ORG_CITY: KNOXVILLE

ORG_NAME: UNIVERSITY OF TENNESSEE KNOXVILLE

ORG_STATE: TN

PHR: PROJECT NARRATIVE The dynamic nature of G protein-coupled receptors (GPCRs) enables these sensory proteins to recognize and bind a wide range of extracellular molecules with different shapes and chemical properties. We plan to directly visualize the dynamic behavior of GPCRs in real-time using single-molecule fluorescence microscopy, which reveals hidden structural characteristics that should provide new insights into GPCR functions in native-like environments. We initially apply this state-of-the-art microscopy technique to investigate the dynamic behavior of two human GPCRs: an adenosine receptor that regulates inflammation and a glucagon receptor that binds the main metabolic hormone in the human body.

PI_NAMEs: LAMICHHANE, RAJAN  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: ADORA2A gene;Affect;Behavior;Benchmarking;Binding;blood glucose regulation;Characteristics;chemical property;Chemical Structure;Complex;conformer;Cryoelectron Microscopy;design;diabetes mellitus therapy;Disease;Drug Targeting;Environment;extracellular;Extracellular Domain;FDA approved;Fluorescence;Fluorescence Microscopy;G-Protein-Coupled Receptors;Glucagon;Glucagon Receptor;Glucagon Receptor Binding;Goals;Hormones;Human;Human body;improved;Inflammation;insight;Investigation;Ligand Binding;Ligands;Lipids;Maps;Measurement;Membrane;Membrane Proteins;Metabolic hormone;Microscopy;Molecular Conformation;Mutation;Nature;Neurotransmitters;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutics;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Proteins;Purinergic P1 Receptors;Receptor Activation;receptor function;Research Project Grants;response;Role;screening;Sensory;Sensory Receptors;Shapes;Signal Transduction;Signaling Protein;single molecule;small molecule;Structure;Techniques;Therapeutic;Time;time use;Transmembrane Domain;Visualization;X-Ray Crystallography

PROJECT_TITLE: Conformational Dynamics of G Protein-Coupled Receptors at the Single-Molecule Level


ADMINISTERING_IC: FD

ARRA_FUNDED: N

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: LEXINGTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MISCELLANEOUS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative Reference cigar tobacco products are a necessary tool for measuring and reporting harmful and potentially harmful constituents in tobacco products as required under the Family Smoking Prevention and Tobacco Control Act. Three new, machine-made, sheet-wrapped, certified cigar reference products representative of large cigars (processed leaf filler, non-premium), little cigars (brown cigarettes) and small cigars (cigarillos) will be manufactured in one manufacturing run each to ensure product uniformity, and will have certified characteristics to allow for a proficiency testing program, instrument calibration, employee/student training, method validation and for investigational purposes. The University of Kentucky Center for Tobacco Reference Products (CTRP) will expand our program for tobacco analysis and reference tobacco products to support collaborative studies, improved constituent analysis, storage and stability research and the manufacture and distribution of cigar tobacco reference products with significant proposed improvements and development in all of these areas.

PI_NAMEs: CHAMBERS, ORLANDO  (contact)

PROGRAM_OFFICER_NAME: WAKEFIELD, CHRISTI

PROJECT_TITLE: Cigar Reference Products Program


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Complementary and Integrative Health;Digestive Diseases;Infant Mortality;Microbiome;Neurosciences;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: NARRATIVE Neurodevelopmental impairment (NI) is a significant sequala in survivors of the neonate disease necrotizing enterocolitis (NEC). Neuroinflammation is a key factor in the development of NI, and we have developed a novel therapeutic probiotic that protects the intestines from experimental NEC and attenuates the inflammatory responses that can affect long term neurodevelopment. In this project, we take advantage of our novel platform that enables beneficial probiotic activities to be tuned, and thus enhanced, for specific benefits as we aim to identify, prevent, and treat neuroinflammatory responses capable of driving NI related to NEC.

PI_NAMEs: BAILEY, MICHAEL T (contact);BESNER, GAIL E;GOODMAN, STEVEN D

PROGRAM_OFFICER_NAME: PILEGGI, ANTONELLO

PROJECT_TERMS: Adherence;adverse event risk;Affect;Anti-Inflammatory Agents;Antiinflammatory Effect;antimicrobial;Attenuated;attenuation;Automobile Driving;Bacteria;Bacterial Translocation;behavioral outcome;Biological;Biological Sciences;biomaterial compatibility;Birth;Brain;Brain Injuries;Cessation of life;Clinical Research;Clinical Trials;Complex;Coupled;Data;Development;Disease;Dose;dysbiosis;early life stress;experimental study;Exposure to;FDA approved;feeding;Formulation;Future;Glycerol;Goals;gut inflammation;gut microbes;H2 gene;Histamine;Histidine;Hypoxia;improved;Incidence;Indoles;Infection;Inflammation;Inflammatory Response;Intestines;Lead;Life;Link;Microbial Biofilms;microbiome;microbiota;Microspheres;Modeling;Multiple Organ Failure;natural hypothermia;Necrosis;Necrotizing Enterocolitis;Neonatal;neonate;neurodevelopment;Neurodevelopmental Impairment;neuroinflammation;novel;novel therapeutic intervention;novel therapeutics;Pathway interactions;pediatric pharmacology;Phase I Clinical Trials;Porosity;Predisposition;preempt;Pregnancy;premature;Premature Infant;prevent;Prevention;probiotic therapy;Probiotics;Production;Property;protective effect;pup;Rattus;Regimen;Research;resilience;response;Risk;Role;Sepsis;Surface;Survivors;System;Testing;Therapeutic;Time;Translational Research;Tryptophan;Tryptophan Metabolism Pathway

PROJECT_TITLE: A novel live biologic for the prevention and treatment of NEC-induced neurodevelopmental impairment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (81)]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Kidney Disease;Pediatric;Rare Diseases

ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will advance knowledge of the pathogenesis of Alport syndrome, a hereditary disease that leads to end stage kidney disease in affected individuals. The disease is caused by mutations in the type IV collagen genes encoding 3, 4 and 5 chains, which reside in the glomerular basement membrane. Although their role in glomeruli is well-studied, the role of these collagen chains in kidney tubules is largely unknown. Here we will examine the contribution(s) of tubular cells to the clinical signs, pathogenesis, and progression of this disease.

PI_NAMEs: MARCIANO, DENISE K (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Abnormal Cell;Affect;Albuminuria;Alleles;Apoptosis;Architecture;Basement membrane;Bioinformatics;Cell Physiology;Cell Shape;cell type;Cells;Chronic Kidney Failure;Clinical;Collagen;Collagen Gene;Collagen Type IV;Data;Defect;Deposition;Development;Disease;Disease Progression;Duct (organ) structure;Electrolytes;End stage renal failure;endoplasmic reticulum stress;Engineering;Exhibits;Fibrosis;Functional disorder;Future;Gene Expression;Genetic;glomerular basement membrane;Hematuria;Henle's loop;Hereditary Disease;Hereditary nephritis;Human;Immunofluorescence Immunologic;Impairment;Individual;Inherited;Injury;Kidney;Kidney Concentrating Ability;Kidney Diseases;Knowledge;Light;Limb structure;Link;male;Microscopy;Modeling;Morphology;Mus;Mutation;Normal Cell;novel;novel therapeutic intervention;Onset of illness;Organ;Pathogenesis;Pathogenicity;Patients;Phenotype;Play;podocyte;Process;Proteinuria;Public Health;Rattus;receptor;Renal function;Renal glomerular disease;Renal tubule structure;Reporting;Research;Research Design;Resolution;Resources;Role;Shapes;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;Sodium Chloride;stem;Structural defect;Structure;Thick;Thinness;tool;Toxic effect;Tubular formation;urinary;Variant;Water

PROJECT_TITLE: Elucidating novel mechanisms in the pathogenesis of Alport syndrome

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza

ORG_CITY: ITHACA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative We propose to develop a novel, cost-effective, and highly flexible therapeutic platform to treat a range of respiratory viruses. We will use an innovative design approach, based on targeting host cell proteases, and test both the therapeutic and prophylactic response and protective response in a mouse and ferret models. Due to the conserved nature of the target, we anticipate that our approach will be applicable to and effective across a wide range of existing and emerging viruses.

PI_NAMEs: AGUILAR-CARRENO, HECTOR ;WHITTAKER, GARY R (contact)

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 2019-nCoV;airway epithelium;Animal Model;Anti-viral resistance;Biochemical;Biological;Biological Assay;Cell Culture System;Cell Culture Techniques;Cell membrane;Cells;Cellular biology;Coronavirus;Coronavirus Infections;cost effective;COVID-19 therapeutics;Data;design;Disease;Docking;drug development;Drug Targeting;Drug usage;Effectiveness;emerging virus;Ferrets;flexibility;Goals;Human;human coronavirus;Human Metapneumovirus;improved;in vivo;Infection;Infectious Agent;Influenza;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H2N2 Subtype;Influenza A Virus, H3N2 Subtype;Influenza A Virus, H7N9 Subtype;Influenza Hemagglutinin;influenza infection;influenzavirus;inhibitor;innovation;interest;Laboratories;Lead;lead candidate;Libraries;Mediating;Membrane;Mesocricetus auratus;Middle East Respiratory Syndrome Coronavirus;Modeling;mouse model;Mus;Nature;novel;novel coronavirus;novel therapeutics;novel virus;Para-Influenza Virus Type 1;Paramyxovirus;Peptide Hydrolases;Peptide Synthesis;Peptides;peptidomimetics;Pneumovirus;prevent;Process;Production;prophylactic;Protease Inhibitor;Proteins;Public Health;respiratory;Respiratory Tract Infections;respiratory virus;response;Role;SARS-CoV-2 infection;SARS-CoV-2 variant;seasonal coronavirus;Seasons;Serine Protease;Site;small molecule;Specificity;System;Testing;Therapeutic;therapeutic target;TMPRSS2 gene;transmission process;Trypsin;Viral;viral transmission;virology;Virus;Virus Replication;Work

PROJECT_TITLE: Developing broad-based treatments for respiratory viruses by targeting host cell TTSPs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-B(81)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: STILLWATER

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: OKLAHOMA STATE UNIVERSITY STILLWATER

ORG_STATE: OK

PHR: Project Narrative - OADDL Testing Support for CVM Vet-LIRN Oklahoma Animal Disease Diagnostic Laboratory (OADDL) will offer its expertise and services to participate in critical disease testing and surveillance projects initiated by the Food and Drug Administration (FDA), Center for Veterinary Medicine (CVM) Office of Research Veterinary Laboratory Investigation and Response Network (Vet-LIRN). OADDL will provide testing support and expertise in foodborne and other disease investigations, disease surveillance studies, pathogen characterization, and test methods development. These efforts will help strengthen Vet-LIRN’s response capabilities especially in the event of disease outbreaks and implement appropriate control measures to protect public and animal health.

PI_NAMEs: RAMACHANDRAN, AKHILESH  (contact)

PROGRAM_OFFICER_NAME: CERIC, OLGICA

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CVM-K (01)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cancer;Chronic Pain;Clinical Research;Dental, Oral, and Craniofacial Disease;Depression;Digestive Diseases;Mental Health;Neurosciences;Pain Research;Palliative Care;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Head and neck cancer patients experience severe pain and stress. The proposed studies investigate how sympathetic and sensory nerves interact to drive cancer pain and promote cancer growth. This approach has the potential for new therapeutic strategies to treat cancer progression and pain by targeting neurons.

PI_NAMEs: SCHEFF, NICOLE N (contact)

PROGRAM_OFFICER_NAME: GHIM, MELISSA M

PROJECT_TERMS: Address;Adrenergic Agents;Adrenergic Antagonists;Adrenergic beta-Antagonists;Adrenergic Receptor;afferent nerve;Afferent Neurons;Aftercare;Animal Model;antagonist;Anxiety;Behavior;Behavioral;Benign;beta-adrenergic receptor;Biological;Breast;Calcium;cancer cell;cancer diagnosis;cancer invasiveness;cancer pain;Cancer Patient;carcinogenesis;Catecholamines;Cell Proliferation;Cells;chemical carcinogen;chronic pain;Chronic stress;Clinical;Clinical Trials;Combined Modality Therapy;Data;Disease Progression;Dose;drinking water;Electrophysiology (science);emotional experience;experience;gastrointestinal;Goals;Growth;Growth and Development function;Head and Neck Cancer;head and neck cancer patient;Head and Neck Squamous Cell Carcinoma;improved outcome;In Vitro;in vivo;Incidence;Inflammation;Injury;Long-Term Effects;malignant mouth neoplasm;Malignant Neoplasms;Measures;Mediating;Mediator;Mental Depression;Metastatic Neoplasm to Lymph Nodes;Microscopy;mouse model;Mus;Nerve;nerve supply;Neurons;Neuropeptides;neurotransmission;Nociception;Norepinephrine;novel therapeutic intervention;Optics;Oral;Oral cavity;oral lesion;orofacial;Pain;pain behavior;Pain management;pain symptom;palliation;Patient Outcomes Assessments;Patients;Peripheral;Peripheral Nerves;Phase;Physiological;Plasma;pre-clinical;Pre-Clinical Model;Predisposition;prognostic;prognostic indicator;Propranolol;prospective;Prostate;Psychological Impact;Psychological Stress;psychological symptom;psychosocial;Psychosocial Stress;Quality of life;receptor expression;receptor function;Receptor Signaling;Reporting;Resolution;Risk Factors;Signal Transduction;Social support;Stains;Stress;Survivors;survivorship;Sympathectomy;Sympathetic Nervous System;Symptom Burden;Testing;Therapeutic;Tongue;Treatment Protocols;Treatment-Related Cancer;Trigeminal System;tumor;tumor microenvironment;tumor progression;tumorigenesis;Visualization;Xenograft procedure

PROJECT_TITLE: Sympathetic modulation of head and neck cancer pain

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_CITY: CHESTNUT HILL

ORG_NAME: BOSTON COLLEGE

ORG_STATE: MA

PHR: PROJECT NARRATIVE The capsids of lentiviruses (family Retroviridae) are involved in multiple, post-entry interactions with host factors, including both host-dependency factors and antiviral (restriction) factors. In this project, we seek to understand the dynamic evolutionary interplay between lentivirus capsids, the major nuclear pore component Nup358, and the capsid-targeting restriction factor TRIM5. To achieve the project goals, we use a comparative approach encompassing the human viruses HIV-1 and HIV-2, and the related simian immunodeficiency viruses of old world primates.

PI_NAMEs: JOHNSON, WELKIN E (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Active Biological Transport;Affect;Alleles;Animal Model;Binding;Biological;Biology;Bypass;C-terminal;Capsid;Capsid Proteins;Cell Culture Techniques;Cell division;Cells;Cercocebus atys;cofactor;comparative;Complement;Complex;Cyclophilin A;Cyclophilins;Cytoplasm;Data;Dependence;Detection;DNA;Docking;Elements;Encapsulated;Enzymes;Evolution;Family;Filament;Genes;Goals;HIV;HIV-1;HIV-2;HIV/AIDS;Homologous Gene;Human;Immune;Infection;Innate Immune Response;innovation;Integration Host Factors;integration site;Interferons;Interphase Cell;knock-down;Knock-out;Lentivirus;Literature;Macaca;Macaca mulatta;Macrophage;Mitotic;Modeling;Molecular;Monkeys;new therapeutic target;nonhuman primate;Nuclear;Nuclear Envelope;Nuclear Import;Nuclear Pore;Nuclear Pore Complex;nucleocytoplasmic transport;Pathogenicity;Pathway interactions;pre-clinical;Primate Lentiviruses;Primates;Property;Proteins;Publications;Publishing;Reporting;Research;response;Rest;Retroviridae;Rhesus;Role;sensor;simian human immunodeficiency virus;SIV;Specificity;T-Lymphocyte;Tissues;TRIM5 gene;Variant;Viral;Viral Genome;Viral Reverse Transcription;Virion;Virus;virus host interaction;Virus Replication;Work

PROJECT_TITLE: Replication and Evolution of Primate Lentiviruses

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative: My group develops biosensor tools that enable the visualization of enzymatic processes inside living cells as they move. This is an important area of study in basic biology because it increases understanding about mechanisms that differentiate normal cells (e.g., immune cells) from diseased cells (e.g., tumor cells) as they move and migrate throughout the human body. I will develop molecular imaging tools that enable the simultaneous recording of two different enzymatic protein activities in living cells, which will then allow me to decode the coordination of multiple signaling proteins that regulates cell movement.

PI_NAMEs: HODGSON, LOUIS  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Area;Biology;Biosensor;cell motility;Cells;Cellular biology;chemokine;Chemotaxis;Data;design;Development;Disease;Fibroblasts;Fluorescence Resonance Energy Transfer;Guanosine Triphosphate Phosphohydrolases;Health;Human;Human body;imaging approach;Imaging Device;Immune;Inflammatory;Invaded;Macrophage;Malignant Breast Neoplasm;migration;Modality;Molecular;molecular imaging;monomer;Motility;multiplexed imaging;Neoplasm Metastasis;neoplastic cell;Normal Cell;novel;optogenetics;Pathway interactions;Process;Proteins;response;rho GTP-Binding Proteins;Role;Signal Pathway;Signal Transduction;Signaling Protein;System;Techniques;Technology;temporal measurement;Time;tool;tumor;Visualization

PROJECT_TITLE: Multiplex Imaging of Signaling Pathways in Cell Motility


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: BIRMINGHAM

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE The UAB Blazer BRAIN (Broadening Representation And Inclusion in Neuroscience) Summer Program at the University of Alabama at Birmingham (UAB) focuses on increasing diversity in the neuroscience workforce through providing an outstanding summer research and educational experience for undergraduates earning their STEM degree at partner HBCUs and throughout the southeast U.S. This experience will instill confidence and excitement in these talented students and increase their desire for a career as a neuroscience researcher.

PI_NAMEs: GAVIN, CRISTIN F;SHACKA, JOHN J (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Advisory Committees;Alabama;Biomedical Research;career;career life balance;Communication;design;Development;Diverse Workforce;Doctor of Philosophy;Doctor's Degree;Education;Environment;Evaluation;experience;Exposure to;faculty mentor;Funding;Future;Goals;graduate school;Historically Black Colleges and Universities;improved;Institution;Investments;Laboratories;Learning;medical schools;meetings;Mentors;Minority Groups;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurosciences;Neurosciences Research;programs;recruit;Research;research faculty;Research Personnel;Scholars Program;Science;Scientist;Secure;skills;Southeastern United States;Students;success;summer program;summer research;symposium;Talents;undergraduate student;Underrepresented Minority;United States;United States National Institutes of Health;Universities


ADMINISTERING_IC: DP

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: Project Narrative Glaucoma is the second leading cause of blindness in the United States, with over half of those with glaucoma unaware that they have it, especially underserved minority populations. We will screen for glaucoma using innovative autonomous AI-grading of retinal photographs already being obtained to identify diabetic eye disease in community clinics serving at-risk populations. The project will track the outcomes of these individuals and compare these to those of individuals undergoing diabetic eye disease screening who are not being screened for glaucoma to determine the costs and benefits of the program.

PI_NAMEs: FRIEDMAN, DAVID S (contact)

PROGRAM_OFFICER_NAME: SANDERS, CELESTE

PROJECT_TITLE: DP24-081 The Glaucoma and Retinopathy Screening Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZDP1 OHI (02)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Anxiety Disorders;Brain Disorders;Mental Health;Natural Products;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: DAVIS

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Project Narrative. The proposed research is relevant to public health because the development of novel chemistry to synthesize small molecules with new core structures is critical to the discovery of new leads for drug discovery. As such, the experiments described in this proposal are relevant to the NIH’s mission because they will enable the discovery of previously inaccessible molecules with the potential to become new medicines that will "enhance health, lengthen life, and reduce illness and disability."

PI_NAMEs: SHAW, JARED THOMAS (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Acute Disease;Address;Alkaloids;Architecture;Area;carbene;catalyst;Chemicals;Chemistry;Chronic Disease;Complex;Custom;cycloaddition;design;Development;diene;disability;drug discovery;experimental study;Goals;Health;innovation;Legal patent;Life;Medicine;Mental Depression;Metals;Methodology;Methods;Mission;Modeling;molecular assembly/self assembly;Natural Products;Nervous System Disorder;Neuronal Plasticity;next generation;novel;novel therapeutics;Organic Chemistry;parent grant;Pharmacologic Substance;Post-Traumatic Stress Disorders;Process;programs;Public Health;Reaction;Research;Rhodium;small molecule;Societies;Structure;Time;Translating;United States National Institutes of Health

PROJECT_TITLE: Supplement: Studies in the Synthesis of Complex Organic Molecules with Donor-Donor Carbenes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


NIH_SPENDING_CATS: Bioengineering;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Nutrition;Regenerative Medicine

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Narrative Metabolic dysfunction-associated steatotic liver disease (MASLD) is common among the elderly as, with age, the liver undergoes substantial changes in function and structure that are associated with impairment of the liver’s normal functioning and operations (e.g., detoxification and metabolic activities). Ample data demonstrate that, in MASLD, impaired lysosomal acidification results in loss of autophagic flux and accumulation of lipid/fatty acids within the liver. We propose novel acid-activated, treatment called LysoGen, with tunable acidification capability, as a treatment for high-fat diet (HFD)-induced MASLD wherein the LysoGen polymer regenerates lysosomal acidity, restores autophagic flux and reverses the functional and histological hallmarks of MASLD.

PI_NAMEs: GRINSTAFF, MARK W. (contact);SHIRIHAI, ORIAN S;SINGH, RAJAT

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Acidity;Acids;Address;Affect;Age;age-related disease;Agonist;Autophagocytosis;Autophagosome;Biocompatible Materials;Biodistribution;Biological Availability;Biology;biomaterial compatibility;Butylene Glycols;Cell Maintenance;Cell Physiology;Cells;Cellular Metabolic Process;Charge;Cirrhosis;clinical translation;Collaborations;copolymer;Data;design;dietary;Disease;disease model;Disease Progression;dosage;Dose;Drug Metabolic Detoxication;Eating;Elderly;Engineering;Ensure;Esterified Fatty Acids;ethylene glycol;Evaluation;Experimental Designs;Exposure to;Failure;Fatty Acids;Fatty Liver;Formulation;Functional disorder;Future;GLP-I receptor;Glucose;Glycolates;Hepatic;Hepatocyte;HepG2;High Fat Diet;Histologic;Human;Hydrolysis;Hydrophobicity;Impairment;improved;In Vitro;in vivo;Incidence;insight;Insulin Resistance;insulin sensitivity;Intervention;intravenous administration;Label;Lactic acid;late endosome;Libraries;Lipids;Liver;Liver diseases;Liver Failure;Lysosomal Function Inhibition;lysosome membrane;Lysosomes;Measures;Mediating;Membrane Lipids;Metabolic;Metabolic dysfunction;middle age;Mitochondria;Modeling;Molecular Weight;mouse model;Mus;Natural regeneration;new technology;Nomenclature;non-alcoholic fatty liver disease;Nonesterified Fatty Acids;Normal Range;novel;Obesity;operation;Organelles;Palmitates;particle;Particle Size;Pathology;Pathway interactions;pharmacologic;Polyesters;Polymer Chemistry;Polymers;Prevalence;Primary carcinoma of the liver cells;Process;Property;Proteins;proteostasis loss;Regimen;response;restoration;rho;Rhodamine;Risk Factors;Safety;Saturated Fatty Acids;Steatohepatitis;Structure;Succinic Acids;Therapeutic;Toxic effect;Triglycerides;uptake;vacuolar H+-ATPase;Variant;Work

PROJECT_TITLE: Lysosomal Regeneration (LysoGen) and Rescue as a Treatment for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

STUDY_SECTION: INN

STUDY_SECTION_NAME: Innovations in Nanosystems and Nanotechnology Study Section [INN]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative The Community Health Information and Education Forum (CHIEF), a collaboration between Mount Sinai researchers and the Arthur Ashe Institute for Urban Health, aims to combat health misinformation and promote equitable health in marginalized communities. Leveraging community-based networks, CHIEF will develop a technology platform to enable community influencers to disseminate accurate, tailored health information. This initiative, which involves students in the creation of health messages, is expected to have a measurable impact in promoting equitable health in at-risk communities.

PI_NAMEs: CLAUDIO, LUZ  (contact)

PROGRAM_OFFICER_NAME: GILLMAN, ARIELLE SAMANTHA

PROJECT_TERMS: Academy;Active Learning;Address;African American;African Caribbean;Artificial Intelligence;Barbering;Beauty;career;Client;Collaborations;Color;combat;Communities;community based participatory research;Community Health;Community Health Planning;community organizations;community partners;community planning;dashboard;Data;design;Development;Disparity population;distrust;diversity and inclusion;Education;Educational Measurement;Ensure;Epidemic;equity, diversity, and inclusion;experience;Exposure to;Face;Faculty;Funding;Geographic Locations;Goals;Government;Grant;Health;health communication;health disparity;Health education;health equity;health equity promotion;health literacy;Health Occupations;Health Promotion;Health Sciences;High School Student;implementation evaluation;implementation science;improved;Information Dissemination;innovation;Intervention;Life;Maps;marginalized community;marginalized population;Measurable;Measures;medical schools;member;Mentorship;mHealth;minority communities;Misinformation;mobile application;Modeling;Names;New York;New York City;Outcome;pandemic disease;Population;population health;Population Heterogeneity;prevent;programs;Public Health;public health research;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reduce health disparities;Research;Research Personnel;Research Project Grants;Research Training;Resources;response;Risk;Role;Running;Science;smartphone application;social media;sound;student participation;Students;Technology;technology platform;Time;tool;Training;Training Programs;Trust;trustworthiness;Underrepresented Minority;underserved minority;Underserved Population;United States National Institutes of Health;Urban Health

PROJECT_TITLE: Community Health Information Education Forum (CHIEF)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-H (90)]


ADMINISTERING_IC: HS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Project Narrative Excessive burnout and burden are complex and increasing problems affecting nearly all healthcare workers (physicians, nurses, staff) with significant consequences on provider well-being, patient safety, and care qual- ity, especially in primary care and under-resourced community health settings serving challenging patient pop- ulations. While the broad adoption of asynchronous care technology (patient portals, EHR email, text messag- ing) can significantly improve care and patient experience, it also contributes significantly to time stresses, work-after-work, and burnout – further exacerbated by (and contributing to) staff shortages, inefficient pro- cesses, and non-resilient systems. This project integrates systems science, engineering, and health service research methods, as recommended by National Academy of Medicine and US Surgeon General burnout re- ports, to better understand and address the relative impacts, etiology, effective strategies, and dynamics of these interrelated issues on caregiver burnout and patient safety.

PI_NAMEs: BENNEYAN, JAMES C (contact)

PROGRAM_OFFICER_NAME: RODRICK, DAVID

PROJECT_TITLE: Understanding and Addressing Community Health Center Burden, Resiliency, and Burnout - Systems Engineering Analyses and Approaches

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Type 2 diabetes (T2D) is among the most common chronic diseases worldwide, with prevalence growing in parallel with the obesity epidemic. In order to treat T2D more effectively, it is necessary to more fully understand how metabolic health breaks down in obesity. The work proposed in this application will study how reactivation of the Notch signaling pathway in the liver contributes to insulin resistance, a hallmark of T2D that is a major driver of the difficult-to- control high blood sugars that are characteristic of the disease.

PI_NAMEs: PAJVANI, UTPAL  (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Applications Grants;Beta Cell;Blood Glucose;Characteristics;Chronic Disease;Data;Development;Diet;Disease;Genetic Epistasis;Glucose Intolerance;Health;healthspan;Hepatic;Hepatocyte;Hyperglycemia;Immunoprecipitation;Impairment;In Vitro;Insulin Resistance;Laboratories;life span;Liver;Mass Spectrum Analysis;Mediating;Metabolic;Metabolic Diseases;Metabolic dysfunction;Modeling;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;notch protein;Notch Signaling Pathway;notch-2 protein;Obesity;Obesity Epidemic;obesogenic;Organogenesis;overexpression;Pathway interactions;Population;Prevalence;Production;receptor;Regulation;Research;Role;Signal Transduction;Structure of beta Cell of islet;Tissues;transmission process;Western Blotting;Work

PROJECT_TITLE: Dissecting the role of hepatocyte Notch receptors in obesity-driven metabolic disease.

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Fragile X Syndrome;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: WINSTON-SALEM

ORG_DEPT: PEDIATRICS

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narrative The proposed research will be the largest population-level study of health characteristics of individuals with fragile X syndrome from diverse racial and ethnic patient groups. This study offers an opportunity to 1) evaluate the rate of underdiagnosis across different racial and ethnic groups and quantify the gap between professional recommendations and clinical practice; 2) characterize lifetime clinical risk associated with this FXS; 3) assess the impact of access to specialty care; 4) develop novel pre-screening approaches that could be used to assist physicians in referring potential patients for FXS testing, which will reduce the duration and associated stress of the “diagnostic odyssey” for patients and families.

PI_NAMEs: MOVAGHAR, AREZOO  (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Acceleration;Age;Area;Artificial Intelligence;autism spectrum disorder;biomedical informatics;Biometry;Birth;burden of illness;Caring;case-based;Characteristics;Chicago;Clinic;Clinical;Clinical Data;clinical diagnosis;clinical practice;Clinical Research;clinical risk;Code;Complex;Data;Development;developmental psychology;Diagnosis;Diagnostic;Disease;Electronic Health Record;Epidemiology;ethnic diversity;Ethnic Origin;Ethnic Population;experience;Face;Family;Female;Fragile X Syndrome;Frequencies;General Population;Genetic;genetic disorder diagnosis;genetic testing;Goals;Guidelines;Health;health care service utilization;health disparity;Health system;Healthcare Systems;Heterogeneity;Hispanic;improved;Individual;Inherited;innovation;insight;Institution;Intellectual functioning disability;Investigation;Knowledge;Letters;Link;Machine Learning;male;Medical;Medical History;medical specialties;Meta-Analysis;metropolitan;Modeling;multidisciplinary;Not Hispanic or Latino;novel;novel strategies;Outcomes Research;Patient advocacy;patient population;patient subsets;Patient-Focused Outcomes;Patients;Pattern;Pediatrics;Penetrance;Personal Satisfaction;Phenotype;Physicians;Population;Population Study;predictive modeling;Prevalence;public health priorities;Race;racial diversity;racial population;Recommendation;Research;ROC Curve;Sampling;Scientist;screening;Screening procedure;sex;Site;Social Sciences;Source;Stress;Subgroup;success;Symptoms;Techniques;Testing;Time;tool;Translational Research;Universities;Variant;Wisconsin

PROJECT_TITLE: Health Disparities of Patients with Fragile X from Diverse Racial & Ethnic Groups

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE

PHR: Project Narrative Natural Killer (NK) cell-mediated antibody dependent cellular cytotoxicity (ADCC) is correlated with delayed progression of HIV disease, but exactly how antibodies regulate ADCC activity through immune complexes is not well-understood. This project will illuminate how the molecular nature of antibody binding to HIV influences NK cell ADCC activity by utilizing cutting-edge fluorescence microscopy to examine antibody receptors at the synapse between NK cells and their targets. The data from this project will form guiding principles to engineer HIV antibody therapeutics and vaccines aimed at eliciting more potent ADCC activity, with potential long-term applications to other human viruses and diseases.

PI_NAMEs: MURIN, CHARLES DANIEL (contact)

PROGRAM_OFFICER_NAME: SHANKAR, UDAY K

PROJECT_TERMS: 3-Dimensional;Affect;Antibodies;antibody engineering;antibody-dependent cell cytotoxicity;Antigen-Antibody Complex;arm;Binding;biophysical properties;Biophysics;Cells;Complement;Data;design;Disease;Engineering;Epitopes;Fc Receptor;FCGR3A gene;Fluorescence Microscopy;Fluorescence Resonance Energy Transfer;Geometry;Goals;Health;HIV;HIV Antibodies;HIV envelope protein;HIV Receptors;Human;human disease;IgG Receptors;immunological synapse;improved;In Vitro;in vivo;innovation;insight;Knowledge;Measurement;Measures;Mediating;Microscopy;millisecond;Molecular;molecular mechanics;nanoscale;Nanoscopy;Natural Killer Cells;Nature;novel strategies;Outcome;pathogenic virus;Pharmaceutical Preparations;Phosphotransferases;recruit;Resolution;Signal Transduction;single molecule;spatiotemporal;Synapses;Techniques;Testing;Therapeutic;Therapeutic antibodies;ultra high resolution;Vaccines;Virus;Work

PROJECT_TITLE: HIV antibodies and NK cell ADCC: nanometer-scale tracking of immune synapse dynamics.

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Cerebrovascular;Climate-Related Exposures and Conditions;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Rare Diseases;Vector-Borne Diseases

ORG_CITY: LONDON

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY OF WESTERN ONTARIO

ORG_STATE: ON

ORG_ZIPCODE: N6A 3K7

PHR: RELEVANCE In 2019, EEEV exhibited an unprecedented outbreak in the United States resulting in 38 confirmed cases and 15 deaths, as opposed to a recent average of 5-8 cases and 1-3 deaths. The outbreak occurred throughout the EEEV-endemic areas of the US (northern tier of eastern states, New England, south eastern seaboard and gulf coast) suggesting a nation-wide increase in virus activity (www.cdc.gov/easternequineencephalitis). Considering the virulence of EEEV, this raises significant concerns regarding the future incidence of EEEV disease, which may be impacted by climate change, mosquito vector and reservoir abundance, and human activity. In contrast with EEEV, Venezuelan equine encephalitis virus (VEEV), a related member of Alphaviruses, causes a much less severe disease in humans and 0.5-1% mortality in symptomatic cases. VEEV is endemic along the gulf coast of the US and also Latin and South America. Reflecting the human virulence of EEEV and potential biowarfare/bioterrorism uses of both viruses, they have been placed on the National Select Agent Registry and the viruses are considered Category B Priority Pathogens by the National Institutes of Health.

PI_NAMEs: KLEIN, ROBYN S. (contact);KLIMSTRA, WILLIAM B

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: 3' Untranslated Regions;adaptive immune response;Alpha Virus;Alphavirus Infections;Area;Astrocytes;Binding;Binding Sites;Biological Warfare;Bioterrorism;Blood - brain barrier anatomy;blood-brain barrier crossing;blood-brain barrier disruption;Brain;brain cell;brain endothelial cell;Brain imaging;Category B pathogen;Caveolins;cell type;Cells;Central Nervous System;Cessation of life;climate change;climate impact;Communication;cytokine;Dendritic Cells;Disease;Disease Outbreaks;Eastern Equine Encephalomyelitis;Encephalitis;Exhibits;experimental study;Future;genomic locus;gulf coast;Hematogenous;Hematopoietic;Heparitin Sulfate;Heterogeneity;Human;Human Activities;human model;IFNAR1 gene;Imaging Techniques;Immune;Immunoelectron Microscopy;In Vitro;in vivo;Incidence;Infection;Injury;Innate Immune Response;Integration Host Factors;Interferon Type I;Interferons;Intranasal Administration;Invaded;Latin America;Lymphoid Tissue;Macrophage;Maps;Mediating;member;Microglia;MicroRNAs;Modeling;mortality;mouse model;mutant;Myeloid Cells;nanoluciferase;Neurons;neurotropic virus;neurovascular unit;New England;novel;pathogen;Pericytes;Peripheral;Phenotype;prevent;Publishing;receptor;Registries;response;Role;Route;Sentinel;Serum;Signal Transduction;Site;South America;subcutaneous;Testing;Therapeutic;trafficking;transcytosis;Tropism;ultra high resolution;United States;United States National Institutes of Health;vector mosquito;vector-borne;Venezuelan;Venezuelan Equine Encephalitis Virus;Viral;Viral Vector;Virulence;Virulence Factors;Virus;Virus Replication;Western Equine Encephalitis Virus

PROJECT_TITLE: Viral and host factors in neuroinvasion of encephalitis alphaviruses


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Hematopoietic stem cells (HSCs) have the ability to generate all blood cell types and are the cornerstone of bone marrow transplantation. Despite extensive research on how HSCs become committed to mature blood cells, metabolic cues that instruct HSCs to commit to the erythroid lineage remain unknown. Our study aims to unravel how iron affects the erythroid gene expression and erythroid differentiation of HSCs.

PI_NAMEs: NAKADA, DAISUKE  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Affect;alpha ketoglutarate;Anemia;Blood Cells;Bone Marrow;Bone Marrow Transplantation;Cell Lineage;cell type;chemotherapy;cofactor;Cues;demethylation;differentiation in vitro;Dioxygenases;DNA;Erythroid;erythroid differentiation;Erythropoiesis;Exhibits;Gene Expression;Genes;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Hematopoietic System;Hemolytic Anemia;Heterogeneity;Homeostasis;in vivo;Inflammation;insight;Iron;Iron Chelating Agents;Iron Chelation;Metabolic;Modeling;Natural regeneration;novel;novel strategies;prevent;Proteins;Regenerative Medicine;Research;Role;Signal Transduction;Source;stem cell population;Stress;stressor;uptake

PROJECT_TITLE: Mechanisms that regulate erythroid differentiation of hematopoietic stem cells

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE This randomized trial will assess the feasibility, effectiveness, and cost-effectiveness of telemedicine-based glaucoma screening for high-risk populations using optical coherence tomography (OCT), intraocular pressure (IOP), and visual field assessment. The targeted population will consist of Black individuals ≥ 50 years, Latino individuals ≥ 65 years, and people with diabetes who receive care at a Federally Qualified Health Center in northern California. This study is of public health relevance because it addresses the long-term goal of reducing blindness due to glaucoma through telemedicine screening approaches in areas with poor access to care.

PI_NAMEs: KEENAN, JEREMY DAVID (contact);OU, YVONNE

PROJECT_TITLE: DP24-081 Novel telehealth technologies to detect and manage glaucoma and vision-threatening eye diseases in high-risk populations


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Fatigue is a significantly disabling symptom for many Veterans with MS (VwMS) that is poorly managed with no available US FDA approved therapies. A survey of more than 400 Veterans with MS (Hatzakis et al. 2005), 68% reported moderate or high fatigue levels and only 40% were prescribed non FDA approved fatigue-modifying medications. Research suggests failure of the energy production pathways in the nerve cells to contribute to MS fatigue, therefore novel therapies targeting these pathways are needed. Oral Mitoquinol (MitoQ), an antioxidant may improve nerve function by improving nerve cell energy pathways that may improve fatigue, cognition, quality of life and mood in VwMS. This 12-week study will primarily evaluate the effects of two different (20 or 40 Mg) but once daily dose of MitoQ or placebo on fatigue in VwMS and explore effects on other MS symptoms and blood immune and oxidative stress markers. We will evaluate outcomes at baseline, 6 and 12 weeks post study initiation and compare them in those receiving active study drug versus placebo.

PI_NAMEs: YADAV, VIJAYSHREE  (contact)

PROJECT_TERMS: Adult;Affect;Affinity;Amantadine;Antioxidants;Area;Beck depression inventory;Biological Markers;Blood;Blood Tests;blood-brain barrier crossing;Caring;Central Nervous System;chemical group;Chronic Disease;Clinical;Clinical Trials;Coenzyme Q10;Coenzymes;cofactor;Cognition;cognitive function;Complex;cost;Data;Demyelinations;design;Diagnosis;Digit structure;disability;Disabling;disabling symptom;Disease;Dose;Double-Blind Method;efficacy evaluation;Enrollment;Failure;Fatigue;FDA approved;Functional disorder;gastrointestinal system;Goals;Health Care Costs;Healthcare Systems;High Prevalence;Hour;Immune;Impaired cognition;improved;Inflammation;Inflammatory;innovation;Intestinal Absorption;Knowledge;Link;Measures;Mental Depression;Methods;Mitochondria;mitochondrial dysfunction;mitoquinone;Modafinil;Modality;Modification;Moods;Multiple Sclerosis;multiple sclerosis patient;multiple sclerosis treatment;Nerve;Nerve Degeneration;Neurons;new therapeutic target;novel;novel strategies;off-label use;Oral;oral supplementation;Outcome;Oxidative Stress;Oxidative Stress Induction;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Personal Communication;Persons;Pharmaceutical Preparations;Phase II Clinical Trials;Pilot Projects;pilot trial;Placebo Control;placebo controlled trial;placebo group;Placebos;Plasma;Play;Production;Publications;Quality of life;Quinones;Reporting;Research;Research Design;Research Personnel;Resource Allocation;Ritalin;Role;Safety;screening;Services;Severities;side effect;Stimulant;Study Subject;Surveys;Symptoms;Telephone;Testing;Time;treatment duration;treatment program;trend;ubiquinol;Ubiquinone;Veterans;Veterans Health Administration;Visit;Work

PROJECT_TITLE: MitoQ for Fatigue in Multiple Sclerosis: A Placebo Controlled Trial


ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: Delays and waits for needed health care result not only in lower patient satisfaction but adverse impacts on patient outcomes. While VHA has long struggled with access problems as a result of influxes of Veterans after wartime or in response to needs of new (e.g., traumatic brain injury) or aging cohorts (e.g., long term care), VHA's highly publicized access crisis in 2014 drew demands for immediate action. That action has taken the form of expansion of Veterans' access to community providers and policy and practice action within the VA. Improving how VHA manages access through more effective deployment of clinic personnel, resources, and processes to achieve timely access is a top priority. Oddly, the evidence base on effective access management strategies remains scant, requiring new approaches to accelerating how research can support VHA access improvement efforts. The proposed study aims to provide a national profile of how VHA has responded to the access crisis, and explore what drives or hinders successful efforts to improve access.

PI_NAMEs: ROSE, DANIELLE ELISE (contact)

PROJECT_TERMS: Acceleration;Address;Aging;Agreement;Appointment;Area;care coordination;Caring;Characteristics;Client satisfaction;Clinic;cohort;Communication;Communities;Community Networks;Consensus;contextual factors;Contracts;Data;Data Sources;demographics;Development;evidence base;evidence based guidelines;Evidence based practice;experience;Fostering;Foundations;Future;Geography;Group Practice;Health Services Accessibility;Healthcare;Healthcare Systems;Heart Diseases;Hour;Human Resources;implementation evaluation;Improve Access;improved;indexing;Individual;informant;Intervention;Leadership;Link;Long-Term Care;Malignant Neoplasms;Measures;medical specialties;meetings;Mental Health;Methods;Morbidity - disease rate;mortality;novel strategies;Outcome;patient population;Patient Self-Report;Patient-Focused Outcomes;Patients;Perception;Performance;Persons;physical conditioning;Policies;policy recommendation;post-traumatic stress;Primary Care;Primary Care Physician;Process;Provider;Quality of life;rapid growth;Recommendation;recruit;Reporting;Research;Resources;response;Role;Rural;rural area;Statutes and Laws;Survey Methodology;Surveys;Techniques;tool;Traumatic Brain Injury;uptake;Validation;Variant;Veterans;virtual;Wait Time;Whistle Blower;Work

PROJECT_TITLE: Impacts of Organizational Variations on Access Management

STUDY_SECTION_NAME: HSR-5 Health Care System Organization and Delivery and Women's Health[HSR5]


ORG_CITY: ANN ARBOR

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: MI

PHR: Major recent transformations in health care financing and delivery within and outside of the Department of Veterans Affairs (VA) are now presenting Veterans with unprecedented health care choices. These choices give Veterans opportunities to make decisions about their use of VA and non-VA health care that optimize the timeliness, affordability, quality, and patient-centeredness of their care. However, these decisions also carry great potential for unintended consequences if they are not well-informed. Despite such high stakes, little is known about how Veterans are currently making decisions about using VA and non-VA health care, what information they want to use in this decision-making, and how the provision of information to Veterans about their health care options could be improved. This research will examine how Veterans are now making decisions about using VA and non-VA health care and identify promising new strategies to better support Veterans in making well-informed, personalized decisions about their VA and non-VA health care options.

PI_NAMEs: KULLGREN, JEFFREY  (contact)

PROJECT_TERMS: Acceleration;care preference;Caring;Characteristics;Communities;Community Healthcare;Community Networks;Complex;Decision Making;Deductibles;design;Eligibility Determination;Evolution;experience;Focus Groups;Geography;Health;health care cost/financing;health care service;health care settings;health plan;Healthcare;Healthcare Systems;improved;innovation;insight;Interview;Learning;Low income;Measures;Medicaid;Methodology;Methods;Participant;patient oriented;patient population;Perception;personalized decision;Policies;Policy Analysis;Privatization;Process;programs;Provider;public health insurance;Qualitative Methods;Reporting;Research;Resource Allocation;Sampling;Science;Services;Source;Statutes and Laws;Structure;success;Surveys;System;Translations;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Optimizing Veteran Decision-Making About Use of VA and Non-VA Health Care

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Vector-Borne Diseases

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Rift Valley fever virus (RVFV) is widespread throughout the entire African continent and in some endemic areas over 50% of the population is exposed by adulthood. Activity of the innate immune system is key to mitigating the severity of disease and the virus has actively evolved ways to abrogate innate immune function. In this project we will define how biologically relevant primary human cells recognize and respond to RVFV infection, determine which innate signaling pathways function to provide protection from disease, and define the contribution of hematopoietic cell infection to in vivo pathogenesis.

PI_NAMEs: MCELROY, ANITA K (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Acute;Adult;African;antagonist;Anti-viral Response;Area;Biological Response Modifiers;Cell Compartmentation;cell type;Cells;Clinical;Data;defined contribution;Disease;Encephalitis;Exhibits;Fever;Genes;Goals;Hematopoietic;Hepatitis;Hepatocyte;Human;human data;IFNAR1 gene;Immune;In Vitro;in vivo;Infection;innate immune function;innate immune mechanisms;Innate Immune Response;Innate Immune System;interferon antagonist;Interferon Inducers;Interferon Type I;Interferons;Knowledge;Macrophage;Mediating;monocyte;Mononuclear;Mus;Natural Immunity;Neurons;pathogen;Pathogenesis;Phagocytes;Population;prevent;Prevention;Production;programs;Proteins;receptor;Recombinants;Research;response;Rift Valley fever virus;Role;Secondary to;sensor;Severity of illness;Signal Pathway;Signal Transduction;Single Nucleotide Polymorphism;Testing;Tissue-Specific Gene Expression;TLR3 gene;TNF gene;Viral;Viral Pathogenesis;Virus;Virus Diseases;virus host interaction;virus identification;Virus Replication

PROJECT_TITLE: Innate immune recognition and response to Rift Valley fever virus


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Genetics;Infectious Diseases;Malaria;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Emergence of Plasmodium falciparum strains with resistance to first-line artemisinin-combination therapies threatens malaria control and elimination efforts across the Horn of Africa. Improved understanding of the epidemiology and determinants of drug-resistant falciparum malaria, including infections by drug- and diagnostic-resistant strains with hrp2/3 deletions, is needed to inform clinical management and policy decisions in the region. We will conduct population surveys across Ethiopia and characterize resistant parasites, integrating our findings into a point-of-care clinical tool for identifying individuals with drug-resistant falciparum malaria and into a model to predict the future spread of resistance mutations.

PI_NAMEs: PARR, JONATHAN BOYD (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: accurate diagnosis;Address;Affect;Africa;alternative treatment;Anti-malarial drug resistance;Anti-malarials;arm;Artemisinins;Behavioral;Cessation of life;Clinic;Clinical;clinical care;Clinical Management;clinical practice;clinical predictors;clinical risk;Collaborations;Collection;Combined Modality Therapy;Communities;Complex;cost;Country;Culicidae;Data;Deletion Mutation;design;Detection;Development;Diagnosis;Diagnostic;diagnostic strategy;Diagnostic tests;Drug resistance;effective therapy;Environment;Epidemiology;Ethiopia;Ethiopian;experimental study;Falciparum Malaria;fitness;Future;Gene Deletion;Genes;Genetic;Genetic Polymorphism;Health;Health care facility;Horns;HRP-2 protein;Human;human model;improved;In Vitro;in vivo;Incidence;Individual;Infection;Investments;Malaria;Mediating;migration;Modeling;Monitor;Movement;multiple data sources;Mutation;Parasite resistance;Parasites;Persons;Pharmaceutical Preparations;Plasmodium falciparum;point of care;Policies;Population;population survey;Positioning Attribute;predictive modeling;predictive tools;pressure;Prevalence;prevent;programs;prospective;Public Health;rapid diagnosis;Rapid diagnostics;Regimen;Reporting;Residencies;Resistance;resistance mutation;Resistance to infection;resistant Plasmodium falciparum;resistant strain;Risk;Risk Factors;risk prediction model;Selection for Treatments;Statistical Models;Surveys;Testing;therapy design;Time;tool;transmission process;Travel;treatment strategy;Uncertainty;Vertebral column

PROJECT_TITLE: Epidemiology and determinants of emerging artemisinin-resistant malaria in Ethiopia

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Clinical Research;Data Science

ORG_CITY: MOSCOW

ORG_NAME: UNIVERSITY OF IDAHO

ORG_STATE: ID

PHR: PROJECT NARRATIVE This supplement requests critical upgrades at the University of Idaho Imaging and Data Acquisition Core, part of the larger INBRE Data Science Core. The equipment includes a super- resolution structured illumination microscopy (Deep SIM) add-on to the current Crest X-Light V3 confocal microscope and an additional, independent epifluorescence/widefield microscope system. These upgrades will allow Idaho researchers to keep pace with recent surges in demand for high-performance microscopy. This, in turn, will directly contribute to Idaho biomedical research productivity and competitiveness.

PI_NAMEs: BOHACH, CAROLYN HOVDE (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: 10 year old;Administrative Supplement;Award;Biomedical Research;Centers of Research Excellence;Collaborations;college;Confocal Microscopy;Core Facility;data acquisition;Data Science Core;Development;Equipment;equipment acquisition;Faculty;Fees;Flow Cytometry;Fluorescence-Activated Cell Sorting;Funding;Grant;Idaho;Image;Image Analysis;imaging platform;Infrastructure;innovation;Institution;Investments;Light;Lighting;Microscope;microscopic imaging;Microscopy;Modeling;multidisciplinary;Performance;Productivity;programs;Research;Research Personnel;Research Project Grants;Research Support;Structure;superresolution microscopy;System;Technology;ultra high resolution;United States National Institutes of Health;Universities

PROJECT_TITLE: Idaho INBRE Program- Equipment Supplement


ORG_CITY: RALEIGH

ORG_NAME: NC STATE DEPT OF AGRI AND CONSUMER SERV

PHR: Rollins-Vet-LIRN 2024: Studies on Antimicrobial Resistance in Bacteria of Veterinary Importance Project Narrative Today, emergence of antibiotic resistant bacteria is considered as a global threat. Prudent susceptibility testing and use of antibiotics will help us to reduce the antibiotic resistance burden. The NCVDLS Bacteriology laboratory wishes to engage in cooperative agreement opportunities with the FDA Vet-LIRN and the Vet-LIRN network of veterinary diagnostic laboratories to promote the areas of food and feed surveillance, antibiotic susceptibility testing, quality management, promote animal health and feed and food safety and security and provide surge capacity for large-scale testing in the event of an emergency.

PI_NAMEs: THACHIL, ANIL J;TRYBUS, JAMES  (contact)

PROGRAM_OFFICER_NAME: CERIC, OLGICA

PROJECT_TITLE: FDA-VET-LIRN Grant


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: Loma Linda

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: LOMA LINDA UNIVERSITY

PHR: Project Narrative The overall goal of the proposed study is to improve the understanding of JAK2 inhibitor-induced drug resistance in Ph-like ALL. Furthermore, we will prove that the conserved mechanism of cell differentiation induced upon inhibition of the JAK2/STAT5 signaling pathway can be effectively harnessed for therapeutic targeting of Ph-like ALL cells. By characterizing the biology and mechanisms of drug resistance, we will develop specific multi- targeting treatment strategies for subsequent clinical translation to improve overall survival of patients with Ph- like ALL.

PI_NAMEs: HURTZ, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: ABL1 gene;acute lymphoblastic leukemia cell;Acute Lymphocytic Leukemia;addiction;Adult;Age;Animals;Apoptosis;B cell differentiation;B-Cell Activation;B-Cell Acute Lymphoblastic Leukemia;B-Cell Antigen Receptor;B-cell precursor acute lymphoblastic leukemia cell;Bioinformatics;Biology;Breast Cancer Patient;Cell Death;Cell Differentiation Induction;Cell Line;Cell Proliferation;Cell Survival;cell type;Cells;Cellular Stress;Cessation of life;CHEK1 gene;chemotherapy;Child;clinical translation;Complex;Critical Pathways;cytokine;Cytokine Receptors;cytotoxicity;Dasatinib;Data;defined contribution;Development;DNA;DNA Damage;DNA Double Strand Break;Down-Regulation;Drug resistance;endonuclease;Enzyme Induction;Enzymes;experimental study;flexibility;Gene Expression;Gene Expression Profile;Genetic;Genetic Heterogeneity;Goals;Heterochromatin;high risk;Human;human disease;improved;improved outcome;In Vitro;in vivo;inhibitor;innovation;JAK1 gene;JAK2 gene;kinase inhibitor;Lesion;leukemia;leukemia treatment;Leukemic Cell;loss of function;Mediating;Molecular;mortality;mouse model;Mus;Mutate;Mutation;novel therapeutic intervention;Oncogenes;Oncogenic;patient derived xenograft model;Patient-Focused Outcomes;Patients;Ph+ ALL;pharmacologic;Philadelphia Chromosome;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;PI3K/AKT;PIK3CG gene;pre-clinical;Pre-Clinical Model;preclinical study;prevent;Proliferating;protective pathway;Proto-Oncogene Proteins c-akt;PTPN6 gene;Receptor Signaling;Relapse;relapse prevention;relapse risk;repaired;Research;response;Sampling;Signal Induction;Signal Pathway;Signal Transduction;Signaling Molecule;Source;src-Family Kinases;Stat5 protein;success;synergism;targeted treatment;Techniques;Testing;Therapeutic;therapeutic target;therapeutically effective;Toxic effect;Training;translational study;Treatment Protocols;treatment strategy;Uncertainty;V(D)J Recombination

PROJECT_TITLE: Targeting Kinase Inhibitor Induced Signaling Plasticity in Patients with Ph-Like ALL

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI(B)-I]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Back Pain;Bioengineering;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD);Neurosciences;Pain Research;Sleep Research

ORG_CITY: YPSILANTI

ORG_NAME: ARBOR MEDICAL INNOVATIONS, LLC

PHR: Narrative This application requests support to address the unanticipated increased scope of the VERABANDTM project so that we can successfully complete the FDA review process and obtain 510(k) clearance for the technology.

PI_NAMEs: KRUGER, GRANT H (contact)

PROGRAM_OFFICER_NAME: HUDAK, ERIC MICHAEL

PROJECT_TERMS: actigraphy;Address;Algorithms;Award;Chronic low back pain;Clinical;commercialization;Devices;Ensure;Measures;Medical Device;Pain management;Phase;Physicians;Process;Recording of previous events;Regulation;Reporting;Request for Applications;Sleep;Small Business Innovation Research Grant;Software Validation;System;Technology;Work

PROJECT_TITLE: Actigraphy Enhanced Clinical Chronic Lower Back Pain Management: Sleep Algorithm Assessment


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

PHR: Project Narrative G-protein coupled receptor kinase-2 (GRK2) is upregulated in several cardiac diseases including hypertrophy, hypertension, and heart failure. In this proposal, we seek to determine the mechanism by which phosphorylation of GRK2 at S670 alters mitochondrial function, metabolism, and cell death signaling pre- and post- cardiac injury. The long-term goal of our work is to exploit phosphorylation of GRK2 at S670 and its downstream signaling to develop new pharmacological strategies to treat cardiac diseases.

PI_NAMEs: SATO, PRISCILA  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Adult;Affect;Amplifiers;aorta constriction;Cardiac;Cardiac Myocytes;CASP3 gene;Catecholamines;Cell Death;Cell Death Induction;Cell Death Signaling Process;Cell Line;Cell membrane;Cell Physiology;Cell Survival;Cellular Stress;Chronic;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;Cytosol;Decarboxylation;desensitization;design;Development;Disease;Disease Progression;Enzymes;experimental study;Functional disorder;G protein coupled receptor kinase;G Protein-Coupled Receptor Signaling;G-Protein Signaling Pathway;G-Protein-Coupled Receptors;Glucose;glucose metabolism;Goals;Heart;heart damage;Heart Diseases;Heart failure;Heart Hypertrophy;Heart Injuries;heart metabolism;Hypertension;Hypertrophy;Hypoxia;inhibitor;innovation;Ischemia;Knock-in Mouse;Knock-out;Knockout Mice;Length;Link;Lytic;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Metabolic;Metabolic syndrome;Metabolism;Mitochondria;mitochondrial creatine kinase;mitochondrial metabolism;mouse model;Mus;Myocardial;Myocardial dysfunction;Myocardial Infarction;Myocardial Ischemia;novel;optogenetics;Outcome;oxidation;Oxidative Phosphorylation;p38 Mitogen Activated Protein Kinase;Pathologic;Pathology;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Pharmacological Treatment;Phosphorylation;Phosphorylation Inhibition;Physiological;Play;Post-Translational Protein Processing;Proteins;Pyruvate;pyruvate dehydrogenase;receptor recycling;Regulation;Reperfusion Injury;Reporting;Research;Resolution;response;response to injury;Role;Signal Transduction;Signaling Molecule;SLC25A4 gene;Stress;Testing;Treatment Failure;Work

PROJECT_TITLE: Dysregulation of cardiac signaling in disease and stress

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


ORG_CITY: IRVINE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Although obesity is a major risk factor for type 2 diabetes, only about 30% of obese patients develop diabetes due to their genetic risk. The current proposal identifies genetic variants that reduce a gene called ZC3H13, leading to impaired function of insulin-producing cells. The results may help develop tools to identify high-risk obese patients for diabetes prevention and early intervention.

PI_NAMEs: YANG, QIN  (contact)

PROGRAM_OFFICER_NAME: ZAGHLOUL, NORANN

PROJECT_TERMS: 3' Untranslated Regions;Binding;Binding Proteins;Binding Sites;Biological Assay;causal variant;Cell Nucleus;Cell Physiology;Cells;Complex;CRISPR/Cas technology;Data;deep learning model;Development;Diabetes Mellitus;Diabetes prevention;diabetes risk;diabetic;Disease;Distal;Early Intervention;epitranscriptomics;Exhibits;Failure;Gene Expression;gene function;Genes;Genetic Predisposition to Disease;Genetic Risk;genetic risk factor;genetic variant;genome editing;genome wide association study;Genotype;Genotype-Tissue Expression Project;Heterozygote;High Fat Diet;high risk;Human;impaired glucose tolerance;Impairment;Insulin;Insulin deficiency;Insulin Resistance;islet;knock-down;Knock-out;Knockout Mice;Length;Link;Linkage Disequilibrium;Maps;Mediating;Messenger RNA;Methyltransferase;MicroRNAs;Modification;molecular phenotype;Mutagenesis;Non-Insulin-Dependent Diabetes Mellitus;novel;Nuclear;obese patients;obese person;Obesity;Overweight;Pancreas;Pathogenesis;Patients;Polyadenylation;Positioning Attribute;Post-Transcriptional Regulation;preventive intervention;Production;protein expression;protein function;Protein Isoforms;Proteins;Proteomics;Quantitative Trait Loci;Regulation;Regulatory Element;Risk;Risk Factors;RNA;RNA Processing;RNA-Binding Proteins;Site;statistics;Susceptibility Gene;tool;Transcript;transcriptome sequencing;transcriptomics;Untranslated RNA;Variant;Zinc Fingers

PROJECT_TITLE: Alternative polyadenylation as a novel mechanism for diabetes

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Digestive Diseases;Dissemination and Implementation Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Methamphetamine;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

PHR: Narrative The proposed study will test the effectiveness, implementation outcomes, and cost effectiveness of a community-tailored, peer-driven “intravention” to reduce risk for overdose, hepatitis C, skin and soft tissue infections, and HIV in Appalachian Kentucky counties with extensive unmet harm reduction needs.

PI_NAMEs: YOUNG, APRIL MARIE (contact)

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: Address;Appalachian Region;child protective service;Client;cohort;Collaborations;Communities;Community Health;community partners;condoms;cost;cost effectiveness;Cost Effectiveness Analysis;County;Coupled;Data;Death Rate;Disease Outbreaks;Drug usage;Drug user;Effectiveness;effectiveness study;effectiveness testing;Epidemic;Equipment;Event;evidence base;Evidence based intervention;experience;follow-up;Fright;Harm Reduction;Health;Hepatitis C;high risk;HIV;HIV diagnosis;HIV risk;HIV/HCV;Human immunodeficiency virus test;Hybrids;implementation intervention;implementation outcomes;implementation strategy;improved;Individual;Infection;infection risk;Infectious Skin Diseases;Infrastructure;Injecting drug user;Injections;innovation;Intervention;Judgment;Kentucky;Knowledge;Law Enforcement;marginalization;marginalized population;mathematical model;member;methamphetamine use;Modeling;Names;Needle Sharing;Needle-Exchange Programs;Opioid;opioid use disorder;outreach program;Overdose;overdose death;overdose risk;overdose risk behaviors;peer;Penetration;Persons;Pharmaceutical Preparations;Privacy;Process;Quasi-experiment;Reporting;Research;Research Personnel;response;Risk;Risk Reduction;Rural;Rural Appalachia;rural area;Rural Community;Rural Population;rural setting;Safety;scale up;Science;Scientist;service delivery;Service delivery model;service utilization;Services;Shapes;social stigma;Soft Tissue Infections;Sorbus;Sterility;Stimulant;Structure;substance use;success;Testing;Transcend;Trust;Visit

PROJECT_TITLE: Engaging People Who Use Drugs in Harm Reduction Service Delivery: An Intravention to Reduce Risk of HIV, HCV, Overdose, and Injection-related Infections in Rural Appalachia

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 MXS-E (A1)]


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Reductions in kidney blood flow can lead to permanent damage to the kidneys, known as chronic kidney disease, which can progress to complete loss of kidney function and can shorten life span. We propose to investigate whether information about kidney blood flow that we will obtain from contrast enhanced ultrasound will help identify which individuals with chronic kidney disease are at high risk of experiencing progressive loss of kidney function. The high-risk individuals can then be included in future clinical trials to test new treatments for chronic kidney disease.

PI_NAMEs: SRIVASTAVA, ANAND  (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Affect;Age;Animals;Atrophic;Biological Markers;biomarker development;biomarker evaluation;biomarker selection;biomarker validation;Blood flow;Blood Vessels;Cardiovascular Diseases;cardiovascular disorder risk;career development;Chronic;Chronic Kidney Failure;Clinical;Clinical Trials;clinically relevant;Collaborations;contrast enhanced;Contrast Media;Data;Data Analyses;Development;Development Plans;Disease;disease phenotype;Disease Progression;End stage renal failure;Enrollment;Environment;Erythrocytes;Evaluation;experience;Fibrosis;Functional Imaging;Future;Gases;Glomerular Filtration Rate;glomerulosclerosis;Goals;Grant;Health;healthy volunteer;high risk;high risk population;Histopathology;human data;Hypoxia;Image;Image Analysis;imaging biomarker;imaging modality;improved;Individual;Injury;interstitial;Investigation;Iohexol;Japanese;Kidney;kidney biopsy;Kidney Diseases;kidney fibrosis;Lead;learning strategy;Lesion;life span;Link;Measures;Mentors;Mentorship;Microbubbles;Microcirculation;Microvascular Dysfunction;mortality;Motion;Multicenter Studies;multidisciplinary;non-invasive imaging;novel;novel therapeutics;Outcome;Pathogenesis;patient oriented research;Patients;Performance;Perfusion;Population;Positioning Attribute;premature;prognostic value;Property;prospective;Proteinuria;Protocols documentation;recruit;Renal Blood Flow;renal damage;Renal function;Reporting;Research;Research Personnel;research study;Risk;skill acquisition;skills;study population;Testing;Time;tool;Training;Translations;Tubular formation;Ultrasonography;ultrasound;Universities

PROJECT_TITLE: Non-Invasive Imaging Biomarkers to Identify a High-Risk Chronic Kidney Disease Phenotype

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Approximately 10-20% of toddlers fail to meet speech and language milestones by their second birthday. Despite its prevalence, the underlying mechanisms, predictors, and developmental profiles of these “late talkers” remain poorly understood. This proposal aims to combine three large extant datasets to characterize the neural trajectories and psychosocial factors that underlie late talking during infancy, before children begin to fall behind, which could pave the way for early identification of children at elevated likelihood of language delay and disorder and provide the opportunity to intervene when intervention may be the most effective for preventing cascading adverse language and socioemotional outcomes.

PI_NAMEs: WOODRUFF CARR, KALI L (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Address;adverse outcome;Affect;Autism Diagnosis;autism spectrum disorder;Behavior;Behavioral;biopsychosocial;biopsychosocial factor;Black race;Caregivers;Child;Child Rearing;Code;community clinic;Control Groups;Data;Data Analyses;Data Set;data sharing;Demographic Factors;Development;Diagnosis;Early identification;Education;Electroencephalography;Emotional;Ensure;Environment;Environmental Risk Factor;Equipment and supply inventories;Family;Family history of;Foundations;Future;Genetic Transcription;Goals;Grouping;Hispanic;Hybrids;Impairment;improved;Income;indexing;Individual Differences;Inequity;infancy;Infant;Intercept;Intervention;Knowledge;Language;Language Delays;Language Development;Language Disorders;language impairment;language outcome;large datasets;Learning;Linguistics;Logistic Regressions;longitudinal dataset;Longitudinal Studies;Matched Group;Measures;meetings;Modeling;neural;Neurocognitive;Neurologic;neuromechanism;Nursery Schools;Outcome;Parent-Child Relations;Pattern;peer;power analysis;predictive modeling;Prevalence;prevent;Process;promote resilience;protective factors;psychosocial;Psychosocial Factor;public database;Recording of previous events;recruit;Research;Resources;Rest;Risk;Risk Factors;risk prediction;Sampling;screening;secondary analysis;sharing platform;Siblings;Socioeconomic Status;socioeconomics;Speech;Time;Toddler;United States National Institutes of Health;Variant

PROJECT_TITLE: Early Predictors of Late Talking: EEG Trajectories and Psychosocial Profiles

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-R (51)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Emergency Care;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Prevention;Primary Health Care;Social Determinants of Health;Substance Misuse

ORG_CITY: PROVIDENCE

ORG_NAME: MIRIAM HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE  People with opioid use disorder (OUD) have limited access to HIV prevention services, especially HIV screening, HIV pre-exposure prophylaxis (PrEP), and medication for OUD (MOUD). The integration of HIV prevention services into care settings where people with OUD is promising to expand HIV prevention services and reduce HIV incidence in the long run. This study will propose an innovative and multidisciplinary project to quantify healthcare usage (All Payers Claims Database (APCD) and State Emergency Department Database (SEDD)), identify optimal strategies to integrate HIV prevention services and MOUD into clinical settings (implementation methodology guided workgroup), and estimate the effect of selected implementation strategies on reducing HIV incidence among people with OUD who are at great risk of HIV acquisition (mathematic modeling).

PI_NAMEs: CHAN, PHILIP ANDREW;TAO, JUN  (contact)

PROJECT_TERMS: Accident and Emergency department;Address;Advocate;AIDS prevention;American;Behavior;Belief;care seeking;Caring;Censuses;Clinic;Clinic Visits;Clinical;clinical care;Clinical Trials;Code;Communities;Community Surveys;Continuity of Patient Care;cost effective;Country;Data;Databases;Development;Diagnosis;Disease Outbreaks;Emergency department visit;Evaluation;evidence base;Frequencies;Goals;health assessment;health care service utilization;health care settings;Health Care Visit;health data;Healthcare;Healthcare Systems;high risk;high risk sexual behavior;HIV;HIV Infections;implementation strategy;improved;Incidence;Individual;Infrastructure;injection drug use;Injections;innovation;Insurance;interdisciplinary approach;Intervention;Legal;Lived experience;Location;mathematical model;medication for opioid use disorder;Mental Health;Methodology;Methods;Modeling;multidisciplinary;novel strategies;Nurses;opioid epidemic;opioid use;opioid use disorder;overdose death;patient engagement;Patients;Persons;Pharmaceutical Preparations;Physicians;Population;pre-exposure prophylaxis;prevent;prevention service;Prevention strategy;Preventive service;Primary Care;primary care clinic;primary outcome;Procedures;Process;Provider;Public Health;Resources;Rhode Island;Risk;Risk Factors;screening;service utilization;Services;social;social health determinants;social stigma;Social Work;Socioeconomic Status;substance use treatment;Testing;transmission process;treatment center;Uninsured;United States;Vulnerable Populations;Work

PROJECT_TITLE: A multidisciplinary approach to integrate HIV prevention services into clinical care settings for people with opioid use disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 TXT-E (A1)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Kidney Disease;Liver Disease;Organ Transplantation;Pediatric;Transplantation

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Adolescent/young adult kidney or liver transplant recipients have unacceptably high rates of immunosuppressant medication nonadherence and, thus, are at elevated risk for nonadherence-related organ rejection, graft loss, or death. Our research involves (1) validating a new, non-invasive Real-Time Adherence Measure based on real- time adherence data easily downloaded from electronic pillboxes to accelerate provider identification of when nonadherence puts patients at risk for rejection, and (2) designing and pilot testing an innovative just-in-time adaptive mobile health intervention, leveraging real-time electronic pillbox data to support in-the-moment adherence at the point of medicine dosing. Both of our clinical tools have immense public health potential for improving medication adherence, reducing nonadherence-related health problems, and improving health-related quality of life among AYA kidney or liver transplant recipients and for other people taking daily medicine for chronic illnesses.

PI_NAMEs: EATON, CYD KUMIKO (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Acceleration;adaptive intervention;Address;Adherence;Adolescent;Adolescent and Young Adult;American;Biological;Blood;career development;Cessation of life;Chronic Disease;Chronic Kidney Failure;Clinical;compliance behavior;Data;Databases;design;Dose;dose information;efficacious intervention;electronic adherence monitoring;electronic data;Electronics;Experimental Designs;Goals;graft failure;Health;health related quality of life;Immunosuppressive Agents;improved;indexing;Ingestion;innovation;instrument;Intervention;intervention effect;Investigation;Kidney Transplantation;Knowledge;Link;liver transplantation;Measures;medication compliance;medication nonadherence;Medicine;Methodology;Methods;mHealth;mhealth interventions;Monitor;novel;organ transplant rejection;Patients;Persons;Pharmaceutical Preparations;Phase;pilot test;Population;post intervention;Provider;Public Health;Qualitative Methods;Quality of life;Randomized;randomized trial;Reporting;Research;research and development;Research Methodology;Research Personnel;Risk;Signal Transduction;Societies;Tacrolimus;Technology;therapy design;Time;tool;Training;Training Activity;Transplant Recipients;Transplantation;uptake;young adult

PROJECT_TITLE: Leveraging Technology to Improve Medication Adherence in Adolescent and Young Adult Kidney or Liver Transplant Recipients


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Kidney Disease;Maternal Health;Pregnancy;Prevention;Women's Health Research

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Chronic kidney disease affects more than 2 million American women of childbearing age, and is associated with decreased fertility and increased risk of adverse pregnancy outcomes. Planning for pregnancy prior to conception is advocated for all women but is especially important for women with kidney disease because of their potential complications. This research will develop and test a decision aid that will help women and their kidney doctors share information to support informed decision making related to reproductive health care and pregnancy in women with kidney disease.

PI_NAMEs: OLIVERIO, ANDREA L (contact)

PROJECT_TERMS: acceptability and feasibility;Adult;adverse pregnancy outcome;Advocate;Affect;American;arm;Benefits and Risks;Biometry;Board Certification;career;career development;Caring;child bearing;Chronic Kidney Failure;Clinic;cohort;Collaborations;Communication;Computerized Medical Record;Conceptions;Conduct Clinical Trials;Counseling;Coupled;Data;Decision Aid;Decision Making;design;Development;Development Plans;Disease Management;Educational workshop;Effectiveness;effectiveness measure;effectiveness outcome;empowerment;Ensure;Etiology;Evaluation;evidence base;experience;Face;Female of child bearing age;Fertility;fetal;Fostering;Funding;Future;Goals;Grant;Health;Health education;Healthcare;high risk;High-Risk Pregnancy;improved;International;Internist;Intervention;Interview;K-Series Research Career Programs;Kidney;Kidney Diseases;Knowledge;Learning;Literature;Medicine;meetings;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Michigan;Morbidity - disease rate;Nephrology;offspring;Outcome;Patient Education;patient oriented;Patients;pediatrician;Physicians;pilot test;Planned Pregnancy;Population;Positioning Attribute;Pre-Eclampsia;Pregnancy;Pregnancy Outcome;premature;Preparation;Process;Prospective, cohort study;Randomized;Randomized, Controlled Trials;Regimen;Reproductive Health;Research;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Research Proposals;Risk;Sampling;satisfaction;Science;Scientist;Sexual Dysfunction;shared decision making;Site;skills;Structure;success;Surveys;Technology;Testing;Training;treatment as usual;Uncertainty;United States National Institutes of Health;Universities;Visit;Woman;Women's Health;women's reproductive health;Work

PROJECT_TITLE: Developing a decision aid for reproductive health for women with kidney disease


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Radiation Oncology;Social Determinants of Health

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative A new platform is envisioned that combines two existing technologies to produce a low cost, simple to use, handheld device that can screen patients for high-risk oral cancer, image the location of the cancer, and treat it using this same device at point of care. It includes testing therapeutic efficacy both pre-clinically and clinically in patients, along with identification of an easy-to-use topical application of the therapeutic agent well suited for low-income settings. The impact of these studies could be substantial in the low-income settings such as rural areas and can avoid deaths in the regions where oral cancer is highly prevalent in India as well as other countries including regions of the U.S.A.

PI_NAMEs: CELLI, JONATHAN P;HASAN, TAYYABA  (contact)

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: Acute;anti-cancer research;Award;Biomedical Research;Boston;cancer therapy;career;career development;cost;Deposition;Development;Dose;experience;Fluorescence;global health;Growth;Image;image guided;Journals;Malignant - descriptor;malignant mouth neoplasm;Massachusetts;Medical Technology;medically underserved population;Mentorship;Modeling;Optics;oral lesion;Photobleaching;Photosensitizing Agents;premalignant;programs;PUVA Photochemotherapy;Reporter;Research;Resource-limited setting;response;screening;System;Technology;three dimensional cell culture;Time;tissue phantom;Tissues;tumor;undergraduate student;Universities;Work

PROJECT_TITLE: A comprehensive platform for low-cost screening and image-guided photodynamic therapy (PDT) of pre-malignant and malignant oral lesions in low resource settings


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Neurodegenerative;Neurosciences

ORG_CITY: CLEVELAND

ORG_DEPT: PATHOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE The Neurodegeneration Training Program provides training to outstanding predoctoral students to become leaders of academic, clinical, or pharmaceutical research programs focused on neurodegeneration. The program emphasizes rigorous basic neurodegeneration research, mentored clinical experience with patients, and career development skills necessary for making successful translational advances for maintaining a healthy aging population.

PI_NAMEs: ZHU, XIONGWEI  (contact)

PROGRAM_OFFICER_NAME: KORN, STEPHEN J

PROJECT_TERMS: Neurodegenerative Disorders;Training

PROJECT_TITLE: Training in Neurodegenerative Diseases


ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE The proper spatial and temporal organization of organelles underlies many cellular processes including cell division, migration, differentiation, and communication. Mitochondria are essential organelles that can adapt their morphology and spatial distribution to changing environmental conditions–but the molecular mechanisms governing these physiological processes are still poorly understood, especially in morphologically complex cells like muscles and neurons, which suffer disproportionately from mitochondrial dysfunction during disease- and age-related degeneration. This project will provide fundamental and much-needed knowledge on the molecular mechanisms of regulated mitochondrial morphology for developing a molecular understanding of mitochondrial function in human cells.

PI_NAMEs: AYDIN, HALIL  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: age related;age-related disease;Apoptosis;Architecture;Biochemical Reaction;Bioenergetics;Cardiolipins;Cardiovascular Diseases;catalyst;Cell division;Cell Physiology;Cells;Characteristics;Communication;Complex;Crista ampullaris;Development;Disease;environmental change;Eukaryotic Cell;Guanosine Triphosphate Phosphohydrolases;Human;Impairment;Knowledge;Link;Lipids;Maintenance;Malignant Neoplasms;Membrane;Metabolism;migration;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Mitochondrial Proteins;Molecular;Molecular Abnormality;Morphogenesis;Morphology;Muscle;Neurodegenerative Disorders;Neurons;novel therapeutic intervention;Obesity;OPA1 gene;Organelles;Oxidative Phosphorylation;Pathology;Physiological Processes;Play;Probability;Process;Protein Dynamics;Proteins;Regulation;respiratory;Reticulum;Role;Shapes;Site;Spatial Distribution;Structure;success

PROJECT_TITLE: Regulation of mitochondrial morphology and functional versatility

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(50)-R]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Physical Rehabilitation;Rehabilitation

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE This diversity supplement aims to explore clinician and facility factors that influence implementation of a high- intensity rehabilitation intervention in skilled nursing facilities. The candidate will be guided by mentors in rehabilitation research and biostatistics to implement the proposed research. The mentorship team will provide the necessary guidance and support to ensure the candidate's success as she progresses towards establishing herself as an independent investigator and a prominent figure in the field of rehabilitation research.

PI_NAMEs: STEVENS-LAPSLEY, JENNIFER E. (contact)

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: Address;behavior change;Biometry;career development;Clinical;demographics;Development;Development Plans;Dissemination and Implementation;Education;Effectiveness;Ensure;experience;Future;Goals;Health;Healthcare;implementation determinants;implementation research;Influentials;innovation;insight;Intervention;Leadership;Linear Regressions;Mentors;Mentorship;Methods;older adult;Outcome;provider factors;rehabilitation paradigm;rehabilitation research;Rehabilitation therapy;Research;Research Personnel;Research Project Grants;Role;Self Efficacy;Skilled Nursing Facilities;skills;success;Techniques;Theoretical Domains framework;Training;translational framework

PROJECT_TITLE: Advancing Rehabilitation Paradigms for Older Adults in Skilled Nursing Facilities

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Childhood Obesity;Clinical Research;Diabetes;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_NAME: JOSLIN DIABETES CENTER

PHR: PROJECT NARRATIVE Cases of pre-diabetes and type 2 diabetes (T2D) in children and adolescents have been rising at alarming rates, which is concerning in light of data showing that T2D in youth is more severe and more likely to cause complications than T2D diagnosed in adulthood. Currently it is difficult to predict whether a child with pre- diabetes will go on to develop T2D. Our proposal aims to discover predictive biomarkers to identify youth at highest risk of progressing from prediabetes to T2D, which ultimately will allow for earlier detection and prevention.

PI_NAMEs: FLEISCHMAN, AMY DEBRA;ISGANAITIS, ELVIRA MARIE (contact);STANLEY, TAKARA LEAH

PROGRAM_OFFICER_NAME: BROADNEY, MIRANDA MARGUERITE

PROJECT_TERMS: acylcarnitine;Address;adiponectin;Adolescent;Adrenal Glands;Adult;Age;Alanine;Amides;Androgens;aptamer;Area;Arginine;Aromatic Amino Acids;Beta Cell;biobank;Biological;blood glucose regulation;Body Composition;Body mass index;Boston;Branched-Chain Amino Acids;career development;Cell Physiology;Characteristics;Child;Clinical;Clinical assessments;clinical center;clinical predictors;Clinical Research;cohort;Collaborations;Communities;community setting;Continuous Glucose Monitor;COVID-19 pandemic;Data;data repository;Detection;Development;Diabetes Mellitus;diabetes pathogenesis;diabetes risk;Diagnosis;Diet Surveys;Dual-Energy X-Ray Absorptiometry;Early Diagnosis;Enrollment;Environmental Risk Factor;Epigenetic Process;euglycemia;Evaluation;Evolution;Failure;Family history of;Fatty acid glycerol esters;Feces;fitness;Future;General Hospitals;Genomics;Geography;Goals;Gonadal Hormones;Gonadal Steroid Hormones;Grant;Growth;Growth Hormone Receptor;Hair;Hand Strength;Hepatic;high risk;Home;Hormonal;hormone binding protein;Hormones;Hyperglycemia;IGFBP1 gene;Incidence;inclusion criteria;incretin hormone;Individual;Insulin Resistance;insulin sensitivity;Insulin-Like Growth Factor I;Light;Manuscripts;Massachusetts;Measurable;Measures;Mediator;Metabolic;Metabolic Pathway;metabolome;metabolomics;Methodology;modifiable risk;multiple omics;Neighborhood Health Center;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Oral;Parents;Participant;Pathogenesis;Pathway interactions;Pediatric cohort;Pediatric Hospitals;Peptides;Peripheral Blood Mononuclear Cell;Phenotype;Physical activity;Plasma;Prediabetes syndrome;predictive marker;predictive modeling;predictive signature;prevent;Prevention;progression marker;prospective;Proteome;proteomic signature;Proteomics;Puberty;recruit;remote assessment;Reporting;repository;Risk;Risk Factors;Sampling;social factors;social health determinants;Somatotropin;Systems Biology;Techniques;Testing;Time;trend;type 2 diabetes in children;Ultrasonography;Urine;Virulence Factors;Visceral fat;VO2max;wearable device;Youth

PROJECT_TITLE: Understanding, Predicting and Preventing Type 2 Diabetes in Youth, Boston Clinical Center (UPP Study)


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Natural Products;Neurosciences;Opioids

PHR: NARRATIVE By modulating the activity of ligand gated ion channels (LGICs) and G-protein coupled receptors (GPCRs), complex natural products have the potential to reveal critical insight into the function of these therapeutically important membrane receptors. This proposal investigates the synthesis and evaluation of two classes of natural products and their development into new chemical tools to investigate LGIC and GPCR pharmacology. By providing new directions to rationally design small molecules that engage their receptors targets, the results from this research will ultimately lead to safer, more effective medicines.

PI_NAMEs: RILEY, ANDREW  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Agonist;Alkaloids;Area;Award;Biological Assay;Biological Process;Chemicals;Complex;Coupling;Development;drug discovery;Economics;Evaluation;Family;Future;G-Protein Signaling Pathway;G-Protein-Coupled Receptors;Health;Human;improved;Indole Alkaloids;inhibitor;insight;Ion Channel Gating;kappa opioid receptors;Laboratories;Libraries;Ligands;Medicine;member;Membrane;Methods;Monitor;Natural Products;Natural Source;Nicotinic Receptors;novel;Opioid;Pharmacology;Protocols documentation;rational design;receptor;Research;Route;scaffold;Signal Transduction;small molecule;Synthesis Chemistry;Techniques;Therapeutic;tool;Work

PROJECT_TITLE: Synthesis and Evaluation of Alkaloids to Probe Membrane Receptors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Kidney Disease;Pregnancy

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative  Human nephrogenesis is complete by 34-36 weeks gestation, with 60% of nephrons forming during the third trimester. Given improved survival of periviable gestational ages coupled with the fact that nephrogenesis continues for no more than 40 days after premature birth, preterm infants are at the low end of nephron endowment and at greater risk for chronic kidney disease and end stage renal disease in adulthood. Uncovering the molecular mechanisms governing primate-specific late gestation nephrogenesis will have a positive impact on the health of preterm infants by identifying potential druggable targets that will help extend this critical period postnatally.

PI_NAMEs: SCHUH, MEREDITH  (contact)

PROJECT_TERMS: 3-Dimensional;Adult;Advisory Committees;age related;age related changes;Anatomy;Animals;ATAC-seq;Award;Binding Sites;Bioinformatics;Biological Models;Birth;Callithrix;Callithrix jacchus jacchus;career development;Career Mobility;Cell Nucleus;cell stroma;Cells;certificate program;Chronic Kidney Failure;Coupled;CRISPR/Cas technology;critical period;Data;Data Set;Development Plans;druggable target;End stage renal failure;Endowment;Environment;epigenome;Fetal Kidney;Freezing;Future;gene regulatory network;Gene set enrichment analysis;Genes;Genetic;genetic manipulation;Genetic Transcription;Genomics;Germ Lines;Gestational Age;Goals;Health;high risk;Human;improved;In Situ Hybridization;Kidney;Kidney Diseases;Knowledge;laboratory experience;laser capture microdissection;Lateral;Life;Macaca mulatta;Maps;Metanephric Diverticulum;Methods;Modeling;Molecular;Molecular Biology;Morphology;multiple omics;Mus;nephrogenesis;nephron progenitor;Nephrons;nonhuman primate;novel;Outcome;Pathway interactions;periviable;Population;postnatal;postnatal period;Pregnancy;premature;Premature Birth;Premature Infant;prevent;Primates;Process;Research;Rhesus;Risk;RNA;Sampling;Second Pregnancy Trimester;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;stem cells;System;Technology;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;Third Pregnancy Trimester;Tissues;Training;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;TWIST1 gene;With laterality

PROJECT_TITLE: Bridging the gap of late gestation human nephrogenesis using a non-human primate model