ORG_CITY: WORCESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: This proposal will support the Physical Activity Policy Research and Evaluation Network (PAPREN) Coordinating Center at the Prevention Research Center at UMass Chan Medical School, in collaboration with the University of Illinois Chicago and West Virginia University. We seek to establish PAPREN as the leading national research network committed to advancing implementation research designed to increase physical activity using community design interventions through multi-sectoral and community engaged collaborations. We will accomplish this through two major aims: (1) We will conduct an implementation research study to develop an educational strategy that fosters cross-sector collaboration and community engagement that supports that implementation of physical activity supportive community design; and (2) We will grow and support a vibrant, multi-disciplinary and cross-sectoral Network that engages in community design implementation research to support physical activity.

PI_NAMEs: ABILDSO, CHRISTIAAN GERARD;CHRIQUI, JAMIE F;LEMON, STEPHENIE C. (contact)

STUDY_SECTION_NAME: Special Emphasis Panel[ZDP1 OHI (05)]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: NARRATIVE The development of a globally effective HIV-1 vaccine will require the elicitation of broadly neutralizing antibody responses. As such, our proposed studies in this IPCAVD grant are highly relevant to the development of such a vaccine, as we aim to evaluate in humans self-amplifying mRNA vaccines that express two HIV-1 Env-derived protein immunogens that can initiate the maturation of VRC01-class broadly neutralizing antibodies.

PI_NAMEs: STAMATATOS, LEONIDAS  (contact)

PROGRAM_OFFICER_NAME: POOLE, STEVEN THOMAS

PROJECT_TERMS: Acceleration;Adjuvant;Affinity;Animal Model;Antibodies;Antibody Response;Antigens;B-Cell Antigen Receptor;B-Cell Receptor Binding;B-Lymphocytes;Binding;Clinical;Clinical Protocols;Collaborations;Complex;cost;Cyclic GMP;design;Development;env Gene Products;first-in-human;follow-up;Fred Hutchinson Cancer Research Center;Germ Lines;Goals;Grant;Health;HIV Vaccine Trials Network;HIV-1;HIV-1 vaccine;Human;Human immunodeficiency virus test;Immune response;Immunization;Immunize;immunogenic;immunogenicity;improved;Individual;Infection;Infectious Diseases Research;Investigation;Lead;Length;manufacture;Membrane;Messenger RNA;mouse model;Mutate;nanoparticle;neutralizing antibody;Outcome;Participant;Phase;Phase I Clinical Trials;Positioning Attribute;pre-clinical;preclinical evaluation;Production;programs;Property;Proteins;Qualifying;Receptor Gene;Recombinant Proteins;Recombinants;research clinical testing;Research Institute;Research Project Grants;response;RNA vaccine;safety testing;Self-Examination;Somatic Mutation;Surface;Technology;Testing;Vaccination;Vaccines;Virus

PROJECT_TITLE: Self-amplifying mRNA-based vaccines to elicit VRC01-class bnAbs


ADMINISTERING_IC: DP

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_STATE: MA

PHR: We propose to create the ARISe Center for Rural Vaccination at UMass Chan Medical School to contribute to the advancement of immunization services research and develop best practices to promote vaccine confidence. We will use innovative methodologies to first identify characteristics of popular social media fostering vaccine hesitancy and test the effectiveness of vaccine promotion messages in rural populations, then we will use these findings to inform adaptation and testing of a community-led vaccine ambassador campaign. As a collaborating center in the ARISe Network, we will also contribute to network goals and foster new collaborations to support network partners.

PI_NAMEs: LEMON, STEPHENIE C.;RYAN, GRACE W (contact)

PROGRAM_OFFICER_NAME: DARLING, NATALIE

PROJECT_TITLE: ARISe Center for Rural Vaccination at University of Massachusetts Chan Medical School

STUDY_SECTION_NAME: Special Emphasis Panel[ZDP1 OHI (09)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Diabetes;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Up to 42% of women in American Samoa, a medically underserved US territory, develop gestational diabetes (GDM) in pregnancy, making them one of the highest risk groups for GDM and progression to postpartum type 2 diabetes mellitus (T2DM) in the United States. The goal of the proposed project is to investigate how a genetic variant in CREBRF that is common in Pacific Islanders, including American Samoans, influences glucose homeostasis, insulin response, GDM risk and risk of T2DM postpartum. As well as reducing diabetes- related disparities among Pacific Islanders, this work is expected to have a broad and far-reaching impact on the fundamental understanding of diabetes pathogenesis and the potential development of future diabetes therapies for all populations.

PI_NAMEs: BENGTSON, ANGELA ;HAWLEY, NICOLA  (contact);KERSHAW, ERIN E.

PROGRAM_OFFICER_NAME: LAWRENCE, JEAN M

PROJECT_TERMS: adverse birth outcomes;Affect;Alleles;American;American Samoa;Beta Cell;Biometry;Birth;blood glucose regulation;Body Composition;Body mass index;Cell Physiology;Child;clinical practice;Communities;Continuous Glucose Monitor;Data;Dedications;Development;Diabetes Mellitus;diabetes mellitus therapy;diabetes pathogenesis;Diabetes prevention;diabetes risk;Diagnosis;Discipline of obstetrics;Disparity;Early Intervention;early pregnancy;effective intervention;Endocrinology;Enrollment;Epidemiology;European ancestry;Exclusion;fasting plasma glucose;First Pregnancy Trimester;Future;Genes;Genetic;Genetic Markers;Genetic Research;genetic variant;genomic data;Genomics;Genotype;Gestational Diabetes;Glucose;Glycosylated hemoglobin A;Goals;Health;health disparity;high risk;high risk population;Impairment;improved;improved outcome;indexing;insight;Insulin;insulin secretion;insulin sensitivity;Knowledge;Measures;Mediating;Mediation;medically underserved;Metabolism;Minor;Molecular;multidimensional data;Natural History;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;OGTT;Outcome;Pacific Islander;Pacific Islands;Participant;Pathogenesis;Pathway interactions;perinatal period;Pharmacogenomics;Play;Population;Population Genetics;Positioning Attribute;Postpartum Period;potential biomarker;Precision Health;predictive marker;Pregnancy;Pregnancy in Diabetics;pregnant;Pregnant Women;Prevention;Prospective cohort;protective effect;recruit;Reduce health disparities;Research;Resources;response;Risk;risk stratification;risk variant;Role;Samoan;Sampling;screening;secondary outcome;Techniques;Testing;therapeutic target;Time;translational impact;treatment response;United States;Variant;Visit;Woman;Women's Health;Work

PROJECT_TITLE: CREBRF and risk of pregnancy and postpartum dysglycemia in American Samoan women

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Neurosciences;Regenerative Medicine

ORG_CITY: LARAMIE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF WYOMING

ORG_STATE: WY

PHR: Project Narrative This project aims to understand and develop approaches to tissue repair that utilize granular cell scaffolds, closely packed hydrogel microparticles that emulate tissue structures. This project focuses upon fundamental and applied aspects of tissue repair, including cell motility through granular scaffolds and their application in chronic diseases. This project has the potential to generate new therapeutic strategies for common health issues such as cartilage and nerve damage.

PI_NAMEs: SEVILLE, ROBERT SCOTT (contact)

PROGRAM_OFFICER_NAME: MATUKUMALLI, LAKSHMI KUMAR

PROJECT_TERMS: 3-Dimensional;3D Print;Acceleration;Address;Adopted;Adoption;Allografting;Architecture;Area;Award;Biochemistry;Biomedical Research;Cartilage;cartilage degradation;Cartilage injury;cartilage regeneration;cartilage repair;cell behavior;cell motility;Cell Proliferation;Cells;Cellular biology;Chondrocytes;Chronic Disease;Collaborations;density;design;Development;Discipline;disease model;Elements;Empiricism;Emulsions;Encapsulated;Ensure;Experimental Designs;Extracellular Matrix;fabrication;Face;Gel;Health;hydrogel scaffold;Hydrogels;immunoregulation;Infiltration;interest;Invaded;Knowledge;learning materials;Length;Ligands;Mentors;Microfabrication;Microfluidics;Molds;nanoscale;Nerve;nerve damage;Nerve Regeneration;network architecture;novel therapeutic intervention;Nutrient;Outcome;particle;Peripheral Nerves;Phase;physical property;Polymers;Porosity;Productivity;Property;rational design;Regenerative Medicine;Regulatory T-Lymphocyte;Reproducibility;Research;Research Personnel;response;Role;scaffold;Science;Shapes;Structure;Supporting Cell;Surface;Technology;Tissue Engineering;tissue repair;tissue trauma;Tissues;translational applications;Translations;Universities;Visualization;Waste Products;Work;Wyoming

PROJECT_TITLE: Wyoming IDeA Networks for Biomedical Research Excellence Phase 4 Team Science


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE This project will develop, implement, and evaluate a dental clinic intervention and mobile health unit community-based intervention designed to increase the proportion of evidence-based vaccinations among adolescents and adults and improve educational awareness and confidence in vaccinations among US-Mexico border Latinx and rural populations. This project will help to increase the quality and quantity of immunization services research and provide a framework to translate research into practice and policy resulting in increased immunization confidence and uptake. Project findings will contribute to evidence regarding the effectiveness of clinic-based and community-based interventions to address immunization health disparities.

PI_NAMEs: CARVAJAL, SCOTT CARTER;ELLINGSON, KATHERINE ;NUNO, THOMAS  (contact)

PROJECT_TITLE: Community-Based Participatory Research to Enhance Vaccine Uptake Across the Lifespan through Innovative Points of Access and Altering Norms in Border and Rural Regions


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: OXFORD

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: UNIVERSITY OF OXFORD

ORG_ZIPCODE: OX1 2JD

PI_NAMEs: VON DELFT, FRANK  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: age group;aspirate;Brain;Chemicals;Chemotherapy and/or radiation;Child;Childhood;Childhood Solid Neoplasm;chimeric antigen receptor T cells;clinical implementation;Clinical Trials;CRISPR/Cas technology;Crystallography;Dependence;Development;Disease;drug development;Drug Targeting;drug testing;early phase clinical trial;Ependymoma;Equilibrium;Ewings sarcoma;Glioma;high risk;improved;inhibitor;innovation;insight;Intervention;Malignant Childhood Neoplasm;Methods;Modeling;mortality;Neuroblastoma;novel;Oncogenic;Oncoproteins;patient engagement;Patient Representative;Patients;Pediatric Neoplasm;Pediatric Oncology;Pharmaceutical Chemistry;pre-clinical;protein degradation;Protein Inhibition;protein protein interaction;Proteins;Protocols documentation;Resistance;resistance mechanism;Risk;screening;Solid Neoplasm;structural biology;success;Survival Rate;synovial sarcoma;Therapeutic;Tumor Biology

PROJECT_TITLE: PROTECT - Harnessing PROTEin degradation for Advanced Childhood Tumors


ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Cancer-related health disparities in South Carolina are among the largest in the nation. The South Carolina Cancer Prevention and Control Research Network (SC-CPCRN) is applying for continued involvement as a CPCRN Collaborating Center that will allow us to draw on the extensive expertise of University of South Carolina-based faculty and staff committed to reducing these disparities by advancing dissemination and implementation (D&I) science through our well-recognized and established community-engaged research approach. We intend to engage the community, clinical partners, and other stakeholders in research, training, and technical assistance in order to increase the cancer prevention and control evidence base in South Carolina, build a workforce capable of effective D&I for cancer prevention and control strategies, and translate effective multi-level, community-clinical interventions into practice both in our state and nationally.

PI_NAMEs: ADAMS, SWANN ARP (contact);WILCOX, SARA

PROJECT_TITLE: Health Promotion and Disease Prevention Research Centers: 2024 Special Interest Project Competitive Supplements (SIPS)-South Carolina Cancer Prevention and Control Research Network IV

STUDY_SECTION_NAME: Special Emphasis Panel[ZDP1 FMC (04)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Vector-Borne Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Rift Valley fever virus (RVFV) is widespread throughout the entire African continent and in some endemic areas over 50% of the population is exposed by adulthood. Activity of the innate immune system is key to mitigating the severity of disease and the virus has actively evolved ways to abrogate innate immune function. In this project we will define how biologically relevant primary human cells recognize and respond to RVFV infection, determine which innate signaling pathways function to provide protection from disease, and define the contribution of hematopoietic cell infection to in vivo pathogenesis.

PI_NAMEs: MCELROY, ANITA K (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Acute;Adult;African;antagonist;Anti-viral Response;Area;Biological Response Modifiers;Cell Compartmentation;cell type;Cells;Clinical;Data;defined contribution;Disease;Encephalitis;Exhibits;Fever;Genes;Goals;Hematopoietic;Hepatitis;Hepatocyte;Human;human data;IFNAR1 gene;Immune;In Vitro;in vivo;Infection;innate immune function;innate immune mechanisms;Innate Immune Response;Innate Immune System;interferon antagonist;Interferon Inducers;Interferon Type I;Interferons;Knowledge;Macrophage;Mediating;monocyte;Mononuclear;Mus;Natural Immunity;Neurons;pathogen;Pathogenesis;Phagocytes;Population;prevent;Prevention;Production;programs;Proteins;receptor;Recombinants;Research;response;Rift Valley fever virus;Role;Secondary to;sensor;Severity of illness;Signal Pathway;Signal Transduction;Single Nucleotide Polymorphism;Testing;Tissue-Specific Gene Expression;TLR3 gene;TNF gene;Viral;Viral Pathogenesis;Virus;Virus Diseases;virus host interaction;virus identification;Virus Replication

PROJECT_TITLE: Innate immune recognition and response to Rift Valley fever virus


ORG_CITY: Aurora

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Candida albicans is a commensal fungus that colonizes the intestine of most healthy people but has the capacity to cause infections and exacerbate inflammation in susceptible people. Immune status determines risk for C. albicans-associated disease, but the impact of immune environment on C. albicans inherent pathogenic potential is not well understood. This proposal aims to comprehensively define the impact both homeostatic and pathogenic immune environments on C. albicans pathogenic potential.

PI_NAMEs: OST, KYLA  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: adaptive immune response;adaptive immunity;Adherence;Animal Model;Antibodies;Automobile Driving;Benign;Biology;Candida;Candida albicans;cell injury;cell type;Cells;Colitis;commensal microbes;Communities;Development;Disease;Environment;Foundations;Fungal Genes;fungus;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genetic Transcription;Goals;gut colonization;gut inflammation;gut microbiome;gut microbiota;Health;Heterogeneity;Human;Hyphae;Immune;Immune response;Immunity;immunodeficiency;Immunoglobulin A;Immunological Models;immunological status;in vivo;Individual;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Intestines;Invaded;Investigation;Knowledge;Life;Life Style;Link;Maintenance;member;Microbe;microbial;microbial community;microbiome;microbiota;Modeling;Morphology;mouse model;Mucous Membrane;murine colitis;Mus;novel;opportunistic pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Persons;Phenotype;Population;Predisposition;prevent;Process;programs;Recovery;Regulation;Risk;Role;Shapes;Study models;targeted treatment;Testing;Time;Work

PROJECT_TITLE: Dissecting the impact of immune environment on Candida albicans pathogenic potential in the gut


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it advances implementation science and cost evaluations of Managing Epilepsy Well (MEW) epilepsy self-management programs such as HOBSCOTCH and Project UPLIFT and promotes collaborative research via the MEW network. Emory University, together with Dartmouth College, will provide leadership, infrastructure, and the expertise needed to lead the MEW Network through its evolution of a focus on translation of our programs by describing their cost and impacts to increase their adoption by health systems and payers to have substantial public health impact.

PI_NAMEs: ESCOFFERY, NGOC-CAM  (contact);JOBST, BARBARA ;KEGLER, MICHELLE C;KIRIAKOPOULOS, ELAINE

PROJECT_TITLE: SIP-24-008: Managing Epilepsy Well (MEW) Network

STUDY_SECTION_NAME: Special Emphasis Panel[ZDP1 OHI (08)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bioengineering;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Firearms Research;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Prevention;Primary Health Care;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Cluster randomized trials comparing implementation strategies are often carried out in large health systems, where primary and secondary outcomes may be obtained from a combination of electronic health record (EHR) documentation and primary data collection through patient surveys. The proposed work will develop advanced statistical methods to combine multiple outcomes in a joint analysis with the goal of addressing biases inherent to each outcome such as survey non-response and measurement error. These methods will allow for a more rigorous, accurate, and precise analysis of the fidelity of two implementation strategies compared in the parent trial, ASPIRE, and will apply more broadly to implementation science research using cluster randomized trials.

PI_NAMEs: BEIDAS, RINAD SARY (contact)

PROGRAM_OFFICER_NAME: MARRO, MARY ACRI

PROJECT_TERMS: Acceleration;Address;Adopted;Affect;arm;Childhood;Clinic;clinical encounter;Cluster randomized trial;comparative effectiveness trial;compare effectiveness;comparison intervention;Confidence Intervals;cost effective;Data;Data Collection;data integration;Data Reporting;design;Documentation;Electronic Health Record;Evidence based practice;Feedback;firearm storage;Firearms;Future;Goals;Health system;implementation outcomes;implementation science;implementation strategy;implementation trial;insight;Joints;Measurement;Measures;Methodology;Methods;multiple data sources;novel;Outcome;Outcomes Research;Parents;patient population;Patient Self-Report;Patients;pragmatic trial;prevent;Prevention strategy;Primary Care;primary outcome;Procedures;programs;Property;Provider;Randomized;randomized trial;Recommendation;Reporting;Research;Resources;Safety;Sampling;secondary outcome;Secure;Selection Bias;simulation;Statistical Data Interpretation;Statistical Methods;Structure;suicidal adolescent;Suicide prevention;Surveys;Testing;tool;treatment effect;trial comparing;Visit;Well Child Visits;Work

PROJECT_TITLE: A Comparative Effectiveness Trial of Strategies to Implement Firearm Safety Promotion as a Universal Suicide Prevention Strategy in Pediatric Primary Care

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;HIV/AIDS;Human Genome;Immunotherapy;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: RICHMOND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative After accounting for potential confounders such as age, sex, and smoking, HIV has been identified as an independent risk factor for lung cancer. We aim to identify how non-cell autonomous changes may be a major mechanistic force which modified the tumor microenvironment of the HIV+ lung cancer patients.

PI_NAMEs: WINN, ROBERT A. (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: Accounting;Adenocarcinoma;Affect;Age;Age Years;anti-cancer;antiretroviral therapy;Antitumor Response;Belief;Biology;Biotechnology;cancer cell;cancer diagnosis;Cancer Etiology;Cancer Patient;CD3 Antigens;CD4 Positive T Lymphocytes;Cd68;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Fate Control;cell type;Cells;Cellular Structures;Cessation of life;chemotherapy;Clinical;Clinical Research;comorbidity;Data;Diagnosis;Disease-Free Survival;Disparity;Exhibits;Female;Flowers;Gene Expression;Genes;Granzyme;HIV;HIV Seronegativity;HIV Seropositivity;Immune;Incidence;Individual;Infiltration;innovation;Literature;Lymphocyte;Machine Learning;male;Malignant neoplasm of lung;Malignant Neoplasms;Measures;meter;Molecular;mortality;MS4A1 gene;Nature;novel;Oncogenic;Outcome;Patients;Platinum;Play;Probability;Process;Prognosis;programmed cell death ligand 1;programmed cell death protein 1;Progression-Free Survivals;Protein Isoforms;Publications;Publishing;Quality of life;Radiation therapy;Research;Resolution;Risk Factors;Role;Running;Sampling;Seminal;sex;Signal Transduction;Smoking;software development;Structure of parenchyma of lung;System;Systems Biology;Technology;Tissue Sample;transcriptome;transcriptomics;tumor;tumor microenvironment;Tumor-associated macrophages;tumor-immune system interactions;ultra high resolution

PROJECT_TITLE: High resolution spatial transcriptomics and machine learning to identify mechanisms responsible for the immunosuppressive tumor microenvironment in HIV+ lung cancer patients (Immuno/Microenvironment)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Immunotherapy;Nanotechnology;Women's Health Research

ORG_CITY: HADLEY

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: Project Narrative: Significance: This research is focused on the development of a new strategy for activation of therapeutics at tumor sites. This approach presents the possibility of generating active drugs only at tumor sites, reducing the off-target effects and minimizing health consequences for chemotherapy.

PI_NAMEs: ROTELLO, VINCENT M. (contact)

PROGRAM_OFFICER_NAME: CHEN, JERMONT

PROJECT_TERMS: 4T1;Cancer Biology;cancer cell;cancer therapy;catalyst;Cells;Chemistry;chemotherapy;Coculture Techniques;Coupled;Cytoprotection;Development;Dyes;efficacy evaluation;Elements;Encapsulated;Engineering;fabrication;fluorophore;Generations;Goals;Health;Immunology;In Situ;In Vitro;in vitro activity;in vivo;in vivo evaluation;Injections;Ligands;Macrophage;Malignant Breast Neoplasm;Mannose;mannose receptor;Mass Spectrum Analysis;Modeling;Modification;monolayer;mouse model;Mus;nanoGold;nanomaterials;nanoparticle;nanotherapeutic;nanovector;neoplastic cell;orthotopic breast cancer;particle;Pharmaceutical Preparations;Phenotype;Play;Porphyrins;pre-clinical;Process;Prodrugs;Research;Role;scaffold;Serum;Site;Specificity;Structure;System;targeted delivery;targeted treatment;Therapeutic;Transition Elements;Treatment Efficacy;tumor;Tumor-associated macrophages;uptake;Validation

PROJECT_TITLE: Targeting of Bio-orthogonal Chemotherapeutic Nanozymes to Tumor-Associated Macrophages

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Ovarian cancer is one of the leading causes of cancer death among individuals with ovaries and morbidity from the disease and its treatment is high. The overall objective of this proposal is to document the ongoing physical and psychosocial concerns, barriers and facilitators to care, and factors associated with unmet needs among ovarian cancer survivors. This research will have an important positive impact because identifying deficits in clinical and supportive care of ovarian cancer survivors is needed to design evidence-based interventions and public health programs to enhance the quality of life of cancer survivors.

PI_NAMEs: LASKA, MELISSA N.;PARSONS, HELEN M;VOGEL, RACHEL ISAKSSON (contact)

PROJECT_TITLE: UNTOLD: UNderstanding The experience of Ovarian cancer ? Life after Diagnosis: A Mixed Methods Approach

STUDY_SECTION_NAME: Special Emphasis Panel[ZDP1 OHI (03)]


ORG_CITY: BOSTON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE The Massachusetts Cancer Prevention and Control Research Network (MCPCRN) will contribute to the broad CPCRN network to support cross-center efforts to accelerate the implementation and reach of evidence-based interventions for cancer prevention and control. Our research focuses on tobacco control in community health centers, an building CHC's capacity for engaging in implementation research and using their data to improve care delivery.

PI_NAMEs: EMMONS, KAREN M. (contact);GORTMAKER, STEVEN L


ORG_CITY: CHAPEL HILL

ORG_DEPT: NUTRITION

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE For more than 20 years, the Cancer Prevention and Control Research Network (CPCRN) has been the national leader in the collaborative development and translation of knowledge to improve cancer prevention and control in medically underserved communities, with investigators at UNC leading the CPCRN Coordinating Center and one of eight Collaborating Centers. We propose to continue to leverage our successful leadership experience, community orientation, inclusive approach to membership and governance, and extensive resources, tools and policies and procedures developed to support network collaboration to advance the goals of the CPCRN and the CDC’s Prevention Research Centers Program. The expected impact of this work on cancer health outcomes and cancer health disparities is significant, given the breadth and depth of cancer prevention and control science generated, the multidisciplinary and community-engaged nature of collaborations, and the focus on pragmatic, scalable, and health equity-focused interventions among members and community collaborators.

PI_NAMEs: AMMERMAN, ALICE S (contact);BRENNER, ALISON T;HIRSCHEY, RACHEL ;WHEELER, STEPHANIE BROOKE

PROJECT_TITLE: SIP 24-003 Cancer Prevention and Control Research Network (CPCRN) Coordinating & Collaborating Centers at the University of North Carolina at Chapel Hill


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_DEPT: SURGERY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE Research over the last two decades has revealed roles for the endolysosomal system in Alzheimer’s, Parkinson’s and other types of neurodegeneration disorders. Nevertheless, many questions remain concerning how the endolysosomal system is organized in health and disease. In this proposal, we seek to develop an in-depth understanding of proteome landscape and structural anatomy of the major organelles that make up the endolysomal system, and to explore how risk alleles linked with Parkinson’s disease alter this landscape.

PI_NAMEs: HARPER, JEFFREY W (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: Acceleration;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease related dementia;amyloid precursor protein processing;Anatomy;antiporter;Architecture;Autophagocytosis;Binding;Biochemical;Biochemistry;Biogenesis;Biological;Biology;Cell membrane;Cells;Chloride Ion;Communities;Complex;Couples;crosslink;Data;Defect;Degradation Pathway;Destinations;Disease;embryonic stem cell;Endocytosis;Endoplasmic Reticulum;Endosomes;Equilibrium;Event;expectation;experimental study;Functional disorder;Funding;Generations;Genetic;Genetic Diseases;genetic variant;genome wide association study;Golgi Apparatus;Health;Homeostasis;Immunoprecipitation;In Vitro;Individual;Induced Neurons;Information Networks;Integral Membrane Protein;lens;Link;lipidomics;Lipids;LRRK2 gene;Lysosomes;Maps;Mass Spectrum Analysis;Membrane;Membrane Proteins;Methods;Mitochondria;Molecular;molecular assembly/self assembly;mutant;Nerve Degeneration;Neurodegenerative Disorders;neurogenesis;Neurons;novel;Organelles;Outcome;Parkinson Disease;Pathway interactions;Phenotype;predictive tools;presenilin-1;protein complex;Proteins;Proteome;Proteomics;Quality Control;receptor;receptor binding;Recycling;Regulation;Research;Resources;risk variant;Role;Route;secretase;Sphingolipids;Structural Models;Synapses;System;tau aggregation;trafficking;Ubiquitin;Variant;vesicle transport;Work

PROJECT_TITLE: Endolysosomal Proteome Landscapes Through the Lens of Neurodegenerative Risk Alleles

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Digestive Diseases;Genetics;Liver Disease;Nutrition;Substance Misuse

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Alcohol abuse and its associated liver diseases represent a significant public health challenge, and with no effective medical therapies, abstinence remains the mainstay for treatment. The liver secreted hormone, FGF21, is potently induced by ethanol and has profoundly beneficial effects on the brain, suppressing alcohol consumption, and on the liver, improving metabolic function and protecting against injury. We have identified a novel IRF3 inhibitory pathway that is a critical regulator of FGF21 transcription, and by targeting this pathway, we propose a therapeutic strategy for increasing FGF21 and its beneficial effects on alcohol abuse.

PI_NAMEs: PATEL, SURAJ J (contact)

PROGRAM_OFFICER_NAME: LIN, LI

PROJECT_TERMS: Abstinence;Acute;Alcohol abuse;Alcohol consumption;alcohol effect;alcohol use disorder;Alcoholic Intoxication;Alcoholic Liver Diseases;Alcohols;Alleles;Apoptosis;Behavior;Behavioral;Binding;Brain;Carbohydrates;Chromatin;Chronic;Clinical Trials;Data;Diet;Disease Progression;DNA-Binding Proteins;Ethanol;feeding;fibroblast growth factor 21;gain of function;gene network;Genes;Genetic Transcription;glucose metabolism;Goals;Health;hepatocellular injury;Hepatocyte;Hormone secretion;Hormones;Human;human disease;immunoregulation;imprint;improved;in vivo;Inflammation;Injury;innovation;insight;Insulin Resistance;Intoxication;IRF3 gene;Link;lipid metabolism;Liver;Liver diseases;liver inflammation;liver injury;liver metabolism;loss of function;LoxP-flanked allele;Maps;Mediating;Mediator;Medical;Metabolic;Metabolic dysfunction;Metabolism;mimetics;Modeling;motor impairment;Mus;mutant;Natural Immunity;novel;novel therapeutics;Obesity;overexpression;Pathway interactions;Patients;Physiological;PLAGL1 gene;Play;preference;Prevalence;Process;Proliferating;Promoter Regions;Public Health;Regulation;Repression;Research;response;Risk Factors;Role;Sedation procedure;Severity of illness;Signal Transduction;stressor;Techniques;Testing;Therapeutic;Transcription Factor 3;Transcription Repressor;Transcriptional Regulation;transcriptome;treatment strategy;Water consumption;Work

PROJECT_TITLE: Identifying an immunoregulatory axis for FGF21 in alcohol consumption

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ORG_CITY: KANSAS CITY

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI KANSAS CITY

ORG_STATE: MO

PHR: Project Narrative (3 sentences) Voltage-gated ion channels conduct ions across biological membranes in response to membrane voltage changes and are important targets for treating diseases such as arrhythmias, epilepsy, periodic paralysis and pain disorders. This administrative supplement requests a Nano-imager that can automatically perform single-molecule FRET imaging to reveal the real-time conformational dynamics of voltage-gated ion channels induced by electrical voltage or drug molecules. Acquisition of the Nano- imager will allow us to implement the key studies proposed in the parent award to uncover the structural mechanisms of channel function and drug modulation and, more importantly, provide invaluable opportunities to undergraduate students at UMKC, an undergraduate-focused university with limited resources, to learn and use the cutting-edge imaging technique.

PI_NAMEs: WANG, SHIZHEN  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Action Potentials;Administrative Supplement;Anti-Arrhythmia Agents;Anticonvulsants;Arrhythmia;Behavior;Biological;Cardiac Myocytes;Cardiovascular Diseases;Cations;Cells;Chemical Structure;Complex;Computer software;Cryoelectron Microscopy;Disease;Drug Binding Site;Drug Modulation;Epilepsy;Equipment;experience;fluorescence microscope;Fluorescence Resonance Energy Transfer;Human;Image;imager;Imaging Techniques;Ion Channel Gating;Ions;Kinetics;Learning;Life;Measurement;Membrane;Mental disorders;Microscope;millisecond;Molecular;Molecular Conformation;Molecular Target;nano;nanoimaging;Nervous System Disorder;Pain Disorder;parent project;periodic paralysis;Pharmaceutical Preparations;Productivity;Research;Resolution;Resources;response;Rest;sensor;single-molecule FRET;Site;Sodium;Sodium Channel;Structural Models;Structure;Students;System;Techniques;Temperature;Time;Training;undergraduate student;Universities;voltage;Work

PROJECT_TITLE: Structural dynamics of voltage-gated ion channels and their implications for ionpermeation and drug modulation

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Eczema / Atopic Dermatitis;Food Allergies;Microbiome;Nutrition;Pediatric;Prevention

PHR: Project Narrative for the SEAL (Stopping Eczema and ALlergy) Study Food allergy (FA) is an epidemic among children in the U.S., U.K., and other countries. By reducing dry skin, the duration and severity of eczema and preventing eczema exacerbations with skin barrier protection and anti-inflammatory creams, we aim to significantly reduce the incidence of food allergy.

PI_NAMEs: LACK, GIDEON ;LEUNG, DONALD YM;NADEAU, KARI C. (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: 1 year old;3 year old;Allergens;Allergic inflammation;allergic response;Allergy to peanuts;Anti-Inflammatory Agents;arm;Atopic Dermatitis;atopy;B-Lymphocytes;Basophils;Biological Markers;Blood;Caring;CD8B1 gene;Cells;Child;Clinical;Clinical Research;cohort;commensal bacteria;comparison control;Complex;Country;Cream;Cytometry;Development;Disease;Dryness;dysbiosis;Eczema;Emollients;Epidemic;Epithelium;filaggrin;food allergen;food challenge;food consumption;Food Hypersensitivity;Functional disorder;Genes;genetic testing;high risk infant;Hypersensitivity;IgE;immune function;Immune response;Immunoglobulin Class Switching;improved;Incidence;infancy;Infant;Inflammation;Inhalant dose form;Interleukin-10;Interleukin-13;Intervention;Intervention Trial;Learning;Life;Lipids;Lymphoid Cell;mast cell;Mediating;Metagenomics;microbial;Monitor;monocyte;novel;Oatmeal Powder;Oral;oral tolerance;Participant;patient retention;Prevalence;prevent;Prevention;primary endpoint;prospective;Proteins;Proteomics;Randomized;Recommendation;recruit;Regulatory T-Lymphocyte;repaired;Research;respiratory;Risk;Role;secondary outcome;Secondary Prevention;Severities;Skin;skin barrier;Skin Care;skin microbiota;Somatic Mutation;standard of care;Staphylococcus aureus;Steroids;Stratum corneum;T cell receptor repertoire sequencing;Techniques;Testing;Th2 Cells;Time;Topical application;transcriptomics;treatment arm;treatment group;trial design;TSLP gene;Variant;γδ T cells

PROJECT_TITLE: SEAL (Stopping Atopic dermatitis and ALlergy) Study: Prevent allergy by enhancing the skin barrier


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Primary Health Care;Social Determinants of Health;Substance Misuse

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

ORG_STATE: CA

PHR: PROJECT NARRATIVE While the entire United States has seen a stark rise in overdose deaths since 2020, Los Angeles County California is experiencing a particularly severe opioid epidemic due to the rise of fentanyl and lack of widespread treatment for opioid use disorder (OUD). Without a systematic assessment of treatment gaps and health disparities, it will be difficult to improve treatment for patients who need it most. This work will link data from disparate systems to construct the OUD cascade of care to enable identifying gaps in care and disparities among subgroups that can be targeted with quality improvement efforts.

PI_NAMEs: KALMIN, MARIAH  (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: Accident and Emergency department;addiction;Address;Administrator;Area;Back;Benchmarking;California;care systems;Caring;Cessation of life;Characteristics;Continuity of Patient Care;County;Data;Disparate;Disparity;Disparity population;disparity reduction;Effectiveness;Electronic Health Record;Ethnic Origin;Evidence based treatment;Excision;experience;Fentanyl;Funding;Geographic Locations;Goals;health disparity;Health Services;Health Services Accessibility;Health system;Healthcare;HIV;Housing;Improve Access;improved;information organization;Information Systems;inpatient service;Inpatients;Intention;Intervention;Link;Los Angeles;Manuals;Measurement;medical specialties;medication for opioid use disorder;Mental Health;Methadone;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;opioid epidemic;opioid use;opioid use disorder;Outpatients;Overdose;overdose death;Patient Care;patient privacy;Patients;payment;Performance;Persons;Pharmaceutical Preparations;Policies;Policy Maker;Population;prescription monitoring program;Primary Care;privacy protection;Process;programs;Public Health;Public Sector;Race;Research;response;safety net;Science;sex;sociodemographics;substance abuse prevention;substance use;Substance Use Disorder;substance use treatment;System;telehealth;Time;United States;urgent care;Visit;waiver;Work

PROJECT_TITLE: The Cascade of Care for Patients with Opioid Use Disorder Identified Through a Large Public Health System

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 LXF-E (A1)]


ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE The CPCRN Collaborating Center at the University of Pennsylvania will work with the CPCRN network and partners to accelerate the implementation of evidence-based cancer prevention and control strategies in communities and enhance large-scale efforts to reach underserved populations, reduce cancer risk, improve screening utilization, reduce death from cancer, and ameliorate health disparities in the community and within health systems. The main activities of the UPenn PRC collaborating center will be CPCRN Network participation, participation in CPCRN workgroup projects, and two Center-specific initiatives: 1) our core research project, Implementation Research to Increase Risk Assessment and Referral for Breast and Colorectal Cancer in Federally Qualified Health Centers, and 2) the CPCRN Scholars Program.

PI_NAMEs: GLANZ, KAREN  (contact)

PROJECT_TITLE: Prevention Research Centers' Cancer Prevention and Control Research Network: UPenn Prevention Research Center


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative CDC’s Nutrition and Obesity Policy Research and Evaluation Network (NOPREN) is the nation’s premier platform for the collaborative translation and dissemination of nutrition policy, systems, and environmental (PSE) research. We will continue our highly successful leadership of NOPREN’s Coordinating Center for another five years in order to expand its reach and impact, which we will achieve by increasing the field’s capacity to conduct high-quality transdisciplinary research that accelerates implementation of DNPAO’s nutrition and obesity-prevention strategies; disseminating research findings to internal, external, and non- traditional, interdisciplinary partners; and enhancing coordination and engagement of multi-disciplinary partners. In support of DNPAO’s Food Service and Nutrition Guideline PSE strategy and NOPREN’s goals, we will also use an implementation science approach to develop and deploy a measurement tool supporting dissemination of nutrition guidelines in charitable food settings.

PI_NAMEs: RAMIREZ-VALLES, JESUS  (contact)

PROJECT_TITLE: Building on our Success as the NOPREN Coordinating Center


ADMINISTERING_IC: FD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: TUCSON

ORG_NAME: CRITICAL PATH INSTITUTE

PHR: PROJECT NARRATIVE Critical Path Institute (C-Path) was established in 2005 under the auspices of FDA’s Critical Path Initiative to catalyze advances in medical innovation and regulatory science, by leading teams of stakeholders from industry, government, academia, and advocacy organizations to generate actionable solutions to address unmet needs in drug development. With renewed funding C-Path will be able to continue developing impactful Critical Path Public-Private Partnerships and advancing innovative, collaborative projects in research, education, and outreach for fostering medical product innovation, enabling the acceleration of medical product development.

PI_NAMEs: ROMERO, KLAUS  (contact)

PROGRAM_OFFICER_NAME: MUMMANENI, PADMAJA

PROJECT_TITLE: Critical Path Public Private Partnerships

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CDER-T (10)]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

PHR: PROJECT NARRATIVE Systematic reviews (SRs) of healthcare interventions should identify patient safety concerns; however, many SRs are designed to assess benefits, and preliminary evidence suggests that conclusions about harms in SRs might not be trustworthy. Using >19,000 SRs of drugs for which we have full texts (including >4,000 overlapping reviews), and using innovative methods for analysis (e.g., natural language processing), we will examine whether information about safety in SRs is consistent, whether SRs address safety concerns identified using real-world evidence, and whether SRs are consistent with safety information on drug labels. Based on best evidence, including findings from this study, we will develop contemporary guidance for synthesizing and reporting safety information in SRs.

PI_NAMEs: KILICOGLU, HALIL ;MAYO-WILSON, EVAN  (contact)

PROGRAM_OFFICER_NAME: WAGNER, MEGHAN

PROJECT_TITLE: Improving results and conclusions about harms in systematic reviews of drugs

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: NARRATIVE Viruses that are able to establish persistent or chronic infections have developed strategies to suppress immune mechanisms that would normally eradicate the virus. Regulating inflammation in the face of persistent infection is also critical as many of the long-term problems of chronic infection are due to persistent inflammation, including increased risk of developing cancer. Our new data have uncovered an unexpected role for IL-17 in helping to limit T cell activation and inflammation as persistent infection becomes established, and here we propose to explore the sources and functions of IL-17 in immunoregulation of antiviral response.

PI_NAMEs: MCGEACHY, MANDY J (contact)

PROGRAM_OFFICER_NAME: LEITNER, WOLFGANG W

PROJECT_TERMS: Adoptive Transfer;Anti-viral Response;Antibodies;antiviral immunity;Attention;Automobile Driving;Bacteria;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Count;Cell Physiology;Cell Proliferation;Cell Survival;Cells;cellular targeting;Chronic;chronic autoimmune disease;chronic infection;Chronic Phase;Clinical;Data;design;Development;Elements;exhaustion;extracellular;fungus;Future;Gene Expression Profiling;Genes;Genetic;Hepatitis B;HIV;IL17 gene;Immune;Immune response;Immunity;immunopathology;immunoregulation;Immunosuppression;improved;Infection;Inflammation;Inflammatory Response;Interferon Type II;Invaded;Kinetics;Lead;Lymphocytic choriomeningitis virus;Lymphoid;Lymphoid Tissue;Malignant Neoplasms;Mediating;Metabolic;Metabolic Pathway;microbiota;Modeling;Molecular Profiling;Morbidity - disease rate;Mus;novel;Outcome;pathogen;Pathology;Pathway interactions;Persons;Population;Production;Proliferating;Regulation;Regulatory T-Lymphocyte;response;Reticular Cell;Risk;Role;Signal Transduction;Source;Stromal Cells;Surface;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Therapeutic Intervention;Time;tissue repair;Viral;Virus;Virus Diseases

PROJECT_TITLE: IL-17 regulation of type-1 immunity in chronic viral infection

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: MADISON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The prevalence and impact of autism are widely known, but the brain basis of autism remains unclear, particularly in the understudied region of the brainstem. The proposed research will solve an urgent public health need to provide a more complete depiction of brainstem-inclusive, whole-brain networks in reference to the core, sensorimotor, and autonomic features prevalent in autistic children. In line with the NICHD and IACC's priorities and with the NIH's mission, the proposed work will help promote health and well-being through improved knowledge of the neurobiological basis of the core diagnostic and co-occurring features of autism, enabling the development of biologically informed interventions.

PI_NAMEs: TRAVERS, BRITTANY GAIL (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: 9 year old;adolescent with autism spectrum disorder;Age;Anatomy;Autism Diagnosis;autism spectrum disorder;autism symptoms;autistic;autistic children;Behavior;Behavioral;Biology;Brain;Brain region;Brain Stem;Cell Nucleus;Child;communication behavior;community advisory board;Complex;Consultations;Data;Data Set;Development;Diagnosis;Diagnostic;Digestion;Family member;feeding;Feeding behaviors;graph theory;Hand;Health Promotion;High Prevalence;Image;improved;in vivo;indexing;Individual;Individual Differences;individuals with autism spectrum disorder;innovation;insight;Intervention;Knowledge;Life;life span;Magnetic Resonance Imaging;Maps;Mastication;Measures;Metabolic;Methodology;Mission;Motor;National Institute of Child Health and Human Development;neural;Neurobiology;neuroimaging;Outcome;peer;Personal Satisfaction;Persons;Phenotype;Prevalence;prevent;Property;Public Health;Quality of life;repetitive behavior;Research;Respiration;respiratory;Reticular Formation;Role;Sensory;Sinus;Sinus Arrhythmia;skills;Social Behavior;social communication;Symptoms;Tactile;Techniques;Technology;Testing;tractography;United States National Institutes of Health;Variant;white matter;Work;Youth

PROJECT_TITLE: Brainstem Contributions to Sensorimotor and Core Symptoms in Children with Autism Spectrum Disorder

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative: Our prior work has resulted in the ability to eliminate all microglia from the brain, via clinically utilized colony- stimulating factor 1 receptor (CSF1R) inhibitors, and to then, following CSF1R inhibitor withdrawal, repopulate the microglia-depleted brain with 1) a new microglial tissue, 2) white matter microglia, or 3) bone marrow-derived monocytes, utilizing a variety of CSF1R inhibitor conditions and paradigms. Here, we will extend our research into more translationally relevant directions to explore how to produce the beneficial effects of microglial repopulation, via transient CSF1R inhibition reprogramming of microglia, without the necessity of excessive microglial death, as well as the utility of microglial replacement with functional bone marrow-derived monocytes for the therapeutic benefit of genetic diseases associated with microglia dysfunction – namely the lysosomal storage disorder Sandoff disease. Finally, we will determine the impact of monocytes on the pathogenesis of Alzheimer's disease using complementary mouse models combined with microglial replacement techniques, with an emphasis on studying the downstream events of monocyte central nervous system infiltration and their plaque-associated interactions.

PI_NAMEs: GREEN, KIM  (contact)

PROJECT_TERMS: Adult;Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Amyloid;Animal Disease Models;Animals;Award;Behavioral;Biochemistry;Biological Process;Biology;Bone Marrow;Brain;brain cell;Brain Diseases;Cell Physiology;cell type;Cells;Central Nervous System;Central Nervous System Diseases;Cessation of life;Chronic;Clinical;clinically relevant;Cognitive;conditioning;Cranial Irradiation;Cuprizone;Demyelinations;Dependence;Development;Disease;Drug Targeting;Engraftment;Event;Excision;fascinate;Fostering;Functional disorder;Funding;Gene Expression;Genetic Diseases;Gliosis;Immunohistochemistry;Infiltration;Inflammatory;inhibitor;Injury;interest;irradiation;Macrophage Colony-Stimulating Factor Receptor;Mediating;Methods;Microglia;Modeling;monocyte;mouse model;Mus;myelination;Myeloid Cells;Neurites;Neuroglia;Neurosciences;novel;novel therapeutics;Oligodendroglia;Onset of illness;Pathogenesis;Pathology;Peripheral;pharmacologic;Phase;Population;Process;programs;Proliferating;Property;protein TDP-43;receptor;Receptor Inhibition;Receptor Signaling;reconstitution;Recovery;Research;Role;Route;Sandhoff Disease;single nucleus RNA-sequencing;subventricular zone;Synapses;tau Proteins;Techniques;Therapeutic;Tissues;tool;transcriptome sequencing;transcriptomics;white matter;Whole-Body Irradiation;Withdrawal;Work

PROJECT_TITLE: Origins, properties, and therapeutic potential of cells that repopulate the microglia-depleted adult brain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Z (55)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Hematology;Human Genome;Orphan Drug;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Genetic defects in the cohesin complex member Stag2 are recurrently mutated in various human cancers and lead to disruption of tissue-specific gene expression through DNA looping. Using cutting-edge epigenomic techniques, primary patient samples, and a reversible in vivo Stag2 mouse, we will map Stag2-specific chromatin looping in hematopoietic stem and progenitor cells and functionally assess their contribution to the lineage fate and self-renewal. Using these techniques in combination with sequential mutagenesis of the AML driver mutations NPM1c and FLT3ITD, we will determine the effects of altered chromatin structure on leukemogenesis, the effects on therapeutic response, and the requirement of Stag2 for leukemia maintenance.

PI_NAMEs: VINY, AARON D (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: 3-Dimensional;Alleles;biobank;Biological Assay;Bone Marrow;Cells;Chromatin;chromatin immunoprecipitation;Chromatin Loop;Chromatin Structure;cohesin;Complex;Dependence;driver mutation;Enhancers;Epigenetic Process;epigenomics;Event;FLT3 gene;FLT3 inhibition;Gene Expression;Genetic;Genetic Transcription;Hematopoietic;Hematopoietic stem cells;Hi-C;hip replacement arthroplasty;Human;In Vitro;in vivo;leukemia;leukemogenesis;Maintenance;Malignant Neoplasms;Maps;member;Menin;Modeling;molecular pathology;multiple omics;Mus;Mutagenesis;mutant;Mutate;Mutation;new therapeutic target;novel;Output;Patients;Phenocopy;Phenotype;Population;prevent;progenitor;recombinase;Recurrence;Regimen;restoration;Role;Sampling;Secondary acute myeloid leukemia;self-renewal;stem;stem cell population;stem cell self renewal;System;targeted treatment;Techniques;Therapeutic;Tissue-Specific Gene Expression;Transcriptional Regulation;transcriptome sequencing;treatment response;Validation

PROJECT_TITLE: The role of the cohesin complex in hematopoietic transformation and leukemia maintenance

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Obesity;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative The proposed study tests the efficacy of an innovative physical activity promotion intervention targeting Hispanic and Black mothers who attend their children’s sports practices. Using a cluster randomized trial with a waitlist control, we will partner with eight youth football and cheerleading organizations to test the efficacy of the intervention for increasing moderate to vigorous physical activity. This study, along with the diversity statement and Plan for Enhancing Diverse Perspectives (PEDP) demonstrate the PI’s commitment to Diversity, Equity, Inclusion, and Accessibility (DEIA).

PI_NAMEs: VON ASH, TAYLA  (contact)

PROGRAM_OFFICER_NAME: HERREN, OLGA MARINA

PROJECT_TERMS: Accelerometer;acceptability and feasibility;Address;arm;Behavior;behavior change;Black Populations;Black race;black women;Body mass index;Child;Child Care;Chronic Disease;Clinical Trials;Cluster randomized trial;community engaged approach;community intervention;community organizations;community setting;Control Groups;cost;Disparity;efficacy testing;equity, diversity, and inclusion;ethnic disparity;ethnic minority;evidence base;exercise intervention;Exhibits;experience;Face;Family;Feedback;follow-up;Fostering;Geography;Goals;group intervention;Health;health disparity;health literacy;high risk;high risk population;Hispanic;Hispanic Populations;Hispanic Women;Individual;innovation;Intervention;intervention effect;Low income;low socioeconomic status;Maintenance;Manuals;Manufactured football;Measures;Mediating;Mediator;Mentors;Mission;moderate-to-vigorous physical activity;Mothers;motivational enhancement therapy;Names;novel;Obesity;Outcome;Participant;Patient Self-Report;Persons;Physical activity;physical inactivity;Pilot Projects;pilot test;pilot trial;Population;programs;racial disparity;racial minority;Randomized;recruit;Reporting;Research;Rhode Island;Sampling;Science;Seasons;Self Efficacy;Social support;Socioeconomic Status;Sports;Students;theories;Time;Training;Transportation;Travel;treatment arm;Treatment Efficacy;Waiting Lists;Woman;Work;Writing;Youth;youth sports

PROJECT_TITLE: Leveraging youth sports practices to increase physical activity among racial and ethnic minority mothers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-H (55)]


ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE This project will study a large network of hospitals across the U.S. to study hospital care for newborns with prenatal substance exposure in collaboration with patient stakeholders who have lived experience with perinatal substance use and recovery. Using multiple approaches for measuring hospital practices and their impact on patient-level outcomes, we will generate novel and important recommendations for improving healthcare equity and overall quality, which are amenable to rapid implementation across U.S. hospitals. Thus, the proposed research is relevant to AHRQ’s mission to produce evidence to improve healthcare safety, quality, and equity for newborns and families affected by prenatal substance use.

PI_NAMEs: GOYAL, NEERA ;KAIR, LAURA R (contact)

PROGRAM_OFFICER_NAME: SAGATOV, ROBYN

PROJECT_TITLE: Clinical Care of Newborns with Prenatal Substance Exposure: A National Study


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Lung cancer is the leading cause of cancer-related mortality in the U.S., accounting for approximately 1 in 5 cancer-related deaths. Annual Low-Dose Computed Tomography screening for lung cancer is recommended by the U.S. Preventive Services Task Force, but only 6.5% of eligible individuals were screened in 2020, and there are major health inequities in LCS related to race/ethnicity and socioeconomic status. The long-term goal of the project to increase the reach of LCS among low resource healthcare settings and populations that have been historically marginalized.

PI_NAMEs: ESTABROOKS, PAUL  (contact);SCHLECHTER, CHELSEY ;WETTER, DAVID W

PROGRAM_OFFICER_NAME: DARLING, NATALIE

PROJECT_TITLE: Digital Health Implementation Strategies to Improve Lung Cancer Screening Among Safety-Net Clinics

STUDY_SECTION_NAME: Special Emphasis Panel[ZDP1 FMC (04)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: SANTA CRUZ

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: PROJECT NARRATIVE  This proposal studies how the classical psychedelic psilocybin rescues the deleterious effects of chronic stress, a major risk factor for mental illnesses. We investigate psilocybin’s effects across the brain’s organizational hierarchy, from synapses and neural circuits to large-scale cortical networks and ultimately mouse behavior. Such studies will reveal the fundamental mechanisms of psychedelics’ impact on brain and behavior and provide an integrated, mechanistic foundation for their applications in psychiatry.

PI_NAMEs: ZUO, YI  (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: Acute;Affect;Animal Model;Attention;Behavior;Behavior Therapy;Behavioral;behavioral outcome;Brain;Brain region;Calcium;calmodulin-dependent protein kinase II;catalyst;Chemicals;Chronic stress;Clinical;clinical application;Clinical Trials;Cognitive;Conscious;Defect;Dendritic Spines;Dependence;dosage;environmental enrichment for laboratory animals;Excitatory Synapse;experience;experimental study;flexibility;Foundations;functional plasticity;Genetic;Goals;Hallucinogens;Hour;Housing;Human;Image;imaging genetics;in vivo;in vivo imaging;information processing;interest;Knock-in Mouse;Knowledge;Left;Medial;memory consolidation;Mental disorders;Microscopy;Modification;mouse genetics;Mus;neural;neural circuit;neurobiological mechanism;neuronal circuitry;Neuronal Plasticity;Neurons;neuropathology;neuropsychiatric disorder;Pharmaceutical Preparations;postsynaptic;Prefrontal Cortex;Protein Isoforms;Psilocybin;Psychiatry;Psychotherapy;Recovery of Function;Renaissance;Research;Risk Factors;Role;Safety;Sensory;Signaling Molecule;Site;small molecule;Stress;sustained recovery;Synapses;Synaptic plasticity;synaptogenesis;temporal measurement;Testing;Therapeutic;Therapeutic Effect;tool;treatment-resistant depression;two-photon;United States Food and Drug Administration;Vertebral column;Visualization

PROJECT_TITLE: Synaptic circuit mechanisms underlying psilocybin's therapeutic effects in the stressed brain

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

ORG_CITY: GLASSBORO

ORG_NAME: ROWAN UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative The mainline treatments for pain are opioid analgesics which are unfortunately accompanied by significant side effects including tolerance, dependence, and addiction. A novel receptor system PEN-GPR83 regulates morphine antinociception however, the neurobiological mechanism by which this interaction occurs is unknown. The long-term goal of this project is to reveal mechanism by which PEN-GPR83 decouples the beneficial from the detrimental effects of opioids.

PI_NAMEs: FAKIRA, AMANDA KATHLEEN (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: abuse liability;addiction;Address;Affect;Agonist;Analgesics;antagonist;antinociception;behavioral study;Biochemistry;Biological Process;Brain;Brain region;calcium indicator;Cells;chronic pain patient;Complex;conditioned place preference;Data;Dependence;design;Development;Electrophysiology (science);Engineering;Exposure to;G-Protein-Coupled Receptors;gamma-Aminobutyric Acid;Goals;Image;In Vitro;in vivo;inhibitory neuron;Intervention;Ligands;Measures;Mediating;Membrane;mesolimbic system;midbrain central gray substance;Morphine;mu opioid receptors;Mus;Neuroanatomy;neurobiological mechanism;neuronal excitability;Neurons;Neuropeptide Receptor;Neuropeptides;Nociception;novel;novel therapeutics;Opioid;opioid abuse;Opioid agonist;Opioid Analgesics;optogenetics;Oxycodone;Pain;Pain management;pain relief;Pathway interactions;Pharmaceutical Preparations;prescription opioid;Proteins;Rabies virus;receptor;receptor function;Regulation;Rewards;Risk;Role;side effect;Signal Transduction;Site;Slice;small molecule;Source;Spinal Cord;Stimulus;Synapses;System;Testing;Work

PROJECT_TITLE: Targeting PEN-GPR83 as a as a strategy to reduce opioid abuse liability

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


PHR: PROJECT NARRATIVE: There is considerable debate around the optimal nomenclature for low-grade (grade group 1, GG1) prostate cancer, reflecting in part challenges with patient understanding of pathology reports. Recruiting from the diverse, population-based California Cancer Registries (CCR), we will conduct bilingual qualitative studies on patient perspectives about the nomenclature and optimized reporting of low-grade prostate cancer. We will follow this with a quantitative discrete choice experiment and randomized trial among over 500 additional CCR patients to identify consensus preferred nomenclature and patient-centered pathology reporting options.

PROJECT_TITLE: Patient Perspectives on Relabeling and Pathology Reporting for Grade Group 1 Prostate Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZDP1 FMC (07)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PITTSBURGH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: Chronic insomnia is one of the most common health problems among Veterans and significantly impacts their health, function, and quality of life. Sedative-hypnotic medications are the most common treatment despite mixed effectiveness and are associated with numerous risks that can further impact Veteran function. An intervention combining evidence-based interventions for deprescribing sedative-hypnotics and behavioral interventions for insomnia can help to optimize sleep and functional outcomes for Veterans with a desire to reduce or stop using these medications. Furthermore, by delivering these interventions through an easy to use and highly accessible digital platform can provide additional benefits to Veterans, especially those with limited time and access to engage in traditional in-person interventions. The Clinician Operated Assistive Sleep Technology (COAST) is an efficient, scalable, and adaptable platform that can help providers to reach more Veterans and provide evidence-based care that translates to improved health and function.

PI_NAMEs: BRAMOWETH, ADAM DANIEL (contact)

PROJECT_TERMS: Accidents;Address;Aftercare;Air;arm;Artificial Intelligence;barrier to care;Behavior Therapy;Behavioral;Biological Process;care delivery;Caring;Chronic;Chronic Insomnia;Clinic;Clinical;Clinical Pharmacists;clinical practice;Clinical Psychology;Clinical Trials;cloud based;Cognitive;Cognitive Therapy;common treatment;Communication;Communities;Consultations;COVID-19 impact;COVID-19 pandemic;Dependence;Development;Diagnosis;digital;digital health;digital intervention;digital platform;digital technology;Disease;Dreams;effective intervention;Effectiveness;effectiveness testing;Enrollment;Ensure;evidence base;Evidence based intervention;Fatigue;flexibility;Foundations;Functional impairment;functional independence;functional outcomes;Funding;Health;Health Services;Health Services Accessibility;Home;hypnotic;Impaired cognition;improved;improvement on sleep;Injury;innovation;Intervention;Link;Medical;Medical Societies;Medicine;Mental disorders;Mental Health;Methodology;Military Personnel;mobile application;new technology;novel strategies;operation;Outcome;patient home care;personalized care;Persons;Pharmaceutical Preparations;Pharmacists;Pharmacy (field);Pharmacy facility;physical impairment;Pilot Projects;pilot test;post intervention;Provider;Psychologist;Psychotherapy;Quality of life;Recommendation;recruit;rehabilitation research;Research;research and development;Risk;Schedule;Scientific Societies;Secure;sedative;Self Management;Services;Sleep;Sleep Disorders;sleep quality;Sleeplessness;Stimulus;success;Suicide prevention;symptom treatment;Symptoms;Technology;technology platform;telehealth;Testing;Therapeutic;Time;Training;Translating;Transportation;usability;user-friendly;Veterans

PROJECT_TITLE: SEdative-Hypnotic Deprescribing Assisted by a Technology-Driven Insomnia InterVEntion (SEDATIVE)

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Prevention;Suicide;Suicide Prevention

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: LEMURS (EXPLORATORY PROJECT): NARRATIVE See Project Narrative in the Overall component.

PI_NAMEs: BOUDREAUX, EDWIN D (contact)

PROGRAM_OFFICER_NAME: O'CONNOR, STEPHEN

PROJECT_TERMS: Acceleration;Address;Adherence;Adoption;aged;aging population;automated assessment;behavioral health;Businesses;Caring;Cause of Death;Cellular Phone;Clinic;college;Computer Models;contextual factors;dashboard;Data;Data Analyses;data modalities;data sharing;data streams;Decision Making;Depression screen;design;Development;Distress;economic evaluation;Economic Factors;Economics;Effectiveness;electronic health record system;Environment;Ethics;Evaluation;Evidence based practice;experience;Feasibility Studies;Feedback;Feeling suicidal;Focus Groups;Funding;General Population;Goals;Health;health care settings;Health Personnel;Health Professional;Health system;Health Technology;Healthcare;Healthcare Systems;implementation evaluation;implementation outcomes;implementation science;implementation study;indexing;Individual;innovation;Institution;interest;Intervention;Interview;Learning;Machine Learning;Measures;member;Mental Depression;Mental Health;mental health counseling;mHealth;Minority;Mobile Health Application;Monitor;Needs Assessment;novel;Participant;Patient Self-Report;Patients;performance site;Pilot Projects;preference;Privatization;Procedures;prototype;Provider;Reporting;Research;Research Personnel;Research Project Grants;Resources;Risk;Risk Management;routine screening;Sampling;screening;Self-Injurious Behavior;Severities;Site;Students;success;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide attempt;suicide model;Suicide prevention;Surveys;System;Technology;technology development;Testing;Text Messaging;tool;Translations;United States National Institutes of Health;university student;Update;uptake;usability;validation studies;Visit;Voice;willingness;Work

PROJECT_TITLE: Exploratory Research Project - LEMURS


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE The Never in mitosis A-related kinase (NEK) family of protein kinases is an important, yet understudied, kinase family that has recently been implicated in a variety of disorders, including numerous cancers, ciliopathies, chronic inflammatory diseases, and neuronal disorders. The lack of reliable tools to study NEK function has made it difficult to determine the specific role(s) that NEK family members play in the etiology and progression of these diseases. In the proposed project, we will use a generalizable, family-based strategy to develop a suite of tools, including high quality chemical probes, that will be made freely available to the biomedical researcher community and enable researchers to build a firm understanding of how these understudied kinases contribute to health and disease and validate new druggable targets for cancer drug discovery.

PI_NAMEs: BUROW, MATTHEW E.;DREWRY, DAVID HAROLD (contact);NEWMAN, ROBERT HOWARD

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: 3-Dimensional;Active Sites;Address;Antineoplastic Agents;Binding;Biological;Biological Assay;Biological Process;Biology;cancer therapy;Cell Cycle;Cell Cycle Regulation;Cell Line;cell motility;Cells;Cellular biology;Chemicals;chronic inflammatory disease;ciliopathy;cilium biogenesis;Communities;Data;design;Development;Diabetes Mellitus;Disadvantaged;Disease;Disease Progression;DNA biosynthesis;DNA Damage;drug development;drug discovery;drug quality;Drug Targeting;druggable target;Environment;Etiology;Family;Family member;FDA approved;Foundations;Free Will;Funding;Generations;Genome;Health;holistic approach;Human;Individual;Inflammation;Inflammatory Bowel Diseases;inhibitor;insight;kinase inhibitor;knock-down;Knock-out;Knowledge;lead optimization;Left;Link;Malignant Neoplasms;Measures;Medicine;member;migration;Mission;Mitosis;Modality;Molecular;Nature;Neurons;new therapeutic target;Oncology;Output;Pathologic;Pathway interactions;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phosphotransferases;Physiological;Play;Process;programs;Proliferating;Protein Family;Protein Kinase;Proteins;Proteome;Reagent;Reporter;Research;Research Personnel;Resources;response;RNA Splicing;Role;scaffold;Scientist;Signal Pathway;Signal Transduction;small molecule;success;System;Therapeutic;tool;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Identification and characterization of chemical probes for interrogation of the NEK family of kinases in cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Y(56)R]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: PROJECT NARRATIVE The tissue turnover and injury healing in murine teeth rely on proper homeostasis of mesenchymal stem cells (MSCs). This study will investigate how a predicted gene “Din” regulates MSCs homeostasis in murine teeth by modulating GTPases. Successful completion of this research will advance our understanding of the regulatory mechanism governing MSC homeostasis.

PI_NAMEs: WANG, XIAOFANG  (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: Aging;Ameloblasts;Binding Sites;Cell Cycle;Cell Lineage;Cell Proliferation;Cells;Cephalic;Computer Analysis;Defect;Dental;Dental Research;Dentistry;Down-Regulation;Epithelial Cells;epithelial stem cell;Epithelium;Genes;Growth;Guanosine Triphosphate Phosphohydrolases;healing;Homeostasis;Human;Impairment;Incisor;Injury;insight;Knock-out;Knockout Mice;Knowledge;lipid biosynthesis;Maintenance;Mesenchymal Stem Cells;migration;Modeling;Molecular;Motility;mouse model;Mus;Neural Crest;neutrophil cytosol factor 67K;novel;nuclear transport factor 2;Odontoblasts;Osteogenesis;overexpression;Pathway interactions;Pattern;Play;Process;Proliferating;Proteomics;regenerative;Regenerative capacity;Regenerative Medicine;Regulation;Research;response;rho GTP-Binding Proteins;Role;Series;Signal Pathway;Signal Transduction;single-cell RNA sequencing;stem cell homeostasis;stem cell niche;stem cells;stemness;Testing;tissue injury;tissue regeneration;Tissues;Tooth structure;transcriptomics;WNT Signaling Pathway

PROJECT_TITLE: A novel GTPase regulator governing the regenerative capacity of murine teeth

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Dietary Supplements;Osteoporosis

ORG_CITY: SAINT LOUIS

ORG_DEPT: ORTHOPEDICS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE Citrate is used by all aerobic organisms to produce usable chemical energy and is present in mineralized tissues (bone and teeth) at strikingly high concentrations. In this project, we will determine the mechanisms responsible for mineral citrate deposition in mice and men and the consequences of altered citrate handling by the osteoblast on tissue mineralization, citricemia and citruria, provoked by genetic mutations, pharmacologic interventions or in responds to endocrine cues. We believe our studies will validate a new metabolic pathway linking citrate metabolism to the biomechanical and physiological functions of mineralized tissues with the osteoblast as a central player.

PI_NAMEs: DIRCKX, NAOMI  (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Aerobic;Apatites;Biocompatible Materials;Biomechanics;Blood;bone;bone mass;bone quality;Bone remodeling;Bone Resorption;Calcium;Carbonates;career development;Cells;Cellular Metabolic Process;Chelating Agents;chelation;Chemicals;Circulation;citrate carrier;Citrates;Citric Acid Cycle;Collaborations;Collagen;Collagen Type I;Crystallization;Cues;deciduous tooth;Defect;Dental Enamel;Deposition;Development;Development Plans;Diabetes Mellitus;Diet;Disease;disease model;DNA Sequence Alteration;Down-Regulation;Drops;Endocrine;Equilibrium;extracellular;Family;fracture risk;Gatekeeping;genetic manipulation;Glucose;Goals;Homeostasis;Hormone Responsive;Hormones;Human;human disease;human induced pluripotent stem cells;improved;In Vitro;in vivo;insight;Institution;Intervention;Ions;Isotopes;Label;Link;mechanical properties;Mediating;member;Membrane;men;Mentorship;Metabolic;Metabolic Diseases;Metabolic Pathway;metabolic profile;Metabolism;mineralization;Minerals;Mitochondria;Modeling;mouse model;Mus;Mutation;nanocomposite;normal aging;novel;Organism;Osteoblasts;osteogenic;Osteoporosis;Pathologic;Patients;pharmacologic;Pharmacologic Substance;Physiologic calcification;Physiological;Physiology;prevent;Production;Productivity;Property;PTH gene;Radio;rare genetic disorder;Regulation;Renal clearance function;Research;Research Personnel;resilience;Resolution;response;Role;Scientist;Secondary to;Serum;Signal Transduction;skeletal;Skeleton;skills;Solid;solid state nuclear magnetic resonance;solute;Space Perception;Structure;success;symporter;Testing;Tissues;Tooth structure;training opportunity;uptake;urinary;usability

PROJECT_TITLE: Mechanisms and Impact of Osteoblast "Citration" on Skeletal Mineralization and Global Citrate Homeostasis

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Narrative This project aims to optimize transcranial magnetic stimulation (TMS) for the treatment of psychiatric disorders by using invasive electrophysiological recordings in non-human primates (NHPs). The research team plans to identify markers of TMS target engagement in the prefrontal cortex, characterize the effects of closed-loop TMS on brain responses, and evaluate the impact of closed-loop theta burst stimulation (TBS) on neural plasticity. Success in this project could lead to improved closed-loop TMS protocols with direct translational relevance to human applications in the treatment of psychiatric illnesses.

PI_NAMEs: FALCHIER, ARNAUD Y;OPITZ, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TERMS: Affect;biomarker identification;Brain;brain control;Brain region;Clinical;clinical practice;design;Development;Disease;Dose;Effectiveness;Electroencephalography;Electrophysiology (science);Evoked Potentials;FDA approved;Frequencies;Future;Generations;Human;improved;Individual;interest;Measurement;Measures;Mental Depression;Mental disorders;Methods;Modeling;multisensory;neural;Neuronal Plasticity;Neurons;Noise;nonhuman primate;Outcome;Participant;Patients;Pharmaceutical Preparations;Phase;Physiologic pulse;Physiological;Prefrontal Cortex;Protocols documentation;Psychiatric therapeutic procedure;repetitive transcranial magnetic stimulation;Research;Resistance;Resolution;response;Scalp structure;Signal Transduction;somatosensory;Source;spatiotemporal;Specific qualifier value;success;System;Technology;Theta Rhythm;Time;Transcranial magnetic stimulation;Translating;Translations;Validation;Work

PROJECT_TITLE: Validation of Closed-Loop Prefrontal Transcranial Magnetic Stimulation in a Non-Human Primate Model

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-Q (91)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Nutrition

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE At any given time, humans are infected with multiple pathogens. The interaction of more than one pathogen in an infected host is poorly understood, because most experimental systems focus on single infections with individual pathogens. This work will examine how co-infections with a gammaherpesvirus and an intestinal parasite are different than single infections in mice.

PI_NAMEs: REESE, TIFFANY ANNE (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Acids;Address;Animals;Biology;Bone Marrow;Breeding;Cell Physiology;chronic infection;co-infection;cytokine;Data;Deposition;Diet;dietary;Distal;embryonic stem cell;Epigenetic Process;gammaherpesvirus;Genome;Goals;Grant;helminth infection;Helminths;Herpesviridae;Herpesviridae Infections;Histones;Human;Immune;Immune response;Immune system;immunoregulation;Individual;Infection;insight;Interleukin-4;Intestinal parasite;Intestines;Macrophage;Maintenance;Modification;mouse model;Mus;Nematospiroides dubius;Parasites;Parasitic infection;pathogen;Peritoneal;Peritoneal Macrophages;Peritoneum;Persons;Phenotype;Population;progenitor;reactivation from latency;Reporting;response;Role;Science;Signal Transduction;System;Time;Tissues;Tretinoin;Viral Genome;virtual;Virus;Virus Activation;Virus Diseases;Virus Latency;Vitamin A;Vitamin A Deficiency;Work

PROJECT_TITLE: Defining Mechanisms for Parasite-Driven Effects on Gamma-Herpesvirus Latency

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE Mycobacterium avium is an environmental bacterium that is capable of infecting humans and causing serious disease, requiring months to years of antibiotic treatment to cure. This proposal aims to use novel genetic tools to identify the bacterial genes that allow some strains of M. avium to establish chronic infection, and the pathways that allow M. avium to tolerate prolonged antibiotic exposure once infection is established. In doing so, this work will provide fundamental insights into how environmental bacteria evolve into pathogens, and lay a foundation for the development of improved therapies for this and other chronic bacterial infections.

PI_NAMEs: CAREY, ALLISON  (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Acute;Address;Antibiotic Therapy;antibiotic tolerance;Antibiotics;antimicrobial;Bacteria;bacterial fitness;Bacterial Genes;Bacterial Genome;Bacterial Infections;Bar Codes;Biodiversity;Bioinformatics;Biological;Catalogs;Characteristics;Chronic;chronic infection;Clinical;clinically relevant;Communicable Diseases;comparative genomics;Creativeness;Data;design;Development;Diagnostic;Disease;disease phenotype;drug efficacy;Drug Exposure;emerging antimicrobial resistance;emerging pathogen;Environment;Experimental Genetics;experimental study;fitness;Foundations;Genes;Genetic;Genetic Determinism;Genetic Variation;genome wide association study;Genomic approach;Genomics;Genotype;Heterogeneity;Human;Impairment;improved;In Vitro;in vivo;Incidence;Infection;insight;interest;Link;Maps;Measurement;Methods;Microbe;microbial;Molecular;Morbidity - disease rate;mouse model;Mus;Mutation;mycobacterial;Mycobacterium avium;Mycobacterium tuberculosis;novel;novel strategies;Opportunistic Infections;Organism;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Phenotype;phenotypic data;Postdoctoral Fellow;Predisposition;programs;public health intervention;Research;response;skills;Techniques;Technology;Testing;Therapeutic;therapeutically effective;tool;trait;Treatment outcome;treatment response;Vaccination;vaccine efficacy;Vaccines;Virulence;Work

PROJECT_TITLE: Parallel phenotyping to dissect genetic determinants of bacterial strain diversity


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biotechnology;Brain Disorders;Cannabinoid Research;Conditions Affecting the Embryonic and Fetal Periods;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Substance Misuse

ORG_DEPT: PHYSIOLOGY

PHR: Project Narrative The goal of this work is to increase our understanding of the pathogenic mechanisms underlying Fetal Alcohol Spectrum Disorders, especially those involving key developmental signaling and cellular pathways in order to aid in prevention and intervention efforts. We will use genomic, proteomic, and chemical interactions in mice and in vitro cell culture to discover novel mechanistic pathways of early gestational ethanol exposure.

PI_NAMEs: PARNELL, SCOTT  (contact);WILLIAMS, KEVIN PETER

PROGRAM_OFFICER_NAME: DUNTY, JR, WILLIAM

PROJECT_TERMS: addiction;Address;Adult;Affect;alcohol effect;alcohol exposure;alcohol testing;Alcohols;Anterior;Apoptosis;Area;Biological Models;Brain;brain abnormalities;Candidate Disease Gene;Cannabinoids;Cell Culture Techniques;Cells;Cellular biology;Central Nervous System;Chemicals;Cilia;ciliopathy;Classification;Clinical Research;CNR1 gene;Congenital Abnormality;Craniofacial Abnormalities;craniofacial development;Defect;design;Development;Developmental Process;Embryo;Embryonic Development;endogenous cannabinoid system;Ethanol;Event;experimental study;Exposure to;Face;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fetal Alcohol Syndrome;Functional disorder;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;gastrulation;Genes;Genetic;genetic analysis;Genomics;Goals;Hair;high throughput screening;Holoprosencephaly;Homeostasis;human disease;Hypothalamic structure;In Vitro;in vitro Assay;in vivo;Induction of Apoptosis;innovation;interdisciplinary approach;Intervention;Knowledge;Liver;Malignant Neoplasms;Mediating;Mediator;Microtubules;Mitotic Cell Cycle;Molecular Biology;Mus;neural plate;Neural tube;Neural Tube Development;novel;Organelles;Pathogenicity;Pathway interactions;Pregnancy;Prevention;Prevention strategy;Process;Protein translocation;Proteins;Proteomics;receptor;Research;Research Design;research study;Role;Septal Area;Series;SHH gene;Signal Pathway;Signal Transduction;small molecule;small molecule libraries;smoothened signaling pathway;Sonic Hedgehog Pathway;Structure;Techniques;Teratogenic effects;Testing;tool;transcriptomics;Transgenic Mice;Work

PROJECT_TITLE: Cellular Mechanisms in Fetal Alcohol Spectrum Disorders

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Herpesviruses are important human pathogens that can have devastating effects in neonates and immunocompromised individuals, yet there is no cure for any herpesvirus and treatment options are lacking. Here, I dissect the mechanism of an essential feature of the herpesviral lifecycle - viral genome packaging - by exploring the role of a unique accessory factor required for packaging and by developing an assay to monitor packaging in vitro. Detailed mechanistic insight is essential to understand the mechanism of current antiherpesviral drugs and to facilitate the identification of new targets for antivirals.

PI_NAMEs: DIDYCHUK, ALLISON LOUISE (contact)

PROJECT_TERMS: Address;Adopted;Africa South of the Sahara;Anti-viral Agents;Area;Award;Bacteriophages;Behavior;Biochemical;Biochemistry;Biological Assay;Biology;biophysical properties;Biophysics;Cancer Etiology;Capsid;Charge;Complex;Congenital Abnormality;Coupled;Development;Disease;Dissection;DNA Viruses;drug discovery;Drug Targeting;Evolution;FDA approved;Foundations;Genome;Goals;Herpes encephalitis;Herpes Labialis;Herpesviridae;High Prevalence;high reward;high risk;HIV;Homologous Gene;Human;Human Herpesvirus 8;human pathogen;Immunocompromised Host;In Vitro;in vivo;Individual;Infection;inhibitor;insight;interest;Investments;Kaposi Sarcoma;Label;Life;Life Cycle Stages;Malignant Neoplasms;Mass Spectrum Analysis;Methodology;Methods;Microscopy;Molecular;Molecular Motors;Molecular Virology;Monitor;Motor;Mutagenesis;mutation screening;neonate;new therapeutic target;novel;Nucleic Acid Binding;Oncogenic;pathogen;Pharmaceutical Preparations;Positioning Attribute;Process;programs;Proteins;Proteomics;reconstitution;Regulation;Research Personnel;resistance mutation;Resources;Role;scaffold;structural biology;Structure;success;System;Tail;Techniques;terminase;Testing;Time;Viral;Viral Genome;Viral Packaging;Viral Proteins;virology;Virus;Virus Replication;Vision;Work

PROJECT_TITLE: Dissecting the mechanism of herpesvirus genome packaging


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Cooley's Anemia;Hematology;Nutrition;Pediatric;Pregnancy;Rare Diseases;Women's Health Research

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Advances in the treatment of β-thalassemia have allowed patients with this disease to conceive and bear children; however, these pregnancies are associated with increased risk of adverse pathophysiological outcomes in mothers and babies. Anemia, hypoxia, and iron overload with increased oxidative stress typify β-thalassemia. We will use pre-clinical mouse models to define how iron overload/oxidative stress and anemia/hypoxia affect maternal and fetal outcomes in thalassemic pregnancy and will also test new treatments to lower maternal plasma iron levels to mitigate fetal iron loading and prevent development of iron overload- and oxidative stress-related pathologies.

PI_NAMEs: COLLINS, JAMES F. (contact);NEMETH, ELIZABETA

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: absorption;Affect;Anemia;Antioxidants;Area;beta Thalassemia;Bioluminescence;Blood Transfusion;Brain;Cardiovascular system;child bearing;Clinical;Clinical Treatment;comparison group;Complex;Consumption;Control Groups;Data;Development;Diet;Disease;DNA;effective intervention;end stage disease;Energy Metabolism;Epigenetic Process;Equilibrium;Erythropoiesis;experimental analysis;experimental study;Exposure to;fetal;Fetal Growth Retardation;Fetal Liver;Fetal Tissues;Fetus;fetus hypoxia;Future;Goals;Growth;healthy pregnancy;Heme Iron;hepcidin;high risk;Homeostasis;Hormones;Human;Hypoxia;improved outcome;in utero;in vivo;Infusion procedures;insight;Intervention;Intestines;Investigation;Iron;iron absorption;Iron Metabolism Disorders;Iron Overload;Iron-Regulatory Proteins;Kidney;Knowledge;Label;Lead;Liver;Mediating;Metabolic;Metabolism;mimetics;Modeling;Molecular;Molecular Analysis;Morbidity - disease rate;mortality;Mothers;mouse model;Mus;Mutation;nanoparticle delivery;neonate;novel;novel therapeutic intervention;offspring;Organ;Outcome;Oxidation-Reduction;Oxidative Stress;Oxygen;Pathologic;Pathology;Pathway interactions;Patients;Phenotype;Physiological;Pilot Projects;Placenta;placental transfer;Plasma;Play;postnatal;postnatal development;pre-clinical;Pre-Clinical Model;Pregnancy;prevent;Process;Production;pup;Reporter;response;Risk;Role;Serum;SLC11A2 gene;Small Interfering RNA;SOD2 gene;Source;synergism;Testing;Thalassemia;Tissues;Transfusion

PROJECT_TITLE: Pathological consequences of iron excess and hypoxia in β-thalassemia pregnancy

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: PROJECT NARRATIVE Recent increased rates of overdose deaths involving opioids and xylazine are quickly becoming a major public health problem, exacerbating the opioid crisis which was already worsening in the wake of the COVID-19 pandemic and increased availability of fentanyl. There are little/no data on why opioid/xylazine mixtures are used, the nature of interactions between opioids and xylazine, or potential treatments. Proposed studies use well-established methods and a highly translational species to improve our understanding of interactions between opioids and xylazine as well as to elucidate factors contributing to the use of opioid/xylazine mixtures, which will help to drive the discovery of safe and effective treatments.

PI_NAMEs: MAGUIRE, DAVID RICHARD (contact)

PROJECT_TERMS: abuse liability;Address;Adrenergic Agonists;Adrenergic Antagonists;Adverse effects;Agonist;Analgesics;analog;Authorization documentation;behavioral pharmacology;Bradycardia;Caring;Clonidine;Coma;Combined Modality Therapy;COVID-19 pandemic;Data;Dopamine;Drowsiness;effective therapy;Effectiveness;Exposure to;FDA approved;Fentanyl;fentanyl use;heroin use;Human;Hypotension;improved;Knowledge;Measures;Methods;Motivation;Muscle relaxants;Naloxone;natural hypothermia;Nature;Necrosis;non-opioid analgesic;nonhuman primate;Norepinephrine;Opiate Addiction;Opioid;opioid abuse;opioid epidemic;opioid overdose;opioid withdrawal;Overdose;overdose death;Pharmaceutical Preparations;Physical Dependence;Plethysmography;Procedures;Property;Public Health;Receptors, Adrenergic, alpha-2;Reporting;Risk;sedative;Self Administration;Severities;skin lesion;soft tissue;Stimulus;Testing;United States;ventilation;Ventilatory Depression;Withdrawal;Xylazine

PROJECT_TITLE: Behavioral Pharmacology of Opioid/Xylazine Mixtures

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because of the ongoing rise in opioid overdose deaths across urban and rural communities and the known racial and geographic inequities in access to medications for opioid use disorder. Increasing the receipt of and equity in services across the opioid treatment cascade to reduce opioid harms is a priority of the National Institute on Drug Abuse. Leveraging data science to better localize and monitor responses for OUD treatment by developing a replicable and scalable Small Area Multidimensional suite of measures of medication access will inform organizational-, community-, and system- level interventions to improve receipt of services across the opioid treatment cascade.

PI_NAMEs: JOUDREY, PAUL J (contact);KOLAK, MARYNIA

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: access disparities;Affect;Age;age related;American;Area;beneficiary;Buprenorphine;Censuses;Centers for Disease Control and Prevention (U.S.);Characteristics;Clinic;Collaborations;Communities;community partners;Community Surveys;County;dashboard;Data;Data Science;Data Set;Decision Analysis;Development;dimension reduction;Dimensions;District of Columbia;Drug user;Environment;Equity;Ethnic Origin;Funding;Gender;Generations;geographic disparity;Geography;Goals;Harm Reduction;Health;health care availability;health care service;Healthcare;improved;indexing;Individual;innovation;insight;Insurance;Intervention;Interview;Link;Location;Measures;Medicaid;medication for opioid use disorder;Methadone;Methods;Modeling;Monitor;multilevel analysis;Naltrexone;National Institute of Drug Abuse;Opioid;opioid mortality;opioid use disorder;Outcome;overdose death;Overdose reduction;patient oriented;Pharmaceutical Preparations;Public Health;Race;racial disparity;Research;Resources;response;Risk;Rural Community;service organization;Services;social stigma;social vulnerability;structural health determinants;Structure;Surveys;System;Techniques;Time;United States Health Resources and Services Administration;Urban Community;US State;Variant

PROJECT_TITLE: Localize Opioid Use Disorder (LOUD) response to increase medication access

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]