NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Tuberculosis (TB) is the world's deadliest infectious disease (other than COVID-19); two keys to reducing this burden of mortality are finding people with undiagnosed TB and providing preventive therapy. Our initial project constructed a “snapshot” of TB transmission in an urban Ugandan community and identified venue-based screening (events held at key locations such as markets) as an efficient case-finding activity. In this renewal, we will conduct a clinical trial to study the implementation and effectiveness of two approaches to venue-based screening and preventive therapy (hotspot-focused and facility-based) with the aim of identifying a feasible strategy to find and prevent TB in peri-urban sub-Saharan Africa.

PI_NAMEs: DOWDY, DAVID WESLEY;KENDALL, EMILY A (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Africa South of the Sahara;Area;authority;Caring;case finding;Catchment Area;Cessation of life;Clinic;Clinical Trials;Communicable Diseases;Communities;comparative effectiveness;compare effectiveness;cost effectiveness;Country;COVID-19;Cross-Over Trials;Data;Detection;Devices;Diagnosis;Diagnostic;Diagnostic Sensitivity;digital;disability-adjusted life years;Disease;Early Diagnosis;effective intervention;Effectiveness;effectiveness/implementation design;effectiveness/implementation hybrid;effectiveness/implementation study;Epidemiology;Event;evidence base;experience;Funding;Future;Geography;Health;Health care facility;Heterogeneity;High Prevalence;Household;implementation measures;implementation/effectiveness;improved;Incidence;incremental cost;incremental cost-effectiveness;Individual;Infrastructure;innovation;Intervention;intervention effect;Link;Location;Maintenance;Marketing;Measures;models and simulation;Morbidity - disease rate;mortality;Mycobacterium tuberculosis;National Heart, Lung, and Blood Institute;Neighborhoods;Notification;novel;Observational Study;operation;Participant;patient oriented;Patient Preferences;Patients;peri-urban;Persons;Population;population based;pragmatic randomized trial;preference;Prevalence;prevent;Preventive therapy;primary outcome;programs;Public Health;Pulmonary Tuberculosis;Randomized;Reading;Regimen;Reporting;Resources;Roentgen Rays;scale up;screening;secondary analysis;Sputum;standard of care;technological innovation;Testing;Thoracic Radiography;Time;Translating;transmission process;Treatment Efficacy;Tuberculosis;Tuberculosis diagnosis;Uganda;Vietnam;Zimbabwe

PROJECT_TITLE: Hotspot versus clinic-based active case finding for TB in Uganda: A pragmatic randomized trial

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Orphan Drug;Pneumonia and Influenza;Prevention;Rare Diseases;Sexually Transmitted Infections;Tuberculosis;Tuberculosis Vaccine;Vaccine Related;Vector-Borne Diseases

ORG_CITY: SAINT LOUIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE: Saint Louis University proposes to continue and expand its service in the NIAID Vaccine and Treatment Evaluation Unit (VTEU) network. SLU aims to help the network achieve its objectives of evaluating vaccines, other preventive biologics, therapeutics, diagnostics, and devices to treat and prevent infectious disease.

PI_NAMEs: HOFT, DANIEL F. (contact)

PROGRAM_OFFICER_NAME: LARKIN, BRENDA D

PROJECT_TERMS: Adenovirus Vector;Adjuvant;Adult;Age;Agreement;Anthrax disease;arboviral disease;Area;Attenuated;BCG Vaccine;Beds;biodefense;Biological Products;Biology;biomarker identification;bioweapon;Birds;Blood;Blood specimen;Childhood;Clinic;Clinical;Clinical Research;Clinical Trials Design;co-infection;Collaborations;Communicable Diseases;Containment;Contracts;Dedications;Dengue Fever;design;Devices;Diagnostic;Disease;Disease Outbreaks;disorder control;disorder prevention;Doctor of Philosophy;efficacy trial;Elderly;Emerging infection;Enrollment;Ensure;Enteral;enteric pathogen;Epidemiology;Evaluation;Evolution;experience;Faculty;first-in-human;Flavivirus;flu;Foundations;Future;Goals;Hepatitis;Hepatitis C virus;Herpes Simplex Virus Vaccines;high risk;HIV;HIV Vaccine Trials Network;Human;Immunity;immunogenicity;Immunology;immunosuppressed;industry partner;Infection;Influenza;Influenza A Virus, H1N1 Subtype;influenza virus strain;influenza virus vaccine;Infrastructure;Inpatients;Institution;Institutional Review Boards;International;investigator-initiated trial;Investments;Knowledge;Laboratories;Leadership;Liver;Malaria;medical schools;Microbiology;Modeling;Molecular;Molecular Biology;Molecular Immunology;Mucous Membrane;Mycobacterium bovis;National Institute of Allergy and Infectious Disease;neglected tropical diseases;new pandemic;Norovirus;novel;novel marker;Nurses;pandemic influenza;Parainfluenza;Parasitic Diseases;pathogen;pathogenic bacteria;pathogenic virus;Patients;Pediatrics;Pharmacists;pharmacokinetics and pharmacodynamics;Phase;Plague;pregnant;prevent;Prevention;Preventive;priority pathogen;Procedures;Process;Protocols documentation;Qualifying;Quarantine;rBCG;Readiness;Recombinants;Reporting;Research;research facility;Research Personnel;Resources;response;Safety;Salmonella;Sampling;Scientist;seasonal influenza;Seasons;Services;Sexually Transmitted Diseases;Simplexvirus;Site;skills;Smallpox;Special Population;Specialist;Standardization;Study models;Subunit Vaccines;Therapeutic;Therapeutic Trials;Tissues;tool;Translational Research;trial design;Tuberculosis;tuberculosis immunity;Tuberculosis Vaccines;Tularemia;United States National Institutes of Health;Universities;Utah;vaccine development;vaccine efficacy;vaccine evaluation;vaccine trial;Vaccines;Vaccinia;vaccinology;Viral;Work;Yellow Fever;Yellow Fever Vaccine;ZIKA;zika fever

PROJECT_TITLE: Vaccine and Treatment Evaluation Unit at Saint Louis University


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetic Testing;Genetics;Human Genome;Lung;Precision Medicine;Prevention;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: 8. Project Narrative Idiopathic pulmonary fibrosis is a disorder characterized by lung scarring and has a prognosis worse than that of most cancers. Improving early detection for idiopathic pulmonary fibrosis is an important public health priority. The prior version of this proposal demonstrated the important role that screening in close relatives can have in detecting early stages of pulmonary fibrosis and this renewal expands upon this work while capitalizing on important new and planned genetic and genomic discoveries.

PI_NAMEs: HUNNINGHAKE, GARY MATTHEW (contact);RABY, BENJAMIN ALEXANDER;ROSAS, IVAN O.

PROJECT_TERMS: Acceleration;Address;Algorithms;antifibrotic treatment;Awareness;biobank;Biology;Candidate Disease Gene;Caring;chest computed tomography;Chromosome Mapping;Clinic;Clinical;clinical practice;Clinical Research;Clinical Trials;cohort;college;Data;Death Rate;Detection;Development;Diagnosis;diagnostic value;Disease;Disease Progression;disorder risk;Early Diagnosis;early screening;Environmental Exposure;ethnic diversity;Ethnic Origin;Ethnic Population;exome;experience;fibrotic lung;First Degree Relative;follow-up;Future;gene discovery;gene network;Genes;Genetic;genetic information;genetic testing;genetic variant;Genetic Variation;Genomic approach;Genomics;Goals;Grant;High Prevalence;high risk;idiopathic pulmonary fibrosis;improved;interest;interstitial;Interstitial Lung Diseases;Length;loss of function;Lung;Malignant Neoplasms;Measures;Medical;Medical Genetics;Medicine;Methods;Modeling;Mucins;multi-racial;Network-based;novel;Pathogenicity;Patients;Pharmacotherapy;Physiological;Play;polygenic risk score;Population;Population Heterogeneity;Positioning Attribute;Predictive Factor;Predisposition;Prevalence;proband;Process;Prognosis;prognostic value;prognostication;promoter;public health priorities;Pulmonary Fibrosis;pulmonary function;pulmonary function decline;Pulmonary function tests;racial diversity;racial population;recruit;Registries;Rejuvenation;Relative Risks;Reproducibility;Risk;risk prediction;Role;Sample Size;screening;Site;telomere;Test Result;Therapeutic Intervention;Trans-Omics for Precision Medicine;transcriptomics;Translational Research;Validation;Variant;Work

PROJECT_TITLE: Clinical Genetics and Screening for Pulmonary Fibrosis

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Lung;Orphan Drug;Pediatric;Pulmonary Hypertension;Rare Diseases

ORG_DEPT: VETERINARY SCIENCES

PHR: PROJECT NARRATIVE Pulmonary Arterial Hypertension (PAH) contributes to high morbidity and death in children with different types of heart, lung or systemic diseases. Despite advances in the development of PAH-targeted drug therapies in adults, there have been very few studies in children regarding safety, effectiveness and the optimal strategies for using these drugs in infants and children with PAH. Using a highly interactive and well-established network of experienced pulmonary hypertension specialists at multiple academic sites, we propose to determine whether early treatment with a combination of medicines will cause greater and more sustained clinical improvement in children with PAH when compared with monotherapy with sildenafil alone.

PI_NAMEs: ABMAN, STEVEN HERBERT;BERMAN-ROSENZWEIG, ERIKA S.;ROMER, LEWIS H (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: actigraphy;active method;Address;Adult;Age;Assessment tool;biobank;bosentan;Brain Injuries;Caring;Case Series;Cessation of life;Child;Child Care;Childhood;Classification;Clinical;clinical care;clinical practice;Clinical Research;Clinical Trials;Collaborations;Combination Drug Therapy;Combined Modality Therapy;comparative efficacy;Control Groups;Data;Data Coordinating Center;Decision Making;Development;Diagnosis;Disease;Disease Marker;Disease Progression;Drug usage;Early treatment;Effectiveness;efficacy evaluation;Endothelin Receptor Antagonist;Evaluation;evidence base;Exercise Tolerance;experience;follow-up;functional improvement;functional outcomes;Future;Goals;Heart Diseases;hemodynamics;improved;Infant;inhibitor;innovation;Life;Lung;Lung Diseases;Measures;Medicine;Morbidity - disease rate;mortality;multidisciplinary;Nature;novel;optimal treatments;Oral;Outcome;outcome prediction;Patients;Performance;Pharmacotherapy;Phosphodiesterase Inhibitors;phosphodiesterase V;predictive modeling;prognostic tool;programs;pulmonary arterial hypertension;Pulmonary Heart Disease;Pulmonary Hypertension;Quality of life;Randomized, Controlled Trials;Research;Research Institute;Role;Safety;sildenafil;Site;Specialist;standard of care;study population;success;Surrogate Endpoint;symposium;Systemic disease;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Time;treatment group;treatment strategy;trial comparing;Universities;Validation

PROJECT_TITLE: 1/2 Kids MoD PAH Trial: Mono- vs. Duo-Therapy In Pediatric Pulmonary Arterial Hypertension


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: HACKENSACK

ORG_NAME: HACKENSACK UNIVERSITY MEDICAL CENTER

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The early detection of drug resistance in Candida auris infections is instrumental to the efforts to control and eliminate the disease. Current tools are unable to detect low levels of drug-resistant Candida auris fungi, which limits our ability to study the development of drug resistant Candida auris infections. The goal of this project is to develop and validate a novel design of the polymerase chain reaction for the sensitive and selective amplification of drug-resistant Candida auris species.

PI_NAMEs: CHAUHAN, NEERAJ  (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: acquired drug resistance;Adhesives;Amphotericin B;anti-fungal agents;Antifungal Therapy;Azole resistance;Azoles;Bacteria;Biological;Biological Assay;Blood;Candida;Candida auris;Candida glabrata;Candidiasis;Case Study;Cells;Centers for Disease Control and Prevention (U.S.);Clinical;Country;Data;Death Rate;design;detection assay;Development;diagnostic assay;diagnostic tool;Disease;Disease Outbreaks;DNA;drug development;Drug resistance;drug testing;Early Diagnosis;echinocandin resistance;Environmental Pollution;epidemiology study;Expert Opinion;Failure;Flucytosine;Fungal Drug Resistance;fungus;Genes;Genetic;genomic locus;global health;Goals;health care settings;Hospitals;Impairment;Infection;insight;Intermediate resistance;Kidney;Knowledge acquisition;Methodology;Methods;Minimum Inhibitory Concentration measurement;Molecular;Morbidity - disease rate;mortality;Multi-Drug Resistance;Multiple Fungal Drug Resistance;Mus;mutant;Mutation;Mutation Detection;novel;Nursing Homes;older patient;Outcome;pathogenic fungus;Patients;Pharmaceutical Preparations;Phenotype;Polyenes;Polymerase Chain Reaction;Population;Predisposition;prevent;Publishing;Relapse;Reporting;Resistance;resistance in Candida auris;Resistant candida;resistant strain;Sampling;Single Nucleotide Polymorphism;Skin;Standardization;Surface;Testing;Therapeutic;tool;trait;transmission process;Treatment Protocols;Urine;Vertebral column;Virulence;Work;Yeasts

PROJECT_TITLE: Identifying drug-resistant Candida species using SuperSelective primer PCR

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Orphan Drug;Patient Safety;Prevention;Rare Diseases;Tuberculosis;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: BETHESDA

ORG_NAME: HENRY M. JACKSON FDN FOR THE ADV MIL/MED

PHR: Project Narrative Reducing the toll of AIDS and other infectious diseases has been a goal of U.S. National Security Strategy since 2002. TB is a leading cause of mortality globally, particularly in HIV infected populations. Despite progress in blunting the epidemics through broad access to treatment and PrEP, eradication will require clinical research leading to an effective HIV vaccine and treatments that cure or limit disease progression.

PI_NAMEs: AKE, JULIE A.;ROBB, MERLIN L (contact)

PROGRAM_OFFICER_NAME: ROBY, GREGG A,

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Active Immunization;acute infection;Address;Adjuvant;Adult;Africa;AIDS clinical trial group;AIDS prevention;AIDS Vaccines;animal data;Area;Asia;Cell Cycle;Clinical;Clinical Protocols;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Cooperative Group;Clinical Trials Network;Clinical Trials Unit;Cohort Studies;Collaborations;Communicable Diseases;comorbidity;cost effective;Data;Department of Defense;Development;Disease Progression;efficacy trial;Epidemic;experience;Foundations;Funding;Goals;Group Affiliation;Health Services Accessibility;Hepatitis;HIV;HIV Infections;HIV prevention trials network;HIV vaccine;HIV Vaccine Trials Network;HIV/AIDS;HIV/TB;human data;Immunity;innovation;insight;International;Intervention;Kenya;Leadership;Maryland;Military Medicine;Military Personnel;mortality;Mozambique;National Security;novel;Passive Immunization;Phase;phase 1 study;Phase I Clinical Trials;Population;pre-exposure prophylaxis;Prevention;prevention clinical trial;Prevention Research;Prevention trial;programs;Protein Subunits;Research;Research Infrastructure;Research Institute;response;Role;Safety;Sampling;Sampling Studies;Science;Site;Structure;Subunit Vaccines;support network;Tanzania;Technology;Therapeutic;Therapeutic Clinical Trial;Therapeutic Studies;Tuberculosis;tuberculosis treatment;Tuberculosis Vaccines;U-Series Cooperative Agreements;United States;Vaccine Research;vaccine trial;Vaccines;vector

PROJECT_TITLE: The Military HIV Research Program (MHRP) Clinical Trial Unit


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Genetics;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE The highly branched structures of dendrites enable the extraordinary connectivity and information- processing power of the nervous system. The overall goal of this application is to develop multi- scale data-driven models that predict quantitatively how the growth of dendritic tips during development gives rise to the morphology of mature dendrites. Bridging genotype to phenotype is expected to provide insight into the pathophysiology of genetic disorders that affect neuronal structures.

PI_NAMEs: HOWARD, JONATHON  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Affect;Binding;Biological;Birth;cell type;Cells;Cessation of life;Cytoskeletal Proteins;Data;data-driven model;Dendrites;Development;Differential Equation;Dimensions;Disease;dopaminergic neuron;Drosophila genus;Etiology;experimental study;fly;Fractals;Functional disorder;Genetic;Genetic Diseases;genetic manipulation;Genotype;Goals;Growth;Image;information processing;insight;kinetic model;Kinetics;Lead;Length;live cell imaging;Markov Chains;mathematical model;Measurement;Measures;Microtubule-Associated Proteins;Modeling;Molecular;Morphogenesis;Morphology;Motor;multi-scale modeling;multiscale data;Mutation;Nervous System;Neurologic;Neurons;novel;Outcome;Output;Phenotype;Positioning Attribute;predictive modeling;Process;Reporting;Research;Resolution;Shapes;simulation;Structure;temporal measurement;Testing;theories;Time;tool

PROJECT_TITLE: Dendrite structure: Data-Driven Models to Bridge from Molecules to Morphology

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN-M]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Transformation of astrocytes into reactive states is recognized as one of the major hallmarks of neurodegenerative disease including prion, Alzheimer’s, and Parkinson’s diseases. However, very little is known about the role of reactive astrocytes in pathogenesis of prion disease. The current project is designed to fill this gap and is the first to critically examine the role of reactive astrocytes in prion diseases.

PI_NAMEs: BASKAKOV, ILIA V (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Acute;Address;Agreement;Alzheimer's Disease;Animal Model;Animal Testing;Animals;Astrocytes;Biological Assay;blood-brain barrier permeabilization;Brain region;Cell Nucleus;Cells;Chronic;Clinical;conditional knockout;design;Development;Disease;Disease Outcome;Disease Progression;Endothelial Cells;Exhibits;Family;Genetic Transcription;Heterogeneity;improved;Incubated;Infection;Knock-out;Knowledge;Learning;Maintenance;Measures;Microglia;Morphology;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;neuron loss;Neurons;novel;Parkinson Disease;Pathogenesis;Pathway interactions;Phagocytes;Phenotype;Physiological;pre-clinical;Prion Diseases;Prions;response;Role;Synapses;Testing;Therapeutic;Time;transcription factor;transcriptome sequencing;Tropism;Vertebral column;Work

PROJECT_TITLE: Role of reactive astrocytes in prion diseases

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Chronic Fatigue Syndrome (ME/CFS);Clinical Research;Infectious Diseases;Neurosciences;Pediatric

ORG_CITY: CHICAGO

ORG_DEPT: MISCELLANEOUS

ORG_NAME: DE PAUL UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative Our proposed study will allow us to uncover maintenance factors for ME/CFS in college age students who developed IM at Wave 1 as well as the incidence of and risk factors for ME/CFS for those who did not develop ME/CFS at Wave 1.

PI_NAMEs: JASON, LEONARD A (contact);KATZ, BEN Z.

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Acute;Adolescent;Age;Applications Grants;Biological;Blood;Blood specimen;Chronic Fatigue Syndrome;Climacteric;Clinical;cohort;college;Common Data Element;Coping Skills;Data;Data Set;Development;Diagnosis;Disease;Employment Status;Enrollment;epidemiology study;Evolution;experience;follow-up;Funding;Grant;Health;Human Herpesvirus 4;Incidence;Infectious Mononucleosis;Interview;longitudinal design;Maintenance;mental state;National Institute of Neurological Disorders and Stroke;Natural History;Participant;Patients;Perception;Predisposing Factor;prospective;Prospective Studies;psychologic;Research Proposals;Risk Factors;Sampling;Series;Students;Support System;Symptoms;Systemic infection;Time;United States National Institutes of Health;university student;Well in self;Work;young adult;Youth

PROJECT_TITLE: Maintenance and Incidence of ME/CFS following Mono

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CFS-N(80)S]


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Emphysema;Genetics;Lung;Tobacco;Tobacco Smoke and Health

PHR: PROJECT NARRATIVE This project investigates the mechanisms by which the innate immune protein Macrophage Migration Inhibitory Factor (MIF) protects against emphysema. In this proposal we will investigate the role of the MIF receptor CD74 and the downstream consequence of cellular senescence as key targets for MIF to mediate its protective effect. Successful completion of these studies may uncover novel therapeutic targets to treat emphysema.

PI_NAMEs: SAULER, MAOR  (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Address;Agonist;Alleles;Apoptosis;Attenuated;Biology;Cause of Death;Cell Aging;cell type;Cells;Chronic;Chronic Obstructive Pulmonary Disease;cigarette smoke;cigarette smoke-induced;Cigarette smoke-induced emphysema;cytokine;Cytoprotection;Data;Development;Disease;Disease Progression;DNA Damage;effective therapy;Endothelial Cells;Endothelium;exposure to cigarette smoke;Flow Cytometry;gain of function;Genetic;Genetic Polymorphism;Genetic study;Goals;Histology;Homeostasis;Human;Image;Immune;improved;loss of function;LoxP-flanked allele;Lung;Lung Diseases;Macrophage;MAPK3 gene;Mediating;Methods;migration;Migration Inhibitory Factor;modifiable risk;Molecular;mouse model;Mouse Strains;Mus;new therapeutic target;novel;oxidative DNA damage;Oxidative Stress;Oxidative Stress Induction;Pathogenesis;Pathologic;Pathway interactions;Patients;pharmacologic;Predisposition;promoter;protective effect;Proteins;Pulmonary Emphysema;receptor;Reporter;Research Personnel;resilience;response;Risk Factors;Role;senescence;senescent cell;Severities;Severity of illness;Signal Pathway;Signal Transduction;Slice;small molecule;Smoker;stress reduction;Study models;Testing;Therapeutic;Tissues;Translating;Treatment Efficacy;United States;Visualization;Work;X-Ray Computed Tomography

PROJECT_TITLE: Role of MIF and CD74 in the pathogenesis of emphysema

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Hepatitis - B;Immunization;Infectious Diseases;Liver Disease;Orphan Drug;Pediatric;Prevention;Rare Diseases;Tuberculosis;Vaccine Related;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative The NIH established collaborative HIV/AIDS Clinical Trials Networks to advance the science of HIV prevention and treatment and to contribute to the end of the HIV epidemic. The UNC Global HIV Treatment and Prevention Clinical Trials Unit will contribute to the work of all four NIH HIV Clinical Trials Networks by enrolling those populations most affected by HIV and by providing innovate scientific leadership and by contributing to the leadership of the networks.

PI_NAMEs: ERON, JOSEPH J (contact);HOSSEINIPOUR, MINA CHRISTINE;WOHL, DAVID A

PROGRAM_OFFICER_NAME: GUBB, STEPHANIE MAJER

PROJECT_TERMS: acute infection;Adherence;Adolescent;adolescent woman;Adult;Affect;Africa;African;AIDS prevention;antiretroviral therapy;Area;black women;Caring;Cells;Child;Childhood;Clinical;Clinical Investigator;Clinical Research;clinical research site;Clinical Treatment;Clinical Trials;Clinical Trials Network;Clinical Trials Support Unit;Clinical Trials Unit;co-infection;Collaborations;Communication;Communities;community engagement;comorbidity;Complex;data management;Dedications;Development;Disease remission;Doctor of Philosophy;Drug Kinetics;Drug resistance in tuberculosis;early phase trial;Enrollment;Epidemic;experience;Female Adolescents;follow-up;gender diversity;Goals;Hepatitis B;Hepatitis B Virus;high risk;high risk population;HIV;HIV Antibodies;HIV drug resistance;HIV vaccine;HIV/AIDS;HIV/TB;Incidence;Individual;Infant;Injecting drug user;innovation;International;Intervention;Investigation;Laboratories;Lead;Leadership;Malawi;men of color;men who have sex with men;Mind;Mother-to-child HIV transmission;National Institute of Allergy and Infectious Disease;Newly Diagnosed;North Carolina;novel;Nucleosides;organizational structure;Participant;participant retention;pathogen;Patient Recruitments;Persons;Pharmaceutical Preparations;Pharmacy facility;Phase;phase 3 study;Population;Populations at Risk;Positioning Attribute;pre-exposure prophylaxis;pregnant;Pregnant Women;Prevention;prevention clinical trial;Prevention trial;Principal Investigator;Public Health;Race;Recording of previous events;recruit;Research;Research Personnel;Risk;Sampling;Science;Scientist;Senior Scientist;skills;Southeastern Asia;Southern Africa;Talents;Testing;Therapeutic;Therapeutic Clinical Trial;transgender women;translational scientist;treatment as prevention;treatment trial;Tuberculosis;Tuberculosis Vaccines;United States National Institutes of Health;Universities;Vaccine Clinical Trial;vaccine trial;Vaccines;Vietnam;viral rebound;virtual;Virus;Virus Activation;volunteer;Work;young man;young men who have sex with men;young woman

PROJECT_TITLE: University of North Carolina Global HIV Prevention and Treatment Clinical Trials Unit


NIH_SPENDING_CATS: Lung;Pulmonary Fibrosis;Rare Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Idiopathic Pulmonary Fibrosis (IPF) is a fatal lung disease characterized by progressive scarring of the lungs. We have recent evidence that matrix stiffness gradients produced in fibrotic lungs promote progressive recruitment of fibroblasts to sites of active fibrosis via durotaxis – the directed migration of cells from regions of lower to higher stiffness. The studies proposed in this application are designed to visualize fibroblast durotaxis in vivo, to define the molecular mechanisms of fibroblast durotaxis and to develop novel therapeutic strategies to inhibit durotaxis in patients with IPF, an incurable and deadly disease.

PI_NAMEs: MEDOFF, BENJAMIN DAVID (contact)

PROJECT_TERMS: Acetylation;Acetyltransferase;Actins;Active Sites;Adhesions;Affect;antifibrotic treatment;Area;Atomic Force Microscopy;Automobile Driving;Binding;Biochemical;Biophysics;Breathing;cell motility;cell type;Cells;chemokine;chemokine receptor;Chemotactic Factors;Chemotaxis;Cicatrix;Clathrin-Coated Vesicles;Clinical Treatment;Clinical Trials;Complex;Cues;Data;design;Development;Disease;Engineering;Enzymes;experimental study;falls;Feedback;Fibroblasts;Fibrosis;fibrotic lung;Human;human disease;Hydrogels;idiopathic pulmonary fibrosis;Image;Immune;improved;In Vitro;in vivo;indium-bleomycin;inhibitor;Integrin alphaVbeta3;Integrins;Knockout Mice;Knowledge;Laboratories;Leukocyte Trafficking;Lung;lung development;Lung Diseases;lung injury;Maps;Measures;Mechanics;Mediating;Mediator;Methods;Microtubules;Modeling;Molecular;mouse model;multiphoton microscopy;Mus;Myofibroblast;new therapeutic target;novel;novel therapeutic intervention;Pathogenesis;Pathologic;Pathway interactions;Patients;Pattern;paxillin;Process;PTK2 gene;Pulmonary Fibrosis;recruit;Recycling;response;Role;Signal Transduction;Site;Slice;small molecule inhibitor;Spatial Distribution;Structure of parenchyma of lung;Testing;Therapeutic;tissue injury;Tissues;Treatment Efficacy;Tubulin;Variant;Visualization

PROJECT_TITLE: Targeting durotaxis in lung injury and fibrosis


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: The US spends more than $635 billion per year on chronic pain, however, the currently available drugs are not effective and often lead to dependence. Neurobiological, genetic, and preclinical studies have suggested that inhibitors of adenylyl cyclase type I (AC1) offer an alternative target. We propose that the development and characterization of small molecule inhibitors of AC1 as probes will allow us to evaluate and validate AC1 as a new drug target.

PI_NAMEs: FLAHERTY, DANIEL PATRICK (contact);WATTS, VAL J

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Acute;addiction;Adenylate Cyclase;adenylyl cyclase 1;analog;Animal Model;aqueous;Behavioral Assay;Biological Assay;Biological Availability;Chemicals;Chronic inflammatory pain;chronic pain;chronic pain management;chronic painful condition;clinical development;Collection;Communities;conditioned place preference;cost;Cyclic AMP;Dependence;design;Development;Drug Industry;Drug Kinetics;Drug Targeting;Drug usage;Evaluation;Exhibits;Freund's Adjuvant;G-Protein-Coupled Receptors;Genetic;Genetic study;Goals;Health;Hyperactivity;improved;In Vitro;in vitro Model;in vivo;Inflammatory;inflammatory pain;inhibitor;knockout animal;Knockout Mice;Lead;lead optimization;Literature;Mediating;Molecular Probes;mouse model;Mus;nanomolar;Neurobiology;Neurologic;Neuronal Plasticity;Neurons;Neuropathy;New Agents;new therapeutic target;novel;Opiate Addiction;Opioid;opioid withdrawal;Pain;pain processing;painful neuropathy;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology;pre-clinical;preclinical study;prevent;Production;Property;Protein Isoforms;Pyrimidinones;Rattus;Reporting;Research;Research Personnel;response;Rewards;Risk;scaffold;screening;Series;side effect;small molecule inhibitor;small molecule libraries;Solubility;Specificity;Structure-Activity Relationship;Testing;Therapeutic;Time;Tissues;tool;Toxic effect;Validation;War;Withdrawal

PROJECT_TITLE: Pharmacological validation of adenylyl cyclase 1 as a drug target for chronic pain

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

ORG_CITY: ROCHESTER

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Mitochondria are important for stroke survival and can contribute to either adaptation or energetic failure through mechanisms that remain incompletely understood. We propose a novel approach that employs light to directly regulate mitochondrial function to determine when, where, and how it alters the balance between damage and protection during ischemic stroke. We anticipate that this approach will allow us to better understand how mitochondrial function regulates stroke outcomes.

PI_NAMEs: WOJTOVICH, ANDREW PHILLIP (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Address;Adult;Affect;Animal Behavior;Animal Model;Axon;Behavioral;Bioenergetics;biological adaptation to stress;Biological Models;Biosensor;Caenorhabditis elegans;Calcium;Cations;Cell Culture Techniques;Cell Death;Cell membrane;Cell Physiology;cell type;Cells;Communication;CRISPR/Cas technology;Development;Dissociation;Distant;Energy Supply;Equilibrium;Etiology;Event;Exhibits;Failure;Future;Gene Expression;Genes;Genetic;genetic approach;Genetic Epistasis;Hypoxia;In Vitro;in vivo;Inner mitochondrial membrane;insight;Intervention;Ischemia;Ischemic Stroke;Learning;Light;Location;Measures;Mediating;Membrane Potentials;Metabolic;Metabolism;Methods;Mitochondria;mitochondrial membrane;Molecular;Molecular Probes;Morphology;mutant;neuron loss;neuronal cell body;neuronal circuitry;neuronal survival;Neurons;novel;novel strategies;optogenetics;Outcome;Output;Oxygen;Oxygen Consumption;Pathologic;Pathology;Pathway interactions;pharmacologic;Production;promoter;Proteins;Proton Pump;Protons;Reactive Oxygen Species;Recovery;Reperfusion Injury;Reperfusion Therapy;Reporter;response;Role;Severities;Signal Pathway;Signal Transduction;Specificity;Stress;Stroke;stroke outcome;Surveys;System;Techniques;Testing;Therapeutic;Time;Tissues;tool;Whole Organism

PROJECT_TITLE: Mitochondrial Energy Sensing and Neuronal Ischemia

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Atherosclerosis

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: This application focuses on the molecular processes required for movement of lipids from the circulation into parenchymal cells. We propose to study how the fatty acid transporter CD36 mediates the transfer of fatty acids into and across endothelial cells, and how endothelial cells through CD36 and other receptors internalize and metabolize lipoprotein lipids.

PI_NAMEs: ABUMRAD, NADA A.;GOLDBERG, IRA J (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Adipose tissue;Affect;Albumins;Alkynes;Animal Model;Apolipoproteins B;Apoproteins;Atherosclerosis;Biochemistry;Biogenesis;Biology;Calories;Capillary Permeability;caveolin 1;Cell Physiology;Cell secretion;Cell surface;Cells;Cellular biology;Cholesterol;Cholesterol Esters;Chylomicrons;Circulation;Collaborations;Complex;Confocal Microscopy;Data;Development;Disease;Electron Microscopy;Endothelial Cells;Endothelium;Esters;Event;exosome;extracellular vesicles;Fasting;fatty acid metabolism;fatty acid transport;Fatty Acids;Foam Cells;Funding;Gene Expression;gene function;Genes;Grant;Heart;Heart failure;Human;In Vitro;in vivo;Insulin Receptor;Intake;Intercellular Junctions;Investigation;Knock-out;Knockout Mice;Laboratories;Lipase;Lipids;Lipolysis;lipoprotein lipase;Lipoproteins;long chain fatty acid;LoxP-flanked allele;Macrophage;Mediating;Metabolic;Metabolic syndrome;Metabolism;Molecular;Movement;Mus;Muscle;Muscle Cells;nanoGold;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;novel;Obesity;operation;Organ;Particle Size;Pathologic;Pathway interactions;Phospholipids;Physiological;Population;prevent;Process;Proteins;receptor;receptor internalization;Receptor Signaling;Regulation;Reporter;Reporting;Retinoids;Role;skeletal tissue;Source;SR-BI receptor;src-Family Kinases;synergism;Testing;Tissues;transcytosis;Triglycerides;uptake;Very low density lipoprotein;very low density lipoprotein triglyceride;Vesicle;Visualization

PROJECT_TITLE: Pathways of Tissue Lipid Uptake

STUDY_SECTION: INMP

STUDY_SECTION_NAME: Integrative Nutrition and Metabolic Processes Study Section[INMP]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Patient Safety;Racial and Ethnic Minority Health Research;Schizophrenia;Serious Mental Illness;Social Determinants of Health

ORG_DEPT: ADMINISTRATION

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative We will translate novel statistical approaches to extract scientifically robust and valid causal evidence of the effectiveness and safety outcomes of antipsychotic drugs used by elderly adults with schizophrenia by exploiting large, observational, longitudinal databases. Our proposal has high public health relevance because (1) we focus on elderly adults with an illness associated with a heavy disease burden for which antipsychotic drug treatments are a critical treatment component, yet drug outcomes for this growing population are poorly understood; (2) we assess the extent to which patient race/ethnicity and social contextual factors known to influence health behaviors may moderate drug outcomes; (3) we characterize the risk and benefits of drug regimens, thus providing valuable information to optimize outcomes of long and complex exposures typical of usual care settings; and (4) we apply generalizable approaches to target parameters of scientific interest for other chronic illness populations.

PI_NAMEs: HORVITZ-LENNON, MARCELA V;NORMAND, SHARON-LISE TERESA (contact)

PROGRAM_OFFICER_NAME: EVANS, JOVIER D

PROJECT_TERMS: Acute;Adherence;Adult;adverse outcome;Affect;Age;age group;aged;Antipsychotic Agents;Area;beneficiary;Benefits and Risks;burden of illness;Caring;Chronic;Chronic Disease;Clinical;Clinical Trials;Cognition Disorders;cohort;common treatment;comorbidity;Complex;contextual factors;cost;Crime;Data;Databases;Dependence;Diagnosis;disability payment;disability-adjusted life years;disparity reduction;Dose;Drug Prescriptions;Drug usage;Economics;Effectiveness;effectiveness outcome;efficacy trial;Elderly;Environment;Equilibrium;ethnic diversity;ethnic minority population;Ethnic Origin;Ethnic Population;Exposure to;Face;Financial cost;Geography;Health behavior;health care availability;Heterogeneity;high dimensionality;Household;human old age (65+);improved;Income;indexing;Individual;Insurance Carriers;interest;Interruption;late life;Learning;Link;longitudinal database;longitudinal dataset;Low income;Machine Learning;Maintenance;Medical;Medicare;Medicare/Medicaid;medication compliance;Methods;Modeling;National Institute of Mental Health;novel;older patient;Outcome;Outcome Assessment;outcome disparities;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phase;Population;Prevalence;Probability;public health relevance;Race;racial difference;racial diversity;racial minority population;racial population;randomized trial;Regimen;Research Personnel;Risk;Role;Safety;safety outcomes;Schizophrenia;semiparametric;social;social disparities;Social Environment;social health determinants;Statistical Methods;Strategic Planning;Subgroup;Time;Translating;treatment adherence;treatment as usual;treatment comparison;treatment disparity;treatment effect;Treatment Effectiveness;Treatment outcome;treatment pattern;Treatment Protocols;treatment risk;Trees;Variant;Vulnerable Populations;Work

PROJECT_TITLE: Robust Learning Approaches for Assessing Effects and Effect Heterogeneity of Real World Antipsychotic Treatment Regimes in Elderly Persons with Schizophrenia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-G(90)S]


NIH_SPENDING_CATS: Bioengineering;Chronic Obstructive Pulmonary Disease;Clinical Research;Data Science;Health Services;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention

ORG_CITY: HANOVER

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative The proposed program in chronic obstructive pulmonary disease (COPD) will provide actionable tools and information from health care data and machine learning to identify early and prevent COPD disease progression and major adverse health care encounters. The risk tools will be used in every day out-patient health care practice to help prevent disease progression requiring home oxygen use, major adverse health care encounters, and improve health care delivery for patients living with COPD in the community.

PI_NAMEs: BROWN, JEREMIAH R (contact);DAVIS, SHARON ELIZABETH;MATHENY, MICHAEL E.

PROGRAM_OFFICER_NAME: STEFAN, MIHAELA STEFANIA

PROJECT_TERMS: Acceleration;Acute;Adoption;Adverse event;Ambulatory Care;Automated Annotation;biomedical informatics;Calibration;Caregivers;Caring;Chronic;Chronic Obstructive Pulmonary Disease;Clinic;Clinical;clinical application;clinical care;clinical implementation;Code;Communities;Consumption;Controlled Vocabulary;cost;Data;data streams;data visualization;deep learning;deep learning algorithm;deep learning model;Detection;Development;Diagnosis;Dimensions;discrete data;Disease;Disease Progression;Early identification;Electronic Health Record;end stage disease;Event;Financial Hardship;functional status;Future;Health;health care delivery;health care service utilization;Health Personnel;Health Policy;Health system;Healthcare;Healthcare Systems;high risk;Home;hospital readmission;Hospitalization;Human;improved;Individual;Ingestion;Machine Learning;machine learning method;Maintenance;Manuals;Maps;Medical;Methods;Modeling;National Heart, Lung, and Blood Institute;Natural Language Processing;Nature;Outcome;Outpatients;Oxygen;Oxygen Therapy Care;Patient Care;Patient Care Management;Patients;Performance;Persons;Physicians;predictive modeling;predictive tools;prevent;Procedures;Process;programs;prospective;Provider;readmission risk;Recording of previous events;Research;Resources;Risk;Risk Factors;social;Structure;structured data;support tools;Symptoms;System;Techniques;Text;Time;tool;unstructured data;Update;usability;user centered design;Validation;Visit;Visualization;web site

PROJECT_TITLE: DeepCOPD: Development and Implementation of Deep Learning to Predict and Prevent COPD Health Care Encounters

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: HD

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: HADLEY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: The proposed project is relevant to public health because it will identify the sperm factors that induce the Ca2+ release required for egg activation and initiation of development in mammals. Approximately a third of all cases of human infertility is associated with a male condition, and the molecules studied here underlie male infertility, and identifying their function will improve the treatment of infertile patients. Thus, the proposed research is relevant to the part of the NIH’s mission that pertains to developing fundamental knowledge that will enhance health and reduce the burden of disease.

PI_NAMEs: FISSORE, RAFAEL ANTONIO (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Affect;Animals;Antibodies;blastocyst;burden of illness;Calcium;Calcium Oscillations;Calcium Signaling;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Contraceptive methods;Data;Defect;Development;Diagnosis;Diagnostic;diagnostic value;egg;embryo culture;Embryonic Development;Embryonic Induction;Enzymes;Event;Failure;Fertility;Fertilization;Fertilization failure;Functional disorder;Genetic;Germ Cells;Goals;Health;Hour;Human;human male;Immunofluorescence Immunologic;improved;Infertility;innovation;inorganic phosphate;Inositol;Investigation;Knockout Mice;Knowledge;Laboratories;male;male fertility;Male Infertility;Mammals;Mediating;Messenger RNA;Methods;Mission;Modeling;Modification;Molecular;Monitor;Mus;Mutation;novel;Outcome;Patients;Pattern;Periodicals;Phosphoinositide Pathway;Phospholipase;Phospholipase C;Physiological;Plants;prevent;Production;programs;Protein Isoforms;Public Health;receptor;Regulation;reproductive;Research;Residual state;response;Role;Signal Transduction;Site;spatiotemporal;sperm cell;System;Techniques;Testing;Therapeutic;United States National Institutes of Health;zygote

PROJECT_TITLE: Mammalian Fertilization: Identifying the second sperm factor that induces residual calcium oscillations and its contributions to egg activation

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Autoimmune Disease;Lupus;Scleroderma

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PHR: Narrative The presence of autoantibodies in the blood are an important indicator of autoimmune diseases, including those associated with exposure to toxic materials like mercury. An animal model of mercury-induced autoimmune disease will be used to determine the early steps in autoantibody production. These studies will lead to a greater understanding of the development of autoimmune disease.

PI_NAMEs: POLLARD, KENNETH MICHAEL (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: adaptive immunity;Affect;Animal Model;Antibody Formation;Antigen Receptors;Appearance;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;autoreactive B cell;B cell repertoire;B-Cell Antigen Receptor;B-Lymphocytes;Biological Models;Blood;Bone Marrow;CD4 Positive T Lymphocytes;Characteristics;Chronic;clinical diagnosis;DBA/2 Mouse;Development;Diagnosis;Disease;draining lymph node;Early identification;Epitopes;Event;Excision;Experimental Animal Model;experimental study;Exposure to;fibrillarin;Genes;Genetic;genetic element;Human;human disease;human model;Hypertrophy;Immune response;Immune Tolerance;Immunologics;Inflammation;inflammatory marker;Inflammatory Response;insight;Interferon Type II;Interleukin-6;Kidney;Knowledge;Link;Lymphoid;Mercuric chloride;Mercury;Modeling;Molecular;Mus;Natural Immunity;Nuclear Antigens;Nucleic Acids;Nucleolar Proteins;Outcome;Pathogenicity;Pathologic;Pathology;Patients;Pattern;Peptide Initiation Factors;Production;Resistance;response;RNA;Scleroderma;secondary lymphoid organ;Serology;Severity of illness;Silicon Dioxide;Site;Spleen;Sterility;Structure of germinal center of lymph node;Study models;subcutaneous;systemic autoimmune disease;Systemic Lupus Erythematosus;T-Lymphocyte;Tissues;urinary;Xenobiotics

PROJECT_TITLE: Early Pathogenic Steps in Xenobiotic-Induced Autoimmunity

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Physical Activity;Prevention

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Developing more effective prevention strategies for Alzheimer’s disease and related dementias (ADRD) will require more precision-based approaches in terms of identifying who will benefit the most and when. Understanding whether physical activity across the adult life course (e.g., early adult life, midlife, and late-life) contributes similarly or differentially to cognitive resilience will inform more effective prevention strategies for ADRD, based on knowing when modifiable lifestyle interventions will be most beneficial. In addition, identifying predictors of cognitive resilience associated with specific measures of physical activity across the adult life course will help to guide more precision-based participant selection strategies for future clinical trials and interventional studies for the primary prevention of ADRD.

PI_NAMEs: HWANG, PHILLIP  (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Address;Adult;Aging;aging brain;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid beta-42;Apolipoprotein E;Atrophic;Attention;Behavioral;Boston;Brain;brain health;brain volume;career;cerebral atrophy;Characteristics;Classification;Clinical;Clinical Trials;Clinical Trials Design;Cognition;Cognitive;cognitive function;cognitive testing;Collection;Compensation;coping;critical period;Data;Dementia;dementia risk;design;Development;digital technology;Dimensions;Disease;Doctor of Philosophy;emerging adult;Environment;Evaluation;executive function;Family history of;Fostering;Framingham Heart Study;Frequencies;Future;Generations;Genetic Carriers;Goals;high dimensionality;high risk;Hippocampus;Household;human old age (65+);Impaired cognition;indexing;Individual;Interdisciplinary Study;Intervention;Intervention Studies;Investigation;Knowledge;late life;Lead;Leisures;Life;Life Cycle Stages;life span;lifestyle data;lifestyle intervention;Logistic Regressions;Longitudinal cohort study;machine learning algorithm;machine learning method;Magnetic Resonance Imaging;Measurement;Measures;medical schools;Memory;Mentorship;middle age;modifiable lifestyle factors;Nerve Degeneration;neural;Neurocognitive;Neuroepidemiology;neuroimaging;neuromechanism;neuropathology;Neuropsychological Tests;Neuropsychology;observational cohort study;Occupational;older adult;Participant;participant enrollment;Physical activity;Physical Stimulation;Plasma;policy implication;predictive modeling;prevent;Prevention Research;Prevention strategy;preventive intervention;Primary Prevention;Process;promote resilience;psychologic;Questionnaires;random forest;Recommendation;Recreation;Research;Research Personnel;Residual state;resilience;resilience factor;Risk;Risk Factors;risk stratification;Role;Sports;statistical learning;supervised learning;support vector machine;technology platform;Thinness;Time;Training;United States;Universities;wearable data;wearable device;Work

PROJECT_TITLE: Physical activity over the adult life course and cognitive resilience to Alzheimer's disease and related dementias

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Congenital Structural Anomalies;Genetics;Infant Mortality;Lung;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases;Sleep Research;Sudden Infant Death Syndrome

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE The failure of protective neonate respiratory reflexes including the hypercapnic, hypoxic, and auto-resuscitation reflexes are hypothesized to be perturbed in Sudden Infant Death Syndrome and other congenital respiratory disorders. The proposed studies aim to carry out a genetic screen utilizing KOMP-2 mutant mouse strains to uncover genes critical to neonate protective respiratory reflexes and inform upon genetic, molecular, and cellular processes that underly the development and function of neonate respiratory neural networks that may be perturbed in respiratory pathophysiologies.

PI_NAMEs: RAY, RUSSELL S (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: 1 year old;Adult;Air;Anoxia;Apnea;automated assessment;Bradycardia;brain abnormalities;Brain Stem;Breathing;Carbon Dioxide;causal variant;Cause of Death;Cell Physiology;Cessation of life;Characteristics;college;Computer software;congenital central hypoventilation syndrome;congenital respiratory disorder;Data;Data Analyses;data analysis pipeline;Development;developmental disease;Diagnostic;DNA Sequence Alteration;Embryo;Etiology;Exposure to;Failure;feature detection;Foundations;Functional disorder;Gases;Gene Expression;Genes;Genetic;Genetic Markers;Genetic Screening;Goals;Heart Rate;Heterozygote;Homeostasis;Human;Hypoxia;Imaging Techniques;In Situ Hybridization;in vivo;Infant;innovation;International;Joubert syndrome;knock out mouse project;Knock-out;Laboratories;Link;loss of function mutation;Measurement;Medicine;Modeling;Molecular;molecular marker;mouse genome;Mus;mutant;Mutant Strains Mice;Mutate;Mutation;Neonatal Mortality;neonate;Nervous System;neural network;Neuroanatomy;Neurologic;Neurophysiology - biologic function;novel;Outcome;Pattern;Perinatal;Perinatal mortality demographics;Phenotype;Physiological;Pitt-Hopkins syndrome;Positioning Attribute;Production;prophylactic;Reflex action;Respiration;Respiration Disorders;respiratory;respiratory hypoxia;Respiratory physiology;respiratory reflex;Resuscitation;Rett Syndrome;Robotics;screening;Sensory;Series;stem;Sudden infant death syndrome;Syndrome;System;Therapeutic;transcriptome sequencing

PROJECT_TITLE: An in vivo screen for genes underlying protective neonate respiratory reflexes to identify potential contributors to Sudden Infant Death Syndrome and other congenital respiratory pathophysiologies


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences;Sleep Research

ORG_DEPT: BIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative Daily rhythms in rest-activity are well-known, but it is unknown how they arise or synchronize to local time. Our preliminary data show that circadian rhythms intrinsic to motor cortex can be entrained in vivo and in vitro. We will test the roles of specific cells and molecules in producing daily rhythms in cortical neurons and astrocytes and in a variety of behaviors.

PI_NAMEs: HERZOG, ERIK  (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Ablation;Alzheimer's Disease;Area;Astrocytes;Behavior;Behavioral;Brain;Brain region;Calcium;cell type;Cells;circadian;circadian biology;circadian pacemaker;circadian regulation;Circadian Rhythms;Color;Corticosterone;Darkness;Data;Disease;drinking;Eating;experimental study;Food;Foundations;Gene Expression;Genes;genetic manipulation;Glucocorticoid Receptor;Glucocorticoids;Grooming;hippocampal pyramidal neuron;Hormone secretion;Hypothalamic structure;In Vitro;in vivo;Light;Link;Literature;Liver;Locomotion;Machine Learning;Mammals;Mate Selections;Methods;Modeling;Motor;Motor Activity;motor behavior;Motor Cortex;Mus;Neocortex;Neuroglia;Neurons;olfactory bulb;Output;Pacemakers;Pancreas;Pattern;Periodicity;Peripheral;Phase;Physiology;Prevalence;Property;real-time images;receptor expression;Regulation;Research Personnel;Rest;Retina;Role;Schedule;Schizophrenia;Signal Transduction;Skeletal Muscle;Sleep;Smell Perception;suprachiasmatic nucleus;System;Techniques;Testing;Time;Tissues;tool

PROJECT_TITLE: Circadian regulation of neocortex

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ORG_CITY: IOWA CITY

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Sudden unexpected death in epilepsy (SUDEP) is the most common cause of death in patients with chronic refractory epilepsy, and there are no known preventive strategies. Recent studies indicate the inciting event in SUDEP is seizure-induced loss of breathing, which occurs with seizure spread to the amygdala. This proposal will identify neural mechanisms by which the amygdala influences the brain’s respiratory control network during normal breathing, which is critical to designing safe and effective new therapies for sudden unexpected death in epilepsy (SUDEP) and other neurological disorders that affect breathing.

PI_NAMEs: DLOUHY, BRIAN J (contact)

PROJECT_TERMS: Address;Affect;Air;Air Movements;Amygdaloid structure;Anatomy;Animal Model;Apnea;awake;Behavior;Brain;Brain Stem;Breathing;Carbon Dioxide;career;Cause of Death;central pattern generator;Central Sleep Apnea;Cessation of life;Chemoreceptors;Chronic;clinical practice;Collaborations;college;Complement;Cues;Data;design;Development;Disease;Doctor of Medicine;Dyspnea;Electric Stimulation;Electrophysiology (science);Elements;Environment;Epilepsy;Event;experience;experimental study;Functional Magnetic Resonance Imaging;Funding;Goals;Human;human subject;Hunger;Hypercapnia;Impairment;improved;Institution;interest;Intractable Epilepsy;Iowa;Knowledge;Learning;Mediating;Medicine;Mentors;Mentorship;Methods;Nervous System Disorder;neural;Neurobiology;neuromechanism;Neurons;neurophysiology;neuroregulation;Neurosurgeon;neurosurgery;neurotransmission;novel;novel therapeutics;Operative Surgical Procedures;Output;Patients;Perception;Performance;Positioning Attribute;Prevention strategy;programs;Prosencephalon;Research;Respiration;respiration regulation;respiratory;Respiratory physiology;response;Scientist;Seizures;Series;Signal Transduction;Site;skills;Spinal Cord;sudden unexpected death in epilepsy;System;Techniques;Testing;theories;Training;Universities

PROJECT_TITLE: Amygdala modulation of volitional versus automatic breathing

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Sarcopenia

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE This project will define whether central autonomic neurons regulate neuromuscular junction transmission and skeletal muscle structure and function, and their vulnerability to cumulative damage over time accelerates sarcopenia and motor deficits in early Alzheimer’s Disease (AD). This study will define the mechanisms by which impaired central autonomic network regulation of the peripheral SNS leads to skeletal muscle sympathetic and motor denervation, and loss in mass and strength, and will enable detection of predementia AD and formulation of effective treatments for each disease stage.

PI_NAMEs: DELBONO, OSVALDO  (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: 3xTg-AD mouse;Acceleration;Adrenergic Receptor;Age;Alzheimer's Disease;Alzheimer's disease patient;Amyloid;Attenuated;Behavioral;Brain Stem;brain volume;Cells;Central Nervous System;cerebral atrophy;Chronic;clinical diagnosis;Cognition;Cognitive;cognitive function;delivery vehicle;Dementia;Denervation;Deposition;design;designer receptors exclusively activated by designer drugs;Detection;Disease;Disease Progression;Drug Modulation;effective therapy;Formulation;G-Protein-Coupled Receptors;Genetic;Genetic Vectors;Hindlimb;Hyperactivity;hyperphosphorylated tau;Impaired cognition;Impairment;Inflammation;innovation;Intervention;Label;light gated;locus ceruleus structure;Mass Spectrum Analysis;Measures;Mediating;mild cognitive impairment;Molecular;Motor;motor deficit;Motor Neurons;Muscle;muscle form;Muscle function;muscle strength;muscular structure;Musculoskeletal structure;Myopathy;nerve supply;Neurobehavioral Manifestations;Neurofibrillary Tangles;Neuromuscular Junction;neuron loss;Neurons;noradrenergic;Norepinephrine;novel;optogenetics;patch clamp;Pathology;Pathway interactions;Peripheral;Peripheral Nerves;Phenotype;Physical activity;Physical Function;Pontine structure;Predisposition;prevent;Proteomics;Receptor Activation;receptor-mediated signaling;Recombinant adeno-associated virus (rAAV);Regulation;Resolution;retrograde transport;Risk;Role;sarcopenia;senescence;sensor;Signal Transduction;Skeletal Muscle;Spinal Cord;Subgroup;Synapses;tau aggregation;tau Proteins;tau-1;Testing;Thinness;Time;transcriptome sequencing;transcriptomics;transmission process;vector;Viral Vector

PROJECT_TITLE: Accelerated Sarcopenia in Early Alzheimer's Disease

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: PROJECT NARRATIVE PI: Bagaitkar The NADPH oxidase enzyme complex generates reactive oxygen species (ROS) that are essential in anti- microbial defense. A large body of literature now supports a role for NADPH oxidase derived ROS in the modulation of host inflammatory pathways via redox regulation of immune cell effector functions. We aim to elucidate how ROS modulates neutrophil and macrophage responses in the oral mucosa. Insights gained from these studies would enable us to better understand the chronic inflammation in periodontitis.

PI_NAMEs: BAGAITKAR, JUHI  (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Ablation;Acute;Alleles;Alveolar Bone Loss;antimicrobial;Autoimmune Diseases;Cells;Chronic;Chronic Granulomatous Disease;Clinical Research;Communicable Diseases;Complex;conditional knockout;cytokine;Data;Diffusion;Disease;dysbiosis;Effector Cell;Enzymes;Etiology;Family;Functional disorder;Generations;Genes;Genetic;Genetic Transcription;Gingiva;Immune;Immune response;immunodeficiency;immunopathology;immunoregulation;In Vitro;in vivo;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;Inherited;inhibitor;insight;Integration Host Factors;Knockout Mice;leukocyte activation;Leukocytes;Life;Ligature;Literature;Macrophage;Mediating;Multienzyme Complexes;Mus;Mutation;NADPH Oxidase;Nature;neutrophil;novel;Oral;Oral cavity;oral microbiome;Oral mucous membrane structure;Outcome;Oxidants;Oxidases;Oxidation-Reduction;Oxygen;Pathogenesis;Pathway interactions;Periodontal Diseases;Periodontitis;Play;Predisposition;Production;Publishing;Reactive Oxygen Species;recruit;Regulation;Resolution;response;Risk;Role;soft tissue;Source;Superoxides;Systemic disease;Testing;Tissues;Tooth structure;Work

PROJECT_TITLE: Redox Regulation of Gingival Inflammation

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Health Services;Immunization;Infectious Diseases;Influenza;Pediatric;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: PROJECT NARRATIVE Developing and evaluating vaccines for existing and newly emerging pathogens is a priority. This proposal will enhance the ability of the NIH to pursue its mission to conduct and support applied research to better understand, treat, and ultimately prevent infectious diseases.

PI_NAMEs: FRENCK, ROBERT WILSON (contact)

PROGRAM_OFFICER_NAME: SPARER, OLIVIA CAHN

PROJECT_TERMS: Address;Adolescent;Adult;Affect;Age;Applied Research;Area;Award;biodefense;Biological Assay;Biological Products;Budgets;Child;Clinical;Clinical Research;clinical research site;clinical trial implementation;Clinical Trials;Collaborations;Communicable Diseases;Compensation;Consent Forms;Data Analyses;data dissemination;design;Development;Devices;Diagnostic;Disease;Disease Outbreaks;Elderly;Emerging Communicable Diseases;emerging pathogen;Enrollment;Ensure;Enteral;enteric pathogen;Epidemiology;Evaluation;Faculty;Future;Goals;Group Structure;Human;Immunocompromised Host;Infant;Infection;infectious disease treatment;Influenza;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H5N1 Subtype;influenza virus vaccine;innovation;Intervention Trial;investigator-initiated trial;Laboratories;Leadership;Letters;Life;Manuals;Medical center;medical specialties;Mentors;Methods;Microbiology;Mission;Modeling;Modification;Morbidity - disease rate;mortality;Multicenter Studies;National Institute of Allergy and Infectious Disease;neglected tropical diseases;Norovirus;novel;Ohio;operation;organizational structure;Outpatients;Participant;Pediatric Hospitals;Performance;Persons;Phase;Population;predictive marker;Pregnant Women;Preparation;prevent;Prevention;Preventive;Prognostic Marker;Protocols documentation;Public Health;Publications;Quality Control;Recording of previous events;recruit;Research Design;Research Personnel;respiratory pathogen;Respiratory Tract Infections;response;Sexually Transmitted Diseases;Shigella sonnei;Site;Systems Biology;Technology;Testing;Therapeutic;tool;Training;trial design;U-Series Cooperative Agreements;United States National Institutes of Health;vaccine candidate;vaccine development;vaccine effectiveness;vaccine evaluation;vaccine trial;vaccine-induced immunity;Vaccines

PROJECT_TITLE: Cincinnati Children's Hospital Medical Center Vaccine and Treatment Evaluation Units (UM1 Clinical Trial Required)


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Prevention;Serious Mental Illness

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Depression is a recurrent illness and even with successful antidepressant treatment, older adults with late-life depression are at high risk of recurrence. However, neurobiological processes that contribute to vulnerability to recurrence are poorly understood, limiting our ability to target mechanisms in prevention studies. The current study will elucidate neurobiological contributors to recurrence, examine the interrelationship between recurrence and cognitive decline, and provide data on the predictive utility of clinical monitoring in older adults.

PI_NAMEs: ANDREESCU, CARMEN  (contact)

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: Acceleration;actigraphy;Affect;Affective;aging brain;anti-depressive agents;Behavioral;Clinical;clinical practice;Cognitive;cognitive function;cognitive load;cognitive performance;Data;Depressed mood;depressive symptoms;Development;Disease remission;Early Diagnosis;Ecological momentary assessment;Elderly;Environmental Monitoring;Equilibrium;executive function;Exhibits;experience;Functional Magnetic Resonance Imaging;Future;geriatric depression;Goals;high risk;Homeostasis;Impaired cognition;Individual;Laboratories;Longitudinal Studies;Measures;Mental Depression;Monitor;mood symptom;Moods;negative affect;network models;neural;neural network;Neurobiology;neuroimaging;Noise;older adult;Participant;Performance;Predictive Factor;predictive marker;Prevention;Process;prospective;Recording of previous events;Recovery;Recurrence;recurrent depression;Regulation;Reporting;Residual state;Risk;Risk Marker;rumination;Severities;Signal Transduction;single episode major depressive disorder;Site;Sleep;Stress;stress reactivity;Subgroup;Symptoms;Testing;Therapeutic Intervention;Time;Translating;young adult

PROJECT_TITLE: 2/3: Recurrence markers, cognitive burden and neurobiological homeostasis in late-life depression (REMBRANDT)


NIH_SPENDING_CATS: Biotechnology;Genetics;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project narrative  The apical extracellular matrix (aECM) forms the interface between tissues and the outside world, plays critical roles in organ development and function, and offers a highly accessible therapeutic target. This project will identify novel components of aECM and show how they lead to changes in aECM structure during development. It will reveal how aECM remodelling occurs and will suggest approaches to target this key cellular interface in the context of disease.

PI_NAMEs: HEIMAN, MAXWELL  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Adolescent;Adult;Afferent Neurons;Animals;Apical;Attention;Biological Assay;Caenorhabditis elegans;Cell surface;cell type;Cells;Chemicals;Cilia;Complex;course development;Cues;Data;density;Development;differential expression;Diffuse;Disease;Environment;Epithelial Cells;Epithelium;Event;Exposure to;Extracellular Matrix;Extracellular Matrix Proteins;Felis catus;Fluorescence;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;genetic manipulation;Genetic Screening;Hermaphroditism;In Vitro;in vivo;innovation;Lead;Life;male;Modeling;Morphogenesis;mutant;nanoscale;Neuroglia;Neurons;Neurotransmitters;novel;Organ;organ growth;Organism;Play;prevent;Process;programs;Protein Family;Proteins;Regulatory Pathway;Role;Sense Organs;Sensory;sex;Shapes;Structure;Surface;System;targeted delivery;Testing;Therapeutic;therapeutic target;Tissue Engineering;Tissues;tool;transcription factor;Transducers;Tube;Visualization;Work

PROJECT_TITLE: Developmentally Programmed Remodeling of Apical ECM

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Granulomas drive the course of pulmonary tuberculosis disease and treatment, but we lack detailed understanding of how granuloma features interact with immune function and the bacterial pathogen. In this project, we will develop and utilize a geospatial information system for tuberculosis granulomas to provide new insights into granulomas during disease and treatment.

PI_NAMEs: ALDRIDGE, BREE BEARDSLEY;RENGARAJAN, JYOTHI  (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Activities of Daily Living;Affect;Animals;Antibiotic Therapy;Antigens;antimicrobial;Architecture;Bacteria;Bacterial Physiology;Cell Physiology;cell type;Cells;Clinical;Communication;Computational Biology;Computer Analysis;Computer Models;Containment;Data;design;Development;Disease;Disease Outcome;Drug Tolerance;Enzymes;Formalin;Gene Expression;Geographic Information Systems;Granuloma;Growth;Human;imaging modality;Immune;immune function;Immunofluorescence Immunologic;Immunology;immunopathology;Immunophenotyping;In Situ;Individual;Infection;Information Systems;inhibitor;insight;Investigation;Lesion;Lung;Macaca;Macaca mulatta;Macrophage;Maps;Metabolic;Modeling;multidisciplinary;Mycobacterium tuberculosis;nonhuman primate;novel;novel therapeutics;pathogen;Pathogenesis;pathogenic bacteria;Pathologic;Periodicity;permissiveness;PET/CT scan;Pharmaceutical Preparations;Physiological;Physiology;Predisposition;Procedures;pulmonary granuloma;Pulmonary Tuberculosis;response;scaffold;single-cell RNA sequencing;Stress;Structure of parenchyma of lung;Systems Biology;T cell response;T-Lymphocyte;Techniques;Technology;Testing;Therapeutic;tissue fixing;Tissues;tool;transcriptomics;Treatment Protocols;Tryptophan;Tryptophan 2,3 Dioxygenase;Tuberculosis;tuberculosis granuloma;tumor-immune system interactions;virtual

PROJECT_TITLE: Deep spatial immune profiling of granulomas and M. tuberculosis adaptation to disease and treatment


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Lack of caregiving preparedness is prominent and persistent among care partners of patients living with Alzheimer’s disease and related dementias (ADRD) and associated with increased risk for adverse clinical outcomes for patients living with ADRD, and increased levels of burden, depression, and morbidity for care partners. Engaging key stakeholders to adapt the standardized Care Partner Hospital Assessment Tool for hospital-based dementia care will expand its potential reach. Further, findings from this pilot randomized controlled trial will enable future efficacy trials to advance the refinement and implementation of the decision- support tool that can enhance caregiving preparedness to improve health outcomes after hospital discharge.

PI_NAMEs: FIELDS, BETH  (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Acceleration;acute care;Address;Adherence;Administrator;Adult;adverse outcome;Aging;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Assessment tool;Biometry;care delivery;career;career development;Caregivers;caregiving;Caring;Clinical;Clinical Trials;Clinical Trials Design;Cognitive;Collaborations;Conduct Clinical Trials;Consensus;Data;Decision Support Model;Delirium;dementia care;dementia caregiving;design;Development;Development Plans;efficacy evaluation;efficacy trial;Eligibility Determination;Ensure;Environment;Ethics;Event;Exclusion;experience;falls;Family Caregiver;Family member;Feeling;flexibility;Friends;Future;Goals;Health;Healthcare Systems;hospital care;hospital patient care;hospital readmission;Hospitalization;hospitalization rates;Hospitals;human centered design;Impaired cognition;improved;Institution;Intervention;iterative design;Knowledge;Leadership;Long-Term Care for Elderly;Measures;Medical;Mental Depression;Mentors;Mentorship;Modeling;Morbidity - disease rate;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;pilot test;Policies;post intervention;preference;Preparation;primary outcome;Process;programs;prototype;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Readiness;Recommendation;recruit;Reporting;Research;Risk;Role;Safety;satisfaction;Science;Scientist;screening;screening, brief intervention, referral, and treatment;Senior Scientist;skills;Standardization;standardized care;Statistical Data Interpretation;Stress;support tools;System;Testing;Training;treatment as usual;United States National Institutes of Health;usability;videoconference;Work

PROJECT_TITLE: Adapting and Testing the Care Partner Hospital Assessment Tool (CHAT) for Use in Dementia Care

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Infectious Diseases;Inflammatory Bowel Disease

ORG_CITY: Los Angeles

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative The proposed research is relevant to public health because autoimmune diseases, increasing in prevalence, is the top cause of morbidity in women in the United States; and despite significant advances in care, therapeutics usually lead to severe adverse effects due to insufficient selectivity. The proposed research is relevant to the NIH’s mission of reducing illness and disability because we will understand the pathogenic features distinguishing autoreactive T cell subset from normal cells, and this discovery will lead to new therapeutics for autoimmune diseases with substantially improved selectivity and reduced side effects.

PI_NAMEs: HE, ZHIHENG  (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Adopted;Adverse effects;Affect;aldehyde dehydrogenase 1;American;Antibodies;Autoimmune;Autoimmune Diseases;Autoimmunity;autoreactive T cell;Biochemical;Biopsy;Blood;Carbon;Carbon Dioxide;Caring;Cell Physiology;Cell Reprogramming;Cells;Classification;cofactor;conditional knockout;cytokine;Data;Development;disability;Dissection;Enzymes;Evaluation;Exposure to;Family member;Fatal Outcome;FDA approved;Future;Gene Expression Profile;Genetic Transcription;Grant;Human;IL17 gene;improved;in vivo;Infection;Infection Control;Inflammation;Inflammatory;Inflammatory Bowel Diseases;inhibitor;innovation;interleukin-23;Knowledge;Lead;Measures;Metabolic;Metabolism;Methylation;microbiota;Mission;Modeling;mouse model;Mus;Mutation;Normal Cell;novel;novel therapeutics;Outcome;pathogen;Pathogenicity;Patients;Pharmaceutical Preparations;Play;Population;Prevalence;prospective;Public Health;Publications;Regimen;Regulation;Repression;Research;Risk;Role;Sampling;Serine;side effect;small molecule;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Time;Tissues;transcription factor;transcriptional reprogramming;transcriptome sequencing;Tuberculosis;United States;United States National Institutes of Health;Up-Regulation;women's morbidity

PROJECT_TITLE: Dissecting functions of IL-23-dependent inflammatory Th17 cells

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The U.S. aging population is rapidly becoming more racially and ethnically diverse, and better understanding of persistent disparities in dementia diagnosis and care is an urgent research and public health priority. This project will address critical unanswered questions about the associations of social determinants of health with diagnostic and access to care outcomes in a nationally representative cohort of racially and ethnically diverse Medicare beneficiaries. Results will elucidate the mechanisms underlying disparities in ADRD healthcare and will contribute to development of healthcare policy strategies and targeted interventions aimed at reducing inequities in aging.

PI_NAMEs: TSOY, ELENA  (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Address;Age;age effect;Aging;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Asian;beneficiary;Black American;Black race;care outcomes;Caring;Characteristics;clinical care;clinical practice;cohort;Communities;comorbidity;Data;Data Analyses;Data Set;Dementia;dementia care;dementia risk;deprivation;Development;Diagnosis;Diagnostic;Diagnostic Services;Discrimination;Disease;Disparity;Distal;Education;Enrollment;Epidemiology;ethnic disparity;ethnic diversity;Ethnic Origin;Etiology;Evaluation;experience;Goals;Health;health care disparity;health disparity;health inequalities;Health Policy;Health Services Accessibility;Healthcare;Healthcare Systems;Hispanic;Hispanic Americans;indexing;Inequity;interest;Intervention;Laboratory Study;Link;Mediating;Mediator;medical specialties;Medicare;National Institute on Aging;neighborhood disadvantage;neuroimaging;Not Hispanic or Latino;older adult;Outcome;Pathway interactions;Play;Policies;Population;programs;Public Health;public health priorities;Race;racial disparity;racial diversity;Recommendation;Research;Research Priority;Role;Sampling;Sampling Studies;segregation;Services;sex;social;social determinants;social factors;social health determinants;social influence;socioeconomic disadvantage;Specificity;Surveys;Testing;theories;United States Centers for Medicare and Medicaid Services;Vulnerable Populations

PROJECT_TITLE: Social determinants of racial and ethnic disparities in ADRD diagnostic pathways

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Bedaquiline and pretomanid are medications from the first new antibiotic classes approved for tuberculosis (TB) by the FDA in 40 years; linezolid was originally developed to treat Gram-positive bacteria but has been found to be effective against TB. Combination treatment regimens using these new drugs have transformed the treatment of drug-resistant TB; however, emergence of resistance to these drugs would undermine the utility of these treatment regimens. We will utilize genomic sequencing, microbiologic and geospatial data, to study the emergence and expansion of resistance to bedaquiline, pretomanid and linezolid in South Africa; this study will provide information that is vital for preserving the effectiveness and ensuring the successful global scale-up of these lifesaving treatment regimens.

PI_NAMEs: GANDHI, NEEL RAJNIKANT;MATHEMA, BARUN  (contact);OMAR, SHAHEED VALLY

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Biological;Biological Assay;cellular targeting;Clinical;Clonality;Combined Modality Therapy;Country;Data;Development;diagnostic assay;Dose;drug repurposing;Drug resistance;Drug resistance in tuberculosis;Early identification;Effectiveness;Ensure;Epidemic;Epidemiology;Evolution;Exhibits;extensive drug resistance;Extreme drug resistant tuberculosis;Genes;genetic analysis;Genetic Polymorphism;Genetic Variation;genome sequencing;Genomics;Genotype;Geography;Gram-Positive Bacteria;HIV/TB;improved;Incidence;isoniazid;Life;Linezolid;Minimum Inhibitory Concentration measurement;Molecular;Monitor;Moxifloxacin;Multi-Drug Resistance;Multidrug-Resistant Tuberculosis;mutant;Mutation;Natural History;Nature;novel;novel antibiotic class;novel therapeutics;Oral;Outcome;Patients;Pharmaceutical Preparations;Pharmacoepidemiology;Phenotype;Population;Predisposition;preservation;pressure;Prevalence;programs;prospective;Prospective Studies;Province;Rapid diagnostics;Recommendation;Regimen;Resistance;resistance mutation;resistant strain;scale up;South Africa;Testing;Time;transmission process;Treatment Protocols;Tuberculosis;tuberculosis drugs;tuberculosis treatment;Vertebral column;whole genome;World Health Organization

PROJECT_TITLE: Emergence of bedaquiline, pretomanid and linezolid resistance after implementation of new drug-resistant tuberculosis regimens in South Africa

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-J(90)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PHR: Project Narrative Asian American women have remarkably high rates of lung cancer, despite that the great majority of them do not smoke; this is a health inequity that has not received the attention that it deserves. Elucidation of lung cancer risk factors among never-smoking Asian American women has the potential to inform the design of targeted interventions to reduce their high burden of this disease.

PI_NAMEs: CHEN, MOON SHAO-CHUANG;CHENG, IONA C;GOMEZ, SCARLETT L (contact)

PROGRAM_OFFICER_NAME: MARTIN, IMAN

PROJECT_TERMS: Adenocarcinoma;Affect;Age;Air Pollutants;ambient air pollution;American;Asia;Asian Americans;Asian Women;Attention;attributable risk;Body Size;burden of illness;California;cancer epidemiology;Cancer Etiology;cancer health disparity;cancer risk;case control;Case/Control Studies;Cessation of life;Chinese;cohort;Communicable Diseases;community engaged research;cooking;Data;Data Set;design;Diagnosis;Disease;Disparity;East Asian;Environmental Epidemiology;Epidermal Growth Factor Receptor;Ethnic Origin;Ethnic Population;Etiology;exome sequencing;Exposure to;Female;Frequencies;Genetic;genomic data;health inequalities;Histology;hormone therapy;Hormone use;improved;Incidence;Individual;indoor concentrations;indoor pollutant;Intervention;Japanese;Joints;Koreans;Low Prevalence;Malignant neoplasm of lung;Malignant Neoplasms;Medical Oncology;Methods;Molecular Epidemiology;Mutation;neoplasm registry;never smoker;never smoking;Normal tissue morphology;Not Hispanic or Latino;novel;Oils;Pathway interactions;Population;population based;Prevention strategy;racial population;Reproductive History;Research;Risk Factors;Science;Smoke;Smoking;Smoking History;smoking prevalence;Social Environment;social epidemiology;Somatic Mutation;Testing;Tissue Sample;trend;tumor;United States;White Women;Woman

PROJECT_TITLE: Elucidating Lung Cancer Etiology Among Asian American Female Never Smokers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-A(55)R]


NIH_SPENDING_CATS: Atherosclerosis;Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention

PHR: PROJECT NARRATIVE The proposed research aims at understanding key mechanisms in the response to vascular injury with the ultimate goal of developing novel treatment strategies. It is relevant to public health because blood vessels respond to injury by forming blockages that can cause heart attacks and strokes, the most common causes of death in our nation. Thus, the proposed research is directly relevant to the part of the NIH’s mission that pertains to foster research strategies, and their applications as a basis for protecting and improving health.

PI_NAMEs: GRUMBACH, ISABELLA MARIA (contact);THIEL, WILLIAM H

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Address;Angioplasty;aptamer;Balloon Angioplasty;Binding;Biological Assay;Biological Process;Blood Vessels;cardiovascular health;Cardiovascular system;Cause of Death;Cell Cycle Progression;Cell Cycle Regulation;Cell Line;Citric Acid Cycle;Coronary;coronary angioplasty;Crista ampullaris;Data;Development;Disease;EF Hand Motifs;Electron Transport;Endothelial Cells;Event;Fostering;G1/S Transition;Goals;Guanosine Triphosphate Phosphohydrolases;Health;human disease;Hyperplasia;Impairment;improved;in vivo;Injury;innovation;insight;Knowledge;Medicine;Metabolic;Mission;Mitochondria;Mitosis;Morphology;mTOR Inhibitor;Mus;mutant;Myocardial Infarction;neointima formation;novel;novel strategies;novel therapeutics;Outcome;Outer Mitochondrial Membrane;Paclitaxel;Peripheral;Pilot Projects;Positioning Attribute;prevent;Process;Production;Proliferating;Proteins;Public Health;Regulation;Reporting;Research;response;restenosis;RNA;Signal Transduction;Site;Small Interfering RNA;Smooth Muscle Myocytes;standard care;Stenosis;Stents;Stroke;targeted treatment;Testing;Therapeutic;tool;trafficking;treatment strategy;United States National Institutes of Health;uptake;Vascular Diseases;vascular injury;Vascular Smooth Muscle;vascular smooth muscle cell proliferation

PROJECT_TITLE: Leveraging the mitochondrial regulator MIRO1 to prevent neointimal hyperplasia

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: PEDIATRICS

PHR: Project Narrative Provision of equitable care and support to Black and Latinx transgender youth and their caregivers is a crucial step in addressing the poor psychosocial outcomes experienced by Black and Latinx transgender persons in adulthood that include depression, substance abuse, and suicidality. The proposed plan will help answer questions about how to optimally support Black and Latinx transgender youth. Findings from the proposed plan will be relevant to the academic and public health arenas and ultimately further the field of pediatric transgender medicine in addressing racial disparities in mental health outcomes and gender affirmation.

PI_NAMEs: VANCE, STANLEY RAY (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;Adolescent;Adolescent and Young Adult;Adolescent Medicine;Adult;Adult women;Affect;Anxiety;Applications Grants;Attention;Award;Black race;career;career development;caregiver interventions;Caregivers;Caring;Child;Childhood;cisgender;Clinic;Color;Communities;community advisory board;community based research;community engaged research;community organizations;Consent;cultural values;culturally appropriate intervention;Data;depressive symptoms;design;Development;Discipline;Disparity;Equity;Ethnic Origin;Ethnic Population;Evaluation;experience;Face;Family;Fellowship;Focus Groups;Fostering;Gender;gender affirmation;gender affirming care;gender diversity;Gender Identity;gender minority group;Goals;Health;health disparity;HIV risk;Home;hormone therapy;implementation intervention;improved;informant;Intervention;intervention refinement;Interview;K-Series Research Career Programs;Latinx;lens;Literature;maltreatment;Manuals;Measures;Medical;Medicine;Mental Depression;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentors;method development;Methodology;Minority Groups;Modeling;Mood Disorders;Names;Online Systems;Outcome;Parental Consent;parental influence;Parents;peer;Peer Group;peer support;Persons;pilot test;Play;Population;Positioning Attribute;Prevention;primary caregiver;Process;psychosocial outcome;Public Health;Qualitative Methods;Race;racial disparity;racial population;racism;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;research and development;Research Personnel;Research Training;Resources;Role;Scholars Program;service providers;skill acquisition;skills;social;social stigma;Social support;Structure;Substance abuse problem;suicidal;Support Groups;Symptoms;Testing;therapy design;therapy development;Time;Training;transgender;transphobia;United States National Institutes of Health;virtual;Work;young adult;Youth

PROJECT_TITLE: Examining Contributors to Disparities in Gender Affirmation and Mental Health among Black and Latinx Transgender Youth


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Mental Illness;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: 5HT1ARs are highly implicated in mood disorders and SSRI treatment efficacy. More recently, 5HT1ARs have also been implicated in both cognitive and non-cognitive symptoms of Alzheimer’s disease. Importantly, women are more likely to suffer from these disorders, and have a significantly greater response to SSRIs, as compared to men. The mechanisms underlying sex-dependent vulnerability to these diseases and sensitivity to SSRI treatment are largely unexplored. Results gained from our proposed studies will provide an entry point towards better understanding of the sex differences associated with these diseases and SSRI treatment efficacy. Ultimately, information gained from these studies will enable development of personalized strategies to treat these diseases and improve antidepressant efficacy by targeting adult hippocampal neurogenesis.

PI_NAMEs: SONG, JUAN  (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Acceleration;Adult;adult neurogenesis;Alzheimer's Disease;anti-depressive agents;Anxiety;Behavior;Behavioral;Binding;cell type;Cells;Cognitive;Data;density;dentate gyrus;Development;Disease;Electrophysiology (science);Female;Fiber;Functional disorder;Genetic;Hippocampus;Impairment;improved;in vivo;Link;Major Depressive Disorder;Mediating;Membrane;Membrane Potentials;men;Mood Disorders;Mus;nerve stem cell;neurogenesis;Neurons;Newborn Infant;newborn neuron;Pattern;personalized strategies;Photometry;Play;Process;Production;Proliferating;receptor;receptor expression;Regulation;response;Role;selective expression;Selective Serotonin Reuptake Inhibitor;serotonergic regulation;Serotonin;sex;Sex Differences;Signal Transduction;Slice;Stimulus;Stress;Symptoms;System;Testing;Treatment Efficacy;Woman

PROJECT_TITLE: Sex-dependent role of 5HT1A receptors in adult neurogenesis and hippocampal function

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Cannabinoid Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Tobacco;Underage Drinking

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: Project Narrative Reducing harms associated with early and problem use of alcohol, nicotine, and cannabis among Black and Latinx youth requires insight into the family and community level cultural and environmental factors most salient to substance use risk in Black and Latinx girls and boys from the pre- to mid-adolescent years. The proposed secondary data analysis project focuses on cultural and environmental factors of particular relevance to members of racial/ethnic minority groups, such as racial/ethnic discrimination and ethnic identity, as well as those more prevalent in Black and Latinx than White youth (e.g., neighborhood disadvantage, religious involvement) to characterize pathways of substance use - from cognitions that precede first use to early onset regular use - from ages 9 to 16. Findings will lay the groundwork for cultural tailoring of substance use prevention strategies for Black and Latinx youth toward the broader goal of reducing substance use related health disparities.

PI_NAMEs: SARTOR, CAROLYN E (contact)

PROJECT_TERMS: Accounting;Acculturation;Address;Adolescence;Adolescent;Adolescent Development;Age;Alcohol abuse;Alcohol consumption;Alcohols;Beer;Behavior;Black Populations;Black race;black women;boys;Brain;Cannabis;Cognition;cognitive development;cohort;Communities;Data;Data Analyses;Development;distilled alcoholic beverage;early adolescence;early onset;eighth grade;Electronic cigarette;electronic cigarette use;Environmental Risk Factor;ethnic difference;ethnic discrimination;ethnic identity;ethnic minority population;Ethnic Origin;Ethnic Population;Etiology;Expectancy;experience;Exposure to;Family;Female;Foundations;Gender;girls;Goals;Harm Reduction;health disparity;High Prevalence;insight;Knowledge;Latinx;Latinx population;Link;Longitudinal Studies;male;marijuana use;marijuana vaping;member;Methodology;Methods;Modeling;modifiable risk;neighborhood disadvantage;Neighborhoods;Nicotine;nicotine use;novel;parental monitoring;Parents;Participant;Pathway interactions;Pattern;person centered;Population;population based;Prevalence;Prevention;Prevention program;Prevention strategy;prospective;protective factors;Race;racial difference;racial discrimination;racial minority population;racial population;Recording of previous events;reduced substance use;Religion;Reporting;Risk;Risk Factors;Risk Reduction;Site;Socioeconomic Status;Source;Specificity;Subgroup;substance use;substance use prevention;Survival Analysis;Time;Trauma;vaping;Variant;White Women;Youth

PROJECT_TITLE: Cultural and Environmental Influences on Precursors to and Early Stages of Alcohol, Nicotine, and Cannabis Use in Black and Latinx Youth

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Hearing Loss;Neurosciences;Prevention;Rehabilitation

ORG_CITY: NEW YORK

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Public Health Relevance Statement Cochlear implants are remarkable neuroprosthetic devices that restore hearing to people who are profoundly deaf, and are the most widely applied brain-machine interface (500,000+ people worldwide). Outcomes can be highly variable with some people struggling to hear at all- the leading hypothesis is that poor implant use results from lack of neuroplasticity in the auditory system of those subjects rather than device failure per se, but there are little direct data on neural mechanisms of implant use and training. The experiments to be performed in this proposal provide essential data on basic mechanisms of neuromodulation and plasticity in the auditory cortex, required for improvement of prosthetic design and therapeutic strategies for treatment of deafness with implants.

PI_NAMEs: FROEMKE, ROBERT CROOKS (contact);SVIRSKY, MARIO A

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustics;Adult;Americas;Animals;Auditory;Auditory area;Auditory Perception;Auditory system;basal forebrain;Behavior;Behavioral;behavioral response;behavioral study;Bilateral;Biomedical Engineering;Biomedical Research;Brain;brain machine interface;Brain region;Brain Stem;Cell Nucleus;Cells;cholinergic;Clinical;Cochlea;Cochlear implant procedure;Cochlear Implants;Collaborations;Complex;Comprehension;Data;deaf;deafening;deafness;Devices;Electrocorticogram;Electrophysiology (science);Equipment Malfunction;experience;experimental study;Fiber;Goals;Hearing;hearing measurement;hearing restoration;human subject;imaging modality;Imaging technology;Implant;implantation;improved;improved outcome;in vivo;Individual;individual variation;information processing;inhibitory neuron;language perception;Learning;locus ceruleus structure;Measures;medical schools;Memory;Midbrain structure;Modeling;Monitor;multi-electrode arrays;neural;neural circuit;neural correlate;neuromechanism;Neuronal Plasticity;Neurons;neurophysiology;neuroprosthesis;neuroregulation;Neurosciences;noradrenergic;normal hearing;Optics;optogenetics;Otolaryngology;Outcome;Output;Patient-Focused Outcomes;Pattern;Perceptual learning;Performance;Persons;Photometry;Physiological;Population;predictive marker;Prosthesis Design;Psychophysics;public health relevance;Publications;Rat Transgene;Rattus;Recovery;recruit;Reporting;response;Rodent;Sensory;Shapes;Signal Transduction;sound;Source;Speech;Synapses;Synaptic plasticity;System;Task Performances;Techniques;Testing;Thalamic structure;Therapeutic;Training;treatment strategy;United States;Whole-Cell Recordings

PROJECT_TITLE: Synaptic basis of perceptual learning with cochlear implants in rat auditory cortex - Renewal

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]