NIH_SPENDING_CATS: Aging;Brain Disorders;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Neurosciences

PHR: Project Narrative As the most common genetic developmental disorder that leads to intellectual disability, people with Down syndrome have several health challenges that impact their quality of life. This application requests funding to cover travel expenses of American-based junior investigators, postdoctoral fellows and graduate students to attend the Fifth International conference of the Trisomy 21 Research Society (T21RS). This conference will lead to fruitful discussions and novel collaborations that are essential to define the future of DS research. The theme of our meeting will be Promoting Research Experience in Down syndrome.

PI_NAMEs: HEAD, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Address;Advocate;Aging;Alzheimer's Disease;American;Applied Research;Area;Award;Basic Science;Behavioral;Brain;career;Chicago;Chromosome 21;Clinical Research;Clinical Trials;Cognition;Cognitive;Cognitive deficits;Collaborations;Communication;comorbidity;Defect;Dementia;design;developmental disease;developmental genetics;Down's Syndrome;effective therapy;experience;Family;Funding;Future;Genetic;Goals;graduate student;Health;high risk;improved;Individual;innovation;Intellectual functioning disability;Intellectual impairment;interest;International;Investigation;Italy;Journals;Knowledge;knowledge base;Laboratories;life span;meetings;middle age;nano;Nerve Degeneration;neuron development;neuropathology;next generation;novel;pandemic disease;Paris, France;pathological aging;Persons;Postdoctoral Fellow;posters;programs;Quality of life;Request for Applications;Research;Research Personnel;Rome;Schedule;Scientist;Senior Scientist;Societies;Spain;Structural defect;success;symposium;therapeutic target;Training and Education;Translating;translational potential;Translational Research;Travel;United States National Institutes of Health;virtual

PROJECT_TITLE: T21RS Meeting June 2024 Rome, Italy

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


ADMINISTERING_IC: HD

ARRA_FUNDED: N

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: EUGENE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: PROJECT NARRATIVE: Human bone repair is limited to relatively small fractures. In contrast, zebrafish rapidly and reliably regenerate fins including reestablishing an intricate bony ray skeleton. Uncovering the mechanisms underlying this robust skeletal patterning will support novel regenerative medicine approaches for bone damage and disease.

PI_NAMEs: HORST, SAMUEL G (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Adhesions;Adult;Antibodies;Behavior;blastema;bone;bone repair;Candidate Disease Gene;Cell Adhesion;cell behavior;Cell Communication;Cells;Cellular biology;Characteristics;Communication;CRISPR screen;Custom;Data;Data Set;Daughter;Defect;Development;Developmental Biology;Disease;Distal;Doctor of Philosophy;Epidermis;fibrillin;Fibroblasts;Fishes;Fracture;Genes;Germ Lines;Goals;Human;Image;imaging approach;Individual;Injury;insight;Integrins;Intubation;Length;Limb structure;Mediating;Mediator;Mentorship;Methods;Microfibrils;migration;Morphogenesis;Movement;mutant;Mutate;Natural regeneration;novel;osteoblast proliferation;Osteoblasts;Outcome;Pathway interactions;Pattern;Population;Positioning Attribute;prevent;progenitor;Proteins;Protocols documentation;Publishing;Regenerative Medicine;Reporter;Reporter Genes;Research;scaffold;Science;SHH gene;Signal Transduction;single-cell RNA sequencing;skeletal;skeletal disorder;skeletal injury;Skeleton;skills;small molecule;small molecule inhibitor;smoothened signaling pathway;Stains;Structure;Swimming;System;Tenascin;Time;Tissues;Training;Transcript;transcriptome sequencing;Transgenic Organisms;Visualization;Zebrafish

PROJECT_TITLE: Sonic hedgehog signaling and skeletal patterning during zebrafish fin regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cannabinoid Research;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Natural Products;Neurosciences;Opioid Misuse and Addiction;Opioids;Prescription Drug Misuse;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: PORTLAND

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: Project Narrative The recent surge in the use of the highly-potent synthetic opioid fentanyl has exacerbated the opioid epidemic and underscores a significant public health crisis. A potential therapeutic target for opioid use disorder lies in cannabinoid receptors, which are co-expressed with opiate receptors in the brain's reward centers and modulate opiate-associated behaviors. This proposal aims to use chemical biology to investigate cannabinoid- opiate interactions, which will pave the way for new therapeutic strategies in the fight against the intensifying opioid crisis.

PI_NAMEs: FRANK, JAMES ALLEN (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Acute;addiction;Antibodies;Behavior;Biology;Brain;cannabinoid receptor;Cannabinoids;Chemicals;CNR1 gene;CNR2 gene;Collaborations;Compensation;Data;Development;experimental study;Fentanyl;fighting;Fluorescent Probes;fluorophore;Genetic;Goals;GPR55 receptor;Heroin;Hydrophobicity;in vivo Model;innovation;Kinetics;Knock-out;Label;Ligands;live cell imaging;Microinjections;Molecular;Neurobiology;next generation;novel therapeutic intervention;novel therapeutics;Opioid;opioid epidemic;opioid mortality;Opioid Receptor;opioid use disorder;Optics;Pharmacologic Substance;prescription opioid misuse;Public Health;Publishing;receptor;Resolution;Review Literature;Rewards;Role;Signal Pathway;Signal Transduction;spatiotemporal;Stimulus;Substance Use Disorder;synthetic opioid;System;Technology;temporal measurement;therapeutic target;Time;tool;United States;Ventral Tegmental Area

PROJECT_TITLE: Chemical biology tools for illuminating cannabinoid signaling pathways in opioid use disorder.

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 MXS-M (M1)]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: SEATTLE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Complex, black-box machine learning (ML) models have become standard tools in biomedical inquiry and clinical medicine, and their opaque nature and consequent lack of interpretability gave rise to transformative explainable AI (XAI) techniques. However, due to fundamental limitations, current XAI techniques provide only a partial explanation of inner workings of clinical ML models. This project aims to address these challenges by developing novel general XAI frameworks for medically relevant and computationally rigorous interpretation of clinical AI models and applying them to skin disease as an example.

PI_NAMEs: LEE, SU-IN  (contact)

PROGRAM_OFFICER_NAME: PEREIRA DE SA, RUI CARLOS

PROJECT_TERMS: Address;Adoption;Algorithms;artificial intelligence model;beneficiary;Biomedical Research;Black Box;Clinical;clinical application;clinical imaging;Clinical Medicine;Complex;cost;deep learning;deep neural network;Dermatologic;Dermatology;Detection;Device Safety;Devices;Diagnosis;Diffusion;Ensure;Evaluation;explainable artificial intelligence;Foundations;Handedness;Healthcare;Human;Image;Impairment;improved;Individual;insight;interest;Label;large language model;Learning;Lesion;Linear Models;Literature;Lung;machine learning model;Manuals;Measures;Medical;Medical Device;Medical Imaging;Melanoma;Methodology;Methods;Modeling;Modernization;Monitor;Morphologic artifacts;multimodal data;multimodality;Nature;novel;Oral;Output;Pathology;Patients;Physicians;post-market;Process;Provider;real world application;Research;Research Personnel;response;responsible artificial intelligence;Safety;Scientist;self supervised learning;Semantics;Skin;skin disorder;Specific qualifier value;stakeholder perspectives;Stress Tests;Techniques;Testing;Text;theories;Thoracic Radiography;Time;tool;Training;training data;Trees;Trust;Validation;Weight;X-Ray Medical Imaging

PROJECT_TITLE: XAI-TRUST: Explainable AI Techniques to Rigorously Understand, Scrutinize, and Trust Clinical AI

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Chronic Pain;Hematology;Neurosciences;Pain Research;Rare Diseases;Sickle Cell Disease

ORG_CITY: MILWAUKEE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative: Patients with sickle cell disease (SCD) suffer from severe acute and chronic pain, the exact causes of which are unknown. We will determine whether free heme drives steady state pain and whether the cytokine TNFα drives acute vaso-occlusive episodic pain by sensitizing sensory neurons through direct and immune-mediated inflammatory signaling. If our studies are positive, they will suggest that TNFα inhibitors which are FDA- approved should be tested in clinical trials with SCD patients.

PI_NAMEs: DITTEL, BONNIE N;STUCKY, CHERYL LOUISE (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: 3-Dimensional;Absence of pain sensation;Acute;Acute Pain;addiction;Adult;Affect;Afferent Neurons;American;Ankylosing spondylitis;Antibodies;Arthritis;Attenuated;Behavioral;Binding;Black race;Blood;Blood Cells;Blood Circulation;Caring;cell injury;Cell Line;Cells;Chronic;chronic pain;Clinical;Clinical Trials;Complication;Cutaneous;cytokine;cytotoxicity;Data;Disease;disease model;Emergency Care;Event;experience;FDA approved;Fibromyalgia;Foundations;Genes;Genetic Transcription;Haptoglobins;Heme;heme-binding protein;Hypersensitivity;Immune;immune cell infiltrate;improved;Individual;Induced Neurons;infancy;Inflammation;Inflammatory;Inflammatory Bowel Diseases;infliximab;Knowledge;life span;Link;Macrophage;Mechanics;Mediating;metabolomics;mouse model;Mus;Neurons;neutrophil;new therapeutic target;Nociception;Opioid;opioid therapy;Pain;pain behavior;Patients;Persistent pain;Plasma;pre-clinical;prescription opioid;Psoriasis;recruit;Recurrence;Reporter;Risk;Role;Rupture;Sickle Cell;Sickle Cell Anemia;side effect;Signal Transduction;single-cell RNA sequencing;Slipped Disk;Spinal;Spinal Ganglia;Testing;TLR4 gene;TNF gene;Transcend;Translations;TRPV1 gene;tumor necrosis factor-alpha inhibitor;Underserved Population;Wild Type Mouse

PROJECT_TITLE: Nociceptive Mechanisms Underlying Sickle Cell Pain

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: TORRANCE

ORG_NAME: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER

ORG_STATE: CA

PHR: Project Narrative This R13 application requests funds to support the XXVIIth North American Testis Workshop to be held on May 2-5, 2024, at the Embassy Suites in Denver, Colorado. The proposed meeting aims to bring together leading experts and trainees in the field of testis biology from North America and around the world to present and discuss their latest data and technologies that could lead to resolving important medical and public health issues.

PI_NAMEs: YAN, WEI  (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Affect;American;Androgens;Andrology;Automobile Driving;biological systems;Biology;Brain;Cardiovascular Diseases;cardiovascular health;career;career networking;Cellular biology;Characteristics;Chemicals;Child;Clinical;clinical application;Collaborations;Colorado;cost;Data;Dedications;Development;Disabled Persons;DNA;Educational workshop;egg;Elements;Embryo;Ensure;epigenome;epigenomics;ethnic minority;Faculty;Feedback;Fertilization;Fostering;Funding;Genetic;Genome;Genomics;Germ Cells;Goals;Gonadal structure;graduate student;grandchild;Growth;Health;Heart;Histones;Hormones;Housing;insight;International;Knowledge;Life;Liver;Location;Maintenance;male;Male Genital Organs;male health;Male Infertility;Malignant Neoplasms;Medical;meetings;Metabolic syndrome;Modification;Molecular Biology;neuron development;new technology;North America;novel;offspring;Organ;peer;Physiology;Postdoctoral Fellow;Production;programs;Public Health;racial minority;Regulation;reproductive fitness;reproductive system disorder;Request for Applications;Research;Research Personnel;Scientist;single cell technology;Societies;sperm cell;Spermatogenesis;Technology;Testis;Testosterone;Translations;Travel;Underrepresented Populations;Untranslated RNA;Women's Group;Work;zygote

PROJECT_TITLE: Celebrating the Inspired and Inspiring Testis Biology- The XXVII North American Testis Workshop

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Despite widespread vaccination in the United States, pertussis (whooping cough) can be life-threatening for infants and young children. Pertussis is caused by the bacterium Bordetella pertussis and the virulence factor pertussis toxin (PT) is responsible for many of the disease symptoms. This proposal aims to characterize the molecules that PT recognizes in order to enter human cells and cause disease. Project Narrative

PI_NAMEs: KOHLER, JENNIFER J (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Acids;ADP ribosylation;Affect;Affinity;airway epithelium;Bacteria;Binding;Biological Assay;Bordetella pertussis;Cell Culture Techniques;Cell Line;Cell surface;Cell Surface Receptors;cell type;Cells;Cellular Structures;chemokine;Child;Clustered Regularly Interspaced Short Palindromic Repeats;Communicable Diseases;Core Facility;Coughing;CRISPR screen;CRISPR/Cas technology;crosslink;Crosslinker;Data;design;Diazomethane;Disease;efficacy evaluation;Engineering;Environment;Epithelial Cells;Genes;genome-wide;Glycoconjugates;Glycoproteins;glycosylation;holotoxins;Human;in vivo;Individual;Infant;Infection;innovation;insight;Intoxication;Knock-out;Knowledge;Leukocytosis;Life;Link;Lipids;Lymphocyte;Mediating;Medical center;Metabolic;Modeling;Modernization;Molecular;Monosaccharides;N-Acetylneuraminic Acid;Nomenclature;Pathway interactions;Pertussis;Pertussis Toxin;pertussis toxin receptor;Physiological;Polysaccharides;Predisposition;Production;Proteins;receptor;Reporting;Research;Research Methodology;screening;Screening Result;Severities;Sialic Acids;Structure;sugar;Symptoms;System;Targeted Toxins;Technology;Therapeutic;Toxin;ultraviolet irradiation;United States;unvaccinated;Vaccination;Virulence Factors

PROJECT_TITLE: Discovery of pertussis toxin receptors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-H (02)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: AUSTIN

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE This application seeks support for junior researcher attendance at the 11th World Congress on Stuttering and Cluttering (formerly referred to as the “International Fluency Association Joint World Congress”), to be held May 15-19, 2024 in Austin, Texas, USA. The World Congress is a joint effort of the World Stuttering and Cluttering Organization (formerly referred to as the “International Fluency Association”), the International Stuttering Association, and the International Cluttering Association, with additional support from the Arthur M. Blank Center for Stuttering Education and Research (Austin, Texas). Support recipients will also attend two training workshops designed to optimize preparation for grant applications and publication/tenure success.

PI_NAMEs: BYRD, COURTNEY T (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: CE

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Domestic violence is a substantial public health and safety problem with lasting consequences for individuals, families, and communities. The proposed research aims to rigorously evaluate the effectiveness of implementation of domestic violence protection order firearm prohibitions in reducing subsequent firearm-related crime, injury, and death among victim-survivors, protected minors, and respondents. Findings will provide actionable information for local and state policy makers and practitioners on the design and potential impact of enacting, implementing, and enforcing these firearm prohibitions.

PI_NAMEs: ELLYSON, ALICE MARIE (contact)

PROJECT_TITLE: RFA-CE-23-006, Preventing firearm-related harm through Domestic Violence Protection Order firearm prohibitions and relinquishment


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Black youth experience persistent inequities in community violence with homicide being the leading cause of death for this population. Multilevel approaches that promote individual and collective healing processes and recognize community as an asset and agent of change are promising intervention strategies to prevent youth and community violence. We propose to use a community-based participatory research (CBPR) approach to implement and evaluate a multilevel intervention, Youth Empowered Advocating for Health (YEAH), designed to promote individual and collective healing processes to reduce risk for community violence among Black youth ages 12-17.

PI_NAMEs: WOODS-JAEGER, BRIANA  (contact)

PROJECT_TITLE: RFA-CE-23-004: Youth Participatory Action Research to Prevent Community Violence among Black youth


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: BOSTON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: PROJECT NARRATIVE The WTC-Work Study aims to identify how employment and working conditions, and union and employer policies, programs, and practices affect World Trade Center non-traditional responders' mental health, well- being, and health behaviors over the two decades since the September 11, 2001 World Trade Center terrorist attacks. Our study's findings have the potential to identify how work and workplace supports might positively contribute to workers' mental health, well-being, and health behaviors.

PI_NAMEs: PETERS, SUSAN ELIZABETH (contact)

PROJECT_TITLE: WTC-Work Study: World Trade Center Non-Traditional Responders' Employment and Mental Health


ORG_CITY: NEW YORK

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project narrative The excess cancer risk in the World Trade Center (WTC) cohorts is not solely explained by surveillance or physician bias thus excess thyroid cancer and possibly more aggressive thyroid cancer may be due to exposure to endocrine disruptors present in WTC dust. Thyroid cancer is largely unstudied in the WTC survivor population which includes adolescents and minor children even though it is well documented that childhood / adolescence exposure to endocrine disruptors is significantly associated with thyroid carcinogenesis. Identifying phenotypes and biomarkers associated with increased risk of more aggressive thyroid cancer in WTC survivors, particularly those < 18 years when exposed, will help identify patients needing more aggressive thyroid cancer screening and management, lead to more effective health care delivery for this population, and shape future studies investigating cancers with excess risk in the WTC and other environmentally exposed populations.

PI_NAMEs: VAN GERWEN, MAAIKE  (contact)

PROJECT_TITLE: The Effect of WTC Exposure on Thyroid Cancer in the Survivor Population


ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative  World Trade Center Responders report high levels of poor sleep quality and have a high prevalence of sleep disturbances known to increase risk of dementia. Particulate exposure and mental health conditions increase risk of premature cognitive impairment and neurodegeneration in WTC responders. In search of lifestyle factors to reduce risk of dementia, this project will test whether consistency of sleep at home and stability of sleep in the lab impacts emotional memory processing and blood-based markers of neurodegeneration.

PI_NAMEs: MULLINS, ANNA  (contact)

PROJECT_TITLE: Sleep stability, emotional memory and risk for neurodegeneration in World Trade Center Responders


ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: PROJECT NARRATIVE Posttraumatic stress disorder (PTSD) is very persistent and prevalent in World Trade Center (WTC) responders following the attacks of 9/11. This project build on existing DNA methylation studies to understand epigenetic contribution to PTSD risk by using a more powerful design for genome-wide DNA methylation profiling that will produce novel findings, and allow for new data to be combined with existing studies to ensure generalizability of the results. This knowledge will help to explicate pathophysiology of this disorders on molecular level, which may become targets for treatment development.

PI_NAMEs: KUAN, PEI-FEN  (contact)

PROJECT_TITLE: Methylome profile of World Trade Center related PTSD


ED_INST_TYPE: SCHOOLS OF NURSING

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative Registered nurses’ (RNs) can have trouble getting enough restful sleep due to their work hours and job stress. This project is designed to refine and test a sleep training program that can help RNs gain skills at improving sleep. With better sleep, RNs may enhance personal health and decrease safety risks to self and patients.

PI_NAMEs: HITTLE, BEVERLY M (contact)

PROGRAM_OFFICER_NAME: LIOCE, MARIA

PROJECT_TITLE: Using Cognitive-Behavioral Change and Mobile Technology to Improve RN Sleep and Fatigue

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]


ORG_DEPT: PSYCHIATRY

PHR: World Trade Center (WTC) related disorders can be ameliorated by lifestyle medicine interventions, but their efficacy is constrained by high attrition. The current project will investigate a variety of potential risk factors to develop an algorithm to forecast attrition. This may reveal pathways to attrition that can be targeted by supportive interventions, thus improving efficacy of lifestyle medicine treatments.

PI_NAMEs: KOTOV, ROMAN I (contact)

PROJECT_TITLE: Predicting Attrition from a Lifestyle Medicine Intervention


ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative World Trade Center (WTC)-exposed rescue/recovery workers who participated in the WTC Health Program (WTCHP) experience improved survival post-cancer diagnosis compared with demographically similar cancer patients from New York State. This survival benefit may be due to the level of care that these rescue/recovery workers receive as part of the WTCHP, but we cannot rule out the possibility that rescue/recovery workers were healthier than the reference population of New York State cancer patients prior to cancer diagnosis and therefore more likely to have a favorable cancer outcome (i.e., due to the healthy worker effect). The overall goal of the current proposal will address this gap in knowledge by investigating cancer survival and survival- related factors such as cancer-specific pathology and treatment initiation in WTCHP responders compared with an occupationally appropriate cohort of non-WTC-exposed responders.

PI_NAMEs: HALL, CHARLES B;WEBBER, MAYRIS P;ZEIG-OWENS, RACHEL  (contact)

PROJECT_TITLE: Cancer Survival in WTC First Responders vs. Comparable Occupational Cohorts


ORG_DEPT: MISCELLANEOUS

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Narrative We propose to employ innovative statistical and machine learning methods to assess the effects of WTC exposures and comorbidities on the full spectrum of distributions of the post-bronchodilator spirometry and oscillometry measurements, both cross-sectionally and longitudinally. Another aim of this project is to identify and evaluate vulnerable subgroups that show heterogeneous susceptibilities to WTC exposures to reduce health disparity. The findings from this study will improve our knowledge of the health effects on severe respiratory diseases related to the 9/11 terrorist attacks in the survivor population as a whole and within specific vulnerable sub-population, and will inform future risk management, clinical treatment, and address health disparities of patients in the WTC-EHC cohort.

PI_NAMEs: LIU, MENGLING  (contact);REIBMAN, JOAN

PROJECT_TITLE: Complex WTC Exposures Impacting Persistent Large and Small Airflow Limitation and Vulnerable Subgroups in the WTC Survivor Population


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE The proposed work evaluates how two firearm-related policies – Extreme Risk Protection Orders and mandatory waiting periods – affect mortality risks among handgun owners and their cohabitants. Such evaluation adds to the empirical basis regarding the extent to which actionable strategies work (and for whom they work) to reduce the rate of firearm-related deaths.

PI_NAMEs: SWANSON, SONJA ALSEMGEEST (contact)

PROJECT_TITLE: RFA-CE-23-006, Leveraging Individual-Level Data to Evaluate Policies Targeting Acute Risk Periods for Firearm Violence: Extreme Risk Protective Orders and Waiting Periods in California


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

PHR: Veterans may be afflicted by a wide range of age-related conditions that impair vision or ocular function. These include primary open angle glaucoma, cataract, and diabetic retinopathy. Our understanding of the underlying disease mechanisms for these and other conditions is incomplete, as is our appreciation for whether the disease process varies across ethnic groups. Genetic studies provide important information regarding these questions. In this project, the Million Veteran Program resources will be used to (a) identify genetic loci related to ocular conditions that are prevalent in the Veteran population; (b) compare susceptibility genes across Veteran populations of European, African or Hispanic heritage and (c) determine if susceptibility genes are shared in multiple ocular disorders, are involved in other systemic disorders, or interact with environmental factors. The information gained in this project will inform the development of new treatments for age-related eye disease.

PI_NAMEs: PEACHEY, NEAL S. (contact)

PROJECT_TERMS: admixture mapping;Adverse effects;African;African American;Age;age related;Age related macular degeneration;Algorithms;American;aqueous;biobank;Biological Markers;Blindness;Cataract;Clinical;Clinical Data;Complex;Data;Databases;Development;Diabetic Retinopathy;Diagnosis;Disease;disease phenotype;Electronic Health Record;Environmental Exposure;Environmental Risk Factor;Ethnic Origin;Ethnic Population;European;Eye;Eye diseases;eye dryness;Fuchs' Endothelial Dystrophy;Funding;Genes;Genetic;genetic analysis;genetic architecture;Genetic Identity;Genetic Predisposition to Disease;Genetic Risk;genetic risk factor;Genetic study;genetic variant;genome wide association study;genome-wide;genomic locus;Genotype;Glaucoma;Glucose;Haplotypes;Health;Heritability;Heterogeneity;Hispanic;Hispanic Americans;Informatics;Infrastructure;International Classification of Disease Codes;Investigation;Lipids;Maps;Measures;Medical;military veteran;Modeling;multi-ethnic;multiple chronic conditions;Myopia;novel;Ocular Hypertension;Outcome;Pathway interactions;Phase;phenome;Phenotype;Physiological;polygenic risk score;Population Programs;Primary Open Angle Glaucoma;Principal Component Analysis;Privatization;Process;programs;Quality Control;racial population;rare variant;Refractive Errors;Resources;Review Literature;Risk;risk sharing;Role;Sampling;sex;Smoking;Smoking Status;SNP array;Surveys;Susceptibility Gene;System;Testing;trait;United States Department of Veterans Affairs;Variant;Veterans;Veterans Health Administration;Vision;Vision Disorders;visual dysfunction;Visual impairment;Work

PROJECT_TITLE: Deciphering Genetic and Environmental Influences on Visual Disorders in the Million Veteran Program


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Infectious Diseases;Malaria;Rare Diseases;Social Determinants of Health;Vector-Borne Diseases

ORG_CITY: ITHACA

ORG_DEPT: ZOOLOGY

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE Accurately predicting transmission of mosquito-borne diseases in urban environments is challenging due to limited quantitative knowledge on the interacting effects of humidity and temperature on transmission, as well as pronounced spatial variation in human exposure to mosquitoes and mosquito relevant microclimates in cities. This proposal will utilize data generated from experiments that define key relationships between temperature, relative humidity, and transmission, along with climate data collected in the field, to build mechanistic models of temporal and spatial variation in urban malaria. Major outcomes will include an improved conceptual framework for the environmental epidemiology of urban malaria based on mosquito biology and new modeling approaches that apply this knowledge to make predictions of disease transmission.

PI_NAMEs: MURDOCK, COURTNEY  (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Affect;Africa;Anopheles Genus;Biology;Bite;Calibration;Characteristics;Cities;Climate;climate change;climate data;Coupled;Culicidae;Data;Data Set;Development;Disease;disease transmission;Environment;Environmental Epidemiology;Epidemic;epidemiological model;Epidemiology;experience;experimental study;exposed human population;Exposure to;Hot Spot;Human;Humidity;improved;Incidence;Incubated;India;innovation;Knowledge;land cover;life history;Malaria;malaria transmission;Maps;Microclimate;Modeling;Mosquito-borne infectious disease;Neighborhoods;novel;Outcome;Parasites;pathogen;Pattern;Physiology;Planets;Plasmodium falciparum;Plasmodium vivax;Population Density;predictive modeling;Process;programs;public health intervention;Readiness;Research;Research Personnel;response;Risk;Seasons;Shapes;Socioeconomic Factors;socioeconomics;surveillance data;Temperature;Testing;trait;transmission process;urban setting;Urbanization;Variant;vector;vector transmission;Vector-transmitted infectious disease;Vectorial capacity

PROJECT_TITLE: Redefining thermal suitability for urban malaria transmission in the context of humidity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(90)]


NIH_SPENDING_CATS: Bioengineering;Contraception/Reproduction;Data Science;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_NAME: INSTITUTE FOR SYSTEMS BIOLOGY

PHR: PROJECT NARRATIVE This proposal seeks to use a data-driven deep-phenotyping approach to evaluate at a systems level the mechanisms involved in placental regulation and the normal physiology of pregnancy as well as identifying how disruption of these processes is associated with common obstetric disorders. This study will enhance our knowledge of the dynamics of molecular network throughout pregnancy defining major pregnancy transition states and also generate and prioritize hypotheses of the molecular mechanisms driving some obstetric disorders, which can be used to develop future clinical interventions to promote maternal-fetal health.

PI_NAMEs: PIEKOS, SAMANTHA  (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: adverse outcome;adverse pregnancy outcome;aging process;Artificial Intelligence;Automobile Driving;Behavioral;Bioinformatics;Biological;Birth;Blood;Cessation of life;Child;Clinical;Clinical Data;cohort;Collaborations;Communities;Complex;Data;Data Commons;data integration;data platform;Data Science;Data Set;Developed Countries;Development;Developmental Biology;differential expression;Discipline of obstetrics;Disease;distributed data;Doctor of Philosophy;Early Intervention;Epidemiology;Event;Fetal Development;Fetal Growth Retardation;Fetal health;Future;Genes;Grant;Health;healthy pregnancy;Histopathology;improved;Individual;insight;Intervention;Investigation;Knowledge;knowledge graph;Learning;Life Style;Maternal and Child Health;Measurement;Mentors;metabolomics;Molecular;molecular dynamics;Multiomic Data;multiple omics;Normal Range;novel strategies;open data;open source;Outcome;Perinatal;Persons;Phenotype;phenotypic data;Physicians;Physiological;Physiological Processes;Physiology;Placenta;Placental Biology;post-doctoral training;Pre-Eclampsia;precision medicine;Pregnancy;Premature Birth;Process;Proteomics;prototype;Regulation;Research;Resources;Running;skills;Structure;Surveys;System;Systems Biology;temporal measurement;Time;Tissues;Training;transcription factor;transcription regulatory network;transcriptomics;Urine;Visualization software;wearable device;Women's Health;Work

PROJECT_TITLE: Enhancing personalized insights into common obstetric disorders using longitudinal deep-phenotyping data

STUDY_SECTION_NAME: Obstetrics and Maternal-Fetal Biology Study Section[CHHD-B]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: NEW HAVEN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Cryogenic electron-microscopy (Cryo-EM) is a new and rapidly evolving methodology for reconstructing the three-dimensional structure of proteins and biological macromolecules. The next generation of Cryo-EM problems face bottlenecks in reconstructing small molecular weight proteins, heterogeneous proteins with many conformational states, and in creating explanations for limited resolutions. This research proposes mathematical and algorithmic solutions to these problems.

PI_NAMEs: TAGARE, HEMANT D (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Address;Affect;Algorithms;Biological;Cryoelectron Microscopy;Data;detector;Face;Instruction;macromolecule;Mathematics;Methodology;Methods;Molecular Conformation;Molecular Weight;National Institute of General Medical Sciences;next generation;Noise;particle;protein structure;Proteins;reconstruction;Research;Resolution;statistics;structural biology;Structure;success;three dimensional structure;Work

PROJECT_TITLE: New Algorithms for Cryogenic Electron Microscopy

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative This program will address critical issues in cardiovascular medicine: the dwindling supply of well-trained clinical and basic researchers focused on cardiovascular disease, and the need for investigators who can thrive in the multi-disciplinary environments essential to current research approaches. Trainees must be facile with new statistical approaches to large datasets and familiar with modern Omics techniques. Our ultimate goal is to produce investigators who can not only compete successfully for extramural funding and faculty positions but who can make substantive contributions to the understanding and treatment of cardiovascular disease, which remains a major cause of morbidity and mortality in the United States.

PI_NAMEs: HO, JENNIFER E (contact);MITTLEMAN, MURRAY A

PROGRAM_OFFICER_NAME: PRICE, CANDICE

PROJECT_TITLE: Training Program in Cardiovascular Research

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative The project aims to expand the Understanding America Study to a longitudinal study of at least 20,000 individuals, including adequate representation of racial/ethnic groups to power subgroup analysis. Integrating multiple innovative data sources and technologies with the existing robust research infrastructure provides unprecedented opportunities to study the development of health and economic disparities over the life course. Resulting data will constitute a uniquely valuable resource, which will be made available to the research community without delay.

PI_NAMEs: KAPTEYN, ARIE  (contact)

PROGRAM_OFFICER_NAME: KARRAKER, AMELIA WILKES

PROJECT_TERMS: access disparities;Accounting;Address;Adult;Affect;Aging;aging population;Air;Area;Asian population;Attitude;Behavioral;behavioral response;Black Populations;California;Child Development;Cognition;cognitive testing;Collection;Communication;Communities;Complex Analysis;Consumption;COVID-19 pandemic;Custom;Data;Data Collection;data dissemination;data infrastructure;data quality;data repository;Data Sources;design;Development;Disability Insurance;Disparity;Ecological momentary assessment;economic disparity;Economics;Ecosystem;Education;Electronics;Ensure;Environment;Environmental Health;ethnic minority;Ethnic Population;Event;experimental study;Family;flexibility;Frequencies;Funding;General Population;Goals;Graph;Health;health care availability;health disparity;Healthcare;Hispanic Populations;Hour;Household;improved;Income;Individual;Inequality;Infrastructure;innovation;Institution;instrument;interest;Internet;Interview;Interviewer;Knowledge;Length;Life Cycle Stages;life history;Link;Longitudinal Studies;Machine Learning;Measures;member;Methods;Neighborhoods;new technology;next generation;novel;Outcome;Pathway interactions;Pattern;Personal Satisfaction;Personality;Persons;Physical activity;Physical environment;Plants;Policies;Pollution;Probability;programs;Questionnaires;Race;racial discrimination;racial disparity;racial minority;racial population;Recording of previous events;Records;recruit;Relaxation;Research;Research Infrastructure;Research Personnel;Resources;Respondent;response;Retirement;Sampling;Schools;Sleep;social;Social disability;Social Environment;social science research;Social Sciences;Social Security;socioeconomic disparity;Spanish/English;Subgroup;Surveys;symposium;synergism;Tablets;Technology;usability;user-friendly;wearable data;wearable device;web interface;Work

PROJECT_TITLE: A Next Generation Data Infrastructure to Understand Disparities across the Life Course

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ORG_DEPT: GENETICS

PHR: NARRATIVE Two of the most fundamental processes in biology, cell division and protein translation, have dramatically different outcomes in specialized cells. This project will investigate how animal germline cells fail to completely divide, and instead produce clusters of cells that communicate with each other through connecting bridges as they develop into eggs or sperm. We will also determine how and why genes that terminate translation normally in ovarian cells instead support efficient stop codon readthrough specifically in nerve cells of the central nervous system

PI_NAMEs: COOLEY, LYNN  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Ablation;Adult;Animals;Area;Behavioral Assay;Biological;Biological Assay;Biological Phenomena;Biology;Biotinylation;Cell Communication;Cell division;Cell membrane;Cells;Cellular biology;Central Nervous System;Cis-Acting Sequence;Cytokinesis;Cytoskeleton;daughter cell;Development;Drosophila genus;egg;Excision;Female;Genes;Genetic;Genetic Screening;Germ Cells;Germ Lines;Giant Cells;Image;intercellular communication;intercellular connection;interest;Larva;Learning;Lymphoproliferative Disorders;male;Mass Spectrum Analysis;Messenger RNA;Mitosis;Modeling;Molecular;Nerve;Neurons;Oogenesis;Open Reading Frames;ORF2 protein;Outcome;Ovarian;Ovary;Peptides;Phenotype;Process;programs;Proliferating;Proteins;Proteome;Regulation;Research;ribosome profiling;Ribosomes;sperm cell;stem;Structure;success;Terminator Codon;Testis;Tissues;Trans-Activators;Translations

PROJECT_TITLE: Noncanonical regulatory mechanisms in cell biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

PHR: PROJECT NARRATIVE Genetic neurodegenerative diseases that affect neurons, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), are excellent candidates for therapeutic CRISPR-based gene editing. This therapeutic benefit however has gone unrealized due to poor delivery of CRISPR machinery and low editing efficiency in neurons. Here, we propose two strategies to make small perturbations in neurons to increase the efficacy and specificity of CRISPR-based editing.

PI_NAMEs: MACKLIN, BRIA  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Address;Adjuvant Therapy;Affect;Alleles;Amyotrophic Lateral Sclerosis;base editing;Biological Assay;Biological Process;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;comparative;Core Facility;CRISPR therapeutics;CRISPR/Cas technology;Data;design;differentiation protocol;directed differentiation;Disease;disease phenotype;DNA;DNA Damage;DNA Repair;DNA Repair Enzymes;DNA Repair Gene;DNA Repair Pathway;DNA Sequence Alteration;DNA-Directed RNA Polymerase;Dominant-Negative Mutation;Doxycycline;Engineering;Environment;Enzymes;Event;Excision;Exhibits;Frameshift Mutation;Frequencies;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;fused in sarcoma;Future;Gene Fusion;gene repression;Gene Targeting;Genes;Genetic;Genetic Diseases;Genetic Materials;Genetic Transcription;Grant;Guide RNA;Impairment;In Vitro;in vivo;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;insertion/deletion mutation;insight;knock-down;Knock-out;Ligation;Measures;Mentorship;Messenger RNA;Methods;mutant;Mutate;Mutation;Neurodegenerative Disorders;neurogenetics;Neuronal Differentiation;Neurons;next generation sequencing;Nonhomologous DNA End Joining;Nonsense-Mediated Decay;novel virus;Outcome;overexpression;Pathologic;Pathway interactions;pharmacologic;Phenotype;postmitotic;Prevalence;Probability;Process;Proteins;Proteomics;Protocols documentation;Regulation;repaired;Research;RNA;Role;Small Interfering RNA;small molecule inhibitor;Specificity;synergism;System;targeted treatment;Therapeutic;therapeutic candidate;therapeutic genome editing;Time;Tissues;Training;transcription factor;transcriptomics;Transgenic Organisms;Virus-like particle;Work

PROJECT_TITLE: Cellular perturbations to enhance precise therapeutic genome editing to treat FTD/ALS


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Prevention

ORG_CITY: CHAMPAIGN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: This project aims to identify and validate new carcinogenesis-dependent pathognomonic nanoscale chromatin structures in intestinal tumorigenesis, which can be extended to can potentially be extended to other cancers. The success of this project can advance our understanding of disrupted chromatin folding in early carcinogenesis and ultimately be used for improving cancer risk stratification and facilitating the development and evaluation of new preventive strategies.

PI_NAMEs: LIU, YANG  (contact)

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Adenocarcinoma;adenoma;Affect;Archives;Biological;biological research;cancer diagnosis;cancer risk;carcinogenesis;Cells;Characteristics;ChIP-seq;Chromatin;Chromatin Structure;Cleavage Under Targets and Release Using Nuclease;Clinical;Clinical Management;clinically significant;Colonoscopy;Colorectal;Colorectal Adenoma;Colorectal Cancer;Colorectal Neoplasms;Computer software;Data;Development;Distal;DNA biosynthesis;DNA Damage;Early Diagnosis;Evaluation;Event;Fluorescence;Fluorescence Microscopy;Formalin;Gene Expression Profile;Genes;Genome;high risk;high throughput analysis;Image;Image Analysis;imaging system;improved;Indolent;innovation;intestinal tumorigenesis;Intestines;Lesion;light microscopy;Location;Maintenance;Malignant - descriptor;Malignant Neoplasms;Microscopy;Molecular;molecular imaging;Molecular Profiling;mouse model;nanoscale;Nanoscopy;neoplastic cell;Nobel Prize;Normal tissue morphology;novel;Ontology;Optics;Outcome;Paraffin Embedding;Pathology;Pathway interactions;Patient Care;Patients;premalignant;Preparation;Prevention strategy;Preventive;Protocols documentation;reconstruction;Recurrence;Reproducibility;research clinical testing;Resolution;Risk;risk prediction;risk stratification;Sampling;screening;Structural defect;success;superresolution imaging;superresolution microscopy;System;Techniques;Tissue Embedding;Tissue Sample;transcriptome sequencing;tumor;tumor growth;ultra high resolution

PROJECT_TITLE: Imaging nanoscale chromatin folding in early carcinogenesis

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Project Narrative  A joint model of longitudinal and multistate models is proposed to investigate the relationship between the risk of autoantibody development and subsequent type 1 diabetes risk, and the longitudinal pattern of risk factors. Based on the joint model, we will develop a dynamic prediction algorithm that can predict type 1 diabetes risk given the status of autoantibodies and the historical data from an individual. This project can facilitate the early identiﬁcation of individuals at high risk of type 1 diabetes.

PI_NAMEs: YOU, LU  (contact)

PROGRAM_OFFICER_NAME: AKOLKAR, BEENA

PROJECT_TERMS: Algorithms;Autoantibodies;Birth;Characteristics;Child;chronic autoimmune disease;Clinical;Cohort Studies;Complex;complex data;Complications of Diabetes Mellitus;Cost of Illness;Data;Data Set;Development;Diabetes autoantibodies;Diabetes Mellitus;diabetes risk;Diagnosis;Diagnostic;Disease;Disease Progression;disorder risk;Early identification;Event;flexibility;Future;Genetic Predisposition to Disease;Genetic Risk;Goals;hazard;health management;High Performance Computing;high risk;Immunologics;improved;Individual;Infrastructure;Injections;Insulin;Insulin deficiency;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;islet cell antibody;Joints;Measurement;Measures;Metabolic;Methodology;Methods;Modeling;Monitor;Natural History;novel diagnostics;Patients;Pattern;Performance;personalized predictions;Physicians;prediction algorithm;predictive modeling;prevent;Probability;Recording of previous events;Research;Risk;Risk Factors;risk stratification;ROC Curve;semiparametric;Specificity;Statistical Methods;Statistical Models;Structure;Structure of beta Cell of islet;Technology;Time;time use;Update

PROJECT_TITLE: Dynamic prediction of type 1 diabetes risk and autoantibody status by a joint model of longitudinal and multistate models


NIH_SPENDING_CATS: Lung;Pulmonary Hypertension

ORG_CITY: BALTIMORE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative Pulmonary hypertension is a serious disease of high blood pressure in the blood vessels of the lungs that often leads to heart failure and death. This proposal investigates a novel pathway of inflammation that might cause this disease and hopes to define several new potential pathways for treatment.

PI_NAMEs: JOHNS, ROGER A (contact);LIN, QING

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: adaptive immune response;adaptive immunity;Address;Agammaglobulinaemia tyrosine kinase;Automobile Driving;B-Cell Activation;B-Cell Antigen Receptor;B-Lymphocytes;Binding;Blood Vessels;Bone Marrow;CASP1 gene;cell injury;Cells;Cessation of life;chemokine;Chemotaxis;Chronic;Clinical;cytokine;Data;Development;diagnostic biomarker;Disease;Exposure to;Goals;Heart;Heart failure;hemodynamics;HMGB1 gene;Homologous Gene;Human;Hypertension;Hypoxia;hypoxia-induced pulmonary hypertension;IL18 gene;Immune response;Immunotherapeutic agent;In Vitro;in vivo;Inflammasome;Inflammation;Inflammatory;Inflammatory Infiltrate;Inflammatory Response;Innate Immune Response;Interleukin-1 beta;Investigation;Lung;Macrophage;Mediating;Mediator;migration;Modeling;Modification;Molecular;mortality;Mus;Myeloid Cells;novel;Pathologic;Pathway interactions;Patients;Pattern;Phenotype;Phosphorylation;polymerization;Polymers;Process;Production;Proliferating;Proteins;Pulmonary Hypertension;pulmonary vascular cells;pulmonary vascular remodeling;Receptor Signaling;Recombinants;Reporting;resistin;response to injury;Rodent;Rodent Model;Role;Scleroderma;Serum;Severities;Severity of illness;Signal Transduction;Smooth Muscle Myocytes;Structure of parenchyma of lung;Time;Tyrosine;vascular inflammation;Vascular remodeling;Vascular Smooth Muscle;Work

PROJECT_TITLE: Resistin regulates NLRP3 inflammasome in pulmonary hypertension

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF MISSOURI KANSAS CITY

ORG_STATE: MO

PHR: Project Narrative  While it has been over 20 years since the Institute of Medicine called for more evidence-based, patient- centered care, cardiovascular care is still highly variable and fails to achieve its full potential. The UMKC T32 in Cardiovascular Outcomes Research trains diverse, talented post-doctoral scholars committed to improving the quality and value of healthcare though knowledge generation, implementation and evaluation of healthcare innovations.

PI_NAMEs: SPERTUS, JOHN A (contact)

PROGRAM_OFFICER_NAME: SIDDIQUI, AYESHA SAEED

PROJECT_TERMS: Cardiovascular system;Outcomes Research;Training Programs

PROJECT_TITLE: CARDIOVASCULAR OUTCOMES RESEARCH TRAINING PROGRAM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Many anesthetics work by binding to proteins embedded in the lipid membranes that encase cells. Current methods for computationally predicting exactly where on the protein such drugs bind are inefficient or inaccurate, because it is challenging to properly consider the effect of the complex membrane environment. This project seeks to improve the widely used and efficient molecular docking method to more accurately consider the membrane, and therefore improve our ability to predict these binding sites.

PI_NAMEs: JOSEPH, THOMAS THENGANPALLIL (contact)

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TERMS: Address;Affinity;Anesthesia procedures;Anesthetics;Binding;Binding Sites;Calibration;Cardiovascular system;career;Cells;clinical application;Complex;Computers;Computing Methodologies;Data;design;detection method;Development;Docking;Environment;Evaluation;Floods;Free Energy;Future;General anesthetic drugs;Goals;Grain;Hydrophobicity;improved;Integral Membrane Protein;interest;Ion Channel;Ligand Binding;Ligands;Lipid Bilayers;Lipids;lipophilicity;Membrane;Membrane Lipids;Membrane Proteins;Mental Depression;Methodology;Methods;Modernization;Molecular;Molecular Conformation;molecular dynamics;Neurologic;Pharmaceutical Preparations;Physicians;Physiological;Polynomial Models;Postoperative Nausea and Vomiting;Proteins;receptor;Rotation;Scientist;side effect;Site;supercomputer;theories;Transmembrane Domain;Water;Work

PROJECT_TITLE: Efficient prediction of transmembrane binding sites for anesthetic ligands


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative Antibiotic stewardship programs optimize the use of antibiotics to improve clinical outcomes, decrease adverse drug events, and reduce the emergence of antibiotic resistant bacteria, but typically neglect prescribing at the transition from hospital discharge to home. We will utilize an implementation science framework to develop, implement, and test the effectiveness of a multifaceted discharge stewardship intervention for hospitalized children with pneumonia, urinary tract infections, or skin/soft tissue infections across four hospitals. This will establish a foundation for future expansion of discharge stewardship to additional target populations.

PI_NAMEs: GERBER, JEFFREY STEPHEN (contact)

PROGRAM_OFFICER_NAME: MILLER, MELISSA

PROJECT_TITLE: Implementing a Discharge Stewardship Bundle to improve antibiotic use at transition from hospital to home

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: Project Narrative The inability for children to receive definitive general pediatric inpatient care within rural communities creates significant inequities in quality and access to care. Addressing these inequities for children in setting of scarce resources and limited infrastructure requires health policy change and innovative initiatives specifically designed for the rural community. This proposal aims to establish system-level (e.g., provider, hospital, community) facilitators for the provision of general pediatric inpatient care in rural hospitals.

PI_NAMEs: MCDANIEL, CORRIE ERIN (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Provision of Definitive Care for Children in Rural Hospitals

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: This Collaborative Merit Award application (CMA) is a synergistic, multidisciplinary project focused on the mechanistic understanding of platinum resistance as the foremost cause of death in ovarian cancer patients. The overall strategy is to integrate ideas, resources, and expertise in advanced technologies to identify novel therapeutic targets and biomarker-driven treatments for ovarian cancer patients. CMA3 is focused to investigate the reprogramming of recurrent HGSOC cells to a more aggressive and therapy resistant tumor subpopulation with neuroendocrine (NE)-like features. Studies in this project will define the characteristics and molecular pathways activated in NE-like cells while simultaneously exploring unique vulnerabilities that can be exploited therapeutically with drugs poised to target NE-like cells. Aims of this proposal using human ovarian cancer samples and innovative precision medicine approaches have the potential for immediate translation into future clinical trials.

PI_NAMEs: MEMARZADEH, SANAZ  (contact)

PROJECT_TERMS: Address;Award;Bioinformatics;Biological Assay;Biological Availability;Biological Markers;Biological Models;biomarker driven;cancer cell;Cancer cell line;Cancer Patient;Carboplatin;Carcinoma;Caring;Cause of Death;Cell Death;Cells;Cellular biology;Cessation of life;Characteristics;Chemoresistance;chemotherapy;Cholesterol;cholesterol biosynthesis;Clinical;Clinical Management;Clinical Trials;Clinical Trials Design;clinically relevant;Coculture Techniques;Data;Data Set;Databases;Dependence;Designer Drugs;Development;Diagnosis;Disease;Disease Resistance;DNA Repair Pathway;Dose;Drug Addiction;drug candidate;Drug Screening;drug sensitivity;Drug Targeting;drug testing;druggable target;efficacy testing;Fatal Outcome;fatty acid oxidation;Future;Gene Expression Profile;Genes;Genetic;Goals;Harvest;Histologic;Human;Immunocompetent;improved;In Vitro;in vivo;in vivo evaluation;inhibitor;innovation;intraperitoneal;kinase inhibitor;Knowledge;Link;Lipids;Malignant Epithelial Cell;Malignant neoplasm of ovary;Malignant Neoplasms;Membrane Lipids;Membrane Transport Proteins;Metabolic;metabolic abnormality assessment;metabolic imaging;metabolic profile;Metabolism;Modeling;Molecular;mouse model;multidisciplinary;Mus;neoplastic cell;neuroendocrine phenotype;Neuroendocrine Therapy;Neurosecretory Systems;new therapeutic target;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Oncogenic;Organoids;Ovarian;ovarian neoplasm;Ovarian Serous Adenocarcinoma;oxidized lipid;Pathology;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiological;Platinum;PLK1 gene;Population;pre-clinical;precision medicine;Predisposition;pressure;prevent;Proteome;Proteomics;Publishing;Recurrence;Recurrent disease;refractory cancer;Research Personnel;Resistance;resistance mechanism;Resource Sharing;Resources;Robotics;Role;Sampling;Serous;spectroscopic imaging;standard care;Systems Biology;targeted agent;targeted treatment;Technology;Testing;Therapeutic;therapeutic biomarker;therapy resistant;transcriptome;transcriptome sequencing;transcriptomic profiling;transcriptomics;translational potential;Translations;Treatment Efficacy;treatment strategy;tumor;Tumor Debulking;tumor microenvironment;tumor progression;TXN gene;Woman;women's diagnosis;Work

PROJECT_TITLE: BCCMA: Overcoming chemoresistance in ovarian cancer: Targeting Unique Vulnerabilities in Neuroendocrine-like Ovarian Cancer Cells


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Heart Disease;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: SPRINGFIELD

ORG_NAME: BAYSTATE MEDICAL CENTER, INC.

PHR: PROJECT NARRATIVE Regular physical activity is essential for healthy aging of the heart and for older adults with heart disease, participation in cardiac rehabilitation is an ideal opportunity to deliver a highly tailored and personalized exercise prescription. In this project, we will evaluate the impact of a tailored exercise prescription that optimizes exercise intensity in cardiac rehabilitation, compared to usual care, with the goal to maximize fitness gains and long-term physical activity. We anticipate our results will help improve exercise prescription tailoring to help older adults increase their fitness, improve their levels of physical activity, and enjoy both a better quality and quantity of life as they age.

PI_NAMEs: PACK, QUINN RUSSELL (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: Accelerometer;acceptability and feasibility;Acute;Address;Age;Aging;Anxiety;Benchmarking;Cardiac;cardiac aging;Cardiac health;Cardiac rehabilitation;Cardiology;Cessation of life;Clinical;Counseling;Coupled;Data;economic outcome;Effectiveness;effectiveness outcome;efficacy evaluation;efficacy testing;Elderly;Event;evidence base;Exercise;exercise adherence;exercise intensity;Exercise Physiology;exercise prescription;Exercise Test;exercise training;Exertion;experience;Expert Opinion;Face;Failure;Female;fitness;Fright;Geriatrics;Goals;Guidelines;healthy aging;Heart Diseases;Heart Rate;Hospitalization;implementation outcomes;improved;improved outcome;indexing;individual patient;individual response;Ischemia;Knowledge;Life;Life Style;loss of function;Measures;Mediating;Metabolic;Methods;mortality;multidisciplinary;Myocardial Infarction;older adult;Operative Surgical Procedures;Outcome;Outpatients;patient response;Patients;Perception;Persons;Pharmaceutical Preparations;Physical activity;Physical Function;Physical Performance;Physicians;pilot trial;Positioning Attribute;Prevention program;Procedures;Prognosis;programs;psychologic;Psychological Factors;psychological outcomes;Psychology;Quality of life;randomized trial;Randomized, Controlled Trials;Recommendation;Recovery;recruit;Rehabilitation Centers;response;Rest;Role;Scientist;secondary outcome;Secondary Prevention;Self Efficacy;sex;SF-36;Strenuous Exercise;Stress Tests;Stroke;Techniques;Testing;Time;Training;treatment as usual;trial comparing;United States;Walking;Workload

PROJECT_TITLE: Improving outcomes from cardiac rehabilitation among older adults through exercise testing and individualized exercise intensity prescriptions

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Type 2 myocardial infarction (MI) is a common subtype of MI, experienced by over 280,000 individuals in the United States each year, and is characterized by myocardial necrosis occurring due to a mismatch in myocardial oxygen supply/demand. This current project aims to determine whether differences exist in the health status of persons with type 2 MI compared to type 1 MI, to explore clinician and patient perspectives on the use of cardiac rehabilitation for type 2 MI, and to assess if a multifaceted intervention can increase attendance at cardiac rehabilitation and potentially improves the health status of persons with type 2 MI. Cardiac rehabilitation has the potential to be the first therapy to improve the health status of this high-risk population who experience a type 2 MI.

PI_NAMEs: MCCARTHY, CIAN PATRICK (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Acute myocardial infarction;adjudication;Adoption;Affect;Appointment;Award;Benefits and Risks;cancer type;Cardiac rehabilitation;Cardiovascular system;career;Characteristics;Clinical;clinical trial implementation;Clinical Trials;Clinical Trials Design;cohort;comorbidity;coronary plaque;Data;design;Diagnosis;Dimensions;effectiveness/implementation hybrid;effectiveness/implementation trial;Electronic Mail;Enrollment;EuroQOL;Event;Evidence based treatment;Exercise;experience;Foundations;frailty;Frequencies;Goals;Guidelines;Health;health difference;Health Status;Health system;Heart failure;high risk population;implementation science;implementation/effectiveness;improved;improved outcome;Individual;Intervention;Investigation;Knowledge;Leadership;Learning;Measures;Mental Depression;Mentors;Mentorship;mortality;multi-component intervention;Myocardial;Myocardial Infarction;myocardial injury;Myocardial Ischemia;Necrosis;New England;Outcome;Outcome Measure;Oxygen;patient engagement;Patient Outcomes Assessments;Patients;Pattern;Perception;Persons;Physical Function;Physical Performance;Physicians;Physiological;Positioning Attribute;Prevalence;Prognosis;programs;prospective;Published Comment;Quality of life;Questionnaires;Randomized;randomized, clinical trials;Recommendation;Recurrence;Reporting;Research;Research Design;Research Personnel;Research Proposals;research study;Risk;Role;Rupture;Safety;smartphone application;Stress;Surveys;Testing;Training;Translating;treatment as usual;treatment strategy;United States;United States National Institutes of Health;virtual;Writing

PROJECT_TITLE: Improving the Health Status of Individuals with Type 2 Myocardial Infarction

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Eye Disease and Disorders of Vision;Wound Healing and Care

ORG_CITY: COLUMBIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: Narrative Carbofuran (a pesticide) and chlorine (a bleaching and warfare agent) exposure to humans show high ocular morbidity. This project tests a novel hypothesis that mTORC1-mediated dysfunctional autophagosome formation and lysosomal biogenesis are a dominant operating mechanism for corneal damage from exposure of carbofuran or chlorine. This project profiles clinical symptoms and defines underlying mechanism mediating corneal injury after carbofuran (aim-1) and chlorine (aim-2) exposure using two animal species and donor human corneas.

PI_NAMEs: GUPTA, SUNEEL ;MOHAN, RAJIV RAVINDRA (contact);TRIPATHI, RATNAKAR

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Acute;Agriculture;Anatomy;Animals;Autophagocytosis;Autophagosome;Biogenesis;Blindness;Cadaver;Carbamates;Chemical Exposure;chemical threat;Chemicals;Chlorine;Chronic;Clinical;clinical diagnostics;Cornea;corneal epithelium;Corneal Injury;Data;Defect;density;Diagnostic Imaging;Disinfectants;Endothelial Cells;Euthanasia;Event;experience;Exposure to;Eye;Fluorescein;Genes;genetic signature;Goals;Health;Histologic;Homeostasis;Human;In Vitro;in vivo;Keratoconus;Knowledge;Link;Maintenance;Mediating;Methods;Microscope;microscopic imaging;Microscopy;Modeling;Molecular;Molecular Target;Morbidity - disease rate;multimodality;Mus;New Zealand;novel;novel strategies;ophthalmic examination;Optical Coherence Tomography;Organ Culture Techniques;Oryctolagus cuniculus;Patients;Periodicals;Persons;Pesticides;Phenotype;Pilot Projects;Play;prevent;Primary Cell Cultures;programs;Public Health;Publications;Publishing;Records;Reporting;Rodent Model;Role;Symptoms;System;Techniques;Testing;Thinness;Time;tomography;tonometry;tool;Toxic effect;Transmission Electron Microscopy;United States National Institutes of Health

PROJECT_TITLE: Late/chronic corneal injury following threat chemical exposure


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE Severe maternal morbidity (SMM) is a significant public health problem in the United States (U.S.), especially among Black birthing people, a population at highest risk of poor birth outcomes. This study will use quantitative and qualitative methods to describe Black birthing people's experiences with chronic racial discrimination (day- to-day occurrences of interpersonal racial discrimination occurring outside the medical setting) and acute racial discrimination in medical settings (discrimination experienced inside the medical setting, perpetuated by nurses, midwives, and obstetricians) and disrespectful care, and explore how these experiences impact SMM outcomes. The findings of this study have the potential to impact practice in many ways, including revision of standardized care practices of providers to improve risks of adverse outcomes in minority populations.

PI_NAMEs: JEAN LOUIS, ROSELINE  (contact)

PROGRAM_OFFICER_NAME: TYUS, NADRA

PROJECT_TERMS: Acute;adverse maternal outcomes;adverse outcome;anesthesia complication;antenatal;Birth;Black race;Blood Transfusion;Caring;case control;Case/Control Studies;Childbirth;Chronic;Clinical;Communities;Country;Data;Dehumanization;Demographic Survey;design;dietary adherence;Discrimination;Disseminated Intravascular Coagulation;Eclampsia;Enrollment;experience;Facebook;Health;Health behavior;health inequalities;Health Personnel;Healthcare Systems;high risk;Hospitalization;improved;indexing;individual patient;Instagram;Interview;intrapartum;Maternal and Child Health;Measures;Medical;medication compliance;Methods;Midwife;Minority;Minority Groups;minority patient;Mothers;Myocardial Infarction;Nurses;Outcome;outcome disparities;Participant;Patients;perceived discrimination;Perinatal;Persons;physical abuse;Physicians;Population;postpartum care;Postpartum Period;Pregnancy;Pregnancy Outcome;Prenatal care;programs;Provider;Public Health;Publishing;Qualitative Methods;Race;racial discrimination;racial disparity;racial minority population;racism;recruit;Registered nurse;Reporting;Research;research study;Resources;Risk;Sampling;Sepsis;severe maternal morbidity;Sexual abuse;social stigma;standardized care;State Hospitals;Surveys;Time;United States;USAID;Verbally abusive behavior;World Health Organization

PROJECT_TITLE: The Impacts of Racial Discrimination and Disrespectful Maternity Care on Severe Maternal Morbidity Among Black Birthing People in The United States

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(83)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Dietary Supplements;Heart Disease;Hypertension;Nutrition;Prevention

PHR: PROJECT NARRATIVE / RATIONALE Following a healthy dietary pattern reduces blood pressure and risk for cardiovascular disease. This proposed research will discover, replicate, and validate biomarkers of a healthy dietary pattern and elucidate metabolic pathways underlying the association between a healthy dietary pattern and blood pressure.

PI_NAMEs: REBHOLZ, CASEY MARIE (contact)

PROGRAM_OFFICER_NAME: BROWN, ALISON GWENDOLYN MARY

PROJECT_TERMS: Address;Adherence;Adult;Amines;Atherosclerosis Risk in Communities;Betaine;Biological;Biological Assay;Biological Markers;Biological Process;Biomarker of Dietary Intake;biomarker panel;biomarker selection;biomarker validation;Biometry;Blood;Blood Pressure;blood pressure reduction;candidate identification;candidate marker;candidate validation;Cardiac health;Cardiometabolic Disease;cardioprotection;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;Cholesterol;Chronic Disease;Citrus;Clinical;Coffee;cohort;Cohort Studies;Collaborations;Communities;Consumption;cost effective;Dairy Products;DASH diet;Data;Diet;dietary;dietary adherence;Dietary Assessment;dietary control;Dietary Fiber;Dietary intake;Dietary Intervention;Dietary Practices;direct application;Disease Outcome;Ensure;Fatty acid glycerol esters;feeding;Fibrinogen;follow-up;Food;Fruit;Funding;Goals;Hypertension;hypertension prevention;improved;insight;Intake;Intervention Trial;Knowledge;Laboratories;Measurement;Measures;Mediating;member;men;Metabolic Pathway;metabolome;metabolomics;Methodology;Methods;middle age;modifiable risk;multiple omics;novel marker;Nutrient;nutrition;Nutritional Biochemistry;Outcome;Oxides;Pathway interactions;Phase;Physiological;Population Heterogeneity;Prevention approach;Principal Investigator;Processed Meats;Proline;Proteins;Proteome;Proteomics;Public Health;Publishing;Randomized;Recording of previous events;repository;Research;Research Design;Research Personnel;Risk;Risk Reduction;saturated fat;Sodium;Specimen;study population;Techniques;Training;United States National Institutes of Health;Urine;Validation;Vegetables;Woman;Xanthines

PROJECT_TITLE: Discovery, Replication, and Validation of Biomarkers of the DASH Diet and Hypertension

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Skin Cancer

ORG_DEPT: BIOLOGY

PHR: NARRATIVE Extracellular signal-regulated kinases ERK1 and ERK2 are prototypes of the widely conserved mitogen-activated protein kinases (MAP Ks), and their aberrant activation drives tumorigenesis and confers therapeutic resistance. This proposal will investigate a previously unrecognized post-translational modification that may be critical for the specific and efficient activation of ERK. The insights generated from this work will shed important light on the fundamental issues pertaining to mitogenic signaling in normal and malignant cells, and will likely aid the development of effective therapies for a wide range of tumors characterized by hyperactive ERK.

PI_NAMEs: YANG, XIAOLU  (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Amino Acid Motifs;anti-cancer research;base;Biochemical;Biology;BRAF gene;cancer cell;cancer therapy;cell behavior;Cell Line;Cells;Deubiquitinating Enzyme;Development;Drug resistance;Drug Targeting;effective therapy;Etiology;Eukaryota;extracellular;Extracellular Signal Regulated Kinases;FDA approved;Goals;Guanosine Triphosphate Phosphohydrolases;Human;Hyperactivity;inhibitor;insight;Knowledge;Link;Malignant Neoplasms;Mammalian Cell;MAP Kinase Kinase Kinase;MAP3K1 gene;MAPK1 gene;MAPK3 gene;MEKs;Melanoma;Melanoma Cell;Metastatic Melanoma;Mitogen-Activated Protein Kinase Kinases;Mitogen-Activated Protein Kinases;Modeling;Modification;Molecular;Mutation;Normal Cell;novel;Oncogenic;overexpression;Pathogenesis;Pathologic Processes;Pathway interactions;patient derived xenograft model;Patients;Phosphorylation;Phosphotransferases;Physiological Processes;Polyubiquitin;Polyubiquitination;Post-Translational Protein Processing;Prevalence;protein function;Proteins;prototype;Receptor Protein-Tyrosine Kinases;Regulation;Resistance;resistance mechanism;response;Role;Sampling;Signal Pathway;Signal Transduction;Site;Specific qualifier value;Specificity;Stimulus;Testing;therapy resistant;transmission process;TRIM Motif;tumor;Tumor Suppressor Proteins;tumorigenesis;ubiquitin isopeptidase;ubiquitin ligase;Ubiquitination;Unresectable;upstream kinase;virtual;Work;Xenograft procedure

PROJECT_TITLE: Regulation of the ERK signaling pathway by K63-linked polyubiquitination

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Eye Disease and Disorders of Vision;Genetics;Mental Health;Neurosciences;Social Determinants of Health

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

PHR: Project Narrative Cadmium is a near ubiquitous food contaminant that the general (non-occupational, non-smoking) population ingests at higher levels than the WHO determined provisional tolerable weekly intake. Cadmium is associated with impaired vision, learning challenges and behavioral disorders, with possible cascading effects on future generations. This proposal examines how cadmium exposure insults vision and genetic profiles leading to negative effects on learning, memory, and behavior in juveniles and across generations using zebrafish (Danio rerio) as a model, which supports NIEHS new initiative on Environmental Risks for Psychiatric Disorders.

PI_NAMEs: SHELTON, DELIA S (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Ablation;Achievement;Adolescent;Adverse effects;Advisory Committees;Affect;age related;Animals;antisocial behavior;Architecture;Area;Behavior;Behavior Disorders;Behavioral;Behavioral Assay;behavioral impairment;Behavioral Paradigm;Bioinformatics;bioinformatics tool;Biological;Biological Assay;Biological Markers;Brain;burden of illness;Cadmium;career;Cells;Central Nervous System;Cessation of life;Chemicals;Chronic;Cognitive;Complement;cost;Data;Defect;design;Development;dietary;Dietary Cadmium;disability;Disease;Disruptive Behavior Disorder;Early Intervention;Ecology;Electrophysiology (science);Environment;Environmental Exposure;Environmental Risk Factor;environmental stressor;Epidemiology;Epigenetic Process;Etiology;Exposure to;Food;Future Generations;Gene Expression;Gene Expression Profiling;Generations;Genetic;Goals;Half-Life;Health;Heavy Metals;high throughput screening;Human;imaging modality;Immunohistochemistry;Impairment;improved;in vivo;Inductively Coupled Plasma Mass Spectrometry;Ingestion;insight;Instruction;Intake;intergenerational;Intervention;Investigation;Knowledge;laser capture microdissection;Lasers;late life;Learning;Learning Disabilities;Life;Link;Memory;Mental disorders;Mentors;Methods;Modeling;Modernization;Molecular;Molecular Toxicology;National Institute of Environmental Health Sciences;Nervous System Physiology;neural;neurocognitive disorder;neuropathology;neurophysiology;Neuropsychology;Neurosciences;neurotoxicity;non-smoking;novel;Ocular Physiology;Outcome;Pathology;Pathway interactions;Perception;Phase;Physiological;Policies;pollutant;Pollution;Population;Positioning Attribute;premature;Prevention;Public Health;Research;Research Design;Research Personnel;Resources;response;Retina;Rodent;Role;screening;Sensory;sensory mechanism;skills;social;Social Behavior;Social Development;social influence;superior colliculus Corpora quadrigemina;symposium;System;Systems Biology;Techniques;Technology;Testing;Tissues;Toxic effect;Toxicology;Training;transcriptome sequencing;Transgenic Organisms;Vision;Visual;Visual impairment;visual motor;Visual System;Water;Work;Zebrafish

PROJECT_TITLE: Sensory Mechanisms of Cadmium-Induced Behavioral Disorders Across Generations


NIH_SPENDING_CATS: Bioengineering;Congenital Structural Anomalies;Genetics;Human Genome;Kidney Disease;Pediatric;Urologic Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative The GenitoUrinary Development Molecular Anatomy Project (GUDMAP) has been instrumental to research on urogenital development and diseases. Our proposed work will greatly enhance the current GUDMAP database by targeting structures and organs that have not been covered, as well as by extending into building spatially resolved high complexity molecular atlases. Our application of single cell omics, spatial transcriptomics, multiplex imaging, light sheet microscopy, and advanced computational multi-dimensional atlas building will also help to elevate GUDMAP to a higher level with unprecedented coverage and resolution.

PI_NAMEs: CHEN, FENG  (contact);DING, LI

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: 3-Dimensional;Ablation;Age;analysis pipeline;Anatomy;Atlases;biological systems;Body System;Cell Nucleus;Cells;Cellular Structures;Childhood;Chromosome Mapping;Communities;Computer Analysis;congenital anomalies of the kidney;Data;Databases;Development;Dimensions;Disease;disease model;Epigenetic Process;epigenetic profiling;experience;experimental study;Fertilization;Gene Expression;Gene Silencing;Genes;Genitourinary system;Human;Imaging technology;Infrastructure;Institution;Kidney;Light;Lower urinary tract;Lymphatic;male;Maps;Mesenchyme;microscopic imaging;Microscopy;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;multiple omics;multiplexed imaging;Mus;Nerve;new technology;Organ;Organ Model;Penetration;Phenotype;Population;prenatal;Procedures;Process;Prostate;Recurrence;Reproducibility;reproductive organ;Research;Research Personnel;Resolution;Signal Transduction;single nucleus RNA-sequencing;stem cell population;Structure;System;Technology;Time;transcriptome;transcriptomic profiling;transcriptomics;tumor;Ureter;Ureteropelvic junction obstruction;Urinary tract;Work

PROJECT_TITLE: Creating high-resolution multi-omics molecular atlases for developing urogenital organs


NIH_SPENDING_CATS: Hypertension;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative The secondary active cation-chloride cotransporters (CCCs) play fundamental roles in salt handling by the kidneys and inhibitory synaptic transmission in the nervous system. In this proposal, we will combine structural, biochemical, functional, and pharmacological approaches to elucidate how CCCs orchestrate concerted conformational changes to shuttle ions across membrane, how they interact with anti-hypertensive inhibitory diuretics, and how they are regulated by cognate kinases and phosphatases in response to hormones and cell volume perturbation. Successful outcomes will facilitate the development of novel therapeutic strategies for the treatment of hypertension, edema, and various brain disorders and psychiatric conditions.

PI_NAMEs: CAO, ERHU  (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: absorption;Acceleration;Affect;Agonist;Aminobutyric Acids;anti-epileptic agents;Anti-Hypertensive Agents;Architecture;Binding;Biochemical;Biological Assay;biophysical analysis;Blood Pressure;Brain Diseases;Cations;Cell Volumes;Cells;Chlorides;Clinical;Complex;Cryoelectron Microscopy;Development;dimer;Disease;Diuretics;Drosophila genus;drug development;Drug Interactions;Edema;Educational process of instructing;Electrolyte Balance;Epilepsy;Epithelium;Equilibrium;falls;Family;Family member;Fluorescence;Foundations;Goals;high throughput screening;Homeostasis;Hormones;Human;human disease;Hypertension;hypertension treatment;hypertensive;Hypotensives;improved;inhibitor;innovation;Ion Channel Gating;Ion Cotransport;Ion Transport;Ions;Kidney;Lead;Learning;Ligands;Liposomes;Membrane;Modeling;Molecular;Molecular Conformation;Molecular Target;Movement;Mus;Mutation;Nervous System;neuronal excitability;Neurons;Neurotransmitters;novel;novel therapeutic intervention;Outcome;Paralysed;particle;Pathway interactions;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphorylation Inhibition;Phosphotransferases;Physiological;Play;pre-clinical;protein structure;Proteins;reconstitution;Recovery;recruit;Regulation;Resolution;response;Role;Seizures;Series;small molecule;Sodium Chloride;Specificity;Spinal cord injury;Structure;success;symporter;synaptic inhibition;Synaptic Transmission;Syndrome;Testing;Therapeutic;Thiazide Diuretics;tool;trafficking;ubiquitin-protein ligase;Urine;Visualization;wasting

PROJECT_TITLE: Structures and Pharmacology of Cation-Chloride Cotransporters

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: Pharmacological therapies for spinal cord injury (SCI), such as methylprednisolone, have limited efficacy. However, a potential alternative treatment, low-dose estrogen (E2), has been found to be neuroprotective in SCI. Thus, studies in this application are focused on investigating the effects of novel fast and slow release E2-loaded nanoparticles (NP) on neuronal dysfunction and skeletal muscle loss in a rat contusion model of severe SCI. Protection of neural function in SCI following treatment with a combination of fast-release (FNP-E2) and slow-release (SNP-E2) formulations can help preserve and stabilize muscle fibers, which are intricately involved in recovery of function, leading to improved locomotor rehabilitation in combat veterans with severe SCI.

PI_NAMEs: BANIK, NAREN L (contact)

PROJECT_TERMS: Acute;alternative treatment;Anti-Inflammatory Agents;Area;Astrocytes;Attenuated;Axon;axon injury;Biodistribution;Bioenergetics;Bladder;Cells;chemokine;Cicatrix;Clinical;Clinical Trials;combat veteran;Combined Modality Therapy;comparative;Complex;Contusions;Correlative Study;cytokine;Data;Denervation;Diabetes Mellitus;Dose;Drug Delivery Systems;effective therapy;Epithelium;estrogenic;Estrogens;experience;F-Box Proteins;Fibroblasts;Formulation;functional outcomes;Gel;General Population;Gliosis;Goals;Health;High Prevalence;Hormonal;Human;Immobilization;Impairment;improved;In Vitro;in vivo;Individual;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;Injury;insight;Insulin Resistance;Intervention;Kinetics;Laboratories;Lesion;Limb structure;Mediating;medication safety;Methylprednisolone;Microglia;Modeling;Molecular;Morphology;Motor;Motor Neurons;Muscle;Muscle Fibers;Muscle Proteins;muscle RING finger 1;Muscular Atrophy;Myelin;myelination;Myoblasts;nanoparticle;Nerve;Nervous System Trauma;neuroinflammation;Neurologic Deficit;Neurologic Dysfunctions;neuron loss;Neuronal Dysfunction;Neurons;Neurophysiology - biologic function;neuroprotection;novel;novel marker;Oligodendroglia;Paralysed;Patients;Penetration;pharmacologic;Phase;Plasma;Population;preservation;Prevention;Rattus;Recovery;Recovery of Function;reduced muscle mass;Rehabilitation therapy;research clinical testing;Safety;Signal Transduction;Skeletal Muscle;skeletal muscle wasting;Spinal Cord;Spinal Cord Contusions;Spinal cord injury;steroid hormone;Techniques;Testing;Tissues;Toxic effect;translational potential;Translations;Veterans

PROJECT_TITLE: Hormonal Intervention Protects Axon-myelin to Promote Functional Recovery in SCI


PHR: The pathophysiology of many diseases that are common in the Veteran population such as diabetes, multiple sclerosis, chronic fatigue syndrome, fibromyalgia, arthritis, asthma, and the metabolic syndrome is thought to be due in part to a “leaky gut”, an impairment of intestinal barrier function that enables toxic substances in the gut lumen to enter the systemic circulation. Our laboratory has discovered that bacterial toxins that are believed to help cause many of these syndromes enter into the body by a specific transport mechanism through the cells lining the intestine. In the studies proposed in this grant application, we plan to elucidate the specific mechanisms by which these toxins are absorbed, using mice that are deficient in specific transport pathways. We hope to translate these studies, into the discovery of new treatments that will help “tighten” the “leaky gut” with the hope of preventing or treating many of these diseases that commonly afflict Veterans.

PI_NAMEs: KAUNITZ, JONATHAN D. (contact)

PROJECT_TERMS: absorption;Acute;Adipose tissue;Affect;Alkaline Phosphatase;Anti-Inflammatory Agents;Applications Grants;Arthritis;Asthma;Bacterial Toxins;Caveolins;Cell Line;Characteristics;Chronic;Chronic Fatigue Syndrome;Chylomicrons;Circulation;Cirrhosis;Clathrin;Clinical;Diabetes Mellitus;Dietary Fats;Dietary Supplementation;Disease;Drug Metabolic Detoxication;Duodenum;Endotoxemia;Enterocytes;Fatty acid glycerol esters;Fibromyalgia;Functional disorder;glucose transport;gut microbiome;gut-liver axis;Hepatic;Impairment;Inflammatory;Ingestion;Insulin Resistance;Intervention;intestinal barrier;Intestines;Laboratories;Leaky Gut;Link;lipid structure;Lipids;Lipopolysaccharides;liver inflammation;Lymphatic;Mediterranean Diet;Metabolic;metabolic endotoxemia;Metabolic syndrome;microbial;military veteran;Modeling;Morbidity - disease rate;mouse model;Multiple Sclerosis;Mus;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Pathogenesis;Pathway interactions;Permeability;Poison;Polyunsaturated Fatty Acids;Population;Portal vein structure;prevent;Saturated Fatty Acids;Small Intestines;solute;Structure;Syndrome;systemic inflammatory response;Testing;Toxin;Translating;Triglycerides;uptake;Veterans

PROJECT_TITLE: Luminal Factors Affecting Duodenal Protection and Chemosensing


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: NARRATIVE While pancreatic cancer (PaC) survival rates have been modestly improving from decade to decade, the disease is still considered largely incurable, and therefore, there is an urgent need for new, effective and safe medications for PaC. ABTL0812 is a novel small molecule with anti-cancer activity through a novel mechanism of action. This application proposes to conduct a phase I/II clinical trial to assess the efficacy and safety of ABTL0812 in combination with the standard of care chemotherapy gemcitabine and nab-paclitaxel in patients with advanced metastatic PaC at first line therapy.

PI_NAMEs: SOHAL, DAVENDRA  (contact)

PROGRAM_OFFICER_NAME: RUBIO, TERESA

PROJECT_TITLE: Phase I/II clinical evaluation of ABTL0812, a novel PI3K/Akt/mTOR inhibitor, with a unique mechanism of action inpancreatic cancer (Protocol sent on 20th June 2019 as an amendment of the IND 137394)


ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

ORG_STATE: CO

PHR: Veterans comprise an elevated percentage of those with diabetes and subsequently have an increased risk of cardiovascular disease (CVD). We and others show that perivascular adipose tissue (PVAT), brown adipose tissue (BAT) that surrounds blood vessels, regulates vascular function differently between sexes. We demonstrate that housing animals at thermoneutrality causes PVAT to change from BAT to white adipose tissue (WAT), causing impaired vascular and cellular function in a sex-dependent manner. PVAT transformation and the resultant impact on vascular function is a novel pathogenic mechanism that may inform the biological underpinnings of sex difference in CVD progression. As the role of PVAT in vascular regulation has only been partially explored, understanding this pathology has translational potential for treating and preventing Veteran CVD in both men and women.

PI_NAMEs: KELLER, AMY CELESTE (contact)

PROJECT_TERMS: adipokines;adiponectin;Adipose tissue;Adrenergic Agents;Animal Housing;Animal Model;Animals;Aorta;Back;beta-adrenergic receptor;Biological;blood pressure regulation;Blood Vessels;Brown Fat;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;Cardiovascular Pathology;Cell Physiology;Cessation of life;Chronic;cold temperature;constriction;Data;Diabetes Mellitus;Disease Progression;endothelial dysfunction;Endothelium;Estrogens;Exposure to;Fatty acid glycerol esters;Fatty Acids;Female;Functional disorder;Genetic;Health;Hospitalization;Housing;Human;Hypertension;Impairment;In Vitro;insight;Investigation;Lipids;male;Measures;men;Metabolism;metabolomics;Mitochondria;mitochondrial metabolism;Modality;Nitric Oxide;Norepinephrine;novel;Nutrient;Obesity;Ovariectomy;oxidation;Paracrine Communication;Pathogenicity;Pathology;Performance;Phenotype;Physiology;Population;prevent;Production;Rattus;receptor;Regulation;repaired;Respiration;response;Role;sex;sex as a biological variable;Sex Differences;Signal Pathway;Signal Transduction;Temperature;Testing;Tissue Transplantation;Tissues;translational potential;United States;Vascular Diseases;Vascular Endothelium;Vasodilation;Vasodilator Agents;Veterans;Woman

PROJECT_TITLE: Delineating Mechanisms of Impaired Vasoreactivity in Thermoneutrality


NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

PHR: This project is aimed at improving the treatment of malaria. Resistance to current medicines makes drug combinations a requirement for treatment, but the best mixture of drugs to use is not easily discovered. The proposed work will use an apparatus, sometimes called a "glass mouse", to understand how best to design drug combinations for malaria.

PI_NAMEs: SHAPIRO, THERESA A (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Address;Affect;African;Animal Model;Anti-Bacterial Agents;Anti-Infective Agents;Anti-malarial drug resistance;Anti-malarials;Antimycobacterial Agents;Antiprotozoal Agents;Artemisinins;atovaquone;benflumetol;Budgets;cell type;Cells;Chloroguanide;Clinical;Clinical Trials;clinically relevant;Combination Drug Therapy;Consumption;cost;Data;Dose;drug action;Drug Approval;drug candidate;Drug Combinations;Drug Design;drug discovery;Drug Exposure;Drug Kinetics;Drug resistance;Drug usage;drug-sensitive;Elements;Evaluation;experimental study;Exposure to;Fiber;Foundations;Funding;Genotype;Glass;Goals;Grant;Growth;human model;improved;In Vitro;Individual;individual patient;Kinetics;Knowledge;Malaria;Measures;Medicine;Methods;mouse model;Mus;mutant;novel;novel therapeutics;Parasite resistance;Parasites;Parents;Pattern;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;Pharmacotherapy;Phenotype;Physiologic pulse;Plasmodium falciparum;Population;preference;pressure;prospective;Protozoa;Public Health;Publishing;Regimen;Reporting;Resistance;Resources;Role;Source;Study models;System;Techniques;Testing;Time;Trypanosoma;Work

PROJECT_TITLE: Essential PK/PD relationships of antimalarial drugs

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: LA JOLLA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Increased activity of cancer-causing genes (onco-genes) is often due to increased copy numbers mediated by extrachromosomal DNA (ecDNA). We propose to enhance our software and algorithms for elucidating the structure, function, and evolution of ecDNA and make them available to the research community as user- friendly tools. The resulting resource will enable advances in ecDNA biology and help identify new therapeutic vulnerabilities in currently intractable cancers.

PI_NAMEs: BAFNA, VINEET  (contact);MESIROV, JILL P.

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Address;Adoption;Algorithms;anti-cancer research;Architecture;automated segmentation;Biology;Centromere;chromothripsis;cloud platform;Cloud Service;Collaborations;Communities;Community Outreach;computational platform;computer infrastructure;Computer software;Computing Methodologies;Data;Dedications;deep neural network;Democracy;design;Development;Diagnostic;DNA analysis;DNA Repair;Drug resistance;Ecosystem;Education and Outreach;Environment;Evolution;extrachromosomal DNA;Feedback;Genes;Genetic Heterogeneity;genome sequencing;Genomics;Goals;Heterogeneity;High Performance Computing;Hour;improved;Lead;Letters;Libraries;Malignant Neoplasms;Maps;Mediating;Memory;Metaphase;Methods;nanopore;Nature;Normal Cell;novel;novel therapeutics;Oncogenes;Optics;outreach;Pathogenicity;patient prognosis;reconstruction;Research;Resources;Running;Sampling;single molecule;Stains;Structure;supercomputer;technology platform;tool;tumor;Tumor Promotion;user-friendly;Visualization;whole genome;Work

PROJECT_TITLE: Software and algorithms for elucidating the structure, function, and evolution of extrachromosomal DNA


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Prevention;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Over 30 million Americans have diabetes, and 1 in 6, over 5 million, report food insecurity, or insufficient access to enough food for an active, healthy life. The proposed research program will significantly advance our understanding of how to best address food insecurity in the context of diabetes management by testing an innovative medically-tailored meal delivery intervention for individuals with food insecurity and elevated blood sugar levels. This intervention has the potential to improve health and reduce the impact of food insecurity among vulnerable individuals with diabetes.

PI_NAMEs: BERKOWITZ, SETH A (contact)

PROGRAM_OFFICER_NAME: RAJAPAKSE, NISHADI

PROJECT_TERMS: Address;Adult;Affect;Aftercare;American;Asian ancestry;Attention;Behavior;Behavioral;Blood Glucose;Body mass index;Caring;Clinical;Cognitive;Communities;Complement;Complications of Diabetes Mellitus;contextual factors;Data;design;diabetes control;diabetes distress;diabetes management;Diabetes Mellitus;diabetes self-management;Diet;Dietitian;Dimensions;Disease;Disparity;disparity reduction;Distress;Economically Deprived Population;Education;Educational Intervention;efficacious intervention;efficacy evaluation;Enrollment;ethnic minority;Ethnic Origin;evidence base;experimental study;Food;Food Access;food insecurity;food preparation;food quality;Future;Glycosylated hemoglobin A;group intervention;Health;Health Food;Health Policy;health related quality of life;Healthy Eating;Home;Hypoglycemia;improved;indexing;Individual;innovation;Intervention;intervention delivery;intervention program;Interview;Knowledge;Life;lifestyle intervention;low socioeconomic status;Measures;Mediating;Medicaid;Medical;Medicine;Mental Health;Methods;Modification;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Nutritional;Nutritionist;Outcome;Participant;Pathway interactions;Patient Care;Patient Outcomes Assessments;Pharmaceutical Preparations;Physiological;Positioning Attribute;prevent;primary outcome;programs;psychologic;Psychological Factors;psychosocial;Quality of life;Race;racial minority;Randomized;randomized trial;randomized, clinical trials;recruit;Reporting;Research;Resources;response;Risk Factors;secondary analysis;secondary outcome;Self Efficacy;Self Management;skills;socioeconomic disadvantage;Socioeconomic Factors;Stress;Testing;Time;treatment as usual;treatment effect;Variant;Vulnerable Populations;Weight;Work

PROJECT_TITLE: Food is Medicine: A Randomized Clinical Trial of Medically Tailored Meals For Individuals with Type 2 Diabetes Mellitus and Food Insecurity

STUDY_SECTION: CIDO

STUDY_SECTION_NAME: Clinical and Integrative Diabetes and Obesity Study Section[CIDO]