ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative Obesity, the leading cause of global morbidity and mortality, is characterized by hypothalamic resistance to the anorexigenic hormone leptin. Since leptin therapy’s effectiveness against obesity is hindered by leptin resistance, it is crucial to understand the mechanisms behind this resistance. This study aims to elucidate how a high-fat diet induces leptin resistance through hypothalamic epigenetic modifications and explores intermittent fasting as a potential method to reverse these changes and restore leptin sensitivity.

PI_NAMEs: KIM, MIN HYUN  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Address;Adipose tissue;Adult;Anatomy;Architecture;Attention;Autophagocytosis;Biological Process;Body Weight;Body Weight decreased;Cell Line;Cells;ChIP-seq;Chromatin;Cytomegalovirus;Data;demethylation;Development;Diet;diet-induced obesity;Disease;Down-Regulation;Eating;Effectiveness;Environmental Risk Factor;Epidemic;Epigenetic Process;Family;Fasting;gain of function;Genes;Hepatic;High Fat Diet;Histones;Homeostasis;hormonal signals;Hormones;Hypothalamic structure;Immunity;Impairment;improved;Individual;Intermittent fasting;knock-down;Knockout Mice;Lentivirus;Leptin;leptin receptor;Leptin resistance;lipid metabolism;loss of function;Lysine;Mediating;Metabolic;Metabolic Diseases;Metabolic hormone;Metabolic syndrome;Methods;Microinjections;Modification;Molecular;Molecular Target;Morbidity - disease rate;mortality;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;Nuclear;nutrient deprivation;Obese Mice;Obesity;obesity development;obesogenic;overexpression;Pathway interactions;Peripheral;Population;Predisposition;Prevalence;promoter;Receptor Cell;receptor expression;Regulation;Resistance;response;Risk;Risk Factors;Role;Signal Pathway;Signal Transduction;small hairpin RNA;Testing;therapeutic target;transcriptome sequencing;United States;Variant;ventromedial hypothalamic nucleus

PROJECT_TITLE: Roles of hypothalamic JMJD3 in the regulation of leptin sensitivity and energy homeostasis

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: The PRKACA gene encodes for the catalytic subunit of protein kinase A. Genetic sequencing identified mutations in the catalytic subunit of kinase A linked to adenoma-associated Cushing’s syndrome, cardiac myxomas, fibrolamellar hepatocellular carcinomas, and intraductal oncocytic papillary neoplasms of the pancreas and bile ducts. We will identify the molecular mechanisms underlying these dysfunctional kinases, paving the way for alternative and innovative therapies.

PI_NAMEs: VEGLIA, GIANLUIGI  (contact)

PROGRAM_OFFICER_NAME: COUCH, JENNIFER A

PROJECT_TERMS: Active Sites;adenoma;Affect;Affinity;Alternative Therapies;Atlases;Automobile Driving;Benchmarking;bile duct;Binding;Binding Proteins;Biochemical;biochemical tools;Biological Assay;biophysical techniques;biophysical tools;Biophysics;Catalytic Domain;Cell division;Chimera organism;Chimeric Proteins;Collaborations;Communication;Complex;Coupled;Cryoelectron Microscopy;Cushing Syndrome;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;design;Disease;disease phenotype;Disease Progression;Dissociation;Distal;Endocardial Myxoma;Endocrine System Diseases;Entropy;Enzymes;Etiology;Fibrolamellar Hepatocellular Carcinoma;Fluorescence Resonance Energy Transfer;Future;Genes;Genetic;Genomic approach;Germ-Line Mutation;Heart Contractilities;Holoenzymes;Hot Spot;Image;in vivo;inhibitor;Innovative Therapy;Island;Kinetics;Lead;Length;Link;Liquid substance;Literature;macromolecular assembly;Maps;Metabolism;Methodology;Molecular;Molecular Conformation;molecular dynamics;mutant;Mutate;Mutation;Myxoma;Nature;Nucleotides;Oncogenic;Oxyphil Cells;Pancreatic duct;Papillary Neoplasm;Pathogenicity;Pathologic;Patients;Phosphorylation;Phosphotransferases;Positioning Attribute;PRKACA gene;Process;Productivity;Protein Isoforms;Regulation;Resolution;Roentgen Rays;Role;Signal Transduction;Site;Somatic Mutation;spatiotemporal;Specificity;Structure;Substrate Specificity;Techniques;Testing;trait;Translating;tumorigenesis;Variant

PROJECT_TITLE: Structural and dynamic basis for PRKACA-dependent signalopathies

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Infections due to antimicrobial resistant organisms (ARO) have long been a concern in the acute healthcare setting, but community rates have increased exponentially over the past decade. However little is understood about the prevalence and risk factors associated with community-associated ARO (CA-ARO) colonization and infection. The study goals are to: 1) characterize clinical risk factors associated with CA-ARO infections; 2) determine the prevalence and clinical risk factors associated with CA-ARO colonization in patients admitted to the acute care hospital setting; and 3) determine the prevalence and characteristics associated with CA-ARO colonization in asymptomatic community volunteers and their home environment to identify risk factors and reservoirs of CA-ARO colonization. Results of this study will directly impact clinical practice and improve patient health by providing key data to guide the use of infection prevention interventions for people at-risk for CA-ARO colonization or infection, environmental hygiene recommendations, and empiric antimicrobials.

PI_NAMEs: KWON, JENNIE H (contact)

PROGRAM_OFFICER_NAME: LIN, LEYI

PROJECT_TITLE: Combatting Community-Associated Antimicrobial Resistant Organisms Combat CA-ARO Study

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Narrative The glucagon-like peptide-1 receptor (GLP-1R) is a promising new therapeutic target for the treatment of asthma; however, the mechanisms of action of GLP-1R agonists in asthma remain unknown. This proposal will determine the direct actions of GLP-1R signaling on immune cells in asthma with or without associated obesity. This is critically important for optimizing the use of GLP-1R agonists in asthma.

PI_NAMEs: CAHILL, KATHERINE N (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Agonist;airway inflammation;Allergens;Anti-Inflammatory Agents;Asthma;asthma exacerbation;asthmatic patient;Attenuated;Biological Markers;Blood Platelets;cardiovascular risk factor;CD4 Positive T Lymphocytes;Cell Communication;Cell Physiology;Cells;cellular targeting;chemokine;Clinical;Clinical Data;Clinical Research;cohort;comorbidity;cytokine;Data;Diabetes Mellitus;diabetes risk;Disease;Exhalation;Exposure to;FDA approved;Flow Cytometry;Frequencies;Funding;Genetic;GLP-I receptor;glucagon-like peptide 1;Helper-Inducer T-Lymphocyte;HMGB1 gene;Human;IL17 gene;Immune;Immune Targeting;Immunoassay;Immunologics;improved;In Vitro;in vivo;Individual;Inflammation;Inflammation Mediators;Inflammatory;innovation;Interleukin-1 beta;Interleukin-13;Interleukin-4;Interleukin-5;Intervention Studies;Laboratories;Leukocytes;lipid mediator;Measures;Mediating;Mediator;Metabolic;Metabolic Diseases;Mus;new therapeutic target;Nitric Oxide;Non-Insulin-Dependent Diabetes Mellitus;novel;Obese Mice;obese patients;obese person;Obesity;obesity risk;obesity-associated asthma;Outcome;Pathogenesis;Pathway interactions;Patients;Pattern;periostin;peripheral blood;pharmacologic;Phase;Phenotype;Placebos;Platelet Activation;Platelet aggregation;Platelet Count measurement;Population;precision medicine;preclinical study;Production;Proliferating;Publishing;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Randomized, Controlled Trials;RANTES;receptor;receptor expression;receptor function;Receptor Signaling;Refractory Disease;Research;Research Personnel;response;response biomarker;Risk;Risk Reduction;Role;sample collection;Sampling;Serum;Signal Transduction;small molecule;Steroids;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Thinness;tool;treatment strategy;Variant;Viral

PROJECT_TITLE: GLP-1R agonist immune targets in lean and obesity-associated asthma

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke;Telehealth

ORG_CITY: COLUMBIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: Project Narrative  Stroke rehabilitation is primarily focused on reduction of stroke-related impairments, e.g., motor impairment, with the intention that impairment reduction will lead to improved ability to participate in everyday life activities, e.g., self-care, work. Despite substantial research to investigate the use of these impairment- reduction approaches in stroke, there is limited evidence to support that these approaches result in any meaningful impairment reduction that translates to improved ability to perform everyday life activities. This proposal seeks to evaluate if a stroke-rehabilitation self-management program, that targets management of chronic stroke symptoms rather than impairment reduction, can improve self-efficacy, activity performance, and quality of life in individuals with sub-acute stroke.

PI_NAMEs: BOONE, ANNA  (contact);LEE, DANBI

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Activities of Daily Living;Address;Age;Analysis of Covariance;Behavior;Blood Pressure;cardiovascular risk factor;care systems;Chi-Square Tests;Chronic;Chronic Disease;chronic stroke;Clinical;Cognitive;Communities;community engagement;Confidence Intervals;Data;Development;Education;efficacy evaluation;efficacy outcomes;Eligibility Determination;Ensure;Equilibrium;evidence base;experience;Feasibility Studies;follow-up;Friends;Goals;grandchild;Health;Healthy Eating;healthy lifestyle;Home;Hospitals;Impaired cognition;Impairment;Improve Access;improved;Individual;innovation;Intention;Intervention;Knowledge;Learning;Life;Limb structure;Literature;Measurement;Measures;Medical center;Modeling;motor impairment;multimodality;Nervous System Physiology;Neurologic Symptoms;Outcome;Participant;Patient Self-Report;Pattern;Performance;persistent symptom;Phase;Physical activity;Play;Population;post intervention;post stroke;Procedures;Process;programs;psychosocial;Quality of life;Randomized;Randomized, Controlled Trials;recruit;rehabilitation management;rehabilitation research;rehabilitation service;Rehabilitation therapy;Reporting;Research;Research Priority;restoration;Role;Sampling;Self Care;Self Efficacy;Self Management;self-management program;Severities;Single-Blind Study;Site;skills;Stroke;stroke patient;stroke recovery;stroke rehabilitation;stroke survivor;stroke symptom;symptom management;Symptoms;telehealth;Testing;Time;Translating;Treatment Efficacy;Treatment outcome;United States;Videoconferencing;virtual;Work

PROJECT_TITLE: Efficacy of the Improving Participation after Stroke Self-Management-Rehabilitation (IPASS-R) program in sub-acute stroke

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE Aneurysms are dilations of blood vessels caused by weakening and progressive enlargement of the vessel wall which increases the risk of rupture and fatal hemorrhage. There is currently no directed medical therapy to treat aneurysms, emphasizing the need to better understand their pathogenesis in an effort to devise targeted therapeutic strategies. Using mouse models with cell- specific deletion of the enzyme lysyl oxidase, known to be a cause of aortic aneurysms in humans, the overall goal of this proposal is to understand how loss of lysyl oxidase changes the arterial wall and vascular cell behavior leading to aneurysmal disease.

PI_NAMEs: HALABI, CARMEN M. (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Abdomen;Address;Affect;Age;Alleles;amine oxidase;Aneurysm;angiogenesis;Angiotensin II;Anti-Hypertensive Agents;Aortic Aneurysm;aortic arch;Aortic Diseases;Arteries;ascending aorta;blood pressure reduction;Blood Vessels;Breeding;Cardiac;Cause of Death;cell behavior;Cell Physiology;Cell Proliferation;cell type;Cells;Chest;Collagen;Cre driver;crosslink;Data;Deposition;Development;Diameter;Diaphragmatic Hernia;Disease;disease-causing mutation;Dissection;Elastic Fiber;Elastin;Endothelial Cells;endothelial dysfunction;Endothelium;Enterobacteria phage P1 Cre recombinase;Environmental Risk Factor;Enzymes;Exhibits;Extracellular Matrix;Extracellular Matrix Proteins;falls;Functional disorder;functional group;Gene Mutation;Genes;Genetic;genetic approach;Genetic Predisposition to Disease;Goals;Heart;hemodynamics;Hemorrhage;Heterozygote;Human;Hypertension;Impairment;Individual;Inherited;Investigation;loss of function mutation;Maintenance;Mediating;Medical;Modeling;mouse model;Mus;Mutation;Neural Crest;Obesity;Operative Surgical Procedures;Pathogenesis;Pathway interactions;Perinatal;Pharmaceutical Preparations;pharmacologic;Phenotype;Play;Proliferation Marker;Protein-Lysine 6-Oxidase;Proteoglycan;Pulmonary Emphysema;repaired;Risk;Role;Rupture;Ruptured Aneurysm;Signal Transduction;Smoking;Smooth Muscle Myocytes;Structure;targeted treatment;Thoracic aorta;Thoracic Aortic Aneurysm;Time;transcriptomics;Transforming Growth Factor beta;Transforming Growth Factor Beta 2;Transgenic Mice;vascular bed

PROJECT_TITLE: Cell-specific contributions of lysyl oxidase to arterial integrity

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: SEATTLE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Many variants of human proteins have been identified by sequencing, but the effects of the amino acid changes are often unknown. Annotation of these effects would be significantly aided by the results of biochemical activity assays for all the single amino acid variants of a given protein. We propose to develop a method that covalently links a unique RNA barcode to each variant, thereby allowing pooled activity assays, with the variants identified simply by sequencing of their barcodes.

PI_NAMEs: FIELDS, STANLEY  (contact);QUEITSCH, CHRISTINE

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Aliquot;Amino Acids;Bar Codes;Binding;Biochemical;Biochemistry;Biological Assay;biological research;Catalysis;Cell Culture Techniques;cell growth;Cells;Chimeric Proteins;clinically relevant;Code;Couples;Coupling;Cultured Cells;Defect;Dihydrofolate Reductase;Directed Molecular Evolution;DNA;DNA Sequence;DNA sequencing;Environment;Enzymes;Escherichia coli;experimental study;Fluorescence;Genetic Transcription;genome sequencing;Genomic approach;Genomics;Goals;Human;human genome sequencing;In Vitro;in vivo;insight;interest;Kinetics;Knowledge;Ligands;Link;Mammalian Cell;Measures;Medical Research;melting;Messenger RNA;method development;Methods;Methylation;Molecular Chaperones;mutant;Mutation;mutation screening;novel;Organism;Pathogenicity;Post-Translational Protein Processing;Property;Protein Biosynthesis;protein function;Proteins;Proteome;Proteomics;Puromycin;Recombinant Proteins;RNA;RNA Sequences;stem;Technology;Temperature;thermostability;thiopurine methyltransferase;Time;Transfer RNA;Transferase;Translations;Uracil;Variant;variant of unknown significance;Work

PROJECT_TITLE: High-throughput biochemistry with RNA-barcoded proteins

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-L (02)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative Disease-associated variation in the ABCA4 gene is the most prevalent cause of Mendelian retinal disease with extensive clinical heterogeneity including >40 clinical phenotypes, which reflect its equally vast genotypic profile with >2300 known disease-associated variants, together comprising ABCA4-associated retinopathy, ABCA4-RD, which is well-characterized in European population, but almost practically unknown for underserved minorities, especially for patients of African American (AA) descent. The proposed research program, based on large, comprehensively characterized cohort of AA patients with ABCA4-RD from 5 urban centers, is using integrated approaches of genetic analyses, quantified clinical data and functional analyses to determine the pathogenic variation in the ABCA4 locus and in the genome thereby generating a prediction matrix for ABCA4-RD for AA patients. The outcome of these studies will substantially improve diagnostic accuracy, prognostic counseling and will provide a platform for designing precise phenotype-specific treatment in clinical trials for ABCA4-RD in AA population.

PI_NAMEs: ALLIKMETS, RANDO L (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Address;Admixture;Affect;African American;African American population;Age;Alleles;Clinical;Clinical Data;clinical heterogeneity;clinical phenotype;clinical prognosis;Clinical Trials;Code;cohort;cone-rod dystrophy;Counseling;Coupled;Data;Dedications;design;diagnostic accuracy;Disease;disease diagnosis;disorder subtype;European;exome;Family;Future;Genes;Genetic;genetic analysis;genetic approach;Genetic Screening;Genetic Variation;Genome;Genotype;improved;in vitro Assay;induced pluripotent stem cell;insight;Link;Minority;molecular modeling;mouse model;Onset of illness;Organoids;Outcome Study;Pathogenicity;Patient Care;Patient Recruitments;Patients;Persons;Phenocopy;Phenotype;Population;prognostic;programs;protein expression;protein function;racial population;recruit;Research;Retina;Retinal Diseases;Retinitis Pigmentosa;segregation;Severities;Stargardt's disease;Statistical Data Interpretation;Structural Models;Structure;Testing;translational study;underserved minority;United States;Untranslated RNA;Variant

PROJECT_TITLE: Stargardt/ABCA4 disease in African Americans

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Complementary and Integrative Health;Dietary Supplements;Infectious Diseases;Microbiome;Nutrition;Prevention;Urologic Diseases

PHR: NARRATIVE Catheter-associated urinary tract infections (CAUTI) account for 40% of nosocomial infections globally, amounting to more than 1 million cases in the US alone, and costing nearly $2 billion annually. Current approaches to modify urinary catheters and materials to reduce microbial contamination have several drawbacks that limit their efficacy, and new catheter modifications that capitalize on the strengths of each approach are needed. In this project we will use 3D-printing to develop and test new 3D-bioprinted probiotic catheter devices that combine the strengths of “bacterial interference” at the catheter interface with the release of biocidal agents into the bladder and catheter lumen to preclude or disrupt CAUTI pathogenesis, while advancing our understanding of probiotic interactions with the host and uropathogenic bacteria.

PI_NAMEs: FRIEBOES, HERMANN ;GILBERT, NICOLE MARIE (contact)

PROGRAM_OFFICER_NAME: KIRKALI, ZIYA

PROJECT_TERMS: 3-Dimensional;3D Print;Adhesions;Adult;Affect;Anatomy;Antibiotic Resistance;Antibiotics;antimicrobial;Architecture;Bacteria;Bacterial Attachment Site;Bacterial Counts;Bacterial Interference;Biocide;biofilm species;bioprinting;Bladder;Bladder Tissue;catheter associated UTI;Catheters;Cell Line;Cells;chemokine;Clinical;cost;cytokine;Data;Deposition;design;Development;Devices;Disease Marker;Disease Progression;Dryness;Electrostatics;fabrication;Fibrinogen;Formulation;Foundations;Future;Generations;Health Promotion;Histology;Human;Hydrogen Peroxide;Immune response;Implant;improved outcome;In Vitro;in vivo;Indwelling Catheter;Infection;Infection prevention;Infective cystitis;Inflammatory Response;Infusion procedures;insight;Lactic acid;Lactobacillus;Lactobacillus casei rhamnosus;Life;Measures;Mechanics;Medical Device;microbial;Microbial Biofilms;Modeling;Modification;mouse model;Mucous Membrane;multidisciplinary;Mus;Nosocomial Infections;novel;Outcomes Research;pathogen;Pathogenesis;Pathogenicity;Patients;Physiological;pre-clinical;Pre-Clinical Model;prevent;Prevention;probiotic therapy;Probiotics;prototype;Risk Reduction;Safety;scaffold;Sepsis;Silicones;Source;Specific qualifier value;Surface;Technology;Testing;Therapeutic;Tissue Model;Tissues;Translations;Tube;urinary;Urinary Catheterization;Urinary tract;Urine;Uropathogen;Uropathogenic E. coli;Urothelial Cell;Urothelium;Work

PROJECT_TITLE: 3D-bioprinting of probiotic bacterial interference catheters for prevention of catheter-associated urinary tract infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-W (05)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: The proposed research is relevant to public health because it aims to develop a new suite of MRI tools (including leading-edge hardware and software) that can be synergistically combined with the unique ultrahigh field of 10.5 Tesla and high-performance head gradients to enable rapid acquisition of high-quality functional MRI at unprecedented spatiotemporal resolutions, thereby increasing our ability to study human brain function in health and disease at the mesoscopic scale. Once such a suite of MRI tools has been developed, there will be a potential for opening new research horizons, particularly in RF coil design, parallel transmission, data acquisition, image reconstruction, functional brain mapping, and their application to study the human brain. Thus, the proposed research is relevant to the NIBIB’s mission, which is to improve health by leading the development and accelerating the application of biomedical technologies.

PI_NAMEs: VIZIOLI, LUCA ;WU, XIAOPING  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: 3-Dimensional;Acceleration;Applications Grants;arterial spin labeling;Behavior;Biomedical Technology;blood flow measurement;Brain;Brain imaging;BRAIN initiative;Brain Mapping;Brain scan;Complex;Computer software;computerized tools;connectome;Data;data acquisition;design;Detection;Development;Diffusion Magnetic Resonance Imaging;Disease;Echo-Planar Imaging;Electrophysiology (science);Elements;Fatty acid glycerol esters;Functional Magnetic Resonance Imaging;Goals;Head;Health;Healthcare;Human;Image;image reconstruction;imaging modality;Imaging Techniques;improved;innovation;instrumentation;Joints;life span;magnetic field;Magnetic Resonance;Magnetic Resonance Imaging;Maps;Measurement;Measures;meter;Methodology;Methods;millimeter;Mission;Modeling;Monitor;Morphologic artifacts;Motion;National Institute of Biomedical Imaging and Bioengineering;neuroimaging;Neurons;neuropsychiatric disorder;Neurosciences;next generation;Noise;novel;optical imaging;Performance;Physiologic pulse;prospective;Public Health;Research;Resolution;response;Rest;RF coil;saturated fat;Signal Transduction;Slice;spatiotemporal;Stimulus;Strategic Planning;synergism;Technology;temporal measurement;Time;tool;transmission process;ultra high resolution;Water;working group

PROJECT_TITLE: Ultrahigh-resolution Functional MRI of the Human Brain at 10.5 Tesla

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: LA JOLLA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative Synthetic biology has the potential to revolutionize the advancement of diagnostic and treatment approaches across a wide range of diseases. This project aims to engineer synthetic gene clocks that can slow cell aging. Key insights from this project will establish a general strategy for promoting longevity applicable to various organisms, setting the stage for clinical applications toward age-related human diseases.

PI_NAMEs: HAO, NAN  (contact);HASTY, JEFF M

PROGRAM_OFFICER_NAME: TSAP, LEONID V

PROJECT_TERMS: 5'-AMP-activated protein kinase;Address;Adverse effects;Age;age-related disease;Aging;aging mechanism;aging process;Biological;Biological Process;cell age;Cell Aging;Cell Physiology;cell type;Cells;cellular engineering;cellular longevity;Chemicals;Chromatin;clinical application;Complex;Computer Models;Coupling;Deacetylase;design;Deterioration;Diagnostic;Disease;Energy Intake;Engineering;Equilibrium;extend lifespan;Feedback;gene network;Genes;Genetic Engineering;Genetic Transcription;hallmarks of aging;Heme;Homeostasis;inducible gene expression;insight;Lead;Life;life span;Longevity;Lysine;Malignant Neoplasms;Mammals;Metabolic;metabolic rate;Microfluidics;Microscopy;Mitochondria;Mitotic;Modeling;models and simulation;Molecular;multicatalytic endopeptidase complex;network architecture;Neurodegenerative Disorders;normal aging;novel;Organism;overexpression;Pattern;Phenotype;prevent;Prevention;Process;Production;Property;protein aggregation;Proteins;Proteome;proteostasis;proteostasis loss;Research;Route;Saccharomyces cerevisiae;Saccharomycetales;sensor;stem cells;success;synthetic biology;Synthetic Genes;System;Technology;Testing;Time;trait;Transcription Coactivator;Work;Workplace;Yeasts

PROJECT_TITLE: Engineered genetic clocks for control of cellular aging

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Lung;Pulmonary Fibrosis;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Narrative Idiopathic pulmonary fibrosis (IPF) is a fatal form of interstitial lung disease and there is no effective therapeutics for the disease currently. In this proposal, we will test the hypothesis that the dysregulated signaling pathways in the pathogenically accumulating basal-like cells in IPF promote fibrogenesis by activation of the WNT signaling in the fibrotic niche, leading to impairment of AT2 renewal and fibroblast activation. This study will further aid us to understand the biology and pathology of basal cell-mediated fibrogenesis in IPF and help us to develop therapeutic strategies for patients with IPF.

PI_NAMEs: JIANG, DIANHUA  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Ablation;Alveolar;alveolar epithelium;American;Animal Model;Basal Cell;Binding;Binding Proteins;Biology;Bleomycin;cell type;Cells;Cessation of life;Chronic;Cicatrix;Complex;Data;Diagnosis;differentiation in vitro;Disease;Epithelial Cells;epithelial injury;epithelial repair;epithelial stem cell;Fibroblasts;fibrogenesis;Fibrosis;Gene Modified;Homeostasis;Human;idiopathic pulmonary fibrosis;Impairment;improved;In Vitro;in vivo;in vivo Model;Interstitial Lung Diseases;Ligands;Lung Diseases;lung injury;Lung Transplantation;Malignant Breast Neoplasm;Mediating;Mediator;Modeling;mouse model;Mus;neutralizing antibody;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Play;Population;prevent;Production;progenitor;Publications;Publishing;Pulmonary Fibrosis;receptor;Reporting;Role;Sampling;self-renewal;Signal Pathway;Signal Transduction;Site;stem cell division;stem cells;Technology;Testing;Therapeutic;therapeutically effective;Time;WNT Signaling Pathway;WNT7A gene

PROJECT_TITLE: Targeting WNT7A Signaling in Pulmonary Fibrosis

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The spatial organization of DNA and RNA in our cells regulate important genomic functions such as gene expression and localized protein production in specific sub-cellular regions, and the spatial organization of DNA and RNA is regulated in turn by upstream regulatory mechanisms. Yet our understanding of what regulators control the spatial organization of DNA and RNA is far from complete, due to a lack of large-scale discovery technologies. This study will invent a new technology platform that will enable highly efficient discovery of upstream regulators of the DNA and RNA organization, which will help elucidate and engineer the spatial axis of molecular biology in health and disease.

PI_NAMEs: WANG, SIYUAN  (contact)

PROJECT_TERMS: 3-Dimensional;Aging;Architecture;Bar Codes;Biological;Cell Nucleus;Cell Physiology;Cells;Chromatin;Chromosome Mapping;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR screen;Detection;Development;Disease;DNA;Engineering;Focal Adhesions;Gene Expression;Genetic;genetic information;Genetic Screening;Genome;Genomics;Goals;Health;high throughput screening;Human;Image;In Situ;innovation;insight;invention;Length;Link;Location;Maps;Measures;Medical;Methods;Modality;Molecular;Molecular Biology;multimodality;multiple omics;new technology;next generation;novel;Nuclear;Nuclear Lamina;Optics;Pattern;Phenotype;Production;Proteins;Reading;Regulatory Pathway;Research;RNA;RNA Transport;screening;Spatial Distribution;Techniques;Technology;technology platform;tool;transcriptome;transcriptomic profiling;virtual;Work

PROJECT_TITLE: Developing next-generation high-content image-based genetic screens for multi-omic spatial phenotypes

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ORG_CITY: LITTLE ROCK

ORG_NAME: ARKANSAS CHILDREN'S HOSPITAL RES INST

ORG_STATE: AR

PHR: PROJECT NARRATIVE Lymphatic malformations are congenital lesions of the lymphatic system that obstruct the airway, prevent oral feeding, interfere with visual development, and cause extreme pain and disfigurement. Efforts to cure LM patients with surgery, sclerotherapy, laser treatments, and immunosuppressive chemotherapy have been unsuccessful. This project utilizes a comparative multi-omics approach to develop microRNA-based therapeutics that target novel molecular pathways driving proliferation, infection, and local tissue invasion in lymphatic malformations.

PI_NAMEs: STRUB, GRAHAM M (contact)

PROJECT_TERMS: Ablation;Adhesions;Adjuvant;Affect;airway obstruction;ANGPT2 gene;Antibiotics;Automobile Driving;Binding;Blood Vessels;Caring;CD44 gene;cell behavior;Cell Line;Cell Proliferation;Cell Surface Receptors;cell type;Cells;chemotherapy;Child;Cicatrix;comparative;comparison control;Congenital Abnormality;Conjugated Carrier;Dangerousness;Data;Development;Disease;Disease Progression;disorder control;Distant;Endothelial Cells;Endothelium;Enzymes;Excision;experience;Extracellular Matrix;feeding;FRAP1 gene;Functional disorder;Gene Expression;Genes;Growth;Healthcare;Immune;improved;In Vitro;in vivo;individualized medicine;Infection;Inflammation;inhibitor;Injections;Intensive Care Units;Intercellular adhesion molecule 1;Intervention;intervention cost;Invaded;Laboratories;Lasers;Lesion;Life;Lymphatic Diseases;Lymphatic Endothelium;lymphatic malformations;Lymphatic System;lymphatic vessel;Macrophage Activation;Mass Spectrum Analysis;Measures;Mediating;Messenger RNA;MicroRNAs;Microscopic;miRNA expression profiling;Molecular;monocyte;mTOR inhibition;mTOR Inhibitor;multiple omics;Mus;Mutation;nanocarrier;Neck;Neck Mass;new growth;new therapeutic target;next generation;novel;novel strategies;Nucleotides;Oncogenes;Oncogenic;Operating Rooms;Operative Surgical Procedures;Oral;Pain;paracrine;Paracrine Communication;Pathologic;Pathway interactions;Patient Selection;Patients;Pharmaceutical Preparations;Phenotype;PIK3CA gene;PIK3CG gene;prevent;Procedures;Proliferating;protein expression;Proteins;Proteomics;Publications;Quality of life;receptor binding;Recurrence;recurrent infection;Residual state;Resources;response;restoration;Reverse Transcriptase Polymerase Chain Reaction;Sampling;Sclerosing Agents;Sclerotherapy;Serine Protease;sex;side effect;Single Nucleotide Polymorphism;Skin;Steroids;System;Testing;Therapeutic;therapeutic miRNA;therapy resistant;Tissues;Topical application;transcriptome sequencing;Translations;Treatment Failure;Tumor Suppressor Proteins;Up-Regulation;Variant;vision development;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Next Generation Treatments for Lymphatic Malformations

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anorexia;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Eating Disorders;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences;Nutrition;Pediatric;Precision Medicine;Serious Mental Illness;Suicide

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: NARRATIVE Our proposed international ENIGMA Eating Disorders Initiative will compile, harmonize, and analyze a worldwide dataset of unprecedented scale, with the power and depth to identify robust prognostic markers and markers of recovery or relapse in anorexia nervosa – a crucial but under-studied psychiatric condition, with highly elevated suicide risk. This new international initiative is a coordinated data analysis platform to determine multimodal neuroimaging signatures of AN from 31 diverse datasets worldwide (including ~1,600 individuals with AN), to assist prognosis, and discover factors that influence relapse, suicidality, and recovery.

PI_NAMEs: EHRLICH, STEFAN ;THOMPSON, PAUL M (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: 16p11.2;1q21;Acute;Address;Adolescence;Adolescent;Affect;analytical method;Anatomy;Anisotropy;Anorexia;Anorexia Nervosa;Area;autoencoder;Automobile Driving;avoidant restrictive food intake disorder;Biological Markers;Body Image;Body mass index;Body Weight;Brain;brain abnormalities;brain circuitry;Brain imaging;brain magnetic resonance imaging;Brain region;Cessation of life;Chronic Disease;Clinical;Clinical Data;Clinical Markers;cognitive development;cohort;Corpus Callosum;Data;Data Analyses;Data Set;Death Rate;Diagnosis;diffusion weighted;Disease;Disease remission;diverse data;Eating;Eating Disorders;Epidemiology;Exhibits;experience;Feeling suicidal;follow-up;food consumption;food restriction;Functional Magnetic Resonance Imaging;Future;General Population;Genetic Carriers;genetic variant;Goals;gray matter;Heart;imaging modality;Individual;International;Kidney Failure;Knowledge;life span;Longterm Follow-up;machine learning framework;machine learning method;Magnetic Resonance Imaging;Malnutrition;Maps;Measures;Medical;men;Mental disorders;Methods;Mission;Modeling;Monitor;multimodal fusion;multimodal neuroimaging;multimodality;National Institute of Mental Health;neurobiological mechanism;neuroimaging;novel;Outcome;Parietal Lobe;patient subsets;Patients;Persons;precision medicine;Prevalence;Prognosis;Prognostic Marker;Psychiatry;Publishing;Recovery;Relapse;relapse risk;Reproducibility;Research;Rest;Risk;Risk Factors;Risk Marker;risk prediction;Sampling;Severities;Site;Standardization;Starvation;Structure;Subgroup;suicidal;suicidal morbidity;suicidal risk;suicide rate;Surface;Thick;Time;Training;Treatment outcome;Underweight;Variant;Weight;weight restoration;white matter;Woman;working group

PROJECT_TITLE: The ENIGMA - Eating Disorders Initiative: A Global Neuroimaging Study of Anorexia and Factors Affecting Clinical Outcomes

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO

ORG_STATE: NM

PHR: Narrative: Proper brain function depends on the precise number and type of neurons formed during development, with disturbances in genetic programs leading to severe neurological disorders. Our proposal uses Drosophila neural stem cells that are similar to human outer radial glia to unravel the mechanisms regulating neural diversity while training diverse next-generation neuroscientists. Given the high conservation of neural stem cells, genes, and behaviors we study, our work will provide novel insights into human brain development and disorders and advance our ability to harness stem cells to replace cells lost to injury or disease.

PI_NAMEs: SYED, MUBARAK HUSSAIN  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Address;Adopted;autism spectrum disorder;Awareness;Behavior;Behavior Control;Behavioral;behavioral impairment;behavioral phenotyping;behavioral study;Bilateral;Birth;Brain;Brain region;broadening participation research;career;cell type;Cells;cohort;Columnar Cell;combinatorial;Communities;Complex;Conserved Sequence;Cues;Data;Date of birth;Defect;design;Development;disadvantaged background;Disease;diversity and inclusion;Drosophila genus;Educational workshop;Electrophysiology (science);Elements;Environmental Wind;Evolution;Faculty;fly;Food;Fostering;gene conservation;Genes;Genetic;Geography;Goals;High School Student;Homologous Gene;Human;human disease;Image;Impairment;improved;Injury;Insecta;insight;Investigation;knock-down;Label;Learning;Link;Measures;Mediating;Mental disorders;Mentors;Mexico;Microcephaly;Minority-Serving Institution;Mission;Modeling;Molecular;Morphology;National Institute of Neurological Disorders and Stroke;neglect;nerve stem cell;Nervous System Disorder;neural;neural circuit;Neurobiology;neurodevelopment;Neuroglia;neuromechanism;Neurons;Neurosciences;New Mexico;next generation;novel;Odors;Olfactory dysfunction;Output;outreach;overexpression;Pattern;Peptides;Phenotype;Population;postmitotic;programs;Property;Publishing;Pueblo Race;Race;Radial;Research;Resources;response;RNA Interference;RNA-Binding Proteins;Role;Schizophrenia;Science;science education;Sensory;Series;Shapes;Specific qualifier value;stem cells;Structure;Students;subventricular zone;symposium;System;Time;tool;Training;transcription factor;undergraduate student;Universities;Variant;way finding;Work

PROJECT_TITLE: Unraveling Neural Diversity: Decoding the Cellular and Molecular Mechanisms of Neural Circuit Formation and Function in the Drosophila Central Complex

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-G (56)]


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Urologic Diseases

ORG_DEPT: UROLOGY

PHR: PROJECT NARRATIVE This study has the potential to answer important clinical and patient-centered questions regarding the management of recurrent high-grade NMIBC, specifically identifying which patients would benefit most from radical cystectomy versus continued BST. This could reduce the public health burden of NMIBC by guiding treatment decisions and improving patient outcomes.

PI_NAMEs: GORE, JOHN L. (contact);WRIGHT, JONATHAN L.

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: Address;Age;anti-cancer research;Artificial Intelligence;Bladder;cancer care;cancer epidemiology;Cancer Patient;cancer recurrence;cancer risk;cancer type;Caregivers;Caring;Clinic;Clinical;clinical center;cohort;comparative effectiveness;Complex;Cystectomy;Decision Making;deep learning;Diagnosis;Eligibility Determination;Enrollment;Ensure;Event;Excision;Financial Hardship;financial toxicity;follow-up;Foundations;Funding;genomic biomarker;Heterogeneity;Histopathology;Household;Image;improved;intravesical;Knowledge;Life;male;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Methods;Micrometastasis;Modeling;Molecular;Molecular Machines;molecular subtypes;Morbidity - disease rate;mortality;Muscle;non-muscle invasive bladder cancer;Operative Surgical Procedures;Outcome;patient oriented;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Persons;primary outcome;progression risk;Progression-Free Survivals;Public Health;Quality of life;Radical Cystectomy;Recurrence;Regrets;Reporting;Research;Research Infrastructure;Resources;risk prediction model;risk stratification;Role;secondary outcome;Site;Staging;Treatment Cost;Treatment outcome;treatment response;trend;tumor progression;Urology

PROJECT_TITLE: BEST CARE for Recurrent NMIBC: BladdEr-Sparing Therapy and Cystectomy As TREatments

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (90)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: PORTLAND

ORG_NAME: OCHIN, INC.

ORG_STATE: OR

PHR: PROJECT NARRATIVE Access to contraceptive services for low-income women is central to reducing inequities in unintended pregnancy, a key health marker. Telemedicine (TM) has the potential to expand access to care, but widespread use of TM for contraceptive care was limited prior to the COVID19 pandemic. Our study uses health record data from Community Health Centers (2019-2025) that serve low-income women to examine inequities in the use of TM, identify unintended consequences, and explore patient preferences for TM versus face-to-face visits for contraceptive services.

PI_NAMEs: DARNEY, BLAIR GRANT (contact)

PROGRAM_OFFICER_NAME: OLADEINDE, YEWANDE A

PROJECT_TERMS: abortion;access disparities;Address;Adolescent;Adoption;Age;analytical method;Birth;black women;care fragmentation;care seeking;Caring;Characteristics;Clinic;Clinic Visits;Clinical Data;Communities;Community Health;Community Health Networks;Community Health Systems;Computers;contextual factors;Contraceptive Agents;Contraceptive methods;Counseling;COVID-19 pandemic;Data;Disparity;Economic Conditions;Electronic Health Record;Equity;Exclusion;experience;Family Planning;Federally Qualified Health Center;Funding;Goals;Health;health inequalities;health information technology;health record;Health Services Accessibility;Health system;hormonal contraception;Housing;Implant;implementation cost;implementation design;Improve Access;Individual;Inequity;innovation;Internet;Interview;Latina Population;Lifting;Low income;Low Income Population;marginalization;marginalized population;Medicaid;Methods;Modality;Neighborhood Health Center;pandemic disease;Patient Preferences;Patient Self-Report;Patients;Pattern;Persons;Pharmaceutical Preparations;Population;Poverty;preference;Pregnancy Rate;programs;Provider;Quality of Care;Reproductive Health Services;response;Risk;Role;Rural;safety net;Sampling;screening;service uptake;Services;Shapes;Social Conditions;Socioeconomic Status;Structure;Surveys;System;Technology;telehealth;Telemedicine;Uninsured;unintended pregnancy;uptake;Visit;Woman;women of color;Work;World Health

PROJECT_TITLE: ACCESS: Advancing Contraceptive Equity and Service Uptake through Telemedicine in the US Safety-Net, 2019-2025

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-P (91)]


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cancer;Precision Medicine;Urologic Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The successful outcome of this proposal is the development of much needed quantitative translational imaging biomarkers of neoadjuvant chemotherapeutic efficacy in muscle invasive bladder cancer that have been validated in clinically pertinent patient derived xenografts. The findings of this research project would pave the way for implementation of imaging markers to monitor response of muscle invasive bladder cancer to neoadjuvant chemotherapy to facilitate tailored application of toxic therapy for better tangible clinical outcomes. While this project focuses on neoadjuvant chemotherapy of cisplatin+gemcitabine combination in bladder cancer, the proposed quantitative metabolic imaging technique could ultimately benefit the clinical management of other cancers and drugs.

PI_NAMEs: SRIRAM, RENUKA  (contact)

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: Adjuvant Chemotherapy;Apoptosis;Biochemical;Biological;Biological Assay;Biological Markers;California;cancer initiation;cancer therapy;CASP3 gene;Cellularity;Chemoresistance;chemotherapy;Chemotherapy-Oncologic Procedure;Cisplatin;Clinical;clinical application;Clinical Management;Clinical Research;Clinical Trials;clinically relevant;cofactor;combinatorial;comorbidity;Data;Development;Diagnosis;early detection biomarkers;Enzymes;experimental study;follow-up;Future;gemcitabine;genomic biomarker;Glycolysis;Goals;Hematoxylin and Eosin Staining Method;Image;image translation;imaging approach;imaging biomarker;imaging probe;Imaging Techniques;Immunohistochemistry;improved;In complete remission;in vivo monitoring;Information Systems;Infrastructure;Institution;Lactate Dehydrogenase;Lymph Node Dissections;Magnetic Resonance;Magnetic Resonance Imaging;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Measures;Metabolic;metabolic imaging;Metabolism;metabolomics;Molecular;Monitor;Mus;muscle invasive bladder cancer;Neoadjuvant Therapy;Neoplasm Metastasis;new therapeutic target;Nicotinamide adenine dinucleotide;non-muscle invasive bladder cancer;novel;novel strategies;Outcome;overtreatment;Pathologic;Pathway interactions;patient derived xenograft model;patient stratification;Patient-Focused Outcomes;Patients;Pelvic lymph node group;Pharmaceutical Preparations;pre-clinical;Pre-Clinical Model;preclinical study;predicting response;predictive marker;Proliferating;Protein Isoforms;Pyruvate;quantitative imaging;Radical Cystectomy;Recommendation;Recurrence;Reporting;Research Project Grants;Resistance;responders and non-responders;response;San Francisco;Scanning;stable isotope;Staging;Stains;standard of care;Standardization;Survival Rate;therapy resistant;Time;tissue biomarkers;tool;Toxic effect;Translating;translational potential;treatment effect;Treatment Efficacy;treatment response;tumor;tumor progression;Tumor Volume;Universities;Urogenital Cancer;Vesicle

PROJECT_TITLE: Monitoring response of  neoadjuvant therapy in primary bladder cancer using hyperpolarized 13C MRI

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-X (J2)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Eye Disease and Disorders of Vision;Genetics;Infectious Diseases;Precision Medicine

PHR: PROJECT NARRATIVE Uveitis is a significant cause of blindness globally and there are many challenges to diagnose infectious etiologies due to the insensitivity of diagnostic testing and limited sample volumes from the intraocular space. This proposal leverages international collaborators and recent technological advancements in deep sequencing and mass spectrometry to identify pathogens causing uveitis and characterize the host transcriptome in intraocular fluid and interrogate the tears for proteome and metabolite profiles. This study will provide a comprehensive molecular approach to improve the diagnosis of uveitis and deepen our understanding of the host response to improve the characterization of infectious uveitis syndromes through pathogen discovery and contribute to future risk stratification, individualized treatment, and biomarker identification in uveitis.

PI_NAMEs: SHANTHA, JESSICA  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Address;Algorithms;Anti-Infective Agents;Antimicrobial Resistance;Aqueous Humor;Area;Autoimmune;Bacteria;Biological;Biological Assay;Biological Markers;biomarker development;biomarker discovery;biomarker identification;Blindness;Classification;Clinical;clinical examination;Collaborations;Communicable Diseases;Complex;Data;Databases;deep sequencing;Detection;Diagnosis;diagnostic biomarker;Diagnostic Sensitivity;diagnostic strategy;Diagnostic tests;diagnostic tool;Disease;drug development;emerging pathogen;Etiology;Eye;Eye diseases;Foundations;fungus;Future;Gene Expression;Gene Expression Profile;genetic variant;Genomics;Geography;Health;High-Throughput Nucleotide Sequencing;Immune response;Immune system;improved;individualized medicine;Infectious Agent;Inflammation;Inflammatory;Infrastructure;International;Knowledge;Laboratories;Leptospira;Liquid Chromatography;Liquid substance;Locales;Machine Learning;Mass Spectrum Analysis;Medicine;metabolomics;metagenomic sequencing;Methods;Microbe;microbial;microorganism;Molecular;molecular diagnostics;Monkeypox;Morbidity - disease rate;multiple omics;Nature;noninvasive diagnosis;Ophthalmology;Organism;Outcome;pathogen;Pathogen detection;Pathogenesis;Patient-Focused Outcomes;Patients;Play;Policies;Polymerase Chain Reaction;predict clinical outcome;prevent;programs;Proteome;Proteomics;Protozoa;public health priorities;Resistance;risk stratification;RNA;Role;Rubella;Sampling;Seasons;Serology;Site;Specimen;standard of care;Strategic Planning;Syndrome;targeted treatment;Techniques;Technology;Testing;Therapeutic;time of flight mass spectrometry;transcriptome;trend;Uveitis;Variant;Virus;Visual

PROJECT_TITLE: Multi-omics Strategies to Improve Clinical Outcomes in Uveitis


NIH_SPENDING_CATS: Aging;Bioengineering;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: PROJECT NARRATIVE This project aims to utilize advanced OCT imaging data and biomechanical modeling to calculate the mechanical properties of normal and glaucomatous outflow tissues. The relationship between outflow and biomechanical properties as impacted by several glaucoma drugs and treatments will be determined to understand the implications these agents have on glaucoma.

PI_NAMEs: KARIMI, ALIREZA  (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: 3-Dimensional;Address;Affect;Algorithms;Anterior;anterior chamber;aqueous;Aqueous Humor;aqueous humor flow;Basement membrane;Behavior;biomechanical model;biomechanical test;Biomechanics;Blindness;Collagen Fibril;Complex;confocal imaging;Connective Tissue;Coupled;Coupling;Data;Data Correlations;data modeling;deep neural network;Dexamethasone;diagnostic biomarker;digital;Disease;Drainage procedure;Elasticity;Elements;Endothelial Cells;Endothelium;Equilibrium;Evaluation;Extracellular Matrix;Eye;Failure;Glaucoma;Goals;Human;Image;improved;Interleukin-1;kinase inhibitor;Liquid substance;Measures;mechanical properties;Methods;Microspheres;Modeling;Morphology;Motion;neural network algorithm;novel diagnostics;particle;Pathway interactions;Perfusion;Persons;Pharmaceutical Preparations;Physiologic Intraocular Pressure;pressure;Primary Open Angle Glaucoma;Production;Property;Regulation;Resistance;Resolution;response;Rho-associated kinase;Risk Factors;Saponins;Solid;Stress;Structural Models;Structure;Structure of sinus venosus of sclera;Testing;therapeutic biomarker;Time;Tissue membrane;Tissues;Trabecular meshwork structure;Transforming Growth Factor beta;two photon microscopy;Vascular Endothelial Growth Factors;Velocimetries;viscoelasticity;Visible Radiation;Visual

PROJECT_TITLE: Modulation of Outflow Facility and Biomechanics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


ADMINISTERING_IC: OH

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: MENANDS

ORG_NAME: CENTER OF ENVIRONMENTAL HEALTH

PHR: This CDC/NIOSH renewal application, contains three components; an expanded Fundamental component, which in addition to integrating occupational health into other public health initiatives, also includes adult lead poisoning outreach and interventions activities; an Occupational Lung Disease Surveillance component and Fatality Assessment and Control Evaluation (NY FACE) component. For the expanded Fundamental component, data will be collected and incorporated into other public health tracking systems and will be used to identify high-risk industries and occupations, and other populations at high-risk, including adults at risk for lead poisoning. We will continue our work in preventing serious and fatal occupational injuries by conducting the NY FACE program and use data from the NYS Occupational Lung Disease Registry to continue and expand surveillance for occupational lung disease.

PI_NAMEs: FLETCHER, ALICIA  (contact)

PROGRAM_OFFICER_NAME: O'NEILL, EDUARDO

PROJECT_TITLE: Occupational Safety and Health Surveillance in New York State


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_NAME: NEW YORK CITY HEALTH/MENTAL HYGIENE

PHR: PROJECT NARRATIVE The World Trade Center Health Registry contributes to public health by identifying the long-term physical and mental health effects and health care needs of persons directly affected by the World Trade Center disaster. The Registry shares its health findings and recommendations with enrollees, the public, health care providers, scientists, policy makers, and the World Trade Center Health Program. The Registry also provides information about 9/11-related services and offers treatment referral and health promotion opportunities for enrollees.

PI_NAMEs: FARFEL, MARK R (contact)

PROJECT_TITLE: Extension of the World Trade Center Health Registry


ORG_CITY: TOLEDO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS

ORG_STATE: OH

PHR: Project Narrative The MSOH-IH program at the University of Toledo addresses a NIOSH "core discipline", a DHHS Healthy People 2020 Occupational Safety and Health initiative with a focus on prevention/mitigation of work-related human illnesses/ injuries via anticipation, recognition, evaluation, prevention, and control of applicable hazardous agents and factors. The requested funds for 5 years will be used to provide scholarships to graduate students majoring in Industrial Hygiene, who will be prepared for employment as highly qualified, appropriately educated, and trained occupational health and safety specialists in the Northwest Ohio region and elsewhere.

PI_NAMEs: AMES, APRIL  (contact)

PROJECT_TITLE: NIOSH Training Project Grant (TPG): Industrial Hygiene - University of Toledo


NIH_SPENDING_CATS: Cardiovascular;Diabetes

ORG_DEPT: PHARMACOLOGY

PHR: Project Narrative  Cardiovascular disease and stroke claims more lives and costs more money than any other disease in the United States of America. Studies in our laboratory have identified the enzyme glutaminase-1, which metabolizes glutamine to glutamate and ammonia, as a critical regulator of vascular smooth muscle cell function. This project will investigate whether glutaminase-1 contributes to neointima formation following arterial injury, and if it mediates abnormal arterial remodeling, increased arterial stiffness, and hypertension in diabetes.

PI_NAMEs: DURANTE, WILLIAM  (contact)

PROJECT_TERMS: Acid-Base Equilibrium;adenoviral mediated;Ammonia;angiogenesis;Animals;Apoptosis;Arterial Injury;arterial remodeling;arterial stiffness;Arteries;Atherosclerosis;Attenuated;Biological Models;Blood Vessels;Cardiovascular Diseases;Cardiovascular system;Carotid Arteries;cell motility;Cell Physiology;Cell Proliferation;Collagen;cost;Data;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic patient;Disease;DNA biosynthesis;Enzymes;experimental study;Extracellular Signal Regulated Kinases;Fibrosis;Gene Delivery;Gene Transfer;Generations;Genetic;Glucose;Glutamates;Glutaminase;Glutamine;Goals;Growth Factor;heme oxygenase-1;Hypertension;In Vitro;in vivo Model;injured;Insulin-Dependent Diabetes Mellitus;Laboratories;Lesion;Liver Fibrosis;Mediating;Mediator;Metabolism;migration;Mitochondria;mortality;mouse model;neointima formation;neurotransmission;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;overexpression;patient population;percutaneous coronary intervention;pharmacologic;Play;prevent;Process;Production;Proliferating;Proline;Protein Isoforms;Pulmonary Hypertension;Regulation;response;response to injury;restenosis;Risk;Rodent;Role;Seminal;Signal Transduction;Smooth Muscle Myocytes;Stroke;success;Testing;Time;Transcription Factor AP-1;Transcriptional Activation;tumor growth;United States;vascular abnormality;Vascular Diseases;Vascular remodeling;Vascular Smooth Muscle;vascular smooth muscle cell proliferation

PROJECT_TITLE: Glutaminase in Arterial Injury and Disease

STUDY_SECTION: VCMB

STUDY_SECTION_NAME: Vascular Cell and Molecular Biology Study Section[VCMB]


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Sleep Research

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Salient experiences have a high probability of being remembered, yet how salience is incorporated into memories is not well understood. Our research will explore the functions of VTA dopaminergic neurons–a neuronal population critically implicated in encoding salience and learning–in the consolidation of salient memories during sleep. We will use powerful systems neuroscience tools to reveal what facets of experiences alter dopamine signaling during sleep, whether dopamine signaling during post-learning sleep contributes to long-term storage of memories and the nature of interactions between VTA dopamine neurons and hippocampal-dependent memory consolidation processes.

PI_NAMEs: SULAMAN, BIBI ALIKA (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Affect;Anatomy;Animals;Arousal;Behavior;Binding;Brain;Brain region;Calcium;Cells;Communication;Computer Analysis;Data;Data Reporting;Dependence;Development;Disease;Dopamine;dopaminergic neuron;Electrophysiology (science);Environment;Event;experience;experimental study;Food;Head;Hippocampus;Image;innovation;insight;Knowledge;Learning;Life Experience;Link;long term memory;maladaptive behavior;member;Memory;memory consolidation;Memory impairment;memory process;memory recall;Mental disorders;Michigan;Microscope;Molecular;Mus;Nature;Negative Valence;Neurons;Neurosciences;non rapid eye movement;novel therapeutic intervention;novel therapeutics;optogenetics;Pattern;Play;Population;Positive Valence;Post-Traumatic Stress Disorders;Probability;Process;REM Sleep;Research;Research Personnel;Resolution;Role;Sensory;Signal Transduction;skills;Sleep;Stimulus;Substance Use Disorder;Synaptic plasticity;System;Testing;Time;tool;Training;Universities;Ventral Tegmental Area

PROJECT_TITLE: Deciphering the role of VTA dopaminergic signaling in memory consolidation during sleep


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: NARRATIVE Allogeneic haematopoietic stem cell transplantation (HCT) is the standard therapy for several haematological cancers and diseases with more than 30,000 procedures carried out annually worldwide, including in 40 per 100,000 Americans afflicted with life-threatening blood, bone marrow or lymph node cancer. Immune pathology called chronic graft versus host disease (cGVHD) develops in many HCT patients, leading to significant impact on morbidity and survival. Our current research will advance knowledge of cGVHD immune mechanisms in human HCT that will lead to improved treatments for cancer patients, and patients with autoimmune and blood disorders.

PI_NAMEs: SARANTOPOULOS, STEFANIE  (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Address;Affect;Agonist;Allogenic;American;Antibodies;Antigens;Area;attenuation;autocrine;Autoimmune Diseases;Automobile Driving;B-Cell Activation;B-Cell Antigen Receptor;B-Lymphocyte Subsets;B-Lymphocytes;Binding;Biological Assay;Blood;Bone Marrow;Cancer Patient;cancer therapy;Cell Compartmentation;Cell Maturation;Cell Nucleus;Cell Physiology;Cellular Assay;chronic graft versus host disease;Clinical;Clinical Research;Clinical Trials;conditional knockout;cytokine;Data;Data Set;Disease;Effector Cell;Endosomes;Event;experience;experimental study;Exposure to;Funding;G-Protein-Coupled Receptors;Half-Life;Hematologic Neoplasms;Hematological Disease;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Homeostasis;Human;Human Herpesvirus 4;Humoral Immunities;Immune;Immune System Diseases;Immunoglobulin G;Immunotherapeutic agent;improved;Inflammatory;inhibitor;Interleukin 4 Receptor;Interleukin-6;Knockout Mice;Knowledge;Life;Link;Maintenance;Malignant Lymph Node Neoplasm;Malignant Neoplasms;Measures;Mediating;Modeling;Molecular;Morbidity - disease rate;Mus;novel;novel strategies;overexpression;paracrine;Pathologic;Pathology;Pathway interactions;Patients;Peripheral;Phase I Clinical Trials;phase I trial;Phase II Clinical Trials;POU2F2 gene;preclinical study;prevent;Procedures;Production;profibrotic cytokine;Protein Tyrosine Kinase;Proteins;Publishing;receptor;Receptor Activation;Receptor Signaling;Recovery;Research;Research Personnel;response;rituximab;RNA Binding;Role;Sampling;Science;Signal Pathway;Signal Transduction;single-cell RNA sequencing;small molecule inhibitor;Solid;stem cell therapy;SYK gene;System;Testing;therapeutic target;TLR7 gene;Toxic effect;transcription factor;Transplant Recipients;Tumor Immunity;Tyrosine Kinase Inhibitor;Ubiquitination;Work

PROJECT_TITLE: Pathological B Cells: Novel Strategies to Prevent and Treat Chronic GVHD

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease;Microbiome

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Narrative Inflammatory bowel disease affects millions of patients per year in the United States, and it imposes burdens on communities worldwide and drastically reduces patients’ quality of life. Patients with inflammatory bowel disease exhibit disruptions in their intestinal mucus and dysbiosis of the commensal gut microbiome. This proposal aims at demonstrating the function of β1-3-N-acetylglucosaminyltransferase 7 (B3GNT7) in maintaining intestinal mucus and a healthy gut microbiome.

PI_NAMEs: BURNS, MARY WILTON NEWTON (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: 16S ribosomal RNA sequencing;Affect;Anabolism;Bacteria;beneficial microorganism;Biochemical;biophysical properties;biophysical techniques;Biophysics;Cell Line;Cell surface;commensal bacteria;commensal microbes;Communities;Crohn's disease;cytokine;Disease;dysbiosis;enteric pathogen;Exhibits;experimental study;Foundations;Fucose;Future;Gene Cluster;Glycoconjugates;Glycoproteins;glycoproteomics;glycosylation;glycosyltransferase;golgi apparatus membrane;gut inflammation;gut microbes;gut microbiome;gut microbiota;Health;Homeostasis;host microbiome;host microbiota;host-microbe interactions;Human;Human Cell Line;ileum;Inflammation;Inflammatory;Inflammatory Bowel Diseases;inhibitor;insight;interleukin-22;intestinal epithelium;Intestines;Knock-out;Link;Mass Spectrum Analysis;Mediating;Metagenomics;Microbe;microbiome;Modeling;Molecular;Molecular Structure;mouse model;Mucins;Mucous body substance;Mus;N-Acetylglucosaminyltransferases;Nutrient;overexpression;pathogenic microbe;Patients;Pattern;Physiology;Polysaccharides;prevent;Property;Quality of life;Regulation;Reporting;Research;resident commensals;response;Shotguns;Signal Transduction;Site;Small Intestines;Structure;sugar;Sulfate;sulfomucin;Symbiosis;Techniques;Tissues;Ulcerative Colitis;United States

PROJECT_TITLE: The Impact of B3GNT7 on Properties of Intestinal Mucus and the Gut Microbiome


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: WORCESTER

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Project Narrative The development of mature neural circuits requires a significant degree of circuit rewiring. Errors in this rewiring are linked to neurological disorders such as autism spectrum disorders. This proposal aims to characterize conserved pathways and features of synapse remodeling, to elucidate mechanisms responsible for establishing mature circuits in the brain, and potentially to identify gene targets for treatment.

PI_NAMEs: LIU, SAM  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Adolescent;Adult;Affect;Animals;Architecture;autism spectrum disorder;Axon;Birth;Brain;Caenorhabditis elegans;Calcineurin;calcineurin phosphatase;Calcium;Calcium Signaling;Calcium-Binding Domain;Catalytic Domain;Cells;Cholinergic Receptors;Clustered Regularly Interspaced Short Palindromic Repeats;Development;Dorsal;EF Hand Motifs;Engineering;experimental study;Future;gamma-Aminobutyric Acid;gene-targeted therapy;Genes;Genetic;Genetic Transcription;Goals;homeodomain;Homeostasis;Human;Image;Intestines;Invertebrates;Label;Link;loss of function;Maintenance;Masks;Modeling;Molecular;Motor Neurons;multicatalytic endopeptidase complex;Muscle;mutant;Mutation;Nematoda;Nervous System;Nervous System Disorder;neural circuit;Neuroglia;Neurons;null mutation;Operon;Pathway interactions;Phylogeny;Postembryonic;postsynaptic;Presynaptic Terminals;Process;Proteasome Inhibitor;Proteins;Regulation;Role;Schizophrenia;Site;Supine Position;Synapses;Synaptic Receptors;Taxes;Techniques;Tissues;transcription factor;Transcriptional Regulation;transcriptome sequencing;Whole Organism;Work

PROJECT_TITLE: Investigating the Role of cnb-1 and chpf-1 in GABA DD Motor Neuron Remodeling and Synapse Maintenance


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: Traumatic Brain Injury (TBI) is a major cause of death and disability among both civilians and military personnel, with about 1.4 million TBI’s occurring each year in the U.S. For military personnel, between 14-20% of surviving casualties had a TBI. Studies proposed investigate chronic effects of different types of traumatic brain injury, including cognitive decline and early-onset dementia. This work may lead to a new strategy for improving chronic outcomes after TBI.

PI_NAMEs: TOMLINSON, STEPHEN  (contact)

PROJECT_TERMS: Acute;Affect;Affective;age related;Alzheimer's Disease;Amygdaloid structure;Anatomy;Anti-Inflammatory Agents;Astrocytes;Automobile Driving;blood-brain barrier function;Brain;Brain Concussion;Brain Injuries;Brain region;burden of illness;Cause of Death;CD11c Antigens;cell type;Cells;Cerebrum;Characteristics;Chronic;Chronic Phase;chronic traumatic encephalopathy;Clinical;clinically relevant;Closed head injuries;Cognitive;Cognitive deficits;Complement;Complement Receptor;complement system;controlled cortical impact;Contusions;Cytometry;Data;Dementia;dementia risk;design;Diffuse;disability;Disease;early onset;executive function;experience;follow-up;Functional disorder;Gender;Genetic Transcription;Growth Factor;high risk;Hippocampus;imaging study;Immune;immune cell infiltrate;Immunologics;immunomodulatory therapies;Impaired cognition;improved;individualized medicine;Inflammation;Inflammation Mediators;Inflammatory Response;Injury;Knockout Mice;Ligands;Link;Magnetic Resonance Imaging;Mediating;Microglia;Military Personnel;Modeling;Molecular;Mus;Nerve Degeneration;Nervous System Disorder;neurobehavioral;neurobehavioral test;Neurodegenerative Disorders;Neuroimmune;neuroinflammation;Neurologic;neuron loss;Neurons;novel;Outcome;Pathologic;Pathology;Pathway interactions;Patients;Performance;Peripheral;Phagocytosis;Play;post intervention;Prefrontal Cortex;prevent;Production;Proteins;receptor;regional difference;Reporting;response;Risk Factors;Risk Reduction;Role;Serum;Source;Synapses;Synaptic plasticity;System;tau Proteins;Therapeutic;therapy design;Time;Transgenic Mice;Traumatic Brain Injury;treatment strategy;Veterans;Work

PROJECT_TITLE: Role of complement in TBI


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences;Social Determinants of Health

ORG_CITY: COLLEGE PARK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: NARRATIVE A key challenge for psychiatry and clinical psychology is to discover, understand, and ultimately to treat the root causes of the most common and costly mental disorders. The proposed study will harness an innovative combination of state-of-the-art brain imaging techniques and longitudinal measures of symptom progression, function, and real-world experience to identify the neural and behavioral pathways that contribute to the development and recurrence of anxiety disorders and depression—mental illnesses that are common and challenging to treat. This work is a critical step toward the development of new, neurobiologically-grounded strategies for preventing or treating these debilitating emotional disorders.

PI_NAMEs: GROGANS, SHANNON  (contact)

PROJECT_TERMS: Address;Adult;advanced analytics;Affective;Amygdaloid structure;analytical tool;Animals;Anterior;Anxiety;Anxiety Disorders;archived data;Attention;Behavior;Behavioral;biobank;Biological;Black, Indigenous, People of Color;brain circuitry;Brain imaging;career;Cellular Phone;Clinical;Clinical Psychology;Clinical Sciences;Complex;cost;Data;Data Collection;Development;Diagnosis;digital phenotyping;Dimensions;Disease;Disease susceptibility;Distress;Ecological momentary assessment;emerging adult;Emotional;Emotional disorder;Emotions;Enrollment;Ensure;Ethics;ethnoracial;Etiology;Event;experience;Exposure to;Face;Feeling;Functional Magnetic Resonance Imaging;Future;Human;Imaging Techniques;improved;Individual;innovation;Insula of Reil;Interview;Life;Link;longitudinal, prospective study;Maryland;Measures;Mediator;Mental Depression;Mental disorders;Mentors;mHealth;Modeling;Moods;Morbidity - disease rate;negative mood;neural;Neurobiology;neuroimaging;Neurosciences Research;Neurotic Disorders;Panic;Pathology;Pathway interactions;Patient Self-Report;Perception;prevent;Productivity;programs;prospective;Psychiatry;psychosocial;Public Health;Publications;Questionnaires;racial diversity;recruit;Recurrence;Research;Research Ethics;Risk;Risk Factors;Role;Safety;Sampling;Self Medication;sex;Shock;Signal Transduction;skills;social;Social isolation;Social support;Stress;Structure;Symptoms;targeted treatment;Testing;theories;therapeutic development;therapy development;Training;Vulnerable Populations;Withdrawal;Work

PROJECT_TITLE: Using Functional Neuroimaging and Smartphone Digital Phenotyping to Understand the Emergence of Internalizing  Illness


ORG_CITY: CHICAGO

ORG_NAME: JESSE BROWN VA MEDICAL CENTER

ORG_STATE: IL

PHR: L-asparaginase (ASNase) is a biological cancer drug with a unique mode of action, with broad potential use, although it currently is mostly limited to a childhood blood cancer called ALL because the side effects are exacerbated in adults. Our previous work designed and evaluated a new ASNase, predicted to be much better tolerated by adult cancer patients, thus creating multiple potential additional uses beyond ALL. We now also better understand which patients would respond to this drug, allowing us to employ personalized medicine to identify those cancer patients. In this application, we expand ASNase treatment from blood cancers to solid tumors, where we evaluate the efficacy of ASNase in liver cancer, including studies of factors that can lead to drug resistance. This combination of our new and safer ASNase (which will permit use by the adult VA patient population), with a screen that predicts which patients would benefit most from this treatment, will impact the treatment of Veterans with liver cancer and other solid tumor cancers such as gastric and AML.

PI_NAMEs: LAVIE, ARNON  (contact)

PROJECT_TERMS: acute lymphoblastic leukemia cell;Acute Lymphocytic Leukemia;Acute Myelocytic Leukemia;Adult;Amino Acid Transporter;Amino Acids;Antineoplastic Agents;asparaginase;Asparagine;Aspartate-Ammonia Ligase;Biological;Biological Markers;biomarker validation;Biopsy;Blood;blood treatment;cancer cell;Cancer cell line;Cancer Patient;cancer type;Cell Line;Cells;Childhood;Childhood Acute Lymphocytic Leukemia;Clinical;Clinical Trials;clinically relevant;comparison control;Data;design;Development;Drug resistance;Drug Side Effects;efficacy evaluation;Engineering;Enzymes;FDA approved;Funding;Genetic;genomic signature;Genomics;Glutaminase;Goals;Hematopoietic Neoplasms;hepatocellular carcinoma cell line;Human;Human Engineering;Hypermethylation;Immune response;immunogenic;improved;improved outcome;In Vitro;in vivo;Malignant Epithelial Cell;Malignant neoplasm of liver;Malignant Neoplasms;malignant stomach neoplasm;Messenger RNA;Methylation;military veteran;Minority;Minority Groups;Mus;Nature;neoplastic cell;novel;novel strategies;Organoids;patient derived xenograft model;patient population;Patient Selection;patient stratification;Patients;Pegaspargase;personalized medicine;Phagocytosis;Pharmaceutical Preparations;pre-clinical;predicting response;predictive signature;predictive test;Predisposition;Prevalence;prevent;Primary carcinoma of the liver cells;promoter;Reagent;Reporting;Resected;Resistance;response;response biomarker;Safety;Sampling;Side;side effect;Solid Neoplasm;standard of care;Starvation;Stomach;success;Testing;theories;Therapeutic;tool;Toxic effect;Translating;treatment comparison;tumor;Tumor Volume;Up-Regulation;Validation;validation studies;Veterans;Work

PROJECT_TITLE: Expanding the efficacy of asparaginase to solid tumors


NIH_SPENDING_CATS: Cardiovascular;Digestive Diseases;Heart Disease;Heart Disease - Coronary Heart Disease;Liver Disease;Nutrition

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Intermittent fasting and caloric restriction are newly identified, effective means through to treat secondary cardiomyopathies. We identified trehalose-class compounds as pharmacological mimetics of the adaptive fasting response, which also attenuate the pathological growth, gene expression and cardiac dysfunction that is induced by chronic pressure overload. Using broad cardiomyopathic stimuli and detailed mouse genetic approaches in the current proposal, we will examine signaling mechanisms and clinical contexts in which hepatic glucose fasting responses can be leveraged against secondary cardiomyopathies.

PI_NAMEs: DEBOSCH, BRIAN JESSE (contact)

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: analog;aorta constriction;Attenuated;Autophagocytosis;Caloric Restriction;Cardiac;Cardiac Myocytes;Cardiometabolic Disease;Cardiomyopathies;cardioprotection;cardiovascular risk factor;Cardiovascular system;Catabolism;Chronic;Clinical;Clinical Trials;clinically relevant;Data;Disaccharides;Disease;disease model;efficacy evaluation;Fasting;fasting glucose;Fatty Liver;FGF21 gene;fibroblast growth factor 21;Functional disorder;Gene Expression;genetic approach;Germ Lines;glucose metabolism;glucose transport;Glucose Transporter;Goals;Growth;Growth Factor Receptors;Heart Diseases;Heart failure;Hepatic;Hepatocyte;Hormone secretion;Human;Hypertrophy;improved;Infarction;inhibitor;innovation;Insulin Resistance;Intermittent fasting;Ischemia;Laboratories;Left Ventricular Hypertrophy;Light;Liver;Metabolism;microbial;mimetics;Modeling;mortality;mouse genetics;mouse model;Mus;Myocardial dysfunction;Myocardial Infarction;Myocardial Ischemia;Myocardial Reperfusion Injury;Myocardium;next generation;novel;novel therapeutics;Nutraceutical;Oral;Pathologic;Pathway interactions;Patients;peptide hormone;pharmacologic;pressure;prevent;Publishing;Reagent;Receptor Signaling;Reperfusion Injury;Reperfusion Therapy;Resistance;response;Rodent;Secondary Myocardial Diseases;Signal Transduction;small molecule;Stimulus;Techniques;Testing;Therapeutic;Therapeutic Effect;Therapeutic Intervention;tool;Trehalose;Work

PROJECT_TITLE: Treating secondary cardiomyopathies by mimicking the adaptive hepatic glucose fasting response

STUDY_SECTION: MIM

STUDY_SECTION_NAME: Myocardial Ischemia and Metabolism Study Section[MIM]


ORG_CITY: SAN ANTONIO

ORG_NAME: SOUTH TEXAS VETERANS HEALTH CARE SYSTEM

PHR: Insomnia is a common sleep disturbance in service members and veterans and is especially prevalent in individuals with a history of traumatic brain injury. Long-term untreated insomnia can lead to a wide range of negative health concerns such as mood and anxiety disorders, respiratory and neurologic conditions, chronic pain, cardiovascular disease, and diabetes. Although cognitive behavioral therapy is the gold standard treatment for insomnia, not all individuals respond to the treatment. This research will examine the mechanisms associated with cognitive behavioral therapy effectiveness in military service members with insomnia and history of traumatic brain injuries. Improving sleep is the first critical step in optimizing and enhancing rehabilitation approaches in veterans, and our results could provide tractable solutions to strengthen existing rehabilitation or identify novel therapeutic approaches.

PI_NAMEs: MITHANI, SARA  (contact)

PROJECT_TERMS: active duty;Adult;Age;age effect;age related;age related chronic disease;alertness;Anxiety;Anxiety Disorders;beneficiary;Bioinformatics;Blast Injuries;Blood;Blood specimen;Brain Injuries;Cardiovascular Diseases;Caring;Categories;CCL4 gene;Cerebrovascular Disorders;Chronic;chronic pain;Chronic Phase;Classification;Clinical assessments;clinically significant;Cognitive Therapy;cohort;Collection;common symptom;comorbidity;Conscious;Coupled;Cytokine Gene;daily functioning;Dementia;Development;Diabetes Mellitus;Diagnosis;differential expression;Disease;Effectiveness;Enrollment;Evaluation;experience;Funding;Gender;Gene Expression;Gene Expression Profiling;Genes;genetic signature;Health;Health Policy;Healthcare Systems;Human Resources;Hypertension;Immune;Immunocompetence;Impaired cognition;Impairment;improved;improvement on sleep;indexing;Individual;Inferior;Inflammation;Inflammatory;insight;Interleukin-1 beta;Interleukin-13;Interleukin-6;Laboratories;Link;Matched Group;Medicine;men;Mental Depression;Mentors;Military Personnel;military service;military veteran;Molecular;Monitor;Mood Disorders;Neurologic;new therapeutic target;novel;novel therapeutic intervention;older adult;Outcome;Participant;Pathway interactions;Patients;peripheral blood;Personal Satisfaction;Pharmaceutical Preparations;Pilot Projects;Population;Post-Traumatic Stress Disorders;potential biomarker;prognostication;programs;Proxy;Quality of life;randomized trial;Recording of previous events;rehabilitation strategy;Rehabilitation therapy;Research;research clinical testing;respiratory;response;Risk;Screening procedure;service member;Severities;sex;skills;Sleep;Sleep Disorders;Sleep disturbances;sleep quality;Sleeplessness;standard care;Symptoms;System;systemic inflammatory response;TBI Patients;Testing;TNF gene;Training;Training Programs;transcriptome sequencing;Traumatic Brain Injury;Traumatic Brain Injury recovery;Veterans;Whole Blood;Woman

PROJECT_TITLE: Molecular Mechanisms Associated with Insomnia and Response to Cognitive Behavioral Therapy for Insomnia


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: This project aims to understand the long-term impacts of disasters on Hospital Systems Serving Health Disparities Populations (HSSHDPs), and in turn contribute insightful recommendations for improvements in disaster preparedness. HSSHDPs are embedded within their communities and understand the myriad challenges faced by the people they serve and play a pivotal role in reducing health disparities resulting from disasters. In the long-term, by implementing recommendations that address concerns of such hospital systems, the populations will be better served, thereby, positively impacting overall public health.

PI_NAMEs: GORALNICK, ERIC ;WEISSMAN, JOEL S. (contact)

PROGRAM_OFFICER_NAME: PATEL, ANURADHA DIPAK

PROJECT_TERMS: Address;Administrator;Affect;American Hospital Association;Case Study;Characteristics;climate disaster;Communities;Complex;Consensus;COVID-19;COVID-19 pandemic;COVID-19 pandemic effects;Data Sources;design;Disasters;Emergency Situation;Engineering;ethnic minority;Event;experience;Face;Financial cost;Frequencies;Future;Goals;Health;Health Care Coalitions;health disparity populations;Health protection;Health Status;Health system;Healthcare;Healthcare Systems;Hospitals;improved;innovation;Intervention;Interview;Investigation;lens;Link;long term consequences of COVID-19;long term COVID-19 pandemic impacts;Long-Term Effects;Longitudinal Studies;man-made disasters;Medicaid;Medical;Medicine;member;Methods;Morbidity - disease rate;mortality;Nature;operation;Outcome;outcome disparities;pandemic disease;patient population;Patients;Persons;Play;Policies;policy recommendation;Population;Preparation;programs;promote resilience;Public Health;racial minority;Readiness;Recommendation;Recovery;Reduce health disparities;resilience;Resources;response;Role;Sampling;Services;severe weather;social;societal costs;stressor;Structure;success;Surveys;System;Time;underserved community;Uninsured;United States National Academy of Sciences;Variant;virtual;Vulnerable Populations;weather-related disaster;Work

PROJECT_TITLE: Disasters and Hospital Systems Serving Health Disparity Populations: Identifying the Long Term effects of the COVID-19 Pandemic to Mitigate Future Challenges

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Gender minority people of color face disparities in health and wellbeing, which have been attributed (at least in part) to the negative impact of minority stress on health, while perceived social support has been shown to be protective. This study will examine the social support networks of gender minority people of color both qualitatively and quantitatively, and identify strengths and weaknesses in social connectedness that moderate the relationship between minority stress, health and wellbeing. Findings will inform the future development of interventions to reduce social isolation, promote resilience, and improve health and healthy aging.

PI_NAMEs: BOCKTING, WALTER O. (contact)

PROGRAM_OFFICER_NAME: HERREN, OLGA MARINA

PROJECT_TERMS: Achievement;adult of color;Affect;Age;Age Years;Aging;aging biomarker;Area;Attention;Birth;Black race;Buffers;Characteristics;Cities;cognitive interview;cohort;Communities;Country;Data;Disparity;ethnic minority population;ethnic minority status;Ethnic Origin;experience;Face;Female;follow-up;Frequencies;Future;Gender;gender diversity;gender expression;Gender Identity;gender minority;gender minority group;Gender Relations;General Population;Geography;Goals;Health;health disparity;health disparity populations;healthy aging;improved;Individual;information gathering;Institutional Racism;instrument;Intervention;Interview;Investigation;Knowledge;Length;male;Mental Health;metropolitan;Minority;Minority Groups;minority stress;Modeling;New York City;nonbinary;Not Hispanic or Latino;Outcome;Patient Self-Report;people of color;Personal Satisfaction;Persons;physical conditioning;Policies;Population;promote resilience;Protocols documentation;psychological distress;Race;racial minority;racial minority population;racism;Recording of previous events;recruit;Reporting;Research;resilience;Role;saliva sample;Sampling;Series;sex;Shapes;Site;social;social disparities;Social isolation;Social Network;social stigma;social stress;social structure;Social support;Stress;stressor;Structure;telomere;therapy development;Time;tool;transgender;Unemployment;virtual;Woman

PROJECT_TITLE: Social Connectedness and Health among Gender Minority People of Color

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-P(90)S]


PHR: NARRATIVE The rapid recruitment of white blood cells to sites of tissue injury or infection is a vital determinant of health and its deregulation can lead to chronic disease. This proposal aims at understanding how chemotactic signals are packaged and propagated between neighboring neutrophils, a type of white blood cell critical to innate immunity responses, as they are being recruited to sites of injury or infection. We propose to identify the mechanisms by which exosomes, which are small membrane-bound elements with a key role in signal propagation, are being generated intracellularly from multivesicular bodies using cell biological, biochemical and genetic approaches.

PI_NAMEs: HANSON, PHYLLIS I;PARENT, CAROLE ANNE (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Actins;Actomyosin;Acute;Adopted;Adult;Affinity;Arachidonate 5-Lipoxygenase;Arachidonic Acids;Architecture;Autoimmune;Automobile Driving;Back;Binding;Biochemical;Biogenesis;Biological;biological systems;Blood;Blood Vessels;Cell membrane;cell motility;Cell Nucleus;Cells;Chemotactic Factors;Chemotaxis;Chronic Disease;Complex;constriction;Cues;Cytoskeleton;Diameter;Disease;driving force;Electron Microscopy;Elements;Embryonic Development;Endocytosis;Endosomes;Enzymes;Exhibits;exosome;Exposure to;FPR1 gene;Generations;genetic approach;Golgi Apparatus;health determinants;Homeostasis;Human;immune health;Immune response;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Injury;Innate Immune Response;insight;Integral Membrane Protein;Invaded;Knowledge;lamin B receptor;lamin B2;lamin C;Lamin Type A;Left;leucyl-phenylalanine;Leukocytes;Leukotriene A4;leukotriene A4 hydrolase;Leukotriene B4;Lipids;Lobular;LTB4R gene;Membrane;Membrane Microdomains;meter;migration;Morphology;Multivesicular Body;mutant;Natural Immunity;Necrosis;neutrophil;Neutrophil Infiltration;novel;Nuclear;Nuclear Envelope;Organelles;pathogen;Pathologic Processes;Pathway interactions;Phospholipase A2;Physiological Processes;Process;Production;Property;Proteins;Reaction;recruit;Reporter;response;Role;Signal Pathway;Signal Transduction;Site;Source;Sphingolipids;Testing;tissue injury;Tissues;trafficking;Vesicle;Visualization

PROJECT_TITLE: Signal relay during directed cell migration

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research;Youth Violence

ORG_CITY: MINNEAPOLIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Asian American, Native Hawaiian, and Pacific Islander (AANHPI) sexual and gender minority youth face substantial health disparities; however, misconceptions and insufficient information contribute to disparities and unmet needs. This mixed methods study using an intersectionality framework is directly responsive to calls for research to identify drivers of health disparities in AANHPI youth that link individuals to multiple types of stressors and supports (peers, family, community). This project will use rigorous quantitative and qualitative approaches to challenge misconceptions, fill key research gaps, and offer concrete intervention recommendations to improve community-centered health and wellness for AANHPI youth in intersecting marginalized social positions.

PI_NAMEs: RIDER, G. NIC  (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: 19 year old;Address;Adolescent;adolescent health;Affect;Age;American;Ancillary Study;Area;Asian Americans;bullying;California;Caring;Cause of Death;Characteristics;Child;cisgender;Communities;Complex;Data;Data Set;design;Development;Disadvantaged;Disparity;emotional distress;epidemiology study;Ethnic Origin;Ethnic Population;experience;Exposure to;Face;Family;Feeling;Funding;Future;Gender;Gender Identity;gender minority group;gender minority youth;girls;Health;health disparity;health equity;Health Professional;Health Services;high risk;high risk sexual behavior;Homophobia;Immigrant;improved;Individual;Inequality;innovation;insight;intersectionality;Intervention;Interview;Language;lens;Lesbian;Lesbian Gay Bisexual Transgender Queer;Link;Lived experience;marginalization;Measures;Mediating;Mental Health;Mentorship;Methods;Minnesota;Minority;Modeling;Native Hawaiian or Other Pacific Islander;Neighborhood Health Center;nonbinary;peer;Personal Satisfaction;Persons;Population;Process;Production;protective factors;Protocols documentation;Public Health;public health intervention;queer;Race;racism;Recommendation;Religion;Reporting;Research;resilience;Resources;Risk;Risk Behaviors;Risk Factors;Safety;Sample Size;Sampling;Schools;service providers;Services;Sex Orientation;Sexual and Gender Minorities;sexual minority;sexual minority group;sexual minority youth;social;social factors;Social status;Source;Spirituality;Stereotyping;stressor;structural determinants;Structure;Students;Subgroup;substance use;Suicide;Suicide attempt;Surveys;System;Teenagers;Testing;Training;Training Programs;Variant;Victimization;Work;Youth

PROJECT_TITLE: Exploring health equity for Asian American, Native Hawaiian, and Pacific Islander Adolescents in a large epidemiologic study: Intersections of ethnicity, sexual orientation, and gender identity

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences

PHR: PUBLIC HEALTH SIGNIFICANCE Fear and anxiety disorders imposes a staggering burden on public health and the global economy and existing treatments are far from curative, underscoring the urgency of developing a deeper understanding of the underlying neurobiology. This study will harness an innovative combination of approaches—including brain imaging, state-of-the-art computational techniques, and smartphone digital phenotyping—to understand the architecture of the brain circuits underlying fear and anxiety and determine their relevance to real-world distress, setting the stage for developing more effective brain-based intervention strategies.

PI_NAMEs: SHACKMAN, ALEXANDER JOSEPH (contact)

PROGRAM_OFFICER_NAME: FERRANTE, MICHELE

PROJECT_TERMS: Acute;Address;adjudication;Amygdaloid structure;Anxiety;Anxiety Disorders;anxiety symptoms;Architecture;Arousal;Basic Science;biobehavior;Black, Indigenous, People of Color;Brain;brain based;Brain imaging;Brain region;Categories;Cell Nucleus;Cellular Phone;Classification;Clinical Research;clinically relevant;Communities;Computational Technique;Computer Models;computerized tools;Consensus;Data;data streams;Development;Diagnosis;digital phenotyping;Dimensions;Dissociation;Distal;Distress;Ecological momentary assessment;Fright;Functional Magnetic Resonance Imaging;Galvanic Skin Response;Human;Individual;innovation;interest;Intervention;Lesion;Life;Machine Learning;Maps;Mathematics;Modeling;Moods;Morbidity - disease rate;multidisciplinary;National Institute of Mental Health;Nature;neural;neural circuit;Neuroanatomy;Neurobiology;neuroeconomics;neuroimaging;neuroregulation;novel;Outcome;Pathology;Patients;Pattern;Perception;Performance;Phenotype;Play;predictive modeling;Probability;Psychiatry;Psychopathology;Public Health;racial diversity;recruit;Regional Anatomy;Research;research and development;Research Domain Criteria;Resources;response;Risk;Role;Safety;Sampling;segregation;Series;Signs and Symptoms;Structure of terminal stria nuclei of preoptic region;Symptoms;System;Testing;theories;therapeutic development;therapy development;Time;tool;Training;trait;translational model;Translational Research;Uncertainty;Variant;virtual;Work

PROJECT_TITLE: Using Theory- and Data-Driven Neurocomputational Approaches and Digital Phenotyping to Understand RDoC Acute and Potential Threat


NIH_SPENDING_CATS: Aging;Genetics;Human Genome

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Optimal mitochondrial function is central to human health and disease. We propose to develop tools to study the rich mitochondrial DNA (mtDNA) information in HuBMAP and other single-cell datasets. We will obtain new biological insights into how cell/organ type, aging, gender, race, and other factors impact mtDNA integrity and how mtDNA variants affect cellular gene expression and function.

PI_NAMEs: PEI, LIMING  (contact);WALLACE, DOUGLAS C;XING, YI

PROGRAM_OFFICER_NAME: GALIS, ZORINA S

PROJECT_TERMS: Address;Affect;Age;Aging;aging related disease;Area;ATAC-seq;Biochemistry;Bioinformatics;Biological;Biology;Cardiovascular Diseases;Cell Nucleus;Cell Physiology;cell type;Cells;Cellular biology;cohort;Data;data portal;data resource;Data Set;Databases;Disease;epigenome;Gender;Gene Expression;gene function;Genetic;Genome;genomic data;Health;Human;Human Biology;Human BioMolecular Atlas Program;human data;human disease;Human Genome;Imaging Techniques;Immune;Immune System Diseases;improved;insight;Knowledge;Link;lymph nodes;Maps;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;mitochondrial DNA mutation;mitochondrial genome;multiple omics;neglect;Nerve Degeneration;novel;Nuclear;Organ;Physiology;Race;Research Personnel;Resolution;Resources;RNA;Role;single cell ATAC-seq;single cell genomics;single-cell RNA sequencing;Spleen;Technology;Testing;Thymus Gland;Tissues;tool;transcriptome;Variant;Visualization software

PROJECT_TITLE: Novel biological insights by utilizing mitochondrial genome information from HuBMAP resources


ORG_CITY: BRONX

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

ORG_STATE: NY

PHR: Traumatic brain injury (TBI) is linked to chronic mental health problems including post-traumatic stress disorder (PTSD) in veterans. In many veterans symptoms persist or progress. TBI is also a risk factor for later development of neurodegenerative diseases. Fear learning has been extensively studied in rodents for its relevance to the pathobiology of human PTSD. These studies will examine the molecular basis for why blast exposure affects fear responses using a rat model designed to mimic human mild TBI or subclinical blast exposure.

PI_NAMEs: ELDER, GREGORY A. (contact)

PROJECT_TERMS: adeno-associated viral vector;Affect;Afghanistan;Amygdaloid structure;Anatomy;Animals;antagonist;Anterior;Appearance;Behavior;Behavioral;behavioral phenotyping;Biological Models;blast exposure;Blast Injuries;Brain;Brain Injuries;Brain-Derived Neurotrophic Factor;Cell Nucleus;Cells;Chronic;Cognitive;Collaborations;Cues;decubitus ulcer;Dendritic Spines;Department of Defense;Dependence;Development;differential expression;DLG4 gene;Down-Regulation;EP300 gene;Exhibits;Exposure to;Extinction;Female;Fright;Gene Expression;Genes;Genetic Transcription;Glutamates;Hippocampus;histone modification;Human;Immediate-Early Genes;Immunohistochemistry;improved;Injections;Injury;insight;Iraq;knock-down;Learning;Link;male;Maps;Mediating;Mental Health;metabotropic glutamate receptor 2;mild traumatic brain injury;model design;Modeling;Molecular;Monitor;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;Neurobiology;Neurodegenerative Disorders;Pattern;Phenotype;Post-Concussion Syndrome;Post-Traumatic Stress Disorders;Process;Proteins;psychologic;psychological stressor;Rattus;receptor;Recording of previous events;Research Personnel;response;Risk Factors;RNA;Rodent;Role;Signal Transduction;Site;spinophilin;Structure;Study models;Symptoms;Synapses;Synaptophysin;Synaptosomes;Testing;Thinness;Time;Tissues;TNF gene;trait;transcriptome;transcriptomics;Trauma;Traumatic Brain Injury;Veterans

PROJECT_TITLE: Effects of repetitive low-level blast exposure on fear learning and extinction in a rat model of mild traumatic brain injury