FUNDING_MECHANISM: RESEARCH CENTERS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: NARRATIVE — JHU TRAC OVERALL To make further progress in efforts to achieve the World Health Organization’s END TB goals, additional innovative, cross-disciplinary and impactful research is critical and a new generation of TB scientists must be recruited and trained. The Johns Hopkins University (JHU) TB Research Advancement Center (TRAC) will provide added value to TB researchers at JHU by bringing together highly experienced researchers across multiple disciplines and representing four JHU schools (Medicine, Public Health, Nursing and Engineering) in order to optimize training opportunities for junior investigators and support for new, interdisciplinary collaborations, with the goal of addressing critical knowledge gaps in TB research.

PI_NAMEs: CHAISSON, RICHARD E.;KARAKOUSIS, PETROS C (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Acceleration;Address;animal imaging;Animal Model;Area;Baltimore;Basic Science;Bioinformatics;Biological Assay;Biometry;biosafety level 3 facility;Biostatistics Core;career;Cessation of life;Clinical;Clinical Pharmacology;Clinical Research;clinical research site;Clinical Sciences;Clinical Trials;Collaborations;community engagement;Computer Models;Cost Effectiveness Analysis;Country;Data;design;Development;Diagnosis;Diagnostic;diagnostic tool;Discipline;Discipline of Nursing;Disease;drug development;Economic Models;Effectiveness;efficacy validation;Engineering;Ensure;Epidemic;epidemiological model;Epidemiology;evidence base;experience;Funding;Generations;global health;Goals;Government;Health;Health Services Accessibility;HIV/TB;Image;imaging facilities;Immunology;improved;In Vitro;innovation;interdisciplinary collaboration;Interdisciplinary Study;Intervention;Knowledge;Laboratories;large datasets;mathematical model;Medicine;meetings;member;Mentors;microbial;Microbiology;Mission;Modeling;multidisciplinary;Mycobacterium tuberculosis;next generation;novel;novel diagnostics;Output;outreach;pandemic disease;Participant;Pathogenesis;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pharmacology;Pharmacology Study;pharmacometrics;Policies;Population Dynamics;pre-clinical;Prevention;Productivity;Protocols documentation;Public Health;public health intervention;radiotracer;recruit;Research;Research Personnel;research study;Role;Sampling;Schools;Scientist;Services;Site;Specific qualifier value;Strategic Planning;Sum;symposium;synergism;Talents;tool;Training;training opportunity;Training Programs;translational model;Translational Research;Tuberculosis;tuberculosis treatment;Underrepresented Populations;United States National Institutes of Health;Universities;World Health Organization

PROJECT_TITLE: JHU TRAC: Training and Supporting the Next Generation of TB Researchers


ADMINISTERING_IC: AI

ARRA_FUNDED: N

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_STATE: MD

PI_NAMEs: KARAKOUSIS, PETROS C (contact)

PROJECT_TERMS: Advisory Committees;analytical tool;Award;Benchmarking;Budgets;career development;Clinical Research;Collaborations;Committee Members;Communication;Communities;community advisory board;Data;Development;Educational workshop;Electronics;Ensure;experience;FAIR principles;Feedback;Fostering;Funding;Future;Goals;Grant;Health;Individual;Infrastructure;innovation;Institution;interdisciplinary collaboration;Measures;Medical;meetings;member;Mentors;Mentorship;Methodology;Mission;Monitor;National Institute of Allergy and Infectious Disease;Newsletter;next generation;novel;Office of Administrative Management;Output;Performance;Productivity;programs;Protocols documentation;Publications;recruit;Research;Research Personnel;Research Project Grants;Resources;Schedule;Schools;Scientist;Series;Services;Strategic Planning;Sum;Supervision;Surveys;synergism;Training;training opportunity;Training Programs;Translational Research;Tuberculosis;Underrepresented Populations;United States National Institutes of Health;Universities;web site;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Genetically engineered mouse models provide a tractable system for studying human development and disease, fueling discoveries that can dramatically improve public health. The MMRRC-UNC imports, archives and distributes mouse strains to the scientific community to protect and provide efficient access to this valuable resource. In addition, the MMRRC-UNC has developed synergistic research projects to support rigor and reproducibility of biomedical research using mouse models.

PI_NAMEs: MAGNUSON, TERRY R (contact)

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Acceleration;Address;Agreement;Animal Model;Applied Research;Archives;Biocompatible Materials;Biomedical Research;California;Caring;Cell Separation;Clinical;Cloning;Code;Collaborations;Communities;complement resource;computerized tools;cost;Cryopreservation;Data;Deposition;Derivation procedure;Development;disease model;Embryo;embryo cryopreservation;embryonic stem cell;Ensure;Environment;Fee-for-Service Plans;Funding;Gene Targeting;Genes;Genetic;Genetic Engineering;Genetic Research;Genetically Engineered Mouse;Genome;Genomics;Genotype;Germ;Germ Cells;Goals;gut microbiome;Health;high risk;high standard;Human;Human Development;human disease;improved;Individual;Informatics;insight;International;Investments;Knock-out;Maintenance;Marketing;meetings;member;Methods;Mission;Missouri;Modeling;Mouse Embryonic Stem Cells;mouse genetics;mouse model;Mouse Strains;Mus;Mutagenesis;Mutant Strains Mice;Names;new technology;North Carolina;pathogen;Phenotype;Policies;preservation;Procedures;Process;programs;Proteins;Protocols documentation;Public Health;Quality Control;repository;Reproducibility;Research;Research Personnel;Research Project Grants;Resources;Role;Scientist;Services;sperm cell;Study models;synergism;System;Technology;Testing;Transgenic Organisms;United States;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: A Carolina Center to Characterize and Maintain Mutant Mice

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-C(50)]


NIH_SPENDING_CATS: Biotechnology;Genetics

PHR: Project Narrative (Resource)- do not complete according to PAR-19-175.

PROJECT_TERMS: Animal Model;Archives;Clinical;Code;Collection;computerized tools;Core Facility;cost;Cryopreservation;Derivation procedure;Embryo;Ensure;Environment;Fibroblasts;Foundations;Gene Expression;gene interaction;gene-editing approach;Genes;Genetic;genetic manipulation;genetic resource;Genetic Variation;Genetically Engineered Mouse;Genome;Genomics;Goals;high standard;Home;Human;Human Biology;human disease;improved;Inbred Mouse;Inbreeding;Individual;induced pluripotent stem cell;Infrastructure;innovation;insight;Institution;International;Investments;Knock-out;knockout gene;Knockout Mice;Laboratories;Laboratory mice;Maintenance;Mission;Modeling;mouse genetics;mouse genome;Mouse Strains;Mus;Mutagens;Mutant Strains Mice;Nobel Prize;North Carolina;personalized approach;Phenotype;Physiological;Population;Procedures;Proteins;Recombinants;Reproducibility;Research;Research Personnel;Resources;Role;Solid;sperm cell;Standardization;Study models;synergism;System;Technology;United States;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Resource Section - Core 001

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-C]


NIH_SPENDING_CATS: Infectious Diseases;Prevention

PI_NAMEs: GOLUB, JONATHAN E. (contact)

PROJECT_TERMS: Accountability;Address;Adherence;Applications Grants;Area;Arts;Award;Basic Science;Bioinformatics;career;career development;clinical investigation;Clinical Research;co-infection;Collaborations;Communities;community based participatory research;comorbidity;cost effectiveness;Dedications;Development;Discipline;Discipline of Nursing;Educational workshop;Engineering;Faculty;FAIR principles;Feedback;Funding;Future;Goals;Grant;Grant Review;Health;Health Services Accessibility;high risk;Human;Immunologist;implementation science;Individual;Infection Control;Infection prevention;innovation;interest;Investments;K-Series Research Career Programs;Knowledge;Leadership;medical schools;meetings;Mentors;Mentorship;Methodology;mHealth;Mission;Modeling;molecular diagnostics;multidisciplinary;next generation;novel;novel strategies;Nursing Models;Outcomes Research;Pathogenesis;Prevention;Productivity;programs;Public Health;recruit;Research;Research Methodology;Research Personnel;Research Priority;Resources;Science;Scientist;Series;skills;Study Section;Systems Biology;therapeutic vaccine;Training;training opportunity;Translations;Universities;Work;Writing

PROJECT_TITLE: Developmental Core


NIH_SPENDING_CATS: Genetics

PHR: Project Narrative (Research)- do not complete according to PAR-19-175.

PI_NAMEs: PARDO-MANUEL DE VILLENA, FERNANDO  (contact)

PROJECT_TERMS: Address;analysis pipeline;Animal Model;Applied Research;Awareness;Biomedical Research;Cell Line;Clinical;Code;Collection;Communities;Complement;computerized tools;congenic;cost;cost effective;Cryopreservation;Data;Databases;Derivation procedure;design;Development;disease model;Ensure;Environment;Environmental Impact;Epigenetic Process;Experimental Designs;experimental group;experimental study;Genes;Genetic;genetic analysis;genetic makeup;Genetic Models;Genetically Engineered Mouse;Genome;Genomics;Genotype;Germ Cells;Goals;high standard;Human;human disease;improved;Inbreeding;Individual;Infrastructure;innovation;insight;interest;International;Investments;Knock-out;Link;Maintenance;Measures;microbiome;Mission;Modeling;mouse genetics;mouse model;Mouse Strains;Mus;Mutant Strains Mice;Nature;next generation;nutrition;Phenotype;Procedures;Proteins;Publications;Publishing;Reporting;Reproducibility;Reproducibility of Results;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Resources;Role;Sampling;Services;Speed;Standardization;Study models;success;support tools;synergism;System;Technology;tool;United States National Institutes of Health;Update;Validation;Variant;web site;web-accessible;Work

PROJECT_TITLE: Applied Research - Project 1


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PUBLIC HEALTH RELEVANCE: Malfunctioning of protein N-terminal methyltransferases is closely associated with various human diseases. We propose a series of chemical biology strategies to elucidate the mechanism, inhibition, and functions of protein α-N-terminal methylation. This effort is of great significance to understand basic biological processes of protein α-N-terminal methylation, which may ultimately lead to novel therapeutic approaches and targets for cancer, aging, and other diseases.

PI_NAMEs: HUANG, RONG  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Affect;Aging;aging process;analog;Arginine;ATP phosphohydrolase;Biological;Biological Process;Biology;Carbamates;Cells;Cellular Stress;centromere protein A;Ceramide glucosyltransferase;Chemicals;Chromatin;Chromosome Condensation;Complex;Data;Defect;Development;Developmental Process;Disease;DNA Damage;DNA Repair;DNA-Binding Proteins;experience;Goals;Guanosine Triphosphate Phosphohydrolases;high throughput screening;Histones;Human;human disease;improved;infancy;inhibitor;interdisciplinary approach;Kinetics;Knock-out;Knockout Mice;Knowledge;Ligation;Lysine;Malignant Neoplasms;Mediating;Methylation;Methyltransferase;Mitosis;Modification;Molecular;Molecular Chaperones;Myosin Alkali Light Chains;N-terminal;novel;novel therapeutic intervention;Oncoproteins;Pathway interactions;Peptide Elongation Factor 1;Peptides;Phenotype;Play;Poly(ADP-ribose) Polymerases;Premature aging syndrome;programs;protein function;Protein phosphatase;Proteins;Proteomics;public health relevance;Quinuclidines;Reporting;Research;Retinoblastoma;Roentgen Rays;Role;Series;small molecule inhibitor;Specificity;Speed;Structure;Substrate Specificity;success;template activating factor-I;Therapeutic;tool;transcriptomics;Translations;tumorigenesis;Up-Regulation;Work

PROJECT_TITLE: Protein N-terminal Methylation Mechanisms and Inhibition

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biomedical Imaging;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

PI_NAMEs: BISHAI, WILLIAM RAMSES (contact)

PROJECT_TERMS: Accountability;animal breeding;Animal Housing;animal imaging;Animal Model;Animals;Basic Science;Biological;Breeding;Cavia;Clinic;clinically relevant;co-infection;Computer software;cytokine;Data;Data Analyses;data sharing;Data Storage and Retrieval;Dedications;Disease;Environmental Exposure;Equipment;experience;Faculty;FAIR principles;Feedback;Flow Cytometry;Goals;Grant;Histopathology;HIV/TB;Hormones;Image;imager;imaging approach;Imaging Device;imaging study;Immune response;Immunologics;Immunology;implantation;in vivo imaging;Infection;Inflammation;Infrastructure;Institution;Laboratories;laboratory equipment;Leadership;Measurement;meetings;Mentors;metabolomics;Methodology;Methods;Microbiology;Mission;Modeling;Molecular Genetics;Mus;Mycobacterium tuberculosis;next generation;novel;Oryctolagus cuniculus;Outcome Measure;Pathogenesis;Persons;Positron-Emission Tomography;pre-clinical;preclinical study;Predisposition;Preparation;primary endpoint;Privatization;Procedures;programs;Protocols documentation;radiotracer;reconstruction;Research;Research Personnel;research study;Resolution;response;Scanning;Schedule;Series;Services;Sex Differences;single photon emission computed tomography;single-cell RNA sequencing;Site;Span 20;Speed;Standardization;synergism;Techniques;Technology;Tissue Sample;tool;Training;training opportunity;Translating;Tuberculosis;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Microbiology, Immunology, Animal Modeling and Imaging


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: INDIANAPOLIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: Project narrative The parasite Toxoplasma gondii infects nearly a third of the word population and can lead to severe disease and even death in immunocompromised individuals and those infected congenitally. This parasite possesses a single mitochondrion that is essential for its survival and interestingly changes shape as the parasite goes from cell to cell. Our research aims at identifying the proteins and processes that control the shape of the mitochondrion, which will reveal new ways to target the mitochondrion as a way to combat toxoplasmosis.

PI_NAMEs: ARRIZABALAGA, GUSTAVO A (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Address;Affect;Amino Acids;Apical;Apicomplexa;Automobile Driving;Auxins;Biochemistry;Biological Assay;Biology;Biotinylation;Calcium;Cells;Cessation of life;Co-Immunoprecipitations;combat;Complex;Coupling;Cytokinesis;daughter cell;Development;Disease;domain mapping;Drug Targeting;Economic Burden;Environment;experimental study;extracellular;Health;Homeostasis;human pathogen;Image;Immunocompromised Host;In Vitro;in vivo;Individual;Knock-out;Lasso;Life;Life Cycle Stages;Light;Lipids;Lytic Phase;Mechanics;Mediating;Membrane;Microscopy;Mitochondria;Molecular;Molecular Genetics;Monitor;Morphology;mutant;Mutation Analysis;novel;novel therapeutics;Organelles;Parasites;pathogen;Pharmaceutical Preparations;Phenotype;Phosphorylation Site;Physiology;Plasmodium falciparum;Play;Population;Positioning Attribute;Post-Translational Protein Processing;Process;protein complex;Proteins;Proteomics;Regulation;Research;Resistance;Role;segregation;Shapes;Site;Societies;Stretching;Structure;System;tissue culture;Toxoplasma;Toxoplasma gondii;Toxoplasmosis;Transmembrane Domain;Tubular formation;yeast two hybrid system;Yeasts

PROJECT_TITLE: Regulation of mitochondrial morphodynamics in Toxoplasma gondii

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-M(02)M]


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease;Microbiome;Nutrition;Prevention

PROJECT_TERMS: Address;Affect;Animal Model;Applied Research;Assessment tool;Biological Markers;Biomedical Research;chromatin remodeling;Clinical;Code;Colitis;Communities;Complement;computerized tools;cost;Cryopreservation;Data;Derivation procedure;Development;Diet;disease model;DNA Methylation;Enhancers;Ensure;Environment;Environmental Risk Factor;Enzymes;Epigenetic Process;epigenome;experimental study;gene environment interaction;Genes;Genetic;Genetically Engineered Mouse;Genome;Genomic Segment;Genomics;Gnotobiotic;Goals;high standard;Histones;Human;human disease;Hybrids;improved;Individual;Inflammatory;Infrastructure;innovation;insight;Institution;International;Investments;Knock-out;Macronutrients Nutrition;Maintenance;Measures;Microbe;microbiome;microbiota;Micronutrients;Mission;Modeling;mouse genetics;mouse model;Mouse Strains;Mus;Mutant Strains Mice;Pathogenesis;Phenotype;Procedures;Proteins;Reducing diet;repository;Reproducibility;Research;Research Personnel;Research Project Grants;Resources;Role;SMARCA4 gene;sperm cell;sperm cryopreservation;sperm quality;Spontaneous colitis;Study models;synergism;Technology;United States National Institutes of Health;Work

PROJECT_TITLE: Applied Research - Project 2


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

PI_NAMEs: NUERMBERGER, ERIC L (contact)

PROJECT_TERMS: Acceleration;Accountability;Adherence;Analytical Chemistry;analytical method;assay development;Award;Biological;Biological Assay;Blood;career;Cerebrospinal Fluid;Clinical;clinical care;Clinical Data;Clinical Pharmacology;Clinical Research;Collaborations;Data Analyses;Decision Making;demographics;design;Development;Dose;drug development;Drug Evaluation;Drug Interactions;Drug Kinetics;Drug usage;Dryness;early phase clinical trial;Education;Elements;Environment;Environmental Risk Factor;Evaluation;experience;FAIR principles;Fostering;Genetic;Goals;good laboratory practice;Hair;Human Milk;Human Resources;Individual;innovation;interest;Investigational Therapies;Knowledge;Laboratories;Leadership;Link;Maryland;Measures;meetings;Mentors;method development;Methods;Modeling;Modernization;next generation;novel;Patient Care;Patients;Pharmaceutical Preparations;Pharmacodynamics;Pharmacogenomics;pharmacokinetics and pharmacodynamics;Pharmacology;pharmacometrics;Plasma;post-market;pre-clinical;preclinical study;Procedures;Regimen;Reporting;Research;Research Design;Research Personnel;sample collection;Sampling;Scientist;Series;Services;Source;Specimen Handling;Spottings;Structure of parenchyma of lung;synergism;Talents;Therapeutic;therapeutic development;Therapeutic Research;Training;training opportunity;translational study;Treatment outcome;Tuberculosis;tuberculosis drugs;tuberculosis treatment;Universities;Urine;Validation;Work;Writing

PROJECT_TITLE: Pharmacology and Pharmacometrics Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: AMHERST

ORG_DEPT: PHYSIOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: Project Narrative This study is to test the hypothesis that targeting histone demethylase LSD1 to adjust gene expression and ameliorate synaptic defects is a novel treatment strategy for autism. Both Shank3-deficient mouse models of autism and human neurons differentiated from stem cells of autism patient with Shank3 haploinsufficiency will be used to test this hypothesis. This study will provide great promise for the discovery of novel pharmacological agents to treat social deficits and repetitive behaviors associated with autism.

PI_NAMEs: FENG, JIAN ;YAN, ZHEN  (contact)

PROGRAM_OFFICER_NAME: DOSS, ARGENIA LANISHA NECOLE

PROJECT_TERMS: Address;Animal Model;ASD patient;autism spectrum disorder;autism symptoms;autistic;Autopsy;Behavioral;Biochemical;ChIP-seq;Chromatin;Corpus striatum structure;Defect;demethylation;DNA Sequence Alteration;drug discovery;Electrophysiology (science);Enzymes;Epigenetic Process;Etiology;Exhibits;Exons;Fibroblasts;Functional disorder;Gene Activation;Gene Expression;Gene Expression Alteration;gene repression;Genes;Genetic;Genetic study;Genetic Transcription;genome-wide;Genomics;Glutamates;Goals;Heterozygote;high risk;histone demethylase;histone methylation;histone methyltransferase;histone modification;Histones;Human;Human Genetics;human induced pluripotent stem cells;human stem cell-derived;human stem cells;Impairment;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;inhibitor;innovation;interdisciplinary approach;Intervention;KDM1A gene;knock-down;Large-Scale Sequencing;Length;Link;loss of function mutation;Lysine;Mediating;Methylation;model of autism spectrum disorder;Modeling;Molecular;Molecular Abnormality;mouse model;Mus;Neurodevelopmental Disorder;Neuronal Differentiation;neuronal excitability;Neurons;novel;novel therapeutic intervention;Pathogenicity;Patients;permissiveness;pharmacologic;Phelan-McDermid syndrome;Phenotype;Play;Prefrontal Cortex;Proteins;repetitive behavior;Research;response;Risk Factors;risk variant;Role;Scaffolding Protein;side effect;social deficits;Social Interaction;stem cell differentiation;stem cell technology;stem cells;Synapses;synaptic function;targeted agent;targeted treatment;Testing;Therapeutic;Therapeutic Effect;Tissues;transcription factor;Transcriptional Regulation;transcriptome sequencing;Translating;treatment strategy;Work

PROJECT_TITLE: Epigenetics-Based Autism Treatment with Animal Models and Human Stem Cells

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Data Science;Emerging Infectious Diseases;Infectious Diseases;Networking and Information Technology R&D (NITRD);Rare Diseases;Tuberculosis

PI_NAMEs: DOWDY, DAVID WESLEY (contact)

PROJECT_TERMS: Acceleration;Accountability;Address;Area;Bioinformatics;bioinformatics tool;Biometry;Biostatistics Core;career;Clinical;Clinical Data;Clinical Research;Cloud Computing;Collaborations;Communicable Diseases;Complex;Computational Technique;Computer Models;Computing Methodologies;computing resources;Data;Data Science;Data Set;Development;Disease;dynamic system;Educational workshop;Engineering;Ensure;Epidemic;Epidemiology;epidemiology study;experience;Faculty;FAIR principles;Fostering;genome-wide;Genomics;Goals;Granuloma;Health;Healthcare;Heterogeneity;high dimensionality;High Performance Computing;human pathogen;Human Subject Research;Individual;Infectious Diseases Research;innovation;insight;Institution;Interdisciplinary Study;interest;Knowledge;Learning;Macrophage;mathematical model;Medical;Medicine;meetings;Mentors;Modeling;Modernization;Mycobacterium tuberculosis;next generation;Organization administrative structures;Performance;Population;Predisposition;Process;Productivity;Proteomics;recruit;Research;Research Design;Research Personnel;Research Project Grants;Resources;Series;Services;success;synergism;technology development;Training;training opportunity;transmission process;Tuberculosis;Universities;Vision;Waxes;Writing


PI_NAMEs: SHAH, MAUNANK  (contact)

PROJECT_TERMS: Accountability;Address;Adherence;AIDS clinical trial group;Award;Baltimore;Belief;Bioethics;Biological Specimen Banks;Brazil;career;Caring;case finding;Categories;Cities;Clinic;Clinical;clinical care;clinical implementation;Clinical Investigator;Clinical Research;clinical research site;Clinical Sciences;Clinical Services;Clinical Trials;co-infection;cohort;Collaborations;Communication;Communities;comorbidity;cost;Country;Coupled;data resource;Databases;Detection;Development;Diagnostic;Disease;Ensure;Environment;epidemiology study;Faculty;FAIR principles;Feedback;Fostering;Foundations;Funding;Generations;global health;Goals;Grant;Health;HIV;Human Resources;Human Subject Research;implementation intervention;improved;Incidence;Incubated;India;Infection;Infrastructure;innovation;Institution;Institutional Review Boards;interdisciplinary collaboration;Interdisciplinary Study;International;International Maternal Pediatric Adolescent AIDS Clinical Trials;Investigation;K-Series Research Career Programs;Knowledge;Link;material transfer agreement;Measures;meetings;Mentors;Mentorship;Methodology;Modeling;Morbidity - disease rate;mortality;multidisciplinary;Natural History;Newsletter;next generation;novel;Pathogenesis;patient population;Patients;Policies;Population;Prevention;Preventive therapy;Process;Public Health;public health research;Recovery;Reporting;Research;Research Activity;Research Infrastructure;Research Methodology;Research Personnel;Research Priority;Research Support;Resources;searchable database;Series;skills;South Africa;Specimen;Stream;Structure;Sum;supportive environment;symposium;synergism;Talents;Therapeutic;Training;Translating;Translational Research;transmission process;Tuberculosis;Uganda;United States National Institutes of Health;Universities;Update;web site;Work;Writing

PROJECT_TITLE: Clinical Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: IRVINE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Despite their protective role in infection, dysregulated expression of inflammatory genes can be deleterious to the host. Many patients suffering from the pandemic COVID-19 caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) display overt inflammation, leading to morbidity and mortality. This proposal aims to take an integrated approach to characterize the role of epigenetic factors controlling DNA topology (topoisomerases) in regulating inducible transcription in COVID-19 response, and determining if the anti-inflammatory effects previously observed for Topoisomerase inhibitors in vivo are therapeutic in animal models of COVID-19.

PI_NAMEs: MARAZZI, IVAN  (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 2019-nCoV;ACE2;Acute;adaptive immunity;Affect;Animal Model;Animals;Anti-Inflammatory Agents;Antigens;Antiinflammatory Effect;antimicrobial;arm;Bacterial Infections;Buffers;cell type;Cells;Cessation of life;Chemicals;chemokine;Chromatin;chromatin remodeling;Chronic;Clinical Trials;cost;COVID-19;COVID-19 pandemic;COVID-19 patient;COVID-19 treatment;Cytokeratin 18;cytokine;Cytokine Signaling;Dexamethasone;DNA;Drug usage;Epigenetic Process;Event;Failure;FDA approved;feasibility testing;fitness;Gene Activation;Gene Expression;gene induction;Generations;Genes;Genetic Transcription;Genome;Genomic approach;Glucocorticoids;Goals;Housekeeping Gene;Human;Immune;Immune response;In Vitro;in vivo;inducible gene expression;Infection;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Innate Immune Response;insight;Interleukin-1;Interleukin-6;Invaded;K-18 conjugate;Kinetics;Knowledge;Link;Mediating;Medicine;Molecular;Morbidity - disease rate;mortality;neutralizing antibody;novel therapeutics;Oncology;Organ;Organism;pathogen;Pathologic;Patients;Pharmaceutical Preparations;Pharmacotherapy;Pre-Clinical Model;Preclinical Testing;prevent;Process;programs;promoter;receptor;Recovery;Regulation;Reporting;Repression;response;RNA Polymerase II;Role;SARS-CoV-2 infection;secondary infection;severe COVID-19;side effect;Signal Induction;Signal Pathway;Signal Transduction;Specificity;standard of care;Symptoms;Testing;Therapeutic;Therapeutic Intervention;Therapeutic Uses;therapy development;Tissues;TNF gene;Topoisomerase;Topoisomerase Inhibitors;Topotecan;Transgenic Mice;Viral;Virus;Virus Diseases;virus host interaction

PROJECT_TITLE: Regulation of inflammatory gene expression during SARS2 infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-D(90)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE Understanding the relative abundance of beneficial, neutral, and deleterious mutations in different variant categories (e.g., genic vs. intergenic) provides useful guidance and resources for biomedical researchers to prioritize disease-causing mutations and strategize their efforts. To date, however, little effort has been made to study the full spectrum of fitness effects of new structural variants – an important but largely underappreciated genomic variation. The work proposed here seeks to leverage long-read sequencing technologies and develop novel machine-learning approaches to quantify the fitness effects of new mutation, with a focus on structural variants, and subsequently delineate the relative importance among different types of mutations in genetic diseases.

PI_NAMEs: HSIEH, PINGHSUN  (contact)

PROGRAM_OFFICER_NAME: ARGUELLO, ALEXANDER

PROJECT_TERMS: Advisory Committees;Affect;Area;autism spectrum disorder;Award;Base Pairing;Benchmarking;biological systems;biomedical resource;career;Categories;cohort;Communities;Complex;Copy Number Polymorphism;Data;Demography;Development;Diploidy;Disease;disease-causing mutation;DNA;DNA Sequence;Etiology;Evolution;expectation;fitness;Frequencies;Future;Genes;Genetic;Genetic Diseases;Genetic Drift;Genetic Models;Genetic Polymorphism;genetic variant;Genome;genome sciences;genome sequencing;genome wide association study;genomic locus;genomic variation;Genomics;Genotype;Goals;high throughput technology;Human;Human Genome;human population genetics;improved;Individual;Knowledge;Laboratories;Learning Skill;Machine Learning;machine learning method;Medical;Medical Genetics;Mentors;Methods;model organism;Modeling;Modernization;Mutation;Natural Selections;Nature;nonhuman primate;novel;Organism;Outcome;Parents;Pathogenicity;Pathway interactions;Phase;Phylogenetic Analysis;Population;Population Genetics;pressure;Primates;Public Health;Quantitative Trait Loci;Recurrence;Relaxation;Research;Research Personnel;Resource Development;Resources;Sample Size;Sampling;Scientist;Shapes;Signal Transduction;simulation;Single Nucleotide Polymorphism;skills;Supervision;Technology;Testing;Training;Training Programs;trait;Uncertainty;United States National Institutes of Health;Universities;Variant;Washington;Work

PROJECT_TITLE: The fitness effects of de novo structural variants

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: SAINT LOUIS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Our aging population is expected to develop increased incidences of neurodegenerative disease and dementia, but the molecular mechanisms that underlie these complex processes remain poorly understood. This proposal aims to understand how neuronal activity-dependent gene expression and DNA damage repair can regulate brain aging by leveraging a newly identified neuronal-specific protein complex, NPAS4:NuA4. These experiments will lay critical groundwork for designing targeted strategies to slow or reverse decline in the neuronal subtypes most susceptible to age-dependent diseases.

PI_NAMEs: POLLINA, ELIZABETH A (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Acceleration;Acetyltransferase;Action Potentials;Acute;Adult;Affect;Age;age related;age related changes;age-related disease;Aging;aging brain;aging population;Atrophic;Binding;Bioinformatics;Brain;Calcium;Calcium Signaling;Cell membrane;Cell Physiology;cell type;Cellular biology;Cellular Stress;Chromatin;cognitive training;Communication;Complex;Cues;Data;Data Set;Defect;design;Deterioration;Diagnosis;DNA Damage;DNA Double Strand Break;DNA Repair;Double Strand Break Repair;Elements;Enhancers;Epidemiology;excitatory neuron;experimental study;Functional disorder;Gamma-H2AX;Gene Activation;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene induction;Gene Targeting;Genes;Genetic Transcription;Genome Stability;genomic locus;Genomics;Goals;healthy aging;Hippocampus;HTATIP gene;Human;Impaired cognition;Impairment;in vivo;Incidence;Individual;inhibitory neuron;Inhibitory Synapse;Invertebrates;juvenile animal;Knockout Mice;Knowledge;Learning;life span;Link;Maintenance;Maps;Mediating;Mediator;Memory;Molecular;Mus;Mutation;Nervous System;neural circuit;Neurobiology;neurodegenerative dementia;Neurodegenerative Disorders;neuronal circuitry;Neurons;novel;NPAS4 gene;Phase;Population;Predisposition;premature;preservation;Process;programs;promoter;Property;protein complex;recruit;Regulation;Regulator Genes;Repair Complex;repaired;Reporting;response;Risk Factors;Role;sensory stimulus;Signal Transduction;Site;skills;Stimulus;Synapses;Testing;Tissues;Training;Transcription Coactivator;transcription factor;Transcriptional Regulation;Work

PROJECT_TITLE: Neuronal Circuit Maintenance in Healthy Aging


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: HOUSTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative The purpose of this project is to contribute to increasing diversity, inclusivity, and belonging for those underrepresented in the biomedical workforce that is known to increase productivity of teams in the biomedical sciences. Specifically, this proposal seeks funding for eight PhD trainees who will engage in activities to strengthen their academic skills and confidence, promote their career exploration across biomedical fields, and establish a community of belonging. The proposed activities will improve the overall environment of the graduate school and help our students excel as researchers to propel them to careers of their choice in the biomedical scientific community.

PI_NAMEs: COLE, FRANCESCA ;SHADDING, CHERILYNN R (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TITLE: The Academy at MD Anderson UTHealth Houston Graduate School  - Maximizing Opportunities for Training, Development, and Community

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Gene Therapy;Genetics;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: JOHNSON CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: EAST TENNESSEE STATE UNIVERSITY

ORG_STATE: TN

PHR: NARRATIVE Patients with HBV infection are subject to prolonged (often lifelong) treatment due to the lack of curative therapeutics. Thus, multimodal, robust therapeutic strategies are urgently needed to eliminate HBV cccDNA, which sustains viral replication and is refractory to the current antiviral regimens. Recently, we have designed and selected specific and potent gRNA/Cas9 HBV gene-editing drugs using HBV cellular models. We have also developed an exosome-based drug delivery system packaged with these synthetic gRNA/Cas9 HBV gene-editing drugs to specifically target human hepatocytes. In this proposal, we will evaluate the antiviral efficacy and any potential off-target effects of a novel gRNA/Cas9/Cas12/Cas13-based gene-editing regimen targeting HBV DNA and RNA, both in vitro and in vivo. The objective of this project is to lay the foundation for future clinical studies, to achieve our long-term goal of curing chronic HBV infection. If successful, this novel drug design and delivery platform may be utilized to combat existing and emerging viral diseases. It is thus clinically significant, timely, and relevant to public health.

PI_NAMEs: YAO, ZHI Q. (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: analog;Animal Model;Animals;anti-viral efficacy;Binding;Biodistribution;Biogenesis;biomaterial compatibility;Cell model;Cells;Chronic Hepatitis B;chronic infection;Circular DNA;Clinical;Clinical Research;clinically significant;Clustered Regularly Interspaced Short Palindromic Repeats;combat;comparison control;CRISPR therapeutics;CRISPR/Cas technology;curative treatments;cytotoxic;cytotoxicity;Deoxyribonuclease I;design;detection method;DNA;Drug Delivery Systems;Drug Design;Drug Targeting;Drug usage;engineered exosomes;Engineering;Exhibits;exosome;Formulation;Foundations;Future;gene therapy;Genes;genetic technology;Goals;Guide RNA;Half-Life;Hepatitis B Infection;Hepatitis B Surface Antigens;Hepatitis B Virus;Hepatocyte;HepG2;Human;humanized mouse;immunogenicity;In Vitro;in vivo;innovation;Insertional Mutagenesis;intravenous administration;Kinetics;Life Cycle Stages;Liver;Mediating;Modality;multimodality;Mus;Mutation;Na(+)-taurocholate-cotransporting peptide;novel;novel therapeutics;nucleofection;Patients;Peptides;Pharmaceutical Preparations;Phase;Production;Public Health;Readiness;Refractory;Regimen;Research;Resistance;Ribonucleoproteins;Risk;RNA;RNA Editing;Safety;Series;side effect;Site;Specificity;Surface;System;Technology;Testing;Therapeutic;therapeutic candidate;Tissues;trafficking;Transcript;translational study;United States;Viral;viral DNA;Viral reservoir;viral RNA;Viral Vector;Virus Diseases;Virus Receptors;Virus Replication

PROJECT_TITLE: Engineering exosomes for new gRNA/Cas therapeutics to  eliminate HBV infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 SAS-M (S2)]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Dissemination and Implementation Research;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric

ORG_CITY: ROCHESTER

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE Acute kidney injury (AKI) occurs frequently in critically ill children and existing decision support tools designed to improve patient care quality and safety have shown limited effectiveness while simultaneously increasing provider alert burden fatigue. This proposal will develop an integrated pipeline to support validated, shareable, usable decision support tools for subsequent clinical trials. Its success will launch a research program focused on improving the care and outcomes of critically ill children with acute kidney injury while reducing provider fatigue.

PI_NAMEs: DZIORNY, ADAM C. (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;Adoption;Algorithms;Architecture;Artificial Intelligence;Attention;Biological Markers;Calibration;career;Caring;Child;Childhood;Clinical;clinical decision support;Clinical Decision Support Systems;Clinical effectiveness;Clinical Trials;Clinical Trials Design;cloud based;Cognitive;Complication;Creatinine;Critical Care;Critically ill children;Data;data de-identification;Data Set;data streams;Decision Support Systems;Derivation procedure;design;Development;Discipline of Nursing;Discrimination;Disease;Early identification;Effectiveness;efficacy testing;Electronic Health Record;Ensure;Evaluation;Fast Healthcare Interoperability Resources;Fatigue;Foundations;Frustration;Future;Goals;Health Status;high risk;implementation evaluation;implementation science;implementation strategy;improved;informatics tool;innovation;Institution;interoperability;K-Series Research Career Programs;Knowledge;Life;Liquid substance;Machine Learning;machine learning method;machine learning model;Measures;Mentors;Methodology;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;multidisciplinary;nephrotoxicity;novel;novel strategies;Outcome;Output;Patient Care;patient safety;Patient-Focused Outcomes;Patients;Performance;Pharmaceutical Preparations;Phenotype;Physicians;Physiological;Physiology;point of care;Positioning Attribute;predictive modeling;predictive tools;Predictive Value;preference;process improvement;Process Measure;programs;prospective;Provider;Quality of Care;Recommendation;Renal Replacement Therapy;Research;Risk;risk prediction;risk prediction model;Safety;Serum;success;support tools;System;Technology;Testing;tool;Training;Translating;Translations;Urine;usability;user centered design;Validation;Work

PROJECT_TITLE: Pediatric Acute Kidney Injury Prediction Using Generalized, Sharable, Usable Decision Support

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Hematology;Orphan Drug;Pediatric;Rare Diseases;Sickle Cell Disease

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: Project Narrative Abnormalities in red cell production and/or function can lead to life-threatening conditions. The program proposed in this application focuses on two red cell disorders, Diamond Blackfan anemia (DBA) and sickle cell disease (SCD) filling important gaps in our understanding of the molecular mechanisms leading to the etiology of DBA and the role of the bone marrow niche in both DBA and SCD. Completion of the program will lead to the development of novel therapies based on a better understanding of the pathophysiology of these disorders.

PI_NAMEs: BLANC, LIONEL  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Adult;Affect;Anemia due to Chronic Disorder;Biogenesis;Biology;Birth;Bone Marrow;bone marrow failure syndrome;Cell Cycle;Defect;Development;Diamond-Blackfan anemia;Disease;Economic Burden;Erythrocytes;Erythroid;Erythropoiesis;Etiology;fetal;Fetal Hemoglobin;Functional disorder;Heart Diseases;Hematological Disease;immune modulating agents;Inflammation;Inflammatory;Island;Length;Life;Modeling;Molecular;Morbidity - disease rate;mortality;Nature;neonatal human;novel therapeutics;Persons;Process;Production;Productivity;programs;Regulation;Research;Ribosomal Proteins;Ribosomes;Role;Sickle Cell Anemia;Steroid Resistance;Testing;Work

PROJECT_TITLE: Cellular and Molecular Control of Normal and Disordered Erythropoiesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-L (O2)]


ORG_CITY: MADISON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Viruses that jump from animals to humans pose a significant threat to the health and wellbeing of humankind. To defend against the emergence of future viruses in humans, we will focus on an understudied family of animal viruses that are distantly related to coronaviruses – the arteriviruses – and identify molecular determinants of cross-species infection. Understanding the biology of arteriviruses in greater detail will improve our risk assessment of these viruses and will provide a foundation of tools, knowledge, and systems that could be used to combat a novel arterivirus outbreak in humans.

PI_NAMEs: BAILEY, ADAM LEE (contact);WARREN, CODY JAY

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: 2019-nCoV;Air;Animals;Arterivirus;Arterivirus Infections;Binding;Biological;Biological Assay;biological systems;Biology;Biomedical Research;Bypass;Cell surface;Cells;Cellular Membrane;Chromosome Mapping;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;combat;Communities;Complex;Coronavirus;COVID-19;COVID-19 pandemic;Development;Diagnostic;Disease;Disease Outbreaks;Distant;Domestic Animals;Endosomes;Equus caballus;Event;experimental study;Family;Family suidae;Fc Receptor;Food Supply;Foundations;Future;Gene Proteins;Genes;Genetic;Genetic Variation;genome-wide;Health;Human;improved;Infection;Integration Host Factors;Intervention;Investments;Knock-out;Knowledge;Life;Life Cycle Stages;Mammals;Maps;Mediating;medical countermeasure;Molecular;Monkey Hemorrhagic Disease Virus;Monkeys;Mus;Mutation;neglect;neonatal Fc receptor;nonhuman primate;novel;novel virus;Orthologous Gene;overexpression;pandemic preparedness;particle;Pathogenesis;permissiveness;Personal Satisfaction;Positioning Attribute;Predisposition;Primates;programs;Property;receptor;receptor function;Research;Resources;Retinal blind spot;Risk;Risk Assessment;RNA Viruses;Rodent;Role;Series;skills;System;technology platform;Testing;Therapeutic;Thinness;tool;Vaccines;Variant;Viral;Virion;Virus;Virus Diseases;Virus Receptors;Wild Animals;Zoonoses

PROJECT_TITLE: Arterivirus receptors: rules of engagement for cross-species infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-U (02)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Endocrine Disruptors;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Per- and polyfluoroalkyl Substances (PFAS) are chemicals that are widely used in industrial and commercial activities, and of growing concern due to persistence in the body and environment and emerging evidence of carcinogenic effects. Higher PFAS exposure may increase risk of prostate cancer (CaP), the most commonly diagnosed non-cutaneous cancer and second leading cause of cancer-related death in US men, but few large, population-based studies have tested this hypothesis in a racially and socioeconomically diverse population. This study builds on prior work to examine environmental causes of racial disparities in CaP using registry- based cohort data to link a spatiotemporal model of drinking water exposure to PFAS to estimate impacts on aggressive CaP incidence, and will investigate sources of PFAS exposure and potential influences on biochemical recurrence of CaP in a pilot study of survivors.

PI_NAMEs: IYER, HARI S (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: Accounting;Acids;Address;advanced prostate cancer;Aftercare;Age;American;Animal Model;Award;bioaccumulation;Biochemical;Biological;black men;Black race;Blood specimen;Businesses;Cancer Biology;cancer diagnosis;cancer epidemiology;Cancer Etiology;cancer health disparity;Cancer Institute of New Jersey;carcinogenicity;Carcinogens;career;Censuses;Cessation of life;Chemical Exposure;Chemical Models;Chemicals;Classification;cohort;Collection;Communities;contaminated drinking water;Data;Data Collection;Data Set;Death Rate;Development;Diagnosis;dietary;Dietary Practices;Disparity;Distant;drinking;drinking water;Early Diagnosis;Endocrine disruption;Endocrine Disruptors;Environment;environmental chemical;Environmental Epidemiology;Environmental Pollutants;Environmental Protection;Epigenetic Process;Ethnic Origin;experience;Exposure to;Family history of;Fertility;General Population;Genetic;Geography;Goals;Gonadal Steroid Hormones;Health;Health Services Accessibility;high risk;Hormones;Human;hydrology;Immunosuppression;Incidence;Industrialization;Knowledge;Linear Regressions;Link;Lipids;Location;Logistic Regressions;low socioeconomic status;male;Malignant neoplasm of prostate;Malignant Neoplasms;Masks;Measures;men;Mentors;Metabolic syndrome;Modeling;modifiable risk;Molecular;mortality;multidisciplinary;Neighborhoods;neoplasm registry;New Jersey;Occupational;Odds Ratio;Operative Surgical Procedures;Organ;Outcome;Participant;Pathway interactions;Patients;Pattern;perfluorooctane sulfonate;perfluorooctanoic acid;Pilot Projects;Poison;Pollution;Poly-fluoroalkyl substances;Population;Population Heterogeneity;Population Study;Prevention;Primary Prevention;Principal Component Analysis;Privatization;prostate cancer prevention;prostate cancer progression;prostate cancer risk;prostate cancer survivors;Prostate Cancer therapy;prostate carcinogenesis;Public Health;Publications;Questionnaires;Race;racial discrimination;racial disparity;racial diversity;Radiation therapy;Recording of previous events;recruit;Recurrence;Registries;Reporting;Reproduction;Research;Research Personnel;residential segregation;Risk;Risk Estimate;Risk Factors;Scientist;segregation;Serum;Signal Transduction;skills;sociodemographic group;sociodemographics;Socioeconomic Status;socioeconomics;Soil;Source;spatiotemporal;Survivors;symposium;System;Testing;Tissues;Training;Training Programs;Tumor Biology;Water;Water consumption;water sampling;Water Supply;water testing;Work

PROJECT_TITLE: Exposure to Per- and Polyfluoroalkyl Substances and Prostate Cancer: Opportunities for Prevention and Early Detection

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 BWD-D (KS)]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Infectious Diseases;Microbiome;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: DENTISTRY

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Project Narrative Oral cancer is a deadly and debilitating disease that continues to have poor prognosis despite advances in treatment. There is a growing body of evidence implicating the fungus Candida albicans and the bacterium Fusobacterium nucleatum in the development of oral cancer; however, whether the two species interact to promote carcinogenesis is not known. In this application, we employ laboratory and animal experiments to investigate such interkingdom interaction in oral cancer.

PI_NAMEs: AL-HEBSHI, NEZAR  (contact);MORAN, GARY P.

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: 16S ribosomal RNA sequencing;4-Nitroquinoline-1-oxide;Accounting;Address;Animal Experiments;Animal Model;Area;Bacteria;Biochemical;Biological Assay;Cancer cell line;Candida albicans;carcinogenesis;carcinogenicity;Carcinogens;Carcinoma;Carcinoma in Situ;Cell Line;Cell Proliferation;Cells;Cessation of life;Chemicals;Chronic;Clinical;co-infection;Coculture Techniques;Data;Development;Disease;dysbiosis;Dysplasia;Epithelial Cells;epithelial to mesenchymal transition;experimental study;Financial Hardship;Flow Cytometry;Fluorescent in Situ Hybridization;Foundations;fungus;Fusobacterium nucleatum;Genes;Genetic Transcription;Goals;Health;Histopathologic Grade;Histopathology;Hyperkeratosis;Immune response;Immunohistochemistry;In Vitro;in vivo;Inflammation;INHBA gene;innovation;insight;interest;Invaded;keratinocyte;knock-down;laboratory experiment;Malignant - descriptor;malignant mouth neoplasm;Malignant Neoplasms;Mediating;Membrane Proteins;metatranscriptome;metatranscriptomics;microbial;microbiome;microorganism interaction;migration;Molecular;mouse model;mouth squamous cell carcinoma;Mus;mutant;neoplastic;novel;Oncogenes;Oncogenic;Oral;oral bacteria;oral carcinogenesis;oral cavity epithelium;oral lesion;Oral Leukoplakia;oral microbiome;Pathway interactions;Pilot Projects;primary outcome;Production;Prognosis;programmed cell death ligand 1;Proliferating;Property;receptor;Research;response;Role;Sampling;synergism;Technology;Testing;Time;Tissues;transcriptomics;Transforming Growth Factor beta;Tumor Promotion;Tumor Tissue;Up-Regulation;Xenograft Model

PROJECT_TITLE: The role of Fusobacterium nucleatum and Candida albicans interkingdom interactions in promoting OSCC

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Immunotherapy;Kidney Disease;Rare Diseases

PHR: Project Narrative The proposed research is relevant to public health because it will provide strategies for increasing cancer patients’ survival rates. This work will develop tools for improving the application of current immunotherapy for treating kidney cancers. Thus, the proposed research is relevant to NIH’s mission in reducing illness and disability.

PI_NAMEs: CHIOU, SHIN-HENG  (contact);HINRICHS, CHRISTIAN

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Affinity;American;anti-cancer;Antibodies;Antigen Targeting;antigen-specific T cells;Antigens;B lymphoid malignancy;Binding;Biological Assay;cancer cell;Cancer Institute of New Jersey;Cancer Patient;cancer therapy;cancer type;CAR T cell therapy;CD19 gene;Cell Line;Cell surface;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Clear cell renal cell carcinoma;clinical application;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Complementary DNA;cytotoxic;Data;Dendritic Cells;disability;engineered T cells;Engineering;Epitopes;experience;experimental study;Future;Genes;Germ Lines;Good Manufacturing Process;HLA Antigens;Immune response;Immunotherapy;improved;In Vitro;in vivo;Interferon Type II;Knock-out;Laboratories;Libraries;Malignant Neoplasms;Mediating;Mission;Modeling;Monitor;Multiple Myeloma;Mus;neoplastic cell;novel;Outcome;Patients;Peptides;Play;preclinical study;Public Health;receptor binding;Renal Carcinoma;Renal Cell Carcinoma;Research;response;Role;Sampling;Specificity;Survival Rate;T cell receptor repertoire sequencing;T cell therapy;T-Cell Activation;T-Cell Receptor;T-Cell Receptor Therapy;T-Lymphocyte;targeted treatment;Therapy trial;tool;tumor;Tumor Antigens;Tumor Tissue;tumor xenograft;Tumor-Infiltrating Lymphocytes;United States Food and Drug Administration;United States National Institutes of Health;Work

PROJECT_TITLE: Developing TCR-T cell therapy in renal cell carcinoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-1 (O2)]


NIH_SPENDING_CATS: Clinical Research;Lung;Machine Learning and Artificial Intelligence;Microbiome;Organ Transplantation;Transplantation

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The leading cause of poor outcomes for lung transplant recipients is chronic rejection, but we lack prediction models both for 1) the development of chronic rejection and 2) survival after chronic rejection. Chronic rejection has been associated with changes in the lung microbiome (i.e., the community of bacteria in the lungs), the recipient's immune response, and lung scarring that originates from mesenchymal cells that reside in the transplanted lung. This project will integrate clinical data with biological signals from the lung microbiome, immune response, and mesenchymal cell activation to: 1) Develop prediction models for the development of chronic rejection in healthy lung transplant recipients, and 2) Develop prediction models for survival at the time chronic rejection is diagnosed.

PI_NAMEs: COMBS, MICHAEL PETER (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Advisory Committees;Allografting;Azithromycin;Bacteria;Biological;Biological Factors;Bronchiolitis Obliterans;Bronchoalveolar Lavage;Bronchoalveolar Lavage Fluid;Bronchoscopy;career development;Caring;Cause of Death;Cells;Cellular biology;Cessation of life;Chronic;Clinical;Clinical Data;clinical heterogeneity;clinical phenotype;Clinical Research;clinical risk;Clinical stratification;Clinical Trials;cohort;Comb animal structure;Communities;Complex;Computational Biology;Critical Care;Data;design;Development;Development Plans;Diagnosis;Dimensions;Disease;Doctor of Philosophy;effective therapy;experience;Failure;fibrotic lung;Functional disorder;Goals;Immune response;Immune signaling;Immunology;improved;improved outcome;individualized medicine;insight;Lung;lung allograft;lung microbiome;lung microbiota;Lung Transplantation;Machine Learning;machine learning model;Measures;Mentors;Mentorship;Mesenchymal;Michigan;microbiome;Modeling;Morbidity - disease rate;mortality;Newly Diagnosed;novel;Organ Transplantation;Outcome;Pathogenesis;patient oriented;Patients;personalized care;Phenotype;Physicians;Physiological;Positioning Attribute;post-transplant;predictive modeling;predictive tools;Prognosis;prognostic significance;prognostication;prospective;Publishing;pulmonary function;radiological imaging;Research;Research Personnel;Research Project Grants;retransplantation;Risk;Risk Factors;risk prediction;risk prediction model;Role;Scientist;Signal Transduction;Solid;Statistical Data Interpretation;Statistical Models;Syndrome;Testing;Time;Training;translational study;Transplant Recipients;Transplantation;treatment response;Universities;Variant;Work

PROJECT_TITLE: Advancing our Understanding of the Development, Phenotypes, and Progression of Chronic Rejection after Lung Transplantation

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (OA)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) and related dementia syndromes (ADRD) represent an enormous challenge for patients, families, caregivers, and health care systems. Rare cases of autosomal dominant AD (ADAD) offer a unique window into the biologic changes that cause AD and a compelling opportunity to intervene to stop the development of early-onset AD. In My K01 project, I will characterize how the hundreds of different, disease- causing genetic variants in Presenilin-1 (the most common cause of ADAD) are similar and different in their biologic effects, and thereby better understand AD biology, inform drug development, and improve chances for success in ADAD clinical trials.

PI_NAMEs: SCHULTZ, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Abeta synthesis;Affect;Age;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-42;Amyloid beta-Protein;Amyloid beta-Protein Precursor;amyloid precursor protein processing;autosomal dominant Alzheimer's disease;autosome;Biological;Biological Assay;Biological Markers;Biological Models;Biology;biomarker development;career;Caregivers;Catalytic Domain;Cell model;Cells;Characteristics;Classification;Clinical;clinical heterogeneity;Clinical Trials;Clinical Trials Design;Codon Nucleotides;Cognition;Cognitive;Communities;Complement;Complex;Cytoplasm;Data;Data Set;design;Development;Disease;Disease Progression;drug development;Early Onset Alzheimer Disease;Equilibrium;Family;Future;gamma secretase;genetic variant;Grouping;Healthcare Systems;Heterogeneity;Hippocampus;Immunoassay;improved;In Vitro;Inherited;innovation;International;Kinetics;Laboratories;Leadership;Location;Measures;medical schools;Membrane;Mentors;Mentorship;Methods;Modeling;multidisciplinary;mutant;Mutation;Nerve Degeneration;novel;novel therapeutics;Observational Study;Outcome;Pathogenicity;Pathologic;Patients;Phenotype;Population;Positron-Emission Tomography;presenilin-1;Production;progression marker;Proteins;rate of change;Research;response;secretase;skills;Statistical Data Interpretation;Statistical Methods;Stratification;success;Sum;Symptoms;Syndrome;Tertiary Protein Structure;Therapeutic;Training;Translational Research;translational research program;translational scientist;Translational trial;treatment effect;Variant;Work

PROJECT_TITLE: Identifying variations in gamma-secretase function that are critical determinants of clinical and biomarker progression of Autosomal Dominant Alzheimer's disease: From mechanism to clinical trials

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: SEATTLE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Here we will examine the neuronal mechanisms of Neuropeptide S (NPS), a neuropeptide shown to increase drug-seeking behavior as well as inhibit stress-induced behaviors. The orbitofrontal cortex (OFC) is a brain region linked to natural reward and drug-seeking behavior, which I found receives input from hindbrain NPS neurons. This proposal seeks to thoroughly determine how NPS transmission in the OFC and downstream targets is recruited during repeat exposure to high value rewards, ultimately identifying potentially novel treatment targets for treating opiate use disorder.

PI_NAMEs: GIRVEN, KASEY SHEA (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Affect;allostatic load;Amygdaloid structure;Anatomy;antagonist;Anxiety;Anxiety Disorders;anxiety-like behavior;Arousal;Automobile Driving;Behavior;Behavioral;Brain;Brain region;Calcium;career;career development;cell type;Cells;cohort;comorbidity;conditioned fear;Conditioned Stimulus;Consumption;Coupled;Cre driver;Cues;Decision Making;Development;drug misuse;drug reward;drug seeking behavior;Drug Targeting;Exposure to;Fentanyl;fentanyl seeking;fentanyl self-administration;Fiber;flexibility;Future;Goals;Grant;Head;hindbrain;Hypothalamic structure;Image;Impairment;in vivo calcium imaging;Individual;Infusion procedures;Institution;Internal Ribosome Entry Site;Investigation;Knowledge;Label;Lateral;Light;Link;locus ceruleus structure;Maps;Measures;Mediating;Molecular;Mus;Neurobiology;Neurons;Neuropeptides;neuroregulation;Neurosciences;novel;Operant Conditioning;opioid use disorder;optogenetics;Oral;parabrachial nucleus;Peptides;Photometry;Population;Psychological reinforcement;receptor;recruit;Regulation;Research Personnel;Research Project Summaries;response;reward processing;Rewards;Role;Series;Signal Transduction;Site;skill acquisition;Source;Stimulus;Stress;substance misuse;Substance Use Disorder;Sucrose;System;Techniques;Testing;Time;Training;transmission process;two photon microscopy;Viral;Work

PROJECT_TITLE: Decoding Neuropeptide S Modulation of OFC-mediated Reward Seeking

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 MXS-T (O2)]


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Clinical Research;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Silence ALS is a partnership between Columbia University and the n-Lorem Foundation to develop antisense oligonucleotide (ASO) medicines for patients with ultra-rare, genetic forms of ALS through a non-profit, precision medicine platform. With support from the URGenT Network, Silence ALS will develop nine ASOs targeting a variety of ultra-rare ALS gene mutations through investigational new drug (IND) clearance. The completion of the proposed work will establish Silence ALS as a model for therapeutic development in ultra-rare disease.

PI_NAMEs: SHNEIDER, NEIL ALAN (contact)

PROGRAM_OFFICER_NAME: BOSHOFF, CHRIS

PROJECT_TERMS: Acceleration;Affect;Alleles;ALS patients;Amendment;American;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Award;C9ORF72;Cell model;clinic ready;Clinical;Clinical assessments;clinical development;clinical infrastructure;Clinical Protocols;Clinical Research;clinical trial protocol;cohort;Communities;Data;de novo mutation;design;Development;Disease;disease-causing mutation;DNA Sequence Alteration;Dominant-Negative Mutation;Dose;drug clearance;Engineering;Enrollment;Ensure;experience;Family;Fibroblasts;first-in-human;Foundations;Frontotemporal Dementia;Future;gain of function;gene function;Gene Mutation;Gene Silencing;gene therapy;Generations;Genes;Genetic;genetic testing;Goals;Guidelines;Haplotypes;Health Services Accessibility;In Vitro;in vivo;in vivo evaluation;Individual;individualized medicine;induced pluripotent stem cell;Industrialization;Industry;Institutional Review Boards;Investigational Drugs;Knowledge;lead candidate;Medicine;meetings;Messenger RNA;Mission;Modality;Modeling;Molecular Target;mutant;Mutate;Mutation;National Institute of Neurological Disorders and Stroke;Neurodegenerative Disorders;Pathogenicity;patient population;Patient Recruitments;Patients;Phase;precision medicine;Precision Medicine Initiative;preclinical study;preservation;programs;protein TDP-43;protocol development;Protocols documentation;Rare Diseases;rare variant;Readiness;Regulatory Pathway;research clinical testing;Research Infrastructure;Research Personnel;Resources;Risk;Savings;screening;Series;success;superoxide dismutase 1;Technology;Therapeutic;therapeutic development;therapeutic gene;therapy development;Time;Toxic effect;Transcript;Translational Research;treatment planning;Treatment Protocols;Universities;Variant;Work

PROJECT_TITLE: Silence ALS: A Platform for the Discovery and Development of Antisense Therapeutics for Patients with Ultra-Rare Forms of ALS

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-M (15)]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: WORCESTER

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE The overarching goal of this proposal is to gain a deeper understanding of OPC phagocytosis in both health and disease and determine how phagocytosis alters their differentiation capacity. These results will have implications for neurodegenerative disease as lack of OPC differentiation is observed in multiple neurodegenerative states. This data will lay critical groundwork for future investigation into the diverse functions of OPCs in disease and will provide novel insight into new mechanisms that may alter OPC differentiation.

PI_NAMEs: BEITER, REBECCA MARIE (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Adult;Affect;Animal Model;Automobile Driving;Biological Assay;Biology;Brain;brain cell;Brain Diseases;catalyst;comparative;Complement;Complement 3a;Coupled;Data;Deposition;Development;Disease;experimental study;Failure;Functional disorder;Future;Gene Expression;genetic approach;Goals;graduate school;Health;imaging genetics;In Vitro;in vivo;in vivo Model;inhibitor;insight;Investigation;Kinetics;Learning;Life;live cell imaging;Mediating;Microglia;Molecular Genetics;mouse model;Multiple Sclerosis;Myelin;Nature;Nerve Degeneration;Nervous System Disorder;neural;Neurodegenerative Disorders;Neuroglia;neuroinflammation;novel;oligodendrocyte progenitor;Oligodendroglia;Pathology;Pathway interactions;Phagocytes;Phagocytosis;Phenotype;Play;Positioning Attribute;Postdoctoral Fellow;Process;progenitor;receptor;remyelination;repaired;Reporting;Research Personnel;Role;Shapes;stem cell biology;stem cell differentiation;stem cell function;stem cells;Synapses;targeted treatment;Techniques;Therapeutic Intervention;Therapeutic Uses;Thinking;Time;Training;transcriptome;transcriptome sequencing;Work

PROJECT_TITLE: A Comparative Analysis of OPC and Microglia Phagocytosis and its Relevance to Neurodegenerative Disease

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-4 Study Section [NST-4]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Data Science;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Patient Safety;Prevention

ORG_CITY: STANFORD

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE: Currently, no methods exist to prevent the onset of retinal tears and subsequent rhegmatogenous retinal detachments except to caution patients of new floaters, flashes of light and curtains in their vision. In spite of these warnings, patients may present late after the onset of symptoms resulting in poorer visual outcomes even after detachment repair. In this proposal, Dr. Cassie Ludwig aims to determine whether the use of clinical structured and unstructured variables in the electronic health record in addition to ultra-widefield color fundus photography can aid in improving prediction of risk of tears and detachments in myopic and non-myopic patients and thereby allow physicians to consider early prophylactic treatments.

PI_NAMEs: LUDWIG, CHASE  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Affect;Algorithms;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence model;Behavior;Bioinformatics;biomedical informatics;Blindness;career;career development;Cataract;Choroidal Neovascularization;Clinical;clinical encounter;clinical practice;Code;cohort;Color;Communication;convolutional neural network;Cornea;COVID-19 pandemic;Data;Databases;deep learning;deep learning model;deep neural network;demographics;Development Plans;Diabetic Retinopathy;Diagnosis;digital;Disease;disorder of macula of retina;Distance Learning;Doctor of Philosophy;Educational Curriculum;Educational workshop;Electronic Health Record;electronic structure;experience;Faculty;Funding;Fundus photography;Glaucoma;Goals;high risk;Image;improved;interest;K-Series Research Career Programs;Knowledge;Length;Light;Link;Logistic Regressions;Machine Learning;machine learning model;Macular degeneration;Mentors;Mentorship;Methodology;Methods;Modeling;Myopia;Natural Language Processing;ophthalmic examination;Optical Coherence Tomography;Outcome;Pathologic;Pathology;patient stratification;Patients;Photography;Physicians;Population;Population Study;predictive modeling;Prevalence;prevent;Prevention;Principal Investigator;programs;prophylactic;Prophylactic treatment;Provider;Radiology Specialty;repaired;Reporting;Research;Retina;Retinal Detachment;Retinal Diseases;retinal imaging;Retinal Perforations;Risk;Risk Factors;risk prediction;risk stratification;Scientist;Sensitivity and Specificity;standard of care;Statistical Methods;Strabismus;Structure;Surgeon;symposium;Symptoms;Testing;Text;Thick;Traction;Training;training opportunity;United States National Institutes of Health;Validation;Vision;Visual;vitreous floater

PROJECT_TITLE: Artificial Intelligence Analysis of Myopic Vitreoretinal Pathology

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (04)]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

ORG_CITY: RICHARDSON

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: PROJECT NARRATIVE Voltage gated sodium channels (VGSCs) are critical gatekeepers of nociceptor excitability that mediate acute and chronic pain. We discovered that VGSC modulatory proteins that evoke resurgent sodium current are expressed in human, but not murine, nociceptors, strongly suggesting that human nociceptors display resurgent sodium currents. This study will exclusively use human dorsal root ganglia and, focusing on resurgent current in nociceptors, characterize sensitization- and pain-dependent alterations in VGSC expression, modulation, and function.

PI_NAMEs: HANKERD, KALI  (contact)

PROGRAM_OFFICER_NAME: OSHINSKY, MICHAEL L

PROJECT_TERMS: Action Potentials;Acute Pain;Address;Affect;Alternative Splicing;Binding Proteins;Bioinformatics;biophysical properties;Biophysics;career;Cells;Chest;chronic pain;Co-Immunoprecipitations;cytokine;Data;Development;Diameter;Electrophysiology (science);Environment;Exhibits;experimental study;Fibroblast Growth Factor;fibroblast growth factor 13;gain of function;gain of function mutation;Ganglia;Gatekeeping;Gene Expression;Gene Targeting;Genes;Growth Factor;Growth Factor Gene;Human;human disease;Human Genetics;immunocytochemistry;in silico;Incidence;Injury;insight;intense pain;Kinetics;knock-down;Knowledge;Mechanoreceptors;Mediating;Membrane;Mentors;Modeling;Molecular;mouse model;Mus;Mutation;neuronal excitability;Neurons;Neurosciences;new therapeutic target;Nociception;Nociceptors;non-opioid analgesic;Operative Surgical Procedures;Organ Donor;Pain;pain sensation;patch clamp;Pattern;Pharmacology;Population;Protein Isoforms;protein protein interaction;protein structure prediction;Proteins;Proteomics;Publishing;Recovery;Resistance;RNA Splicing;Rodent;Role;Sampling;skills;Small Interfering RNA;Sodium;Sodium Channel;Sodium Channel Binding;species difference;Spinal Ganglia;Synapses;System;Technology;Testing;Tetrodotoxin;Training;training opportunity;Transcript;transcriptome sequencing;Variant;virtual;voltage;Work

PROJECT_TITLE: Resurgent Currents in Human Dorsal Root Ganglia


ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The specialized properties of blood vessels in the central nervous system (CNS) facilitate proper neural function by exerting tight control over molecular transport and targeting blood to active regions. Mural cells, which line the outside of blood vessels, contribute to these specialized functions through tissue-specific gene expression, yet we do not know how this genetic program is activated during development. This project will improve fundamental knowledge of these developmental mechanisms, which may illuminate new strategies to prevent CNS mural cell dysfunction in neurological diseases.

PI_NAMEs: GASTFRIEND, BENJAMIN DOMENIC (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Acute;Address;Alzheimer's Disease;angiogenesis;Anterior;ATAC-seq;beta catenin;Biological Assay;Biomedical Research;Blood;Blood - brain barrier anatomy;Blood Vessels;Body System;California;cell regeneration;Cell Survival;Cells;Central Nervous System;Cerebral small vessel disease;Chromatin;Cleavage Under Targets and Release Using Nuclease;Data;Data Set;Development;Diabetic Retinopathy;Disease;dominant active;Electron Microscopy;Endothelial Cells;epigenome;epigenomic profiling;epigenomics;Fellowship;Functional disorder;Future;Gene Expression;Gene Expression Profile;gene regulatory network;Genes;Genetic;Genetic Transcription;Genomics;Glass;Homeostasis;Immunohistochemistry;improved;In Vitro;in vivo;Invaded;Knock-out;Knowledge;Lead;Ligands;Link;Maintenance;Mediating;Mentors;Mesoderm;Metabolism;Molecular;molecular phenotype;Molecular Profiling;Molecular Target;mouse model;Mus;nerve stem cell;Nervous System Disorder;neural;Neural Crest;Neurophysiology - biologic function;neurotransmission;neurotrophic factor;neurovascular coupling;novel;Organ;overexpression;Pathologic;Pathway interactions;Pericytes;Phenotype;Postdoctoral Fellow;prevent;Process;programs;Property;Prosencephalon;Regulatory Element;repaired;Reporter;Research;Research Project Grants;Retina;Role;Signal Transduction;skills;Smooth Muscle Myocytes;solute;synergism;Techniques;Testing;Therapeutic;Tissue-Specific Gene Expression;Tissues;Training;transcription factor;transcriptome;transcriptomic profiling;Transport Process;Universities;Vascular Smooth Muscle;virtual;WNT Signaling Pathway;Work

PROJECT_TITLE: Development of Tissue-Specific Properties in Central Nervous System Mural Cells


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE This project is relevant to public health given that environmental insults and oxidative stress drive telomere damage and promote cardiac dysfunction. Here, we will investigate how oxidative damage at telomeres affects mitochondria and metabolism to drive cellular senescence. Deciphering the molecular interactions governing telomere status in response to environmental insults is expected to uncover therapeutic targets that could prevent the progression of cardiac diseases.

PI_NAMEs: GURKAR, ADITI U (contact)

PROGRAM_OFFICER_NAME: HEACOCK, MICHELLE

PROJECT_TERMS: 3-Dimensional;Ablation;Action Potentials;Affect;Age;age related;Aging;Architecture;autocrine;Base Excision Repairs;Binding;Biochemical;Biological;Calcium;Cardiac;Cardiac health;Cardiac Myocytes;cardiac tissue engineering;Cardiovascular Diseases;Cardiovascular system;Cell Aging;Cell Communication;Cell Physiology;cell type;Cells;Communication;Complex;CRISPR/Cas technology;Data;design;Detection;Disease;DNA Damage;Dose;early onset;Electrophysiology (science);Environment;Environmental Exposure;Environmental Risk Factor;exhaustion;Fibroblasts;Frequencies;Functional disorder;G-Quartets;genome editing;Goals;Heart;Heart Diseases;heart function;Homeostasis;human induced pluripotent stem cells;Immunofluorescence Immunologic;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;innovation;insight;Investigation;Length;Lesion;Link;Machine Learning;Maps;Measures;Metabolism;millisecond;Mitochondria;mitochondrial dysfunction;Molecular;Monitor;Mus;Myocardial dysfunction;nanofabrication;Nature;new therapeutic target;novel;OGG1 gene;Organoids;Outcome;Output;oxidative damage;Oxidative Stress;Oxidative Stress Induction;paracrine;Pathologic;Pathway interactions;Pattern;pharmacologic;Phenotype;Physiological;postmitotic;Predisposition;prevent;Public Health;Qualifying;repair enzyme;repaired;Reporting;Resolution;response;Role;senescence;senescent cell;sensor;Signal Pathway;Site;Source;spatiotemporal;spheroids;Stress;System;telomere;telomere damage;Telomere Shortening;temporal measurement;TERF1 gene;Testing;therapeutic target;Time;Tissues;tool;Treatment Protocols;two-dimensional;Work

PROJECT_TITLE: Telomere dysfunction driven molecular outputs in the cardiac unit

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LWJ-K (TL)]


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Data Science;Genetics;Lung;Precision Medicine;Women's Health Research

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Rigorous consideration of sex and gender have not been routine in data science, Network Medicine, and Patient Oriented Research in lung disease. Addressing COPD through a sex and gender lens will promote translation of big data to actionable clinical innovations for women and men; investigation of association between mosaic chromosomal alterations of X and loss of Y chromosomes with COPD phenotypes, integration with Omics data and with gene regulatory networks will support advancing this goal. Mentoring and dissemination of sex and gender approaches to data analytics will inform strategies for Precision Pulmonary Medicine.

PI_NAMEs: DEMEO, DAWN L (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: Address;affection;age-related disease;Aging;Area;Automobile Driving;Awareness;Big Data;Biological;biological sex;Biology;career;career development;Cause of Death;Chromosome abnormality;chromosome Y loss;Chronic Obstructive Pulmonary Disease;Clinical;clinically actionable;cohort;Consultations;Data;Data Analyses;Data Analytics;data dissemination;Data Science;Data Scientist;Data Security;Development;Disease;DNA Methylation;Epidemiology;Epigenetic Process;Evaluation;Exclusion;Exhibits;Faculty;Female;Funding;Gender;gender difference;Gene Expression;gene regulatory network;Genes;Genetic;Genomics;Goals;Health;improved;Informatics;innovation;insight;interest;Investigation;investigator training;Leadership;lens;Life;Lung;Lung CAT Scan;Lung Diseases;lung health;male;Malignant neoplasm of lung;Mediating;Medical Students;Medicine;men;Mentors;Mentorship;Methods;Modeling;Molecular;mosaic;Mosaicism;Multiomic Data;multiple omics;National Heart, Lung, and Blood Institute;Network-based;next generation;novel;Obstructive Lung Diseases;Pathogenesis;Pathway interactions;patient oriented research;Phenotype;Precision Medicine Initiative;Process;programs;Proteomics;Pulmonary Emphysema;pulmonary function;Pulmonology;Reproducibility;Research;Research Personnel;Research Support;Risk;Science;Scientist;sex;sex as a biological variable;Sex Bias;Sex Chromosomes;Sex Differences;success;Symptoms;tool;Training;Training Support;Trans-Omics for Precision Medicine;Translations;treatment response;Woman;Women's Health;Work;X Chromosome;Y Chromosome

PROJECT_TITLE: Mentoring in Patient Oriented Research in Lung Disease through a Sex and Gender Lens


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PHR: Project Narrative  An effective and long-lasting vaccine will be essential to eliminate and eradicate malaria, a disease that afflicts more than 200 million people every year. The proposed research delves into humoral immunity to the PfSPZ vaccine, the only malaria vaccine with >90% protective efficacy, and how protective immune responses may differ in people who have already been infected with malaria. These insights will help us design the next generation of malaria vaccines that will be highly effective in the United States and Sub-Saharan Africa.

PI_NAMEs: HERMAN, JONATHAN DAVID (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Affect;Africa;Africa South of the Sahara;Anti-malarials;Antibodies;Antibody Response;Antibody titer measurement;Antigenic Variation;Antigens;antimicrobial;Antiparasitic Agents;Area;Binding;Bioinformatics;Biological Models;Biophysics;career development;CD8-Positive T-Lymphocytes;Cells;Cellular Immunology;Cessation of life;Child;Chronic;circumsporozoite protein;Clinical;Complement;Complement 1q;Complement-Dependent Cytotoxicity;Data Analyses;Dependence;design;Development;Development Plans;Disease;Drops;Erythrocytes;experience;Exposure to;Funding;genetic variant;Genomics;Hospitals;Human;Humoral Immunities;IgG1;Immune response;Immunity;Immunodominant Antigens;Immunodominant Epitopes;Immunoglobulin G;Immunoglobulin M;Immunology;improved;Individual;Infection;Information Systems;insight;instructor;Invaded;Investigation;Laboratories;Learning;Liver;Malaria;malaria infection;Malaria Vaccines;Measures;Mediating;medical schools;Medicine;Mentors;mid-career faculty;Monoclonal Antibodies;Mosquito-borne infectious disease;Mus;National Institute of Allergy and Infectious Disease;next generation;novel;Parasites;pathogen;Pathogenesis;Patients;Persons;Phage Display;Physicians;Plasmodium;Plasmodium falciparum;Plasmodium falciparum vaccine;Population;professor;programs;Property;protective efficacy;Proteins;Proteome;rational design;Recombinants;Research;response;responsible research conduct;Role;Running;Scientist;Serology;Serology test;Serum;Sporozoite vaccine;Sporozoites;System;Systems Biology;Time;tool development;Training;United States;Universities;Vaccination;Vaccine Design;vaccine efficacy;Vaccinee;Vaccines;vaccinology;Variant;Washington;Woman;Work

PROJECT_TITLE: Systems Antibody Immunology of the Malaria Sporozoite Vaccine

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

ORG_CITY: Princeton

ORG_DEPT: MISCELLANEOUS

ORG_NAME: PRINCETON UNIVERSITY

PHR: Project Narrative Microtubules of the mitotic spindle orchestrate equal segregation of chromosomes during cell division. This work will reveal how mitotic spindles are generated during mitosis in animals and trypanosome parasites. By determining how different species make their spindles, we will better understand not only mitosis, a critical event in the lifecycle of the cell, but also can develop new treatments for parasitic infection.

PI_NAMEs: TRAVIS, SOPHIE M. (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Actins;African Trypanosomiasis;Animals;Area;Binding;Binding Sites;Biological Assay;Biological Models;Biology;Cell Cycle;Cell division;Cell Nucleus;Cells;Centrosome;Chromosome Segregation;Chromosomes;Collaborations;Communities;Complex;Cryo-electron tomography;Cryoelectron Microscopy;Cytoplasm;Cytoskeleton;Discipline;egg;Electron Microscopy;Eukaryota;Event;experimental study;Filament;Freezing;Gamma-Tubulin Ring;global health;Incubated;Institution;Ions;kinetosome;Label;Lead;Learning;Leishmaniasis;Life Cycle Stages;light microscopy;Mass Spectrum Analysis;Membrane;Mentors;Mentorship;Metaphase;Microtubule Stabilization;Microtubule-Organizing Center;Microtubules;Mitosis;Mitotic;Mitotic spindle;Modeling;Mutation;novel therapeutics;Nuclear;Nuclear Envelope;Organelles;Orthologous Gene;Parasites;Parasitic Diseases;Parasitic infection;particle;Phase;Plants;Positioning Attribute;Postdoctoral Fellow;preservation;Process;protein complex;Proteins;Recombinants;reconstitution;recruit;Regulation;Research;Research Personnel;Shapes;Side;single molecule;Site;Space Perception;structural biology;Structure;Techniques;Testing;Therapeutic;Time;Tomogram;Total Internal Reflection Fluorescent;trafficking;Training;Trypanosoma;Trypanosoma brucei brucei;Vesicle;Visualization;Work;Xenopus;Xenopus laevis;Yeasts

PROJECT_TITLE: How to make a microtubule organizing center

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-8 (KR)]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

PHR: PROJECT NARRATIVE Transcription factors are proteins which play key roles in a variety of biological processes and many human diseases, including cancer. Most transcription factors are expressed not as a single protein, but rather as a series of distinct protein “isoforms”, yet the vast majority of transcription factor isoforms—thousands of proteins—remain entirely uncharacterized. The proposed project will develop approaches to probe the roles of thousands of transcription factor isoforms at once in breast cancer cells, which will uncover novel disease- relevant biology and lay the foundation for studying isoforms more broadly, genome-wide and in other cellular contexts.

PI_NAMEs: MATTIOLI, KAIA  (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Award;Awareness;Bar Codes;Binding;Biochemical;Bioinformatics;Biological Assay;Biological Process;Biology;Breast Cancer Cell;Breast Cancer cell line;Cancer Cell Growth;Cancer cell line;candidate identification;career development;Cell Differentiation process;cell growth;Cell Line;Cell Physiology;Cells;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Computer Analysis;CRISPR screen;CRISPR/Cas technology;Custom;dark matter;Data;Data Set;Databases;Dependence;design;Development;differential expression;Disease;DNA;DNA Binding;Dominant-Negative Mutation;Doxycycline;Enzymes;Exhibits;experimental study;Foundations;functional genomics;Future;Gene Expression;Gene Expression Regulation;gene function;gene regulatory network;Genes;Genetic Transcription;genome-wide;Genomic approach;Genomics;Goals;Grant;Growth;Guide RNA;high throughput screening;Human;human disease;Human Genome;Individual;knock-down;Knock-out;Learning;Libraries;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Mammalian Cell;Maps;Mentors;Messenger RNA;Methods;Modeling;novel;Open Reading Frames;overexpression;Phase;Phenotype;Physiological;Play;Positioning Attribute;Postdoctoral Fellow;promoter;Property;Protein Isoforms;protein protein interaction;Proteins;Regulator Genes;Research;RNA;RNA Interference;RNA Splicing;Role;screening;Series;single cell sequencing;Structure;System;Technology;technology development;Testing;Training;Transcript;transcription factor;Transcriptional Activation;transcriptome;transcriptome sequencing;Translating;tumorigenesis;Work

PROJECT_TITLE: Functional genomics approaches to decode the roles of transcription factor isoforms

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Aging;Diabetes

PHR: PROJECT NARRATIVE This research is relevant to public health because a lower insulin-stimulated glucose disposal by skeletal muscle is linked to many of the most prevalent and devastating age-related disorders in older people. It is crucial to understand how to improve the insulin sensitivity in skeletal muscle of older individuals. The new knowledge from this project has the potential to inform and inspire the development and optimization of strategies to improve the health of older people.

PI_NAMEs: CARTEE, GREGORY D. (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: 5'-AMP-activated protein kinase;Adoption;Adult;Age;Age related pathologies;age-related disease;Aldehyde-Lyases;Alternative Therapies;Alzheimer's Disease;anti aging;Binding;Blood Glucose;blood glucose regulation;Caenorhabditis elegans;Caloric Restriction;Calories;Cardiovascular Diseases;Cell model;Cell surface;Coronary heart disease;Cultured Cells;Defect;design;Development;Diabetes Mellitus;extend lifespan;Fructose;Glucose;glucose disposal;Glucose Transporter;glucose uptake;Glucose-6-Phosphate;glucose-regulated proteins;GLUT 4 protein;Goals;GTPase-Activating Proteins;Health;healthy aging;Heart Hypertrophy;Human;human old age (65+);Hypertension;Impaired cognition;improved;inhibitor;insight;Insulin;Insulin Resistance;insulin sensitivity;Intake;Knowledge;Link;Location;Lysosomes;Malignant Neoplasms;Mitochondria;Mus;Muscle;Non-Insulin-Dependent Diabetes Mellitus;novel;Older Population;Outcome;paralogous gene;Phosphorylation;Play;Prevalence;Protein-Serine-Threonine Kinases;Proteins;Public Health;rab GTP-Binding Proteins;Rattus;Regulation;Research;Risk;Rodent;Serine;side effect;Signaling Protein;Site;Skeletal Muscle;Stroke;Tissues

PROJECT_TITLE: Non-canonical Mechanisms and Unconventional Approaches to Activate AMPK and Glucose Uptake in the Skeletal Muscle of Older Rats

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

PHR: PROJECT NARRATIVE The proposed studies will investigate the mechanisms that govern immune response to the brain tumor, glioblastoma. These mechanistic insights will help to inform the development of potential new combination therapeutic strategies for manipulating the specific immune cells, macrophages, in order to enhance anti-tumor immune response. This career development award will provide the applicant with high-level training and thereby allow her to launch an independent research career aimed at improving outcomes for patients suffering from brain tumors.

PI_NAMEs: HOFSTATTER AZAMBUJA, JULIANA  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Advisory Committees;Affect;aggressive therapy;Agonist;antagonist;anti-tumor immune response;Award;BCL10 gene;Behavior;Biological Markers;Blood - brain barrier anatomy;Brain Glioblastoma;Brain Neoplasms;C Type Lectin Receptors;Cancer Center;career;Cell Communication;Cells;chemotherapy;Complex;Data;Dedications;Development;Drug Delivery Systems;Educational Status;effectiveness evaluation;efficacy evaluation;experimental study;Fostering;Foundations;Glioblastoma;Human;Immune;Immune response;Immune system;Immunooncology;immunoreactivity;Immunosuppression;improved;improved outcome;In Vitro;in vivo;Individual;Infiltration;Inflammatory;innovation;insight;K-Series Research Career Programs;Knock-out;Lead;Libraries;Macrophage;Macrophage Activation;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Mediator;Medical;Mentors;Microglia;Modeling;Molecular;Mucosa- associated lymphoid tissue lymphoma translocation protein-1;Mus;Myeloid Cells;Myeloproliferative disease;Nature;neoplastic cell;neuro-oncology;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Operative Surgical Procedures;Organoids;Outcome;Patient-Focused Outcomes;Patients;Phase;Phenotype;Play;Postdoctoral Fellow;pre-clinical;Primary Brain Neoplasms;Prognosis;programs;protein complex;Radiation therapy;Radio;receptor;recruit;Research;Research Personnel;Resources;response;Role;Scaffolding Protein;Signal Transduction;Signaling Protein;Solid Neoplasm;Survival Rate;targeted treatment;Therapeutic;Therapeutic Effect;Therapeutic Intervention;therapeutic target;therapeutically effective;therapy resistant;Training;Treatment outcome;Treatment Protocols;treatment response;treatment strategy;tumor;tumor growth;tumor heterogeneity;Tumor Immunity;tumor microenvironment;tumor progression;Tumor-associated macrophages;tumor-immune system interactions;tumorigenic;Universities;Work

PROJECT_TITLE: Harnessing Tumor Associated Macrophages in Glioblastoma

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: FRIENDSWOOD

ORG_NAME: SPARK BIOMEDICAL INC

PHR: PROJECT NARRATIVE The use of opioids in the US has created an opioid crisis that killed over 80,816 people in 2021. To aid in opioid cessation and opioid use disorder (OUD) treatment retention, new therapies are needed to both monitor and treat opioid withdrawal symptoms. Spark Biomedical proposes the combination of physiologic sensing and transcutaneous auricular neurostimulation (tAN) to deliver tailored opioid withdrawal treatment. In this proposal, we will collect wearable sensor data from adults with opioid use disorder entering detox treatment to develop a closed-loop machine learning algorithm that detect opioid withdrawal and cravings and triggers delivery of tAN.

PI_NAMEs: KHODAPARAST, NAVID  (contact)

PROGRAM_OFFICER_NAME: SABIRZHANOV, BORIS YEVGENYEVICH

PROJECT_TERMS: Accelerometer;Acute;Adult;Agonist;algorithm development;Algorithms;Ambulatory Care;American;analog;application programming interface;barrier to care;Biological Markers;Buprenorphine;Clinical;Clinical Trials Design;cloud based;commercialization;Couples;craving;Cutaneous;Data;Data Collection;Decision Trees;design;Detection;Development;Devices;Ear;Economic Burden;Environment;Feedback;Future;Goals;Health Services Accessibility;Heart Rate;heart rate variability;high risk;Hydrocortisone;Inpatients;lofexidine;Machine Learning;machine learning algorithm;Marketing;Measures;Medical;Medical Device;Methadone;Monitor;Nerve;novel therapeutics;Opioid;opioid epidemic;opioid mortality;opioid overdose;opioid use;opioid use disorder;opioid withdrawal;Outpatients;Overdose;Patient Monitoring;Patients;Persons;Pharmacotherapy;Phase;Physiological;Prevention;Randomized, Controlled Trials;recruit;Regulatory Pathway;relapse prevention;Residential Treatment;sensor;smart watch;software systems;Sparrows;Structure;success;Supervision;System;targeted treatment;Temperature;Testing;Training;treatment center;Trigeminal nerve structure;United States;Visual;wearable data;wearable device;wearable sensor technology;Withdrawal Symptom

PROJECT_TITLE: Development of a Machine Learning Algorithm to Detect Opioid Withdrawal and Cravings to Increase Treatment Retention

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SAI-S (A1)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE There are ~ 1 billion human influenza virus cases worldwide each year that cause up to 650,000 deaths. Influenza virus infection remains difficult to treat because the antiviral drugs available are usually limited to preventing influenza virus infection early in the infection and increasing drug resistance limits their effectiveness. We have identified an E3 ligase MARCH10 that targets an influenza virus virulence factor for degradation and propose in vitro and in vivo studies with the ultimate goal of developing new therapies to combat influenza virus infection.

PI_NAMEs: TSAI, MUCHUN  (contact)

PROJECT_TERMS: Acute Lung Injury;adeno-associated viral vector;Advisory Committees;Affect;airway epithelium;animal model development;Anti-viral Agents;Binding;Binding Proteins;Biological;Biology;bronchial epithelium;career development;Cell membrane;Cells;Cellular biology;Cessation of life;Clinical;combat;Data;design;Development Plans;Distal;Down-Regulation;Drug resistance;Effectiveness;Elements;Enzymes;Epithelial Cells;Family;Fingers;Future;Genes;Genetic Transcription;Goals;Hemagglutinin;HIV;Host Defense;Human;Immune;Immunity;Immunology;In Vitro;in vivo;Infection;Influenza;Influenza Hemagglutinin;influenza infection;influenza M2;Influenza prevention;Influenza Virus Infected Cells;influenza virus strain;influenzavirus;innate immune pathways;Innate Immune Response;Integration Host Factors;Lung;lung injury;Measures;Mediating;Membrane;Membrane Proteins;Mentors;Messenger RNA;Molecular;Molecular Biology;mRNA Expression;mRNA Stability;Mus;mutant;Natural Immunity;Neuraminidase;novel;novel therapeutics;Orphan;Outcome;overexpression;pandemic influenza;particle;Pathogenesis;Peer Review;Physicians;Plasmids;Post-Translational Protein Processing;posttranscriptional;Predisposition;prevent;Preventive treatment;Principal Investigator;promoter;Promoter Regions;protein expression;Proteins;receptor;Recommendation;Regulation;Reporter;Role;Scientist;seasonal influenza;Severities;Site;Surface;Techniques;Therapeutic;Training;Training Programs;Translating;Ubiquitin;Ubiquitin-mediated Proteolysis Pathway;ubiquitin-protein ligase;Ubiquitination;Viral;Viral Pathogenesis;Viral Proteins;Viral Respiratory Tract Infection;virology;Virulence Factors;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: The Role of E3 Ligase MARCH10 in Influenza Virus Infection

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (OA)]