ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Immunotherapy;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: PITTSBURGH

ORG_NAME: ALLEGHENY-SINGER RESEARCH INSTITUTE

PHR: Project Narrative Chimeric antigen receptor (CAR)-based T-cell transfer therapy has achieved tremendous clinical success in treating refractory and relapse B cell lymphoblastic cancers. However, the treatment can also lead to over production of inflammatory molecules in some patients, which could be life threatening without clinical intervention. In this exploratory R21 project, we will develop a novel animal model to further understand these CAR-T treatment-associated toxicities. The work will unravel novel factors and cell types responsible for the progression of these side effects, and help to develop novel therapies to mitigate and/or prevent them.

PI_NAMEs: FAN, YONG  (contact)

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Adrenal Cortex Hormones;Allogenic;anakinra;Animal Model;antagonist;anti-tumor immune response;antitumor effect;Autoimmune Diseases;Autologous;B lymphoid malignancy;B-Cell Leukemia;B-Lymphocytes;Blocking Antibodies;Blood Cells;Body Temperature;Body Weight;cancer cell;Cancer Model;cancer therapy;CAR T cell therapy;CD19 gene;CD28 gene;CD3 Antigens;Cell Compartmentation;cell mediated immune response;cell type;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Clinic;Clinical;Clinical Protocols;cohort;Complex;cytokine;cytokine release syndrome;Development;Disease;drug discovery;engineered T cells;Engraftment;Ethics;Failure;Fever;Functional disorder;Generations;Growth;Harvest;Hematopoietic;Hematopoietic stem cells;Histopathology;Human;human fetal thymus;humanized mouse;Hypotension;IL1R1 gene;Immune;Immune response;Immune system;Immunodeficient Mouse;Immunoglobulin Class Switching;Immunotherapeutic agent;Immunotherapy;Incubated;induced pluripotent stem cell;Inflammatory;Inflammatory Response;Interleukin-1;Interleukin-6;Intervention;Left;Life;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Mediator;Melanoma Tumor;Methods;Modeling;Molecular;Monitor;Monoclonal Antibodies;monocyte;mouse model;multiplex assay;Muromonab-CD3;Mus;neurotoxicity;novel;novel therapeutics;Organ;Organoids;Outcome;particle;Pathway interactions;Patients;Physiology;Pre-Clinical Model;preclinical study;Precursor B-Lymphoblast;prevent;primary lymphoid organ;Production;Proteome;Proteomics;reconstitution;Refractory;Relapse;Research;Role;Serum;side effect;single-cell RNA sequencing;Solid Neoplasm;Source;Splenocyte;Stimulus;success;T cell therapy;T-Cell Development;T-Cell Receptor;T-cell receptor repertoire;T-Cell Receptor Therapy;T-Lymphocyte;Thymus Gland;Tissue Engineering;Tissues;tocilizumab;Toxic effect;transcriptome;Transplantation;Transplantation Tolerance;Treatment-related toxicity;tumor;Tumor Antigens;Tumor Burden;United States Food and Drug Administration;Work

PROJECT_TITLE: Novel hematopoietic humanized mouse model to study CAR-T therapy-associated cytokine release syndrome

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: DURHAM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_FIPS: US

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: OVERALL: PROJECT NARRATIVE Urinary stone disease (USD) is a benign but severely painful genitourinary disease that is the second most costly urologic condition in the US with a healthcare expenditure over $2 billion per year. The surgical treatment of USD in patients is carried out primarily by laser lithotripsy (LL) via ureteroscopy, including pop-dusting to reduce renal calculi with a size up to 1.5 cm to dust in situ in the kidney without the need for fragment extraction. The research project proposed in this Duke University FORWARD Urology Center (P20) application aims to explore a unique and novel strategy of using nanoparticles fine-tuned to improve Holium:YAG or Thulium fiber laser absorption in the near infrared range to improve the treatment efficiency, while concomitantly reducing the risk of renal tissue injury and procedure time during clinical LL.

PI_NAMEs: PAYNE, CHRISTINE K;ZHONG, PEI  (contact)

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: Ablation;absorption;American;Applications Grants;Benign;Biomechanics;Biophotonics;career development;cell injury;Clinical;Collaborations;Communities;Computer Models;cost;Data;Data Collection;Data Scientist;Development Plans;Disease;Doctor of Philosophy;Dust;Engineering;Enhancement Technology;experience;Faculty;Fiber;Fostering;Foundations;Frequencies;Future;Goals;Health Expenditures;Holmium;Hydrogels;improved;In Situ;In Vitro;in vivo;Injury to Kidney;innovation;Interdisciplinary Study;Irrigation;Journals;Kidney;Kidney Calculi;Knowledge;Laser Lithotripsy;Lasers;Lithotripsy;Mentored Clinical Scientist Development Program;Modeling;multidisciplinary;Names;nanomaterials;nanoparticle;Nanotechnology;National Institute of Diabetes and Digestive and Kidney Diseases;novel strategies;operation;Operative Surgical Procedures;Optics;optimal treatments;Pain;Paper;Patients;Play;porcine model;Procedures;Productivity;programs;Published Comment;recruit;Renal Tissue;Research;Research Activity;Research Personnel;Research Project Grants;Resources;Risk;Risk Reduction;Role;Safety;Saline;Shock;Societies;Solid;success;synergism;Technology;Temperature;theories;Thulium;Time;tissue injury;Toxic effect;treatment choice;Universities;Ureteroscopy;Urinary Calculi;Urogenital Diseases;urologic;Urology

PROJECT_TITLE: Enhancing Laser Lithotripsy via Nanoparticle Fine-Tuned NIR absorption


PI_NAMEs: ZHONG, PEI  (contact)

PROJECT_TERMS: Ablation;absorption;Address;Benign;career;career development;Clinical;Clinical Research;Clinical Treatment;Collaborations;Communities;Consultations;cost;Data Scientist;data sharing;Development;Development Plans;Disease;Dust;Educational workshop;experience;Fiber;Frequencies;Future;Goals;Health Expenditures;Holmium;improved;In Situ;Injury to Kidney;innovation;Institution;Knowledge;Laser Lithotripsy;Lasers;Lead;Liquid substance;member;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Methods;multidisciplinary;nanomaterials;nanoparticle;Nanotechnology;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;novel strategies;operation;Outcome;Patients;Play;Positioning Attribute;Prevalence;Procedures;Productivity;Program Development;programs;Public Health;Research;Research Infrastructure;Research Institute;Research Personnel;Research Project Grants;Research Support;Resources;Risk;Role;Sampling;Science;Structure;Talents;Technology;theories;Thulium;Time;tissue injury;Tissues;tool;Toxic effect;Training;treatment choice;Treatment outcome;Universities;Ureteroscopy;Urinary Calculi;urologic;Urology;Work

PROJECT_TITLE: Administrative Core


PI_NAMEs: HSU, PO-CHUN  (contact)

PROJECT_TERMS: absorption;Adverse event;Affect;American;Artificial Kidney;Behavior;Benign;calyx structure;cell injury;Cells;Clinical;Collaborations;Communities;Dangerousness;Data Collection;Data Scientist;Dependence;Disease;Doctor of Philosophy;Dose;Dust;Effectiveness;Elements;Engineering;Enhancement Technology;experience;Family suidae;Fiber;Frequencies;Future;Goals;Health Expenditures;heat injury;Holmium;Hydrogels;improved;In Situ;In Vitro;in vivo;Injury to Kidney;Kidney;Kidney Calculi;Knowledge;Laser Lithotripsy;Lasers;Liquid substance;Mentored Clinical Scientist Development Program;metallicity;Modeling;nanoengineering;nanomaterials;nanoparticle;nanophotonic;nanopolymer;Nanotechnology;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;Optics;Pain;photonics;Physiologic pulse;Pilot Projects;Play;Polymers;porcine model;Positioning Attribute;power consumption;Procedures;Process;programs;Property;Publishing;renal damage;Reporting;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Risk;Risk Reduction;Role;Safety;safety assessment;Saline;Science;Stream;Surface;synergism;Techniques;Temperature;theories;Thulium;Time;Tissues;Toxic effect;treatment choice;Universities;Urinary Calculi;Urinary tract;Urogenital Diseases;urologic;Urology

PROJECT_TITLE: Research Project


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: ORLANDO

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

ORG_STATE: FL

PHR: Project Narrative  Vaccines against respiratory viruses can be improved by targeting the generation of memory CD4 T cells that reside long-term in the lung, but signals promoting the optimal generation of this memory subset are unclear. This proposal will delineate how type I interferon, a signature anti-viral cytokine produced in the lung, acts to promote establishment of lung-resident memory CD4 T cells during infection and vaccination. Our goal is to develop strategies to harness type I interferon to promote lung-resident memory CD4 T cells and to improve the ability of such memory cells to respond to infection.

PI_NAMEs: MCKINSTRY, KARL KAI (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Acute;Address;Adopted;Animal Model;Antibodies;Antigens;CD4 Positive T Lymphocytes;Cells;Cellular Immunity;Clinical Research;conditioning;cytokine;Data;Disease Outcome;Dominant-Negative Mutation;Effectiveness;effector T cell;Elements;Environment;Epitopes;fitness;functional outcomes;Gene Expression;Generations;Genetic Transcription;global health;Goals;Immune;Immune response;Immunity;improved;improved outcome;Infection;Inflammatory;inflammatory milieu;inflammatory modulation;Influenza;Influenza A virus;insight;Interferon Type I;Interferons;Kinetics;Lead;Lung;Maintenance;Mediating;Memory;memory CD4 T lymphocyte;memory recall;Modeling;Molecular Target;mouse model;Mus;neutralizing antibody;Outcome;pandemic disease;pathogen;Pathogenicity;Pathway interactions;Phenotype;Productivity;programs;Repression;Research;respiratory pathogen;respiratory virus;response;Role;seasonal influenza;Seasons;Shapes;Signal Transduction;Site;STAT protein;STAT1 gene;STAT4 gene;Structure of parenchyma of lung;T cell response;T memory cell;T-bet protein;T-Cell Activation;T-Lymphocyte Subsets;Testing;Therapeutic;tissue resident memory T cell;Tissues;Transcriptional Activation;translational model;treatment optimization;universal influenza vaccine;Vaccination;vaccination strategy;vaccine development;vaccine efficacy;vaccine-induced immunity;Vaccines;Viral;Virus;Virus Diseases

PROJECT_TITLE: Harnessing type I interferon to promote lung-resident memory CD4 T cell immunity against influenza

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-N(90)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Cannabinoid Research;Genetics;Mental Health;Neurosciences;Therapeutic Cannabinoid Research

ORG_CITY: PROVIDENCE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: This project will elucidate basic mechanisms of neuronal communication, as well as novel mechanisms of the effects of cannabinoids on neuronal communication. Given the widespread use of cannabinoids for recreational and therapeutic purposes, understanding the mechanistic basis of their effects of these substances in the central nervous system is urgently needed.

PI_NAMEs: ANDRADE, ARTURO  (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Absence of pain sensation;Action Potentials;Acute;Agonist;Alternative Splicing;Amino Acids;Anxiety;Anxiety Disorders;Area;Axon;Biochemical;Biochemistry;Biological Assay;biophysical properties;Brain;Calcium;Calcium Channel;cannabinoid treatment;Cannabinoids;Cells;Central Nervous System;Cholecystokinin;Clinical;CNR1 gene;Cognition;Communication;Coupled;Coupling;Development;dimer;Dose;drug sensitivity;Electrophysiology (science);Emotional;Excitatory Synapse;Exhibits;Exons;gamma-Aminobutyric Acid;Genes;Glutamates;Goals;hippocampal pyramidal neuron;Hippocampus;Impaired cognition;Impairment;improved;Inhibitory Synapse;innovation;insight;Interneurons;Knowledge;Label;Learning;Memory;Molecular;Morphine;mouse model;Neurons;neurotransmission;new therapeutic target;novel;novel therapeutics;Opioid Receptor;Pharmacology;Physiology;presynaptic;prevent;Probability;Proteins;recombinase;Recreation;recruit;Regulation;response;RNA Splicing;Role;selective expression;Shapes;Signal Transduction;Site;Slice;SNAP receptor;Synapses;syntaxin 1A;Testing;Therapeutic;Variant;Work

PROJECT_TITLE: CaV2.2 splice variants in the hippocampus: function and pharmacology

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


NIH_SPENDING_CATS: Osteoporosis

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project narrative This proposal brings a first of its kind computational pipeline and experimental approaches for identifying specific small molecules that can allosterically modulate the activity of parathyroid hormone (PTH) receptor (PTHR), a medically important G protein-coupled receptor (GPCR) for the treatment of bone and mineral diseases such as osteoporosis, hyperparathyroidism, and hypercalcemia of malignancy.

PI_NAMEs: BAHAR, IVET ;VILARDAGA, JEAN-PIERRE  (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: 25-hydroxyvitamin D;Address;Affect;Affinity;Allosteric Site;Binding;Biological Assay;Blood;bone;Bone Diseases;Bone remodeling;bone turnover;Calcium;Cell Physiology;Cells;Communication;Complex;computational pipelines;computer studies;conformer;Coupled;Coupling;Cryoelectron Microscopy;Cyclic AMP;CYP27B1 gene;Data;Databases;Defect;design;Disease;Elasticity;Endocrine System Diseases;enzyme biosynthesis;experimental study;extracellular;Feedback;Fracture;Future;G alpha q Protein;G-Protein-Coupled Receptors;Genetic Polymorphism;Goals;GTP-Binding Proteins;Homeostasis;hormonal signals;human disease;Hyperactivity;Hypercalcemia;Hypercalcemia of Malignancy;Hyperparathyroidism;Hypocalcemia;improved;in silico;Individual;inorganic phosphate;Ions;Libraries;Ligand Binding;Ligands;Location;Mechanics;Mediating;Medical;Methods;mineralization;Minerals;Modeling;Modification;Molecular Conformation;molecular dynamics;multidisciplinary;network models;novel;Organic Chemistry;Osteoblasts;Osteoporosis;Parathyroid Hormone Receptor;parathyroid hormone-related protein;particle;Pathology;peptide hormone;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology Study;pharmacophore;pilot test;Polypeptide Hormones;programs;Property;protein activation;protein complex;PTH gene;Public Health;receptor;receptor function;receptor internalization;Receptor Signaling;Recombinants;Recycling;Research;Resolution;response;screening;Second Messenger Systems;Signal Pathway;Signal Transduction;simulation;Site;small molecule;Specificity;structural biology;Structure;Testing;Therapeutic;Time;trafficking;validation studies;virtual model;virtual screening;Vitamin D

PROJECT_TITLE: Structure and function of PTH class B GPCR

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homelessness;Mental Health;Social Determinants of Health

ORG_CITY: CHESTNUT HILL

ORG_NAME: BOSTON COLLEGE

ORG_STATE: MA

PHR: PROJECT NARRATIVE The economic shock of the COVID-19 pandemic threatened a wave of evictions, increases in housing instability and food insufficiency, and subsequently health and mental health challenges arising from these stresses. The federal government enacted the Emergency Rental Assistance Program (ERAP) to assist vulnerable renters, with wide state and local discretion and variability in program implementation. This study will (1) create a public use dataset documenting the nature and timing of ERAP implementation policy choices, and (2) evaluate effects of ERAP policies on risk of eviction, experiences of material hardship, and mental health using quasi-experimental methods.

PI_NAMEs: FUSARO, VINCENT  (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Address;Adoption;Anxiety;Area;Attenuated;Binomial Model;Censuses;Color;Communities;cost;County Government;COVID-19;COVID-19 pandemic;Data;Data Set;Data Sources;Databases;design;Development;Dimensions;Disadvantaged;Distress;Documentation;Economics;Effectiveness;Emergency Situation;Employment;Evaluation;experience;Federal Government;Female;field survey;Financial Hardship;Financial Support;flexibility;Food;food insecurity;Fright;Funding;Future;geographic difference;Geography;Goals;Guidelines;Health;health disparity;Homelessness;Household;Household Heads;Housing;housing instability;Income;Inequity;innovation;Interdisciplinary Study;Internet;Link;Logistic Regressions;Low income;marginalization;Measures;Mental Depression;Mental Health;Methods;Modeling;Municipal Government;Municipalities;Nature;Neighborhoods;Outcome;Outcome Study;pandemic disease;payment;Personal Satisfaction;Physiologic pulse;Policies;Policy Analysis;programs;Public Health;public health emergency;Quasi-experiment;Research;Resources;response;Risk;Shock;social health determinants;Social outcome;Source;State Government;Stress;Surveys;System;Techniques;Time;trend;Unemployment;user-friendly;Variant;Work

PROJECT_TITLE: Evaluating Rental Relief During the COVID-19 Pandemic

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Data Science;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE Antiretroviral therapy (ART) for people with Human Immunodeficiency Virus (HIV) can successfully bring down viral load, minimize infectiousness, and improve quality of life. Despite availability of ART subsidization in the US, several states including Florida experience high prevalence of virological failures, HIV comorbidity, with enormous racial and social disparity in ART outcomes. Fusion of causal inference and artificial intelligence methods, in conjunction with real-world multilevel data (e.g., electronic health records, social determinants of health) and expert-designed interventions, is key to develop models that can be actioned to improve ART outcomes and reduce disparity.

PI_NAMEs: BIAN, JIANG ;PROSPERI, MATTIA  (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: Address;Adherence;Affect;African American population;Algorithms;antiretroviral therapy;Area;Artificial Intelligence;artificial intelligence method;artificial intelligence model;Behavioral;Black race;Calibration;care outcomes;Caring;citizen science;Clinical;Clinical Research;cohort;Cohort Studies;comorbidity;Complex;Coupled;Data;data integration;Data Sources;Databases;deep learning;deprivation;Disparity;disparity reduction;Electronic Health Record;electronic structure;Epidemiology;experience;Expert Systems;Failure;Florida;Focus Groups;Goals;Health;Health Benefit;health determinants;health equity;Health Personnel;Health Services Accessibility;High Prevalence;high risk;HIV;immune reconstitution;Immunologics;implementation science;improved;Incidence;Individual;Infrastructure;instrument;Intervention;intervention effect;Interview;Link;Measurement;meetings;Methodology;Methods;Minority;Modeling;multidisciplinary;Natural Language Processing;novel;Outcome;outcome disparities;Patients;Persons;Population;pre-exposure prophylaxis;Precision Health;privacy preservation;programs;prospective;Protocols documentation;Provider;Public Health;public health intervention;public health relevance;Quality of life;Race;racial disparity;Recording of previous events;Resistance;response;Risk;Risk Reduction;Sampling;social;social disparities;social health determinants;social stigma;sociodemographic factors;Standardization;statistics;Structure;Surveys;Testing;therapy adherence;therapy design;therapy outcome;uptake;usability;Viral Load result;Virus Diseases;Work

PROJECT_TITLE: Artificial Intelligence and Counterfactually Actionable Responses to End HIV (AI-CARE-HIV)

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetic Testing;Genetics;Mental Health;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: Narragansett

ORG_NAME: PRO-CHANGE BEHAVIOR SYSTEMS, INC.

PHR: 8. Project Narrative For the estimated one out of every 300 Americans who have a Hereditary Cancer Syndrome but have not yet been diagnosed with cancer (Previvor), adversity often comes disguised as a multitude of cancer screenings a year and the uncertainty of the health of family members. The proposed research will develop and evaluate a prototype of PREcharge, an interactive program designed to increase resilience among Previvors by administering brief assessments and using multivariate algorithms and proven approaches to behavior change tailoring to provide timely, individually tailored text messages to promote a positive mindset, strong social connections, and a deep sense of meaning and purpose while also proactively addressing scanxiety through online tools. This program has the potential to improve the psychological health of a growing population of individuals navigating the uncertainty and emotional toll of Hereditary Cancer Syndromes.

PI_NAMEs: EVERS, KERRY  (contact)

PROGRAM_OFFICER_NAME: CONNORS, BRITTANY SEAN

PROJECT_TERMS: Address;Adherence;Affect;Age;Algorithms;American;Anxiety;Area;Back;Behavior;behavior change;cancer diagnosis;Cancer Etiology;cancer risk;cancer type;Caring;Charge;Child;Communication;Complex;coping;cost effective;Data;design;Development;Diagnosis;digital solutions;DNA Sequence Alteration;Effectiveness;Emotional;epidemiological model;evidence base;experience;Face;Family;Family Caregiver;Family health status;Family member;Fatigue;Feedback;Foundations;Future;Gene Mutation;General Population;Genes;Genetic Predisposition to Disease;genetic testing;Germ-Line Mutation;Goals;Health;Health Personnel;Health Promotion;Hearing;Hereditary Malignant Neoplasm;Hereditary Neoplastic Syndromes;improved;Individual;Inherited;innovation;Intervention;intervention program;Knowledge;Learning;Life;lifetime risk;Malignant Neoplasms;Meaning and purpose;Measures;Mental Depression;Mental Health;Metaphor;Mutation;next generation;Operative Surgical Procedures;Organ;Outcome;Parents;Participant;Persons;Phase;pilot test;Population;Process;Program Acceptability;programs;promote resilience;prophylactic;protective behavior;prototype;provider communication;Public Health;Quality of life;Recommendation;Recording of previous events;recruit;Research;resilience;resilience scale;Resistance;Resources;Risk;Risk Reduction;Scanning;Science;Screening for cancer;Screening Result;skills;social;Specific qualifier value;Stress;stressor;tailored text messaging;Technology;Testing;Text Messaging;Thinking;Time;tool;Uncertainty

PROJECT_TITLE: Previvors Recharge: A Resilience Program for Cancer Previvors


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Hematology;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Precision Medicine;Rare Diseases;Sepsis

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE We have assembled an investigator team from three institutions that bring deep and relevant scientific experience and a track record of robust clinical enrollment to conduct the consortium-wide MUltidimenSional phenotyping In Critical care (MUSIC) and the HME for Acute Respiratory failure MultidimensiONal phenotYping (HARMONY) Studies as pathways to precision medicine at the bedside.

PI_NAMEs: WARE, LORRAINE B (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Acute respiratory failure;Address;Alveolar;Biological;Biological Markers;Biology;Caring;Circulation;Classification;Clinical;clinical center;Clinical Research;Clinical Trials;Cognitive;cohort;Cohort Studies;Collection;Consensus;Critical Care;Critical Illness;Data;design;Diagnosis;Dimensions;Distal;Endothelium;Enrollment;Environmental Exposure;Environmental Risk Factor;Epithelium;Etiology;experience;Functional disorder;Goals;Heterogeneity;Hospitals;Image;individual patient;Infection;Inflammatory;Infrastructure;Injury;insight;Institution;Integration Host Factors;Intervention;Intubation;Knowledge;Liquid substance;Longterm Follow-up;Lung;lung imaging;machine learning model;Measures;Mechanical ventilation;Methods;Modeling;multidisciplinary;National Heart, Lung, and Blood Institute;novel;novel strategies;observational cohort study;Observational Study;Organ;Outcome;participant enrollment;Pathway interactions;Patient observation;Patients;personalized medicine;pharmacologic;Phase;Phenotype;Plasma;Play;Pneumonia;Positive-Pressure Respiration;precision medicine;Predisposing Factor;Process;prognostication;Pulmonary function tests;Recovery;Research Personnel;respiratory;Respiratory Failure;Respiratory physiology;response;Resuscitation;Sampling;Sepsis;septic patients;Simvastatin;Site;Socioeconomic Factors;Survivors;Syndrome;targeted treatment;Testing;Therapeutic;Time;tool;Translating;ventilation;Ventilator;Work

PROJECT_TITLE: The MUltidimenSional phenotyping In Critical care (MUSIC) Consortium: A pathway to precision medicine at the bedside


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Clinical Research;Osteoporosis;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative Osteoporosis affects approximately 10 million Americans, while another 34 million are suspected to have low bone mass putting them at risk for developing the disease. The majority of current osteoporosis therapies reduces the number of bone resorbing osteoclasts, and as a result, indirectly reduces new bone formation. Successful completion of this project will provide fundamental insights into the mechanisms that modulate individual osteoclast activities in order to develop novel osteoporosis therapies that reduce bone loss while preserving bone formation.

PI_NAMEs: WEIVODA, MEGAN M (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Adult;Affect;Age;age effect;age related;age related changes;Age-Related Bone Loss;Aging;American;Area;Behavior;Behavioral;bone;Bone Diseases;bone erosion;Bone Formation Stimulation;bone loss;bone mass;bone preservation;bone resorbing activity;Bone Resorption;Calvaria;cathepsin K;Cells;Clinical;Coculture Techniques;Coupled;Coupling;Data;Disease;Embryo;Endopeptidase K;Exhibits;Feedback;Fracture;fracture risk;Giant Cells;Hematopoietic stem cells;Heterogeneity;Human;Impairment;improved;In Vitro;in vivo;Individual;innovation;insight;interest;life span;Link;Mediating;Microscopy;Modeling;mouse model;Mus;Myelogenous;new therapeutic target;novel;novel therapeutics;Osteoblasts;Osteoclasts;Osteogenesis;Osteoporosis;osteoporosis with pathological fracture;osteoprogenitor cell;Peptide Hydrolases;Play;Population;prevent;progenitor;recruit;Reporter;Reporting;Risk;Role;Site;Skeleton;spine bone structure;Technology;Testing;tool;Transforming Growth Factor beta;Transgenic Mice;translation to humans;Transplantation;Wild Type Mouse

PROJECT_TITLE: The impact of age-related changes in osteoclast function on the skeleton

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Infectious Diseases;Lung;Orphan Drug;Pneumonia;Pneumonia and Influenza;Precision Medicine;Rare Diseases;Sepsis

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: NARRATIVE The acute respiratory distress syndrome (ARDS), pneumonia, and sepsis are some of the most common clinical problems encountered in critically ill patients, and each of these syndromes is frequently fatal. This Consortium project is seeking to understand variability within and overlap between these syndromes, so that we can determine how best to design new studies and new therapies for patients with these problems and thereby hopefully improve patient outcomes. In addition, this Consortium will create a database of clinical data and biological samples that can be used by future researchers to study related problems.

PI_NAMEs: CALFEE, CAROLYN  (contact)

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Address;Adult;Area;aspirate;Asthma;Biological;biological heterogeneity;Blood;California;Classification;Clinical;clinical center;Clinical Data;clinical database;clinical heterogeneity;Clinical Research;Clinical Trials;cohort;Collection;Conduct Clinical Trials;Critical Care;Critical Illness;Data;Data Set;design;Development;Diagnosis;Diagnostic;diagnostic criteria;Enrollment;Failure;follow-up;Future;General Hospitals;Goals;Heterogeneity;hormone receptor-positive;improved;improved outcome;Inflammatory;insight;Intervention Trial;Knowledge;Lead;Leadership;Longitudinal cohort study;Malignant Breast Neoplasm;Malignant Neoplasms;Mechanical ventilation;metagenomic sequencing;Metagenomics;Microbe;microbial;microbiome;molecular phenotype;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;novel;novel therapeutics;observational cohort study;Observational Study;Outcome;Outpatients;Participant;pathogen;Pathway interactions;patient population;Patient-Focused Outcomes;Patients;Pharmacotherapy;Phenotype;Plasma Proteins;Pneumonia;Population;Population Heterogeneity;precision medicine;prognostic;prognostic value;prospective;Prospective Studies;protein biomarkers;Recording of previous events;Research Personnel;Resolution;Sampling;San Francisco;Sea;Sepsis;Site;Survivors;Syndrome;Tamoxifen;targeted treatment;Taxonomy;Therapeutic;therapeutic target;Trachea;trait;treatment response;Universities;Work

PROJECT_TITLE: Molecular Phenotyping of ARDS, Pneumonia, and Sepsis using Latent Class Analysis and Metagenomic Sequencing


NIH_SPENDING_CATS: Bioengineering;Cancer;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pain Research;Patient Safety;Skin Cancer;Wound Healing and Care

ORG_CITY: NEW YORK

ORG_NAME: SURGIVANCE, INC.

ORG_STATE: NY

PHR: Narrative Surgery is currently the best option for treating invasive cancers, but successful surgery is constrained by the limits of modern pathology methods, specifically rate-limited by histopathology, a time-consuming process that introduces artifacts that limit accurate interpretation, destroys tissue specimens, and causes pain and increased rate of infections and other surgical complications. SurgiVance is developing the Surgical Pathology System (SPS), a compact, durable, confocal-based product that produces high-resolution, 3D, digital pathology images at a patient’s bedside within seconds. This “laboratory-in-a-box” is designed to replace outdated, slow, and expensive tissue specimen processing and imaging procedures in pathology and enable AI-driven analysis.

PI_NAMEs: GAREAU, DANIEL SUMMER (contact)

PROGRAM_OFFICER_NAME: EVANS, GREGORY

PROJECT_TERMS: 3-Dimensional;analog;Artificial Intelligence;Basal cell carcinoma;Benchmarking;Biopsy;cancer diagnosis;cancer invasiveness;cancer subtypes;cancer surgery;Cancerous;care burden;care costs;Clinical;Collaborations;commercial prototype;Computer software;Consumption;contrast imaging;cost;cost effective;design;Devices;Diagnosis;Diagnostic;digital;digital imaging;digital pathology;disease diagnosis;Engineering;Ensure;Equipment;Evaluation;Excision;Failure;Fluorescence;Freezing;Fresh Tissue;Frozen Sections;Funding;Glass;Goals;Head;healing;Health system;Hematoma;Hemorrhage;Histopathology;Hour;Image;imaging system;Imaging Techniques;improved;Infection;infection rate;Infectious Skin Diseases;Laboratories;Lateral;Legal patent;Light;Malignant Neoplasms;Maps;Marketing;Medical Electronics;meter;Methods;Microscope;Microscopic;miniaturize;miniaturized device;Modernization;Mohs Surgery;Morphologic artifacts;necrotic tissue;Noise;novel;Nuclear;Operative Surgical Procedures;Optics;Pain;Pathologic;Pathologist;Pathology;pathology imaging;Pathway interactions;Patients;Performance;Perioperative complication;Persons;Phase;phase 2 study;point of care;Postoperative Complications;Procedures;Process;prototype;Reading;Reagent;Reproducibility;Resected;Resolution;Risk;Sampling;Scanning;screening;Screening Result;Sensitivity and Specificity;Signal Transduction;Skin Cancer;Skin Carcinoma;Slice;Slide;Specific qualifier value;Specimen;Specimen Handling;Speed;Squamous cell carcinoma;Staging;Stains;standard of care;success;Surface;Surgeon;Surgical complication;Surgical Pathology;System;Technology;Thick;Time;Tissue Preservation;tissue processing;Tissue Sample;Tissues;Training;treatment choice;tumor;Tumor stage;United States National Institutes of Health;Validation;validation studies;verification and validation;Visual;Work;wound;wound healing

PROJECT_TITLE: Advanced Surgical Pathology Device

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-Z(10)B]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_DEPT: PHYSIOLOGY

PHR: The global objective of this proposal is to investigate the tissue-specific causative role of aberrant mitochondrial Ca2+ uptake in skeletal muscle and motor neuron in Amyotrophic Lateral Sclerosis (ALS) pathogenesis. Specifically, we will determine the impact of aberrant mitochondrial Ca2+ uptake in skeletal muscle and/or motor neuron on the survival, motor neuron loss, exercise performance, muscle force generation, neuromuscular junction structure/function, and intracellular Ca2+ release properties and mitochondrial function in skeletal muscle fibers, at different stage of disease progression in two established mouse models of ALS. Results from this project will provide pre-clinical evidence needed to determine whether excessive mitochondrial Ca2+ uptake in skeletal muscle and motor neuron is a viable therapeutic target for ALS treatment.

PI_NAMEs: WEI-LAPIERRE, LAN  (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Adult;Alleles;ALS pathology;ALS patients;Amyotrophic Lateral Sclerosis;amyotrophic lateral sclerosis therapy;Animals;Attenuated;attenuation;Axon;axonopathy;behavioral study;Bioenergetics;Brain;Buffers;C9ORF72;Cell Death;Cell Membrane Permeability;Cuprozinc Superoxide Dismutase;Defect;Degenerative Disorder;Disease;Disease Progression;Dissection;Distal;DNA-Binding Proteins;Dominant-Negative Mutation;effective therapy;Electron Microscopy;Event;Exercise;extend lifespan;extensor digitorum;Generations;Genes;Genetic;Genetic Models;Homeostasis;Immunohistochemistry;improved;In Situ;in vivo;Measurement;Membrane Potentials;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Molecular;Motor;Motor Neurons;mouse model;Mus;Muscle;Muscle Contraction;Muscle denervation procedure;Muscle Fibers;Muscle function;muscular structure;Mutation;Neurodegenerative Disorders;Neuromuscular Junction;neuron loss;neuronal survival;new therapeutic target;Onset of illness;Outcome;Paralysed;Pathogenesis;Pathologic;Pathology;Patients;Performance;Phenotype;postsynaptic;pre-clinical;preservation;presynaptic;prevent;Property;Reporting;Research;Respiratory Chain;Respiratory Failure;Role;Signal Transduction;Skeletal Muscle;Soleus Muscle;Spinal Cord;Structure;Symptoms;System;Testing;Therapeutic Effect;therapeutic target;Tissues;Transgenic Mice;Treatment Efficacy;uptake;Western Blotting

PROJECT_TITLE: Using mitochondrial Ca2+ uptake as a therapeutic target for ALS

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Clinical Research;Dissemination and Implementation Research;Health Services;Machine Learning and Artificial Intelligence;Patient Safety;Pediatric;Social Determinants of Health

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative In this renewal R01, we will conduct an observational implementation study across 5 health systems to evaluate the fairness and generalizability of the CONCERN predictive model and clinical decision support intervention. We will also explore how CONCERN could leverage pediatric caregiver input in real-time to improve the CONCERN predictive model. In this project we will also research how social determinants of health data and census level data can improve the CONCERN model so that it contributes to more equitable care for patients.

PI_NAMEs: CATO, KENRICK DWAIN;ROSSETTI, SARAH COLLINS (contact)

PROGRAM_OFFICER_NAME: MCNAMARA, KAREN MARIE

PROJECT_TERMS: Academic Medical Centers;Accident and Emergency department;acute care;Adoption;Adult;American;Area;Automobile Driving;Calibration;Caregiver support;Caregivers;Censuses;Characteristics;Childhood;Clinical;clinical decision support;Colorado;Communication;Consolidated Framework for Implementation Research;Country;Data;Data Science;data-driven model;design;Deterioration;Discipline of Nursing;Documentation;Electronic Health Record;Ensure;Equity;Ethnic Origin;Evaluation;Feedback;Foundations;Funding;Gender;Goals;health data;Health system;Hospitalization;Hour;implementation framework;implementation science;implementation study;improved;Inpatients;Intensive Care Units;Intervention;Knowledge;Language;Machine Learning;Maintenance;Measures;Medical;Medical center;medical specialties;Modeling;mortality;Multi-Institutional Clinical Trial;National Institute of Nursing Research;novel;nurse performance;Nurses;Nursing Research;Operative Surgical Procedures;Patient Care;patient oriented;patient population;Patient risk;Patient-Focused Outcomes;Patients;Pattern;pediatric patients;Pediatrics;Performance;Phase;Physicians;Population;Population Characteristics;predictive modeling;Process;programs;Provider;Proxy;Race;Randomized Controlled Clinical Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;response;Risk;risk prediction;Rural;Signal Transduction;Site;social health determinants;Strategic Planning;suburb;System;Testing;Time;Translating;Universities;urban setting;Washington

PROJECT_TITLE: Communicating Narrative Concerns Entered by RNs (CONCERN)

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: ADMINISTRATION

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative The proposed study will assess the feasibility of two novel interventions to tackle important sociocultural and economic barriers to the utilization of routine breast cancer screening by women. In doing so, this study will inform efforts to improve a critical health behavior for women and generate a prototype for addressing the high incidence of breast cancer in low-income settings.

PI_NAMEs: ACHARYA, YUBRAJ  (contact)

PROGRAM_OFFICER_NAME: JALLOW, FATOU

PROJECT_TERMS: Address;Advisory Committees;Affect;Africa South of the Sahara;Age;arm;Attitude;Awareness;Behavior Therapy;Belief;Breast Cancer Detection;Breast Cancer Education;Bundling;Clinic;combat;Consult;cost;Country;Data Collection;Decision Making;design;diabetes education;Diabetes Mellitus;Diagnosis;Disease;Disproportionately impacts women;Early Diagnosis;Economics;Education;Educational Curriculum;Educational Materials;Effectiveness of Interventions;effectiveness testing;Enrollment;Evaluation;Family;Family Planning;Feasibility Studies;Future;Gender;gender behavior;Generations;Ghana;Goals;Government;Head;Health;Health behavior;Health care facility;Health system;high reward;Household;improved;Incidence;Income;innovation;insight;instrument;Intervention;intervention effect;Interview;Low income;male;Malignant Breast Neoplasm;Malignant Neoplasms;Maternal and Child Health;Measures;men;Methods;Monitor;multidisciplinary;Non-Insulin-Dependent Diabetes Mellitus;novel;Participant;Personal Satisfaction;Process;programs;Protocols documentation;prototype;Randomized, Controlled Trials;recruit;Religion;Research;Risk Factors;routine screening;Rural;Sample Size;Scientist;screening;screening program;Self-Examination;Side;Site;social;social culture;social stigma;Social support;Surveys;Survival Rate;Testing;Time;Transportation;Travel;uptake;Visit;Woman;Women's Health;young woman

PROJECT_TITLE: Testing Approaches to Promote Breast Cancer Screening in Rural Ghana

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Human Genome;Rare Diseases

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Molecularly targeted treatments have revolutionized cancer treatment but the development of drug resistance to cancer-directed therapy is a major barrier to improved survival outcomes. This research proposal combines a rationally designed clinical trial with a laboratory-based approach to investigate the efficacy of a molecularly targeted agent in chronic myelomonocytic leukemia and identify potential sources of drug resistance to this agent. These findings will inform novel treatment strategies for chronic myelomonocytic leukemia by circumventing the emergence of drug resistance, leading to better patient outcomes in this poor-risk disease.

PI_NAMEs: PATEL, AMI B (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Affect;Alleles;Allogenic;Award;Bioinformatics;Biology;biomarker identification;Bone Marrow;Bone marrow failure;cancer drug resistance;cancer therapy;career;career development;Career Mobility;CBL gene;Cell Line;Cells;Chronic Myelomonocytic Leukemia;Clinical;clinical investigation;Clinical Investigator Award;clinical trial implementation;Clinical Trials;Clinical Trials Design;cohort;combinatorial;Comprehensive Cancer Center;Correlative Study;CRISPR/Cas technology;Cytokine Receptors;Dedications;design;Development;Disease;Disease remission;disorder risk;Drug resistance;drug resistance development;Drug Targeting;Dysplasia;effective therapy;efficacy testing;Elderly;Eligibility Determination;Ensure;Environment;Exhibits;exome sequencing;experience;Exposure to;FLT3 gene;Future;Genetic;genome editing;Goals;Hematologic Neoplasms;Hematologist;high risk;High-Throughput Nucleotide Sequencing;improved;In complete remission;In Vitro;in vivo;Individual;inhibitor;Institution;International;Interruption;Investigation;JAK2 gene;kinase inhibitor;KRAS2 gene;Laboratories;Leukemic Cell;Malignant Neoplasms;Mentors;Methodology;Mitogen-Activated Protein Kinase Kinases;Mitogen-Activated Protein Kinases;Mitogens;Molecular Target;molecular targeted therapies;mortality;Mus;mutant;Mutate;Mutation;Myelogenous;Myeloproliferative disease;NF1 gene;novel;older adult;Oncologist;open label;Oral;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;phase 2 study;Phase I/II Trial;Phase II Clinical Trials;Phosphotransferases;Physicians;Pre-Clinical Model;preclinical study;prevent;programs;Proliferating;Protein Tyrosine Kinase;PTPN11 gene;Ras Inhibitor;rational design;Receptor Signaling;Refractory;Relapse;Research;Research Personnel;Research Proposals;Resistance;resistance mechanism;response;Sampling;Scientist;Signal Transduction;Site;skills;small hairpin RNA;Somatic Mutation;Source;standard care;Stem cell transplant;Structure;success;survival outcome;Symptoms;targeted agent;Techniques;Testing;Therapeutic;Time;Training;transcriptome sequencing;Translational Research;translational research program;Transplantation;treatment response;treatment strategy;Universities;Utah;Validation

PROJECT_TITLE: Mechanisms of resistance to MEK Inhibition in RAS-pathway activated chronic myelomonocytic leukemia

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: TALLAHASSEE

ORG_DEPT: BIOLOGY

ORG_NAME: FLORIDA STATE UNIVERSITY

PHR: PROJECT NARRATIVE Sixty-five percent of Americans are overweight; unwanted weight gain induces an increased workload on the heart and circulation, increases insulin resistance, and precipitates type II diabetes. This proposal will use genome editing strategies or nanoparticle-guided drug inhibitors to increase the excitability of the neurons in the olfactory bulb. We will test whether this increased excitation can lower body weight, prevent weight gain when consuming fatty diets, lower blood glucose, and increase metabolic use of fats as energy substrates.

PI_NAMEs: FADOOL, DEBRA ANN (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Acceleration;Action Potentials;American;Anosmia;Area;Attenuated;biophysical properties;Blood Glucose;Body fat;Body Weight;Body Weight decreased;Body Weights and Measures;Brain;Brain region;Cell Nucleus;Cells;Chronic;Circulation;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;Consumption;Country;Cre lox recombination system;CRISPR/Cas technology;Diabetes Mellitus;Diet;diet-induced obesity;Drops;Educational workshop;Electrophysiology (science);energy balance;Energy Metabolism;Epidemic;Equilibrium;Excision;Exercise;experimental study;Fatty acid glycerol esters;food consumption;FOS gene;Frequencies;Functional disorder;Genes;Genetic;genome editing;Glucose;glucose tolerance;Goals;Health;Heart;Homeostasis;Hypothalamic structure;improved;Incidence;inhibitor;Insulin Resistance;interdisciplinary approach;Intervention;Knockout Mice;Knowledge;Kv1.3 potassium channel;Lead;Link;Maps;Metabolic;Metabolic dysfunction;metabolic phenotype;Metabolism;mouse model;Mus;nanoparticle;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute on Deafness and Other Communication Disorders;neural;neuronal excitability;Neurons;Neurosecretory Systems;Non-Insulin-Dependent Diabetes Mellitus;novel;nutrition;Obesity;obesity prevention;Odors;olfactory bulb;Olfactory Pathways;olfactory sensory neurons;Output;Overweight;Pattern;Pharmaceutical Preparations;Physiological;Physiology;Play;Potassium Channel;prevent;Property;Quantum Dots;Reporting;Research;Resistance;respiratory;restoration;Role;Sensory;sensory system;Serology;Signal Transduction;Slice;Smell Perception;Synapses;System;Testing;Therapeutic Intervention;total energy expenditure;Vestibule;Viral;voltage;Washington;Weight Gain;Work;Workload

PROJECT_TITLE: Probing the link between sensory systems and metabolism to prevent obesity

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Prevention;Racial and Ethnic Minority Health Research;Serious Mental Illness;Social Determinants of Health;Women's Health Research

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Although there are interventions aimed at preventing postpartum depression, few have been tested with immigrant Latinas and existing interventions are limited by their reliance on in-person delivery. This project will test whether the evidence-based Mothers and Babies postpartum depression preventive intervention, adapted for delivery via a virtual modality and for immigrant Latinas, will prevent postpartum depression and improve parenting practices.

PI_NAMEs: PLATT, RHEANNA EDITH;TANDON, SHIV DARIUS (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: acceptability and feasibility;Address;Adoption;Affect;aged;Area;Cellular Phone;Characteristics;Child;Child Rearing;Clinical;Code;Cognitive Therapy;Communities;comparison control;Consolidated Framework for Implementation Research;contextual factors;Counseling;Data;depression prevention;depressive symptoms;Discrimination;disparity reduction;dosage;early childhood;Educational process of instructing;Effectiveness;effectiveness evaluation;effectiveness-implementation RCT;Electronics;Emotions;Enrollment;Ethnic Population;evidence base;Evidence based intervention;Exhibits;experience;family support;food insecurity;Future;group intervention;health care settings;High Risk Woman;Immigrant;Impairment;implementation determinants;implementation outcomes;implementation process;implementation science;implementation strategy;improved;Individual;Informal Social Control;informant;Insurance;Interpersonal Relations;Intervention;intervention delivery;intervention effect;intervention participants;Interview;Language;laptop;Latin American;Latina Population;Learning;Maintenance;Maryland;Measures;Mental Depression;Mental Health;Mental Health Services;Methods;Modality;mood regulation;Mothers;multidisciplinary;National Institute on Minority Health and Health Disparities;Outcome;Participant;participant enrollment;Patient Self-Report;Perinatal;perinatal women;Persons;Pilot Projects;pilot test;Population;post intervention;postnatal;Postpartum Depression;Poverty;pregnant;prevent;preventive intervention;programs;Provider;racial population;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Reporting;Research;Resources;Risk;Risk Factors;Role;Schools;Self Efficacy;Series;service providers;Services;Site;skills;social health determinants;Social Network;social stigma;Social support;Strategic Planning;Stress;Structure;Surveys;Tablets;Testing;Text Messaging;theories;therapy design;Training;Trauma;trial enrollment;United States;United States Preventative Services Task Force;virtual;virtual delivery;virtual group;virtual intervention;virtual platform;Woman

PROJECT_TITLE: Preventing postpartum depression among immigrant Latinas through a virtual group intervention

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE COUNTY

ORG_STATE: MD

PHR: Narrative Light has a profound effect on human physiology and behavior, including synchronizing circadian rhythms, sleep, mood, memory and learning. The intrinsically photosensitive retinal ganglion cells, which express a light responsive protein, melanopsin, play a key role in these light-dependent behaviors. The goal of this proposed research is to understand the diversity of melanopsin-based signaling pathways, their regulation by dopamine, and their involvement in light-dependent behaviors.

PI_NAMEs: BROWN, RONALD LANE;ROBINSON, PHYLLIS R (contact);SIVYER, BENJAMIN M;ZHAO, HAIQING

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Address;Affect;Amacrine Cells;Animals;Attenuated;Behavior;behavior measurement;Behavioral;behavioral outcome;Biochemical;Brain;Cell Culture System;Cell Culture Techniques;Cell Physiology;Cells;circadian;circadian regulation;Circadian Rhythms;Collection;conditional knockout;contrast enhanced;Cyclic AMP-Dependent Protein Kinases;Data;Detection;Disabling;Dopamine;Dopamine Receptor;driving behavior;Electrophysiology (science);expectation;experimental study;Family;Genetic;Goals;Health;Human;in vivo;Individual;insight;interdisciplinary approach;Ion Channel;Knock-in Mouse;knockout animal;Knowledge;Label;Learning;Light;Mammals;Measures;Mediating;melanopsin;Memory;Modeling;Molecular;Moods;mouse model;Mus;Mutate;Neuromodulator;novel strategies;Outcome;Pathway interactions;Pattern;Performance;Phosphorylation;Phosphorylation Site;Phototransduction;Physiological;Physiology;Play;Population;Population Heterogeneity;prevent;Proteins;Publications;Pupil light reflex;receptor;Regulation;Reporting;Research;response;Retina;Retinal Ganglion Cells;Retinal Photoreceptors;Role;Signal Pathway;Signal Transduction;Sleep;Stratification;Synapses;System;transcriptome;Vertebrate Photoreceptors;Virus;Work

PROJECT_TITLE: Regulation of the intrinsic melanopsin-based light response in ipRGCs

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative We recently discovered a novel biophysical action for microRNAs (miRs) beyond the classical mechanism of RNA interference (RNAi); it is now important to explore if the biophysical modulation of miRs is a general regulatory mechanism of cardiac ion channels and to demonstrate the specific contribution of this biophysical modulation by miRs in regulating the homeostasis of the heart. In this study, we have identified and will continue to study the mechanisms of the biophysical modulations between multiple cardiac ion channels (e.g., Kir2.1, Kir6.2 and Cavb2) and miR1 or newly-identified miRs; we will also reveal the specific physiological impact of miR1’s biophysical action in 14G-mutation homozygous transgenic mice in which the biophysical action of miR1 is specifically deleted while the RNAi is maintained. Our discoveries have pioneered a new field in miR biology expanding the scientific significance of miRs and providing a mechanistic foundation and new avenues for anti-arrhythmic therapy.

PI_NAMEs: DESCHENES, ISABELLE  (contact);FU, JIDONG

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Acute;Adult;Age;Anti-Arrhythmia Agents;Antibodies;Arrhythmia;Binding;Biological;Biological Assay;Biology;Biophysical Process;Biophysics;Biotinylation;Cardiac;Cardiac Electrophysiologic Techniques;Cardiac Myocytes;cardiogenesis;Consensus;CRISPR/Cas technology;crosslink;Data;Development;Disease;Electrophysiology (science);Environment;Event;Evolution;Foundations;Funding;Genes;Heart;Heart Abnormalities;Heart failure;heart function;Homeostasis;Homo;Human;Immunoprecipitation;improved;innovation;inward rectifier potassium channel;Ion Channel;Ion Channel Protein;Kir2.1 channel;Knock-out;Knowledge;Mass Spectrum Analysis;Mediating;Medicine;Membrane Potentials;Membrane Proteins;Messenger RNA;MicroRNAs;Molecular;mortality;Mus;mutant;Mutate;Mutation;Neonatal;novel;Nucleotides;overexpression;Physiological;Physiology;Play;postnatal;Potassium;Protein Binding Domain;protein expression;Proteins;Publishing;Regulation;Rest;RNA;RNA Interference;Role;Single Nucleotide Polymorphism;Small RNA;Solid;Testing;tool;transcriptome sequencing;Transgenic Mice;Transgenic Organisms;Untranslated RNA;Variant;Weaning

PROJECT_TITLE: Biophysical Modulation of Cardiac Ion Channels by MicroRNA

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Infectious Diseases;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative To fill the gap in mechanistic understanding of the delayed effects of acute radiation exposure (DEARE) on the immune system, this study will test our hypothesis that aberrant metabolic reprogramming in T cells is pivotal for mid to late immune dysfunction in survivors of the acute radiation syndrome. We will also investigate the late effects of mixed neutron/photon radiation on T cells’ metabolism, given that in a real-life nuclear incident, an exposure to mixed fields of neutrons and photon is highly likely. Additionally, interventions using senescent cell ablation approaches will be assessed for its feasibility to prevent adverse effects in T cells after radiation.

PI_NAMEs: FORNACE, ALBERT J (contact)

PROGRAM_OFFICER_NAME: WINTERS, THOMAS A

PROJECT_TERMS: Ablation;Acceleration;Acute;Address;Adverse effects;Affect;amino acid metabolism;Animals;Antigens;atomic bomb;Bacteria;Bacterial Infections;Biological;Biological Markers;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Aging;Cell Physiology;Cellular Metabolic Process;Cellular Structures;cohort;Data;Dose;Energy Metabolism;epidemiologic data;Event;Excision;Exposure to;fatty acid oxidation;Feedback;Foundations;Functional disorder;Gene Expression;Genes;Genetic;Glycolysis;Homeostasis;Immune;immune function;Immune system;Immune System Diseases;Immunity;immunosenescence;Impairment;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Intervention;Ionizing radiation;irradiation;Late Effects;Life;lipidomics;Listeria monocytogenes;Lymphoid;Lymphoid Tissue;Measurable;Mediating;Memory;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Mitochondria;Modeling;mouse model;Mucous Membrane;multiorgan injury;Mus;Neutrons;Nuclear Accidents;pathogen;Pathway interactions;pharmacologic;Phenotype;Photons;Physiological;Play;Population;Positioning Attribute;premature;prevent;Prevention strategy;preventive intervention;Process;Publications;Publishing;Radiation;radiation effect;Radiation exposure;radiation mitigator;Radiation Toxicity;radioresistant;Regulation;Reporting;response;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Serum;Signal Transduction;small molecule;Spleen;Survivors;synergism;T cell response;T memory cell;T-Cell Activation;T-Cell Development;T-Lymphocyte;Testing;Tissues;Uncertainty;Virus

PROJECT_TITLE: Metabolic impairment plays a critical role in radiation-induced T cell immune dysfunction


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: TSRL, INC.

ORG_STATE: MI

PHR: Infections due to antibiotic resistant bacteria are spreading throughout the world and represent a major threat to public health. The goal of this project is to develop a new antibiotic acting by a novel mechanism that will provide a new option for treating drug-resistant bacterial infections.

PI_NAMEs: LIPKA, ELKE  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Accident and Emergency department;Acute;Address;aging population;Anaerobic Bacteria;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;Bacteremia;Bacteria;Bacterial Antibiotic Resistance;Bacterial Drug Resistance;Bacterial Infections;Bacterial Proteins;beta-Lactams;Biological Availability;Characteristics;Chemistry;Chronic Obstructive Pulmonary Disease;Clinical;comparative efficacy;Cytochrome P450;Cytochromes;cytotoxicity;dalbavancin;Data;Death Rate;design;Development;Diabetes Mellitus;Dose;Drug Interactions;Drug resistance;Drug usage;efficacy outcomes;Enrollment;Ensure;Enterococcus faecium;Enzymes;exposed human population;Exposure to;Fluoroquinolones;Formulation;Foundations;Goals;Gram-Positive Bacterial Infections;Grant;Growth;Health care facility;Healthcare Systems;Hospitalization;Hospitals;Human;Hypersensitivity;improved;In Vitro;in vivo;in vivo evaluation;Incidence;Individual;Infection;inhibitor;Intermediate resistance;Intravenous;Investigational Drugs;Investigational New Drug Application;Kidney Failure;Kilogram;Laboratory Research;Lead;lead candidate;Linezolid;Macrophage;Mammalian Cell;Medical;member;Metabolic;methicillin resistant Staphylococcus aureus;Methionine-tRNA Ligase;Methodology;Microbiology;Minimum Inhibitory Concentration measurement;Mitochondria;Modeling;mouse model;Mus;new chemical entity;novel;novel antibiotic class;novel therapeutics;Oral;Oral Administration;Organism;oritavancin;Oxazolidinones;pathogen;Patients;Performance;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pharmacology;Pharmacology Study;Phase;pleuromutilin;pre-clinical research;preclinical development;Preclinical Drug Development;product development;Program Development;programs;Protein Biosynthesis;Public Health;Rattus;Reaction;recurrent infection;Regimen;Research;research and development;Resistance;resistance frequency;resistance mechanism;Risk;Risk Factors;Rodent;Route;Safety;safety study;scale up;Selective Serotonin Reuptake Inhibitor;skills;Skin;Small Business Innovation Research Grant;small molecule;Staphylococcal Infections;Staphylococcus aureus;Streptococcal Infections;Streptococcus;Streptococcus pyogenes;Structure;subcutaneous;systems research;Testing;Tetracyclines;Therapeutic;Thigh structure;Toxic effect;Toxicology;United States;Universities;Vancomycin;Vancomycin resistant enterococcus;Vancomycin-resistant S. aureus;Visit;Washington

PROJECT_TITLE: Development of MRS-2541, a methionyl-tRNA synthetase inhibitor, for Gram positive bacterial infections.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-F(12)]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Hematology;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Orphan Drug;Pneumonia;Pneumonia and Influenza;Rare Diseases;Sepsis;Social Determinants of Health

ORG_CITY: Murray

ORG_NAME: IHC HEALTH SERVICES, INC.

PHR: Project Narrative The Intermountain West-Atlantic Center (InterACT) brings together four technically experienced, high-enrolling sites to participate in the APS Phenotypes Consortium. InterACT will use robust statistical methods to phenotype patients with Acute Respiratory Distress Syndrome (ARDS), pneumonia, and sepsis in two broad proposals that incorporate target trial emulation to confirm phenotypes. The Consortium-wide proposal focuses on clinical data and inflammatory cytokines, while the Center-specific proposal investigates hyaluronan and tissue injury and repair pathways.

PI_NAMEs: BARKAUSKAS, CHRISTINA ELEANOR;BROWN, SAMUEL MORRIS (contact);NEEDHAM, DALE MURRAY;SCHARFSTEIN, DANIEL OSCAR

PROJECT_TERMS: Accounting;Acute;Acute Respiratory Distress Syndrome;Address;Biological;Biological Markers;Biology;Clinical;clinical application;clinical care;Clinical Data;Clinical Trials;cohort;common treatment;computer scientist;COVID-19/ARDS;Critical Illness;cytokine;Data;Data Analyses;Data Collection;design;Disease;disease phenotype;Enrollment;experience;Future;Goals;Heterogeneity;Hyaluronan;immune activation;immunoregulation;improved;improved outcome;Inflammation;Inflammatory;injury and repair;innovation;Intensive Care Units;International;Investigation;Lead;Machine Learning;machine learning method;Measures;Mechanical ventilation;Methodology;Methods;Molecular;molecular marker;mortality;Noise;novel;Outcome;Output;participant enrollment;Pathologic;Pathway interactions;patient response;Patient-Focused Outcomes;Patients;Pattern;Pharmacotherapy;Phenotype;Play;Pneumonia;Population;Process;prospective;Receptor Activation;receptor for advanced glycation endproducts;Records;Recovery;Role;Sepsis;sepsis induced ARDS;Signal Transduction;Site;social culture;social determinants;statistical and machine learning;Statistical Methods;stem cells;Subgroup;Supportive care;Syndrome;Target Populations;targeted treatment;Techniques;Therapeutic;Therapeutic Trials;tissue injury;tissue repair;Toll-like receptors;treatment response;Validation;Variant;Work

PROJECT_TITLE: The Intermountain West-Atlantic Center (InterACT) for the APS Phenotyping Consortium


NIH_SPENDING_CATS: Biotechnology;Cancer;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases;Skin Cancer

ORG_CITY: WINCHESTER

ORG_NAME: BOSTON IMMUNE TECHNOLOGIES AND THERAPEUTICS, INC.

PHR: PROJECT NARRATIVE  TNFR2 is an extremely promising target for cancer therapy, especially in CTCL, where it reportedly act as an  oncogenic driver. However, strategies aimed at TNFR2 targeting fail to shut down its pro-survival signaling. BITT  is developing the first-in-class dominant antagonist to TNFR2 with potent anti-tumor effect in CTCL, and whose  use can easily be expanded for the treatment of several cancers.

PI_NAMEs: OLIVIER, KENNETH  (contact)

PROGRAM_OFFICER_NAME: BOZZA, WILLIAM PATRICK

PROJECT_TERMS: antagonist;anti-tumor immune response;Antibodies;Antibody Therapy;antitumor effect;Autoimmunity;Benchmarking;Binding;Boston;cancer cell;cancer infiltrating T cells;Cancer Patient;cancer therapy;Cancerous;Capital;Cells;cGMP production;Clinical;Clinical Trials;Colon Carcinoma;Cutaneous T-cell lymphoma;Cyclic GMP;Data;design;Development;dimer;Dose;Drug Kinetics;Effector Cell;Evaluation;Formulation;Frequencies;Funding;Future;Growth;Guidelines;Health;Health Care Costs;Health Expenditures;Human;Immune;Immune checkpoint inhibitor;Immune system;Immunooncology;Immunotherapy;In Vitro;in vitro activity;in vivo;Infiltration;innovation;interest;International;Investigational Drugs;Investigational New Drug Application;large scale production;Macaca fascicularis;Malignant neoplasm of ovary;Malignant Neoplasms;manufacturing run;Marketing;Mediating;Molecular Target;Monoclonal Antibodies;Mus;New Drug Approvals;novel strategies;novel therapeutic intervention;novel therapeutics;Oncogenes;Oncogenic;overexpression;Patients;Persons;pharmacologic;Pharmacologic Substance;Pharmacology and Toxicology;Phase;pre-clinical;prevent;Process;Production;Productivity;programmed cell death protein 1;programs;receptor;Receptors, Tumor Necrosis Factor, Type II;Regulatory Affairs;Regulatory T-Lymphocyte;Reporting;research clinical testing;Resistance;Safety;Sampling;Secure;selective expression;Signal Transduction;Small Business Innovation Research Grant;Societies;Surface;targeted cancer therapy;targeted treatment;Technology;Testing;Therapeutic;therapeutic target;therapy outcome;Time;Tissues;TNFRSF1A gene;tool;Toxic effect;Toxicology;tumor;tumor microenvironment;tumor necrosis factor receptor binding;Validation;validation studies

PROJECT_TITLE: Preclinical toxicology and pharmacology evaluation of a newTNFR2 antagonistic monoclonal antibody for CTCL therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-L(12)B]


NIH_SPENDING_CATS: Genetics;Human Genome;Mental Health;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE The human central nervous system (CNS) is characterized by an increase in cell diversity as well as size, features which underlie our amazing cognitive and behavioral capacity. Neural progenitor cells directly dictate both the size and cell diversity of the CNS; understanding how the human neural progenitor cell population differs from that of mice or monkeys is therefore fundamental to understanding what makes our nervous systems unique. This project will profile and compare neural progenitor cell diversity in humans, monkeys and mice, and thereby identify human- or primate-specific progenitor cells, as well as characterize how they contribute to CNS size and cell diversity.

PI_NAMEs: JANG, SUMIN  (contact)

PROGRAM_OFFICER_NAME: CHURCHILL, JAMES D

PROJECT_TERMS: 3-Dimensional;Achievement;Activities of Daily Living;Address;Adult;Amaze;Astrocytes;ATAC-seq;Behavioral;Biological Assay;Biological Models;BRAIN initiative;Catalogs;Cell model;Cell Physiology;cell type;Cells;Central Nervous System;Cercopithecidae;Cerebral cortex;Characteristics;Cleavage Under Targets and Release Using Nuclease;Coculture Techniques;Cognitive;cognitive ability;comparative;Complex;Computational Biology;Computational Technique;Data;Development;differentiation in vitro;disease model;Dorsal;Evolution;Foundations;Gene Expression;Gene Expression Profile;Genes;Genetic Recombination;Goals;Human;human model;human RNA sequencing;In Vitro;in vitro Model;induced pluripotent stem cell;insight;Investigation;Label;Limb structure;Link;Macaca;Mammals;Molecular;Monkeys;Motor;Motor Neurons;Motor Skills;Mus;nerve stem cell;Nervous System;neurodevelopment;neurogenesis;Neuroglia;Neuronal Differentiation;Neurons;nonhuman primate;novel;Organoids;Output;Pathology;Pathway interactions;Pattern;Physiology;Pluripotent Stem Cells;Population;Population Heterogeneity;Population Sizes;Postdoctoral Fellow;Primates;progenitor;programs;Protocols documentation;Regulatory Element;Research;Research Personnel;Research Training;Rodent;Role;single-cell RNA sequencing;Source;Spinal;Spinal Cord;Standardization;stem cell fate specification;stem cell population;stem cells;System;temporal measurement;Testing;tool;Training;transcription factor;Transplantation;Xenograft procedure

PROJECT_TITLE: Identifying human-specific neural progenitors and their role in neurodevelopment


NIH_SPENDING_CATS: Cancer;Genetics;Rare Diseases

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative / Relevance: (3 sentences) Cancer is the 2nd leading cause of death in the US but importantly, the vast majority of cancer-associated mortality is not due to primary tumor growth but to cancer metastasis. Analysis of the changing metabolome during epithelial-to-mesenchymal transition (EMT), a developmental program hijacked by cancer cells to acquire metastatic and drug resistance properties, has led to the novel discovery that methylmalonic acid (MMA), a by- product of propionate metabolism, is rapidly produced and secreted by tumor cells, driving increased invasiveness and chemoresistance in both autocrine and paracrine manners. We propose to: (i) define how MMA production is regulated in cancer, (ii) determine how secreted MMA activates cancer-associated fibroblasts (CAFs) and (iii) characterize how CAFs in turn secrete factors that further promote tumor metastasis with the ultimate goal of defining a new cancer regulatory process, new biomarkers and new potential targets for drug discovery that are needed for personalized therapeutic interventions in metastatic cancer. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

PI_NAMEs: BLENIS, JOHN  (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Address;Age;age related;Area;autocrine;Automobile Driving;Biochemical;Biological Markers;Biological Process;Biology;biomarker identification;Branched-Chain Amino Acids;Breast Cancer Cell;Cancer Biology;cancer cell;cancer therapy;Cause of Death;Cells;Cessation of life;Chemoresistance;Communication;Coupled;Data;Development;Dicarboxylic Acids;Disease;Disseminated Malignant Neoplasm;DNA Sequence Alteration;drug discovery;Drug resistance;Drug Targeting;Elderly;Enzymes;Epigenetic Process;epimerase;Epithelial Cells;epithelial to mesenchymal transition;expectation;Expression Profiling;extracellular;Fatty Acids;Fibroblasts;Gene Expression;Genetic;Genetic Transcription;Goals;Hereditary Disease;Hypoxia;improved;In Vitro;in vivo;in vivo Model;Inborn Errors of Metabolism;insight;Knowledge;Link;lung cancer cell;Malignant Neoplasms;MAPK1 gene;Mesenchymal;Metabolic;Metabolic dysfunction;Metabolic Pathway;Metabolism;metabolome;metabolomics;Methylmalonic Acid;methylmalonic aciduria;methylmalonyl-CoA decarboxylase;Methylmalonyl-CoA Mutase;methylmalonyl-coenzyme A;Molecular;mortality;Neoplasm Metastasis;neoplastic cell;non-genetic;novel;nutrient deprivation;Oncology;paracrine;Pathway interactions;Patients;personalized therapeutic;Persons;Phenotype;Physiological Processes;prevent;Primary Neoplasm;Process;Production;programs;Property;Propionates;propionyl-coenzyme A;Proteomics;Publishing;Regulator Genes;Serum;Signal Transduction;Solid Neoplasm;targeted treatment;Testing;Therapeutic Intervention;therapeutic target;Time;transcriptomics;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Work;wound healing

PROJECT_TITLE: Propionate metabolism and cancer

STUDY_SECTION: CCB

STUDY_SECTION_NAME: Cancer Cell Biology Study Section[CCB]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Aging;Biotechnology;Clinical Research;Disability Research;Genetics;Hematology;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Precision Medicine;Prevention;Rare Diseases;Rehabilitation;Sepsis

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Acute respiratory distress syndrome (ARDS), pneumonia, and sepsis, syndromes which cause major mortality and persistent debility among survivors, share many common pathophysiologic features yet also display substantial heterogeneity between individuals. A deeply phenotyped cohort with rich clinical data and broad molecular profiling during both the acute illness and recovery periods will allow us to investigate for patterns of shared host response, provide clues for why certain patients act differently, and help move the field closer to targeted precision therapy. We propose careful molecular and clinical characterization of a cohort of sepsis and pneumonia patients at high risk for ARDS to better understand how these syndromes overlap and which molecular features best predict organ failure, survival, and long term disability.

PI_NAMEs: HARHAY, MICHAEL OSCAR;MEYER, NUALA JENNINGS (contact)

PROJECT_TERMS: 2019-nCoV;Acute;Acute Renal Failure with Renal Papillary Necrosis;Acute Respiratory Distress Syndrome;Address;Age;Autoantibodies;Biological;Blood Vessels;candidate marker;Cells;Cessation of life;Characteristics;Chronic disability;Clinical;clinical center;Clinical Data;clinical phenotype;Cognitive;cohort;Cohort Studies;Collaborations;comorbidity;COVID-19 patient;Critical Illness;Critical Pathways;Data;Data Collection;Debility;Dimensions;disability;Emergency Situation;Emotional;Enrollment;Etiology;Event;Failure;Fibrinolysis;Flow Cytometry;functional status;Gene Expression;Genetic Transcription;Genomics;Glycocalyx;Health;Heterogeneity;high dimensionality;high risk;Hospitalization;Human;Human Resources;Immune;immune health;Immune response;Immunologic Markers;improved;Individual;individual response;inflammatory marker;Informatics;Infrastructure;Injury;Intensive Care Units;Intervention;Investigation;Joints;Leukocytes;Long term disability;Longitudinal cohort study;Lymphoid;Machine Learning;Malignant Neoplasms;Mediating;Mediation;Mendelian randomization;Methods;Modeling;Molecular;molecular marker;molecular phenotype;Molecular Profiling;molecular subtypes;Morbidity - disease rate;mortality;mortality risk;multiple omics;Myelogenous;Myelopoiesis;nerve injury;neuromuscular;novel;Organ failure;Organ Survival;Outcome;pathogen;Pathway interactions;Patients;Pattern;performance tests;peripheral blood;personalized medicine;pharmacologic;Pharmacotherapy;Phenotype;Physiological;Plasma;Pneumonia;Population;Positioning Attribute;Precision therapeutics;Prevention;Productivity;prognostic;Proteins;Proteome;Proteomics;Quality of life;Recording of previous events;Recovery;Reporting;Reproducibility;response;Risk Assessment;Risk Factors;Role;sarcopenia;Sepsis;septic patients;Severities;Site;skills;Source;Stratification;Stream;success;Survivors;Syndrome;Testing;Time;tool;trait;transcriptomics;treatment response;unsupervised clustering;vascular contributions;Vascular Diseases;vascular factor;vascular injury;Vascular Permeabilities;Work

PROJECT_TITLE: Phenotyping  ARDS, Pneumonia, and Sepsis over time to elucidate shared and distinct trajectories ofillness and recovery


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative

PHR: NARRATIVE Endoplasmic reticulum (ER)-to-mitochondria Ca2+ transfer mediated by the inositol triphosphate receptor (InsP3R) Ca2+ release channels and the mitochondrial Ca2+ uniporter (MCU) Ca2+ uptake channel, plays important roles in many cell physiological processes. We will use powerful biophysical approaches to study the permeation and gating behaviors of both ion channels in their native membrane environments to provide a detailed understanding of the ion permeation and gating kinetics of both ion channels, providing a quantitative understanding of ER-to-mitochondria Ca2+ transfer in health and disease, including cancer and Alzheimer's disease.

PI_NAMEs: FOSKETT, JAMES KEVIN (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Address;Agonist;Alzheimer's Disease;Behavior;Biochemical;biophysical techniques;Biophysics;cancer cell;Cell Physiology;cell type;Cells;Cellular Metabolic Process;Cessation of life;Citric Acid Cycle;Complex;Cytoplasm;Disease;Electrons;Electrophysiology (science);Endoplasmic Reticulum;Environment;familial Alzheimer disease;Goals;Health;Heart;Individual;Inner mitochondrial membrane;inorganic phosphate;Inositol;insight;Ion Channel;Ions;Kinetics;Life;Malignant Neoplasms;Mediating;Membrane;Microscopic;Mitochondria;Mitochondrial Proteins;Molecular;Outcome;Oxidative Phosphorylation;Oxidoreductase;patch clamp;Pathway interactions;Physiological;Physiological Processes;Physiology;Play;Positioning Attribute;Production;Property;Proteins;receptor;Regulation;Role;Signal Pathway;Signal Transduction;Structure;System;Techniques;tripolyphosphate;uptake

PROJECT_TITLE: Molecular physiology of intracellular InsP3R and MCU ion channels

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurosciences;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: NEWARK

ORG_NAME: RUTGERS THE STATE UNIV OF NJ NEWARK

ORG_STATE: NJ

PHR: Project Narrative Decades of research have taught us that addiction is, indeed, a disorder of dysregulated neural circuitry. Using a combination human electrophysiology, computational modeling, real-time signal processing, and noninvasive brain stimulation, the proposed research seeks to develop a new brain-based cognitive intervention (EEG-informed closed-loop TMS system) aimed to correct the aberrant reward processes that sustain substance use disorders. Providing current treatment programs with a highly effective brain-based intervention for reward-related processes involved in both nicotine use disorder and other substance-related disorders will help reduce the major burden addiction places on the US healthcare system.

PI_NAMEs: BAKER, TRAVIS E. (contact);HEADLEY, DREW BATTENFIELD

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: addiction;Adopted;Adult;Affective;Algorithms;Animal Model;Anterior;Behavior;Behavioral;Biological Markers;Brain;brain based;Cigarette;cigarette craving;Clinical;clinical practice;Cognitive;cognitive ability;Computer Models;Consumption;craving;Data;Decision Making;Disease;Dopamine;Dorsal;drug seeking behavior;Educational process of instructing;efficacy testing;Electroencephalography;Electrophysiology (science);Exposure to;Feedback;Goals;Health;Healthcare Systems;Hour;Human;improved;Individual;innovation;Intervention;Investigation;Knowledge;Lateral;Left;Length;Link;Measures;Mediating;Methods;Monitor;neural;neural circuit;Neurocognitive;Neurocognitive Deficit;neuroregulation;nicotine cue;Nicotine Dependence;nicotine treatment;Nicotine Use Disorder;noninvasive brain stimulation;novel;novel therapeutics;operation;Outcome;Pathway interactions;Patients;Pattern;Performance;Pharmaceutical Preparations;Phase;Physiologic pulse;Play;Prefrontal Cortex;Process;Protocols documentation;repetitive transcranial magnetic stimulation;Research;response;Rest;reward circuitry;Rewards;Robotics;Role;signal processing;Signal Transduction;Site;Smoker;smoking cue;Substance Use Disorder;substance use treatment;Substance-Related Disorders;success;System;Testing;Therapeutic Effect;Time;Training;Transcranial magnetic stimulation;Treatment Efficacy;treatment program;virtual;Work

PROJECT_TITLE: A novel therapeutic application of closed-loop neuromodulation of the brain reward system in nicotine use disorder


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Suicide;Suicide Prevention;Violence Research

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Longtime tribal-academic research partners will optimize and evaluate NATIVE-RISE, a systems level strategy to suicide prevention that combines service-ready tools based on predictive analytics with risk-stratified evidence-based care for Native American adults. They will use a Hybrid Type-III stepped wedge cluster randomized trial and mixed methods to improve the reach of Brief Contact Interventions, evidence-based suicide prevention approaches shown to reduce suicide attempts and deaths. Implementing predictive analytics and risk-stratified care to help extend the reach of evidence-based suicide prevention programs to communities with the highest needs is paramount to reducing related health disparities.

PI_NAMEs: HAROZ, EMILY  (contact)

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: Address;Administrator;Adult;Algorithms;American Indians;Apache Tribe;Caring;Case Management;Case Manager;Cessation of life;Chronic;Clinic;Clinical;Cluster randomized trial;Communities;community based participatory research;cost;COVID-19 impact;COVID-19 pandemic;design;Disparity;economic cost;Effectiveness;effectiveness evaluation;enhanced care;evidence base;Evidence based intervention;Exercise;experience;Funding;Funding Opportunities;Genocides;Goals;Health;health care service;health care settings;health disparity;health equity;Health Personnel;Health Services;Health system;Healthcare;Healthcare Systems;high risk;Human Resources;Hybrids;implementation barriers;implementation intervention;implementation trial;improved;Individual;Inequity;innovation;Intervention;intervention cost;Knowledge;Life;Mediator;Mental Health Services;Methods;Modeling;National Institute of Mental Health;Native American population;Native American Tribe;Native Americans;Navajo;Patients;personalized care;pilot test;Population;Positioning Attribute;Predictive Analytics;predictive modeling;Prevention;Prevention approach;Prevention program;prevention service;Prevention strategy;Process;program costs;programs;Provider;Qualitative Methods;racial population;Randomized;reducing suicide;Research;Resources;Risk;risk prediction;risk stratification;Rural;Rural Community;scale up;Science;Service delivery model;Services;Strategic Planning;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;System;Testing;Time;tool;Translating;Trauma;tribal community;tribal healthcare;tribal member;Tribes;Trust;United States Indian Health Service;White Mountain Apache;Work;Workload;Youth

PROJECT_TITLE: NATIVE RISE-Risk Identification for Suicide and Enhanced care for Native Americans


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;HIV/AIDS;Heart Disease;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE People with human immunodeficiency virus (HIV) are at increased risk for heart disease, and new treatments are needed to help prevent heart attacks and death in this population. This research program proposes to evaluate new biomarkers in the blood and imaging to help identify factors linked to heart disease in HIV patients, an important public health problem. The study also proposes to focus on sex differences in heart disease risk in HIV and provide new treatment options to prevent and treat heart disease with a focus on women.

PI_NAMEs: HAYS, ALLISON G (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: Affect;Age;Agonist;Atherosclerosis;Biological;Biological Markers;Blood;Blood Vessels;Cardiology;Cardiometabolic Disease;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;Cardiovascular system;Cessation of life;Chronic;Clinical Research;Clinical Trials;clinically relevant;Coronary;Data;Deposition;design;Development;endothelial dysfunction;Event;Fatty acid glycerol esters;Future;GLP-I receptor;Goals;Guidelines;Health;heart disease risk;Heart Diseases;high risk population;HIV;Image;Impairment;improved;Inflammation;inflammatory milieu;Intervention Studies;Knowledge;late life;life span;Link;Lipoproteins;Longitudinal Studies;Mediating;men;Metabolism;Myocardial Infarction;Nature;Nitric Oxide;novel;novel therapeutic intervention;Outcome;Participant;Pathway interactions;Patients;Persons;Population;Premature Menopause;Prevalence;prevent;programs;Proteomics;Public Health;Research;Risk;Risk Assessment;Risk Marker;Role;sex;Sex Differences;systemic inflammatory response;Testing;Time;Translating;Vascular Endothelium;Woman;women versus men;Women's Group;Women's mortality;Work

PROJECT_TITLE: Sex-specific factors, inflammation and vascular health across the lifespan in women living with HIV

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-L (O2)]


NIH_SPENDING_CATS: Contraception/Reproduction;Infectious Diseases;Maternal Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project narrative: Intrauterine inflammation is an important cause of preterm labor and injury to the brain, lung and GI tract of the unborn fetus and thus constitutes a major public health problem in this population. This grant will study the efficacy of R5020 in preventing preterm labor and intrauterine inflammation in Rhesus macaques. This knowledge will be important to develop treatment approaches aimed at improving maternal and child health.

PI_NAMEs: KALLAPUR, SUHAS  (contact);MESIANO, SAM ANTONIO

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: 37 weeks gestation;Address;Adverse effects;Affect;Affinity;Agonist;Amniotic Fluid;Animal Model;Animals;Anti-Inflammatory Agents;Antibiotics;astrogliosis;Biological;Birth;Brain;Brain region;Caproates;Cell Nucleus;cell type;Cells;cervicovaginal;Clinical;clinically relevant;Color;Country;Data;Decidua;Disease;Down-Regulation;drug repurposing;Drug Targeting;E. coli bacteremia;Effectiveness;effectiveness evaluation;efficacy evaluation;efficacy study;Enzymes;Escherichia coli;European;experimental study;Failure;fetal;fetal brain injury;Fetal Lung;Fetal Reduction;Fetus;Flow Cytometry;Future;Gastrointestinal tract structure;Gene Expression;Genes;Genomics;Goals;Grant;Gynecologic;Human;Human Pathology;Immune;Immune system;Immunology;improved;Incidence;Inflammation;Inflammatory;inflammatory marker;inflammatory milieu;Injections;Injury;intrauterine infection;intrauterine inflammation;Knowledge;knowledge base;Lavage;Link;Lipopolysaccharides;Lung;Macaca mulatta;Manufacturer;Marker Discovery;Marketing;Maternal and Child Health;Maternal-Fetal Exchange;Measures;Mediating;Menopause;Metabolism;Microglia;Modeling;Molecular;Morbidity - disease rate;multidisciplinary;Mus;myometrium;neonatal morbidity;Neonatal Mortality;neuroinflammation;Neurologic Effect;neuron development;Neurons;Neurosciences;Neutrophil Activation;Neutrophil Infiltration;nonhuman primate;novel;Nuclear;Oils;Organ;Oxidoreductase;Pathogenesis;Pathologic;Pathway interactions;Peripheral;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiological;Population;pre-clinical;Pregnancy;Pregnant Women;Premature Birth;Premature Labor;prenatal;preterm newborn;prevent;Prevention;Preventive therapy;Progesterone;Progesterone Receptors;Progestins;Property;Prophylactic treatment;Proteomics;Public Health;pup;receptor;Receptor Signaling;Recommendation;Research;Residual state;Resistance;Resolution;response;response to injury;Rhesus;RU-5020;Science;single nucleus RNA-sequencing;Stimulus;Stress;Supplementation;Synthetic Progestogens;systemic inflammatory response;Techniques;Testing;Therapeutic;therapeutically effective;Tissues;transcriptome sequencing;transcriptomics;translational approach;Uterus;Validation;Vulnerable Populations;Withdrawal;Woman

PROJECT_TITLE: Drug repurposing of a novel synthetic progestin for the prevention of preterm labor and fetal inflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (81)]


ADMINISTERING_IC: CE

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PI_NAMEs: SOKOL, REBECCAH LYN (contact)

PROJECT_TITLE: RFA-CE-22-005, Research Grants for Preventing Violence and Violence Related Injury (R01) - 2022


ORG_CITY: DAVIS

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Millions of patients who are prescribed opioids for chronic pain are co-prescribed benzodiazepines, and benzodiazepines increase the risk of overdose risk with long-term opioid use. This project will elucidate patients and prescribing factors associated with initiation of benzodiazepines in patients prescribed opioids, and among patients already co-prescribed opioids and benzodiazepines, factors associated with prescription or illicit drug overdose. Study findings will inform efforts to reduce national overdose prevention efforts targeting opioid and benzodiazepine prescribing.

PI_NAMEs: FENTON, JOSHUA J (contact);HENRY, STEPHEN G

PROJECT_TITLE: RFA-CE-22-011: Patterns and trajectories associated with overdose in patients co-prescribed opioids and benzodiazepines


ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PUBLIC HEALTH RELEVANCE STATEMENT This proposal research is relevant to public health because the identification of metabolic flux and regulatory mechanisms of polyamines, and glucose/ammonia metabolism in mosquitoes is expected to fill gaps in current understanding of how female mosquitoes maintain nitrogen and carbon metabolism, and regulate the proper disposition of nitrogen waste upon a blood meal without which ammonia levels could reach lethal concentrations. Thus, this proposed research is relevant to the part of the NIH´s mission that pertains to developing fundamental knowledge toward the identification of metabolic targets or regulators that can assist in the development and implementation of better mosquito control strategies to improve public health, economies, and leisure.

PI_NAMEs: SCARAFFIA, PATRICIA YOLANDA (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Aedes;Alanine Transaminase;Amino Acids;Ammonia;Arthropod Vectors;base;Biochemical;biological systems;Blood;Carbon;Cessation of life;Chemicals;Crystallization;Culicidae;Data;Deacetylase;Deacetylation;Deamination;Derivation procedure;design;Development;Diet;Digestion;Disease Vectors;Drug Metabolic Detoxication;egg;Enzymes;Excretory function;Fat Body;feeding;Female;flexibility;gene cloning;Genes;Genetic Techniques;Genetic Transcription;Glucose;glucose metabolism;Glutamine;Glycolysis;Goals;Heme;Immunoprecipitation;improved;Infection;inhibitor;innovation;Isotopes;Kinetics;Knowledge;Learning;Leisures;Life;Link;liquid chromatography mass spectrometry;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methods;Mission;Molecular;Monitor;Mosquito Control;Nitrogen;novel;Nutrient;Nutritional status;Ornithine Decarboxylase;Outcome;Pathway interactions;Phenotype;Polyamines;Production;protein purification;Proteins;Public Health;public health relevance;Pyruvate Kinase;Quality of life;Quantitative Reverse Transcriptase PCR;Recombinants;Refuse Disposal;Regulation;Reproduction;Research;Research Proposals;reverse genetics;RNA Interference;sample fixation;Sampling;Sirtuins;Stable Isotope Labeling;Structure;sucking;sugar;Techniques;Technology;Testing;Toxic effect;transmission process;United States National Institutes of Health;urea cycle;Uric Acid;wasting;Western Blotting;XDH gene

PROJECT_TITLE: Mechanistic regulation of ammonia metabolism in Aedes aegypti mosquitoes

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;HIV/AIDS;Infectious Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: NARRATIVE The Strategic Timing of Antiretroviral Treatment (START) is an international randomized trial designed to determine whether initiation of ART at CD4+ counts > 500 cells/mm3 (immediate or early ART) is superior in terms of morbidity and mortality to deferral of ART until the CD4+ declines to 350 cells/mm3 (deferred ART). With this proposal, investigators in the International Network for Strategic Initiatives in Global HIV Trials (INSIGHT) will continue follow-up of the 4,684 HIV-positive participants enrolled in START through December 2021 and carry out final data analyses in 2022 and 2023.

PI_NAMEs: GRUND, BIRGIT  (contact);REILLY, CAVAN S.;SHARMA, SHWETA

PROGRAM_OFFICER_NAME: PALMER, ROBERT C

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;antiretroviral therapy;Applications Grants;arm;Authorization documentation;Award;Bacterial Infections;Calendar;Cardiovascular Diseases;CD4 Lymphocyte Count;Cells;Characteristics;Cirrhosis;Clinical;Clinical Trials Data Monitoring Committees;Collection;Consent;cost efficient;Data;Data Analyses;Data Collection;End stage renal failure;Event;follow-up;Foundations;Funding;Future;Geography;Grant;HIV;HIV Seropositivity;International;International AIDS;International Network for Strategic Initiatives in Global HIV Trials;Journals;Longterm Follow-up;Malignant Neoplasms;Medicine;meetings;Morbidity - disease rate;mortality;National Institute of Allergy and Infectious Disease;New England;Outcome;Paper;Participant;participant enrollment;Persons;primary endpoint;Protocols documentation;Publishing;Randomized;randomized trial;Recommendation;Research Personnel;response;Risk;RNA;Societies;Subgroup;symposium;Time;trait;treatment group;treatment guidelines;Treatment Protocols;treatment trial;trial design;Tuberculosis;Viral;virus genetics;Work

PROJECT_TITLE: Extended follow-up of randomized participants in the INSIGHT START trial


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Social Determinants of Health

ORG_CITY: SAN DIEGO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: San Diego State University (SDSU) is applying for a competitive renewal to continue its successful (92% of the scholars have entered graduate programs in the field of aging) National Institute of Aging MSTEM: Advancing Diversity in Aging Research (ADAR) through Undergraduate Education program. The SDSU ADAR program has been effective in increasing the number of highly qualified individuals from diverse backgrounds, including underrepresented racial and ethnic minorities, people with disabilities, and disadvantaged students, and those groups underrepresented in the biomedical and behavioral sciences, to pursue further studies or careers in research; specifically, Ph.D. programs focused on aging research. In the past 3 years, four cohorts of SDSU ADAR scholars have graduated, and are pursuing their graduate degrees at universities with well regarded research programs.

PI_NAMEs: CRONAN, THEREASA A (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: academic program;Affect;aged;Aging;aging population;Alzheimer's Disease;Bachelor's Degree;Behavioral Sciences;California;career;Cognitive aging;cohort;Collaborations;Communities;cultural competence;Dedications;design;Development;Disabled Persons;disabled students;Disadvantaged;disadvantaged student;disease disparity;Disparity;Doctor of Philosophy;Education;Educational Curriculum;Eligibility Determination;Ensure;Esapent;ethnic minority;Event;experience;Extramural Activities;Faculty;faculty mentor;Foundations;Funding;Future;Goals;Graduate Degree;Grant;hands on research;Health Disparities Research;health disparity;Hispanic-serving Institution;Home;Individual;innovation;Institution;interest;Intervention;Joints;Knowledge;Laboratories;Laboratory Research;Learning;matriculation;medical schools;Mentors;Mentorship;minority student;National Institute on Aging;NIH Program Announcements;notch protein;Population Heterogeneity;Positioning Attribute;Probability;programs;promote resilience;Qualifying;racial minority;Recording of previous events;recruit;Research;Research Activity;Research Personnel;resilience;responsible research conduct;Science;Scientist;Series;skills;social;Structure;student participation;Students;success;summer research;supportive environment;Training;Training Programs;undergraduate education;undergraduate student;Underrepresented Populations;Underrepresented Students;United States;United States National Institutes of Health;Universities;Visit;Work

PROJECT_TITLE: SDSU ADAR Program