ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: TUCSON

ORG_DEPT: ZOOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Although RNA is found in the ejaculate of many organisms, including humans and important insect vectors of human pathogens, little is known about its potential function. This project investigates the function of proteins derived from male RNA that are translated within the reproductive tract of females. The results of these studies will provide novel insights into the role of ejaculate RNA in mediating reproductive outcomes and may inform the design of novel therapies to treat idiopathic infertility and the design of new strategies for controlling insect vectors of human disease.

PI_NAMEs: BONO, JEREMY MATTHEW;MATZKIN, LUCIANO MATIAS (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Area;Automobile Driving;Behavior;Biological Assay;Cells;clinically significant;Complex;Copulation;design;Drosophila genus;Ejaculation;exosome;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;extracellular vesicles;Female;female reproductive tract;Fertility;Funding;Goals;Human;human disease;human pathogen;idiopathic infertility;Immunity;Incidence;Individual;Insect Control;Insect Vectors;Insecta;insight;interest;Investigation;Life;macromolecule;male;Mammals;Mediating;Molecular;novel;novel therapeutics;offspring;Organism;Partner in relationship;Play;protein function;Proteins;Proteomics;Reporting;Reproduction;reproductive;reproductive outcome;Reproductive Physiology;Research;response;RNA;Role;Seminal fluid;sex;Source;sperm cell;System;Tissues;Transcript;Transfer RNA;Translating;Translations;Trees;Variant;Work

PROJECT_TITLE: Investigating a novel role of ejaculate RNA in fertility

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Genetics;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Urologic Diseases;Women's Health Research

ORG_CITY: RICHARDSON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

ORG_STATE: TX

PHR: Project Narrative Klebsiella quasipneumoniae, is a distinct and understudied Klebsiella species associated with human disease including urinary tract infection (UTI), which is among the most common adult bacterial infections affecting more than 150 million people annually. Despite its growing recognition as a serious, often multiple-drug resistant human pathogen, the prevalence of K. quasipneumoniae in human UTI and mechanisms utilized by K. quasipneumoniae to establish infection have not been investigated to date. This proposal aims to fill this critical gap in knowledge by defining the clinical prevalence of K. quasipneumoniae in UTI in women and investigating virulence and colonization mechanisms used by recent clinical isolates of K. quasipneumoniae to establish UTI in a well-established mouse model.

PI_NAMEs: DE NISCO, NICOLE JANELL (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acute;Acute Cystitis;Adult;Adult women;Affect;Age;Animal Model;Antibiotic Resistance;Antimicrobial Resistance;Bacteria;Bacterial Adhesion;bacterial community;Bacterial Infections;Benchmarking;Binding;biobank;Biological Assay;Bladder;C-terminal;C3H/HeN Mouse;Clinical;Confocal Microscopy;Cystitis;defined contribution;DNA Binding Domain;Enterobacteriaceae;Epithelial Cells;Epithelium;Escherichia coli;Exhibits;experience;Genes;Genome;genome sequencing;Genomics;Gentamicins;Goals;Health;Hour;Human;human disease;human pathogen;Hybrids;In Vitro;Infection;Infective cystitis;Invaded;Kidney;Klebsiella;Klebsiella pneumoniae;Knowledge;Lung;Measurement;Measures;Mediating;Menopausal Status;Metabolic;Metadata;Methods;Mining;Mobile Genetic Elements;Modeling;mouse model;Multi-Drug Resistance;Mus;N-terminal;nanopore;Nucleic Acid Regulatory Sequences;Operon;Patients;Periodicity;Persons;Phenotype;phosphoric diester hydrolase;Play;Prevalence;Publishing;Quality of life;Recurrence;Regulation;resistance gene;Role;Sequence Alignment;Sequence Analysis;Site;Structure;Surface;Surgical Wound Infection;System;type 1 fimbriae;Urethra;Urinary tract;Urinary tract infection;Urine;Uropathogen;Uropathogenic E. coli;urovirulent isolates;Virulence;Virulence Factors;whole genome;Woman;Work

PROJECT_TITLE: Urovirulence and fimbrial regulation in Klebsiella quasipneumoniae

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: JOHNSON CITY

ORG_DEPT: SURGERY

ORG_NAME: EAST TENNESSEE STATE UNIVERSITY

ORG_STATE: TN

PHR: Endothelial cell senescence is a hallmark of aging-related cardiovascular disease. Studies in this proposal will explore the novel role of HSPA12B in endothelial cell senescence and define how endothelial cell senescence drives myocardial metabolic reprogramming, hypertrophy, and dysfunction. Proposed studies will advance our understanding of endothelial cell senescence in age related cardiomyopathy and provide new targets and strategies to prevent age related cardiac remodeling and heart failure.

PI_NAMEs: WANG, XIAOHUI  (contact)

PROGRAM_OFFICER_NAME: GAO, HONGWEI

PROJECT_TERMS: Acetyl Coenzyme A;Address;Adult;Age;age related;aging related;Astrocytes;ATF6 gene;Biogenesis;blood glucose regulation;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Cause of Death;Cell Aging;Cell Cycle Arrest;Cell Senescence Induction;Cessation of life;Conditioned Culture Media;Data;Development;Disease;Endothelial Cells;Endothelium;Enzymes;Etoposide;Exhibits;factor A;Fibroblasts;Fibrosis;Functional disorder;Gender;Gene Expression;Genes;Genetic Transcription;Glucose;Glycolysis;hallmarks of aging;Heart failure;Heart Hypertrophy;Homeostasis;human old age (65+);Hypertrophy;Immune;Impairment;Inflammation;Innovative Therapy;Maintenance;Mediating;Metabolic;Metabolic Diseases;Mitochondria;Mitochondrial DNA;mtTF1 transcription factor;Mus;Myocardial;Myocardial dysfunction;neurotrophic factor;novel;oxidation;Patients;Phosphorylation;Play;prevent;Production;protective effect;protein folding;Pyruvate;pyruvate dehydrogenase kinase 4;Regulation;Role;senescence;senescence associated secretory phenotype;Signal Transduction;Tissues;transcription factor;Transcriptional Activation

PROJECT_TITLE: Role of endothelial cell senescence in age-related cardiomyopathy

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Estrogen;Heart Disease;Menopause;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Aging women are at an increased risk for cardiovascular disease, which is the number-one cause of death for women in the US; those who experience vasomotor symptoms (hot flushes and night sweats) have a 55% increased risk of cardiovascular disease compared with women who do not experience vasomotor symptoms. The proposed research aims to determine whether autonomic regulation and vascular control are altered in postmenopausal women with vasomotor symptoms and uses a novel and innovative approach to determine how a hot flush influences blood pressure regulation. Findings from this study will break new ground on mechanisms that link vasomotor symptoms to cardiovascular disease in these women and will further inform future research on preventive and treatment strategies to improve cardiovascular health in aging women.

PI_NAMEs: KELLER-ROSS, MANDA LINEA (contact)

PROGRAM_OFFICER_NAME: DUTTA, CHHANDA

PROJECT_TERMS: Adult;Age;Aging;aging process;associated symptom;Baroreflex;Blood flow;Blood Pressure;blood pressure elevation;blood pressure regulation;Blood Vessels;cardioprotection;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Cause of Death;Cholesterol;Chronic;Clinical Research;Data;design;Development;Doctor of Philosophy;endothelial dysfunction;Endothelium;Estrogens;experience;Exposure to;Female;Forearm;Goals;Heating;Hot flushes;Impairment;improved;Individual;innovation;insight;Laboratories;Lead;Link;male;Measures;medical schools;Menopausal Symptom;Menopause;Methodology;Minnesota;Mission;mortality;Muscle;Nature;Nerve;Night Sweating;novel;novel therapeutics;Observational Study;Pathway interactions;Physical Medicine;Physicians;Physiologic pulse;Physiological;Plethysmography;Positioning Attribute;Postmenopause;Premenopause;Prevention strategy;professor;Regulation;Rehabilitation therapy;Research;response;Risk;Signal Transduction;stressor;System;targeted treatment;Techniques;Temperature;Testing;tonometry;treatment strategy;United States National Institutes of Health;Universities;vasomotor symptoms;Venous;Water;Woman;Women's Health;Women's mortality

PROJECT_TITLE: Vasomotor symptoms of menopause and cardiovascular disease: What is the link?

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ADMINISTERING_IC: HD

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;HIV/AIDS;Infectious Diseases;Microbiome;Nutrition;Pediatric;Pediatric - AIDS;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Despite breastfeeding and maternal anti-retroviral therapy, HIV-exposed uninfected infants have substantially higher risk of growth faltering and morbidity than HIV-unexposed uninfected infants. The proposed project will leverage a unique funded Kenyan birth cohort (NICHD 5R01HD096999) including lactating women living with and without HIV and their infants and expand this cohort to include targeted metabolomics of the maternal plasma and breastmilk to characterize the complex relationship between the mother-breastmilk-infant triad and identify metabolomic profiles associated with the infant gut microbiome and infant growth. Findings from this study will be used to develop targeted metabolomic and microbiome interventions for vulnerable HIV-exposed uninfected infants.

PI_NAMEs: HENDRIXSON, DAVID TAYLOR (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: Achievement;acylcarnitine;Affect;Africa South of the Sahara;Age Months;antiretroviral therapy;Biological;Biometry;Birth;Breast Feeding;career;Child;cohort;Competence;Complex;Data;Development;Elements;Epidemiology;Essential Amino Acids;experience;Funding;Future;Goals;Growth;gut dysbiosis;gut microbiome;high risk;HIV;HIV Infections;HIV-exposed uninfected infant;Human Milk;human milk oligosaccharides;Immune system;improved;Infant;infant adiposity;infant gut microbiome;Infant Health;infant nutrition;infant outcome;insight;Intervention;Knowledge;Lactation;Learning;Life;lipidomics;Lipids;longitudinal analysis;Longitudinal cohort study;Machine Learning;Maternal Health;Mediating;Metabolic;Metabolic dysfunction;metabolome;metabolomics;Methods;microbiome;microbiome composition;microbiome therapeutics;Modeling;Monitor;Morbidity - disease rate;mortality;Mothers;multiple omics;National Institute of Child Health and Human Development;Nitrogen;nutrition;Obesity;Outcome;Participant;Pathway interactions;peer;Perinatal;Persons;Plasma;poor health outcome;Positioning Attribute;prospective;Research;Research Personnel;Risk;Role;Sampling;Serum;skills;translational clinical trial;Tryptophan;Woman;Work

PROJECT_TITLE: The effect of the maternal plasma and breastmilk metabolome on the infant gut microbiome and growth

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PI_NAMEs: ABBASZADEH, SHIVA ;FURENLID, LARS R (contact);KING, MICHAEL A

PROGRAM_OFFICER_NAME: WANG, SHUMIN

PROJECT_TERMS: 3-Dimensional;absorption;Algorithms;Architecture;attenuation;Brain;Brain imaging;Calibration;CdZnTe;Characteristics;Classification;classification algorithm;Code;Compensation;Compton radiation;Computer software;computerized data processing;Data;deep learning;Deposition;design;Detection;detection platform;detector;Development;digital;Discipline of Nuclear Medicine;Electronics;Elements;Event;Gamma Cameras;Gamma Rays;Geometry;Head;Housing;Human;human imaging;Hybrids;Image;image reconstruction;imager;imaging modality;Imaging Phantoms;in vivo imaging;instrument;interest;Isotopes;Joint repair;kinematics;Laboratories;Language;Liquid substance;Maps;Measurement;Measures;Methods;Modeling;models and simulation;molecular imaging;Motion;Noise;novel strategies;Outcome;Patients;Pattern;Performance;phantom model;Phase;Photons;Physics;Positioning Attribute;Positron;Positron-Emission Tomography;Probability;Process;prototype;quantum;quantum sensing;Radioisotopes;radiotracer;reconstruction;Recovery;Research Design;Resolution;Rodent;Rodent Model;Semiconductors;Signal Transduction;simulation;Sorting;Speed;Structure;System;Techniques;Technology;theories;Time;tomography;translation to humans;uptake;vector;Visualization;Work;Xenon

PROJECT_TITLE: Development of a combined Gamma/Positron system for molecular imaging of the human brain at sub-500 micron spatial resolution


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Complementary and Integrative Health;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: The mechanisms by which anesthetics induce unconsciousness, amnesia, and immobilization are poorly understood. We aim to characterize the anesthetic effects of a novel intravenous sedative-hypnotic agent, determine how it prevents forebrain mitochondria from generating an adequate mitochondrial membrane potential, and identify a new pharmacologically relevant anesthetic target. Success will provide insight into mechanisms of anesthesia and will permit us to develop the safest and most effective sedative-hypnotics in future work.

PI_NAMEs: LEVY, RICHARD J (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Adverse effects;Amnesia;analog;Anesthesia procedures;Anesthetics;Aspartate;Behavioral;Benzoquinones;Binding;Biochemical;Biological Assay;Biological Response Modifier Therapy;Body Temperature;Calcium;clinical practice;clinically relevant;Closure by clamp;Conscious;Consumption;Coupled;Critical Illness;Data;Day Surgery;design;Development;Dose;Electroencephalography;Electron Transport;Electrons;falls;Fluorescence;Foundations;Future;General Anesthesia;Genetic;genetic approach;Glutamates;heart function;Hypnosis;hypnotic;Image;Immobilization;In Vitro;in vivo;inhibitor;Injections;Inner mitochondrial membrane;insight;Intravenous;Ion Cotransport;Kinetics;Knockout Mice;Knowledge;Lasers;Link;Measures;Mediating;member;Membrane Potentials;Mitochondria;mitochondrial membrane;Modernization;movement analysis;multi-photon;Multienzyme Complexes;Mus;Natural regeneration;Neurons;neurophysiology;novel;oxidation;para-benzoquinone;Patients;pharmacodynamic model;pharmacokinetics and pharmacodynamics;pharmacologic;Polarography;prevent;Process;Propofol;Prosencephalon;proteoliposomes;Proton Pump;Proton-Motive Force;Protons;Quinones;Ramp;Reflex action;Respiration;response;Role;Sedation procedure;sedative;Siblings;solute;Source;Specificity;Spectrophotometry;success;Synaptosomes;Tail;targeted treatment;Testing;Time;Toxic effect;Transgenic Mice;Ubiquinone;Unconscious State;Veins;Vitamin K 2;Work

PROJECT_TITLE: Discovery and Development of a Benzoquinone Molecule as a Novel Anesthetic

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Data Science;Dissemination and Implementation Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Pediatric Cardiomyopathy;Precision Medicine;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Hypertrophic cardiomyopathy is one of the most common inherited cardiovascular diseases and increases risk for major adverse cardiovascular outcomes; however, only 13% of patients are appropriately diagnosed, indicating a significant diagnostic and therapeutic gap. To address this, the proposed research will use machine learning applied to electronic health record data to develop generalizable models to identify patients with undiagnosed hypertrophic cardiomyopathy and clinically relevant predictors of underdiagnosis. This will inform the dissemination and implementation of best practice approaches to accurately diagnose and appropriately treat patients with hypertrophic cardiomyopathy.

PI_NAMEs: REZA, NOSHEEN  (contact)

PROGRAM_OFFICER_NAME: PRICE, CANDICE

PROJECT_TERMS: Academic Medical Centers;accurate diagnosis;Address;Adverse event;Advisory Committees;Affect;Arrhythmia;Attitude;attributable risk;Bioinformatics;biomedical referral center;black patient;Calibration;cardiac muscle disease;Cardiomyopathies;Cardiovascular Diseases;Cardiovascular system;care delivery;career;career development;Classification;Clinical;Clinical Informatics;clinical phenotype;clinically relevant;Code;cohort;comorbidity;Complex;Consolidated Framework for Implementation Research;cost;Coupled;Data;Data Science;Data Scientist;Data Set;Derivation procedure;Detection;Development;Development Plans;Diagnosis;Diagnostic;diagnostic algorithm;diagnostic criteria;Diagnostic Imaging;diagnostic tool;Discrimination;Disease;Disease Surveillance;Dissemination and Implementation;diverse data;Early Diagnosis;EHR research;Electrocardiogram;Electronic Health Record;Evaluation;Family member;Funding;future implementation;Genetic;genomic data;Goals;hands-on learning;Health system;Heart failure;high dimensionality;Hypertension;Hypertrophic Cardiomyopathy;implementation science;implementation strategy;implementation study;improved;Individual;informatics tool;Inherited;inherited cardiomyopathy;Institution;Interview;K-Series Research Career Programs;Laboratories;Left Ventricular Hypertrophy;Machine Learning;machine learning classification;machine learning model;machine learning prediction;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Modality;model generalizability;Modeling;multimodality;Outcome;Patient Care;patient oriented;patient population;Patients;Pennsylvania;Performance;Persons;Phenotype;Population;Population Heterogeneity;portability;pre-clinical;precision medicine;predictive modeling;prevent;prospective;Publishing;Research;research and development;Research Personnel;Risk;risk mitigation;risk stratification;Site;Source;Stroke;Sudden Death;Symptoms;targeted treatment;Therapeutic;Training;trait;United States;Universities;Validation

PROJECT_TITLE: Improving the Detection of Hypertrophic Cardiomyopathy Using Machine Learning Applied to Electronic Health Record Data

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative Monoclonal gammopathy of undetermined significance (MGUS) is a precancerous condition affecting ~3.5 million Americans. Other than active surveillance, there is no treatment to prevent MGUS from progressing into cancers, the vast majority of which are incurable. The proposed CAP-MGUS Center will be one of the few in the nation to facilitate the development of innovative agents against high-value targets in MGUS patients and thereby establish a foundational infrastructure to fast-track precision medicines for cancer prevention and interception.

PI_NAMEs: LI, YONG  (contact)

PROGRAM_OFFICER_NAME: VLAD, ANDA MIOARA

PROJECT_TERMS: Affect;Age Years;American;Amyloid;Automobile Driving;Blood;Bone Marrow;Bone Marrow Cells;Cancer Center;cancer diagnosis;cancer invasiveness;cancer prevention;cancer risk;Chemicals;Chemoprevention;Chronic Lymphocytic Leukemia;clinical practice;Communication;Consensus;Dedications;Development;Diagnosis;Diagnostic;Disease;DNA Vaccines;early phase clinical trial;efficacy evaluation;follow-up;Funding;Ganciclovir;Goals;Hematological Disease;high risk;IgE;Immunoglobulin A;Immunoglobulin D;Immunoglobulin G;Immunoglobulin M;Immunoglobulins;Immunologics;Immunoprevention;In Vitro;in vivo;Infrastructure;innovation;Intercept;Intervention;Investigation;Life Expectancy;Light;Light-Chain Immunoglobulins;Lymphoid;Malignant Neoplasms;Molecular;Monoclonal gammopathy of uncertain significance;Multiple Myeloma;multiple myeloma M Protein;Mutate;Network Infrastructure;Non-Hodgkin's Lymphoma;novel;Oncogenic;Oncoproteins;Patients;Persons;Plasmacytoma;Population;Population Control;Precancerous Conditions;precision cancer prevention;precision oncology;prevent;Prevention;Preventive;primary amyloidosis of light chain type;Process;programs;progression risk;Protein Secretion;Proteins;Recommendation;Research;research and development;Research Personnel;Research Project Grants;Risk;Risk Factors;Role;senescence;small molecule;Specialized Center;Syndrome;targeted agent;Testing;tumor initiation;tumor progression;ubiquitin-protein ligase;Waldenstrom Macroglobulinemia

PROJECT_TITLE: Cancer Prevention-Interception Against MGUS Progression


NIH_SPENDING_CATS: Cancer;Hematology;Prevention

PROJECT_TERMS: Affect;Age Years;Arkansas;Bioinformatics;cancer prevention;career;Clinical;Collaborations;college;Communication;Communities;community engagement;Data;Dedications;Development;Ensure;Funding;Genetic;genomic data;Genomics;Hematological Disease;Hematology;Hematopoietic Neoplasms;Human Resources;Immune;Immunoglobulin M;Intercept;interest;Knowledge;Laboratories;Leadership;Logistics;Malignant Neoplasms;Medical;Medicine;meetings;member;Mentors;Molecular;Monoclonal gammopathy of uncertain significance;novel strategies;Oncology;operation;outreach;Patients;Persons;Population;Precancerous Conditions;precision cancer prevention;prevent;Prevention;Productivity;Program Evaluation;programs;Progress Reports;Quantitative Evaluations;Reagent;Research;Research Activity;Research Personnel;Research Project Grants;Resource Sharing;Resources;Science;Scientist;Site;Site Visit;Specialized Center;Specimen;success;tool;Training;Universities;web site;Work

PROJECT_TITLE: Administrative Core


PI_NAMEs: ZHAN, FENGHUANG  (contact)

PROJECT_TERMS: Acceleration;Age;Aging;Automobile Driving;Biological Markers;Biology;bone;Bone Marrow;cancer prevention;CDKN2A gene;Cell Aging;cell growth;Cell Proliferation;Cells;Cellular biology;Cellular Metabolic Process;cellular targeting;Cessation of life;Chromosomal translocation;Chromosome 14;cytokine;Cytometry;Data;design;Development;Disease;DNA;Ectopic Expression;Elderly;Excision;extend lifespan;Ganciclovir;Gene Expression;Genetic;Goals;Growth;Growth Factor;Hematopoietic Neoplasms;high risk;Human;human monoclonal antibodies;IGH@ gene cluster;Immune;Immunoglobulin A;Immunoglobulin G;Immunoglobulins;Immunologic Surveillance;immunosenescence;Immunosuppression;Interleukin-6;Iron;iron metabolism;Lesion;Light;Link;luminescence;Lytic;Macrophage;Malignant Neoplasms;Molecular;Molecular Abnormality;Molecular Target;Monoclonal gammopathy of uncertain significance;mouse model;Multiple Myeloma;Mus;neoplastic cell;novel;novel strategies;novel therapeutic intervention;old mice;Patients;Persons;Plasma Cells;Play;Population;premalignant;Prevalence;prevent;Prevention;Proteins;Risk Factors;Role;Sampling;secretory protein;senescence;senescence associated secretory phenotype;senescent cell;Signal Pathway;single-cell RNA sequencing;T-Lymphocyte;Testing;Transgenic Mice;Transgenic Organisms;tumor microenvironment;tumor progression;Work

PROJECT_TITLE: Prevention of MGUS Progression to MM by Modulating the Bone Marrow Microenvironment


PI_NAMEs: YU, XINFANG  (contact)

PROJECT_TERMS: Adaptor Signaling Protein;Affect;Agammaglobulinaemia tyrosine kinase;Amino Acid Substitution;Amyloidosis;Antibodies;Artificial Intelligence;Attenuated;B-Cell Activation;B-Lymphocytes;Binding;Binding Sites;Biochemical Reaction;cancer prevention;causal variant;Cells;Chemicals;Chronic Lymphocytic Leukemia;Collaborations;deep learning;DNA;DNA Vaccines;driver mutation;drug discovery;efficacy validation;Extranodal;Genes;Growth;Human Cell Line;humanized mouse;Immune;Immunity;Immunoglobulin M;Immunologics;In complete remission;Inflammation;Interleukin-1 Receptors;Knock-out;large cell Diffuse non-Hodgkin's lymphoma;Leucine;Light;Link;Lymphoma;Lymphoma cell;Lysine;Malignant Neoplasms;Mediating;Missense Mutation;Modification;Monoclonal gammopathy of uncertain significance;morphogens;Mus;Mutation;Myelogenous;Names;neoplastic cell;neural network;Non-Hodgkin's Lymphoma;Nuclear;Oncogenic;Oncoproteins;p65;Pathogenesis;Pathway interactions;Patients;Phosphotransferases;Physiological;plasmid DNA;Polyubiquitin;Polyubiquitination;Positioning Attribute;Post-Translational Protein Processing;premalignant;prevent;Prevention;Primary Neoplasm;Proline;protein degradation;Proteins;response;Ring Finger Domain;Risk;screening;Signal Pathway;Signal Transduction;small molecule;T cell response;Technology;Testing;Testis;TLR3 gene;TNFRSF5 gene;Toll-like receptors;Toxic effect;Transgenic Organisms;tumorigenesis;ubiquitin-protein ligase;Ubiquitination;Vaccination;vaccine candidate;virtual;Waldenstrom Macroglobulinemia;Work;Xenograft procedure

PROJECT_TITLE: Prevent IgM MGUS Progression by Targeting the Driver Mutation


NIH_SPENDING_CATS: Genetics

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Three-dimensional RNA structures contribute to the most fundamental cellular activities and represent attractive targets for small molecule drugs, especially for diseases associated with “undruggable” proteins. The traditional methods for structure determination of RNA, X-ray crystallography and NMR spectroscopy, require laborious RNA preparation and structure determination experimentation while more facile single-particle cryo- EM cannot be applied to most RNAs because of their small size. We propose to develop a novel methodology for RNA structure determination that includes a conceptually different biochemical approach for streamlined preparation of RNA samples and circumvents the restrictions of conventional cryo-EM structure determination.

PI_NAMEs: SERGANOV, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Binding;Biochemical;Biological Assay;Biological Process;Cell Physiology;Chemicals;Classification;Complex;Computer Models;computerized data processing;Computing Methodologies;cost;Cryoelectron Microscopy;Crystallography;Data Collection;data structure;design;Development;Disease;DNA;DNA-Directed RNA Polymerase;drug discovery;Drug Targeting;effective therapy;Elements;experimental study;Future;Genetic Transcription;Heterogeneity;human disease;hydrophilicity;Immobilization;improved;In Vitro;innovation;insight;interest;Knowledge;Length;Lesion;Location;macromolecular assembly;Methodology;Methods;Modeling;Movement;nanoarchitecture;new technology;NMR Spectroscopy;novel;novel strategies;Oligonucleotides;particle;Pharmaceutical Preparations;Pharmacologic Substance;Positioning Attribute;Preparation;promoter;Proteins;Reaction;Resolution;RNA;RNA chemical synthesis;RNA Folding;RNA purification;RNA Stability;RNA-targeting therapy;Role;Sampling;scaffold;Site;small molecule;Small RNA;Structure;Technology;Thermodynamics;three dimensional structure;tool;Transcript;viral RNA;X-Ray Crystallography

PROJECT_TITLE: A universal approach for determining three-dimensional RNA structures

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health

ORG_CITY: Newark

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE A lack of diversity in the biomedical workforce is recognized to be an enduring problem, even though diversity significantly contributes to the health of our nation through greater research discoveries. This project will investigate whether individualized professional coaching as an intervention increases the success of URG biomedical Ph.D. students, and their transition into sustained, productive careers.

PI_NAMEs: BLITZ, CYNTHIA ;MILLONIG, JAMES H. (contact);RUNNELS, LOREN W

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Academia;Accreditation;Address;Anxiety;anxiety reduction;aspirate;Biomedical Research;Biometry;Black race;Blinded;career;Career Mobility;Data;Data Collection;design;Disparity;Disparity population;Doctor of Philosophy;doctoral student;dosage;Economics;Education;education research;Educational Models;effective intervention;Effectiveness;effectiveness evaluation;Elements;equity, diversity, and inclusion;Ethnography;experience;experimental group;experimental study;Faculty;Fellowship;Frequencies;General Population;Goals;Health;Hispanic Populations;improved;innovation;Institution;instrument;International;Intervention;Interview;Investigation;Knowledge;Link;Long-Term Effects;Measures;medical schools;Medical Students;Mental Depression;Mental Health;Methodology;Methods;New Brunswick;Nursing Students;Occupations;Outcome;Outcomes Research;Output;Population;Problem Solving;Productivity;psychologic;Publications;Randomized;Reproducibility;Reproducibility of Results;Research;Research Personnel;research study;resilience;Self Efficacy;Self Perception;Students;success;Testing;Time;Training;Training and Education;Underrepresented Populations;United States National Institutes of Health;Universities

PROJECT_TITLE: Investigation of Professional Coaching as an Intervention to Support the Success of URG Biomedical Ph.D. Students


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: DALLAS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Narrative Aging impairs antiviral T-cell immunity and increases the severity of infectious diseases caused by viral infection. Using a mouse coronavirus infection model, this study will define the molecular mechanisms underlying the age- associated decline in the antiviral T-cell immunity. The results from this study will provide important implications for future development of strategies to improve antiviral T-cell immunity in the elderly.

PI_NAMEs: WU, TUOQI  (contact)

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: 2019-nCoV;Age;age related;age related changes;age related decline;aged;Aging;Antigens;antiviral immunity;Apoptosis;Binding;Binding Sites;Biological Assay;CD8-Positive T-Lymphocytes;Cell Lineage;Cells;Cellular Metabolic Process;Cessation of life;Chromatin;Chronic;Communicable Diseases;Coronavirus Infections;Data;Defect;Development;Elderly;Epigenetic Process;Equilibrium;exhaust;exhaustion;experimental study;Flow Cytometry;Frequencies;Future;Genes;genetic signature;Genetic Transcription;human old age (65+);IL2 gene;Immune;Immune response;Immunity;immunosenescence;Impairment;improved;In Vitro;Individual;Infection;influenza infection;Metabolic;Metabolic Pathway;metabolic rate;Metabolism;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Murine hepatitis virus;Mus;old mice;Older Population;pathogenic virus;pathological aging;Pathway interactions;Prevalence;programmed cell death protein 1;programs;Role;SARS coronavirus;Severities;Signal Transduction;single-cell RNA sequencing;Stimulus;T cell differentiation;T cell response;T-Lymphocyte;T-Lymphocyte Subsets;transcription factor;transcriptome;transcriptome sequencing;vaccine efficacy;Viral;Viral hepatitis;Virus;Virus Diseases;XCL1 gene

PROJECT_TITLE: Understand the molecular mechanism of age-associated decline in antiviral CD8 T cell immunity

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Prevention;Rare Diseases

PI_NAMEs: SHAUGHNESSY, JOHN DAMIAN (contact)

PROJECT_TERMS: archive data;Archives;Arkansas;arm;base;bench to bedside;bench-to-bedside translation;Benign;Bioinformatics;Biology;Biopsy;bone;bone cell;Bone Marrow;Bone marrow biopsy;cancer prevention;Candidate Disease Gene;Cells;Characteristics;Clinical;clinical investigation;Clinical Research;Clinical Trials;CST6 gene;Data;data archive;data infrastructure;data management;data sharing;Database Management Systems;Databases;Development;Diagnosis;Disease;Enrollment;Ensure;experimental study;Gene Expression Profiling;Genes;genetic analysis;Genomics;Grant;Image;Immune system;informatics infrastructure;innovation;Laboratories;Lesion;Longterm Follow-up;Malignant - descriptor;Malignant Neoplasms;Medical;Methods;Molecular;Monoclonal Gammapathies;Monoclonal gammopathy of uncertain significance;Multiple Myeloma;Natural History;neoplastic cell;Outcome;Pathway interactions;patient population;Patients;PET/CT scan;Phase;Plasma Cell Neoplasm;Plasma Cells;Premalignant Cell;Premalignant Change;prognostic;Publishing;Recording of previous events;repository;Research;Research Project Grants;Resources;Retrieval;Risk;Role;Sampling;Science;Serial Magnetic Resonance Imaging;single-cell RNA sequencing;System;Techniques;Testing;Therapeutic Intervention;Time;Tissue-Specific Gene Expression;Tissues;translational research program;tumor heterogeneity;Universities;Update;user-friendly;virtual;Waldenstrom Macroglobulinemia;Work

PROJECT_TITLE: Bioinformatics Core


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Depression;Health Services;Mental Health;Neurodegenerative;Palliative Care;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Family members and friends are the core of the uncoordinated system of care that tenuously maintains persons living with dementia in their community settings and delays their placement into more costly settings of institutional care, providing more contributed and out of pocket care support than Medicare and Medicaid combined. The CAN-DO program fills a significant gap in caregiver psychoeducation programing by focusing not principally on day-to-day care management but on the many substantial system navigation tasks that caregivers assume. Supported by preliminary efficacy data, CAN-DO will employ state-of-the art asynchronous interactive learning methods to enhance caregivers’ mastery of skills and confidence to navigate healthcare and other (legal, financial, social service, and family) systems that are crucial to the continued community living of persons affected with dementia illnesses.

PI_NAMEs: CLEVENGER, CAROLYN KAY (contact);HEPBURN, KEN W

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Affect;Alzheimer's disease related dementia;Anxiety;Area;arm;attentional control;Behavioral Symptoms;care recipients;care systems;Caregiver Burden;caregiver interventions;caregiver stress;Caregivers;caregiving;Caring;cohort;community living;community setting;Complex;Coping Behavior;cost;COVID-19;COVID-19 pandemic;Data;Decision Making;Dementia;dementia care;Dementia caregivers;depressive symptoms;design;Development;E-learning;Education;Educational Models;Enrollment;Ensure;Exclusion;Exercise;Family;Family Caregiver;Family member;Feedback;Fortune;Friends;Geography;group intervention;hands-on learning;Health;Healthcare;Healthcare Systems;Height;Home;Hour;improved;informal caregiver;Institution;Institutionalization;instructor;instrument;Intervention;Interview;Knowledge;learning strategy;Legal;Life;Managed Care;Measures;Mediation;Medicare/Medicaid;Mental Depression;Methods;Morbidity - disease rate;pandemic disease;Participant;Persons;Pilot Projects;Play;prevent;Program Development;programs;prototype;psychoeducation;Psychological reinforcement;psychological symptom;Quality of life;Race;Randomized;Reporting;Role;Safety;Sampling;Self Efficacy;skills;skills training;social determinants;Social Work;socioeconomics;standard measure;Stress;Structure;Symptom Burden;System;Testing;Time;treatment as usual;Vertebral column;volunteer;Waiting Lists;Well in self

PROJECT_TITLE: Caregiver as Navigator-Developing Skills Online (CAN-DO): Developing Dementia Family Caregiver Mastery for Navigating Complex Health, Social Service, Legal, Financial, and Family Systems


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Immunization;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PUBLIC HEALTH RELEVANCE Glioblastoma (GBM) is the most common primary brain tumor in adults, is essentially incurable, and is associated with significant morbidity. In this project, we will develop a novel class of targeted cytotoxic therapies using DNA aptamers (single-stranded folded DNA molecules) conjugated to potent cellular toxins. The goals of this project are to identify individual aptamer-drug conjugates for treatment of GBM and to provide a roadmap for how these aptamer-drug conjugates could be easily identified for essentially any cancer.

PI_NAMEs: MAHER, LOUIS JAMES;SARKARIA, JANN N. (contact)

PROGRAM_OFFICER_NAME: DHRUV, NEEL TUSHAR

PROJECT_TERMS: 3-Dimensional;Address;Adult;Affinity;Antibodies;Antibody Diversity;Antibody Therapy;Antibody-drug conjugates;aptamer;Binding;Biological;Blood - brain barrier anatomy;Brain;Brain Neoplasms;brain tissue;Cells;Central Nervous System;Characteristics;Chemicals;clinical efficacy;Coupled;Cultured Cells;Cytotoxic Chemotherapy;cytotoxicity;Data;design;Development;DNA;DNA Folding;DNA Library;Dose;Drug Kinetics;effective therapy;Epitopes;Event;Evolution;Excision;experience;FDA approved;Genetic Recombination;Glioblastoma;Goals;Heterogeneity;In Vitro;in vivo;Individual;Infiltration;Injections;innovation;Laboratories;Libraries;Ligands;macromolecule;Malignant Neoplasms;Methods;Modification;Morbidity - disease rate;National Institute of Neurological Disorders and Stroke;neoplastic cell;Neurologic;neurovascular unit;next generation sequencing;Normal Cell;Normal tissue morphology;novel;novel strategies;Operative Surgical Procedures;Organ;patient derived xenograft model;Patients;Pharmaceutical Preparations;Phase;Population;Population Heterogeneity;precision medicine;Preparation;Primary Brain Neoplasms;Process;process optimization;programs;Proteins;Protocols documentation;public health relevance;Radiation Dose Unit;Reproducibility;Research;Resected;Rewards;Risk;RNA;screening;Shapes;single cell sequencing;Single-Stranded DNA;Solid;Specificity;targeted agent;Targeted Toxins;Technology;Therapeutic;Therapeutic antibodies;Time;Tissue Banks;Tissues;Toxin;Toxin Conjugates;Training;Treatment Efficacy;treatment strategy;tumor;tumor DNA;tumor heterogeneity;Vertebrates;Vision;Work

PROJECT_TITLE: In vivo SELEX strategies to identify potent aptamer-drug conjugates for glioblastoma

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Sleep, breathing, hemodynamic oscillations, and cerebrospinal fluid movements – Building toward a novel treatment approach for Alzheimer's disease We will quantify the degree of coupling between cerebral blood volume (CBV) and cerebral spinal fluid (CSF) movement during wake and sleep states and understand the influence of respiration on CBV and CSF flow fluctuations during wake and sleep states.

PI_NAMEs: SCHWICHTENBERG, AMY J;TONG, YUNJIE  (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: abeta accumulation;Adult;Alzheimer's Disease;American;Amyloid beta-Protein;Animals;awake;Behavior;Biological;Blood;Blood Circulation;Brain;Breathing;Cardiac;cerebral blood volume;Cerebrospinal Fluid;Cerebrovascular Circulation;Circulation;Clinical Trials;Coupled;Coupling;cranium;Cues;Diagnosis;fluid flow;Frequencies;Functional Magnetic Resonance Imaging;glymphatic system;Goals;hemodynamics;high reward;Human;improved;Individual;individual variation;Intervention;Knowledge;Link;magnetic resonance imaging/electroencephalography;Measures;Meditation;middle age;Movement;Nerve Degeneration;Neurodegenerative Disorders;Neurons;non rapid eye movement;novel;Outcome;Participant;Pathology;Pathway interactions;Pattern;Physiological;Physiological Processes;Pilot Projects;pressure;Process;Quality of life;Research;Respiration;Sampling;Scanning;Signal Transduction;Sleep;Sleep Deprivation;Sleep Disorders;Sleep Stages;Slow-Wave Sleep;System;tau Proteins;Testing;Tissues;Variant;Visual;Wakefulness;wasting;Work

PROJECT_TITLE: Sleep, breathing, hemodynamic oscillations, and cerebrospinal fluid movements - Building toward a novel treatment approach for Alzheimer's disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: OVERALL NARRATIVE: Pathogens continue to emerge, spread from host-to-host, evolve and cause a wide range of diseases that have major impacts on human and animal health. This is a global problem and the mission of the University of Pittsburgh Regional Biocontainment Laboratory is to study these emerging infectious diseases and to accelerate the development of novel interventions and medical countermeasures to prevent them, in a safe and secure environment. Our vision is to be a globally recognized, highly-collaborative, creative and forward-facing team of infection biologists who are poised to respond to emerging biological threats both at the national and international level.

PI_NAMEs: DUPREX, WILLIAM PAUL (contact)

PROGRAM_OFFICER_NAME: DIAZ SAN SEGUNDO, FAYNA C

PROJECT_TITLE: Pitt RBL


ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

PHR: Project Narrative The overarching mission of the University of Tennessee Health Science Center Regional Biocontainment Laboratory (RBL) is to provide leadership and support in the discovery and development of new drugs, vaccines and diagnostics that would protect the general population from emerging and reemerging infectious diseases and bioterrorism. This proposed application will contribute to this mission by enhancement of resilience of the RBL facilities, BSL-3 practices, and drug discovery capabilities.

PI_NAMEs: JONSSON, COLLEEN B (contact)

PROJECT_TERMS: Abbreviations;Acceleration;Accountability;Animal Model;animal tissue;antimicrobial;Area;Basic Science;biocontainment facility;biodefense;Bioterrorism;Certification;Client;Collaborations;Communication;Communities;Competence;Containment;Core Facility;Dedications;Development;Diagnostic;drug development;drug discovery;Educational workshop;efficacy study;Emerging Communicable Diseases;end of life;Ensure;Equipment;Equipment and supply inventories;experimental study;Facility Controls;Fostering;General Population;Goals;good laboratory practice;Government;Health;Health Sciences;Heart;Histology;Hospitals;Image;imaging modality;improved;Individual;Infectious Agent;infectious disease model;Infrastructure;International;laboratory facility;Leadership;lectures;Maintenance;Mechanics;Medical;Medical center;medical countermeasure;meetings;Mission;Molecular Chaperones;Monitor;novel therapeutics;operation;pandemic preparedness;pandemic response;pathogen;Pediatric Hospitals;Persons;Pharmaceutical Preparations;Pharmacodynamics;prevent;Preventive;Productivity;professional atmosphere;programs;promote resilience;Protocols documentation;Publications;Research;Research Personnel;Research Support;Resource Sharing;Safety;Saint Jude Children's Research Hospital;Secure;Security;Services;Strategic Planning;Strategic vision;Structure;System;Tennessee;Training;Translational Research;Universities;Vaccines;Viral;X-Ray Computed Tomography

PROJECT_TITLE: Enhancement of Resilience of the UTHSC RBL Facility, Biosafety and Countermeasure Discovery


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

PI_NAMEs: FITZPATRICK, ELIZABETH ANN (contact)

PROJECT_TERMS: Air Purifying Respirators;Animals;Basic Science;biocontainment facility;biodefense;Carbon Dioxide;Certification;Client;Containment;Contract Services;Contracts;Core Facility;Decontamination;Development;end of life;Engineering;Equipment;Failure;Goals;Health Sciences;improved;Incubators;Individual;Infectious Agent;Infrastructure;Interruption;laboratory facility;Life Expectancy;life span;Maintenance;Mechanics;Medical;Mission;Monitor;Mus;Occupational Exposure;operation;Outcome;Periodicals;prevent;Procedures;Process;Productivity;programs;promote resilience;Regulation;Research;Research Personnel;Research Support;Services;System;Tennessee;Translational Research;Universities;Validation

PROJECT_TITLE: Facility Management, Maintenance and Operation Core


PROJECT_TERMS: Acceleration;Address;Adherence;Administrator;animal resource;Animals;arm;biocontainment facility;biodefense;Biological;Biology;biosafety level 3 facility;biosecurity;Bioterrorism;Businesses;Certification;cohort;Collaborations;Complex;cost;Creativeness;Decontamination;Development;Discipline;Effectiveness;Emergency Situation;Emerging Communicable Diseases;emerging pathogen;Engineering;Ensure;Environmental Health;Event;Evolution;Goals;high standard;Human Resources;improved;Infection;Information Technology;Infrastructure;International;Intervention;Laboratories;Laboratory Animals;Logistics;Maintenance;medical countermeasure;member;Mission;Modeling;Modernization;Monitor;National Institute of Allergy and Infectious Disease;novel;operation;pandemic disease;pandemic preparedness;pathogen;Pathogenesis;preclinical development;pressure;programs;quality assurance;Regulation;repaired;Research;Research Activity;research facility;response;Rest;Running;Safety;Scientist;Secure;Security;Services;Structure;System;Time;Toxin;transmission process;Universities;Vaccine Research;Veterinarians;Viral;Vision;Work

PROJECT_TITLE: Operations Core


PI_NAMEs: KONG, YING  (contact)

PROJECT_TERMS: Accountability;Animals;Area;Aromatase;Biochemistry;biocontainment facility;biodefense;biosecurity;Certification;Collaborations;college;Communication;Competence;Containment;Dedications;Development;Emerging Communicable Diseases;Engineering;Ensure;Equipment;Equipment and supply inventories;Faculty;Focus Groups;Funding;Goals;Growth;Health Sciences;Human Resources;Immunology;Individual;Institution;instrumentation;Investments;laboratory facility;Laboratory Study;Medicine;member;Microbiology;Mission;operation;pandemic disease;pandemic preparedness;pandemic response;pathogen;Persons;Pharmacy facility;Productivity;professional atmosphere;programs;promote resilience;Protocols documentation;Research;research facility;Research Personnel;Research Support;Safety;Secure;Security;Services;Site Visit;Specialist;Tennessee;Training;United States National Institutes of Health;Universities;Viral;Wages;Work;working group

PROJECT_TITLE: BSL-3 Practices Core


PROJECT_TERMS: Acceleration;Accountability;Administrator;animal resource;Animals;biocontainment facility;biodefense;Biological;Biology;biosafety level 3 facility;biosecurity;Bioterrorism;Certification;cohort;Complex;Creativeness;data integrity;data quality;data quality/integrity;Discipline;Elements;Emergency Situation;Emerging Communicable Diseases;emerging pathogen;Engineering;Ensure;Environmental Health;Equipment and supply inventories;equipment training;Event;Evolution;Goals;hands on instruction;Human Resources;In Vitro;in vivo;Industry;Infection;Infrastructure;International;Intervention;Laboratories;Laboratory Animals;Laboratory Assistant;Lead;medical countermeasure;member;Mentors;Mission;Monitor;National Institute of Allergy and Infectious Disease;novel;operation;Outcome;pandemic disease;pandemic preparedness;pathogen;Pathogenesis;preclinical development;Procedures;programs;quality assurance;Reference Standards;Regulation;Reporting;Reproducibility;Research;research facility;Research Personnel;response;Rest;Running;Safety;Scientist;Secure;Services;Side;Standardization;Supervision;System;Toxin;Training;transmission process;Tube;Universities;Vaccine Research;Veterinarians;Viral;Vision;Work

PROJECT_TITLE: Practices Core


PROJECT_TERMS: Abbreviations;Animal Model;animal tissue;antimicrobial;Award;biocontainment facility;Biomedical Research;Communication;Consumption;Containment;Development;drug development;drug discovery;Drug Exposure;Educational workshop;efficacy study;Equipment;experience;Funding;Goals;good laboratory practice;Histology;Human;Image;imaging modality;Immunohistochemistry;improved;In Vitro;in vivo;Infection;infectious disease model;instrument;instrumentation;laboratory facility;liquid chromatography mass spectrometry;Maintenance;Manuals;Mass Spectrum Analysis;Mission;operation;Paraffin Embedding;Paraffin Tissue;pathogen;Pharmaceutical Preparations;Pharmacodynamics;Phase;pre-clinical assessment;preclinical development;Procedures;Process;promote resilience;prophylactic;Research;RNA Viruses;screening;Services;Site;small molecule;Specialist;Targeted Research;Therapeutic;Time;Tissues;Training;Vendor;Viral;Work;X-Ray Computed Tomography

PROJECT_TITLE: Antiviral & Antimicrobial Countermeasures Discovery and Development Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biomedical Imaging;Emerging Infectious Diseases;Infectious Diseases;Vector-Borne Diseases

PROJECT_TERMS: Acceleration;Administrator;Aerosols;Alpha Virus;Animal Model;Animals;arm;Avian Influenza A Virus;biocontainment facility;biodefense;bioimaging;Biological;Biology;Bioluminescence;biosafety level 3 facility;biosecurity;Bioterrorism;Cells;Cellular biology;Clinical;cohort;Complex;Confocal Microscopy;Coronavirus;Creativeness;Data;digital;Dimensions;Discipline;disease model;Emergency Situation;Emerging Communicable Diseases;emerging pathogen;Engineering;Ensure;Equipment;Event;Evolution;experience;Felis catus;Ferrets;Fluorescence;Hamsters;imaging capabilities;Immune response;Immunoassay;Immunology procedure;In Vitro;in vivo;in vivo imaging;Infection;Infrastructure;International;Intervention;Investments;Laboratories;Laboratory Personnel;Laboratory Technicians;medical countermeasure;Mission;Modeling;Monitor;multimodality;Mus;nonhuman primate;novel;operation;Orthobunyavirus;Orthomyxoviridae;Oryctolagus cuniculus;pandemic disease;pandemic preparedness;pathogen;Pathogenesis;Pathogenicity;PET/CT scan;preclinical development;programs;prophylactic;quality assurance;Rattus;Recombinants;Reporter Genes;Reporting;Research;research facility;Research Infrastructure;Research Personnel;response;Rest;reverse genetics;Rodent;Running;Scientist;Secure;Services;Side;single cell sequencing;single molecule;single photon emission computed tomography;System;Testing;Therapeutic;Therapeutic Intervention;Tissues;Toxin;Training;transmission process;Universities;Vaccine Research;Veterinarians;Viral;Vision;whole body imaging;Work

PROJECT_TITLE: Integrated Services Core


NIH_SPENDING_CATS: Aging;Cardiovascular;Heart Disease;Prevention;Women's Health Research

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Lp(a) is a pro-thrombotic risk factor, but it is not known if aspirin modified Lp(a)-mediated risk in the primary prevention setting in individuals without prior cardiovascular disease. This grant will assess whether aspirin reduces the risk of cardiovascular events mediated by elevated levels of Lp(a). Findings from this grant will provide clinicians with information to decide whether to prescribe aspirin in subjects with elevated Lp(a).

PI_NAMEs: TSIMIKAS, SOTIRIOS  (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Adult;Affect;Antifibrinolytic Agents;apolipoprotein Lp(a+);Apolipoproteins B;Aspirin;Biological Assay;Blood Platelets;Blood Vessels;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Cessation of life;Clinical;clinical development;Clinical Research;Collaborations;Coronary heart disease;Data;Diabetes Mellitus;efficacy outcomes;Elderly;Enrollment;Equipoise;Event;Exclusion;Family history of;follow-up;Genetic;Grant;high risk;human old age (65+);Individual;Inflammation;inhibitor;Intracranial Hemorrhages;Ischemic Stroke;Lipoprotein (a);Low-Density Lipoproteins;Measures;Mediating;men;Meta-Analysis;Modernization;Myocardial Infarction;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Patients;Persons;pharmacologic;Phospholipids;Physicians;Placebos;Plasma;platelet function;Populations at Risk;Prevention therapy;Primary Prevention;prospective;prospective test;Randomized;randomized placebo controlled trial;randomized trial;receptor;Research Personnel;response;Risk;Risk Factors;Risk Reduction;Role;Secondary Prevention;Single Nucleotide Polymorphism;Stroke;Subgroup;Testing;Transient Ischemic Attack;United States;Woman;Women's Health

PROJECT_TITLE: Aspirin, Lp(a) and Primary Prevention of Cardiovascular Events

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


ADMINISTERING_IC: EY

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Humans and other animals use eye, head, and whole-body movements to command where they are looking and what they are paying attention to, and despite the visual consequences of these movements, perception remains stable. The goal of this proposal is to advance our understanding of the visual and premotor mechanisms which facilitate the continuity of visual perception across saccades. This research has implications for the diagnosis, treatment, and rehabilitation of patients with saccadic eye movement disorders and other human neurological syndromes which disrupt eye movements.

PI_NAMEs: HUNT, JOSHUA B (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: active vision;Affect;Animals;Attention;awake;Ballistics;Behavior;Brain;Calcium;cell type;Dedications;density;desensitization;Diagnosis;Disease;Electrophysiology (science);Environment;experience;experimental study;extracellular;Eye;Eye Movements;gaze;Generations;Genetic;Goals;Head;Human;Image;improved;in vivo;Injury;Interneurons;Investigation;Midbrain structure;Modification;Molecular;Motion;Motor;Motor Activity;Movement;Mus;neural;neural circuit;neural correlate;Neurologic;Neurons;Ocular Motility Disorders;oculomotor;optogenetics;Output;Patients;Perception;Photic Stimulation;Population;programs;Public Health;Rehabilitation therapy;Research;response;Retina;Retinal Ganglion Cells;Role;Saccades;Shapes;Signal Transduction;Site;Source;Stimulus;Structure;superior colliculus Corpora quadrigemina;Syndrome;System;Testing;Time;tool;two photon microscopy;two-photon;Vision;Visual;Visual Motion;visual motor;Visual Perception;visual processing;visual stimulus;Visual System

PROJECT_TITLE: Dissecting the visuomotor circuit for saccadic suppression in the superior colliculus


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Hematology;Nutrition

PHR: PROJECT NARRATIVE The proposed project aims to biochemically characterize the role of the ubiquitous mitochondrial protein unfoldase CLPX in erythroid heme synthesis. Completion of this project will fundamentally enhance our understanding of the mechanisms underlying diseases caused by defects in heme synthesis, such as anemias, porphyrias and mitochondriopathies, and how tissue-specific factors regulate and modify ubiquitous metabolic pathways. Because a disproportionate number of anemic patients are women and children, the success of this project will have particular impact on the management of their health.

PI_NAMEs: YIEN, YVETTE Y (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Affect;Allosteric Regulation;Anemia;ATP phosphohydrolase;ATP-Dependent Proteases;Bacterial Proteins;Biochemical;Cell Differentiation process;Cell Line;Cells;Cellular biology;Child;cofactor;Complex;Coupled;Couples;Coupling;Defect;design;Disease;Enzymatic Biochemistry;Enzymes;Erythroid;Erythroid Cells;erythroid differentiation;Erythropoiesis;experimental study;Family;Functional disorder;Genes;Goals;Health;Hematological Disease;Heme;heme biosynthesis;Heme Iron;Hemoglobin;Homeostasis;Housekeeping;Imaging Techniques;indexing;innovation;insight;Iron;iron metabolism;Iron Metabolism Disorders;Iron Overload;iron supplementation;Iron-Regulatory Proteins;Knowledge;Label;live cell imaging;member;Metabolic;Metabolic Pathway;Metabolism;metabolome;Mitochondria;Mitochondrial Matrix;Mitochondrial Proteins;Modeling;multicatalytic endopeptidase complex;Multienzyme Complexes;Mutation;novel;Pathway interactions;Patients;Peptide Hydrolases;Phenotype;Play;polypeptide;Porphyrias;Porphyrins;Process;Production;Protein Biochemistry;Proteins;proteostasis;Protoporphyrinogen oxidase;Quality Control;Regulation;Role;Severities;Shapes;Structure;success;Techniques;Testing;therapy design;Tissues;translational potential;unfoldase;uptake;Vertebrates;women patients;Yeasts

PROJECT_TITLE: Regulation of erythroid iron metabolism by the CLPX unfoldase

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Data Science;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research

PI_NAMEs: MASURKAR, ARJUN VIJAY;RAZAVIAN, NARGES  (contact)

PROGRAM_OFFICER_NAME: PLUDE, DANA JEFFREY

PROJECT_TERMS: Address;Algorithm Design;Algorithms;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease related dementia;American;Black Populations;Calibration;Classification;Clinic;Clinical;clinical biomarkers;Clinical Data;Clinical Trials;Cognitive;cognitive testing;cohort;Cohort Studies;comorbidity;Complex;complex data;Data;Data Set;Data Sources;Dementia;Detection;Diagnosis;Disease;Early Diagnosis;Electronic Health Record;Ensure;ethnic minority;Ethnic Population;Family;fluorodeoxyglucose positron emission tomography;Health;high risk;Hispanic Populations;human old age (65+);Image;imaging biomarker;Impaired cognition;Learning;learning strategy;Longitudinal cohort;Machine Learning;Magnetic Resonance Imaging;Measures;Medical;Methodology;Methods;Modeling;Monitor;multimodal data;multimodality;neuroimaging;novel;patient subsets;Patients;Performance;Population;Population Heterogeneity;Positron-Emission Tomography;Primary Care;primary care setting;racial minority;racial population;Research;Sampling;Scheme;self supervised learning;supervised learning;Target Populations;Techniques;tool;Training;training data;Underrepresented Populations;Woman;Work

PROJECT_TITLE: SCH: Dementia Early Detection for Under-represented Populations via Fair Multimodal Self-Supervised Learning


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: COLUMBIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative/ Public Health Relevance Emerging and re-emerging infectious diseases present unique challenges in the research mission of the NIH/NIAID because pathogen evolution cannot be predicted, and development of medical countermeasures that protect public health is reliant upon well characterized animal models that recapitulate the natural human infection. As these studies demand specialized personnel and building infrastructure, the NIH/NIAID Regional Biocontainment Laboratories were constructed to better address these challenges and prepare for unexpected outbreaks by unknown microbial threats. The proposed program will provide safety, security, and operational support to researchers at the University of Missouri Regional Biocontainment Laboratory in order to address priority pathogens and develop new approaches to prevent and treat infections, thereby improving our preparation for responding to an outbreak of emerging infectious disease.

PI_NAMEs: GRIFFITHS, ANTHONY  (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;Address;Adoption;Animal Housing;Animal Model;animal model development;Appointment;Arboviruses;Area;Award;biocontainment facility;biodefense;combat;Communicable Diseases;Communities;Core Facility;COVID-19;COVID-19 pandemic;Decontamination;Dedications;Development;Disease Outbreaks;Disinfectants;Emerging Communicable Diseases;Equipment;Evaluation;Event;Evolution;experience;Faculty;Funding;future outbreak;Goals;Grant;Growth;Human;Human Resources;Image;Immunology;improved;Infection;Infectious Diseases Research;Influenza;Infrastructure;Institution;instrumentation;Investments;Knowledge;Laboratories;laboratory experiment;Leadership;Maintenance;medical countermeasure;member;microbial;Microbiology;Midwestern United States;Mission;Missouri;Modernization;Names;National Institute of Allergy and Infectious Disease;National Security;new outbreak;new technology;next generation;novel;novel strategies;operation;Output;pandemic disease;pandemic potential;pandemic preparedness;pathogen;Phase;Preparation;prevent;Prevention approach;priority pathogen;Productivity;programs;Public Health;public health relevance;recruit;Regulation;Research;research and development;Research Personnel;Research Support;Resource Development;Resources;response;Role;Safety;Scientist;Secure;Security;Senior Scientist;Services;synergism;System;Technology;Training;transmission process;United States National Institutes of Health;Universities;vaccine platform;vector-borne;Virus;Work;Workforce Development

PROJECT_TITLE: Resources and Workforce Development for Research on NIH/NIAID High Priority Pathogens at the University of Missouri Regional Biocontainment Laboratory


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Prevention

PI_NAMEs: RICHARDSON, MARK D (contact)

PROJECT_TERMS: Advanced Development;Affect;Agreement;Animal Housing;Animals;Area;Arthropods;Award;base;biocontainment facility;biodefense;biosafety level 3 facility;biosecurity;Carbon Dioxide;Chills;Communicable Diseases;Communication;Communities;Containment;Contractor;Decontamination;Dedications;design;Disease;Diverse Workforce;Educational process of instructing;Emergency Situation;Emerging Communicable Diseases;Ensure;Environment;Equipment;Event;falls;Floor;Funding;Goals;high efficiency particulate air filter;Human Resources;improved;Individual;Infectious Diseases Research;Infrastructure;Investments;Laboratories;Leadership;Maintenance;medical countermeasure;meetings;Missouri;Modeling;Names;National Institute of Allergy and Infectious Disease;Natural Gas;novel;operation;pandemic disease;pandemic preparedness;pandemic response;pathogen;pathogenic bacteria;pathogenic virus;Periodicals;Power Sources;Preventive;Preventive service;priority pathogen;Procedures;programs;Property;recruit;repaired;Research;research and development;research facility;Research Priority;Research Support;Resource Development;Resource Sharing;Resources;response;Risk;Safety;Schedule;Science;Secure;Security;Services;Side;Site;skills;Steam;synergism;System;Testing;Training;United States National Institutes of Health;Universities;vector-borne;Veterinary Medicine;Viral;Water;Water Purification;water treatment;Work;Workforce Development;Zoonoses


PI_NAMEs: ADAMOVICZ, JEFFREY JOSEPH (contact)

PROJECT_TERMS: 2019-nCoV;Address;Adopted;Adoption;Aerosols;Area;Attention;authority;base;Basic Science;biocontainment facility;biosafety level 3 facility;Certification;Communicable Diseases;Communities;Competence;Complement;Containment;Continuing Education;Core Facility;COVID-19;Decontamination;Diagnostic;Emergency response;Emergency Situation;Emerging Communicable Diseases;emerging pathogen;Environment;Equipment;Equipment and supply inventories;Exercise;Faculty;Faculty Recruitment;Failure;Family suidae;Goals;Grant;Human Resources;improved;Individual;Infectious disease threat;Infectious Diseases Research;Influenza;Infrastructure;innovation;insight;institutional biosafety committee;instrumentation;interest;International;Investigation;Investments;Laboratories;Location;Maintenance;medical schools;meetings;Methodology;Mission;Missouri;Modernization;Mutant Strains Mice;National Institute of Allergy and Infectious Disease;new technology;operation;Operations Research;pandemic preparedness;pandemic response;pathogen;Play;Positioning Attribute;Precision Health;Prevention strategy;Principal Investigator;priority pathogen;Procedures;Productivity;programs;Public Health;Public Health Schools;Rattus;Readiness;recruit;Reporting;Research;research and development;research facility;Research Personnel;Research Support;Resource Development;Resources;Risk Assessment;Role;Safety;Science;Security;Services;skills;Standardization;Students;Teaching Hospitals;Testing;Training;Training Programs;Translational Research;United States National Institutes of Health;Universities;Vaccines;Variant;Vector-transmitted infectious disease;Work;Workforce Development


PI_NAMEs: OLSON, RACHEL M (contact)

PROJECT_TERMS: 2019-nCoV;Advanced Development;Aerosols;Animal Model;Animals;Area;biocontainment facility;biodefense;Biological Assay;biosafety level 3 facility;Blood Chemical Analysis;Cavia;Cells;Chemicals;Collaborations;Communicable Diseases;Communication;Communities;Containment;Controlled Environment;Core Facility;COVID-19 pandemic;Custom;cytokine;Data;Dedications;Development;Diagnostic;Emerging Communicable Diseases;emerging pathogen;Ensure;Equipment;Evaluation;Event;experience;experimental study;Family suidae;Ferrets;Flow Cytometry;Funding;Goals;Goat;Growth;Hamsters;human disease;human model;Human Resources;Image;Immune response;Immunity;Immunology;in vitro Assay;Infection;Infectious Diseases Research;Inhalation Exposure;instrumentation;Investments;Maintenance;Manufacturer;medical countermeasure;Methodology;Methods;Microbiology;Microscopy;Missouri;Modeling;Monitor;Mus;Mutant Strains Mice;National Institute of Allergy and Infectious Disease;new outbreak;next generation;novel;novel vaccines;Oryctolagus cuniculus;pathogen;pathogen exposure;pathogenic bacteria;pathogenic virus;Persons;pre-clinical;preclinical development;priority pathogen;Procedures;Productivity;programs;Public Health;Rattus;real-time images;Recovery;recruit;Reproducibility;Research;research and development;Research Personnel;Research Support;Resource Development;Resources;response;Route;Safety;Sampling;Scientist;Secure;Services;Sheep;Specialist;Speed;Structure;System;Technical Expertise;Technology;Time;Training;Transgenic Animals;Translating;United States National Institutes of Health;Universities;vector transmission;Viral;Work;Workforce Development

PROJECT_TITLE: Biocontainment Research Support Service(s) Core


PHR: Overall - PROJECT NARRATIVE This proposal will enhance the capabilities of the Rutgers Regional Biocontainment Laboratory to respond to the next public health emergency or pandemic by supporting efficient operations and maintenance of its high-level biosafety laboratory facilities, training and maintaining critical faculty and staff, developing and disseminating state-of-the art safety and disaster response procedures, and developing scientific models of disease.

PI_NAMEs: ALLAND, DAVID  (contact)

PROJECT_TERMS: 2019-nCoV;Address;Aftercare;Animal Husbandry;Animal Model;Animals;Bacillus anthracis;biocontainment facility;Biological Products;biosecurity;biothreat;Budgets;Candida auris;Categories;Cells;Certification;Chikungunya virus;Collaborations;Computers and Advanced Instrumentation;Containment;cost;COVID-19;Cryptococcus;Development;Diagnostic;Diagnostics Research;Disasters;disease model;Emergency response;Emerging Communicable Diseases;end of life;Ensure;Environment;Equipment;Equipment and supply inventories;Faculty;Francisella tularensis;Funding;Goals;Grant;Health;HIV;Impairment;improved;Infectious disease threat;influenzavirus;Institution;Joints;Laboratories;laboratory facility;Laboratory Research;Life Cycle Stages;Lung;Maintenance;Microbiology;Mission;Modeling;Monkeypox;Mycobacterium tuberculosis;operation;pandemic disease;pandemic preparedness;pathogen;Pathogenesis;Pathogenicity;Performance;Pharmacotherapy;Post-Acute Sequelae of SARS-CoV-2 Infection;Procedures;public health emergency;recruit;Research;Research Activity;Research Contracts;Research Personnel;Research Project Grants;Research Support;Research Training;Resources;response;Safety;Scientist;Services;Shipping;System;Therapeutic;Tissues;Training;Tuberculosis;tuberculosis drugs;tuberculosis treatment;United States;United States National Institutes of Health;Universities;Viral;viral transmission;virology;Virulent;Waste Management;Work;Workforce Development;Yersinia pestis

PROJECT_TITLE: Resources,  Workforce Development, and Animal Models for the Rutgers RBL


PI_NAMEs: LAZZARINO, DEBORAH ANN (contact)

PROJECT_TERMS: Address;Aging;Animal Experimentation;Animal Husbandry;Animal Model;Animals;Award;Basic Science;biosafety level 3 facility;biosecurity;biothreat;Capital;Collaborations;Communities;Containment;Core Facility;cost;Cost Savings;Dedications;diagnostic development;Emergency response;emerging pathogen;Ensure;Equipment;Faculty;Floor;Funding;Goals;Grant;Human Resources;improved;Infrastructure;Laboratories;Life Cycle Stages;Maintenance;Microbiology;Mission;Monitor;operation;Performance;Positioning Attribute;Privatization;Process;Productivity;programs;Public Health;public health emergency;Recording of previous events;repaired;Research;Research Personnel;Research Project Grants;Research Support;Resources;response;Safety;Security;Services;Specialist;Structure;System;Technology;Therapeutic;Training;translational research program;Universities;Vaccines;virology;Workforce Development

PROJECT_TITLE: Facility Management, Maintenance and Operations (FMMO) Core


ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: Project Narrative: The BSL3 facilities within the Rocky Mountain Regional Biocontainment Laboratory (RMRBL) at Colorado State University have been responsive to the national RBL mission since 2008, including research and training directed in response to the COVID and MPox pandemics, as well as research and training in other diseases, like Tuberculosis. The RMRBL BSL3 suites are in high demand, and require dedicated management, facilities maintenance, operational support, education and engagement in biosafety and biosecurity practices, and upkeep of relevant scientific technologies to support the studies being performed within this specialized facility. In this application, we address the needs of the RMRBL BSL3 laboratories with 3 Cores to ensure that these facilities are always resourced to face and combat pathogenic pandemic threats; Core 1 is dedicated to improved management, maintenance, and operations, while Core 2 is dedicated to biosafety and biosecurity practices, and finally Core 3 exploits our collective research talents to develop a biocontainment research resource core for pathogen characterization.

PI_NAMEs: DOBOS, KAREN MARIE (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;Address;Adult;aged;American;Animal Husbandry;base;Biocompatible Materials;biocontainment facility;biodefense;biosafety level 3 facility;biosecurity;Bioterrorism;Cells;Chronic;Climate;Collaborations;Colorado;combat;Communicable Diseases;Communication;Competence;COVID-19;Dedications;design;Development;Diagnostic;Disease;Domestic Animals;Education;Educational process of instructing;Educational workshop;Emergency Situation;Emerging Communicable Diseases;Ensure;Environment;Equipment;Event;Evolution;Face;Fellowship;Foundations;Funding;Goals;Grant;Health system;improved;In Vitro;in vivo;industry partner;Infection;Infectious Agent;Infectious disease threat;Information Technology;Infrastructure;innovation;instrument;Investments;Laboratories;laboratory facility;Lead;Learning;Maintenance;mass spectrometric imaging;Mission;Modeling;Modernization;molecular mass;Monkeypox;Monoclonal Antibodies;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;operation;Operations Research;outreach;pandemic disease;pandemic potential;pathogen;Pathogenicity;pathogens of pandemic potential;Performance;Persons;Procedures;professional atmosphere;programs;Public Health;Qualifying;Reagent;recruit;Research;research facility;Research Personnel;Research Support;Resource Development;Resources;response;Rodent;Safety;Scholars Program;Secure;Security;Services;spillover event;Structure;success;symposium;System;Talents;Technology;Therapeutic;Toxin;Training;Training and Education;Training Programs;Translating;Tuberculosis;Universities;usability;vaccine development;Vaccines;Vision;visiting scholar;Work;Workforce Development;Zoonoses

PROJECT_TITLE: Research Resources and Workforce Development for the Rocky Mountain Regional Biocontainment Laboratory at Colorado State University


PI_NAMEs: BHARAJ, PREETI  (contact)

PROJECT_TERMS: Address;animal care;Animal Care and Use Committees;Animal Model;Animals;biocontainment facility;biosecurity;biothreat;Certification;Development;Disasters;Elements;Emergency response;Emergency Situation;Ensure;Environment;Environmental Health;Exercise;first responder;Foundations;Funding;Growth;Health;Human Resources;IACUC;Industry;Information Technology;innovation;Institution;institutional biosafety committee;Institutional Review Boards;Internet;Joints;Laboratories;laboratory experience;Maintenance;Monitor;novel;Occupational Health;operation;pandemic disease;Play;Procedures;Productivity;programs;Protocols documentation;Public Health;Reaction Time;Readiness;Records;Regulatory Affairs;Research;research and development;Resources;response;Risk Assessment;Role;Safety;Science;Secure;Standardization;Structure;System;Time;Training;Training and Education;Training Programs;Training Support;United States Department of Agriculture;Universities;Work;Workforce Development

PROJECT_TITLE: BSL-3 Practices core (Practice core)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

PI_NAMEs: GOODRICH, RAYMOND PAUL (contact)

PROJECT_TERMS: 2019-nCoV;Academia;Address;Administrative Supplement;Advocate;aged;Aging;Animal Husbandry;Basic Science;biocontainment facility;biodefense;Biological;Biological Sciences;biosafety level 3 facility;biosecurity;Burkholderia pseudomallei;Calibration;Capital;Career Choice;Categories;Certification;Client;Collaborations;college;Colorado;Communicable Diseases;Communication;Conflict (Psychology);cost;Cyclic GMP;Data;Dedications;design;Discipline;Disease;Eastern Equine Encephalitis Virus;Economic Burden;Education;Emerging Communicable Diseases;emerging pathogen;Ensure;Entrepreneurship;Environment;Equipment;Evaluation;faculty research;Fees;Foundations;Francisella tularensis;Funding;Genus Mycobacterium;Goals;Good Manufacturing Process;Government Agencies;Grant;Hazardous Chemicals;Hazardous Substances;health economics;Human Resources;improved;Industry;Infectious disease threat;Infectious Diseases Research;Information Systems;Information Technology;Infrastructure;Institution;instrument;Investments;Laboratories;laboratory facility;Leadership;Leprosy;Maintenance;manufacture;Melioidosis;Middle East Respiratory Syndrome Coronavirus;Mission;Modernization;Monkeypox;National Institute of Allergy and Infectious Disease;non-tuberculosis mycobacteria;operation;Operations Research;pandemic disease;pandemic potential;parent project;pathogen;pathogenic bacteria;Pharmacologic Substance;Plague;Process;professional atmosphere;programs;Public Health;repaired;Research;Research Personnel;Research Support;Resolution;Resource Allocation;Resource Development;Resources;response;Risk;Science;Services;Site;socioeconomics;Structure;System;Training;Translational Research;Tuberculosis;Tularemia;Universities;Update;usability;Venezuelan Equine Encephalomyelitis;Vertebral column;Veterinary Medicine;viral pandemic;Vision;visiting scholar;Work;Workforce Development


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Rare Diseases;Tuberculosis

PI_NAMEs: SALGAME, PADMINI  (contact)

PROJECT_TERMS: 2019-nCoV;Address;Affect;Animal Model;Antitubercular Agents;biosafety level 3 facility;biothreat;Birds;Chemotherapy-Oncologic Procedure;Clinical;Containment;COVID-19;Disease;Disease Outbreaks;drug candidate;efficacy testing;Emerging Communicable Diseases;Equipment;Exhibits;experience;Experimental Models;Ferrets;Genes;Goals;Grant;Hamsters;Human;Human Resources;Impairment;improved;in vitro activity;Individual;Infection;Influenza A Virus, H5N1 Subtype;influenzavirus;instrumentation;Intervention Studies;Lung;lung health;Measures;Modeling;mouse model;Mutation;Mycobacterium tuberculosis;new pandemic;novel therapeutics;pandemic disease;pandemic virus;pathogen;Pathogenesis;Pathogenicity;Performance;permissiveness;Persons;Pharmaceutical Preparations;Post-Acute Sequelae of SARS-CoV-2 Infection;pre-clinical;prevent;Probability;programs;Public Health;Regimen;Relapse;Research;Research Personnel;Research Support;Resources;respiratory health;respiratory pathogen;Respiratory System;respiratory virus;response;SARS-CoV-2 transmission;Service animal;Services;Stress;Symptoms;Testing;Therapeutic;Toxic effect;transmission process;treatment duration;Treatment Protocols;Tuberculosis;tuberculosis drugs;Variant;viral transmission;Workforce Development

PROJECT_TITLE: Animal models and related services (AMRS) core


ORG_CITY: LOUISVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: NARRATIVE (OVERALL): The University of Louisville Regional Biocontainment Laboratory (RBL) is a regional resource that facilitates translational research to develop diagnostics, therapeutics and vaccines to mitigate biodefense and emerging infectious disease threats. We propose to establish three cores that will work in unison to achieve the RBL mission to prepare and respond to public health emergencies like pandemics. The cores will be responsible for facility management and operations; for training laboratory workers in safe BSL-3 work practices; and for operating a full-service research support function for scientists who need to use the RBL.

PI_NAMEs: PALMER, KENNETH E (contact)

PROJECT_TERMS: Attention;biocontainment facility;biodefense;Biological Warfare;Biomedical Research;Biotechnology;biothreat;China;Clinical Trials;cohort;Communities;Containment;COVID-19;COVID-19 pandemic;COVID-19 patient;Creativeness;Crowns;Dedications;Diagnostic;Disease Outbreaks;Economics;emergency preparedness;Emerging Communicable Diseases;Ensure;experience;Federal Government;Funding Opportunities;Future;Goals;Health care facility;Health Services Research;Hospitals;Hour;Human Resources;improved;Industry;Infection;Infectious disease threat;Institution;International;Investigational New Drug Application;Kentucky;Laboratories;laboratory experience;Leadership;Learning;Maintenance;Managed Care;medical countermeasure;Medicine;Mentors;metropolitan;Mission;Modeling;National Center for Advancing Translational Sciences;National Institute of Diabetes and Digestive and Kidney Diseases;Nose;novel;novel coronavirus;operation;pandemic disease;pandemic preparedness;pandemic response;pathogen;Patients;Philosophy;Play;previous pandemic;prognostic;prophylactic;Public Health;public health emergency;recruit;Research;Research Personnel;Research Support;Resources;response;Rest;Reverse Transcriptase Polymerase Chain Reaction;Risk;Role;Scientist;Serology test;service organization;Services;skills;System;Talents;Techniques;Testing;Therapeutic;Training;Translational Research;United States National Institutes of Health;Universities;University resources;Vaccines;wastewater surveillance;Work;Workforce Development

PROJECT_TITLE: UofL RBL Operations, Workforce Development and Pandemic Preparedness Research


PI_NAMEs: MORITZ, REBECCA  (contact)


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE (OVERALL) The goal of the BSL3 management and practice of infectious disease research at HTRL is to provide infrastructures and trained personnel to enable rapid responses and research on Risk Group 3 infectious disease threats, including new and re-emerging agents, Select Agent pathogens, or biological toxins, and to share this knowledge with the scientific community and public in a timely manner. HTRL, Howard Taylor Ricketts Laboratory, is one of twelve NIAID-designated Regional Biocontainment Laboratories (RBL). HTRL will operate within the RBL network with the goals of providing harmonized Standard Operating Protocols for cohesive best practices in BSL3/ABSL3 laboratories across our country.

PI_NAMEs: LANGAN, GEORGE PARSONS;MISSIAKAS, DOMINIQUE M. (contact);OSEI-OWUSU, PATRICK

PROJECT_TERMS: 2019-nCoV;Accidents;Air;Animal Model;Antibiotic Therapy;Antibiotics;Articulation;Awareness;Bacteria;Bacterial Infections;biocontainment facility;biodefense;Biological;Biological Assay;Biomedical Research;biosafety level 3 facility;biosecurity;Bioterrorism;Birds;Certification;Chicago;chikungunya;Classification;Clostridium difficile;Collaborations;combat;Communicable Diseases;Communities;companion animal;Containment;Coronavirus;cost;Country;COVID-19;COVID-19 pandemic;Decontamination;Dedications;Dengue;Development;Disease;Doctor of Philosophy;drug resistant pathogen;Ebola virus;Economics;Emergency Situation;Emerging Communicable Diseases;Engineering;Environment;Environmental Health;Epidemic;Equilibrium;Evaluation;Event;Financial Support;Fostering;Frequencies;Funding Opportunities;Genome;Goals;hazard;Health;Human;human disease;Human Resources;Immune response;Immunity;improved;In Vitro;in vivo;Infection;Infectious Agent;Infectious disease threat;Infectious Diseases Research;Influenza;insight;Institution;Investigation;Knowledge;Laboratories;Laboratory Personnel;Leadership;Livestock;Maintenance;Mammals;Measures;Medical;medical countermeasure;meetings;methicillin resistant Staphylococcus aureus;Microbe;microbial;Microbiology;Middle East Respiratory Syndrome Coronavirus;Modeling;Molecular;Morbidity - disease rate;Mutation;National Institute of Allergy and Infectious Disease;operation;Operations Research;Panic;pathogen;pathogenic microbe;Pathogenicity;Persons;Pharmaceutical Preparations;Population;prevent;Preventive;preventive intervention;Procedures;professor;Protective Devices;Protocols documentation;Public Health;public health emergency;Regulation;repaired;Research;Research Activity;Research Support;Resources;response;Risk;RNA Viruses;Role;Safety;SARS coronavirus;Scientist;Secure;Services;Societies;Structure;System;Technology;Testing;Therapeutic Intervention;Toxin;Training;Training Activity;Training and Education;Training and Infrastructure;transmission process;Universities;Vaccines;Variant;Viral;viral outbreak;virtual;Virulence;Virus;web portal;ZIKA;Zoonoses


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Vaccine Related

PROJECT_TERMS: Acute;Animal Model;Animals;Biocompatible Materials;biocontainment facility;biodefense;Biological;Biological Assay;Bioreactors;biosafety level 3 facility;cell bank;Cells;Centers of Research Excellence;cGMP production;Characteristics;Chemicals;Clinical Research;Clinical Trials;Collection;Colorado;Cryoultramicrotomy;Cyclic GMP;Databases;design;Development;Diagnostic;Dissection;Domestic Animals;Emerging Communicable Diseases;emerging pathogen;Equipment and supply inventories;expectation;forging;Fresh Tissue;Growth;health economics;Health system;Histology;Human;Immunity;improved;In Vitro;in vivo evaluation;Infection;Infrastructure;innovation;Investments;Laboratory Animals;laser capture microdissection;manufacturing scale-up;mass spectrometric imaging;Mass Spectrum Analysis;metabolomics;Microbial Physiology;Modeling;molecular mass;multidisciplinary;new technology;Outcome;pathogen;Pathogenesis;pathogenic bacteria;pathogenic virus;pathogens of pandemic potential;Pathology;pre-clinical;preclinical study;Preparation;preservation;Process;Production;programs;Proteomics;Qualifying;Reagent;Recording of previous events;Reproducibility;Research;Research Personnel;Research Support;Resource Development;Resources;response;Sampling;scale up;screening;Series;Services;socioeconomics;spillover event;Study models;synergism;System;Technology;Testing;tool;transcriptomics;transmission process;Universities;vaccine trial;Vaccines;vaccinology;Viral;Workforce Development

PROJECT_TITLE: Biocontainment Research Support Services Core


PI_NAMEs: STEFFEN, MARLENE CLARKE (contact)

PROJECT_TITLE: UofL RBL BSL3 Facility Management, Maintenance and Operations Core


PI_NAMEs: LANGAN, GEORGE PARSONS (contact)

PROJECT_TERMS: 2019-nCoV;animal care;Animal Experimentation;animal resource;Anthrax disease;Area;Bacillus;biocontainment facility;Biomedical Research;biosafety level 3 facility;biosecurity;Brucella;Certification;Chicago;Collaborations;Containment;County;COVID-19;Coxiella;Decontamination;Docking;emerging pathogen;Ensure;Environmental Health;Equipment;ESKAPE pathogens;Future;Goals;Guidelines;Humidity;Illinois;improved;Infectious Diseases Research;Influenza;Institution;Laboratories;life span;Maintenance;methicillin resistant Staphylococcus aureus;Microbiology;Mycobacterium tuberculosis;novel therapeutics;novel vaccines;operation;Operations Research;Organism;pathogenic virus;Pathogenicity;Plague;pressure;Preventive;programs;public health emergency;Readiness;Regulation;repaired;Research;research facility;Research Support;Rickettsia;Safety;Secure;Structure;success;System;Temperature;Testing;United States National Institutes of Health;Universities;Yersinia

PROJECT_TITLE: Facility Management, Maintenance and Operations Core


PI_NAMEs: SEVERSON, WILLIAM E (contact)

PROJECT_TERMS: Accountability;animal facility;Aromatase;biocontainment facility;biodefense;Biological;biosafety level 3 facility;biosecurity;Computer software;Dedications;Development;Emerging Communicable Diseases;Ensure;Environment;Equipment;Equipment and supply inventories;Evaluation;Excision;Exposure to;Goals;Hazardous Substances;Human Resources;Individual;Laboratories;Maintenance;meetings;Mentors;microorganism;Mission;National Institute of Allergy and Infectious Disease;operation;pandemic preparedness;pandemic response;Policies;Principal Investigator;Procedures;Process;professional atmosphere;programs;Protective Devices;Reporting;Research;Research Personnel;Resource Sharing;Resources;Secure;Security;Services;Shipping;Specialist;Toxin;Training;Training and Education;Training Programs;Universities;Update;Waste Management;wasting;Workforce Development

PROJECT_TITLE: UofL RBL BSL3 Practices and Workforce Development Core


ED_INST_TYPE: SCHOOLS OF EDUCATION

ORG_CITY: FAIRFAX

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: GEORGE MASON UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE: OVERALL COMPONENT George Mason University’s Regional Biocontainment Lab serves as a center for scientific collaboration to 1) generate advanced knowledge of pathogen biology and host interaction mechanisms, and 2) evaluate diagnostics, therapeutics and vaccines. This proposal addresses existing gaps and opportunities with solutions to enhance a) safety practices, b) facilities and operations management, and c) research capabilities to more effectively face sudden disease outbreaks and support a more robust pipeline of innovations for response to future pandemics, while continuing to comply with NIAID, CDC, and UDSA/APHIS regulations.

PI_NAMEs: ALEM, FARHANG  (contact)

PROJECT_TERMS: Acceleration;Acute;Address;Alpha Virus;Animal Experimentation;animal imaging;Applied Research;Basic Science;biocontainment facility;Biology;Biomedical Research;biosafety level 3 facility;Bioterrorism;Capital;Certification;Collaborations;Containment;Coronavirus;COVID-19 pandemic;Data;Diagnostic;Disease Outbreaks;drug discovery;Economic Burden;efficacy evaluation;Emerging Communicable Diseases;Engineering;Ensure;Environment;Face;Filovirus;Funding;future pandemic;good laboratory practice;Health;Immune response;improved;in vivo;Individual;Infectious Agent;Infectious Diseases Research;innovation;Knowledge;Laboratories;laboratory facility;Laboratory Research;lead optimization;Leadership;Learning;Maintenance;Mentorship;microphysiology system;Modeling;National Institute of Allergy and Infectious Disease;operation;organ on a chip;Organoids;pandemic preparedness;pathogen;Pathogenesis;Positioning Attribute;pre-clinical;preclinical study;product development;programs;promote resilience;Regulation;Research;research and development;Research Infrastructure;Research Personnel;Resources;response;Safety;safety assessment;safety practice;Secure;Services;success;System;Testing;Therapeutic;Tissues;Toxic effect;Training;training opportunity;Training Programs;transmission process;Universities;Update;Vaccines;Virus Diseases

PROJECT_TITLE: Positioning Mason's Regional Biocontainment Laboratory for Effective Pandemic Preparedness


PI_NAMEs: KANABROCKI, JOSEPH A. (contact)

PROJECT_TERMS: Address;Animals;Area;Attention;Awareness;Biocompatible Materials;biocontainment facility;biodefense;Biological;Biological Products;Biomedical Research;biosecurity;Categories;Chicago;Communication Tools;Communities;Competence;Containment of Biohazards;Coordination and Collaboration;Dangerousness;Decontamination;design;Development;Discipline;Disease;Education;Educational Curriculum;Elements;Emergency response;Emerging Communicable Diseases;Engineering;Ensure;Environment;Equipment;Equipment and supply inventories;experience;Family;Goals;hazard;Human;Human Resources;Individual;Infectious disease threat;Infectious Diseases Research;Infrastructure;investigator training;Laboratories;Laboratory Research;Maintenance;meetings;member;Mentors;microorganism;Mission;National Institute of Allergy and Infectious Disease;operation;pathogen;Pathogenicity;personal protective equipment;Procedures;Program Description;programs;Property;Recommendation;Research;Research Personnel;Resources;Risk;Risk Assessment;Safety;Scientist;Secure;Services;skills;synergism;System;Toxin;Training;Training and Education;Training Programs;United States;Universities;Update;Work

PROJECT_TITLE: BSL-3 Practices Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biomedical Imaging;Emerging Infectious Diseases;Infectious Diseases;Prevention

PROJECT_TERMS: Aging;Alcoholic Liver Diseases;Ally;Alpha Virus;Animal Model;Arthritogenic;Attention;Autopsy;biocontainment facility;Blood Chemical Analysis;Businesses;Cardiometabolic Disease;Centers of Research Excellence;chikungunya;Chronic;Chronic Disease;Clinical;Collaborations;Communicable Diseases;Communities;cost;COVID-19;Data;Data Analyses;Development;Disease;Disease Outcome;Elderly;Emerging Communicable Diseases;Ensure;Environmental Exposure;Environmental Impact;Environmental Medicine;environmental toxicology;Funding;future pandemic;global environment;good laboratory practice;Health;Hematology;Immunology;In Vitro;in vivo;in vivo imaging;in vivo Model;Industrialization;Infection;infectious disease model;instrument;instrumentation;Investigation;Investigational Drugs;Investments;Japanese encephalitis virus;Laboratories;Measurement;medical countermeasure;Metabolic;Metabolic Diseases;Mission;Modeling;mouse model;National Institute of Allergy and Infectious Disease;operation;Outcome;Outcome Study;pandemic potential;pandemic preparedness;pandemic response;pathogen;Pathogenesis;Pathology;Persons;Pharmacodynamics;Physiological;Positron;Positron-Emission Tomography;Powassan virus;programs;pulmonary function;Recovery;Reporting;Reproducibility;Research;Research Design;Research Personnel;Risk;SARS-CoV-2 infection;Scanning;Semliki forest virus;Service delivery model;Services;System;Testing;Toxic Environmental Substances;Toxicant exposure;Translational Research;United States National Institutes of Health;Universities;Viral Pathogenesis;Virus;Virus Diseases;Vulnerable Populations;West Nile virus;Whole Body Plethysmography;Workforce Development;X-Ray Computed Tomography

PROJECT_TITLE: UofL RBL Pandemic Preparedness and Response Integrated Research Core


PI_NAMEs: MISSIAKAS, DOMINIQUE M. (contact)

PROJECT_TERMS: Animal Model;Antibiotic Resistance;Articulation;Bacillus anthracis;Biochemical;biocontainment facility;biodefense;Biological Assay;Biological Products;biosecurity;Cells;Charge;Chicago;Collaborations;Communities;Consultations;Containment;Data;design;Development;Diagnostic;Drug Screening;Emergency response;Emerging Communicable Diseases;Ensure;Environment;Equipment;Event;experience;Genetic;Goals;Growth;Guidelines;Health;high risk;high throughput screening;Immune response;Immunization;In Vitro;in vivo;Infection;Infectious Diseases Research;Infrastructure;Institution;Instruction;instrument;Knowledge;Laboratories;Lead;Learning;Measures;Microbe;microbial;Mission;Mycobacterium tuberculosis;Names;new pandemic;pathogen;Phenotype;Process;Protocols documentation;recruit;Reporting;Research;Research Personnel;Research Support;Research Training;Resistance profile;response;Rickettsia;RNA Viruses;Secure;Services;Sister;skills;small molecule inhibitor;Specimen;Standardization;Supervision;Technology;Testing;Therapeutic;Training;Universities;vaccine development;web page;web portal;Yersinia pestis


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention

ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative During cardiac ischemia, succinate accumulation and adenine nucleotide depletion result in myocardial damage during reperfusion. Little is known about the mechanisms behind these metabolic changes that play major roles in ischemia-reperfusion injury. The goal of this project is to uncover the primary pathways of succinate accumulation and adenine nucleotide depletion in ischemic myocardium using experimental strategies in conjunction with computational models of myocardial metabolism.

PI_NAMEs: COLLINS, NICOLE  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: acronyms;Acute;Adenine Nucleotides;alpha ketoglutarate;Anoxia;ATP Synthesis Pathway;Automobile Driving;Blood flow;Carbon;Cardiac Myocytes;Cell Physiology;Cell Respiration;Citric Acid Cycle;Computer Models;Consumption;Data;Degradation Pathway;Energy Metabolism;Environment;Enzyme Inhibition;Enzyme Inhibitor Drugs;Enzymes;Experimental Designs;experimental study;Exposure to;Fumarates;Generations;Goals;Health;Heart;Heart Mitochondria;Hypoxia;Impairment;improved;Infarction;Inosine Monophosphate;Ischemia;Kinetics;Knock-out;Lead;Malate-Aspartate Shuttle Pathway;Malates;Measurement;Metabolic;Metabolism;metabolomics;Mitochondria;Modeling;Muscle;Myocardial;Myocardial Contraction;myocardial damage;Myocardial Infarction;Myocardial Ischemia;Myocardium;Organ Transplantation;Oxaloacetates;Oxidants;Oxidative Stress;Oxygen;Pathologic;Pathway interactions;Play;predictive modeling;prevent;Prevention;Process;Production;Purine Nucleotides;Purines;Rat Transgene;Rattus;Reaction;Reactive Oxygen Species;Reperfusion Injury;Reperfusion Therapy;Role;Succinate Dehydrogenase;Succinates;Suspensions;System;targeted treatment;Testing;Therapeutic;Time;Tissues;Transportation;United States;Vascular blood supply;Work

PROJECT_TITLE: Pathways of Succinate Accumulation and Adenine Nucleotide Depletion in Cardiac Ischemia


PROJECT_TERMS: 12 year old;Address;Area;biocontainment facility;Biomedical Research;biosafety level 3 facility;Bioterrorism;Capital;Certification;college;Computer software;Containment;Core Facility;Disease Outbreaks;Educational workshop;Emerging Communicable Diseases;end of life;Engineering;Ensure;Environment;Equipment;Equipment Failure;Exercise;Future;Goals;Human Resources;implementation strategy;Improve Access;improved;Infectious Diseases Research;innovation;instrumentation;Interruption;Knowledge;Laboratories;Laboratory Research;Laboratory Study;Leadership;Maintenance;Monitor;National Institute of Allergy and Infectious Disease;operation;pandemic preparedness;pathogen;Positioning Attribute;Preparation;Process;Productivity;programs;Regulation;Research;Research Personnel;Resources;Retirement;Risk;Safety;Schedule;Secure;Security;skills;Structure;success;System;Training;training opportunity;Training Programs;Universities;Work

PROJECT_TITLE: Facilities Management, Maintenance and Operation Core