ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Genetics;Human Genome;Infertility;Prevention;Women's Health Research

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: The goal of this proposal is to identify genetic variants in human populations that cause infertility and related conditions, including primary ovarian insufficiency, subfertility, and recurrent pregnancy loss. A combination of computational methods, cutting edge genomic assays, and genetically-engineered mouse models will be used to identify these variants that affect both protein coding parts of genes and also regulatory elements. The results on all tested variants will be posted online as they are obtained, providing crucial information for genetic diagnosis of infertility patients for generations to come.

PI_NAMEs: SCHIMENTI, JOHN C (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: accurate diagnosis;Address;Affect;Age;age related;Alleles;Amino Acids;Aneuploidy;Benign;Biochemical;Biological Assay;candidate selection;cell type;chromosome missegregation;Code;Collection;Computational Biology;Computing Methodologies;cost;Couples;CRISPR/Cas technology;Databases;de novo mutation;Defect;detection method;Development;Diagnosis;Disease susceptibility;DNA Sequence Alteration;DNA sequencing;Embryo;Embryo Loss;Embryonic Development;Enhancers;Exhibits;exome sequencing;experience;Fertility;Fertilization;Frequencies;Funding;Gametogenesis;Gene Modified;Generations;Genes;Genetic;Genetic Crossing Over;genetic disorder diagnosis;genetic pedigree;Genetic Polymorphism;Genetic Recombination;Genetic Transcription;genetic variant;Genetically Engineered Mouse;Genome;genome editing;genome sequencing;genome wide association study;Genomic medicine;Genomics;Genotype-Tissue Expression Project;Germ Cells;Goals;Health;Hereditary Disease;Heterogeneity;Human;human model;idiopathic infertility;improved;in vitro Assay;in vivo;Infertility;innovation;Link;Litter Size;Maintenance;Meiosis;Methodology;Methods;Minor;Mismatch Repair;MLH1 gene;Modeling;mouse model;multidisciplinary;Mus;Mutant Strains Mice;Mutation;Nature;novel;Nucleic Acid Regulatory Sequences;offspring;Ovarian;ovarian reserve;Patients;personalized genomics;Persons;Phenotype;Population;Pregnancy loss;primary ovarian insufficiency;Privatization;Probability;proband;Process;Productivity;promoter;protein function;protein protein interaction;Proteins;Proteomics;Recurrence;Regulatory Element;Reporter Genes;Reproduction;reproductive;Resources;RNA;segregation;sex;Single Nucleotide Polymorphism;subfertility;Technology;Testing;Time;Transcriptional Regulation;Transgenic Mice;Transgenic Organisms;Untranslated RNA;Validation;Variant;vector;women's reproductive health

PROJECT_TITLE: Identification and Functional Validation of Human Infertility Alleles

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: ROCHESTER

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PI_NAMEs: HAEFNER, RALF MANFRED (contact)

PROJECT_TERMS: Agreement;Animals;Area;area MT;Auditory;Bayesian Modeling;Behavior;Behavioral;Belief;Brain;causal model;Complex;Control Animal;Data;Depth Perception;Elements;Event;experience;Foundations;generative models;Goals;Human;Link;Modeling;Monkeys;Motion;Motion Perception;neural;neural circuit;neural correlate;neural patterning;Neurons;novel;object motion;Pattern;Perception;Population;Process;Psychophysics;receptive field;response;Retina;retinal imaging;Reverse engineering;Running;Sensory;sensory input;Signal Transduction;Testing;Texture;Time;Uncertainty;Visual;Work

PROJECT_TITLE: Project A:  Theoretical framework for studying causal inference in trial-based and continuous tasks


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: SAN ANTONIO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE  The need has never been greater for highly trained young scientists dedicated to a career in substance use disorder (SUD) research. Now in its 9th year at the University of Texas Health Science Center at San Antonio, this Program is addressing that need by providing SUD research training and career development support for talented young investigators, including many from populations that are underrepresented in biomedical science. The Program, managed by a Director, Associate Director, and Coordinator, has evolved and improved with the guidance of External and Internal Advisory Committees, resulting in a flourishing Program that has all positions filled, and trainees who have been productive in research and unanimously successful in securing independent positions, including many in academia.

PI_NAMEs: FRANCE, CHARLES P (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TITLE: Postdoctoral Training in Drug Abuse Research: Behavior & Neurobiology


PI_NAMEs: DEANGELIS, GREGORY C (contact)

PROJECT_TERMS: Affect;Animals;Area;area MT;Attention;Back;Behavior;Behavioral;Belief;Brain;Data;design;Event;experimental study;extrastriate visual cortex;Feedback;Goals;Impairment;Judgment;Light;Link;Macaca;Mediating;Modeling;Monkeys;Motion;Muscimol;neural;neural circuit;neural correlate;Neural Pathways;object motion;optic flow;optogenetics;Parietal;Pathway interactions;Pattern;Physics;Population;predictive modeling;Process;Reporting;Retina;retinotopic;Role;Sensory;sensory cortex;Signal Transduction;Structure;Testing;Time;Training;Update;Visual Cortex;visual processing;Work

PROJECT_TITLE: Project B:  Neural basis of causal inference and sensory updating in trial-based tasks in monkeys


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: BOSTON

ORG_NAME: SCHEPENS EYE RESEARCH INSTITUTE

ORG_STATE: MA

PHR: Notorious for being effector cells in allergic disease, there is a growing appreciation for the diverse immune functions of mast cells in a wide range of non-allergic inflammatory disorders. Based on our publications and robust preliminary data, we propose to delineate mechanisms by which mast cells promote the tissue- damaging function of neutrophils and delay inflammatory vessel regression in non-allergic ocular disorders, anticipating the understanding of these mechanisms will yield therapeutic targets for ocular and other tissue injuries and inflammation.

PI_NAMEs: CHAUHAN, SUNIL K (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Acceleration;Allergic Disease;angiogenesis;ANGPT1 gene;Antibodies;Antibody Therapy;ANXA5 gene;arm;Attention;Attenuated;Biological Assay;Blood Vessels;Bone Marrow;Brightfield Microscopy;Cell Communication;Cell Physiology;Cell Survival;Cells;chemokine;Clinical;Coculture Techniques;Computer software;Confocal Microscopy;Cornea;Corneal Injury;Corneal Neovascularization;CRISPR/Cas technology;Cromoglicic Acid;CSF3 gene;CXCL2 gene;cytokine;Data;design;differential expression;Disease;Effector Cell;Endothelial Cells;Enzymes;Epithelial Cells;experimental study;Eye;Eye diseases;first responder;Fluorescein;Functional disorder;Goals;granulocyte;Granulocyte-Macrophage Colony-Stimulating Factor;Growth;Histologic;IgE;Image;Immune;immune function;Immunofluorescence Immunologic;Immunologics;improved outcome;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injury;Interleukin-1 beta;Interleukins;Investigation;ITGAM gene;Kinetics;Laboratories;Ligands;lymphatic vessel;mast cell;Mast Cell Stabilizer;Measures;Mediating;Modeling;mouse model;Mus;neovascularization;neutralizing antibody;neutrophil;Neutrophil Infiltration;novel;novel therapeutic intervention;novel therapeutics;Ocular Pathology;ocular surface;Pathogenesis;Pathologic;Pathology;PECAM1 gene;Plug-in;Propidium Diiodide;Proteins;Publications;receptor;reconstitution;Reporting;Research;Series;Site;slit lamp imaging;Stains;Standardization;System;Testing;therapeutic target;TIE-2 Receptor;tissue injury;tissue repair;Tissues;Topical application;Transcript;Treatment Efficacy;Tube;Vascular Endothelial Cell;Vascular Endothelial Growth Factors;vessel regression;Work

PROJECT_TITLE: Contribution of Mast Cells in Non-Allergic Ocular Inflammation

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

PI_NAMEs: ANGELAKI, DORA  (contact)

PROJECT_TERMS: Animal Behavior;Animals;Area;Behavior;Behavior monitoring;Behavioral;Behavioral Model;Belief;Brain;Brain region;Chemicals;computer framework;Contralateral;Data;Decision Making;Dimensions;Dorsal;Electrodes;Electrophysiology (science);Event;experimental study;extrastriate visual cortex;Feedback;Fireflies;Goals;Joystick;Laboratories;Link;Liquid substance;Location;Macaca;Maps;Medial;medial temporal lobe;Memory;Modeling;Monkeys;Motion;Mus;Muscimol;neural;neural patterning;Neurons;neurophysiology;neurotransmission;novel;object motion;optic flow;optogenetics;Parietal;Pattern;Perception;Population;Process;Reporting;Retina;Rewards;Sampling;Sensory;sensory input;Signal Transduction;Specific qualifier value;Speed;Structure;Testing;theories;Time;tool;Trackball Device Component;Training;Update;virtual reality;Visual Perception

PROJECT_TITLE: Project C:  Neural basis of causal inference in continuous navigation


ADMINISTERING_IC: DK

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: COLLEGE PARK

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Copper is an essential mineral for sustaining life, yet it is toxic when misplaced or accumulated in excess. The proper acquisition, distribution, and utilization of copper and the regulation of copper metabolism are vital to normal human health. This project aims to gain new mechanistic insights into how copper supports adipose function and may provide a basis for understanding how copper deficiency is linked to other metabolic pathologies, including obesity and diabetes.

PI_NAMEs: KIM, BYUNG-EUN  (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Acute;adipocyte differentiation;Adipocytes;Adipose tissue;Adrenergic Agents;Adrenergic Receptor;Affinity;Biochemical;Biogenesis;Biological;Biology;biophysical techniques;Brown Fat;Candidate Disease Gene;Cardiomyopathies;Cell Membrane Permeability;Cells;Cessation of life;cofactor;cold stress;Connective Tissue;Copper;Cyclic AMP;Defect;Diabetes Mellitus;Electron Transport;empowerment;Endosomes;Energy Metabolism;Etiology;Exhibits;Exposure to;Fluorescence Microscopy;Funding;Generations;Genetic;Goals;Health;Hepatolenticular Degeneration;Homeostasis;Hormones;Hour;Human;human disease;hypocupremia;Impairment;improved;in vivo;Injections;insight;Ionophores;Iron;Knockout Mice;Life;Link;lipid metabolism;Lipids;Lipolysis;Location;Mediating;Mediator;Menkes Kinky Hair Syndrome;Metabolic;Metabolism;Metals;Methods;Minerals;Mitochondria;Modeling;Molecular;Mus;Mutant Strains Mice;Mutation;natural hypothermia;Nature;Nerve Degeneration;Non-Insulin-Dependent Diabetes Mellitus;Norepinephrine;novel;novel therapeutic intervention;Obesity;Pathogenicity;Pathology;Pathway interactions;Patients;pharmacologic;Physiologic Thermoregulation;Predisposition;Prevalence;Protein Family;recruit;Regulation;Resistance;response;RNA Interference;Roentgen Rays;Role;sensor;Signal Pathway;Signal Transduction;Site;small molecule;Stimulation of Cell Proliferation;subcutaneous;Sympathetic Nervous System;Testing;Thermogenesis;Tissues;Trace Elements;trafficking;Transcript;transcriptome;Transition Elements;uncoupling protein 1;uptake;Wild Type Mouse

PROJECT_TITLE: The Role of Copper and CTR1 in the Regulation of Adipose Function

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Narrative - Metabolic determinants of Mtb virulence, vulnerability and variation Tuberculosis (TB) is caused by the bacterium Mycobacterium tuberculosis (Mtb), whose unique outer envelope forms a physical barrier with the infected patient. To develop more effective antibiotics, we will identify molecules in the Mtb envelope that promote antibiotic entry and molecules that reduce Mtb survival. Further, to limit the worldwide spread of TB, we will develop rapid diagnostic tests based chemicals detected in the blood, urine and exhaled breath of patients.

PI_NAMEs: MOODY, DAVID BRANCH (contact);RHEE, KYU Y

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: active control;Advanced Development;Aerosols;Anabolism;Antibiotics;Antimycobacterial Agents;arabinofuranose;Bacteria;Biological;Biological Assay;Biological Markers;Biology;Blood;cell envelope;Characteristics;chemical property;Chemicals;Clinical;clinically relevant;comparative;Complex;CRISPR interference;Detection;Development;Diagnostic;diagnostic strategy;Diagnostic tests;Disease;DNA-Directed RNA Polymerase;drug action;Drug Regulations;Drug resistance in tuberculosis;drug testing;drug-sensitive;Elements;Ethambutol;Exhalation;Foundations;gene synthesis;Genes;Genetic;genome wide association study;genome-wide;Genomics;Genus Mycobacterium;Growth;Human;Hydrophobicity;Immune response;in vivo Model;interdisciplinary approach;Knowledge;Lecithin;Link;lipid biosynthesis;lipidomics;Lipids;Maps;Mass Spectrum Analysis;Mediating;Membrane;Membrane Lipids;Metabolic;metabolic profile;metabolomics;Modeling;mouse model;Mus;mycobacterial;Mycobacterium tuberculosis;mycolate;Organism;overexpression;pandemic disease;pathogen;patient population;Patients;Penetration;Peptidoglycan;Performance;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Physiology;Plasma;point-of-care diagnostics;Polymers;Polysaccharides;Prevalence;Rapid diagnostics;Research;Resistance;response;response biomarker;Rifampin;Role;Sampling;Scientist;Serum;Site;South Africa;Species Specificity;Sphingomyelins;Sputum;Structure;Surface;Synthesis Chemistry;System;Technology;Therapeutic;Time;tool;treatment response;Tuberculosis;urinary;Urine;Variant;Virulence;Virulent;Whole Organism


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Contraception/Reproduction;Infant Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: QUEENS

ORG_NAME: ST. JOHN'S UNIVERSITY

PHR: NARRATIVE Preterm birth occurs in more than 10% of deliveries in most countries, is the leading cause of neonatal mortality and disproportionally affects underserved populations. We have discovered that the readily accessible drug solvent, N,N-dimethylacetamide (DMA), prevents preterm birth in a preclinical model. Here we test a novel vaginal DMA self-nanoemulsifying drug delivery system for its ability to prevent preterm birth by inhibiting cervix ripening while avoiding off target effects.

PI_NAMEs: REZNIK, SANDRA EVE (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: 37 weeks gestation;Acute;Address;Affect;Atopobium vaginae;Attenuated;biomedical scientist;Birth;Caproates;care costs;Cells;Cervix Uteri;Clinical;Clinical Trials;Clinics and Hospitals;Cognitive;Collagen;collagenase;Communities;Connective Tissue;Country;Creativeness;crosslink;cytokine;Cytoplasm;Data;design;Dose;Drug Delivery Systems;drug development;Drug Formulations;Excipients;experience;extracellular;Extracellular Matrix;Family;FDA approved;Fetus;Formulation;Funding;Genetic Transcription;Goals;Health Personnel;Health Professional;Human;Hydroxyprogesterone;I Kappa B-Alpha;Immune;Impaired cognition;Inflammation;Inflammatory;Inflammatory Response;intraperitoneal;Investigation;Knowledge;Laboratories;Leukocytes;Life;life span;Macrophage;Matrix Metalloproteinases;Mediating;Microscopic;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;multicatalytic endopeptidase complex;multidisciplinary;Mus;N-Dimethylacetamide N;nanoformulation;Neonatal Mortality;neurobehavioral test;NF-kappa B;nonhuman primate;novel;novel strategies;Nuclear Translocation;p65;Pathologist;Patients;Perinatal;Perinatal mortality demographics;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacotherapy;Phenotype;Placebos;Placenta;Population;Population Heterogeneity;pre-clinical;Pre-Clinical Model;premature;Premature Birth;Preparation;prevent;Prevention;Process;Public Health;pup;research and development;Research Personnel;Resources;Risk;risk minimization;Safety;Signaling Molecule;skills;small molecule;Societies;Solvents;Spontaneous abortion;Structure;Students;systemic toxicity;Talents;Teratogenic effects;Teratogens;Testing;Tissues;Toxic effect;Training;transcription factor;Translational Research;trophoblast;ubiquitin ligase;Underserved Population;United States Food and Drug Administration;Uterus;Vagina;Work;World Health Organization

PROJECT_TITLE: N,N-Dimethylacetamide Vaginal Self-nanoemulsifying Drug Delivery System for the Prevention or Preterm Birth


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

PI_NAMEs: MOODY, DAVID BRANCH (contact)

PROJECT_TERMS: Accountability;Administrator;Affinity;Annual Reports;Bioinformatics;career development;Communication;Computer software;Data;data management;Data Set;data submission;Development;Development Plans;Expenditure;experience;Gene Modified;Genetic;Genomics;Goals;Group Meetings;Hospitals;Individual;interdisciplinary collaboration;Internships;lipidomics;Medicine;meetings;member;Metabolic;metabolomics;Monitor;multidisciplinary;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;Principal Investigator;Process;programs;Publications;Reporting;Research;Research Personnel;Resource Sharing;Sampling;Shipping;Site;System;Teacher Professional Development;Techniques;timeline;Training;Travel;Tuberculosis;United States National Institutes of Health;Variant;Virulence;Woman

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

PROJECT_TERMS: aqueous;archive data;Bacteria;Bacteriology;Biochemical;Bioinformatics;bioinformatics resource;Biological;Biological Assay;Catalogs;Chemical Structure;Chemicals;Chromosome Mapping;Clinical;Communities;community setting;comparative;computing resources;CRISPR interference;Data Set;Databases;Detection;detection platform;Development;Diagnostic;diagnostic development;Diagnostics Research;Disease;drug-like compound;Escherichia coli;Eukaryotic Cell;gene function;Genes;Genetic;Genomics;Goals;Hour;Housekeeping;Human;Immune response;Infectious Diseases Research;Investigation;Laboratories;Left;Link;lipidome;lipidomics;Lipids;Maps;Mass Spectrum Analysis;Measurement;Measures;member;Membrane;Membrane Lipids;Metabolic;Metabolism;metabolome;metabolomics;Methods;Modeling;Modernization;mycobacterial;Mycobacterium tuberculosis;mycolate;Names;operation;Organism;pathogen;Patients;Penetration;Permeability;Pharmaceutical Preparations;Physiology;Prevalence;rapid technique;Research;Research Personnel;Sampling;Series;South Africa;South African;South America;Structure;System;Systems Biology;Time;tool;transmission process;Tuberculosis;Variant;Virulence;Whole Organism

PROJECT_TITLE: Profiling and Mapping Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Natural Products;Rare Diseases;Tuberculosis

PI_NAMEs: MINNAARD, ADRIAAN  (contact)

PROJECT_TITLE: Chemical Synthesis Core C


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Infertility

ORG_CITY: WOODS HOLE

ORG_NAME: MARINE BIOLOGICAL LABORATORY

PHR: Project Narrative Continuous education and training of scientists in reproductive biology research is necessary to ensure discoveries that will fuel reproductive success and health in humans and animals. The development of new therapeutics and strategies, and the training of the next generation of scientists who will lead these advances, are essential to ensure our fertility and that of those species with whom we share the planet. The Frontiers in Reproduction Course at the Marine Biological Laboratory in Woods Hole, MA promotes discoveries in the field by bringing together scientific experts and students in an advanced, hands-on training course that teaches fundamentals and emerging concepts in reproductive biology, describes applications in the clinic, examines ethical issues and builds a strong community of highly skilled reproductive biology scientists.

PI_NAMEs: FISSORE, RAFAEL ANTONIO;HYMAN, LINDA E (contact)

PROJECT_TERMS: Amphibia;Animal Model;Animals;Assisted Reproductive Technology;Award;Basic Science;Behavior;Biological;Biomedical Research;Biotechnology;career;Clinic;clinical application;Clinical Research;Collaborations;Communication;Communities;course introduction;Data;Data Analyses;Dedications;design;Development;Drosophila genus;Educational Curriculum;Educational process of instructing;Embryo;Embryonic Development;Ensure;Environment;Equipment;Ethical Issues;Ethics;Faculty;female reproductive tract;Fertility;fertility preservation;Fertilization;Fostering;frontier;fundamental research;Gametogenesis;Germ Cells;Goals;graduate student;Human;Immersion;implantation;improved;Individual;Infertility;innovation;Institution;Instruction;Knowledge;Laboratories;laboratory curriculum;laboratory experience;laboratory experiment;Lead;lectures;Legal;Livestock;male;marine;Mentors;Mentorship;Methods;Modeling;Molecular;next generation;novel therapeutics;Oral;Organ;organ growth;Participant;peer networks;Physicians;Placentation;Planets;Postdoctoral Fellow;Procedures;Production;programs;Regulation;Reproduction;reproductive;Reproductive Biology;Reproductive Endocrinology;Reproductive Health;reproductive neuroendocrinology;Reproductive Sciences;reproductive success;Request for Applications;Research;Research Personnel;research study;Research Technics;Research Training;Rodent;Scientist;Series;Sex Differentiation;skills;Societies;student training;Students;success;symposium;Techniques;Technology;theories;Training;Training and Education;Translational Research;United States National Institutes of Health

PROJECT_TITLE: Frontiers in Reproduction (FIR) Training Course

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Opioids;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Substance Misuse

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative: This project will employ iPSC-derived microglial cells and cerebral organoids to understand how HIV interacts with cells in the brain, in order to replicate and dissect the causes of inflammation that results in HIV-associated neurocognitive disorders (HAND). Microglia express an important attachment factor, Siglec- 1, that is known to enhance HIV particle retention by myeloid cells and to enhance HIV transmission events. Studies in this project will help define how microglia harbor, retain, and transmit virus, and will determine how fentanyl alters HIV-associated gene expression and replication in the CNS organoid model.

PI_NAMEs: SPEARMAN, PAUL W. (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: 3-Dimensional;acute infection;AIDS dementia;Animal Model;antiretroviral therapy;Astrocytes;Biological Models;Brain;CD4 Positive T Lymphocytes;Cell Communication;Cell Line;Cell membrane;cell type;Cells;Central Nervous System;Central Nervous System Infections;Cerebrum;Clustered Regularly Interspaced Short Palindromic Repeats;cytokine;Development;differential expression;Disease;DNA;Event;experimental study;Exposure to;Fentanyl;fentanyl exposure;Fluorescence Microscopy;Gangliosides;Gene Expression;Gene Expression Profiling;Goals;HIV;HIV-1;HIV-associated neurocognitive disorder;In Vitro;Individual;induced pluripotent stem cell;Infection;Inflammation;insight;Interferons;Knock-out;knockout gene;Laboratories;Lipid Bilayers;live cell microscopy;Macrophage;Measurement;Measures;Mediating;Microglia;Modeling;Molecular;monocyte;Morbidity - disease rate;Morphine;Myeloid Cells;Neurocognitive Deficit;Neuroglia;Neurons;neurotoxic;new therapeutic target;novel;Opiate Addiction;Opioid;Organoids;particle;Pathogenesis;Persons;Prevalence;Production;Reporter;Reporting;Role;sialic acid binding Ig-like lectin;sialoadhesin;Signal Transduction;System;T-Lymphocyte;Tissues;transcriptomic profiling;transmission process;two-dimensional;United States;uptake;Viral;Viral reservoir;viral transmission;Virion;Virus

PROJECT_TITLE: Role of Siglec-1 in HIV Interactions with Microglia and Astrocytes


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

ORG_CITY: MINNEAPOLIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Currently, we are in a period of history where the number of individuals over the age of 65 is doubling, leading to an epidemic of chronic multi-morbidities of old age, and creating an urgent need to discover underlying mechanisms of aging biology that promote disease. “Functional Multi-omics of Aging” is a training program in basic and translational aging research for pre- and post-doctoral trainees addressing this need. The program's success over the last 14 years is documented by outstanding publications and successful careers in biomedical research of former trainees.

PI_NAMEs: ARRIAGA, EDGAR A;LOWE, DAWN A (contact);NIEDERNHOFER, LAURA JANE

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Aging;multiple omics

PROJECT_TITLE: Functional Multi-omics of Aging


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

PI_NAMEs: ROCK, JEREMY MICHAEL (contact)

PROJECT_TERMS: Achievement;Age;Antibiotics;Antimycobacterial Agents;Bacterial Genes;bacterial genetics;Base Pairing;Biochemical;Biological;Clinical Drug Development;CRISPR interference;design;design and construction;Development;Drug resistance;Drug resistant Mycobacteria Tuberculosis;Drug Targeting;Essential Genes;experimental study;Gene Silencing;Gene Targeting;Generations;Genes;Genetic;genetic manipulation;Genetic Transcription;Genome;genome-wide;Growth;Guide RNA;Human;Immune response;Immune system;in vivo;Individual;interest;knock-down;knockout gene;Laboratories;Length;Libraries;lipidomics;Lipids;M. tuberculosis genome;Mediator;Metabolic;Methods;Microbiology;Multi-Drug Resistance;mutant;Mutation;mycobacterial;Mycobacterium tuberculosis;Nature;novel;novel strategies;nuclease;Nucleotides;Open Reading Frames;Organism;Patients;Pharmaceutical Preparations;Phenotype;Production;Proteins;Research;response;Rifampicin resistance;RNA;Role;screening;Signal Transduction Pathway;small molecule;stem;Technology;Variant;Virulence;Virulence Factors;Work

PROJECT_TITLE: Bacterial Genetics Core D


NIH_SPENDING_CATS: Diabetes;Kidney Disease

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: NARRATIVE More than 400 million people suffer from diabetes in the world and one third of them may eventually develop diabetic kidney disease. However, currently we do not have any effective treatment for this disease. The proposed studies may help us to develop novel class of drugs to treat this disease and therefore should be highly significant.

PI_NAMEs: HE, JOHN CIJIANG (contact);LIU, RUIJIE

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: Actins;Adhesions;Affect;Affinity;Albuminuria;arctigenin;Attenuated;Binding;Binding Proteins;Biological Assay;Biology;Cell Adhesion;Cells;China;Chinese Herbs;Chronic Kidney Failure;Cytoskeleton;Data;db/db mouse;Development;Diabetes Mellitus;diabetic;Diabetic mouse;Diabetic Nephropathy;differential expression;Disease;Disease Progression;Docking;drebrins;Drug Combinations;Drug Targeting;effective therapy;F-Actin;Genes;Glucose;Herbal Medicine;Herbal remedies;Human;improved;In Vitro;Inflammation;Inflammatory;Injury;Injury to Kidney;insight;Insulin-Dependent Diabetes Mellitus;Kidney;kidney cell;Kidney Diseases;knock-down;Knock-out;Knockout Mice;Mass Spectrum Analysis;Mediating;Methods;migration;Modeling;mouse model;Mus;mutant;Mutation;NF-kappa B;Non-Insulin-Dependent Diabetes Mellitus;novel;novel drug class;novel therapeutics;Outcome;p65;Paper;Pathogenesis;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;phenome;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphorylation Site;Play;podocyte;protective effect;protein activation;Protein Dephosphorylation;Protein Isoforms;Protein phosphatase;Proteins;Proteinuria;Regulation;Role;scaffold;Scanning;Signal Transduction;Site;Streptozocin;Surface Plasmon Resonance;Techniques;Testing;transcriptome sequencing;transcriptomics;Transgenic Organisms;type I and type II diabetes;Variant;Western Blotting

PROJECT_TITLE: PP2A as a drug target for diabetic kidney disease

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: HG

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Genomics technology and the computer have revolutionized biomedical science. To enable the success of future biomedical researchers, a paradigm shift in graduate education is required, one in which biology and the more quantitative sciences, especially computation, are given equal weight. The NHGRI training program at Princeton has been one of the pioneer programs fulfilling this role.

PI_NAMEs: AKEY, JOSHUA MICHAEL;STOREY, JOHN D (contact)

PROGRAM_OFFICER_NAME: XIRASAGAR, SANDHYA

PROJECT_TERMS: Computational Biology;programs

PROJECT_TITLE: Quantitative and Computational Biology Graduate Program


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Tuberculosis

PI_NAMEs: SMITH, CLARE MARGARET (contact)

PROJECT_TERMS: Address;Aerosols;Animal Model;animal model development;Animals;Bacterial Genes;bacterial genetics;Bar Codes;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collaborations;CRISPR interference;Data;Diagnostic;Diagnostic tests;Disease;Disease Outcome;Disease Progression;Dose;Encapsulated;experimental study;Genes;Genetic;genetic resource;Genetic Variation;genome-wide;Goals;Growth;Human;human disease;in vivo;in vivo evaluation;Inbred Mouse;Inbred Strain;Individual;Infection;Inflammation;Integration Host Factors;interest;knock-down;Laboratories;Libraries;Link;lipidomics;Lipids;Lung;Lung infections;Mammalian Genetics;Measures;Metabolic;Modeling;mouse model;Mouse Strains;Mus;mutant;Mutation;mycobacterial;Mycobacterium tuberculosis;Natural regeneration;Outcome;pathogen;Pathogenesis;Pathology;Patients;Phenotype;Predisposition;pressure;Process;programs;Recombinants;Reproducibility;Resistance;Resources;response;Role;Serum;stem;System;Testing;trait;transposon sequencing;Tuberculosis;Universities;Variant;Virulence

PROJECT_TITLE: Animal Model Core E


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: The first year after military service separation is a critical time to reach reintegrating Veterans, as the suicide rate among Veterans is highest during this first year. One of the most common challenges reintegrating Veterans face involves redefining who they are and where they are going in life as civilians, called role functioning, which impacts their functioning in adult life roles. Deficits in role functioning are also strongly associated with suicide risk. However, no evidence-based interventions address role functioning to reduce suicide risk. The proposed study will examine the acceptability of virtually-delivered health coaching, an understudied health behavior change modality, among reintegrating Veterans during their first year of service separation. We will also gather data to inform study design, including measure selection, for a subsequent fully powered efficacy trial of health coaching. This study will also inform future implementation needs for using health coaching as a population-based rehabilitation approach to suicide prevention.

PI_NAMEs: DENNESON, LAUREN M (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Adverse event;Articulation;Calibration;care providers;Caring;Client;Client satisfaction;Clinic;Clinical;Confidence Intervals;confirmatory trial;cost;Data;design;effectiveness evaluation;efficacy evaluation;efficacy trial;Employment;Enrollment;Evaluation;Evidence based intervention;experience;Face;Feasibility Studies;Feedback;Feeling suicidal;follow up assessment;follow-up;functional improvement;functional status;Future;future implementation;Goals;group intervention;Health;Health behavior change;high risk;implementation facilitators;implementation strategy;improved;innovation;Intervention;intervention participants;Interview;Investments;Joints;Knowledge;Life;Measures;Mediator;Methodology;Methods;military service;Mission;Modality;Outcome;outreach;Pamphlets;Participant;participant interview;Patient Self-Report;Persons;Pilot Projects;pilot test;pilot trial;Population;population based;post intervention;preference;Procedures;Process;Questionnaires;Randomized;reducing suicide;rehabilitation research;Rehabilitation therapy;Reporting;Research;research and development;Research Design;Resources;response;Role;Sample Size;Sampling;satisfaction;Self Direction;Self Perception;Services;suicidal risk;Suicide attempt;Suicide prevention;suicide rate;surveillance data;Telephone;Time;treatment as usual;treatment effect;usual care arm;Variant;Veterans;Veterans Health Administration;Violence;virtual delivery

PROJECT_TITLE: A pilot trial of health coaching to improve functioning and reduce suicide risk among reintegrating Veterans

STUDY_SECTION_NAME: Behavioral Health & Social Reintegration[RRD4]


FUNDING_MECHANISM: OTHERS

ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

ORG_STATE: CA

PHR: Veterans with mental illness face challenges with community reintegration, including achieving vocational success, attaining their educational goals and going back to school, and maintaining a high quality of life. VA mental health Residential Rehabilitation Treatment Programs and Psychosocial Rehabilitation and Recovery Centers are designed to help Veterans overcome these barriers, but cognitive impairment often seen in Veterans with mental illness limits gains from these settings. Cognitive remediation interventions can be helpful, but they are either “one-size fits all,” and thus may not be useful for all Veterans with mental illness, or are too narrow in scope, focusing on specific mental illnesses, limiting generalizability. This project will test whether an objective biomarker can better match the “right” Veteran to the “right” cognitive remediation treatment regardless of their specific mental health diagnosis. Information gained from this study will help establish a precision-medicine approach towards cognitive rehabilitation for Veterans with mental illness.

PI_NAMEs: JOSHI, YASH B (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Affect;Age;Anti-Cholinergics;Attenuated;Back;Biological Markers;career;Caring;Clinical;Clinical Trials Design;Cognition;Cognitive;cognitive benefits;cognitive function;cognitive rehabilitation;Cognitive remediation;Communities;community reintegration;Data;Demographic Factors;design;Diagnosis;Diagnostic;Dimensions;disability;disabled;Education;Effectiveness;Electroencephalography;Event-Related Potentials;Exercise;experience;Face;functional outcomes;Future;Goals;Health Resources;Healthcare Systems;Hour;Impaired cognition;improved;improved outcome;Individual;information processing;innovation;interest;Intervention;Interview;Link;Measures;Mediating;Medical center;Mental disorders;Mental Health;Mental Health Services;Methodology;military veteran;Motivation;neuropsychiatry;Patients;Performance;Pharmaceutical Preparations;Population;precision medicine;programs;psychiatric comorbidity;psychosocial;Psychosocial Assessment and Care;psychosocial outcome;psychosocial rehabilitation;Quality of life;Recovery;recruit;Rehabilitation therapy;remediation;Reporting;Schools;Scientist;Services;Site;skills;social;success;symptom management;Testing;Therapeutic;Training;training opportunity;Training Programs;treatment program;Veterans;Vocation;Work

PROJECT_TITLE: Optimizing Cognitive Remediation in VA Mental Health Rehabilitation Settings

STUDY_SECTION_NAME: Career Development Program - Panel II[RRD9]


ORG_CITY: BEDFORD

ORG_NAME: EDITH NOURSE  ROGERS MEMORIAL VETERANS HOSPITAL

PHR: Meaningful employment is consistently associated with the health and well-being of individuals living with psychiatric disorders, yet few Veterans reap this benefit due to high levels of un- and underemployment. Thus, there is a critical need for interventions to help Veterans with psychiatric disorders find and maintain meaningful employment. The Veterans Health Administration (VHA) is committed to improving employment outcomes among Veterans and is particularly interested in meaningful employment as important for suicide prevention. This research proposal seeks to enhance vocational rehabilitation services by developing and testing an evidence-informed career counseling and development protocol. This work will fill a substantial gap in VHA vocational services as empirically informed career counseling and development interventions for Veterans living with psychiatric disorders does not currently exist.

PI_NAMEs: STEVENSON, BRIAN  (contact)

PROJECT_TERMS: acceptability and feasibility;Applications Grants;Attenuated;Award;Behavior;Belief;career;career development;Chronic disability;Compensation;Complex;Counseling;Data;design;Development;Dissemination and Implementation;efficacy testing;efficacy trial;Employment;Evaluation;evidence base;Evidence based practice;experience;functional improvement;functional loss;Future;Goals;Health;high risk;improved;Individual;innovation;interest;Intervention;Intrinsic factor;Manuals;Mental disorders;Mentors;Monitor;multidisciplinary;Needs Assessment;Occupations;Outcome;Personal Satisfaction;Persons;pilot test;Population;programs;protocol development;Provider;Psychological Factors;Randomized, Controlled Trials;rehabilitation service;Research;Research Personnel;Research Proposals;Resources;Secure;Self Efficacy;Services;Strategic Planning;Suicide prevention;System;Testing;therapy development;Time;tool;Training;treatment as usual;Treatment Efficacy;trial comparing;Underemployment;Unemployment;Veterans;Veterans Health Administration;Vocation;Vocational Guidance;Vocational rehabilitation;Work

PROJECT_TITLE: Improving Vocational Outcomes of Veterans with Psychiatric Disorders: Career Counseling & Development


ORG_CITY: BRONX

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

PHR: Suicide is a major problem in the Veteran population with 20 Veterans dying by suicide daily. While psychotherapeutic treatments are available for Veterans during the period of acute suicide risk, there are no treatments available specifically designed to promote the recovery of Veterans following a suicidal episode. This is a critical gap in Veteran mental health care and in comprehensive suicide treatment. This study aims to develop and pilot test a recovery oriented intervention for Veterans who have been acutely suicidal in the past year but are no longer at high risk. The treatment aim is to promote the Veteran’s development of a positive self-narrative extending into a vivid and desired future and is designed to closely map onto primary recovery processes such as increased life meaning, hopefulness, empowerment and improved personal identity. This project will result in Veteran specific treatment materials and information about the acceptability and feasibility of this intervention needed for a future large scale intervention trial.

PI_NAMEs: SOKOL, YOSEF  (contact)

PROJECT_TERMS: acceptability and feasibility;active control;Acute;Address;Aftercare;Age;Area;arm;career;Caring;Chronic;Clinical;Cognitive Therapy;Data;Dedications;Depressed mood;design;Development;disability;empowerment;evidence base;Exhibits;experience;Feedback;Feeling hopeless;Feeling suicidal;follow-up;Funding;Future;Goals;Group Therapy;Health;Health education;high risk;Hotlines;Hour;implementation science;improved;Individual;Intervention;Intervention Trial;Length;Life;Literature;male;Manuals;Maps;Mechanics;Mental Depression;Mental Health;Mental Health Services;Mentors;military veteran;Monitor;Needs Assessment;Outcome;Outcome Measure;Participant;Persons;Phase;Pilot Projects;pilot test;Population;primary outcome;Process;Protocols documentation;psychoeducation;Psychotherapy;Quality of life;readmission rates;Recording of previous events;Recovery;Recovery of Function;recruit;reducing suicide;Rehabilitation therapy;Reporting;Research;Research Personnel;resilience;response;retention rate;Risk;Risk Factors;Role;Running;Safety;Sampling;satisfaction;secondary outcome;Self Direction;Self Efficacy;social attachment;Social Network;social relationships;Specific qualifier value;suicidal;suicidal individual;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Symptoms;Testing;therapy design;therapy development;Time;Training;treatment adherence;treatment arm;treatment duration;Update;Veterans

PROJECT_TITLE: Development of a Recovery Oriented Treatment for Post Acute Suicidal Episode (PASE) Veterans

STUDY_SECTION_NAME: Career Development Program - Panel I[RRD8]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Genetics;Lung;Lung Cancer;Rare Diseases

ORG_CITY: NEW ORLEANS

ORG_DEPT: BIOLOGY

ORG_NAME: XAVIER UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative: Role of the transcriptional corepressor TLE1 in the lung adenocarcinoma aggressiveness and progression  Human lung adenocarcinoma (LUAD) is the most commonly diagnosed histological subtype of lung cancer with a mere 15% five year survival rate. Our laboratory is investigating the utility of targeting the pro- oncogenic and molecular function of the transducin-like enhancer of split 1 (TLE1) corepressor as a therapeutic target for LUAD.

PI_NAMEs: BILIRAN, HECTOR RAMOS (contact)

PROJECT_TERMS: Address;Adenocarcinoma Cell;Affect;Aggressive behavior;Agreement;Anchorage-Independent Growth;Anoikis;Apoptotic;Automobile Driving;Award;Binding;Bioinformatics;Bite;bronchial epithelium;Cancer Etiology;cancer therapy;Cell Line;Cell membrane;Cell Nucleus;Cell-Matrix Junction;Cessation of life;ChIP-seq;Chromatin;chromatin remodeling;Complex;Cytoplasm;Data;Development;Diagnosis;Drug resistance;druggable target;E-Cadherin;Enhancers;Enzymes;Epigenetic Process;epigenetic silencing;Epithelial Cells;Epithelium;Event;Gene Expression;gene network;gene repression;Gene Silencing;Genes;Genetic;genetic corepressor;Genetic Transcription;Grant;Growth;Histologic;Histone Deacetylase;Human;In Vitro;in vivo;inhibitor;insight;Integrins;Laboratories;Lung;Lung Adenocarcinoma;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Mediator;Mesenchymal;Mitochondria;Modeling;Molecular;Molecular Target;molecular targeted therapies;Mus;mutant;Neoplasm Metastasis;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;Nuclear;Nuclear Translocation;Oncogenes;Oncogenic;overexpression;patient prognosis;Patients;Phenotype;Principal Investigator;prognostic value;programs;promoter;Proteins;recruit;Research Assistant;Resistance;Role;Signal Pathway;Squamous cell carcinoma;Stimulus;Students;Survival Rate;Testing;therapeutic target;transcription factor;Transcriptional Regulation;transcriptome sequencing;Transducin;Transgenic Mice;tumor;tumor progression;Tumor Suppressor Proteins;tumorigenesis;tumorigenic;Tumorigenicity;undergraduate research;undergraduate student;Work;Xenograft Model


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

PROJECT_TERMS: Antimycobacterial Agents;Bacterial Genes;Biochemical;Biological;Biological Process;cell envelope;Cell Wall;Chemicals;Citric Acid Cycle;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Color;Communities;comparative;comparative genomics;CRISPR interference;Data;Data Set;Databases;Diagnostic;Drug Controls;Drug resistance;Epidemic;experimental study;gene discovery;gene function;Gene Silencing;gene synthesis;Genes;Genetic;Genetic study;Genetic Variation;genome sequencing;genome wide association study;genome-wide;Genomics;Genus Mycobacterium;Goals;High Pressure Liquid Chromatography;Human;Immune;Immune response;in vivo;Individual;individual patient;Infection;insight;Knowledge;Laboratories;Link;lipid biosynthesis;lipidome;lipidomics;Lipids;Maps;Mass Spectrum Analysis;Membrane;Membrane Lipids;Metabolic;Metabolism;metabolomics;Mus;mycobacterial;Mycobacterium tuberculosis;mycolate;Names;Nature;novel diagnostics;novel strategies;novel therapeutics;Organism;Outcome;overexpression;Pathway interactions;Patients;Pattern;Penetration;Pharmaceutical Preparations;Phenotype;Population;pressure;programs;Research Personnel;Robin bird;Role;selective expression;South Africa;Structure;Testing;transmission process;Tuberculosis;Tuberculosis diagnosis;tuberculosis treatment;Validation;Variant;Virulence;Virulent;whole genome;Whole Organism;Wood material

PROJECT_TITLE: Study of M. tuberculosis under human host selection to identify virulence and barrier lipids (Project 1)


ORG_CITY: SEATTLE

ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

ORG_STATE: WA

PHR: Low back pain (LBP) is second only to hearing problems as a reason for Veteran disability, and it is the most common cause of disability globally. Although general activity is encouraged in the treatment of LBP, there is very little information on the specific types of activities that are beneficial or harmful for patients seen in primary care for a new episode of LBP. We propose a study using innovative design and analysis methods, and modern mobile health and actigraphy technology, to identify the short-term and overall effects of different types of physical activities on LBP outcomes among Veterans in VA primary care. This work will provide completely new, foundational information that will support Veterans with LBP in navigating the complex process of recovery. It will also help VA doctors to make recommendations regarding return to work and activities for those with LBP. Our proposed research responds directly to the Rehabilitation Research and Development service’s call for research into activity-based treatments for chronic pain.

PI_NAMEs: SURI, PRADEEP  (contact)

PROJECT_TERMS: Accounting;actigraphy;Age;Analgesics;Benign;biopsychosocial;Categories;Cessation of life;Characteristics;chronic pain management;Clinical Practice Guideline;Cohort Analysis;Cohort Studies;Complex;Cross-Over Studies;Crossover Design;Data;design;Development;disability;Disparate;Educational Intervention;evidence base;experimental study;Flare;follow-up;Frequencies;Fright;Future;Guidelines;Hearing;Hearing problem;Home;Hour;improved;Individual;innovation;interest;Intervention;Learning;Lifting;longitudinal analysis;Low Back Pain;Measures;Mental Depression;Mental Health;Methods;mHealth;Modernization;Movement;Myocardial Infarction;novel strategies;Occupational Health;Opioid;opioid misuse;opioid use;Pain;Pain intensity;pain outcome;Patients;Periodicals;Physical activity;post-traumatic stress;Primary Care;primary outcome;Process;Productivity;protective effect;Quality of life;Questionnaires;Randomized, Controlled Trials;Recommendation;Recording of previous events;Recovery;Recovery of Function;Recurrence;rehabilitation research;Research;research and development;return to use;Risk;Role;Sampling Studies;secondary outcome;Services;Stress;suicidal risk;Technology;Testing;Veterans;Work;Workplace

PROJECT_TITLE: Effects of Physical Activities on Pain and Functional Recovery in Low Back Pain

STUDY_SECTION_NAME: Musculoskeletal Health & Function[RRD2]


ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

PHR: This research will develop novel and accessible way to deliver effective and customized rehab to those suffering from common and devastating neurodegenerative condition called Parkinson’s disease. We will examine the efficacy of novel rehab technique that can be monitored and modified in real-time but over virtual interface using a remotely located device in a paradigm called dynamic cycling. This technology will benefit thousands of Veterans who need customized and cost-effective rehab but cannot travel to specialized facilities due to inevitable limitations such as pandemics or because of lack of resources, social support, frailty, or home-bound status.

PI_NAMEs: SHAIKH, AASEF G (contact)

PROJECT_TERMS: Affect;Area;Artificial Intelligence;artificial intelligence algorithm;awake;Caring;Clinic;Clinic Visits;Clinical;Cognition;Cognitive;Communication;Communities;cost effective;cost effectiveness;Data;data exchange;Deterioration;Development;Devices;Dopamine;Dose;effectiveness testing;efficacy evaluation;efficacy testing;Equilibrium;Exercise;exercise regimen;Exercise Therapy;experience;Feedback;frailty;functional decline;functional improvement;Future;Goals;Group Homes;Health Insurance Portability and Accountability Act;Health Personnel;Home;Hour;improved;Independent Living;Individual;individualized medicine;instrument;Intervention;Laboratories;Levodopa;Location;Logistics;Longterm Follow-up;Measures;Mental Depression;Monitor;Motor;motor deficit;motor function improvement;motor symptom;Movement Disorder Society Unified Parkinson's Disease Rating Scale;Movement Disorders;Nerve Degeneration;novel;Nursing Homes;Ohio;operation;Outcome;Outcome Measure;Outpatients;pandemic disease;Parkinson Disease;Participant;participant safety;Patients;Performance;Persons;Pharmaceutical Preparations;Phase;post intervention;Progressive Disease;provider intervention;Quality of life;Regimen;Rehabilitation therapy;remote assessment;remote delivery;remote health care;remote monitoring;Research;Resources;response;Safety;safety supervision;Schedule;Secure;Self Direction;sensor;Site;Social support;Speed;Strategic Planning;Symptoms;System;Techniques;Technology;Testing;therapy outcome;Time;Titrations;Torque;Travel;user-friendly;Veterans;virtual;Vision;Visit;wearable device;wearable sensor technology;wireless fidelity;wireless sensor

PROJECT_TITLE: Remote dynamic cycling for the customized off-site rehab in Parkinson’s disease.

STUDY_SECTION_NAME: Chronic Medical Conditions & Aging[RRD6]


PHR: NARRATIVE It has been estimated that 10-20% of Veterans returning from Iraq and Afghanistan have suffered a traumatic brain injury, and many have symptoms suggestive of the residual effects of mild TBIs not recognized prior to discharge. Our study focuses on the latent effects of repeated exposure to blast during operational training. We will identify the associations among biological, physiological, and psychological symptoms in Veterans who, because of their specific military occupational specialty (MOS), have had repeated occupational overpressure exposure (ROPE) and whose symptoms may include sleep disturbances and comorbid PTSD, and/or Major Depressive Disorder.

PI_NAMEs: HAGHIGHI, FATEMEH G (contact)

PROJECT_TERMS: active duty;Affect;Afghanistan;associated symptom;Authorization documentation;Biological;blast exposure;Blood specimen;Caliber;Candidate Disease Gene;Cause of Death;Chronic;circadian;Circadian Dysregulation;Clinical;Cognitive deficits;cognitive function;cohort;Collaborations;combat;comorbidity;Congresses;Data;debilitating symptom;Depressed mood;Disease;Distal;DNA Methylation;Documentation;Epigenetic Process;Evidence based intervention;Exhibits;experimental study;Exposure to;Feeling suicidal;Freedom;Future;Genes;Genetic;Genetic Transcription;Genomic approach;Goals;Headache;Health;Human Resources;Injury;Iraq;Law Enforcement;Link;Longitudinal Studies;Major Depressive Disorder;Mediating;Medical Records;medical specialties;Memory;Mental Depression;methylation pattern;mild traumatic brain injury;Military Personnel;military veteran;Molecular;Nucleic Acid Regulatory Sequences;Occupational;Occupational Exposure;operation;Pain;Participant;Pathway interactions;Pattern;Phenotype;Physiological;Policies;Post-Traumatic Stress Disorders;Predisposition;pressure;Process;Protocols documentation;Proxy;psychologic;psychological symptom;Quality of life;Recording of previous events;recruit;Reporting;Research;Research Design;Research Institute;Research Personnel;Residual state;Rifles;Risk;Risk Marker;risk mitigation;Sampling;sensor;service member;Services;Severities;Sleep;Sleep Disorders;Sleep disturbances;Specimen;Symptoms;Time;Training;Traumatic Brain Injury;Veterans

PROJECT_TITLE: Identifying DNA Methylation Alterations of Chronic Effects Of Blast and Disturbed Sleep

STUDY_SECTION_NAME: Brain Health and Injury[RRD1]


NIH_SPENDING_CATS: Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MADISON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE While there is immense therapeutic potential in using induced pluripotent stem cells to model and treat disease, the reprogramming of specified cells to the stem cell fate is slow and inefficient. By contrast, after fertilization the genomes of the specified germ cells are rapidly and efficiently reprogrammed to the pluripotent cells of the early embryo. Because cellular reprogramming both in the early embryo and in culture is driven by transcription factors with pioneering characteristics, we will define the fundamental molecular features of these unique transcription factors and in so doing provide insights into mechanisms required to rapidly generate stem-cell populations.

PI_NAMEs: HARRISON, MELISSA  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Binding;Biochemical;Cell Reprogramming;cell type;Cells;Characteristics;Chromatin;Development;Disease;DNA;Drosophila genus;Embryo;Embryonic Development;Fertilization;fly;Genetic;Genome;Genomics;Germ Cells;Goals;Image;induced pluripotent stem cell;insight;Mediating;Modeling;Molecular;novel;Nucleosomes;pluripotency;Pluripotent Stem Cells;Positioning Attribute;Process;programs;Reproducibility;Research;Role;Specific qualifier value;stem cell fate;stem cell population;System;Therapeutic;tool;transcription factor;Transcriptional Activation

PROJECT_TITLE: Genomic reprogramming in the early embryo

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: AMHERST

ORG_DEPT: PSYCHOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: PROJECT NARRATIVE Withdrawal is assumed to be a major feature of nicotine/tobacco addiction and a key factor in the difficulty people have in quitting smoking or use of electronic nicotine delivery systems (ENDS; e.g., electronic cigarettes). However, very little is known about the quality and strength of nicotine withdrawal in ENDS users or its role in driving product use. The proposed research, which will systematically and comprehensively characterize the withdrawal among daily vapers compared to daily smokers of combustible cigarettes, filling critical gaps in our understanding of ENDS dependence/abuse liability and contributing to the development of therapies for tobacco/nicotine use, the leading preventable cause of death in the US.

PI_NAMEs: HAWK, LARRY W (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: Abstinence;abuse liability;Acute;Address;Adult;Affect;Agitation;Anhedonia;Attenuated;Automobile Driving;Behavioral;behavioral pharmacology;Cause of Death;Cigarette;Cigarette Smoker;cigarette smoking;combustible cigarette;craving;Dependence;Desire for food;Diagnosis;Electronic cigarette;Electronic Nicotine Delivery Systems;Equilibrium;Evaluation;Expectancy;experimental study;former smoker;Generations;Harm Reduction;Hour;Impact evaluation;increased appetite;Individual Differences;Intervention;Investigational Therapies;JUUL;Knowledge;Laboratories;Laboratory Study;Literature;Measures;Mediating;Mediator;Metabolism;Methods;Modeling;Motivation;Nature;negative affect;Nicotine;Nicotine Dependence;nicotine exposure;nicotine use;Nicotine Withdrawal;Outcome;Participant;Patient Self-Report;Persons;PhenX Toolkit;prospective;Public Health;Publishing;Questionnaires;Randomized;Relapse;Research;Research Priority;Role;Salts;Sample Size;Sampling;Science;Sensory;sex;Sleep;Sleep Disorders;Smoke;Smoker;Smoking;smoking abstinence;smoking cessation;Subgroup;Testing;theories;therapy development;Tobacco;Tobacco Control Research;Tobacco Dependence;vaper;vaping;Visit;Withdrawal;Withdrawal Symptom;Work

PROJECT_TITLE: A controlled evaluation of abstinence-induced withdrawal and motivation to vape/smoke among daily ENDS users vs. cigarette smokers


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: BOSTON

PI_NAMEs: RHEE, KYU Y (contact)

PROJECT_TERMS: acquired drug resistance;Affect;Anabolism;Anti-Infective Agents;Antibiotic Resistance;Antimycobacterial Agents;arabinofuranose;arabinogalactan;Bacteria;Bacterial Infections;Biology;cell envelope;Cell Wall;Cell Wall Alteration;Cells;Chemicals;chemotherapy;Collaborations;combat;common treatment;Complex;CRISPR interference;Crowns;Cytosol;Data;DNA-Directed RNA Polymerase;drug action;Drug resistance in tuberculosis;drug-sensitive;Ethambutol;Evolution;Extreme drug resistant tuberculosis;genome-wide;Goals;improved;individualized medicine;innovation;Knowledge;lens;lipidomics;Measures;Mediating;Membrane Lipids;Metabolic;Modeling;Modernization;Multidrug-Resistant Tuberculosis;Mycobacterium tuberculosis;Organism;p-Aminosalicylic Acid;Penetration;Peptidoglycan;Permeability;Pharmaceutical Preparations;Pharmacotherapy;Physiological;programs;Property;Regulation;Research;Research Personnel;Resistance;response;Rifampin;Role;Structure;Structure-Activity Relationship;System;Technology;Therapeutic;tool;Tuberculosis;tuberculosis chemotherapy;tuberculosis drugs;tuberculosis treatment;Vancomycin;Variant;virtual;Virulence;Whole Organism

PROJECT_TITLE: Metabolic determinants of barrier function in rifampin-sensitive and -resistant Mtb


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: OVERALL - INBRE V: Narrative The Hawaii INBRE V network will provide a wide array of biomedical research and educational opportunities for students and emerging faculty with the long-term goal of building a diverse, sophisticated and accomplished health sciences research community in order to drive discovery ultimately leading to public health benefit relevant to the state of Hawaii.

PI_NAMEs: HOFFMANN, PETER R (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Applications Grants;Award;Bioinformatics;Biomedical Research;career;Career Choice;career development;Centers of Research Excellence;certificate program;Clinical Research;Collaborations;Communication;Communities;community college;Data;Data Science;Data Science Core;data science education;data sharing;Degree program;Development;Education;Educational Curriculum;Educational process of instructing;Employment Opportunities;experience;Faculty;faculty research;Fostering;Funding;Funding Mechanisms;Goals;hands on research;Hawaii;Health Benefit;health science research;Human;improved;Infrastructure;Institution;Instruction;instrumentation;interest;Investments;Knowledge;Leadership;meetings;Mentors;Methodology;outreach;Postbaccalaureate;Postdoctoral Fellow;Program Research Project Grants;programs;Public Health;Recruitment Activity;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Role;Science;Seasons;Structure;Student recruitment;student training;Students;success;Teacher Professional Development;Technology;Training;translational research program;undergraduate student;Universities;Workforce Development

PROJECT_TITLE: HAWAII INBRE V PROGRAM


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Administrator;Advisory Committees;Annual Reports;base;Biomedical Research;Budgets;career;career development;Career Mobility;career networking;career preparation;Collaborations;commercialization;Communication;community college;Core Facility;Country;Data Science Core;Database Management Systems;Dedications;Development;Doctor of Philosophy;education research;Evaluation;experience;Faculty;Funding Opportunities;Goals;Grant;Growth and Development function;Hawaii;Hawaiian;Human Resources;Institution;Investments;Island;Leadership;Maintenance;Manuscripts;meetings;Mentors;National Institute of General Medical Sciences;outreach;Pathway interactions;peer networks;Postdoctoral Fellow;Preparation;Principal Investigator;Program Research Project Grants;programs;Recommendation;recruit;Research;Research Design;Research Personnel;Research Proposals;Research Training;Resources;Services;Site Visit;skills;Strategic Planning;Students;success;Time;Training;Travel;undergraduate student;Universities;university student;web site;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Radiation therapy reprograms the metabolism of glioblastoma (GBM) towards the synthesis of fatty acids. Our proposed studies aim to define the consequences of such metabolic shift on the immunogenicity of irradiated GBM. Our ultimate goal is to shed light on a novel actionable target to restore brain immunity and stop GBM recurrence in the context of RT.

PI_NAMEs: VANPOUILLE-BOX, CLAIRE ISABELLE (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Abscopal effect;Acute;Adult;anti-tumor immune response;Brain;Brain Neoplasms;cancer cell;cancer therapy;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cells;Coculture Techniques;Color;Cyclic GMP;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data;Data Set;Disease;effective therapy;Effector Cell;effector T cell;Energy Supply;fatty acid biosynthesis;Fatty Acid Desaturases;fatty acid metabolism;Fatty Acids;Fatty-acid synthase;FDA approved;Flow Cytometry;Generations;Genes;Glioblastoma;Goals;Growth;Human;IFIH1;Immune;Immune Evasion;Immune response;Immune system;Immunity;immunogenic;immunogenicity;Immunologic Stimulation;Immunosuppression;Impairment;improved;in vitro testing;in vivo;Infiltration;inhibitor;innovation;Interferon Type I;Irradiated tumor;Knowledge;lipid metabolism;Malignant Neoplasms;Mediating;Metabolic;Metabolism;Modality;Modeling;Mus;Natural Immunity;novel;novel strategies;novel therapeutics;Nucleic Acids;overexpression;patient derived xenograft model;Patients;pharmacologic;Phenotype;pre-clinical;prevent;Process;Production;programmed cell death ligand 1;programmed cell death protein 1;programs;Proliferating;Property;Radiation;Radiation Oncology;radiation response;Radiation therapy;recruit;Recurrence;Recurrent tumor;Regulation;Regulatory T-Lymphocyte;Research;Resistance;resistance mechanism;response;Role;sensor;Signal Transduction;Slice;standard of care;synergism;T cell infiltration;T-Cell Activation;T-Lymphocyte;temozolomide;Testing;Therapeutic;Time;Treatment Efficacy;treatment response;Tretinoin;tumor;Tumor Immunity;tumor-immune system interactions;Up-Regulation;VEGFA gene

PROJECT_TITLE: Fatty Acid Metabolic Regulation of Anti-Tumor Immunity Against Irradiated Glioblastoma

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PI_NAMEs: WOOD, ROBIN  (contact)

PROJECT_TERMS: Address;Aerosols;antigen test;Biological;Biological Assay;Biological Markers;Biology;biomarker discovery;Blinded;Characteristics;chemotherapy;Child;Classification;Clinical;clinical development;clinical diagnosis;clinical diagnostics;cohort;comparison control;Containment;Coupled;Cryptococcus;Databases;Detection;Development;Development Plans;Diagnosis;Diagnostic;diagnostic biomarker;Diagnostic tests;Disease;drug-sensitive;Enzyme-Linked Immunosorbent Assay;Exhalation;Foundations;Goals;HIV;Human;Immunity;infection burden;lead candidate;Lecithin;Legionella;lipidomics;Lipids;lipoarabinomannan;Lung Diseases;Mass Spectrum Analysis;Measures;Metabolic;metabolic profile;Methods;Modality;Modernization;Monitor;mortality;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;noninvasive diagnosis;novel;novel diagnostics;Outcome;pandemic disease;Participant;pathogen;patient population;Patients;Performance;Phenotype;Plasma;point-of-care diagnostics;Prevalence;programs;Prospective cohort;rapid diagnosis;real time monitoring;Reporting;Research Personnel;respiratory aerosol;Respiratory Disease;response biomarker;Robin bird;Sampling;screening;Serum;small molecule;Species Specificity;Sphingomyelins;Sputum;Streptococcus;Technology;Testing;Time;tool development;transmission process;Treatment Efficacy;treatment response;Tuberculosis;Tuberculosis diagnosis;tuberculosis diagnostics;tuberculosis treatment;urinary;Urine;Vaccines;Validation;Variant;Virulence;Wood material

PROJECT_TITLE: Metabolic biomarkers of TB disease, treatment response and infectiousness


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;Neuroblastoma;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Neuroblastoma is a neural crest-derived malignancy that arises from a failure of sympathoadrenal progenitors to differentiate. We propose a completely novel approach to drive neuroblastoma differentiation by blocking the functions of CHAF1A, a major epigenetic and transcriptional regulator.

PI_NAMEs: BARBIERI, EVELINE  (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: Automobile Driving;Behavior;Biological;Cell Differentiation process;Cell Line;Cellular Metabolic Process;Cessation of life;Child;ChIP-seq;Chromatin;Chromatin Modeling;Data;Development;Differentiation Therapy;Energy Metabolism;Epigenetic Process;Event;Failure;Freezing;gain of function;Gene Expression;Genes;Genetic;Genetic Transcription;Goals;Growth;Histones;in vivo;Infant;innovation;insight;Lighting;Link;Literature;loss of function;Malignant - descriptor;Malignant Childhood Neoplasm;Malignant Neoplasms;Maps;Mediating;Metabolic;Metabolic Control;Metabolism;metabolomics;Methyltransferase;Modeling;Molecular;Molecular Chaperones;Nerve Block;Neural Crest;neuroblast;Neuroblastoma;neuroblastoma cell;novel;novel strategies;Outcome;Pathway interactions;Patients;Phenocopy;Phenotype;Polyamines;prevent;progenitor;Prognosis;programs;Proliferating;recruit;Regulation;Research;Resistance;response;Sampling;SETDB1 gene;Signal Transduction;Testing;therapy resistant;TP53 gene;Transcriptional Regulation;transcriptome sequencing;Treatment Efficacy;Tretinoin;tumor;tumor metabolism;tumorigenesis;Tumorigenicity;Undifferentiated;Work

PROJECT_TITLE: Towards Novel Differentiation Therapies for Neuroblastoma.

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Mental Health;Prevention

ORG_CITY: RONDEBOSCH

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF CAPE TOWN

PHR: PROJECT NARRATIVE The ultimate goal of this research is to evaluate the feasibility, acceptability and preliminary impact of incorporating choice in the delivery of ART support to patients who return to HIV care after an interruption, a growing population who are vulnerable to future interruptions. The development of patient-centered interventions is a key priority area to bridge remaining HIV treatment gaps in high-burden settings like South Africa. If proven to be acceptable, feasible and effective, incorporating choice in the delivery of ART support in routine, high-burden HIV care settings may be an important tool to promote patient empowerment and improve ART adherence and retention.

PI_NAMEs: PHILLIPS, TAMSIN KATE (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adherence;Adult;Africa South of the Sahara;Aftercare;AIDS prevention;antiretroviral therapy;Area;arm;Attention;Award;behavior measurement;Behavioral;behavioral and social science;behavioral economics;Behavioral Research;career;career development;Caring;Clinic;Clinical;Communities;Contraceptive Agents;Data;design;Development;Effectiveness;Effectiveness of Interventions;empowerment;Ensure;Epidemiologist;Epidemiology;Evaluation;evidence base;experience;experimental study;Family Planning;Fellowship;Funding;Future;gender behavior;Goals;Growth;Guidelines;Health;Health behavior;Health Services;high risk;HIV;HIV/AIDS;implementation measures;implementation science;improved;Individual;informant;innovation;International;Interruption;Intervention;Intervention Studies;Interview;Investigation;K-Series Research Career Programs;Leadership;Measurement;Measures;men;Mentors;Mentorship;Methods;mHealth;mhealth interventions;multidisciplinary;North Carolina;Outcome;Output;patient oriented;Patient Preferences;Patients;peer support;Pennsylvania;Persons;pilot trial;Policies;poor health outcome;Population;Postdoctoral Fellow;preference;Public Health;Qualitative Methods;Qualitative Research;Randomized;Research;Research Methodology;Research Personnel;Research Priority;Resources;Role;satisfaction;Scientist;secondary outcome;Self Efficacy;Series;Services;skills;social;South Africa;Structure;Surveys;therapy adherence;therapy design;therapy development;Time;tool;Training;Treatment outcome;United States National Institutes of Health;Universities;Viral;Woman

PROJECT_TITLE: Zikhethele - choose for you: evaluating choice-based antiretroviral therapy support for patients returning to HIV care after treatment interruption in South Africa


ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: PROJECT NARRATIVE Human mutation in the serine palmitoyltransferase complex under study in this proposal underlies hereditary sensory neuropathy type 1 and early-onset amyotrophic lateral sclerosis. Defects in sphingolipid production and homeostasis controlled by the serine palmitoyltransferase complex are often linked to neurodegenerative diseases and various cancers. A deeper understanding of the structure and mechanism of this important protein complex will lead to new therapies for neuronal dysfunctions and cancers.

PI_NAMEs: LEE, CHIA-HSUEH  (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Address;Amyotrophic Lateral Sclerosis;Anabolism;Apoptosis;Architecture;Binding;Binding Sites;Biochemical;Biochemistry;Biogenesis;Biological Process;Biology;biophysical techniques;Biophysics;Catalysis;cell growth;Cells;Complex;Cryoelectron Microscopy;Defect;Disease;early onset;Environment;Enzymes;Exhibits;Feedback;Foundations;Goals;Hereditary Sensory Neuropathy;Homeostasis;Human;Inflammation;inhibitor;insight;interdisciplinary approach;Investigation;Knowledge;Lead;Link;Lipid Binding;Lipids;Malignant Neoplasms;Mediating;Membrane;Membrane Proteins;Metabolism;Methods;Molecular;Molecular Conformation;Multienzyme Complexes;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neuronal Dysfunction;novel therapeutics;Palmitoyl Coenzyme A;Pathway interactions;Positioning Attribute;preference;Production;Protein Biochemistry;protein complex;Protein Isoforms;Reaction;Regulation;Research;Resolution;Role;sensor;Serine;serine palmitoyltransferase;Shapes;Signaling Molecule;Sphingolipids;structural biology;Structure;Substrate Specificity;Testing;Time;tumorigenesis;Visualization;Work

PROJECT_TITLE: Structural and Functional Studies of Human Serine Palmitoyltransferase Complexes

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ORG_CITY: CORAL GABLES

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project narrative KCNQ genes encode K+ channels that are mutated in epilepsy and autism and that have been linked to other neurological conditions. KCNQ channels are expressed in both neurons and glia; however, while their function in neurons is well documented and understood, little is known about their function in glia. In this proposal, in an in vivo setting, we exploit the tractability of the model organism C. elegans to establish the contribution of glial wild type and mutant KCNQ channels to the functioning of the nervous system. 1

PI_NAMEs: BIANCHI, LAURA  (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: Affect;Afferent Neurons;Alzheimer's Disease;Astrocytes;autism spectrum disorder;Behavioral;Behavioral Assay;Bipolar Disorder;Caenorhabditis elegans;cell type;Cells;Complex;Consumption;Data;Dedications;Electrophysiology (science);Encapsulated;Encephalopathies;Epilepsy;epileptic encephalopathies;experimental study;Familial benign neonatal epilepsy;Family;Functional Imaging;gain of function;gamma-Aminobutyric Acid;Genes;genetic approach;genetic manipulation;Goals;Heart;Homologous Gene;Human;Huntington Disease;Image;in vivo;Individual;knock-down;Knock-out;Link;loss of function mutation;Mammals;member;Membrane Potentials;model organism;mutant;Mutate;Mutation;Neonatal;Nervous System;Nervous System Physiology;Neuroglia;Neurologic;neuronal excitability;Neurons;neuropsychiatry;Octanols;Odors;Organ;Output;Parkinson Disease;Pathogenicity;Pathology;pharmacologic;Phenotype;Phosphatidylinositol 4,5-Diphosphate;Physiological;Potassium Channel;Property;Regulation;response;Rest;Role;Sensory;Structure;Testing;Time;transcriptome sequencing;Voltage-Gated Potassium Channel;Work

PROJECT_TITLE: Glial KCNQ channels.


ORG_CITY: GAINESVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: 290,000 individuals have a spinal cord injury (SCI) in the US. Of these, ~42,000 are eligible for treatment in the Veteran Health System. Walking impairment is a hallmark consequence of SCI. We have developed a novel multimodal therapy combining body-weight supported treadmill training and testosterone therapy and have promising preclinical evidence that demonstrates greater walking recovery than either treatment alone following severe SCI. However, the dose of testosterone exceeds a clinical dose and if awarded, this Career Development Award, will identify the lowest effective testosterone dose that produces comprehensive functional gains in an effort to limit prostate growth when used in combination with body-weight supported treadmill training. Secondly, we will evaluate hormonal mechanisms underlying this promising novel therapy to obtain the data necessary to support future clinical trials that will assess the efficacy of our multimodal therapy intended to hasten locomotor recovery and improve neuromuscular function in Veterans with SCI.

PI_NAMEs: OTZEL, DANA M (contact)

PROJECT_TERMS: Address;Adjuvant;anastrozole;Anatomy;androgenic;Animals;Area;Aromatase;Aromatase Inhibitors;Award;Body Weight;Central Nervous System;Chest;Clinical;Clinical Trials;Combined Modality Therapy;comparative efficacy;Data;Distal;Dose;efficacy evaluation;efficacy study;Eligibility Determination;Estradiol;Exhibits;experimental study;Fiber;functional adaptation;functional gain;Future;Gait abnormality;Growth;Health system;Hemoglobin;Hindlimb;Histologic;Hormonal;improved;In Situ;Individual;Injury;K-Series Research Career Programs;Lesion;Locomotor Recovery;Locomotor training;Magnetic Resonance Imaging;male;Measures;Mediating;men;Modeling;Morphology;motor disorder;Motor Neurons;Muscle;Muscle Fibers;Muscle function;neural;neuromuscular function;neuromuscular plasticity;neuromuscular stimulation;Neuronal Plasticity;neuroprotection;novel;novel strategies;novel therapeutics;Output;Paralysed;Pharmacotherapy;Physical Rehabilitation;pre-clinical;preservation;prevent;primary outcome;Prostate;prostate enlargement;Rattus;Recovery;response;Rodent;secondary outcome;Severities;sham surgery;side effect;Site;Soleus Muscle;Spinal;Spinal Cord Contusions;Spinal cord injury;Spinal Cord Lesions;success;Testosterone;Testosterone Enanthate;Translations;treadmill training;Treatment Efficacy;Veterans;Walking;white matter

PROJECT_TITLE: Influence of aromatase on neuromuscular plasticity resulting from testosterone plus locomotor training after spinal cord injury


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Data Science

PI_NAMEs: DENG, YOUPING  (contact)

PROJECT_TERMS: Acceleration;Address;Applications Grants;Attention;Award;Bioinformatics;biomedical data science;Biomedical Research;Biometry;career;career development;career preparation;certificate program;Client;Collaborations;Communities;community college;Consultations;Data;Data Analyses;data integration;data management;Data Science;Data Science Core;Data Scientist;Data Security;Development;Doctor of Philosophy;early-career faculty;Education;Educational Activities;Educational Curriculum;Educational workshop;experience;Experimental Designs;Faculty;Faculty Workshop;Fostering;Foundations;Goals;Grant;Hawaii;Health;Health Sciences;human capital;Individual;informatics tool;Infrastructure;innovation;Institution;Investigation;Life Cycle Stages;Link;Methodology;Methods;outreach;Pathway interactions;Peer Review;Postdoctoral Fellow;Program Development;programs;Publications;Research;Research Personnel;Research Project Grants;Research Support;Resources;Science;Service delivery model;Services;skills;Solid;statistics;student mentoring;Students;success;summer institute;Techniques;tool;Training;Training and Education;training data;undergraduate student;Work

PROJECT_TITLE: Data Science Core for Biomedical Research


ORG_CITY: SALT LAKE CITY

ORG_NAME: VA SALT LAKE CITY HEALTHCARE SYSTEM

ORG_STATE: UT

PHR: Project Narrative: The Veteran population is skewed in terms of age, with more than 55% of Veterans already over 65 years of age. Older individuals with deficits in muscle size, strength and power can become mobility-limited to a degree that simply walking to the mailbox is at the upper limit of their physical capacity. An age-associated vascular dysfunction leading to muscle de-conditioning, particularly in the lower extremities, has been described as a “vicious loop” as inactivity and muscle atrophy result in weakness and low power production which leads to reduced mobility and an even greater restriction of activity leading to even more pronounced vascular and muscle deterioration. The central goal of Dr. Richardson’s research is to attenuate the process of vascular aging such that fatigue resistance and impaired mobility are achieved and vascular aging continues to be attenuated. Thus, Dr. Richardson’s work has significant implications for the VA and rehabilitative medicine.

PI_NAMEs: RICHARDSON, RUSSELL S. (contact)

PROJECT_TERMS: Acceleration;Age;age acceleration;age effect;age related;Age Years;age-related disease;aged;Aging;aging process;Alzheimer's Disease;American;American Heart Association;Area;Attenuated;Award;Biological Sciences;Blood Vessels;Businesses;California;Cardiology;care costs;career;Cities;clinical center;Clinical Research;clinically relevant;Cognition;college;Coupled;Critical Care;Data;deconditioning;demographics;Development;Doctor of Philosophy;Education;Elderly;England;Extensor;Faculty;fall risk;Fatigue;frailty;Functional disorder;Funding;Geriatrics;Goals;Grant;Health;Healthcare;Healthcare Systems;human old age (65+);Immobilization;indexing;Individual;Institution;interest;Journals;Laboratory Research;Leg;Link;London;Long-Term Care;Lower Extremity;Lung;Mediating;Mediation;Medical Research;Medicine;Mentors;Mentorship;Metabolic;Metabolic Control;military veteran;Mission;Mobility decline;Muscle;Muscular Atrophy;Older Population;Paper;Peer Review;Persons;Physical Capacity;Physical Function;Physiological;Physiology;Play;Population;Postdoctoral Fellow;Process;Production;Productivity;professor;programs;Publishing;recruit;rehabilitation research;Rehabilitation therapy;Research;research and development;Research Priority;Resistance;respiratory;Role;Scientist;Services;Skeletal Muscle;Societies;Sodium Chloride;Students;Training;United States National Institutes of Health;Universities;Utah;Vascular Diseases;Veterans;Viscosity;Walking;walking speed;Work

PROJECT_TITLE: Senior Research Career Scientist

STUDY_SECTION_NAME: Research Career Scientist[RRD7]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Pediatric;Rural Health;Social Determinants of Health

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: High School Research Initiative Expansion Project Narrative Rural students and teachers are far from universities, have fewer resources, and most students are not attending college, and at the same time, there is a well-recognized need for more K-12students to pursue STEM careers. The University of Texas at Austin High School Research Initiative (HRI) Expansion Project seeks to address this need by broadening the audience and reach of the original program, leveraging the infrastructure of the HRI, including the partnerships with more than ten regional high schools and partnerships with two nationally recognized models for STEM education: The Freshman Research Initiative (FRI) and UTeach. The HRI Expansion Project seeks to enhance educational science resources, teacher training, and a community of higher ed and high school educators to promote a diverse workforce to meet the growing health science needs of the country.

PI_NAMEs: STOVALL, GWENDOLYN M (contact)

PROJECT_TERMS: Address;Area;Attitude;Awareness;Behavioral Research;Biomedical Research;career;Chemistry;Clinical Research;college;Communicable Diseases;Communication;Communities;Country;Data;design;Development;Distance Learning;Diverse Workforce;drug discovery;Education;educational atmosphere;Educational Curriculum;Enrollment;Ethics;experience;Experimental Designs;Faculty;Fostering;Geography;Health Sciences;high school;High School Faculty;higher education;Hispanic;Hybrids;improved;Infrastructure;Instruction;Knowledge;Life;Location;meetings;member;Mentors;Modeling;Molecular Biology;Motivation;Needles;New England;New York;Newsletter;North Carolina;Ohio;Organic Chemistry;peer coaching;Pennsylvania;Population;Poverty;Program Development;programs;Psychosocial Assessment and Care;Public Health;recruit;Research;Resources;Rural;rural area;Rural Community;Schools;Science;science education;science teacher;Science, Technology, Engineering and Mathematics Education;Scientific Inquiry;scientific literacy;Scientist;Self Efficacy;Services;skills;statistics;STEM career;student mentoring;Students;success;teacher;teacher mentor;Teacher Professional Development;Teaching Method;Texas;Time;Training;training opportunity;Translating;undergraduate student;Underrepresented Populations;Underserved Population;Universities;Value Orientations;Vision;Water;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lyme Disease;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: GREENVILLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: EAST CAROLINA UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Bacteria belonging to the Borrelia genus include Borrelia burgdorferi which is an infectious tick-borne spirochete that causes nearly 300,000 cases of Lyme disease in the United States annually. Borrelia are also known to cause other serious vector-borne human illnesses including relapsing fever and Borrelia miyamotoi disease. In this project is we will use structural, biochemical, and microbiological approaches to study a group of evolutionarily-related, multi-functional, borrelial lipoproteins with the goal of understanding their role in promoting bacterial survival and persistence in immunocompetent hosts.

PI_NAMEs: GARCIA, BRANDON LEE (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Ablation;Address;Affinity;Amino Acids;Animal Model;Antibodies;arm;Asia;Bacteria;Binding;Biochemical;Biological;Biological Assay;biophysical techniques;Biophysics;Borrelia;Borrelia afzelii;Borrelia burgdorferi;Borrelia burgdorferi Group;Borrelia garinii;Borrelia Infections;Borrelia miyamotoi;Borrelia turicatae;Classical Complement Pathway;Clinical;Communicable Diseases;Complement;Complement 1q;Complement Activation;Complement component C1r;complement deficiency;complement pathway;complement system;Complex;Cytolysis;Data;design;Disease;disease model;Etiology;Europe;Event;Experimental Designs;Experimental Models;Family;Genes;Genetic;Goals;Hematogenous;Homologous Gene;Human;human disease;imaging approach;Immune;Immunity;Immunocompetent;Immunomodulators;immunoregulation;Impairment;In Vitro;in vitro activity;in vivo;in vivo imaging;in vivo Model;Infection;inhibitor;interdisciplinary approach;Life Cycle Stages;Lipoproteins;Lyme Disease;lyme pathogenesis;Lytic;Measures;Mediating;Medical;Microbe;Minor;Modeling;Molecular;mouse model;multidisciplinary;Mus;mutant;Natural Immunity;Nature;Order Spirochaetales;Orthologous Gene;pathogen;Pathogenesis;Pathway interactions;Pattern Recognition;Peptide Hydrolases;Phenotype;Phylogenetic Analysis;Play;Predisposition;Proteins;Reaction;Relapsing Fever;relapsing fever borrelia;Reporting;Resolution;Role;Serum;Spirochaetales Infections;Structure;Surface;Testing;tick borne spirochete;Ticks;United States;vector-borne;vector-borne pathogen;Vector-transmitted infectious disease;Virulence;X-Ray Crystallography

PROJECT_TITLE: Virulence Mechanisms of Multifunctional Borrelial Proteins

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative: Neurotransmitter switching is a newly appreciated form of plasticity in the adult brain that can underlie both beneficial and harmful behaviors. We have found that a single stimulus can drive transmitter switching in more than a single brain region. Here we propose to use genetically-encoded fluorescent reporters to determine the full extent of transmitter switching throughout the whole brain and identify the role of patterns of electrical activity.

PI_NAMEs: SPITZER, NICHOLAS CANADAY (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TITLE: Determining Fundamental Properties of Neurotransmitter Switching in Adult Mammals


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Pediatric;Prevention

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The areas of bioinformatics, computational biology and omics are increasingly important scientific areas for which an educational gap exists within the pediatric graduate medical education (GME) training for both residents and subspecialty fellows. The Department of Pediatrics, David Geffen School of Medicine at UCLA plans to fill this gap for more specialized education and more in-depth training for pediatric GME clinical trainees both at our institution and nationwide by building experience and skills in biomedical big data analysis, promoting the establishment of multidisciplinary networks and opportunities for collaboration in these specialized areas, and thereby provide a bridge for trainees towards future funding (i.e. T32, K23, K12, K08) and successful academic careers as members of multi-disciplinary teams. This program will support research education in translational, basic, and clinical research that has the potential to advance the field and care of Pediatric patients.

PI_NAMEs: DEVASKAR, SHERIN U (contact);ENCISO, JOSEPHINE M

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Address;Area;Basic Science;big biomedical data;Big Data;big-data science;Bioinformatics;Biological Sciences;Biometry;career;Child health care;Childhood;Clinical;Clinical Medicine;Clinical Research;Collaborations;collaboratory;Complex;Computational Biology;Computational Science;Congenital Abnormality;Data Analyses;Data Set;Development;Diagnosis;Discipline;Disease;disorder risk;DNA Methylation;Doctor of Philosophy;E-learning;Education;Education Gap;education research;educational atmosphere;Educational process of instructing;Educational Status;Educational workshop;Endocrine System Diseases;epigenome;Etiology;experience;Faculty;flipped classroom;forging;Fostering;Foundational Skills;Functional disorder;Funding;Future;gene network;Genetic Diseases;genome sequencing;graduate medical education;Health;High-Throughput Nucleotide Sequencing;Hybrids;Immune System Diseases;Individual;Institution;Instruction;interest;Intervention;Journals;Knowledge;lectures;Life;Life Cycle Stages;Link;Malignant Childhood Neoplasm;Malignant Neoplasms;Medical;medical schools;member;Mentored Clinical Scientist Development Program;Mentors;Metabolic Diseases;metabolome;metagenome;microbiome analysis;Molecular;multidisciplinary;new therapeutic target;next generation;Organ;Pathway Analysis;Pathway interactions;Patient Care;Patients;pediatric department;pediatric patients;Pediatric Research;Pediatrics;Physicians;Postdoctoral Fellow;precision medicine;Prevention strategy;programs;Proteome;recruit;Research;Research Personnel;Research Support;Scholarship;Science;Scientist;single-cell RNA sequencing;skills;Systemic disease;Talents;targeted treatment;Techniques;Technology;tool;Training;Training and Education;transcriptome;Translational Research;trend;undergraduate student;whole genome

PROJECT_TITLE: UCLA Pediatric Research Education Program in Bioinformatics, Computational Biology, and Omics

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


PI_NAMEs: TURNER, HELEN C (contact)

PROJECT_TERMS: Area;Award;Benchmarking;career;catalyst;Collaborations;community college;Community of Practice;community research;Computers and Advanced Instrumentation;Core Facility;Data Science;Development;Development Plans;Educational process of instructing;Educational workshop;Equipment;Faculty;faculty mentor;faculty research;faculty support;Fostering;Funding;Funding Mechanisms;Funding Opportunities;Grant;Hawaii;Home;human capital;Immersion;Inosine Diphosphate;Institution;Investments;Knowledge;Leadership;Maps;Measures;member;Mentors;Mission;Outcome;pedagogy;Peer Review;peer support;Performance;personalized approach;Pilot Projects;Positioning Attribute;Postdoctoral Fellow;Process;Program Development;Program Research Project Grants;programs;Reporting;Research;research and development;Research Personnel;Research Project Grants;Research Training;Resources;Structure;System;Talents;Training;undergraduate research;undergraduate student;Work;Writing

PROJECT_TITLE: Developmental Research Project Program


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Hypertension;Neurodegenerative;Neurosciences;Prevention;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative We propose to study the mechanisms through which high blood pressure can produce brain blood vessel wall injury, impaired function, decreased clearance of pathological proteins (amyloid and tau), and resultant brain tissue damage, factors that can culminate into disabling dementia in older adults. The studies will be performed in patients who had a hypertensive brain hemorrhage, a known human model of severe hypertensive small vessel disease, using innovative physiological MRIs obtained in ultrahigh field strength (7T) scanners and cutting-edge molecular PET imaging. The aim is to understand the physiological and molecular mechanisms of brain tissue injury related to hypertension, that would lay the groundwork for targeted therapeutic studies to prevent dementia in older adults.

PI_NAMEs: GUROL, MAHMUT EDIP (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Adult;Age Years;Aging;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;Amyloid Proteins;Atrophic;Basal Ganglia;biomarker development;Blood Pressure;Blood Vessels;Brain;Brain Diseases;Brain hemorrhage;Brain Injuries;Brain Ischemia;Brain Pathology;brain tissue;Carbon Dioxide;Cerebral small vessel disease;Cerebrovascular Disorders;cerebrovascular reactivity;Cerebrovascular system;Cerebrum;Cessation of life;Clinical Trials Design;Cognition;Cognitive;cognitive change;cohort;Dementia;dementia risk;Deposition;Diagnosis;disability;Disabling;Exhibits;Experimental Designs;experimental study;Foundations;Functional disorder;Functional Imaging;Functional Magnetic Resonance Imaging;gray matter;Hemorrhage;human model;Hypertension;hypertensive;Hypertensive Intracerebral Hemorrhage;imaging approach;imaging biomarker;Impaired cognition;Impairment;Infarction;Injury;innovation;Ischemia;Ischemic Stroke;Lesion;Link;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;Mediating;Mediator;Methodology;Methods;Microvascular Dysfunction;Molecular;multidisciplinary;Multimodal Imaging;multimodality;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;non-demented;novel;novel marker;older adult;Pathologic;Pathology;Patients;Physiological;Physiology;Pittsburgh Compound-B;Population;Positron-Emission Tomography;preservation;prevent;Preventive;Process;Proteins;Randomized, Controlled Trials;Recommendation;Research;Research Priority;Risk Factors;Severities;Severity of illness;Source;Stimulus;structural imaging;Survivors;symposium;targeted treatment;tau aggregation;tau Proteins;Testing;Therapeutic;Therapeutic Studies;tissue injury;United States;United States National Institutes of Health;Vascular Cognitive Impairment;vascular cognitive impairment and dementia;Vascular Dementia;Vascular Diseases;white matter;White Matter Hyperintensity

PROJECT_TITLE: Molecular and Physiological Mechanisms of Hypertensive Cerebral Microangiopathy

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Palliative Care

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: NARRATIVE The aim of the Short-Term Aging-related Research (STAR) Program is to provide select first year medical students at the University of Chicago Pritzker School of Medicine with a structured mentored summer research experience in aging, coupled with didactic and experiential training in the care of older adults. Through this experience, we hope to prepare and inspire the next generation of physicians to understand and improve care for older adults through scholarship & discovery.

PI_NAMEs: ARORA, VINEET ;MELTZER, DAVID O (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Academy;Aging;aging related;Alzheimer's Disease;Basic Science;Behavior;Biology;career;Caring;Clinical;Clinical Sciences;Evaluation;Funding;Geriatrics;healthy aging;improved;Individual;innovation;Instruction;interest;Investigation;Medical Education;medical schools;Medical Students;Medicine;member;Mentors;next generation;older adult;Older Population;Palliative Care;Participant;peer;Physicians;Population;Principal Investigator;Process;programs;Research;Research Infrastructure;Research Personnel;Research Training;responsible research conduct;Running;Scholarship;Schools;Scientific Inquiry;Scientist;Sleep;social science research;Social Sciences;statistics;Students;summer research;Training;Training Programs;United States National Institutes of Health

PROJECT_TITLE: Short Term Aging-Related Research Program


PI_NAMEs: HOFFMANN, PETER R (contact)

PROJECT_TERMS: career;career networking;career preparation;community college;Data Science Core;Development;education research;experience;Goals;Hawaii;Institution;Pathway interactions;peer networks;programs;Research;Research Personnel;Research Project Grants;Role;Services;Students;Training;undergraduate research;undergraduate student;university student;Work

PROJECT_TITLE: PATHway for Biomedical Careers Program