NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Immunotherapy;Nanotechnology;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_NAME: DUO ONCOLOGY INC

PHR: Project Narrative: Pancreatic cancer is one of the deadliest solid tumor malignancies. With DUO-307, Duo Oncology combines a chemotherapeutic and an immunomodulatory agent to kill cancer cells and stimulate the body’s immune response to recognize and kill the cancer. This therapy is delivered as an ultrasmall nanomedicine that can penetrate the dense stroma tissue surrounding the tumor.

PI_NAMEs: EICHINGER, KATHERINE MARIE (contact)

PROGRAM_OFFICER_NAME: POND, MONIQUE ADRIANNE

PROJECT_TERMS: Advocacy;antagonist;Antibodies;Apoptosis;Biological Assay;Biotechnology;Blood Cell Count;cancer cell;Cancer Prognosis;CCL2 gene;Cell Therapy;Cessation of life;checkpoint therapy;Chemical Engineering;chemokine;chemokine receptor;Chemotaxis;Clinical Chemistry;Clinical Pharmacists;Clinical Trials;Collaborations;commercialization;cytotoxic;design;Doctor of Philosophy;Dose;efficacy testing;Exclusion;experience;Exposure to;Formulation;Funding;gemcitabine;General Hospitals;graduate school;Grant;Harvest;Healthcare;Human;Immune checkpoint inhibitor;immune modulating agents;Immune response;Immuno-Chemotherapy;Immunotherapy;Implant;Industry;innovation;Institution;interest;Investments;KRASG12D;Laboratories;Lead;Ligands;Malignant neoplasm of pancreas;Malignant Neoplasms;manufacture;Massachusetts;Maximum Tolerated Dose;Medical Oncologist;member;monocyte;mouse model;Mus;nanomedicine;nanoparticle;novel;Oncology;operation;Organ;pancreatic cancer model;pancreatic cancer patients;pancreatic neoplasm;pancreatic PDX models;particle;Particle Size;patient derived xenograft model;Patients;Penetration;Pharmaceutical Preparations;Pharmacologic Substance;Phenotype;Population;pre-clinical;primary outcome;Privatization;Prodrugs;Production;programs;Qualifying;receptor;research clinical testing;response;Role;Safety;Sampling;Schedule;Science;Secure;Shapes;Small Business Technology Transfer Research;small molecule;Solid Neoplasm;synergism;System;Therapeutic;Time;Tissue Sample;Tissues;Toxicology;tumor;tumor growth;Tumor Immunity;Tumor Tissue;Tumor-associated macrophages;tumor-immune system interactions;Universities;Vascularization;Work

PROJECT_TITLE: A novel dual-carrier ultrasmall nanomedicine for the treatment of stroma-rich pancreatic cancer


ADMINISTERING_IC: MH

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Mental Illness;Neurosciences;Opioids

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

ORG_STATE: NY

PHR: Project Narrative Millions of Americans suffer from deficits in reward processing in the context of psychiatric disorders, such as major depressive disorder and schizophrenia. The endogenous opioid system plays a key role in reward processing. In this project, we will test whether administering a novel compound that increases endogenous enkephalin levels can reverse reward processing deficits without raising the risk of substance use disorders.

PI_NAMEs: HARRIS, ALEXANDER  (contact);PINTAR, JOHN E

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: abuse liability;Acute;addiction;American;Anhedonia;antagonist;anti-depressive agents;Behavior;behavior change;Binding;Biological Assay;Categories;Chronic;Chronic stress;Clinical;Communication;conditioned place preference;Data;delta opioid receptor;ecstasy;endogenous opioids;Enkephalin Receptors;Enkephalins;experimental study;Female;Functional disorder;Future;gamma-Aminobutyric Acid;hedonic;improved;in vivo;Infusion procedures;inhibitor;Injections;insight;Knock-out;Knockout Mice;Major Depressive Disorder;male;Measures;Mediating;Mental disorders;Motivation;mu opioid receptors;Mus;Mutation;Neprilysin;neural;Neurons;Neurotransmitters;novel;Nucleus Accumbens;Opioid;Opioid agonist;Opioid Antagonist;Opioid Peptide;Opioid Receptor;Outcome;patient subsets;Patients;Play;preference;prevent;Process;psychiatric symptom;receptor;response;reward circuitry;reward processing;Rewards;Risk;Role;Schizophrenia;Selective Serotonin Reuptake Inhibitor;Serotonin;side effect;Signal Transduction;Site;social defeat;Stress;Substance Use Disorder;symptom treatment;Symptoms;System;Testing;Therapeutic Agents;Ventral Tegmental Area;Water

PROJECT_TITLE: Modulating Endogenous Opiate Signaling to Reverse Stress-Induced Deficits in Reward Processing

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Project Narrative The overall goal of this research is to examine the psychosocial, ethical, and clinical implications of unexpected medical findings in healthy adult volunteer stem cell donors – the proposed project focuses on demonstrating our ability to collect these data. We will (1) conduct focus groups with past donors who have no unexpected medical findings and (2) conduct telephone interviews with, and collect biological samples from, donors who have received unexpected medical findings. Results from this study will lead directly to a larger investigation of unexpected medical findings in this healthy donor group, which will have implications for a broad range of healthy and ill individuals with such findings.

PI_NAMEs: SWITZER, GALEN E.;TAMARI, RONI  (contact)

PROGRAM_OFFICER_NAME: CAGA-ANAN, EMILIE CHARLISSE F

PROJECT_TERMS: Adult;adverse outcome;Awareness;Biological;Blood;Blood specimen;Calcium;cardiovascular disorder risk;cardiovascular risk factor;Clinical;Clinical Data;Clinical Markers;cohort;Communication;Data;Diagnosis;Disease;DNA;donor stem cell;egg;Enrollment;Ethics;Feasibility Studies;Feces;Focus Groups;follow-up;Frequencies;Germ Cells;Germ-Line Mutation;Goals;Health;Health behavior;health related quality of life;healthy volunteer;Hematologic Neoplasms;Hematopoiesis;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Incidental Findings;Individual;Inflammatory;innovation;Interview;Investigation;Lead;lifestyle factors;Link;Marrow;Medical;Mutation;Natural History;Notification;offspring;Outcome;Participant;participant interview;Patients;Perception;Persons;Population;preference;Preparation;Process;programs;prospective;psychosocial;Psychosocial Assessment and Care;Psychosocial Influences;Recommendation;Registries;Research;Resources;Risk;Sampling;Schedule;screening;Series;Somatic Mutation;sperm cell;Stem cell transplant;stool sample;Structure;Survival Rate;Telephone Interviews;Testing;volunteer

PROJECT_TITLE: Incidental diagnosis of clonal hematopoiesis among healthy, unrelated, hematopoietic stem cell donors: A feasibility study of psychosocial, ethical, and clinical issues

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SEIR-P (80)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Opioid Misuse and Addiction;Opioids;Pediatric;Pregnancy;Prevention;Primary Health Care;Recovery Support Services;Rural Health;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: Pittsburgh

ORG_NAME: MAGEE-WOMEN'S RES INST AND FOUNDATION

ORG_STATE: PA

PHR: Opioid use disorder (OUD) during pregnancy is a major contributor to maternal morbidity and mortality in the United States, and particularly in rural and low-resource obstetric settings. Collaborative care approaches to substance use treatment – which are designed to comprehensively treat the social, behavioral, and physical health needs of patients – have emerged as a way to address the complex needs of pregnant, postpartum, and parenting persons with OUD. This research project will adapt an innovative comprehensive care model for low- resource obstetric settings and will test the implementation and effects of the care model on maternal, infant, and family health outcomes.

PI_NAMEs: JARLENSKI, MARIAN PATRICIA;KRANS, ELIZABETH E (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: Academic Medical Centers;Address;Affect;Appalachian Region;barrier to care;behavioral health;Buprenorphine;Capital;Caring;Cessation of life;Child;Child Rearing;child services;Clinical;Coercion;collaborative care;Communities;community based care;comorbidity;Complex;Comprehensive Health Care;Data Collection;data modeling;Data Reporting;Data Sources;data structure;design;Diagnosis;Dimensions;Discipline of obstetrics;Drug usage;Effectiveness;effectiveness/implementation study;Evaluation;Excision;experience;Face;Family;Family health status;foster care;Gender;Goals;Harm Reduction;Health;health care settings;Health Personnel;Healthcare;implementation framework;improved;improved outcome;Individual;Infant Health;innovation;Intervention;Interview;Location;Maternal Health;maternal morbidity;Maternal Mortality;Mediating;Mediation;Medicaid;medication for opioid use disorder;Mental Health;Methadone;Methods;model design;Modeling;Modification;Morbidity - disease rate;multidisciplinary;Opioid;opioid epidemic;opioid use disorder;Outcome;Outpatients;Overdose;overdose risk;patient subsets;Patients;peer;peer support;Pennsylvania;person centered;Persons;Phase;physical conditioning;Policy Maker;postpartum outcome;Postpartum Period;Pregnancy;pregnant;Premature Birth;Process;Provider;Recommendation;Recovery;recovery community organization;Recovery Support;Research;Research Project Grants;Resource-limited setting;Resources;return to use;Risk;Risk Reduction;Rural;rural healthcare;rural setting;Self Efficacy;service delivery;service utilization;Services;Site;social;social health determinants;social service provider;substance use;substance use treatment;tertiary care;Testing;Trauma;United States;violence exposure;Woman

PROJECT_TITLE: Impact of collaborative care for pregnant persons with opioid use disorder in low-resource obstetric settings

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SKP-E (M2)]


ADMINISTERING_IC: AG

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Health Services;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Rehabilitation;Telehealth

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative Recent research has shown that hand grip strength (HGS), an index linked to systemic physiological frailty and all-cause mortality, may provide a new biomarker of risk assessment of surgical readiness and potential of postoperative complication; diminutive preoperative HGS indicates a heightened risk of postsurgical complication. This project aims to develop a self-administrable dynamometer for older adults that uses a smartphone’s built-in vibration motor and sensor to record HGS, with the goal of enabling a machine learning- based risk prediction prior to admission day-of-surgery. An automated phone-sensor based surgical outcomes prediction tool has the power to enable remote monitoring to guide preoperative care through adapting prehabilitation protocol and timely intervention for unexpected health status changes needed for maximizing surgical preparedness.

PI_NAMEs: WANG, EDWARD JAY (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Ablation;Accelerometer;Admission activity;Algorithms;Anesthesiology;Biological Markers;Cardiac Surgery procedures;Cardiopulmonary;Cellular Phone;Clinic;Clinic Visits;Clinical;clinical practice;cohort;Complex;Complication;cost;Data;Data Set;Day Surgery;Death Rate;demographics;design;Deterioration;Devices;Diet;digital;Digital biomarker;early detection biomarkers;Early Intervention;Effectiveness;electronic health record system;Exercise;Feedback;fitness;Foundations;frailty;Future;Goals;grasp;Habilitation;Hand;Hand functions;Hand Strength;Health Status;Healthcare Systems;high risk;Home;hospital readmission;improved;Incentives;indexing;Individual;Informatics;insight;Intervention;Length of Stay;Link;Location;Machine Learning;machine learning algorithm;machine learning model;machine learning prediction;Manuals;Measurement;Measures;Mechanical ventilation;medical schools;Mental Health;Methods;Modernization;Monitor;Morbidity - disease rate;mortality;Motor;Nature;novel;older adult;operation;Operative Surgical Procedures;Outcome;Patient Discharge;Patients;Perioperative;Perioperative Care;Persons;Physiological;Population;Postoperative Complications;Postoperative Period;predictive tools;Preoperative Care;Procedures;Protocols documentation;Quality of Care;Readiness;Recovery;recruit;remote monitoring;Research;Risk;Risk Assessment;Risk Factors;risk prediction;risk stratification;screening;Self Administration;sensor;smartphone application;success;surgery outcome;Surgical complication;surgical risk;System;systemic inflammatory response;Taxes;Techniques;Technology;Telephone;Time;Training;translational goal;Translations;Update;vibration

PROJECT_TITLE: Preoperative Risk Prediction of Postoperative Complications for Elective Cardiac Surgery using At-home Smartphone Dynamometry

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Lung;Neurosciences;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Sleep Research;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_NAME: ALTRUMED LLC

PHR: NARRATIVE Overdose with opioids (drugs similar to morphine, such as heroin) causes subjects to stop breathing enough and suffocate. An antidote to opioid overdose, naloxone, is widely distributed, but it requires a bystander to identify a person overdosing, obtain naloxone, and inject it properly; all within < 5 minutes to prevent brain damage, and somewhat longer to prevent death. Therefore, we have invented the DOVE device, which is an armband that detects opioid overdose and automatically injects the antidote, and we will further develop and test it here.

PI_NAMEs: BRENNER, JACOB  (contact)

PROGRAM_OFFICER_NAME: ANGELONE, LEONARDO MARIA

PROJECT_TERMS: Academia;Accelerometer;Antidotes;Asphyxia;Brain Injuries;Breathing;Cadaver;Cessation of life;Collaborations;deltoid muscle;Device Designs;Devices;Diagnosis;Epidemic;Event;Family suidae;Fatty acid glycerol esters;FDA approved;Freedom;Grant;healthy volunteer;Heroin;Hypoventilation;Hypoxemia;Hypoxia;Industry;Interview;invention;Marketing;Modeling;Morphine;Muscle;Naloxone;Obstructive Sleep Apnea;Opioid;opioid mortality;opioid overdose;opioid user;Overdose;Paper;Patients;Persons;Pharmaceutical Preparations;Physiologic pulse;Positioning Attribute;preference;prevent;Probability;prototype;Publishing;Pulse Oximetry;Reproducibility;Ring Finger Domain;Sales;sensor;Shapes;Shoulder;Skin;Sleep;Small Business Technology Transfer Research;Specific qualifier value;Structure;Technology;Testing

PROJECT_TITLE: The DOVE Device to Prevent Opioid Overdose Deaths: An Armband That Senses Overdose and Automatically Injects Naloxone


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: NEUROSURGERY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Myelin is essential for rapid nerve signaling and its loss in diseases like multiple sclerosis or after injury causes severe disability in patients. We propose to harness innovative tools and methods we developed to increase our fundamental understanding of how myelin forms normally during vertebrate central nervous system development, using both in vivo and primary cell culture approaches. These studies will contribute knowledge toward our ultimate goal of promoting remyelination in patients to reduce the burden of neurological diseases.

PI_NAMEs: ZUCHERO, JOHN B (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Actins;Axon;cell motility;Central Nervous System;Chronic;Cytoskeleton;Data;disability;Disease;Foundations;Future;Genetic;Goals;Growth Cones;Impairment;in vivo;Injury;innovation;Knowledge;live cell imaging;Membrane;Methods;Microfilaments;Microscopy;Modeling;Multiple Sclerosis;Multiple Sclerosis Lesions;Myelin;myelination;nervous system development;Nervous System Disorder;neuronal growth;Neurons;neurotransmission;Oligodendroglia;Patients;Primary Cell Cultures;Process;remyelination;Research;Role;Techniques;Testing;tool;translational study;Vertebrates

PROJECT_TITLE: How Does Actin Disassembly Drive Myelin Wrapping?


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE There is currently no therapy that can prevent the development of epilepsy after brain trauma. Here we propose to test the efficacy of a novel compound, and determine its efficacy and tolerability in an animal model of posttraumatic epilepsy, in a setting that resembles the clinical practice of care of people with severe traumatic brain injury. We also aim to identify and validate novel biomarkers that can predict who will develop epilepsy and who may respond to a treatment that can prevent epilepsy, in hope that this may accelerate and optimize future efforts to develop new antiepileptogenic therapies.

PI_NAMEs: AGOSTON, DENES V.;COLES, LISA D;DUNCAN, DOMINIQUE ;GALANOPOULOU, ARISTEA S (contact);MAZARATI, ANDREY M;O'BRIEN, TERENCE JOHN;STABA, RICHARD

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Acceleration;acquired epilepsy;Acute;Advisory Committees;Advocate;Anatomy;Animal Model;Anticonvulsants;Antiepileptogenic;Autophagocytosis;Axon;Bioinformatics;Biological Markers;biomarker discovery;biomarker identification;biomarker panel;biomarker selection;Blood;Blood Vessels;Brain;brain magnetic resonance imaging;Brain Pathology;Calcium-Binding Proteins;California;candidate marker;Caring;Cell Death;Cessation of life;Classification;Clinical;clinical practice;Collaborations;college;Corpus Callosum;Data;Deposition;design;Development;Discriminant Analysis;Disease;Double-Blind Method;early detection biomarkers;Early Post-Traumatic Seizures;Early treatment;efficacy testing;Electroencephalography;Epilepsy;Epileptogenesis;experience;External Capsule;fluid percussion injury;Free Radicals;functional outcomes;Funding;Future;Glial Fibrillary Acidic Protein;Guidelines;Health Services;Hemorrhage;High Frequency Oscillation;high standard;histological stains;HMGB1 gene;Image;improved;in vivo;Inflammatory;Injury;Interferon Type II;Interleukin-1 beta;International;Intervention;Investigation;Iron;Iron Chelation;Isoenzymes;Laboratories;Lateral;Learning;Levetiracetam;Link;Machine Learning;Magnetic Resonance Imaging;Medicine;Memory;Metabolic;Minnesota;Modeling;Modification;Molecular;Monitor;Motor;multimodality;National Institute of Neurological Disorders and Stroke;Neuroglia;neuroimaging;Neurons;novel;novel marker;Oxidative Stress;Pathologic;Pathology;Patients;Peripheral;Persons;pharmacokinetic model;Physiological;Plasma;Populations at Risk;Post-Traumatic Epilepsy;pre-clinical;Pre-Clinical Model;Preclinical Testing;predictive marker;Predictive Value;prevent;primary endpoint;Process;prophylactic;protein biomarkers;Randomized;Rattus;Recovery of Function;Research;Risk;Risk Factors;Seizures;Site;standard of care;synergism;tau Proteins;tau-1;Testing;Therapeutic;Time;Tissues;Translational Research;Traumatic Brain Injury;treatment response;ubiquitin C-terminal hydrolase;Universities;University Health Services;Visuospatial

PROJECT_TITLE: Translational Platform for Epilepsy Therapy and Biomarker Discovery


PHR: The desmoplastic small round cell tumor (DSRCT) remains one of the most lethal adolescent/young adult (AYA) sarcomas. The EWSR1-WT1 gene fusion is the primary and defining genetic driver alteration in this sarcoma but a better understanding of EWSR1-WT1 oncogenic mechanisms is needed to identify novel, rational therapeutic strategies that will be more effective. We propose to address these knowledge gaps by establishing the first genetically engineered mouse model of DSRCT and to define its pathobiology more fully by harnessing two recent novel observations in DSRCT, namely induction of neotranscripts and recurrent ARID1A loss as a frequent additional genetic alteration in these cancers.

PI_NAMEs: LADANYI, MARC  (contact);VENTURA, ANDREA

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Address;Adenovirus Vector;Adolescent;Alleles;ARID1A gene;Biological Models;Catalogs;cell type;Chemicals;Chimeric Proteins;Clinical;Cloning;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;cohort;Complex;Desmoplastic Small Round Cell Tumor;Development;Dicentric chromosome;Doxycycline;Engineering;Epigenetic Process;Ewings sarcoma;EWSR1 gene;FLI1 gene;functional genomics;Gene Expression Regulation;Gene Fusion;Genes;Genetic;Genetic Transcription;Genetically Engineered Mouse;Genomics;Germ Lines;Growth;Guide RNA;Human;in vivo;Individual;insight;kinase inhibitor;Knowledge;Laboratories;Link;Malignant - descriptor;Malignant Neoplasms;Mediating;Memorial Sloan-Kettering Cancer Center;Methods;Modeling;Molecular;mouse genome;mouse model;Mouse Strains;Mus;Mutate;Mutation;neoantigens;Newborn Infant;novel;Oncogenic;patient derived xenograft model;Patients;Pattern;Phenotype;Phosphotransferases;Play;Poly A;Poly(A)+ RNA;preclinical evaluation;prospective;Proteins;Recombinants;Recurrence;Regulation;Reporting;response;Rhabdoid Tumor;Role;Sarcoma;Signal Transduction;SMARCB1 gene;Solid;somatic cell gene editing;Somatic Mutation;Testing;Therapeutic;therapeutic target;Tissues;TP53 gene;transcription factor;Transgenic Mice;Translating;Translocation Breakpoint;tumor;Tumor Biology;Tumor Cell Biology;Tumor Cell Line;tumor initiation;tumor progression;WT1 gene;young adult

PROJECT_TITLE: Desmoplastic small round cell tumor: harnessing new insights and new models

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-P (M2)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: COLUMBIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative The recent development of [11C]ORM13070, a PET radioligand for 2C-adrenergic receptors (ARs), became a milestone for the development of subtype-specific drugs and radioligands for ARs, whose nonspecific drugs are consumed every day by middle-aged or older population worldwide to prevent cardiovascular emergencies and to manage their blood pressure, as strategies for reducing the dangerous cardiac and neuronal side effects of the nonspecific drugs for ARs. The localized distribution of 2C-ARs in the limbic regions of the brain and their presynaptic function as autoreceptors and heteroreceptors, which regulate the levels of norepinephrine, dopamine, and serotonin in the synapse, motivated us to develop more practical and useful F-18 PET radiotracers for 2C-ARs based on [11C]ORM13070 and to monitor the receptors in viable states to help set up the therapeutic strategy for 2C-ARs. This proposal will use a stepwise approach to synthesize seven 1,4- benzodioxane derivatives followed by receptor-binding assays for the in vitro screening, and the selected compounds will be prepared as F-18 radiotracers for preclinical PET imaging studies and autoradiography, which will be compared to immunohistochemistry work to validate the PET imaging data.

PI_NAMEs: KIL, KUN-EEK  (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Adrenergic Agents;Adrenergic Agonists;Adrenergic alpha-Antagonists;Adrenergic beta-Antagonists;Adrenergic Receptor;Affect;Affinity;aging population;Alzheimer's Disease;antagonist;Anxiety Disorders;Area;Arrhythmia;Autoradiography;Autoreceptors;Behavior;Binding;Biological;Biological Assay;Biological Monitoring;Blood Pressure;Brain;Brain Diseases;Brain region;Carbon;Cardiac;Cardiovascular Diseases;cardiovascular emergency;Cardiovascular system;Central Nervous System;Central Nervous System Diseases;Circulation;Clinical Trials;Cognition;Collaborations;commercialization;Computer Assisted;Consumption;Contrast Media;Corpus striatum structure;Dangerousness;Data;design;Development;Diagnosis;Digestion;Disease;Docking;Dopamine;Drug Industry;Drug Kinetics;Drug Targeting;Emotions;experience;Failure;Fluorine;Funding;Future;Goals;Heart failure;Hippocampus;Hyperactivity;Hypertension;imaging agent;Imaging Device;imaging study;Immunohistochemistry;improved;in vitro Assay;instrument;interest;Intervention;invention;Investigation;Judgment;Label;Lead;Legal patent;locus ceruleus structure;Marketing;Mediating;Medical;Medical Imaging;Memory;Mental Depression;middle age;Modeling;Molecular;molecular imaging;Monitor;nanomolar;neuron loss;Neurons;Neurotransmitters;noradrenaline transporter;noradrenergic;Norepinephrine;novel;Older Population;Panic Disorder;Parents;Pathologic;Patients;Penetration;Peripheral;Pharmaceutical Preparations;Pharmacologic Substance;Physiological;Piperazines;piperidine;Positron-Emission Tomography;pre-clinical;preclinical evaluation;preclinical imaging;Prefrontal Cortex;presynaptic;prevent;Property;Proteins;Radioactive;radioligand;radiotracer;receptor;receptor binding;Research;Respiration;Risk Reduction;screening;Selection Criteria;Serotonin;side effect;Specificity;Stimulant;Study models;Substance Use Disorder;success;Synapses;synaptic function;System;Therapeutic;Time;United States;Visualization;Work;X-Ray Computed Tomography;Yohimbine

PROJECT_TITLE: Development of 1,4-Benzodioxane Derivatives as F-18 PET Radiotracers for Alpha-2C Adrenergic Receptors and Their Preclinical Evaluations

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: DURHAM

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: NARRATIVE: Radiation therapy (RT) is commonly used to treat brain tumors, however improvements are needed to make RT more effective against tumor cells and/or less damaging to normal brain cells. Our team of physicists, biologists and radiation oncologists has developed a platform to test genes and drugs as well as new types of radiation (ultra-high dose rate radiation, or FLASH-RT) to improve radiation therapy for brain tumors. This proposal describes how we will use this platform and our existing data to test combinations of standard and FLASH-RT with drugs targeting the ATM gene and other genes to improve treatment for brain tumors.

PI_NAMEs: FLOYD, SCOTT R (contact);OLDHAM, MARK ;WU, YING

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: Address;Affect;Animal Experiments;ataxia telangiectasia mutated protein;ATM gene;beamline;Behavioral;Biochemical;Biological Assay;Brain;brain cell;Brain Neoplasms;brain tissue;cancer cell;Cell Death;cell killing;Cells;Central Nervous System Neoplasms;Cessation of life;Chemicals;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Combination Drug Therapy;Combined Modality Therapy;conventional dosing;Coupling;Custom;cytotoxic;Data;Dependence;DNA Damage;Dose;Dose Rate;Drug Combinations;Drug Screening;Drug Targeting;Dryness;effective therapy;electron energy;Electrons;Experimental Neoplasms;experimental study;Functional disorder;Gamma Rays;Genes;genetic approach;Genetic Screening;genetic testing;Glioblastoma;Goals;high energy physics;Histology;Human;improved;in vivo;in vivo Model;Investigation;Knock-out;Laboratories;Libraries;Medical;Modeling;Molecular;Monitor;multidisciplinary;Mus;neoplastic cell;Neurocognitive;Neurocognitive Deficit;Neurons;neuroprotection;Normal Cell;Normal tissue morphology;novel;Nuclear;Outcome;Pathway interactions;Pharmaceutical Preparations;Physics;Probability;Protein-Serine-Threonine Kinases;Publishing;Radiation;Radiation Dose Unit;radiation effect;Radiation induced damage;Radiation necrosis;Radiation Oncologist;radiation resistance;radiation response;radiation risk;Radiation therapy;Radiation Tolerance;Radiobiology;Radiosensitization;rapid growth;repaired;Reporting;Resources;response;Role;screening;Serine;side effect;Slice;Source;success;System;Testing;Therapeutic;Toxic effect;treatment optimization;tumor;Tumor Tissue;Universities;Validation;Work

PROJECT_TITLE: Exploring synthetic lethality with a novel very high energy electron FLASH radiation beam

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Aging;Clinical Research;Digestive Diseases;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: SAINT LOUIS

ORG_DEPT: PATHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE Significant shifts in the gut microbiome are observed when humans are exposed to antibiotics or during gut inflammatory conditions, yet the causes and functional consequences of these shift events on human health, including the contributions of the gut virome, are poorly understood. The proposed study addresses this knowledge gap by leveraging an extensive collection of stools and associated clinical data from healthy or perturbed infants and adults to i) characterize the viruses associated with microbiome shift events and their bacterial hosts, ii) determine the in vitro and in vivo effects of antibiotics and inflammation on viral activities, and iii) define the immunological causes and effects of altered viromes on the mammalian host. By directly investigating viral-bacterial and viral-eukaryotic relationships, this project supports the goal of functionally characterizing the human virome to understand its role in human health and disease.

PI_NAMEs: BALDRIDGE, MEGAN T;DANTAS, GAUTAM  (contact)

PROGRAM_OFFICER_NAME: KIM, HYE-SOOK

PROJECT_TERMS: Address;Adult;Affect;Antibiotics;antimicrobial;Bacteria;bacterial community;Bacteriophages;Bioinformatics;Cell Communication;Cell Culture Techniques;Cells;Child Development;Childhood;Clinical;Clinical Data;clinically relevant;Coculture Techniques;cohort;Collection;Communities;comparative genomics;design;Diagnostic;Disease;Disease Outcome;Disease susceptibility;Ecology;Ecosystem;Environment;Equilibrium;Etiology;Eukaryotic Cell;Event;Exclusion;experience;exposed human population;Exposure to;Feces;gastrointestinal;Genomics;Gnotobiotic;Goals;gut health;gut microbiome;gut microbiota;Health;Horizontal Gene Transfer;Human;human disease;human virome;humanized mouse;Immune;Immune response;Immunologics;immunoreaction;improved;In Vitro;in vitro testing;in vivo;Infant;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;innovation;Intestines;Investigation;Knowledge;Life;life span;Link;Mammalian Cell;member;Metadata;Microbe;microbial;microbiome;microbiome alteration;microbiota;Modeling;Motivation;mouse model;Mus;Necrotizing Enterocolitis;novel;nutrient metabolism;Outcome;pathobiont;pathogen;Patients;Physiological Processes;Physiology;Play;Population;Predatory Behavior;Premature Infant;Prophage Inductions;resilience;Resolution;Role;Sampling;Shapes;stool sample;Stress;Symptoms;System;Technology;Testing;Therapeutic;Viral;Viral Genome;Viral Physiology;virome;Virus

PROJECT_TITLE: Functional characterization of viral-bacterial-human interactions during antimicrobial and inflammatory perturbations across different lifespans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-E (50)]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: PULLMAN

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Project narrative The proposed research is relevant to public health because it will determine if intraindividual cognitive variability can be used to identify early symptoms of neurodegeneration and vascular injury in American Indians, an underserved population with elevated risk of dementia due to high rates of cardiovascular disease, diabetes, and social vulnerability. The proposed work will identify less invasive ways to detect early signs of neurodegeneration, enabling earlier interventions to reduce the impact of dementia on individuals, their families, and their communities. The project is relevant to National Institute of Aging‘s mission because it will contribute new knowledge to differential diagnosis of symptomatic cognitive impairment and to develop biomarkers in asymptomatic individuals, expand and disseminate research on co-occurring conditions and dementia; and understand health differences and inequities associated with ethnic minority older adults.

PI_NAMEs: FONSECA, LUCIANA  (contact)

PROGRAM_OFFICER_NAME: GHALEH, MARYAM X

PROJECT_TERMS: Acceleration;adjudication;Adult;Affect;Age;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American Indians;Atrophic;Biological Markers;biomarker identification;Brain;Brain region;Cardiovascular Diseases;cerebral atrophy;Cerebral small vessel disease;Cerebrospinal Fluid;Cerebrovascular Disorders;Cerebrovascular Trauma;Chronic Brain Damage;Cognition;Cognitive;cognitive performance;Communities;cost;Data;Data Analyses;Data Set;Dedications;Dementia;dementia burden;dementia risk;design;Diabetes Mellitus;Differential Diagnosis;Early Diagnosis;Early identification;Early Intervention;entorhinal cortex;ethnic minority;executive function;Family;follow-up;Frequencies;Future;General Population;health difference;health disparity;health inequalities;Heart;High Prevalence;high risk;Hippocampus;imaging study;Impaired cognition;Individual;Knowledge;late life;Link;Magnetic Resonance Imaging;Measures;Memory;middle age;mild cognitive impairment;Minority Groups;Mission;mixed dementia;National Institute on Aging;Nerve Degeneration;neuroimaging;Neuronal Injury;neuropathology;Neuropsychological Tests;Neuropsychology;Non-Insulin-Dependent Diabetes Mellitus;novel;older adult;Pathologic;Performance;performance tests;Persons;Population;Populations at Risk;pre-clinical;Process;processing speed;prospective;Public Health;Research;Risk;risk mitigation;secondary analysis;social vulnerability;socioeconomic disparity;Structure;Symptoms;Testing;Time;Time Study;Underrepresented Populations;Underserved Population;unhealthy lifestyle;Validation;Vascular Diseases;vascular injury;white matter;Work

PROJECT_TITLE: Alzheimer's Disease (AD) and Vascular Brain Injury- related changes in longitudinal Magnetic Resonance Imaging associated with Intraindividual Cognitive Variability in Aging American Indians.

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Diabetes;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Nutrition;Prevention

ORG_CITY: GALVESTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: Project Narrative Motivational interviewing is an effective counseling style to affect behavior change in patients, and it has shown its promise in behaviors influencing the severity of type 2 diabetes mellitus (T2MD). However, training, consistency, and availability of a provider to preform motivational interviewing prevent it from being implemented effectively. With advances in AI and speech technology, this project examines the development and feasibility of translating some of the motivational interviewing expertise to a software agent that can help patients realize their ambivalence of their unhealthy behaviors that lead to T2DM.

PI_NAMEs: AMITH, MUHAMMAD FAHEEM (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Adherence;Affect;Amputation;Artificial Intelligence;Automation;Behavior;behavior change;behavior influence;Body fat;Centers for Disease Control and Prevention (U.S.);chatbot;Client;clinical care;clinical practice;Code;Competence;Computer Models;Computer software;computerized;computerized tools;Computers;Consumption;cost efficient;Counseling;Coupled;Data;Development;Devices;Diabetes Mellitus;diabetic;diabetic patient;Effectiveness;Empathy;Environment;evidence base;experience;Food;Goals;Habits;Health;Health behavior;Health behavior change;Human;improved;Incidence;Individual;Intelligence;Kidney Failure;Knowledge;knowledge base;Language;Lead;life span;Life Style;Light;Measures;Methodology;Methods;Modeling;motivational enhancement therapy;Names;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Ontology;Outcome;Output;Participant;Patients;Pattern;Performance;Persons;Pharmaceutical Preparations;Physical activity;pilot test;Population;Prediabetes syndrome;Prevalence;prevent;Preventive;Professional counselor;prospective;Protocols documentation;Provider;recruit;Regulation;Research;Research Personnel;Risk;Sampling;Semantics;Series;Severities;simulation;Speech;sugar;Surveys;sweetened beverage;System;Techniques;Technology;Testing;theories;Time;tool;Training;Translating;United States;usability;Work

PROJECT_TITLE: Transforming motivational interviewing into a computable model for automated patient diabetic counseling.


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Eye Disease and Disorders of Vision;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: SANTA CRUZ

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: The proposed research is relevant to public health because integrating information from different sensory modalities is a fundamental but essential brain function, and, sensory integration deficits are prominent symptoms in people with autism, schizophrenia, and ADHD. The goal of this research plan is to identify the mechanisms used during development to create the circuitry responsible for sensory integration in the mouse superior colliculus, a midbrain sensory integrative structure, and determine the consequences to behavior when integration is disrupted. These findings will provide fundamental knowledge that will enable researchers to better understand and treat disorders of sensory integration.

PI_NAMEs: FELDHEIM, DAVID A (contact);HOY, JENNIFER LYN

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Acoustic Stimulation;Adult;Affect;Age;Animals;Attention deficit hyperactivity disorder;Auditory;auditory deprivation;auditory stimulus;autism spectrum disorder;awake;Barn Owls;Behavior;Behavioral;Brain;Complex;critical period;Cues;Data;density;Detection;Development;developmental disease;Electrophysiology (science);Environment;Ephrins;experience;experimental study;Eye;Felis catus;Goals;Goggles;Growth;Gryllidae;Head;Hearing;Individual;individuals with autism spectrum disorder;Insecta;insight;interest;Investigation;Knowledge;Link;Location;Maps;Measures;Midbrain structure;Modality;Modeling;Molecular;mouse model;multimodality;multisensory;Mus;Neurodevelopmental Disorder;Neurons;novel;Pathway interactions;Phase;Photic Stimulation;Play;Population;Primates;Process;Property;Public Health;receptive field;Research;Research Personnel;response;Role;Schizophrenia;Sensory;Sensory Disorders;sensory input;sensory integration;Signal Transduction;somatosensory;Space Perception;spatial integration;Stimulus;Strigiformes;Structure;success;superior colliculus Corpora quadrigemina;Symptoms;Testing;Time;Vision;Visual;visual deprivation;visual information;visual map;visual receptive field;visual stimulus

PROJECT_TITLE: Developmental mechanisms underlying visual and auditory topographic map alignment and accurate spatial orienting behavior

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: RENO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: PROJECT NARRATIVE Preterm labor leads to preterm delivery of an underdeveloped fetus in 50% of cases. There are no FDA- approved medications available to prevent preterm delivery. The research planned in this application will employ tissues from pregnant women and mice to explore the therapeutic potential of novel ‘designed multi-ligands’ and combination tocolytics to delay preterm birth. Our research Aims are designed to address myopathic dysregulation of the uterus to advance a ‘designed multi-ligand’ and combination drug strategy to prevent preterm birth.

PI_NAMEs: BARNETT, SCOTT DANIELSON (contact)

PROGRAM_OFFICER_NAME: PAWLYK, AARON C

PROJECT_TERMS: 2019-nCoV;Address;Affinity;African American Women;Agonist;Bathing;Birth;Blood Vessels;Body Weight decreased;Caucasians;Cerebral Palsy;Cessation of life;Chemicals;Clinical;Combined Modality Therapy;Connexin 43;COVID-19 impact;delayed birth;design;Diffusion;disability;Disease;Dose;Drug Combinations;Drug Kinetics;Drug usage;Enteral;Exhibits;experience;Exposure to;extreme prematurity;Failure;FDA approved;fetal;Fetal Reduction;Fetus;gap junction channel;Gap Junctions;Generations;Goals;Health;Heart;Hour;Human;improved;in vivo;Infection;innovation;Label;Laboratories;Learning Disabilities;Life;Ligands;Ligation;Measurement;Measures;Medical;Metabolism;Mifepristone;Molecular Weight;Mothers;mouse model;Mus;Myometrial;myometrium;Nature;Nitric Oxide;Nitrosation;novel;novel therapeutics;Organ;Outcome;Oxidoreductase;Oxytocin;Pathway interactions;Penetration;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacology;Placenta;placental transfer;Pregnancy;Pregnant Women;premature;Premature Birth;Premature Infant;Premature Labor;prenatal exposure;prevent;Production;Progesterone;Property;Protein S;Relaxation;Research;respiratory;Risk;S-Nitrosoglutathione;Signal Transduction;small molecule;small molecule therapeutics;Smooth Muscle;success;Targeted Research;Techniques;Testing;Therapeutic;Time;Tissues;Tocolysis;Tocolytic Agents;uptake;Uterus;women's treatment

PROJECT_TITLE: Novel Designed Multi-Ligands as Tocolytics for Dysregulated Myometrial Pathways in the Treatment of Preterm Labor

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;Human Genome;Immunization;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Precision Medicine;Prevention;Vaccine Related

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Relevance to Public Health: The ongoing COVID-19 pandemic has infected hundreds of millions, estimated to have resulted in over 15 million deaths, and has caused incalculable economic damage and social disruption worldwide. This grant will identify and develop comprehensive information on the contribution and influence of genetic variants and phenotypic characteristics/comorbidities on COVID-19 infection- and/or vaccine-induced immune responses. These data will help us understand how and why people do and do not respond appropriately to these vaccines, help us to give the right vaccine to the right person at the right time, and may help predict re-infection risk.

PI_NAMEs: KENNEDY, RICHARD B (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 2019-nCoV;Acute Respiratory Distress Syndrome;Affect;Age;Alleles;Antibody Formation;Antibody Response;Antibody titer measurement;Attention;B-Lymphocytes;biobank;Biological Markers;blood group;Blood typing procedure;Body mass index;Cells;Cessation of life;Characteristics;Clinic;Clinical;clinical phenotype;Clinical Trials;Code;cohort;Cohort Studies;comorbidity;cost;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 severity;COVID-19 vaccination;COVID-19 vaccine;cytokine;Data;design;Development;Diabetes Mellitus;Disease susceptibility;Dose;Economics;Effectiveness;Ethnic Origin;experience;Funding;Genes;Genetic;genetic architecture;genetic association;Genetic Polymorphism;genetic variant;Genetic Variation;genome wide association study;genome-wide;genomic locus;Grant;Haplotypes;Hybrids;IL17 gene;Immune;Immune Evasion;Immune response;Immunity;Immunogenetics;Immunologic Markers;Individual;Infection;infection risk;Influenza;influenza virus vaccine;insight;Integration Host Factors;inter-individual variation;Interferon Type II;Interferons;Interleukin-2;interleukin-21;Interleukin-4;International Classification of Disease Codes;Laboratories;Long-Term Effects;Measles;Measles Vaccine;Measures;Mississippi;Modeling;Mumps;neutralizing antibody;novel;Obesity;Participant;Pathway interactions;Persons;phenome;Phenotype;polygenic risk score;Population;Population Study;Post-Acute Sequelae of SARS-CoV-2 Infection;programs;protective efficacy;Public Health;Race;Recording of previous events;Reproducibility of Results;Research;Research Personnel;response;Risk Factors;Rubella;Rubella virus vaccine;SARS-CoV-2 immune response;SARS-CoV-2 immunity;SARS-CoV-2 infection;SARS-CoV-2 spike protein;secondary analysis;Severities;Severity of illness;sex;Shapes;Smallpox Vaccine;social;T-Lymphocyte;Testing;Time;treatment response;Universities;unvaccinated;Vaccinated;Vaccination;vaccine efficacy;vaccine immunogenicity;Vaccine Research;vaccine safety;vaccine-induced immunity;Vaccinee;Vaccines;Vaccinia;Variant;Viral;Viral Vaccines;Work

PROJECT_TITLE: Immunogenetics of COVID-19 Immune Response

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


NIH_SPENDING_CATS: Aging;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE The human brain has approximately equal numbers of glia cells and neurons, and interactions between these cells are essential for all nervous system functions. Impaired glia-neuron interactions underlie many neurological diseases including Alzheimer's disease, Autism, epilepsy and may contribute to age-related neural decline. To understand glial contribution to nervous system health, aging and disease, we will dissect glia-neuron interactions with exquisite speed and molecular resolution in vivo by using a powerful genetic model we recently established.

PI_NAMEs: SINGHVI, AAKANKSHA  (contact)

PROJECT_TERMS: Address;Age;age related;age related decline;Aging;Alzheimer's Disease;Animal Behavior;Animals;autism spectrum disorder;Binding;Brain;Caenorhabditis elegans;Cell Shape;cell type;Cells;Cellular biology;connectome;Dendritic Spines;Disease;disease model;Dissection;Environment;Epilepsy;Functional Imaging;Genetic;Genetic Models;Genomics;Grant;Health system;Human;Impairment;in vivo;Interneurons;Learning;life span;Maps;Memory;Molecular;mutant;Nervous System;Nervous System Disorder;Nervous System Physiology;neural;Neuroglia;Neurons;Neurophysiology - biologic function;novel;Parkinson Disease;Pathway interactions;Perception;Protein Biochemistry;Reproducibility;Resolution;Role;Sensory;Shapes;Site;Speed;Study models;Techniques

PROJECT_TITLE: Molecular dissection of glia-neuron interactions


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research

ORG_NAME: WILLS EYE HEALTH SYSTEM

PHR: Narrative Statistical analysis of big data from electronic medical records or other sources such as the national American Academy of Ophthalmology IRIS® registry can provide high impact evidence regarding disease diagnosis, surveil- lance and treatment, including studying rare events. However, these study designs are subject to selection bias and unreliable results due to subgroups with sparse data caused by imbalances among patient categories, and analysis of millions of records on patient level is a significant computational investment of time and cost, during which software and/or computer crashes often occur. We aim to develop novel subsampling strategies such that sufficient data will be selected to guarantee statistical efficiency and unbiased estimation of covariate effects for both rare and non-rare events and we will build new statistical software for the eye and medical community to use when they analyze big data from EMRs including the IRIS registry.

PI_NAMEs: WANG, HAIYING ;ZHANG, QIANG  (contact)

PROGRAM_OFFICER_NAME: EVERETT, DONALD F

PROJECT_TERMS: Academy;Address;Affect;Age;Algorithms;American;Area;Asian Americans;Attention;Big Data;Categories;Clinical Data;cloud platform;cohort;Communities;Computer software;Computerized Medical Record;Computers;Computing Methodologies;Confidence Intervals;Connecticut;Control Groups;cost;Data;Data Analyses;data registry;Data Set;data sharing;Databases;design;Development;Disease;disease diagnosis;Disease Outcome;Disparity;Elderly;Electronic Health Record;Environment;Event;Eye;Eye diseases;Face;Female;Genetic Recombination;Grant;health disparity;Health protection;Hospitals;improved;Incidence;Individual;innovation;Investments;Measurement;Medical;Medical Research;medical specialties;Methodology;Methods;Midwestern United States;Minority;Minority Groups;Modeling;novel;novel strategies;Numeric Rating Scale;Observational Study;Ophthalmology;Outcome;Output;Patients;Performance;Population;Prevalence;prevent;primary outcome;Probability;Process;Property;Rare Diseases;Records;Registries;Research;Research Design;Research Personnel;Risk Factors;Running;Sample Size;Sampling;Secure;Selection Bias;Site;Source;Statistical Data Interpretation;Subcategory;Subgroup;Testing;Time;tool;trustworthiness;Underrepresented Minority;Underrepresented Populations;United States;Universities;user friendly software;Vision

PROJECT_TITLE: Novel subsampling and analysis of big data using examples from IRIS ® Registry

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (02)]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: DAVIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE [parent project] Extracellular vesicles (EVs) show great promise as next-generation targeted drug delivery systems, but their complexity and heterogeneity in structure, composition, and function have stalled their translational use. In this study we propose physicochemical approaches to homogenize EVs and fuse them with synthetic drug loaded liposomes to engineer a drug delivery vehicle that delivers a therapeutic payload with high intracranial uptake. We will test the safety and biodistribution of the engineered product as well as its efficacy in a glioblastoma orthotopic mouse model

PI_NAMEs: CARNEY, RANDY  (contact);WANG, AIJUN

PROGRAM_OFFICER_NAME: DARINGER, NICHOLE MARIE

PROJECT_TERMS: Address;Astrocytes;Behavior;Biochemical;Biodistribution;Biological;Biological Assay;Biological Availability;Biological Process;biomaterial compatibility;Bioreactors;Blood - brain barrier anatomy;blood-brain barrier crossing;Brain;Breast Cancer Cell;Cancer cell line;Cell Line;cell type;Cells;Chemicals;Clinical;clinical practice;combat;Complex;controlled release;delivery vehicle;design;Disease;Disseminated Malignant Neoplasm;Dose;Drug Delivery Systems;drug release profile;Drug Targeting;efficacy study;Endothelium;Engineering;Exhibits;expectation;extracellular vesicles;Failure;FDA approved;Feedback;Formulation;Foundations;functional improvement;Glioblastoma;Goals;Good Manufacturing Process;Half-Life;Heterogeneity;Hybrids;Image;Immune;immune clearance;in vivo;innovation;interest;Label;Libraries;Ligands;Liposomes;loss of function;Malignant neoplasm of brain;Malignant Neoplasms;Measures;Mechanics;Mediating;Medicine;Methods;Microfluidics;mimetics;Modeling;Molecular;mouse model;Mus;nanoarchitecture;nanocarrier;nanomaterials;nanoparticle;nanoscale;Nervous System Disorder;neural;Neurodegenerative Disorders;Neuroglia;Neurons;next generation;novel;novel strategies;parent project;particle;Pathway interactions;Patients;Penetration;Performance;personalized care;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phase I Clinical Trials;Population;Property;Proteins;receptor;Reporting;Research;RNA;Safety;safety study;safety testing;Shapes;Solid;Source;Sterility;Structure;success;synthetic drug;System;Techniques;temozolomide;Testing;Therapeutic;Tissues;tool;Toxic effect;transcytosis;Translating;Treatment Efficacy;Tropism;tumor;uptake;Vision;Work

PROJECT_TITLE: Homogenized, engineered extracellular vesicles for intracranial targeting

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Sleep Research;Substance Misuse

ORG_CITY: MERCED

ORG_NAME: UNIVERSITY OF CALIFORNIA, MERCED

PHR: PROJECT NARRATIVE Binge drinking both induces ethanol tolerance and has complex and lasting effects on sleep. We and others discovered clues that sleep genes and brain circuits encode aspects of ethanol tolerance. Our goal is to determine the extent of the genetic and circuit overlap; our results will lead to in-depth understanding of the tolerance:sleep relationship and potentially point to ways to manage alcohol's effects on sleep.

PI_NAMEs: WOLF, FREDERICK W (contact)

PROGRAM_OFFICER_NAME: KUMAR, SHAILESH

PROJECT_TERMS: Acute;addiction;Adult;Affect;alcohol effect;alcohol exposure;alcohol response;alcohol reward;alcohol risk;alcohol use disorder;Alcohols;Anatomy;base;Behavior;Behavioral;binge drinking;Brain;Brain region;Characteristics;Chronic;circadian;circadian pacemaker;Circadian Rhythms;Complex;cost;Data;density;Development;Disease;Dose;Drosophila genus;Elements;Ethanol;experimental study;fly;Funding;Future;gene conservation;Gene Expression Regulation;Generations;Genes;Genetic;genetic manipulation;Glutamates;Goals;Human;Individual;knock-down;Learning;Link;Literature;Mammals;Maps;Measures;Memory;memory consolidation;Metabotropic Glutamate Receptors;Methods;Molecular;Mood Disorders;Mutation;Nervous System Disorder;neural;neural circuit;neuroadaptation;Neurodegenerative Disorders;Neurons;Organism;Outcome;Pacemakers;pharmacologic;Physiological;Physiology;Play;preference;presynaptic;Property;rapid test;Research;Rodent;Role;Sleep;Sleep disturbances;sleep regulation;Surveys;Synaptic plasticity;synergism;Testing;Time;tool;Transgenic Organisms;translational potential;Work

PROJECT_TITLE: Alcohol tolerance encoding in sleep and memory circuits

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Genetics

PHR: PROJECT NARRATIVE Transcription coupled-nucleotide excision repair (TC-NER) plays a critical role in maintaining genome stability by repairing DNA lesions that would otherwise disrupt the expression of genes; however, a number of the key steps in TC-NER remain poorly defined. This proposal aims to characterize the molecular basis by which the transcription elongation factor Elf1 regulates TC-NER through its carboxyl-terminal domain (CTD), and how the Elf1 CTD is regulated by phosphorylation and the elongation factors Spt4/Spt5. Successful completion of these aims should provide new insights into the functions of a key proteins that regulate transcription-coupled DNA repair.

PI_NAMEs: SELVAM, KATHIRESAN ;WYRICK, JOHN J (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Aging;Antibodies;Binding;Biochemistry;C-terminal;casein kinase II;Cells;Cockayne Syndrome;Complex;Coupled;Data;Defect;Development;DNA Damage;DNA lesion;DNA mapping;DNA Repair;Drosophila genus;Elongation Factor;Exhibits;Gene Expression;gene repair;gene repression;Genetic Transcription;Genome Stability;genome-wide;genome-wide analysis;Health;Homologous Gene;Human;In Vitro;Inherited;insight;Lesion;Maintenance;Mammalian Cell;Methods;Molecular;Mutate;Mutation;Nerve Degeneration;Orthologous Gene;Pathway interactions;Patients;PH Domain;Phosphorylation;Phosphorylation Site;Play;Polymerase;prevent;Proteins;Pyrimidine Dimers;recruit;repaired;response;RNA Polymerase II;Role;Saccharomyces cerevisiae;Saccharomycetales;scaffold;Sequence Analysis;Symptoms;Syndrome;Testing;Transcription Elongation;transcription factor TFIIH;Transcription-Coupled Repair;Transcriptional Elongation Factors;Ubiquitination;ultraviolet;ultraviolet damage;Ultraviolet Rays;UV induced;yeast genetics;yeast genome;Yeasts

PROJECT_TITLE: The role of Elf1 in transcription coupled-nucleotide excision repair

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-M (02)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Digestive Diseases;Lewy Body Dementia;Microbiome;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention;Sleep Research

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE The physical, emotional, and societal costs of Lewy body diseases (LBD), including Parkinson’s disease and dementia with Lewy bodies, will increase over the coming decades as more of us live longer; in fact, the number of people with LBD is expected to double in the USA by the year 2040 unless we find safe and effective means to cure, delay onset, or slow progression of these diseases. Non-motor features, including gastrointestinal symptoms like constipation, are a common feature of LBD with serious subsequent impact on quality of life and caregiver burden. By determining the interplay between the gut microbiota and immune system, our project is focused on the clear imperative to understand the role of gut health in the pathogenesis of LBD.

PI_NAMEs: BECKER, LAREN ;POSTON, KATHLEEN LOMBARD (contact)

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: Accelerometer;Activities of Daily Living;Affect;Aging;alpha synuclein;Animal Model;Antibodies;Ascending colon;B-Lymphocytes;Bile Acids;Biological;Biological Assay;Biopsy;Biopsy Specimen;Blood;Bradykinesia;Brain;Brain Pathology;C57BL/6 Mouse;Caregiver Burden;CD14 gene;CD19 gene;CD8B1 gene;Cell Separation;Cells;Characteristics;chemokine;Clinical assessments;Colon;Colonoscopy;Constipation;cytokine;Data;Dementia;Dementia with Lewy Bodies;Dendritic Cells;Detection;Devices;Disease;Disease Progression;Ear;Electrocardiogram;Electroencephalography;Emotional;Enteral;Enteric Nervous System;Environment;experimental study;fecal transplantation;Feces;Flow Cytometry;Frequencies;Functional disorder;gastrointestinal;gastrointestinal symptom;Gastrointestinal tract structure;Gene Expression Profiling;Genetic;genetic signature;gut health;gut microbiome;gut microbiota;Immune;immune function;Immune response;Immune system;Immunoassay;Immunologics;immunoregulation;In Vitro;Individual;Inflammatory;Injections;innovation;Intervention;ITGAM gene;ITGAX gene;Lewy Body Disease;Lewy body pathology;Link;Macrophage;Mediating;Mediator;metabolomics;Metagenomics;microbial;microbiota;microbiota composition;Microglia;Modeling;Molecular;Motility;Motor;motor symptom;multidisciplinary;multimodality;Mus;Myelogenous;nano-string;Natural Immunity;Nervous System Disorder;Neurodegenerative Disorders;Neuroimmune;Neurologic;new technology;novel;novel strategies;Organ;Parkinson Disease;Pathogenesis;Pathologic;Pathway interactions;Patients;Peripheral;Peripheral Nervous System;Persons;Phenotype;Physiological;Physiology;Play;Polyethylene Glycols;Population;prevent;Prevention;Prevention strategy;PTPRC gene;Quality of life;recruit;REM Sleep Behavior Disorder;Research;Resolution;Risk;risk stratification;Role;screening;Serum;Shotguns;Sleep;societal costs;Sorting;Stomach;stool sample;Structure;Surveys;Symptoms;T-Lymphocyte;Technology;Testing;Therapeutic Intervention;Tissues;Toxin;Tremor;uptake;Volatile Fatty Acids;wearable device

PROJECT_TITLE: Role of altered gut immune response in Lewy Body Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-C (M2)]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_CITY: SANTA BARBARA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: PROJECT NARRATIVE Transgender youth face a high risk for serious mental health problems (e.g., suicidality, depression, anxiety) relative to cisgender youth due to their disproportionate exposure to transphobic discrimination and trauma, and significant barriers to mental health care. The proposed project seeks to increase mental health care access for transgender youth by enhancing the dissemination of evidence-based mHealth interventions through the design of a gender-affirming training intervention for lay health workers (LHWs), with cultural tailoring for transgender youth of Color and their caregivers. The aims of the current project are to: (Aim 1) co- design a mechanism-driven gender-affirming training intervention for LHWs, then (Aim 2) build the gender- affirming LHW training intervention via usability testing.

PI_NAMEs: BARNETT, MIYA  (contact);PRICE, MAGGI

PROGRAM_OFFICER_NAME: LUSHIN, VICTOR

PROJECT_TERMS: Address;Adherence;Anxiety;Attitude;Behavior;black patient;care systems;Caregiver support;Caregivers;Caring;Child Mental Health;children of color;cisgender;Color;Communities;community partners;Competence;Complex;cultural health;Data;design;Discrimination;disparity reduction;Educational Intervention;Effectiveness;Enrollment;Evaluation;evidence base;experience;Exposure to;Face;Family;Feedback;Focus Groups;gender affirmation;Goals;Health;health care availability;health equity promotion;health inequalities;Health Personnel;Health Services;Health Services Accessibility;high risk;human centered design;improved;Individual;innovation;interest;Intervention;intervention refinement;Interview;Investigational Therapies;Knowledge;Language;Latinx;Lived experience;Mental Depression;Mental disorders;Mental Health;Mental health promotion;Mental Health Services;method development;Methods;mHealth;mhealth interventions;minority stress;Modeling;National Institute of Mental Health;online intervention;Outcome;Parents;Patients;Population;Price;prototype;Provider;psychoeducation;Public Health;racial discrimination;racial diversity;Research;Research Support;response;Risk;satisfaction;Self Efficacy;Services;Site;skills;Specific qualifier value;suicidal;Technology;Terminology;Testing;therapy development;Thinking;Training;transgender;transphobia;Trauma;usability;verbal;Work;Youth

PROJECT_TITLE: Design of a Lay Health Worker Training Intervention to Promote Mental Health Care Access for Racially Diverse Transgender Youth

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Drug Abuse (NIDA only);Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pain Research;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: Los Angeles

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative This Diversity Supplement will support Ms. Blevins to examine the role of psychological pain in the relationship between discrimination and substance use among Black, Indigenous, and Persons of Color (BIPOC) adults, who have been and continue to be impacted by discrimination and other social stressors on a daily basis, including when seeking healthcare. We will conduct focus groups and use daily questionnaires via a smartphone application to study the specific factors that influence substance use among BIPOC adults, which will inform and support data collection pertaining to healthcare discrimination and psychological pain in patients who use substances and are seeking care within the Emergency Room at Los Angeles General Medical Center. Together with the parent study, this will be the first study to provide an in-depth description of the impact of discrimination on substance use behaviors and addiction vulnerability in the context of daily and prolonged psychological pain among BIPOC adults.

PI_NAMEs: HUH, JIMI  (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: Accident and Emergency department;Acute;addiction;Address;Adult;adult of color;Alcohols;Attention;Behavior;Benzodiazepines;Biological;biopsychosocial;Black, Indigenous, People of Color;Cannabis;care seeking;Characteristics;Chronic;Clinical;Cocaine;Collaborations;Collection;Color;Communities;Complex;coping;Data;Data Collection;Data Set;Diagnosis;Discrimination;distraction;Distress;Emergency Care;Emergency department visit;emotional distress;ethnic minority;Exhibits;experience;Feeling;Focus Groups;Fright;Future;Gender;General Population;Guidelines;Guilt;Health;Health behavior;health equity;Health Personnel;Healthcare;humiliation;improved;Individual;Inequity;Intervention;Investigation;Knowledge;Label;Life;Link;Los Angeles;marginalization;marginalized population;Measures;Mediating;Mediator;Medical center;Mental Health Services;Methamphetamine;Methodology;Nicotine;Opioid;Outcome;Pain;pain behavior;parent project;Parents;Participant;patient population;Patients;Pattern;people of color;perceived discrimination;Personal Satisfaction;Persons;Pharmaceutical Preparations;Play;Policies;polysubstance use;Process;psychologic;Questionnaires;racial discrimination;Reporting;Research;Research Personnel;Resources;response;Risk;Role;Sampling;Scientist;Shame;smartphone application;social;social influence;social stigma;social stress;social stressor;sociodemographic factors;Stigmatization;Stress and Coping;stressor;substance use;Substance Use Disorder;Surveys;Testing;Thinking;tool

PROJECT_TITLE: The influence of social stress on polysubstance use and addiction vulnerability among adults in communities of color: The mediating role of psychological pain

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Precision Medicine;Radiation Oncology

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Narrative The overall goal of this work is to improve outcomes for neuroendocrine tumor (NET) patients by fashioning cost effective, patient friendly technology to enable 177Lu-DOTATATE treatment personalization based upon daily, at- home measurements of the radioactivity in their organs at risk and tumors. We are developing compact, durable, easily transportable technology that will enable treatment personalization while forgoing the need for serial visits to imaging centers over 7 plus days for each treatment administration.

PI_NAMEs: MIYAOKA, ROBERT S (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: Abbreviations;absorption;Aftercare;Clinic;Clinical;clinical practice;Clinical Trials;cohort;Collimator;Computer software;cost effective;Data;Deposition;design;detector;Devices;Diagnosis;digital;Dose;dosimetry;Electronics;Electrons;Friends;Gamma Cameras;Gamma Rays;Goals;Home;Image;imaging detector;imaging facilities;imaging study;Imaging Techniques;improved;improved outcome;Individual;individual patient;Injections;interest;Kidney;Maximum Tolerated Dose;Measurement;Measures;Methodology;Methods;monitoring device;Neuroendocrine Tumors;Organ;Patients;personalized medicine;Persons;PET/CT scan;Physicians;portability;Positioning Attribute;precision medicine;Progression-Free Survivals;Protocols documentation;Publications;Qualifying;quantitative imaging;Radiation;Radiation Monitoring;Radiation therapy;Radioactivity;Radiolabeled;Resolution;Resources;Retreatment;Retrospective Studies;Risk;Scientist;Series;side effect;simulation;single photon emission computed tomography;Site;Software Tools;somatostatin receptor 2;standard of care;Supination;Supine Position;targeted treatment;Technology;theranostics;Therapeutic;therapeutic effectiveness;Therapeutic Equivalency;Time;tool;tumor;Tumor Biology;United States;Visit;wearable device;Work;X-Ray Computed Tomography

PROJECT_TITLE: The Personalized Remote Radiation Tracking Portable Organ Dosimetry Devise (PRRT PODD)


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biotechnology;Infectious Diseases

ORG_CITY: TORRANCE

ORG_NAME: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER

PHR: Narrative This proposal is to modernize the C.W. Steers Biological Resources Center (BRC) to meet its growing sterilizing needs by purchasing a new efficient sterilizer with a water conservation vacuum system which will support high-quality animal research in the areas of infectious and chronic disease; modernize the facility by enabling advancement in operations and improving efficiencies; and implement green technology.

PI_NAMEs: GUERRA, CATALINA MARIA (contact)

PROGRAM_OFFICER_NAME: LI, XIANG-NING

PROJECT_TERMS: Animal Experimentation;animal resource;Animals;Area;Award;Bacteria;Biological;Biological Products;Biotechnology;Chronic Disease;Communicable Diseases;Communities;Contracts;Dedications;design;Diabetes Mellitus;Disease;Ensure;Equipment;Funding;fungus;Gene Modified;Grant;Growth;High temperature of physical object;Housing;immunosuppressed;improved;innovation;Laboratory Animals;Malignant Neoplasms;manufacture;Medical center;meetings;Methods;Modernization;Mucopolysaccharidosis III;Mus;operation;pandemic disease;Population;pre-clinical research;Predisposition;pressure;prevent;Principal Investigator;programs;Ramp;Reproduction spores;Research;Research Contracts;Research Personnel;Resources;Rodent;Services;Sterility;Sterilization;System;Technology;Time;tool;Transgenic Mice;Vacuum;Virus;water conservation

PROJECT_TITLE: BRC Modernization of Sterilizing Equipment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-U (91)]


NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Clinical Research;Headaches;Migraine;Neurosciences;Pain Research

ORG_CITY: CAMBRIDGE

ORG_NAME: CAMBRIDGE HEALTH ALLIANCE

ORG_STATE: MA

PHR: PROJECT NARRATIVE Migraine is characterized by dysregulation of the autonomic nervous system, including functional and structural alterations of the insula, and by sensitization to pain and interoceptive sensations such as nausea as a function of the phase of the episodic migraine cycle. The aim of this proposal is to investigate whether neural mechanisms of interoceptive awareness are altered in individuals with episodic migraine, and to what extent interoceptive awareness varies across phases of the episodic migraine cycle. In the proposed project, we will use functional MRI to compare brain response in the insula during an interoceptive attention task between people with episodic migraine versus healthy control participants, and will examine how that response varies across phases of the migraine cycle.

PI_NAMEs: DATKO, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: OSHINSKY, MICHAEL L

PROJECT_TERMS: Affective Symptoms;Anterior;Attention;Autonomic nervous system;Award;Awareness;blood oxygen level dependent;blood oxygenation level dependent response;Brain;Brain region;chronic painful condition;Clinical;Data;design;diaries;Electronics;Esthesia;experience;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;Funding;Goals;Grant;habituation;Headache;Heart;improved;Individual;Insula of Reil;Interoception;Intervention;Investigation;Link;Lung;Measures;Migraine;mindfulness;MRI Scans;National Center for Complementary and Integrative Health;Nausea;neural;Neurobehavioral Manifestations;neuromechanism;novel;Pain;pain processing;pain sensitivity;Parasympathetic Nervous System;Parents;Participant;Patients;Pattern;Perception;Persons;Phase;Play;prevent;Program Research Project Grants;Protocols documentation;Regulation;Reporting;Research;Research Project Grants;response;Rest;Role;sample fixation;Scanning;Sensory;Severities;Signal Transduction;somatosensory;sound;Stimulus;Stress;Symptoms;System;Techniques;Time;Visual

PROJECT_TITLE: Investigating neural mechanisms of interoceptive awareness in migraine

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Infectious Diseases;Nutrition;Prevention;Social Determinants of Health

PHR: PROJECT NARRATIVE Cardiometabolic diseases like hypertension and type II diabetes are increasing globally, particularly in low- and middle-income countries, but little evidence exists for strengthening health systems and their existing care platforms to address this burden or for prevention strategies that can be deployed in community settings. This project leverages data from ongoing R01, UG3/UH3, and intramural grants to conduct formative research into implementation determinants for integrating type II diabetes care into HIV and hypertension care cascades, and to explore whether community-based nutritional education can improve diet, a well-established contributor to cardiometabolic disease risk. This research will inform efforts to strengthen cardiometabolic care by building on successes and existing assets within the health system, such those for HIV care, as well as community-based interventions for preventing cardiometabolic disease, while providing opportunities for the F31 candidate to gain expertise in new methods and advance as an independent investigator.

PI_NAMEs: BRUMWELL, AMANDA  (contact)

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: acceptability and feasibility;Achievement;Address;Administrator;Affect;Africa South of the Sahara;African;Analysis of Variance;Assessment tool;burden of illness;Cardiometabolic Disease;cardiometabolism;Caring;Cause of Death;Cessation of life;Chronic Disease;citizen science;Clinical;Code;Communicable Diseases;Communities;Community based prevention;Community Health Education;community intervention;community setting;Consolidated Framework for Implementation Research;Coupled;Data;Data Collection;Development;Diabetes Mellitus;Diet;Diet Modification;Dietary intake;disability-adjusted life years;Disease;disorder risk;Doctor of Philosophy;Dose;Eating;Education;Environment;Epidemiology;experience;Exposure to;Focus Groups;food environment;Future;global health;Grant;Health;Health behavior;Health care facility;health organization;Health system;HIV;Hypertension;implementation determinants;implementation framework;implementation research;implementation science;implementation strategy;improved;Incidence;Individual;Injury;Institution;integrated care;interest;Interview;Learning Module;low and middle-income countries;Medical;member;Methods;Modeling;Morbidity - disease rate;mortality;Mother-to-child HIV transmission;Mozambique;Non-Insulin-Dependent Diabetes Mellitus;Nutrition Assessment;Nutritional;organizational readiness;Outcome;parent grant;Parents;Patients;Pattern;Persons;Pilot Projects;Population;population based;pre-doctoral;Prevalence;prevent;Prevention;Prevention strategy;programs;Public Sector;Qualitative Research;Questionnaires;Reporting;Research;Research Methodology;Research Personnel;research study;response;Risk Factors;service delivery;Services;Statistical Data Interpretation;success;Surveys;System;Systems Analysis;Techniques;Theoretical Domains framework;Training;trend;Universities;Washington

PROJECT_TITLE: Implementation determinants and community-based prevention for cardiometabolic disease in Mozambique: a pilot study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (21)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Complementary and Integrative Health;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: GAINESVILLE

ORG_NAME: OUTLIER TECHNOLOGY, LLC

ORG_STATE: FL

PHR: Project Narrative  Recent insights into the pathogenesis of Alzheimer’s Disease (AD) suggest therapies which manipulate the plasticity of neural circuits will be central to the next-generation of treatments to slow and/or reverse its progression. Toward this end, Outlier Technology proposes the development of a novel, Neurologic Music Therapy (NMT) platform that offers evidence-based interventions to stimulate neuroplasticity, mitigate cognitive decline, and prolong functional independence in individuals suffering from AD. This proposal describes the development of a gesture-powered “smart instrument” that combines an interactive, therapeutic, personalized music creation experience with structured data analytics and a curriculum of NMT games/puzzles that adapt to the users’ sensitive needs and musical tastes; allowing them to “play” their way to better health.

PI_NAMEs: GRAY, PETER  (contact)

PROGRAM_OFFICER_NAME: PLUDE, DANA JEFFREY

PROJECT_TERMS: Acceleration;Address;aging related disease;algorithm training;Algorithms;Alzheimer's Disease;Alzheimer's disease patient;Board Certification;Brain;Brain region;brain repair;brain tissue;Catalogs;cerebral atrophy;Cerebral hemisphere;Characteristics;Childhood;Clinical Trials;Cognition;Cognitive;Collaborations;Communication;Communities;computer science;Computer software;Computer Vision Systems;Curriculum Management System;Data;Data Analytics;Data Display;data portal;deep learning;design;Development;Diagnosis;Disease;Disparate;Educational Curriculum;Elements;Emotional;Esthetics;Event;evidence base;Evidence based intervention;executive function;experience;Feasibility Studies;Feedback;Focus Groups;functional independence;Gestures;Goals;Habilitation;haptic feedback;healing;Health;Human;Impaired cognition;Impairment;Improve Access;improved;Individual;innovation;insight;instrument;Intervention;Intuition;Learning;Life;Lighting;Machine Learning;Maps;Medical;Memory;Methods;Modality;Modeling;Modernization;Motion;Motor;Movement;Music;Music Therapy;musician;neural;neural circuit;neural network;Neurodegenerative Disorders;Neurologic;Neuronal Plasticity;neuropathology;Neurosciences;next generation;novel;novel strategies;Nutrient;Outcome;pain reduction;Pathogenesis;Patient-Focused Outcomes;Patients;Pattern Recognition;Personal Satisfaction;Persons;Pharmaceutical Preparations;Phase;Play;Process;programs;prototype;regression algorithm;Rehabilitation therapy;repaired;Resources;Sampling;Senile Plaques;Social outcome;Source;Structure;structured data;success;symptom management;System;targeted treatment;Taste Perception;tau aggregation;Technology;Therapeutic;therapeutic candidate;Therapeutic Intervention;Time;Toxin;Training;trait;Translating;Treatment Protocols;usability;Validation;Variant;Well in self

PROJECT_TITLE: A Gesture-Powered Software Platform of Neurologic Music Therapy Games and Puzzles: To Stimulate Neuroplasticity and Prolong Functional Independence in Individuals Diagnosed with Alzheimer's Disease


ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE In this application for “Modern Equipment for Shared-use Biomedical Research Facilities”, the Genomics Research and Technology Hub, the shared genomics resource for the University of California, Irvine, proposes acquisition of the Hamilton LiquidScan NGS STAR robotic system, which is readily programmable for next generation sequencing workflows to enable automation of multiple steps in genomics sample processing for various genomic, transcriptomic and multiomic sequencing, and beadarray experiments. Increased automation will further support recent increases in throughput for long- and short-read sequencing platforms, and the new LiquidScan feature enables translational development of biomarker assays from biological fluids. This modernization of infrastructure will leverage our trained personnel, provide relief from physically repetitive tasks, and improve accuracy and precision within the workflow.

PI_NAMEs: SANDMEYER, SUZANNE  (contact)

PROJECT_TERMS: Address;Adoption;Automation;Bar Codes;Biological Assay;Biological Markers;biomarker development;Biomedical Research;California;Cells;Charge;Clinical;Clinical Research;Controlled Environment;Core Facility;DNA;Educational workshop;Equipment;experimental study;Exposure to;extracellular vesicles;Genomics;Genomics Shared Resource;high throughput technology;Human Resources;improved;Individual;Industry;Infrastructure;instrument;Laboratories;Libraries;Liquid substance;Manuals;Manufacturer;Maps;Medical center;medical schools;Modernization;Monitor;multiple omics;Needles;next generation sequencing;parallelization;Pathology;post-COVID-19;Preparation;Price;Process;programs;Quality Control;Reagent;Reporting;Reproducibility;Research;research facility;Research Personnel;robotic system;robotic training;Robotics;Sampling;Sampling Errors;Schools;Science;sequencing platform;Services;single-cell RNA sequencing;Stress;System;Technology;Testing;Time;Training;Training Programs;transcriptomics;University resources;virtual;Walking;Work

PROJECT_TITLE: Automation of Sample Preparation for a Genomics Shared Resource


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Machine Learning and Artificial Intelligence;Patient Safety

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative The Nav1.5 subunits of FGF12A, FGF12B, and calmodulin have been shown to individually modulate the cardiac sodium current. This proposal looks to determine the combined effects on these subunits have on Nav1.5 and class 1b anti-arrhythmic drug interactions with Nav1.5. The results from the proposed studies will clarify potential differences in the treatments of pro-arrhythmic patients and will develop methods to characterize similar auxiliary subunits on voltage gated ion channels.

PI_NAMEs: WOODBURY, LUCY SUMMER (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Action Potentials;Address;Affect;Affinity;Anti-Arrhythmia Agents;Arrhythmia;Binding;Biophysics;Calmodulin;Cardiac;Cardiac Myocytes;clinical application;Data;design;Development;Diagnosis;DNA Sequence Alteration;Drug Interactions;Effectiveness;Electrophysiology (science);FGF12 gene;Fibroblast Growth Factor;Fluorescence Resonance Energy Transfer;Fluorometry;Goals;Heart;Heart failure;Human;Image;Individual;innovation;insight;Ion Channel Gating;Kinetics;Lead;Left ventricular structure;Lidocaine;Machine Learning;machine learning algorithm;machine learning model;Methods;Mexiletine;Molecular Conformation;novel;Pathology;patient response;Patients;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Physiological;programs;Protein Isoforms;Protocols documentation;ranolazine;Regulation;Research;response;Scientist;Series;Sodium;Sodium Channel;Stretching;Techniques;Technology;Testing;Time;Training;training data;Translational Research;United States;Up-Regulation;Validation;voltage;voltage clamp;Work

PROJECT_TITLE: Investigating the interactions of auxillary subunits with the Nav1.5 channel


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Hematology;Liver Cancer;Liver Disease;Nutrition;Rare Diseases

ORG_CITY: LA JOLLA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE For the first time a heparan sulfate proteoglycan, SDC-1, has emerged as a regulator of hepcidin and iron metabolism. By evaluating the mechanism by which SDC-1 modulates hepcidin expression and the significance of other hepatic heparan sulfate proteoglycans in relation to hepcidin, new targets for pharmaceutical therapies intended for hepcidin-dysregulated diseases, like anemia of inflammation, will be identified.

PI_NAMEs: LEAL, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: absorption;Address;Affect;Agreement;Anemia;Anemia due to Chronic Disorder;arm;Automobile Driving;BMP6 gene;bone morphogenetic protein receptors;Cell Line;Cell model;Cell Surface Receptors;Cells;Characteristics;Co-Immunoprecipitations;Complex;Cre lox recombination system;CRISPR/Cas technology;crosslink;Data;Diet;dietary;differential expression;Disease;Doctor of Philosophy;Erythrocytes;Evaluation;experimental study;fibroglycan;Functional disorder;Genes;Genetic;Glycocalyx;Goals;Hematological Disease;Hemochromatosis;Hep3B;Heparan Sulfate Biosynthesis;Heparan Sulfate Proteoglycan;Heparitin Sulfate;Hepatic;Hepatocyte;hepatoma cell;hepcidin;HepG2;HFE2 gene;Homeostasis;Human;In Vitro;in vivo;induced pluripotent stem cell;Infection;Inflammation;Inflammatory;insight;Interleukin 6 Receptor;Iron;iron metabolism;Iron Overload;Knock-out;Knockout Mice;Ligands;Liver;Macrophage;Mediating;member;Metabolic;metal transporting protein 1;Modeling;mouse model;Mus;mutant;novel;oxygen transport;Pathologic;Pathway interactions;peptide hormone;pharmacologic;Pharmacologic Substance;Physiological;polyclonal antibody;Polysaccharides;prevent;Primary carcinoma of the liver cells;Production;Proteoglycan;public repository;receptor;Receptor Signaling;Recycling;Regulation;Repression;Risk Reduction;Role;Sample Size;Serum Iron Level;Signal Pathway;Signal Transduction;Structure;syndecan;System;Testing;TFRC gene;Therapeutic;Time;Tissues;Toxic effect;Trace Elements;Training;transcriptome sequencing;Vertebrates

PROJECT_TITLE: Syndecan-1 structure-function analysis in relation to iron metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE The purpose of this mixed methodological study is to conduct a community needs assessment including an evaluation of epidemiological, social, and contextual factors related to overweight and obesity in adolescents (e.g., using population estimates and geospatial mapping) and qualitative data collection methods to gather stakeholder perspectives in a two-part process of 1) obtaining input from stakeholders in the community about barriers and facilitators to existing evidenced-based programs as well as locally developed programs and community resources and 2) reviewing core components of existing scientific evidence to determine fit with community needs and priorities. This project will make a significant and novel public health impact by creating an academic-community partnership (i.e., Young Voices Panel) that will synthesize and integrate current scientific evidence and community input into a prototype of a lifestyle modification intervention for adolescents in Greater Providence, an urban area with substantial racial/ethnic diversity57.

PI_NAMEs: DURKIN, KRISTINE  (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: 19 year old;Address;Adherence;Administrator;Adolescence;Adolescent;adolescent health;Adolescent obesity;Adolescent Risk Behavior;Affect;Age;age related;Atlases;Behavior;Behavior Therapy;Behavioral;behavioral health;Body Weight decreased;Caregivers;Child;Childhood;Clinic;Collaborations;Communities;community academic partnership;community intervention;community organizations;community partners;community setting;concept mapping;contextual factors;Counseling;Data;Data Collection;Data Files;design;Development;Diet;dietary;Dietitian;disadvantaged background;Disparity population;economic disparity;Economics;Environment;Epidemic;Epidemiologic Factors;ethnic diversity;ethnic minority;ethnic minority population;Evaluation;evidence base;Evidence based intervention;Evidence based program;experience;Family;Food;food environment;food insecurity;food security;Food Services;Future;Goals;Government;Health;health care service utilization;health equity promotion;health inequalities;Hospitals;Household;Housing;improved;Incentives;Institution;Intervention;Latino;Life Style Modification;Manuals;Maps;medical specialties;member;Mentored Patient-Oriented Research Career Development Award;Methodological Studies;Methods;minority children;model design;Modification;Monitor;Needs Assessment;Neighborhoods;novel;Nurses;Obesity;obesity development;Obesity Epidemic;Outcome;Overweight;Pattern;pediatrician;Physical activity;physical conditioning;Population;Prevalence;Problem Solving;Process;Program Description;programs;prospective;Protocols documentation;prototype;Public Health;Race;racial minority;racial minority population;Recreation;recruit;Reduce health disparities;Research;Research Personnel;Resources;Rhode Island;Sampling;Schools;social;Social Change;social factors;social health determinants;social norm;social stigma;Social support;Socioeconomic Factors;socioeconomics;stakeholder perspectives;success;Surveys;therapy design;therapy development;tool;United States Department of Agriculture;urban area;Voice;Weight;Youth

PROJECT_TITLE: Incorporating Youth Voices in Community-Based Intervention Development to Improve Diet Quality and Physical Activity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


NIH_SPENDING_CATS: Cancer;Lung

PHR: Project Narrative During the early phase of cancer metastasis to the lung, monocytes are recruited to the lung and differentiate into metastasis-associated macrophages (MAMs). Both monocytes and their progeny MAMs are known to play tumor-supporting roles and exacerbate metastasis in the lung. The goals of this proposal are to identify the signals and factors that influence monocyte differentiation and to define the function of monocytes during their transition into MAMs.

PI_NAMEs: PARK, MINHEE (EMILY)  (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Activated Natural Killer Cell;Affect;Algorithms;assault;Automobile Driving;Bone Marrow;cancer cell;Cause of Death;cell killing;cell type;Cells;Chimera organism;Complement;CSF1 gene;Data;Dendritic Cells;Disseminated Malignant Neoplasm;Distal;effective therapy;Engineering;epigenomic profiling;Family;Floods;Flow Cytometry;Future;Goals;Growth;Hematologic Neoplasms;Hour;Immune;Immune response;Immunity;In Vitro;in vivo;Infiltration;Injections;insight;Knockout Mice;Literature;Lung;Macrophage;Malignant Neoplasms;Mediating;Melanoma Cell;Membrane Proteins;Metastatic Neoplasm to the Lung;Modeling;Molecular;monocyte;multiple omics;Mus;Natural Killer Cells;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;novel therapeutic intervention;novel therapeutics;Organ;Pathway interactions;Patients;Pattern;permissiveness;Phagocytes;Phagocytosis;Phase;Phenotype;Play;prevent;Primary Neoplasm;Process;protein expression;proteomic signature;receptor;recruit;Reporting;residence;response;Role;Signal Induction;Signal Pathway;Signal Transduction;Site;SLAM protein;Solid;Surface;System;Techniques;Testing;Time;Tissues;transcriptomic profiling;Transgenic Mice;tumor;tumor microenvironment;Up-Regulation

PROJECT_TITLE: Differentiation and function of transitional monocytes in cancer metastasis to the lung


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Pulmonary hypertension (PH) related to connective tissue disease-related interstitial lung disease (CTD-ILD) is an understudied and challenging clinical entity with high morbidity and mortality. PH in CTD-ILD may arise through two different mechanisms and manifest as either a parenchymal or vascular phenotype. In this proposed study, I will compare the disease severity and response to treatment of the parenchymal and vascular pheno- types of PH in patients with CTD-ILD.

PI_NAMEs: KHAN, SARAH  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Ablation;Affect;Award;Biological Markers;Blood Vessels;Cardiac;Cardiac Catheterization Procedures;chest computed tomography;Chest imaging;Chronic;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Classification;Clinical;Clinical Research;cohort;Connective Tissue Diseases;Data;Defect;Diagnosis;Disease;Echocardiography;endothelial dysfunction;Enrollment;ethnic diversity;Exclusion;FDA approved;Fibrosis;Foundations;Functional disorder;functional status;Future;hemodynamics;idiopathic pulmonary fibrosis;improved outcome;Individual;Inflammation;Inhalation;Interstitial Lung Diseases;Left;Lung;Measurement;Measures;Mentored Patient-Oriented Research Career Development Award;Morbidity - disease rate;mortality;Myositis;novel;Outcome;outcome prediction;patient population;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phenotype;pro-brain natriuretic peptide (1-76);Prognosis;prognostic;prospective;Publishing;Pulmonary function tests;Pulmonary Hypertension;Quality of life;Quality of Life Assessment;Questionnaires;Recommendation;Registries;Research Design;response;Scleroderma;Serum;Severities;Severity of illness;SPAM1 gene;Staging System;Statistical Data Interpretation;symposium;Symptoms;System;Testing;Therapeutic;Therapeutic Studies;Time;treatment response;Treprostinil;vascular endothelial dysfunction;Walking;women patients;X-Ray Computed Tomography

PROJECT_TITLE: Distinguishing Phenotypes of Pulmonary Hypertension in Patients with Connective Tissue Disease-related Interstitial Lung Disease


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Hematology;Lung;Nutrition;Physical Activity;Precision Medicine;Prevention

ORG_DEPT: MISCELLANEOUS

PHR: Project Narrative In chronic obstructive pulmonary disease (COPD), the third leading cause of mortality worldwide, comorbid diseases and exercise capacity are known independent predictors of morbidity and mortality. While iron level is an important determinant of exercise capacity and plays a vital role in various biologic processes in the lungs, the association between iron deficiency and COPD morbidity is not well known. This proposal seeks to determine whether iron deficiency, a prevalent and treatable condition, is associated with worse COPD morbidity, specifically hospitalization and functional outcomes.

PI_NAMEs: KUNITOMO, YUKIKO  (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Adult;Affect;Age;Anemia;Biological;Biological Process;Blood Banks;Blood specimen;Carrying Capacities;Chronic;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials;cohort;comorbidity;comparative;Complex;data acquisition;Data Analyses;Data Collection;data management;data registry;data repository;Databases;Development;Disease;Disease Outcome;Enrollment;Event;exercise capacity;Exercise Tolerance;experience;Ferritin;Foundations;Functional disorder;functional outcomes;functional status;Future;Heart failure;heart rate monitor;Hemoglobin concentration result;high risk;Home environment;Homeostasis;hospital readmission;Hospitalization;hospitalization rates;Hypoxia;Immune;Impairment;improved;indexing;Individual;Infection;Intravenous;Investigation;Iron;iron deficiency;Iron deficiency anemia;K-Series Research Career Programs;Learning;Lung;Measures;Morbidity - disease rate;mortality;novel;observational cohort study;Observational Study;Oxygen;patient oriented;Patient Self-Report;Patients;personalized medicine;Persons;Physical activity;Physiological;Play;Population;precision medicine;Process;profiles in patients;prospective;pulmonary function;Pulmonary Hypertension;Randomized, Controlled Trials;readmission rates;Recurrence;Research;respiratory;Respiratory Signs and Symptoms;Respiratory Tract Infections;Retrospective Studies;Risk Factors;Role;Sample Size;screening;secondary analysis;secondary outcome;Severities;Spirometry;Symptoms;Telephone;Therapeutic;Tissues;Training;Transferrin;treatment strategy;vasoconstriction;Work

PROJECT_TITLE: The Role of Iron Deficiency in COPD Morbidity