NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Regenerative Medicine

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: NARRATIVE A significant barrier in developing effective therapies to prevent restenosis is our lack of understanding of the cellular and molecular mechanisms controlling endothelial cell regeneration during injury. This application seeks to remove this critical roadblock by bringing information associated to how, where, for how long and under which circumstances endothelial cells are induced to proliferate in the context of a fully functional vessel. Our proposal addresses the exciting possibility that manipulation of specific pathways could reset the entry of endothelial cells into a proliferative state and represent a powerful approach to address vascular repair in humans.

PI_NAMEs: IRUELA-ARISPE, M. LUISA  (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Acceleration;Acute;Address;Aging;angiogenesis;Award;Biological Process;blood perfusion;Blood Vessels;Cell Cycle;Cell Polarity;cell regeneration;Cells;Cellular biology;Chemical Injury;chromatin remodeling;Chronic;Chronic Disease;Data;effective therapy;Endothelial Cells;endothelial regeneration;endothelial repair;Endothelium;Gene Expression Profile;Genetic;Goals;Grant;Growth;healing;Heterogeneity;Hour;Human;Impairment;in vivo;Inflammation;Injury;intercalation;Intercellular Junctions;Intervention;Knowledge;Length;Mediating;Medical;Metabolism;Molecular;monolayer;Mus;National Heart, Lung, and Blood Institute;Natural regeneration;new therapeutic target;Outcome;Pathway interactions;Physiological;prevent;Process;progenitor;Proliferating;regenerative;repaired;Research Personnel;response;restenosis;Series;Signal Transduction;Stents;Stress;Therapeutic Intervention;translational impact;translational potential;Trauma;Tube;Tunica Intima;vascular bed;Width;wound

PROJECT_TITLE: Vascular Growth and Regeneration


ADMINISTERING_IC: AR

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Traumatic and non-traumatic musculoskeletal disorders are responsible for substantial morbidity, pain and disability, affecting athletes, soldiers, active working people and the elder population. We propose to generate suturable 3D vascularized muscle tissues from human pluripotent stem cells derived myogenic precursor cells (iPSC-MPCs) embedded in biomimetic biomaterials using advanced bioprinting techniques. The successful development of this technology will be applicable to other areas of regenerative medicine and can potentially be utilized for the treatment of skeletal muscle loss.

PI_NAMEs: SHIN, SU RYON  (contact);TAMAYOL, ALI

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Affect;Alginates;Allografting;angiogenesis;Architecture;Area;Autologous Transplantation;Biocompatible Materials;bioink;biomaterial compatibility;Biomimetics;bioprinting;Blood capillaries;Blood Vessels;cell assembly;Cell Survival;Cells;Characteristics;Cicatrix;Clinical;clinically relevant;Collagen;Complex;directed differentiation;disability;Elderly;Electrophysiology (science);Electrospinning;Endothelial Cells;Endothelium;Engineering;Extracellular Matrix;Fiber;Fibrosis;Functional impairment;Functional Regeneration;functional restoration;Gelatin;Growth;Growth Factor;healing;Hematopoietic;human pluripotent stem cell;Hydrogels;Image;Immune response;Impairment;Implant;implantation;improved;in vivo;induced pluripotent stem cell;Infection;injured;Injury;Insulin-Like Growth Factor I;Invaded;Kinetics;Lasers;mechanical properties;Methods;migration;Modeling;Morbidity - disease rate;mouse model;Muscle;muscle engineering;Muscle Fibers;muscle form;Muscle function;muscle regeneration;Muscle satellite cell;Muscular Atrophy;Musculoskeletal Diseases;Myoblasts;nanofiber;nerve injury;Nerve Regeneration;neuromuscular;Neuromuscular Junction;Nude Mice;Operative Surgical Procedures;Pain;Patients;personalized medicine;Persons;physical property;Physiological;pluripotent stem cell differentiation;poly(glycerol-sebacate);Population;Positioning Attribute;precursor cell;Printing;Production;proliferation potential;Protocols documentation;quadriceps muscle;Quality of life;Recovery;regeneration function;Regenerative capacity;Regenerative Medicine;repaired;Reproducibility;restoration;scaffold;Scheme;self assembly;Site;Skeletal Muscle;skeletal muscle wasting;Soldier;stem cell delivery;subcutaneous;Surgical sutures;System;Techniques;technology development;Testing;Therapeutic;Thick;Tissue constructs;Tissue Grafts;Tissues;traumatic event;Traumatic injury;treadmill;Vascular blood supply;Vascular regeneration;Vascularization;vehicular accident;volumetric muscle loss

PROJECT_TITLE: Suturable bioprinted vascularized muscle constructs for treatment of skeletal muscle loss

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHAMPAIGN

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: PROJECT NARRATIVE  Natural products hold a crucial role in developing novel molecular tools, such as pharmaceutical agents and probes. Specifically, they provide a major driving force for discovering new chemotherapeutics and are the primary source of compounds for the effective treatment of cancer and infectious diseases. The proposed research aims to develop new strategies and methods to prepare and study promising small bioactive molecules based on complex natural products that are not readily accessible yet would be highly desirable if brought within the realm of medicinal chemistry.

PI_NAMEs: SARLAH, DAVID  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Acceleration;Adverse effects;Affect;analog;anti-cancer;Anti-Infective Agents;anticancer activity;Antineoplastic Agents;Architecture;bioactive natural products;Biological;Biological Testing;Biology;Breathing;Cancer cell line;cancer therapy;carcinogenicity;Cessation of life;Chemical Engineering;Chemical Structure;chemical synthesis;Chemicals;Chemistry;clinical development;Collaborations;Communicable Diseases;Complex;Creativeness;Cyclization;cytotoxic;Development;Disease;driving force;drug development;effective therapy;Evaluation;Excision;fighting;flexibility;Goals;Human;Indenes;infectious disease treatment;Investigation;Isomerism;Knowledge;Lead;Malignant Neoplasms;Medicine;Metabolic;metabolic profile;Metastatic/Recurrent;Methodology;Methods;Molecular;Molecular Mechanisms of Action;Molecular Probes;Molecular Target;molecular targeted therapies;Mutation;Natural Products;Nature;Neoplasm Metastasis;novel;novel strategies;Oncogenes;Oncology;Operative Surgical Procedures;Organic Synthesis;Organism;Outcome;pathogen;Pathogenicity;Patients;Periodicity;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacologic Substance;Polyenes;Preparation;prevent;Primary Neoplasm;Prodrugs;programs;Property;Radiation therapy;Rationalization;Reactive Inhibition;Research;Resistance;Role;scaffold;Signal Pathway;Signal Transduction;small molecule;Source;Specificity;standard of care;Stereoisomer;Structure;Terpenes;Testing;Therapeutic;tool;Toxic effect;Toxicology;tumor;Work

PROJECT_TITLE: Synthesis of Biologically Active Terpenoids

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ADMINISTERING_IC: AT

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Complementary and Integrative Health;Neurosciences;Stroke

ORG_CITY: CLEVELAND

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Narrative In spite of decades of study, the interoceptive sense of movement remains poorly understood. This ambiguity prevents us from understanding the basic nature of the relationships between our reflexes and voluntary actions, between the predictions our brains make about how our bodies move and how we actually sense those movements, and between how our brains feel movement and the neural circuitry that makes this happen. Everything we learn about kinesthesia in this context is directly translatable into our clinical care model for advanced neural-machine interface amputees and individuals with stroke.

PI_NAMEs: MARASCO, PAUL D. (contact)

PROGRAM_OFFICER_NAME: BELFER, INNA

PROJECT_TERMS: Ablation;Adult;Amputation;Amputees;Area;Bionics;Brain;calbindin;Calcium;Caliber;Characteristics;Classification;Clinical;clinical application;clinical care;Code;Complex;cortex mapping;design;Disease;Electrophysiology (science);Environment;Esthesia;Evaluation;Exhibits;Feedback;Focal Dystonias;Foundations;Frequencies;frontier;Genetic;Golgi Tendon Organs;Histologic;Human;Image;Immunologics;improved;Individual;Infrastructure;Interoception;Intervention;Intramuscular;Kinesthesis;Kinesthetic Illusions;Knowledge;Learning;limb movement;Link;Liquid substance;Mediating;Modeling;Molecular;Morphology;Motor;motor control;motor deficit;Movement;Mus;Muscle;Muscle Contraction;Muscle Fibers;Muscle Spindles;musculoskeletal injury;Nature;neural;neural circuit;Neurons;novel;Outcome;Parkinson Disease;Perception;Peripheral;Peripheral Nervous System Diseases;Population;preservation;prevent;Property;Proprioceptor;Prosthesis;Publishing;Rattus;receptor;Reflex action;response;restoration;Role;sensor;Sensory;Sensory Receptors;sensory stimulus;Skeletal Muscle;Stimulus;Stroke;stroke model;stroke patient;success;System;Testing;theories;tool;transcriptome;Translating;translational medicine;Translational Research;Translations;United States National Institutes of Health;vibration;Visit;Work

PROJECT_TITLE: Sensing active movement of the self: reconsidering the cellular basis kinesthesia

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Asthma;Clinical Research;Genetics;Health Effects of Indoor Air Pollution;Immunotherapy;Lung

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Foxp3+ regulatory T cells (Tregs) are potent suppressors of inflammation, including allergic inflammation that underlies the most common type of asthma. We have found that allergen-specific Tregs that persist in the lung are critical for suppressing the recall response to allergen but their numbers appear to wane over time. The goal of this project therefore is to understand the mechanisms of resident Treg cell persistence and function in the allergic lung in order to enhance the durability and function of resident Treg as a new treatment strategy for asthma.

PI_NAMEs: LUSTER, ANDREW D (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Adoptive Transfer;airborne allergen;airway hyperresponsiveness;airway immune response;airway inflammation;Allergens;Allergic;Allergic inflammation;allergic response;Anatomy;Antigens;Asthma;asthma model;Bone Marrow;CCL1 gene;CCL8 gene;CCR8 gene;CD4 Positive T Lymphocytes;Cell Proliferation;Cell Separation;Cells;chemokine;chemokine receptor;Chronic Disease;chronic inflammatory disease;cost estimate;CXCR;CXCR6 gene;cytokine;Effector Cell;efficacy evaluation;environmental allergen;eosinophil;Exhibits;experimental study;Extrinsic asthma;Failure;Flow Cytometry;FOXP3 gene;Frequencies;Generations;Genetic Transcription;Goals;Human;Immune response;Immune system;Immunohistochemistry;Immunosuppressive Agents;In Vitro;Individual;Inflammation;Inhalation;Ligands;Location;Lung;Maintenance;Mediating;Memory;Metaplasia;Modeling;MUC5AC gene;Mucins;Mucous body substance;Mus;novel therapeutic intervention;Pattern;Peptides;Phenotype;Play;Population;Positioning Attribute;Prevalence;Production;programs;Pulmonary Inflammation;Pyroglyphidae;Regulatory T-Lymphocyte;Reporter;Residencies;Resolution;response;Role;single-cell RNA sequencing;Specificity;Surface;System;T cell differentiation;T memory cell;Testing;Th2 Cells;Therapeutic;Time;Tissues;transcriptome sequencing;Transgenic Mice;Up-Regulation

PROJECT_TITLE: Allergen-specific lung-resident Tregs in asthma:  Targetable suppressors of resident memory Th2 cells

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE (Overall) The Rhode Island Hospital Injury Control COBRE will support the development of junior researchers into independent researchers capable of leading rigorous, innovative injury control research that changes practice and policy and improves health. This will be accomplished through the establishment of three cores to develop and sustain a multidisciplinary center of research excellence which provides mentorship and career development of early career faculty through research studies and a pilot study program.

PI_NAMEs: MELLO, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: Acceleration;Accident and Emergency department;Address;Advisory Committees;Age Years;career development;Cause of Death;Centers of Research Excellence;Child;Childhood;clinical predictors;Collaborations;combat;Committee Members;Derivation procedure;design;Development;digital;digital health;Discipline;Dissemination and Implementation;Doctor of Philosophy;Dryness;early-career faculty;Emergency Department patient;Emergency department visit;emerging adult;Ensure;Epidemic;Faculty;Fall prevention;Fracture;Funding;Future;Growth;Health;Hospitals;improved;Individual;Infrastructure;injured;Injury;injury burden;injury prevention;innovation;Institution;Lead;Leadership;Life Cycle Stages;marijuana use;Mentors;Mentorship;Mission;multidisciplinary;older adult;organizational structure;Pilot Projects;Policies;population health;Positioning Attribute;post-traumatic symptoms;preventive intervention;Production;programs;Prospective Studies;Research;Research Activity;Research Personnel;Research Project Grants;Research Proposals;research study;Research Support;research to practice;Rhode Island;Running;Science;Scientist;Seasons;senior faculty;Services;sound;telehealth;Training;trauma exposure;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: Rhode Island Hospital Injury Control Center for Biomedical Research Excellence (COBRE)


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Physical Injury - Accidents and Adverse Effects

PROJECT_TERMS: active control;acute care;Address;Advisory Committees;Age Years;Applications Grants;Award;Basic Science;Budgets;career;career development;Cause of Death;Centers of Research Excellence;clinical practice;community advisory board;Data;Dedications;Development;digital;Dryness;Emergency department visit;Ensure;Evaluation;Funding;Future;Goals;Grant;Grant Review;Growth;Health;Hospitals;improved;Individual;Infrastructure;injured;Injury;injury burden;injury prevention;innovation;Lead;meetings;Mentors;Mentorship;Methods;Mission;Monitor;organizational structure;Patients;Phase;Pilot Projects;Policies;population health;Positioning Attribute;Primary Prevention;programs;Progress Reports;Rehabilitation therapy;Reporting;Research;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Research Proposals;research study;Research Support;research to practice;Rhode Island;Running;success;Surveys;Training;Training Activity;Translational Research;Traumatic Brain Injury;Update;Vocational Guidance

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding;Physical Injury - Accidents and Adverse Effects;Prevention

PI_NAMEs: BEAUDOIN, FRANCESCA  (contact)

PROJECT_TERMS: Acceleration;Address;adverse outcome;Age Years;Awareness;Centers of Research Excellence;Clinical;clinical practice;Code;Communication;Communities;community advisory board;Conduct Clinical Trials;Consultations;Coupled;data de-identification;Data Reporting;design;Development;Dissemination and Implementation;dissemination strategy;Educational Curriculum;Event;experience;Faculty;falls;Future;Goals;Health Policy;Hospitals;implementation science;Individual;informant;Infrastructure;Injury;injury burden;injury prevention;innovation;interdisciplinary collaboration;Learning;Life;life span;Measurement;member;Mentors;Mentorship;Methodological Studies;Methodology;Methods;Morbidity - disease rate;mortality;Non-accidental;novel;Observational Study;older adult;online resource;open source;Outcome;Patients;pediatric trauma;Pilot Projects;Policies;Policy Maker;population health;Post-Traumatic Stress Disorders;prevent;Process;Public Health;Recurrence;Research;Research Design;Research Personnel;Research Project Grants;research study;research to practice;Research Training;Rhode Island;Risk;Scientist;Series;skills;social media;sound;symposium;System;Technology;Time;tool;Training;training project;Translational Research;Translations;Trauma;Visual;Work

PROJECT_TITLE: Injury Control Research to Practice and Policy Core


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: MAYWOOD

ORG_DEPT: PHYSIOLOGY

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

PHR: PROJECT NARRATIVE Heart function vitally relies on well-controlled intracellular calcium regulation and abnormalities in this regulation can cause life-threatening arrhythmias and contractile dysfunction. This research project is focused on the main calcium handling protein SERCA. This research proposal is relevant to public health, as SERCA represents an attractive candidate for therapeutic targeting to improve calcium regulation and myocardial contraction in the diseased heart.

PI_NAMEs: ZIMA, ALEKSEY V (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Affect;Affinity;Amino Acids;Arrhythmia;ATP phosphohydrolase;Attention;Binding Sites;Biological;biophysical techniques;Calcium;Cardiac;Cardiac Myocytes;Clinical;Cysteine;Cytosol;Defect;design;Disabling;disulfide bond;Elements;Endoplasmic Reticulum;Functional disorder;Gene Delivery;Heart Diseases;Heart failure;heart function;Impairment;improved;in vivo;innovation;Life;loss of function;Measures;Molecular;molecular dynamics;Muscle Cells;Muscle Contraction;Muscle relaxation phase;mutant;Mutation;Myocardial Contraction;Myocardium;novel;novel therapeutic intervention;novel therapeutics;Optical Methods;Organelles;Outcome;Outcome Study;Oxidation-Reduction;Pathologic;Patients;Phenotype;phospholamban;Pilot Projects;Play;protein function;Proteins;Public Health;Pump;Regulation;Reporting;Research Project Grants;Research Proposals;Role;Sarcoplasmic Reticulum;sensor;Side;Site;Site-Directed Mutagenesis;Speed;Structure;targeted treatment;Techniques;Testing;therapeutic candidate;therapeutic target;uptake;Work

PROJECT_TITLE: New mechanisms of SERCA2a regulation: role of luminal calcium

STUDY_SECTION: ESTA

STUDY_SECTION_NAME: Electrical Signaling, Ion Transport, and Arrhythmias Study Section[ESTA]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Prevention

PI_NAMEs: RANNEY, MEGAN LARIN (contact)

PROJECT_TERMS: acceptability and feasibility;Achievement;aged;American;Big Data;Businesses;Cause of Death;Centers of Research Excellence;Clinical;Consultations;Data;Development;digital;digital health;efficacy trial;Equity;Evaluation;experience;Funding;Future;Generations;Goals;Grant;Health;health training;Hospitals;improved;Incidence;Individual;Industry;industry partner;Informatics;Injury;injury prevention;innovation;innovative technologies;Intervention;Measurement;Measures;mobile application;Modality;mortality;novel;Opioid;Persons;Physiologic Monitoring;Population;Populations at Risk;preventive intervention;programs;protective factors;Public Health;Qualitative Research;Research;Research Design;Research Personnel;Resources;Rhode Island;Risk Factors;Science;social media;social stigma;sound;Structure;support network;Technology Transfer;tertiary prevention;Testing;Text Messaging;Time;tool;Transportation;wearable device;Work

PROJECT_TITLE: Injury Control Digital Innovation Core


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: MILWAUKEE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: There is an urgent need to reverse the troubling losses from the physician-scientist pool, and to this problem, we have designed a physician scientist training program at the Medical College of Wisconsin that will recruit and train the next generation of physician scientists. Trainees will be immersed in a well-resourced and supportive program that is designed with specific milestones, training, and metrics. This will enable them to lead and complete research projects and acquire the skill set needed to successfully compete for grants to further their career as a physician-scientist junior faculty at the Medical College of Wisconsin or another academic institution in the U.S.

PI_NAMEs: EAPEN, MARY ;WIDLANSKY, MICHAEL E (contact)

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: American;Anesthesia procedures;Attention;Award;Basic Science;Benchmarking;Cardiology;Cardiovascular system;career;Certification;Clinical Research;clinical training;Department chair;design;Development;Doctor of Philosophy;Education;education research;eligible participant;Enrollment;Ensure;evidence base;expectation;experience;Exposure to;Faculty;Fellowship;Foundations;Funding;Goals;Grant;Health;Hematology;high school;Immersion;improved;Individual;innovation;Institution;interest;Internal Medicine;Investments;Knowledge acquisition;Lead;Leadership;Learning;Light;Manuscripts;medical schools;medical specialties;Medical Students;Medicine;meetings;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;National Heart, Lung, and Blood Institute;next generation;Operative Surgical Procedures;Pathway interactions;Pediatrics;Peer Review;physician-scientist training program;Physicians;Population;Positioning Attribute;Productivity;Program Development;programs;Publications;Publishing;Records;recruit;Research;Research Personnel;Research Project Grants;Research Training;Residencies;Resources;Science;Scientist;skill acquisition;skills;skills training;Structure;success;summer research;Surveys;Techniques;Time;Training;Training Programs;Translational Research;United States National Institutes of Health;university student;Wisconsin

PROJECT_TITLE: Medical College of Wisconsin Physician Scientist Immersion Program


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Data Science;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: DALLAS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative Deep learning (DL) via artificial intelligence (AI) neural networks is a powerful approach to construct accurate predictive computational models with applications across all life sciences. Existing models are biased because of an underlying assumption that the data used for training these DL networks are independent of each other and have been drawn from an identical distribution, which is untrue of biological datasets where samples are interdependent. This project will develop novel neural network architectures as powerful DL tools, made available as reusable software modules that can improve existing models with only a few lines of programming code, and will ultimately enable the generation of more accurate predictions and improve our ability to interpret biomedical data and what the models have learned which will be invaluable for study and treatment of human disease with an unprecedented degree of automation and precision.

PI_NAMEs: MONTILLO, ALBERT AMOS (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: 3-Dimensional;Accounting;Address;Algorithms;Alzheimer's Disease;Alzheimer's disease diagnosis;Architecture;Artificial Intelligence;autoencoder;Automation;base;Biological;Biological Assay;Biological Sciences;biomedical imaging;Blood;Brain;cancer cell;Cells;Classification;Code;Cognitive;Communities;Complex;Computer Models;Computer software;convolutional neural network;Data;Data Analyses;Data Correlations;Data Set;deep learning;deep learning model;Dependence;dimension reduction;feedforward neural network;Future;Generations;Glioma;Goals;Health Sciences;human disease;Image;improved;Individual;innovation;Institution;Learning;learning community;learning network;live cell imaging;Machine Learning;machine learning framework;Magnetic Resonance Imaging;Measurement;Measures;Medical;Medical Imaging;Methods;Methylation;Microscope;Microscopy;mild cognitive impairment;Modeling;Modification;multimodality;Nerve Degeneration;neural network;neural network architecture;novel;open source;Outcome;Participant;Patients;Performance;Peripheral Blood Mononuclear Cell;predictive modeling;preservation;Pythons;Recovery;resilience;Sampling;Site;statistics;success;TensorFlow;Testing;The Cancer Imaging Archive;Three-Dimensional Image;Tissues;tool;Training;transcriptome sequencing;Validation;vector;Visualization

PROJECT_TITLE: Correcting biases in deep learning models

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cannabinoid Research;Clinical Research;Emergency Care;Health Services;Mental Health;Mental Illness;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Substance Misuse

PI_NAMEs: BRICK, LESLIE ANN DALINE (contact)

PROJECT_TERMS: Accident and Emergency department;Acute;acute stress;acute symptom;Adult;Affect;Affective;aged;alcohol and other drug;Anxiety;anxiety reduction;anxiety states;Arousal;Behavior;Belief;biological adaptation to stress;Cannabinoids;Cannabis;cannabis use behavior;Centers of Research Excellence;Chronic;Clinical;clinically significant;Cognition;Collection;Communities;Complex;Consumption;coping;Coupling;critical period;Death Rate;Development;Diagnosis;Distress;Ecological momentary assessment;Emergency Department evaluation;emerging adult;endogenous cannabinoid system;experience;follow-up;Goals;Health;Heart Rate;high risk;Hospitals;Individual;injured;Injury;insight;Intensive Care;Interview;Laws;Legal;Licensing;Life;Link;Long-Term Effects;marijuana legalization;marijuana use;marijuana use disorder;marijuana user;Medical Marijuana;Mental Depression;Modeling;Monitor;negative affect;negative mood;Negative Reinforcements;Outcome;Output;Participant;Patient Admission;patient oriented;Patient Self-Report;Pattern;physical assault;Physiological;Physiology;Play;post-trauma;Post-Traumatic Stress Disorders;post-traumatic symptoms;prospective;Prospective Studies;Psychopathology;Qualifying;Recovery;recruit;reduce symptoms;Reporting;Research;response;Rhode Island;Risk;Role;Safety;Sampling;Self Medication;Severities;Sleep Disorders;Sleeplessness;smart watch;social relationships;Stress;stress symptom;substance misuse;substance use;Substance Use Disorder;symptom cluster;Symptoms;Therapeutic;Time;Trauma;trauma centers;trauma exposure;Trauma patient;Trauma recovery;trauma symptom;Traumatic injury;United States;Vehicle crash;wearable sensor technology;Withdrawal Symptom

PROJECT_TITLE: A prospective study of posttraumatic stress symptom development and cannabis use among trauma exposed injured emerging adults following Emergency Department discharge


NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Emergency Care;Health Services;Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation;Rural Health;Telehealth

PI_NAMEs: GOLDBERG, ELIZABETH  (contact)

PROJECT_TERMS: acceptability and feasibility;Accident and Emergency department;Acute;Age;Agreement;arm;behavior change;Calendar;care seeking;career;Caregivers;Caring;Centers of Research Excellence;Cessation of life;Clinical;Clinical Trials;Communities;Computer software;Consult;Consultations;Data;Data Analyses;Development;Devices;digital health;efficacy evaluation;Elderly;Electronic Health Record;Emergency Department patient;Emergency department visit;Emergency Medicine;equilibration disorder;Evaluation;Expenditure;fall injury;Fall prevention;fall risk;falls;Feasibility Studies;Feedback;Funding;Future;Gait abnormality;Geriatrics;Goals;Health;Health Care Visit;Home;Hospitalization;Hospitals;Impaired cognition;improved;Injury;insight;Institution;Interest Group;Intervention;Interview;Measures;Mentors;Methodology;Methods;Modeling;Motivation;Neurologist;Nurses;older adult;Participant;Patients;Peer Review;Persons;Pharmacists;pharmacy benefit;Pharmacy facility;physical therapist;Physicians;Population;practice setting;prevent;Prevention;preventive intervention;Primary Care Physician;primary care setting;Procedures;Process Measure;promoter;Protocols documentation;Qualitative Research;Quality of life;Randomized;Recommendation;recruit;Recurrence;Research;Review Literature;Rhode Island;Risk Assessment;Risk Factors;Rural;Rural Community;Sampling;Scientist;Services;Site;Specialist;Stroke;Structure;suburb;suburban communities;Suggestion;Technology;telehealth;Telephone;Testing;Time;uptake;Urban Community;virtual;Work;working group

PROJECT_TITLE: Expanding the Reach of a Fall Prevention Intervention for Older Adult Emergency Department Patients through Telehealth


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Health Services;Prevention;Primary Health Care;Uterine Cancer;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Endometrial cancer survivors are a rapidly growing population with complex healthcare needs. Coordination of care between oncologists, gynecologists, primary care physicians, and other specialists may help to ensure that survivors receive the appropriate healthcare services to improve their long-term health. Our study will investigate whether greater care coordination after endometrial cancer is associated with several critical health outcomes, and will inform the development of interventions that seek to enhance the delivery of survivorship care.

PI_NAMEs: ANDERSON, CHELSEA  (contact)

PROGRAM_OFFICER_NAME: WEAVER, SALLIE JAYNE

PROJECT_TERMS: Adherence;Aftercare;Breast Cancer survivor;Cancer Detection;cancer diagnosis;cancer recurrence;Cancer Survivor;cancer survivorship care;cancer therapy;Cardiovascular Diagnostic Techniques;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;care coordination;care fragmentation;Caring;Cause of Death;Characteristics;Chronic;Colorectal Cancer;Complex;Data;data resource;Data Sources;demographics;design;Detection;Development;Disease;Early Diagnosis;Emergency department visit;Endometrial;Endometrial Carcinoma;Ensure;Failure;follow-up;Guidelines;Gynecologic;Gynecologic Oncologist;Gynecologic Oncology;Gynecologist;Health;health care delivery;health care service;Healthcare;high risk;Histology;Hospitalization;hospitalization rates;improved;Intervention;Link;Long-Term Survivors;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Medical;Medicare;Modeling;Newly Diagnosed;novel;Obesity;older women;Oncologist;Outcome;Patient Care;Patient-Focused Outcomes;Patients;Pattern;Periodicals;Physical Examination;Physicians;poor health outcome;Population;prevent;Prevention;Preventive care;Primary Care Physician;Provider;provider communication;Quality of Care;Recommendation;Recording of previous events;Research;Risk;Risk Factors;risk sharing;Role;SEER Program;side effect;Societies;Specialist;Subgroup;Survivors;survivorship;Symptoms;Testing;therapy development;Time;urban area;Variant;Visit;Woman;women's treatment

PROJECT_TITLE: Claims-based measures of care coordination and long-term health among older women with endometrial cancer


ORG_CITY: NEW YORK

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative Intravenous lipid emulsions (ILEs) are an antidote to local anesthetic systemic toxicity (LAST), a life-threatening syndrome caused by anesthetic overdose that often presents as seizures and cardiovascular instability. Intralipid®, the prototypical ILE of long-chain triglycerides derived from soybean oil, and other emulsions reverse local anesthetic-induced mitochondrial dysfunction in cardiac models, but this mechanism has not been explored in the context of central nervous system dysfunction. My preliminary data demonstrates surprisingly that Intralipid® can power neuronal synaptic function in the absence of glucose, and my proposal will systematically investigate the metabolic effects of ILE components to identify the mixture most capable of reversing neurotoxicity in vitro and in vivo.

PI_NAMEs: COOK, DANIEL CHARLES (contact)

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TERMS: Action Potentials;Adenosine Triphosphate;Agreement;Anesthetics;Antidotes;aqueous;Belief;Biosensor;Brain;Bypass;Calcium;Cardiac;Cardiotoxicity;Cardiovascular system;career;Carnitine;Central Nervous System;Cephalic;Clinical;clinical application;comparative efficacy;Convulsants;Data;deprivation;design;Dose;Effectiveness;Emulsions;Environment;excitatory neuron;falls;Fat emulsion;Flavins;Formulation;Functional disorder;Funding;Glucose;glucose metabolism;Glycolysis;Glycolysis Inhibition;Guidelines;Heart Arrest;Hypoglycemia;ICAM3 gene;Image;Impairment;improved;In Vitro;in vivo;inhibitory neuron;Institution;Intravenous Fat Emulsions;Investigation;Ischemia;knock-down;Length;Lidocaine;Life;lipid transport;Lipids;lipoprotein lipase;Local Anesthetics;Measurement;Measures;Mediating;Medical;Medicine;Medium chain triglycerides;Mentors;Metabolic;metabolic imaging;Metabolic stress;Metabolism;mitochondrial dysfunction;Mitochondrial Proteins;Modeling;Molecular;Molecular Target;Mus;Muscle;Nerve;Neurobiology;Neurologic;Neurons;Neuropharmacology;neurotoxic;neurotoxicity;neurotransmission;Nonesterified Fatty Acids;optical imaging;Optical reporter;Overdose;oxidation;Oxidative Phosphorylation;Parenteral Nutrition;Pathway interactions;Perfusion;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;Phospholipids;prevent;Prevention;Production;Publications;Pyruvate;Recommendation;Recycling;Research;Research Proposals;Resuscitation;Role;Seizures;Site;small hairpin RNA;Sodium Channel;Soybean Oil;Symptoms;Synapses;synaptic function;Synaptic Vesicles;Syndrome;systemic toxicity;Testing;Therapeutic;Toxic effect;Triglycerides;voltage

PROJECT_TITLE: Metabolic impact of Intralipid on synaptic function as a mechanism of resuscitation in local anesthetic systemic toxicity

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Emergency Care;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Physical Injury - Accidents and Adverse Effects;Social Determinants of Health;Unintentional Childhood Injury;Violence Research;Youth Violence

PI_NAMEs: RUEST, STEPHANIE  (contact)

PROJECT_TERMS: 5 year old;Accident and Emergency department;Accounting;Affect;Calibration;Centers of Research Excellence;Characteristics;Child;Child Abuse;Child Abuse and Neglect;Child Development;child protection;Childhood;Childhood Injury;Clinical;Clinical Data;clinical decision-making;clinical predictors;cohort;Complex;Databases;Decision Trees;deep neural network;demographics;Derivation procedure;design;Detection;Development;Diagnosis;disparity reduction;Electronic Health Record;Emergency Care;Emotional;Evaluation;explicit bias;Family;Follow-Up Studies;Fracture;Frequencies;Generations;Goals;gradient boosting;high risk;Hospitals;implicit bias;improved;Injury;Institution;Investigation;Literature;Machine Learning;Methodology;Methods;Modeling;Multicenter Studies;Natural Language Processing;Outcome;Patient Admission;patient health information;Patients;Pattern;Pediatric Hospitals;Population;programs;prospective;Provider;Public Health;radiological imaging;Radiology Specialty;Recording of previous events;Recurrence;Reference Standards;Registries;Reporting;Rhode Island;Risk Assessment;Skin Tissue;sociodemographic factors;sociodemographics;Soft Tissue Injuries;Specialist;Specificity;statistics;Structure;Techniques;Text;Time;tool;Training;Trauma;Validation

PROJECT_TITLE: Derivation of a Clinical Prediction Rule for Pediatric Abusive Fractures


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

ORG_STATE: CA

PHR: Modified Public Health Relevance  Prediabetes and type 2 diabetes result from progressive dysfunction of pancreatic endocrine beta cells; we have identified a secreted factor made in the exocrine pancreas that can protect against the loss of beta cell function. In this proposal, we focus on revealing new mechanisms involved in beta cell function. Understanding how this secreted factor carry out its protective role in beta cells will inform on how best to target it for diabetes prevention/treatment.

PI_NAMEs: FUEGER, PATRICK T.;KU, HSUN TERESA (contact);THURMOND, DEBBIE C

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: 1 year old;Address;Adult;Affect;aged;American;Bacteria;Beta Cell;Biological Models;Birth;blood glucose regulation;Brain;Cell Communication;Cell Physiology;cell type;Cells;Child;Chronic Disease;Cities;Closure by clamp;Compensation;Complex;Cysteine;Data;Defect;Development;Diabetes Mellitus;diabetes pathogenesis;Diabetes prevention;diabetogenic;Disease;Disulfides;Ductal Epithelial Cell;Eating;Embryo;endocrine pancreas development;Environment;Epithelial Cells;epithelial repair;Epithelium;Exhibits;Exocrine pancreas;Extracellular Matrix Proteins;Family;Functional disorder;Gastrointestinal tract structure;Gel;Glucose Intolerance;Goals;Human;human tissue;Hyperglycemia;Impairment;In Vitro;in vitro Model;in vivo;Incidence;Infiltration;Injury;innovation;Institution;Insulin;insulin secretion;insulin sensitivity;Intervention;islet;Islet Cell;Islets of Langerhans;knock-down;knockout gene;Knockout Mice;Knowledge;Lung;Lymphoid Tissue;Metabolic;Molecular;mouse model;Mucins;Mucous body substance;Mus;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Obesity;old mice;older adult;Organ;overexpression;Palmitic Acids;Pancreas;Parasites;Pathogenesis;Pattern;Peptide Hydrolases;Peptides;Peripheral;Personal Satisfaction;Play;Population;Prediabetes syndrome;prevent;Prevention;Protein Family;Protein Secretion;Proteins;Proteomics;public health relevance;receptor;Research;Resistance;response;Rodent;Role;Stimulus;Stress;Teenagers;Testing;TFF1 gene;Thick;Thyroid Gland;Tissues;tool;Translations;trefoil factor;United States;Virus;western diet;Work;young adult

PROJECT_TITLE: Role of trefoil factor family proteins in beta cell function.


NIH_SPENDING_CATS: Bioengineering

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Metabolism of nutrients is misregulated in many diseases, including cancer. Certain metabolic pathways appear to sense the flow of nutrients through the pathway, or flux, instead of the concentration of nutrients, but the mechanism of this has been unclear. This project will investigate a novel potential mechanism for sensing metabolic flux, potentially leading to the identification of new targets for treating metabolic misregulation.

PI_NAMEs: SPRINGER, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Affect;Amino Acyl-tRNA Synthetases;Bacteria;Behavior;Binding;Biochemical;Biological Assay;Biological Models;Carbon;Catalysis;Cells;Complex;Computer Models;Coupled;Data;Disease;Dissection;Elements;enzyme substrate complex;Enzymes;Escherichia coli;Eukaryota;experimental study;extracellular;Feedback;galactokinase;Galactose;Galectin 1;Genetic;Glutamine;Glycolysis;Human;insight;Kinetics;leucine-tRNA;Literature;Malignant Neoplasms;Measurement;Measures;Metabolic;Metabolic Pathway;Metabolism;Methods;Modality;Modeling;Molecular Conformation;mutant;new therapeutic target;Nitrogen;novel;Nutrient;nutrient metabolism;Pathway interactions;Phenotype;Physiological;Process;Property;receptor;Regulation;response;Role;Saccharomyces cerevisiae;sensor;Signal Pathway;Signal Transduction;Signaling Molecule;Signaling Protein;single cell technology;Stimulus;synergism;System;Testing;Titrations;tool;Translations;Up-Regulation;uptake;whole genome;Work;Yeasts

PROJECT_TITLE: A novel and simple mechanism by which cells can sense enzymatic flux

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Bioengineering;Genetics;Machine Learning and Artificial Intelligence

PHR: Project Narrative Researchers have discovered new types of cells, called “senescent cells”, that are suspected to be involved in aging. We plan to use novel technologies we developed to find out how these cells develop, how they damage normal tissues, and how to kill them.

PI_NAMEs: KIRSCHNER, MARC WALLACE (contact);PESHKIN, LEON

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Address;Affect;Age;Aging;aging process;aging related disease;Animals;Biochemical;Biological Assay;Cell Aging;Cell Culture Techniques;Cell Cycle;Cell Cycle Arrest;cell growth;Cell Line;Cell Senescence Induction;Cell Size;Cell Survival;cell type;Cells;Cellular biology;Cessation of life;chemokine;Clustered Regularly Interspaced Short Palindromic Repeats;Critical Pathways;Cultured Cells;Dasatinib;Dependence;Development;DNA Damage;Dryness;Event;experimental study;Exposure to;FRAP1 gene;Genes;Goals;Growth;Growth Factor;healthspan;Hepatocyte;Heterogeneity;Hormones;Human;Hydrogen Peroxide;Hypertrophy;Inflammatory;insight;Insulin;interest;Ionizing radiation;kinase inhibitor;Kinetics;knock-down;Laboratories;Learning;Life;Lipids;Liver;Logic;Machine Learning;Mass Spectrum Analysis;Measures;Methods;Microscopic;Microscopy;Molecular;mTOR inhibition;Mus;Mutagenesis;new technology;Normal Cell;Normal tissue morphology;novel therapeutics;old mice;Oncogene Activation;Pathology;Pathway interactions;Pattern;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Pharmacology;Phenotype;Phosphoproteins;phosphoproteomics;Phosphorylated Peptide;Phosphorylation;Phosphorylation Site;Phosphotransferases;Physiological;prevent;programs;Proteins;Proteomics;proteostasis;Radiation;Reactive Oxygen Species;Research Personnel;response;Reverse engineering;Role;senescence;senescent cell;senolytics;senomorphic;Signal Transduction;Sirolimus;Site;Small Interfering RNA;Stress;stressor;Swelling;Symptoms;Testing;Time;Tissues;tool

PROJECT_TITLE: Reverse Engineering of Cell Senescence

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: PROJECT NARRATIVE Cellular metabolism allows cells to grow, develop, repair damage, and respond to environmental changes, which is fundamental to life. Altered cellular metabolism contributes to the pathogenesis of many common diseases, such as cardiovascular disease, cancer, diabetes, and autoimmune disorders, which are prevalent in Oklahoma. This Center for Cellular Metabolism Research in Oklahoma (CMRO) Phase I COBRE will create and nurture excellence in cellular metabolism in Oklahoma.

PI_NAMEs: XIA, LIJUN  (contact)

PROJECT_TERMS: Address;Aging;Area;Arthritis;Autoimmune Diseases;Biological Models;Biology;Biomedical Research;Cardiovascular Diseases;Cardiovascular system;career;cell growth;Cells;Centers of Research Excellence;Clinical Immunology;collaborative environment;Core Facility;Development;Diabetes Mellitus;Disease;Environment;environmental change;Equipment;experience;Faculty;Fostering;Foundations;Funding;Goals;Growth;Health;Human Resources;Infrastructure;Interdisciplinary Study;interest;Leadership;Life;Malignant Neoplasms;Medical Research;member;Mentors;Metabolism;multidisciplinary;novel;Oklahoma;Pathogenesis;Phase;professor;programs;Records;recruit;repaired;Research;Research Infrastructure;Research Institute;Research Personnel;Resources;Scientist;Secure;success;Technology;tenure track;Training;Universities;Work


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Address;Advisory Committees;Area;Biomedical Research;career;Centers of Research Excellence;Communication;Core Facility;data sharing;Ensure;Faculty;Fostering;Foundations;Goals;Growth;Heart;Infrastructure;interdisciplinary approach;Medical Research;member;Mentors;Metabolic;Metabolism;multidisciplinary;Oklahoma;Phase;Pilot Projects;Privatization;programs;recruit;Research;Research Institute;Research Peer Review;Research Personnel;Research Project Grants;Resources;support network;United States National Institutes of Health


NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Osteoporosis;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Relevance to Public Health: Impaired bone repair is a major public health burden. There are over 12 million fractures per year in the U.S., with up to 10% having impaired healing, resulting in substantial patient morbidity and societal costs. This research will identify genes that regulate intramembranous bone regeneration. The results of this project have the potential to lead to a novel treatment for this common disorder.

PI_NAMEs: FARBER, CHARLES R (contact);SUMNER, D RICK

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Ablation;Academic Medical Centers;Address;Affect;Bayesian Network;Bilateral;Biological Process;bone;Bone Density;bone fracture repair;bone lead;Bone neoplasms;Bone Regeneration;bone repair;Candidate Disease Gene;candidate identification;causal variant;cell type;Cells;Chicago;common treatment;Complex;Data;Defect;Dental Care;Dental Implants;design;Disease;Distraction Osteogenesis;diverse data;Event;Excision;experimental study;Femur;Fracture;gene discovery;gene network;Genes;Genetic;genetic analysis;genetic approach;Genetic study;genetic variant;Genetic Variation;Genome;genome wide association study;Genotype;Heritability;Heterozygote;Impaired healing;Impairment;improved;In Vitro;in vivo;indexing;Inflammation;Injury;innovation;intramembranous bone;Knock-out;Knockout Mice;Knowledge;long bone;Maps;Marrow;Measures;Mechanics;mesenchymal stromal cell;model organism;Molecular;Morbidity - disease rate;mouse model;Mus;Network-based;new therapeutic target;novel;Orthopedic Procedures;Orthopedics;osteogenic;Osteoporosis;participant enrollment;Pathway interactions;Patients;periostin;Phenotype;Population;Public Health;Quantitative Trait Loci;Regenerative response;repaired;Research;Role;sample fixation;Single Nucleotide Polymorphism;single-cell RNA sequencing;skeletal;Skeleton;societal costs;Stress Fractures;System;targeted treatment;Testing;Therapeutic Intervention;therapeutic target;Tissues;tomography;trait;transcriptomics;Trauma;Universities;Virginia

PROJECT_TITLE: Systems Genetics of Bone Regeneration

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Genetics;Neurosciences

PHR: Project Narrative Osteocytes serve as the major orchestrator of skeletal metabolism and many pathologic or disease conditions can now be ascribed to disrupted osteocyte functions. This proposal describes an innovative and comprehensive approach to investigate the osteocytic role of the transcription factor SP7. Ultimately, the long-term goal of this study is to determine not only how osteocyte-enriched genes function in bone disease, but also to enable the development of next generation therapeutics for skeletal diseases that target osteocyte development.

PI_NAMEs: WANG, JIALIANG  (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Acceleration;Address;Affect;Applications Grants;Award;Bioinformatics;Biology;bone;Bone Development;Bone Diseases;bone health;Bone Resorption;Brain;career;Cell Culture Techniques;Cell Surface Extensions;cell type;Cells;Communication;Complex;Data;Dendrites;Development;Disease;Ensure;Etiology;Faculty;Future;gene function;gene regulatory network;Genes;Genetic;Genetic Transcription;genome wide association study;Goals;Grant;Homeostasis;Human;Human Characteristics;In Vitro;in vitro testing;in vivo;innovation;interdisciplinary collaboration;Investigation;Knowledge;Lasers;Link;Mentorship;Metabolism;Methods;Microdissection;Modeling;Molecular;mouse model;Mus;Mutation;Neurons;neuropeptide Y;Neurosciences Research;novel;novel therapeutics;osteoblast differentiation;Osteoblasts;Osteocytes;Osteogenesis;Osteogenesis Imperfecta;Osteoporosis;Pathologic;Pathway interactions;Patients;Pattern;Phase;Phenotype;Positioning Attribute;Process;programs;Publications;Regulation;Regulatory Element;Research Personnel;Role;Signal Pathway;single-cell RNA sequencing;skeletal;skeletal abnormality;skeletal disorder;targeted treatment;tenure track;Training;transcription factor;transcriptome;transcriptomic profiling;transcriptomics;Transgenic Mice;Variant;Work

PROJECT_TITLE: Comprehensive investigation of SP7 during the osteoblast-to-osteocyte transition

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


PI_NAMEs: ALBEROLA-ILA, JOSE  (contact)

PROJECT_TERMS: Antibodies;Area;Biological Assay;Biology;Calcium Signaling;Cardiovascular system;Cell Cycle;cell growth;Cell Separation;Cell surface;Cells;Centers of Research Excellence;Core Facility;design;Developmental Biology;experimental study;Flow Cytometry;Foundations;glucose uptake;Goals;Health;Immunology;instrument;instrumentation;Label;Medical Research;Metabolism;Mitochondria;novel;Oklahoma;Phenotype;Population;programs;Research;Research Personnel;Sorting;Technology;tool

PROJECT_TITLE: Flow Cytometry Core


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative  Cardiovascular disease is the leading cause of mortality in United States and causes more deaths than all cancers combined. Although cardiac ischemia is inexplicably tied to acid-base regulation and Cl- homeostasis in the heart, the mechanism remains incompletely understood. This proposal aims to reveal a missing molecular link between Cl- homeostasis and acid-base regulation in the heart. 1

PI_NAMEs: ZHANG, XIAO-DONG  (contact)

PROJECT_TERMS: Ablation;Acids;Action Potentials;Affect;Anions;antiporter;Arrhythmia;base;Bicarbonates;Biochemical;Buffers;Cardiac;Cardiac Myocytes;cardioprotection;Cardiovascular Diseases;Cations;Cell Physiology;Cells;Cessation of life;Chlorides;confocal imaging;Conscious;Coronary heart disease;Coupled;Data;design;Disease;dynamic system;EKG QRS Complex;Electrocardiogram;Electrophysiology (science);experimental study;Family;Frequencies;Generations;genetic approach;Goals;Health;Heart;Heart Atrium;Heart Diseases;heart function;Homeostasis;Human;Human Cloning;Image;Impairment;in vivo;insight;interdisciplinary approach;Ischemia;Knockout Mice;Link;Malignant Neoplasms;Mechanics;Mediating;member;Microscopy;Molecular;mortality;Motivation;mouse model;multimodality;Mus;Muscle Cells;Myocardial Infarction;Myocardial Ischemia;Myocardium;new therapeutic target;novel;Pacemakers;Pathologic;Physiological;Play;Protein Isoforms;Reagent;Regulation;Reperfusion Injury;Reperfusion Therapy;Reporting;Role;second harmonic;Signal Transduction;Sinus Bradycardia;Skeletal Muscle;solute;symporter;System;Techniques;Telemetry;Testing;Therapeutic;Transcript;United States;Ventricular

PROJECT_TITLE: Cardiac chloride and pH regulation in health and disease

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Depression;Genetics;Mental Health;Mental Illness

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

PHR: Project Narrative The development of statistical methods to account and assess for differences in genetic association studies of depression by sex has the potential to lead to improved treatments, thereby improving public health.

PI_NAMEs: LUTZ, SHARON MARIE (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: 18 year old;addiction;Adult;Affect;Age;Area;biobank;Biological;clinical phenotype;Communities;Complex;Computer software;Data;deep learning;Development;disability;Disease;Disease-Free Survival;disorder risk;Etiology;Event;Generalized Anxiety Disorder;Genes;Genetic;genetic association;genetic variant;genome wide association study;Goals;Grant;Heterogeneity;improved;lifetime risk;Linkage Disequilibrium;Machine Learning;Major Depressive Disorder;men;Mental Depression;Mental disorders;Mental Health;method development;Methods;Modeling;Morbidity - disease rate;novel;novel strategies;Outcome;Participant;personalized medicine;Pharmacotherapy;Phenotype;polygenic risk score;population based;population health;Public Health;Research Personnel;Resources;Role;semiparametric;sex;Sex Differences;simulation;Single Nucleotide Polymorphism;Statistical Methods;statistics;Structure;Testing;Time;user friendly software;Validation;Woman;women versus men;Work

PROJECT_TITLE: The role of sex in genetic association studies of depression

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding

PI_NAMEs: GRIFFIN, TIMOTHY M (contact)

PROJECT_TERMS: Address;Advisory Committees;Aging;analytical method;Area;Autoimmune Diseases;Bioinformatics;Biological;Biological Assay;Cardiovascular Diseases;Cell Respiration;Cells;Cellular Metabolic Process;Centers of Research Excellence;Clinical Trials;comparative;Complex;Consultations;Data;Data Analyses;Decision Making;Degenerative polyarthritis;design;Development;Diet;Disease;Doctor of Philosophy;Ensure;Environment;Equipment;Evaluation;exercise intervention;experience;Experimental Designs;follow-up;Fostering;Functional disorder;Funding;Future;Genus Hippocampus;Goals;Growth;in vivo;instrument;instrumentation;Interdisciplinary Study;interest;Isotopes;Leadership;Malignant Neoplasms;Mass Fragmentography;Measurement;Mediating;meetings;member;Mentors;Mentorship;Metabolic;metabolic abnormality assessment;metabolic phenotype;Metabolism;Metformin;Methodology;Methods;Mitochondria;Modeling;mouse development;multidisciplinary;Mus;new technology;novel;Obese Mice;Oklahoma;operation;Pathology;Phase;Physiology;Positioning Attribute;Procedures;Process;programs;protein degradation;Regulation;Research;Research Design;Research Personnel;Research Support;Resources;Role;Services;skills;stable isotope;Standardization;Structure;sustainable resource;Technical Expertise;Techniques;Tissues;Tracer;Training

PROJECT_TITLE: Metabolic Phenotyping Core


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Liver Disease;Nutrition

ORG_CITY: SAINT LOUIS

ORG_DEPT: PEDIATRICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Fasting and caloric restriction are effective to treat patients with pre-diabetes or non-alcoholic fatty liver disease (NAFLD), but intensive lifestyle changes are difficult for many to implement and sustain. We discovered a key pathway in the liver, which is activated during fasting, and which is sufficient to treat pre- diabetes and NAFLD in mice. In this proposal, we will define how Arg2 mediates its effects, and examine bring forth new therapies that mimic the actions of Arg2 to ultimately treat obesity-related metabolic disease.

PI_NAMEs: DEBOSCH, BRIAN JESSE (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Amino Acids;ARG2 gene;arginase;Arginine;Arginine deiminase;Attenuated;Autophagocytosis;Biological Response Modifier Therapy;Biology;Caloric Restriction;Cardiovascular system;Cells;Clinical;clinically significant;Complex;Data;deprivation;Diabetes Mellitus;Diabetic mouse;Diet;disease model;effective therapy;efficacy evaluation;Energy Metabolism;Enzymes;Fasting;fasting glucose;Fatty acid glycerol esters;Fatty Liver;feeding;Genetic;Genetic Models;Glucose;glucose transport;Goals;Hepatic;Hepatocyte;Homeostasis;Human;Hydrolase;improved;In Vitro;in vitro activity;in vivo;Inflammation;Inflammatory;Insulin Resistance;insulin sensitivity;Intermittent fasting;Life Style;Life Style Modification;Link;Lipids;Liver;Liver Fibrosis;liver inflammation;loss of function;Machine Learning;Mediating;Metabolic;Metabolic Diseases;metabolomics;Molecular;mortality;mouse model;Mus;mutant;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;NOS2A gene;novel;novel therapeutics;Obesity;Outcome;overexpression;Overnutrition;Pathway interactions;Patients;Peripheral;Persons;Pharmaceutical Preparations;pharmacologic;Physiological;Prediabetes syndrome;Preparation;response;screening;Signal Transduction;Site;small molecule;Testing;Therapeutic;Therapeutic Effect;Tissues;transcriptomics;Translating

PROJECT_TITLE: Leveraging arginase biology against metabolic disease


NIH_SPENDING_CATS: Genetics;Human Genome;Lung;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE The proposal will provide critically-needed insight into the cell types responsible for repair and maintenance of distal mouse and human lung. Using several state of the art techniques, we will identify the course of differentiation of distal lung epithelial progenitors to reveal progenitor identities and signaling pathways involved in regenerative response to injury. Knowledge gained through this study will clarify failed regenerative pathways in chronic lung diseases and aid in developing novel therapies and treatments for patients.

PI_NAMEs: KATHIRIYA, JAYMIN J (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Acute;Adult;airway epithelium;Alveolar;Alveolar Cell;alveolar epithelium;Alveolus;Basal Cell;Biological Assay;Bleomycin;Cell surface;cell type;Cells;Characteristics;Chromatin;Chronic lung disease;Coculture Techniques;Complex;Cues;Data;Disease;Disease Outcome;Distal;DNA;Epithelial Cells;epithelial stem cell;Epithelium;epithelium regeneration;Fellowship;fibrotic lung;fibrotic lung disease;Foundations;Gene Expression;Genes;genome-wide analysis;Human;Immunocompromised Host;improved;In Situ;In Vitro;in vivo;Inflammatory;Influenza;injured;Injury;insight;Knowledge;Location;Lung;Lung Capacity;lung injury;lung regeneration;lung repair;Maintenance;Major Histocompatibility Complex;Major Histocompatibility Complex Gene;Measures;Mesenchymal;Messenger RNA;Mus;Natural regeneration;novel;novel therapeutics;NRG1 gene;Organoids;Patients;Pattern;Population;Process;progenitor;Proliferating;Proteins;pulmonary function;reconstitution;Recovery;regenerative;Regenerative capacity;Regenerative pathway;Regenerative research;Regenerative response;Regulation;repaired;response to injury;RNA;Role;Secretory Cell;severe injury;Severities;Signal Pathway;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Slice;Source;Spatial Distribution;stem;stem cell biomarkers;Stem cell transplant;stem cells;Techniques;Testing;Tissues;transcriptome;Transplantation

PROJECT_TITLE: Sources and Regulation of Epithelial Stem/Progenitor Cells in Alveolar Regeneration

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


PHR: PROJECT NARRATIVE Asthma is a major public health problem in American children, but effective strategies to prevent the development of childhood asthma are not yet available. In an ongoing, diverse cohort of U.S. children (53% African-American or Hispanic) with a history of severe bronchiolitis, the investigators will elucidate the mechanisms of developing asthma and define subtypes (endotypes) by integrating genome, metabolome, and microbiome data. This research aims to identify novel approaches for primary prevention of childhood asthma.

PI_NAMEs: ZHU, ZHAOZHONG  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: 6 year old;African American;Age;airway inflammation;Allergic Disease;American;Asthma;asthma prevention;Blood;Blood specimen;Bronchiolitis;CCL7 gene;Child;Childhood;Childhood Asthma;Chronic;Clinical;clinical phenotype;clinically relevant;cohort;Cohort Studies;Collaborations;cytokine;Data;Development;Diagnosis;early childhood;Enrollment;Environmental Epidemiology;eosinophil;epidemiology study;Ethnic Origin;evidence base;follow-up;Funding;Genetic;genetic epidemiology;Genetic Risk;genetic variant;Genome;genome wide association study;genomic locus;Genomics;Geography;gut microbiota;high risk;Hispanic;Hospitalization;IgE;IL17 gene;Immune;Immunologics;indexing;infancy;Infant;Inflammatory;innovation;International;Interview;Knowledge;Lead;Learning;Measurement;Medical Records;Mentors;Metabolic;Metabolism;metabolome;metabolomics;metagenomic sequencing;Methods;microbiome;Mission;Moraxella;Morbidity - disease rate;Multiomic Data;Nasopharynx;National Institute of Allergy and Infectious Disease;novel;novel strategies;Parents;Participant;Pathogenesis;Pathway interactions;Persons;Phenotype;Play;Population;Population Attributable Risks;Positioning Attribute;prevent;Prevention strategy;Primary Prevention;Process;Prospective, cohort study;Public Health;Race;Recording of previous events;Research;Research Personnel;respiratory;respiratory microbiome;respiratory microbiota;Risk;Risk Factors;risk variant;Role;rRNA Genes;Sampling;Serum;Severities;skills;Sphingolipids;Spirometry;Strategic Planning;Structure;Testing;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Integrating the genome, metabolome, and microbiome for childhood asthma: Risk and endotypes

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Infectious Diseases;Nanotechnology;Wound Healing and Care

ORG_CITY: KENT

ORG_NAME: KENT STATE UNIVERSITY

PHR: NARRATIVE Skin and soft tissue infections (SSTIs) are used to be readily treatable bacterial infections with the over-the-counter topical antimicrobial creams. With the emergence of both hospital- and community-associated methicillin-resistant Staphylococcus aureus (MRSA; the so-called “superbug”) and multidrug-resistant Pseudomonas aeruginosa (MDPA), SSTIs can be serious and life-threatening because these bacteria are invasive and toxigenic. We propose to develop a broad-spectrum topical antimicrobial cream based on bismuth oxide (Bi2O3) nanoparticles to combat SSTIs caused by multidrug-resistant bacteria.

PI_NAMEs: HUANG, SONGPING D (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Anti-Bacterial Agents;Antibiotic Therapy;Antibiotics;antimicrobial;Bacitracin;Bacteria;Bacterial Infections;base;Bismuth;burn therapy;Caring;Ciprofloxacin;Clinical;Collaborations;combat;Communities;Coupled;Cream;delivery vehicle;Development;Drug Delivery Systems;Drug Prescriptions;Drug resistance;drug resistance development;Drug resistant Pseudomonas aeruginosa;drug-sensitive;Effectiveness;effectiveness study;Environmental Wind;Evaluation Studies;experience;Fluoroquinolones;Formulation;Foundations;Fusidic Acid;help-seeking behavior;Hospitals;improved;In Vitro;in vivo;Infectious Skin Diseases;Injectable;Life;Medical;Meropenem;Methicillin Resistance;methicillin resistant Staphylococcus aureus;methicillin susceptible Staphylococcus aureus;Minor;multidrug-resistant Pseudomonas aeruginosa;Multiple Bacterial Drug Resistance;Mupirocin;nanomaterials;nanoparticle;Neomycin;Ointments;Oral;Oxides;Penetration;Persons;Pharmaceutical Preparations;Play;Polymyxin B;Preparation;prevent;prophylactic;Research;Research Project Grants;Resistance;response;Role;Skin;Skin injury;Soft Tissue Infections;Staphylococcus aureus;success;Superbug;Systemic infection;Techniques;Time;topical anti-microbial;Topical Antibiotic;Treatment outcome;Wound Infection

PROJECT_TITLE: A broad-spectrum antimicrobial ointment containing Bi2O3 NPs for skin and soft tissue infections by multidrug-resistant bacteria

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative University of Utah Health will offer the Utah Stimulating Access to Research in Residency (Utah StARR) R38 Program to resident-investigators from six residency programs including Family Medicine, Internal Medicine, Neurology, Medicine-Pediatrics, Obstetrics and Gynecology, and Pediatrics with the goal of transitioning resident-investigators to successful careers as clinician-investigators to conduct clinical, translational, community-engaged, and/or health services research. Trainees will be provided didactic coursework in research methods, leadership training and career development, and extensive mentoring throughout the program. The proposed outcome of the research training program is to increase the number of resident- investigators from primary-care serving and related specialties engaged in research aimed at reducing health disparities in cardiovascular, pulmonary, and related diseases impacting disadvantaged populations.

PI_NAMEs: CONROY, MARGARET B (contact);STANFORD, JOSEPH BARNEY

PROJECT_TERMS: Achievement;Address;Admission activity;Age;Applications Grants;Award;Cardiovascular Diseases;career;career development;Characteristics;Clinical;clinical practice;Clinical Research;Clinical Sciences;Communities;community engaged research;COVID-19;Dedications;Department chair;Discipline of obstetrics;Disease;Disparity population;Education;Educational Curriculum;Enrollment;Ensure;Ethnic Origin;Evaluation;experience;Faculty;faculty mentor;faculty research;Family Practice;Fostering;Funding;Funding Agency;Future;Gender;Geography;Goals;Grant;Gynecology;Health;health difference;Health Services Research;Health system;Heart Diseases;Hematological Disease;Immigration;Income;Individual;Infrastructure;Institution;interest;Internal Medicine;investigator training;Knowledge Discovery;Leadership;learning progression;Lung Diseases;Manuscripts;Medical;medical specialties;Medicine;Mentors;Mission;National Heart, Lung, and Blood Institute;Neurology;Outcome;outcome disparities;Outcomes Research;Pediatrics;Physicians;Population;Positioning Attribute;Prevention;Preventive Medicine;Primary Care;programs;Publications;Race;Recording of previous events;recruit;Reduce health disparities;Research;research and development;Research Methodology;Research Personnel;Research Project Grants;Research Training;Residencies;Scholars Program;Scientist;Seasons;Services;Sex Orientation;Sleep Disorders;Strategic vision;success;Targeted Research;Time;Training;Training Programs;Translational Research;United States National Institutes of Health;Universities;Utah;Writing


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE Drug development for autism is limited by our lack of understanding of how genes that contribute to autism risk function as members of complex signaling networks. Here, we investigate how autism genes alter signaling in three mouse models of autism using the network biology of protein interactions. We test hypothesis-driven strategies to correct ASD-linked signaling deficits and ask if treatment normalizes neuron function and behavior in mouse models.

PI_NAMEs: SMITH, STEPHEN EDWARD PAUCHA (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Affect;Agonist;autism spectrum disorder;Autopsy;Award;Bathing;Behavior;Behavioral Assay;behavioral phenotyping;Biological;Biology;Cellular Assay;Characteristics;Co-Immunoprecipitations;Complex;Data;Development;Disease;DNA Sequence Alteration;drug candidate;drug development;Electroencephalography;Electrophysiology (science);Equilibrium;Event;experimental study;eyeblink conditioning;Feedback;FRAP1 gene;FYN gene;Gene Expression;Gene Mutation;gene product;Genes;Genetic;genetic risk factor;Genome;Glutamate Receptor;Glutamates;Grant;Homeostasis;Human;Hyperactivity;In Vitro;in vivo;information model;information processing;inhibitor;Investigation;Link;mature animal;Measures;Mediating;member;Membrane;model of autism spectrum disorder;Modeling;Molecular;molecular phenotype;mouse genetics;mouse model;mTOR inhibition;mTOR Inhibitor;mTOR protein;Mus;Mutation;Neurodevelopmental Disorder;Neurons;neurotransmission;novel;novel therapeutics;Pathology;Pathway interactions;Patients;Pattern;pharmacologic;Phase;Phenotype;Phosphotransferases;PI3K/AKT;Productivity;Protein Biosynthesis;Protein Dynamics;Proteins;receptor;response;Risk;risk variant;scaffold;Scaffolding Protein;Signal Transduction;stem;Stimulus;Synapses;Synaptic plasticity;Synaptic Transmission;System;Testing;Vibrissae

PROJECT_TITLE: Investigating the synaptic pathology of Autism


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

PI_NAMEs: BIENIASZ, MAGDALENA  (contact)

PROJECT_TERMS: anaerobic glycolysis;Biological Assay;Biological Markers;Biology;cancer cell;Cancer cell line;Cancer Patient;cancer recurrence;cancer therapy;Cell Proliferation;Cell Reprogramming;Cells;Chemoresistance;chemotherapy;Cisplatin;cytotoxicity;Data;Death Rate;DNA biosynthesis;Effectiveness;Energy Metabolism;Enzymes;Evaluation;Fumarates;Generations;Genus Hippocampus;Glycolysis;Goals;Growth;Impairment;improved;in vivo evaluation;innovation;inorganic phosphate;instrument;knock-down;Malignant neoplasm of ovary;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Metabolic;Metabolic Pathway;Metabolism;Mitochondria;mortality;NADP;neoplastic cell;novel;novel therapeutic intervention;nucleic acid biosynthesis;Oklahoma;ovarian neoplasm;overexpression;Oxidation-Reduction;Oxidative Phosphorylation;Oxygen Consumption;Paclitaxel;Pathway interactions;patient derived xenograft model;patient response;Patient Selection;Patients;Pentosephosphate Pathway;precision medicine;programs;Proliferating;protein expression;Pyruvate;pyruvate carrier;Reactive Oxygen Species;Regulation;Research;Respiration;response;Role;small molecule inhibitor;Spirometry;Succinate Dehydrogenase;Succinates;System;Technology;Testing;The Cancer Genome Atlas;Tracer;treatment response;tumor;Tumor Biology;tumor growth;tumor metabolism;Up-Regulation;Warburg Effect

PROJECT_TITLE: Role of succinate dehydrogenase in ovarian cancer metabolism


ADMINISTERING_IC: HD

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Genetics;Human Genome;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The usage of different transcription start sites (TSSs) is a fundamental way of gene regulation that can lead to different protein products with distinct function and stability or different transcripts with different regulatory responses in producing the same protein. Therefore, it is important to understand how different TSSs of a gene is selected in different cells, tissues, and developmental stages and reveal key genes that regulate this selection. The proposed research project is relevant to the mission of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) because it will advance our understanding of the TSS selection mechanism with broad medical implication.

PI_NAMEs: CHEN, JIAYING  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: 3' Untranslated Regions;5' Untranslated Regions;Affect;ATAC-seq;Bioinformatics;Biological Process;Caenorhabditis elegans;Cell Maintenance;Cell Nucleus;cell type;Cells;ChIP-seq;Chromatin;chromatin protein;Code;Complex;Computer Analysis;Congenital Abnormality;Data;Databases;Defect;Development;Disease;DNA Polymerase II;DNA Transposable Elements;DNA-Directed RNA Polymerase;domain mapping;Drosophila genus;Embryo;Enhancers;Epigenetic Process;epigenetic regulation;experimental study;fly;Fractionation;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Genomic Segment;germline stem cells;Goals;gonad development;HDAC3 gene;Histones;Human;Immunofluorescence Microscopy;Immunoprecipitation;insight;knock-down;Knock-out;Knowledge;Literature;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Medical;Messenger RNA;Methods;Mission;Molecular;mutant;Mutate;National Institute of Child Health and Human Development;novel;Organism;Ovarian;Ovary;Pathway interactions;piRNA;Polymerase;protein function;Proteins;recruit;Regulation;Repression;Research Project Grants;response;RNA;Role;Schizophrenia;Site;Small Interfering RNA;Specific qualifier value;stem cell self renewal;System;Tissues;Transcript;Transcription Initiation;Transcription Initiation Site;Transcriptional Regulation;Untranslated RNA;Validation;Work

PROJECT_TITLE: Deciphering the Function of Piwi in Selecting Transcription Start Sites

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-U(20)L]


NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Infant Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE  Evidence-based guidelines inform the resuscitation of infants after birth, yet implementation of evidence- based practices and national guidelines is not uniform. Organizational culture (the beliefs, perceptions, and values in an organization) is an important and understudied factor in implementation of evidence-based practices for resuscitation. This proposal seeks to adapt and validate a resuscitation-specific measure of organizational culture, examine the association between organization culture and implementation of evidence- based practices, and thereby identify potential opportunities to improve neonatal resuscitation process and ultimately patient outcomes.

PI_NAMEs: FOGLIA, ELIZABETH ;HANDLEY, SARA CHRISTINE (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Academy;Address;Admission activity;Adoption;American;Attention;Baseline Surveys;Behavioral;Belief;Birth;Caring;Cessation of life;Characteristics;Clinical;Closure by clamp;Collaborations;Communication;Communication Barriers;Cross-Sectional Studies;Data;Delivery Rooms;Development;disability;Discipline;Dissemination and Implementation;Education;Educational Curriculum;Elements;Environment;Event;evidence base;evidence based guidelines;Evidence based practice;Factor Analysis;follow-up;Funding;Future;Goals;Guideline Adherence;Guidelines;health care settings;Hospitals;implementation context;implementation outcomes;improved;Infant;Infant Care;Infrastructure;instrument;Intervention;Measures;member;Modeling;National Institute of Child Health and Human Development;Neonatal Intensive Care Units;neonatal resuscitation;Newborn Infant;Organizational Culture;Outcome;patient population;Patient-Focused Outcomes;Patients;Pediatric Hospitals;Pediatrics;Penetration;Perception;Philadelphia;Physiologic Thermoregulation;pilot test;Premature Infant;prevent;Process;programs;Promoting Action on Research Implementation in Health Services framework;Property;Psyche structure;psychologic;Psychometrics;Quality of Care;Recommendation;Reporting;Research;respiratory;response;Resuscitation;Role;Safety;secondary analysis;secondary outcome;skills;sound;success;support network;surfactant;Surveys;Testing;Time;United States National Institutes of Health;Validation;Variant;ventilation;Work

PROJECT_TITLE: Understanding organizational culture and implementation of evidence-based resuscitation practices

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Gene Therapy;Genetics;Hematology;Immunotherapy;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: T-cells are a type of white blood cell that are needed to fight infections and can be artificially programmed to destroy cancer cells in patients. The goal of this project is to define whether increasing the activity of the gene BCL11B will expedite recovery of T-cells after bone marrow transplantation and improve the ability of programmed T-cells to kill cancer cells. The potential benefit of the knowledge gained from this project is the development of new methods to improve the recovery of the immune system after bone marrow transplantation, and ways to more effectively program T-cells to fight cancer.

PI_NAMEs: PAREKH, CHINTAN  (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Acceleration;Address;Allogenic;alpha-Thalassemia;anti-cancer;B-Cell Acute Lymphoblastic Leukemia;Binding;Bone Marrow Transplantation;cancer cell;CAR T cell therapy;CD19 gene;Cell Differentiation process;Cell Physiology;Cell Therapy;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;ChIP-seq;Chromatin;Complex;Consolidation Therapy;curative treatments;cytokine;cytotoxic;Data;Development;Disease remission;efficacy evaluation;engineered stem cells;Engineering;Epigenetic Process;exhaustion;fighting;Frequencies;gain of function;Gene Expression;Generations;Genes;Genetic Transcription;Goals;graft vs host disease;Hematopoiesis;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;hematopoietic transplantation;Human;human data;humanized mouse;Immune;Immune system;Immunity;Immunotherapy;Impairment;improved;improved outcome;In Vitro;in vivo;Infection;innovation;insight;Kinetics;knock-down;Knowledge;Lentivirus;leukemia;leukemia relapse;leukemia treatment;Leukocytes;Life;loss of function;Malignant Neoplasms;Mature T-Lymphocyte;Mediating;Memory;Methods;Modeling;Monitor;mouse model;Mus;Neuroblastoma;neutralizing antibody;NOTCH1 gene;NOTCH3 gene;novel;novel strategies;Nucleosomes;Outcome;overexpression;Patients;peripheral blood;Phenotype;preclinical efficacy;Process;Production;progenitor;programs;Proliferating;Recovery;recruit;Recurrence;Regulation;Relapse;Repression;response;Role;Safety;Secondary to;Signal Transduction;single-cell RNA sequencing;Solid;Solid Neoplasm;Specific qualifier value;stem cell migration;T cell differentiation;T cell reconstitution;T cell regulation;T-Cell Activation;T-Cell Development;T-Lymphocyte;Testing;Thymus Gland;Toxic effect;transcription factor;Transplantation;tumor microenvironment;Tumor Suppressor Proteins;Up-Regulation;Work

PROJECT_TITLE: BCL11B activation as an approach for enhancing the efficacy of immunotherapy

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Autoimmune Disease;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Lupus

PI_NAMEs: GORMAN, JACQUELYN  (contact)

PROJECT_TERMS: Affect;Alanine;Alleles;American;Amino Acids;Antinuclear Antibodies;Autoantigens;Autoimmune Diseases;Autoimmunity;C-terminal;CD4 Positive T Lymphocytes;Cell Separation;cell type;Cells;Codon Nucleotides;Coupled;Dendritic Cells;Disease;Double-Stranded RNA;effector T cell;Environmental Risk Factor;Etiology;Exhibits;Exposure to;Gene Expression;Genes;Genetic;Genetic Transcription;genetic variant;genome wide association study;Glycolysis;helicase;Immune;Immune signaling;Immune Tolerance;In Vitro;in vitro Assay;in vivo;Inflammation;Inflammatory;Inflammatory Response;Interferon Type I;Interferons;Internet;IRF3 gene;Knock-in Mouse;Link;Lupus;lupus-like;Lymphocyte;Metabolic;Metabolic Pathway;Metabolism;Mitochondria;Modeling;mouse model;Mus;NF-kappa B;Nutrient;Oklahoma;Oxidative Phosphorylation;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Phenotype;Predisposition;Production;programs;Proteins;Research;response;Risk;Risk Factors;Role;sensor;Signal Pathway;Signal Transduction;Signaling Protein;Single Nucleotide Polymorphism;Source;Systemic Lupus Erythematosus;T cell differentiation;T cell response;T-Cell Activation;T-Lymphocyte Subsets;Testing;Therapeutic;Threonine;Variant;Viral;Virus Diseases

PROJECT_TITLE: Viral sensor IFIH1 promotes SLE through an altered interferon program


NIH_SPENDING_CATS: Natural Products

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative  The central objectives of this application are: (a) to develop new, reliable, and efficient, methodologies that enable the construction of stereochemically rich scaffolds and (b) to achieve the concise chemical syntheses of naturally occurring small molecules that possess intricate chemical structures. The results of these efforts should lead to the development of new strategies and tools for the preparation of various molecules of importance, including medicines.

PI_NAMEs: GARG, NEIL K (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Exploiting Unconventional Building Blocks in Chemical Synthesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


NIH_SPENDING_CATS: Brain Disorders;Estrogen;Mental Health;Neurosciences;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Several neurological and mental health disorders have notable sex differences in their prevalence or severity, which can be further amplified when co-morbidity is considered. Here we study the lateral habenula - rostromedial tegmental nucleus - midbrain dopamine pathway, which is implicated in many of these disorders, and the effect of circulating sex hormones on its function. This research will help us to understand whether this brain circuit underlies sex differences in several recalcitrant mental health disorders and may lead to new forms of treatment.

PI_NAMEs: BROWN, PAUL LEON (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Acute;addiction;Behavior;Brain;Castration;Cell Nucleus;Cells;Chronic;chronic pain;cohort;common symptom;comorbidity;Cues;Data;design;Development;Disease;Dopamine;dopaminergic neuron;Electrophysiology (science);Estradiol;Estrogen Receptors;Estrogen Replacements;Estrogens;Exhibits;experimental study;Exposure to;Female;Fire - disasters;Fostering;Gonadal Hormones;Gonadal Steroid Hormones;Habenula;hormone regulation;Hormones;in vivo;Knowledge;Laboratories;Lateral;Learning;Literature;male;Mediating;men;Mental Depression;Mental disorders;Midbrain structure;motivated behavior;Motivation;Nature;Neurologic;Neurons;neurophysiology;novel;Ovariectomy;Parkinson Disease;patch clamp;Pathway interactions;Pattern;Permeability;Play;Predisposition;Prevalence;Property;Rattus;Research;response;Rewards;Rodent;Role;Schizophrenia;Severities;sex;Sex Differences;Steroids;Substance abuse problem;symptomatology;Symptoms;Testing;Testosterone;therapy development;With laterality;Woman;Work

PROJECT_TITLE: Estrogen modulation of the lateral habenula and its ability to inhibit midbrain dopamine neurons

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: DREXEL UNIVERSITY

PHR: Although screening is a known strategy to facilitate early detection of autism spectrum disorders (ASD), screening during routine toddler pediatric check-ups is not universal. The current study will examine the feasibility of ASD screening in childcare centers, by exploring barriers and facilitators of systematic screening by childcare providers, and examining the performance of a widely used screening tool in this novel setting. Screening in childcare centers represents an important complementary strategy to increase access to early ASD screening, particularly for underserved children.

PI_NAMEs: ROBINS, DIANA L (contact);WIECKOWSKI, ANDREA TRUBANOVA

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: access disparities;Address;Age;Age disparity;Agreement;autism spectrum disorder;autism symptoms;Black race;care providers;checkup examination;Child;Child Behavior;Child Care;Child Development;Child Support;Childhood;Communities;community setting;Data;Decision Making;design;Development;Diagnosis;Disabled Children;Disadvantaged;disorder risk;Disparity in diagnosis;disparity reduction;early childhood;Early Diagnosis;Early identification;Early Intervention;early screening;Early treatment;Education;Enrollment;ethnic disparity;Evaluation;experience;Exposure to;Family;follow-up;Goals;health care availability;HIV;Home;Hour;implementation facilitators;Improve Access;improved;improved outcome;Income;informant;innovation;insight;Intervention;Interview;Link;Lived experience;lower income families;Measures;Medical;Mental Health;Methods;minority children;Modified Checklist for Autism in Toddlers;novel;novel strategies;Outcome;Parents;pediatrician;peer;Perception;Performance;Pilot Projects;Play;Poverty;Primary Care;Process;Prognosis;Provider;Qualitative Methods;Questionnaires;racial disparity;Recommendation;Reporting;Research;research clinical testing;Resources;Risk;satisfaction;screening;Screening procedure;Screening Result;social stigma;socioeconomic disparity;Sociology;Structure;Testing;theories;Thick;Time;Toddler;Trust;underserved community;uptake;Well Child Visits

PROJECT_TITLE: Autism Screening in Childcare Settings


PHR: Project Narrative Obesity is an independent risk factor for the development of chronic kidney disease, but current strategies for the prevention and treatment of obesity related kidney injury are incompletely effective. Lipotoxicity is a recently identified process that contributes to kidney injury in the setting of obesity, but the mechanisms underlying lipotoxicity in the kidney are not fully understood. This studies in this proposal will investigate the role of ATP6AP2 in promoting renal lipotoxicity with the goal of providing a basis for novel therapeutic strategies in the management of obesity related kidney disease.

PI_NAMEs: CULVER, SILAS A (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: absorption;Albumins;Animals;Area;Award;Basic Science;Binding;Biomedical Research;career;career development;Cell Death;cell type;Cells;Chronic Kidney Failure;Complement;Complex;Coupled;Data;Development;Development Plans;Diabetes Mellitus;diabetic;diet-induced obesity;Endocrinology;Endocytosis;endoplasmic reticulum stress;Environment;Epithelial Cells;Excretory function;experience;fatty acid oxidation;Fatty Acids;Filtration;Foundations;FRAP1 gene;Functional disorder;Future;Genus Hippocampus;Goals;High Fat Diet;High Pressure Liquid Chromatography;In Vitro;in vitro Model;in vivo;Injury to Kidney;interest;Intracellular Accumulation of Lipids;intravital imaging;intrinsic factor-cobalamin receptor;Investigation;Kidney;kidney cell;kidney cortex;Kidney Diseases;kidney dysfunction;knock-down;Knock-out;Knockout Mice;Laboratories;LDL-Receptor Related Protein 2;lipid metabolism;lipidomics;Lipids;Magnetic Resonance Imaging;Mass Spectrum Analysis;Mediating;Mentors;Mentorship;Methods;microscopic imaging;Microscopy;mitochondrial dysfunction;Modification;mouse model;Mus;Nephrons;new therapeutic target;novel strategies;novel therapeutic intervention;Obesity;Obesity associated kidney disease;Obesity Epidemic;obesity management;obesity treatment;oxidation;Oxidative Stress;Pathology;Peripheral;pharmacologic;Physicians;Predisposition;Prevalence;prevent;Prevention;Prevention strategy;Process;Proton-Translocating ATPases;Proximal Kidney Tubules;receptor mediated endocytosis;Research;research facility;Research Training;Risk Factors;Role;Scanning;Science;Scientist;Signal Transduction;Small Interfering RNA;Techniques;Testing;Time;Tissues;Training;Transgenic Mice;Translational Research;Universities;uptake;urinary;vacuolar H+-ATPase;Virginia;Writing

PROJECT_TITLE: Role of Atp6ap2 in renal proximal tubule lipotoxicity

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention

ORG_CITY: HANOVER

ORG_DEPT: PSYCHOLOGY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE Attention deficit hyperactivity disorder, schizophrenia, suicidal depression, and behavioral addictions all include components of dysregulated reward processing and impulsivity. The etiology of these disordered phenotypes can occur during adolescence when the underlying neural circuits are undergoing maturation. The proposed research will determine the timecourse and neural-circuit mechanisms of a pathological developmental trajectory and identify novel intervention and treatment targets.

PI_NAMEs: NAUTIYAL, KATHERINE M (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: addiction;Address;Adolescence;Adolescent;Adolescent Development;Adult;Aggressive behavior;Anxiety;Attention deficit hyperactivity disorder;Automobile Driving;Award;Basic Science;Behavior;behavior test;Behavioral;Behavioral Mechanisms;behavioral phenotyping;biobehavior;Biological;Borderline Personality Disorder;Brain;Calcium;career;cell type;Cells;cognitive development;Complex;Corpus striatum structure;Data;Development;Disease;Etiology;Event;experimental study;Funding;genetic manipulation;Goals;high reward;high risk;Home;Impulsive Behavior;Impulsivity;in vivo calcium imaging;Individual;innovation;Intervention;Knock-out;Knowledge;Learning;Long-Term Depression;longitudinal human study;Measures;Mediating;Mental Depression;Mental disorders;Methods;microendoscope;Molecular;Mouse Cell Line;Mus;National Institute of Mental Health;Nature;neural;neural circuit;neurodevelopment;neuromechanism;Neuromodulator;Neurons;novel;Obsessive-Compulsive Disorder;Operant Conditioning;Outcome;Pathologic;Pathology;Pharmacotherapy;Phenotype;prevent;Prevention;Process;programs;Research;Research Personnel;Research Project Grants;response;reward processing;Rewards;Rodent;Role;Schizophrenia;Scientist;Serotonin;Serotonin Receptor 5-HT1B;Shapes;Signal Transduction;Stimulus;Strategic Planning;suicidal;Synapses;System;Techniques;Technology;Testing;Time;Transgenic Mice;Work

PROJECT_TITLE: Serotonin modulation of the development of neural circuits underlying reward processing and impulsivity in adolescents


NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases;Microbiome

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: The primary focus of this research proposal is for the discovery and elucidation of novel biochemical pathways for the biosynthesis and metabolism of simple and complex carbohydrates in the human gut microbiome. The metabolic diversity within these bacteria contributes significantly to the maintenance of human health and physiology. The determination of the substrate and reaction diversity contained within these newly discovered metabolic reactions will provide unique insights into the molecular mechanisms for the evolution and development of novel enzymatic activities and will provide potential targets for therapeutic intervention.

PI_NAMEs: RAUSHEL, FRANK M. (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TITLE: The Discovery of Novel Metabolic Pathways for the Biosynthesis and Degradation of Complex Carbohydrates within the Human Gut Microbiome


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Clinical Research;Genetics;Infectious Diseases

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Pseudomonas aeruginosa poses a major threat to human health due to limited treatment options and its ability to become resistant to antibiotics. The discovery of new drugs targeting P. aeruginosa and other Gram- negative bacteria is especially challenging due to the exclusion of most small molecules by an impermeable cell wall, coated by an electronegative matrix of lipopolysaccharide (LPS). This proposal aims to develop anti- pseudomonal LPS transport inhibitors that may improve human health, but can simultaneously be leveraged to elucidate the regulatory pathways underpinning LPS transport in P. aeruginosa.

PI_NAMEs: ROMANO, KEITH PATRICK (contact)

PROJECT_TERMS: Advisory Committees;Affect;Antibiotic Resistance;Antibiotic susceptibility;Antibiotics;Arabinose;Area;Award;Bacterial Antibiotic Resistance;bacterial genetics;Binding;Biochemical;Biochemistry;Bioinformatics;Biological;Biology;Biosynthetic Proteins;Carbapenems;career;Carrier Proteins;cell growth;Cell Membrane Permeability;Cell Wall;Cells;cellular targeting;Chemical Structure;Chemicals;Chronic lung disease;Collaborations;Complement;Cryoelectron Microscopy;Cytoplasm;Data;Data Set;drug candidate;drug development;drug discovery;efflux pump;Electrostatics;Engineering;Environment;Enzymes;Exclusion;Foundations;Funding;Future;Gene Expression Profiling;Genes;Genetic;Genetic Screening;Genetic Transcription;genome-wide;Genomics;Goals;Gram-Negative Bacteria;Hand;Health;Human;human pathogen;Immune system;improved;inhibitor;insight;K-Series Research Career Programs;knowledge base;Lead;lead candidate;lead optimization;Lipopolysaccharide Biosynthesis Pathway;Lipopolysaccharides;Medicine;Membrane;Mentors;Mentorship;Metabolic Pathway;Methods;Molecular Probes;Mutagens;mutant;new therapeutic target;Nosocomial Infections;novel;novel strategies;novel therapeutics;pathogenic bacteria;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Physicians;promoter;protein expression;Proteins;Pseudomonas aeruginosa;Pulmonology;Regulator Genes;Regulatory Pathway;Reporter;Research Personnel;Research Proposals;Resistance;response;Science;Scientist;screening;small molecule;statistics;structural biology;Structure;Structure-Activity Relationship;Techniques;Testing;Therapeutic Agents;Training;Training Programs;Training Support;transcriptomics;Translating;transport inhibitor;Work

PROJECT_TITLE: Targeting lipopolysaccharide transport machinery in Pseudomonas aeruginosa

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung

ORG_CITY: ATHENS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Project Narrative Myristoylation facilitates proteins’ association with the cell membrane, and their encapsulation into extracellular vesicles. This project will produce extracellular vesicles encapsulating Cas13d/crRNA ribonucleoprotein by Cas13d myristoylation and incorporating the spike protein into the EVs membrane to confer transfection specificity to target SARS-CoV-2 infected respiratory epithelial cells. The generated extracellular vesicles will provide an avenue for the treatment of COVID-19.

PI_NAMEs: CAI, HOUJIAN  (contact)

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 2019-nCoV;ACE2;airway epithelium;Anti-viral Agents;BCAR1 gene;Binding;Biological;Biology;Carbon;Cause of Death;Cell Communication;Cell membrane;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Coated vesicle;Complex;Conditioned Culture Media;COVID-19;COVID-19 patient;COVID-19 treatment;CRISPR/Cas technology;Data;Encapsulated;Engineering;Epithelial Cells;Event;extracellular vesicles;Future;Gene Expression;Gene Modified;Generations;Genes;Genetic;Genetic Diseases;Genetic Engineering;genome editing;genomic RNA;Glycine;improved;In Vitro;in vivo;influenza infection;Knock-out;Knowledge;Lipids;Lung;Mediating;Membrane;Mesocricetus auratus;Messenger RNA;Methods;MicroRNAs;Modeling;Modification;Molecular;mortality;myristoylation;N-terminal;nanoparticle;Nucleocapsid;pandemic disease;Persons;Play;posttranscriptional;Production;Proliferating;Proteins;receptor;Ribonucleoproteins;RNA;RNA Sequences;Role;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;SARS-CoV-2 spike protein;Saturated Fatty Acids;Severity of illness;Specificity;src-Family Kinases;Structure of parenchyma of lung;System;Technology;Testing;therapeutic genome editing;Tissues;Transfection;transmission process;treatment strategy;Vaccines;Variant;Viral;viral genomics;Viral Load result;Viral Proteins;Virus Assembly

PROJECT_TITLE: Extracellular vesicles encapsulating CRISPR machinery for treatment of SARS-CoV-2 infection

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]