Educational Curriculum;empowerment;Environment;evidence base;Evidence based intervention;experience;Exposure to;Face;Faculty;Fellowship;Florida;Funding;Generations;Geography;Goals;graduate school;graduate school preparation;Health;health disparity;health equity;Health Personnel;health professional shortage areas;Health system;Healthcare;Healthcare Systems;Historically Black Colleges and Universities;human capital;Immersion;Infrastructure;innovation;Interdisciplinary Study;interest;International;Knowledge;Learning;Medical;Medical Research;medical schools;Medicine;Mentors;Mentorship;minority investigator;Mission;Modeling;Motivation;Participant;Positioning Attribute;Preparation;programs;Public Health;Reporting;Research;Research Design;Research Infrastructure;Research Institute;Research Project Grants;Research Training;response;Risk Factors;Schools;Science;Scientist;skills;Sleep;Sleep Disorders;Stroke;Structure;summer research;support network;System;Teaching Hospitals;Training;Training and Infrastructure;Training Programs;Training Support;Translational Research;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Minority;underrepresented minority student;United States Dept. of Health and Human Services;United States Health Resources and Services Administration;United States Virgin Islands;Universities;university student


NIH_SPENDING_CATS: Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Human congenital eye abnormalities are frequently caused by mutations in genes encoding DNA-binding transcription factors (TFs) and various components of signal transduction pathways. Mutations in TF PAX6 cause human aniridia, a panocular disease that displays absence or hypoplasia of iris together with abnormalities in all major eye tissues, including the cornea, lens and retina. The microphthalmia, anophthalmia and coloboma (MAC) ocular syndrome includes over 30 genes. Amongst them, PAX6, SOX2 and retinoic acid (RA) signaling play prominent roles in eye development. However, the molecular mechanisms and function of individual missense and nonsense mutations in PAX6 and SOX2 genes remain unknown and use of vitamin A offers correction of some of these abnormalities.

PI_NAMEs: CVEKL, ALES  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Affect;Aniridia;Anophthalmos;Antibodies;ATAC-seq;Automobile Driving;Binding;Binding Sites;Biological Models;Brain;Candidate Disease Gene;candidate identification;Cataract;Cell Culture Techniques;Cell Lineage;Cells;ChIP-seq;Chromatin;Cleavage Under Targets and Release Using Nuclease;Code;Coloboma;comparative;Compensation;Computing Methodologies;congenital eye disease;Cornea;Data;Development;Disease;DNA Binding;Embryo;embryonic stem cell;Environment;Exhibits;Eye;Eye Abnormalities;Eye Development;Eye diseases;eye formation;Foundations;Functional disorder;gain of function;Gene Expression;Genes;Genetic;Genetic Diseases;genome-wide;genome-wide analysis;Glaucoma;Heterozygote;High Mobility Group Proteins;Human;human disease;in vitro Model;in vivo;Individual;induced pluripotent stem cell;Inherited;insight;Irido-corneo-trabecular dysgenesis;Iris;Knockout Mice;Knowledge;Laboratories;LacZ Genes;lens;Lens development;Link;Messenger RNA;Microphthalmos;Missense Mutation;Modality;Modeling;Molecular;mouse model;Mus;Mutant Strains Mice;Mutate;Mutation;Nonsense Mutation;Nonsense-Mediated Decay;novel;Ocular Pathology;optic cup;Organoids;Outcome;personalized medicine;Phenotype;Play;Procedures;Production;Property;Proteins;Retina;retinal progenitor cell;Role;Signal Transduction;Signal Transduction Pathway;single-cell RNA sequencing;stem cells;Syndrome;System;Testing;TGF Beta Signaling Pathway;therapy development;Time;Tissues;transcription factor;transcriptome sequencing;transcriptomics;Tretinoin;Untranslated RNA;Vitamin A

PROJECT_TITLE: Pax6 as a key regulator of lens development

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Primary Health Care;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE Social Determinants of Health have repeatedly been shown to have a significant impact on physical and mental health outcomes and may be a key driver of population level health disparities. This investigation seeks to understand how primary care providers understand, evaluate, and seek to address these social conditions in the outpatient primary care context. The overarching goal is to improve primary care management of patients with complex social conditions in such a way that appreciates and addresses the influence of multiple factors on the provision of social care in the clinical setting.

PI_NAMEs: WARPINSKI, CHLOE L (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: Address;Advocate;Affect;Anthropology;Area;Arts;Attention;Belief;Bioinformatics;Caring;Characteristics;Clinic;Clinic Visits;Clinical;clinical care;clinical implementation;Clinical Medicine;clinical practice;Clinical Services;clinical translation;clinically relevant;college;Communities;Community Health;Complex;Conceptual Domain;Consensus;contextual factors;Data;defined contribution;design;Development;Dissemination and Implementation;Documentation;Education;Ethnography;Exhibits;experience;Family Practice;Fellowship;Florida;Food;Goals;Grant;Health;health disparity;health equity;Health Services;Health Services Research;implementation design;implementation science;improved;Individual;Information Dissemination;Institutional Racism;Interdisciplinary Study;interest;Intervention;Interview;Investigation;Justice;knowledge translation;Length;Life Cycle Stages;Life Experience;Literature;Medicine;Mental Health;Methods;model development;Modeling;Movement;National Institute on Minority Health and Health Disparities;neglect;Outcome;Outpatients;Patient Care Management;patient population;Patients;Pattern;Personal Satisfaction;physical conditioning;Physicians;Population;Population Characteristics;Poverty;Primary Care;primary care clinic;primary care provider;Process;Provider;Research;Research Project Grants;Resources;response;Science;Scientist;Screening procedure;skills;social;Social Conditions;social health determinants;Social outcome;social science research;Social Sciences;Special Population;Structure;Testing;therapy development;Time;Training;Translational Research;Transportation;United States;Universities;Visit

PROJECT_TITLE: Ethnographic investigation of factors affecting conceptualization and provision of social prescribing in outpatient primary care clinics in the United States


ORG_CITY: HERSHEY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE Obesity is a worldwide health problem that increases the risk for hypertension and cardiovascular disease; however, the molecular mechanisms connecting obesity with hypertension and optimal therapies to lower blood pressure in this disease remain unclear. This proposal will test the hypothesis that angiotensin-(1-7), a protective hormone of the renin-angiotensin system, engages inhibitory signaling pathways within the hypothalamus of the brain to lower blood pressure in obesity hypertension using innovative transgenic mouse models combined with gold standard physiological, pharmacological and molecular approaches. The findings from this proposal will provide new insight into how angiotensin-(1-7) interacts with the brain to lower blood pressure as well as the potential for targeting Ang-(1-7) as a new treatment for obesity hypertension.

PI_NAMEs: VERNAIL, VICTORIA LYNN (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Address;angiotensin I (1-7);Animal Model;Animals;antagonist;Anti-Hypertensive Agents;Area;Attenuated;Binding;Blood Pressure;blood pressure elevation;blood pressure reduction;Body Weight decreased;Brain;Cardiac;Cardiovascular Diseases;Cardiovascular system;career;Cells;Chronic;Clinical;clinically relevant;comparison control;Data;diet-induced obesity;dietary control;Disease;Electrophysiology (science);Epidemic;experimental study;gamma-Aminobutyric Acid;Goals;Health;High Fat Diet;Hormones;Hypertension;hypertension treatment;hypertensive;Hypothalamic structure;improved;innovation;insight;Institution;Insulin;insulin sensitivity;Knockout Mice;lipid metabolism;Measures;Melanocortin 4 Receptor;Mentorship;Metabolic;metabolic profile;Methods;Molecular;mouse model;Mus;neural circuit;neuromechanism;Neurons;Neurosciences;Neurosciences Research;neurotransmission;Neurotransmitters;new therapeutic target;novel;Obese Mice;Obesity;Obesity Related Hypertension;obesity treatment;optimal treatments;paraventricular nucleus;patch clamp;Pathway interactions;patient population;Peripheral;Pharmaceutical Preparations;pharmacologic;Physiological;presynaptic;prevent;Pro-Opiomelanocortin;receptor;Receptor Signaling;Regulation;Renin-Angiotensin System;Research;Research Personnel;response;Rest;Risk;Rodent;Saline;side effect;Signal Pathway;Signal Transduction;skills;Structure of nucleus infundibularis hypothalami;Testing;therapeutic target;Tissues;Transgenic Mice;transmission process;treatment comparison;treatment guidelines;treatment strategy;Work

PROJECT_TITLE: Angiotensin-(1-7) engages hypothalamic arcuate-paraventricular nucleus inhibitory pathways to lower blood pressure


NIH_SPENDING_CATS: Cardiovascular;Hypertension

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Approximately 10% of patients using current hypertensive therapies show resistance to these treatments, leading to uncontrolled blood pressure and increased adverse outcomes. As phospholipase C (PLC) activity is at the core of hypertensive signaling, the proposed research will identify which isoforms of diacylglycerol kinase and phospholipase D regulate PLC signaling through phosphatidic acid production. Therefore, this project is relevant to public health as it will aid in the discovery of isoform-specific antihypertensive targets that are less susceptible to resistance.

PI_NAMEs: WECKERLY, CLAIRE  (contact)

PROJECT_TERMS: adverse outcome;Affect;Angiotensins;Anti-Hypertensive Agents;Biosensor;Blood Pressure;blood pressure elevation;Calcium Channel Blockers;Cell membrane;Cell model;Cells;CRISPR/Cas technology;Diacylglycerol Kinase;Diglycerides;Disease;druggable target;Enzymes;Feedback;Genetic;Homeostasis;Hypertension;hypertensive;Individual;inhibitor;inorganic phosphate;Inositol;Isoenzymes;knock-down;Link;Lipids;Mediating;Membrane Lipids;Metabolic Pathway;Metabolism;new therapeutic target;novel;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phosphatidic Acid;Phosphatidylinositol 4,5-Diphosphate;phosphatidylinositol 4-phosphate;Phosphatidylinositols;Phospholipase C;Phospholipase D;Phosphorylation;Phosphotransferases;Physiological;Predisposition;Process;Production;Protein Isoforms;Proteomics;Public Health;recruit;Recycling;Regulation;Research;Research Design;Resistance;Resistant Hypertension;Role;Signal Transduction;Testing;vasoconstriction;Work

PROJECT_TITLE: The roles of PLD and DGK isoforms in PIP2 homeostasis during PLC signaling


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Immunization;Infectious Diseases;Networking and Information Technology R&D (NITRD);Vaccine Related

ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE The adaptive immune system is responsible for mounting responses to specific pathogens based on previous encounters, known as immunological memory, which can provide long-lasting protection. This project will investigate a critical way in which genetics can influence the ability of our immune system to distinguish what is foreign from what is self. Such studies are essential to understand how vaccine responses may differ between individuals, and serve as a potential basis for effectively designing personalized immunization strategies to increase vaccine efficacy for diverse populations.

PI_NAMEs: LEE, NOAH YANN (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Acceleration;Acute;adaptive immune response;Adaptive Immune System;Address;Algorithmic Analysis;Algorithms;Alleles;analysis pipeline;Antibodies;Antigen Receptors;Antigens;Autoimmunity;B-cell receptor repertoire sequencing;B-Lymphocytes;Biological;Cell surface;cell type;Cells;Cellular biology;cohort;Communities;Complex;Computing Methodologies;Data;Data Set;design;Development;Disease;DNA Sequence Alteration;Drops;Future;Genes;Genetic;genetic analysis;Genetic Markers;Genetic Recombination;Genetic Transcription;genome wide association study;Genomics;Genotype;Germ Lines;Goals;Grouping;Haplotypes;heuristics;HIV Antibodies;Immune response;Immune system;Immunogenetics;immunoglobulin B;Immunoglobulin Genes;Immunoglobulin Variable Region;Immunoglobulins;Immunologic Memory;Immunologic Receptors;Immunologics;Immunology;improved;Individual;Infection;Influenza;interest;Link;machine learning model;Methodology;Methods;Modeling;Multiomic Data;Mutation;Nature;neutralizing antibody;novel;Outcome;pathogen;Pathogenicity;Patients;Pattern;personalized health care;Phenotype;Population;Population Heterogeneity;Process;public repository;Receptor Cell;Research;response;RNA;Somatic Cell;Sorting;Specificity;Stereotyping;success;Surface;Testing;tool;Training;transcriptomics;trend;Vaccination;vaccination strategy;vaccine efficacy;vaccine response;Variant;Work

PROJECT_TITLE: Computational Methods for Analyzing lmmunoglobulin Allelic Diversity in B cells


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Electronic Nicotine Delivery Systems;Health Effects of Indoor Air Pollution;Nanotechnology;Prevention;Tobacco

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE The Program on Occupational health and safety education on Emerging Technologies – Mid Atlantic Partnership (POccETMAP) is collaborative effort between multiple institutions to develop and widely distribute a web-based curriculum to prepare students in industrial hygiene, STEM disciplines, and OHS professionals with the skills necessary to address health and safety issues that arise in emerging technology areas including additive manufacturing such as 3-D printing, novel technologies for disinfection, electronic nicotine delivery systems, and nanobiotechnology.

PI_NAMEs: RAMACHANDRAN, GURUMURTHY  (contact)

PROGRAM_OFFICER_NAME: CARLIN, DANIELLE J

PROJECT_TERMS: 3-Dimensional;3D Print;Acceleration;Address;Adoption;Ammonium;animation;antimicrobial;Area;Biological Products;Chemical Exposure;Chemicals;Collection;Continuing Education;COVID-19 pandemic;Deposition;design;Detection;Development;Dimensions;Disasters;Discipline;Disinfection;doctoral student;Education;Educational Curriculum;Electronic cigarette;Electronic Nicotine Delivery Systems;Emerging Technologies;Engineering;Ensure;Environment;Epidemic;Exercise;experience;Exposure to;Film;flexibility;Fostering;Frontline worker;Funding;Future;Hazardous Substances;Health;Health Personnel;Heavy Metals;Home;Hour;Hydrogen Peroxide;Industrial Health;Industry;Infectious Agent;innovation;Institution;instructor;Interdisciplinary Education;Internet;Laboratories;Lead;Learning;Learning Module;Libraries;manufacture;manufacturing technology;Maryland;Medical Device;medical implant;Medicine;metal oxide;Modeling;nanobiotechnology;nanoparticle;nanoscale;nanotherapeutic;Narration;new technology;next generation;novel;Occupational;occupational health/safety;Online Systems;Penetration;Pharmaceutical Preparations;Population;Printing;Process;Production;programs;Property;Readiness;real world application;Research;Research Personnel;Risk;Risk Management;Safety;safety education;Schools;Science;Scientist;skills;Specialist;STEM field;Students;Styrenes;Surface;Sustainable Development;synergism;Technology;Time;Training;Training Activity;Training and Education;Ultraviolet Rays;undergraduate research experience;Universities;Work;Workplace;young adult

PROJECT_TITLE: Program on Occupational Health and Safety Education on Emerging Technologies - Mid Atlantic Partnership (POccET MAP)


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Diabetes technology, such as insulin pumps and continuous glucose monitoring devices, can help improve glucose control for people with type 1 diabetes (T1D), which keeps them at lower risk for diabetes complications, but many Latinx adolescents, who make up the largest marginalized ethnic group of youth with T1D in California, use these devices less often and have less optimal glucose control compared to White youth. The goals of this project are to work directly with Latinx youth, their families, and diabetes care team members in California to develop DREAM, Device use Reimagined through Education And Mentorship, a virtual peer group (VPG) intervention that will encourage and support the use of diabetes devices in Latinx adolescents with T1D. With these stakeholders, the researchers will design and pilot test the feasibility of DREAM, and the results of the study will be used to improve the use of diabetes technology and clinical and patient-centered outcomes for Latinx youth with T1D.

PI_NAMEs: RAYMOND, JENNIFER K;WONG, JENISE C (contact)

PROGRAM_OFFICER_NAME: THORNTON, PAMELA L

PROJECT_TERMS: acceptability and feasibility;Achievement;Address;Adolescent;Adolescent and Young Adult;Adoption;adverse outcome;age group;aged;arm;Attitude;Black race;blood glucose regulation;California;Caring;Childhood;Childhood diabetes;Clinic;Clinical;clinical center;Clinical Trials;Collaborations;Communities;comparison control;Complications of Diabetes Mellitus;Continuous Glucose Monitor;Data;design;Development;Device Designs;Devices;diabetes distress;Diabetes Mellitus;diabetes risk;diabetes self-management;Doctor of Philosophy;Education;Endocrinologist;ethnic diversity;Ethnic Population;Evaluation;experience;Family;feasibility testing;Feedback;Focus Groups;future implementation;Geography;glycemic control;Goals;Grant;group intervention;Health;health care service utilization;Health Personnel;Hemoglobin concentration result;high risk;hospital utilization;improved;Insulin;Insulin Infusion Systems;Insulin-Dependent Diabetes Mellitus;Intervention;Interview;Knowledge;Latinx;Latinx population;Los Angeles;Maintenance;marginalization;Measures;Medical;medical appointment;member;Mentorship;Modeling;monitoring device;multidisciplinary;novel;optimism;Outcome;Participant;patient engagement;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Pediatric Hospitals;peer;Peer Group;peer support;Persons;Phase;pilot test;Population;Population Heterogeneity;pragmatic trial;prevent;primary outcome;Process Measure;programs;Provider;Psychologist;Public Health;Pump;Quality of life;Race;recruit;Reporting;Research;Research Personnel;San Francisco;satisfaction;social;stakeholder perspectives;Structure;System;Technology;telehealth;therapy design;Universities;uptake;virtual;Visit;Work;Youth

PROJECT_TITLE: Optimizing diabetes technology use for Latinx youth through DREAM (Device use Reimagined through Education And Mentorship) virtual peer groups


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: OVERALL: PROJECT NARRATIVE The Columbia University Senescence Tissue Mapping (CUSTMAP) Center is a highly collaborative effort that builds upon long-standing and established collaborations between Columbia University Irving Medical Center (CUIMC), The University of Edinburgh, New York University (NYU), and the New York Genome Center (NYGC). Using state-of-the-art spatial genomics technologies and drawing upon tissues available from a diverse patient population in Upper Manhattan, CUSTMAP will generate three-dimensional maps of senescent cells in healthy tissues from the central nervous system (brain and spinal cord) and the skin. The experimental approaches, workflow, and computational tools implemented by CUSTMAP provide a unique platform for driving transformative discoveries of novel molecular, cellular, and regional correlates of age-related changes in cellular senescence in human tissues, which can be generalized to other tissue types and efficiently shared with and deployed across the SenNet Consortium.

PI_NAMEs: CHRISTIANO, ANGELA M;MENON, VILAS ;PHATNANI, HEMALI  (contact);SUH, YOUSIN

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: 3-Dimensional;Address;Adult;Affect;Age;age related;age related changes;Aging;Atlases;Automobile Driving;Autopsy;biobank;Biological;Biology of Aging;Blood;Brain;Cell Aging;cell type;Cells;Central Nervous System;Cerebrospinal Fluid;Clinical;Collaborations;Communities;computerized tools;Data;Data Analyses;Data Collection;data integration;Data Science;Dermatologic;Dermatology;Ensure;Environment;ethnic diversity;experience;experimental study;Fostering;Gene Expression Profile;Genome;genome-wide;genomic data;Genomics;Geographic Locations;Goals;Heterogeneity;Human;human tissue;Image;Indirect Immunofluorescence;Individual;innovation;Knowledge;Leadership;life span;Maps;Medical center;Modality;Molecular;molecular phenotype;Molecular Profiling;multi-scale atlas;multidisciplinary;multiple omics;Neurology;neuropathology;New York;novel;novel marker;Pathologic;Pathology;patient population;Phase;Phenotype;Population Heterogeneity;Procedures;Process;prospective;protein expression;Proteomics;Protocols documentation;racial diversity;regenerative;Reproductive Biology;Research;Research Personnel;Resolution;Resources;Sampling;senescence;senescent cell;single nucleus RNA-sequencing;Skin;Skin Tissue;Spinal Cord;Structure;success;synergism;Techniques;Technology;Tissue Banks;tissue mapping;Tissue Procurements;Tissue Sample;Tissues;tool;transcriptomics;Universities;Visualization;Work

PROJECT_TITLE: A Multi-scale Atlas of Senescence in Diverse Tissue Types

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(70)R]


NIH_SPENDING_CATS: Clinical Research

PI_NAMEs: PHATNANI, HEMALI  (contact)

PROJECT_TERMS: Adherence;Adult;aging related;Agreement;Annual Reports;Atlases;Biological;Biological Assay;Biological Markers;Blood;Brain;Cell Aging;Cells;Cerebrospinal Fluid;Collaborations;Common Data Element;Communication;Communities;Consent;Data;Data Analyses;Data Coordinating Center;Data Set;data sharing;Decision Making;Disease;Documentation;Ectoderm;Ensure;Environment;Ethics;Evaluation;Evaluation Reports;Feedback;Fostering;Genome;Goals;Health;Heterogeneity;Human;implementation facilitation;Infrastructure;innovation;Knowledge;Laboratories;Leadership;life span;Management Information Systems;Maps;meetings;Metadata;Molecular;Monitor;multi-scale atlas;multidisciplinary;multimodality;New York;novel;organizational structure;Output;Policies;programs;Progress Reports;Protocols documentation;Research;Resolution;Resource Sharing;Resources;Role;Sampling;senescence;senescent cell;Site;Skin;Spinal Cord;Standardization;Structure;success;synergism;System;tissue mapping;Tissue Procurements;Tissues;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Mitochondria are double-membrane bound organelles that perform many cellular functions, including the generation of energy via respiration. Spatial organization of the mitochondrial inner membrane is crucial for efficient energy production, though the mechanisms that generate mitochondrial architecture are poorly understood. The proposed work will determine the mechanistic and functional roles of the evolutionarily- conserved MICOS complex, a key modulator of mitochondrial morphology, and identify novel regulators of its function with the long-term goal of identifying therapeutic approaches to alleviate diseases with underlying mitochondrial dysfunction.

PI_NAMEs: FRIEDMAN, JONATHAN R. (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Address;Alzheimer's Disease;amino acid metabolism;Architecture;Binding;Cell Physiology;Cell Respiration;Cells;Complex;Crista ampullaris;Defect;Development;Disease;Elements;energy efficiency;Future;Generations;genetic approach;Goals;Homeostasis;Human;human disease;Inner mitochondrial membrane;insight;Ions;Lead;Link;Membrane;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Molecular;Morphogenesis;Morphology;Neurodegenerative Disorders;novel;Nucleotides;Organelles;Oxidative Phosphorylation;Parkinson Disease;Phenotype;Phospholipids;Positioning Attribute;Production;programs;Research;Respiration;Role;Shapes;Site;System;Therapeutic;Work;Yeasts

PROJECT_TITLE: Spatial Organization of the Mitochondrial Inner Membrane

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


PI_NAMEs: OWENS, DAVID MICHAEL (contact)

PROJECT_TERMS: Age;age effect;age related;age-related disease;aged;Aging;Atlases;Autopsy;biobank;Biological;Blood;Blood Vessels;Body System;Brain;cell injury;cell type;Central Nervous System;Cerebrospinal Fluid;Clinical;clinical phenotype;Cognitive;cohort;Collaborations;Collection;Complex;Consent;Data;Data Linkages;data sharing;Dermatopathology;Disease;Ear;Environmental Exposure;Ethnic Origin;Evaluation;Foundations;Freezing;Gene Expression Profile;Genetic;Goals;Histopathology;Human;human tissue;Individual;innovation;International;Leadership;life span;Link;Medical center;Methodology;Methods;Microscopic;Molecular;Molecular Profiling;multi-scale atlas;neuropathology;New York;normal aging;Operative Surgical Procedures;Organ;Outcome;Paraffin;Pathologic;Pathology;Phenotype;Positioning Attribute;Predisposition;Prefrontal Cortex;Process;prospective;Proteins;regenerative;Research;Resources;Sampling;senescence;Site;Skin;Spinal Cord;Stains;Standardization;Subjects Selections;Sun Exposure;synergism;System;Techniques;Time;Tissue Banks;tissue mapping;Tissues;Universities

PROJECT_TITLE: Biospecimen Core


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Precision Medicine;Prostate Cancer;Urologic Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The field of precision oncology continues to evolve with the overarching goal of providing cancer patients with enhanced diagnostic/prognostic capabilities and efficacious treatments. Through the research proposed here, we will use our expertise in translational cancer research to advance this mission by contributing new bioinformatics resources to the research community, identifying biomarkers of disease for diagnosis or prognosis of different cancer types, nominating these markers for development of therapeutic targeting agents, and performing studies to understand their biological roles in cancer progression.

PI_NAMEs: CHINNAIYAN, ARUL M (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Achievement;Advanced Malignant Neoplasm;Antisense Oligonucleotides;Area;Award;bioinformatics resource;Biological;biomarker identification;Cancer Intervention;Cancer Patient;cancer type;Clinical;clinical sequencing;Communities;Data;Development;Diagnosis;Diagnostic;disease diagnosis;Disseminated Malignant Neoplasm;efficacious treatment;ERG gene;experience;Gene Fusion;Goals;Human;Individual;inhibitor;knowledgebase;Malignant neoplasm of prostate;Malignant Neoplasms;Mission;Modeling;Molecular;Molecular Target;novel marker;Pathogenesis;Patients;Peptides;peptidomimetics;precision medicine;precision oncology;Prognosis;prognostic;programs;Prostate;PSA level;Reporting;Research;research clinical testing;Research Personnel;Resources;Role;Sampling;Screening for Prostate Cancer;Serum;single cell sequencing;targeted treatment;therapeutic development;Therapeutic Intervention;therapeutic target;TMPRSS2 gene;transcriptome;transcriptomics;translational cancer research;tumor progression;Untranslated RNA;Urine;Validation;Work

PROJECT_TITLE: Exploring Precision Oncology: From Gene Fusions to lncRNAs


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Narrative Individuals at risk of developing Alzheimer’s disease that are amyloid-β positive, but are still cognitively normal, exhibit a characteristic change in brain connectivity prior to the onset of clinical symptoms. However, the cause for these changes in brain connectivity are still unknown. In this proposal, I will use state-of-the-art neuroimaging techniques, such as in vivo two-photon microscopy, wide-field optical imaging, and magnetic resonance spectroscopy, to investigate changes in neuronal and glutamate activity and its impact on network connectivity response to amyloid-β exposure.

PI_NAMEs: COVER, CHRISTOPHER GREGORY (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: abeta accumulation;Acute;Address;Affect;Age Months;Aging;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease model;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Animals;APP-PS1;awake;Basic Science;Brain;Calcium;calcium indicator;career;Characteristics;Chronic;Clinical;clinical development;Clinical Sciences;clinically relevant;Cognition;Cognitive;Concentration measurement;Data;Dementia;Development;Disease;Disease Progression;Dose;early detection biomarkers;Early Diagnosis;Early Intervention;Early treatment;Event;excitatory neuron;excitotoxicity;Exhibits;experience;experimental study;extracellular;Fluorescence Microscopy;Functional disorder;Glutamates;Glutamine;Growth;Human;human imaging;human subject;Hyperactivity;Image;imaging approach;Impaired cognition;in vivo;in vivo fluorescence;Individual;interest;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measures;Memory impairment;Mentors;Microscopic;mouse model;Multimodal Imaging;Mus;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging;Neurology;neuronal circuitry;Neurons;neuropathology;neurophysiology;Neurotransmitters;novel;optical imaging;optical sensor;Optics;Pathology;Patients;Phase;Physicians;Physiological;predictive marker;Research Training;response;Risk;Rodent;Role;Scientist;sensor;Signal Transduction;Specificity;Spectrum Analysis;Symptoms;Synapses;tau Proteins;tau-1;Technical Expertise;Techniques;Testing;Training;translational model;treatment strategy;two photon microscopy;two-photon;United States;Wild Type Mouse;Work

PROJECT_TITLE: Neurophysiological Basis for Functional Connectivity Changes in Early Alzheimer’s Disease