PHR: ANIMAL SHARED RESOURCE- PROJECT NARRATIVE Not required per PAR-20-043

PI_NAMEs: MILLS, ALEA A. (contact)

PROJECT_TERMS: Address;Aging;Alleles;Animal Cancer Model;animal care;animal colony;animal facility;Animal Housing;Animal Husbandry;Animal Model;Animal Welfare;Animals;anti-cancer research;Antibodies;Area;Autopsy;Biopsy;Blood;Breeding;Cancer Biology;Cancer Center;Cancer Center at Cold Spring Harbor Laboratory;Cancer Center Support Grant;cancer imaging;Cancer Model;cancer therapy;Cell Culture Techniques;Collection;Colon;Colon Carcinoma;Colonoscopy;Computer software;Confounding Factors (Epidemiology);Conscious;Dedications;Development;Diet;Disease;Distal;Doctor of Philosophy;Doctor of Veterinary Medicine;Documentation;Dose;Electrocardiogram;energy efficiency;Engraftment;Ensure;Equipment;Evaluation;experimental study;Faculty;Funding;Generations;Genetic;Head;Heart Rate;high standard;Housing;human cancer mouse model;IACUC;Immunization;Immunocompromised Host;implantation;in vivo;in vivo Model;Infrastructure;Injections;innovation;insight;Laboratories;Maintenance;Malignant Neoplasms;Measurement;Mechanics;Medicine;member;Metabolism;Methods;Mission;Modeling;Molecular;Monitor;mouse model;Mus;novel;Operative Surgical Procedures;opportunistic pathogen;Organoids;Pathogenesis;Performance;Perfusion;Physiology;Plethysmography;pre-clinical;pre-clinical research;preclinical study;Procedures;programs;protocol development;Protocols documentation;Publications;Reproducibility;Research;Research Personnel;Resource Sharing;Resources;response;Rodent;Services;skills;Surgical Models;System;Tail;Tattooing;Techniques;Therapeutic;Time;Tissue Procurements;Tissues;Training;Translational Research;tumor progression;Update;Viral;Virus;Work

PROJECT_TITLE: Animal Shared Resource


ADMINISTERING_IC: DC

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

ORG_CITY: GAINESVILLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative. Parkinson’s disease (PD) is among the most common neurodegenerative conditions affecting adults worldwide. Deep brain stimulation (DBS) is an increasingly common option for managing PD symptoms. The proposed research is relevant to public health because it will directly address the effect(s) of DBS on communication (voice), and airway protection (swallowing & cough), both of which contribute to morbidity, mortality, and reduced quality of life in people with PD.

PI_NAMEs: HEGLAND, KAREN W (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acceleration;Acoustics;Address;adduct;Adjuvant;Adult;Affect;Age;Air Movements;Area;Behavior;Benefits and Risks;Bilateral;Brain region;Capsaicin;Caring;Cell Nucleus;clinical decision-making;cohort;Communication;Control Groups;Coughing;Cranial Nerves;Cues;Data;Deep Brain Stimulation;Deglutition;design;Disease;Dystonia;Effectiveness;Enrollment;Equipoise;Evaluation;experience;Fiber;Functional disorder;Globus Pallidus;Goals;Handedness;illness length;Image;improved;Individual;Inhalation;innovation;interdisciplinary approach;Internal Capsule;Knowledge;Larynx;Lead;Limb structure;Literature;Location;Measures;Mediating;Medication-Induced Dyskinesia;Meta-Analysis;Methods;Morbidity - disease rate;mortality;Motor;motor control;Motor Neurons;motor symptom;Nerve Degeneration;nerve supply;neural stimulation;neuroregulation;North America;Operative Surgical Procedures;Outcome;Outcome Study;Parkinson Disease;Pathway interactions;Patients;Periodicity;Persons;Physiological;Prevalence;Production;Prospective Studies;Public Health;Publishing;Quality of life;Refractory;Relative Risks;Reporting;Research;Safety;Severity of illness;Site;Speech;Spirometry;Structure of subthalamic nucleus;symptomatology;Symptoms;Technology;Therapeutic;therapeutic effectiveness;Therapeutic Uses;Time;translational potential;Treatment outcome;Tremor;United States;verbal;Vestibule;vibration;vocal cord;Voice;Voice Quality

PROJECT_TITLE: Effects of deep brain stimulation (DBS) on laryngeal function and associated behaviors in Parkinson Disease

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Pediatric;Pediatric Cardiomyopathy;Racial and Ethnic Minority Health Research;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Hypertrophic cardiomyopathy is the most common heritable cardiac disease and is the most common cause of sudden cardiac death in young adults. This project proposes to combine patient clinical and biomarker data with powerful in vitro tools of induced pluripotent stem cell (iPSC) technology, genome editing and tissue engineering, to gain important insights and understanding of potential triggers and molecular pathways involved in hypertrophic cardiomyopathy in Black individuals. Our ultimate goal is to improve patient care and patient quality of life in those who have this disease.

PI_NAMEs: CRESCI, SHARON  (contact)

PROGRAM_OFFICER_NAME: KETEMA, FASSIL

PROJECT_TERMS: Adult;adverse outcome;Age;Arrhythmia;Biological Assay;Biological Markers;Biological Models;black patient;Black Populations;Black race;Cardiac;Cardiac Myocytes;cardiac tissue engineering;cardiogenesis;Cessation of life;Clinical;Clinical Data;cohort;course development;Data;Development;Diagnosis;Disease;disease-causing mutation;Disparity;Disparity in diagnosis;Echocardiography;Electrocardiogram;Electrophysiology (science);Exhibits;Fibrosis;Functional disorder;Genetic;genetic testing;genetic variant;genome editing;Genotype;Goals;Health Status;Heart;Heart Diseases;Heart failure;Heritability;Hospitalization;human induced pluripotent stem cells;Hypertension;Hypertrophic Cardiomyopathy;Hypertrophy;Implantable Defibrillators;improved;In Vitro;in vitro Model;Individual;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;induced pluripotent stem cell technology;insight;Intervention;Left Ventricular Ejection Fraction;Left Ventricular Hypertrophy;Mechanics;Medical Genetics;miniaturize;Modeling;Molecular;mortality;mouse model;Mutation;Myocardium;novel;Outcome;Pathogenicity;Pathway interactions;Patient Care;Patient-Focused Outcomes;Patients;peer;Phenotype;Physicians;Physiology;Plasma;Population;Predisposition;pressure;Proteomics;Quality of life;racial disparity;research clinical testing;Research Personnel;Resistance;Rest;Risk;Risk Factors;risk stratification;Sarcomeres;sudden cardiac death;Tissue Engineering;tool;Variant;variant of interest;variant of unknown significance;young adult

PROJECT_TITLE: Determining Potential Mechanisms of Worse Outcomes in Black HCM Patients

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

ORG_STATE: NY

PHR: ANIMAL & TISSUE IMAGING SHARED RESOURCE- PROJECT NARRATIVE Not required per PAR-20-043

PI_NAMEs: TROTMAN, LLOYD C (contact)

PROJECT_TERMS: 3-Dimensional;Anatomy;Animal Cancer Model;animal imaging;Animals;anti-cancer research;bioluminescence imaging;Cancer Biology;Cancer Center;Cancer Center at Cold Spring Harbor Laboratory;Cancer Center Support Grant;Cancer Diagnostics;cancer imaging;Cancer Model;Cell Survival;Color;cryostat;Data Analyses;Development;Disease;Doctor of Philosophy;Dose;drug sensitivity;Education;Educational workshop;Equipment;Evaluation;ex vivo imaging;experience;Experimental Designs;Faculty;fluorescence imaging;Funding;Future;Gamma counter;Goals;Head;Histologic;Histology;Human;Image;Image Analysis;imager;imaging approach;imaging modality;Imaging Techniques;Immunofluorescence Immunologic;Immunohistochemistry;ImmunoPET;In Situ Hybridization;in vivo;in vivo imaging;Individual;innovation;instrument;instrumentation;interest;Ionizing radiation;lectures;Lesion;Measures;member;Methods;Mission;Modality;Molecular;Mus;Neoplasm Metastasis;neoplastic cell;non-invasive imaging;novel;novel diagnostics;novel therapeutic intervention;optical imaging;Optics;Pathology;PET/CT scan;Physiological;Positron-Emission Tomography;pre-clinical;Preparation;Primary Neoplasm;Printing;Publications;Reagent;Reporter;Research;Research Personnel;Research Project Grants;Resolution;Resource Sharing;Resources;response;Sampling;Scanning;Services;single photon emission computed tomography;Slide;Stains;Students;Surveys;Teacher Professional Development;Technology;Tissue imaging;Tissue Microarray;tissue preparation;tissue processing;tool;Training;tumor;Tumor Biology;tumor heterogeneity;tumor microenvironment;Tumor Tissue;Ultrasonography;ultrasound;user-friendly

PROJECT_TITLE: Animal & Tissue Imaging Shared Resource

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunization;Stem Cell Research;Stem Cell Research - Embryonic - Human

PHR: ANTIBODY & PHAGE DISPLAY SHARED RESOURCE – PROJECT NARRATIVE Not required per PAR-20-043

PI_NAMEs: KRAINER, ADRIAN R (contact)

PROJECT_TERMS: Address;Affinity;Alpaca;Animals;anti-cancer research;Antibodies;Antibody Affinity;antibody engineering;Antibody Formation;Area;B-Lymphocytes;Binding;Biological Assay;Biological Markers;Biotechnology;Bispecific Antibodies;Cancer Biology;Cancer Center;Cancer Center at Cold Spring Harbor Laboratory;Cancer Center Support Grant;cell immortalization;Cell Line;Cell Separation;Cell Surface Proteins;Cells;Cloning;Collaborations;Consultations;cost effectiveness;design;Development;Diagnostic;differential expression;Disease;Doctor of Philosophy;Engineering;Epitope Mapping;Epitopes;Experimental Designs;experimental study;Faculty;Funding;Generations;Genomics;Goals;Head;humanized antibody;Hybridomas;Immune;Immunization;Immunize;improved;Individual;innovation;Investigational Therapies;Laminin;Libraries;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;member;Methods;Molecular Cloning;nanobodies;Nature;novel;Phage Display;Plasmids;Play;Post-Translational Protein Processing;pre-clinical;Procedures;Process;Production;programs;Property;protein expression;Proteoglycan;Protocols documentation;Publications;Reagent;Receptor Signaling;Research;Research Personnel;Resource Sharing;Resources;response;Rodent;Role;Sampling;Science;Scientist;Services;single cell analysis;Spleen;Surface;Techniques;Technology;Testing;Therapeutic;Therapeutic antibodies;Tissues;tool;Translating;tumor;tumor microenvironment;tumorigenesis;Validation;vector;Work;Yeasts

PROJECT_TITLE: Antibody & Phage Display Shared Resource


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Bioengineering;Cardiovascular

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Public Health Relevance Statement (Project Narrative) The Caltech/UCLA integrated Cardiovascular Medicine for Bioengineers (iCMB) embraces a humanistic approach to integrate training in imaging or sensing coupled with machine learning to confront the rising endemic of cardiometabolic disease. The joint mentorship with the biomedical faculty alongside with engineering or industry partnership provides an interactive ecosystem for recruiting and retaining our under- represented iCMB scholars. The vision is to accelerate innovation to commercialization via pathways in advanced skills in clinical research design, ethics of human research, and scientific communication as the next generation of leaders in cardiovascular engineering.

PI_NAMEs: HSIAI, TZUNG K (contact);PAJUKANTA, PAIVI ;TAI, YU-CHONG

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TITLE: UCLA and Caltech integrated Cardiovascular Medicine for Bioengineers (iCMB)

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Neurosciences;Nutrition;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: CINCINNATI

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Narrative Survivors of childhood cancer often report problems with working memory and executive function (attention, planning) as adolescents and extending in to adulthood. Experiments in this proposal will use a mouse model of cancer plus chemotherapy in early life to better understand how the brain is negatively affected, and to start to identify new therapies to improve cognitive side effects in childhood cancer survivors.

PI_NAMEs: REYES, TERESA M (contact)

PROGRAM_OFFICER_NAME: SEAY, JULIA SUSAN

PROJECT_TERMS: 5 year old;Acute Lymphocytic Leukemia;Adolescence;Adolescent;Adult;Affect;Aftercare;antagonist;Antioxidants;Area;Attention;Automobile Driving;Brain;Cancer Model;CCL2 gene;cell growth;Cell Line;Cells;Cerebrospinal Fluid;chemotherapeutic agent;chemotherapy;Chemotherapy-Oncologic Procedure;Child;Childhood;childhood cancer survivor;Childhood Leukemia;Cognitive;Cognitive deficits;cognitive function;CSF1R gene;Development;dietary;Dietary Intervention;Executive Dysfunction;executive function;experimental study;Exposure to;flexibility;Folic Acid;folic acid metabolism;Gene Expression Profile;Genes;Genetic Transcription;gray matter;Homocysteine;Immune;Impaired cognition;improved;Inflammation;Inflammatory;Interleukin-1;Interleukin-1 Receptors;Interruption;Intervention;ITGAM gene;Leucovorin;leukemia;Leukemic Cell;Life;Link;Macrophage-1 Antigen;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;Memory impairment;Methotrexate;Microglia;mouse model;Mus;myelination;N-Acetylcysteinamide;neuroinflammation;novel therapeutics;Outcome;Oxidative Stress;Pathway interactions;Patients;Phagocytes;Pharmaceutical Preparations;Plasma;postnatal;Prefrontal Cortex;Quality of life;reduce symptoms;Reporting;response;Risk;Role;Short-Term Memory;side effect;single-cell RNA sequencing;Solid;Source;standard of care;Supplementation;Survival Rate;Survivors;Synapses;synaptic function;synaptic pruning;synaptogenesis;Testing;Therapeutic;therapy development;Time;Vincristine;Vitamin B Complex;white matter;white matter damage;young adult

PROJECT_TITLE: Identification of causal factors underlying cognitive deficits in a mouse model of childhood leukemia survival


NIH_SPENDING_CATS: Cancer;Stem Cell Research;Stem Cell Research - Embryonic - Human

PHR: FLOW CYTOMETRY SHARED RESOURCE – PROJECT NARRATIVE Not required per PAR-20-043

PI_NAMEs: FEARON, DOUGLAS T (contact)

PROJECT_TERMS: Acceleration;Accounting;Aneuploidy;Animal Model;anti-cancer research;Apoptosis;cancer cell;Cancer Center;Cancer Center Support Grant;cell analyzer;Cell Cycle Progression;Cell Separation;cell type;Cells;Cellular biology;Collaborations;Complement;Computer software;computerized data processing;Consultations;Continuing Education;Data;data acquisition;Data Analyses;design;Doctor of Medicine;Ensure;Equipment;Experimental Designs;Faculty;flexibility;Flow Cytometry;Flow Cytometry Shared Resource;Fluorescent Antibody Technique;Fluorochrome;Funding;Generations;Grant;Head;Immune;Individual;innovation;instrument;instrumentation;interest;investigator training;Laboratories;Lasers;Malignant Neoplasms;member;Modality;Newsletter;operation;Phenotype;Ploidies;Population;Population Analysis;Preparation;Printing;programs;protocol development;Publications;Recovery;Research;Research Personnel;Research Support;Resource Sharing;response;Role;Running;Sampling;service utilization;Services;single cell analysis;single cell sequencing;Sorting;stem cells;Techniques;Training;Tube;user-friendly

PROJECT_TITLE: Flow Cytometry Shared Resource


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Chronic Obstructive Pulmonary Disease;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: FREDERICK

ORG_NAME: AKONNI BIOSYSTEMS, INC.

ORG_STATE: MD

PHR: PROJECT NARRATIVE Mycobacteria that cause respiratory infections, such as nontuberculous mycobacteria lung disease, require many months and tens of thousands of dollars for treatment. The diagnostic algorithm to identify (or rule out) the organism that is the cause of the infection (and detect drug resistance), is complex because of a lack of a comprehensive, sensitive and rapid test. We propose to develop a molecular test that identifies clinically- relevant mycobacteria species and sub-species that cause respiratory infections and detects genetic mutations that confer drug-resistance.

PI_NAMEs: COONEY, CHRISTOPHER GERARD (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Academy;Acid Fast Bacillae Staining Method;Address;Algorithms;American;Aminoglycoside resistance;Anti-microbial susceptibility;Antibiotics;Antimicrobial Resistance;automated analysis;Azithromycin;Bacillus;Bacteria;Biological Assay;Bronchiectasis;Cause of Death;Chronic;Chronic Obstructive Pulmonary Disease;Clarithromycin;Clinic;Clinical;clinical diagnosis;Clinical Microbiology;Clinical Research;clinically relevant;Collaborations;Combination Drug Therapy;Companions;Complex;Computer software;Consumption;Detection;Development;Diagnosis;Diagnostic;diagnostic algorithm;Diagnostic tests;Disease;DNA;DNA Sequence Alteration;Drug resistance;drug testing;editorial;Elements;Erythromycin;Etiology;Film;follower of religion Jewish;Freeze Drying;General Population;Genes;Genetic Polymorphism;Genomics;Genus Mycobacterium;Glass;Goals;Health;imager;Incidence;Individual;Infection;instrument;Journals;Laboratories;Laboratory Diagnosis;Laboratory Study;Life;Liquid substance;Low Prevalence;Lung Diseases;Lung infections;Macrolide-resistance;Magnetism;member;Methodology;Methyltransferase;Microbe;Microbial Biofilms;Microbiology;Microfluidics;Molecular;Molecular Diagnostic Testing;mycobacterial;Mycobacterium abscessus;Mycobacterium avium Complex;Mycobacterium Infections;Mycobacterium tuberculosis complex;new epidemic;non-tuberculosis mycobacteria;novel therapeutics;Nucleic Acids;optimal treatments;Organism;Patients;Performance;Pharmaceutical Preparations;Phase;Phenotype;Point Mutation;Polymorphism Analysis;Porosity;portability;Positioning Attribute;Prevalence;Process;Protocols documentation;Pulmonary Emphysema;Pulmonary Tuberculosis;radiological imaging;rapid test;Reagent;Regimen;Relapse;Resistance;Resistance to infection;respiratory;Respiratory Tract Infections;Ribosomes;Risk Factors;Robotics;Rotation;rRNA Genes;Sampling;Sensitivity and Specificity;Soil;Specificity;Specimen;Sputum;Step Tests;test strip;Testing;Time;Tuberculosis;tuberculosis treatment;Veterans;virtual;Viscosity;Water;working group

PROJECT_TITLE: Lab-on-a-Film Multiplexed Test for Respiratory Mycobacterial Infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-V(13)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury;Urologic Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Narrative This is a renewal of an international collaboration to study the soluble guanylate cyclase (sGC) activator, BAY 58-2667 (cinaciguat), in treating bladder afferent sensitization and detrusor overactivity due to micromotion. Using C57BL/6 mice of both sexes with acrolein-induced cystitis or T8-T9 spinal cord transection (SCT) we have demonstrated improved bladder function whilst overcoming reliance on nitric oxide (NO•) due to nitrergic nerve damage and decreased NO• production or oxidative stress and inactivation of sGC. The University of Pittsburgh team will use in vivo and in vitro approaches to study peripheral LUT functions and the University of Bristol group, an in situ decerebrate arterially perfused mouse (DAPM) to study centrally mediated LUT reflexes. Since cinaciguat has passed phase 1 safety trials for non-urological pathologies, the proposed studies have considerable clinical relevance and translational potential.

PI_NAMEs: BIRDER, LORI A;KANAI, ANTHONY JOHN (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Acrolein;Address;Affect;afferent nerve;Agonist;analog;ANK1 gene;Behavior;Binding;Bladder;Bladder Dysfunction;C57BL/6 Mouse;cell type;Clinical;Clinical effectiveness;clinical translation;clinically relevant;cognitive function;Collaborations;Combined Modality Therapy;Cyclic GMP;Cyclic GMP-Dependent Protein Kinases;Cystitis;cytochrome b5 reductase;Data;Decerebration procedure;Efferent Neurons;Event;Functional disorder;Guanosine Triphosphate;Heme;Heme Group;Human;improved;In Situ;In Vitro;in vivo;inhibitor;International;interstitial cell;intravesical;Intravesical Instillation;Knockout Mice;Lower urinary tract;lower urinary tract symptoms;Mediating;Micturition Reflex;Motion;Motor;mouse model;Mus;NADP;Nerve;nerve damage;Neurogenic Bladder;Neurons;Neuropathy;Nitric Oxide;Nitroxidergic Nerves;Oxidative Stress;Pathology;Pathway interactions;Patients;Perfusion;Peripheral;Phase;phosphoric diester hydrolase;Physiological;Production;receptor;Reflex action;Refractory;Relaxation;response;Safety;Sensory;sex;Signal Transduction;sildenafil;Smooth Muscle;Soluble Guanylate Cyclase;Spinal Cord transection injury;Stretching;tadalafil;Therapeutic;Tissues;translational potential;TRPA channel;Universities;Urothelial Cell;Urothelium

PROJECT_TITLE: PDE5 Inhibition of Afferents and Interstitial Cells in Overactive Mouse Bladders

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-B(90)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Orphan Drug;Pancreatic Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

PHR: FUNCTIONAL GENOMICS SHARED RESOURCE– PROJECT NARRATIVE Not required per PAR-20-043

PI_NAMEs: VAKOC, CHRISTOPHER  (contact)

PROJECT_TERMS: Breast;Cancer Center;Cancer Center Support Grant;cancer therapy;Cell Culture Techniques;Cloning Vectors;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Collection;Colon;CRISPR library;CRISPR screen;Custom;Data Analyses;Dependence;design;Development;Disease;Doctor of Medicine;Doctor of Philosophy;Eligibility Determination;Endometrial;Equipment;experience;experimental study;Faculty;fluorescence microscope;functional genomics;Funding;Future;gene discovery;Gene Family;Generations;Genes;Genetic;Genetic Screening;genome editing;genome-wide;genomic tools;Genomics;Genomics Shared Resource;Goals;Grant;Head;Health;Human;improved;In Vitro;in vivo;Incubators;innovation;insight;Institution;Laboratories;Libraries;Malignant Neoplasms;Mammalian Cell;matrigel;member;Methodology;Modeling;Modification;Mus;new therapeutic target;novel;Oncogenes;Organoids;Pancreatic Ductal Adenocarcinoma;paralogous gene;Pathway interactions;Patients;Play;Production;programs;promoter;Publications;Reader;Reagent;Research;Research Personnel;Research Project Grants;Resource Sharing;response;RNA Interference;RNA interference screen;Role;Scientist;screening;Services;small hairpin RNA;System;Technology;Therapeutic;therapeutic target;Time;Tissues;tool;Training;vector;Vertebral column

PROJECT_TITLE: Functional Genomics Shared Resource


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Stem Cell Research;Stem Cell Research - Embryonic - Human

PHR: MASS SPECTROMETRY– PROJECT NARRATIVE Not required per PAR-20-043

PI_NAMEs: PAPPIN, DARRYL J (contact)

PROJECT_TERMS: Acceleration;Accounting;Address;anti-cancer research;Binding;Biological;Biological Assay;Blood capillaries;CA-19-9 Antigen;Cancer Center;Cancer Center at Cold Spring Harbor Laboratory;Cancer Center Support Grant;Carbohydrates;Chelating Agents;Chemicals;collaborative environment;community center;Computers;Copper;Crystallography;Cysteine;Data;Data Analyses;Development;Devices;DNA;Doctor of Philosophy;Drug Kinetics;Educational workshop;Equipment;Experimental Designs;experimental study;Faculty;Floor;Funding;Future;Gel;Goals;Head;High Pressure Liquid Chromatography;hydrophilicity;Hydrophobicity;Individual;innovation;Institution;instrument;instrumentation;Investigation;Label;Laboratories;large datasets;lectures;lipidomics;Lipids;Liquid Chromatography;Malignant neoplasm of pancreas;Malignant Neoplasms;mass spectrometer;mass spectrometry shared resource;Mass Spectrum Analysis;Measurement;member;Metabolic Pathway;metabolomics;method development;Methods;Mission;novel;Organelles;pancreatic secretory trypsin inhibitor I;Pancreatitis;Pharmaceutical Preparations;phosphoproteomics;Polysaccharides;Post-Translational Protein Processing;Preparation;Printing;programs;protein complex;protein profiling;Proteins;Proteome;Proteomics;Protocols documentation;Publications;Reaction;recruit;Research;Research Personnel;Resources;RNA;Sampling;Services;small molecule;stable isotope;structural biology;Students;success;System;Teacher Professional Development;Technical Expertise;Techniques;Technology;Time;Tissues;tool;Transcend;ultra high pressure;Update;Work

PROJECT_TITLE: Mass Spectrometry Shared Resource


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Prevention;Serious Mental Illness;Social Determinants of Health;Women's Health Research

ORG_CITY: EAST LANSING

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative Postpartum depression is a common and impactful public health problem, which has severe and lasting consequences for the mother and infant, and sometimes the entire family. The Reach Out, Stand Strong, Essentials for New Mothers (ROSE) program is an evidence-based intervention that prevents half of cases of postpartum depression and was one of two interventions recommended by the US Preventive Services Task Force in 2019. This project is the first fully-powered randomized control trial to assess whether all pregnant women or only those at risk for postpartum depression should receive an evidence-based intervention (ROSE) for preventing postpartum depression cases. This project will help ensure that those who need postpartum depression prevention receive it.

PI_NAMEs: JOHNSON, JENNIFER E (contact);ZLOTNICK, CARON

PROGRAM_OFFICER_NAME: CHU, SERENA PO-LAN

PROJECT_TERMS: Address;Adult;Birth;Clinic;Communities;community setting;cost;cost outcomes;Counseling;Data;Decision Making;depression prevention;depressive symptoms;Effectiveness;effectiveness evaluation;effectiveness trial;Electronic Health Record;enhanced care;Enrollment;Ensure;Equity;ethnic diversity;ethnic minority;evidence base;Evidence based intervention;Evidence based program;Face;Family;flexibility;functional improvement;General Population;health care settings;Health system;Healthcare;High Risk Woman;Home visitation;implementation barriers;implementation facilitators;implementation strategy;implementation study;implementation trial;Incidence;indicated prevention;Individual;Infant;Intervention;Interview;Judgment;Licensing;Low income;Measures;Medicaid;Mental Health;Minority;Minority Status;Mothers;Names;Not Hispanic or Latino;novel;Outcome;Perinatal Care;peripartum depression;Persons;Postpartum Depression;Pregnancy;pregnant;Pregnant Women;prenatal;Prenatal care;prevent;Prevention;Prevention approach;Prevention trial;preventive intervention;Process;programs;Provider;Public Health;racial diversity;racial minority;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;relative effectiveness;Reporting;Risk;Risk Assessment;Risk Factors;Sampling;scale up;screening;Screening procedure;selective prevention;Services;single episode major depressive disorder;social stigma;Stigmatization;Structure;Surveys;Testing;Time;tool;Training;treatment as usual;trial enrollment;United States Preventative Services Task Force;universal prevention;White Women;Woman;Work

PROJECT_TITLE: The ROSE Scale-Up Study: Informing a decision about ROSE as universal postpartum depression prevention


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

ORG_CITY: BOSTON

ORG_NAME: BOSTON MEDICAL CENTER

ORG_STATE: MA

PHR: NARRATIVE The International Uganda Russia Boston Alcohol Network for Alcohol Research Collaboration on HIV/AIDS (URBAN ARCH) Center will generate new generalizable knowledge about the complex relationship between TB, HIV, and alcohol use in order to accelerate the future development of interventions that can reduce alcohol’s impact on TB-related morbidity and mortality among PLWH.

PI_NAMEs: SAMET, JEFFREY H. (contact)

PROGRAM_OFFICER_NAME: LIN, LI

PROJECT_TERMS: Acceleration;Accounting;active method;acute coronary syndrome;Address;Aftercare;Alcohol consumption;alcohol intervention;alcohol research;Alcohols;Automobile Driving;Bacillus;Biometry;Boston;career;Cause of Death;Cessation of life;Clinical;co-infection;cohort;Collaborations;comorbidity;Complex;Data;data management;Data Management Resources;design;Disease;Ensure;Epidemic;experience;Fostering;Future;Goals;Heavy Drinking;high risk;HIV;HIV/AIDS;HIV/TB;Immunosuppression;Impairment;improved;Individual;Infectious Agent;innovation;International;Intervention;isoniazid;Knowledge;Lung;Lung Diseases;lung health;Malignant neoplasm of lung;Measures;Mentors;Morbidity - disease rate;mortality;mortality risk;multidisciplinary;Mycobacterium tuberculosis;NIH Office of AIDS Research;Outcome;Persons;Population;Predisposition;prevent;Prevention;Preventive therapy;Productivity;Pulmonary Tuberculosis;Recording of previous events;Research;Research Personnel;Research Project Grants;Rifampin;rifapentine;Risk;Risk Reduction;Role;Russia;smoking intervention;Statistical Data Interpretation;Structure;Testing;therapy development;Training;Tuberculosis;tuberculosis treatment;Uganda;Work

PROJECT_TITLE: The International URBAN Alcohol Research Collaboration on HIV/AIDS (ARCH) Center


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biodefense and Related Countermeasures;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Prevention;Rare Diseases;Substance Misuse;Tuberculosis

PROJECT_TERMS: Acceleration;Accounting;active method;addiction;Address;Affect;Aftercare;alcohol consequences;Alcohol consumption;alcohol intervention;alcohol research;alcohol risk;Alcohols;Automobile Driving;Biometry;Bone Density;career;Cause of Death;CD4 Lymphocyte Count;Cessation of life;co-infection;cohort;Collaborations;Communicable Diseases;Communication;comorbidity;Complex;Data;data management;Data Management Resources;data sharing;Disease;Ensure;Epidemiology;experience;Fostering;frailty;Future;Goals;Heavy Drinking;HIV;HIV Infections;HIV/AIDS;Infectious Agent;inflammatory marker;innovation;Internal Medicine;International;International Aspects;Intervention;Knowledge;Leadership;Location;Lung Diseases;Medicine;Mentors;Morbidity - disease rate;mortality;multidisciplinary;next generation;NIH Office of AIDS Research;Persons;Preventive treatment;Principal Investigator;Pulmonary Tuberculosis;Pulmonology;repository;Research;Research Personnel;Research Project Grants;Resources;Risk;Risk Factors;Risk Reduction;Role;Russia;Sampling;Smoking;smoking intervention;Statistical Data Interpretation;success;synergism;therapy development;Training;Tuberculosis;tuberculosis treatment;Uganda;United States;Zinc

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Cancer;Stem Cell Research;Stem Cell Research - Embryonic - Human

PHR: MICROSCOPY SHARED RESOURCE – PROJECT NARRATIVE Not required per PAR-20-043

PI_NAMEs: SPECTOR, DAVID L (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;anti-cancer research;Antibodies;Biological;cancer cell;Cancer Center;Cancer Center Support Grant;Cell Differentiation process;Cell Fractionation;cell preparation;Cells;Chromosome Segregation;Complement;Computer software;Confocal Microscopy;Consultations;Data;DNA;Doctor of Philosophy;Electron Microscope;Electron Microscopy;Electrons;Ensure;Equipment;Evaluation;experience;Experimental Designs;experimental study;Faculty;Fluorescence;Fluorescence Microscopy;Funding;Future;Head;high resolution imaging;Image;image processing;imaging approach;Imaging technology;Immunoelectron Microscopy;Immunofluorescence Immunologic;Immunofluorescence Microscopy;Individual;insight;instrument;instrumentation;Laboratories;Laser Scanning Confocal Microscopy;Learning;Light;Lighting;live cell imaging;Maintenance;Measurement;member;Microscope;Microscopic;Microscopy;Microtomy;Modality;molecular imaging;Monitor;Negative Staining;neoplastic cell;novel;Nucleic Acids;operation;Organelles;Organoids;Postdoctoral Fellow;Preparation;Procedures;Process;programs;Proteins;Protocols documentation;Publications;Quantitative Microscopy;quantum;recruit;Research;Research Personnel;Resolution;Resource Sharing;Resources;restoration;Retirement;Sampling;Science;Services;Signal Transduction;single molecule;Specimen;Structure;Subcellular structure;superresolution imaging;superresolution microscopy;System;Technical Expertise;Time;Tissues;Training;Transmission Electron Microscopy;treatment response;tumor;ultra high resolution;Update;Visualization

PROJECT_TITLE: Microscopy Shared Resource


NIH_SPENDING_CATS: Cancer;Clinical Research;Stem Cell Research;Stem Cell Research - Embryonic - Human

PHR: ORGANOID SHARED RESOURCE – PROJECT NARRATIVE Not required per PAR-20-043

PI_NAMEs: DOS SANTOS, CAMILA  (contact)

PROJECT_TERMS: 3-Dimensional;American Type Culture Collection;Anatomy;Basic Science;biobank;Biological Models;Biological Process;Cancer Center;Cancer Center Support Grant;cancer health disparity;Cancer Model;cancer type;Cell Line;Cells;Chemicals;Communities;Consultations;Contracts;cost;Cost Savings;Dedications;Development;Diagnostic;diagnostic development;Doctor of Philosophy;drug development;Drug Modelings;Education;Ensure;Equipment;experience;experimental study;Faculty;Fostering;Funding;Generations;Head;Health;Human;human tissue;Image;Institution;instrumentation;Laboratories;Licensing;Link;Malignant Neoplasms;member;Methods;Modeling;Molecular;Mus;neoplastic;operation;Organoids;Patients;Population Heterogeneity;Primary Neoplasm;Printing;programs;protocol development;Protocols documentation;Publications;Reagent;Research;Research Personnel;Resource Sharing;Resources;Standardization;Technology;three dimensional cell culture;Tissue Banks;Tissue Sample;Training;Translational Research;tumor;Tumor Biology;tumor progression;two-dimensional;Work

PROJECT_TITLE: Organoid Shared Resource


ADMINISTERING_IC: NS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: ITHACA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative  Imaging the structure and function of intact brains over a large depth and 3-dimensional volume, with high spatial and temporal resolution, is key to understand how the brain works. We will build a new laser and microscope that will improve deep brain imaging by more than a factor of 10 in imaging volume or speed. We will demonstrate the applicability of the system in three key neuroscience problems and provide a path to the commercialization and dissemination of the technology.

PI_NAMEs: XU, CHRIS  (contact)

PROGRAM_OFFICER_NAME: PUCAK, MICHELE LYNN

PROJECT_TERMS: 3-Dimensional;Amplifiers;Animal Model;Behavior;Brain;Brain imaging;brain tissue;Budgets;Calcium;cell type;Chronic;commercialization;Cortical Column;Data;design;Detection;Development;equity, diversity, and inclusion;experimental study;feeding;Fiber;Fluorescence;fly;Frequencies;Gases;Generations;Genetic;Goals;Image;Imaging Device;imaging software;Imaging technology;improved;in vivo;in vivo imaging;industry partner;innovation;Institution;interest;Lasers;Measurement;member;Methods;Microscope;multi-photon;multiphoton imaging;multiphoton microscopy;Mus;Nervous System;neural;Neurons;Neurosciences;Noise;novel strategies;optical imaging;Optics;outreach;Penetration;Performance;Photons;Physiologic pulse;Population;Process;programs;Pulse Rates;Research;Research Personnel;Research Proposals;Resolution;Resource Sharing;Sampling;Scanning;second harmonic;Signal Transduction;Site;Source;Speed;Structure;Synapses;System;Technology;temporal measurement;Testing;three photon microscopy;timeline;Tissue imaging;Tissues;Training;Trees;trend;two photon microscopy;two-photon;voltage;Work

PROJECT_TITLE: Deep and Fast Imaging Using Adaptive Excitation Sources


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Prevention;Rare Diseases;Substance Misuse;Tuberculosis

PI_NAMEs: CHENG, DEBBIE M. (contact)

PROJECT_TERMS: Acceleration;Address;Alcohol consumption;alcohol research;Alcohols;archive data;Biometry;Clinical;Collaborations;Collection;Communication;cost effective;Data;data archive;Data Collection;data management;Data Management Resources;data quality;data sharing;Dedications;design;Disease;Ensure;experience;Faculty;Formulation;Foundations;Future;Goals;Grant;high standard;HIV;HIV/AIDS;HIV/TB;innovation;International;Knowledge;Leadership;Lung Diseases;Manuscripts;Methods;Mission;Monitor;Morbidity - disease rate;mortality;Outcome Measure;Persons;Phase;Play;Preparation;Procedures;Productivity;Publications;Pulmonary Tuberculosis;Qualifying;Recording of previous events;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Resources;Role;Secure;sound;Statistical Data Interpretation;Surveys;synergism;Techniques;therapy development;Training;Tuberculosis;tuberculosis treatment;Uganda;Work

PROJECT_TITLE: Biostatistics and Data Management Resource Core


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Obesity;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Mental Health;Mental Illness;Neurosciences;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Serious Mental Illness;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Only 5% of young children receive mental health care, as most do not exhibit obvious psychiatric behavioral symptoms before age 2 or, more commonly, school age. The overall goals of this program are to 1) identify common biological and brain-based pathways by which prenatal exposures exert their influence on offspring and confer psychiatric risk; and 2) to train the next generation of patient-oriented scientists interested in perinatal- developmental neuroscience.

PI_NAMEs: SPANN, MARISA N (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: advanced analytics;Age;analytical method;antepartum depression;Anterior;Anxiety;Area;Attention;Autoimmune Diseases;Behavior Therapy;Behavioral;Behavioral Symptoms;Biological;Biological Markers;Blood Glucose;Body mass index;Brain;brain based;brain morphology;brain pathway;Brain region;brain volume;career;career development;career networking;Child;Childhood;cingulate cortex;Cognitive;cohort;Computerized Medical Record;Data;Data Collection;Data Pooling;Data Set;Development;diabetes risk;Diagnosis;Dimensions;Distress;Dorsal;Early Diagnosis;Early identification;Ensure;environmental stressor;experience;fetal;Funding;Funding Mechanisms;Future;Goals;Health;Health education;health information technology;High Prevalence;human model;Hydrocortisone;hypothalamic-pituitary-adrenal axis;Image;Immune system;improved;indexing;Infant;Infection;Inflammation;Insula of Reil;interest;intergenerational;International;Intervention;Knowledge;Laboratories;Life Style;Link;Literature;Magnetic Resonance Imaging;Manuscripts;Maps;maternal depression;Medial;Mediating;Medical center;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Mentors;Mentorship;Midcareer Investigator Award in Patient-Oriented Research;Mothers;National Institute of Child Health and Human Development;National Institute of Mental Health;Neonatal;Neurobiology;neuroimaging;Neurosciences;next generation;Obesity;obesity risk;offspring;Outcome;Pathway interactions;patient oriented;patient oriented research;patient population;Perinatal;personalized approach;Pilot Projects;Positioning Attribute;Prefrontal Cortex;Pregnancy;Pregnant Women;prenatal;prenatal exposure;prenatal health;prenatal influence;Procedures;Productivity;Program Development;programs;psychiatric symptom;psychological distress;psychological stressor;Public Health;Regulation;Research;Research Domain Criteria;Research Personnel;research study;Research Training;Resources;Risk;Rodent Model;Role;Salivary;Sampling;School-Age Population;Science;Scientist;Series;skills;socioeconomics;Stress;Structure;success;Symptoms;Thalamic structure;Toddler;Training;Training Activity;Training Programs;Training Support;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Midcareer investigator award in patient-oriented research in the area of perinatal-developmental neuroscience

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

PHR: SEQUENCING TECHNOLOGIES & ANALYSIS SHARED RESOURCE – PROJECT NARRATIVE Not required per PAR-20-043

PI_NAMEs: MCCOMBIE, WILLIAM RICHARD (contact)

PROJECT_TERMS: Address;analytical tool;anti-cancer research;ATAC-seq;Bioinformatics;bioinformatics resource;Biological Assay;Cancer Center;Cancer Center at Cold Spring Harbor Laboratory;Cancer Center Support Grant;cancer genome;ChIP-seq;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communities;computer infrastructure;Computer software;computerized tools;computing resources;Consultations;cost;cost effective;Custom;Data;Data Analyses;data mining;Data Set;design;Development;DNA;DNA methylation profiling;DNA Resequencing;DNA sequencing;Doctor of Philosophy;Drug resistance;Education;Ensure;epitranscriptome;Equipment;exome;Faculty;Funding;Galaxy;gene panel;Genes;Genome;genome sequencing;Genomics;Goals;High-Throughput Nucleotide Sequencing;improved;Individual;Infrastructure;insight;instrument;instrumentation;interest;Laboratories;Libraries;Malignant Neoplasms;member;Methodology;Methods;Modeling;Modification;Mollies;nanopore;Neoplasm Metastasis;novel;Nucleic Acids;Oncogenes;Organoids;Pathogenesis;Phenotype;Postdoctoral Fellow;Preparation;preservation;Printing;programs;Protocols documentation;Publications;repository;Research;Research Personnel;Resource Sharing;Resources;response;RNA;RNA immunoprecipitation sequencing;Role;sequencing platform;Services;single cell analysis;single cell sequencing;single-cell RNA sequencing;Specialist;Structure;student training;Technical Expertise;Techniques;Technology;Time;tool;Training;transcriptome;transcriptome sequencing;Variant;variant detection;Visualization;Work

PROJECT_TITLE: Sequencing Technologies & Analysis Shared Resource


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

PHR: SINGLE-CELL BIOLOGY SHARED RESOURCE – PROJECT NARRATIVE Not required per PAR-20-043

PI_NAMEs: GILLIS, JESSE  (contact)

PROJECT_TERMS: ATAC-seq;Bioinformatics;Cancer Center;Cancer Center at Cold Spring Harbor Laboratory;Cancer Center Support Grant;Capital;Cell Culture Techniques;Cell Nucleus;Cell Separation;cell type;Cells;Cellular biology;Communities;community center;Complex;computational pipelines;computerized data processing;Copy Number Polymorphism;Custom;Data;Data Analyses;Data Set;design;digital;Dissociation;Doctor of Philosophy;Educational workshop;Equipment;Evolution;Experimental Designs;Faculty;Gene Expression;Gene Expression Profiling;Generations;genomic data;Genomics;Genotype;Head;Heterogeneity;Hour;Human Resources;Immune response;Immunologic Receptors;Informatics;Investigation;Laboratories;Learning;Libraries;Lipids;Logistics;Malignant Neoplasms;Manuscripts;member;Mission;Mutation;novel;Population;Preparation;Process;programs;Proteins;proteogenomics;protocol development;Protocols documentation;Publications;Quality Control;Reagent;Research;Research Personnel;Resolution;Resource Sharing;Resources;Sampling;Services;Side;single cell analysis;single cell ATAC-seq;single cell genomics;single cell sequencing;Techniques;Technology;Tissues;tool;Training and Education;transcriptome;transcriptome sequencing;transcriptomic profiling;transcriptomics;tumor heterogeneity;tumor microenvironment;tumor progression;Work

PROJECT_TITLE: Single-Cell Biology Shared Resource


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Prevention;Rare Diseases;Substance Misuse;Tuberculosis

PI_NAMEs: HAHN, JUDITH ALISSA (contact)

PROJECT_TERMS: Adherence;Adult;Africa South of the Sahara;Age;Alcohol consumption;alcohol intervention;alcohol measurement;alcohol research;alcohol risk;Alcohols;antiretroviral therapy;Behavior Therapy;Biological Markers;Body mass index;Cause of Death;CD4 Positive T Lymphocytes;Cell Count;cigarette smoking;cofactor;cohort;Collaborations;Country;Crowding;Cutaneous Tuberculosis;Disease;drinking;Electronics;Enrollment;environmental tobacco smoke;environmental tobacco smoke exposure;follow-up;Future;Gender;Goals;Heavy Drinking;high risk;high risk drinking;high risk population;HIV;HIV/AIDS;HIV/TB;Household;Hypersensitivity skin testing;Immunity;Incidence;International;Intervention;Knowledge;low socioeconomic status;Measurement;Mediator;Morbidity - disease rate;mortality;Mycobacterium tuberculosis;Odds Ratio;Participant;Pathway interactions;Persons;Phase;phosphatidylethanol;Policies;Population;Positioning Attribute;Positive Test Result;prevent;Preventive therapy;programs;progression risk;prospective;Prospective Studies;Recommendation;reduced alcohol use;Research;Risk;Risk Estimate;Risk Reduction;Role;Sampling;scale up;screening;Smoking;Socioeconomic Status;Test Result;Testing;therapy adherence;Treatment outcome;Tuberculin Test;Tuberculosis;tuberculosis treatment;Uganda;Viral

PROJECT_TITLE: The Role of Alcohol Use in Incident TB Infection and Active TB Disease Among Persons Living with HIV


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Health Services;Mental Health;Patient Safety;Prevention

ORG_CITY: NEW HAVEN

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Mental health conditions increasingly present to general emergency department settings; these visits are associated with 1.7 million annual episodes of agitation, defined as excessive psychomotor activity leading to violent behavior and physical danger to staff and patients. Although regulatory bodies and experts emphasize early risk assessment and use of behavioral techniques before agitation occurs, prevention of agitation is limited by lack of knowledge regarding specific risk factors that predict the need for pre-emptive intervention and complex care delivery in the general emergency department. In this study, we will address these challenges by developing and testing an electronic health record-based clinical decision support tool to help clinicians appropriately invest resources for at-risk patients and prevent agitation from occurring.

PI_NAMEs: WONG, AMBROSE H (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Accident and Emergency department;acute care;Address;Aggressive behavior;Agitation;Award;Behavioral;Biometry;care delivery;career;Characteristics;Clinical;clinical center;clinical decision support;Clinical Decision Support Systems;clinical decision-making;clinical development;clinical predictive model;clinical research site;clinical trial implementation;Clinical Trials;cohort;Collection;comorbidity;Complex;Data;Dissemination and Implementation;Early Diagnosis;Early treatment;Education;Electronic Health Record;Emergency Department Physician;Emergency department visit;Emergency Medicine;emergency settings;Enrollment;Ensure;Environment;Environmental Risk Factor;Event;Face;feasibility testing;Goals;Harm Reduction;health record;Health Services Research;Health system;improved;Institution;Intervention;Interview;Investments;Knowledge;Laboratories;Lead;Medical;Mental disorders;Mental Health;Mental Health Services;Mentors;Methods;Modeling;Modification;National Institute of Mental Health;Outcome;Patient risk;patient safety;Patient-Focused Outcomes;Patients;Physical Restraint;pilot trial;Policies;Predictive Factor;preemptive intervention;prevent;Prevention;Process;Provider;Public Health Informatics;Qualitative Methods;Randomized;rapid diagnosis;Recommendation;Recording of previous events;Research;Research Activity;Resources;restraint;Risk;Risk Assessment;Risk Factors;risk prediction model;risk stratification;Safety;sedative;Self Efficacy;severe mental illness;skills;Sudden Death;support tools;Symptoms;System;Techniques;Technology;Testing;Time;tool;Training;Traumatic injury;usability;user centered design;Validation;Variant;Violence;Visit;Work

PROJECT_TITLE: Clinical Decision Support Tool to Assess Risk and Prevent Agitation Events

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_CITY: SEATTLE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Many biologically or clinically relevant species present at extremely low concentrations, sometimes down to a few copies. Despite their key functions and diagnostic roles, it has been difficult to analyze these species with existing analytical methods due to insufficient sensitivity, selectivity, speed, or high cost. To address this technical challenge, this project aims to harness the power of optical microscopy and bipolar microelectrode arrays to develop a low-cost and highly sensitive analytical platform for detecting and counting individual biological target species.

PI_NAMEs: ZHANG, BO  (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Address;Adsorption;amplification detection;analytical method;Biological;Biological Process;Biomedical Research;Blood;cancer biomarkers;Cell Extracts;charge coupled device camera;Chemicals;clinically relevant;cost;Coupled;design;detection platform;Development;Diagnosis;Diagnostic;Electrochemistry;Electrodes;Elements;exosome;experience;Film;Future;Geometry;indium tin oxide;Individual;innovation;innovative technologies;instrument;instrumentation;Knowledge;Label;Lead;Learning;Ligands;light transmission;Liquid substance;magnetic beads;magnetic field;Magnetism;Metals;meter;Methods;Microelectrodes;Microfabrication;Microscope;Microscopy;Microspheres;Mission;nanofabrication;nanoparticle;National Institute of General Medical Sciences;Nucleic Acids;operation;Optics;oxidation;Oxidation-Reduction;Oxygen;particle;parylene;Performance;Reaction;receptor;Research;response;Risk;Role;Saliva;sensor;Side;Signal Transduction;Silicon Dioxide;Speed;success;Surface;Testing;Tissue Extracts;tool;tumor;United States National Institutes of Health;Virus;voltage;Work

PROJECT_TITLE: A Bipolar Electrochemical Single Entity Bioanalyzer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-D(81)S]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Childhood Obesity;Clinical Research;Contraception/Reproduction;Endocrine Disruptors;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

PHR: Project Narrative Understanding the structural factors that contribute to food insecurity and its downstream impact on social, racial, and ethnic inequities in diet quality, environmental chemical exposures, and pregnancy complications is imperative for identifying early-life and modifiable risk factors to improve women’s and children’s cardiometabolic health.

PI_NAMEs: HACKER, MICHELE RENEE;JAMES-TODD, TAMARRA M;OKEN, EMILY  (contact)

PROGRAM_OFFICER_NAME: ZANETTI, KRISTA A

PROJECT_TERMS: Adult;Affect;Area;Behavior;Birth;black women;Blood Pressure;Boston;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;Characteristics;Chemical Exposure;Child;Child Health;Childhood;cohort;community advisory board;Conceptions;Data;Data Collection;data platform;depressive symptoms;Diet;Dietary Practices;early childhood;Early identification;early pregnancy;Eating;Endocrine Disruptors;Enrollment;environmental chemical exposure;Environmental Epidemiology;epidemiology study;Equity;ethnic disparity;Ethnic Origin;Exposure to;fast food;Fertility;Food;Food Contamination;food insecurity;food security;Future;Gestational Age;Gestational Diabetes;gestational weight gain;Goals;Health;Health Food;health inequalities;high body mass index;high risk;Hispanic Women;Hypertension;improved;Individual;Inequity;Inflammatory;Intake;Life;Life Cycle Stages;Link;Maternal and Child Health;Maternal complication;Measures;Metabolic;modifiable risk;Mothers;Neighborhoods;Not Hispanic or Latino;nutritional epidemiology;Obesity;offspring;Outcome;Participant;Patient Self-Report;people of color;Perinatal;Persons;Phenols;phthalates;Physiology;Policies;Pregnancy;Pregnancy Complications;pregnancy disorder;pregnant;Premature Birth;prenatal;Process;programs;Protocols documentation;Race;racial disparity;recruit;reproductive;retention rate;Risk;Risk Factors;Science;Site;social;social epidemiology;Social Work;socioeconomics;Spontaneous abortion;structural determinants;Time;toxicant;Translating;Urine;Weight;Woman

PROJECT_TITLE: Neighborhoods and health across the life course: Early life inequities in food insecurity, diet quality, and chemical exposures

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-S(50)R]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: PROJECT NARRATIVE Deep brain stimulation (DBS) effectively ameliorates motor symptoms in Parkinson’s disease (PD), however its mechanism of action remains unclear, limiting further optimization of therapeutic efficacy. This study aims to test how delivering burst DBS instead of continuous electrical stimulation can produce long-lasting motor recovery by probing the behavioral effects, and the electrophysiological effects on the pathological synchrony in the basal ganglia nuclei, at various disease stages. This investigation might add to our understanding of the motor dysfunction in PD, while also providing further insights to new interventions in treating patients with PD.

PI_NAMEs: NANIVADEKAR, SHRUTI  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Acceleration;acute symptom;adverse outcome;Affect;Animals;Attenuated;Basal Ganglia;battery replacement;Behavior;Behavioral;Biological Markers;Bradykinesia;Cell Nucleus;cell type;Clinical;clinical translation;Coupled;Data;Deep Brain Stimulation;Disease;Dopamine;Dopamine Receptor;Dose;effective therapy;Electric Stimulation;Electrophysiology (science);endopeduncular nucleus;experience;Fiber;Foundations;Frequencies;Ganglia;Globus Pallidus;Goals;Histology;Homeobox;Homologous Gene;Hour;Human;Immobilization;Implant;improved;In Vitro;in vitro Model;in vivo;in vivo evaluation;insight;Intervention;Investigation;Knowledge;Machine Learning;Methods;Modeling;Motor;motor disorder;motor recovery;motor symptom;mouse model;Movement;Movement Disorders;Mus;Nervous System Disorder;neural;neuromechanism;neuronal circuitry;Neurons;neuroregulation;Neurosciences;neurotransmission;non-motor symptom;optimal treatments;optogenetics;Parkinson Disease;parkinsonian rodent;Parvalbumins;Pathologic;Patients;Pattern;Persons;Pharmaceutical Preparations;Physiological;power consumption;preclinical study;Progressive Disease;Protocols documentation;Quality of life;Recovery;Research;Risk;Rodent;Role;side effect;signal processing;skills;standard of care;Stimulus;Structure of subthalamic nucleus;Substantia nigra structure;symptom treatment;Symptoms;Synapses;Testing;Therapeutic;Time;Translations;Treatment Efficacy;Tremor;Work

PROJECT_TITLE: Cell-type Specific Neuromodulation Using Burst DBS Produces Long-lasting Behavioral and Physiological Rescue in a Parkinsonian Mouse Model


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Prevention;Rare Diseases;Substance Misuse;Tobacco;Tobacco Smoke and Health;Tuberculosis

PI_NAMEs: SO-ARMAH, KAKU  (contact)

PROJECT_TERMS: active method;Address;Aftercare;Alcohol abuse;Alcohol consumption;alcohol effect;alcohol intervention;alcohol research;alcohol use disorder;Alcohols;Anatomy;Back;Behavioral;behavioral pharmacology;Biological Markers;Biometry;Bronchiectasis;Calendar;Carbon Monoxide;Cause of Death;co-infection;Collaborations;COVID-19;Data;Diagnosis;Diffusion;Disabling;Disease;Disease Outcome;Disease Progression;Effectiveness of Interventions;Epidemiology;Ethanol toxicity;exercise capacity;Foundations;Future;Goals;hazardous drinking;Health;Health Personnel;Heavy Drinking;High Prevalence;HIV;HIV/AIDS;HIV/TB;Immune System Diseases;Immunologics;Immunology;improved;Infectious Agent;interest;International;Intervention;Interview;Knowledge;Link;Lung;Lung Diseases;Lung infections;lung injury;Malnutrition;Measures;men;Methods;modifiable risk;Observational Study;Outcome;Outcome Assessment;Perception;Persons;phosphatidylethanol;Physiological;Physiology;Pneumonia;Predisposition;primary outcome;Productivity;Pulmonary Function Test/Forced Expiratory Volume 1;Pulmonary function tests;Pulmonary Tuberculosis;Pulmonology;Readiness;Research;Respiratory Signs and Symptoms;Risk;Risk Factors;Role;Scanning;secondary outcome;Severity of illness;Smoking;smoking intervention;smoking prevalence;substance use;Testing;Time;timeline;Toxic effect;Translating;treatment adherence;Tuberculosis;Tuberculosis diagnosis;tuberculosis treatment;Uganda;Vital capacity;Walking;Woman;Work;X-Ray Computed Tomography

PROJECT_TITLE: The Role of Alcohol Use in Lung Disease After Treatment for Active TB Disease Among Persons Living with HIV


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: The goal of this research proposal is to use bio-orthogonal chemistry to determine protein changes in specific brain cells during normal aging and in a mouse model of Alzheimer’s disease. This research will drive our understanding of the molecular pathways perturbed by the disease that impact learning and memory, creating a new focus for therapies.

PI_NAMEs: CLINE, HOLLIS T.;MAXIMOV, ANTON ;YATES III, JOHN R (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Affect;Affinity Chromatography;Age;age related decline;Aging;aging brain;aging related;Alleles;Alzheimer's Disease;Alzheimer's disease model;American;Amino Acids;Amyloid beta-Protein Precursor;amyloid peptide;Animal Model;Architecture;Association Learning;Astrocytes;baby boomer;Biochemical;bioinformatics pipeline;Biotin;Brain;brain cell;Brain region;Cell Death;Cell Physiology;cell type;Cells;Charge;chemical genetics;Chemistry;Chronic;Complement;Cre driver;Data;deep sequencing;Defect;Detection;Development;Disease;Disease Progression;Electrophysiology (science);Enterobacteria phage P1 Cre recombinase;Epigenetic Process;Etiology;excitatory neuron;experience;extracellular;familial Alzheimer disease;frontal lobe;Genes;genetic approach;Genetic Transcription;Genomics;Glutamates;Goals;healthy aging;Hippocampus;human old age (65+);hyperphosphorylated tau;Image;Impaired cognition;Impairment;in vivo evaluation;inducible Cre;inhibitory neuron;insight;Interneurons;Knock-in;Knowledge;Label;Learning;Longitudinal Studies;Mass Spectrum Analysis;Measurement;Measures;member;Membrane;Memory;memory encoding;Memory Loss;memory retrieval;Messenger RNA;Metabolism;Methionine;Methionine-tRNA Ligase;Methods;Microglia;Molecular;Monitor;mouse model;Mouse Protein;Mus;mutant;Nature;Nerve Degeneration;Nervous System;neural;neural circuit;Neurodegenerative Disorders;Neuroglia;neuroinflammation;neuron loss;Neurons;Neurotransmitters;normal aging;novel;novel marker;optical imaging;optogenetics;Paint;Pathway interactions;Patients;Pharmaceutical Preparations;Physiological;Population;Post-Translational Protein Processing;Principal Investigator;Property;Protein Biosynthesis;protein degradation;Protein Dynamics;protein misfolding;Proteins;Proteome;proteomic signature;Proteomics;proteostasis;proteostasis loss;Recording of previous events;Research;Research Proposals;Resources;Rest;Risk Factors;Signal Transduction;Structure;Synapses;Synaptic plasticity;tau Proteins;Testing;tool;Transfer RNA;Translations;virtual

PROJECT_TITLE: Cell Specific Perturbations of the Proteome in Alzheimer's Disease


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Serious Mental Illness

PHR: PROJECT NARRATIVE Obsessive-compulsive symptoms (OCS) such as intrusive thoughts, excessive worries, and repetitive behaviors have a lifetime prevalence of 30%; onset during childhood increases risk for obsessive compulsive disorder (OCD), but can also spontaneously remit with time. To date, the neurodevelopmental trajectory of OCS remains poorly characterized. The goal of this proposal is to use computational methods to identify neural signatures that reliably represent OCS, predict longitudinal trajectories and response to first-line psychiatric treatment.

PI_NAMEs: SHI, TRACEY CHEN (contact)

PROJECT_TERMS: Adolescent;Affect;aged;Area;attenuation;base;Big Data;Brain;case control;Child;Childhood;Clinical;Clinical Data;clinical development;Clinical Skills;clinically relevant;clinically significant;cognitive development;Cognitive Therapy;Communities;Complex;computerized tools;Computing Methodologies;Data;Data Set;design;Development;Diagnosis;Diffuse;Disabling;Disease remission;Early Intervention;Exhibits;Family;follow-up;Functional Magnetic Resonance Imaging;Future;Generations;Goals;image processing;improved;Individual;Life;Machine Learning;machine learning algorithm;machine learning method;Magnetic Resonance Imaging;Major Depressive Disorder;Medical center;Mental disorders;Modality;National Institute of Mental Health;neural;neuroimaging;neuromechanism;New York;New York City;novel;Obsessive compulsive behavior;Obsessive-Compulsive Disorder;Oral;Outcome;Pattern;Physicians;predicting response;Prediction of Response to Therapy;predictive signature;Prevalence;prevent;Prevention strategy;Probability;prospective;psychiatric symptom;Psychiatric therapeutic procedure;Psychiatry;repetitive behavior;Reproducibility;Research;Research Proposals;Resources;response;Rest;Risk;Sampling;Scientist;Severities;Site;Spontaneous Remission;supervised learning;symptomatic improvement;Symptoms;Technical Expertise;Techniques;Testing;theories;Thinking;Time;Training;treatment strategy;United States;Universities;unsupervised learning;Writing;Youth

PROJECT_TITLE: Resting state connectivity signatures of obsessive compulsive symptoms


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: PROJECT NARRATIVE: The proposed research is highly relevant to public health in that survival rates for most cancer types remain stubbornly low despite advances in genomics. This work attempts to directly address this challenge by enabling both basic and translational cancer researchers worldwide to easily discover the key ‘dependencies’ of every major tumor type so that existing drugs may be rapidly repurposed or new targets can be investigated therapeutically. This effort will enable researchers in both academia and industry to advance precision medicine towards greater numbers of patients.

PI_NAMEs: MONTGOMERY, PHILIP  (contact);VAZQUEZ, FRANCISCA

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Academia;Address;Advanced Development;anti-cancer research;application programming interface;Back;base;Basic Cancer Research;Biological;Cancer cell line;cancer genomics;cancer type;cBioPortal;Cell Line;Cell model;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communication;Communities;Complement;Computational algorithm;computerized tools;CRISPR/Cas technology;Data;data access;Data Analyses;data harmonization;data portal;Data Set;Dedications;Dependence;Development;drug discovery;drug repurposing;drug sensitivity;Education and Outreach;Educational workshop;Environment;experience;experimental study;Feedback;Fostering;Friends;Funding;Funding Agency;Future;gene function;Genes;genome-wide;Genomics;Genotype;Goals;Human;Industry;Institution;interest;interoperability;Intuition;Investments;Laboratories;Laboratory Research;Learning;Maintenance;Malignant Neoplasms;Maps;member;Methods;Modeling;Molecular;Organoids;Outcome;outreach program;Pathway interactions;Patients;Pharmaceutical Preparations;Philosophy;precision medicine;precision oncology;predictive modeling;Protocols documentation;Public Health;Publications;Research;Research Personnel;Resources;RNA Interference;Scientific Inquiry;success;Survival Rate;Testing;Therapeutic;Time;tool;Training;translational cancer research;translational scientist;tumor;Variant;Visit;Visualization;Visualization software;webinar;Work

PROJECT_TITLE: Advanced development of the Cancer Dependency Map portal (DepMap.org)


NIH_SPENDING_CATS: Genetics;Human Genome;Kidney Disease;Organ Transplantation;Transplantation

PHR: Project Narrative The APOLLO (APOL1 Long-term Kidney Transplatation Outcomes) study is a prospective genetic study of kidney donor-recipient pairs involving donors of African ancestry. We propose to perform exome sequencing and genome-wide genotyping of 2,800 APOLLO donor-recipient pairs to comprehensively evaluate the role of non-APOL1 donor and recipient genetic factors in the determination of allograft outcomes.

PI_NAMEs: KIRYLUK, KRZYSZTOF  (contact)

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: Achievement;Address;Affect;African;African American;African ancestry;allograft rejection;Allografting;ancestry analysis;Ancillary Study;APOL1 gene;Case Study;Clinical;clinical care;clinical practice;cohort;Collaborations;Copy Number Polymorphism;Data;Data Set;Diagnostic;Disparity;Donor person;End stage renal failure;Enrollment;Ensure;Epidemiologic Methods;Epidemiology;exome;exome sequencing;experience;Exposure to;Failure;gene product;Generations;Genes;Genetic;Genetic Diseases;genetic profiling;genetic risk factor;Genetic study;genetic testing;Genetic Variation;Genome;genome wide association study;genome-wide;Genomics;Genotype;Graft Survival;high risk;Human Genetics;Human Genome;improved;Individual;innovation;International;Kidney;kidney allograft;Kidney Diseases;Kidney Transplantation;Knowledge;Lead;loss of function;Medicine;Methods;Minor Histocompatibility Antigens;Motivation;Nature;novel;Outcome;Outcome Study;Parents;Participant;Patients;Population;Positioning Attribute;precision medicine;prospective;Proteins;Reproducibility of Results;Research;Research Personnel;Retrospective Studies;Risk;risk variant;Role;Safety;Scanning;statistics;Testing;Time;Tissue-Specific Gene Expression;Transplantation;Untranslated RNA;Validation;Variant;Work

PROJECT_TITLE: Non-APOL1 genetic factors and kidney transplant outcomes

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Human Genome;Mental Health;Neurosciences

ORG_CITY: CHARLESTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative  Chronic stress alters reward-related behavior and this is accompanied by changes in neural circuit function, especially that involving the medial prefrontal cortex. Experiments in this proposal investigate the role of a novel long non-coding enhancer RNA in the epigenetic transcription mechanisms underlying chronic stress-related synaptic plasticity and reward-related behavior plasticity.

PI_NAMEs: TANIGUCHI, MAKOTO  (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: 3-Dimensional;Address;Behavior;behavioral plasticity;Biological Assay;Brain;chromatin immunoprecipitation;Chromatin Loop;chromosome conformation capture;Chronic;Chronic stress;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Data;Dendritic Spines;density;Dependovirus;DNA;Enhancers;Epigenetic Process;excitatory neuron;experience;experimental study;expression vector;Female;Functional disorder;Gene Expression;Gene Expression Process;Gene Expression Regulation;Gene Mutation;Genes;Genetic Transcription;Goals;hippocampal pyramidal neuron;Human Genome;Hybrids;Image;In Vitro;Individual;Induced Neurons;innovation;insight;knock-down;Knowledge;Link;male;mammalian genome;Measures;Medial;Mediating;Messenger RNA;Minor;Modeling;Molecular;Morphology;Mus;neural circuit;Neurons;neuropsychiatry;neurotransmission;novel;NPAS4 gene;Nucleus Accumbens;overexpression;patch clamp;Pathologic;Physiological;preference;Prefrontal Cortex;Proteins;Psychiatry;psychological stressor;Psychosocial Stress;psychosocial stressors;recruit;Regulation;Research;response;Rewards;RNA;rodent genome;Role;Self Administration;small hairpin RNA;social defeat;Stress;Structure;Sucrose;Synapses;Synaptic plasticity;Synaptic Transmission;transcription factor;Transcription Initiation Site;transmission process;Untranslated RNA;vector

PROJECT_TITLE: Long non-coding enhancer RNA controls stress-induced changes in reward-related behaviors

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Nutrition;Pancreatic Cancer;Rare Diseases

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: PROJECT NARRATIVE Pancreatic ductal adenocarcinoma (PDAC) is projected to be the second leading cause of cancer-related death in the United States and has been recognized as a recalcitrant cancer that requires accelerated research via the implementation of a long-term strategic plan. Glutamine is the most depleted amino acid in PDAC tumors and to bypass nutrient deficiency, the tumor cells augment their metabolism through macropinocytosis, a mechanism of fluid uptake that serves as an amino acid supply route. We have identified new regulators of macropinocytosis that represent novel drug targets for this disease and we propose to study how these enzymes function in PDAC tumor growth and therapy.

PI_NAMEs: COMMISSO, COSIMO  (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Acceleration;Actins;Amino Acids;analog;Animal Model;atypical protein kinase C;Biological Models;Bypass;cancer cell;Cancer Etiology;cancer therapy;cell growth;Cell Proliferation;Cell Survival;Cells;Cessation of life;Consumption;Cytoskeleton;Data;deprivation;Development;Disease;Ecosystem;EGFR inhibition;Enzymes;Epidermal Growth Factor Receptor;Evaluation;experimental study;Extracellular Protein;Funding;Gene Expression;Glutamine;glutamine analog;Growth;Human;In Vitro;in vivo;knock-down;Ligands;Liquid substance;Malignant Neoplasms;Metabolic;Metabolic stress;Metabolism;Microtubules;mimetics;mimicry;Modality;Molecular;neoplastic cell;new therapeutic target;Norleucine;Normal tissue morphology;novel;novel therapeutics;Nutrient;Oncogenes;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pathway interactions;Phosphorylation;Phosphotransferases;Play;Process;Production;Proliferating;Proteins;Reaction;Regulation;Research;response;Role;Route;Signal Transduction;Small Interfering RNA;Source;Specimen;Starvation;Strategic Planning;Stress;stress tolerance;Testing;tumor;tumor growth;tumor microenvironment;Tumor Suppressor Proteins;United States;uptake;Work

PROJECT_TITLE: Regulation of Nutrient Stress-Induced Macropinocytosis in Pancreatic Ductal Adenocarcinoma

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: BOZEMAN

ORG_NAME: MONTANA STATE UNIVERSITY - BOZEMAN

ORG_STATE: MT

PHR: Project Narrative According to the CDC osteoarthritis affects more than 50 million Americans. As such, this project is relevant to the NIH mission and PA-20-185, as it aims to identify metabolite predictors of osteoarthritis in both the synovial fluid and blood plasma. These studies will lay the foundation for early detection of osteoarthritis before the onset of symptoms, which will support earlier therapeutic intervention toward improved clinical care.

PI_NAMEs: JUNE, RONALD KENT (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Accounting;Affect;American;Arthralgia;articular cartilage;Biochemical Reaction;Biological Factors;Biological Markers;biological systems;Biology;biomarker development;Blood Chemical Analysis;bone;candidate identification;candidate marker;Cartilage;cell type;Cellular Stress;Chondrocytes;Chronic disability;chronic pain;Circulation;Clinical;clinical biomarkers;clinical care;Clinical Trials;Cluster Analysis;cohort;Consumption;Crime;dalton;Data;Degenerative polyarthritis;Degradation Pathway;Detection;Deterioration;Development;Diagnosis;diagnostic tool;Disease;Early Diagnosis;Early identification;Early Intervention;Evaluation;Extracellular Matrix Degradation;FDA approved;Foundations;Functional disorder;Goals;Health;Heterogeneity;Human;improved;Inflammation;Inflammatory;Inflammatory Response;Injury;innovation;insight;Joints;Knowledge;Lead;Mass Spectrum Analysis;Measures;Medical;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methods;Mission;Modeling;Molecular;novel;Osteoblasts;Outcome;Pain;Pathogenesis;Pathway interactions;Patients;Pattern;Persons;Physiology;Plasma;predictive marker;predictive modeling;Process;prospective;radiological imaging;random forest;repaired;Research;Rheumatoid Arthritis;Sampling;Scientist;Severities;small molecule;statistical learning;Statistical Models;Structure;Symptoms;Synovial Fluid;Synovial joint;Techniques;Testing;Therapeutic Intervention;Time;Tissues;tool;Training;transcriptomics;United States National Institutes of Health;Universities;Validation;Vision

PROJECT_TITLE: Metabolomic Profiling to Identify Candidate Biomarker Profiles and Molecular Endotypes for Osteoarthritis

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Health Effects of Indoor Air Pollution;Patient Safety;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE The Michigan-Ohio Occupational Research Education Program (MOORE Program) is a consortium involving the University of Michigan, University of Cincinnati, and Michigan State University that will develop and provide training and research experiences for graduate students and occupational health and safety practitioners. These activities are aimed at meeting the nation’s need for a skilled workforce that can evaluate, manage, and handle hazardous substances and protect environmental and occupational health and safety. The program will help address needs in four focus areas: exposure assessment, home health care, sustainability and OHS practices, and ergonomics and aerosol exposure, and provide on-line academic and continuing education offerings, research experiences, and dissemination.

PI_NAMEs: BATTERMAN, STUART A (contact)

PROGRAM_OFFICER_NAME: CARLIN, DANIELLE J

PROJECT_TERMS: Address;Aerosols;Affect;Area;Biological;Case Study;certificate program;Community Practice;Complement;Continuing Education;design;Development;E-learning;Education;education research;Educational Curriculum;Educational process of instructing;Effectiveness;Elements;Emerging Technologies;Engineering;Ensure;Environment;Environmental Health;Environmental Protection;environmental stressor;ergonomics;Evaluation;evidence base;Exercise;experience;Exposure to;Faculty;Foundations;Future;Goals;graduate student;Guidelines;Hazardous Substances;Hazardous Waste;Health;Health Personnel;Home Care Services;Immersion;Infrastructure;innovation;Institution;Instruction;Joints;Life Cycle Stages;Link;Lung;Measures;meetings;Michigan;Modeling;multidisciplinary;Nature;Neck;Nurses;Nurses' Aides;Occupational;Occupational Health;occupational health/safety;occupational stressor;Ohio;Online Systems;Opioid;personal protective equipment;Physiologic Monitoring;Physiological;Posture;Practice Guidelines;Practice Management;Procedures;professional atmosphere;programs;Public Health;Research;Research Personnel;Research Training;Resources;Respiration;response;Risk;rural area;safety practice;skills;student participation;Students;Superfund;symposium;Techniques;Therapeutic;Time;Trainers Training;Training;Training and Education;Universities;Upper Extremity;Work;Workplace

PROJECT_TITLE: Michigan-Ohio Occupational Research Education (MOORE) Program


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Infectious Diseases;Inflammatory Bowel Disease;Microbiome

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: Project Narrative: Alterations in intestinal microbes are critical factors contributing to many chronic inflammatory conditions such as Inflammatory Bowel Disease (IBD), celiac disease, Type 1 diabetes, and rheumatoid arthritis, which collectively affect 2.01% of the U.S. population. We have discovered a completely novel role for the protein tyrosine phosphatase non-receptor type 2 (PTPN2) gene, a candidate gene for all of these autoinflammatory conditions, in restricting expansion of an IBD-associated pathobiont, adherent-invasive E. coli (AIEC). In this proposal, we will use novel in vivo and in vitro model systems to mechanistically define the cellular and molecular mechanisms by which loss of PTPN2 activity increases host epithelial cell susceptibility to AIEC invasion, and identify if clinically approved JAK inhibitors can be repurposed to alleviate this risk event.

PI_NAMEs: MCCOLE, DECLAN  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Adherent Invasive Escherichia coli;Affect;American;Anti-Bacterial Agents;anti-microbial peptide;antimicrobial;Architecture;autoinflammatory;autoinflammatory diseases;Autophagocytosis;biological adaptation to stress;Biological Models;Candidate Disease Gene;Celiac Disease;Cell Physiology;cell type;Cells;Chronic;Clinical;cohort;Colitis;Data;Defect;Defense Mechanisms;Development;Disease;dysbiosis;endoplasmic reticulum stress;Enterocytes;Epithelial Cells;Epithelium;Escherichia coli Infections;Event;Generations;Genes;Genetic;Goals;Goblet Cells;gut microbes;gut microbiota;Homeostasis;host-microbe interactions;Human;human model;IL18 gene;Immune;in vitro Model;in vivo;Infection;Inflammatory;Inflammatory Bowel Diseases;inhibitor;Insulin-Dependent Diabetes Mellitus;Integration Host Factors;Interferons;interleukin-22;intestinal barrier;intestinal epithelium;Intestinal Mucosa;Intestines;Invaded;Knockout Mice;Large Intestine;loss of function;Microbe;microbial;microbial homeostasis;microbiome composition;Molecular;mouse model;Mucous body substance;Mus;novel;novel strategies;Outcome;Paneth Cells;pathobiont;pathogen;Patients;Penetration;Permeability;Population;Predisposition;preservation;Production;Property;Protein Tyrosine Phosphatase;Recovery;Regulation;Reporting;response;Rheumatoid Arthritis;Risk;Role;Signal Transduction;Single Nucleotide Polymorphism;single-cell RNA sequencing;Small Intestines;stem cell biomarkers;Stimulus;Testing;Variant

PROJECT_TITLE: A Novel Role for PTPN2 in Intestinal Epithelial Barrier Regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-P(03)]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: LEXINGTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Title: The University of Kentucky Racial Equity Initiative Coordinating Center (UK-REI-CC) Project Narrative: The UK-REI-CC is an innovative coordinating center model centering collectivism and emphasizing the resilience of racial and ethnic marginalized communities. The UK-REI-CC will enhance and support the NIDA REI projects by providing resources for networking and training, conducting community- engaged research, data collection and analyses, and communication and dissemination. Completing the objectives of the UK-REI-CC will result in accelerating the high impact work of the NIDA Racial Equity Initiative.

PI_NAMEs: STEVENS-WATKINS, DANELLE J (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: Acceleration;Affect;Black American;Collaborations;Color;Communication;Communities;community academic partnership;community engaged research;community engagement;Community Participation;community partners;Consultations;dashboard;Data;Data Analyses;Data Collection;diversity and inclusion;Ensure;Ethnic Origin;Event;experience;Faculty;forgetting;Goals;healing;HIV;Hospitals;implementation science;Indigenous;Indigenous American;indigenous community;Inequity;innovation;Institution;Intervention;Justice;Kentucky;learning community;Limited English Proficiency;Maps;marginalized community;Measures;meetings;member;Modeling;National Institute of Drug Abuse;Needs Assessment;novel;online resource;overdose death;people of color;Pharmacology;Pharmacotherapy;Positioning Attribute;Press Releases;Publications;Qualifying;Race;Racial Equity;Randomized, Controlled Trials;recruit;Research;Research Personnel;Research Project Grants;resilience;Resource Sharing;Resources;retention rate;rural setting;Science;Series;Site;social media;structural determinants;substance use;Substance Use Disorder;synergism;System;tailored messaging;Testing;Training;Trauma;Universities;urban setting;Voice;webinar;Work


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Serious Mental Illness;Social Determinants of Health

ORG_CITY: RONDEBOSCH

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF CAPE TOWN

PHR: PROJECT SUMMARY Antenatal maternal depression (AMD) is a global mental health problem that is experienced by children in low- and middle-income countries (LMIC) 2-3 times as frequently as in high-income countries and puts them at risk of mental health problems even after maternal depression resolves. There is evidence to suggest that atypical neurodevelopment of the amygdala, as well as its modulatory brain circuits, can be detected soon after birth in children exposed to AMD. However, there is a critical need for refined characterization of neurodevelopmental trajectories from birth to early childhood that can potentially mediate poor mental health outcomes after AMD exposure, especially in low-resource settings. Here, two early-career investigators from South Africa aim to delineate deviations in growth trajectories and functional and morphological integration across the amygdala, insular and prefrontal cortex following AMD exposure. A further key aim is to determine whether environmental adversities aggravate AMD-related neurodevelopmental deviations in a LMIC setting. We propose to include 6 longitudinal neuroimaging datasets that are actively contributing to ENIGMA-ORIGINs for a cross-national analysis of amygdala, insula, and prefrontal neurodevelopment related to AMD exposure in children 0-6 years of age. AMD exposure will be defined by clinically relevant thresholds in each sample. Standardized protocols for harmonized image processing are to be applied to T2-weighted, T1-weighted, and resting state brain scans. Non-linear longitudinal growth trajectories will be estimated for regions of interest, and their intercepts and asymptotes will be compared between AMD-exposed and unexposed children. The two groups will also be contrasted on indices of intrinsic network connectivity and coordinated structural expansion across regions. The aggregation of data across four continents will give the power necessary for analyses stratified by sex and child age, mediation analysis on child internalizing and externalizing psychopathology, and exploration of interactions between AMD and socio-economic status in linear mixed models. Finally, we will utilize a unique LMIC birth cohort with AMD assessment and repeated child brain imaging to examine prevalent environmental adversities such as food insecurity, intimate partner violence, and single/unplanned parenthood as moderators of AMD-related changes to neurodevelopment. This project will provide important insights into critical periods in neurodevelopment for early manifestations of psychopathology after exposure to AMD in the global as well as LMIC context. It will provide a first explorative answer as to whether and how socio-economic advantage can provide a protective buffer against deviations in early brain development following AMD exposure. South African research capacity will grow through mastery of advanced neuroimaging techniques that can eventually be applied to many different types of local environmental adversities and allow us to participate in ENIGMA as equitable, valuable partners. Finally, the project is designed to establish the principal investigators as the world leaders on the impact of maternal depression on early brain development in low-resource settings.

PI_NAMEs: GROENEWOLD, NYNKE  (contact);IPSER, JONATHAN CLAUDE

PROGRAM_OFFICER_NAME: KING, ERIN MICHELE

PROJECT_TERMS: 6 year old;Address;Africa;Age;Amygdaloid structure;antenatal;Anterior;Attenuated;Birth;boys;Brain;Brain imaging;Brain region;Brain scan;Buffers;career;Child;Childhood;clinically relevant;cohort;Country;critical period;Cues;Data;Data Aggregation;Data Set;Databases;design;Development;early childhood;Education;Equity;experience;Exposure to;Family;food insecurity;Functional Magnetic Resonance Imaging;Funding;girls;Goals;Growth;High Prevalence;Household;image processing;Income;indexing;infancy;Infant;insight;Insula of Reil;Intercept;interest;International;Intervention;intimate partner violence;life span;Link;low and middle-income countries;Low income;low socioeconomic status;maternal depression;Mediating;Mediation;Mediator;Mental disorders;Mental Health;Modeling;Morphology;National Institute of Mental Health;neural correlate;neurodevelopment;neuroimaging;Nonlinear Dynamics;novel;novel strategies;Outcome;Prefrontal Cortex;Principal Investigator;Protocols documentation;Psychopathology;Regulation;Research;Research Personnel;Resource-limited setting;Rest;Risk;Risk Marker;Sampling;sex;Socioeconomic Status;socioeconomics;South Africa;South African;Standardization;Symptoms;Techniques;Testing;United States National Institutes of Health;Work

PROJECT_TITLE: Early brain development in children born to depressed mothers in high and low income settings


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision

ORG_CITY: PORTLAND

ORG_DEPT: PHYSIOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative The goal of this project is to develop our mechanistic understanding of the structure and function of the lens alpha-crystallins, and the aggregation pathways associated with age-related cataract formation. We are applying technologies in single particle CryoEM to illuminate these mechanisms with atomistic-levels of detail. These studies will provide critical knowledge required for the development of rational drug-design strategies, targeted at controlling cataracts and a range of other crystallin-opathies.

PI_NAMEs: REICHOW, STEPHEN LOEN (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TITLE: Structure, function and aggregation of lens α-crystallins by CryoEM

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-A(02)M]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Infectious Diseases;Machine Learning and Artificial Intelligence

ORG_CITY: CHICAGO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: The bacterial pathogen Pseudomonas aeruginosa causes frequent and difficult to treat infections. Strains of P. aeruginosa differ markedly in the severity of disease that they cause. We propose to use a comparative genomic approach to understand the bases for these differences.

PI_NAMEs: HAUSER, ALAN R (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Alleles;Animal Model;Area;Bacteremia;Bacteria;base;Biological Assay;Candidate Disease Gene;Cell Culture Techniques;Characteristics;Clinical;clinical predictive model;cohort;Collection;comparative genomics;Complement;Death Rate;Disease;Elements;Etiology;Foundations;Future;gene product;Generations;Genes;genetic approach;Genome;Genomic approach;Genomics;Growth;Hospitalization;Human;human old age (65+);Infection;insertion/deletion mutation;insight;Intensive Care Units;Lethal Dose 50;machine learning model;machine learning prediction;Mediating;Modeling;Monitor;mortality;Moths;mouse model;Multi-site clinical study;multidrug-resistant Pseudomonas aeruginosa;Mus;next generation sequencing;Nosocomial Infections;novel;novel therapeutics;Outcome;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathway interactions;Patients;Performance;Pilot Projects;Play;Population Analysis;predict clinical outcome;predictive modeling;Prevalence;prognostic;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;public health priorities;Reporting;resistant strain;Risk;Role;Sepsis;sequencing platform;Severity of illness;Single Nucleotide Polymorphism;Source;Testing;Therapeutic Agents;Therapeutic Intervention;Virulence;Virulence Factors;virulence gene;Waxes

PROJECT_TITLE: Population Analysis of Pseudomonas aeruginosa Virulence

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: PROJECT NARRATIVE Racial and ethnic minority adolescents in low-resource communities (i.e., high-risk) have the highest intake of added sugar (AS) and are disproportionately at-risk for diet-related chronic disease in adulthood, highlighting that AS is a critically important and potentially impactful target for intervention efforts. This study aims to provide an in-depth understanding of the key drivers of AS intake in high-risk adolescents using ecological momentary assessment, develop a contextually tailored, technology-enriched intervention to reduce AS intake, and assess outcomes using a novel objective biomarker of AS intake. This study will leverage state-of-the-art methodologies to provide high-quality evidence on AS intake in high-risk adolescents and has the potential to reduce diet-related chronic risk during the transition to adulthood.

PI_NAMEs: TRIPICCHIO, GINA L. (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: 16 year old;abdominal fat;acceptability and feasibility;Address;Adolescent;Adult;age group;American Heart Association;Automobile Driving;Award;Behavior;Behavior assessment;behavior change;Behavior Therapy;Behavioral trial;Biological Markers;Blood specimen;Calories;cardiometabolism;cardiovascular risk factor;career development;Child;Childhood;Chronic;Chronic Disease;Communities;comparison group;Complement;Complex;Consumption;Cues;design;Development;Development Plans;Diet;dietary;Dietary Assessment;Dietary intake;Dietary Intervention;digital intervention;Dimensions;disorder risk;Disparity;Doctor of Philosophy;Eating Behavior;Ecological momentary assessment;Education;Environment;ethnic minority;experience;Goals;Hair;Health;health disparity;Healthy Eating;High Prevalence;high risk;high risk population;high-risk adolescents;Home environment;Hunger;improved;indexing;innovation;Intake;Intervention;Investigation;K-Series Research Career Programs;Life Cycle Stages;live text;Low income;Measures;Mentors;Mentorship;Methodology;Methods;minority children;Nature;novel;nutrition;Nutritional;Nutritional Study;Obesity;obesity risk;Outcome;Outcome Assessment;Parents;Participant;Patient Self-Report;Pattern;peer influence;Phase;Philadelphia;pilot test;Population;Population Heterogeneity;primary outcome;programs;Public Health;racial minority;Randomized;Randomized, Controlled Trials;Recommendation;Reducing diet;Reporting;Research;Resource-limited setting;Resources;Risk;Sampling;Satiation;Schools;secondary outcome;Source;stable isotope;Statistical Models;statistics;Strategic Planning;sugar;sweetened beverage;Technology;Testing;Text Messaging;Time;Training;transition to adulthood;Unhealthy Diet;United States National Institutes of Health;Universities;vulnerable adolescent;Work;Youth

PROJECT_TITLE: Targeting added sugar to improve dietary intake in high-risk adolescents

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]