NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Neurosciences;Pediatric;Substance Misuse;Underage Drinking

ORG_DEPT: NEUROSCIENCES

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: 8. PROJECT NARRATIVE The data collected from the proposed studies will increase our understanding of how adolescent alcohol abuse alters the function of the adult brain including decision making. The findings will also provide a better understanding of the brain changes associated with the long-term effects of adolescent alcohol abuse that will help at-risk populations.

PI_NAMEs: CHANDLER, L JUDSON (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Adolescence;Adolescent;adolescent alcohol abuse;adolescent alcohol effect;adolescent alcohol exposure;Adult;age group;Alcohol abuse;Alcohol consumption;alcohol involvement;Alcoholic Intoxication;Alcohols;Animal Model;Astrocytes;ATAC-seq;Axon;Behavior;Behavior Control;Behavioral;behavioral impairment;Brain;cell type;Cells;Characteristics;Clustered Regularly Interspaced Short Palindromic Repeats;Cognition;Cognitive;cognitive ability;cognitive control;Cognitive deficits;cognitive function;Collaborations;confocal imaging;Consumption;Cre driver;critical period;Data;Decision Making;Dendritic Spines;design;Development;Developmental Delay Disorders;Disease;DNA;DNA Methylation;DNA Methylation Inhibition;Dopamine;Dopamine D1 Receptor;dopamine system;dopaminergic neuron;Electrophysiology (science);Epigenetic Process;Ethanol;executive function;Exhibits;experimental study;flexibility;Gene Expression;Genes;genetic manipulation;Growth;Hypermethylation;Impaired cognition;In Situ;in vivo;inhibitor;innovation;Interneurons;Intoxication;Label;Legal;Link;Long-Term Effects;Medial;Mediating;Methodology;Methylation;Microglia;Morphology;multidisciplinary;Mus;nerve supply;neural circuit;neurodevelopment;Neuroglia;Neuromodulator;Neurons;neurotransmission;Neurotransmitters;novel;novel therapeutic intervention;Nucleus Accumbens;Parvalbumins;patch clamp;Pattern;Play;Population;Populations at Risk;Prefrontal Cortex;Presynaptic Terminals;Procedures;Process;promoter;Promoter Regions;Public Health;Pyramidal Cells;Rattus;receptor expression;Research;Research Personnel;response;Role;Safety;Schizophrenia;Short-Term Memory;Signal Pathway;Signal Transduction;Slice;Synapses;Technology;Testing;Three-dimensional analysis;Time;transition to adulthood;ultra high resolution;underage drinking;Viral Vector

PROJECT_TITLE: 6/8 NADIA U01 Adolescent Alcohol and Prefrontal Cortical Function in the Adult


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: OXFORD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: CHEMISTRY

ORG_FIPS: US

ORG_NAME: MIAMI UNIVERSITY OXFORD

ORG_STATE: OH

PHR: PROJECT NARRATIVE. The ability of cancers to develop resistance to chemotherapy is a longstanding problem that causes significant mortality. Our research program develops a new class of drug that hijacks the metabolism of drug-resistant cancer cells, causing the body's own immune system to recognize and clear the cancer. We envision that this technique could be developed into a new type of therapy that has both fewer side-effects than conventional chemotherapy and enhanced efficacy relative to established immunotherapies.

PI_NAMEs: MANCINI, ROCK  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: ABCB1 gene;acquired drug resistance;Active Biological Transport;Address;Agreement;Allografting;anti-cancer;anti-cancer therapeutic;Antineoplastic Agents;Area;ATP-binding cassette transport;Binding;Biodistribution;Biological Models;cancer cell;Cancer cell line;cancer drug resistance;cancer immunotherapy;Cancer Patient;cancer therapy;cancer type;Carrier Proteins;Cell Survival;Cells;chemotherapy;Coculture Techniques;Cohort Studies;conventional therapy;Coupling;cytotoxic;Data;Development;Diffusion;Disseminated Malignant Neoplasm;Drug Efflux;drug metabolism;Drug resistance;Drug Transport;Enzyme Tests;Enzymes;Exhibits;Extracellular Space;Goals;Immune;immune modulating agents;Immune response;Immune system;Immunocompetent;immunogenicity;Immunomodulators;Immunotherapeutic agent;Immunotherapy;In Vitro;in vivo;in vivo Model;inhibitor;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Metabolic;Metabolic Pathway;Metabolism;Methods;Modality;mortality;mouse model;Multi-Drug Resistance;multidrug resistant cancer;Mus;nanomedicine;novel drug class;novel therapeutics;Outcome;overexpression;Pharmaceutical Preparations;Phenotype;Predisposition;Process;Prodrugs;programs;Progression-Free Survivals;prostate cancer model;rational design;refractory cancer;Reporting;Research;Resistance development;RNA Interference;side effect;small molecule;Specificity;synthetic enzyme;Techniques;Testing;Therapeutic;Toxic effect;Treatment Efficacy;Tumor Escape;tumor metabolism;tumor microenvironment;Tumor Volume;tumorigenesis;Work

PROJECT_TITLE: Exploiting Cancer Metabolism and Drug Efflux with Bystander-Assisted Immunotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-Y(55)R]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Osteoporosis;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Using real-world observational data, we propose to emulate three randomized trials comparing the benefits and harms of osteoporosis drug regimens in adults at a wide range of risk for fragility fractures. Furthermore, we will produce a ready-to-use shared decision-making tool to translate the knowledge produced into practice. 1

PI_NAMEs: BRITO CAMPANA, JUAN P (contact);MCCOY, ROZALINA GRUBINA

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Address;Adherence;Admission activity;Adult;Adverse effects;Advisory Committees;aging population;American;Anabolic Agents;beneficiary;Biometry;bisphosphonate;Black Populations;bone;Bone necrosis;Caring;Cessation of life;comparative effectiveness;comparative safety;compare effectiveness;Complement;cost;Data;Data Set;data warehouse;Debility;Deductibles;disability;economic impact;Effectiveness;Electronic Health Record;Endocrinology;Ensure;Equity;Evaluation;evidence base;Exclusion;experience;Fee-for-Service Plans;Femoral Fractures;field study;Fracture;fracture risk;fragility fracture;Future;Gender;Geography;Glucocorticoids;Goals;Health;health plan;Health Services Research;Health system;Heterogeneity;high risk;high risk population;Hip Fractures;Hispanic Populations;Holidays;Hospitalization;Human;human old age (65+);Impairment;improved;insurance plan;Interruption;Jaw;Knowledge;Link;Medical;Medical Care Costs;Medicare;men;Methods;Minerals;Modality;mortality;multidisciplinary;Nursing Homes;Observational Study;Office Visits;Osteoporosis;osteoporosis with pathological fracture;Outcome;Pain;Patient Care;patient oriented;Patient-Centered Care;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Population;premature;prevent;Prevention;primary care practice;primary outcome;Privatization;Quality of life;randomized trial;Randomized, Controlled Trials;Recommendation;Recording of previous events;Regimen;Research;Risk;Risk Reduction;Safety;Sampling;secondary outcome;Series;shared decision making;side effect;Societies;Spinal Fractures;stem;Steroids;Subgroup;therapy duration;Time;tool;Translating;Translational Research;Translations;treatment effect;treatment strategy;trial comparing;Underrepresented Populations;Update;uptake;Woman;Work;wrist fracture

PROJECT_TITLE: Comparative Effectiveness and Safety of Osteoporosis Drug Therapies


ADMINISTERING_IC: HL

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Project Narrative This proposed community-based participatory research (CBPR) mixed methods (MMR) project will address important research gaps by exploring the relationship between food swamps (i.e., areas where unhealthy food retailers outnumber healthier alternatives), parents' perceived food and beverage access, parents' food and beverage shopping habits, and dietary preferences and food and beverage intake among racial/ethnic minority preschool-aged children in 6 socioeconomically diverse Hartford neighborhoods. This formative research to inform intervention development will also explore parents' level of support for policy, systems, and environmental strategies to reduce racial/ethnic dietary disparities among young children. Through this innovative research project and additional training in CBPR, GIS, Mixed Methods, Intervention Development, the early-stage investigator will be prepared for an independent health equity research program with the ultimate goal of alleviating diet-related health inequities among young children.

PI_NAMEs: COOKSEY STOWERS, KRISTEN  (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Adult;Affect;Age;Area;Behavior;Behavior Control;Beverages;Black race;Censuses;Child;Child Health;Communities;community advisory board;community based participatory research;community setting;Data;Data Set;design;Development;Diet;dietary;Dietary intake;Disparity;early childhood;Eating;Eating Behavior;Environment;environmental intervention;Environmental Risk Factor;Equity;ethnic disparity;ethnic diversity;ethnic minority;Ethnic Origin;evidence base;Exposure to;fast food;Fatty acid glycerol esters;Feedback;Focus Groups;Food;Food Access;food environment;Food Preferences;fruits and vegetables;Future;Goals;Grant;Habits;Health;health disparity;Health equity research;Health Food;health inequalities;Home;improved;Inequity;innovation;Intake;Intervention;intervention mapping;Intervention Trial;Interview;Joints;Knowledge;Latino;Link;Maps;Measures;member;Mentored Research Scientist Development Award;Mentorship;method development;Methods;minority children;Neighborhoods;novel;Nursery Schools;nutrition;Obesity;obesity in children;obesity treatment;Outcome;Parents;Perception;Phase;Physical activity;Play;Policies;policy implication;preference;Prevalence;programs;Race;racial disparity;racial minority;Research;Research Personnel;Research Project Grants;Role;School-Age Population;Series;social factors;socioeconomics;sugar;Surveys;System;Techniques;Testing;therapy development;Time;Training;United States;United States National Institutes of Health;Water;Work;Writing

PROJECT_TITLE: Are Food Swamps Linked to Disparities in Ethnically Diverse Parents' Food Shopping Behaviors & Young Children's Diets?: Implications for Policy & Environmental Interventions


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: SOLNA

ORG_COUNTRY: SWEDEN

ORG_FIPS: SW

ORG_NAME: KAROLINSKA INSTITUTE

PHR: Project Narrative  Due to severe damage of the nervous control of posture and balance, spinal cord injured patients are bound to a wheelchair and their rehabilitation constitutes both clinical and social problems. The proposed project will provide unique information about changes in supraspinal postural networks underlying distortion and recovery of postural functions after incomplete spinal cord injuries (that are most common cases in spinal cord injured patients). The present project will contribute to development of rehabilitation strategies aimed at restoration/improvement of postural functions in spinal cord injured patients, as well as in patients with postural deficits of other etiology (e.g. caused by stroke, Parkinson’s disease, etc.).

PI_NAMEs: DELIAGINA, TATIANA G (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Acute;Address;Affect;Animal Model;Animals;Behavior;Binding;Brain;Brain Stem;Cell Nucleus;Clinical;Clinical Data;clinically relevant;comparison control;Control Animal;Corticospinal Tracts;Data;design;designer receptors exclusively activated by designer drugs;Development;Dorsal;dorsal visual stream;Equilibrium;Etiology;Functional disorder;Genetic;genetic manipulation;Goals;Grant;improved;Individual;kinematics;Lateral;Limb structure;Lumbar spinal cord structure;Modification;motor deficit;motor disorder;motor function recovery;Muscle Tonus;Musculoskeletal Equilibrium;Neurons;novel;operation;Oryctolagus cuniculus;Parkinson Disease;Pathway interactions;Patients;Pattern;Performance;Persons;Play;Population;Postural response;Posture;preservation;prevent;Recovery;Recovery of Function;Reflex action;rehabilitation strategy;Rehabilitation therapy;restoration;Role;Side;Signal Transduction;Social Problems;spasticity;Spinal;Spinal Cord;Spinal cord damage;Spinal cord injury;Spinal cord injury patients;spinal pathway;spinal shock;Stroke;System;Techniques;Testing;transmission blocking;transmission process;United States National Institutes of Health;Wheelchairs;Work

PROJECT_TITLE: Restoration of Postural Control After Spinal Cord Injury

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Lung;Patient Safety;Prevention;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: RELEVANCE Nearly one million patients per year in the United States require invasive mechanical ventilation for acute respiratory failure, a life-threatening condition. Many of those who recover to the point that their breathing tube is removed would benefit from mechanical ventilation delivered through a face mask or oxygen delivered through a high-flow nasal cannula, but these practices are currently underutilized. This clinical trial will compare innovative strategies designed to promote the use of these evidence-based practices.

PI_NAMEs: GIRARD, TIMOTHY D (contact)

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: acceptability and feasibility;active control;Acute respiratory failure;Address;Adoption;Adult;Area;Breathing;Cannulas;Caring;Cessation of life;Clinical;clinical center;Clinical Protocols;Clinical Trials;compare effectiveness;contextual factors;Critical Care;Data;design;E-learning;Education;Educational Intervention;Effectiveness;effectiveness testing;effectiveness/implementation trial;Eligibility Determination;Evidence based practice;face mask;Funding;Grant;high risk;Hospital Mortality;Hospitals;implementation barriers;implementation strategy;implementation tool;improved outcome;innovation;Inpatients;insight;intervention refinement;Interview;Intubation;Learning;Life;Link;Mechanical ventilation;Medical;member;Memory;Morbidity - disease rate;mortality;Nature;Nose;novel;Outcome;Oxygen;patient oriented;Patient risk;Patients;Persons;pilot test;Population;prevent;Preventive;Process;Protocols documentation;Provider;Qualitative Evaluations;Randomized;Randomized, Controlled Trials;Recurrence;Research;respiratory;Respiratory Failure;Respiratory Therapy;Risk;Role;Series;Surveys;theories;therapy design;Tube;United States;ventilation;Work

PROJECT_TITLE: The Maximizing Extubation outcomes Through Educational and Organizational Research (METEOR) Trial


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Narrative – Overall: Senescent Cell Evaluation in Normal Tissues Senescence is a critical part of aging but remains poorly understood. Our proposal will apply new single cell technologies in different organs across the age spectrum to identify and understand how human senescence happens, with a goal of designing unbiased, data-based, targeted therapies for a range of aging-related diseases.

PI_NAMEs: KRAFT, MONICA ;LEE, PATTY J;NIXON, ANDREW B. (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Address;Age;age related;Aging;aging related disease;Agreement;Area;Atlases;biobank;Biochemical;Bioinformatics;Biological;biological adaptation to stress;Blood;Cell Aging;Cell model;Cells;Cellular Structures;Clinical;Clinical Trials;Collaborations;Colon;Communication;Computer software;Consultations;Critical Care;Data;Data Analyses;Data Collection;data integration;data sharing;deep learning algorithm;demographics;design;Development;dimensional analysis;disability;Evaluation;Faculty;Future;geroprotector;Goals;healthy aging;Heart;Heart Transplantation;Heterogeneity;Human;human tissue;Immune;Immunologics;Immunophenotyping;Improve Access;Institution;interoperability;Investigation;Knowledge;Leadership;Lung;Lung Transplantation;Maps;medical schools;Methods;Mission;Molecular;multimodality;Muscle;normal aging;Normal Cell;Normal tissue morphology;Organ;Organoids;Peripheral Blood Mononuclear Cell;Phase;Phenotype;preservation;Problem Solving;Process;prospective;Protocols documentation;repaired;Research;resilience;Resolution;Scientist;senescence;senescent cell;single cell technology;skills;Skin;Specimen;targeted treatment;Testing;Therapeutic;tissue mapping;Tissues;Translational Research;Transplantation Surgery;United States National Institutes of Health;Universities

PROJECT_TITLE: The Duke Senescent Cell Evaluations in Normal Tissues (SCENT) Mapping Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(70)R]


NIH_SPENDING_CATS: Aging

PHR: Narrative – Administrative Core: Senescent Cell Evaluation in Normal Tissues Senescence is a critical part of aging but remains poorly understood. This Administrative Core that will lead and coordinate the efforts of 3 other Cores to apply technologies in different organs across the age spectrum to identify and understand how human senescence happens, with a goal of designing unbiased, data-based, targeted therapies for a range of aging-related diseases.

PI_NAMEs: LEE, PATTY J (contact)

PROJECT_TERMS: Accounting;Advisory Committees;Age;age related;Aging;aging mechanism;aging related disease;Agreement;Amendment;Atlases;Award;biobank;Biological;Biological Assay;Biometry;Blood Vessels;cell type;Cells;Cellular biology;Collaborations;Common Data Element;Communication;Communities;Cooperative Human Tissue Network;Critical Care;Data;Data Analyses;data analysis pipeline;Data Coordinating Center;data submission;data visualization;design;Development;Ensure;Evaluation;experience;Faculty;Funding;Generations;Glass;Goals;Human;Human Resources;human subject;Hypersensitivity;Immune;Infrastructure;Institution;Institutional Review Boards;International;interoperability;Laboratories;Lead;Leadership;Lung;Maps;Measures;Medical center;medical schools;Medicine;meetings;member;metadata standards;Methods;Monitor;mouse model;multidisciplinary;multiple omics;new technology;Normal tissue morphology;novel;novel strategies;Nursing Faculty;Office of Administrative Management;Ontology;operation;Organ;Pathology;Physicians;Pilot Projects;Policies;Procedures;Productivity;professor;Progress Reports;Protocols documentation;Publications;Pulmonary Emphysema;recruit;Regulation;Reporting;Research;research faculty;Research Personnel;Resources;Science;Scientist;senescence;senescent cell;Site;Standardization;targeted treatment;Technology;technology development;Time;tissue mapping;Tissues;Training;U-Series Cooperative Agreements;United States National Institutes of Health;Universities;Update;virtual;Visualization software;Work

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D]


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Lung;Organ Transplantation;Pediatric;Social Determinants of Health;Transplantation

PI_NAMEs: GLASS, CAROLYN  (contact)

PROJECT_TERMS: Academic Medical Centers;Accreditation;Age;age group;Ambulatory Care Facilities;Atlases;Autopsy;biobank;Biological;Biological Assay;Biological Markers;Biopsy;Blood specimen;Board Certification;Body System;Bronchoscopy;Cardiac Surgery procedures;Cell Aging;Cell Proliferation;Childhood;Clinic;Clinical;Clinical Data;Clinical Trials;clinically relevant;cohort;Collaborations;Collection;Colon;Communities;Consent;Consent Forms;Country;Coupled;data management;data repository;data sharing;demographics;Diagnosis;Elderly;Endoscopy;Enrollment;Ensure;environmental stressor;Epidemiology;Evaluation;Exposure to;Faculty;fetal;Fresh Tissue;Funding;Gastroenterology;gender diversity;Goals;Health;Heart;Heart Transplantation;Heterogeneity;Home;Hospitals;human tissue;Individual;Infant;Informatics;Institution;interest;International;Intervention;Investigation;Laboratories;Language;life span;Liquid substance;Lung;Lung Transplantation;Maps;Measures;middle age;Modification;Molecular;Muscle;Normal tissue morphology;Operative Surgical Procedures;Organ;Organ Donor;Organ Transplantation;Participant;participant enrollment;Pathologic;Pathologist;Pathology;Perinatal;peripheral blood;Phase;Population;postmitotic;Practice Guidelines;Predisposition;Procedures;Process;programs;prospective;Protocols documentation;Pulmonology;quality assurance;Quality Control;Race;real time monitoring;recruit;Regulation;Research;Research Personnel;Research Support;Resource Sharing;saliva sample;Sampling;scale up;Schedule;Secure;senescence;senescent cell;Services;Skin;Socioeconomic Status;Somatic Mutation;Source;Specimen;standard of care;stem cells;stool sample;Swab;Tissue Banks;tissue mapping;Tissue Procurements;tissue resource;Tissues;Training;transplant centers;United States;Work

PROJECT_TITLE: Biospecimen Core


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: LONG BEACH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: CA

PHR: The collaborative MERIT proposal hypothesizes that hyperinflammatory profiles in Gulf War Veterans could be due to exposures to chemical and/or environmental stressor and multiple vaccinations experienced by Veterans during the Gulf War, which sensitizes the affected veterans to the development of Gulf War Veterans Illness. The present project led by Saurabh Chatterjee (Project 2) is designed in both rodent models and veterans’ cohort to test the hypothesis that chemical stressors, like insecticides and nerve gas antidotes routinely used during deployment, may induce gastrointestinal dysbiosis (gut microbiome changes) and metabolomic alterations via modulations of the gut inflammasome. These microbiome changes may lead to disruptions in barrier functions thus allowing continuous penetration of endotoxin/inflammatory mediators into the brain. These events may ultimately induce a sustained hyperinflammatory state while inflammasome blockers/probiotics may attenuate the above responses by blocking dysbiosis.

PI_NAMEs: CHATTERJEE, SAURABH  (contact)

PROJECT_TERMS: Affect;Animal Model;Antidotes;arm;Attenuated;attenuation;Autoantibodies;Autoimmune Diseases;Award;Biological Models;Biological Response Modifiers;Blood;Brain;Bromine;Butyrates;Cell Death;Chemical Exposure;Chemicals;Chemistry;Clinical;cohort;Collaborations;Complex;Coupled;cytokine;Data;design;Development;Diagnosis;Disease;dysbiosis;Endotoxemia;Endotoxins;environmental stressor;Etiology;Event;experience;Experimental Models;Exposure to;Fatigue;Female;fluorophosphate;Future;gastrointestinal;Generations;Genes;Genetic Polymorphism;Genetic Variation;glial activation;Goals;Gulf War;Gulf War veteran;gut dysbiosis;gut microbiome;HMGB1 gene;Human;Hydroxybutyrates;Immune;immune activation;Immune response;Immune system;Immunity;Immunologic Tests;Immunologics;Immunotherapeutic agent;Impaired cognition;Individual;Inflammasome;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;inhibitor;innovation;innovative technologies;Insecticides;insight;Interdisciplinary Study;interest;Interleukin-1 beta;Intestines;Isoprostanes;Joints;Knock-out;Knockout Mice;Leptin;Link;Lipid Peroxides;Mediating;Medical center;metabolomics;Metagenomics;Microbiology;microbiome;microbiome alteration;Molecular;Mood Disorders;mouse model;multidisciplinary;Mus;nerve gas;neural;neuroinflammation;Neurons;Neurosciences;novel;novel therapeutic intervention;Organ failure;Outcome Study;Oxidative Stress;Pain;Pathologic;Pathology;Pathway interactions;Pattern;Pattern recognition receptor;Penetration;Permethrin;Pesticides;Pharmacology;Phenotype;Plasma;Play;pre-clinical research;Predisposition;Probiotics;programs;Proteins;psychological stressor;Public Health Schools;pyridostigmine;Reaction;Receptor Activation;Receptor Cell;Research;Research Personnel;Research Project Grants;response;Rodent;Rodent Model;Role;Sampling;Science;Septic Toxemia;Small Intestines;Stimulus;Stress;stressor;Symptoms;Synaptic plasticity;synergism;Testing;Therapeutic Effect;Therapeutic Studies;tissue degeneration;Toxic Environmental Substances;Toxin;Translating;translational study;Uranium;Vaccination;Vaccines;Veterans;Veterans Health Administration;Vision;Women's study;Work

PROJECT_TITLE: CMA: Immune/Inflammatory Priming in Exacerbating Responses to GWVI Stressors: Implications for GWVI Treatments


FUNDING_MECHANISM: OTHERS

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Deep vein thrombosis (DVT), where blood clots (thrombi) develop in the deep veins of the body, is a common disease with an incidence of 1 case per 1000 persons that can cause significant morbidity and mortality. Despite standard medical treatment, primarily with anticoagulants, failure of clots to dissolve and blood flow and vein function to reestablish after DVT results in post-thrombotic syndrome (PTS), a chronic and disabling condition where signs and symptoms of DVT persist months to years after the initial diagnosis of DVT in up to 75% of patients. A better understanding of how clots dissolve during DVT resolution and the fibrotic processes affecting vein wall function may potentially allow us to develop alternative anti-inflammatory and anti-fibrotic therapies to treat DVT and prevent PTS. We will study a naturally occurring hormone called relaxin and its role in DVT resolution and PTS.

PI_NAMEs: NGUYEN, KHANH P. (contact)

PROJECT_TERMS: Academic Training;Acute;Affect;Anatomy;Anti-Inflammatory Agents;Anticoagulants;Anticoagulation;antifibrotic treatment;Antithrombin III;Area;Award;Basic Science;Biological Markers;Biology;biomechanical test;Biomechanics;Biometry;Blood coagulation;Blood flow;Blood Vessels;Cardiovascular Diseases;Cardiovascular system;career;Catheters;Chronic;Chronic disability;Clinical;Clinical Data;Clinical Research;Clinical Trials;clinically relevant;Coagulation Process;collaborative environment;Contrast Media;Creativeness;Data Analyses;Data Collection;data management;deep vein;Deep Vein Thrombosis;design;Development;Diagnosis;didactic education;Disabling condition;Disease;Double-Blind Method;elastography;Extracellular Matrix;Factor Xa;Failure;Family;feasibility testing;ferumoxytol;Fibrosis;Functional disorder;Goals;graduate school;Growth Factor;healing;Health;Healthcare Systems;Histologic;Hormones;Human;IL8RB gene;Image;Imaging Techniques;Immune;Immune response;Immune system;Immunology;Impairment;improved;in vivo;in vivo imaging;Incidence;Incidence Study;Inflammation;Inflammation Process;Inflammatory;Innate Immune System;Interleukin-8;K-Series Research Career Programs;Leadership;Leg;Lifelong disability;Link;Lower Extremity;Macrophage;Magnetic Resonance;Magnetic Resonance Imaging;Measures;Mediating;Medical;Mentors;Mentorship;microCT;Microscopy;Modeling;Modernization;Molecular;Molecular Biology;molecular imaging;monocyte;Morbidity - disease rate;mortality;mouse model;multidisciplinary;Mus;Natural Immunity;neovascularization;neutralizing monoclonal antibodies;neutrophil;novel;Oral;Oregon;Pathway interactions;Patient Care;patient oriented research;Patients;Peptide Receptor;Persons;Physicians;Plasma;postcapillary venule;Postphlebitic Syndrome;pre-clinical;prevent;Process;programs;prospective;Quality of life;radiological imaging;Randomized;Randomized, Controlled Trials;recruit;Recurrence;Reflux;Regulation;Relaxin;Reporting;Research Design;Residual state;Resolution;response;Role;Science;Scientist;secondary outcome;Serum;Severities;Signal Transduction;Signs and Symptoms;skills;Surgeon;Surveys;T-Lymphocyte;T2 weighted imaging;Testing;Therapeutic Agents;Thick;thrombolysis;Thrombosis;thrombotic;Thrombus;Tissues;TLR4 gene;TLR9 gene;Training;Transgenic Mice;Transgenic Model;Translational Research;ultrasound;Universities;Vascular Diseases;vascular injury;Veins;Venous;venule;Visualization;Warfarin

PROJECT_TITLE: Mechanisms of Deep Vein Thrombosis (DVT) and Vein Wall Fibrosis


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: CHAN, CLIBURN C (contact)

PROJECT_TERMS: Age;Architecture;Bioinformatics;Biological;Biological Assay;Biological Markers;biomarker signature;Cadaver;Catalogs;Cell Aging;cell type;Cells;Cellular Assay;Common Data Element;comparative;Computational Biology;Computer software;computerized data processing;Confounding Factors (Epidemiology);dashboard;Data;Data Analyses;data integration;data platform;Data Provenance;Data Science;Data Set;data sharing;data standards;deep learning;Development;digital pathology;Documentation;Elements;Emerging Technologies;Ensure;epigenome;Evaluation;experience;FAIR principles;flexibility;Foundations;Generations;Guidelines;Heart;Heterogeneity;high dimensionality;high throughput screening;High-Throughput Nucleotide Sequencing;Human;Image;Image Analysis;Immunohistochemistry;Immunology;in situ sequencing;Individual;innovation;interest;interoperability;Lead;Leadership;Maps;mathematical model;meetings;member;Metadata;method development;Methods;Modeling;Modernization;multi-scale imaging data;multidimensional data;multiple omics;Muscle;Normal tissue morphology;Ontology;Organoids;Policies;Population;Procedures;Process;public repository;Race;repository;Reproducibility;Resolution;senescence;senescent cell;sex;simulation;single cell analysis;single cell ATAC-seq;single-cell RNA sequencing;Skin;Specific qualifier value;Specimen;statistics;Structure of parenchyma of lung;System;Time;tissue mapping;Tissues;tool;transcriptome;transcriptomics;United States National Institutes of Health;Update;Validation;Visualization

PROJECT_TITLE: Data Analysis Core


ORG_CITY: IOWA CITY

ORG_NAME: IOWA CITY VA MEDICAL CENTER

ORG_STATE: IA

PHR: MS is a relevant medical problem faced by Veterans and understanding the factors responsible for disease predisposition as well as progression will help in the development of better treatment options for MS. Recent clinical studies in MS patients have provided a strong case for the role of the gut microbiome in the pathobiology of MS. However, the mechanism through which gut microbiota might predispose or protect form MS is unknown. Thus, our proposal on understanding the mechanisms through which the gut bacteria lacking can modulate disease in MS patients will be an essential step in that direction. A better understanding of the same might lead to discovery of novel diagnostic and prognostic markers as well as development of novel treatment options for MS patients.

PI_NAMEs: MANGALAM, ASHUTOSH KUMAR (contact)

PROJECT_TERMS: 2'-Deoxythymidine;Animal Model;Anti-Inflammatory Agents;Bacteria;bench to bedside;Biological Markers;biomarker identification;Circulation;Cities;Clinic;Clinical;Clinical Course of Disease;Clinical Medicine;Clinical Research;cohort;commensal bacteria;daidzein;Data;Development;diagnostic biomarker;Diet;dietary;Disease;DNA;dysbiosis;Equilibrium;equol;Experimental Autoimmune Encephalomyelitis;Extravasation;Feces;Fiber;Generations;Genes;Goals;gut bacteria;gut dysbiosis;gut microbiome;gut microbiota;Homeostasis;Immune;Immune response;in vivo;Indigenous;Inflammation;Inflammation Mediators;Inflammatory;inflammatory milieu;Inflammatory Response;intestinal epithelium;Intestinal permeability;Iowa;Knowledge;Leaky Gut;Link;Mediating;Mediator;Medical;Metabolism;Modeling;mouse model;Mucous Membrane;Multiple Sclerosis;multiple sclerosis patient;novel;novel diagnostics;Outcome;pathobiont;Pathogenesis;Pathway interactions;Patient Recruitments;Patients;Phase;Phytoestrogens;potential biomarker;Predisposition;Production;Prognostic Marker;Reporting;Research;Role;Sampling;Serum;Side;stool sample;Surface;symbiont;Syndrome;Testing;Therapeutic;therapeutic target;Translating;translational potential;Urine;Veterans

PROJECT_TITLE: Effect of Gut Microbiome Dysbiosis in the Pathobiology of Multiple Sclerosis


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Hematology;Lung;Precision Medicine;Prevention;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PHR: PROJECT NARRATIVE Respiratory complications after stem cell transplantation remain unacceptably common and are associated with substantial patient suffering, healthcare utilization, and mortality. In this proposal, we explore how best to predict which patients develop Acute Respiratory Distress Syndrome (ARDS) – one of the most severe forms of respiratory failure – after transplant and use these clinical prediction tools to better study the mechanism of ARDS development through a novel analytic technique (metabolomics). We will then combine clinical and metabolomics data to help identify subgroups of patients who may benefit from targeted preventative interventions, the implementation of which will be the goal of future projects.

PI_NAMEs: YADAV, HEMANG  (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Acute Disease;Acute Respiratory Distress Syndrome;Address;analytical tool;Area;Biological;Biological Markers;career development;Caring;Clinical;clinical predictors;Complex;Complication;computer studies;Computing Methodologies;Critical Care;Data;Death Rate;Development;Development Plans;effective therapy;Electronic Health Record;endophenotype;Environment;Exclusion;experience;Functional disorder;Funding;Future;Goals;health care service utilization;Heart Diseases;Hematologic Neoplasms;Hematological Disease;Hematopoietic Stem Cell Transplantation;high risk;Hospitals;improved;improved outcome;Informatics;Infrastructure;innovation;Interdisciplinary Study;Investigation;Knowledge;Lung;Lung Diseases;Lung Transplantation;Machine Learning;Medical;Mentors;Mentorship;metabolomics;Mission;Modeling;mortality;Nature;novel;Operative Surgical Procedures;Pathway interactions;Patient Recruitments;patient subsets;Patient-Focused Outcomes;Patients;personalized approach;Phenotype;Physiological;Plasma;Population;post-transplant;precision medicine;predictive modeling;predictive tools;prevent;Prevention strategy;preventive intervention;prognostic;programs;prospective;Reproducibility;Research;Research Methodology;Research Personnel;respiratory;Respiratory Failure;Risk;Risk Factors;risk prediction;risk prediction model;Role;Scientist;skills;statistics;Stem cell transplant;success;Syndrome;System;Systems Biology;Techniques;Time;Training;translational physician;Translational Research;translational scientist;translational study;transplant centers;Transplant Recipients;Transplantation;United States National Institutes of Health;Work

PROJECT_TITLE: Predicting and Preventing Acute Respiratory Distress Syndrome after Hematopoietic Stem Cell Transplantation

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Lupus;Prevention;Telehealth

ORG_CITY: BOSTON

ORG_NAME: TUFTS MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE While advances in the treatment of systemic lupus erythematous (SLE), a chronic autoimmune condition, have reduced mortality, quality of life for individuals with the disease remains poor, largely driven by fatigue. SLE- related fatigue is often resistant to medical therapy and studies suggest biologic, behavioral, and psychosocial drivers. The proposed research project will develop and pilot test a peer coaching intervention to holistically address this critical unmet need of patients with SLE.

PI_NAMEs: KASTURI, SHANTHINI  (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Affect;Attention;Autoimmune Diseases;Award;behavior change;Behavior Therapy;Behavioral;behavioral clinical trial;Behavioral trial;Biological;career;Chronic;Clinical Trials Design;Conduct Clinical Trials;Control Groups;design;Development;Dimensions;Disease;Disease Outcome;Education;efficacy outcomes;efficacy testing;efficacy trial;Enrollment;Etiology;Evaluation;evidence base;experience;Fatigue;feasibility testing;Future;Goals;Health behavior;health related quality of life;Health Technology;impaired productivity;improved;improved outcome;Individual;Informatics;Institution;Intervention;Intervention Trial;Knowledge;Lupus;Measurement;Mediator;Medical;Medical center;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;method development;Methodology;mHealth;mhealth interventions;Mobile Health Application;mortality;motivational enhancement therapy;multi-site trial;Nonpharmacologic Therapy;Observational Study;Outcome Measure;patient engagement;patient oriented;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;peer;peer coaching;Persons;physical inactivity;pilot test;pilot trial;primary outcome;programs;prospective;psychologic;Psychology;psychosocial;Psychosocial Assessment and Care;Quality of life;Randomized;Randomized, Controlled Trials;Refractory;Research;Research Methodology;Research Personnel;Research Project Grants;Resistance;Rheumatism;rheumatologist;Scientist;secondary outcome;Self Determination;Self Efficacy;Self Management;skills;success;Symptoms;Systemic Lupus Erythematosus;Techniques;Testing;theories;therapy design;therapy development;tool;Training;treatment as usual;Unemployment;United States National Institutes of Health;user centered design;Validation;Work

PROJECT_TITLE: Targeted Peer Coaching to Reduce Fatigue in Lupus: A Patient-Centered Behavioral Intervention

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


PI_NAMEs: NIXON, ANDREW B. (contact)

PROJECT_TERMS: 18 year old;Adult;age group;aging related disease;ATAC-seq;Atherosclerosis;Atlases;beta-Galactosidase;Biological;Biological Assay;Biological Markers;biomarker identification;Blood;blood fractionation;Bronchoalveolar Lavage;Cell Aging;cell injury;Cell Nucleus;cell type;Cells;Cerebrospinal Fluid;Childhood;chromatin immunoprecipitation;Chronic Disease;Clinical Research;Collaborations;Colon;Complex;Data;Data Analyses;Development;Dimensions;efficacy testing;Elements;Ensure;Environment;Enzyme-Linked Immunosorbent Assay;Epigenetic Process;Evaluation;experience;fetal;Flow Cytometry;Foundations;functional genomics;Generations;genotoxicity;Genus Mentha;Goals;Growth;Heart;Heterogeneity;high dimensionality;histone modification;Human;Hypoxia;Immune;In Vitro;Infant;Intervention;Lung;Malignant Neoplasms;Maps;Measurement;Measures;Methods;Microfluidics;mitochondrial dysfunction;Modeling;Molecular;Morphology;multimodality;multiple omics;Muscle;Nerve Degeneration;Normal tissue morphology;novel;novel therapeutics;nutrient deprivation;older adult;Organ;Organoids;Phenotype;Prevention;Proteins;Pulmonary Fibrosis;Recording of previous events;Research;Research Personnel;Resolution;Resources;response;Saliva;Sampling;Science;Scientist;senescence;senescence associated secretory phenotype;senescent cell;Skin;Spatial Distribution;Stains;Standardization;stressor;Structure of parenchyma of lung;System;Technology;telomere;Tissue atlas;Tissue Banks;tissue mapping;Tissue Preservation;Tissues;tool;TP53 gene;transcriptome sequencing;transcriptomics;Urine;Work;wound healing;young adult

PROJECT_TITLE: Biological Analysis Core


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Genetics;Human Genome;Mental Health;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Epigenetic pathways allow for multiple cell identities to arise from a single genome and are critical in the brain, where their improper functioning can cause mental retardation, cognitive decline, and psychiatric disorders. In social insects, the same genome specifies different castes that display dramatic differences in various types of social behavior, including aggression and dominance relationships. I propose to use the ant Harpegnathos, where adult ants can switch between different behavioral states, to discover fundamental rules on how epigenetic pathways regulate brain function and behavioral plasticity.

PI_NAMEs: BONASIO, ROBERTO  (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: Adult;Aggressive behavior;Antibodies;Ants;Behavior;Behavior Disorders;Behavioral;Behavioral Assay;behavioral genomics;behavioral plasticity;Biochemical;Biological Models;Brain;Castes;Cells;Chromatin;Chromatin Structure;Cleavage Under Targets and Release Using Nuclease;Cues;Data;Discipline of Nursing;egg;Epigenetic Process;epigenetic regulation;ERG gene;experience;experimental study;functional genomics;Gene Expression;Genes;genetic approach;genetic manipulation;Genetic Transcription;Genome;Genomic approach;Goals;Gonadotropin Hormone Releasing Hormone;Homologous Gene;Human;Immunofluorescence Immunologic;Impaired cognition;In Situ Hybridization;in vivo;Insecta;insight;Mammals;Mental disorders;Mental Retardation;Metabolism;Modeling;Molecular;Neurodevelopmental Disorder;Neurons;Neuropeptides;Pathway interactions;pharmacologic;Phenotype;Physiology;prevent;Process;programs;Proteins;Publishing;Regulation;Repression;Reproduction;response;Role;single-cell RNA sequencing;social;Social Behavior;Social Environment;Specific qualifier value;Testing;transcription factor;transcriptome sequencing;Vasopressin Receptor;Vasopressins;Work

PROJECT_TITLE: Epigenetic regulation of social and behavioral plasticity in ants

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: MISSOULA

ORG_NAME: UNIVERSITY OF MONTANA

ORG_STATE: MT

PHR: PROJECT NARRATIVE The Montana Pediatric Clinical Trials Site (MPCTS) at the University of Montana has been an effective member of the ECHO IDeA States Pediatric Clinical Trials Network (ISPCTN). Prior to MPCTS, few pediatric clinical trials and even fewer in ECHO priority areas had been conducted in the state of Montana. As we look toward the future, our objective is now to build on these successes and expand the reach of ECHO ISPCTN clinical trials into rural and underserved areas in Montana.

PI_NAMEs: SMITH, PAUL  (contact)

PROGRAM_OFFICER_NAME: RAJU, TONSE N

PROJECT_TERMS: Area;Biometry;Board Certification;care providers;care systems;Caring;Censuses;Center for Translational Science Activities;Child;Child Health;Childhood;Chronic;Clinical;Clinical Research;clinical research site;clinical trial protocol;Clinical Trials;Clinical Trials Network;Collaborations;Communities;community engagement;Community Health;Complex;Computers;Consultations;cost;Data;Databases;Dedications;design;Development;Development Plans;Diabetes Mellitus;Disease;Ensure;Epidemiologist;experience;Family Practice;Federally Qualified Health Center;Funding;Future;Geography;Goals;Group Practice;Growth;Health;health care disparity;Health Personnel;Health Sciences;Healthcare;Hour;improved;Infrastructure;innovation;Inpatients;Institution;Laboratories;Leadership;leadership development;Malignant Neoplasms;Manuscripts;Medical;Medicine;member;Mentorship;Monitor;Montana;Multi-Institutional Clinical Trial;Multicenter Studies;Native American population;neurodevelopment;Nurses;Nursing Research;Obesity;operation;Outpatients;outreach;Participant;Pathway interactions;Patient Recruitments;pediatrician;Persons;Pharmacy facility;Phase;Population;Positioning Attribute;Poverty;Principal Investigator;Process;programs;protocol development;Public Health Schools;Quality of life;recruit;Research;Research Design;Research Personnel;Residencies;Resources;Risk;Role;Rural;rural area;Rural Community;Rural Population;Scientist;Secure;senior faculty;Services;Site;skill acquisition;Structure;success;Teacher Professional Development;telehealth;Telemedicine;tertiary care;Travel;tribal community;underserved area;underserved community;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Montana Pediatric Clinical Trials Site


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Neurosciences;Opioids;Pain Research;Patient Safety;Prevention

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative  The NIH created the Helping to End Addiction Long-term (HEAL) initiative to speed scientiﬁc solutions to the national opioid public health crisis. As part of the HEAL initiative, the HEAL Effectiveness Research Network (ERN) was established to conduct comparative effectiveness trials for prevention and management of pain, while reducing risk of addiction. The University of Utah will provide data coordination support for these trials, leading to more effective management of acute and chronic pain while reducing the risk of opioid addiction.

PI_NAMEs: DWYER, JAMIE P.;SWARD, KATHERINE ANN;WATT, KEVIN M (contact)

PROGRAM_OFFICER_NAME: VALLEJO, YOLANDA F

PROJECT_TERMS: Acute pain management;addiction;Award;chronic pain;Clinical;Clinical Trials;Clinical Trials Data Monitoring Committees;Clinical Trials Network;Collaborations;Collection;Common Data Element;comparative effectiveness trial;Data;Data Analyses;Data Collection;data ecosystem;data management;Data Set;data sharing;Databases;Deposition;design;Development;Dose;effectiveness research;Funding;Future;Helping to End Addiction Long-term;Infrastructure;innovation;Institution;Institutional Review Boards;Meta-Analysis;Monitor;National Center for Advancing Translational Sciences;Nature;Opiate Addiction;Opioid;Outcome;Pain management;Phase;Preparation;prevention effectiveness trial;Principal Investigator;Process;programs;Protocols documentation;Public Health;Publications;Quality Control;Randomized;recruit;Regimen;Reporting;repository;Research;Research Personnel;Resources;response;Risk Assessment;Risk Reduction;Safety;Sickle Cell Anemia;Speed;success;System;Testing;Training;Translational Research;U-Series Cooperative Agreements;United States National Institutes of Health;Universities;Utah;Work;Writing

PROJECT_TITLE: HEAL ERN: Data Coordinating Resource Center


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Esophageal Cancer;Genetics;Human Genome;Infectious Diseases;Prevention;Rare Diseases;Stomach Cancer

ORG_CITY: NEW YORK

ORG_DEPT: SURGERY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE To address fundamental questions regarding the cell-of-origin of distinct classes of gastric cancer, we will integrate novel mouse models, organotypic cultures of human and mouse cells using state- of-the-art single cell profiling and spatial transcriptional analyses. We will also explore the related issue of disease development by defining key transcriptional mediators of the progression to gastric cancer and then perform experimental validation. Taken together, our studies will address and resolve longstanding debates over the origins of gastric cancer while also defining possible targets to prevent cancer initiation.

PI_NAMEs: MANIATIS, SILAS ;NOWICKI-OSUCH, KAROL PIOTR;RYEOM, SANDRA  (contact)

PROGRAM_OFFICER_NAME: YASSIN, RIHAB R

PROJECT_TERMS: Address;angiogenesis;Angiogenic Factor;Atlases;Attenuated;Cadherins;Cancer Etiology;cancer initiation;candidate validation;CD44 gene;cell type;Cells;Cessation of life;Characteristics;Chromatin;Chromosomal Instability;Collaborations;Complex;Coupled;Data;Development;dietary;dietary nitrate;Diffuse;Diffuse gastric cancer;Disease;DNA Sequence Alteration;E-Cadherin;Endothelial Cells;Engineering;Environmental Exposure;Environmental Risk Factor;Epigenetic Process;epigenomics;Epithelial Cells;Epithelium;Esophageal Adenocarcinoma;Esophagogastric Junction;Esophagus;Evolution;Exposure to;functional genomics;Future;gastric cancer prevention;gastric corpus;gastric intestinal metaplasia;gastric tumorigenesis;gastroesophageal adenocarcinoma;Gastrointestinal tract structure;Gene Expression Profiling;Genetic;Genetic Transcription;Genetically Engineered Mouse;genome editing;Genome Stability;genomic aberrations;Genomics;Helicobacter;Helicobacter Infections;Helicobacter pylori;Histologic;Human;human tissue;Immune;In Vitro;in vivo;Individual;insight;Intervention;Intestines;Lesion;Link;Malignant - descriptor;Malignant neoplasm of esophagus;Malignant Neoplasms;malignant stomach neoplasm;Maps;Mediating;Mediator;member;Modeling;Molecular;molecular subtypes;mouse model;multiple omics;Mus;Mutation;Myeloid Cells;Myeloid-derived suppressor cells;Neoplasms;neoplastic;Nerve Growth Factors;Nitrates;Nomenclature;novel;Organoids;Pathway interactions;Phenotype;Play;Population;Premalignant Cell;prevent;Process;programs;Resources;Role;Sampling;Signal Transduction;single cell analysis;single cell technology;Stomach;stomach cardia;System;Technology;Testing;Time;Tissue Sample;Tissues;tool;TP53 gene;transcriptomic profiling;transcriptomics;Tumor Expansion;tumor initiation;tumor progression;Tumor Promotion;Tumor Suppressor Proteins;Uncertainty;Validation;Variant

PROJECT_TITLE: Initiation of Diffuse and Intestinal Non-Cardia Gastric Cancer


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Our lab uses de novo protein design to test the principles of protein structure and function – if we understand proteins we should be able to design them from scratch. We also study the structure and inhibition of M2 and E, transmembrane proton transporters from influenza and coronaviruses to enable the design of future therapeutics.

PI_NAMEs: DEGRADO, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Alkali Metals;Amantadine;Amantadine resistance;Amino Acids;Binding Proteins;Computing Methodologies;Coronavirus;Crystallography;design;Drug Design;Future;Hydration status;in vivo;Influenza;Influenza A virus;Ion Channel;Ions;Membrane;Membrane Proteins;Metalloporphyrins;Movement;Nutrient;Pathway interactions;Pharmaceutical Preparations;Protein Engineering;protein function;protein structure;Proteins;Protons;resistant strain;small molecule;Stretching;Structure;Testing;Therapeutic;Viral;Virus;Water;Work

PROJECT_TITLE: Deciphering the relationship between structure, dynamics and function in helical bundle proteins

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Electronic Nicotine Delivery Systems;Genetics;Lung;Tobacco

ORG_DEPT: PHYSIOLOGY

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Narrative The use of e-cigarettes is increasing, and the presence of fruit and dessert flavors in e-liquid is attracting people to begin using them. We will study the effect of flavored constituents and e-cigarette aerosols in alveolar epithelial cells. In addition, we will determine the mechanism of cell and lung injury induced by this exposure to identify novel therapeutic targets.

PI_NAMEs: KOSMIDER, BEATA  (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Adenoviruses;Aerosols;Alveolar;alveolar epithelium;alveolar type II cell;Cell Death;Cell Differentiation process;cell injury;Cell Physiology;Cells;Centers for Disease Control and Prevention (U.S.);Cessation of life;Chronic;cigarette smoke;Computer Models;Cytoprotection;Data;Development;Devices;DNA Damage;e-cigarette aerosols;Electronic cigarette;electronic cigarette use;electronic liquid;Epithelial Cells;Epithelium;Exposure to;Family;Flavoring;Food;Fruit;Functional disorder;Gases;Goals;Histones;Human;Impairment;improved;Ingestion;Inhalation;injured airway;Injury;Knockout Mice;Knowledge;Location;Lung;lung injury;lung regeneration;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Mus;National Institute of Environmental Health Sciences;new therapeutic target;Nicotine;novel;Nuclear;PARK7 gene;Particulate;Persons;Phase;Predisposition;Production;Propylene Glycols;Publishing;Pulmonary Emphysema;Pulmonary Surfactants;Reporting;Respiration;Respiratory physiology;response;Risk;Role;Testing;Time;Toxic effect;Transcriptional Regulation;treatment strategy;vaping;vegetable glycerin;Wild Type Mouse

PROJECT_TITLE: Alveolar epithelial cell dysfunction induced by flavored e-cigarette aerosols


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Improving Outcomes in Chronic Intestinal Failure Using the ECHO Model™: The LIFT- ECHO Last Mile Project Patients with devastating chronic intestinal failure can survive only with parenteral nutrition delivered through an intravenous catheter. This care is very complex and requires expert physicians operating in multi-disciplinary teams. This project investigates whether intestinal failure patient outcomes can be improved by providing their non-expert physicians with virtual multi-disciplinary support and tele-learning.

PI_NAMEs: IYER, KISHORE R (contact)

PROGRAM_OFFICER_NAME: SIMPSON, MATTHEW

PROJECT_TITLE: Improving Outcomes in Chronic Intestinal Failure Using the ECHO Model: The LIFT-ECHO Last Mile Project

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

PHR: These studies will help us understand how and why stem cells divide too much in psoriasis. Understanding how stem cells divide abnormally in disease will lead to novel therapies to manipulate stem cell divisions for the treatment of skin ulcers (too few stem cells), skin cancer (too many ‘cancer’ stem cells), and psoriasis (unbalanced production of stem and progenitor cells). This research has relevance to Veterans’ health and to the cost of care. The health of Veterans with psoriasis is negatively impacted, compared to those with psoriasis in the US population, due to the effects of Veteran lifestyles (stress, PTSD, alcohol and tobacco use) on the severity of psoriasis. Psoriasis is a large economic burden for both the afflicted Veteran and the VA healthcare system. In addition, Veterans are at greater risk for skin ulcerations (a diabetic complication) and some are at increased risk for skin cancer.

PI_NAMEs: GHADIALLY, RUBY  (contact)

PROJECT_TERMS: Address;Adult;Alcohol consumption;aldehyde dehydrogenases;Antibodies;Behavior;Benign;Biological Response Modifier Therapy;Bromodeoxyuridine;cancer cell;cancer stem cell;care costs;CD44 gene;cell behavior;Cell Count;Cell Cycle;Cell Cycle Kinetics;Cell division;Cells;Complications of Diabetes Mellitus;conventional therapy;design;Development;differential expression;Disease;Economic Burden;Epidermis;Equilibrium;Flow Cytometry;Future;Generations;Genes;Goals;Health;Healthcare Systems;Homeostasis;Human;Immune;Immune System Diseases;Immunofluorescence Immunologic;improved;In Vitro;Inflammatory;Interleukins;keratinocyte;Kinetics;Life Style;live cell imaging;mathematical model;Molecular;neutralizing antibody;novel;novel therapeutics;Oncogenic;Organ Culture Techniques;Pathway interactions;Population;Post-Traumatic Stress Disorders;Preparation;prevent;Production;progenitor;Propidium Diiodide;Proteins;Psoriasis;Recombinant Proteins;Reporting;Research;Risk;Role;Severities;Signal Pathway;Skin;Skin Cancer;skin ulcer;Stains;stem;stem cell division;stem cell self renewal;stem cells;Stress;targeted treatment;TFRC gene;Therapeutic;Tobacco use;Transcript;transcriptome sequencing;Veterans;wound healing

PROJECT_TITLE: The role of IL17A and keratinocyte stem cells in human psoriasis.


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Substance Misuse

ORG_CITY: CHARLESTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) are chronic and debilitating psychiatric conditions that frequently co-occur. The proposed study will test the ability of oxytocin to augment an integrated cognitive-behavioral treatment (Concurrent Treatment of PTSD and Substance Use Disorders using Prolonged Exposure; COPE) to significantly reduce AUD and PTSD symptoms concurrently. This study has the potential to improve patient care outcomes, transform clinical practice, advance the science of comorbidity, and identify mechanisms underlying improved outcomes.

PI_NAMEs: BACK, SUDIE E (contact);FLANAGAN, JULIANNE CHRISTINA

PROGRAM_OFFICER_NAME: FALK, DANIEL EVAN

PROJECT_TERMS: Acceleration;Address;Aftercare;alcohol behavior;Alcohol consumption;alcohol response;alcohol use disorder;Alcohols;Animals;Area;associated symptom;Back;Behavior;Behavioral;Biological Markers;blood oxygen level dependent;care outcomes;Chronic;Clinic;clinical outcome measures;clinical practice;Clinical Research;Cognitive;Cognitive Therapy;Collaborations;comorbidity;craving;Cues;Data;disability;Disease;Double-Blind Method;Economic Burden;effective therapy;efficacy evaluation;Ethanol;evidence base;Exposure to;Extinction;Fright;Functional disorder;Functional Magnetic Resonance Imaging;General Population;health care service utilization;Health Expenditures;Human;improved;improved outcome;Individual;innovation;insight;Intervention;Investigation;Knowledge;Manuals;Measures;Mental Health;military veteran;Mission;Morbidity - disease rate;mortality;Motivation;multidisciplinary;National Institute on Alcohol Abuse and Alcoholism;neurobiological mechanism;Neurobiology;neuroimaging;Neuropeptides;novel drug combination;Oxytocin;Participant;Patient Care;Patient Self-Report;Pharmacological Treatment;Pharmacotherapy;physical conditioning;Pilot Projects;placebo controlled study;Placebos;Post-Traumatic Stress Disorders;preclinical study;Prevalence;psychosocial;Psychotherapy;Public Health;Qualifying;Randomized;randomized placebo controlled study;Randomized, Controlled Trials;reduce symptoms;reduced alcohol use;Relapse;Research;Research Design;response;Risk;Science;Self Administration;social cognition;Standardization;Strategic Planning;Substance Use Disorder;Symptoms;Techniques;Testing;Therapeutic Intervention;Time;timeline;Translating;Trauma;treatment effect;treatment optimization;Treatment outcome;Trust;Veterans;Withdrawal Symptom

PROJECT_TITLE: Oxytocin to Enhance Integrated Exposure-Based Treatment of Co-occurring Alcohol Use Disorder and PTSD

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: CHAMPAIGN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Narrative Aneuploidy, mainly due to the defects of homologous chromosome segregation, is a common cause of human diseases, including infertility, miscarriage, and birth defects. The research proposed here will elucidate the 4D genome organization of meiotic chromosomes for both males and females, which provides insight information of meiotic gene regulation and homologous chromosome pairing and segregation. A better understanding of meiotic chromosome structure will help us elucidate the abnormal chromosome behaviors and shed light on the diagnose and treatment of infertility and aneuploidy-induced diseases.

PI_NAMEs: QIAO, HUANYU  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: 3-Dimensional;Adopted;Aneuploidy;Architecture;Behavior;Biophysics;Chromatin;Chromatin Loop;Chromosome abnormality;Chromosome Condensation;chromosome conformation capture;Chromosome Pairing;Chromosome Segregation;Chromosome Structures;Chromosomes;cohesin;Congenital Abnormality;Data;Defect;Development;Diagnosis;Disease;DNA;Down's Syndrome;Embryonic Development;Euchromatin;Female;Fertility;flexibility;Fluorescent in Situ Hybridization;Frequencies;Gender;Gene Expression;Gene Expression Regulation;Genetic Recombination;Genetic Transcription;Genome;Germ Cells;Germ Lines;Goals;Hi-C;human disease;Infertility;infertility treatment;innovation;insight;Investigation;Knowledge;Maintenance;male;Maps;Measurable;Measurement;Measures;Mechanics;Mediating;Meiosis;Meiotic Prophase I;Metaphase;Methods;Micromanipulation;Molecular Conformation;Mus;mutant;nanonewton;Oocytes;Outcome;Paper;Prophase;Proteins;Reporting;Research;Role;segregation;sex;Sex Differences;sexual dimorphism;Shapes;single-cell RNA sequencing;spatiotemporal;Spermatocytes;Spermiogenesis;Spontaneous abortion;Structure;Techniques;Testing;transcriptome;transcriptome sequencing;Visualization;Wild Type Mouse;Work

PROJECT_TITLE: Micromechanical basis of meiotic chromosome condensation and architecture

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Neurosciences

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative Resting-state functional magnetic resonance imaging (rsfMRI) has been widely used to chart functional connectivity and dynamics of large-scale brain networks in both patient groups and healthy populations. The major goal of this project is to develop a rsfMRI-based arousal measure and elucidate the contributions of arousal-related factors to rsfMRI-based connectivity/dynamics measurements. The proposed research is relevant to public health because the outcomes are expected to improve the rsfMRI tool for noninvasive quantifications of brain connectivity and dynamics and promote its applications in various brain diseases.

PI_NAMEs: LIU, XIAO  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Affect;Area;Arousal;base;Behavior;behavior measurement;Behavioral;Big Data;Brain;brain based;Brain Diseases;Brain Mapping;Cardiac;Clinical Research;Cognitive;connectome;Data;Data Analyses;Electroencephalography;Event;experience;experimental study;Functional disorder;Functional Magnetic Resonance Imaging;Future;Goals;Head;Human;improved;Individual Differences;innovation;insight;interest;Knowledge;Lead;Link;Maps;Measurement;Measures;Mediating;Motion;Motor;neural;neuroimaging;neurophysiology;Neurosciences Research;Noise;novel;Outcome;Patients;Physiological;Physiology;Population;Positioning Attribute;Public Health;Qualifying;Regulation;Research;Research Personnel;Research Project Grants;respiratory;Rest;Risk Taking;Role;Sensory;Signal Transduction;spatiotemporal;Time;tool;trait;Work

PROJECT_TITLE: The role of brain arousal in resting-state functional MRI

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ORG_CITY: College Station

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

ORG_STATE: TX

PHR: NARRATIVE Parkinson disease (PD) is a severe terminal neurological disorder that affects millions of people around the world. Although the cause of PD is unclear, this pathology is directly linked to aggregation of α-synuclein. In this proposal, our central goal is to determine basic mechanisms by which lipids change structural organization of α-Syn aggregates and elucidate the relationship between oligomer structure and toxicity.

PI_NAMEs: KUROUSKI, DMITRY  (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Affect;alpha synuclein;Area;Biophysics;Brain;Corpus striatum structure;Development;dopaminergic neuron;Goals;imaging approach;Individual;innovation;Label;Link;lipid metabolism;Lipids;Membrane;Midbrain structure;Mus;Nervous System Disorder;Neurodegenerative Disorders;Neurons;Parkinson Disease;Pathology;Persons;Plasma;Proteins;Regulation;Secondary Protein Structure;Structure;Synaptic Vesicles;Toxic effect;trafficking;Work

PROJECT_TITLE: Biophysical determination of the underlying cause of α-Syn oligomer toxicity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Transcranial magnetic stimulation (TMS) is an effective antidepressant treatment which can focally modulate brain circuits. Using the human connectome as a wiring diagram, can now map each TMS site to an underlying circuit. My preliminary data show that stimulating different circuits can selectively modulate different symptom clusters. The current proposal aims to expand on this finding to develop personalized TMS targeting approaches based on symptoms, behavioral tasks, and brain connectivity.

PI_NAMEs: SIDDIQI, SHAN  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Address;Anatomy;anti-depressive agents;Anxiety;Beck depression inventory;Behavior;Behavioral;Behavioral Assay;behavioral phenotyping;Biometry;Brain;brain based;career development;Clinical;Clinical Trials;Clinical Trials Design;Cluster Analysis;Complement;Conflict (Psychology);conflict resolution;connectome;Data;Data Science;Data Set;data-driven model;Databases;depressive symptoms;Development Plans;Diagnostic;Dimensions;effective therapy;electric field;Elements;Emotional;Equipment and supply inventories;experience;FDA approved;Foundations;Goals;heuristics;Human;improved;Individual;individual patient;inter-individual variation;Israel;Link;Location;Magnetic Resonance Imaging;Major Depressive Disorder;Maps;Medical center;Mental Depression;Mental disorders;Mentorship;Methods;Modeling;Monitor;multidisciplinary;Nature;neuropsychiatry;neuroregulation;Outcome;Participant;Patient Self-Report;Patients;personalized approach;Phenotype;Procedures;prospective;Prospective Studies;Psychiatry;Randomized;randomized trial;Request for Proposals;Research;Research Domain Criteria;Research Methodology;Research Personnel;Scalp structure;Site;skills;symptom cluster;Symptoms;Task Performances;Taxonomy;Testing;Therapeutic;therapeutic target;Training;Training Programs;Transcranial magnetic stimulation;Translational Research;treatment-resistant depression;trial comparing;Work

PROJECT_TITLE: Personalized circuit-based neuromodulation targets for depression

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: PROJECT NARRATIVE Genomic resources for the human immunoglobulin loci poorly represent diversity among human populations, limiting our ability to resolve the role of antibody genetic variation in health and disease. This renewal project will build the most comprehensive immunoglobulin genomic dataset to date, with transformative impact on the fields of B cell immunology and immunogenetics. The data generated will (i) shed light on the extent of immunoglobulin diversity worldwide; (ii) establish a framework for linking genetic data to expressed antibody repertoire variation to inform our understanding of V(D)J recombination and seed models of antibody repertoire dynamics in disease; (iii) and substantially augment key databases and research initiatives pushing the frontier of disease genomics and immunology research.

PI_NAMEs: SMITH, MELISSA LAIRD;WATSON, COREY TAYLOR (contact)

PROGRAM_OFFICER_NAME: BREEN, JOSEPH J

PROJECT_TERMS: 2019-nCoV;Adaptive Immune System;Adult;analysis pipeline;Antibodies;Antibody Repertoire;Antibody Response;Antibody-mediated protection;Area;Autoimmunity;Award;B-Lymphocytes;Basic Science;Biomedical Research;Brazil;Catalogs;Clinical;cohort;Collaborations;Collection;Communities;Complex;Data;data access;Data Set;database of Genotypes and Phenotypes;Databases;dbSNP;Deposition;design;Development;Disease;Ensure;ethnic diversity;European;frontier;Genbank;Gene Expression Regulation;General Practitioners;Genes;Genetic;genetic association;Genetic Diseases;Genetic Polymorphism;Genetic Variation;Genome;genome browser;genome resource;genomic data;Genomics;Genotype;Genotype-Tissue Expression Project;Germ Lines;Germ-Line Mutation;Haplotypes;Health;high standard;HIV;Human;Human Genome;Human Resources;IGL@ gene cluster;Immune;Immunogenetics;Immunogenomics;Immunoglobulin A;Immunoglobulin G;Immunoglobulin Genes;immunoglobulin light chain locus;Immunoglobulin M;Immunoglobulins;Immunologic Receptors;Immunology;improved;Individual;Infection;International;Investigation;Knowledge;Light;Link;Malignant Neoplasms;Methods;Modeling;novel;Nucleotides;Oceania;Outcome;Population;Population Heterogeneity;Positioning Attribute;precision medicine;Quantitative Trait Loci;reference genome;Research;Resources;response;Rheumatic Heart Disease;Role;Sampling;Single Nucleotide Polymorphism;South African;Summary Reports;tool;Uganda;Underrepresented Populations;V(D)J Recombination;vaccine response;Variant

PROJECT_TITLE: An ethnically diverse genomic reference resource for the human heavy and light chain immunoglobulin loci


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Studies aimed at understanding the genetic basis of alcoholism have made significant progress in the past five years; it is now clear that many genes contribute relatively small amounts of risk. Studies using rats and mice are also very powerful, however, the tools for translation of findings between species remain poor, limiting progress. We are proposing a novel method to address this problem, which we will develop and test using genetic datasets from humans and rodents that are relevant to alcohol use and abuse.

PI_NAMEs: IM, HAE KYUNG ;PALMER, ABRAHAM A (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Address;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol risk;alcohol use disorder;Alcoholism;Alcohols;Alleles;Architecture;Behavior;Behavioral;Biological;Biological Models;Biological Testing;Brain;Brain Diseases;Cell Physiology;Cessation of life;Chronic;comparative;consumption measures;Data;Data Set;Development;Disease;economic cost;Elasticity;Female;Gene Expression;Genes;Genetic;genetic architecture;Genetic Polymorphism;Genetic Variation;genome wide association study;Genotype;Grant;Heritability;Homologous Gene;Human;Human Genome;improved;Individual;Knowledge;loss of function;male;Methods;Modeling;Molecular;Motivation;Mus;novel;novel strategies;Orthologous Gene;Pathway interactions;Phenotype;phenotypic data;Physiological;polygenic risk score;Population;portability;preference;Prevention;Procedures;Psychiatry;Public Health;Rattus;Research;Risk;Rodent;Rodent Model;Self Administration;Signal Transduction;Single Nucleotide Polymorphism;SNP genotyping;Societies;Sum;Techniques;Testing;Tissues;tool;Training;trait;Transcript;transcriptome;transcriptomics;Translating;Translations;Twin Multiple Birth;Twin Studies;Variant;Weight;Work

PROJECT_TITLE: A Framework for Translating Polygenic Findings Related to Alcohol Use Disorder Across Species

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Lung;Neurosciences;Physical Activity;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Narrative This study will examine the efficacy of a gait training program in chronic stroke survivors who cannot walk independently. We will evaluate them on their cardiovascular, pulmonary, and sensorimotor functions. The results of the proposed study may lead to the development of an effective gait training program for non- ambulatory stroke survivors who need it the most.

PI_NAMEs: LIU, WEN  (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Address;Aerobic Exercise;Affect;American;American Heart Association;American Stroke Association;Blood Pressure;Body Weight;Cardiovascular Diseases;cardiovascular health;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;Categories;Cause of Death;chronic stroke;Clinical;clinical practice;comparison control;comparison intervention;Control Groups;Development;Devices;Diastolic blood pressure;Effectiveness;efficacy evaluation;efficacy trial;Enrollment;Equilibrium;Exercise;exercise intensity;exercise program;experimental group;Frequencies;gait rehabilitation;Glycosylated Hemoglobin;Glycosylated hemoglobin A;Goals;group intervention;Guidelines;Health;Healthcare;Heart Rate;Impairment;improved;Individual;Intervention;Knowledge;LDL Cholesterol Lipoproteins;Leg;Lifelong disability;Lung Diseases;lung health;Measurement;Measures;Metabolic;Metabolic Diseases;mortality;Muscle;Myocardium;Neuronal Plasticity;novel;Outcome Assessment;Patients;Persons;Population;post stroke;psychologic;pulmonary function;Questionnaires;Random Allocation;Randomized;Recommendation;recruit;Recurrence;Rehabilitation therapy;Research;Rest;Risk Management;Sensorimotor functions;Signal Transduction;Stroke;stroke survivor;Text;Training;Training Programs;treadmill;treatment as usual;Vital capacity;Walking

PROJECT_TITLE: Developing a walking exercise program for non-ambulatory stroke survivors

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_CITY: NEWARK

ORG_NAME: NEW JERSEY INSTITUTE OF TECHNOLOGY

ORG_STATE: NJ

PHR: Project Narrative: Our successful R01 discovered 1) the neural mechanistic difference between typically- occurring convergence insufficiency (TYP-CI) and binocularly normal controls and 2) the underlying mechanism of office-based vergence and accommodative therapy (OBVAT) that is effective in remediating symptoms. Adolescent and young adult concussion is considered a substantial health problem in the United States1–3 where our team has shown that about half of patients with persistent post-concussion symptoms have convergence insufficiency (PPCS-CI), 4 causing significant negative impact associated with reading or digital screen-related activities, and is believed to be one factor causing delayed recovery impacting return to school, sports, or work. The results of this randomized clinical trial will impact the lives of adolescents and young adults with PPCS-CI to guide professionals on how to manage and treat those with PPCS-CI by 1) comparing the differences between PPCS-CI and TYP-CI, 2) discovering the neural mechanism of OBVAT for PPCS-CI compared to standard-community concussion care, and 3) determining the effectiveness of 12 one- hour sessions compared to 16 one-hour sessions of OBVAT.

PI_NAMEs: ALVAREZ, TARA LYNN (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: 21 year old;Address;Adolescent and Young Adult;Adult;Age;Automobile Driving;Behavior;Binocular Vision Disorder;Brain;brain behavior;Brain Concussion;Caring;Cerebellar vermis structure;Child;Clinical;Clinical Sciences;Communities;compare effectiveness;comparison control;Convergence Insufficiency;Craniocerebral Trauma;Data;debilitating symptom;Diagnostic;digital;dosage;effective therapy;effectiveness evaluation;Enrollment;Etiology;experimental study;Eye Movements;frontal eye fields;Functional Magnetic Resonance Imaging;Health;Hour;improved;Injury;Link;Measurement;Measures;neural;neuromechanism;neuroregulation;novel therapeutics;Ocular Fixation;oculomotor;Outcome;Outcome Measure;Participant;Pathology;Patients;Performance;point of care;Population;Positioning Attribute;Post-Concussion Syndrome;Preparation;Prevalence;Procedures;Protocols documentation;Publications;Publishing;Ramp;Randomized;randomized, clinical trials;Reading;Recording of previous events;Recovery;remediation;Reporting;Research;response;Saccades;sample fixation;Schools;Severities;Smooth Pursuit;Sports;symptom management;Symptoms;System;Testing;Thalamic structure;Therapeutic;Time;United States;Vision;Visual;visual performance;Work;young adult

PROJECT_TITLE: Functional Mechanism of Neural Control in Post-Concussion Convergence Insufficiency

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


NIH_SPENDING_CATS: Clinical Research;Genetics;Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project narrative We have demonstrated that the Enhanced Detection System for Healthcare Association Transmission (EDS- HAT) detects serious outbreaks that are otherwise unidentified. In this renewal application, we propose to leverage the success of EDS-HAT by adding respiratory viral infections, developing an outbreak detection system that does not rely primarily on whole genome sequencing, and developing advanced genomic analytic tools for improved detection. The results of this research will lead to dramatically increased capacity to detect and interrupt healthcare-associated outbreaks.

PI_NAMEs: HARRISON, LEE H (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: 2019-nCoV;acute care;adjudication;Adult;advanced analytics;Algorithms;analytical method;analytical tool;Area;bacterial genome sequencing;budget impact;Centers for Disease Control and Prevention (U.S.);Childhood;Classification;Clinical;Clinical Data;Clinical Microbiology;Collection;Complex;Computing Methodologies;Data;data mining;Databases;Detection;detection platform;Development;Disease Outbreaks;economic evaluation;Economic Models;Economics;Electronic Health Record;Epidemiology;Evaluation;evidence base;Genes;Genetic;Genome;genome sequencing;genomic epidemiology;Genomics;Goals;Health Care Costs;health care settings;Healthcare;Healthcare Systems;healthcare-associated infections;hospital care;Hospital Costs;Hospitalization;Hospitals;improved;Incidence;Infection;Infection prevention;Infectious Disease Epidemiology;Influenza;innovation;Interruption;Investigation;Laboratories;Link;Machine Learning;Methods;microbial genomics;Minisatellite Repeats;Mobile Genetic Elements;Modeling;Morbidity - disease rate;mortality;neglect;novel;novel strategies;outbreak concern;pathogen;patient safety;Patients;Policies;Prevalence;prevent;Prevention;Prevention program;prospective;Research;Residual state;Resources;respiratory;respiratory infection virus;Respiratory syncytial virus;respiratory virus;Route;Sampling;Seasons;Single Nucleotide Polymorphism;sound;Specimen;success;Synteny;Testing;Time;transmission process;Validation;viral outbreak;Viral Respiratory Tract Infection;viral transmission;Virus;wasting;whole genome

PROJECT_TITLE: Enhanced Detection System for Healthcare-Associated Transmission of Infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-G(90)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Dissemination and Implementation Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Prevention

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE New or worsening cognitive impairment following critical illness is a major public health problem affecting older adults. With the proposed Mentored Career Development Award, I will obtain the additional training in cognitive assessment and implementation science that I need to develop and test a program to screen for and support patients and caregivers suffering from this important complication. I anticipate that the proposed research program could transform care for older adults by improving our ability to predict those at increased risk for post intensive care cognitive impairment and connecting patients and their families with resources that may prevent ongoing cognitive decline.

PI_NAMEs: PALAKSHAPPA, JESSICA ANN (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: Active Learning;Address;Admission activity;Adopted;Adult;Affect;Age;Aging;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease related dementia;Area;beneficiary;Calibration;career;Caregiver Burden;Caregivers;Caring;Clinical Trials;Cognition;Cognitive;cognitive testing;Communication;Complication;Consolidated Framework for Implementation Research;Continuity of Patient Care;Critical Care;Critical Illness;Data;Dedications;Dementia;design;Development;Discipline;Early Intervention;Education;effectiveness/implementation trial;Elderly;Electronic Health Record;Environment;Epidemiology;evidence base;evidence based guidelines;experience;Family;Focus Groups;follow-up;Goals;health belief;Health system;High Prevalence;high risk;high risk population;Impaired cognition;Impairment;implementation science;implementation trial;improved;innovation;Intensive Care;Intensive Care Units;Intervention;Interview;K-Series Research Career Programs;Knowledge;Learning;Link;medical schools;Medicare;Medicare claim;Mentors;Mentorship;Methodology;Methods;mild cognitive impairment;Modeling;modifiable risk;mortality;National Institute on Aging;Nursing Homes;older adult;Participant;patient oriented research;Patients;Persons;Physicians;pilot test;Population;predictive modeling;prevent;primary care provider;programs;Public Health;Qualifying;Recommendation;Research;Research Infrastructure;Research Personnel;Research Priority;Resources;Retrospective cohort study;Risk;Risk Factors;Scientist;screening;screening guidelines;Screening procedure;Severities;Site;skills;Structure;Telephone;Testing;tool;Training;treatment as usual;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Screening for Cognitive Impairment Following Critical Illness: Designing and Testing an Implementation Program to Support High Risk Older Adults

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Clinical Research;Down Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Pediatric;Prevention

ORG_CITY: SEATTLE

ORG_NAME: BENAROYA RESEARCH INST AT VIRGINIA MASON

ORG_STATE: WA

PHR: NARRATIVE Autoimmune disease presents a major health hazard to our population and can be devastating to individual patients. To date, there is no therapy that can prevent or cure autoimmune disease. The proposed studies will investigate how naïve T cells promote the transition from sub-clinical autoimmunity to autoimmune disease, focusing on this transition in individuals at-risk for type 1 diabetes and in individuals with Down syndrome, which is a genetic condition at high-risk for developing autoimmune disease.

PI_NAMEs: BUCKNER, JANE HOYT (contact);LONG, S ALICE

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Address;Autoantigens;Autoimmune;Autoimmune Diseases;autoimmune inflammation;Autoimmune Process;Autoimmunity;autoreactivity;biobank;Biological Assay;Biological Markers;Cell Compartmentation;cell type;Cells;Chromatin;Clinical;cohort;Collaborations;Collection;cost;Data;Diagnosis;Disease;disorder risk;Down's Syndrome;Effector Cell;effector T cell;Environmental Risk Factor;Epigenetic Process;Event;Failure;Fingers;Funding;Genes;Genetic;Genetic Diseases;Genetic Risk;genetic variant;Goals;Health Hazards;high risk;Home;Immune;Immune Tolerance;Immunologics;In Vitro;in vitro Assay;in vivo;Individual;individual patient;Insulin-Dependent Diabetes Mellitus;Knowledge;Leadership;Longitudinal cohort;Longitudinal Studies;Memory;multimodality;Natural History;novel;Nucleic Acid Regulatory Sequences;Pathogenicity;Pathway interactions;Population;pre-clinical;precursor cell;prevent;Process;progression risk;prospective;Prospective cohort;Publishing;Research Design;restraint;Risk;risk variant;Role;sample collection;Sampling;Staging;Surface;T memory cell;T-Lymphocyte;Testing;transcriptome;treatment response;Variant;Work

PROJECT_TITLE: T cells promoting transitions toward autoimmunity


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative Drug discovery remains a cost-, labor-, and time- intensive endeavor with a high failure rate. The proposed work will use genetic diversity found in nature to create a new system for molecular evolution in mammalian cells and deploy it against a high-value drug target. In doing so it will transform our current drug discovery pipeline and create new paths forward to treat human disease.

PI_NAMEs: KOCAK, DANIEL DEWRAN (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Address;Adopted;Animals;antagonist;Archaea;Arrestins;Bacteria;Bacteriophages;Biological Assay;Biology;Cell Line;Cells;Chemicals;clinical development;Clustered Regularly Interspaced Short Palindromic Repeats;computerized data processing;cost;Coupled;Cryoelectron Microscopy;Darkness;Development;direct application;Directed Molecular Evolution;DNA Viruses;DNA-Directed RNA Polymerase;Docking;drug candidate;drug development;drug discovery;Drug Targeting;Endowment;Engineering;Environment;Evolution;extracellular;Failure;Family;Family member;Fertility;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Generations;Genes;Genetic;Genetic Transcription;Genetic Variation;Growth;GTP-Binding Proteins;HTR2A gene;Human;human disease;in silico;In Vitro;Innate Immune System;insight;Interferons;Laboratories;Lead;Libraries;Mammalian Cell;member;Methodology;Methods;Modification;Molecular;Molecular Conformation;Molecular Evolution;nanobodies;Nature;novel;Organism;Orphan;Output;Pharmaceutical Preparations;Plants;pressure;Prokaryotic Cells;Property;Proteins;receptor;Replicon;Ribosomes;RNA;RNA Viruses;serotonin receptor;Signal Transduction;Specificity;Structure;System;Technology;Testing;Tetracyclines;Therapeutic;Therapeutic antibodies;Time;tissue culture;Togaviridae;tool;Trans-Activators;Transducers;Transplantation;Viral;Virus;Work;Yeasts

PROJECT_TITLE: DRUG DISCOVERY BY DIRECTED EVOLUTION IN MAMMALIAN CELLS


NIH_SPENDING_CATS: Clinical Research;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Chronic spontaneous urticaria (CSU) causes symptoms of recurrent itchy hives of unknown origin and leads to significant quality of life impairments and economic burdens. Immune cells in the skin called mast cells play a major role in hives, but why mast cells are more active and how they cause chronic symptoms in CSU is not understood. The proposed studies will investigate how inflammatory signals in the skin activate mast cells to cause more severe itch and hives so that more effective therapies can be found for CSU.

PI_NAMEs: VER HEUL, AARON  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Advisory Committees;Affect;Afferent Neurons;Agonist;Allergens;Allergic Disease;Allergic inflammation;anti-IgE;Antihistamines;Atopic Dermatitis;Automobile Driving;Award;Behavior;Biological Assay;Biological Models;Biology;Biopsy;Cell Physiology;Cells;Chronic;Clinical;Communities;Complement;crosslink;cytokine;Data;debilitating symptom;Disease;Doctor of Philosophy;Economic Burden;effective therapy;Epithelium;Exposure to;Family member;functional genomics;Funding;G-Protein-Coupled Receptors;Gene Expression;Genetic Polymorphism;Genomics;Goals;Histamine;Human;humanized mouse;Hypersensitivity;IgE;Immune;Immune response;Immunoglobulins;Immunology;Impairment;In Vitro;in vitro Assay;in vivo;Inflammatory;insight;instructor;interest;Interleukins;Kinetics;Knockout Mice;Laboratories;mast cell;Mediating;Mediator;Mentors;Microscopy;mouse model;Mus;neuroimmunology;Neuroimmunomodulation;Neurons;Neuropeptides;Neurosciences;novel;novel therapeutics;Orthologous Gene;Pathogenesis;Pathway interactions;Patients;persistent symptom;Pharmaceutical Preparations;Physicians;Play;Population;Postdoctoral Fellow;promoter;Pruritus;Publishing;Quality of life;Records;Recurrence;Research;Research Personnel;Resources;response;Role;Sampling;Scientist;Severities;Signal Transduction;single-cell RNA sequencing;skills;Skin;small molecule;Symptoms;Technical Expertise;Testing;Tissues;Training;Transfection;translational model;two photon microscopy;Universities;Urticaria;Variant;Virulence Factors;Vocational Guidance;Washington;Work;Writing

PROJECT_TITLE: Skin Neuroimmune Mechanisms of Urticarial Itch


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cerebral Palsy;Clinical Research;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rehabilitation

ORG_CITY: BOYS TOWN

ORG_NAME: FATHER FLANAGAN'S BOYS' HOME

ORG_STATE: NE

PHR: PROJECT NARRATIVE Cerebral palsy (CP) results from a perinatal brain injury that instigates lifelong challenges in mobility. The current project will use brain imaging, spinal cord assessments and clinical tests to accelerate the development of new biomarkers that capture the connection between nervous system dysfunction and the altered mobility seen in youth with CP. The new indices developed through this important project will provide unprecedented neurophysiological specificity for developing therapeutic targets for individuals with CP.

PI_NAMEs: KURZ, MAX J (contact)

PROJECT_TERMS: Acceleration;Address;Adolescence;Adult;Affect;Biological Markers;Brain imaging;Cerebral Palsy;Childhood;Clinical;Clinical assessments;Complement;Cortical Cord;Corticospinal Tracts;cost;Coupled;design;Development;Direct Costs;Economic Burden;Electroencephalography;Elements;Environment;Equation;Equilibrium;Esthesia;Exhibits;experience;experimental study;flexibility;foot;Functional disorder;Gait;gray matter;Image;improved;indexing;Individual;innovation;Interneurons;kinematics;Knowledge;Leg;Magnetic Resonance Imaging;Magnetoencephalography;Methods;Modeling;Modernization;Motor;Movement;multimodal neuroimaging;multimodality;Muscle;Musculoskeletal System;Nervous System;neural;neuroimaging;Neurologic;neurophysiology;Neurosciences;novel;novel therapeutics;Participant;Perinatal Brain Injury;Peripheral;Persons;Play;Population;Protocols documentation;Proxy;Resolution;Role;Seminal;Sensory;sensory integration;Sensory Process;Series;Societies;somatosensory;Somatosensory Cortex;spasticity;Specificity;Spinal Cord;Techniques;temporal measurement;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Time;Tissues;United States;white matter;Work;Youth

PROJECT_TITLE: Dynamic Imaging of Cerebral Palsy Gait

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: Relevance to Public Health Meiosis is a specialized set of cell divisions that generate male (sperm) and female (egg) gametes. In females, meiosis is associated with high rates of chromosome segregation errors, which lead to miscarriage, infertility, and developmental disorders such as Down’s syndrome. This project uses mouse oocytes as a model system to understand the basic molecular mechanisms that regulate female meiosis, thereby shedding a light on why this process is notoriously error prone.

PI_NAMEs: BALBOULA, AHMED  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TITLE: Mechanisms underpinning meiotic spindle formation and behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Lung;Networking and Information Technology R&D (NITRD);Patient Safety;Telehealth

ORG_CITY: Murray

ORG_NAME: IHC HEALTH SERVICES, INC.

PHR: PROJECT NARRATIVE Approaches to prolonged invasive mechanical ventilation (IMV), including management of sedation and movement, for patients with respiratory failure may lead to delirium, slower recovery, and poor long term cognitive outcomes. Coordinated spontaneous awakening and breathing trials (C-SAT/SBT) have been shown to improve these outcomes but are underutilized. The goal of this proposal is to use the Consolidated Framework for Implementation Research to understand the barriers and facilitators to implementing strategies for C-SAT/SBT in IMV patients, by evaluating the impact of a Telehealth-Enabled, real-time Audit and feedback for Clinician adHerence (“TEACH”) implementation strategy, to achieve high adherence and measure the impact on ventilator-free days, in a cluster randomized trial.

PI_NAMEs: GRISSOM, COLIN KERST (contact);HOLUBKOV, RICHARD ;SRIVASTAVA, RAJENDU

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: Absence of pain sensation;Acute respiratory failure;Adherence;Adopted;arm;Breathing;candidate identification;care systems;Caring;Clinical;clinical decision support;Clinical effectiveness;Clinical Trials;Cluster randomized trial;Cognitive;Communication;Communities;Complex;Computerized Medical Record;Consolidated Framework for Implementation Research;Critical Care;Critical Illness;dashboard;data sharing;Delirium;Effectiveness;effectiveness/implementation hybrid;effectiveness/implementation trial;Electronics;Event;Evidence based practice;Feedback;follow-up;Goals;Guidelines;health care delivery;Healthcare;Hospitals;Immobilization;implementation barriers;implementation strategy;implementation/effectiveness;improved;improved outcome;Institution;Intensive Care;Intensive Care Units;Interruption;Intervention;Knowledge;Length of Stay;Life;Lung;Measures;Mechanical ventilation;Mechanical Ventilators;Monitor;mortality;Movement;novel;Nurses;Outcome;Oxygen Consumption;Pain;Patient Monitoring;Patient-Focused Outcomes;Patients;Performance;Periodicals;Persons;Physicians;Positioning Attribute;prospective;Protocols documentation;Provider;provider adherence;Randomized;Recommendation;Recovery;remote health care;remote monitoring;remote patient monitoring;Research;respiratory;Respiratory Failure;Risk;Sampling;SARS-CoV-2 exposure;Sedation procedure;Site;System;telehealth;Testing;Time;ventilation;Ventilator;ventilator-associated pneumonia;Work

PROJECT_TITLE: Implementation of Coordinated Spontaneous Awakening and Breathing Trials Using Telehealth-Enabled, Real-Time Audit and Feedback for Clinician AdHerence: A Type II Hybrid Effectiveness-Implementation