NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Neurosciences;Nutrition;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: Aurora

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Our sense of taste is mediated by taste buds on the tongue that allow us to choose what to eat and what to avoid. Taste function is perturbed by a host of factors, ranging from viral infection, e.g. COVID-19, to cancer therapies, but we have little understanding of the underlying effects on taste buds themselves. Here, we will develop tissue culture techniques to grow taste buds from lingual tissue of recently deceased human donors, with the longer-term goal of understanding how disease and cancer drugs affect human taste buds directly and by extrapolation, taste function in patients.

PI_NAMEs: BARLOW, LINDA A (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: 2019-nCoV;Acceleration;Adult;adult stem cell;Affect;Antineoplastic Agents;Autopsy;Bioinformatics;Biopsy;cancer therapy;cell immortalization;Cell Line;Cells;cellular transduction;Collection;Colon;COVID-19;Culture Media;Data Set;density;Derivation procedure;Detection;Development;Diameter;differential expression;Disease;Dissociation;Dysgeusia;Eating;Epithelial Cells;Epithelium;Feedback;Female;fighting;Freezing;Functional disorder;Gene Expression;Gene Expression Profile;Genes;Goals;Grant;Harvest;healthy volunteer;Histologic;Homeostasis;Human;human female;human model;human tissue;Immunofluorescence Immunologic;In Situ Hybridization;in vitro Model;Individual;Ingestion;Integration Host Factors;intestinal injury;Intestines;Life;Lung;male;Malignant Neoplasms;Mediating;medically necessary care;Mesenchyme;Messenger RNA;Methods;Modeling;Molecular;Moths;Mus;Natural regeneration;next generation sequencing;Organ;Organ Donor;Organ Procurements;Organoids;Pancreas;pathogen;Pathology;Patients;Pharmaceutical Preparations;Population;Process;Production;Property;Protocols documentation;Quantitative Reverse Transcriptase PCR;Reaction;Receptor Cell;Research Design;Resource Sharing;response to injury;Sampling;Sensory;Serial Passage;single-cell RNA sequencing;skills;Sodium Chloride;stem cell biomarkers;stem cell population;stem cells;Surgeon;Taste Bud Cell;Taste Buds;Taste Perception;taste system;Technology;Tissue Culture Techniques;Tissue Donors;Tissue Model;Tissue Procurements;Tissue Sample;Tissues;Tongue;tongue papilla;Virus Diseases;Work

PROJECT_TITLE: Development of human taste organoid models

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Infectious Diseases

ORG_CITY: HANOVER

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Phase II COBRE funding will strengthen and enhance the Dartmouth Institute for Biomolecular Targeting, which supports innovative strategies to enhance understanding of biological mechanisms and translation of that knowledge into clinical practice. The Institute will continue to catalyze the development of new therapeutic approaches to address cancer, respiratory infections, and other diseases. It also provides unique resources to investigators at Dartmouth and our IDeA partners, enhancing research productivity and funding competitiveness across the region.

PI_NAMEs: MADDEN, DEAN R (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: 2019-nCoV;Acceleration;Address;Antibodies;Area;Autophagocytosis;Award;Awareness;Binding;Biological;Businesses;career;Career Mobility;Centers of Research Excellence;clinical practice;cohort;Communities;community building;Complex;Consultations;Core Facility;cost;Cryoelectron Microscopy;Cystic Fibrosis;Dedications;Development;Diabetes Mellitus;Disease;Disparate;diversity and inclusion;drug development;Drug Targeting;experience;Extramural Activities;Faculty;Faculty Recruitment;faculty research;faculty support;fascinate;Financial Support;forging;Fostering;Foundations;fundamental research;Funding;Future;Generations;Goals;Grant;Home;Image;Immunologics;Infection;Infrastructure;innovation;Institution;instrument;instrumentation;interest;Investigation;Investments;Ion Channel;knowledge translation;Malignant Neoplasms;Mass Spectrum Analysis;member;Membrane Fusion;Mentors;Metabolic Control;Microscope;Microscopy;mid-career faculty;Modeling;Molecular;molecular imaging;Molecular Target;Neoplasm Metastasis;new technology;novel therapeutic intervention;operation;Pathology;Phase;Play;Postdoctoral Fellow;pre-clinical;preclinical development;Production;Productivity;Program Reviews;programs;Protein Biochemistry;protein expression;Proteins;Recovery;recruit;Research;Research Institute;Research Personnel;Research Project Grants;Resources;Respiratory Tract Infections;Role;Schools;Scientist;Seasons;Series;Services;Signal Transduction;Subgroup;success;symposium;Targeted Research;Teacher Professional Development;Technology;Testing;Therapeutic;therapeutic target;Time;tool;translational goal;Translations;tumor progression;Vaccines;Virus Diseases;Work

PROJECT_TITLE: The Institute for Biomolecular Targeting - Lacefield Supplement


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: NEW ORLEANS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative Prepubescent children have historically been protected from the severe pulmonary pneumonias that have occurred during pandemic outbreaks of viruses such as influenza and Covid. We have identified a unique population of cells that we hypothesize are involved in this protection. The studies proposed here are designed to identify how these cells protect, in order to design therapies to reduce inflammation in non-protected populations.

PI_NAMEs: POCIASK, DEREK A (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: 1918 influenza pandemic;Adult;Age;Anti-Inflammatory Agents;Ants;Atrophic;CD4 Positive T Lymphocytes;Cell Separation;Cell Therapy;Cells;Child;COVID-19 outbreak;Cytoprotection;Data;design;Disease Outbreaks;Emigrant;Excision;Immunotherapy;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;Influenza;influenza infection;insight;Life;Lung;lung injury;migration;Modeling;mortality;Mus;Nature;novel;novel therapeutics;Output;pandemic disease;pandemic influenza;pandemic potential;Pathway interactions;Phenotype;Pneumonia;Population;Predisposition;Property;Pulmonary Inflammation;respiratory;Scientific Advances and Accomplishments;Testing;Therapeutic;therapy design;Thyme;Thymectomy;Thymus Gland;Time;Trachea;Viral;viral pandemic;Viral Pneumonia;Virus;Work

PROJECT_TITLE: Recent thyme emigrants mitigate viral pulmonary pneumonia

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: Project Narrative Increased wildfire activity and more firefighters means more occupational exposure, including to smoke. Reproductive risks are noted in the literature and highlighted by the fire service yet remain uncharacterized. We will characterize cross-season sperm quality changes and generate a strategic risk communication plan.

PI_NAMEs: MONTROSE, LUKE BENJAMIN (contact)

PROGRAM_OFFICER_NAME: GARRETT, BRIDGETTE E

PROJECT_TITLE: Understanding and Communicating Reproductive Health Consequences for Male Wildland Firefighters

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The restructured UCSF-Bay Area CFAR is dedicated to promoting multidisciplinary research addressing cutting-edge questions in HIV/AIDS biology, treatment, and prevention. This approach from UCSF has led to breakthrough discoveries advancing patient care and providing new approaches to curbing the HIV pandemic both locally and internationally. CFAR is also committed to supporting the next generation of HIV researchers, international research, health equity, and community engagement, all of which are critical for truly ending the HIV epidemic.

PI_NAMEs: GANDHI, MONICA  (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Advocacy;Area;Basic Science;Behavior;Behavioral Research;biobehavior;Bioinformatics;Biological Markers;Biological Specimen Banks;Biology;Biometry;career;career development;Cities;Clinic;Clinical;clinical care;Clinical Research;co-infection;cohort;Collaborations;Communication;Communities;community engagement;comorbidity;computerized data processing;Dedications;Development;Educational workshop;Epidemic;Evaluation;Event;experience;Fostering;Foundations;functional genomics;Goals;Grant;health equity;HIV;HIV/AIDS;Housing;Immunology;implementation science;improved;Inflammation;Infusion procedures;innovation;Institution;Interdisciplinary Study;International;intersectionality;Laboratories;Leadership;Measures;meetings;Mentors;Methods;minority investigator;Monitor;multidimensional data;multidisciplinary;Multiomic Data;Names;National Institute of Allergy and Infectious Disease;next generation;novel;novel strategies;Outcome;pandemic disease;Participant;Pathogenesis;Patient Care;Pharmacology;Positioning Attribute;pre-exposure prophylaxis;Prevention;Productivity;programs;Prospective cohort;referral services;Research;Research Personnel;Resources;response;Risk;social;Specimen Handling;structural determinants;structural health determinants;substance use;Training;Translational Research;Underrepresented Minority;United States National Institutes of Health;Visualization;Vulnerable Populations;ward;Work;working group

PROJECT_TITLE: UCSF-Bay Area Center for AIDS Research


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Cerebrovascular;Dementia;Lymphatic Research;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: MINNEAPOLIS

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Spreading depolarization is a slow-moving wave of abnormal electrical activity in the brain that occurs in many neurological conditions such as stroke. Recent experiments show that this phenomenon pulls cerebrospinal ﬂuid into the brain, killing additional brain cells, but the underlying mechanisms of this phenomenon are not understood. We will use simulations and mouse experiments to uncover the relative importance of three different likely mechanisms that lead to disruptions in the cerebrospinal ﬂuid ﬂow due to a spreading depolarization wave.

PI_NAMEs: TITHOF, JEFFREY  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Acute;Arteries;Astrocytes;Blood Vessels;Brain;brain cell;brain tissue;Calcium;Cell membrane;Cells;Cerebrospinal Fluid;cerebrospinal fluid flow;Chloride Ion;Classic Migraine;Couples;Coupling;Development;Diameter;Dimensions;Edema;Evolution;experience;experimental study;extracellular;Extracellular Space;fluid flow;glymphatic flow;glymphatic function;glymphatic system;Heart Arrest;Image;in vivo;insight;Intercellular Fluid;Ion Pumps;Ions;Ischemic Stroke;Link;Liquid substance;Maps;Measurement;Measures;Membrane;Modeling;Monitor;Mus;network models;Neurologic;Neurons;novel;Osmotic Pressure;particle;Physiological;Play;Potassium;potassium ion;Qualifying;Reporter;Resistance;Role;simulation;Sodium;sodium ion;Solid;spatiotemporal;Speed;Stroke;Swelling;Testing;Transgenic Mice;two photon microscopy;two-dimensional;two-photon;vasoconstriction;Vasodilation;Visualization;Water

PROJECT_TITLE: Experimentally-validated model of glymphatic disruption due to spreading depolarization

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research

ORG_CITY: Murray

ORG_NAME: IHC HEALTH SERVICES, INC.

ORG_STATE: UT

PHR: PROJECT NARRATIVE The Moana Project is dedicated to fostering community engagement and dialogue about genetic research within the Pacific Islander community. Our objective is to facilitate the formation of community-led best-practice guidelines and restrictions for future genetic research projects in this community.

PI_NAMEs: KNIGHT, STACEY  (contact)

PROGRAM_OFFICER_NAME: JOSE, SHEETHAL

PROJECT_TERMS: Arrhythmia;Asian;Attitude;Belief;Communities;community based participatory research;community consultation;community engagement;Community Health;Consent;Consultations;Contracts;Dedications;Development;Diagnostic;Disease;Early Diagnosis;Ensure;Ethics;ethnic disparity;Ethnic Population;European;Event;Extended Family;Feedback;Feeling;Fostering;Foundations;Future;Genes;Genetic;Genetic Databases;genetic information;Genetic Research;Genetic study;genetic testing;genetic variant;Goals;Guidelines;Health;Heritability;improved outcome;Individual;insight;Interview;Island;Long QT Syndrome;Malignant Neoplasms;Medical Genetics;meetings;Melanesian;member;mutual learning;Native Hawaiian;Oceans;Outcome;Pacific Islander;Pacific Islands;Patients;Pharmacologic Substance;Polynesian;Population;population based;Practice Guidelines;precision medicine;Principal Investigator;racial disparity;racial population;rare variant;Recording of previous events;Research Personnel;Research Project Grants;Review Literature;Samoan;Subgroup;targeted treatment;Test Result;Thinking;Tonga;Treatment outcome;Trust;Underrepresented Populations;Utah;Variant;variant of unknown significance;Voice;Work

PROJECT_TITLE: The Moana Project: The Connection Between Pacific Islanders and Genetics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SEIR-P (80)]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pain Research;Precision Medicine

ORG_CITY: IOWA CITY

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative This research addresses the pressing issue of underdiagnosed myofascial pain, which plays a significant role in various musculoskeletal pain conditions, including plantar fasciitis. By developing novel imaging biomarkers, this study aims to provide objective means of detecting myofascial pain, understanding its underlying mechanisms, and guiding personalized treatments. Given the high prevalence of plantar fasciitis and its long-lasting impact, this research has the potential to improve the diagnosis and treatment of not only this condition but also other lower extremity musculoskeletal disorders, ultimately enhancing public health by reducing illness and disability associated with chronic pain.

PI_NAMEs: CHIMENTI, RUTH LOUISE PORTER (contact);HOLMES, JAMES H;SLUKA, KATHLEEN A

PROGRAM_OFFICER_NAME: TUTTLE, ALEXANDER H

PROJECT_TERMS: Address;Adult;Affect;Aftercare;Anxiety;Biochemical;Biological Markers;biomarker validation;Biomechanics;biopsychosocial;biosignature;chronic pain;Cross-Sectional Studies;Data;data submission;Diagnosis;Diagnostic;diagnostic biomarker;diagnostic development;Diagnostic Imaging;disability;Dose;Double-Blind Method;Dryness;elastography;Enrollment;experience;Foot Pain;foot sole;Goals;Heel;High Prevalence;Image;imaging biomarker;Imaging Techniques;improved;improved outcome;Individual;individualized medicine;innovation;insight;Intervention;Knowledge;Location;Lower Extremity;Machine Learning;Magnetic Resonance Imaging;Massage;Measures;Mental Depression;Modeling;Monitor;Musculoskeletal;Musculoskeletal Diseases;Musculoskeletal Pain;Myofascial Pain Syndromes;Needles;non-invasive imaging;novel;novel imaging technique;Outcome;Outcome Measure;Pain;Pain Free;Pain intensity;Pain management;pain outcome;Participant;Patient Outcomes Assessments;personalized medicine;Phase;Plantar Fasciitis;Play;predictive marker;primary outcome;Procedures;prognostic;Property;Psychosocial Factor;Public Health;quantitative imaging;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research;Research Design;response;response biomarker;Role;Safety;Sample Size;Sampling;Severities;sex;soft tissue;standard care;Statistical Data Interpretation;targeted treatment;Tendinopathy;Testing;Tissues;tool;trial design;Ultrasonography;ultrasound

PROJECT_TITLE: Development of diagnostic and prognostic ultrasound imaging biomarkers for plantar heel pain

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 SH (14)]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Women's Health Research

ORG_CITY: JACKSON

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Our project addresses the critical need for improved treatments in Huntington's disease (HD), a devastating neurodegenerative disorder. We're developing GLYN122, a novel small molecule therapy, to lower mutant huntingtin protein (mHTT) levels and alleviate HD symptoms. As we investigate GLYN122's unique advantages and conduct a comprehensive analysis of sex-specific responses, our research aligns with the "Advancing Science for the Health of Women" initiative, and we will utilize the Molecular Center of Health and Disease (MCHD)-COBRE infrastructure to delve into the molecular and physiological mechanisms underpinning these sex-specific responses to GLYN122.

PI_NAMEs: GARRETT, MICHAEL R (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: Address;Administrative Supplement;Affect;Age;Apoptosis;Autophagocytosis;autosome;Behavior assessment;Binding;Biochemical;Biological Assay;blood-brain barrier crossing;blood-brain barrier penetration;Brain region;brain tissue;cell type;Centers of Research Excellence;Clinical;Complex;Corpus striatum structure;Disease;Disease Management;Disease Progression;Exhibits;experimental study;Female;Gender;Gene Expression;Gene Expression Profiling;Genes;Genetic;Genetic Diseases;Genetic Transcription;Goals;Hand Strength;Health;Health Sciences;Histologic;Hormonal;Huntington Disease;Huntington gene;Immunohistochemistry;Impairment;improved;in silico;In Situ Hybridization;In Vitro;in vivo;individualized medicine;Infrastructure;Inheritance Patterns;Inherited;innovation;insight;Intervention;Investigation;Light;male;Molecular;Molecular Target;Motor;motor deficit;motor disorder;motor symptom;mouse model;Mus;mutant;Mutation;Nerve Degeneration;Neurobehavioral Manifestations;Neurodegenerative Disorders;neuroinflammation;Neurons;neuropathology;novel;novel therapeutic intervention;Oxidative Stress;Pathogenesis;Performance;personalized therapeutic;Pharmaceutical Preparations;Physiological;polyglutamine;psychiatric symptom;reduce symptoms;Research;response;Role;Scanning;sex;Sex Differences;Shapes;single-cell RNA sequencing;small molecule;Spatial Distribution;Surface;Symptoms;Techniques;therapeutic candidate;Therapeutic Effect;Therapeutic Intervention;Tissue Sample;Transcriptional Regulation;transcriptomics;Treatment Efficacy;Weight;Weight Gain;Women's Health

PROJECT_TITLE: Molecular Center of Health and Disease


ADMINISTERING_IC: AG

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Diabetes;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SYRACUSE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: SYRACUSE UNIVERSITY

ORG_STATE: NY

PHR: This project provides a timely opportunity to explore and understand how cumulative precarity prior to and during a recession may have long-term consequences for health and survival disparities. As the remnants of the COVID-19 economic recession persist, with additional and disproportionate insults on both employment and health in Blacks, the full extent of which will not be fully understood for years to come, understanding prior cumulative effects will be important for addressing the effects of COVID-19 and future economic shocks. The study findings have great relevance for health and social policy aimed at building safety nets for vulnerable older workers approaching and preparing for retirement.

PI_NAMEs: MUTAMBUDZI, MIRIAM  (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Accounting;Address;Aging;Biological Markers;Black Populations;Black race;black women;black/white disparity;Blood Pressure;C-reactive protein;Cardiovascular Diseases;Categories;Cholesterol;COVID-19;COVID-19 impact;Data;Data Set;Deterioration;Diabetes Mellitus;Disadvantaged;Disease;Disparity;disparity reduction;Economic Recession;Economics;Employment;experience;Exposure to;Future;Gender;Glycosylated hemoglobin A;Growth;Health;Health and Retirement Study;health disparity;health inequalities;Health Policy;Hour;improved;Inequity;Information Networks;innovation;Interruption;Intervention;Knowledge;Link;Measures;mortality;Occupational;Occupations;older adult;Outcome;Patient Self-Report;Policies;poor health outcome;Population;population health;Probability;Process;programs;psychosocial;Psychosocial Assessment and Care;Public Health;Race;racial disparity;Recommendation;Recovery;Research;Research Priority;Retirement;Risk;safety net;Shapes;Shock;social;social health determinants;Social Policies;stem;structural health determinants;survival disparity;Time;trend;Unemployment;Wages;Woman;Work

PROJECT_TITLE: Cumulative Effects of Pre-recession and the Great Recession Precarity on Black-White Disparities in Health Biomarker Trajectories and All-cause Mortality Among Older Workers

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Rare Diseases;Vaccine Related

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Narrative Bordetella pertussis is the causative agent of pertussis or whooping cough. This research focuses on how Bordetella utilizes an effector delivery system that delivers an adhesin to eukaryote cells. This research will significantly increase our understanding of the evolution and virulence of some bacterial pathogens and could inform novel antimicrobial strategies.

PI_NAMEs: GONEN, SHANE ;GOULDING, CELIA  (contact);HAYES, CHRISTOPHER S.

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: 1 year old;Acellular Vaccines;Actins;Adherence;Adhesions;Anti-Bacterial Agents;antimicrobial;Architecture;Bacterial Adhesins;Bacterial Adhesion;Bacterial Proteins;Binding;Binding Proteins;Biochemical;Bordetella;Bordetella pertussis;C-terminal;Cell membrane;Cell surface;Cells;Cellular biology;Cilia;cilium motility;Complex;Cryoelectron Microscopy;Cytoplasm;Cytoskeleton;Cytosol;Dangerousness;Data;Dedications;Development;Distant;Enterobacter;Enterobacteriaceae;Epithelium;Eukaryota;Eukaryotic Cell;Evolution;Fortification;Growth;Health;Hemagglutinin;Heparin;Hospitalization;Human;improved;in silico;Incidence;infant infection;insight;Integrins;Investigation;Lactosylceramides;Mammalian Cell;Membrane;Microtubule-Associated Proteins;Microtubules;Modeling;Molecular;Newborn Infant;novel;Pathogenesis;pathogenic bacteria;Peptide Signal Sequences;Pertussis;Pertussis Vaccine;Protein Precursors;protein protein interaction;Protein Secretion;Proteins;Reporter;Research;Resolution;respiratory;Respiratory System;Ribonucleases;Role;stem;Structure;Sulfate;System;Testing;therapeutic development;Toxin;Vaccination;vaccine efficacy;Vaccines;Virulence;Virulence Factors;Work;Yersinia

PROJECT_TITLE: Investigation of the interaction of Bordetella FhaB adhesin with microtubules

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

ORG_STATE: MA

PHR: PROJECT NARRATIVE Genomic signatures provide insights into past mutational processes driven by DNA damage and repair, but they may not reflect the current status of DNA repair pathways in individual cells. A lack of functional assays has hampered efforts to understand the relationship between DNA repair and mutation signatures. We are therefore developing a high-throughput platform for measuring the activity of all major DNA repair pathways in hundreds of cell lines.

PI_NAMEs: HARADHVALA, NICHOLAS ;NAGEL, ZACHARY DAVID (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: advanced analytics;Aging;Bar Codes;Biological;Biological Assay;Cancer cell line;CCRL2 gene;Cell Cycle;Cell Line;Cells;Characteristics;Clonal Expansion;Communities;Data;Data Set;Dependence;Disease;DNA analysis;DNA biosynthesis;DNA Damage;DNA lesion;DNA Repair;DNA Repair Gene;DNA Repair Pathway;DNA Sequence Alteration;Drug Addiction;Encyclopedias;Epigenetic Process;epigenome;epigenomics;Etiology;Event;Experimental Models;experimental study;Fluorescence;functional status;Future;Gene Expression;Genes;Genome;genome integrity;genome sequencing;Genomic Instability;genomic signature;Genomics;Health;Heterogeneity;Human;immunodeficiency;Individual;insight;knockout gene;Lesion;Libraries;Link;Malignant Neoplasms;Measurement;Measures;Mismatch Repair;Mismatch Repair Deficiency;multiple omics;Mutation;Mutation Analysis;Nature;Nerve Degeneration;Nonhomologous DNA End Joining;Normal tissue morphology;novel;Nucleotide Excision Repair;Pathway interactions;Patients;Physiology;Plasmids;Premature aging syndrome;preservation;prevent;Process;Proteomics;Regulation;repaired;Replication Error;Reporter;Reporting;Resolution;Resources;screening;Signal Transduction;single-cell RNA sequencing;Site;Source;Specificity;Technology;Therapeutic;Tissue Model;tool;Transcript;transcriptome;transcriptomics;Transfection;translational potential;Variant;Work

PROJECT_TITLE: Integrating Genomic Signatures with Functional Analysis of DNA repair

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative The goal of this project is to utilize directed evolution to create a new enzyme to catalyze the oxidation of the most important inhibitory chemical signaling compound in the human brain, g-aminobutyric acid (GABA). With this new enzyme, microsensors to monitor GABA in the deep brain of laboratory animals can be constructed that will prove useful for the study of neurological disorders including Alzheimer’s disease, seizures and autism.

PI_NAMEs: MONBOUQUETTE, HAROLD GEORGE (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Achievement;Acids;Active Sites;Acute;Affect;Alzheimer's Disease;Amino Acids;Aminobutyric Acids;Anesthesia procedures;Area;autism spectrum disorder;Benchmarking;Binding;Biosensing Techniques;Biosensor;Bipolar Disorder;Brain;Calibration;Characteristics;Chemicals;Chemistry;Corpus striatum structure;crosslink;Data;density;detection limit;Development;Dimensions;Directed Molecular Evolution;Electrodes;Engineering;Environment;enzyme activity;Enzymes;Evolution;Exhibits;Fluorescence-Activated Cell Sorting;Future;gamma-Aminobutyric Acid;Generations;Glutamates;Goals;Human;Hydrogen Peroxide;Immobilization;Implant;improved;in vivo;in vivo evaluation;Induced Neurons;innovation;interest;Kinetics;Knowledge;Laboratories;Laboratory Animals;Liquid substance;Measures;meter;Microelectrodes;microsensor;millisecond;Miniaturization;Monitor;Mutagenesis;mutant;Nervous System Disorder;neural circuit;neurochemistry;Neurons;Neurosciences;neurotransmitter release;Neurotransmitters;Oxidases;oxidation;Performance;Persons;Procedures;Protein Engineering;Proteins;prototype;Publications;Publishing;Radial;Rattus;Reaction Time;Resolution;response;Schizophrenia;Seizures;sensor;Signal Transduction;Silicon;simulation;Site-Directed Mutagenesis;Structure;success;Techniques;Technology;Testing;Time;tool

PROJECT_TITLE: Engineered GABA oxidase for GABA sensing in vivo

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prostate Cancer;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE Tissue-based genomic analyses enabled by next-generation sequencing technologies have emerged to investigate race-specific somatic alterations and their clinical implications; however, tissue-based analyses are extremely challenging in metastatic prostate cancer because, as a bone-predominant metastatic disease, tissue samples are not always obtainable. In this proposed study, we aim to identify race-specific somatic mutations that are associated with survival disparity between black and white patients with metastatic prostate cancer, using a liquid biopsy approach based on circulation tumor cell sequencing to characterize and monitor tumor dynamics. The identified race-specific prognosis-relevant mutational signatures may assist in prognosis stratification, precision medicine, and optimal management of prostate cancer patients, including racial minorities who are underrepresented in previous molecular profiling studies.

PI_NAMEs: WANG, CHUN  (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: actionable mutation;Address;African;African American population;androgen independent prostate cancer;Applications Grants;Award;Biological Markers;Biopsy Specimen;black men;Black Populations;Black race;Blood;Blood specimen;bone;Cancer Burden;cancer health disparity;Cancer Patient;cancer survival;Cell Separation;Cells;Characteristics;Circulation;Clinical;clinical practice;cohort;Collecting Cell;cost effective;Data;Data Analyses;Death Rate;Detection;Development;Dimensions;Disease;Disease Progression;DNA Repair Gene;Ethnic Population;Evaluation;Exclusion;Exhibits;exome sequencing;follow-up;Future;Genetic;genomic aberrations;genomic biomarker;genomic profiles;genomic profiling;Genomics;Grant;Heritability;Heterogeneity;implementation barriers;Incidence;Inferior;Institution;Knowledge;liquid biopsy;Malignant neoplasm of prostate;Malignant Neoplasms;men;Metastatic Prostate Cancer;Molecular;molecular marker;Molecular Profiling;Monitor;mortality;mortality disparity;multi-ethnic;Mutation;Neighborhoods;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;next generation sequencing;novel;Oncogenic;Outcome;Patient-Focused Outcomes;Patients;Performance;Phenotype;Population Study;precision medicine;Primary Neoplasm;Prognosis;prognostic;prognostic significance;prospective;prostate biopsy;protein function;PTEN gene;Race;racial disparity;racial minority;racial population;Reporting;Research;Resolution;Resources;Sampling;single cell sequencing;single cell technology;Single Nucleotide Polymorphism;sociodemographics;Socioeconomic Factors;Somatic Mutation;Stratification;survival disparity;Taxonomy;Technology;therapeutic target;Time;Tissue Sample;Tissues;treatment response;tumor;tumor heterogeneity;United States;Variant;whole genome

PROJECT_TITLE: Circulating tumor cell profiling for genomic contributors to racial disparity in metastatic prostate cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-2 (M3)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE There is currently no therapy that can prevent the development of epilepsy after brain trauma. Here we propose to test the efficacy of a novel compound, and determine its efficacy and tolerability in an animal model of posttraumatic epilepsy, in a setting that resembles the clinical practice of care of people with severe traumatic brain injury. We also aim to identify and validate novel biomarkers that can predict who will develop epilepsy and who may respond to a treatment that can prevent epilepsy, in hope that this may accelerate and optimize future efforts to develop new antiepileptogenic therapies.

PI_NAMEs: AGOSTON, DENES V.;COLES, LISA D;DUNCAN, DOMINIQUE ;GALANOPOULOU, ARISTEA S (contact);MAZARATI, ANDREY M;O'BRIEN, TERENCE JOHN;STABA, RICHARD

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Acceleration;acquired epilepsy;Acute;Advisory Committees;Advocate;Anatomy;Animal Model;Anticonvulsants;Antiepileptogenic;Autophagocytosis;Axon;Bioinformatics;Biological Markers;biomarker discovery;biomarker identification;biomarker panel;biomarker selection;Blood;Blood Vessels;Brain;brain magnetic resonance imaging;Brain Pathology;Calcium-Binding Proteins;California;candidate marker;Caring;Cell Death;Cessation of life;Classification;Clinical;clinical practice;Collaborations;college;Corpus Callosum;Data;Deposition;design;Development;Discriminant Analysis;Disease;Double-Blind Method;early detection biomarkers;Early Post-Traumatic Seizures;Early treatment;efficacy testing;Electroencephalography;Epilepsy;Epileptogenesis;experience;External Capsule;fluid percussion injury;Free Radicals;functional outcomes;Funding;Future;Glial Fibrillary Acidic Protein;Guidelines;Health Services;Hemorrhage;High Frequency Oscillation;high standard;histological stains;HMGB1 gene;Image;improved;in vivo;Inflammatory;Injury;Interferon Type II;Interleukin-1 beta;International;Intervention;Investigation;Iron;Iron Chelation;Isoenzymes;Laboratories;Lateral;Learning;Levetiracetam;Link;Machine Learning;Magnetic Resonance Imaging;Medicine;Memory;Metabolic;Minnesota;Modeling;Modification;Molecular;Monitor;Motor;multimodality;National Institute of Neurological Disorders and Stroke;Neuroglia;neuroimaging;Neurons;novel;novel marker;Oxidative Stress;Pathologic;Pathology;Patients;Peripheral;Persons;pharmacokinetic model;Physiological;Plasma;Populations at Risk;Post-Traumatic Epilepsy;pre-clinical;Pre-Clinical Model;Preclinical Testing;predictive marker;Predictive Value;prevent;primary endpoint;Process;prophylactic;protein biomarkers;Randomized;Rattus;Recovery of Function;Research;Risk;Risk Factors;Seizures;Site;standard of care;synergism;tau Proteins;tau-1;Testing;Therapeutic;Time;Tissues;Translational Research;Traumatic Brain Injury;treatment response;ubiquitin C-terminal hydrolase;Universities;University Health Services;Visuospatial

PROJECT_TITLE: Translational Platform for Epilepsy Therapy and Biomarker Discovery


ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Nonresponse significantly undermines the representativeness of patient-reported outcome (PRO) data that is routinely collected as part of clinical care, thereby compromising its utility for facilitating high-value, equitable patient-centered care in cancer clinics. Using a multilevel framework and a mixed-methods approach, the proposed project strives to augment the understanding and management of nonresponse in PRO data collected as part of routine cancer care. This initiative will set the stage for harnessing pre-existing, routinely collected PRO data for equitable healthcare and quality improvement while also planning for future interventions aimed at expanding the reach of PRO data collection to underrepresented populations.

PI_NAMEs: LIU, JASON B;ZENG, CHENGBO  (contact)

PROGRAM_OFFICER_NAME: MITCHELL, SANDRA A

PROJECT_TERMS: Address;Affect;cancer care;Cancer Patient;cancer type;care delivery;Characteristics;Classification;Clinic;Clinical;clinical care;clinical practice;Collection;Continuity of Patient Care;Data;Data Collection;design;Development;Ensure;Equitable healthcare;Equity;ethnic minority;Evolution;Future;Geography;Goals;health care disparity;Healthcare;Healthcare Systems;Heterogeneity;implementation framework;improved;Information Systems;Infrastructure;innovation;insight;Integrated Health Care Systems;Intervention;Interview;Knowledge;Leadership;lens;Malignant Neoplasms;Massachusetts;Measurement;Measures;Methods;Minority Groups;Modification;novel;Outcome;Outcome Measure;patient oriented;Patient Outcomes Assessments;Patient Participation;patient population;Patient Representative;Patient-Centered Care;patient-clinician communication;Patients;Predisposition;Prevention strategy;programs;Protocols documentation;Provider;Quality of Care;racial minority;Radiation Oncology;randomized, clinical trials;Reporting;Research;Resources;response;routine care;shared decision making;Standardization;Structure;Symptoms;Testing;tool;Underrepresented Populations

PROJECT_TITLE: Nonresponse of Patient-reported Outcomes in Routine Cancer Care

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-2 (M2)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Dental, Oral, and Craniofacial Disease;Disability Research;Eye Disease and Disorders of Vision;Neurosciences;Rehabilitation

PHR: PROJECT NARRATIVE Facial paralysis can compromise control of the eyelids, leading to pain, discomfort, and loss of facial aesthetics. The state-of-the-art treatments that are intended to treat loss of eyelid function are not able to recapitulate the eyelid’s many behaviors, in part because it is not yet known how the human nervous system produces these behaviors. The objective of this project is to study the neurological mechanisms that underlie eyelid function in both healthy people and patients with facial paralysis, as a first step toward neuroprostheses that reproduce natural eyelid function to alleviate pain, protect the eye, and restore confidence.

PI_NAMEs: CLITES, TYLER R (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TITLE: ESTABLISHING THE NEUROPHYSIOLOGICAL BASIS FOR RESTORATION OF NATURAL BLINK

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The objectives of this project are to deepen our understanding of the molecular functions of the ubiquitin ligase Anaphase-Promoting Complex (APC) in inherited neurodevelopmental disorders. We previously identified key mechanisms by which APC-mediated ubiquitin signaling controls the composition of heterochromatin in neurons, and we are proposing sophisticated structural experiments to understand how ubiquitin ligases recognize substrates within protein complexes. These experiments will provide crucial molecular insight that hastens progress toward modulating key ubiquitin signaling pathways and/or their targets in order to therapeutically intervene in the pathogenesis of a class of debilitating diseases that represent a major unmet medical need.

PI_NAMEs: FERGUSON, COLE JOHN (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Address;Amino Acids;anaphase-promoting complex;aurora B kinase;Binding;Biochemical;Biological Assay;Biological Models;borealin;Brain;Cells;Chromatin;Chromosomes;Complex;Cryoelectron Microscopy;Data;Development;Disease;Enzymes;Evaluation;experimental study;Foundations;Genes;Goals;Heterochromatin;Histones;Human;Image;Impairment;In Vitro;in vivo;Inherited;inner centromere protein;insight;interest;Intervention;Knowledge;Lysine;Maps;Mass Spectrum Analysis;Mediating;Medical;Mitosis;Modernization;Molecular;Multiprotein Complexes;Mus;mutant;Mutant Strains Mice;Mutate;Nature;Nervous System Disorder;neurodevelopment;Neurodevelopmental Disorder;Neurons;Pathogenesis;Pathologic Processes;Pathology;Patients;Phosphorylation;Post-Translational Protein Processing;postmitotic;Process;protein complex;protein protein interaction;Proteins;Proteomics;Reaction;Recombinant Proteins;reconstitution;recruit;Regulation;Role;scaffold;Science;Serine;Signal Pathway;Signal Transduction;Societies;success;survivin;System;Therapeutic;therapeutic target;tool;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;Work

PROJECT_TITLE: Recognition and Ubiqutination of neurodevelopmental chromatin regulators


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Burden of Illness;Caregiving Research;Clinical Research;Dementia;Health Services;Neurodegenerative;Pain Research;Palliative Care

ORG_NAME: NATIONAL BUREAU OF ECONOMIC RESEARCH

PHR: OTHER PROJECT INFORMATION – Project Narrative How to care for Alzheimer’s Disease patients is a pressing public health question for which there have been few conclusive answers. This project aims to enhance our understanding of how hospice care, an increasingly prevalent end-of-life option chosen by over two-thirds of Medicare decedents with Alzheimer's, impacts the physical, psychological, and emotional well-being of both Alzheimer's patients and their family members.

PI_NAMEs: JI, YUNAN  (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Activities of Daily Living;Address;Admission activity;Affect;aggregation database;Alzheimer's Disease;Alzheimer's disease care;Alzheimer's disease patient;Analgesics;Area;beneficiary;Black race;Caregivers;Caring;Characteristics;Clinical assessments;Cognitive;comorbidity;County;Data;Data Set;Databases;Diabetes Mellitus;Drug Prescriptions;end of life;end of life care;experience;family burden;Family Caregiver;Family member;Family Study;Future;Health;health assessment;health care service utilization;Health Professional;Healthcare Market;Heart Diseases;Heterogeneity;Hispanic;Home;Hospice Care;hospice environment;hospice utilization;improved;Individual;informal caregiving;Inpatients;Institution;Intensive Care Units;large datasets;Link;loved ones;Measures;Medicare;Medicare claim;Mental Depression;Mental Health Services;Methodology;Methods;Mission;Names;Natural experiment;novel;Nursing Homes;Outcome;Outcome Assessment;Outpatients;Pain management;Pain Measurement;Patients;Personal Satisfaction;Persons;Pharmaceutical Preparations;Physicians;Policy Making;Population;Prevalence;psychologic;Public Health;Published Database;Quality of life;Research;Research Design;Research Personnel;response;Sampling;Selection Bias;Services;Shock;Surveys;Testing;trend;Visit;Well in self;Work

PROJECT_TITLE: The Impact of Hospice Care on the Wellbeing of Alzheimer's Disease Patients and Their Family Members

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Neurosciences;Substance Misuse

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF UTAH

PHR: ––– PROJECT NARRATIVE –––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––– Alcohol use disorders are a chronic human condition driven by numerous factors, including one’s initial sensitivity to ethanol intoxication, how easily one develops tolerance to these intoxicating effects with continued alcohol experience, or how one becomes insensitive to the pleasant, rewarding effects of alcohol over time. How exactly these different alcohol responses depend on each other has not been systematically analyzed. The results from this proposal will examine how these different alcohol responses depend on each other, thereby illuminating critical mechanisms driving addiction and substance use.

PI_NAMEs: ROTHENFLUH, ADRIAN  (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Acceleration;addiction;Address;Affect;alcohol behavior;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol exposure;alcohol response;alcohol sensitivity;alcohol use disorder;Alcoholic Intoxication;Alcohols;Automobile Driving;Behavior;Behavioral;behavioral outcome;Biological Assay;Brain;Chronic;Classification;Complex;Data;Development;Dose;Drosophila genus;Drug Kinetics;Ethanol;experience;experimental study;Factor Analysis;fly;Generations;Genes;Genetic;genetic approach;genetic manipulation;Goals;Grant;hedonic;Human;Individual;insight;interest;Intoxication;Label;Life;Mammals;Measures;Mediating;model organism;Modeling;Molecular;Motor;motor impairment;mutant;National Institute on Alcohol Abuse and Alcoholism;neuromechanism;neuronal circuitry;Neurons;Organism;pandemic disease;Pharmaceutical Preparations;Phase;Phenotype;pleasure;Positioning Attribute;predictive modeling;preference;Psychological reinforcement;Reaction;Research;Resistance;Rewards;Risk Factors;Rodent;Sedation procedure;Seizures;Self Administration;Stimulus;substance use;System;Testing;Time;tool;Tremor

PROJECT_TITLE: Alcohol Tolerance as a Driver of Self-Administration

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


NIH_SPENDING_CATS: Antimicrobial Resistance;Genetics;Infectious Diseases;Rare Diseases

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: NARRATIVE If successful, these studies would provide insights that could be leveraged therapeutically to develop “persistence inhibitors” that act cooperatively with traditional antibiotics to hasten Mabs eradication in patients.

PI_NAMEs: PENN, BENNETT  (contact)

PROGRAM_OFFICER_NAME: LAUGHON, BARBARA E

PROJECT_TERMS: Antibiotic Resistance;antibiotic tolerance;Antibiotics;Bacteria;Bacterial Infections;biological adaptation to stress;Cell Physiology;Cells;cytotoxicity;Data;deep sequencing;Defect;Development;experience;Exposure to;Foundations;Genes;Genetic;Genus Mycobacterium;Goals;Health;Immune system;Immunocompromised Host;improved;inhibitor;insight;Knowledge;Lysosomes;Mediator;Membrane;Microbe;multicatalytic endopeptidase complex;Mutagenesis;mutant;Mycobacterium abscessus;Mycobacterium Infections;non-tuberculosis mycobacteria;nutrient deprivation;older patient;Organism;oxidative damage;pathogen;Pathway interactions;patient population;Patient-Focused Outcomes;Patients;Peptide Hydrolases;Peptides;Phagocytes;Phenotype;Physiologic tolerance;Play;Probability;Process;Prokaryotic Cells;protein degradation;Proteins;Proteomics;Recurrence;Regulation;response;Role;sensor;Signal Transduction;Starvation;Stress;System;Testing;Therapeutic;therapy duration;Toxic effect;Ubiquitin;United States

PROJECT_TITLE: Regulation of antibiotic tolerance in Mycobacterium abscessus by proteolytic signaling

STUDY_SECTION: AIRT

STUDY_SECTION_NAME: Anti-Infective Resistance and Targets Study Section [AIRT]


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Development of potent and safe CRISPR tools for in vivo gene editing using directed evolution Research Narrative Though genome editing technologies provide therapeutic promise many diseases, the CRISPR sgRNA is prone to cellular instability and immunogenicity thus reducing clinical potential. Full chemical modification has been essential for the clinical success of past RNA therapeutics, but Cas9 does not function well with fully chemically modified sgRNA. In this proposal, we describe the development of fully-modified sgRNA:Cas9 pairs to improve in vivo stability and safety while enabling enhanced genome editing strategies, including self-delivering sgRNA, multiplexed targets, orthogonal sgRNA:Cas9 pairs, sgRNA redosing, transient editing, and vector inactivation.

PI_NAMEs: MILLER, SHANNON MARIE (contact)

PROGRAM_OFFICER_NAME: DARINGER, NICHOLE MARIE

PROJECT_TERMS: Adenosine;base editing;Base Pairing;Cell Culture Techniques;Cells;chemical synthesis;Chemicals;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR/Cas technology;delivery vehicle;Development;Directed Molecular Evolution;Disease;DNA;Dose;Electroporation;Emerging Technologies;Engineering;Eukaryotic Cell;Evolution;gene correction;Genes;Genetic Diseases;genome editing;Genomics;Guide RNA;Hematological Disease;hereditary blindness;Human;human disease;Immune Evasion;immunogenic;immunogenicity;improved;in vivo;inorganic phosphate;Length;Libraries;Malignant Neoplasms;Modification;Mutagenesis;Nerve Degeneration;Oligonucleotides;Patients;Proteins;Research;response;RNA;RNA Instability;RNA Interference;Safety;scaffold;Site;Specificity;success;Technology;Therapeutic;therapeutic RNA;tool;Toxic effect;uptake;Variant;vector;Vertebral column

STUDY_SECTION: CBP

STUDY_SECTION_NAME: Chemical Biology and Probes Study Section[CBP]


NIH_SPENDING_CATS: Aging;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BERKELEY

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE Survey methods for estimating adult mortality are critical in populations that lack complete death registration (including most of Africa and Asia), but current methods require large samples and rely on largely untested assumptions. The proposed research will analyze already-collected pilot data on new methods that require smaller samples; estimates will be compared to a gold standard for validation, and new qualitative data will be collected to help understand which methods perform the best. The results will produce tools that can improve measurement of adult mortality, and so improve science and policy around the world.

PI_NAMEs: FEEHAN, DENNIS MICHAEL (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Acquaintances;Acquired Immunodeficiency Syndrome;Adult;Africa;aging population;Asia;Bangladesh;Budgets;Cessation of life;Country;COVID-19;Data;Data Collection;Death Rate;design;Economic Policy;experience;experimental study;flexibility;Focus Groups;Future;Goals;Health;Health Policy;Household;improved;Income;informant;innovation;Interview;Learning;lens;Life Expectancy;low and middle-income countries;low income country;Measurement;Measures;member;Memory;Methods;mortality;Network-based;novel;pandemic disease;Persons;Policies;Population;Population Projection;Probability Samples;Qualifying;Questionnaires;Reporting;Research;Research Personnel;Respondent;Sample Size;Sampling;Science;Science Policy;Siblings;Site;Social Network;Social Policies;Source;Statistical Methods;Structure;Survey Methodology;Surveys;System;Testing;theories;Time;tool;Validation;web site

PROJECT_TITLE: Novel methods for estimating adult mortality using a survey

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ORG_CITY: HOUSTON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: RICE UNIVERSITY

ORG_STATE: TX

PHR: PROJECT NARRATIVE Infectious diseases cause an estimated 14.4 million deaths each year due to a lack of potent vaccines against some diseases (12.7 million deaths) as well as a lack of access to existing vaccines in low-resource settings (1.7 million deaths). Exponentially increasing the amount of antigen administered over time to mimic a natural infection has been shown to be an effective method for enhancing the immune response; however, the methods used to demonstrate this effect have consisted of infusion pumps or a series of tightly-spaced injections—both of which are infeasible to implement clinically. To employ this strategy in a clinically viable manner, we will develop formulations of modular biodegradable microparticles that, in combination, recapitulate the antigen kinetics of native infections to improve the efficacy of poorly immunogenic vaccines and/or truncate immunization schedules to enhance protection and increase vaccine assess.

PI_NAMEs: MCHUGH, KEVIN JAMES (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: adaptive immune response;Address;Adjuvant;Adsorption;Affinity;aluminum sulfate;Antibody titer measurement;Antigens;biodegradable polymer;Bolus Infusion;Cells;Cellular Immunity;Cessation of life;Clinic;Clinical;clinical practice;clinically relevant;Communicable Diseases;controlled release;copolymer;cost;cost effective;Diphtheria Toxoid;discrete time;Disease;Dose;Emulsions;Encapsulated;Engineering;Ensure;Event;Excipients;Exhibits;Exposure to;fabrication;Formulation;Glycolates;Hour;Human;Humoral Immunities;Immune;Immune response;Immune system;Immunity;Immunization Schedule;immunogenic;Immunologics;improved;In Vitro;in vivo;Infection;Infusion Pumps;Injections;Kinetics;Maintenance;Mediating;Medical;Methods;Modeling;Molecular Conformation;Molecular Weight;mortality;Mus;particle;pathogen;Pharmaceutical Preparations;Population;Preparation;Proteins;Pump;Recording of previous events;Research Personnel;Resource-limited setting;response;seal;Series;Signal Transduction;Societies;Solvents;System;T-Cell Activation;Testing;Time;Vaccination;vaccine delivery;vaccine development;vaccine formulation;Vaccines

PROJECT_TITLE: Improving Vaccination through Biomimicry: Recapitulating the Antigen Kinetics of Native Infections using a Modular Vaccine Delivery System

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


NIH_SPENDING_CATS: Biotechnology;Breastfeeding, Lactation and Breast Milk;Digestive Diseases;Foodborne Illness;Immunization;Infectious Diseases;Pediatric;Prevention;Vaccine Related;Women's Health Research

ORG_NAME: IMMPORT THERAPEUTICS, INC.

PHR: Humoral Immunity to Enteric Viruses among Infants and Mothers in Bangladesh Narrative Diarrhea is a leading cause of death among children under five years of age worldwide. This problem is particularly acute in low- and middle-income countries where access to clean water, vaccines and medical care may be limited. We will study antibodies produced by mothers and children that protect children from viral causes of diarrhea to identify the targets of protective antibodies which will be excellent potential vaccines in the future.

PI_NAMEs: CAMERINI, DAVID  (contact);HAQUE, DR. RASHIDUL ;PETRI, WILLIAM A

PROGRAM_OFFICER_NAME: FLORESE, RUTH HUAB

PROJECT_TERMS: 1 year old;5 year old;Acute;Adenoviruses;Antibodies;Antibody Repertoire;Antibody Specificity;antibody transfer;Antigens;Astrovirus;Bacteria;Bangladesh;Bangladeshi;Biological Assay;Caring;Cause of Death;Child;Childhood;Data;Development;Diarrhea;diarrheal disease;Ensure;Enteral;enteric adenovirus infection;Epitope Mapping;Foundations;Future;Gastroenteritis;Glycoproteins;Goals;Human;Human Milk;human pathogen;Humoral Immunities;Immune response;Immunity;Immunization;Immunoglobulin A;Immunoglobulin G;improved;Incidence;Income;Infant;Infant Health;Infection;Ingestion;Insecta;Life;low and middle-income countries;Mammalian Cell;maternal vaccination;Medical;Milk;Morbidity - disease rate;mortality;Mothers;Mucosal Immunity;neglect;Norovirus;novel;Passive Immunization;pathogenic virus;placental transfer;Postpartum Period;Prevention;Protein Fragment;Protein Microchips;Proteins;Protozoa;Rotavirus;Rotavirus Vaccines;Sampling;Sapovirus;Serum;tool;vaccine candidate;vaccine development;vaccine immunogenicity;Vaccine Research;Vaccines;Viral;Viral Proteins;Virus;Virus Diseases;Water

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Physical Injury - Accidents and Adverse Effects;Wound Healing and Care

ORG_CITY: GALVESTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: NARRATIVE Despite significant research and investment, no FDA approved broad spectrum countermeasures are available to rapidly mitigate vesicant-induced injury following intentional or accidental chemical exposure. A major limiting factor in the development of therapies is the lack of a comprehensive understanding of the inflammatory damage that occurs following cutaneous vesicant exposure. The goal of this proposal is to implement and establish a state-of-the-art spatial multi-omics platform to investigate conserved mechanisms of inflammatory damage induced by dermal exposure to sulfur mustard and lewisite vesicant classes in a clinically relevant porcine skin model.

PI_NAMEs: FINNERTY, CELESTE CAMPBELL;PRIDEAUX, BRENDAN  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Acute;Affect;Anti-Inflammatory Agents;Attention;Biopsy;Bulla;Burn injury;Cells;chemical accident;Chemical Exposure;Chemicals;Chronic;Cicatrix;clinically relevant;Cutaneous;cytokine;Data;Dermal;dermal exposure;Dermis;Development;Drug Delivery Systems;drug development;Drug Exposure;Eicosanoids;Ensure;Epidermis;Erythema;experience;Exposure to;Family suidae;FDA approved;Genetic Transcription;Goals;healing;Heterogeneity;Histologic;Hour;imaging approach;Immunohistochemistry;immunoregulation;In Situ;Infection;Inflammatory;Inflammatory Response;Injury;innovation;insight;Intervention;Investments;Lasers;Lesion;lewisite;lipid mediator;lipidomics;Lipids;Liquid substance;long-term sequelae;lung injury;Maps;mass spectrometric imaging;Mass Spectrum Analysis;medical countermeasure;Metabolic;metabolomics;Methods;Modeling;multiple omics;Mustard Gas;Necrosis;novel;Omega-3 Fatty Acids;Omega-6 Fatty Acids;Pathogenicity;Pathologic;Pathway interactions;Pharmaceutical Preparations;Phenotype;Play;Population;programs;promoter;Research;Resolution;response;Role;Skin;skin biopsy;skin damage;Skin injury;Spatial Distribution;spatial integration;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Structure;Subcutaneous Tissue;targeted treatment;Therapeutic Intervention;therapy development;Tissues;tool;transcriptomics;Vesicants;Visualization

PROJECT_TITLE: Integrated spatial omics to elucidate conserved inflammatory mechanisms of vesicant-induced skin injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-V (02)]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: EUGENE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: 8. PROJECT NARRATIVE The goals of this study are to culturally adapt the online version of the Family Check-Up and identify strategies to reduce barriers to engagement and support effectiveness through a community-engaged approach. We will integrate iterative feedback from a community advisory board into the adaptation of the online model. Our team will assess feasibility, accessibility, adoption, and potential effectiveness, with the goal of targeting key parenting mechanisms (parenting practices and cultural socialization) to reduce substance use risk among Latinx youth and inform broad public health efforts to prevent substance abuse.

PI_NAMEs: DOTY, JENNIFER L (contact)

PROGRAM_OFFICER_NAME: GOLDSTEIN, AMY B

PROJECT_TERMS: addiction;Address;Adolescent;adolescent substance use;Adoption;aged;arm;Behavior;behavioral outcome;Benchmarking;checkup examination;Child;Child Rearing;Clinical;Communities;community advisory board;community based participatory approach;community based research;community engaged approach;Community Health Aides;community research;community setting;Control Groups;coping;cost;County;Data;design;Development;Disease;Disparity;Effectiveness;effectiveness testing;eighth grade;Emotional;ethnic minority population;evidence base;Evidence based intervention;Evidence based program;experience;externalizing behavior;Face;Family;feasibility testing;Feedback;Goals;Growth;health disparity;Hybrids;implementation facilitators;implementation process;implementation strategy;implementation trial;Improve Access;improved;Intervention;Interview;junior high school;Latinx;Latinx population;Life;lifetime risk;marginalization;member;Methods;Middle School Student;Minority Groups;Modeling;National Institute of Drug Abuse;online delivery;online version;Oregon;Outcome;parenting intervention;Parents;Pilot Projects;Population;prevent;preventive intervention;primary outcome;Problem behavior;Process;programs;promote resilience;Provider;Public Health;racism;Randomized;Randomized, Controlled Trials;Recording of previous events;recruit;Reduce health disparities;reduced substance abuse;reduced substance use;Research;Research Personnel;resilience;Risk;Sampling;scale up;social health determinants;Socialization;socioeconomics;Source;Spanish;stressor;substance abuse prevention;substance use;Surface;Surveys;Symptoms;Translations;usability;Waiting Lists;Youth

PROJECT_TITLE: Adaptation of Family Check-Up Online in the Latinx Community to Reduce Youth Substance Use.

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PHR: PROJECT NARRATIVE Advances in deep learning and computer vision for surgical intelligence is currently limited by challenges to labelling large swathes of data from endoscopic video, which requires expert knowledge and high annotation costs. This project proposes a semi-autonomous pipeline for reduce drastically reducing the annotation cost for segmenting large sets of endoscopic videos by develop a robust set of learning-based approaches to data sorting and parsing and evaluating them on a cholorectal surgery dataset. The models developed for this pipeline would contribute to key knowledge about best practices for algorithms analyzing surgical video both during surgery and offline, for recommending assistance, noticing unsafe behavior, providing relevant semantic information, and disseminating key training materials, as examples.

PI_NAMEs: LIU, SHANGLEI ;YIP, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Active Learning;Address;algorithm training;Algorithms;Anatomy;Anterior;Area;Artificial Intelligence;automated algorithm;Awareness;Behavior;Clinical;Colorectal;Complex;Complication;Computer Vision Systems;cost;cost effective;Data;Data Scientist;Data Set;Data Storage and Retrieval;deep learning;Detection;Development;dexterity;Discipline;Dissection;Effectiveness;Erectile dysfunction;Excision;eye hand coordination;Feedback;Frequencies;Future;Hand;Health;Healthcare;Healthcare Systems;Image;image guided;improved;instrument;Intelligence;Knowledge;Label;Laparoscopic Surgical Procedures;large datasets;Learning;Left;Lighting;Machine Learning;Methodology;Methods;minimally invasive;Modeling;Modernization;Navigation System;Nerve;Network-based;neural network;Operative Surgical Procedures;Outcome;Pain;Patients;Perception;Performance;Phase;Prevention;Procedures;Recommendation;Recovery;Research;Resolution;risk prediction;Robotics;Safety;segmentation algorithm;self supervised learning;Semantics;Sorting;Surgical incisions;Surgical Instruments;System;Tactile;Technology;terabyte;Time;Tissues;Training;Treatment outcome;Work

PROJECT_TITLE: AI-assisted Annotation of Minimally Invasive Surgical Video for Building Information-Rich Datasets and Data-Efficient Learning Systems

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE A growing body of evidence suggests that in-utero experiences of housing insecurity are associated with an increased risk of adverse birth outcomes in low-income households . By reducing exposure to housing insecurity, prenatal housing assistance programs may play an important role in reducing the risk of adverse birth outcomes among low-income children. This study seeks to evaluate the impact of prenatal housing assistance on risk for adverse birth outcomes using quasi-experimental methods and a novel linkage of U.S. Department of Housing and Urban Development administrative records with California vital statistics birth records.

PI_NAMEs: THOMAS, KYLA  (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Address;adverse birth outcomes;Affect;Birth;Birth Certificates;Birth Records;Birth Weight;California;Cardiovascular Diseases;Categories;Child;Child Health;Childhood;Conceptions;cost;Country;Data;Data Set;Development;Disparity;Environment;Environmental Exposure;Equation;evidence base;experience;Exposure to;Family;Federal Government;Fetal Development;First Pregnancy Trimester;Food;Genetic Complementation Test;Government;Health;Health behavior;Health system;Healthcare;Heterogeneity;high risk;Household;Housing;housing instability;Impaired cognition;improved;in utero;Individual;Inequality;infant outcome;insight;Investments;Length;Link;Literature;Low Birth Weight Infant;Low income;Maternal Health;Measurement;Measures;Mediating;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;Mothers;Multiple Birth Offspring;Nature;Neighborhoods;neonatal health;Neurodevelopmental Impairment;Newborn Infant;novel;Observational Study;Outcome;Pathway interactions;Patient Self-Report;Persons;Play;Policies;Population;postnatal;Pregnancy;premature;Premature Birth;prenatal;Prenatal care;prenatal experience;prenatal exposure;prenatal stress;Preventive care;programs;Public Health;Public Housing;Quasi-experiment;Records;Research;Risk;Risk Reduction;Role;Second Pregnancy Trimester;Selection Bias;Small for Gestational Age Infant;social;Social Environment;social stress;Source;Special Supplemental Nutrition Program for Women, Infants, and Children;Stress;substance use;Third Pregnancy Trimester;Time;U.S. Department of Housing and Urban Development;United States;Vital Statistics;voucher;Waiting Lists;Weight Gain;Work

PROJECT_TITLE: Federal Housing Assistance and Birth Outcomes in the United States

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Health Services;Lung;Lung Cancer;Prevention;Primary Health Care

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: Project Narrative: Overdiagnosis of cancer generally causes the patient to engage in aggressive treatment and may result in anxiety, serious physical harm, unnecessary losses in quality of life, and financial health-care costs. Estimates of overdiagnosis in lung cancer due to population-based lung cancer screening have thus far only been estimated in randomized control trials, however, individuals participating in community-based screening programs are different from those participating in randomized control trials. This project will determine if overdiagnosis exists in lung cancer due to lung cancer screening and will estimate a range of overdiagnosis values.

PI_NAMEs: CARROLL, NIKKI  (contact)

PROGRAM_OFFICER_NAME: MARCUS, PAMELA M

PROJECT_TERMS: Age;aggressive therapy;Anxiety;Asthma;Bronchiectasis;Cancer Detection;cancer diagnosis;Caring;Cessation of life;Chronic Bronchitis;Chronic Obstructive Pulmonary Disease;Clinic;Clinical;cohort;Colorado;Communities;Community Health;Community Practice;community setting;comorbidity;Data;data modeling;Decision Making;Diabetes Mellitus;Diagnosis;Disease;Eligibility Determination;Equilibrium;follow-up;Future;Guidelines;Hawaii;Health;Health Care Costs;health care settings;Health Personnel;Health system;Healthcare Systems;Hypertension;Incidence;Individual;Lead;Left;life span;Longterm Follow-up;low dose computed tomography;Lung;lung basal segment;lung cancer screening;Malignant neoplasm of lung;Malignant Neoplasms;Modeling;Monitor;Morbidity - disease rate;mortality;mortality risk;novel;Observational Study;Outcome;Participant;Patient Participation;patient screening;Patients;Pennsylvania;Policies;Policy Maker;population based;Population Research;Process;Quality of life;Randomized, Controlled Trials;Recommendation;Reporting;Risk;Scanning;screening;Screening for cancer;screening participation;screening program;Smoke;Smoking;Smoking History;Smoking Status;Source;trend;Uncertainty;United States Preventative Services Task Force;Universities;uptake

PROJECT_TITLE: Estimating Overdiagnosis After Implementation of Lung Cancer Screening in Community-Based Healthcare Systems


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease

ORG_CITY: VANCOUVER

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY OF BRITISH COLUMBIA

ORG_STATE: BC

ORG_ZIPCODE: V6T 1Z3

PHR: 8. Project Narrative The purpose of the proposal is to develop a unique animal model, the leopard gecko, in which to study tooth development and loss. The adult leopard gecko, unlike mammals, has teeth that are replaced and shed throughout life and that can be directly accessed in order to expose the teeth to surgical procedures. The ability to stop and then restart tooth development in the gecko will one day be applicable to the bioengineering of human teeth and the prevention of tooth loss.

PI_NAMEs: RICHMAN, JOY M. (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Adult;Agonist;Alveolar;Animal Model;Animal Testing Alternatives;Animals;antagonist;Basement membrane;Behavior;Biological;biological development;Biological Response Modifier Therapy;Biomedical Engineering;Biomedical Research;Biophysics;Bite;Black Panther;bone;cathepsin K;cell type;Cells;Cementoclast;Cheek structure;Chemotactic Factors;Childhood;Clinical;CSF1 gene;Custom;Data;Defect;Degenerative polyarthritis;Dental;Dental Pulp;Dental Research;dental surgery;Dentistry;Dentists;Dentition;Development;Developmental Biology;Disease;Environment;Enzymes;Epithelium;Etiology;Excision;experience;Experimental Models;experimental study;Exposure to;Extracellular Matrix;Fishes;Generations;Genome;Goals;healing;Health;Human;Implant;in vivo;Injections;innovation;insight;Invaded;Investigation;Jaw;Life;Ligands;Location;Long-Term Effects;Malignant Bone Neoplasm;Mammals;mathematical analysis;Mathematical Biology;mathematical model;Mathematics;mature animal;Measures;Methods;Microscopic;migration;Modeling;Molecular;Monitor;Multipotent Stem Cells;Mus;novel;Operative Surgical Procedures;Oral;Oral cavity;Osteoclasts;Osteoporosis;Pathologic;Pathway interactions;Pattern;Periodicity;permanent tooth;Physiological Processes;Population;Positioning Attribute;Postdoctoral Fellow;premature;Prevention;Probability;Process;Proteins;PTHLH gene;Recording of previous events;recruit;Regenerative capacity;Reptiles;Research;Role;Root Resorption;Schedule;Semaphorins;Shark;Side;Signal Transduction;Specific qualifier value;Techniques;Testing;Time;Tissues;Tooth eruption;Tooth Germ;Tooth Loss;Tooth Migration;Tooth regeneration;Tooth Resorption;Tooth structure;Traction;transcriptome sequencing;Translating;Transplantation;treatment effect;Treatment Failure;Unerupted Tooth;Waxes;Work

PROJECT_TITLE: The adult leopard gecko, an emerging, unconventional experimental model for dental research

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Rare Diseases;Rett Syndrome;Women's Health Research

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: PROJECT NARRATIVE Emerging evidence shows that phenotypic alterations in neurodevelopmental disorders are caused by a multitude of factors, including altered interaction between neurons and astrocytes. This proposal asks how astrocyte-secreted Sema3c, upregulated in release from astrocytes in multiple neurodevelopmental disorders, mechanistically contributes to Rett syndrome pathology. Unbiased proteomics experiments will inform on how neuron-astrocyte communication is altered in Rett syndrome providing insights into dysregulated cellular interaction in vivo and identifying potential therapeutic targets.

PI_NAMEs: ALLEN, NICOLA J (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Address;Age;anxiety-like behavior;Astrocytes;Axon;axon guidance;Biotin;Body Weight;Brain;Breathing;candidate identification;Cell Communication;Cell Culture Techniques;Cell membrane;Cell Separation;cell type;Cells;Cognitive deficits;Communication;Data Set;Databases;Dendrites;Dendritic Spines;density;Development;Developmental Process;Disease;Down's Syndrome;Electrophysiology (science);Enzymes;Equilibrium;experimental study;Fragile X Syndrome;Functional disorder;Gene Expression;Gene Proteins;Genes;Goals;improved;In Vitro;in vivo;innovation;insight;intercellular communication;Label;loss of function mutation;Mass Spectrum Analysis;Mediating;Membrane;Membrane Proteins;Methyl-CpG-Binding Protein 2;Modeling;Molecular Genetics;Morphology;Motor;motor behavior;mouse model;Mus;Neonatal;Neurites;Neurodevelopmental Disorder;neuron development;neuronal survival;Neurons;Pathology;Phenotype;postnatal;Protein Secretion;Proteins;Proteomics;Research;restoration;Rett Syndrome;Role;Semaphorin-3;Signal Transduction;Synapses;synaptic function;synaptogenesis;Testing;therapeutic target;tool;transcriptome;Up-Regulation;Vertebral column;Weight Gain;Wild Type Mouse;Work

PROJECT_TITLE: Contribution of astrocytes to Rett syndrome

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Autoimmune Disease;Genetics;Human Genome;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Autoimmune disease affects 41 million Americans and rising. This genetic study focuses on discovering mutations in the protein coding region of the human genome that increase the risk for autoimmune disease, which are, by default, biological targets for treatment. The results from this study will enable better detection, prediction, and treatment for patients with autoimmune disorders.

PI_NAMEs: GERMAN, MICHAEL S (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Addison's disease;Adrenal Glands;Affect;American;Antigens;ATAC-seq;Autoantigens;Autoimmune;Autoimmune Diabetes;Autoimmune Diseases;Autoimmune Process;Autoimmunity;autoreactive T cell;autoreactivity;BHLH Protein;Biochemical;Biological;Biology;Cell surface;Cells;central tolerance;ChIP-seq;Circulation;Clinical;Code;Complex;Coupled;CRISPR/Cas technology;Detection;Development;Disease;DNA Sequence Alteration;Dominant-Negative Mutation;ES06;Etiology;Family;FOXP3 gene;Gene Expression;Generations;Genes;Genetic;genetic element;Genetic study;Genetic Transcription;Hela Cells;Human;human disease;Human Genome;Hypoparathyroidism;Hypothyroidism;Immune;Individual;insight;Insulin-Dependent Diabetes Mellitus;insulinoma associated 1;interest;Knock-in Mouse;Methods;Monogenic autoimmune disease;mouse model;Mutagenesis;Mutation;Mutation Detection;nerve stem cell;Neuroendocrine Cell;novel;Open Reading Frames;Organ;Pancreas;Pathway interactions;patient registry;Patients;peripheral lymphoid organ;Phenotype;Population;Positioning Attribute;prevent;Process;Proliferating;promoter;Proteins;Regulator Genes;Regulatory T-Lymphocyte;Reporting;Risk;Role;Severities;Siblings;single-cell RNA sequencing;Specific qualifier value;System;T-Lymphocyte;Tertiary Protein Structure;Testing;Thymic epithelial cell;Thymus Gland;Tissues;Transactivation;Transcription Coactivator;transcription factor;transcriptome sequencing

PROJECT_TITLE: Role of the bHLH Transcription Factor ASCL1 in Central Tolerance

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Aging;Biotechnology

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative As the global population ages, addressing aging-related musculoskeletal disorders gains importance. To prepare scientists for diverse post-training career prospects beyond academia, the Aging Research and Entrepreneurial Development Immersion (A-REDI) R25 proposal aims to provide training in aging research and various career paths through didactic training and an immersive period, supported by experts in regulation, law, and entrepreneurship. The program's goals encompass comprehensive training, practical experience, communication skills, and fostering collaboration in an interdisciplinary environment, empowering trainees to translate their research and explore careers in aging innovation.

PI_NAMEs: FREEDMAN, BENJAMIN ROSS (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-I (M2)]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Obesity;Osteoporosis;Women's Health Research

ORG_CITY: PORTLAND

ORG_NAME: MAINEHEALTH

ORG_STATE: ME

PHR: Narrative This application requests Phase II support for a successful COBRE in Mesenchymal and Neural Regulation of Metabolic Networks. Three new diverse projects study thermogenic adipocytes, gut-bone interactions, and impact of night shift work on diabetes risk in pregnancy, and they will contribute to our knowledge about how to better treat chronic metabolic diseases. Core facilities provide support for Physiology, Histopathology and Microscopy, and Proteomics and Lipidomics.

PI_NAMEs: LIAW, LUCY  (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: Achievement;acute care;Adipocytes;Adipose tissue;Advisory Committees;Age;Area;arm;Award;bariatric surgery;base;Basic Science;Biochemical Pathway;Biology;Biomedical Research;bone;bone loss;Bone Marrow;Cardiovascular system;career development;Career Mobility;Caregivers;Caring;Centers of Research Excellence;Chronic;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communities;Complement;Core Facility;Country;Data Analyses;Data Analytics;Development;Diabetes Mellitus;diabetes risk;Disease;diversity and inclusion;Doctor of Philosophy;doctoral student;Education;Equipment;equity, diversity, and inclusion;Experimental Designs;Faculty;Faculty Recruitment;Feedback;Fellowship;Female;Fostering;Foundations;Funding;Goals;Grant;Growth;Health;Healthcare;Histopathology;Hospitals;improved;Inflammatory;Infrastructure;Institution;instrumentation;interest;Investments;Knowledge;Lead;Leadership;lipidomics;Maine;Medical center;member;Mentors;Mentorship;Mesenchymal;Metabolic;Metabolic Diseases;Metabolism;Microscopy;Mission;model development;Modeling;Morbidity - disease rate;mortality;neural;neuroregulation;New England;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Osteoporosis;Outcome;Pain;Patient Care;Performance;pharmacologic;Phase;Physiology;Pilot Projects;Policies;population health;Population Research;Predisposition;Pregnancy;Pregnant Women;Principal Investigator;Productivity;Professional Education;professor;Program Evaluation;programs;Proteomics;Public Health;recruit;reproductive;Request for Applications;Research;Research Institute;Research Personnel;Research Project Grants;Resource Sharing;Resources;responsible research conduct;rural disparities;Scientist;Sensory;Services;shift work;Signal Transduction;skeletal;Smooth Muscle;student mentoring;Student recruitment;success;synergism;Talents;Technology;Time;Tissues;Training;Training and Education;Translational Research;United States National Institutes of Health;Universities;Update;Woman;Work

PROJECT_TITLE: Female Long-term Adverse Metabolic Effects (FLAME): Inflammatory health outcomes of gestational and type 2 diabetes in reproductive-age women


ADMINISTERING_IC: IP

IC_NAME: NATIONAL CENTER FOR IMMUNIZATION AND RESPIRATORY DISEASES

ORG_CITY: PITTSBURGH

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative- Component A  We propose a study among patients requesting medical care for respiratory virus symptoms to determine influenza and COVID-19 vaccine effectiveness by comparing vaccine histories of participants who test positive for influenza or COVID-19 to those who test negative for influenza or COVID-19. We aim to enroll 1000-1200 outpatients during the influenza season in age groups 6 mos-18 years, 19-49 years, and ≥50 years, plus remote enrollment outside of influenza season (another 400-900 if COVID-19 persists). We will genetically sequence specimens for virus types (clades) and determine the annual, population-based burden of influenza and COVID-19 for Allegheny County (Pittsburgh) from the UPMC Health Plan.

PI_NAMEs: ZIMMERMAN, RICHARD K (contact)

PROJECT_TITLE: RFA-IP-22-004, Evaluating respiratory virus vaccine effectiveness in a large, diverse healthcare system


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Diabetes;Digestive Diseases;Liver Disease;Microbiome;Nutrition

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Non-alcoholic fatty liver disease (NAFLD) is the most-prevalent chronic liver disease worldwide and can progress to cirrhosis and liver cancer, but has no approved pharmaceutical treatments. The proposed studies are relevant to the mission of the NIDDK because they will identify novel mechanisms by which the gut microbiome regulates hepatic gluconeogenesis in states of health and obesity-related metabolic disorders. The proposed research is relevant to public health because it will determine specific gut microbes and microbially-derived metabolites that regulate hepatic gluconeogenesis, with the goal of identifying new pharmacotherapeutic approaches to the management of NAFLD.

PI_NAMEs: KRISKO, TIBOR  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Advisory Committees;Amino Acids;Bioinformatics;Biological Assay;blood glucose regulation;career development;Chronic;chronic liver disease;Circulation;Cirrhosis;Citric Acid Cycle;Clinical;Complex Mixtures;Data;Development Plans;Diet;Disease;dysbiosis;Engineering;Equilibrium;euglycemia;experimental study;Feces;genome sequencing;Gluconeogenesis;Glucose;glucose metabolism;glucose production;Goals;gut microbes;gut microbiome;gut microbiota;gut-liver axis;Health;Hepatic;hepatic gluconeogenesis;Hepatocyte;Homeostasis;host-microbe interactions;Human;Human body;Human Microbiome;Hyperglycemia;Hyperglycemic Mice;In Vitro;in vivo;Institution;Investigation;K-Series Research Career Programs;Liver;liver metabolism;Malignant neoplasm of liver;medical schools;Memorial Sloan-Kettering Cancer Center;Mentors;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolism;metabolomics;Microbe;microbial;Microbial Genome Sequencing;microbiome;microbiota;Mission;Molecular;mouse model;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;non-alcoholic fatty liver disease;novel;Nutrient;Obesity;Outcome;Pathogenesis;Pathologic;Pathway interactions;Patients;Pharmacologic Substance;Play;Portal vein structure;Process;Production;programs;Public Health;Publishing;Regulation;Research;Research Personnel;Research Project Grants;Role;Scientist;Serum;Testing;Therapeutic;Transplantation;Tricarboxylic Acids;Universities;Volatile Fatty Acids;western diet;whole genome;Work

PROJECT_TITLE: Leveraging the Gut Microbiome to Regulate Hepatic Gluconeogenesis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

PHR: In response to concerns about access to and quality of care at VA facilities, the VA has begun to redirect resources toward financing care for Veterans outside of the VA. However, the quality and cost of care for Veterans that will result from this “make-or-buy” decision remain a scientific unknown. We will evaluate this question in emergency department (ED) care, using natural experiments that quasi-randomly assign Veterans to VA versus non-VA EDs. In our preliminary work, we have found that VA EDs reduce elderly Veteran mortality by 50%, or 5 percentage points. We will estimate the effects of VA versus non-VA ED care on health outcomes, process measures, and cost. We will further assess factors that influence these outcomes and evaluate mechanisms modifying the effect, such as staffing and care coordination. This research will help guide policymakers to optimally direct resources toward VA or non-VA care, and to tailor choices regarding non-VA contracting or VA investment to local conditions, with the goal of maximizing Veteran health outcomes.

PI_NAMEs: CHAN, DAVID CHIMIN (contact)

PROJECT_TERMS: Accident and Emergency department;Address;Adopted;Affect;Age;Ambulances;Board Certification;care coordination;care costs;Caring;Characteristics;Community Healthcare;comorbidity;complex chronic conditions;Contracts;cost;cost outcomes;Data;Decision Making;demographics;Diagnosis;Direct Costs;Economics;Elderly;Emergency Care;Emergency department visit;Emergency medical service;Emergency Medicine;Emergency Situation;Face;Goals;Guidelines;Health;health care delivery;health difference;Health Services Accessibility;Homelessness;improved;Intervention;Investments;Knowledge;Link;Literature;Location;low socioeconomic status;Maps;Mediating;Mental Health;Methods;mortality;Natural experiment;Newly Diagnosed;Outcome;Outpatients;Patients;Physicians;Play;Policies;policy implication;Policy Maker;prevent;Process Measure;Provider;Quality of Care;Quasi-experiment;Randomized;randomized trial;Records;Research;residence;Resources;response;Site;Source;Teaching Hospitals;Testing;Trauma;Traumatic Brain Injury;Triage;Variant;Veterans;Work

PROJECT_TITLE: Evaluating the VA Make-or-Buy Decision in Emergency Care

STUDY_SECTION_NAME: HSR-5 Health Care System Organization and Delivery and Women's Health[HSR5]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: KALAMAZOO

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: WESTERN MICHIGAN UNIV SCHOOL OF MEDICINE

ORG_STATE: MI

PHR: Project Narrative  In 2021, an estimated 391,827 pediatric patients treated by emergency medical services personnel received an incorrect drug dose, with many suffering adverse drug events. Previous strategies and developed tools have failed to have a significant impact on this issue due to their failure to address the many common causes of error with pediatric medication administration in emergency medical services and failure to rigorously design and test solutions. Using a multidisciplinary team and a comprehensive design thinking process, we will develop and test a highly dynamic cognitive aid application for use through a head-mounted display to dramatically decrease pediatric medication errors in emergency medical services.

PI_NAMEs: HOYLE, JOHN D (contact)

PROGRAM_OFFICER_NAME: RODRICK, DAVID

PROJECT_TITLE: Augmenting the On-scene Medic (ATOM): Development of a head-mounted display application to reduce prehospital pediatric medication errors

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


PHR: Improving access to high-quality care is a top priority for VHA, and the Veterans Choice Program (VCP) and MISSION Act are intended to increase Veteran access to care. However, access is difficult to measure, and correlational studies are prone to unobserved confounders. Our study leverages natural experiments, in the form of arbitrary administrative rules, that enable Veterans to access care outside VHA in the forms of Medicare and VA Community Care (VACC). We apply novel econometric techniques to identify a new measure of access and find the causal effects of increasing access on Veteran health care utilization and outcomes. Using linked VA and non-VA care data from CY 2007-2017, our results will show gaps in VHA services as well as the causal effect of expanded access for Veterans. The findings from this research will provide crucial information that VA must have to effectively implement the MISSION Act and provide high-quality care to Veterans.

PI_NAMEs: WAGNER, TODD H (contact)

PROJECT_TERMS: Affect;Age;Automobile Driving;Budgets;Caring;Censuses;Communities;Community Healthcare;Correlation Studies;Data;design;Diagnosis;Disease;econometrics;Elderly;Eligibility Determination;Ensure;Etiology;evidence base;Evolution;Future;gaps in access;General Population;Health;health care availability;health care service utilization;Health Insurance;Health Personnel;Health Services Accessibility;Health Services Research;Healthcare;Healthcare Systems;human old age (65+);Improve Access;improved;Individual;innovation;Insurance Coverage;Investments;Link;Location;Machine Learning;Measures;Medicare;Methodology;Methods;mortality;Natural experiment;novel;Outcome;Patients;Persons;Policies;Prevalence;Privatization;Procedures;programs;Provider;Publishing;Quality of Care;randomized, clinical trials;Records;Research;Research Methodology;satisfaction;Seminal;Services;Subgroup;Surveys;System;Techniques;Testing;Time;treatment effect;Veterans;Wait Time;Work

PROJECT_TITLE: Utilization and Health Outcomes for Veterans with Expanded Health Care Accessâ¯


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention

ORG_CITY: CORAL GABLES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Narrative – Miami Center for AIDS Research The Miami Center for AIDS Research (CFAR) at the University of Miami Miller School of Medicine is applying for funding for 5 more years, representing a 4th renewal cycle. It is the only CFAR in Florida, a state with the highest rate of new infections in the U.S., and Miami is the epicenter of the HIV/AIDS epidemic, underscoring the need for a CFAR. The mission of the Miami CFAR is to advance HIV/AIDS research by providing scientific leadership and developing an infrastructure that fosters integration of basic, clinical, and behavioral/social sciences, promotes education and mentorship, and partners with the community and Florida Department of Health to prevent, treat and cure HIV/AIDS, ultimately to end the HIV epidemic.

PI_NAMEs: PAHWA, SAVITA  (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Academy;Achievement;Acquired Immunodeficiency Syndrome;acronyms;Administrative Supplement;Advisory Committees;Affect;African American population;Aging;AIDS related cancer;Area;Award;base;behavioral and social science;biobehavior;Cancer Center;career development;Career Mobility;Child;Clinical;Clinical Sciences;Cohort Studies;Collaborations;Communicable Diseases;Communities;community advisory board;community engagement;Community Outreach;County;Dedications;Development;Doctor of Philosophy;Education;Elements;Emerging Communicable Diseases;Epidemic;Event;experience;Faculty;Faculty Recruitment;Federally Qualified Health Center;Florida;Fostering;Funding;Geography;Goals;Grant;Growth;Health;Health equity research;HIV;HIV diagnosis;HIV/AIDS;Hospitals;Immune response;Immunotherapy;improved;Individual;Industry;Infection;Inflammation;Infrastructure;Injecting drug user;innovation;Institution;Interest Group;International;Knowledge;Laboratories;Latino;Latinx;Leadership;Lesbian Gay Bisexual Transgender Queer;Life;Link;Malignant Neoplasms;medical schools;men who have sex with men;Mental Health;Mentors;Mentorship;Metabolism;Minority;Mission;National Institute of Mental Health;Needle-Exchange Programs;Needs Assessment;Neurosciences;next generation;novel;perinatal HIV;Persons;Play;Policies;Positioning Attribute;pre-exposure prophylaxis;prevent;programs;recruit;reproductive outcome;Research;Research Personnel;Resource Allocation;Resources;Role;Science;Shapes;Strategic Planning;success;synergism;The Multicenter AIDS Cohort Study;tool;Translational Research;transmission process;Treatment outcome;United States National Institutes of Health;Universities;Woman;Women's Interagency HIV Study;working group

PROJECT_TITLE: Miami Center for AIDS Research


NIH_SPENDING_CATS: Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases

ORG_CITY: PROVIDENCE

ORG_NAME: MIRIAM HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE The Providence/Boston CFAR (Prov/Bos CFAR) is a collaboration between Lifespan/Brown University and Boston University/Boston University Medical Center leveraging our complementary and synergistic strengths to build a multidisciplinary HIV research portfolio. Our CFAR is particularly focused on marginalized populations including men who have sex with men (MSM), people who use substances, justice-involved persons, women, gender minorities, and at-risk youth both domestically and globally. The resources of the CFAR have resulted in an increase in our HIV funding, increased hiring of new faculty engaged in HIV research, and support for early stage investigators to develop a career in HIV research.

PI_NAMEs: CU-UVIN, SUSAN  (contact)

PROGRAM_OFFICER_NAME: SCHOONMAKER, ANNALISE ROSA

PROJECT_TERMS: Academic Medical Centers;Acquired Immunodeficiency Syndrome;Address;Area;Arkansas;Award;base;Basic Science;Behavioral;Behavioral Sciences;Biometry;Boston;career;Clinical;Clinical Sciences;co-infection;Collaborations;Communication;Communities;community collaboration;community engaged research;community engagement;community organizations;comorbidity;Continuity of Patient Care;Development;Discipline;Education;Educational workshop;Ensure;Epidemic;equity, diversity, and inclusion;Faculty;Funding;Future;gender minority;Goals;Grant;Health;HIV;HIV/AIDS;Immunology;improved;Incidence;innovation;Institution;International;Intervention;Justice;Kenya;Knowledge;Laboratories;Leadership;Learning;Life Cycle Stages;life span;marginalized population;Massachusetts;Medical center;member;men who have sex with men;Mentors;Microbiology;Mississippi;multidisciplinary;New England;next generation;novel;Oral health;outreach;Performance;Persons;Philippines;programs;Public Health;Research;Research Personnel;Research Support;Resources;Rhode Island;Risk;Services;Site;social media;South Africa;Speed;Strategic Planning;substance use;summer internship;Tennessee;Translational Research;Uganda;Ukraine;Underrepresented Minority;United States;United States National Institutes of Health;Universities;virology;Woman;working group;Youth;Zambia

PROJECT_TITLE: Providence/Boston Center for AIDS Research (CFAR)


ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative The “Rustbelt” Center for AIDS Research (CFAR) joins Case-Western University and the University of Pittsburgh to create a regional center focused on ending the HIV epidemic through expanded and innovative research on curing HIV, differences in men and women’s responses to infection and treatment and the development of strategies to prevent new infections while effectively preventing AIDS.

PI_NAMEs: HILLIER, SHARON L.;KARN, JONATHAN  (contact)

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Africa South of the Sahara;AIDS prevention;Area;base;Basic Science;Bioinformatics;Biological Assay;biological sex;Biostatistics Core;career;Clinical;Clinical Investigator;Clinical Research;Clinical Sciences;Clinical Trials;Clinical Virology;cohort;Collaborations;Communities;community engagement;Community Outreach;comorbidity;County;design;Development;Direct Costs;Education;Epidemic;epidemic preparedness;Ethical Issues;experience;Faculty;faculty support;Foundations;Funding;Gender;Grant;HIV;HIV drug resistance;HIV Infections;HIV/AIDS;Income;Infection;innovation;Institution;interdisciplinary collaboration;International;Investments;Joints;Laboratories;Leadership;Link;member;men;Mentors;Monitor;multidisciplinary;next generation;novel strategies;Participant;Pathogenesis;Pilot Projects;Positioning Attribute;prevent;Prevention;Prevention Research;Prevention trial;Process;programs;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;research study;response;Role;Scientific Advances and Accomplishments;Services;sex;Site;Specimen;Strategic Planning;synergism;Systems Biology;Teacher Professional Development;Technology;Tissue Microarray;Training;Translating;Translational Research;treatment trial;Uganda;United States National Institutes of Health;Universities;University Hospitals;vaccine trial;Viral Pathogenesis;virology;Woman;Work;working group

PROJECT_TITLE: Rustbelt Center for AIDS Research (Case/UHC-Pitt CFAR)


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Infectious Diseases;Prevention