ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Infertility affects nearly 13% of reproductive-age couples, yet the mechanistic basis of infertility remains unclear, hindering targeted therapies. The Massachusetts General Hospital Harvard Center for Reproductive Medicine will perform cutting edge genomic, phenomic, and transcriptomic studies in humans with both rare and common forms of infertility to identify causal biologic drivers and pathways that will inform clinical care and treatment of infertility and improve overall health. The Center will serve as a vibrant hub for training future reproductive biologists and will provide outreach and community engagement with patients, families, and clinicians to reduce the physical and psychological burden of infertility.

PI_NAMEs: SEMINARA, STEPHANIE BETH (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Acceleration;Address;Affect;Age;Architecture;biobank;Biological;Biological Factors;Biological Process;Boston;Brain;Center for Translational Science Activities;Child;Clinical;clinical care;clinical investigation;Clinical Research;clinical translation;Clinical Treatment;cohort;Collection;Communication;Communities;community engagement;Computational Biology;computerized tools;cost;Counseling;Couples;Creativeness;Data Analytics;Denmark;design;Diagnosis;Disease;DNA;Education and Outreach;Endocrinology;Estonia;Ethnic Population;evidence base;Faculty;Family;Fertility;Financial Hardship;Finland;flexibility;Fostering;functional genomics;Future;gene discovery;gene function;General Hospitals;Genes;Genetic;genetic architecture;Genetic Engineering;genome editing;genome wide association study;genomic variation;Genomics;Genotype;GNRH1 gene;Goals;gonad development;Gonadal structure;Group Meetings;Gynecology;Health;Hospitals;Human;Human Development;human disease;human induced pluripotent stem cells;Hypogonadism;improved;Individual;Infertility;infertility treatment;Information Dissemination;innovation;Institution;Interdisciplinary Study;International;Investigation;Investments;Knowledge;Lead;Leadership;lens;Link;literacy;Longitudinal Studies;Massachusetts;member;Mendelian randomization;Mentors;Mentorship;Methodology;Methods;Morbidity - disease rate;mortality;multi-ethnic;Mutation;National Institute of Child Health and Human Development;neuron development;next generation;next generation sequencing;Operative Surgical Procedures;outreach;Parents;Pathway interactions;Patients;Pediatrics;Penetrance;phenome;phenomics;Phenotype;Physiological;Population;population based;Population Genetics;Positioning Attribute;Prevention;Provider;psychologic;Public Health;Rare Diseases;Reproduction;reproductive;Reproductive Biology;Reproductive Health;Reproductive Medicine;Research;Research Personnel;Research Project Grants;Resources;Role;Sampling;Scientist;Services;sex;skills;Strategic vision;targeted treatment;Technology;Therapeutic;Thinking;Training;trait;transcriptomics;Translational Research;translational scientist;Urology;Validation;web site;Work


ADMINISTERING_IC: AA

ARRA_FUNDED: N

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

ORG_CITY: BINGHAMTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

ORG_STATE: NY

PHR: PROJECT NARRATIVE Alcohol use during pregnancy is very common and can result in the development of Fetal Alcohol Spectrum Disorder in offspring, which is often associated with impaired social function. The proposed experiments are designed to explore possible mechanisms that are disrupted by prenatal alcohol exposure and contribute to deficits in social behavior. Identification of mechanisms that are dysregulated by prenatal alcohol exposure may help inform target treatment development for individuals with prenatal alcohol exposure induced social impairments.

PI_NAMEs: SCHATZ, KELCIE  (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: Address;Adult;Adult Children;Affect;Air;Alcohol consumption;alcohol exposure;Amygdaloid structure;antagonist;Anxiety;Anxiety Disorders;anxiety-like behavior;anxiety-related behavior;Behavior;Behavioral;Brain region;career;cell type;Cells;Central Medial Thalamic Nucleus;Communication;Corticotropin-Releasing Hormone;design;Development;Electrophysiology (science);emotion regulation;Enterobacteria phage P1 Cre recombinase;Experimental Designs;experimental study;Female;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fetal Development;FOS gene;Future;gamma-Aminobutyric Acid;Genetic;Glutamates;Goals;Impairment;in utero;in vivo;Individual;Investigation;Knowledge;Learning;life span;male;Measures;Medial;Mediating;Mentors;midbrain central gray substance;Mus;neural circuit;neuroadaptation;neurobiological mechanism;Neurobiology;neurogenesis;neuromechanism;neuronal excitability;Neurons;neurotransmission;novel;offspring;patch clamp;Pattern;Persons;Physiology;Pre-Clinical Model;Prefrontal Cortex;Pregnancy;prenatal experience;Rattus;receptor;Regulation;Reporting;Research Design;Research Personnel;response;Role;Science;Scientist;skills;social;social anxiety;Social Behavior;social defeat;Social Functioning;social influence;Social Interaction;Stains;Synapses;synaptic function;System;Techniques;Testing;therapy development;Time;Training;transmission process;United States

PROJECT_TITLE: Impact of Prenatal Alcohol Exposure on CRF1R Mediated Neural Mechanisms and Social Behavior


ADMINISTERING_IC: HD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

PROJECT_TERMS: Architecture;Award;clinical care;Collaborations;Communication;Communities;Development;diagnostic tool;Education and Outreach;Ensure;Family;Focus Groups;General Hospitals;Genetic;genetic architecture;Goals;Grant;Hospitals;Human Resources;Individual;Infertility;Information Dissemination;Information Technology;Infrastructure;Institution;Massachusetts;meetings;novel;Nuclear;Participant;Patient Care;Patient Recruitments;Patients;phenomics;Phenotype;Positioning Attribute;Prevention strategy;Productivity;professor;Protocols documentation;psychologic;Public Health Schools;Reporting;Reproductive Biology;Reproductive Medicine;Research;Research Personnel;Research Project Grants;Series;Services;social media;symposium;trait;Travel;Visit;Woman;Work

PROJECT_TITLE: Core A - Administrative


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: ATLANTA

ORG_DEPT: PATHOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Transfusion medicine represents an important specialty that provides blood components and cell therapies for clinical use. Future improvements and developments in this field will lead to safer and more effective therapies. This training program will produce many of the future leaders who will spearhead these advances in transfusion and related therapies.

PI_NAMEs: ROBACK, JOHN D (contact);STOWELL, SEAN R

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Grant;Training;transfusion medicine

PROJECT_TITLE: Training Grant in Transfusion Medicine

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Mental Illness;Pediatric

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: We urgently need to sustain and grow training opportunities to address the critical shortage of investigators who are prepared to transform child mental health with our growing understanding of neurobiology. The Translational Research Training in Child Psychiatry Program at Columbia University/New York State Psychiatric Institute is designed to address this shortage by increasing the cadre of clinician-scientists and clinically-informed neuroscientists trained to undertake translational research in child and adolescent mental health.

PI_NAMEs: FITZGERALD, KATE DIMOND;MARSH, RACHEL ;VEENSTRA-VANDERWEELE, JEREMY  (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Child Psychiatry;Research Training;Translational Research


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Contraception/Reproduction;Genetics;Human Genome;Infertility;Neurosciences;Prevention;Rare Diseases;Women's Health Research

PROJECT_TERMS: Address;Affect;Alternative Splicing;biobank;Biological;Biological Models;causal variant;Clinical;clinical care;Clinical Investigator;Clustered Regularly Interspaced Short Palindromic Repeats;Code;cohort;Couples;CRISPR/Cas technology;Data;Development;Diagnosis;Diagnostic;diagnostic tool;Disease;Drosophila genus;Engineering;Evaluation;exome;experimental study;Fertility;Gene Expression;General Hospitals;Genes;genetic architecture;Genetic Counseling;Genetic Heterogeneity;Genetic Risk;genetic variant;Genetic Variation;genome sequencing;Genomics;Genotype;GNRH1 gene;Goals;Gynecologic;Health;Hospitals;Human;Human Genetics;human genomics;Hypogonadism;Hypothalamic structure;Idiopathic Hypogonadotropic Hypogonadism;Individual;Induced pluripotent stem cell derived neurons;Infertility;Infertility study;insertion/deletion mutation;Kallmann Syndrome;KISS1 gene;knock-down;lens;Massachusetts;Measures;Medical Genetics;Methodology;migration;Modeling;Molecular;Morphology;Mutation;National Institute of Child Health and Human Development;Neurons;novel;novel diagnostics;novel therapeutics;Ovarian;Ovary;overexpression;Pathogenicity;Pathway interactions;Patients;Pattern;Penetrance;phenomics;Phenotype;Physiologic pulse;Pituitary Gland;Population;precision medicine;premature;Prevention strategy;primary ovarian insufficiency;Puberty;Rare Diseases;Regulatory Pathway;Relative Risks;reproductive;reproductive function;Reproductive Health;reproductive hormone;Reproductive Medicine;Research Personnel;risk prediction;risk variant;RNA Interference;Running;Saudi Arabia;Services;Single Nucleotide Polymorphism;Strategic Planning;targeted treatment;Techniques;Technology;transcriptome;transcriptomics;treatment strategy;Universities;Untranslated RNA;Utah;Variant;variant detection;whole genome

PROJECT_TITLE: Project 1 - Deciphering the Molecular Drivers of Rare Forms of Human Infertility Using Integrative Genomic, Cellular, and Phenomic Approaches


ADMINISTERING_IC: NS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: JMJD3 (KDM6B) – a gene that produces a protein that modifies the structure and function of the human genome – has roles central to both normal brain development and a wide range of neurological diseases. Understanding how JMJD3 functions in brain development will provide important basic insights into major neurodevelopmental disorders and how the adult brain can continue to generate new neurons throughout life from a population of neural stem cells. Furthermore, results obtained will help inform the development and use of JMJD3 inhibitors, which have shown promise as a drug treatment for pediatric brain tumors.

PI_NAMEs: LIM, DANIEL A (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Address;Adult;Architecture;Area;autism spectrum disorder;autosome;Behavior;Behavioral;Biological Models;Brain;cancer therapy;Childhood Brain Neoplasm;Chromatin;chromatin modification;Cognitive deficits;Complex;CRISPR/Cas technology;Cytoplasmic Granules;Data;dentate gyrus;Development;Disease;drug development;emotional behavior;Engineering;Enhancers;Epigenetic Process;experimental study;Gene Dosage;Gene Expression;gene repression;Genes;Genetic;Genome;Genomic Segment;Genomics;Goals;Heterozygote;Higher Order Chromatin Structure;Hippocampus;histone demethylase;Histones;Human;human disease;Human Genome;Impaired cognition;Impairment;in vivo;inhibitor;innovation;insight;Intellectual functioning disability;Knowledge;Learning;Life;Lysine;Malignant Neoplasms;Maps;Memory;Methods;Methylation;Molecular;mouse development;mouse model;Mus;Mutant Strains Mice;Mutation;nerve stem cell;Nervous System Disorder;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;Neurons;novel;Nuclear;Outcome;Pharmacotherapy;Phenotype;Population;postnatal;Process;Production;promoter;Proteins;recruit;Regulator Genes;Research;Role;single-cell RNA sequencing;stem cell population;Structure;Testing;Tissues;Transcriptional Activation

PROJECT_TITLE: Understanding the neurodevelopmental role and mechanism of histone demethylase JMJD3

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lyme Disease;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative: In this R01 grant application, we will study immunometabolism in the context of tick-borne diseases. Tick-borne illnesses are the most prevalent arthropod-borne maladies in the United States and Europe and affect public and veterinary health. This R01 project will provide a novel paradigm to arthropod immunology and lead to remarkable basic science knowledge for vector-borne diseases.

PI_NAMEs: PEDRA, JOAO  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Address;Affect;Anaplasma phagocytophilum;Anaplasmosis;Applications Grants;Arachnida;Area;Arthropod Vectors;arthropod-borne;Arthropods;Babesia microti;Babesiosis;Basic Science;Biochemical;Bioenergetics;Bioinformatics;Biology;Black-legged Tick;Borrelia burgdorferi;Borrelia miyamotoi;Categories;Cell Wall;Cells;Cholesterol;Communicable Diseases;Communities;cost effective;Coupling;Enabling Factors;Ensure;Enzymes;Europe;FADD protein;fitness;flexibility;Funding;Genes;Genome;Gram-Negative Bacteria;granulocyte;Health;hematophagy;Hemocytes;Human;Immune;Immune response;Immune signaling;Immune system;Immunity;Immunobiology;immunodeficiency;Immunologic Stimulation;Immunology;infancy;Infection;Insecta;interest;Ixodes;Knowledge;Laboratories;Life;Life Cycle Stages;Life Style;Ligands;Lipids;Lipopolysaccharides;Longevity;Lyme Disease;Lysine;Mammals;member;Membrane;Metabolic;Metabolism;Microbe;microbial;microbial colonization;Molecular;Monoclonal Antibodies;novel;Nuclear;Order Spirochaetales;Organism;pathogen;Pathway interactions;Pattern;Peer Review;Peptidoglycan;peptidoglycan recognition protein;Phylogeny;Physiology;Population;Powassan virus;Process;programs;Proteins;Public Health;Publications;receptor;Resources;Rickettsia;Role;scaffold;screening;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Textbooks;Tick-Borne Diseases;Tick-Borne Encephalitis;Tick-Borne Relapsing Fever;Ticks;transmission process;Tumor Necrosis Factor Receptor;ubiquitin-protein ligase;United States;vector;vector tick;Vector-transmitted infectious disease;x-linked inhibitor of apoptosis protein

PROJECT_TITLE: The Tick Immune Response During Microbial Infection

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Project Narrative: Superoxide is a threat to all forms of life and its toxicity is harnessed by the immune system to combat infection. Superoxide dismutases are metal utilizing enzymes that enable us and invading microbes to cope with superoxide, yet we do not know the molecular or environmental factors that dictate the metal utilized by these enzymes. The proposed studies will address this unanswered question, providing insight into how both humans and invading pathogens overcome the universal threat of superoxide.

PI_NAMEs: KEHL-FIE, THOMAS EVERETT (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Amino Acid Sequence;Anaerobic Bacteria;Archaea;Bacteria;Bacteroides thetaiotaomicron;Binding;Biochemical;Biological Assay;Catalysis;Chemistry;cofactor;combat;coping;cystic fibrosis patients;Data Set;Development;Drug Metabolic Detoxication;Electron Spin Resonance Spectroscopy;Environment;Environmental Risk Factor;Enzymes;Eukaryota;Evolution;experimental study;Exposure to;Family;Family member;Genus staphylococcus;Goals;Growth;Human;Immune;Immune system;improved;In Vitro;Individual;Infection;insight;Invaded;Investigation;Iron;Leukocyte L1 Antigen Complex;Life;Manganese;member;Metagenomics;metalloenzyme;Metalloproteins;Metals;Microbe;Molecular;mutant;Organism;Oxidative Stress;Oxygen;pathogen;pathogenic microbe;Physiological;preference;Property;Protein Family;Proteins;Publishing;Reporting;Resistance;Respiratory Burst;Role;Shapes;SOD2 gene;soft drink;Staphylococcus aureus;Starvation;Streptococcus pneumoniae;Superoxide Dismutase;Superoxides;Testing;Time;tool;Toxic effect;Variant;Work

PROJECT_TITLE: Leveraging host-imposed metal starvation to elucidate the molecular and environmental factors that dictate metal utilization by the iron/manganese superoxide dismutase superfamily

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative: In this project, we will determine the role of MOF and Histone 4 Lys16 acetylation in epidermaldevelopment. We will elucidate how MOF and the epigenetic mark control the expression of genes important for cilium morphogenesis and mitochondria. Knowledge gained from the proposed studies will help to establish a new transcriptional and epigenetic mechanism during mammalian skin development.

PI_NAMEs: YI, RUI  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Acetylation;Acetyltransferase;Adhesions;Affect;Aging;Binding;Binding Proteins;Biochemical;Biological Models;Biology;biophysical analysis;Cell Lineage;Cell Physiology;Cells;Chromatin;Cilia;cilium biogenesis;Code;Collaborations;Computational Biology;conditional knockout;Data;Defect;Development;Disease;Dosage Compensation (Genetics);Drosophila genus;Drosophila melanogaster;Embryo;embryonic stem cell;Enhancers;Enzymes;Epigenetic Process;epigenetic regulation;Epithelial Cells;Epithelium;Family;fly;Gene Dosage;Gene Expression;Genes;Genetic;Genetic study;Genetic Transcription;genomic tools;Genomics;Goals;HDAC1 gene;Histologic;Histone Code;Histone Deacetylase;Histone H4;histone modification;Histones;Homeostasis;Human;Immunofluorescence Immunologic;insight;keratinocyte;Knockout Mice;Knowledge;liver development;Lysine;male;Mammals;Mediating;Mitochondria;mitochondrial metabolism;Molecular;Morphogenesis;mouse genetics;mouse model;Mus;novel;Nucleosomes;Organelles;Pericytes;Play;promoter;Regulation;Resolution;Role;Saccharomycetales;sex;Signal Transduction;single cell analysis;Skin;skin organogenesis;spatiotemporal;Structure;Tail;Tissues;tool;transcription factor;Transcriptional Activation;Transcriptional Regulation;transcriptome;transcriptomics;X Chromosome

PROJECT_TITLE: Investigate MOF regulated epigenetic mechanisms of skin development

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Relevance By elucidating the circuit mechanisms at cellular resolution, it will be possible to construct underlying Pf quantitatively determine action initiation, which is impaired in major neurological and psychiatric disorders. Results from the proposed studies can shed light on the major clinical symptoms of disorders implicating this circuit and lead to novel treatment strategies.

PI_NAMEs: YIN, HENRY  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: 3-Dimensional;Architecture;Area;Arousal;Attention;attentional control;Basal Ganglia;Behavior;Behavior monitoring;Behavioral;Behavioral Assay;Bypass;Calcium;Cell Nucleus;cell type;Cells;Clinical;Corpus striatum structure;Development;Disease;Dissection;Dopamine;Electrophysiology (science);environmental change;experimental study;flexibility;Ganglia;Generations;Image;Impairment;in vivo;Individual;Intralaminar Nuclear Group;Learning;Lesion;Mediating;Mental disorders;Midbrain structure;Modernization;Motion;Movement;Nervous System Disorder;neural;neural circuit;Neurons;novel;Operant Conditioning;optogenetics;Output;Parafascicular Nucleus;Pathway interactions;Photons;Play;Population;Population Projection;Positioning Attribute;Primates;Process;Resolution;Role;Sensory impairment;Sensory Neglects;Structure;Structure of subthalamic nucleus;superior colliculus Corpora quadrigemina;Symptoms;System;Thalamic structure;tool;treatment strategy;wireless;Work

PROJECT_TITLE: The Role of Parafascicular Thalamic Circuits in Action Generation

STUDY_SECTION: SMI

STUDY_SECTION_NAME: Sensorimotor Integration Study Section[SMI]


PI_NAMEs: LINDGREN, CECILIA M. (contact)

PROJECT_TERMS: Acceleration;Address;Affect;Alleles;Assisted Reproductive Technology;biobank;Bioinformatics;Biological;Biological Assay;Biological Process;Biology;Brain;Cell model;cell type;Chromosome Mapping;Collaborations;Complex;computerized tools;cost;Couples;Data;data access;Development;Endocrine System Diseases;Evaluation;Female infertility;Fertility;Gene Expression;General Hospitals;Genes;Genetic;genetic analysis;genetic architecture;genetic association;genetic linkage;Genetic study;genetic variant;Genetic Variation;genome wide association study;genome-wide;Genomics;GNRH1 gene;Gonadal Steroid Hormones;Health;Hormonal;Human;Human Genetics;in silico;Individual;Infertility;Infertility study;infertility treatment;Investigation;Knowledge;Male Infertility;Maps;Massachusetts;Mendelian randomization;Meta-Analysis;Methods;Modeling;Molecular;Morbidity - disease rate;Neurons;novel;olfactory bulb;Overlapping Genes;Pathway Analysis;Pathway interactions;Pattern;phenome;phenomics;Phenotype;Pituitary Gland;pleiotropism;Population;protein protein interaction;Protocols documentation;Puberty;Rare Diseases;reproductive;Reproductive Health;Reproductive Medicine;Risk;Risk Factors;Sampling;Series;Structure;Techniques;Technology;trait;Validation;Variant;Visualization

PROJECT_TITLE: Project 2 - Deciphering the Molecular Drivers of Common Forms of Human Infertility Using Integrative Genomic, Cellular, and Phenomic Approaches


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative Bacterial intercellular communication is required to induce adaptive traits and community behaviors such as competence, biofilm formation, and virulence gene expression. A range of Gram positive bacteria, including highly pathogenic species, use small cyclic peptides to signal to nearby bacterial cells. We will investigate newly uncovered mechanics of cyclic peptide maturation in Staphylococcus aureus with goals of improving our understanding of bacterial cell-cell communication and promoting development of novel therapeutics.

PI_NAMEs: ALONZO, FRANCIS  (contact)

PROJECT_TERMS: Active Sites;Affect;Amino Acid Sequence;Attenuated;attenuation;Behavior;Biochemical;Biochemistry;Cell Communication;Cell membrane;Cells;Characteristics;Communicable Diseases;Communities;Competence;Congenic Strain;Cyclic Peptides;Cysteine;Data;Defect;Development;Disease;Elements;Enterococcus;Event;Family;Gene Expression;Genes;genetic approach;Genetic Screening;Genus staphylococcus;Goals;Gram-Positive Bacteria;Grant;Health;improved;Infection;Infectious Skin Diseases;insight;intercellular communication;Knowledge;Link;Listeria;Lung infections;Mass Spectrum Analysis;Mechanics;Mediator;Membrane;Membrane Proteins;Metal Binding Site;Metalloproteases;Microbe;Microbial Biofilms;Modeling;Mus;mutant;Mutation;N-terminal;novel therapeutics;Open Reading Frames;pathogen;Pathogenesis;Pathogenicity;Peptide Biosynthesis;Peptide Hydrolases;Peptide Leader Sequences;Peptide Signal Sequences;Peptides;Periodicity;Pheromone;Process;Production;protein aminoacid sequence;Protein Precursors;Proteins;quorum sensing;Recombinants;Role;Signal Induction;Signal Transduction;Specificity;Staphylococcus aureus;System;Testing;trait;Variant;Virulence;Virulence Factors;virulence gene

PROJECT_TITLE: Intercellular Communication and Pheromone Maturation in Gram-Positive Bacteria.


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: CANANDAIGUA

ORG_NAME: VETERANS AFFAIRS, UNITED STATES DEPARTMENT OF

PHR: According to Clinical Practice Guidelines, psychosocial interventions for pain are recommended as first-line treatments to manage pain, yet barriers to care, including patient beliefs, interfere with initiation of such treatments. The proposed study uses a cognitive-behavioral intervention to target beliefs to increase the initiation and engagement in psychosocial interventions for pain among Veterans using prescription opioids. This study will test the effects of this evidence-based intervention on increasing treatment initiation of and retention to psychosocial interventions for pain and the subsequent effects on pain and substance use outcomes.

PI_NAMEs: ASHRAFIOUN, LISHAM  (contact)

PROJECT_TERMS: active method;addiction;Address;Affect;Aftercare;alcohol use disorder;Area;barrier to care;Belief;Caring;chronic pain;chronic pain management;Clinical Practice Guideline;Cognitive Therapy;comparison control;COVID-19 impact;Dissemination and Implementation;Dose;Education;evidence base;Evidence based intervention;Feeling suicidal;follow-up;Functional impairment;future implementation;Goals;Growth;high risk;implementation research;improved;Individual;ineffective therapies;innovation;Intervention;Investigation;Mental Health;Methodology;mindfulness-based stress reduction;Modality;Morbidity - disease rate;mortality;Nonpharmacologic Therapy;Opioid;Opioid Analgesics;opioid misuse;opioid tapering;opioid therapy;opioid use;opioid use disorder;Outcome;Overdose;Pain;Pain management;pain outcome;pain reduction;pain relief;Participant;patient population;Patient-Centered Care;Patients;Physical Function;Policies;Population;Post-Traumatic Stress Disorders;Premature Mortality;prescription opioid;prevent;psychiatric comorbidity;psychologic;psychosocial;Public Health;Randomized;Recommendation;Reporting;Research;Resistance;Risk;Safety;Services;Severities;social stigma;Stigmatization;substance use;Suicide;symposium;Symptoms;telehealth;Testing;Thinking;Training;Veterans;Work

PROJECT_TITLE: Telehealth CBT to increase engagement in pain treatment among Veterans using prescription opioids

STUDY_SECTION_NAME: Special Emphasis Panel[HSR9]


ORG_CITY: SEATTLE

ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

ORG_STATE: WA

PHR: Women Veterans using VA health care are increasingly diverse in terms of race/ethnicity, sexual orientation, and gender identity, and have complex medical and mental health care needs, and a high prevalence of sexual trauma. These characteristics and experiences shape their experiences of VA health care and their outcomes. We propose to develop the first patient-reported experiences measure for VA women’s health care (WV_PREM) to inform patient-centered quality improvement. We will use semi-structured interviews, Veteran focus groups, and psychometric validation in a cohort of women Veteran VA health care users. Our innovative approach will intentionally incorporate the voices and experiences of those with marginalized identities. We will work with our operational partners to implement WV_PREM for surveillance of VA health care quality and equity.

PI_NAMEs: KATON, JODIE  (contact)

PROJECT_TERMS: Acceleration;Address;Area;biological sex;Black race;care coordination;care outcomes;Caring;Characteristics;Client satisfaction;Clinic;Clinical;cognitive interview;cohort;Communities;Complex;Consensus;demographics;design;Development;Dimensions;Discrimination;effectiveness testing;Ensure;Equity;Ethnic Origin;experience;Face;Feedback;Focus Groups;Future;Gender;Gender Identity;gender minority;harassment;health care quality;Health Care Surveys;health disparity;Health Personnel;Healthcare;Healthcare Systems;High Prevalence;implementation trial;improved;Individual;Inequity;innovation;Institution;instrument;Interview;Journals;Judgment;Learning;marginalization;Measures;Medical;medical specialties;meetings;Mental Health;Mental Health Services;Methodology;Methods;Military Personnel;Monitor;Outcome;patient expectation;Patient Monitoring;patient oriented;Patient-Centered Care;patient-clinician communication;Patients;Peer Review;perceived discrimination;Performance;Policies;Population;preference;Primary Care;Primary Health Care;Privacy;Process;Process Measure;programs;Provider;Psychometrics;Publications;Quality of Care;Race;racial discrimination;Recording of previous events;Reporting;Reproductive Health;Research;Research Personnel;Review Literature;Role;Safety;Sampling;Series;sex;Sex Orientation;sexual minority;sexual trauma;Shapes;Site;social;Structure;Terminology;Testing;therapy design;Time;tool;Trust;Validation;Variant;Veterans;Voice;Woman;Women's cohort;Women's Health;Work

PROJECT_TITLE: Development and Validation of a Patient Reported Experience Measure for VA Women's Health Care

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


ORG_CITY: MADISON

ORG_NAME: WM S. MIDDLETON MEMORIAL VETERANS HOSP

ORG_STATE: WI

PHR: Nearly 8 in 10 Veterans meet criteria for overweight/obesity. Three evidence-based treatment options are available within VA (behavioral weight management [MOVE!], obesity medications, and bariatric surgery). However, all treatments are significantly underutilized. This study will evaluate the effectiveness of a novel intervention designed to increase obesity treatment initiation and subsequently weight loss within VA. The intervention, Teaching Obesity Treatment Options to Adult Learners (TOTAL), involves an educational video and multiple motivational sessions delivered via telemedicine. If effective, TOTAL could be implemented throughout VA without requiring significant resources and could be integrated into the existing VA behavioral weight management program, MOVE!, which is present at nearly every VA medical center.

PI_NAMEs: FUNK, LUKE M (contact)

PROJECT_TERMS: Address;Adult;Age;Attitude;Awareness;bariatric surgery;barrier to care;Behavior;Behavior Therapy;Behavioral;Body mass index;Body Weight Changes;Body Weight decreased;care recipients;Caring;Clinical;Collaborations;comorbidity;compare effectiveness;Consolidated Framework for Implementation Research;cost;Cost Analysis;Decision Making;Development;Dietary intake;disorder prevention;Drug Prescriptions;Education;Educational process of instructing;effectiveness evaluation;Electronic Health Record;Elements;Evaluation;evidence base;Evidence based treatment;Future;Goals;Health;Health behavior;Health Expenditures;Health Promotion;Health Services Accessibility;Healthcare Systems;Homogeneously Staining Region;Hypertension;implementation cost;Improve Access;improved;innovation;Intervention;Interview;Knowledge;Lead;Malignant Neoplasms;Measures;Medical center;Methodology;Modeling;Motivation;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;obesity risk;obesity treatment;Office Surgery;operation;Outcome;Outcome Assessment;Overweight;Participant;Patients;Pharmaceutical Preparations;pharmacy benefit;Physical activity;pilot test;population based;population health;post intervention;Preparation;primary outcome;programs;Protocols documentation;Provider;Quality of life;Randomized;randomized trial;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Research;Research Personnel;Research Priority;Resources;retention rate;Schedule;secondary outcome;Site;study population;Surveys;symposium;Systems Integration;Technology;telehealth;Telemedicine;Telephone;Testing;therapy design;treatment as usual;Treatment Effectiveness;Veterans;Visit;Weight maintenance regimen;Work

PROJECT_TITLE: Teaching Obesity Treatment Options to Adult Learners (TOTAL): A Multi-site RCT


PI_NAMEs: DWYER, ANDREW ALOIS (contact)

PROJECT_TERMS: Attitude;Awareness;Caring;Cellular Phone;clinical care;clinical practice;Cognitive Science;Collaborations;Communication;Communities;Complex;Computers;Data;design;Education;Education and Outreach;Electronics;empowerment;enhanced care;Ensure;evidence base;Evidence based practice;experience;Family;Fertility;Focus Groups;Fostering;General Hospitals;General Population;Genetic;genetic counselor;genetic information;Genetic Research;Genetic Risk;genetic testing;Genomics;Geography;Goals;Guidelines;Health;health disparity;Health Personnel;Health Professional;Healthcare;human centered design;improved;Individual;Infertility;Infrastructure;Knowledge;Language;Lead;Learning;Link;literacy;Massachusetts;mathematical ability;meetings;Methods;Neurosciences;Online Systems;Participant;patient engagement;patient population;Patients;peer;Peer Review;peer support;person centered;Personal Satisfaction;Physicians;Process;Professional Organizations;programs;Provider;Publications;Quality of life;Rare Diseases;Recording of previous events;Reporting;Reproductive Medicine;Research;Research Activity;Research Priority;Resources;Risk;Specificity;Structure;Tablets;Test Result;Therapeutic;Thinking;tool;Translating;user centered design;user-friendly;virtual patient;Visual;web platform;web site;Work

PROJECT_TITLE: Core C - Education/Outreach


ORG_CITY: WEST HAVEN

ORG_NAME: VA CONNECTICUT HEALTHCARE SYSTEM

ORG_STATE: CT

PHR: Veterans face serious risks when taking long-term opioid therapy for chronic pain and there is evidence that this treatment approach is not effective. The Department of Veterans Affairs (VA) and other agencies have recommended carefully reducing or discontinuing long-term opioid therapy when benefits of therapy no longer outweigh risks. However, reducing long-term opioid therapy can present risks to patients including withdrawal symptoms, worsened mental health conditions, substance use, opioid overdose, and death. Early research evidence suggests that some holistic treatments such as yoga, exercise, and chiropractic care can improve pain and facilitate reductions in opioid therapy. In this study, guided by advisory groups made up of VA leaders and Veterans with chronic pain, we will test whether Veterans who have used such holistic treatments tended to have better outcomes when reducing their opioid treatment. Results from this research will be used to suggest changes in how long-term opioid therapy is reduced.

PI_NAMEs: BECKER, WILLIAM C;BLACK, ANNE C. (contact)

PROJECT_TERMS: addiction;Address;Adverse event;adverse outcome;age effect;American;Articulation;Benefits and Risks;Buprenorphine;buprenorphine treatment;Caring;Centers for Disease Control and Prevention (U.S.);Cessation of life;Characteristics;chiropracty;chronic pain;chronic pain management;Clinical;cohort;Combined Modality Therapy;Communities;comorbidity;compare effectiveness;Complementary Health;COVID-19;COVID-19 impact;Data;data warehouse;Deimplementation;design;Dose;Dropout;effective therapy;Effectiveness;effectiveness outcome;Electronic Health Record;Electronics;Emergency department visit;Equilibrium;Ethnic Origin;Evaluation;Evaluation Reports;Event;evidence base;Exercise;experience;Face;Feeling suicidal;Formulation;Funding;Gender;Goals;Guidelines;Health Services;Healthcare Systems;Hospitalization;implementation study;improved;innovation;Institution;Integrative Medicine;Measures;medication safety;Mental disorders;Mental Health;Methodology;Methods;milligram;Modality;Modeling;morphine equivalent;mortality;multidisciplinary;multilevel analysis;multimodality;novel;Opiate Addiction;Opioid;opioid mortality;opioid overdose;opioid tapering;opioid therapy;opioid use;opioid use disorder;Outcome;Overdose;Pain;Pain intensity;Pain management;Patient-Centered Care;Patients;Pattern;Perception;Personal Satisfaction;pharmacy benefit;Pharmacy facility;physical conditioning;Physiological;Practice Management;prescription opioid;Prevention Guidelines;Quasi-experiment;Race;Randomized, Controlled Trials;Recommendation;Recovery;Regimen;Research;Research Design;Retrospective cohort;Retrospective cohort study;Risk;Role;Safety;Sampling;scale up;secondary analysis;Serious Adverse Event;service uptake;service utilization;Services;side effect;Site;sociodemographics;Substance Addiction;substance use;Substance Use Disorder;Suicide attempt;symposium;Testing;Translations;treatment effect;United States Department of Veterans Affairs;uptake;Veterans;Veterans Health Administration;whole health;Withdrawal Symptom;Work;Yoga

PROJECT_TITLE: Role of Non-pharmacological Pain Treatments in Safe and Effective Opioid Tapering in Chronic Pain


PI_NAMEs: TALKOWSKI, MICHAEL E (contact)

PROJECT_TERMS: 3-Dimensional;aggregation database;Alleles;Bayesian Modeling;biobank;Biological Assay;case control;Catalogs;Categories;Cell Line;Cell model;cloud based;Clustered Regularly Interspaced Short Palindromic Repeats;Code;cohort;Collection;Communities;Complex;computerized data processing;computerized tools;Copy Number Polymorphism;Data;Data Analyses;Data Set;de novo mutation;Disease;dosage;Engineering;exome;exome sequencing;Family;Female;Fertilization;follow-up;functional genomics;gene discovery;Gene Expression Profile;Gene Expression Profiling;General Hospitals;Genes;genetic architecture;Genome;genome resource;genome sequencing;genomic data;Genomic medicine;genomic profiling;genomic variation;Genomics;GNRH1 gene;Human;human disease;human induced pluripotent stem cells;Idiopathic Hypogonadotropic Hypogonadism;Individual;Infertility;insertion/deletion mutation;insight;Joints;Kallmann Syndrome;loss of function;loss of function mutation;male;Massachusetts;Methods;Modeling;Molecular;multidisciplinary;Mutation;Neurodevelopmental Disorder;Neurons;novel;Pathogenicity;Pathway interactions;Patients;Phenotype;Point Mutation;Population;prime editing;Process;progenitor;programs;rare variant;Reagent;Reproductive Medicine;Research;Resources;Risk;Sampling;Scoring Method;Series;Services;System;Technology;trait;transcriptome;transcriptome sequencing;transmission process;Untranslated RNA;Variant;variant detection;whole genome

PROJECT_TITLE: Core B - Technical Services


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Pregnancy

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: NARRATIVE At present, methods to predict pregnancy-induced and cytokine-induced changes in transporter-mediated drug disposition are not available. We propose a systems pharmacology approach to address this significant knowledge gap. Such studies are important for rational design of dosing regimens of drugs that maximize efficacy and safety when administered to pregnant women with pro-inflammatory infectious diseases.

PI_NAMEs: LANCHOTE, VERA LUCIA;UNADKAT, JASHVANT D (contact)

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: ABCG2 gene;absorption;Address;Affect;Animals;Avena sativa;Brazil;Cells;Clinical;clinically significant;Collaborations;Communicable Diseases;Confidence Intervals;CYP3A4 gene;Cytochrome P450;cytokine;Data;design;Digoxin;Disease;Dose;drug clearance;drug disposition;Drug Kinetics;Drug Transport;Drug usage;Eligibility Determination;Enterocytes;Enzymes;Epithelial Cells;Estradiol;falls;fexofenadine;Funding;Furosemide;Gestational Age;Goals;Hepatocyte;HIV;Hormones;Human;Human Cell Line;human tissue;In Vitro;in vivo;Indinavir;Individual;Infection;Inflammation;Inflammatory;interest;Interferon Type II;Interleukin-6;Intestines;Kidney;Knowledge;Lamivudine;Liver;Measures;Mediating;Membrane;men;Messenger RNA;Methods;models and simulation;Pharmaceutical Preparations;pharmacokinetic model;Pharmacology;physiologically based pharmacokinetics;Plasma;Population;predictive modeling;Pregnancy;Pregnant Women;Progesterone;Proteins;Proteomics;rational design;Regimen;renal epithelium;Reporting;Request for Applications;rosuvastatin;Safety;System;Tenofovir;Therapeutic;TNF gene;Transfection;Translating;United States National Institutes of Health;Vesicle;Virus Diseases;Woman

PROJECT_TITLE: A Systems Pharmacology approach to predict the effects of pregnancy and infectious diseases on transporter-mediated drug disposition

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


NIH_SPENDING_CATS: Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: DERMATOLOGY

PHR: Project Narrative Differentiated cells of the epidermis form the essential barrier of the skin. This work examines the role of differentiated cells of the skin in controlling their stem cell parents. Understanding the regulation of skin stem cell behavior is essential to allow us to manipulate these cells for regenerative/wound-healing therapies and/or for the treatment of diseases that result from stem cell dysregulation.

PI_NAMEs: LECHLER, TERRY H (contact)

PROJECT_TERMS: Ablation;Adherens Junction;Architecture;Automobile Driving;Back;Basement membrane;Behavior;Cell Adhesion;cell behavior;Cell Count;Cell Differentiation process;cell type;Cells;Chemicals;Collaborations;Communication;Coupling;Data;Daughter;daughter cell;Dermis;Development;Disease;Embryonic Development;embryonic stem cell;Ensure;Environmental Risk Factor;epidermal stem cell;Epidermis;epidermis cell;Family;Feeds;Functional disorder;gene function;Genetic;Goals;loss of function;mechanical drive;Mechanics;migration;mouse model;novel;offspring;Parents;Pathway interactions;Play;Population;Proliferating;protein function;Proteins;Publishing;regeneration potential;regenerative biology;regenerative cell;regenerative therapy;regenerative treatment;Regulation;response;Role;Signal Transduction;Skin;skin barrier;skin organogenesis;Skin Physiology;stem cell biology;stem cell niche;stem cell proliferation;stem cells;Structure;Testing;Thick;Tissues;tool;transcription factor;Work;Wound healing therapy

PROJECT_TITLE: Regulatory Functions of the Differentiated Epidermis


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: FARMINGTON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: NARRATIVE We have unearthed emergence of a new subpopulation in cancer cells, which can survive and grow in hypoxic stress by oscillating its oxygen sensing molecular machinery. We propose to understand emergence of these oscillations, their consequence to cancer progression, and develop methods to contain those outcomes.

PI_NAMEs: KSHITIZ, FNU  (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: Automobile Driving;Autophagocytosis;Bioinformatics;Biological;biological adaptation to stress;Breast Cancer Model;Bypass;cancer cell;Cancer Prognosis;cancer stem cell;Cell Cycle Arrest;Cell Proliferation;Cell Survival;Cells;Circadian Rhythms;cofactor;Complex;Computer Models;Data;Environment;Exhibits;extracellular;Feedback;fitness;Frequencies;Gene Expression;gene product;gene regulatory network;Generations;Genes;Genetic Transcription;Glycolysis;Growth;Heterogeneity;Homologous Gene;Hybrids;Hypoxia;Hypoxia Inducible Factor;hypoxia inducible factor 1;Image;in vivo;Invaded;Label;Link;Malignant Neoplasms;mathematical model;Mediating;Metabolic;Methods;Molecular;Molecular Chaperones;mouse model;Mus;Neoplasm Metastasis;novel;Outcome;Oxygen;Pathway interactions;Phenotype;Population;Proliferating;Property;Regulation;response;Role;Signal Transduction;single cell sequencing;spatiotemporal;stemness;Stress;Stromal Invasion;Testing;transcription factor;Transcriptional Regulation;transcriptomics;tumor;Tumor Cell Invasion;tumor growth;tumor hypoxia;tumor microenvironment;tumor progression;tumorigenesis;tumorigenic;Tumorigenicity;Vascularization;Xenograft procedure

PROJECT_TITLE: Investigating the Role of Emergent Oscillations of Hypoxia Inducible Factor-1 alpha Activity in Cancer Growth and Progression

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


ORG_CITY: WINSTON-SALEM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE – OVERALL Adolescence is a critical time of development where teens increase their identification with peers, establish their independence and autonomy, and some begin experimenting with substances, including vaping products. Project MARVEL takes a multidisciplinary approach to assess the impact of youth vaping on health with projects that address vaping behavior, dependence, well-being, brain structure and function, respiratory health, and how to inform adolescents about the health harms to stem the epidemic of youth vaping.

PI_NAMEs: DONNY, ERIC CHRISTIAN;SUTFIN, ERIN L (contact)

PROGRAM_OFFICER_NAME: RODITIS, MARIA LEIA

PROJECT_TERMS: addiction;Address;Adolescence;Adolescent;Adolescent Development;adolescent health;Affect;airway inflammation;Behavior;Biological;Biological Markers;Biostatistics Core;Brain;cerebrovascular;Cluster randomized trial;Cognitive;cognitive development;cognitive skill;Collaborations;community partnership;critical developmental period;Data Collection;Dependence;design;Development;developmental psychology;Ensure;Environmental Risk Factor;Epidemic;Epigenetic Process;Evaluation;experience;Face;Genetic;Genomics;Health;health assessment;health communication;high school;High School Student;human subject protection;improved;Individual;interdisciplinary approach;Intervention;Interview;Life;Literature;Modification;Molecular;multidisciplinary;Neurocognitive;neurodevelopment;Nicotine;nicotine use;novel;operation;oxidative damage;Oxidative Stress;Pathway interactions;Pattern;peer;Personal Satisfaction;Physiological;prevent;Prevention;programs;prospective;psychologic;psychosocial;psychosocial development;Puberty;pulmonary function;recruit;Regulation;Reporting;Research;Research Support;respiratory health;Risk Assessment;Risk Behaviors;Schools;skills;stem;Structure;Surveys;Symptoms;System;systemic inflammatory response;Teenagers;Testing;Time;Tobacco;tobacco regulatory science;Tobacco use;vaping;Youth

PROJECT_TITLE: MARVEL: A Multidisciplinary Assessment of Risks from Vaping during Early Life


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: SAN DIEGO

ORG_NAME: VETERANS MEDICAL RESEARCH FDN/SAN DIEGO

PHR: Project Narrative Impulsivity and compulsivity are core behavioral issues that can exacerbate a wide variety of psychiatric issues, including depression, ADHD, traumatic brain injury and substance abuse. The goals of this project are to identify physiological markers that can be used (instead of or in addition to behavior), as a tool to test for drugs that can ameliorate impulsivity. Thus, we will identify physiological markers of brain function relevant to impulsivity across several tasks; measure whether pharmacologic agents targeting dopamine and serotonin modulate task-relevant oscillations; and finally directly manipulate serotonin and dopamine and measure impacts on physiology and behavior.

PI_NAMEs: MISHRA, JYOTI ;RAMANATHAN, DHAKSHIN  (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: activity marker;Affect;Alcohol dependence;Animals;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior;behavior change;Behavioral;behavioral construct;Behavioral inhibition;behavioral pharmacology;Biological Assay;biomarker identification;Bipolar Disorder;Brain;Brain region;Categories;cell type;Citalopram;Classification;Corpus striatum structure;Cues;Data;design;Development;Diagnostic;Dimensions;discounting;Disease;Dopamine;dopaminergic neuron;dosage;Dose;Drug Addiction;drug testing;Drug usage;Electroencephalography;Electrophysiology (science);Environment;Evaluation;flexibility;Frequencies;Frontotemporal Dementia;Goals;Grant;High Frequency Oscillation;Human;Impairment;improved;Impulsivity;Learning;Link;Measurable;Measures;Medial;Mental Depression;Mental disorders;Modeling;Mood Disorders;Motor;Motor Cortex;Nervous System Disorder;neurophysiology;Neurotransmitters;Obsessive compulsive behavior;optogenetics;Performance;Pharmaceutical Preparations;pharmacologic;Pharmacology;Pharmacology Study;Phase;Physiologic Monitoring;Physiological;Physiological Processes;Physiology;pre-clinical;Prefrontal Cortex;Probability;Process;Research;response;Reversal Learning;Rewards;Ritalin;Serotonin;Specific qualifier value;Substance abuse problem;substance use;suicidal act;System;targeted agent;Testing;therapeutic development;Thinking;tool;translation to humans;Traumatic Brain Injury;Ventral Striatum;Visual

PROJECT_TITLE: Identifying and Targeting Physiological Assays of Circuit Engagement to Improve Impulsivity

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Electronic Nicotine Delivery Systems;Mental Health;Pediatric;Prevention;Tobacco

PHR: NARRATIVE – PROJECT 1: Vaping Behavior, the Emergence of Dependence, and Well-being The use of electronic cigarettes may lead to important health consequences for adolescents including the development of dependence and a reduced capacity to flourish across the different aspects of an adolescent’s life. Project 1 will assess how vaping behavior and the symptoms of vaping dependence emerge during high school and how these changes are related to adolescent well-being. Project 1 will also evaluate how adolescents perceive the relationship between vaping and their daily lives.

PI_NAMEs: DONNY, ERIC CHRISTIAN (contact)

PROJECT_TERMS: addiction;Address;Adolescence;Adolescent;Adolescent Development;adolescent health;Articulation;Attention;Behavior;Behavioral;Biological Markers;Characteristics;Cognitive;cognitive testing;cohort;critical period;daily functioning;Data;Dependence;design;Development;Devices;Dimensions;Disease;Dose;electronic cigarette use;emotion regulation;Emotional;Environmental Risk Factor;experience;Frequencies;Functional disorder;Goals;handicapping condition;Happiness;Health;health communication;high school;High School Student;improved;Individual;Interview;Knowledge;Life;Link;Literature;Longitudinal cohort;Longitudinal Surveys;Marijuana;Measures;Mediating;Mediator;Mental disorders;Methods;Modernization;multidisciplinary;Natural History;Neurobiology;Nicotine;Nicotine Dependence;novel;Participant;Personal Satisfaction;preference;prevent;Prevention;prospective;Psyche structure;psychologic;Recording of previous events;recruit;Reporting;Respiratory physiology;Risk;Risk Assessment;Role;Sampling;skills;social;Social Well-Being;Students;Surveys;Symptoms;System;Time;Tobacco;Tobacco use;vaper;vaping;World Health Organization;Youth

PROJECT_TITLE: Project 1 - Vaping Behavior, the Emergence of Dependence, and Well-being


NIH_SPENDING_CATS: Biotechnology;Genetics;Muscular Dystrophy;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE We have developed a novel strategy to dedifferentiate fibroblasts into induced myogenic progenitors (iMPCs) using a combination of MyoD expression and treatment with small molecules. To our knowledge, iMPCs represent the first expandable and engraftable myogenic cell population with stem/progenitor cell characteristics derived directly from unrelated, differentiated cells. We expect that iMPCs will provide a powerful system to study the mechanisms of cell fate change including muscle development and disease. In three complementary aims, we propose to (i) define the molecular and functional similarity of primitive (Pax7+) iMPC subsets to satellite cells in vivo, (ii) dissect the genetic and epigenetic mechanisms underlying this dedifferentiation process, and (iii) investigate the potential utility of iMPCs to study and treat dystrophy, including an effort to generate human iMPCs. !

PI_NAMEs: HOCHEDLINGER, KONRAD  (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Address;Adult;Affect;Binding;Biological Assay;Biological Models;cell dedifferentiation;Cell Differentiation process;Cell Line;Cell Maintenance;Cell Separation;Cell Therapy;cell type;Cells;Characteristics;ChIP-seq;Chromatin;cofactor;Derivation procedure;Disease;disease model;disease phenotype;DNA;Dystrophin;Engraftment;Enhancers;Epigenetic Process;Exhibits;experimental study;fetal;Fibroblasts;Future;Gene Expression;Gene Mutation;Gene Targeting;gene therapy;Generations;Genes;Genetic;Genetic Transcription;Germ Layers;Hepatocyte;Human;In Vitro;in vivo;Individual;Injury;insight;Knowledge;Maintenance;mdx mouse;Measures;Memory;Modeling;Molecular;Mouse Strains;Mus;Muscle;Muscle Development;Muscle Fibers;muscle regeneration;Muscle satellite cell;Muscular Dystrophies;mutant;MyoD Protein;myogenesis;Myopathy;Neurons;novel strategies;Pattern;Pharmaceutical Preparations;Phenotype;Population;postmitotic;Predisposition;Process;progenitor;Proliferating;Property;Protocols documentation;Publishing;Reporting;Role;self renewing cell;self-renewal;Signal Transduction;Skeletal Muscle;small molecule;Source;Specific qualifier value;Specificity;stem;stem cell self renewal;Stem cell transplant;stem cells;stem-like cell;stemness;synergism;System;Testing;Therapeutic;transcription factor;transcriptome sequencing;transdifferentiation;Transgenes;Transplantation;Undifferentiated

PROJECT_TITLE: Investigating the direct reprogramming of fibroblasts into skeletal muscle progenitors

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Microembolization occurs during coronary stenting, when debris from a coronary narrowing in the vessel wall blocks the microvessels downstream, causing heart damage. There are 600,000 cases of stenting per year. We are developing a novel treatment by using ultrasound to vibrate gas filled microbubbles to clear the debris.

PI_NAMEs: PACELLA, JOHN J (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: 5'-AMP-activated protein kinase;Acoustics;Acute;Acute myocardial infarction;Address;adverse outcome;Age;Alteplase;Animal Model;Arteries;Behavior;Biological Availability;Blood Tests;Blood Vessels;Cell Adhesion;Clinical;clinical translation;Clinical Trials;clinically relevant;comparative efficacy;Congestive Heart Failure;Coronary;Coronary artery;Data;Diagnostic;Distal;effective therapy;EFRAC;Endothelial Cells;Erythrocytes;Failure;Funding;Gases;Goals;heart damage;Hindlimb;Hypotension;improved;in vitro Model;Incidence;indexing;Infarction;Inflammatory;insight;intravenous administration;Ischemia;Legal patent;Lipids;Mechanics;Mediating;Methods;Microbubbles;Microcirculation;Microvascular Permeability;Modeling;mortality;Myocardial;Myocardium;Nitric Oxide;Nitric Oxide Donors;Nitrites;novel;Obstruction;Outcome;Output;Oxidative Stress;Oxides;Pathway interactions;Patient-Focused Outcomes;Patients;percutaneous coronary intervention;Perfusion;Physiologic pulse;Physiological;Plasminogen Activator Interaction;Platelet aggregation;porcine model;protective effect;Rattus;Regulatory Pathway;Reperfusion Therapy;Rodent;Rodent Model;Role;Safety;shear stress;Signal Pathway;Site;Sodium Nitrite;Speed;standard of care;Stents;Swelling;synergism;targeted delivery;Techniques;Technology;Testing;Therapeutic;Therapeutic Embolization;Thrombus;Time;Translating;Translations;Treatment Efficacy;treatment strategy;Trees;Ultrasonic Therapy;ultrasound;Vascular Patency;Vasospasm;vibration;Viscosity;Work

PROJECT_TITLE: Ultrasound Targeted Microbubble Cavitation to Treat Coronary Microvascular Obstruction

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: STANFORD

ORG_DEPT: CHEMISTRY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative The O2 activating iron enzymes that are the focus of this research are widely utilized in Nature and key in human health.1–3 They are involved in antibiotic,4–9 collagen,10 neurotransmitter11,12 and natural product biosynthesis,13–15 bioremediation,16–18 DNA19–25 and hypoxia regulation,26 drug metabolism and toxicity27 and are related to a wide range of diseases.28–36 Understanding their mechanisms on a molecular level enables control of these reactions, enzyme engineering for biotech applications, the rational design of new drugs, and provides the insights required to develop new chemistries and catalysts.

PI_NAMEs: SOLOMON, EDWARD I (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TITLE: Spectroscopic Characterization of Oxygen Intermediates in Non-heme and Heme Iron Enzymes


ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: Innovative approaches are needed to improve uptake of evidence-based interventions and to de-implement ineffective and harmful practices, such as inappropriate antimicrobial use. The long-term goal of this implementation study is to improve the health and longevity of Veterans undergoing cardiac device procedures by leveraging a novel clinical informatics tool applied to the VA electronic medical record with the capabilities to track rates of compliance with clinical guidelines and post-procedural outcomes to promote adoption of best antimicrobial use practices. Lessons learned about how a multi-faceted implementation strategy including automated audit and feedback can be used to improve uptake of guidelines and de-implementation of ineffective practices will advance the field of implementation science and improve outcomes for cardiac device recipients.

PI_NAMEs: BRANCH-ELLIMAN, WESTYN  (contact)

PROJECT_TERMS: Accounting;Acute Renal Failure with Renal Papillary Necrosis;Adoption;Adverse event;adverse outcome;Age;Algorithms;antimicrobial;Antimicrobial Resistance;Area;cardiac device;Cardiovascular system;Caring;Cessation of life;Clinical;clinical care;Clinical effectiveness;Clinical Informatics;clinical practice;Clostridium difficile;Communicable Diseases;Computerized Medical Record;Data;Defibrillators;Deimplementation;design;Devices;Diffusion;disorder control;disorder prevention;Documentation;Education;Effectiveness;electronic data;Electronic Health Record;Electronics;Electrophysiology (science);evidence base;Evidence based intervention;Feedback;formative assessment;Goals;Guidelines;Health;healthcare-associated infections;Hour;Hybrids;Implant;implementation outcomes;implementation science;implementation strategy;implementation study;improved;improved outcome;Infection;Infection Control;Infection prevention;Informatics;informatics tool;Information Systems;Injury to Kidney;innovation;insight;Interruption;Interview;Learning;Life;Longevity;Manuals;Measurement;Measures;Medical Records;member;Methodology;Methods;Morbidity - disease rate;mortality;novel;Outcome;Outcome Measure;Outpatients;Pacemakers;Population;prevent;primary outcome;Procedures;Process;programs;Prophylactic treatment;Provider;Quality of Care;Recommendation;Reporting;Research;Research Personnel;Research Priority;Resistance to infection;Resources;Site;Skin;Surgical incisions;System;Testing;Time;Time Series Analysis;tool;Translating;uptake;Veterans;Work

PROJECT_TITLE: Promoting De-Implementation of Inappropriate Antimicrobial Use in Cardiac Device Procedures By Expanding Audit and Feedback

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Electronic Nicotine Delivery Systems;Neurosciences;Pediatric;Prevention;Tobacco

PHR: NARRATIVE – PROJECT 2: Impact of Adolescent Vaping on Brain Health A comprehensive understanding of the risks during adolescent development is urgently needed. Project 2 assesses how vaping nicotine longitudinally changes the brain and associated cognitive/psychosocial function, as well as innovative information about how these changes may be impacted by vaping-associated effects on autonomic nervous system function.

PI_NAMEs: WHITLOW, CHRISTOPHER T (contact)

PROJECT_TERMS: Acrolein;Adolescence;Adolescent;Adolescent Development;Adult;Aerosols;Affect;Amygdaloid structure;Animal Model;Anterior;Area;Attention;Autonomic nervous system;Baroreflex;Behavioral;Biological Markers;Brain;brain health;Brain region;Cerebrovascular Circulation;cerebrovascular reactivity;Characteristics;Chemicals;Cholinergic Receptors;cingulate cortex;Cognitive;cognitive development;Data;Development;Dose;Emotions;Equilibrium;Exclusion;Exclusion Criteria;executive function;Frequencies;Goals;Health;heart rate variability;Hippocampus;Human;Hypercapnia;Inferior frontal gyrus;innovation;interest;Life;Literature;Magnetic Resonance Imaging;marijuana use;Measures;Mediating;Memory;multidisciplinary;Nervous System;Nervous System control;Nervous System Physiology;Nicotine;novel;Outcome;Participant;Performance;Personal Satisfaction;phenotypic biomarker;Physiological;Physiological Processes;pre-clinical;Prefrontal Cortex;Prevention;psychosocial;psychosocial development;recruit;Regulation;Reporting;Research;Rewards;Risk;Risk Assessment;Smoking;social cognition;Structure;Surveys;Testing;Time;Tobacco smoking behavior;tobacco user;vaper;vaping;vaping nicotine;Ventral Striatum

PROJECT_TITLE: Project 2 - Impact of Adolescent Vaping on Brain Health


PHR: Clostridium difficile is a major pathogen causing serious healthcare-associated diarrheal illness in veterans. Prevention of healthcare facility-onset of C. difficile infection (CDI) is essential. A significant proportion of CDI is caused by transmission of the pathogen from asymptomatic colonized patients. However, data on interventions focusing on colonized patients are sparse. Universal gloving by healthcare workers for all patient contacts may reduce CDI. The work proposed will examine the effectiveness of universal gloving versus standard of care in a cluster randomized trial for preventing C. difficile acquisition and CDI, the results of which will inform infection control measures for CDI prevention throughout the VA.

PI_NAMEs: SAFDAR, NASIA  (contact)

PROJECT_TERMS: Admission activity;Affect;American;Antibiotic-resistant organism;Antibiotics;Antimicrobial Resistance;Antisepsis;Biological;Caring;Cessation of life;Clostridium difficile;Clothing;Cluster randomized trial;Colon;Communicable Diseases;Communities;comorbidity;Containment;cost;Data;Decontamination;Diagnostic tests;Diarrhea;diarrheal disease;Disease;Disease Outbreaks;Disinfection;effectiveness evaluation;Environment;Environmental Pollution;Equipment;evidence based guidelines;experience;Exposure to;Goals;Hand;Health;Health care facility;health care settings;Health Personnel;Healthcare;healthcare-associated infections;Hospital Units;Hospitalization;Hospitals;human old age (65+);Hygiene;improved;Incidence;Infection;Infection Control;Infection prevention;infection rate;infection risk;Inpatients;Institutional Review Boards;Interruption;Intervention;Laboratory Technicians;Length of Stay;Measures;Medical;methicillin resistant Staphylococcus aureus;Methods;Microbiology;modifiable risk;Monitor;Morbidity - disease rate;mortality;multi-drug resistant pathogen;new epidemic;Nurses;Organism;pathogen;patient safety;Patients;Patients' Rooms;Perception;Perforation;prevent;Prevention;Prevention Measures;programs;Provider;Pseudomembranous Colitis;public health priorities;Radiology Specialty;Randomized;Recommendation;recruit;Reproduction spores;Research;Research Assistant;Research Training;Resistance;Resources;respiratory;Risk Factors;screening;Secure;Site;Societies;standard care;standard of care;Surface;Testing;Time;Toxic Megacolon;transmission process;United States;Veterans;Work

PROJECT_TITLE: Effect of Expanding Barrier Precautions for Reducing Clostridium difficile Acquisition in VA.


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Hearing Loss;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: The goal of the proposed research is to identify the circuits for learning to hear in noise. This is achieved by using a combination of electrophysiological, imaging, optogenetic and behavioral approaches in the mouse system. Verbal communication and auditory navigation require rapid reorganization of the representation of the acoustic environment under varying behavioral demands. Patients with hearing deficits, age-related hearing loss and communication deficits, as well as patients with hearing aids and cochlear implants exhibit extreme difficulty hearing in complex acoustic environments, and especially transitioning between different environments with varying noise levels. Identifying which neuronal circuits underlie the ability to modify the representation of complex acoustic scenes, is a prerequisite for development of new and improvement of existing therapies for these large groups of patients. In particular, these important insights into the function of feedback circuits in auditory processing will inform future design of hearing aids and cochlear implants by configuring their outputs for optimal stimulation of these circuits.

PI_NAMEs: GEFFEN, MARIA NEIMARK (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustics;Affect;Area;Auditory;Auditory area;Auditory Perception;auditory processing;auditory thalamus;Behavior;Behavioral;Biological Assay;Cells;Cochlear Implants;Communication;Complex;Computer Models;Data;design;Detection;Development;Discrimination;discrimination task;Electrophysiology (science);Elements;Environment;Exhibits;Feedback;Funding;Future;Geniculate body structure;Goals;Hearing Aids;hearing impairment;Image;Impairment;improved;inhibitory neuron;insight;Interneurons;Knowledge;Learning;Linear Models;Measures;Medial;Mus;neural;neuronal circuitry;Neurons;Noise;Non-linear Models;novel;Operant Conditioning;Optics;optogenetics;Output;Parvalbumins;Patients;Play;Population;Presbycusis;Process;Research;response;Role;Signal Transduction;Somatostatin;sound;speech in noise;Stimulus;System;Testing;Thalamic structure;Thinness;Training;Vasoactive Intestinal Peptide;verbal;Work

PROJECT_TITLE: Neuronal circuits supporting learning-driven changes in auditory perception


NIH_SPENDING_CATS: Cancer;Clinical Research;Electronic Nicotine Delivery Systems;Genetics;Lung;Lung Cancer;Pediatric;Prevention;Tobacco;Tobacco Smoke and Health

PHR: NARRATIVE – PROJECT 3: Lung Health and Inflammation The health risks associated with vaping are not yet well understood. Project 3 will evaluate the effects of vaping in adolescence on early changes in respiratory health, oxidative stress and inflammation. Knowledge gained from Project 3 will inform on the potential of vaping to alter respiratory health as early as adolescence, and the potential for vaping to modify pathways known to contribute to tobacco-related lung disease and extrapulmonary diseases, including atherosclerosis and cancer.

PI_NAMEs: HAWKINS, GREGORY A (contact)

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;Affect;Airway Disease;airway inflammation;Aryl Hydrocarbon Receptor;Asthma;Atherosclerosis;Biological;biological adaptation to stress;Biological Markers;Blood;Brain;bronchial epithelium;Chronic;Chronic Obstructive Pulmonary Disease;Cigarette Smoker;cigarette smoking;Cognitive;cohort;Collaborations;Collection;Cotinine;Coughing;Dependence;Development;Disease;DNA Methylation;Dose;Early Diagnosis;Epigenetic Process;epigenome;Epithelial Cells;exposure to cigarette smoke;Future;Gene Expression;Genes;Genetic Transcription;Health;health communication;High School Student;Immune;Impairment;Inflammation;Inflammatory;innovation;Knowledge;Life;Link;lung development;Lung Diseases;lung health;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Mediation;Methods;minimally invasive;Molecular;Molecular Profiling;Mucins;multidisciplinary;multiple omics;Nasal Epithelium;Outcome;oxidative damage;Oxidative Stress;Pathogenesis;Pathogenicity;Pathway Analysis;Pathway interactions;Patient Self-Report;peripheral blood;Phenotype;Physiological;Production;psychosocial;Public Health;pulmonary function;Pulmonary Inflammation;Questionnaires;Receptor Signaling;Research;respiratory;respiratory health;Risk;Risk Assessment;Saliva;sample collection;Smoker;Smoking;smoking-related disease;Spirometry;Sputum;Stress;Structure;Surveys;Symptoms;systemic inflammatory response;Testing;Time;Tobacco;transcriptome;transcriptomics;vaper;vaping;Variant;Vascular Diseases;Visit;Xenobiotic Metabolism

PROJECT_TITLE: Project 3 - Lung Health and Inflammation


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Conditions Affecting the Embryonic and Fetal Periods;Congenital Structural Anomalies;Dietary Supplements;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Maternal Health;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Public Health Relevance Given the limited effectiveness of informational and psychosocial interventions in addressing the continuing major health risks associated with maternal heavy alcohol consumption and binge drinking during pregnancy, there is growing interest in new approaches, such as nutritional interventions, that may be more effective in reducing the risks associated with fetal alcohol spectrum disorders (FASD). Extensive data from animal studies and preliminary data from our R21 maternal choline supplementation feasibility study suggest that daily supplementation with a high dose of the nutrient choline initiated early in pregnancy can be effective in mitigating a range of adverse effects on growth and neurobehavioral function seen in FASD. The proposed fully-powered, phase II, double blind, randomized placebo-controlled trial is designed to confirm these findings, thereby providing the basis for implementation of this promising, highly innovative intervention in clinical settings.

PI_NAMEs: CARTER, ROBERT COLIN;JACOBSON, JOSEPH L;JACOBSON, SANDRA W. (contact);MEINTJES, ERNESTA MARIA

PROGRAM_OFFICER_NAME: DUNTY, JR, WILLIAM

PROJECT_TERMS: Acetylcholine;Address;Adherence;Adverse effects;Alcohol consumption;alcohol consumption during pregnancy;alcohol effect;alcohol exposure;Alcoholic beverage heavy drinker;Alcohols;animal data;Animal Model;Animals;antenatal care;Area;arm;Back;Behavioral;binge drinking;Birth;Body Weight;Brain;Cell membrane;Cellular Structures;Child;Choline;Choline Deficiency;choline supplementation;Clinical;Cognition;Cognitive;cognitive development;cognitive function;Color;Communities;Controlled Clinical Trials;Data;design;Developmental Delay Disorders;dietary;Dietary Intervention;Dietary Supplementation;DNA Methylation;Dose;Double-Blind Method;Dysmorphology;Early treatment;Effectiveness;effectiveness evaluation;efficacy evaluation;Enrollment;eyeblink conditioning;Feasibility Studies;feasibility trial;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fetal Alcohol Syndrome;Fetal Growth;Folic Acid;Growth;Growth and Development function;Head circumference;Health;Heavy Drinking;High Prevalence;Human;human study;implementation facilitation;implementation intervention;Incidence;Infant;information processing;innovation;Intake;Intelligence;interest;Intervention;Interview;Learning;Length;maternal alcohol use;Measures;memory recognition;Methods;methyl group;Mothers;Motor;National Institute on Alcohol Abuse and Alcoholism;neurobehavioral;Neurotransmitters;non-compliance;novel strategies;Nursing Research;Nutrient;Nutritional status;Participant;Phase;Physiological;Placebo Control;placebo group;Placebos;Plasma;postnatal;Postpartum Period;Pregnancy;Pregnant Women;Prenatal care;Prevalence;primary outcome;processing speed;Protocols documentation;psychosocial;public health relevance;Randomized;randomized placebo controlled trial;Rattus;recruit;Reflex action;Research;Research Priority;Risk;Risk Reduction;Rural;Sampling;School-Age Population;secondary outcome;Short-Term Memory;sociodemographic factors;Source;South Africa;Supplementation;Testing;Third Pregnancy Trimester;Time;timeline;Treatment Efficacy;Universities;Variant;Visit;way finding;Weight;Woman

PROJECT_TITLE: A Randomized, Double-Blind, Placebo-controlled Clinical Trial of Choline Supplementation during Pregnancy to Mitigate Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Development

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Opioid Misuse and Addiction;Opioids;Pain Research;Patient Safety;Prescription Drug Misuse;Prevention;Primary Health Care;Screening and Brief Intervention for Substance Misuse;Substance Misuse;Substance Misuse Prevention

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE  Previous research, including that of our team, shows that a significant portion of those regularly using opioids—particularly filling opioids at community pharmacies—also are involved in the co-use of alcohol. This study proposes to adapt a previously developed intervention for opioid medication misuse; test its acceptability, feasibility, and preliminary efficacy; and identify barriers and facilitators to large-scale research and system-level implementation. Results of this study will directly inform a fully-powered subsequent multisite trial.

PI_NAMEs: COCHRAN, GERALD T. (contact);HOHMEIER, KENNETH CHARLES

PROGRAM_OFFICER_NAME: BALACHOVA, TATIANA NIKOLAYEVNA

PROJECT_TERMS: Address;Adoption;alcohol abuse therapy;Alcohol consumption;alcohol intervention;alcohol measurement;alcohol prevention;alcohol screening;alcohol seeking behavior;alcohol use disorder;Alcohols;Analgesics;Back;brief intervention;Client satisfaction;Clinical Research;clinical trial protocol;Clinical Trials;Community Pharmacy;comorbidity;comparison control;Consent;Consolidated Framework for Implementation Research;Consultations;Consumption;Counseling;Data;drinking;Enrollment;Evaluation;feasibility testing;Future;hazard;Health;Heavy Drinking;high risk drinking;improved;Individual;insight;Intervention;Interview;Location;Manuals;Medication Management;Mental Depression;Mental Health;Methods;mu opioid receptors;multi-site trial;non-opioid analgesic;Opiate Addiction;Opioid;Opioid Analgesics;opioid epidemic;opioid use;opioid use disorder;organizational readiness;Outcome;overdose risk;Pain;Pain management;Participant;participant retention;patient screening;Patients;Pattern;Peer Review;Perception;Pharmaceutical Preparations;Pharmacists;Pharmacy facility;Positioning Attribute;prescription opioid;prescription opioid misuse;Process;Production;Public Health;Randomized;randomized trial;Reporting;Research;Resources;Review Literature;Risk;Safety;screening;screening, brief intervention, referral, and treatment;Sedation procedure;Site;System;systems research;team-based care;telephone based;Testing;timeline;Toxicology;Training;Urine;Ventilatory Depression;Work

PROJECT_TITLE: Co-Use of Opioid Medications and Alcohol Prevention Study (COAPS)

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Ovarian Cancer;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: Project Narrative Ovarian cancer (OC) is the most lethal gynecologic malignancy, with 90% of women diagnosed receiving chemotherapy. Timely and successful completion of chemotherapy is critical as delayed or reduced chemotherapy dosage for OC is associated with decreased survival, yet chemotherapy dose delays and dose reductions are common (~30% to 50% of OC patients), with the primary reason for dose delays and reductions being chemotoxicity. We propose to conduct a multi-site randomized trial of an 18-week medical nutrition therapy and exercise intervention vs attention control in a racially and ethnically diverse sample of 200 women newly diagnosed with OC (stage I-IV) and initiating curative intent chemotherapy to assess the effect of the intervention on chemotherapy completion rates, patient-reported chemotoxicities, and body composition.

PI_NAMEs: CRANE, TRACY E;IRWIN, MELINDA L (contact)

PROGRAM_OFFICER_NAME: GREENBERG, DEBORAH B

PROJECT_TERMS: Acceleration;Address;Aftercare;aggressive therapy;arm;Arthralgia;attentional control;Attenuated;Behavior;behavior change;Biological Markers;Black Populations;Body Composition;Cancer Patient;cancer survival;Cancer Survivor;chemotherapy;cognitive function;common treatment;comorbidity;Creatine;Diagnosis;Diet;diet and exercise;Dietary Intervention;Disease;Disease-Free Survival;Disparity;dosage;Dose;Enrollment;ethnic disparity;ethnic diversity;Ethnic Origin;Exercise;exercise intervention;experience;Fatigue;feasibility trial;follow-up;gastrointestinal;Gynecologic Oncology Group;health care service utilization;Healthcare;healthy lifestyle;Hispanic Populations;Home;Image;Impaired cognition;improved;Intervention;intervention effect;Life Style;lifestyle intervention;Malignant Breast Neoplasm;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Measures;Medical Nutrition Therapy;Mental Depression;Methods;mortality;muscle form;Muscular Atrophy;Neuropathy;Newly Diagnosed;Not Hispanic or Latino;nutrition;Obesity;Operative Surgical Procedures;Outcome;Patients;Physical activity;Platinum;post intervention;primary endpoint;Quality of life;Race;racial disparity;racial diversity;Randomized;randomized trial;Randomized, Controlled Trials;Reporting;Research;Resources;Sample Size;Sampling;sarcopenia;Site;Stage at Diagnosis;standard of care;Survival Rate;taxane;Testing;Time;Toxic effect;Toxicity due to chemotherapy;treatment optimization;urinary;Visit;Walking;White Women;Woman;women's diagnosis;Women's study;Work;X-Ray Computed Tomography

PROJECT_TITLE: Trial of Exercise and Lifestyle (TEAL) in Women with Ovarian Cancer


NIH_SPENDING_CATS: Genetics

ORG_CITY: Boulder

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE Telomeres are nucleoprotein structures that protect the ends of chromosomes from replicative erosion, nucleolytic degradation and from the DNA damage signaling and repair pathways. While telomeres are considered to be heterochromatic, their exact chromatin composition remains debated and, more importantly, whether heterochromatin is important for telomere functions and regulation remains elusive. Using a novel approach, we will modulate histone modifications specifically at telomeres and determine the function of heterochromatin marks in the biology of telomeres.

PI_NAMEs: ARNOULT, NAUSICA C. (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Aging;Binding;Biology;Buffers;Cancerous;Cell Aging;Cell Cycle Arrest;Cells;Chromatin;Chromosomes;Code;Complex;Consensus;Data;Defect;derepression;Development;DNA;DNA Damage;Enzymes;Genetic Recombination;Genetic Transcription;Genome Stability;Heterochromatin;histone methylation;histone modification;Histones;Maintenance;Methylation;Mitotic;neglect;non-histone protein;novel strategies;Nucleoproteins;Nucleosomes;Pathway interactions;Play;prevent;Property;Proteins;Regulation;repaired;Role;senescence;Signal Transduction;Structure;Telomerase;telomere;Telomere Maintenance;Telomeric Repeat Binding Protein 1;tumor

PROJECT_TITLE: Deciphering the role of heterochromatin in telomere function and maintenance mechanisms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-I(55)R]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Underrepresented minorities in medicine (URM) physicians are critical providers for our increasingly diverse nation and underserved populations, yet little is known about how fairly their performance is assessed during their key formative years in Graduate Medical Education. Using a national integrated dataset, we will examine whether discriminatory biases are observed for URM resident physicians as measured by standardized national assessments in U.S.-accredited family medicine and internal medicine residency programs. Results will inform national policies to promote minority health and to improve the training needs for URM physicians who serve as a critical workforce to address health disparities that persist in the U.S.

PI_NAMEs: KIM, JUNG G. (contact)

PROGRAM_OFFICER_NAME: PATEL, ANURADHA DIPAK

PROJECT_TERMS: Academy;Accreditation;Address;Age;Communities;Competence;County;Data;data integration;Data Set;design;Development;Disparity;Educational Assessment;educational atmosphere;ethnic disparity;Ethnic Origin;experience;Faculty;Family Practice;Female;Fostering;Gender;Goals;graduate medical education;Growth;health disparity;improve minority health;improved;Individual;Inequity;Internal Medicine;Learning;Licensing;Logistic Regressions;Measurable;Measurement;Measures;Medical Education;medical specialties;Medical Students;Medicine;minority health;Modeling;Outcome;patient population;Performance;Physicians;Policies;Population;Primary Care;Primary Care Physician;programs;Provider;Quality of Care;Race;racial bias;racial disparity;recruit;Reduce health disparities;Reporting;Residencies;response;Source;standardize measure;Strategic Planning;Testing;Training;Training Programs;Underrepresented Minority;underserved community;Underserved Population;United States National Institutes of Health;Variant;Woman;women faculty;workforce needs

PROJECT_TITLE: Factors associated with assessment bias for underrepresented minorities resident physicians training in family medicine and internal medicine

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Electronic Nicotine Delivery Systems;Pediatric;Prevention;Tobacco;Tobacco Smoke and Health

PHR: NARRATIVE – ADMINISTRATIVE CORE Project MARVEL takes a multidisciplinary approach to assess the impact of youth vaping on health with projects that address vaping behavior, dependence, well-being, brain health and cognitive and psychosocial development, respiratory health, and how to inform adolescents about the effects of vaping. Conducting the type of translational and participatory adolescent research proposed in Project MARVEL is challenging. The Administrative Core will address these challenges by managing operations; facilitating scientific discussion, and integration; and supporting dissemination.

PI_NAMEs: SUTFIN, ERIN L (contact)

PROJECT_TERMS: addiction;Address;Adolescent;Adolescent Development;adolescent health;Aerosols;Affect;Behavior;Benchmarking;Biological Markers;Biometry;Brain;brain health;Cancer Center Support Grant;Characteristics;Cigarette;Clinical Trials;cognitive development;Collaborations;Communication;community engagement;Complex;data sharing;Dependence;design;Development;Discipline;Endowment;Ensure;Epidemic;Evaluation;experience;Funding;Generations;Goals;Grant;Health;health communication;Health Policy;human subject protection;innovation;interdisciplinary approach;Lead;Life;Literature;Manuscripts;Measurement;Medicine;meetings;Monitor;multidisciplinary;multiple omics;National Institute of Drug Abuse;Nicotine;Nicotine Dependence;North Carolina;Oncology;operation;Personal Satisfaction;Pharmacology;Physiology;Pilot Projects;Play;Policies;Positioning Attribute;prevent;Principal Investigator;Process;professor;programs;Protocols documentation;Psychology;psychosocial development;Public Health;recruit;Reporting;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Support;respiratory health;Risk Assessment;Role;Schools;Science;Science Policy;Services;smoking cessation;Social Sciences;success;System;Tobacco;tobacco control;tobacco regulatory science;Toxicology;Travel;U-Series Cooperative Agreements;United States National Institutes of Health;Universities;vaping;Work;Youth

PROJECT_TITLE: Administration Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Rare Diseases

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Cholera, a severe dehydrating diarrheal disease caused by Vibrio cholerae, remains a global threat to public health. In this project, we will study the processes that control the pathogen’s intestinal colonization, the host intestinal responses to experimental cholera, and the factors that control the pathogen’s transmissibility. This work will yield new understanding of the interactions between V. cholerae and the host and has important implications for creation of new cholera therapeutics and vaccines.

PI_NAMEs: WALDOR, MATTHEW K (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: Address;Area;Bacteria;Bar Codes;base;Biology;Cholera;Cholera Toxin;computer framework;defense response;Dehydration;design;Diarrhea;diarrheal disease;enteric pathogen;Environment;Epidemic;experience;fitness;Fluids and Secretions;Genes;Genetic Transcription;Grant;Growth;gut colonization;Host Defense;Human;Immune Evasion;in vivo;Infection;Innate Immune Response;insight;Integration Host Factors;intestinal epithelium;Intestines;Investigation;Link;Liquid substance;Mediating;Metabolism;Methylation;Modeling;Morbidity - disease rate;mortality;novel strategies;O Antigens;pandemic disease;pathogen;Pathogenesis;Pathway interactions;Phenotype;Physiological;Predisposition;prevent;Process;Protein Secretion;Proteins;Public Health;Pulmonary Surfactant-Associated Protein D;Research;response;Rod;Role;Serotyping;Shapes;Small Intestines;sugar;Testing;Therapeutic;tool;Transcript;transmission process;Vaccines;Variant;Vibrio cholerae;Vibrio cholerae infection;Vibrio cholerae O1;Work

PROJECT_TITLE: Host-pathogen interactions in experimental cholera

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-W(80)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE This project will leverage two unique longitudinal cohorts to examine relationships between exposure to community violence over the lifecourse, and risk of cognitive decline and Alzheimer’s and related dementias among African-Americans. The findings will have a positive impact by identifying how social policies that affect African-American populations from childhood through adulthood can mitigate ADRD incidence in later life.

PI_NAMEs: KO, MICHELLE JASSMINE (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Address;Adolescence;Adult;Affect;African American;African American population;Age;aging brain;Alzheimer's disease related dementia;behavior measurement;Behavioral;Birth;built environment;Cessation of life;Characteristics;Childhood;Chronic;Cities;Cognitive;cognitive function;cohort;Communities;community violence;Complex;Computerized Medical Record;Crime;Cross-Sectional Studies;Data;dementia risk;Deterioration;Development;Dimensions;Disadvantaged;Discrimination;Disparity;Education;Elderly;emerging adult;Employment;Epidemic;Event;experience;Exposure to;falls;Female;Funding;Gender;Geography;Goals;Health;health data;health record;healthy aging;Homicide;Hypertension;Impaired cognition;Imprisonment;Incidence;Income;Inequity;late life;Lead;Life;Life Cycle Stages;Life Experience;life span;Link;longitudinal analysis;Longitudinal cohort;male;Measures;Mediating;Mental Health;middle age;National Institute on Aging;Neighborhoods;Not Hispanic or Latino;Obesity;older adult;Participant;participant interview;Pathway interactions;Physiological;Police;Policies;Population;Process;programs;Public Health;racial disparity;racism;Recording of previous events;recruit;Research;Resources;Risk;Risk Factors;risk mitigation;sex as a biological variable;social;Social Network;Social Policies;social structure;socioeconomic disadvantage;Street Address;Stress;Structural Racism;substance use;Time;Violence;violence exposure;violent crime

PROJECT_TITLE: Lifecourse exposure to community violence and risk of cognitive decline, Alzheimer's Disease, and related dementias among African-Americans

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Narrative The Public Health Relevance of the MARC Program at Temple University is related to its significant impact on preparing underrepresented and disadvantaged students to successfully complete the undergraduate degree and pursue a PhD or MD/PhD in biomedical sciences, ultimately increasing the diversity of PhD-level scientists that bring diverse perspectives to investigate health issues to reduce health disparities. The MARC program is a university-wide collaboration between College of Science and Technology and Research Centers at Lewis Katz School of Medicine at Temple University, which will enhance mentored-research projects and science- based activities. As a result, MARC scholars who are more aware of and engaged in health disparities research in underserved minority communities, will be more likely to pursue a long-term career in the field of biomedical sciences.

PI_NAMEs: MA, GRACE X.;MATSIKA, SPIRIDOULA  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Address;Agreement;Area;Behavioral Research;Biomedical Engineering;Biomedical Research;cancer health disparity;CCL7 gene;cohort;college;Communication;community engagement;Discipline;Disparity population;Doctor of Philosophy;Education;Emotional Intelligence;Engineering;Enrollment;Ensure;Ethnic Population;Faculty;faculty mentor;First Generation College Students;Funding;Goals;graduate school;hands on research;Health Disparities Research;Hispanic;improved;interest;medical schools;Mentors;Mentorship;Mission;Occupations;Outcome Measure;Philadelphia;programs;Public Health;Publications;racial population;Research;Research Support;Research Training;Schools;Science;social skills;Students;Study Skills;success;Technology;Training;undergraduate research experience;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;university student

PROJECT_TITLE: MARC at Temple University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Cancer;Data Science;Electronic Nicotine Delivery Systems;Networking and Information Technology R&D (NITRD);Prevention;Tobacco

PHR: NARRATIVE – CORE 001: Biostatistics Core The Biostatistics Core will provide comprehensive support of the population and lab-based studies that comprise this Program Project from study design, sampling, quality control and database management to biostatistical analysis and dissemination. Through a coordinated collaboration between this Core and each project, we will ensure an efficient means of collecting and managing data and the application of a rigorous analytic methodology across studies that supports the overall conceptual framework for the Program Project.

PI_NAMEs: REBOUSSIN, BETH A. (contact)

PROJECT_TERMS: Adolescent;arm;Baptist Church;benefit sharing;Bioinformatics;biomedical informatics;Biometry;Biostatistics Core;Biostatistics Shared Resource;Cardiovascular Diseases;Cataloging;Cluster randomized trial;Collaborations;Collection;Comprehensive Cancer Center;Consultations;Cross-Sectional Studies;Data;Data Analyses;data cleaning;Data Collection;Data Coordinating Center;Data Element;data integration;data management;Data Management Resources;Data Science;Data Set;data sharing;Data Storage and Retrieval;database design;Database Management Systems;Databases;design;Documentation;Ensure;experience;Formulation;Funding;Health behavior;health communication;Health Sciences;Image;Individual;Infrastructure;Intervention;Laboratory Procedures;Life;Longitudinal cohort study;Malignant Neoplasms;Measurement;medical schools;member;Metadata;Methodology;Mission;Monitor;multidisciplinary;Online Systems;Outcome;Participant;Persons;Population;Probability Samples;Procedures;programs;Public Health;quality assurance;Quality Control;Randomized;recruit;relational database;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Resource Sharing;Risk Assessment;Sample Size;Sampling;Schools;Secure;Services;skills;Statistical Data Interpretation;statistics;Stratification;Surveys;synergism;Technical Expertise;Techniques;United States National Institutes of Health;vaping;Weight

PROJECT_TITLE: Core 1 - Biostatistics


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: LA JOLLA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE A persistent issues in the treatment of cocaine addiction is the reinstatement of cocaine seeking even after the long period of withdrawal. The goal of this proposal is to take advantage of recent technological advances to dissect and identify specific neural circuitry and neural adaptions as well as molecular mechanisms that underlie the reinstatement of cocaine seeking after the withdrawal, with the ultimate goal of contributing to the treatment of the drug addiction.

PI_NAMEs: LIM, BYUNGKOOK  (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Abstinence;Addictive Behavior;Anatomy;Area;Automobile Driving;Behavior;Brain;Chronic;Cocaine;Cocaine Dependence;cocaine seeking;cocaine self-administration;cocaine use;Cocaine withdrawal;Communication;conditioned place preference;craving;Data;Dimensions;Dopamine;Dopamine Receptor;dopaminergic neuron;Drug abuse;Drug Addiction;drug craving;Drug Modelings;drug of abuse;drug seeking behavior;Electrophysiology (science);feeding;Fiber;Fluorescent in Situ Hybridization;genetic manipulation;Globus Pallidus;Goals;Habenula;Imaging Techniques;in vivo;in vivo monitoring;insight;knock-down;Lateral;Lesion;Light;Measurement;Mediating;Methods;Midbrain structure;Modeling;Molecular;Molecular Profiling;Monitor;Motivation;Mus;neural;neural circuit;neuroadaptation;neuromechanism;neuronal circuitry;Neurons;Nucleus Accumbens;optogenetics;Output;Pathway interactions;Pharmaceutical Preparations;Photometry;Play;Population;Prevalence;Process;Property;response;reward circuitry;reward processing;Rewards;Role;Satiation;Self Administration;sensor;Signal Pathway;Signal Transduction;small hairpin RNA;Stressful Event;Structure;Subthalamic structure;Synapses;System;targeted treatment;Techniques;Technology;therapeutic development;tool;Transgenic Mice;treatment strategy;Ventral Tegmental Area;Viral;Withdrawal

PROJECT_TITLE: Dissecting the role of ventral pallidal circuitry in cocaine seeking after the withdrawal

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]