NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: KISKINIS, EVANGELOS  (contact)

PROJECT_TERMS: Acute;ASCL1 gene;Biological Process;Brain;Cell Line;cell type;Chemicals;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Collaborations;Communities;cost effective;CRISPR/Cas technology;Cryopreservation;Data;Development;Developmental Process;excitatory neuron;Gene Dosage;Generations;Genes;genetic approach;Genetic Diseases;genetic manipulation;Genetic study;genetic variant;Goals;Human;human induced pluripotent stem cells;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;induced pluripotent stem cell technology;inhibitory neuron;Interneurons;Investigation;Letters;member;Missense Mutation;Molecular;Monomeric GTP-Binding Proteins;Morphology;Mus;Mutagenesis;mutant;Mutation;neural circuit;Neurobiology;Neurodevelopmental Disorder;Neuronal Differentiation;Neurons;Nonsense Mutation;Organoids;Pathogenicity;Pathway interactions;Patients;Phenotype;Protein Isoforms;Protocols documentation;Quality Control;Reporting;Services;sex;small molecule;stem cells;Structure;Synapses;synaptic function;SYNGAP1;tool;transcription factor;Variant;Work

PROJECT_TITLE: Neurodevelopmental Stem Cell core


ADMINISTERING_IC: MH

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: CHICAGO

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PI_NAMEs: KEARNEY, JENNIFER A (contact)

PROJECT_TERMS: Affect;Animal Model;Architecture;autism spectrum disorder;Behavior;Behavioral;Biochemical;Biological;Biological Models;Brain;brain tissue;Breeding;cell behavior;cell type;Cells;Cellular biology;Codon Nucleotides;Cognitive;Communities;Complex;cost effective;CRISPR/Cas technology;Data;Decision Making;Deposition;Development;Dissection;Electrophysiology (science);Engineering;Event;experience;Functional disorder;Gene Expression;Gene Expression Regulation;Gene Modified;Generations;Genes;Genetic;genetic manipulation;Genetic study;genetic variant;Genotype;Goals;Growth;Guanosine Triphosphate Phosphohydrolases;Human;in vivo;Induced pluripotent stem cell derived human neuron;Institution;Intellectual functioning disability;Knock-in Mouse;Knowledge;Maintenance;member;migration;Modeling;Molecular;Molecular Analysis;Monomeric GTP-Binding Proteins;Morphogenesis;mouse genome;mouse model;Mus;Mutate;Mutation;network dysfunction;neural circuit;Neurobiology;Neurodevelopmental Disorder;neuronal circuitry;Neurons;novel;optogenetics;Orthologous Gene;Pathway interactions;Play;Process;Quality Control;Regulation;Reporter;Reproducibility;Research;Resource Sharing;Resources;rho;Risk Factors;risk variant;Rodent;Role;Schizophrenia;sensory cortex;Services;shared repository;Signal Pathway;Signal Transduction;Slice;small molecule;Somatosensory Cortex;Standardization;Synapses;Synaptic plasticity;SYNGAP1;System;Therapeutic;Time;tool;Variant

PROJECT_TITLE: Mouse Resource Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-E (01)]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer;Childhood Leukemia;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: HOUSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: RICE UNIVERSITY

ORG_STATE: TX

PHR: NARRATIVE Acute myeloid leukemia (AML), a hematological malignancy, remains stubbornly difficult to treat in both children and adults, with fewer than 30% of patients surviving five years after diagnosis. This project tests a novel treatment target (mitochondrial recycling—aka mitophagy) and novel small molecules identified using cheminformatics, in AML cell lines and primary cells. This project will facilitate the identification and characterization of promising leads for the development of future therapies.

PI_NAMEs: KIRIENKO, NATASHA  (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: Acute leukemia;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adult;Affect;Aftercare;Age Years;Agonist;analog;Antineoplastic Agents;Apoptosis;Apoptotic;Automobile Driving;Bioinformatics;Biological;Biological Assay;Blast Cell;Blood Cells;Bone Marrow;Bone Marrow Cells;cancer cell;Cell Death;Cell Death Inhibition;Cell Differentiation process;Cell division;Cell Line;Cell Proliferation;Cell Survival;Cells;Cessation of life;Chemical Structure;Chemicals;cheminformatics;Child;Coupling;cytotoxic;cytotoxicity;Data;Defect;Development;Diagnosis;Disease remission;Doxorubicin;effective therapy;Engraftment;exhaustion;experimental study;Family;Family member;Foundations;Future;Genetic;genetic approach;Glutathione;Glutathione Reductase;Health;Hematologic Neoplasms;high throughput screening;Homeostasis;Human;human old age (65+);Immune;improved;in silico;innovation;Lead;leukemia;leukemia treatment;Leukemic Cell;leukemic stem cell;life span;Malignant - descriptor;Mammalian Cell;Measures;Mediating;member;Metabolic;Metabolism;metabolomics;meter;Mitochondria;Molecular Target;mortality;mouse model;Mus;Names;Newly Diagnosed;novel;older patient;Oxidation-Reduction;Oxygen Consumption;Parkin;Pathway interactions;patient derived xenograft model;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phenotype;Phosphotransferases;PINK1 gene;preclinical study;Probability;Production;Prognosis;Publishing;Recycling;Relapse;Research;screening;side effect;small molecule;Solubility;stem cells;Structure;Structure-Activity Relationship;synergism;System;Testing;Therapeutic;Toxic effect;Toxin;transcriptomics;Treatment Efficacy;Tumor Burden;TXN gene;Validation;Work

PROJECT_TITLE: Cheminformatics-based identification of leukemia-targeting molecules

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-K (J2)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision

ORG_CITY: BOISE

ORG_DEPT: PHYSICS

ORG_NAME: BOISE STATE UNIVERSITY

ORG_STATE: ID

PHR: Project Narrative: Several studies show that α-crystallin binding to the lens membrane increases with age and cataract; however, the mechanism that initiates α-crystallin binding to the lens membrane is unknown. We hypothesize that deamidation and mutation of α-crystallin and oxidation of lipids and cholesterol promote α- crystallin binding to the membrane, and cholesterol and cholesterol bilayer domains inhibit such binding and protect against cataract formation and progression. These studies will determine the mechanism of α-crystallin binding to the lens membranes that will enable alternative strategies for preventing, curing, and slowing cataract progression.

PI_NAMEs: MAINALI, LAXMAN  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Affinity;Age;age related;Aging;Atomic Force Microscopy;Binding;Cataract;Cell membrane;Cholesterol;Crystalline Lens;Crystallins;Cytoplasm;deamidation;Development;DNA Sequence Alteration;early onset;Electron Spin Resonance Spectroscopy;fiber cell;Funding;Grant;Health;Human;Hydrogen Peroxide;Hydrophobicity;Image;Individual;innovation;Integral Membrane Protein;Knowledge acquisition;lens;lens transparency;light scattering;Lipids;Measures;Membrane;membrane model;Methods;Molecular;Molecular Chaperones;mutant;Mutate;Mutation;Nuclear Envelope;oxidation;Paper;Phospholipids;physical property;prevent;protein aggregation;Proteins;Publishing;Race;Recording of previous events;Reporting;Research;Role;sex;Sphingolipids;Stress;System;Testing;Work;α-Crystallins

PROJECT_TITLE: Interaction of alpha-crystallin with cholesterol bilayer domains in cataract formation

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: DURHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Increasing prevalence and disparities in obesity, heart disease, diabetes, and obesity-related diseases pose a threat to current and future generations’ health. Excessive weight gain during infancy is an important factor in the development of obesity and obesity-related diseases, yet we do not have adequate strategies to help promote healthier weight gain among bottle-fed infants. Our study tests new interventions related to infant bottles that are designed to help caregivers feed more responsively and help reduce excessive weight gain during early infancy.

PI_NAMEs: WOOD, CHARLES T (contact)

PROGRAM_OFFICER_NAME: BROCKWAY, HEATHER MARIE

PROJECT_TERMS: acceptability and feasibility;Adherence;Adolescent;Adult;Affect;Age Months;Attenuated;Biometry;Birth;Bottle feeding;Breast Feeding;Breastfed infant;Cardiometabolic Disease;Cardiovascular Diseases;Caregivers;Cessation of life;Characteristics;Child;Clinical;Clinical Trials;community intervention;community setting;Consumption;Cues;Data;design;Diabetes Mellitus;Disparity;disparity reduction;early childhood;Education;effective intervention;efficacy evaluation;efficacy testing;Eligibility Determination;eligible participant;Enrollment;ethnic disparity;ethnic minority population;excessive weight gain;Exhibits;Family;feeding;Feeding behaviors;Feeds;Future Generations;Growth;Guidelines;Health;healthy weight;Heart Diseases;high risk;Home;Human Milk;Hunger;improved;Incidence;Individual;infancy;Infant;Intervention;Joints;Kilogram;Left;Length;Life;Measures;Metabolic Diseases;Milk;Morbid Obesity;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;novel;novel strategies;Obesity;Obesity associated disease;obesity development;obesity in children;obesity prevention;obesity treatment;Participant;participant enrollment;Positioning Attribute;Prevalence;prevent;Primary Care;primary care clinic;primary care setting;Primary Prevention;racial disparity;racial minority population;Randomized;randomized trial;rapid weight gain;Recommendation;Research;Risk;Risk Factors;Satiation;Surveys;Testing;therapy design;Translations;United States;Video Recording;Visual;Weight;Weight Gain;Work

PROJECT_TITLE: AB3: Assessing Better Bottles for Babies

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative Epithelioid hemangioendothelioma (EHE), a rare cancer with no effective treatment, is caused by a protein produced by the fusion of two genes, TAZ (WWTR1) and CAMTA1 that we call TC (abbreviation for TAZ- CAMTA1). Using EHE cancer cells, we screened FDA-approved drugs and identified dinaciclib as a potent TC inhibitor. We propose studies to test the efficacy of dinaciclib in mouse models of EHE and to elucidate its mechanism of action, with the goal of repurposing dinaciclib for the first effective EHE treatment.

PI_NAMEs: POBBATI, AJAYBABU ;RUBIN, BRIAN P (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Abbreviations;addiction;Address;Aftercare;Allografting;Apoptosis;Binding;cancer cell;Cancer Etiology;cancer therapy;CDKN2A gene;Cell Line;Cell model;Cell Nucleus;Cell Proliferation;Cells;Chemicals;Chromosomal translocation;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;conditional knockout;Cyclin-Dependent Kinase Inhibitor;Cyclin-Dependent Kinase Inhibitor 2A;Cyclin-Dependent Kinases;Cytoplasm;Data;Development;Diagnosis;Disease;effective therapy;efficacy evaluation;efficacy testing;Engineering;ERCC3 gene;Event;FDA approved;forging;fusion gene;Genes;Genetic;Genetic Transcription;Genetically Engineered Mouse;Goals;Hemangioendothelioma;Human;Immunofluorescence Immunologic;Immunoprecipitation;In Vitro;Indolent;inhibitor;innovation;Link;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Modeling;Molecular;Molecular Target;mortality;mouse model;Mus;Mutation;Nuclear;Oncogenes;Oncogenic;Outcome;p19ARF;Patient Care;Patients;Pharmaceutical Preparations;Phenotype;Phosphorylation;Physiological;Positioning Attribute;pre-clinical;Preclinical Testing;prevent;Process;Productivity;Proteins;rare cancer;Resources;RNA Processing;Role;screening;small molecule;standard of care;targeted agent;Testing;Therapeutic;Transcription Elongation;Translating;triptolide;tumor;Tumor Biology;Tumor Cell Line;Tumor Suppressor Proteins;tumorigenesis;Work

PROJECT_TITLE: Forging a new path with cyclin-dependent kinase inhibitors to treat epithelioid hemangioendothelioma

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-P (J2)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: OVERALL –NARRATIVE Organ transplantation has become a gold standard therapy for older patients with end-stage organ diseases. The goal of this proposal is to delineate mechanisms controlling transplant immunity in aging. A better understanding of the mechanisms by which aging affects transplant immunity is crucial for the development of aged specific immune therapies in transplantation.

PI_NAMEs: ABDI, REZA  (contact)

PROGRAM_OFFICER_NAME: KEHN, PATRICIA J

PROJECT_TERMS: Address;Affect;age related;age related changes;aged;Aging;aging population;Antibodies;Antibody Response;antibody-mediated rejection;antiviral immunity;Attenuated;B-Lymphocytes;Biology;CD4 Positive T Lymphocytes;Cell Aging;Cells;Cellular Immunity;Cellular Metabolic Process;Clinical;Clinical Research;cohort;Collaborations;collaborative approach;Data;Dendritic Cells;design;Development;Disease;efficacy evaluation;Environment;Exclusion;FOXP1 gene;Genetic Transcription;Glutamate Metabolism Pathway;Glutamine;Goals;Graft Survival;Heart Transplantation;Immune;immune imaging;Immune response;Immune system;Immune Tolerance;Immunity;immunomodulatory strategy;immunoregulation;Immunosuppression;Immunosuppressive Agents;Immunotherapy;improved;Inflammaging;Inflammatory;inflammatory milieu;inhibitor;innovation;isoimmunity;Life;Life Expectancy;lymph nodes;lymphotoxin beta receptor;Manuscripts;Mediating;member;Metabolic;Microsurgery;Molecular;mouse model;Mus;nano;Nanodelivery;nanotherapeutic;nephrotoxicity;novel;novel strategies;old mice;older patient;Older Population;Organ;organ transplant rejection;Organ Transplantation;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;Pharmaceutical Preparations;Positioning Attribute;Process;Protocols documentation;Publishing;Receptor Signaling;Regulation;Rejuvenation;Research Personnel;Resistance;response;Reticular Cell;Role;Scientist;senescence;senescent cell;senolytics;Site;skills;Solid;Stress;synergism;T-Lymphocyte;T-Lymphocyte Subsets;targeted delivery;Technology;Testing;therapeutic nanoparticles;Time;transplant model;Transplant Recipients;Transplantation;Transplantation Surgery;Tumor Necrosis Factor-Beta;Work

PROJECT_TITLE: Aging and transplant immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 MMO-I (J2)]


NIH_SPENDING_CATS: Aging;Transplantation

PROJECT_TERMS: Accounting;Adherence;Aging;animal care;Animal Welfare;Bibliography;Budgets;Communication;Data;data integration;data sharing;Disputes;Ensure;Expenditure;Funding;Generations;Goals;Grant;IACUC;Immunity;Individual;Institution;Institutional Review Boards;Laboratories;Maintenance;Manuscripts;meetings;member;Monitor;Occupational activity of managing finances;performance site;Preparation;preservation;programs;Progress Reports;Protocols documentation;Records;Regulation;Research;Research Personnel;Resolution;Scientific Advances and Accomplishments;scientific organization;Shipping;Specialist;Structure;success;symposium;synergism;Transplantation;Travel;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Administrative Core


PHR: CORE B- Narrative Core B will be responsible for synthesizing and characterizing the nanoparticles, encapsulation of payloads, and antibody conjugation. Core B will also carry out immune imaging studies related to T and B cell trafficking to lymph nodes. Core B will be utilized by all three projects.

PROJECT_TERMS: absorption;Address;Adoptive Transfer;aged;Aging;aging related;Alloantigen;allograft rejection;antibody conjugate;Artificial nanoparticles;B-Lymphocytes;Behavior;Binding;Biology;Biomedical Engineering;Blood Vessels;Cells;Charge;Conjugated Carrier;Data;Dendritic Cells;Deposition;Dimensions;Drug Delivery Systems;Drug Targeting;Dyes;Encapsulated;Exocytosis;fiber cell;Glycoproteins;Goals;Graft Rejection;Heart Transplantation;High Endothelial Venule;Homes for the Aged;Homing;Image;Imaging Device;imaging study;Immune;immune activation;immune imaging;Immune response;Immune Targeting;Immune Tolerance;Immunity;immunoregulation;Immunotherapeutic agent;Immunotherapy;in vivo;innovation;insight;interest;intradermal injection;intravenous injection;isoimmunity;Kinetics;L-Selectin;lymph node microenvironment;lymph nodes;Lymphatic;Lymphocyte;Methods;migration;Modeling;Molecular;Monoclonal Antibodies;Mouse Strains;multidisciplinary;nano;Nanodelivery;nanoformulation;nanomedicine;nanoparticle;nanoproducts;nanotherapy;Nature;novel;Organ;particle;Pathogenesis;Peripheral;Pharmaceutical Preparations;Phenotype;Play;programs;Property;Quality Control;Reaction;Regulatory T-Lymphocyte;response;Reticular Cell;Role;Route;Series;Shapes;Signal Transduction;Site;small molecule;stem;Stimulus;Stromal Cells;Surface;surface coating;T memory cell;T-Lymphocyte;targeted delivery;Therapeutic;Therapeutic Uses;Tissues;TNFSF5 gene;Tonsil;trafficking;Transgenic Mice;Transplantation;Transplantation Tolerance;Veins;virtual;Visualization

PROJECT_TITLE: Nano Immune-Imaging Core


PHR: CORE C- Narrative  Core C will be responsible for performing expert microsurgical procedures assuring reproducibility as a pre-requisite of reliable experimental readouts. Core C will coordinate all microsurgical procedures among Projects 1, 2 and 3 to maximize the use of samples while minimizing the number/cost of animals needed for interlocked experiments. Core C will be also responsible for education, training, and animal care of all microsurgical procedures. This core will also provide support for IACUC submissions, amendments in addition to safety and humane animal care.

PI_NAMEs: TULLIUS, STEFAN GUNTHER (contact)

PROJECT_TERMS: age effect;Aging;Amendment;Anastomosis - action;Anesthesia procedures;animal care;animal old age;Animals;Antibodies;Archives;B-Lymphocytes;Biological;Blood;Caring;Cell Aging;Clinical;clinically relevant;Collection;cost;Data;Dedications;Development;Education;Ensure;experience;experimental study;Goals;Graft Rejection;Heart Transplantation;Hemorrhage;Human;Human Resources;IACUC;Immunity;Immunologist;immunosenescence;Injections;Institutional Review Boards;Intervention;Intra-abdominal;Intravenous infusion procedures;Ischemia;isoimmunity;Kidney Transplantation;Length;Mediating;Methods;Microsurgery;Modeling;Monitor;mouse model;multidisciplinary;Mus;Operative Surgical Procedures;Organ Transplantation;Outcome;Pharmaceutical Preparations;post-transplant;Procedures;Protocols documentation;Recording of previous events;Recurrence;Reproducibility;Research;retransplantation;Retrieval;Safety;Sampling;Skin Transplantation;Specimen;success;Surgeon;Surgical Models;T memory cell;T-Lymphocyte;Technical Expertise;Tissue Procurements;Tissues;Training;transplant model;Transplant Surgeon;Transplantation;Transplantation Surgery

PROJECT_TITLE: Microsurgery Core


PROJECT_TERMS: age related;age related changes;aged;Aging;aging related;Agonist;Alloantigen;Ants;B-Lymphocytes;Caring;CDKN2A gene;Cell Aging;Cell Therapy;cell transformation;Cells;chemokine;Chief Cell;Cicatrix;Collagen;conditional knockout;Cyclin-Dependent Kinase Inhibitor;Data;Death Rate;demographics;Dendritic Cells;Development;Down-Regulation;Effector Cell;effector T cell;Elderly;Endothelial Cells;Enhancers;Equilibrium;experience;experimental study;Extracellular Matrix;Fiber;Generations;Genes;heart allograft;Heart Transplantation;Homing;Homologous Gene;Human;Immune;Immune Tolerance;Immunity;immunoregulation;improved;In Vitro;Incidence;Inflammatory;inflammatory milieu;inhibitor;Injections;innovation;isoimmunity;Knockout Mice;lymph node microenvironment;lymph nodes;Lymphoid Tissue;lymphotoxin beta receptor;Mediating;metabolomics;Modeling;Monitor;Monoclonal Antibodies;Mus;Myofibroblast;Nanodelivery;novel;novel strategies;novel therapeutic intervention;novel therapeutics;old mice;older adult;Older Population;Organ failure;Organ Transplantation;Outcome;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;Play;Polycomb;Population;Positioning Attribute;programs;Proteins;Receptor Signaling;Regulatory T-Lymphocyte;Rejuvenation;Reporter;Research;Resistance;response;Reticular Cell;Role;scaffold;senescence;single cell genomics;Solid;Stromal Cells;Stromal Change;T-Lymphocyte;targeted delivery;Testing;Time;TNFSF5 gene;trafficking;transcriptome;Transplant Recipients;Transplantation;Transplantation Tolerance;trend;Tumor Necrosis Factor-Beta;Waiting Lists

PROJECT_TITLE: Lymph node stromal senescence and transplant immunity


PHR: Public Health Relevance Statement Organ transplantation is the treatment of choice for end-stage-organ failure. Although aging affects immune compartments and functions in a complex and specific fashion, age-specific treatments have not been delineated. The goal of this proposal is to transform our understanding of age-specific alloimmunity and to improve the care for the rapidly increasing amount of older transplant recipients.

PROJECT_TERMS: Acceleration;Acute;adaptive immune response;adaptive immunity;Address;aerobic glycolysis;Affect;age related;age related changes;aged;Aging;Antigen-Presenting Cells;Antigens;Automobile Driving;B-Lymphocytes;Caring;CD28 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;cell age;Cell Aging;Cell Communication;Cells;Cellular Immunity;Cellular Metabolic Process;Chronic;Clinical;Complex;Data;design;Effectiveness;Elderly;end-stage organ failure;Exclusion;experience;Glutamate Metabolism Pathway;Glutamine;Goals;Graft Survival;human old age (65+);Immune;Immune response;Immunity;immunoregulation;immunosenescence;Immunosuppression;Immunosuppressive Agents;Impairment;improved;infection rate;Inflammaging;inhibitor;Innate Immune Response;innovation;isoimmunity;lymph nodes;Malignant Neoplasms;Mediating;Metabolic;Metabolic Pathway;Mitochondria;Mitochondrial DNA;Modification;multidisciplinary;Nanodelivery;nanoparticle delivery;Natural Immunity;new therapeutic target;novel;novel strategies;older patient;Older Population;Organ;Organ Transplantation;Outcome;Oxidative Phosphorylation;Pathogenicity;Play;Population;Positioning Attribute;Process;programs;Proliferating;public health relevance;Publishing;Regulation;Regulatory T-Lymphocyte;Research Personnel;Resistance;response;Role;senescent cell;senolytics;side effect;T-Lymphocyte;targeted delivery;Testing;Therapeutic;Time;Transplant Recipients;Transplantation;transplantation therapy;treatment choice

PROJECT_TITLE: Mechanisms and novel targets of T-cell Immunity in Aging


NIH_SPENDING_CATS: Aging;Bioengineering;Infectious Diseases;Kidney Disease;Nanotechnology;Organ Transplantation;Rare Diseases;Transplantation

PHR: The process of aging rewires the immune system and alters mechanisms of solid organ transplant rejection. Despite substantial increases in the frequency of aged patients undergoing transplantation, little is known how these processes work. The proposed studies will identify how unique settings of aging control transplant rejection, thereby facilitating the development of new therapeutics to treat rejection in aged individuals.

PI_NAMEs: SAGE, PETER THE (contact)

PROJECT_TERMS: Age;age related;age related changes;aged;Aging;aging mechanism;aging population;aging process;Anti-viral Response;Antibodies;Antibody Response;antibody-mediated rejection;antiviral immunity;B-Lymphocyte Epitopes;B-Lymphocytes;Cell Physiology;Cells;Clonal Evolution;CTLA4-Ig;Data;design;Development;dimensional analysis;Drug usage;Environment;Equilibrium;FOXP1 gene;Frequencies;Genetic Transcription;Goals;Graft Rejection;Heart Transplantation;Helper-Inducer T-Lymphocyte;high dimensionality;Human;human old age (65+);Hypersensitivity;Immune system;Immunity;Immunoglobulin Class Switching;Immunoglobulin Somatic Hypermutation;Immunoglobulin Switch Recombination;Immunosuppressive Agents;in vivo;Individual;Infection;Inflammaging;influenza infection;innovation;interleukin-21;Interleukin-6;isoimmunity;Kidney Transplantation;Knowledge;lymph nodes;Mediating;metabolomics;Modality;Mus;nanoparticle delivery;novel;novel therapeutics;old mice;Older Population;Opportunistic Infections;organ transplant rejection;Organ Transplantation;Outcome Study;Output;Pathogenicity;Patients;Physiological;Play;Population;post-transplant;pre-clinical;Predisposition;prevent;pro-aging;Process;Production;Publishing;Resistance;response;Role;senescence;Signal Transduction;Site;Solid;Specificity;System;Techniques;Testing;Therapeutic;therapeutic nanoparticles;tool;transcriptomics;Transplant Recipients;Transplantation;unpublished works;Work

PROJECT_TITLE: Antibody Mediated Rejection and Post-transplantation Anti-Viral Immunity in Aging


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Liver Cancer;Liver Disease;Pancreatic Cancer;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: SALT LAKE CITY

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE  Cancer typically takes years to go from one abnormal cell to a life-threatening tumor, but work in mouse models suggest that the kind of cell from which a tumor arises can have long-lasting effects on the behavior of the disease. In this study, we aim to develop methods to determine the so-called “cells of origin” of pancreatic and liver cancers, and determine if the clinical behavior of human cancers is also determined by features of those cells. We will use genetic information from human cancer samples to identify these cells and their relationship to tumor types and patient outcomes, with an ultimate goal of using these data as prognostic biomarkers in a clinical setting.

PI_NAMEs: MURTAUGH, LEWIS C (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Abnormal Cell;Acinar Cell;Address;Affect;analysis pipeline;Animal Model;B-Lymphocytes;Back;Behavior;Biological Markers;Biology;Body System;cancer cell;cancer genome;Cell Differentiation process;cell type;Cells;Clinic;Clinical;Data;deep sequencing;Detection;Development;Disease;driver mutation;Dryness;Duct (organ) structure;Ductal Epithelial Cell;Evolution;falls;Foundations;Future;Genes;genetic information;genetic manipulation;Genetic Transcription;genome sequencing;Genomic Data Commons;Genomics;Goals;Hepatocyte;Heterogeneity;Human;Huntsman Cancer Institute at the University of Utah;improved;Individual;innovation;insertion/deletion mutation;International;Investigation;Knowledge;Left;Lesion;Life;Liver;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of pancreas;Malignant Neoplasms;Methods;Molecular;mouse model;Mus;Mutation;mutational status;neoplastic cell;Normal Cell;Normal tissue morphology;novel marker;Outcome;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pancreatic Intraepithelial Neoplasia;patient stratification;Patient-Focused Outcomes;Patients;Phenotype;precursor cell;premalignant;Primary carcinoma of the liver cells;Process;Prognostic Marker;Property;prospective;Research;Route;Sampling;single-cell RNA sequencing;Somatic Mutation;Source;Specificity;stem cells;Study models;Tissues;tool;transcriptome sequencing;transcriptomics;treatment stratification;tumor;tumor initiation;Tumor Subtype;tumorigenesis;whole genome;Work

PROJECT_TITLE: Genomic lineage traces as biomarkers for human pancreatic and liver cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-F (J2)]


ORG_CITY: PORTLAND

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Differences in how liquid biopsy samples are handled and preserved before they are analyzed can significantly affect the accuracy of testing results. This project will systematically study the factors involved in preparing liquid blood and bone marrow aspirates in order to optimize the measurement accuracy and reproducibility of live cell, protein functional testing and the use of these tests in clinical precision medicine trials. This work will further accelerate the widespread adoption of next-generation functional testing leading to more accurate clinical decision-making and improve patient outcomes.

PI_NAMEs: TOGNON, CRISTINA E;VU, TOTHU Q (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, LOKESH

PROJECT_TERMS: Acceleration;Acute Myelocytic Leukemia;Adoption;Advanced Malignant Neoplasm;Affect;Area;Benchmarking;Biological Assay;Biological Markers;Biopsy Specimen;Blood;Bone Marrow;Bone Marrow Aspiration;Bone marrow biopsy;cancer diagnosis;Cell Physiology;Cell Survival;Cells;cellular imaging;Cessation of life;Clinical;clinical decision-making;clinical implementation;clinical research site;clinical translation;Clinical Trials;clinically relevant;Collaborations;Collection;Cryopreservation;Data;data quality;Data Set;Development;drug development;drug sensitivity;Early Diagnosis;Effectiveness;Evaluation;Exhibits;Feedback;Flow Cytometry;Freezing;functional genomics;genomic data;Goals;Guidelines;Hospitals;Image;imaging platform;Immunooncology;Impact evaluation;improved;Industry;Institution;knowledge base;leukemia;liquid biopsy;Liquid substance;Malignant Neoplasms;Mass Spectrum Analysis;Measurable;Measurement;Measures;Methods;Molecular Genetics;next generation;novel;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;peripheral blood;personalized medicine;Pharmaceutical Preparations;Phase;Phenotype;Practice Guidelines;precision medicine;precision medicine clinical trials;Precision medicine trial;precision oncology;preservation;Private Sector;Process;Protein Array;Proteins;Quality Control;Reporting;Reproducibility;Research;research clinical testing;Research Personnel;Residual Neoplasm;Retrieval;Retrospective Studies;sample collection;Sampling;Scientist;Signal Pathway;Signal Transduction;Signaling Protein;Site;Specimen;Standardization;success;Techniques;Temperature;Test Result;Testing;Therapeutic;therapeutic development;Time;Translating;Validation;Variant;Work;World Health Organization

PROJECT_TITLE: Guidelines for processing and storing liquid biopsy samples for functional assays in research and clinical testing.

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-D (J1)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Warfarin (Coumadin™ and others) is a blood thinner that prevents venous and arterial blood clots but doubles the risk of bleeding. To reduce the risks of warfarin overdose and bleeding, the investigators will use personalized medicine and machine learning to develop algorithms to guide the initiation of warfarin therapy. They will put these algorithms on a free, non-profit website (WarfarinDosing.org) and integrate them into electronic medical records.

PI_NAMEs: GAGE, BRIAN F (contact)

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: Algorithms;American;Anticoagulant therapy;Anticoagulants;Attention;Blood coagulation;Clinical;clinical decision support;Clinical Trials;Coagulation Process;Code;Computerized Medical Record;Data;deep learning algorithm;Dependence;Dose;Effectiveness;Electronic Health Record;electronic health record system;Emergency department visit;Equilibrium;Genetic;Goals;Graph;Hemorrhage;Iatrogenesis;improved;innovation;International Classification of Diseases;International Normalized Ratio;Intervention;Laboratories;Learning;Linear Models;Linear Regressions;Machine Learning;machine learning algorithm;machine learning model;Medical center;Modeling;novel;Outcome;Overdose;overdose risk;Participant;Patients;personalized medicine;Pharmaceutical Preparations;Pharmacogenetics;predictive modeling;prevent;primary outcome;randomized, clinical trials;Research;Research Personnel;response;Risk;Risk Reduction;Safety;Sampling;success;supervised learning;System;Testing;Therapeutic;thrombotic;Training;Update;Venous;Waran;Warfarin;web app;web site

PROJECT_TITLE: Pharmacogenetic Refinement of the Warfarin Dose Using Machine Learning

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative The proposed research is relevant to public health because the development and validation of crucial new technologies for selective control of synaptically-connected circuit elements across the brain during behavior is essential for defining novel brain circuits and therapeutic strategies for treating devastating psychiatric disorders, such as depression, anxiety disorders, and schizophrenia, as well as neurological disorders including memory decline, stroke, and epilepsy, which currently have a profound negative impact on public health. The proposed research is relevant to NIH’s mission in that it directly addresses the call for innovating and validating novel tools to facilitate the detailed analysis of complex circuits and to enable the immense potential of circuit manipulation (BRAIN Initiative).

PI_NAMEs: CHEN, XIAOKE ;SOLTESZ, IVAN ;TING, ALICE Y (contact)

PROGRAM_OFFICER_NAME: KIM, EUNYOUNG

PROJECT_TERMS: Acute;addiction;Address;Anatomy;Antigens;Anxiety Disorders;Assessment tool;Behavior;Behavioral;Behavioral Assay;behavioral sensitization;Binding;Biological;Biology;Brain;BRAIN initiative;Brain region;Calcium;Cell membrane;cell type;Cells;Chemicals;Chimeric Proteins;Cocaine;Communities;Complex;Data;design;designer receptors exclusively activated by designer drugs;Development;Directed Molecular Evolution;Dopamine;Electrophysiology (science);Elements;Engineering;Ensure;Enzymes;Epilepsy;experience;experimental study;Feedback;Fluorescence;Gene Expression;Genetic;GTP-Binding Proteins;Hippocampus;Hour;Image;in vivo;in vivo imaging;innovation;Ion Channel;Label;Light;Location;Membrane Potentials;Memory;Memory Loss;Mental Depression;Mental disorders;Mission;Modernization;Molecular;motivated behavior;Mus;Nervous System Disorder;neural;Neurons;Neurosciences;Neurosciences Research;neurotransmitter release;new technology;novel;Nucleus Accumbens;opioid withdrawal;Opsin;optogenetics;Pain;Pathologic;Pathway interactions;Pattern;Pharmaceutical Preparations;Physiology;Population;postsynaptic;postsynaptic neurons;Prefrontal Cortex;presynaptic;Protein Engineering;Public Health;Receptor Signaling;Research;Role;Schizophrenia;Scientist;screening;Sensitivity and Specificity;Site;Slice;Specificity;Stroke;Surface;Surface Antigens;Synapses;Synaptic Receptors;Synaptic Vesicles;synergism;System;Technology;technology platform;Testing;tetanospasmin;Tetanus Toxin;Thalamic structure;Therapeutic;tool;Tumor Markers;two-photon;United States National Institutes of Health;Validation

PROJECT_TITLE: Molecular tools for precise manipulation of defined synaptic connections

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-M (01)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: PORTLAND VA MEDICAL CENTER

PHR: Lung Cancer Screening (LCS) has been recommended by the United States Preventive Services Task Force and Veterans Health Administration (VA) since 2013 and 2017, respectively. However, most of the estimated 1.5 to 2.7 million eligible Veterans have not participated in LCS. VA has mandated that facilities must include high-quality components in their screening program or refer eligible Veterans to community care. Many patients who received LCS have had inadequate care coordination, may have little knowledge about the benefits and harms and may not have had their values and preferences assessed. These obstacles may lead to fragmented care, poor adherence, and personal regret about patients’ decision to participate in screening. Thus, it is important to understand processes for community care LCS and identify methods that VA can use to improve that care.

PI_NAMEs: SLATORE, CHRISTOPHER G. (contact)

PROJECT_TERMS: Adherence;adherence rate;Affect;Attitude;care coordination;care fragmentation;Caring;Characteristics;Communication;Communities;Community Healthcare;Cross-Sectional Studies;Data;data warehouse;Decision Making;dynamic system;Electronic Health Record;Eligibility Determination;Enrollment;Ensure;follow-up;Future;Guidelines;Health care facility;health care settings;Healthcare;improved;improved outcome;Information Systems;innovation;instrument;Interview;Knowledge;Link;low dose computed tomography;lung cancer screening;Lung CAT Scan;Malignant neoplasm of lung;Manuscripts;Measures;Methodology;Methods;Modeling;mortality;Outcome;Patient Self-Report;patient-clinician communication;Patient-Focused Outcomes;Patients;preference;Procedures;Process;programs;Qualitative Methods;Quality of Care;Radiology Specialty;Recommendation;Records;Regrets;Reporting;Resources;Respondent;rural area;rural setting;satisfaction;screening;screening program;smoking cessation;Surveys;Techniques;Theoretical model;Thinking;United States Preventative Services Task Force;uptake;Veterans;Veterans Health Administration;Visualization

PROJECT_TITLE: Lung Cancer Screening for Veterans Enrolled in Community Care: Modifiable Mechanisms to Improve Patient-Centered Outcomes

STUDY_SECTION_NAME: HSR-5 Health Care System Organization and Delivery and Women's Health[HSR5]


ORG_CITY: GALVESTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: PROJECT NARRATIVE - Overall Select zoonotic RNA viruses within the Paramyxoviridae and Bunyavirales represent a continuous threat to global public health due to their ease of dissemination and/or transmissibility from person-to-person and result in significant morbidity and mortality, thus requiring special actions for public health preparedness. These viral threats to global public health are heightened due to the absence of approved vaccines or therapeutics. There is a clear unmet need for vaccines and antibody-based therapeutics to address these threats that can arise from natural outbreaks, epidemics, or bio-weaponization and deliberate release.

PI_NAMEs: BRODER, CHRISTOPHER C;GEISBERT, THOMAS WILLIAM (contact)

PROGRAM_OFFICER_NAME: BRIDWELL, ANNE ELIZABETH MAYER

PROJECT_TERMS: Address;Adjuvant;Animal Model;animal model development;Animal Testing;Animals;Antibodies;Antibody Therapy;Antigens;Arenavirus;Australia;biothreat;Bolivian Hemorrhagic Fever Virus;Bunyavirales;Category A pathogen;Cells;Chapare Virus;Collaborations;Communicable Diseases;Containment;Credentialing;Crimean-Congo Hemorrhagic Fever Virus;Data;data management;Data Management Resources;Disease;Disease Outbreaks;drug development;Ensure;Epidemic;experience;Family;Far East;Fostering;Goals;Hemorrhage;Hendra;Hendra Virus;Henipavirus;Human;human monoclonal antibodies;human pathogen;Immunology;in vivo;industry partner;Langya;Lassa;Lassa virus;Learning;Livestock;Lujo virus;Monoclonal Antibodies;Morbidity - disease rate;mortality;Nairovirus;nanobodies;National Institute of Allergy and Infectious Disease;Needles;Nervous System Disorder;Nipah;Nipah Virus;novel;pandemic potential;pandemic preparedness;Paramyxovirus;Pathogenesis;pathogenic virus;Pathogenicity;Persons;Phage Display;Phase;Play;preclinical evaluation;priority pathogen;Procedures;Process;prototype;Public Health;Readiness;Recombinants;Research;Research Project Grants;Research Support;Respiratory Disease;reverse genetics;RNA Viruses;Science;Southeastern Asia;structural biology;Subunit Vaccines;Survivors;System;Testing;Therapeutic;therapeutic evaluation;tool;Transgenic Mice;Transgenic Organisms;Translating;translational research program;Tropism;Vaccination;vaccine evaluation;vaccine platform;vaccine-induced antibodies;Vaccines;Viral;Viral Antigens;virology;Virus;Virus Diseases;volunteer;weapons;World Health Organization;Zoonoses

PROJECT_TITLE: Paramyxoviridae and Bunyavirales Vaccines and Antibodies Center (PABVAX)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 FDS-M (J1)]


PI_NAMEs: GEISBERT, THOMAS WILLIAM (contact)

PROJECT_TERMS: Administrator;Antibodies;Bunyavirales;Collaborations;Communication;Core Facility;data sharing;Decision Making;Development;Ensure;Evaluation Research;Goals;Human Resources;human subject;Infection;Information Dissemination;Institution;Lead;Medical;meetings;member;Mission;Monoclonal Antibodies;National Institute of Allergy and Infectious Disease;operation;pandemic preparedness;Paramyxovirus;Participant;Policies;Process;product development;Productivity;programs;prototype;Records;Reporting;Research;Research Activity;research and development;Research Personnel;Research Project Grants;Resources;responsible research conduct;Scientist;Structure;synergism;Teleconferences;Texas;Translational Research;United States National Institutes of Health;Universities;vaccine development;vaccine-induced antibodies;Vaccines;Vertebrates;Videoconferencing;Virus;Writing

PROJECT_TITLE: Core A: Administrative Core


PI_NAMEs: GOLOVKO, GEORGE  (contact)

PROJECT_TERMS: Adherence;Agreement;Antibodies;Bioinformatics;Bunyavirales;Clinical;Clinical Data;Collaborations;Collection;Communication;Contractor;dashboard;Data;data access;Data Analyses;Data Collection;data dictionary;data dissemination;Data Engineering;data exchange;data format;data integrity;data management;Data Management Resources;data mining;data platform;data quality;data quality/integrity;Data Science;Data Scientist;Data Security;Data Set;data sharing;data sharing networks;data standards;Data Storage and Retrieval;Decision Making;design;Development;Dimensions;Disclosure;Documentation;Educational process of instructing;Educational workshop;encryption;Ensure;Environment;experience;Experimental Designs;FAIR principles;Goals;Guidelines;Health Insurance Portability and Accountability Act;health record;indexing;Individual;Industrialization;Infrastructure;interoperability;Intuition;Investigation;Knowledge;Life Cycle Stages;Measures;Metadata;Mission;Monitor;multiple omics;Nuclear Power Plants;Outcome Study;Paramyxovirus;petabyte;Policies;preservation;Privatization;Procedures;Process;product development;public repository;Publishing;quality assurance;Quality Control;Regulation;Replication-Associated Process;Reproducibility;Research;Research Design;Research Project Grants;Risk Assessment;Role;Secure;Security;Source;Standardization;Statistical Data Interpretation;System;Time;tool;Training;United States National Institutes of Health;user-friendly;Vaccines;Validation

PROJECT_TITLE: Core B: Data Management


PI_NAMEs: FALO, LOUIS D (contact)

PROJECT_TERMS: Achievement;Adjuvant;Antibodies;Antigen Presentation;antigen-specific T cells;Antigens;Arenavirus;Binding;Biological Assay;Bolivian Hemorrhagic Fever Virus;Bunyavirales;Chapare Virus;Clinical;clinical development;clinical translation;Clinical Trials;Complement;Complex;cost effectiveness;Crimean Hemorrhagic Fever;Cutaneous;Data;Development;draining lymph node;Emerging Communicable Diseases;emerging virus;Equity;Evaluation;experience;Family;Formulation;Friends;Generations;Glycoproteins;Goals;Health Personnel;health training;Hendra;Human;IgG1;IgG2;Immune;Immune response;Immunity;Immunization;Immunize;immunogenicity;Immunoglobulin A;Immunoglobulin G;Immunoglobulin M;Immunologic Adjuvants;Immunologic Stimulation;Immunologics;improved;In Vitro;innovation;Intramuscular;Langya;Lassa virus;Lujo virus;macromolecule;Mass Vaccinations;Mus;Nairovirus;nanoassembly;Needles;next generation;Nipah;novel;pandemic preparedness;Paramyxovirus;pathogen;pathogenic virus;Patients;Pharmaceutical Preparations;Play;polyphosphazene;priority pathogen;Procedures;Production;Property;Protocols documentation;prototype;Quality Control;rational design;Recombinants;Reproducibility;Research;Research Project Grants;Research Support;Route;Self Administration;Serum;Skin;Spleen;subcutaneous;Syringes;T cell response;Technology;thermostability;uptake;Vaccination;vaccination strategy;vaccine delivery;vaccine evaluation;vaccine platform;vaccine-induced immunity;Vaccines;Validation;Viral;Viral Antigens;Virus;Work

PROJECT_TITLE: Core C: Microneedle Patch Vaccines


PI_NAMEs: ZEITLIN, LARRY  (contact)

PROJECT_TERMS: Animal Model;Antibodies;Arenavirus;Biological Products;Bolivian Hemorrhagic Fever Virus;Bunyavirales;Chapare Virus;data management;Development;Dose;Emergency Situation;Engineering;Epitopes;expectation;experience;Family;Goals;Half-Life;Hendra;Immunity;Immunocompromised Host;Industrialization;Intervention;Intramuscular;Intravenous;Langya;Lassa;Lead;lead optimization;Link;Lujo virus;manufacturability;manufacture;manufacturing run;Monoclonal Antibodies;Mutation;Nairovirus;nanobodies;Needles;Nipah;Paramyxovirus;Performance;Play;Polysaccharides;Population;pre-clinical;Process;Production;Prophylactic treatment;prototype;Research Project Grants;Scientist;stability testing;Subunit Vaccines;synergism;Testing;Time;Translational Research;Vaccination;Vaccine Antigen;Vaccine Research;vaccine-induced antibodies;Vaccines;Work

PROJECT_TITLE: Core D: Early and IND-Enabling Translational Research for Vaccines and MAbs


PROJECT_TERMS: Address;animal efficacy;Animal Husbandry;Animal Model;animal model development;animal tissue;Animals;Antibodies;Arenavirus;Autopsy;Biological Assay;biosafety level 4 facility;Blood specimen;Bolivian Hemorrhagic Fever Virus;Bunyavirales;Case Fatality Rates;Chapare Virus;Clinical;Clinical Chemistry;Clinical Pathology;Collaborations;Containment;Crimean-Congo Hemorrhagic Fever Virus;Data;data management;design;Development;Disease;Disease Outbreaks;efficacy study;Endotoxins;Epidemic;Equipment;experience;Family;Fostering;Generations;Genomics;Hematology;Hemorrhage;Hendra Virus;Henipavirus;Housing;Human;human disease;Human Resources;IACUC;Immune;Immunologics;Immunology;In Vitro;in vitro Assay;Infection;Laboratories;Langya;Lassa;Laws;Lujo virus;Modeling;Monitor;multiplex assay;Mycoplasma;Nairovirus;Nipah Virus;novel vaccines;pandemic preparedness;Paramyxovirus;pathogen;Pathologic;Pathology;Periodicals;Persons;Plaque Assay;preclinical evaluation;priority pathogen;Protocols documentation;Public Health;Reagent;recombinant virus;Recombinants;Recording of previous events;Records;repository;Research Personnel;Research Project Grants;Resources;reverse genetics;Reverse Transcriptase Polymerase Chain Reaction;RNA Viruses;sample collection;Sampling;Secure;Services;sterility testing;System;Technical Expertise;Testing;Therapeutic;Tissue Sample;Tissues;tool;Training;transcriptomics;translational research program;transmission process;Vaccination;vaccine evaluation;Vaccines;Variant;Viral;Viral Load result;Viral Physiology;virology;Virus;World Health Organization;Zoonoses

PROJECT_TITLE: Core E: Animal Model Development and Preclinical Evaluation


PI_NAMEs: CROSS, ROBERT W (contact)

PROJECT_TERMS: Address;Adjuvant;Animal Model;Animals;Antibodies;Antibody Therapy;Antigens;Arenavirus;Biological Products;Bolivian Hemorrhagic Fever Virus;Bunyavirales;Bunyaviridae;Category A pathogen;Cavia;Chapare Virus;Containment;Coupled;COVID-19;Crimean-Congo Hemorrhagic Fever Virus;Cutaneous;Data;Death Rate;design;Development;Disease;Drug Kinetics;Ebola Hemorrhagic Fever;Engineering;Epidemic;Family;Generations;Genetic;Glycoproteins;Goals;Half-Life;Hemorrhage;Human;human pathogen;Humoral Immunities;Immune;Immunity;Immunology;Improve Access;International;Junin virus;Knockout Mice;Lassa;Life Extension;long-term sequelae;Lujo virus;member;Monoclonal Antibodies;Monoclonal Antibody Therapy;Morbidity - disease rate;mortality;Nairovirus;National Institute of Allergy and Infectious Disease;Natural Immunity;Needles;nonhuman primate;novel;Nucleoproteins;Paramyxovirus;pathogen;Persons;Play;Point Mutation;pre-exposure prophylaxis;priority pathogen;product development;Production;prophylactic;Prophylactic treatment;protective efficacy;Proteins;prototype;Public Health;Readiness;Recombinant Proteins;recombinant virus;Recombinants;Research;Research Project Grants;reverse genetics;Rodent;Role;Subunit Vaccines;success;Surface;Survivors;System;Tacaribe Complex Viruses;Testing;Therapeutic;tick-borne;tool;transmission process;treatment strategy;Vaccination;vaccine development;vaccine evaluation;Vaccines;Venezuelan hemorrhagic fever virus;Viral;virology;Virus;Virus Diseases;weapons;Work;World Health Organization

PROJECT_TITLE: RP1: Antigen design and testing of arenavirus and nairovirus


PI_NAMEs: BRODER, CHRISTOPHER C (contact)

PROJECT_TERMS: Adjuvant;Animal Model;Antibodies;Antigens;Australia;Bangladesh;bat-borne;Biological Assay;biothreat;Bunyavirales;Cells;Collaborations;combat;Communicable Diseases;Data;Development;Disease;Ephrin-B2;Ephrins;Evaluation;experimental study;Far East;Ferrets;Fostering;Future;glycoprotein G;Glycoproteins;Hendra Virus;Henipavirus;Human;Immune response;Immune Sera;immunogenicity;in vivo;Infection;innovation;Langya;Licensing;Ligands;Livestock;Malaysia;Mammals;Membrane Glycoproteins;Modeling;Monoclonal Antibodies;Mus;nanobodies;Nature;Needles;Nervous System Disorder;neutralizing antibody;Nipah Virus;nonhuman primate;novel;novel strategies;pandemic potential;pandemic preparedness;Paramyxovirus;Pathogenicity;Phase;Play;polyphosphazene;priority pathogen;prototype;Public Health;rapid test;receptor;Recombinants;Reporter;Reporter Genes;Research Project Grants;Respiratory Disease;response;reverse genetics;RNA Viruses;Rodent;Skin;Subunit Vaccines;System;Testing;thermostability;tool;Translating;Tropism;Vaccination;vaccination strategy;Vaccine Antigen;vaccine evaluation;vaccine immunogenicity;vaccine platform;vaccine response;Vaccines;Vesicular stomatitis Indiana virus;Viral;Viral Antibodies;Virus;Virus Diseases;Zoonoses

PROJECT_TITLE: RP2: Vaccines and antibodies to henipavirus


PI_NAMEs: SCHAEFER, BRIAN  (contact)

PROJECT_TERMS: Address;Anatomy;Animal Model;Animals;Antibodies;Antibody Response;Antibody Therapy;Area;Australia;biocontainment facility;Biology;Bioluminescence;biothreat;Brain;brain parenchyma;brain tissue;Breeding;Bunyavirales;Central Nervous System Infections;Cessation of life;Chimera organism;Collaborations;Containment;Data;Development;Disease;Disease Outbreaks;emerging virus;Encephalitis;Ephrin-B3;Family;Fatality rate;Flow Cytometry;Future;Gene Expression;Glycoproteins;Hendra Virus;Henipavirus;Henipavirus Infections;Histologic;Histology;Human;human pathogen;Immunodeficient Mouse;in vivo;India;Individual;Infection;Innate Immune Response;Interferons;Invaded;Investigation;Kinetics;Livestock;Luciferases;Methodology;Modeling;Monoclonal Antibodies;mortality;mouse model;Mouse Strains;Mus;nanobodies;Nervous System Disorder;Neurologic Dysfunctions;Neuropathogenesis;Neurotropism;neurovirulence;Nipah Virus;novel therapeutics;Paramyxovirus;pathogen;Pathogenesis;pathogenic virus;Pathogenicity;Pathologic;Phenotype;pre-clinical;pre-clinical research;preclinical study;programs;receptor binding;Recombinants;Recording of previous events;Research;Research Project Grants;respiratory;response;RNA Viruses;Role;Southeastern Asia;STAT1 gene;System;Testing;Therapeutic;Therapeutic Effect;Therapeutic Monoclonal Antibodies;Tissue Model;transcriptomics;Translational Research;transmission process;Treatment Efficacy;Vaccines;Validation;Viral;Viral Genome;Virus;Virus Diseases;Work

PROJECT_TITLE: RP3: Cedar henipavirus animal model


PI_NAMEs: CROWE, JAMES E (contact)

PROJECT_TERMS: Active Immunization;Animal Model;Animals;Antibodies;Antibody Repertoire;Antigens;Arenavirus;B-Lymphocytes;Binding;Biological Products;Bolivian Hemorrhagic Fever Virus;Bunyavirales;Cavia;Cell Line;Cell Separation;Chapare Virus;Chimeric Proteins;Chinese Hamster Ovary Cell;Collection;Combined Modality Therapy;Complex;Crimean Hemorrhagic Fever;Crimean-Congo Hemorrhagic Fever Virus;Cyclic GMP;design;Development;Dose;electron crystallography;Electron Microscopy;Engineering;Epidemic;Epitope Mapping;Epitopes;Evaluation;Family;Future;future epidemic;Gene Modified;Goals;GTP-Binding Proteins;Half-Life;Hamsters;Hendra;Hendra Virus;Henipavirus;high throughput screening;Human;human monoclonal antibodies;humanized mouse;Hybridomas;Immune;Immunity;Immunize;improved;In Vitro;in vivo;Individual;Industrialization;Infection;Injections;Langya;Lassa;Lassa virus;Lead;Lujo virus;manufacture;Mediating;medical countermeasure;Membrane Proteins;Methods;Modeling;Monoclonal Antibodies;Mus;Nairovirus;neutralizing antibody;neutralizing monoclonal antibodies;Nipah;Nipah Virus;nonhuman primate;Pan Genus;Paramyxovirus;Passive Immunization;pathogen;Play;Preparation;prevent;Production;programs;Property;protective efficacy;prototype;Recombinants;Resistance;single-cell RNA sequencing;Site;structural biology;synergism;Techniques;Testing;therapeutic evaluation;Transgenic Mice;Treatment Efficacy;Vaccine Antigen;Vaccines;Viral;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: RP4: Monoclonal antibodies against henipaviruses, arenaviruses, and nairoviruses


PI_NAMEs: XU, JIANLIANG ;XU, KAI  (contact)

PROJECT_TERMS: Address;Advanced Development;Affect;Africa;Animal Model;Animals;Anti-viral Therapy;Antibodies;antigen binding;Antigens;Arenavirus;Arenavirus Infections;Biological Availability;blood-brain barrier crossing;blood-brain barrier penetration;Bolivian Hemorrhagic Fever;Bolivian Hemorrhagic Fever Virus;Bunyavirales;Central Nervous System;Central Nervous System Diseases;Characteristics;Chimera organism;Clinical;combat;comparative efficacy;Complex;COVID-19 pandemic;cross reactivity;Death Rate;design;Development;drug development;effective therapy;Electron Microscopy;emerging pathogen;emerging virus;Engineering;Ensure;Epitopes;Exhibits;Future;global health;glycoprotein G;Glycoproteins;glycosylation;Goals;Hendra Virus;Henipavirus;Henipavirus Infections;Human;Immunization;immunogenic;improved;innovation;insight;interest;Knowledge;Lassa Fever;Lassa virus;Libraries;Licensing;member;Membrane Glycoproteins;Molecular Conformation;mouse model;nanobodies;nanoengineering;nanosized;Nipah Virus;novel;Paramyxovirus;particle;pathogen;pathogenic virus;Penetration;Phase;Polysaccharides;prototype;Public Health;rational design;Research;respiratory;Risk;Specificity;Structure;Tacaribe Complex Viruses;targeted treatment;Techniques;TFRC gene;Therapeutic;Therapeutic Intervention;Tissues;Treatment Efficacy;Vaccines;Viral;Viral Hemorrhagic Fevers;Virus;Virus Diseases;X-Ray Crystallography

PROJECT_TITLE: RP5: Nanobody therapeutics against henipaviruses, arenaviruses, and structural characterization


ADMINISTERING_IC: OH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: BOWLING GREEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WESTERN KENTUCKY UNIVERSITY

ORG_STATE: KY

PHR: Public Health Relevance Statement  To meet the public health needs of our regional communities, the EOHS programs, Bachelor of Science and Master of Science, prepare students with a foundation in basic and applied sciences, including biology, chemistry, mathematics, physics, geology, and public health. The interdisciplinary application of training in the EOHS programs has led to the development of skills that trainees utilize in a variety of public health settings. Students graduating from the EOHS programs regularly pursue advanced degrees, and have become occupational safety and health specialists, environmental health and safety specialists, industrial hygienists, or work in closely related fields with emphases on human health protection and advancement in diverse worksites and in underserved communities across Kentucky, and beyond.

PI_NAMEs: TAYLOR, RITCHIE DON (contact)

PROJECT_TITLE: The Environmental and Occupational Health Science Program at Western Kentucky University


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: AMHERST

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: Project Narrative This application proposes a continuation of our occupational safety and health (OSH) training program that focuses on strengthening the pool of qualified OSH professionals in New York and the surrounding region. The program aims to meet industry needs by providing multidisciplinary training that includes coursework and practical experience to develop technical skills in safety, industrial hygiene, and ergonomics, along with professional skills in management, effective communication, and regulatory affairs.

PI_NAMEs: CAVUOTO, LORA ANNE (contact)

PROJECT_TITLE: University at Buffalo, SUNY Occupational Safety and Health Training Project


ORG_CITY: WEST LAFAYETTE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: NARRATIVE This project supports research and training of undergraduate and graduate students to become leaders in industrial hygiene and occupational safety. Through training and research, this program directly supports the CDC’s Healthy People 2030 goals of reducing work-related fatalities, injuries, and disease as well as multiple goals within NIOSH’s National Occupational Research Agenda, including: Construction, Manufacturing, and Mining Sectors as well as Cross-Sector Goals within Cancer, Reproductive, Cardiovascular, and Other Chronic Disease Prevention and Respiratory Health. In particular, this program addresses the need for increased numbers of highly skilled occupational health and safety professionals in the Midwest, a region with a substantial amount of industry yet, unfortunately, higher than average rates of workplace fatalities and injuries.

PI_NAMEs: WELLS, ELLEN M (contact)

PROJECT_TITLE: Occupational Safety and Health Training Grant


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Stroke;Traumatic Head and Spine Injury;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Both comparative and single-race studies suggest that Alzheimer’s Disease and related dementias (ADRD) are becoming as prevalent among American Indians and Alaska Natives (AI/ANs) as they are in the all-races population with the reduction in life expectancy disparities experienced by AI/ANs. However, most of the small amount of work in this area was conducted in rural or reservation settings, even though over 70% of AI/ANs reside in urban areas. This study will address the epidemiology of ADRD in urban AI/AN elders aged 55 and older, and examine how mechanisms related to vascular brain injury may contribute to ADRD pathology with advanced imaging techniques and neurocognitive assessments, establishing a baseline cohort of urban elders for future longitudinal study.

PI_NAMEs: NELSON, LONNIE A. (contact)

PROGRAM_OFFICER_NAME: PERCY-LAURRY, ANTOINETTE LOIS

PROJECT_TERMS: Acute;Adult;Age;Age-associated memory impairment;aged;Alaska Native;Alaska Native population;Alcohol consumption;Alleles;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American Indian Population;American Indians;Area;Behavioral;Biological Markers;Brain imaging;brain magnetic resonance imaging;Caring;cerebral atrophy;Cerebrovascular Disorders;Cerebrovascular Trauma;Cities;Clinical;clinical risk;Cognitive;cognitive function;cohort;Cohort Studies;Communities;comparative;Cross-Sectional Studies;Data;Data Collection;Databases;Development;Diabetes Mellitus;Disease;Disparity;Education;Educational Status;Elderly;Epidemiology;Evaluation;Exclusion;experience;Foundations;Funding;Future;Genetic;Genetic Risk;genetic testing;Geographic Locations;Geography;Health;health care availability;High Prevalence;higher education;Hypertension;Image;Imaging Techniques;Impaired cognition;Influentials;innovation;Intervention;Kidney Diseases;Life Expectancy;Life Style;lifestyle factors;Longitudinal cohort study;Longitudinal Studies;Low Prevalence;low socioeconomic status;Magnetic Resonance Imaging;Measures;Mediation;Mediator;medical specialties;men;metropolitan;Motor;National Institute on Aging;native elder;Neurocognitive;neuroimaging;Neuropsychology;Non-Insulin-Dependent Diabetes Mellitus;novel;Oklahoma;Participant;Pathology;performance tests;Physical Function;Pilot Projects;Population;pre-clinical;Preparation;Prevalence;prevent;Probability;Prospective, cohort study;protective effect;protective factors;Protocols documentation;Psyche structure;Public Health;Publications;Race;racial population;recruit;Reporting;Research;Research Personnel;Reservations;Resources;Risk;Risk Factors;risk selection;Rural;rural Americans;rural area;Sampling;Seminal;sex;Source;Stroke;Testing;Transient Ischemic Attack;Traumatic Brain Injury;Tribes;urban area;Urban Health;urban Native American;urban setting;White Matter Hyperintensity;Woman;Work

PROJECT_TITLE: URBAn Native Elders (URBANE): Risk and Protective Factors for Alzheimer's and Related Dementias

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-Z(55)]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Cannabinoid Research;Chronic Pain;Complementary and Integrative Health;Dietary Supplements;Natural Products;Neurosciences;Pain Research;Therapeutic Cannabinoid Research

ORG_CITY: SYRACUSE

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: PROJECT NARRATIVE Throughout recorded history, humans have used natural products, including the cannabis plant (Cannabis sativa/indica), for medicinal purposes. However, like other natural products, cannabis is not a single chemical entity, but rather contains over 100 phytocannabinoids as well as over 500 other identified chemicals, including the terpenoids that give cannabis its distinctive flavoring and aroma. Recently, we have secured access to purified minor cannabinoids synthesized via a patented biosynthetic process in quantities that allow for preclinical in vivo testing. The goal of the proposed project is to provide a comprehensive evaluation of these compounds alone, and in planned combinations, to determine their potential efficacy as analgesics. In addition, we will conduct a parallel investigation of selected terpenes that have been identified in the cannabis plant. Discovery of non-opioid analgesics could have a major impact on reducing opioid-associated morbidity and mortality.

PI_NAMEs: GAMAGE, THOMAS F (contact)

PROGRAM_OFFICER_NAME: BELFER, INNA

PROJECT_TERMS: Absence of pain sensation;abuse liability;Acetic Acids;Acids;Acute Pain;Adverse effects;Analgesics;Animal Model;antinociception;Aspirin;Behavior;Biological Assay;Breeding;Calcium Channel;Cannabidiol;cannabimimetics;Cannabinoids;Cannabis;Cannabis sativa plant;Capsaicin;Catalepsy;Characteristics;Chemicals;Chili Pepper;CNR1 gene;CNR2 gene;combat;cytokine;Dependence;Development;Dose;drug development;drug discrimination;efficacy evaluation;Enzyme-Linked Immunosorbent Assay;Evaluation;experimental study;Flavoring;Goals;GTP-Binding Proteins;Human;in vivo evaluation;Individual;Inflammation;inflammatory pain;Injections;Investigation;Legal patent;Ligation;Mediating;Mediation;Medicine;Metabolic Pathway;Metabolism;Methods;Minor;Modeling;Modernization;Morbidity - disease rate;mortality;Motor Activity;mouse model;mu opioid receptors;Mus;natural hypothermia;Natural Products;Natural Remedy;non-opioid analgesic;novel;Opioid;Opium;Orphan;Pain;pain behavior;Pain Measurement;pain patient;pain perception;pain relief;pain sensation;painful neuropathy;Papaver;Peripheral;Pharmaceutical Preparations;Pharmacologic Substance;phytocannabinoid;Plants;pre-clinical;preclinical evaluation;Procedures;Process;Property;receptor;Receptor Activation;receptor binding;Recording of previous events;Recreation;Rodent;sciatic nerve;screening;Secure;Signal Transduction;Stretching;Tail;Terpenes;Testing;Tetrahydrocannabinol;Therapeutic Effect;Therapeutic Uses;Treatment Efficacy;Trees;TRP channel;urinary;Urine;Visceral pain;Willow

PROJECT_TITLE: Minor Cannabinoids and Terpenes: Preclinical Evaluation as Analgesics


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: RELEVANCE TO PUBLIC HEALTH Inflammatory bowel diseases are characterized by altered gut microbial short-chain fatty acids (SCFAs), upregulated interleukin-22 (IL-22) activity, and impaired intestinal stem cell (ISC) self-renewal and differentiation. The SCFA, butyrate, enhances IL-22 receptor expression and signaling in human colon cancer cells, and IL-22 is theorized to favor asymmetric division of ISCs into progenitor cells during intestinal wound healing, but robust in vitro methods to study this mechanism have yet to be established. This proposal seeks to investigate butyrate effects on IL-22-induced asymmetric division of primary human colonic ISCs using a novel planar crypt microarray (PCM) platform and reporter cell lines for live-imaging and transcriptomic analysis, shedding light on the potential role of butyrate-IL-22-signaling in IBD pathogenesis.

PI_NAMEs: OK, MERYEM TYRRASCH (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: 3-Dimensional;Adult;Affect;Apical;Bioinformatics;Butyrates;cancer cell;Cancer cell line;career development;Cell Culture Techniques;Cell Differentiation process;Cell division;Cell Line;Cell Lineage;Cell Maintenance;Cell Nucleus;Cells;Cellular biology;Chimeric Proteins;Clinical Skills;Clustered Regularly Interspaced Short Palindromic Repeats;Colon;Colon Carcinoma;Complex;CRISPR/Cas technology;Crohn's disease;Data;Development;Devices;dysbiosis;Environment;Epithelial Cells;Epithelium;epithelium regeneration;Evaluation;experimental study;Exposure to;fabrication;Fluorescence;Foundations;Functional disorder;Gene Expression;Genes;Genetic;Genomics;Goals;Goblet Cells;Growth Factor;Human;human model;Hybrids;Image;Immune response;Immunofluorescence Immunologic;Impairment;improved;In Vitro;Inflammatory Bowel Diseases;insertion/deletion mutation;interleukin-22;intestinal epithelium;Intestines;Knock-out;Label;Learning;Light;live cell imaging;loss of function;loss of function mutation;Mammalian Cell;Membrane;Methods;microbial;microdevice;Microfabrication;Microscopic;Modeling;Molecular;monolayer;Mouse Cell Line;Mus;North Carolina;novel;OLFM4 gene;Organoids;Pathogenesis;Pathway interactions;Patients;Phenotype;Phosphorylation;Physicians;Physiological;Porosity;Process;progenitor;Public Health;receptor;receptor expression;Receptor Signaling;Reporter;Research;Resolution;response;RNA analysis;Role;Scientist;Signal Transduction;single-cell RNA sequencing;skills;Specific qualifier value;STAT3 gene;Stat3 protein;stem;stem cell biology;stem cell differentiation;stem cell division;stem cell expansion;stem cell fate;stem cell proliferation;stem cell self renewal;stem cells;Surface;System;Techniques;Technology;Testing;Tetracyclines;theories;Thick;Time;tissue regeneration;tissue repair;tool;Training;transcriptomics;Ulcerative Colitis;Universities;Visualization;Volatile Fatty Acids;Western Blotting;wound healing

PROJECT_TITLE: A Novel Planar Crypt Microarray for Real-Time Evaluation of Human Intestinal Stem Cell Fate


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Down Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PISCATAWAY

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative: Down syndrome (DS), caused by triplication of human chromosome 21, is the most common genetic origin of intellectual disability. Here, we propose to employ a novel human microglial mouse brain model that is created by using human DS induced pluripotent stem cells to study the role of human microglia in DS in vivo. Results from this study will unravel the pathogenic role of microglia in DS and identify molecules that can be targeted to improve microglial function for the treatment of DS.

PI_NAMEs: JIANG, PENG  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Affect;Animal Behavior;Animals;Behavior;Behavioral;Biological;Brain;brain abnormalities;brain cell;brain tissue;Candidate Disease Gene;cell type;Cells;Chimera organism;Chromosome 21;Cognitive deficits;comparison control;CRISPR/Cas technology;Development;developmental disease;Disease;disease phenotype;dosage;Down's Syndrome;Engraftment;Environment;Exhibits;Gene Expression Profile;Generations;Genes;Genetic;Genetic Transcription;glial cell development;Hippocampus;Homeostasis;Human;Human Chromosomes;human induced pluripotent stem cells;IFNAR1 gene;Immune;Impairment;improved;In Vitro;in vitro Model;in vivo;Individual;induced pluripotent stem cell;induced pluripotent stem cell technology;insight;Intellectual functioning disability;Interferons;Learning;Link;Macrophage;Maintenance;Memory;memory process;Microglia;Mind;Modeling;Molecular;mouse model;Mus;nerve stem cell;neural circuit;neural network;Neurons;new therapeutic target;novel;novel therapeutics;Organoids;Orthologous Gene;Pathogenesis;Pathogenicity;Pathologic;Pathology;patient derived induced pluripotent stem cells;Performance;Phenotype;Play;Property;Regulation;Research;response;Rodent;Role;single-cell RNA sequencing;Specific qualifier value;stem cells;Synapses;synaptic function;Synaptic plasticity;synaptic pruning;System;Technology;Testing;Tissues;tool;transcriptome;Transgenic Mice;Trisomy

PROJECT_TITLE: Understanding Down Syndrome Brain Development Using Human iPSC-Based Mouse Chimeras

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Immunotherapy;Prevention

ORG_CITY: AUGUSTA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: Overall Narrative Cardiovascular disease remains a leading cause of death world-wide. Immune cells (B cells, T cells, monocytes, and macrophages) are key protective cells in blood vessels. But, unfortunately, these cells can functionally change to increase cardiovascular disease. The goal of our Program is to understand how and why these changes occur in order to prevent them so that the immune cells continue to function in a protective manner. We will tackle these goals by studying human subjects with low and high CAD risk in three clinical cohorts, and in well-defined mouse models of atherosclerosis. The end goal of our studies is to identify safe new therapeutic strategies targeting immune cell function to limit cardiovascular disease.

PI_NAMEs: HEDRICK, CATHERINE C (contact)

PROGRAM_OFFICER_NAME: CHEN, JUE

PROJECT_TERMS: adaptive immune response;Address;Angiography;Anti-Cytokine Therapy;Anti-Inflammatory Agents;Antigens;Aorta;Apolipoproteins;Apolipoproteins B;Arterial Fatty Streak;Arteries;atherogenesis;atheroprotective;Atherosclerosis;B-Lymphocyte Subsets;B-Lymphocytes;Blood Vessels;Cardiac Catheterization Procedures;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Cause of Death;CCR6 gene;CD8-Positive T-Lymphocytes;Cell Communication;Cell Physiology;Cell Reprogramming;Cells;Cholesterol;Chronic;Clinical;Clinical Data;Clinical Trials;cohort;Colchicine;Communication;Coronary;Coronary Arteriosclerosis;coronary plaque;data sharing;Development;Disease;disorder risk;Dose;Educational process of instructing;Enrollment;Epitopes;Event;follow-up;Genetic Transcription;Goals;high dimensionality;Host Defense;Human;human subject;Immune;immune function;Immune response;Immune system;Immune Targeting;Immunity;Immunoglobulin M;immunoregulation;Impairment;Incidence;Infection;Inflammatory;Innate Immune Response;Interleukin-1 beta;Intervention;Laboratories;Link;Lipids;Lipoproteins;Longitudinal cohort;Low-Density Lipoproteins;lymph nodes;Lymphocyte;Lymphoid Tissue;Macrophage;Measures;member;Membrane Microdomains;Metabolic;Metabolism;Modeling;Molecular;Monoclonal Antibodies;monocyte;mouse model;Multi-Ethnic Study of Atherosclerosis;Mus;Myelogenous;Myeloid Cells;National Heart, Lung, and Blood Institute;natural antibodies;Nature;novel therapeutic intervention;Outcome;Outcome Study;oxidized lipid;oxidized low density lipoprotein;Patients;Pattern;Peptide Sequence Determination;Peptides;Peripheral Blood Mononuclear Cell;Phase III Clinical Trials;Placebos;Plasma;Play;prevent;Production;programs;Proteins;Reaction;receptor;Regulation;Research;response;Role;Seminal;Signal Transduction;T cell response;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic immunosuppression;Thrombosis;Training;transcriptome sequencing;Universities;Virginia;Work;X-Ray Computed Tomography

PROJECT_TITLE: Immune Cell Interactions in Atherosclerosis


NIH_SPENDING_CATS: Aging;Chronic Obstructive Pulmonary Disease;Emphysema;Lung;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

ORG_STATE: CO

PHR: Aging is associated with loss of lung structure, declining function, and increased susceptibility to lung disease, together termed senile emphysema. The goal of this proposal is to address this knowledge gap by first defining the mechanisms that result in loss of the novel adult mesenchymal vascular progenitor (ABCG2pos MVPC) function contributing to accelerated lung aging and increased susceptibility to emphysema in the aged population. Secondly, we will define whether progenitor rescue with cell therapy or interventional treatment will restore lung structure and function, attenuating lung aging and susceptibility to emphysema in the aged population.

PI_NAMEs: MAJKA, SUSAN M (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Acceleration;Address;Adult;aged;Aging;aging population;angiogenesis;Area;Biological Models;Blood Vessels;Cell Therapy;Cells;Collaborations;Colorado;Development;Environment;epithelial stem cell;exposure to cigarette smoke;FDA approved;follower of religion Jewish;Functional disorder;Goals;Homeostasis;in vitro Model;in vivo;International;Intervention;Knowledge;loss of function;Lung;Lung Diseases;Mesenchymal;Mission;novel;Pathway interactions;Predisposition;Process;progenitor;programs;Pulmonary Emphysema;Regulation;Research;Senility;Signal Transduction;stem cell differentiation;stem cell function;stem cell population;stem cell therapy;Structure;Therapeutic;Time;Tissues;Universities;Vascular Diseases;Vascular remodeling

PROJECT_TITLE: Mesenchymal Vascular Progenitor Depletion Promotes Lung Aging and Susceptibility to Emphysema


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Maternal Health;Maternal Morbidity and Mortality;Prevention;Women's Health Research

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: PROJECT NARRATIVE This proposal would substantially expand our understanding of postpartum-related breast cancers (PRBCs) by: 1) defining proliferative and immune effects associated with pregnancy and healthy postpartum involution (PPI) after weaning; 2) assessing how breast cancer risk factors affect the intensity of inflammation associated with PPI, thereby identifying potential candidates for prevention; 3) defining an immune biomarker panel (i.e., PRBC Immune Score) that distinguishes inflammation associated with development of PRBCs from healthy PPI and 4) testing whether aspirin can reduce inflammatory changes in the breast linked to development of PRBCs (i.e., lower PRBC Immune Score). Further, by assessing the correlation of epidemiologic risk factors and inflammatory markers in blood and urine with changes in inflammation in breast tissues associated with a trial of aspirin, we aim to identify characteristics of women who may respond favorably to an anti-inflammatory PRBC preventive intervention. Thus, the knowledge gained from the three synergistic aims proposed in this application may help identify women at increased risk of PRBCs and identify candidates for short-term, well- tolerated preventive interventions with anti-inflammatory or immune agents.

PI_NAMEs: RADISKY, DEREK C;RUDDY, KATHRYN JEAN;SHERMAN, MARK E (contact)

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: Address;adipokines;Affect;Aftercare;Age;aged;Algorithms;Anti-Inflammatory Agents;Arachidonic Acids;Area Under Curve;Aspirin;BCL1 Oncogene;BCL2L1 gene;BCL2L11 gene;Benign;Biological Assay;biomarker panel;Biopsy;Birth;Blood;Breast;Breast biopsy;breast cancer diagnosis;Breast Cancer Prevention;breast cancer progression;Breast Cancer Risk Factor;Breast Diseases;C-reactive protein;candidate identification;carcinogenicity;Characteristics;Chemoprevention;Childbirth;Clinic;Clinical;Clinical Trials;Contralateral;cyclooxygenase 2;Development;digital;Dinoprostone;Discrimination;DNA Damage;early onset;efficacy evaluation;Eicosanoids;Enrollment;Epidemiologic Factors;Epidemiology;Epithelial Cells;Estrogen Receptors;Estrogens;Family history of;First Births;follow-up;Freezing;Frequencies;Gamma-H2AX;High Risk Woman;Immune;Immune response;Immune Targeting;Immunohistochemistry;Immunologic Markers;Immunooncology;Immunosuppression;improved;In Situ;individualized prevention;Inflammation;Inflammatory;inflammatory marker;innovation;Insulin;Knowledge;Label;Lesion;Link;Lobule;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammography;Measures;Modeling;molecular subtypes;mouse model;MS4A1 gene;Multiparity;nano-string;Non-Steroidal Anti-Inflammatory Agents;North Carolina;Nulliparity;Operative Surgical Procedures;parity;parous;Participant;Pathogenesis;Pathology;Pathway interactions;Patients;Persons;Postpartum Period;Pre-Clinical Model;predictive signature;Pregnancy;Prevention;Prevention strategy;Prevention trial;Preventive;preventive intervention;primary endpoint;Process;Prognosis;Prostaglandin Production;Prostaglandins;Proteins;Questionnaires;Receiver Operating Characteristics;Reporting;Research;Risk;Risk Factors;Risk Marker;risk prediction;RNA;Sampling;Schedule;secondary endpoint;senescence;Serum;Severity of illness;Site;Specimen;Stains;Testing;Time;Tissue Banks;Tissue Microarray;Tissues;Universities;Urine;Weaning;Woman;wound healing;young woman

PROJECT_TITLE: Targeted Prevention of Postpartum-Related Breast Cancer (PRBC)

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative Opioid use disorder is characterized by continued use of the drugs despite a knowledge of negative consequences. This project will entail careful investigation of prefrontal cortex circuits involved in opioid-induced risk-taking behavior in rats. Because the proposed experiments include recordings and manipulations of prefrontal cortex activity, a brain structure that can be targeted clinically through noninvasive technologies such as transcranial magnetic stimulation, the results may shed light on the development of novel therapies for psychiatric disorders characterized by risky decision making.

PI_NAMEs: QUAVE, CANA  (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: addiction;Affect;Affective;Animals;approach/avoidance behavior;Area;Attention;avoidance behavior;Awareness;Behavior;behavior prediction;Behavioral;behavioral phenotyping;Biological;Brain;Cessation of life;Choice Behavior;Clinical;cognitive function;conditioned place preference;conditioning;Conflict (Psychology);Cues;Decision Making;Development;drug reward;Drug usage;Drug user;Electrophysiology (science);Emotional;Executive Dysfunction;experimental study;Exposure to;Felis catus;Female;Fentanyl;fentanyl use;Food;Fostering;Fright;Goals;Health;Human;Impairment;in vivo;Individual;individual variation;Intake;Investigation;Knowledge;Link;male;Medial;Mental disorders;Modeling;Morphine;motivated behavior;Motivation;Negative Reinforcements;neural;neural circuit;neural patterning;Neuroanatomy;neuromechanism;Neurons;novel;novel strategies;novel therapeutics;Nucleus Accumbens;Odors;Opiate Addiction;Opioid;opioid exposure;opioid misuse;opioid use;opioid use disorder;opioid withdrawal;optogenetics;Pathway interactions;Pattern;Pharmaceutical Preparations;Phenotype;Population;Positive Reinforcements;preference;Prefrontal Cortex;Process;Public Health;Rattus;Relapse;Research;response;Rewards;Risk;Risk Behaviors;Risk Reduction;Risk Taking;Rodent;Rodent Model;Role;Stimulus;Structure;Structure of paraventricular nucleus of thalamus;substance use;Substance Use Disorder;Synaptic plasticity;synthetic opioid;Techniques;Technology;Testing;tool;Transcranial magnetic stimulation;United States

PROJECT_TITLE: Investigating the role of prefrontal cortex circuits in opioid-induced risk-taking behavior


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Data Science;Infectious Diseases;Networking and Information Technology R&D (NITRD);Social Determinants of Health

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE This R25 Big Data analytics (BDA) emerging scholar (R25 e-Scholar) training program in infectious disease areas for racial and ethnic minority undergraduate students will contribute to our efforts to address the nationwide shortage of a diverse data science workforce in NIAID-focused areas. With an individualized active learning approach, the proposed program will provide minority undergraduate students with early exposure to and experience with BDA and infectious disease research and foster their interests and competencies in BDA research in infectious disease. The training program will also foster a more diverse research environment at UofSC and across the state and encourage minority undergraduate students to pursue future Big Data research in the prevention, treatment, discovery, prediction, or forecasting of HIV, COVID-19 and other infectious, immunologic, or allergic diseases.

PI_NAMEs: LI, XIAOMING  (contact);ZHANG, JIAJIA

PROGRAM_OFFICER_NAME: MOTEN, CARMEN

PROJECT_TERMS: Academic Training;Active Learning;Address;Allergic Disease;Area;Bachelor's Degree;Big Data;Big Data Methods;big-data science;Biological Sciences;Businesses;career;Career Mobility;college;Communicable Diseases;Communities;community engagement;Competence;Complex;computerized data processing;COVID-19;Data;data acquisition;Data Science;Development;Diagnosis;digital;diverse data;Diverse Workforce;Doctor's Degree;education research;Educational Curriculum;Electronic Health Record;Entrepreneurship;Environment;ethnic minority;ethnic minority population;Ethnic Origin;experience;Exposure to;Faculty;financial incentive;Fostering;Funding;Future;genomic data;Genomics;Goals;graduate student;hands on research;Health;Health Care Research;health disparity;health science research;Health Sciences;Healthcare;Historically Black Colleges and Universities;HIV;Immune System Diseases;Individual;Industry;Infectious Diseases Research;Infrastructure;interest;Knowledge;Manuscripts;member;Mentors;Methodology;Methods;minority student;minority undergraduate;Mission;Modeling;National Institute of Allergy and Infectious Disease;peer coaching;Persons;Population;population health;Prevention;Process;programs;Public Health;public health research;Race;racial minority;racial minority population;Records;recruit;Research;Research Project Grants;Research Training;response;responsible research conduct;role model;Scholars Program;Schools;skills;social media;South Carolina;Students;summer institute;symposium;Talents;Technology;Time;Training;Training and Education;Training Programs;undergraduate student;United States National Institutes of Health;Universities;Visualization;Wages;wearable data;wearable device;Workforce Development;Writing

PROJECT_TITLE: Big Data Analytics Emerging Scholar (e-Scholar) Program for Minority Students


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Neurosciences;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Narrative (Public Health Relevance) Although quitting smoking is the most important action a smoker can take to prevent premature mortality, cessation has proven difficult. Observed relations between craving and relapse suggest that novel approaches to craving relief are sorely needed, and initial findings support the use of olfactory cues to control cravings. Integrating theory and research derived from three disciplines rarely applied to smoking research (olfaction, emotion, and cognition), the application combines brain imaging and behavioral research to understand how odors work to reduce craving and to identify ways of matching odors to individual smokers, setting the stage for future research testing its value as a component of a smoking cessation intervention and for testing the impact of olfaction on a variety of mind/body experiences.

PI_NAMEs: COUTANCHE, MARC NIGEL;SAYETTE, MICHAEL ANDREW (contact)

PROJECT_TERMS: addiction;Address;Affect;Affective;Attention;Attenuated;Behavior assessment;Behavioral;Behavioral Mechanisms;Behavioral Research;Brain;Brain imaging;Cause of Death;Characteristics;cigarette craving;Clinical;Code;Cognition;Cognitive;cognitive process;cognitive task;Cognitive Therapy;cost;craving;Cues;Data;Dimensions;Discipline;discounting;Ecological momentary assessment;Emotional;Emotions;Environment;experience;experimental study;Face;Facial Expression;Fingerprint;food craving;Functional Magnetic Resonance Imaging;Habits;hedonic;in vivo;indexing;Individual;Individual Differences;infancy;innovation;Interdisciplinary Study;Intervention;Intervention Studies;Investigation;Link;Measures;Mediating;Mediator;Memory;Methodology;Methods;mind/body;Modality;Modeling;Moods;multimodality;Multivariate Analysis;Natural Products;Nature;neural;neurobehavioral;neurocognitive test;Neurotic Disorders;nicotine patch;non-verbal;novel;novel strategies;Odors;Outcome;Pain;Patient Self-Report;Pattern;pharmacologic;Phase;precision medicine;Premature Mortality;pressure;prevent;Process;Proxy;public health relevance;Reaction;Relapse;Research;response;Risk Behaviors;Sampling;Science;Series;Short-Term Memory;Signal Transduction;Smell Perception;Smoke;Smoker;Smoking;smoking abstinence;smoking cessation;Smoking Cessation Intervention;smoking cue;Subgroup;System;Testing;theories;Time;Tobacco;translational study;Variant;Visceral;Withdrawal;Woman;Work

PROJECT_TITLE: Cognitive and Affective Mechanisms Underlying an Olfactory Approach to Modify Cigarette Craving: A Neurobehavioral Investigation

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE Respiratory pathogens such as influenza viruses constitute a major human health problem worldwide, resulting in up to 600,000 deaths every year. One approach to enhance protective immunity against these pathogens is through the generation of tissue-resident memory T cells in the lung that are uniquely positioned to provide immediate effector functions at the site of pathogen entry, but the mechanisms guiding their development and maintenance remain poorly defined. The goals of this proposal are to determine the cellular and molecular events that regulate the generation and longevity of lung-resident memory T cells in mice and humans in order to better guide future cell-mediated vaccine design against respiratory pathogens.

PI_NAMEs: KOHLMEIER, JACOB E (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Animal Model;Antibody Response;Automobile Driving;biobank;Biology;Cell Count;Cells;Cellular biology;Cessation of life;design;Development;Epigenetic Process;Event;Future;Generations;Genetic Transcription;Goals;Health;Hemagglutinin;Human;Humoral Immunities;Immunity;improved;Infection;Influenza;influenza infection;Influenza vaccination;influenzavirus;Knowledge;Longevity;Lung;Maintenance;Mediating;Medical Care Costs;Molecular;Mus;novel;pathogen;Positioning Attribute;programs;Proteins;Pulmonary Challenge;respiratory pathogen;response;Sampling;seasonal influenza;Site;Structure of parenchyma of lung;Symptoms;T memory cell;Testing;Time;tissue resident memory T cell;Tissues;transmission process;Vaccination;vaccination strategy;Vaccine Design;vaccine development;vaccinology;Viral;Viral Load result

PROJECT_TITLE: Cellular and molecular programming of lung resident T cell memory


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Lung;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: FORT WORTH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

PHR: The proposed phase I trial is relevant to public health because it is expected to develop a safe and effective intervention to treat cognitive deficit and, thus, improve quality of life for patients with amnestic mild cognitive impairment (aMCI), an early and potentially treatable stage in the development of Alzheimer’s disease (AD). By slowing or preventing cognitive deterioration in aMCI patients, the proposed research is relevant to the NIH’s mission that seeks to develop fundamental knowledge to help prevent, halt and reverse cognitive decline and neurodegeneration associated with AD-dementias.

PI_NAMEs: SHI, XIANGRONG  (contact)

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: Address;Adult;aged;Air;Alzheimer's Disease;American;amnestic mild cognitive impairment;Attention;Blood Pressure;Brain;Brain-Derived Neurotrophic Factor;Breathing;Cardiac;Caregivers;cerebrovascular;Cerebrovascular Circulation;Cerebrum;Chronic Obstructive Pulmonary Disease;Cognitive;Cognitive deficits;cognitive function;cognitive performance;Control Groups;Coronary Arteriosclerosis;Data;Dementia;Deterioration;Development;disability;effective intervention;efficacious intervention;Elderly;Emotional;Enrollment;Epidemic;Erythropoietin;evidence base;Exercise Tolerance;Family;Financial Hardship;follow up assessment;Fostering;Gases;Goals;Growth;Hemodialysis;Hippocampus;Human;human old age (65+);hypertensive;Hypoxemia;Hypoxia;Impaired cognition;improved;Individual;innovation;Intervention;intravenous injection;Investigation;Knowledge;Measures;Memory Disorders;Memory impairment;men;mild cognitive impairment;Mission;Nerve Degeneration;Neurocognitive;neurogenesis;Neuronal Plasticity;neuroprotection;Nonpharmacologic Therapy;novel;novel therapeutics;older patient;Patients;Perfusion;Periodicity;Pharmaceutical Preparations;phase I trial;Physiological;Placebo Control;pre-clinical;prevent;preventive intervention;Psyche structure;Public Health;Quality of life;Randomized;recombinant human erythropoietin;Reporting;Research;Rest;Risk;Safety;Serum;Short-Term Memory;Single-Blind Study;Societies;Therapeutic Intervention;therapeutically effective;tissue oxygenation;Training;Training Programs;United States National Institutes of Health;Woman;young adult

PROJECT_TITLE: Intermittent Hypoxia Training: A Novel Therapy for Mild Cognitive Impairment


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Atherosclerosis;Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: TUCSON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE This project aims to understand the contributions of extracranial carotid artery disease (ECAD) to brain health and Alzheimer’s disease (AD) risk. Using cross-sectional and prospective longitudinal studies, we will attempt to identify: 1) which early AD-specific pathological changes are associated with ECAD, 2) mechanisms of ECAD effects, and 3) whether ECAD-specific treatment improves/prevents relevant outcomes. This will help elucidate vascular contributions to AD risk and has the potential to greatly benefit two large patient populations: those with ECAD and those at risk for AD, which we hypothesize overlap more than is currently appreciated.

PI_NAMEs: WEINKAUF, CRAIG C (contact)

PROGRAM_OFFICER_NAME: GHALEH, MARYAM X

PROJECT_TERMS: Affect;Age;Aging;Alzheimer's Disease;Alzheimer's disease risk;Anisotropy;Apolipoprotein E;Atherosclerosis;Blood;Blood flow;Blood Vessels;blood-based biomarker;Brain;brain health;Brain Pathology;brain volume;cardiovascular risk factor;Carotid Arteries;Carotid Artery Diseases;Carotid Atherosclerotic Disease;Carotid Endarterectomy;Carotid Stenosis;Cephalic;cerebral hypoperfusion;Cerebral small vessel disease;cerebrovascular;Cerebrum;Clinical Trials;Cognition;cognitive function;cohort;Cohort Studies;Cross-Sectional Studies;Data;Data Analyses;defined contribution;Dementia;dementia risk;Diabetes Mellitus;Disease;Education;effective therapy;Endothelium;Evaluation;Event;follow-up;Goals;Hippocampus;Hypertension;hypoperfusion;imaging scientist;Impaired cognition;improved;Inflammation;inflammatory marker;insight;Intervention;Knowledge;Lesion;Location;longitudinal, prospective study;Magnetic Resonance Imaging;Measures;Metabolic;multidisciplinary;Nerve Degeneration;neurocognitive test;Neurofibrillary Tangles;novel;Nutrient;Observational Study;Operative Surgical Procedures;Outcome;Participant;Pathologic;Pathway interactions;patient population;Patient Recruitments;Patient Selection;Patients;Physiological;Physiology;Play;Population;predicting response;prevent;Prevention;Process;prospective;recruit;Relative Risks;Research Design;response;Risk;Risk Reduction;risk stratification;Role;Secondary to;sex;Smoking;Stenosis;Structure;systemic inflammatory response;targeted treatment;Testing;ultrasound;United States;vascular contributions;Vascular Dementia;Vascular Diseases;vascular risk factor;white matter;Work

PROJECT_TITLE: Extracranial Carotid Atherosclerosis Contributions to Cognitive Impairment and Alzheimer's Disease Risk

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]