ORG_CITY: MANHATTAN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: KANSAS STATE UNIVERSITY

ORG_STATE: KS

PHR: Overall Project Narrative: Emerging infectious diseases are diseases that have newly appeared or whose incidence has increased in the past years or could increase in the near future; many emerging diseases are also zoonotic. This COBRE application will form a thematic center focused on Emerging and Zoonotic Infectious Diseases (EZID) and will study virulence factors and host-pathogen interactions in both in vitro systems and in animal models, using basic and translational research approaches, with support from two multi-user core facilities. The overarching goal is to develop a unique, nationally and internationally recognized Research Center on Emerging and Zoonotic Infectious Diseases at Kansas State University.

PI_NAMEs: RICHT, JUERGEN A (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Achievement;Address;Advisory Committees;Aging;Animal Diseases;Animal Model;Animals;Applications Grants;Area;Arts;Award;Basic Science;biosafety level 4 facility;Cell Culture Techniques;Centers of Research Excellence;Climate;Collaborations;college;Communicable Diseases;Core Facility;Development Plans;Disease;doctoral student;Emerging Communicable Diseases;Emerging infection;Ensure;Environment;Extramural Activities;Faculty;faculty mentor;Faculty Recruitment;Funding;Future;Goals;graduate student;Grant;Growth;Health;improved;In Vitro;Incidence;Infectious Diseases Research;Institution;inter-institutional;Interdisciplinary Study;interest;International;Island;Kansas;Laboratories;laboratory facility;medical schools;member;Mentors;Microbe;Mission;Molecular and Cellular Biology;Nebraska;novel therapeutics;novel vaccines;Participant;pathogen;Pathology;Pathway interactions;Persons;Pilot Projects;Plum;Postdoctoral Fellow;Process;Productivity;programs;rapid growth;recruit;Research;research facility;Research Infrastructure;Research Institute;Research Personnel;Research Project Grants;Research Support;Resources;Retirement;Science;Secure;Security;Strategic Planning;success;symposium;synergism;System;Training;training opportunity;translational approach;Translational Research;United States National Institutes of Health;Universities;Veterinary Medicine;Viral;Virulence Factors;Work;Zoonoses


ADMINISTERING_IC: GM

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Infectious Diseases

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

PROJECT_TERMS: Achievement;Advisory Committees;Animal Model;Applications Grants;Area;Award;Biology;Biomedical Research;career development;Cellular biology;Centers of Research Excellence;Chemicals;Cognitive;Collaborations;Collection;Committee Members;Communicable Diseases;Core Facility;Dedications;Development;Development Plans;Disease Pathway;Ecosystem;Educational workshop;Emerging Communicable Diseases;Ensure;experience;Extramural Activities;Faculty;faculty mentor;Feedback;Funding;Future;Goals;graduate student;Grant;Growth;Head;Human Resources;Idaho;improved;Individual;Infectious Diseases Research;Infrastructure;interest;International;Kansas;Knowledge;laboratory facility;Manuscripts;Medical center;member;Mentors;Mission;Missouri;Molecular Analysis;Molecular Biology;Multiple Partners;Nebraska;Neurobiology;novel strategies;operation;pathogenic microbe;Pathology;Phase;Play;Policies;Postdoctoral Fellow;Principal Investigator;Procedures;Productivity;programs;protein function;protein structure;Qualifying;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;responsible research conduct;Role;Secure;Series;success;symposium;Technology;timeline;Training;Training Programs;United States National Institutes of Health;Universities;virology;Work;Writing;Zoonoses

PROJECT_TITLE: Administrative Core


PI_NAMEs: MOROZOV, IGOR  (contact)

PROJECT_TERMS: Animal Experimentation;Animal Experiments;animal facility;Animal Model;Animals;Antibodies;Area;Autopsy;Award;Biomedical Research;biosafety level 3 facility;biosecurity;Board Certification;Caring;Centers of Research Excellence;college;Communicable Diseases;comparative;Consultations;Containment;Core Facility;Development;Diagnostic;diagnostic development;Diagnostic tests;Ensure;Equipment;Evaluation;Experimental Designs;Experimental Pathology;experimental study;Extramural Activities;Funding;Goals;Hybridomas;IACUC;improved;Individual;Infrastructure;instrument;Investigation;Kansas;laser capture microdissection;Medicine;Methodology;Modeling;Molecular and Cellular Biology;pathogen;Pathologic;Pathologist;Pathology;Performance;Pilot Projects;Process;Protocols documentation;Reagent;Research;Research Design;Research Infrastructure;Research Institute;Research Personnel;Research Project Grants;Reservations;Rodent;sample collection;Sampling;Schedule;Services;single-cell RNA sequencing;success;synergism;System;Testing;Time;timeline;Tissue Banks;Tissue Sample;Training;Universities;Vertebrates;Veterinary Medicine;Work;Zoonoses

PROJECT_TITLE: Animal Model/Pathology Core


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Emergency Care;Health Services;Heart Disease;Neurosciences

ORG_CITY: DURHAM

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative In the United States, approximately 350,000 people suffer out-of-hospital cardiac arrest per year, and there is an urgent need to generate evidence on how to integrate effective treatments into a coordinated system of care at the community and state levels. Our study will test a customized strategic intervention program that focuses on community interventions to improve key process of care measures in the critical minutes after cardiac arrest. If successful, our intervention would provide a roadmap for communities throughout the United States to save lives and improve patient outcomes after cardiac arrest. 1

PI_NAMEs: AL-KHALIDI, HUSSEIN  (contact);MARK, DANIEL B

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: 18 year old;Adherence;Agreement;Cardiac;cardiovascular emergency;care providers;care systems;Caring;Categories;Cerebrum;Clinical;Clinical Research;Clinical Trials;Clinical Trials Data Monitoring Committees;Cluster randomized trial;Collaborations;Communities;community intervention;Country;County;Data;Data Collection;Data Coordinating Center;data integration;data management;data quality;Data Reporting;Data Set;data submission;Databases;design;dissemination trial;Doctor of Philosophy;Documentation;Dose;effective intervention;effective therapy;Effectiveness;Electric Countershock;electronic data;Elements;Emergency Care;Emergency medical service;Emergency response;Emergency Situation;Enrollment;Ensure;experience;Feedback;first responder;follow-up;functional status;Heart Arrest;Heterogeneity;Hospitals;implementation intervention;implementation trial;improved;improved outcome;incremental cost;Institute of Medicine (U.S.);Instruction;Intervention;intervention program;Leadership;Link;Manuals;Manuscripts;Measures;Medical;Monitor;National Heart, Lung, and Blood Institute;Nervous System Physiology;Neurologic;Neurological outcome;North Carolina;Observational Study;operation;out-of-hospital cardiac arrest;Outcome;Patient-Focused Outcomes;Patients;Performance;Persons;Phase;Population;Population Density;Preparation;primary endpoint;Principal Investigator;Procedures;Process;programs;Protocols documentation;Public Health;Quality Control;Quality of life;Race;Randomized;randomized trial;Registries;Reporting;Research Design;Research Institute;Research Personnel;Research Proposals;Resources;response;Resuscitation;Role;secondary outcome;Secure;Signal Transduction;Socioeconomic Status;standard care;Standardization;Statistical Data Interpretation;statistics;Survival Rate;Survivors;System;Techniques;Telephone;telephone coaching;Testing;Training;treatment as usual;trial design;United States;Variant;Work

PROJECT_TITLE: RACE-CARS DCC 2/2

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(JA)]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases

PI_NAMEs: HARDWIDGE, PHILIP ROSS (contact)

PROJECT_TERMS: Advisory Committees;Animal Model;Area;Biochemical;Biochemistry;Bioinformatics;Biological Assay;Biology;Biomedical Research;Biophysics;Cell Separation;Centers of Research Excellence;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;college;Committee Members;Communicable Diseases;Communication;Communities;Core Facility;CRISPR/Cas technology;Data;Data Set;Diagnostic;DNA sequencing;Doctor of Philosophy;Electron Microscopy;Employee;Environment;Equipment;equipment acquisition;experience;experimental study;Extramural Activities;Faculty;Financial Support;Flow Cytometry;Fluorescence Microscopy;Funding;Goals;graduate student;Growth;Image Cytometry;Imaging technology;improved;Individual;Infrastructure;innovation;instrument;Kansas;Laboratories;laser capture microdissection;Leadership;Maintenance;member;Mentors;Methodology;Modernization;Molecular;Molecular and Cellular Biology;next generation;pathogen;Pathogenesis;Pathology;Performance;Postdoctoral Fellow;programs;Research;Research Personnel;Research Project Grants;Resources;Services;single-cell RNA sequencing;synergism;Teacher Professional Development;Techniques;Technology;Time;Training;undergraduate student;Universities;vaccine development;Veterinary Medicine;Zoonoses

PROJECT_TITLE: Molecular and Cellular Biology Core


ADMINISTERING_IC: DK

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Dietary Supplements;Digestive Diseases;Infectious Diseases;Nutrition;Pediatric;Prevention

ORG_CITY: SAN ANTONIO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Project Narrative We will explore the relevance of vitamin B12 (VB12) in the regulation of the ileal epithelium homeostasis that may control pathogen infection causing intestinal tissue damage. The proposed research studies may provide important insights into VB12 ability to potentially improve the health of newborns through a sustainable therapeutic regimen.

PI_NAMEs: ZADEH, MANSOUR M (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: 5' Untranslated Regions;Adolescent;Adult;Aerobic;Affect;Bacteria;Binding;Biochemical Pathway;Birth;Cell Differentiation process;Cell Physiology;Cells;Child;Childhood;cofactor;Communities;Complex;Coupled;Cytoplasm;Dependence;Deterioration;Diet;Diet therapy;dietary;Disease;DNA;DNA Methylation;Ecosystem;enteric infection;enteric pathogen;epigenome;epigenomics;Epithelial Cells;Epithelium;Event;Fortification;Functional disorder;Future;genome integrity;Genome Stability;Genomics;Growth;gut bacteria;gut homeostasis;Helper-Inducer T-Lymphocyte;Homeostasis;Hypoxia;Immunomodulators;Immunosuppressive Agents;Impairment;improved;Incidence;Infection;Inflammation;Inflammatory Bowel Diseases;insight;Intestinal Diseases;Intestines;Intrinsic factor;intrinsic factor-cobalamin receptor;LDL-Receptor Related Protein 2;Macrophage;Malnutrition;Metabolic;Metabolic Pathway;metabolome;metabolomics;microbial;micronucleus;Micronutrients;Mitochondria;Modification;Molecular;Morbidity - disease rate;Mus;Neonatal;neonatal health;neonate;Newborn Infant;novel;novel therapeutic intervention;Nutritional;Operon;Oxygen;pathogen;Pathogenesis;Pathogenicity;Phagocytes;Pharmaceutical Preparations;postnatal period;Pregnancy;Premature Infant;prenatal;programs;Propionibacterium;receptor;Regimen;Regulation;Reporting;Research Proposals;research study;Respiration;response;Risk Factors;Risk Reduction;Role;Salmonella;Source;synergism;T cell response;Testing;Therapeutic;Tissues;Transcobalamins;transcriptome;transcriptomics;United States;Vitamin B 12;Vitamin B 12 Deficiency;vitamin biosynthesis;Vitamins

PROJECT_TITLE: Bacteria-associated VB12 regulates neonatal ileal epithelium homeostasis

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences;Pediatric

ORG_CITY: LEXINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Disruptions to the process of eye formation can result in ocular birth defects and pediatric blindness; although some of the genetic causes of ocular birth defects have been identified, we still don’t have a good understanding of exactly how mutations in these genes cause visual system dysfunction. In this grant proposal we will study the function of the chromatin remodeling factor CHD7 during eye development; these studies are important because loss of expression of CHD7 causes CHARGE syndrome (also known as CHD7 disorder), a genetic disorder that results in defects in the eyes, ears, heart, brain, nose, and genitourinary system. The results of our experiments will help us better understand the chain of events that leads to abnormal eye formation during embryonic development, and this knowledge may improve the identification, management, and treatment of congenital sight-threatening diseases.

PI_NAMEs: MARTIN, DONNA M.;MEYER, JASON STEPHEN;MORRIS, ANN C (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Applications Grants;ATAC-seq;Blindness;Brain;cell type;Cells;CHARGE syndrome;CHD7 gene;Childhood;Choanal Atresia;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Coloboma;Complex;Congenital Abnormality;Data;Data Set;Defect;Development;Disease;DNA Binding;Ear;Embryonic Development;Epigenetic Process;epigenetic regulation;epigenomics;Event;experience;experimental study;Eye;Eye Abnormalities;Eye Development;eye formation;Functional disorder;Gene Activation;Gene Expression;gene regulatory network;Genes;Genetic;Genetic Diseases;Genetic Transcription;Genitourinary system;Germ Lines;Growth;hearing impairment;Heart;Heart Abnormalities;helicase;Human;Image;improved;Individual;Knock-out;Knowledge;Mediating;Molecular;Morphogenesis;mouse genetics;mouse model;Mus;Mutagenesis;mutant;Mutation;Neural Crest Cell;neurogenesis;Nose;novel;Organoids;Pathogenesis;Pathogenicity;Phenotype;Photoreceptors;Process;Proliferating;Proteins;Retina;Retinal Cone;retinal imaging;retinal progenitor cell;Role;Structure;Syndrome;Testing;Transcriptional Activation;transcriptome sequencing;transcriptomics;Variant;Vertebrate Photoreceptors;Vision;Visual impairment;Visual System;Zebrafish

PROJECT_TITLE: Functions of chromatin remodeler Chd7 in retinal cell development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-M(02)M]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE This study will utilize a large (N=307,719) dataset from the UK Biobank cohort and will apply advanced causal machine learning methods, specifically the honest causal forest/policy tree, doubly robust adaptive LASSO, and Bayesian Adaptive Regression Trees (BART), to identify novel effect modifiers and heterogeneous subgroups for the relationship between statin use and the risk for Alzheimer’s disease and related dementias (ADRD). This F31 application will help me to gain valuable training in causal machine learning methods and cognitive aging, while also pursuing my goal of becoming an independent investigator.

PI_NAMEs: JAWADEKAR, NEAL  (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: advanced dementia;Affect;Age;aged;Aging;Algorithms;Alzheimer's disease related dementia;Alzheimer's disease risk;American;apolipoprotein E-4;Award;Behavioral;biobank;Biological;Biological Markers;career;Characteristics;Clinical;Clinical Trials;Cognitive aging;cognitive function;cohort;comorbidity;Consensus;Data;Data Set;Dementia;dementia risk;design;Diagnosis;Disease;Economics;effective therapy;Effectiveness;follow-up;forest;Genetic;Goals;Grant;Heterogeneity;Hyperlipidemia;Impaired cognition;improved;Individual;innovation;interest;Investigation;lipid metabolism;Machine Learning;machine learning algorithm;machine learning method;Mentorship;Methods;Mission;Modification;Nature;novel;Observational Study;optimal treatments;Participant;patient subsets;Pharmaceutical Preparations;Policies;precision medicine;Prevalence;prevent;Prevention;Prevention Research;Prevention strategy;Probability;Prospective cohort;Psychometrics;Public Health;Qualifying;Race;recruit;regression trees;Reproducibility of Results;Research;Research Methodology;Research Personnel;Research Proposals;Research Training;Resources;Risk Reduction;Sampling;sex;skills;social;sociodemographics;study population;Subgroup;Testing;Training;treatment effect;Trees;United States

PROJECT_TITLE: Data-Driven Discovery of Heterogeneous Treatment Effects of Statin Use on Dementia Risk

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-L(20)L]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lung;Lung Cancer;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative This proposal tests the efficacy of a phone-based tobacco cessation intervention for people living with HIV (PLWH) in comparison to the standard of care (brief advice to quit) and nicotine replacement therapy (nicotine patches) in Uganda and Zambia. Our study will provide insight into the efficacy, feasibility, applicability, and affordability of delivering tobacco cessation interventions through health care professionals at HIV treatment centers in two countries with different tobacco use patterns, policy environments, and health care resources. The previously tested SMS-platform to be used in our study is uniquely positioned to be scaled in low- and middle-income countries worldwide, in which case rigorous research showing even modest success in reducing the prevalence of tobacco consumption among PLWH could confer substantial health and economic benefits.

PI_NAMEs: WIPFLI, HEATHER L (contact)

PROGRAM_OFFICER_NAME: CORREA-MENDEZ, MARGARITA

PROJECT_TERMS: Abstinence;Acquired Immunodeficiency Syndrome;Africa;Africa South of the Sahara;African;Alcohol consumption;Anti-viral Therapy;attributable mortality;Awareness;Behavioral;Biochemical;brief advice;Cardiovascular Diseases;Cause of Death;Chronic Obstructive Pulmonary Disease;co-infection;Communities;comorbidity;comparative;comparative efficacy;cost effective;cost effectiveness;cost estimate;cost-effectiveness ratio;Country;Data;depressive symptoms;design;Disease;disorder risk;Economics;efficacy evaluation;efficacy testing;Enrollment;Ensure;Environment;General Population;Goals;Health;Health behavior;Health Personnel;Health Professional;Healthcare;HIV;improved;incremental cost;incremental cost-effectiveness;insight;interest;Intervention;intervention effect;low and middle-income countries;Low income;low income country;Lung;Malignant Neoplasms;Measures;medical schools;Mental Health;mHealth;Morbidity - disease rate;mortality;Nicotine Dependence;nicotine patch;nicotine replacement;nicotine treatment;Outcome;Participant;Patient Self-Report;Pattern;Persons;pharmacologic;Pneumonia;Policies;Policy Maker;Population;Positioning Attribute;Prevalence;programs;Provider;Public Health Schools;Randomized;Randomized, Controlled Trials;Research;Resources;Risk;Risk Factors;scale up;secondary outcome;Services;Smoke;Smoker;Smoking;Social isolation;social stigma;standard of care;success;Telephone;Testing;Text Messaging;therapy adherence;Time;Tobacco;tobacco cessation intervention;tobacco control;Tobacco use;Tobacco Use Cessation;tobacco user;treatment arm;treatment center;Tuberculosis;Uganda;Universities;World Health Organization;Zambia

PROJECT_TITLE: Quit4Life+: Adapting and Evaluating a Phone-Based Tobacco Use Cessation Program for People Living with HIV in Uganda and Zambia


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Climate-Related Exposures and Conditions;Genetics;Infectious Diseases;Prevention;Sexually Transmitted Infections;Skin Cancer

PHR: Project Narrative: To best respond to emerging viruses, all potential pathogenic mechanisms must be appreciated. Inhibition/degradation of p53 and pRB are established ways that viruses can be oncogenic, but others likely exist. This project examines the mutagenic and oncogenic potential of p300 inactivation using cutaneous human papillomaviruses as a model.

PI_NAMEs: WALLACE, NICHOLAS A (contact)

PROJECT_TERMS: Animal Model;Attenuated;attenuation;Biochemical;BRCA1 gene;BRCA2 gene;Bypass;Cancer Etiology;cancer risk;Cell Culture Techniques;Cell Cycle;Cell Cycle Regulation;Cells;Centrosome;Characteristics;Chromosome Segregation;Chromosomes;chronic infection;cofactor;Communicable Diseases;Complex;crosslink;Cutaneous;Data;Dependence;Disease;DNA;DNA Double Strand Break;DNA Interstrand Cross-Link Repair;DNA Interstrand Crosslinking;DNA Intrastrand Crosslinking;DNA Repair;DNA replication fork;Double Strand Break Repair;Emerging Communicable Diseases;emerging pathogen;emerging virus;EP300 gene;Epidemiology;Epidermodysplasia Verruciformis;Event;experience;Exposure to;Failure;Fanconi's Anemia;FDA approved;Formulation;Frequencies;G2 Phase;Gene Expression;General Population;Genes;Genetic Materials;Genome;Genomic Instability;Goals;Growth;Human Genome;Human papilloma virus infection;Human Papilloma Virus Vaccine;Human Papillomavirus;human pathogen;Immunosuppression;Impairment;improved;Infection;Infectious Agent;inhibitor;insight;Link;Malignant - descriptor;Malignant Neoplasms;Mitosis;Modeling;Molecular Biology;Mutation;novel;Oncogenic;pathogen;Pathogenicity;Pathway interactions;Patients;Polymerase;Post-Translational Protein Processing;pressure;prevent;Process;protein degradation;Proteins;Publishing;Regulation;Repair Complex;repaired;Repression;Research;Resolution;response;Retinoblastoma Protein;Risk;Risk Assessment;Role;S phase;Signal Transduction;Skin;Skin Carcinoma;Societies;stem;Sun Exposure;Sunscreening Agents;System;Techniques;Technology;Testing;TP53 gene;transcription factor;Tropism;tumor;Tumor Suppressor Proteins;tumorigenesis;tumorigenic;ultraviolet damage;Ultraviolet Rays;UV induced;UV sensitive;Viral;Viral Genes;Viral Proteins;Virus;Virus Diseases;World Health Organization;Zoonoses

PROJECT_TITLE: Cutaneous Human Papillomavirus as a Novel Model of Viral Oncogenesis


ORG_CITY: LA JOLLA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Komor – Project Narrative – “Development and Application of New Genome Editing Tools for the Functional Investigation of Genetic Variants of Uncertain Significance”  Our inability to interpret the clinical consequences of genetic variants discovered by sequencing remains a critical obstacle to the progress of precision medicine: out of the 4.6 million missense variants identified in the Genome Aggregation Database, over half are admitted to be variants of uncertain significance (VUS). New methods capable of interpreting VUS would not only enhance the efficacy of current therapies by better informing patient selection strategies, but also accelerate the development of new approaches to combat diseases with a genetic component. Here we propose the development of new genome editing tools and platforms that will allow researchers to functionally interrogate thousands of VUS individually, in combination, and in aggregate, to produce clinically-relevant information on how genetic variations cause human disease.

PI_NAMEs: KOMOR, ALEXIS C. (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Acceleration;Adenine;Admission activity;aggregation database;Area;base editing;base editor;Base Pairing;Bioinformatics;Cells;Chemicals;Chemistry;Clinical;clinically relevant;combat;Communities;CRISPR/Cas technology;Cytosine;Deamination;design;Development;Directed Molecular Evolution;Disease;DNA Double Strand Break;Enzymes;Gene Mutation;Genetic;Genetic Diseases;genetic variant;Genetic Variation;Genome;genome editing;Genomic DNA;human disease;Human Genetics;Individual;interest;Investigation;Methodology;Methods;Modification;novel strategies;nucleobase;Pathogenicity;Patient Selection;Point Mutation;precision medicine;programs;Research;Research Personnel;Single-Stranded DNA;Time;tool;Variant;variant of unknown significance;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: MINNEAPOLIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative: We and others have identified resident memory T cells in secondary lymphoid organs (SLO TRM). Despite their broad distribution after systemic infection in mice and seeming abundance in human lymph nodes, the roles of SLO TRM in immunity have not been investigated. This proposal will evaluate the abundance and microanatomical location of SLO TRM after diverse pathogen experience, the migratory fate and developmental potential of SLO TRM upon reactivation, and the protective functions of SLO TRM.

PI_NAMEs: O'FLANAGAN, STEPHEN D (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: adaptive immunity;Address;Anatomy;Antigens;Basic Science;Biology;biomarker identification;Blood;Cancer Biology;career;CD8-Positive T-Lymphocytes;cell motility;Cells;Cellular biology;Data;Dendritic Cells;density;Deposition;Development;developmental plasticity;Disease;Doctor of Philosophy;effector T cell;emerging pathogen;Environment;experience;Faculty;Fellowship;Focal Infection;Goals;HIV;Home;Homing;Human;Immune response;Immunity;Immunologic Memory;Immunologic Surveillance;Immunology;Infection;innovation;Institution;Intestines;intravital microscopy;Investigation;Laboratories;Location;Lymph;lymph nodes;Lymphocyte;Malaria;Mediating;Memory;Mentors;Mesentery;Microanatomy;Microbe;microbial;Microbiology;Microscopy;migration;Minnesota;Modeling;mouse model;multi-photon;Mus;novel vaccines;Operative Surgical Procedures;Parabiosis;pathogen;pathogen exposure;Pathogenicity;Perception;Phenotype;Play;Population;Positioning Attribute;pre-doctoral;programs;Proliferating;Property;rapid detection;Research;residence;Residencies;Role;Scientist;secondary lymphoid organ;Serology;Signal Transduction;Site;Skin;Systemic infection;T memory cell;T-Lymphocyte;Techniques;Testing;Therapeutic;tissue resident memory T cell;Tissues;Training;Transplantation;Tuberculosis;Universities;Vaccination;Vaccine Design;Vaccines;Viral;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Investigating the Abundance, Fate, and Function of Secondary Lymphoid Organ Resident Memory T cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07B-U(20)]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences;Patient Safety

ORG_CITY: TEANECK

ORG_NAME: F SQUARE MEDICAL LLC

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Ocular anterior chamber paracentesis (ACP) has the potential to transform the standard of care in ophthalmology. For decades ACP has saved countless patients from irreversible blindness by alleviating acutely elevated intraocular pressure, and now pioneering labs are recognizing aqueous humor as a reservoir rich in diagnostic and predictive biomarkers. Unfortunately, there is no instrument specifically designed for ACP; instead, off-the-shelf tuberculin syringes with excessively long needles and cumbersome handling are repurposed with serious risks of intraocular trauma, poorly controlled aspiration rates, unpredictable fluid volumes, and often require an assistant. To address this major and urgent unmet medical need, F Square Medical is developing and commercializing the first-ever instrument designed and optimized for ACP: Parasafe™.

PI_NAMEs: FARAH, SAMER  (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: Acute;Address;Adult;Advanced Development;Age related macular degeneration;American;Angle-Closure Glaucoma;anterior chamber;aqueous;Aqueous Humor;aspirate;Biological Markers;Blindness;Caring;Cataract;Chronic;Ciliary Body;Clinical;Collaborations;commercialization;Consensus;Cornea;Corneal Endothelium;Data;design;design verification;Development;Development Plans;Device or Instrument Development;Devices;Diabetic Retinopathy;Diagnosis;diagnostic biomarker;Diagnostic Procedure;disability;Disease;disease diagnostic;Drug Monitoring;Economic Burden;Endophthalmitis;Evaluation;experience;Exudative age-related macular degeneration;Eye;Eye diseases;Eye Injuries;Family suidae;Feedback;Freezing;Generations;Glaucoma;Goals;Hand;Hyphema;Iatrogenesis;improved;individualized medicine;Injury;innovation;instrument;Intervention;intravitreal injection;Iris;Legal patent;lens;Liquid substance;Lymphoma;manufacture;manufacturing run;Medical;Medical Device;meetings;Methods;Modeling;Modernization;Monitor;Needles;Ophthalmologist;Ophthalmology;Output;Paracentesis;Participant;Patient Care;Patient-Focused Outcomes;Patients;Performance;Persons;Phase;phase 1 study;Physiologic Intraocular Pressure;Positioning Attribute;predictive marker;Procedures;Production;programs;prototype;Questionnaires;Readiness;Reproducibility;Retinal Detachment;Retinal Vein Occlusion;Retinoblastoma;Risk;Risk Reduction;Safety;Sampling;Selection for Treatments;standard of care;Sterility;Structure;success;Surgeon;Syringes;Techniques;tool;Trauma;Tuberculin;usability;Uveitis;Vascular Endothelial Growth Factors;Vision

PROJECT_TITLE: Development of the First-ever Safe and Effective Anterior Chamber Paracentesis Instrument to Treat and Diagnose Ocular Diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-M(12)B]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Obesity;Pneumonia and Influenza;Prevention;Vaccine Related

PI_NAMEs: DHAKAL, SANTOSH  (contact)

PROJECT_TERMS: adipokines;biological sex;Cells;Communicable Diseases;comorbidity;cytokine;experimental study;Female;Gonadal Steroid Hormones;human model;Immune response;Immunity;Inferior;Inflammatory;Influenza A virus;Influenza Therapeutic;Influenza vaccination;influenza virus vaccine;male;Mediating;mouse model;Mus;Non obese;obese person;Obesity;Outcome;Play;protective efficacy;Role;sex;Sex Chromosomes;Sex Differences;T cell response;Vaccination;vaccine-induced immunity;Viral Pathogenesis;Virus Diseases;Zoonoses

PROJECT_TITLE: Sex-specific effects of obestity on Influenza A virus infection and immunity


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: SYRACUSE

ORG_DEPT: PHYSICS

ORG_NAME: SYRACUSE UNIVERSITY

PHR: PROJECT NARRATIVE This research is relevant to public health because it seeks to advance our understanding of causes of birth defects. It investigates how physical and mechanical forces impact organogenesis, and specifically affect the vertebrate left-right organizer, as errors in left-right patterning are a common cause of birth defects. This project will identify mechanical mechanisms underlying organogenesis that may present new ideas to predict or prevent birth defects, and is therefore relevant to NIH’s mission to develop foundational knowledge to enhance health and reduce disability.

PI_NAMEs: AMACK, JEFFREY D;MANNING, MARY ELIZABETH LISA (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: 3-Dimensional;Ablation;Actomyosin;Address;Affect;Anterior;Architecture;Biochemical;Biological Models;Biomechanics;Biophysical Process;Biophysics;Cell model;cell motility;Cell Shape;Cells;Cellular biology;Collaborations;Complex;Congenital Abnormality;convergent extension;Cytoskeleton;Defect;Developmental Biology;Developmental Process;disability;Dorsal;Embryo;Embryonic Development;Environment;Epithelium;Extracellular Matrix;Formulation;Four-dimensional;Goals;Health;Image;Image Analysis;in vivo imaging;Individual;Knowledge;Lasers;Left;malformation;mathematical model;Mathematics;Measurement;mechanical force;mechanical properties;Mechanics;Methods;Mission;Modeling;Morphogenesis;morphogens;Motion;Movement;multidisciplinary;notochord;novel;Optics;Organ;Organ Model;Organogenesis;Output;particle;Pattern;Phenotype;Physics;predictive modeling;prevent;Prevention;programs;Public Health;Research;Resolution;Rod;Role;self organization;Shapes;Signal Transduction;Signaling Molecule;simulation;Structural Congenital Anomalies;Structure;Surface;Testing;three dimensional structure;Three-dimensional analysis;Time;Tissues;United States National Institutes of Health;Velocimetries;Vesicle;Work;Zebrafish

PROJECT_TITLE: Four-dimensional prediction and quantification of how physical forces impact organogenesis in zebrafish

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Narrative The goal of the PACT-D3 training program is focused on grooming the next generation of diverse, basic, and translational researchers with interests in cancer drug discovery and development. It will allow us to educate the next generation of investigators focusing both on pediatric and adult cancer drug discovery and development and is unique for the IU system and NCI.

PI_NAMEs: CLAPP, DAVID W;KELLEY, MARK R. (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Adult;Antineoplastic Agents;Childhood;drug development;drug discovery;Training Programs

PROJECT_TITLE: Pediatric and Adult Translational Cancer Drug Discovery and Development Training Program (PACT-D3)


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Narrative This proposal aims to determine whether the action potential operates as a mechanical, as well as electrical, pulse in myelinated axons. The planned research uses photoswitchable tethered ligands to control the mechanosensitive two-pore domain potassium channel TRAAK in order to investigate its contributions to action potential repolarization and propagation in myelinated axons of the optic nerve. This work has implications for the study of electric signaling, as a field, as well as for diseases of the node of Ranvier (e.g., multiple sclerosis, stroke, glaucoma).

PI_NAMEs: ELLEMAN, ANNA VIRGINIA (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Action Potentials;Acute;Axon;azobenzene;Binding Sites;Biochemical;Biophysics;Cells;Communication;Cysteine;Data;design;Development;Disease;Electrophysiology (science);Exhibits;experimental study;extracellular;flexibility;Functional disorder;Future;Glaucoma;Goals;Guillain Barré Syndrome;improved;inhibitor;Isomerism;Libraries;Ligands;Light;Location;Maleimides;Measures;mechanical force;Mechanical Stimulation;Mechanics;Mediating;Membrane;Molecular;Multiple Sclerosis;mutant;Nature;Nerve;Nervous System Disorder;Nervous System Physiology;Neurons;neurophysiology;Nodal;novel;Optic Nerve;Organic Chemistry;patch clamp;Pathology;Physiologic pulse;Positioning Attribute;Potassium;Potassium Channel;Process;Ranvier's Nodes;Refractory;Research;response;Role;screening;Series;Signal Transduction;Site;spatiotemporal;Specificity;Speed;Spinal Injuries;Stretching;Stroke;Swelling;Tetraethylammonium;tool;TRAAK channel;Viola;voltage;Work

PROJECT_TITLE: Determining the role of the mechano-activated potassium channel TRAAK at nodes of Ranvier


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Clinical Research;Osteoporosis;Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Osteoporosis medications are extremely effective in reducing hip and spine fractures, however, their use has declined dramatically over the past decade, partially due to concerns about a rare adverse event called atypical femur fractures (AFF). Our project, which includes data from 3 large, population-based studies of AFF, will help identify women at particularly high or low risk for AFF, facilitating the development of prediction models and risk score tools. These tools will enable providers to individualize their recommendations to patients about the use of these important medications for managing osteoporosis, balancing AFF risk against osteoporosis-related fracture prevention.

PI_NAMEs: ADAMS, ANNETTE L;BAUER, DOUGLAS C (contact);BLACK, DENNIS M

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Accounting;Address;adjudication;Adverse event;adverse outcome;analytical method;Benefits and Risks;bisphosphonate;Bone Density;California;Case Study;Characteristics;Clinical;clinical decision-making;clinical practice;clinical risk;cohort;Cohort Studies;Communication;comorbidity;Data;data harmonization;Data Pooling;Decision Making;design;Development;Drug usage;Epidemiology;epidemiology study;Equation;Equilibrium;Ethnic Origin;Etiology;evidence base;falls;Femoral Fractures;Fracture;fracture risk;Fright;Funding;Goals;high risk;Hip Fractures;Holidays;improved;Individual;individual patient;International;Intravenous;Joints;Longitudinal cohort study;Measures;Medication Management;Modeling;Morbidity - disease rate;mortality;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Needs Assessment;novel;Osteoporosis;osteoporosis with pathological fracture;Osteoporotic;Outcome;Patient Care;Patients;Pattern;Pharmaceutical Preparations;Pharmacy facility;Physical activity;Physicians;Policy Maker;population based;Population Study;predictive modeling;predictive tools;Prevention;programs;Provider;Publishing;Race;radiological imaging;Radiology Specialty;Recommendation;Records;Reporting;Risk;Risk Assessment;Risk Factors;risk prediction;risk prediction model;Safety;Sampling;Selective Estrogen Receptor Modulators;Spinal Fractures;Stress Fractures;Subgroup;targeted treatment;tool;treatment duration;treatment guidelines;treatment strategy;trend;Woman

PROJECT_TITLE: Pooling International Cohort Studies of Long-Term Bisphosphonate Use and Atypical Femur Fractures


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Digestive Diseases;Health Services;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Rotavirus remains a major source of morbidity and mortality in low- and middle-income countries, even despite the introduction of live oral rotavirus vaccines. In collaboration with researchers in Malawi and Ghana, we will use mathematical models combined with economic models to evaluate the potential impact and cost- effectiveness of different rotavirus vaccination strategies, including those based on next-generation neonatal and parenteral rotavirus vaccines. Our analysis will provide a validated platform for assessing the cost- effectiveness of different rotavirus vaccination strategies in low- and middle-income countries.

PI_NAMEs: PITZER, VIRGINIA E (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Accounting;Adopted;Age;Benchmarking;Cessation of life;Child;clinical predictors;Clinical Trials;Collaborations;Collection;Cost Analysis;cost effective;cost effectiveness;Cost Effectiveness Analysis;cost-effectiveness evaluation;Costs and Benefits;Country;Data;Data Collection;Decision Making;Development;Diarrhea;Disease;economic evaluation;Economic Models;Funding;Future;Gastroenteritis;Ghana;Health;health economics;Heterogeneity;Immune response;Immunity;Immunization Programs;immunogenicity;Incidence;Income;Individual;Inpatients;Intussusception;Licensing;low and middle-income countries;low income country;Malawi;mathematical model;Measures;Modeling;Morbidity - disease rate;mortality;Neonatal;next generation;novel;novel strategies;novel vaccines;Oral;oral vaccine;Outpatients;Population;Positioning Attribute;Predisposition;Price;randomized, clinical trials;Research Personnel;response;Risk;Rotavirus;Rotavirus disease;Rotavirus Vaccines;Serious Adverse Event;Site;Source;Statistical Models;Structural Models;Subunit Vaccines;success;surveillance data;Time;Translating;transmission process;Uncertainty;Vaccination;vaccination strategy;vaccine candidate;vaccine effectiveness;vaccine response;vaccine strategy;Vaccines;Virus;willingness to pay

PROJECT_TITLE: Modeling the impact and cost-effectiveness of next-generation rotavirus vaccine strategies in low- and middle-income countries

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(90)]


NIH_SPENDING_CATS: Aging;Contraception/Reproduction;Genetics;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAINT LOUIS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Relevance to public health: Adult stem cells maintain and rejuvenate tissues by producing new cells to augment and replace existing cells, and during aging, the activity of stem cells progressively declines, which contributes to age-related tissue degeneration. To understand this process and stimulate the development of new approaches to sustain stem cell activity and improve human health, I will define mechanisms of adult stem cell failure during aging in the germline of a small animal, Caenorhabditis elegans. The results will address fundamental gaps in our knowledge of adult stem cell exhaustion and advance the fields of stem cell and reproductive aging.

PI_NAMEs: ANDERSON, AARON MARCUS (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Address;Adult;adult stem cell;Afferent Neurons;Age;age related;age related changes;age related decline;Aging;Alleles;Animals;Binding;Binding Sites;Caenorhabditis elegans;Cell Maintenance;Cells;Development;Dexamethasone;Distal;Ectopic Expression;egg;Epitopes;Event;Evolution;experimental study;Failure;Foundations;gain of function;Gene Expression;Genes;Genetic;Germ Lines;germline stem cells;glucagon-like peptide 1;Goals;Gonadal structure;granulysin;hallmarks of aging;Health;healthspan;healthy aging;Human;improved;in vivo;innovation;Intervention;juvenile animal;Knowledge;life span;Ligands;Logic;Mammals;mature animal;Mediating;Meiosis;Methods;model organism;Modeling;Molecular;Monitor;Neurons;neurotransmission;notch protein;Notch Signaling Pathway;novel strategies;Pathway interactions;Physiology;precursor cell;preservation;Process;Production;progenitor;promoter;protein expression;Public Health;Reagent;receptor function;Regulation;Rejuvenation;Reporting;Reproduction;reproductive senescence;Research;Scientist;Signal Transduction;skills;sperm cell;stem cell aging;stem cell biology;Stem Cell Development;stem cell exhaustion;stem cell function;stem cell niche;stem cell self renewal;stem cells;Structure;System;Testing;tissue degeneration;tissue repair;Tissues;tool;Training;transcription factor;Transforming Growth Factor beta

PROJECT_TITLE: Control of reproductive aging by germline stem cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE Glaucoma is a complex, multifactorial disease characterized by a slow and progressive degeneration of the optic nerve, leading to visual impairment. Despite the widely appreciated disease relevance of neuroinflammation and mitochondrial dysfunction as critical pathogenic elements, the mechanisms underlying glia-mediated neuroinflammation and the contribution of compromised mitochondrial network and function in glaucoma remain unknown. The proposed study explores novel pathways of potential links between AIBP and neuroinflammation, cholesterol efflux and mitochondrial function, and develops new therapy for glaucoma

PI_NAMEs: CHOI, SOO-HO ;JU, WONKYU  (contact);KIM, KEUNYOUNG

PROGRAM_OFFICER_NAME: HENLE, STEVEN JOHN

PROJECT_TERMS: adenovirus mediated delivery;Apolipoprotein A-I;ATP-Binding Cassette Transporters;Autophagocytosis;Axon;Binding;Binding Proteins;Bioenergetics;Biological Assay;Blindness;Cell Communication;Cell Death;Cell Survival;Cells;Cholesterol;Cholesterol Homeostasis;Clinical Research;Coculture Techniques;Complex;complex IV;cytochrome c oxidase;Development;Dimerization;Disease;Electroretinography;Elements;experimental study;extracellular;Flow Cytometry;Functional disorder;Genes;Genus Hippocampus;Glaucoma;Histologic;Histological Techniques;Human;Imaging technology;In Vitro;in vivo;Inflammasome;Inflammatory;Inflammatory Response;Interleukin-1 beta;intravitreal injection;Link;LOC118430 gene;Measures;Mediating;Membrane;Membrane Microdomains;Methods;Microscopic;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Mixed Function Oxygenases;Molecular;Molecular Analysis;Muller's cell;Mus;Nerve Degeneration;Neuroglia;neuroinflammation;neuroprotection;novel;novel therapeutics;Optic Nerve;optic nerve disorder;Oxidative Phosphorylation;Oxidative Stress;Pathogenesis;Pathogenicity;Pathway interactions;Pattern;Physiologic Intraocular Pressure;Play;preservation;pressure;prevent;Primary Open Angle Glaucoma;Process;Protein Deficiency;protein expression;Protein Overexpression;Protein Secretion;Proteins;receptor;Recombinants;Recovery of Function;Regulation;Respiration;response;Retina;Retinal Ganglion Cells;Role;Signal Transduction;Single Nucleotide Polymorphism;Stress;Synapses;System;Technology;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;TLR4 gene;tomography;Variant;vector;Vision;Visual evoked cortical potential;Visual impairment;Visual Pathways;Visual System;Work

PROJECT_TITLE: AIBP-mediated neuroprotection in glaucomatous optic neuropathy

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Genetics

PHR: This study focuses on identifying the key proteins required to assemble a fully-functional phage nucleus and determining the roles that they play in phage replication. The work proposed here will provide new insight into the biology of these understudied viruses and the underlying principles of subcellular compartmentalization previously observed almost exclusively in eukaryotes.

PI_NAMEs: POGLIANO, JOSEPH A (contact);POGLIANO, KIT J;VILLA, ELIZABETH

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Bacteriophages;Biochemistry;biological systems;Biology;candidate identification;Capsid;Cell Nucleus;Cells;Cellular biology;Complex;Cryo-electron tomography;Cytoplasm;Data;design;DNA biosynthesis;DNA Packaging;DNA Repair;Docking;Escherichia coli;Eukaryota;Filament;Genetic;Genetic Recombination;Genetic Transcription;Genome;Goals;In Situ;In Vitro;Individual;Infection;insight;knock-down;Knowledge;live cell imaging;Membrane;Membrane Lipids;Messenger RNA;Metabolism;Molecular and Cellular Biology;mRNA Export;nucleotide metabolism;Play;Process;Protein Biosynthesis;protein expression;Protein Import;protein metabolism;Proteins;Pseudomonas;Pseudomonas aeruginosa;Research;Resolution;Role;segregation;self assembly;structural biology;Structure;Surface;Translation Process;Tubulin;Viral;Virus;Work

PROJECT_TITLE: Molecular and cellular biology of the phage nucleus and spindle

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Infectious Diseases;Neurosciences;Rare Diseases

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE Human cytomegalovirus (HCMV) is the causative agent of CMV retinitis (CMVR), which is known to cause blindness. In this grant, I propose to develop a computational model of HCMV lytic and persistent-like replication kinetics. The findings from this research will advance the understanding of HCMV biology and the pathogenesis of CMVR for both scientists and clinicians by providing (1) a dynamic computational model of the complex lytic replication cycle, and (2) predictive quantitation of the response of a persistence-like HCMV infection in adult retinal pigment epithelial cells to antivirals.

PI_NAMEs: MONTI, CHRISTOPHER E (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Accounting;Adult;Anti-viral Agents;Behavior;Biochemical;Biological Models;Biology;Blindness;Blood Tests;career;cell type;Cells;Characteristics;Chemicals;chronic infection;Clinical Data;Complex;Computer Models;computer studies;cost;Cytolysis;Cytomegalovirus;Cytomegalovirus Infections;Cytomegalovirus Retinitis;Data;Dependence;detection limit;Diagnosis;Diagnostic;DNA biosynthesis;effective intervention;Fellowship;Fibroblasts;Ganciclovir;Goals;Grant;Growth;Human;Human Characteristics;human model;Immunocompromised Host;In Vitro;in vitro Model;Individual;Infection;Investigation;Kinetics;Knowledge;latent infection;Life;Life Cycle Stages;Lytic;lytic replication;Methodology;Modeling;models and simulation;Nature;neural;novel;Ophthalmologist;Outcome;Pathogenesis;Pathologic;Pathology;Patients;Pharmaceutical Preparations;Population;Production;protein expression;Proteins;Recovery;Regulation;Research;response;Retina;Risk;Sampling;Scientist;Sepsis;skills;Structure of retinal pigment epithelium;Syndrome;System;Techniques;Testing;therapeutically effective;Time;Training;treatment duration;Variant;viral DNA;Viral Genome;Viral Proteins;viral RNA;Viremia;Virion;Virus;Virus Replication;Vision;Visual;Western Blotting

PROJECT_TITLE: Bottom-up and top-down computational modeling approaches to study CMV retinitis


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: BOSTON

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE We will study different kinds of medical illustrations used in patient education materials to understand the impact these have on patient understanding and anxiety. We will also develop a conversational agent that can explain patient education documents to people, and evaluate different versions of the agent in an experiment to determine which version leads to the most learning.

PI_NAMEs: BICKMORE, TIMOTHY W. (contact);PAASCHE-ORLOW, MICHAEL

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: 3-Dimensional;Adult;Age;animation;Anxiety;anxiety states;Behavior;biomedical informatics;Characteristics;chatbot;Clinical Trials;Comprehension;Computer Interface;Computer Literacy;Computers;Cultural Backgrounds;design;Dimensions;Disease;Educational Materials;Electronics;Elements;Ethnic Origin;Evaluation;Exhibits;experience;experimental study;Explosion;Gender;Health;Health Educators;health literacy;Health Personnel;Health Status;Healthcare;Human body;human subject;Individual;Industry;Informatics;innovation;Internet;Intuition;Knowledge;Language;Learning;Linguistics;Medical;Medical Education;Medical Illustration;Medical Imaging;Medical Informatics;Modeling;Natural Language Processing;non-verbal;Online Systems;Ontology;Organ;Participant;Patient Education;Patients;Persons;Printing;Procedures;Public Domains;Race;radiological imaging;Randomized;randomized trial;Reading;Research;Retrieval;Science;Series;Source;Spanish;success;Techniques;Testing;tool;verbal;virtual health;virtual reality;virtual reality environment;web page

PROJECT_TITLE: Advancing Medical Illustration in Patient Education Materials: from Art to Science

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: DAVIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Transcription is a necessary process for gene expression, which results in a copy of RNA from the DNA template. In some cases, the RNA can intertwine with the DNA, forming a structure called an “R-loop.” This project will explore how abnormal R-loop formation leads to severe DNA damage by utilizing unbiased genomics approaches.

PI_NAMEs: VIERA, TALYSA C (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Address;Binding;Bioinformatics;Body Regions;career;Cell model;Cells;Complex;Defect;Disease;DNA;DNA Damage;DNA Double Strand Break;DNA Structure;Enzymes;Excision;Frequencies;Future;gene conservation;Gene Expression;Gene Expression Process;Genes;Genetic Transcription;Genome;Genome Stability;genome-wide;Genomic approach;Genomic Instability;genomic locus;Genomics;Goals;Hybrids;in vivo;Institution;Intellectual functioning disability;Knowledge;Lead;Link;Maintenance;Malignant Neoplasms;mammalian genome;Maps;Measures;Mediating;Metabolism;Molecular;mRNA Precursor;mutant;Nervous System Disorder;novel;Nuclear Export;Outcome;overexpression;Pancreatic ribonuclease;Pathway interactions;Pattern;Phenotype;poly A specific exoribonuclease;Polymerase;post-doctoral training;Process;promoter;Promoter Regions;Research Personnel;Research Proposals;Resolution;ribonuclease H1;RNA;RNA Polymerase II;RNA Processing;Role;Single-Stranded DNA;skills;Source;Structure;Testing;Time;Torpedo;Transcript;transcription termination;Work

PROJECT_TITLE: Investigating the connection between aberrant R-loop formation and genome instability

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-A(20)L]


ORG_CITY: SANTA CRUZ

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: PROJECT NARRATIVE New technologies have identified translation from previously overlooked short open reading frames. Micropeptides translated from these open reading frames have been shown to contribute to important biological processes including cancer, development and inflammation. This project seeks to identify micropeptides that are important to innate immunity and inflammation, which may have important scientific and therapeutic, implications.

PI_NAMEs: MALEKOS, ERIC  (contact)

PROJECT_TERMS: 3' Untranslated Regions;5' Untranslated Regions;adenylate;Amino Acids;Binding;Binding Proteins;Biological Process;Bone Marrow;Cell Line;Cell Nucleus;Cell Separation;Cell Survival;Characteristics;Chronic;circular RNA;Classification;Code;Communities;CRISPR screen;CRISPR/Cas technology;cytokine;Cytoplasm;Darkness;Data Set;Detection;Development;Disease;DNA;Endotoxins;Eukaryota;Exhibits;experimental study;Genes;Genetic Transcription;Genome;genome annotation;Goals;Growth;heuristics;Host Defense;Human;Immunity;Individual;Inflammation;Inflammatory;Inflammatory Response;interest;Interferons;Length;Link;Lipopolysaccharides;Macrophage;Malignant Neoplasms;Mass Spectrum Analysis;Messenger RNA;Modeling;Mus;Myeloid Cells;Natural Immunity;new technology;next generation sequencing;NF-kappa B;novel;Nucleotides;Open Reading Frames;pathogen;Pathway interactions;peptide I;Peptides;Phenotype;Play;polypeptide;Polyribosomes;Process;Production;Proteins;Proteome;Publishing;Reporter;Ribosomal RNA;Ribosomes;RNA;RNA Splicing;Role;Saccharomyces cerevisiae;screening;Series;Signal Transduction;Structure;success;Technology;Testing;Therapeutic;therapeutic target;TLR4 gene;Transcript;transcriptome;Translating;Translations;Untranslated RNA;Validation;Work

PROJECT_TITLE: Identification and characterization of small open reading frames translated during inflammation


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE The growing need for identifying effective therapeutics for Alzheimer’s disease (AD) can be met by bettering our understanding of the biological mechanisms by which genetic variants modify disease risk. By combining human induced pluripotent stem cells and an innovative xenotransplantation method, this proposal seeks to investigate the impact of a candidate risk variant in the MS4A locus and its causal genes on the function of disease- implicated microglia. This study will provide a blueprint for translating findings of genomic studies from statistical associations to biological function and serve to elucidate the contribution of MS4A genes to disease susceptibility, suggesting a mechanism of action that can be used for future drug discovery.

PI_NAMEs: MUNCH, ALEXANDRA  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Affect;Age;Alleles;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer's disease therapeutic;Amyloid deposition;amyloid pathology;Animal Model;Binding;Binding Proteins;Binding Sites;Biological;Biological Assay;Biological Markers;Biological Process;Brain;career;causal variant;CCCTC-binding factor;Cell Culture Techniques;Cell Line;Cell Physiology;cell type;Cells;Central Nervous System;chromatin remodeling;Chromosome 11;Clustered Regularly Interspaced Short Palindromic Repeats;Cognition;Containment;cytokine;Data Set;Disease;Disease Progression;Disease susceptibility;disorder risk;drug development;drug discovery;Drug Targeting;effective therapy;Enhancers;epigenomics;Etiology;executive function;experimental study;Foundations;functional genomics;Future;Gene Cluster;Gene Expression;Gene Family;gene function;Genes;Genetic;Genetic Diseases;genetic variant;genome wide association study;Genomics;Genotype;Human;Human Genetics;human induced pluripotent stem cells;humanized mouse;Immune;Immune signaling;Immunologic Receptors;Impaired cognition;In Vitro;in vitro Model;in vivo;induced pluripotent stem cell;Injections;Innate Immune System;innovation;Integral Membrane Protein;Knock-out;Light;loss of function;Macrophage;Maps;Measures;Mediating;member;Membrane;Memory impairment;Memory Loss;Methods;Microglia;Morphology;mouse model;Mus;Myelogenous;Myeloid Cells;Nerve Degeneration;Neurodegenerative Disorders;new therapeutic target;novel;Nucleotides;Outcome;Pathologic;Phagocytosis;Phenotype;Play;precursor cell;Production;protective allele;Proteins;Public Health;Reactive Oxygen Species;Research;Research Personnel;response;Risk;risk variant;Role;selective expression;Senile Plaques;Signal Transduction;Single Nucleotide Polymorphism;single nucleus RNA-sequencing;skills;Statistical Study;stem cell model;stem cells;targeted treatment;tau-1;Techniques;Testing;therapeutically effective;Training;transcriptomics;Translating;Transplantation;TREM2 gene;Validation;Variant;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Uncovering the Role of the MS4A Gene Family in Alzheimer's Disease


NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Genetics;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stroke

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Aging causes a decline in neurogenesis and decreased ability for the brain to recover after injury and a better understanding of the processes that underlie this change would reveal new therapeutic targets which could be used to ameliorating age-related decline in stroke recovery, cognitive decline, and Alzheimer’s disease. This study is based on unbiased approaches to identify adhesion and migration genes and pathways that change with age that result in defects in neural stem cell adhesion and migration. It will functionally validate and perturb these genes or pathways, with the goal of improving neurogenesis and repair after stroke.

PI_NAMEs: ZHOU, OLIVIA YU (contact)

PROJECT_TERMS: Adhesions;Adhesives;Adult;Affect;Age;age related;age related changes;age related decline;age-related disease;Aging;aging brain;aging related;Alzheimer's Disease;Area;Automobile Driving;Biological Assay;Brain;Brain Diseases;Brain Injuries;Brain region;brain repair;Candidate Disease Gene;candidate identification;career;Cell Adhesion;cell motility;Cell Physiology;cell type;Cells;Cellular biology;Chromatin;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cognitive function;Coupled;Data;Data Analyses;Data Set;Defect;Development;Disease;Distal;effective therapy;experimental study;Future;Genes;Genetic;genetic manipulation;Genetic Transcription;genome-wide;Genomics;Goals;Hippocampus;Impaired cognition;improved;In Vitro;in vivo;Injury;injury and repair;injury recovery;insight;interest;Intervention;Mentors;migration;Molecular;mouse model;nerve stem cell;Nervous System Disorder;neuroblast;Neurodegenerative Disorders;neurogenesis;Neurology;neuromechanism;Neurons;new therapeutic target;Nucleic Acid Regulatory Sequences;old mice;Older Population;olfactory bulb;Pathway interactions;Patients;Phenotype;Physicians;Play;post stroke;Process;Proliferating;Protein Kinase;protein kinase inhibitor;Proteins;regeneration potential;Regulation;repaired;rho;Risk Factors;Role;Scientist;Signal Pathway;Site;skills;small molecule;stem cell aging;stem cell biology;stem cell function;stem cell migration;stem cell niche;Stroke;stroke model;stroke recovery;subventricular zone;Testing;Therapeutic;therapeutic target;Training;transcriptomics;Traumatic Brain Injury;Up-Regulation;Work

PROJECT_TITLE: Mechanisms underlying a decline in neural stem cell migration during aging


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Mental Health;Neurodegenerative;Neurosciences;Social Determinants of Health;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: Project Narrative Stroke is a leading cause of death, and social isolation, shown to increase mortality, has become a widespread exposure among the general population due to the COVID-19 pandemic. The goals of these studies are to identify sex differences, if any, in prior-SIS and stroke severity, to elucidate the mechanism by which prior-SIS affects stroke outcomes, and to identify potential therapeutic targets for severe stroke after a stressor such as social isolation. These goals are consistent with the mission of the National Institute of Neurological Disorders and Stroke, which is to find ways to ‘reduce the burden of neurological disease for all people’ through research on ‘the brain and nervous system’.

PI_NAMEs: ZARDENETA, MACY  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Acute;Acute Disease;Adhesives;Adult;Affect;Age;Animals;Area;Astrocytes;Awareness;Biological Assay;Blood;Blood - brain barrier anatomy;blood-brain barrier permeabilization;Brain;brain health;Brain Infarction;Cardiovascular Diseases;Cardiovascular system;Cause of Death;CCL3 gene;Cell Line;Cells;Central Nervous System;Cessation of life;Chronic Disease;clinically relevant;COVID-19;COVID-19 pandemic;cytokine;Data;Dementia;dementia risk;Dextrans;Disease;Dose;Endothelin-1;Excision;experience;Family;Family member;Female;Flow Cytometry;Fluorescein-5-isothiocyanate;Forelimb;Future;General Population;glial activation;Goals;Histologic;Histology;Hour;Housing;Human;Immune;Impaired cognition;Incidence;Infarction;Inflammation;Inflammatory;inhibitor;Injury;intraperitoneal;Intravenous;Ischemic Stroke;Label;language impairment;Learning;Long-Term Effects;Magnetic Resonance Imaging;male;Matrix Metalloproteinases;Measurement;Measures;Mediating;Memory;Microglia;middle age;Midlife women;Minocycline;Mission;Mobility decline;Modeling;mortality;mortality risk;National Institute of Neurological Disorders and Stroke;Nervous System;Nervous System Disorder;neuroinflammation;Neurology;novel;Obesity;object recognition;Occupational Therapy;Outcome;Patient Isolation;Patients;Perfusion;Persons;Phagocytosis;Pharmaceutical Preparations;Phase;physical process;Physical therapy;Physicians;Physiological;Population;post stroke;post stroke cognitive impairment;Procedures;Process;Proteins;Protocols documentation;RANTES;Rattus;Recovery;Research;Risk;Scientist;Serum;Severities;sex;sex as a biological variable;Sex Differences;social;Social Distance;Social isolation;Social Network;Stress;stressor;Stroke;stroke model;stroke outcome;stroke patient;Survivors;Techniques;Testing;therapeutic target;Tight Junctions;TLR4 gene;Training;vasoconstriction;Vibrissae;Weight;Work

PROJECT_TITLE: Sex differences in the effects of prior social isolation stress on stroke outcomes


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_DEPT: PHARMACOLOGY

PHR: Project Narrative The proposed project will test the novel hypothesis that aberrant vascular lipid metabolism is a component of Alzheimer’s disease (AD). To do so, I will identify the molecular changes to the brain vasculature in patients with AD and will then model these changes in mice to clarify their relevance to vascular function and AD pathophysiology. This study may provide meaningful insights into the role of the cerebral vasculature in dementias such as AD, and may reveal novel therapeutic avenues for patients with AD.

PI_NAMEs: HARVEY, SEAN SANDAS (contact)

PROJECT_TERMS: Affect;age related;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Amyloid beta-Protein;Blood;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood flow;Blood Vessels;blood-brain barrier disruption;blood-brain barrier function;Body Weight;Brain;brain endothelial cell;brain parenchyma;Brain region;Carbon Dioxide;Carotid Artery Ulcerating Plaque;Cell Line;Cells;Central Nervous System;central nervous system vasculature;Cerebral Amyloid Angiopathy;Cerebral cortex;cerebrovascular;cerebrovascular health;Cerebrovascular system;Chronic;Circulation;cohort;comparison control;Cortical vasculature;Data;Dementia;Disease;Down-Regulation;Endothelial Cells;Environment;Enzymes;Epilepsy;Etiology;extracellular;Extravasation;Fatty Acids;Functional disorder;Genotype;Global Change;Goals;Health;Hemorrhage;Homeostasis;Human;Impairment;in vivo evaluation;Inflammatory;Injury;insight;Ions;Link;lipid biosynthesis;lipid metabolism;lipidome;lipidomics;Lipids;Liquid Chromatography;long chain fatty acid;Magnetic Resonance Imaging;Metabolic;Modeling;Molecular;Morphology;mouse model;Movement;Multiple Sclerosis;Mus;Nature;Nerve Degeneration;Nervous System Disorder;neural;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuroglia;neuroinflammation;neuron loss;Neurons;new therapeutic target;novel;novel therapeutics;Nutrient;Organ;Oxygen;Pathogenesis;Peripheral;Permeability;Property;Proteome;Proteomics;Role;Senile Plaques;Series;Serum;Signal Transduction;Stroke;tandem mass spectrometry;Testing;Therapeutic;Tissues;Tracer;trafficking;transcriptomics;Transgenic Mice;Traumatic Brain Injury;United States;Vascularization;Waste Products

PROJECT_TITLE: The role of vascular lipids in Alzheimer's disease pathophysiology


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative Pulmonary arterial hypertension (PAH) is a severe disease with a delayed diagnosis and markedly elevated mortality. High-risk populations, such as those with known genetic defects, provide a unique opportunity to determine the features of susceptibility and resilience to PAH. This proposal will fundamentally overturn the prevailing understanding of PAH by creating molecularly-driven signatures of susceptibility and resilience, provide novel insight into disease severity, and potentially identify new therapeutic targets.

PI_NAMEs: AUSTIN, ERIC DOUGLAS;BRITTAIN, EVAN L (contact);HEMNES, ANNA R

PROGRAM_OFFICER_NAME: HAGHPANAH, SEPIDEH

PROJECT_TITLE: Risk and Resilience in Pulmonary Arterial Hypertension and Genetically Susceptible Individuals


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE While healthcare advances have more than doubled the average human lifespan in the last century, the accompanying loss of learning and memory with age significantly compromises quality of life. Therefore, uncoupling pathways that regulate lifespan and healthspan is critical for mitigating the increasing rate of cognitive decline in aged individuals, of which there are few effective treatments available. The proposed research will use the nematode worm C. elegans as a model to discover conserved mechanisms that slow the decline of learning and memory with age, with the ultimate goal of identifying new drug targets that boost healthspan in higher organisms.

PI_NAMEs: LEPTICH, EMILY JEAN (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Address;Afferent Neurons;Age;age related decline;Age-associated memory impairment;aged;Aging;aging population;animal old age;Animals;Association Learning;Behavior;Behavioral Assay;Caenorhabditis elegans;Candidate Disease Gene;Cells;Chemotaxis;Cognitive;Cognitive aging;Complex;Cyclic AMP Response Element;Cyclic AMP-Responsive DNA-Binding Protein;Data;druggable target;effective therapy;egg;gain of function mutation;Genes;Genetic Transcription;Goals;hatching;Health;Healthcare;healthspan;Homologous Gene;Human;Impaired cognition;improved;insight;Interneurons;Investigation;juvenile animal;knock-down;Knowledge;learned behavior;Learning;Life Expectancy;life span;Memory;Modeling;Molecular;mutant;Nematoda;neuronal circuitry;Neurons;Neuropeptide Gene;Neuropeptide Receptor;Neuropeptides;new therapeutic target;novel;Organism;Pathway interactions;Peptide Signal Sequences;Peptides;Phenotype;promoter;protein activation;Quality of life;receptor;Reporter;Research;RNA Interference;RNA interference screen;Role;Sensory;Signal Transduction;Site;Testing;therapeutic target;Transgenic Organisms;Visual;young adult

PROJECT_TITLE: Investigating neuropeptide signals that slow cognitive aging in C. elegans


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE This project seeks to determine the role of a novel and poorly understood population of inhibitory cells in a region of the brain known as the thalamus, which is critical for processing sensory information and controlling brain-wide rhythms. The short-term goal of this project is to determine how these cells process inputs to regulate activity within the thalamus. In the long-term, the results obtained from this study will advance our ultimate goal of understanding how mammals perceive sensory information, in addition to guiding the development and testing of targeted therapies.

PI_NAMEs: YI, JANE  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: 3-Dimensional;Address;Amplifiers;Arithmetic;Arousal;Attention;Behavior;Behavioral;Biophysical Process;Brain;brain control;Brain imaging;BRAIN initiative;Brain region;Calcium;Cannulas;career development;Cell Nucleus;Cell Physiology;cell type;Cells;Cellular Structures;Code;Communication;Complex;computational neuroscience;Computer Models;Computer Simulation;Data;Data Set;data-driven model;Dendrites;Detection;Development;Disease;Distal;Electroencephalography;Electrophysiology (science);Endowment;Evaluation;experimental study;Fellowship;Generations;Genetic Complementation Test;Glutamates;Goals;Home;Image;In Vitro;in vivo;in vivo imaging;Individual;insight;instrument;interest;Interneurons;Location;Mammals;Medial lemniscus;Mediating;member;millisecond;Modeling;multi-electrode arrays;multi-photon;multiphoton imaging;Mus;neural;neural circuit;Neurobiology;neuronal cell body;Neurons;next generation;novel;operation;Optics;optogenetics;Output;Pathologic;Pattern;Perception;Periodicity;Physiological;Play;Population;Positioning Attribute;Preparation;Process;Property;receptive field;reconstruction;response;Rodent;Role;Seizures;Sensory;sensory input;Shapes;Signal Transduction;Sleep;Slice;somatosensory;Source;Speed;Structure;Surface;Synapses;Synaptic Vesicles;targeted treatment;Techniques;temporal measurement;Testing;Thalamic Nuclei;Thalamic structure;Time;tool;Training;Trees;two-photon;Universities;Validation;vesicular release;Vibrissae;voltage;Work

PROJECT_TITLE: Functional interrogation of the mouse somatosensory thalamic interneuron in sensory perception and rhythmic states


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative Memory concerns are associated with lower quality of life and are the most common cognitive complaint amongst healthy older adults. False memory – remembering events differently than how they happened – and a bias toward semantic memory – memory for concepts – both increase across the lifespan, but it is not well understood how the bias toward semantic memory contributes to false memory increases. This proposal seeks to identify semantic contributions to false memory by directly linking semantic processing and neural pattern similarity to false memory in older adults.

PI_NAMEs: MOORE, ISABELLE LORRAINE (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Address;Age;Aging;Alzheimer's Disease;amnestic mild cognitive impairment;Attention;Behavior;Behavioral;Clinical;Cognitive;Cognitive aging;cognitive change;Cues;Data;Dementia;Episodic memory;episodic memory impairment;Event;experience;experimental study;Foundations;Functional Magnetic Resonance Imaging;Goals;healthy aging;Impaired cognition;improved;indexing;insight;Knowledge;life span;Link;Measures;Memory;Memory impairment;Mission;neural;neural patterning;neuroimaging;neuromechanism;older adult;Perception;Population;Predisposition;Quality of life;Research;Retrieval;Semantic memory;semantic processing;Semantics;spatiotemporal;Testing;Time;young adult

PROJECT_TITLE: The contribution of semantic bias to false memory in healthy aging


ORG_CITY: SEATTLE

ORG_NAME: INSTITUTE FOR SYSTEMS BIOLOGY

ORG_STATE: WA

PHR: NARRATIVE Systematic cancer screening has led to a surge of cases of clinically invisible “dormant” tumors, raising the im- portant question for every diagnosed patient of whether a microscopic lesion poses a risk of becoming an inva- sive cancer or not. This project is motivated by a new theory of complex systems that explains their “tipping point” behaviors and uses a new scheme of single-cell resolution molecular profiling of minuscule tumor cell populations and tunable mouse tumors to study how tipping point dynamics drives a dormant tumor to become destabilized and become poised between staying dormant or “taking-off” and grow. The new approach could be used to detect when the dormant tumor enters the phase of instability that precedes an escape from dor- mancy to become clinical.

PI_NAMEs: BROCK, AMY ;HUANG, SUI  (contact)

PROGRAM_OFFICER_NAME: MILLER, DAVID J

PROJECT_TERMS: Animal Model;Animals;Awareness;Behavior;Biological;Biological Markers;cancer cell;cancer genome;cancer invasiveness;Cell Count;Cell Density;cell dimension;Cell Physiology;Cells;Characteristics;Classification;Climate;Clinical;Complement;Complex;Cultured Tumor Cells;Data;Dependence;design;Detection;Diagnosis;driver mutation;dynamic system;Ecosystem;Event;Exhibits;experimental study;Exposure to;gene regulatory network;Genes;Genetic;genome sequencing;Goals;Growth;high dimensionality;In Vitro;in vivo;indexing;Indolent;Lesion;Link;Malignant Neoplasms;Mathematics;Measurable;Measures;Microscopic;Modeling;Molecular Profiling;mouse model;Mus;mutant;Mutation;neoplastic cell;non-genetic;novel strategies;old mice;Pathway interactions;Patients;Pattern;Phase;Phenotype;Population;Population Dynamics;Population Growth;Population Process;Pre-Clinical Model;prognostic;Recurrence;Regulatory Pathway;Relapse;Research Personnel;Resolution;Risk;Scheme;Screening for cancer;Signal Transduction;single cell analysis;single-cell RNA sequencing;Stochastic Processes;Stratification;System;Systems Theory;Testing;theories;Titrations;transcriptome;transcriptome sequencing;Translating;tumor;Tumor Escape;tumor progression;Work

PROJECT_TITLE: Instability of Cancer Cell States in Tumor progression (ICCS)

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: MONELL CHEMICAL SENSES CENTER

ORG_STATE: PA

PHR: HEALTH RELEVANCE The sense of smell plays a critical role in preferences and aversions for specific foods. The proposed research will combine machine learning techniques with high quality human psychophysics to create a model that can predict the smell of odorous molecules. This model will allow us to describe and control odors, which will increase our understanding of food preference and eating-related health and wellness.

PI_NAMEs: MAINLAND, JOEL D (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Acceleration;Algorithms;auditory stimulus;Characteristics;Chemical Structure;Chemicals;Code;Collection;Color;Communities;Complex;Complex Mixtures;computer monitor;Country;Data;Data Set;Descriptor;Detection;Development;disease diagnosis;Eating;Enrollment;experience;Face;Food;Food Preferences;Frequencies;group competition;Health;high dimensionality;Human;improved;in silico;interest;Ligands;Machine Learning;machine learning algorithm;Maps;Measurement;Measures;member;Methods;model building;Modeling;Modernization;Molecular Structure;neural;Neurosciences;Non-linear Models;novel;Numerical value;Odors;Olfactory Pathways;Perception;physical property;Play;predictive modeling;preference;Process;Psychophysics;receptor;Research;Research Personnel;Role;single molecule;Smell Perception;Stimulus;Techniques;Technology;Testing;Training;Translating;Vision;Visual;visual stimulus;Vocabulary;Work

PROJECT_TITLE: Predicting Human Olfactory Perception from Molecular Structure

STUDY_SECTION: CSS

STUDY_SECTION_NAME: Chemosensory Systems Study Section[CSS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: PURDUE UNIVERSITY

PHR: PROJECT NARRATIVE It is known that cerebrovascular health is a significant risk factor for Alzheimer’s Disease (AD) dementia, the current leading cause of dementia worldwide. In this project, we will develop cerebrovascular health metrics from resting-state functional MRI data of the human connectome project to first understand cerebrovascular changes in a typical aging population and then apply these metrics to a large AD dataset. This project aims to develop reproducible measures of cerebrovascular health and then assess the association of these metrics with the cognitive impairments seen in AD dementia.

PI_NAMEs: WRIGHT, ADAM M (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Acceleration;Affect;Age;Aging;aging population;Alzheimer's Disease;Alzheimer's disease care;Alzheimer's disease pathology;Alzheimer's disease risk;arterial spin labeling;arterial stiffness;Blood;Blood Vessels;Brain;Cardiac;cerebral artery;cerebrovascular;Cerebrovascular Circulation;cerebrovascular health;Cerebrovascular system;Cerebrum;Clinical;clinical care;Code;Cognition;cognitive function;cohort;Complex;connectome;connectome data;Data;Data Set;Dementia;Deterioration;Development;Disease Progression;Drainage procedure;Focused Ultrasound;Functional disorder;Functional Magnetic Resonance Imaging;functional MRI scan;Future;Goals;Health;hemodynamics;Human;human data;image processing;Imaging Device;imaging modality;Impaired cognition;Indiana;Individual;insight;Intervention;large datasets;Link;Magnetic Resonance Imaging;Maps;Measures;Mentorship;Microcirculation;Monitor;multidisciplinary;Neurons;Noise;novel;novel strategies;Outcome;Pathology;Peripheral;Persons;Physicians;Physiologic pulse;Physiology;Play;Prognosis;Property;Reproducibility;Research;Research Personnel;Rest;Role;Sampling;Scanning;Scientist;Signal Transduction;Speed;System;technique development;Techniques;Testing;Time;tool;Training;Travel;ultrasound;Vascular System;Venous

PROJECT_TITLE: Clinically feasible functional MRI providing independent assessments of cerebrovascular stiffness and microcirculation in typical aging and Alzheimer's Disease cohorts


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: HADLEY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: Project Narrative  The formation of protein amyloid fibrils is associated with over 30 human diseases, including Alzheimer's, Parkinson's, type II diabetes, and dialysis-related amyloidosis (DRA), but the molecular details of how these amyloids begin to form are not well understood, which limits our ability to treat these diseases. We intend to develop and apply new mass spectrometry based measurement tools that will yield new molecular-level insight into the early stages of amyloid formation by β-2-microglobulin, which is the protein associated with DRA. This new insight combined with new approaches to screen for amyloid inhibitors will allow us to discover potential treatments for DRA.

PI_NAMEs: VACHET, RICHARD W (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Alzheimer's Disease;Amyloid;Amyloid Fibrils;amyloid formation;Amyloid Proteins;Amyloidosis;beta-2 Microglobulin;biophysical techniques;biophysical tools;Computer Models;Dialysis procedure;Disease;Goals;Hemodialysis;Human;human disease;inhibitor;insight;ion mobility;Isomerism;Joints;Label;Mass Spectrum Analysis;Measurement;Methods;Molecular;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;Outcomes Research;Parkinson Disease;Pathway interactions;Patients;protein protein interaction;Proteins;Research;System;Techniques;Therapeutic;therapeutic development;tool;Work

PROJECT_TITLE: Protein Amyloid Formation and Inhibition Studied by Mass Spectrometry

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Infectious Diseases;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Primary Health Care;Sexually Transmitted Infections;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE  Male adolescents have substantial sexual and reproductive health (SRH) needs, including high rates of  sexually transmitted infections, human immunodeficiency virus, cancer prevention, and unintended partner  pregnancies; yet despite clinical guidelines that recommend primary care providers deliver SRH care to all  male adolescents, very few males receive any singular SRH service. Computer- and clinic-based strategies  have potential to address this gap, but to date, there are not any approaches that promote the recommended  SRH care package for diverse groups of males presenting to care. This project will adapt Health-E You/Salud  iTu, a pre-visit, individually tailored, web-based mobile app that improved female adolescents’ contraceptive  knowledge and contraceptive care receipt, for use with diverse male adolescents; and will examine its  acceptability, usability, and satisfaction among male adolescents and providers; and its efficacy on improving  male adolescents’ knowledge, self-efficacy, beliefs, and behaviors about SRH care after the visit and method  use 2 months later.

PI_NAMEs: MARCELL, ARIK V (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Address;Adolescent;adolescent patient;Age;Area;arm;assigned female at birth;Behavior;Behavioral Model;Belief;Black race;cancer prevention;Caring;Cities;Clinic;Clinic Visits;Clinical;Cluster randomized trial;community partners;Computers;condoms;Contraceptive Agents;Contraceptive Usage;Counseling;Decision Making;design;diversity and inclusion;efficacy testing;Enrollment;Ensure;ethnic minority;Ethnic Origin;evidence base;Family Planning;Female;Female Adolescents;follow-up;Funding;Gender Identity;Grant;Guidelines;Health;Health Promotion;Healthcare;HIV;improved;improved outcome;Individual;Infertility;Infrastructure;Intervention;iterative design;Knowledge;Language;Latino;Life;male;Male Adolescents;Malignant Neoplasms;men who have sex with men;men's group;Methods;mobile application;Mobile Health Application;neglect;Online Systems;Outcome;Population;pre-exposure prophylaxis;Preconception Care;Pregnancy;pregnancy prevention;Preventive care;Primary Care;primary care provider;Privacy;Process;Provider;provider-level barriers;Race;racial minority;Recommendation;reproductive;Reproductive Health Services;Risk Behaviors;satisfaction;school based health center;Schools;Self Efficacy;sex;Sex Behavior;Sex Orientation;sexual and reproductive health;Sexual Development;sexual minority male;sexual relationship;sexually active;Sexually Transmitted Diseases;STI prevention;Technology;Teenagers;Testing;Time;tool;treatment as usual;unintended pregnancy;usability;Visit;Voice;women patients;women's prevention;Work;Youth

PROJECT_TITLE: Health?E You/Salud iTu: Pre-visit mobile health app for male adolescents to promote adolescent?centered sexual & reproductive healthcare receipt

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative While Alzheimer’s Disease (AD) is the leading cause of dementia, affecting over 26 million people worldwide, treatment options have been limited due to the unclear mechanism of disease. The proposed research will use genomic data to identify which genetic variants and genes influence AD risk. The results of this study will increase our mechanistic understanding of AD and reveal new genes for further research and drug develop- ment.

PI_NAMEs: BOND, MARIELLE LOUISE (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Affect;Alleles;Alzheimer's Disease;Alzheimer's disease risk;Astrocytes;ATAC-seq;Automobile Driving;Autopsy;Binding;Biological;Biological Assay;brain cell;brain tissue;causal variant;Cell Line;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR interference;CRISPR/Cas technology;Data Set;Dementia;design;Development;Disease;drug development;Enhancers;Etiology;Exhibits;experimental study;falls;Future;Gene Expression Regulation;gene product;Genes;Genetic;Genetic Transcription;genetic variant;Genome;genome wide association study;genomic data;Genomic Segment;Genomics;Goals;Hi-C;Human;human induced pluripotent stem cells;Inherited;Link;Linkage Disequilibrium;Maps;Methods;Microglia;Modeling;Molecular;multiple omics;Neurodegenerative Disorders;Neurons;Nucleic Acid Regulatory Sequences;Persons;Phenotype;Play;pluripotent stem cell differentiation;promoter;Protocols documentation;Regulatory Element;Reporter;Research;research and development;response;Rest;Risk;risk variant;Specificity;Stimulus;targeted treatment;Techniques;Technology;Therapeutic;therapeutic candidate;therapeutic development;tool;transcription factor;transcriptome sequencing;Untranslated RNA;Validation;Variant;Work

PROJECT_TITLE: Cell-type Specific Interrogation of Variant Function in Alzheimer's Disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Mitochondrial reactive oxygen species (ROS) are strongly implicated in the pathogenesis of Alzheimer's disease (AD) and other aging-related dementias. Mitochondria produce ROS from numerous sites, but the exact roles of individual sites of ROS production in disease-related processes require investigation. The proposed study will determine the roles of mitochondrial complex III-derived ROS in neural signaling, neuroinflammation, and proteinopathy and may reveal complex III as a novel therapeutic target for AD and related dementias.

PI_NAMEs: BARNETT, DANIEL MARTIN (contact)

PROJECT_TERMS: Address;Affect;Aging;aging related;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Animal Model;Astrocytes;beta amyloid pathology;Binding Sites;Cell Respiration;cell type;Cells;Complex;Cysteine;Cytosol;Data;Data Set;Dementia;Development;Disease;disease model;effective therapy;Electron Transport Complex III;Electrons;enhancing factor;Frontotemporal Dementia;Gene Expression;Generations;Genetic;genetic manipulation;Human;human induced pluripotent stem cells;Hydrogen Peroxide;Individual;innovation;Interleukin-1;Interleukin-6;Investigation;Link;Mediating;Methods;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;mouse model;Mus;mutant;Nervous System Disorder;neural;Neuroimmune;neuroinflammation;Neuronal Dysfunction;Neurons;neuropathology;neurotransmission;new therapeutic target;novel;Outcome;oxidation;Oxidation-Reduction;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Pattern;pharmacologic;Positioning Attribute;prevent;Process;Production;Proteins;Proteomics;ratiometric;Reactive Inhibition;Reactive Oxygen Species;Respiration;Respiratory Chain;Role;sensor;Signal Pathway;Signal Transduction;Site;small molecule;Source;spatiotemporal;STAT3 gene;Stimulus;Synapses;targeted treatment;tau mutation;tau Proteins;Tauopathies;Testing;Therapeutic Intervention;tool;Work

PROJECT_TITLE: Mitochondrial complex III-derived ROS in astrocytic signaling and Alzheimer's disease-related pathogenesis


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative A small fraction of Postdoctoral Fellows conducting research in the life sciences come from groups that are traditionally underrepresented in the STEM fields. An even smaller fraction of these individuals advance to become faculty and principal investigators of NIH research grants. Through a partnership of Atlanta institutions of higher education, Spelman, Morehouse, and Clark Atlanta, we have a unique opportunity to help address these problems and enhance inclusive excellence by providing Postdoctoral Fellows with a traditional research-intensive experience coupled with mentored teaching activities at these Minority Serving Institutions in the Atlanta metropolitan area.

PI_NAMEs: BROWN, LOU ANN S (contact);MCCARTY, NAEL A

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Academia;Achievement;Biomedical Research;career;career development;college;course module;Credentialing;Education;Educational process of instructing;Environment;evidence base;experience;Exposure to;Extramural Activities;Faculty;Fellowship;Funding;Goals;graduate school;Historically Black Colleges and Universities;Institution;laboratory module;leadership development;Life;Mentors;Minority-Serving Institution;Morehouse School of Medicine;Positioning Attribute;Postdoctoral Fellow;programs;Qualifying;Recording of previous events;recruit;Research;research and development;Research Project Grants;role model;Schools;Science;Scientist;STEM student;success;teacher;tenure track;Training;Training and Infrastructure;Training Programs;undergraduate student;Underrepresented Populations;Universities;Woman;Women's Group

PROJECT_TITLE: IRACDA Fellowships in Research and Science Training (FIRST)

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Bioengineering;Cancer;Cervical Cancer;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Prevention;Primary Health Care;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative New technologies, including screening tests and vaccines against human papillomavirus (HPV), a sexually- transmitted virus known to cause cervical cancer, are dramatically changing the landscape of cervical cancer control in the US and worldwide. In order to address important evidence gaps, our CISNET-Cervical working group – consisting of five teams who have been at the forefront of modeling cervical cancer prevention over the last decade – will continue this comparative modeling collaboration to evaluate the harms, benefits, and cost-effectiveness of screening and vaccination strategies, and disseminate findings to inform health policies and decisions.

PI_NAMEs: BARNABAS, RUANNE VANESSA;CANFELL, KAREN ;DE KOK, INGE MCM;KIM, JANE JOOYUN (contact);KULASINGAM, SHALINI L.

PROGRAM_OFFICER_NAME: TATALOVICH, ZARIA

PROJECT_TERMS: Address;Adolescent;Australia;base;Cancer Burden;Cancer Control;cancer health disparity;Cancer Intervention and Surveillance Modeling Network;CD4 Lymphocyte Count;Cervical;cervical cancer prevention;Cervical Cancer Screening;cervical carcinogenesis;Clinical Data;Clinical Research;Clinical Trials;co-infection;cohort;Collaborations;comparative;Comparative Carcinogenesis;comparative effectiveness;cost;cost effective;cost effectiveness;Cost Effectiveness Analysis;Country;Data;Decision Making;Development;Disease;Disease Outcome;Disparity;disparity reduction;Effectiveness;effectiveness evaluation;Ensure;Equity;Evaluation;evidence base;Guidelines;Health;Health Benefit;Health Policy;HIV;HPV screening;Human Papilloma Virus Vaccination;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;improved;Infection;Information Dissemination;innovation;Kenya;Knowledge;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;mathematical model;Modeling;Netherlands;New Mexico;new technology;North Dakota;Outcome;Policies;Policy Maker;Population;Populations at Risk;Preventative vaccination;Prevention strategy;Process;Productivity;programs;Public Health;Reporting;Research Personnel;Risk;Route;scale up;screening;screening guidelines;Series;sexually transmitted virus;South Africa;Technology;Testing;Time;tool;Uganda;United States;Update;Vaccinated;Vaccination;vaccination strategy;Vaccines;Woman;working group

PROJECT_TITLE: Comparative Modeling to Inform Cervical Cancer Control Policies