NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Social Determinants of Health

PHR: PROJECT NARRATIVE: DIEHL PROJECT Not applicable. See Overall plan.

PI_NAMEs: DIEHL, MARIA MAGDALENA (contact)

PROJECT_TERMS: Affect;Anterior;Anxiety Disorders;avoidance behavior;Behavior;Behavioral;brain control;cingulate cortex;clinically relevant;Cognitive;Complex;Computer Models;conditioned fear;conditioning;Cues;Dangerousness;Data;Electrophysiology (science);emotional trauma;Exhibits;experience;Freezing;Fright;Goals;Human;Impairment;in vivo;Individual;insight;interest;Knowledge;Learning;Measures;Mediating;Memory;Mission;neural circuit;neural correlate;Neurobiology;neuromechanism;Neuronal Plasticity;Neurons;neuropsychiatric disorder;neuroregulation;novel;optogenetics;Output;Persons;Phase;Post-Traumatic Stress Disorders;Prefrontal Cortex;prevent;promote resilience;Rattus;Research;response;Rodent;Shock;Signal Transduction;social;Social Conditions;Social Interaction;social learning;Social support;Stress;Testing;therapy development;Trauma;Work

PROJECT_TITLE: Prefrontal circuits of active avoidance under social conditions in rats


ADMINISTERING_IC: NS

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Schizophrenia

ORG_CITY: COLD SPRING HARBOR

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: COLD SPRING HARBOR LABORATORY

ORG_STATE: NY

PHR: The central goal of this proposal is to disseminate MAPseq and BARseq to the broader neuroscience community. The dissemination of these high-throughput methods for determining neuronal projections will enable many laboratories to use these methods to understand normal neuronal circuitry, and how this circuitry is disrupted in animal models of neuropsychiatric disorders like autism and schizophrenia.

PI_NAMEs: ZADOR, ANTHONY M (contact)

PROGRAM_OFFICER_NAME: TRZCINSKI, NATALIE KATHERINE

PROJECT_TERMS: Acceleration;addiction;Age;anatomical tracing;Animal Model;Animals;Area;Atlases;autism spectrum disorder;Axon;Bar Codes;bioinformatics pipeline;Biological Models;Brain;Brain Mapping;Brain region;brain tissue;Carrier Proteins;Collaborations;Communities;Complex;Computer software;cost;Data;Dedications;Development;Distant;DNA sequencing;Engineering;Foundations;Gender;Gene Expression;Generations;Genes;Genetic Models;Gilles de la Tourette syndrome;Goals;High-Throughput DNA Sequencing;In Situ;in situ sequencing;Infection;insight;interest;Interneurons;Label;Laboratories;Libraries;Maps;Mental Depression;Methods;Multiplexed Analysis of Projections by Sequencing;Mus;Neocortex;neural;Neuroanatomy;Neurofibrillary Tangles;neuronal circuitry;Neurons;Neuropil;neuropsychiatric disorder;Neurosciences;Neurosciences Research;neurotransmission;next generation;next generation sequencing;novel;novel strategies;Population;Presynaptic Terminals;Probability;Protocols documentation;Publications;Publishing;Reagent;Resolution;Reverse Transcription;RNA;Role;Schizophrenia;Scientist;skills;Specificity;Standardization;Synapses;Techniques;Technology;Time;tissue processing;Training and Education;transcriptomics;user-friendly;Viral;Virus;Virus Replication;Vision;Work

PROJECT_TITLE: Dissemination of MAPseq and BARseq for High-Throughput Brain Mapping


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Dementia;Neurodegenerative;Neurosciences;Nutrition;Physical Activity;Prevention

ORG_CITY: MANHATTAN

ORG_NAME: KANSAS STATE UNIVERSITY

ORG_STATE: KS

PHR: PROJECT NARRATIVE: HALL PROJECT Not applicable. See Overall plan.

PI_NAMEs: HALL, STEPHANIE E (contact)

PROJECT_TERMS: abeta accumulation;Affect;age related;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease therapy;American;Amyloid beta-Protein;Animal Disease Models;Animal Diseases;Animal Model;Antioxidants;Apoptosis;Autophagocytosis;Behavior;behavior influence;Behavioral;behavioral outcome;Brain;brain health;Brain Pathology;Caloric Restriction;Cause of Death;Cells;Cerebrum;Cognitive;Computer Models;cost;Diagnosis;diet and exercise;dietary restriction;Disease;Energy Intake;Exercise;hyperphosphorylated tau;Impaired cognition;improved;Inflammation;inflammatory marker;innovation;interest;Intermittent fasting;Intervention;Learning;Link;Literature;Measurement;Measures;Memory;Methods;Mission;Modeling;Molecular;Muscle;Neurobiology;Neurofibrillary Tangles;neurogenesis;neuron loss;Neuronal Plasticity;Neurons;neuroprotection;neuroregulation;novel;older adult;oxidative damage;Oxidative Stress;Pathologic;Patient Compliance;Pharmacologic Substance;Pharmacological Treatment;Phase;Physiological;preempt;Process;protective effect;protective pathway;Race;Rat Strains;Rat Transgene;Rattus;Recycling;Risk;Risk Reduction;Senile Plaques;Skeletal Muscle;tau Proteins;Tauopathies;Therapeutic;Therapeutic Intervention;Time;Tissues;transgenic model of alzheimer disease;treatment planning

PROJECT_TITLE: Effect of dietary restriction and exercise on behavioral outcomes and brain pathology in a transgenic model of Alzheimer's disease


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Neurosciences

PHR: PROJECT NARRATIVE: WISNIEWSKI PROJECT  Not applicable. See Overall plan.

PI_NAMEs: WISNIEWSKI, MATTHEW G. (contact)

PROJECT_TERMS: Area;Auditory;Auditory area;Brain;Cognitive;cognitive neuroscience;Communication;Complex;Computer Models;Data;Data Correlations;density;Dependence;Development;Devices;Discrimination;Disparate;Electroencephalography;Electrophysiology (science);Event;Exposure to;falls;Frequencies;Goals;Head;Health;Human;independent component analysis;indexing;Individual;innovation;insight;Judgment;Knowledge;Language;Learning;Left;Linguistics;Link;Location;long term memory;Magnetic Resonance Imaging;Measures;member;Memory;Memory Disorders;memory process;memory retrieval;Methodology;Methods;Modeling;neural;Neurobiology;neuroinformatics;Neuronal Plasticity;neuroregulation;Neurosciences;Outcome;Perception;Performance;Periodicity;Phase;Play;Protocols documentation;Published Comment;Rehabilitation therapy;repetitive transcranial magnetic stimulation;Research;response;Role;Scalp structure;Self-Help Devices;Sensory;Short-Term Memory;sound;Source;stem;Stimulus;Synaptic plasticity;System;Techniques;Testing;theories;Time;Visual;Work

PROJECT_TITLE: The role of prestimulus oscillatory brain dynamics in auditory memory


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: CLEVELAND

ORG_DEPT: PATHOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative:  Autoimmune and inflammatory diseases affect tens of millions of people in the United States39 and are characterized by a significant reduction in IgG sialylation, although the mechanisms underlying this dysregulation remain unclear. Conversely, treatment with exogenous and sialylated IgG in the form of IVIg therapy reverses autoimmune inflammation and helps to restore homeostasis. This proposal seeks to elucidate the regulatory mechanisms underlying changes in endogenous IgG sialylation, which we believe will ultimately provide a novel therapeutic target for sufferers of chronic and autoimmune inflammatory conditions.

PI_NAMEs: GLENDENNING, LEANDRE  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Affect;Affinity;Anti-Inflammatory Agents;Antibodies;Autoimmune;Autoimmune Diseases;autoimmune inflammation;Autoimmunity;Automobile Driving;B-Lymphocytes;Back;Binding;Blood Circulation;career;Cell Line;Cell surface;cell type;Cells;Central Nervous System;Chronic;chronic autoimmune disease;Clustered Regularly Interspaced Short Palindromic Repeats;Confocal Microscopy;Coupled;Data;design;Disease;Elements;Endosomes;Endothelial Cells;Endothelium;Environment;Enzymes;experience;extracellular;Fc domain;Fc Receptor;Glycobiology;Glycoproteins;glycosylated IgG;Goals;Golgi Apparatus;Half-Life;Health;HIV;Homeostasis;Human;immune activation;Immune response;Immunoglobulin G;Immunology;Immunosuppression;In Vitro;in vivo;Incubated;Infection;Inflammation;Inflammatory;Inflammatory Response;Ingestion;Knock-out;Knockout Mice;Leadership;Mammals;Methods;Molecular;Molecular Conformation;mouse model;Mouse Strains;Mus;new therapeutic target;novel;Pathway interactions;Persons;Plasma;Plasma Cells;Play;Polysaccharides;Positioning Attribute;Process;protein function;Reaction;receptor binding;Recycling;Regulation;Regulatory Pathway;Research;Rheumatoid Arthritis;Role;Sialic Acids;sialylation;Sialyltransferases;Signal Transduction;Stimulus;success;Tissues;trafficking;Training;trans-Golgi Network;Translating;Translational Research;Tuberculosis;United States;Vesicle

PROJECT_TITLE: Regulation of IgG Sialylation


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Lung;Lung Cancer;Patient Safety;Prevention;Substance Misuse;Telehealth;Tobacco;Tobacco Smoke and Health

ORG_CITY: KANSAS CITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

PHR: PROJECT NARRATIVE Smoking cessation treatment for hospitalized patients must continue when they leave the hospital in order to achieve the best results. Most smokers, however, return to smoking soon after leaving the hospital. This research will develop and test interventions to engage smokers in post-discharge smoking cessation treatment which will positively impact the long-term health of more than 4 million smokers that are hospitalized every year in the U.S.

PI_NAMEs: CRUVINEL, ERICA NICHOLS (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: Abstinence;acceptability and feasibility;Address;Adherence;alcohol tobacco and other drug use;Area;arm;Behavior;behavior change;Behavioral;behavioral clinical trial;Biochemical;care delivery;career;Caring;Clinical;clinical practice;Clinical Trials;Combined Modality Therapy;contingency management;Counseling;Data;design;Development;effective therapy;efficacy study;efficacy trial;evidence base;experience;feasibility testing;financial incentive;follow-up;Future;Goals;Health;Hospitalization;Hospitals;improved;Incentives;innovation;Inpatients;Intervention;intervention refinement;Interview;Kansas;Knowledge;Length of Stay;Link;Medicaid;Medical center;medication compliance;Mentors;Methods;mHealth;mhealth interventions;Morbidity - disease rate;mortality;nicotine gum;novel;novel strategies;Outcome;Participant;patient engagement;Patients;payment;Pharmaceutical Preparations;Pharmacotherapy;pill;Postdoctoral Fellow;Procedures;quitline;Randomized;randomized trial;Randomized, Controlled Trials;recruit;remote delivery;Reporting;Research;Research Personnel;research study;skills;Smoker;Smoking;Smoking Cessation Intervention;Structure;success;Surveys;System;Telefacsimile;Telephone;Testing;text messaging intervention;therapy development;Tobacco;tobacco cessation intervention;Tobacco Dependence;tobacco user;Training;Underserved Population;Universities;varenicline;wasting

PROJECT_TITLE: USING CONTINGENCY MANAGEMENT TO PROMOTE ADHERENCE TO SMOKING CESSATION TREATMENT AMONG HOSPITALIZED SMOKERS

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: BIOLOGY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Project Narrative Mitochondria produce the essential energy needed for neurons to function properly. These organelles are dynamic and move throughout the cell during the lifetime of the neuron; however, little is known about the functional relevance of this movement of mitochondria and how it contributes to the function of the neuron. This proposal will elucidate the fundamental in vivo steady state localization of mitochondria in order to better understand how neurons maintain healthy distributions of mitochondria across their complex structures over their entire lifetime.

PI_NAMEs: DONOVAN, EAVAN JANE (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Adaptor Signaling Protein;Adult;Affect;Architecture;Biogenesis;Calcium;Calcium Signaling;cell type;Cells;Collaborations;Complex;confocal imaging;Confocal Microscopy;Data;Defect;Dendrites;Disease;Drosophila genus;Drosophila melanogaster;Energy Supply;experimental study;Future;Generations;genetic manipulation;Goals;Health;Hour;Immunohistochemistry;in vivo;in vivo Model;insight;live cell imaging;Maintenance;mathematical model;Measurement;Measures;Metabolic;Mitochondria;Modeling;Molecular;Motility;Motor;Movement;Natural regeneration;Nerve Degeneration;neuronal patterning;Neurons;Organelles;Pattern;Physiological;Play;Population Dynamics;Proteins;reconstruction;Regulation;Reporter;Research;response;Role;self organization;Shapes;Signal Transduction;Site;Spatial Distribution;Structure;Synapses;System;Testing;Time;Visual System

PROJECT_TITLE: Regulation and function of mitochondrial motility in neurons in vivo


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: WALTHAM

ORG_NAME: BRANDEIS UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative Synthesis of new protein is necessary for the long-term adaptations in synaptic structure and function that are required for learning and memory formation. CaMKII, an important neuronal protein, is synthesized after neuronal activity, but it is not well understood how this process is controlled, nor how it is coordinated presynaptically and postsynaptically. This project will build an understanding of these mechanisms and may provide insight into brain disorders linked to CaMKII dysfunction such as intellectual disability and Alzheimer’s disease.

PI_NAMEs: CLEMENTS, KELSEY  (contact)

PROJECT_TERMS: 3' Untranslated Regions;Adult;Affect;Affinity Chromatography;Alleles;Alzheimer's Disease;Axon;Binding;Binding Proteins;Binding Sites;Biological Models;Brain Diseases;Ca(2+)-Calmodulin Dependent Protein Kinase;calmodulin-dependent protein kinase II;Catalytic Domain;Cells;Chemosensitization;Communication;CRISPR/Cas technology;Cycloheximide;Data;Dendrites;Drosophila genus;Elements;Excision;experimental study;fly;Frequencies;Functional disorder;Genes;Genetic;Genetic Recombination;Goals;Growth;Image Analysis;Imaging Device;inhibitor;insight;Intellectual functioning disability;Invertebrates;Learning;Link;Mammals;Memory;MicroRNAs;Modeling;Modification;Molecular;Motor Neurons;Movement;Muscle;nano;Neuromuscular Junction;Neurons;Physiologic pulse;postsynaptic;Potassium;presynaptic;Process;Protein Biosynthesis;Protein translocation;protein transport;Proteins;Protocols documentation;Reporter;Research;Research Design;Research Proposals;RNA;RNA-Binding Proteins;Role;Side;skills;Spatial Distribution;Statistical Data Interpretation;Stimulus;Structure;superresolution imaging;superresolution microscopy;Synapses;synaptic function;System;tool;Training;Trans-Activators;Translations;Untranslated Regions

PROJECT_TITLE: Identifying the Mechanisms and Localization of Activity-Dependent CaMKII Synthesis


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Neurodegenerative;Neurosciences;Opioids;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: Project Narrative Substance Use Disorder (SUD) and HIV-Associated Neurocognitive Disorder (HAND) are disorders for which we have an incomplete knowledge of pathobiological processes in the human CNS, hindering the search for new therapeutic targets. To address this challenge, we dissect the transcriptional and epigenetic changes associated with SUD and persistent HIV infection at single-cell resolution across seven human brain regions, generating a total of 28 million genome-wide single-cell maps across 2800 samples, integrate the resulting datasets to predict driver genes, in order to identify disorder driver genes, regulatory regions, variants, and pathways, and the cell types and brain regions where they act, and validate high-priority findings at the molecular level in human samples and in a mouse model of in vivo cocaine self-administration. The resulting datasets, computational inferences, and biological findings will provide an invaluable resource for understanding HIV, SUD, and HAND, and help guide the development of new therapeutic avenues against these devastating disorders.

PI_NAMEs: HEIMAN, MYRIAM ;KELLIS, MANOLIS  (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: addiction;Addictive Behavior;Address;Affect;Amygdaloid structure;Animal Model;Animals;antiretroviral therapy;Atlases;base;Biological;Biological Assay;Brain;Brain region;Cell Physiology;cell type;Cells;Characteristics;Chronic;Cocaine;cocaine self-administration;cocaine use;cohort;Corpus striatum structure;Country;Data;data integration;Data Set;Dementia;Development;Disabling;Disease;disorder control;Dissection;DNA;Dorsal;Enhancers;Epigenetic Process;epigenomics;Event;experience;Exposure to;Future;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic signature;Genetic Transcription;genome-wide;Genomics;Hippocampus;HIV;HIV Infections;HIV-associated neurocognitive disorder;HIV/AIDS;Human;human tissue;immune function;In Situ Hybridization;in vivo;in vivo Model;Individual;Infection;Insula of Reil;Knowledge;Link;M cell;Maps;Mediation;Molecular;mortality;mouse model;Mus;National NeuroAids Tissue Consortium;Nervous System Disorder;Neurobiology;Neurocognitive Deficit;neuroinflammation;Neuronal Injury;new therapeutic target;novel therapeutics;Nucleic Acid Regulatory Sequences;Nucleus Accumbens;Opioid;opioid use;Pathway interactions;Patients;pharmacologic;Phenotype;Predisposition;Prefrontal Cortex;Process;Property;Proteins;Regulator Genes;Resolution;Resources;response;RNA;Sampling;single cell ATAC-seq;single-cell RNA sequencing;Specificity;substance use;Substance Use Disorder;therapeutic target;trait;transcriptomic profiling;transcriptomics;Untranslated RNA;Validation;Variant;Ventral Tegmental Area;Viral Load result;Withdrawal Symptom

PROJECT_TITLE: Single Cell Transcriptomic and Epigenomic Dissection of Opioid and Cocaine Responses in HIV


NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Pediatric;Primary Immunodeficiencies;Rare Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Primary Immunodeficiencies (PIDs) are inborn errors of the immune system, affecting 1:780 hospitalized children. Despite widespread incomplete penetrance leading to difficulties in the study and clinical management of these diseases, we have a very limited understanding of the factors that drive phenotypic variability. This proposed study will uncover PID genes that are regulated by monoallelic expression (MAE) and the impact the resulting transcriptional heterogeneity has on disease penetrance, setting the foundation for future work aimed at manipulating MAE to reduce the burden of PIDs on child health.

PI_NAMEs: STEWART, O'JAY  (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Affect;Alleles;autosome;B-Lymphocytes;Biological;Biological Assay;Blood Cells;Cell Degranulation;Cell Differentiation process;Cell division;Cell Line;cell type;Cells;Child Health;Chromatin;Classification;Clinical Management;Clone Cells;Complex;congenital immunodeficiency;cytokine;Data;Disease;Disease Management;disease phenotype;Exhibits;exome sequencing;Family;Family member;Flow Cytometry;Foundations;Future;gain of function;gain of function mutation;Gene Cluster;Gene Expression;Gene Mutation;Gene Silencing;Genes;Genetic;Genetic Diseases;Genetic Transcription;Hereditary Disease;Heterogeneity;Heterozygote;Hospitalized Child;Human;human disease;Immune;Immune system;Immune System Diseases;imprint;Individual;Inherited;Interferons;JAK1 gene;Maps;mast cell;Medical Genetics;Mendelian disorder;Mitochondrial DNA;Mitotic;mutant;Mutation;Natural Killer Cells;Other Genetics;Outcome;Parents;Patients;Penetrance;Peripheral Blood Mononuclear Cell;Phenotype;Physiological;PLCG2 gene;Population;Population Heterogeneity;Prevalence;release of sequestered calcium ion into cytoplasm;Reporting;response;Role;selective expression;Severity of illness;Signal Transduction;Single Nucleotide Polymorphism;single-cell RNA sequencing;Sorting;Surface;System;T-Lymphocyte;Therapeutic;Time;Transcript;transcriptome;transcriptome sequencing;Variant;Work;X Chromosome;X Inactivation

PROJECT_TITLE: The Role of Monoallelic Expression in Incomplete Penetrance of Primary Immunodeficiencies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-A(20)L]


NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Malaria;Orphan Drug;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Project Narrative Drug resistance to the most effective antimalarials – the artemisinin-class drugs – has established itself and become widespread in Southeast Asia, posing a serious global health threat should these parasites be imported into Africa. Here, we will use individual-based epidemiological simulation to propose and evaluate strategies for how countries can best prepare for the arrival of artemisinin-resistant genotypes. These strategies will aim to prevent, delay, and mitigate the detrimental effects of imported artemisinin resistance.

PI_NAMEs: BONI, MACIEJ F (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Africa;Africa South of the Sahara;African;Age;Anti-malarial drug resistance;Anti-malarials;Artemisinins;Automobile Driving;Binding;Burkina Faso;Cambodia;Case Study;Cessation of life;Child;Chloroquine;Clinical;Clinical Trials;Combined Modality Therapy;Country;Culicidae;Dangerousness;Data;Disease;Drops;Drug Kinetics;drug market;Drug Modelings;Drug Prospecting;Drug resistance;Drug usage;Elements;epidemiological model;Epidemiology;Evaluation;Evolution;Falciparum Malaria;Frequencies;Genotype;global health;Guidelines;Human;improved;Individual;Intervention;Invaded;Link;Malaria;malaria transmission;Maps;Mathematics;Medicine;Mefloquine;Methods;Modeling;Mosquito Control;novel;novel strategies;novel therapeutics;Outcome;Parasites;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Phenotype;Plasmodium falciparum;Policies;Population;Predisposition;preempt;Preparation;Prevalence;prevent;Privatization;Probability;Process;Pyrimethamine;Recommendation;Recording of previous events;Research;Resistance;resistance mechanism;Risk;risk minimization;Rotation;Running;simulation;Southeastern Asia;Structure;Sulfadoxine;Therapeutic;transmission process;Treatment Efficacy;Treatment Failure;Variant;vector control;World Health Organization;Writing;Zambia

PROJECT_TITLE: Preparing for a world with artemisinin resistance: using individual-based epidemiological modeling to minimize the long-term detrimental effects of antimalarial drug resistance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(90)]


ORG_CITY: SAN DIEGO

ORG_DEPT: CHEMISTRY

ORG_NAME: SAN DIEGO STATE UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Atropisomerism is a dynamic type of chirality that is ubiquitous in modern drug discovery. Our research program revolves arounds exploiting the conformational space about atropisomeric axes to program target selectivity into promiscuous small-molecules, leading to compounds with fewer off-target effects as leads towards safer therapeutics and more precise tool compounds. Our research program also strives to develop enabling synthetic methodologies that allow for facile access to pharmaceutically relevant atropisomeric scaffolds in enantiopure form.

PI_NAMEs: GUSTAFSON, JEFFREY LOUIS (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Active Sites;Adverse event;analog;Binding;Biological;Breathing;Chemistry;conformer;Cyclization;Development;drug discovery;enantiomer;FDA approved;Goals;improved;inhibitor;kinase inhibitor;Methodology;Modernization;Molecular Conformation;nucleophilic substitution;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Phosphotransferases;programs;prospective;Research;Rotation;Sampling;scaffold;small molecule;small molecule inhibitor;Structure;Therapeutic;tool;Variant;Work

PROJECT_TITLE: MIRA: Atropisomerism as an inspiration for drug discovery and new chemistry


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Women's Health Research

ORG_CITY: CINCINNATI

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Relevance to Public Health: Müllerian Inhibiting Substance (MIS) is a member of the TGFβ superfamily which plays important roles during the development of both male and female reproductive systems. Aberrant MIS signaling in males is associated with Persistent Mullerian Duct Syndrome (PMDS). In women, MIS plays an important role in folliculogenesis. Our studies will bring to light how the MIS ligand interacts with its cellular receptors to activate signaling. We anticipate these molecular studies will open up new therapeutic avenues for modifying MIS activity.

PI_NAMEs: THOMPSON, THOMAS B (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: adeno-associated virus 9 delivery;Adopted;Adult women;Affinity;Agonist;analog;antagonist;Anti-Mullerian Hormone Receptor Type II;Binding;Biochemical;Biological;Biological Assay;Biological Markers;Biological Models;Biology;Biophysics;bone morphogenetic protein receptor type I;Cell Culture Techniques;Cells;Cervix Uteri;chemotherapy;Complex;Data;Development;Embryonic Development;Engineering;extracellular;Extracellular Domain;Family;Female;female reproductive system;Fertility;Fetus;folliculogenesis;Future;Generations;granulosa cell;Hand;Human;human female;In Vitro;in vivo;insight;Laboratories;Ligand Binding;Ligand Binding Domain;Ligands;male;Male Genital Organs;Mammalian Oviducts;Measures;member;Membrane Proteins;Modeling;Molecular;mullerian-inhibiting hormone;Mullerian-inhibiting substance receptor;Mutation;Nature;novel;novel therapeutics;Ovarian;Ovarian Ablation;ovarian reserve;Ovary;Phosphorylation;Phosphotransferases;Play;Polycystic Ovary Syndrome;primary ovarian insufficiency;Production;Public Health;rational design;Reagent;receptor;Receptor Signaling;Recombinant Proteins;Reproducibility;Reproduction;reproductive;Reproductive Biology;reproductive system disorder;Research Personnel;Roentgen Rays;Role;Serum;Sex Differentiation;Signal Transduction;Signaling Protein;small molecule;Specificity;structural biology;Structure;Structure of paramesonephric duct;Subcellular structure;substance use;Surface Plasmon Resonance;Syndrome;Testing;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;Urogenital ridge structure;Uterus;Woman;Work;X-Ray Crystallography

PROJECT_TITLE: Structure-function analysis of Mullerian Inhibiting Substance (MIS)

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


ADMINISTERING_IC: CA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Genetic Testing;Genetics;Lung;Lung Cancer;Nanotechnology;Precision Medicine

ORG_CITY: STANFORD

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Targeted therapy for the treatment of non-small cell lung cancer (NSCLC) has greatly improved patient outcomes compared to traditional chemotherapy. However, it is estimated that up to 20% of lung cancer patients receive first-line therapy prior to Epidermal Growth Factor Receptor (EGFR) mutational analysis, necessitating the need for a rapid and cheap blood-based circulating tumor (ct) DNA test for efficient therapy selection. Additionally, ctDNA can be useful for ‘liquid biopsy’ and monitoring of response to therapy or acquired resistance to therapy. We have successfully developed a highly multiplexable magneto-nanosensor assay for the detection of “hot spot” mutation panel for lung cancer targeted therapy monitoring and prognosis. This project is expected to result in clinical validation of a ctDNA EGFR magneto-nanosensor assay, expanding and multiplexing the existing EGFR assay to include Kirsten RAt Sarcoma (KRAS) mutation and certain gene-fusions, and utilizing the expanded assay [for efficient therapy selection and/or therapy response monitoring, and prognosis.]

PI_NAMEs: WANG, SHAN X. (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: actionable mutation;Adoption;Biological Assay;Biopsy;Blood;Blood specimen;Blood Tests;BRAF gene;Cancer Patient;cancer type;chemotherapy;Clinical;cohort;cost effective;Detection;detection assay;Disease;Disease Progression;Epidermal Growth Factor Receptor;Exons;experience;follow-up;fusion gene;Gene Fusion;Generations;Genes;Goals;Hot Spot;Image;improved;inhibitor therapy;innovation;liquid biopsy;Magnetic nanoparticles;Malignant neoplasm of lung;Monitor;mutant;Mutation;Mutation Analysis;mutation assay;nanosensors;Non-Small-Cell Lung Carcinoma;Outcome;Patient imaging;Patient Monitoring;Patient-Focused Outcomes;Patients;Pilot Projects;Plasma;Prior Therapy;Prognosis;prognostic;Progression-Free Survivals;radiological imaging;Rattus;resistance mechanism;resistance mutation;response;ROS1 gene;Sampling;Sarcoma;Selection for Treatments;Sensitivity and Specificity;Specificity;targeted cancer therapy;targeted treatment;Testing;therapy resistant;Time;Translating;treatment response;tumor DNA;Tyrosine Kinase Inhibitor;Validation

PROJECT_TITLE: Rapid and affordable magneto-nanosensors for ctDNA-guided lung cancer management


NIH_SPENDING_CATS: Bioengineering;Infectious Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative - Public Health Relevance  Bacterial biofilms are responsible for a large number of hospital-acquired infections, and currently used antibiotic and disinfection treatments are unable to cope with this epidemic. An integrated understanding of how individual bacterial cells act and interact with each other inside biofilms is necessary to inform new strategies for controlling biofilm growth. This project enables high-resolution, single-cell measurements inside living biofilms by developing new technologies for non-invasive biofilm imaging and computational tracking of thousands of bacterial cells in crowded environments.

PI_NAMEs: GAHLMANN, ANDREAS  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 3-Dimensional;Address;Algorithms;antibiotic tolerance;Antibiotics;Architecture;Bacteria;bacterial community;Bacterial Infections;Behavior;behavioral phenotyping;Biochemical;Biological;Biology;Calibration;cell behavior;cell dimension;Cell Shape;cell type;Cells;cellular imaging;Cessation of life;Chemicals;Communities;Computer Models;Computer software;coping;Crowding;Development;Disinfection;Environment;environmental stressor;Epidemic;Escherichia coli;Eukaryotic Cell;Exhibits;fluorescence imaging;Gene Activation;Gene Expression;gene regulatory network;Genetic Transcription;Geometry;Growth;Health;high resolution imaging;Hospitals;Human;Human Microbiome;human pathogen;Image;image processing;imaging modality;imaging platform;Immersion;Immune system;Individual;Industrialization;Knowledge;lens;Life Style;Light;Linear Programming;live cell imaging;Machine Learning;Mathematics;Measurement;Measures;mechanical signal;meter;microbial;Microbial Biofilms;microbial community;Microscope;Microscopy;model design;morphometry;Myxococcus xanthus;new technology;Nosocomial Infections;Optics;pathogenic bacteria;Pathogenicity;Phenotype;Physiology;Population;Positioning Attribute;prevent;Property;public health relevance;Reading;Reporter;Reporter Genes;Research;Research Personnel;Resolution;seal;Shapes;Shigella flexneri;social;Social Behavior;Specimen;stressor;Sum;supervised learning;Surface;System;Techniques;Technology;temporal measurement;Testing;Thick;Time;Tissues;United States;Validation;Water

PROJECT_TITLE: Non-Invasive Single-Cell Morphometry and Tracking in Living Bacterial Biofilms

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Radiation Oncology

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative This K12 Program trains scholars who are cancer-focused clinicians to effectively partner with laboratory scientists. Scholars will learn to communicate their research to diverse audiences and build successful research teams that leverage expertise in different areas. Scholars will be taught how to conduct innovative and impactful research that integrates the patient perspective and the latest scientific advances, with the overall goal of improving the care of individuals with cancer.

PI_NAMEs: BERGSLAND, EMILY K (contact);BIVONA, TREVER G

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Advisory Committees;anti-cancer research;Area;Basic Cancer Research;bench to bedside;Biological Markers;Biometry;Biostatistical Methods;cancer clinical trial;career development;certificate program;Clinic;Clinical;Clinical Oncology;Clinical Research;clinical translation;community advisory board;community engagement;Competence;Comprehensive Cancer Center;design;Development;Development Plans;drug development;Educational Curriculum;Educational workshop;Eligibility Determination;Ensure;Environment;Epidemiologic Methods;experience;Faculty;Family;Fostering;Funding;Goals;Grant;health care disparity;Health Sciences;Image;improved;Individual;innovation;interest;Investigational Therapies;K-Series Research Career Programs;Laboratories;Lead;Malignant Childhood Neoplasm;Malignant Neoplasms;Medical Oncology;Mentored Clinical Scientist Development Program;Mentors;Monitor;multidisciplinary;NCI Center for Cancer Research;neuro-oncology;next generation;patient oriented;Patient Outcomes Assessments;Physicians;post-doctoral training;Program Development;programs;Protocols documentation;Radiation Oncology;Research;research and development;Research Methodology;Research Personnel;responsible research conduct;Rotation;Science;Scientist;Series;skills;success;Surgical Oncology;Technology;tool;Training;Training Programs;translational cancer research;Translational Research;Work;Writing

PROJECT_TITLE: UCSF Paul Calabresi K12 Career Development Program in Clinical Oncology

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Chromosomes are the foundation for organizing our genomes and vehicles for genetic inheritance. The goal of this project is to construct the first synthetic mammalian artificial chromosomes that follow Mendel’s laws, from minimal components. Success will transform our fundamental understanding of what comprises a mammalian chromosome and have wide-ranging applications in synthetic biology and biotechnology, such as creation of animal models for drug development and as sources of personalized organs for transplantation.

PI_NAMEs: BLACK, BEN E. (contact);LAMPSON, MICHAEL

PROGRAM_OFFICER_NAME: MORRIS, STEPHANIE A

PROJECT_TERMS: Address;Animal Model;Animals;Area;Artificial Chromosomes;Artificial Mammalian Chromosomes;Behavior;Biological Models;Biotechnology;Cell division;Centromere;centromere protein A;Chromatin;Chromosomal Stability;Chromosome Pairing;Chromosomes;Circular DNA;Clinic;Custom;Data;design;Development;DNA;DNA Sequence;drug development;Elements;Embryo;Ensure;Epigenetic Process;Eukaryota;Female;Foundations;frontier;Genes;Genetic;genetic element;genetic payload;Genetic Recombination;Genome;Genome Components;Genome engineering;Germ Cells;Germ Lines;Goals;Harvest;Histones;Human Chromosomes;Human Genome Project;In Vitro;in vivo;Industrialization;Inherited;innovation;insight;Investments;Laws;Mammalian Cell;Mammalian Chromosomes;Mammals;Medicine;Meiosis;Mitosis;Mitotic;Mitotic Cell Cycle;mouse model;Mus;Nucleic Acid Sequence Homology;Nucleosomes;Organ Transplantation;Outcome;Patients;Privatization;Prophase;quantum;Research Personnel;Research Project Grants;Saccharomycetales;segregation;Sex Chromosomes;Sexual Reproduction;Source;Specific qualifier value;success;synthetic biology;synthetic construct;Technology;telomere;Testing;Time;tool;transmission process;Variant;vector;Work;Writing;Yeasts

PROJECT_TITLE: Mendelian inheritance of artificial chromosomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J(70)R]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Osteoporosis

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative: Proline uptake and metabolism via the proline cycle is a critical regulator of cancer cell survival and proliferation, however the role of proline uptake and the proline cycle during osteoblast differentiation and bone formation is unknown. Data generated by this proposal will: 1) establish the necessity and regulation of proline uptake and metabolism during physiological bone formation, and 2) eludicate the role of the proline cycle during osteoblast differentiation and bone formtation. Our findings will have broad implications in bone development and the maintenance and regeneration of bone mass.

PI_NAMEs: KARNER, COURTNEY MICHAEL (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Address;Affect;Alleles;American;Amino Acid Transporter;Amino Acids;aminoacid biosynthesis;Anabolism;ATP Synthesis Pathway;Back;bone;Bone Development;bone mass;Bone Matrix;bone quality;Bone Regeneration;Bone Resorption;cancer cell;carboxylate;Cell Proliferation;Cell Survival;Cells;Collagen;Complex;Consumption;Coupling;Data;Defect;differentiation in vitro;Disease;Disease Progression;Electron Transport;Electrons;Enzymes;extracellular;genetic approach;Glycolysis;Health Care Costs;Homeostasis;Imino Acids;in vitro activity;in vivo;Individual;Knowledge;Maintenance;Membrane;Metabolic;Metabolism;metabolomics;Molecular;Mus;NADH;Natural regeneration;Neutral Amino Acid Transport Systems;new therapeutic target;osteoblast differentiation;Osteoblasts;Osteogenesis;Osteopenia;Osteoporosis;oxidation;Pathway interactions;Patients;Pentosephosphate Pathway;Pharmaceutical Preparations;Physiologic Ossification;Physiological;polypeptide;prevent;Process;Production;progenitor;Proline;Proline Dehydrogenase;proline permease;Protein Biosynthesis;Proteins;pyrroline;pyrroline 5 carboxylate reductase;Regulation;repaired;Role;skeletal;System;uptake;WNT Signaling Pathway;Work

PROJECT_TITLE: The Role of Proline Metabolism During Osteoblast Differentiation and Bone Formation

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Cardiac fibrosis contributes to structural and biological changes that ultimately lead to heart failure, a major cause of morbidity and mortality. We seek to develop new imaging agents to evaluate the process of fibrosis and validate them in mouse models of cardiac fibrosis. Ultimately, this should lead to better management of not only cardiomyopathy, but also a wide range of other fibrotic disorders.

PI_NAMEs: SADEGHI, MEHRAN M (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Address;Affinity;Aorta;aorta constriction;Aortic Valve Stenosis;Binding;Biological;Cardiac;Cardiomyopathies;Characteristics;Cicatrix;Classification;clinical translation;Collagen;Collagen Fiber;Collagen Type I;coronary fibrosis;Data;Deposition;design;Development;Diagnostic;Diffuse;Disease;Drug Kinetics;Extracellular Space;Fibroblasts;fibrogenesis;Fibrosis;Functional disorder;Glycine;Heart;Heart failure;Heart Hypertrophy;heart imaging;Histology;Hydroxyproline;Hypertension;Hypertrophic Cardiomyopathy;Image;imaging agent;imaging approach;imaging modality;improved;In Vitro;in vivo;Infarction;Inflammation;Injury;Integrins;interstitial;Lead;lead optimization;Left Ventricular Remodeling;Magnetic Resonance Imaging;Matrix Metalloproteinases;Modeling;molecular imaging;Molecular Structure;Morbidity - disease rate;mortality;mouse model;Myocardial Infarction;myocardial injury;Myocardium;Myofibroblast;novel;novel strategies;Pathology;Patient Selection;Peptide Hydrolases;Peptides;Performance;Photons;Positron-Emission Tomography;pressure;prevent;Process;prognostic;prognostication;Proliferating;Proline;prototype;radiotracer;Resolution;Role;Secondary to;self assembly;single photon emission computed tomography;Specificity;structural imaging;Structure;targeted agent;targeted imaging;targeted treatment;Therapeutic Effect;Therapeutic Intervention;Tissues;tool;Tracer;triple helix;Ventricular;Ventricular Remodeling;X-Ray Computed Tomography

PROJECT_TITLE: Molecular Imaging of Collagen Turnover in Cardiomyopathy

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Treatment with radiolabeled antibodies targeting the cell surface protein CD33 holds great promise for acute myeloid leukemia (AML) but “on-target, off-tumor cell” toxicity to normal CD33-expressing blood cells limits clinical use. To overcome this limitation, we will optimize a so-called base editor (BE) technology to efficiently remove CD33 from normal blood cells that we believe is safer and more precise than another technology (called CRISPR/Cas9 editing) that is now entering patient testing. We will conduct well-controlled preclinical studies to develop this BE method for patients at risk for recurrence/development of CD33-expressing neoplasms to enable safe treatment with radiolabeled anti-CD33 antibodies.

PI_NAMEs: WALTER, ROLAND BRUNO (contact)

PROGRAM_OFFICER_NAME: CHRISTEN, JAYNE

PROJECT_TERMS: Actinium;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Adenine;Adverse event;Animal Model;Animals;Antibodies;Antibody-drug conjugates;Antigens;arm;Astatine;Autologous;base editing;base editor;Blood Cells;Cell Cycle Arrest;cell killing;Cell surface;Cell Surface Proteins;Cells;Chromosomal Rearrangement;Clinic;Clinical;clinical translation;clinically relevant;Complex;Coupled;CRISPR/Cas technology;Cytidine;Cytoprotection;Data;delivery vehicle;Development;Diameter;Disease;DNA Damage;DNA Double Strand Break;Dose;early onset;early phase clinical trial;Engineering;Engraftment;Focus Groups;Gemtuzumab Ozogamicin;gene-editing approach;Genes;Glycoproteins;Guide RNA;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Human;Human Engineering;humanized mouse;improved;improved outcome;In Vitro;in vivo;Infection;interest;leukemia;leukemic stem cell;Life;Measures;Mediating;Messenger RNA;Methods;Modeling;Modification;Monitor;Monoclonal Antibodies;mouse model;multidisciplinary;Mus;Mutation;Myeloid Cells;Myelosuppression;Neoplasms;neoplastic cell;next generation sequencing;nonhuman primate;Normal Cell;novel;nuclease;Nucleotides;particle;Patients;Pharmaceutical Preparations;pre-clinical;preclinical study;Proteins;Radiation;Radioimmunoconjugate;Radioimmunotherapy;Radioisotopes;Radiolabeled;Radiopharmaceuticals;reconstitution;Recurrence;Research Personnel;Resistance;response;Risk;safety assessment;screening;Stem cell transplant;stem cells;T-Lymphocyte;targeted treatment;Technology;Testing;Therapeutic;Toxic effect;TP53 gene;transplant model;Variant

PROJECT_TITLE: Base-Edited Hematopoietic Stem and Progenitor Cells To Enable Safe Use Of Highly Potent CD33-Targeted Radioimmunotherapy

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Aging;Arthritis;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Neurosciences;Osteoarthritis;Pain Research;Precision Medicine;Sleep Research

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE There is an urgent public health need to reduce our reliance upon opioids for effective long-term pain management, particularly in knee osteoarthritis (KOA), where the effectiveness of recommended treatments to improve pain and functional limitations are highly variable and identifying clinical and patient-level factors associated with treatment response is a high priority. Central sensitization and sleep disturbance have potent influence in shaping pain and treatment response, but the hypothesized mechanistic action requires further examination. These results will inform scholarly activity and lead to optimized patient-treatment selection.

PI_NAMEs: CAMPBELL, CLAUDIA MICHELLE (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Advocate;Affect;Ancillary Study;Behavioral;Body mass index;Caring;Central Nervous System;central sensitization;Chronic disability;chronic pain;chronic painful condition;Clinical;clinical pain;compare effectiveness;Coping Skills;Degenerative polyarthritis;design;disability;duloxetine;Economic Burden;effective intervention;Effectiveness;Equipment;Evaluation;experience;functional disability;Funding;Future;global health;Goals;Heterogeneity;High Prevalence;Hyaluronic Acid;Hyperalgesia;Hypersensitivity;improved;improved outcome;indexing;Individual;Individual Differences;Injections;Injury;Intervention;joint mobilization;Knee joint;Knee Osteoarthritis;knee replacement arthroplasty;Knowledge;Laboratories;Life Expectancy;Link;Literature;Longterm Follow-up;Maintenance;Measures;Modeling;Nerve;Nerve Block;neurotransmission;Nociception;older adult;Operative Surgical Procedures;Opioid;opioid therapy;osteoarthritis pain;Outcome;Outcome Measure;Pain;pain chronification;Pain Disorder;Pain management;pain model;pain outcome;pain processing;parent project;Patient Outcomes Assessments;patient response;patient subsets;Patients;Pattern;Peripheral;Persistent pain;Persons;pharmacologic;Phase;Phenotype;Physical Function;physical impairment;poor sleep;Population;precision medicine;predicting response;Prediction of Response to Therapy;Procedures;Public Health;Questionnaires;Radiofrequency Interstitial Ablation;radiological imaging;Randomized, Controlled Trials;Recommendation;recruit;Refractory;Reporting;Resources;response;Risk;Role;Selection for Treatments;Sensory;Severities;Shapes;Site;skills training;Sleep;Sleep Apnea Syndromes;Sleep Deprivation;Sleep disturbances;Sleeplessness;Societies;standard care;Symptoms;Testing;theories;Time;transmission process;treatment comparison;Treatment outcome;treatment response

PROJECT_TITLE: Central Sensitization and Sleep Disturbance as Predictors of Treatment Outcomes in Patients with Knee Osteoarthritis


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Hematology;Neurosciences;Rare Diseases;Sickle Cell Disease;Stroke

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Sickle cell anemia (SCA) is the most common disorder identified on newborn screening, affecting one in 1000 individuals worldwide, with a mean life expectancy of 42 years. Among its complications, stroke and cognitive disability are prevalent in adults with SCA and who experience a > 50% unemployment rate. In this grant, we will perform brain MRI and cognitive testing in adults with SCA and age/race-matched controls to investigate new mechanisms (neuroinflammation and capillary flow heterogeneity) which likely contribute to stroke and cognitive disability in adults with SCA; if present, these mechanisms may provide new therapeutic targets.

PI_NAMEs: AN, HONGYU ;FORD, ANDRIA LEE (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Adhesions;Adult;Affect;Age;Aging;Anemia;Binding;Biological Markers;Blood;Blood capillaries;Blood Vessels;Body Weight;Bone Marrow Transplantation;Brain;brain cell;brain magnetic resonance imaging;brain tissue;Cell Adhesion Molecules;Cerebral Hypoxia;Cerebral Infarction;Cerebral Ischemia;cerebral ischemic injury;Cerebrovascular Circulation;Cerebrum;Cessation of life;Child;Childhood;Chronic;Clinical;clinical predictors;Clinical Trials;cognitive disability;cognitive performance;cognitive testing;cohort;comparison control;Core-Binding Factor;cytokine;Cytokine Activation;Data;density;Diffusion;Disease;Disease stratification;disorder risk;Employment;Endothelium;Energy Metabolism;Erythrocytes;Erythropoiesis;experience;Failure;follow-up;Grant;Growth;hemodynamics;Hemolytic Anemia;Heterogeneity;high risk;hydroxyurea;Hypoxia;illness length;imaging biomarker;Impaired cognition;Individual;Infarction;Inflammation;inhibitor;interest;Investigation;Ischemia;Ischemic Brain Injury;ischemic injury;Kinetics;Leukocytes;Life Expectancy;Long term disability;Magnetic Resonance Imaging;Measures;Metabolic;Metabolic stress;Metabolism;Methods;Microvascular Dysfunction;Morphology;Neonatal Screening;Neurocognitive;neuroimaging;neuroinflammation;Neurologic;neuroprotection;new therapeutic target;novel;Organ;Oxygen;P-Selectin;Patients;Pattern;Physiology;Plasma Proteins;polymerization;Polymers;Population;predictive signature;Predisposition;premature;Race;Rest;Risk;Screening procedure;Selectins;Shapes;Sickle Cell;Sickle Cell Anemia;sickling;Specificity;spectrograph;Stroke;stroke risk;Structure;Surface;systemic inflammatory response;Testing;Tissues;Tracer;Transfusion;Unemployment;Vascular blood supply;vaso-occlusive crisis;white matter;Work;young adult

PROJECT_TITLE: MR-Derived Cerebral Oxygen Metabolism underlying Ischemic Vulnerability in Sickle Cell Disease

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Chronic Pain;Pain Research;Physical Injury - Accidents and Adverse Effects;Rehabilitation

ORG_DEPT: ANESTHESIOLOGY

PHR: NARRATIVE Over 30 million major surgeries are performed annually in the US alone. Delayed surgical recovery marked by persistent pain and prolonged functional impairment causes personal suffering, longer exposure to opioids, and decreased quality of life, contributing $8 billion annually to US health care costs. However, biological markers that allow us to accurately predict surgical recovery in individual patients are lacking. My research program will examine the human monocyte system in patients undergoing surgery to identify immunological mechanisms that predict a patient's recovery after surgery and point at modifiable targets for the development of immune- modulating interventions that will safely accelerate surgical recovery.

PI_NAMEs: GAUDILLIERE, BRICE  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Acceleration;Acute;adverse outcome;Biological;Biological Markers;Blunt Trauma;Cells;Clinical;Cytometry;Data;Development;Elements;Epigenetic Process;Evaluation;Exposure to;Functional impairment;Goals;Health Care Costs;high dimensionality;Homing;Human;Immune;Immune response;Immune system;Immune Targeting;Immunologic Monitoring;Immunologics;Immunology;immunoregulation;improved;individual patient;Infection;Inflammatory;innovation;Intervention;Metabolic;monocyte;mouse model;multidisciplinary;Neurocognitive Deficit;Operative Surgical Procedures;Opioid;Orthopedic Surgery;Pain;Patient Monitoring;patient population;Patients;Persistent pain;Phenotype;postoperative recovery;pre-clinical;programs;Property;Proteomics;Quality of life;Recovery;Recovery of Function;Replacement Arthroplasty;Research;Resolution;response;response to injury;risk prediction;Role;Scientist;Sepsis;Signal Transduction;surgery outcome;Surgical Injuries;Surgical Models;System;Techniques;Testing;translational approach;Translational Research;Trauma;Traumatic Brain Injury;Traumatic injury

PROJECT_TITLE: Harnessing the human monocyte system to improve surgical recovery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Neurofibromatosis;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Neurofibromatosis type 1 syndrome (NF1) is a common genetic disease and NF1 patients are predisposed to several kinds of cancer, especially nerve tumors that start benign but can become malignant. Unfortunately, treatment options for NF1-associated nerve tumors are limited. The goal of this proposal is to use careful genetic and chemical studies to find new drugs to treat and/or prevent the nerve sheath tumors in NF1 patients before they become malignant.

PI_NAMEs: LARGAESPADA, DAVID ANDREW (contact);RATNER, NANCY

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Address;Alleles;Allografting;autosome;Benign;C57BL/6 Mouse;cancer predisposition;CDKN2A gene;Cell Line;cell transformation;Cells;Chemicals;chemotherapy;Clustered Regularly Interspaced Short Palindromic Repeats;dermal neurofibroma;Detection;Development;DNA sequencing;drug candidate;Drug Screening;Drug Targeting;Environment;Epigenetic Process;Erinaceidae;Evolution;exome;gene product;Genes;Genetic;Genetic Diseases;Genetic Screening;Genetically Engineered Mouse;genetically modified cells;Genotype;Goals;Heritability;Heterozygote;Human;human data;Image Analysis;Immune system;Immunocompromised Host;immunodeficiency;immunoregulation;In Vitro;in vitro Model;in vitro testing;in vivo;in vivo Model;indexing;induced pluripotent stem cell;Lesion;Lethal Genes;Life;loss of function mutation;Loss of Heterozygosity;Malignant - descriptor;Malignant Neoplasms;Methods;Modeling;Modification;Molecular Target;molecular targeted therapies;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Mutation;Neoplasms;Nerve;Nerve Sheath Tumors;neurofibroma;Neurofibromatoses;Neurofibromatosis 1;Neurofibrosarcoma;new therapeutic target;NF1 gene;novel therapeutics;Operative Surgical Procedures;Pain;Patients;Perinatal;Peripheral Nerve Sheath Neoplasm;Peripheral Nerves;Persons;Pharmaceutical Preparations;Plexiform Neurofibroma;Population;Pre-Clinical Model;Preclinical Testing;Premalignant Cell;prevent;Prevention;Process;Prognosis;Protein Phosphatase 2A Regulatory Subunit PR53;recruit;Role;Schwann Cells;sciatic nerve;Soft tissue sarcoma;Source;subcutaneous;Surgical complication;Syndrome;System;Testing;Therapeutic Uses;Tissues;transcriptome;transcriptome sequencing;transplant model;tumor;tumor progression;tumor-immune system interactions;Wild Type Mouse

PROJECT_TITLE: Uncovering treatment targets for peripheral nerve sheath tumor progression in NF1

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG-R]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Endocannabinoid System Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Anxiety disorders commonly begin during adolescence, and are characterized by deficits in the ability to inhibit or extinguish pathological fear. Recent research has provided new understanding of how fear is learned and can be regulated in the adolescent brain, and how the endocannabinoid system shapes these processes; however, these advances have not yet translated into improved therapeutic outcomes for adolescents with anxiety. The proposed project will leverage a multi-modal experimental therapeutics approach to test whether a behavioral intervention (i.e., acute exercise) modifies hypothesized targets that are relevant for the pathophysiology and treatment of anxiety in youth.

PI_NAMEs: MARUSAK, HILARY  (contact)

PROGRAM_OFFICER_NAME: GARVEY, MARJORIE ANN

PROJECT_TERMS: Acute;Address;Adolescence;Adolescent;Adult;Aerobic Exercise;Affect;Age;anandamide;Animal Model;Anxiety;Anxiety Disorders;anxiety reduction;anxiety treatment;anxious;Award;Behavior Therapy;Biological Markers;Brain;brain circuitry;circulating biomarkers;Clinical;Cognitive Therapy;Communication;Control Groups;cost;Coupling;Data;Development;diagnostic criteria;Disease remission;efficacious treatment;endocannabinoid signaling;Endocannabinoids;endogenous cannabinoid system;ethnic minority population;Evidence based intervention;Evidence based treatment;Exercise;exercise intensity;Expectancy;Extinction;Fright;Functional disorder;Functional Magnetic Resonance Imaging;Galvanic Skin Response;Goals;Health Personnel;Hippocampus;Hour;Human;improved;improved outcome;Individual;innovation;Intervention;Investigational Therapies;K-Series Research Career Programs;Learning;learning extinction;Life;low socioeconomic status;Measures;memory consolidation;Mental Health;Methods;Minority Groups;multimodality;National Institute of Mental Health;neurodevelopment;neuroimaging;novel;Outcome;Pathologic;Patient Self-Report;Pharmacotherapy;Phase;Population Heterogeneity;preadolescence;Prefrontal Cortex;prevent;Prevention;preventive intervention;Process;Productivity;programs;Psychophysiology;Public Health;racial minority population;Randomized;recruit;Relapse;Research;Research Personnel;Resources;Risk;Risk Factors;Schools;sedentary;Shapes;Societies;standard measure;Stimulus;Testing;therapy outcome;Translating;treatment response;Work;Youth

PROJECT_TITLE: Exercise facilitation of adolescent fear extinction, frontolimbic circuitry, and endocannabinoids


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Dietary Supplements;Genetics;Neurosciences;Nutrition;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Glioblastoma is an aggressive, incurable type of brain tumors enriched in a subset population of glioma stem cells (GSCs) with self-renewal and tumor initiation capacities. We have established that the activity of a fatty acid desaturase enzyme is essential to maintain GSCs proliferation and tumor initiation in glioma mouse models. Our proposed studies will investigate regulations mechanisms and therapeutic targeting of this enzyme.

PI_NAMEs: BADR, CHRISTIAN ELIAS (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Acidosis;analog;Apoptotic;Automobile Driving;beta catenin;Binding;Biochemical;blood-brain barrier permeabilization;Brain;Brain Neoplasms;Cancer Control;cancer stem cell;CD36 gene;Cell Death;Cell Maintenance;Cellular Stress;Central Nervous System Neoplasms;clinical translation;Cues;Dependence;desaturase;Development;Dietary Fatty Acid;Dietary Supplementation;Disease;DNA Damage;DNA Repair;Double Effect;Ectopic Expression;Endogenous Factors;Endoplasmic Reticulum;endoplasmic reticulum stress;Environment;Enzymes;Fatty Acid Desaturases;fatty acid metabolism;Fatty Acids;Frequencies;Genes;Genetic;Genetic Transcription;Genomic Instability;Glioblastoma;Glioma;Growth;Homeostasis;Hypoxia;Impairment;Implant;In Vitro;in vivo;inhibitor;Inositol;Invaded;lipid biosynthesis;Lipid Synthesis Pathway;Lipids;Malignant - descriptor;Malignant Neoplasms;Mediating;misfolded protein;Modeling;Molecular;mortality;mouse model;Mus;new therapeutic target;NF-kappa B;Nose;novel;novel therapeutics;nutrient deprivation;Oncogenic;Parkinson Disease;Patients;pharmacologic;Phase I Clinical Trials;Phenotype;Population;prevent;Proliferating;Property;Proteins;Radiation;Radiation therapy;Recurrence;Recurrent tumor;Regulation;Regulatory Element;research clinical testing;response;Role;Route;Saturated Fatty Acids;self-renewal;sensor;Signal Pathway;Signal Transduction;small hairpin RNA;STAT3 gene;Stearoyl-CoA Desaturase;stem cell division;stem cell model;stem cell proliferation;stem cell self renewal;stem cells;stem-like cell;Sterols;Stress;Supplementation;targeted treatment;temozolomide;Testing;Therapeutic;Therapeutic Effect;therapeutic target;therapy outcome;therapy resistant;transcription factor;Transcriptional Activation;Treatment Efficacy;treatment response;tumor;tumor behavior;tumor growth;tumor initiation;tumor progression;tumorigenic;Unsaturated Fatty Acids;uptake;Work;Xenograft procedure

PROJECT_TITLE: Role of ER Stress and Fatty Acid Metabolism in Glioma Stem Cells

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Neurodegenerative;Neurosciences;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE: With the advent of antiretrovirals, the infection with HIV has become a chronic disease and fortunately people with HIV live longer but diseases usually seen in old people such as stroke and dementia have also become more common in this population. It is not clear how aging with HIV influences or changes the risk of dementia or cerebrovascular disease compared with aging population without HIV. This project aims to investigate whether HIV poses unique challenges that may need to be treated differently than in people without HIV so that people aging with HIV live healthier lives.

PI_NAMEs: GUTIERREZ, JOSE  (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Acceleration;Affect;Age;Aging;aging population;Alzheimer's Disease;Amyloid deposition;Anti-Inflammatory Agents;Anti-Retroviral Agents;antiretroviral therapy;Biological;Biological Markers;Blood;Blood Vessels;Cerebrovascular Disorders;Chronic;Chronic Disease;Clinical;Cognition;cohort;comorbidity;cytokine;Data;Dementia;dementia risk;Diabetes Mellitus;Disease;disease disparity;Disparity;disparity reduction;Dyslipidemias;Elderly;Endothelium;Equipoise;Ethnic Origin;Functional disorder;Future;Health;HIV;HIV disparities;HIV Seronegativity;HIV-associated neurocognitive disorder;Homophobia;Hypertension;Impaired cognition;Individual;Infection;Inflammation;Inflammatory;Injury;Intercellular adhesion molecule 1;Intercellular Adhesion Molecules;intercellular cell adhesion molecule;Knowledge;Lasso;Life Expectancy;Magnetic Resonance Imaging;Measures;Mediating;Mediation;Mediator;Modeling;Modification;Morbidity - disease rate;Nerve Degeneration;Older Population;Pathway interactions;Persons;Plasma;Population;Prevalence;Process;Production;Quality of life;Recommendation;Residual state;Risk;Role;sex;Smoking;social stigma;socioeconomics;stressor;Stroke;Structural Racism;Subgroup;synergism;tau-1;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;TNF gene;Translating;Vascular Cell Adhesion Molecule-1;vascular contributions;Vascular Diseases;vascular risk factor

PROJECT_TITLE: Vascular contributions to HIV-associated Neurocognitive Disorders (HAND)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-N(02)]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Pediatric

ORG_CITY: ANN ARBOR

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE American youth are growing up in more contextually varied circumstances. While it is established that these circumstances profoundly impact development, little is known about how they become biologically embedded and how this interaction with biology influences trajectories of developmental and health outcomes. The proposed training program will prepare predoctoral and postdoctoral students to bridge research in the developmental science of context and human neurobiology, with cutting-edge quantitative techniques, in order to decipher how the social environment interacts with genomics and the brain to guide development.

PI_NAMEs: GELMAN, SUSAN A.;MONK, CHRISTOPHER STEPHEN (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: developmental psychology;Grant;Training

PROJECT_TITLE: Developmental Psychology Training Grant


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Electronic Nicotine Delivery Systems;Lung;Lung Cancer;Pediatric;Prevention;Substance Misuse;Substance Misuse Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE There is little published data on exposure to and evaluations of large-scale, online tobacco control campaigns. The proposed R01 project addresses this gap. Under 2 specific aims, we will identify the independent effects of varying levels of digital message exposure to promote anti-tobacco attitudes, beliefs, or behaviors among youth and young adults, first through a randomized experiment online, and second through a field-based evaluation. These studies will advance the science of digital health and have wide application to future campaigns.

PI_NAMEs: EVANS, W. DOUGLAS (contact)

PROGRAM_OFFICER_NAME: D'ANGELO, HEATHER

PROJECT_TERMS: Address;Adult;Advertising;Age;aged;Agreement;Attitude;Awareness;Behavior;behavior change;behavior influence;behavioral outcome;Belief;Benchmarking;Cancer Control;Cause of Death;Cigar;cigarette smoking;Code;Collaborations;combustible cigarette;combustible tobacco;Communication;Communication Research;Consumption;cost;cost estimate;Data;Devices;digital;digital health;digital imaging;digital measure;digital media;Dose;electronic cigarette use;electronic cigarette user;Elements;Evaluation;experimental study;Exposure to;Future;Geography;GRP gene;Health;Health behavior change;Health Campaign;Health Care Costs;High School Student;impression;Individual;Industry;Internet;JUUL;Knowledge;Marketing;Mass Media;Measurement;Measures;Media Campaign;member;Methods;Nicotine;novel;Outcome;Participant;Patient Self-Report;Pilot Projects;Predictive Value;Prevalence;prevent;Prevention;Prevention program;preventive intervention;prospective;public education;Public Health;Publishing;Radio;Randomized;randomized trial;Randomized, Controlled Trials;recruit;Reporting;Research;response;Risk Behaviors;Sampling;Science;Smoker;Smoking;social;social media;substance use prevention;Testing;Theoretical model;Time;Tobacco;tobacco advertising;tobacco control;Tobacco Industry;tobacco prevention;tobacco products;Tobacco use;Universities;Washington;Work;young adult;Youth

PROJECT_TITLE: Digital Media for Cancer Control: Randomized Controlled Trial and Dose Response Effects

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Lung;Nanotechnology;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Antibiotic treatment for tuberculosis (TB) is long and arduous and new therapies are urgently needed, especially for drug-resistant TB and HIV-coinfected persons. Host-directed therapies (HDT) that work in conjunction with antibiotic treatment are attractive for improving immunity to TB and anti-TB treatment. We aim to use novel multivalent synthetic nanoparticle antibodies (SNAbs) to specifically target immune cells that suppress immunity and explore their potential as targets for HDT for TB.

PI_NAMEs: RENGARAJAN, JYOTHI  (contact);ROY, KRISHNENDU

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Activities of Daily Living;adaptive immune response;Antibiotic Therapy;Antibiotics;Antibodies;Antimycobacterial Agents;Antitubercular Agents;Antitubercular Antibiotics;Area;arginase;C3HeB/FeJ Mouse;cancer immunotherapy;CD8B1 gene;Cell Physiology;Cells;Cytotoxic T-Lymphocytes;Data;Dioxygenases;Disease;Disease Progression;Drug resistance in tuberculosis;Equilibrium;Genetic Predisposition to Disease;HIV/TB;Immune;immune function;Immune response;Immune Targeting;Immunity;immunoengineering;Immunology;immunomodulatory therapies;immunopathology;Immunosuppression;improved;Inflammation Mediators;Innate Immune Response;innovation;insight;Lung;Macrophage;Malignant Neoplasms;Mediating;Mediator;Monitor;Monoclonal Antibodies;Mus;mycobacterial;Mycobacterium tuberculosis;Myeloid Cells;Myeloid-derived suppressor cells;nanoparticle;nanotherapeutic;Natural Killer Cells;Nitric Oxide Synthase;novel;novel therapeutics;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Persons;Population;prevent;pulmonary granuloma;Pulmonary Pathology;Pulmonary Tuberculosis;Reagent;recruit;Regulatory T-Lymphocyte;Relapse;Research;Resistance;response;Role;S100A8 gene;small molecule inhibitor;Structure of parenchyma of lung;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Time;tool;Treatment Efficacy;Treatment Protocols;Tuberculosis;tuberculosis immunity;tuberculosis treatment;tumor microenvironment;Work

PROJECT_TITLE: Synthetic Nanoparticle-antibody (SNAb) Based Depletion of Myeloid-Derived Suppressor Cells for TB Host-Directed Therapy

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ORG_CITY: SYRACUSE

ORG_DEPT: PHYSICS

ORG_NAME: SYRACUSE UNIVERSITY

PHR: Project Narrative Cell motility is a fundamental process that contributes to building and maintaining tissues as well as diseases such as cancer. This project will determine new mechanisms underlying how cells move through three-dimensional spaces and the role of vimentin intermediate filaments in this process. This study will broaden our understanding of how cells move in physiologically-relevant conditions and its implications for human health and disease.

PI_NAMEs: PATTESON, ALISON ELISE (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: 3-Dimensional;Actins;Address;Adhesions;Cell Communication;cell motility;Cell Nucleus;Cell surface;Cells;cellular resilience;Cytoskeleton;Disease;Embryonic Development;Environment;Extracellular Matrix;F-Actin;Focal Adhesions;Health;Human;Integrins;Intermediate Filament Proteins;Intermediate Filaments;Maintenance;Malignant Neoplasms;Mammalian Cell;Mechanics;Mediating;Microfluidics;Microtubules;migration;Neoplasm Metastasis;Nuclear;Physiological;Play;Polymers;Positioning Attribute;Process;Role;Stress Fibers;Surface;Tissues;Vimentin;wound healing

PROJECT_TITLE: Role of vimentin in mammalian cell motility

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Gene Therapy;Genetics;Immunotherapy;Nanotechnology;Women's Health Research

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE The limited ability to assess CAR T cell infiltration and control their activity within tumors contributes to poor anti- tumor responses against solid malignancies. This proposal seeks to develop an image-guided therapy based on thermal activation of CAR T cells to increase treatment precision and improve patient responses.

PI_NAMEs: EMELIANOV, STANISLAV Y (contact);KWONG, GABRIEL A

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Abbreviations;Adoptive Transfer;Affect;Algorithms;Antitumor Response;Biological Markers;Biological Products;Blood flow;Body Temperature;Breast;Breast Adenocarcinoma;Breast Cancer Cell;Breast Cancer Model;cancer therapy;cancer type;Cancerous;CAR T cell therapy;cell killing;Cell Physiology;Cell surface;Cells;cellular imaging;chimeric antigen receptor;chimeric antigen receptor T cells;clinical care;Contrast Media;cytokine;cytotoxicity;Deposition;design;draining lymph node;engineered T cells;Engineering;ERBB2 gene;Exposure to;Feedback;Focused Ultrasound;Gene Activation;Genetic;Genetic Transcription;Glioblastoma;Glossary;Heating;Hematologic Neoplasms;Histology;Human;Image;image guided;image guided therapy;image processing;imaging platform;imaging system;immune activation;Immune checkpoint inhibitor;immune stimulatory agent;Immunosuppression;improved;In Vitro;in vivo;Infiltration;Injections;Interleukin-15;Label;Liquid substance;lymph nodes;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Maps;Metastatic Neoplasm to Lymph Nodes;Modeling;Monitor;Morphology;mouse model;nanoGold;nanoparticle;nanorod;neoplastic cell;Optics;overexpression;Oxygen;patient response;Patients;photoacoustic imaging;Population;Precision therapeutics;preclinical evaluation;Primary Neoplasm;Production;programs;Proliferating;Recurrence;response;response biomarker;Safety;safety assessment;Sarcoma;Shapes;Site;Solid;Solid Neoplasm;success;Switch Genes;System;systemic toxicity;T cell infiltration;T cell therapy;T-Cell Proliferation;T-Cell Receptor;T-Cell Transformation;T-Lymphocyte;Temperature;Testing;Therapeutic;therapeutic gene;Time;Tissues;Toxic effect;trafficking;transgene expression;Transgenes;Transgenic Mice;Translating;treatment response;tumor;Tumor Markers;tumor microenvironment;Ultrasonography;ultrasound

PROJECT_TITLE: Image-guided cancer therapy using heat activatable CAR T cells

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_DEPT: OTOLARYNGOLOGY

PHR: PROJECT NARRATIVE We will establish our human temporal bone laboratory as a national technological resource for the auditory and vestibular research community. Our highly specialized team of researchers and technical specialists will provide necessary materials and services, processing innovations, training, and outreach for scientists and technicians. The integration of our resources with a nationwide network will promote progress in understanding the cellular and molecular mechanisms, prevention, and treatment of ear diseases.

PI_NAMEs: ADAMS, MEREDITH EVELYN;CUREOGLU, SEBAHATTIN  (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Address;Affect;Anatomy;Archival Collection;Auditory;Autopsy;Awareness;Biological;Bone Tissue;Clinical;Clinical Research;Collaborations;Collection;Communities;Consumption;cost;Course Content;Databases;Decalcification;Dedications;design;digital repositories;Disease;DNA;Drug or chemical Tissue Distribution;Ear;Ear Diseases;Education;Education and Outreach;Equilibrium;experience;Genomics;Genotype;Goals;Hearing;Human;Human Resources;Hybrids;Image;image processing;imaging facilities;improved;innovation;Instruction;inter-institutional;interest;Investigation;Knowledge;Laboratories;Lasers;Learning Module;medical specialties;meetings;Methods;Microtomy;Molecular;multidisciplinary;Multimedia;National Institute on Deafness and Other Communication Disorders;Newsletter;outreach;Pathology;Persons;Phenotype;Preparation;preservation;Prevention;Procedures;Process;programs;Proteins;Protocols documentation;Publications;Registries;Research;Research Personnel;Resources;RNA;sample fixation;Scholarship;Scientist;Services;Site;skills;social media;Source;Specialist;Specimen;Speed;Structure;Techniques;Technology;Temporal bone structure;Testing;Time;tissue processing;Tissues;Training;training opportunity;Universities;Vestibular Function Tests;vestibular system;virtual;Visualization;web site;Work

PROJECT_TITLE: Resource Center for Human Temporal Bone Research, Innovation, and Education


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Immunotherapy;Infectious Diseases;Neurosciences;Rare Diseases;Tuberculosis

PHR: Project Narrative This project seeks to characterize the immune system response in spinal fluid to TB meningitis. This work will improve our understanding of the causes of TB meningitis and how the human immune response contributes to the disease. The overall objective is to enable better medical care for persons with TB meningitis, by enabling better diagnosis and potential customized host direct immune therapies.

PI_NAMEs: BOULWARE, DAVID R (contact);MEYA, DAVID BISAGAYA

PROJECT_TERMS: Acid Fast Bacillae Staining Method;Acquired Immunodeficiency Syndrome;Address;Adrenal Cortex Hormones;Adult;Africa South of the Sahara;AIDS related cancer;Anti-Inflammatory Agents;Autopsy;Bacillus;Bacteria;Biological;biomarker identification;Brain;Caring;Cell Lineage;Cells;Cerebrospinal Fluid;Cessation of life;Characteristics;chemokine;Clinical;clinical care;Clinical Research;Clinical Trials;Color;CXCR3 gene;cytokine;Data;Diagnosis;Diagnostic Sensitivity;Diagnostic tests;Disease;Disease Outcome;Dose;Enrollment;experience;Flow Cytometry;follow-up;high risk;HIV;HIV Seronegativity;Human;Immune;immune activation;immune function;Immune response;Immunity;immunodeficiency;Immunologics;Immunology;immunomodulatory therapies;Immunotherapy;improved;Infection;Infection Control;Inflammation;Inflammatory Response;innovation;Interferons;Interleukin-6;Knowledge;Medical;Meningeal Tuberculosis;Meningitis;Methodology;Methods;Microscopy;Minnesota;Morbidity - disease rate;mortality;Mycobacterium tuberculosis;Neurocognitive;neurocognitive test;neutrophil;Oral;Outcome;Pathogenesis;Pathologic;Patients;Persons;Pharmacotherapy;Phase;phase II trial;phase III trial;Phenotype;Play;prospective;Publishing;randomized, clinical trials;recruit;Research;Research Infrastructure;response;Rifampin;Sampling;Site;skills;Specimen;Steroids;survival outcome;T-Lymphocyte;targeted treatment;Testing;Tissues;TNF gene;trafficking;Translational Research;treatment optimization;treatment response;Tuberculosis;Tuberculous Pericarditis;Uganda;Vulnerable Populations;Work

PROJECT_TITLE: TB Meningitis: Evaluating CSF Immunology to Discover Hidden Disease and Potential Immunomodulatory Therapies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-T(90)]


NIH_SPENDING_CATS: Clinical Research;Hematology;Kidney Disease;Prevention;Rare Diseases;Sickle Cell Disease

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Sickle cell disease is among the most common monogenetic diseases worldwide and chronic kidney disease, which occurs in more than half of adults with sickle cell disease, is associated with high mortality. The goals of this proposal are to identify mechanisms for how cell-free hemoglobin mediates kidney damage in sickle cell disease. Findings from this proposal will facilitate future development of interventional strategies to prevent and treat sickle nephropathy.

PI_NAMEs: SARAF, SANTOSH  (contact)

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;Address;Adult;Affect;African American population;Animal Model;Award;Binding;Binding Proteins;Biological Markers;Blood Vessels;Caring;Catabolism;Cells;Cessation of life;Chicago;Chronic Kidney Failure;Circulation;Complement Activation;contrast enhanced;Creatinine;Data;Disease;Disease Progression;disorder risk;Endothelial Cells;Endothelium;Environment;Enzymes;Exposure to;Functional disorder;Future;Gene Expression Profile;genetic analysis;Goals;Haptoglobins;Health;Heme;heme oxygenase-1;Hemoglobin;hemoglobin polymer;Hemoglobinuria;Hemolysis;Hemolytic-Uremic Syndrome;high risk;high risk population;Histologic;Illinois;Impairment;improved;Injury to Kidney;innovation;insight;Institution;Intervention;Kidney;kidney cell;kidney cortex;Kidney Diseases;Mediating;Metabolism;Microvascular Dysfunction;Morbidity - disease rate;mortality;Mus;novel;Oral;Organ;oxidative damage;Oxidative Stress;Pathway interactions;Patients;Persons;Phenotype;Plasma;Plasma Cells;Positioning Attribute;Pre-Eclampsia;Predisposition;prevent;Preventive;Process;Productivity;Protein C;Proteins;rat KIM-1 protein;Recording of previous events;renal damage;Renal function;Research;research study;Risk;Role;Sepsis;Serum;Sickle Cell;Sickle Cell Anemia;Sickle Hemoglobin;sickling;small molecule inhibitor;Tandem Repeat Sequences;Testing;Therapeutic;therapy development;Thrombomodulin;Time;Toxic effect;Transgenic Organisms;Translational Research;ultrasound;Universities;Urine;Variant;Vascular Diseases;vascular endothelial dysfunction;vaso-occlusive crisis

PROJECT_TITLE: Pathways of Cell-Free Hemoglobin in Sickle Cell Nephropathy

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ORG_CITY: Newark

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Project Narrative Small secreted extracellular vesicles play a critical role in communication between cells during physiological processes, cancer progression, and neurodegenerative diseases. The proposed research will provide new insights into how an individual cell packages and releases distinct populations of extracellular vesicles.

PI_NAMEs: TANIS, JESSICA E (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Afferent Neurons;Animal Behavior;Animal Communication;animal imaging;Animals;Biogenesis;Biological Markers;Biological Models;Body Fluids;Caenorhabditis elegans;Calcium;Candidate Disease Gene;Cell membrane;cell type;Cells;Cellular Stress;Chimeric Proteins;Cilia;Classification;Communication;Comprehension;Confocal Microscopy;Cultured Cells;Data;Defect;Detection;Development;Disease;Endocytosis;Engineering;Environment;Exclusion;exosome;extracellular vesicles;Flow Cytometry;Genetic;genetic approach;Goals;Hermaphroditism;Heterogeneity;Homeostasis;Image;Imaging Techniques;in vivo;Individual;insight;intercellular communication;interest;Investigation;Ion Channel;Kinesin;Label;Lateral;Lipid Bilayers;Lipids;macromolecule;male;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Membrane;Microscopy;microvesicles;Modeling;Molecular;Morphology;Multivesicular Body;mutant;Neurodegenerative Disorders;Neurons;novel;Pathologic;Phospholipids;Physiological;Physiological Processes;Play;Population;Population Heterogeneity;prevent;Proteins;Research;Resolution;RNA;Role;Site;Sorting;Stimulus;Structure;System;Techniques;Testing;Therapeutic;Time;Tissues;Transgenic Animals;Transmission Electron Microscopy;tumor progression;Vesicle;vesicular release;Visualization;Work

PROJECT_TITLE: Elucidating biogenesis and cargo sorting mechanisms for discrete extracellular vesicle subpopulations in C. elegans

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Although HIV infection can be controlled by daily lifelong adherence to expensive antiretroviral ARV therapies, it cannot presently be cured. Reducing the reservoirs of virus that persist in a people on ARV therapy may lead to long-term remission without the need for ongoing medication. This proposal aims to meet this need by identifying mechanisms by which HIV infected cells are able resist elimination by the immune system, setting the stage for future clinical trials aimed at achieving remission or cure of HIV.

PI_NAMEs: JONES, R. BRAD  (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Adherence;Advanced Development;Agonist;antagonist;Anti-Retroviral Agents;antiretroviral therapy;Applications Grants;arm;Autologous;BCL1 Oncogene;Biological Assay;Biology;Candidate Disease Gene;candidate identification;CD4 Positive T Lymphocytes;Cell Culture Techniques;cell killing;Cell Survival;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cessation of life;Clinical Trials;Clone Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Consultations;Cytotoxic T-Lymphocytes;Data;differential expression;Disease remission;Dissection;effector T cell;Enabling Factors;EZH2 gene;Future;Gene Expression Profiling;Genes;Genetic Transcription;Goals;Granzyme;Health;HIV;HIV Infections;Human;immune clearance;Immune system;Immunotherapy;Impairment;improved;in vitro Model;in vivo;Individual;Infection;insight;Intrinsic factor;Letters;Leukapheresis;Literature;Malignant Neoplasms;Mediating;Microscopy;Modernization;next generation sequencing;novel;novel therapeutics;Outcome;overexpression;Pathway interactions;Persons;Pharmaceutical Preparations;Phenotype;Play;Predisposition;Reporting;Resistance;resistance factors;resistance gene;resistance mechanism;Resolution;Resource-limited setting;Resources;Role;Sampling;Sampling Studies;Serine Proteinase Inhibitors;small molecule;targeted treatment;Technology;Testing;Therapeutic;therapeutic candidate;therapeutic target;therapy development;Treatment Efficacy;Validation;Viral reservoir;Virus;Work

PROJECT_TITLE: Mechanisms of CTL Resistance in HIV Reservoirs

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Estrogen;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Urologic Diseases;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Bladder cancer, one of the most common genitourinary malignancies, is a highly sex-biased disease that disproportionately affects males. In this proposal, we aim to shed new light on the overlooked and largely undefined epigenetic basis of observed sex differences, as they remain largely undefined. Our expected findings will catalyze the identification of sex-biased genes and regulatory elements for the design of sex-specific bladder cancer screening and treatment.

PI_NAMEs: LI, XUE SEAN (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Address;Affect;Androgen Receptor;Androgens;Bacterial Artificial Chromosomes;Biological;Biological Availability;biological sex;Biology;Bladder;Bladder Neoplasm;cancer type;carcinogenesis;Chemicals;Chromatin;Clinical;conditional knockout;Data;design;Development;Disease;Disproportionately impacts women;Down-Regulation;Environmental Risk Factor;Epigenetic Process;epigenome;Exhibits;Female;Four Core Genotypes;Future;gain of function;Gene Expression;Gene Expression Regulation;Gene Family;Gene Targeting;Genes;Genitourinary system;Glucuronosyltransferase;Gonadal Hormones;Gonadal Steroid Hormones;Gonadal structure;histone methylation;Histones;Hormonal;Human;improved;in vivo;Incidence;Infection;Investigation;Knockout Mice;Lead;Libido;Link;Lysine;male;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Measures;Mediating;men;Modeling;mortality;multiple omics;Mus;mutant;Mutation;novel;occupational hazard;Oncogenes;Outcome;Ovary;Pathway interactions;Patients;Physiological;prevent;Regulation;Regulatory Element;Reporting;Repression;Risk Factors;Role;Screening for cancer;sex;sex as a biological variable;Sex Bias;Sex Chromosomes;Sex Differences;sex disparity;sexual dimorphism;Shapes;Smoking;success;System;Technology;Testing;Testis;transcription factor;transcriptome;Transgenic Mice;tumor;Tumor Biology;Tumor Suppressor Genes;Tumor Suppressor Proteins;tumorigenesis;UGT1A1 gene;Uridine;Urothelium;Woman;X Chromosome;XX male;XY females

PROJECT_TITLE: Sexual Dimorphism in Bladder Cancer

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_DEPT: NEUROSCIENCES

PHR: PROJECT NARRATIVE The Minnesota Inclusive Neuroscience Development Scholars (MINDS) doctoral readiness program will provide recent baccalaureates from diverse backgrounds with research experience related to the neuroscience of drug abuse, as well as courses for skill development. These research education activities will support participants in making a successful transition into research-focused doctoral degree programs, and provide preparation for a career in biomedical research.

PI_NAMEs: DUKES, ANGELINE JOAN;LEMOS, JULIA C;MERMELSTEIN, PAUL G (contact);ROTHWELL, PATRICK

PROGRAM_OFFICER_NAME: HOLMES, ANGELA L

PROJECT_TERMS: addiction;Advocacy;Authorship;Biological Sciences;Biomedical Research;career;career development;catalyst;Center Core Grants;Collaborations;college;Communication;Communities;Competence;Complement;Country;Data;Degree program;design;Development;disadvantaged background;Doctor's Degree;Drug abuse;Drug Addiction;Education Projects;education research;Educational Activities;Educational Status;empowerment;Engineering;Enrollment;Ensure;Environment;equity, diversity, and inclusion;Evaluation;Exercise;Expenditure;experience;Experimental Designs;Extramural Activities;Faculty;faculty mentor;Funding;Goals;Graduate Education;graduate school;Growth;Individual;Infrastructure;innovation;Institution;Instruction;Journals;Laboratories;Laboratory Research;Learning Skill;marginalized community;marginalized population;Medical;meetings;Mentors;Mentorship;Methods;Minnesota;Mission;National Institute of Drug Abuse;neighborhood disadvantage;Neurosciences;next generation;Outcome;Participant;Phase;Postbaccalaureate;posters;Preparation;Professional Competence;programs;Publications;Readiness;recruit;Research;Research Personnel;Research Project Grants;Research Support;Resources;response;responsible research conduct;scaffold;Scholars Program;Science;Series;skill acquisition;skills;Structure;success;symposium;Teacher Professional Development;Technical Expertise;Technology;Training;Training Programs;translational scientist;Universities


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Headaches;Hypertension;Neurosciences;Pain Research;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: LOUISVILLE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Narrative Both bladder and bowel distention have been identified as primary triggers of autonomic dysreflexia in individuals with spinal cord injury, a sudden sharp rise in blood pressure with intolerable symptoms such as pounding headache and/or chills. We have recently documented as part of our current R01 this massive unmodulated sympathetic reflex which causes widespread vasoconstriction (presenting as severe hypertension) as a limitation for bladder capacity in numerous research participants. The goals of the current multi-disciplinary study incorporating intersystem interactions are 1) to investigate in a controlled laboratory setting and then with mobile at-home monitoring the extent, severity and frequency of occurrence of autonomic dysreflexia with respect to daily bladder and bowel function, in conjunction with identifying potential underlying mechanisms by examining urinary biomarkers for several specific vasoactive hormones, and 2) to regulate cardiovascular function therapeutically as part of bladder and bowel management using spinal cord epidural stimulation.

PI_NAMEs: HARKEMA, SUSAN J;HUBSCHER, CHARLES H. (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TITLE: Effects of activity dependent plasticity on recovery of bladder and sexual function after human spinal cord injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-B(90)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Digestive Diseases;Emerging Infectious Diseases;Genetics;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative The proposed research seeks to advance the search for direct acting antiviral drugs for use in combatting COVID-19 through analysis of the SARS CoV-2 RNA-dependent RNA polymerase to define the kinetics of incorporation of canonical and mismatched nucleotides and nucleotide analogs. In addition, the kinetics and mechanism of nucleotide excision by the 3'- 5' proofreading exonuclease will be measured to establish the contribution of the exonuclease to overall fidelity and discrimination against nucleotide analogs. These studies will provide the basis for evaluating the overall fidelity of CoV-2 RNA replication and for testing and advancing the clinical effectiveness of nucleotide analogs used to slow the rates of CoV- 2 viral replication, thereby addressing the pressing need to combat COVID-19.

PI_NAMEs: JOHNSON, KENNETH ALLEN (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;acute infection;Address;analog;Anti-viral Agents;base;Base Pair Mismatch;Base Pairing;Biochemical;Biological Assay;Catalytic RNA;Clinical effectiveness;Clinical Trials;combat;Combination Drug Therapy;Combined Modality Therapy;Complement;Complex;Coronavirus;COVID-19;COVID-19 pandemic;COVID-19 therapeutics;COVID-19 treatment;Cryoelectron Microscopy;Data;design;Development;Discrimination;DNA-Directed DNA Polymerase;Drug usage;Effectiveness;Event;Excision;Exonuclease;experience;Foundations;Future;Genome;Goals;Hepatitis C;Hepatitis C virus;HIV;HIV/HCV;Human;Hydrolysis;Immunity;improved;inhibitor;innovation;Kinetics;Knowledge;Laboratories;Logic;Measurement;Measures;Methods;Mitochondrial DNA;mutant;nucleoside analog;nucleotide analog;Nucleotides;Pharmaceutical Preparations;Play;Polymerase;polymerization;Polymers;Probability;Proteins;reconstitution;remdesivir;Research;RNA;RNA Degradation;RNA primers;RNA replication;RNA-Directed DNA Polymerase;RNA-Directed RNA Polymerase;Sampling;SARS coronavirus;Site;sound;Specificity;structural determinants;Structure;Testing;Therapeutic;Thermodynamics;Translating;Vaccines;vector;Viral;viral RNA;Virus Inhibitors;Virus Replication;Work;Workplace

PROJECT_TITLE: Kinetic and structural basis for SARS-CoV-2 RNA-dependent RNA polymerase specificity and inhibition

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Esophageal Cancer;Rare Diseases;Tobacco

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Esophageal diseases are major health problems in the U.S. and throughout the world. The cells that line the esophagus are exposed daily to irritants such as cigarette smoke and alcohol. Here, we propose to define the protective mechanisms by which esophageal cells respond to such damaging agents and the factors that disrupt these protective responses, leading to esophageal diseases.

PI_NAMEs: KATZ, JONATHAN P (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Address;Alcohols;Apoptosis;BAX gene;BCL2 gene;Binding;Cancer Etiology;carcinogenesis;Cell Cycle Arrest;Cell Fate Control;Cell Line;cell transformation;Cells;Cessation of life;cigarette smoke;Critical Pathways;cytokine;Cytoprotection;Data;Development;Disease;DNA Sequence Alteration;environmental stressor;Epithelial Cells;Epithelium;Esophageal Diseases;Esophageal mucous membrane;Esophageal Squamous Cell;esophageal squamous cell cancer;Esophagus;Event;Exposure to;Genetic Transcription;genome-wide;Genotoxic Stress;genotoxicity;Health;Homeostasis;Human;Individual;Inflammation;Inflammatory;Injury;Irritants;keratinocyte;Kruppel-like transcription factors;Malignant - descriptor;Malignant neoplasm of esophagus;Malignant Neoplasms;Mediating;migration;Molecular;mouse model;mutant;Mutate;Mutation;Neoplasms;Outcome;Pathway interactions;Pattern;physiologic stressor;Physiological;Play;prevent;Proliferating;Proto-Oncogene Proteins c-akt;Regulation;Regulatory Pathway;repaired;response;response to injury;Smoke;Smoking;Squamous Epithelium;Stress;stressor;Testing;three dimensional cell culture;three-dimensional modeling;Tobacco;TP53 gene;tumor progression;Tumor Suppressor Proteins;ultraviolet irradiation

PROJECT_TITLE: Cytoprotective pathways in esophageal squamous epithelia

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]