ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Social Determinants of Health;Substance Misuse

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

PHR: PROJECT NARRATIVE The severe shortage of mental health clinicians plays a crucial role in the unmet need for alcohol use disorder treatment, creating an urgent and critical public health issue in the United States. To mitigate the clinician shortage problem, Congress has significantly expanded the National Health Service Corps (NHSC) since 2009, which is the largest public policy intervention to attract clinicians to practice in mental health professional shortage areas. This proposed project aims to examine whether the NHSC expansion reduced the unmet need for alcohol use disorder treatment and improved disparities in alcohol use disorder treatment and outcomes in mental health professional shortage areas.

PI_NAMEs: YU, HAO  (contact)

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: Accounting;Address;Adverse event;Affect;Affordable Care Act;alcohol availability;alcohol misuse;alcohol use disorder;Alcohols;American;Area;Behavior Therapy;Budgets;Centers for Disease Control and Prevention (U.S.);Cessation of life;Clinical;Congresses;cost;Data;Data Files;Dental Care;Diagnosis;Disadvantaged;Disparity;disparity reduction;Economic Burden;Emergency department visit;evidence base;experience;Funding Agency;Future;geographic disparity;Geographic Locations;Geography;Goals;Growth;Health;Health Care Reform;Health Personnel;health professional shortage areas;Health Services Accessibility;Heterogeneity;Hospitalization;improved;interest;Intervention;Intoxication;Investments;Literature;low socioeconomic status;Medicaid;Mental Health;Methods;Minority Groups;mortality;National Health Service Corps;National Institute on Alcohol Abuse and Alcoholism;Natural experiment;Patient Self-Report;Persons;Pharmacological Treatment;Play;Policies;policy implication;Policy Maker;Population Group;Prevalence;Primary Care;Privatization;Professional counselor;programs;Psychiatrist;Psychologist;Psychotic Disorders;Public Health;public health priorities;Public Policy;Quasi-experiment;Recovery;Reduce health disparities;reduced alcohol use;Role;rural area;Social Workers;Societies;treatment and outcome;treatment disparity;underserved area;United States;Urban Community;Withdrawal

PROJECT_TITLE: Reducing disparities in alcohol use disorder treatment in underserved areas

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 GG (03)]


ADMINISTERING_IC: HD

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Infant Mortality;Mental Health;Neurosciences;Pediatric;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative This project will explore altered brain MRI features that are linked to cognitive dysfunction in congenital heart disease (CHD) from both a pre-operative infant and an adult cohort. Our study leverages these unique and comprehensive data with advanced neuroimaging analyses to bridge a crucial gap in our knowledge of how prenatal, postnatal operative and environmental factors could affect brain development and longer-term cognitive outcomes in patients with CHD. Understanding which factors most impact the brain at these life stages will provide insight into when and where best to target treatments toward improving outcome throughout the lifespan.

PI_NAMEs: CHUNG, AI WERN  (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Address;Adult;Affect;Age;Age Months;aged;Area;autism spectrum disorder;Axon;Birth;Brain;brain magnetic resonance imaging;brain shape;Caring;Child;Child Rearing;Clinical;Cognitive;cognitive testing;cohort;Communication;Complex;Congenital Abnormality;congenital heart abnormality;connectome;Cyanotic heart disease;d-transposition of the great arteries;Data;Development;Diffuse;Diffusion Magnetic Resonance Imaging;Disease;Disease Outcome;disorder subtype;Early Intervention;Environmental Risk Factor;Equity;Executive Dysfunction;executive function;Exhibits;Foundations;Gene Abnormality;Gene Expression;Genetic;Goals;imaging study;Impaired cognition;Impairment;improved;improved outcome;in utero;in vivo;Independent Living;infancy;Infant;Influentials;innovation;insight;Intervention;Knowledge;Life;Life Experience;life span;Link;Live Birth;Longitudinal Studies;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;Medical;Mental Health;Modeling;myelination;Nervous System Disorder;neural;Neurocognitive Deficit;Neurodevelopmental Disability;neuroimaging;Neuropsychology;novel;novel marker;Operative Surgical Procedures;Outcome;Outcome Measure;Pathway interactions;Patient Care;Patients;Peripheral;postnatal;Postoperative Period;prenatal;prenatal therapy;Process;psychosocial outcome;response to injury;Role;Services;Severities;Socioeconomic Status;Structure;Synaptic Transmission;Vertebral column;white matter

PROJECT_TITLE: Does Altered Brain Connectivity Correlate with Developmental Outcomes and Executive Function in Congenital Heart Disease?

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Our ability to treat anxiety- and trauma-related psychiatric disorders is limited by our ability to precisely control threat computations in a similar way across species. The goal of this project is to develop a translatable, naturalistic model for circuit-behavior linkages using the fear of heights which can be used to understand innate threat across species. Using neurotransmitter biosensors, head-mounted microendoscope calcium imaging, and computational modeling of virtual reality behavior will demonstrate the role of norepinephrine in the aversion to high places.

PI_NAMEs: KAYE, ALFRED P (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: 3-Dimensional;Amygdaloid structure;Anterior;Anxiety;Anxiety Disorders;Arousal;Attention;Behavior;behavior influence;Behavioral;Behavioral Model;Behavioral Paradigm;behavioral response;Biosensor;Calcium;Cessation of life;Computer Models;Computer software;Custom;Data;Development;Dimensions;Discrimination;Disease;Distress;Dose;Electrophysiology (science);Emotional;Emotions;Environment;Ethology;experience;Exploratory Behavior;Exposure to;Fiber;Floor;Foundations;Fright;Future;Genetic;Goals;Head;Height;high reward;high risk;Human;Image;Infant;insight;Insula of Reil;interest;Laboratories;Learning;Link;locus ceruleus structure;Medial;Mental disorders;Mental Health;microendoscope;Modeling;Monitor;Mus;National Institute of Mental Health;Nature;neural circuit;Neurons;Neurosciences;Neurotransmitters;noradrenergic;Norepinephrine;novel;novel therapeutics;Pattern;peer;Perception;Peripheral;pharmacologic;Pharmacology;Photometry;Play;Prefrontal Cortex;Process;programs;Psychological reinforcement;Research;Research Domain Criteria;response;Role;Running;sensor;Site;Stimulus;Symptoms;System;therapy development;Time;Trauma;Uncertainty;Validation;virtual;virtual human;virtual reality;virtual reality system;Visual;visual neuroscience;Visual System

PROJECT_TITLE: Noradrenergic circuits in heights avoidance: an ethological, translatable threat behavior

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Heart Disease;Neurodegenerative;Neurosciences;Physical Activity;Prevention

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Growing evidence suggests a close link between cardiovascular dysfunction and progression of Alzheimer's disease (AD), and cardiovascular risk factors are associated with an increased risk of developing AD. There is a gap in our knowledge of the interplay between vascular and metabolic health of the brain and heart in AD, how those key functions may be improved by routine exercise to slow down AD progression, and any gender differences. In this pilot study, we will evaluate the feasibility of two advanced, non-invasive, and translatable imaging techniques in an AD model that rapidly recapitulates major features of AD amyloid pathology, with a moderate exercise remedy over time to monitor their metabolic and vascular functions in the brain and heart associated with amyloid pathogenesis, and gender differences.

PI_NAMEs: YEN, YI-FEN  (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;American;Amyloid;amyloid pathology;arterial spin labeling;Astronomy;Autopsy;Blood;Blood flow;Blood Vessels;Brain;brain health;Brain imaging;Cardiac;Cardiac health;cardiac magnetic resonance imaging;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Caregivers;Caring;Cause of Death;Cerebrovascular Circulation;Cine Magnetic Resonance Imaging;Citric Acid Cycle;Classification;cognitive function;Contrast Media;Data;Development;Disease Progression;Echocardiography;EFRAC;Environment;Environmental Risk Factor;Exercise;exercise regimen;Female;Functional disorder;Future;Gender;gender difference;Glutamates;Glycolysis;Grant;Health;Heart;Heart Diseases;heart function;heart metabolism;high risk;Hour;Human;human old age (65+);Image;Imaging Techniques;Impairment;improved;in vivo;Individual;Investigation;Knowledge;Label;Life Style;lifestyle factors;Link;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;male;Measurement;Measures;men;Metabolic;metabolic imaging;Mitochondria;mitochondrial dysfunction;Moderate Exercise;modifiable risk;molecular imaging;Monitor;mouse model;Multimodal Imaging;multimodality;Mus;Nerve Degeneration;next generation;novel;Organ;Oxidative Stress;Oxygen;Pathogenesis;Perfusion;Physiologic pulse;Pilot Projects;Population;Prevalence;Process;Production;Pyruvate;radio frequency;Randomized;Recommendation;Reporting;Research;Risk;Risk Factors;sedentary;success;Techniques;Time;Tissues;tool;Transgenic Mice;United States;Woman

PROJECT_TITLE: Next generation metabolic imaging of the effect of exercise on mitochondrial function in Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-Q (81)]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative:  The proposed work promises to develop the use of an important new tool for studying neurotransmitter release at healthy and ALS model mouse neuromuscular synapses. This tool will initially be applied to the study of heterogeneity of individual transmitter release site function by correlating active zone structure and function. Such an investigation promises to transform the ways in which we study and understand presynaptic physiology and modulation of neurotransmitter release in healthy and disease states.

PI_NAMEs: BADAWI, YOMNA  (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: Acetylcholine;Adult;Affect;Age;Age Months;alpha Bungarotoxin;Amyotrophic Lateral Sclerosis;Animal Model;Calcium;Calcium Channel;Cessation of life;Cholinergic Receptors;Collection;Communication;Data;Development;Disease;Disease Progression;Drosophila genus;Dyes;Event;Heterogeneity;Immunoglobulin Fragments;Impairment;improved;Individual;individual variation;Investigation;Maps;Measures;Methods;Monoclonal Antibodies;Motor Neurons;mouse model;Mus;Muscle;Neurodegenerative Disorders;neuromuscular;Neuromuscular Diseases;Neuromuscular Junction;Neurons;neurotransmitter release;new therapeutic target;Nicotinic Receptors;novel;novel strategies;Optical reporter;Optics;Paralysed;Pathologic;PHluorin;Physiological;Physiological Processes;Physiology;Play;postsynaptic;presynaptic;Probability;receptor function;Regulation;Reporter;Research Personnel;Resolution;Role;segregation;sensor;Site;Spatial Distribution;Structure;Synapses;Synaptic Membranes;Synaptic Vesicles;tool;Uncertainty;Validation;Vesicle;vesicular release;Visualization;Wild Type Mouse;Work

PROJECT_TITLE: Development of a novel optical probe to study functional heterogeneity of individual neurotransmitter release sites at the neuromuscular junction

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: NORTH CHICAGO

ORG_NAME: ROSALIND FRANKLIN UNIV OF MEDICINE & SCI

ORG_STATE: IL

PHR: Project Narrative Gene transfer using viral vectors for cellular delivery has emerged as a widespread and powerful tool for research and increasingly also for clinical therapeutic use. Selectivity of cell type targeting, referred to as viral tropism, is important for fidelity but is not absolute, leading to off-target effects that may, or may not, be mitigated by cell specific promoters driving transgene expression. We propose two lentiviral pseudotyping gene transfer strategies, one of which will allow specific targeting of any mammalian cell type expressing the avian TVA receptor and a second of which will specifically and exclusively target one glial progenitor cell type in the mammalian CNS.

PI_NAMEs: PETERSON, DANIEL ALAN (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Address;Adopted;Adult;Antigens;Astrocytes;Automobile Driving;Binding;Birds;Body System;Brain;Cell Cycle;Cell Lineage;Cell Reprogramming;cell type;Cells;Characteristics;Chemicals;Clinical;design;Development;Disease;Endothelial Cells;experimental study;Exploratory/Developmental Grant;follow-up;Gene Delivery;Gene Expression;Gene Modified;gene therapy;Gene Transfer;Genes;improved;in vivo;Infection;Instruction;interest;Investigational Therapies;knock-down;Label;Lentivirus;Mammalian Cell;Membrane;Neurons;oligodendrocyte progenitor;Optics;Outcome Study;overexpression;Pathologic;Platelet-Derived Growth Factor alpha Receptor;Play;Population;Predisposition;programs;Proliferating;promoter;Rabies virus;receptor;Reporter Genes;Reporting;Research;research study;Retroviral Vector;Role;Signal Transduction;Specific qualifier value;Specificity;stem cell genes;stem cells;success;Suggestion;Synapses;Therapeutic;Therapeutic Uses;tool;Transcriptional Regulation;transgene delivery;transgene expression;Transgenes;Tropism;Tva receptor;vector;Viral;Viral Vector

PROJECT_TITLE: Selective targeting of CNS cells in vivo for multiple transgene delivery and neuronal reprogramming

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: PHILADELPHIA

ORG_DEPT: PATHOLOGY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: A major complication of cataract surgery is the development of the lens fibrotic disease, Posterior Capsule Opacification (PCO). The proposed studies will investigate the molecular mechanisms by which mitochondrial remodeling promotes lens fibrotic disease. The proposed research is relevant to public health, as findings from these studies are expected to lead to the development of new mitochondrial-targeted treatment strategies for mitigating or blocking the development of PCO.

PI_NAMEs: SEIFERT, ERIN ;WALKER, JANICE LYNN (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Address;Animal Model;Automobile Driving;Bioenergetics;Biology;capsule;Cataract Extraction;Cell Physiology;Cells;Cellular biology;Cellular Metabolic Process;clinically relevant;Complication;Confocal Microscopy;Cytoskeleton;Data;Development;Disease;Electron Transport;Elements;epigenetic regulation;Event;Fibroblasts;Fibrosis;Foundations;Genes;Glycolysis;Goals;Human;human tissue;Image;imaging study;inhibitor;Injury;insight;Lasers;lens;Lens development;Link;Metabolic;Metabolism;Methods;Microscopy;Microtubules;Mitochondria;mitochondrial metabolism;Modeling;Molecular;Morphology;Motility;novel;Operative Surgical Procedures;Outcome;oxidation;Oxidative Phosphorylation;Patients;Phenotype;Play;Positioning Attribute;prevent;Production;Public Health;Reactive Oxygen Species;Reporting;Research;Resolution;Resources;response;Role;Signal Transduction;small molecule;Source;Surgical Injuries;Surgical wound;targeted treatment;Techniques;Testing;Tissues;trafficking;transcriptome;transcriptomics;Travel;treatment strategy;Up-Regulation;Vulnerable Populations;Work;wound healing

PROJECT_TITLE: Investigating the role of mitochondrial function in driving lens fibrotic disease

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: Columbus

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Public Health Relevance Statement With forecasts of the annual economic burden of autism spectrum disorders projected to reach $461 billion by 2025 in the US alone, the importance of validating neural biomarkers to evidence-based interventions cannot be underestimated. This study uses well-established electroencephalography (EEG) measures of auditory processing to examine the neural mechanisms underlying pervasive sensory symptoms in autism. Results generated here will validate a novel model that determines the role of top-down attention on sensory symptoms in autism and provide a framework to determine the effectiveness of attention interventions in autism.

PI_NAMEs: CRASTA, JEWEL ELIAS  (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: Address;adult with autism spectrum disorder;Affect;Age;Attention;Auditory;auditory processing;auditory stimulus;autism biomarker;autism spectrum disorder;autistic children;Behavior Therapy;Behavioral;Biological Markers;Brain;brain behavior;Childhood;Clinical;Clinical Management;Clinical Trials;Data;Diagnostic;Economic Burden;effectiveness evaluation;Electroencephalography;Equation;evidence base;Evidence based intervention;Foundations;Functional impairment;functional outcomes;Future;Goals;Impairment;improved;individuals with autism spectrum disorder;innovation;Intervention;Knowledge;Language;Measurement;Measures;Mediating;Methods;Modeling;Motor;neural;neuromechanism;novel;Parents;Patient Self-Report;peer;Performance;pharmacologic;potential biomarker;Process;public health relevance;Regulation;repetitive behavior;Reporting;response;Role;Sensory;sensory mechanism;social;Social Behavior;Symptoms;Testing;Time;Validation;Work

PROJECT_TITLE: Neural biomarkers of sensory symptoms in autism

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Lung;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Phox2b is one of the four transcription factors that defines the development, differentiation, and migration of RTN neurons, a critical set of CO2/H+-sensing respiratory chemoreceptor neurons in mice, and its expression persists throughout the postnatal period. In human patients, mutations in PHOX2B are diagnostic of congenital central hypoventilation syndrome (CCHS), characterized most famously by disruptions in CO2-dependent breathing and arousal reflexes. The precise transcriptional role of Phox2b in RTN neurons, and how disruption/mutation of Phox2b expression leads to the clinical signs associated with CCHS have not been determined. In this application, we propose a viral-mediated approach to examine effects of Phox2b depletion and mutation selectively in RTN chemoreceptor neurons implicated in CCHS to determine effects on gene expression and on CO2-dependent breathing and arousal.

PI_NAMEs: SHI, YINGTANG  (contact)

PROGRAM_OFFICER_NAME: SHARMA, KARLIE ROXANNE

PROJECT_TERMS: Afferent Neurons;Alveolar;Arousal;Autonomic Dysfunction;Autonomic nervous system disorders;Behavioral Assay;Brain Stem;Breathing;Carbon Dioxide;cDNA Expression;Cell Nucleus;Cells;Chemoreceptors;Clinical;cohort;congenital central hypoventilation syndrome;Congenital Megacolon;detector;Development;Diagnostic;Disease;Dysautonomias;experimental study;Functional disorder;Gene Expression;Genes;genetic analysis;genetic manipulation;Genetic Models;Genetic Transcription;genetic variant;GPR4 gene;Harvest;Homeobox;Human;Hypoventilation;Image;insight;knock-down;Length;loss of function;Mediating;Methods;migration;Molecular;Molecular Analysis;mouse genetics;Mus;mutant;Mutation;Neuroblastoma;Neurons;neuropathology;Neuropeptides;novel marker;Patients;polyalanine;postnatal period;programs;receptor;Reflex action;Regulation;Respiration;Respiration Disorders;respiratory;response;Role;selective expression;sensor;Sensory;sensory feedback;Severities;Signal Transduction;single-cell RNA sequencing;Sleep;small hairpin RNA;Symptoms;Technology;Testing;Transcript;transcription factor;Transcriptional Regulation;transcriptome;transcriptomics;Viral;Work

PROJECT_TITLE: Role of Phox2b in mouse respiratory chemoreceptor neurons

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 RD-1 (01)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Prevention;Rehabilitation;Social Determinants of Health;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE Climate change will exacerbate cardiovascular (CV) and respiratory/pulmonary (R/P) morbidity through increasing extreme temperatures and periods of high levels of air pollution from wildfires. Certain cancer therapies can increase breast cancer survivors' propensity for CV and R/P disease, and may increase survivors' susceptibility to health problems from climate change. We will determine whether: 1) survivors exposed to extreme temperature and air pollution prior to diagnosis have a higher risk for therapy-related CV and R/P problems, and 2) if post-diagnosis short term exposure to extreme temperature and air pollution during treatment increases survivors' risk for CV and R/P problems related to climate change.

PI_NAMEs: KIRCHHOFF, ANNE C (contact);VANDERSLICE, JIM ALBERT

PROGRAM_OFFICER_NAME: DELLAVALLE, CURT TAVIS

PROJECT_TERMS: Acute;Age;Air;Air Pollution;Behavior Therapy;Breast Cancer survivor;Breast Cancer survivorship;Breast Cancer therapy;Cancer Control;Cancer Survivor;Cancer Survivorship;cancer therapy;Cardiac health;cardiovascular risk factor;Cardiovascular system;Cessation of life;chemotherapy;childhood cancer survivor;climate change;climate impact;climate-related exposures;cohort;Data;data resource;Data Sources;density;Development;Diagnosis;Emergency department visit;epidemiologic data;Evaluation;Event;experience;Exposure to;extreme temperature;extreme weather;Face;Female;Female Breast Carcinoma;Grant;Health;health management;Heart;high risk;Hispanic;Hispanic Women;Hospitalization;Impairment;improved;indexing;Individual;innovation;interest;Late Effects;low socioeconomic status;Lung;Lung Diseases;lung health;lung injury;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Medical;model design;Morbidity - disease rate;mortality;novel;Oncologist;Outcome;Pattern;personalized medicine;Physiological;Population;Population Database;Predisposition;public health emergency;Recording of previous events;Resources;respiratory;response;Risk;risk mitigation;Sampling;Smoke;Subgroup;success;Supportive care;Survivors;Temperature;Tissues;Toxic effect;Treatment-related toxicity;United States;Utah;Wildfire;Woman;Work

PROJECT_TITLE: Breast cancer survivorship in the era of climate change: Impact of extreme weather, air pollution, and cancer therapy on heart and lung health

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: TOLEDO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS

PHR: Narrative The overarching goal of this project is to extend knowledge regarding the pathophysiology of AD progression to protein kinase signaling networks. Assessment of signaling networks will move the field beyond simple measures of gene expression, providing important insights for changes in protein function in the devastating and common disease.

PI_NAMEs: MCCULLUMSMITH, ROBERT E (contact);MELLER, JAREK ;WEN, ZHEXING

PROJECT_TERMS: Acceleration;Alzheimer's Disease;Alzheimer's disease pathology;area striata;Astrocytes;Autopsy;bioinformatics tool;Biological;Biological Assay;Biological Models;Biological Process;Brain;brain control;candidate identification;Cell Culture Techniques;Cell Physiology;Cells;Clinical Trials;Cognition;Complex;Data;Data Set;Development;Disease;Disease Progression;efficacious treatment;Elements;enzyme activity;Enzymes;Event;Experimental Designs;experimental study;Failure;familial Alzheimer disease;Female;Functional disorder;Gene Expression;Genetic;Glutamates;Goals;high reward;Hippocampus;Human;Human Genome;human model;improved;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;innovation;insight;Investigation;Knowledge;laser capture microdissection;male;Measures;Mediating;Microglia;mild cognitive impairment;Molecular;molecular pathology;Multiomic Data;multiple omics;Mus;network models;Neurons;novel;novel strategies;novel therapeutics;Nuclear;Pathologic;pharmacologic;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Prevalence;Probability;Property;protein function;Protein Kinase;Proteins;Proteomics;Protocols documentation;Recombinants;Research Personnel;Risk;Sampling;secondary outcome;Series;Serine;sex;Signal Transduction;success;Sum;Synapses;System;Threonine;Time;Tissues;Validation;Western Blotting;Work

PROJECT_TITLE: Investigation of active kinome networks in Alzheimer's dementia.

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Asthma;Autism;Brain Disorders;Climate-Related Exposures and Conditions;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Lung;Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: DAVIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Project narrative: In the last 20 years, rates of diagnoses for autism have increased at an alarming rate, and yet little is understood about its causes and treatment options are limited. By examining two increasingly common risk-related environmental factors – namely asthma and wildfire particulate matter – we will challenge current paradigms and isolate mechanisms related to microglia that may contribute to pathophysiology of autism. This hypothesis-driven integrative study combines immune, complex real-world environmental exposures, and epigenetic approaches to address a major gap in autism research and will provide critical information on the consequences of environmental contributions to risk for autism, helping to translate epidemiological observation into a functional model that can be utilized for further investigations and identify possible paths for prevention.

PI_NAMEs: ASHWOOD, PAUL  (contact)

PROGRAM_OFFICER_NAME: LAWLER, CINDY P

PROJECT_TERMS: Acute;Address;Adult;Affect;Air Pollution;allergic airway disease;Asthma;asthma exacerbation;asthmatic;Autism Diagnosis;autism spectrum disorder;autistic children;Autopsy;Brain;Brain Diseases;brain tissue;California;Cell Nucleus;Cells;Child;climate change;Complex;critical period;cytokine;Data;Development;Disease;disorder risk;DNA Methylation;Droughts;effective therapy;Endothelium;Environmental Exposure;Environmental Pollutants;Environmental Risk Factor;Epidemiology;Epigenetic Process;epigenetic regulation;epigenome;epigenomics;Epithelium;Exhibits;experimental study;Exposure to;Extrinsic asthma;Face;Factor Analysis;fetal;Fetal Development;Fever;Fire - disasters;Functional disorder;gene discovery;Gene Expression;Gene Expression Regulation;gene network;Genes;Genetic;Genomics;glial activation;glial cell development;Goals;Grain;Heritability;Hospitalization;Human;Hypersensitivity;Immune;immune activation;immune function;Immune response;Immune system;Immunologics;immunoregulation;Impairment;In Situ;Inflammatory;Inflammatory Response;innovation;interest;Intervention;Investigation;Laboratories;Lead;Life;Link;Liquid substance;maternal immune system;Mediating;Methylation;Microglia;model of autism spectrum disorder;Modeling;Modification;Molecular;Morphology;multiple omics;Mus;Neurobiology;neurodevelopment;Neurodevelopmental Disorder;Neurons;Neurotransmitters;novel;Observational epidemiology;offspring;Particulate Matter;Pathway interactions;Pattern;Phagocytosis;pharmacologic;Pollution;Pre-Clinical Model;Predisposition;Pregnancy;pregnant;prenatal;prevent;Prevention;Prevention strategy;Process;Public Health;Regulatory Pathway;repetitive behavior;Reporting;Research;response;Risk;Sampling;Seasons;sex;Sex Differences;Social Interaction;Solid;Soot;Source;Synapses;Testing;Time;transcriptome;transcriptome sequencing;Translating;United States;Wildfire;Woman

PROJECT_TITLE: Combined environmental exposures and neurodevelopment disorders

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Machine Learning and Artificial Intelligence;Malaria;Prevention;Rare Diseases;Social Determinants of Health;Vector-Borne Diseases

ORG_CITY: IRVINE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: RELEVANCE The invasion and rapid spread of Anopheles stephensi in Africa pose great threats to malaria control and elimination in Africa. Control of An. stephensi in Africa currently relies primarily on larviciding, yet the location of habitats, particularly in urban areas, and the optimal time for larviciding are not yet known. This project will provide policy makers with this critical information to guide the effective design and implementation of larviciding programs.

PI_NAMEs: ZHOU, GUOFA  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Address;Adult;Aedes;Affect;Africa;Africa South of the Sahara;African;Age;Anopheles Genus;Area;Behavior;Biological;Biological Factors;Bite;Cities;Collaborations;Collection;Country;Culicidae;Data;data integration;density;design;Detection;Development;Disease Outbreaks;disorder control;Djibouti;Eastern Africa;Ecology;Environmental Risk Factor;Ethiopia;Ethiopian;experimental study;Food;food resource;Geography;Government;Habitats;Health;Horns;Insecticides;Intervention;Invaded;Kenya;Knowledge;larval control;Location;Machine Learning;machine learning method;machine learning model;Malaria;Maps;Methods;microbial;Modeling;mortality;Mosquito-borne infectious disease;multiscale data;Nigeria;Outcome;Parasites;Plasmodium falciparum;Plasmodium vivax;Policy Maker;Population;Population Dynamics;Population Growth;predictive modeling;Predisposition;Productivity;programs;Regulation;remote sensing;reproductive;Rest;rural area;Scientist;Seasons;Site;socioeconomics;Somalia;Source;Spatial Distribution;Study models;Sudan;Surveys;survivorship;Techniques;Testing;Time;Uncertainty;urban area;urban setting;Validation;vector;vector competence;Visual;Western Africa;Work;World Health Organization

PROJECT_TITLE: Larval Ecology of Invasive Anopheles stephensi in Ethiopia

STUDY_SECTION: TVZ

STUDY_SECTION_NAME: Transmission of Vector-Borne and Zoonotic Diseases Study Section [TVZ]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Digestive Diseases - (Peptic Ulcer);Infectious Diseases

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: PROJECT NARRATIVE Chronic infection with the human pathogen, Helicobacter pylori (Hp), is a major risk factor for several important diseases, including stomach cancer. The only protein toxin secreted from Hp, which is called the Vacuolating Cytotoxin, assists the bacterium in establishing infection within the stomach and contributes to the severity of gastric disease. Studies to identify the detailed mechanism by which this toxin interacts with and enters gastric cells will, not only provide additional insights into how Hp infection leads to gastric disease but will also provide necessary clues for future work to mitigate the effects of the toxin during bacterial infection within the human stomach, using structural-based drug design, building upon knowledge obtained from completing the studies proposed in this application.

PI_NAMEs: BLANKE, STEVEN R. (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Address;Alanine;Alleles;Atrophic;Autophagocytosis;Bacteria;Bacterial Infections;Bacterial Toxins;Binding;Binding Proteins;Binding Sites;Biochemical;Biogenesis;Cancer Etiology;Cell membrane;Cell surface;Cell Surface Receptors;Cells;Cessation of life;Characteristics;chronic infection;Collaborations;Cytotoxin;Development;Disease;disorder risk;Drug Design;Duodenal Ulcer;epidemiology study;Epithelial Cells;Epitopes;Exotoxins;experimental study;Future;Gastric Adenocarcinoma;Gastritis;Genetic Polymorphism;genetic variant;Gland;Glycosphingolipids;Helicobacter Infections;Helicobacter pylori;Heparitin Sulfate;high risk;Human;human pathogen;Immune response;Immunosuppression;In Vitro;Incidence;Infection;inhibitor;insight;interest;Intestinal Metaplasia;Intoxication;Ion Channel;Knowledge;Laboratories;malignant stomach neoplasm;Mammalian Cell;Membrane;Membrane Lipids;Metaplasia;mimetics;mitochondrial dysfunction;Modeling;Molecular;molecular dynamics;mouse model;Mucous Membrane;Muscarinic M1 Receptor;novel;pathogen;Pathology;Peptic Ulcer;Phosphorylcholine;Phylogenetic Analysis;Population;premalignant;Productivity;Property;Protein Tyrosine Phosphatase;Proteins;receptor;receptor binding;Receptor Cell;receptor protein tyrosine phosphatase-beta;Reporting;Risk;Risk Factors;Role;segregation;Sequence Alignment;Severities;Side;Site;Specificity;Sphingolipids;Sphingomyelins;Stomach;Stomach Diseases;Structure;Surface;Time;tissue tropism;Toxin;Tropism;Tryptophan;Vacuole;Variant;Virulence Factors;Work

PROJECT_TITLE: The Helicobacter pylori VacA Receptor Binding Site

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: WORCESTER

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: WORCESTER POLYTECHNIC INSTITUTE

PHR: Prenatal screening secures the earliest window of opportunity for proper management and treatment of congenital heart diseases; however, both false positive and false negative diagnoses frequently occur primarily because of the low resolution of the fetal imaging technique. Personalized flow modeling has been widely used to augment medical imaging modalities for adult and pediatric heart diseases; however, no models have been developed for fetal circulation. This project will develop the first validated computational flow model for fetal circulation and focus on the aorta, which could contribute to shifting the translational paradigm for understanding hemodynamics and etiology, improving diagnosis and prognosis, and examining the safety and efficacy of therapies for coarctation of the aorta and other congenital heart diseases.

PI_NAMEs: WEI, ZHENGLUN ALAN (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: 4D MRI;Acceleration;Accounting;Adult;Anatomy;Anxiety;Aorta;Aortic coarctation;Blood flow;Cardiac;cardiac magnetic resonance imaging;Cardiogenic Shock;Cardiovascular system;Cause of Death;Child;Childhood;Chronic Disease;Circulation;clinical practice;Computer Models;Congenital Abnormality;congenital heart abnormality;Counseling;critical congenital heart disease;Data;Diagnosis;Dimensions;Doppler Ultrasound;Ductus Arteriosus;Echocardiography;effective therapy;Etiology;experience;Family;Fathers;fetal;Fetal Heart;Fetal Research;Fetus;Foundations;Future;Goals;Heart Diseases;hemodynamics;Image;imaging modality;Imaging Techniques;improved;Infant;Knowledge;Link;Liquid substance;Live Birth;Magnetic Resonance Imaging;Medical Imaging;Modeling;Motion;Newborn Infant;novel;Obstruction;Outcome;Pathogenesis;Patients;Perinatal;personalized medicine;Phase;Pilot Projects;Postnatal Care;Pregnant Women;prenatal;prenatal testing;Prevention;Prognosis;Property;Protocols documentation;Radial;reconstruction;Recurrence;repaired;Research;Resolution;routine practice;Safety;screening;Secure;Series;shear stress;Slice;Solid;spatiotemporal;Structure;Techniques;Time;tool;translational study;Treatment Efficacy;Validation;Work

PROJECT_TITLE: A Novel Personalized Flow Modeling Paradigm for Fetal Aorta and Its Validation with Fetal Cardiac MRI

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Aging;Bioengineering;Data Science;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Macular Degeneration;Networking and Information Technology R&D (NITRD);Neurodegenerative;Prevention

ORG_CITY: CHARLOTTE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF NORTH CAROLINA CHARLOTTE

ORG_STATE: NC

PHR: Public Health Relevance Statement Advanced age-related macular degeneration (AMD) in the form of geographic atrophy (GA) is a retinal disease that is a leading cause of severe vision loss worldwide. We are developing artificial intelligence (AI) based techniques to collaboratively build GA risk models using multi-institutional data cohorts with a diverse sub-population. Distributed deep learning will be used to build robust models to improve clinical management of AMD.

PI_NAMEs: ALAM, MINHAJ NUR  (contact)

PROGRAM_OFFICER_NAME: LE, JIMMY TOAN

PROJECT_TERMS: Age related macular degeneration;Algorithms;Artificial Intelligence;artificial intelligence model;Blindness;Chicago;Classification;Clinical;Clinical Data;Clinical Management;cohort;Consensus;cost;Data;Data Analyses;Data Compromising;Data Reporting;Data Set;data sharing;deep learning;deep learning model;Democracy;Diagnosis;Diagnostic;diverse data;Drops;Early Diagnosis;Early treatment;Elderly;Environment;federated learning;firewall;follow-up;geographic atrophy;Goals;Growth;heterogenous data;high risk;Illinois;Image;improved;innovation;insight;Institution;Intellectual Property;Intervention;Learning;learning network;machine learning prediction;Metadata;Methods;model building;model generalizability;Modeling;Multimodal Imaging;multimodality;novel;Optical Coherence Tomography;Outcome;Pathway interactions;patient privacy;Patients;Performance;Population;predictive modeling;predictive tools;prevent;Privacy;prognostic;prognostic performance;prognostic tool;progression risk;Protocols documentation;public health relevance;repository;Research;Retinal Diseases;Risk;Risk Assessment;risk prediction;risk prediction model;screening;Secure;self supervised learning;social;success;Taiwan;Techniques;Testing;Therapeutic Intervention;Training;training data;Treatment outcome;trend;Universities;Visit;Visual impairment;Work

PROJECT_TITLE: Domain-adaptive federated learning to develop machine learning models for predicting incident and progression of geographic atrophy

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (01)]


NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Neurosciences;Rehabilitation;Stroke

ORG_CITY: AUSTIN

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: PROJECT NARRATIVE Maximizing the therapeutic effects of transcranial magnetic stimulation (TMS) interventions on poststroke motor function requires that these interventions be delivered during poststroke brain states during which TMS best activates the residual corticospinal tract and enhances its neural transmission. In this project, we will use machine learning to identify personalized EEG brain states that predict strong and weak residual corticospinal tract activation in chronic stroke survivors (Aim 1) and develop a real-time EEG analysis algorithm that accurately delivers TMS during personalized EEG brain states in neurotypical adults (Aim 2). Results will provide the mechanistic rationale, methodological foundation, and preliminary data for future personalized brain state- dependent TMS interventions that target the residual corticospinal tract after stroke.

PI_NAMEs: HUSSAIN, SARA J (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Adult;Affect;Algorithmic Analysis;Algorithms;Brain;Brain Injuries;chronic stroke;Communication;Corticospinal Tracts;Data;Dependence;design;Dorsal;Electroencephalography;Exhibits;Exploratory/Developmental Grant;Foundations;Frequencies;Future;Goals;Hand;hand dysfunction;Hand functions;Human;improved;individual variation;Intervention;large scale data;Lesion;Machine Learning;machine learning classifier;machine learning framework;Methodology;Methods;Motor;motor deficit;Motor Evoked Potentials;Motor Neurons;Movement;Muscle;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;novel;Output;Paresis;Pathway interactions;Pattern;Performance;personalized predictions;post stroke;Recovery;recruit;Reproducibility;Residual state;response;Rest;Stimulus;Stroke;stroke intervention;stroke survivor;Structure;Synaptic Transmission;Techniques;Therapeutic Effect;Time;Transcranial magnetic stimulation;transmission process;virtual;Work

PROJECT_TITLE: Developing real-time personalized TMS to target residual corticospinal connections after stroke

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: WINSTON-SALEM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Acute myeloid leukemia (AML) is an aggressive cancer of the bone marrow and outcomes in non-Hispanic blacks are worse than in non-Hispanic whites. The reasons for the difference in outcomes is not known and the lack of preclinical models from non-Hispanic blacks makes studying the problem difficult. The ultimate goal of this project is to generate new preclinical models of AML from cells derived from non-Hispanic blacks to better understand the differences in response to therapy.

PI_NAMEs: PARDEE, TIMOTHY SEBASTIAN (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Acute leukemia;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adult;Azacitidine;bead chip;Biochemical;Biochemical Pathway;Biological;Biological Models;Biopsy;biracial;black patient;Black Populations;Bone Marrow;Bone Marrow Cells;cancer genetics;cancer health disparity;Caucasians;CD34 gene;Cell Communication;Cell Line;Cell Therapy;Cells;Clinical;Clinical Trials;Collaborations;Core Facility;Cytarabine;Data;Data Set;Daunorubicin;design;Development;Disease remission;Disparity;DNA cassette;DNA Damage;drug development;efficacious treatment;Ensure;Equity;Event;Future;Generations;Genes;Genetic;Goals;health disparity;Hybrids;Immune;inhibitor;innovation;Insertional Mutagenesis;Investigational Therapies;Knowledge;Malignant Bone Marrow Neoplasm;Malignant Neoplasms;Menin;Mitochondria;Modeling;Mus;Mutate;Mutation;myeloid leukemia cell;Myeloproliferative disease;Nature;Not Hispanic or Latino;novel strategies;novel therapeutics;NPM1 gene;nucleofection;Organoids;Outcome;Patient Participation;Patients;personalized care;pre-clinical;Pre-Clinical Model;precursor cell;Prognosis;prognostic;Proliferating;promoter;Property;Race;racial difference;racial diversity;Relapse;Research Personnel;Resistance;Resource Sharing;Resources;response;Risk;risk stratification;Sampling;Simian virus 40;Sleeping Beauty;Source;Stromal Cells;survival disparity;Survival Rate;System;Testing;The Cancer Genome Atlas;Titrations;treatment response;treatment stratification;tumor;tumor microenvironment;Work

PROJECT_TITLE: Developing Acute Myeloid Leukemia Models with Diverse Ancestral Origins

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Cardiovascular;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Uncontrolled blood vessel growth and inflammation in the eye lead to vision loss in premature babies, diabetes, and age-related macular degeneration. Identifying alternative targets for regulating retinal damage will enable the development of complementary or alternative therapeutic strategies. The proposed work will investigate an understudied atypical proinflammatory pathway in the eye and test the capacity of innovative strategies to reduce disease-causing responses.

PI_NAMEs: GRIMSEY, NEIL J (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: 3-Dimensional;Acceleration;Adaptor Signaling Protein;adenovirus mediated delivery;Age related macular degeneration;Amyloidosis;angiogenesis;Angiogenesis Inhibitors;Anti-Inflammatory Agents;Automobile Driving;bevacizumab;Blindness;Blood Vessels;Bypass;C57BL/6 Mouse;Cells;Cellular Stress;cytokine;Data;Dependovirus;Dermal;Development;Diabetes Mellitus;Diabetic Retinopathy;Disease;DNA Sequence Alteration;Edema;Endothelial Cells;Endothelium;Eye;G-Protein-Coupled Receptors;Gene Expression;Generations;Genetic;Goals;Growth;Healthcare;heart damage;Homeostasis;Human;Immune;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injury;innovation;Intrabody;Ischemia;Knowledge;Lead;Macrophage Activation;Microscopy;Modality;Modeling;Molecular;Mus;Myocardial Ischemia;nanobodies;neovascular;neovascularization;novel therapeutics;Oxidative Stress;Oxygen;p38 Mitogen Activated Protein Kinase;Pathologic;Pathway interactions;Patients;Penetration;Peptides;Physiological;Play;Premature Infant;prevent;Production;recruit;Regulation;Research;Resolution;response;Retina;retinal damage;Retinal Diseases;Retinal Neovascularization;Retinopathy of Prematurity;Role;Satellite Viruses;Signal Transduction;spheroids;Testing;Therapeutic;therapeutic target;therapeutically effective;transcriptome sequencing;treatment strategy;tumor growth;Vascular Diseases;Vascular Endothelial Cell;vascular inflammation;vasculogenesis;Viral;Virus Diseases;Work

PROJECT_TITLE: Atypical Pathological Signaling as a Target to Regulate Retinal Vasculopathies

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE The proposed studies are relevant to public health as they may provide new proof-of-concept evidence for the role of Staphylococcus aureus in aspirin-exacerbated respiratory disease (AERD). These studies would char- acterize the role of eicosanoids and mast cells in AERD that may lay the groundwork for discovery of novel diagnostic markers and therapeutic strategies to target S. aureus or mast cells to improve health outcomes in AERD patients.

PI_NAMEs: JERSCHOW, ELINA  (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Acute;airway remodeling;Anabolism;Anti-Bacterial Agents;Antibacterial Response;Antigens;arachidonate;Arachidonic Acids;Aspirin;aspirin-exacerbated respiratory disease;Asthma;Bacteria;Cell Culture Techniques;Cell Line;Cell Separation;Cells;Characteristics;chemokine;chronic rhinosinusitis;Clinical;cyclooxygenase 1;Data;Development;Diagnosis;diagnostic biomarker;Diagnostic tests;differential expression;eicosanoid metabolism;Eicosanoid Production;Eicosanoids;Environmental Risk Factor;Excision;Exhibits;Exotoxins;experimental study;Exposure to;Functional disorder;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Growth;Health;Human;Immune Evasion;Immune response;improved;In Vitro;Infection;Inflammation;Inflammatory;inhibitor;Integrin alpha Chains;Invaded;Laboratories;Leukotriene E4;Leukotrienes;Life;mast cell;Measures;Metabolism;Modeling;Morbidity - disease rate;Nasal Polyps;neutrophil;Non-Steroidal Anti-Inflammatory Agents;Nose;novel diagnostics;Operative Surgical Procedures;Outcome;pathogen;Pathogenesis;Pathway interactions;Patients;pharmacologic;polyposis;Polyps;Population;Production;programs;Prostaglandin D2;Public Health;Publishing;Reaction;Recurrence;Research;respiratory;response;Role;Serine Protease;single-cell RNA sequencing;Sinus;Staphylococcus aureus;STAT4 protein;Syndrome;Testing;Therapeutic;tissue/cell culture;Tissues;Up-Regulation

PROJECT_TITLE: Staphylococcus aureus and eicosanoid dysregulation as drivers of inflammation in aspirin-exacerbated respiratory disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-F (57)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_DEPT: PHYSIOLOGY

PHR: Project Narrative: The proposed research is relevant to public health because defective uterine environment during early preg- nancy is a key factor for two important public health problems, infertility and early pregnancy loss. This pro- posal aims to decipher how uterine immune environment is regulated by uterine epithelial estrogen receptor α during early pregnancy to make the uterus conducive for sperm passage and preimplantation embryos. The understanding of mechanisms in regulating uterine immune environment during early pregnancy is critical for developing diagnostic and therapeutic approaches to detect and treat infertility and early pregnancy loss asso- ciated with defective uterine environment.

PI_NAMEs: WATFORD, WENDY T;YE, XIAOQIN  (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: adaptive immunity;Allogenic;Area;Biological;blastocyst;Cells;Chemotactic Factors;Clinical;Coupled;cytokine;Data;Diagnostic;early pregnancy;early pregnancy loss;Embryo;Embryonic Development;Endometrial;Ensure;Environment;Epithelial Cells;Epithelium;ESR1 gene;Estrogens;Event;Fertility;Fertilization;fitness;Flow Cytometry;Genes;Goals;Health;Immune;Immunity;Immunohistochemistry;Immunologic Factors;immunological status;Immunologics;Impairment;Infertility;Inflammation;Inflammatory;Injections;Innate Immune Response;insight;Interleukin-1 beta;Knowledge;male;Mammalian Oviducts;Mediating;migration;Molecular;Mothers;mouse model;mRNA sequencing;Mus;National Institute of Child Health and Human Development;natural Blastocyst Implantation;neutrophil;Neutrophil Infiltration;novel;Outcome;Partner in relationship;Pathway Analysis;Pathway interactions;Pregnancy;preimplantation;Proestrus;Progesterone;Public Health;Readiness;recruit;Research;Research Priority;Role;Sampling;Seminal fluid;Signal Transduction;spatiotemporal;sperm cell;Testing;Therapeutic;Up-Regulation;Uterus;Woman;Work

PROJECT_TITLE: Uterine epithelial ERα regulates preimplantation uterine immunity and sperm fitness

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE The use of checkpoint inhibitor drugs has altered the therapy of cancer, leading to cures in untreatable diseases. However, by reinvigorating the immune system, these drugs are also associated with immune- mediated adverse events that resemble spontaneous autoimmunity, are poorly understood, and limit the use of potentially lifesaving treatments. The goal of this proposal is to improve our understanding the biology of the T cells that cause these adverse events.

PI_NAMEs: LAUFER, TERRI M. (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Address;Adverse event;Aftercare;anti-PD-1;Antigen Targeting;Antigenic Specificity;Antigens;Arthritis;Autoantibodies;Autoantigens;Autoimmune;autoimmune toxicity;Autoimmunity;autoreactivity;Biological Assay;Biology;bone;cancer therapy;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Physiology;Cell surface;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;checkpoint inhibition;Clonal Expansion;cohort;Cohort Analysis;Colitis;Cross Reactions;cross reactivity;Cross-Sectional Studies;CTLA4 gene;Data;Development;Disease;Dose;Endocrine System Diseases;exome;experimental study;Gene Expression Profile;Genetic Transcription;Goals;Immune;immune activation;immune checkpoint blockade;Immune checkpoint inhibitor;Immune system;immune-related adverse events;immunopathology;Immunophenotyping;Immunotherapy;improved;Incidence;Individual;Inflammatory Arthritis;inhibitor therapy;Knowledge;Lead;Life;longitudinal design;Lymphocyte;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Monitor;Morbidity - disease rate;multiple omics;Nature;Non-Small-Cell Lung Carcinoma;Oncology;Pathogenicity;Pathway Analysis;Patients;Pattern;PD-1 blockade;Peptides;Peripheral;Phage ImmunoPrecipitation Sequencing;Pharmaceutical Preparations;Phenotype;Population;prediction algorithm;predictive marker;programmed cell death protein 1;prospective;Prospective cohort;Pulmonary Inflammation;receptor;response;screening;Site;Smoking Status;Specificity;T cell receptor repertoire sequencing;T cell response;T-Cell Activation;T-Lymphocyte;Therapeutic;Tissues;transcriptome;tumor;Tumor Antigens;Tumor Burden;tumor microenvironment

PROJECT_TITLE: Mechanisms of CD4 autoreactivity after checkpoint inhibition

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Lupus

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative Although the presence of antibodies to dsDNA is a unifying feature among patients with systemic lupus erythematosus (SLE), not all anti-dsDNA antibodies are pathogenic. The proposed studies will investigate a novel mechanism to explain the origin and pathogenic heterogeneity of anti-dsDNA antibodies in SLE.

PI_NAMEs: ANDRADE, FELIPE  (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Activities of Daily Living;Address;Affinity;anti-dsDNA antibodies;Antibodies;Antibody Formation;Antigen Targeting;Antigens;Autoantibodies;Autoantibody binding;Autoantigens;Autoimmune Diseases;autoreactivity;Basic Amino Acids;Binding;Clinical;cross reactivity;Data;design;Diagnosis;Diagnostic;Disease;ds-DNA;endonuclease;Flare;Foundations;Genetic;Germ Lines;Goals;Heterogeneity;Human;Immune;immunogenic;Immunoglobulin Somatic Hypermutation;insight;interest;Measures;Mediating;Modeling;Molecular;Monoclonal Antibodies;Mus;Mutate;Nephritis;novel;novel therapeutics;Outcome;Pathogenesis;Pathogenicity;Patients;Peptides;prevent;Process;Property;Protein Precursors;Proteins;Proteome;Research Personnel;response;Serology;Specificity;Systemic Lupus Erythematosus;targeted treatment;Testing;Tissues;tool;Work

PROJECT_TITLE: The antigenic origin of anti-dsDNA antibodies in SLE

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project narrative: This project will image the fiber pathways that form the circuitry of the human brain with cutting-edge diffusion MRI and optical imaging technologies ex vivo. We will use the microscopic-scale optical imaging data to guide the development of more accurate tractography algorithms for reconstructing brain pathways from mesoscopic-scale diffusion MRI. As the latter is the only technique that can image the circuitry of the human brain non-invasively, improving the accuracy of methods for analyzing diffusion MRI data will benefit the wide range of neurological and psychiatric applications where this circuitry is implicated.

PI_NAMEs: YENDIKI, ANASTASIA  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: 3-Dimensional;Acceleration;algorithm development;Algorithms;Anatomy;Architecture;Area;Atlases;Attention;Autopsy;Axon;Brain;brain circuitry;Brain imaging;brain pathway;Catalogs;Classification;Communities;Complex;Computer software;connectome;Data;data acquisition;data analysis pipeline;data quality;Data Set;deep learning;Development;Diffusion;Diffusion Magnetic Resonance Imaging;Engineering;Ensure;Evaluation;Failure;Fiber;Frequencies;Funding;Geometry;Goals;Histologic;Human;human imaging;Image;imaging modality;Imaging technology;improved;in vivo;indexing;insight;Institution;interest;Literature;Magnetic Resonance Imaging;Maps;Measurement;Measures;Methods;Microscopic;Microscopy;Modeling;Multimodal Imaging;multimodality;multiscale data;neural circuit;Neurologic;next generation;novel;open source;Optical Coherence Tomography;optical imaging;Optics;Pathway interactions;pre-clinical;Preparation;Protocols documentation;reconstruction;Research;Resolution;Sampling;Scanning;Scheme;Signal Transduction;Software Tools;Stains;Structural Models;Structure;success;Techniques;Technology;Testing;Time;tractography;Training;training data;Validation;validation studies;Variant;white matter;Work

PROJECT_TITLE: Mapping human neurocircuitry across scales with diffusion MRI and optical imaging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-Q (81)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: Boulder

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: Project Narrative  Whereas innate responses to stress provide many important physiological mechanisms to help cope with the demands of daily challenges, the prolonged or repeated exposure to stress is associated with several psychopathologies and physical disorders. The current application seeks new information about a brain region, the rostral region of the posterior hypothalamic nucleus, that is centrally situated to integrate multiple sources of information, coordinate multiple stress-related responses, and that may significantly contribute to reduce the impact of repeated stress. This novel hypothesis could provide a breakthrough in the understanding of this normal, but ill-defined, stress adaptive process, which could suggest new avenues for the treatment of mood and anxiety disorders.

PI_NAMEs: CAMPEAU, SERGE  (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Affect;Affective;Amygdaloid structure;Anatomy;Anxiety Disorders;Behavioral;behavioral response;biological adaptation to stress;Brain;Brain region;Calcium;Cardiovascular system;Catecholamines;Cell Nucleus;Cells;Chronic stress;Clinical;Cognitive;cognitive function;Complex;coping;Decision Making;design;designer receptors exclusively activated by designer drugs;Development;Disease;Elements;Emotional;Etiology;experience;Exposure to;Female;Fiber;gamma-Aminobutyric Acid;Gender;Genetic;Genetic Techniques;Genetic Transcription;Glucocorticoids;Glutamates;habituation;Human;Hypothalamic structure;Impairment;Incidence;indexing;Individual;Laboratories;Lead;Limbic System;male;Mediating;Memory;Methods;Modality;Modification;Mood Disorders;Moods;nerve supply;neural;neural circuit;neuroadaptation;neuromechanism;Neurosecretory Systems;Neurotransmitters;Nodal;novel;novel therapeutics;Organism;Photometry;Physiological;Population;Positioning Attribute;Posterior Hypothalamus;postsynaptic;Precipitation;presynaptic;Prevalence;Process;promoter;Prosencephalon;psychologic;Psychopathology;Rattus;Reaction;Recurrence;Regulation;Reporting;response;Risk;Role;sensor;Sensory;sex;Sex Differences;Signal Transduction;Source;Specific qualifier value;Specificity;Stress;stress reduction;stressor;Structure of paraventricular nucleus of thalamus;System;Techniques;Testing;Transcriptional Regulation;Viral

PROJECT_TITLE: Posterior Hypothalamic Contribution to Stress Adaptation

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: DALLAS

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative While a large proportion of early-onset glaucoma cases have a genetic basis, only 12 genes have been described so far for primary forms of the disease, compared to hundreds for retinal dystrophies. We have recently shown that a powerful and unbiased state-of-the-science Forward Genetics approach can be used to identify novel gene-phenotype associations that are crucial to retinal health, and we propose now to exploit this strategy to identify and characterize genes, and pathways involved in the development of early-onset glaucoma. Our long-term goal is to leverage research results from our Forward Genetics studies to develop better clinical screening tests for genes associated with early-onset glaucoma, and to discover novel diagnostic and therapeutic targets.

PI_NAMEs: UFRET-VINCENTY, RAFAEL  (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Adolescent;Adult;Age;Age Years;Aqueous Humor;Blindness;causal variant;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Co-Immunoprecipitations;Collaborations;Complex;complex biological systems;Computer software;Conceptions;CRISPR/Cas technology;Data;Databases;Defect;Development;Diagnosis;Disease;Early Diagnosis;early onset;Early treatment;Eligibility Determination;Ensure;Ethylnitrosourea;experimental study;forward genetics;Functional disorder;Funding;Fundus;ganglion cell;gene discovery;Generations;Genes;Genetic;genetic approach;genetic association;Genetic Models;genetic panel test;genetic pedigree;Genetic study;Genome;Genotype;Glaucoma;Goals;Health;Image;imaging system;improved;Individual;interest;Investigation;Knowledge;Legal Blindness;legally blind;Life;Link;Longitudinal Studies;Maintenance;Maps;Mass Spectrum Analysis;Measurement;Measures;Meiosis;Methods;Modality;Molecular;Monitor;mouse genome;Mus;Mutagenesis;Mutagens;mutant;Mutation;Nature;Nerve Fibers;new therapeutic target;Nitrosourea Compounds;novel;novel diagnostics;novel strategies;novel therapeutics;Open-Angle Glaucoma;Optical Coherence Tomography;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Physiologic Intraocular Pressure;Pilot Projects;Predisposition;primary congenital glaucoma;Primary Open Angle Glaucoma;prospective;Proteins;Proteomics;Protocols documentation;Regulation;Reporting;Research;Retina;Retinal Degeneration;Retinal Dystrophy;Retinal Ganglion Cells;retinal imaging;Scanning;Science;screening;single-cell RNA sequencing;Spottings;System;Techniques;Testing;Thick;Thinness;Time;Transgenic Mice;Work

PROJECT_TITLE: Using Forward Genetics to Explore the Genetics and Mechanisms of Early Onset Glaucoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-T (02)]


PHR: Project Narrative Topoisomerase II (Top2B) plays essential roles in the transcription of developmentally regulated genes and synaptic activity-dependent genes. Top2B mutations at the catalytic core are related to neurodevelopmental delay and autism spectrum disorder, while at the C-terminal domain (CTD) cause hearing loss. Our proposed research will investigate how the mutation reported in patients as well as the phosphorylation induced by neuronal activity, modulate the function of Top2B.

PI_NAMEs: DELINT RAMIREZ, ILSE  (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: Address;Affect;Auditory;autism spectrum disorder;Biological Assay;C-terminal;Calcineurin;calcineurin phosphatase;Calcium;Catalytic Domain;Cell Differentiation process;Cell Fractionation;Cell Line;Cells;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Cochlea;Complex;Confocal Microscopy;Core Facility;CRISPR/Cas technology;Cross-Linking Reagents;crosslink;Development;Disease;disuccinimidyl suberate;DNA;Early Gene Transcriptions;Etoposide;experimental study;Fright;Gamma-H2AX;Ganglia;Gene Expression;Genes;Genetic Transcription;Genome;genome editing;genome-wide;Genomics;Hair Cells;hearing impairment;Hippocampus;Human;Immediate-Early Genes;immunocytochemistry;Immunoprecipitation;Impairment;In Vitro;in vitro activity;in vitro Assay;Incubated;Induced Mutation;Induced Neurons;insight;Knowledge;Learning;Link;Mass Spectrum Analysis;Mediating;Mus;mutant;Mutation;N-Methyl-D-Aspartate Receptors;neuroblast;Neurons;Nucleotides;Patients;Phosphorylation;Play;promoter;Property;Protein Dephosphorylation;protein protein interaction;Proteins;Proteomics;Protocols documentation;Publishing;Regulation;Relaxation;Reporting;Research;response;Role;Running;Sampling;Sensorineural Hearing Loss;Sensory Hair;Serine;Serum;spiral ganglion;Standardization;Stimulus;Structure;Synapses;Testing;Topoisomerase;Topoisomerase II;Trypsin;Western Blotting

PROJECT_TITLE: Regulation of Topoisomerase 2 Beta by phosphorylation at the C-Terminal domain

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Biotechnology;Infectious Diseases;Prevention;Rehabilitation

ORG_CITY: CLEMSON

ORG_DEPT: CHEMISTRY

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: Program Director/Principal Investigator (Last, First, Middle): Anker, Jeffrey N. Project Narrative This research project develops an implanted X-ray visualized immunosensor to noninvasively measure local antigen concentrations through tissue. This platform technology has a wide range of preclinical research and clinical diagnostics/monitoring applications. To show proof of principle, we will develop an infection biomarker sensor (α-defensin) and test in both a human cadaveric prosthetic hip model and a live rat peritoneal dialysis model. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

PI_NAMEs: ANKER, JEFFREY N (contact)

PROGRAM_OFFICER_NAME: FALCONE, JESSICA

PROJECT_TERMS: Acrylamides;Acrylates;Acylation;Affect;alpha-Defensins;Anatomy;Animal Model;Animals;Antibiotic Therapy;Antibiotics;Antibodies;Antigens;Area;aspirate;Autopsy;Bacteria;Binding;Biological Markers;Biomedical Research;Biopsy;blind;Blood;Buffers;Cadaver;Calibration;Catheters;Cell Culture Techniques;Cessation of life;Chemicals;Clinical;clinical diagnostics;clinical practice;Clip;Contracts;cost;crosslink;Debridement;design;Development;Devices;Diameter;Early Diagnosis;Emergency Medicine;Emergency Situation;Ensure;Environment;Equilibrium;Fluoroscopy;Focal Infection;follow-up;Friction;Gel;Goals;Growth;Health;Health Care Costs;Hip Prosthesis;Hip region structure;Hospitals;Human;Hydrogels;ideation;Image;Immune system;Implant;implantable device;implantation;improved;In Situ;In Vitro;in vivo;Incubated;Infection;Inflammation;Interobserver Variability;Intervention;Ions;Irrigation;joint infection;Kinetics;Life Expectancy;Liquid substance;Measurement;Measures;Mechanics;Medical Device;medical implant;meter;Methods;Microbial Biofilms;Modeling;Monitor;Morbidity - disease rate;mortality;Motion;neutrophil;Nosocomial Infections;novel;Operative Surgical Procedures;Orthopedics;Pain;Patients;Peritoneal;Peritoneal Dialysis;Peritoneal Fluid;Peritonitis;Pharmaceutical Preparations;Physiological;Physiology;polyacrylamide;polyacrylamide hydrogels;Positioning Attribute;pre-clinical research;Principal Investigator;Procedures;programs;Prosthesis;prototype;Quality of life;radiological imaging;radiologist;rapid detection;Rattus;Reaction;Reaction Time;Reporting;Research;Research Project Grants;response;Roentgen Rays;screening;sensor;Sepsis;Shapes;sheep model;Solvents;specific biomarkers;standard of care;success;Swelling;Synovial Fluid;Systemic infection;Tantalum;Technology;technology platform;Temperature;Testing;Time;Tissues;tool;Tube;Variant;Visit;Visualization;Work;X ray visualization;X-Ray Medical Imaging

PROJECT_TITLE: X-ray Visualized Immunosensor (X-VIS)

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

PHR: Project Narrative SARS-CoV-2 infection during pregnancy is associated with obstetric complications and placental abnormalities, but little is known about the resulting long-term impact on the neurodevelopment health of children. The proposed work will characterize early childhood neurodevelopmental outcomes following maternal pregnancy-associated SARS-CoV-2 infection in the context of placental abnormalities, both broadly and in key areas of self-regulation and communication. This research would answer an important clinical and public health question that can 1) lead to near-term improvement in developmental care and 2) inform future mechanistic and therapeutics research to reduce harm from SARS-CoV-2 infection during pregnancy.

PI_NAMEs: MITHAL, LEENA BHATTACHARYA (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 2019-nCoV;Address;Adverse effects;Affect;Archives;Area;biobank;Biometry;Birth;Blood Vessels;Brain;Caring;Child;Child Development;Child Health;Childhood;Clinical;Code;cohort;Collaborations;Communication;comparison control;Complex;congenital infection;Counseling;COVID-19;COVID-19 complications;COVID-19 pandemic effects;COVID-19 susceptibility;cytokine;Data;Development;Diagnosis;Disease;early childhood;Environment;Evaluation;Evolution;Exposure to;Faculty;follow-up;Functional disorder;Future;Generations;Harm Reduction;Health;high risk;Histopathology;Immune;improved;in utero;Individual;infancy;Infant;Infant Development;Infant Health;infant outcome;Infection;Inflammation;Inflammatory;Informal Social Control;Injury;innovation;insight;Knowledge;Language;Lead;Learning;Lesion;Literature;Longitudinal cohort;Longitudinal Studies;male;Mediator;Mental Health;Methods;Monitor;Mothers;Motor;neurodevelopment;new therapeutic target;Newborn Infant;novel;novel therapeutics;obstetrical complication;Outcome;pandemic disease;Parents;pathogen;Pathology;Pathway interactions;Patients;Perinatal Infection;Persons;Placenta;post SARS-CoV-2 infection;Pre-Eclampsia;Pregnancy;pregnant;Pregnant Women;Premature Birth;prenatal;psychologic;Public Health;Reporting;Research;Risk;risk stratification;Sampling;SARS-CoV-2 B.1.617.2;SARS-CoV-2 infection;Science;sex;Specimen;stillbirth;Subgroup;Surveys;Therapeutic Research;vaccine access;Variant;video visit;Viral;Work

PROJECT_TITLE: Characterizing the early childhood neurodevelopmental impact of infants exposed to maternal SARS-CoV-2 infection during pregnancy

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Digestive Diseases;Genetics;Liver Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: In vitro stem cell derived human organoids face challenges to faithfully recapitulate human biology due to limited efficiency and robustness during engineering as well as immaturity of their developmental status. In this proposal, we will use genetically programmed organoids to study cellular decisions and devise strategies to engineer tissue cell composition and function. Our approach will generate a new paradigm for engineering stem cell derived multicellular system.

PI_NAMEs: EBRAHIMKHANI, MO REZA (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Adult;Advanced Development;Animal Experiments;Behavior;Biochemical;Biological Process;Biology;Cell Differentiation process;Cell Separation;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Competence;Complement;Complex;computational pipelines;computational platform;Computer Models;Data;Dependence;design;Development;Disease;Drug Metabolic Detoxication;Endoderm;engineered stem cells;Engineering;Epigenetic Process;Exhibits;Face;Future;GATA6 transcription factor;Gene Expression;Generations;Genes;Genetic;Genetic Engineering;genetic technology;Genetic Transcription;Genotype;Growth Factor;Hepatic;Hepatocyte;Human;Human Biology;Human Engineering;human induced pluripotent stem cells;human pluripotent stem cell;human stem cells;human tissue;In Vitro;in vivo;induced pluripotent stem cell;inducible gene expression;Libraries;Liver;Maps;Mesoderm;Mesoderm Cell;Metabolism;Methodology;Methods;Modeling;Molecular;next generation;Organ;Organ Model;Organ Transplantation;Organogenesis;Organoids;Outcome;Outcome Assessment;Performance;Pharmaceutical Preparations;Phenotype;Physiology;Play;Population;Process;progenitor;programs;Proliferating;rational design;reconstitution;Regenerative Medicine;Reproducibility;self organization;Shapes;stem cell derived tissues;stem cell organoids;stem cells;success;synthetic biology;System;Systems Biology;Technology;Testing;Tissue Engineering;Tissues;transcription factor;Variant

PROJECT_TITLE: Integration of Systems and Synthetic Biology to Advance Development of Human Tissues In Vitro

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Nanotechnology

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: PROJECT NARRATIVE Ulcerative Colitis (UC) and Crohn’s disease (CD), the two major types of inflammatory bowel disease (IBD), are chronic diseases with recurrent symptoms and significant morbidity. This research project is highly relevant to public health as a multidisciplinary investigation of novel nanoparticle-encapsulated BRD4 inhibitors that may be used as efficient nanomedicine therapeutics for IBD and associated diseases (e.g., colitis-associated colorectal cancer), and thus to the NIH mission of developing new medications and fundamental knowledge that will help to lengthen life and reduce the burdens of illness.

PI_NAMEs: RYTTING, ERIK ;TIAN, BING  (contact);ZHOU, JIA

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Acute;Adherens Junction;Animal Disease Models;Animals;Apoptotic;Area;Area Under Curve;Binding;Biological Availability;Bromodomain;Bromodomains and extra-terminal domain inhibitor;burden of illness;Cell Death;Cell Line;Cells;Cellular biology;Chronic;Chronic Disease;Colitis;Colitis associated colorectal cancer;Colon;Colonic inflammation;Confocal Microscopy;Crohn's disease;cytotoxic;cytotoxicity;Data;design;Development;dextran sulfate sodium induced colitis;Disease;disease model;Dose;Drug Delivery Systems;drug development;Drug Kinetics;effective therapy;effector T cell;Encapsulated;Epigenetic Process;Epithelial Cells;epithelial injury;Epithelium;Evaluation;FDA approved;Fibroblasts;Foundations;Generations;Genes;Goals;Half-Life;Harvest;Histologic;Histology;Human;Immune;improved;In Vitro;in vivo;Incubated;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;inhibitor;Investigation;Knowledge;Legal patent;Life;lymph nodes;Macrophage;Measurement;Measures;Medical;Mesenchymal;Mission;Modeling;Molecular Biology;Morbidity - disease rate;mouse model;Mucositis;Mucous Membrane;multidisciplinary;Mus;nano;nanoencapsulated;nanoformulation;nanomedicine;nanoparticle;nanoparticle delivery;nanotoxicity;novel;novel therapeutics;Oral;Oral Administration;Outcome;parenteral administration;Pathologic;Patients;Peripheral Blood Mononuclear Cell;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Pilot Projects;Polymers;promoter;Proteins;Public Health;Quantitative Reverse Transcriptase PCR;Recurrence;Research Project Grants;Resistance;response;Safety;safety study;Sampling;Sentinel;side effect;Signal Transduction;Site;Solid;Symptoms;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Tight Junctions;Tissues;TNF gene;Toxic effect;Ulcerative Colitis;United States National Institutes of Health;Western Blotting

PROJECT_TITLE: Nanoparticle-encapsulated Epigenetic Inhibitors for Treatment of Inflammatory Bowel Diseases

STUDY_SECTION: DBDT

STUDY_SECTION_NAME: Drug and Biologic Disposition and Toxicity Study Section[DBDT]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Liver Disease

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE As in many other cancers, during colorectal cancer progression, the protein and sugar-rich scaffolding—known as the extracellular matrix—around the tumor cells stiffens, leading to worse outcomes; this increase in stiffness is particularly notable in metastatic tumors. How these stiffening events lead to increased cell division, movement and signaling is not well understood. Our proposal seeks to look at how matrix stiffness impacts the RhoA pathway, a known mediator of mechanical tension that is often disrupted in colon cancer, via a novel gel material that can both harden and soften on demand with the goal of deciphering the role of matrix mechanics and how they may be targeted in future treatment regimes.

PI_NAMEs: DEFOREST, COLE A (contact);GRADY, WILLIAM MALLORY

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: 3-Dimensional;Actins;antifibrotic treatment;Atomic Force Microscopy;Attenuated;Back;Binding;Biochemical;Biocompatible Materials;Biological Assay;biomaterial compatibility;Biophysics;Biosensor;cancer cell;Cancer Etiology;Cell division;Cells;Cessation of life;Chemistry;Colon;colon cancer patients;Colon Carcinoma;Colorectal Cancer;colorectal cancer progression;Crosslinker;design;Development;Diagnosis;Disease Progression;Disputes;Disseminated Malignant Neoplasm;dosage;Elasticity;Encapsulated;Environment;Enzymes;ethylene glycol;Event;Excision;Exposure to;extracellular;Extracellular Matrix;Feedback;Future;Gel;Goals;Growth;Hydrogels;In Situ;in vivo;in vivo Model;innovation;insight;Integrin Binding;Integrins;Lead;Length;lentivirally transduced;Lesion;Ligands;Ligation;Light;light microscopy;Liver;Malignant Neoplasms;Measures;Mechanics;Mediating;Mediator;Memory;metastatic colorectal;Metastatic Neoplasm to the Liver;Modeling;Monitor;Morphology;Movement;Myosin Light Chains;Neoplasm Metastasis;neoplastic cell;novel;Operative Surgical Procedures;Organoids;Outcome;Oximes;Pathogenesis;Pathway interactions;Patients;Peptides;pharmacologic;Phenotype;Phosphorylation;photolysis;Physiological;Primary Lesion;Primary Neoplasm;Proliferating;protein aminoacid sequence;Proteins;Psychological reinforcement;Recovery;recruit;Reporting;Resolution;response;rho;rhotekin;Role;Route;Sampling;scaffold;Scaffolding Protein;Signal Transduction;Site;sortase;Spectrum Analysis;Stimulus;sugar;Survival Rate;Suspensions;System;Time;Tissues;Treatment outcome;tumor;tumor progression;Tumor Tissue;tumorigenesis;United States;Visualization;Western Blotting;Work

PROJECT_TITLE: On-Demand Modulation of Extracellular Matrix Mechanics for Studying RhoA Activation in Primary and Metastatic Colorectal Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-X (83)]


ORG_CITY: NOTRE DAME

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: Project Narrative  The health outcomes of using a prosthesis and orthosis depend on the physical interface between compliant human tissue and the rigid or padded structures of the device. There is a fundamental gap in knowledge about how to characterize interface pressures outside the clinic and the laboratory without expert sensor calibration and placement. This project will enable the accurate measurement of interface pressure for more than 16 continuous hours without expert supervision to provide quantifiable data for the design of comfortable prosthetic sockets and orthoses.

PI_NAMEs: BOLÍVAR-NIETO, EDGAR ALBERTO (contact)

PROGRAM_OFFICER_NAME: LASH, TIFFANI BAILEY

PROJECT_TERMS: Acceleration;Algorithms;Amputation;biomechanical model;Biomechanics;Calibration;Cell model;Clinic;clinically significant;Clothing;cost;Data;design;Devices;Diabetes Mellitus;Distal;Doctor of Philosophy;Electronics;Esthesia;Event;exosuit;Exposure to;Feasibility Studies;Feedback;Frustration;Gait;Goals;Health;Hour;Human body;human subject;human tissue;Hypesthesia;improved;innovation;instrumentation;kinematics;Knowledge;Laboratories;laboratory equipment;Laws;limb amputation;Limb structure;Location;Long-Term Effects;Lower Extremity;Measurement;Measures;Mechanics;Methodology;Methods;Monitor;operation;Orthotic Devices;Outcome;Persons;Population;portability;pressure;pressure sensor;prevent;Process;Property;Prosthesis;prosthetic socket;Protocols documentation;residual limb;Residual state;Risk;Robotics;sensor;side effect;Source;Spinal cord injury;Structure;Supervision;Technology;Textiles;theories;Ulcer;wearable device;Wheelchair user

PROJECT_TITLE: Towards Physical-Interface Pressure Monitoring Outside the Laboratory with Lower-Limb Electronic Clothing and Robust Optimization

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Rhythm  and  timing  are  essential  to  successful  spoken  communication  but  difficulties  in  rhythm  and  social  communication skills are frequently observed in autism. Building on our prior findings demonstrating sensitivity  to speech rhythms as manifest in entrainment of speech rate in conversing typically developing individuals, here  we  assess  rhythm  skills  as  a  mechanism  underlying  speech  rate  entrainment  in  autistic  individuals,  the  moderating  role  of  social  agreement,  and  their  relationship  with  conversational  outcomes.  This  research  will  provide  a  foundation  for  linking  rhythm,  social  factors,  and  communication  with  the  potential  to  impact  frameworks for understanding communication and interactional success in autism.

PI_NAMEs: LENSE, MIRIAM  (contact);WATSON, DUANE G

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TITLE: Rhythm, social information, and conversational entrainment in autism

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Genetics;Mental Health;Neurosciences

ORG_CITY: ANN ARBOR

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The proposed project aims to determine the roles of enzymes that regulate histone methylation in stabilizing the neuronal network. Impaired methyl histone regulation characterizes many human neurodevelopmental disorders such as intellectual disability and autism, in which the neuronal network is less stable. Thus, obtained knowledge through the proposed research will provide a foundation for an evidence-based approach for future therapeutic intervention of these conditions.

PI_NAMEs: IWASE, SHIGEKI  (contact);SUTTON, MICHAEL MARK ALEXANDER

PROJECT_TERMS: Address;Area;autism spectrum disorder;Behavior;Behavioral;Biology;Brain;Buffers;cell type;cellular imaging;ChIP-seq;Chromatin;Clinical;clinically relevant;Cognitive deficits;cognitive development;cognitive function;Development;Electrophysiology (science);Enzyme Interaction;Enzymes;Equilibrium;evidence base;Excitatory Synapse;Family;Foundations;Future;Gene Deletion;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;Genetic;genetic approach;Genetic study;Genetic Transcription;Goals;Hippocampus;Histone H3;histone methylation;Histones;Hour;Human;Hyperactivity;Impairment;in vivo;Individual;Intellectual functioning disability;knock-down;Knowledge;Link;Lysine;Maps;Measures;Methylation;Methyltransferase;MLL gene;Molecular;neural;neural circuit;neural network;Neurodevelopmental Disorder;Neuronal Plasticity;Neurons;neurotransmission;Neurotransmitters;novel;Output;Pathologic;Pathway interactions;Pattern;Phenotype;Play;Process;programs;Regulation;Research;response;RNA interference screen;Role;scale up;sensory input;Signal Transduction;Structure;Synapses;synaptic function;Synaptic plasticity;System;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Tissues;Transcriptional Regulation;transcriptome sequencing;Work;Yin-Yang

PROJECT_TITLE: Dissecting Histone H3K4 Methylation Enzymes in Neuroplasticity

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The proposed study aims to develop novel strategies for generating Adeno Associated Virus (AAV)-based tools that can target specific cell types in the retina. The AAV tools generated in this work can advance retinal studies and benefit gene therapy-based treatment of retinal diseases.

PI_NAMEs: WANG, SUI  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Adult;Amacrine Cells;Automobile Driving;Binding;Binding Sites;cell assembly;Cell Density;cell type;Cells;Chromatin;Communities;Complex;cost effective;Dependovirus;design;Development;Disease;DNA;Elements;Enhancers;Ensure;FDA approved;Future;ganglion cell;Gene Expression;gene therapy;Genome;in vivo;Inherited;Label;Methods;Molecular;Morphology;Mus;Neurons;novel;novel strategies;Nucleosomes;Outcome;Pattern;Population;promoter;Publishing;Research;response;Retina;Retinal Diseases;Retinal Dystrophy;screening;Secure;single cell ATAC-seq;single-cell RNA sequencing;Specificity;Testing;Tissues;tool;transcription factor;Untranslated RNA;Validation;Work

PROJECT_TITLE: Novel strategies for developing AAV tools targeting specific cell types in mammalian retina


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Diabetes;Neurodegenerative;Neurosciences;Nutrition;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: NARRATIVE A comprehensive assessment of dietary and serum levels of Advanced Glycation End products (AGEs) in older adults with type 2 diabetes will determine if AGEs are associated with incident dementia, cognitive decline, and neuropathological indices of cerebrovascular and Alzheimer's disease (AD). Identifying modifiable metabolites associated with impaired cognition, has potential to lead to new treatments that may decrease the growing burden of impaired cognition in T2D elderly and in the aging community as a whole.

PI_NAMEs: SCHNAIDER BEERI, MICHAL  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, DALLAS

PROJECT_TERMS: 3D ultrasound;Advanced Glycosylation End Products;Affect;Aging;aging population;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid;Arterial Fatty Streak;Biological;Blood;Blood brain barrier dysfunction;Blood Vessels;blood-brain barrier disruption;blood-brain barrier function;Brain;brain health;Brain Pathology;Carotid Artery Plaques;Cell model;Cells;Cephalic;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;cerebrovascular reactivity;Chronic;Clinical Trials;Clinical Trials Design;Cognition;Cognitive;cognitive testing;Collaborations;Communities;comparison control;contrast enhanced;Data;Dementia;dementia burden;dementia risk;Diabetes Mellitus;Diagnosis;Diet;dietary;Dietary Assessment;dietary restriction;Elderly;endothelial dysfunction;Endothelium;Enrollment;Glucose;Goals;gray matter;Health Priorities;Health Services;high risk;Hippocampus;Human;human old age (65+);Impaired cognition;Impairment;indexing;Individual;Inflammation;Insulin Resistance;Israel;Knowledge;late life;Link;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Mediating;Medical center;medical schools;Memory;Mus;Nerve Degeneration;neuropathology;non-demented;Non-Insulin-Dependent Diabetes Mellitus;novel;older adult;Outcome;Participant;Pathogenesis;Pathology;Pharmaceutical Preparations;Positron-Emission Tomography;Questionnaires;Registries;Research;Serum;Testing;therapy development;White Matter Hyperintensity

PROJECT_TITLE: Systemic and dietary advanced glycation end products in type 2 diabetes-related cognitive decline and incident dementia: effects on Alzheimer's pathology and cerebrovascular disease

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Human Genome;Huntington's Disease;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSURGERY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: This proposal aims to develop an effective neuroprotective treatment for Huntington’s disease by targeting DNA methylation, a critical epigenetic mechanism implicated in the dysregulation of gene expression in this disease. If successful, the proposed research will provide important preclinical evidence for a new class of disease-modifying treatment for Huntington’s disease and potentially for other neurological disorders in which aberrant DNA methylation is implicated, and thus this research is relevant to public health.

PI_NAMEs: YANO, HIROKO  (contact);ZHAO, GUOYAN

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Aberrant DNA Methylation;analog;Animal Behavior;Applications Grants;Atrophic;Attenuated;Automobile Driving;Behavior;behavioral phenotyping;behavioral study;Bioinformatics;Brain;brain cell;Brain Diseases;Brain region;cell type;Cells;Characteristics;Clinical;Cognitive deficits;Collaborations;Complex;Corpus striatum structure;Data;Decitabine;demethylation;Deoxycytidine;Development;Disease;disease model;disease phenotype;Disease Progression;DNA;DNA Methylation;DNA Methylation Inhibition;DNA methylation profiling;DNA Modification Methylases;DNA Sequence Alteration;dosage;Drug Screening;Drug Targeting;effective therapy;effectiveness evaluation;Ensure;epigenetic drug;Epigenetic Process;Exhibits;experimental study;Foundations;Functional disorder;Gene Abnormality;Gene Expression;Gene Mutation;Gene Targeting;Genes;Genetic Transcription;genome-wide;Goals;Human;Huntington Disease;Huntington gene;In Vitro;in vivo;Individual;individual response;inhibitor;innovation;insight;Measurement;Mediating;Methylation;methylation pattern;Modeling;Molecular;Molecular Abnormality;motor disorder;mouse model;Mus;mutant;Nature;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neuroglia;neuron loss;Neuronal Dysfunction;Neurons;neuropathology;neuroprotection;Neuroprotective Agents;neurotoxicity;novel;Osmosis;Pathogenesis;Pathology;Pathway interactions;Pharmaceutical Preparations;Play;polyglutamine;pre-clinical;Proteins;Public Health;Pump;Regimen;Research;response;restoration;Role;single cell genomics;single cell technology;single nucleus RNA-sequencing;Testing;Therapeutic;therapeutic candidate;Therapeutic Intervention;therapeutic target;Tissues;Toxic effect;Transcription Alteration;Treatment Effectiveness;treatment optimization;treatment strategy;Variant

PROJECT_TITLE: Therapeutic targeting of DNA methyltransferases in Huntington's disease

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Estrogen;Immunotherapy;Women's Health Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: We will test the hypothesis that SIM2s and ER regulate SEMA7A expression in a reciprocal manner to promote ER+ breast tumor resistance to endocrine therapy and progression via activation cell survival pathways and immunosuppressive signaling. Mechanisms uncovered by our studies will provide impetus for clinical trials targeting SIM2s and SEMA7A aimed at improving outcomes for thousands of breast cancer patients annually.

PI_NAMEs: BORGES, VIRGINIA F.;LYONS, TRACI  (contact);PORTER, WESTON W

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: Address;Binding;Breast Cancer Cell;Breast Cancer Patient;breast cancer progression;CDK4 gene;Cell Cycle Progression;Cell Survival;Cells;Cessation of life;Childbirth;Clinical Trials;clinically relevant;Cohort Studies;Combined Modality Therapy;Data;Disease;epithelial to mesenchymal transition;ESR1 gene;Estrogen receptor positive;Estrogen Therapy;Exhibits;FOXP3 gene;Frequencies;Gene Expression;Genetic Transcription;Goals;Growth;high risk;hormone therapy;Immunity;Immunocompetent;Immunosuppression;Immunotherapy;improved outcome;inhibitor;Invaded;link protein;Malignant Breast Neoplasm;Mammary Neoplasms;Mediating;Membrane;Messenger RNA;Metastatic/Recurrent;Mind;Monoclonal Antibodies;mouse model;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;overexpression;paracrine;Pathway interactions;patient derived xenograft model;patient population;Patients;PIK3CG gene;postpartum breast cancer;preclinical study;Predictive Factor;predictive marker;Pregnancy;prevent;programmed cell death ligand 1;programmed cell death protein 1;progression marker;progression risk;promoter;protein expression;Protein Isoforms;Proto-Oncogene Proteins c-akt;Publications;Recurrence;Regulation;Relapse;relapse prediction;Repression;Resistance;Role;Semaphorins;Signal Transduction;Tamoxifen;targeted treatment;Testing;The Cancer Genome Atlas;therapy resistant;Transcription Repressor;tumor;tumor progression;Tumor Promotion;Up-Regulation;Woman;women's diagnosis;young woman

PROJECT_TITLE: A SIM2s/SEMA7A Switch Drives ER+ Breast Cancer Progression

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]