NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Fetal Tissue;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: Newark

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: NARRATIVES In order to understand the fundamental human oligodendrocyte development, pathology, and ultimately to discover drug candidates with higher confidence, it is necessary to develop protocols in human-based platform. Single-cell RNA sequencing comparing mouse and human oligodendrocyte precursor cells (OPCs) revealed a compelling unique sub-population in human OPCs that express signature genes associated with synaptic development, organization, and transmission, suggesting neuron-oligodendrocyte communication during synaptic development. This proposal will establish concrete evidence for human-specific OPC sub- population and its role in synaptic development using single-cell RNA sequencing, spatial transcriptomics, high-resolution histology, and electrophysiology.

PI_NAMEs: NOBUTA, HIROKO  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Ablation;Action Potentials;Adherent Culture;Antibodies;Architecture;Area;Bar Codes;Biological Assay;Biology;Brain;brain tissue;Cell Culture Techniques;Cell Maturation;Cells;Central Nervous System;Cerebrum;clinical translation;Coculture Techniques;Communication;Communities;Complementary DNA;Data;Data Set;Development;Diphtheria Toxin;Disease;drug candidate;drug testing;effective therapy;Electrophysiology (science);experimental study;fetus cell;Formulation;Foundations;Funding;Future;Generations;Genes;genetic signature;Grant;Histologic;Histology;Human;human tissue;In Vitro;Institutional Review Boards;Intellectual functioning disability;Knowledge;leukodystrophy;Live Birth;Maps;Measurement;Mediating;Methods;Molecular;Morphology;Multiple Sclerosis;Mus;Myelin;Names;Nervous System Physiology;Neuroglia;Neurologic Dysfunctions;neuron development;Neurons;neuropsychiatric disorder;novel;novel therapeutics;oligodendrocyte progenitor;Oligodendroglia;Ontology;Pathology;Patients;postsynaptic;precursor cell;Pregnancy;Premature Birth;Premature Infant;presynaptic;Protocols documentation;Regulation;Reporting;Resolution;Rodent;Rodent Model;Role;Secure;Signal Transduction;single-cell RNA sequencing;Slice;Slide;Source;spatial relationship;Synapses;synaptic function;System;Testing;THBS2 gene;Tissue Donors;Tissues;transcriptomic profiling;transcriptomics;transmission process;Universities;Ventricular;white matter injury;WNT5A gene;WNT7A gene

PROJECT_TITLE: Spatial and Single Cell Transcriptomics Approach to Understand Neuron-Oligodendrocyte Communication in Human Synaptic Development


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative. From high-resolution spatial cell transcriptional profiling in glioma tissue slices with intact biological architecture and direct assessment in vivo to cell-specific targeted gene knockdown in a mimicked glioma microenvironment in vitro and back to assessments in glioma models in vivo, we propose to characterize mechanisms of cell fusion/TNT formations as the sources of glioma heterogeneity and intercellular gene transfers. Prognostic profiles of established and novel biomarkers of cell-fusion/TNT formation in the context of a complex glioma microenvironment will be established for different glioma subtypes. The HuR-dependent axis in the regulation of cell fusion/TNT formation at different environmental stress modalities (to include hypoxic, mechanical, metabolic, and cytotoxic stress) will be explored; the quantitative values of HuR inhibitors, including the newly developed and recently patented by our group inhibitor of HuR dimerization SRI4212, in the suppression of the cell fusion and glioma heterogeneity will be provided.

PI_NAMEs: FILIPPOVA, NATALIA ;NABORS, LOUIS B (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: Amino Acids;Architecture;Autophagocytosis;Back;Binding Proteins;Biological;Biological Markers;Brain;Cell Communication;Cell fusion;Cell Line;cell mediated gene transfer;Cell Survival;cell transformation;cell type;Cells;Cellular Assay;Cellular Stress;Cerebrum;Clustered Regularly Interspaced Short Palindromic Repeats;Compensation;Complement;Complex;Cytoplasm;Cytoskeleton;cytotoxic;Data;Data Analyses;Development;Dimerization;Disadvantaged;Dissection;Dissociation;Drug resistance;ELAV protein;Event;experimental study;extracellular vesicles;Family;Female;Flow Cytometry;Fluorescence;Gene Expression Profiling;Gene Transfer;Genes;Genetic Transcription;genome wide screen;genome-wide;genome-wide analysis;Genomic Instability;Genomics;Genotype;Glioblastoma;Glioma;Grant;Guide RNA;Heterogeneity;Histologic;Horizontal Gene Transfer;Human;Human Genome;HuR protein;Hypoxia;Immunocompetent;Immunocompromised Host;Immunologics;In Vitro;in vivo;in vivo Model;Inflammatory;inhibitor;knock-down;Knock-out;knockout gene;Lead;Legal patent;Libraries;male;Mass Spectrum Analysis;Mechanical Stress;Mechanics;Mediating;Membrane;Membrane Fusion;Messenger RNA;Metabolic;Microfluidics;Mitochondria;Modality;Modeling;Molecular;Molecular Analysis;molecular subtypes;multimodality;Mus;Nanotubes;neoplastic;Normal Cell;novel;novel marker;Nutrient;Organoids;Outcome;overexpression;Patient-Focused Outcomes;Patients;pharmacologic;Phenotype;Phosphatidylserines;Process;prognostic signature;protein complex;Proteins;proteomic signature;Proteomics;receptor;Regulation;Reporter;Resolution;RNA-Binding Proteins;Role;screening;Signal Pathway;Signal Transduction;Signaling Protein;Slice;Source;Stress;Surface;Techniques;therapy development;therapy resistant;Tissues;transcriptome;transcriptome sequencing;transcriptomics;Tube;tumor;tumor heterogeneity;Up-Regulation

PROJECT_TITLE: ELAVL1 role in glioblastoma heterogeneity through intercellular gene transfer mediated by cell fusion and tunneling membrane nanotube formation

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Complementary and Integrative Health;Dietary Supplements;Nutrition;Obesity;Precision Medicine;Prevention

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PI_NAMEs: LEE, MI JEONG  (contact)

PROJECT_TERMS: Acyltransferase;Adipocytes;adiponectin;Adipose tissue;Affect;Animal Model;Animals;Berry;Bioenergetics;Biological Models;Brown Fat;Cardiometabolic Disease;cardiometabolic risk;Cells;Chronic;Critical Pathways;cytokine;Data;Dietary Factors;Dietary Fats;Endocrine;Endocrine Glands;Energy Metabolism;Enzymes;Fatty acid glycerol esters;fatty acid supplementation;Fatty Acids;Fish Oils;Food;Generations;Genes;Goals;Health;Health Benefit;High Fat Diet;Homeostasis;Human;Impairment;improved;in vivo;Inflammation;Inflammatory;Inflammatory Response;insulin signaling;knock-down;Knockout Mice;lard;Lead;lipid metabolism;lipidome;Lipids;Lysophosphatidylcholines;Mediating;Membrane;Membrane Biology;Mentors;Metabolic;Metabolic Diseases;Metabolism;Molecular;Monounsaturated Fatty Acids;mouse model;new therapeutic target;novel;nutrition;Obesity;Omega-3 Fatty Acids;Outcome;Overnutrition;Pathway interactions;Persons;Phospholipid Metabolism;Phospholipids;Physiological;Play;Polyunsaturated Fatty Acids;precision nutrition;prevent;Production;professor;Property;protective effect;Public Health;Quality of life;response;Risk;Rodent Model;Role;saturated fat;Saturated Fatty Acids;Science;Signaling Molecule;Testing;Texas;Therapeutic;Tokyo;transcriptome;uncoupling protein 1;Work

PROJECT_TITLE: Project 2: Role of LPCAT3 in Adipose Remodeling and Metabolic Diseases


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hepatitis;Liver Disease;Nutrition;Precision Medicine;Prevention

PI_NAMEs: RETTENMEIER, CHRISTOPH ALEXANDER (contact)

PROJECT_TERMS: Address;Adverse effects;Affect;Benign;Berry;Biopsy;Blood;career;career development;Centers of Research Excellence;Characteristics;Chemistry;Cirrhosis;Clinical assessments;clinical diagnosis;clinical phenotype;Collaborations;Collagen;Communities;density;Deposition;Development;Diagnosis;Diagnostic;diagnostic tool;Diet Habits;dietary control;Disease Outcome;disease phenotype;Disease Progression;Doctor of Philosophy;Economic Burden;effectiveness evaluation;Extracellular Fluid;Extracellular Matrix;Fatty acid glycerol esters;Ferritin;fibrogenesis;Fibrosis;Funding;Goals;Hawaii;Health;Health Benefit;healthy volunteer;Hemosiderin;Hepatic;Hepatic Tissue;Histologic;Human;Image;Imaging Techniques;Imaging technology;improved;Individual;Inflammation;Insulin Resistance;interest;Intervention;Iron;Iron Compounds;Iron Overload;life time cost;Liver;liver biopsy;Liver diseases;Liver Fibrosis;liver imaging;liver transplantation;low socioeconomic status;Magnetic Resonance Elastography;Magnetic Resonance Imaging;Magnetism;Malnutrition;Maps;Measurement;Measures;Medical center;Medicine;member;Mentors;Methods;minimal risk;Modeling;Monitor;mortality;Motion;Nature;non-alcoholic fatty liver;non-alcoholic fatty liver disease;non-invasive imaging;nonalcoholic steatohepatitis;noninvasive diagnosis;novel;novel strategies;nutrition;Obesity;Onset of illness;Overnutrition;pandemic disease;patient population;Patients;Performance;Personal Satisfaction;Pilot Projects;Population;precision nutrition;Predisposition;Primary carcinoma of the liver cells;Protons;Radial;Reference Values;Research;Research Personnel;research study;Resources;Risk Assessment;Risk Factors;Risk Reduction;Sampling;Scanning;screening;Secure;sedentary lifestyle;Severities;Severity of illness;Specificity;Techniques;Testing;Tissues;tool;United States;United States Department of Agriculture;Universities;Validation

PROJECT_TITLE: Project 3: A Novel Simultaneous Multiparametric MRI Approach for the Quantitative Assessment of Non-alcoholic Fatty Liver Disease


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The goal of this project is to generate novel probes to visualize how tubulin, a molecule that is the basic unit of the axonal cytoskeleton, is delivered to axons and is later removed. This is important to understand how neurons maintain the cytoskeletal mass of their axons. Since reduced cytoskeletal mass is a hallmark of several neurological diseases, results from this study may provide important insights into disease mechanisms.

PI_NAMEs: YOGEV, SHAUL  (contact)

PROJECT_TITLE: Visualizing axonal delivery and removal of tubulin

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: NEW YORK

ORG_DEPT: PEDIATRICS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE There is a high genetic risk for asthma that changes sphingolipid production, and sphin- golipids may play an essential and yet unknown role in developing this common disease. We will study how rhinovirus, the most common trigger for asthma attacks, affects sphin- golipid production in children with asthma, and this will help us understand critical factors of the disease that can be useful for new therapies.

PI_NAMEs: WORGALL, STEFAN  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: 17q21;Adult;Affect;Agonist;Air;airway epithelium;airway hyperresponsiveness;Animal Model;Asthma;asthma exacerbation;asthmatic;asthmatic airway;biobank;Blood;Cell model;Cells;Cellular Stress;Child;Childhood Asthma;chronic respiratory disease;Coenzyme A-Transferases;cohort;Complex;constriction;Data;Development;dihydrosphingosine 1-phosphate;Disease;early childhood;Enzymes;Epithelial Cells;Etiology;Gene Expression;Genetic;Genetic Polymorphism;Genetic Predisposition to Disease;Genetic Risk;Genotype;High Pressure Liquid Chromatography;Human;Immune response;Impairment;In Vitro;Incidence;Infection;Innate Immune Response;Knowledge;Label;Link;Liquid substance;Lung;Mediating;Mediator;Metabolic;Metabolic Pathway;Metabolism;monocyte;mouse model;Mus;Nasal Epithelium;new therapeutic target;Nose;novel;novel therapeutic intervention;novel therapeutics;Palmitoyl Coenzyme A;Pathogenesis;Pathway interactions;pharmacologic;Play;Production;repository;Resolution;respiratory;Respiratory System;Respiratory Tract Infections;response;Rhinovirus;Rhinovirus infection;Risk;risk variant;Role;Serine;Shapes;Slice;Sphingolipids;sphingosine 1-phosphate;Sphingosine-1-Phosphate Receptor;Stable Isotope Labeling;Subgroup;Susceptibility Gene;tandem mass spectrometry;Testing;transcriptome sequencing;Variant;Viral;Viral Respiratory Tract Infection;Work

PROJECT_TITLE: Respiratory sphingolipid synthesis involved in airway hyperreactivity and viral-triggered asthma

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Infectious Diseases;Lung;Nanotechnology;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_CITY: IOWA CITY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Antibiotic resistant Staphylococcus aureus infections remain a major global health problem. S. aureus infect their host by adapting their physiology to the environment found at sites of infection. The main objective of this proposal is to determine the mechanism(s) by which the SrrAB signaling pathway regulates the ability of S. aureus to adapt to the host environment and infect humans.

PI_NAMEs: FUENTES, ERNESTO JORGE (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Aerobic;Animals;Antibiotic Resistance;Antibody Formation;Bacteria;Binding;Binding Sites;Biochemical;Biological;Biological Assay;Biological Process;biophysical techniques;Catalytic Domain;Cell membrane;Cells;Cessation of life;combat;Communities;Complex;cost;Cryoelectron Microscopy;Cysteine;Cytoplasm;Data;design;Disease;Disulfides;Drug Metabolic Detoxication;Environment;enzyme activity;Enzymes;extracellular;Fermentation;Gene Expression;Genes;genetic approach;Genus staphylococcus;global health;Goals;Growth;Health;Healthcare;Heme;Hospitals;Human;Hypoxia;in vivo;Infection;Infective endocarditis;inhibitor;insight;Integral Membrane Protein;Knock-out;Length;Ligand Binding;Ligand Binding Domain;Ligands;Lipids;Membrane;Metabolism;Methicillin Resistance;methicillin resistant Staphylococcus aureus;Microbial Biofilms;Modeling;Molecular;Molecular Conformation;Morbidity - disease rate;mortality;mouse model;N-terminal;nanodisk;nanoscale;Nitric Oxide;nitrosative stress;novel therapeutic intervention;novel therapeutics;OmpR protein;Osteomyelitis;Output;Oxidation-Reduction;Oxidative Stress;Oxygen;Pathogenicity;Phosphorylation;Phosphotransferases;Physiology;Pneumonia;protein-histidine kinase;Publishing;reconstitution;Regulation;Regulon;respiratory;response;Role;sensor histidine kinase;Sepsis;Signal Pathway;Signal Transduction;Site;Site-Directed Mutagenesis;small molecule;small molecule libraries;Societies;Staphylococcal Infections;Staphylococcus aureus;Staphylococcus aureus infection;Stimulus;System;Systemic infection;Testing;transmission process;treatment strategy;Variant;Virulence;Virulence Factors;Vitamin K 2;X-Ray Crystallography

PROJECT_TITLE: Molecular Mechanisms Regulating Bacterial Two-component Signaling Systems

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: IRVINE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: Project Narrative  Chlamydia is a major cause of sexually transmitted infections in the U.S., and more cases of chlamydial genital infections are reported to the CDC than any other infectious disease. This project will develop a novel protein knockdown method in C. trachomatis that is based on the use of a reprogrammed small RNA to selectively deplete levels of a target protein. This method will provide a new genetic tool for studying the function of chlamydial proteins.

PI_NAMEs: SUETTERLIN, CHRISTINE ;TAN, MING  (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Affect;Bacteria;Bacterial Genome;Biochemical;Cells;Chlamydia;Chlamydia trachomatis;Collaborations;Communicable Diseases;Country;CRISPR interference;Data;Dependence;Development;Disease Notification;Engineering;Escherichia coli;Essential Genes;Evolution;experimental study;Gene Expression Regulation;gene function;Genes;Genetic;genetic approach;genital infection;Genome;Grant;Human;human pathogen;Immunofluorescence Immunologic;Individual;Infection;inhibitor;innovation;knock-down;Membrane Proteins;Messenger RNA;Methods;Microscopy;Molecular Chaperones;novel;Operon;overexpression;Paper;pathogen;Phenotype;Physicians;Proteins;Publications;Publishing;Reporting;Research;RNA;RNA I;Role;Scientist;Sexually Transmitted Diseases;Small RNA;Specificity;Testing;tool

PROJECT_TITLE: Development of a novel protein depletion method in Chlamydia

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Autoimmune Disease;Genetics;Infectious Diseases;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative Our immune system’s ability to differentiate self from non-self nucleic acids is critical for combating pathogens and cancer. The goal of this project is to better understand the mechanisms cells use to detect foreign nucleic acids with sensitivity while avoiding aberrant activation by self molecules. The results may change our understanding of autoimmunity and cancer and provide new knowledge helpful for treating these debilitating medical conditions.

PI_NAMEs: RICE, CHARLES M (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Address;Adenosine;Apoptotic;Autoimmune Diseases;Autoimmunity;autoinflammatory diseases;base;Binding;Biological Process;Biology;Bite;Calibration;cancer cell;cancer immunotherapy;cancer therapy;Cell Death;Cell Death Induction;Cell Differentiation process;Cell Line;Cell Survival;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Co-Immunoprecipitations;crosslinking and immunoprecipitation sequencing;Double-Stranded RNA;dsRNA adenosine deaminase;Enzymes;Face;Foundations;Future;Gene Expression;Genes;Genetic Transcription;Genome;genome-wide;Goals;Grant;Human;human pluripotent stem cell;IFIH1;Immune response;Immune system;Infection;Innate Immune Response;Inosine;insight;Interferon Type I;Interferons;Introns;Investigation;knock-down;Knock-out;Knowledge;Libraries;Link;Malignant Neoplasms;Medical;Messenger RNA;Modeling;Modification;Molecular;Mutation;Names;neoplastic cell;novel;Nucleic Acids;pathogen;Pathway interactions;Pattern;Pattern recognition receptor;Predisposition;prevent;Production;promoter;Protein Family;protein kinase R;Proteins;pseudotoxoplasmosis syndrome;receptor;reconstitution;Reporting;Research;response;Retroelements;RNA;RNA Editing;RNA-Binding Proteins;Role;Small Interfering RNA;Structure;Testing;Tissues;Transcript;Translational Repression;Untranslated Regions;Untranslated RNA;Up-Regulation;Viral;viral RNA;Virus;Work

PROJECT_TITLE: Elucidating the mechanism by which ADAR1 prevents autoimmunity against self RNA

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Autoimmune Disease;Celiac Disease;Digestive Diseases;Food Allergies;Microbiome;Nutrition;Prevention

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Celiac disease is an important health problem mediated by ingestion of gluten antigens found in wheat, barley, and rye, has an estimated prevalence of 1% in the general US population and results in excessive health care costs. In this study we deploy non-pathogenic gut protists as a tool to boost oral tolerance to gluten, thereby suppressing adverse inflammatory responses to gluten that result in the development of celiac disease. This novel concept will have a positive impact on human health because it is probable that the identified protist- immune regulatory mechanisms will provide new protist-based therapeutic interventions to prevent and revert immune-mediated food sensitivities that include celiac disease and food allergies and has the potential to impact broadly on biomedical research and gut health.

PI_NAMEs: HINTERLEITNER, REINHARD  (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Affect;Alleles;Antigen Presentation;Antigens;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Autoimmune Diseases;Barley;Biomedical Research;Celiac Disease;Cell Culture Techniques;Cells;Cellular biology;cohort;Data;Dendritic Cells;design;Development;Diet;dietary;disability;Disease;disease model;effective therapy;Effector Cell;enteric virus infection;Environmental Risk Factor;Epidemiology;Food;Food Hypersensitivity;General Population;Genetic;Genetic Transcription;Gluten;Gluten-free diet;Gnotobiotic;Goals;gut health;gut microbes;gut microbiota;Health;Health Care Costs;High Prevalence;HLA Antigens;Homeostasis;Human;Immune;Immune response;Immunity;Immunologics;Immunology;immunoregulation;Impairment;In Vitro;Individual;Indoles;Inflammatory;Inflammatory Response;Ingestion;innovation;insight;Interleukin-15;Intestines;Knowledge;Lead;Learning;Malignant Neoplasms;Mediating;Metabolism;Microbe;microbiota;mouse model;Mucosal Immune Responses;Mucosal Immunity;Mus;next generation sequencing;Norovirus;novel;novel strategies;novel therapeutic intervention;novel therapeutics;oral tolerance;overexpression;Pathogenesis;Pathologic;Patients;Persons;Play;Population;pre-clinical;Predisposition;Prevalence;prevent;Prevention;Probability;programs;protective effect;Receptor Signaling;Regulatory T-Lymphocyte;Reovirus;Research;response;Risk;Role;Rye cereal;Sampling;standard of care;stem;stool sample;T-Lymphocyte;Testing;Therapeutic Intervention;Time;tool;Tritrichomonas;Tryptophan;Villous Atrophy;Virus;Wheat

PROJECT_TITLE: Role of gut protists in celiac disease

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Biotechnology;Gene Therapy;Genetics;Infectious Diseases;Lung;Nanotechnology;Pneumonia;Pneumonia and Influenza;Regenerative Medicine

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Bacterial pneumonia causes severe inflammation of the lungs that can result in organ failure and even death if left unchecked. This proposal utilizes a cutting-edge genetic engineering approach to develop a biomimetic nanocarrier that can specifically deliver anti-inflammatory steroids to inflamed infection sites. If successful, the project will help to establish a new paradigm for addressing pathological inflammation that can be applied across a wide range of diseases.

PI_NAMEs: FANG, RONNIE H (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Address;Adrenal Cortex Hormones;Adverse effects;Air Sacs;Anti-Inflammatory Agents;Antibiotic Therapy;Antibiotics;Artificial nanoparticles;Attenuated;Bacteria;Bacterial Counts;Bacterial Pneumonia;Binding;Biochemistry;Biodistribution;Biomimetics;Blood Cell Count;Blood Circulation;Cell Adhesion Molecules;Cell membrane;cell type;Cells;cellular engineering;Cellular Membrane;cellular targeting;Cessation of life;Clinical;Communities;cytokine;Data;Dendritic Cells;Disease;dosage;Drug Delivery Systems;drug resistant bacteria;effective therapy;efficacy evaluation;Endothelial Cells;Endotoxins;Engineering;fabrication;Formulation;Genetic Engineering;Goals;Gram-Positive Bacteria;Histology;Hospitals;human disease;Immune;immune activation;Immune system;Immunologic Adjuvants;Immunosuppressive Agents;improved;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;Integrin alpha4beta1;interest;intravenous administration;intravenous injection;Left;Ligands;Liquid substance;Lung;Lung infections;Membrane;methicillin resistant Staphylococcus aureus;Methods;Modeling;Molecular;Morbidity - disease rate;Morphology;mortality;mouse model;Mus;nanocarrier;Nanodelivery;nanoformulation;nanoparticle;nanoparticulate;Nanotechnology;Nature;next generation;Organ;Organ failure;P-selectin ligand protein;pathogen;Pathologic;Pathology;Patients;Pattern;Performance;Pharmaceutical Preparations;Play;prevent;Production;protein expression;Proteins;Pseudomonas aeruginosa;Pulmonary Inflammation;response;Role;Safety;Serum;side effect;Site;Source;standard of care;Steroids;Streptococcus pyogenes;Surface;targeted delivery;Therapeutic Index;Time;Treatment Efficacy;Treatment Side Effects;Vascular Cell Adhesion Molecule-1;zeta potential

PROJECT_TITLE: Inflammation-targeted delivery of corticosteroids using genetically engineered cellular nanoparticles

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Genetics;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Pediatric;Pediatric - AIDS

ORG_CITY: BOSTON

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: HIV-infected children who initiate ART in the first week of life may have both low viral reservoir and limited  viral diversity, and are therefore an ideal population to evaluate strategies other than ART for maintaining  viral suppression. This study will determine whether the broadly neutralizing antibodies VRC01LS and 10- 1074 can maintain viral suppression in early-treated children for a period of 24 weeks off ART, and will  characterize changes in viral reservoir and immune responses during and after the intervention.

PI_NAMEs: KURITZKES, DANIEL R.;LICHTERFELD, MATHIAS ;SHAPIRO, ROGER L (contact)

PROGRAM_OFFICER_NAME: CLELAND, NAANA G

PROJECT_TERMS: adaptive immune response;Adult;Aftercare;Anti-Retroviral Agents;anti-viral efficacy;Antibody Therapy;antiviral drug development;Archives;Autologous;Binding;Biological Assay;Birth;Blood specimen;Botswana;CD4 Lymphocyte Count;CD4 Positive T Lymphocytes;Cells;Characteristics;Child;Chromosomes;Clinical;Clinical Data;Clinical Markers;Clinical Research;Clinical Trials;cohort;Complex;Coupled;COVID-19;Data;design;DNA;Dose;Drug Kinetics;efficacy evaluation;Enrollment;Evaluation;Evolution;exhaustion;experience;Failure;follow-up;Frequencies;Gene Expression;Growth;HIV;HIV Genome;HIV-1;Homeostasis;Hour;Immune;immune activation;Immune response;Immune system;Immunologic Markers;Immunologics;Immunotherapy;Infant;Infection;Innate Immune Response;Interruption;Intervention;Intervention Studies;intrapartum;Kinetics;Length;Life;Longterm Follow-up;Maintenance;Measurement;Monitor;Monoclonal Antibody Therapy;Multi-Institutional Clinical Trial;neutralizing antibody;neutralizing monoclonal antibodies;novel;open label;Outcome;Participant;pediatric patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Phase;Phenotype;Plasma;Population;primary endpoint;recruit;research clinical testing;Research Infrastructure;Residual state;RNA;Safety;secondary endpoint;Serious Adverse Event;Severities;Site;small molecule;success;T-Lymphocyte;Testing;Time;timeline;transcriptome sequencing;treatment effect;Variant;Viral;viral rebound;Viral reservoir;Virus;Withdrawal

PROJECT_TITLE: A clinical trial to evaluate the impact of broadly neutralizing antibody VRC01 on HIV viral reservoir and maintenance of suppression in a cohort of early-treated children in Botswana

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Disability Research;Neurosciences;Physical Activity;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: Chicago

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Individuals with stroke often have chronic walking impairments that limit physical activity, quality of life, and community involvement and lead to increased healthcare burden and the development of secondary disabilities. The proposed work seeks to understand whether neural pathways from the non-lesioned side of the brain have enhanced use and contribute to the recovery of walking after stroke. Results from this work will provide insight into the role of novel neural pathways and may lead to a paradigm shift in lower limb rehabilitative strategy after stroke that reduces chronic walking impairment and healthcare burden.

PI_NAMEs: MADHAVAN, SANGEETHA  (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Address;Affect;Ankle;Area;Bilateral;blood oxygen level dependent;Brain;brain pathway;Cerebral hemisphere;Chronic;chronic stroke;community involvement;Corticospinal Tracts;Data;Development;Diffusion Magnetic Resonance Imaging;dimension reduction;Dimensions;disability;Fiber;Functional Magnetic Resonance Imaging;Gait abnormality;gait rehabilitation;Goals;Health Care Costs;healthcare burden;imaging study;Impairment;improved;Individual;innovation;insight;Ipsilateral;Knowledge;Lesion;Limb structure;Lower Extremity;Measurement;Measures;Methodology;Modeling;Motor;motor control;Motor Pathways;Movement;Neural Pathways;neuroregulation;novel;Paresis;Participant;Pathway interactions;Performance;Phase;Physical activity;post stroke;Quality of life;Recovery;Rehabilitation therapy;Reporting;Research;response;reticulospinal tract;Role;Severities;Side;societal costs;Stroke;stroke recovery;stroke rehabilitation;Testing;tool;Transcranial magnetic stimulation;Walking;walking rehabilitation;walking speed;Work

PROJECT_TITLE: Elucidating the role of the contralesional corticoreticulospinal tract for lower limb function after stroke.

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: STANFORD

ORG_DEPT: GENETICS

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Nicotinamide N-methyltransferase (NNMT) is a likely master regulator of triple-negative breast cancer (TNBC) gene expression through its hypomethylating effect on DNA, histones and mRNA; however, a link between NNMT expression and mRNA hypomethylation has not previously been established as a mechanism contributing to cancer progression. In my dissertation project, I am testing the hypothesis that NNMT activity in TNBC cells results in 1) reduced m6A mRNA modification associated with altered protein expression of pathways mediating cellular stress response and 2) cancer stem cell-like traits associated with survival, metastatic potential and increased in vivo tumor-forming capacity. As accumulating research has been highlighting the biological relevance of RNA modifications both in terms of normal physiology and pathology including cancer, I plan to pursue my post-doctoral research on the biological and cancer-associated role of epitranscriptomic gene expression regulation with a translational focus as an endpoint to develop novel modulators of RNA modifications as potential cancer therapeutic agents.

PI_NAMEs: DOLCEN, DENIZ NESLI (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Binding Proteins;Biological;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Model;Cancer Biology;cancer cell;cancer gene expression;Cancer Model;cancer stem cell;cancer therapy;Cell Culture Techniques;Cell Death;Cell Survival;Cells;Cellular Stress;ChIP-seq;Consumption;Data;Development;differential expression;DNA;DNA Modification Process;Epigenetic Process;epitranscriptomics;Eukaryota;Excretory function;Exhibits;Exposure to;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic regulatory protein;Genetic Transcription;histone modification;Histones;Human;Hypoxia;In Vitro;in vivo;Individual;knock-down;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Mass Spectrum Analysis;MDA MB 231;Mediating;Messenger RNA;Methylation;methylome;Methyltransferase;Modeling;Modernization;Modification;mouse model;Mus;Neoplasm Metastasis;Niacinamide;Nicotinamide N-Methyltransferase;novel;nutrient deprivation;Oncogenic;Pathology;Pathway interactions;patient derived xenograft model;Patients;pharmacologic;Phenotype;Physiology;Play;Polymerase;Postdoctoral Fellow;posttranscriptional;prevent;Process;protein expression;Proteome;Rattus;Regulator Genes;Relapse;Research;Research Project Grants;response;RNA;RNA methylation;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;single-cell RNA sequencing;Small Interfering RNA;Sprague-Dawley Rats;stemness;Stimulus;stressor;Systemic Therapy;Testing;Therapeutic Agents;trait;Transcript;Translational Regulation;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor microenvironment;tumor progression;Urine

PROJECT_TITLE: Biological and cancer-associated role of epitranscriptomic gene expression regulation


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Genetics

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: The project will develop computational tools to mechanistically capture phenotypic cell states within cell populations. These techniques will uncover drug-tolerant states in bacterial, fungal, and cancer cells leading to translational approaches to perturb states for therapeutic benefit.

PI_NAMEs: SINGH, ABHYUDAI  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Affect;Automobile Driving;Benchmarking;Biochemical;Biochemical Process;Biochemical Reaction;Biological Assay;Biological Process;cancer cell;cell killing;Cell Proliferation;cell type;Cells;computerized tools;Coupled;Data;Data Set;DNA;DNA Sequence Alteration;Drug Tolerance;drug-sensitive;environmental change;Epigenetic Process;experimental study;gene product;Heterogeneity;Human;in silico;Individual;innovation;mathematical model;Mathematics;Measurement;Measures;Messenger RNA;Methods;Microbe;Modeling;Mutation;Nature;Nobel Prize;Noise;Phenotype;Play;Population;Predisposition;Proteins;response;Role;stem cells;Techniques;Testing;Therapeutic;Time;tool;transcriptome sequencing;translational approach;Variant;Viral;Work

PROJECT_TITLE: Generalized fluctuation test for deciphering phenotypic switching within cell populations

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Pediatric

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: Project Narrative Understanding ADHD – a neurodevelopmental disorder characterized by impulsivity, hyperactivity, and exceptional difficulty with paying attention – is critical to help the increasing number of children diagnosed with ADHD each year as well as the sixty percent of diagnosed children who retain symptoms into adulthood. We aim to study one aspect of ADHD – cognitive control – using a brain activity monitoring with electroencephalography (EEG). This work will help us develop quantitative, objective ADHD diagnostics and better understand the brain science of attention.

PI_NAMEs: KWASA, JASMINE  (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Active Listening;Adult;Anxiety;Attention;Attention deficit hyperactivity disorder;Auditory;Behavior assessment;Behavioral;Biological Markers;Boston;Brain;BRAIN initiative;case control;Case/Control Studies;Cephalic;Child;Clinic;Clinical;Cognition;Cognitive;cognitive control;Cognitive deficits;cognitive neuroscience;college;Crying;Data;Data Analyses;density;Development;Diagnosis;Diagnostic;Disease;Doctor of Philosophy;Educational process of instructing;Electroencephalography;Engineering;Equilibrium;executive function;Experimental Designs;falls;Fellowship;Foundations;Frequencies;frontier;Functional disorder;functional near infrared spectroscopy;Future;General Population;Heterogeneity;Human;Hyperactivity;Impulsivity;Individual;Individual Differences;insight;interest;International;Laboratories;Language;Maps;Measures;Mental Health;Mentors;Methods;Modality;Monitor;Movement;National Institute of Mental Health;Neocortex;neural;neural correlate;Neurodevelopmental Disorder;neuroimaging;Neurologic;neuromechanism;Neuropsychological Tests;Neurosciences;novel;Oral;Participant;Pattern;Perception;Performance;Phase;Physiology;Population;Population Heterogeneity;portability;Positioning Attribute;Postdoctoral Fellow;posters;pre-doctoral;Psychopathology;Psychophysics;Race;Research;Research Domain Criteria;Research Personnel;Resolution;response;Rest;Retina;Scalp structure;Science;selective attention;Sensory;sensory stimulus;Short-Term Memory;signal processing;Societies;sound;source localization;statistics;symposium;Symptoms;targeted treatment;Techniques;Technology;tool;Training;ultrasound;Universities;Visual;Work;young adult

PROJECT_TITLE: Developing Novel Neural Technologies to Investigate Top-Down Attention in Neurologically and Racially Heterogeneous Populations


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Narrative Arthropod-borne rickettsial species are a major cause of emerging febrile illnesses with significant public health and economic impacts; however, our understanding of the genetic bases for rickettsial pathogenesis, vector transmission, and protective immunity is limited. This application aims to generate kkaebi transposon mutant libraries for two model organisms of pathogenic Rickettsia species belonging to the spotted fever and typhus groups, enabling investigators to identify essential genes for Rickettsia. Further, this application will characterize virulence genes and their biological functions, specifically focusing on those genes involved in O- antigen biosynthesis.

PI_NAMEs: KIM, HWAN KEUN  (contact)

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: Actins;Address;Anabolism;Antibiotic Therapy;Arthropod Vectors;arthropod-borne;Arthropods;base;Biochemical;Bioinformatics;Biological;Biological Assay;Biological Process;Blood;Blood Circulation;Blood Vessels;Cell Line;cell type;Cells;Chloramphenicol;Chromosomal Insertion;Clinical;Communities;comparative;Complex;Dedications;Defect;diagnostic assay;Disease;DNA sequencing;economic impact;Embryo;Endothelial Cells;Escherichia coli;Essential Genes;Evolution;FDA approved;feeding;Fever;flea-borne;Fleas;Gastrointestinal tract structure;gene conservation;Genes;Genetic;genetic manipulation;Genome;genome sequencing;Geographic Locations;Healthcare;Immune;Immune Evasion;Immunity;In Vitro;Infection;Insertional Mutagenesis;Invaded;Investigation;Laboratories;Lesion;Libraries;Lice;Life Cycle Stages;Macrophage;Mites;model organism;Modeling;Modification;Molecular Analysis;Motility;Mus;Mutagenesis;mutant;Mutation;Myalgia;Nature;O Antigens;Operon;Organism;pathogen;Pathogenesis;Pathogenicity;Pathology;Patients;Peripheral Blood Mononuclear Cell;Phase;Phenotype;Polysaccharides;Protein Biosynthesis;Proteins;Protocols documentation;Public Health;Publishing;Reaction;Research;Research Personnel;Resources;Rickettsia;Rickettsia conorii;Rickettsia Infections;Rickettsia typhi;Risk;Role;Salivary Glands;Site;Sociology;spotted fever;Symptoms;tick feeding;tick-borne;Ticks;tissue culture;tissue/cell culture;Tn5 transposase;tool;transmission process;Typhus;Vaccines;Variant;Vascular Endothelial Cell;vector;vector transmission;Vero Cells;Virulence;virulence gene;whole genome;Work

PROJECT_TITLE: Transposon mutagenesis of Rickettsia for studying Rickettsia-host-vector interactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 FDS-M (S1)]


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE Although neurotrophins, such as brain-derived neurotrophic factor (BDNF), play an essential role in neural circuit development and function, little is known about how neurotrophin-regulated transcription influences experience- dependent plasticity in the brain. This study seeks to characterize the genomic mechanisms by which BDNF regulates the maturation of inhibition within the mouse visual cortex. By identifying specific transcription factors and target genes that mediate the genomic response to BDNF in the brain, this proposal will provide novel insights into the etiology of neurological disorders that display a loss of BDNF production, including Alzheimer’s and Huntingtin’s disease.

PI_NAMEs: GEGENHUBER, JORDAN BRUNO (contact)

PROJECT_TERMS: Alzheimer's Disease;Binding;Binding Sites;Brain;Brain-Derived Neurotrophic Factor;Cell surface;cell type;Cells;Cleavage Under Targets and Release Using Nuclease;Complex;Coupling;CRISPR/Cas technology;critical period;Cyclic AMP-Responsive DNA-Binding Protein;Data;Development;Disease;DNA Double Strand Break;DNA Repair;Double Strand Break Repair;Enhancers;Etiology;excitatory neuron;experience;experimental study;Family;Family member;Gene Expression;Gene Expression Regulation;gene induction;Genes;Genetic Transcription;Genomics;Growth;histone acetyltransferase;HTATIP gene;Huntington gene;Immediate-Early Genes;Immunoprecipitation;improved;In Vitro;information processing;Inhibitory Synapse;insight;Laboratories;Life Experience;Light;Maintenance;Mass Spectrum Analysis;Measures;Mediating;Mediator;member;Methods;Modification;Molecular Target;Mus;Mutation;Nervous System Disorder;neural circuit;Neurobiology;neuronal cell body;Neurons;neurotrophic factor;Neurotrophic Tyrosine Kinase Receptor Type 2;novel;NPAS4 gene;Ocular Dominance;Phosphorylation;Play;Process;Production;programs;promoter;recruit;Regulatory Element;repaired;Resolution;response;Response Elements;Role;Sensory;Shapes;Signal Pathway;Signal Transduction;Stimulus;Synapses;Synaptic plasticity;Testing;transcription factor;Transcription-Coupled Repair;Transcriptional Activation;Transcriptional Regulation;Transgenic Mice;Visual Cortex

PROJECT_TITLE: Genomic mechanisms of BDNF signaling in the brain

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-4 Study Section [NST-4]


NIH_SPENDING_CATS: Aging;Cancer

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Project Narrative The Memorial Sloan Kettering Cancer Center Summer Research Fellowship Program is a ten-week research- training program developed for medical students hailing from diverse backgrounds. It is intended to encourage student interest in careers in biomedical research and oncology. The program encompasses laboratory-based research, didactic learning, and clinical exposure and program’s participants include a large proportion of students from minority groups that are underrepresented in the oncology workforce.

PI_NAMEs: ARIYAN, CHARLOTTE EIELSON (contact)

PROGRAM_OFFICER_NAME: ZAHIR, NASTARAN

PROJECT_TERMS: Academic Medical Centers;Address;Age;Aging;aging population;American Society of Clinical Oncology;Basic Science;Biomedical Research;cancer care;cancer education;cancer therapy;career;Clinical;Clinical Cancer Center;clinical practice;Clinical Research;Competence;Data;design;Development;Diagnosis;Education;Educational Curriculum;ethnic diversity;experience;faculty mentor;Fellowship Program;Fostering;Generations;Grant;improved;innovation;interest;Knowledge;Laboratories;Laboratory Research;Learning;Medical Students;Medicine;Memorial Sloan-Kettering Cancer Center;Mentors;Mentorship;Minority Groups;minority student;Nursing Faculty;Oncologist;Oncology;outreach;Participant;Physicians;Prevention;programs;Qualifying;racial diversity;Reporting;Research;research and development;Research Project Grants;Research Training;Retirement;Science;Scientist;student participation;Student recruitment;Students;summer research;Training;Training Programs;Translational Research;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;United States National Institutes of Health;Work

PROJECT_TITLE: Summer research experiences for medical students supervised by faculty mentors

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: This project combines the expertise of the Cotter and Doyle laboratories to determine the first structure of the Bordetella TpsB transporter (FhaC) in complex with its cognate passenger (FhaB) and to identify novel compounds that inhibit TpsB transporters. To date structural information is limited to individual structures of FhaC and FhaB which provide limited information about how TpsB proteins secrete their passengers. TpsB transporters play key roles in the pathogenesis of important Gram-negative pathogens and TpsB inhibitors have the potential to act as both targeted and broad-spectrum anti-virulence agents.

PI_NAMEs: COTTER, PEGGY A (contact);DOYLE, MATTHEW THOMAS

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acellular Vaccines;Address;Adherence;Adhesions;airway epithelium;Antibiotic Therapy;antimicrobial;Bacteria;Binding;Biological Assay;Bordetella;Bordetella bronchiseptica;Bordetella pertussis;Bordetella Virulence Factors;Cells;Collaborations;Complex;Cryoelectron Microscopy;Cyclic Peptides;Data Analyses;design;Detergents;Development;Disease;driving force;Epithelial Cells;Escherichia coli;Eukaryotic Cell;experimental study;Family;Foundations;Future;Gram-Negative Bacteria;Health;Hemagglutinin;Human;immunoregulation;In Vitro;in vivo Model;Individual;Infant;Inflammation;Inflammatory Response;inhibitor;Institution;Investigation;Iron;Laboratories;Learning;Libraries;Mediating;Membrane;Membrane Lipids;Membrane Proteins;Messenger RNA;Methods;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;N-terminal;nanodisk;novel;pathogen;Pathogenesis;Pathogenicity;Peptides;Pertussis;Pharmaceutical Preparations;Play;prevent;Protein Secretion;Proteins;Public Health;Research Personnel;Resources;Respiratory System;Role;Specificity;Structure;System;Therapeutic;transmission process;Vaccine Therapy;Virulence;Virulence Factors;Work

PROJECT_TITLE: Uncovering the two-partner secretion mechanism and novel antimicrobials


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Heparin-induced thrombocytopenia (HIT) is a thrombotic disorder that develops when patients anti-coagulated with heparin develop anti-PF4 antibodies that stimulate platelet activation and thrombosis; however, the platelet surface molecules that recruit PF4 to the platelet surface to elicit the epitopes recognized by anti-PF4 antibodies remain unknown. This paucity of knowledge has resulted in the low accuracy of frontline diagnostic assays and ineffectual treatment options for HIT patients. This proposal aims to identify the platelet surface molecules that recruit PF4 and to correlate differences in the expression of these PF4-interactors based on age, sex, and ethnicity to better risk stratify patients and identify candidate molecules for improving the diagnosis and treatment of HIT.

PI_NAMEs: KANACK, ADAM J (contact)

PROGRAM_OFFICER_NAME: HAILU, BENYAM

PROJECT_TERMS: Age;Alpha Granule;Antibodies;Anticoagulants;Anticoagulation;Attenuated;Binding;Biological Assay;Blood Platelets;candidate identification;Characteristics;Charge;Clinical;cohort;Complex;Dangerousness;Data;Death Rate;Development;Diagnosis;Diagnostic;diagnostic assay;diagnostic strategy;Diagnostic tests;diagnostic tool;Disease;efficacy evaluation;Enzymes;Epitopes;Ethnic Origin;Exposure to;Feedback;Frequencies;Functional disorder;Glycosaminoglycans;Goals;Grant;Half-Life;Heparin;Heparin Binding;heparin-induced thrombocytopenia;Hospitalization;Human;Immunoassay;improved;In Vitro;inhibiting antibody;inhibitor;innovation;Intervention;Knowledge;Length;Mediating;Modeling;Morbidity - disease rate;mortality;mouse model;murine monoclonal antibody;Mus;neoantigens;next generation;novel;novel therapeutics;Pathogenesis;Pathogenicity;patient stratification;patient subsets;Patients;PF4 Gene;Plasma;Platelet Activating Factor;Platelet Activation;Play;polyanion;Predictive Value;Proteoglycan;recruit;research clinical testing;risk stratification;Role;Science;Serology;Serology test;Severities;Severity of illness;sex;Source;Sulfate;Surface;Testing;Therapeutic;Therapeutic Intervention;Thrombocytopenia;Thrombosis;thrombotic;thrombotic complications;Thrombus;Time;translational approach

PROJECT_TITLE: The role of proteoglycans in Heparin-induced thrombocytopenia: Implications for pathophysiology, diagnosis and treatment

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI (OA)]


NIH_SPENDING_CATS: Coronaviruses;Genetics;Lung

ORG_DEPT: PATHOLOGY

PHR: NARRATIVE Dendritic cells (DCs) play key roles in orchestrating immunity to pathogens. Multiple subsets of functionally specialized DCs exist, but DC function can also be modulated by microbial and tissue-derived stimuli. We have recently demonstrated a major role for the metabolic sensors mTOR and GCN2 in regulating DC development and function, and the underlying mechanisms of this “metabolic imprinting” will be explored.

PI_NAMEs: PULENDRAN, BALI  (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Ablation;adaptive immunity;Adoptive Transfer;Allergic;Allergic inflammation;Alveolar Macrophages;Amino Acids;Autophagocytosis;Bone Marrow;Cell Communication;Cell Physiology;cell type;Cells;Cellular biology;Chimera organism;conditional knockout;Data;Dendritic Cells;Development;EIF4EBP1 gene;Epigenetic Process;Epithelial Cells;FRAP1 gene;functional plasticity;gene repression;Genetic Transcription;gut inflammation;Hematopoietic;Homeostasis;Immune response;Immunity;imprint;In Situ;Infection;Inflammasome;Inflammation;insight;ITGAM gene;ITGAX gene;Knockout Mice;lipid metabolism;Lung;Lymphoid Cell;Macrophage;Mediating;Metabolic;metabolic profile;microbial;Modeling;Molecular;monocyte;mRNA Translation;mTOR Signaling Pathway;Mus;Natural Killer Cells;Nature;neutrophil;Organ;Outcome;pathogen;Pathway interactions;Phenotype;Play;programs;pulmonary function;receptor;response;Role;sensor;Signal Pathway;Signal Transduction;single cell ATAC-seq;Spleen;Starvation;Stimulus;Stress;Tissues;transcription factor;Vaccination;Viral;Work

PROJECT_TITLE: Metabolic imprinting of dendritic cell fate and function in tissues

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(57)]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: WORCESTER

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE The CardiOvascular Digital hEalth Research (CODER) program will train postdoctoral MD and PhD scientists in digital health. CODER includes themes of informatics, data science, artificial intelligence, mobile health, point- of-care technologies, implementation science, and health equity applied to cardiovascular disease management and prevention. Ultimately, CODER trainees will make future innovative discoveries as independent investigators that will advance the field and support the mission of NHLBI.

PI_NAMEs: GERBER, BEN STEVEN;MCMANUS, DAVID D. (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Cardiovascular system;digital health;Research Training;Training Programs

PROJECT_TITLE: CardiOvascular Digital hEalth Research (CODER) Training Program

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM (OA)]


NIH_SPENDING_CATS: Asthma;Clinical Research;Dental, Oral, and Craniofacial Disease;Lung;Pain Research;Precision Medicine

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative – Public Health Relevance Statement Dr. Tanya Laidlaw is a recognized patient-oriented investigator in the study of respiratory diseases, in particular severe asthma and chronic sinus disease, which collectively afflict up to 10% of the US population and have high morbidity and few available treatments. This project aims to determine which immune pathways are important causes of these inflammatory respiratory diseases, and how new biologic drugs that treat them can work to improve patients’ respiratory health but may also cause other systemic immune consequences. Dr. Laidlaw is a very engaged research mentor, and this grant will support her ability to mentor and train the next generation of clinical scientists in patient-oriented allergic and airway disease research.

PI_NAMEs: LAIDLAW, TANYA MARIA (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Adverse drug effect;Adverse effects;Affect;Airway Disease;airway inflammation;Allergic;allergic airway disease;Allergic Disease;Anosmia;Arthralgia;Arthritis;aspirin-exacerbated respiratory disease;Asthma;Automobile Driving;Award;Biological;Biological Markers;Biological Products;biomarker identification;Biopsy;Blood;Cell Adhesion Molecules;Cell Proliferation;cell type;Cells;Chronic;Chronic Disease;chronic rhinosinusitis;Clinical;clinical efficacy;clinically relevant;Collaborations;cytokine;Data Analyses;Data Set;Development;Diagnosis;Disease;Down-Regulation;Effector Cell;Environment;eosinophil;Epithelial Cells;Epithelium;experimental study;FDA approved;Functional disorder;Funding;Gene Expression;Goals;Grant;Human Biology;Hypersensitivity;IL17 gene;Immune;Immune response;Immunologics;Impairment;improved;Inflammation;Inflammatory;innovation;Institution;interest;Interleukin-13;Interleukin-4;Interleukin-5;Leadership;Link;Liquid substance;Longitudinal Studies;mast cell;Mediating;Mediator;Mentors;Mentorship;Molecular;Morbidity - disease rate;Mucous Membrane;multidimensional data;Multiomic Data;multiple omics;Nasal Epithelium;Nasal Polyps;next generation;Nose;novel marker;Outcome;Pathway interactions;patient oriented;patient oriented research;patient subsets;Patients;Pharmaceutical Preparations;Plasma Cells;Play;polyposis;Population;predictive marker;Production;Prospective Studies;Proteomics;public health relevance;receptor;Research;Research Personnel;Research Project Grants;Resources;respiratory;Respiratory Disease;respiratory health;Respiratory Signs and Symptoms;Respiratory System;Role;Scientist;side effect;Signal Transduction;single-cell RNA sequencing;Sinus;skills;T-Lymphocyte Subsets;Therapeutic;Time;Tissues;Training;training opportunity;treatment response;Urine;Visit;Work

PROJECT_TITLE: Patient-Oriented Research Mentorship and Training in Upper Airway Allergic and Inflammatory Diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 VSR-I (S2)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: LOUISVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: NARRATIVE This project will generate novel immunotherapeutic drug candidates against ovarian cancer based on lectikines, which are recombinant fusion proteins consisting of the tumor glycobiomarker-targeting lectin Avaren and an antitumor cytokine. We will design and produce several lectikine constructs and evaluate them in in vitro assays and in a mouse ovarian cancer model. Successful completion of this pilot project will establish an important proof-of-concept data package justifying further preclinical development of our first-in-class immunotherapeutic candidate for ovarian cancer.

PI_NAMEs: MATOBA, NOBUYUKI  (contact)

PROGRAM_OFFICER_NAME: HARRIS, RAYMOND D

PROJECT_TERMS: Abdomen;Actinobacteria class;Address;Affinity;analog;Animal Model;Animals;Anti-viral Agents;antibody-dependent cell cytotoxicity;Antineoplastic Agents;antitumor effect;antiviral immunity;Binding;Biochemical;Biological;Biological Assay;Biological Products;bioluminescence imaging;biophysical properties;Biophysics;Body Weight;C57BL/6 Mouse;cancer cell;Cancer cell line;cancer immunotherapy;Cancer Model;cancer therapy;Cause of Death;Cell Line;Cell surface;Cells;Chemoresistance;chemotherapy;Chimeric Proteins;Clinical;cytokine;Data;Data Set;design;Development;Diagnosis;Disease Progression;drug candidate;Engineering;Enzyme-Linked Immunosorbent Assay;Euthanasia;Exclusion;Exhibits;experience;experimental study;expression vector;Flow Cytometry;Foundations;Goals;High Pressure Liquid Chromatography;HIV;Human;human model;IgG1;IL2RA gene;Immune;immune activation;Immune checkpoint inhibitor;Immunocompetent;immunogenicity;Immunohistochemistry;Immunologics;Immunophenotyping;Immunotherapeutic agent;Immunotherapy;Implant;improved;In Vitro;in vitro Assay;in vivo;Infiltration;Interleukin-15;Interleukin-2;Investigation;Laboratories;Lectin;Malignant Breast Neoplasm;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;Mannose;manufacture;Measurement;Melanoma;Modeling;Molecular;Monitor;monocyte;Mus;neoplastic cell;Nicotiana;Non-Small-Cell Lung Carcinoma;Normal Cell;Normal tissue morphology;novel;novel strategies;Operative Surgical Procedures;ovarian neoplasm;Ovary;overexpression;Patients;Peritoneal;Peritoneal lavage;Pilot Projects;Plant Viruses;Plants;Polysaccharides;preclinical development;Primary Neoplasm;Property;Protein Engineering;Proteins;Recombinant Fusion Proteins;Recombinant Proteins;recruit;Recurrent disease;Series;Site;Skin Cancer;Spleen;Surface;Surface Plasmon Resonance;Survival Rate;System;T cell infiltration;targeted agent;Therapeutic Effect;therapeutic evaluation;Tissues;Toxic effect;tumor;Tumor Debulking;tumor growth;tumor microenvironment;tumor-immune system interactions;United States;Variant;Viral;Viral Physiology;Virus;Western Blotting;Xenograft Model

PROJECT_TITLE: Lectikines for Immunotherapy against Ovarian Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-S (O1)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Hearing Loss;Neurosciences;Prevention;Rehabilitation

ORG_CITY: MOUNT PLEASANT

ORG_NAME: CENTRAL MICHIGAN UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE The size and shape of the external-ear structures (e.g. pinna, concha, ear canal) amplify and attenuate certain frequencies, which affects the way individuals naturally hear sound - each with a slightly different spectral profile. Unfortunately, the majority of audiologists automatically program hearing aids using an average amount of external-ear amplification (up to 20 dB of error) rather than directly measuring the patient’s unique external ear amplification, which results in under-amplification (poor audibility) or over-amplification (noise-induced hearing loss). In this project, we will test the hypothesis that average estimates of external-ear amplification will improve if they are normed using body height, pinna size, and ear canal size, instead of body age.

PI_NAMEs: GRINN, SARAH  (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Academy;Acceleration;Adolescent;Adopted;Adult;Affect;Age;age group;American;Anatomy;Appointment;Attenuated;attenuation;Audiology;Body Height;Body Size;Child;Childhood;Chronology;Clinical;Clinical Skills;clinically relevant;Cochlea;cohort;Concha;Cost Measures;Coupled;Data;design;Development;Ear;Ensure;Equipment;Error Sources;Exhibits;External auditory canal;External Ear;external ear auricle;First Aid;Frequencies;Hearing;Hearing Aids;hearing impairment;hearing measurement;Hearing Tests;Height;Human body;improved;Individual;individual patient;Injury;Labyrinth;life span;longitudinal design;Mainstreaming;Measurement;Measures;Methods;microphone;Modeling;Noise;Noise-Induced Hearing Loss;Organ;Output;Participant;patient safety;Patients;Perforation;Practice Guidelines;pressure;Procedures;programs;Protocols documentation;Proxy;Safety;Severities;Shapes;sound;Speech;Structure;Surveys;Testing;Time;tool;Tympanic membrane;Update

PROJECT_TITLE: Improving Automated Hearing Aid Safety and Audibility; External-Ear Amplification Predictions Based on Height, Not Age

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: 8. Project Narrative Training a new generation of investigators to understand how behavioral and environmental risk factors impact cardiovascular and metabolic diseases, and how to cost-effectively and sustainably modify these factors, is among the most important scientific tasks of our time. These are global challenges, as changing behaviors and environmental risks are rapidly increasing cardiovascular and metabolic diseases worldwide and widespread use of costly new drug- and device-related treatments may not be practical or cost-effective.

PI_NAMEs: DANAEI, GOODARZ ;RIMM, ERIC B (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TITLE: CVD Epidemiology Training Program in Behavior, the Environment and Global Health


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Orphan Drug;Precision Medicine;Racial and Ethnic Minority Health Research;Rare Diseases;Uterine Cancer;Vaginal Cancer;Women's Health Research

ORG_CITY: Columbus

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Dr. Floor Backes is exceptionally passionate about improving outcomes of all patients through participation in clinical trials with equal access to care and research. This award would support Dr. Backes to work within NRG Oncology continue to design, develop, and support novel paradigm shifting clinical trials as principle investigator, mentor, Co-Chair of the NRG Oncology Developmental Therapeutics (DT) committee, member of the Uterine Corpus Committee, and NCI Uterine Taskforce. Local institutional goals are to support the Ohio State University and James Comprehensive Cancer Center to develop a comprehensive system for multidisciplinary collaboration and molecular matching increase enrollment to NCTN trials and especially to disease agnostic molecular driven trials, streamline trial implementation and to increase the referral and accrual of racial/ethnic minorities to NCI’s National Clinical Trials Network (NCTN) prevention/control and treatment trials.

PI_NAMEs: BACKES, FLOOR J. (contact)

PROGRAM_OFFICER_NAME: MAHER, MOLLY ELIZABETH

PROJECT_TERMS: Advisory Committees;Affect;Area;Award;Awareness;black women;Body of uterus;Brachytherapy;cancer care;Cancer Patient;cancer site;clinical trial enrollment;Clinical Trials;Collaborations;Comprehensive Cancer Center;control trial;design;Development;Developmental Therapeutics Program;Disease;Doctor of Philosophy;Endometrial Carcinoma;Enrollment;Epidemiology;ethnic minority;Exposure to;Failure;Fellowship;Floor;Funding;Goals;Gynecologic Oncology;Health Services Accessibility;high risk;Immunotherapy;Improve Access;improved;improved outcome;Incidence;ineffective therapies;Institution;Interdisciplinary Study;Malignant Female Reproductive System Neoplasm;Malignant Neoplasms;member;Mentors;Minority;Mismatch Repair Deficiency;Molecular;Molecular Profiling;molecular subtypes;mortality;Mutation;National Clinical Trials Network;novel;Ohio;Oncology;Patient-Focused Outcomes;Patients;personalized medicine;Population;Prevention trial;Process;racial minority;rare cancer;Research;Research Personnel;Resources;Risk;Role;Site;System;targeted treatment;Therapeutics Committee;Time;Toxic effect;treatment trial;Underrepresented Populations;Universities;Uterine Cancer;Uterus;Vagina;Work

PROJECT_TITLE: Gynecologic cancer care: Improving clinical trial enrollment through molecular matching with targeted therapies and improving equal access to care and research for all populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-1 (O1)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Alzheimer’s disease and related dementias (ADRD) are a major and growing public health concern, but their life course social determinants have been difficult to study because most studies lack data on the full life span. This project will build a synthetic cohort from three component datasets that, together, cover the full life course to investigate the life course impact of financial wellbeing on later cognitive decline, ADRD risk, and disparities in these outcomes. In addition, we will examine whether accelerated biological aging acts as a mechanism through which these relationships operate and identify hypothetical age-specific interventions on financial wellbeing that could reduce ADRD burden and disparities.

PI_NAMEs: KEZIOS, KATRINA L (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Address;Adolescent;Adult;age acceleration;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Area;Arteries;Biological Aging;Biosocial;Black American;black women;career;Cognition;Cognitive;Cognitive aging;cognitive neuroscience;cohort;Cohort Studies;Coronary Artery Risk Development in Young Adults Study;Data;data fusion;Data Set;dementia burden;dementia risk;Development;Disparity;Disparity population;epigenetic clock;Ethnic Origin;Exclusion;experience;Exposure to;Face;Financial Hardship;follow-up;Foundations;Frequencies;Gender;Health;Health and Retirement Study;high risk;Impaired cognition;improved;Individual;Inequality;Inequity;innovation;Intervention;Life;Life course epidemiology;Life Cycle Stages;life span;Longitudinal Studies;Measurement;Measures;Mediating;Mental Health;Mentorship;Methods;Minority Groups;National Longitudinal Survey of Adolescent to Adult Health;Neurosciences;Outcome;Pathway interactions;Personal Satisfaction;Persons;physical conditioning;Process;programs;Public Health;Race;racial disparity;Reporting;Research;Research Activity;Research Personnel;Risk;Selection Bias;sex;social;social determinants;Social Policies;socioeconomics;Source;Stress;stressor;Techniques;theories;Training;Training Activity;United States;Walking;Woman;Work;young adult

PROJECT_TITLE: Investigating financial wellbeing, biological aging, and risk of Alzheimers disease and related dementias in a life course synthetic cohort

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


ADMINISTERING_IC: DE

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Cervical Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Infectious Diseases;Rare Diseases;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: TUCSON

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative  Human papillomavirus (HPV) causes 5% of cancers worldwide, including a growing number of oral cancers. In the United States, HPV-associated oral cancers, most often arising in the tonsils, are considered an epidemic but are poorly understood. To contribute to fundamental knowledge and address the oral health burden caused by HPV, this project will determine the host factors regulating oral HPV infection and carcinogenesis using three-dimensional epithelial models and computational approaches.

PI_NAMEs: JACKSON, ROBERT  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: 3-Dimensional;Address;Advisory Committees;Agonist;Animal Model;antagonist;Arizona;Biopsy;Cancer cell line;Cancer Etiology;Cancer Model;carcinogenesis;career development;Cell surface;cell transformation;Cells;Cisplatin;Clinical;Clinical Data;Coupled;crypt cell;Data;Dependence;Development;Development Plans;diagnostic biomarker;drug repurposing;Early Diagnosis;Ensure;Environment;Epidemic;Epithelial Cells;Epithelium;experimental study;Faculty;Fenofibrate;Genes;Genitalia;Goals;Head and Neck Cancer;Health;HPV oropharyngeal cancer;HPV positive;Human;Human papilloma virus infection;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16;human tissue;Impairment;In Vitro;Infection;Integration Host Factors;interest;keratinocyte;Knowledge;Life Cycle Stages;lipid metabolism;Malignant - descriptor;malignant mouth neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Maps;Mentors;Methods;Modeling;National Institute of Dental and Craniofacial Research;Oncogenic;Oral;oral cavity epithelium;Oral health;oral HPV infection;oral infection;oral pathogen;oral tissue;Oropharyngeal;Outcome;particle;Pathway interactions;Patients;Phase;Phenotype;Positioning Attribute;Postdoctoral Fellow;PPAR alpha;pre-clinical;Prevention;Productivity;programs;Research;research and development;Research Personnel;Research Project Grants;Role;single-cell RNA sequencing;Site;Skin;spatiotemporal;Structure;Surface;tenure track;Testing;Therapeutic;Tissue Differentiation;Tissues;Tonsil;Training;Training Technics;transcription factor;transcriptome;transcriptomics;tumor;tumor growth;tumorigenesis;tumorigenic;Tumorigenicity;United States;Universities;Viral;Virus;Work

PROJECT_TITLE: Assessing human papillomavirus type 16 transforming vs productive infections in oral epithelia

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Early-onset Alzheimer’s disease (EOAD) is a critically understudied form of AD compared with its late-onset counterpart, with little evidence regarding the mechanisms underlying disease progression. By combining longitudinal multimodal in vivo neuroimaging acquired in patients, graph theory, and brain transcriptome analysis, the current project will characterize the contributions of brain network connectivity and specific genetic factors to the spread of tau pathology. Results will help elucidate drivers of the pathological cascade in EOAD and contribute to the development of patient-specific approaches to monitor disease progression.

PI_NAMEs: KATSUMI, YUTA  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Advisory Committees;Age related comorbidities;Aggressive Clinical Course;Alzheimer's disease patient;apolipoprotein E-4;behavioral neurology;Brain;career;Clinical;clinical heterogeneity;Clinical Trials;Clinical Trials Design;Cognitive;cohort;Data;Data Set;Dementia;Development;Diagnosis;Diffusion Magnetic Resonance Imaging;Disease Progression;Early Onset Alzheimer Disease;Environment;Exclusion;experience;Fostering;Functional Magnetic Resonance Imaging;Funding;Future;Gene Expression;Gene Expression Profiling;General Hospitals;Genes;Genetic;Genetic Markers;genetic risk factor;Goals;Grant;Graph;graph theory;Growth;Heritability;imaging biomarker;imaging genetics;Impaired cognition;improved;in vivo;Individual Differences;individual patient;insight;K-Series Research Career Programs;Knowledge;Late-Onset Disorder;Link;Literature;longitudinal positron emission tomography;marginalization;Massachusetts;medical schools;Mentors;Methods;Monitor;multimodal neuroimaging;multimodality;Mutation;Network-based;Neurofibrillary Tangles;neurogenetics;neuroimaging;neuropathology;Neurosciences;novel;Outcome;Pathologic;Pathology;Pathway Analysis;Patients;Pattern;Personal Satisfaction;Population;Positron-Emission Tomography;Predisposing Factor;radiotracer;Regression Analysis;Research Personnel;Research Project Grants;Resolution;Resources;Role;Scientist;Site;skills;spatiotemporal;Specificity;System;system architecture;tau aggregation;tau Proteins;Techniques;tool;Training;trait;transcriptome;transcriptomics;unethical;United States

PROJECT_TITLE: Neurogenetic contributions to the spread of tau pathology in sporadic early-onset Alzheimer's disease

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Epilepsy;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: Newark

ORG_DEPT: NEUROSURGERY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Narrative Epilepsy, a debilitating neurological disorder characterized by unpredictable and abnormal electrical discharges and recurrent seizures, affects more than 65 million people worldwide, with one third of cases not being adequately controlled with existing therapies. In this study, we will carry out IND-enabling studies and the first-in- human clinical trials to move pluripotent stem cell-derived human cortical interneuron transplantation into clinical reality. This work will be pivotal in bringing this novel and restorative therapy to patients with epilepsy who have limited options.

PI_NAMEs: CHUNG, SANGMI  (contact)

PROGRAM_OFFICER_NAME: FRIEDMAN, LAUREN GENIENE

PROJECT_TERMS: Adult;Affect;Animals;Anticonvulsants;Behavioral;Biodistribution;Boston;Brain;Cell Therapy;Cells;Child Health;Clinic;Clinical;clinical translation;Clinical Trials;cohort;comorbidity;Cyclic GMP;Derivation procedure;Development;Devices;Dose;early phase clinical trial;effective therapy;efficacy study;efficacy testing;efficacy validation;Electroencephalography;Engraftment;Ensure;Epilepsy;Ethical Issues;Excision;Feedback;Female;fetal;first-in-human;Freezing;Generations;genome editing;Goals;Graft Survival;Growth;Health Status;hippocampal sclerosis;Hippocampus;Histologic;Histopathology;Hospitals;Human;human pluripotent stem cell;Immunosuppression;Implant;in vivo;induced pluripotent stem cell;Inflammation;Injections;Interneurons;Intervention;Intractable Epilepsy;Investigational Therapies;Kainic Acid;Laboratories;large scale production;Lead;Legal patent;male;manufacturing scale-up;Measures;Medial;Medical center;medical schools;Methods;migratory population;Modeling;Monitor;Mus;Navigation System;Nervous System Disorder;Neurons;Neurosurgeon;neurosurgery;New York;novel;novel therapeutics;Patients;Persons;Pharmaceutical Preparations;Phase;Phenotype;Pilocarpine;Play;Pluripotent Stem Cells;Positioning Attribute;postmitotic;pre-Investigational New Drug meeting;primary outcome;Procedures;Production;Proliferating;Protocols documentation;Psychologist;Quality Control;Reagent;Recurrence;Refractory;Research;Research Contracts;Resting Phase;Risk;Role;Safety;scale up;Seizures;Site;Technology;Temporal Lobe Epilepsy;Testing;Therapeutic;Toxic effect;Toxicology;Translating;Transplantation;tumor;tumorigenesis;United States National Institutes of Health;Work

PROJECT_TITLE: Cortical Interneuron Transplantation to Treat Intractable Epilepsy

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-Q (07)]


NIH_SPENDING_CATS: Cancer;Genetics;Human Genome

ORG_CITY: SAN ANTONIO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Project Narrative A steady stream of new researchers is necessary to continue the fight against cancer, the primary cause of death in the U.S. Critical to the success of training the next generation of scientists is promoting a diverse workforce; this is not only key aspect of this proposed training program but is also an inherent mission to our minority serving university. The goal of this Epigenetics, DNA repair and Genomics (EDGe) Training Program in Cancer is to train 4 PhD students per year in multidisciplinary cancer research, building on our institutional faculty's strengths in DNA repair and epigenetics – key areas that impact cancer development and treatment.

PI_NAMEs: LEACH, ROBIN JEAN;MALKOVA, ANNA L (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: DNA Repair;Epigenetic Process;Genomics;Malignant Neoplasms;Training Programs

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-R (O2)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Data Science;Drug Abuse (NIDA only);Genetics;Health Services;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Pain Research;Patient Safety;Precision Medicine;Prevention;Substance Misuse

PHR: PROJECT NARRATIVE This proposal aims to quantitatively evaluate effects of opioid drugs on post-surgical pain relief and risk of opioid-related adverse drug events using patient-level clinical and genetic information. Statistical and machine learning models will be developed to recommend optimal opioid prescription dosage (oral morphine milligram equivalents). Polygenic risk score will be built to represent patients' genetic susceptibility to the given post- surgical opioid prescription-related outcomes and identify high-risk patient populations.

PI_NAMEs: SONG, WENYU  (contact)

PROGRAM_OFFICER_NAME: GOLDSTEIN, AMY B

PROJECT_TERMS: Absence of pain sensation;Acute;addiction;Adverse drug event;All of Us Research Program;Analgesics;Applications Grants;Area;Artificial Intelligence;Award;Behavioral;big biomedical data;Big Data;biobank;Biological;Biology;career;central database;Clinical;clinical application;Clinical Data;Clinical Decision Support Systems;clinical decision-making;clinical implementation;clinical phenotype;clinical practice;Collaborations;Complex;Data;Data Analyses;data mining;Data Set;data warehouse;Databases;Decision Making;Dedications;Delirium;Diagnosis;Disease;Disparate;dosage;Dose;Drug Prescriptions;Electronic Health Record;experience;Foundations;functional genomics;Funding;Future;Gender;Genes;Genetic;genetic analysis;genetic architecture;genetic information;Genetic Markers;Genetic Predisposition to Disease;genetic variant;genome wide association study;genome-wide analysis;genomic data;Genomics;Genotype;genotyped patients;Goals;Guidelines;Healthcare Systems;high risk;Hospitals;improved;Individual;Informatics;Inpatients;Institution;Judgment;Knowledge;large scale data;Link;machine learning model;Mentored Research Scientist Development Award;Mentorship;Methodology;Methods;milligram;model development;Modeling;Morphine;multidisciplinary;multimodality;non-opioid analgesic;novel therapeutic intervention;Operative Surgical Procedures;Opiate Addiction;Opioid;Opioid Analgesics;opioid use disorder;Oral;Outcome;Pain;Pain management;pain relief;Pathway interactions;patient oriented;patient population;patient response;Patient-Focused Outcomes;Patients;Pattern;Pharmaceutical Preparations;Pharmacogenomics;Phenotype;polygenic risk score;Population;Postoperative Pain;predictive modeling;predictive tools;Predisposition;prescription opioid;Probability;programs;Race;Recommendation;Research;Research Personnel;response;Risk;risk prediction;skills;Socioeconomic Status;Source;statistical and machine learning;Sum;System;Techniques;tool;United States;United States National Institutes of Health;Validation;Ventilatory Depression;Work

PROJECT_TITLE: Linking Genetic and Clinical Data to Optimize Surgical Opioid Analgesic Prescribing and Predict Risks of Opioid-Related Adverse Drug Events

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-Z (90)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Pediatric;Suicide

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Self-inflicted injury (SII) commonly emerges in adolescence and is associated with severe psychopathology and increased suicide risk. Although we have evidence-based interventions for youth SII, biosocial mechanisms of change are underexplored and we lack vital data on how adolescents apply and retain therapeutic skills in daily life. The proposed study will directly compare the influence of two core intervention skills among self-injuring adolescents across neural, cardiovascular, and behavioral levels of functioning; and investigate skill uptake, use, and retention in daily life.

PI_NAMEs: KAUFMAN, ERIN ANNE (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Adolescence;Adolescent;Affect;Affective;Area;Behavior;Behavior assessment;Behavioral;Biosocial;Brain;Cardiac;Cardiovascular system;Cause of Death;Characteristics;Conflict (Psychology);Data;data acquisition;design;Dialectical behavior therapy;Ecological momentary assessment;Educational process of instructing;efficacious treatment;emotion dysregulation;emotion regulation;Emotions;Empathy;Etiology;Evidence based intervention;experience;Feeling suicidal;follow-up;Functional Magnetic Resonance Imaging;Genetic Crossing Over;high risk;improved;Injury;innovation;interest;Intervention;intervention effect;Interview;Laboratories;Lead;Learning;Left;Life;Life Stress;Maintenance;Measurement;Measures;Medial;Mentorship;Methods;multimodality;neural;Outcome;Outcome Measure;Parents;Participant;Persons;perspective taking;Physiological;Population;Prefrontal Cortex;primary caregiver;Process;programs;Protocols documentation;Psychiatric Diagnosis;Psychopathology;Psychophysiology;Public Health;Questionnaires;Randomized;Recording of previous events;Reporting;Research;Research Personnel;research study;respiratory;response;Risk;Sampling;Self Assessment;Severities;Sinus;skill acquisition;skills;skills training;social;Stress;stressor;suicidal risk;Suicide;suicide rate;Symptoms;Testing;Therapeutic;Time;Training;Training Programs;Translating;uptake;Visit;Vulnerable Populations;Withdrawal;Work;Youth

PROJECT_TITLE: Examining Mechanisms of Change in Adolescent Self-Inflicted Injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-P (02)]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: SEATTLE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Medication errors or adverse events are a major public health problem causing thousands of deaths annually. This proposal aims to build wearable cameras with real-time computer vision algorithms to identify medications when initially selected by an anesthesiology provider during drug preparation or before injection to potentially prevent accidentally giving the wrong drug. Drug dose will also be determined and recorded in an electronic health record, potentially increasing record accuracy and decreasing manual tasks for anesthesiologists so they can focus on direct patient care.

PI_NAMEs: MICHAELSEN, KELLY  (contact)

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TERMS: Accidents;Adverse event;Algorithms;Anesthesia procedures;Anesthesiology;Anesthetics;auditory feedback;Augmented Reality;Award;Bar Codes;Cessation of life;Classification;Clinical;Computer software;Computer Vision Systems;Computerized Medical Record;Computers;Consumption;cost;Data Set;Databases;design;detection platform;Devices;direct patient care;dosage;Dose;Drug Compounding;Drug Delivery Systems;Electronic Health Record;Elements;Emergency Situation;Engineering;Environment;Etiology;Event;experience;Eye;feasibility testing;Feedback;Future;Grant;Hand;Handwashing;Head;Health;Hospitalization;Hospitals;Human;Image;improved;Injectable;Injections;innovation;Institution;Intensive Care Units;Label;Learning Skill;Light;light weight;Machine Learning;machine learning algorithm;Manuals;Measures;Medical Errors;Medical Records;Medication Errors;Methodology;Modality;Monitor;neural network;Operating Rooms;Operative Surgical Procedures;patient safety;Patients;Performance;Persons;Pharmaceutical Preparations;prevent;Procedures;prototype;Provider;provider adherence;Public Health;Records;Reporting;Resolution;Risk;risk mitigation;Safety;Scanning;Standardization;Sterility;Syringes;System;Techniques;Technology;Time;tool;Training;United States;Vial device;Video Recording;virtual;visual feedback;wearable device;Weight;Work;Workload

PROJECT_TITLE: Intelligent wearable system for preventing medication errors in anesthesiology

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative:  Release probability (P(r)) of neurotransmitter containing vesicles is a critical component of information transfer between neurons and is dynamically regulated by a variety of molecular and circuit mechanisms. Here I combine an array of novel imaging, electrophysiological, behavioral, and pharmacological methods to interrogate the regulation of P(r) in vivo at multiple different scales. This will lead to a novel understanding of how individual pre-synaptic sites are regulated and bridge a wealth of literature in reduced preparations to the awake, behaving brain.

PI_NAMEs: PATEL, PARAS  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Acetylcholine;Action Potentials;Address;Affect;Animals;Arousal;awake;Axon;Behavior;behavior influence;Behavioral;Biochemistry;Brain;Cells;Communication;Contralateral;Coupled;Diameter;Electrophysiology (science);Environment;Event;experience;experimental study;Face;Glutamates;Goals;Image;Imaging Device;imaging modality;In Vitro;in vivo;in vivo imaging;Individual;innovation;insight;Investigation;Ipsilateral;Laboratories;Length;Literature;Location;Locomotion;Measurement;Measures;Mediating;Mentors;Methods;Mission;Molecular;Monitor;Movement;Mus;Muscarinic Acetylcholine Receptor;Muscarinic M2 Receptor;Mydriasis;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurobiology;Neuromodulator;Neurons;neuropsychiatric disorder;neuroregulation;Neurosciences;neurotransmission;Neurotransmitters;novel;Optics;pharmacologic;Physiology;Play;postsynaptic;Preparation;presynaptic;Presynaptic Terminals;Probability;Property;Pupil;receptor;Regulation;Resolution;Role;Shapes;Signal Transduction;Site;Somatosensory Cortex;spatiotemporal;Synapses;synaptic depression;synaptic function;System;Testing;tool;tool development;Training;two photon microscopy;two-photon;Variant;Vesicle;Visualization

PROJECT_TITLE: Interrogating Dynamic Regulation of Pre-Synaptic Release Probability In Vivo

STUDY_SECTION_NAME: NST-4 Study Section [NST-4]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Hematology;Human Genome;Immunotherapy;Orphan Drug;Pancreatic Cancer;Precision Medicine;Rare Diseases

ORG_NAME: BOSTON MEDICAL CENTER

PHR: Project Narrative There is an urgent need to improve the prognostic classification of patients with neuroendocrine tumors (NETs), a tumor type rapidly rising in prevalence and incidence. We propose that NET progression and aggressiveness is linked with multi-factorial alterations in patient-specific factors encoded within the tumor microenvironment (TME), such as the spatial distribution patterns and cellular interactions of the different macrophage populations that underlie the creation of an immunosuppressive milieu. If identified, understanding these spatial TME characteristics will lead to a more accurate prognosis and may provide a robust foundation for future therapeutic development of novel and holistic approaches that target NETs.

PI_NAMEs: DRIES, RUBEN ;HEAPHY, CHRISTOPHER M (contact)

PROGRAM_OFFICER_NAME: BHARTI, SANITA

PROJECT_TERMS: Accounting;Address;Adenocarcinoma;Architecture;Biological;Biology;biomarker discovery;biomarker identification;cancer cell;Cell Communication;Cell Fraction;cell type;Cells;Characteristics;chemokine;Classification;Clinical;clinical biomarkers;Clinical Management;Common Neoplasm;Complex;Coupling;cytokine;Cytokine Signaling;Cytometry;Data;Diffuse;Disease Outcome;Disease Progression;Ecosystem;Foundations;Future;Gastrointestinal Carcinoid Tumor;Gastrointestinal tract structure;gene panel;Genetic;Goals;Grouping;Heterogeneity;high dimensionality;holistic approach;Human;Image;Immune;immune cell infiltrate;Immunologics;Immunosuppression;Immunotherapy;improved;Incidence;Infiltration;innovation;innovative technologies;insight;Intestinal Neuroendocrine Neoplasm;Islet Cell Tumor;Knowledge;Link;Lymphoid;Lymphoid Cell;Macrophage;Malignant Neoplasms;Measures;Mediating;Molecular;Mutation;Myelogenous;Myeloid Cells;Natural History;Neoplasms;Neuroendocrine Cell;Neuroendocrine Tumors;new therapeutic target;novel;novel marker;novel strategies;outcome prediction;Pancreas;pancreatic neoplasm;Pathologic;Pathway interactions;Patients;Pattern;Population;Prevalence;Process;Prognosis;prognostic;prognostic indicator;Prognostic Marker;programmed cell death ligand 1;programmed cell death protein 1;Proteins;Resolution;response;Retrospective cohort;Role;Signal Transduction;single-cell RNA sequencing;Small Intestines;Spatial Distribution;specific biomarkers;Stratification;Structure;System;Systemic Therapy;targeted treatment;Technology;Testing;Therapeutic;therapeutic development;therapeutic target;Tissues;transcriptomic profiling;transcriptomics;treatment response;tumor;Tumor Biology;tumor microenvironment;tumor progression;Tumor Subtype;Tumor-associated macrophages;tumor-immune system interactions;United States;Variant;Work

PROJECT_TITLE: Delineating the myeloid-centric immunosuppressive crosstalk as targets for prognosis and therapy in neuroendocrine tumors

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-K (O1)]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: Project Narrative Studies of novel functional genetic variants underlying human disease will provide valuable information to the general scientific community that will have broad relevance across many disciplines. We will systematically characterize the genetic variants in human disease genes in zebrafish to determine the functional consequence of such mutations and develop approaches to test the disease-causing variants functionally. The information and resources generated from our studies will impact a broad spectrum of researchers studying multiple human diseases.

PI_NAMEs: VARSHNEY, GAURAV K (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: Acceleration;Adenine;Affect;Alleles;Animal Model;Animals;Auditory system;base editing;base editor;Behavior;Behavioral Assay;behavioral phenotyping;Biological Assay;Candidate Disease Gene;candidate identification;candidate validation;cell type;Cellular Assay;clinical phenotype;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;CRISPR/Cas technology;Custom;Cytosine;Databases;Deaminase;Development;Diagnosis;Discipline;Disease;disease model;disease phenotype;disease-causing mutation;DNA;Engineering;Enzymes;exome sequencing;Fertilization;Functional disorder;gain of function;gene editing technology;gene function;Gene Silencing;Generations;Genes;Genetic;genetic manipulation;Genetic study;genetic variant;Genome;genome wide association study;Goals;human disease;Image;improved;in vivo;Information Networks;insight;International;Knock-out;knockout gene;Libraries;Link;loss of function;Mendelian disorder;Methods;model organism;Modeling;Morphology;Mus;Muscle;mutant;Mutation;novel;Nucleotides;Pathologic;Pathology;Phenotype;phenotypic data;Point Mutation;Published Comment;Rapid screening;rapid technique;Reporter;Reporter Genes;Research;Research Personnel;Resources;Single Nucleotide Polymorphism;skeletal;Standardization;System;Technology;Testing;Time;Tissues;tool;Transgenic Organisms;treatment strategy;Validation;Variant;Visual;Xenopus;Zebrafish

PROJECT_TITLE: Development of scalable methods for rapid phenotyping and functional testing of variants

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-Y (55)]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PHR: PROJECT NARRATIVE To design better malaria vaccines, we propose to learn from nature by studying immune responses against the malaria parasite in people who have developed protection against the disease as a result of life-long exposure. This project will compare antibodies from malaria-protected and susceptible individuals to determine the characteristics of antibodies that a malaria vaccine should elicit. In addition, antibodies that are able to strongly inhibit the parasite will be analyzed in more detail to serve as a blueprint for malaria vaccine design.

PI_NAMEs: BUNNIK, EVELIEN MARGARETHA (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: acquired immunity;Adult;Affinity;Antibodies;Antibody Response;Antibody-mediated protection;Antigens;B cell differentiation;B-Cell Antigen Receptor;B-Cell Development;Binding;Biological Assay;Blood;Cell Lineage;Cessation of life;Characteristics;Child;Clinical;cohort;Complex Mixtures;Data;design;Disease;Epitope Mapping;Epitopes;Erythrocytes;experience;experimental study;Failure;falls;fighting;Freezing;Genes;Genetic Polymorphism;Genetic Variation;Immune;Immune response;Immunity;Immunoglobulin Class Switching;Immunoglobulin G;Immunoglobulin M;Immunoglobulin Somatic Hypermutation;Immunologics;Immunology;In Vitro;Individual;Infection;insight;Invaded;Knowledge;Learning;Life Cycle Stages;Malaria;malaria transmission;Malaria Vaccines;Maps;Mass Spectrum Analysis;Memory;Memory B-Lymphocyte;Molecular;Monoclonal Antibodies;Morbidity - disease rate;mortality;Mutagenesis;Nature;next generation;novel;Parasites;Parasitology;Passive Immunization;Peripheral Blood Mononuclear Cell;Persons;Plasma Cells;Plasmodium falciparum;Positioning Attribute;Predisposition;prevent;Proteomics;response;Reverse engineering;Serology;Serum;Sporozoite vaccine;Sporozoites;structural biology;Structure;Testing;tool;Transcend;Uganda;Vaccination;vaccine candidate;Vaccine Design;vaccine development;vaccine trial;Vaccines;Variant;X-Ray Crystallography

PROJECT_TITLE: Defining conserved epitopes on polymorphic malaria antigens

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Genetics;Hepatitis;Hepatitis - B;Human Fetal Tissue;Infectious Diseases;Liver Disease

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE Hepatitis B virus (HBV) is an important human pathogen. There are approximately 300 million people in the world that are chronically infected by this virus, resulting in nearly 1 million deaths every year. The goal of our proposed research is to produce novel therapeutic agents for the treatment of this important viral disease.

PI_NAMEs: OU, J.-H. JAMES  (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: Adverse effects;analog;Animals;anti-hepatitis B;Antibodies;Appearance;Applications Grants;Binding;CD8-Positive T-Lymphocytes;Cell Culture Techniques;Cell model;Cell Nucleus;Cells;Cessation of life;Chronic;Chronic Hepatitis B;Cirrhosis;cytokine;Data;Diabetes Mellitus;DNA;DNA Sequence;Enhancers;entecavir;Excision;FDA approved;FOXO3A gene;Gene Expression;Genomic DNA;Goals;Grant;Hepatitis B Therapy;Hepatitis B Virus;Hepatocyte;hepatoma cell;Human;human pathogen;humanized mouse;Immune response;Immune system;improved;in vivo;inhibitor;Interleukin-1 beta;Lead;Liver diseases;Mediating;Modeling;mouse model;Mus;Names;novel therapeutics;Patients;Persons;Pharmaceutical Preparations;Phase;PPAR alpha;Primary carcinoma of the liver cells;repaglinide;Research;response;RNA-Directed DNA Polymerase;small molecule;success;Surface Antigens;Telbivudine;Tenofovir;Testing;Therapeutic Agents;Time;transcription factor;Transgenic Mice;Treatment Cost;Viral;Viral Genes;Viral Genome;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: IL-1β as a novel therapeutic agent against hepatitis B virus

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 SAS-M (S2)]