ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: This proposal is focused on structure-function analysis of the nuclear receptor retinoic acid receptor-related orphan receptor gamma or RORy, a transcription factor involved in regulation of glucose and lipid metabolism and immune functions. Given the importance of RORy as a therapeutic target, it is surprising that we have an incomplete understanding of how small molecules modulate its activity where the mechanism for "turning off" RORy activity appears straightforward, yet it is less clear how the receptor is "turned on." The studies proposed here will illuminate RORy activation mechanisms that will help develop better tools to study its pharmacology and can lead to new therapeutic strategies by designing functionally selective ligands.

PI_NAMEs: GRIFFIN, PATRICK ROBERT (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Affinity;Agonist;Allosteric Regulation;antagonist;Binding;Biological Assay;blood glucose regulation;Bone Growth;CD4 Positive T Lymphocytes;Cells;circadian pacemaker;Circadian Rhythms;Communication;Complex;crosslink;Crosslinker;Data;design;Development;DNA;DNA Sequence;Genes;genetic analysis;glucose metabolism;Hepatocyte;human disease;immune function;Immunity;Immunosuppression;insight;Length;Ligand Binding;Ligands;lipid metabolism;Liver;Modeling;monomer;mutant;Mutation;Mutation Analysis;N-terminal;Names;NCOA2 gene;NCOA3 gene;novel therapeutic intervention;NR1 gene;Nuclear Receptors;Oligonucleotides;Orphan;overexpression;Pathogenicity;Peptides;Pharmacology;Physiological;Physiology;Play;Process;programs;promoter;Protein Isoforms;protein purification;Proteins;Proteomics;receptor;Receptor Activation;recruit;Regulation;Reporter;Reporting;response;Response Elements;Retinoic Acid Receptor;Role;small molecule;Source;Steroid Receptors;Sterols;Structural Models;Structure;T-Lymphocyte;Testing;therapeutic development;therapeutic target;tool;Transactivation;Transcription Coactivator;transcription factor;transcriptome;tumor;Validation

PROJECT_TITLE: Quantifying and modeling ligand-dependent control of RORγ dynamics via structural proteomics

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: CHICAGO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Dysregulations or mutations found within epigenetic factors are shown to be the main drivers in many human diseases. In this study, we will investigate the function of a novel epigenetic axis comprised of BAP1/ASXL3/BRD4 by examining: 1) its mechanism involving modifications to gene expression based on chromatin signatures at active enhancer regions, 2) modulating the activity of this multi-protein complex by small- molecule inhibitors, and 3) further expanding and applying this study in the context of mouse embryonic stem cell differentiation. Ultimately, this study will help identify novel therapeutic targets to develop practical therapeutic approaches for diseases induced by epigenetic-related disorders.

PI_NAMEs: WANG, LU  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Attenuated;Biochemical;Biological Markers;Bromodomain;Cells;Chromatin;Chromatin Structure;Complex;Development;developmental disease;Developmental Process;Disease;driver mutation;Enhancers;Epigenetic Process;Equilibrium;Functional disorder;Gene Expression;gene repression;Genes;Genetic;Genetic Transcription;Goals;Histone H2A;histone modification;Histones;human disease;Lysine;Malignant Neoplasms;Mammalian Cell;Mammals;Mediating;Modification;Molecular;Mouse Embryonic Stem Cells;Multiprotein Complexes;Mutation;nerve stem cell;Neurons;new therapeutic target;novel;novel therapeutics;Patients;Play;Polycomb;PRC1 Protein;Prognostic Marker;Proteins;recruit;Role;Scaffolding Protein;screening;small molecule;small molecule inhibitor;stem cell differentiation;Therapeutic;Transcription Coactivator;Transcriptional Regulation;transcriptome;ubiquitin isopeptidase;Ubiquitination

PROJECT_TITLE: Role of BAP1/ASXL3 complex in transcriptional regulation and development

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: NARRATIVE RNA decay is critical for proper cellular functions and homeostasis. In this proposal, we exploit novel RNA sequencing methods to develop a mechanistic understanding of a conserved biological mechanism of co- translational mRNA decay known as “ribothrypsis”. Deciphering the biology of ribothrypsis will enhance our understanding of how gene dysregulation underlies human diseases, paving the way to the development of new RNA-based diagnostics.

PI_NAMEs: IBRAHIM, FADIA FAYEZ (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TITLE: Mechanism for post-transcriptional gene regulation by Ribothrypsis

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ORG_CITY: INDIANAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Narrative Sepsis-induced kidney injury is a major cause of mortality and morbidity in hospitalized patients. The kidney is a highly complex organ and propagation of septic injury involves intimate cross talk among various renal cell types. We examine the roles of renal purine homeostasis with the hope of developing targeted therapy for sepsis.

PI_NAMEs: DAGHER, PIERRE C (contact)

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Affect;Animals;arms race;bactericide;Biochemical;Bioenergetics;Biological Markers;Bone Marrow;Catalysis;Cell Communication;Cell Physiology;cell type;Cells;Clinical;Clinical Trials;Complex;Data;Degradation Pathway;Deuterium Oxide;Development;Disadvantaged;effective therapy;Endotoxins;Enzymes;Free Radicals;Functional disorder;Generations;Goals;Health;Homeostasis;Hospitalization;Injury;Injury to Kidney;Kidney;kidney cell;Knock-in Mouse;Label;Laboratories;Macrophage;Maintenance;Measures;Metabolic Pathway;metabolomics;Modeling;Modification;Molecular;Molecular Target;Morbidity - disease rate;mortality;Mouse Strains;Mus;Nucleic Acids;Organ;Oxidases;oxidation;oxidative damage;Oxidative Stress;Oxidoreductase;pathogen;Pathologic;Pathway interactions;Patients;pharmacologic;Precision therapeutics;preconditioning;Prevention;protective pathway;purine metabolism;Purines;Reaction;Reactive Oxygen Species;renal damage;Role;sensor;Sepsis;septic;Signal Transduction;System;targeted treatment;Techniques;Testing;Therapeutic;therapeutic target;Tissues;transcriptomics;Tubular formation;uptake;Uric Acid;urinary;Work;XDH gene

PROJECT_TITLE: Endotoxin preconditioning as a model to uncover protective pathways in sepsis-induced renal injury

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative  Hypoglycemia caused by insulin usage in diabetic patients is a serious health risk which can lead to cognitive impairment, brain damage, coma, and death. The proposed research will test the novel hypotheses that astrocytes contribute to hypoglycemia-induced cerebral blood flow (CBF) increases and that long-term diabetes leads to compromised CBF regulation. A fuller understanding of the cellular mechanisms responsible for the regulation of CBF may lead to therapies for reducing the harmful effects of diabetes and hypoglycemia on the brain.

PI_NAMEs: NEWMAN, ERIC A (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Acids;Adenosine;Animals;antagonist;arteriole;Astrocytes;awake;Blood capillaries;Blood Glucose;Blood Vessels;Brain;Brain Injuries;Calcium Signaling;Cells;Cerebrovascular Circulation;Cerebrum;Cessation of life;Chronic;Cognitive deficits;Coma;Complications of Diabetes Mellitus;Deoxyglucose;deprivation;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic patient;Diameter;euglycemia;experience;experimental study;Fluorescent Dyes;Glucose;Health;Human;Hyperemia;Hyperglycemia;Hypoglycemia;Impaired cognition;inhibitor;Injections;inorganic phosphate;Inositol;Insulin;Knockout Mice;Lead;Longitudinal Studies;Measures;Mediating;Mediator;Membrane;Modeling;Monitor;Mus;Neurons;neurovascular coupling;novel;Oxygen;Penetration;Process;Prostaglandins;Purinergic P1 Receptors;receptor;Regulation;Research;response;Risk;Signal Transduction;Somatosensory Cortex;Starvation;Testing;two photon microscopy;Unconscious State;Vasodilation;Vasodilator Agents;Vibrissae;Wild Type Mouse;Work

PROJECT_TITLE: Astrocyte regulation of cerebral blood flow during hypoglycemia


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Prevention

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Genetic differences in how people metabolize cholesterol contribute substantially to the risk of coronary artery disease, which is one of the most common causes of death and disability in the USA. Large population genetic studies have flagged regions of the genome where genetic differences influence cholesterol levels, but it is unknown how these genetic differences alter cholesterol levels. We will pinpoint mechanisms driving genetic differences in cholesterol levels using CRISPR gene editing, which may lead to new therapeutic interventions to reduce the risk of coronary artery disease.

PI_NAMEs: SHERWOOD, RICHARD I (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: Affect;Automobile Driving;base editing;Binding Sites;biobank;Biological;Biological Assay;Biological Models;Cause of Death;Cell model;Cells;Cholesterol;Cholesterol Homeostasis;Chromatin;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Code;cohort;Cohort Analysis;Complex;Complex Genetic Trait;computational suite;Computational Technique;Computer Analysis;Coronary Arteriosclerosis;CRISPR screen;CRISPR/Cas technology;Data;Defect;disability;Disease;disorder risk;Dissection;exome sequencing;experimental analysis;Foam Cells;follow-up;Gene Cluster;gene network;Genes;Genetic;Genetic Population Study;Genetic Screening;Genetic Transcription;genetic variant;Genetic Variation;Genome;genome wide association study;genome-wide analysis;genomic data;genomic locus;Genomic Segment;Heart Diseases;Hepatocyte;HepG2;High Density Lipoprotein Cholesterol;High Density Lipoproteins;Human;Human Genetics;in vitro Assay;in vivo Model;Individual;Investigation;Knock-out;LDL Cholesterol Lipoproteins;Light;Logic;Macrophage;Measurement;Measures;Molecular;monocyte;Mus;novel;novel therapeutic intervention;Other Genetics;oxidized low density lipoprotein;Pathway Analysis;Pathway interactions;Persons;Phenotype;phenotypic data;Population;Process;reverse cholesterol transport;Risk;Risk Reduction;Role;screening;Serum;small molecule;Therapeutic;tool;trait;transcription factor;Untranslated RNA;uptake;Variant;Work

PROJECT_TITLE: High-throughput investigation of human genetic variants affecting cholesterol uptake and efflux

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative This study will evaluate how sex (female, male) is associated with sensory perception, appeal, and reinforcing efficacy of e-cigarette flavors in nicotine containing e-cigarettes among adult smokers. Given the low rates of cessation among female compared male smokers and its potential relationship with non-nicotine sensory cues, this proposal will elucidate the role that perception of popular flavor components (sweet, cooling) plays in e- cigarette use, behavior, and abuse liability and how this role differs by sex. The outcomes of this project will provide the FDA with new information in key areas (Behavior, Addiction) to inform potential sex differences in response to e-cigarette flavor regulations with the aim of protecting overall public health.

PI_NAMEs: DAVIS, DANIELLE R (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Abstinence;abuse liability;addiction;Adult;Age;Area;Behavior;behavioral economics;career;career development;Cigarette;Cigarette Smoker;Clinical Trials;combustible tobacco;Coupled;Cues;Data Analyses;Dependence;design;Double-Blind Method;Electronic cigarette;electronic cigarette use;electronic liquid;Esthesia;Excision;experience;experimental study;Fellowship;Female;Funding;Gender;Goals;Grant;Harm Reduction;irritation;Literature;male;Manuscripts;meetings;Menopause;Menthol;Mentors;Nicotine;nicotine exposure;nicotine replacement;nicotine use;Outcome;Participant;Perception;Pilot Projects;Play;Population;Preparation;Psychological reinforcement;Psychologist;Psychophysics;Public Health;Regulation;reinforcer;reproductive;Research;Research Design;Research Project Grants;Research Training;response;Role;Schedule;Scientist;secondary analysis;Secondary to;Sensory;sex;sex as a biological variable;Sex Differences;skills;Smell Perception;Smoker;Smoking Behavior;smoking cessation;Taste Perception;Techniques;Tobacco;tobacco flavor;Tobacco Industry;tobacco products;tobacco regulatory science;Tobacco use;tobacco user;tool;Training;United States Food and Drug Administration;Woman;women versus men;Women's study;Work

PROJECT_TITLE: Sex Differences in E-Cigarette Flavor Sensory Perception As It Relates to Appeal and Reinforcing Efficacy Among Adult Smokers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-K(90)S]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Neurosciences

ORG_CITY: DAVIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE Myocardial infarction (MI, also known as a heart attack) predisposes patients to deadly cardiac arrhythmias (disturbances of the normal heart rhythm). Following MI, the sympathetic nerves in the heart undergo changes to their structure and function and these changes are associated with arrhythmias. But how exactly sympathetic nerve activity leads to arrhythmias after MI is unknown. The goal of this project is to determine the role of sympathetic nerve activity in leading to arrhythmias and to test how modulating nerve density or function may prevent arrhythmias following MI.

PI_NAMEs: RIPPLINGER, CRYSTAL MAY (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Action Potentials;Acute;Adrenergic Agents;Anti-Arrhythmia Agents;Apex of the Heart;Arrhythmia;Automobile Driving;Autonomic Dysfunction;Autonomic nervous system;base;Behavior;Cardiac;Cardiac Electrophysiologic Techniques;Cardiac Myocytes;Cardiovascular Diseases;Catecholamines;Chronic;Clinical;Complex;Cyclic AMP;Denervation;density;Dose;efficacy evaluation;Electrophysiology (science);fighting;Fluorescence Resonance Energy Transfer;Funding;Goals;Heart;heart rhythm;Heterogeneity;Image;imaging system;Impairment;Individual;insight;Ischemia;Kinetics;Lesion;Maintenance;Maps;Measures;Membrane;Methodology;Mus;Muscarinics;Myocardial Infarction;Nerve;Neurons;Neuropeptides;neuroregulation;Neurotransmitters;novel;novel strategies;optical imaging;Optics;Organ;Oryctolagus cuniculus;Output;Pathologic;Patients;Perfusion;pharmacologic;Physiological;prevent;Publishing;reinnervation;Reporter;response;Role;Signal Transduction;small molecule;spatiotemporal;Speed;Structure;Sudden Death;Sympathectomy;Testing;Time;tool;Translating;transmission process;Ventricular Arrhythmia

PROJECT_TITLE: Sympathetic remodeling and ventricular arrhythmia

STUDY_SECTION: ESTA

STUDY_SECTION_NAME: Electrical Signaling, Ion Transport, and Arrhythmias Study Section[ESTA]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Gene Therapy;Genetics;Immunotherapy;Nanotechnology;Prostate Cancer;Urologic Diseases

PHR: PROJECT NARRATIVE Prostate cancer (PCa) remains a serious social and economic burden, and the American Cancer Society (ACS) estimates 191,930 new cases and 33,330 deaths in the United States from this disease in 2020. This project aims to develop a novel mRNA delivery platform for effectively restoring tumor suppressor PTEN and inducing anti-tumor immune responses in PCa, which can also be combined with immune checkpoint blockade therapy for highly potent cancer treatment. We expect this research project will form the foundation for development of a new, rational combination therapy that could significantly extend the lives of PCa patients.

PI_NAMEs: SHI, JINJUN  (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: Address;Adjuvant;Aftercare;Agonist;American Cancer Society;Animal Model;antagonist;anti-PD1 antibodies;anti-PD1 therapy;anti-tumor immune response;Apoptosis;Autophagocytosis;Biodistribution;Biological Markers;Blood Circulation;cancer cell;Cancer Patient;cancer therapy;cancer type;Cells;Cessation of life;Charge;clinical development;Combined Modality Therapy;cytokine;cytotoxic;Cytotoxic T-Lymphocytes;cytotoxicity;Development;Disease;Drug Kinetics;Economic Burden;Encapsulated;Endosomes;Engineering;Excretory function;Face;Formulation;Foundations;Funding;Gene Expression;Generations;Genetically Engineered Mouse;Goals;Growth;HMGB1 gene;Hybrids;Immune;immune checkpoint;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;Immunocompetent;immunogenic cell death;Immunologic Memory;improved;In Vitro;in vivo;Individual;Induction of Apoptosis;Injections;Kidney;Light;Lipids;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Messenger RNA;Modality;Modeling;Molecular;Molecular Weight;mRNA delivery;Mus;Mutate;Mutation;nanomedicine;nanoparticle;nanoparticle delivery;nanotherapy;Nature;Neoplasm Metastasis;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;novel strategies;novel therapeutics;nuclease;Oncogenes;Pathway interactions;Pattern;Pharmaceutical Preparations;Phenotype;Polymers;Predisposition;Prevention;programmed cell death protein 1;prostate cancer cell;prostate cancer model;Prostate Cancer therapy;protein expression;PTEN gene;Regulatory T-Lymphocyte;Research Project Grants;restoration;RNA;RNA delivery;Role;Safety;Series;siRNA delivery;Small Interfering RNA;social;Solid Neoplasm;subcutaneous;Surface;System;T cell response;Technology;Testing;Therapeutic;Therapeutic Effect;TLR9 gene;TP53 gene;Transfection;Transgenic Model;Translations;tumor;Tumor Cell Line;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Suppressor Proteins;tumor-immune system interactions;United States;uptake;Validation;Work

PROJECT_TITLE: Systemic RNA Delivery to Tumors

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Rural Health

ORG_CITY: RICHMOND

ORG_DEPT: PEDIATRICS

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE Low-value care can result in patient harm and billions of dollars in unnecessary health care costs, yet little is known about the factors driving pediatric low-value care and how to best reduce harmful and unnecessary care being delivered to children. This proposal will study the individual and healthcare system factors associated with low-value care and survey providers about perceived barriers to de-implementation. The results will provide the foundation needed to test de-implementation strategies in real-world conditions.

PI_NAMEs: WOLF, ELIZABETH REBECCA  (contact)

PROGRAM_OFFICER_NAME: BROWN, PATRICK

PROJECT_TERMS: Academy;Accident and Emergency department;Adverse event;Affect;Age;Agreement;Ambulatory Care;American;Antacids;Antibiotics;Antimicrobial Resistance;Automobile Driving;Awareness;Bronchiolitis;Caring;Characteristics;Child;Child Care;Childhood;Classification;Clinical;clinical center;Clinical Research;clinical training;Code;Cognitive;cohort;Consolidated Framework for Implementation Research;cost;Data;Database Management Systems;Databases;Deimplementation;design;Diagnosis;Diagnostic;Education;evidence base;experience;Family;Family Practice;Feedback;Foundations;Fright;Future;Geographic Distribution;Goals;Grouping;Guidelines;Health Care Costs;Health Knowledge Attitudes Practice;Health Services Research;Healthcare Systems;High Prevalence;implementation framework;implementation intervention;implementation research;implementation science;implementation strategy;improved;Individual;Infant;Inpatients;insight;Insurance;Interview;Knowledge;Measures;Medical Care Costs;medical specialties;Mentorship;Mission;Modeling;Names;National Center for Advancing Translational Sciences;Outcomes Research;Outpatients;patient oriented;Patient-Focused Outcomes;Patients;Pattern;pediatrician;Pediatrics;Pharmaceutical Preparations;preference;prevent;programs;Provider;Race;Recommendation;Reflux;Research;Respiratory Tract Infections;Rural;rural area;rural residence;rurality;screening;Services;sex;Societies;statistics;Structure;suburb;Surveys;System;systemic barrier;Testing;therapy design;Translational Research;Translations;Uncertainty;Upper Respiratory Infections;urgent care;Viral;Virginia;Vitamin D

PROJECT_TITLE: UNderstanding the Delivery of Low-Value CAre To CHildren and the Barriers to De-Implementation (UN-LATCH)


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Pediatric;Prevention;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: NARRATIVE  Ascending thoracic aortic aneurysm (ATAA) is a highly lethal event because it renders the aorta vulnerable to dissection, which is the fifteenth leading cause of death in the United States. Due to a lack of understanding of ATAA at the cellular and molecular level, care of patients has been limited to open heart surgery only for advanced-stage aneurysm or for dissection. The two primary objectives of this proposal are to 1) better understand the biology of ATAA to uncover new therapeutic targets aimed at preserving aortic wall integrity and preventing aneurysm progression and 2) develop a multi-parameter, patient-specific (bio)image-based interrogation strategy to develop new diagnostic tools for early detection and better surveillance of ATAA.

PI_NAMEs: GLEASON, THOMAS GILLETTE (contact)

PROGRAM_OFFICER_NAME: REID, DIANE M

PROJECT_TERMS: 4D MRI;Acute;adjudication;Affect;Aneurysm;Angiography;Antioxidants;Aorta;aortic valve;Architecture;ascending aorta;base;bicuspid aortic valve;Biochemical;bioimaging;Biological;Biology;Biomechanics;Cardiac Surgery procedures;Caring;Cause of Death;cell injury;Clinical;clinical imaging;Clinical Trials;cohort;Collagen;Complex;Computer Models;congenital anomaly;Coupled;Data;design;diagnostic tool;Diameter;Dimensions;Disease;Disease Progression;Dissection;Early Diagnosis;Early Intervention;Echocardiography;efficacy testing;Elastin;Electrocardiogram;Etiology;Event;Exposure to;Extracellular Matrix;Free Radicals;Funding;General Population;Goals;Guidelines;Health;Hypoxia;Image;in vivo;indexing;Intervention;Maps;Measurement;Measures;mechanical force;mechanical properties;Mechanical Stress;Mechanics;Medial;Mediating;Medical;Modeling;Molecular;Natural History;new therapeutic target;Non-Invasive Detection;novel;novel diagnostics;Operative Surgical Procedures;Output;overtreatment;oxidative damage;Oxidative Stress;Oxidative Stress Induction;Oxidative Stress Pathway;Oxygen;Patient Care;patient population;Patient risk;Patients;Phase;Pimonidazole;Play;Positron-Emission Tomography;Predisposition;preservation;prevent;Preventive;Production;Publishing;Recommendation;response;Risk;scaffold;shear stress;Smooth Muscle Myocytes;Specimen;stem;Stress;stressor;Stretching;Superoxides;surgical risk;System;Testing;Therapeutic Intervention;Thoracic Aortic Aneurysm;three dimensional cell culture;Tissues;tool;United States;United States National Institutes of Health;uptake;Work;X-Ray Computed Tomography

PROJECT_TITLE: ROS Mechanisms in BAV Aortopathy

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Improvements in individual and public health depend on engaging and training a multidisciplinary cadre of scientists from multiple disciplines and with diverse perspectives and then encouraging and supporting them to come together in highly functioning teams to tackle important and unsolved problems in human and community health. Only then can we translate the explosion of new knowledge from basic biomedical research to actually develop the diagnostic procedures, preventive measures, treatments, and practice guidelines and policies to lessen the burden of disease and improve the health of every American, in every community, across the lifespan. We have developed, and seek to continue, a career development program for junior faculty scientists to enable them to contribute to this research.

PI_NAMEs: UMANS, JASON G (contact)

PROGRAM_OFFICER_NAME: BOUGH, KRISTOPHER J

PROJECT_TERMS: Acceleration;Address;Advisory Committees;American;Behavior;Biomedical Research;burden of illness;career;Career Choice;career development;clinical center;Clinical Data;Clinical Research;Clinical Sciences;Collaborations;Common Core;Communities;Community Health;Competence;Consultations;design;Development;Diagnostic Procedure;Discipline;Education;Educational Curriculum;Educational workshop;Eligibility Determination;Ensure;Ethnic Origin;Evaluation;experience;Explosion;Faculty;Frustration;Funding;Gender;Goals;Health;Health Benefit;health disparity;Home;Human;human disease;improved;Individual;Inosine Diphosphate;Institution;Knowledge;Lead;Leadership;life span;Mentors;Mentorship;Methods;Modeling;multidisciplinary;National Research Service Awards;new growth;novel;novel strategies;Outcome;Patients;Persons;Policies;Population;Positioning Attribute;Postdoctoral Fellow;Practice Guidelines;pre-doctoral;Preventive measure;Problem Solving;Process;Productivity;Program Development;programs;Public Health;Qualifying;Race;randomized, clinical trials;Research;Research Personnel;responsible research conduct;Science;Scientist;skills;Socialization;success;Testing;TNFSF15 gene;tool;Training;Training Programs;Translating;Translational Research;translational scientist;Translations;treatment guidelines;Universities;Work

PROJECT_TITLE: Institutional Career Development Core


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Gene Therapy;Genetics;Nanotechnology;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PISCATAWAY

ORG_DEPT: CHEMISTRY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Our proposed studies are relevant to public health, as developing a non-viral method to investigate mitochondrial dysfunction in neurodegeneration to facilitate CNS regeneration and prevent the pathophysiology of mitochondrial disease. Therefore, the proposed research is relevant to the part of NIH’s mission that relates to treating human illness and disability by investigating how innovative technology can safely translate to clinics.

PI_NAMEs: LEE, KIBUM  (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Address;Aftercare;base editing;Binding;biomaterial compatibility;Blood;Cells;Circulation;Clinic;Cytochrome c Reductase;cytotoxic;disability;Disease;DNA;DNA Binding;DNA delivery;DNA Sequence;Electron Transport;Face;factor A;Functional disorder;Gene Activation;gene editing technology;Gene Expression;Genes;Genetic;Genetic Diseases;genetic manipulation;Genetic Transcription;genome editing;Goals;Health;Human;human disease;immunogenic;Impairment;improved;Induced pluripotent stem cell derived neurons;injury and repair;innovation;innovative technologies;Knowledge;Ligands;Light;Link;Mediating;Methods;Mission;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial genome;Mitochondrial Proteins;mtTF1 transcription factor;Muscle;Mutation;NADH dehydrogenase (ubiquinone);nanobiomaterial;nanocluster;nanoGold;nanoparticle;Natural regeneration;Nerve Degeneration;Nerve Regeneration;Nervous System Disorder;neuron loss;Neurons;novel;Nuclear;nuclease;overexpression;Parkinson Disease;Pathology;patient derived induced pluripotent stem cells;Penetration;Peptides;Performance;prevent;Production;Proteins;Public Health;Quality of life;Radiation Protection;Reactive Oxygen Species;Research;scaffold;Site;small molecule;targeted delivery;Techniques;Technology;technology platform;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;tool;transcription factor;Transcriptional Regulation;Translating;Treatment Efficacy;United States National Institutes of Health;uptake;Viral;Viral Vector

PROJECT_TITLE: Investigating mitochondrial dysfunction in neurodegeneration using A Nanoparticle-based Synthetic Mitochondrial DNA (mtDNA) Transcription Regulator


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Arthritis;Bioengineering;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD);Osteoarthritis;Patient Safety;Physical Injury - Accidents and Adverse Effects

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Accurate reduction of joint dislocations is challenged by uncertainties in reckoning 3D anatomy from 2D imaging, extended use of fluoroscopy, and high risk of complications that can lead to poor functional outcomes, osteoarthritis, and disability. Proposed work develops an image-guided robotic approach to enable accurate repair of the ankle syndesmosis through automatic 3D planning, precise robotic execution, and intraoperative image-based confirmation. The solution combines modern robotics approaches with intraoperative imaging to satisfy the high technical demands of joint realignment, limit radiation dose to patient and staff, and provide accurate treatment to ultimately improve long-term patient outcomes.

PI_NAMEs: UNERI, ALI  (contact)

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: 3-Dimensional;Address;Affect;Algorithms;Anatomy;Ankle;Ankle Fracture;Area;arm;bone;Cadaver;Chronic;Clinical;Clinical Research;Clinical Trials;cone-beam computed tomography;Contralateral;cost;Debility;Degenerative polyarthritis;design;Devices;disability;Dislocations;Distal;Dose;Evaluation;experience;eye hand coordination;Fellowship;fibula;Fibula Fracture;first-in-human;Fluoroscopy;Fracture;Functional impairment;functional outcomes;high risk;Image;Image Analysis;image guided;image registration;Image-Guided Surgery;improved;Incidence;Injury;instrument;Joint Dislocation;Joints;long bone;long-term rehabilitation;Low Dose Radiation;Manuals;Mechanics;Methods;Modernization;Morbidity - disease rate;Morphology;multidisciplinary;Muscular Atrophy;novel;operation;Operative Surgical Procedures;Orthopedic Surgery;Orthopedics;Outcome;Pain;Patient-Focused Outcomes;Patients;Performance;Pilot Projects;Positioning Attribute;Preclinical Testing;Quality of life;Radiation;Radiation Dose Unit;radiological imaging;repaired;Reporting;Research;research clinical testing;restoration;Risk;Robot;robot assistance;robot control;robotic system;Robotics;Roentgen Rays;Role;safety and feasibility;safety assessment;sample fixation;Second Look Surgery;shape analysis;Side;skills;software development;Source;Specialist;Specimen;standard of care;success;Surgeon;System;Systems Integration;Techniques;Technology;Three-Dimensional Image;Three-Dimensional Imaging;Training;Translating;Trauma;trauma surgery;Traumatic Arthropathy;Uncertainty;Visualization;Work;X-Ray Medical Imaging

PROJECT_TITLE: Image-guided, robot-assisted reduction of joint dislocation in orthopaedic surgery


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE Women living with HIV are at increased risk of precancerous cervical intraepithelial neoplasia (CIN2/3) and standard treatment modalities for CIN2/3 are less effective in HIV-infected women. We propose to evaluate the acceptability, feasibility (safety, tolerability, adherence, retention), and preliminary efficacy of a combination treatment strategy (i.e., surgery followed by topical therapy with 5% 5-fluorouracil [5FU]) in order to improve cervical cancer prevention and long-term treatment outcomes in this high-risk population. If successful, our proposed combination strategy would have broad relevance for women living with HIV in both resource-rich and resource-poor regions worldwide, including rural and remote areas of the U.S.

PI_NAMEs: CHIBWESHA, CARLA J (contact);RAHANGDALE, LISA

PROGRAM_OFFICER_NAME: SAHASRABUDDHE, VIKRANT V

PROJECT_TERMS: Ablation;acceptability and feasibility;access disparities;Accounting;Address;Adherence;Adjuvant;Adjuvant Therapy;African;African Women;Aftercare;Area;Biopsy;cancer prevention;cancer therapy;Cervical;cervical cancer prevention;Cervical Cancer Screening;Cervical Intraepithelial Neoplasia;cervicovaginal;Cessation of life;Combined Modality Therapy;Community Health Education;Community Outreach;cost;cytokine;Disease;Disparity;Dose;efficacy evaluation;efficacy study;efficacy testing;Enrollment;Excision;experience;feasibility trial;Fluorouracil;Focus Groups;Frequencies;Generations;Generic Drugs;Genitalia;Genotype;Goals;Health;Health Personnel;high risk population;High Risk Woman;Histology;HIV;HIV-1;Human Papilloma Virus Vaccination;Human Papillomavirus;Immune;immune activation;Immune response;improved;Incidence;Inflammation;Inflammatory;Infrastructure;Interleukin-1 alpha;Interleukin-10;Interleukin-12;Interview;Investments;Lavage;lifetime risk;loop electrosurgical excision procedure;low and middle-income countries;male;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Measures;Mediating;Modality;mortality;novel;Nurses;Operative Surgical Procedures;Outcome;Participant;Patients;Perception;Placebos;Population;premalignant;prevent;Prevention strategy;primary outcome;Randomized;Recurrence;Reporting;Research;Resource-limited setting;Resources;Risk;Risk Reduction;RNA;Rural;Safety;secondary outcome;Self Administration;Series;Sexually Transmitted Diseases;South Africa;South African;Specimen;standard care;Testing;TNF gene;Treatment outcome;treatment strategy;trial enrollment;tumor-immune system interactions;Woman

PROJECT_TITLE: Acceptability and feasibility of combination treatment for cervical precancer among South Africa women living with HIV

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Patient Safety;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Screening and Brief Intervention for Substance Misuse;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE This timely study examines trends and predictors of unhealthy alcohol use among aging women (≥ age 50) in a large, diverse health care system, and how health services can reduce unhealthy use, with a particular focus on potential disparities for racial/ethnic minority women. We also interview patients, and providers who care for them, to gain a deeper understanding of aging women’s needs, and potential treatment strategies. Findings will inform how health systems can address unhealthy alcohol use among aging women, a critical growing clinical and public health problem.

PI_NAMEs: CAMPBELL, CYNTHIA I (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: addiction;Address;Adherence;adverse outcome;Affect;Age;age difference;age group;Age Years;Aging;aging population;Alcohol abuse;Alcohol consumption;alcohol effect;alcohol intervention;alcohol misuse;alcohol screening;alcohol use disorder;Alcohols;anti-depressive agents;Anti-Hypertensive Agents;Anxiety;baby boomer;barrier to care;Benzodiazepines;binge drinking;brief alcohol intervention;brief intervention;care systems;Caring;Caucasians;causal model;chronic pain;Clinical;clinical diagnostics;clinical risk;Comprehensive Health Care;Data;Diabetes Mellitus;Discipline of obstetrics;Disparity;drinking;early alcohol use;effective intervention;Electronic Health Record;ethnic difference;Ethnic Minority Women;Ethnic Origin;Ethnic Population;Exercise;experience;Face;follow-up;Funding;Geriatrics;Guidelines;Gynecology;Health;Health behavior;health care delivery;health care service utilization;Health Personnel;health service use;Health Services;Health Services Accessibility;Health system;Healthcare;Healthcare Systems;high risk;holistic approach;human old age (65+);Hypertension;Hypoglycemia;improved;indexing;Individual;innovation;Interpersonal Violence;intersectionality;Intervention;Interview;Medical;medical specialties;Medicine;member;men;Mental Depression;Methods;middle age;Modeling;National Institute on Alcohol Abuse and Alcoholism;older adult;Older Population;older women;Opioid;Pain;Patient Self-Report;Patients;people of color;Pharmaceutical Preparations;prescription opioid;Primary Care;primary care visit;Provider;Psychiatric Diagnosis;Psychiatry;Public Health;Race;racial difference;racial disparity;racial minority women;racial population;Recommendation;reduced alcohol use;Registries;Reporting;Research;Research Priority;Risk;Risk Factors;Role;screening;screening program;Services;System;Testing;theories;Time;Tobacco;treatment strategy;trend;United States;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Role of Health Care in Addressing Unhealthy Alcohol Use and Disparities among Aging Women


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: PHYSIOLOGY

PHR: Alzheimer’s disease (AD) is the most common form of dementia and is characterized by a progressive cognitive decline and neuronal dysfunction. Although it is widely accepted that the functional failures of synapses are the initial events leading to the disease, the mechanisms that drive those failures remain poorly understood. Proper cognitive function requires an intricate balance between inhibitory and excitatory synaptic transmission. By understanding how this balance in dysregulated in AD, this study will reveal novel therapeutic targets for restoring synaptic dysfunction at the early stages of the disease.

PI_NAMEs: HOYOS-RAMIREZ, ERIKA  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Amyloid beta-Protein;Behavior;Businesses;career;career development;Cells;Characteristics;Chemosensitization;Chronic;CNR1 gene;Cognition;Cognition Disorders;Cognitive;cognitive function;commercialization;Defect;Dementia;Development;Development Plans;Disease;disease model;Disinhibition;Down-Regulation;Electroencephalography;Entrepreneurship;Equilibrium;Etiology;Event;Exhibits;Failure;Functional disorder;Goals;Hippocampus;Impaired cognition;innovation;Institution;Measures;Mediating;Mentors;mouse model;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuronal Dysfunction;Neurons;neuropathology;Neurosciences;Neurosciences Research;new therapeutic target;novel;novel therapeutics;Parietal Lobe;Patients;pharmacologic;Pharmacotherapy;presynaptic;prevent;Research;Research Activity;Role;Senile Plaques;Signal Transduction;Symptoms;Synapses;synaptic failure;synaptic function;Synaptic Transmission;Temporal Lobe;Testing;Therapeutic;therapeutic development;therapeutic target;Training;Translating;translational neuroscience;transmission process

PROJECT_TITLE: Revealing roles of heterosynaptic plasticity in Alzheimer's disease


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Eye Disease and Disorders of Vision;Genetics;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PHR: PROJECT NARRATIVE GBM is an incurable disease associated with invariable recurrence despite aggressive therapy with DNA damaging temozolomide and radiation. The focus of this application is to better understand how two specific proteins (RBBP4/p300) interacts to regulate DNA damage response genes that may contribute to the intractable nature of GBM. Ultimately, these studies may identify novel therapeutic strategy that can significantly enhance the efficacy of chemotherapy and/or radiation.

PI_NAMEs: KITANGE, GASPAR JULIUS (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Acetylation;adduct;aggressive therapy;Animal Model;BARD1 gene;Binding;Biological Assay;BRCA1 gene;BRD2 gene;Bromodomain;Bromodomains and extra-terminal domain inhibitor;c-myc Genes;Cells;chemotherapy;Chemotherapy and/or radiation;Chromatin;Clinical;Clinical Trials;clinically relevant;Co-Immunoprecipitations;Complex;cytotoxicity;Data;design;Disease;DNA Damage;DNA Double Strand Break;DNA Methylation;DNA Repair;DNA replication fork;efficacy testing;Enhancers;EP300 gene;Epigenetic Process;Failure;Family;Family member;Gene Expression;gene product;Genes;Genetic;Genetic Enhancer Element;Genetic Transcription;Glioblastoma;glioma cell line;Goals;Histone Acetylation;histone acetyltransferase;Histones;homologous recombination;Impairment;in vivo;inhibitor;insight;knock-down;Lesion;Ligation;Link;Mediating;Modeling;Nature;Newly Diagnosed;Normal Cell;Normal tissue morphology;novel;novel therapeutic intervention;Oncology;PARP inhibition;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Play;Poly(ADP-ribose) Polymerase Inhibitor;Process;promoter;Promoter Regions;protein expression;Protein Family;protein function;Proteins;Radiation;Reader;Recovery;recruit;Recurrence;Recurrent disease;Regulation;Regulatory Pathway;repaired;Reporting;Research;research clinical testing;response;Retinoblastoma;RNA Polymerase II;Role;Series;small hairpin RNA;temozolomide;Tertiary Protein Structure;Testing;Therapeutic;Time;tool;transcription factor;treatment response;tumor;Tumor Tissue

PROJECT_TITLE: Role of RBBP4/p300 Complex in Recovery from therapy induced DNA damage in glioblastoma

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cannabidiol Research;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Endocannabinoid System Research;Natural Products;Neurodegenerative;Neurosciences;Pain Research;Prevention;Sleep Research;Therapeutic Cannabinoid Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Research Narrative Use of cannabidiol (CBD) has been increasing rapidly across the United States, particularly among adults over the age of 55 with mild cognitive impairment and who might be at risk for Alzheimer’s disease (AD). The proposed randomized, placebo-controlled, double-blind trial will examine the effect of CBD biomarkers and behavioral measures associated with the progression of AD over 6 months. The information gained in this research is expected to inform public health about the effects of CBD in this population.

PI_NAMEs: BRYAN, ANGELA ;HUTCHISON, KENT E. (contact)

PROGRAM_OFFICER_NAME: RYAN, LAURIE M

PROJECT_TERMS: Address;Adult;Age;aging population;Alzheimer's Disease;Alzheimer's disease risk;Amyloid beta-42;Amyloid beta-Protein;Animals;Anti-Inflammatory Agents;Anxiety;behavior measurement;Biological Markers;Cannabidiol;Cannabinoids;Cognition;Cognitive;Colorado;Controlled Clinical Trials;Data;Dementia;design;Dose;Double-Blind Method;double-blind placebo controlled trial;Down-Regulation;economic cost;Endocannabinoids;epidemiologic data;Health;Hemp;high risk;human old age (65+);Hydroxyeicosatetraenoic Acids;Impaired cognition;improvement on sleep;Individual;Inferior;Inflammation;Inflammatory;Journals;Light;Link;Lipids;Marketing;Measures;Mediating;Mental Depression;mild cognitive impairment;Morbidity - disease rate;mortality;negative affect;Nerve Degeneration;neurofilament;neuroprotection;older adult;Outcome;Outcome Measure;Oxidative Stress;Pain;Pain interference;Pain Measurement;Patients;Placebo Control;Placebos;Plasma;Population;pre-clinical;Prevalence;prevent;primary outcome;progression marker;Property;Prostaglandin D2;Public Health;public health research;Publishing;Randomized;randomized placebo controlled trial;Research;secondary outcome;Signal Transduction;Sleep;Sleep disturbances;sleep quality;sleep quantity;socioeconomics;Surveys;tau-1;Testing;Time;trend;United States;Up-Regulation;Work

PROJECT_TITLE: Cannabidiol for Individuals at Risk for Alzheimer's Disease: A Randomized Placebo Controlled Trial


ADMINISTERING_IC: HD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: CHARLESTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: OVERALL – PROJECT NARRATIVE The National Center of Neuromodulation for Rehabilitation (NC NM4R) at the Medical University of South Carolina (MUSC) addresses the critical need for focused rehabilitation research infrastructure to support rigorous clinical research and to translate non-invasive neuromodulation for rehabilitation reserach approaches into effective, evidence-based interventions. The Center has become an integrated system for training researchers across the spectrum from postdocs to senior investigators, enabling critical data collection via pilot awards, advancing careers and extramural grant applications through mentored collaborative consultations, convening world leaders in the field to discuss methods and technology, and enhancing rigor and reproducibility through hands-on workshops culminating in a research-ready workforce. In the renewal, we will enhance our strategies to closely align with the priority areas indentified in the NIH Research Plan for Rehabilitation.

PI_NAMEs: KAUTZ, STEVEN A. (contact)

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: Address;Affect;Alabama;Animal Model;Applications Grants;Area;Award;Behavior;Belief;Brain;Career Mobility;career preparation;Centers of Research Excellence;Childhood;Clinical;Clinical Research;Clinical Trials;Collaborations;Combined Modality Therapy;Communities;Consultations;Data;Data Collection;design;Development;Educational workshop;Ensure;Equipment Design;ethnic diversity;Evaluation;evidence base;Evidence based intervention;Evidence based treatment;Exposure to;Extramural Activities;Failure;Functional Magnetic Resonance Imaging;Funding;Future;Gender;Goals;Grant;Image;improved;Infant;insight;Institution;Intervention;Journals;Measurement;Medical;Medicine;Mentors;Methods;Modeling;multidisciplinary;National Institute of General Medical Sciences;Nervous System;network models;neural circuit;Neuronal Plasticity;neuroregulation;next generation;novel;Operant Conditioning;Paper;Peer Review;Population;Postdoctoral Fellow;Process;programs;Psychiatry;Publishing;Race;rehabilitation research;Rehabilitation therapy;Reproducibility;Research;Research Design;Research Infrastructure;Research Methodology;Research Personnel;Resources;Site;skills;South Carolina;Spinal;Standardization;stroke recovery;success;Systems Integration;Techniques;Technology;technology development;Testing;tool;Training;Translating;Translational Research;United States National Institutes of Health;Universities;Vision;Work


NIH_SPENDING_CATS: Behavioral and Social Science;Complementary and Integrative Health;Neurosciences;Physical Rehabilitation;Rehabilitation

PI_NAMEs: SEGAL, RICHARD L (contact)

PROJECT_TERMS: Active Learning;Address;Applications Grants;Area;Brain;career;clinical translation;Collaborations;Combined Modality Therapy;Communities;community collaboration;Creativeness;Dedications;design;Educational Curriculum;Educational workshop;evidence base;experience;Extramural Activities;Feedback;Foundations;functional magnetic resonance imaging/electroencephalography;Funding;Future;Grant;Guidelines;hands-on learning;improved;innovation;Instruction;interest;Intervention;Knowledge;laboratory experience;Leadership;Learning;lectures;meetings;member;Mentors;Methodology;Methods;National Institute of Mental Health;neurological rehabilitation;neuroregulation;new technology;novel;online repository;Operant Conditioning;Participant;Phase;programs;Psychological reinforcement;rehabilitation research;Rehabilitation therapy;Reproducibility;Research;Research Personnel;Resources;Safety;Schedule;skills;success;symposium;Techniques;Technology;technology development;Testing;theories;tool;Training;training opportunity;Translating;United States National Institutes of Health;web site

PROJECT_TITLE: Didactic Interactions


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Complementary and Integrative Health;Neurosciences;Physical Rehabilitation;Rehabilitation

PI_NAMEs: THOMPSON, AIKO  (contact)

PROJECT_TERMS: Address;Applications Grants;Area;Award;Biometry;Clinical Research;Collaborations;Collection;Consult;Consultations;Critiques;Data Collection;design;Development;Discipline;Educational workshop;evidence base;experience;Extramural Activities;Faculty;Financial Support;Funding;Goals;Grant;hands on research;Infrastructure;Institution;interest;Intervention;investigator training;Laboratories;Learning;Link;Manuscripts;Marketing;Medical;meetings;member;Mentors;Mentorship;Methods;neuroimaging;neuroregulation;novel;Outcome;Participant;Pilot Projects;programs;Publications;Qualifying;Recording of previous events;recruit;rehabilitation research;Rehabilitation therapy;Remunerations;Research;Research Design;Research Personnel;Resources;Schedule;Science;Scientist;Services;Site;skill acquisition;skills;South Carolina;success;symposium;Testing;theories;tool;Training;Training Programs;Translating;United States National Institutes of Health;Universities;Videoconferencing;virtual;Visit;web portal

PROJECT_TITLE: Mentored Collaborative Opportunities


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: ANN ARBOR

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The Michigan Vision Clinician-Scientist Development Program develops ophthalmologists who can further our understanding of vision and its preservation. This mentored research training program provides the foundational resources for scholars to build their research programs and mature into independent investigators who will contribute to new knowledge and therapies and inspire future young clinicians, researchers, and clinician-scientists.

PI_NAMEs: LEE, PAUL P;ZACKS, DAVID N (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Achievement;Address;career;Clinical Trials;Collaborations;Dedications;design;Disease;Effectiveness;Health;Health Services;improved;interdisciplinary approach;Measures;Mentors;Michigan;Mission;multidisciplinary;Patients;Personal Satisfaction;Productivity;Program Development;programs;Research;Research Personnel;Resources;Science;Scientific Advances and Accomplishments;Scientific Inquiry;Scientist;Strategic Planning;success;Time;Translating;Universities;Vision;Vision research;Visual System

PROJECT_TITLE: Michigan Vision Clinician Scientist Development Program


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Neurosciences;Physical Rehabilitation;Rehabilitation

PI_NAMEs: GEORGE, MARK S (contact)

PROJECT_TERMS: Address;Brain;catalyst;Childhood;Clinical Research;Clinical Trials;Communities;community engagement;design;Development;Dose;effective therapy;Elements;Enhancement Technology;Equilibrium;Evaluation;evidence base;Evidence based intervention;Feedback;functional magnetic resonance imaging/electroencephalography;Funding;Future;Gait;Goals;improved;Individual;Intervention;Knowledge;Leg;Mainstreaming;Mental Depression;method development;Methodology;Methods;Motor;Multi-Institutional Clinical Trial;Neurologic;neurophysiology;neuroregulation;noninvasive brain stimulation;novel therapeutics;Operant Conditioning;Performance;Population;Process;Psychiatry;rehabilitation research;Rehabilitation therapy;Reproducibility;Research;research and development;Research Personnel;research study;Research Technics;Resources;response;Series;Site;Spinal Cord;Standardization;technique development;Techniques;technology development;Technology Development Study;technology/technique;Testing;tool;Translating;translational neuroscience;United States National Institutes of Health;Work

PROJECT_TITLE: Techniques Development


NIH_SPENDING_CATS: Clinical Research;Complementary and Integrative Health;Neurosciences;Physical Rehabilitation;Rehabilitation

PI_NAMEs: BOGER, HEATHER A (contact)

PROJECT_TERMS: Applications Grants;Archives;Area;Award;Clinical Research;Clinical Trials;cohort;Communities;community engagement;Complement;Consult;Consultations;Data;Data Analyses;design;Discipline;Doctor of Philosophy;Educational workshop;Evaluation;evidence base;Evidence based intervention;Extramural Activities;follow-up;Funding;Future;Goals;Home;Institution;Intervention;investigator training;Investments;member;Mentors;Methods;Mission;Modification;neuroregulation;Peer Review;Performance;Pilot Projects;Population;Preparation;Process;programs;Publications;Publishing;rehabilitation research;Rehabilitation therapy;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Resources;response;Series;Services;skills;success;symposium;Techniques;Technology;Time;tool;Training;Translating;translational potential;United States National Institutes of Health;web portal;Work

PROJECT_TITLE: Pilot Studies


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Pediatric;Prevention;Rehabilitation;Substance Misuse

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: R.220.8. Project Narrative Relevance to Public Health: Substance use disorders among youth present a tenacious public health problem and despite considerable advances in the development of efficacious treatments, novel treatments are sorely lacking. Interventions that emphasize cognitive-behavioral skills building and address motivation, but also continuing care and social recovery capital, such as the combined, Integrated Treatment for Enhancing Growth in Recovery during Adolescence (InTEGRA), show promise in helping sustain remission in cost-effective ways but need testing in larger samples for appropriateness and efficacy. Using a hybrid type I effectiveness-implementation-design, this study tests the efficacy, mechanisms, and moderators of the promising developmentally appropriate InTEGRA treatment for adolescents while investigating facilitators and barriers to widespread implementation.

PI_NAMEs: KAMINER, YIFRAH ;KELLY, JOHN F. (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: Abstinence;Achievement;Acute;Address;Administrator;Adolescence;Adolescent;Adoption;Adult;Age;Alcohol or Other Drugs use;Alcoholics Anonymous;Alcohols;base;behavior change;Behavioral;Behavioral Mechanisms;biobehavior;Capital;care episode;Caring;Clinic;Clinical;clinical research site;Cognitive;Cognitive Therapy;cohort;Combined Modality Therapy;Communities;Complex;coping;cost effective;cost effective treatment;Development;Diagnosis;Disease;Disease remission;Drug Use Disorder;effective therapy;effectiveness/implementation design;effectiveness/implementation hybrid;efficacious treatment;efficacy testing;Elements;emerging adulthood;Environment;experience;follow-up;Funding;Growth;Health Care Costs;high risk;Hybrids;implementation barriers;implementation design;implementation facilitators;Impulsivity;Intervention;intervention effect;Intervention Studies;Investigation;Link;Manuals;meetings;Modeling;Morbidity - disease rate;Motivation;motivational enhancement therapy;Narcotics Anonymous;Neurocognitive;novel;Outcome;peer;Persons;Pharmaceutical Preparations;Phase;Pilot Projects;Premature Mortality;Process;programs;prolonged abstinence;Provider;Public Health;Randomized;Recovery;recovery services;Recovery Support;resilience;Resources;response;Risk;Sampling;Science;Self Efficacy;Severities;Site;skills;social;Social Change;Social Network;Substance Use Disorder;support network;System;Testing;Therapeutic;Time;United States National Institutes of Health;Work;Youth

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Immunology is an interdisciplinary science with direct relevance to many human diseases, including infectious diseases, autoimmune diseases, inflammatory diseases, immunodeficiency diseases and cancer. The training of immunology-focused researchers will meet a growing challenge to understand and exploit the immune system to treat human disease. The Immunology, Inflammation and Infectious Disease (3i) Training Program will guide the development of the next generation of immunology researchers with the appropriate experience and knowledge to meet this challenge.

PI_NAMEs: LAMB, TRACEY JANE (contact);WILLIAMS, MATTHEW A

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TITLE: Cross-disciplinary Training in Immunology, Inflammation and Infectious Disease

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Behavioral and Social Science;Complementary and Integrative Health;Disability Research;Neurosciences;Physical Rehabilitation;Rehabilitation

PROJECT_TERMS: Address;Applications Grants;Archives;Area;Clinical Research;Collaborations;Communication;Communication Tools;Communities;community engagement;Complex;Data;Development;Disability research;Diverse Workforce;Education;Educational workshop;effective therapy;Electroencephalography;Ensure;ethnic diversity;evidence base;experience;Exposure to;Faculty;Functional Magnetic Resonance Imaging;Funding;Gender;Goals;Home;improved;Institution;International;Internet;Intervention;Journals;Leadership;Life Cycle Stages;live stream;Mental disability;Mental Health;Mentors;National Institute of Mental Health;neuroregulation;novel;outreach;outreach program;Paper;Performance;programs;Race;rehabilitation research;rehabilitation science;Rehabilitation therapy;repository;Research;Research Personnel;Resources;Science;Services;Software Tools;special interest group;Strategic Planning;Stream;success;symposium;Techniques;tool;Translating;translational engagement;translational scientist;Translations;United States National Institutes of Health;virtual;web portal;webinar;Work

PROJECT_TITLE: Promoting Center Expertise


PROJECT_TERMS: Accountability;Admission activity;Budgets;Collaborations;Communication;Communities;Conflict of Interest;Consultations;Decision Making;design;Development;Education;Educational workshop;Ensure;Evaluation;experience;Feedback;Funding;Goals;improved;Individual;Infrastructure;Investments;Leadership;Maps;Medical;member;Monitor;neuroregulation;operation;organizational structure;Pilot Projects;Policies;Process;Program Evaluation;programs;Quality Control;recruit;Regulation;rehabilitation research;Rehabilitation therapy;Reporting;Research;Research Personnel;Research Priority;Resources;retention rate;Running;Scientist;Services;sound;South Carolina;Strategic Planning;success;Supervision;Training Programs;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Administrative Oversight


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Back Pain;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Disability Research;Health Services;Opioids;Pain Research;Primary Health Care;Rehabilitation

ORG_CITY: DURHAM

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: DUKE UNIVERSITY

PHR: This proposal will assess the capacity of Health Care Systems to move guideline-based care of low back pain (LBP) to the forefront of the patient experience by rigorously evaluating a Multidisciplinary Conservative Care Model that utilizes doctors of chiropractic and physical therapists as the first point of contact for patients with LBP. The results from this study will directly inform implementation and policy efforts to improve the quality of pain management for patients suffering from LBP while simultaneously reducing opioid prescriptions, health care costs and utilization of services.

PI_NAMEs: CHAKRABORTY, HRISHIKESH  (contact)

PROGRAM_OFFICER_NAME: MURRAY, PETER DANIEL

PROJECT_TERMS: Age;Ambulatory Care;American;American College of Physicians;Caring;Categories;Chronic low back pain;chronic pain;Clinic;Clinical;Clinical Research;clinical trial protocol;Clinical Trials Data Monitoring Committees;Clinical Trials Design;Cluster randomized trial;Collaborations;collaborative care;Communities;comparative effectiveness;compare effectiveness;cost;Data;Data Collection;Data Coordinating Center;data dissemination;data management;data quality;Data Set;design;disability;Doctor of Chiropractic;effectiveness evaluation;electronic data capture system;Electronics;Ensure;Epidural Injections;Exercise;experience;Feasibility Studies;future implementation;Goals;Guidelines;Health Care Costs;health care service utilization;Health system;Healthcare Systems;implementation facilitation;implementation trial;improved;Infrastructure;innovation;Intervention;Iowa;Link;Low Back Pain;Manuscripts;Medical;Medical Care Costs;Medical center;meetings;member;Methods;Modeling;Monitor;multidisciplinary;Musculoskeletal;Musculoskeletal Pain;Non-Steroidal Anti-Inflammatory Agents;Nonpharmacologic Therapy;Online Systems;Opioid;opioid epidemic;opioid mortality;opioid use;Organizational Policy;Outcome;Pain;Pain interference;Pain management;pain patient;Pain quality;pain reduction;Patient Care;Patients;Phase;Physical Function;physical therapist;Physicians;Pilot Projects;Policies;pragmatic trial;Preparation;prescription opioid;primary care provider;Procedures;process evaluation;Provider;public repository;Publications;randomized, clinical trials;Recommendation;Reporting;Research;Research Institute;Research Personnel;Resources;Risk;Safety;secondary endpoint;service utilization;Source;Spinal Fusion;Spinal Manipulation;standard care;Statistical Data Interpretation;System;Techniques;Time;Training;treatment as usual;Universities;Visit;web site;Work

PROJECT_TITLE: 2/2: IMPACt-LBP DCC


NIH_SPENDING_CATS: Complementary and Integrative Health;Neurosciences;Physical Rehabilitation;Rehabilitation

PROJECT_TITLE: Coordinating Center


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative/Relevance We propose research on transfer learning methods for the digital curation of a key biomedical asset – the clinical narrative as part of the Electronic Medical Record. This research is in line with the latest developments in neural deep learning approaches and artificial intelligence in general and is expected to enhance biomedical research and through that the health of the public.

PI_NAMEs: SAVOVA, GUERGANA K. (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Adverse event;Apache;Appearance;Area;Artificial Intelligence;autism spectrum disorder;Automated Annotation;base;Biomedical Research;Brain Aneurysms;Classification;Clinical;Clinical Investigator;Communities;comorbidity;Computer Vision Systems;Computerized Medical Record;computing resources;Coupled;Creativeness;Data;Data Science;Data Set;Databases;deep learning;deep neural network;Development;digital;Disease;Engineering;Epigenetic Process;Evaluation;Event;Explosion;Genetic;Health;Hepatotoxicity;Image;imaging Segmentation;improved;informatics tool;Information Retrieval;Intuition;Investigation;Label;Language;Learning;learning strategy;Machine Learning;machine learning method;Medicine;Methodology;Methods;Methotrexate;Modeling;Multiple Sclerosis;multitask;Natural Language Processing;neural;neural network;Neural Network Simulation;next generation;novel;open source;Patients;Performance;Pharmaceutical Preparations;Phenotype;phenotypic data;pre-trained model;pre-trained transformer;Procedures;Public Health;Publications;Publishing;Rare Diseases;Reporting;Research;Resources;response;Rheumatoid Arthritis;Running;Semantics;Severities;Source;Speech;Structure;support vector machine;Symptoms;System;Techniques;Testing;Text;Time;Training;transfer learning;Translational Research;unstructured data;Vision;Work

PROJECT_TITLE: Transfer Learning for Digital Curation of the EMR Clinical Narrative


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Nutrition

ORG_DEPT: NUTRITION

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative We propose to continue a training program that will prepare outstanding individuals for a research career in nutritional sciences. This program brings together the faculty and physical resources of Harvard TH Chan School of Public Health and Harvard Medical School to provide multidisciplinary didactic and research experiences that transcend traditional specialty boundaries. Training positions are requested for individuals pursuing doctoral degrees in nutrition and for persons who have recently graduated and are seeking postdoctoral training.

PI_NAMEs: DUGGAN, CHRISTOPHER P;HU, FRANK B (contact)

PROGRAM_OFFICER_NAME: KAMARA, FANTA

PROJECT_TERMS: Grant;nutrition;Training

PROJECT_TITLE: TRAINING GRANT IN ACADEMIC NUTRITION


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Prevention;Substance Misuse

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: RELEVANCE (See instructions): This project will help elucidate the action of serotonergic psychedelics at the level of neural circuits and large-scale brain networks. Knowledge of these neural mechanisms may help prevent the recreational misuse of such drugs, as well as guide their safe use as potential therapeutics for neuropsychiatric disorders.

PI_NAMEs: MAZZUCATO, LUCA  (contact);NIELL, CRISTOPHER M

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: Affect;Agonist;Animals;Area;Back;Behavioral;Brain;Calcium;cell type;Cells;Code;Collaborations;design;Desire for food;Development;Electrophysiology (science);Equilibrium;expectation;experimental study;flexibility;Functional Magnetic Resonance Imaging;Glutamates;Hallucinations;Hallucinogens;HTR2A gene;Human;Image;Instruction;Knowledge;Link;Literature;Mediating;Modeling;Mood Disorders;Motivation;Mus;neural;neural circuit;neuromechanism;neuronal excitability;Neurons;neuropsychiatric disorder;neuroregulation;optogenetics;Paint;Pathway interactions;Perception;Pharmaceutical Preparations;Play;Population;predictive modeling;prevent;Pyramidal Cells;Recreation;Recurrence;response;Rewards;Role;Schizophrenia;Sensory;Series;Serotonin Receptor 5-HT2A;spatiotemporal;Statistical Methods;Stimulus;Structure;Testing;Theoretical model;theories;Therapeutic;Time;Training;Visual;Visual Cortex;Visual evoked cortical potential;visual processing;visual stimulus;Work

PROJECT_TITLE: CRCNS: A mechanistic theory of serotonergic modulation of cortical processing


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Nutrition;Obesity;Racial and Ethnic Minority Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Heart failure rates are rising globally, and the more common form of heart failure (called heart failure with preserved ejection fraction, HFpEF) has no available treatments. We propose to study South Asians, a unique group that has high rates of diabetes even with normal body weight, to understand how and why individuals develop heart failure. Studying diverse populations broadens our understanding of heart failure and will shed light into new treatments for HFpEF.

PI_NAMEs: KANAYA, ALKA M. (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Abdomen;Adenosine;Adult;Affect;Age;aptamer;arterial stiffness;Asian;Asian population;Atherosclerosis;Biological;Blood;Body mass index;Body Weight;Cardiac;cardiovascular disorder risk;Cardiovascular system;Cell surface;Central obesity;Classification;cohort;Coronary;Development;Diabetes Mellitus;diabetic;Echocardiography;EFRAC;endothelial dysfunction;Endothelium;Enzyme-Linked Immunosorbent Assay;Epidemiology;ethnic difference;Ethnic Origin;Ethnic Population;Exercise;experimental study;Fatty acid glycerol esters;Female;Glucose Intolerance;Goals;Heart Abnormalities;Heart failure;Heart Rate;Hepatic;High Prevalence;high risk;human old age (65+);Hypertension;hypertensive;Immunologics;improved outcome;Individual;Inflammation;Insulin Resistance;Knowledge;lens;Light;Link;Liver;Mass Spectrum Analysis;Measures;Mechanics;Mediating;Mediator;Metabolic;Metabolic dysfunction;Methods;Microvascular Dysfunction;Molecular;Morbidity - disease rate;mortality;Multi-Ethnic Study of Atherosclerosis;Muscle;Non obese;novel;novel therapeutics;Obesity;Participant;Pathogenesis;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Phenotype;Physiological;Plasma;Population;Population Heterogeneity;Prediabetes syndrome;preservation;Prevalence;prevent;Process;Prognosis;Prospective cohort;Proteins;proteomic signature;Proteomics;Protocols documentation;racial diversity;racial population;Risk Factors;Role;Sampling;sex;single-cell RNA sequencing;South Asian;Stress;Stress Echocardiography;Subgroup;Symptoms;Testing;tool;Viscera;Visceral fat;Weight

PROJECT_TITLE: Metabolic effects and mechanisms for heart failure in South Asians

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Digestive Diseases;Endocrine Disruptors;Estrogen;Genetics;Liver Disease;Nutrition;Obesity;Women's Health Research

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Exposure to dioxin and related ubiquitous environmental pollutants comprises a persistent human health risk to the general population. Comprehending how these pollutants alter the normal biological events that trigger the deleterious toxic outcomes including obesity and related metabolic disorders, requires a detailed understanding of the molecular processes. This application proposes studies examining the genomic signaling processes affecting expression of an important liver-derived metabolic hormone.

PI_NAMEs: WRIGHT, CASEY W (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Affect;Architecture;ARNT gene;ARNTL gene;Aromatic Polycyclic Hydrocarbons;Aryl Hydrocarbon Receptor;Binding Sites;Biological;Brain;Brown Fat;carbohydrate metabolism;Cell Line;Cell Separation;Cells;Chemicals;Chromatin;circadian;Circadian Rhythms;clinical development;combat;conditional knockout;Cues;Deposition;Development;diet-induced obesity;Dioxins;Disparate;Electron Transport;Environmental Pollutants;estrogenic;Estrogens;Event;Exhibits;Exposure to;Female;FGF21 gene;fibroblast growth factor 21;Gene Expression;General Population;Genes;Genomics;Glucagon;Glucocorticoids;Gonadal Steroid Hormones;Health;Hepatic;Hepatocyte;hepatoma cell;High Fat Diet;Homeostasis;Human;improved;in vivo;Insulin;Intervention;Knockout Mice;Ligands;lipid metabolism;Liver;Mediating;member;Metabolic;Metabolic Diseases;Metabolic hormone;Mitochondria;Molecular;Mus;Muscle;Mutate;novel strategies;Obesity;Outcome;Ovariectomy;Pathway interactions;Periodicity;Phase;Phenotype;Physiological;Physiological Processes;pollutant;preservation;prime editing;Process;promoter;Property;Protein Family;Proteins;receptor expression;Receptor Signaling;reconstitution;Regulation;Reporting;Research;Respiration;response;Response Elements;Risk;sexual dimorphism;Signal Transduction;single-cell RNA sequencing;single-minded protein;Somatotropin;Stat5 protein;success;Suggestion;Tertiary Protein Structure;Testing;Tetrachlorodibenzodioxin;Therapeutic;Thermogenesis;Thyroid Hormones;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;transcriptomics;Transfection;Variant;Xenobiotics

PROJECT_TITLE: Hepatic Aryl Hydrocarbon Receptor Regulation of Obesity: Mechanisms of Action

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative Macrophages remember prior microbial encounter to efficiently fight future infection. Zinc homeostasis is important for macrophage immunity to the fungus, Histoplasma capsulatum. We will explore how zinc metabolism shapes macrophage memory and how these macrophages resist this fungal pathogen.

PI_NAMEs: DEEPE, GEORGE S. (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Abbreviations;Acquired Immunodeficiency Syndrome;adaptive immunity;anti-fungal agents;antimicrobial;Attention;B-Lymphocytes;beta-Glucans;Binding Proteins;Biology;Bone Marrow;Candida albicans;Cells;Colony-forming units;constriction;Coupled;cytokine;Cytokine Activation;Defect;Development;Effector Cell;Elements;Epigenetic Process;Exhibits;fighting;Flow Cytometry;FRAP1 gene;fungus;Future;Glycolysis;Goals;Grant;Granulocyte-Macrophage Colony-Stimulating Factor;Growth;Histoplasma;Histoplasma capsulatum;Homeostasis;Human;Hypoxia;Immune response;Immunity;Immunocompromised Host;Immunologic Techniques;Immunologics;improved outcome;In Vitro;in vivo;Individual;Inductively Coupled Plasma Mass Spectrometry;Infection;Infection Control;Innate Immune Response;interest;Interferon Type II;Interleukin-1;Knowledge;Limb structure;Lipopolysaccharides;Macrophage;Mass Spectrum Analysis;Mediating;Mediator;member;Memory;Metabolic;Metabolism;Metallothionein;Metals;microbial;Mississippi;Molecular;Molecular Sieve Chromatography;MT3 gene;Mus;Mycoses;Natural Immunity;Nature;Needs Assessment;Ohio;Oxidative Phosphorylation;pathogenic fungus;Patients;Phagocytes;Phenotype;Plasma;Process;programs;Property;Quantitative Reverse Transcriptase PCR;Reaction;Regulation;Research;Resistance;Resolution;respiratory;response;Reverse Transcriptase Polymerase Chain Reaction;Role;Shapes;Signal Transduction;Stimulus;T-Lymphocyte;Time;TNF gene;tool;Training;training data;Yeasts;Zinc;Zinc deficiency;zinc thionein;zinc-binding protein

PROJECT_TITLE: Metallothionein-Zinc Axis and Macrophage Memory to Fungi

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences;Pediatric

ORG_CITY: Charlestown

ORG_NAME: MGH INSTITUTE OF HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE The project proposes to examine functional and structural brain correlates of reading among children obligatorily relying on a single hemisphere following hemispherectomy surgery. This research has the potential to (1) offer a novel perspective on brain plasticity by focusing on reading acquisition using solely a left or right hemisphere; (2) improve our understanding of reading outcomes for students post-hemispherectomy; (3) relate individual differences in reading outcomes to brain structure and function; (4) add to the limited research on acquired reading difficulty during childhood; and (5) update knowledge for medical and education-based stakeholders. Our discovery of neurocognitive correlates of reading in isolated left or right hemispheres will offer a novel consideration of plasticity with insights to improve our understanding of reading difficulties as well as bring attention to proactive and preventative measures in support of children with reading difficulties.

PI_NAMEs: CHRISTODOULOU, JOANNA  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Acquired Dyslexia;Age;Anisotropy;Attention;Behavior assessment;Bilateral;Biological Markers;Boston;Brain;brain based;brain behavior;Brain region;Cerebral Dominance;Child;Child Support;Childhood;Clinical;cognitive skill;Communities;Complex;Data;Data Set;Development;Developmental Disabilities;Developmental reading disorder;Diffusion Magnetic Resonance Imaging;Dyslexia;early childhood;Early Intervention;Education;Ethics;experience;Freedom;Functional Magnetic Resonance Imaging;Goals;Hemispherectomy;Homologous Gene;improved;indexing;Individual Differences;Inferior;Injury;insight;Intervention;Investigation;Knowledge;Language;Learning Disabilities;Left;Linguistics;Measures;Medical;Mission;National Institute of Child Health and Human Development;National Institute of Neurological Disorders and Stroke;Neurocognitive;neuroimaging;Neuronal Plasticity;neurosurgery;Neurosurgical Procedures;novel;Operative Surgical Procedures;Oral;Outcome;Participant;peer;Performance;Pharmaceutical Preparations;Play;preventive intervention;Preventive measure;Property;Reader;Reading;reading ability;reading comprehension;reading difficulties;Recommendation;recruit;Research;Resistance;Role;School-Age Population;Seizures;skills;Structure;Students;symposium;System;theories;Time;United States National Institutes of Health;Update;white matter

PROJECT_TITLE: Plasticity of the reading brain: Insights from isolated left and right hemispheres

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Biobehavioral and Behavioral Sciences Study Section[CHHD-H]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Prevention;Vector-Borne Diseases

ORG_CITY: BLACKSBURG

ORG_DEPT: ZOOLOGY

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

PHR: PROJECT NARRATIVE Mosquito-borne La Crosse virus (LACV) is the leading arboviral cause of pediatric encephalitis in the United States (US), historically circulating in Appalachia and the Midwest. However, a novel genetic lineage (III) has been detected in the Northeastern US in multiple mosquito species, with clinical cases potentially occurring in this new region. Given the unknown public health risk associated with this lineage, this preliminary study will investigate horizontal and vertical transmission efficacies in both native and invasive mosquito species from the new (Northeastern) and traditional (Appalachia and the Midwest) regions, contrasting virus strains from all three LACV lineages.

PI_NAMEs: EASTWOOD, GILLIAN  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Address;Aedes;Affect;Age;anthropogenesis;Anti-viral Agents;Appalachian Region;Arbovirus Encephalitis;Arboviruses;Arthropods;Attenuated;Awareness;Bite;burden of illness;Characteristics;Child;Childhood;Circulation;Climate;Clinical;clinical diagnosis;Cognitive;Competence;Connecticut;cost;Culicidae;Data;Detection;Disease;Disease Vectors;Ecology;Economic Burden;economic impact;emerging virus;Encephalitis;enzootic;Epidemiology;epidemiology study;Evolution;exposed human population;Exposure to;Foundations;Future;Genetic;Geographic Locations;Geography;Goals;Growth;Health;Horizontal Disease Transmission;Human;human disease;Immunologics;improved;In Vitro;in vivo;Incidence;Infection;innovation;Intervention;Investigation;Kinetics;La Crosse virus;Licensing;long-term sequelae;Low Prevalence;Medical;Midwestern United States;Modeling;Molecular;Morphology;mosquito-borne;Mus;neurobehavioral;Neurologic;New England;North America;novel;Paralysed;pathogen;Pathogenesis;Patients;Phenotype;Physicians;Pilot Projects;Population;Positioning Attribute;Predisposition;Prevalence;Prevention strategy;Public Health;Recurrence;Reporting;Research;Resources;Risk;Risk Reduction;Seizures;Study models;Survivors;System;Therapeutic;therapeutic development;transmission process;United States;Urbanization;Vaccines;Variant;vector;vector competence;vector mosquito;Vertical Transmission;viral transmission;Virginia;Virulence;Virus;Virus Diseases

PROJECT_TITLE: Vector-virus determinants of the public health risk of La Crosse virus in the Northeastern USA

STUDY_SECTION: TVZ

STUDY_SECTION_NAME: Transmission of Vector-Borne and Zoonotic Diseases Study Section [TVZ]


NIH_SPENDING_CATS: Endocrine Disruptors;Genetics;Health Effects of Indoor Air Pollution;Human Genome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period

ORG_CITY: CLEMSON

ORG_DEPT: BIOLOGY

ORG_NAME: CLEMSON UNIVERSITY

PHR: The proposed research investigates the mechanisms of developmental toxicity of TBBPA- a high production volume flame retardant- and how it interferes with histone modification that are operant during zygotic genome activation. Through multiome assessments of genome-wide acetylation marks, chromatin accessibility and nascent transcription, we will uncover how TBBPA inhibits zygotic genome activation that results in developmental defects. The practical impact of this work is to gain a better understanding of gene products and their regulatory regions that modify zygotic transcription and can be further used in mechanistic or epidemiological studies to evaluate adverse developmental outcomes and disease mechanisms. Project Narrative

PI_NAMEs: DASGUPTA, SUBHAM  (contact)

PROJECT_TERMS: Acetylation;Adult;adverse outcome;Affect;Affinity;Architecture;ATAC-seq;Automobile Driving;Binding;Biological;Biological Assay;Biological Models;Biology;biomarker identification;blastocyst;Car Seats;Catalytic Domain;Cells;chemical group;Chemicals;Chemiluminescence assay;Chemistry;Child;ChIP-seq;Chromatin;chromatin modification;chromatin remodeling;Chronic;Commerce;Data;Defect;Development;Developmental Delay Disorders;Developmental Process;Developmental Toxicant;developmental toxicity;Disease;DNA;Docking;E1A-associated p300 protein;early life exposure;Electronics;Embryo;Embryonic Development;Environment;EP300 gene;Epidemiology;epidemiology study;Epigenetic Process;epigenetic regulation;Evaluation;Exposure to;Fertilization;Flame Retardants;Furniture;Future;Gastrula;Gene Expression;gene product;gene regulatory network;Genes;Genetic;Genetic Transcription;Genome;genome-wide;Goals;Grant;Health;Histone Acetylation;histone modification;Histones;Human;in silico;indoor dust;innovation;Knowledge;Label;Messenger RNA;Metabolic;Methylation;MicroRNAs;Modeling;Modification;Molecular;mortality;mRNA sequencing;Multiomic Data;multiple omics;Nature;next generation sequencing;novel;Nucleic Acid Regulatory Sequences;Nucleosomes;Ontology;Organism;Organogenesis;Outcome;Pathway Analysis;Pathway interactions;Pattern;Phase;Phenotype;Plasma;polyurethane foam;Population Study;prenatal exposure;Process;Production;promoter;Proteins;Research;Risk;Risk Assessment;RNA;Role;Sampling;Serum;Signal Transduction;small molecule;System;Technology;Testing;tetrabromobisphenol A;Therapeutic;Toddler;Toxic effect;Toxic Environmental Substances;Transcription Initiation;transcriptome sequencing;Umbilical Cord Blood;Western Blotting;Work;Xenobiotics;Zebrafish

PROJECT_TITLE: Uncovering the Role of Histone Acetylation in Tetrabromobisphenol A-induced Developmental Toxicity during Zygotic Genome Activation

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pain Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

PHR: Chronic pain is a major population health issue affecting more than 100 million Americans and variations in chronic pain experiences have been widely documented, including differences in pain burden and likelihood of undertreatment. Evidence regarding chronic pain experiences of Asian Americans is limited, as are resources and evidence-based programs for this group. Our exploratory, developmental study will provide evidence of feasibility and acceptability of a tailored psychosocial education intervention to reduce pain catastrophizing and improve pain outcomes for Asian Americans.

PI_NAMEs: KIM, HEE JUN  (contact)

PROGRAM_OFFICER_NAME: TYUS, NADRA

PROJECT_TERMS: acceptability and feasibility;Achievement;addiction;Adult;Affect;American;Analgesics;Area;Asian;Asian Americans;Asian population;Attitude;Baltimore;Behavior;Belief;chronic pain;clinical pain;Cognitive Therapy;Communities;community advisory board;community based participatory research;community engagement;community organizations;community partners;Complex;culturally appropriate intervention;design;Development;Diagnosis;Dimensions;disability;Disparity;disparity reduction;Education;Educational Intervention;Effectiveness;efficacy trial;Emotions;Environment;Ethnic Origin;Ethnic Population;Evidence based practice;Evidence based program;Exhibits;experience;Family;Focus Groups;Fright;Goals;Group Interviews;Health;health inequalities;Health Personnel;Health Priorities;healthcare burden;high risk;Immigrant;improved;Individual;Intervention;Interview;Knowledge;Korea;Korean American;Koreans;Learning;Limited English Proficiency;Linguistics;Literature;Lived experience;marginalization;Medical Assistance;meetings;Mental Depression;Methods;metropolitan;Minority Groups;Not Hispanic or Latino;Nurses;Opioid;Outcome;Pain;pain behavior;pain catastrophizing;Pain intensity;Pain interference;Pain management;pain outcome;pain reduction;Pain Research;pain sensitivity;Participant;patient engagement;Persons;Population;population health;post intervention;Pre-Post Tests;programs;psychoeducation;psychoeducational intervention;psychological distress;psychosocial;racial minority population;racial population;rapid growth;recruit;Reporting;Research;Research Priority;Resources;retention rate;Severities;side effect;social;Social isolation;societal costs;sociocultural determinant;South Korea;Structure;Surveys;Testing;therapy design;Thinking;Time;Underrepresented Minority;Underrepresented Populations;underserved minority;Washington;Work

PROJECT_TITLE: Developing a Tailored Psychosocial Education Intervention for Chronic Pain Management for Asian Americans in the Community

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Disability Research;Genetics;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine;Prevention;Rare Diseases

ORG_NAME: HUGO W. MOSER RES INST KENNEDY KRIEGER

PHR: PROJECT NARRATIVE The proposed research aims to identify novel monitoring and prognostic biomarkers in a devastating neurological disorder. It is relevant to public health because if successful it will enable implementation of clinical trials and relevant information that can be used for prognosis in clinical setting. The proposed research is relevant to the part of the NINDS mission that pertains to acquiring and using fundamental new knowledge of the nervous system to decrease the burden of neurological disease.

PI_NAMEs: FATEMI, S. ALI  (contact);SINGH, JASPREET

PROGRAM_OFFICER_NAME: TAYLOR-BURDS, CAROL C

PROJECT_TERMS: Adrenoleukodystrophy;Adrenomyeloneuropathy;Adult;Affect;Age;Alzheimer's Disease;Area;axonopathy;Bayesian neural network;Biological Markers;biomarker signature;Birth;Bladder;Blood;Classification;CLIA certified;Clinical;Clinical assessments;clinical outcome assessment;clinical outcome measures;clinical predictors;clinical trial implementation;Clinical Trials;clinically relevant;cohort;Complement;Computers;Confidence Intervals;Corticospinal Tracts;Data;disability;Disease;disease prognostic;Disease Progression;dorsal column;Engineering;Enrollment;Female;Gait;Genes;Genetic Diseases;Goals;Grant;Hereditary Disease;Impairment;Incidence;Individual;interdisciplinary approach;Intestines;Knowledge;Label;Laboratories;leukodystrophy;Logistic Regressions;Machine Learning;male;Measures;metabolome;metabolomics;MicroRNAs;miRNA expression profiling;Mission;Modeling;Molecular;Monitor;multidimensional data;multiple omics;Mutation;National Institute of Neurological Disorders and Stroke;Nature;Neonatal Screening;Nervous System;Nervous System Disorder;Neuroglia;Neurologic;Neurologic Symptoms;Neurological disability;novel;Outcome Measure;Outcomes Research;Parkinson Disease;Patients;Peripheral Nerves;Persons;Phase;Plasma;Posture;predictive tools;Probability;Prognosis;prognostic;Prognostic Marker;prognostic tool;prognostic value;prognostication;prospective;Prospective cohort;Public Health;Publications;Research;research and development;Research Personnel;Sampling;Sensory Ataxias;Series;Severity of illness;sex;Spastic Paraparesis;Techniques;Testing;Therapeutic;tool;Training;Validation;Variant;Very Long Chain Fatty Acid;Walking;Wheelchairs;women subjects

PROJECT_TITLE: Discovery and validation of multi-omic plasma biomarkers for Adrenomyeloneuropathy

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders B Study Section[NSD-B]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Atherosclerosis;Autoimmune Disease;Cardiovascular;Heart Disease;Rheumatoid Arthritis

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: NARRATIVE Chronic inflammation is a major contributor to the premature mortality due to cardiovascular disease observed in patients with rheumatoid arthritis. This project seeks to leverage murine models to explore the hypothesis that inflammatory arthritis trains innate immune cells leading to increased inflammatory effector function, which may provide a novel mechanism linking inflammatory arthritis and cardiovascular disease. This application seeks pilot funding for a K01 awardee (Dr. MacLauchlan, PI) in her fourth year of funding to pursue this hypothesis and outlines a plan to transition these findings into future R01 funding.

PI_NAMEs: MACLAUCHLAN, SUSAN C. (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Acceleration;Adaptive Immune System;Agonist;Aorta;aortic arch;Arthritis;Arthritogenic;Atherosclerosis;Autoimmune;Autoimmune Diseases;B-Lymphocytes;Behavior;beta-Glucans;Bone Marrow;Cardiovascular Diseases;cardiovascular disorder risk;career;Cells;Cessation of life;Chronic;chronic autoimmune disease;chronic inflammatory disease;cost;cytokine;Data;dectin 1;Detection;Development;Dose;Exhibits;Exposure to;feeding;Foam Cells;Funding;Future;Goals;Hematopoietic stem cells;IL6 gene;Immune;Immune response;Immunity;Immunologic Memory;improved;Incidence;Infection;Infiltration;Inflammation;Inflammatory;Inflammatory Arthritis;Innate Immune System;Interleukin-1 beta;Investigation;joint inflammation;Joints;Left;Link;Lymphocyte;Macrophage;Measures;Memory;Modeling;Molecular;monocyte;mouse model;Mus;Myeloid Cells;neutrophil;novel;pathogen;Pathogenesis;Patients;Pattern;Persons;Phenotype;Pilot Projects;premature;Premature Mortality;Process;Production;Reaction;receptor;Research;Research Personnel;Resolution;response;Rheumatoid Arthritis;Risk;Risk Factors;Role;Serum;Signal Transduction;single-cell RNA sequencing;Sorting;Sterility;Stimulus;Synovial Membrane;T-Lymphocyte;Testing;TLR1 gene;TNF gene;Training;transcriptome sequencing;Vaccination;vascular inflammation;western diet

PROJECT_TITLE: Trained immunity as a link between Inflammatory Arthritis and development of Cardiovascular Disease

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Aging;Digestive Diseases;Neurosciences;Nutrition;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Public health relevance In addition to its nutrient-absorption functions, the gut epithelium is the site in which neural, immune, microbial, and dietary factors interact. Through these interactions, the gut could regulate whole-body physiology ranging from metabolism, immunity to cognition. One important but unsolved problem is how mechanical forces naturally present in the gut could regulate the physiological functions of the gut and other tissues. In this collaborative project, we leverage the power of the model organism Drosophila and combine it with the state-of-the-art metabolomic approaches to explore the novel role of gut mechanosensing in metabolism and aging.

PI_NAMEs: HE, YE ;XIANG, YANG  (contact)

PROGRAM_OFFICER_NAME: FLORES, ROBERTO L

PROJECT_TERMS: absorption;Address;Adenosine;Adult;aged;Aging;aging process;aging related;Alzheimer's Disease;Biological Models;Brain;Cell Aging;cell behavior;cell type;Cells;Cognition;cohort;Defect;Detection;Dietary Factors;Disease;Drosophila genus;Dysplasia;Enterocytes;Enteroendocrine Cell;Epithelium;Exhibits;Exposure to;fly;Food;gastrointestinal epithelium;gastrointestinal function;Gastrointestinal tract structure;Generations;Genetic;Genetic Models;Goals;Growth;Health;Image;Immune;Immunity;In Situ;innovation;insight;interest;Intestines;Investigation;Ion Channel;Label;Link;lipid metabolism;Lipids;liquid chromatography mass spectrometry;Lysophosphatidylcholines;Malignant Neoplasms;Mammals;mechanical force;mechanotransduction;Mediating;Metabolic;Metabolic dysfunction;Metabolism;metabolomics;Methods;microbial;Midgut;model organism;Modeling;Molecular;mutant;Mutation;neural;Neurodegenerative Disorders;Neuropeptides;novel;nutrient absorption;Peristalsis;Physiological;Physiological Processes;Physiology;Pilot Projects;public health relevance;Publications;Publishing;Purinergic P1 Receptors;Purines;Purinoceptor;receptor;Resolution;response;Role;sensor;shear stress;Signal Transduction;Signaling Molecule;Site;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;stem cell proliferation;stem cells;Stretching;synergism;System;Tachykinin;Testing;Time;Tissues;tool;Work

PROJECT_TITLE: Metabolomic interrogation of gut mechanosensing in Drosophila

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]