ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: NARRATIVE The proposed Resource for Elemental Imaging for the Life Sciences (QE-Map) will advance and integrate new and current technologies in an integrated workflow to create transformative approaches to the compelling biological question of the role of metals, and other inorganic elements, in health and disease.

PI_NAMEs: JACOBSEN, CHRIS JOHNSON;O'HALLORAN, THOMAS V (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Acceleration;Address;Advisory Committees;Affect;Animals;applied biomedical research;Automobile Driving;Biological;Biological Markers;Biological Process;Biological Sciences;Biology;Biomedical Research;Brain;Cell Cycle;Cell Extracts;cell fixing;Cell Physiology;Cells;Chemicals;Chemistry;Collaborations;Communities;community engagement;Computer software;Coordination and Collaboration;Copper;Core Facility;Country;Data;design;detection method;Development;Diagnosis;Disease;Ecosystem;Elements;Emerging Technologies;Engineering;Faculty;faculty research;Fluorescence Microscopy;Fostering;fundamental research;Genes;Goals;Growth;Health;Human;Human Genome;Image;imaging modality;indexing;Inductively Coupled Plasma Mass Spectrometry;Infection;Infrastructure;Inorganic Chemistry;Ions;Iron;Laboratories;Leadership;Life;Link;Location;Mammalian Cell;Maps;meetings;Metabolic;Metabolic Diseases;Metabolism;Metals;Methods;Modeling;multidisciplinary;Nature;Nerve Degeneration;Nervous System Physiology;new technology;Organism;pathogen;Pathogenicity;Pathologic;Pathology;Phenotype;photoacoustic imaging;Photons;Physics;Physiological;Physiology;Play;Population;Positioning Attribute;Preparation;Process;programs;Proteins;Quantitative Evaluations;recruit;Regulation;Reproduction;Research;research and development;Research Personnel;Resource Allocation;Resources;Roentgen Rays;Role;Sampling;Scanning;Scholars Program;Science;single cell technology;Slice;Source;Standardization;Technology;technology development;technology research and development;Tissues;Training;training opportunity;Transition Elements;United States National Institutes of Health;Universities;visiting scholar;Work;Zinc

PROJECT_TITLE: Resource for Quantitative Elemental Mapping for the Life Sciences

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T(40)P]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

PI_NAMEs: O'HALLORAN, THOMAS V (contact)

PROJECT_TERMS: Administrator;Adopted;Advisory Committees;Appointment;Astronomy;Automobile Driving;Biological;Biological Process;Biological Sciences;Biomedical Research;Chemistry;Collaborations;Communication;Communities;community engagement;Core Facility;cost;Development;Diagnosis;Disease;Doctor of Philosophy;Elements;Ensure;Evaluation;experience;Faculty;Fluorescence;Fostering;Funding;Goals;imaging facilities;Inductively Coupled Plasma Mass Spectrometry;Infrastructure;instrument;instrumentation;Joints;Laboratories;Lead;Leadership;Life;Maps;meetings;Methods;Microscopy;Mission;Modeling;Molecular;multidisciplinary;Office of Administrative Management;operation;Peer Review;Performance;Photons;Physics;Policies;Principal Investigator;Procedures;Process;professor;programs;Publications;Recommendation;Recording of previous events;Reporting;Research;Resource Allocation;Resource Sharing;Resources;Roentgen Rays;Schedule;Science;Services;Source;Strategic Planning;synergism;Technology;technology development;technology research and development;Universities;Work;X ray microscopy

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: 3-Dimensional;Ablation;absorption;Adopted;Automobile Driving;beamline;Beds;bioimaging;Biological;Biological Preservation;Biological Process;Biological Sciences;biological systems;Brain;Calibration;Cells;Certification;Chemistry;Communities;Complement;Complex;Computer software;Coupled;Crustacea;cryogenics;Data;data acquisition;Data Analyses;data reduction;Data Set;design;detection limit;detector;Development;Disease;Elements;Ensure;Equilibrium;Fresh Water;Functional disorder;Goals;Grain;Heterogeneity;Homeostasis;Hour;Image;Image Analysis;imaging approach;imaging capabilities;imaging facilities;Imaging Techniques;Imaging technology;improved;Individual;Inductively Coupled Plasma Mass Spectrometry;Institution;Interruption;Lasers;Lead;Left;Link;Maps;mass spectrometric imaging;Mass Spectrum Analysis;Metabolic;Metals;Methods;Multimodal Imaging;Mus;open source;Organ;Organism;pathogen;Pathology;photoacoustic imaging;Physiological Processes;Plasma;Play;Preparation;preservation;Procedures;Process;Production;Protocols documentation;Pythons;Reference Standards;Reporting;Reproduction;Research Personnel;Resolution;Resources;Risk;Role;Rye cereal;Sampling;Sectioning technique;Services;spatiotemporal;Specificity;Standardization;Structure;System;Systems Integration;Techniques;technology research and development;Testing;Three-Dimensional Image;Three-Dimensional Imaging;Time;time of flight mass spectrometry;tissue reconstruction;Tissues;trafficking;Validation;Variant;Visualization;Wheat

PROJECT_TITLE: TR&D Project 1: Higher Throughput Multi-element Distribution & Quantitation at the Tissue Level


ADMINISTERING_IC: HL

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Obesity;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Cardiometabolic diseases (CMD), including obesity, dyslipidemia, type 2 diabetes, and hypertension, disproportionately impact Hispanic and Latino people and are the leading cause of disease burden in the world. Despite decades of genetic research, little is understood about how gene expression measures impact and are impacted by CMD. Therefore, we propose to study the relationship of gene expression measures genome-wide in two key metabolic tissues (whole blood and abdominal subcutaneous adipose tissue) with CMD and its progression in Hispanic and Latino people to garner a better understanding of the relationship between gene expression and CMD.

PI_NAMEs: BELOW, JENNIFER  (contact);MCCORMICK, JOSEPH ;NORTH, KARI E.

PROGRAM_OFFICER_NAME: KUNZ, JOHN FREDERIC

PROJECT_TERMS: Abdomen;Address;Adipose tissue;African;American Indians;burden of illness;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;cell type;Central obesity;clinically relevant;cohort;County;Data;Data Set;design;Diagnostic;differential expression;Disease Progression;disorder prevention;disorder risk;Dyslipidemias;epidemiologic data;Equilibrium;Etiology;experience;follow-up;Funding;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic;genetic analysis;Genetic Research;genetic risk factor;genome wide association study;genome-wide;genomic data;Genomics;Goals;Health;health disparity;Hispanic;Hispanic Community Health Study/Study of Latinos;Hispanic Populations;Hypertension;Individual;innovation;insight;Intervention;Latino;Latino Population;Link;Lipids;Longitudinal Studies;marginalized population;Measures;Mendelian randomization;Metabolic;Methods;Mexican;Mission;Molecular;Molecular Profiling;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Paper;Participant;Pathogenesis;Pathway interactions;Patient Recruitments;Pattern;Persons;Pharmacologic Substance;Population;Population Study;precision medicine;Prevention;Publications;Publishing;recruit;Research;Resources;Risk Factors;RNA;Role;sample collection;Sampling;Serum;Signal Transduction;Specimen;subcutaneous;success;Time;Tissue Sample;Tissues;trait;Transcriptional Regulation;transcriptome sequencing;transcriptomics;translational pipeline;Translations;Underrepresented Populations;United States;United States National Institutes of Health;Validation;Variant;Vulnerable Populations;Whole Blood;Work

PROJECT_TITLE: Hispanic Latino Lipid Consortium

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

ORG_STATE: NY

PHR: PROJECT NARRATIVE (PUBLIC HEALTH RELEVANCE) African American (AA) women have a higher risk of being diagnosed with aggressive breast cancer and have the highest mortality rate among all racial groups in U.S. women. We will systematically elucidate the role of long noncoding RNAs (lncRNAs), a novel class of regulatory molecules, in breast cancer prognosis in AA women. This work is new and is anticipated to advance our understanding of molecular mechanisms contributing to the aggressive tumor biology and poor cancer prognosis observed in AA women.

PI_NAMEs: GONG, ZHIHONG  (contact)

PROGRAM_OFFICER_NAME: FILIPSKI, KELLY

PROJECT_TERMS: Aberrant DNA Methylation;African American;African American Women;aggressive breast cancer;American;Biological;Biological Assay;Breast Cancer Patient;breast cancer survival;cancer health disparity;Cancer Prognosis;carcinogenesis;Cells;Characteristics;Clinical;Code;cohort;cost effective;Data;Death Rate;Development;Diagnosis;diagnostic biomarker;Diet;differential expression;Disease;Disparity;DNA Methylation;Environmental Exposure;epidemiologic data;Estrogen Receptor Status;Estrogen Receptors;European;Exhibits;experience;Expression Profiling;gene function;Genes;Genetic Transcription;genome-wide;genome-wide analysis;HAS2 gene;Health;health care availability;high risk;In Vitro;Knowledge;Life Style;lifestyle factors;Machine Learning;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammary Neoplasms;Methylation;MicroRNAs;Molecular;mortality;Mutation;next generation sequencing;Normal tissue morphology;novel;Obesity;Outcome;overexpression;Patients;Pattern;Pilot Projects;Play;Prevention strategy;Prognosis;Prognostic Marker;Promoter Regions;Proteins;public health relevance;Race;racial difference;racial disparity;racial population;Regulation;Research;Role;Socioeconomic Factors;Specificity;targeted treatment;Therapeutic;therapeutic target;Tissue Banks;Tissues;transcriptome;transcriptome sequencing;Translating;tumor;Tumor Biology;tumor growth;tumor progression;Tumor Promotion;Tumor Tissue;Untranslated RNA;Validation;Woman;women patients;Work

PROJECT_TITLE: Long noncoding RNA regulations in breast cancer among African-American women

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: JACOBSEN, CHRIS JOHNSON (contact)

PROJECT_TERMS: 3-Dimensional;Ablation;absorption;Area;Automobile Driving;beamline;Biological Sciences;Brain;Cells;cellular imaging;chemical standard;Chemicals;Code;Communities;computer program;Computer software;confocal imaging;cost;cryogenics;Dedications;Department of Energy;Development;Dyes;Elements;experience;Fluorescence;fluorescence imaging;Fluorescence Microscopy;Funding;Homeostasis;Image;Image Analysis;image visualization;imaging modality;Inductively Coupled Plasma Mass Spectrometry;instrument;Label;Laboratories;Lasers;Length;Light;Light Microscope;light microscopy;Machine Learning;Maps;Metabolic;Metals;meter;Methodology;Methods;Microscope;Microscopy;Modality;Modeling;nanoscale;novel strategies;open source;open source tool;operation;Organ;Pathology;Peer Review;Photons;Preparation;preservation;Production;programs;Proteins;prototype;Pythons;quantitative imaging;Quantitative Microscopy;Radiation induced damage;reconstruction;Reproduction;Research Personnel;Resistance;Resolution;Resources;Roentgen Rays;Sampling;Scanning;Schedule;Self Correction;Signal Transduction;Slice;Source;Specimen;spectroscopic imaging;Structure;supercomputer;Synchrotrons;System;technology research and development;TensorFlow;Thick;Three-Dimensional Imaging;Time;Tissues;tomography;tool;Trace Elements;transmission process;United States National Institutes of Health;X ray microscopy;X-Ray Tomography

PROJECT_TITLE: TR&D Project 2: Tissue and cellular elemental distribution, and image correlation


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Comparative Effectiveness Research;Depression;Health Services;Mental Health;Mental Illness;Primary Health Care

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative This proposed project is relevant to public health because it will evaluate the impact of the largest outpatient value-based payment program in the U.S. on patient access to evidence-based treatment for depression and anxiety disorders in the primary care setting, potentially improving the quality of primary care for the large number of Medicare beneficiaries with these conditions. The project is relevant to the National Institute on Mental Health's mission to use real-world medical claims, survey, and clinician data to identify, evaluate, and validate national innovative primary care payment and service delivery models on their impact on access to care, evidence-based treatment rates, health outcomes, and costs of care.

PI_NAMEs: JOHNSTON, KENTON JAMES (contact)

PROGRAM_OFFICER_NAME: HUMENSKY, JENNIFER L

PROJECT_TERMS: accountable care organization;acronyms;Acute;Adopted;Anxiety Disorders;anxiety symptoms;behavioral health;beneficiary;care costs;care delivery;care outcomes;Caring;Chronic;Clinical;collaborative care;comorbidity;cost;cost outcomes;Data;data centers;depressive symptoms;design;Detection;Diagnosis;disability;Disincentive;Disparity;Event;evidence base;evidence based guidelines;Evidence based treatment;experience;financial incentive;Financial Risk Sharing;Fostering;functional status;Health;Health Expenditures;Health Services Accessibility;high risk;Improve Access;improved;incentive program;Incentives;Individual;innovation;Longitudinal Studies;Medical;Medicare;Mental Depression;Mental Health;Mission;Modeling;National Institute of Mental Health;Outcome;Outpatients;Patient Care;patient centered medical home;patient population;Patient-Focused Outcomes;Patients;payment;peer;Performance;Physicians;Policy Maker;Primary Care;primary care practice;primary care provider;primary care setting;programs;Public Health;Research;Research Support;Retrospective cohort study;Risk;Risk Adjustment;Savings;screening;screening guidelines;Service delivery model;Services;Surveys;System;Translating;United States Centers for Medicare and Medicaid Services;virtual

PROJECT_TITLE: Can the Medicare Quality Payment Program Incentivize Evidence-Based Treatment of Depression and Anxiety Disorders by Primary Care Providers?

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


PI_NAMEs: ZHANG, HAO F (contact)

PROJECT_TITLE: TR&D Project 3: Photoacoustic Detection of Metal Fluxes at the Tissue Level


PROJECT_TERMS: Acceleration;Address;Adoption;Advisory Committees;Affect;Anatomy;Automobile Driving;Base Pairing;Basic Science;Beds;Biological;Biological Process;Biological Sciences;Biology;Biomedical Research;Brain;Cell Cycle;Cell Extracts;cell fixing;Cell Physiology;Cells;Cellular biology;Chemicals;Clinical Research;cofactor;cohort;Collaborations;Communication;Communities;Consultations;Copper;detection method;Development;Dimensions;Disease;Disease Progression;Elements;Emerging Technologies;Enzymes;Evaluation;Foundations;Funding;Genes;Genome;Goals;Health;Human;Human Genome;Human Resources;Image;imaging modality;Infection;Inorganic Chemistry;Ions;Iron;IT collaborator;Leadership;Location;Mammalian Cell;Manganese;Maps;meetings;Metabolic;Metals;Methods;Molecular;Nervous System Physiology;new technology;Onset of illness;pathogen;Pathogenesis;Pathogenicity;Pathologic;Pathology;Periodicals;Phenotype;Physiological;Physiological Processes;Physiology;Play;Population;Principal Investigator;Process;programs;Proteins;Quantitative Evaluations;quantitative imaging;recruit;Regulation;Reporter;Reproducibility;Reproduction;Research;Research Personnel;Resources;response;Role;Sampling;Slice;Stimulus;success;symposium;Technology;technology development;technology platform;Teleconferences;Testing;Tissues;Transition Elements;United States National Institutes of Health;Update;Variant;Work;Zinc

PROJECT_TITLE: Developing Biomedical Projects Portfolio


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Neurodegenerative

ORG_CITY: LA JOLLA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative: 99% of the mitochondrial proteome is encoded by nuclear genes and require the coordinated efforts of dedicated mitochondrial protein import machinery for the proper import, sorting, and folding of these cytosolically-translated proteins. Although it is well-understood that these processes are so critical for sustaining the numerous mitochondrial functions that are necessary for maintaining normal human physiology, modern medicine's ability to combat human disorders such as neurodegeneration and cancer are hampered by our limited structural understanding these protein import machineries. My proposed research under this award will utilize targeted biochemical strategies and groundbreaking technological developments in electron cryomicroscopy to pioneer studies of these critically important protein import complexes, providing insights into how their dysfunction leads to alterations in the protein content of the mitochondria and progression of the disease state.

PI_NAMEs: HERZIK, MARK ANTHONY (contact)

PROJECT_TERMS: 3-Dimensional;Architecture;Award;Biochemical;Bioenergetics;Biogenesis;Biological Assay;Cells;combat;Communities;Complex;computerized data processing;Cryoelectron Microscopy;Data Collection;Dedications;Disease;Disease Progression;Electrons;Functional disorder;Genes;Human;In Vitro;insight;light microscopy;Malignant Neoplasms;Membrane;Metabolic;Methodology;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modeling;Modern Medicine;Molecular;Molecular Conformation;Motion;Natural Source;Nerve Degeneration;Neurodegenerative Disorders;novel;Nuclear;Outer Mitochondrial Membrane;Oxidative Phosphorylation;Pathologic;Physiology;Preparation;Process;Protein Import;Protein Precursors;Proteins;Proteome;Research;Resolution;Ribosomes;Risk Factors;Role;Sampling;Signal Transduction;Sorting;Structure;Technology;technology development;Testing;Translating;translocase

PROJECT_TITLE: Towards an Atomistic Understanding of Mitochondrial Protein Biogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Genetics

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Successful treatments for atherosclerotic heart disease reduce the “bad” cholesterol in the bloodstream, but further therapies are needed, underscoring the public health relevance of this proposal. These challenges will be addressed by 1) understanding how a recently uncovered gene decreases the body's ability to clear “bad” cholesterol, and 2) establishing whether the beneficial effects of inhibiting this gene extend beyond a cell culture dish and into a whole organism. Since the results will determine whether this gene could be a future drug target, as well as how a drug would have to work against it, this proposal is directly relevant to the NIH mission of promoting fundamental discoveries and innovative research designs as a basis for improving human health.

PI_NAMEs: CHORBA, JOHN S (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: 3' Untranslated Regions;Acceleration;Address;Affect;Atherosclerosis;Berberine;Binding;Biological;Blood Circulation;blood lipoprotein;Cardiovascular system;Cause of Death;Cell Culture Techniques;Cell membrane;Cell model;Cell surface;Cells;Cellular biology;Cholesterol;Cholesterol Homeostasis;Clinic;Communicable Diseases;Coronary heart disease;CRISPR interference;crosslink;Data;Development;Disease;Drug Targeting;Elements;Endotoxins;Environment;Event;Future;Gene Expression Profiling;Genes;genome-wide;Goals;Health;Heart Diseases;Hepatic;Human;Immunoprecipitation;improved;in vivo;Inflammatory;inhibitor;innovation;insight;knock-down;Lipids;Liver;Low Density Lipoprotein Receptor;Low-Density Lipoproteins;Maintenance;Mass Spectrum Analysis;Mediating;Messenger RNA;Mission;Modeling;modifiable risk;Molecular Chaperones;mouse model;mRNA Decay;mRNA Stability;Natural Compound;novel;overexpression;Pathway interactions;Pharmaceutical Preparations;Plasma;Play;Post-Transcriptional Regulation;posttranscriptional;Proteins;public health relevance;receptor expression;recruit;Regulation;Research Design;Risk Factors;RNA;RNA Binding;Role;Specificity;Surface;System;Therapeutic;therapeutic target;tissue culture;Tissues;Transcript;Transcriptional Regulation;transcriptome;transcriptome sequencing;United States;United States National Institutes of Health;uptake;Virus;Whole Organism;Work

PROJECT_TITLE: CSDE1 as a Post Transcriptional Regulator of the LDLR

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

PI_NAMEs: MACRENARIS, KEITH W (contact)

PROJECT_TERMS: Acceleration;Address;Adopted;Adoption;Advisory Committees;Area;Automobile Driving;Award;Awareness;base;Biological Sciences;Biology;Biomedical Research;Charge;Chemistry;Clinical Research;Collaborations;commercialization;Communities;community engagement;Computer software;Consultations;Core Facility;cost;data acquisition;Data Analyses;Detection;Development;Disease;disease model;Educational workshop;efficacy evaluation;Elements;Ensure;Evaluation;experience;Fostering;Funding;Goals;Grant;Guidelines;Health;Human;Human Resources;Image;improved;innovation;instrument;instrumentation;Internet;Investigation;Journals;Leadership;Legal patent;Length;Life;Maps;meetings;Metals;Methods;Microscopy;model organism;Movement;new technology;Newsletter;online tutorial;pathogen;Peer Review;Preparation;Press Releases;Process;Professional Organizations;programs;prospective;Protocols documentation;Publications;Publishing;Research;Research Personnel;Resource Allocation;Resources;Review Literature;Sampling;Scholars Program;Services;social media;Specific qualifier value;Students;symposium;Technology;technology development;Time;Training;Training Activity;United States National Institutes of Health;Visit;visiting scholar;web site

PROJECT_TITLE: Community Engagement


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: WHITE PLAINS

ORG_NAME: WINIFRED MASTERSON BURKE MED RES INST

PHR: Corticospinal circuits are essential for skilled movement. In humans, interruption of motor circuits caused by spinal cord injury, stroke, or other disorders results in severe deficits in most fine motor skills. Therefore, understanding the cellular and molecular mechanisms underlying corticospinal circuits will provide important information for developing new therapeutic avenues for addressing diseases and injuries related to motor circuits in humans.

PI_NAMEs: YOSHIDA, YUTAKA  (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Address;Adult;Affect;Antibodies;Area;Axon;Behavior;Biological Assay;Brain;Calcium;Cerebral cortex;Data;Dendrites;Development;Disease;effective therapy;Electromyography;Electrophysiology (science);Exhibits;Extensor;Flexor;Forearm;Forelimb;Funding;Genetic;Goals;grasp;Human;Image;imaging study;Impairment;Injury;Interneurons;Interruption;Intervention;Limb structure;Maintenance;Mammals;Maps;Methods;Molecular;Motor;Motor Activity;motor behavior;motor control;Motor Cortex;Motor disability;motor disorder;Motor Neurons;Motor Skills;mouse development;Movement;Mus;Muscle;neural circuit;Neurons;novel;novel therapeutics;optogenetics;Output;Parkinson Disease;Pattern;Phase;Population;presynaptic;presynaptic neurons;Proprioceptor;Rabies virus;Research;Rodent;Role;sensory cortex;skills;Spinal;Spinal Cord;Spinal cord injury;Spinal Ganglia;Stroke;Synapses;System;Testing;Thalamic structure;Therapeutic;therapeutic target;therapy design;Time;Virus

PROJECT_TITLE: Presynaptic Partners of Corticospinal Neurons to Control Skilled Movements

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Climate-Related Exposures and Conditions;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Data Science;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Neurodegenerative;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: ALBANY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

PHR: NARRATIVE The proposed study will evaluate if and how multiple weather factors and/or natural disasters jointly affect the most fatal diseases in the aging population, including cardiovascular disease, respiratory diseases, Alzheimer’s (and other forms of dementia), unintentional injuries, and renal disease, and if the exposures to these weather extremes and related health impacts are different by different socioeconomic status (SES) among older adults. This may be the first study to utilize the comprehensive meteorological data collected by Mesonet, the remote sensing data, and over 300 environmental variables to create daily high-resolution gridded weather data (1km*1km or finer), and to assess nationwide COVID-19 infection/death after weather extremes. The health risk predictive models based on multiple SES, social, environmental, and community risk factors using data science methods, the vulnerability and resilience index/map, and culturally appropriate communication materials will help guide state and/or federal environmental and health agencies to plan interventions and adaptation programs, specifically for the aging population.

PI_NAMEs: LIN, SHAO  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: Accidental Injury;Address;Adverse effects;Affect;Aging;aging population;Alzheimer's Disease;Behavior;Cardiovascular Diseases;Cessation of life;Chronic Obstructive Pulmonary Disease;climate change;cohort;Communication;Communities;community setting;community-level factor;contextual factors;COVID-19 pandemic;Critical Care;Data;data integration;data mining;Data Science;Data Set;Death Rate;deep learning;Dementia;Development;Disasters;Disease;Disparity;Environment;Environmental Risk Factor;Environmental Wind;Ethics;ethnic diversity;Event;evidence base;experience;Exposure to;extreme heat;extreme weather;Face;Floods;follow-up;Government Agencies;Grant;hazard;Health;health assessment;health data;health disparity;Heat Waves;hospital readmission;Hospitalization;Human;Hurricane;Ice;improved;indexing;Individual;Injury;innovation;Interruption;Intervention;Joints;Kidney Diseases;low socioeconomic status;machine learning algorithm;Maps;Mediation;member;meteorological data;Meteorological Factors;Methodology;Methods;Minority;Minority Groups;Modeling;Monitor;Morbidity - disease rate;mortality;multidisciplinary;Natural Disasters;Non-linear Models;older adult;Outcome;pandemic disease;Population;Population Heterogeneity;Positioning Attribute;Precipitation;predictive modeling;Predisposition;Probability;programs;public health priorities;racial diversity;Radiation;Readiness;Recording of previous events;remote sensing;Research;Research Personnel;resilience;resilience factor;Resolution;Resources;Respiratory Disease;response;Risk;Risk Factors;risk prediction model;rural area;SARS-CoV-2 infection;Seasons;simulation;Site;social;Social Environment;social factors;Socioeconomic Status;spelling;success;Techniques;Testing;Time Series Analysis;vulnerable community;Vulnerable Populations;Weather;weather variables;weather-related disaster;web site;Wildfire;Work

PROJECT_TITLE: Weather extremes, natural disasters, and health outcomes among vulnerable older adults: New improvements on exposure assessment, disparity identification, and risk communication strategies

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Biotechnology;Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW HAVEN

ORG_DEPT: PHARMACOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative How cells respond to the environment is a fundamental process required for normal development, and homeostasis and that is altered in disease. Our proposed studies aim to understand the role of the post-transcriptional RNA modification m6A as a critical component of the repertoire of tools that cells use to adapt to extracellular cues and the mechanisms involved in this regulation. The success of the research proposed here will not only expand our understanding of basic tools that cells use to respond to their environment but will have the potential to identify novel pathways and therapeutic targets implicated in disease.

PI_NAMEs: ALARCON, CLAUDIO R (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Area;Biochemistry;Biology;Cell Physiology;Cell Proliferation;Cell Survival;Cells;Cellular biology;Complement;Cryoelectron Microscopy;Cues;Development;Disease;embryonic stem cell;Engineering;Environment;Enzymes;epitranscriptome;Event;extracellular;Gene Expression Regulation;Homeostasis;Human;interdisciplinary approach;Knowledge;Meiosis;Messenger RNA;Metabolic;Metabolic stress;Methylation;Methyltransferase;MicroRNAs;Modification;Molecular;Molecular Biology;mouse model;novel;Pathway interactions;Post-Transcriptional RNA Processing;Post-Translational Protein Processing;posttranscriptional;Process;Program Description;Proliferating;protein complex;Proteomics;Reaction;Regulation;Research;RNA;RNA metabolism;RNA Splicing;RNA Stability;Role;Signal Pathway;Signal Transduction;Specificity;stem cell differentiation;stem cell self renewal;success;Techniques;therapeutic target;Tissues;tool;transcriptome;X-Ray Crystallography;Yeasts

PROJECT_TITLE: Mechanisms of Regulation of the m6A mRNA Methylation Machinery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative The CBPH attempts to clarify the cellular, molecular and biological pathways through which social, economic, and psychological and experiences impact health with aging and create differential health. This is accomplished through the development of valid and reliable biological measurement appropriate for population studies, the integration of networks of experts on novel biological processes into the demographic research community, and the support of cutting edge research. Such knowledge is essential to improve our ability to improve health and reduce health disparities.

PI_NAMEs: AILSHIRE, JENNIFER A;COLE, STEVE W;CRIMMINS, EILEEN M (contact);SEEMAN, TERESA E

PROGRAM_OFFICER_NAME: BRAUDT, DAVID BRUCE

PROJECT_TERMS: Address;Affect;age related changes;Aging;aging mechanism;analytical tool;Area;Behavioral;biodemography;Biological;Biological Markers;Biological Process;Biology;California;Cell Physiology;Clinical;Cognitive aging;cohort;Collaborations;Communities;community engagement;Country;Data;Data Analyses;Data Collection;Demography;design;Development;Disadvantaged;Dissemination and Implementation;Economics;Educational process of instructing;effective intervention;Environmental Risk Factor;Epigenetic Process;experience;Fostering;Funding;Generations;Genomics;Geriatrics;Gerontology;Goals;Health;health disparity;health inequalities;human old age (65+);improved;Infrastructure;innovation;innovative technologies;Institution;International;Intervention;Knowledge;Laboratories;Leadership;Life;Life Cycle Stages;Los Angeles;Measurement;Measures;Medical;medical schools;Methodological Studies;Methodology;Modeling;Molecular;novel;Outcome;Pathway interactions;Pilot Projects;Play;Policies;Population;population health;Population Study;population survey;Process;Program Development;programs;Protocols documentation;psychologic;Reduce health disparities;Research;Research Activity;research and development;research data dissemination;Research Personnel;Research Support;Resources;Risk;Role;Schools;Science;Scientific Advances and Accomplishments;Skin;social;Subgroup;success;Surveys;Technology;technology development;theories;Universities;Validation

PROJECT_TITLE: USC/UCLA Center on Biodemography and Population Health


NIH_SPENDING_CATS: Asthma;Biotechnology;Genetics;Lung

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE: Human airway smooth muscle (HASM) represents the pivotal cell regulating bronchomotor tone. However, our incomplete understanding of type 2 (T2) inflammation-regulated excitation-contraction (E-C) coupling in HASM shortening has, for the past 60 years, hindered the development of new HASM bronchodilators in the treatment of obstructive lung disease. We assert that studying the molecular mechanisms of excitation-contraction (E-C) coupling that differentiate HASM shortening in asthma- and non-asthma-derived cells/tissues will uncover novel mechanical endotypes of airflow obstruction (inflammation-dependent and -independent) and identify improved bronchodilators that are less susceptible to tolerance and less affected by immune inflammatory responses in asthma.

PI_NAMEs: AN, STEVEN S (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: Acute;Adjuvant Therapy;Adrenergic Receptor;Adverse effects;Affect;Agonist;airway inflammation;airway obstruction;airway remodeling;Anti-Inflammatory Agents;Asthma;Biological Products;Bronchial Spasm;Bronchodilation;Bronchodilator Agents;Calcium;Cells;Chronic;Clinical;clinically relevant;cohort;computer studies;Coupling;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;cytokine;Data;desensitization;Development;Drug Tolerance;Enhancers;Epigenetic Process;Event;experimental study;Family;G-Protein-Coupled Receptors;genetic approach;Genetic Transcription;Genomic approach;Goals;Homologous Gene;Human;Immune;Immune response;Immunologics;improved;In Vitro;in vivo Model;Inflammation;Inflammatory Response;insight;Interleukin-13;Kinetics;Knowledge;Lung;Mechanics;Mediating;Mediator;Methods;MicroRNAs;Molecular;Mus;Muscle relaxation phase;new therapeutic target;non-genetic;novel;Obstruction;Obstructive Lung Diseases;Pathogenicity;Patients;Persons;Pharmaceutical Preparations;Physiological;Polycomb;Pre-Clinical Model;Predisposition;Property;Proteins;Psychological reinforcement;Receptor Activation;Receptor Inhibition;Regulation;Regulatory Element;Relaxation;release of sequestered calcium ion into cytoplasm;Research;respiratory smooth muscle;Role;Sensory;Signal Transduction;single molecule;Slice;Smooth Muscle Myocytes;Tachyphylaxis;Taste Buds;technological innovation;Therapeutic;Tissues;Transcription Repressor;Transforming Growth Factor beta;Translational Repression;Work

PROJECT_TITLE: Targeting T2 inflammation-evoked mechanical endotypes of ASM shortening in asthma

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Aging

PI_NAMEs: CRIMMINS, EILEEN M (contact)

PROJECT_TERMS: Address;Affect;aging demography;aging mechanism;Area;biodemography;Biological;Biological Assay;Biological Markers;Biological Process;biological research;Clinic;Collection;Communities;Data;Demographic Analyses;design;Development;DNA Methylation;Education;Epidemiology;Epigenetic Process;experience;Faculty;Fostering;functional genomics;Genetic;Genomics;Goals;Growth;Health;improved;Infrastructure;innovation;Institution;International;Joints;Knowledge;Leadership;Lived experience;Measurement;Measures;meetings;Methodology;Methods;Molecular;Morbidity - disease rate;mortality;novel marker;operation;organizational structure;Outcome;Pathway interactions;Pilot Projects;Play;Population;population health;Population Study;population survey;Program Development;programs;Protocols documentation;Research;Research Activity;research and development;research data dissemination;Research Methodology;Research Personnel;Research Support;Resources;RNA;Role;Scientific Advances and Accomplishments;Services;Teacher Professional Development;theories;transcriptomics;trend

PROJECT_TITLE: USC/UCLA Center for Biodemography and Population Health: Core A


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Social Determinants of Health

PI_NAMEs: ZISSIMOPOULOS, JULIE M (contact)

PROJECT_TERMS: Acceleration;Address;Affect;age acceleration;Aging;aging brain;aging mechanism;Area;Behavior;Behavioral;biodemography;Biological;Biological Markers;Biological Process;Brain;career;Cell Aging;Cell Physiology;Cells;Chronic;Cognition;Cohort Studies;Communities;Data;Development;DNA;DNA Methylation;early-career faculty;Economic Factors;Economics;epigenetic aging;Epigenetic Process;Faculty;Flow Cytometry;Fostering;functional genomics;Funding;Gene Expression;Genetic;Goals;Grant;Health;Health and Retirement Study;health disparity;Healthcare;human old age (65+);Inflammation;Inflammatory;innovation;interest;late life;Lead;Life;Life Cycle Stages;Life Stress;Link;Lived experience;Magnetic Resonance Imaging;Measurement;Mediating;meetings;Mercury;Methods;middle age;Molecular;Outcome;Participant;Pathway interactions;Personal Satisfaction;Pilot Projects;Population;population health;Process;Production;Program Development;programs;psychologic;Publications;recruit;Research;research data dissemination;Research Personnel;Research Support;Resources;Risk;RNA;RNA analysis;Role;Science;social;socioeconomics;stress resilience;stressor;Structure;success;Talents;Testing;transcriptome;transcriptomic profiling;transcriptomics;trend;Universities;Validation;Work

PROJECT_TITLE: USC/UCLA Center for Biodemography and Population Health: Core B


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biotechnology;Clinical Research;Genetics;Human Genome;Social Determinants of Health

PI_NAMEs: COHEN, PINCHAS  (contact)

PROJECT_TERMS: Address;Aging;Area;biodemography;Biological;Biological Assay;Biological Markers;Biological Process;biomarker panel;Blood;Calibration;circulating biomarkers;Clinic;Clinical;cohort;Collaborations;Collection;Communities;Data;Data Analyses;Data Collection;Data Linkages;data resource;Databases;Development;DNA;DNA Methylation;Dryness;Educational Activities;Educational workshop;epidemiology study;Epigenetic Process;Equipment;field study;functional genomics;Funding;Gene Expression;genome-wide;genomic data;Genomics;Goals;Hair;Health;Human;Human Resources;Hydrocortisone;improved;Information Dissemination;Infrastructure;innovation;Knowledge;Laboratories;laptop;Leadership;Link;Measurement;meetings;Methodology;Methods;Molecular Genetics;Neurosecretory Systems;non-genomic;Pathway interactions;Physiological;Physiology;Play;Population;population based;population health;Population Study;population survey;portability;Positioning Attribute;Protocols documentation;repository;Research;research data dissemination;Research Design;Research Methodology;Research Personnel;Resources;response;RNA;Role;Sampling;sequencing platform;Services;social factors;Specimen;Spottings;Standardization;success;Surveys;System;Technical Expertise;Time;Training;Training and Education;transcriptome;transcriptomics;Update;Validation;validation studies;Validity and Reliability;web site;Work;Writing

PROJECT_TITLE: USC/UCLA Center on Biodemography and Population Health: Core D


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: PROJECT NARRATIVE The protective effect of education against Alzheimer’s disease and related dementias (ADRD) is found to be smaller for racial/ethnic minority groups than non-Hispanic White individuals. To identify sociodemographic factors that mediate or modify the education-ADRD risk relationship and ultimately reduce racial/ethnic disparities in ADRD, the proposed research will conduct novel multigenerational and multilevel mediation analyses to assess the effects of education across multiple generations in a family and the effects of structural inequality and racism on ADRD risk among racial/ethnic groups. The proposed study is relevant to public health because the results will help identify socioeconomic mediators and modifiers to reduce disparities in ADRD. This study will also contribute multidomain contextual data to a nationally presentative longitudinal study.

PI_NAMEs: LUO, LIYING  (contact)

PROGRAM_OFFICER_NAME: KARRAKER, AMELIA WILKES

PROJECT_TERMS: Address;Adult Children;Affect;Alzheimer's disease related dementia;Baby Booms;Biosocial;Birth;Black Populations;Characteristics;Child;cohort;Cohort Analysis;college;contextual factors;County;Data;Data Set;Data Sources;dementia risk;Disadvantaged;Disparity;disparity reduction;Education;Educational Assessment;educationally disadvantaged;ethnic difference;ethnic disparity;ethnic minority population;Ethnic Population;Exposure to;Family;Family member;Future;Generations;Goals;Health and Retirement Study;health data;Hispanic Populations;Impaired cognition;improved;Individual;Inequality;innovation;insight;intergenerational;Longitudinal Studies;Measures;Mediating;Mediation;Mediator;Methodology;Not Hispanic or Latino;novel;novel strategies;Parents;Pathway interactions;Pattern;Population;population health;Population Process;protective effect;Public Health;racial difference;racial disparity;racial minority;racial minority population;racial population;racism;Research;Research Design;Research Personnel;Resources;Respondent;Risk Factors;Role;Schools;Social Environment;sociodemographic disparity;sociodemographic factors;socioeconomics;supportive environment;Time;tool

PROJECT_TITLE: Heterogeneous Effects of Education on Alzheimers Disease and Related Dementia among Demographic Groups: A Multigenerational and Multilevel Study


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Dental, Oral, and Craniofacial Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: Project Narrative The goal of this training program is to prepare individuals of outstanding potential for independent research careers in dental, oral and craniofacial research. Training of these individuals is critical to the health and quality of life of the American public.

PI_NAMEs: MINA, MINA  (contact)

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: Address;Area;behavioral and social science;Bioinformatics;Biology;Biotechnology;Cancer Biology;career development;Clinical;Clinical Research;Collaborations;Computational Biology;craniofacial;Dedications;Dental;Dental Schools;Doctor of Philosophy;embryonic stem cell;Enrollment;Ensure;Environment;Evolution;experience;Faculty;flexibility;Foundations;Funding;Genomic medicine;Government;Grant;Health;Imaging Techniques;Immunology;Individual;Industry;Institution;Interdisciplinary Study;Interview;Laboratories;materials science;mathematical model;Medicine;Mesenchymal Stem Cells;microbiome;Mucous Membrane;next generation;Oral;oral biology;patient oriented research;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;Process;Productivity;programs;recruit;Regenerative Medicine;Research;research and development;Research Training;Science;Scientist;skeletal;Social Sciences;Solid;Students;symposium;The Jackson Laboratory;Training;Training Programs;Training Support;Underrepresented Minority

PROJECT_TITLE: Skeletal, Craniofacial and Oral Biology Training Grant


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative Our community is in need of better preventive measures, more accurate diagnostics and more effective and efficient therapies. We offer a novel and comprehensive mechanism to address this need through research and education. We propose to create a mutually learning ecosystem that coalesce a myriad of requisite stakeholders including health systems, research enterprises and the community in southeast Wisconsin to work in tandem towards solutions that improve the health outcomes of our citizens.

PI_NAMEs: SHAKER, REZA NONE (contact)

PROGRAM_OFFICER_NAME: DIBELLO, ANTHONY THOMAS

PROJECT_TERMS: Acceleration;accurate diagnostics;Address;Affect;Age;Childhood;Clinical;Clinical and Translational Science Awards;Clinical Investigator;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communities;Community Health;Development;Diagnostic;Ecosystem;Education;Effectiveness;Elderly;Engineering;Enrollment;Ensure;Environment;Evaluation;Evolution;experience;Faculty;Fostering;Friends;Goals;Health;Health system;Healthcare;improved;Industrialization;Informatics;Infrastructure;infrastructure development;innovation;Institution;Knowledge;Lateral;Lead;Learning;life span;Measures;member;Methods;Mission;Modeling;mutual learning;National Center for Advancing Translational Sciences;next generation;novel;Outcome;outreach;Patient Care;Patients;Performance;Population;Preventive measure;Process;Program Development;programs;Research;Research Infrastructure;Research Personnel;Research Training;Science;Scientific Inquiry;Scientist;Services;Shapes;Site;Special Population;success;System;Textiles;Therapeutic;Training;Translation Process;Translational Research;translational scientist;translational study;Translations;Underrepresented Populations;underserved community;United States National Institutes of Health;Vision;Wisconsin;Work;Workforce Development


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Aging;Arthritis;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Osteoarthritis;Pain Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BIRMINGHAM

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Diet Interventions, by Race, Evaluated as Complementary Treatments for Pain (DIRECTPain) Project Narrative Racial disparities in knee osteoarthritis (OA) pain may be reduced through adoption of a demonstrated pain- reducing, low-carbohydrate diet (LCD). The overall aim of this study is to examine the efficacy of the LCD to reduce evoked pain and to determine the contribution of race to these effects, with an emphasis on psychosocial variables. We believe that the reduction in evoked and self-reported knee OA pain will be modulated by race, wherein Non-Hispanic Black individuals will experience greater benefit from the LCD, providing an alternative to opioids for pain relief and reducing racial disparities in knee OA.

PI_NAMEs: GOODIN, BUREL R.;SORGE, ROBERT  (contact)

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: Address;Adherence;Adoption;Adult;Analgesics;Arthritis;Behavior Therapy;Biological;biopsychosocial factor;Black Populations;Blood;Body Composition;Body Weight decreased;carbohydrate metabolism;Carbohydrates;chronic painful condition;Clinical;Complementary therapies;Coupled;daily pain;Degenerative polyarthritis;Diet;Dietary Intervention;disability;Disparity;Dual-Energy X-Ray Absorptiometry;efficacious treatment;efficacy evaluation;efficacy testing;experience;Female;food insecurity;Fright;Future;Human Resources;improved;Inflammation;Inflammatory;insulin sensitivity;Intervention Studies;Knee Osteoarthritis;knee pain;Knowledge;Leptin;male;Measurement;Measures;Mental Depression;Metabolic Diseases;Metabolism;Mission;Moods;National Institute on Minority Health and Health Disparities;non-opioid analgesic;Not Hispanic or Latino;Nutritional;Obesity;Opioid;osteoarthritis pain;Outcome;Oxidative Stress;Pain;Pain intensity;Pain interference;Pain management;Pain Measurement;pain reduction;pain relief;pain sensitivity;pain-related disability;Participant;Patient Self-Report;Phase;Physiological;Populations at Risk;Protocols documentation;Psychosocial Factor;Publishing;Quality of life;Race;racial difference;racial disparity;Randomized;recruit;Reducing diet;Reporting;response;Risk;Risk Factors;Running;Scanning;Severities;social;Socioeconomic Status;Testing;Time;United States Department of Agriculture;Visceral fat;Work

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Major biomedical advances for prevention and treatment, which have enabled substantial progress towards the goal of ending the HIV epidemic, will not reach their full potential without rigorous behavioral and social science research to optimize uptake, adherence, and effective and equitable implementation and scale-up. Ending the epidemic requires significant commitment of resources and effort, including further biomedical and behavioral research, and a continual infusion of an adequately trained workforce. By providing postdoctoral research training opportunities in HIV-related behavioral and social sciences, our Program will contribute to the development of the next generation of outstanding behavioral sciences HIV researchers, capable of addressing the challenges and opportunities that the evolving HIV pandemic poses.

PI_NAMEs: MELLINS, CLAUDE ANN (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TITLE: Behavioral Sciences Research in HIV Infection


ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The enclosed project aims to develop new therapeutic approaches for the fatal disorder, Niemann-Pick Type C. We will investigate the role of endogenous peptides as modulators of a newly identified receptor that can regulate cholesterol level as a means to develop treatments for this devastating disease.

PI_NAMEs: AAKALU, VINAY ;COLOGNA, STEPHANIE M (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Address;Affect;Anti-Bacterial Agents;anti-fungal agents;autosome;Biochemical;Biochemistry;Biological Markers;burden of illness;Cell Culture Techniques;Cell model;cell type;Cells;Central Nervous System;Cholesterol;cholesterol trafficking;Chronic;Clinical;clinical phenotype;Data;Defect;Diagnosis;Disease;disease phenotype;DNA Sequence Alteration;Dose;Drug Design;Drug Kinetics;drug metabolism;efficacy study;emerging adult;Epithelium;Exhibits;extend lifespan;FDA approved;Fibroblasts;Foundations;Functional disorder;Gangliosides;Genes;Genetic;Genetic Models;histatin 1;histidine-rich proteins;Human;immunogenicity;immunoregulation;Impairment;In Vitro;in vivo;life span;Ligands;Lipids;Liver;Lysosomes;Mass Spectrum Analysis;Measures;Methods;Modeling;Molecular Biology Techniques;mouse model;Mus;mutant;Mutation;Nature;Neimann-Pick's Disease Type C;Nerve Degeneration;neuronal survival;Neurons;Niemann-Pick Diseases;novel strategies;novel therapeutic intervention;novel therapeutics;NPC1 gene;Pathway interactions;patient population;Patients;Peptides;Peripheral;pharmacokinetics and pharmacodynamics;pharmacologic;Phenotype;Point Mutation;polypeptide;Positioning Attribute;Predisposition;Protein Family;Proteins;prototype;receptor;reduce symptoms;Regulation;Reporting;Role;sigma-2 receptor;Splenomegaly;Testing;Therapeutic;Translating;Treatment Effectiveness;treatment strategy;Work

PROJECT_TITLE: Novel Therapeutic Approaches for NPC Disease

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: LOS ANGELES

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Narrative Transcription of RNAs that do not encode protein, but nonetheless function in critical roles during cell division, is linked to age-related diseases including cancers. The proposed research aims to discover novel mechanisms in genomic stability by the RNA interference pathway, mediated by pericentromeric noncoding RNA in mouse stem cells. The results will inform fundamental understanding of new mechanisms of gene regulation and genomic stability critical to human development and disease, and potentially useful to develop new disease therapies.

PI_NAMEs: ZAMUDIO, JESSE R. (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Affect;age-related disease;Aneuploidy;Binding;Biological;Biological Assay;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;Cell division;Cells;Centromere;Chromatin;chromatin immunoprecipitation;Chromosomal Rearrangement;CRISPR/Cas technology;daughter cell;Defect;Development;Disease;DNA biosynthesis;Ensure;epigenome;experimental study;FBXW7 gene;Fission Yeast;Future;Gene Expression Regulation;Gene Silencing;Gene Silencing Pathway;Genetic Transcription;Genome;Genome Stability;Genomic Instability;genomic signature;Health;Heterochromatin;Homeostasis;Human;Human Development;human disease;improved;innovation;insight;Knowledge;Link;Maintenance;Malignant Neoplasms;Mammalian Cell;mammalian genome;Mammals;Maps;Mediating;Mitosis;Mitotic;Mitotic spindle;Molecular;mouse development;Mouse Embryonic Stem Cells;mouse model;Mus;mutant;Mutation;Northern Blotting;novel;overexpression;Pathway interactions;posttranscriptional;prevent;Protein Region;Proteins;recruit;Regulation;Reporter;Research;Research Project Grants;Risk Factors;RNA;RNA Binding;RNA Interference;RNA Interference Pathway;RNA Stability;Role;S phase;Small RNA;stem cells;Structure;System;Testing;tool;tumorigenesis;Untranslated RNA

PROJECT_TITLE: Mechanisms of Genomic Stability by Mammalian Argonaute Proteins

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Sexually Transmitted Infections;Urologic Diseases;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Rates of sexually transmitted infections with Neisseria gonorrhoeae are rising in the US and increasing gonococcal antibiotic resistance presents a major public health threat. Inadequate understanding of the natural history of infection is a substantial impediment to the development of public health interventions against gonorrhea, particularly vaccines. This study proposes a novel longitudinal study of N. gonorrhoeae natural history in a high-risk cohort to identify the bacterial and host determinants of infection outcome using the distinct, yet integrated, strategies of pathogen and natural microbial community genomics and immunology.

PI_NAMEs: DUNCAN, JOSEPH A (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Anatomy;Antibiotic Resistance;Antibiotic Therapy;Antibodies;Antibody Response;Antigenic Variation;Antigens;Area;Bacteria;bactericide;Bioinformatics;Biological;Biological Factors;cervicovaginal;Characteristics;clinical care;Clinical Trials;Clone Cells;cohort;Collaborations;Communities;Data;Data Set;Development;Drug-resistant Neisseria Gonorrhoeae;Enrollment;Epidemiology;Female;Female genitalia;follow-up;Gene Expression Profile;Genes;Genetic;Genetic Transcription;genital microbiota;genome sequencing;Genomics;Gonococcal urethritis;Gonorrhea;high risk;high risk men;Human;Immune Evasion;Immune response;Immunity;Immunologic Factors;Immunology;Individual;Infection;infection rate;Integration Host Factors;Investigation;Lactobacillus;Longitudinal cohort study;Longitudinal Studies;Malawi;male;Male Genital Organs;men;microbial community;microbial genomics;Microbiology;microbiome;microbiome analysis;microbiota composition;Minority;Modeling;Monoclonal Antibodies;mucosal site;multidisciplinary;Multiple Anatomic Sites;multiple omics;Natural History;Neisseria gonorrhoeae;novel;Observational Study;Outcome;participant enrollment;pathogen;pathogen exposure;Pathogenesis;Periodicals;Phase;Pilot Projects;Play;Population;Public Health;public health intervention;Resistance;Resources;response;sample collection;sex;Sexual Partners;sexual risk reduction;Sexually Transmitted Diseases;Site;Specimen;T-Lymphocyte;Technology;Testing;Time;transcriptome;transcriptome sequencing;transcriptomics;transmission process;Urethritis;vaccine development;Vaccines;vaginal microbiota;Variant;whole genome;Woman

PROJECT_TITLE: Understanding pathogen and host determinants of the natural history of N. gonorrhoeae infection


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Physical Activity;Physical Rehabilitation;Rehabilitation;Rheumatoid Arthritis

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE. Disability is common in adults with rheumatoid arthritis. Rehabilitation and exercise can improve disability but are not well integrated into routine care. The proposed study is necessary to develop a model to integrate rehabilitation and exercise guidance into routine care with the goal of preserving valued activities in life for adults with rheumatoid arthritis.

PI_NAMEs: THOMA, LOUISE M. (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Acceleration;acceptability and feasibility;Address;Adult;American;Anti-Rheumatic Agents;Autoimmune Diseases;Award;Canada;career development;Caring;Clinical;clinical research site;Clinical Trials;cohort;Collection;Country;design;Development;Development Plans;disability;disability risk;Disease;Early identification;effectiveness testing;Exercise;exercise intervention;Exercise Therapy;Fatigue;feasibility testing;Feedback;follow-up;functional decline;Germany;Goals;Health Services Research;Impairment;improved;Interview;joint destruction;joint inflammation;K-Series Research Career Programs;Knowledge;Learning;Life;Measurement;Medication Management;Mentors;Methodology;Modeling;Musculoskeletal Diseases;Outcome;Pain;participant retention;Patient Recruitments;Patients;pharmacologic;Phase;Physical Exercise;physical impairment;physical therapist;Physical therapy;Pilot Projects;pilot test;pilot trial;Preparation;preservation;Process;prospective;Provider;Questionnaires;randomized trial;Recommendation;Regimen;Rehabilitation therapy;Research;Research Proposals;Rheumatism;Rheumatoid Arthritis;rheumatologist;routine care;Sampling;screening;Screening procedure;Screening Result;Specificity;Structure;Surveys;therapy development;Time;tool;Training;treatment guidelines;United States;Value of Life

PROJECT_TITLE: Helping Adults with RA PREVAIL: Developing a model to Preserve Valued Activities In Life

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Electronic Nicotine Delivery Systems;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Tobacco

ORG_CITY: BOSTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Identiﬁcation of genomic alterations at the single cell level will enrich our understanding of various mutational processes underlying diseases. The algorithms and software developed in this project will be useful to the scientiﬁc community in employing single cell approaches for DNA analysis.

PI_NAMEs: PARK, PETER J (contact)

PROGRAM_OFFICER_NAME: WELLINGTON, CHRISTOPHER

PROJECT_TERMS: age related;Algorithms;Alleles;Allelic Imbalance;autoencoder;Bar Codes;base editing;base editor;Biological;Biological Phenomena;Brain;Brain Neoplasms;cancer cell;Cell division;Cell Line;Cells;Cellular Assay;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Complex;Computing Methodologies;Copy Number Polymorphism;Data;deep learning;Detection;Development;Disease;DNA amplification;DNA analysis;DNA Repair Inhibition;DNA Sequence Alteration;DNA sequencing;driver mutation;Effectiveness;electronic cigarette use;Embryonic Development;Environment;Environmental Exposure;Environmental Impact;Event;experience;Genetic Heterogeneity;Genome;genome editing;genome sequencing;genome-wide;Graph;Heterogeneity;human tissue;improved;insertion/deletion mutation;insight;interest;Ligation;machine learning method;machine learning model;Malignant Neoplasms;Maps;Methods;Microsatellite Repeats;Modeling;Morphologic artifacts;mosaic variant;Mutation;Mutation Analysis;Neurons;Noise;off-target mutation;Pattern;Phase;Population;prime editing;prime editor;Process;Protocols documentation;rare variant;repaired;Resolution;Sampling;sequencing platform;single cell analysis;single cell ATAC-seq;Single Nucleotide Polymorphism;single-cell RNA sequencing;software development;Somatic Mutation;statistical learning;success;System;Tandem Repeat Sequences;Techniques;Tissues;tool;Trees;tumor;validation studies;vaping;Variant;whole genome;Work

PROJECT_TITLE: Development and Application of Computational Methods for Single Cell DNA Sequencing Data

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Drug resistance and disease relapse is common in patients with high-risk acute myeloid leukemia (AML). Almost 40-50 % patients die due to disease relapse. Here we provide molecular insights into the pathways exploited by AML cell to survive during drug treatment, which results in treatment resistance, and demonstrate that blocking these pathways leads to a cure. While the project focuses on AML, the findings should be readily translatable to pother treatment resistant cancers.

PI_NAMEs: AZAM, MOHAMMAD  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Alleles;Apoptotic;ATAC-seq;Binding;Biochemical;Bone marrow failure;cancer cell;Categories;Cells;Chemicals;chemotherapy;Chemotherapy-Oncologic Procedure;Chromatin;Chronic Myeloid Leukemia;clinically relevant;combinatorial;Combined Modality Therapy;Complex;Complex Analysis;Data;Dependence;dimer;Disease;Disease Outcome;Dissection;DNMT3a;Drug resistance;drug sensitivity;DUSP1 gene;Ectopic Expression;Enhancers;experimental study;Family;FLT3 gene;FLT3 inhibitor;FOS gene;Genes;Genetic;Genetic Models;Genetic Transcription;Genomics;Goals;Hematologic Neoplasms;high risk;humanized mouse;In Vitro;in vivo;inhibitor;insight;Internal Ribosome Entry Site;jun Oncogene;JUNB gene;leukemia;Leukemic Cell;leukemic transformation;Link;Malignant - descriptor;Malignant Neoplasms;Mediating;Medicine;MLL-AF9;Modeling;Molecular;Molecular Analysis;mouse genetics;mouse model;Mus;Mutate;Mutation;Nature;Normal Cell;novel;novel therapeutics;NPM1 gene;Oncogenic;overexpression;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phosphotransferases;prevent;Prognosis;Protein Tyrosine Kinase;Proteins;Publications;Recurrent disease;refractory cancer;Regulation;Reporter;Reporter Genes;Resistance;Resistance development;response;Risk;RUNX1 gene;Sampling;Signal Transduction;small molecule;targeted treatment;Testing;Therapeutic;therapeutic target;therapy outcome;therapy resistant;TP53 gene;transcription factor;Transcription Factor AP-1;transcriptome sequencing;Treatment Efficacy;Treatment Failure;treatment group;treatment response;treatment strategy;tumor;tumorigenesis;Validation;whole genome;Wild Type Mouse;Work

PROJECT_TITLE: Mechanism of Therapy in high-risk AML

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: HUGO W. MOSER RES INST KENNEDY KRIEGER

ORG_STATE: MD

PHR: Project Narrative Acute flaccid myelitis is an emerging infectious disorder caused primarily by Enterovirus D68 that resembles polio and is affecting increasing numbers of children in the Unites States and worldwide. It is poorly understood and therefore has few effective treatment options. To better define the pathophysiology of acute flaccid myelitis and evaluate therapeutic targets, I will study the infection of motor neurons by Enterovirus D68 to evaluate the role of disrupted nucleocytoplasmic transport in motor neuron toxicity, define early events in motor neuron pathology, and determine the role of host genetics in disease.

PI_NAMEs: ELRICK, MATTHEW J (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: acute flaccid myelitis;Affect;Animal Model;Biological Models;Cell Death;Cellular biology;Child;Clinical;Clinical Data;Coculture Techniques;Communicable Diseases;Complement;Data;data modeling;Development;Diagnosis;Disease;disease model;Disease Outbreaks;effective therapy;Electrophysiology (science);Enterovirus;Enterovirus 68;Enterovirus Infections;Environment;epidemiologic data;Event;experimental study;Functional disorder;Future;Genetic;Genetic Variation;Health Benefit;Human;Immune;In Vitro;Incidence;induced pluripotent stem cell;Infection;Injury;insight;Integration Host Factors;Knowledge;Lead;Link;Mediating;Methods;Microscopy;Modeling;Morbidity - disease rate;Morphology;Motor;motor neuron function;motor neuron injury;Motor Neurons;Muscle Fibers;Nature;Nervous System Disorder;Neurodegenerative Disorders;Neurologic Symptoms;Neuromuscular Junction;neuron loss;Neuronal Dysfunction;Neurons;neuroprotection;Neurosciences;neurotoxicity;new therapeutic target;novel;Nuclear Pore Complex;Nuclear Pore Complex Proteins;nucleocytoplasmic transport;Onset of illness;Paralysed;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Peptide Hydrolases;permissiveness;pharmacologic;Poliomyelitis;Predisposition;Prevalence;prevent;Prevention;Protease Inhibitor;protein transport;Public Health;Recovery;Recurrence;Resolution;RNA Transport;Role;Spinal;Structure;Study models;Susceptibility Gene;System;Therapeutic;therapeutic target;Training;United States;Viral;virology;Work

PROJECT_TITLE: Mechanisms of Motor Neuron Injury in Acute Flaccid Myelitis

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Cancer

ORG_CITY: ATLANTA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECTIVE NARRATIVE Significant breakthroughs in cancer diagnosis and treatment are limited by the shortage of scientists and clinicians with the necessary training to bridge the gap between basic science discovery in the lab and clinical advancement for the patient. The Emory Training Program in Cancer Biology will provide enhanced mentored training to postdoctoral fellows to acquire the depth of knowledge and critical skills in cancer biology research combined with the practical exposure and understanding of clinical concepts to initiate an impactful independent research program to make transformative discoveries to improve quality of care for patients with cancer.

PI_NAMEs: YU, DAVID SUNG-WEN (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Cancer Biology;Training Programs

PROJECT_TITLE: T32 Training Program in Cancer Biology

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: PROJECT NARRATIVE The phosphatidylinositol-5-phosphate 4-kinases (PI5P4Ks) are lipid kinases that have evolved to mediate cellular responses to stress yet how they are regulated is not understood. We have discovered that the core kinases of the Hippo pathway, MST1 and MST2 are direct negative regulators of PI5P4K activity, as well as the lipid substrate of the PI5P4Ks, PI-5-P interacts with the Hippo adaptor protein MOB1 which in turn effects the activity of the Hippo downstream effector YAP. The overall goal of this R01 proposal is to obtain a comprehensive understanding of Hippo-PI5P4K communication under physiological conditions and elucidate the oncogenic roles of the Hippo-PI5P4K axis for breast cancer development.

PI_NAMEs: EMERLING, BROOKE M (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: 1-Phosphatidylinositol 4-Kinase;Adaptor Signaling Protein;Affinity;Binding;Binding Proteins;Biological;Biophysics;Biosensor;blind;Breast;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;breast tumorigenesis;Cancer Biology;cancer cell;Cancer Cell Growth;cancer therapy;cell growth;Cell Line;Cell model;Cells;Cellular biology;Collaborations;Communication;Complex;Data;Development;druggable target;Event;Family;Future;Genetic;genetic approach;Genetic Transcription;Goals;Growth;Homeostasis;Human;Impairment;In Vitro;in vivo;Link;Lipids;Malignant Breast Neoplasm;Malignant Neoplasms;Mammalian Cell;Mammalian Genetics;Mammary Neoplasms;Mediating;Metabolic;Metabolism;Molecular;Mus;nanomolar;Neoplasm Metastasis;novel;Nutrient availability;Oncogenic;Organogenesis;Output;Pathologic;Pathway interactions;Patients;phosphatidylinositol 5-phosphate;phosphatidylinositol phosphate 4-kinase;Phosphatidylinositols;Phosphorylation;Phosphotransferases;Physiological;preservation;Property;protein expression;Proteins;Publishing;Regulation;Resolution;response;Role;Sampling;Signal Pathway;Signal Transduction;Specimen;Stress;structural biology;Structure;Techniques;Transcriptional Activation;triple-negative invasive breast carcinoma;tumor growth;tumor progression;tumorigenic;Work

PROJECT_TITLE: Function and Mechanism of the Hippo-PI5P4K Axis for Growth Control

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-C(02)M]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Services

PHR: PROJECT NARRATIVE This research will provide evidence on whether private Medicare plans can improve health outcomes for older adults. The findings from this project will also contribute to an understanding of the mechanisms that private Medicare plans can use that benefit or harm high-risk patients. This work will inform better public policy and regulation for the Medicare program, which has the potential to enhance health, lengthen life, and reduce illness for millions of Americans.

PI_NAMEs: CURTO, VILSA ELIANA (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Address;adverse outcome;American;Area;Asthma;Award;Cardiovascular Diseases;care coordination;care outcomes;career;Caring;Characteristics;Chronic;Clinical;Clinical Management;Comprehensive Health Care;Cost Control;Cost Savings;Country;County;Data;Databases;Diabetes Mellitus;Economic Policy;Enrollment;Face;Fee-for-Service Plans;Fee-for-Service Reimbursements;financial incentive;Goals;Health;Health Care Costs;health care quality;health economics;Health Insurance;Health Personnel;health plan;Health Policy;Health Status;Healthcare Systems;high risk;improved;improved outcome;Institution;Insurance;Insurance Benefits;Insurance Carriers;K-Series Research Career Programs;Knowledge acquisition;Learning;Life;Managed Care Programs;Marketing;Massachusetts;Measurement;Measures;Medicare;member;Mentorship;Methods;Modeling;Modernization;mortality;older adult;Outcome;Patient Care;Patient Selection;patient subsets;Patient-Focused Outcomes;Patients;payment;Performance;Persons;Preventive care;Preventive service;Privatization;Productivity;programs;Provider;provider networks;public health insurance;Public Policy;Quality of Care;Quasi-experiment;readmission rates;Regulation;Research;Research Personnel;Research Support;Risk Adjustment;Services;skills;Special needs plan;Specialist;Statistical Methods;System;Training;United States;Variant;Work

PROJECT_TITLE: Private Medicare Plans and Health Outcomes for Older Adults

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE This project aims to develop a real-time precision opto-control (RPOC) technology for selective control of all biomolecules of interest in live cells using lasers. We will prototype a high-speed ‘smart’ RPOC platform that manipulates biomolecules based on optical logic signals and demonstrate the capability of this platform by designing photoswitchable compounds for controlling enzyme activities at sub-micron precision. Then, we will build a multi-color portable RPOC system for broader applications outside an optical laboratory.

PI_NAMEs: ZHANG, CHI  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TITLE: Chemical-selective real-time laser precision control of biomolecules


ORG_CITY: WACO

ORG_NAME: BAYLOR UNIVERSITY

ORG_STATE: TX

PHR: Project Narrative The efficient preparation of small molecule therapeutics is contingent upon the availability and diversity of chemical tools. Moreover, the synthesis of pharmaceutically relevant chiral molecules presents an even greater synthetic challenge if isomerically pure compound is necessary in order to minimize potential off-target biological effects. The goals of this proposal aim to develop new chemical tools for the highly selective upgrading of hydrocarbon feedstocks to value-added chemical building blocks, further abridging synthetic sequences and improving access to drug-like molecules.

PI_NAMEs: ROMERO, LIELA  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Acceleration;Address;Area;base;Biological;Catalysis;catalyst;chemical addition;chemical synthesis;Chemicals;chiral molecule;Development;drug development;drug discovery;drug-like compound;Generations;Goals;halogenation;Hydrocarbons;Imaging Techniques;Improve Access;innovation;Isomerism;Methodology;novel strategies;Pharmaceutical Preparations;Preparation;Process;programs;Reagent;Research;small molecule therapeutics;Source;Technology;tool;Work

PROJECT_TITLE: New Catalytic Stereoselective Strategies for Hydrocarbon Functionalization Via Ionic Intermediates

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Aging;Brain Disorders;Digestive Diseases;Genetics;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

ORG_STATE: MI

PHR: The proposed research is relevant to the missions of the NIH and NINDS because it determines mechanisms involved in the initiation and progression of Parkinson's disease. This work will identify molecular factors in the vermiform appendix that are abnormal in Parkinson's disease cases to further our understanding of gastrointestinal contributions to Parkinson's disease. In the long-term, this work can advance the development of new tools for early diagnosis and therapeutic interventions for patients with this devastating condition.

PI_NAMEs: BRUNDIN, LENA CECILIA (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Advanced Development;Affect;Age;alpha synuclein;Anatomy;Autophagocytosis;Biochemical;Biological;Biological Assay;Brain;Brain Diseases;Brain Pathology;comparison control;Data;Development;Digestive System Disorders;disease diagnostic;DNA Methylation;dopaminergic neuron;Early Diagnosis;Enteral;epidemiology study;Epigenetic Process;epigenetic profiling;Etiology;Excision;Exhibits;Experimental Models;experimental study;Functional disorder;gastrointestinal;Gastrointestinal tract structure;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;genome-wide;Goals;gut inflammation;Human;in vivo;Individual;innovation;insight;Lewy Bodies;Maps;Mass Spectrum Analysis;Mission;Molecular;Molecular Profiling;motor disorder;motor symptom;Mus;National Institute of Neurological Disorders and Stroke;Nerve;Nerve Degeneration;Neurodegenerative Disorders;Neurons;neuropathology;nigrostriatal system;non-motor symptom;Onset of illness;Parkinson Disease;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway Analysis;Pathway interactions;Patients;Phase;pre-formed fibril;predictive marker;Process;programmed cell death protein 1;Proteins;Research;Resources;Risk;Shapes;Source;Substantia nigra structure;synucleinopathy;System;Testing;Therapeutic Intervention;therapy development;Tissues;tool;transcriptomics;United States National Institutes of Health;Wild Type Mouse;Work

PROJECT_TITLE: The contribution of the vermiform appendix to Parkinson's disease

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: The proposed research is relevant to public health because providing a means of continuous hemodialysis is important for clinical outcomes by enabling more flexible hemodialysis prescriptions. The project will develop a robust, ultrathin, sheet-membrane hemodialyzer suitable for continuous hemodialysis using a two-filter system that will be tested on the benchtop and in a small animal model. The silicon nitride-based dialyzer will be scalable to clinical use and supports the “Advancing American Kidney Health initiative”.

PI_NAMEs: JOHNSON, DEAN G (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: Address;Adoption;Albumins;American;Animal Model;Animals;Area;Arteries;Artificial Kidney;beta-2 Microglobulin;Binding Proteins;Blood;Blood flow;Blood Platelets;Blood Pressure;Blood Vessels;Cardiovascular system;Cell Adhesion;Cells;Clinical;Coagulation Process;Complement Activation;cost;Cresol;design;detection assay;detection limit;Devices;Dialysis procedure;Diffusion;End stage renal failure;Excision;experimental study;Female;Filtration;flexibility;Floor;Generations;Health;Health Care Costs;Heart Rate;Height;hemocompatibility;Hemodialysis;Hemolysis;Homeostasis;Hour;Human;Implant;improved;Infusion procedures;Injections;instrument;Kidney;Life Style;Lifting;male;Measures;Mechanics;Membrane;Metabolic;Metabolic Clearance Rate;Modeling;Molecular;nano;nanomembrane;Nanoporous;novel;operation;Outcome;Patients;Physics;Plasma;portability;Preparation;pressure;prevent;programs;Proteins;Public Health;Quality of life;Rattus;Research;Risk;Sampling;Series;Silicon;silicon nitride;Sprague-Dawley Rats;System;Techniques;Technology;Testing;Thinness;Time;Toxin;treatment duration;Treatment Protocols;Ultrafiltration;Urea;Uremia;Water;wearable device;Weight;Whole Blood

PROJECT_TITLE: Novel Sheet-Membrane Dialyzer for Wearable Hemodialysis

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Infectious Diseases;Microbiome

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Little is known about the core ocular microbiome constituents in a healthy population. This project will characterize the ocular microbiome at the species level and their interactions with the immune system using well-established whole-metagenome sequencing, and metatranscriptomics methods optimized for low-biomass clinical samples. The outcomes of this study will add to our understanding of the core microbial constituents in anterior segment and their role in immune interactions to maintain homeostasis.

PI_NAMEs: GANGAPUTRA, SAPNA S;RAJAGOPALA, SEESANDRA VENKATAPPA (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Acinetobacter;Adult;age group;analytical tool;Anterior;anterior chamber;Anterior eyeball segment structure;Bacteria;bacteria classification;Biological;Biomass;Bradyrhizobium;Clinical;cohort;Collaborations;conjunctiva;Corynebacterium;cost effective;Culture Media;Data;Disease;Environment;Epithelium;Exposure to;eye chamber;fungus;Gene Expression Profile;Genetic Markers;Genetic Transcription;Genus staphylococcus;Homeostasis;Human;Human body;Human Microbiome;Immune;Immune response;Immune system;immunoregulation;Inferior;Knowledge;metagenome;metagenomic sequencing;Metagenomics;metatranscriptome;metatranscriptomics;Methods;Methylobacterium;Microbe;microbial;microbial community;microbiome;microorganism;middle age;Molecular;Mucous Membrane;multidisciplinary;next generation sequencing;novel;ocular microbiome;ocular surface;older adult;Ophthalmology;Outcome Study;Pathway interactions;Population;Propionibacterium;prospective;Pseudomonas;Publishing;Research Personnel;Ribosomal RNA;Role;sample collection;Sampling;Seasons;Sex Differences;Skin;Sphingomonas;Streptococcus;Structure;Swab;Taxon;Virus;young adult

PROJECT_TITLE: Molecular characterization of the ocular microbiome in healthy adults


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Genetics;Infectious Diseases;Machine Learning and Artificial Intelligence

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: PROJECT NARRATIVE Fungal infections are common, increasing in frequency and severity, and cause considerable morbidity and mortality. Early recognition of invasive fungal infection, and prompt initiation of effective antifungal therapy, are key to improving patient outcomes. This proposal aims to adapt a novel paradigm for rapid pathogen identification and antimicrobial susceptibility testing through the quantitative detection of RNA signatures to transform fungal diagnostics.

PI_NAMEs: BHATTACHARYYA, ROBY PAUL (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Address;Advanced Development;anti-fungal agents;Anti-microbial susceptibility;Antibiotics;Antifungal Therapy;antimicrobial;Aspergillus;Azoles;Bacteria;Bacterial Infections;Bacterial RNA;Biological Assay;Biopsy Specimen;Blood;Bronchoalveolar Lavage;Candida;Candida auris;candidate selection;Cells;Cessation of life;Class Zygomycetes;Classification;Clinical;Clinical Management;Clinical Microbiology;clinically significant;Collaborations;computational pipelines;Data;design;Detection;detection limit;detection platform;Diagnosis;Diagnostic;diagnostic assay;Diagnostic tests;Drug resistance;effective therapy;efflux pump;experience;Frequencies;Funding Opportunities;fungus;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genetic;Genetic Transcription;Genotype;Goals;Growth;Hour;Human;improved;machine learning algorithm;Measures;Medical;Medicine;Messenger RNA;Methods;microbial;Modeling;Morbidity - disease rate;mortality;Multi-Drug Resistance;Mycoses;nano-string;Nature;novel;novel strategies;overexpression;pathogen;pathogenic fungus;patient population;Patient-Focused Outcomes;Patients;Pattern;Performance;personalized diagnostics;Phenotype;Phylogenetic Analysis;Polyenes;Positioning Attribute;Predisposition;Prevalence;prophylactic;Public Health;random forest;rapid test;Reporting;Resistance;resistance mechanism;response;Ribosomal RNA;RNA;RNA Sequences;RNA, Ribosomal, 28S;Sampling;Severities;Skin;Specimen;Speed;Sputum;Swab;Symptoms;Taxonomy;Test Result;Testing;Time;Toxic effect;Transcript;transcriptome sequencing;transcriptomics;treatment response;Urine;Work

PROJECT_TITLE: Rapid fungal identification and antifungal susceptibility testing through quantitative, multiplexed RNA detection

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Kidney Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: HARVARD UNIVERSITY

PHR: PROJECT NARRATIVE The development of engineered, patient-specific kidney tissue would meet an urgent clinical need for ~110,00 patients awaiting renal replacement therapy and also serve as a model platform to expedite biomedical research. While significant progress has been made towards this goal, engineered kidney tissue still lacks a collecting duct network and ureter. This proposal will result in the development of an engineered collecting duct network with a single drainage outlet that would enable filtrate removal from engineered kidney tissues.

PI_NAMEs: WOLF, KAYLA  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: 3-Dimensional;Automobile Driving;Biocompatible Materials;biofabrication;Biological Assay;Biological Models;Biomedical Engineering;Biomedical Research;bioprinting;career;career development;Carrier Proteins;Cell Culture Techniques;Cells;Clinical;Collagen;Communication;Coupled;Data Analyses;design;Development;Development Plans;differentiation protocol;disease model;Distal;Doctor of Philosophy;Drainage procedure;Drug Screening;Duct (organ) structure;Engineering;Environment;Epithelium;Excision;Experimental Designs;Extracellular Matrix;fabrication;Fellowship;Filtration;First Pregnancy Trimester;Gene Expression;Genes;Goals;Human;human embryonic stem cell;Human Engineering;human induced pluripotent stem cells;human pluripotent stem cell;In Vitro;insight;interstitial;Kidney;Knowledge;Mentorship;Mesenchyme;Metanephric Diverticulum;Methodology;Methods;Modeling;Morphogenesis;Morphology;Nephrons;network models;Organoids;patient derived induced pluripotent stem cells;Patients;Pattern;Phenotype;Physiology;Play;Porosity;post-doctoral training;programs;protein expression;protein function;Protocols documentation;Renal Replacement Therapy;Research;research and development;Research Personnel;response;responsible research conduct;Role;scaffold;skills;stem cells;System;Techniques;Testing;Tissue Engineering;Tissues;tool;Training;Tubular formation;United States National Institutes of Health;Universities;Ureter;Work

PROJECT_TITLE: Engineering scalable collecting duct networks for functional kidney tissue


NIH_SPENDING_CATS: Aging;Atherosclerosis;Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Prevention

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative A polygenic score detects 20% of the population with more than double the average risk of heart attacks caused by coronary plaque, and those are flying under the radar in current clinical practice. This project will return a high polygenic score result to 300 participants of a hospital biobank, study how their cardiovascular health and blood biomarkers contribute to their coronary plaque imaged using a dedicated coronary CT scan, and finally conduct a clinical trial on half of them to determine whether and how colchicine combined with statin changes their coronary plaque over a one-year period.

PI_NAMEs: FAHED, AKL C (contact);LU, MICHAEL TSE-YIN

PROGRAM_OFFICER_NAME: FLEG, JEROME L

PROJECT_TERMS: Address;Affect;American Heart Association;Anti-Inflammatory Agents;Atherosclerosis;Attenuated;attenuation;biobank;Biological Markers;Blood;Blood Vessels;C-reactive protein;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Clinic;Clinical;clinical practice;clinical risk;Clinical Trials;cohort;Colchicine;Combined Modality Therapy;Coronary;Coronary Arteriosclerosis;coronary computed tomography angiography;coronary plaque;Data;Dedications;Development;Disclosure;DNA;Dose;Double-Blind Method;Event;Family;Fatty acid glycerol esters;Flying body movement;Genetic Predisposition to Disease;genome-wide;Genomic medicine;Health education;Health system;high risk;Hospitals;Image;implementation study;indexing;Individual;Inflammation;Inflammatory;innovation;interest;Interleukin-1 beta;Interleukin-6;Intervention;Investigation;LDL Cholesterol Lipoproteins;Life;Lipids;Longitudinal Studies;Low-Density Lipoproteins;Matched Group;Measures;middle age;Myocardial Infarction;Participant;Pathway interactions;Patients;Persons;pharmacologic;Pharmacological Treatment;Phenotype;Pilot Projects;polygenic risk score;Population;prevent;Primary Care;primary endpoint;prospective;Protocols documentation;Randomized;randomized trial;Recording of previous events;Recurrence;Risk;Risk Factors;Risk Reduction;rosuvastatin;Rupture;Site;Target Populations;Testing;treatment group;Variant;X-Ray Computed Tomography

PROJECT_TITLE: Coronary plaque changes with statin and colchicine among people with high polygenic risk- a mechanistic pilot study

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Sexually Transmitted Infections;Social Determinants of Health

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: Narrative The proposed research focuses on developing and testing a web-based platform, called Jom-TestPlus, that will incorporate HIV self-testing (HIVST) with real-time e-counseling (eHIVST) with online-to-offline (O2O) linkage to HIV prevention and treatment services while simultaneously co-addressing chemsex-related needs for men who have sex with men (MSM) in Malaysia. This model represents a potentially impactful strategy for reaching marginalized populations, like MSM, and allows immediate engagement in the post-test linkage process to prevention or treatment services.

PI_NAMEs: SHRESTHA, ROMAN  (contact);WICKERSHAM, JEFFREY ALLEN

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: Acceleration;acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;AIDS prevention;Amphetamines;antiretroviral therapy;Attitude;Capital;Caring;Cellular Phone;Clinic;clinical care;Collaborations;Communication;Communications Media;Communities;Continuity of Patient Care;cost effective;Counseling;Country;Development;Diagnostic Reagent Kits;Discrimination;distrust;Drug usage;eHealth;empowerment;Environment;Epidemic;experience;Face;Focus Groups;Fostering;Fright;Guidelines;Harm Reduction;Health;Health care facility;Health Personnel;Health Technology;high risk;high risk behavior;high risk men;HIV;HIV/STD;Homosexuality;Hour;Human immunodeficiency virus test;Hybrids;implementation context;implementation determinants;implementation science;improved;Incidence;Income;Individual;innovation;insight;Intervention;Knowledge;laptop;Laws;Malaysia;Malaysian;marginalized population;Medical;men;men who have sex with men;Mental Depression;Mental disorders;Modeling;Motivation;Muslim population group;novel strategies;Online Systems;pilot test;pre-exposure prophylaxis;preference;Prevalence;prevention service;Process;Professional counselor;prototype;Psychotropic Drugs;Recommendation;Research;Risk Behaviors;scale up;self testing;service delivery;Services;sex;sexual encounter;Sexual Partners;Sexual Transmission;Sexuality;social;social stigma;stem;Stigmatization;Stimulant;substance use;syndemic;Tablets;Technology;Testing;Time;tool;transmission process;treatment as usual;treatment services;Unsafe Sex;usability;Wait Time;web platform;willingness;World Health Organization

PROJECT_TITLE: Integrated online-to-offline (O2O) model of care for HIV prevention and treatment among men who have sex with men

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Brain Disorders;Mental Health;Mental Illness;Neurosciences;Psychosis;Serious Mental Illness

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Psychosis: A Convergent Neuroscience Perspective is a training grant aiming to provide basic and clinical neuroscientists with the skills and knowledge necessary to establish an interdisciplinary research career that can contribute to understanding the neurobiology of psychosis spectrum disorders. This renewal application capitalizes on the depth of resources, facilities and faculty dedicated to research and training in translational neuroscience at the University of Pennsylvania. The program forges cross-fertilization of clinical and basic neuroscientists, with diverse expertise that is critical for probing neural mechanisms pertinent to psychosis and advancing novel treatments.

PI_NAMEs: GUR, RAQUEL E (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Neurosciences;Psychoses


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Cerebrovascular;Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Stroke;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because no effective therapeutic intervention currently exists beyond, physical, occupational and speech therapy for the hundreds of thousands of individuals who live with motor and cognitive disabilities following traumatic brain injury. The goal of the research is to develop a deep brain stimulation system that will facilitate post-injury recovery of motor and cognitive function sufficient to improve daily function and vocational reentry. The project is relevant to the mission of the National Institutes of Neurological Disorders and Stroke as we are seeking to reduce the burden of traumatic brain injury on individuals, their families, and society.

PI_NAMEs: BAKER, KENNETH B (contact);MACHADO, ANDRE GUELMAN

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Acute;Animals;Anxiety;Area;Basal Ganglia;Behavioral;BRAIN initiative;Brain Injuries;Cerebellar Nuclei;Cerebral cortex;Chronic;Cognitive;Cognitive deficits;cognitive disability;cognitive enhancement;cognitive function;cognitive recovery;Contralateral;controlled cortical impact;daily functioning;Data;Deep Brain Stimulation;Dentate nucleus;design;Electric Stimulation;Experimental Designs;Family;fluid percussion injury;Frequencies;frontal lobe;functional improvement;Future;Glutamates;Goals;Homologous Gene;Human;improved;Individual;Infarction;Injury;injury recovery;insight;Intervention;Ischemia;Ischemic Stroke;Lateral;Learning;Lesion;Link;Long term disability;Long-Term Potentiation;Magnetic Resonance Imaging;Manganese;Maps;Medial;Mediating;Memory;microstimulation;middle cerebral artery;Mission;Modeling;Molecular;Motor;Motor Activity;motor deficit;Motor disability;motor recovery;motor rehabilitation;National Institute of Neurological Disorders and Stroke;Nature;neurological recovery;novel strategies;novel therapeutic intervention;Occupational Therapy;Outcome;Parietal Lobe;Pathway interactions;Patients;Pattern;Phase I Clinical Trials;Physical therapy;Physiological;Physiological Processes;post stroke;pre-clinical;Prefrontal Cortex;primary outcome;Process;Public Health;Quality of life;Rattus;Recovery;Rehabilitation therapy;Research;response;Rodent;Rodent Model;Role;Secondary to;Severities;Societies;spatial memory;Speech Therapy;Stroke;stroke patient;Survivors;synaptogenesis;System;Thalamic structure;Therapeutic;Therapeutic Intervention;therapeutically effective;Time;Tissue Sample;Tissues;Translating;Translations;Traumatic Brain Injury;United States;United States National Institutes of Health;Vocation;With laterality;Work

PROJECT_TITLE: Deep Brain Stimulation of the Cerebellar Dentate Nucleus to Enhance Chronic, Post-Traumatic Brain Injury Rehabilitation

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]