NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Disability Research;Neurodegenerative;Neurosciences

PI_NAMEs: FERRUCCI, LUIGI  (contact)

PROJECT_TERMS: Aging;aging mechanism;Alzheimer's Disease;Baltimore;Biological;Biological Assay;Biological Markers;Biology of Aging;brain volume;Cerebrospinal Fluid;Chronic Disease;cognitive disability;cognitive function;Data;Dementia;Development;Generations;Geroscience;Glial Fibrillary Acidic Protein;Impaired cognition;Impairment;Longitudinal Studies;Magnetic Resonance Imaging;Measures;mild cognitive impairment;Mobility disability;Nerve Degeneration;Older Population;Participant;Pathologic;Pathway interactions;Pattern;Phenotype;Physical Function;physically handicapped;Plasma;Proteins;Proteomics;rate of change;Research Project Grants;Risk;Sampling;Testing;Time;walking speed

PROJECT_TITLE: ALZHEIMER'S RESEARCH PROJECT: Implementation of a longitudinal proteomic profile in the BLSA


ACTIVITY: ZIA

ADMINISTERING_IC: HD

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

PI_NAMEs: PERKINS, NEIL  (contact)

PROJECT_TERMS: Address;Affect;Age;aged;Alcohol consumption;Anovulation;Attention;Behavioral;Biological;Biological Markers;cardiometabolism;Chronic Disease;cigarette smoking;Data;design;Diet;Dietary Factors;disorder risk;Environmental Epidemiology;Estrogens;Exercise;Failure;follow-up;Functional disorder;Goals;Gonadal Steroid Hormones;Health;high risk;Hormonal;Hormones;Impairment;Influentials;insight;Intake;interest;Life Style;Longitudinal cohort study;Luteal Phase;Menstrual cycle;Menstruation;Metabolism;nutritional epidemiology;Oxidative Stress;Paper;Periodicity;Physiological;Premenopause;Premenstrual syndrome;prospective;Public Health;Publishing;reproductive;reproductive hormone;Research;Role;social epidemiology;Symptoms;Variant;Vegetable Proteins;Vitamin D;Woman;Women's Health

PROJECT_TITLE: Oxidative Stress, Hormones and Women s Health


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Infertility;Maternal Health;Pediatric;Pregnancy;Prevention;Women's Health Research

ORG_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

PROJECT_TERMS: Accounting;aged;Aspirin;Blood flow;Cannabis;Characteristics;cohort;Conceptions;disorder prevention;Dose;Double-Blind Method;Exposure to;failure Implantation;Fertility;Fetal Death;Gestational Age;Goals;Home;Human;implantation;improved;Infertility;Inflammation;Link;Live Birth;Menstrual cycle;Menstruation;Monitor;Opioid;Participant;Placebos;Pregnancy;Pregnancy Complications;Pregnancy Histories;Pregnancy loss;Pregnancy Outcome;Pregnancy Tests;pregnant;prevent;primary outcome;prospective;Protocols documentation;Publishing;Randomized;randomized trial;Recording of previous events;Reproduction;reproductive outcome;secondary outcome;Selective Serotonin Reuptake Inhibitor;Site;Spontaneous abortion;subfertility;Time;treatment effect;trial design;Woman;Work

PROJECT_TITLE: EAGeR Trial - The Effects of Aspirin in Gestation and Reproduction Trial


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: LIU, PAUL  (contact)

PROJECT_TERMS: Acute Myelocytic Leukemia;Address;Adult Acute Myeloblastic Leukemia;Affect;Affinity;Animal Model;Attenuated;Binding;Biological Markers;Biological Process;Bone Marrow Cells;C-terminal;CBFB gene;CBFbeta-MYH11 fusion protein;Cells;Chemicals;Childhood Acute Lymphocytic Leukemia;Chromosome abnormality;clinical center;clinical practice;Clinical Research;Collaborations;Communities;Core-Binding Factor;Data;Development;Diagnosis;differential expression;Disease;DNA;DNA Binding;DNA Methylation;Erythrocytes;fusion gene;Gene Expression;Gene Mutation;Genes;Genetic;genetic approach;Genomic approach;genomic tools;Genomics;Goals;Hematological Disease;Hematopoiesis;Homeostasis;Hypermethylation;improved;Interferometry;Intramural Research Program;Length;leukemia;leukemia treatment;leukemogenesis;Manuscripts;Methylation;methylome;Molecular;Monitor;mouse model;Mus;Mutation;Myeloid Cells;Myeloid Progenitor Cells;MYH11 gene;National Center for Advancing Translational Sciences;National Human Genome Research Institute;Ontology;Pathogenesis;Patients;Play;Preleukemia;Preparation;Prognosis;promoter;Proteins;Proto-Oncogene Protein c-kit;Reporting;Residual Neoplasm;Resources;Role;RUNX1 gene;Scientist;Site;Technology;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Transgenic Animals;Translating;translational study;tumorigenesis;United States National Institutes of Health;Variant;Vertebrates;Wild Type Mouse;Zebrafish

PROJECT_TITLE: Mechanistic and translational studies of CBF leukemia


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Hematology;Human Genome;Rare Diseases

ORG_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

PROJECT_TERMS: Address;Affect;Animal Model;Applications Grants;aspirate;autosome;Biological Assay;Biological Markers;biomarker identification;Bleeding time procedure;Blood Cells;Bone marrow biopsy;Books;CBFbeta-MYH11 fusion protein;Clinical;clinical center;clinical phenotype;Clinical Research;Clonal Evolution;Coagulation Process;cohort;Collaborations;Consultations;Cytogenetic Analysis;Defect;Development;Diagnosis;Diagnostic;Disease;Disease Outcome;Disease Progression;Educational process of instructing;Enrollment;epigenomics;Evaluation;exome sequencing;experience;Familial Platelet Disorder;Family;Family member;Funding;fusion gene;Gene Expression;Gene Mutation;Genes;Genetic;genetic approach;Genomic approach;genomic tools;Genomics;Genotype;Germ Lines;Germ-Line Mutation;Goals;Grant;Hematologic Neoplasms;Hematopoiesis;Hematopoietic Neoplasms;hematopoietic tissue;Individual;Innovative Therapy;Institution;Journals;Knowledge;Laboratory Research;leukemia;leukemogenesis;longitudinal, prospective study;Malignant - descriptor;Malignant Neoplasms;Medical;Medical History;Megakaryocytes;Molecular;Monitor;mutant;Mutation;Mutation Detection;Myeloproliferative disease;Natural History;Office Visits;Participant;participant enrollment;Pathogenesis;Pathogenicity;Patients;Peer Review;Penetrance;peripheral blood;Phenotype;Platelet Count measurement;platelet function;Predisposition;Privatization;Procedures;Process;prospective;Prospective Studies;Publishing;Rare Diseases;Research;Research Subjects;Risk;RUNX1 gene;Sample Size;Severity of illness;single-cell RNA sequencing;SNP array;Somatic Mutation;Specialist;Syndrome;Techniques;Technology;Testing;transcriptome sequencing;Transgenic Animals;translational study;tumorigenesis;United States National Institutes of Health;Visit;Work

PROJECT_TITLE: Clinical and translational studies of RUNX1 and FPDMM


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Biotechnology;Brain Disorders;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetic Testing;Genetics;Human Genome;Mental Health;Neurosciences;Orphan Drug;Ovarian Cancer;Precision Medicine;Prevention;Rare Diseases;Women's Health Research

PI_NAMEs: ELNITSKI, LAURA L (contact)

PROJECT_TERMS: Address;Alternative Splicing;angiogenesis;Anterior;Apoptosis;Area;aspirate;Attention;Attention deficit hyperactivity disorder;Automobile Driving;Base Sequence;Biological;Biological Markers;Biological Process;Biology;biomarker evaluation;Blood;BRAF gene;CA-125 Antigen;cancer biomarkers;Cancer cell line;Cancer Detection;cancer type;Carcinoma;Cell Nucleus;cell type;Cells;Cellular Stress;Characteristics;Chromatin;cingulate cortex;Clinical;clinically relevant;Code;cohort;Collaborations;Colon Carcinoma;Complex;computational pipelines;Computing Methodologies;Corpus striatum structure;CpG Island Methylator Phenotype;Data;detection assay;Development;Diagnostic;diagnostic biomarker;differential expression;Disease;disease model;disease phenotype;Distal;Distant;DNA;DNA Methylation;DNA Sequence Alteration;Down-Regulation;Early Diagnosis;Elements;Endometrioid Tumor;Enhancers;Epigenetic Process;epigenetic regulation;Epithelial ovarian cancer;Epithelium;ESR1 gene;Event;Exhibits;experimental study;Fostering;Future;FYN gene;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic;Genome;genomic data;Genomic medicine;Genomics;Genotype;Glutamates;Goals;Health;Healthcare;Human;human disease;Human Genome;human genome sequencing;immune cell infiltrate;Initiator tRNA;innovation;insight;Intervention;Invaded;Investigation;knock-down;Knowledge;Link;Logistic Regressions;loss of function;machine learning classifier;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;Manuscripts;Measures;Medical;Melanoma;Mendelian disorder;Mesenchymal;Methodology;Methylation;methylation biomarker;Modeling;Modification;Molecular;Molecular Sieve Chromatography;molecular subtypes;Mutate;Mutation;Neoplasm Metastasis;Neurodevelopmental Disorder;neuronal cell body;Neurotransmitters;Non-Invasive Cancer Detection;novel;novel strategies;novel therapeutic intervention;nucleolin;Oncogenes;Open Reading Frames;Outcome;Ovarian;ovarian neoplasm;Pathogenesis;Pathway interactions;Patients;personalized health care;Phenotype;Phosphotransferases;Point Mutation;Preparation;prevent;Primary Neoplasm;Principal Component Analysis;Process;programs;Proliferating;promoter;Protein Isoforms;Protein Tyrosine Kinase;Proteins;Receptor Protein-Tyrosine Kinases;Regulation;Regulator Genes;Regulatory Element;Reporting;Research;response;RNA Splicing;RNA-Binding Proteins;Role;Sampling;Science;Screening for cancer;Screening for Ovarian Cancer;Serous;Site;small molecule;Solid;Somatic Mutation;Specificity;Subgroup;Testing;The Cancer Genome Atlas;Therapeutic;Therapeutic Intervention;therapeutic target;therapeutically effective;Tissue-Specific Gene Expression;trait;Transcript;transcriptome;transcriptomics;Treatment Efficacy;treatment planning;tumor;Tumor Biology;tumor diagnostic;tumor DNA;Tumor Suppressor Genes;Untranslated RNA;Uterus;Validation;Variant;Work

PROJECT_TITLE: Regulatory and epigenetic landscapes reveal biological processes, disease mechanisms and diagnostic markers


ACTIVITY: ZIC

NIH_SPENDING_CATS: Infectious Diseases;Pediatric;Pregnancy;Women's Health Research

PI_NAMEs: WECK, JENNIFER  (contact)

PROJECT_TERMS: Address;Alabama;Best Pharmaceuticals for Children Act;biobank;Biological Assay;Biological Specimen Banks;Calcium;Childhood;Clinical Research;Communicable Diseases;Contracts;Data;data sharing;Dedications;Diabetes Mellitus;Ensure;experience;Extramural Activities;Fetal Growth;Goals;Guidelines;Human Resources;Longitudinal Studies;Maternal-Fetal Medicine Units Network;National Institute of Child Health and Human Development;Norway;Obstetric pharmacology;pediatric pharmacology;Perinatal;Perinatology;population health;Pre-Eclampsia;Pregnancy;premature;Prevention trial;Procedures;Program Development;programs;repository;Research;Research Design;Research Personnel;research study;Resources;Services;Source;Specimen;Testing;Therapeutic;United States National Institutes of Health;Vagina;vaginal infection;Vision;Women's Health;Work

PROJECT_TITLE: Biospecimen Repository - Division of Intramural Population Health Research


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Hematology;Human Genome;Pediatric;Pediatric Cancer;Primary Immunodeficiencies;Rare Diseases

PI_NAMEs: CHANDRASEKHARAPPA, SETTARA  (contact)

PROJECT_TERMS: Acute Myelocytic Leukemia;Attention deficit hyperactivity disorder;bead chip;Blood capillaries;bone marrow failure syndrome;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Coloboma;Colorectal Cancer;Communication;Communities;Computer software;congenic;congenital heart abnormality;Consultations;Copy Number Polymorphism;CRISPR/Cas technology;Data;data access;Data Analyses;Data Set;deletion detection;design;Diagnosis;Diamond-Blackfan anemia;DNA;Dyskeratosis Congenita;Epilepsy;Evaluation;Eye diseases;Fanconi's Anemia;Fever;Genetic;Genome;genome-wide;Genomic Segment;Genomics;Genotype;Haplotypes;Head and Neck Cancer;Human;Human Cell Line;human DNA;identity by descent;induced pluripotent stem cell;Infection;Inherited bone marrow failure;insertion/deletion mutation;interest;Kidney Diseases;large datasets;Learning;Leber's amaurosis;Ligation;Linkage Disequilibrium;Loss of Heterozygosity;Malignant Breast Neoplasm;Malignant Neoplasms;meetings;Methylation;Mosaicism;Mus;Mutagenesis;mutation screening;National Human Genome Research Institute;National Institute of Allergy and Infectious Disease;National Institute of Mental Health;Oculocutaneous Albinism;Parents;Patients;population stratification;Problem Solving;Process;programs;Research;Research Personnel;research study;Resources;Running;Sampling;service utilization;Services;Smith Magenis syndrome;SNP array;SNP genotyping;Speed;Syndrome;Technology;tool;United States National Institutes of Health;Update;Variant;Zebrafish;zinc finger nuclease technology

PROJECT_TITLE: NHGRI/DIR Genomics Core


NIH_SPENDING_CATS: Aging;Bioengineering;Genetics;Human Genome;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

PI_NAMEs: WINCOVITCH, STEPHEN  (contact)

PROJECT_TERMS: 3-Dimensional;Abbreviations;Age;Agglutinins;Aging;Alleles;Architecture;Area;Axon;axon guidance;Binding;Biological Assay;Brain;Cardiac;Cell Line;Cell Nucleus;Cells;Cellular Morphology;Cerebellum;Cessation of life;Charge;charge coupled device camera;Child;Clinical Management;Collaborations;Communities;Complex;Computer software;Computer Workstations;computerized tools;confocal imaging;Confocal Microscopy;Core Facility;Cytoplasm;Data;design;Development;Disease;disease-causing mutation;Engineering;Equipment;Excision;experimental study;Familial Platelet Disorder;Fatigue;fluorescence imaging;Fluorescence Recovery After Photobleaching;Fluorescence Resonance Energy Transfer;Four-dimensional;Future;Gaucher Disease;Genes;genetic risk factor;Genotype;Germ Lines;glucosylceramidase;glycosylation;Goals;Green Fluorescent Proteins;Growth;Heart;Heterozygote;Histopathology;Hour;Image;Image Analysis;imager;imaging study;Immunofluorescence Immunologic;In Vitro;Individual;induced pluripotent stem cell;influenza infection;interest;Investigation;investigator training;Knock-in Mouse;Knock-out;Knockout Mice;Laser Scanning Confocal Microscopy;Lasers;Lead;Lectin;Libraries;Link;live cell imaging;Lung;Lysosomes;Maackia amurensis;Measures;Melanins;melanocyte;Melanosomes;Microscope;Microscopy;Minority;Mission;Molecular;Morphology;mouse model;Mus;Mutation;myelination;Myocardial Infarction;National Human Genome Research Institute;National Institute of Neurological Disorders and Stroke;Natural History;Nerve;Nerve Degeneration;nervous system development;neural;Neurodegenerative Disorders;Neurons;novel;novel therapeutics;Nuclear;Oculocutaneous Albinism;Optics;Organelles;Parkinson Disease;Pathogenicity;Pathologic;Patients;Pattern;Peanut Agglutinin;Pharmaceutical Preparations;Phenotype;photoactivation;Principal Investigator;Process;Progeria;progressive neurodegeneration;Protein translocation;Protocols documentation;Purkinje Cells;Reagent;Reporter;Research;Research Personnel;Research Project Grants;Resolution;response;Running;RUNX1 gene;Sambucus nigra;Scanning;screening;Services;Sialic Acids;Siblings;Slide;spatiotemporal;Stains;Stimulus;Stroke;Structure;Structure of parenchyma of lung;Subcellular structure;superresolution microscopy;Syndrome;System;Techniques;Technology;Teenagers;temporal measurement;Time;Tissues;Training;Transfection;two-dimensional;ultra high resolution;Variant;variant of unknown significance;Vesicle;Visualization

PROJECT_TITLE: NHGRI Advanced Imaging & Analysis Core


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

PI_NAMEs: ANDERSON, STACIE  (contact)

PROJECT_TERMS: Cell Size;cell type;Cells;cellular engineering;Classification;Color;design;Development;Equipment;experimental analysis;experimental study;Flow Cytometry;Genes;genome editing;Genomics;Goals;Human Resources;instrument;Lasers;magnetic cell separation;Measures;Mus;National Human Genome Research Institute;particle;Population;Research;Research Personnel;Running;Sampling;Services;Surface;Suspensions;Technology;tool;Training

PROJECT_TITLE: NHGRI/DIR Flow Cytometry Core


PI_NAMEs: ELKAHLOUN, ABDEL  (contact)

PROJECT_TERMS: Cells;Computer software;Copy Number Polymorphism;Core Facility;cost effective;Data;Data Analyses;data mining;data quality;DNA Library;Gene Expression Profile;Generations;Genome;Genomics;Goals;Label;Link;Methylation;MicroRNAs;Mining;National Human Genome Research Institute;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;Output;Protocols documentation;Quality Control;Reagent;Research Personnel;Resources;RNA;Sampling;Services;single cell genomics;single cell sequencing;single-cell RNA sequencing;Summary Reports;Suspensions;Technology;Time;Training;transcriptome sequencing;transcriptomics

PROJECT_TITLE: NHGRI/DIR Microarray and single-cell Core


ACTIVITY: ZID

NIH_SPENDING_CATS: American Indian or Alaska Native;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Patient Safety;Racial and Ethnic Minority Health Research

PI_NAMEs: HULL, SARA  (contact)

PROJECT_TERMS: Accreditation;Address;adjudication;Adult;Alaska;Authorship;Award;base;Bioethics;Brain;Case Study;case-by-case basis;Certification;Charge;Childhood;Clinical;clinical center;Clinical Practice Guideline;Clinical Protocols;Clinical Research;Clinical Research Protocols;Clinical Trials Data Monitoring Committees;Collaborations;Conflict of Interest;Consent;Consent Forms;Consult;Consultations;Data;data management;data sharing;Descriptor;design;Development;Disparate;diversity and equity;Education;education research;Educational process of instructing;Educational workshop;Employee;Enrollment;Ensure;Ethical Issues;Ethical Review;ethical, legal, and social implication;Ethicists;Ethics;Ethics Committees;Ethics Consultation;Ethnic equity;Evaluation;Event;Exclusion;Extramural Activities;Focus Groups;Fostering;Funding;genomic data;Genomics;Good Clinical Practice;health disparity;health equity;Human;human data;human subject;Human Subject Research;Indigenous;indigenous community;Institution;Institutional Review Boards;Instruction;Internships;Intramural Research;Intramural Research Program;Knowledge;Lead;Leadership;Learning;Maintenance;Manuscripts;material transfer agreement;Medical Genetics;Medicine;meetings;member;Mentors;Minor;Mission;Modeling;Modification;National Heart, Lung, and Blood Institute;National Human Genome Research Institute;pandemic disease;Participant;Persons;Policies;Population;Postbaccalaureate;Postdoctoral Fellow;Procedures;Process;programs;Protocol Compliance;Protocols documentation;Publishing;Racial Equity;recruit;repository;Research;Research Activity;Research Ethics;Research Misconduct;Research Personnel;Research Project Grants;Research Support;Research Training;responsible research conduct;Review Committee;Services;symposium;System;Techniques;Technology Transfer;Training;Training Activity;Transfer Agreement;tribal health;Tribes;Trust;United States Indian Health Service;United States National Institutes of Health;Vulnerable Populations;Work;working group;Writing

PROJECT_TITLE: NHGRI/DIR Bioethics Core


ACTIVITY: ZIE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetic Testing;Genetics;Health Services;Human Genome;Prevention;Primary Immunodeficiencies;Rare Diseases;Telehealth;Women's Health Research

PI_NAMEs: ERBY, LORI  (contact)

PROJECT_TERMS: Address;Adoption;Adult;Advocacy;Age;Arrhythmogenic Right Ventricular Dysplasia;Behavior;Belief;Benefits and Risks;Biological;Black race;cancer genetics;Characteristics;Child;Client;Client satisfaction;Clinical;Clinical Management;Clinical Trials;Code;cohort;Collaborations;Communication;Communities;community involvement;Complication;Confusion;congenital immunodeficiency;coping;cost;Cross-Sectional Studies;CTLA4 haploinsufficiency;Data;Decision Making;Development;Diagnosis;Disclosure;Disease;education resources;eligible participant;Ethics;European;Evaluation;Exhibits;expectation;experience;faculty research;Family;Feeling;Future;gain of function;GATA2 deficiency;gene therapy;gene therapy clinical trial;Genetic Counseling;genetic counselor;genetic disorder diagnosis;Genomics;Guide prevention;Guilt;Health;health disparity;Hour;Human;Imagination;Individual;Industry;Informed Consent;Institution;interest;Intervention;Interview;Judgment;Knowledge;Learning;Length;Life;Linear Regressions;Logistic Regressions;Master of Science;Measures;Mediation;Methods;Modeling;National Cancer Institute;National Human Genome Research Institute;Nature;non-verbal;Nonverbal Communication;Oncology;Paper;Participant;patient oriented;Patient-Centered Care;Patients;Pattern;Penetrance;Perception;Persons;Policies;polygenic risk score;Population;Practice Guidelines;Precision Health;Preparation;Prevention strategy;Process;programs;prophylactic mastectomy;Public Health;Public Health Schools;Publications;Publishing;Questionnaires;Race;randomized trial;Recommendation;Relationship-Building;Relative Risks;reproductive;Reproductive Technology;Research;Research Personnel;Resources;response;Risk Assessment;Risk Management;Rotation;Roter;Sampling;satisfaction;Scholarship;screening;Services;Severities;Severity of illness;Shame;Shapes;Slice;social;Societies;standard of care;Standardization;Students;Systems Analysis;telehealth;theories;Therapeutic;Therapeutic Studies;Thinness;Training;Training Programs;Transcript;trial enrollment;Trust;Uncertainty;United States National Institutes of Health;Universities;verbal;Verbal Behavior;video coaching;Work

PROJECT_TITLE: NHGRI/DIR Genetic Counseling Training Program


ACTIVITY: ZII

PI_NAMEs: KING, SARA  (contact)

PROJECT_TERMS: Address;Affinity;Collaborations;Core Facility;Databases;Fostering;Goals;interest;Intramural Research;Laboratories;Laboratory Research;Liquid substance;Location;Maps;Maryland;multidisciplinary;Regulation;Research;Research Personnel;Resource Sharing;Science;Scientist;United States National Institutes of Health;Update;Work

PROJECT_TITLE: Space Renovations, Activation, and Commissioning


ACTIVITY: ZIJ

PI_NAMEs: BOHN, MEGAN  (contact)

PROJECT_TERMS: Academic support;Accreditation;Address;Affinity;Applications Grants;Area;Arts;Award;Awareness;Biology;Biomedical Research;Bone Diseases;Brazil;career;career development;Career Mobility;career networking;Clinical;cohort;Collaborations;college;Communication;Databases;Development;Development Plans;editorial;Education;Educational process of instructing;Educational workshop;Evaluation;experience;Exposure to;Extracellular Matrix;Fellowship;France;Funding;Funding Mechanisms;Funding Opportunities;Future;Gene Expression Regulation;Genetic Diseases;Goals;graduate student;Grant;health disparity;health equity;Health equity research;high school;improved;Incentives;Individual;Institution;Interview;Intramural Research;Job Application;Laboratories;Learning;Maintenance;medical schools;Medical Students;Medicine;member;Mentors;National Center for Advancing Translational Sciences;National Heart, Lung, and Blood Institute;National Human Genome Research Institute;National Institute of Allergy and Infectious Disease;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;National Institute of Child Health and Human Development;National Institute of Dental and Craniofacial Research;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of Environmental Health Sciences;National Institute of Neurological Disorders and Stroke;National Institute on Deafness and Other Communication Disorders;Newsletter;Occupational Therapy;Occupations;outreach;Policy Developments;Population;post-doctoral training;Postbaccalaureate;Postdoctoral Fellow;posters;Process;Program Development;programs;Progress Reports;Public Health;Publishing;recruit;Reporting;Research;Research Personnel;Research Project Grants;Resources;Rotation;Running;Scholars Program;Schools;Science;Scientist;Series;Services;Site Visit;skills;Students;summer internship;Surveys;System;Talents;tenure track;Training;Training and Education;Training Programs;undergraduate student;United States National Institutes of Health;Universities;university student;Update;virtual;Visit;Vocational Guidance;webinar;Work;Writing

PROJECT_TITLE: NICHD Office of Education


ADMINISTERING_IC: FD

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: HOUGHTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_FIPS: US

ORG_NAME: MICHIGAN TECHNOLOGICAL UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative This project will create a continuous manufacturing process for a highly effective influenza vaccine. The novel process will reduce the cost of building a new manufacturing plant and reduce the cost to run the plant. Once production begins, the vaccine can easily be updated so that the vaccine will better match the circulating influenza strains and thus better protect the public from influenza.

PI_NAMEs: BETENBAUGH, MICHAEL J;HELDT, CARYN  (contact)

PROGRAM_OFFICER_NAME: OSORIO, MANUEL

PROJECT_TITLE: Integrated and Continuous Manufacturing of an Influenza Vaccine


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Women's Health Research

ORG_CITY: ROCKVILLE

ORG_NAME: WESTAT, INC.

ORG_STATE: MD

PI_NAMEs: MONTALVAN, REBECCA  (contact)

PROJECT_TERMS: Address;Area;Artificial Intelligence;authority;Award;Behavioral;Biological Process;Biomedical Research;catalyst;Chronic lung disease;Clinical;Clinical Data;Collaborations;Data;Data Set;database of Genotypes and Phenotypes;Dedications;Disease;Disparity;Ecosystem;Environmental Exposure;Exhibits;experience;Familiarity;Gender;genome sequencing;Health;Heart Diseases;Hematological Disease;idiopathic pulmonary fibrosis;Image;improved;Infrastructure;innovation;interest;Internet;Intervention;Lung Diseases;Machine Learning;machine learning method;Measures;Medical;Medical Imaging;Methods;Molecular;National Heart, Lung, and Blood Institute;Nature;novel;operation;organizational structure;Outcome;petabyte;Phenotype;Positioning Attribute;Precision Medicine Initiative;Prevention;Procedures;Process;programs;Progress Reports;Radiogenomics;radiomics;Research;Research Institute;Research Personnel;Research Project Grants;Research Proposals;Research Subjects;Risk Factors;Role;Running;sex;Sex Differences;Sleep Disorders;Structure;success;synergism;System;Therapeutic;Time;Trans-Omics for Precision Medicine;Update;whole genome;Woman;Women's Health;Work

PROJECT_TITLE: Trans-Omics for Precision Medicine (TOPMed) Artificial Intelligence Coordinating Center (AI-CC)


ADMINISTERING_IC: ES

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Natural Products;Prevention;Social Determinants of Health

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: INTEGRATED LABORATORY SYSTEMS, LLC

ORG_STATE: NC

PI_NAMEs: HOBBS, CHERYL A. (contact)

PROJECT_TERMS: Adopted;Adult;Adverse effects;aging process;Animal Model;Animal Testing;Animals;Biological;Biological Assay;Biological Monitoring;Biotechnology;Birth;Blood specimen;Botanicals;Brain;carcinogenicity;Carcinogens;Cells;Chemical Exposure;Chemicals;Clinic;Clinical;Clinical Research;Colon;Comet Assay;Complication;Congenital Abnormality;contaminated water;Contracts;Data;Development;Diagnosis;dietary supplements;Disasters;Disease;DNA Damage;DNA sequencing;Early Diagnosis;early life exposure;Economics;Environment;environmental chemical;Environmental Exposure;Erythrocytes;Event;Evolution;exposed human population;Exposure to;Family suidae;flexibility;Frequencies;Future;Gene Expression;Gene Mutation;Generations;Genes;Genetic;Genetic Induction;Genomics;genotoxicity;Guidelines;Health;Human;human study;In Vitro;in vitro testing;in vivo;Induced Mutation;innovation;interest;International;Kidney;Laboratories;Life;Link;Liver;Malignant Neoplasms;Mammalian Cell;Methods;micronucleus;Micronucleus Tests;Mission;Monitor;multiplex assay;Mus;Mutagenicity Tests;Mutation;mutation assay;Mutation Detection;Mutation Spectra;National Institute of Environmental Health Sciences;novel strategies;Oncology;Outcome;Participant;peripheral blood;Pesticides;Pharmaceutical Preparations;Pharmacologic Substance;Phenotype;Protocols documentation;Rattus;Resources;response;Rodent;Sampling;Source;Stomach;Study models;Symptoms;System;Technology;Testing;Tissues;Toxic effect;Toxicity Tests;Toxicogenetics;Toxicology;Translating;treatment response;tumor;United States Environmental Protection Agency;United States Food and Drug Administration;Update;West Virginia

PROJECT_TITLE: GENETIC TOXICOLOGY SUPPORT FOR THE NTP AND THE NIEHS


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Services;Tobacco;Tobacco Smoke and Health

ORG_CITY: FAIRFAX

ORG_NAME: ICF, INC., LLC

ORG_STATE: VA

PI_NAMEs: KILGORE, ELIZABETH  (contact)

PROJECT_TERMS: Adoption;Awareness;behavioral health;Communication;Communities;Community Health;Contractor;Development;Division of Cancer Control and Population Sciences;Equipment;Future;Government;Government Agencies;Health Services;Human Resources;improved;insight;Measures;mhealth interventions;National Cancer Institute;outreach;Population Group;Public Health;Qualifying;Research;Research Institute;Research Support;Services;smoking cessation;tool;Work

PROJECT_TITLE: INTERNAL AND EXTERNAL COMMUNICATIONS AND DISSEMINATION SUPPORT FOR DCCPS


ADMINISTERING_IC: IP

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CENTER FOR IMMUNIZATION AND RESPIRATORY DISEASES

ORG_CITY: ANN ARBOR

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE This research study will use economic survey methods to collect data on public/parent/patient preferences for vaccine outcomes and vaccination programs. Using this information, the CDC will be better able to measure the value of future vaccination programs and to design strategies to increase uptake of vaccination.

PI_NAMEs: PROSSER, LISA A. (contact)

PROJECT_TITLE: RFA-IP-23-007, Collaborative Surveys to Provide Inputs into Vaccine-Related Economic Evaluations


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Microbiome

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative  Adenomas are early lesions of colorectal cancer (CRC), but only a subset of individuals develop adenomas, and only a subset of adenomas progress to cancer. We hypothesize that adenoma development and progression require adenoma autonomous factors (e.g. cancer driver gene mutations) in concert with adenoma nonautonomous factors pertaining to the gut microbial microenvironment. Our proposed studies will examine the direct causal relationships and interactions of adenomas, the colonic microenvironment, and the gut microbiome as “co-conspirators” of adenoma initiation and/or progression.

PI_NAMEs: DEY, NEELENDU  (contact)

PROGRAM_OFFICER_NAME: PATRIOTIS, CHRISTOS F

PROJECT_TERMS: adenoma;Architecture;Automobile Driving;Basic Science;Behavior;Cells;Colon;Colonoscopy;Colorectal;Colorectal Adenoma;Colorectal Cancer;Data;deep sequencing;Development;Fibroblasts;Gene Mutation;Genetic;Gnotobiotic;gut bacteria;gut microbiome;Human;Image;In Situ;Individual;individualized prevention;Indolent;insight;Knowledge;Lesion;Link;Longitudinal cohort;Machine Learning;Malignant Neoplasms;Mediating;Mediation;Metagenomics;microbial;microbiome;Modeling;Molecular;Molecular Profiling;Monitor;Mus;novel;Oncogenic;Organoids;Role;screening;senescence;senescence associated secretory phenotype;Testing;Tissues;Translations;tumorigenesis;tumorigenic

PROJECT_TITLE: The gut microbiome, interactions with primed colon states, and effects on adenoma formation and progression


NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Microbiome;Prevention;Racial and Ethnic Minority Health Research

PHR: Project Narrative  The Alaska Native community faces a high burden of colorectal cancer (CRC), with the highest incidence and mortality rates in the US. This study aims to investigate the link between the gut microbiome and colorectal adenomas, the early precancerous lesions in CRC, specific to this population. Through microbiome profiling of  unique collections of fecal samples, we will identify gut microbial biomarkers for colorectal adenomas.

PROJECT_TERMS: Address;adenoma;Administrative Supplement;Alaska Native;Alaska Native population;Architecture;Automobile Driving;Biological Markers;Biology;Cancer Center;cancer health disparity;carcinogenicity;cohort;Collection;Colon;Colonoscopy;Colorectal;Colorectal Adenoma;Colorectal Cancer;colorectal cancer risk;Communities;Data;Death Rate;Deoxycholic Acid;Disparity;Face;Geography;gut microbiome;high risk;improved;Incidence;individualized prevention;Intervention;Investigation;Lesion;Link;metabolomics;Metagenomics;microbial;microbiome;Population;premalignant;prevent;Publishing;Redwood;Reporting;Research;screening;stool sample;Tissues;tribal health


NIH_SPENDING_CATS: Cancer

PI_NAMEs: GRADY, WILLIAM MALLORY (contact)

PROJECT_TITLE: Administrative Core


ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: PROJECT NARRATIVE  Patients who have cancer that has spread to distant sites in the body have a poor prognosis. Macrophages are  a type of cell that surrounds the cancer and supports its growth. We will understand how these macrophages  enable cancers to grow in other organs in the body and test treatments against them.

PI_NAMEs: KAMM, ROGER D (contact)

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: 3-Dimensional;Biological Models;Blood - brain barrier anatomy;Blood Vessels;Cause of Death;cell type;Cells;checkpoint therapy;Clustered Regularly Interspaced Short Palindromic Repeats;Colon Carcinoma;colorectal cancer metastasis;Distant;Extracellular Matrix;Fibroblasts;Genetic Markers;Growth;Human;Imaging Techniques;Immune;in vivo;Invaded;Knock-out;Macrophage;Malignant Neoplasms;metastatic colorectal;Metastatic malignant neoplasm to brain;Microfluidic Microchips;Microfluidics;Microscopy;migration;Modeling;Neoplasm Metastasis;neoplastic cell;neutralizing antibody;Organ;Patients;physiologic model;Physiological;Pirfenidone;pressure;Process;Prognosis;Proliferating;Role;shear stress;Site;small molecule;Testing;Therapeutic Intervention;Tumor Cell Invasion;tumor microenvironment;Tumor Promotion;Tumor-associated macrophages;tumorigenic

PROJECT_TITLE: Project1: The role of intravascular pressure and shear stress on tumor cell arrest, survival and proliferation in the microvascular niche


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Networking and Information Technology R&D (NITRD);Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PI_NAMEs: BARNHART, KURT T (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: 3-Dimensional;Adult;Anatomy;annotation  system;Atlases;Biological Assay;Body System;Cardiovascular Diseases;cell community;Cells;Cellular biology;Chromatin;Chromium;Clinical;Collaborations;Communities;Computer software;Data;Data Analyses;Data Collection;data standards;Deposition;digital models;embryo/fetus;Endocrine;Endocrine System Diseases;Endometrium;Ensure;Environment;Epigenetic Process;Female;female reproductive system;Fertilization;Fetus;Generations;Geography;Germ Cells;Goals;Gonadal Steroid Hormones;granulosa cell;Health;Home;Human;Human BioMolecular Atlas Program;Human body;Image;implantation;In Situ;indexing;Informatics;Life;life span;Location;Longevity;Maintenance;Malignant Neoplasms;Mammalian Oviducts;Maps;Medical Records;Metadata;Methods;Modality;Molecular;molecular scale;mortality;natural Blastocyst Implantation;Oocytes;Organ;Ovary;Periodicity;Personal Satisfaction;Population;Procedures;Process;Production;Proteins;Protocols documentation;Records;Reproduction;reproductive;Reproductive Biology;reproductive organ;Resources;RNA;sample collection;Sampling;Scheme;single-cell RNA sequencing;Stromal Cells;Structure;structured data;theca cell;three-dimensional modeling;Time;Tissue Sample;Tissues;Uterus;Validation;Walking;Women's Health;Work

PROJECT_TITLE: Penn TMC: Organ-Specific Project


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: HADLEY

ORG_NAME: VENTUREWELL

PI_NAMEs: NEAL, REBEKAH ANNE (contact)

PROJECT_TERMS: Acceleration;COVID-19 diagnostic;Diagnostic tests;FDA Emergency Use Authorization;programs;RADx;RADx Tech;research clinical testing;Services;United States National Institutes of Health

PROJECT_TITLE: RAPID ACCELERATION OF DIAGNOSTICS (RADX) CLINICAL EVALUATION SERVICES -TASK ORDER 06


ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE We have determined that histotripsy, a novel technology that ablates tumors precisely and non-invasively using high intensity ultrasound waves, triggers a sequence of cell death events in treated and distant, untreated tumors that culminate in a systemic anti-tumor immune response that is stronger than that generated by existing modes of tumor ablation. We will examine three distinct cellular events that follow histotripsy ablation – the exposure of contents hidden inside tumor cells, the triggering of inflammatory cancer cell suicide of cancer cells, and immune cell-driven cancer cell death – to determine the extent to which these unique events mechanistically drive the phenomenon of histotripsy immunostimulation. By understanding these events and testing preclincal strategies to harness and maximize them, we hope to establish a scientific foundation for implementing histotripsy tumor ablation as a means of maximizing the impact of cancer immunotherapy.

PI_NAMEs: CHO, CLIFFORD  (contact)

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: Ablation;Abscopal effect;adaptive immune response;adaptive immunity;anti-tumor immune response;Antigen-Presenting Cells;Antigens;Attention;cancer cell;cancer immunotherapy;carcinogenesis;CD8-Positive T-Lymphocytes;Cell Communication;Cell Death;cell killing;cell suicide;Cells;Cessation of life;checkpoint inhibition;Clinical;clinical practice;clinically relevant;Colon Carcinoma;cytotoxicity;Data;Detection;Distant;Event;Focused Ultrasound;Focused Ultrasound Therapy;Foundations;Future;Heating;Immune;Immune checkpoint inhibitor;Immune response;Immune system;immunogenic;immunogenic cell death;immunogenicity;Immunologic Stimulation;Immunology;Immunosuppression;Immunotherapeutic agent;Immunotherapy;Infiltration;Inflammation;Inflammatory;inhibitor;insight;Intervention;Investigation;Ionizing radiation;Length;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Mechanics;Mediating;Melanoma;Metabolic;millimeter;Modality;mouse model;multidisciplinary;neoplastic cell;new technology;Pathway interactions;Patients;Physiologic pulse;pre-clinical;preservation;Process;Radiation;Role;Series;Signal Transduction;Site;T cell infiltration;T-Cell Depletion;Technology;Testing;Therapeutic;Thermal Ablation Therapy;Tissues;traditional therapy;Translating;tumor;tumor ablation;Tumor Antigens;Ultrasonic wave;Work

PROJECT_TITLE: Harnessing the therapeutic potential of histotripsy focused ultrasound-induced immunogenic cancer cell death

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-J(03)M]


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PI_NAMEs: WINKFIELD, KAREN MARIE (contact)

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TITLE: Cancer Outreach Core


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: LA JOLLA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative Synthetic biology holds the promise of transforming the development of diagnostic and treatment strategies for various diseases. This project applies synthetic biology approaches to reprogram fate decisions toward progressive cellular deterioration, a key factor in many diseases, such as cancers, diabetes, and neurodegenerative diseases. Key insights obtained from this project will define foundations for chemical or gene- based strategies to treating diseases related to progressive cellular deterioration.

PI_NAMEs: HAO, NAN  (contact);HASTY, JEFF M;PILLUS, LORRAINE ;TSIMRING, LEV S

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Abscisic Acid;Affect;Behavior;Biological Process;Cell Death;Cell Fate Control;cell injury;Cell Reprogramming;Cells;Cellular Morphology;Cessation of life;Chemicals;Complex;Computer Models;Core Protein;Coupled;Custom;Data;Deacetylase;Decision Making;design;Deterioration;Diabetes Mellitus;diagnostic development;diagnostic strategy;Disease;Dose;Doxycycline;Engineering;Eukaryota;experimental study;Foundations;gene conservation;Gene Expression;gene interaction;Genes;Genetic Engineering;Genetic Recombination;Genetic Transcription;Growth;Heme;improved;insight;Life;Lysine;Malignant Neoplasms;Mammals;Mediating;Microfluidics;Microscopy;Mitochondria;Mitotic;Modeling;models and simulation;Molecular;Mothers;Neurodegenerative Disorders;Organism;Pattern;Periodicals;Phenotype;Physiological;Play;Population;predictive modeling;Process;programs;promoter;protein expression;Proteins;Regulation;Research;Resources;Ribosomal DNA;Role;Saccharomyces cerevisiae;Saccharomycetales;Structure;synthetic biology;Synthetic Genes;System;Testing;Time;tool;treatment strategy;Yeasts

PROJECT_TITLE: Reprogramming cell-fate decisions through predictive modeling and synthetic biology

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: T-cells are a type of white blood cell that are needed to fight infections and can be artificially programmed to destroy cancer cells in patients. The goal of this project is to define whether increasing the activity of the gene BCL11B will expedite recovery of T-cells after bone marrow transplantation and improve the ability of programmed T-cells to kill cancer cells. The potential benefit of the knowledge gained from this project is the development of new methods to improve the recovery of the immune system after bone marrow transplantation, and ways to more effectively program T-cells to fight cancer.

PI_NAMEs: PAREKH, CHINTAN  (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TITLE: BCL11B activation as an approach for enhancing the efficacy of immunotherapy

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Diabetes;Kidney Disease

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PI_NAMEs: ORTEGA, MICHAEL A. (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Ablation;Address;Apoptosis Promoter;Autophagocytosis;Cells;Centers of Research Excellence;Chronic;Chronic Kidney Failure;Complication;Diabetic Nephropathy;Disease Management;Disease Progression;effectiveness evaluation;End stage renal failure;Fibroblast Growth Factor Receptors;Fibroblasts;Fibrosis;Functional disorder;Glucose;Hyperglycemia;Hypertension;I-kappa B Proteins;Impairment;improved;Inflammation;Kidney;kidney cell;Kidney Diseases;Molecular;Mus;NF-kappa B;NFKB Signaling Pathway;Non-Insulin-Dependent Diabetes Mellitus;Pathologic;podocyte;prevent;Renal function;Signal Transduction;systemic inflammatory response;therapeutic candidate;TNF gene;Tubular formation

PROJECT_TITLE: Non-canonical NF-kB signaling in diabetic kidney disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-T (C2)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dental, Oral, and Craniofacial Disease;Depression;Emerging Infectious Diseases;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Neurosciences;Nutrition;Patient Safety;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

PI_NAMEs: JOSEPH, PAULE  (contact)

PROJECT_TERMS: 2019-nCoV;Address;Adult;Affect;Ageusia;Alcohol abuse;alcohol craving;alcohol use disorder;Alcohols;Altered Taste;analytical method;Anhedonia;Anosmia;anxiety symptoms;biobank;Biological;Biological Markers;Chemicals;Child;Clinical Protocols;cohort;Collaborations;Community Outreach;coping;cost effective;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;COVID-19 patient;COVID-19 risk;COVID-19 stress;Data;depressive symptoms;design;drinking;Dysgeusia;Eating Behavior;Education;Esthesia;ethnic minority;exosome;experience;Extramural Activities;Family;Financial Hardship;follow-up;Food;Friends;Genetic;Grouping;Health;Health Personnel;high risk;home test;Household;hyposmia;Immune response;Impairment;Income;Individual;Infection;Inflammation;Institutional Review Boards;Interruption;Intervention;Irritants;Loneliness;Long COVID;Manuscripts;Measures;men;Mental Health;Minority Groups;Modeling;multimodality;nasal obstruction;National Institute on Alcohol Abuse and Alcoholism;Natural History;Neurologic Symptoms;neuromechanism;Neurons;Olfactory dysfunction;Outcome;Paraosmias;Participant;Patient Self-Report;Patients;perceived stress;Perception;Persons;Phenotype;physical conditioning;Post-Acute Sequelae of SARS-CoV-2 Infection;post-COVID-19;Prevalence;psychologic;Psychophysics;Public Health;Publishing;Quality of life;racial minority;Recording of previous events;Regression Analysis;Reporting;Research;Research Personnel;research study;Resolution;response;Risk;Role;SARS coronavirus;SARS-CoV-2 infection;Screening procedure;Sensory;Serology;Smell Perception;social;Standardization;stressor;Sum;Surveys;symptomatic improvement;Symptoms;System;Taste Perception;Testing;Time;Variant;Vulnerable Populations;Woman;Work;Writing

PROJECT_TITLE: Chemosensation and COVID-19


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Mental Illness;Neurosciences;Racial and Ethnic Minority Health Research;Rural Health;Substance Misuse

ORG_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

PI_NAMEs: GOLDMAN, DAVID  (contact)

PROJECT_TERMS: 11p;Address;Age;Alaska Native;Alcohol abuse;alcohol consequences;alcohol risk;alcohol use disorder;Alcoholism;Alcohols;Alleles;American Indian community;American Indian Population;American Indian Tribe;American Indians;Antisocial Personality Disorder;Anxiety;Behavioral;Benign;binge drinker;binge drinking;biological adaptation to stress;Candidate Disease Gene;case control;Categories;Centromere;Characteristics;Child;Chromosomes;Clinical;Collaborations;Communities;comorbidity;Complex;Connecticut;Copy Number Polymorphism;Data;Data Linkages;Data Set;density;Development;Diagnosis;Disease;DNA sequencing;DRD2 gene;DRD4 gene;drinking;Electroencephalography;Elements;exome;exome sequencing;experience;Family;Female;follow-up;Frequencies;GABA Receptor;Galanin;gamma-Aminobutyric Acid;gene discovery;gene environment interaction;Genes;Genetic;genetic linkage;genetic linkage analysis;Genetic Variation;Genome Scan;genome wide association study;genome-wide;Genomics;Genotype;Haplotypes;heart rate variability;Heavy Drinking;Heterogeneity;Impulsivity;Indiana;Individual Differences;inter-individual variation;Intermediate Variables;Interview;Laboratories;Linkage Disequilibrium;Low Prevalence;male;Maps;Mediating;Meiosis;Mental disorders;Methaqualone;Morbidity - disease rate;mortality;Naltrexone;Native American population;Native Americans;Neuropsychology;Oklahoma;Pathology;Patients;Pattern;Pharmacogenetics;Phenotype;Population;Prevalence;psychiatric comorbidity;public database;rare variant;receptor;Receptor Gene;Reporting;Research Personnel;Rest;Risk;Robin bird;Role;Scanning;Schizophrenia;Sertraline;sexual trauma;Signal Transduction;SNP genotyping;social;Stress;Structure;Surveys;Symptoms;telomere;trait;Trauma;treatment response;Tribes;Universities;Variant;Violence;whole genome;Woman;Work

PROJECT_TITLE: Genetic influences on alcohol use disorder in Native Americans


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Complementary and Integrative Health;Dietary Supplements;Genetics;Kidney Disease;Neurosciences;Nutrition;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Substance Misuse

PI_NAMEs: KIM, HEE-YONG  (contact)

PROJECT_TERMS: Adhesions;Adult;Affect;Agrin;Albumins;Albuminuria;alcohol effect;AMPA Receptors;analog;Animals;Anti-Inflammatory Agents;Anxiety;anxiety reduction;anxiety-like behavior;arm;Behavior;behavior test;Binding;Biochemical;Biological;Biological Assay;Biological Process;Bioluminescence;blood-brain barrier function;Brain;Cell Membrane Structures;Cells;comparative;Cyclic AMP;cytokine;Development;disease model;Docosahexaenoic Acids;Energy Transfer;enteropeptidase;Epithelial Cells;Ethanol;Exhibits;exome sequencing;extracellular;Extravasation;Filtration;Foot Process;Frequencies;Functional disorder;G Protein-Coupled Receptor Signaling;G-Protein Signaling Pathway;G-Protein-Coupled Receptors;glomerular filtration;glomerular function;Goals;GTP-Binding Proteins;Hippocampus;Human;human induced pluripotent stem cells;Immunoprecipitation;Impairment;in vivo;induced pluripotent stem cell;Inflammation;Inflammatory;Inflammatory Response;Injections;Injury;Injury to Kidney;interdisciplinary approach;Interleukin-1 beta;Internal Ribosome Entry Site;Investigation;KDR gene;Kidney;Knock-in;Knock-in Mouse;Knockout Mice;Label;Learning;Ligands;lipid metabolism;Lipopolysaccharides;Mass Spectrum Analysis;Membrane;Memory;Metabolic;Metabolism;Modeling;Modernization;Modification;Molecular;Mouse Strains;Mus;Mutagenesis;mutant;Mutation;N-Methyl-D-Aspartate Receptors;Nervous System;neurite growth;neurodevelopment;neurogenesis;neuron development;neuronal survival;Neurons;neuroprotection;neurotransmission;NF-kappa B;novel;Nuclear Pore Complex;object recognition;Omega-3 Fatty Acids;Orphan;overexpression;Pathway Analysis;Peptides;Phenotype;Phosphorylation;Physiological;Play;podocyte;polyunsaturated fat;Polyunsaturated Fatty Acids;Process;Production;Protein Conformation;protein expression;protein protein interaction;Proteins;Proteinuria;Proteome;Radial;receptor;Receptor Activation;receptor function;Regulation;Renal function;Research;Resolution;Rodent Model;Role;Sampling;Schizophrenia;Signal Transduction;Site;sperm protein;Structure;Synapses;synaptogenesis;Techniques;Testing;Therapeutic;Time;Tissues;TNF gene;Transfection;Transmission Electron Microscopy;Tubular formation;urinary;Urine;Variant;Vascular Permeabilities;VEGFA gene;Western Blotting

PROJECT_TITLE: Alterations In Lipid Metabolism In The Nervous System By Ethanol


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Bioengineering;Networking and Information Technology R&D (NITRD);Neurosciences;Substance Misuse

PI_NAMEs: VOGEL, STEVEN S (contact)

PROJECT_TERMS: Affinity;Anisotropy;Binding;Biological;biological systems;Biology;Biophotonics;Biosensor;Brain;Ca(2+)-Calmodulin Dependent Protein Kinase;Calcium;calcium-dependent protein kinase;calmodulin-dependent protein kinase II;Cells;Circular Dichroism;Collaborations;Comparative Study;Complex;cost;Coupling;Cyclic AMP;Dendritic Spines;dimer;Energy Transfer;Environment;Evolution;Fiber;Fiber Optics;Fluorescence;Fluorescence Anisotropy;Fluorescence Resonance Energy Transfer;Glutamates;Holoenzymes;Homo;Image;in vivo;instrumentation;interest;Internet;Kinetics;Laboratories;Ligand Binding;Ligands;Measurement;Measures;Methodology;Methods;Michigan;Microscopy;Molecular Conformation;Monitor;multimodality;Mus;Mutagenesis;National Institute of Child Health and Human Development;Organism;Phosphotransferases;Photometry;Photons;Physiological;protein protein interaction;Proteins;quantum;quantum computer;Quantum Mechanics;Site;Spectrum Analysis;Speed;Structure;Synapses;Temperature;Time;time use;Universities

PROJECT_TITLE: FRET and Excitonic imaging of protein-protein interactions inside living cells


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Sleep Research;Stimulant Use and Misuse;Substance Misuse

PI_NAMEs: VOLKOW, NORA D. (contact)

PROJECT_TERMS: actigraphy;Acute;addiction;Address;Adult;Affect;Affinity;aged;Alcohol dependence;alcohol exposure;Alcohols;Anesthesia procedures;Appearance;Attention;Attention deficit hyperactivity disorder;barrier to care;Behavior;behavior test;Behavioral;Binding;Brain;Buprenorphine;Carbon;carfentanil;Cerebrovascular Circulation;Chronic;Circadian Rhythms;Clinical Research;Cognitive;cognitive performance;Collaborations;Corpus striatum structure;Cross-Over Studies;Cyclic AMP;Data;Data Analytics;Development;Dopamine;Dopamine D1 Receptor;Dopamine D2 Receptor;dopamine system;Dorsal;Dose;Down-Regulation;Drug Addiction;drug reward;Drug usage;Eligibility Determination;Enrollment;Exhibits;experience;Female;Functional Magnetic Resonance Imaging;Goals;Heart Rate;heroin use;Hour;Human;Impairment;improved;Individual;Intervention;Investigation;Label;Lead;Light;light effects;Maintenance;Measures;medication for opioid use disorder;Methadone;Methods;MRI Scans;mu opioid receptors;multimodal neuroimaging;National Institute of Drug Abuse;National Institute of Mental Health;National Institute on Alcohol Abuse and Alcoholism;Neurobiology;neuropathology;opioid use disorder;Oral;Participant;Patients;PDE4B;Performance;Pharmaceutical Preparations;pharmacologic;Physiological;Placebo Control;Placebos;Play;Population;Positron-Emission Tomography;pre-clinical;Process;Protocols documentation;Proxy;radioligand;radiotracer;Rattus;receptor;Recording of previous events;Recovery;recruit;Reporting;Reproducibility;Research;response;Rest;Ritalin;Role;Scanning;screening;Signal Transduction;Single-Blind Study;Sleep;Sleep disturbances;Stimulant;Structure;Telephone;Testing;Thalamic structure;Time;tool;Tracer;trend;Up-Regulation;uptake;vapor;Ventral Striatum;Visual

PROJECT_TITLE: Neurobiology of Drug Reward and Addiction


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

PI_NAMEs: WINGFIELD, PAUL T (contact)

PROJECT_TERMS: Adopted;Anti-viral Agents;Antibodies;Archaea;Attention;Bacteria;Binding;Binding Sites;Biomedical Research;Capsid;carboxylate;Cells;Ceruloplasmin;Cessation of life;Clinical;Coupled;Cryoelectron Microscopy;design;diagnosis design;dimer;Drug Delivery Systems;Drug Targeting;Engineering;Environment;Ferritin;Geometry;Goals;Hepatitis B;Hepatitis B Therapy;Hepatitis B Virus;HIV;HIV-1;Human;human pathogen;In Vitro;interest;Intervention;Legal patent;Ligands;Liver diseases;macromolecular assembly;Macromolecular Complexes;Molecular;Molecular Conformation;Myxococcus xanthus;nano;Nature;Oxidative Stress;Peptides;Play;polypeptide;Population;promoter;Proteins;Reaction;Recombinants;Reporting;Research;Retroviridae;structural biology;System;Techniques;Vaccines;Viral;Virus;Virus Assembly;Virus Diseases;X-Ray Crystallography

PROJECT_TITLE: Structural Biology Of Virus Assembly


NIH_SPENDING_CATS: Aging;Arthritis;Autoimmune Disease;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Digestive Diseases;Eczema / Atopic Dermatitis;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Inflammatory Bowel Disease;Lupus;Orphan Drug;Pediatric;Primary Immunodeficiencies;Psoriasis;Rare Diseases;Rheumatoid Arthritis

ORG_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

PI_NAMEs: O'SHEA, JOHN  (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;Allergic;Alopecia Areata;Ankylosing spondylitis;antagonist;Arthritis;Atherosclerosis;Atopic Dermatitis;Autoimmune Diseases;autoimmune pathogenesis;Bacteria;Binding;cancer therapy;Cardiometabolic Disease;Cell Differentiation process;cell growth;cell type;Chronic Childhood Arthritis;clinical center;Clinical Trials;Collaborations;congenital immunodeficiency;Cooperative Research and Development Agreement;COVID-19;Crohn's disease;cytokine;cytokine release syndrome;Cytokine Signaling;Dermatomyositis;Development;Disease;Drug Utilization;Family;fungus;gain of function;Generations;Goals;graft vs host disease;Growth and Development function;Hematopoiesis;Host Defense;Human;IL7 gene;Immune;immune checkpoint blockade;immune modulating agents;Immune response;Immune System Diseases;Immunologic Deficiency Syndromes;improved;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;inhibitor;insight;Interleukin 2 Receptor Gamma;Interleukin-15;Interleukin-2;interleukin-21;Interleukin-4;Interleukin-9;Janus kinase;Laboratories;Legal patent;Lupus;Lymphoid;Mediating;Metabolism;Modeling;Molecular;Mus;Mutation;Myeloproliferative disease;Myositis;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;new therapeutic target;Pathogenesis;Patients;Phosphotransferases;Pre-Clinical Model;Protein Secretion;Psoriasis;Psoriatic Arthritis;Receptor Activation;response;Rheumatoid Arthritis;risk variant;Series;Severe Combined Immunodeficiency;skin disorder;Spondylarthritis;STAT1 gene;STAT4 gene;STAT6 gene;Systemic Lupus Erythematosus;Testing;tissue repair;Tissues;Ulcerative Colitis;Variant;Viral;Virus;Virus Diseases;Vitiligo

PROJECT_TITLE: Targeting Janus kinases in the treatment of autoimmune disease


NIH_SPENDING_CATS: Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;HIV/AIDS;Infectious Diseases

PROJECT_TERMS: 2019-nCoV;3-Dimensional;Acquired Immunodeficiency Syndrome;Active Sites;Adenosine;Affinity;Alanine;Amino Acids;Aneuploidy;Antibodies;antibody libraries;Antineoplastic Agents;aptamer;Bacteria;Binding;Binding Proteins;Binding Sites;Biological;Biosynthetic Proteins;C-terminal;Cell Nucleus;Cells;chimeric antibody;Chromatids;Communities;Complex;conformer;Cryoelectron Microscopy;Cryptophycin;Crystallization;Cyclic Peptides;cytotoxicity;design;Dexamethasone;dimer;DNA;Drug Design;Electron Microscopy;Exhibits;flexibility;Genetic Transcription;Genome;Glycoside Hydrolases;Hela Cells;HIV;HIV-1;HIV-1 integrase;Human;Immunoglobulin Fragments;improved;In Vitro;Indomethacin;insight;interest;Label;Life Cycle Stages;Malignant Neoplasms;Maps;Melons;Methodological Studies;Methods;Microscopy;Modeling;Molecular;Molecular Conformation;Molecular Structure;Molecular Weight;Momordica charantia;Multidimensional NMR Techniques;Mutation;Nature;Nuclear Magnetic Resonance;Oryctolagus cuniculus;particle;Penetration;Peptides;Phage Display;Preparation;prevent;Process;Production;protein structure;Protein Synthesis Inhibition;Proteins;Publications;Publishing;Recombinant DNA;Research;Resolution;Response Elements;rev Protein;RNA;RNA Conformation;RNA Folding;RNA Sequences;Role;SARS-CoV-2 inhibitor;Shapes;stable isotope;Structure;synergism;System;targeted treatment;Techniques;Therapeutic Intervention;three dimensional structure;Translating;Tubulin;tumor;Tyrosine;Viral;viral DNA;viral RNA;Virus;Virus Inactivation;Virus Replication;Work;X ray diffraction analysis;X-Ray Crystallography

PROJECT_TITLE: Production Of HIV And HIV Related Proteins For Structural Studies


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

PROJECT_TERMS: analytical ultracentrifugation;Antibodies;Binding;CD4 Antigens;Cell membrane;Cell surface;Cells;chemokine;Complex;Cryoelectron Microscopy;Crystallization;Detergents;Dissociation;Drug Screening;Drug Targeting;Engineering;Epitopes;Equilibrium;Fluorescence;Fluorescence Resonance Energy Transfer;Glycoproteins;gp160;high throughput screening;HIV;HIV Envelope Protein gp120;HIV Infections;improved;inhibitor;Libraries;Mediating;Membrane;Membrane Fusion;Membrane Glycoproteins;Membrane Potentials;Micelles;Modeling;Molecular;Molecular Conformation;monomer;Movement;Play;Process;receptor;Resolution;Role;sedimentation equilibrium;SIV;Solubility;Spectrum Analysis;Structure;System;Transmembrane Domain;Viral;Work

PROJECT_TITLE: Structure/Function of HIV/SIV Envelope Transmembrane Glycoprotein Gp41


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Eczema / Atopic Dermatitis;Emerging Infectious Diseases;Food Allergies;Genetics;Immunotherapy;Infectious Diseases;Rare Diseases

PROJECT_TERMS: 2019-nCoV;3-Dimensional;adaptive immune response;Affect;Allergens;Allergic;Allergic Disease;Allergic inflammation;amino acid metabolism;Anaphylaxis;Architecture;Asthma;Atopic Dermatitis;Autoimmune;Autoimmune Diseases;autoimmune pathogenesis;Autoimmunity;autosome;Bacteria;Biochemical Pathway;Boundary Elements;Bromodomain;CD4 Positive T Lymphocytes;Cell Differentiation process;Cells;Central Nervous System;Chromatin;Chromatin Loop;cohesin;Collagen;Complex;cytokine;cytokine release syndrome;Cytokine Signaling;cytopenia;Cytoprotection;Development;Disabling;Disease;DNA-Binding Proteins;EGR2 gene;Enhancers;Epigenetic Process;epigenomics;Exhibits;Family;Fibroblasts;Fibrosis;Food Hypersensitivity;FRAP1 gene;Frequencies;Functional disorder;fungus;gain of function;gain of function mutation;Gastrointestinal Diseases;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic Transcription;genetic variant;Genome;Goals;Growth and Development function;Helper-Inducer T-Lymphocyte;Hematopoiesis;Hematopoietic;Heterozygote;Hi-C;Homeostasis;Host Defense;Human;human disease;Hypersensitivity;hypogammaglobulinemia;IgE;IL3 Gene;Immune;immune function;Immune response;Immunity;immunodeficiency;immunopathology;immunoregulation;Impaired wound healing;improved;In Situ;In Vitro;in vivo;Infection;infectious disease model;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;Inheritance Patterns;Innate Immune Response;insight;Interferon Type II;Interleukin-10;Interleukin-13;interleukin-22;Interleukin-6;Investigation;Janus kinase;Knockout Mice;Lead;Link;loss of function;loss of function mutation;Lymphocyte;Lymphocytic choriomeningitis virus;Lymphoid;mathematical model;Mediating;Mediator;Metabolic;Metabolism;Modification;Molecular;Morphea;mortality;multiple sclerosis patient;Mus;Mutation;Myelin;Myeloid Cells;Natural Killer Cells;neuroinflammation;new therapeutic target;Parasitic infection;pathogen;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Peptidoglycan;Peripheral;Phenotype;phosphatidylinositol 3-kinase gamma;Phosphorylation;Phosphotransferases;Play;Population;Predisposition;Process;Production;progenitor;programs;promoter;Proprotein Convertases;Protein Secretion;Proteins;Proto-Oncogene Proteins c-akt;Psoriasis;rare variant;recruit;Regulation;Regulatory Element;response;restraint;Rheumatoid Arthritis;Role;Scleroderma;sensor;Signal Transduction;Skin;Squamous cell carcinoma;STAT protein;STAT1 gene;STAT4 gene;Stat5 protein;STAT6 Transcription Factor;Subtilisins;Systemic Lupus Erythematosus;T cell differentiation;T-Lymphocyte;Th1 Cells;Therapeutic;tissue repair;Tissues;Toxoplasmosis;transcription factor;transcriptome;Transforming Growth Factor beta;Variant;Viral;Viral Load result;Virus;Virus Diseases;Work;wound healing

PROJECT_TITLE: Cytokine Signaling, Immunoregulation and Autoimmune and Immunodeficiency Diseases


NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Pediatric;Rare Diseases

PI_NAMEs: MORASSO, MARIA  (contact)

PROJECT_TERMS: Abscess;Adult;Amelogenesis;Amino Acids;appendage;autosomal dominant mutation;Child;cohort;Defect;Dental caries;Dental Caries Susceptibility;Dental Enamel;Dentin;Development;Ectodermal Dysplasia;Epithelium;Genes;Genetic Polymorphism;Genetic Transcription;Hair;Hair Diseases;Hardness;Homeodomain Proteins;Infection;Keratin;keratinocyte;Knock-in Mouse;Linear Regressions;Loose anagen hair syndrome;mineralization;Mutation;Pathway interactions;Play;Predisposition;Process;Proteins;Regression Analysis;Regulation;Research;Rod;Role;Study models;Tooth structure

PROJECT_TITLE: Ectodermal Dysplasias and Regulation of Ectodermal Appendage Development


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Back Pain;Clinical Research;Pain Research;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: COLBERT, ROBERT  (contact)

PROJECT_TERMS: Acceleration;Adolescent;Adult;Affect;Animal Model;Ankylosing spondylitis;Ankylosis;Back Pain;Bone Marrow;Cells;Child;Childhood;Chronic;Chronic Childhood Arthritis;Classification;Clinical;Colonic inflammation;cytokine;de novo mutation;Diagnosis;Disease;disease phenotype;early onset;Early treatment;Edema;Enthesitis-Related Arthritis;Exhibits;exome;Genetic;genetic variant;genome sequencing;Goals;HLA-B Antigens;IL17 gene;Image;improved;Inflammation;Inflammatory;Institution;interleukin-23;joint inflammation;Joints;Laboratories;Lesion;Link;Magnetic Resonance Imaging;Mediating;Mesenchymal;mineralization;Modeling;Morbidity - disease rate;Onset of illness;Osteoblasts;Osteogenesis;osteogenic;Osteomyelitis;Outcome;overexpression;Participant;Pathogenesis;Pathogenicity;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Physicians;Population;Production;Proteins;Rattus;Reporting;research study;response;Role;Sacroiliac joint structure;Specificity;Spondylarthritis;stem cell differentiation;Susceptibility Gene;Symptoms;System;T-Lymphocyte;targeted treatment;transcription factor CHOP;Variant;Vertebral column;Work;Youth

PROJECT_TITLE: Pathogenic Mechanisms in Spondyloarthritis


NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Clinical Research;Precision Medicine;Rare Diseases

PI_NAMEs: GRAYSON, PETER  (contact)

PROJECT_TERMS: Adult;aged;ANCA vasculitis;Aortitis;Area;Arteries;Autoimmune Diseases;autoinflammatory;biobank;Biological Markers;Biological Specimen Banks;biomarker development;biomarker discovery;Blood Vessels;Bone Marrow;Bone Marrow Transplantation;cartilaginous;chest computed tomography;Chronic Disease;Classification;Clinical;Clinical assessments;clinical care;clinical center;clinical heterogeneity;clinical outcome measures;clinical remission;Clinical Research;Clinical Trials;Clinical Trials Database;cohort;Collaborations;Communication;Complex;COVID-19 impact;Data;Data Collection;data standards;Dedications;design;Development;Diagnosis;diagnostic algorithm;Diagnostic tests;disability;Disease;disease heterogeneity;Disease Management;disease natural history;Disease Progression;Ear;Enzymes;epidemiology study;Ethics;Etiology;Evaluation;Extramural Activities;fluorodeoxyglucose positron emission tomography;Foundations;Future;Genetic;genetic variant;Germ-Line Mutation;Goals;Health behavior;Hearing Tests;Hematology;Image;imaging biomarker;Immune response;Immunologics;indexing;Inflammation;inflammatory marker;Intramural Research;Joints;Laboratories;Laryngoscopy;Lead;Lesion;Life;Light;Link;Magnetic Resonance Imaging;Methods;Molecular;molecular imaging;Monitor;Morbidity - disease rate;mortality;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Natural History;Neck;next generation sequencing;North America;Nose;novel;novel marker;observational cohort study;Organ;Oscillometry;Outcome;pandemic disease;pandemic impact;Pathogenesis;patient advocacy group;patient oriented;Patient Selection;patient subsets;Patients;Pattern;personalized medicine;Physical Examination;Physicians;Positron-Emission Tomography;predict clinical outcome;Prediction of Response to Therapy;Prognostic Factor;programs;prospective;Protocols documentation;Publishing;Pulmonary function tests;radiological imaging;Radiology Specialty;randomized, clinical trials;Recording of previous events;recruit;Relapse;Relapsing polychondritis;Reporting;Research;research clinical testing;Research Design;Research Personnel;Rheumatism;Role;Sampling;SARS-CoV-2 exposure;Shapes;Somatic Mutation;Source;standard of care;Steroids;Structure;Surveys;Syndrome;System;Systemic disease;Takayasu's Arteritis;Temporal Arteritis;therapeutic evaluation;Time;Tissues;Tracheostomy procedure;translational medicine;Translational Research;translational research program;Treatment Efficacy;trial design;United States National Institutes of Health;Vacuole;vascular inflammation;Vasculitis;Work

PROJECT_TITLE: Vasculitis and Translational Medicine


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Racial and Ethnic Minority Health Research;Scleroderma

PI_NAMEs: GOURH, PRAVITT  (contact)

PROJECT_TERMS: 2019-nCoV;admixture mapping;Affect;African;African American;African American population;African ancestry;Alleles;American;Amino Acids;angiogenesis;Antigen Presentation;Antigens;Antinuclear Antibodies;Autoantibodies;Autoantigens;Autoimmunity;Biological Markers;Blood Vessels;burden of illness;Calcinosis;Calcium;Chronic;Clinical;clinical phenotype;Code;cohort;Collaborations;Collection;Complication;conditioning;Cutaneous;cytokine;Cytokine Signaling;Data;Deposition;Dermis;Development;Dideoxy Chain Termination DNA Sequencing;Diffuse;Disease;disorder risk;DNA;Endothelium;Enrollment;epithelial to mesenchymal transition;European;exome;exome sequencing;Exons;Family;FDA approved;Fibrosis;Frequencies;GDF9 gene;Gene Expression Regulation;Gene Proteins;Genes;Genetic;genetic risk factor;Genetic study;genetic testing;Genome;genome wide association study;genome-wide;Genotype;Goals;health disparity;High Prevalence;HLA Antigens;HLA-DPB1 gene;Inflammation;Inflammatory;inhibitor therapy;inorganic phosphate;insight;Interleukin-1;interleukin-1 receptor accessory protein;Interleukin-1 Receptors;Interleukin-13;Ligands;loss of function;Lung;Mediating;Mesenchymal;Metabolism;MicroRNAs;Molecular;Molecular Mimicry;Morbidity - disease rate;mortality;mouse model;multi-ethnic;National Human Genome Research Institute;NOTCH4 gene;novel;Organ;overexpression;Pathogenesis;Pathway interactions;Patients;Phase;Play;Population;Predisposition;protective effect;Proteins;Quality Control;Quality of life;rare variant;receptor;Regression Analysis;Reporting;Research;Rheumatism;Risk;Risk Factors;risk variant;Role;Sampling;Scleroderma;Sequence Analysis;Signal Transduction;Single Nucleotide Polymorphism;Skin;skin fibrosis;Subcutaneous Tissue;Susceptibility Gene;System;Systemic Scleroderma;T cell receptor repertoire sequencing;T-cell receptor repertoire;targeted treatment;Technology;Testing;TGFB3 gene;Time;Transcriptional Regulation;Underserved Population;United States National Institutes of Health;Untranslated Regions;Variant;Vascular Diseases;Work

PROJECT_TITLE: Genetics and Pathogenesis of Scleroderma


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Eye Disease and Disorders of Vision;Immunization;Infectious Diseases;Prevention;Rheumatoid Arthritis;Scleroderma;Vaccine Related

PI_NAMEs: KAPLAN, MARIANA  (contact)

PROJECT_TERMS: ANCA vasculitis;Autoantibodies;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;Blood Vessels;Chronic;Clinical;COVID-19;COVID-19 vaccine;Diagnosis;Exposure to;Idiopathic Inflammatory Myopathies;Immune;immunoregulation;Individual;Infection;Inflammation;Inflammatory Response;Kidney Diseases;Mediating;multiple omics;pandemic disease;participant enrollment;Patients;Phenotype;response;Rheumatoid Arthritis;SARS-CoV-2 exposure;SARS-CoV-2 infection;Scleroderma;Sjogren's Syndrome;Statistical Data Interpretation;systemic autoimmunity;Systemic Lupus Erythematosus;Vaccination;Vaccines;Visit

PROJECT_TITLE: Modulation of chronic inflammatory responses by COVID19


PI_NAMEs: FRANCO, LUIS  (contact)

PROJECT_TERMS: Affect;Anti-Inflammatory Agents;Cell Line;cell type;Cells;Clinical;clinical effect;Collaborations;Data;Development;Disease;drug action;drug discovery;Drug Prescriptions;experimental study;Extramural Activities;Flow Cytometry;follow-up;functional genomics;Gene Expression;Genetic Transcription;Genomic approach;Genomics;Glucocorticoids;Goals;healthy volunteer;high throughput screening;Homeostasis;Human;Immune;Immune system;Immunosuppression;In Vitro;in vivo;Individual;Kinetics;Knowledge;Laboratories;Macaca fascicularis;Macaca mulatta;Medicine;Methodology;Methods;Methylprednisolone;migration;Molecular;nanobodies;National Institute of Allergy and Infectious Disease;neutrophil;Pattern;peripheral blood;PET/CT scan;Pharmaceutical Preparations;Physiological;Population;programs;Publishing;Repression;Research;response;RNA;Sampling;Series;side effect;Signal Pathway;single molecule;System;Technology;Testing;Tissues;transcriptome sequencing;Translational Research;Translations;United States National Institutes of Health;Work;X-Ray Computed Tomography

PROJECT_TITLE: Integrative genomic analysis of the human response to glucocorticoids


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Human Genome;Lupus;Pediatric

PI_NAMEs: LEWANDOWSKI, LAURA  (contact)

PROJECT_TERMS: Acceleration;Adult;Affect;Age;age group;Autoimmune Diseases;Bioinformatics;Biological;Biological Process;causal variant;Childhood;Clinical;clinical phenotype;cohort;Collaborations;Complex;Country;Data;Data Analyses;Data Set;Disease;DNA Repair Gene;early onset;Equilibrium;European ancestry;Event;exome sequencing;Family;Foundations;Functional disorder;Gene Cluster;Gene Expression;Genes;Genetic;genetic analysis;genetic architecture;genetic association;Genetic Risk;Genetic Structures;Genetic study;genetic variant;Genome;genome sequencing;genome wide association study;genome-wide;genomic data;Goals;health disparity;Heritability;human disease;Individual;insight;Interferons;International;Investigation;Life;Link;Lupus;Methodology;Molecular Diagnosis;molecular phenotype;Movement;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Natural History;Nephritis;next generation sequencing;novel;Onset of illness;Parents;participant enrollment;Pathogenesis;Pathway Analysis;Pathway interactions;Patient Selection;patient stratification;Patients;Phenotype;polygenic risk score;Population;Population Heterogeneity;Predisposition;Process;protein function;Proteins;Protocols documentation;rare variant;Reporting;Research;Research Personnel;Risk;risk variant;RNA Processing;Role;Sampling;Severity of illness;Siblings;Single Nucleotide Polymorphism;Site;Susceptibility Gene;System;Systemic Lupus Erythematosus;targeted treatment;Testing;tool;transmission process;Twin Multiple Birth;Validation;Variant;variant of interest;whole genome

PROJECT_TITLE: Genetics and pathophysiology of systemic lupus erythematosus in global populations


NIH_SPENDING_CATS: Cancer;Clinical Research;Eczema / Atopic Dermatitis;Infectious Diseases;Primary Immunodeficiencies;Rare Diseases

PI_NAMEs: KONG, HEIDI  (contact)

PROJECT_TERMS: Adverse reactions;Alopecia;Autoimmune Diseases;Bacterial Infections;Chronic;clinical center;Collaborations;Communities;congenital immunodeficiency;Cutaneous;Disease;DOCK8 deficiency;Doxycycline;Drug Hypersensitivity;Eczema;Evaluation;GATA2 deficiency;Goals;Hematopoietic Stem Cell Transplantation;Hereditary Disease;Hereditary Leiomyomatosis and Renal Cell Cancer;Hereditary Malignant Neoplasm;Immune system;improved;Individual;Infection;Inflammatory;Ingestion;insight;interest;Intervention;Intramural Research Program;Investigation;Investigational Therapies;Lesion;Malignant Neoplasms;Methods;microbiome;Mycoses;Natural History;Omenn syndrome;Oncology;Pathogenesis;patient population;Patients;Phototoxicity;Polyglandular Autoimmune Syndrome Type I;Research;Research Personnel;Skin;skin disorder;skin lesion;Syndrome;targeted treatment;Therapeutic Intervention;Toxic effect;United States National Institutes of Health;Viral;WHIM syndrome;Work

PROJECT_TITLE: Investigation of the natural history and pathogenesis of skin diseases


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Eczema / Atopic Dermatitis;Genetics;Human Genome;Infectious Diseases;Microbiome;Pediatric;Primary Immunodeficiencies;Rare Diseases

PROJECT_TERMS: Adult;Affect;Atopic Dermatitis;Autoimmune Diseases;autosome;Bacteria;Child;Collaborations;Communities;congenital immunodeficiency;Disease;DOCK8 deficiency;fungus;Genome;genome sequencing;Genomic approach;Goals;Health;Human;Human body;Human Microbiome;human microbiota;Human Papillomavirus;Hyper-IgE Syndrome;Immunologic Deficiency Syndromes;improved;Individual;Infectious Skin Diseases;Inflammatory;interest;Intervention;Malignant Neoplasms;Merkel Cells;metagenomic sequencing;Microbe;microbial;microbial community;microbiota;Nursing Homes;Omenn syndrome;Patients;Phase;Polyglandular Autoimmune Syndrome Type I;Polyomavirus;Population;Publishing;Research Personnel;Role;Shotguns;Skin;skin disorder;skin microbiome;Technology;United States National Institutes of Health;Virus;WHIM syndrome;whole genome

PROJECT_TITLE: Studies of human microbes and potential perturbations


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Microbiome

PROJECT_TERMS: antiretroviral therapy;Clinical;Collaborations;comorbidity;Complex;Data;Disease;Goals;HIV;HIV Infections;host microbiota;Human Microbiome;Immune system;Immune System Diseases;Immunity;Individual;Inflammation;Inflammatory;microbial;microbiome;microbiome sequencing;Monitor;Opportunistic Infections;Persons;Predisposition;Research Proposals;Skin;Viral Load result

PROJECT_TITLE: Investigating the microbiome in persons living with HIV


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: BROWNELL, ISAAC  (contact)

PROJECT_TERMS: Afferent Neurons;ATAC-seq;Blood Vessels;cell behavior;Cell Differentiation process;Cell Lineage;Development;differentiation in vitro;Embryo;Environment;experimental study;Genetic Transcription;Hair follicle structure;interest;intraepithelial;Maintenance;Merkel cell carcinoma;Merkel Cells;Modeling;mouse genetics;Mus;Neurosecretory Systems;novel;perineural;Process;Regulation;Sensory;Signal Transduction;single-cell RNA sequencing;Skin;stem cell population;stem cells;Touch sensation;Work

PROJECT_TITLE: Development and regulation of stem cell lineages in skin


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Rare Diseases;Skin Cancer

PROJECT_TERMS: Animal Model;Biological Markers;Cancer cell line;Cancer Etiology;Cell Culture Techniques;Cell Line;Cell Therapy;cell transformation;Cells;Characteristics;Chromosome abnormality;Chronic Lymphocytic Leukemia;clinical biomarkers;Clinical Protocols;Data;data registry;Development;Diagnosis;Diagnostic;Disease;Disease Progression;Epigenetic Process;Gene Expression Profiling;Gene Mutation;Genetic;genetic manipulation;genetic risk factor;genome-wide;Goals;High-Risk Cancer;HIV Infections;Human;Human Cell Line;Immune response;Immune system;immunogenic;In Vitro;in vivo;Infection;innovation;knock-down;Maintenance;Malignant - descriptor;Malignant Epithelial Cell;Malignant Neoplasms;Merkel cell carcinoma;Merkel Cells;Modification;Molecular;Molecular Analysis;mouse model;Mus;Mutation;neoplasm registry;Neuroendocrine Cell;novel;Oncogenic;Outcome;Pathogenesis;Pathway interactions;Patients;Polyomavirus;Polyomavirus Transforming Antigens;Population;pre-clinical;preclinical development;prevent;prognostic;response;Risk;Risk Factors;Sampling;Skin;Skin Cancer;small molecule;T-Lymphocyte;Testing;therapeutic target;tumor;Tumor Cell Line;Virus;Work;Xenograft procedure

PROJECT_TITLE: Molecular pathogenesis and therapy innovation for Merkel cell carcinoma


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Orphan Drug;Rare Diseases;Skin Cancer

PROJECT_TERMS: Adjuvant Therapy;Alternative Therapies;anti-PD-L1 antibodies;anti-tumor immune response;Biological Assay;Biological Markers;Blood;cancer immunotherapy;cancer therapy;Chronic Lymphocytic Leukemia;Clinical Research;Clinical Treatment;Clinical Trials;Clinical Trials Design;Diagnosis;Disease;Enrollment;Goals;HIV Infections;Immune response;Immune system;Immunotherapy;improved;Institution;interest;Malignant - descriptor;Merkel cell carcinoma;microbiome;Neuroendocrine Cell;open label;Operative Surgical Procedures;Participant;participant enrollment;Patients;Pharmaceutical Preparations;phase 2 study;Protocols documentation;Radiation;Rare Diseases;response;Risk Factors;Sampling;Seminal;Site;Skin;small molecule;Specimen;Testing;therapy resistant;tumor;United States National Institutes of Health

PROJECT_TITLE: Clinical treatment of advanced Merkel cell carcinoma


PROJECT_TERMS: Adverse event;Antineoplastic Agents;Cancer Center;cancer immunotherapy;cancer therapy;Chimeric Proteins;Clinical;clinical center;Clinical Management;Collaborations;Complex;Cutaneous;Diagnosis;diagnostic biomarker;Functional disorder;Health;Health Sciences;immune-related adverse events;Immunooncology;Immunosuppression;Inflammatory;interest;Investigation;Malignant Neoplasms;Medical center;melanoma biomarkers;Military Personnel;novel;novel therapeutic intervention;oncology program;Organ;Pathology;Patients;predictive marker;prevent;Prognostic Marker;proteogenomics;Research Personnel;Running;Sebaceous Adenocarcinoma;Skin;Skin Cancer;Skin Carcinoma;skin disorder;Skin Neoplasms;United States National Institutes of Health;University Health Services

PROJECT_TITLE: Investigation of skin cancer and skin disease


NIH_SPENDING_CATS: Cancer;Eczema / Atopic Dermatitis;Infectious Diseases;Microbiome;Primary Immunodeficiencies;Rare Diseases

PI_NAMEs: NAGAO, KEISUKE  (contact)

PROJECT_TERMS: Allergens;Alopecia;Atopic Dermatitis;Bacterial Infections;Bilateral;Biology;cell type;Cells;chemokine;Clinical;clinically relevant;commensal bacteria;Communication;Communities;Complex;congenital immunodeficiency;Corynebacterium;Cutaneous;cytokine;Degos disease;Disease;Drug Hypersensitivity;dysbiosis;Eczema;Ensure;Epidermal Growth Factor Receptor;Epidermis;Epithelium;Exhibits;Exposure to;Extracellular Matrix;Fibroblasts;Foundations;Functional disorder;Hair follicle structure;Homeostasis;host-microbe interactions;Human;Hyaluronic Acid;Immune;Immune system;Immunity;immunological status;Immunologics;Impairment;Inflammation;Inflammatory;Insulin-Like Growth Factor I;Interferon Type I;Invaded;Investments;keratinocyte;Knowledge;Laboratories;Langerhans cell;Leukocytes;Lymphoid Cell;Macrophage;Malignant - descriptor;Mechanical Stress;Mediating;Metalloproteases;Microbe;microbial;microbial host;microbiome;Modeling;mouse model;Mus;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Neurons;notch protein;novel;Organ;Pathologic;Pathway interactions;Poly I-C;Population;Predisposition;pressure;Process;Protocols documentation;Psoriasis;Publishing;receptor;Receptor Signaling;recruit;repaired;Role;Sebaceous Glands;Signal Transduction;Site;Skin;skin disorder;skin microbiome;Sorting;Staphylococcus aureus;Staphylococcus aureus infection;stem cells;Stimulus;Structure;Subcutaneous Tissue;Sunlight;Surface;Symbiosis;T memory cell;Techniques;Tissues;Toxin;transcriptomics

PROJECT_TITLE: Exploring mechanisms that govern immune homeostasis in skin


PI_NAMEs: COWEN, EDWARD  (contact)

PROJECT_TERMS: Annual Reports;Bibliography;Biology;Book Chapters;CCR;Cell Therapy;chronic graft versus host disease;Clinical;clinical outcome assessment;Clinical Trials;Collaborations;Consensus;Cutaneous;Educational workshop;Extramural Activities;genetic signature;Immunologics;immunoreaction;Immunotherapy;innovation;International;Laboratories;multidisciplinary;novel;Outcome Measure;Paper;Patient Outcomes Assessments;Patients;Phenotype;Photography;Skin;skin biopsy;Specimen;Systemic disease;United States National Institutes of Health;Universities

PROJECT_TITLE: Chronic graft-versus-host disease


NIH_SPENDING_CATS: Cancer;Clinical Research;Patient Safety;Rare Diseases

PROJECT_TERMS: Annual Reports;Attention;Benign;cancer risk;Clinical;clinical care;Clinical Protocols;Collaborations;Consult;Consultations;Cutaneous;Dermatology;Disease;Event;Exposure to;Genotype;Histologic;Link;Medical Students;Nail plate;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;news;novel;Nurse Practitioners;Phenotype;Physician Assistants;Predisposition;Protocols documentation;Publications;rare condition;Reporting;research clinical testing;Services;Skin;skin disorder;Sweet's Syndrome;Syndrome;tumor;Visit

PROJECT_TITLE: Dermatology Consultation Service


NIH_SPENDING_CATS: Genetics;Human Genome;Infectious Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

PI_NAMEs: MORRISON, TASHA  (contact)

PROJECT_TERMS: Ablation;Antigens;Architecture;Binding;Bone Marrow;cancer cell;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Death Induction;Cell Maintenance;Cell membrane;cell motility;Cell Physiology;Cell surface;Cell Survival;Cells;Cellular biology;Cellular Structures;Ceramide glucosyltransferase;chemokine receptor;ChIP-seq;Chromatin;Classification;Code;Complex;CRISPR/Cas technology;cytokine;Cytokine Receptors;Cytomegalovirus Infections;Cytoplasmic Granules;cytotoxic;Data;Development;Drug usage;Enhancers;Enzymes;EP300 gene;epigenomics;Excision;Flow Cytometry;Frequencies;Gene Expression;Genes;Genetic Transcription;Genome;Genomics;Glycosphingolipids;glycosylation;Goals;Hematopoietic;Hematopoietic stem cells;High-Throughput Nucleotide Sequencing;Image;Immune;Immune response;Impairment;Infection;Infiltration;interest;Knockout Mice;Length;Link;lipidomics;Location;Lymphocyte;Lymphoid Cell;Lymphoid Tissue;Malignant Neoplasms;Membrane Microdomains;Memory;Microscopy;Mobility decline;Modeling;Molecular;mouse model;Murid herpesvirus 1;Mus;Myocardial Ischemia;Natural Killer Cells;novel;Pattern;Play;Process;progenitor;Proteins;Publishing;Repression;Research;response;RNA Polymerase II;Role;Secondary to;Signal Transduction;Site;Spleen;stem cells;symptomatic improvement;T-Lymphocyte;trafficking;Transcript;Transcription Coactivator;transcription factor;transcriptome sequencing;tumor;Untranslated RNA;Up-Regulation;Viral;Work

PROJECT_TITLE: Lymphocyte signaling and immune cell response


NIH_SPENDING_CATS: Biotechnology;Genetics

PI_NAMEs: CHISOLM, DANIELLE  (contact)

PROJECT_TERMS: asthma model;CD4 Positive T Lymphocytes;Cell Differentiation process;Cells;Chromatin;cytotoxic;Data;Data Set;Development;Environment;Exposure to;GATA3 gene;Gene Expression Regulation;Genes;Goals;Immune;In Vitro;Inflammatory;insight;Lymphocyte Subset;Modeling;Molecular;mouse model;muscle progenitor cell;next generation sequencing;novel;Nuclear;pathogen;peripheral lymphoid organ;Play;programs;Role;single cell sequencing;single cell technology;Specific qualifier value;T cell differentiation;T-Cell Development;T-Lymphocyte;Technology;Th2 Cells;Thymus Gland;transcription factor;Transcriptional Regulation

PROJECT_TITLE: Defining the role of Paxbp1 in T cell development and T helper specification


NIH_SPENDING_CATS: Clinical Research

PI_NAMEs: CASTELO-SOCCIO, LESLIE  (contact)

PROJECT_TITLE: Natural history, pathogenesis, and treatment of alopecia


NIH_SPENDING_CATS: Cancer;Climate-Related Exposures and Conditions;Clinical Research;Genetics;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Skin Cancer

ORG_NAME: DIVISION OF BASIC SCIENCES - NCI

PI_NAMEs: KRAEMER, KENNETH H (contact)

PROJECT_TERMS: 20 year old;Adult;Affect;Age;Alleles;Autopsy;Big Data;Blood specimen;BRAF gene;brain size;cancer prevention;cancer risk;Cataract;Cessation of life;Child;Clinical;Cockayne Syndrome;cohort;Collaborations;Data Analyses;Databases;Defect;Development;Disease;Disseminated Malignant Neoplasm;Division of Cancer Epidemiology and Genetics;DNA;DNA Repair;DNA Repair Gene;Doctor of Medicine;ERCC1 gene;ERCC3 gene;Eye Abnormalities;Family member;femur head;Fetal Development;Follow-Up Studies;Frequencies;Functional disorder;Gene Modified;gene repair;General Population;Genes;Genetic Diseases;Genetic Transcription;Goals;Gynecologic;Hair;Health;hearing impairment;Hematologic Neoplasms;Heterogeneity;Histologic;Human;Human Development;Hypersensitivity;Immune checkpoint inhibitor;infancy;Infant;insight;Investigation;Italy;Laboratories;Link;Longterm Follow-up;Malignant neoplasm of pancreas;Malignant Neoplasms;Melanoma;member;Messenger RNA;Methods;Molecular;Mothers;Mutation;Natural History;Necrosis;Nerve Degeneration;Nevi and Melanomas;Nucleotide Excision Repair;offspring;Operative Surgical Procedures;Patients;Peripheral Nervous System Diseases;Phenotype;Physicians;Point Mutation;Polymerase;Postoperative Complications;Predisposition;Pregnancy;Pregnancy Complications;Premature aging syndrome;Premature Menopause;Process;Protocols documentation;PTEN gene;Publishing;Rare Diseases;rare genetic disorder;Reporting;Research;response;Risk;RNA Splicing;Role;Series;side effect;Skin;Skin Cancer;Skin Carcinoma;Study Subject;Sun Exposure;Surveys;Thyroid Nodule;Translational Research;Trichothiodystrophy;Tumor Suppressor Genes;Ultraviolet Rays;United States National Institutes of Health;Variant;Walking;Woman;Xeroderma Pigmentosum;XPA gene

PROJECT_TITLE: DNA Repair in Human Cancer-Prone Genetic Diseases


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Rare Diseases

PI_NAMEs: HAGER, GORDON L (contact)

PROJECT_TERMS: 3-Dimensional;Architecture;Biological Models;Bromodomain;Bromodomains and extra-terminal domain inhibitor;cancer therapy;carcinogenesis;Cell Nucleus;ChIP-seq;Chromatin;Chromatin Loop;chromatin modification;Chromatin Structure;Chromosome Territory;cohesin;Complex;Disease;DNA;Elasticity;Enhancers;Environment;Epigenetic Process;Gene Activation;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic Transcription;Genome;genome-wide;Glucocorticoid Receptor;glucose metabolism;Growth;Heterogeneity;Human Genome;Impairment;In Vitro;in vivo;induced pluripotent stem cell;interest;knock-down;Ligands;Link;Lung;lung cancer cell;Malignant neoplasm of lung;Mediator;methylome;Modeling;Modification;Neurosecretory Systems;NFIC gene;novel;Nuclear;Nuclear Receptors;Pathway interactions;patient derived xenograft model;prevent;Process;promoter;Promoter Regions;Property;Protein Family;Proteins;Regulatory Element;Repression;Role;Site;small cell lung carcinoma;stemness;Structure;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;Work

PROJECT_TITLE: Chromatin Structure and Gene Expression


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: KIMURA, SHIOKO  (contact)

PROJECT_TERMS: Acute;Address;adenoma;Adult;adult stem cell;Age;Amitrole;Area;Azoles;Benign;Bone Marrow Cells;Bone Marrow Transplantation;cancer stem cell;carcinogenesis;Cartilage;cell growth;Cell Line;Cell surface;Cells;Characteristics;Development;Diet;differential expression;Differentiation Antigens;Digestion;E-Cadherin;Epithelium;Equilibrium;established cell line;experimental study;Gene Expression Profiling;Gene Mutation;Genes;Genetic Markers;genome sequencing;Genotype;Goals;Goitrogens;Growth;Growth Factor;Herbicides;homeodomain;Homeostasis;Human;Immune;Immunocompromised Host;Immunohistochemistry;In Situ Hybridization;inhibitor;Injury;Insulin-Like Growth Factor I;Insulin-Like-Growth Factor I Receptor;interest;Iodide Peroxidase;laser capture microdissection;Malignant neoplasm of thyroid;Malignant Neoplasms;Mesenchymal;Messenger RNA;Microbial Collagenase;Missense Mutation;Modeling;Mus;Muscle;Mutation;nano-string;Natural regeneration;Nature;Nodule;novel;Organ;overexpression;Pattern;Physiology;Play;Process;Proliferating;promoter;Quantitative Reverse Transcriptase PCR;receptor;RNA;Role;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;stem cells;Stromal Cell-Derived Factor 1;Structure;Subcutaneous Injections;Thinness;Thyroid Diseases;Thyroid Function Tests;Thyroid Gland;thyroid neoplasm;Thyroidectomy;Thyrotropin Receptor;Tissues;tool;Trachea;transcription factor;transcriptome sequencing;Transgenic Mice;tumor;Tumor Suppressor Genes;Vimentin;whole genome;Wild Type Mouse;Xenograft procedure

PROJECT_TITLE: Thyroid regeneration and carcinogenesis


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Digestive Diseases;Endocrine Disruptors;Health Effects of Indoor Air Pollution;Lung;Lung Cancer;Prevention;Tobacco;Tobacco Smoke and Health

PI_NAMEs: GONZALEZ, FRANK J (contact)

PROJECT_TERMS: Age;Area Under Curve;Asbestos;Biological Assay;Biological Markers;cancer biomarkers;carcinogenesis;Carcinogenesis Mechanism;Cessation of life;cohort;Collaborations;Colon Carcinoma;computed tomography screening;Creatine;Diagnosis;Disease;Eligibility Determination;Environmental Pollution;Etiology;Experimental Designs;Exposure to;fatty liver disease;Genitourinary system;Goals;high risk;Hospitals;Human;Insulin Resistance;Laboratories;liquid biopsy;liquid chromatography mass spectrometry;low dose computed tomography;lung cancer screening;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Metabolic Diseases;Metastatic Prostate Cancer;Mus;N-Acetylneuraminic Acid;non-smoker;Obesity;Participant;Passive Smoking;Performance;Population Control;programs;Prospective Studies;Radon;receptor;riboside;Risk Factors;ROC Curve;Role;Sampling;sex;Specimen;tobacco smokers;transcription factor;United States;urinary;Urine;Validation;Xenobiotics

PROJECT_TITLE: Xenobiotic receptors


NIH_SPENDING_CATS: Cancer;Genetics;Natural Products

PI_NAMEs: GOTTESMAN, MICHAEL  (contact)

PROJECT_TERMS: ABCB1 gene;ABCB6 gene;ABCC1 gene;ABCG2 gene;Anti-tumor Natural Products;ATP-Binding Cassette Transporters;Belgium;Binding;Biological Availability;Blood - brain barrier anatomy;Brain;cancer cell;cancer drug resistance;Cause of Death;Cell Death;Cells;chemotherapeutic agent;chemotherapy;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Cytotoxic agent;Dimerization;Doxorubicin;Drug Efflux;Drug Interactions;Enzymes;erastin;Failure;Family;Fluorescence;genetic analysis;Goals;Histone Deacetylase Inhibitor;human tissue;Imidazole;inhibitor;Ketones;kinase inhibitor;Knock-out;Length;Light;Lipid Peroxidation;Malignant Neoplasms;malignant phenotype;Mediating;Melanoma;member;Molecular;multi drug transporter;Multi-Drug Resistance;multidrug resistant cancer;Mutate;nanoluciferase;Natural Product Drug;neoplastic cell;Oral;overexpression;Paclitaxel;Penetration;Pharmaceutical Preparations;Phenotype;Physiological;Piperazines;prevent;promoter;Proteins;Renal Cell Carcinoma;Reporting;Resistance;resistance mechanism;response;Rhodamine 123;Role;Site;small molecule;System;tool;Transcript;Transfection;Universities;uptake;Vinca Alkaloids;Work

PROJECT_TITLE: Genetic Analysis of the Multidrug Resistance Phenotype in Tumor Cells


NIH_SPENDING_CATS: Cancer;Genetics

PI_NAMEs: APPELLA, ETTORE  (contact)

PROJECT_TERMS: Acetylation;Adenocarcinoma Cell;Affect;Amyloidosis;anti-cancer treatment;Apoptosis;Apoptotic;Binding;Biochemical;Biological;Biophysics;Biotin;C-terminal;cancer cell;cancer stem cell;Cell Cycle Arrest;Cells;Cellular Stress;Chronic;cofactor;Collaborations;Colon Carcinoma;Critical Pathways;Cysteine;design;DNA;DNA Binding Domain;DNA Damage;DNA Repair;Enzymes;EP300 gene;Epigenetic Process;Esophageal Adenocarcinoma;Etoposide;Exhibits;experimental study;gain of function;Generations;Genetic Transcription;Goals;Growth;Heat-Shock Response;high throughput screening;Histones;Human;Hydroxylation;Hypoxia;Immune;immune cell infiltrate;improved;in vivo;Inflammatory;inhibitor;Lower Gastrointestinal Tract;Lysine;Mass Spectrum Analysis;MCF7 cell;Measures;Mediating;Metabolic;metabolic profile;Metabolism;Methylation;Modification;Molecular;Molecular Conformation;Mucous Membrane;mutant;Mutation;N-terminal;Neoplasm Metastasis;novel;Nuclear Extract;Nuclear Proteins;Oncogenic;Outcome;Peptides;peptidomimetics;Permeability;Phosphorylation;Point Mutation;Post-Translational Protein Processing;preference;prevent;Prognosis;Proteins;Publishing;Reaction;Regulation;Reporting;Repression;Research;response;Role;senescence;simulation;Site;small molecule;stem cell migration;Stimulus;Stress;Sumoylation Pathway;TP53 gene;Transactivation;Transcription Coactivator;transcription factor;Transcriptional Activation;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Suppressor Proteins;tumorigenesis;Ubiquitination;Work

PROJECT_TITLE: Tumor Suppressor Protein, p53