NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The overarching goal of this three-year, late-stage U01 proposal is to develop a brain penetrant microtubule-stabilizing triazolopyrimidine (TPD) as a drug candidate for Alzheimer’s disease and related neurodegenerative diseases. As part of this proposal, a selected TPD candidate will be advanced through investigational new drug (IND)-enabling studies with the goal of submitting an IND application to the FDA.

PI_NAMEs: BRUNDEN, KURT R.;CAFFREY, CONOR  (contact)

PROGRAM_OFFICER_NAME: REFOLO, LORENZO

PROJECT_TERMS: Acute;Adverse event;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;aqueous;Axon;Axonal Transport;Binding;Binding Proteins;Biological Availability;Biological Markers;Brain;Caco-2 Cells;cancer clinical trial;Canis familiaris;Clinical;cognitive performance;corticobasal syndrome;Cyclic GMP;density;Development;Disease;Disease Progression;Dose;drug candidate;Drug Compounding;drug development;Drug Kinetics;efficacy testing;Enzymes;epothilone D;Exhibits;Formulation;Frontotemporal Lobar Degenerations;Future;Gene Mutation;Goals;hyperphosphorylated tau;Impairment;improved;In Vitro;Inherited;Investigational Drugs;Investigational New Drug Application;Laboratories;Lesion;MAPT gene;Metabolic;Micronucleus Tests;Microtubule stabilizing agent;Microtubule-Associated Proteins;Microtubules;Modeling;Modification;Molecular Motors;mouse model;Mus;Natural Products;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;neuron loss;Neurons;Neuropil Threads;novel;Oral;Pathologic;Pathology;Patients;Permeability;Pharmaceutical Preparations;Phase Ib Clinical Trial;Phase Ib Trial;Pick Disease of the Brain;Plasma;Play;pre-clinical;Process;Progressive Supranuclear Palsy;prototype;Qualifying;Rattus;Role;Safety;Science;Solubility;Structure;Structure-Activity Relationship;tau function;tau Proteins;tau-1;Tauopathies;Testing;Toxic effect;Toxicology;Transgenic Mice;Transgenic Organisms;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Development of a MT-stabilizing agent for the treatment of tauopathies

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-J (M3)]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Kidney Disease;Orphan Drug;Rare Diseases

ORG_CITY: SALT LAKE CITY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ORTHOPEDICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Alveolar soft part sarcoma is a deadly cancer that is caused by a mutation resulting in the aberrant fusion of two genes, ASPSCR1 and TFE3. Alterations in gene expression caused by the fusion protein depend on interactions with a protein unfolding machine known as VCP. This study aims to define the role of VCP in driving the altered gene expression associated with the ASPSCR1-TFE3 fusion protein.

PI_NAMEs: JONES, KEVIN BRUCE (contact);SHEN, PETER

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: 3-Dimensional;Address;Alveolar Soft Part Sarcoma;Architecture;ATP phosphohydrolase;Automobile Driving;Binding;Biochemical;Biochemistry;Biological Assay;Biology;cancer cell;Cell Line;Cell Nucleus;Cells;Childhood Renal Cell Carcinoma;Chimeric Proteins;ChIP-seq;Chromatin;Chromosomal translocation;cofactor;Complex;Cryoelectron Microscopy;Cytoplasm;Cytoplasmic Protein;Data;Dissociation;DNA Binding;Enhancers;Evaluation;experimental study;Fusion Oncogene Proteins;Gene Expression;gene repression;Genes;Genetic Transcription;Genome;Histological Techniques;Human;Human Cell Line;Immunoprecipitation;In Vitro;inhibitor;insight;kidney cell;Knowledge;Malignant Neoplasms;Mediating;member;Membrane Proteins;Metabolic stress;Modeling;mouse model;Mus;mutant;Mutation;Nature;Negative Staining;Neuromuscular Diseases;new therapeutic target;Nuclear;NuRD complex;Oncogenic;Other Genetics;Outcome;Patients;Positioning Attribute;Prognosis;promoter;protein folding;Proteins;proteostasis;Quality Control;Recommendation;Renal Cell Carcinoma;Repression;Rest;Role;Sarcoma;scaffold;segregation;Site;small molecule inhibitor;stoichiometry;Structure;Testing;TFE3 gene;transcription factor;Transcriptional Regulation;transcriptional reprogramming;Transmission Electron Microscopy;tumor;Tumor Tissue;unfoldase

PROJECT_TITLE: VCP in ASPSCR1::TFE3-driven oncogenic transcription reprogramming

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BIRMINGHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Addressing disparities in health and healthcare for minoritized older adults requires innovation in aging research at the nexus of geriatric medicine, gerontology, and palliative care research. Community Based Participatory Research (CBPR) is an important and promising strategy to meet this challenge because it has been shown to reduce health disparities, decrease distrust in healthcare system, and result in positive health outcomes. To accomplish the goal of leveraging the candidate’s leadership in health equity and CBPR to create a training program in CBPR that will result in a path towards health equity for older adults, the candidate will (1) Build a national CBPR training program focusing on health equity in older populations; (2) Measure program outcomes, and (3) Develop a program sustainability plan.

PI_NAMEs: ELK, RONIT  (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Academia;Address;Administrator;Adult;Affect;Aging;American;Area;Award;career;Caregivers;Caring;Clinical;Communities;community academic partnership;community based participatory research;culturally appropriate intervention;curriculum development;design;Development;Disparity;distrust;effectiveness evaluation;empowerment;end of life;Equity;evidence base;Fostering;Funding;Future;Geriatrics;Gerontology;Goals;Health;health care availability;health care disparity;health disparity;health equity;health goals;Health Occupations;Health Professional;Health system;Healthcare;Healthcare Systems;human old age (65+);implementation science;implicit bias;improved;Incubators;innovation;Institution;Institutional Racism;Knowledge;Leadership;Measures;member;Mentors;Mentorship;method development;Methods;Minority;minority communities;Minority Groups;Minority Health Research;minority healthcare;Morbidity - disease rate;mortality;older adult;Older Population;Outcome;outreach program;Palliative Care;Patients;Persons;Professional Organizations;Program Development;Program Sustainability;programs;public health relevance;Reduce health disparities;Research;Research Personnel;Research Project Grants;research study;Research Training;Resources;Scholarship;Schools;skill acquisition;skills;Stream;success;Training;Training Programs;Trust;Underrepresented Populations;Vision

PROJECT_TITLE: Advancing CBPR to Spearhead Health Equity for Minority Older Adults.

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


ADMINISTERING_IC: NS

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Complementary and Integrative Health;Machine Learning and Artificial Intelligence;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative The brain receives signals from all of our internal organs through the sensory vagus nerve, but the way in which this information modulates individual neurons and circuits is not understood. This proposal investigates how internal organ information is represented in the sensory vagus nerve. Our work will then enable investigating how each internal organ signal influences brain function and behavior.

PI_NAMEs: HERNANDEZ NUNEZ, LUIS ALONSO (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Action Potentials;Afferent Neurons;Anatomy;Animals;Anterior;awake;Behavior;Behavioral;Biological Assay;Brain;Brain region;Calcium;Cardiovascular system;Cells;Collaborations;Communication;Cues;Data;Data Set;Decision Making;Development;Dimensions;Disadvantaged;Emotions;environmental change;experience;Eye;Fire - disasters;Fishes;Functional Imaging;Ganglia;Genetic;genetic manipulation;Gills;Glutamates;Grant;Head;Heart;heart imaging;Heart Rate;Image;Immobilization;Individual;instrument;Investigation;Label;Larva;Left;Light;Machine Learning;machine vision;Mammals;Maps;Measurement;Measures;Microscope;mind body interaction;Modeling;Monitor;Motility;Motor;mouse model;Movement;neural;neural circuit;Neurons;Neurosciences;novel;Optics;Organ;Organism;Oxygen;Phase;Positioning Attribute;Pressoreceptors;Procedures;Process;Property;Publishing;Reporting;Research;Resolution;respiratory;Respiratory physiology;response;Rest;Rodent;Role;Sensory;Sensory Ganglia;Sepharose;Signal Transduction;Speed;Stimulus;System;Tail;Techniques;Technology;Temperature;Transgenic Organisms;transmission process;two photon microscopy;Vagus nerve structure;ventilation;Viscera;Visceral;Visual;voltage;Work;Zebrafish

PROJECT_TITLE: Viscerosensory Modulation of Brain Circuits in Larval Zebrafish

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-D (55)]


NIH_SPENDING_CATS: Cancer;Clinical Research;Dissemination and Implementation Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative We will design implementation strategies for systematic, comprehensive, and validated hereditary cancer risk assessment. Our goal will be to design strategies that are sustainable, scalable, and equitable in diverse settings and many patient populations. We will test these strategies in 3 diverse community health systems.

PI_NAMEs: SYNGAL, SAPNA  (contact)

PROGRAM_OFFICER_NAME: BURNETT, ANDREA NICOLE

PROJECT_TERMS: Address;Adoption;Algorithms;Appointment;Award;cancer care;cancer risk;Cancer-Predisposing Gene;Caring;Certification;Clinic;Clinical;clinical decision support;Clinical Oncology;clinically actionable;clinically significant;cohort;Communication Barriers;Communities;Community Health;Community Health Systems;Data;design;Development;disadvantaged background;disease-causing mutation;Dissemination and Implementation;Early identification;Effectiveness;eHealth;Ensure;Equity;Evaluation;Family;Family Cancer History;Fast Healthcare Interoperability Resources;Funding;General Population;Genes;Genetic;genetic counselor;genetic panel test;genetic testing;Geography;Germ Lines;Goals;Guidelines;Health;health application;health care settings;health inequalities;Health Resources;Health system;Healthcare;Healthcare Systems;Hereditary Malignant Neoplasm;Hereditary Neoplastic Syndromes;Hereditary Nonpolyposis Colorectal Neoplasms;implementation design;implementation research;implementation science;implementation strategy;implementation study;improved;Individual;Inherited;Journals;Knowledge;literacy;Malignant Neoplasms;marginalization;marginalized population;Medical;medical specialties;medically underserved population;Methodology;Methods;Modeling;Oncogenes;Outcome;Outcome Study;patient population;patient-clinician communication;Patients;Phase;Population;Predictive Value;Preventive;Primary Care;primary care provider;programs;Provider;Publishing;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Recording of previous events;Reporting;Resources;response;Risk;Risk Assessment;risk prediction;risk variant;Screening for cancer;Site;standard of care;Syndrome;targeted cancer therapy;Testing;Time;tool;Work

PROJECT_TITLE: Inclusion of Diverse and Medically Underserved Populations in the Design and Implementation of the PREMMplus Patient-Facing App

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: Project Narrative: Influenza, especially aggressive types like H1N1, can severely damage lungs, leading to dysplastic repair and the formation of Krt5+ basal cell pods in the damaged alveolar. Our research is centered on a protein, "Ezh2", which appears to diverge from its conventional role within the Polycomb Repressive Complex 2 (PRC2) to uniquely regulate basal cell behavior following influenza infection. The goals of this proposal are to study the unique role of Ezh2 in regulating basal cell dynamic post severe influenza infection and aim to offer insights into improving lung repair following influenza infections and potentially other lung diseases.

PI_NAMEs: YAO, CHANGFU  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Acute;acute infection;airway epithelium;Alveolar;Alveolus;Area;Automobile Driving;Basal Cell;Basal Cell Hyperplasia;Catalytic Domain;cell behavior;Cell Proliferation;cell type;Cells;Cessation of life;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Complex;cytokine;Data;Enhancers;epithelial stem cell;Exposure to;Gene Expression;gene repression;Gene Silencing;Gene Targeting;global health;Goals;Histones;Human;Hyperplasia;idiopathic pulmonary fibrosis;improved;In Vitro;in vivo;Infection;Influenza;Influenza A virus;Influenza A Virus, H1N1 Subtype;influenza infection;influenza virus strain;Injury;injury and repair;insight;interleukin-22;loss of function;Lung;Lung Diseases;lung injury;lung repair;Lysine;Mediating;Methylation;migration;Molecular;mouse model;Mus;Pathogenesis;Pattern;Peptide Initiation Factors;Phenotype;Phosphorylation;Play;Pod cells;Polycomb;Process;Proliferating;Proteins;pulmonary function;Pulmonology;Regulation;repaired;Replication-Associated Process;Research;Respiratory Failure;response;restoration;Role;Serine;Signal Transduction;Specific qualifier value;Structure of parenchyma of lung;Testing;tissue repair;Tissues;Transcription Coactivator;Up-Regulation;Viral Respiratory Tract Infection;Virulent

PROJECT_TITLE: PRC2 independent role of Ezh2 in regulation of basal cell dynamics post-influenza virus infection

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE Understanding the role that implicit bias plays in clinical dentistry—both in clinician decision-making and in the recruitment/ retention of the oral health workforce—is essential to advancing health equity and closing the gap in health disparities. The current project focuses on clinician decision-making by establishing a baseline prevalence of implicit bias among dentists in the United States and supporting dentists with implicit bias training. To advance diversity in the workforce, this project will provide psychosocial support to help students actively pursuing careers in the biomedical research enterprise mitigate the effects of implicit bias and other barriers to successful entry into the oral health workforce.

PI_NAMEs: BURNS, LOREL E;FLEMING, ELEANOR  (contact)

PROGRAM_OFFICER_NAME: IIDA, HIROKO

PROJECT_TERMS: Address;African American student;Area;Attitude;Behavior;Biomedical Research;black patient;Black Populations;Black race;career;Caring;Clinical;clinical decision-making;cohort;Computer Assisted;Data;Decision Making;Dental;Dental Care;Dental Education;Dental Schools;Dental Students;Dentistry;Dentists;direct patient care;Disease;edentulism;Education;Educational Curriculum;efficacy evaluation;empowerment;Equity;equity, diversity, and inclusion;ethnic disparity;Ethnic Origin;Evaluation;evidence base;Evidence based intervention;Focus Groups;Funding;health disparity;health equity;health inequalities;Health Personnel;Health Sciences;Healthcare;Healthcare Systems;Hispanic;implicit bias;interest;Intervention;Intervention Studies;Investigation;Licensure;Medicaid;Medical;Medical Research;Mentorship;Methods;National Institute of Dental and Craniofacial Research;Nurses;Observational Study;Oral health;Outcome;Pathway interactions;patient-clinician communication;Patients;Physicians;Play;Population;Prevalence;Procedures;programs;psychosocial;Psychosocial Assessment and Care;Public Health;Quality of Care;racial bias;racial disparity;racial health disparity;Randomized;recruit;Reproducibility;Research;Research Design;Role;Sampling;Scientist;Sequence Analysis;Strategic Planning;student participation;Students;System;Testing;theories;Time;tool;Tooth Extraction;Tooth structure;Training;Training and Education;Training Programs;Treatment Efficacy;treatment planning;Treatment/Psychosocial Effects;Trust;Unconscious State;undergraduate student;Underrepresented Populations;Underrepresented Students;United States;United States National Institutes of Health;Validity and Reliability;Visit

PROJECT_TITLE: Disrupting Implicit Bias in Dental Clinical Decision-Making and Mitigating Its Effect on the Dentist-Scientist Workforce Pathway

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-G (55)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ANN ARBOR

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE This proposal is relevant to public health because it will identify key pathologic pathways and identify novel therapeutic targets in choroideremia, which causes blindness early in life and has no treatment. It will also allow new horizons of research in RPE cell dysfunction and protease secretion in other chorioretinal degenerative diseases. This research addresses the mission of the National Eye Institute by significantly advancing therapeutic efforts to save vision.

PI_NAMEs: FAHIM, ABIGAIL  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Address;age related;Age related macular degeneration;Amino Acid Transporter;Amino Acids;Angiography;Area;Atrophic;Autophagocytosis;Blindness;Blood flow;Blood Vessels;Cell Culture Techniques;Cell Death;Cell Survival;Cells;Cessation of life;Child;Choroid;choroidal circulation;Choroideremia;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Data;Defect;Degenerative Disorder;density;Disease;Endothelial Cells;Extracellular Matrix;Extracellular Matrix Degradation;FRAP1 gene;Functional disorder;Future;Gelatinase A;gene replacement;Genes;Goals;Guanosine Triphosphate Phosphohydrolases;Histology;human induced pluripotent stem cells;in vivo;induced pluripotent stem cell;Inherited;innovation;Intervention;knock-down;Knock-out;Knockout Mice;Lead;Life;Lysosomes;Measures;Mediating;Membrane;Membrane Lipids;Mission;MMP2 gene;Modeling;Molecular;mouse model;Mus;Mutation;National Eye Institute;new therapeutic target;novel;novel therapeutics;Outcomes Research;Pathologic;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Peptide Hydrolases;Peripheral;pharmacologic;Photoreceptors;prenylation;protein transport;Proteins;Public Health;rab GTP-Binding Proteins;Research;Retina;Retinal Diseases;Retinal Dystrophy;Role;Signal Transduction;small hairpin RNA;Structure of retinal pigment epithelium;targeted treatment;Testing;Therapeutic;therapeutic target;therapy development;Thinness;Tissues;trafficking;translational study;Vision;young adult

PROJECT_TITLE: Retinal Pigment Epithelium Secreted Matrix Metalloproteinase 2 as a Novel Target in Choroideremia

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Obesity;Eating Disorders;Mental Health;Neurosciences;Nutrition;Obesity;Pediatric;Physical Activity;Prevention

ORG_CITY: ATHENS

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Project Narrative Consumption of a Western Diet, high in saturated fat and sugar, during the adolescent phase of development impairs hippocampal-dependent learning and memory function during adulthood. The hippocampus is also known to regulate aspects of food intake control that are relevant for obesity, including impulsive behaviors to obtain and consume palatable yet otherwise unhealthy food. We propose to determine the impact of an adolescent Western Diet on food impulsive behavior, identify the neurobiological circuits involved, and determine whether the impact of the diet can be reversed by exercise and/or treatment with a GLP1R agonist.

PI_NAMEs: NOBLE, EMILY ELIZABETH (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Adolescence;Adolescent;Adult;Adult women;Aerobic Exercise;Agonist;analog;Animal Feed;Animals;Attenuated;Behavior;Behavior Therapy;Behavioral;Binge Eating;Binge eating disorder;Body Weight decreased;Brain region;Calcium;Child;Choice Behavior;clinically relevant;Consumption;critical period;Data;Development;Diet;diet-induced obesity;dietary;discounting;Eating;Eating Behavior;Environmental Risk Factor;Exercise;experimental study;FDA approved;Female;Food;Functional disorder;Genetic;GLP-I receptor;glucagon-like peptide 1;good diet;Growth;Health Food;Heritability;Hippocampus;Human;imaging approach;Impairment;improved;Impulsive Behavior;Impulsivity;in vivo;in vivo calcium imaging;in vivo imaging;Inbred SHR Rats;incretin hormone;Learning;Life;Link;Longitudinal Studies;male;Measures;Medial;Mediating;Memory;Memory impairment;Modeling;neural circuit;Neuroanatomy;Neurobiology;neurodevelopment;Neuronal Plasticity;Neurons;Neurosciences Research;Nucleus Accumbens;Obesity;Outcome;Pathway interactions;pharmacologic;Phase;Predisposition;Prefrontal Cortex;Publishing;Rattus;reinforcer;response;Rewards;Rodent;Role;saturated fat;Sex Differences;Signal Transduction;sugar;Testing;Time;trait impulsivity;Twin Studies;Weight maintenance regimen;western diet;Work

PROJECT_TITLE: Diet and the neurodevelopment of impulsivity

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Aging;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE Blood-forming stem cells in the bone marrow regenerate blood and immune cells throughout life. Defects in stem cell maintenance that occur during aging lead to anemia, impaired immunity, bone marrow failure, and leukemia, but the underlying cause of these defects is largely unknown. This proposal will examine if blood-forming stem cell maintenance and longevity is regulated by errors in protein synthesis, and if increasing the fidelity of protein synthesis delays onset of age-related stem cell defects and extends lifespan.

PI_NAMEs: BENNETT, ERIC J;SIGNER, ROBERT A.J. (contact)

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: Age of Onset;age related;age related changes;age related decline;Aging;Anemia;Biogenesis;biological adaptation to stress;Biological Assay;Blood;Blood Cells;Bone Marrow;Bone marrow failure;Cell Maintenance;cell type;Cells;Cellular Assay;Cellular Stress;Data;Defect;Environment;exhaustion;Exhibits;experimental study;extend lifespan;fitness;fly;Functional disorder;Genetic;Genetic Transcription;Goals;hallmarks of aging;healthspan;heat-shock factor 1;Hematopoiesis;Hematopoietic;hematopoietic stem cell aging;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Human;Immune;Immune System Diseases;Immunity;Impairment;improved;in vivo;Incidence;Intervention;Lead;leukemia;Life;life span;Longevity;Malignant Neoplasms;Mammals;misfolded protein;mouse model;Mus;Myelogenous;Natural regeneration;old mice;older adult;Pathway interactions;preservation;prevent;Production;progenitor;Protein Biosynthesis;protein purification;Proteins;Proteome;Proteomics;proteostasis;proteostasis loss;proteotoxicity;Regenerative capacity;Reporter;Reporter Genes;Reporting;Research;Resolution;Ribosomes;self-renewal;sensor;stem cell exhaustion;stem cell function;stem cells;Stress;Testing;Therapeutic;transcriptome sequencing;Transgenic Organisms;translational impact;Translations;Transplantation;Work;young adult

PROJECT_TITLE: Translation Fidelity in Hematopoietic Stem Cell Aging and Longevity

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: NARRATIVE  Antigen presentation is a critical component of anti-tumor immunity. While numerous classes of tumor specific antigens have been described, a deep understanding of the most clinically valuable immune targets and the mechanisms by which they are presented remains limited. In this proposal, we will utilize a multidisciplinary approach to understand non-canonical antigens in lung cancer that will pave the way forward to broaden the antigen repertoire that can be targeted for next-generation precision immunotherapies.

PI_NAMEs: JAEGER, ALEX  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Ablation;Address;Anabolism;anti-tumor immune response;Antigen Presentation;Antigen Presentation Pathway;Antigens;Binding;cancer cell;Cancer cell line;Cancer Vaccines;CD8-Positive T-Lymphocytes;Cells;chemotherapy;Clinical;clinical development;Complex;Coupled;CRISPR/Cas technology;Custom;cytotoxic;Data;defined contribution;design;Engineering;Event;Exhibits;experimental study;Genetically Engineered Mouse;Goals;Heterogeneity;homoharringtonine;Human;human cancer mouse model;Immune;Immune Targeting;immunogenicity;Immunologic Surveillance;Immunotherapy;immunotherapy trials;In Vitro;in vivo;individual patient;Infiltration;inhibitor;insertion/deletion mutation;interdisciplinary approach;interest;Link;lung cancer cell;Major Histocompatibility Complex;Malignant neoplasm of lung;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Measures;Mediating;mouse model;Mus;Mutate;Mutation;neoantigens;next generation;Non-Small-Cell Lung Carcinoma;novel;Open Reading Frames;Organoids;Pathway interactions;Patients;Peptide Synthesis;Peptides;personalized immunotherapy;pharmacologic;Physiological;polypeptide;Positioning Attribute;pre-clinical;Process;Proteins;proteogenomics;Quality Control;Resolution;response;ribosome profiling;Ribosomes;Role;Shapes;Somatic Mutation;Source;success;T cell response;tool;Translations;transplant model;tumor;Tumor Antigens;tumor growth;Tumor Immunity;ubiquitin-protein ligase;Ubiquitination;Vaccines

PROJECT_TITLE: Interrogating the relationship between translational dynamics and non-canonical antigen presentation in lung cancer

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative The proposed research is relevant to public health because it is focused on understanding tumor occurrence, metastasis, and connection with brain development of medulloblastoma, the most malignant brain cancer in childhood. The proposed research has the potential for a significant advance in the development of novel treatment options for this devastating pediatric brain cancer, which pertains to the NIH mission of reducing death and illness in children's health care.

PI_NAMEs: HU, BAOLI  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Activator Appliances;Biological Models;Biology;Brain;Brain Neoplasms;cancer therapy;cell motility;Cells;Cerebellum;Cessation of life;chemotherapy;Child;Child health care;Childhood;Childhood Malignant Brain Tumor;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Clinical;Common Neoplasm;conditional knockout;conventional therapy;Data;Development;disabled;effective therapy;Enhancers;Epigenetic Process;epigenomics;Excision;Family;Functional disorder;Gene Family;gene regulatory network;gene repression;Genes;Genetic;Genetic Transcription;Genetically Engineered Mouse;high risk;Homologous Gene;improved;In Vitro;in vivo;innovation;Innovative Therapy;Intervention;Knockout Mice;Knowledge;loss of function;Malignant - descriptor;Malignant neoplasm of brain;Mediating;Medulloblastoma;medulloblastoma cell line;Methods;Mission;Modeling;Molecular;Morbidity - disease rate;mouse model;Mus;Mutation;MYC gene;Names;Neoplasm Metastasis;nerve stem cell;neurodevelopment;novel;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Outcome;overexpression;Pathologic;Pathway interactions;Patient-Focused Outcomes;Patients;pharmacologic;Phenotype;pre-clinical;Pre-Clinical Model;prevent;Prognosis;programs;Protein-Lysine 6-Oxidase;Public Health;Publishing;Purkinje Cells;Radiation therapy;Regulation;Regulatory Element;Relapse;Repression;Research;Role;SHH gene;Signal Pathway;Signal Transduction;SMARCD3 gene;src-Family Kinases;Subgroup;Testing;Therapeutic Trials;therapeutically effective;TP53 gene;Transcription Coactivator;Transcriptional Regulation;transcriptomics;tumor;Tumor Promotion;Tumor Suppressor Genes;tumorigenesis;United States National Institutes of Health;Up-Regulation;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Role of SMARCD3/BAF60C in medulloblastoma

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: AI

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: BERKELEY

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative  QS-21 is an adjuvant sourced from the Chilean soapbark tree (Quillaja saponaria) that is utilized in four FDA-approved vaccines; however, current methods to improve its immunogenicity by diversifying its molecular structure (i.e., plant biosynthesis or chemical synthesis) and learning structure-activity relationships are limited. Our extraordinary discovery that yeast (Saccharomyces cerevisiae) can be engineered to produce QS-21 from simple sugars and our extensive experience characterizing the immunogenic profiles of small molecules like QS- 21 uniquely position us to design improved QS-21 analogs. Herein, we propose to engineer adjuvants by iteratively diversifying their molecular structures (synthetic biology) and discovering their molecular-level immunogenic mechanisms (systems-level immunology), enabling the design and deployment of best-in-class adjuvants that transform the treatment and prevention of disease.

PI_NAMEs: KEASLING, JAY D (contact);MUKUNDAN, HARSHINI

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Address;Adjuvant;Aluminum;Anabolism;analog;Antigens;Bacterial Antigens;Bioinformatics;chemical synthesis;Chemicals;Chilean;Collaborations;combinatorial;Computer Models;CPG-oligonucleotide;Derivation procedure;design;Disease;disorder prevention;Dose;Emulsions;Engineering;Ensure;enzyme substrate;Enzymes;experience;FDA approved;Future;Genetic Engineering;glycosyltransferase;Goals;Homologous Gene;Human;immune activation;Immune response;Immunity;immunogenic;immunogenicity;Immunologics;Immunologist;Immunology;improved;In Vitro;in vivo;innovation;interdisciplinary approach;iterative design;Knowledge;Laboratories;Learning;Length;Measures;Mediating;metabolic engineering;Methods;microbial;microorganism;Modeling;Molecular;Molecular Structure;mouse model;Nature;Oils;Organism;Pathway interactions;pharmacophore;Physiological;Plant Genome;Plants;Positioning Attribute;Prevention;Process;Production;Property;Proteins;Proteomics;Protocols documentation;QS21;rapid growth;Saccharomyces cerevisiae;Salts;screening;small molecule;Soapbush;Source;Structure-Activity Relationship;success;sugar;Surveys;synthetic biology;System;Toxic effect;transcriptome;transcriptomics;Trees;Vaccine Antigen;vaccine efficacy;vaccine immunogenicity;Vaccines;Viral;Viral Antigens;Water;Work;Yeasts

PROJECT_TITLE: Iterative Microbial Production and Systems Immunology to Design QS-21 Adjuvants

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Gene Therapy;Genetics;Heart Disease;Orphan Drug;Pediatric;Rare Diseases

PHR: PROJECT NARRATIVE Loss-of-function mutations in ALPK3 result in human cardiomyopathy. Currently, there are no specific treatments available for patients diagnosed with ALPK3 cardiomyopathy. We propose to use gene replacement therapy to deliver a functional, mini-ALPK3 variant, which can be packed into an adeno-associated virus vector, to rescue heart abnormalities in a mouse model of progressive cardiomyopathy.

PI_NAMEs: CHEN, JU  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Address;adeno-associated viral vector;Adult;Age Months;Alleles;Amino Acids;Animal Model;Base Pairing;Birth;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiovascular Diseases;Code;cohort;Compensation;Complementary DNA;coronary fibrosis;Data;Databases;Dependovirus;design;Development;Diagnosis;Dilated Cardiomyopathy;early childhood;early onset;effective therapy;Exhibits;Exons;Family;gene replacement;gene replacement therapy;gene therapy;Genes;Genetic Materials;Goals;Heart;Heart Abnormalities;Heart failure;heart function;Heterozygote;Human;human disease;Hypertrophic Cardiomyopathy;in vivo;Individual;insight;Knockout Mice;Length;loss of function;loss of function mutation;Loss of Heterozygosity;Methods;Molecular;mouse model;Mus;Muscle;Mutation;Myocardium;Names;novel;Pathogenicity;Pathologic;Patients;Phenotype;Phosphotransferases;Play;postnatal;premature;Premature Mortality;prevent;Protein Kinase;Research;Role;Therapeutic;Time;treatment strategy;Variant;Viral Packaging;Viral Vector

PROJECT_TITLE: Gene Therapy for ALPK3 Cardiomyopathy Using MiniALPK3

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Primary Health Care;Telehealth

ORG_CITY: MINNEAPOLIS

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE The proposed research is relevant to public health because it tests innovative strategies to increase the reach and accessibility of a parent-focused prevention program, delivered to parents who are referred to the program by primary care clinicians. This study will produce knowledge that can inform research efforts, clinical care, and policy efforts to increase accessibility to evidence-based parenting support through the highly accessed service setting of primary care. Increased accessibility of effective parenting programs can prevent future mental illness and foster healthy development at a population level.

PI_NAMEs: MEHUS, CHRISTOPHER J (contact)

PROGRAM_OFFICER_NAME: ROONEY, MARY

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent;Age;arm;Behavioral;behavioral health;behavioral outcome;Child;Child Care;Child Rearing;Childhood;Clinic;Clinical;clinical care;Communication;Communities;Consumer Price Index;cost;Cost Analysis;Cost-Benefit Analysis;Costs and Benefits;Criminal Justice;design;Development;Directories;Disease;Economics;education cost;effective intervention;Effectiveness;effectiveness testing;eHealth;empowerment;evidence base;Fostering;Funding;Future;Generations;Goals;Health Benefit;Healthcare;innovation;Investments;Knowledge;Link;Marketing;Measures;Mental Depression;Mental disorders;Monte Carlo Method;Morbidity - disease rate;mortality;National Institute of Mental Health;Outcome;parenting intervention;Parents;Participant;Patients;pediatric patients;Persons;pilot test;Policies;Population;prevent;Prevention program;preventive intervention;Primary Care;primary care clinic;primary care clinician;primary care setting;Process;programs;provider communication;Public Health;Randomized;randomized trial;Randomized, Controlled Trials;Research;Research Design;Sampling;service delivery;Service setting;skills;Societies;System;Testing;Time;Training;Training Programs;Uncertainty;video chat;Visit;Writing;Youth

PROJECT_TITLE: Testing a brief eHealth parent-focused prevention intervention with parents referred from primary care clinics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (90)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Complementary and Integrative Health;Machine Learning and Artificial Intelligence;Natural Products;Networking and Information Technology R&D (NITRD)

ORG_CITY: Nashville

ORG_DEPT: CHEMISTRY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative. The parent award involves the development and application of machine learning methods that can be used to prioritize natural products with therapeutically relevant bioactivities and provide insight into natural product structure activity relationships. One strategy for bioactive natural product discovery currently being pursued by a graduate student working on this project, Adrian Russ, is to apply our machine learning-guided genome mining to understudied taxa of bacteria that are more likely to produce novel compounds. This supplement will support Adrian’s research project and career development.

PI_NAMEs: WALKER, ALLISON SARA (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Analytical Chemistry;Award;Bacteria;Bacterial natural products;bioactive natural products;Bioinformatics;career;career development;Chemical Structure;Dedications;Development;fascinate;Funding;fungus;Genome;graduate student;insight;interest;Learning;Machine Learning;machine learning method;Metabolism;Microbiology;Mining;Molecular Biology;Natural product discovery;Natural Products;novel;parent project;Plants;Research;Research Project Grants;response;secondary metabolite;Source;Streptomyces;Structure-Activity Relationship;symposium;Techniques;Therapeutic;Time;Training;Travel;Work

PROJECT_TITLE: Machine learning approaches for the discovery, repurposing, and optimization of natural products with therapeutic potential - Supplement to support grad training of Adrian Russ


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

PHR: Project Narrative Although astrocytes are key components of brain circuits underlying voluntary behaviors and proposed an important layer of regulating social behaviors, yet the underlying mechanisms are poorly understood. We will investigate astrocyte and neuron interactions in regulating social novelty recognition that involve glutamatergic signaling using multi-layered cutting edge experimental evaluation with computational approaches. At its conclusion, this work will illuminate novel targets that can reduce the devastating social behavior-related psychiatric and medical consequences such as autism spectrum disorder.

PI_NAMEs: KANG, SEUNGWOO  (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TERMS: Affect;Animal Behavior;Animal Model;ASD patient;Astrocytes;autism spectrum disorder;Autopsy;Behavior;behavior prediction;Behavioral;behavioral deficiency;behavioral outcome;Brain;brain abnormalities;Brain region;brain tissue;Calcium;Calcium Signaling;Cell Communication;cell type;Characteristics;Communication;Complex;conditional knockout;Development;Diagnosis;Disease;Electrophysiology (science);Etiology;Evaluation;Event;Exhibits;Fiber;Functional disorder;Genes;Genetic;Glutamate Transporter;glutamatergic signaling;Glutamates;Human;Impairment;in vivo;Individual;induced pluripotent stem cell;Knowledge;Machine Learning;Magnetic Resonance Spectroscopy;Maintenance;Measures;Mediating;Medical;Mental disorders;Metabolism;Methods;Microscopy;miniaturize;model of autism spectrum disorder;Molecular Abnormality;Nervous System Disorder;neural circuit;Neuroglia;Neurons;neurotransmission;novel;novel therapeutics;overexpression;Pattern;Phenotype;Photometry;Predictive Factor;Process;Regulation;Reporting;Research;response;Role;sensor;Signal Transduction;social;Social Behavior;social communication impairment;Social Controls;Social Environment;spatiotemporal;Stimulus;Structure of paraventricular nucleus of thalamus;Synapses;Synaptic Cleft;synaptic function;System;transmission process;Work

PROJECT_TITLE: Astrocyte-neuron mechanisms of glutamatergic modulation in social novelty recognition

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Climate-Related Exposures and Conditions;Genetics;Human Genome;Immunotherapy;Skin Cancer

ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

ORG_STATE: NH

PHR: Nras-mutated melanomas are difficult to treat and in need of improved therapies. We perform studies to understand how Nras mutations, PDL1 and UVB interact in sunlight exposure-associated melanomas and how these affect tumor progression, metastases and treatment resistance. Understanding mechanisms of how PDL1 affects UVB-driven melanomas and treatment resistance will help improve therapies.

PI_NAMEs: CURIEL, TYLER J. (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Acute;Adoptive Cell Transfers;Affect;anti-CTLA4;ATAC-seq;Benign;Bioinformatics;Biological Assay;Cancer Model;Cell Communication;Cells;Cleavage Under Targets and Release Using Nuclease;confocal imaging;Cutaneous;Cytometry;Data;Data Set;Distant;draining lymph node;Effector Cell;Engineering;Epigenetic Process;Erythema;Evolution;Flow Cytometry;Follow-Up Studies;Frequencies;Genetic;Genetic Engineering;Growth;Heritability;Human;human data;human tissue;Image;imaging approach;Immune;immune checkpoint blockade;Immunity;immunodeficiency;immunoengineering;Immunologic Surveillance;improved;Inflammatory;inhibitor;insight;Interferons;Logistics;Lung;Malignant Neoplasms;Mediating;melanocyte;Melanoma;Melanoma Cell;Melanoma Tumor;melanomagenesis;Memory;Modeling;mouse model;Mus;mutant;Mutate;Mutation;neoplasm immunotherapy;Neoplasm Metastasis;Neoplasm Transplantation;neoplastic cell;novel;Outcome;Pathway interactions;prevent;Production;programmed cell death ligand 1;programmed cell death protein 1;Proteins;receptor;Reporter;Reporter Genes;Risk;Signal Transduction;single-cell RNA sequencing;Site;small molecule inhibitor;Statistical Methods;Sun Exposure;Surface;Tamoxifen;Testing;therapy resistant;trafficking;transcriptome sequencing;translational potential;Transplantation;treatment response;tumor;Tumor Immunity;tumor immunology;tumor progression;Tumor-Derived;UV induced;UV-induced Melanoma

PROJECT_TITLE: Melanocyte PDL1 control of UVB-induced IFN-I

STUDY_SECTION: TIR

STUDY_SECTION_NAME: Therapeutic Immune Regulation Study Section[TIR]


NIH_SPENDING_CATS: Cancer;Genetics;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

PHR: Narrative Osteosarcoma is a extremely aggressive bone tumor with a high propensity to metastasize, which is associated with an extremely poor prognosis and thus in dire need of more effective targeted therapies. However, with the incorporation of novel mono-therapeutic agents directed at targeting relapsed and metastatic disease, there is a high propensity for the development of resistance. Thus, the identification of molecular mechanisms of resistance and rational, synergistic combination therapies is particularly relevant to the NIH’s mission toward the identification of novel therapeutic interventions that can be implemented to prevent and treat this highly aggressive pediatric cancer.

PI_NAMEs: YUSTEIN, JASON  (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: Apoptosis;Atlases;Bar Codes;beta catenin;Binding;Bioinformatics;Biological Assay;bone;Bone neoplasms;Cancer Patient;Caring;Cell Communication;Cell Line;Cell membrane;Cell Physiology;Cells;Chemoresistance;Childhood;Childhood Solid Neoplasm;clinical application;Clinical Treatment;Clinical Trials Design;Clonal Evolution;combinatorial;Combined Modality Therapy;Complex;Cytotoxic T-Lymphocytes;Development;Disease;Drug Combinations;Drug Screening;efficacy evaluation;Equipment and supply inventories;Evolution;Exclusion;Family member;FDA approved;Future;Genes;Genetic;Genetic Transcription;Genetically Engineered Mouse;Growth;high risk;high-throughput drug screening;Histone Deacetylase;Human;Immune;immune cell infiltrate;improved;In Vitro;in vivo;in vivo Model;Infiltration;Infrastructure;inhibitor;Injections;insight;Invaded;Lung;lung metastatic;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;Metastatic Neoplasm to the Lung;migration;Mission;Modeling;Molecular;Molecular Profiling;mouse model;Mus;Natural Killer Cells;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;novel therapeutics;Nuclear;Osteosarcoma;Outcome;overexpression;Pathway interactions;Patient Care;patient derived xenograft model;patient population;patient prognosis;Patients;pharmacologic;Phase;Phase I/II Clinical Trial;Phenotype;Physiological;Population;pre-clinical;Preclinical Testing;prevent;Prognosis;Proliferating;Proteins;Recurrent disease;Refractory;Regimen;Relapse;Reporting;Resistance;Resistance development;resistance mechanism;response;Role;Sarcoma;Signal Transduction;single-cell RNA sequencing;small molecule inhibitor;stemness;Survival Rate;Tail;targeted treatment;Therapeutic;Therapeutic Clinical Trial;Therapeutic Intervention;Toxic effect;Transcription Coactivator;transcriptomics;Translating;treatment response;tumor;tumor growth;tumor initiation;tumor microenvironment;tumor-immune system interactions;tumorigenesis;Tyrosine Kinase Inhibitor;United States National Institutes of Health;Veins;WNT Signaling Pathway

PROJECT_TITLE: Identifying and overcoming mechanisms of resistance to effectively target the TBL1/β-catenin signaling axis for high-risk osteosarcoma

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


NIH_SPENDING_CATS: Aging;Bioengineering;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: IOWA CITY

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE  The proposed research is relevant to public health because it focuses on understanding the underlying mechanisms that cause or worsen age-related macular degeneration (AMD), a common form of blinding eye disease. The results of the proposed research are expected to enable identification of novel therapeutic strategies to reduce sub-retinal fibrosis and inflammation, which are not addressed by current AMD treatments. This project is well-aligned with the NEI’s mission because it is a cutting-edge research project that will enhance understanding of AMD pathophysiology and has strong potential to catalyze advancements in the prevention and treatment of AMD.

PI_NAMEs: WORTHINGTON, KRISTAN SORENSON (contact)

PROJECT_TERMS: Acceleration;Address;Age;Age related macular degeneration;Aging;Atomic Force Microscopy;base;Biomechanics;Blood Vessels;cell dedifferentiation;Cell-Cell Adhesion;Cells;Characteristics;Choroid;combinatorial;Complex;design;Developed Countries;Development;Disease;Disease Progression;donor stem cell;druggable target;Early treatment;Elasticity;Endothelial Cells;Endothelium;Engineering;epithelial to mesenchymal transition;Epithelium;Extracellular Matrix;Eye diseases;Family suidae;Fibrosis;Foundations;Functional disorder;Gelatin;Genetic;Genetic Polymorphism;Genetic Risk;genetic risk factor;Goals;High Prevalence;high risk;Human;Human body;human induced pluripotent stem cells;Hydrogels;Hypertension;Image;Immunofluorescence Immunologic;In Situ;In Vitro;Inflammation;innovation;Intervention;Knowledge;Life Style;Maps;Mechanics;mechanotransduction;Mesenchymal;migration;Mission;Molecular;Monitor;Morphology;novel;novel strategies;novel therapeutic intervention;Outcome;Pathologic;Pathway interactions;pharmacologic;Phenotype;Play;preclinical development;Prevention;Proliferating;Property;Prophylactic treatment;Proteins;Public Health;Recording of previous events;Reporting;Research;Research Project Grants;response;Retina;Retinal Degeneration;rho;Risk Factors;risk variant;Role;Signal Pathway;Signal Transduction Pathway;single-cell RNA sequencing;Smoking;Solid;Structure of retinal pigment epithelium;System;Testing;Therapeutic;therapeutically effective;tissue culture;Tissue Engineering;Tissue Model;Tissues;transdifferentiation

PROJECT_TITLE: Role of Matrix Stiffness and Genetic Risk Factors in AMD-Associated Epithelial-to-Mesenchymal Transition


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Pain Research;Substance Misuse;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_DEPT: ANESTHESIOLOGY

PHR: Project Narrative Individuals with chronic temporomandibular disorder (TMD) pain are at increased risk for alcohol-related consequences compared to those without pain, and growing evidence suggests pain is a potent motivator for alcohol use in many individuals. However, few systematic examinations of modifiable and non-modifiable risk factors, including orofacial pain status, have been conducted. This project addresses this gap in knowledge by determining the effect of pain on drinking topography in heavy drinkers with and without chronic TMD pain in both the laboratory and daily life.

PI_NAMEs: BOISSONEAULT, JEFFREY B (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Absence of pain sensation;Acute;Address;Adult;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol related consequences;alcohol risk;alcohol use disorder;Alcohol withdrawal syndrome;Alcoholic beverage heavy drinker;Alcohols;Analgesics;Anxiety;base;Behavior;Blood alcohol level measurement;breath alcohol measurement;Chronic;chronic pain;chronic pain management;chronic pain patient;chronic painful condition;Communities;Consumption;debilitating pain;drinking;drinking behavior;driving behavior;Drunk driving;Ecological momentary assessment;Environment;Event;Expectancy;experimental study;Functional disorder;General Population;Goals;hangover;Heavy Drinking;high risk drinking;Hyperalgesia;Impairment;Impulsivity;Individual;insight;Intervention;Investigation;Jaw;Knowledge;Laboratories;Life;Literature;Mediating;Mediation;Methods;Modeling;Muscle;negative affect;neurobehavioral;Nonpharmacologic Therapy;Opioid Analgesics;Orofacial Pain;Pain;Pain intensity;Pain management;pain relief;pain self-management;pain sensitivity;Patients;Pattern;Persons;Play;Predictive Factor;Predisposition;psychosocial;Psychosocial Factor;Reporting;Reproducibility;Risk;Risk Factors;Role;Self Management;Self Medication;Severities;Structure;substance use;Temporomandibular Joint;Temporomandibular joint disorder pain;Temporomandibular Joint Disorders;Testing;Time;virtual reality;Work

PROJECT_TITLE: Effects of Pain on Laboratory Drinking Topography and Daily Drinking in People with Chronic TMD Pain

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Clinical Research;Health Services;Lung;Machine Learning and Artificial Intelligence;Primary Health Care;Sleep Research

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Obstructive sleep apnea (OSA) is a very common condition that is associated with significant health problems. This study will assess the rate of underdiagnosis of OSA in primary care practices, determine the factors that lead to underdiagnosis, and also develop a more efficient way to identify OSA in primary care practices using sophisticated computerized techniques using data from electronic medical records.

PI_NAMEs: MAGALANG, ULYSSES J (contact);PACK, ALLAN I

PROGRAM_OFFICER_NAME: BROWN, MARISHKA

PROJECT_TERMS: Address;Adoption;adverse outcome;Affect;automated algorithm;Awareness;cardiovascular risk factor;Cardiovascular system;Clinical;clinically relevant;clinically significant;comorbidity;computerized;Computerized Medical Record;Data;Development;Diagnosis;Diagnostic;Disease;Drowsiness;Economics;electronic data;electronic health data;Electronic Health Record;Engineering;Event;Failure;Frequencies;Future;Growth;Health;High Prevalence;Home;Individual;insight;International Classification of Disease Codes;Intervention;Knowledge;Machine Learning;machine learning algorithm;machine learning pipeline;Medical Care Costs;men;Methods;Midlife women;mortality;novel;Obstructive Sleep Apnea;Office Visits;Outpatients;Patient Recruitments;patient subsets;Patients;Perception;Persons;Phenotype;Physicians;Population;positive airway pressure;practice setting;Prevalence;Primary Care;primary care clinic;primary care practice;primary care provider;primary care setting;Process;Public Health;Reporting;Reproducibility;Risk;Risk Assessment;Safety;Sampling;Sleep;Sleep Apnea Syndromes;Sleep disturbances;Sleeplessness;Structure;Surveys;Symptoms;System;Techniques;Testing;Time;tool;treatment comparison;United States;Validation;Work

PROJECT_TITLE: Undiagnosed Obstructive Sleep Apnea in Primary Care Clinics

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Bioengineering;Biotechnology;Congenital Structural Anomalies;Genetics;Nanotechnology;Pediatric;Rare Diseases;Rheumatoid Arthritis

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Rheumatoid arthritis (RA) is a serious autoimmune and inflammatory disease affecting 1% of the world's population. The proposed project aims to understand how INPP5E influences RA pathogenesis and test a new treatment using novel targeted lipid nanoparticles to deliver INPP5E mRNA in RA mouse models. We expect that this study will bring novel insights into the mechanism of RA pathogenesis and provide a new mRNA therapy for RA and other inflammatory diseases.

PI_NAMEs: YANG, SHUYING  (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Ablation;Acute;Affect;AKT Signaling Pathway;Anti-Inflammatory Agents;Antibodies;antibody conjugate;arthropathies;Attenuated;aurora kinase A;Autoimmune Diseases;Behavior;Biological Response Modifier Therapy;bone;bone erosion;brain malformation;Cell Physiology;Cell Proliferation;cell type;Chronic;Clinic;collagen antibody induced arthritis;Collagen Type II;cytokine;Data;Databases;Deterioration;Disease;Disease Management;Disease-Modifying Second-Line Drugs;DNA Damage;DNA Repair;drug candidate;Economic Burden;effective therapy;Embryonic Development;factor A;functional disability;Human;IL6 gene;Immune response;Immune system;Inflammation;Inflammatory;Inflammatory Response;inositol-1,4,5-trisphosphate 5-phosphatase;insight;intense pain;Interleukin-1;Joints;Joubert syndrome;lipid nanoparticle;Macrophage;Mass Spectrum Analysis;Meckel-Gruber syndrome;Mediating;Messenger RNA;Methotrexate;Microphthalmos;Modeling;Monoclonal Antibodies;mouse model;mRNA delivery;Mus;Mutation;nanoparticle;nanoparticle delivery;Nervous System Physiology;novel;Osteoclasts;overexpression;Oxidation-Reduction;Pain;Pathogenesis;Patients;Phagocytosis;Phenotype;phosphoinositide-3,4,5-triphosphate;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphorylation Inhibition;Physiological;PI3K/AKT;Play;Population;Primary Cell Cultures;Protein Dephosphorylation;Proteins;Proteomics;Proto-Oncogene Proteins c-akt;Refractory;Rheumatoid Arthritis;RNA Interference;Role;Safety;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Situs Inversus;skeletal abnormality;socioeconomics;Source;Specificity;targeted delivery;Technology;Testing;Tissues;TNF gene;transcription factor

PROJECT_TITLE: INPP5E Signaling and Treatment in Rheumatoid Arthritis

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative: The high salt diet stimulates the production of sphingosine-1-phosphate (S1P) in the kidneys to increase the excretion of extra sodium load. Acid ceramidase is the key enzyme to produce S1P and inhibited in mice with high blood pressure. Enhancing the function of acid ceramidase can be a new therapeutic strategy for the treatment of salt-sensitive high blood pressure.

PI_NAMEs: LI, NINGJUN  (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: Acetates;Anti-Hypertensive Agents;Binding;Blood Pressure;blood pressure control;Body System;brain tissue;Cell Physiology;Cells;Ceramidase;Ceramides;Data;Deoxycorticosterone;Development;Disease;Diuretics;Duct (organ) structure;Enzymes;Excretory function;Family;Farber's lipogranulomatosis;G-Protein-Coupled Receptors;galactosylgalactosylglucosylceramidase;Generations;high salt diet;Homeostasis;Hydrolysis;Hypertension;hypertensive;Impairment;Infusion procedures;inhibitor;insight;ischemic injury;Kidney;Kidney Diseases;kidney medulla;Knock-out;Lipids;Lung;Lymphoid;Mediating;member;Modeling;Molecular;Mus;novel;novel therapeutic intervention;Pathogenesis;Pathway interactions;Phosphorylation;Play;Production;promoter;protective effect;Protein Isoforms;Proteins;receptor;Regulation;renal ischemia;response;Role;salt intake;salt sensitive;salt sensitive hypertension;saluretic;Signal Pathway;Signal Transduction;Signaling Molecule;small hairpin RNA;Sodium;Sodium Chloride;Sphingolipids;Sphingosine;sphingosine 1-phosphate;sphingosine kinase;Sphingosine-1-Phosphate Receptor;System;Testing;text searching;transcription factor;Transfection;treatment strategy;Tubular formation

PROJECT_TITLE: Renal acid ceramidase-S1P pathway in salt-sensitive hypertension

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative The proposed research will identify genes and their cell types of action driving human disease across global populations, revealing clinically relevant candidate biomarkers and drug targets while enhancing the equity of biomedical discovery. This project is relevant to the mission of the NIH because it provides a stellar return on the investment of millions of dollars allocated to variant-to-function studies by providing statistical methodology to comprehensively elucidate the functional mechanisms of disease-associated genetic variation.

PI_NAMEs: AMARIUTA-BARTELL, TIFFANY  (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: 3-Dimensional;Acceleration;Accounting;Address;Algorithms;Autoimmune Diseases;Automobile Driving;Behavior;Benchmarking;Binding;candidate marker;causal variant;Cell Physiology;cell type;Cells;Chromosome Mapping;Clinical;clinically relevant;cohort;Complex;Data;Dedications;Disease;Distal;DNA;Drug Targeting;Epigenetic Process;Equity;European;feature selection;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;Genes;Genetic;genetic analysis;genetic association;Genetic Models;genetic variant;Genetic Variation;genome wide association study;genome-wide;genomic locus;Genotype;Germ Lines;Heritability;high dimensionality;human disease;improved;Individual;innovation;insight;Intervention;Investments;Linear Regressions;Link;MAPK3 gene;Maps;Measures;Mediating;Methodology;Methods;Minority;Mission;Modeling;Neurons;novel;Nucleic Acid Regulatory Sequences;Persons;Phenotype;polygenic risk score;Population;predictive modeling;Predictive Value;Proliferating;Publishing;Quantitative Trait Loci;Regulation;Regulatory Element;Research;Research Design;Risk;RNA Splicing;Sample Size;Schizophrenia;single-cell RNA sequencing;statistics;Techniques;therapeutic development;Time;Tissues;tool;trait;transcription factor;transcriptome;transcriptomics;United States National Institutes of Health;Untranslated RNA;Variant;Work

PROJECT_TITLE: Identifying ancestry-specific and distal components of disease-associated gene regulation and cellular function

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Services;Mental Health;Mental Illness;Pediatric;Primary Health Care;Social Determinants of Health

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

ORG_STATE: NC

PHR: PROJECT NARRATIVE Anxiety disorders among youth are extremely common and without effective treatment can lead to depression, substance use, suicide, and deficits in functioning into adulthood. Although pediatric anxiety interventions, such as cognitive behavioral therapy and antidepressant medications, are highly efficacious, many clinicians are under-using these evidence-based treatments. We will develop and test two complementary casemix-adjusted pediatric anxiety outcome quality measures using the GAD-7 instrument: (1) a measure of whether patients are responding to treatment (treatment response) and (2) a whether patients’ anxiety remitted (remission), which will provide a critical tool for improving outcomes from anxiety treatment.

PI_NAMEs: MARK, TAMI L (contact);SAAVEDRA, LISSETTE MARIA

PROGRAM_OFFICER_NAME: HUMENSKY, JENNIFER L

PROJECT_TERMS: Adult;Aftercare;Age;anti-depressive agents;Anxiety;Anxiety Disorders;anxiety symptoms;anxiety treatment;Australia;California;Caring;case control;Case Mixes;Case-Mix Adjustments;Childhood;childhood anxiety;Chronic;Clinic;Cognitive Therapy;Computerized Medical Record;Data;Databases;Development;Disease;Disease remission;effective therapy;electronic medical record system;England;ethnic minority population;Ethnic Origin;Evidence based treatment;Foundations;Goals;Health;health plan;Health system;Healthcare Systems;Hospitals;implementation barriers;improved;improved outcome;indexing;instrument;International;Intervention;Interview;Investments;Link;Measurement;Measures;Medical;medical specialties;Mental Depression;Mental Health;Mental Health Services;Monitor;National Institute of Mental Health;Northern Ireland;Norway;Outcome;Outcome Measure;Pathological anxiety;patient population;Patients;pediatric patients;Pharmaceutical Preparations;Population;primary care clinician;primary care provider;Process;Provider;Psychometrics;Questionnaires;Race;racial minority;Reporting;Research;Resources;response;Risk;Risk Factors;Sampling;social;social health determinants;substance use;Suicide;Symptoms;Testing;Time;tool;treatment of anxiety disorders;Treatment outcome;treatment response;United States;usability;Validation;Vendor;Youth

PROJECT_TITLE: Development and Testing of a Pediatric Anxiety Outcomes Quality Measure (PAO_QM Study)

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-N (05)]


PHR: Public Relevance Statement This project will evaluate the causative role of a glycosaminoglycan in mediating prostatic hyperplasia, and fibrosis in benign prostatic hyperplasia (BPH), a disease afflicting aging men. It will test the efficacy of a glycosaminoglycan inhibitor with excellent safety profile while evaluating if patients’ symptom score is a surrogate for its use.

PI_NAMEs: LOKESHWAR, BAL L;LOKESHWAR, VINATA B (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: 4-methylumbelliferone;Affect;age related;Aging;Applications Grants;associated symptom;Benign Prostatic Hypertrophy;Biological Availability;Budgets;Categories;Cells;Chronic;Clinic;Clinical;clinically relevant;clinically significant;cytokine;Data;Disease;drug repurposing;Duct (organ) structure;efficacy testing;Evaluation;experimental study;Family;Family member;Fibrosis;Future;Glycosaminoglycans;Goals;Growth Factor;Human;Hyaluronic Acid;Hyperplasia;immune cell infiltrate;immunocytochemistry;In Vitro;in vivo Model;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;International;Link;lower urinary tract symptoms;Mediating;Medical;men;Modeling;Morphogenesis;mouse model;Operative Surgical Procedures;Oral;Pathologic;Pathology;patient stratification;Patients;Pattern;Pharmaceutical Preparations;Pre-Clinical Model;prevent;Procedures;Prostate;Prostatic hypertrophy;Role;Safety;Sample Size;side effect;Signal Transduction;single-cell RNA sequencing;Site;Specimen;Statistical Data Interpretation;symptomatic improvement;Symptoms;System;Testing;Therapeutic;Time;Tissues;Toxic effect;Work

PROJECT_TITLE: Glycosaminoglycan Targeting Treatment for Prostatic Hyperplasia and Fibrosis

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Neurosciences;Patient Safety;Urologic Diseases

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Narrative Existing devices to stimulate the posterior tibial nerve to treat overactive bladder either require frequent clinical visits or utilize complicated and expensive implantable devices placed many millimeters or even centimeters from the targeted nerve. This leads to inconsistent activation of the posterior tibial nerve, as well as device related adverse events. In this study, we will develop a novel minimally invasive electrode strategy consisting of only 2 implanted passive materials, and an associated surgical tool that allows for direct targeting of the nerve to improve nerve engagement while reducing complications.

PI_NAMEs: LUDWIG, KIP A (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: 3-Dimensional;Address;Adverse event;Affect;Anatomy;Ankle;Arteries;Bladder;Cadaver;Chronic;Chronic pain syndrome;Clinical;cohort;Complex;Computer Models;Connective Tissue;cost;Data;Data Set;Defect;design;Development;Devices;Diameter;efficacy testing;Elastic Tissue;Electrodes;Electromyography;Encapsulated;Engineering;Excision;Exercise;Failure;Family suidae;FDA approved;Fiber;flexibility;Geometry;Histologic;Human;Image;Imaging Techniques;Implant;implant material;implantable device;improved;Incontinence;Individual;Injectable;Injections;Lead;Life Style Modification;Location;Marketing;Measurement;Mediating;micturition urgency;migration;millimeter;Miniature Swine;minimally invasive;Modeling;Movement;Muscarinics;Muscle;Nerve;Nerve compression syndrome;neural;neurovascular;next generation;Nociception;Nocturia;novel;Operative Surgical Procedures;Optical Coherence Tomography;optical fiber;Overactive Bladder;Pelvic floor structure;Peripheral Nerve Stimulation;Peripheral Nerves;pharmacologic;Posterior Tibial Nerves;pressure;Prevalence;Procedures;Process;Puncture procedure;Quality of life;Refractory;response;safety testing;Sampling;Sensory;side effect;Structure;Structure of tibial nerve;supply chain;Testing;Therapeutic;Tissues;tool;Training;Transcutaneous Electric Nerve Stimulation;Trauma;Urine;Veins;Visit;Woman;Women's prevalence

PROJECT_TITLE: An Injectable Electrode to Better Isolate the Posterior Tibial Nerve to Treat OAB

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Pediatric;Prevention;Primary Health Care;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research

ORG_CITY: GAINESVILLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Autistic people have significantly heightened risk of suicide deaths and suicide behavior (SB), yet there is limited understanding of mutable factors related to risk of SB for the autistic population. There is a significant need to understand how interdependent individual, community, and policy factors influence risk of SB and mental health service receipt to contribute to the long-term goal of reducing risk of SB for the autistic population. In collaboration with an established team of autistic stakeholders and policy and practice experts, this project will identify and characterize multilevel, socioecological factors associated with risk of SB and receipt of mental health services among autistic people, and generate evidence-based, community-supported recommendations for suicide prevention.

PI_NAMEs: JACOBS, MOLLY MARIE;KIRBY, ANNE V;KRAMER, JESSICA MARVELLE;MARLOW, NICOLE M. (contact)

PROGRAM_OFFICER_NAME: LUSHIN, VICTOR

PROJECT_TERMS: adolescent with autism spectrum disorder;adult with autism spectrum disorder;Affect;Age;aged;American;Area;autism spectrum disorder;autistic;autistic behaviour;Behavioral;Biological;Characteristics;Cluster Analysis;Code;Collaborations;Communication;Communities;community consultation;Coupled;Data;Data Collection;data reduction;Databases;design;Development;Dose;econometrics;Epidemiology;evidence base;experience;Family Caregiver;Family member;Feeling suicidal;Focus Groups;Frequencies;General Population;Goals;health care availability;health care delivery;Health Legislation;Health Personnel;Health Policy;Health Resources;Healthcare;high risk population;improved;indexing;Individual;individuals with autism spectrum disorder;Language;Logistic Regressions;longitudinal dataset;Medicaid;Medical;member;Mental Health;Mental Health Services;mental state;Methods;Modality;Modeling;multilevel analysis;National Institute of Mental Health;Outcome;Participant;Persons;Pharmacology;Policies;policy recommendation;Population;preference;Principal Component Analysis;Privatization;Psychotherapy;Public Health;Recommendation;reducing suicide;Research;Resources;response;Risk Factors;Risk Reduction;Sampling;Service provision;sex;social determinants;social health determinants;social vulnerability;Strategic Planning;Substance Use Disorder;suicidal behavior;suicidal morbidity;suicidal risk;Suicide attempt;Suicide prevention;suicide rate;System;Techniques;Telemental;trait;Translations;Typology;United States Health Resources and Services Administration;Validation;Variant;virtual;Visit

PROJECT_TITLE: Socioecological Study of Autism, Suicide Risk, and Mental Health Care: Multilevel Analyses and Community Consultation for Suicide Prevention

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Genetics

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: New technologies in genomics and proteomics have revealed thousands of previously undiscovered, yet functional, microproteins encoded in the human genome. In this study, we will demonstrate that an understudied, plentiful class of microproteins that overlap known human protein coding sequences has important roles in human cells, and that their expression relies on novel mRNA mechanisms that reprogram the coding potential of human genes. This project will therefore reveal entirely new dimensions of complexity and regulation of human protein-coding genes, with important implications for human biology and disease.

PI_NAMEs: SLAVOFF, SARAH ANN (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Ablation;Alternative Splicing;Amino Acid Sequence;Ants;Apoptosis;Apoptotic;Biochemical;Biological;Biological Assay;CD95 Antigens;Cells;Cessation of life;Classification;Code;Coupled;Data;deep sequencing;Dimensions;exon skipping;Exons;experimental study;Gene Structure;Genes;Genetic Models;genomic locus;Genomics;Human;Human Biology;human disease;Human Genome;Initiator Codon;insight;Introns;Length;Maps;Messenger RNA;Methods;Modeling;Molecular;mRNA Precursor;new technology;novel;Nuclear;Open Reading Frames;Overlapping Genes;Phenotype;Play;polypeptide;Printing;Process;programs;Protein Isoforms;protein protein interaction;Proteins;Proteome;Proteomics;Reading Frames;Receptor Signaling;Regulation;Reporting;RNA Splicing;Role;Scanning;Signal Transduction;Site;Technology;Testing;Transcript;Transcription Initiation Site;transcriptome;Translating;Translation Initiation;Translations;Untranslated Regions;Untranslated RNA;Variant;Viral Genome;Work

PROJECT_TITLE: Translation of overprinted non-canonical open reading frames from alternative transcript variants

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

PHR: PROJECT NARRATIVE Ability to measure tissue oxygen levels has enormous clinical significance for reliable prognosis and treatment of several diseases, including cancer and vascular diseases. We propose to develop an innovative oxygen measurement device called OxyTrack for use in the clinic. The new device will be a valuable tool for clinical conditions where tissue oxygen is a critical variable for decision making, e.g., cancer patients and patients with diabetic peripheral vascular diseases.

PI_NAMEs: KUPPUSAMY, PERIANNAN  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, KRISTIN HEDGEPATH

PROJECT_TERMS: Animal Model;Animals;Blood;brain tissue;Cancer Patient;Canis familiaris;Cardiovascular Diseases;cerebral oxygenation;Clinic;Clinical;clinical application;Clinical Research;clinically relevant;clinically significant;comparative;Compensation;Computer software;cost;Data;data acquisition;Decision Making;design;design and construction;Detection;Development;Devices;diabetic;Diagnosis;Disease;efficacy evaluation;Electron Spin Resonance Spectroscopy;Evaluation;Fiber Optics;first-in-human;Goals;Head;Hypoxia;Implant;In Situ;In Vitro;in vivo;innovation;interest;Knowledge;magnetic field;Magnetic Resonance;Magnetic Resonance Imaging;Malignant Neoplasms;Measurement;Measures;Methods;microwave electromagnetic radiation;miniaturize;minimally invasive;Modernization;Molecular;Monitor;Mus;Needles;Neonatal;novel;Optical Methods;Oxygen;Oxygen saturation measurement;Partial Pressure;Particulate;Pathology;Patients;Performance;Peripheral Vascular Diseases;photoacoustic imaging;Physiologic pulse;portability;pre-clinical;pressure;pressure sensor;Procedures;Prognosis;Radio;Rattus;Safety;Sensitivity and Specificity;sensor;Shapes;Site;Skin;Stroke;Structure;Surface;Syringes;System;Technology;Temperature;Testing;Tissue Model;tissue phantom;Tissues;tool;transmission process;treatment site;tumor;Validation;validation studies;Vascular Diseases;wearable device;Work;wound healing

PROJECT_TITLE: Novel oxygen monitoring system for on-site use in the clinic

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Electronic Nicotine Delivery Systems;Lung;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

PHR: PROJECT NARRATIVE  Electronic nicotine delivery systems (ENDS) are used by millions of Americans, however we do not understand their long-term health effects. This research proposal will quantify the effects of long-term ENDS use on validated and novel biomarkers of cardiovascular and pulmonary disease and how they are influenced by use heaviness, age, body weight, and co-use of other products. The importance of this study does not rest upon demonstrating adverse effects of ENDS use and will produce the most informative evidence to date on how long-term ENDS use affects cardiovascular and pulmonary health.

PI_NAMEs: BAKER, TIMOTHY B (contact);STEIN, JAMES H

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: Adverse effects;Affect;Age;Air;Alcohols;American;Area;Biological Markers;Blood Glucose;Blood Pressure;Blood specimen;Body mass index;Body Weight;brachial artery;C-reactive protein;Cannabis;Carbon Monoxide;cardiometabolism;Cardiopulmonary;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;carotid intima-media thickness;Chronic;cigarette smoking;cohort;combustible cigarette;cone-beam computed tomography;Cotinine;Decision Making;Dependence;Diameter;Disease;disorder risk;electronic cigarette use;Electronic Nicotine Delivery Systems;Endothelium;Ethnic Origin;exercise capacity;Exhalation;experimental group;F2-Isoprostanes;Fasting;follow-up;Funding;Future;Gender;Glass;Glycosylated hemoglobin A;Health;Health Policy;Health Status;Heart Rate;heart rate variability;Image;indexing;Inflammation;insight;Insulin;Insulin Resistance;interest;Interleukin-6;intimal medial thickening;Learning;Link;Lipids;Long-Term Effects;Lung;Lung Diseases;lung health;marijuana use;Measures;Mediating;Methods;Morbidity - disease rate;mortality;Nicotine;Nicotine Dependence;Nitric Oxide;novel marker;Oxidative Stress;Participant;Patients;Pattern;Peroxidases;Persons;Phenotype;Physiological Processes;Policies;pressure;Probability;Public Health;Pulmonary Function Test/Forced Expiratory Volume 1;Race;Recovery;recruit;Research;Research Proposals;Residual volume;Risk;Risk Reduction;Sampling;Science;Shapes;Smoking History;Spirometry;Standardization;Stress Tests;Structure;Sympathetic Nervous System;systemic inflammatory response;Texture;Time;Tobacco smoking behavior;Tobacco-Associated Carcinogen;Total Lung Capacity;transmission process;treadmill;ultrasound;United States;urinary;waist circumference;Weight;White Blood Cell Count procedure;X-Ray Computed Tomography;Youth

PROJECT_TITLE: Longitudinal Effects of E-cigarette Use on Cardiovascular and Pulmonary Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-W (02)]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Regenerative Medicine

ORG_DEPT: DERMATOLOGY

PHR: NARRATIVE This to endothelial research Medicine understanding project implements innovative live imaging approaches, cutting-edge genetic tools, and mRNA technology investigate the regenerative potential of the corneal endothelium and to test a novel therapy for Fuchs' corneal dystrophy (FECD) using relevant animal models. The overal l goals and scope of this aligns with the mission of the of National Eye Institute and its Strategic Plan for Regenerative approaches to treat ocular disease. Knowledge generated from this study will be essential for and treating FECD and other ocular degenerative diseases.

PI_NAMEs: ROMPOLAS, PANTELEIMON  (contact);THOMASY, SARA MICHELLE

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Ablation;absorption;Acceleration;Address;Affect;Aging;Animal Model;Antibodies;Behavior;Biological Assay;Biology;Biomechanics;canine model;Canis familiaris;Cell Cycle;Cell Density;Cell Proliferation;Cell surface;Cells;Clinical;Complex;Cornea;Corneal Diseases;Corneal dystrophy;Corneal edema;Corneal Endothelium;Data;Degenerative Disorder;Descemet's membrane;Disease;disease model;disease phenotype;Disease Progression;early onset;Edema;effectiveness evaluation;efficacy testing;Elderly;Endothelial Cells;endothelial regeneration;Endothelium;Enterobacteria phage P1 Cre recombinase;Environment;epigenomics;experimental study;Eye;Eye diseases;Fuchs' Endothelial Dystrophy;Functional disorder;functional restoration;gain of function;Gene Expression;Genes;Genetic;genetic variant;Goals;Growth Factor;Human;Image;imaging approach;Impairment;in vivo;in vivo Model;Injectable;Injury;innovation;Ion Pumps;Knowledge;Label;Lasers;lipid nanoparticle;loss of function;Medicine;Messenger RNA;Methods;migration;Mission;Modeling;Molecular;Monitor;mouse genetics;mouse model;Mus;National Eye Institute;Natural regeneration;nonhuman primate;novel therapeutic intervention;novel therapeutics;Ocular Pathology;old mice;Pathogenesis;Pathway interactions;Patients;Persons;Phenotype;Physiology;preclinical development;preclinical trial;programs;Proliferating;prospective;regeneration potential;regenerative;regenerative approach;regenerative biology;Regenerative capacity;Regulation;Reporter;Research;Research Personnel;response;Role;Safety;scale up;senescence;sight restoration;Signal Pathway;single cell genomics;Specificity;stem cell population;Strategic Planning;synergism;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Intervention;Time;Tissues;tool;Translating;Treatment Protocols;two photon microscopy;uptake;Vision;Visual;wound healing

PROJECT_TITLE: Unlocking Corneal Endothelial Regeneration: Novel Therapeutic Strategies for Fuchs' Endothelial Corneal Dystrophy

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Autoimmune Disease

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE B cells can profoundly influence the immune response by expressing cytokines and co-receptors that either promote (effector B cells) or regulate (regulatory B cells) autoimmunity and anti-tumor immunity. We discovered that TIM-1 identifies B cells that possess regulatory properties by binding to phosphatidylserine expressed on apoptotic bodies. In this R01 we will determine the molecular mechanisms and transcription factors that induce Tim-1 expressing B cells with an aim to identify targets by which the regulatory properties of B cell can be manipulated to regulate autoimmunity and anti-tumor immunity.

PI_NAMEs: KUCHROO, VIJAY K. (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Address;Age;Animals;antagonist;Apoptotic;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;B cell repertoire;B-Lymphocyte Subsets;B-Lymphocytes;Binding;Biological Process;Cell Physiology;Cell surface;Cells;Colitis;conditional knockout;CRISPR screen;CXCR6 gene;cytokine;Data;Dermatitis;Disease;effector T cell;FOXP3 gene;Frequencies;Gene Expression Profile;Generations;Genetic Transcription;Granulocyte-Macrophage Colony-Stimulating Factor;Hepatitis;Homeostasis;Human;humoral immunity deficiency;IL17 gene;Immune response;Immune Tolerance;Inflammation;Inflammatory;Inflammatory Response;Interleukin-10;interleukin-23;Interleukin-6;Mediating;Meningeal;Molecular;Multiple Sclerosis;Mus;novel;novel therapeutic intervention;Organ;Outcome Assessment;Paralysed;Pathogenicity;Phenotype;phosphatidylserine receptor;Phosphatidylserines;Process;Production;Property;receptor;Regulatory T-Lymphocyte;response;Role;Self Tolerance;Spontaneous colitis;stem;stemness;Tissues;transcription factor;tumor growth;Tumor Immunity;Tumor Promotion;whole genome

PROJECT_TITLE: Role of Tim-l in B Cells in regulating autoimmunity in the CNS

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Genetics;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative Blood stem cells live in a complex microenvironment or “niche” in the bone marrow and are supported by many different types of cells. We want to understand how blood stem cells interact with niche cells when they are developing in the embryo and in adulthood. We believe defining these cellular interactions will improve our ability to make blood stem cells in the lab, and to improve outcomes for patients who receive blood stem cell transplants.

PI_NAMEs: TAMPLIN, OWEN JAMES (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Address;Adhesions;Adult;aged;Aorta;ATAC-seq;autocrine;Behavior;Binding;Biological Models;Blood;Blood Vessels;Bone Marrow;Bypass;Cell Adhesion;cell behavior;Cell Communication;cell type;Cells;Chromatin;Circulation;Clinical;Complex;Computing Methodologies;curative treatments;Development;Dorsal;Dysmyelopoietic Syndromes;Embryo;Embryonic Development;Endothelial Cells;Endothelium;Epigenetic Process;ETS1 gene;Extracellular Matrix;fetal;Fetal Liver;fetus cell;gene regulatory network;Genes;Genetic;genetic analysis;Genetic Transcription;Goals;Hematological Disease;Hematopoiesis;Hematopoietic;hematopoietic differentiation;Hematopoietic Neoplasms;hematopoietic stem cell fate;Hematopoietic stem cells;Hematopoietic System;hematopoietic tissue;hemogenic endothelium;Human;Image;Imaging Techniques;improved;improved outcome;in vivo;Inflammation;Inflammatory;insight;Integrin alpha Chains;Integrins;jun Oncogene;Kidney;knock-down;Lead;Life;Link;live cell imaging;loss of function;Lymphangiogenesis;Mammals;Marrow;Mediator;migration;Modeling;Molecular;mRNA Expression;multiple omics;Mus;mutant;Mutant Strains Mice;Myelogenous;Myeloid Progenitor Cells;novel;paracrine;Pathway interactions;Patient-Focused Outcomes;Patients;Population;premature;Premature aging syndrome;Procedures;programs;receptor;Reporting;Research Proposals;Residencies;Role;RUNX1 gene;Signal Transduction;single-cell RNA sequencing;Site;small molecule;Specific qualifier value;stem cell differentiation;stem cell expansion;stem cell migration;stem cell niche;stem cell therapy;Stem cell transplant;stem cells;System;Testing;Tissues;tool;Transcription Factor AP-1;transcriptome sequencing;Transplantation;Travel;Vascular Endothelial Growth Factor C;Vascular Endothelial Growth Factors;Vertebrates;young adult;Zebrafish

PROJECT_TITLE: Reprogramming of hematopoietic stem cells during contact with the perivascular niche

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Genetics;Human Genome;Microbiome

ORG_CITY: NEW YORK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Large-scale longitudinal microbiome studies offer an improved understanding of how changes in the microbiome are related to disease development and treatment efficacy, yet the dearth of available robust statistical tools has held back their potential. Within the context of several important longitudinal microbiome profiling studies, this proposal aims to develop statistical and computational approaches for enabling a more robust and sophisticated understanding of how microbes interact with exposures or outcomes over time. This information represents an imperative point of investigation both for possibly improving etiology and for possible development of microbiota-based therapies.

PI_NAMEs: LING, WODAN  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Acceleration;Address;Area;Back;base;Biological Markers;Biological Process;Bone Marrow Transplantation;Characteristics;cohort;Complex;Confounding Factors (Epidemiology);Data;data visualization;design;Development;Diabetes Mellitus;Disease;Ensure;Etiology;Evaluation;Excision;flexibility;follow-up;graft vs host disease;Health;Heterogeneity;high dimensionality;Human Microbiome;Immunocompromised Host;improved;Individual;Infant;Infection;insight;Intervention;Investigation;Kidney;Longitudinal Studies;Measurement;Methodology;Methods;Microbe;microbiome;microbiome analysis;microbiome composition;microbiome research;microbiome sequencing;microbiota;Modeling;Multivariate Analysis;Nature;novel;Outcome;Pathway Analysis;Patients;Pattern;Pharmaceutical Preparations;Population;preservation;preventive intervention;Research Personnel;response;Role;Sampling;Shapes;Signal Transduction;Statistical Methods;Structure;Taxon;Testing;Therapeutic;Therapeutic Intervention;Time;tool;Treatment Efficacy;Visualization;Work

PROJECT_TITLE: Robust Statistical Methods for Longitudinal Microbiome Studies

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_DEPT: SURGERY

PHR: Project Narrative Cardiac arrhythmias represent a major public health burden and remain a leading cause of mortality in the United States. Our proposed studies at the cellular, organ and animal levels will provide novel in vivo data on the specific role of the B56α regulatory subunit of protein phosphatase 2A (PP2A) in the regulation of the late (arrhythmogenic) sodium current and arrhythmias. Findings from this work will provide the very first insights into the impact of a PP2A activating molecule on the cardiac action potential and arrhythmias.

PI_NAMEs: EL REFAEY, MONA  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Action Potentials;Address;Adrenergic Agents;Animals;ANK3 gene;Arrhythmia;Biochemical;calmodulin-dependent protein kinase II;Cardiac;Cessation of life;clinically relevant;Complex;Coupling;Critical Pathways;Data;design;differential expression;Disease;Electrophysiology (science);experimental study;Formulation;Foundations;Future;genetic regulatory protein;Goals;Heart;Heart Diseases;Heart failure;heart function;Holoenzymes;Hypertrophy;Image;imaging approach;In Vitro;in vivo;in vivo evaluation;in vivo Model;indium arsenide;innovation;insight;Intercalated disc;Ion Channel;Isoproterenol;Knockout Mice;Link;Mediating;member;Membrane;Modeling;Molecular;mortality;Mus;Muscle Cells;novel;novel therapeutics;Ohio;Organ;patch clamp;Pathogenicity;Pathologic;Pathway interactions;Patients;pharmacologic;Phosphoric Monoester Hydrolases;Phosphorylation;Physiological;Play;preclinical study;preservation;pressure;prevent;Protein phosphatase;protein phosphatase 2A regulatory subunit 65 kDa;Proteins;Public Health;Regulation;Regulatory Pathway;Resistance;response;risk mitigation;Role;scaffold;Set protein;Signal Transduction;Sodium;Sodium Channel;Specificity;Stroke;Structural Protein;Substrate Specificity;sudden cardiac death;targeted delivery;Testing;Therapeutic;tool;Training;United States;voltage;Work

PROJECT_TITLE: Novel Roles of Protein phosphatase 2A in Cardiac Arrhythmia

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Estrogen;Mental Health;Neurosciences;Pediatric;Violence Research

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Child abuse has profound negative impacts on children’s physical and mental health. As current understanding of its neural underpinnings is limited, effective treatment to prevent and correct these hostile behaviors is lacking. The proposed study will elucidate the neural circuits underlying the generation of positive and negative infant-directed behaviors using mice as an animal model.

PI_NAMEs: LIN, DAYU  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Adult;Adult women;Aggressive behavior;Alpha Cell;Amygdaloid structure;Anatomy;Animal Model;Animals;Automobile Driving;Behavior;Birth;Brain;Calcium;Caring;Cell Nucleus;Cells;Child;Child Abuse;Child Development;Child Health;Custom;Data;Dedications;effective therapy;ESR1 gene;experience;fatherhood;Female;Fiber;Future;gain of function;Generations;Goals;Human;Image;Impairment;individual response;Infant;Infant Care;Infanticide;Knowledge;male;Maternal Behavior;Medial;Mediating;Mental Health;Molecular;motherhood;Mus;neural;neural circuit;neuromechanism;novel;offspring;optogenetics;Pathologic;Pathway interactions;perpetrators;physical conditioning;Population;Preoptic Areas;Prevalence;prevent;pup;Research;Resources;response;Role;sex;Sex Behavior;sexual dimorphism;Site;Social Behavior;Structure of terminal stria nuclei of preoptic region;Testing;Time;tool;two-photon;Ventral Tegmental Area

PROJECT_TITLE: Investigate the Neural Circuits of Infant-Directed Behaviors

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Cancer;Genetics;Human Genome

ORG_CITY: SAN ANTONIO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Project Narrative Maintenance of genome integrity is essential for life and when impaired can lead to disease, cancer in particular. Among the DNA damage types that occur continuously, double-strand DNA breaks are particularly deleterious and present great cancer risk. Successful completion of studies in our proposal will reveal the molecular mechanisms by which a family of proteins called RAD51 paralogs perform their essential function in the repair of double-strand DNA breaks and will provide a platform for the development of novel cancer therapeutics for breast, ovarian, and other cancers.

PI_NAMEs: GREENE, ERIC C;OLSEN, SHAUN  (contact);RAWAL, YASHPAL

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Architecture;base;Binding;Binding Proteins;Biochemical;Biological;Biological Assay;Biological Process;Biophysics;Breast;cancer cell;Cancer Etiology;cancer risk;Cell Cycle Progression;Cells;Chromosome abnormality;colon cancer patients;Complex;Cryoelectron Microscopy;Development;Disease;DNA;DNA Binding;DNA biosynthesis;DNA Damage;DNA damage checkpoint;DNA Double Strand Break;DNA lesion;DNA Repair;DNA Replication Damage;DNA replication fork;Double Strand Break Repair;Ensure;Failure;Fanconi's Anemia;Fiber;Filament;Foundations;Genetic;Genome;genome integrity;Germ-Line Mutation;Goals;helicase;homologous recombination;Human;Impairment;In Vitro;inhibitor;insight;Invaded;Knowledge;Lesion;Life;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;Maps;Mediating;Mediator;member;Methodology;Molecular;multidisciplinary;mutant;Mutation;Neoplastic Cell Transformation;novel;Nucleoproteins;Ovarian;PALB2 gene;paralogous gene;particle;Pathogenicity;Pathway interactions;Play;Predisposition;Preparation;preservation;presynaptic;Process;Protein Family;Proteins;Rad51 recombinase;RAD51C gene;Regulation;repaired;replication factor A;replication stress;Reporter;Research;Resected;Resistance;Resolution;Role;single molecule;Single-Stranded DNA;Site;small molecule;spatiotemporal;Specificity;Stress;Structure;Substrate Specificity;Syndrome;Tail;Testing;Therapeutic;therapeutic target;Tumor Suppression;Tumor Suppressor Proteins;tumorigenesis;Work;XRCC2 gene;XRCC3 gene

PROJECT_TITLE: Structure and function of RAD51 paralog tumor suppressor complexes in genome maintenance

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Digestive Diseases;Genetics;Hematology;Liver Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Specialized blood vessels called venous sinusoids are the nurse cells for HSCs in the marrow, but the mechanism by which they support hematopoiesis is not known. Using zebrafish, we have reprogrammed liver sinusoids to support HSPCs, providing a new location for stem cells when infiltrative processes affect the marrow such as myelofibrosis, and have also found a lipid that regulates the interaction between sinusoids and HSCs. Our studies have an impact on how sinusoids support stem cells’ expansion and will enhance current treatments for myelofibrosis and hematological disorders that require HSC transplantation.

PI_NAMEs: ZON, LEONARD IRA (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Adopted;Adult;Affect;antagonist;antagonist G;Aorta;Behavior;Biochemistry;Biological;Biology;Blood;Blood Cells;blood treatment;Blood Vessels;Bone Marrow;Cell Maintenance;Cell Therapy;Characteristics;chemical genetics;Chemicals;Coculture Techniques;Coupled;cysteinyl leukotriene receptor;Data;Development;differential expression;Discontinuous Capillary;Disease;Embryo;Endothelial Cells;Endothelium;Enhancers;Extramedullary Hematopoiesis;fetal;Fetal Liver;Fishes;Genetic;Genetic Screening;Genetic Transcription;Hematological Disease;Hematopoiesis;Hematopoietic;hematopoietic stem cell expansion;hematopoietic stem cell niche;hematopoietic stem cell self-renewal;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Human;human induced pluripotent stem cells;improved;In Vitro;in vivo;Leukotriene D4;Life;Ligands;lipidomics;Lipids;Liver;Location;Marrow;Mediating;Methods;Mus;Myelofibrosis;Nurses;Orthologous Gene;overexpression;Pathway interactions;Patients;Positioning Attribute;Process;Production;programs;Proliferating;Publishing;receptor;Recommendation;Repression;Role;single-cell RNA sequencing;Site;small molecule;Spleen;stem cell division;stem cell expansion;stem cell homeostasis;stem cells;Stress;Text;transcription factor;transplantation therapy;Travel;Veins;Venous;Work;Zebrafish

PROJECT_TITLE: Functional characterization of the endothelial cell niche for hematopoietic stem cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-V (03)]