NIH_SPENDING_CATS: Aging;Kidney Disease

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Public Health Relevance: Chronic kidney injury represents a major public health burden worldwide. This grant investigates the role of dysregulated mitochondrial electron transport-dependent tricarboxylic acid cycle metabolism in the pathogenesis of chronic kidney injury. Studies proposed under this grant will provide novel and fundamental insights into the metabolic functions of mitochondrial electron transport in kidney physiology and pathogenesis, and ultimately aim at identifying metabolic targets that can be exploited therapeutically for the prevention and therapy of kidney diseases.

PI_NAMEs: HAASE, VOLKER HANS (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Address;Adult;age-related disease;Aging;aging process;alternative oxidase;amino acid metabolism;Amino Acids;Animal Genetics;Animal Model;Apoptosis;Applications Grants;Binding Proteins;Carbon;Cell Differentiation process;cell injury;Cell Proliferation;Cell Separation;cell type;Cells;Chronic;Chronic Disease;Chronic Kidney Failure;Ciona intestinalis;Citric Acid Cycle;Coenzyme Q10;Complex;Cre lox recombination system;cytochrome c;Cytosol;Data;Degenerative Disorder;Development;Diabetic Nephropathy;Disease;electron energy;Electron Transport;Electron Transport Complex III;Electrons;Epigenetic Process;Epithelial Cells;Epithelium;Fatty Acids;feature detection;Fibrosis;Functional disorder;Future;Gene Expression Regulation;Generations;Genetic;genetic approach;Genetic Models;Glucose;Grant;Hypoxia Inducible Factor;In Vitro;in vivo;Inflammation;Injury to Kidney;insight;Kidney;Kidney Diseases;kidney fibrosis;Knock-out;Knockout Mice;Knowledge;Laboratories;Limb structure;Link;macromolecule;mass spectrometric imaging;Metabolic;Metabolic Pathway;Metabolism;Mitochondria;mitochondrial dysfunction;Modeling;mouse model;Mus;Nephrons;novel;Organ;Organelles;Oxidases;Oxidative Phosphorylation;Oxygen;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Physiology;Play;Prevention;Production;Proliferating;Public Health;public health relevance;Reactive Oxygen Species;renal epithelium;Research Project Grants;Research Proposals;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Site;Superoxides;superresolution microscopy;Tetracyclines;Therapeutic;Thick;Three-Dimensional Imaging;Tissue imaging;Tricarboxylic Acids;ubiquinol;ubiquinone-binding proteins;Urochordata

PROJECT_TITLE: Mitochondrial electron transport dysfunction: Dissecting pathomechanisms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-W(05)]


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Pediatric

ORG_CITY: MADISON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The developing visual system undergoes a postnatal period of synaptic refinement when neural circuits are structurally and functionally established. Our work will reveal how key divergent neural circuits within the primate retina reach functional and synaptic maturation in the postnatal period. Our findings will provide novel insights into the developmental trajectory of postnatal maturation for primate retinal pathways, thereby contributing to our understanding of visual dysfunction that arise from developmental disorders.

PI_NAMEs: HOON, MRINALINI ;SINHA, RAUNAK  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: 3-Dimensional;Address;Adult;Biological Models;biophysical properties;Birth;cell type;Cells;Communication;Development;developmental disease;Disparate;electrical property;Electron Microscopy;Electrophysiology (science);Event;Exhibits;Functional disorder;functional mimics;Goals;human stem cell-derived;insight;Knowledge;Light;light microscopy;luminance;Maps;Mediating;Modeling;Morphology;motion sensitivity;neural;neural circuit;Neurodevelopmental Disorder;neuronal circuitry;Neurons;novel;Output;parallel processing;Pathway interactions;Peripheral;Photophobia;Photoreceptors;Physiology;postnatal;postnatal development;postnatal period;postsynaptic;presynaptic;Primates;Process;Property;Proteins;Resolution;response;Retina;Retinal Degeneration;Retinal Ganglion Cells;retinal neuron;Rodent;Rodent Model;segregation;Sensory;Shapes;Signal Transduction;Synapses;Testing;timeline;Vision;Visual;visual dysfunction;Visual Pathways;Visual System;Work

PROJECT_TITLE: Circuit maturation and function in postnatal primate retina

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: WOODS HOLE

ORG_NAME: MARINE BIOLOGICAL LABORATORY

ORG_STATE: MA

PHR: PROJECT NARRATIVE Horizontal gene transfer is the movement of genetic material between organisms that differs from vertical transfer, the usual way of transmission from parents to offspring. While it is prevalent in bacteria, it occurs only rarely in multicellular animals. We are investigating the ways in which it can re-shape the evolution and biological properties of metazoans capable of capturing genes from representatives of other kingdoms and domains of life, and the means by which genetic information can be transferred through the well-protected metazoan germ line.

PI_NAMEs: ARKHIPOVA, IRINA  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Animals;Bacteria;Base Sequence;Biochemical;Biological;Cell division;Centromere;Characteristics;Chromatin;Chromosome Structures;Chromosomes;Code;comparative genomics;Complex;Custom;Cytogenetics;dietary;Distal;DNA;DNA Transposable Elements;Environment;Environmental Exposure;environmental stressor;Enzymes;Epigenetic Process;Eukaryota;Event;Evolution;fungus;Genes;genetic information;Genetic Materials;Genome;Genomic approach;Germ Lines;Goals;histone methyltransferase;Histones;Horizontal Gene Transfer;Immune response;Individual;innovation;Introns;Invertebrates;Investigation;Life;Link;Methylation;Methyltransferase;Mobile Genetic Elements;Molecular;Movement;novel;offspring;Organism;Parents;pathogenic fungus;Plants;Poison;polymerization;Polymers;Population;preference;prevent;Process;Property;Proteins;Recording of previous events;Reporting;Ribosomes;RNA;RNA-Directed DNA Polymerase;Role;Rotifera;sample fixation;Shapes;Sister;Source;Specificity;Spliceosomes;Stretching;System;Tandem Repeat Sequences;Taxon;Technology;telomere;Testing;therapeutic target;Time;transmission process;Trees;Variant;whole genome

PROJECT_TITLE: Horizontal gene transfer as the source of evolutionary innovation in eukaryotes

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Digestive Diseases;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Liver Disease;Nutrition;Obesity;Racial and Ethnic Minority Health Research;Rehabilitation

ORG_CITY: PITTSBURGH

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PUBLIC HEALTH RELEVANCE: Excess fat can accumulate ectopically in the liver and muscle, has negative metabolic consequences, and differentially impacts specific racial/ethnic subgroups of older adults. This project seeks to measure plasma lipidomics (>1000 lipids) and use existing computed tomography scans of the abdo- men to provide a better understanding of the biology of muscle and liver adiposity among Black Caribbeans, Black Americans, and White Americans. This study will provide evidence of lipid pathways associated with muscle and liver adiposity and differences in these pathways among individuals of varying degrees of African admixture to help elucidate important racial disparities in health outcomes.

PI_NAMEs: MARRON, MEGAN MICHELLE (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Abdomen;Activities of Daily Living;Address;Adipocytes;Admixture;African;African ancestry;African Caribbean;Age;Aging;aging related;American;bean;Behavior;Behavioral;Biochemical;Biochemistry;Biological;Biology;Biomechanics;Black American;Black race;Body Composition;Carbohydrates;caucasian American;Cell Physiology;Chronic;cohort;Coronary Artery Risk Development in Young Adults Study;Data;design;Diabetes Mellitus;disability;Drug Metabolic Detoxication;Elderly;Energy Metabolism;Environment;epidemiology study;Ethnic Origin;Ethnic Population;European ancestry;Fast-Twitch Muscle Fibers;Fatty acid glycerol esters;fatty acid oxidation;Fatty Acids;Funding;Gender;geographic difference;Glucose;Goals;Health;health disparity;Hepatic;High Prevalence;Homeostasis;Impairment;Individual;Infiltration;Inflammation;Insulin;Insulin Resistance;Intervention;Isotopes;K-Series Research Career Programs;Knowledge;Laboratories;Leadership;Left;lipid metabolism;lipidomics;Lipids;Lipolysis;Liver;Measures;Mentorship;Metabolic;Metabolic Pathway;metabolomics;Methods;Mobility disability;mortality;multidisciplinary;Muscle;muscle aging;muscle form;National Institute on Aging;novel;novel marker;Obesity;older adult;Organ;Outcome;Participant;Pathogenicity;Pathway interactions;Phenotype;Physical Function;physically handicapped;Physiological Processes;Plasma;Population;population based;preservation;Prevalence;Principal Investigator;Process;programs;Proteins;Protocols documentation;public health relevance;Race;racial difference;racial health disparity;Research;Research Personnel;saturated fat;Saturated Fatty Acids;Scanning;Secure;Skeletal Muscle;skills;Specificity;Techniques;Technology;Time;Tobago;Training;Triglycerides;uptake;Walking;X-Ray Computed Tomography

PROJECT_TITLE: Application of plasma lipidomics to identify novel biomarkers of muscle and hepatic adiposity in population-based cohorts of older Black Caribbeans, Black Americans, and White Americans

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Lung;Prevention

ORG_CITY: BERKELEY

ORG_NAME: AEROSOL DYNAMICS, INC.

ORG_STATE: CA

PHR: Project Narrative To accurately assess the risk of Airborne transmission of viral respiratory diseases, we need to not only identify the route of transmission (droplet or aerosol) for respiratory viruses but also whether the viruses are infectious (“viable, live”). This proposal presents a novel instrument for assessment of the different transmission modalities by separating airborne virus-containing particles by size and collecting them into liquid medium to conserve their viability, with the goal of determining the preferential particle sizes containing infectious viruses. Successful development of the proposed sampler will result in a powerful tool that allows better understanding of how viral respiratory diseases are spread through the air.

PI_NAMEs: EIGUREN FERNANDEZ, ARANTZAZU  (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 5 year old;Address;Aerosols;Affect;Air;air sampling;Area;Assessment tool;Biological;burden of illness;Cause of Death;Cells;Certification;Cessation of life;Chickens;Child;Clinical;Collection;Communicable Diseases;Communities;COVID-19;COVID-19 pandemic;Desiccation;design;Detection;Development;disability-adjusted life years;Disease Outbreaks;disorder control;Dose;Environment;Environmental Risk Factor;Equipment;experience;Exposure to;Farm;field study;Genomic DNA;genomic RNA;Goals;health care settings;health organization;Health Policy;Healthcare;Home;Hospitals;Hour;Humidity;Hygiene;improved;Individual;Infection;Influenza A Virus, H1N1 Subtype;Intervention;Knowledge;Laboratories;laboratory experiment;Liquid substance;Lower Respiratory Tract Infection;Measures;Methods;Microbe;microorganism;Modality;Modeling;Monitor;Morbidity - disease rate;mortality;novel;Nucleic Acids;Organism;pandemic preparedness;particle;Particle Size;Particulate;Particulate Matter;pathogen;pathogenic microbe;Pathogenicity;Performance;Phase;Physical condensation;Policy Maker;portability;Predisposition;Procedures;Protocols documentation;prototype;Public Health;Recommendation;Reporting;Respiratory Disease;respiratory pathogen;Respiratory Tract Infections;respiratory virus;Risk Assessment;RNA;Route;Sampling;Science;simulation;Social Distance;Students;Surface;System;Technology;Temperature;Testing;Time;tool;Training;transmission process;Tube;Upper Respiratory Infections;Validation;Viral;viral detection;viral transmission;Virus;Visit

PROJECT_TITLE: Biocascade inlet


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) is the most prevalent age-related neurodegenerative disease with underlying pathophysiological mechanisms remaining largely elusive. We will generate mechanistic hypotheses underlying AD with computational techniques and will validate top candidates by performing functional experiments in iPSC-derived excitatory neurons, microglia, and forebrain organoids.

PI_NAMEs: GAN, LI ;LI, YUN  (contact);SHEN, YIN

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: 3-Dimensional;Address;Affect;age related neurodegeneration;Alzheimer's Disease;Alzheimer's disease risk;Astrocytes;Base Pairing;bioinformatics tool;Biological Assay;Biological Process;Brain;brain cell;Brain imaging;candidate validation;causal variant;cell type;Cells;Central Nervous System;Cerebrum;Chromatin Conformation Capture and Sequencing;Chromatin Loop;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;computational suite;Computational Technique;Computing Methodologies;Creativeness;CRISPR interference;Data;Dementia;differential expression;Disease;Distal;DNA;Elderly;Elements;epigenomics;excitatory neuron;experimental study;follow-up;functional genomics;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;genetic variant;Genome;genome sequencing;genome wide association study;genome-wide analysis;genomic data;Genotype;Heritability;imaging genetics;Individual;induced pluripotent stem cell;Knock-in;Knowledge;Measurement;Measures;Mediating;Microglia;Modeling;Molecular;Neurobiology;Neurons;Nucleic Acid Regulatory Sequences;Organoids;Pathogenesis;Pathway interactions;Phenotype;Physiological;Play;Population;programs;promoter;Prosencephalon;Protocols documentation;Regulation;Regulator Genes;Resolution;Role;Sampling;Signal Transduction;single-cell RNA sequencing;statistics;System;Techniques;Technology;Testing;therapeutic development;Tissues;Transcriptional Regulation;transcriptome;transcriptome sequencing;transcriptomics;Validation;Variant;whole genome;Work

PROJECT_TITLE: Study of Selective Cell and System Vulnerability in Alzheimer's Disease

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biomedical Imaging;Cardiovascular;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Heart Disease;Heart Disease - Coronary Heart Disease;Infectious Diseases;Lung;Pain Research;Physical Activity;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention

ORG_CITY: CHICAGO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE: This study seeks to discover the reason patients with long COVID suffer from persistent chest pain symptoms. Using advanced magnetic resonance imaging (MRI), this study will determine: (a) whether MRI accurately and precisely detects blockage in small blood vessels supplying oxygen to the heart in long COVID patients; (b) whether the said blockage is the cause of persistent chest pain symptoms in long COVID patients; (c) whether the said blockage resolves better if patients undergo therapy. Our findings will inform future clinical trials aimed at preventing and/or reversing persistent chest pain caused by long COVID.

PI_NAMEs: KIM, DANIEL  (contact);LEE, DANIEL CHING-HAO

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: acute COVID-19;Age;Americans with Disabilities Act;Arrhythmia;asymptomatic COVID-19;Biological Markers;Blood;Blood flow;Blood Vessels;Breathing;Cardiopulmonary;Cardiovascular Abnormalities;cardiovascular health;Cardiovascular system;Chest Pain;Chronic;Cicatrix;Classification;Clinical;Clinical Trials;Contrast Media;Control Groups;Coronary;Coronary Arteriosclerosis;cost;COVID-19;COVID-19 patient;COVID-19 survivors;Data;Detection;Development;Diagnosis;Diagnostic;Diagnostic Imaging;Diagnostic tests;Diffuse;disability;Endothelium;Enrollment;Ethnic Origin;exercise capacity;exercise intolerance;Exercise Test;extracellular;Fibrosis;Functional disorder;Future;Gadolinium;Goals;Grant;Healthcare;Heart;Heart Diseases;heart imaging;hemodynamics;Image;imaging facilities;imaging modality;improved;indexing;Inflammation;Injury;Ionizing radiation;Ischemia;Knowledge;Left Ventricular Ejection Fraction;Long COVID;Lung;Magnetic Resonance;Magnetic Resonance Angiography;Magnetic Resonance Imaging;Matched Case-Control Study;Measures;Medical Imaging;Microvascular Dysfunction;Modality;Myocardial;Myocardial perfusion;Oxygen;pain patient;pain symptom;Patients;Perfusion;perfusion imaging;Pericardial body location;persistent symptom;Positioning Attribute;post SARS-CoV-2 infection;Post-Acute Sequelae of SARS-CoV-2 Infection;prevent;Protocols documentation;pulmonary function;Race;Radioactive Tracers;Recording of previous events;Resources;Risk Factors;SARS-CoV-2 infection;Severities;sex;Stress;Symptoms;Testing;Time;tomography;United States National Institutes of Health;Vaccines

PROJECT_TITLE: Quantitative Detection of Coronary Microvascular Dysfunction in Long COVID Patients using a Comprehensive, Rapid, Free-Breathing Cardiovascular MRI

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: Chicago

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE Deficits in executive functioning (EF) disproportionately impact children living in poverty and increase risk for psychopathology, particularly disruptive behavior disorders. This randomized clinical trial seeks to determine whether childhood EF, assessed across neural and behavioral units of analysis, is an experimental therapeutic target that can be directly modified through caregiver participation in the Chicago Parent Program (CPP), if increases in EF predict reduced disruptive behavior trajectories in low-income children over a short-term follow-up period, and identify which CPP-driven parenting skill improvements are the most influential in modifying EF. This work will contribute new knowledge as to whether a cost-efficient parenting intervention, developed for and with low-income families raising young children in poverty, can modify EF, a neural- behavioral mechanism implicated in risk for childhood disruptive behavior problems.

PI_NAMEs: SUOR, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: 5 year old;Address;Adolescence;affective neuroscience;Aftercare;Age;Area;Award;Behavior;Behavioral;Behavioral Mechanisms;Brain;brain behavior;career;career development;Caregivers;Chicago;Child;Child Rearing;Childhood;Chronic;clinical translation;Clinical Trials;cognitive control;cognitive performance;cognitive process;cognitive task;collaborative environment;community based research;Community Mental Health Services;comparison control;Conduct Disorder;Control Groups;cost efficient;Data;design;Development;Diagnostic;diagnostic criteria;Discipline;Disruptive Behavior Disorder;dissemination science;early childhood;Electroencephalography;Eligibility Determination;Enrollment;Ensure;Etiology;Evaluation;Executive Dysfunction;executive function;experience;Family;follow-up;Goals;health disparity;Health Services Research;Illinois;Impairment;implementation science;improved;indexing;Individual Differences;Influentials;Informal Social Control;Interview;Investigational Therapies;Knowledge;life span;Link;Low income;lower income families;Measures;Mediating;Medicaid eligibility;Mental disorders;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Modification;Monitor;National Institute of Mental Health;neural;Neuronal Plasticity;neurophysiology;novel;Nursery Schools;Oppositional Defiant Disorder;parental influence;parenting intervention;Parents;Phase;Poverty;Prediction of Response to Therapy;prevent;Prevention program;preventive intervention;Problem behavior;programs;protective effect;Psychiatry;Psychopathology;psychosocial;Publishing;Randomized;randomized, clinical trials;Recording of previous events;recruit;Reporting;Research;Research Domain Criteria;Risk;Sampling;scaffold;Scientist;skills;Stress;Surveys;Testing;theories;therapeutic target;Time;Training;Universities;Work;Youth

PROJECT_TITLE: Improving Brain-Behavior Markers of Preschool Executive Function through aGroup-Based Parenting Intervention for Low-Income Families


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: We will determine whether deletion of a Parkinson disease (PD)-associated, regulatory sequence from an intron of the PD gene, alpha synuclein, influences disease onset or severity, in a novel, engineered mouse model. We will characterize the histological, non-motor and motor phenotypes of the model, in the absence and presence of established genetic and cellular insults known to elicit clinical symptoms and progressive dopamine neuronal loss in mice. Our work will reveal the pathological relevance of this sequence and inform the mechanistic role of PD-associated regulatory variants in modulating PD risk, severity and progression, and highlight new avenues for therapeutic development.

PI_NAMEs: KO, HANSEOK ;MCCALLION, ANDREW S (contact)

PROGRAM_OFFICER_NAME: SWANSON-FISCHER, CHRISTINE R

PROJECT_TERMS: Age;Age Months;alpha synuclein;Automobile Driving;Behavioral;behavioral phenotyping;Biological;Biological Assay;Cells;Chromatin;Cis-Acting Sequence;Clinical;clinically relevant;Data;Disease;disease phenotype;Disease Progression;disorder risk;dopaminergic neuron;Engineering;Enhancers;Equilibrium;Exhibits;Exposure to;Fluorescent in Situ Hybridization;Functional disorder;Gene Amplification;Genes;Genetic;Genetic study;Genetic Transcription;Genotype;glial activation;Heterozygote;Histologic;Homozygote;Human;Immunohistochemistry;Inflammation;Injections;Introns;Knockout Mice;Lewy Bodies;Midbrain structure;Modeling;molecular phenotype;Motor;mouse model;Mus;mutant;Mutate;Mutation;Nerve Degeneration;neuron loss;Neurons;neurotoxic;novel;novel therapeutics;olfactory bulb;Onset of illness;Orthologous Gene;Oxidopamine;Parkinson Disease;Parkinsonian Disorders;Pathologic;Pathology;Phenotype;phenotypic data;Population;pre-formed fibril;promoter;protein misfolding;Reporter;Risk;Risk Factors;Risk Reduction;risk variant;RNA Splicing;Role;Severities;Severity of illness;single molecule;Smell Perception;SNCA gene;sporadic Parkinson's Disease;Symptoms;Techniques;Testing;Tetanus Helper Peptide;Tetracyclines;therapeutic development;Titrations;Transcript;Transcriptional Regulation;Transgenic Mice;Untranslated RNA;Variant;Viral Vector;Work

PROJECT_TITLE: Determination of the clinical relevance of Parkinson disease-associated intronic enhancer of the alpha-synuclein gene, in a novel mouse deletion model

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Neurosciences

ORG_CITY: OMAHA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE Staphylococcus aureus (S. aureus) is responsible for the majority of craniotomy-associated infections, where it forms a biofilm on the bone flap that is recalcitrant to antibiotics and evades immune clearance. Combined infection and injury from the surgical procedure leads to a mixture of pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) in the local tissue environment, which are both sensed by triggering receptor expressed on myeloid cells-2 (TREM2). This proposed research will investigate the molecular and metabolic mechanisms by which TREM2 mediates an anti-inflammatory immune cell response and S. aureus immune evasion to promote biofilm growth.

PI_NAMEs: KORSHOJ, LEE ERIK (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Agreement;Alzheimer's Disease;Aneurysm;Animals;Anti-Inflammatory Agents;antibiotic tolerance;Antibiotics;Attenuated;Bacteria;Binding;bone;Brain;cell type;Cells;Chronic;Clip;Coculture Techniques;comparative;Craniotomy;cranium;cytokine;Development;Disease;DNA;Environment;Epilepsy;Excision;experimental study;Exposure to;Future;Gene Expression;Genes;Glycolipids;Growth;Heterogeneity;human disease;Immune;immune clearance;Immune Evasion;Immune system;Immunity;improved;In Vitro;in vivo;Individual;Infection;Inflammation;Inflammatory Response;insight;Invaded;Knockout Mice;Laboratories;Leucocytic infiltrate;Leukocytes;Ligand Binding;Ligands;Lipopolysaccharides;Lipoproteins;lipoteichoic acid;Mediating;Membrane;Metabolic;Metabolism;Microbial Biofilms;Microglia;Modeling;Molecular;Morbidity - disease rate;mouse model;Mus;mutant;Mutation;Nervous System Disorder;Neurologic;Neurosurgeon;neurosurgery;novel;Operative Surgical Procedures;Parkinson Disease;pathogen;pathogenic bacteria;Pathology;Patient-Focused Outcomes;Patients;Pattern;Pattern recognition receptor;Peptidoglycan;Phagocytosis;Phospholipids;Play;Population;Procedures;Production;Proliferating;Prosthesis;receptor;Receptor Signaling;recruit;Regulation;Reporting;Research;response;Risk Factors;Role;Signal Induction;Signal Transduction;single-cell RNA sequencing;Staphylococcus aureus;Staphylococcus aureus infection;Sterility;subcutaneous;Surgical Injuries;targeted treatment;Techniques;Testing;Therapeutic Intervention;therapeutic target;Tissues;Toll-like receptors;transcriptomics;TREM2 gene;tumor;Up-Regulation;Virulence Factors;Work;wound healing

PROJECT_TITLE: TREM2 senses both pathogen- and damage-associated molecular patterns to promote S. aureus craniotomy infection

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Epilepsy;Neurodegenerative;Neurosciences

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Alzheimer's disease is the most common form of dementia and the sixth leading cause of death in the U.S., but this devastating disease has no cure. Currently, 5.7 million Americans are living with Alzheimer's disease and 1 in 3 seniors die from dementia, which is more than breast cancer and prostate cancer combined. This research will reveal novel insights on the functional abnormalities of neurons that underlie cognitive impairment in Alzheimer's disease.

PI_NAMEs: MA, KERAN  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Affect;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease therapeutic;American;APP-PS1;Award;Bacterial Artificial Chromosomes;Behavior;Behavior assessment;Behavioral;Brain;Calcium;Cause of Death;Cell Physiology;cell type;Cells;Chronic;Cognition;Cognitive;cognitive function;cognitive task;Collaborations;Color;Data;Dementia;Development;Disease;Electroencephalography;Environment;epileptiform;Event;excitatory neuron;Exhibits;experience;falls;FDA approved;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;functional outcomes;Genetic;Goals;Head;Hour;Image;Impaired cognition;Impairment;improved;in vivo;in vivo calcium imaging;in vivo two-photon imaging;innovation;insight;Interneuron function;Interneurons;J20 mouse;Laboratories;Link;Literature;Locomotion;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Measures;Memantine;Mentors;Motor Activity;mouse model;Mus;network dysfunction;Neurofibrillary Tangles;Neurons;non rapid eye movement;novel;overexpression;Parietal Lobe;Parvalbumins;Pathologic;Pathology;Pattern;Pharmaceutical Preparations;Phase;Play;Predisposing Factor;Property;Publishing;Research;Resolution;Rest;Role;Scalp structure;SCN1A protein;Seizures;Senile Plaques;Sleep;Sodium Channel;targeted treatment;Techniques;Telemetry;Therapeutic;Transgenes;Transplantation;voltage

PROJECT_TITLE: Functional Alterations of Parvalbumin Interneurons Contributing to Abnormal Network Activity in Alzheimer's Disease Mouse Models

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: ALBUQUERQUE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Project Narrative Regulation of blood pH within a narrow window is necessary to sustain life. We recently uncovered a novel and consequential role for a kidney receptor (Gpr116) to modulate how the kidney regulates blood pH. In these studies, we aim to better understand the role of Gpr116 in the kidney by uncovering the mechanism by which Gpr116-mediated regulation of pH occurs, and, by discovering how the activity of Gpr116 is regulated and controlled.

PI_NAMEs: ZAIDMAN, NATHAN A (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: Acids;Address;Adhesions;Agonist;Alkalosis;Animals;apical membrane;base;Binding;Biological;Biological Assay;biological systems;Blood;Cell membrane;Cell Separation;cellular microvillus;Cre lox recombination system;Data;detection assay;Disease;Disparate;Drug Targeting;Duct (organ) structure;Electrons;Elements;Endocytosis;Excretory function;Exons;experimental study;extracellular;Extracellular Domain;F-Actin;Family;FDA approved;Feedback;Fertility;G-Protein-Coupled Receptors;Glycocalyx;Glycoproteins;Goals;GTP-Binding Proteins;Hormones;Human Genome;Immunity;Immunoprecipitation;In Situ;inhibitor;Integral Membrane Protein;Intercalated Cell;interdisciplinary approach;Investigation;Investments;Kidney;Knock-out;Knockout Mice;Knowledge;Life;Light;luminal membrane;Lung;Mediating;member;Membrane;Metabolic acidosis;method development;Molecular;Mus;N-terminal;Neurotransmitters;novel;Odors;Pathway interactions;Peptides;Pharmacologic Substance;Phase;Phylogenetic Analysis;Physiological;Physiology;Platelet Activation;polymerization;Polymers;Polysaccharides;Process;Proteins;Proton Pump;Proton-Translocating ATPases;Publishing;Pulmonary Surfactants;receptor;Receptor Activation;Recovery;Regulation;Reporter;Reporting;Research;Research Project Grants;Retrieval;rho;rho GTP-Binding Proteins;rhotekin;Role;Sequence Homology;Signal Transduction;Signaling Protein;Site;Surface;synaptic function;Testing;Therapeutic;Time;Tissues;Transcript;transcriptome sequencing;transmission process;Tubular formation;tumor progression;Urine;Variant;Vesicle

PROJECT_TITLE: Gpr116 Regulation of Renal Acid Excretion

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Aging;Bioengineering;Complementary and Integrative Health;Dietary Supplements;Estrogen;Microbiome;Nutrition;Osteoporosis;Prevention;Women's Health Research

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: PROJECT NARRATIVE Complex interactions between physiological systems, as seen in the gastrointestinal, immune, and skeletal systems’ response to prebiotics, require systems approaches to integrate the many interconnected processes. This project combines experimental and computational systems approaches to explore how a dietary prebiotic can be used to regulate the gut-bone axis in estrogen deficiency. Project results will provide new insights into the immune system’s response to prebiotics and will produce a predictive mathematical model for mechanistic effects of the immune system in the gut-bone axis that will enable future optimization of prevention and treatment strategies targeting the gut for osteoporosis and other conditions associated with aging.

PI_NAMEs: FORD VERSYPT, ASHLEE NICOLE (contact)

PROGRAM_OFFICER_NAME: FLORES, ROBERTO L

PROJECT_TERMS: Address;Affect;Aging;aging related;aging related disease;Animal Model;Attenuated;Blood;bone;bone cell;bone loss;Bone Marrow;bone resorbing activity;Cell Line;cell type;Cells;Complex;Computer Models;computer studies;cost;cytokine;Data;Data Set;Dendritic cell activation;Dendritic Cells;design;dietary;Dietary Intervention;Differential Equation;Disease;effector T cell;Estrogen deficiency;Estrogens;Exclusion;experimental study;Fermentation;Flow Cytometry;Future;gastrointestinal system;Gene Expression Profile;gut microbiota;Histology;Homeostasis;hormone deficiency;Hormones;Immune;Immune response;Immune system;immunoregulation;improved;in silico;in vivo;Inflammatory;insight;Intervention;intestinal barrier;intestinal epithelium;Intestines;invention;Investigation;Literature;Lymphoid Tissue;mathematical model;Measurement;Mediating;Methods;microbiota;microorganism;Modeling;Mucous Membrane;Mus;Oligosaccharides;Osteoblasts;Osteoclasts;Osteoporosis;Outcome;Ovarian hormone;Ovariectomy;Peripheral;peripheral blood;Phenotype;Physiological;Play;Population;Postmenopausal Osteoporosis;prebiotics;prevent;Prevention strategy;Process;programs;Protein Analysis;Regulation;Regulatory T-Lymphocyte;response;Response to stimulus physiology;Role;Sampling;Signal Transduction;skeletal;Skeletal system;Stimulus;Supplementation;System;T cell differentiation;T cell response;T-Lymphocyte;Techniques;Testing;therapeutic target;tool;transcriptome sequencing;transcriptomics;Translating;treatment optimization;treatment strategy;Volatile Fatty Acids;Work

PROJECT_TITLE: Mathematical Modeling of the Impacts of Prebiotic Dietary Intervention on Immunomodulation During Estrogen Deficiency

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Cardiovascular;Conditions Affecting the Embryonic and Fetal Periods;Congenital Heart Disease;Congenital Structural Anomalies;Fetal Alcohol Spectrum Disorders (FASD);Genetics;Heart Disease;Intellectual and Developmental Disabilities (IDD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Rare Diseases;Substance Misuse

ORG_CITY: Los Angeles

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJEC NARRATIVE  The root cause for the majority of cases of congenital heart defects (CHD) cannot be explained by current research. There is an established risk for alcohol use during pregnancy resulting in CHD without mechanistic understanding of how alcohol disrupts heart development. This fellowship will allow for investigation into a large, modifiable CHD risk factor, paving the way for therapeutic and preventative interventions to reduce the leading cause of newborn death and driving cost for pediatric hospitalizations.

PI_NAMEs: HARVEY, DRAYTON C (contact)

PROGRAM_OFFICER_NAME: DUNTY, JR, WILLIAM

PROJECT_TERMS: Accidents;Acetylation;Acids;Acute;Address;Alcohol consumption;alcohol effect;alcohol exposure;alcohol risk;Alcohols;Apoptosis;Automobile Driving;Awareness;Biological Assay;Biology;Body System;Cardiac;cardiogenesis;Cementation;Chest;Childhood;Chronic;Clinical;Clinical Research;clinically relevant;Collaborations;Congenital Abnormality;Congenital Heart Defects;conotruncal heart defect;cost;Craniofacial Abnormalities;Critical Pathways;Data;Defect;Development;Diagnosis;disorder prevention;Doctor of Medicine;Doctor of Philosophy;drinking;Education;Ensure;epigenetic regulation;Ethanol;Exposure to;Fatal birth defect;Fellowship;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Frequencies;Genes;Genetic;Genetic Transcription;genome sequencing;Heart;Histologic;histone acetyltransferase;Histones;Hospitalization;human study;In Vitro;in vivo;Incidence;Individual;inhibitor;Institution;Intervention;Intraperitoneal Injections;Investigation;Ligands;Literature;Lysine;malformation;Mentorship;migration;Molecular;mouse model;Mus;Mutation;National Institute on Alcohol Abuse and Alcoholism;Nature;Neonatal Mortality;Neurologic;notch protein;novel;Organ;Organ Culture Techniques;Organogenesis;overexpression;Participant;Pathway interactions;Patients;permissiveness;Population;Pregnancy;prevent;Prevention;preventive intervention;Principal Investigator;progenitor;programs;Proliferating;Regression Analysis;Relative Risks;Reporting;Research;restoration;Reverse Transcription;Risk;Risk Factors;Role;Sampling;Severities;Signal Transduction;Site;Specific qualifier value;Specificity;synergism;Teratogens;Testing;Therapeutic Intervention;Time;Training;Validation;Variant;whole genome;Work

PROJECT_TITLE: Acute Prenatal Alcohol Exposure Potentiates Conotruncal Defects in the Setting of a Permissive Genetic Background


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: HEALTH RELEVANCE Identification of new, noninvasive routes for drug delivery to the brain would have a significant impact on our ability to translate new therapeutics into clinically viable drugs for the treatment of millions of patients who suffer from debilitating neurological diseases. In particular, delivery approaches coupling antibodies with BBB-selective transport systems would be no more invasive than an intravenous injection and allow delivery of a variety of drug cargoes including small molecules, genes, and proteins.

PI_NAMEs: SHUSTA, ERIC V (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Alzheimer's Disease;American;Antibodies;antibody libraries;Antibody Specificity;Antibody-drug conjugates;Binding;Biodistribution;Biological Products;Blood;Blood - brain barrier anatomy;Blood Circulation;blood-brain barrier crossing;blood-brain barrier permeabilization;Brain;Brain Diseases;Brain-Derived Neurotrophic Factor;Cells;Cerebrum;Characteristics;Clinical;Coupling;dalton;Data;delivery vehicle;Development;Diffuse;Disease;disease model;Dose;drug candidate;Drug Delivery Systems;drug development;Drug Efflux;Drug Kinetics;Drug Transport;efflux pump;Endothelium;Ensure;Exclusion;Exhibits;Fc Receptor;Generations;Genes;Health;Hematological Disease;high-throughput drug screening;Human;human induced pluripotent stem cells;human tissue;Immunoprecipitation;In Vitro;in vivo;innovation;Insulin;Insulin Receptor;intravenous administration;intravenous injection;Libraries;Link;lipophilicity;Liposomes;Low Density Lipoprotein Receptor;Malignant neoplasm of brain;Mediating;Medicine;Mining;Modeling;Monitor;Mus;nanoparticle;natural hypothermia;Nervous System Disorder;Neuropeptides;Neurotensin;novel;novel therapeutics;Parkinson Disease;Patients;Persons;Phage Display;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Pharmacologic Substance;Pharmacotherapy;pre-clinical;programs;Property;Proteins;Reagent;receptor;Research;response;Route;screening;Side;small molecule;small molecule therapeutics;Source;Specificity;Stroke;stroke model;System;tandem mass spectrometry;targeted delivery;targeted treatment;Techniques;Technology;Testing;TFRC gene;Therapeutic;therapeutic DNA;transcriptome;transcytosis;Transferrin;Translating;Translations;uptake;Validation;Vascular Endothelium

PROJECT_TITLE: New Human Antibodies for CNS Drug Delivery


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Obesity

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: With aging there is progressive accumulation of fat tissue. This study will examine, at the molecular level, the different cellular populations in fat tissue to improve our understanding about the mechanisms by which aging and obesity affect the health of adults as they age.

PI_NAMEs: MUSI, NICOLAS  (contact)

PROJECT_TERMS: Adipocytes;Adipose tissue;Adult;Affect;Age;Aging;aging related;aging related disease;Alzheimer's Disease;Atherosclerosis;Atlases;bioinformatics tool;Biology of Aging;Cell Aging;Cell Cycle Arrest;Cell Physiology;Cell surface;Cells;cohort;cytotoxicity;Dasatinib;Endothelial Cells;Etiology;Fatty acid glycerol esters;Functional disorder;Global Change;glucose tolerance;Health;Human;Immune;improved;Individual;Inflammation;innovation;insight;insulin sensitivity;Intervention;Laboratories;lifestyle intervention;Malignant Neoplasms;Maps;Mesenchymal Stem Cells;Metabolic;Metabolic Diseases;Metabolic dysfunction;Methodology;Methods;Molecular;Molecular Profiling;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;obese person;Obesity;Older Population;Outcome;Participant;Pharmaceutical Preparations;Play;Population;preservation;Property;Quercetin;Research;Resolution;response;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;single nucleus RNA-sequencing;single-cell RNA sequencing;stem;Stromal Cells;Subgroup;Testing;theories;Thinness;Tissues;tool;transcriptome;Variant

PROJECT_TITLE: Single nuclei RNA-sequencing to map adipose cellular populations and senescent cells in older subjects

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Contraception/Reproduction;Digestive Diseases;Liver Disease;Pregnancy;Women's Health Research

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: PROJECT NARRATIVE With an interdisciplinary team of placental toxicologists and biomedical engineers the proposed work will develop a 3-dimensional high-throughput platform for testing effects of chemicals and pharmaceuticals during pregnancy. The inclusion of liver biotransformation into the platform is the first step towards incorporating organism-level organization into placental risk assessment.

PI_NAMEs: KHETANI, SALMAN R (contact);VEIGA-LOPEZ, ALMUDENA

PROGRAM_OFFICER_NAME: RAVICHANDRAN, LINGAMANAIDU V

PROJECT_TERMS: 3-Dimensional;adverse outcome;Animal Model;Beds;Biological Availability;Biomedical Engineering;Blood Vessels;Cell Communication;Cell Line;Cell Physiology;cell type;Cells;Chemical Exposure;Chemicals;Coculture Techniques;Coupled;Data;Development;Drug Delivery Systems;Endocrine Disruptors;Endothelial Cells;Endothelium;Engineering;Ensure;Environment;Epidermal Growth Factor;Ethics;Evaluation;Extracellular Matrix;fetal;First Pregnancy Trimester;Future;Gel;Health;healthy pregnancy;Hepatic;Hepatic Stellate Cell;Hepatocyte;high dimensionality;high resolution imaging;high reward;high risk;high throughput screening;Human;human model;Hypoxia;Image Analysis;In Vitro;in vivo;in vivo Model;Integrins;Invaded;Investigation;Kupffer Cells;Liver;liver metabolism;Manuals;maternal wellbeing;Matrix Metalloproteinases;Measures;Mediating;Metabolic Biotransformation;Microfluidic Microchips;Microfluidics;Modeling;novel;Organ;organ on a chip;Organism;Pathway interactions;Pharmacologic Substance;Phenotype;Physiological;Placenta;Placental Biology;Pregnancy;Pregnancy Complications;Pregnancy Outcome;pregnant;Proliferating;Property;Reproducibility;reproductive;reproductive toxicity;response;Risk Assessment;screening;self assembly;Speed;spheroids;Stromal Cells;System;Testing;Time;Tissues;tool;toxicant;Toxicokinetics;Toxicology;trophoblast;United States Environmental Protection Agency;Woman;Work

PROJECT_TITLE: Development of a 3D hepatic-placental tandem organ-on-a-chip for toxicological screening

STUDY_SECTION: DBDT

STUDY_SECTION_NAME: Drug and Biologic Disposition and Toxicity Study Section[DBDT]


NIH_SPENDING_CATS: Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_NAME: AMERICAN PUBLIC HEALTH ASSOCIATION

ORG_STATE: DC

PHR: Project Narrative The program for the Environment Section at the 2023, 2024, and 2025 American Public Health Association Annual Meeting and Expos will benefit students. In particular, we aim to support underrepresented students defined as those coming from underserved populations, underrepresented institutions, or communities underrepresented in the field of environmental health in terms of economic, racial/ethnic, or other demographic characteristics. This funding would allow scholarship recipients the opportunity to discover the latest science, policy and practice in the field of environmental health; learn about efforts to address the health impacts of environmental exposures; network with leaders and peers in the field; and present their own work in environmental health.

PI_NAMEs: ROBB, KATE MARIE (contact)

PROGRAM_OFFICER_NAME: O'FALLON, LIAM

PROJECT_TERMS: Address;Advocacy;Advocate;American Public Health Association;Applications Grants;Area;Boston;career;Characteristics;climate change;Communities;Disadvantaged;disadvantaged background;Economics;Ensure;Environment;Environmental Exposure;Environmental Health;Environmental Impact;environmental justice;Environmental Protection;Equity;Ethical Issues;Ethics;Ethnic Origin;Event;Fostering;Funding;Future;Generations;Goals;Grant;Health;health equity;Health Professional;Hybrids;improved;Individual;Institution;interest;intergenerational;Justice;Leadership;Learning;Massachusetts;meetings;member;Mentorship;Mission;National Institute of Environmental Health Sciences;next generation;Pathway interactions;peer;Persons;Policies;posters;programs;Public Health;Race;racism;Research;Research Personnel;Role;Scholarship;Schools;Science;Scientist;social;Special Event;Strategic Planning;student conference;student participation;Students;symposium;Time;Underrepresented Students;Underserved Population;Washington;Work

PROJECT_TITLE: Conference Scholarships for APHA's 2023, 2024, & 2025 Annual Meetings to Support Underrepresented Students in Environmental Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 ARL-W (13)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: Carlsbad

ORG_NAME: ARISAN THERAPEUTICS, INC.

PHR: Narrative Given our current global community there is the possibility for the rapid emergence of infectious pathogens from any part of the world with the potential to cause excessive morbidity/mortality and widespread disruption of global economies and public healthcare systems . This proposal covers the further development for both drug substance and product manufacturing process for a highly effective broad-spectrum oral arenavirus (e.g. Lassa virus) antiviral drug to support Phase 3 clinical trial for Lassa Fever patients in Africa.

PI_NAMEs: HENKEL, GREGORY WILLIAM (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: Acceleration;Africa;analytical method;Anti-viral Agents;Appearance;Area;Arenavirus;Biological Assay;Biological Availability;Biological Sciences;capsule;catalyst;Categories;Category A pathogen;Charcoal;Clinical;Communities;cost;Cysteine;Data;Development;Dose;Encapsulated;Engineering;Evaluation;Excretory function;Family;Formulation;Geography;Grant;Half-Life;Healthcare Systems;Heptanes;Hospitalization;Human;improved;infected vector rodent;Infection;inhibitor;Lassa;Lassa Fever;Lassa virus;Length;manufacture;manufacturing process;Methods;Minor;Monograph;Morbidity - disease rate;mortality;Old World Arenaviruses;Oral;Organism;Palladium;pathogen;Patients;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;Phase III Clinical Trials;pill;Process;process improvement;process optimization;Production;prophylactic;Protocols documentation;Public Health;purge;Reaction;Records;research and development;Residual state;Solvents;Source;Specific qualifier value;Survivors;Tablets;Testing;Time;transmission process;Transplantation;Validation;Viral Hemorrhagic Fevers;Water;weapons;Weight;Western Africa;Work;Zoonoses

PROJECT_TITLE: Initiation of ARN-75039 API and Drug Product NDA Registration Path and Manufacturing of Phase 3 final Drug Product

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-K (19)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: American Indian or Alaska Native;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Rooted in colonialism, historical trauma, and structural racism, American Indian and Alaska Native (AI/AN) populations experience major disparities in substance use and related adverse outcomes—particularly AI/AN Veterans—but these disparities remain vastly understudied. Our team of Indigenous and non-Indigenous researchers and our rich foundation of substantial upfront investment from NIDA via a parent R01 create a unique opportunity to add an unprecedented and community-engaged line of inquiry into substance use and its treatment among AI/AN Veterans to support culturally-appropriate intervention development. We will conduct community-partnered clinical epidemiologic and qualitative research to inform development of a culturally appropriate and strengths-based intervention that addresses substance use among AI/AN Veterans in clinical settings and can be tested using a Hybrid Type I design to inform effectiveness and implementation.

PI_NAMEs: JENNINGS, DEREK R;WILLIAMS, EMILY CATERINA (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: addiction;Address;adverse outcome;Alaska Native;Alaska Native population;American;American Indian Population;American Indians;Cessation of life;Chronic;Clinical;clinical epidemiology;Colonialism;Communities;community engagement;community partners;culturally appropriate intervention;Data;design;Development;Disparity;Effectiveness;epidemiology study;Evidence based treatment;experience;Foundations;Goals;Health;health care disparity;hybrid type 1 design;hybrid type 1 study;Hybrids;Indigenous;innovation;Intervention;Intervention Studies;Interview;Investments;Knowledge;Lived experience;medical specialties;member;Methods;National Institute of Drug Abuse;Parents;Pharmacotherapy;Prevalence;Public Health;Qualitative Research;Race;Research;Research Personnel;resilience factor;Resources;Structural Racism;substance use;Substance Use Disorder;Testing;therapy development;Trauma;Veterans;Vulnerable Populations;Work

PROJECT_TITLE: Substance Use and Treatment Among American Indian/Alaska Native Veterans: Foundation Building for a Comprehensive Community-Partnered Type I Hybrid Intervention Study


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Congenital Structural Anomalies;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Nemaline myopathy (NM) causes skeletal muscle weakness primarily presenting at birth or early childhood. NM diagnosis, clinical treatment and basic science research typically focuses on the muscle breakdown component of the disease without considering the inputs needed for muscle function. This proposal aims to understand the molecular changes in communication leading to muscle contraction prior to the muscle breakdown seen in NM.

PI_NAMEs: CHRISTOPHERS, BRIANA  (contact)

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: Actin-Binding Protein;Actins;Action Potentials;Address;Affect;Basic Science;Binding;Biochemical;Biology;Biopsy;Birth;Calcium;Calcium Signaling;causal variant;Cell Maintenance;Cells;Characteristics;Childhood;Clinical;Clinical Treatment;cofilin;cofilin 2;Communication;Complement;confocal imaging;Coupling;Cytoplasm;Data;Defect;Deterioration;Development;Diagnosis;differential expression;Disease;Drosophila genus;Drosophila melanogaster;early childhood;Electromyography;Electrons;Electrophysiology (science);Event;Exercise;exercise intensity;exercise regimen;experimental study;fluorescence imaging;Functional disorder;Genes;genetic manipulation;Growth;Histopathology;Human;human disease;Image Analysis;Imaging Techniques;Incidence;innovation;insight;interest;Ions;knock-down;Knockout Mice;Larva;Life;Link;Literature;Live Birth;Mechanics;Membrane;Membrane Potentials;Microfilaments;Microscopy;Modeling;Molecular;morphological criteria;Morphology;Motor Neurons;Mus;Muscle;Muscle Cells;Muscle Contraction;Muscle function;Muscle hypotonia;Muscle Weakness;Muscular Atrophy;Myopathy;Myosin ATPase;Nemaline Myopathies;Neuromuscular Junction;neuronal patterning;Neurons;Neurotransmitter Receptor;neurotransmitter release;novel therapeutics;Organism;Output;Pathology;Patients;Pattern;Pediatrics;perinatal period;Phenotype;Physicians;Play;postnatal;postsynaptic;Preparation;Process;Protein Isoforms;Proteins;receptor;Regulation;Research;Research Personnel;response;Rod;Role;Sampling;Sarcomeres;Sarcoplasmic Reticulum;Scientist;Side;Signal Transduction;Skeletal Muscle;skeletal muscle weakness;Structure;Synapses;System;Technical Expertise;Techniques;Testing;Training;transcriptome sequencing;ultra high resolution;Work

PROJECT_TITLE: The contributions of excitation and contraction to muscle deterioration in a Drosophila model of CFL2 nemaline myopathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Social Determinants of Health

PHR: PROJECT NARRATIVE Most mental health disorders arise during adolescence, with depression being one of the most consequential given its long-term effects well into adulthood. The proposed study aims to determine if a child’s genetics and their family socioeconomic status interact to shape longitudinal changes in emotional brain and behavior development that could ultimately increase their risk of depression using a large, diverse nationwide sample of U.S. youth between the ages of 9 to 12 years. Ultimately understanding how these two concepts interact will help policy makers, clinicians, and scientists better detect, alleviate, and treat the burden of depression for individuals and communities.

PI_NAMEs: CAMPBELL, CLAIRE EDWARDS (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: 10 year old;12 year old;Address;Adolescence;Adolescent;Adult;Affect;Age;Age Years;Amygdaloid structure;Area;Behavior;Behavioral;behavioral outcome;Biological Markers;Brain;brain behavior;brain circuitry;Brain imaging;brain size;burden of illness;Child;child depression;Childhood;Classification;Cognitive;cognitive control;cognitive development;Communities;Complex;Data;depressive symptoms;Development;Disease;early adolescence;early detection biomarkers;Early Diagnosis;Early Intervention;early onset;Early treatment;Emotional;emotional behavior;Environment;Environmental Exposure;Environmental Risk Factor;Family;federal poverty level;follow-up;Foundations;Functional Magnetic Resonance Imaging;gene environment interaction;Genes;Genetic;Genetic Risk;Goals;Grant;Health;Hippocampus;Household;improved;Income;Individual;Individual Differences;Influentials;intervention program;Investigation;Life;Long-Term Effects;Low income;Maps;Measures;Mediating;Mental Depression;Mental disorders;Methodology;Modeling;morphometry;MRI Scans;neural;neurodevelopment;neuroimaging;Onset of illness;Outcome;Persons;Policy Maker;polygenic risk score;Population;Poverty;Publishing;Recurrence;recurrent depression;Research;Research Personnel;Rest;Risk;Risk Factors;Sampling;Scientist;Severities;Shapes;single episode major depressive disorder;Site;skills;social health determinants;Socioeconomic Status;Structure;Surface;Symptoms;Testing;Thick;Time;Training;treatment program;United States;Withdrawal Symptom;Work;World Health Organization;young adult;Youth

PROJECT_TITLE: Independent and interactive effects of genetic risk for depression and family income-to-needs on emotional brain development and behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-L(20)L]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative It is thought that homologous recombination (HR) and fork protection (FP) deficiencies produce points of vulnerability in cancer cells that sensitize them to DNA damaging agents such as to cisplatin and Poly (ADP- ribose) polymerase (PARP) inhibitors (PARPi), but our recent findings indicate that single stranded DNA (ssDNA) gaps are the killing lesion such that gap suppression (GS) deficiencies could sensitize cancer cells to therapies. BRCA2 is required for GS thus by studying therapy response in the model system of BRCA-deficient cancer, in which distinct mechanisms via separation-of-function models have been linked to resistance, we will have the opportunity to determine if instead resistance is also or solely mediated by GS, a question that has yet to be addressed. This goal of this study is to systematically disrupt and retain each function (HR, FP, GS) within BRCA2 to define what function is critical for therapy resistance, elucidate a unified mechanism of resistance, and provide insight into inhibiting pathways of resistance to inform therapeutic choices.

PI_NAMEs: WHALEN, JENNA  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Acceleration;Address;anti-cancer;Apoptosis;Apoptosis Inhibitor;Binding Sites;Biological Assay;Biological Models;BRCA deficient;brca gene;BRCA1 gene;BRCA2 gene;Breast Cancer gene;cancer cell;Cell Death;cell killing;Cell model;Cell Survival;Cells;Chemoresistance;chemotherapy;Cisplatin;Clinical;Clone Cells;CRISPR/Cas technology;Defect;Development;DNA;DNA Binding;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA fiber assay;DNA Repair;DNA replication fork;Dose;effective therapy;experimental study;Fiber;Future;Genes;Goals;Hereditary Breast and Ovarian Cancer Syndrome;Hereditary Breast Carcinoma;homologous recombination;Immunofluorescence Immunologic;Induction of Apoptosis;Inhibition of Apoptosis;insight;Knowledge;Lesion;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;Measures;Mediating;Mediator;Modeling;Molecular;Mutagens;mutant;Mutate;Mutation;Pathway interactions;Patients;Pharmaceutical Preparations;Play;Point Mutation;Poly(ADP-ribose) Polymerase Inhibitor;Prediction of Response to Therapy;Predisposition;prevent;Proteins;Regulation;Research;Resistance;Resistance development;resistance mechanism;response;restraint;Role;Sampling;Series;Single-Stranded DNA;Stress;Testing;Therapeutic;Therapeutic Intervention;Time;tissue culture;treatment response;tumor;Tumor Markers

PROJECT_TITLE: Mapping the BRCA2 replication gap suppression domain to uncover themolecular mechanism of chemotherapy response


ADMINISTERING_IC: CK

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: National Center for Emerging and Zoonotic Infectious Diseases

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Healthcare-associated infections (HAI) and antibiotic-resistance (AR) increase patient morbidity and mortality. The proposed work will lead to new strategies for preventing HAI, AR and other adverse events in all types of healthcare facilities in the United States.

PI_NAMEs: HARRIS, ANTHONY D (contact)

PROJECT_TITLE: RFA-CK20-004: Prevention Epicenters Program: Protecting Patients from Infections, Antibiotic Resistance andOther Adverse Events


ORG_CITY: IOWA CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE This proposal is important for public health because it will allow us to prevent spread of infections by improving the equipment healthcare providers wear, and by reducing environmental contamination. This proposal will also enable us to: 1) expand surveillance by harnessing a novel cell phone technology to identify infections acquired in hospitals that become symptomatic after patients are discharged and 2) identify both patients at high risk of becoming septic while hospitalized and factors we could modify to prevent this serious complication. Moreover, the proposal will enable us to decrease the risk of antibiotic resistance and the incidence of antibiotic side effects by improving antibiotic prescribing overall, in urgent care clinics, and at the time of hospital discharge.

PI_NAMEs: HERWALDT, LOREEN A (contact)

PROJECT_TITLE: RFA-CK20-004: Infection Prevention and Antimicrobial Stewardship: Minding the Gaps: The Iowa Prevention Epicenter


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Neurosciences;Urologic Diseases

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: DIGNIFY THERAPEUTICS, LLC

PHR: PROJECT NARRATIVE The ultimate aim of this project is to develop a novel pharmaceutical treatment that will produce efficient and safe on-demand voiding in people with bowel and bladder retention disorders due to spinal cord injury and diseases such as multiple sclerosis, diabetes, and complications of aging. Many people with these disorders rely on daily digital bowel programs and multiple daily bladder catheterizations as surrogates for voluntary defecation and urination. This grant will fund the completion of FDA-mandated nonclinical studies that will enable submission of an Investigational New Drug Application for future clinical studies.

PI_NAMEs: BURGARD, EDWARD  (contact)

PROGRAM_OFFICER_NAME: ARUDCHANDRAN, RAMACHANDRAN NMN

PROJECT_TERMS: Acute;Aging;Agonist;analytical method;Award;Biological Assay;Bladder;Cardiovascular system;Catheterization;Central Nervous System;Clinical;clinical development;Clinical Research;Colon;Colorectal;Cytochrome P450;Defecation;Diabetes Mellitus;digital;Disease;Dose;Drug Interactions;Drug Kinetics;Drug Targeting;Electronics;Electrophysiology (science);Enzymes;Ethers;Fecal Incontinence;Funding;Future;Genes;Genetic;good laboratory practice;Good Manufacturing Process;Grant;Guidelines;healthy volunteer;Human;human tissue;In Vitro;in vivo;Incontinence;Intestines;Intramuscular;Intramuscular Injections;Intravenous;Investigational New Drug Application;Macaca fascicularis;manufacture;manufacturing test;Measurement;Measures;Mediating;meetings;micronucleus;Miniature Swine;Monitor;Multiple Sclerosis;Mutation;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;nonhuman primate;novel;novel therapeutics;Parkinson Disease;Pathway interactions;patient population;Patients;Peptide Receptor;Persons;Pharmaceutical Preparations;Pharmacodynamics;Pharmacologic Substance;Phase;phase 2 study;Plasma;pre-clinical;preclinical development;preclinical efficacy;preclinical study;Preparation;pressure;programs;Rattus;Recommendation;Recovery;Regulation;respiratory;Route;Safety;safety assessment;safety practice;safety study;Sampling;Site;Smooth Muscle;Spinal cord injury;Spinal Dysraphism;stability testing;Sterility;Stroke;subcutaneous;Substance K Receptor;Therapeutic;Toxic effect;Toxicokinetics;Toxicology;Urinary Incontinence;Urinary Retention;Urination;Validation

PROJECT_TITLE: Preclinical and Early Clinical Development of a Novel Drug for On-Demand Voiding

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Genetics;Human Genome;Multiple Sclerosis;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: LA JOLLA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Oxidative stress is a common pathological thread in many neuroinflammatory and neurodegenerative diseases, including multiple sclerosis (MS). To date, there are no treatments for the prevention of neurodegeneration caused by innate immune-mediated oxidative injury in MS. The goal of this project is to determine the epigenomic mechanisms underlying oxidative stress gene activity and function in toxic innate immune cells in MS models, which may provide therapeutic candidates for intervention of MS.

PI_NAMEs: MENDIOLA, ANDREW S (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Advisory Committees;ATAC-seq;Binding;biological adaptation to stress;Biological Assay;brain control;brain tissue;California;Candidate Disease Gene;candidate identification;career;career development;cell type;Cells;Central Nervous System;Chromatin;chromatin immunoprecipitation;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Communities;Complex;Coupled;CRISPR interference;Data;Data Set;Dedications;derepression;Development;Disease;Disease Progression;Elements;Enhancers;Environment;Epigenetic Process;epigenome;epigenomics;Experimental Autoimmune Encephalomyelitis;Experimental Designs;Faculty;Failure;Fluorescent in Situ Hybridization;Future;Gene Expression Profile;gene repression;Gene Targeting;Genes;genetic signature;Genetic Transcription;Genome engineering;genomic locus;Genomics;Goals;histone modification;Histones;Immune;immune function;Immune response;Immune System Diseases;Immunohistochemistry;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;Innate Immune Response;Innate Immune System;innovation;Intervention;Investigation;Investments;Laboratories;Laboratory Research;Leadership;Link;loss of function;Macrophage;Macrophage Activation;Maps;Mediating;Mentors;Methods;Microglia;Modeling;Molecular;mouse model;Multiple Sclerosis;multiple sclerosis treatment;Mus;NADPH Oxidase;Natural Immunity;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neuroinflammation;Neurons;neuroprotection;neurotoxic;neurovascular;novel;novel therapeutic intervention;novel therapeutics;Nucleic Acid Regulatory Sequences;Outcomes Research;oxidative damage;Oxidative Regulation;Oxidative Stress;Oxidative Stress Induction;Pathogenesis;Pathogenicity;Pathologic;Peripheral;Pharmaceutical Preparations;Phase;Phenotype;prevent;Prevention;Process;Production;programs;promoter;Reactive Oxygen Species;Regulatory Element;Relapse;Reporter;Repression;Research;Resources;RNA;Role;San Francisco;Signal Pathway;single molecule;Spinal Cord;Testing;Therapeutic;therapeutic candidate;therapeutic target;Training;transcription factor;Translating;Universities

PROJECT_TITLE: Epigenomic regulation of oxidative stress-producing innate immunity in neuroinflammation


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Epilepsy;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: PROJECT NARRATIVE Fundamental abilities, such as keeping track of where we are, or forming episodic memories during social experiences, critically depend on the continuous processing and encoding of spatial information about the self, others, and the environment. Impairments in these abilities are among the hallmark symptoms of Alzheimer’s and other neurological diseases. The proposed research therefore aims to enhance our understanding of the neural mechanisms that underlie the encoding of spatial information and awareness of others, which will ultimately help elucidate the neurophysiological origins of malfunctions in these systems.

PI_NAMEs: STANGL, MATTHIAS  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TITLE: Neural Mechanisms of Spatial Representations Beyond the Self


ORG_CITY: RICHARDSON

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: Project Narrative Respiratory syncytial virus (RSV) is among the leading cause of pediatric death secondary to pneumonia worldwide and requires rapid and sensitivity diagnostics. We propose a novel, rapid, sensitive method for RSV diagnostics by digital nanobubble detection in a gold nanoparticle-based diagnostic assay. Success of this project will address a significant problem that affects infants and children in the US and worldwide.

PI_NAMEs: QIN, ZHENPENG  (contact)

PROGRAM_OFFICER_NAME: KIM, SONNIE

PROJECT_TERMS: absorption;Address;Affect;analog;Anti-viral Therapy;Antibiotics;Antibodies;antibody conjugate;Area;Bar Codes;Binding;Biological Assay;Biosensing Techniques;Biosensor;Bypass;Cell Culture Techniques;Cessation of life;Child;Childhood;Chimeric Proteins;Clinical;Clinical Sensitivity;clinical translation;Color;Communicable Diseases;computerized data processing;Consumption;cost;Coupled;Coupling;Darkness;Data;design;Detection;detection limit;Development;Device or Instrument Development;Devices;Diagnosis;Diagnostic;diagnostic assay;Diagnostic Equipment;Diagnostic Procedure;Diagnostic Sensitivity;Diagnostic tests;digital;digital data;Disease;Evaluation;Formulation;Future;Generations;genetic strain;Health care facility;Healthcare;Immunoassay;improved;Infant;innovation;Interdisciplinary Study;isothermal amplification;Laboratories;Lasers;Lateral;lateral flow assay;Lead;Measures;Membrane Proteins;Methods;Microspheres;nanobubble;nanoGold;nanoparticle;nanorod;nanoscale;Nanosphere;novel;Nucleic Acids;operation;Optics;Outcome;pediatric patients;Performance;performance tests;Physiologic pulse;plasmonics;Pneumonia;point-of-care diagnostics;Polymerase Chain Reaction;Preparation;Process;Proteins;prototype;Quantum Dots;Rapid diagnostics;Reading;Reagent;research clinical testing;respiratory pathogen;Respiratory syncytial virus;response;Rod;Sampling;Secondary to;Sensitivity and Specificity;sensor;Signal Transduction;solid state;Specificity;Specimen;Speed;success;superinfection;Surface;System;Testing;Time;Training;Vaccines;viral detection;Virion;Virus;virus culture;Work

PROJECT_TITLE: Rapid Diagnostic Test for Respiratory Syncytial Virus by Digital Nanobubbles

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunization;Immunotherapy;Infectious Diseases;Prevention;Vaccine Related

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative A properly functioning cellular immune response is essential to the eradication of infectious diseases and cancer, whereas inappropriate cellular immune regulation results in debilitating autoimmune conditions. Given that cellular immunity plays such a critical role in the disease process, a better understanding of the innate regulatory mechanisms governing cellular immunity would allow for the formulation of novel vaccine and pharmaceutical interventions that would enormously benefit human health and well-being. Completion of the work outlined herein will permit the immunoregulatory role of a critical basic factor, the novel gene product AIMp1, to become fully elucidated thereby enabling a) simpler production of more effective and less-expensive vaccines and b) the characterization of new druggable target interactions that will form the basis of the next generation of pharmaceuticals for the treatment of cancer, infectious disease, and autoimmune conditions.

PI_NAMEs: DECKER, WILLIAM KARL (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Ablation;adaptive immune response;Adoptive Transfer;Alleles;Animals;anti-tumor immune response;Antitumor Response;arm;Attenuated Vaccines;Autoimmune Diseases;Back;Binding;Bioinformatics;Biological;Blocking Antibodies;Bone Marrow;cancer therapy;Cell Physiology;cell type;Cells;Cellular Immunity;Circulation;Clinical;Communicable Diseases;Complex;Cues;cytokine;Data;Data Set;Dedications;Defect;Dendritic Cells;Detection;Diagnosis;Disease;Drug Design;druggable target;DUSP1 gene;Effector Cell;Elements;Exhibits;Formulation;FOS gene;Functional disorder;Gene Expression Profiling;Gene Expression Regulation;gene product;Generations;Genetic;genetic signature;Genomics;Health;Helper-Inducer T-Lymphocyte;Heterodimerization;Human;human disease;IL12A gene;Immune;immune function;Immune response;Immune signaling;Immune system;Immunity;Immunocompromised Host;immunoregulation;In Vitro;in vivo;Individual;Infection;Influenza;influenza infection;Interferon Type II;Interleukin-12;interleukin-12 receptor;Intervention;ITGAM gene;Knockout Mice;Lung;lymph nodes;Maintenance;Malignant Neoplasms;MAP Kinase Gene;Mediating;mouse model;Mus;Myelogenous;Natural Immunity;new therapeutic target;next generation;novel;novel vaccines;p38 Mitogen Activated Protein Kinase;pathogen;Pathway interactions;Patients;Peripheral;Personal Satisfaction;pharmacologic;Pharmacologic Substance;Phase;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Physiological;Play;polarized cell;Population;Primary Neoplasm;Process;Production;Prophylactic treatment;Protein Array;Protein Phosphatase 2A Regulatory Subunit PR53;Proteins;Recombinant Proteins;response;Role;Sampling;Signal Induction;Signal Transduction;Specificity;Spleen;T cell response;T memory cell;T-Lymphocyte;T-Lymphocyte Subsets;Testing;The Cancer Genome Atlas;Tissues;Transcription Factor AP-1;transcriptome sequencing;tumor;Tumor Antigens;Tumor Immunity;Up-Regulation;Vaccination;vaccination strategy;Vaccines;Viral;Virus;Virus Diseases;Work

PROJECT_TITLE: Innate DC Govern TH Polarization through the Novel Regulator AIMp1

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-S(02)M]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Depression;Estrogen;Mental Health;Mental Illness;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

PHR: Mild traumatic brain injury affects adolescent girls participating in contact sports to a greater extent than boys. Moreover, these girls suffer long term behavioral problems typically not seen in their male counterparts. By understanding the sex-dependent mechanisms underlying these behavioral problems, a targeted treatment strategy may be developed.

PI_NAMEs: RAGHUPATHI, RAMESH  (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: adeno-associated viral vector;Adolescence;Adolescent;Adult;Affect;Age;Agonist;Anhedonia;Animal Testing;Animals;antagonist;Anxiety;axon injury;Behavior;Behavioral;boys;Brain Concussion;Brain Injuries;Chronic;Cognitive deficits;college;contact sports;Data;depressive behavior;depressive symptoms;design;designer receptors exclusively activated by designer drugs;Development;Diagnosis;Dopamine;Dopamine D2 Receptor;dopaminergic neuron;Emergency department visit;Emotional Disturbance;ESR1 gene;Estrogen Receptor 2;Estrogen Receptors;Estrogens;Estrous Cycle;Estrus;Executive Dysfunction;Exhibits;experience;experimental study;extracellular;Female;Female Adolescents;forced swim test;Genetic;genetic approach;girls;Headache;high school;Hormone Receptor;Hormones;Immobilization;injured;Injury;male;Male Adolescents;Measures;Medial;Mediating;Mediator;Medical;Membrane;Mental Depression;Microdialysis;mild traumatic brain injury;Modeling;Mood Disorders;Mus;Neurons;Patients;Persons;pharmacologic;Phase;Phenols;Phenotype;Phosphorylation;postsynaptic;preclinical study;preference;Prefrontal Cortex;premenstrual dysphoric disorder;Problem behavior;Proestrus;Progesterone Receptors;promoter;Protein Dephosphorylation;Protein Isoforms;Proteins;Quinpirole;Rattus;Receptor Activation;receptor binding;receptor expression;Reporting;resilience;Risk;RNA Splicing;Selective Estrogen Receptor Modulators;sex;Signal Transduction;Sports;Substance abuse problem;Substance Use Disorder;Sucrose;Surface;Symptoms;Tamoxifen;targeted treatment;TBI Patients;Testing;Traumatic Brain Injury;treatment strategy;Tyrosine 3-Monooxygenase;United States;vector;Ventral Tegmental Area;Virus;Woman;young adult

PROJECT_TITLE: Dopaminergic Mechanisms Underlying Behavioral Deficits Following Mild TBI

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: College Station

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

PHR: Project Narrative  Bacteriophages, the viruses of bacteria, are now emerging as important alternatives to antibiotics, as the era of multi-drug resistant bacterial infection is beginning. This proposal seeks to deepen our understanding of how phages accomplish the destruction of the bacterial cell. In addition, by studying the ways in which phages can attack the bacterial cell wall, fundamental new clues to the design of new antibiotics are likely to emerge.

PI_NAMEs: YOUNG, RYLAND FLETCHER (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TITLE: Phage Lysis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PI_NAMEs: KANNEGANTI, THIRUMALA-DEVI  (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: Apoptosis;Applications Grants;Area;Aspergillus fumigatus;Automobile Driving;Biochemical;CASP1 gene;Caspase;Cell Death;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;computerized tools;cytokine;Cytoplasm;experimental study;Family;Funding;galactosaminogalactan;Genes;Genetic;genetic approach;Genome;Host Defense;Human;IL18 gene;Immune;Immune response;Immune signaling;Immunity;Immunocompromised Host;Immunology;Immunoprecipitation;in vivo;Individual;Infection;Inflammasome;Inflammation;Inflammatory;Influenza A virus;Interleukin-1 beta;Knockout Mice;Laboratories;Mass Spectrum Analysis;Mediating;member;Microbiology;Modeling;Molecular;Morbidity - disease rate;mortality;Mouse Strains;Multiprotein Complexes;Mycoses;Natural Immunity;Nature;next generation sequencing;novel;Paper;pathogen;pathogenic fungus;Pathway interactions;Pattern recognition receptor;Peer Review;Play;Positioning Attribute;Proteomics;Publications;receptor;Research;response;Role;scaffold;screening;sensor;Signal Pathway;Signal Transduction;System;targeted treatment;Techniques;Testing;Therapeutic Intervention;Toll-like receptors;tool;whole genome;Z-DNA Binding Protein

PROJECT_TITLE: Inflammatory Caspases in Innate Immunity and Inflammation


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Immunization;Prevention;Regenerative Medicine;Vaccine Related;Women's Health Research;Wound Healing and Care

ORG_CITY: BALTIMORE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative  The foreign body reaction (FBR) to material implants was first described in the 1970s yet continues to induce implant rejection. With the proportion of people over 60 years old doubling from 12% to 22% by 2050 there is a critical need to better understand how chronic inflammation alters the FBR which will enable biomedical engineers to improve implant design. The overarching goals of this proposed work is to identify key biologic factors to target to develop immunomodulatory synthetic materials for use in the aging population for tissue regeneration.

PI_NAMEs: MEJIAS, JOSCELYN CLARALUZ (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Adaptive Immune System;Address;Adverse reactions;Age;age difference;age related;age-related disease;aged;Aging;aging population;Automobile Driving;Award;Biocompatible Materials;bioinformatics tool;Biological;Biological Factors;biomaterial compatibility;Biomedical Engineering;career;Cell Communication;cell type;Cells;Chronic;Cicatrix;Communication;Compensation;design;Development;Devices;Drug Delivery Systems;Engineering;experimental study;Female;Fibrosis;first responder;Flow Cytometry;Foreign-Body Reaction;Functional disorder;Goals;hallmarks of aging;healing;Health;Histology;Human;Hydrogels;Immune;immune function;Immune response;Immune system;Immune Targeting;immunoengineering;Immunofluorescence Immunologic;Immunologics;immunoregulation;Implant;implant design;implant material;improved;Infection;Inflammation;Inflammatory;inflammatory marker;Injury;Innate Immune System;Institution;life span;Location;Macrophage;Maintenance;male;Modeling;mouse model;Mus;Natural regeneration;neutrophil;non-healing wounds;old mice;Outcome;particle;Patients;Persons;Phase;Phenotype;polycaprolactone;Population;Positioning Attribute;Predisposition;prevent;Prosthesis;regenerative;Regenerative capacity;Regenerative engineering;Reporting;Research;Research Personnel;response;response to injury;Reverse Transcriptase Polymerase Chain Reaction;scaffold;senescence;senescent cell;sex;Sex Differences;single-cell RNA sequencing;Site;Splenocyte;Stromal Cells;System;T-Lymphocyte;Techniques;Testing;Therapeutic;therapeutic target;Tissue Engineering;tissue regeneration;tissue repair;Tissues;training opportunity;tumor-immune system interactions;Vaccines;Work;wound healing

PROJECT_TITLE: Age and sex differences in the immune response to synthetic materials


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Heart Disease;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

PHR: PROJECT NARRATIVE Exercise is one of few treatments shown to benefit adults with heart failure with preserved ejection fraction (HFpEF). Yet, exercise is one of the most challenging treatments for adults with HFpEF to start and continue over time. This study tests two behavioral interventions, Heart Failure Exercise and Resistance Training (HEART) Camp (in-person) and HEART Camp Connect (virtual), designed to promote adherence to exercise and improve physical function, inflammation, symptoms, and quality of life.

PI_NAMEs: ALONSO, WINDY WILLIAMS (contact)

PROGRAM_OFFICER_NAME: SHIROMA, ERIC JITSUO

PROJECT_TERMS: Adherence;Adult;Algorithms;Area;Attitude;behavior change;Behavior Therapy;Behavioral Mechanisms;Benchmarking;Biological Assay;Biological Markers;Cardiovascular system;Caring;Clinical;clinical care;compliance behavior;Congestive Heart Failure;Cost Analysis;cost effective;cost-effectiveness ratio;Costs and Benefits;Data;design;Direct Costs;efficacy testing;EFRAC;Evaluation;Event;Exercise;exercise adherence;exercise intensity;exercise intervention;exercise intolerance;Exercise Test;exercise training;experience;Facilities and Administrative Costs;Future;Goals;Guidelines;Health Status;Heart failure;Heart Rate;Hospitalization;improved;incremental cost-effectiveness;Inflammation;Inflammatory;Informal Social Control;Injury;innovation;Intervention;intervention cost;intervention delivery;Intervention Trial;Measures;Mediating;Mediation;Mediator;Medicine;mortality;National Heart, Lung, and Blood Institute;Outcome;Participant;Patient Outcomes Assessments;Patients;Perception;Persons;pharmacologic;Physical activity;Physical Function;Physiological;preservation;primary outcome;Quality of life;Randomized, Controlled Trials;Recommendation;resistance exercise;Science;secondary analysis;Self Efficacy;Subgroup;Symptom Burden;Symptoms;Testing;Theoretical Studies;theories;therapy design;Time;Training;treatment as usual;Treatment Efficacy;virtual;virtual coach;virtual delivery;web app;Work;working group

PROJECT_TITLE: HEART Camp Connect: Promoting Adherence to Exercise in Adults with Heart Failure with Preserved Ejection Fraction

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homelessness;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Transgender women of color experience systemic racism and transphobia, which contributes economic vulnerability and HIV inequities. The proposed R34 application seeks to adapt and evaluate the feasibility and acceptability of a microeconomic intervention designed with and for transgender women of color to improve HIV prevention and care continua outcomes. The proposed approach will provide the necessary groundwork for an efficacy trial in a future, large-scale randomized controlled trial.

PI_NAMEs: GAMAREL, KRISTI E (contact);JENNINGS MAYO-WILSON, LARISSA

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;aged;AIDS prevention;antiretroviral therapy;Area;arm;Benchmarking;Black race;Black, Indigenous, People of Color;Businesses;care outcomes;Caring;cisgender;Color;Communities;community advisory board;community partners;community-centered;comparison intervention;Consultations;Continuity of Patient Care;Data;Data Collection;Economics;Education;efficacy trial;Emergency Situation;Employment;empowerment;Ensure;Entrepreneurship;Epidemic;epidemic preparedness;ethnic disparity;experience;financial literacy;follow-up;food insecurity;Funding;Future;Gender;gender affirmation;gender minority community;Generations;Goals;Grant;Health Disparities Research;Health Personnel;HIV;HIV disparities;HIV risk;Homelessness;Housing;housing instability;Human immunodeficiency virus test;implementation process;improved;Incidence;Income;Indigenous;Inequity;information gathering;Institution;Institutional Racism;Intervention;intervention refinement;Interview;Latina;Legal;Manuals;Measures;Mentors;Michigan;Modeling;Names;Occupations;Outcome;Participant;peer;Persons;Phase;pilot test;post intervention;Poverty;pre-exposure prophylaxis;Prevalence;programs;Public Health;public health relevance;Race;racism;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research;Resources;Respondent;response;retention rate;Sexual and Gender Minorities;social media;social structure;structural determinants;Surveys;System;therapy design;Training;transgender women;transphobia;treatment as usual;Treatment Efficacy;United States;United States National Institutes of Health;uptake;Viral;women of color;Work

PROJECT_TITLE: Strengthening community responses to economic vulnerability and HIV inequities

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Preterm birth occurs at unacceptably high rates in the United States, with Black women disproportionately affected. A long-recognized risk factor for preterm birth in this population is the relentless exposure to intersectional stress related to racial and sexual discrimination, poverty, and neighborhood disadvantage that Black women often experience from an early age. In this interdisciplinary study, we bring together experts in preterm birth, music therapy, and metabolomics to address this health disparity by testing the efficacy of a live, culturally based music intervention to reduce the production of metabolites and metabolic pathways associated with chronic stress and thereby improve birth outcomes.

PI_NAMEs: CORWIN, ELIZABETH JEANNE (contact);LOEWY, JOANNE V.

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: 3-Dimensional;37 weeks gestation;Academy;Address;adverse maternal outcomes;Affect;Age;arm;Baseline Surveys;Behavior;Bioinformatics;Biological;Biological Markers;Birth;Black race;black women;Blinded;Chronic stress;Citric Acid Cycle;Clinic;Clinical;Clinical Trials;comparison intervention;Control Groups;Corwin;cytokine;Demographic Survey;Discipline of obstetrics;Discrimination;Disparity;Disproportionately impacts women;distraction;early experience;efficacy testing;Elements;experience;Exposure to;First Pregnancy Trimester;follow-up;food insecurity;Fundulus heteroclitus;Gestational Age;Glucocorticoids;Goals;group intervention;Health;Health Disparities Research;health disparity;health disparity populations;high risk;Household;Human;Hydrocortisone;improved;improved outcome;Individual;Infant;infant outcome;Inflammatory;innovation;Institute of Medicine (U.S.);Interdisciplinary Study;Intervention;intervention effect;Life Cycle Stages;Link;low socioeconomic status;Mass Spectrum Analysis;maternal stress;Measures;Mediating;Medicine;Metabolic;Metabolic Pathway;metabolic profile;metabolomics;Music;Music Therapy;myelination;National Institute on Minority Health and Health Disparities;neighborhood disadvantage;Neighborhoods;Newborn Infant;novel;Outcome;Oxidative Stress;Participant;Pathway Analysis;Patient Self-Report;perceived stress;Plasma;Population;Populations at Risk;Poverty;Pregnancy;Pregnancy Trimesters;pregnant;Pregnant Women;Premature Birth;prenatal;Production;Race;racial disparity;Randomized;Recording of previous events;recruit;Reporting;Research;Research Personnel;Resistance;Resolution;Risk;Risk Factors;saliva sample;Salivary;Sampling;Second Pregnancy Trimester;sex;social health determinants;Socioeconomic Status;stem;Stress;stress reduction;stressor;Surveys;System;Technology;Testing;Therapeutic;Therapeutic Intervention;Time;tool;United States;verbal;White Women;Woman;women's outcomes

PROJECT_TITLE: The impact of a culturally-based live music intervention on the metabolites and metabolic pathways associated with chronic stress and the risk of preterm birth in Black women


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSURGERY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Meningiomas are the most common brain tumor and are usually benign, but because they cause neurological deficits by compressing brain structures, they are treated surgically or with radiation. The proposed research is relevant to public health because understanding the genomic architecture of meningiomas will provide the necessary background to test the response of these tumors to targeted drugs.

PI_NAMEs: GUNEL, MURAT  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Acute;adenoma;Adult;Anaplastic Meningioma;Animal Model;Architecture;Automobile Driving;Benign;Benign Meningiomas;Biochemical;Biological Assay;Blood - brain barrier anatomy;Brain;Brain Neoplasms;candidate validation;Cell Line;Cell Proliferation;Cells;ChIP-seq;Clinical Trials;Code;Collection;Deubiquitinating Enzyme;DNA Methylation;driver mutation;drug efficacy;Drug Targeting;Effectiveness;efficacy testing;epigenomics;Event;Excess Mortality;exome;exome sequencing;Future;Genes;Genitalia;Genomic approach;genomic profiles;Genomics;Glioblastoma;Glioma;Hand;Histologic;Histology;Human;Incidence;inhibitor;insight;Intracranial Neoplasms;Intraneural perineurioma;Invaded;Malignant - descriptor;Meningeal;meningioma;Mesothelioma;Molecular;Morbidity - disease rate;mouse model;mutant;Mutate;Mutation;Neurofibromin 2;Neurologic;Neurologic Deficit;neurovascular;new therapeutic target;next generation sequencing;NF-kappa B;novel therapeutics;Oncogenic;Operative Surgical Procedures;Pathway interactions;Patients;Pharmaceutical Preparations;PIK3CG gene;Population;Primary Brain Neoplasms;Principal Investigator;programs;protein function;Public Health;Radiation;Recurrence;Recurrent tumor;Reporting;Research;Resected;response;Role;Signal Pathway;Signaling Molecule;skull base;Stroke;Structure;subcutaneous;Subgroup;Testing;Therapeutic;transcriptome sequencing;tumor;ubiquitin isopeptidase;ubiquitin ligase;ubiquitin-protein ligase;United States;Untranslated RNA;whole genome

PROJECT_TITLE: Molecular Mechanisms of TRAF7 Mutant Aggressive Meningiomas

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: AUSTIN

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE Uncontrolled asthma in school-aged children is a significant public health problem. Low-SES Latino children are at increased risk for uncontrolled asthma compared to non-Latino white children, and psychosocial stress is an unaddressed factor in this disparity. Therefore, the proposed intervention targets coping with stress as a way to reduce risk for uncontrolled asthma in low-SES Latino children.

PI_NAMEs: RODRIGUEZ, ERIN M. (contact)

PROGRAM_OFFICER_NAME: HERREN, OLGA MARINA

PROJECT_TERMS: 13 year old;2 arm randomized control trial;acceptability and feasibility;Address;Affect;Age;arm;Asthma;asthma exacerbation;Behavior;Belief;bilingualism;Buffers;Child;Childhood Asthma;clinical decision-making;Cognitive;Communities;compare effectiveness;Control Groups;coping;Coping Skills;cost;cost effective;depressive symptoms;Disparity;disparity reduction;Education;Educational Curriculum;effective therapy;Effectiveness;effectiveness testing;Elements;Emergency department visit;Empirical Research;Enrollment;evidence base;experience;Family;Financial Hardship;follow-up;functional outcomes;Goals;Health;health disparity;Hospitalization;Household;Immigration;implementation trial;improved;insight;Intervention;Knowledge;Latino;Link;low socioeconomic status;Mediating;Mediator;Moods;Outcome;Parents;Pathway interactions;Patients;Pharmaceutical Preparations;Pilot Projects;Population;Populations at Risk;post intervention;Poverty;Primary Care;primary care clinic;Problem behavior;Process;programs;psychobiologic;psychosocial;Psychosocial Stress;Public Health;pulmonary function;Quality of life;Randomized;Records;recruit;Reporting;Research;Risk;Risk Reduction;Role;Sampling;School-Age Population;Schools;Self Management;Site;social health determinants;Societies;Spanish;Spirometry;Stress;Stress and Coping;stressor;Symptoms;Testing;translational research program;Underserved Population;Work;Youth

PROJECT_TITLE: A Coping Skills Intervention for Low-SES Latino Families of Children with Asthma

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: This proposal will explore the human stem cell model previously generated by our group for spinal and bulbar muscular atrophy (SBMA). This work will elucidate the transcriptional regulation involved in this disease and elucidate how skeletal muscle and motor neurons interact to produce neuromuscular diseases.

PI_NAMEs: MIRANDA, HELEN C (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Adult;Affect;alpha Bungarotoxin;Androgen Receptor;Androgens;Animal Model;AR gene;Atrophic;Biological Assay;cell type;Cells;Central Nervous System;ChIP-seq;chromatin immunoprecipitation;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Consensus;CRISPR interference;Data;Data Set;deep sequencing;defined contribution;Devices;differential expression;Disease;DNA;Electrophysiology (science);Engineering;Etiology;Event;Family;Fertility;Functional disorder;Gene Expression;gene repression;Genes;Genetic;Genetic Transcription;genome-wide;Genomics;Glutamine;Goals;Gynecomastia;Hi-C;Human;human induced pluripotent stem cells;human stem cells;Huntington Disease;In Vitro;induced pluripotent stem cell;Inherited;Kennedy Syndrome;Ligands;Link;Literature;Luciferases;member;Microfluidics;Mitochondria;Molecular;Motor Activity;motor control;motor neuron degeneration;Motor Neuron Disease;Motor Neurons;multi-electrode arrays;Muscle;Muscle Cells;Muscle Contraction;Muscle Weakness;mutant;Mutation;Nervous System Disorder;Neurodegenerative Disorders;neurofilament;Neuromuscular Diseases;Neuromuscular Junction;Neuronal Dysfunction;optogenetics;overexpression;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Phenotype;polyglutamine;promoter;Quantitative Reverse Transcriptase PCR;receptor binding;Research;Resources;Rhodopsin;Skeletal Muscle;spinal and bulbar muscular atrophy;Stanolone;stem cell model;Synapsins;System;theories;Therapeutic;therapy development;tool;transcription factor;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Validation;Work

PROJECT_TITLE: Study of AR transcriptional network in stem cell model of SBMA

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]