NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention

ORG_CITY: WESTPORT

ORG_NAME: ALARA IMAGING INC.

ORG_STATE: CT

PHR: Project Narrative A quality gap exists in the performance of computed tomography (CT) as radiation doses are higher than needed for diagnosis and vary depending on where a patient goes for care. Alara Imaging has developed patient safety measures that are focused on the radiation dose and image quality for CT and are being considered for use in the Centers for Medicare and Medicaid Services (CMS) quality payment programs; the use of these measures has the potential to reduce the doses used for CT to make CT safer. Alara Imaging is seeking funding to support the development of commercially built software that hospitals and physicians can use to report on these measures as well as seeking funding to build software to help guide physicians to lower the doses they use for CT.

PI_NAMEs: MAZONSON, NATHAN  (contact)

PROGRAM_OFFICER_NAME: TRIPURANI, SWAMY KRISHNA

PROJECT_TERMS: Adoption;Architecture;Automobile Driving;Award;Benchmarking;California;cancer diagnosis;cancer risk;Caring;Categories;Certification;Clinical;Clinical Data;Clinical/Radiologic;Collaborations;Communication;comparative;Computer software;Computer Vision Systems;Data;data access;data management;data visualization;Development;Diagnosis;Digital Imaging and Communications in Medicine;Dose;electronic health data;Electronic Health Record;Electronics;Equity;Fast Healthcare Interoperability Resources;Feedback;financial incentive;firewall;Funding;Graph;Health;health disparity;Health Insurance Portability and Accountability Act;Health Status;Healthcare Systems;Hospitals;Image;imaging facilities;imaging software;Informatics;Information Systems;Information Technology;Ingestion;Inpatients;Intellectual Property;Interview;Link;Machine Learning;Malignant Neoplasms;Measures;Medical Imaging;Minority;Modernization;novel;Outpatients;Patient imaging;patient safety;Patients;payment;peer;Performance;Persons;Physicians;Picture Archiving and Communication System;prevent;programs;Radiation;Radiation Dose Unit;radiological imaging;radiologist;Radiology Information Systems;Radiology Specialty;Randomized, Controlled Trials;Recommendation;Report (document);Reporting;Resources;Risk;San Francisco;Secure;service organization;Services;Site;software development;Source;Specific qualifier value;Standardization;structured data;success;Surveys;System;Techniques;Technology;Testing;Time;U-Series Cooperative Agreements;United States Centers for Medicare and Medicaid Services;Universities;Visualization;Work;X-Ray Computed Tomography

PROJECT_TITLE: The Alara Imaging Gateway: Linking Electronic Health Records and Radiology Imaging Exams to Report on National Quality Measures to Reduce Cancer Risk from Computed Tomography (Alara Imaging Gateway)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-J(10)B]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Nutrition;Obesity;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: HONOLULU

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: NARRATIVE / PUBLIC HEALTH RELEVANCE STATEMENT The proposed studies are highly significant because they seek to understand breast cancer risk and survival differences in Asian American, Native Hawaiian and Pacific Islander (AANHPI) ethnic minority women. We will calibrate established radiomic risk features in mammogram images for AANHPI, assess markers of tissue microenvironment in breast tumors, and use already collected measures of fatness, including fat around the internal organs of the abdomen (visceral fat) and determine how they influence breast cancer risk and prognosis in AANHPI women. Thus, this advance is expected to have a high impact on health and well-being by improving risk and prognosis prediction and better identifying high risk women for further assessment or tailored therapy.

PI_NAMEs: SHEPHERD, JOHN ALAN (contact)

PROJECT_TERMS: 3-Dimensional;Abdomen;Adipose tissue;American;anti-cancer research;Architecture;Artificial Intelligence;Asian Americans;Biological Assay;Biological Markers;Blood;Body fat;Body mass index;Breast;Breast Cancer gene;Breast Cancer Model;Breast Cancer Patient;Breast Cancer Risk Factor;breast cancer survival;breast density;breast imaging;Calibration;cancer health disparity;Cancer Prognosis;cancer survival;CD36 gene;Cd68;CD8B1 gene;Cessation of life;Characteristics;Chinese;Clinical Markers;clinically relevant;cohort;Cohort Studies;comparative;deep learning;Disease;Disparity;Early Diagnosis;Early treatment;ERBB2 gene;Estrogen Receptors;Estrogens;ethnic difference;Ethnic Minority Women;Ethnic Origin;Ethnic Population;Evaluation;experience;Fatty acid glycerol esters;Gene Expression Profile;genetic risk factor;Goals;Hawaii;Health;High Risk Woman;hormone receptor-positive;Image;imaging biomarker;improved;Incidence;individualized medicine;Japan;Japanese;Japanese American;Joints;Link;Machine Learning;Malignant Breast Neoplasm;Mammary Neoplasms;Mammographic Density;Mammographic screening;Mammography;mammography registry;Measures;Mediating;migration;Minority;minority health;minority health disparity;modifiable risk;Molecular;molecular modeling;molecular subtypes;mortality;multi-ethnic;nano-string;Native Hawaiian;Native Hawaiian or Other Pacific Islander;Obesity;Organ;Outcome;Pacific Islands;Participant;Pathology;Pattern;Personal Satisfaction;Phenotype;Population;Population Sciences;Postmenopause;Prevention;Primary Prevention;Progesterone Receptors;Prognosis;prognostic;prognostic model;prognostic significance;protein biomarkers;public health relevance;Race;racial difference;racial diversity;racial population;radiomics;Reporting;reproductive;Research;Residual state;Resources;Risk;Risk Factors;risk prediction model;screening;Source;subcutaneous;Subgroup;Survival Analysis;Therapeutic;Tissue Banks;tissue biomarkers;Tissues;Translating;tumor;Tumor Markers;tumor registry;virtual;Visceral;Visceral fat;Visit;White Women;Woman;women's morbidity;Women's mortality;ZNF217 gene

PROJECT_TITLE: Project 3: Inter-Relationships and Prognostic Significance of Breast Cancer Radiomic Risk Features, Tissue Microenvironment, and Adiposity


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Breast Cancer;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Services;Prevention;Primary Health Care;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PI_NAMEs: CHUNG, MICHAEL HOONBAE (contact)

PROJECT_TERMS: Acceleration;Adoption;Advocate;Africa South of the Sahara;Awareness;base;Breast;Breast Cancer Detection;Breast Cancer Early Detection;Breast Cancer Treatment;breast exam;Cancer Control;Cancer Etiology;candidate identification;candidate selection;career;Caring;Cervical Cancer Screening;Clinical;clinical research site;Communities;community engagement;Complex;Consolidated Framework for Implementation Research;cost;County;Data;design;Development;Diagnosis;Early Diagnosis;Early treatment;Effectiveness;Eligibility Determination;Equity;evidence base;Evidence based intervention;Faculty;feasibility testing;Focus Groups;Future;Government;Health Personnel;Health Resources;Health system;Healthcare Systems;HIV Seropositivity;Hospitals;implementation evaluation;implementation intervention;implementation outcomes;implementation research;implementation science;implementation/effectiveness;improved;Individual;informant;Information Technology;Inservice Training;Institution;International;International Agency for Research on Cancer;Intervention;intervention mapping;Interview;Kenya;knowledge translation;Link;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Mammography;Maps;Mentors;Methods;mHealth;mobile computing;Modeling;Morbidity - disease rate;mortality;Motivation;multiphase optimization strategy;Nature;Oncology;Outcome;patient navigation;patient oriented;Patients;peer;Phase;pilot test;pilot trial;Policies;population based;Primary Care;primary care provider;Primary Health Care;Process;Proctor framework;programs;Randomized;recruit;Research;Research Personnel;Research Project Grants;Research Support;Resources;scale up;screening;Screening for cancer;screening program;Services;Students;synergism;System;systematic review;Technology;Testing;Training;Universities;uptake;user-friendly;Washington;Woman;Women's mortality

PROJECT_TITLE: Enhanced Cervical Cancer Screening Adoption and Treatment Linkage for HIV positive Women in Kenya (eCASCADE-Kenya)


NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Liver Disease;Lung;Lung Cancer;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: WILKENS, LYNNE R (contact)

PROJECT_TERMS: American;Archives;Asian Americans;Attitude;Bayesian Method;Behavioral;Bioinformatics;Biologic Characteristic;Biological Markers;Biometry;Breast Cancer Prevention;Breast Cancer Risk Assessment Tool;Breast Cancer Risk Factor;Calibration;cancer health disparity;cancer risk;career;cohort;Collection;Communities;Computer software;computerized data processing;Data;Data Analyses;Data Collection;data integration;data management;data quality;data resource;Data Security;data sharing;database of Genotypes and Phenotypes;Deposition;design;Development;dietary adherence;Dietary Intervention;dietary restriction;disparity reduction;DNA Methylation;DNA Sequence Alteration;efficacy testing;Ensure;Equipment and supply inventories;Ethnic Population;experience;Fatty acid glycerol esters;Fibrosis;Funding;Gene Expression;genome-wide;Goals;Guidelines;Hawaii;health equity;high risk;improved;Individual;Information Systems;Informed Consent;Intention;Liver;liver stiffness;lung cancer screening;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Mammography;mammography registry;Manuscripts;methylation biomarker;minority health;minority health disparity;Minority Health Research;Modeling;Molecular;multi-ethnic;Native Hawaiian;Native Hawaiian or Other Pacific Islander;non-alcoholic fatty liver disease;novel;Obesity;Outcome;Pacific Islands;Patients;Performance;Population;Population Heterogeneity;Preparation;Prevalence;Prevention;Primary carcinoma of the liver cells;Process;Prognosis;programs;radiomics;Randomized;randomized, clinical trials;recruit;repository;Research;Research Design;Research Personnel;Research Project Grants;Retrieval;Risk;risk prediction model;Sampling;Schedule;screening;Security;sharing platform;Structure;Techniques;Tissue Banks;Tissues;tool;Translational Research;tumor;tumor registry;Tumor Subtype;Tumor Tissue;Woman

PROJECT_TITLE: Core 1: Biostatistics & Bioinformatics Core


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: Chicago

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Very little is known regarding the cell morphology and synaptic connectivity within the newly discovered rostromedial tegmental nucleus (RMTg) – a region implicated in the neural mechanisms underlying alcohol use disorder. Recent work from our laboratory reveals a dense projection from the mPFC to the RMTg but little is known about how functionally distinct subregions of the mPFC regulate RMTg signaling. The proposed project will combine circuit-specific labeling with state-of-the-art connectomics approaches to determine the effect of chronic ethanol exposure on cell morphology within the RMTg and the synaptic organization of cortical input to the region.

PI_NAMEs: BOERGENS, KEVIN MICHAEL;GLOVER, ELIZABETH J (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: 3-Dimensional;addiction;Address;Affect;alcohol effect;alcohol exposure;alcohol seeking behavior;alcohol use disorder;Applications Grants;Automobile Driving;Aversive Stimulus;Behavior;Behavioral;Brain region;Cell Nucleus;cell type;Cellular Morphology;Cellular Structures;Characteristics;Chronic;comparison group;Complex;connectome;cost;Data;Data Set;density;Dependence;design;Development;dopaminergic neuron;Drug Exposure;Electron Microscope;Ethanol;Exhibits;experimental study;Extinction;Foundations;Future;Genetic Transcription;Heterogeneity;insight;interest;Interneurons;Investigation;Label;Laboratories;Maps;Medial;Mediating;Midbrain structure;Morphology;motivated behavior;nanometer resolution;neurobiological mechanism;Neurobiology;neurochemistry;neuromechanism;Neurons;Neurosciences Research;novel;Nucleus Accumbens;Pattern;Phenotype;Physiology;Play;Prefrontal Cortex;Prevalence;Psychological reinforcement;Rattus;Regulation;Research;response;Rewards;Role;Signal Transduction;Subcellular Anatomy;Synapses;synaptic function;Synaptic plasticity;Techniques;Ventral Tegmental Area;Work

PROJECT_TITLE: Effect of chronic ethanol exposure on synaptic organization in the rostromedial tegmental nucleus

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: Branford

ORG_NAME: ABBRATECH, INC.

PHR: NARRATIVE While there are already some established methods for antibody validation, there are still issues with the specificity, cross-reactivity, reproducibility, sensitivity, and accuracy of them. This is especially true for antibodies directed against post-translationally modified proteins. The proposed Phase II effort aims to address these issues by investigating the effects of post-translational modifications, comparing our MILKSHAKE method with other established methods for quantifying specificity and sensitivity, using our Sundae method for evaluating the importance of paratope specificity, and our Epivolve method for the discovery and validation of glycosylation-specific antibodies. The proposal also includes a means for the dissemination and commercialization of this Phase II project, which will increase the impact of this effort. Overall, the proposed research has the potential to contribute to the development of more reliable and accurate antibody validation methods and improve the reproducibility of biomedical research.

PI_NAMEs: WEINER, MICHAEL P (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Acetylation;Address;Affect;Affinity;Antibodies;Antibody Binding Sites;Antibody Specificity;Area;Benchmarking;Binding;Biological Assay;Biomedical Research;Biotechnology;Catalogs;central database;Collaborations;commercialization;Communities;cross reactivity;Custom;Data;Detection;Development;Disease;Educational workshop;Ensure;Epitopes;Flow Cytometry;Future;Genetic Polymorphism;glycosylation;Goals;improved;industry partner;innovation;insight;ipilimumab;Knowledge;Malignant Neoplasms;Mammalian Cell;Manuals;Marketing;Measures;Methods;Methylation;Modeling;Molecular Biology;Names;Pharmacologic Substance;Phase;Phosphorylation;Phosphorylation Site;Post-Translational Protein Processing;Protein Glycosylation;Proteins;Proteome;Proteomics;Protocols documentation;Publishing;Reagent;Reproducibility;Research;Research Personnel;Sensitivity and Specificity;Services;shared database;sharing platform;Site;Small Business Innovation Research Grant;Specificity;success;symposium;Techniques;Technology;technology validation;Therapeutic antibodies;tool;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Method for the validation by Western analysis of affinity reagents against post-translationally modified proteins.


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: NEW YORK

ORG_DEPT: CHEMISTRY

ORG_NAME: HUNTER COLLEGE

ORG_STATE: NY

PHR: Project Narrative  Lyme disease is a tick-borne disease caused by bacterial spirochetes, the most prevalent vector-borne disease in the United States, and an ever-worsening public health problem. In this proposal, we will develop novel PET radiopharmaceuticals that target the bacteria responsible for Lyme disease — Borrelia burgdoferi sensu lato (Bbsl) ¾ and thus facilitate the non-invasive imaging of Bbsl infection. These probes could have a paradigm-shifting impact on both the basic science and clinical management of Lyme disease, with applications ranging from preclinical research to clinical imaging.

PI_NAMEs: GOMES-SOLECKI, MARIA ;QIU, WEIGANG ;ZEGLIS, BRIAN MATTHEW (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Active Sites;Affect;Affinity;Aftercare;Antibiotic Therapy;Area;Autoradiography;Bacteria;Basic Science;Binding;Biological;Biological Markers;Biological Testing;Black-legged Tick;Borrelia;Borrelia burgdorferi;Borrelia burgdorferi Group;Centers for Disease Control and Prevention (U.S.);Chemicals;Clinic;Clinical;clinical development;clinical imaging;Clinical Management;Clinical Research;Data;Dedications;Development;Diagnosis;Diagnostic;Disease;disease model;Doxycycline;Drug Kinetics;efficacy evaluation;Evaluation;fighting;Functional disorder;Health Care Costs;Histology;Image;imaging agent;imaging probe;Immunoconjugates;Immunohistochemistry;ImmunoPET;In Vitro;in vivo;Infection;Investigation;Label;Laboratories;longitudinal positron emission tomography;Lyme Disease;Lyme disease diagnosis;maltreatment;member;Midwestern United States;Modeling;molecular imaging;Monitor;Monoclonal Antibodies;Morbidity - disease rate;mouse model;Mus;nanobodies;new technology;non-invasive imaging;novel;novel therapeutics;novel vaccines;Order Spirochaetales;patient response;Performance;Persons;Positron-Emission Tomography;Post Treatment Lyme Disease Syndrome;pre-clinical research;Proteins;Public Health;Radioimmunoconjugate;Radiopharmaceuticals;radiotracer;Reporting;Research;response;Risk;Sensitivity and Specificity;Site;Specificity;subcutaneous;Sulfhydryl Compounds;Surface;Surface Antigens;targeted agent;targeted imaging;Techniques;Therapeutic;tick-borne;Tick-Borne Diseases;Ticks;Time;tool;tool development;trait;transmission process;treatment response;United States;Vaccination;Vaccine Clinical Trial;Validation;Variant;Vector-transmitted infectious disease;Visualization;Work

PROJECT_TITLE: ImmunoPET Probes for the Imaging of Lyme Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-C(03)M]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: CASSEL, KEVIN DARRYL (contact)

PROJECT_TERMS: Address;Advocate;American;Asian Americans;Awareness;Biological Markers;Breast Cancer Risk Factor;California;Cancer Center;cancer health disparity;cancer risk;career;Catchment Area;Clinical Cancer Center;Clinical Trials;cohort;Collaborations;Communities;community advisory board;community collaboration;community engagement;community organizations;Community Outreach;comorbidity;Complex;complex data;Data;Data Collection;Development;Diagnosis;dietary;disease disparity;Education;Eligibility Determination;ethnic difference;ethnic disparity;Ethnic Origin;Ethnic Population;Evaluation;exercise intervention;experience;Focus Groups;Foundations;Funding;Future;Geography;Goals;Hawaii;Health;health care service organization;Health Personnel;high risk;informant;Infrastructure;Institution;Interview;Knowledge;lifestyle intervention;Los Angeles;lung cancer screening;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant Neoplasms;Mammography;Minority Groups;minority health disparity;Minority Health Research;multi-ethnic;Native Hawaiian;Native Hawaiian or Other Pacific Islander;NCI-Designated Cancer Center;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;Obesity;Observational Study;Oncology;Outcome;outreach;Overweight;Pacific Islands;Participant;Patients;Perception;Phenotype;Physicians;pilot test;Play;Primary Care;Process;programs;Protocols documentation;Provider;Race;racial difference;racial population;radiomics;Randomized;recruit;Recruitment Activity;Reproduction spores;Research;Research Personnel;Research Project Grants;Risk Assessment;Role;Smoker;smoking cessation;success;Testing;translational impact;Translational Research;Universities;Work

PROJECT_TITLE: Core 2: Outreach & Recruitment Core


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Chronic Pain;Genetics;HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: BIDDEFORD

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF NEW ENGLAND

ORG_STATE: ME

PHR: Narrative “Improve HIV-related health outcomes of people with HIV” is one of the 4 goals identified in the recently published US National HIV/AIDS Strategy (2022-2025), which involves addressing HIV-associated comorbidities. HIV-associated sensory neuropathy (HIV-SN) is one of the most common neurological complications associated with HIV infection, often painful, and clinically hard to manage. Studies investigating the underlying mechanisms of HIV-SN, and help identify affordable treatment strategies are critical for achieving the national vison for HIV/AIDS “… every person with HIV has high-quality care and treatment,…and can achieve their full potential for health and well-being across the lifespan”.

PI_NAMEs: CAO, LING  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Affect;Animal Model;Animals;Anti-Retroviral Agents;Autopsy;Behavior;Behavioral;Bioinformatics;bioinformatics tool;Cells;Chronic Disease;Clinical;Clinical assessments;comorbidity;cytokine;Data;Detection;Development;Diagnosis;Doxycycline;drug candidate;Drug Combinations;drug discovery;Effectiveness;FDA approved;Genes;genetic regulatory protein;Genetic Transcription;Genetically Modified Animals;Goals;Health;Highly Active Antiretroviral Therapy;HIV;HIV Infections;HIV-1;Human;Immunohistochemistry;improved;in vivo;Individual;Infection;Inflammation;Investigation;IRAK1 gene;Knock-out;Knowledge;life span;Location;Lumbar spinal cord structure;Mediating;Modeling;Mus;nano-string;Neural Conduction;Neurologic;Neuropathy;Outcome;overexpression;Pain;Pain management;painful neuropathy;Pathway interactions;Patients;Peripheral Nervous System Diseases;Personal Satisfaction;Persons;Pharmaceutical Preparations;Pharmacotherapy;Physiological;Pre-Clinical Model;Prevalence;Process;Property;Proteins;Publishing;Quality of Care;Quantitative Reverse Transcriptase PCR;receptor binding;recruit;Regulation;Reporting;Resources;RNA;Role;sensory neuropathy;Signal Pathway;Signaling Molecule;sound;Testing;Time;Toll-Like Receptor Pathway;Toll-like receptors;Trans-Activators;Transcription Coactivator;Transgenic Mice;treatment strategy;Variant

PROJECT_TITLE: HIV Tat-associated Sensory Neuropathy and the Contribution of Toll-like Receptor Pathway

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Liver Cancer;Liver Disease;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Women's Health Research

PI_NAMEs: HERNANDEZ, BRENDA YUKARI (contact)

PROJECT_TERMS: Address;Affect;anti-cancer research;Asian Americans;Asian population;biobank;Biological Specimen Banks;Blood;Blood specimen;Breast;Cancer Burden;Cancer Center;cancer health disparity;Cancer Patient;Cancer Research Project;cancer risk;career;Cells;Choline Kinase;Clinical;Cohort Studies;Collection;Colorectal;Colorectal Cancer;Communities;Community Hospitals;Community Participation;Consent;Cultural Sensitivity;Development;Diagnosis;diagnosis standard;Disparate;Endometrial Carcinoma;Endometrium;Ensure;epidemiology study;Equity;ethnic difference;ethnic disparity;ethnic diversity;ethnic minority;ethnic minority population;Ethnic Population;Etiology;Excess Mortality;experience;Feces;Filipino;Formalin;Foundations;Freezing;Future;Goals;Hawaii;Hexokinase 2;Human;human subject;Image;Individual;Infrastructure;Investigation;Japanese;Japanese American;Length;Liver;Lung;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;malignant stomach neoplasm;Mammary Gland Parenchyma;MDM2 gene;Medical;Melanoma;Methylation;minimally invasive;minority communities;Minority Groups;minority health disparity;Minority Health Research;mortality;multi-ethnic;Multiple Myeloma;Native Hawaiian;Native Hawaiian or Other Pacific Islander;nonalcoholic steatohepatitis;Not Hispanic or Latino;Oral;Oral cavity;Organoids;Oropharyngeal;Outcome;Pacific Islander;Paraffin Embedding;Pathogenesis;Pathology;Pathway interactions;Population;Primary carcinoma of the liver cells;Procedures;Program Research Project Grants;programs;prospective;Protein Kinase;racial difference;racial disparity;racial minority;racial minority population;Reliability of Results;Reporting;repository;Research;Research Personnel;Resources;Samoan;sample collection;Sampling;Slide;Somatomedins;Specimen;SPHK1 enzyme;Standardization;Stomach;telomere;Testing;Tissues;TP53 gene;translational cancer research;translational potential;Translational Research;tumor;tumor registry;Tumor Tissue;Universities;Urine;Viral hepatitis

PROJECT_TITLE: Core 3: Pathology & Biospecimens Core


ADMINISTERING_IC: HD

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Infectious Diseases;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SEATTLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Nearly 10% of infants are born prematurely, with outcomes including behavioral and cognitive problems, severe disability, and death. There are currently no targeted neuroprotective interventions for preterm infants, and mounting evidence suggests that multiple therapies will need to be applied in order to see robust global neuroprotection. In this proposal we describe complementary in vitro and in vivo techniques in the early preterm ferret to determine combinatorial therapies with the greatest likelihood of benefit – we provide a preclinical platform that can create a pipeline for translation to clinical neuroprotection trials in premature infants.

PI_NAMEs: NANCE, ELIZABETH A (contact);WOOD, THOMAS

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: Acetoacetates;Adolescence;Animals;Anti-Inflammatory Agents;Antibiotics;Antioxidants;Apoptotic;ARHGEF5 gene;Attention deficit hyperactivity disorder;autism spectrum disorder;Automobile Driving;Azithromycin;Bacterial Infections;Behavior;Behavior assessment;Behavioral;Brain;Brain Hypoxia-Ischemia;Brain Injuries;Brain Pathology;Brain region;Caffeine;Cells;Cerebral Palsy;Cessation of life;Clinical;Clinical Trials;Cognition;Cognitive;combinatorial;connectome;Country;Data;deprivation;Development;Developmental Delay Disorders;Diffusion Magnetic Resonance Imaging;disability;Dose;Drug Interactions;Drug Kinetics;Ensure;Erythropoietin;exenatide;experience;Exposure to;extreme prematurity;Ferrets;Genes;Gestational Age;Glucose;Glutamate Receptor;hearing impairment;Human;Hyperoxia;Hypoxia;Immunohistochemistry;Impaired cognition;improved;In Vitro;in vivo;in vivo evaluation;Income;Infant;Inflammation;Inflammatory;Injury;Intervention;intraamniotic infection;Length of Stay;Long-Term Effects;Magnetic Resonance Imaging;Melatonin;Modeling;Morbidity - disease rate;Morphology;mortality;Motor;nerve stem cell;Neurodevelopmental Impairment;Neurons;neuropathology;neuroprotection;Neuroprotective Agents;oligodendrocyte lineage;Outcome;oxidative damage;Oxidative Stress;Oxygen;Pathology;Pathway interactions;Pattern;Periodontitis;Pharmaceutical Preparations;Population;postnatal;pre-clinical;Predisposition;Pregnancy;Premature Birth;Premature Infant;Preterm brain injury;preterm newborn;Publications;Reflex action;regional difference;Research;response to injury;Risk;Slice;Specificity;stem cell exosomes;Structure;Survivors;Techniques;Testing;Therapeutic;therapy development;transcriptome;transcriptomics;Translating;translational pipeline;treatment effect;treatment response;United States;Visual impairment;Vitamin E;white matter;white matter injury

PROJECT_TITLE: Combinatorial Neuroprotective Strategies for Preterm Brain Injury

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: MASKARINEC, GERTRAUD  (contact)

PROJECT_TERMS: Address;Area;Award;Behavioral;Biological;Cancer Burden;Cancer Center;cancer health disparity;cancer risk;Catchment Area;Characteristics;clinical diagnostics;Clinical Trials;Collaborations;Community Outreach;Creativeness;Data;Development;Education;Educational workshop;Elements;Ensure;Equity;ethnic difference;Ethnic Origin;Ethnic Population;Evaluation;Faculty;Fostering;Funding;Future;Goals;Hawaii;Human;improved;innovation;Institution;inter-institutional;Intervention;Investigation;Leadership;Malignant Neoplasms;Mentors;minority disparity;minority health;minority health disparity;Minority Health Research;Mission;Monitor;National Cancer Institute;Outcome;Patient Care;Pilot Projects;Population Heterogeneity;Process;programs;racial difference;racial population;Request for Applications;Research;Research Infrastructure;Research Personnel;Research Project Grants;Review Committee;Seminal;Standardization;Strategic Planning;success;Talents;Therapeutic;Translating;translational impact;Translational Research;Underrepresented Minority;Universities;Work

PROJECT_TITLE: Developmental Research Program


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Heart Disease;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Stroke

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Clinical evidence suggests survivors of cardiac arrest experience emotional disorders in addition to well-defined cognitive dysfunction. I have identified a sex and circuit specific amygdala dysfunction in a translational mouse model of cardiac arrest. To further understand the mechanism of this dysfunction and provide molecular targets for translatable therapies, I have proposed the hypothesis that GCI induces dysfunction of LTCC's within the BLA of male mice, thereby contributing to the deficits in amygdala-dependent behavior and LTP.

PI_NAMEs: VIGIL, JOSE JACOB (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Affective;Amygdaloid structure;Animal Model;Animals;Anxiety;Association Learning;Award;Behavior;Behavioral;behavioral response;Biological Models;Brain;Calcium;Cardiopulmonary Resuscitation;career;Cerebral Ischemia;Clinical;Cognitive;Communication;Complement;conditioned fear;Cues;Dendritic Spines;Development;Distal;Education;Electrophysiology (science);Emotional;Emotional disorder;emotional experience;emotional functioning;Excitatory Postsynaptic Potentials;experience;experimental study;Food;Functional disorder;Future;Goals;Heart Arrest;hippocampal pyramidal neuron;Hippocampus;Human;Image;Impaired cognition;Impairment;improved;in vivo;in vivo calcium imaging;Individual;L-Type Calcium Channels;Learning;Long-Term Potentiation;male;Measurement;Measures;Mediating;Memory;Mental Depression;Methods;Modeling;Molecular;Molecular Target;mouse model;Mus;N-Methyl-D-Aspartate Receptors;Nerve Degeneration;neuropsychiatric disorder;Neurosciences;Outcome;patient population;Pharmacology;Phase;Population;Post-Traumatic Stress Disorders;Postdoctoral Fellow;pre-doctoral;Prevalence;Quality of life;Research;Research Personnel;response;Resuscitation;saliva secretion;Science;sensory stimulus;sex;sexual dimorphism;Site;Slice;Stimulus;Survivors;Synaptic Transmission;System;Techniques;Training;two-photon;Universities;young adult

PROJECT_TITLE: Sexually Dimorphic Amygdala Dysfunction in a Mouse Model of Global Cerebral Ischemia

STUDY_SECTION: NST

STUDY_SECTION_NAME: Neurological Sciences Training 3 Study Section[NST-3]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Achievement;Affinity;Area;Asian Americans;Award;Cancer Center;cancer health disparity;cancer prevention;cancer risk;cancer therapy;candidate selection;career;career development;Clinical Trials;Collaborations;Communities;design;Development;Disabled Persons;Discipline;Disparity;effectiveness evaluation;Ensure;ethnic disparity;Ethnic Origin;Ethnic Population;Faculty;faculty mentor;Focus Groups;Fostering;Funding;Goals;Grant;Hawaii;health care quality;improved;Incidence;Individual;innovation;Institution;Intervention;Journals;Leadership;Malignant Neoplasms;member;Mentors;Mentorship;Minority;minority disparity;minority health;minority health disparity;Minority Health Research;Monitor;multi-ethnic;multidisciplinary;Native Hawaiian or Other Pacific Islander;Outcome;Outcome Measure;Pacific Islands;Policies;Population;Procedures;Process;Program Effectiveness;programs;Progress Reports;Publications;Race;racial disparity;racial population;Research;Research Personnel;Research Support;Resources;Scientist;senior faculty;Services;Sexual and Gender Minorities;Standardization;success;System;Talents;Training;Translational Research;Underrepresented Populations;Universities;Veterans;Woman;Work;Writing

PROJECT_TITLE: Career Enhancement Program


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cancer;Cancer Genomics;Cardiovascular;Childhood Leukemia;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Down Syndrome;Genetics;Heart Disease;Hematology;Human Genome;Intellectual and Developmental Disabilities (IDD);Neuroblastoma;Neurosciences;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: NARRATIVE In our prior work, we have identified multiple novel congenital anomaly-cancer associations by linking data from population-based birth-defects and cancer registries from four states. Here, we propose to expand this study to seven additional states to analyze a cohort representing >25 million live births and approximately 35% of the US population. We will also search for genetic mechanisms driving these associations through the analysis of whole-genome sequencing data in 20,000 children with congenital anomalies or pediatric cancer, including 2000 sequenced tumors.

PI_NAMEs: HUFF, CHAD DANIEL (contact);LUPO, PHILIP

PROGRAM_OFFICER_NAME: DAEE, DANIELLE L

PROJECT_TERMS: 20 year old;Acute leukemia;Address;Adolescent;Adult;Age Years;All of Us Research Program;Alleles;Alternative Splicing;Automobile Driving;Birth;cancer epidemiology;cancer genomics;cancer predisposition;cancer risk;carcinogenesis;case control;Cause of Death;Child;Child Care;Choanal Atresia;Chromosome abnormality;Chronic;Clinical;cohort;Congenital Abnormality;congenital anomaly;congenital heart abnormality;Congenital Heart Defects;Data;data registry;Data Set;de novo mutation;Defect;Development;Diagnosis;Disease;Down's Syndrome;epidemiologic data;Epidemiology;Evaluation;Gene Expression;Gene Fusion;General Population;Genes;Genetic;genetic architecture;genetic association;Genetic Counseling;Genetic Variation;Genome;genome sequencing;genome wide association study;Genomic approach;genomic data;Genomics;Genotype;Germ Lines;Germ-Line Mutation;Health;improved;Individual;insight;Joints;Knowledge;large datasets;Lead;leukemia;Link;Live Birth;Malignant Childhood Neoplasm;Malignant Neoplasms;Modeling;Mutation;neoplasm registry;Neuroblastoma;novel;Nucleic Acid Regulatory Sequences;Outcome;Pathogenicity;Patients;Pattern;Pediatric Research;Phenotype;Population;population based;Populations at Risk;Predisposition;proband;programs;Quality Control;rare variant;Registries;Reporting;response;Risk;Risk Factors;secondary analysis;Survivors;Susceptibility Gene;Syndrome;Testing;therapeutic target;transcriptome sequencing;trend;tumor;United States;Variant;whole genome;Work

PROJECT_TITLE: Integrating Epidemiologic and Genomic Data to Elucidate the Genetic Overlap Between Congenital Anomalies and Pediatric Cancer

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: BETHLEHEM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: LEHIGH UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative Neuropsychiatric symptoms (NPS) affect up to 97% of patients during the course of AD and may accelerate cognitive declines and institutionalization. In this project, we will assess neural circuits and subtypes underlying dimensions of NPS by leveraging sophisticated machine learning tools. Successful outcomes of the project will lead to an improved understanding of the neurobiological mechanism underlying NPS and its clinical relevance, form a promising new avenue to potentially guide the intervention of NPS and better the management of AD progression, and hence pave the way towards precision medicine of AD dementia.

PI_NAMEs: ZHANG, YU  (contact)

PROGRAM_OFFICER_NAME: PETANCESKA, SUZANA

PROJECT_TERMS: Acceleration;Affect;Aggressive behavior;Agitation;Alleles;Alzheimer's Disease;Amyloid beta-Protein;analytical tool;Anxiety;apolipoprotein E-4;associated symptom;Behavior;Brain;Characteristics;clinical diagnosis;clinical predictors;clinically relevant;Cluster Analysis;cognitive function;cohort;common symptom;Communities;Computer software;connectome;Data;Dementia;Diagnosis;Dimensions;Disease Progression;Dropout;Early Diagnosis;Etiology;Functional disorder;Functional Magnetic Resonance Imaging;Guidelines;Impaired cognition;improved;Individual;Institutionalization;Intervention;Link;Machine Learning;Maps;Measures;Mental Depression;mild cognitive impairment;Modeling;Nerve Degeneration;neural circuit;neural patterning;neurobiological mechanism;Neurobiology;neuroimaging;neurophysiology;neuropsychiatric symptom;neuropsychiatry;Neuropsychology;novel;Outcome;Patients;Pattern;Phenotype;pre-clinical;precision medicine;prevent;Psychopathology;Psychoses;Publishing;Reproducibility;Research;response;Rest;Severities;Sleep disturbances;Staging;Symptoms;Testing;Time;tool;Validation

PROJECT_TITLE: Assess Neural Circuits and Subtypes Underlying Dimensions of Neuropsychiatric Symptoms in Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-C(02)M]


ADMINISTERING_IC: DC

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Brain Disorders;Cerebral Palsy;Clinical Research;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rehabilitation

ORG_CITY: MADISON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative This research will validate measures that can be used in the clinic to assess different features of speech that may be affected in children with cerebral palsy. Results will help speech therapists determine if specific aspects of a child’s speech (e.g. voice quality, nasality, breath support, intonation) are disordered or fall within age-expected ranges. Results will also help us understand what problems are responsible for reduced speech intelligibility and will point to directions for speech therapy.

PI_NAMEs: HUSTAD, KATHERINE C (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Address;Advanced Development;Affect;Age;age related;age stratification;Auditory;Cerebral Palsy;Characteristics;Child;Childhood;Clinic;Clinical;clinical application;clinical practice;clinically relevant;combinatorial;Communication;Data;Development;Developmental Course;Diagnosis;Diagnostic Procedure;Diagnostic tests;Differential Diagnosis;Disease;Dysarthria;Early identification;Early treatment;Education;evidence base;falls;Foundations;Funding;German population;Goals;Growth;Impairment;improved;Individual;Intervention;Knowledge;Laboratories;Language;Measures;Methods;Modeling;motor disorder;Nose;novel;Outcome;Pathologist;Pattern;Performance;Population;Positioning Attribute;Production;Quality of life;Research;Sampling;sex;social engagement;Speech;Speech Development;speech disorder diagnosis;Speech Disorders;Speech Intelligibility;Speech Therapist;Speech Therapy;Time;tool;Validation;Voice Quality;Work

PROJECT_TITLE: Differential Diagnosis of Functional Speech Deficits in Children with Cerebral Palsy

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Sleep Research;Social Determinants of Health

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: This K01 International Research Scientist Development Award seeks to provide the applicant experience in primary data collection in Bangladesh, knowledge, and skills in the measurement of sleep health and executive function, advanced statistical methods to examine socio-ecologic determinants of sleep, and community-based participatory research approaches for intervention adaptation to support the applicant's transition to research independence. Through the training embedded in this award, the applicant will develop the skills and expertise necessary to study sleep health of preschool children as a modifiable behavior to improve executive function and reduce the risk of childhood obesity. A feasible and culturally appropriate sleep health promotion intervention adapted during this training has the potential to improve long-term physical and developmental outcomes for millions of children in low- and middle-income countries.

PI_NAMEs: SANIA, AYESHA  (contact)

PROGRAM_OFFICER_NAME: HAYES, UNJA

PROJECT_TERMS: 4 year old;Academic Medical Centers;Achievement;Age;alertness;Asia;Asian;Award;Bangladesh;Bangladeshi;Behavior;Behavior Therapy;Child;Child Health;Child Rearing;Childhood;Cluster randomized trial;community advisory board;community based participatory research;Complex;Country;Crowding;Data;Data Collection;design;Development;Diabetes Mellitus;Dimensions;early childhood;Economic Conditions;Economics;Epidemiologist;Epidemiology;Evaluation;executive function;experience;Fogarty International Center;global health;Goals;Growth;Health;Health Promotion;Health Sciences;Hour;Household;implementation science;improved;Income;Individual;Interdisciplinary Study;International;Intervention;Knowledge;Knowledge acquisition;late life;Learning;Life;Link;low and middle-income countries;lower income families;Measures;Medicine;Mentored Research Scientist Development Award;Mentors;Methods;modifiable behavior;modifiable risk;Modification;Moods;Mother-Child Relations;neurodevelopment;novel;Obesity;obesity in children;obesity risk;Outcome;Parent-Child Relations;Performance;Phase;Physical activity;physical conditioning;Physicians;Polysomnography;poor sleep;Preschool Child;programs;Psychiatry;Psychology;Public Health;public health priorities;Recommendation;Research;Research Personnel;Risk Factors;Risk Reduction;Role;satisfaction;skills;Sleep;sleep behavior;sleep health;social;social health determinants;social skills;socioeconomics;Statistical Methods;Stress;therapy development;Training;trial design;tv watching;wearable device;Work;World Health Organization

PROJECT_TITLE: Sleep health of preschool children in Bangladesh: predictors, role on executive function and obesity, and sleep promotion intervention

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-P(55)R]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Metastasis, the spread of cancer throughout the body, is one of the primary causes of cancer death, yet there are no therapeutic strategies to inhibit metastatic invasion. Cancer cells are known to undergo metabolic reprogramming to promote tumor growth, but the metabolic drivers of metastasis are unknown. This research will define the how lipid storage and catabolism fuel metastatic invasion in pancreatic cancer.

PI_NAMEs: RAZIDLO, GINA LYNN (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Acute;Automobile Driving;Biochemical;Biochemistry;cancer cell;Cancer Etiology;cancer survival;cancer therapy;Catabolism;cell motility;Cell Respiration;Cells;Cellular biology;Cessation of life;Circulation;Data;Dependence;Disease Progression;Down-Regulation;Energy-Generating Resources;Environment;Enzymes;Epigenetic Process;experimental study;fatty acid oxidation;Fatty Acids;Goals;improved;In Vitro;in vivo;in vivo Model;insight;Invaded;KRAS oncogenesis;KRAS2 gene;Lead;Lipase;lipid metabolism;Lipids;Lipolysis;live cell imaging;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Metabolic;Metabolic Pathway;Microtubules;migration;Mitochondria;Molecular;mouse model;Mutate;Mutation;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel;novel therapeutic intervention;Obesity;Oncogenes;Outcome;Oxidative Phosphorylation;pancreatic cancer cells;pancreatic cancer model;Pathway interactions;Patients;Process;programs;Quantitative Microscopy;Regulation;Research;Respiration;Risk Factors;Role;Signal Transduction;Source;spatial integration;sterol esterase;Stimulus;targeted treatment;Testing;Therapeutic;therapeutic target;trafficking;Transcriptional Regulation;Tumor Cell Invasion;Tumor Cell Migration;tumor growth;tumor metabolism;tumor progression;Tumor Promotion;uptake;virtual

PROJECT_TITLE: Lipid storage and catabolism as drivers of metastatic invasion

STUDY_SECTION: TEHM

STUDY_SECTION_NAME: Tumor Evolution, Heterogeneity and Metastasis Study Section[TEHM]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Disease;Microbiome;Substance Misuse

ORG_CITY: LA JOLLA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Alcohol use disorder and alcohol-associated liver disease are associated with changes in the gut microbiome, but the mechanisms by which the gut microbiome increases individuals’ risk for these disorders is not well understood. Our research investigates how ethanol production by gut microbes may increase alcohol use in the host and exacerbate liver disease. These studies will enhance our understanding of how gut microbial metabolites contribute to alcohol use disorder and alcohol-associated liver disease and lead to discovery of improved therapeutic interventions.

PI_NAMEs: HSU, CYNTHIA LI-SHIN (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: absorption;Advisory Committees;Aerobic;Affect;alcohol abuse therapy;Alcohol consumption;Alcohol dependence;alcohol use disorder;Alcohol withdrawal syndrome;Alcoholic Liver Diseases;Alcohols;anti-fungal agents;Antibiotic Therapy;Antibiotics;antimicrobial;Bacteria;Bacterial Translocation;Behavior;behavior test;Behavioral;Biological;Bioreactors;Blood Circulation;Brain;California;career development;Chronic;chronic alcohol ingestion;Cirrhosis;clinical diagnosis;cohort;craving;Data;Development Plans;Disease Progression;Disease remission;disorder risk;Enrollment;Environment;Enzymes;Ethanol;experimental study;fatty liver disease;Feces;Fibrosis;Flare;fungus;Gene Expression;Gene Family;Genes;Germ-Free;Gnotobiotic;gut bacteria;gut microbes;gut microbiome;gut microbiota;Hepatic;Histopathology;Household;humanized mouse;improved;Individual;Inflammatory;interdisciplinary approach;Intestinal permeability;Intoxication;Liver;Liver diseases;liver injury;loss of function;Measures;Mentors;Metabolism;metagenomic sequencing;Metagenomics;Methods;Microbe;microbial;microbiota;Minority;Morbidity - disease rate;mortality;mouse model;Mus;mutant;neuroinflammation;neuropathology;Pathologic;Pathology;patient subsets;Patients;Phase;Physicians;Physiological;Population;Predisposition;Prevalence;Prevention strategy;Production;progression risk;psychological symptom;Publishing;Research;research and development;Resources;review of reported cases;Risk Factors;Role;Scientist;Symptoms;Syndrome;Techniques;Testing;Therapeutic;Therapeutic Intervention;Training;Universities

PROJECT_TITLE: Role of gut microbial ethanol production in alcohol use disorder and alcohol-associated liver disease

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: PROJECT NARRATIVE Cigarette smoking remains the leading preventable cause of morbidity and mortality in the United States. SBP-9330 is a positive allosteric modulator of metabotropic glutamate receptor subtype 2 (mGlu2) that modulates glutamatergic neurotransmission in brain circuits involved in nicotine and other substance use disorders that has shown promise in a Phase 1 clinical study. We propose to continue clinical development of SBP-9330 as a novel therapeutic agent for nicotine addiction.

PI_NAMEs: ANTHENELLI, ROBERT M;COSFORD, NICHOLAS DAVID (contact);VELICELEBI, GONUL

PROGRAM_OFFICER_NAME: SOUSA, JASON CARLOS

PROJECT_TERMS: absorption;Abstinence;Achievement;Acute;ADME Study;Adult;Adverse event;Animal Model;Applications Grants;Autoradiography;Biological Availability;Body System;Brain;Bupropion;Canis familiaris;Categories;Cause of Death;Cessation of life;Chemistry;cigarette smoking;clinical development;Clinical Research;Clinical Trials;cohort;Collaborations;Cues;Cytochrome P450;Data;design;Development;Disease;Dose;Double-Blind Method;Drug Kinetics;Drug or chemical Tissue Distribution;drug reinforcement;Drug usage;environmental tobacco smoke exposure;Evaluation;Excretory function;experience;Funding;Gastrointestinal Diseases;Glutamates;good laboratory practice;Good Manufacturing Process;Grant;Hepatic;Human;in vitro Assay;Investigation;Investigational Drugs;Kidney;Label;manufacture;Measures;Metabolic;metabolic abnormality assessment;Metabolism;Metabotropic Glutamate Receptors;Morbidity - disease rate;mortality;multidisciplinary;Nervous System Disorder;neurotransmission;Nicotine;nicotine cessation;Nicotine Dependence;nicotine replacement;nicotine seeking behavior;nicotine self-administration;nicotine treatment;Nicotinic Agents;non-smoker;novel drug class;novel therapeutics;Oral;Penetration;Pharmaceutical Preparations;Phase;phase 1 study;phase 2 study;Placebo Control;Plasma;positive allosteric modulator;pre-clinical;Prevalence;Productivity;Property;Qualifying;Randomized;Rattus;receptor;relapse prevention;Research;Research Personnel;response;Safety;Series;Serious Adverse Event;Severities;small molecule;Smoker;Smoking;smoking cessation;statistics;Substance Use Disorder;success;Testing;Therapeutic Agents;therapeutically effective;Time;tobacco smokers;tobacco user;Toxic effect;Toxicology;United States;United States Food and Drug Administration;varenicline;Work

PROJECT_TITLE: Safety/Toxicology, ADME and CMC Activities to Support the Assessment of the mGlu2 PAM SBP-9330 in a Phase 2 Clinical Study in Smokers

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Medication Development Research Study Section[NIDA-L]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE Project Narrative: Mobile methadone is a service delivery model that allows vehicles to dispense methadone as an extension of a community opioid treatment program. This project will evaluate the early implementation of the mobile methadone grant program in New York, where the state has invested in creating new units. The aims include interviews with pilot sites and their community partners, surveys with people who are current or potential mobile unit patients, and the use of geospatial methods to identify communities where there is likely to be high need for mobile services.

PI_NAMEs: SALONER, BRENDAN K (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: Acute;addiction;Address;Area;Attitude;Automobile Driving;barrier to care;Buprenorphine;Calibration;care preference;Caring;Characteristics;Client;Clinic;Communities;Community Integration;Community Outreach;community partners;Community Services;Consolidated Framework for Implementation Research;cost;Counseling;Data;Diagnosis;disability;early experience;experience;Financial cost;Funding;Future;Goals;Grant;Harm Reduction;Health;Health care facility;Health Services Accessibility;HIV;Housing;housing instability;Human Papillomavirus;implementation study;improved;Individual;Institutionalization;interest;Interview;Investments;Location;Long-Term Care;Maps;Medicaid;Medical;medication for opioid use disorder;member;Methadone;methadone patient;methadone treatment;Methods;Motor Vehicles;Naltrexone;National Institute of Drug Abuse;New York;novel strategies;opioid treatment program;opioid use disorder;optimal treatments;Outcome;Overdose;Overdose reduction;overdose risk;Patient Preferences;Patients;Persons;Pharmaceutical Preparations;Population;preference;programs;Provider;Public Health;Recording of previous events;Regulation;Research;residence;Resources;Risk Factors;rural area;Secure;Selection for Treatments;Service delivery model;Services;Shapes;simulation;Site;social stigma;Social Work;Statistical Models;Structure;substance use;Surveys;symptom management;Testing;Time;tool;Transportation;Travel;Uncertainty;United States;urban area

PROJECT_TITLE: Implementation of Mobile Medication Units for Patients with Opioid Use Disorder in New York.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(90)S]


NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Narrative: Mechanical stimulation of the auditory and vestibular sensory organelle, the hair bundle, generates an electrical current by regulating the opening of mechanically gated ion channels. The mechanical properties of hair bundles shape receptor currents and are postulated to provide filtering to the input. The goal of this proposal is to characterize how, and which hair bundle mechanical properties are important for tuning receptor currents.

PI_NAMEs: RICCI, ANTHONY J (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Acoustic Stimulation;Actins;Address;Age;Aging;Animals;antagonist;ATP phosphohydrolase;Auditory;biophysical properties;Biophysics;Brain;Buffers;Calcium;cell type;Cells;channel blockers;Characteristics;Cochlea;Coupled;Data;Data Set;Endolymph;experimental study;Foundations;Frequencies;Generations;Genetic Diseases;genetic manipulation;Goals;Hair;Hair Cells;Image;Individual;Inner Hair Cells;insight;Intervention;Investigation;Ion Channel Gating;Kinetics;Labyrinth;Link;Liquid substance;Location;mechanical properties;Mechanical Stimulation;Mechanics;Modeling;Molecular;Monitor;Morphology;Motion;Motor;Mus;Noise;Organ;Organ Model;Organelles;Outer Hair Cells;Phosphatidylinositol 4,5-Diphosphate;Physiological;Positioning Attribute;Predisposition;Prevention therapy;Process;Property;Protocols documentation;Rana;Rattus;receptor;Receptor Cell;Reporting;response;restoration;Role;Rotation;Saccule structure;Sensory;Sensory Hair;Shapes;Signal Pathway;Signal Transduction;Site;Speed;Stereocilium;Stimulus;synergism;Technology;tectorial membrane;Testing;theories;therapy design;tongue papilla;Translating;Turtles;Usher Syndrome;vestibular system;voltage;Work

PROJECT_TITLE: Probing how hair bundle mechanical properties shape the mechanotransducer receptor current

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PHR: PROJECT NARRATIVE Unintended pregnancies are associated with risks to maternal and child health and Latina immigrants face a variety of contraceptive access barriers. This proposal aims to design and test a stakeholder-informed intervention for integrating maternal contraceptive care coordination in pediatric settings serving Latinx families. This award will help me achieve my long-term career goal of leading pediatric primary care interventions that support contraceptive access equity among parents with limited health care access.

PI_NAMEs: CABALLERO, TANIA MARIA (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Academy;acceptability and feasibility;Address;Adoption;American;Award;bilingualism;care coordination;care costs;career;Caring;Child;Child Health;Childhood;Clinic;Clinical Trials;cohort;collaborative environment;Color;Communities;Contraceptive Agents;Contraceptive Usage;Control Groups;Data;Dedications;Demography;design;Developmental Delay Disorders;Effectiveness;effectiveness measure;Eligibility Determination;Emergency Care;Engineering;Equity;experience;Face;Family;Family health status;Family Planning;Focus Groups;Future;Goals;Health;health care availability;health equity;health organization;Healthcare;Human;Hybrids;Immigrant;Immigrant community;Immigrant family;implementation evaluation;implementation facilitators;implementation framework;implementation outcomes;implementation science;implementation/effectiveness;improved;Individual;innovation;Insurance;Intervention;Interview;Justice;Lactation;Latina;Latina Population;Latinx;Leadership;Learning;Legal Status;Limited English Proficiency;Maps;Maternal and Child Health;Maternal Health;Measures;Medical;medical schools;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;Methods;Mothers;multidisciplinary;Needs Assessment;novel;Outcome;Parents;pediatrician;Pediatrics;person centered;Persons;Postpartum Depression;Postpartum Period;Pregnancy;Pregnancy Rate;Premature Birth;Prenatal care;prevent;Preventive healthcare;Primary Care;primary care setting;Process;Productivity;programs;Protocols documentation;Provider;Qualitative Methods;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;reproductive;Reproductive Health;reproductive health intervention;Research;Research Methodology;Research Personnel;Research Training;Risk;screening;sexual and reproductive health;skills;social;social health determinants;Spanish;Structural Racism;Structure;Surveys;Testing;therapy design;Training;Uninsured;unintended pregnancy;uptake;Visit;Woman;Women's Health

PROJECT_TITLE: Utilizing pediatric primary care connections to advance reproductive health

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE While prostate cancer is strongly influenced by inherited genetic factors, most genetic studies of prostate cancer have been limited to men of European ancestry, limiting our knowledge of genetic risk of prostate cancer in other populations. In this study, we will investigate genetic risk of prostate cancer in the All of Us Research Program across diverse populations, combining findings with previous large-scale prostate cancer genetic studies to strengthen our ability to identify novel genetic risk factors, and we will investigate whether genetic risk of prostate cancer can be modified by lifestyle and socioeconomic factors. We anticipate that findings from this investigation will improve our ability to identify men with increased risk of prostate cancer and aggressive disease, which could have important implications for screening and early detection of prostate cancer.

PI_NAMEs: DARST, BURCU FRANCES (contact)

PROJECT_TERMS: African;African American;African ancestry;All of Us Research Program;Asian population;BRCA2 gene;Cancer Etiology;Candidate Disease Gene;carrier status;Categories;Cessation of life;CHEK2 gene;Complex;cost;Data;Death Rate;Disease;disease-causing mutation;Disparity;East Asian;Economics;Education;European;European ancestry;exome;Genes;Genetic;Genetic Risk;genetic risk factor;Genetic study;genetic variant;Genetic Variation;genome sequencing;genome-wide;Genotype;Germ Lines;Goals;health care availability;health disparity;Healthcare;healthy lifestyle;Heritability;high risk men;Hispanic Populations;improved;Incidence;Indolent;Inherited;Investigation;Knowledge;Life Style;lifestyle factors;Malignant neoplasm of prostate;Malignant Neoplasms;man;Measures;men;Modeling;modifiable risk;mortality;non-genetic;novel;Obesity;Outcome;PALB2 gene;Pathogenicity;polygenic risk score;Population;Population Heterogeneity;Preventive measure;prostate cancer prevention;prostate cancer risk;rare variant;Relative Risks;Reporting;Research;Resources;Risk;Risk Factors;risk variant;Sample Size;screening;Screening for Prostate Cancer;Smoking Status;social;Socioeconomic Factors;unhealthy lifestyle;Variant;whole genome

PROJECT_TITLE: Germline Genetics and Risk of Prostate Cancer in Diverse Populations from the All of Us Program


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_CITY: SAN JUAN

ORG_NAME: COMPREHENSIVE CANCER CENTER/ UNIV/PR

ORG_STATE: PR

PHR: Project Narrative Cervical cancer incidence has increased among Puerto Rican women in recent years. This study will evaluate the impact of patient reminders, patient navigators, and self-collection on cervical cancer screening and follow- up care among Puerto Rican women. To inform the future broad-scale implementation of the effective approaches, we will also identify factors influencing the use of these strategies and determine their cost- effectiveness and budget impact.

PI_NAMEs: DESHMUKH, ASHISH A.;ORTIZ, ANA PATRICIA (contact)

PROGRAM_OFFICER_NAME: CHOLLETTE, VERONICA

PROJECT_TERMS: acceptability and feasibility;Address;Adoption;Age;arm;budget impact;Caring;Cervical;cervical cancer prevention;Cervical Cancer Screening;Clinic;Clinical;cohort;Collection;Colposcopy;Communities;cost effective;cost effectiveness;Diagnosis;Diagnostic Reagent Kits;Disasters;Disparity;Distant;Early Diagnosis;Effectiveness;effectiveness evaluation;effectiveness/implementation study;Eligibility Determination;Evaluation;Event;follow-up;Future;Goals;Government;Home;home test;Human Papillomavirus;Hybrids;Hysterectomy;implementation evaluation;implementation outcomes;improved;Incidence;Individual;interest;Intervention;Intervention Studies;Interview;Island;Knowledge;Low income;Maintenance;Malignant neoplasm of cervix uteri;Malignant Neoplasms;mathematical model;Medicaid;Medicare;Minority Women;models and simulation;Morbid Obesity;mortality;multi-component intervention;multidisciplinary;Natural History;Obesity;Pap smear;patient navigation;patient navigator;Patients;Population;Population Study;premalignant;President's Cancer Panel;Provider;Puerto Rican;Puerto Rico;Randomized, Controlled Trials;Recovery;Sampling;screening;screening participation;Screening Result;secondary analysis;secondary outcome;self testing;Site;Squamous intraepithelial lesion;success;Testing;Transportation;Treatment outcome;trend;United States;uptake;Visit;Woman;women's outcomes;women's treatment;Work;World Health Organization

PROJECT_TITLE: The effectiveness, cost-effectiveness, and budget impact of interventions to improve the delivery of cervical cancer screening in Puerto Rico.

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Patient Safety;Substance Misuse

ORG_DEPT: GENETICS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE People who inject drugs are susceptible to being hospitalized with severe bacterial and fungal infections but may not receive evidence-based treatment for substance use disorder in the hospital. Using national Medicaid data and qualitative methods, we will study how addiction treatments are delivered to people hospitalized with injection-related infections, how those treatments are related to clinical outcomes, and how to improve the addiction-related healthcare for this population.

PI_NAMEs: KAPADIA, SHASHI  (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: Abscess;access disparities;addiction;Address;Affect;Antibiotics;Area;Attitude;Bacterial Infections;Behavior Therapy;Caring;Cessation of life;Clinical;Consultations;cost;Data;design;Disparity;Drug user;economic outcome;Effectiveness;Endocarditis;Ethnic Origin;evidence base;Evidence based treatment;experience;follow-up;Gender;Health;Health Care Costs;health care delivery;Health Care Sector;health care service utilization;Health Services;Healthcare;Hepatitis C;Hispanic;hospital readmission;Hospitalization;Hospitals;improved;improved outcome;indexing;Infection;infection risk;Injecting drug user;injection drug use;Injections;Inpatients;Institution;Insurance Carriers;interest;Intervention;intervention delivery;Interview;Knowledge;Length of Stay;Measures;Medicaid;medical specialties;medication for opioid use disorder;member;men;Methods;mortality;Mycoses;Operative Surgical Procedures;Osteomyelitis;Outcome;Outpatients;Patient Admission;Patients;Persons;Policies;Population;Positioning Attribute;Predisposition;programs;Provider;Public Health;Qualitative Methods;Race;recruit;recurrent infection;Sampling;Severities;Spinal;Substance Use Disorder;substance use treatment;System;theories;Training;Training Programs;treatment and outcome;treatment disparity;treatment program;United States;uptake;Urbanicity;Variant

PROJECT_TITLE: Delivery of Addiction Treatment for Medicaid Enrollees with Serious Injection-Related Infections


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Otitis Media;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Narrative As a society, we have long recognized the significant risk for language delays facing children born into poverty. Research efforts to understand this risk have appropriately focused on social determinants such as parental interaction styles, parental stress, and parental knowledge of child development, but those factors have never been able to fully account for the problem. This project expands our search for explanatory factors by proposing that poverty-related healthcare inequities put children at risk for premature birth and more-frequent otitis media with effusion, and these biological factors, in turn, delay development of essential auditory skills needed to acquire language on a typical timetable.

PI_NAMEs: NITTROUER, SUSAN  (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: 8 year old;Acoustics;Address;Affect;Age;Auditory;Auditory system;Biological;Biological Factors;Birth Weight;Black race;Buffers;Categories;Child;Child Development;child poverty;Child Rearing;Childhood;Chronic;Code;Complex;Cues;deaf;Development;effusion;Endogenous Factors;Exogenous Factors;experience;Face;Friends;Gestational Age;Goals;Growth;Health;health care disparity;hearing impairment;Human;Impairment;Incidence;innovation;Institutional Racism;Knowledge;Laboratories;Language;Language Delays;Language Development;Language Disorders;Learning;lexical;Linguistics;Measures;Medical;Methodology;Mind;Minor;Minority;Modeling;Mothers;novel;Otitis Media with Effusion;Outcome;Parent-Child Relations;Parents;Participant;Performance;Perinatal;Peripheral;phonology;postnatal;Poverty;premature;Premature Birth;Process;Recording of previous events;Research;Risk;Risk Factors;Scientist;Severities;Signal Transduction;skills;social;social determinants;social factors;Societies;Socioeconomic Status;socioeconomics;Source;Stress;Structural Racism;Structure;supportive environment;Testing;Time;War;Work

PROJECT_TITLE: Poverty-Related Risk Factors for Auditory and Language Deficits in Children

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-H(02)M]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE This project is relevant to public health because it explains how light regulates early photoreceptor development in the eye. This work has implications for human health because it may provide a way to predict and treat eye disorders with light stimulation therapy.

PI_NAMEs: LANG, RICHARD A. (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Adult;Amaze;Apoptosis;Birth;Blood Vessels;Cell Death;Cessation of life;Cone;dark rearing;Data;Dendrites;design;Development;Developmental Process;Environment;Etiology;experience;Eye;Eye Development;Eye diseases;G alpha q Protein;genetic approach;Glutamate Receptor;glutamatergic signaling;Glutamates;GTP-Binding Proteins;Health;Human;interest;intimate behavior;Label;Light;Link;loss of function;Mediating;melanopsin;Mus;Neonatal;Neuromodulator;novel;organ growth;Pathway interactions;Pattern;Perinatal;Photoreceptors;postnatal;precursor cell;prevent;Process;progenitor;Public Health;Recording of previous events;response;Retina;Retinal Ganglion Cells;retinal neuron;Retinal Photoreceptors;retinal rods;Rod;sensor;Sensory;single cell analysis;single cell sequencing;Structure;Study models;Systems Development;Testing;Time;vision development;Visual;Visual System;Work

PROJECT_TITLE: Melanopsin-dependent light-evoked development of rod photoreceptors

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: PROJECT NARRATIVE Allostatic load (AL) is a complex clinical construct that offers a unique window into the cumulative toll of stress and how it manifests as physiological and psychological dysfunctions. This proposed study will leverage the Asian American (AA) subsample from the All of Us Research Program to understand the cumulative toll of chronic stress through the concept of AL, its behavioral and social-contextual correlates, and how AL manifests as chronic diseases among AAs, in aggregate and by four regional/ethnic subgroups (East Asian, Southeast Asian, South Asian, and Filipino Americans). Through dissemination activities jointly led by the researchers and community/clinical stakeholders, we expect the findings of this study will guide future lifestyle and behavioral interventions to improve resilience and provide clinical implications for personalized medicine to mitigate stress and prevent chronic diseases in understudied AAs.

PI_NAMEs: ZHU, LIN  (contact)

PROGRAM_OFFICER_NAME: BICKHAM-WRIGHT, UTIBE RONALD

PROJECT_TERMS: Acculturation;Age;age acceleration;Alcohol consumption;All of Us Research Program;allostatic load;American;anti-Asian;Anxiety;Asian;Asian Americans;Asian Indian;Behavior;Behavior Therapy;Behavioral;Biomedical Research;Body mass index;built environment;burden of illness;Cambodian;cancer risk;cardiometabolism;Cardiovascular Diseases;Chinese;Cholesterol;Chronic;Chronic Disease;Chronic lung disease;Chronic stress;Clinical;Cluster Analysis;cohesion;Communities;Complex;contextual factors;Coronary heart disease;Country;Data;demographics;Diabetes Mellitus;Discrimination;disorder prevention;Disparity population;Drug Use Disorder;East Asian;Education;Endocrine;Ethnic Origin;Ethnic Population;Filipino;Filipino American;Functional disorder;Future;Growth;Hate;Health;Health behavior;health equity;Healthcare Systems;Heterogeneity;high risk;high risk population;Hypertension;Hypothyroidism;Immigrant;Immune system;Impaired cognition;improved;Income;Intervention;Japanese;Knowledge;Koreans;lens;Life;Life Style;lifestyle intervention;Limited English Proficiency;Link;Literature;Lived experience;Logistic Regressions;Loneliness;Malignant neoplasm of liver;Malignant Neoplasms;Marital Status;Mediating;Mediation;Medical;men;Mental Depression;Mental disorders;Metabolic;Minority;Modeling;Morbidity - disease rate;multiple chronic conditions;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;Pakistan;Pathway interactions;Pattern;Peripheral Vascular Diseases;personalized medicine;Physiological;Population;Precision Health;precision medicine;prevent;Principal Component Analysis;promote resilience;psychologic;Race;racial diversity;racial population;racism;Reduce health disparities;Refugees;Research;Research Personnel;Risk;Sampling;Scientific Advances and Accomplishments;sex;Smoking;Social Behavior;Social Environment;Social support;sociodemographics;Socioeconomic Status;South American;South Asian;southeast Asian;Stress;Stroke;Subgroup;System;Tobacco use;Trauma;Variant;Vietnamese

PROJECT_TITLE: Linking Social-Behavior Contextual Factors and Allostatic Load to Chronic Diseases in Diverse Asian Americans: A Socioecological Approach to Advancing Precision Medicine and Health Equity


NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Neurosciences;Regenerative Medicine;Rehabilitation;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stroke

ORG_CITY: ATLANTA

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: EMORY UNIVERSITY

PHR: Ischemic stroke is a leading cause of human death and long term disability. We propose to investigate a novel strategy to direct reprogramming endogenous non-neuronal cells into neurons that can gain a balanced microenvironment for cell survival and regeneration in the post-ischemic brain. Comprehensive approaches including cellular, molecular, optogenetics, electrophysiological techniques will be tested in aged male, female mice to promote and verify regenerative repair and functionalities after ischemic stroke.

PI_NAMEs: WEI, LING  (contact);YU, SHAN P.

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Affect;Age;aged;aging brain;animal old age;Area;Astrocytes;astrogliosis;Attention;Autologous;axon growth;behavior test;Blood Vessels;Brain;Brain Hypoxia-Ischemia;Brain Ischemia;brain repair;Bypass;Cell Death;Cell Proliferation;cell regeneration;Cell Survival;Cell Transplantation;Cells;Cerebral Ischemia;Cessation of life;Chemicals;chemokine;Cicatrix;Clinical Trials;combinatorial;cytokine;Data;delivery vehicle;design;Deterioration;direct application;disability;Ectopic Expression;efficacy validation;Electrophysiology (science);enhancing factor;experimental study;Face;Female;Gene Expression;Genes;Glial Fibrillary Acidic Protein;Graft Rejection;Homing;Human;human mortality;human old age (65+);Impairment;In Vitro;in vivo;Induced Neurons;Infarction;Inflammatory;Injury;Investigation;Ischemia;Ischemic Stroke;Lentivirus;Lentivirus Vector;Long term disability;male;Measures;Microglia;migration;Molecular;Morphology;mortality;mouse model;Mus;Natural regeneration;Nerve Regeneration;nerve stem cell;neural network;neurogenesis;Neuroglia;Neuronal Plasticity;Neurons;neuroprotection;novel;novel strategies;novel therapeutic intervention;old mice;optogenetics;Pathway interactions;Patients;Peripheral;permissiveness;post stroke;postmitotic;Process;programs;Proliferating;promoter;Recovery of Function;regeneration function;regenerative;regenerative approach;regenerative repair;Regenerative research;regenerative therapy;Rehabilitation therapy;release factor;repaired;Reperfusion Therapy;Resources;restraint;Risk;Signal Transduction;Site;Source;stem cells;Stroke;stroke model;stroke patient;stroke therapy;Techniques;Technology;Testing;Therapeutic;Therapeutic Studies;Time;timeline;tissue repair;Tissues;transcription factor;Transplantation;tumorigenesis;Vibrissae

PROJECT_TITLE: Direct Reprogramming of the brain after ischemic stroke in the aged mouse

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Hematology;Immunization;Immunotherapy;Orphan Drug;Rare Diseases

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE T-cell directed therapies are the most exciting recent advances in treatment of patients, but after the initial response patients inevitably relapse to this disease and myeloma remains incurable. We will credential a mouse model for developing novel combinations of drugs with T-cell directed treatments which will allow for their rapid clinical development. These studies will likely inform clinical practice on how combine standard of care agents with immunotherapy.

PI_NAMEs: BERGSAGEL, PETER LEIF;CHESI, MARTA  (contact)

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: Affect;Alkylating Agents;Antibodies;Antibody Therapy;Antigens;Biological Models;Bispecific Antibodies;Bite;Bone Marrow;Bortezomib;Cancer Therapy Evaluation Program;CAR T cell therapy;CD3 Antigens;Cell Physiology;Cells;chimeric antigen receptor T cells;Clinical;clinical development;clinical practice;clinical predictors;Clinical Trials;clinically relevant;co-clinical trial;Combined Modality Therapy;Complex;conventional therapy;cost;Credentialing;Cyclophosphamide;cytokine release syndrome;cytotoxic;Cytotoxic T-Lymphocytes;Data;design;Development;Dexamethasone;Disease;Disease remission;DNA;exhaust;exhaustion;Extramedullary;genomic profiling;Glucocorticoids;Harvest;Hematopoietic Neoplasms;Human;Immune;Immune checkpoint inhibitor;immune modulating agents;Immune system;Immunocompetent;immunodeficiency;Immunologics;Immunooncology;Immunotherapy;improved;In complete remission;lenalidomide;leukemia/lymphoma;Long-Term Effects;Longitudinal Studies;Malignant - descriptor;Mediating;Melphalan;Modeling;mouse model;Multiple Myeloma;Mus;neoplastic cell;novel drug combination;patient response;Patient-Focused Outcomes;Patients;Phase;Phase II Clinical Trials;Plasma Cells;pomalidomide;pre-clinical;preclinical study;Prednisone;Proteasome Inhibitor;Randomized;receptor;reconstitution;Refractory;Relapse;relapse patients;Reporting;Research Personnel;Resistance;response;retransplantation;Shapes;single-cell RNA sequencing;standard of care;Surface Antigens;T cell therapy;T-Cell Activation;T-Lymphocyte;targeted treatment;Thalidomide;TNFRSF17 gene;tool;Toxic effect;Transgenes;treatment response;tumor;Tumor Burden;Tumor Debulking;tumor microenvironment;tumor-immune system interactions;Validation;Vertebral column;Xenograft Model

PROJECT_TITLE: preclinical optimization of BCMA directed T cell therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-E(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Diabetes;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Menopause;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: Project Narrative The goal of the proposed project is to identify how sex-hormones, inflammation, and obstructive sleep apnea impact the relationship between brain tissue oxygen use and functional impairment in middle-aged underrepresented women with Type 2 Diabetes (DM). Underrepresented women experience the most severe long-term consequences of DM, including development of vascular dementia; however, we have limited insight into the complex causes of poor brain health in this population. This project will advance understanding of brain health as a combined effect of sex-hormone changes, inflammation, and obstructive sleep apnea in underrepresented women with DM prior to development of vascular dementia.

PI_NAMEs: GORNIAK, STACEY LYNN (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Adult women;Age;aged;Area;Biological Availability;Biological Markers;Biometry;Body mass index;brain health;brain tissue;C-reactive protein;Characteristics;Cholesterol;Chronic;Cognitive;cognitive function;Communities;comparison control;Complex;Control Groups;Development;Endocrinology;Equation;Estrogens;ethnic minority population;Ethnic Population;Event;evidence base;experience;Functional impairment;functional near infrared spectroscopy;Goals;Gonadal Steroid Hormones;Health;health disparity;heart disease prevention;Heart Diseases;Hematological Disease;High Risk Woman;Hypoxemia;Impairment;indexing;Individual;Inflammation;inflammatory marker;insight;interest;Knowledge;Link;Lung Diseases;Measurement;Measures;Mediating;Mediation;Menopause;middle age;Midlife women;Minority Status;Modeling;National Heart, Lung, and Blood Institute;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;Obstructive Sleep Apnea;Outcome;Output;Oxygen;Oxyhemoglobin;Pathogenesis;Pathway interactions;Perimenopause;Persons;Play;poor sleep;Population;Postmenopause;Pulmonology;racial minority population;racial population;Recording of previous events;recruit;Reporting;Risk;Risk Factors;Role;Sensorimotor functions;Severities;sex;Sleep;Sleep Apnea Syndromes;Sleep Deprivation;Sleep Disorders;sleep health;sleep quantity;Testosterone;tissue oxygenation;Tissues;Underrepresented Minority;Vascular Dementia;Woman;Women's Health;Work

PROJECT_TITLE: Cortical Complications of Perimenopause and Obstructive Sleep Apnea in Underrepresented Middle-Aged Women with Type 2 Diabetes

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Social Determinants of Health;Tuberculosis

ORG_CITY: MBARARA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: MBARARA UNIVERSITY/SCIENCE/ TECHNOLOGY

PHR: Contact PI (Last, First, Middle): Musiimenta, Angella PROJECT NARRATIVE TB is a serious public health concern which kills more people annually than HIV and malaria combined, and poor treatment adherence limits the success of TB treatment and increases TB transmission. SMS texts and real-time adherence monitoring may provide low-cost and acceptable alternative approaches to supporting TB medication especially in settings where DOT is difficult to implement, while incentives may overcome financial and motivational issues that currently constrain medication adherence. My Mobile Wallet is a novel intervention that utilizes SMS texts to remind medication adherence, and utilize mobile money-based approaches to provide transport to the clinic, and motivate medication adherence.

PI_NAMEs: MUSIIMENTA, ANGELLA  (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adoption;Adult;arm;Behavioral;behavioral economics;Behavioral Sciences;Caring;Cellular Phone;Client;Clinic;Clinical;Consumption;cost;Country;design;drug-sensitive;Economics;electronic adherence monitoring;Ensure;Environment;Face;Financial Hardship;financial incentive;Financial Support;Focus Groups;follow-up;Future;Geography;Grant;Health Services Accessibility;Health Technology;HIV;Hospital Referrals;improved;Incentives;Incidence;Income;Individual;Infrastructure;innovation;Intervention;Interview;Low income;Madagascar;Malaria;Maternal Health Services;Measures;medication compliance;mHealth;Monitor;mortality;Motivation;Newly Diagnosed;Notification;novel;Outcome;Patient Recruitments;Patients;Persons;Pharmaceutical Preparations;pilot test;Prevalence;Public Health;public health priorities;Randomized;Randomized, Controlled Trials;real time monitoring;Research;Research Personnel;Review Literature;Rural;Services;Site;social engagement;Social support;success;System;Technology;Testing;theories;Time;transmission process;Travel;treatment adherence;treatment duration;Tuberculosis;Tuberculosis diagnosis;tuberculosis treatment;Uganda;usability

PROJECT_TITLE: My Mobile Wallet: An Intervention to Support Access to Tuberculosis Care and Medication Adherence in Rural Uganda


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Substance Misuse

ORG_CITY: SYRACUSE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: SYRACUSE UNIVERSITY

PHR: Project Narrative Posttraumatic stress disorder (PTSD) frequently co-occurs with harmful alcohol use and alcohol use disorder, conferring unique etiological risks for drinking and challenges to successful alcohol treatment. The proposed research will identify affectively-linked cognitions that lead to problem drinking in-the-moment as drinkers experience PTSD symptoms in their real-world settings. Such acute cognitive mechanisms represent key, proximal clinical targets that could be modified through future just-in-time adaptive interventions in an effort to reduce the harms of PTSD-related drinking.

PI_NAMEs: ZASO, MICHELLE JOSEPHINE (contact)

PROGRAM_OFFICER_NAME: ZHA, WENXING

PROJECT_TERMS: Acute;Acute Post Traumatic Stress Disorder;adaptive intervention;addiction;Address;Affective;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol expectancy;alcohol measurement;alcohol use disorder;Alcohols;Area;Award;career;career development;Clinical;Cognition;Cognitive;cognitive interview;cognitive process;cognitive testing;Collaborations;coping;Data;Dedications;design;Development;Distress;distress tolerance;drinking;Ecological momentary assessment;Emotional;Emotions;Environment;Etiology;Event;evidence base;experience;field study;Focus Groups;Frequencies;Future;Grain;Group Interviews;Harm Reduction;Hour;Individual;innovation;Intervention;Investigation;Knowledge;Laboratories;Link;Maps;Measurement;Measures;Mediating;Mentorship;Methodology;Methods;Modeling;multilevel analysis;negative affect;neglect;novel;Outcome;Pathway interactions;Patient Self-Report;Phase;Post-Traumatic Stress Disorders;Process;Productivity;programs;Psychology;Public Health;Reporting;Research;Research Institute;Research Personnel;Risk;Role;Schedule;skills;Source;Statistical Models;Survivors;Symptoms;Techniques;Testing;Time;Translations;Trauma;Treatment outcome;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Identification and characterization of in-the-moment cognitive antecedents to alcohol use among drinkers with PTSD

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetic Testing;Genetics;Precision Medicine;Prostate Cancer;Urologic Diseases

ORG_CITY: SEATTLE

PHR: PROJECT NARRATIVE The proposed research will establish new biomarkers to classify prostate cancer subtypes from the blood and to predict responses to a new generation of treatments. The strategy will provide a cost-effective and non- invasive view of how prostate cancer heterogeneity/variation influences therapy resistance. This research will lead to new molecular diagnostics that will improve the lives and outcomes for patients with prostate cancer.

PI_NAMEs: HA, GAVIN  (contact);NELSON, PETER S

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Address;Adenocarcinoma;Adoption;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Autopsy;Biological Markers;Biopsy;Blood;Blood specimen;blood treatment;BRCA2 gene;Breast Carcinoma;cancer classification;Cancer Etiology;cancer heterogeneity;Cancer Patient;cancer subtypes;Categories;Cell Cycle;cell free DNA;Cessation of life;Characteristics;Classification;Clinical;clinically relevant;cost effective;curative treatments;Detection;DNA analysis;DNA Sequence Alteration;DNA sequencing;Engineering;Evolution;Exhibits;FDA approved;fluorodeoxyglucose positron emission tomography;FOLH1 gene;Frequencies;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic Transcription;Genomics;Genotype;Heterogeneity;Histology;improved;improved outcome;in vivo;Individual;inhibitor;inhibitor therapy;innovation;Inter-tumoral heterogeneity;liquid biopsy;Lung Carcinoma;Malignant neoplasm of prostate;Malignant Neoplasms;medicine man;men;Methods;Molecular;molecular diagnostics;molecular subtypes;Monitor;Morbidity - disease rate;mortality;Mus;Neoplasm Metastasis;neoplastic cell;Neuroendocrine Cell;neuroendocrine differentiation;Neuroendocrine Prostate Cancer;Nucleosomes;Oncogenes;Outcome;patient derived xenograft model;patient screening;patient subsets;Patient-Focused Outcomes;Patients;Pattern;Performance;Phenotype;Plasma;Positron-Emission Tomography;potential biomarker;pre-clinical;precision medicine;predicting response;Prediction of Response to Therapy;predictive marker;pressure;Procedures;Prognosis;Prognostic Marker;Proliferating;Prospective cohort;Prostate Adenocarcinoma;Prostate Cancer therapy;radiation resistance;radioligand;RB1 gene;Receptor Signaling;Research;Research Personnel;Resistance;Resistance development;response;Sampling;Selection for Treatments;Signal Transduction;Site;Small Cell Carcinoma;standard of care;targeted treatment;Testing;Therapeutic;therapy outcome;therapy resistant;Time;Tissues;tool;TP53 gene;Transcriptional Regulation;transdifferentiation;Treatment outcome;treatment response;treatment strategy;tumor;tumor diagnosis;tumor DNA;tumor heterogeneity;Tumor Subtype;Tumor Suppressor Proteins;Variant

PROJECT_TITLE: Evaluating prostate cancer phenotype and genotype classification from circulating tumor DNA as biomarkers for predicting treatment outcomes

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Neurosciences;Substance Misuse

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: NARRATIVE This research project investigates a little-studied modality of glucocorticoid signaling and its potential recruitment in the brain during withdrawal from chronic excessive alcohol drinking. This work will enhance our understanding of the mechanism of action of glucocorticoid receptor antagonists in the context of alcohol use disorders.

PI_NAMEs: CONTET, CANDICE  (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Abstinence;Affect;Agonist;Air;alcohol abuse therapy;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol exposure;alcohol prevention;alcohol seeking behavior;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;antagonist;Astrocytes;Attention;Automobile Driving;behavior test;Binding;Bioinformatics;Brain;Brain region;cell type;Chromosome Mapping;Chronic;Code;cohort;Complex;Corticosterone;Cultured Cells;Cytoplasm;Dexamethasone;Down-Regulation;Endoribonucleases;Ethanol;Functional disorder;Gene Expression;genetic manipulation;Genetic Transcription;Glucocorticoid Receptor;glucocorticoid-induced orphan receptor;Glucocorticoids;Heavy Drinking;human subject;Hyperactivity;Impaired cognition;Inhalation;knock-down;Ligand Binding;Ligands;Location;male;Medial;Mediating;Memory;Memory impairment;Mental disorders;Messenger RNA;Mifepristone;Modality;Modeling;Molecular;molecular targeted therapies;Motivation;mRNA Decay;Mus;Nervous System Disorder;novel;object recognition;pharmacologic;Play;Prefrontal Cortex;prevent;Primates;Process;Proteins;Proteomics;Receptor Activation;Receptor Inhibition;Receptor Signaling;Recording of previous events;recruit;Reproducibility;Research Project Grants;Resources;RNA Interference;Rodent;Role;Sampling;sex;Signal Transduction;small hairpin RNA;Specificity;Testing;Therapeutic;Time;Transcript;transcription factor;transcriptome sequencing;transcriptomics;Up-Regulation;vapor;Water;Withdrawal;Work

PROJECT_TITLE: Role of glucocorticoid receptor-mediated mRNA decay in alcohol dependence

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]