NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Estrogen;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Women's Health Research

ORG_NAME: FORDHAM UNIVERSITY

PHR: Project Narrative Women of reproductive age experience rhythmic changes in sex hormone levels over the monthly menstrual cycles. These hormonal changes impact female brain structure and function and are likely to confer female- specific risks for neuropsychiatric disorders such as anxiety and depression, which are more prevalent in women than in men. This project uses an animal model to reveal molecular (epigenetic) mechanisms through which sex hormones dynamically affect female brain and behavior, facilitating the development of sex-specific treatments for mental disorders.

PI_NAMEs: KUNDAKOVIC, MARIJA  (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: 3-Dimensional;Address;Affect;Age;Animal Model;Animals;Anxiety;anxiety-related behavior;ATAC-seq;Automobile Driving;Behavior;Binding Sites;Bioinformatics;Biological Assay;Brain;candidate identification;Cell Nucleus;Cells;ChIP-seq;Chromatin;Chromatin Loop;chromatin remodeling;Complement;Data;design;Development;Diestrus;Disease;disorder risk;Disproportionately impacts women;Distant;Drops;emotion regulation;emotional behavior;Enhancers;Epigenetic Process;epigenetic regulation;epigenomics;estrogenic;Estrogens;Estrous Cycle;Etiology;Event;Exhibits;experience;experimental study;Female;Fright;Gene Expression;Gene Expression Regulation;Gene Family;Genes;genetic manipulation;Genetic Transcription;genomic locus;Genomics;Goals;Gonadal Steroid Hormones;Hi-C;Hippocampus;histone modification;Hormonal;Hormonal Change;Hormone Receptor;Hormones;In Situ Hybridization;in vivo;Life;Link;male;Maps;Mediating;men;Menstrual cycle;Mental Depression;Mental disorders;Methods;Modeling;Molecular;mouse model;Mus;Nature;Neurons;neuropsychiatric disorder;neuropsychiatry;Ovarian Cycles;Ovariectomy;overexpression;Perimenopause;Periodicity;Phase;Phenotype;Physiological;Postpartum Period;Proestrus;programs;promoter;Regulation;Regulatory Element;reproductive;Reproductive Periods;Research;Risk;RNA;Role;sex;sex cycle;single nucleus RNA-sequencing;Specificity;Structure;synaptic function;Testing;transcription factor;transcriptome sequencing;transcriptomics;Variant;Woman;Women's prevalence;women's treatment

PROJECT_TITLE: Epigenetic regulation of brain and behavior by the estrous cycle

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: CLEVELAND

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Currently, more than 15 million people in North America suffer from age-related macular degeneration (AMD), and the overall prevalence of this disease is projected to increase by over 50% by the end of 2020. The pathogenesis of AMD causes irreversible blindness, and there are currently no effective treatment options for the most common (nonexudative or “dry”) form of the disease. Therefore, this proposal aims to open new therapeutic avenues for the treatment of AMD, by identifying novel phosphodiesterase-modulating compounds and characterizing the signaling pathways through which they exert their cytoprotective effects in the context of retinal degeneration.

PI_NAMEs: LUU, JENNINGS C (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Adverse effects;Affect;Age related macular degeneration;Aging;Apoptotic;Binding;Biology;Blindness;Caffeine;Cardiovascular Physiology;Cell Death;Cell Survival;cell type;Chronic;Clinical;combat;Combined Modality Therapy;Computer Assisted;Consumption;Cyclic AMP;Cyclic GMP;Cyclic Nucleotides;Cytoprotection;Data;Development;Disease;Dose;drug action;Drug Design;Drug Industry;Drug Targeting;Dryness;effective therapy;Engineering;Enzymes;Erectile dysfunction;Exclusion;Exhibits;Functional disorder;Goals;Human;Human body;Immune system;immunoregulation;improved;in silico;in vivo;inhibitor;inhibitor therapy;innovation;insight;Intervention;Investments;Knockout Mice;Lead;Learning;Light;Link;Maintenance;Memory;Metabolism;Methods;Modeling;Molecular;molecular dynamics;mouse model;Neurobiology;North America;novel;novel therapeutics;Pathogenesis;Pathologic;Pathway interactions;PDE2 phosphodiesterase;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Pharmacology;Phosphodiesterase Inhibitors;phosphoric diester hydrolase;Photoreceptors;Phototoxicity;Phototransduction;Physiological;Physiological Processes;Play;preservation;Prevalence;prevent;Preventive therapy;Process;protective effect;Protein Isoforms;Recording of previous events;repaired;Reproduction;response;Retina;Retinal Degeneration;RNA Splicing;Role;screening;Second Messenger Systems;side effect;Signal Pathway;Signal Transduction;Signaling Molecule;Specificity;Stress;synergism;System;Systems Biology;targeted agent;Therapeutic Agents;Therapeutic Effect;Tissues;Treatment Efficacy;Validation;Variant;Viagra;Vision

PROJECT_TITLE: Identification of novel phosphodiesterase (PDE)-modulating compounds and characterization of associated cytoprotective pathways in lightdamagedretina


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hepatitis;Liver Cancer;Liver Disease;Prevention;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative Extracellular vesicles (EVs) are present in circulation at a relatively early stage of hepatocellular carcinoma (HCC). The long-term goal of this R01 proposal is to develop a new HCC EV digital scoring assay for non- invasively detecting early-stage HCC. The successful development of the proposed assay will be rapidly translatable and reproducible, enabling a sensitive and biologically relevant EV-based quantitative assay for detecting HCC at an early stage.

PI_NAMEs: ZHU, YAZHEN  (contact)

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Abdomen;Address;AFP gene;Alcoholic Liver Diseases;Antibodies;assay development;Bioinformatics;Biological;Biological Assay;Biological Markers;Biology;Biometry;Cancer Etiology;cell type;Cessation of life;Chemistry;Circulation;Cirrhosis;Clinical;cohort;Couples;detection assay;Development;Devices;Diagnosis;Diagnostic;diagnostic value;digital;Disulfides;Early Diagnosis;Ensure;Etiology;Evaluation;Exhibits;extracellular vesicles;Filtration;Goals;Hepatitis B;Hepatitis C;hepatocellular carcinoma cell line;Image;in-vitro diagnostics;Infection;innovation;Joints;Liver;Liver Cirrhosis;Mediating;Medical center;Messenger RNA;Methods;Microfluidics;Minor;Modality;Modeling;molecular pathology;Motivation;nanomaterials;Nanostructures;neoplastic cell;non-alcoholic fatty liver disease;Non-Invasive Detection;Oncology;Operative Surgical Procedures;particle;Patients;Performance;Phospholipids;Plasma;Population;Precipitation;Primary carcinoma of the liver cells;Quantitative Evaluations;Regimen;Reporting;Reproducibility;Research;Research Personnel;Reverse Transcription;Risk;Risk Factors;Sampling;Secondary to;Sensitivity and Specificity;Serum;Site;Solid Neoplasm;Specific qualifier value;Specificity;Specimen;standard of care;Surface;Techniques;Technology;Training;tumor heterogeneity;Tumor-Derived;Ultracentrifugation;Ultrasonography;Validation;vesicular release

PROJECT_TITLE: Extracellular Vesicle-Based Digital Scoring Assay for Detecting Early-stage Hepatocellular Carcinoma

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE The microbiota of cancer patients is correlated with their response to immunotherapy drugs, but the mechanisms of specific commensal bacteria strains have not been elucidated and limit their translation into new therapeutics. The Hang laboratory recently discovered that beneficial Enterococci strains have unique peptidoglycan composition and remodeling enzymes. These exciting findings reveal fundamental microbiota mechanisms in cancer immunotherapy and afford new opportunities to engineer probiotic bacteria and synthesize immunomodulatory metabolite analogs to improve cancer immunotherapy.

PI_NAMEs: HANG, HOWARD C (contact)

PROGRAM_OFFICER_NAME: XI, DAN

PROJECT_TERMS: analog;Animal Model;anti-CTLA4;anti-PD-1/PD-L1;anti-PD-L1 therapy;anti-PD1 therapy;Attenuated;Bacteria;cancer immunotherapy;Cancer Patient;cancer therapy;Cell Wall;Cells;checkpoint therapy;Chemicals;clinical efficacy;commensal bacteria;Disease;Disseminated Malignant Neoplasm;Endopeptidases;Engineered Probiotics;Engineering;enteric infection;enteric pathogen;Enterococcus;Enterococcus durans;Enterococcus faecium;Enzymes;Growth;gut inflammation;Health;host microbiota;Human;human model;Immune;Immune checkpoint inhibitor;Immune response;Immune signaling;Immunity;immunoregulation;Immunotherapy;improved;in vivo;Individual;intestinal barrier;Laboratories;lactic acid bacteria;Large-Scale Sequencing;Link;Livestock;Malignant neoplasm of lung;Malignant Neoplasms;Melanoma;Metastatic Melanoma;microbiota;microbiota composition;Molecular;mouse model;novel;novel therapeutic intervention;novel therapeutics;Pathway interactions;patient response;Patients;Pattern recognition receptor;Peptidoglycan;pet animal;Pharmaceutical Preparations;Population;Probiotics;protective factors;Renal Carcinoma;resident commensals;Resistance;response;Role;Signal Pathway;small molecule;Therapeutic;Therapeutic Agents;therapy outcome;Translating;Translations;Work

PROJECT_TITLE: Translation of commensal bacteria mechanism for immunotherapy

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention

ORG_CITY: Columbus

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Narrative Flu infection claims thousands of lives every year despite the currently available treatments and vaccinations. We have identified a host cellular protein that facilitates viral replication and contributes flu severity. The proposed studies will elucidate the role of this host protein in viral replication, which can lead to new therapeutic targets to reduce influenza A virus (IAV) infection and disease progression in humans.

PI_NAMEs: MEBRATU, YOHANNES AFEWORK (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Affect;airway epithelium;Anti-viral Agents;Appearance;BCL2 gene;BIK gene;Binding;bronchial epithelium;Cancer Patient;Cell Physiology;Cells;Cessation of life;Clinical Data;cohort;Complex;cost;CRISPR/Cas technology;Data;design;differentiation in vitro;Disease;Disease Management;Disease Progression;Dose;drug resistance development;Drug Targeting;economic cost;Epidemic;Epithelial Cells;Exhibits;flu;Foundations;Frequencies;Future;Genetic;Genetic Polymorphism;genetic risk factor;genome integrity;Goals;Human;human disease;Impairment;improved;in vivo;individualized prevention;Infection;Infection Control;Influenza;Influenza A virus;influenza A virus nucleoprotein;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H3N2 Subtype;influenza infection;inhibitor;Integration Host Factors;Life;Link;Lung;Mediating;Modeling;Mus;mutant;Mutation;new therapeutic target;novel;novel strategies;Nucleoproteins;Pathway interactions;Peptides;personalized medicine;Persons;Pneumonia;Predisposition;Prevention;Process;protein expression;Proteins;Public Health;Pulmonary Inflammation;Pulmonary Pathology;recombinant virus;respiratory;Respiratory Disease;Ribonucleoproteins;Risk;Risk Factors;risk variant;Role;Seasons;Severities;Severity of illness;Single Nucleotide Polymorphism;Site;small molecule;stem;Survival Rate;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;Time;Vaccination;Variant;Viral;Viral Drug Resistance;Viral Genome;Viral Load result;Viral Proteins;Virus;Virus Assembly;Virus Diseases;Virus Replication;virus testing;Wild Type Mouse

PROJECT_TITLE: The role of Bik in the replication and severity of influenza A virus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-N(03)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: Narrative We will develop and disseminate innovative new technology for measuring precise 3D kinematics in freely moving animals over long time-periods. Our proposed experimental platform will illuminate how natural behaviors are organized and help us understand how they are controlled by the nervous system, and how this control goes awry in disease. The technological leap made possible by this grant will catalyze a host of studies on the neural mechanisms underlying motor control, learning, and mental disorders, and thus help in the discovery of new diagnostic and therapeutic approaches for afflicted patients.

PI_NAMEs: OLVECZKY, BENCE P (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 3-Dimensional;Acceleration;Adopted;Anatomy;Animal Behavior;Animal Model;Animals;appendage;Behavior;Behavioral;Benchmarking;Biological Models;Biomedical Research;Brain;Callithrix;Cephalometry;Communities;Complex;computer science;convolutional neural network;cost;Data;Data Set;deep neural network;Deer Mouse;design;Disease;Ensure;Environment;expectation;experimental study;flexibility;Grant;Hand;Human;Image;Image Analysis;improved;Individual;innovation;kinematics;Label;Learning;Learning Disorders;Lighting;Limb structure;Logic;Longitudinal Studies;Machine Learning;Measurement;Measures;Mental disorders;Methods;millimeter;model organism;Modeling;Monitor;Monkeys;Motion;motor control;Movement;Mus;Nervous System;Nervous System Physiology;neural;neural network;Neurologic Deficit;neuromechanism;new technology;novel diagnostics;novel therapeutic intervention;Output;Patients;Performance;Positioning Attribute;Posture;Process;programs;Rattus;Research;Research Personnel;Resolution;Rodent;scale up;skeletal;spatiotemporal;Subject Headings;System;Techniques;Technology;Testing;Time;Training;training data;Work

PROJECT_TITLE: A system for long-term high-resolution 3D tracking of movement kinematics in freely behaving animals

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: BALTIMORE

ORG_DEPT: PATHOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE Traumatic brain injury (TBI) is a major concern in our communities, with an annual incidence of clinically significant TBI at 2-3 millions. The commonest neuropathology encountered across various types and degrees of severity of TBI is diffuse or traumatic axonal injury, i.e. deformation of axons caused by the mechanical forces of injury. Subsequent to this, many axons turn on a self-destruction program that takes apart brain connections and systems. Here we propose that blocking molecules that drive this program saves axons and protects brain connections and functions.

PI_NAMEs: KOLIATSOS, VASSILIS E (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Affect;Atrophic;Axon;axon injury;axonal degeneration;axonopathy;Behavior;behavior test;Brain;Cells;Cessation of life;Clinical Trials;clinically significant;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Complement;Complementary DNA;conditional knockout;Corticospinal Tracts;CRISPR/Cas technology;designer receptors exclusively activated by designer drugs;Development;Diffuse;Dominant-Negative Mutation;experimental study;Future;Genetic;genetic technology;genome editing;Goals;Hour;Impairment;Incidence;indexing;inhibitor;injured;Injury;Intervention;JNK-activating protein kinase;jun Oncogene;kinase inhibitor;Knock-out;Knockout Mice;Laboratories;Leucine Zippers;mechanical force;member;metabolomics;Mitogen-Activated Protein Kinases;Modeling;Molecular;Molecular Genetics;Molecular Probes;Molecular Profiling;Molecular Target;Morphology;Motor;motor deficit;Motor Skills;Nerve Degeneration;Neuroanatomy;Neurons;neuropathology;Neuropathy;neuroprotection;neurotransmission;novel therapeutics;Outcome;Pathway interactions;pharmacologic;Phosphotransferases;preservation;prevent;Prevention;Prognosis;programs;repaired;Research;Resolution;response to injury;Role;Safety;Secondary to;Severities;Signal Pathway;Signal Transduction;small molecule;small molecule inhibitor;Spinal;Sterility;synergism;System;Testing;Therapeutic Agents;therapy design;tool;Tracer;Translating;Trauma;Traumatic Brain Injury;Visualization;Wallerian Degeneration;white matter;Work

PROJECT_TITLE: Traumatic Axonopathy in the CNS as Wallerian degeneration

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

PHR: Project Narrative We propose to use transgenic Drosophila melanogaster (fruit flies) and mice, to define the mechanisms by which post-translational modifications to actin modulate thin filament and cardiac contractile regulation. We will also scrutinize new fly models of actin and troponin-T-based cardiomyopathies to determine the molecular defects that drive distinct forms of adverse myocardial remodeling. Finally, we will ascertain if specific actin post- translational modifications improve or exacerbate heart muscle diseases caused by an array of mutations in the contractile machinery.

PI_NAMEs: CAMMARATO, ANTHONY  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Acetylation;Actins;Actomyosin;Affect;Amino Acids;Animal Model;Automobile Driving;Binding;Binding Sites;Biological Assay;Biological Models;biophysical analysis;Cardiac;cardiac muscle disease;Cardiomyopathies;Characteristics;Charge;Communication;Complex;Cryoelectron Microscopy;Defect;Development;Dilated Cardiomyopathy;Disease;disease model;disease-causing mutation;Drosophila genus;Drosophila melanogaster;Electrostatics;Elements;Ensure;Environmental Risk Factor;F-Actin;fly;Funding;Generations;Genetic;Genotype;Goals;Growth;Heart;heart function;Human;Hypertrophic Cardiomyopathy;image reconstruction;Impairment;improved;in silico;In Vitro;in vivo;Individual;insight;interfacial;Laboratories;Lead;Lesion;Location;Lysine;Mechanics;Mediating;mimetics;Modeling;Modification;Molecular;Motility;mouse model;Movement;Mus;Muscle;Muscle function;Mutation;Myocardial;Myocardial dysfunction;Myosin ATPase;novel;Organ;Pathogenesis;Pathologic;Pathology;Performance;Phenotype;Physiological;Positioning Attribute;Post-Translational Protein Processing;prevent;Process;Production;Property;Proteins;Recombinants;Regulation;Relaxation;response;Rest;Restrictive Cardiomyopathy;Running;Severities;Signal Induction;Slide;Speed;Structure;Surface;Techniques;Testing;Thick;Thin Filament;Time;Tissues;tool;Transgenic Organisms;transmission process;Tropomyosin;Troponin;Troponin T;Variant;Ventricular Remodeling;Work

PROJECT_TITLE: PATHOGENESIS AND IN VIVO SUPPRESSION OF THIN FILAMENT-BASED CARDIOMYOPATHIES

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-B(02)]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Diabetes;Eye Disease and Disorders of Vision;Neurosciences;Prevention

ORG_CITY: BOSTON

ORG_NAME: JOSLIN DIABETES CENTER

PHR: PROJECT NARRATIVE In studies involving the Medalist cohort, composed of people with insulin-dependent diabetes for ≥50 years, as well as their donated retinal tissues, we have identified a retina-specific protein, retinol binding protein 3 (RBP3), which can neutralize the toxic effects of hyperglycemia and diabetes on the retinal tissues and blood vessels. In this application, we will evaluate whether retinal and serum RBP3 levels correlate with severity of diabetic retinopathy in a wide range of patients, and investigate the regulation of its expression and its protective mechanisms on retinal cells. These findings have identified RBP3 as a potential new therapeutic agent for diabetic retinopathy.

PI_NAMEs: KING, GEORGE L (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Adverse effects;Affect;Antibodies;Autopsy;Binding;Biological Assay;Blindness;Blood capillaries;Blood Vessels;Cell Line;Cell Surface Proteins;Cells;Chronic;Clinical Research Protocols;Clinical Trials;cohort;Data;Developed Countries;Development;Diabetes Mellitus;diabetic;diabetic rat;Diabetic Retinopathy;Down-Regulation;Electroretinography;Embryo;Endothelial Cells;Enzyme-Linked Immunosorbent Assay;Eye;Finland;FRAP1 gene;Gene Targeting;Glucose;glucose uptake;glycemic control;Glycosylated hemoglobin A;Grant;Hyperglycemia;in vivo;Individual;Inflammatory;inhibitor;Injections;Insulin-Dependent Diabetes Mellitus;Interleukin-6;interstitial retinol-binding protein;Intervention;Intervention Studies;KDR gene;laser photocoagulation;Length;Lentivirus;macular edema;Mass Spectrum Analysis;Medicine;Microvascular Dysfunction;Modality;mRNA Expression;Muller's cell;new therapeutic target;non-diabetic;novel;novel therapeutic intervention;novel therapeutics;Nuclear;overexpression;Paper;Pathway interactions;Patients;Persons;Photoreceptors;Plasma;Population Study;potential biomarker;prevent;proliferative diabetic retinopathy;promoter;prospective;protective factors;protein activation;protein expression;Protein Isoforms;protein kinase C-delta;Proteins;Proteomics;Protocols documentation;Recombinants;Regulation;Reporting;Retina;Retinal Photoreceptors;Retinol Binding Proteins;Rhodopsin;Rodent;Science;Serum;Severities;SLC2A1 gene;Structure;Structure-Activity Relationship;subretinal injection;Therapeutic Agents;Therapeutic Intervention;therapeutic target;Tissues;Toxic effect;transcription factor;Transgenes;translational medicine;Translational Research;type I and type II diabetes;Validation;Vascular Endothelial Growth Factors;Vascular Permeabilities

PROJECT_TITLE: Characterization of Retinoid-Binding Protein 3 (RBP3): A Protective Factor Against Diabetic Retinopathy Identified in People with Extreme Diabetes Duration

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


ORG_CITY: MINNEAPOLIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Neuroplasticity is an essential characteristic of the respiratory neural control system; imparting flexibility in respiratory responses to internal physiological changes or external environmental challenges across the lifespan. Yet, despite considerable research defining the cellular and molecular mechanisms of respiratory neuroplasticity over the past three decades, we still know very little about sex differences or the specific role of sex hormones in the development of respiratory neuroplasticity. To address this gap in basic biological knowledge and support on-going translational studies devising novel ways to manipulate mechanisms of neuroplasticity for therapeutic benefit, our project investigates the mechanisms by which sex hormones, and specifically 17β-estradiol (the most abundant and neuroactive sex hormone in females), enable the development of respiratory motor plasticity in both females and males.

PI_NAMEs: DOUGHERTY, BRENDAN J (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Address;Androgens;Anti-Inflammatory Agents;Area;Biological;Biological Availability;Breathing;Cervical spinal cord structure;Characteristics;CSF1R gene;Data;Development;ESR1 gene;Estradiol;Estrogen Receptor 2;Estrogen Receptors;Estrogens;Excision;Female;flexibility;Flow Cytometry;genetic manipulation;Gonadal Hormones;Gonadal Steroid Hormones;Gonadal structure;GPER gene;hormonal signals;inhibitor;innovation;knock-down;Knowledge;life span;male;Mass Spectrum Analysis;Measures;Microglia;Molecular;Motor;Motor Neurons;Neurobiology;Neuronal Plasticity;neurophysiology;Neurophysiology - biologic function;neuroregulation;novel;Ovariectomy;pharmacologic;Pharmacology;Physiological;Population;Progestins;Protein Biochemistry;Protein Isoforms;Rattus;Receptor Signaling;Recovery;Regulation;Reporting;Research;Research Infrastructure;Research Personnel;Respiration;respiratory;response;Role;sex;Sex Differences;sexual dimorphism;Signal Transduction;siRNA delivery;Small Interfering RNA;Spinal;Spinal Cord;Supplementation;System;targeted delivery;Testing;Testosterone;Therapeutic;translational study;virtual;Work

PROJECT_TITLE: Estrogen Receptor Signaling in the Expression of Respiratory Motor Plasticity

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cannabidiol Research;Cannabinoid Research;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Natural Products;Opioid Misuse and Addiction;Opioids;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE The opioid epidemic continues despite the availability of medications that substitute for (methadone and buprenorphine) or block (naltrexone) most of the abuse-related effects of opioids, underscoring the need for new and better treatments. We hypothesize that the nonpsychoactive cannabinoid, cannabidiol (CBD) will be effective in treating various dimensions of opioid use disorder, including drug taking, relapse, and emergence of withdrawal. These studies in nonhuman primates complement and expand significantly recent promising results with CBD in humans.

PI_NAMEs: FRANCE, CHARLES P (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: abuse liability;Address;Adverse effects;Agonist;American;analog;antinociception;Attenuated;attenuation;behavior observation;Behavioral;Buprenorphine;Cannabidiol;cannabinoid receptor;Cannabinoids;Cannabis;Cessation of life;Clinical Trials;Cocaine;Cognitive;Complement;Data;Dependence;Dimensions;Dose;drug discrimination;Drug Kinetics;drug repurposing;Epidiolex;experimental study;FDA approved;Fentanyl;fentanyl self-administration;Food;Grant;Human;Impaired cognition;Individual;Infusion procedures;Laboratories;Legal;manufacture;marijuana use;Marinol;Medical;medication for opioid use disorder;Methadone;Monkeys;Morphine;Naltrexone;non-opioid analgesic;nonhuman primate;Opioid;opioid abuse;Opioid agonist;opioid epidemic;opioid overdose;opioid use disorder;opioid withdrawal;Patients;Pattern;Pharmaceutical Preparations;Physiological;Physiology;Pilot Projects;pre-clinical;prevent;Procedures;Public Health;Publishing;Recreation;Relapse;Request for Applications;Research;Self Administration;Sleep;Stimulus;Sucrose;Testing;Tetrahydrocannabinol;Therapeutic;Therapeutic Effect;Toxic effect;translational research program;United States National Institutes of Health;Withdrawal

PROJECT_TITLE: Discriminative Stimulus Effects of Opioid Withdrawal

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: DALLAS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Cells store lipids in specialized compartments called lipid droplets (LDs), which have numerous roles including energy reservoirs and platforms for metabolic reactions. LDs are made at specific sub-regions within the endoplasmic reticulum (ER), the metabolic center of cells, but how LDs and the ER network organize themselves to achieve all of their diverse functions is mechanistically unclear. This work will dissect how LDs and the ER network spatially compartmentalize their metabolic reactions, and achieve the functional diversity necessary for cells to maintain homeostasis, which is defective in disease states such as heart disease and atherosclerosis.

PI_NAMEs: HENNE, MIKE  (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TITLE: Spatial determinants in lipid metabolic organization at the sub-organelle level

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Cardiovascular;Clinical Research;Heart Disease;Immunotherapy;Prevention

ORG_CITY: SAN FRANCISCO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative (Relevance) The development of an imaging method for early detection of cardiotoxicity associated with cancer therapy is crucial for prevention and better management of cardiac complications in cancer patients and survivors. This technique would allow optimization of cancer therapy, help prevent serious cardiovascular problems, and lead to improved quality of life. In addition, this method could lead to development of new treatments for heart disease and heart-safe cancer therapies.

PI_NAMEs: LEVI, JELENA ;SEO, YOUNGHO  (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Address;age related;Animal Model;Anthracycline;Biological Markers;Blood;Blood Glucose;Cancer Etiology;cancer imaging;Cancer Patient;Cancer Survivor;cancer therapy;cancer type;Cardiac;Cardiac Myocytes;Cardiotoxicity;cardiovascular risk factor;Cardiovascular system;checkpoint therapy;chemotherapy;clinic ready;Clinical;cohort;combinatorial;comparative;Detection;Development;Diagnostic;diagnostic strategy;Diet;Doxorubicin;Early Diagnosis;Early identification;Evaluation;fluorodeoxyglucose;Functional disorder;Gender;Goals;Heart;heart damage;Heart Diseases;Heart failure;heart function;heart imaging;Heart Injuries;human subject;Image;imaging approach;imaging biomarker;imaging modality;Imaging Techniques;immune cell infiltrate;Immune checkpoint inhibitor;immune function;Immunotherapy;Impairment;improved;Inflammatory;Intervention;kinase inhibitor;Left Ventricular Ejection Fraction;Measurement;Mechanics;Mediating;Methods;Mitochondria;Molecular;Monitor;Morbidity - disease rate;mortality;Muscle Cells;Myocardial;Myocardial dysfunction;Myocarditis;Non-Invasive Detection;Normal Range;Oncologist;Oncology;Pathogenesis;Patients;Phase;Physiological;Positron-Emission Tomography;prevent;Prevention;Process;Quality of life;Recommendation;Research;Signal Transduction;Specificity;T cell infiltration;T-Cell Activation;targeted agent;targeted treatment;Techniques;Therapeutic Intervention;Tissues;tool;Toxic effect;Troponin I;uptake;Visualization

PROJECT_TITLE: [18F]F-AraG as an imaging biomarker for early diagnosis and monitoring of cardiotoxicity related to doxorubicin and immune check point inhibitor therapy

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Human Genome;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE The estimated effectiveness of the influenza vaccine in the U.S. for the 2018-2019 influenza season in older adults (≥65 years) was only 12-13%, demonstrating an urgent need to develop new approaches to improve influenza vaccine responsiveness in this high-risk population who constitute 90% of the 36,000+ annual U.S. influenza deaths. In this project, we will recruit and longitudinally follow a cohort of 60 older adults, who will receive 3 different influenza vaccines over 3 subsequent influenza seasons, including the most commonly used vaccine Fluzone® High-Dose and the first FDA-approved adjuvanted influenza vaccine, FLUAD®. By performing comprehensive profiling of their blood antibodies and immune cells over time, we will be able to associate specific age-related immune alterations with vaccine responder or non-responder status, thus allowing us to pinpoint biological pathways that can be targeted to enhance vaccine efficacy and that can also help us to progress towards developing a universal influenza vaccine.

PI_NAMEs: GARCIA-SASTRE, ADOLFO ;KUCHEL, GEORGE A;UCAR, DUYGU  (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: adaptive immunity;Adjuvant;Adult;age effect;age related;Aging;Antibodies;Antibody titer measurement;Antigen-Presenting Cells;Archives;ATAC-seq;B-Lymphocytes;Biological;Biological Assay;Blood;CD4 Positive T Lymphocytes;Cell Nucleus;Cells;Cellular Immunology;Cessation of life;Clinical assessments;cohort;Collaborations;Collection;COVID-19 vaccine;cytokine;data integration;data resource;Dendritic Cells;design;Dose;Effectiveness;epigenome;epigenomics;Epitope Mapping;Failure;FDA approved;Feces;Fluzone;follow-up;Future;Genetic Variation;Genome;Genomics;Goals;Helper-Inducer T-Lymphocyte;Hemagglutination;high risk population;human old age (65+);Humoral Immunities;Immune;immune function;Immunization Programs;immunogenic;Immunologic Memory;immunological status;immunosenescence;improved;Individual;Inflammatory;Influenza;Influenza A Virus, H7N9 Subtype;influenza epidemic;Influenza Hemagglutinin;influenza virus strain;influenza virus vaccine;influenzavirus;Interferons;Leukocytes;Longevity;longitudinal analysis;Longitudinal cohort;Messenger RNA;MF59;microbiome;Molecular;multiple omics;nasal swab;next generation;novel strategies;older adult;Older Population;Outcome Measure;Participant;Pathway interactions;Pattern;Phenotype;Populations at Risk;predicting response;primary outcome;Production;programs;Quantitative Trait Loci;Recording of previous events;recruit;Resources;responders and non-responders;response;RNA vaccine;Role;sample collection;Sampling;seasonal influenza;single-cell RNA sequencing;Specificity;Structure;synergism;Systems Biology;T-Lymphocyte;Technology;Time;transcriptome;universal influenza vaccine;Vaccinated;Vaccination;vaccination strategy;vaccine effectiveness;vaccine efficacy;vaccine response;Vaccines;Virus Diseases;volunteer

PROJECT_TITLE: A deep longitudinal analysis of next generation influenza vaccines in older adults


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Diabetes;Eye Disease and Disorders of Vision;Neurosciences;Prevention

ORG_CITY: Los Angeles

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Narrative Diabetic retinopathy is a major and common cause of vision loss in working age adults. The potential for early diagnosis and better monitoring of treatment based on non-invasive assessment of oxygen-metabolic metrics could significantly impact diabetic health care by improving the quality of life and reducing the cost of health care.

PI_NAMEs: SHAHIDI, MAHNAZ  (contact)

PROJECT_TERMS: Adult;Aftercare;Age;Anatomy;biomarker identification;Blindness;Blood capillaries;Blood flow;Blood Vessels;Caliber;care costs;Caring;Cell Survival;Cells;Classification;Clinical;Clinical assessments;Complications of Diabetes Mellitus;Data;Defect;density;Developed Countries;diabetic;Diabetic Retinopathy;Diagnosis;Diagnostic;Early Diagnosis;Equilibrium;Evaluation;Functional disorder;glycemic control;Glycosylated Hemoglobin;Growth;Health Care Costs;Healthcare;Hemoglobin concentration result;Hypoxia;Image;imaging approach;Impairment;improved;indexing;Individual;innovation;Knowledge;Light;macular edema;Maintenance;Measurement;Measures;Metabolic;Metabolism;Methods;Monitor;Morphology;Multimodal Imaging;neovascularization;non-diabetic;Optical Coherence Tomography;Oxygen;Oxygen saturation measurement;Pathology;Persons;Physiological;Population;Prediction of Response to Therapy;Prevention;preventive intervention;Production;prognostic;prospective;Public Health;Quality of life;Research Project Grants;Research Proposals;research study;response;Retina;retinal imaging;Schedule;Staging;study population;Subgroup;Therapeutic Intervention;Thick;Tissues;Treatment Factor;Treatment outcome;Vascular Endothelial Growth Factors;Vision;vision development;Visit;Visual Acuity;Visual impairment;visual processing;Work

PROJECT_TITLE: Imaging of Retinal Oxygen Metabolism in Diabetic Retinopathy


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Cardiovascular;Contraception/Reproduction;Genetics;Heart Disease;Human Genome;Hypertension;Kidney Disease;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Narrative Through the proposed study we hope to identify epigenomic markers of a dangerous and relatively common pregnancy-related condition called preeclampsia. During a preeclampsia pregnancy, babies are at risk for preterm delivery and low birthweight while mothers can suffer cardiovascular problems and even death. Finding genomic markers could allow doctors to diagnose preeclampsia early in pregnancy so they can treat the symptoms of the condition before long-term adverse effects occur to the mother and/or baby.

PI_NAMEs: HIDALGO, BERTHA  (contact);TITA, ALAN THEVENET N.;TIWARI, HEMANT K.

PROGRAM_OFFICER_NAME: YAN, YE

PROJECT_TERMS: Abnormal placentation;Adverse effects;adverse maternal outcomes;adverse outcome;Affect;Age;Alabama;Ancillary Study;Anti-Hypertensive Agents;biobank;Biological Assay;Biological Markers;Blood;Blood Banks;Blood Cells;Blood Pressure;Blood specimen;Blood Volume;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder risk;Cardiovascular system;case control;Cell Adhesion;cell bank;Cessation of life;Chemicals;Chronic;Chronic Kidney Failure;Circulation;Clinical;clinical diagnostics;clinical research site;Clinical Trials;cohort;Complication;Cytosine;Dangerousness;Data;Databases;design;Detection;Diabetes Mellitus;Diagnosis;Dinucleoside Phosphates;Discipline of obstetrics;Disease;Disease Marker;Disease Outcome;DNA Methylation;DNA Modification Process;Early Diagnosis;Early identification;early screening;efficacy evaluation;End stage renal failure;endothelial dysfunction;epigenetic marker;Epigenetic Process;epigenetic regulation;epigenome;epigenomics;fetal;Fetal Growth;First Pregnancy Trimester;Future;Gene Expression;Gene Expression Regulation;Genes;genomic biomarker;Guanine;Heritability;Hypertension;hypertensive;improved;Infant;Inflammation;Inflammatory;inorganic phosphate;Labetalol;Life;Low Birth Weight Infant;Maternal Health;Maternal Mortality;maternal risk;Measurement;Methylation;methylation pattern;Modification;Molecular;Monitor;Morbidity - disease rate;mortality;Mothers;Myocardial Infarction;National Heart, Lung, and Blood Institute;novel;Organ;Outcome;Oxidative Stress;parous;Participant;Pathology;pathophysiology of preeclampsia;Pathway interactions;Placenta;Placentation;Pre-Eclampsia;precision medicine;Pregnancy;Pregnancy Complications;pregnancy hypertension;Premature Birth;prepregnancy;prevent;programs;Proteins;Proteinuria;pyrosequencing;Randomized;Recording of previous events;release factor;Renal function;Reporting;Research;Research Design;Resources;Risk;Risk Factors;Safety;Sampling;Second Pregnancy Trimester;Site;Specimen;Stroke;symptom treatment;Symptoms;Testing;Third Pregnancy Trimester;Tissues;Transcriptional Regulation;treatment and outcome;Universities;Urine;Uterus;Vascular Diseases;Whole Blood;Woman;Women's Health

PROJECT_TITLE: Epigenetic biomarkers of preeclampsia risk among mothers with chronic hypertension

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Primary Health Care

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Adherence to prescribed medication regimens is critical to optimize both cognitive and physical health among older adults with Alzheimer’s disease and related dementias (ADRD) and other comorbid conditions, but is especially difficult in the context of multidrug regimens. Little is known about how older adults with ADRD self- manage their medications, how these responsibilities transition to caregivers as the disease progresses, how capable caregivers are to fulfill these responsibilities, and how ambulatory care practices support patients and caregivers to ensure safe medication use and adherence. This study will examine medication self-management behaviors among older adults with ADRD and multiple chronic conditions and their caregivers to inform patient- centered interventions.

PI_NAMEs: O'CONOR, RACHEL  (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Adherence;Adult;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Ambulatory Care;Attention;Behavior;Behavior assessment;Caregivers;Caring;Chronic Disease;Clinic;Clinical Management;Cognitive;Cognitive aging;cognitive change;cognitive function;cognitive task;cognitive testing;cohort;Cohort Studies;comorbidity;Complex;complex chronic conditions;Data Analyses;Dementia;Development;Disease;dosage;Dose;Drug Prescriptions;Elderly;Elements;Ensure;Ethnic Origin;Evaluation;Exclusion;experience;Exposure to;Face;follow-up;Foundations;Functional disorder;Funding;Goals;Health;health assessment;Health behavior and outcomes;human old age (65+);Impaired cognition;Individual;Intervention;Interview;Investigation;Knowledge;Measures;medical specialties;medication compliance;Medication Management;member;Memory;Mentored Research Scientist Development Award;Methods;mild cognitive impairment;multiple chronic conditions;older adult;Outcome;patient oriented;Patients;Pharmaceutical Preparations;physical conditioning;Primary Care;primary care clinician;primary care practice;Progressive Disease;prospective;provider factors;psychosocial;Quality of life;Race;Regimen;Research;Research Methodology;Role;Sampling;Schedule;Self Management;Self Medication;Severities;Structure;Symptoms;Techniques;Time;Training;treatment planning;Work

PROJECT_TITLE: Management of Complex Medication Regimens among Older Adults with Alzheimer's Disease and Related Dementias and their Caregivers

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Genetics;Kidney Disease;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Urologic Diseases

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

PHR: PROJECT NARRATIVE Kidney birth defects, which account for 25% of all birth defects in humans, are the leading cause of chronic renal disease in children and young adults. In the absence of curative treatment, patients rely on dialysis and kidney transplantation and consequently have significant shorter lifespan. In this project, we will model kidney birth defects to study the mechanisms that cause abnormal differentiation of renal cells, with the intention that this knowledge will advance the application of therapeutic strategies that depends on stem cell regeneration.

PI_NAMEs: FINER, GAL  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Address;Anatomy;beta catenin;Bilateral;Bioinformatics;Biological;Birth;Breeding;Cardiovascular system;career;Caring;Cell Lineage;Cell Maintenance;Cells;Child;Childhood;Chronic Kidney Failure;clinical training;Computational Biology;Congenital Abnormality;congenital anomalies of the kidney;curative treatments;Data;Defect;Development;Developmental Biology;Dialysis procedure;Dissociation;Distal;Doctor of Philosophy;Down-Regulation;Dysplasia;early onset;Endowment;Ensure;Environment;Epithelium;Equilibrium;Exhibits;experience;Extramural Activities;Funding;gain of function;Gene Expression Profiling;Genes;Genetic;genetic analysis;Genomics;Goals;Head;Heterogeneity;Human;Hypertension;Immunology;in vivo;Individual;Intention;International;K-Series Research Career Programs;Kidney;kidney cell;Kidney Failure;Kidney Transplantation;Knowledge;Lead;Life;life span;loss of function;Maintenance;Mediating;medical schools;Mentors;Mesenchyme;Metanephric Diverticulum;Methods;Modeling;Molecular;Molecular Analysis;Molecular Biology;Morphology;mosaic pattern;mouse model;multidisciplinary;multipotent cell;Mus;Natural regeneration;nephrogenesis;Nephrology;nephron progenitor;Nephrons;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Organoids;Pathogenesis;Pathway interactions;Patients;Phenotype;podocyte;Positioning Attribute;Pregnancy;premature;Prevention;professor;progenitor;Prophylactic treatment;Regulation;renal agenesis;Research;Research Personnel;Research Training;Resolution;Rest;RNA analysis;Role;Schools;self-renewal;Series;Severities;Signal Transduction;single-cell RNA sequencing;skills;stem cell differentiation;stem cell expansion;stem cell fate;stem cell self renewal;stem cells;stem-like cell;Stromal Cells;Survival Rate;symposium;Technology;Testing;Therapeutic;Time;transcription factor;Transplantation;Universities;Up-Regulation;Urinary tract;Vesico-Ureteral Reflux;WNT Signaling Pathway;Work;young adult

PROJECT_TITLE: Functional Analysis of the Role of Transcription Factor 21 (Tcf21) in Nephron Progenitor Cells in Congenital Anomalies of the Kidney and Urinary Tract

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE In this proposal, we will study how mechanical cardiac support influences myocardial tissue perfusion and coronary flow. We will use a catheter-based left ventricular assist device in large animal models of myocardial infarction to better understand the mechanism of infarct size reduction and how it can be improved further.

PI_NAMEs: ISHIKAWA, KIYOTAKE  (contact)

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: Acute;Acute myocardial infarction;Animal Experiments;Animal Model;Aortic Valve Insufficiency;Area;Biology;Blood;Blood flow;Blood Vessels;Cardiac;Catheters;cell type;Cells;Characteristics;Chronic;Clinical;Clinical Protocols;Consumption;Coronary;coronary artery occlusion;Coronary Occlusions;Coronary sinus structure;Coupled;Data;Development;Diastole;Diastolic blood pressure;Enrollment;exosome;Funding;Goals;Heart;Heart Atrium;improved;Individual;Infarction;inhibitor;Ischemia;Knowledge;Lasers;Left;left ventricular assist device;mechanical circulatory support;Mechanics;Mediating;Medicine;MicroRNAs;Microspheres;Molecular;Monitor;Muscle Cells;Myocardial;myocardial infarct sizing;Myocardial Infarction;Myocardial Ischemia;Myocardial perfusion;Myocardial Reperfusion;Myocardial tissue;novel;novel therapeutics;Output;Oxidases;Oxidative Stress;Oxygen;patient population;Patient Selection;Patients;Perfusion;pharmacologic;Phase;Phase II Clinical Trials;Physiologic intraventricular pressure;Physiological;Play;porcine model;pressure;Protein Isoforms;Regulation;Reperfusion Therapy;Role;safety and feasibility;Stress;stress reduction;Therapeutic Effect;Tissues;Ventricular;Work

PROJECT_TITLE: Increasing Ischemic Myocardial Tissue Perfusion by Mechanical LV Support

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Clinical Research;Genetics;Microbiome;Neurodegenerative;Neurosciences;Rare Diseases

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with no available cures. The intestine contains trillions of bacteria that influence many aspects of health and disease, and we have found that by affecting the bacteria in the gut in models of ALS, can alter disease progression. We will identify potential protective factors provided by the microbiota and investigate the immune mechanisms by which they act in hopes of identifying new therapeutic targets for treatment of ALS.

PI_NAMEs: WEINER, HOWARD L (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Address;Affect;ALS patients;Alzheimer's disease model;Amyotrophic Lateral Sclerosis;amyotrophic lateral sclerosis therapy;Animal Model;Antibiotic Therapy;Antibiotics;Bacteria;Brain;Butyrates;C9ORF72;Cd68;Clinical;cohort;Data;Disease;Disease Pathway;Disease Progression;Dose;Experimental Autoimmune Encephalomyelitis;Feces;Gene Expression Profile;Genes;Genetic Transcription;Goals;gut bacteria;gut microbiome;gut microbiota;Health;human microbiota;Immune;Immune system;Immunity;immunoregulation;Individual;Inflammatory;interest;Intestines;Investigation;Laboratories;Measures;Microbe;microbial;microbial products;microbiome;microbiome research;microbiota;Microglia;MicroRNAs;Modeling;monocyte;Motor;Motor Neurons;Mus;Nature;Nervous System Disorder;Neurodegenerative Disorders;neuropathology;neuroprotection;neurotoxicity;neurotransmission;new therapeutic target;Oral Administration;Paper;Pathogenesis;Pathway interactions;Patients;Peripheral;phase I trial;Phenotype;Play;Population;prevent;protective factors;protein degradation;protein TDP-43;Published Comment;Recovery;recruit;Reporting;RNA Processing;Role;Serum;Shapes;Signal Pathway;Sorting;Spinal Cord;superoxide dismutase 1;System;T-Lymphocyte;Testing;Therapeutic;Time;transcriptome sequencing;UBQLN1 gene

PROJECT_TITLE: Role of the Intestinal Microbiota in ALS

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: HOUSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Project Narrative During the development, mammalian cells undergo a series of cellular and molecular events that lead to the erasure and re-establishment of epigenetic programs. It is postulated that the active erasure and the re- establishment of DNA methylation marks during germ line differentiation, T-cell differentiation and brain development from fetus to young adult involve dynamic changes of methylated cytsoine into oxidative marks, and that these modified cytosine residues in DNA are recognized by specific transcription factors with distinct roles in the maintenance of epigenetic memory. A detailed biochemical and structural analyses of generation, recognition, alteration and erasure of these marks should shed light on this issue.

PI_NAMEs: CHENG, XIAODONG  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Biochemical;Brain;Cell Differentiation process;Cytosine;demethylation;Development;Dioxygenases;DNA;DNA Methylation;DNA Methylation Regulation;DNA Modification Methylases;DNA Modification Process;Enzymes;epigenetic memory;Epigenetic Process;epigenetic regulation;Event;Fetus;Gene Expression;Generations;Genome;Genomics;Germ Lines;histone methylation;Maintenance;Mammalian Cell;Mammals;Methylation;Modification;Molecular;oxidation;Positioning Attribute;programs;Proteins;Reaction;Role;Series;Structure;T cell differentiation;transcription factor;young adult

PROJECT_TITLE: Epigenetic regulations of DNA and histone methylation and deMethylation: Structures and Mechanisms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-G(55)R]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Orphan Drug;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative Liver metastases are common in colorectal cancer and knowledge of number, location and size impacts precision of therapy, survival and overall costs. Magnetic Resonance Imaging (MRI) is commonly used for evaluating liver metastases but detection and diagnosis of small tumors remains challenging. Our proposal is based on a collaborative integrated team of university scientists, clinician-scientists and industry engineers to develop and clinically trial new MRI technology that overcomes limitations related to imaging small liver tumors in patients.

PI_NAMEs: ALTBACH, MARIA I. (contact);MARTIN, DIEGO R

PROGRAM_OFFICER_NAME: AVULA, LEELA RANI

PROJECT_TERMS: 3-Dimensional;Abdomen;Accounting;accurate diagnosis;Adopted;Affect;Algorithms;alternative treatment;Arizona;Benign;Breathing;cancer imaging;Cessation of life;Chelating Agents;Clinic;Clinical;clinical practice;clinical translation;Clinical Trials;colon cancer patients;Colorectal;Colorectal Cancer;contrast enhanced;contrast imaging;cost;Country;Data;data acquisition;deep neural network;design;Detection;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic value;Discrimination;Disease;Drops;Early Diagnosis;efficacy evaluation;Engineering;Excision;flexibility;Gadolinium;Goals;Image;Image Analysis;Image Enhancement;image processing;image reconstruction;imaging facilities;imaging modality;Imaging Techniques;improved;Incidence;Industry;industry partner;Knowledge;Lesion;Life;Liver;liver imaging;Liver neoplasms;Location;Magnetic Resonance Imaging;Malignant - descriptor;Malignant Neoplasms;Maps;Medical;Metastatic Neoplasm to the Liver;Methods;Motion;Neoplasm Metastasis;new technology;next generation;novel;Operative Surgical Procedures;Outcome;Patient Selection;Patients;personalized care;Phase;Physiological;Population;Precision therapeutics;Radial;reconstruction;Reproducibility;Research;research clinical testing;Resectable;Resolution;Scanning;Scheme;Scientist;Sensitivity and Specificity;soft tissue;spatiotemporal;Techniques;Technology;Test Result;Translations;Treatment outcome;tumor;tumor specificity;Universities;Unresectable;Variant;Work

PROJECT_TITLE: Advancing MRI technology for early diagnosis of liver metastases


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Chronic Pain;Hematology;Neurosciences;Pain Research;Rare Diseases;Sickle Cell Disease

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Pain and sickle cell disease are so intimately intertwined, that African tribal words for the disease, spoken centuries before Herrick described sickle cell disease (SCD) in the western literature, are onomatopoeic for pain. In spite of it being almost one hundred years since Herrick's seminal report, the neurobiology of chronic pain in SCD is poorly understood. This program will apply cutting edge molecular, epigenetics and therapeutic tools for the study of mechanism and pharmacological treatment in well-characterized transgenic mouse models of sickle cell disease. Our long-term goal is to advance knowledge of the neurobiological mechanisms of chronic sickle cell pain and develop an effective pharmacologic treatment.

PI_NAMEs: WANG, ZAIJIE JIM (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Acute Pain;African;American;Chronic;chronic pain;Companions;design;Development;Disease;disease phenotype;effective therapy;Emerging Technologies;Epigenetic Process;flexibility;Goals;Human;inhibitor;innovation;Investigational Therapies;Knowledge;Literature;Methodology;Molecular;Molecular and Cellular Biology;mortality;mouse model;neurobiological mechanism;Neurobiology;Pain;Paper;Patients;Persons;Pharmacological Treatment;Pharmacology;phase 1 study;Probability;programs;Refractory;Reporting;Research;research facility;Seminal;Sickle Cell;Sickle Cell Anemia;sickling;Study models;success;System;targeted delivery;Therapeutic;tool;Transgenic Mice;Transgenic Model;Tribes

PROJECT_TITLE: Molecular mechanism and targeting of chronic pain in sickle cell disease


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Diabetes;Dietary Supplements;Heart Disease;Heart Disease - Coronary Heart Disease;Microbiome;Nutrition;Prevention

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Recent human studies report an emerging, novel relationship between the gut microbiome and its metabolites with the development of heart attacks and strokes. This application will determine whether these favorable effects are seen in individuals with type 2 diabetes who have a significantly different gut microbiota and microbiota metabolism than those without type 2 diabetes. Additionally, this application will serve as an excellent platform for mentoring post-doctoral fellows and junior faculty to learn how to conduct impactful patient-oriented human clinical translation research related to vascular biology.

PI_NAMEs: WIDLANSKY, MICHAEL E (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: acute coronary syndrome;Adipose tissue;Affect;Amines;Arterial Fatty Streak;Arteries;Atherosclerosis;Biological Assay;Biology;Biopsy;Blood Vessels;brachial artery;cardiovascular risk factor;Cardiovascular system;career;Cells;Clinical;clinical translation;Clinical Trials;combat;Coronary Arteriosclerosis;Data;design;Development;Diabetes Mellitus;Double-Blind Method;Endothelial Cells;Endothelium;Event;Faculty;Genetic Transcription;glucose tolerance;glycemic control;Goals;gut microbiome;gut microbiota;Human;human microbiota;improved;Incidence;Individual;Inflammation;Inflammatory;inflammatory marker;Insulin Resistance;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;interest;Intervention;Intestinal permeability;Investigation;K-Series Research Career Programs;Kidney Diseases;Knowledge;Laboratories;Lactobacillus plantarum;Learning;Measurement;Measures;Medicine;member;men;Mentors;Mentorship;Metabolism;Methods;microbiota;microbiota composition;Microvascular Dysfunction;Modification;Mononuclear;Myocardial Infarction;Neuropathy;next generation;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Oxides;patient oriented;patient oriented research;Patients;Physicians;Physiology;Pilot Projects;Placebo Control;Placebos;Plasma;Postdoctoral Fellow;Prevalence;probiotic supplementation;Probiotics;Production;programs;Publishing;Randomized;Reporting;Research;Research Personnel;Resistance;Retinal Diseases;Risk;Risk Factors;Scientist;Signal Transduction;Stroke;Structure;Study Subject;success;Supplementation;systemic inflammatory response;Techniques;Testing;Time;transcriptome;transcriptome sequencing;Translational Research;ultrasound;Vascular Diseases;vascular endothelial dysfunction;Vascular Endothelium;vascular inflammation;Vasodilation;Video Microscopy;Volatile Fatty Acids;Woman;Work

PROJECT_TITLE: Impact of L. plantarum 299v supplementation on endothelial function and inflammation in humans with type 2 diabetes

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


NIH_SPENDING_CATS: Cardiovascular;Pediatric;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The University of California, Los Angeles and Charles R. Drew University of Medicine and Science propose the Cultivating Interest in Research Careers (CIRC) Program, which will provide community college students from communities underrepresented in medicine and science (UIMS) with a summer research experience and a year-long advising program. The overarching goal of the CIRC Program is to prepare participating UIMS students for research careers in the biomedical and clinical health sciences.

PI_NAMEs: DURU, OBIDIUGWU KENRIK (contact);KERMAH, DULCIE

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Academic skills;Affect;African American;Area;Bachelor's Degree;Basic Science;Behavioral Research;Benchmarking;Biomedical Research;California;Cardiovascular Diseases;career;Career Choice;Career Mobility;Cause of Death;Cessation of life;Clinical;Clinical Research;Collaborations;college;Communication;Communities;community college;Community Participation;Coronary heart disease;Country;Data;disabled;disadvantaged student;Early Intervention;Education;Educational workshop;effectiveness evaluation;Enrollment;Ethnic Origin;experience;Exposure to;Faculty;follow-up;fundamental research;Funding;Future;Gender;Goals;hands on research;Health;Health Sciences;Heart Diseases;higher education;Individual;interest;K-Series Research Career Programs;Latinx;Los Angeles;Low income;Manuscripts;Mathematics;Measures;Medicine;Mentors;Mission;National Heart, Lung, and Blood Institute;National origin;Native Americans;Pacific Islander;Pathway interactions;peer;Prevention;Productivity;programs;Race;Research;Research Activity;Research Personnel;Research Training;school district;Science;science education;skills;social capital;socioeconomic disadvantage;socioeconomics;student participation;Student recruitment;student retention;Students;success;summer research;Supervision;System;timeline;Training;Translational Research;undergraduate education;undergraduate research experience;undergraduate student;Underrepresented Students;United States National Institutes of Health;Universities;university student;Work


NIH_SPENDING_CATS: Lung;Neurosciences;Orphan Drug;Rare Diseases;Sleep Research

ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Proposal Narrative Sighs are long, deep breaths essential for life by preventing lung collapse, and are regulated by hypoxia and sleep-wake states. The proposed studies will reveal the neural mechanisms of sighing in response to physiological conditions, and how these inputs are integrated. This work will provide novel insights on the neural basis of breathing pattern generation, and pave the way for developing targeted pharmacological treatments for breathing abnormalities.

PI_NAMEs: LI, PENG  (contact)

PROJECT_TERMS: Ablation;Affect;Alveolar;American;Apnea;Arousal;Atelectasis;Biological Assay;Brain;Brain Stem;Breathing;Calcium;Carbon Dioxide;Cause of Death;Clinical;Dedications;Diagnosis;Disease;experimental study;Failure;Foundations;Frequencies;Functional disorder;Functional Imaging;Gases;Gastrin releasing peptide;Generations;Genetic;Goals;Homeostasis;hypocretin;Hypothalamic structure;Hypoxia;imaging modality;improved;in vivo;in vivo imaging;insight;Knowledge;Laboratories;Leigh Disease;Life;Lung;Modality;Monitor;mouse genetics;Mus;neural;neural circuit;Neurologic;neuromechanism;neuromedin B;Neurons;Neuropeptides;neuroregulation;novel;novel therapeutic intervention;opioid mortality;optogenetics;Outcome;Oxygen;Pathologic;Pathway interactions;Patients;Pattern;Persons;pharmacologic;Pharmacologic Substance;Pharmacological Treatment;Pharmacology;Physiological;prevent;Process;pulmonary function;receptor;Respiration Disorders;respiratory;Respiratory distress;response;Rett Syndrome;Role;Sleep;Sleep Apnea Syndromes;Stimulus;Sudden infant death syndrome;Testing;transmission process;Work

PROJECT_TITLE: Neural circuit control of sighing


ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative FGF23 is a protein made by bones that causes the kidneys to get rid of phosphate. FGF23 levels are increased in acute kidney injury and may raise the risk of death. We will test whether a molecule called LPA causes FGF23 to increase in acute kidney injury, with the goal to make new drugs to treat this condition.

PI_NAMEs: SIMIC, PETRA  (contact)

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;Adult;Advisory Committees;Affect;Aging;alpha-glycerophosphoric acid;Applications Grants;Area;Attenuated;Bioinformatics;Biology;Blood;bone;C-terminal;Calcium;Calvaria;career;career development;Chemicals;Childhood;Chronic Kidney Failure;Circulation;Cisplatin;CRISPR/Cas technology;Data;Dedications;Development Plans;dihydroxy-vitamin D3;Dose;drug development;Endocrine;Excretory function;experimental study;Fellowship;fibroblast growth factor 23;Fibroblast Growth Factor Receptor 1;Future;G-Protein-Coupled Receptors;Gene Expression;Goals;Grant;Histology;Homeostasis;Hormones;Immunohistochemistry;Inflammation;inhibitor;Injections;Injury to Kidney;inorganic phosphate;insight;Investigation;Iron;Kidney;Kidney Diseases;kidney metabolism;Knockout Mice;Laboratories;liquid chromatography mass spectrometry;lysophosphatidic acid;Lysophosphatidic Acid Receptors;Manuscripts;Measures;Mediating;Mediator;medical schools;meetings;Mentors;Mentorship;Metabolism;metabolomics;Minerals;Modeling;Morbidity - disease rate;mortality;mortality risk;multidisciplinary;Mus;Names;Nephrology;new therapeutic target;novel;novel therapeutics;Osteoblasts;Osteocytes;Outcome;Outcome Measure;Pathway interactions;Physicians;Plasma;Probability;Production;Prognosis;Proteins;Proteomics;Public Speaking;Publishing;receptor;Renal function;renal ischemia;Reperfusion Injury;Research;Research Personnel;Research Training;Resources;response;responsible research conduct;rho;Risk Factors;Role;Science;Scientist;Serum;Signal Pathway;Signal Transduction;skill acquisition;Specificity;success;Testing;therapeutic target;Time;Tissues;Training;training opportunity;transcriptome sequencing;Translating;urinary;Urine;Work;Writing

PROJECT_TITLE: Lysophosphatidic acid (LPA) is a novel FGF23 regulator in acute kidney injury.


NIH_SPENDING_CATS: Clinical Research;Hematology;Microbiome;Pediatric;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Allogeneic stem cell transplant (SCT) is a life-saving treatment for children with leukemia, immunodeficiencies, and other disorders of the hematopoietic system, yet its success is limited by aberrant or delayed development of the new immune system. The gastrointestinal tract microbiota, and microbiome disruption that occurs over the course of SCT, may predict or even contribute to the pathogenesis of these immune-related outcomes, including graft-versus-host disease and time to immune cell recovery. This study will further define the relationship between microbiome disruption and immunologic outcomes of SCT, laying the foundation to develop new biomarkers and therapeutic approaches to improve the success of this treatment.

PI_NAMEs: ELGARTEN, CAITLIN WALFOORT (contact)

PROGRAM_OFFICER_NAME: FRANK, DANIEL J

PROJECT_TERMS: Acute Graft Versus Host Disease;Address;adverse outcome;Advisory Committees;Allogenic;Anti-Infective Agents;Antibiotics;Behavior;behavioral study;Bioinformatics;Biological Markers;Biology;bone marrow failure syndrome;Carbapenems;career;Cell Physiology;Cells;Child;Childhood;Childhood Leukemia;Clinical;Clinical Research;clinically relevant;clinically significant;cohort;Complex;Concentration measurement;Data;deep sequencing;Development;Disease;Drug Kinetics;Drug Targeting;Engraftment;Ensure;Environment;Epidemiologist;Epidemiology;Event;experience;Exposure to;Foundations;Future;Gastrointestinal tract structure;Goals;graft vs host disease;Healthcare;Hematological Disease;Hematopoietic System;Hemoglobinopathies;High-dimensional Modeling;host microbiome;Human;Immune;immune reconstitution;Immune system;Immune System Diseases;Immunity;immunodeficiency;Immunologics;improved;Individual;Infection;infection risk;interpatient variability;Intervention;Intervention Studies;Investigation;kinetic model;Kinetics;Knowledge;leukemia;Leukocytes;Life;Link;longitudinal analysis;Longitudinal cohort;Longitudinal Studies;Lymphopenia;Measurement;Measures;Mediating;Mentored Patient-Oriented Research Career Development Award;Mentorship;Metagenomics;Methods;microbiome;microbiome analysis;microbiome research;microbiome sequencing;microbiota;Modeling;Nature;Neutropenia;neutrophil;novel marker;Outcome;Pathogenesis;patient oriented research;patient variability;Patient-Focused Outcomes;Patients;Pediatric cohort;Pediatric Hospitals;Pediatric Oncologist;Pediatric Oncology Group;Pennsylvania;Peripheral;Pharmaceutical Preparations;pharmacodynamic model;Pharmacoepidemiology;pharmacologic;Philadelphia;Physicians;Physiological;Population;prevent;Prospective cohort;Quality of life;rational design;Recovery;Research;Research Personnel;Research Project Grants;Residual state;Resources;response;Risk;Sampling;Scientist;Signal Transduction;skills;Statistical Methods;Stem cell transplant;stem cells;success;Supportive care;System;Systems Development;Therapeutic;therapy design;Time;Training;Transplant Recipients;Transplantation and Immune System;Universities;Validation;Work

PROJECT_TITLE: Understanding longitudinal microbiome change in relation to immunologic outcomes in pediatric SCT recipients.


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Anxiety disorders and ADHD are two of the most common forms of childhood mental illness, can be highly impairing, and both include disruptions in attention. The goal of this study is to provide an in-depth characterization of how attention-related brain networks operate differently in children with anxiety disorders, ADHD, and both anxiety and ADHD compared to children with neither of these disorders. The results of this study are likely to assist in developing new treatments for pediatric anxiety and ADHD based on targeting these network-level disruptions.

PI_NAMEs: GILBERT, KIRSTEN ;SYLVESTER, CHAD MICHAEL (contact)

PROGRAM_OFFICER_NAME: PACHECO, JENNIFER LYNN

PROJECT_TERMS: Affect;Age;Anxiety;Anxiety Disorders;Area;Attention;Attention deficit hyperactivity disorder;Brain;brain circuitry;Child;Child Support;Childhood;childhood anxiety;comorbidity;computer game;Data;design;Development;Disease;effective therapy;Electroencephalography;EP300 gene;Event;Event-Related Potentials;Executive Dysfunction;executive function;experience;Feedback;Fright;Functional Magnetic Resonance Imaging;Goals;High Prevalence;Impairment;Light;Link;Location;Loudness;Measures;Mental disorders;Meta-Analysis;Morbidity - disease rate;Names;Nature;neural circuit;Neurosciences;Noise;novel;peer;personalized intervention;Play;Public Health;Reporting;Research;Research Personnel;research study;response;Signal Transduction;sound;Specificity;Stimulus;stressor;support network;System;Techniques;temporal measurement;Testing;therapy design;tool;treatment of anxiety disorders;Work;Youth

PROJECT_TITLE: Attention-Related Neural Circuitry in Pediatric Anxiety and ADHD


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Breast Cancer;Cancer;Childhood Leukemia;Hematology;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Cancer metastases to the leptomeninges (LM) are difficult to treat, create significant morbidity, and portend extremely poor survival. Our proposed work will define how malignant cells hijack developmental neuronal pathfinding mechanisms to enter the central nervous system. Our studies will provide new mechanistic insight into a poorly understood biologic phenomenon and a therapeutic approach to an area of high unmet clinical need.

PI_NAMEs: SIPKINS, DOROTHY A (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: acute lymphoblastic leukemia cell;Acute Lymphocytic Leukemia;Antibodies;Area;Automobile Driving;Basement membrane;Binding;Biological Phenomena;Biology;Blood - brain barrier anatomy;Blood Vessels;bone;Bone Marrow;Bone Surface;Brain;Breast Cancer Cell;Breast Cancer cell line;Bypass;Calvaria;cancer cell;cancer subtypes;Cell Line;cell motility;Cell surface;Cells;Central Nervous System;Central Nervous System Diseases;Circulation;Clinical;Clinical Data;Complex;Complication;Data;design;Development;Diagnosis;diagnostic tool;Disease;Disseminated Malignant Neoplasm;efficacy testing;Estrogen receptor positive;Event;Extracellular Matrix;FDA approved;Frequencies;genetically modified cells;Hematologic Neoplasms;high risk;Human;In Vitro;in vivo;Incidence;Individual;inhibitor;insight;Integrin alpha6;Integrins;Intervention;Intrathecal Chemotherapy;Invaded;Laboratories;Laminin;Laminin Receptor;Leptomeningeal Neoplasms;Leptomeninges;leukemia;Leukemic Cell;Malignant Breast Neoplasm;Malignant neoplasm of lung;Meningeal;Metastatic malignant neoplasm to brain;Metastatic Neoplasm to the Central Nervous System;Metastatic Neoplasm to the Leptomeninges;migration;Molecular;Molecular Target;molecular targeted therapies;Morbidity - disease rate;mouse model;Mus;Neoplasm Metastasis;nerve stem cell;neural;Neurons;novel;novel therapeutics;Pathway interactions;patient derived xenograft model;Patients;Peripheral;PIK3CG gene;Pre-Clinical Model;preclinical study;prevent;Prognostic Marker;prophylactic;Prophylactic treatment;receptor;Recurrent disease;Relapse;Reporting;Role;Sampling;Signal Transduction;Solid Neoplasm;Specimen;spine bone structure;stem;stem cells;Subarachnoid Space;Surface;Therapeutic;translational study;triple-negative invasive breast carcinoma;tumor;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Defining and targeting a novel pathway for central nervous system leptomeningeal metastasis

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Digestive Diseases;Infectious Diseases

ORG_CITY: COLLEGE PARK

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: Project Narrative  Identification of bacteria from intra-abdominal infections is needed to enable selection of an appropriate antibiotic, ideally within the first hour following diagnosis, but current methods impose long diagnostic delays that prevent effective drug selection. We propose a simple, inexpensive, and automated microwell array technology that will identify and quantify bacteria directly from intra- abdominal fluids within 10 min, meeting a critical unmet need for improving patient outcomes and reducing the spread of antibiotic-resistant bacteria.

PI_NAMEs: DEVOE, DON L (contact);WHITE, IAN M

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TITLE: A rapid, automated system for bacteria profiling of intra-abdominal infections

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Nutrition;Osteoporosis;Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: ROCHESTER

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE Use of androgen deprivation therapy (ADT), which causes near-total loss of testosterone, has increased dramatically in elderly prostate cancer patients over the last decade. ADT is associated with a 2% to 5% loss of bone mineral density, which is accompanied by significant increases in falls, fractures, and sarcopenia with significant decreases in balance and muscle strength compared to prostate cancer patients not on ADT and age- matched men without cancer. High-dose vitamin D is a promising intervention that may prevent these ADT- related consequences; if found to be efficacious, it would be a safe, low-cost, widely available, non- pharmacologic treatment that could drastically improve the prevention of ADT-induced bone loss and change clinical practice paradigms.

PI_NAMEs: PEPPONE, LUKE JOSEPH (contact)

PROGRAM_OFFICER_NAME: GOOD, MARGE

PROJECT_TERMS: Age;Agonist;Alcohols;American Society of Clinical Oncology;androgen deprivation therapy;antagonist;arm;Biological;Biological Markers;bisphosphonate;bone;bone cell;Bone Density;bone health;bone loss;Calcium;Cancer Center;Cancer Patient;Cancer Survivor;Cholecalciferol;Clinical;clinical practice;Clinical Practice Guideline;clinically relevant;Community Clinical Oncology Program;community setting;cost;Country;Data;design;Distal;Dose;Double-Blind Method;Dual-Energy X-Ray Absorptiometry;efficacy testing;Elderly;Ensure;Equilibrium;Exercise;falls;Femur;Fracture;fracture risk;GNRH1 gene;High Prevalence;high risk;high risk population;hip bone;Hip Fractures;Hip region structure;human old age (65+);Hypercalcemia;improved;Incidence;Intervention;Intervention Trial;Investigation;machine learning method;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;men;Metastatic Prostate Cancer;Morbidity - disease rate;mortality;Muscle;muscle form;muscle strength;Muscular Atrophy;Neck;Nonmetastatic;Nonpharmacologic Therapy;novel;older patient;Oncologist;Osteoporosis;Outcome;Participant;Pathway interactions;Patients;Peptide Initiation Factors;pharmacologic;Phase;Pilot Projects;placebo group;Placebos;Population;Preparation;prevent;Prevention;Preventive treatment;primary outcome;programs;Prostate Cancer therapy;Publishing;Quality of life;Radial;Randomized;Randomized, Controlled Trials;Recommendation;Regimen;Research;response;Safety;sarcopenia;secondary outcome;Serum;side effect;Site;Skeletal Muscle;Smoking;Supplementation;Testosterone;Toxic effect;Universities;Vertebral column;Vitamin D;Vitamin D supplementation

PROJECT_TITLE: High-dose Vitamin D Supplementation for ADT-Induced Bone Loss in Older Prostate Cancer Patients

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: PEDIATRICS

PHR: Project Narrative Consumption of sweetened beverages, media-viewing, and physical activity patterns are often established during early childhood, and family-based obesity interventions show effectiveness in shaping healthy behaviors and weight outcomes for young children, including Latino children. Missing from these interventions, however, are methods to increase accessibility and dissemination to multiple family caregivers. The proposed work will use a randomized study design to evaluate the impact a family-based early childhood obesity intervention for Latino families that incorporates evidence-based strategies of in-person childhood obesity interventions, mobile phones, and leverages important determinants of Latino health (e.g. familism, language) in order to decrease ethnic disparities in childhood obesity and cardiovascular risk.

PI_NAMEs: GUERRERO, ALMA D (contact)

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: 5 year old;Academy;Address;Adolescent;Adult;Age;Agreement;American;arm;Attenuated;Behavior;Behavioral;Body mass index;Body Weight Changes;cardiovascular risk factor;Cardiovascular system;Caregivers;Cellular Phone;Child;Child Care;Child Development;Child Health;Child Rearing;Clinical Trials;Collaborations;community intervention;community setting;Consumption;Control Groups;County;cultural values;Data;design;dietary;Dietary Practices;early childhood;Educational Curriculum;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;ethnic disparity;evidence base;excessive weight gain;experience;Family;Family Caregiver;Family member;Fathers;feasibility testing;feeding;Foundations;grandchild;grandparent;group intervention;Guidelines;Health;Health Benefit;health communication;Home;Household;Hybrids;improved;Infant;Infant Care;Intake;Intervention;intervention effect;K-Series Research Career Programs;Language;Latino;Latino Population;Length;Life Cycle Stages;Life Style;Los Angeles;Low income;Mediating;Mediator;Methods;mhealth interventions;Mothers;Nutritional;Obesity;obesity in children;obesity risk;obesity treatment;obesogenic;Outcome;overweight adults;overweight child;Parents;Pattern;Pediatrics;Persons;Physical activity;Play;post intervention;Preparation;Prevalence;prevent;primary outcome;prospective;Protocols documentation;Public Health;racial disparity;Randomized;recruit;Research Design;Resources;Risk;Role;role model;scale up;Schools;secondary outcome;Shapes;skills;social influence;Socialization;Surveys;sweetened beverage;Systems Theory;Television;theories;Time;Travel;treatment as usual;treatment site;United States National Institutes of Health;Weight;Weight Gain;Woman;Work;Youth

PROJECT_TITLE: A Hybrid Mobile Phone Family Intervention to Prevent Childhood Obesity

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: Aurora

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Metallosis is a condition where the tissue around implanted metal orthopedic devices is stained black by the metal released from the implants due to corrosion and can cause severe pain, tumor growth, and even heart issues. We will see if bacteria that live in the tissues cause this corrosion. The impact of this will be to give insight to how corrosion occurs in patients, thus leading to possible changes in clinical treatments, the necessity of new or modified materials, or changes to surgical procedures to reduce the risk of metallosis.

PI_NAMEs: AYERS, REED A (contact)

PROGRAM_OFFICER_NAME: WANG, XIBIN

PROJECT_TERMS: 3-Dimensional;Affect;Alloys;Area;Bacteria;Bacterial Infections;Biological;bone;Cardiotoxicity;Chemicals;Citrobacter;Clinical;clinical diagnosis;Clinical Treatment;Control Groups;Corrosion;Corrosives;Data;Devices;Diagnosis;Environment;Exposure to;Failure;Foot Process;Health;Heart;Implant;In Situ;In Vitro;in vivo;Indolent;Infection;infection rate;infection risk;insight;instrumentation;Ions;Joints;Klebsiella;Knowledge;Location;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Measures;Mechanics;Metal exposure;Metals;Methods;Microbe;microbial;Microbial Biofilms;microbiome;Microscopy;Modification;Muscle;neurotoxicity;Operative Surgical Procedures;Optics;Orthopedics;Pain;particle;patient safety;Patient-Focused Outcomes;Patients;polymicrobial biofilm;Property;response;Risk Reduction;Rod;Roentgen Rays;Scanning;Serum;Skin;Spectrum Analysis;Spinal;Stains;Surface;Surgeon;Testing;time use;Tissue Stains;Tissues;Titanium;tumor growth;two-dimensional;Vertebral column;Work

PROJECT_TITLE: In-vivo polymicrobial biofilms resulting in implant corrosion and metallosis

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homelessness;Mental Health;Pediatric;Prevention;Social Determinants of Health;Violence Research;Youth Violence

ORG_CITY: CHESTNUT HILL

ORG_NAME: BOSTON COLLEGE

PHR: PROJECT NARRATIVE  The proposed research is the first known effort in Sub-Saharan Africa to examine modifiable risk and protective biobehavioral mechanisms driving the intergenerational effects of war on the mental health of offspring aged 7–24. This intergenerational research of child and youth mental health will have both domestic and global public health significance given current estimates of approximately 79.5 million forcibly displaced people including refugees, internally displaced persons, and asylum seekers worldwide; an estimated 30–34 million (38–43%) are children under age 18. Many populations remain in proximity (within 31 miles) to war with approximately 368 million children and 265 million women living in areas affected by armed conflict. Potential findings may be valuable to United States Government efforts to improve security, human rights, and economic development in regions affected by armed conflict; and have implications for U.S. military personnel and their families as well as migrants and refugees from a variety of backgrounds.

PI_NAMEs: BETANCOURT, THERESA STICHICK (contact)

PROGRAM_OFFICER_NAME: CUBILLOS, LEONARDO

PROJECT_TERMS: Address;Adult;Affect;Africa South of the Sahara;Age;aged;Anxiety;Area;Articulation;Automobile Driving;Autonomic nervous system;Behavior assessment;Behavioral;biobehavior;Biological;biological adaptation to stress;Biological Markers;Biophysics;Child;Child Development;Child Mental Health;Child Rearing;Childhood;Clinical assessments;Cognition;cognitive function;cohort;Collaborations;Collection;Communication;Communities;community advisory board;Conflict (Psychology);coping;Data;Data Collection;Development;displaced person;Early-life trauma;Ecology;Economic Development;Economics;Education;emotion regulation;Emotional;emotional functioning;Emotions;Ensure;Equation;Ethics;Exposure to;Family;Family Violence;Female;Funding;Generations;Government;Growth;Health;Heritability;Hospitals;Human Resources;Human Rights;improved;Individual;Inflammation;Informal Social Control;innovation;intergenerational;Intervention;Investigation;Knowledge;Length;Life;Link;Longitudinal Studies;low and middle-income countries;male;Measures;Mental Depression;mental development;Mental disorders;Mental Health;Migrant;Military Personnel;Modeling;modifiable risk;National Institute of Child Health and Human Development;next generation;offspring;Outcome;Parent-Child Relations;Parents;participant retention;Pathway interactions;Pattern;physical conditioning;Physiological;Population;Population Heterogeneity;post-traumatic stress;Prevention;preventive intervention;Process;prospective;protective factors;Psyche structure;Public Health;Recording of previous events;Refugees;Research;Research Domain Criteria;Research Personnel;Risk;Risk Factors;Sampling;Screening procedure;Security;Sierra Leone;Skin;social;Social Functioning;social stigma;Social support;Social Work;Soldier;State Government;Stress;stress reactivity;stressor;substance use;support tools;Techniques;telomere;Time;trait;transmission process;Trauma;trauma exposure;United States;Universities;Violence;War;Woman;young adult;Youth

PROJECT_TITLE: Social and Biological Mechanisms Driving the Intergenerational Impact of War on Child Mental Health: Implications for Developing Family-Based Interventions


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Complementary and Integrative Health;Machine Learning and Artificial Intelligence;Neurosciences;Pain Research;Rehabilitation

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Intrathecal oxytocin is in clinical trials as an opioid alternative for chronic pain treatment. Our work in mice suggests that coupling intrathecal oxytocin with manual therapies (i.e. massage) optimizes the analgesic properties of oxytocin. This project provides the framework to support this combination therapy by concentrating on the spinal cord circuit mechanisms by which oxytocin alleviates pain.

PI_NAMEs: ABRAIRA, VICTORIA EUGENIA GUADALUPE (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Absence of pain sensation;Affective;Analgesics;Animals;Anterolateral;autistic children;Behavior;Behavior Therapy;Behavioral;Behavioral Assay;behavioral study;Biological Assay;Brain;brain circuitry;Chronic;chronic pain management;Clinic;Clinical Trials;Combined Modality Therapy;Computer Vision Systems;Coupling;Data;differential expression;Dimensions;Dissection;dorsal horn;dosage;efficacy evaluation;Electrophysiology (science);emotional experience;experience;experimental study;Female;genetic approach;Histologic;Human;human tissue;Image;injured;innovation;Interneurons;Learning;Machine Learning;male;Manipulative Therapies;Maps;Massage;Mechanoreceptors;Mediating;Methods;Modeling;Molecular;Morphology;Motivation;Mus;Negative Valence;Nervous System;Neuromodulator;Neurons;Neuropeptides;Nociception;Nociceptors;novel;novel therapeutics;Opioid;Output;Oxytocin;Oxytocin Receptor;Pain;Pain management;Pain Measurement;Peripheral;pharmacologic;Pharmacology Study;Physiology;Positive Valence;pre-clinical;Preparation;Property;Rattus;receptor;receptor expression;Reflex action;Reproducibility;Research;Resource Sharing;response;Rodent;Rodent Model;Sensory;sensory stimulus;Shapes;Signal Transduction;Skin;Social Behavior;Social Interaction;social learning;Spinal;Spinal Cord;Standardization;Stimulus;Synapses;System;Techniques;Testing;tool;Touch sensation;Translating;two-photon;Work

PROJECT_TITLE: Refining oxytocin therapy for pain: context is key

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Digestive Diseases;Genetics;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative  Combination MEK/autophagy inhibition has shown promise in some pancreatic ductal adenocarcinoma patients, but responses have been variable and of limited duration. Using single cell RNA sequencing and an advanced computational framework, we have identified three predominant cell types in pancreatic tumors that respond to MEK/autophagy inhibition. We propose to study the mechanisms of these responses and evaluate potential combination agents that will potentiate the anticancer effects of this regimen.

PI_NAMEs: MANJI, GULAM ABBAS;OLIVE, KENNETH P. (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Alleles;anti-cancer;Automobile Driving;Autophagocytosis;Behavioral;Biological Models;Biology;cancer cell;Cancer Etiology;Case Study;Cell Line;Cell Survival;cell type;Cells;Cessation of life;Chemoresistance;chemotherapy;Clinical;Clinical Research;Clinical Trials;Collaborations;combinatorial;Complement;Complex;computer framework;Cytotoxic Chemotherapy;Data;design;drug sensitivity;early phase clinical trial;Epigenetic Process;Epithelial Cells;Epithelium;Exhibits;Feedback;Fibroblasts;Genetic Engineering;Genetically Engineered Mouse;genotoxicity;Goals;Heterogeneity;holistic approach;Human;Human Cell Line;Immunosuppression;Immunotherapeutic agent;Immunotherapy;In Vitro;Individual;inhibition of autophagy;inhibitor;innovation;Investigation;KPC model;KRAS2 gene;KRASG12D;Learning;Letters;Macrophage;Malignant - descriptor;Malignant Epithelial Cell;Malignant neoplasm of pancreas;Malignant Neoplasms;malignant phenotype;Measures;MEK inhibition;MEKs;Modeling;Molecular;monocyte;mortality;mouse model;Mus;Mutagens;mutant;Mutate;Mutation;non-genetic;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Olives - dietary;Oncogenes;Oncogenic;Outcome;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic neoplasm;Pathway Analysis;Pathway interactions;patient derived xenograft model;patient subsets;Patients;Pharmaceutical Preparations;Phase Ib/II Clinical Trial;Phenotype;Population;pre-clinical;preclinical study;Printing;Property;Publishing;Recording of previous events;Regimen;Reporting;Residual state;Resistance;resistance mechanism;response;Role;Sampling;single-cell RNA sequencing;Slice;synergism;Systems Biology;targeted treatment;Testing;Tissues;TP53 gene;transcription factor;treatment effect;treatment response;tumor;tumor microenvironment;United States;Up-Regulation;Work;Xenograft Model

PROJECT_TITLE: Targeting cell regulatory states to complement MEK/autophagy inhibition in pancreatic cancer

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Arthritis;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

PHR: PROJECT NARRATIVE Arboviruses, including alphaviruses, are major public health concerns, and the capacity of an arbovirus to be transmitted in a human-mosquito-human transmission cycle has fueled outbreaks worldwide and is dependent on both the magnitude and duration of viremia. The host protein MARCO is a determinant of viremia by removing arthritogenic alphaviruses, for example chikungunya virus, from circulation. This project aims to determine molecular mechanisms of interaction between MARCO and arthritogenic alphaviruses, define viral features required for MARCO recognition, and elucidate the precise role of MARCO in alphaviral pathogenesis, ultimately expanding our knowledge about the innate immune system and building a foundation for potential therapies targeting alphaviral infections.

PI_NAMEs: LI, FRANCES SHIEH (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: acetyl-LDL;Affect;Alpha Virus;Amino Acids;Arboviruses;Arthritogenic;arthropod-borne;Binding;Binding Sites;Biochemical;Biological Assay;Blood;Cells;Charge;chikungunya infection;Chikungunya virus;Circulation;Clinical;Communicable Diseases;Culicidae;Disease Outbreaks;Evaluation;Excision;feeding;Foundations;Genetic Polymorphism;Geography;Glutamates;Glycoproteins;Human;In Vitro;in vivo;Individual;Infection;Innate Immune System;insight;Invertebrates;Kinetics;Knowledge;Kupffer Cells;Laboratories;Life Cycle Stages;Ligands;Low-Density Lipoproteins;Lysine;Mass Spectrum Analysis;Methylation;Modification;Molecular;Mus;Mutate;Mutation;nonhuman primate;O'nyong'nyong;Outcome;particle;pathogen;Pathogenesis;Pattern recognition receptor;Periodicals;Population;Positioning Attribute;Post-Translational Protein Processing;Predisposition;Proteins;Public Health;Publishing;Reader;Reporting;Role;RXR;scavenger receptor;Scavenger Receptor Cysteine-Rich Domain;Serum;Severity of illness;Site;SR-A proteins;SRCR proteins;Surface;Surface Plasmon Resonance;targeted treatment;transmission process;Tuberculosis;Variant;Vertebrates;Viral;Viremia;Virion;Virus;virus host interaction

PROJECT_TITLE: Defining viral-host interactions between arthritogenic alphaviruses and MARCO


NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Cannabinoid Research;Clinical Research;Complementary and Integrative Health;Electronic Nicotine Delivery Systems;Lung;Natural Products;Pediatric;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Over 10% of the U.S. population is using e-cigarettes and vaping devices, with upwards of 25% of middle- schoolers and 50% of high-schoolers vaping regularly. A new generation of patient oriented researchers are needed to define and treat the health problems that will occur due to the use of these drug delivery devices. As a successful mid-career clinician, researcher and dedicated mentor, I request K24 support to protect my time such that I may expand my patient oriented research, develop my research expertise in new ways and increase my mentorship of outstanding junior investigators.

PI_NAMEs: CROTTY ALEXANDER, LAURA ELISE (contact)

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: Acute;Adolescent and Young Adult;Adverse effects;Advertising;Aerosols;Affect;Age;age group;Age Years;airway inflammation;antimicrobial;Area;Asthma;asthmatic;Award;Back;Belief;Body System;Cannabinoids;career;CCL2 gene;Cell Physiology;Cells;Chemicals;Chronic;Chronic Disease;cigarette smoke;Clinical;Clinical Research;cohort;combustible cigarette;Compensation;Country;COVID-19;cytokine;Data;Dedications;design;Development;Devices;Disease;Drug Delivery Systems;Drug usage;e-cigarette aerosols;Electronic cigarette;electronic cigarette use;electronic cigarette user;Ensure;eosinophil;Eosinophilia;Eotaxin;Epidemic;epidemiologic data;Evolution;experience;Explosion;Extrinsic asthma;Faculty;Feeling;Fibrosis;Generations;Glycerol;Grant;Health;health assessment;Heart;high risk population;High School Student;Host Defense;Human;human subject;IL8 gene;Immune;Immunologics;immunoregulation;improved;Inflammatory;Inhalant dose form;Inhalation;Institutional Review Boards;Interleukin-4;Interleukin-5;Interleukin-6;Kidney;Learning;Life;Liver;Longitudinal Studies;Lung;lung injury;Marijuana Smoking;marijuana user;Medicine;Memory;Mentors;Mentorship;methacholine;microbiome;mid-career faculty;monocyte;Nasal Epithelium;National Heart, Lung, and Blood Institute;neutrophil;never smoker;Nicotine;non-smoking;novel;Paper;patient oriented;patient oriented research;Patients;periostin;Persons;Phenotype;Physiological;Plasma;Population;Positioning Attribute;Predisposition;Productivity;professor;Propylene Glycols;Protocols documentation;Publishing;Pulmonary Function Test/Forced Expiratory Volume 1;Pulmonary Inflammation;RANTES;Recontacts;recruit;Recruitment Activity;Research;Research Design;Research Personnel;Running;Safety;Saliva;sex;skills;Smoke;Spirometry;Sputum;success;systemic inflammatory response;Techniques;Tetrahydrocannabinol;Time;Tobacco;Tobacco Industry;Training Support;transcriptome sequencing;Translational Research;vaper;vaping;vaping THC;Visit;Vitamin E;Work;young adult

PROJECT_TITLE: Convergence of Vitamin E, THC, Nicotine, Propylene Glycol and Glycerin Effects on Lung Inflammation When Vaped