ADMINISTERING_IC: CE

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE Poverty and income inequality have wide-ranging and disproportionate effects on children and families, including environmental, social-emotional, and behavioral health sequela that elevate risk for community violence. At the same time, limited evidence suggests that strategies addressing structural and social determinants of health by enhancing economic opportunity and helping families avoid financial stress can prevent violence and promote well-being and intersectional racial equity. This project evaluates whether and how two of the largest anti-poverty public policies in the United States—the Earned Income Tax Credit (EITC) and Additional Child Tax Credit (ACTC)—affect the determinants, consequences, and prevention of community violence and racial/ethnic inequities in community violence among low-income families.

PI_NAMEs: BRUNS, ANGELA ;BUGGS, SHANI ;KRAVITZ-WIRTZ, NICOLE DOLORES (contact);ZHANG, XIAOYA

PROJECT_TITLE: RFA-CE-24-030, Preventing Community Violence and Advancing Racial and Health Equity:  The Role of Anti-Poverty Policy

STUDY_SECTION_NAME: Special Emphasis Panel[ZCE1 TQD (30)]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome;Lung;Pulmonary Fibrosis;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative: Fibrotic lung disease is responsible for significant morbidity and mortality, with very few treatment options other than lung transplantation. Abnormal alveolar epithelial differentiation pathways have been implicated in many of these diseases, suggesting that impaired alveolar regeneration may be an important driver of fibrogenesis. We propose to better characterize metaplastic differentiation pathways of the resident epithelial stem cell of the lung alveolus, the alveolar type II (AT2) cell, by using a combination of novel lineage tracing approaches and advanced techniques for epigenetic profiling, with the goal of identifying putative targets for therapeutic intervention.

PI_NAMEs: IANTORNO, STEFANO AZELIO (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Adult;airway epithelium;Alveolar;Alveolar Cell Type I;alveolar epithelium;alveolar type II cell;Alveolus;ATAC-seq;Automobile Driving;Bar Codes;Basal Cell;Behavior;Cell Differentiation process;Cell surface;Cells;ChIP-seq;Cyst;Data;directed differentiation;Disease;Distal;Embryo;Epigenetic Process;epigenetic profiling;epigenetic variation;Epithelial Cells;epithelial stem cell;Epithelium;Extracellular Matrix;Fibroblasts;fibrogenesis;Fibrosis;fibrotic lung disease;Functional disorder;Gases;Gene Expression;Gene Expression Profiling;gene regulatory network;Genetic Transcription;genome-wide;Goals;Histologic;Homeostasis;Human;Immunofluorescence Immunologic;Impairment;In Situ;In Vitro;in vivo;Individual;Injury;lentivirally transduced;Libraries;Lung;Lung Transplantation;Mediating;Metaplasia;Mitochondria;Modeling;Morbidity - disease rate;mortality;Natural regeneration;novel;Organoids;Outcome;Pathway interactions;Phenotype;Physiological;Physiology;Preparation;Process;profibrotic cytokine;programs;Proliferating;prospective;Protocols documentation;Pulmonary alveolar structure;Pulmonary Fibrosis;Regenerative pathway;repaired;Research;Resolution;response;response to injury;Sampling;Signal Pathway;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Slice;Somatic Mutation;Source;Stains;stem cell migration;stem cells;Stress;Structure;Structure of parenchyma of lung;System;targeted treatment;Techniques;Temperature;Testing;Therapeutic Intervention;Time;Tissues;transdifferentiation;Transforming Growth Factor beta;Trees;Type II Epithelial Receptor Cell;Visualization

PROJECT_TITLE: Epigenetic signatures driving metaplastic repair mechanisms in human alveolar type II cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (08)]


ADMINISTERING_IC: AR

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Estrogen;Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Hair growth is driven by the tightly regulated proliferative behaviors of hair follicle stem cells, which behave differently based on biological sex. The proposed research will investigate the molecular mechanisms that drive sexually dimorphic hair follicle stem cell behavior. This work will reveal how genetic and physiological sex differences are integrated into stem cell biology, opening novel avenues for targeted treatment of skin conditions.

PI_NAMEs: REBECCA FREEMAN, REBECCA FREEMAN REBECCA FREEMAN (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Acceleration;Adolescent;Adult;adult stem cell;Affect;Androgen Receptor;androgen sensitive;Androgens;autosome;Behavior;Biological Assay;biological sex;cell behavior;cell type;Characteristics;Complex;Data;Dermal;Development;differential expression;Disease;Excision;Exhibits;Female;Fibroblasts;Foundations;gene function;gene product;Genes;Genetic;genetic manipulation;Gonadal Hormones;Gonadal Steroid Hormones;Gonadal structure;Growth;Hair;Hair follicle structure;hair regeneration;Hormonal;in vivo;Injections;Knock-out;Libido;Life;male;Masks;Mediating;Modeling;Molecular;Monitor;mouse model;Mus;Natural regeneration;Nature;novel;Operative Surgical Procedures;Orchiectomy;Phenotype;Physiological;Play;Population;Positioning Attribute;prevent;Production;programs;Proliferating;Puberty;Regulation;Reporting;Research;Rest;RNA;sex;Sex Bias;Sex Chromosomes;Sex Differences;sexual dimorphism;Signal Transduction;Site;Skin;Stanolone;stem cell biology;stem cell niche;stem cells;System;targeted treatment;Testing;therapy development;Tissues;tongue papilla;tool;trait;Viral;Viral Vector;Wild Type Mouse;Work;XX male;XY females

PROJECT_TITLE: Defining Sexual Dimorphism in the Skin

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10B-Q (20)]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative: Tick-borne diseases are arthropod-borne illnesses of public and veterinary health relevance. In the next phase of this project (R01 competing renewal), we will examine how tick feeding impacts skin homeostasis during microbial transmission and continue to provide exciting discoveries in the field of arthropod vector biology. Specifically, we will: (i) investigate the influence of tick EVs on the interaction between dendritic epidermal T cells and keratinocytes; and (ii) assess the effect of tick EVs on keratinocyte proliferation, migration, and differentiation during microbial transmission.

PI_NAMEs: PEDRA, JOAO  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Abate;acquired immunity;Affect;Ally;Analgesics;Anaplasma phagocytophilum;Animals;Anti-Inflammatory Agents;Anticoagulants;Applications Grants;arboviral disease;Arboviruses;Arthropod Vectors;arthropod-borne;Arthropods;Binding;Biological;Biological Assay;Biology;Black-legged Tick;Blood;Blood coagulation;Cattle;Cavia;Cell Communication;Cell Differentiation process;cell motility;Cell Physiology;Cell Separation;Cells;Color;Communication;Communities;Cutaneous;Data Set;Dermacentor;Dermis;Environment;Epidermis;epithelial wound;Epithelium;experimental study;extracellular vesicles;fascinate;feeding;Fermentation;Flow Cytometry;Francisella tularensis;Funding;Generations;Genetic;Growth Factor;Health;Hemostatic Agents;Hemostatic function;Homeostasis;Human;Imaging Techniques;Immunobiology;Inflammation;Influentials;Injury;insight;interspecies communication;Intervention;intravital imaging;intravital microscopy;Ixodes;keratinocyte;Knowledge;Mammals;Mediating;microbial;microbial disease;migration;Molecular;mouse genetics;Mus;neglect;Nociception;novel;Outcome;pathogen;Pharmaceutical Preparations;Phase;prevent;Proliferating;Property;Protein Secretion;Public Health;Publishing;Reagent;receptor expression;Research Personnel;Resistance;Rickettsia Infections;Role;Salivary;Salivary Proteins;Scientist;single-cell RNA sequencing;Skin;Specialized Epithelial Cell;Stratum Basale;Surface;System;T-Cell Receptor;T-Lymphocyte;Technology;Therapeutic;tick bite;tick feeding;tick saliva;Tick-Borne Diseases;Ticks;tissue repair;tissue resident memory T cell;Tissues;tool;transmission process;Work;wound healing;γδ T cells

PROJECT_TITLE: Tick Saliva and Pathogen Transmission

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-C (02)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Clostridioides difficile is a major public health concern that can cause intestinal diseases including diarrhea and pseudomembranous colitis. C. difficile develops two colony morphologies that exhibit differences in multiple virulence-associated phenotypes. The objective of the proposed study is to identify and characterize genes necessary for colony dimorphism, which may reveal new targets for development of therapeutics for C. difficile infections.

PI_NAMEs: TAMAYO, RITA  (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Affect;Animal Model;Antibiotic Therapy;antibiotic-associated diarrhea;Applied Genetics;Bacteria;Behavioral;Biological Assay;Biomass;Candidate Disease Gene;Cell division;Cells;Cellular Morphology;Cessation of life;Clostridium difficile;combat;Communities;Conserved Sequence;Data;design;Development;Diarrhea;dimorphism;Disease;Exhibits;Future;Gene Expression;gene function;gene product;Genes;Genetic;Genetic Screening;Germination;Growth;Heterogeneity;Hypothetical Protein;In Vitro;Infection;Intestinal Diseases;Link;Microbial Biofilms;Molecular;Molecular Biology;Morbidity - disease rate;Morphology;Motility;mouse model;Mus;Mutagenesis;mutant;Mutation;new therapeutic target;Nosocomial Infections;Pathogenicity;Phase;Phenotype;Physiological;Physiology;Pilot Projects;prevent;Process;Production;promoter;Protein Sequence Analysis;protein structure prediction;Proteins;Pseudomembranous Colitis;Public Health;Recurrence;Research;Role;screening;Signal Transduction;Single Nucleotide Polymorphism;Surface;Swimming;Terminator Codon;Testing;therapeutic development;Toxin;trait;Transcriptional Regulation;Treatment Cost;Variant;Virulence;Work

PROJECT_TITLE: Determinants of Clostridioides difficile colony dimorphism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-M (02)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Cancer;Chronic Pain;Neurodegenerative;Neurosciences;Orphan Drug;Ovarian Cancer;Pain Research;Peripheral Neuropathy;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: IRVINE

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE - No Changes have been made Ovarian cancer affects only women for which cisplatin is a commonly used chemotherapeutic drug but it causes neurotoxicity leading to painful neuropathy, cognitive decline, called `chemobrain' and alterations in gait with increased propensity to fall/fractures, which may continue even after the discontinuation of treatment. We hypothesize that the activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase plays a critical role in cisplatin-induced damage to the nervous system and that inhibition of these pathways will attenuate cisplatin-induced neurotoxic side effects in female mice with ovarian cancer. We expect that the results of our study will lead to the development of novel therapeutics to reduce the debilitating sequelae of cisplatin in women with ovarian and other cancers.

PI_NAMEs: BOTA, DANIELA ANNENELIE (contact);GUPTA, KALPNA

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Adverse effects;Affect;Aftercare;Alzheimer's Disease;anticancer activity;Antineoplastic Agents;Attention;Attenuated;attenuation;Axon;axon injury;Behavioral;Bioenergetics;blood-brain barrier crossing;Brain;Breast;Breast Cancer Model;C57BL/6 Mouse;Cancer Model;Cancer Patient;cancer therapy;Cell Line;chemobrain;chemotherapeutic agent;chemotherapy;Chemotherapy-induced peripheral neuropathy;Cisplatin;Clinical;Clinical Trials;Cognitive;Cognitive deficits;cognitive testing;Data;Dendritic Spines;density;Development;Diagnosis;disability;Disease Progression;DNA Damage;Dose;druggable target;Electrophysiology (science);Epithelial ovarian cancer;Excitatory Synapse;executive function;experience;falls;FDA approved;Female;Fracture;Gait;health disparity;Hippocampus;Impaired cognition;Impairment;improved;In Vitro;in vivo;Individual;Induced Neurons;Induction of Apoptosis;Inflammation;information processing;inhibitor;Injury;Intervention;Kidney;kinase inhibitor;Length;male;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;MAPK8 gene;Memory;men;Mitochondria;Mitochondrial DNA;Mitogen-Activated Protein Kinase Kinases;Mitogen-Activated Protein Kinases;Mitogens;Molecular;Morphology;Motor;multidisciplinary;Mus;N-terminal;Nerve;Nerve Fibers;nerve stem cell;Nervous System;neural;Neurologic;neuron apoptosis;Neurons;Neuropathy;neurotoxic;neurotoxicity;neurotransmission;novel;novel strategies;novel therapeutics;Nuclear;Numbness;ototoxicity;Ovarian;Oxidative Stress;Oxygen;p38 Mitogen Activated Protein Kinase;Pain;painful neuropathy;Painful Paresthesias;Pathway interactions;patient mobility;Patients;Performance;Peripheral;Peripheral Blood Stem Cell;peripheral nerve damage;Peripheral Nervous System;Peripheral Nervous System Diseases;Pharmaceutical Preparations;pharmacologic;Phosphotransferases;Platinum Compounds;Play;prevent;Preventive treatment;Process;processing speed;Proto-Oncogene Proteins c-jun;Quality of life;Rattus;Reporting;Rodent Model;Role;Sensory;side effect;Signal Pathway;Signal Transduction;Skin;Small Interfering RNA;small molecule inhibitor;SP600125;Spinal Ganglia;Symptoms;taxane;Testing;Therapeutic;Time;Toxic effect;Transgenic Organisms;translational potential;United States;Vinca Alkaloids;Woman

PROJECT_TITLE: Supplement to Promote Diversity: Targeting p38/JNK MAPK to ameliorate cisplatin-induced adverse sequelae on the nervous system


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Prevention;Primary Health Care;Rheumatoid Arthritis;Rural Health;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE In rheumatoid arthritis (RA), delaying initiation of treatment for ≥12 weeks is associated with irreversible joint damage due to greater difficulty in achieving remission, but navigating the hurdles of the US healthcare system in this short timeframe can be challenging for rural residents due to the closure of rural hospitals nationwide extending the distance to healthcare facilities and the time to travel and obtain care. The growing rheumatology workforce shortage further aggravates these issues, as <10% of rheumatologists practice in rural or micropolitan areas yet 30% of the US population lives in these areas. Our goal is to reduce healthcare disparities to improve outcomes in patients with RA by (1) identifying rural healthcare disparities in the diagnosis and treatment of early RA, (2) developing and validating an AI algorithm to enable early identification of RA, and (3) assessing long- term outcomes in patients with RA living in rural vs. urban areas compared to those without RA.

PI_NAMEs: CROWSON, CYNTHIA S (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: access disparities;Address;Age;Algorithms;American;Anti-citrullinated peptide antibody;Anti-Rheumatic Agents;Area;Arizona;artificial intelligence algorithm;Caring;Catchment Area;Characteristics;Classification;clinical decision support;clinical practice;Code;cohort;college;comorbidity;Consumption;Continuity of Patient Care;County;Data;Data Set;Databases;Development;Diagnosis;Diagnostic;Disease remission;Disparity in diagnosis;disparity reduction;Early identification;Early treatment;Electronic Health Record;Emergency department visit;Ensure;Epidemiology;Ethnic Origin;European;experience;Florida;functional disability;Goals;Grant;health care delivery;health care disparity;Health care facility;health care service utilization;Health Services Accessibility;Healthcare Systems;Hospitalization;human old age (65+);improved;improved outcome;Intervention;joint injury;Joints;Knowledge;Manuals;Medical;medical specialties;Minnesota;mortality;Obesity;opioid use;Outcome;Outcomes Research;patient subsets;Patients;Persons;Pharmacotherapy;Population;population based;Positioning Attribute;Pragmatic clinical trial;Primary Care;primary care setting;Provider;Qualifying;Race;radiological imaging;Reporting;Research;Rheumatoid Arthritis;Rheumatoid Factor;rheumatologist;Rheumatology;Rural;rural area;Rural Community;rural dwellers;rural health disparities;rural healthcare;Rural Hospitals;Rural Population;rurality;Sensitivity and Specificity;sex;Site;Smoking;Specialist;support tools;Symptoms;Testing;Time;Training;Travel;Triage;unnecessary treatment;urban area;Wisconsin;Woman;Work

PROJECT_TITLE: Population-Based Outcomes Research for Rheumatoid Arthritis: Rural Health Disparities

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


NIH_SPENDING_CATS: Immunotherapy;Infectious Diseases;Lung

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Project Narrative Global mortality among immunocompromised and HIV+ populations by Cryptococcus neoformans (Cn) remains high but development of novel immunomodulatory therapeutics is hampered by 1) poor understanding of the immune responses against Cn and 2) a lack of mouse models that recapitulate human Cn disease. The proposed research addresses this through development of a new Cn-infection mouse model that produces human-like lung granulomas and defining the immune response in these protective granulomas. We also mimic disease in advanced HIV patients to understand how immune deficiency causes granuloma breakdown leading to disease.

PI_NAMEs: BETANCOURT, JOVANY JORDAN (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: adaptive immune response;Address;aggressive therapy;Alveolus;anti-fungal agents;Antigens;antiretroviral therapy;Blood;Breeding;C3HeB/FeJ Mouse;C57BL/6 Mouse;CD4 Positive T Lymphocytes;cell type;Cells;Central Nervous System Diseases;Central Nervous System Infections;Cessation of life;Characteristics;Clinical;clinical translation;Clinical Trials;co-infection;Containment;Cryptococcal Meningitis;Cryptococcosis;Cryptococcus;Cryptococcus neoformans;Cryptococcus neoformans infection;cytokine;Data;Death Rate;Development;Disease;Disease Outcome;Disease Progression;Environment;fungicide;Gene Expression Profile;Genes;Genetic Transcription;global health;Granuloma;Haplotypes;Histologic;HIV;HIV/AIDS;Human;human disease;human model;Immune;immune modulating agents;immune reconstitution;Immune response;Immunocompetent;Immunocompromised Host;immunodeficiency;immunomodulatory therapies;immunoregulation;Immunosuppression;Impairment;improved;in vivo Model;Individual;Infection;Infection Control;Inflammatory;Inhalation;Innate Immune Response;insight;Interferons;latent infection;Life;Lung;Macrophage;Maps;Measures;Mediating;Methods;Microscopy;Modeling;mortality;mouse model;Mus;Mycobacterium tuberculosis;Necrosis;Nervous System Trauma;new therapeutic target;novel;novel therapeutics;pathogen;pathogenic fungus;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Population;Predisposition;prevent;Production;pulmonary granuloma;recruit;Reproduction spores;Research;Resistance;response;Role;Signal Transduction;standard of care;Structure;T-Cell Depletion;Testing;therapeutic development;Time;time use;timeline;Tissues;tool;transcriptomics;Tuberculosis;World Health Organization

PROJECT_TITLE: Assessing the role of SP140 in enhanced resistance to Cryptococcus neoformans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-Y (20)]


ORG_DEPT: GENETICS

PHR: Project Narrative Osteoarthritis affects over 250 million people worldwide, and despite extensive research, a lack of under- standing of the molecular mechanisms underlying its risk factors has hindered the development of effective treatments. This study aims to identify novel genetic variants and splicing events that influence osteoarthritis risk by correlating genetic background, splicing patterns, and disease status. The results of this study are expected to provide new genes and pathways for future research and therapeutic development.

PI_NAMEs: BYUN, SEYOUN  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Affect;Alternative Splicing;arthropathies;Biological Assay;Cartilage Matrix;causal variant;cell type;Chondrocytes;Chromosome Mapping;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Complex;Data;Degenerative polyarthritis;Development;Disease;Disease Progression;disorder risk;Drug Targeting;effective therapy;Environmental Impact;Environmental Risk Factor;Event;Femur;Fibronectins;Gene Expression;gene function;Genes;Genetic;genetic variant;Genetic Variation;genome wide association study;genome-wide analysis;Hour;Human;human disease;Individual;Knee joint;Linkage Disequilibrium;Maps;Messenger RNA;Molecular;Nature;novel;Ontology;Operative Surgical Procedures;Outcome;Pathogenesis;Pathway interactions;Pattern;Persons;Phenotype;prevent;protein function;Protein Isoforms;Quantitative Trait Loci;Replacement Arthroplasty;Research;research and development;response;Rest;Risk;Risk Factors;risk variant;RNA Splicing;Role;Signal Transduction;Spliced Genes;Stimulus;System;Testing;therapeutic development;Tissues;tool;Transcript;Untranslated RNA;Validation;Variant;Work

PROJECT_TITLE: The effect of genetic variation on mRNA splicing in chondrocytes responding to cartilage matrix damage

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE (unchanged from Parent R37) Plasticity is emerging as a crucial hallmark of advanced cancer, but the molecular mechanisms that enable dynamic cancer cell adaptation to the stresses of metastasis are not understood. We will leverage patient samples, organoids, and insights we have generated to define key epigenetic nodes that determine the emergence of regenerative plasticity in MetSCs, and define the phenotypic consequences of transcriptional reprogramming during metastatic outgrowth. Results will define mechanisms of cancer progression and identify putative therapeutic targets to limit regenerative plasticity, with the potential to impact clinical outcomes.

PI_NAMEs: GANESH, KARUNA  (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: 3' Untranslated Regions;Adherens Junction;Advanced Malignant Neoplasm;BFU-E;Binding;cancer cell;cancer stem cell;Cell Cycle;Cells;Cessation of life;Chromatin;Clinical;Colitis;Colorectal Cancer;derepression;Development;E-Cadherin;Elements;Epigenetic Process;epithelial stem cell;Epithelium;Family;Genes;Genetic Transcription;Homeostasis;Impairment;insight;intestinal epithelium;Intestinal Neoplasms;Intestines;LGR5 gene;Lymphocyte;Maintenance;Malignant Neoplasms;Mediating;member;Molecular;mRNA Transcript Degradation;Muscle;Natural regeneration;Neoplasm Metastasis;neoplastic;Neural Cell Adhesion Molecule L1;Neurons;Oncogenes;Organoids;Outcome;Parents;Patients;Phenotype;Physiological;progenitor;Proliferating;regenerative;regenerative cell;Regulation;repaired;Resistance;response;restoration;RNA-Binding Proteins;Sampling;self-renewal;stem cell self renewal;stem cells;stemness;Stress;Structure;therapeutic target;tissue regeneration;Tissues;transcriptional reprogramming;tumor;tumor initiation;tumor progression;wound healing;ZFP36L2 gene

PROJECT_TITLE: Dissect the molecular mechanism of ZFP36L2-mediated cell fate plasticity

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Arthritis;Bioengineering;Dental, Oral, and Craniofacial Disease;Prevention;Regenerative Medicine;Temporomandibular Muscle/Joint Disorder (TMJD);Transplantation

ORG_CITY: PITTSBURGH

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: This proposal describes work in which a biologic scaffold composed of mammalian extracellular matrix will be used as an inductive scaffold for the in vivo generation of the temporomandibular joint disc. This inductive template will stimulate the rapid endogenous formation of a fibrocartilaginous disc that closely mimics the structure, composition and function of native disc material. The proposal will provide the first safe treatment following disc removal, improving outcomes for patients by preventing joint damage from long term bone-on-bone articulation.

PI_NAMEs: ALMARZA, ALEJANDRO JOSE (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: 3 year old;Address;Adolescent;Allografting;Anatomy;Animals;Anterior;Arthritis;Articulation;Autologous Transplantation;Biochemistry;Biological;bone;canine model;Clinical;clinical translation;clinically relevant;Complex;Dermis;Development;disc regeneration;Effectiveness;Environment;Etiology;Excision;Exhibits;Extracellular Matrix;Face;Family suidae;fat grafting;Fatty acid glycerol esters;FDA approved;Female;Fibrocartilages;functional outcomes;Generations;Goals;Goat;Growth;Histology;Hour;Human;Implant;implantation;improved outcome;in vivo;Inflammation;joint injury;Joints;male;Mastication;mature animal;Mechanics;migration;Modeling;Motion;Operative Surgical Procedures;Outcome;Pathogenicity;Pathologic;Pathology;Patient-Focused Outcomes;Patients;porcine model;prevent;Property;Replacement Therapy;Research;Rotation;scaffold;Secure;skeletal;Small Intestinal Submucosa;Structure;Structure of articular disc of temporomandibular joint;Study models;Surface;Surgical Management;Technology;Temporomandibular Joint;Testing;therapeutically effective;Time;tissue regeneration;Tissues;Translations;Work;Zygomatic Arch

PROJECT_TITLE: TMJ Disc Regeneration

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: ANN ARBOR

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE To understand the mechanisms of acute and long-term antiviral antibody responses elicited by invading pathogens or vaccines would be useful for the design of vaccines. This project aims to study mechanisms of B cell responses to virus-like particulate antigens, or mock viral particles, and provide training to a minority PharmD/PhD candidate. The successful completion of this project will fill in a gap in our knowledge regarding the initiation of antiviral antibody responses and prepare the candidate for the next step of his career.

PI_NAMEs: CHENG, WEI  (contact);ZIKHERMAN, JULIE

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Acute;Animals;Anti-viral Response;Antibody Response;Antigens;B-Lymphocytes;Biophysics;career;Cells;density;Doctor of Pharmacy;Doctor of Philosophy;Encapsulated;Ensure;Generations;Genetic Materials;Germ Lines;In Vitro;in vivo;Individual;Invaded;Knowledge;live cell imaging;Maintenance;Membrane Proteins;Minority;Modeling;Mus;next generation;Nucleic Acids;particle;Particulate;pathogen;Pharmacologic Substance;Proteins;response;Science;single molecule;Structure;success;Surface;System;Toll-like receptors;Training;Vaccine Design;Vaccines;Viral;Viral Antibodies;Viral Genome;Virion;Virus;Virus Diseases

PROJECT_TITLE: Mechanisms of B Cell Responses to Particulate Antigens


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Liver Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Differentiation is a fundamental process evident in a variety of cell states and transitions. Differentiation is a common feature in tumors, which is most pronounced in colorectal cancer, a vexing health problem. We seek to elucidate how LIN28B, an mRNA binding protein, fosters differentiation in colorectal cancers and concurrently, promote metastasis in this differentiated state.

PI_NAMEs: RUSTGI, ANIL K (contact)

PROJECT_TERMS: Address;Admixture;adult stem cell;Attenuated;Bar Codes;Binding Proteins;cancer site;Cell Cycle;Cell Differentiation process;cell growth regulation;Cell Physiology;Cell-Cell Adhesion;Cells;Cellular Metabolic Process;Circulation;Classification;claudin-1 protein;colon cancer cell line;Colon Carcinoma;Colonic Adenoma;Colorectal Cancer;colorectal cancer metastasis;Complex;Data;Dependence;Development;Distant;Embryo;embryonic stem cell;Endowment;Equilibrium;Extravasation;Fibroblasts;Fostering;gain of function;Gene Expression;Genetic;Genetic Engineering;Health;Homeostasis;Human;Human Engineering;Hybrids;Implant;in vivo;induced pluripotent stem cell;Injections;innovation;insight;intestinal epithelium;Invaded;knock-down;Liver;loss of function;Maintenance;Malignant - descriptor;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Mediating;Messenger RNA;metastatic colorectal;Metastatic Neoplasm to the Liver;Modeling;Molecular;mouse model;Mus;mutant;Mutation;Neoplasm Metastasis;neoplastic cell;NOTCH3 gene;novel;novel marker;Oncogenic;Organ;Outcome;overexpression;pharmacologic;Phenotype;Physiological;Play;pluripotency;pluripotent stem cell differentiation;Portal vein structure;Process;programs;Proliferating;Property;Publishing;regeneration following injury;Regulation;RNA-Binding Proteins;Role;Scheme;Signal Transduction;single-cell RNA sequencing;stem cell differentiation;stem cell division;Therapeutic;Tight Junctions;Totipotency;TP53 gene;transcription factor CDX2;transcriptome sequencing;tumor;Tumor Cell Invasion;tumor heterogeneity;tumor progression;tumorigenesis

PROJECT_TITLE: The Role of Cancer Associated Fibroblasts in LIN28B mediated Colorectal Cancer Metastasis


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Prostate Cancer;Urologic Diseases

PHR: PROJECT NARRATIVE Advanced lethal prostate cancer (PC) exhibits high chromosomal instability (CIN), yet the role of CIN in PC remains poorly understood. This proposal will investigate how CIN shapes transcriptional reprogramming and gene bookmarking, identify new proteins and mechanisms of CIN adaptation, and study CIN impact on the immune cell microenvironment in advanced PC. Combining epigenomics, transcriptomics, proteomics, high- resolution microscopy, and genetics in in vitro and in vivo models our studies will help define novel PC vulnerabilities arising with CIN and uncover new targetable mechanism that may improve PC patients outcomes.

PI_NAMEs: RODRIGUEZ-BRAVO, VERONICA  (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: Acute;advanced disease;advanced prostate cancer;American;Androgen Receptor;anti-tumor immune response;ATAC-seq;Biology;Breast Cancer Cell;Cancer Biology;Cancer Etiology;Cell Compartmentation;Cell division;Cell Line;Cell Nucleus;Cell Reprogramming;Cell Survival;Cells;Centrosome;Cessation of life;chemical genetics;chemotherapy;ChIP-seq;Chromatin;Chromosomal Instability;Clinical;Coculture Techniques;cofactor;Coupled;Coupling;Cytokinesis;Data;Dedications;Disease;DNA;driving force;Epigenetic Process;epigenomics;Exhibits;Functional dependence;GATA2 transcription factor;Genes;Genetic;Genetic Models;Genetic Transcription;Genetically Engineered Mouse;Heterogeneity;Immune;Immunologics;Immunotherapy;improved;In Vitro;in vivo;in vivo Model;Inflammatory;insight;Knock-in;Link;Maintenance;male;Malignant neoplasm of prostate;Malignant Neoplasms;Metastatic Prostate Cancer;micronucleus;Microscopy;Mitotic;Molecular;mouse model;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;novel therapeutics;Pathway interactions;Patient-Focused Outcomes;pharmacologic;Phosphotransferases;pre-clinical;Process;programs;prostate cancer cell;Prostatic Neoplasms;Proteins;Proteomics;Refractory;Regulation;Reporting;Resistance;Resolution;response;restraint;Role;RPS27 gene;Shapes;Signal Transduction;Stimulator of Interferon Genes;System;targeted treatment;taxane;Testing;Therapeutic;therapeutic target;therapy resistant;Time;transcription factor;transcriptional reprogramming;transcriptomics;treatment strategy;tumor;tumor diagnosis;Tumor Immunity;Tumor Promotion;Tumor-infiltrating immune cells;Up-Regulation

PROJECT_TITLE: Investigating the impact of chromosomal instability on prostate cancer aggressiveness

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-D (02)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Immigrants experience significant health disparities which are exacerbated by a heavy stress burden which in turn affects the epigenetic profiles of the immune system leading to chronic diseases. Ethiopians form one of the largest groups of African immigrants in the US, yet this is the first study of this kind among Ethiopian American immigrants. This study will quantify cumulative stress burden and determine DNA methylation associated with stress among Ethiopian American immigrants providing new insight to address health disparities among the steadily increasing US immigrant populations.

PI_NAMEs: MERSHA, TESFAYE B. (contact);VAUGHN, LISA MICHELLE

PROGRAM_OFFICER_NAME: LAI, GABRIEL Y

PROJECT_TERMS: Address;Adverse effects;Affect;African;Age;American;Anxiety;Area;Automobile Driving;Behavioral;bilingualism;Biological;Biological Markers;biomarker development;biopsychosocial;Black race;Buffers;Cardiovascular Diseases;Child;Chronic;Chronic Disease;Cities;Clinical;Clinical Data;Communities;Community Surveys;Country;Data Reporting;Development;Diabetes Mellitus;Disease;Disease Outcome;DNA Methylation;Environment;Epigenetic Process;epigenome;epigenomics;Ethiopia;Ethiopian;experience;Face;Faith;Funding;Generations;Genes;genome-wide;Goals;Health;health disparity;Heritability;Hypertension;Immigrant;Immigrant community;Immigration;Immune system;insight;Interdisciplinary Study;Intervention;Interview;Knowledge;Life Cycle Stages;Link;Measures;Mediation;Mental Depression;Mental disorders;Mental Health;Methylation;Midwestern United States;migration;Native-Born;Needs Assessment;novel;novel strategies;Obesity;Ohio;Outcome;Parents;Pathway Analysis;Pathway interactions;Patient Self-Report;Persons;physical conditioning;Play;Population;precision medicine;psychologic;Psychological Stress;psychosocial;Public Health;Reduce health disparities;resilience;Resources;Risk;Role;Sampling;secondary analysis;Site;social;Social support;Source;Stress;stressor;Subgroup;Surrogate Markers;therapy development;Translations;transmission process;Vulnerable Populations;Work

PROJECT_TITLE: Association of DNA Methylation and Stress in Immigrants

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Breast Cancer;Cancer;Dental, Oral, and Craniofacial Disease;Microbiome;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Fatigue is the most distressing symptom for individuals with breast cancer, but the physiological pathways associated with fatigue are unclear. This study will inform whether the oral microbiome, a biologic pathway posited to impact fatigue, is associated with fatigue in individuals with breast cancer receiving chemotherapy. The study findings will provide important information that can inform mechanistic underpinnings of fatigue and guide the development of tailored interventions to manage fatigue for individuals with breast cancer.

PI_NAMEs: SLACK, JULIA  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Academic Medical Centers;Address;Adjuvant Chemotherapy;Adverse effects;Affect;Aftercare;Biological;Biological Process;Cancer Survivorship;career;chemotherapy;Chronic Fatigue Syndrome;clinical data repository;Collection;common treatment;Communities;Consent;Data;debilitating symptom;demographics;Development;Disease;Distress;Ensure;experience;Family;Fatigue;Goals;Health;High Prevalence;Individual;Inflammatory;Information Systems;insight;Intervention;Investigation;Knowledge;Longitudinal Studies;Malignant Breast Neoplasm;Malignant Neoplasms;Mastectomy;Measurement;Microbe;microbial;microbiome;Modality;National Cancer Institute;novel;Oral;Oral Characters;oral microbiome;Outcome;Pathway interactions;Patient Outcomes Assessments;Patients;Personal Satisfaction;Persons;Physiological;Postoperative Period;Prevalence;programs;quality of life for cancer survivors;Research;Research Personnel;Sampling;Social Functioning;symptom management;symptomatic improvement;Symptoms;Taxon;Universities;Update;Work

PROJECT_TITLE: Exploring the Relationship Between the Oral Microbiome and Fatigue in Individuals with Breast Cancer: A Longitudinal Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (21)]


ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE As overdose among people experiencing homelessness surges, it is critically important to identify effective strategies to stem the tide of overdose deaths for this highly marginalized population. The proposed community-partnered study will use advanced epidemiological and data science methods together with qualitative interviews to rigorously examine the implementation and effectiveness of a novel, systemwide Harm Reduction Strategic Plan suite of interventions administered across homeless shelters in New York City. The study will produce new practice- and policy-relevant evidence to inform local and national programmatic and policy interventions, laying the groundwork for widespread implementation of place-based overdose prevention strategies to meet the unique needs of individuals experiencing homelessness, a population at disproportionate risk of overdose death.

PI_NAMEs: ALLEN, BENNETT  (contact);DORAN, KELLY

PROJECT_TITLE: CE24-013 - Community-based evaluation of a novel, system-wide harm reduction strategic plan for people experiencing homelessness in New York City

STUDY_SECTION_NAME: Special Emphasis Panel[ZCE1 AW (03)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_DEPT: PHYSIOLOGY

PHR: Pregnancy conditions such as prediabetes, obesity, and gestational diabetes mellitus can exacerbate maternal insulin levels causing changes such as placental inflammation, which can mal-program fetal metabolic tissues and predisposing the offspring to metabolic disease in childhood and adulthood. Yet, very little information is known about the role of insulin signaling in placental inflammation in the offspring of dams with hyperinsulinemia. We expect that the results from the proposed work will ultimately lead to new understanding of the effects of high maternal insulin during pregnancy on placental inflammation that may cause programming of metabolic disease, and this new knowledge could improve clinical management of patients, and thus improve women's reproductive health and pregnancy outcomes.

PI_NAMEs: ALEJANDRO, EMILYN  (contact)

PROGRAM_OFFICER_NAME: SILVA, CORINNE M

PROJECT_TERMS: Acceleration;Address;Adult;Award;Binding;Cells;Childhood;Clinical;Clinical Management;Data;detection of nutrient;Development;Environmental Risk Factor;fetal;Fetal Growth;Fetus;FRAP1 gene;Genetic;Gestational Diabetes;Glucose;Glucose Intolerance;glucose tolerance;Growth Factor;Health;Hormones;Hyperglycemia;Hyperinsulinism;Immune;improved;Inflammation;Inflammatory;Insulin;Insulin Receptor;insulin signaling;Insulin-Like-Growth Factor I Receptor;Knowledge;Link;Metabolic;Metabolic Diseases;Metabolic dysfunction;Molecular;Mothers;Non-Insulin-Dependent Diabetes Mellitus;Nutrient;Nutrient availability;Obesity;offspring;Outcome;Patients;Phase;Placenta;Placentation;Prediabetes syndrome;Predisposition;Pregnancy;Pregnancy Outcome;Pregnant Women;programs;receptor;Risk;Role;Signal Transduction;success;Testing;Tissues;Weight Gain;women's reproductive health;Work

PROJECT_TITLE: Placental Insulin Signaling and mTOR Nutrient-Sensing Programming of Offspring Metabolic Health

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: CHICAGO

ORG_DEPT: PATHOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative This project seeks to identify and develop novel small molecule degraders of FoxP3 to target Tregs, diminishing Treg suppressive function, and increase the anti-tumor immune response. Our short-term goal is to provide rationale for targeting FoxP3 by small molecular glue degraders; and our long-term goal is to develop immunomodulatory therapeutics by harnessing the ubiquitin pathway.

PI_NAMEs: TANG, AMY  (contact)

PROJECT_TERMS: anti-cancer;anti-PD-1;anti-PD-1/PD-L1;anti-PD-L1;anti-tumor immune response;Antitumor Response;Binding;cancer therapy;Cause of Death;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell Line;Cell Physiology;cell type;Cells;Chemicals;clinical prognosis;Complex;cytotoxicity;Data;design;Development;Diagnosis;Disease remission;Dose;efficacy evaluation;Enzymes;Flow Cytometry;FOXP3 gene;Future;Genetic;Genetic Transcription;Glues;Goals;Human;immune modulating agents;Immune response;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;Laboratories;Lead;Libraries;Malignant Neoplasms;Modeling;Molecular;mouse model;multicatalytic endopeptidase complex;Mus;novel;novel therapeutics;Nuclear;Pathway interactions;Patients;Post-Translational Protein Processing;protein expression;Proteins;Regulation;Regulatory T-Lymphocyte;Reporter;response;Role;small molecule;small molecule libraries;Specificity;Substrate Interaction;System;Testing;Therapeutic;therapeutic target;Time;Toxic effect;transcription factor;Treatment Efficacy;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;Work

PROJECT_TITLE: Identification of molecular glues targeting FoxP3 to modulate Treg suppressive function and enhance anti-tumor immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09C-Z (20)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: STANFORD

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Neuregulin-1β (NRG1) is a promising recombinant protein therapy for myocardial infarction (MI) which suffers from rapid loss of function during conventional intravenous administration, necessitating high dosing, repeated administration, and/or long treatment periods. In this study, I present the development and evaluation of a new engineered injectable liposome-crosslinked hydrogel for sustained NRG1 delivery into the infarcted myocardium. Success of this proposed study would enhance the outcomes of NRG1 therapy for MI and provide a novel approach for sustained, direct delivery of protein therapeutics into the heart.

PI_NAMEs: BAUGH, NEIL  (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Actins;Address;Affect;alpha Actin;angiogenesis;Animals;Anterior;Apoptosis;Arteries;Benzaldehyde;Bioethics;Blood capillaries;Blood specimen;Bolus Infusion;Cardiac;Cardiac Myocytes;cardiac repair;Cardiology;Catheters;Cause of Death;Cells;Chemistry;chemokine;Clinical Treatment;Coculture Techniques;Collaborations;Connexin 43;controlled release;crosslink;cytokine;density;design;Development;Dose;Drug Delivery Systems;Drug Kinetics;Echocardiography;Encapsulated;ENG gene;Engineering;Evaluation;Family;Female;Fibroblasts;Formulation;Gel;Half-Life;Hand;Heart;Heart Contractilities;heart function;Hour;Hyaluronic Acid;Hydrogels;Hydrogen Peroxide;Hypoxia;Immune response;improved;In Vitro;in vivo;Infarction;Injectable;Injections;Intravenous;intravenous administration;Intravenous infusion procedures;Left;Libraries;Ligation;light scattering;Link;Liposomes;loss of function;male;Maps;Measurement;Mentors;Methods;Modeling;Morphology;Motion;Myocardial Infarction;Myocardium;nanoparticle;Needles;Neuregulins;novel strategies;Outcome;PECAM1 gene;Performance;Persons;Pharmaceutical Preparations;pharmacokinetic model;phase II trial;Phenotype;PicoGreen;Plasma;pre-clinical;Pre-Clinical Model;pressure;prevent;Proliferating;Property;Proteins;Pump;Randomized;Rattus;Recombinant Proteins;Regenerative Medicine;response;Rheology;Rodent;Saline;Serum;Specificity;Sprague-Dawley Rats;Stains;Structure;success;Surface;Surgical sutures;Syringes;System;Therapeutic;therapeutic protein;Time;Tissues;Toxic effect;treatment duration;treatment effect;treatment group;Trichrome stain method;undergraduate student;United States;Universities;viscoelasticity;VWF gene;Work

PROJECT_TITLE: Liposome-crosslinked hyaluronic acid hydrogels with localized protein delivery for myocardial infarction therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (20)]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prostate Cancer;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Prostate cancer in African Americans exhibits distinctive features, including heightened aggressiveness, more widespread metastases, earlier onset, and elevated mortality rates compared to those in Caucasian Americans. This diversity supplement aims to provide support for a graduate student candidate, facilitating the exploration of an overlooked yet significant aspect: the development and enhancement of computerized decision support tools to elevate the performance of prostate cancer diagnosis specifically for the African-American population.

PI_NAMEs: KIM, HARRISON ;SUNG, KYUNG HYUN  (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: 3-Dimensional;3D Print;African American;African American population;Alabama;Anatomy;Area;Artificial Intelligence;Biological;Blood;California;cancer diagnosis;cancer health disparity;Cancerous;Categories;caucasian American;Characteristics;Clinic;Clinical;clinically significant;Computer software;computerized;Data;Data Collection;Data Set;Death Rate;Dedications;deep learning model;Detection;detection method;Development;Diagnostic;early onset;Ensure;Ethnic Origin;Ethnic Population;Exhibits;Face;Funding;Goals;graduate student;Guidelines;histopathological examination;Histopathology;Image;Image Analysis;imaging biomarker;Imaging Techniques;improved;Incidence;indexing;Individual;Information Systems;Institution;interest;International;Lesion;Link;Location;Los Angeles;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Mann-Whitney U Test;Measurement;Medical Imaging;meetings;men;Methods;Modeling;Molds;Neoplasm Metastasis;non-invasive imaging;Operative Surgical Procedures;Pathologist;Pathology;Patient Recruitments;Patient Schedules;Patients;Performance;Perfusion;Physics;Positioning Attribute;Predictive Value;Prevalence;Process;Prospective cohort;Prostate;Prostatic Neoplasms;Protocols documentation;Pythons;quantitative imaging;Race;racial disparity;Radical Prostatectomy;radiologist;Radiology Specialty;recruit;Reporting;Research;Research Activity;Retrospective cohort;risk stratification;ROC Curve;Scheme;Screening for Prostate Cancer;Sensitivity and Specificity;Slice;Slide;Societies;Specificity;Specimen;Standardization;Structure of base of prostate;Supervision;support tools;Testing;timeline;Tissues;Training;tumor;tumor microenvironment;United States;Universities;Update;urologic;Urology;Work

PROJECT_TITLE: Diversity Supplements for Imaging Research in Prostate Cancer Health Disparities


ADMINISTERING_IC: NR

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Maternal Health;Maternal Morbidity and Mortality;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

PHR: Project Narrative Despite the clear link between intimate partner violence (IPV) and adverse maternal health outcomes, including maternal mortality, IPV is understudied in maternal health research. This R25 grant proposal seeks to bridge this gap by developing, implementing, and evaluating a comprehensive web-based research education program and resource toolkit to equip maternal health researchers with the essential skills to effectively measure and address IPV in their research. Empowering maternal health researchers with these skills will build their capacity to generate translatable evidence-based solutions to address the intersection of IPV and maternal health, thus strengthening the ability of health professionals to provide comprehensive care and, ultimately, contributing to the reduction of maternal mortality and IPV among vulnerable populations.

PI_NAMEs: WILLIAMS, JESSICA ROBERTS (contact)

PROGRAM_OFFICER_NAME: GIVENS-BRADLEY, SHANNON SHAREE

PROJECT_TERMS: Address;Adolescent;Adult;adverse outcome;Affect;Aggressive behavior;Applications Grants;Area;Awareness;Behavior;Black race;Cancer Education Grant Program;Cause of Death;Characteristics;Comprehensive Health Care;Data;Decision Making;design;Development;Dimensions;Education;education research;Educational Curriculum;Educational Models;Educational Status;Effectiveness;effectiveness research;empowerment;Enrollment;Ensure;Ethics;Evaluation;Event;evidence base;experience;Faculty;Feedback;formative assessment;Funding;global health;Grant;Guidelines;Health Professional;high risk;Homicide;Hour;improved;Instruction;intimate partner violence;Knowledge;Learning;Link;Maternal Health;Maternal Mortality;maternal risk;Measurement;Measures;online resource;Online Systems;Outcome;Participant;patient engagement;Play;Population;Pregnancy;Process;process evaluation;programs;Protocols documentation;public health research;Research;Research Personnel;Resources;Risk;Role;Safety;Sampling;satisfaction;skills;Structure;theories;Time;tool;Training Programs;Vulnerable Populations;webinar;Work

PROJECT_TITLE: Bridging Research Gaps: Building Capacity for Measuring and Addressing Intimate Partner Violence (IPV) in Maternal Health Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-H (53)]


ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Project Narrative Antibiotics severely alter the gut microbiome producing a state of microbial imbalance called dysbiosis. How dysbiosis affects cancer progression is largely unknown. This project will expand our understanding of the crosstalk between the gut microbiome, the tumor microenvironment, and cellular immunotherapy during antibiotic-induced dysbiosis.

PI_NAMEs: DINGS, RUUD P.M. (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Acceleration;Affect;Antibiotic Therapy;Antibiotics;Arkansas;Cancer Patient;career;CD8-Positive T-Lymphocytes;Cell Adhesion Molecules;Cellular immunotherapy;Clinical;clinically relevant;combat;commensal bacteria;congenic;Data;Defect;Development;Distal;diversity and inclusion;Doctor of Medicine;Doctor of Philosophy;doctoral student;Dose;dysbiosis;Educational process of instructing;Effectiveness;effector T cell;Endothelial Cells;Endothelium;Extravasation;fecal transplantation;Foundations;Future;Goals;gut microbiome;gut microbiota;Health;Human;Immune;Immune checkpoint inhibitor;Immune response;Immune system;immunogenic;Immunologic Surveillance;immunoregulation;Immunosuppression;Immunotherapy;improved;Incidence;Infection;Intercellular adhesion molecule 1;ionization;Ionizing radiation;leukocyte activation;Leukocyte Trafficking;Leukocytes;Lung Carcinoma;Malignant Neoplasms;Medical;medical specialties;Melanoma;Melanoma Tumor;Mentors;Modality;Modeling;Molecular;Morbidity - disease rate;mouse model;Mus;Neoadjuvant Therapy;neoplasm immunotherapy;next generation;Nude Mice;pathogenic bacteria;Patients;Physicians;Publishing;Radiation;Radiation Oncology;Radiation therapy;Research;response;role model;Science;Scientist;Solid Neoplasm;success;T cell infiltration;T cell therapy;T-Lymphocyte;therapy development;trafficking;Treatment Efficacy;treatment strategy;tumor;Tumor Immunity;tumor microenvironment;tumor progression;Universities;unpublished works;Work

PROJECT_TITLE: Improvement of cellular immunotherapy during dysbiosis - A. A. Brint Supplement


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Preterm, Low Birth Weight and Health of the Newborn;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: NARRATIVE There is significant health care disparity in access to genomic medicine among sick newborns in broad areas of Texas. Our proposed work will provide evidence of the impact of a virtual platform for telegenetic consultation service with low-cost genomic sequencing to reduce this disparity, as well as determine best practices for implementation.

PI_NAMEs: LALANI, SEEMA R;LEE, BRENDAN  (contact);PEREIRA, STACEY

PROGRAM_OFFICER_NAME: RIDER, RENEE ANNE

PROJECT_TERMS: Academic Medical Centers;access disparities;Address;Adoption;Area;Back;Basic Science;Biological Assay;care providers;Caring;Cities;Clinical;clinical decision-making;clinical research site;Cluster randomized trial;college;Communities;Consultations;cost;Counseling;Democracy;Development;Diagnosis;Diagnostic;diagnostic strategy;digital divide;Disease;disparity reduction;Education;effectiveness evaluation;Electronic Health Record;Environment;Equity;ethnic minority;evaluation/testing;Exposure to;Failure;Family;family support;Fibroblasts;Generations;Genetic;Genetic Diseases;genetic disorder diagnosis;Genetic Predisposition to Disease;Genetic Services;Genome;genome sequencing;genomic data;Genomic medicine;Genomics;Genotype;Geography;Goals;Health;health care disparity;Health Personnel;Health Resources;Health Services Accessibility;healthcare community;Hispanic;Home;Hospitalization;Hospitals;Human;human DNA;Human Genetics;human model;implementation evaluation;Improve Access;improved;Infant Care;Infrastructure;innovation;inpatient service;Inpatients;Intervention;Knowledge;Language;Maintenance;Medical;Medical Genetics;Medicine;metabolomics;Mexico;minority communities;model organism;Modeling;Molecular Diagnosis;molecular diagnostics;multiple omics;Neonatal Intensive Care Units;neonate;Newborn Infant;novel sequencing technology;Online Systems;Outpatients;Patient Education;patient engagement;Patients;peer;personalized care;personalized medicine;Phenotype;point of care;poor communities;Population;prevent;Program Development;Provider;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;recruit;Reduce health disparities;remote communities;Remote Consultation;remote location;Reporting;Research;research clinical testing;Resources;service delivery;Services;Site;skin biopsy;Spanish/English;Structure;Support System;Tablets;Technology;telegenetics;telehealth;Testing;Texas;tool;Training;transcriptome sequencing;Translating;Travel;treatment as usual;trial design;underserved area;underserved community;United States;United States National Institutes of Health;Variant;virtual healthcare;virtual platform;Whole Blood;whole genome;Work

PROJECT_TITLE: MAGNET: MAKING GENOMICS ACCESSIBLE FOR NEWBORNS IN TEXAS

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-W (M4)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The proposed K23 supplement aims to evaluate the feasibility and acceptability of a linguistically adapted mobile health parenting stress intervention for caregivers of legally youth, a population with high rates of substance use and low rates of treatment engagement. Findings will contribute to the public health and juvenile legal fields by providing crucial information about the equitable and ethical use of mobile health interventions with Spanish speaking caregivers of legally involved youth. The proposed work will also expand the investigator's capacities as an independent health services investigator striving to improve behavioral health outcomes for marginalized youth and families by advancing the linguistic and cultural accessibility of her work.

PI_NAMEs: FOLK, JOHANNA BAILEY (contact)

PROGRAM_OFFICER_NAME: MULFORD, CARRIE FRIED

PROJECT_TERMS: acceptability and feasibility;Adolescent;behavioral health;bilingualism;California;caregiver interventions;Caregivers;Cellular Phone;Child Rearing;Clinical Trials Design;Collaborations;Communities;court;design;detention center;digital health;efficacy testing;English Language;Equity;Ethics;ethnoracial;Exclusion;Face;Family;family support;Foundations;Funding;Goals;Health;Health Services;Hybrids;Imprisonment;improved;Inequity;Informatics;innovation;Institutional Review Boards;interest;Intervention;Jail;Justice;juvenile justice system;Language;Latinx;Latinx population;Legal;Legal system;Linguistics;marginalization;mHealth;mhealth interventions;mindfulness-based stress reduction;Mobile Health Application;National Institute of Drug Abuse;Outcome;Parents;peer;Population;Prisons;programs;Public Health;Published Comment;Research;Research Design;Research Personnel;Research Support;Residential Facilities;Residential Treatment;Resources;response;San Francisco;Schools;Spanish;Spanish/English;Strategic Planning;Stress;stress reduction;substance use;substance use treatment;System;Testing;Training;Translating;Translations;treatment center;Universities;Work;Youth

PROJECT_TITLE: Reducing Parenting Stress to Facilitate Justice-Involved Youth's Treatment Engagement

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Breast Cancer;Cancer;Estrogen;Genetics;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: CHEMISTRY

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Project Narrative  Triple-negative breast cancer (TNBC) is the second leading cause of cancer death in American women and is commonly diagnosed in Black women under forty. There is currently no targeted therapy for TNBC. The overexpression of androgen receptors (ARs) and histone lysine demethylases (KDMs) are vital to the viability of TNBC. Interestingly, AR overexpression is the most important driver of prostate cancer (PCa). This Diversity Supplement application proposed to test the hypothesis that antiandrogen drugs used to treat PCa, when effectively integrated into KDM inhibiting moieties, could furnished novel new treatment modality for TNBC.

PI_NAMEs: OYELERE, ADEGBOYEGA  (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: 4T1;American;Androgen Antagonists;Androgen Receptor;antagonist;Apoptosis;Bioinformatics;black women;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer therapy;Breast Carcinoma;Cancer Cell Growth;Cancer Etiology;cancer subtypes;Cell Survival;Cells;Cessation of life;Chemoprevention;Clinical;clinical development;Compensation;cytotoxic;cytotoxicity;Data;design;Diagnosis;Drug Kinetics;Drug resistance;Drug usage;Endocrine;Epidermal Growth Factor Receptor;Epigenetic Process;ESR1 gene;Estrogen Receptor Modulators;Estrogen Receptors;Exhibits;Family;FDA approved;Fulvestrant;Functional disorder;gene repression;Heterochromatin;Histone Deacetylase;histone methyltransferase;Histones;Hormones;Human;In Vitro;in vivo;Incidence;inhibitor;insight;Investigation;Iron Chelation;KDM5B gene;Lead;lead candidate;Lysine;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;MDA MB 231;Measures;Mediating;Medical;member;Modality;Modeling;mouse model;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutics;overexpression;Oxidases;paralogous gene;parent grant;Patients;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Positioning Attribute;preclinical study;Progesterone Receptors;Property;Proteins;Reader;receptor expression;Receptor Signaling;Relapse;Resistance;Role;Signal Transduction;success;T47D;Tail;Tamoxifen;targeted treatment;Testing;Therapeutic Agents;Therapeutic Intervention;Toxicology;triple-negative invasive breast carcinoma;tumor;tumor growth;Veins;Woman;Women's mortality;Xenograft procedure

PROJECT_TITLE: Reposition and Optimization of Deferiprone for Breast Cancer Therapy

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Behavioral and Social Science;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homicide and Legal Interventions;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE This program will equip researchers with knowledge and skills of big data analytics and digital health technologies for more accurate measurement of intimate partner violence (IPV) and accessible, trauma- informed interventions with IPV survivors of underrepresented pregnant/postpartum women to reduce maternal morbidity and mortality.

PI_NAMEs: KIM, SANGMI  (contact);XIAO, RAN

PROGRAM_OFFICER_NAME: BOWEN, MARY ELIZABETH

PROJECT_TERMS: Adolescence;Advocate;Big Data;Big Data Methods;Black race;career;Cause of Death;Collaborations;Communication;Communities;complex data;complex modeling;cost;Country;COVID-19 pandemic;Data;data literacy;data mining;Data Science;design;digital;digital health;digital tool;E-learning;Education;Education Projects;Educational Curriculum;Educational process of instructing;Effectiveness;Electronic Health Record;Ensure;Ethics;ethnic minority;Etiology;experience;Exposure to;Family;Feedback;Fostering;Friends;Generations;Goals;Grant;Guns;hands on instruction;Health;health inequalities;health information technology;Health Personnel;Health Sciences;Health Technology;High Risk Woman;Homicide;Hour;Human Resources;Hybrids;improved;innovation;Institution;Interdisciplinary Study;intersectionality;Intervention;intimate partner violence;Knowledge;Learning;Manuscripts;maternal morbidity;Maternal Mortality;Measurement;Measures;Mentorship;mobile application;Modeling;Mothers;Murder;next generation;Participant;Patient Recruitments;Persons;Police;Population;Postpartum Period;Postpartum Women;Predisposition;Pregnancy;Pregnant Women;prevent;Prevention;Prevention strategy;Privacy;Process;programs;protective factors;racial minority;recruit;Research;Research Personnel;Research Technics;Research Training;Resources;Risk;Safety;Sampling;School Nursing;screening;Security;Services;Shame;Shelter facility;skills;social health determinants;social media;social stigma;socioeconomic disadvantage;Source;Subgroup;Support System;surveillance data;Surveys;Survivors;Targeted Research;Teen Dating Violence;tool;Training;Transportation;Trauma;Universities;Violence;virtual;Visualization;White Women;Woman;Women's Health;Women's prevalence;Work;working group

PROJECT_TITLE: Trauma-informed data science to prevent intimate partner violence among pregnant and postpartum women


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: NARRATIVE MDM2 and its numerous isoforms are key regulators of the expression and function of the p53 gene, a critical tumor suppressor that prevents inappropriate cell growth and proliferation. The proposed research will study the molecular connection between DNA damage, MDM2 isoform switching, p53, and cancer. Unraveling this pathway could lead to the discovery of novel therapeutic intervention points and thus be a crucial stepping-stone for cancer drug discovery.

PI_NAMEs: CHANDLER, DAWN S (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Adult;Alanine Transaminase;Alternative Splicing;Antineoplastic Agents;Astrocytoma;Automobile Driving;Binding;Binding Proteins;Bioinformatics;Biological Assay;Biology;Biophysics;Breast;Cancer Biology;cancer therapy;cancer type;cell growth;Cell Line;Cell Proliferation;cell type;Cells;Cellular Stress;Chemistry;chemotherapeutic agent;Childhood Glioma;combinatorial;Complex;Coupled;Data;design;Disease;DNA Damage;Dominant-Negative Mutation;drug discovery;Engineering;Event;Excision;exon skipping;Exons;Future;gene-editing approach;Generations;Genetically Engineered Mouse;Genome;Genotoxic Stress;genotoxicity;Glioma;Goals;High-Throughput Nucleotide Sequencing;Human;In Vitro;industry partner;Knowledge;Length;liposarcoma;Lung;Lymphoma;Malignant Childhood Neoplasm;Malignant Neoplasms;MDM2 gene;Measures;Mechanics;Mediating;Methodology;Methods;MicroRNAs;Modality;Modeling;Molecular;mouse model;mRNA Precursor;Mus;Mutation;novel;novel therapeutic intervention;Nuclear;Nuclear Protein;Nuclear RNA;Oligonucleotides;Oncogenic;Outcome;Ovary;overexpression;Pathway interactions;Pharmacologic Substance;Phenotype;Play;Positioning Attribute;prevent;Primary Neoplasm;Property;Protein Isoforms;Proteins;Publishing;Regulation;Regulatory Element;Repression;Research;response;Rhabdomyosarcoma;RNA;RNA Biochemistry;RNA metabolism;RNA Processing;RNA Sequences;RNA Splicing;RNA-Binding Proteins;Role;Sampling;Stress;System;Technology;Testing;Therapeutic;Therapeutic Intervention;therapy design;TP53 gene;tumor;tumor progression;Tumor Suppressor Proteins;tumorigenesis;tumorigenic;Variant;Viral;Work;Xenograft procedure

PROJECT_TITLE: Mdm2 Alternative Splicing in DNA Damage and Cancer


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Colorectal cancer is one of the most incident cancers in the United States. African Americans have higher incidence of colorectal cancer compared to non-Hispanic whites, with worse prognosis. This study will identify biologic pathways that differ in colorectal cancers that arise in African Americans.

PI_NAMEs: PURRINGTON, KRISTEN S.;ROZEK, LAURA  (contact);STOFFEL, ELENA MARTINEZ

PROGRAM_OFFICER_NAME: MOMIN, BEHNOOSH RAMJI

PROJECT_TERMS: Accounting;Adjuvant Therapy;advanced disease;Africa;African American population;African ancestry;Age;aged;Area;Behavioral;Binding Sites;bioinformatics pipeline;Biological;Biology;Black Populations;BRAF gene;cancer health disparity;cancer subtypes;cancer survival;carcinogenicity;CCNE1 gene;Cells;Characteristics;Classification;Clinical;Clonal Evolution;cohort;Colon;Colonoscopy;Colorectal;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;colorectal cancer screening;Complex;Consensus;CTNNB1 gene;Custom;Data;Databases;Death Rate;design;Diagnosis;differential expression;dimension reduction;Disease;Disease Progression;DNA Methylation;Drug resistance;drug sensitivity;Environmental Risk Factor;Epigenetic Process;Event;Frequencies;Gene Expression Profile;Gene Mutation;Gene set enrichment analysis;Genes;Genetic;Genomics;Geographic Locations;Goals;high risk;Housing;improved;Incidence;Income;Individual;Insurance Coverage;Investigation;Malignant Neoplasms;Marital Status;Methods;Methylation;Mismatch Repair;Molecular;mortality;mutant;Mutation;Natural Selections;Not Hispanic or Latino;novel;open source tool;Operative Surgical Procedures;Outcome;Pathogenesis;Pathway interactions;Pattern;people of color;personalized medicine;Phenotype;Phylogenetic Analysis;Population Group;Population Heterogeneity;pressure;Prognosis;racial difference;racial disparity;racial diversity;Recording of previous events;Research;Sampling;screening;sex;single-cell RNA sequencing;Site;social disparities;social factors;Socioeconomic Factors;survival disparity;transcription factor;Trees;tumor;Tumor Biology;tumor progression;Tumor Subtype;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Aggressive colorectal cancer subtypes and social disadvantage in a racially diverse cohort

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Human Genome;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE Pediatric high-grade gliomas (pHGG), which include diffuse midline glioma (DMG), are among the most lethal of all pediatric cancers, with survival rarely exceeding two years. Mutations in the histone variant H3.3 and loss of ATRX are two of the most common mutations in pHGG, but it is not known how the two interact with each other to impact re-expression of early brain development genes. This proposal aims to look at how the two different histone mutations interplay with ATRX loss to affect developmental gene expression and tumor formation.

PI_NAMEs: MESSINGER, DANA  (contact)

PROJECT_TERMS: Address;Affect;ATRX gene;Behavior;Binding;Brain;Catalytic Domain;cell growth;Cell Line;Cell Proliferation;Cells;Childhood Glioma;chromatin remodeling;Cleavage Under Targets and Release Using Nuclease;Clinical;Complex;Data;design;Development;Developmental Gene;diffuse midline glioma;Electroporation;Embryo;Epigenetic Process;Etiology;Exhibits;EZH2 gene;Fibroblasts;Functional disorder;gain of function mutation;Gene Expression;gene repression;Genes;Genetic Markers;Genome;Genomics;Glioma;Glycine;Goals;H3 K27M mutation;Histones;Impairment;in utero;in vitro Model;in vivo;insight;knock-down;Knowledge;loss of function mutation;Lysine;Malignant Childhood Neoplasm;Mediating;Messenger RNA;Methods;Methyltransferase;Mus;mutant;Mutation;neoplastic cell;nerve stem cell;novel;Oncogenic;Patients;Pattern;Play;Polycomb;prevent;Proteins;Repression;Role;stem cell biomarkers;stemness;Testing;Transcriptional Regulation;tumor;tumor growth;tumorigenic;Up-Regulation;Variant;Work

PROJECT_TITLE: The role of H3F3A and ATRX co-mutation in epigenetic dysregulation of developmental genes in pediatric high-grade glioma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09B-C (20)]


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Project Narrative As we age, physical activity becomes more important to maintain health and well-being. Interventions to support patients to be more active are not routinely incorporated into clinical practice and patients often do not meet national physical activity guidelines. In a sample of WTCHP participants with cancer, this project proposes to test the effectiveness and implementation of a brief motivational intervention to support physical activity.

PI_NAMEs: GINEX, PAMELA  (contact)

PROGRAM_OFFICER_NAME: YIIN, JAMES

PROJECT_TITLE: Effectiveness and Implementation of a Brief Motivational Intervention to Increase Physical Activity for World Trade Center Health Program Cancer Survivors

STUDY_SECTION_NAME: Special Emphasis Panel[ZOH1 LEE (52)]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: 1 Percutaneous lung biopsies (PLB) are a minimally invasive method for workup of suspicious lung nodules  2 with nearly 30,000 biopsies performed by interventional radiologists in the VHA between FY 2017-2022.  3 Between 5-15% of PLBs result in a severe pneumothorax requiring chest tube placement and frequently  4 inpatient care. Prior work found wide variation in hospital rates of severe pneumothorax, indicating sites with  5 better performance may have PLB practices that improve outcomes. The proposed mixed methods study will  6 1) interview interventional radiologists regarding best practices for patient selection and pneumothorax  7 prevention, 2) mine VHA electronic data to determine diagnostic yield and provider referral behavior, and 3)  8 integrate Aim 1 and 2 findings to identify best practices associated with low rates of severe pneumothorax and  9 high rates of meaningful diagnostic results. We will submit an HSR&D IIR proposal based on our pilot study 10 findings to establish consensus on PLB best practices and test implementation of these practices in the VHA.

PI_NAMEs: MULL, HILLARY JANE (contact)

PROJECT_TERMS: Algorithms;American College of Radiology;Area;Award;Behavior;Biopsy;Blood;Bronchoscopy;Calculi;cancer diagnosis;cancer risk;Caring;Characteristics;Chest Tubes;Chronic Obstructive Pulmonary Disease;Clinical Management;Community Healthcare;comorbidity;Complication;Consensus;Data;data integration;data mining;Data Science;Data Sources;data to knowledge;data warehouse;Decision Making;Detection;Diagnosis;Diagnostic;effectiveness measure;electronic data;evidence base;Evidence based practice;experience;Goals;Guidelines;Health Services Research;Homogeneously Staining Region;Hospitalization;Hospitals;Iatrogenesis;implementation trial;improved;improved outcome;Incidence;informatics tool;Information Systems;innovation;inpatient service;Intervention;Interview;Location;Lung;lung cancer screening;Lung CAT Scan;Lung nodule;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Methodology;Methods;minimally invasive;mortality;Needles;Nodule;novel;Operative Surgical Procedures;Outcome;Pathologic;Patient Selection;Patients;Pattern;Performance;Pilot Projects;Pneumothorax;Policies;Population;Positioning Attribute;prevent;Prevention;primary outcome;Principal Investigator;Procedures;programs;Provider;provider factors;radiologist;Radiology Specialty;recruit;Reporting;Research;Research Methodology;Risk;Risk Adjustment;risk stratification;risk/benefit ratio;Safety;Sampling;Science;Scientific Inquiry;screening program;sealant;Secondary to;Signs and Symptoms;Site;Smoking Behavior;Structure;structured data;System;Techniques;Testing;Text;text searching;trend;Variant;Veterans;Work

PROJECT_TITLE: Pilot Study to Assess Best Practices to Prevent Pneumothorax Following Lung Biopsy

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cardiovascular;Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Pediatric;Pediatric Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: Project Narrative We have identified 2.5-fold higher prevalence of doxorubicin-induced cardiotoxicity (DIC) in African American (AA) than European American survivors yet the biological basis of this racial disparity in DIC is poorly understood. We will use human induced pluripotent stem cell-derived cardiomyocytes derived from AA survivors to discover novel genetic variants for DIC and validate the mechanisms by which these genetic variants influence this potentially fatal drug complication. This knowledge will provide clinicians with a validated genomic tool to predict if a patient will experience DIC and a route to discover genotype-specific cardioprotective drugs.

PI_NAMEs: BURRIDGE, PAUL W. (contact);SAPKOTA, YADAV

PROGRAM_OFFICER_NAME: SHELBURNE, NONNIEKAYE F

PROJECT_TERMS: Adult;African American;Age;American;antagonist;Anthracycline;Antioxidants;Apoptosis;BCL2 gene;Biochemical;Biological;Biological Assay;Bioreactors;Blastoma;Body mass index;Calcium;cancer diagnosis;Cancer Patient;Candidate Disease Gene;Cardiac;Cardiac Myocytes;Cardiomyopathies;cardioprotection;Cardiotoxicity;CASP1 gene;CASP3 gene;CASP8 gene;CASP9 gene;Caspase;CD95 Antigens;Cell Death;Cell Death Induction;Cell Membrane Permeability;Cell Physiology;Cell Survival;Cells;Cessation of life;Chemicals;chemotherapy;Chest;Child;childhood cancer survivor;Chromatin;Clinical;clinical application;Clinical Data;clinical risk;cohort;college;Complementary DNA;Complex;Complication;Correlation Studies;cost effective;cost efficient;CRISPR/Cas technology;Cryopreservation;cyclophilin D;cytochrome c;Cytomegalovirus;Detection;Development;Dideoxy Chain Termination DNA Sequencing;differential expression;disease model;DNA Damage;Dose;Doxorubicin;Drug Prescriptions;Enzymes;European;Event;Exons;experience;experimental study;Exposure to;Family;Genes;Genetic;Genetic study;genetic variant;Genome;genome editing;genome wide association study;genomic tools;Genomics;Genotype;glutathione peroxidase;Heart failure;Heart Transplantation;High Prevalence;Homeostasis;Human;human disease;human induced pluripotent stem cells;Image;In Vitro;Individual;induced pluripotent stem cell derived cardiomyocytes;inhibitor;innovation;insight;interest;Kinetics;Knock-out;knockout gene;Knowledge;leukemia;logarithm;Lymphoma;Malignant Childhood Neoplasm;manufacturing run;Manuscripts;Measurement;Mediating;Medicine;member;Metabolism;meter;Methodology;Mitochondria;mitochondrial membrane;mitochondrial permeability transition pore;mixed lineage kinase 3;Modality;Molecular;monolayer;morphogens;Necrosis;Neomycin;Neon;novel;Online Systems;Outer Mitochondrial Membrane;overexpression;Pathway interactions;patient response;Patients;pediatric patients;Performance;Pharmaceutical Preparations;Phenotype;Phosphotransferases;Plasmids;Poly(ADP-ribose) Polymerases;Predisposition;prevent;Procedures;Process;Production;promoter;Protein Kinase Interaction;Publishing;Puromycin;Quantitative Trait Loci;racial disparity;Radiation therapy;Reactive Oxygen Species;Receptor-Interacting Protein;Regimen;Research;response;Risk Factors;risk prediction model;Role;Route;Sarcoma;Science;sex;Signal Transduction;Single Nucleotide Polymorphism;Stains;Staurosporine;Survivors;System;Techniques;Time;tool;Transfection;Treatment Efficacy;Tumor Necrosis Factor Receptor;Update;user-friendly;Validation;Variant;Work

PROJECT_TITLE: Predicting and Preventing Chemotherapy-InducedCardiotoxicity in African American Children


ORG_DEPT: BIOCHEMISTRY

PHR: Project Narrative Aneuploidy is very frequent in cancer but its role in tumorigenesis and as a potential target for cancer therapy is poorly understood. Within the scope of the funded parent grant, this application aims at performing computational analyses on existing data on colorectal cancer patients to better define the cancer driver genes located on chromosome 7 and at validating experimentally these predictions. The other main goal of this application is to foster scientific and educational training for Elaine Camacho-Hernandez to promote her future academic career.

PI_NAMEs: DAVOLI, TERESA  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Adopted;Affect;Aneuploid Cells;Aneuploidy;Biological Markers;Cancer Patient;career;Cell Death;Cell model;cell type;Cells;Cellular Stress;Chromosome 7;Chromosomes;Clinical Research;colon cancer patients;Colorectal Neoplasms;Computer Analysis;Data;Diploid Cells;Disease;Engineering;experimental study;Fostering;Foundations;Funding;Future;Genes;Genetic Transcription;Genomics;Goals;Human;improved;In Vitro;in vivo;Knowledge;Malignant Neoplasms;mouse model;neoplastic cell;Normal tissue morphology;Outcome;parent grant;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Phenotype;Phosphoproteins;Proliferating;Proteins;Regulation;Role;Sampling;Solid Neoplasm;synthetic lethal interaction;System;targeted cancer therapy;therapeutic target;therapy resistant;Training and Education;Translations;tumor;tumor progression;tumorigenesis

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ORG_CITY: DAVIS

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative There is an urgent need to identify modifiable structural drivers of youth community violence that can be leveraged for long-term primary prevention efforts. By examining the role that housing policies play in community violence, findings from this project will provide actionable knowledge about the structural determinants of youth community violence and related disparities, including insight into the mechanisms underlying these relationships. This research will also provide policy-relevant findings to local and state governments interested in far-reaching, sustainable reductions in violence through a strategic approach to housing policy.

PI_NAMEs: KAGAWA, ROSE  (contact);PEAR, VERONICA A.

PROJECT_TITLE: Exploring the Effectiveness of Housing Policy as a Structural Intervention to Reduce Community Violence: An Evaluation of Choice Neighborhoods and Source of Income Anti-Discrimination Laws

STUDY_SECTION_NAME: Special Emphasis Panel[ZCE1 TQD (30)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Multiple Sclerosis;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: PROJECT NARRATIVE Falls are a major public health concern in persons with Multiple Sclerosis (MS), resulting in expensive medical costs, serious injuries, reduced quality of life, and loss of independence. Fear of falling (FOF) is both a cause and consequence of falls that traps individuals in a vicious cycle of reduced balance confidence, avoidance behavior, physical deconditioning, increased fall risk, and subsequent greater FOF. This study aims to comprehensively examine neural, motor, cognitive, and psychological contributions to FOF and determine their long-term impact on future falls and physical activity, with an overarching goal of identifying targets for rehabilitation strategies to break the vicious FOF cycle and ultimately reduce falls in the MS community.

PI_NAMEs: TAKLA, TAYLOR  (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Address;Advisory Committees;Affect;Amygdaloid structure;Anxiety;associated symptom;avoidance behavior;behavior measurement;Behavioral;Brain region;career;Cerebellum;Clinical;Clinical assessments;clinical translation;Cognition;Cognitive;cognitive function;Communities;Complex;contextual factors;Data;deconditioning;Development;Emotional;emotional functioning;Emotions;equilibration disorder;Equilibrium;experience;Fall prevention;fall risk;falls;fear of falling;Fostering;Fright;Future;Gait;Goals;Health;Hippocampus;Human;Image;Impairment;improved;Incidence;Individual;Injury;innovation;interest;Intervention;Laboratories;Link;Magnetic Resonance Imaging;Measures;Medical Care Costs;Mental Depression;Mentors;Mission;Monitor;Moods;Motor;motor symptom;MRI Scans;multimodal neuroimaging;Multiple Sclerosis;multiple sclerosis patient;Nature;neglect;neural;neural circuit;neural correlate;Neurobehavioral Manifestations;neuroimaging;neurological rehabilitation;Neurotic Disorders;novel;older adult;Outcome;Participant;Performance;Physical activity;Population;Positioning Attribute;Postdoctoral Fellow;Process;prospective;psychologic;psychological distress;Psychological Factors;psychological symptom;Psychopathology;Public Health;Qualifying;Quality of life;Recording of previous events;rehabilitation strategy;Relapsing-Remitting Multiple Sclerosis;Reporting;Research;Research Personnel;Research Training;response;Scientific Advances and Accomplishments;skills training;Social isolation;Statistical Data Interpretation;statistics;successful intervention;Testing;Time;Training;training project;United States National Institutes of Health;Visit;Well in self;Work

PROJECT_TITLE: Investigating Fear of Falling in Multiple Sclerosis: An Interplay of Neural, Motor, Cognitive, and Psychological Factors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


NIH_SPENDING_CATS: Bioengineering;Cancer;Nanotechnology;Wound Healing and Care

ORG_CITY: KENT

ORG_NAME: KENT STATE UNIVERSITY

PHR: Project Narrative This project will test that the mechanical stability between RGD, a tripeptide, and integrin is correlated with cell migration. The project will also evaluate the effect of cell membrane receptors, such as Epidermal Growth Factor Receptor (EGFR), on cell migration. The knowledge obtained will help to fight various diseases associated with abnormal cell migrations.

PI_NAMEs: MAO, HANBIN  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: 3-Dimensional;Abnormal Cell;Acidity;Acids;Actins;Address;Affinity;alkalinity;Autoimmune Diseases;Binding;Biological Process;biomaterial compatibility;Blood Vessels;cancer cell;CD36 gene;Cell Communication;Cell membrane;cell motility;Cell Physiology;Cell surface;Cells;Cellular Morphology;Chemicals;Cholesterol;Competitive Binding;Complementary DNA;Complex;Cues;Cytoskeletal Proteins;density;design;Digestion;Disease;Distal;DNA;Dyes;Elements;Embryonic Development;Ensure;Enzymes;Epidermal Growth Factor Receptor;Equilibrium;ERBB2 gene;experience;extracellular;Extracellular Matrix;Extracellular Protein;fabrication;Fiber;fighting;Fluorescence Resonance Energy Transfer;fluorophore;Focal Adhesions;Genetic;Growth;healing;Hela Cells;Human;Image;Immune response;In Situ;innovation;instrument;Integrin Binding;Integrins;invention;knock-down;Knowledge;laser tweezer;Lateral;Length;Ligands;Lipids;Macrophage;magnetic beads;Magnetism;Measures;mechanical properties;Mechanics;mechanotransduction;Membrane;Membrane Microdomains;Methods;migration;Monitor;Morphology;nano-objects;nanoassembly;nanodevice;nanoscale;Nanostructures;Neoplasm Metastasis;Oligonucleotides;optic tweezer;overexpression;Pathway interactions;Penetration;Peptides;Phosphorylation;Photons;photostimulus;Process;Property;receptor;Reporting;restoration;side effect;Signal Pathway;Signal Transduction;single molecule;Single-Stranded DNA;skin wound;Skin wound healing;Specificity;Structure;Supplementation;Surface;Techniques;Tertiary Protein Structure;Testing;three dimensional structure;Time;tool;tumor;Variant;Western Blotting;wound healing

PROJECT_TITLE: Supplemental Request for Mechanical Modulation of Cell Migrations by DNA Nanoassemblies

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: ANN ARBOR

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Cocaine use disorder is one of the most challenging disorders for society to address due to its rapid progression and lack of approved treatments/therapies. Identifying the neurochemical changes arising from this chronic disorder will be beneficial for providing early medical intervention for those affected; however, current technology is not capable of discovering these chemical alterations. In this project, we will develop new instrumentation and data analysis techniques that enhance our ability to monitor neurochemicals in the living brain and address questions relating to the underlying cause of cocaine use disorder within an animal model for addiction.

PI_NAMEs: CAIN, CAITLIN  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: addiction;Address;advanced analytics;Affect;Analytical Chemistry;Animal Model;Award;Behavior;behavioral phenotyping;Blood capillaries;Brain;brain based;Brain Chemistry;Brain region;brain volume;Breeding;capillary liquid chromatography;career;chemical standard;Chemicals;Chronic Disease;Classification;clinically relevant;Cocaine;Cocaine Dependence;cocaine self-administration;cocaine use;Cocaine use disorder;Communication;Complex;Computational algorithm;Computing Methodologies;Data;Data Analyses;Databases;detection sensitivity;Development;Development Plans;differential expression;Disease;Dopamine;drug seeking behavior;Educational process of instructing;Environment;Equilibrium;Esthesia;Extracellular Space;Fellowship;Female;Foundations;Future;Grant;Hour;improved;in vivo;Individual;instrumentation;Intake;Intervention;Knowledge;Libraries;Liquid Chromatography;liquid chromatography mass spectrometry;Liquid substance;Machine Learning;machine learning model;male;Mass Chromatography;Mass Spectrum Analysis;Measures;Medical;Mentorship;metabolome;metabolomics;Methods;Michigan;Microdialysis;miniaturize;Modeling;Molecular;Monitor;Motivation;neurochemistry;Neurons;Neurosciences;neurotransmitter release;new therapeutic target;novel;novel strategies;Nucleus Accumbens;particle;Pathway interactions;pedagogy;Pharmacotherapy;Phase;Phenotype;Preparation;professor;Psychosocial Stress;psychostimulant;Rattus;Research;Research Design;Resolution;Resources;response;Rewards;Sampling;Self Administration;sex;Signal Transduction;skills;Societies;stimulant use;Structure;Technical Expertise;Techniques;Technology;tenure track;Testing;Training;two-dimensional;ultra high resolution;Universities;Work

PROJECT_TITLE: Enabling Discovery-Based Brain Metabolomics with Ultra-High Resolution Liquid Chromatography and Machine Learning

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_DEPT: NEUROSCIENCES

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Drugs of abuse drive addiction by inducing long lasting changes in the function of brain regions that underlie motivated behaviors. Here we will use novel molecular genetics technologies to test the role of chromatin regulation at synaptic plasticity genes in a mouse model of cocaine craving. These studies will deepen mechanistic understanding of the neuronal plasticity that leads to addiction.

PI_NAMEs: FOWLER, CHRISTIE D;WEST, ANNE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: 3-Dimensional;Abstinence;addiction;Address;Architecture;Behavior;Behavior assessment;Behavioral;Behavioral Genetics;behavioral pharmacology;behavioral study;Biochemical;Biology;Brain;Brain region;Brain-Derived Neurotrophic Factor;Cell Nucleus;cell type;Cells;Cessation of life;Chromatin;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Cocaine;cocaine craving;Cocaine Dependence;cocaine exposure;cocaine seeking;cocaine self-administration;cocaine use;craving;Cues;Data;Development;dopaminergic neuron;drug maintenance;drug of abuse;drug relapse;drug seeking behavior;Drug usage;Enhancers;Epigenetic Process;epigenome;Etiology;Exposure to;Female;Gene Expression;Gene Expression Regulation;gene repression;Genes;genetic approach;genetic technology;Genetic Transcription;Genome;Genome engineering;genome-wide;Genomics;Heterogeneity;human model;in vivo;Incubated;Individual;innovation;Intravenous;Knowledge;Link;Maintenance;male;Mediating;Memory;Methods;Molecular Genetics;Morbidity - disease rate;mortality;motivated behavior;mouse model;Mouse Strains;Mus;Nature;neural;Neuronal Plasticity;Neurons;novel;novel strategies;Pattern;Pharmaceutical Preparations;Physiological;Play;Population;Procedures;promoter;Protocols documentation;psychostimulant;Regulation;Regulatory Element;Relapse;Rewards;RNA;Rodent Model;Role;social relationships;stimulant misuse;Synaptic plasticity;Testing;Time;transcription factor;Transcriptional Regulation;Transgenic Mice;Ventral Tegmental Area;Viral;Vulnerable Populations

PROJECT_TITLE: Chromatin regulation of BDNF in cocaine craving

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Narrative The Common Fund Visualization Hub project aims to develop a transformative cloud-based integrative visualization platform to enable interactive exploration of multimodal biomedical data, using large omics and imaging datasets sourced from CFDE DCCs and external consortia. The Hub's innovative architecture, focusing on user-driven visualization construction and storytelling, promises to accelerate discovery and improve the accuracy of predictive models in genomic research. The Hub will be used to evaluate models predicting the target genes of candidate cis regulatory elements, which is of great importance to dissecting the biological function of noncoding genetic variants in human traits and disease.

PI_NAMEs: GEHLENBORG, NILS  (contact);WENG, ZHIPING

PROGRAM_OFFICER_NAME: PAPANICOLAOU, GEORGE

PROJECT_TERMS: Acceleration;Address;Adoption;Architecture;bioimaging;Biological;Biological Process;Candidate Disease Gene;Cell Aging;Cells;Chromatin;chromosome conformation capture;cloud based;Collaborations;Communication;Communities;community empowerment;Controlled Vocabulary;Custom;Data;Data Analyses;data communication;Data Coordinating Center;data ecosystem;data exploration;data hub;Data Management Resources;data portal;data resource;Data Set;Data Sources;data visualization;design;Development;Disease;Distal;Ecosystem;effectiveness evaluation;Encyclopedia of DNA Elements;Ensure;epigenomics;Evaluation;evidence base;experimental study;Feedback;flexibility;Funding;Gene Expression Regulation;General Population;Generations;Genes;Genetic;genetic variant;Genome;Genome Mappings;genome sciences;genomic data;genomic locus;Genomics;Genotype-Tissue Expression Project;Goals;Gold;Hi-C;Human;Human BioMolecular Atlas Program;Image;improved;Ingestion;innovation;insight;interactive visualization;interest;interoperability;Investments;Link;Linkage Disequilibrium;Liquid substance;machine learning model;machine learning prediction;Maps;member;Metadata;Methodology;Methods;model development;Modeling;Molecular;Morphologic artifacts;Motivation;multimodal data;multimodality;Output;predictive modeling;Privatization;Process;Quantitative Trait Loci;Regulatory Element;repository;Research;Research Personnel;software infrastructure;Source;Structure;success;Support System;System;tool;trait;transcriptomics;Untranslated RNA;Validation;Variant;Visual;Visualization;Visualization software

PROJECT_TITLE: Community Data Hub for Integrative Visualization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-E (56)]