NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

PI_NAMEs: RITCHIE, CHRISTINE S (contact)

PROJECT_TERMS: Active Learning;Affect;African American;Alzheimer's Disease;Alzheimer's disease related dementia;Biological Markers;Black American;Black Populations;Black race;Boston;Capital;care seeking;Caregivers;Caring;caucasian American;Clinic;Clinical;Clinical Research;Cognition;cohort;Communication;Communities;community advisory board;community engaged research;community organizations;community partners;community partnership;Creativeness;Data;Dementia;Development;Diagnosis;Diagnostic;diagnostic biomarker;digital;digital tool;Disclosure;Disease Progression;Education;education research;Educational Materials;Elderly;Ethnic Origin;Faith;Fostering;Fright;Frontotemporal Lobar Degenerations;Gender Identity;Health Professional;high risk;Hispanic;Hispanic Populations;Housing;Image;imaging biomarker;improved;Institution;International;Knowledge;Liquid substance;Massachusetts;medical specialties;member;Memory Disorders;Minority Groups;Mission;Modality;Neighborhood Health Center;Neighborhoods;neuroimaging;next generation;Not Hispanic or Latino;older adult;Outcome;outreach;Participant;participant retention;Patients;Persons;pharmacologic;Population Heterogeneity;Populations at Risk;Primary Care;Race;recruit;Research;Research Methodology;Research Personnel;research study;Resources;retention rate;Risk;Risk Factors;Science;Scientist;social stigma;Spanish;tool;Training

PROJECT_TITLE: Outreach, Recruitment, and Education Core


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PI_NAMEs: ARNOLD, STEVEN E (contact)

PROJECT_TERMS: alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;biobank;Biological;Biological Assay;Biological Markers;biomarker development;Blood;Blood Banks;blood-based biomarker;candidate marker;Cerebrospinal Fluid;Clinical;Clinical Management;clinical translation;Cognitive;cohort;Collaborations;Communities;Data;Data Analyses;data integration;Data Set;Detection;Development;Diagnosis;Diagnostic;Disease;disease heterogeneity;DLG4 gene;Education;Eligibility Determination;Evaluation;Exclusion;Experimental Designs;Faculty;Functional disorder;Goals;Health Professional;Image;Individual;Inflammatory;Institution;interest;International;Laboratories;Laboratory Scientists;Liquid substance;Marketing;Massachusetts;Measures;Medical Research;Medicine;Mentorship;Metabolic;Nerve Degeneration;neuropathology;next generation;novel;novel marker;Participant;Pathology;Pathway interactions;Patients;Performance;personalized medicine;Persons;Plasma;Population;Population Heterogeneity;Prevention;Process;Prognosis;prognostic;programs;Proteins;Proteomics;Qualifying;recruit;Relationship-Building;Research;Research Personnel;Resources;Role;Sampling;Scientist;specific biomarkers;Specimen;Staging;student mentoring;Synapses;Syndrome;synuclein;tau Proteins;Technology;Therapeutic Research;tool;Training;translational scientist;Underrepresented Populations;Validation;vascular contributions;Work

PROJECT_TITLE: Biomarker Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-G (J1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: BLACKER, DEBORAH L. (contact)

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease related dementia;Animal Model;Area;Basic Science;Biomedical Research;Brain;career development;Clinic;Clinical;Clinical Research;Cognitive;cohort;Collaborations;college;Data;Dementia;Development Plans;digital phenotyping;disadvantaged background;Discipline;education research;Educational workshop;Engineering;Ensure;Environment;Epidemiologist;ethnic diversity;experience;Faculty;Fellowship;Fostering;Funding;Future;graduate student;Institution;interest;Investments;Joints;K-Series Research Career Programs;Leadership;Learning;lecturer;longitudinal analysis;Massachusetts;Medical;Medicine;Mentors;Mentorship;Methodology;Methods;Mission;multidisciplinary;multimodality;neuroimaging;Neurologist;neuropathology;novel;Pathway interactions;Play;Price;Program Effectiveness;programs;Psychiatrist;racial diversity;recruit;Research;Research Methodology;Research Personnel;Research Support;Resources;responsible research conduct;Role;Rotation;Science;Scientist;Series;Services;summer internship;symposium;three dimensional cell culture;Training;training opportunity;Training Programs;Translations;Underrepresented Populations;Work

PROJECT_TITLE: Research Education


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: DICKERSON, BRADFORD C (contact)

PROJECT_TERMS: Adoption;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;Amyloid;analytical method;analytical tool;Atrophic;Award;Biological Markers;career;Characteristics;Clinical;Clinical assessments;Clinical Data;clinical practice;Clinical Research;Clinical Trials;cohort;Collaborations;Communication;Communities;cost effective;Data;data acquisition;Data Analytics;Data Set;Dementia;Development;Diagnosis;Disease;Early Onset Alzheimer Disease;Education and Outreach;education research;Faculty;Free Will;frontotemporal degeneration;Funding;Goals;Grant;Human Resources;Image;imaging facilities;imaging modality;Individual;individual response;Industry;Inherited;innovation;inter-individual variation;interest;International;Intervention;Link;Liquid substance;Magnetic Resonance Imaging;Massachusetts;Measures;Methodology;Methods;Minority;Modality;Monitor;MRI Scans;Multicenter Studies;multidisciplinary;Multimodal Imaging;Nerve Degeneration;neuroimaging;neuroimaging marker;next generation;novel;operation;Outcome;Participant;Pathology;Patient Recruitments;Persons;Plasma;Play;Positron-Emission Tomography;Process;prognostication;programs;Protocols documentation;radiotracer;Reproducibility;Research;Research Personnel;research study;Resources;response;Role;Scanning;Science;Scientist;Subgroup;tau Proteins;Techniques;Tissues;Tracer;Training;translational scientist;Triplet Multiple Birth;United States National Institutes of Health;Validation;white matter;Work

PROJECT_TITLE: Neuroimaging Core


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: MADISON

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Recent studies have highlighted the link between fetal and early life exposures and the development of non- communicable diseases, such as cardiovascular disease and metabolic syndrome. This proposal aims at understanding how sterile inflammation at the maternal-fetal interface impacts the development of the fetal immune system. Developing a deeper understanding of the effects of maternal inflammation on fetal immune development will provide opportunities for the development of targeted therapeutics either in utero or once offspring are born.

PI_NAMEs: VAZQUEZ, JESSICA  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;Affect;Allergens;Asthma;Biopsy;Cardiovascular Diseases;Cells;chemokine;Child;Chromatin;Coagulation Process;cytokine;Data;Data Analyses;Decidua;Development;Disease;early life exposure;Environment;Euthanasia;Exposure to;fetal;fetal blood;Fetal Development;Fetal Growth Retardation;Fetal health;Fetal Tissues;Fetus;Fibrin Tissue Adhesive;Fibrinogen;Flow Cytometry;Future;Gene Expression Profiling;Goals;Health;Histology;Histopathology;human model;Image;Immune;Immune response;Immune system;Immunofluorescence Immunologic;Immunologics;imprint;in utero;Infant;Infection;Infectious Agent;Inflammation;Inflammatory;inflammatory marker;Injections;Invaded;Irritable Bowel Syndrome;Link;Macaca mulatta;Maternal Health;Maternal-Fetal Exchange;Metabolic syndrome;microbiome;Modeling;Molecular;Mononuclear;mother nutrition;Necrosis;nonhuman primate;offspring;Pathogenesis;Pathology;Phenotype;Physiology;Placenta;Placental Infarction;Pliability;Positioning Attribute;Pre-Eclampsia;Predisposition;Pregnancy;Pregnancy Complications;pregnant;prevent;Process;Regulatory T-Lymphocyte;Research Personnel;Research Proposals;Saline;Second Pregnancy Trimester;single cell ATAC-seq;single-cell RNA sequencing;skills;Spiral Artery of the Endometrium;Sterility;Suspensions;targeted treatment;Testing;therapy development;Third Pregnancy Trimester;Thrombin;Tissues;Training;transcriptomics;trophoblast;Umbilical Cord Blood;Villous

PROJECT_TITLE: Sterile Inflammation at the Maternal-Fetal Interface and Fetal Immune Programming in a Non-Human Primate Model

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Despite the promise of immune checkpoint PD-1 blockade therapy in triple-negative breast cancer (TNBC), only a fraction of the patients can benefit from it in terms of clinical response. It is highly desired to develop an effective therapy for overcoming resistance to PD-1 blockade. Therefore, we propose to test the hypothesis that targeting CD5 on T and B cells will enhance the anticancer effects of PD-1 blockade by using TNBC patient-derived organoids and xenograft tumor model.

PI_NAMEs: ZHANG, CHUNYAN  (contact)

PROGRAM_OFFICER_NAME: CHRISTEN, JAYNE

PROJECT_TERMS: anti-cancer;anti-PD-1/PD-L1;anti-PD-L1 antibodies;anti-PD1 antibodies;anti-PD1 therapy;anti-tumor immune response;Antibodies;antitumor effect;Autologous;B-Lymphocytes;Binding;Breast Cancer Model;Breast Cancer Patient;cancer infiltrating T cells;Carnitine Palmitoyltransferase I;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cellular Metabolic Process;checkpoint inhibition;Clinical;Coculture Techniques;Data;Disease remission;effective therapy;effector T cell;exhaustion;Failure;fatty acid oxidation;Glycolysis;Glycolysis Inhibition;Human;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune system;Immunotherapy;improved;Infiltration;insight;Interferon Type II;Interleukin 6 Receptor;Interleukin-10;Interleukin-6;Ligation;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Metabolic;Metabolism;Modeling;mouse model;Mus;neoplasm immunotherapy;neoplastic cell;novel;novel strategies;novel therapeutic intervention;Organoids;Outcome;patient derived xenograft model;Patients;PD-1 blockade;Peripheral Blood Mononuclear Cell;Pilot Projects;polyoma middle tumor antigen;pre-clinical;Production;Prognosis;programmed cell death protein 1;Proliferating;reconstitution;Reporting;Resistance;response;Role;Sampling;Signal Transduction;Specimen;STAT3 gene;success;T-Cell Activation;T-Lymphocyte;Testing;therapy outcome;therapy resistant;transcription factor;treatment response;triple-negative invasive breast carcinoma;tumor;Tumor Immunity;tumor microenvironment;tumor xenograft;Tumor-infiltrating immune cells

PROJECT_TITLE: Developing a novel therapeutic strategy for overcoming resistance to PD-1 blockade in Triple-negative breast cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-A (J1)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Hematology;Pain Research;Pediatric;Prevention;Rare Diseases;Sickle Cell Disease

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: RELEVANCE TO PUBLIC HEALTH The knowledge to be gained from this investigation will establish whether chronic dehydration during steady- state conditions is predictive of morbidity and mortality in patients with sickle cell disease and has the potential to influence patient behavior and recommendations for care, such as at-home hydration monitoring to encourage fluid intake for the prevention of painful vaso-occlusive episodes.

PI_NAMEs: KARAFIN, MATTHEW S (contact);NOVELLI, ENRICO M

PROGRAM_OFFICER_NAME: ZOU, SHIMIAN

PROJECT_TERMS: Accident and Emergency department;Acute;adjudication;Adolescent;Adult;Adverse event;African ancestry;age difference;age related;American;Behavior;Biological Assay;Biological Markers;Black American;Blood capillaries;Blood Vessels;Caring;Cessation of life;Child;Chronic;Clinical;Clinical Research;cohort;cooperative study;Data;Data Collection;Dehydration;Development;Disease;Emergency department visit;Enrollment;Environment;epidemiology study;Erythrocytes;Event;Exclusion;experience;Exposure to;Fetal Hemoglobin;Finding of Mean Corpuscular Hemoglobin;follow-up;Functional disorder;Genetic;health knowledge;Hematopoietic stem cells;Hemoglobin;hemoglobin polymer;Hemolysis;Home;Hospitalization;hospitalization rates;Hydration status;hydroxyurea;Hypoxia;Impairment;improved;indexing;infancy;Infant;Intake;Investigation;Kidney Diseases;kidney dysfunction;Knowledge;Liquid substance;Measurement;Measures;Medical center;Microfluidics;Microscopy;Monitor;Morbidity - disease rate;mortality;Multicenter Studies;Mutate;Natural History;Observational epidemiology;Obstruction;Organ;Osmolalities;Osmosis;Outcome;Oxygen;Pain;Participant;Patients;Phenotype;Polydipsia;Population Sizes;Predisposition;Prevalence;prevent;Prevention;Production;programs;prospective;Prospective Studies;Public Health;Quality of life;Recommendation;recruit;Reporting;Risk;Role;secondary analysis;Serum;sex;Sickle Cell;Sickle Cell Anemia;Specific Gravity;Specimen;study population;Thirst;thirst regulation;Time;Universities;Urine;Whole Blood

PROJECT_TITLE: Chronic dehydration in sickle cell disease: An actionable biomarker to prevent vaso-occlusive episodes?

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-K (J1)]


NIH_SPENDING_CATS: Biotechnology;Immunization;Infectious Diseases;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Rare Diseases;Sexually Transmitted Infections;Vaccine Related

ORG_CITY: VICTORIA

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY OF VICTORIA

ORG_STATE: BC

ORG_ZIPCODE: V8P 5C2

PHR: PROJECT NARRATIVE  Syphilis affects millions of people worldwide, and its global rates are on the rise. We have developed a promising syphilis vaccine chimera that could help curtail the spread of this serious infection. In this proposal, we will study alternative formulations of the chimera vaccine candidate with the overall goals of increasing its protective efficacy against infection and generating a syphilis vaccine candidate that is ready for clinical studies.

PI_NAMEs: CAMERON, CAROLINE E (contact);GIACANI, LORENZO

PROGRAM_OFFICER_NAME: HILTKE, THOMAS J

PROJECT_TERMS: Adjuvant;Affect;Animal Model;Antigenic Variation;Antigens;Bacterial Adhesins;beta barrel;Biological Assay;Blood Vessels;Cardiovascular Manifestation;Cessation of life;Chimera organism;Chimeric Proteins;Clinical Research;clinical trial readiness;Collaborations;combat;congenital infection;Congenital Syphilis;cost;Cyclic GMP;Dementia;Development;Distant;efficacy testing;Engineering;Epitopes;Exhibits;experience;experimental study;Fetal Development;Formulation;Funding;Future Generations;Generations;global health;Goals;Hand;Immune;Immune Evasion;Immune response;Immunization;Immunize;immunogenicity;immunoreactivity;in vivo;Income;industry partner;Infection;Investigation;Investigational Drugs;Lead;lead candidate;low and middle-income countries;manufacture;manufacturing scale-up;Membrane;Membrane Proteins;Modeling;Molecular;Neurologic;novel;Organ;Oryctolagus cuniculus;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Persons;Phase;Positioning Attribute;preclinical study;Pregnancy;prevent;Process;Production;programs;protective efficacy;Protein Family;Proteins;Research;RNA vaccine;Running;safety assessment;scaffold;scale up;Sequence Homology;Serum;stability testing;stroke-like outcome;Subunit Vaccines;success;Surface;Syphilis;syphilis vaccine;Syphilitic chancre;Testing;Toxic effect;Toxicity Tests;transmission process;Treponema pallidum subspecies pallidum;United States;United States National Institutes of Health;Universities;vaccine candidate;vaccine delivery;Vaccines;Vesicle;Washington

PROJECT_TITLE: Development of a Chimeric Syphilis Vaccine Candidate to Combat Local, Disseminated and Congenital Syphilis Infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 KAR-M (J1)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Regenerative Medicine

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Regeneration of the distal lung following severe injury (e.g. influenza or COVID-19) is an imperfect process, and frequently leads to permanently altered lung structure and chronic reduction in gas exchange function highlighting the need for a better understanding of alveolar regenerative processes. This proposal investigates how distinct mesenchymal lineages in the lung contribute to lung regeneration through their plasticity and signaling with other cells in the regenerating alveolar niche. The work that will arise from this proposal will enhance our understanding of the role of mesenchymal cells in lung regeneration and identify mechanisms which can be harnessed in the future to develop new therapies for patients with chronic lung disease.

PI_NAMEs: JONES, DAKOTA L (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Advisory Committees;Alpha Cell;Alveolar;alveolar epithelium;alveolar homeostasis;Alveolus;Area;Beta Cell;Bioinformatics;Biological Assay;Biology;career;Cell Differentiation process;Cell division;Cell Lineage;Cell Physiology;Cell Proliferation;cell type;Cells;Cellular biology;Chronic;Chronic lung disease;Coculture Techniques;Communities;Confocal Microscopy;COVID-19;COVID-19 patient;Data;Development;Distal;Environment;Epigenetic Process;epigenomics;Epithelial Cells;Epithelium;epithelium regeneration;Equilibrium;Exhibits;Foundations;Future;Gases;Genetic Transcription;Genomics;Heterogeneity;Human;Influenza;influenza infection;injured;Injury;insight;Institution;International;Intervention;keratinization;Label;Lead;Lentivirus;Lung;Lung infections;lung injury;lung regeneration;Maintenance;Mediating;Mentors;Mesenchymal;Mesenchyme;Modeling;multiple omics;Mus;Natural regeneration;notch protein;NOTCH3 gene;novel;novel therapeutics;Organoids;Paracrine Communication;Pathologic;Pathology;Pathway interactions;Patients;Pennsylvania;Phase;Physiological;Population;Positioning Attribute;post-doctoral training;Process;progenitor;Proliferating;pulmonary function;receptor;Recovery;regeneration function;regenerative;Regenerative response;repaired;Research;Research Personnel;Resources;response;Role;severe injury;Signal Transduction;single cell genomics;single-cell RNA sequencing;skills;Sorting;stem cells;Structure;Testing;Therapeutic;Time;Training;transcriptomics;Transgenic Mice;Universities;Viral;Viral Respiratory Tract Infection;Virus Diseases;Work

PROJECT_TITLE: Mesenchymal cell plasticity and signaling in lung regeneration

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI (JA)]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Insects can be detrimental to human populations due to the transmission of a variety of diseases and agricultural destruction. Chemosensory systems are critical for the effectiveness of these insects; olfaction is particularly important for navigating through the environment and finding human hosts and food. This project is designed to understand the molecular mechanisms by which these systems operate and could lead to new methods of controlling these insects and their impact on humans.

PI_NAMEs: TALROSS, GAËLLE J.S. (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Address;Afferent Neurons;Agriculture;Animals;Antibodies;Behavior;Behavioral;Behavioral Assay;Biological Assay;Biological Process;catalyst;Characteristics;Codon Nucleotides;Complex;Cues;Data;design;Detection;Dimensions;Disease;Drosophila genus;Effectiveness;Electrophysiology (science);Environment;ethyl acetate;Event;Exhibits;experience;experimental study;Exposure to;fly;Food;Funding;Genes;Genetic;Genetic Transcription;Human;Immunoprecipitation;Insect Control;Insecta;insight;interdisciplinary approach;Investigation;Knowledge;Label;Lymph;Mass Spectrum Analysis;Mediator;Mentors;Methods;Modification;Molecular;mutant;Names;Nervous System;neurodevelopment;Neurologic Process;Neurons;Neurophysiology - biologic function;novel;Nucleotides;Odors;Olfactory Pathways;Olfactory Receptor Neurons;Open Reading Frames;Organ;Partner in relationship;Pattern;Peptides;Peripheral;Phase;Phenotype;Pheromone;Play;Population;Positioning Attribute;post-doctoral training;professor;Property;Regulation;Research Personnel;Research Proposals;response;ribosome profiling;Ribosomes;RNA;Role;Secure;Sensory;sensory system;skills;Smell Perception;Source;Specificity;Starvation;Surveys;synergism;System;Testing;Tissues;tool;Training;Transcript;transcription factor;Translations;transmission process;Universities;Untranslated RNA;Up-Regulation;virtual;Work

PROJECT_TITLE: A new dimension to the olfactory system: long non-coding (lnc)RNAs and a lncRNA-encoded micropeptide

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: HD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: Newark

ORG_DEPT: MISCELLANEOUS

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Premature infants can spend weeks in the neonatal intensive care unit (NICU), where they are exposed to damaging levels of noise and light. The proposed project will establish an animal model of NICU exposure that will allow researchers to investigate the impact of the NICU on sensory system development and learning.

PI_NAMEs: MOWERY, TODD M. (contact)

PROGRAM_OFFICER_NAME: SANTOS SCHMIDT, AUGUSTO FREDERICO

PROJECT_TERMS: Adolescence;Adolescent;Adult;Affect;Air;Anatomy;Animal Experimentation;Animal Model;Animal Testing;Animals;Auditory;Auditory area;Auditory Brainstem Responses;Auditory Physiology;Auditory Threshold;Behavior;behavior test;behavioral impairment;Birth;Brain;brain stem auditory evoked potentials;Caring;CDK6-associated protein p18;Cell Physiology;cellular development;Child;Childhood;Chronology;Clinical;clinical care;Clinical Treatment;Cognition;Color;Communities;critical period;Data;Decision Making;Development;discrimination task;Ear;Electrophysiology (science);Environment;Ethics;experience;experimental study;Exposure to;External auditory canal;Eye;Eyelid structure;Foundations;Frequencies;Gays;Gerbils;gray matter;Growth;Hearing;Hearing Tests;Histologic;Histology;Human;Impaired cognition;Impairment;in utero;In Vitro;infancy;Infant;insight;Jird;Language;Learning;Light;light intensity;longitudinal design;Longitudinal Studies;Mammals;Manuals;mature animal;Measurement;Measures;Modality;Neonatal Intensive Care Units;neonate;Neuropathy;Noise;noise exposure;Ocular Physiology;Performance;Peripheral;Physicians;Physiological;Physiology;postnatal;premature;Premature Birth;Premature Infant;Preparation;Process;Property;pup;receptor;Reporting;Research;Research Personnel;Retinal Diseases;Rodent Model;Sensory;sensory system;Slice;sound;Stimulus;Synapses;synaptic function;Systems Development;Testing;Validation;Vision;vision development;Visual;Visual Cortex;Visual evoked cortical potential;visual learning;visual threshold;Visuospatial;white matter;white matter injury;Whole-Cell Recordings;World Health Organization

PROJECT_TITLE: An Animal Model of Neonatal Intensive Care Unit Exposure to Light and Sound

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Patient Safety;Precision Medicine;Rare Diseases;Urologic Diseases

ORG_CITY: Los Angeles

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE  The proposed research is relevant to public health to develop assays for diagnosis, prognosis, and monitoring recurrence of patients with Upper Tract Urothelial Carcinoma (UTUC) in order to improve the overall survival benefit for these patients. There is urgent need for a novel personalized medicine approach, and this can be achieved by identifying and validating new DNA methylation biomarkers to identify a priori which patients will have favorable outcomes prior to any treatment taking place or monitor treatment responseand possible disease recurrence. The success of this proposal will minimize unnecessary chemotherapy administration for patients before surgery, reduce the associated patient morbidity/mortality, reduce delays to surgery, improve patient quality of life and reduce the overall health burden that is associated with receiving unnecessary chemotherapy. The mission of this proposal is to improve the overall clinical management for UTUC patients.

PI_NAMEs: DJALADAT, HOOMAN ;LIANG, GANGNING  (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Adjuvant Chemotherapy;Biological Assay;biomarker identification;biomarker panel;biomarker validation;Biopsy;Bladder;bladder transitional cell carcinoma;Carcinoma;chemotherapy;clinical decision-making;clinical efficacy;Clinical Management;contrast enhanced;Country;Cytology;Data;Detection;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic Factor;Disease;disease diagnosis;DNA Markers;DNA Methylation;Evaluation;Excision;Exhibits;Gene Expression Regulation;Goals;Health;high risk;Image Enhancement;improved;Incidence;intravesical;Investigation;Kidney;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Measures;methylation biomarker;methylation pattern;Mission;Modeling;Molecular;Monitor;Monitoring for Recurrence;Morbidity - disease rate;mortality;multidisciplinary;Muscle;Neoadjuvant Therapy;neoplastic cell;noninvasive diagnosis;novel;Operative Surgical Procedures;Outcome;Pathologic;Pathology;Patient Monitoring;Patient Selection;patient stratification;Patients;personalized medicine;Physicians;predictive tools;Predictive Value;Primary Neoplasm;Procedures;Prognosis;prognostic;Prognostic Factor;public database;Public Health;Quality of life;Rare Diseases;Recurrence;Recurrent disease;Research;Residual Neoplasm;risk stratification;Role;Sampling;Slide;specific biomarkers;Specificity;Specimen;Staging;standard care;standard of care;success;Survival Rate;Technology;Testing;Tissues;TNM;tool;Transitional Cell Carcinoma;treatment response;tumor;Tumor Tissue;Ureteroscopy;urinary;Urine;Urothelium;Visit

PROJECT_TITLE: Using DNA Methylation Markers for Diagnosis and Prognosis of Upper Tract Urothelial Carcinoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-1 (J2)]


ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: The proposed research is relevant to public health because identifying enhancers in vector insects is essential for better understanding the biology of these important disease vector species and for developing biotechnological applications for their control.

PI_NAMEs: HALFON, MARC S (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Address;Aedes;Anopheles gambiae;Biological;Biological Process;Biology;Biotechnology;cell type;Cells;Cessation of life;Computing Methodologies;Data;Databases;Development;Disease Vectors;DNA;Drosophila genome;Drosophila genus;Drosophila melanogaster;economic impact;Enhancers;Evaluation;experimental study;Gene Expression;gene regulatory network;Gene Structure;Genes;Genetic Enhancer Element;Genetic Transcription;Genome;Genome Components;genomic data;Genomics;Goals;improved;Insect Control;Insect Vectors;Insecta;Insecticide Resistance;interest;Life Cycle Stages;Mediating;Methods;Organism;Outcome;Partner in relationship;pathogen;Phenotype;Play;Public Health;rapid technique;Reporter Genes;Reproduction;Research;Role;single cell ATAC-seq;Source;success;Tissues;tool;Training;training data;transmission process;Validation;vector;vector control;vector mosquito;Work

PROJECT_TITLE: Generating better-targeted training data for computational enhancer discovery in vector insects

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Hematology;Infant Mortality;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: Project Narrative Babies who are born extremely premature commonly have low blood platelet counts and a high risk of bleeding, usually in the brain or lungs. For this reason, they commonly receive platelet transfusions to decrease the risk of bleeding, although a recent randomized trial suggested that premature babies who received less platelet transfusions had less bleeding and mortality than those transfused with a higher threshold. This has generated uncertainty among clinicians regarding the optimal platelet transfusion thresholds for extremely preterm infants, and this trial is specifically designed to address this uncertainty by evaluating if lower thresholds for platelet transfusions will lead to improved survival without bleeding among extremely preterm infants born at 23 to 26 weeks gestational age.

PI_NAMEs: DAS, ABHIK  (contact)

PROGRAM_OFFICER_NAME: FRANK, DANIEL J

PROJECT_TERMS: Address;Admission activity;Adult;Affect;Age;Area;Biometry;Birth;Blood;Blood Platelets;Brain;Child;Clinical;Clinical Trials;Collaborations;Communication;Companions;comparative effectiveness;Complex;cost;Data;Data Coordinating Center;data dissemination;design;electronic data capture system;Enrollment;Ensure;Europe;European;experience;Extravasation;extreme prematurity;flexibility;Gestational Age;Goals;Hematology;Hemorrhage;Hemostatic function;high risk;Human Resources;improved;improved outcome;Incidence;Infant;Infrastructure;Institution;Intracranial Hemorrhages;Knowledge;Leadership;Letters;Libraries;Life;Liquid substance;Lung;meetings;Monitor;Morbidity - disease rate;mortality;mortality risk;Multi-Institutional Clinical Trial;Multicenter Neonatal Research Network;Multicenter Trials;National Heart, Lung, and Blood Institute;National Institute of Child Health and Human Development;Neonatal;Neonatal Intensive Care Units;Neonatal Mortality;neonate;Network Infrastructure;Newborn Infant;operation;Patients;Planets;Platelet Count measurement;Platelet Transfusion;Population;postnatal period;Pregnancy;premature;Premature Infant;preterm newborn;prevent;Procedures;Process;Productivity;programs;prophylactic;Qualifying;Randomized;randomized trial;randomized, clinical trials;recruit;Reporting;Research;Research Design;Research Infrastructure;Resources;Risk;Role;Safety;secondary outcome;Site;Specific qualifier value;Statistical Data Interpretation;Structure;Surveys;System;Testing;Thrombocytopenia;Time;Training;Transfusion;trial comparing;trial design;trial planning;Uncertainty;vascular injury;web portal

PROJECT_TITLE: 2/2 Neonatal Platelet Transfusion Threshold Trial (NeoPlaTT)

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR (JA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Nutrition;Obesity;Prevention;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Food insecurity affects 13.5 million Americans and is associated with heart disease, diabetes, and poor diet quality. This project uses a community engaged approach to collaborate with food pantries to design, implement, and evaluate digital strategies to encourage pantry clients to choose healthier foods. The goal of the proposed work is to identify acceptable and effective community interventions to improve diet quality and promote cardiovascular health equity among a vulnerable US population.

PI_NAMEs: JIA, JENNY  (contact)

PROGRAM_OFFICER_NAME: ILIAS, MALIHA R

PROJECT_TERMS: acceptability and feasibility;Address;Adopted;Affect;American;Architecture;Award;Behavior Therapy;behavioral economics;Belief;Blood Pressure;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;career;Chicago;Client;Collaborations;Color;Communities;community engaged approach;community intervention;Consumption;cost;Data;Data Collection;Decision Making;design;Diabetes Mellitus;Diet;Dietary Practices;digital;Disparity;Effectiveness;effectiveness study;effectiveness trial;Evaluation;experience;Feedback;Focus Groups;Food;food environment;food insecurity;food security;Food Selections;Future;Goals;Health;Health Benefit;health equity;Health Food;Heart Diseases;high risk;Household;Hybrids;Hypertension;implementation barriers;implementation evaluation;implementation facilitators;implementation research;implementation science;improved;Individual;Inequity;innovation;Interdisciplinary Study;Interruption;Intervention;Intervention Studies;Interview;Knowledge;Label;Low income;Measures;Mentorship;Methods;Modeling;National Heart, Lung, and Blood Institute;new technology;nutrition;Nutrition Labeling;Nutritional;operation;Persons;Population;population health;prevent;prototype;repository;Research;Research Personnel;Research Priority;Resources;Restaurants;Risk Factors;Series;Site;social;social stigma;Strategic vision;System;Testing;therapy design;Time;Training;Training Programs;Training Support;Unhealthy Diet;uptake;Visit;Weight;Work

PROJECT_TITLE: Community-engaged Design and Implementation of a Behavioral Economics Food Choice Intervention in Food Pantries to Improve Cardiovascular Health

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (JA)]


ADMINISTERING_IC: DE

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Neurosciences;Pediatric

ORG_CITY: COLLEGE PARK

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because of the biological significance and contribution of neural crest and placode cells to the proper formation of human bodies, including the development of the peripheral nervous system like the trigeminal ganglion, bones and cartilage of the face, skin pigment cells, and parts of the heart. How these cells contribute to these diverse structures and generate these different cell types can help us comprehend what happens when development is impaired and human disease ensues. Thus, the proposed research is directly relevant to NIH’s mission to understand the fundamental processes controlling development and the use of that knowledge to improve overall human health and quality of life.

PI_NAMEs: TANEYHILL, LISA A (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Address;Affect;afferent nerve;Afferent Neurons;Appearance;Axon;Binding;Biological;Biological Models;bone;Bone Development;Brain;Cartilage;cartilage development;cell type;Cells;Cellular biology;Cellular Structures;Cephalic;Chick;Chick Embryo;Cleft lip with or without cleft palate;Congenital Abnormality;Cranial nerve diseases;Cranial Nerves;Craniofacial Abnormalities;craniofacial development;Critical Pathways;Data;Defect;design;Development;Disease;Embryo;Embryology;Esthesia;Etiology;Exhibits;experience;Face;Financial Hardship;Ganglia;Gene Expression;Goals;Head;Health;Health system;Healthcare Systems;Heart;holistic approach;Human;Human body;human disease;Impairment;improved;Infant Mortality;innovation;interdisciplinary approach;knock-down;Knowledge;Ligands;long bone;Maintenance;Mechanoreceptors;Mediating;Membrane;Mesenchyme;Mesoderm;Mission;Modality;Modeling;Molecular;Molecular Target;Nerve;nerve supply;Nerve Tissue;Neural Crest;Neural Crest Cell;neurodevelopment;Neuroglia;neuronal cell body;Neurons;neurotransmission;Nociceptors;novel therapeutics;Oral cavity;orofacial;Pain;Pathway interactions;Pattern;Peripheral Nervous System;Positioning Attribute;Process;programs;Provider;Public Health;Quality of life;receptor;receptor expression;repaired;Research;Role;Sensory;Signal Transduction;skeletal;Skin Pigmentation;somatosensory;Structure;Structure of trigeminal ganglion;System;Temperature;Therapeutic;Tissues;Touch sensation;transcriptome sequencing;transcriptomics;transmission process;Trigeminal nerve structure;Trigeminal System;United States National Institutes of Health;virtual;Work

PROJECT_TITLE: Trigeminal nerve-target tissue interactions during craniofacial development

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: DAVIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Significant disparities in cancer mortality persist among adolescents and young adults (AYAs) with Ewing sarcoma (EWS) and osteosarcoma (OS), which may be partially due to unequal access to evidence based, guideline concordant care. My previous research demonstrated that 50% of AYAs with OS in California received guideline concordant care and that not receiving this care negatively impacted survival. This study seeks to increase the delivery of guideline concordant care to AYAs with OS and EWS to improve overall survival.

PI_NAMEs: ALVAREZ, ELYSIA  (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Administrator;Adolescent and Young Adult;Adolescent and young adult cancer patients;Adoption;Advisory Committees;Age;California;cancer care;Cancer Center;cancer health disparity;Cancer health equity;care delivery;Care given by nurses;care outcomes;career development;Caring;Case Manager;Caucasians;Child;Clinical;Clinics and Hospitals;Community Hospitals;Consolidated Framework for Implementation Research;Data;design;Development;Development Plans;Diagnosis;Disease;Education;Ethnic Origin;Evaluation;evidence base;Evidence based practice;Ewings sarcoma;experience;Foundations;Future;Goals;Guidelines;health equity;Health system;high risk;Hospitals;implementation protocol;implementation science;implementation strategy;implementation trial;improved;improved outcome;Inferior;Institution;Intervention;Interview;K-Series Research Career Programs;Knowledge;Leadership;Maintenance;Malignant Neoplasms;Maps;Mentors;Mentorship;Methods;Modeling;mortality;multidisciplinary;Needs Assessment;Not Hispanic or Latino;Oncology;Osteosarcoma;Outcome;Patient Education;patient population;Patients;Phase;Physicians;pilot test;pilot trial;Population;Positioning Attribute;Process;programs;Protocols documentation;Provider;public health insurance;Qualitative Methods;Qualitative Research;Race;Research;Research Personnel;Research Proposals;Resources;response;Sarcoma;Scientist;Secure;Site;skills;standardized care;Structure;Supportive care;Surveys;survival disparity;survival outcome;Testing;Training;Training Programs;Underserved Population;United States;Work

PROJECT_TITLE: Barriers and Facilitators for Delivery of Guideline-Concordant Care for Adolescents and Young Adults with Ewing Sarcoma and Osteosarcoma

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Pregnancy;Prevention;Women's Health Research

ORG_CITY: Aurora

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE There is a strong need for prevention of perinatal mood, anxiety, and trauma symptoms, as they represent the most prevalent comorbidity in the perinatal period and are associated with the leading cause of maternal mortality – suicide. Patients with high-risk pregnancies and anticipated Cesarean delivery are a large population of patients at increased risk for onset of mental health symptoms in the postpartum period. This project refines and evaluates a low cost, non-pharmacologic, single-session intervention to prevent onset of perinatal mood, anxiety, and traumas symptoms, with the eventual goal of promoting scalability and applicability of the intervention to labor and delivery units across the United States.

PI_NAMEs: DEMPSEY, ALLISON GAIL;WOOD, CRISTINA L (contact)

PROGRAM_OFFICER_NAME: CHU, SERENA PO-LAN

PROJECT_TERMS: Address;Administrator;antenatal;Anxiety;anxiety reduction;anxiety sensitivity;anxiety symptoms;Atmosphere;Beds;Caring;Censuses;Cesarean section;Cognitive Therapy;Communities;community engagement;community partners;comorbidity;cost;Country;Coupled;design;Development;Diagnosis;effective intervention;efficacy evaluation;Environment;Event;Exposure to;Feedback;fetal;Fetus;Fostering;Fright;Future;Goals;high risk;High-Risk Pregnancy;Hospitals;Hour;implementation protocol;implementation research;improved;in vivo;Individual;Intervention;Lived experience;Logic;Maternal Mortality;Mental disorders;Mental Health;Modality;Modeling;mood symptom;Nurses;Operating Rooms;opioid use;Outcome;Participant;patient population;Patients;Pediatric Hospitals;peer;Perinatal;Perinatal Care;perinatal mental health;perinatal period;Phase;pilot trial;Population;Population Heterogeneity;Postoperative Period;Postpartum Period;pregnant;prevent;Prevention;Preventive;preventive intervention;Procedures;Process;Protocols documentation;psychoeducation;Randomized;Randomized, Controlled Trials;reduce symptoms;Reporting;Research;Research Personnel;Resources;Risk;Safety;Site;Suicide;suicide mortality;Symptoms;Testing;Therapeutic Intervention;therapy development;Trauma;trauma symptom;treatment as usual;United States;Update;virtual reality;Work

PROJECT_TITLE: Preventing Maternal Mood, Anxiety, and Trauma Symptoms after Cesarean Delivery

STUDY_SECTION: EMHI

STUDY_SECTION_NAME: Effectiveness of Mental Health Interventions Study Section[EMHI]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: STANFORD

ORG_DEPT: PSYCHIATRY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Sleep is a very well conserved behavioral state across all animals and its precise homeostatic regulation is vital for maintaining good sleep quality and a healthy life. Patients with Alzheimer’s disease (AD) show signs of disrupted sleep architecture characterized by fragmented sleep patterns, and though the exact mechanism underlying fragmented sleep in Alzheimer’s patients remains unknown, it may involve disrupted encoding of homeostatic sleep pressures by wake- promoting hypocretin neurons of the lateral hypothalamus. In this proposal, I will investigate the impact of AD related accumulation of beta-amyloid (Aβ) on hypocretin neuron activity and subsequent impacts on homeostatic sleep pressures and increased sleep fragmentation in AD, with the aim to elucidate the underlying mechanisms driving sleep disturbances in AD – a key step in advancing our understanding of AD progression and treatment.

PI_NAMEs: GONZALEZ, OSCAR CHRISTIAN (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: abeta accumulation;Abeta clearance;Acceleration;Age;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Animals;APP-PS1;Architecture;Arousal;Array tomography;Automobile Driving;Behavioral;Biophysics;Brain;Brain region;Cells;circadian;Clustered Regularly Interspaced Short Palindromic Repeats;comorbidity;Complex;computational network modeling;Computer Models;Death Rate;differential expression;Disease Progression;Down-Regulation;Electroencephalography;Electrophysiology (science);Fiber;Gene Expression;Goals;Homeostasis;hypocretin;Hypothalamic structure;Immunohistochemistry;Impairment;in vivo;interstitial;Ion Channel;Ions;Lateral;Life;Link;Malignant Neoplasms;memory consolidation;Mental Depression;Modeling;Nervous System Disorder;neuron loss;neuronal excitability;Neurons;neuropsychiatric disorder;normal aging;novel;optogenetics;Organism;patch clamp;Pattern;Photometry;predictive modeling;pressure;protein expression;Recording of previous events;Regulation;Research;Risk;Role;Signal Transduction;Sleep;Sleep Apnea Syndromes;Sleep Architecture;Sleep Deprivation;Sleep disturbances;Sleep Fragmentations;sleep pattern;sleep quality;sleep regulation;Sleeplessness;Slice;Stream;Structure;Synapses;Technology;Testing;theories;Time;Transgenic Mice;ultra high resolution;Wild Type Mouse;Work

PROJECT_TITLE: Contribution of hypocretin neuron activity to Alzheimer's related sleep disturbances

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Response to cardiovascular disease (CVD) medications is influenced by many factors including a patient's lifestyle, environment, and genetics. Currently, our knowledge around how to best treat CVD patients using clinical and genetic factors has been largely derived from non-diverse populations. This project will identify characteristics associated with adverse drug responses and adverse cardiovascular outcomes in diverse CVD patients treated with statins and antiplatelet therapy.

PI_NAMEs: MCDONOUGH, CAITRIN W (contact)

PROGRAM_OFFICER_NAME: ANAYA, GABRIEL

PROJECT_TERMS: ABCG2 gene;Academic Medical Centers;Adult;adverse outcome;Aftercare;Algorithms;All of Us Research Program;American;analytical method;Antiplatelet Drugs;Asian ancestry;Asian population;Blood Platelets;Cardiovascular Diagnostic Techniques;Cardiovascular Diseases;Cardiovascular Models;Cardiovascular system;career development;Caring;Characteristics;Clinical;clinical implementation;clopidogrel;computable phenotypes;Consensus;CYP2C19 gene;CYP2C9 gene;Data;Data Set;Data Sources;Databases;design;Development;Electronic Health Record;Enrollment;Environment;Equity;Ethnic Origin;European;European ancestry;experience;Genetic;genomic data;Genomics;Genotype;Geographic Locations;Goals;high risk;Hypertension;improved;inhibitor;inhibitor therapy;Knowledge;Life Style;Lipids;machine learning method;Mentored Research Scientist Development Award;Methodology;Methods;Modeling;Musculoskeletal;National Heart, Lung, and Blood Institute;Outcome;Patient-Focused Outcomes;Patients;Pattern;Persons;Pharmaceutical Preparations;pharmacogenetic testing;phenotyping algorithm;Population;precision medicine;predictive modeling;prevent;programs;Race;Regression Analysis;Research;Research Personnel;response;Risk;rural area;sex as a biological variable;Signal Transduction;skills;Surveys;Symptoms;Testing;trend;United States;wearable device;Work

PROJECT_TITLE: Development of Integrated Precision Medicine Models in Adults with Cardiovascular Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-Z (J2)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Contraception/Reproduction;Lupus;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Pregnancy;Prevention;Women's Health Research

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative: Reproductive rheumatology is an emerging discipline aimed at empowering women with rheumatic disease to safely fulfill their desire for a family. This field requires robust scientific research to offer evidence-based, patient-focused recommendations on pregnancy prevention, planning, and management. The candidate, leveraging her extensive clinical and research expertise in the field, aims to mentor, train, and foster collaborations with the upcoming generation of reproductive rheumatology researchers at Duke University and across the United States.

PI_NAMEs: CLOWSE, MEGAN E.B. (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: active method;Address;adverse outcome;adverse pregnancy outcome;American;Autoimmunity;Award;Biological Markers;Birth Rate;career;Caring;Child;Clinical;Collaborations;college;Communities;Congenital Abnormality;Consensus;Contraceptive methods;Data;Data Analyses;Decision Making;Dedications;Department of Defense;design;Discipline;empowerment;Ensure;evidence base;experience;Faculty;Family;Fostering;Foundations;Funding;Generations;Goals;Grant;hands on research;health of the mother;High-Risk Pregnancy;implementation science;improved;improved outcome;Industry;innovation;International;Intervention Trial;Knowledge;lectures;Lived experience;Lupus Nephritis;Manuscripts;Maternal Health;Medical Students;meetings;Mentors;Methods;Minority Women;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Nephritis;next generation;novel;optimal treatments;Oral;Outcome;patient oriented;patient oriented research;Patients;peer;Planned Pregnancy;Pre-Eclampsia;Pregnancy;Pregnancy loss;pregnancy prevention;Pregnant Women;Premature Birth;programs;Provider;Publishing;Qualifying;Recommendation;recruit;Registries;reproductive;Reproductive Health;Research;Research Personnel;Research Project Grants;Research Support;resilience;Rheumatism;Rheumatoid Arthritis;rheumatologist;Rheumatology;Risk;Risk Factors;Science;Scientist;skills;statistics;Surveys;Systemic Lupus Erythematosus;Teleconferences;Teratogens;Testing;Thinking;Time;tool;Training;Underrepresented Minority;United States;Universities;Vasculitis;web site;Woman;Women's Group;Women's Health;women's outcomes;women's reproductive health;Work;young woman

PROJECT_TITLE: K24 Advancing Reproductive Rheumatology

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Obstructive Pulmonary Disease;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Lung;Prevention;Social Determinants of Health

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Wildfire smoke is toxic air pollution that disproportionately impacts those with low socioeconomic status. The goal is to mitigate exposure of high-risk patients with chronic obstructive pulmonary disease and low socioeconomic status to wildfire smoke in order to prevent hospitalization and improve health equity.

PI_NAMEs: MYERS, LAURA CHRISTINE (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: advanced analytics;Air;air cleaner;Air Pollution;airway inflammation;American;Area;arm;behavior change wheel;Board Certification;Burn injury;California;career;Catchment Area;Cause of Death;Chest;Chronic Obstructive Pulmonary Disease;Circulation;climate change;Clinical;Clinical Trials;Clinical Trials Design;Critical Care;Data;data resource;design;Diameter;Education;effective intervention;Effectiveness of Interventions;Electronic Health Record;Environmental Exposure;Equipment;experience;Exposure to;fine particles;Flare;Foundations;Future;Geography;Goals;Health;Health Care Costs;health equity;high risk;Home;Hospitalization;Hour;improved;indoor air;innovation;Integrated Delivery of Health Care;Intervention;Interview;Knowledge;low socioeconomic status;Lung;Masks;Mentors;Methodology;Methods;Modeling;mortality;multi-component intervention;N95 mask;Newly Diagnosed;Outcome;particle;Particulate Matter;Patients;Performance;Persons;Physicians;Policies;portability;Positioning Attribute;predictive modeling;prevent;professor;Qualitative Methods;Quality of life;Randomized;Research;Research Personnel;Resources;risk prediction;Risk Reduction;San Francisco;seal;Site;skills;Smoke;social health determinants;Societies;Socioeconomic Status;Source;Stream;Structure of parenchyma of lung;System;Testing;therapy design;Time;tool;Toxic effect;Training;United States National Institutes of Health;ventilation;Wildfire;Work

PROJECT_TITLE: Preventing hospitalizations for COPD exacerbations due to air pollution from wildfire smoke


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: Chicago

ORG_DEPT: CHEMISTRY

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: PROJECT NARRATIVE  The intersection of nanomaterials and biology has produced promising tools for selective drug delivery, bio- imaging, and biosensing. This project will design structured nano- and microscale materials with topographical features similar to that of the extracellular matrix. This platform to investigate nano-bio interfaces will allow control over cellular motion, adhesion, and shape that will then enable more targeted diagnostics and therapeutics.

PI_NAMEs: ODOM, TERI WANG (contact)

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TITLE: Biomimetic Spiky Nanoparticle Arrays as Tools to Explore Curvature Enhanced Nano-Bio Interactions

STUDY_SECTION: INN

STUDY_SECTION_NAME: Innovations in Nanosystems and Nanotechnology Study Section [INN]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: HAMILTON

ORG_NAME: MCMASTER UNIVERSITY

ORG_STATE: ON

ORG_ZIPCODE: L8S 4K1

PHR: PROJECT NARRATIVE This project aims to develop and distribute an open-source software tool for precise anatomical localization of time-locked neural processes from single-trial M/EEG. This tool will facilitate and improve research into the nature and localization of neural processes. In the future, work using the tool may lead to clinical applications such as improved pre-surgical mapping for epilepsy.

PI_NAMEs: BRODBECK, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: LIU, CHRISTINA HUANG

PROJECT_TERMS: Acoustics;Adoption;Algorithms;analysis pipeline;Anatomy;Auditory area;base;Bayesian Modeling;Benchmarking;Brain;BRAIN initiative;clinical application;Code;cognitive process;Communities;computer scientist;Computer software;connectome;cost;Data;Data Analyses;data exploration;Data Set;Data Sources;Databases;design;Development;Documentation;education resources;Educational workshop;Electroencephalography;Epilepsy;Event;Experimental Designs;Experimental Models;experimental study;flexibility;Formulation;Functional Magnetic Resonance Imaging;Future;Head;hemodynamics;Human;improved;Infrastructure;innovation;Intuition;Knowledge;Language;Location;machine learning method;Magnetic Resonance Imaging;Maps;Measurement;Measures;mental state;Methods;millisecond;Modeling;Motion;Movement;movie;Multivariate Analysis;Music;Nature;neural;neurophysiology;Noise;novel;open data;open source;Participant;Performance;podcast;Process;Psychologist;Pythons;repository;Research;Research Personnel;Resolution;response;Scientist;sensor;Sensory Process;Series;Signal Transduction;skills;Software Tools;Source;source localization;Specific qualifier value;Speech;statistics;Stimulus;System;Techniques;temporal measurement;Testing;Time;tool;user-friendly;Variant;Vision;Visual;Visual Cortex;Visual Motion;Visualization;web site;Work

PROJECT_TITLE: User-friendly open-source pipeline for anatomically precise analysis of single-trial M/EEG

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-G (02)]


ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE Despite successful treatment with blood flow restoration, ischemic stroke remains a major cause of disability in the U.S., disproportionately impacting older adults. In this study, we will examine the significance and role of neutrophils in brain injury following ischemic stroke and determine how aging affects neutrophil recruitment and persistence. Results from this work will lay the foundation for future studies examining novel treatments for ischemic stroke beyond blood flow restoration, and has broad potential translation to other aging-related brain disorders.

PI_NAMEs: BATRA, AYUSH  (contact);SULLIVAN, DAVID PATRICK

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Acute;acute stroke;Address;Affect;Age;age related changes;aged;Aging;aging brain;aging related;Animal Model;Beds;Blood;Blood flow;Brain;Brain Diseases;Brain Injuries;Brain Ischemia;brain tissue;cell type;Clinical;Clinical Trials;cytokine;Data;Data Set;Development;disability;Disease;Disparity;experimental study;Foundations;Future;Gene Expression;Gene Expression Profile;Germ Cells;Human;Impairment;in vivo;Inflammation;Inflammatory Response;Injury;Ischemia;ischemic injury;Ischemic Stroke;juvenile animal;Knockout Mice;Knowledge;Label;Leukocytes;life span;Location;Longevity;Mediating;Middle Cerebral Artery Occlusion;Modeling;Mus;Nervous System Trauma;neutrophil;Neutrophil Infiltration;new therapeutic target;novel;NR4A2 gene;Nuclear Receptors;old mice;older adult;Organ;Outcome;Pathologic;Patients;Play;Positioning Attribute;post stroke;pre-clinical;preclinical study;prevent;Reactive Oxygen Species;Recovery;recruit;Reperfusion Injury;Reperfusion Therapy;response;restoration;Role;Severities;spatiotemporal;Stroke;stroke outcome;stroke therapy;Surface;Techniques;Testing;Therapeutic;Time;transcription factor;translational potential;Up-Regulation;Work;young adult

PROJECT_TITLE: Aging Exacerbates Neutrophil Persistence and Negatively Impacts Stroke Outcomes

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Transcranial Magnetic Stimulation (TMS) is a rapidly growing intervention for some of the most serious and intractable forms of psychopathology, like treatment-resistant depression (TRD). A crucial structure that regulates neuronal function is the blood-brain barrier (BBB), which has thought to be impaired in depression and capable of being influenced by TMS. The proposed training and research plan will focus on elucidating the mechanism TMS, whereby it may improve the BBB in TRD, demonstrating a modifiable target to improve depressive symptoms.

PI_NAMEs: GOLDWASER, ERIC LURIA (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Acceleration;Address;Aftercare;Age;age group;Area;arterial spin labeling;Automobile Driving;Biological;Bipolar Depression;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Tests;Blood Vessels;blood-brain barrier function;Brain;Brain Neoplasms;career;cell type;Cellular biology;Cerebrospinal Fluid;Cerebrovascular Circulation;Cerebrum;chemotherapy;Clinical;Clinical Trials;comorbidity;depressive symptoms;Diffusion;disability;effective therapy;Engineering;experimental study;FDA approved;Foundations;Functional disorder;functional improvement;Future;Genetic Complementation Test;Goals;Homeostasis;Hospitals;Impairment;improved;in vivo;Injections;insight;Institution;Insulin;Insulin Resistance;Intervention;Learning;Link;Magnetic Resonance Imaging;Measurement;Measures;Mediation;Mediator;Medicine;Mental Depression;Mentored Patient-Oriented Research Career Development Award;Mentors;Metabolic;Metformin;Methods;Modeling;Molecular Biology;Mutation;neuroimaging;Neurons;neurovascular unit;New York;novel;Onset of illness;Outcome;patient subsets;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;Physicians;Physics;Play;Postdoctoral Fellow;pre-clinical research;Prefrontal Cortex;Presbyterian Church;programs;Proteins;Protocols documentation;Psychiatrist;Psychiatry;Psychopathology;Publishing;Research;Research Personnel;Resistance;response;Rodent;Role;safety and feasibility;Schedule;Schizophrenia;sex;Signal Transduction;social stressor;Specificity;Structure;symptom treatment;symptomatic improvement;Symptoms;Techniques;Testing;Therapeutic Effect;therapy development;therapy resistant;Training;Transcranial magnetic stimulation;treatment comparison;Treatment outcome;Treatment Protocols;treatment-resistant depression;Vascular Endothelium;white matter;Work

PROJECT_TITLE: Blood-brain barrier modulation by transcranial magnetic stimulation as a mechanism in depression treatment

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-R (02)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: MARC @ Georgia State University (GSU) is a thriving undergraduate (UG) biomedical research training program for students from underrepresented (UR) groups in STEM, established in 2019 and poised to launch a new MARC grant from 2024-2029. GSU has taken institutional responsibility for ensuring efficient and effective trajectories through undergraduate studies for students from all backgrounds, and MARC lends richness to this college experience through mentored research, enhanced course work, professional development workshops, and career planning. Based on institutional assessment, education science, and lived experiences among students, faculty, and staff at GSU and our partner organizations, the program plan for MARC@GSU is ready to equip and empower students with the skills and dispositions that will propel them into successful and satisfying careers in the U.S. biomedical research workforce.

PI_NAMEs: FRANTZ, KYLE J. (contact);GAUCHER, ERIC

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Alabama;Assistantship;Benchmarking;Biology;Biomedical Research;Biotechnology;career;Career Exploration;CCL7 gene;Chemistry;Collaborations;Coupled;Degree program;Development;Doctor of Philosophy;Education;education research;Educational workshop;Elements;empowerment;Environment;evidence base;externship;Goals;graduate school;Grant;health disparity;holistic approach;Inequity;Institution;Life;Lived experience;Mentors;Neurosciences;Population;programs;Psychology;Public Health;Research;Science;Scientific Advances and Accomplishments;Self Efficacy;skill acquisition;skills;Students;symposium;Thinking;Training;Training Programs;Travel;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities

PROJECT_TITLE: MARC at Georgia State University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases;Telehealth;Wound Healing and Care

ORG_CITY: PORTLAND

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Americans fear blindness more than virtually any other health problem, and the enormous impact of these conditions will accelerate as our population ages. Fortunately, advances in scientific knowledge and technology hold great promise for alleviating these problems. This proposal provides protected, start-up support for junior faculty clinicians to develop the clinical research skills necessary to make this promise a reality and reduce the suffering and impairment of blinding eye diseases.

PI_NAMEs: HUANG, DAVID  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Advisory Committees;Angiography;Area;Artificial Intelligence;Award;Basic Science;Biological;Blindness;career;Clinical;Clinical Research;Clinical Trials;Cornea;Corneal Ulcer;Databases;deep learning;Devices;Disease;Early Diagnosis;Educational Curriculum;Educational workshop;Electronic Health Record;experience;Expert Systems;Exposure to;Eye;Frequencies;Funding;Genetic;Glaucoma;Goals;Grant;hands on research;Human;Image;improved;Informatics;International;Intervention;Lead;Leadership;Manuscripts;Mentored Clinical Scientist Development Program;Mentors;Monitor;Mycoses;Ophthalmology;Optical Coherence Tomography;Patient Care;Patients;programs;Reading;Reproducibility;Research;Research Methodology;responsible research conduct;Retinopathy of Prematurity;Risk Factors;Science;Scientist;Severities;Source;Specialist;System;Teacher Professional Development;Technology;Telemedicine;Time;Training;Training Programs;Translating;Universities;Vision;Vision research;vision science;Work;Writing

PROJECT_TITLE: Mentored Vision Clinician-Scientist Program at OHSU

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (05)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Pregnancy;Prevention;Serious Mental Illness;Social Determinants of Health;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE One in four women in South Asia, including India are affected by perinatal depression. Marital-level relationship risk factors such as poor relationship dynamics, limited spousal support, and women's low decision-making, particularly in the context of early marriage and childbearing, increase women’s vulnerability to perinatal depression, yet trials investigating couples-based interventions for prevention of perinatal depression remain unexplored. The project aims to culturally adapt and pilot test a couples-based intervention to prevent perinatal depression among primiparous (first-time pregnant) couples in rural India.

PI_NAMEs: GOPALAKRISHNAN, LAKSHMI  (contact)

PROGRAM_OFFICER_NAME: KOSO-THOMAS, MARION

PROJECT_TERMS: Address;Affect;antenatal;Asia;Award;Birth Weight;career;Career Mobility;Child;child bearing;Child Health;Child Rearing;Communication;Community Health Aides;Country;Couples;Data;Data Analyses;Decision Making;Development;Dimensions;early childbearing;Educational workshop;effective intervention;Elderly woman;Enrollment;Equity;Evidence based intervention;experience;Family;Feedback;Focus Groups;follow-up;Goals;Health;Health behavior;health of the mother;Health Sciences;health seeking behavior;Husband;Impairment;implementation science;improved;Income;India;Inequity;Infant;Intervention;intervention refinement;Intervention Studies;Interview;intimate partner violence;Knowledge;Life Cycle Stages;low and middle-income countries;Low Birth Weight Infant;Low income;Marital Relationships;Marriage;Maternal and Child Health;Maternal Health;Mediator;member;Mental Depression;Mentors;Mothers;multidisciplinary;National Institute of Child Health and Human Development;neonatal health;offspring;operation;Outcome;Pathway interactions;perinatal mental health;perinatal period;peripartum depression;Phase;Phase Transition;Pilot Projects;pilot test;population health;postnatal;Postpartum Depression;Postpartum Period;preference;Pregnancy;pregnant;Pregnant Women;Prevalence;prevent;Prevention;Preventive;preventive intervention;primary outcome;Process;psychologic;Randomized;Randomized, Controlled Trials;Research;Research Personnel;Risk;Risk Factors;routine care;Rural;Sample Size;Sampling;satisfaction;scale up;Series;shared decision making;skills;Social support;staff intervention;standard of care;suicidal risk;Surveys;Testing;therapy development;Time;Training;Treatment Efficacy;trial design;Woman;Women's Health;women's outcomes;Work

PROJECT_TITLE: Adaptation and pilot testing of a couples-based intervention to prevent perinatal depression in rural India

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-C (02)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE We invented a Point-of-care Portable Perfusion Phantom (P4), which allows reproducible quantitative DCE-MRI measurement across MRI platforms. We demonstrated that quantitative DCE-MRI after P4-based error correction could assess the pancreatic cancer response to therapy early. In this study, we propose a clinical trial of DCE-MRI-guided neoadjuvant chemotherapy to improve the negative-martin resection for patients with borderline resectable pancreatic cancer.

PI_NAMEs: EL-RAYES, BASSEL ;KIM, HARRISON  (contact);MASOOD, ASHIQ

PROGRAM_OFFICER_NAME: DARDZINSKI, BERNARD JOSEPH

PROJECT_TERMS: Abdomen;Academic Medical Centers;Acute;Adjuvant Chemotherapy;Age;Alabama;arm;Arteries;Assessment tool;Blood Vessels;Categories;Cellularity;chemotherapy;clinical practice;Clinical Trials;contrast enhanced;Contrast Media;Control Groups;Data;density;design;Diagnosis;digital;Disease Progression;Early identification;Early treatment;effective therapy;Evaluation;Excision;feeding;follow-up;gemcitabine;Goals;Health Insurance;Histopathology;Image;image guided;improved;In complete remission;Indiana;interstitial;Intravenous;invention;Location;Magnetic Resonance Imaging;Malignant neoplasm of pancreas;Measurement;Measures;Metastatic Pancreatic Adenocarcinoma;Methods;Monitor;Morphology;Movement;Names;Necrosis;Neoadjuvant Therapy;Neoplasm Metastasis;Oncology;operation;Operative Surgical Procedures;Paclitaxel;Pancreas;Pancreatic Adenocarcinoma;pancreatic cancer patients;pancreatic neoplasm;partial response;Participant;Patient Recruitments;Patients;Performance;Perfusion;personalized medicine;Pilot Projects;point of care;Policies;portability;pressure;primary endpoint;Prognosis;Progressive Disease;Race;Regimen;Reproducibility;Resectable;Resected;response;Scanning;Sclerosis;secondary endpoint;sex;Signal Transduction;Solid Neoplasm;Stable Disease;standard of care;Subcategory;Survival Rate;Technology;Testing;Therapeutic;Time;Tissues;tool;Translating;treatment planning;treatment response;tumor;tumor microenvironment;Universities;Veins

PROJECT_TITLE: DCE-MRI guided Neoadjuvant Chemotherapy for Borderline Resectable Pancreatic Cancer

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Mental Health;Social Determinants of Health;Telehealth

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Novel strategies are needed to increase mental health clinicians' use of evidence-based interventions to improve the quality of mental health care. This R34 will develop and pilot-test a behavioral economics-informed telehealth platform designed to nudge and incentivize community mental health clinicians to use core structural components of cognitive behavioral therapy (CBT) to improve overall CBT fidelity and patient outcomes.

PI_NAMEs: CREED, TORREY A.;HAIMES, EMILY MICHELE BECKER (contact)

PROGRAM_OFFICER_NAME: DAVIS, BESHAUN JAMAAL

PROJECT_TERMS: acceptability and feasibility;Achievement;Adoption;Assessment tool;Attitude;behavior change;behavioral economics;behavioral health;Client satisfaction;Clinical;Code;cognitive change;Cognitive Therapy;Collaborations;common treatment;Communities;Competence;COVID-19;COVID-19 pandemic;design;Development;Diagnostic;Disparity;Drops;economic impact;Effectiveness;effectiveness/implementation hybrid;Electronics;Elements;Environment;Ethical Issues;Ethics;evidence base;Evidence based intervention;Evidence based practice;experience;Feedback;field study;Foundations;Goals;health care settings;Health Services Accessibility;implementation efforts;implementation strategy;improved;Incentives;indexing;Infrastructure;Instruction;Internet;Intervention;Interview;Judgment;marginalized population;Measurable;Measurement;Measures;Mental Health;Mental Health Services;Methods;Modeling;Monitor;National Institute of Mental Health;Nature;novel;novel strategies;Office Visits;open data;Outcome;Patient-Centered Care;Patient-Focused Outcomes;Patients;Persons;pilot test;pilot trial;post-pandemic;primary outcome;Privacy;Procedures;Process;Protocols documentation;prototype;provider behavior;psychosocial;Quality of Care;Questionnaires;Randomized;Recommendation;Research;Rewards;secondary outcome;Self Efficacy;Services;shared decision making;skills;Strategic Planning;Structure;support tools;Surveys;Symptoms;Techniques;Technology;telehealth;telepsychology;Testing;theories;Therapeutic;tool;uptake;user centered design;Voice;Work

PROJECT_TITLE: Leveraging telepsychology and behavioral economics to increase fidelity to CBT

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Adolescent Sexual Activity;American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Substance Misuse;Teenage Pregnancy;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Culturally grounded strengths-based interventions hold significant promise to reduce and prevent substance misuse and consequential overdoses among Native Americans. The well-established Traditional Ecological Knowledge theoretical framework informs the nature-based culturally grounded (NBCG) substance misuse intervention by positing cultural and spiritual mechanisms between nature-based experiential learning of traditional practices and cultural protocols (NBCG intervention) and resilience and resistance to substance misuse. In partnership with the Confederated Salish and Kootenai Tribes tribal community, we aim to develop and refine the NBCG intervention, and evaluate successful implementation strategies that will set the stage for a future fully powered Hybrid type II trial to measure implementation and program effectiveness against maternal substance misuse and child problem emotional and behavioral development.

PI_NAMEs: RUSSETTE, HELEN  (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: Abstinence;acceptability and feasibility;Active Learning;addiction;Address;Advocate;Age;Alcoholic Liver Diseases;Alcohols;Behavior;Behavior Therapy;Behavioral;Black, Indigenous, People of Color;career;Child;Clinical Trials;Communities;COVID-19;COVID-19 pandemic;Death Rate;Deaths of despair;Decision Making;design;Development;Discrimination;Effectiveness;Effectiveness of Interventions;Emotional;Enrollment;Environment;Evaluation;evidence base;Evidence based intervention;experience;Family;Fostering;Future;Generations;Goals;Ground Substance;Health;health inequalities;Home visitation;Human;hybrid type 2 trial;implementation evaluation;implementation measures;implementation science;implementation strategy;implementation/effectiveness;improved;Indigenous;Inequity;intergenerational;Interpersonal Violence;Intervention;Intervention Studies;Interview;Investigation;Knowledge;Life;Measures;Mentors;Methods;Modeling;Mothers;National Institute of Drug Abuse;Native American population;Native Americans;Nature;novel;Overdose;Personal Satisfaction;Persons;Pharmaceutical Preparations;Policies;Program Effectiveness;programs;Protocols documentation;Randomized;randomized trial;Recording of previous events;recruit;Research;Research Design;Research Personnel;resilience;Resistance;response;Risk;Risk Factors;Risk Taking;Salish and Kootenai;Sample Size;satisfaction;Seasons;Sleep disturbances;sleep quality;sobriety;social interventions;Spirituality;statistics;Structure;Substance abuse problem;substance misuse;substance misuse prevention;Substance Use Disorder;success;Suicide;teenage mother;Testing;therapy design;tool;Training;Trauma;trial design;tribal community;tribal leader;Tribes;unintended pregnancy;Waiting Lists;Water;Work;young mother;young woman

PROJECT_TITLE: Applying the Traditional Ecological Knowledge framework to develop and evaluate a nature-based culturally grounded substance misuse intervention for Native American families.

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: NEUROSURGERY

PHR: PROJECT NARRATIVE Activity-dependent myelination is an emerging facet of neuroplasticity in which neuronal activity stimulates new myelin formation by oligodendrocytes. Although numerous studies have demonstrated the importance of activity-dependent myelination for learning, cognition, and memory, how neuronal activity drives myelin membrane expansion in oligodendrocytes is unclear. My proposed research will reveal fundamental cellular mechanisms of activity-dependent myelination that may be harnessed as therapeutic strategies to promote myelin regeneration and neuronal health in neurological disease and disorders.

PI_NAMEs: LAM, MABLE  (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Acceleration;Action Potentials;Adhesions;Adult;Affect;Alzheimer's Disease;Axon;Behavior;Behavioral;Behavioral Assay;Biological Assay;Botulinum Toxins;bridge program;Cell Culture Techniques;Cell surface;cell type;cellubrevin;Coculture Techniques;Cognition;cognitive ability;Cognitive deficits;Communication;Complex;Cues;Data;disability;Exocytosis;Exocytosis Inhibition;experience;experimental study;extracellular;Future;Glutamates;Health;Human;human induced pluripotent stem cells;human model;in vivo;Individual;inducible Cre;Interdisciplinary Study;Laboratories;Laboratory Research;Learning;Length;Measures;Mediating;Membrane;Memory;Mentors;Morphology;Motor;Motor Cortex;motor learning;Multiple Sclerosis;Mus;Myelin;Myelin Sheath;myelination;Natural regeneration;Nervous System Disorder;neural circuit;neurodevelopment;Neuroglia;Neuronal Plasticity;Neurons;Neurotransmitters;Oligodendroglia;optogenetics;Parkinson Disease;Pattern;Persons;physically handicapped;Positioning Attribute;Postdoctoral Fellow;prevent;Process;Proteins;rate of change;Research;response;Retinal Ganglion Cells;Rodent;Rodent Model;Role;Running;Sensory;spatiotemporal;Stimulus;Structure;System;Testing;Therapeutic;Thick;tool;trafficking;Training;Transgenic Mice;vesicular SNARE proteins;Work

PROJECT_TITLE: Mechanisms of activity-dependent myelination through oligodendrocyte exocytosis

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: MENLO PARK

ORG_NAME: SRI INTERNATIONAL

PHR: PROJECT NARRATIVE This research is relevant to public health because it utilizes our current platform of cell-based delivery to deliver proteins that can target cancer cells via autocrine signaling. This effort is relevant to NCI's mission because no approach is currently available for delivering calibrated amounts of therapeutic proteins specifically to the tumor sites and without impacting healthy cells.

PI_NAMEs: RADHAKRISHNAN, HARIKRISHNAN  (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Achievement;advanced disease;Adverse event;Animal Model;anti-tumor agent;Antibodies;Antigen Presentation;Antigens;antitumor effect;Autocrine Communication;Biological Availability;Calibration;cancer cell;Cancer Cell Growth;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;cellular engineering;clinical translation;Complement Activation;Cyclic GMP;Cytolysis;Data;Disease;DNA Damage;Dose;efficacy evaluation;efficacy study;engineered T cells;Engineering;Enhancement Technology;Enzymes;Exhibits;experimental study;Extracellular Matrix;FOLR1 gene;Grant;Half-Life;Human;Immune system;Immunocompetent;immunogenic;Immunosuppression;improved;In Vitro;in vivo;innovation;interferon therapy;Interferon Type I;Interferon-beta;Interferons;Kidney;Malignant neoplasm of ovary;mesothelin;Mission;MMP8 gene;mouse model;Mus;neoplastic cell;Nerve Degeneration;Outcome;Pathway interactions;Pilot Projects;preclinical study;Process;Productivity;Proteins;Protocols documentation;Public Health;Publications;Radiation;Reporter;Reporting;Research;Research Personnel;Residual Neoplasm;response;scale up;Serous;side effect;Site;Solid Neoplasm;System;systemic toxicity;T-Lymphocyte;Testing;therapeutic protein;Tissues;Toxic effect;Tubular formation;tumor;Tumor Antigens;Tumor Burden;tumor microenvironment;Validation;Work

PROJECT_TITLE: Pilot in vivo trial with T-cell-based delivery of immunostimulatory proteins

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-O (J1)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE Whole-body MRI scanners face limited accessibility due to their high expense and specific siting requirements, which can substantially increase costs. MRI suites rely on a costly Faraday shielded room to eliminate image artifacts caused by external radio waves as well as reduce radio wave emission which can disrupt nearby hospital equipment. We aim to enhance MRI accessibility and reduce expenses by replacing the Faraday shield with a combination of strategically placed passive EM absorbers within the MRI bore and an active cancellation system based on the parallel transmission (pTx) technology.

PI_NAMEs: KAZEMIVALIPOUR, EHSAN  (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: Abdomen;Address;Architecture;Area;Attention;Attenuated;Award;Biomedical Engineering;Body Size;Body System;career;Clinical;clinical application;Collaborations;Communities;computing resources;cost;Data;Dedications;design;Developing Countries;Development;Dimensions;electric field;Electromagnetics;Engineering;Ensure;Environment;Equipment;experimental study;Face;Frequencies;General Hospitals;Geometry;Goals;Health;healthy volunteer;heart imaging;high standard;Hospital Equipment;Human body;human subject;Image;Imaging technology;Improve Access;improved;Infrastructure;innovative technologies;interest;Limb structure;Location;Magnetic Resonance Imaging;Massachusetts;Measures;Medical;Mentors;Mentorship;meter;Methods;Modeling;Morphologic artifacts;Nervous System Disorder;neuroimaging;new technology;non-invasive imaging;noninvasive diagnosis;novel strategies;operation;Patient Care;Patients;Pattern;Pelvis;Performance;Phase;Physics;Physiologic pulse;Population;Population Heterogeneity;portability;Positioning Attribute;Posture;programs;prototype;Radiation;radiation mitigation;radio frequency;Radio Waves;Regulation;Research;Research Personnel;rural area;Safety;Shapes;Somatotype;System;Technology;technology development;Testing;Thick;tool;Training;Training Programs;transmission process;Variant;whole body imaging;Work

PROJECT_TITLE: Toward unshielded MRI for improved safety and access

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-F (J1)]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Immunization;Immunotherapy;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HOUSTON

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE: Drug resistance is a major cause of therapy failure in colorectal cancer patients largely due to tumor heterogeneity and the existence of cancer stem cells. The goal of this project is to generate novel bispecific antibody-drug conjugates (BsADCs) directed against two tumor targets that can eliminate cancer stem cells and overcome therapy resistance. BsADCs will be evaluated in patient-derived tumor models and a lead candidate will be identified for the future development of a new therapeutic to treat colorectal cancer.

PI_NAMEs: CARMON, KENDRA S. (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Ablation;Adverse effects;Affinity;Aftercare;Antibodies;Antibody-drug conjugates;Back;Binding;Bispecific Antibodies;BRAF gene;cancer cell;cancer stem cell;Cells;Cetuximab;Chemistry;chemotherapy;clinical efficacy;Clinical Trials;colon cancer cell line;colon cancer patients;Colorectal Adenoma;Colorectal Cancer;colorectal cancer treatment;comparative efficacy;cytotoxic;Development;Disease Progression;Drug resistance;effective therapy;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Excision;Exhibits;experience;Future;G-Protein-Coupled Receptors;Genetic;Glutaminase;Goals;Growth;Heterogeneity;Immune checkpoint inhibitor;Immunocompetent;Immunotherapy;improved;In Vitro;in vivo imaging system;knock-down;KRAS2 gene;Lead;lead candidate;Leucine-Rich Repeat;LGR5 gene;metastatic colorectal;Methods;microbial;Microsatellite Instability;Modeling;Monitor;Mus;mutant;Mutation;mutational status;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutics;Organoids;Parents;Pathway interactions;patient subsets;Patients;Pharmaceutical Preparations;Play;Pre-Clinical Model;prevent;Primary Neoplasm;Refractory;Relapse;Residual Cancers;Resistance;Resistance development;Role;Safety;self-renewal;Solid Neoplasm;Specificity;stem cells;subcutaneous;success;systemic toxicity;targeted treatment;Testing;Toxic effect;Treatment Efficacy;Treatment Failure;tumor;Tumor Antigens;tumor heterogeneity;tumor progression;tumorigenesis;WNT Signaling Pathway

PROJECT_TITLE: Bispecific drug-conjugates for treating colorectal cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-Z (J1)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE Youth-onset type 2 diabetes significantly contributes to the increasing prevalence of diabetic kidney disease, yet our understanding of modifiable risk factors remains limited. This study seeks to explore the role of exposure to per- and polyfluoroalkyl substances (PFAS), an emerging environmental risk factor, in the onset and progression of diabetic kidney disease among youth with type 2 diabetes by integrating data on PFAS exposure with data on metabolites and proteins linked to uremic toxicity. This research project will enhance understanding of the health impacts of PFAS, thereby supporting PFAS regulation and helping develop innovative strategies for early identification and prevention of diabetic kidney disease.

PI_NAMEs: GOODRICH, JESSE ALLEN (contact)

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: Acceleration;Adolescence;Adolescent;Adolescent and Young Adult;Adult;Advisory Committees;Albuminuria;amino acid metabolism;Amino Acids;analytical method;Archives;Aromatic Amino Acids;Beta Cell;Biological;Biological Factors;Blood;blood glucose regulation;Cell Physiology;Cessation of life;Chemicals;Chronic Kidney Failure;clinical care;Clinical Data;consumer product;Critical Pathways;Cross-Sectional Studies;Data;data integration;Development;Diabetic Nephropathy;Dialysis procedure;Disease;Disease Progression;disorder risk;disorder subtype;Early identification;early onset;effective therapy;Environmental Exposure;Environmental Health;Environmental Risk Factor;epidemiologic data;Exposure to;Future;Glucose;Goals;Health;high risk;impaired glucose tolerance;Impairment;Incidence;Individual;Industrial Product;Inflammation;Inflammatory;Injury to Kidney;innovation;Instruction;Insulin-Dependent Diabetes Mellitus;Interleukin-6;Intervention;Kidney Failure;Lesion;life span;lifestyle intervention;lifetime risk;Link;link protein;longitudinal analysis;Longitudinal cohort;Longitudinal Studies;Manuscripts;Measures;Mentors;Mentorship;metabolomics;Methods;modifiable risk;Molecular Epidemiology;Multiomic Data;multiple omics;National Institute of Environmental Health Sciences;Newly Diagnosed;Non-Insulin-Dependent Diabetes Mellitus;novel;Participant;Pathway interactions;personalized intervention;Plasma;Poly-fluoroalkyl substances;Population;Populations at Risk;premature;Prevalence;prevent;Prevention;Prevention strategy;prospective;Prospective Studies;Proteins;Proteomics;Proxy;Puberty;recruit;Regulation;Renal function;Research;Research Personnel;Research Project Grants;Resources;Risk;Risk Factors;Role;Sampling;Site;Subgroup;Survival Analysis;symposium;Testing;therapeutic biomarker;Therapeutic Intervention;therapeutic target;TNF gene;Toxic effect;Toxic Environmental Substances;Toxin;Training;type I and type II diabetes;United States;Uremia;Visit;young adult;Youth

PROJECT_TITLE: PFAS and Diabetic Kidney Disease in Young Onset Type 2 Diabetes: Emerging Risk Factors and Underlying Mechanisms

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LWJ-W (K0)]


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Cancer;Liver Disease;Orphan Drug;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project narrative Fat accumulation in the liver causes two major changes in liver cells: it alters the use and production of energy upsetting liver metabolism, and it drives abnormal gene expression patterns that drive malignancy. To date, no one has connected these two major events at the molecular level to define how aberrant metabolites affect the enzymes that control gene expression. We propose to do this here in order to find the metabolic Achilles heel of fatty liver and stop its development into liver cancer with inhibitors of the enzymes that are regulated by liver metabolites and control growth genes.

PI_NAMEs: MARTINEZ, ELISABETH D (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Affect;alpha ketoglutarate;anti-cancer treatment;Binding;Biological Markers;Biology;Blood;Catalysis;Chromatin;Chromatin Remodeling Factor;Citric Acid Cycle;Clinical Trials;clinically relevant;combat;cost;Development;Disease;Dose Limiting;efficacy evaluation;Energy Metabolism;Enzyme Inhibitor Drugs;enzyme substrate;Enzymes;Epigenetic Process;epigenome;Event;Family member;Fatty acid glycerol esters;Fatty Liver;fatty liver disease;Fumarates;Future;Gene Abnormality;Gene Expression;Gene Expression Profile;Genes;Growth;Hepatic;Hepatocyte;high risk;histone demethylase;histone methylation;Human;in vivo;in vivo Model;Inflammatory;inhibitor;Lipids;Liver;liver metabolism;Malignant neoplasm of liver;Malignant Neoplasms;Measurable;Measures;Mediating;Metabolic;Metabolism;mitochondrial dysfunction;Molecular;Mus;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;Normal Cell;obese person;Obesity;Oncogenic;overexpression;Patient Selection;Patients;personalized medicine;predictive marker;prevent;Prevention;Primary carcinoma of the liver cells;Production;response;response biomarker;Risk Factors;Selection Criteria;small molecule inhibitor;Succinates;Testing;Therapeutic;therapeutic target;therapy resistant;Toxic effect;transcriptome;tumor;Work

PROJECT_TITLE: Jumonji enzyme action in hepatocellular carcinoma onset

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-F (J2)]


NIH_SPENDING_CATS: Chronic Pain;Contraception/Reproduction;Endometriosis;Genetics;Neurosciences;Pain Research;Women's Health Research

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Endometriosis is a painful gynecological inflammatory disease with limited therapeutic options that affects up to 15% of people born with uterus. Here, we propose to validate CGRP/RAMP1 blocking drugs as well as macrophage-targeting drugs as novel non-hormonal and non-opioid approaches for the treatment of endometriosis-associated pain. The project also addresses a previous unknown mechanism by which CGRP contributes to a pro-endometriosis phenotype in macrophages and pinpoints the specific nociceptor-responsive macrophage population that drives omental colonization.

PI_NAMEs: FATTORI, VICTOR  (contact)

PROGRAM_OFFICER_NAME: AHN, HELENA HYESOOK

PROJECT_TERMS: Ablation;Address;Advisory Committees;Affect;Age;Analgesics;Area;Award;Bioinformatics;career development;cell growth;Cell Line;Cells;Chemicals;Chronic;Communication;comorbidity;Data;Development;Development Plans;Diagnosis;Disease;driver mutation;drug development;Drug Targeting;Endometrial;endometriosis;Excision;experience;FDA approved;Female;Gene Modified;Genetic;Goals;Greater sac of peritoneum;Growth;Gynecologic;Hormonal;hormone therapy;Hormones;Human;Immune;Immunology;Impairment;In Vitro;in vivo;Inflammation;Inflammation Mediators;Inflammatory;Knowledge;Laboratory Research;Leadership;Lesion;lipid mediator;Macrophage;Measures;Mechanics;Medical;Mentors;Mentorship;Migraine;migration;monocyte;mouse model;Mus;Neuroimmune;Neurosciences;Nociceptors;non-opioid analgesic;Non-Steroidal Anti-Inflammatory Agents;novel;Omentum;Opiate Addiction;Opioid;opioid overdose;Pain;Pain management;pain reduction;Patients;Persons;Pharmaceutical Preparations;Pharmacology;Phase;Phenotype;Population;Process;programs;RAMP1;Reaction;recruit;reproductive;Research;Research Personnel;Resolution;Role;side effect;Signal Pathway;Signal Transduction;single-cell RNA sequencing;skills;spontaneous pain;Therapeutic;Time;transcriptome sequencing;Transgenic Mice;Treatment Effectiveness;Uterus;Work;Writing

PROJECT_TITLE: Neuroimmune communication as a driver of lesion formation and macrophage colonization of the omentum in endometriosis-associated pain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-B (55)]