NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Pediatric;Prevention

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Children infected with SARS-CoV-2 are frequently reported to have co-infection with other respiratory viruses, which potentially results in worse COVID-19 clinical outcomes. Here, we propose to leverage a biobank of residual diagnostic specimens from children with COVID-19 to determine the prevalence of respiratory viral co- infection, its association with clinical outcome, its influence on the host immune response, and its influence on viral evolution. These data will help inform best practices in diagnosis and treatment of respiratory virus co- infection to minimize child and adolescent morbidity and mortality.

PI_NAMEs: COATES, BRIA M;HULTQUIST, JUDD F (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 2019-nCoV;Adolescent;Adult;adverse outcome;Algorithms;Anti-viral Agents;Anti-viral resistance;Anti-viral Therapy;Antibodies;biobank;Biological Assay;breakthrough infection;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Child;Childhood;Clinical;Clinical Data;co-infection;cofactor;comorbidity;Computerized Medical Record;COVID-19;COVID-19 diagnostic;COVID-19 patient;COVID-19 prevalence;COVID-19 vaccination;cytokine;Data;demographics;design;Detection;Development;Diagnosis;Diagnostic;Disease;Disease Outcome;Distance Learning;Drug Targeting;Enterovirus;evidence base;Evolution;experience;Family;Frequencies;Genetic Variation;genome sequencing;Goals;Human;Human Metapneumovirus;Hybrids;Immune;Immune Evasion;Immune response;Immunity;Incidence;Individual;Infection;Inflammation;Inflammatory;influenzavirus;Injury;Interleukin-6;Link;Lymphopenia;Measurement;Measures;Metadata;Modeling;Morbidity - disease rate;mortality;Mucosal Immune Responses;Mucous Membrane;Mutation;Nasopharynx;next generation sequencing;Outcome;parainfluenza virus;pathogen;Pathway interactions;Patients;Pediatric Hospitals;Phylogenetic Analysis;Policies;Population;pressure;Prevalence;Prevention;prospective;Public Health;Recording of previous events;Relaxation;Reporting;research clinical testing;Residual state;Resistance;respiratory;Respiratory Mucosa;respiratory pathogen;Respiratory syncytial virus;Respiratory Tract Infections;respiratory virus;response;Rhinovirus;Risk;Risk Factors;SARS-CoV-2 infection;severe COVID-19;Severity of illness;single-cell RNA sequencing;Site;social learning;Specimen;Testing;Time;transcriptome sequencing;transcriptomics;Upper respiratory tract;Vaccination;Variant;Viral;viral genomics;Viral Load result;Virus;Virus Diseases;whole genome

PROJECT_TITLE: Viral and Host Dynamics during Pediatric COVID-19 and Respiratory Virus Co-Infection

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease;Microbiome;Nutrition

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE The proposed studies are based on observation showing that therapeutic inhibition of a specific mechanism of intestinal leakiness reduces severity of experimental inflammatory bowel disease. The goals are to understand the mechanisms by which this occurs and to develop structural data that will enable development of targeted therapeutic agents.

PI_NAMEs: TURNER, JERROLD R. (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: absorption;Acute;Advanced Development;Affect;Animal Experiments;Back;Binding;Biology;Cells;Chemicals;Chronic;claudin 4;Clinical;Colitis;Consumption;Cultured Cells;Data;Development;Diet;dietary;dietary excess;dietary salt;Disease;drug development;dysbiosis;effective intervention;epidemiology study;Epithelium;Equilibrium;Exposure to;Feedback;Food;Frequencies;Genetic;Goals;Guidelines;gut microbiota;high salt diet;IL17 gene;Immune;Immune system;In Vitro;in vivo;Incidence;Inflammation;Inflammatory;Inflammatory Bowel Diseases;inhibitor;Injury;interest;intermolecular interaction;intestinal epithelium;Intestinal Mucosa;Intestines;Knock-out;Lamina Propria;Link;Mediating;microbial;microbiome;microbiota;Modeling;Molecular;Mucosal Immunity;Mucositis;Mucous Membrane;Multiple Sclerosis;Mus;network architecture;nutrient absorption;Osmolalities;Outcome;overexpression;Pathogenicity;Pathway interactions;Pharmaceutical Preparations;pharmacologic;polymerization;Polymers;Process;Production;Proteins;Recycling;Regulatory T-Lymphocyte;Reporting;salt intake;Severities;Severity of illness;Signal Transduction;small molecule;Sodium Chloride;Stimulus;Structure-Activity Relationship;synergism;T cell infiltration;T-Lymphocyte;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Agents;Tight Junctions;Tissues;Transgenic Mice;Transgenic Organisms;Translations;Transmembrane Domain;Up-Regulation

PROJECT_TITLE: Mechanisms and pathophysiologic impact of claudin-2 modulation

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stroke

ORG_CITY: ANN ARBOR

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative This project extends the highly successful Brain Attack Surveillance in Corpus Christi (BASIC), the only population-based stroke study in Mexican Americans, to study thirty-year stroke epidemiology trends. For the first time, BASIC will move beyond a focus on ethnic group differences and employ a within-Mexican American design and qualitative methods to identify key factors and social determinants of health associated with more favorable stroke outcomes and utilization of post-stroke healthcare. The results will give insight into new ways to reduce ethnic stroke disparities.

PI_NAMEs: LISABETH, LYNDA D (contact);MORGENSTERN, LEWIS B

PROGRAM_OFFICER_NAME: BENSON, RICHARD T

PROJECT_TERMS: Age;age related;Age Years;Big Data;Cognitive;cohort;Communities;culturally appropriate intervention;Data;data acquisition;Data Linkages;data resource;Data Set;design;Disparity;Emergency department visit;Epidemiological trend;ethnic difference;ethnic disparity;Ethnic Origin;Ethnic Population;Family;Focus Groups;Health;health care service utilization;health disparity;health equity;Healthcare;hospital readmission;improved;Incidence;Individual Adjustment;innovation;Inpatients;insight;Intervention;Investigation;Latinx;Latinx population;Link;Long-Term Care;Medicaid;Medicare;Mental Health;Methods;Mexican Americans;Minority Groups;Modeling;Monitor;mortality;Neurologic;Not Hispanic or Latino;novel;Outcome;Outcome Assessment;Patient Outcomes Assessments;Patients;Persons;Pharmaceutical Preparations;Population;population based;Population Study;post stroke;primary care visit;Provider;Psychosocial Factor;Qualitative Methods;Quality of life;Recommendation;Recurrence;Rehabilitation therapy;resilience;resilience factor;Resources;Risk;Role;social culture;social determinants;social health determinants;Stroke;stroke incidence;stroke outcome;Stroke prevention;stroke survivor;Subgroup;Texas;Time;trend;United States;Update;Visit;Work

PROJECT_TITLE: Brain Attack Surveillance in Corpus Christi (BASIC) Project

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EPH-A (02)]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Racial disparities in autism have been consistently identified, but we have failed to examine the role that racism plays in the lives and outcomes of Black parents and their autistic children. This study will use a mixed methods design to capture both breadth (using a large quantitative sample of 300 families) and depth (using focus groups) of the complex interactions of race, racism, class, disability, and cultural assets. This research is likely to exert a significant impact on the field because it examines both the risk and resilience of a historically marginalized group and informs future tailored intervention approaches by gaining key insight of how the Black experience impacts rearing an autistic child of color.

PI_NAMEs: BOYD, BRIAN ANTONIO (contact);IRUKA, IHEOMA U

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: Address;Advocacy;Advocate;Affect;Age;Area;Attention;autism spectrum disorder;autistic;autistic children;Behavior;Black American;Black race;Capital;caregiver strain;Caregivers;Child;Child Behavior;Child Development;Child Rearing;Child Support;children of color;Color;Communities;community partners;Complex;Cross-Sectional Studies;culturally appropriate intervention;Data;design;Diagnosis;disability;Discrimination;Disparity;Divorce;empowerment;Ethnic Origin;Exclusion;Exhibits;expectation;experience;Exposure to;Family;Focus Groups;Future;Growth and Development function;Health;Heterogeneity;Inequity;Inferior;insight;Institutional Racism;Intellectual functioning disability;Intervention;intervention delivery;Knowledge;Link;marginalization;marginalized population;Measures;Mental Health;Methodology;Methods;Mothers;Outcome;Parent-Child Relations;Parents;peer;Personal Satisfaction;physical conditioning;Play;Poverty;Preparation;Prognosis;promote resilience;Qualitative Methods;Quality of life;Race;racial bias;racial disparity;racial population;racism;recruit;Research;Research Design;Research Methodology;research study;resilience;Risk;Role;Sampling;segregation;Service delivery model;Services;social;social capital;social exclusion;social health determinants;Social Network;Socialization;Specificity;Stress;Trauma;Work

PROJECT_TITLE: Racism and Resilience Among Black Autistic Children and Caregivers

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: AI

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Nanotechnology;Vaccine Related

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative The objective of the proposed work is to study the immunogenicity of lipid nanoparticles (LNPs) and to map out the relationship between lipid structures and their inflammatory responses. The success of this work will provide a fundamental understanding of the immunogenicity of LNPs, identify lipid components responsible for LNP immunogenicity, and offer principles for the design of low-immunogenicity LNPs for a broad range of applications from vaccines to therapeutics.

PI_NAMEs: JIANG, SHAOYI  (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Acceleration;Adverse effects;Adverse event;Amines;Antibodies;B-Lymphocytes;Biological Assay;Blood;Bone Marrow;Cancer Vaccines;Cell Maturation;Cells;Charge;chemical property;Chemistry;Clinical;clinical translation;clinically relevant;Collaborations;college;COVID-19 vaccine;cytokine;Dendritic Cells;Dermatitis;design;Drug Kinetics;Ensure;Evaluation;Formulation;Gene Expression Profiling;Genetic Medicine;Guidelines;Hepatotoxicity;Human;human data;Hydration status;Immune;immune activation;immune cell infiltrate;Immune response;Immune system;immunogenicity;Immunologics;Immunology;Immunology procedure;In Vitro;in vivo evaluation;Individual;inducible gene expression;Inflammatory Response;Injections;inorganic phosphate;Intramuscular;Intramuscular Injections;intravenous injection;Investigation;Knock-out;Knockout Mice;Libraries;lipid nanoparticle;Lipids;Longevity;Macrophage;Maps;Measures;Mediating;Medicine;Messenger RNA;Microbiology;Moderna COVID-19 vaccine;Mononuclear;Mus;nanocarrier;nanomaterials;Outcome;Pathway interactions;Performance;Peripheral;Peripheral Blood Mononuclear Cell;Phenotype;Phospholipids;Polyethylene Glycols;Polymers;Population;professor;Proteins;Proteomics;receptor;Receptor Activation;Reporter;Reporting;response;RNA vaccine;Safety;screening;side effect;Site;Structure;Structure of germinal center of lymph node;subcutaneous;success;systemic toxicity;Technology;tertiary amine;Testing;Therapeutic;Toll-like receptors;Toxic effect;transcriptome sequencing;Transfection;Vaccinated;Vaccines;Veterinary Medicine;Wild Type Mouse;Work

PROJECT_TITLE: Immunogenicity of lipid nanoparticles

STUDY_SECTION: INN

STUDY_SECTION_NAME: Innovations in Nanosystems and Nanotechnology Study Section [INN]


NIH_SPENDING_CATS: Digestive Diseases;Liver Disease;Regenerative Medicine

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: NARRATIVE This project is important for public health because it will lay the foundation for better treatments for liver injury. Acute liver failure is a devastating illness with limited treatment options. This project will improve understanding of natural, endogenous repair processes in the liver so we can exploit them to improve patient outcomes.

PI_NAMEs: MCGILL, MITCHELL RYAN (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Acetaminophen;acetaminophen overdose;acetaminophen-induced liver injury;Acute Liver Failure;acute liver injury;beta catenin;Binding;Biological;Blood Vessels;Cell membrane;Cessation of life;cytokine;Data;Development;Disease;Endoplasmic Reticulum;extracellular;Face;Foundations;genetic approach;Glycerophospholipids;glycogen synthase kinase 3 beta;Goals;Graft Rejection;Growth Factor;Hepatocyte;Immunohistochemistry;Immunosuppression;improved;In Vitro;in vivo regeneration;Infection;Injury;insight;interest;Kidney Failure;Laboratories;Life;Lipid Binding;lipid metabolism;lipidomics;Lipids;Liver;liver cell proliferation;liver injury;Liver Regeneration;liver transplantation;Location;mass spectrometric imaging;Mass Spectrum Analysis;Mediating;Membrane;Membrane Lipids;Methods;mimetics;mortality;mouse model;Mus;Natural regeneration;novel;novel therapeutic intervention;Organ Donor;Pathway interactions;Patient-Focused Outcomes;Pharmaceutical Preparations;Phosphatidic Acid;Phospholipid Metabolism;Phospholipids;Phosphorylation;Phosphotransferases;post-transplant;Process;Proteins;Public Health;Records;Recovery;recruit;Regenerative response;Regulation;repaired;Research;Risk;Role;Second Messenger Systems;Serine;Signal Pathway;Signal Transduction;STK11 gene;Supportive care;Testing;tissue regeneration;tissue repair;transcription factor;Transplant Recipients;Transplantation;WNT Signaling Pathway;Work

PROJECT_TITLE: The role of phosphatidic acid in liver regeneration after acetaminophen overdose

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: NEW YORK

ORG_DEPT: BIOLOGY

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative Drosophila, with its genetic amenability and small brain size, yet sophisticated behavior, has been very successfully developed as a model system to study how neural circuits form. We investigate how neuronal diversity is generated in the fly optic lobes that contain circuits that are repeated multiple times to maintain retinotopy, and are comprised of multiple cell types. We will define the molecular mechanisms that specify the different neurons that process various aspects of visual information, and define principles that will be applicable to other neural systems in more complex organisms.

PI_NAMEs: DESPLAN, CLAUDE  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Abnormal coordination;Address;Affect;Alleles;Apoptosis;ATAC-seq;Behavior;Bioinformatics;Biological;Biological Models;Brain;brain size;Cell Cycle;Cell Death;cell type;Complement;Complex;Development;Dorsal;Drosophila genus;epigenetic memory;Exhibits;Eye;flexibility;fly;Frequencies;Funding;Generations;Genetic;genetic manipulation;Genetic Transcription;Investigation;Length;Link;Machine Learning;Mammals;Measures;Memory;Mitosis;Modeling;Molecular;Morphology;Mus;mutant;nerve stem cell;neural;neural circuit;neural patterning;neuroblast;Neuroepithelial;Neuroepithelial Cells;neuroepithelium;Neuroglia;neuromechanism;neuronal circuitry;Neurons;notch protein;Optic Lobe;Organism;Output;Paper;Pattern;Post-Transcriptional Regulation;Probability;Procedures;Process;Production;programs;Publications;Radial;Regulation;Resolution;Retina;retinal neuron;retinal progenitor cell;RNA Interference;RNA Stability;Role;Series;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;Small Nuclear RNA;spatial memory;spatiotemporal;Specific qualifier value;Speed;stoichiometry;Structure;System;Testing;Time;transcription factor;Translations;transmission process;visual information;visual processing;Work

PROJECT_TITLE: Mechanisms of neural patterning and the generation of neural diversity in the brain

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Sinus node dysfunction (SND), a common disease that results from failure of the heart’s natural pacemaker, cannot be prevented or reversed with current treatments. This project leverages stem cell technology and innovative mouse models to define the molecular mechanism that form the cells in the heart’s natural pacemaker. This research will identify new molecular pathways and targets that could eventually be used to treat patients with SND without requiring permanent pacemaker implants.

PI_NAMEs: VEDANTHAM, VASANTH  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Adopted;Adoption;Affect;Anatomy;Architecture;Area;Autonomic nervous system;Biological;Cardiac;Cardiac Myocytes;Cardiac pacemaker;cell type;Cells;Chromatin;cofactor;Coupling;Data;Data Set;Development;differentiation protocol;Disease;Down-Regulation;Enhancers;Foundations;Gene Expression;Gene Modified;Genes;Genetic;Genetic Transcription;Genomics;Goals;Head;Heart;Heart Atrium;Heart failure;heart rhythm;Human;human induced pluripotent stem cells;Implant;implantation;In Vitro;in vivo;Inferior;innovation;insight;Maintenance;Maps;Mediating;Modeling;Modification;Molecular;mouse model;multiple omics;multipotent cell;Mus;NF1 gene;novel;novel strategies;nuclear factor 1;Pacemakers;Pathway interactions;Patients;Phenotype;Play;Population;prevent;Process;progenitor;programs;Protocols documentation;Research;response;Right atrial structure;Role;Shapes;Sick Sinus Syndrome;single cell sequencing;Sinoatrial Node;stem cell population;stem cell proliferation;stem cell technology;stem cells;Structure;Superior vena cava structure;System;Tail;Time;Tissues;tool;transcription factor;Transcription Factor AP-1;Transcriptional Regulation;transcriptomics;Transitional Cell;transmission process;Validation;WNT Signaling Pathway;Work

PROJECT_TITLE: Transcriptional Regulation of Sinoatrial Node Development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDD-Q (81)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Physical Injury - Accidents and Adverse Effects

ORG_DEPT: ORTHOPEDICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE Rotator cuff disease is a significant clinical problem affecting millions of individuals each year. Rotator cuff tears require repair of tendon to bone, yet successful healing is rarely achieved. Our aim is to translate our recent discoveries on the role of the bursa in rotator cuff healing into treatments for improving outcomes after rotator cuff repair.

PI_NAMEs: THOMOPOULOS, STAVROS  (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Acromion;Acute;Address;Adrenal Cortex Hormones;Affect;Animals;Belief;Biological;Biological Products;Biology;Biomechanics;Blood Platelets;bone;Bone Resorption;Caring;Cells;Clinical;clinical practice;Communication;cytokine;Data;Dexamethasone;direct application;disability;Disease;Drug Delivery Systems;Environment;Failure;Fibrocartilages;Fluorescent in Situ Hybridization;Friction;Head;healing;Health;Histology;human old age (65+);Immunohistochemistry;immunoregulation;Impaired healing;improved;improved outcome;In Vitro;in vivo;Incidence;Individual;Inflammation;Inflammatory;infraspinatous muscle;inhibitor;Injury;Knowledge;Location;Mechanics;Mediating;Mesenchymal Stem Cells;microCT;Minor;Modeling;Molecular;Natural regeneration;novel;older patient;Operative Surgical Procedures;Outcome;Pain;paracrine;Paracrine Communication;Pathology;patient population;Patients;Pattern;pharmacologic;Plasma;Population;Positioning Attribute;prevent;Rattus;recruit;Regulation;Rehabilitation therapy;repaired;response;Role;Rotator Cuff;rotator cuff tear;Shoulder;Shoulder Pain;Signal Transduction;single-cell RNA sequencing;supraspinatus muscle;Surface;targeted treatment;Tendinopathy;Tendon structure;Therapeutic;therapeutic evaluation;therapeutic target;Tissues;transcriptomics;Translating;United States;Visualization

PROJECT_TITLE: The role of the subacromial bursa in rotator cuff degeneration and healing

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Racial and Ethnic Minority Health Research;Sleep Research

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Obstructive sleep apnea (OSA) is a common disorder with adverse health outcomes that can be life threatening when inadequately treated, particularly among African American patients. Continuous positive airway pressure (CPAP) is effective in treating moderate to severe OSA, yet few African American patients use it regularly. This proposal seeks to determine the efficacy of a couple-oriented multi-modality intervention for African American patients with OSA and their bed partners on CPAP adherence, duration and quality of sleep, functional status, and quality of life.

PI_NAMEs: THORNTON, JOHN DARYL (contact)

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: Adherence;Adult;Affect;African American;African American population;Age;Apnea;Arousal;Beds;Behavior Therapy;Behavioral;Certification;Cognitive;community based participatory approach;Continuous Positive Airway Pressure;Coronary Arteriosclerosis;Couples;Couples Therapy;Data;Development;Diagnosis;Disease;Dose;Drowsiness;Education;effective therapy;efficacy evaluation;Evaluation;exhaustion;experience;follow-up;Frustration;functional status;Future;Guidelines;Health;Health Personnel;Healthcare Systems;Hour;Hypertension;improved;improvement on sleep;Intervention;Interview;Knowledge;Life;Longterm Follow-up;Masks;Measures;Mediating;Medicine;Modeling;Morbidity - disease rate;mortality;multi-component intervention;novel;Obstructive Sleep Apnea;Outcome;Patients;Personal Satisfaction;Persons;pilot test;prevent;primary outcome;programs;Provider;Psychologist;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;remote monitoring;response;secondary analysis;secondary outcome;Self Efficacy;Site;skills;Sleep;Sleep Deprivation;Sleep Disorders;sleep health;sleep quality;Standardization;Support Groups;tailored text messaging;Therapeutic Intervention;Time;Training;treatment arm;treatment as usual;trial design;Urban Health;usual care arm;vehicular accident;virtual;Visit;Work

PROJECT_TITLE: Engaging African American Couples in the Management of Obstructive Sleep Apnea

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Biomedical Imaging;Digestive Diseases;Infant Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

ORG_CITY: WINSTON-SALEM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Necrotizing enterocolitis is a devastating intestinal disease affecting premature infants that presents significant clinical diagnostic difficulties due to the challenging disease and clinical setting. Advanced diagnostic imaging modalities are not routinely available for use in the fragile NICU patient population at risk for NEC and diagnostic confidence limits timely NEC diagnosis and effective medical management. This application investigates the development of new advanced non-invasive imaging and analysis methods to characterize biophysical physiological indicators of neonatal intestinal health and disease that presents significant translational opportunity to improve the quality of care in the NICU.

PI_NAMEs: WEIS, JARED ANTHONY (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Affect;Animal Model;Biological Markers;biophysical properties;Biophysics;Blood Vessels;Brain Hypoxia-Ischemia;Caring;Clinical;clinical diagnostics;clinical investigation;clinical translation;clinically relevant;combat;Contrast Media;Data;Death Rate;density;deoxyhemoglobin;design;Detection;Development;Diagnosis;Diagnostic;Diagnostic Imaging;Diagnostic Procedure;Disease;Disease Progression;Early Diagnosis;Early Intervention;Epithelium;Excision;Health;high risk;Histologic;Human;Hypoxia;Image;Image Analysis;imaging detection;imaging modality;Immune response;Impairment;improved;Infant;Inflammation;Inflammatory;innovation;insight;intestinal barrier;Intestinal Diseases;Intestinal Motility;Intestines;Investigation;Ischemic Bowel Disease;Life;Measurement;Measures;Medical;Methodology;Methods;Molecular;Monitor;Morbidity - disease rate;mortality;Motility;motility disorder;multidisciplinary;Necrosis;Necrotizing Enterocolitis;Neonatal;neonatal health;Non-Invasive Detection;non-invasive imaging;novel;Onset of illness;Operative Surgical Procedures;Outcome;Pathogenicity;Pathology;Patient Care;patient population;Peristalsis;photoacoustic imaging;Physiological;Pneumoperitoneum;Population;Populations at Risk;Positioning Attribute;pre-clinical;preclinical study;Premature Infant;prevent;pup;Qualifying;Quality of Care;quantitative imaging;radiological imaging;Rattus;Reaction;Research Design;Rodent Model;Staging;success;Survival Rate;Testing;Therapeutic;Time;tissue oxygenation;Tissues;Translating;translational potential;validation studies

PROJECT_TITLE: Photoacoustic Imaging for Biophysical Physiological Indicators of Neonatal Intestinal Health and Necrotizing Enterocolitis

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Diabetes;Immunotherapy;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: COLLEGE STATION

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

ORG_STATE: TX

PHR: Narrative  Type 1 diabetes (T1D) is an autoimmune disease wherein a loss in immune tolerance leads to the progressive destruction of insulin-producing β cells, resulting in hyperglycemia and complications, but there is no cure for T1D. This proposal will investigate whether extracellular vesicles (EVs) produced by mesenchymal stem cells (MSCs) can induce immune tolerance, thereby ablating T1D-associated autoimmunity. The success of the proposed research will provide essential insights and valuable information for the rational design of EV- based interventions, ultimately leading to the development of novel, safe and clinically feasible cell-free therapy using MSC-derived EVs for T1D treatment.

PI_NAMEs: LEE, RYANG HWA  (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Ablation;Acceleration;Adherent Culture;Adoptive Transfer;Antibodies;Autoimmune Diseases;Autoimmunity;autoreactive T cell;Azides;B-Lymphocytes;Beta Cell;Biodistribution;CD3 Antigens;CD4 Positive T Lymphocytes;Cells;Clinical;clinical application;Clinical Trials;comparison control;Data;Data Engineering;Development;Diabetes Mellitus;diabetic;Disease remission;Dose;Engineering;Engraftment;extracellular vesicles;Fc Receptor;functional group;Genes;Genetic Engineering;genotoxicity;Goals;high risk;Hyperglycemia;Immune;Immune Tolerance;Immunoglobulin G;immunological intervention;immunoregulation;Immunotherapy;improved;In Vitro;in vivo Model;Inbred NOD Mice;insight;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;Intervention;Label;Ligands;Literature;Mediating;Mesenchymal Stem Cells;Metabolic;MicroRNAs;Monitor;Monoclonal Antibodies;monolayer;mouse model;non-diabetic;novel;novel therapeutic intervention;Outcome;overexpression;Particle Size;Patients;Plasmids;Play;polypeptide;pre-clinical;Pre-Clinical Model;Prediabetes syndrome;Prevention;programmed cell death protein 1;Proteins;rational design;Regulatory T-Lymphocyte;Remission Induction;Reporting;Research;response;Role;Safety;side effect;success;System;T-Lymphocyte;Testing;Therapeutic;Therapeutic Effect;Toxic effect;Transforming Growth Factor beta;Viral

PROJECT_TITLE: Engineered extracellular vesicles derived from mesenchymal stem cells for the treatment of type 1 diabetes

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Precision Medicine

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Targeted therapies have improved lung cancer patient survival, but not all tumors harbor druggable targets and those that do invariably develop drug resistance. New drug targets are needed that could be used alone or in combination with existing therapies to improve patient survival. Here we will develop a new therapeutic approach based on a concept called “synthetic lethality” and validate this approach as a therapeutic strategy for suppressing cancer growth and drug resistance.

PI_NAMEs: BERGER, ALICE  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: acquired drug resistance;Acute;Antineoplastic Agents;Automobile Driving;Biological Assay;Biological Markers;cancer cell;Cancer Etiology;Cancer Patient;cancer therapy;Cell Line;cell type;Cells;Cessation of life;chemotherapy;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Computational Biology;Computer software;CRISPR screen;CRISPR/Cas technology;cytotoxicity;Data;Data Science;Dependence;Development;Drug resistance;drug resistance development;Drug Targeting;druggable target;Epidermal Growth Factor Receptor;functional genomics;Gene Duplication;Gene Family;gene function;Genes;Genetic;Genetic Transcription;Genome;genome-wide;Genomics;Growth;Guide RNA;Human;Human Genome;Immune checkpoint inhibitor;Immunotherapy;improved;in vivo;inhibitor;innovation;interactive visualization;Knock-out;knockout gene;loss of function;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Methods;Mutation;new therapeutic target;Non-Small-Cell Lung Carcinoma;novel anticancer drug;novel strategies;novel therapeutic intervention;novel therapeutics;paralogous gene;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pre-clinical;precision oncology;preclinical development;preclinical efficacy;prevent;Reproducibility;Resistance;Retinal blind spot;screening;single-cell RNA sequencing;Specificity;success;Survival Rate;targeted treatment;Therapeutic;translational medicine;tumor;tumor growth;tumorigenesis;Validation;web portal;Work

PROJECT_TITLE: Expanding the cancer paralog genetic interaction map to enable precision oncology

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: Aurora

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE: Humans naturally generate sterilizing “oxidative stress” products, such as hydrogen peroxide, to attack harmful invaders. We have discovered that in order to survive, pathogenic bacteria metabolize sulfur compounds produced by macrophages during oxidative stress. We seek to understand and exploit this process in order to benefit humans. Because oxidative stress occurs in many other illnesses, research into these novel anaerobic antioxidant defenses of harmful bacteria potentially has relevance to a wide variety of other diseases.

PI_NAMEs: VAZQUEZ-TORRES, ANDRES  (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Abscess;Aerobic;Antioxidants;Bacteria;Cells;Cessation of life;Clinic;Complex;Consumption;Cysteine;cytotoxicity;Data;Diarrhea;diarrheal disease;Disease;electron donor;Electron Transport;Engineering;enteric pathogen;Equilibrium;Fermentation;Fortification;Fostering;Funding;gene product;Generations;Genes;Genetic Transcription;Genome;Glutathione;Glycolysis;Grant;Growth;HIV;Homologous Gene;Human;Hydrogen Peroxide;Hydrogen Sulfide;Hypoxia;immunosuppressed;Individual;Infection;Inflammatory;Investigation;Iron;Knowledge;Life;Macrophage;Mediating;Mediator;Metabolic;Metabolic Pathway;Metabolism;methionine sulfoxide;Molecular;monocyte;Mus;Myeloid Cells;NADPH Oxidase;neglect;non-typhoidal Salmonella;novel;Older Population;Oxidants;oxidation;Oxidation-Reduction;Oxidative Phosphorylation;Oxidative Stress;Oxidoreductase;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity Island;Pathway interactions;Persons;Phagocytes;Phylogenetic Analysis;Plasmodium;Population;pressure;Process;Production;programs;protein complex;Proteins;Proteomics;Pyruvaldehyde;Reactive Oxygen Species;Research;Research Support;Resistance;Respiration;Respiratory Burst;response;Risk;Role;Salmonella;Salmonella infections;Salmonella typhimurium;Series;Signal Pathway;Substrate Specificity;Sulfur;Sulfur Compounds;Sulfur Metabolism Pathway;Sulfur-Reducing Bacteria;Superoxide Dismutase;Systemic infection;Testing;Virulence

PROJECT_TITLE: Molecular determinants of oxidative stress in Salmonella pathogenesis

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative  A long-term goal of our research is to reveal the brain circuitry and synaptic mechanisms of visual signal processing and transformation. Because normal visual processing is compromised in a number of neurological and psychiatric disorders, such as dyslexia, schizophrenia and autism spectrum disorders, our studies will provide important insights for the understanding and treatment of these disorders.

PI_NAMEs: CANG, JIANHUA  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Animals;Arousal;Atlases;autism spectrum disorder;Behavior;Brain;brain circuitry;Calcium;candidate marker;Cell Nucleus;cell type;Cells;Data;Disease;Dyslexia;Enterobacteria phage P1 Cre recombinase;experimental study;Fluorescent in Situ Hybridization;Genetic;Goals;Image;in vivo;inhibitory neuron;innovation;insight;Location;Locomotion;Mediating;Mental disorders;Methods;Midbrain structure;Modeling;Molecular;Morphology;Motion;Movement;multimodality;Mus;Nervous System;Nervous System Disorder;neural;neural circuit;neuromechanism;Neurons;novel;object motion;optic flow;Output;Photic Stimulation;Physiological;Positioning Attribute;Process;Property;Pulvinar structure;Research;response;Retina;Retinal Ganglion Cells;Role;Running;Schizophrenia;Series;signal processing;Signal Transduction;Speed;Stimulus;superior colliculus Corpora quadrigemina;Synapses;System;Testing;Thalamic Nuclei;Time;tool;transcriptomics;Transgenic Mice;two-photon;Viral;virtual reality environment;vision development;Vision research;Visual;visual information;Visual Motion;visual processing;visual stimulus;Visual System;Work

PROJECT_TITLE: Cell Type Specific Visual Processing in the Superior Colliculus

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Translation in eukaryotic organisms represents a final point of genetic regulation. Dysregulation of translation and RNA metabolism underlies neurodegenerative diseases such as ALS and FTD. Here we combine genetics, biochemistry, biophysics and structural biology to illuminate the mechanism by which changes in RNA translation underlie ALS and FTD, providing an avenue to therapeutic intervention for these deadly diseases.

PI_NAMEs: GITLER, AARON D.;PUGLISI, JOSEPH D (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: 3' Untranslated Regions;Affect;Aging;ALS patients;Alzheimer's Disease;Alzheimer's disease related dementia;amyloid formation;Benchmarking;Binding;Binding Proteins;Biochemical;Biochemistry;biological adaptation to stress;Biological Assay;biophysical techniques;Biophysics;c9FTD/ALS;C9ORF72;Cell Nucleus;cell type;Codon Nucleotides;Complex;Coupling;Cryoelectron Microscopy;Cytoplasm;Defect;Dementia;Dipeptides;Disease;disease model;effective therapy;Equilibrium;Foundations;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Funding;Genes;Genetic;genetic approach;Genetic Screening;Human;In Vitro;in vivo;in vivo imaging;Initiator Codon;interest;Laboratories;Link;Measurement;Messenger RNA;Methodology;Methods;misfolded protein;Molecular;Molecular Chaperones;mRNA Translation;mutant;Mutation;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neurons;Nucleotides;Organism;Parkinson Disease;Pathology;Peptides;Phosphorylation;Play;Polyadenylation;Production;Protein Biosynthesis;protein degradation;protein expression;protein TDP-43;Proteins;Proteomics;proteostasis;Quality Control;Reading Frames;Regulation;ribosome profiling;Ribosomes;risk variant;RNA;RNA metabolism;RNA Splicing;RNA-Binding Proteins;Role;Scanning;single molecule;structural biology;Structure;Therapeutic Intervention;Time;Transfer RNA;Translating;Translation Alteration;Translation Initiation;Translation Process;Translational Research;Translations

PROJECT_TITLE: Defining modifiers and mechanisms of RAN translation

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Lung;Orphan Drug;Rare Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Increased endothelial cell permeability often results in tissue edema (fluid accumulation) and inflammation, which have been associated with increased death and disability in patients with acute lung injury or acute respiratory distress syndrome. Genetic deletion of the multifunctional protein Poldip2 protects against lung edema and inflammation produced by bacterial toxins and viruses. This proposal is designed to investigate the mechanism by which Poldpip2 regulates permeability, to identify how Poldip2 itself is regulated and to begin developing and testing Poldip2 inhibitors as a first step in creating new therapies.

PI_NAMEs: GRIENDLING, KATHY K (contact);HERNANDES, MARINA SORRENTINO;LASSEGUE, BERNARD

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Acute;Acute Lung Injury;Acute Respiratory Distress Syndrome;Affect;Agonist;Alzheimer's Disease;Animal Model;Animals;Anti-Inflammatory Agents;Atherosclerosis;Bacterial Toxins;Bacteriophages;Binding;Blood Vessels;blood-brain barrier disruption;cadherin 5;Cell Line;cell type;Cells;Cessation of life;Critical Pathways;Data;Databases;design;Development;Diabetes Mellitus;disability;Disease;Edema;Endothelial Cells;Endothelium;Extravasation;fascinate;Functional disorder;Genetic;Genetic Transcription;Goals;Heterozygote;improved;in silico;In Vitro;in vivo;Inflammation;Inflammatory;inhibitor;insight;interest;Investigation;Ischemic Stroke;Knowledge;Leukocytes;Lipopolysaccharides;Liquid substance;Lung;lung injury;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Mitochondria;Modeling;Modification;Molecular;Morbidity - disease rate;mortality;mouse model;Movement;Multiple Sclerosis;Mus;NADPH Oxidase;new therapeutic target;novel;novel therapeutics;oxidation;Pathologic;Pathway interactions;Patients;Permeability;Pharmaceutical Preparations;pharmacologic;Phenocopy;Phenotype;Phosphorylation;Physiological;Plasma Proteins;Play;Polymerase;Post-Translational Protein Processing;prevent;Production;Proteins;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Publishing;Pulmonary Edema;Pulmonary Inflammation;Reactive Oxygen Species;Regulation;Reporting;Reproducibility;rho;Role;Sepsis;Signal Pathway;Signal Transduction;Site-Directed Mutagenesis;small molecule;small molecule inhibitor;Stroke;Structure of parenchyma of lung;Testing;Therapeutic;therapeutic evaluation;therapeutic target;Tissues;TNF gene;tool;Vascular Permeabilities;Work

PROJECT_TITLE: Molecular mechanisms relating Poldip2 to endothelial permeability

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: Newark

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Tumors obtain most of their nutritional support for growth from normal tissues of the body through the circulating blood supply, yet what these nutrients are is not clear. Recent evidence suggests that nutrient scavenging pathways of normal tissues in the body contribute nutritional support for tumors, but this is also poorly understood. We propose to define tumor cell metabolism in action, identify nutrients provided by the body that are critical for the growth of lung cancers, and to determine their role in tumor growth and anticancer immune responses as a novel approach to the eradication of these deadly cancers.

PI_NAMEs: RABINOWITZ, JOSHUA D;WHITE, EILEEN P. (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Allografting;anti-cancer;Antineoplastic Agents;Autoimmunity;Autophagocytosis;base;Body Weight decreased;cancer cell;cancer diagnosis;cancer infiltrating T cells;cancer therapy;Carbon;Carcinoma;CCL2 gene;cell type;Cells;chemokine;Citric Acid Cycle;Clinical;Coupled;Defect;design;DNA Replication Proofreading;Energy Metabolism;fasting glucose;Fibroblasts;fighting;fluorodeoxyglucose positron emission tomography;Folic Acid Antagonists;Genetically Engineered Mouse;glucose metabolism;Glycolysis;Growth;Immune;immune checkpoint blockade;Immune response;Immunotherapy;Impairment;improved;in vivo;inhibition of autophagy;inhibitor;Isotopes;Knock-out;Knowledge;knowledge of results;Label;Learning;leukemia treatment;Light;macromolecule;Macrophage;Malignant neoplasm of lung;Malignant Neoplasms;mass spectrometric imaging;Mass Spectrum Analysis;Measurement;Measures;Metabolic;Metabolism;Methods;Methotrexate;mouse genetics;mouse model;Mus;neoplastic cell;next generation;Normal tissue morphology;novel strategies;Nucleic Acids;Nucleosides;nucleotide metabolism;Nucleotides;Nutrient;Nutritional Support;Oxidative Phosphorylation;Pain;Pathway interactions;Pemetrexed;Positron-Emission Tomography;Predisposition;Process;Purines;Recycling;Resolution;response;Role;Route;Slice;Sorting;Specificity;Supplementation;T-Lymphocyte;Time;Tissues;tool;transcriptomics;Translating;tumor;tumor growth;Tumor Immunity;tumor metabolism;tumor microenvironment;Vascular blood supply

PROJECT_TITLE: Tumor cell metabolism in action

STUDY_SECTION: CCB

STUDY_SECTION_NAME: Cancer Cell Biology Study Section[CCB]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Heart Disease;Hematology;Neurosciences;Prevention;Stroke

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative Embolic stroke of undetermined source may be due to a blood clot arising from the left atrium in susceptible patients. The optimal method to identify these susceptible patients – those with poor blood flow in the atrium or “atrial cardiopathy” – is unknown. This study will assess markers of atrial cardiopathy, including a novel MRI method that noninvasively assesses blood flow in the atrium, in various groups and will assess their predictive value for recurrent stroke in patients with embolic stroke of undetermined source.

PI_NAMEs: COLLINS, JEREMY DOUGLAS;GOLDBERGER, JEFFREY J (contact);MARKL, MICHAEL ;PRABHAKARAN, SHYAM ;ROMANO, JOSE G

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: 4D MRI;Adipose tissue;age related;Anatomy;Anticoagulants;Anticoagulation;Appearance;Assessment tool;Atrial Fibrillation;auricular appendage;Biological Markers;biomarker selection;Blood coagulation;Blood flow;brain magnetic resonance imaging;Brain natriuretic peptide;Cardiac;Cause of Death;Characteristics;Classification;Clinical;clinical decision-making;cryptogenic stroke;Detection;Development;Diagnosis;Diagnostic;diagnostic value;disability;Disease;Echocardiography;EKG P Wave;Electrocardiogram;embolic stroke;Evaluation;experience;follow-up;Goals;Guidelines;Heart;Heart Atrium;heart imaging;imager;Impairment;implantable device;improved;Individual;Institution;Ischemic Stroke;Left atrial structure;Link;Logistic Regressions;Magnetic Resonance Imaging;Methods;Monitor;Morphology;N-terminal;Neurologist;novel;Patients;Performance;Population;Positioning Attribute;Predictive Factor;predictive marker;Predictive Value;Predisposition;prevent;primary endpoint;Primary Prevention;Prospective Studies;Recurrence;Regression Analysis;Research;Risk;Risk Assessment;risk stratification;ROC Curve;secondary outcome;Secondary Prevention;Shapes;smart watch;Source;statistics;Stroke;stroke outcome;Stroke prevention;stroke risk;Thromboembolism;Thrombus;Time;tool;Transesophageal Echocardiography;Troponin;Uncertainty;Work

PROJECT_TITLE: Cardiac Imaging of Neuro-Embolic Mechanisms in Atriopathies causing Stroke (CINEMAS)

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Emergency Care;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Primary Health Care;Suicide;Suicide Prevention

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative Suicide is a leading cause of death among adolescents in the United States and improving access to high- quality just-in-time suicide interventions to reduce risk has important public health implications. Integrating such interventions into routinely accessed settings, such as pediatric primary care, holds promise; however, many clinicians in these settings fail to adequately screen or intervene in youth suicidal thoughts and behaviors, representing a key barrier to reducing suicide. The proposed study takes a user centered design approach to adapt and implement a brief, just-in-time suicide intervention to enhance adoption, implementation, and effectiveness of suicide intervention services in routinely accessed pediatric primary care settings to reduce youth suicide.

PI_NAMEs: DANZO, SARAH  (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: 18 year old;acceptability and feasibility;Accident and Emergency department;Acute;Address;Adolescent;adolescent suicide;Adopted;Adoption;Back;Behavior assessment;Caring;Cause of Death;Cessation of life;Childhood;Clinic;Cognitive;Collaborations;Consolidated Framework for Implementation Research;Crisis Intervention;Data;Depressed mood;design;Detection;Development;Discipline;Effectiveness;effectiveness/implementation trial;Emergency department visit;evidence base;experience;Family;Feasibility Studies;feasibility trial;Feeling hopeless;Feeling suicidal;flexibility;Future;Goals;Guidelines;Health system;Healthcare;High School Student;Home;implementation science;Improve Access;improved;Infrastructure;innovation;Intervention;intervention program;Intervention Trial;Interview;Investigation;Link;Literature;Managed Care;Medical Records;medical specialties;Mental Health;Mental Health Services;Methods;Modeling;mortality risk;Needs Assessment;older patient;Outcome;Outpatients;Parents;Pathway interactions;Patient Self-Report;Patients;pilot test;prevent;Prevention;prevention service;preventive intervention;Primary Care;primary care clinic;primary care clinician;primary care practice;primary care provider;primary care setting;Protocols documentation;prototype;Provider;Public Health;Quasi-experiment;recruit;reducing suicide;Research;Resources;retention rate;Risk Reduction;Safety;satisfaction;screening;screening and brief intervention;Self Efficacy;service gap;service intervention;Services;social determinants;Social isolation;Social support;stressor;suicidal adolescent;suicidal behavior;suicidal morbidity;Suicide;Suicide prevention;System;Testing;Time;Training;Training and Infrastructure;Trauma;treatment as usual;Triage;United States;uptake;usability;user centered design;Wait Time;Washington;Youth

PROJECT_TITLE: Adapting a brief suicide intervention for pediatric primary care: Enhancing uptake and impact

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative In this project, mechanistic basis of a new imaging agent for positron emission tomography (PET) of fibrosis associated with acute myocardial injuries is proposed. The agent, 18F-labeled glucaric acid, enables high resolution and sensitivity in diagnostic imaging of myocardial fibrogenesis. By detecting fibrosis early, this advancement is predicted to improve outcomes of medical therapy or surgical intervention in patients with myocardial diseases such as infraction, myocarditis, cardiomyopathy, amyloidosis, etc.

PI_NAMEs: AWASTHI, VIBHUDUTTA  (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Acids;Acute;Acute myocardial infarction;Address;Amyloidosis;antifibrotic treatment;attenuation;Binding;Biological Assay;Biology;Biopsy;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cell surface;Charge;Chemicals;Cicatrix;Clinical;Clinical Drug Development;clinical translation;Collagen;Consensus;Contracts;Coronary artery;coronary fibrosis;Data;Deposition;Detection;Diagnosis;Diagnostic Imaging;Diagnostic Procedure;Dose;dosimetry;Early Diagnosis;expectation;experimental study;Extracellular Matrix;fibrogenesis;Fibronectin Receptors;Fibronectins;Fibrosis;first-in-human;fluorodeoxyglucose;Glucaric Acid;Heart;Heart Arrest;Heart failure;Heart Injuries;Image;imaging agent;Imaging technology;improved outcome;in vivo;Individual;Infarction;Injury;Isoproterenol;ITGA5 gene;Knockout Mice;Label;Life Style;Ligands;Ligation;Magnetic Resonance Imaging;Maximum Tolerated Dose;Medical;Methods;Modeling;Molecular;Molecular Target;Monitor;Mus;Myocardial;myocardial biopsy;Myocardial Infarction;myocardial injury;Myocarditis;Myocardium;Necrosis;Non-Invasive Detection;novel;Operative Surgical Procedures;Outcome;Oxidants;Pathologic;Patients;Pharmaceutical Preparations;Phase;polymerization;Polymers;Positron-Emission Tomography;Pre-Clinical Model;prevent;Production;Proteins;Publishing;Quality Control;Radioactive;Radiometry;radiotracer;rapid technique;Regression Analysis;Relaxation;Reporting;Research;Residual state;Resolution;response;Sampling Errors;scaffold;Secondary to;Site;Site-Directed Mutagenesis;Structure;Surface;Surface Plasmon Resonance;Techniques;Time;Tissues;Toxic effect;Toxicology;uptake

PROJECT_TITLE: Mechanism of F-18-fluorodeoxyglucarate accrual in myocardial injury

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Childhood Obesity;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Disease;Obesity;Pediatric;Prevention

ORG_CITY: LA JOLLA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Nonalcoholic fatty liver disease (NAFLD) is a growing health concern that affects nearly 10% of all children and one in four children with obesity. The proposed research aims to validate the use of quantitative ultrasound (QUS) as a diagnostic tool for children at risk of NAFLD. By providing a better, safer, and more accessible method for diagnosing NAFLD in children, this study has the potential to transform clinical practices and contribute to public health initiatives focused on equitable healthcare for all children.

PI_NAMEs: SCHWIMMER, JEFFREY BARNETT;SIRLIN, CLAUDE B (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Address;Adult;Affect;Age;aged;American;Benchmarking;Cessation of life;Child;Child Health;Cirrhosis;Classification;Clinical;clinical practice;Clinical Practice Guideline;Clinical Research;Data;density;Diagnosis;diagnosis standard;Diagnostic;diagnostic tool;Early Diagnosis;Equitable healthcare;Fatty acid glycerol esters;Fatty Liver;Goals;Guidelines;Health;Hepatocyte;Histology;Image;improved;improved outcome;innovation;Liver;Magnetic Resonance Imaging;Measures;Methods;Modeling;Monitor;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Overweight;pediatric non-alcoholic fatty liver disease;Plasma;point of care;Predisposition;premature;prevent;Protons;Public Health;quantitative ultrasound;Radiology Specialty;Recommendation;Reference Standards;repository;Reproducibility;Research;Risk;screening guidelines;socioeconomics;Specialist;success;System;Technology;Testing;Therapeutic;tool;Translating;ultrasound;Vendor

PROJECT_TITLE: Quantitative Ultrasound To Diagnose Nonalcoholic Fatty Liver Disease in Children.

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: American Indian or Alaska Native;Biotechnology;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Kidney Disease;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE This project will use genomics and multi-omics to address important questions related to ancestry enriched genomic regions associated with clinical disease in Hispanics/Latinos, a minority population at risk of cardiometabolic diseases. Findings may have public health and clinical care implications.

PI_NAMEs: FRANCESCHINI, NORA  (contact);SOFER, TAMAR

PROGRAM_OFFICER_NAME: MORALES, JOANNELLA

PROJECT_TERMS: Address;Admixture;admixture mapping;African;African ancestry;Amino Acids;APOL1 gene;Biological Process;Biological Products;Biology;burden of chronic illness;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;Chromosomes;Chronic Kidney Failure;Clinical;clinical biomarkers;clinical care;Clinical Data;clinical phenotype;clinical translation;clinically relevant;cohort;Complex;Data;Diabetes Mellitus;Diagnosis;Disease;Disease susceptibility;disorder risk;Environmental Exposure;ethnic minority;European;fatty liver disease;Frequencies;Gene Frequency;Genes;Genetic;genetic association;Genetic Risk;genetic variant;Genome;genome wide association study;genome-wide;genomic data;Genomic Segment;Genomics;Genotype;Goals;Health;Healthcare;Hispanic Community Health Study/Study of Latinos;Hispanic Populations;human disease;improved;Individual;Inflammatory;Inherited;insight;Kidney;Kidney Diseases;Knowledge;Latino Population;Lipids;Maps;Measures;Mendelian randomization;Metabolic;Metabolic Diseases;Metabolism;metabolomics;Minority Groups;Molecular;mortality;multi-ethnic;Multiomic Data;multiple omics;National Human Genome Research Institute;Native American Ancestry;Native Americans;novel strategies;Obesity;Participant;Pathway interactions;personalized medicine;Physiological;Population;population based;Populations at Risk;Process;programs;protein biomarkers;Proteins;Proteomics;Public Health;racial minority;rare variant;Research;Signal Transduction;Single Nucleotide Polymorphism;social culture;Source;Strategic vision;Susceptibility Gene;Testing;trait;Trans-Omics for Precision Medicine;transcriptome sequencing;transcriptomics;Variant;Whole Blood

PROJECT_TITLE: Multi-omics study of ancestry enriched associations in Hispanics/Latinos

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative We have identified the Hippo pathway regulator KIBRA as a novel mediator of podocyte injury. The proposed research will define upstream regulators of KIBRA, delineate a non-canonical KIBRA-TEAD signaling axis, and test novel potential therapeutic strategies for podocyte injury.

PI_NAMEs: MELIAMBRO, KRISTIN  (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Actins;Adhesions;Agonist;Biochemical;Biomechanics;Biophysics;Biopsy;Brain;candidate identification;Cells;Chronic;clinically relevant;Cytoplasm;Cytoskeleton;Data;Development;diabetic;Diabetic Nephropathy;Disease;disease model;Disease Progression;Down-Regulation;Drug Kinetics;Event;Family;Focal Adhesions;Focal and Segmental Glomerulosclerosis;Gene Expression;Genes;glomerular basement membrane;Goals;Human;Hyperglycemia;Impairment;In Vitro;in vitro Model;in vivo;Individual;inhibitor;inhibitor therapy;Injury;Kidney;kinase inhibitor;Mediating;Mediator;MicroRNAs;Modeling;mouse model;Mus;novel;novel therapeutic intervention;Pathway interactions;Patients;pharmacologic;Phosphotransferases;podocyte;Protein Inhibition;Proteins;Regulation;Renal glomerular disease;Repression;Research;Risk;Role;Scaffolding Protein;Signal Pathway;Signal Transduction;Signaling Protein;SOX4 gene;targeted treatment;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;therapeutic target;transcription factor;Transcriptional Regulation;transcriptome sequencing;Treatment Efficacy;treatment strategy;Up-Regulation;Validation;Work

PROJECT_TITLE: KIBRA-induced biomechanical changes and therapeutic targeting in podocytes

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Genetics;Heart Disease;Hematology;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE Clonal hematopoiesis of indeterminate potential (CHIP) is a common, aging-related condition in which cells undergo somatic mutations that lead to overgrowth (“clones”) of a genetically distinct subpopulation of blood cells. This project will lead to improved insight into genetic and environmental risk factors for CHIP and the role of CHIP as a risk factor for various aging-related chronic diseases including heart failure.

PI_NAMEs: REINER, ALEXANDER P (contact);WHITSEL, ERIC A.

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Address;adjudication;Affect;age related;aging related;Anemia;Atherosclerosis;Behavioral;biobank;Biological Assay;Blood Cells;Blood specimen;Bone Marrow;Cardiovascular Diseases;cardiovascular disorder risk;Cells;Chronic;Chronic Disease;Clinical;Clonal Expansion;cognitive performance;cohort;comorbidity;cost effective;Data;Data Set;Disease;Disease Outcome;DNMT3a;driver mutation;efficacious treatment;EFRAC;Enrollment;Environmental Risk Factor;Epidemiology;follow-up;frailty;Funding;Future;Genes;Genetic;Genetic Anticipation;genetic risk factor;Growth;Heart failure;heart failure with reduced ejection fraction;Hematologic Neoplasms;Hematopoiesis;Hematopoietic stem cells;Heritability;improved;in silico;Individual;Inflammation;Inflammatory;insight;Life;Life Style;longitudinal design;Magnetic Resonance Imaging;Measurement;Measures;Mediation;middle age;Modification;monoclonal antibody LL2;Morbidity - disease rate;mortality;multi-ethnic;multiple omics;Mutate;Mutation;Myocardial Ischemia;next generation sequencing;non-genetic;novel;Obesity;older adult;older women;Outcome;Participant;peripheral blood;Phenotype;phenotypic data;Physical activity;Physical Function;Physical Performance;population based;Postmenopause;preservation;Prevalence;Preventive;Prognosis;programs;prospective;Resources;Risk;Risk Factors;risk stratification;Role;Sampling;Signal Transduction;Somatic Mutation;Syndrome;System;targeted sequencing;therapeutic target;Time;Trans-Omics for Precision Medicine;Validation;Woman;Women's Health

PROJECT_TITLE: Clonal Hematopoiesis in the Women's Health Initiative


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Social Determinants of Health

ORG_CITY: INDIANAPOLIS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Care planning is a key component of patient-centered care that supports patients in identifying and communicating their preferences for medical care and prepares them for both advance and in-the-moment decisions. However, confusion about what is involved in the care planning process and how to measure its effect on patient care has made it difficult to implement and evaluate, necessitating unprecedented basic science to move the field forward. This study uses implementation science and human factors engineering to: map the complexity of care planning through the experiences of diverse key informants (e.g., patients, caregivers, healthcare professionals, community leaders, legal/policy experts); Identify patient/caregiver centered and implementation outcomes; and define future care planning policy, research, and implementation.

PI_NAMEs: HICKMAN, SUSAN E (contact);SUDORE, REBECCA L

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: acute care;Address;Advance Care Planning;advanced directive;Basic Science;care outcomes;Caregivers;Caring;Chaplain;Characteristics;Chronic Disease;Clinical;Communication;Communities;community setting;Complex;Confusion;Consensus;Consolidated Framework for Implementation Research;Cultural Backgrounds;Decision Making;Dementia;Disparity;disparity reduction;Distress;Documentation;end of life;Engineering;ethnic diversity;Evaluation;Event;Evolution;experience;Faith;Focus Groups;follow-up;Future;Goals;health care availability;health care disparity;Health Professional;Health system;Heterogeneity;hospice environment;Human;implementation determinants;implementation outcomes;implementation process;implementation science;improved;informant;innovation;Inpatients;Intervention;Interview;Investments;Lawyers;Legal;Life;Life Cycle Stages;Long-Term Care;Maps;Measurement;Measures;Medical;Methodology;Methods;Modeling;Nurses;Nursing Homes;Outcome;Outcome Measure;Outpatients;Patient Care;patient population;Patient Self-Determination Act;Patient-Centered Care;Patient-Focused Outcomes;Patients;Persons;Policies;Population;preference;Procedures;Process;Readiness;Reduce health disparities;Research;Resources;Resuscitation;Rural;Sampling;satisfaction;Structural Racism;Surveys;United States Centers for Medicare and Medicaid Services;United States National Institutes of Health;Update;uptake

PROJECT_TITLE: Mapping the Complex Processes and Outcomes of Care Planning

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_CITY: Columbus

ORG_DEPT: NEUROLOGY

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative: Acute retinal ganglion cell (RGC) and optic nerve injury due to trauma, autoimmune inflammation, and ischemia reperfusion results in permanent disability due to eventual neuronal death. Arginase positive monocytes have long been associated with initiating neuroinflammation resolution and neuroprotective signaling to promote neuron recovery after acute injury. This proposal will determine the mechanisms in which arginase positive monocytes are polarized, how they interact with other inflammatory cells, and their role to promote survival and recovery of RGCs after injury.

PI_NAMEs: SAS, ANDREW ROBERT (contact)

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: Acute;Animal Model;arginase;autoimmune inflammation;Automobile Driving;Axon;axon regeneration;Blindness;Bone Marrow;candidate identification;CD14 gene;cell injury;Cell Wall;Cells;Central Nervous System;Circulation;Coculture Techniques;Crush Injury;cytokine;Cytoprotection;Development;Dimensions;Environment;experimental study;Eye;Eye diseases;Eye Injuries;Galectin 1;Glaucoma;glial activation;Goals;Growth Factor;Human;humanized mouse;Immune;Immunological Models;immunoregulation;Immunotherapy;Impairment;improved;In Situ;In Vitro;in vivo regeneration;Individual;Infiltration;Inflammation;Inflammatory;inflammatory milieu;Inflammatory Response;Injections;Injury;Innate Immune Response;Ischemia;Knock-out;Lifelong disability;mannose receptor;Mediating;Metabolic;Metalloproteases;Microglia;monocyte;Multiple Trauma;Mus;Myeloid Cells;Natural regeneration;Nerve Crush;Nerve Regeneration;Neurites;Neuroglia;neuroinflammation;neurological recovery;neuron loss;Neuronal Injury;Neurons;neuroprotection;neurotoxic;neutrophil;Neutrophil Infiltration;novel;Optic Nerve;optic nerve disorder;Optic Nerve Injuries;Outcome Study;Phagocytosis;Phenotype;Population;prevent;Production;Property;Proteins;Proteomics;Reactive Oxygen Species;Recombinants;Recovery;recruit;regenerative;repaired;Reperfusion Therapy;Resolution;response;Retina;Retinal Ganglion Cells;retinal stimulation;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;Sterility;Study models;Time;Transforming Growth Factor beta;Transforming Growth Factors;Translating;Trauma;Traumatic injury;Umbilical cord structure;Wild Type Mouse;Work;Zymosan

PROJECT_TITLE: Arginase positive monocyte mediated RGC neuroprotection after traumatic optic neuropathy

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Clinical Research;Genetics;Infectious Diseases;Malaria;Orphan Drug;Pediatric;Prevention;Rare Diseases;Vector-Borne Diseases

PHR: PROJECT NARRATIVE With repeated Plasmodium infections, children eventually gain the ability to tolerate Plasmodium parasitemia without developing symptoms. However, preventing malaria with effective chemoprevention may delay the development of this clinical immunity, such that children are at increased risk of more severe disease following cessation. In this proposal, we will evaluate correlates and mechanisms of clinical immunity, and specifically determine the effects of repeated Plasmodium infection and chemoprevention on Plasmodium-specific CD4+ T cell dynamics using samples collected from pediatric cohorts and mouse models.

PI_NAMEs: HAQUE, ASHRAFUL ;JAGANNATHAN, PRASANNA  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: 2 year old;4 year old;5 year old;Adaptive Immune System;Anti-malarials;Antibodies;Antibody Response;Antigens;Artemisinins;ATAC-seq;Binding;Birth;CD4 Positive T Lymphocytes;Cells;Cellular biology;Chemoprevention;Child;Childhood;Clinical;clinical development;clinical phenotype;Clinical Trials;Clonal Expansion;cohort;Collecting Cell;Complement;Data;Development;Disease;Enrollment;Epigenetic Process;epigenomics;Event;Exhibits;experimental study;field study;Foundations;Genes;Genetic;Genetic Transcription;genomic locus;Hour;Human;Immune response;Immunity;Impairment;Infant;Infection;Infection prevention;innovation;insight;international center;Kinetics;Liver;long term memory;Maintenance;Malaria;malaria infection;Mediating;Mediator;Memory;memory CD4 T lymphocyte;Modeling;mouse model;multiple omics;Mus;Organ;Other Genetics;Outcome;Parasitemia;Parasites;pathogen;Pathogenicity;Pediatric cohort;peripheral blood;Persons;Phenotype;Placebos;Plasmodium;Play;Population;Population Dynamics;prevent;Prevention;Probability;Proteomics;Randomized;Research;response;Risk;Role;Sampling;Severity of illness;single cell sequencing;Spleen;Structure of germinal center of lymph node;Supporting Cell;Symptoms;System;T cell differentiation;T cell receptor repertoire sequencing;T cell response;T-Lymphocyte;T-Lymphocyte Subsets;Testing;therapeutic development;Time;time use;Tissues;transcriptomics

PROJECT_TITLE: Deciphering mechanisms of CD4+ T cell-dependent clinical immunity to repeated Plasmodium infections

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Food Allergies

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Project Narrative Eosinophilic esophagitis (EoE) is an emerging form of allergic inflammation that exerts a significant clinical and financial burden worldwide. Here, we will define the impact of EoE inflammation on mitochondrial biology as well as the functional significance and clinical relevance of mitochondria in EoE. These studies have great potential to advance our understanding of EoE pathobiology and improve clinical care of EoE patients.

PI_NAMEs: WHELAN, KELLY A (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: 3-Dimensional;Allergic inflammation;Biogenesis;Biological Markers;Biology;Biopsy;Calcium;Cells;Chronic;Clinical;clinical care;clinically relevant;clinically significant;cohort;Data;Diagnosis;Disease;Endoscopy;Eosinophilic Esophagitis;Epithelial Cells;Epithelium;Esophagus;Evaluation;exosome;FDA approved;Financial Hardship;food allergen;Genetic;Human;Immune;improved;In Vitro;in vivo;Inflammasome;Inflammation;inflammatory milieu;Interleukin-13;keratinocyte;Mediating;Mediator;Membrane Potentials;Mitochondria;Mitochondrial DNA;mitochondrial genome;mitochondrial membrane;Modeling;Molecular;Monitor;Monoclonal Antibodies;Morbidity - disease rate;mtTF1 transcription factor;Mus;novel;novel marker;Nuclear;Nuclear Translocation;Organoids;Pathogenesis;Pathway interactions;Patients;Pattern;Phosphorylation;pleiotropism;response;Risk;Role;Serum;Signal Transduction;Squamous Differentiation;Squamous Epithelium;STAT3 gene;STAT6 gene;Stimulator of Interferon Genes;Testing;Time;Tissues;Upper digestive tract structure

PROJECT_TITLE: Mitochondria in eosinophilic esophagitis pathogenesis

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


NIH_SPENDING_CATS: Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_DEPT: NEUROSCIENCES

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Project Narrative / Relevance The NMDA receptor (NMDAR) is a key regulator of pain plasticity, yet we lack effective therapies for targeting NMDAR contribution to debilitating chronic pain resulting from disease conditions such as spinal cord injury. This project will explore a novel mechanism that modulates NMDAR function through extracellular direct protein- protein interaction with the EphB2 receptor tyrosine kinase. The proposed studies will: (1) test the hypothesis that extracellular phosphorylation of EphB2 controls NMDAR localization and function at excitatory synapses in pain neural circuitry, (2) examine the molecular mechanisms that govern these events, and (3) determine the impact of this mechanism on neuropathic pain in an animal model of spinal cord injury.

PI_NAMEs: COVARRUBIAS, MANUEL L;DALVA, MATTHEW B;LEPORE, ANGELO C (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Affect;allodynia;Amino Acids;Animal Model;Behavior;Biology;Cells;Cervical;Cervical spinal cord injury;Charge;Chemosensitization;Chronic;chronic pain;Complex;Data;Development;Disease;dorsal horn;effective therapy;EphB2 Receptor;Ephrin B Receptor;Event;Excitatory Synapse;extracellular;Genetic;Heterogeneity;Hyperalgesia;In Vitro;Individual;inducible gene expression;innovation;Intervention;Knock-in Mouse;Knock-out;Link;LoxP-flanked allele;Mediating;Modeling;Molecular;mouse model;Mus;N-Methyl-D-Aspartate Receptors;N-terminal;neural circuit;neuronal excitability;Neurons;neurotransmission;new therapeutic target;NMDA receptor A1;Nociception;novel;Opioid;Outcome;Pain;pain behavior;painful neuropathy;patch clamp;Pathologic;Persistent pain;pharmacologic;Phenotype;Phosphorylation;Phosphotransferases;Population;Posterior Horn Cells;Preparation;prevent;Property;protein protein interaction;Protein Tyrosine Kinase;psychologic;receptor;receptor function;Receptor Protein-Tyrosine Kinases;Refractory;Regulation;Rodent Model;Role;Sensory;side effect;Signal Transduction;Spinal Cord;Spinal Cord Contusions;Spinal cord injury;Surface;Synapses;synaptic function;Synaptic plasticity;Synaptic Receptors;Synaptic Transmission;targeted agent;targeted treatment;Testing;Therapeutic;transmission process;Work

PROJECT_TITLE: Exploring the EphB2-NMDA receptor interaction in spinal cord injury-induced neuropathic pain

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Liver Disease;Machine Learning and Artificial Intelligence;Organ Transplantation;Transplantation

ORG_CITY: NEW YORK

ORG_DEPT: SURGERY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Heart allocation uses six status groups that are undifferentiated and large, only coarsely reflecting each candidate’s risk of death on the waiting list, and exceptions which might be inequitably or inappropriately assigned have risen to comprise 30% of heart transplants. We will build a MESH (Model for End State Heart disease) score to prioritize transplants for the most urgently ill candidates, based on hemodynamic criteria in the context of cardiac pathology, end organ function, cause of heart failure, and eligibility for mechanical circulatory support therapies, correcting an arbitrary and coarse prioritization scheme and establishing a validated heart allocation scoring system that reduces the number of heart failure patients who die waiting for a heart. We will further incorporate MESH into a composite allocation score to balance priorities among increasing organ utilization, equalizing access to transplants, maintaining post-transplant survival, and decreasing waitlist deaths.

PI_NAMEs: GENTRY, SOMMER ELIZABETH (contact)

PROGRAM_OFFICER_NAME: SHANBHAG, SUJATA MADHUKAR

PROJECT_TERMS: Academy;Address;Algorithms;Blood;Cardiac;Categories;Cessation of life;Characteristics;Clinical;clinical care;clinical practice;combinatorial;Communities;Complex;Data;Data Set;Dedications;design;Diagnosis;Dimensions;disease model;Disparity;disparity reduction;Eligibility Determination;Ensure;Equilibrium;Equity;Ethnic Origin;Evolution;experience;Female;fitness;Functional disorder;Funding;geographic disparity;Geography;Government;Grant;Hand;Heart;Heart Diseases;Heart failure;Heart Transplantation;hemodynamics;Hospitalization;Hospitals;Incentives;Individual;Inequity;Kidney;Kidney Transplantation;left ventricular assist device;Liver;liver transplantation;Living Donors;Lung;Machine Learning;machine learning model;Measures;mechanical circulatory support;Medical;Medicine;Methods;model building;Modeling;mortality;mortality risk;Neurologic;Organ;organ procurement transplantation network;Organ Procurements;Organ Transplantation;Pathology;Patients;Performance;Policies;Policy Maker;post-transplant;preservation;Probability;programs;Pump;Race;Reporting;Research;Risk;risk stratification;Scheme;Scientist;Side;simulation;Solid;System;Thallium Myocardial Perfusion Imaging Stress Test;Time;Transplantation;Undifferentiated;Validation;ventricular assist device;Vulnerable Populations;Waiting Lists;Weight

PROJECT_TITLE: Optimizing the allocation of hearts from deceased donors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (90)]


NIH_SPENDING_CATS: Biotechnology;Nutrition;Obesity

ORG_CITY: AUGUSTA

ORG_DEPT: PHYSIOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

PHR: Project Narrative Obesity and its associated metabolic disorders remain major health problems worldwide. This study will address the importance of a novel protein post-translational modification in fat cell function, and will investigate how this modification regulates mitochondrial function and its implication in obesity. This research will also produce broadly applicable, basic biological insights into obesity.

PI_NAMEs: CHEN, WEIQIN  (contact)

PROGRAM_OFFICER_NAME: HAFT, CAROL R

PROJECT_TERMS: Adipocytes;Adipose tissue;Adult;Biochemical;Biological;Biological Process;Biology;Biotinylation;Body fat;Brown Fat;Cardiometabolic Disease;Cell Physiology;cellular targeting;CUL3 gene;Cullin Proteins;Data;diet-induced obesity;Endocrine Glands;energy balance;Energy Metabolism;Enzymes;Equilibrium;Family member;Fatty acid glycerol esters;feeding;Functional disorder;Genetic Transcription;Health;Heart failure;High Fat Diet;Homeostasis;Human;Impairment;improved;Inflammation;insight;Insulin Resistance;Knowledge;Ligase;Link;Lipodystrophy;Maintenance;Malignant Neoplasms;Mediating;Metabolic;Metabolic Diseases;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modification;Molecular;Monoamine Oxidase;Mus;novel;Obesity;obesity prevention;obesity treatment;Organism;Oxidation-Reduction;Pathologic;pharmacologic;Phenocopy;Play;Post-Translational Protein Processing;Process;Production;Proteins;Proteome;Proteomics;proteostasis;Research;Respiration;Role;scaffold;Signal Transduction;Site;Testing;Thermogenesis;Ubiquitin;ubiquitin ligase;Ubiquitin Like Proteins;ubiquitin-protein ligase;Ubiquitination

PROJECT_TITLE: Novel Posttranslational Modifications in Adipose Biology

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Heart Disease;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative This project is aimed to explore the mechanisms underlying increased risk of atherothrombosis driven by JAK2V617F clonal hematopoiesis and mechanism-based therapeutic approach.

PI_NAMEs: WANG, NAN  (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: Acceleration;Alleles;Anabolism;anakinra;Antibodies;Antioxidants;Aspirin;atherogenesis;Atherosclerosis;atherothrombosis;Blood Cells;Blood Platelets;cardiovascular disorder risk;cardiovascular disorder therapy;Cell Lineage;cell type;Cells;Clonal Expansion;Data;Development;Elderly;Erythrocytes;European;fitness;Generations;genetic variant;Goals;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Human;human induced pluripotent stem cells;Immunoglobulin G;Individual;Inflammasome;Inflammatory;Interleukin-1;Interleukin-1 beta;Lipid Peroxides;Macrophage;Mediating;Megakaryocytes;Modeling;monocyte;mouse model;Mus;mutant;Myeloid Cells;Myocardial Infarction;neutrophil;novel;Pathway interactions;Phagocytosis;Phospholipids;Population;Precision therapeutics;Process;Production;PTGS1 gene;PTGS2 gene;Risk;Risk Factors;Role;S100A8 gene;Signal Transduction;Somatic Mutation;Therapeutic;Thrombosis;thrombotic;Thromboxane A2;Thromboxane Production;Variant;Venous

PROJECT_TITLE: Atherothrombosis in JAK2V617F clonal hematopoiesis

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative The proposed study is highly significant and relevant to human health: (1) this study would provide better understanding of the FDXR biology and elucidate how FDXR mediates tumor suppression function via modulating p53/Mdm2/Mdm4; (2) this study will reveal a novel function of nuclear FDXR, which modulates redox signals in response to DNA damage response and repair (3) This study will characterize how FDXR activity is modulated via posttranslational modifications.

PI_NAMEs: CHEN, XINBIN  (contact)

PROGRAM_OFFICER_NAME: SALNIKOW, KONSTANTIN

PROJECT_TERMS: Acetylation;Acute;Binding;Biochemical;Biogenesis;Biological Process;Biology;Breast;Breast Cancer Cell;Cell Death;cell growth;Cell Nucleus;Cell Survival;Cells;Classification;Colorectal;Databases;desensitization;DNA Binding;DNA Binding Domain;DNA biosynthesis;DNA Damage;DNA Repair Enzymes;Electrons;Elements;enzyme activity;Enzymes;Epigenetic Process;erastin;Exons;Ferredoxin;Flavoproteins;Genes;Genetic;Health;heme a;Heme Iron;Human;Induction of Apoptosis;Iron;Knowledge;Large Intestine Carcinoma;life span;Lung;Lymphoma;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Mitochondria;Mitochondrial Proteins;Mus;Mutate;Mutation;NADP;Normal tissue morphology;novel;Nuclear;Nuclear Localization Signal;Oxidation-Reduction;Oxidative Stress;Oxidoreductase;Pathway interactions;patient derived xenograft model;Phosphorylation;Phosphotransferases;Pilot Projects;Post-Translational Protein Processing;Prognosis;promoter;Protein Isoforms;Proteins;Proteomics;pyruvate dehydrogenase;Reactive Oxygen Species;repaired;response;Ring Finger Domain;Role;sensor;Signal Transduction;Steroids;Stress;Structure;Sulfur;Testing;The Cancer Genome Atlas;Time;TP53 gene;Transcript;tumor;Tumor Suppression;Tumor Tissue;Zinc;Zinc Fingers

PROJECT_TITLE: The nuclear Ferredoxin reductase and its role in tumor suppression


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Neurosciences

PHR: Project Narrative In order to make sense of the barrage of sensory experience we encounter every day, our brains construct internal representations of the outside world. Here we will explore two such representations— a representation of self-movement, and a representation of food odor goals— in the simple and tractable brain of the fruit ﬂy, Drosophila melanogaster. These studies will show us how a simple neural circuit can construct abstract quantities from confusing sensory input.

PI_NAMEs: NAGEL, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TITLE: Multi-sensory representations for navigation in the central brain of Drosophila

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


PHR: In this study, we will test the function of USP16 in regulating expression of OXPHOS genes during the cardiac metabolic shift in mice.

PI_NAMEs: JIAO, KAI  (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: Address;Affect;anaerobic glycolysis;Animal Model;Biochemical;Biochemical Pathway;Bioenergetics;Bioinformatics;Birth;Cardiac;Cardiac Myocytes;cardiogenesis;Cardiomyopathies;Cell Respiration;cell type;ChIP-seq;clinical application;Complex;conditional knockout;Data;Defect;derepression;Development;DNA Binding Domain;Drosophila genus;Ectopic Expression;Elements;Epigenetic Process;epigenetic regulation;Equilibrium;experience;fetal;Fusion Protein Expression;Gene Expression;gene network;Generations;Genes;Genetic;Genetic Transcription;Goals;Heart;heart defect;Histone H2A;histone modification;Histones;Human;Impairment;Knockout Mice;Knowledge;Label;Life;Link;Mammalian Cell;Mammals;Maps;Metabolic;Mitochondria;Molecular;Monoubiquitination;mouse model;mRNA sequencing;Mus;mutant;Mutant Strains Mice;Myocardial;Myocardium;Neonatal;novel;Nuclear;nuclear respiratory factor;oxidation;Oxidative Phosphorylation;Oxygen;Pathway interactions;Patients;Perinatal;Perinatal mortality demographics;Physiology;Population;Post-Translational Protein Processing;postnatal;Process;programs;promoter;Promoter Regions;recruit;Reporting;Research;RNA Polymerase II;Role;single-cell RNA sequencing;Site;Source;Testing;Transcription Coactivator;transcription factor;Translating;ubiquitin isopeptidase;ubiquitin ligase;Uterus;Workload;yeast two hybrid system

PROJECT_TITLE: Epigenetic regulation of the metabolic shift in mammalian perinatal hearts

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE Friendships or ‘peer relationships’ impact diverse aspects of human health, from mood to mortality, but the mechanisms supporting formation of these relationships are poorly understood. This project uses peer and mate relationships in a monogamous rodent — the prairie vole — to study the role of oxytocin in different types of relationships, and how affiliation and avoidance shape selectivity of behavior for familiar individuals.

PI_NAMEs: BEERY, ANNALIESE K. (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Acceleration;Affect;Aggressive behavior;antagonist;anti social;antisocial behavior;autism spectrum disorder;Behavior;Binding;Brain region;Buffers;Cardiovascular system;Characteristics;Complex;CRISPR interference;Discrimination;Exhibits;Familiarity;Family member;Foundations;Friends;Friendships;genetic manipulation;Goals;Health;Housing;Human;immune function;Impairment;Individual;Individual Differences;Infusion procedures;Knock-out;Laboratories;Lateral;Longevity;Maintenance;Measures;Mediating;Methods;Microtus;model organism;Moods;mortality;Motivation;neural;Neuropeptides;novel;Nucleus Accumbens;Oxytocin;Oxytocin Receptor;Pair Bond;peer;peer support;Personal Satisfaction;Play;prairie vole;preference;receptor;Receptor Signaling;Relationship-Building;reproductive;Research;Rodent;Role;Same-sex;Seasons;sex;Shapes;Signal Transduction;social;social attachment;Social Behavior;Social Environment;social factors;Social Interaction;social neuroscience;social relationships;social structure;Specificity;Stress;Stressful Event;Testing;Time;Translating;Williams Syndrome;Work

PROJECT_TITLE: Mechanisms supporting selective affiliation between peers

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE As there are currently no medical therapies to alter the onset or progression of osteoarthritis, this grant renewal will establish 4-aminobutyrate aminotransferase (Abat) as the key downstream target of DNA methyltransferase 3b (Dnmt3b) in regulating joint homeostasis. We will determine if suppressing Abat gene expression protects against osteoarthritis, synovial inflammation, and pain by targeting cartilage and/or synovial tissue in the setting of joint injury. Finally, we will evaluate siAbat targeted nanoparticle-based gene therapy as a potential treatment for osteoarthritis.

PI_NAMEs: O'KEEFE, REGIS J (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: 4-Aminobutyrate aminotransferase;Acceleration;Address;Affect;Aging;Anti-Inflammatory Agents;Arthralgia;Attenuated;Cartilage;Catabolism;Cells;Chondrocytes;Collagen Arthritis;Compensation;Cytoprotection;Data;Degenerative polyarthritis;Development;Disease;DNA analysis;DNA methylation profiling;DNMT3B gene;epigenetic regulation;Fibroblasts;Funding;gain of function;gamma-Aminobutyric Acid;Gene Deletion;Gene Delivery;Gene Expression;gene therapy;Genetic;genetic approach;Genetic Models;Grant;Homeostasis;Human;In Vitro;in vivo;Inflammatory;innovation;joint injury;Joints;Knee Injuries;Knowledge;ligament injury;loss of function;Macrophage;Mediating;Mediator;Medical;member;Meniscus structure of joint;Methodology;Methylation;Modeling;mouse model;Mus;Myeloid Cells;nanoparticle;nanoparticle delivery;novel;osteoarthritis pain;overexpression;Pain;Pain Measurement;Pathogenesis;Pathologic;Penetration;Peptides;Phenotype;Population;Pre-Clinical Model;prevent;Process;promoter;protective effect;Role;Sclerosis;Signal Transduction;small molecule inhibitor;Synovial Cell;Synovial Membrane;Synovitis;Therapeutic Effect;Therapeutic Intervention;therapeutic target;Tissues;transcriptome sequencing;transgene expression;translational approach;Up-Regulation;Vigabatrin

PROJECT_TITLE: Epigenetic Regulation in Cartilage Tissue

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-L (03)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Cancer

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Narratives The proposed research is relevant to public health because regulating HMGCS1, the first committed enzyme for the mevalonate pathway, is critical for the de novo synthesis of cholesterol and other non-steroid end products. This grant will investigate how mevalonate enzymes respond to cell growth signaling and sustain sterol metabolism in cancers, specifically focusing on the first enzyme of the pathway. This study will contribute to a fundamental understanding of sterol homeostasis in normal physiology and cancers.

PI_NAMEs: AN, HEESEON  (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: 3-hydroxy-3-methylglutaryl-coenzyme A;Acetyl Coenzyme A;Adult;aged;Amino Acids;anti-cancer;Antineoplastic Agents;Attention;Biochemical;Biological;Biological Assay;Blood;C-terminal;cancer cell;cell growth;Cell Line;Cell membrane;Cell Proliferation;Cells;Cholesterol;Clinic;Complex;CRISPR/Cas technology;Cytosol;Data;Endoplasmic Reticulum Degradation Pathway;environmental change;enzyme pathway;Enzymes;epidemiology study;Feedback;Gatekeeping;Genetic Transcription;Grant;Hour;In Vitro;Interruption;Intervention;isoprenoid;Lanosterol;Limes;Malignant Neoplasms;Membrane;membrane biogenesis;Metabolic;Metabolism;metabolomics;mevalonate;Mixed Function Oxygenases;Modeling;Molecular;mTOR inhibition;multicatalytic endopeptidase complex;Mus;neoplastic cell;novel;Nutrient;Nutrient availability;Nutrient Depletion;Oxidoreductase;Pathway interactions;pharmacologic;Physiological;Physiology;prenylation;Production;Proline;Proteins;Proteolysis;Proteomics;Public Health;reconstitution;Regulation;Regulatory Pathway;Reporting;Research;response;Role;Signal Transduction;Squalene;Starvation;sterol homeostasis;Sterols;Stimulus;Stress;System;Tail;therapeutic target;tool;Translation Process;Ubiquitin;ubiquitin-protein ligase;uptake;Xenograft Model

PROJECT_TITLE: Mechanism and Significance of HMG Co-A Synthase 1 Degradation

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: SYRACUSE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: Narrative Retinal vascular disruption during development and in adulthood is a major cause of blindness, yet the underlying mechanism remains largely unknown. We recently identified a T-box transcription factor, TBX3, as a novel regulator for this process. This application aims to determine how TBX3 functions to affect retinal angiogenesis.

PI_NAMEs: VICZIAN, ANDREA S (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Ablation;Adult;Affect;Amacrine Cells;angiogenesis;Arteries;Astrocytes;ATOH7 gene;Automobile Driving;Biology;Blindness;Blood Vessels;cell type;Cells;Cellular biology;conditional knockout;Coupled;Data;Databases;Defect;density;Development;Disease;Dopamine;dopaminergic differentiation;Dorsal;Embryo;Endothelial Cells;Enzymes;Event;Extracellular Matrix Proteins;Eye diseases;Familial exudative vitreoretinopathy;Future;Genes;Genetic;genetic manipulation;Genetic Transcription;Glaucoma;Gliosis;Goals;In Vitro;Knowledge;Metabolic;migration;Modeling;Molecular;Molecular Analysis;Movement;Mus;mutant;neovascular;neural;neurogenesis;Neuroglia;Neurons;neurovascular coupling;neurovascular unit;new therapeutic target;Newborn Infant;novel;Oral;Outcome;Pathway interactions;Patients;Phenotype;Play;postnatal;Process;Production;Proliferating;Publications;recruit;Regulation;Research;response;Retina;retina blood vessel structure;retinal angiogenesis;Retinal Diseases;Retinal Ganglion Cells;retinal neuron;retinal progenitor cell;Retinopathy of Prematurity;Role;SHH gene;Signal Transduction;smoothened signaling pathway;Structure;Technology;Testing;Therapeutic;transcription factor;transcriptomics;Tyrosine 3-Monooxygenase;Vascular Diseases;Vascularization;vessel regression;Work

PROJECT_TITLE: The role of Tbx3 in retinal angiogenesis and eye disease

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: Chicago

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Understanding how receptor kinases achieve allosteric regulation at the molecular level is of fundamental importance for disease biology and drug discovery. This project will tackle the structural basis and molecular mechanism of allosteric signaling in two photoreceptor kinases using advanced biophysical methods. Insights gained from these studies are expected to reveal the general principles of protein allostery, and thus lay the groundwork for developing optogenetic tools and new therapeutic strategies to treat human diseases.

PI_NAMEs: YANG, XIAOJING  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: absorption;Address;Agonist;Allosteric Regulation;Allosteric Site;antagonist;Architecture;Automobile Driving;Bilin;Biochemical;Biochemistry;Biological Assay;Biological Process;Biology;biophysical analysis;biophysical techniques;Cell Physiology;Cellular Metabolic Process;chromophore;Cryoelectron Microscopy;Crystallography;Data;Data Set;Detection;dimer;Disease;drug discovery;Engineering;Enzymes;Event;experience;Feasibility Studies;Foundations;Goals;Heterogeneity;Human;human disease;insight;Joints;Length;Ligand Binding;Ligands;Light;Link;Logic;loss of function;Maps;Mediating;Methods;migration;Modeling;Molecular;Molecular Conformation;Motion;Mutagenesis;mutant;Mutation;Nature;novel therapeutic intervention;novel therapeutics;operation;optogenetics;Organism;particle;pathogenic bacteria;Perception;Phosphorylation;Phosphotransferases;Photoreceptors;Population;Protein Dynamics;protein-histidine kinase;Proteins;Protomer;Reaction;receptor;Receptor Protein-Tyrosine Kinases;Research;Resolution;response;Role;Sampling;scaffold;sensor;Sensory;Signal Transduction;Signaling Protein;Spectrum Analysis;structural biology;Structure;System;tool;Vertebral column;Virulence

PROJECT_TITLE: Structures, light signaling and allostery mechanisms of photoreceptor kinases

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]