NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Down Syndrome;Genetics;Heart Disease;Human Genome;Intellectual and Developmental Disabilities (IDD);Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

PHR: PROJECT NARRATIVE Valvuloseptal defects account for the majority of congenital heart defects, which are the most common human birth defect. Down Syndrome, involving trisomy of chromosome 21 affects 1 in 700 live births and causes valvuloseptal heart defects. We will investigate the molecular mechanisms that cause valvuloseptal defects in mouse and human models, including models of Down Syndrome, to understand the sets of genes that when improperly regulated cause syndromic and non-syndromic heart defects.

PI_NAMEs: SRIVASTAVA, DEEPAK  (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: Affect;Alleles;Atlases;atrioventricular septal defect;BACH1 gene;Candidate Disease Gene;candidate selection;Cardiac;cardiogenesis;Cell Line;cell type;Cells;Child;Chromatin;Chromosome 21;cofactor;Congenital Abnormality;congenital heart abnormality;Congenital Heart Defects;CRISPR interference;CRISPR screen;CRISPR-mediated transcriptional activation;Data;Defect;Dependence;Development;DNA;dosage;Dose;Down's Syndrome;Embryonic Development;Endocardium;Engineering;Epigenetic Process;epigenomics;Excision;Extracellular Matrix;Funding;Future;Gene Expression Profile;Gene Mutation;Genes;Genetic;Genetic study;Genetic Transcription;Genetic Variation;Genomics;Guide RNA;Heart;heart defect;Heterogeneity;HMGN1 gene;Human;human induced pluripotent stem cells;human model;in vivo;Individual;induced pluripotent stem cell;insight;Invaded;Live Birth;loss of function;Machine Learning;Mesenchymal;Modeling;Molecular;mouse model;Mus;Mutation;Myocardial;Myocardium;Patau's syndrome;Process;septal defect;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;System;Testing;Time;transcription factor;Transcription Repressor;transcriptome;Trisomy

PROJECT_TITLE: Cardiogenesis: Molecular Mechanisms

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: STANFORD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_FIPS: US

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Alzheimer’s disease (AD) and related dementia are a leading cause of death and disability in the aging population, affecting approximately 6.2 million people aged 65 and older each year in the United States alone. The ability to non-invasively detect the earliest changes in AD progression is a critical and unmet need that will help advance the treatment time window for the most effective interventions. This project aims to develop a novel Magnetic Resonance Imaging (MRI) approach to probe brain microstructural changes as an early marker of AD progression, which will further provide new insights into AD pathogenesis and lead to timely intervention strategies to prevent and/or slow down AD onset and/or progression.

PI_NAMEs: DAI, ERPENG  (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: 3-Dimensional;Address;Affect;Aging;aging population;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Amyloid beta-Protein;Behavior;Biological Markers;Biometry;Brain;Brain Diseases;Brain imaging;Brain Injuries;brain tissue;brain volume;Cause of Death;Clinical;clinical diagnosis;Clinical effectiveness;cognitive neuroscience;Complex;cost;Deposition;design;Detection;Diffusion;Diffusion Magnetic Resonance Imaging;Dimensions;disability;Disease Progression;early detection biomarkers;Early Diagnosis;Early identification;effective intervention;efficacy evaluation;Engineering;extracellular;Foundations;Future;Goals;gray matter;human old age (65+);image processing;imaging approach;imaging modality;improved;innovation;insight;Institution;Intervention;Ionizing radiation;Joints;Longitudinal Studies;Magnetic Resonance Imaging;Maps;Measurement;Measures;medial temporal lobe;Mentors;Mentorship;Methods;Microscopic;Mission;Modeling;molecular marker;Morphologic artifacts;Morphology;Motion;multidisciplinary;multimodal neuroimaging;multimodality;Nervous System Disorder;Neurodegenerative Disorders;neuroimaging;Neurologist;neuron loss;Neuronal Dysfunction;Neuronal Injury;Neuropsychological Tests;Neurosciences Research;Non-Invasive Detection;novel;Onset of illness;Outcome;Pathogenesis;Pathway interactions;Persons;Physics;Pilot Projects;Plasma;Play;Positioning Attribute;Positron-Emission Tomography;pre-clinical;prevent;Procedures;programs;Protocols documentation;Psyche structure;radiation effect;recruit;Research Personnel;Resolution;Risk;Role;Senile Plaques;Sensitivity and Specificity;Shapes;Source;Specificity;Structure;Symptoms;tau aggregation;tau Proteins;Techniques;Testing;Time;tool;Training;Translating;United States;Visualization;Water;white matter;Work

PROJECT_TITLE: Developing advanced diffusion MRI for early detection of Alzheimer's disease

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


ADMINISTERING_IC: EY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Cerebrovascular;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: AUGUSTA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE This proposal seeks to develop a new molecular strategy to create a favorable retinal environment for cell survival, vascular repair and revascularization of ischemic retina in retinopathy of prematurity (ROP). Sigma 1 receptor, a unique pluripotent cell survival protein, shows a novel promising vascular protection, providing a bi-functional (vascular and neuronal) therapeutic potential for ROP. The proposed studies are designed to use Sig1R deficient cells and mice to evaluate its retinal cell-type specific role, particularly vascular-immune interactive effects in rescuing neurovascular injury characteristic of ROP and to define the underlying mechanisms.

PI_NAMEs: WANG, JING  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Acceleration;Affect;Automobile Driving;bevacizumab;Blindness;Blood Vessels;cell injury;Cell Proliferation;Cell Survival;cell type;Cells;Characteristics;Childhood;Clinical;Coculture Techniques;conditional knockout;Contrast Sensitivity;Data;design;Deterioration;Development;Diabetic Retinopathy;Disease;Drops;Electroretinography;Elements;Endothelial Cells;Environment;Functional disorder;Glaucoma;glial activation;Gliosis;Goals;Hypoxia;Immune;Impairment;improved;In Vitro;in vivo;Inflammation;Inflammatory;Ischemia;knock-down;Knock-out;Knockout Mice;laser photocoagulation;Ligands;LoxP-flanked allele;Macrophage;Mediating;Microglia;Modeling;Molecular;Molecular Chaperones;Mus;Myelogenous;neovascularization;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;Neurons;neuroprotection;neurovascular;neurovascular injury;normoxia;novel;novel strategies;novel therapeutics;Oxidative Stress;Oxygen;Pentazocine;Peripheral;Photoreceptors;Physiological;Play;postnatal;Proteins;Receptor Activation;repaired;Research;response;Retina;Retinal Diseases;Retinal Ganglion Cells;retinal ischemia;Retinal Neovascularization;retinal neuron;Retinal Photoreceptors;Retinitis Pigmentosa;Retinopathy of Prematurity;revascularization;Role;Shapes;sigma-1 receptor;spheroids;standard of care;Structure;Testing;Therapeutic;Vascular Diseases;Vascular Endothelial Cell;vascular injury;Vertebrate Photoreceptors;Vision;Visual Acuity;Visual impairment;Wild Type Mouse

PROJECT_TITLE: Targeting Sigma 1 receptor as a novel therapy for limiting neurovascular injury in ROP

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project narrative Flask-shaped structures found on the surface of many types of cells known as caveolae are important regulators of human physiology. Despite this, we lack a clear understanding of how caveolae are assembled and function at a cellular level, or how defects in caveolae contribute to disease. Our proposed studies will exploit our recently determined three-dimensional structure of the major structural protein of caveolae to answer these questions using a combination of computational and experimental approaches.

PI_NAMEs: KENWORTHY, ANNE K (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Address;Binding;Biochemical;Biochemistry;Biogenesis;Biological;Body System;Cardiovascular Diseases;Caveolae;caveolin 1;Caveolins;Cell membrane;Cell Physiology;cell type;Cells;Cellular biology;Complement;Complex;Computer Analysis;Cryoelectron Microscopy;Cytoplasm;Defect;density;design;Development;Disease;Electron Microscopy;Elements;Ensure;Evolution;Face;Family;flasks;Gene Family;Genetic;Human;In Vitro;insight;Integral Membrane Protein;Knowledge;Link;Lipids;Lipodystrophy;Malignant Neoplasms;Maps;member;Membrane;Membrane Proteins;Modeling;mouse model;Mutation;Organism;particle;Pathogenicity;Physiological;Physiological Processes;Physiology;Play;Predisposition;Process;Property;Protein Family;protein function;protein structure;Proteins;Protomer;Recording of previous events;Refractory;Resolution;Role;Rotation;Series;Shapes;Sister;Structural Protein;Structure;success;Surface;Testing;three dimensional structure;Variant;Vertebrates

PROJECT_TITLE: Structural Diversity of Caveolins

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Infectious Diseases;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: Chicago

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Our study addresses a major gap by generating new knowledge on a previously less understood protein that directly contributes to corneal blindness, and in some cases, fatal outcome of a herpesvirus infection. We propose to study heparanase, a cellular protein that drives cellular inflammation during herpes infection.

PI_NAMEs: SHUKLA, DEEPAK  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Address;Adverse effects;Alzheimer's Disease;angiogenesis;Anti-viral Agents;Binding;Biological Assay;Blindness;Cause of Death;Cell Death;Cells;Complex;Cornea;Corneal Diseases;corneal epithelium;Cyclic AMP-Dependent Protein Kinases;cytokine;Cytoprotection;Data;Disease;DNA Damage;DNA Repair;Encephalitis;Environment;Epithelial Cells;experimental study;Extracellular Matrix;Eye;Eye diseases;Eye Infections;Fatal Outcome;Funding;Genetic Transcription;Genotype;Growth Factor;heparanase;Heparitin Sulfate;Herpesviridae Infections;Herpesvirus 1;Herpetic Keratitis;Human;Immunoprecipitation;Impairment;In Vitro;in vivo;in vivo evaluation;Incidence;Infection;Inflammation;Inflammatory;inhibitor;Investigation;knock-down;Knowledge;Mediating;metabolomics;mimicry;mouse model;Multiple Sclerosis;Mus;neovascularization;nerve damage;Nervous System;Neurodegenerative Disorders;new therapeutic target;Ocular Pathology;Pathology;Pathway interactions;Phenocopy;Phenotype;Phosphorylation;Phosphotransferases;Production;Prognosis;Protein Isoforms;Protein Kinase;Proteins;Proteomics;Proto-Oncogene Proteins c-akt;Publishing;Role;Severities;Severity of illness;small molecule;Testing;Time;Tissues;transcriptomics;Ulcer;Up-Regulation;Vascular Permeabilities;Viral;Viral Encephalitis;Viral load measurement;Viral Pathogenesis;Virulence Factors;Virus;Virus Replication

PROJECT_TITLE: HPSE in Ocular Herpes Infection


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Genetics;Immunotherapy;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Studies on T cell development provide direct insights into the pathophysiology of a wide variety of diseases, such as malignancies, immunodeficiency disorders, and autoimmune diseases. However, our understanding of the epigenetic regulation of lymphoid development, especially the T cell fate commitment from hematopoietic stem and progenitor cells (HSPCs), is incomplete. The goal of this project is to discover key epigenetic regulatory mechanisms underlying T cell development and explore new strategies to facilitate stem cell-based adoptive T cell therapy.

PI_NAMEs: JING, RAN  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Adoptive Cell Transfers;Affect;ATAC-seq;Autoimmune Diseases;Blood Cells;CD34 gene;Cell Maturation;Cell Surface Receptors;cell type;Cells;Cellular immunotherapy;Chromatin;Chromatin Structure;clinically relevant;Complex;Development;Developmental Process;Disease;Enzymes;Epigenetic Process;epigenetic regulation;Fostering;Functional disorder;G9a histone methyltransferase;Gene Expression Profile;Generations;Goals;Hematopoietic stem cells;Human;human induced pluripotent stem cells;human pluripotent stem cell;Immune;Immunity;Immunologic Deficiency Syndromes;Immunotherapy;improved;In Vitro;induced pluripotent stem cell;insight;K-Series Research Career Programs;laboratory development;Lymphocyte;Lymphoid;Lymphoid Cell;Lymphopoiesis;Malignant Neoplasms;Mature T-Lymphocyte;Mediating;Modeling;Modification;Molecular;mouse model;Mus;novel;Pathway interactions;Play;Production;Protein Secretion;protocol development;Protocols documentation;PTPRC gene;Research Personnel;Role;skills;small molecule;small molecule libraries;Specific qualifier value;stem cells;success;System;T cell differentiation;T cell therapy;T-Cell Development;T-Lymphocyte;Testing;Therapeutic;transcription factor;transcriptome sequencing;Zebrafish

PROJECT_TITLE: Identification of Novel Epigenetic Regulators of lymphocyte Development

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(MA)]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences;Prevention;Rare Diseases;Usher Syndrome

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Mutations in the Clarin-1 (CLRN1) gene cause Usher syndrome type 3 (USH3), a devastating orphan disease leading to combined blindness and deafness in humans. There is no treatment currently available to prevent vision loss and patients are legally blind by the fourth decade of life. This project uses newly developed pig and zebrafish models of USH3 to provide fundamental knowledge on USH3 disease pathology, and accelerate the development and validation of treatments to prevent blindness.

PI_NAMEs: DINCULESCU, ASTRA  (contact);LINK, BRIAN A;MCCALL, MAUREEN A

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Acceleration;Address;adeno-associated viral vector;Adhesions;Affect;Age;age related;Alleles;Animal Model;Apical;Auditory;Automobile Driving;autosome;biological adaptation to stress;Biological Process;Biology;Blindness;cell type;Cells;Cellular Stress;Clarin-1;clinically relevant;Cochlea;Code;cohort;Complex;Cytoskeleton;Data;deaf;Deafblind;deafness;Defect;design;Development;Disease;Early identification;Electroretinography;Event;Exons;experimental study;Eye;Family suidae;Functional disorder;Gene Modified;Genes;Hair;Hair Cells;Heterozygote;Human;Immunofluorescence Immunologic;in vivo;Inherited;insertion/deletion mutation;Knowledge;Legal Blindness;legally blind;Life;Link;Mechanical Stress;Messenger RNA;Modeling;Molecular;Molecular Probes;Morphology;Muller's cell;Mus;mutant;Mutation;nonhuman primate;Nonsense Codon;novel;Optical Coherence Tomography;Outer Limiting Membrane;Pathologic;Pathology;Patients;Phenotype;photoreceptor degeneration;Photoreceptors;Phylogenetic Analysis;Physiology;Predisposition;prevent;Process;Proteins;Publishing;Rare Diseases;Reporting;Research;Research Personnel;Retina;Retinal Cone;Retinal Diseases;retinal progenitor cell;retinal rods;Role;scaffold;selective expression;Series;Severities;Signal Pathway;single-cell RNA sequencing;Specificity;Structure;Syndrome;Testing;Therapeutic;therapy development;transcriptomics;translational therapeutics;Transmission Electron Microscopy;Usher Proteins;Usher Syndrome;Usher Syndrome Type 3;Validation;Vertebrate Photoreceptors;Zebrafish

PROJECT_TITLE: CLARIN 1 RETINAL FUNCTION AND THERAPEUTIC IMPLICATIONS FOR USH3

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-F(02)M]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Women's Health Research

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE  This research will apply and compare machine-learning methods to derive plasma proteomic signatures of physical activity and examine them in relation to ADRD, yielding insight into the molecular mechanisms and biological processes through which physical activity may delay or prevent ADRD. This research may result in proteomic biomarkers of physical activity that measure the effect of physical activity to delay or prevent ADRD and suggest potential proteomic intervention targets.

PI_NAMEs: NGUYEN, STEVE  (contact)

PROJECT_TERMS: Accelerometer;adjudication;Adult;age acceleration;Aging;aging clocks;aging related;Alzheimer disease prevention;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid beta-42;Atherosclerosis Risk in Communities;Biological;Biological Markers;Biological Process;Black race;Brain;cardiovascular health;clinically relevant;cognitive function;cognitive testing;cohort;Data;Dementia;dementia risk;Disease;Disease Outcome;Engineering;Environment;ethnic diversity;Etiology;follow-up;Funding;Glial Fibrillary Acidic Protein;Goals;Health;Hispanic;Impaired cognition;insight;Intervention;Latina;Light;Link;Long-Term Effects;Machine Learning;machine learning method;Measures;Mediating;Medicine;Memory;men;Mentorship;mild cognitive impairment;moderate-to-vigorous physical activity;Molecular;Molecular Profiling;mortality;multiple chronic conditions;neurofilament;neuropathology;novel;older women;Outcome;Pathway interactions;Patient Self-Report;Phase;Phenotype;Physical activity;Plasma;Plasma Proteins;prevent;programs;prospective;Proteins;Proteome;proteomic signature;Proteomics;racial diversity;Research;Resources;Risk;Role;Sampling Studies;Strategic Planning;tau-1;Threonine;Training;United States National Academy of Sciences;United States National Institutes of Health;vigorous intensity;White Women;Woman;Women's Health;Women's study

PROJECT_TITLE: Plasma proteomic signatures of physical activity and Alzheimer's disease and related dementias


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Hematology

ORG_CITY: NEW YORK

ORG_DEPT: BIOLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative Platelets are blood elements that are important in stopping bleeding, but they also contribute to the development of blood clots leading to heart attacks and strokes. Platelets stabilize clots by pulling them together by a mechanism termed clot retraction. The proposed studies will study how platelets produce clot retraction with the goal of obtaining information that may lead to the development of new drugs to treat or prevent heart attacks or strokes.

PI_NAMEs: BUITRAGO, CLAUDIA LORENA (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: abciximab;Actins;Adhesions;Adult;Affinity;African American population;Agonist;Amino Acid Sequence;antagonist;Applications Grants;Avidity;Award;Binding;Binding Sites;Biochemical;Biological Assay;Blood coagulation;Blood Platelets;Cardiovascular Diseases;Cause of Death;Characteristics;Charge;Chemicals;clinically relevant;Clot retraction;Coagulation Process;Collaborations;Collagen;Communities;Complex;Coronary Thrombosis;COVID-19 pandemic;crosslink;Cryoelectron Microscopy;Cytoskeleton;Data Reporting;Death Rate;Development;Diabetes Mellitus;Elements;Environment;Equipment;Equity;Fab Immunoglobulins;FDA approved;Fibrin;Fibrin fragment D;Fibrinogen;Generations;Goals;Health;Hemorrhage;Hemostatic function;high throughput screening;Hispanic Populations;Hospitals;Human;Human Biology;imaging approach;Immunization;improved;indexing;inhibiting antibody;inhibitor;insight;Integrins;Knowledge;Laboratories;lectures;Link;Maps;Mediating;Mentors;Methods;microscopic imaging;miniaturize;Minority Groups;Molecular;Molecular Target;Monitor;Monoclonal Antibodies;mortality;murine monoclonal antibody;Myocardial Infarction;novel;novel therapeutics;Obesity;Parents;Peptides;Persons;Pharmaceutical Preparations;phase 3 study;physical inactivity;Platelet aggregation;platelet function;Play;polymerization;Polymers;prevent;Process;protein complex;Proteomics;receptor;Research;Research Proposals;Resources;response;Risk;Role;role model;Scientist;Senior Scientist;Series;Signal Pathway;Signal Transduction;Stroke;Structure-Activity Relationship;symposium;Techniques;Testing;Thrombin Receptor;Thrombosis;Thrombus;tool;Training;Training and Education;Translational Research;Underrepresented Minority;United States;Universities;Woman

PROJECT_TITLE: Dissecting the Mechanims of Platelet-Fibrin interaction


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE Currently, Alzheimer’s Disease (AD) is irreversible and becoming a large and growing public health crisis with over 6.5 million Americans affected, costing over $320 billion per year for AD and related dementias (AD/ADRD). New intervention strategies targeting brain metabolism are emerging to treat and/or prevent AD, thus, it is critical to develop a robust precision mapping of cortical and subcortical brain metabolic signatures to identify altered metabolic processes and brain dysfunction associated with AD pathology, with the use of state- of-the-art high-resolution whole-brain metabolic imaging techniques with enhanced sensitivity that can detect aberrant brain metabolism and evaluate the efficacy of new interventions. This project will also generate population-based metabolic atlases of the aging population, which will enable us to identify patterns of regional metabolic abnormalities and the effect of treatment strategies targeting metabolic processes to prevent or treat AD/ADRD as well as a variety of neurological disorders.

PI_NAMEs: LEE, PHIL  (contact);VAN DER KOUWE, ANDRE JAN WILLEM

PROJECT_TERMS: 3-Dimensional;Address;Adopted;Affect;age-related disease;Aging;aging population;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease test;American;Amyloid;Amyloid beta-Protein;Anatomy;Area;Assessment tool;Atlases;Attention;Bioenergetics;Biological;Brain;brain dysfunction;brain metabolism;Brain region;brain volume;Caring;Categories;Cerebral cortex;Cessation of life;Clinical;Clinical Research;Clinical Trials;Cognitive;cognitive function;cohort;Collaborations;Consensus;cortex mapping;cost;Data;data acquisition;Data Analyses;design;Development;Disease;Disease Progression;efficacy evaluation;Energy Metabolism;Evaluation;Fright;Future;Genetic;Health Care Costs;Healthcare Systems;Heart Diseases;imaging approach;Imaging Techniques;Impaired cognition;improved;Inflammation;interest;Intervention;intervention effect;Investigation;Link;Lipids;magnetic field;Magnetic Resonance;Magnetic Resonance Imaging;magnetic resonance spectroscopic imaging;Malignant Neoplasms;Maps;Measurement;Measures;Medicine;Metabolic;Metabolic dysfunction;metabolic imaging;Metabolism;Methods;mitochondrial dysfunction;Molecular;Monitor;Morphologic artifacts;Morphology;Motion;Movement;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neuroimaging;normal aging;novel;novel therapeutic intervention;older adult;Outcome;Oxidative Stress;Pathologic;Pattern;Persons;pharmacologic;Population;population based;Positioning Attribute;Positron-Emission Tomography;prevent;Prevention strategy;prospective;Public Health;Recommendation;Registries;Research;Resolution;Resources;Scalp structure;Scanning;Signal Transduction;spectroscopic imaging;Stroke;Surface;System;Techniques;Time;Tissues;tool;treatment effect;treatment strategy;United States National Institutes of Health;Work

PROJECT_TITLE: Robust Precision Mapping of Cortical and Subcortical Brain Metabolic Signatures in AD

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Kidney Disease;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Transplantation

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE Our long-term goal is to eliminate racial disparities in chronic kidney disease progression, treatment, and care among patients within Emory Healthcare, the state’s largest healthcare system, by developing a model of care that can be replicated and sustained within health systems across the country. In the development, implementation, evaluation, and dissemination of multi-component, multi-level interventions that mitigate the impact of structural racism on healthcare delivery we will rely heavily on a community-engaged approach at all stages of implementation to maximize the impact of these interventions on patients, providers, and treatment settings. Doing so is expected to have an important positive impact on the field of public health and the mission of NIDDK through the generation of health, organizational, and implementation outcomes.

PI_NAMEs: ARRIOLA, KIMBERLY RUTH JACOB (contact)

PROGRAM_OFFICER_NAME: NORTON, JENNIFER MICHELLE

PROJECT_TERMS: acute care;Address;African American;African American population;Allografting;anti-racism;Attention;Automobile Driving;black patient;Black race;care outcomes;Caring;chronic care model;Chronic Disease;Chronic Kidney Failure;Client satisfaction;Clinical;Collaborations;community advisory board;community engaged approach;Country;design;Development;Dialysis procedure;disease disparity;Disease Progression;Disparity;Donor person;effectiveness evaluation;Effectiveness of Interventions;Elements;Employment;Environment;Equity;Evaluation;Failure;Generations;Goals;Health;health care delivery;health care settings;health equity;health organization;Health Services Accessibility;Health Status;Health system;Healthcare;Healthcare Systems;Home Hemodialysis;implementation evaluation;implementation outcomes;Improve Access;improved;Income;Inequity;innovation;interest;Interruption;Intervention;Kidney;Knowledge;lens;Link;Mission;Modeling;multi-component intervention;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;Organ Preservation;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Physicians;Population;Primary Care;primary outcome;Productivity;Provider;Public Health;Public Health Applications Research;Quality of life;Quasi-experiment;Race;racial disparity;racism;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;response;Role;Science;Series;Site;social determinants;social health determinants;Structural Racism;Structure;System;Time;Transplantation;Treatment outcome;uptake;Work

PROJECT_TITLE: Mitigating the Effects of Structural Racism on Chronic Kidney Disease Disparities among African Americans


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Prevention;Primary Health Care

ORG_CITY: LUND

ORG_COUNTRY: SWEDEN

ORG_FIPS: SW

ORG_NAME: LUNDS UNIVERSITET

PHR: NARRATIVE Recent major breakthroughs have allowed researchers to use a simple blood test to accurately determine whether a person has Alzheimer's disease, but this method needs to be tested in real-life clinical settings before it can be widely adopted. We will administer these blood tests in two real-life clinical settings (a memory clinic and a general primary care sample, 800 people each) and test i) how well the blood tests diagnose Alzheimer's compared to existing expensive and invasive tools; ii) whether patient management changes based on the blood test results; and iii) whether we can use blood tests and brief cognitive digital tests to predict who will show future cognitive decline. At the end of this project, we expect that our results will allow us and – importantly – others to implement these Alzheimer's disease blood tests in real-life clinical settings worldwide.

PI_NAMEs: PALMQVIST, SEBASTIAN  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Adopted;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease blood test;Alzheimer's disease diagnosis;Alzheimer's disease diagnostic;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease therapy;Alzheimer’s disease biomarker;authority;Biological Assay;Biological Markers;Blood;Blood Tests;blood-based biomarker;Brain;care systems;Caregivers;Caring;Cellular Phone;Cerebrospinal Fluid;Clinic;Clinical;clinical diagnostics;clinical implementation;clinical practice;Cognitive;cognitive testing;comorbidity;Consensus;cost effective;Country;Dementia;Development;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic algorithm;Diagnostic Procedure;digital;Disease;Disease Marker;Evaluation;experience;Future;Goals;Healthcare;Hematological Disease;Immunoassay;Impaired cognition;improved;Individual;informant;Infrastructure;International;Intervention;Interview;Life;Magnetic Resonance Imaging;Mass Spectrum Analysis;Measures;Memory;Memory impairment;Methods;mild cognitive impairment;Neurobehavioral Manifestations;Neuropsychological Tests;novel;novel diagnostics;novel marker;Outcome;Paper;Patient Care;patient prognosis;Patients;Persons;Physicians;Plasma;Population;Positron-Emission Tomography;Primary Care;primary care setting;prognostic;prognostic algorithm;prognostic tool;prospective;Prospective Studies;Protocols documentation;Publishing;Recommendation;recruit;Reference Standards;Research;Research Personnel;Sampling;Specialist;speech recognition;Sweden;Tablets;Test Result;Testing;Time;tool;treatment as usual;Validation;Visit

PROJECT_TITLE: Prospective validation and implementation of high-performing blood biomarkers and digital cognitive tests for detection of Alzheimer's disease in specialist memory clinic and primary care settings


NIH_SPENDING_CATS: Atherosclerosis;Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE People with HIV have a heightened coronary artery disease (CAD) risk even after controlling for traditional cardiovascular (CV) risk factors. The proposed study will assess the unique relation of coronary inflammation, measured as pericoronary adipose tissue density on cardiac computed tomography (CT), to coronary plaque development in relationship to other CAD risk factors, the effects of statins on coronary inflammation in relation to changes in plaque volume, and the relationship to major adverse CV events. We will accomplish our objectives by leveraging data from the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE) CT mechanistic substudy.

PI_NAMEs: FOLDYNA, BOREK  (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: Acceleration;Address;Adipose tissue;adverse event risk;arm;Arterial Fatty Streak;atherogenesis;Atherosclerosis;Biological Markers;Blood Vessels;Cardiac;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Characteristics;cohort;Coronary;Coronary Arteriosclerosis;Coronary artery;coronary plaque;cytokine;Data;density;Development;disorder risk;Distal;Etiology;Event;Fatty acid glycerol esters;fluorodeoxyglucose positron emission tomography;Functional Imaging;General Population;Grant;histological studies;HIV;HIV Infections;Immune;immune activation;improved;indexing;Inflammation;Inflammatory;inflammatory marker;inflammatory milieu;Investments;Measurement;Measures;Mediating;Mediation;Natural History;novel;Participant;Pathogenesis;Patients;Persons;Phenotype;Placebos;Population;Prevalence;prevent;Prevention trial;Randomized;randomized trial;Risk Assessment;Risk Factors;Risk Reduction;risk stratification;Role;Site;Time;treatment trial;trial design;uptake;vascular inflammation;Work;X-Ray Computed Tomography

PROJECT_TITLE: Pericoronary adipose tissue density a novel CT-derived marker of local inflammation and coronary artery disease in people living with HIV

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Metabolic reprogramming is required in colorectal cancer to maintain cellular plasticity and to thrive in the anoxic lumen. There is a strong body of research that coordinated inter-organellar interactions of endoplasmic reticulum-mitochondria are essential for compartmentalized metabolism. The proposed research will fill a major gap in the fundamental understanding of the mechanisms in which endoplasmic reticulum-mitochondria drive colon cancer metabolism and cell fate dynamics.

PI_NAMEs: CHEN, BRANDON  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Anabolism;Automobile Driving;Bioenergetics;cancer cell;Cancer Etiology;career;career development;Cell Differentiation process;Cell Survival;Cells;Cessation of life;Coenzymes;colon cancer cell line;colon cancer patients;Colon Carcinoma;Colonic Neoplasms;Colorectal Cancer;colorectal cancer progression;Colorectal Neoplasms;Common Neoplasm;Communication;complex IV;CRISPR screen;Data;Development;Electron Microscopy;Electron Transport;Electron Transport Complex III;Electrons;Endoplasmic Reticulum;Enzymes;Epithelium;Fellowship;Foundations;Genetic;Genetic Screening;Genetically Engineered Mouse;genome-wide;Goals;graduate school;Homeostasis;Hypoxia;Image;improved outcome;In Vitro;in vivo;in vivo Model;inducible Cre;innovation;Intestines;Ions;Knowledge;knowledge base;lipid biosynthesis;lipidomics;Lipids;Maintenance;Malignant Neoplasms;Mentorship;Metabolic;metabolic fitness;Metabolic Pathway;Metabolism;metabolomics;Metaplasia;Methods;Mitochondria;Modeling;Molecular;Monitor;mouse model;Mus;neoplastic cell;new therapeutic target;novel;novel therapeutics;Organelles;Organoids;oxidation;Oxidation-Reduction;Oxidative Phosphorylation;Pathway interactions;Patients;pharmacologic;Phase;Postdoctoral Fellow;Pre-Clinical Model;pressure;Principal Investigator;Process;Proliferating;Pyrimidine;Reaction;Regulation;Reporter;Repression;Research;Research Personnel;Research Proposals;Respiration;response;Role;Sampling;Scanning Electron Microscopy;Science;Shapes;Site;stem cell expansion;stem cells;Sterols;Stimulus;stressor;System;Therapeutic;Training;treatment response;tumor;tumor growth;tumor hypoxia;tumor metabolism;tumor microenvironment;tumor progression;Ubiquinone;Work

PROJECT_TITLE: Inter-organellar communication in metabolic reprogramming of colorectal cancer


NIH_SPENDING_CATS: Aging;Autoimmune Disease;Clinical Research;Digestive Diseases;Inflammatory Bowel Disease;Patient Safety

PHR: PROJECT NARRATIVE Despite >25% of Americans with inflammatory bowel diseases (IBD) being ≥65 years, <1% are included in clinical trials of IBD medications, resulting in a lack of robust data on safety and efficacy of these medications in older adults. Immunosuppression, associated with substantial risks and benefits that may be amplified at older ages, is the mainstay of modern IBD treatment; however, we have no tools to tailor treatments for older adults. This proposal seeks to study the impact of geriatric constructs of frailty and function as adverse event risk mediators after immunosuppressive treatments for IBD and generate a risk prediction model that can expand treatment options for the heterogeneous population of older adults with IBD.

PI_NAMEs: KOCHAR, BHARATI  (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Address;Adult;Adverse effects;Adverse event;adverse event risk;adverse outcome;Advisory Committees;Aftercare;Age;age group;Aging;American;Award;Benefits and Risks;cancer epidemiology;Cardiovascular system;career development;Caring;Categories;Chronic Disease;Chronology;clinical practice;Clinical Trials;cohort;Colon Carcinoma;comorbidity;Cox Models;Data;Decision Aid;Derivation procedure;design;Diagnosis;Discrimination;Effectiveness;Elderly;Electronic Health Record;Event;experience;Foundations;frailty;Funding;Future;Gastroenterologist;Gastroenterology;Geriatrics;Goals;Hospitalization;human old age (65+);Immunosuppression;Immunosuppressive Agents;improved;indexing;individualized medicine;Infection;infection risk;Inflammatory;Inflammatory Bowel Diseases;International;Investigation;K-Series Research Career Programs;leadership development;Learning;Measures;Mediator;Mentors;Mentorship;Modeling;Modernization;mortality;novel;older adult;Older Population;Online Systems;Operative Surgical Procedures;Outcome;Pathway interactions;patient population;Patient Self-Report;Patients;Perception;Pharmaceutical Preparations;Phenotype;Physicians;Population Heterogeneity;Positioning Attribute;predictive modeling;primary outcome;programs;prospective;Prospective cohort;Research;Research Personnel;response;Retrospective Studies;Risk;risk prediction model;risk stratification;Safety;shared decision making;Steroids;Structure;Testing;Therapeutic;Therapeutic immunosuppression;thrombotic;Time;tool;Training;treatment risk;Validation;validation studies;Work;Workplace;young adult

PROJECT_TITLE: Incorporating Geriatric Constructs into Management of Inflammatory Bowel Diseases in Older Adults


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Genetics;Immunotherapy;Inflammatory Bowel Disease;Microbiome

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Intestinal disorders including Crohn’s disease, ulcerative colitis, and irritable bowel syndrome are increasingly linked with aberrant commensal microbe driven inflammation. This application will investigate how the immune system recognizes and responds to commensal microbes to achieve immunological homeostasis that protects against aberrant intestinal inflammation.

PI_NAMEs: WAY, SING SING  (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Antibodies;Antigens;antimicrobial;ATAC-seq;Autoimmunity;autoinflammatory diseases;Binding;Biological;Biopsy;Bypass;Candida albicans;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell Lineage;Cells;ChIP-seq;Chromatin;Coculture Techniques;Colitis;commensal microbes;Crohn's disease;CTLA4 gene;Cytoprotection;Data;design;DNA Binding;Engineering;Enterobacteria phage P1 Cre recombinase;Epigenetic Process;experience;FOXP3 gene;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Gene Silencing;Germ-Free;gut colonization;gut inflammation;gut microbes;Homeostasis;House mice;Human;Immune;Immune system;Immune Tolerance;Immunologics;In Vitro;in vivo;Individual;inducible gene expression;Inflammation;Inflammatory;Inflammatory Bowel Diseases;insight;Interleukin-10;interleukin-10 receptor;Intestinal Diseases;Intestines;Irritable Bowel Syndrome;Knowledge;Kruppel-like transcription factors;Link;LoxP-flanked allele;Lymphoid Tissue;Mediating;Memory;mesenteric lymph node;MHC Class II Genes;Microbe;Modeling;Molecular;Mucous Membrane;Mus;novel;Onset of illness;overexpression;OX40;Pathogenesis;Peripheral;Phenotype;Physiological;Production;Property;Recombinants;reconstitution;Regulatory T-Lymphocyte;response;RNA;selective expression;single-cell RNA sequencing;Specificity;stem;T cell differentiation;T-Cell Proliferation;T-Lymphocyte;T-Lymphocyte Subsets;Tissues;Ulcerative Colitis;Zinc Fingers

PROJECT_TITLE: Kruppel-like factor-2 CD4+ T cells and intestinal inflammation

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Lung;Pulmonary Hypertension

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Pulmonary hypertension, the state of having high blood pressure in the lungs, affects more than 1.5 million U.S. adults, is more common with age, and causes significant respiratory symptoms and a higher risk of death. In a large portion of patients, pulmonary hypertension is the result of underlying chronic lung disease, and unfortunately, no direct treatment is available. This research project will evaluate metabolic abnormalities as an underlying and treatable cause of pulmonary hypertension in patients with chronic lung disease.

PI_NAMEs: TRAMMELL, AARON WAYNE (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Acute;Address;Adult;Affect;Age;Animal Model;Anti-diabetic Drugs;Apoptotic;Bioenergetics;Biology;Blood Platelets;Blood Vessels;Cardiac Myocytes;career;Caring;Chronic;Chronic lung disease;Clinical;Clinical Management;clinical phenotype;Clinical Research;clinical trial implementation;Clinical Trials;cohort;Control Groups;Cross-Over Trials;Cross-Sectional Studies;Dimensions;Disease;disorder control;disorder risk;effective therapy;Energy Metabolism;Environment;Epidemiology;experience;Exposure to;extracellular;Funding;Gender;Glucose;Goals;high risk;Human;human old age (65+);Hypertension;Hypoxia;Impairment;improved;in vivo;individual patient;innovation;Intervention;Knowledge;Lead;Lesion;Ligands;Lipids;Lung;Lung Diseases;lung hypoxia;Measures;Mentors;Mentorship;Metabolic;metabolic phenotype;Metabolism;Mitochondria;mitochondrial metabolism;Modeling;mortality risk;Nature;novel;novel strategies;Outcome;Outpatients;overtreatment;Oxygen;Participant;Pathogenesis;Pathogenicity;patient oriented;Patients;Persons;Pharmaceutical Preparations;Phase;Phenotype;Pioglitazone;Placebos;platelet phenotype;Play;Positioning Attribute;PPAR gamma;pre-clinical;Pre-Clinical Model;Predisposition;pressure;prevent;primary outcome;Production;prospective;pulmonary arterial hypertension;Pulmonary Circulation;Pulmonary Fibrosis;Pulmonary Hypertension;pulmonary vascular cells;pulmonary vascular remodeling;pulmonary vasoconstriction;Randomized;recruit;Research;Research Project Grants;Respiration;Respiratory Signs and Symptoms;response;Right ventricular structure;Role;Safety;Sampling;secondary outcome;Severities;Skeletal Muscle;Specimen;Symptoms;Testing;Therapeutic;therapeutic target;Thiazolidinediones;Time;Tissues;Training;training opportunity;Training Programs;Translating;Translational Research;translational study;Vasodilation;Vasodilator Agents;Veterans

PROJECT_TITLE: Bioenergetic impairment in Group 3 pulmonary hypertension

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research

PHR: Project Narrative The proposed study is relevant to public health because it focuses on testing a novel adapted evidence-based multilevel intervention, D-THIO: Deprescribing Thyroid Hormone In Older Adults, to support thyroid hormone deprescribing (dose de-escalation and/or discontinuation) in older adults with thyroid hormone overtreatment and/or misuse and reduce patient harm. Findings from this study will lay the groundwork for broad implementation of D-THIO and serve as a model for deprescribing inappropriate medications for other endocrine conditions and conditions with biochemical monitoring. Thus, the proposed research is relevant to the part of the NIH’s mission that pertains to de-implementing low-value care in older adults.

PI_NAMEs: PAPALEONTIOU, MARIA  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Abbreviations;Adoption;Adult;Adverse event;Advocate;aged;American;Atrial Fibrillation;Attitude;Behavior;Biochemical;Biochemical Markers;California;Canada;Cardiovascular system;Caring;Clinical;clinical practice;Computerized Medical Record;Deimplementation;Dose;Drug Prescriptions;Education;effectiveness evaluation;effectiveness/implementation trial;Endocrine;Endocrine System Diseases;Endocrinologist;evidence base;Funding Agency;Growth;Guidelines;Health system;High Prevalence;hormone therapy;Hormone use;Hypothyroidism;implementation facilitators;implementation outcomes;innovation;Intervention;Interview;Knowledge;Letters;Maintenance;Michigan;Mission;Modeling;Monitor;mortality;multi-site trial;Normal Range;novel;older adult;optimism;Osteoporosis;overtreatment;Ownership;Pamphlets;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Pilot Projects;Polypharmacy;Prevalence;Primary Care;primary outcome;process evaluation;Provider;Public Health;Quebec;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Risk;San Francisco;secondary outcome;Self Efficacy;Site;skeletal;success;Surveys;System;Testing;Thyroid Gland;Thyroid Hormones;Thyroid Nodule;Thyrotropin;Thyroxine;treatment as usual;United States;United States National Institutes of Health;Universities

PROJECT_TITLE: Optimizing Care for Older Adults through Thyroid Hormone Deprescribing

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Diabetes;Precision Medicine;Wound Healing and Care

PHR: PROJECT NARRATIVE The objective of this proposal is to establish and translate novel noninvasive imaging methods and blood markers prognostic of impaired wound healing in the setting of diabetic foot ulcers (DFU). We will benchmark the sensitivity, specificity, and repeatability of MRI-derived foot perfusion markers and systemic and local metabolic markers of poor wound healing in DFU and examine multiparametric classification models to predict wound healing outcomes in DFU patients receiving standard of care. We expect this work to provide novel information for more effective treatment strategies and lead to improved clinical management of DFU.

PI_NAMEs: REITER, DAVID A (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Address;Amputation;Anti-Inflammatory Agents;Antibiotics;Benchmarking;Bioenergetics;Blood;blood oxygen level dependent;Blood Vessels;Caring;Cell Respiration;Cells;Chronic;Classification;Clinical;clinical care;Clinical Management;clinical practice;Clinical Research;Complex;Complications of Diabetes Mellitus;cost;Diabetes Mellitus;diabetic;Diabetic Foot;Diabetic Foot Ulcer;diabetic patient;diabetic wound healing;Diagnosis;Diagnostic;effective therapy;Elasticity;Exhibits;foot;Foot Ulcer;Foundations;Funding;Glycolysis;healing;Hospital Costs;Hospitalization;Hospitals;Hyperemia;imaging modality;immunoregulation;Impaired wound healing;Impairment;improved;indexing;Inflammatory;Intervention;Ischemia;Knowledge;lifetime risk;limb loss;Limb Salvage;Liquid substance;Lower Extremity;Macrophage;macrovascular disease;Magnetic Resonance Imaging;Measurement;Measures;Mediator;Metabolic;Metabolic Marker;Metabolic Pathway;metabolomics;Methods;Microvascular Dysfunction;Modality;Modeling;monocyte;Motion;Myelogenous;Myeloid Cells;National Institute of Diabetes and Digestive and Kidney Diseases;neutrophil;Neutrophil Infiltration;non-invasive imaging;novel;Operative Surgical Procedures;Outcome;Outcome Measure;Oxygen;Pathogenesis;Patients;Perfusion;Perfusion Weighted MRI;personalized medicine;Persons;Phenotype;Pilot Projects;Plasma;predictive marker;predictive modeling;predictive tools;Procedures;prognostic;Prognostic Marker;prognostic tool;prognostication;Protocols documentation;quantitative imaging;recruit;repaired;Reproducibility;Resolution;Resources;Rest;revascularization;Risk;risk stratification;Signal Transduction;Specificity;Spirometry;standard of care;statistical learning;Stress;targeted treatment;Testing;Tissues;tool;transcriptome;transcriptomics;Translating;treatment strategy;Ulcer;United States;Work;wound;wound care;wound healing;Wound healing therapy

PROJECT_TITLE: Prognostic MRI and Blood Markers of Wound Healing in Diabetic Foot Ulcers

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: SAINT PAUL

ORG_NAME: MINNESOTA HEALTHSOLUTIONS CORPORATION

ORG_STATE: MN

PHR: Project Narrative  The rapid increase in the number of older adult drivers (OAD’s), and the overrepresentation of OAD’s in motor vehicle crashes and injuries, has heightened the need for products which improve roadway safety in this population. This phase 1 SBIR proposal focuses on the feasibility and usability of a novel driving coach app (StreetCoach) to improve driving performance in OAD’s with and without Alzheimer’s Disease (AD), Alzheimer’s Disease and Related Dementia (ADRD), and/or cognitive impairment.

PI_NAMEs: EHSANI, POUYA JOHNATHON;KRAMER, KEVIN M. (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Acceleration;Accounting;Active Learning;aged;Alzheimer's Disease;Alzheimer's disease related dementia;Automobile Driving;Awareness;Biomedical Research;Cellular Phone;Cessation of life;Clinical;Clinical Trials;Cognition;cognitive function;Collaborations;commercialization;Data;Data Collection;design;Development;Doctor of Philosophy;driving behavior;driving performance;Education;efficacy testing;experience;Fatality rate;feasibility testing;Feedback;Fostering;frailty;functional independence;Goals;Health;high risk population;Impaired cognition;improved;Incidence;Injury;innovation;Insurance;Insurance Carriers;Licensing;Measures;Methods;mid-career faculty;Minnesota;mobile application;Modality;Monitor;multidisciplinary;Notification;novel;older adult;Older Population;Persons;Phase;Physical Function;physical impairment;Population;preference;preservation;Production;prototype;Public Health Schools;Recording of previous events;Relative Risks;remediation;Research;Research Personnel;Risk;risky driving;Safety;Sampling;Self Management;skills;Small Business Innovation Research Grant;smartphone application;success;System;Technology;teen drivers;Testing;Time;tool;Universities;usability;Vehicle crash;virtual;Washington;Work

PROJECT_TITLE: A novel driving coach app for older adults with cognitive impairment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-C(10)B]


NIH_SPENDING_CATS: Aging;Genetics

PHR: PROJECT NARRATIVE Chromatin, a nuclear entity in a cell, can be abnormally shuttled to the cytoplasm during aging, leading to inflammation. This proposal studies how fragments of chromatin are shuttled from the nucleus to the cytoplasm, and how to block this pro-inflammatory process via metabolic changes. This study will offer novel insights into age-associated inflammation, with potential to develop new strategies to suppress chronic inflammation and to promote healthy aging.

PI_NAMEs: DOU, ZHIXUN  (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: age related;Age related pathologies;age-related disease;aged;Aging;aging related;anti aging;antimicrobial;Biology;Bulla;Capsid;Cell Aging;Cell Cycle Arrest;Cell Nucleus;Cell secretion;Cells;chemokine;Chromatin;Chronic;Clinical Trials;Complex;cytokine;Cytoplasm;Cytosol;Development;Disease;DNA;DNA Viruses;Down-Regulation;Electron Transport Complex III;Epigenetic Process;Event;experimental study;Genetic;Genome;Glucose;Growth Factor;hallmarks of aging;healthy aging;Hepatocyte;Herpesviridae;Immune;Immunologic Surveillance;Impairment;In Vitro;in vitro Model;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;insight;Intervention;Knowledge;Link;Liver;Measurement;Mediating;Membrane;Metabolic;Metabolism;Metformin;microbial;Microscopy;Modeling;Molecular;mouse model;Mus;new therapeutic target;novel;Nuclear;Nuclear Envelope;Nuclear Inner Membrane;Nuclear Lamina;Nuclear Outer Membrane;Nuclear Pore Complex;nutrient metabolism;old mice;Oncogenes;Oncogenic;Pathway interactions;Peptide Hydrolases;pharmacologic;Process;programs;Proteins;recruit;Reporting;Research;Role;senescence;senescence associated secretory phenotype;senescent cell;Severity of illness;Signal Transduction;Stimulator of Interferon Genes;tissue regeneration;Tissues;tool;trafficking;Viral;virology

PROJECT_TITLE: Nucleus-to-cytoplasm trafficking of chromatin fragments in senescence and aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-Z(52)]


ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: Herpes stromal keratitis (HSK) occurs due to the growth of blood vessels and accumulation of neutrophils and effector CD4 T cells in the corneal stroma of the HSV-1 infected cornea. The proposed application will study the pleiotropic effects of CXCR4 signaling in promoting the retention of immune cells and hemangiogenesis in HSK.

PI_NAMEs: SUVAS, SUSMIT  (contact)

PROJECT_TERMS: Affect;Antigen-Presenting Cells;Blindness;Blood Vessels;C57BL/6 Mouse;CD4 Positive T Lymphocytes;Cell Degranulation;cell motility;Cells;chemokine receptor;Cornea;corneal epithelium;Corneal Stroma;CXCR4 gene;Data;Dendritic Cells;Deposition;Development;effector T cell;Endothelium;Epithelium;experimental study;Flow Cytometry;functional outcomes;Growth;healing;Herpes Simplex Infections;Herpes stromal keratitis;Herpesvirus 1;Histamine;Histamine Release;Homing;Human;Immune;immune cell infiltrate;Impairment;Individual;Infection;Inflammation;Inflammatory;injured;Interferon alpha;Interferon Type II;Ischemia;Langerhans cell;langerin;Lesion;Ligands;Lipids;mast cell;Mediating;Methods;migration;monoamine;monocyte;mouse model;Mus;neovascularization;neutrophil;Neutrophil Infiltration;Pathogenicity;PECAM1 gene;Phenotype;Play;pleiotropism;Production;Protocols documentation;PTPRC gene;Recurrence;Reporting;response;RNA Viruses;Role;Severities;Signal Transduction;Standardization;Stromal Cell-Derived Factor 1;Suspensions;T-Lymphocyte;Testing;therapeutic target;Tissues;United States;Vascular Endothelial Cell;Viral Load result;Visual;Visual impairment

PROJECT_TITLE: CXCR4: A potential therapeutic target in HSK


ADMINISTERING_IC: MD

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it provides evidence on the extent to which the transportation benefit in the Medicaid program — which currently insures over 84 million low-income individuals in the United States — is associate with racial/ethnic disparities in health care access and outcomes. It will generate important information on steps state and federal policymakers can take to use the transportation benefit to improve health equity. The proposed research is relevant to NIMHD’s mission as it pertains to generating knowledge that contributes to improving minority health and reducing health disparities.

PI_NAMEs: MICHENER, JAMILA D (contact);SCHPERO, WILLIAM LEWIS

PROGRAM_OFFICER_NAME: OLADEINDE, YEWANDE A

PROJECT_TERMS: access disparities;Administrator;Affect;aged;American;beneficiary;Black race;burden of illness;care outcomes;Caring;Characteristics;Clinic;Clinical;copayment;cost;cost effective;Data;Data Set;Data Sources;design;Disabled Persons;Disparity;disparity reduction;Eligibility Determination;Ensure;Environmental Risk Factor;Equity;ethnic disparity;ethnic health disparity;ethnic minority population;Ethnic Origin;Face;federal policy;Funding;Goals;Health;health care availability;health care disparity;health care service utilization;health equity;Health Personnel;Health Services Accessibility;Heterogeneity;Hispanic;Hospitalization;Improve Access;improve minority health;improved;Individual;Infrastructure;innovation;Insurance Carriers;Intervention;Interview;Knowledge;Link;Low income;Low Income Population;low socioeconomic status;Measures;Medicaid;Medicaid eligibility;Medical;medical appointment;Medicare/Medicaid;Methodology;Minority Groups;Mission;National Institute on Minority Health and Health Disparities;Not Hispanic or Latino;novel;Outcome;patient population;Patient-Focused Outcomes;Patients;Physicians;Policies;Policy Maker;Population;Pregnant Women;Primary Care;prior authorization;Process;programs;Provider;Public Health;Qualitative Research;Quasi-experiment;Race;racial disparity;racial minority population;Reduce health disparities;Research;Research Design;Services;social health determinants;Social outcome;Structure;Testing;Translations;Transportation;transportation access;Underserved Population;United States;Variant;Vulnerable Populations;Work

PROJECT_TITLE: Racial and Ethnic Disparities in Access to the Medicaid Transportation Benefit and Implications for Patient Outcomes

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative The neocortex controls key components of perception, human cognition, and memory. Understanding the origin and function of cortical tuning and feature maps is a necessary step towards advancing our knowledge of the etiology of developmental and circuit disorders. The proposed work addresses NIH’s mission to develop funda- mental knowledge that will advance medical science and help reduce suffering and the societal burdens of cen- tral nervous system disorders.

PI_NAMEs: RINGACH, DARIO L (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Address;Animals;Architecture;area striata;Cells;Central Nervous System Diseases;Classification;Cognition;Color;cortex mapping;Cortical Column;Data;Development;Disease;Equilibrium;Etiology;Experimental Designs;experimental study;Eye Movements;Frequencies;ganglion cell;Goals;Human;Image;imaging modality;Individual;innovation;Knowledge;Link;Location;Locomotion;Mammals;Maps;Measures;Medical;Memory;Methods;Mission;Modeling;Mus;Neighborhoods;Neocortex;Neurons;Outcome;Perception;Process;receptive field;Research;response;Retinal Ganglion Cells;scaffold;Science;segregation;self organization;sex;Signal Transduction;Site;Spatial Distribution;Stimulus;Structure;Surface;Techniques;Testing;Textbooks;Thalamic structure;two-photon;United States National Institutes of Health;Vertebral column;Visual Fields;visual processing;visual stimulus;Visual System;Work

PROJECT_TITLE: Thalamic constraints on cortical organization

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Kidney Disease;Mental Health;Organ Transplantation;Racial and Ethnic Minority Health Research;Social Determinants of Health;Transplantation

ORG_CITY: CHICAGO

ORG_DEPT: SURGERY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Narrative End-stage renal disease afflicts Black persons disproportionately more than other races/ethnicity and although kidney transplantation provides the best outcomes for patients, Black patients with end-stage renal disease are less likely referred for kidney transplant evaluation, less likely listed for kidney transplantation, and less likely to receive a kidney transplantation. Structural racism is a fundamental cause of racial disparity in health outcomes for Black patients with end-stage renal disease and to this end - rooted in the Black experience - Dr. Simpson together with the Black community created the first African American Transplant Access Program {AATAP) in the country at a large transplant center in the heart of diverse Chicago. This grant proposes (i) to study the impact of AATAP on patients and transplant metrics (e.g., listing rates), (ii) to increase awareness and structural competency among transplant gatekeepers {clinicians, staff) and {iii) to demonstrate generalizability by adapting the AATAP program to another large kidney transplant program in Florida.

PI_NAMEs: KERSHAW, KIARRI N;LADNER, DANIELA P (contact);SIMPSON, DINEE C.

PROJECT_TERMS: Achievement;Affect;African American;American;Awareness;black patient;Black Populations;Black race;Caring;Cause of Death;Chicago;Chronic Disease;Cities;Communities;community engagement;Competence;cost;Country;Decision Aid;design;Diabetes Mellitus;Dialysis procedure;Discrimination;Empathy;Employment;End stage renal failure;Ethnic Origin;Evaluation;experience;Face;First Name;Florida;Food;Fright;Gatekeeping;General Hospitals;Grant;health inequalities;Health Insurance;health literacy;health related quality of life;Health system;Heart;High Prevalence;Hypertension;implicit bias;Improve Access;improved;Information Dissemination;Institution;Institutional Racism;Intervention;Interview;Kidney Diseases;Kidney Transplantation;Knowledge;Language;Length;Life Expectancy;literacy;Lived experience;maltreatment;marginalization;Medical;medical specialties;Medicine;member;Morbidity - disease rate;mortality;Neighborhoods;Nurses;Obesity;Outcome;Patient-Focused Outcomes;Patients;perceived discrimination;Perception;Persons;Pharmacy facility;Policies;Population;Procedures;Process;Process Measure;programs;Provider;Psychiatrist;Psychosocial Assessment and Care;Quality of life;Race;racial health disparity;racism;Recurrence;Resources;segregation;Self Efficacy;Social support;Social Workers;Structural Racism;Surgeon;System;Testing;Time;Training;transplant centers;Transplantation;Trust;United States;Visit;Wait Time;Waiting Lists

PROJECT_TITLE: Improving access to renal transplantation for Underserved Black Communities


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: MADISON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative  The essential human enzyme O-GlcNAc transferase (OGT) dynamically regulates a variety of physiological and pathological processes including the “Warburg effect” in cancer cells and insulin resistance in diabetes. This proposed research will elucidate how OGT interacts with other proteins, which will be essential for understanding OGT’s functional regulation in nutrient sensing and other important roles and will support the need to specifically modulate OGT functions for biomedical applications.

PI_NAMEs: JIANG, JIAOYANG  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Active Sites;Address;Affinity;Area;Binding;Binding Proteins;Binding Sites;Biochemical;Biological;Biological Assay;Biology;cancer cell;Catalytic Domain;Cells;Chemicals;Complex;Conserved Sequence;Coupled;Coupling;detection of nutrient;Development;Diabetes Mellitus;Disease;drug discovery;Enzyme Kinetics;Enzymes;experimental study;Funding;glycosylation;Human;imaging approach;In Vitro;innovation;insight;Insulin Resistance;interest;Investigation;Knowledge;Ligand Binding Domain;Link;Malignant Neoplasms;Mediating;Modification;Molecular;Molecular Conformation;mutant;Mutation;novel;Nutrient;O-GlcNAc transferase;Outcome;Pathologic Processes;Pathway interactions;Peptides;Phage Display;Physiological Processes;protein complex;Protein Glycosylation;protein protein interaction;Proteins;Proteome;Proteomics;Regulation;Research;Resolution;response;Role;Scaffolding Protein;sensor;Site;Stress;structural biology;Structure;Substrate Interaction;sugar;System;Techniques;Time;Warburg Effect

PROJECT_TITLE: Beyond the Active Site: Structure Informed Novel Regulatory Mechanisms and Functional Modulation of O-GlcNAc Transferase

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research

ORG_CITY: LAWRENCE

ORG_NAME: CONTINUUM EDUCATIONAL TECHNOLOGIES, PBC

PHR: PROJECT NARRATIVE - STARTUP CENTRAL Continuum Educational Technologies will collaborate with the University of Kansas and other Central Region IDeA State universities to develop an integrated suite of entrepreneurial education products to help university bioscience researchers commercialize their discoveries and bring critical biomedical innovations to market. Composed of a comprehensive curriculum and integrated learning management system, along with a framework for its cohort based implementation in an institutional setting, the product suite will seek to inspire, educate, train, and support academic entrepreneurs to increase both the number of opportunities for entrepreneurial commercialization of university research, as well as the likelihood that such efforts will be successful.

PI_NAMEs: COURTNEY, ADAM ;FRIIS, ELIZABETH A (contact)

PROGRAM_OFFICER_NAME: ZHOU, YANG

PROJECT_TERMS: Academic support;Acceleration;Address;Adult;Advisory Committees;Agreement;Attitude;Award;Biological Sciences;Biomedical Research;Case Study;cohort;Collaborations;Collection;commercial application;commercialization;commercialization readiness;comparison control;Competence;design;Development;Disparate;E-learning;Economic Development;Economics;Education;education resources;Educational Activities;Educational Curriculum;Educational Models;Educational Psychology;Educational Technology;Effectiveness;efficacy evaluation;efficacy testing;Entrepreneurship;Evaluation;evaluation/testing;experience;Faculty;Feedback;Goals;Growth;Health;Human;improved;Incentives;Individual;innovation;insight;Institution;Kansas;Laboratory Research;Learning;Legal patent;Licensing;Marketing;Medical;Modeling;Outcome;Participant;Phase;Pilot Projects;Preparation;Probability;Procedures;Process;programs;prototype;Research;Research Activity;Research Personnel;Resource Sharing;Resources;Running;Selection Criteria;Small Business Innovation Research Grant;Small Business Technology Transfer Research;Students;success;System;technological innovation;Technology;Testing;tool;Training;Translating;Translational Research;Translations;Universities;usability;Validation;Work

PROJECT_TITLE: STARTUP Central


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Digestive Diseases;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative  Early detection of pancreatic cancer is one of the foremost priorities of the NCI. The overarching goal of this F99/K00 proposal is to develop the capability of non-invasively detecting advanced pancreatic intraepithelial neoplasia (PanIN) precursor lesions in pancreas prior to invasive disease using two magnetic resonance imaging based tools: a) hyperpolarized metabolic imaging (HP MRI) and b) acidoCEST MRI and test the efficacy of immunoprevention in animal models employing these techniqies. The success of this proposal has the potential for leading to practice changing recommendations for non-invasively detecting and monitoring advanced PanIN lesions and incipient pancreatic cancer, as well as to prevent over-diagnosis and over-treatment in cysts that harbor indolent biology.

PI_NAMEs: ENRIQUEZ, JOSE S (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Alanine;Anatomy;Animal Model;Animals;Area;Biochemical;Biological Markers;Biology;Cancer Center;Cancer Detection;Cancer Etiology;cancer imaging;cancer prevention;cancer type;Cessation of life;chronic pancreatitis;Clinical;Contrast Media;Cyst;Data Analyses;Detection;detection method;Development;Diagnosis;Disease;Disease Progression;Doctor of Medicine;Doctor of Philosophy;Early Diagnosis;Educational process of instructing;efficacy evaluation;efficacy testing;extracellular;Fellowship;Future;Genetic Models;Genetically Engineered Mouse;Genomics;Goals;high risk;Histological Techniques;human subject;Image;imaging approach;imaging modality;imaging system;Imaging Techniques;Immunoprevention;Immunotherapy;in vivo;in vivo imaging;Indolent;Inflammation;innovation;Institution;Laboratories;Learning;Lesion;Magnetic Resonance Imaging;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Mentors;Metabolic;metabolic imaging;Metabolism;metabolomics;Methodology;Methods;Modality;Modeling;molecular imaging;Monitor;Morphology;mouse model;neoplastic;Non-Invasive Detection;non-invasive imaging;non-invasive monitor;novel;overtreatment;Pancreas;pancreatic cancer model;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pancreatic Intraepithelial Neoplasia;Pattern;Phase;Positron-Emission Tomography;Postdoctoral Fellow;pre-clinical;premalignant;Prevalence;prevent;Prevention;Prevention Measures;Prevention strategy;Production;Public Speaking;Pyruvate;Recommendation;Research;Research Project Grants;Research Proposals;Scientist;Sensitivity and Specificity;Signal Transduction;skills;specific biomarkers;Specificity;success;Survival Rate;Symptoms;Techniques;Time;Tissues;tool;Training;transcriptomics;Translating;tumor;tumor microenvironment;United States;Warburg Effect;Work;Writing

PROJECT_TITLE: Real Time Metabolic Imaging to Interrogate Early Detection and Prevention of Pancreatic Cancer


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_DEPT: NEUROLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Spinocerebellar ataxia type 1 (SCA1) is a progressive neurodegenerative disease, whereby individuals gradually develop incoordination, which progresses to being weak, short of breath, and culminating in premature death. This proposal aims to understand which brain cells are responsible for the premature death and what molecular changes within them lead up to their degeneration. Understanding these details are important for developing effective treatments for patients with SCA1.

PI_NAMEs: ORENGO, JAMES P (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Abnormal coordination;Address;Affect;Area;astrogliosis;Ataxia;Behavioral;Behavioral Assay;behavioral phenotyping;brain cell;Brain Stem;Breathing;CAG repeat;Cell Culture Techniques;Cell Nucleus;cell type;Cells;Cerebellar degeneration;Cessation of life;deep sequencing;Deglutition;Denervation;Development;Disease;Disease Progression;Dissociation;effective therapy;Electrophysiology (science);experimental study;Family;Functional disorder;Genetic Epistasis;Genetic Transcription;Goals;Health;Histology;Impairment;in vivo;Individual;inhibitor;innovation;interest;Intervention;Investigation;Investments;JUN gene;Knowledge;Lead;Life;LoxP-flanked allele;MAPK8 gene;Mediating;Modeling;Molecular;Morphology;motor neuron degeneration;Motor Neuron Disease;Motor Neurons;mouse model;mRNA sequencing;Mus;Muscle Weakness;Muscular Atrophy;N-terminal;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;Neurologic;neuron loss;neuronal cell body;Neuronal Dysfunction;Neurons;novel;novel therapeutics;Nuclear;overexpression;Pathogenicity;Pathology;Pathway interactions;Patients;Peptides;Phenotype;Phosphotransferases;Play;polyglutamine;premature;Process;Proteins;Respiration Disorders;respiratory;Respiratory Failure;response;Risk;Role;Secondary to;Shortness of Breath;Signal Transduction;Skeletal Muscle;skeletal muscle wasting;Sorting;Spinal Cord;Spinocerebellar Ataxias;Symptoms;Tissues;transcriptome sequencing;transcriptomics;Type 1 Spinocerebellar Ataxia

PROJECT_TITLE: Investigating Motor Neuron Disease in Spinocerebellar Ataxia, Type1

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Atherosclerosis;Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Heart Disease;Patient Safety

ORG_CITY: PHILADELPHIA

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE The lack of definitive evidence (prospective randomized or retrospective observational) to support (or refute) the use of intraoperative transesophageal echocardiography (TEE) during isolated coronary artery bypass graft (CABG) surgery has led to widespread practice pattern variability and a near 50/50 split in TEE (vs no TEE) intraoperatively – an evidence gap with clinical equipoise. This study aims to leverage this existing practice pattern variability and clinical equipoise to generate the required foundational data necessary to inform a future, multicenter randomized controlled trial (RCT) that could resolve questions surrounding the efficacy, effectiveness, and risk-benefit ratio of intraoperative TEE during isolated CABG surgery. These findings will be critically important for health policy efforts to reduce variability, standardize intraoperative care, and improve perioperative outcomes among cardiac surgery patients undergoing isolated CABG surgery.

PI_NAMEs: MACKAY, EMILY JANE (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Aorta;arm;Cardiac;Cardiac Surgery procedures;Clinical;clinical efficacy;Clinical Trials;comparative effectiveness;Comparative Effectiveness Research;comparative effectiveness study;Coronary Artery Bypass;Data;Decision Making;Dedications;design;Disease;Effectiveness;Enrollment;Equipoise;Foundations;Funding;Future;Goals;Health Policy;Health Services;heart imaging;Heart Valves;hemodynamics;Hospitals;Imaging Techniques;improved;improved outcome;Incidence;Injury;Institution;Intervention;Interview;Intraoperative Care;Intraoperative Complications;learning strategy;Medical center;Mentors;Mentorship;Methodology;Methods;Modification;Monitor;Multi-Institutional Clinical Trial;Multicenter Trials;Operative Surgical Procedures;Outcome;patient population;Patients;Pattern;Perioperative;Population;Postoperative Period;preference;Presbyterian Church;Procedures;prospective;Provider;Qualitative Research;Randomized;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;recruit;Research;Research Personnel;Research Training;Risk;risk/benefit ratio;Role;Sampling;satisfaction;Societies;Standardization;statistical learning;Structure;Subgroup;Surgeon;Testing;Thoracic Surgeon;Training;Transesophageal Echocardiography;treatment effect;Trees;trial comparing;ultrasound;US State;Work

PROJECT_TITLE: The Role of Intraoperative Transesophageal Echocardiography During Isolated Coronary Artery Bypass Graft Surgery


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Genetic Testing;Genetics;Human Genome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The causes of approximately half of stillbirth cases are unknown. Novel genetic analysis techniques applied in a unique data source with families and large pedigrees allow identification of previously unrecognized causes of stillbirth. The results will improve risk stratification for stillbirth, identify novel therapeutic targets, facilitate closure and bereavement for grieving families, and improve subsequent perinatal outcomes.

PI_NAMEs: WORKALEMAHU, TSEGASELASSIE  (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: adverse pregnancy outcome;Affect;Alleles;Aneuploidy;base;Benchmarking;Bereavement;Biochemical;Biological;biomarker discovery;biomarker identification;Birth;birth control;Caring;case control;causal variant;Clinical Data;clinical phenotype;Code;cohort;Couples;Data;Data Sources;de novo mutation;Development;Diagnosis;DNA;DNA analysis;DNA Library;Economics;Emotional;Etiology;exome sequencing;experience;Family;Family member;Fathers;Feeling;fetal;Fetal Death;Future;Genes;Genetic;genetic analysis;genetic disorder diagnosis;genetic pedigree;Genetic Predisposition to Disease;Genetic Research;Genetic Screening;genetic variant;Genome;genome sequencing;Genomic Segment;Germ-Line Mutation;Goals;Guilt;Haplotypes;Healthcare Systems;Heritability;Heterogeneity;high risk;Human Development;improved;Infection;Inherited;innovation;insertion/deletion mutation;insight;Institutional Review Boards;Karyotype;Link;Live Birth;loss of function;Medical;Medical Genetics;Medical Records;Mission;Molecular;Molecular Abnormality;National Institute of Child Health and Human Development;new therapeutic target;novel;obstetrical complication;offspring;Outcome;Parents;Pathogenicity;Pathway interactions;Perinatal mortality demographics;perinatal outcomes;Perinatology;Phenotype;Pilot Projects;Placenta;population based;Population Database;Pregnancy;prevent;Prevention;Probability;recruit;Recurrence;Regulatory Element;Reproductive Medicine;Resources;Rest;Risk;risk sharing;risk stratification;risk variant;Sampling;segregation;Single Nucleotide Polymorphism;stillbirth;targeted sequencing;Techniques;Technology;therapeutic target;Uncertainty;Utah;Validation;Variant;whole genome;Woman

PROJECT_TITLE: Inherited and de novo genetic variants relevant to familial, recurrent and sporadic stillbirth

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Leptin-sensitive neurons within the hypothalamus, including AgRP neurons, play a dominant role in regulating appetite, and until recently we did not have the tools needed to study the transcriptional regulatory processes that govern their activity during the development of obesity. This project will utilize cutting-edge cell-type specific genomic profiling techniques to study a newly identified transcription factor, Interferon Regulatory Factor 3 (IRF3) in leptin-sensitive neurons, including, AgRP neurons (IRF3AgRP) that is both regulated for acute leptin sensitivity and is potentially disrupted during states of hyperleptinemic diet-induced obesity. The transcriptional pathway investigated in this project will aid the discovery of novel therapeutic targets for the treatment of obesity.

PI_NAMEs: HEYWARD, FRANKIE DARRYN (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Acute;Adipocytes;Advisory Committees;Affinity Chromatography;Appetite Depressants;ATAC-seq;Body Weight;career;career development;Cell Nucleus;cell type;Cells;ChIP-seq;Chromatin;Chronic;Cleavage Under Targets and Release Using Nuclease;Data;Data Set;Desire for food;Development;diet-induced obesity;DNA Binding;Endocrinology;energy balance;Ensure;Environment;epigenomics;Exhibits;experience;experimental study;Fasting;feeding;Feeding behaviors;Foundations;Funding;gain of function;Genes;Genetic Transcription;genomic profiling;Genomics;Goals;High Fat Diet;Homeostasis;Hunger;Hypothalamic structure;Impairment;Insulin Resistance;IRF3 gene;Joints;Knock-out;Knockout Mice;Leptin;leptin receptor;Link;liver inflammation;loss of function;Manuscripts;Maps;Mediating;Mentors;Mentorship;Modeling;Molecular;mouse model;Mus;Nature;neural;Neurons;Neurosciences;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;Obese Mice;Obesity;obesity development;obesity treatment;obesogenic;Pathogenicity;Pathway interactions;Peptides;Phase;Physiological;Play;Postdoctoral Fellow;Process;programs;Regulation;Regulatory Pathway;Research;Research Personnel;Resources;response;Ribosomes;Risk Factors;RNA;Role;Satiation;Signal Transduction;single nucleus RNA-sequencing;skills;Structure of nucleus infundibularis hypothalami;success;Techniques;Technology;Testing;therapeutic candidate;Thinness;tool;Training;Transcription Alteration;transcription factor;Transcription Factor 3;transcriptome sequencing;transcriptomics;Translating;Weight Gain;weight maintenance;Work

PROJECT_TITLE: Role of hypothalamic IRF3 transcriptional dysregulation in obesity

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Complementary and Integrative Health;Digestive Diseases;Genetics;Immunotherapy;Nutrition

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in the United States; altered cellular metabolism drives tumorigenesis and progression and promotes resistance to immune checkpoint blockade. Our proposed study will define the metabolic adaptations associated with decreased ketogenesis and will significantly improve the efficacy of immunotherapy for advanced CRC by targeting the dysregulated ketogenesis.

PI_NAMEs: EVERS, BERNARD MARK;WANG, QINGDING  (contact)

PROGRAM_OFFICER_NAME: XI, DAN

PROJECT_TERMS: 3-hydroxy-3-methylglutaryl-coenzyme A;Aerobic;anti-cancer;anti-PD1 therapy;beta catenin;beta-Hydroxybutyrate;Biological Models;c-myc Genes;cancer cell;Cancer Control;Cancer Etiology;cancer therapy;Carbohydrates;CD34 gene;CD8-Positive T-Lymphocytes;Cessation of life;Characteristics;chemokine;Clinical;colon cancer patients;Colorectal Cancer;colorectal cancer progression;colorectal cancer treatment;CXCL6 gene;cytokine;Cytotoxic T-Lymphocytes;Down-Regulation;Enzymes;experimental study;Fatty acid glycerol esters;Fibroblasts;Genetically Engineered Mouse;Glycolysis;Glycolysis Inhibition;Goals;Growth;HDAC1 gene;Histone Deacetylase;Histone Deacetylase Inhibitor;Human;immune checkpoint blockade;immune resistance;Immune response;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;Infiltration;innovation;ketogenesis;ketogenic diet;ketogentic;Ketone Bodies;KRAS oncogenesis;KRAS2 gene;Macrophage;Malignant Neoplasms;Mediating;Metabolic;Metabolism;metabolomics;metastatic colorectal;Metastatic Neoplasm to the Lung;Microsatellite Instability;Microsatellite Repeats;Modeling;Molecular;mouse model;multidisciplinary;Mus;Natural Killer Cells;neoplastic;novel;novel therapeutic intervention;Oncogenes;Oncogenic;patient derived xenograft model;patient prognosis;Patients;PD-1 blockade;Play;Population;PPAR gamma;Production;programs;Proliferating;Publishing;Repression;Resistance;restoration;Role;Signal Transduction;single-cell RNA sequencing;stable isotope;Stromal Cell-Derived Factor 1;Stromal Cells;Stromal Neoplasm;Techniques;Technology;Testing;Therapeutic;therapeutically effective;Treatment Protocols;treatment strategy;tumor;Tumor Immunity;tumor metabolism;tumor microenvironment;Tumor Tissue;tumor-immune system interactions;tumorigenesis;United States

PROJECT_TITLE: Targeting the Immunosuppressive Tumor Microenvironment for Colorectal Cancer Treatment

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Dissemination and Implementation Research;Health Services;Heart Disease;Primary Health Care

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARATIVE Heart failure with preserved ejection fraction (HFpEF) is a type of heart failure with increasing prevalence in older adults in the US. Diagnosis of this type of heart failure is complex and it often remains unrecognized in primary care. In this proposal we aim to develop and pilot test a clinical diagnostic decision support aide, specifically designed for primary care providers to diagnose HFpEF. The ultimate long-term goal is to develop aides for clinicians to use that can improve the diagnosis, and therefore, health outcomes of patients with HFpEF.

PI_NAMEs: KHODNEVA, YULIA  (contact)

PROGRAM_OFFICER_NAME: SIDDIQUI, AYESHA SAEED

PROJECT_TERMS: acceptability and feasibility;Active Learning;Acute;Affect;Alabama;American;American Heart Association;arm;Award;Cardiology;care outcomes;career development;Caring;Clinic;Clinical;Clinical Data;clinical diagnostics;Clinical Medicine;college;Communication;community academic partnership;Community Physician;Community Practice;comorbidity;Complex;Computerized Medical Record;cost;Data;Death Rate;demographics;design;Development;Diagnosis;Diagnostic;diagnostic criteria;diagnostic strategy;Doctor of Philosophy;Early Diagnosis;Echocardiography;Education;efficacy testing;EFRAC;Enrollment;Epidemiology;European;experience;feasibility testing;Focus Groups;Functional disorder;Funding;Future;future implementation;General Practices;Glucose;Goals;Grant;Guidelines;Health;health care delivery;Health Services Research;Heart failure;Heart Rate;Hospitalization;implementation science;improved;improved outcome;inhibitor;innovation;Internist;Intervention;intervention mapping;Interview;K-Series Research Career Programs;Knowledge;Learning Module;Light;Measures;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Modeling;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Newly Diagnosed;novel;older adult;Outcome;Parents;Patient Care;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Physicians;Pilot Projects;pilot test;point of care;poor health outcome;Positioning Attribute;Practical Robust Implementation and Sustainability Model;practice-based research network;Pragmatic clinical trial;preference;preservation;Prevalence;Primary Care;primary care provider;primary outcome;Process;Program Development;Prospective Studies;provider factors;provider-level barriers;Publishing;Pulmonary Hypertension;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;Research Methodology;Research Personnel;Research Priority;research study;Resources;Review Literature;Risk;Risk Factors;Role;Series;skill acquisition;skills;Societies;Sodium;Structure;Surveys;symporter;Testing;therapy development;Time;Training;treatment guidelines;Update;urban area

PROJECT_TITLE: Improving diagnosis of heart failure with preserved ejection fraction in primary care.


ADMINISTERING_IC: AT

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Influenza;Liver Disease;Microbiome;Natural Products;Nutrition;Pneumonia and Influenza

ORG_CITY: ATLANTA

ORG_DEPT: DERMATOLOGY

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE Herbal medicines and dietary supplements are severely under characterized compared to over-the-counter medicines. This creates a critical need for natural product scientists trained in pharmacognosy and drug pharmacokinetics. This project addresses this need through research training focused on metabolic products of antiviral compounds of Elderberry (Sambucus nigra L.) to better understand their anti-influenza activities.

PI_NAMEs: CRANDALL, WILLIAM JOSEPH (contact)

PROGRAM_OFFICER_NAME: KIM, HYE-SOOK

PROJECT_TERMS: absorption;Accounting;Address;Adoxaceae;Anthocyanins;anti-influenza;Anti-viral Agents;anti-viral efficacy;bacteriome;Biological;Biological Availability;Biological Models;Botanical dietary supplements;Botanicals;career;career development;Cell model;Chemical Structure;Chemicals;Complex;Coupled;COVID-19 outbreak;Crude Extracts;Cytochrome P450;defined contribution;Development;dietary supplements;Drug Kinetics;drug metabolism;Elderberry;Environment;Enzymes;Exhibits;experimental study;Flavanol;flu activity;Follow-Up Studies;Foundations;Germ-Free;Gnotobiotic;Goals;gut microbiome;Health;Healthcare;Hepatic;Herbal Medicine;Herbal supplement;High Pressure Liquid Chromatography;Human;Human body;Human Microbiome;improved;In Vitro;in vitro Model;in vivo;Influenza;influenza infection;Infrastructure;Ingestion;Investigation;Knowledge;Liver;Marketing;Mass Spectrum Analysis;Mediating;Medicine;Mentors;Metabolic;Metabolic Biotransformation;metabolic profile;Metabolism;metabolomics;Methods;microbial;microbiome;microbiota;Modeling;mouse model;Mus;Natural Products;novel;Nuclear Magnetic Resonance;oxidation;Pharmaceutical Preparations;Pharmacognosy;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacology;Physiological;Play;polyphenol;Population;Prodrugs;Public Health;Reaction;Research;Research Training;Resolution;response;Role;Safety;Sales;Sambucus nigra;Scientist;Standardization;Sulfate;tandem mass spectrometry;Techniques;Testing;Training;Translations;ultra high pressure;United States;Urine;Viral;Viral Physiology;virology;X-Ray Crystallography

PROJECT_TITLE: Contributions of host and gut microbial mediated metabolism to the antiviral activity of elderberry


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The research aims of the K99/R00 proposal will provide support for a novel pathway of intergenerational trauma through newborn amygdala network connectivity programmed in utero influencing infant emotion regulation problems that may in turn lead to less optimal mother-infant interactions (e.g., disorganized attachment), and result in increased risk for psychopathology across generations. The Award will add to the applicants’ background in perinatal psychology and developmental psychopathology to include needed training in newborn brain imaging, which will enable them to carry out their proposed research and help launch their independent career studying novel pathways of intergenerational trauma through in utero programming – leading to altered early brain-behavior and increased risk for psychopathology – informing critical malleable windows for early intervention. The applicant will obtain training in newborn functional magnetic resonance imaging (fMRI), laboratory observational assessment of infant emotion regulation problems and parenting sensitivity, theory and science of intergenerational trauma, and biostatistics.

PI_NAMEs: BABINEAU, VANESSA  (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: abuse neglect;Address;Adult;Affect;Amygdaloid structure;Anxiety;Anxiety Disorders;archived data;Award;Behavioral;Biological;biological sex;Biometry;Black race;Brain;brain behavior;Brain imaging;career;Child;Child Abuse and Neglect;Child Rearing;Childhood;clinical application;clinically relevant;Conceptions;Data;Data Set;Development;Early Intervention;emotion regulation;Emotional;executive function;experience;Family dynamics;Functional Magnetic Resonance Imaging;Future;Generations;Goals;Health;Health behavior;Hispanic;Image;imaging study;in utero;Indigenous;Infant;Infant Behavior;Infant Health;infant outcome;interdisciplinary approach;intergenerational;Intervention;Knowledge acquisition;Laboratories;Lead;Left;Literature;Magnetic Resonance Imaging;Mediating;Mediation;Mediator;Mental Depression;Mental Health;Mothers;Motor Cortex;multimodality;Network-based;Newborn Infant;next generation;novel;Outcome;Participant;Pathway interactions;Pattern;Perinatal;perinatal mental health;Play;Population;postnatal;Postpartum Depression;Prefrontal Cortex;Pregnancy;prenatal;prenatal influence;programs;psychologic;Psychology;Psychopathology;psychosocial;Reporting;Research;Research Domain Criteria;Rest;Risk;risk mitigation;Role;Sampling;Science;Scientist;Shapes;Smiling;social;social health determinants;socioeconomics;Stress;Structure of superior frontal gyrus;Technical Expertise;Teenagers;Testing;theories;Training;transmission process;Trauma;United States

PROJECT_TITLE: Maternal Childhood Maltreatment-Influenced Prenatal Programming of Early Brain-Behavior and Risk for Future Psychopathology


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Clinical Research;Dementia;Nanotechnology;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: DURHAM

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Alzheimer’s disease (AD) is a devastating neurodegenerative disease with no cure, imposing a major healthcare and economic strain worldwide. Standardization for an easy-to-use and reliable biomarker-based diagnosis of AD is lacking, resulting in invasive, high-cost tests of variable accuracy that may put the patient at risk. Thus, there is a significant need to develop highly accurate, sensitive, and minimally invasive diagnostic methods to promote improved treatment strategies and standardize AD diagnosis. The proposed project aims to create a liquid biopsy platform for AD that is capable of fully automated, rapid, precise exosome isolation and ultrasensitive, accurate exosome analysis from blood/plasma, realizing a point-of-care platform for early-stage AD diagnostics and treatment.

PI_NAMEs: HUANG, TONY JUN  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Acceleration;accurate diagnosis;Acoustics;Address;Affect;Alzheimer disease detection;Alzheimer disease screening;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease diagnostic;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease test;Alzheimer's disease therapeutic;Alzheimer's disease therapy;Alzheimer’s disease biomarker;amplification detection;Behavioral;Benchmarking;Biological Markers;biomaterial compatibility;Biometry;Blood;Blood - brain barrier anatomy;Brain imaging;Brain Pathology;Cerebrospinal Fluid;Clinical;clinical application;clinical diagnosis;Clinical Research;cognitive ability;Communication;Computer software;cost;cost efficient;Detection;Development;Devices;Diagnosis;diagnostic platform;Diagnostic Procedure;Diagnostic tests;diagnostic tool;Disease;Disease Progression;Early Diagnosis;Early treatment;Economic Burden;Electronics;exosome;extracellular vesicles;functional decline;Future;global health;health economics;Healthcare;imaging modality;Impairment;improved;Intuition;invention;Language;Libraries;liquid biopsy;Liquid substance;Longitudinal Studies;Machine Learning;medical schools;Memory impairment;Methods;MicroRNAs;minimally invasive;Molecular;Monitor;nanophotonic;NanoPillar;nanoplasmonic;nanoscale;Neurodegenerative Disorders;novel;Nucleic Acids;Optics;Patient-Focused Outcomes;Patients;Performance;Persons;photonics;Physiological;Plasma;plasmonics;point of care;point-of-care diagnostics;Positron-Emission Tomography;pre-clinical;Proteins;prototype;Research;Research Personnel;response;Risk;Sampling;screening;Source;Specificity;Speech;Speed;Spinal Puncture;Standardization;Symptoms;System;Techniques;Technology;Testing;Therapeutic;Time;tool;trafficking;treatment response;treatment strategy;United States;Universities;Validation;Whole Blood

PROJECT_TITLE: Automated High-purity Exosome isolation-based AD diagnostics system (AHEADx)