NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Endocrine Disruptors;Estrogen;Prevention;Social Determinants of Health

ORG_CITY: EL CERRITO

ORG_NAME: MILLION MARKER WELLNESS INC.

PHR: Public Health Relevance Statement Million Marker is the first company to provide tools and services that allow people to understand their personal environmental chemical exposures (i.e. endocrine disrupting chemicals, EDCs) in order to prevent diseases and optimize their health by changing their lifestyle choices. This work aims to develop an affordable and scalable intervention program, with interactive curriculum and individualized support, that can be readily disseminated and commercialized to help customers reduce exposures to EDCs. Completion of this proposal will allow Million Marker to offer EDC testing and intervention to the general public, thus taking steps to address this global health crisis.

PI_NAMEs: HUA, JENNA  (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Address;Adult;Age;Analytical Chemistry;arm;Asthma;Awareness;Back;Behavioral;Biological Markers;Biological Monitoring;Biometry;Businesses;Chemical Exposure;chemical reduction;Chemicals;child bearing;Chronic Disease;Clinic;Clinical;clinical care;cohort;commercialization;compare effectiveness;cost effective;Counseling;crowdsourcing;curriculum development;Curriculum Management System;Data Engineering;Diabetes Mellitus;diabetes prevention program;digital;digital intervention;Disease;Economic Burden;Educational Curriculum;effectiveness testing;empowerment;Endocrine Disruptors;environmental chemical;environmental chemical exposure;Environmental Epidemiology;Environmental Exposure;Environmental Health;experience;Exposure to;Female;Female of child bearing age;Fertility;Fetus;General Population;Genetic;genetic testing;global health;Health;health literacy;healthy lifestyle;human centered design;Hypersensitivity;Hypospadias;improved;Individual;Infertility;instrument;Insurance Coverage;Intervention;intervention program;Knowledge;Learning;Letters;Life Style;Link;literacy;Low Birth Weight Infant;male;Malignant Breast Neoplasm;Marketing;Measures;men;Metabolic syndrome;Mission;mobile application;Modeling;multidisciplinary;Nevada;online intervention;Outcome;Outcome Assessment;Parabens;Participant;Patient Recruitments;Patients;Personal Satisfaction;Persons;Phase;phase 1 study;phthalates;Population;population health;Positioning Attribute;post intervention;Precision Health;precision medicine;Predisposition;Pregnancy;Premature Birth;prevent;Process;programs;public health relevance;Randomized;Randomized, Controlled Trials;Readiness;recruit;Reporting;reproductive;Research;response;Sampling;satisfaction;Science;Scientist;Self Direction;service intervention;Services;Surveys;System;Target Populations;Testing;testing services;tool;Toxicology;Training;treatment arm;trend;Urine;usability;Vision;Well in self;Woman;Work

PROJECT_TITLE: A Personalized Digital Intervention Program to Reduce Exposure to Endocrine Disrupting Chemicals among a Child-Bearing Age Cohort


ADMINISTERING_IC: EB

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Heart Disease;Lung;Pulmonary Hypertension

ORG_CITY: ITHACA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_FIPS: US

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative Measurements of blood pressure are broadly used as a cardiovascular health indicator, but the common cuff-based device by artery occlusion cannot be reliably translated into the central systemic circulation and will miss the entire pulmonary circulation. We propose to develop a noninvasive wearable radio-frequency sensor to measure the instantaneous vibration characteristics of the aorta and pulmonary artery, which can then in turn be used to derive the entire blood pressure transients in each heartbeat, including the systolic and diastolic blood pressures of the systemic and pulmonary circulation. A mechanical model and a pig animal model will be employed to verify the measurement accuracy against the gold-standard catheter-based fluid pressure-volume sensor.

PI_NAMEs: ARAOS, JOAQUIN ;KAN, EDWIN C (contact)

PROGRAM_OFFICER_NAME: LASH, TIFFANI BAILEY

PROJECT_TERMS: Acute;Adult;Agreement;Air;Algorithms;Anesthesia procedures;Anesthetics;Animal Model;Animals;Aorta;arm;Arrhythmia;artery occlusion;Benchmarking;Blood;Blood Pressure;Blood Pressure Monitors;Blood Vessels;brachial artery;Calibration;Cardiac;Cardiac Catheterization Procedures;Cardiopulmonary;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Catheterization;Catheters;Cessation of life;Characteristics;Chest;Circulation;Clinical;Computers;Critical Illness;Devices;Diagnosis;diagnosis standard;Diastolic blood pressure;Dimensions;disability;Disease Management;Distal;Doppler Effect;Echocardiography;electrical impedance tomography;Electrocardiogram;Evaluation;Family suidae;Fatty acid glycerol esters;Frequencies;Geometry;Healthcare;Heart;Heart Valves;hemodynamics;Home;Human;improved;Individual;Infusion procedures;Inpatients;instrument;Intensive Care Units;Liquid substance;Lung;Machine Learning;Magnetic Resonance Imaging;Maps;Measurement;Measures;Mechanics;Methods;Modeling;Modernization;modifiable risk;Monitor;mortality;Motion;MRI Scans;multiple input multiple output;Muscle;operation;Operative Surgical Procedures;Output;Oxygen;patient home care;Patients;Penetration;Performance;phantom model;Photoplethysmography;physical model;Physiologic pulse;Physiology;pressure;pressure sensor;Primary Care;pulmonary arterial pressure;Pulmonary artery structure;Pulmonary Circulation;Pulmonary Hypertension;Pulmonary Surfactants;pulmonary vascular disorder;Pump;Radar;radio frequency;recruit;Resolution;Respiration;right ventricular failure;Risk Factors;Scanning;sensor;signal processing;Skin;Sphygmomanometers;Structure of parenchyma of lung;surfactant;Systemic blood pressure;Systemic hypertension;Systolic Pressure;Techniques;Testing;Time;Tissues;Titrations;tonometry;Translating;Ultrasonography;ultrasound;Uncertainty;Vasoconstrictor Agents;Vasodilation;vibration;wearable device;X-Ray Computed Tomography

PROJECT_TITLE: Non-invasive measurements of central blood pressures by RF sensors

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Microbiome;Physical Activity

ORG_CITY: WINSTON-SALEM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Heart failure with preserved ejection fraction (HFpEF) is nearly unique to older persons, affects 2.5 million individuals, and has no proven medication treatments. In this project, we will test repurposing of metformin, a generic, inexpensive, well-tolerated drug with a wide range of beneficial anti-aging properties, to determine if it will improve symptoms and quality of life in older persons with HFpEF. We will also examine if metformin acts by improving inflammation originating from the bacterial environment in the gut (microbiome).

PI_NAMEs: KITZMAN, DALANE W (contact);YADAV, HARIOM

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: Address;adverse outcome;Affect;Age;Aging;aging mechanism;aging process;anti aging;Anti-diabetic Drugs;Antigens;Arteries;Bacteria;Blinded;Blood;Blood Circulation;Body Weight decreased;Butyrates;Cardiomyopathies;CD14 gene;Cessation of life;Circulation;Cities;Clinical;Clinical Research;Congestive Heart Failure;cytokine;Data;dietary;Diffusion;Dose;EFRAC;Elderly;Environment;Event;Exercise;exercise capacity;exercise intolerance;exercise training;FDA approved;Feces;follow-up;Foundations;Future;gastrointestinal epithelium;Goals;gut bacteria;gut inflammation;gut microbiome;gut microbiota;Health;Heart;Heart failure;heart function;Hospitalization;Human;Impairment;improved;improved outcome;indexing;Individual;Inflammation;inflammatory marker;Interleukin-1 beta;Interleukin-6;Intestines;Intravenous;Kansas;LCN2 gene;Leaky Gut;Left;Leukocyte L1 Antigen Complex;lipopolysaccharide-binding protein;Lung;Measurement;Measures;Mediating;Metformin;Microbe;microbial;microbiome;microbiota;Modeling;mouse model;Mucins;multidisciplinary;Nematoda;non-diabetic;older patient;Older Population;older women;optimal treatments;Oral;Organ;Oxygen Consumption;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Phase;Physical Function;Physical Performance;Physiological Processes;placebo controlled trial;Population;Positioning Attribute;preclinical study;preservation;Prevalence;Production;Prognosis;Property;Quality of life;Questionnaires;Randomized;Rodent;Role;Serum;SF-36;Skeletal Muscle;Source;symptomatic improvement;Symptoms;Syndrome;systemic inflammatory response;Testing;TNF gene;Underserved Population;Ventricular;Walking;Woman;Work

PROJECT_TITLE: Repurposing of Metormin for Older Patients with HFpEF


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: DALLAS

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Modified Public Health Relevance Section The nuclear protein PARP-1 is an enzyme that controls gene expression programs in a variety of hormone- and diet-regulated biological systems, including adipogenesis and inflammation.  Our proposed studies will shed new light on the molecular mechanisms underlying the control of gene expression by PARP-1 in preadipocytes and macrophages, two cell types in adipose tissue that function as important mediators of obesity.  Out studies may suggest better ways to target PARP-1 to regulate metabolism and mitigate the pathological effects of obesity.

PI_NAMEs: KRAUS, WILLIAM LEE (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Address;Adipocytes;Adipose tissue;Affect;Architecture;Binding Proteins;Biochemical;biochemical tools;Biological;Biological Assay;biological systems;Biology;Bone Marrow;Cell Physiology;cell type;Cells;Cellular biology;Chemicals;Chromatin;Diet;DNA Binding;DNA Repair;Enhancers;Enzymes;Event;experimental study;Family;Fatty acid glycerol esters;Future;Gene Expression;Gene Expression Regulation;Genes;genetic regulatory protein;Genetic Transcription;Genome;Genomics;High Fat Diet;Histones;Hormones;human disease;in vivo;Inflammation;Inflammatory Response;insight;Knock-in Mouse;Knock-out;Knowledge;Light;Link;lipid biosynthesis;Location;Macrophage;Maps;Mediating;Mediator;Metabolism;Modeling;Modification;Molecular;Molecular Biology;mouse genetics;mouse model;Mus;mutant;Nuclear;Nuclear Protein;Obesity;Outcome;Pathologic;pharmacologic;Physiological;Physiological Processes;Play;Polymerase;Post-Translational Protein Processing;Process;programs;promoter;Proteins;Proteomics;public health relevance;reconstitution;response;Role;Series;Shapes;Signal Transduction;Site;System;Testing;therapeutic target;Tissues;transcription factor;Transcriptional Regulation

PROJECT_TITLE: The Role of Nuclear PARPs in Signal-Regulated Transcription

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Depression;Health Services;Mental Health;Neurodegenerative;Neurosciences;Palliative Care;Prevention;Sleep Research;Telehealth

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative Poor sleep among persons with Alzheimer’s disease and related dementias (ADRD) and their caregivers negatively impacts both of their health outcomes and caregivers’ ability to keep their loved ones at home. This proposal will test efficacy of an innovative sleep intervention program (in-person and telehealth) that targets both members of the dyad simultaneously in a randomized controlled trial. Improved sleep in persons with ADRD and their caregivers may improve health and quality of life, and prevent or delay admission of ADRD patients to institutional settings, potentially leading to decreased healthcare costs.

PI_NAMEs: SONG, YEONSU  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: actigraphy;Address;Admission activity;Affect;Aftercare;Alzheimer's Disease;Alzheimer's disease related dementia;arm;Behavior;Behavioral;Behavioral Symptoms;Biological Markers;C-reactive protein;cardiovascular health;Caregiver Burden;Caregiver support;Caregivers;caregiving;center for epidemiological studies depression scale;cognitive benefits;cognitive function;Cognitive Therapy;Communities;community based service;community setting;comparison control;Control Groups;Dementia;Dementia caregivers;depressive symptoms;design;Education;efficacy evaluation;efficacy testing;experience;Family Caregiver;follow-up;global health;Goals;Health;Health Care Costs;Health Professional;health training;Home;human old age (65+);improved;improvement on sleep;Inflammation;Inflammatory;inflammatory marker;Information Systems;innovation;Institution;Interleukin-6;Intervention;intervention delivery;intervention effect;intervention program;Interview;Knowledge;Light;loved ones;Manuals;Measurement;Measures;member;Memory;Mental Depression;Mental Health;Modality;Outcome;Pathway interactions;Patient Outcomes Assessments;Patients;Personal Satisfaction;Persons;physical conditioning;Pittsburgh Sleep Quality Index;poor sleep;post intervention;prevent;primary outcome;Problem behavior;Problem Solving;programs;Quality of Care;Quality of life;randomized, clinical trials;Randomized, Controlled Trials;Role;secondary outcome;Sleep;sleep difficulty;Sleep Disorders;Sleep disturbances;sleep quality;Sleeplessness;Stress;telehealth;Testing;TNF gene;trial design;Underrepresented Populations;Vulnerable Populations;Walking;Work

PROJECT_TITLE: A Dyadic Approach to Improve Sleep and Well-Being Among Persons with Alzheimer's Disease and Their Caregivers

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: NS

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: BIOLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: PROJECT NARRATIVE Perturbations in blood clotting and inflammation are present in many Alzheimer’s disease (AD) patients. We will use purified proteins as well as mouse and human samples to study how the interaction between the pathogenic AD peptide Aβ and the blood protein fibrinogen leads to disease severity. These studies may help clarify the contributions of fibrin, the major blood clotting protein, in AD pathology to pave the way for new diagnostics and therapies for human AD patients.

PI_NAMEs: NORRIS, ERIN H;STRICKLAND, SIDNEY  (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: abeta toxicity;Affect;Affinity;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid beta-42;Amyloid beta-Protein;Binding;biophysical properties;biophysical techniques;Blood coagulation;Blood flow;Blood Proteins;Brain;Brain Pathology;Cell Communication;Cells;Coagulation Process;Complex;Culture Techniques;Cytolysis;Disease;Elements;Fibrin;Fibrinogen;Functional disorder;Goals;Hippocampus;Human;Imaging Techniques;Impaired cognition;improved;In Vitro;in vivo;Inflammation;Injections;Measures;Molecular;mouse model;Mus;mutant;Nerve Degeneration;neuroinflammation;neuron loss;Neuronal Dysfunction;novel;novel diagnostics;novel therapeutics;Pathogenesis;Pathogenicity;Pathway interactions;Peptides;pharmacologic;Physiological;Population Dynamics;Property;protective effect;protein purification;Proteins;Protocols documentation;Resistance;Role;Sampling;Severity of illness;single nucleus RNA-sequencing;Slice;small molecule;Structure;Synapses;System;Toxic effect;Variant;vascular contributions;Vascular Diseases;Vascular System

PROJECT_TITLE: Role of Fibrinogen in Alzheimer's Disease

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: OVERALL COMPONENT NARRATIVE Atrial fibrillation (AF) is an increasing clinical problem, and despite identification of strong genetic connections, genetic findings have yet to achieve clinical applications. This Program aims to advance AF genomic discoveries toward the bedside, focusing on genes to mechanisms, genes to drugs, and interactions of genes with metabolism and environment. The 4 highly integrated projects and cores aim to bridge basic research in AF towards clinically actionable therapies.

PI_NAMEs: CHUNG, MINA KAY (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: 4q25;Ablation;Address;Adult;Age;Amines;Animal Model;Arrhythmia;Artificial Intelligence;Atrial Fibrillation;Back;Basic Science;biobank;candidate identification;Cardiac;Cardiac Myocytes;cardiac tissue engineering;causal variant;Cell model;Cell Nucleus;Cells;Cheese;Choline;Clinical;clinical application;clinically actionable;Collaborations;comorbidity;Data;Databases;Diet;dietary;drug discovery;drug repurposing;Drug Targeting;drug testing;egg;Electrophysiology (science);Engineering;Environment;Fibrosis;Functional disorder;Gene Expression;Gene Expression Regulation;gene interaction;Gene Targeting;Genes;Genetic;Genetic Risk;genome resource;genome wide association study;genomic data;genomic locus;Genomics;Goals;gut microbiome;gut microbiota;Heart Atrium;Human;In Vitro;in vivo;Incidence;Individual;induced pluripotent stem cell;Inflammasome;Inflammatory;inhibitor;insight;Intervention;Knowledge;Left;Link;Meat;Metabolic;Metabolism;metabolomics;Methods;Mitochondria;mitochondrial dysfunction;Molecular;mouse model;multidisciplinary;Mus;Muscle Cells;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;nutrition;Obesity;Oxides;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiology;Prevalence;prevent;Prevention;Preventive;programs;Proteomics;Pulmonary veins;Recording of previous events;Research;Research Personnel;Risk;Risk Factors;risk variant;RNA Sequences;Role;single nucleus RNA-sequencing;STK11 gene;stressor;Stroke;Study models;synergism;Systems Biology;Testing;Therapeutic;therapeutic evaluation;Thinness;Tissue Model;Tissues;transcriptome sequencing;Transgenic Mice;Translating;Translations;Variant

PROJECT_TITLE: Atrial Fibrillation Post-GWAS: Mechanisms to Treatment


PROJECT_TERMS: Acceleration;Accounting;Address;Animal Experimentation;Animals;Atrial Fibrillation;Awareness;Back;Basic Science;cardiac tissue engineering;Cell model;Cells;Clinic;Clinical;Collaborations;Communication;Data;design;Documentation;Electrophysiology (science);Ensure;Environment;Experimental Designs;experimental study;Funding;gene interaction;Generations;Genes;Genetic;genome wide association study;Genomics;Goals;Grant;Heart Atrium;Human;human subject;Human Subject Research;Information Dissemination;Leadership;Link;Maintenance;Manuscripts;meetings;Mentors;Metabolism;Monitor;mouse model;Mus;National Heart, Lung, and Blood Institute;Office of Administrative Management;operation;Oral;Participant;Performance;Pharmaceutical Preparations;Phenotype;Preparation;Preventive;professional atmosphere;professor;programs;Progress Reports;Reporting;Reproducibility;Research;Research Personnel;Resources;responsible research conduct;Schedule;Science;Scientist;Services;sex as a biological variable;synergism;Systems Biology;Therapeutic;Time;Translating;Visit;Work;Writing

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Women's Health Research

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Gender inequities are prevalent and persistent in the biomedical sciences, and workforce inequities have worsened over the past 18 months as the COVID-19 pandemic has disproportionately impacted on female, minority, and early career investigators. To reduce pandemic-related effects and minimize worsening inequities long-term, we propose a randomized study to evaluate a novel, scalable, and theory-based professional coaching intervention called iACTIVATE directed at early career female investigators. We will test whether this coaching program can lead to improved self-efficacy, research productivity, and career advancement as well as examine potential mechanisms for outcomes; if successful, the novel program will be ready to scale to the broader biomedical research workforce nationally.

PI_NAMEs: VOLERMAN, ANNA  (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Accountability;Achievement;Address;Administrator;Adopted;Affect;Applications Grants;Area;Award;Biomedical Research;burnout;Businesses;career;Career Choice;Career Mobility;Caring;Cognitive;Competence;cost;COVID-19 pandemic;Data;Development;Discrimination;Disproportionately impacts women;Diverse Workforce;Early Intervention;early-career faculty;Environment;experience;Faculty;Family member;Feedback;Female;Fostering;Funding;Funding Agency;Gender;Grant;Health;Home;improved;Individual;Inequity;Institution;Intervention;Interview;Leadership;Learning;Life;Literature;long-standing disparities;Measures;Medicine;men;Methods;Minority;Motivation;nonbinary;novel;Outcome;pandemic disease;pandemic impact;Participant;Performance;Personal Satisfaction;personalized approach;Persons;Population Heterogeneity;Process;Productivity;Professional Organizations;programs;Publications;Publishing;Quarantine;racism;Randomized;randomized trial;Randomized, Controlled Trials;Reaction;recruit;Research;Research Personnel;Research Project Grants;Resources;Risk;Sampling;Science;Scientific Advances and Accomplishments;Scientist;Self Efficacy;Self Perception;skills;social;Social support;Study Section;success;Surveys;Testing;theories;Time;tool;Training;trial comparing;Underrepresented Populations;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: iACTIVATE: Investigators Advancing via Coaching at the Transition to Independence: a Value-Adding Team Experience


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Human

PI_NAMEs: VAN WAGONER, DAVID R (contact)

PROJECT_TERMS: Age;American;Applications Grants;Arrhythmia;Atrial Fibrillation;Back;Cardiac Myocytes;cardiac tissue engineering;Cellular Structures;Citrate (si)-Synthase;clinical application;cost;cost effective;Data;Development;Diabetes Mellitus;Doctor of Philosophy;Drug Exposure;Elderly;Electric Countershock;embryonic stem cell;Ensure;Environment;Equipment;Evaluation;experience;Experimental Models;experimental study;Fibroblasts;Functional disorder;gene interaction;Generations;Genes;Genetic;genome wide association study;Genomics;Genus Hippocampus;Goals;Health;Heart;Heart Atrium;Human;Human Resources;Hypertension;in vivo;Individual;induced pluripotent stem cell;innovation;Intervention;Knowledge;Laboratories;Lead;Left;lifetime risk;Maintenance;Measures;Metabolic;Metabolic stress;Metabolism;Methodology;Methods;Mitochondria;Mitochondrial DNA;Modeling;Molecular;Monitor;Morphology;Mus;Muscle Cells;novel;Obesity;Pharmaceutical Preparations;Phenotype;pluripotent stem cell differentiation;Population;Preventive;Procedures;Production;Program Research Project Grants;programs;Property;Protocols documentation;Reproducibility;Research Institute;Research Personnel;Resolution;Respiration;Risk Factors;RNA;Scientist;service organization;Services;Shock;Smoking;Structure;Subcellular structure;Supporting Cell;Techniques;Technology;Testing;Therapeutic;therapeutically effective;Tissues;Translating;treatment program;Ventricular

PROJECT_TITLE: Engineered Heart Tissue and Atrial Phenotyping Scientific Core 1


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: LA JOLLA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative. Human ALIX is involved in many essential cellular and membrane scission processes. This proposal aims to understand in molecular detail the interdependence between ALIX polymerization, its posttranslational modifications, including tyrosine phosphorylation and ubiquitination, and its cellular and membrane functions.

PI_NAMEs: DESHMUKH, LALIT  (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Affect;Amyloid Fibrils;Apoptosis;beta pleated sheet;Biology;Cell membrane;Characteristics;endosome membrane;Human;insight;Kinetics;Label;late endosome;Liquid substance;Mammalian Cell;Mediating;Membrane;Membrane Lipids;Methods;milligram;Molecular;novel;Pathway interactions;Phase;Phosphorylation;Phosphorylation Inhibition;Phosphotransferases;Physical condensation;polymerization;Polymers;Post-Translational Protein Processing;Process;Production;Proline-Rich Domain;Protein Dephosphorylation;Proteins;recruit;Regulation;Resolution;Role;Sampling;Signal Transduction;Site;Time;Tyrosine;Tyrosine Phosphorylation;Ubiquitin;Ubiquitination;Virus

PROJECT_TITLE: The Functional Interplay Between Phase Separation, Fibrillization, and Posttranslational Modifications of ALIX

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Human

PI_NAMEs: LAURITA, KENNETH  (contact)

PROJECT_TERMS: Action Potentials;Age;Applications Grants;Arrhythmia;Atrial Fibrillation;cardiac tissue engineering;cardiovascular risk factor;Cell Physiology;Clinical;clinical application;Complement;cost effective;cost efficient;Critiques;Data;Data Collection;design;Diagnosis;Dissociation;Doctor of Philosophy;drug discovery;Dyes;Electrocardiogram;Electrophysiology (science);Ensure;Equipment;Experimental Designs;experimental study;Fluorescence Microscopy;Functional disorder;Fura-2;Genetic;genome wide association study;Genomics;Goals;Heart;Heart Atrium;Human Resources;In Situ;Incidence;Individual;innovation;Ion Channel;Kinetics;Lead;Left atrial structure;Link;Maps;Measures;Membrane Potentials;Metabolic;Methodology;Methods;Mitochondria;mitochondrial membrane;Molecular;Monitor;mortality;Mus;Muscle Cells;Obesity;Optics;Organizational Efficiency;Outcome;patch clamp;Perfusion;Phenotype;Population;Predisposition;Preparation;Preventive;Procedures;Production;Program Research Project Grants;programs;Property;Reactive Oxygen Species;Regulation;Reproducibility;Research Institute;Research Personnel;Resolution;response;Right atrial structure;Risk;Sampling;Scientist;Services;stressor;Stroke;System;Techniques;Technology;Testing;Therapeutic;therapeutically effective;voltage;voltage sensitive dye

PROJECT_TITLE: Electrophysiology Scientific Core 2


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Narrative Because there are no studies comparing experiences in cancer care between cisgender, heterosexual cancer patients and sexual and gender minority cancer patients, first, we will conduct in depth interviews to identify key concerns related to recruitment. Then, we will test recruitment methods and conduct the first study to identify what would help or hinder these small populations to participate in cancer research.

PI_NAMEs: ROSSER, B R SIMON  (contact)

PROGRAM_OFFICER_NAME: BERRIGAN, DAVID

PROJECT_TERMS: Acceleration;Accounting;Address;advanced disease;Advertising;Affect;Alcohol abuse;anti-cancer research;Area;Attitude;Belief;Bisexual;Cancer Burden;cancer care;cancer health disparity;Cancer Patient;cancer risk;Cancer Survivor;cancer therapy;cancer type;care delivery;Caring;cis-female;cis-male;cisgender;Clinic;Clinic Visits;Comparative Study;comparison group;Computerized Medical Record;Conceptions;Congresses;cost;Cybersex;Data;Data Sources;design;Development;Discrimination;effectiveness testing;Ethnic Origin;evidence base;Exclusion;experience;Face;Gays;Gender;Gender Identity;gender minority;gender minority group;gender minority health research;health disparity;Heterosexuals;HIV;informant;intersectionality;Intervention Trial;Interview;Lesbian Gay Bisexual Transgender;Literature;male;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;men;Mental Health;Methodology;Methods;minority stress;neglect;nonbinary;novel;Outcome;patient population;Patient Recruitments;patient stratification;Patients;Performance;Persons;Population;prevent;Primary Prevention;Professional Organizations;Protocols documentation;Race;recruit;Rehabilitation therapy;Reporting;Research;Research Personnel;research study;Sampling;satisfaction;sex;Sex Orientation;Sexual and Gender Minorities;sexual minority;sexual minority group;sexual minority men;sexual minority women;Shapes;Site;Smoking;social;social stigma;Social support;sociodemographics;Structure;Subgroup;success;Surveys;Survivors;Telephone;Testing;theories;Time;transgender;Underserved Population;United States National Institutes of Health;willingness;Woman;women patients;Work;Workload

PROJECT_TITLE: Testing Effective Methods to Recruit Sexual and Gender Minority Cancer Patients for Cancer Studies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-V(02)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome

PI_NAMEs: BARNARD, JOHN  (contact)

PROJECT_TERMS: Age;Arrhythmia;Atrial Fibrillation;Biological Assay;cardiovascular risk factor;Cell Nucleus;cell type;Clinical;clinical application;Data;Detection;Diagnosis;differential expression;Disease;Doctor of Philosophy;drug discovery;experience;flexibility;Gene Expression;Genes;Genetic;genome wide association study;Genomics;Goals;Heart Atrium;Human Resources;Incidence;Kinetics;Knowledge;Lead;Metabolic;metabolomics;Modeling;Molecular;mortality;network models;Obesity;Outcome;Population;power analysis;Process;Proteins;Proteomics;Reproducibility;Research Institute;Research Personnel;Risk;RNA;RNA Processing;Sample Size;Sampling;Services;single nucleus RNA-sequencing;skills;Stroke;Study models;success;Systems Biology;Therapeutic;therapeutically effective;trait;transcriptome sequencing;transcriptomics;Visualization;Work

PROJECT_TITLE: Network and Systems Biology Scientific Core 3


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: Chicago

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative The Chicago ARea Excellence in Education & Research (CAREER) program is committed to training postdoctoral scholars as researchers, focused on cutting-edge biomedical science relevant to human health, and as teachers, with an emphasis on preparing trainees to educate diverse and underserved populations. Collaboration between UIC and Governors State University serves as the foundation for this program and incorporates team-based mentoring from both schools, along with career development, to generate outstanding future faculty. Postdoctoral scholars trained by CAREER will therefore be well-prepared for careers in academia and as such will have a significant impact on training the future generations of students.

PI_NAMEs: BURDETTE, JOANNA E;NONN, LARISA  (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Academia;Area;Asian Americans;Cancer Center;career;career development;Chicago;Cities;cohort;Collaborations;college;Communities;Competence;Course Content;design;Education;Educational Curriculum;Educational process of instructing;Educational workshop;Ensure;experience;Faculty;Fostering;Funding;Goals;Health;Hispanic;Illinois;Individual;Inosine Diphosphate;Institution;Learning;lectures;Medicine;Mentors;Minority;Mission;National Institute of General Medical Sciences;Native Americans;Pacific Island Americans;Pharmacy facility;Population Heterogeneity;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;programs;Publications;recruit;Research;research and development;Research Personnel;Research Support;Schools;Scientist;skills;Structure;Students;suburb;teacher;Training;Training Programs;undergraduate student;Underrepresented Minority;Universities;university student

PROJECT_TITLE: IRACDA at University of Illinois at Chicago

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

PI_NAMEs: SMITH, JONATHAN D (contact)

PROJECT_TERMS: 10q22;Actins;Action Potentials;Address;Adult;Affect;Age;analysis pipeline;Atrial Fibrillation;auricular appendage;Binding;biracial;Breeding;Calcium;Cardiac Myocytes;causal variant;Cell Nucleus;Cessation of life;Chromosomes;Clinical;cohort;Collaborations;Complex;Cytoplasm;Cytoskeleton;Data;Dedications;design;Development;Doctor of Philosophy;Dominant-Negative Mutation;drug candidate;Electrophysiology (science);Engineering;FDA approved;functional genomics;gain of function;Gene Expression;Gene Expression Regulation;Genes;genetic association;genetic variant;genome wide association study;genomic locus;Goals;Heart Atrium;Heart failure;heart function;Heritability;Human;Human Genome;human stem cell-derived;human stem cells;improved;in vivo;Incidence;Individual;insight;Ion Transport;knock-down;Knockout Mice;Knowledge;Left;Left atrial structure;Linkage Disequilibrium;Metabolism;Molecular;Morphology;mouse model;novel;novel therapeutic intervention;Nuclear;Nuclear Envelope;Obesity;overexpression;Pathway interactions;Pharmaceutical Preparations;Physiology;Predisposition;Program Description;programs;Protein Isoforms;Proteins;Quantitative Trait Loci;Research;response;Risk;risk variant;Role;Sarcoplasmic Reticulum;Single Nucleotide Polymorphism;Sinus;stem cell differentiation;Stroke;Structure;Tamoxifen;Testing;Therapeutic;therapeutic evaluation;Tissues;Transcript;Transcription Initiation Site;transcriptome;transcriptome sequencing;transcriptomics;Transgenic Mice;Variant;Ventricular;Work

PROJECT_TITLE: Project 1 - Genes to Function: Causal Genes and their Roles in Cardiomyocyte and Atrial Physiology


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Heart Disease;Nutrition;Physical Activity

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Patients who have heart failure, or the inability of the heart to pump blood efficiently to the body, have reduced quality of life, exercise intolerance, and are at greater risk for poor outcomes including death. This proposal seeks to define a novel pathway of treatment in patients with heart failure using an alternative energy source (ketone bodies). If beneficial, the results of our study may inspire larger studies and trials of such therapy in patients with heart failure in order to improve symptoms, quality of life, and ultimately reduce morbidity and mortality from heart failure.

PI_NAMEs: SELVARAJ, SENTHIL  (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Accounting;Activities of Daily Living;Acute;acylcarnitine;Affect;Aldosterone;Angiotensins;animal data;Award;Basic Science;Bioenergetics;Biological Markers;Blood flow;blood pump;Blood Vessels;carbohydrate metabolism;Carbohydrates;Cardiac;Cardiac Output;Cardiopulmonary;Cardiovascular system;career;Cell Respiration;Cessation of life;Chemicals;Clinic;Clinical;Clinical Data;Clinical Research;Coupled;Cross-Over Trials;Data;Dose;Drug Kinetics;Echocardiography;Energy-Generating Resources;Environment;Esters;Exercise;exercise capacity;exercise intolerance;Exercise Test;Exercise Tolerance;exhaustion;experience;Fatty Acids;Functional disorder;Funding;Future;Gases;Glucose;Glycogen;Goals;healthy volunteer;Heart;Heart failure;heart failure with reduced ejection fraction;hemodynamics;Human;Impairment;improved;Infusion procedures;inhibitor;insight;Intervention;Intramuscular;Ketone Bodies;Ketones;Ketosis;Left Ventricular Remodeling;Literature;Lower Extremity;Magnetic Resonance;Magnetic Resonance Imaging;Measurement;Measures;Medical;Mentorship;Metabolic;metabolic imaging;Metabolism;metabolomics;Mitochondria;Molecular;Morbidity - disease rate;mortality;Muscle;Myocardial;Myocardial dysfunction;Myocardium;Nonesterified Fatty Acids;novel;novel therapeutics;Nutraceutical;optical imaging;Outcome;Output;oxidation;Oxygen;Oxygen Consumption;Participant;Pathologic;Pathway interactions;Patients;Pennsylvania;Perfusion;Peripheral;Persons;phenomics;Phenotype;Physiological;placebo controlled trial;Placebos;Plasma;Population;Positioning Attribute;pre-clinical;preservation;Production;Protocols documentation;Quality of life;randomized trial;Renin;Research;Research Personnel;Residual state;respiratory;Risk;Safety;Science;Skeletal Muscle;Sodium;Source;stable isotope;Standardization;Sympathetic Nervous System;symporter;symptomatic improvement;Symptoms;Syndrome;Techniques;Therapeutic;Time;tonometry;Training;Translational Research;treatment strategy;Universities;vasoconstriction;Ventricular Dysfunction;Work;Workload

PROJECT_TITLE: Dissecting the Ketone Metabolic Axis in Heart Failure with Reduced Ejection Fraction

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome;Nutrition;Obesity

PROJECT_TERMS: Aging;Alcohols;Arrhythmia;Atrial Fibrillation;Atrial Function;Attenuated;Cardiac Myocytes;cardiac tissue engineering;Cardiovascular system;Cells;Cellular Membrane;Chronic;Clinical;Collaborations;Consumption;Contractile Proteins;Coronary heart disease;cytokine;Development;diet-induced obesity;Disease;DNA Damage;Doctor of Philosophy;drug candidate;Drug Modulation;Drug Targeting;Electrocardiogram;Electrophysiology (science);Endothelin-1;Ethanol;Etiology;Exertion;Exposure to;Extracellular Matrix;Feedback;Fibroblasts;Functional disorder;Generations;Genes;Genetic Transcription;genome wide association study;Goals;Heart Atrium;Heart failure;hemodynamics;Heterogeneity;Heterozygote;High Fat Diet;Human;human induced pluripotent stem cells;Hypertension;Impairment;improved;in vitro Model;Inflammasome;Inflammatory;insight;Intervention;Ion Channel;Isoproterenol;Knowledge;Left;Link;lipid metabolism;Lipids;Maps;Membrane Potentials;Messenger RNA;Metabolic;Metabolic Pathway;Metabolic stress;Metabolic syndrome;Metabolism;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial metabolism;mitochondrial permeability transition pore;Modeling;mouse model;Mus;novel strategies;novel therapeutic intervention;Obese Mice;Obesity;Optics;Oxidants;Oxidation-Reduction;Oxidative Phosphorylation;Palmitates;Pathologic;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Physiology;Preclinical Testing;preservation;Production;protective effect;Proteomics;Reactive Oxygen Species;Research Personnel;resilience;response;Risk;Risk Factors;Role;single nucleus RNA-sequencing;Sinus;Sleep Apnea Syndromes;Stress;stressor;stroke risk;synergism;Testing;Thinness;Time;Tissue-Specific Gene Expression;Tissues;Transcriptional Regulation;transcriptome;transcriptome sequencing;transcriptomics;Transgenic Mice

PROJECT_TITLE: Genes and Metabolism: Targeting Mitochondrial Dysfunction in Atrial Fibrillation


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: SHERMAN OAKS

ORG_NAME: TRETHERA CORPORATION

PHR: PROJECT NARRATIVE Acute disseminated encephalomyelitis (ADEM) is an autoimmune disease driven by activated lymphocytes with significant morbidity and mortality and no FDA-approved therapy for its treatment. Our company, Trethera, is developing a novel small molecule drug, TRE-515, to treat ADEM by targeting a pathway required for lymphocyte proliferation. In the proposed project, we will conduct critical preclinical work to further evaluate how TRE-515 affects immune cell development and interacts with other drugs used to treat ADEM.

PI_NAMEs: SCHULTZ, KENNETH  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: 8 year old;Activated Lymphocyte;Acute;Acute Disseminated Encephalomyelitis;Address;Adolescence;Adolescent;Adrenal Cortex Hormones;Adult;Adverse effects;Adverse event;Affect;Age;Antigens;Ataxia;Autoimmune Diseases;autoreactive T cell;Award;B Cell Proliferation;B-Cell Activation;B-Lymphocytes;Behavioral;Bone Marrow;Cancer Patient;cancer therapy;CD4 Positive T Lymphocytes;cell type;Cells;Central Nervous System;Cessation of life;Child;Clinic;Clinical;Clinical Trials Design;Coma;Complete Blood Count;Cytometry;Data;Death Rate;Defect;Deoxycytidine;Deoxycytidine Kinase;Deoxyribonucleosides;Deoxyribonucleotides;Development;Dexamethasone;Disease;DNA biosynthesis;dosage;Dose;Drug Evaluation;Drug Targeting;Drug usage;Enzymes;Event;Experimental Autoimmune Encephalomyelitis;FDA approved;Fever;Gene Mutation;Grant;Human;Hypotension;Immune;immune cell infiltrate;Immune system;Immunization;improved outcome;in vivo;Infection;Intravenous;kinase inhibitor;Knock-out;Lead;lymph nodes;Lymphocyte;lymphocyte proliferation;Measures;Mediating;Medical;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Myelin;novel;novel therapeutics;nucleoside inhibitor;old mice;Orphan Drugs;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;Plasma;Population;Positron-Emission Tomography;potential biomarker;pre-clinical;preclinical study;Prognosis;prophylactic;radiotracer;Rare Diseases;Recovery;Regulatory T-Lymphocyte;Serious Adverse Event;side effect;Small Business Technology Transfer Research;small molecule;small molecule inhibitor;Solid Neoplasm;Spleen;standard of care;Steroids;success;symptomatic improvement;Symptoms;T-Cell Activation;T-Cell Development;T-Cell Proliferation;T-Lymphocyte;Tachycardia;Testing;Therapeutic;Thymus Gland;Time;Toxic effect;Unconscious State;Virus Diseases;Work

PROJECT_TITLE: Development of a Novel, Targeted Small Molecule Inhibitor of the Nucleoside Salvage Pathway to Treat Acute Disseminated Encephalomyelitis (ADEM)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-P(11)]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome;Precision Medicine;Prevention

PROJECT_TERMS: Ablation;Algorithms;Artificial Intelligence;Atrial Fibrillation;auricular appendage;Bass;biobank;candidate validation;cardiac tissue engineering;Cell model;Cell Nucleus;cell type;Cells;Cellular Stress;Cessation of life;Clinical;comorbidity;Data;Databases;Development;Diagnosis;Disease;Disease Progression;Doctor of Philosophy;drug candidate;Drug Combinations;drug development;drug repurposing;Drug Targeting;drug testing;Electrophysiology (science);Environment;Environmental Impact;Fibroblasts;Gene Expression;gene regulatory network;Genes;Genetic;genetic risk factor;genome wide association study;Genomics;Goals;Heart Atrium;Human;Human Engineering;human interactome;insight;Lead;Left;Measures;Mediating;Medical;Metabolic;metabolomics;Methodology;Modeling;Molecular;Molecular Disease;mouse model;multimodality;Multiomic Data;Mus;Network-based;novel;Outcome;Pathway interactions;Patients;personalized medicine;Pharmaceutical Preparations;Pharmacotherapy;Population;precision medicine;preclinical efficacy;prevent;Prevention;Process;Prognosis;programs;Proteins;Proteomics;Recurrence;research clinical testing;response;risk variant;side effect;single nucleus RNA-sequencing;Stress;stressor;success;Systems Biology;Testing;Therapeutic;therapeutic target;Time;Tissue Model;Tissues;transcription factor;transcriptome sequencing;transcriptomics;trial design;Validation

PROJECT_TITLE: Project 3 Genes to Omics-Informed Drugs: Drug Repositioning and Testing to Prevent AF Progressions


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome;Microbiome;Nutrition;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

PI_NAMEs: KOETH, ROBERT ALDEN (contact)

PROJECT_TERMS: Ablation;acquired factor;Action Potentials;Acute;Adipose tissue;Alcohol abuse;Amines;Animal Model;Anti-Arrhythmia Agents;Antibiotics;Anticoagulants;Anticoagulation;Atherosclerosis;Atrial Fibrillation;Blood Platelets;Cardiac Myocytes;cardiac tissue engineering;Cardiovascular system;Catabolism;Catheters;Cheese;Choline;Chronic;Data;Diet;dietary;egg;Electrophysiology (science);Endothelium;Enzymes;Epidemiology;Event;experimental study;fecal transplantation;Fibroblasts;Fibrosis;Flavins;Functional disorder;Genes;genome wide association study;gut microbiome;gut microbiota;Heart;Heart Atrium;Heart failure;Human;Hyperactivity;In Vitro;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;Inflammasome;Inflammation;Inflammatory;inhibitor;insight;Intervention;Ischemic Stroke;Left;Link;Liver;Longitudinal cohort;Maps;marenostrin;Meat;Membrane Potentials;Metabolic;Metabolism;microbiome;microbiota transplantation;Mitochondria;Mixed Function Oxygenases;Monitor;Morbidity - disease rate;mortality;mouse model;Mus;Muscle Cells;novel;nutrition;Obesity;Optics;Oxides;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;Plasma;Predisposition;prevent;Procedures;Production;Reactive Oxygen Species;Reporting;Research Personnel;Risk;Risk Factors;Role;Source;Stroke;stroke risk;Thrombosis;tool;trait

PROJECT_TITLE: Genes and Nutrition: Dietary Choline, the Gut Microbiota, and Atrial Fibrillation


ADMINISTERING_IC: DA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: The HIV and opioid epidemics intersect, impacting millions of people worldwide. Antiretroviral therapy (ART) has improved and extended the lives of people with HIV, PWH. However, milder chronic HIV associated neurocognitive impairments (NCI) of varying severity known as mild HAND or HIV-NCI persist. HIV-NCI affect 15-40% of PWH and because they persist for life, can worsen with age, and affect adherence to medications, they can significantly reduce quality of life and increase mortality risk. NCI progression appears to correlate with increased HIV in the CNS despite ART. Ongoing low level neuroinflammation also mediates HIV-NCI. Many PWH have opioid use disorder, a comorbidity in PWH that can potentially exacerbate NCI. Our exciting and novel results suggest that buprenorphine, an established opiate substitution therapy (OST) that is used to treat addiction and withdrawal, prevents/reverses cognitive impairment in EcoHIV infected mice, by reducing inflammatory HIV infected/uninfected monocyte entry into the brain, limiting viral seeding of CNS reservoirs, and thus the neuroinflammatory and viral neurotoxic activities that mediate HIV-neurocognitive impairment. Our proposed studies are to characterize the mechanisms by which buprenorphine can mitigate cognitive impairment in PWH with and without OUD. We hypothesize that the positive impact of buprenorphine on HIV- NCI is mediated though MOR and KOR, and specifically their expression on monocytes and myeloid cells. For our innovative studies we will use human monocytes HIV infected in vitro, the Eco-HIV infected mouse model, and PBMC from three different groups of PWH on ART who will undergo cognitive testing at the time of blood draw: 1) PWH taking no opioids or opioid antagonists, 2) PWH taking buprenorphine, and 3) PWH taking prescription opioids.

PI_NAMEs: BERMAN, JOAN WEINBERGER (contact);KELSCHENBACH, JENNIFER L;VOLSKY, DAVID J

PROGRAM_OFFICER_NAME: MANDLER, RAUL N

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;addiction;Address;Adherence;Affect;Age;Agonist;Animal Model;antagonist;antiretroviral therapy;Biology;Blood;Blood - brain barrier anatomy;blood-brain barrier crossing;Brain;Buprenorphine;buprenorphine treatment;CCL2 gene;CD14 gene;Cells;Central Nervous System Diseases;chemokine;Chronic;cognitive function;cognitive testing;Communicable Diseases;comorbidity;Data;Dementia;Development;Disease;DNA;experience;FCGR3B gene;Funding;Gene Modified;Generations;Hand;HIV;HIV Infections;HIV therapy;HIV-associated neurocognitive disorder;Human;Impaired cognition;improved;In Vitro;in vivo;Individual;Inflammation;Inflammatory;innovation;kappa opioid receptors;Laboratories;Lead;Life;Link;Macrophage;Malignant Neoplasms;Mediating;Mediator;Methadone;migration;Modeling;monocyte;mortality risk;mouse model;mu opioid receptors;Mus;Myeloid Cells;neuroAIDS;Neurocognitive Deficit;neuroinflammation;Neuropathogenesis;Neuropsychology;neurotoxic;Neurovirology;New York City;novel;Opioid;opioid abuse;opioid agonist therapy;Opioid Antagonist;opioid epidemic;Opioid Receptor;Opioid replacement therapy;opioid use disorder;Outcome;overdose risk;Peripheral;peripheral blood;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Physicians;Pre-Clinical Model;Prediction of Response to Therapy;Predisposition;prescription opioid;prevent;Process;Property;Quality of life;receptor;Research;response;Role;Safety;Scientist;Severities;side effect;Signal Transduction;Specialist;Synapses;Therapeutic;Time;Viral;Viral Load result;Withdrawal

PROJECT_TITLE: Effect of buprenorphine on monocytes in the context of neuroAids and opioid abuse

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: DAVIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Opioids cause many changes in the brain, some of which underlie substance use disorder, but most of which merely reflect exposure to drug, including benefits such as pain relief. Identifying the neural substrates underlying the pathologic side effects of opioid use, and disentangling them from the beneficial effects of opioid drugs in particular, will be critical for intervening in the opioid crisis. Here we will assess cell type specific changes in gene expression that occur in mice that do and do not develop opioid dependence.

PI_NAMEs: NORD, ALEXANDER ;WHISTLER, JENNIFER L (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Abstinence;Acute;addiction;Adult;Affect;Affective;Agonist;Analgesics;Animals;Arrestins;Behavior;Behavioral;Biology;Brain;Cell Nucleus;cell type;Cells;Characteristics;Clinical;Cognitive;Computing Methodologies;Custom;Data;Data Set;Decision Making;Dependence;Derivation procedure;Diagnosis;Dissociation;Distress;Dose;drug abstinence;Drug abuse;Drug Exposure;Drug Modelings;Endocytosis;Endorphins;Engineering;Enkephalins;Essential Drugs;Exhibits;Experimental Designs;experimental study;Exposure to;Failure;flexibility;Fluorescence;G-Protein-Coupled Receptors;Gene Expression;Gene Expression Profile;Genetic Transcription;Genotype;Goals;GTP-Binding Proteins;Human;Impairment;Individual;insight;Knock-in Mouse;Ligands;Methods;Modeling;Molecular;Morphine;Morphine Dependence;mu opioid receptors;Mus;mutant;neural;Neurons;Opiate Addiction;Opioid;opioid abuse;opioid epidemic;opioid exposure;opioid use;Pain;pain relief;Pathologic;Pathology;Patients;Pharmaceutical Preparations;Pharmacology;Phenotype;Physical Dependence;Population;Positioning Attribute;pre-clinical research;preclinical study;Property;protein activation;Proteins;receptor;Receptor Signaling;Recovery;recruit;Recycling;Regimen;Relapse;Research;Resolution;response;Rewards;Risk;RNA;Saline;Sampling;side effect;Signal Transduction;Signaling Protein;single nucleus RNA-sequencing;single-cell RNA sequencing;Sorting;Substance Use Disorder;Synapses;Time;Tissue-Specific Gene Expression;Tissues;Titrations;tool;Transcript;treatment duration;Ventral Tegmental Area;Weaning;Wild Type Mouse;Withdrawal;Work

PROJECT_TITLE: Single cell RNA profiles of opioid dependence

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Microbiome;Prevention

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The proposal focuses on understanding how a loss-of-function genetic variation of an enzyme called DUOX2 that controls gut bacteria within our GI tract could lead to early stages of disease development in IBD. A more in-depth investigation of a defect in DUOX2 activity is expected to uncover the overgrowth of disease-triggering gram-negative bacteria able to cause a breach in the intestinal barrier triggering the early stages of GI disorders including IBD but also other diseases associated with similar changes in gut microbiota such as colon cancer, obesity, diabetes, fatty liver disease, and metabolic syndromes. Because our study addresses an early event common to a number of diseases, the successful completion of our project may have significant implications for disease prevention.

PI_NAMEs: GRASBERGER, HELMUT F;KAO, JOHN Y (contact)

PROGRAM_OFFICER_NAME: PAWLIKOWSKA, LUDMILA SYLWIA

PROJECT_TERMS: Ablation;Address;Alleles;autocrine;bacterial fitness;Biopsy;Cells;Chronic;Colitis;Colon Carcinoma;Defect;Development;Diabetes Mellitus;Disease;disorder prevention;dysbiosis;Early Diagnosis;Early treatment;Enterocytes;Enzymes;Epithelium;Event;fatty liver disease;Gastrointestinal tract structure;Genes;Genetic;genetic association;Genetic Epistasis;genetic variant;Genetic Variation;genome-wide;germ free condition;Gnotobiotic;Gram-Negative Bacteria;Granulocyte-Macrophage Colony-Stimulating Factor;Growth;gut bacteria;gut microbes;gut microbiota;Gut Mucosa;Healthcare;Homeostasis;Homologous Gene;Host Defense;Human;Hydrogen Peroxide;IL17C gene;Immune;Immune response;improved;In Vitro;Individual;Inflammatory;Inflammatory Bowel Diseases;Integration Host Factors;interleukin-17C;interleukin-22;intestinal barrier;Investigation;Link;loss of function;M cell;man;Measures;Mediating;Metabolic syndrome;Microbe;microbial colonization;microbiota;Modeling;Molecular;Morbidity - disease rate;Mucosal Immunity;Mucous body substance;Mucous Membrane;multiple omics;Mus;NADPH Oxidase;new therapeutic target;novel;novel strategies;Obesity;Onset of illness;Outcome;overexpression;Oxidases;Oxidation-Reduction;pathobiont;Pathogenesis;Pathogenicity;Pathway interactions;Patients;pharmacologic;Phenotype;Plasma;Population;Population Attributable Risks;pre-clinical;Predisposition;prevent;preventive intervention;Production;Prognosis;Proteins;reconstitution;Regulation;Research;Resources;Risk;Risk Factors;risk variant;Role;Signal Transduction;System;Testing;Therapeutic Intervention;Variant;virulence gene;Work

PROJECT_TITLE: Mechanisms of Duox2 variants in the pathogenesis of preclinical IBD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-P(03)]


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Biological networks are often spatially organized to ensure that reactions inside cells occur at the right place and time, particularly in fundamental processes like cell signaling and genome regulation. We will systematically explore the relationship between spatial organization and function in these systems with quantitative biochemical assays, structural methods, cell-based studies, and new synthetic biology tools. This approach will enable us to understand underlying regulatory principles and how to intervene when these processes are misregulated in human diseases.

PI_NAMEs: ZALATAN, JESSE GEORGE (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Acceleration;Address;Adopted;Affect;Biochemical;biochemical model;Biochemical Process;Biochemical Reaction;Biological;Biological Assay;Biological Models;Cell Physiology;Cells;cellular engineering;Complex;CRISPR/Cas technology;design;DNA;Engineering;Environment;Gene Expression;Gene Order;Genome;human disease;Kinetics;Knowledge;Mediating;Methods;Modeling;Molecular;Molecular Conformation;Outcome;Pathway interactions;Phosphoric Monoester Hydrolases;Phosphotransferases;Play;Process;Proteins;Reaction;Regulation;Role;scaffold;Scaffolding Protein;Signal Transduction;Signaling Protein;Site;Structure;Structure-Activity Relationship;synthetic biology;System;Testing;therapeutic target;therapeutically effective;three dimensional structure;Time;tool

PROJECT_TITLE: Spatial Organization in Biochemical Reaction Networks


ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA AGRICULTURAL AND MECHANICAL UNIV

ORG_STATE: FL

PHR: Project Narrative Despite many recent advances to diversify the STEM workforce, many groups remain unequally and unjustly represented in the biomedical sciences research workforce, with an increase in underrepresentation in matriculation to 4-year colleges and universities from community college. The Bridges to the Baccalaureate Research Training Program at Florida A&M University aims to provide structured, evidence-based approaches in the recruitment, training, and graduation of talented and motivated underrepresented undergraduate students from Tallahassee Community College and Florida A&M University. Implementation of such approaches within a partnership between a community college with a high underrepresented student population and Florida’s only state-funded Historically Black College and University (HBCU), will equip trainees and students at both institutions with the technical, operational, and professional skills required for careers in the biomedical research workforce, thereby aiding in diversification of the STEM workforce, and enabling graduates to address the nation’s biomedical, behavioral, and clinical research needs.

PI_NAMEs: DARLING-REED, SELINA FAITH (contact);JONES, ANTHONY

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: African American population;African American student;Bachelor's Degree;Biomedical Research;bridge to the baccalaureate;Capital;career;Career Choice;career development;Career Exploration;Caring;Cognitive;cohort;Communities;community college;Decision Making;design;Development;Doctor's Degree;Educational workshop;Engineering;Enrollment;evidence base;experience;Faculty;faculty mentor;Florida;Historically Black Colleges and Universities;Institution;interest;Leadership;leadership development;Learning;matriculation;Mentors;Outcome;peer coaching;Positioning Attribute;Preparation;programs;recruit;Research;Research Training;Science;Self Efficacy;social;STEM research;Structure;Students;success;symposium;theories;Training;training opportunity;Training Programs;Universities;university student

PROJECT_TITLE: Bridges to the Baccalaureate at Florida A&M University

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Dissemination and Implementation Research;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety;Prevention

ORG_CITY: INDIANAPOLIS

ORG_DEPT: SURGERY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Patients with postoperative delirium are at higher risk for other surgical complications, prolonged hospital stays, cognitive decline, higher costs, and mortality. As nearly half of delirium cases can be prevented with multicomponent interventions, identifying high risk patients preoperatively may offer an opportunity to improve their perioperative cognitive health. This project will develop and test a passive method for postoperative delirium risk prediction using routine care electronic health data and artificial intelligence techniques.

PI_NAMEs: MOHANTY, SANJAY  (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: acceptability and feasibility;Active Learning;Acute;advanced analytics;Age;Aging;Alzheimer's Disease;Alzheimer's disease model;American;Artificial Intelligence;Attention;Award;brain health;Cardiopulmonary;Cardiovascular system;career;career development;clinical decision support;Clinical Sciences;Cognition;Cognitive;cognitive disability;cognitive enhancement;cognitive recovery;cohort;comorbidity;Computerized Medical Record;cost;Data;Databases;Delirium;Dementia;design;Detection;Development;Development Plans;Diagnosis;Digital biomarker;digital models;Disease;Dropout;efficacy evaluation;efficacy trial;electronic health data;electronic health information;Electronic Health Record;Enrollment;Environment;feasibility testing;frailty;functional decline;functional disability;functional status;Funding;Future;Goals;Health;Health system;Healthcare;high risk;Hospital complications;Hospitals;Impaired cognition;implementation science;improved;Indiana;Informed Consent;International;Intervention;K-Series Research Career Programs;Length of Stay;Machine Learning;machine learning algorithm;Medical Informatics;Mentors;Methods;Modeling;mortality;multi-component intervention;multidisciplinary;nutrition;older adult;older patient;Operative Surgical Procedures;Outcome;Patient Care;patient oriented;Patients;Performance;Perioperative;Physiological;Polypharmacy;postoperative delirium;Postoperative Period;predictive modeling;Preparation;prevent;Prevention;Process;prospective;Psychiatric Diagnosis;Randomized Controlled Clinical Trials;randomized, clinical trials;Randomized, Controlled Trials;Recovery of Function;Reproducibility;Research;Research Personnel;Research Project Grants;research study;Risk;Risk Factors;risk prediction;risk stratification;routine care;screening;Senior Scientist;Structure;support tools;Surgical complication;Survivors;Syndrome;System;Techniques;Testing;Text;Time;Translational Research;United States National Institutes of Health;Universities;usability

PROJECT_TITLE: Using Routine Care Electronic Medical Record Data and Artificial Intelligence to Develop a Passive Digital Marker to Predict Postoperative Delirium

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Malaria remains one of the biggest infectious disease problems in the world, and a major reason for the continued problem is resistance of malaria parasites to available drugs. Resistance appears to be increasing, in particular to components of new artemisinin-based combination regimens. The goals of this project will be to assess resistance to antimalarial drugs in Uganda, to characterize genetic features of parasites with varied drug sensitivity, and to characterize impacts of varied drug sensitivity on parasite fitness, all to offer tools to better control the spread of drug resistance.

PI_NAMEs: ROSENTHAL, PHILIP JON (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Affect;Africa;Amodiaquine;Anti-malarial drug resistance;Anti-malarials;artemether;Artemisinins;Asia;benflumetol;Chemoprevention;Clinic;Clinical;Clinical Research;Clinical Trials;Coculture Techniques;cohort;Cohort Studies;Combined Modality Therapy;Communicable Diseases;cost;Data;Development;Drug Monitoring;Drug resistance;drug sensitivity;Epidemiology;Evaluation;experimental study;Falciparum Malaria;fitness;Future;Genetic;Genetic Polymorphism;Genotype;Goals;Growth;improved;In Vitro;Individual;insight;interest;Laboratories;Laboratory Study;Link;Malaria;Malaria prevention;Measures;Mediating;Mediator;member;Molecular;Monitor;Morbidity - disease rate;mortality;Mutation;Outcome;Parasite resistance;Parasites;Parasitology;Patients;Pharmaceutical Preparations;Phenotype;Plasmodium falciparum;pressure;programs;Regimen;Resistance;resistance mechanism;Risk;Rwanda;Sampling;Site;standard care;surveillance network;Surveillance Program;Technology;Testing;Time;tool;Treatment Efficacy;Uganda

PROJECT_TITLE: Resistance of Malaria Parasites to Artemisinin-Based Combination Therapies in Uganda

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Nanotechnology;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: Boston

ORG_NAME: TUFTS UNIVERSITY MEDFORD

ORG_STATE: MA

PHR: PROJECT NARRATIVE Surgery is the current mainstay treatment for head and neck cancer and the survival rate in these patients has not changed in the past decade. To avoid positive tumor margins, excessive normal tissue is also surgically removed exacerbating the poor quality of life in these patients. There is no localized treatment that can shrink the tumors to avoid surgery or to enable minimal removal of normal tissue. To address this major need, we are developing a nanoplatform called Verosite to aid in image-guided oxygen enhanced photodynamic treatment of tumors that can drastically reduce normal tissue resection and recurrence rates leading to improvement in the overall health and patients’ quality of life.

PI_NAMEs: MALLIDI, SRIVALLEESHA  (contact)

PROGRAM_OFFICER_NAME: PEREZ, J MANUEL

PROJECT_TERMS: absorption;Acute;Address;Adjuvant;Adjuvant Chemotherapy;Adjuvant Radiotherapy;Aftercare;Appearance;Beds;Biodistribution;Biological;Biological Markers;Blood Vessels;Cancer Model;cancer therapy;Cell surface;Cetuximab;Chemoresistance;chemotherapy;Chemotherapy and/or radiation;Clinical;clinical translation;contrast imaging;Contrast Media;Cosmetics;cost;Data;Deglutition;Disease;Dose;dosimetry;Drug Kinetics;Dyes;Eating;Encapsulated;Environment;Epidermal Growth Factor Receptor;Equilibrium;Excision;FDA approved;Feedback;Fluorescence;fluorescence imaging;fluorescence-guided surgery;Fluorocarbons;Food;Gases;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;healing;Health;Histopathology;Hypoxia;image guided;Image-Guided Surgery;improved;In complete remission;in vivo;Indocyanine Green;insight;Invaded;irradiation;Kinetics;Life;Light;Liquid substance;local drug delivery;Localized Malignant Neoplasm;loss of function;Mainstreaming;malignant mouth neoplasm;Mastication;Molecular;Monitor;mouse model;nanoDroplet;nanodrug;nanotechnology platform;Necrosis;Neoadjuvant Therapy;Normal tissue morphology;Operative Surgical Procedures;Oral mucous membrane structure;Organ;Outcome;overexpression;Oxygen;Pathologic;patient population;Patient-Focused Outcomes;Patients;Penetration;Pharmaceutical Preparations;phase change;photoacoustic imaging;Photosensitizing Agents;Phototherapy;psychologic;PUVA Photochemotherapy;Quality of life;Radiation therapy;Radio;receptor expression;Recurrence;Resected;Residual Neoplasm;side effect;Site;Solid Neoplasm;spatiotemporal;Speech;success;Surface;Surgeon;Surgical margins;Survival Rate;systemic toxicity;targeted treatment;Therapeutic;Time;Tissues;tool;Toxic effect;Treatment Efficacy;Treatment outcome;treatment response;treatment strategy;tumor;Tumor Burden;tumor eradication;Tumor stage;Tumor Volume;uptake;Verteporfin

PROJECT_TITLE: Image-guided oxygen enhanced photodynamic therapy with multi-functional nanodroplets to improve head and neck cancer treatment outcomes

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Congenital birth defects of the eye and retina cause structural malformations and visual impairment that can result in complete blindness. Causative genes have been identified and knowledge of their role in eye formation is providing the foundation for stem cell and regeneration-based treatments for inherited ocular defects, retinal injury, and disease.

PI_NAMEs: LEVINE, EDWARD M (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Address;Affect;Alleles;ATAC-seq;bisulfite sequencing;Blindness;Candidate Disease Gene;Cells;Complete Blindness;Congenital Abnormality;CRISPR/Cas technology;Data;Defect;Development;Disease;disease-causing mutation;early onset;Electroporation;Embryo;Epigenetic Process;Eye;eye formation;Foundations;Gene Expression;Gene Expression Regulation;Gene Silencing;Generations;Genes;Genetic Models;Genetic Recombination;Germ Lines;Harvest;histogenesis;Homeobox;Human;Hyperpigmentation;in vivo;inducible Cre;Inherited;Injury;insight;Knock-in;Knock-out;Knowledge;LacZ Genes;LoxP-flanked allele;Microphthalmos;Mus;mutant;Mutation;Natural regeneration;neurogenesis;Organ;Organogenesis;Output;Phenotype;postmitotic;prevent;Process;Production;progenitor;programs;Proliferating;Property;Regulation;Reporter;Retina;retinal progenitor cell;Role;single-cell RNA sequencing;Specific qualifier value;stem cell proliferation;stem cells;Structural defect;Tamoxifen;Testing;Time;Tissues;transcription factor;transcriptome sequencing;Visual impairment;Visual System;whole genome

PROJECT_TITLE: Vsx2 Dependent Regulation of Retinal Progenitor  Cell Properties

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Alzheimer’s Disease is a devastating disease with enormous unmet medical need and few treatments, and it is likely necessary to understand, detect, and treat Alzheimer’s Disease earlier in disease development. Patients often exhibit aberrant neural activity very early, even before Alzheimer’s Disease pathology or cognitive decline, and aberrant neural activity may be a primary driver of and tractable therapeutic target for Alzheimer’s Disease. This project has discovered a neural stimulation approach that fully restores learning and memory function in an Alzheimer’s mouse model, and will use cutting-edge systems neuroscience techniques to conduct single-cell resolution examination and perturbation of the brain to determine the mechanistic role of aberrant neural activity in cognitive decline in Alzheimer’s Disease and how it is reversed, to help the intelligent design of new, precise, and earlier biomarkers, diagnostic strategies, and therapeutic treatments.

PI_NAMEs: HO, THEODORE TERENCE (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: 3-Dimensional;Affect;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease therapy;Amyloid beta-Protein;Anatomy;Antibodies;Brain;Brain region;career development;Cells;Clinical;clinically relevant;Cognition;Cognitive;Cognitive deficits;cognitive performance;cognitive task;Compensation;Data;design;Development;diagnostic strategy;Disease;Disease Progression;early detection biomarkers;Exhibits;experimental study;Faculty;Head;Human;human imaging;Image;imaging modality;Impaired cognition;improved;Label;Learning;Light;Link;Longitudinal Studies;Maps;Medical;Memory;Mentors;Microscopy;Modeling;mouse model;Mus;neural;neural stimulation;Neurons;Neurosciences;optogenetics;Pathology;Patients;Pattern;Phase;Play;Positioning Attribute;Preparation;prospective;protein aggregation;Protocols documentation;recruit;Research Personnel;Resolution;Role;skills;Stains;Symptoms;System;tau aggregation;tau Proteins;Techniques;Technology;temporal measurement;Testing;Therapeutic;therapeutic target;Time;Tissues;Training;two-photon;Universities;Virus;Work

PROJECT_TITLE: Identifying the mechanistic role of and reversing aberrant neural activity in Alzheimer's Disease

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Patient Safety;Prevention

ORG_CITY: MORRISTOWN

ORG_NAME: ATLANTIC HEALTH SYSTEM, INC.

ORG_STATE: NJ

PHR: Project Narrative As the first NCORP Community Site in the state, AHCC CORP serves three-quarters of the New Jersey population across a diverse range of demographics.  AHCC CORP expands the NCORP network by 6.5M people, advancing the state of the science in cancer prevention, control, screening, care delivery research, and precision medicine studies through biospecimen collection, as well as providing critical access to treatment and imaging studies conducted by the National Clinical Trials Network. With a higher cancer incidence rate than the US as a whole, New Jersey is an underrepresented area for cancer prevention and control research.

PI_NAMEs: WHITMAN, ERIC  (contact)

PROGRAM_OFFICER_NAME: WHITE, VANESSA

PROJECT_TERMS: Adult;Age;Area;base;cancer care;Cancer Control;Cancer Control Research;cancer health disparity;cancer prevention;care delivery;Catchment Area;chatbot;Childhood;Clinical;clinical implementation;Clinical Trials;clinically significant;Collaborations;Collection;Communities;Community Clinical Oncology Program;community engagement;community setting;County;Data Collection;data submission;demographics;Development;disparity reduction;Enrollment;experience;Genomics;Geography;Goals;Health;Health Services Accessibility;Healthcare Systems;imaging study;improved;Incidence;Infrastructure;innovation;inter-institutional;Language;Leadership;Malignant Childhood Neoplasm;Malignant Neoplasms;medical specialist;medical specialties;member;mentoring community;Modality;molecular targeted therapies;National Clinical Trials Network;Natural Language Processing;New Jersey;Oncologist;Oncology;organizational structure;Outcome;outcome disparities;Participant;patient population;Patient-Focused Outcomes;Patients;Pediatric Hospitals;Persons;Physicians;Population;Population Heterogeneity;precision medicine;prevention clinical trial;Procedures;Process;programs;Protocols documentation;Provider;Quality of Care;recruit;Research;Research Personnel;research study;retention rate;Science;Scientific Advances and Accomplishments;screening;Site;social media;Specimen;tumor;Underrepresented Populations

PROJECT_TITLE: The Atlantic Health Cancer Consortium Community Oncology Research Program (AHCC CORP)


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Diabetes;Digestive Diseases;Pediatric;Prevention

PHR: PROJECT NARRATIVE The Stanford Clinical Center will lead and actively recruit patients into the Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC). Collected specimens from this cohort will be studied to develop new immunological and hormonal insights into the relationship between acute pancreatitis and diabetes, in particular type 1 diabetes mellitus. These insights will inform new diagnostic tests and treatments.

PI_NAMEs: BASINA, MARINA ;PARK, WALTER GWANG-UP (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Abbreviations;acute pancreatitis;Address;Antibodies;Autoantibodies;biobank;Biological Specimen Banks;biomarker validation;chronic pancreatitis;Clinical;clinical center;clinical infrastructure;cohort;Collaborations;Cytoplasm;Development;Diabetes Mellitus;Diagnostic tests;Early Diagnosis;Endocrinology;Enteroglucagon;Etiology;Evolution;Exocrine pancreatic insufficiency;experience;Functional disorder;Future;glucagon-like peptide;Glutamate Decarboxylase;Goals;Hormonal;Hormonal Change;Human;Immune response;Immune system;Immunologic Monitoring;Immunologics;Immunology;Incidence;Infrastructure;innovation;insight;Insulin;Insulin-Dependent Diabetes Mellitus;insulinoma;Investigation;Islet Cell;Lead;Longitudinal cohort;Malignant neoplasm of pancreas;Methods;Non-Insulin-Dependent Diabetes Mellitus;novel;novel diagnostics;Pancreatic Ductal Adenocarcinoma;Pancreatitis;Patient Recruitments;Patients;Positioning Attribute;prevent;Prevention;Prognosis;prospective;Prospective cohort;Protocols documentation;recruit;Recruitment Activity;Research;Research Design;Research Infrastructure;Resources;response;risk stratification;Role;Specimen;Standardization;zinc-binding protein

PROJECT_TITLE: The Stanford Clinical Center for the Study of Type 1 Diabetes in Acute Pancreatitis


ADMINISTERING_IC: HD

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Genetics

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

PHR: PROJECT NARRATIVE Regulation of gene expression at the RNA level in the germline is crucial for directing proper germ cell function and gametogenesis while maintaining the plasticity necessary for embryonic development. This study will explore the role of ADARs, a class of RNA binding protein, in germline RNA regulation. Insights gained here will increase our understanding of germline and reproductive biology and the complex regulation required for fine-tuning the molecular processes of gametogenesis and early embryonic development.

PI_NAMEs: ERDMANN, EMILY ANN (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Address;Adenosine;Adult;Affect;Animals;Autoimmune Diseases;Binding;Biogenesis;Bioinformatics;Biology;Caenorhabditis elegans;Cell Physiology;Complex;Coupled;CRISPR/Cas technology;Data;Deaminase;Deamination;Defect;Development;differential expression;Dissection;dsRNA adenosine deaminase;Embryo;Embryonic Development;Ensure;Event;experience;experimental study;Gametogenesis;Gene Expression Regulation;Genes;Genetic Transcription;Genome;genome editing;Germ Cells;Germ Lines;Goals;high resolution imaging;High-Throughput Nucleotide Sequencing;Human Pathology;Immunoprecipitation;in vivo imaging;Inosine;insight;Investigation;Maintenance;Malignant Neoplasms;Messenger RNA;Metabolic Diseases;Methods;Molecular;Natural Immunity;Nematoda;Nerve Tissue;Nervous System;Nervous System Disorder;neural;Northern Blotting;offspring;Pathway interactions;Phenotype;Physiological;Play;Population;Process;programs;Regulation;Reproduction;Reproductive Biology;Research;Ribosomal RNA;Ribosomes;RNA;RNA Binding;RNA Editing;RNA-Binding Proteins;Role;Site;Small RNA;Stress;Surveys;Tissues;Training;Transcript;transcriptome sequencing;Translational Repression;tumorigenesis;Visualization;Work

PROJECT_TITLE: Investigating the Roles of ADARs and A-to-I RNA Editing in Germline RNA Regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


NIH_SPENDING_CATS: Diabetes;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

PHR: Retinopathies, proliferative retinopathies, and age-related macular degeneration are the leading causes of vision loss. Major factors associated with these diseases are the development of new blood vessels that are non-productive and vulnerable to hemorrhage. Therefore, understanding the mechanisms underlying the abnormal blood vessel development may identify novel target molecules that may lead to the development of selective therapeutics against these ocular diseases.

PI_NAMEs: RAO, GADIPARTHI N (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Address;Adherens Junction;adherent junction;Adult;Affect;Age related macular degeneration;angiogenesis;Animal Model;ATF6 gene;beta catenin;bevacizumab;Binding;Blindness;blood vessel development;Blood Vessels;cadherin 5;cell motility;Cell Proliferation;Cell Survival;Choroid;Complex;conditional knockout;Cyclin D1;Development;Diabetes Mellitus;diabetic patient;Diabetic Retinopathy;Disease;Drug resistance;endoplasmic reticulum stress;Endothelial Cells;Event;Eye diseases;GRP78 gene;Hemorrhage;Homologous Gene;Hypoxia;IL8 gene;Infant;inhibitor;light transmission;Link;Mediating;Modeling;Mus;neoplastic cell;neovascularization;Neural Retina;neutralizing antibody;NF-kappa B;novel;Outcome Study;Oxygen;Pathologic;Pathologic Neovascularization;Persons;pharmacologic;Play;Proliferating;proliferative diabetic retinopathy;Proteins;pup;Reporting;response;Retina;retinal angiogenesis;Retinal Diseases;Retinal Neovascularization;Retinal Vascular Occlusion;Retinopathy of Prematurity;Role;Signal Transduction;small hairpin RNA;STAT3 gene;targeted treatment;Testing;Therapeutic;therapeutic target;Time Study;transcription factor;Tube;tumor growth;Vascular Diseases;Vascular Endothelial Growth Factors;VEGFA gene;Vision;Vitreous Hemorrhage

PROJECT_TITLE: GRP78 signaling and retinal angiogenesis

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Radiation Oncology;Women's Health Research

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project Narrative Radiotherapy is important to achieve durable breast cancer control, but due to the difficulty of setting up and imaging the breast, the treatment is crude, resulting in life-changing side effects. In the proposed project, a novel soft robot will be developed and optimized to improve the individual patient breast setup. A dedicated breast CT will be synergistically developed to provide the needed image guidance for precision breast radiotherapy.

PI_NAMEs: JIN, LIHUA ;SHENG, KE  (contact)

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: Acute;Affect;Air;Algorithms;Anatomy;Biological;Biomechanics;Biomedical Engineering;Breast;Breast Cancer Patient;breast imaging;Cancer Control;Cardiac;Chest wall structure;Chronic;Climacteric;Clinical;Clinical Research;Clinical Sciences;cone-beam computed tomography;Conformal Radiotherapy;cost;curative treatments;Dedications;deep neural network;Development;Devices;disorder control;Dose;effectiveness evaluation;Engineering;experience;flexibility;Force of Gravity;Gait;Geometry;Goals;Heart;Height;Image;image guided;image guided radiation therapy;Immobilization;improved;Individual;individual patient;Infrastructure;Lead;Life;Lifting;Lung;Machine Learning;Malignant Breast Neoplasm;Mechanics;Membrane;Methods;Morphology;Motion;Nodal;novel;novel strategies;Optics;Organ;Outcome;Patient observation;patient tolerability;Patients;Performance;Physics;Play;Positioning Attribute;Posture;prevent;Prone Position;Property;prototype;Quality of life;Radiation Dose Unit;Radiation therapy;Radiology Specialty;reconstruction;Reproducibility;research and development;Research Project Grants;Resolution;respiratory;Rest;Robot;Robotics;Roentgen Rays;Secure;Shapes;side effect;skeletal;Structure;success;Supination;Supine Position;Surface;Systems Integration;Techniques;Testing;Thinness;Toxic effect;tumor;United States National Institutes of Health;Validation;volunteer;X-Ray Computed Tomography;X-Ray Therapy

PROJECT_TITLE: Precision breast radiotherapy with the soft robot and supine CT


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: RENO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: PROJECT NARRATIVE Ticks are obligate hematophagous arthropods and ecto-parasites of every class of vertebrates in almost every region of the world. Despite the increasing information available on ticks, there is lack of molecular tools to understand the basis of tick phenotypes and tick-pathogen interactions. This proposal will develop new tools for understanding tick biology.

PI_NAMEs: GULIA-NUSS, MONIKA  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Adult;Anaplasma;Arthropods;ATAC-seq;Babesia;Binding;Bioinformatics;Biological Assay;Biology;Black-legged Tick;Blood;Borrelia burgdorferi;Cell Line;Centers for Disease Control and Prevention (U.S.);Chromatin;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;CMV promoter;Complex;CRISPR/Cas technology;Development;differential expression;DNA;Embryo;Eukaryotic Cell;experience;Eye Color;feeding;functional genomics;Future;Gene Combinations;Gene Expression;gene function;Genes;genetic regulatory protein;genome editing;genome sequencing;genomic locus;genomic tools;Genomics;Goals;Heat shock proteins;High-Throughput Nucleotide Sequencing;improved;in vivo evaluation;Individual;Injections;Insecta;knockout gene;Life;Lyme Disease;Messenger RNA;Methods;Modeling;Molecular;Molecular Conformation;mutant;Mutation;Nuclear;Order Spirochaetales;Organism;pathogen;Pattern;Phenotype;promoter;Promoter Regions;Proteins;protocol development;Protocols documentation;Reporter;Research;Research Personnel;Rickettsia;Risk Taking;screening;Screening procedure;Serine Protease;sex;success;System;Technology;Temperature;Testing;Ticks;Tissues;tool;Transcript;transcriptome;transcriptome sequencing;transcriptomics;transmission process;Transposase;United States;Validation;vector;Vector-transmitted infectious disease;Vertebrates;Viral;Virus;Vitellogenins;Work

PROJECT_TITLE: Identification of stage-and tissue-specific endogenous tick promoters

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE To explore therapeutic platforms for glioblastoma (GBM), we have developed a new transgenic mouse model of T cell receptor (TCR)-directed cell therapy (“MISTIC”) against an endogenous neoantigen in GL261 to explore the efficacy of this treatment approach in established transplantable mouse models and also a novel model of EGFR-driven and neoantigen-defined spontaneous GBM. We will evaluate how to engineer MISTIC T cells to be able to remodel the GBM microenvironment and effectively treat heterogeneous GBM tumors and also explore why some tumors are able to escape adoptive cell therapy. Together, our proposed work will provide new insights into the effective use of directed and engineered TCR cell therapy in GBM that will expand our understanding of immunotherapeutic approaches in the central nervous system and also establish a foundation for immediate clinical translation.

PI_NAMEs: CHAREST, ALAIN ;DUNN, GAVIN PETER (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Address;Adoptive Cell Transfers;Adoptive Transfer;Adult;Aftercare;aggressive therapy;Anatomy;Antigen Presentation;Antigen Targeting;antigen-specific T cells;Antigens;Biological;Biological Models;Blood - brain barrier anatomy;Brain Neoplasms;brain parenchyma;cancer immunotherapy;Cell Therapy;Cells;cellular engineering;Central Nervous System;Central Nervous System Diseases;chemokine;Clinical;clinical translation;Clonal Expansion;Clustered Regularly Interspaced Short Palindromic Repeats;cytokine;Data;Dendritic Cells;design;Diagnosis;Disease;effective therapy;efficacy testing;Elements;engineered T cells;Engineering;Epidermal Growth Factor Receptor;epigenomics;Epitope spreading;Escape Mutant;FDA approved;Foundations;Functional disorder;gene therapy;genomic profiling;Genomics;Glioblastoma;Goals;Growth Factor;Heterogeneity;Immunobiology;immunogenic;immunogenicity;Immunologics;Immunotherapeutic agent;Immunotherapy;improved;Infiltration;inhibitor;insight;Location;lymph nodes;Lymphatic;Lymphocyte;Malignant neoplasm of central nervous system;Malignant Neoplasms;model development;Modeling;Molecular;mouse model;Mus;mutant;Myelogenous;Nature;neoantigens;Neoplasm Transplantation;neoplastic cell;novel;Observational Study;Oncology;Outcome;Pathway interactions;Patients;Physiological;Population;pre-clinical;Process;Resistance;Resolution;Site;System;T cell infiltration;T cell response;T cell therapy;T-Cell Receptor;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapy development;transcriptomics;Transgenic Mice;Transgenic Organisms;translational applications;Transplantation;Treatment Efficacy;tumor;Tumor Antigens;Tumor Escape;tumor heterogeneity;tumor progression;Work

PROJECT_TITLE: Engineering T Cell Adoptive Therapy for Glioblastoma

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Sleep Research

ORG_CITY: BERKELEY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative The novel treatment to be tested—the Memory Support Intervention (MSI)—is a powerful and deployable approach that has potential to substantially improve treatment outcomes for midlife and older adults across a wide range of treatments. The MSI will be tested in combination with a treatment for sleep and circadian problems which are highly prevalent among midlife and older adults.

PI_NAMEs: HARVEY, ALLISON G (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: absorption;Address;Adherence;Adult;Aftercare;Age;age group;Age Years;Aging;behavior change;circadian;Circadian Dysregulation;cognitive function;Cognitive Science;community organizations;confirmatory trial;Data;Dependence;Diagnostic;disability;Education;Elements;experience;follow-up;Health;Health Promotion;health service use;Health Services;healthy aging;Impairment;improved;improved outcome;improvement on sleep;Individual;innovation;Intervention;Learning;Length;Life;Life Expectancy;Literature;Low income;Mediating;Memory;Memory impairment;middle age;Mobility decline;Modeling;novel;older adult;Older Population;Outcome;Participant;Patient Compliance;Patients;Personal Satisfaction;Persons;poor sleep;Provider;Random Allocation;recruit;Reporting;Research;Sampling;Sleep;Sleep Disorders;Sleep disturbances;Sleeplessness;Strategic Planning;Subgroup;telehealth;Testing;treatment adherence;treatment as usual;treatment comparison;treatment effect;Treatment outcome;treatment response;United States;United States National Institutes of Health;young adult

PROJECT_TITLE: Improving sleep and circadian functioning, daytime functioning, and well-being for midlife and older adults by improving patient memory for a transdiagnostic sleep and circadian treatment

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE This project will integrate chemoproteomics, metabolomics, and mouse physiology to identify intracellular transport mechanisms for signaling metabolites. Using metabolite-like chemical probes, we will perform proteome-wide interaction studies to map dedicated protein machinery responsible for trafficking nuclear receptor ligands to the nucleus. Completing this work will shed light on the regulation of intracellular metabolite trafficking and its impact on nuclear receptors’ transcriptional activity. Additionally, completion of these studies will provide new targets for developing therapeutic agents that modulate nuclear receptor function by controlling ligand availability.

PI_NAMEs: GALMOZZI, ANDREA  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Automobile Driving;BACH1 gene;Binding;Biological Process;Biology;Cell Cycle;Cell Nucleus;Cell Physiology;Cells;Cellular Assay;Cellular biology;Chemicals;chemoproteomics;Dedications;Defect;Disease;experience;Family;Fatty Acids;Genetic Transcription;Goals;Heme;Homeostasis;Immunologics;Inflammatory;Intracellular Transport;Knowledge;Ligands;Malignant Neoplasms;Maps;Metabolic;Metabolic Diseases;Metabolism;metabolomics;Mitochondria;Molecular;Molecular Chaperones;multidisciplinary;Mus;novel;Nuclear Receptors;Nutritional;Organelles;Peroxisome Proliferator-Activated Receptors;Physiology;protein metabolite;Proteins;Proteome;receptor function;Regulation;response;Second Messenger Systems;sensor;Signal Transduction;Site;Stimulus;Technology;Therapeutic Agents;Time;tool;trafficking;transcription factor;Transcriptional Regulation;Travel;Work

PROJECT_TITLE: Dissecting intracellular metabolite trafficking using chemoproteomics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(55)R]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Pediatric;Social Determinants of Health

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: PURDUE UNIVERSITY

PHR: NARRATIVE See Us-Be Us: Inspiring Future Veterinarians Using a Veterinary STEM Ecosystem has as a long-term strategy to establish a diverse veterinary workforce by uniting veterinary colleges, veterinary work settings (practice, research, industry, government), and community entities serving disadvantaged youth in this important mission. Diverse veterinary role models and veterinary STEM educational materials will be provided to K-12 students to facilitate career exploration and experiential learning opportunities. It is anticipated that a veterinary-scientist workforce that reflects societal demographics will improve health literacy and reduce health disparities in people and their animals.

PI_NAMEs: SAN MIGUEL, SANDRA F (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Active Learning;Address;Age;Animals;Awareness;career;Career Choice;Career Exploration;Certification;Child;Clinical;college;Communication;Communities;Cultural Backgrounds;Databases;demographics;design;Disadvantaged;diversity and inclusion;Ecosystem;Education;education resources;Educational Curriculum;Educational Materials;educationally disadvantaged;elementary school;Ensure;Equity;ethnic disparity;Ethnic Origin;Exercise;experience;Exposure to;Fostering;Future;Goals;Government;Health;health literacy;High School Student;Home;impression;improved;Industry;innovation;interest;Interview;junior high school;K-12 student;Learning;Medical;Medical Research;medical schools;Medical Students;Mentors;Mentorship;Middle School Student;Mind;Mission;Modeling;network models;Next Generation Science Standards;Online Systems;Outcome;Persons;Physicians;podcast;Positioning Attribute;Preparation;Primary School Faculty;Professional Organizations;programs;Public Health;racial disparity;racial diversity;recruit;Reduce health disparities;Research;resource guides;Resources;Role;role model;Schools;Science;Science, Technology, Engineering and Mathematics Education;Scientist;skills;Societies;socioeconomic disadvantage;STEM career;STEM curriculum;student participation;Students;teacher;Technology;Time;Training;Underrepresented Students;underserved community;underserved students;United States National Institutes of Health;Veterinarians;Veterinary Medicine;virtual;Vision;Work;working group;Workplace;Youth

PROJECT_TITLE: See Us-Be Us: Inspiring future veterinarians using a Veterinary STEM Ecosystem

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]