NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE In Lewy body dementia (LBD) and Alzheimer’s disease (AD) models, Hsp70, which assists in protein folding, can correct pathology caused by -synuclein, tau and Abeta proteins. While the mechanism of Hsp70 protection is unknown, our data suggest a very non-standard and specific mode of action, which we seek to determine in atomic detail and verify both in LBD cell models and in AD (tau and Abeta) biochemical assays. If verified, this mechanistic understanding will provide a specific pathway to exploit for treatment of LBD and AD.

PI_NAMEs: AGARD, DAVID A.;MCCONLOGUE, LISA C (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: abeta oligomer;Affect;alpha synuclein;Alzheimer's Disease;Alzheimer's disease model;Amyloid beta-Protein;Animal Disease Models;Animal Model;Binding;Binding Sites;Biochemical;Biological Assay;Biological Process;Cell model;Cell Physiology;Cells;Client;Clinical;cost;Cryoelectron Microscopy;Cytosol;Data;Dementia;Deposition;Development;Disease;Disease Progression;Ensure;Equilibrium;Future;Gene Mutation;Impairment;In Vitro;in vivo;Lewy Bodies;Lewy Body Dementia;Lipid Binding;Lipids;Maps;Mediating;Membrane;Microscopic;Molecular;Molecular Chaperones;Molecular Structure;monomer;mutant;Mutate;Mutation;Mutation Analysis;Nerve Degeneration;Neurodegenerative Disorders;Neurologic;Neurons;neurotoxic;neurotoxicity;novel;novel therapeutic intervention;Pathogenicity;Pathologic;Pathology;Pathway interactions;Persons;Play;prion-like;protective pathway;protein folding;Proteins;Publishing;Resolution;Role;side effect;Site;Societies;Stress;synuclein;targeted treatment;tau aggregation;tau mutation;tau Proteins;Testing;Therapeutic;therapeutic target;tool;Toxic effect;Translational Research;Validation;Vesicle;Visualization

PROJECT_TITLE: Chaperone protection in Lewy body and Alzheimer’s dementias: determining the structural, molecular and cellular mechanisms of a novel, non-canonical Hsp70 action blocking a-synuclein oligomerization

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Digestive Diseases;Liver Disease;Organ Transplantation;Transplantation

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Organ transplantation is a proven intervention for end-stage organ failure; however, transplants are only currently meeting ~10% of the global demand. Yet, there are untapped resources of potentially transplantable organs that could be used to save these lives. This project aims to develop a quantitative, objective metric to definitively ascertain liver viability that will enable advances in experimental and clinical transplantation aimed at increasing the availability of organs for transplant.

PI_NAMEs: TESSIER, SHANNON NOELLA (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Acute;Allografting;Animals;arm;attributable mortality;Biopsy;Body System;Cardiac Death;Cells;Cessation of life;Chronic;Clinical;Compensation;conditioning;cost;Data;Devices;Disease;end-stage organ failure;Exposure to;Family suidae;flexibility;Functional disorder;Goals;Heart;Human;imaging platform;Improve Access;indexing;Industry Collaboration;injured;Injury;innovation;Intervention;Life;Liver;liver biopsy;liver injury;liver transplantation;Logistic Regressions;Mammals;Measurement;Measures;meetings;Methodology;Methods;Mitochondria;Modeling;novel;Operative Surgical Procedures;Organ;organ allocation;Organ Donations;Organ Donor;Organ failure;organ injury;Organ Transplantation;Organ Viability;Outcome;Oxidation-Reduction;Patients;Perfusion;Play;post-transplant;preclinical study;Raman Spectrum Analysis;Rattus;Recovery;Reperfusion Injury;Research;Research Personnel;Resources;response;Risk;Rodent;Rodent Model;Role;Sampling;Scientist;success;Surface;Surgeon;Survival Rate;Technology;Time;tissue injury;Tissues;Translating;Transplantation;Validation;Waiting Lists;Warm Ischemia;Work

PROJECT_TITLE: A quantitative viability metric for liver transplantation using Resonance Raman Spectroscopy

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: NS

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: The proposed research is relevant to public health because it seeks to understand how macrophages modulate tumor cell resistance to radiotherapy and uses that knowledge to develop improved radiotherapeutic strategies for brain cancer. Once such strategies have been developed, there is the potential for significant advances in treatment for patients with brain cancer. Thus, the proposed research is relevant to the National Institute of Neurological Disorders and Stroke’s mission of seeking fundamental knowledge about neurological disorders and using that knowledge to reduce disease burden in patients.

PI_NAMEs: SCARPELLI, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: anti-tumor immune response;Brain Neoplasms;burden of illness;Canis familiaris;Caring;Cells;Clinical;clinical translation;clinically relevant;Coculture Techniques;Comb animal structure;Companions;cytotoxic;design;Development;Effectiveness;Ensure;FDA approved;ferumoxytol;Fractionated radiotherapy;Glioblastoma;Glioma;Goals;Human;imaging agent;Immunologic Stimulation;immunosuppressive macrophages;improved;improved outcome;In Vitro;in vivo;innovation;insight;iron deficiency;iron oxide nanoparticle;Knowledge;Macrophage;Magnetic Resonance Imaging;Malignant neoplasm of brain;Malignant Neoplasms;Microglia;Mission;Modeling;Mus;National Institute of Neurological Disorders and Stroke;neoplastic cell;Nervous System Disorder;Newly Diagnosed;Outcome;Patients;Predisposition;Prevalence;Progression-Free Survivals;Public Health;Radiation;Radiation therapy;Recurrence;Regimen;Research;Research Personnel;Resistance;response;Rodent;Rodent Model;Role;Safety;Signal Transduction;standard care;Supporting Cell;targeted agent;targeted treatment;Testing;Therapeutic;Therapeutic Agents;therapeutic development;therapeutic target;therapy resistant;Tissues;tool;Treatment Efficacy;tumor;tumor microenvironment;Tumor Promotion;Tumor-associated macrophages

PROJECT_TITLE: Improving glioma radiotherapy by theragnostic targeting of tumor-supporting macrophages

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Machine Learning and Artificial Intelligence;Radiation Oncology;Women's Health Research

ORG_CITY: LEXINGTON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE The goal of this program is to develop a high-throughput optical assay that enables non-destructive metabolic characterization of in vitro cell models and organoids for biomedical applications. We will demonstrate our assay for early prediction of breast cancer radiation sensitivity within the decision-making window via longitudinal metabolic characterization of patient-derived organoids under radiation stresses. The proposed work will impact the biomedical research by providing a novel tool for non-destructive metabolic measurement of cell and organoid models, and a novel paradigm for cancer patient’s radiotherapy sensitivity prediction.

PI_NAMEs: ZHU, CAIGANG  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: 4T1;Algorithms;anti-cancer research;Biological Assay;Biological Markers;Biomedical Research;Breast Cancer Model;Breast Cancer Patient;cancer cell;Cancer Model;Cancer Patient;cancer radiation therapy;cancer therapy;Cell Line;Cell model;Cells;Clinic;Clinical;Control Groups;Convulsions;Decision Making;Evaluation;experience;experimental group;Fatty Acids;Fiber;Fluorescence;fluorophore;Future;Genus Hippocampus;glucose uptake;Goals;high throughput screening;improved;In Vitro;in vivo;Incubated;indexing;innovation;Light;Machine Learning;machine learning algorithm;Malignant Breast Neoplasm;Matrix Metalloproteinases;Measurement;Measures;Membrane Potentials;Metabolic;Metabolism;metabolomics;mitochondrial membrane;Modeling;Nature;new technology;novel;novel strategies;Optics;Organoids;Outcome;Patients;Performance;pilot test;pre-clinical;preclinical study;predictive modeling;Preparation;programs;Radiation;radiation response;Radiation therapy;Radiation Tolerance;radioresistant;Reader;Regimen;Role;Sampling;Siblings;Source;Specimen;Spectrum Analysis;Standardization;Stress;Survival Rate;System;Techniques;Technology;Testing;Therapeutic;Therapeutic Studies;Time;Tissues;tool;tumor;tumor growth;tumor metabolism;Update;uptake;Work

PROJECT_TITLE: Non-destructive optical spectroscopic assay for high-throughput metabolic characterization of in vitro cell models  and patient-derived organoids


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Depression;Disability Research;Headaches;Mental Health;Mental Illness;Migraine;Neurosciences;Pain Research;Pediatric;Rehabilitation;Sleep Research

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE Insomnia is common and highly comorbid among adolescents with migraine, impacting 65-71% of youth. The proposed project will determine efficacy of cognitive-behavioral therapy (CBT) for insomnia, as well as the combined effect of CBT insomnia and pain interventions, on reducing insomnia symptoms and headache-related disability in adolescents with migraine. Our long-term goal is to offer effective, tailored self-management interventions that can address migraine and co-morbid sleep problems in adolescence and disrupt a cycle of persistent, disabling migraine from continuing into adulthood.

PI_NAMEs: LAW, EMILY F;PALERMO, TONYA M (contact)

PROGRAM_OFFICER_NAME: KING, TRACY

PROJECT_TERMS: actigraphy;Address;Adolescence;Adolescent;Adult;Aftercare;Age;Anxiety;anxiety symptoms;Arousal;Arthritis;Auras;barrier to care;Beds;Behavioral;Caffeine;Child;Childhood;Chronic;chronic pain;clinical practice;Cognitive;Cognitive Therapy;cohort;Comorbid Insomnia;comorbidity;coping;cost;Data;depressive symptoms;diaries;digital health;Dimensions;disability;Disabling;Education;efficacy evaluation;efficacy testing;Emotional;experience;follow-up;Frequencies;Future;Goals;Headache;Headache disability;Health;Health Care Costs;health related quality of life;health service use;Healthcare;High Prevalence;Hygiene;improved;Individual;innovation;Internet;internet delivery;Intervention;Knowledge;Maintenance;Malignant Neoplasms;Mediating;Mediator;Mental Depression;Methods;Migraine;Monitor;Napping;novel;Online Systems;Outcome;Pain;Pain intensity;Pain management;pain outcome;Pain Research;Parents;Patient Self-Report;Pattern;Persons;Phase;phase II trial;poor sleep;Population;post intervention;primary outcome;programs;psychologic;Quality of life;Questionnaires;Randomized;Randomized, Controlled Trials;Recording of previous events;Reporting;Research;response;Risk;Risk Factors;secondary outcome;Self Management;Severities;Sleep;sleep behavior;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep health;sleep pattern;sleep physiology;sleep quality;Sleeplessness;Symptoms;Testing;Time;treatment comparison;trial comparing;trial design;Visit;Youth

PROJECT_TITLE: Enhancing Efficacy of Migraine Self-Management in Children with Comorbid Insomnia

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Pancreatic cancer is an almost uniformly lethal disease and is characterized by an intense fibroinflammatory stromal reaction and a hypoxic microenvironment. Tumor-stroma crosstalk substantially contributes to disease progression and therapeutic resistance, and the goal of this proposal is to elucidate the mechanisms by which hypoxia regulates localization and function of fibroblasts and immune cells in pancreatic cancer by modulating the tumor-stroma crosstalk. Our studies will provide new insights into the role of hypoxia in shaping the tumor stroma in pancreatic cancer, which can be exploited to develop effective stroma-targeting strategies against pancreatic cancer.

PI_NAMEs: LEE, KYOUNG EUN  (contact)

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: 3-Dimensional;Area;Blood Vessels;cancer cell;cancer type;CCL2 gene;CD8-Positive T-Lymphocytes;Cells;Clinical;Coculture Techniques;coping;cytokine;Data;density;design;Disease;Disease Progression;Exclusion;experience;Extracellular Matrix;Fibroblasts;Goals;Human;Hypoxia;Hypoxia Inducible Factor;Immune;In Vitro;Infiltration;Inflammatory;insight;Knowledge;LIF gene;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;mouse model;Mus;Myelogenous;Neoplasm Transplantation;neoplastic cell;normoxia;novel therapeutic intervention;Outcome;Oxygen;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;Phenotype;rapid growth;Reaction;recruit;Regulation;response;Role;Shapes;Stress;Stromal Cells;Survival Rate;System;T cell infiltration;T-Lymphocyte;targeted treatment;Tars;Testing;therapy resistant;tumor;tumor growth;tumor hypoxia;tumor progression;tumor-immune system interactions

PROJECT_TITLE: Role of Hypoxia in Shaping the Tumor Stroma in Pancreatic Cancer

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Microbiome;Nanotechnology;Rare Diseases;Tuberculosis

ORG_CITY: Chapel Hill

ORG_NAME: TRIANGLE BIOTECHNOLOGY, INC.

ORG_STATE: NC

PHR: Narrative There is a growing need to improve next-generation sequencing (NGS) techniques for applications such as pathogen detection, strain identification, and drug susceptibility testing. Triangle Biotechnology is developing a novel lysis technology that drastically improves DNA extraction from lysis-resistant infectious pathogens, a current bottleneck in NGS workflows. The integration of this technology with in-vitro diagnostic platforms will assist in alleviating the public health burden of infectious diseases.

PI_NAMEs: KASOJI, SANDEEP  (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Accounting;Acinetobacter baumannii;Acoustics;Antibodies;Bacteria;Binding;Biological;Biological Assay;Biotechnology;Blood;California;Candida albicans;Cell Nucleus;Cell surface;Cell Wall;Cells;cellular resilience;Cessation of life;Chemicals;Clinical;clinical diagnostics;clinically relevant;Communicable Diseases;Communities;cost;Cytolysis;design;Detection;Development;Devices;Diagnosis;Diagnostic;diagnostic platform;Diagnostic Sensitivity;direct application;DNA;Drug resistance;Drug resistant Mycobacteria Tuberculosis;drug testing;Enterococcus faecalis;Fluorometry;Food Safety;Formulation;Foundations;Genes;Genus Mycobacterium;Gram-Positive Bacteria;Health;Human;improved;in-vitro diagnostics;innovation;Lead;Lectin;Ligand Binding;Ligands;Measures;mechanical force;Mechanics;Metagenomics;Methodology;Methods;Microbe;microbial;microbiome;microbiome research;microorganism;Modeling;Molecular Analysis;Molecular Diagnosis;Morbidity - disease rate;mortality;Mycobacterium smegmatis;Mycobacterium tuberculosis;nanoDroplet;next generation sequencing;novel;novel diagnostics;Nucleic Acid Amplification Tests;Nucleic Acids;pathogen;Pathogen detection;pathogen genomics;Patients;Peptides;Performance;Pharmaceutical Preparations;Phase;Polymerase Chain Reaction;Population;Predisposition;preservation;Protocols documentation;Public Health;Reagent;Reproducibility;Research;resilience;Resistance;safety testing;Sampling;screening;Shock;Sonication;Sputum;statistics;Techniques;Technology;technology validation;Testing;Thick;tool;Tuberculosis diagnosis;Universities;Urine

PROJECT_TITLE: Improving diagnostic sensitivity for difficult-to-lyse microbial samples with nanodroplet technology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-V(13)]


ORG_CITY: Aurora

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative In this proposal we aim to continue to understand the mechanisms involved in antigen archiving that lead to protective immune responses. These studies will provide a more in depth understanding of the cellular processes and communication necessary for the handling of antigens over time in order to benefit protective immunity.

PI_NAMEs: TAMBURINI, BETH ANN (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: adaptive immune response;Address;Affect;antigen detection;Antigen Presentation;Antigens;Archives;Attenuated Vaccines;Award;Bar Codes;Caveolins;CD8-Positive T-Lymphocytes;Cell Communication;Cell Physiology;Cell Shape;cell type;Cells;Cellular Immunity;Communication;Conjugate Vaccines;Data;Dendritic Cells;design;Development;DNA;emerging pathogen;Event;Exocytosis;Flow Cytometry;Funding;Future;Gene Expression Profile;Genes;Genetic Transcription;genomic platform;grasp;Hand;Hematopoietic;ICAM1 gene;Immune response;Immunity;Immunologic Memory;improved;Infection;Inflammation;Inflammatory;Lead;Learning;lymph nodes;Lymphatic;Lymphatic Endothelial Cells;Measures;Memory;Messenger RNA;Methodology;Methods;Molecular;novel;prevent;Process;programs;Proliferating;protein degradation;Proteins;Publishing;secondary infection;Secondary to;Signal Transduction;single cell mRNA sequencing;Source;subcutaneous;Surface;T cell response;T memory cell;Techniques;Technology;Time;Tissues;trafficking;transcriptome;Vaccination;vaccination strategy;Vaccine Design;vaccine strategy;Vaccines;Viral;Viral Antigens;Virus;Virus Diseases

PROJECT_TITLE: Cooperation between lymphatic stroma and hematopoietic cells shapes protective immunity

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Estrogen;Neurosciences;Sleep Research;Women's Health Research

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Women are more susceptible to performance impairment in response to acute sleep loss during the follicular phase of the menstrual cycle. This menstrual-phase-dependent susceptibility may be indirectly mediated by progesterone and estradiol via their effect on core body temperature, but it is unknown whether these effects persist under more realistic patterns of chronic sleep loss. This work will fill this important gap in knowledge and inform future interventions to mitigate the impact of sleep loss in women.

PI_NAMEs: RAHMAN, SHADAB A (contact);ST HILAIRE, MELISSA APRIL

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: Acceleration;Acute;Address;Admission activity;Adolescence;alertness;Attention;Awareness;Beds;Body Temperature;Chronic;cognitive performance;Contraceptive methods;design;Deterioration;Drowsiness;Endocrine;Estradiol;Exhibits;Exposure to;Failure;Female;female sex hormone;Future;Goals;Gonadal Steroid Hormones;Health;Hormonal;Hormone replacement therapy;Hour;Impairment;improved;Individual;infertility treatment;Inpatients;Intervention;Knowledge;life span;Luteal Phase;male;Measures;Mediating;men;Menopause;Menstrual cycle;neurobehavioral;novel therapeutics;Outcome;Participant;Pattern;Performance;performance tests;Phase;Predisposition;Pregnancy;Premenopause;Progesterone;proliferative phase Menstrual cycle;Protocols documentation;Randomized;Reaction Time;Recommendation;Recovery;Reporting;response;Role;Satiation;Schedule;Scheme;Severities;Sex Differences;Sleep;Sleep Deprivation;sleep pattern;sleep regulation;Testing;Time;Variant;vigilance;Woman;Women's study;Work

PROJECT_TITLE: Menstrual-phase-dependent differences in response to chronic variable sleep loss

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention

ORG_NAME: TSRL, INC.

PHR: Project Narrative TSRL is developing a novel transdermal delivery product of zanamivir for the treatment and prevention of the flu. The proposed research will establish the proof-of-concept that effective treatment of the flu can be achieved with a patch.

PI_NAMEs: LIPKA, ELKE  (contact)

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: absorption;Acute;Adamantane;Address;Agreement;Cessation of life;Characteristics;Circulation;Clinical;clinical development;Communities;COVID-19 pandemic;Data;Development;Development Plans;Devices;Disease;Dose;Drug Kinetics;Dryness;economic impact;effective therapy;Effectiveness;Elderly;endonuclease;Engineering;Ensure;Epidemic;Epithelium;Family suidae;flu;Formulation;Future;Human;Hydrogels;improved;Influenza;influenza epidemic;influenza infection;influenza outbreak;Influenza prevention;influenza virus strain;influenzavirus;Inhalation;Inhalation Drug Administration;inhibitor;Kinetics;Light;Liquid substance;Literature;Lung;manufacturability;manufacture;Marketing;Medical;Methods;Miniature Swine;Modeling;mortality;Needles;Neuraminidase inhibitor;novel;novel therapeutics;Oral;Oseltamivir;Pain;Painless;pandemic disease;Pathogenicity;patient population;Patients;Persons;Pharmaceutical Preparations;Pharmaceutical Services;pharmacokinetics and pharmacodynamics;Pharmacotherapy;Phase;Population;Powder dose form;pre-Investigational New Drug meeting;preclinical study;prevent;product development;programs;Property;prototype;Publishing;Puncture procedure;Rattus;Recommendation;Research;Resistance;resistant strain;respiratory;Respiratory System;Risk;Route;Safety;scale up;seasonal influenza;Seasons;Site;Skin;skin barrier;Small Business Innovation Research Grant;Specific qualifier value;Syringes;System;Therapeutic;Toxicology;Transdermal substance administration;transmission process;Vaccination;vaccine effectiveness;Vaccines;Visit;Work;zanamivir

PROJECT_TITLE: Microneedle Delivery of Zanamivir for the Treatment of Influenza Infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-C(12)]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

ORG_CITY: ROCHESTER

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE – OVERALL COMPONENT The mechanisms and the biomarkers of developing food allergy are poorly understood, but it is known that traditional, agrarian lifestyle provides protection against atopic diseases starting in early life. In this proposal utilizing samples and clinical data from a longitudinal birth cohort study, we will evaluate the development of the microbiome, skin barrier function and skin and systemic immune system in urban infants at high risk for atopic diseases and in farming lifestyle infants. These studies will provide critical new knowledge about the biomarkers and mechanisms of early development of and protection against atopic diseases, and lay the groundwork for future studies of prevention of allergic diseases in childhood.

PI_NAMEs: JARVINEN-SEPPO, KIRSI  (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: 5 year old;adaptive immunity;Allergens;Allergic;Allergic Disease;Asthma;Atopic Dermatitis;atopy;Bathing;biobank;Bioinformatics;Biological Markers;biomarker identification;Birth;Blood;Cells;Child;Childhood;Clinical Data;clinical development;Cluster Analysis;cohort;Cohort Studies;comparison group;Consumption;cytokine;Data;data management;Development;Diet;Disease;early childhood;early onset;Eating;Epithelial Cells;Europe;Exposure to;Extrinsic asthma;Family;Farm;Feces;food allergen;Food Hypersensitivity;Foundations;Funding;Future;Generations;Grant;gut microbiome;high risk;high risk infant;Home;Homing;House Dust;Human;Hypersensitivity;Immune;Immune response;Immune system;Immunologic Markers;Impairment;Incidence;Individual;individualized prevention;infancy;Infant;infant gut microbiome;Inflammation;Inflammatory;Infrastructure;Innate Immune System;Knowledge;Lead;Life;Life Style;Livestock;Memory;Mennonite;metabolome;metagenomic sequencing;microbial;microbiome;microbiome composition;Milk;monocyte;Natural Immunity;North America;organizational structure;Permeability;Population;preservation;Prevention;Production;programs;recruit;Regulatory T-Lymphocyte;respiratory;Risk;sample collection;Sampling;Skin;skin barrier;skin microbiome;Swab;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Training;transcriptome;transcriptomics;Tryptophan;TSLP gene;unpasteurized;urban children;Volatile Fatty Acids

PROJECT_TITLE: Biomarkers of Atopy Beginning Early (BABE)


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Eczema / Atopic Dermatitis;Food Allergies;Nutrition;Pediatric;Prevention

PROJECT_TERMS: Accidents;Adherence;Allergens;Allergic;Allergy to peanuts;Anaphylaxis;Antigens;Atopic Dermatitis;atopy;biobank;Bioinformatics;Biological Markers;cohort;Collaborations;Communication;conflict resolution;cost;Data;data management;data sharing;Development;Disease;Ensure;Farm;Feedback;Food;Food Hypersensitivity;Gastrointestinal tract structure;Goals;Immune response;Immunosuppression;improved;Individual;infancy;Infant;Internet;Intervention;Leadership;Life;Life Style;Mediating;meetings;Mennonite;Modeling;Monitor;National Institute of Allergy and Infectious Disease;oral tolerance;organizational structure;Play;Population;prevent;Prevention;programs;Progress Reports;Publications;Quality of life;Reaction;Regulatory T-Lymphocyte;Research;Research Personnel;Resource Sharing;Resources;respiratory;Risk;Risk Factors;Role;Science;Severities;Skin;Solid;standard of care;success;Supervision;symposium;Time;timeline;Urticaria;Vertebral column

PROJECT_TITLE: Administration Core


ADMINISTERING_IC: GM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative  Postoperative acute kidney injury (AKI) occurs in 20% of patients following cardiac and vascular surgery and increases the risk of developing chronic kidney disease and death. We have demonstrated that a higher preoperative high-density lipoprotein (HDL) cholesterol concentration is associated with a reduced risk of AKI after cardiac surgery, and now proposed studies to test the hypothesis that apolipoprotein A-I and specific miRNAs on HDL suppress endothelial intercellular adhesion molecule 1, renal tubule toll-like receptor (TLR) 2 and TLR4 expression, and reduce AKI. These studies will provide the candidate with experience in prospective clinical research, miRNA sequencing, and preclinical murine models of AKI, preparing her to establish an independent translational research career focused on developing novel methods of reducing postoperative AKI.

PI_NAMEs: SMITH, LOREN ELISA (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA ALISE

PROJECT_TERMS: Academic Medical Centers;Activities of Daily Living;Acute Renal Failure with Renal Papillary Necrosis;Affect;Anesthesiology;Apolipoprotein A-I;Apolipoproteins;atorvastatin;Award;Bioinformatics;Blood;Blood Vessels;Cardiac;Cardiac Surgery procedures;career;career development;Cells;Cessation of life;Characteristics;Chronic Kidney Failure;Clinical Data;Clinical Research;Core Facility;Creatinine;Data;Doctor of Philosophy;Dose;Endothelial Cells;Endothelium;Environment;Enzyme-Linked Immunosorbent Assay;experience;Experimental Designs;experimental study;F2-Isoprostanes;Faculty;Fellowship;Free Radicals;Goals;High Density Lipoprotein Cholesterol;high density lipoprotein-1;High Density Lipoproteins;Hospitals;Hour;Human;Hypoxia;IGFBP2 gene;In Vitro;in vivo;Incubated;injury prevention;Injury to Kidney;Institution;insulin-like growth factor binding protein-related protein 1;Intercellular adhesion molecule 1;Ischemia;ischemic injury;K-Series Research Career Programs;Kidney;Lecithin;Lipid Peroxidation;Lipoproteins;Measurement;Measures;Mediating;Mentors;Mentorship;Methods;MicroRNAs;miRNA expression profiling;Modeling;Molecular Biology;mouse model;Mus;Neutrophil Infiltration;novel;Operative Surgical Procedures;Outcome;Oxidative Stress;particle;Patients;Perioperative;pharmacologic;Phenotype;Plasma;Postoperative Period;pre-clinical;prevent;Program Development;prospective;Prospective Studies;Proteins;Proximal Kidney Tubules;rat KIM-1 protein;Rattus;recruit;renal damage;renal ischemia;Renal tubule structure;Reperfusion Injury;Reperfusion Therapy;Research;Residencies;Reverse Transcriptase Polymerase Chain Reaction;Risk;Serum;Severities;sham surgery;skills;Stress;Study Subject;Testing;Therapeutic;Time;Tissue Inhibitor of Metalloproteinases;TLR2 gene;TLR4 gene;TNF gene;Training;Translational Research;translational research program;Tubular formation;Universities;urinary;Urine;Vesicle;Western Blotting

PROJECT_TITLE: Perioperative high-density lipoproteins and postoperative AKI

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Asthma;Clinical Research;Digestive Diseases;Eczema / Atopic Dermatitis;Food Allergies;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Microbiome;Nutrition;Pediatric;Prevention

PI_NAMEs: SEPPO, ANTTI  (contact)

PROJECT_TERMS: 6 year old;Age;Allergens;Allergic;Allergic Disease;Asthma;Atopic Dermatitis;atopy;biobank;Biological Markers;biomarker identification;Birth;Child;Childhood;Clinic;Clinical;clinical development;cohort;Cohort Studies;Communities;comparison group;computerized data processing;Consumption;County;cytokine;Data;data infrastructure;Development;Diagnosis;Disease;early childhood;early onset;Epigenetic Process;Epithelial Cells;Equipment and supply inventories;Europe;Exposure to;Family;Farm;Feces;Fingers;First Degree Relative;follow-up;food allergen;Food Hypersensitivity;German population;gut microbiome;Hay fever;high risk;Home;House Dust;Hypersensitivity;Immune;Immunologic Markers;Immunology;Impairment;Incidence;Individual;Infant;Infant Development;infant gut microbiome;Inflammatory;Innate Immune System;Insurance;Life;Life Style;Livestock;Measures;Medical;Mennonite;Metabolic Pathway;metabolome;Metadata;microbial;microbiome composition;Milk;neonate;North America;novel strategies;Outcome;Patient Self-Report;peripheral blood;Permeability;Physicians;Population;Pregnant Women;prenatal;Prevention strategy;Primary Prevention;Process;Production;programs;recruit;Regulatory T-Lymphocyte;research clinical testing;Research Personnel;respiratory;Risk;sample collection;Sampling;School-Age Population;Secondary Prevention;shared database;Siblings;Signs and Symptoms;Skin;skin barrier;Surveys;Swab;symposium;Testing;TSLP gene;unpasteurized;urban children;Visit;Woman

PROJECT_TITLE: Cohort Administration and Biorepository Core


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Type 1 diabetes is a disorder that results from dysfunction and death of islet β cells. The identification and characterization of new pathways promoting stress in β cells would allow for the institution of defined therapies that protect β cells and their function. This application proposes to study the pathways that activate the integrated stress response in β cells and how this response leads to promotes the dialog with immune cells to propagate autoimmunity in type 1 diabetes.

PI_NAMEs: MIRMIRA, RAGHAVENDRA G (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: 12-HETE;adaptive immunity;Adoptive Transfer;Arachidonate 12-Lipoxygenase;Autoimmune Diseases;Autoimmunity;Award;B-Lymphocytes;Beta Cell;Biological;biological adaptation to stress;Biological Models;Cell Communication;cell killing;Cell Physiology;Cells;Cessation of life;Clinical;Coculture Techniques;Communication;cytokine;Cytoprotection;cytotoxic;Data;Dependence;Development;diabetes pathogenesis;Diabetes prevention;Disease;Disease remission;Drug usage;Eicosanoids;EIF-2alpha;Emergency Situation;Energy Metabolism;Event;experimental study;Functional disorder;Funding;Gene Silencing;Genetic;Genetic Transcription;Human;Immune;Immune response;Immune system;Immune Targeting;Immunologist;Immunophenotyping;In Vitro;in vivo;Inbred NOD Mice;Inflammation;Inflammatory;Institution;Insulin-Dependent Diabetes Mellitus;insulitis;intercellular communication;islet;Knockout Mice;Lead;Link;Lower Organism;Mediating;Messenger RNA;Modeling;Modification;Molecular;mouse model;mRNA Translation;Mus;Myelogenous;Natural Immunity;novel;nutrient deprivation;Outcome;Pathogenesis;Pathway interactions;pharmacologic;Phosphorylation;Phosphotransferases;Positioning Attribute;Predisposition;Process;Production;programmed cell death ligand 1;Proteins;Publishing;receptor;Renaissance;Research;response;Ribosomes;Role;Signal Pathway;Signal Transduction;Stress;stress granule;success;System;Testing;Therapeutic;Translating;translation factor;Translation Initiation;translational pipeline;Translational Repression;virtual;Virus;Virus Diseases;Work

PROJECT_TITLE: Transcriptional and Translational Mechanisms Governing Beta Cell Function

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Allergic Rhinitis (Hay Fever);Bioengineering;Biotechnology;Clinical Research;Data Science;Digestive Diseases;Eczema / Atopic Dermatitis;Food Allergies;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Microbiome;Networking and Information Technology R&D (NITRD);Nutrition;Pediatric;Prevention

PI_NAMEs: THAKAR, JUILEE  (contact)

PROJECT_TERMS: Affect;Age Months;Allergens;Allergic;Allergic Disease;Allergic rhinitis;Asthma;ATAC-seq;Atopic Dermatitis;atopy;biobank;Bioinformatics;Biological Assay;Biological Markers;biomarker identification;Birth;Blood;Child;Chronic;classification algorithm;Clinical;clinical predictive model;cohort;Collaborations;comparison group;Complex;complex data;computerized data processing;cytokine;Data;data acquisition;Data Analyses;Data Collection;Data Coordinating Center;data integration;data integrity;data management;data sharing;data standards;Data Storage and Retrieval;data submission;Database Management Systems;database of Genotypes and Phenotypes;Databases;Development;Diet;Dimensions;Disease;early childhood;Eczema;Ensure;Environment;Environmental Exposure;Experimental Designs;Exposure to;FAIR principles;Family;Farm;fecal microbiome;Feces;Flow Cytometry;Food;Food Hypersensitivity;gut microbiome;Health;Health Status;high risk;high throughput screening;Human Resources;Hypersensitivity;Immune;Immune signaling;Immune system;Immunity;Immunology;Individual;Infant;infant gut microbiome;Inflammation;Informatics;Infrastructure;insight;Learning;Life;Longitudinal cohort;Measurement;Medical;Mennonite;metabolomics;Metadata;Metagenomics;Methods;microbiome;Modeling;Molecular;Mucous Membrane;multiple data types;novel;Outcome;Output;Participant;Pathway interactions;Phenotype;Play;Population;predictive modeling;Prevalence;Prevention strategy;Primary Prevention;Procedures;programs;Proteome;Proteomics;public repository;Quality Control;Questionnaires;random forest;recruit;Reporting;repository;Reproducibility;Research Personnel;Resource Sharing;response;Risk;Role;sample collection;Sampling;Scheme;Secure;single cell ATAC-seq;Site;Skin;skin barrier;skin microbiome;Software Tools;Standardization;statistical learning;statistics;Structure;success;Surveys;Swab;System;Techniques;Testing;Time;tool;Training;transcriptome;transcriptomics;Umbilical Cord Blood;Universities;Unmarried person;Visit;Work

PROJECT_TITLE: Data Management and Bioinformatics


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Digestive Diseases;Mental Health;Mental Illness

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The current paradigm of laryngopharyngeal reflux (LPR) largely ignores the interplay of psychological processes (e.g., hypervigilance, anxiety) on symptom burden, representing a tremendous missed opportunity to help patients with chronic laryngeal complaints and contributing to suboptimal treatment outcomes. This prospective study will utilize psychometric methods to develop a validated self-report instrument (the laryngeal hypervigilance and anxiety scale [LHAS]) and measure levels of hypervigilance and anxiety across distinct groups of LPR patients identified through our prior discriminant analysis of principal components model. These findings will introduce a novel tool to clinical practice, impact future anticipated clinical trial designs, and ultimately inform multi-pronged care paradigms for LPR inclusive of therapies targeting psychosocial processes.

PI_NAMEs: YADLAPATI, RENA HIREN (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Accounting;Adult;Affective;Anxiety;Behavior;Behavior Therapy;career;Caring;Categories;Chronic;Classification;Clinical;clinical practice;Clinical Trials Design;Cognition;Cognitive;Cognitive Therapy;Combined Modality Therapy;comparison intervention;Consultations;Coughing;Data;Diagnosis;Diagnostic tests;Discriminant Analysis;Disease;Dysphonia;efficacy evaluation;Esophagus;experience;Fundoplication;Future;Gastroesophageal reflux disease;General Population;Goals;Health Care Costs;health related quality of life;healthy volunteer;Heartburn;inhibitor;inhibitor therapy;innovation;instrument;Interview;laryngopharyngeal reflux;Larynx;Measures;Mental Depression;Mental Health;Mentored Patient-Oriented Research Career Development Award;Methods;Modeling;novel;Operative Surgical Procedures;Patient Self-Report;Patients;Phenotype;Physiological;poor health outcome;Principal Component Analysis;Process;programs;Property;Prospective Studies;Proton Pump Inhibitors;psychologic;psychological distress;psychological stressor;Psychometrics;psychosocial;Pump;Quality of life;Questionnaires;Randomized, Controlled Trials;Reflux;Reporting;Research;Research Proposals;Resources;Role;Severities;Sore Throat;Speech;success;Symptom Burden;symptomatic improvement;Symptoms;Syndrome;targeted treatment;therapeutic target;tool;Treatment outcome;treatment response;United States National Institutes of Health;Work

PROJECT_TITLE: Role of Psychological Processes on Symptom Burden in Laryngopharyngeal Reflux

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: RICHMOND

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative The goals of the Health Education Research Opportunities for Teachers (HERO-T) program are to (1) cultivate in teachers the skills needed to conduct cutting edge biomedical research and translate their research experience into curricula for their students and (2) increase student awareness of and exposure to research in the biomedical sciences and foster in them scientific investigation skills. The anticipated outcomes are that teachers who participate in this summer research experience will have improved ability to communicate scientific concepts to their students, have a greater understanding of the applications of science to everyday life, and have improved research and laboratory skills. Students who participate in the program will enhance their awareness of and exposure to biomedicine/ biomedical research and increase their awareness of careers in biomedicine/ biomedical research and cultivate their scientific investigation skills.

PI_NAMEs: DAMAJ, M. IMAD ;EDMONDSON, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: FRIEND, LINDSEY NICOLE

PROJECT_TERMS: Academy;Address;Area;Awareness;Basic Science;Biomedical Research;career awareness;Communication;course development;Data;design;Development;education research;Educational Curriculum;Educational workshop;experience;Exposure to;externship;Face;Faculty;Fostering;Goals;Grant;Health;health disparity;Health education;health goals;high needs schools;High School Student;IACUC;improved;innovation;Instruction;Investigation;Laboratories;learning community;Life;Literature;member;metropolitan;Mission;National Institute of Drug Abuse;Outcome;peer learning;Process;programs;recruit;Research;Research Personnel;Research Training;responsible research conduct;Schools;Science;science teacher;skills;student participation;Students;summer research;symposium;Talents;teacher;Teacher Professional Development;theories;tool;Training;Translating;Underrepresented Populations;Universities;Virginia

PROJECT_TITLE: VCU Health Education Opportunities for Teachers (HERO-T)


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Nanotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: IOWA CITY

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE (RELEVANCE) Repair of large bone defects is a crucial medical challenge and tissue engineering (either using stem/progenitor cells transplantation and/or growth factors, e.g. BMPs) is a promising alternative to autologous bone graft while a number of crucial barriers must be overcome for full therapeutic translation. Through a combinatorial approach utilizing small molecule drugs and tunable and biomimetic scaffolds, this study will develop novel regenerating therapies for treatment of bone defects. This work will not only advance knowledge with regard to regenerative medicine, but accelerate novel strategies for bone repair/regeneration in a range of patients, most particularly the elderly.

PI_NAMEs: SUN, HONGLI  (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Adult;age related;aged;Aging;aging population;angiogenesis;Anti-Inflammatory Agents;Autologous;Autologous Transplantation;Biomimetics;bone;bone aging;Bone Diseases;Bone Matrix;Bone Morphogenetic Proteins;Bone Regeneration;bone repair;Bone Tissue;Bone Transplantation;cell age;cell growth;Cell Transplantation;Cells;Cephalic;chemical conjugate;chemical property;Chitosan;Chronic;clinically relevant;combinatorial;controlled release;cost;cytokine;Defect;Deferoxamine;Drug Delivery Systems;effectiveness evaluation;Elasticity;Elderly;Electrospinning;Endothelial Cells;Engineering;Female;Goals;Growth Factor;HA coating;Healthcare;HIF1A gene;Hormones;Human;human stem cells;Hypoxia;Immobilization;improved;In Situ;In Vitro;Inflammation;Inflammatory;innovation;Iron;Iron Chelation;Irregular Bone;Knowledge;local drug delivery;male;mechanical properties;Mediating;Medical;Mesenchymal Stem Cells;Modeling;Modernization;Molecular;Mus;nanofiber;nanomaterials;Natural regeneration;new therapeutic target;next generation;novel;novel strategies;old mice;Older Population;osteoblast differentiation;Osteogenesis;osteogenic;Patients;Pharmaceutical Preparations;phenylamil;Play;Polymers;Population;Prevalence;Production;Proteins;recruit;Regenerative capacity;Regenerative Medicine;regenerative therapy;Rejuvenation;repaired;Research;restoration;Role;Safety;scaffold;Signal Pathway;Signal Transduction;Signaling Protein;small molecule;Somatotropin;Stem cell transplant;Structure;success;System;Techniques;Tissue Engineering;tissue regeneration;Tissues;translational applications;translational therapeutics;Transplantation;Work

PROJECT_TITLE: Rejuvenating aged bone regeneration by innovative nanomaterials-mediated drug delivery

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Eczema / Atopic Dermatitis;Food Allergies;Microbiome;Nutrition;Pediatric;Prevention

PI_NAMEs: CLEMENTE, JOSE C (contact)

PROJECT_TERMS: Acceleration;Affect;Allergic;Allergic rhinitis;Animal Model;Anti-Allergic Agents;Anti-Inflammatory Agents;Asthma;Atopic Dermatitis;atopy;Bacteria;bacterial community;Bifidobacterium;bile acid metabolism;Bile Acids;biobank;Bioinformatics;Biological Markers;biomarker identification;Catabolism;Child;Childhood;Chronic;cohort;Colon;Communities;Consultations;Data Analyses;data integration;data management;Development;Dietary Fiber;Disease;Early identification;Epithelium;Exposure to;Farm;fecal metabolome;Fermentation;Food Hypersensitivity;Future;Genes;Goals;gut microbiome;Health;high risk infant;Hypersensitivity;Immune;Immune system;Immunity;Immunocompetence;Immunologic Markers;improved;Indoles;Infant;interleukin-22;Intervention;Intestinal permeability;Lactic acid;Lamina Propria;Life;Life Style;Measures;Medical;Mennonite;Metabolism;metabolome;metabolomics;Metadata;Methods;microbial;microbiome;microbiome composition;microbiome research;novel;oral tolerance;Outcome;Pathway interactions;Permeability;Play;Prevalence;Prevention strategy;Primary Prevention;Production;Property;Publishing;rational design;Regulatory T-Lymphocyte;Risk;Risk Reduction;Role;Sampling;Shotgun Sequencing;skin barrier;skin microbiome;suburb;Symptoms;T cell differentiation;Taxonomy;Testing;Time;Tryptophan;Tryptophan Metabolism Pathway;Urban Community;Volatile Fatty Acids;Work

PROJECT_TITLE: Gut Microbial Factors in Farming Lifestyle and Allergic Sensitization


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

PHR: Project Narrative There is a critical shortage of individuals trained in Clinical Pharmacology - the science of studying drugs in man. The Clinical Pharmacology Fellowship Program at Vanderbilt has been highly successful in producing well trained leaders in the field. The proposed program seeks to provide state-of-the art training for the next generation of clinical pharmacologists.

PI_NAMEs: KNOLLMANN, BJORN C (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Clinical Pharmacology;Training Programs

PROJECT_TITLE: Clinical Pharmacology Training Program


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Pediatric

ORG_CITY: TEMPE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative Guided by an innovative conceptual model incorporating perspectives from the migration and child development literatures, this project examines multiple child- and environment-level mechanisms through which the migration of family members is associated with left-behind children’s social competence and psychological adjustment problems. New knowledge about migration’s costs and benefits can assist families in settings with a high prevalence of labor migration as they adapt to the changes that migration brings to family members’ relationships, caregiving, and households’ resources. This research can also help policy makers anticipate the challenges that migration poses to children’s mental health and positive adjustment, and inform policies and interventions aimed at supporting left-behind family members and reducing problems such as depression, anxiety, aggression, rule-breaking, and substance use.

PI_NAMEs: SPINRAD, TRACY LORRAINE (contact)

PROGRAM_OFFICER_NAME: JEKIELEK, SUSAN

PROJECT_TERMS: 17 year old;Address;Adolescence;Adult;Affect;Age;age effect;age group;Aggressive behavior;Alcohol consumption;Anxiety;Area;Behavior Control;Caregivers;caregiving;Characteristics;Child;Child Development;Child Mental Health;Child Rearing;Communities;Competence;Complex;Costs and Benefits;Country;Coupled;Cross-Sectional Studies;Data;Data Collection;data portal;Developed Countries;Development;Dimensions;Drug usage;Economics;Emotional;Environment;expectation;experience;Family;Family Leave;Family member;family structure;father role;Father-Child Relations;Fathers;Goals;High Prevalence;Household;Household and Family;improved;Industrialization;innovation;International;Intervention;Interview;Investigation;Knowledge;Labor Migrations;Left;Life Cycle Stages;Literature;Measures;Mediating;Mediator;Mental Depression;Migrant;migration;Modeling;Monitor;Nepal;Nonmigrant;Outcome;Outcome Measure;Parent-Child Relations;Parents;Personal Satisfaction;Policies;Policy Maker;primary caregiver;Psychological adjustment;Punishment;Recording of previous events;Research;Resources;Rights;Role;Sampling;Schools;sex;social;Social Adjustment;social skills;Socialization;substance use;Time;transition to adulthood;UNICEF;Well in self;Work

PROJECT_TITLE: Family context, socialization, and children's socio-emotional development

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative (Relevance) Time-of-flight positron emission tomography is the standard of care in nuclear imaging for a broad range of diseases, from numerous types of cancer to neurological and cardiovascular disorders. To achieve a good spatial resolution and image quality, an excellent time and energy resolution are required. In this project, we aim to demonstrate a novel way to improve both simultaneously by exploiting the information carried by the wavelength of the optical photons generated in scintillator materials.

PI_NAMEs: SEO, YOUNGHO  (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TERMS: absorption;accurate diagnosis;Aluminum;Bismuth;cancer type;Cardiovascular Diseases;Chlorides;Classification;cost effective;Coupled;design;Detection;detector;Diagnosis;Disease;Disparity;Dose;Electrons;Ensure;Event;frontier;Future;Gadolinium;Gallium;Gamma Rays;Germanium;Goals;Grant;high reward;high risk;Hybrids;Image;Image Enhancement;imaging capabilities;imaging modality;improved;Lead;Light;light emission;Malignant Neoplasms;Measures;millimeter;Modality;Modernization;Motivation;nanosecond;Nature;Nervous System Disorder;new technology;next generation;Noise;novel;nuclear imaging;optical spectra;Optics;Oxides;Patients;Performance;photon-counting detector;Photons;Positron;Positron-Emission Tomography;prototype;quantum;Radioactive;Resolution;Safety;Signal Transduction;standard of care;success;System;Techniques;Technology;Thallium;Time;transmission process;Work

PROJECT_TITLE: Leveraging ultra-fast Cherenkov emission in scintillator-based TOF-PET by exploiting photon wavelength classification

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Neurosciences;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Vector-Borne Diseases;Zika Virus

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative Although the devastating consequences of Zika virus infection in the fetal brain have been known since the 2016 outbreak in the Americas, we still do not fully understand how the virus causes microcephaly. We hypothesize that a branch of the immune system known as innate immunity-- which is important for controlling viral infection-- is not fully functional in the fetal brain. Our experiments will determine how innate immunity develops and functions in the fetal brain, allowing us to design treatments that protect the growing infant and brain from Zika infection.

PI_NAMEs: STOKES, CALEB  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Affect;Americas;Area;Attenuated;Award;Bioinformatics;Biological Models;Brain;career development;Career Mobility;Cell Differentiation process;cell type;Cells;Central Nervous System;Cerebrum;Clustered Regularly Interspaced Short Palindromic Repeats;Communicable Diseases;congenital zika syndrome;Defect;Detection;Development;Development Plans;differential expression;Disease Outbreaks;embryonic stem cell;Encephalitis;ES Cell Line;experimental study;Faculty;Family member;fetal;Flavivirus;Flow Cytometry;Gene Expression;gene induction;gene network;Genes;Goals;Human;IFITM1 gene;Immune;Immune signaling;Immune system;Immunology;Impairment;in utero;In Vitro;Infant;Infection;Injury;innate immune mechanisms;Innate Immune Response;Innate Immune System;insight;Interferons;Invaded;Knock-out;Life;Link;Mediating;Mentors;Microcephaly;Modeling;mosquito-borne;Natural Immunity;nerve stem cell;nervous system development;neural;neurogenesis;Neuroglia;Neuronal Differentiation;Neurons;Neurophysiology - biologic function;Neurosciences;novel strategies;Organoids;overexpression;Pathogen detection;Pattern recognition receptor;Predisposition;Pregnancy;Production;progenitor;Proteins;Protocols documentation;receptor;receptor expression;receptor function;Receptor Signaling;Resistance;Resources;response;Role;self-renewal;Signal Induction;Signal Transduction;single-cell RNA sequencing;stem cell differentiation;System;Techniques;Testing;Therapeutic Intervention;therapeutic target;therapy design;Time;Toll-like receptors;Training;Tretinoin;Up-Regulation;Viral;viral detection;Viral Encephalitis;viral RNA;Virus;Virus Diseases;West Nile virus;Work;Zika Virus;ZIKV infection

PROJECT_TITLE: Innate Immunity of Zika Virus Infection In Human Neural Progenitors

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Heart Disease;Heart Disease - Coronary Heart Disease;Nutrition

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative (3 sentences) We seek funding to complete the Trial to Assess Chelation Therapy 2 (TACT2), an ongoing multicenter US- Canada randomized controlled factorial trial in 1000 post-MI patients with diabetes, testing whether 40 intravenous edetate disodium-based infusions or placebo infusions and high-dose oral multivitamins or oral placebo reduce recurrent ischemic cardiac events. There is a biorepository for urine and blood. The study has completed enrollment and seeks funding for 2.5 additional years to complete infusions, follow-up, and closeout.

PI_NAMEs: ANSTROM, KEVIN J;MARK, DANIEL B (contact)

PROGRAM_OFFICER_NAME: WEBER, WENDY J

PROJECT_TERMS: active method;Age Years;biobank;Blood;Canada;Cardiovascular Diseases;Cardiovascular system;Cessation of life;chelation;Chelation Therapy;Clinical;clinical practice;Clinical Research;clinically significant;Complementary and alternative medicine;Coronary;Coronary Arteriosclerosis;Creatinine;Data Analyses;Data Coordinating Center;Databases;design;Diabetes Mellitus;Disease-Free Survival;DNA;Doctor of Philosophy;Dose;economic evaluation;Enrollment;Etiology;Event;follow-up;Funding;Future;Guidelines;Hospitalization;improved;Infusion procedures;insight;Intravenous;Laboratories;Medical center;Metals;mortality;Multivitamin;Multivitamins/Minerals;Myocardial Infarction;Myocardial Ischemia;National Center for Complementary and Integrative Health;National Heart, Lung, and Blood Institute;New York City;novel;Oral;Outcome;Patients;Placebos;primary endpoint;Principal Investigator;Public Health;Public Health Schools;Publications;Publishing;Randomized;randomized placebo controlled trial;Recurrence;Regimen;Relative Risks;Reporting;Request for Applications;Research Institute;response;revascularization;Risk Reduction;Serum;Site;Stroke;Subgroup;Telephone;Testing;Time;toxic metal;treatment arm;treatment effect;treatment group;treatment strategy;trial comparing;United States Food and Drug Administration;United States National Institutes of Health;Universities;Urine;vitamin therapy

PROJECT_TITLE: Trial to Assess Chelation Therapy 2 (TACT2) DCC Competing Renewal


NIH_SPENDING_CATS: Asthma;Clinical Research;Digestive Diseases;Eczema / Atopic Dermatitis;Food Allergies;Genetics;Lung;Microbiome;Nutrition;Pediatric;Prevention

PROJECT_TERMS: Allergens;Allergic;Allergic Disease;Anti-Allergic Agents;Asthma;Atopic Dermatitis;atopy;Bifidobacterium;Biological Markers;Birth;Blood;Cells;Clinical Data;clinical development;cohort;Communities;Constitution;cytokine;Development;Disease;Disease Outcome;early detection biomarkers;Enrollment;Epigenetic Process;epigenome;Epithelial Cells;Epithelium;experience;Extrinsic asthma;Family;Farm;Feces;Flow Cytometry;Food;food antigen;Food Hypersensitivity;Frequencies;functional outcomes;gastrointestinal;gastrointestinal epithelium;Gene Expression;Generations;Genetic Transcription;Goals;gut microbiome;high risk;Homing;IgE;Immune;Immunity;Immunologic Markers;Immunophenotyping;In Vitro;in vivo;Individual;infancy;Infant;infant gut microbiome;Inflammatory;Intervention;intestinal barrier;intestinal epithelium;Intestinal permeability;KLRB1 gene;Life Style;Lipopolysaccharides;Maintenance;Measures;Mediating;Memory;Mennonite;microbial;Modification;monocyte;Myeloid Cells;novel;Outcome;Pathogenicity;Permeability;Phenotype;Population;Prevention strategy;Proliferating;receptor;Regulatory T-Lymphocyte;Reproducibility;response;Risk;Role;Sampling;School-Age Population;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Site;Skin;Sterility;Stimulus;T cell differentiation;T-Lymphocyte;Testing;TLR4 gene;Training;transcriptome;Umbilical Cord Blood;Viral;Water;Work

PROJECT_TITLE: Innate and Adaptive Immune Markers in Farming Lifestyle and Early Atopic Diseases


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Prevention;Social Determinants of Health;Telehealth

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: This study uses a Type 1 effectiveness-implementation hybrid approach to swiftly examine program effectiveness while simultaneously determining implementation uptake of a multi-level intervention that builds the resilience of community-based child care centers during and post- public health crises such as COVID-19. This project has the potential to provide valuable information on how to rapidly support the immediate psychosocial and safety needs of teachers and children, and strengthen the readiness for childcare centers to adapt to future crises. If we can equip childcare centers serving low-income, ethnic minority communities with strategies to maintain quality in the face of adversity, we can in turn support teachers, parents, and young children and help keep society functioning during global challenges.

PI_NAMEs: JENT, JASON F;NATALE, RUBY ANN (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Address;Adult;Affect;Anger;Anxiety;Area;attentional control;Attitude;Behavior;Belief;care systems;Child;Child Behavior;Child Care;Child Development;Child Health;Child Support;Chronic;Cluster randomized trial;Communication;Communities;community intervention;Community Networks;Consultations;contextual factors;Control Groups;coping;County;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;Data;Development;Disasters;Distress;early childhood;Education;Educational process of instructing;effectiveness evaluation;effectiveness study;effectiveness testing;effectiveness/implementation hybrid;effectiveness/implementation trial;Emotional;Environment;Environmental Risk Factor;ethnic diversity;ethnic minority;Evaluation;executive function;Exhibits;experience;Family;Family Characteristics;follow-up;Future;Goals;group intervention;Guidelines;high risk;HIV;Hurricane;hybrid type 1 design;implementation barriers;implementation evaluation;implementation/effectiveness;improved;Individual;innovation;Intervention;Link;Long-Term Effects;Low income;Measures;Mediating;Mental Depression;Mental Health;Methods;Minority;minority communities;Modeling;National Institute of Child Health and Human Development;Needs Assessment;Nursery Schools;obesity prevention;Occupations;Outcome;pandemic disease;pandemic impact;Parents;Personal Satisfaction;Policies;Poverty;preventive intervention;primary outcome;Problem behavior;Program Effectiveness;programs;promote resilience;psychologic;psychosocial;Psychosocial Assessment and Care;psychosocial development;psychosocial outcome;Public Health;public health intervention;racial diversity;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Recovery;Research;Research Priority;resilience;Resources;Risk;risk mitigation;Robot;Role;Safety;scale up;Self Care;Self Efficacy;social factors;Social isolation;Societies;Stress;Support System;System;teacher;teleconsultation;telepresence;Testing;Time;Toddler;Trauma;Uncertainty;UNICEF;uptake;vaccine acceptance;virtual;Well in self;ZIKA

PROJECT_TITLE: Jump Start+:COVID Support to improve resiliency and mitigate risks in childcare centers serving children from low-income ethnic minority backgrounds.

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROSURGERY

PHR: PROJECT NARRATIVE  Different areas of the brain are composed of unique cell types and connectivity patterns that subserve their unique functional roles, and disruption of areal patterning during development can lead to neurologic and neuropsychiatric disorders such as autism and schizophrenia. Recent studies have implicated a role for retinoic acid, derived from Vitamin A, in patterning of the cerebral cortex, and this proposal will explore the mechanism by which this areal specification occurs. These experiments will generate foundational knowledge about the mechanisms of areal specification in the brain, and may help explain genetic susceptibility to neurodevelopmental disorders associated with abnormal arealization.

PI_NAMEs: CADWELL, CATHRYN RENE (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Advisory Committees;Anatomy;Animal Model;Animals;Anterior;Area;area striata;autism spectrum disorder;Automobile Driving;Axon;Binding;Biological Assay;Brain;California;career;career development;Cell Lineage;cell type;Cells;Cerebral cortex;Cerebrum;Clinical;cognitive ability;cognitive process;college;Committee Members;Communication;comparative;Data;Decision Making;Development;Development Plans;DNA Binding;Doctor of Philosophy;Enhancers;Environment;Epigenetic Process;Evolution;excitatory neuron;Experimental Models;experimental study;Exposure to;Family;Fellowship;FGF8 gene;Fibroblast Growth Factor;Foundations;Future;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic Markers;Genetic Predisposition to Disease;Geniculate body structure;genome sequencing;genome-wide;genomic data;Goals;Grant;Human;human induced pluripotent stem cells;Immunohistochemistry;In Vitro;insight;Knowledge;Laboratories;large scale data;Lateral;Learning;Location;Mediating;Medicine;member;Mentors;Mentorship;Modeling;Molecular;molecular phenotype;morphogens;Motor;Mus;neonatal mice;nerve stem cell;Nervous System Disorder;neural;Neurodevelopmental Disorder;Neuroglia;Neurons;neuropathology;neuropsychiatric disorder;Neurosciences;Nuclear;Nuclear Receptors;organoid transplantation;Organoids;Pathologic Processes;Pathology;Patients;Pattern;pharmacologic;Phenotype;Physicians;Play;pleasure;postmitotic;Prefrontal Cortex;prenatal;Preventive;Primates;Process;progenitor;programs;Prosencephalon;protein expression;Publishing;Radial;RARB gene;RARG gene;receptor binding;Regulator Genes;Regulatory Element;Reporter;Research;Resolution;response;Retinoic Acid Binding;Retinoic Acid Receptor;Role;San Francisco;Schizophrenia;Shapes;Short-Term Memory;Signal Pathway;Signal Transduction;skills;Specific qualifier value;Techniques;Testing;Thalamic structure;Therapeutic;Tissues;Training;transcription factor;Transplantation;Tretinoin;Universities;Untranslated RNA;Vitamin A;whole genome;Work;Writing;Xenograft procedure

PROJECT_TITLE: The role of retinoic acid signaling in patterning the human cerebral cortex


NIH_SPENDING_CATS: Clinical Research;Eczema / Atopic Dermatitis;Food Allergies;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Nutrition;Pediatric;Prevention

PI_NAMEs: GUTTMAN, EMMA  (contact)

PROJECT_TERMS: Age;Allergens;Allergic;Allergic Disease;Allergic inflammation;Antibiotics;Atopic Dermatitis;atopy;Attenuated;Automobile Driving;Bathing;Biological;Biological Markers;Biopsy;Birth;Characteristics;Child;Childhood;Classification;cohort;Communities;comparison control;Consumption;Cutaneous;cytokine;Data;Developed Countries;Development;Disease;early childhood;early detection biomarkers;early onset;Environmental Exposure;Epithelium;Exposure to;Family;Farm;Farming Community;Food Hypersensitivity;Frequencies;Genes;Goals;Healthcare;high risk;Home;Hypersensitivity;Immune;Immunity;Immunologic Markers;Impairment;Infant;Inflammation;Inflammatory;Life;Life Style;Livestock;Longitudinal Studies;Measures;Mennonite;Methods;microbial;microbiome;microbiome analysis;Milk;minimally invasive;Molecular;Molecular Profiling;novel;Pathway interactions;Permeability;prevent;Prevention;Prevention strategy;Primary Prevention;Production;protective effect;Proteins;Proteomics;Public Health;respiratory;Reverse Transcriptase Polymerase Chain Reaction;Ribosomal RNA;Risk;Role;Sampling;Severities;Skin;skin barrier;skin biopsy;Skin Care;Skin colonization;skin microbiome;Societies;socioeconomics;Staphylococcus aureus;Swab;T-Lymphocyte;Testing;Therapeutic;time interval;transcriptome sequencing;transcriptomics;TSLP gene;unpasteurized;Water

PROJECT_TITLE: Role of Skin Barrier and Immune Alterations in Allergic Sensitization


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: In full response to RFA RFA-AI-20-004, we will study the mechanistic aspects of the combination of NKT cell adjuvants with TLR ligands. This particular association has been shown to be highly effective in producing anti- glycan antibody responses and might lead to anti-bacterial protection after a single injection.

PI_NAMEs: TEYTON, LUC  (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Adjuvant;Adjuvanticity;Affinity;Agonist;alpha Tocopherol;aluminum sulfate;Animal Model;Anti-Bacterial Agents;Antibodies;Antibody Response;Antigens;Attenuated;autism spectrum disorder;B-cell receptor repertoire sequencing;B-Lymphocytes;Biological;Biological Models;Categories;CD4 Positive T Lymphocytes;cell type;Cells;Cervarix;Child;Childhood;combinatorial;Complex;Conjugate Vaccines;Consensus;Coupled;design;dosage;Dose;Endosomes;Europe;False Allegation;FDA approved;Formulation;Fright;Genetic Transcription;Goals;Guillain Barré Syndrome;Helper-Inducer T-Lymphocyte;Hepatitis B Vaccines;Hygiene;Immune response;Immunity;Immunology;improved;Industry;infectious disease treatment;Influenza A Virus, H1N1 Subtype;influenza infection;influenza virus vaccine;Injections;Knowledge;Ligands;Measures;Memory;MF59;Microbe;Molecular;nanomolar;Narcolepsy;neglect;Papillomavirus;pathogen;pathogenic microbe;Perception;Pertussis;Pertussis Vaccine;Phase;Polysaccharides;prevent;Preventive treatment;protein expression;prototype;Reaction;receptor;Receptor Activation;Research;response;Safety;Saponins;Serotyping;side effect;single cell technology;social stigma;Squalene;Streptococcus pneumoniae;Subunit Vaccines;synergism;Synthesis Chemistry;TLR7 gene;Toll-like receptors;Toxic effect;Toxin;Tween 80;uptake;Vaccination;Vaccine Design;vaccine formulation;Vaccines

PROJECT_TITLE: Mechanistic Studies of Combination Adjuvants to Target B Cells in Vaccines


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: MADISON

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative/Relevance This project will investigate the impact of aging on sex steroid hormones in benign prostatic hyperplasia (BPH) progression. In better defining the mechanisms of age-related disease progression due to altered steroid hormone metabolism, the reestablishment of steroid hormone homeostasis could provide a novel, effective treatment of BPH.

PI_NAMEs: LIU, TERESA  (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Affect;Age;age effect;age related;age related changes;age-related disease;Aging;aging related;aging related disease;aging reversal;androgen biosynthesis;Androgens;Animal Model;Apoptosis;Area;Benign Prostatic Hypertrophy;Biological Assay;Biological Markers;biomarker identification;bisulfite sequencing;career;career development;Catabolism;Cell Line;Chromatin;chromatin remodeling;Clinical;clinical efficacy;clinical examination;Combined Modality Therapy;Complex;CRISPR/Cas technology;Data;design;Development;Disease;Disease Progression;Disease stratification;DNA Methylation;effective therapy;effectiveness evaluation;Elements;Environment;Enzymes;Epigenetic Process;epigenetic regulation;Equilibrium;ESR1 gene;Estrogen Receptor 2;Estrogen Receptors;Estrogens;Etiology;experience;Functional disorder;gain of function;Gene Expression;Genes;genome-wide;Glycols;Goals;Gonadal Steroid Hormones;Grant;Homeostasis;Hormone Receptor;hormone regulation;Hormones;Human;Hyperplasia;Immunohistochemistry;improved;In Vitro;in vivo;Increased frequency of micturition;insight;Knockout Mice;Ligands;loss of function;Lower urinary tract;lower urinary tract symptoms;male;Maps;Mediating;men;Mentors;Metabolism;Methods;Methylation;minimally invasive;Modeling;Modification;Molecular;molecular modeling;Monitor;mouse model;Mus;novel;novel drug combination;old mice;oxysterol 7-alpha-hydroxylase;Patients;Peripheral;Pharmaceutical Preparations;Pharmacotherapy;Positioning Attribute;Production;Proliferating;promoter;Prostate;Prostatic Diseases;prototype;Quality of life;receptor;Receptor Activation;receptor expression;Research;Research Personnel;Resolution;Sampling;Selective Estrogen Receptor Modulators;Signal Transduction;Stanolone;Steroid biosynthesis;steroid hormone;steroid hormone metabolism;steroid hormone receptor;steroid metabolism;Steroids;Symptoms;Testing;Testosterone;therapy resistant;Tissues;Training;Treatment Cost;Treatment Effectiveness;Treatment Efficacy;Universities;urinary;Urologic Diseases;Wisconsin;Work

PROJECT_TITLE: Impact of age on altered steroidogenesis and estrogen receptor activation in benign prostatic hyperplasia progression

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Biological Aging Study Section[NIA-B]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Back Pain;Bioengineering;Biomedical Imaging;Chronic Pain;Clinical Research;Neurosciences;Pain Research

ORG_CITY: Columbus

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Lumbar spine imaging has become ubiquitous in the standard course of care for low back pain (LBP); however, offers only a qualitative assessment of spinal anatomy often not predictive of painful conditions. Magnetic resonance elastography (MRE) is a non-invasive technique that allows the in-vivo measurement of tissue's mechanical properties and has been described as a way to visually palpate internal tissues. The long-term objective of this work is to integrate MRE with other advanced MR imaging parameters into a “patient specific” clinical tool that can identify damage and quantify the functional consequences of disease and treatments for LBP.

PI_NAMEs: KOLIPAKA, ARUNARK ;WALTER, BENJAMIN A. (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: 3-Dimensional;Address;Advisory Committees;anatomic imaging;Anatomy;Area;Biological Markers;Biomechanics;Cadaver;Caring;Chronic low back pain;Clinical;clinical imaging;clinical implementation;Custom;Data;Data Collection;Defect;Detection;disability;discogenic pain;Disease;Early Diagnosis;Echo-Planar Imaging;efficacy evaluation;Engineering;Future;Gel;Goals;Grant;Growth;Human;Image;Imaging Techniques;improved;In Vitro;in vivo;in vivo evaluation;Individual;injured;Injury;Intervention;Intervertebral disc structure;intervertebral disk degeneration;intervertebral disk surgery;Lesion;Low Back Pain;Magnetic Resonance Elastography;Magnetic Resonance Imaging;Materials Testing;Measurement;mechanical behavior;mechanical properties;Mechanics;Methods;Modulus;Musculoskeletal;Nerve;Noise;non-invasive imaging;novel;Operative Surgical Procedures;Orthopedic Surgery;Pain;Pain management;pain patient;Painless;Palpation;patient stratification;Patients;Persons;Phase;Process;prognostic;Property;Proteoglycan;Radial;Radiology Specialty;Recommendation;Research;Risk;Scanning;Sensitivity and Specificity;Sepharose;Signal Transduction;Slice;soft tissue;Spinal;spinal disk injury;Stratification;Structure;Techniques;Time;Tissues;tool;United States National Institutes of Health;Validation;Variant;Vertebral column;viscoelasticity;Visual;Water;Work

PROJECT_TITLE: Magnetic Resonance Elastography as a Personalized Assessment of Intervertebral Disc Mechanics

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Nutrition

PHR: Title: Commensal bacteria resilience mechanisms in the inflamed intestine PROJECT NARRATIVE  Marked decreases in essential micronutrients such as iron perturb the gut microbial community during intestinal inflammation, depleting beneficial commensals. Commensal resilience is central to maintaining the overall microbiota structure and functions in the face of perturbations such as nutritional depletion; however, there is a crucial knowledge gap in the underlying mechanisms of resiliency. The overarching goal of this proposal is to understand how the prevalent bacterium Bacteroides thetaiotaomicron survives iron starvation during inflammation, thereby elucidating fundamental mechanisms governing microbiota resilience and commensal-pathogen iron competition in the gut.

PI_NAMEs: ZHU, WENHAN  (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Affinity;Animal Disease Models;Animal Model;Bacteria;Bacterial Model;Bacteroides thetaiotaomicron;Bacteroidetes;beneficial microorganism;Binding;Binding Proteins;Biological Availability;Colitis;combat;commensal bacteria;coping;Couples;Coupling;Data;Dimensions;Disease;dysbiosis;enteric pathogen;Equilibrium;Expenditure;experimental study;extracellular;fitness;Goals;gut inflammation;gut microbes;gut microbiome;gut microbiota;Health;Homeostasis;Human;In Vitro;in vivo;Inflammation;innovation;insight;Intestines;Iron;Iron Chelating Agents;Iron Chelation;iron metabolism;Iron-Binding Proteins;Knowledge;LCN2 gene;Lipoproteins;Mediating;member;Membrane;Microbe;microbial;microbiome;microbiota;Micronutrients;Modeling;Molecular;Nutritional;Nutritional Immunity;Organism;pathogen;pathogenic bacteria;Play;Predisposition;prevent;Process;receptor;Regulation;Reporting;Research;Research Project Grants;resilience;response;Role;Salmonella;Salmonella typhimurium;Series;Shapes;Siderophores;Small RNA;Starvation;Stress;Structure;Surface;Testing;Untranslated RNA;uptake;Vesicle;Work

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: CK

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: National Center for Emerging and Zoonotic Infectious Diseases

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: Core Project Narrative/ Relevance We designed projects to protect people from catching hard-to-treat germs in all types of healthcare facilities: nursing homes, long-term ventilator facilities, and hospitals. Diverse interventions are needed in all settings, so we will evaluate how a patient’s own microbes can protect them or may make them vulnerable, learn how bugs spread between people using advanced genetic analyses, facilitate data exchange among facilities, and develop measures of antibiotic use across facilities.

PI_NAMEs: HAYDEN, MARY KATHERINE (contact);TRICK, WILLIAM E

PROJECT_TITLE: CK20-004, Chicago Prevention and Intervention Epicenter III (CPIE-III)


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The Washington University/ BJC Prevention Epicenter performs research to prevent healthcare associated infections and antibiotic resistance in healthcare settings and the community. We do studies with large administrative data, electronic health records, patients and biospecimens. We develop and test Interventions to improve antibiotic use, & disinfection methods, & identify new biomarkers to reduce antibiotic resistance, infections and improve public health.

PI_NAMEs: KWON, JENNIE H (contact)

PROJECT_TITLE: CK20-004, WASHINGTON UNIVERSITY & BJC EPICENTER TO PREVENT HEALTHCARE ASSOCIATED INFECTIONS & ANTIBIOTIC RESISTANCE


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

ORG_CITY: STANFORD

ORG_DEPT: PHYSICS

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative RNA-binding proteins (RBPs) control most aspects of post-transcriptional gene regulation and cause several types of human cancers when mutated, which disrupts their interactions with many different RNAs. Currently, it is not well understood how RBPs are organized to regulate the expression of the RNAs they bind, and which specific domains within them have regulatory potential that is sensitive to mutation. In this work, I will develop and use a high-throughput recruitment assay to identify functional ‘effector’ domains within RBPs, link them to their molecular and cellular mechanisms of regulating RNA, and determine how mutations within them lead to cancer developmen.

PI_NAMEs: THURM, ABBY  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Affect;Amino Acids;Apoptosis;Area;Binding;Binding Proteins;Binding Sites;Bioinformatics;Biological Assay;Cancer Etiology;Catalytic Domain;Cells;Classification;combinatorial;Coupling;Dependence;Deposition;Detection;Development;Disease;Elements;Enzymes;Gene Expression;Gene Expression Regulation;genetic regulatory protein;genetic signature;Genetic Transcription;Health;high throughput screening;Homeostasis;Human;improved;Individual;insight;Invaded;Investigation;knock-down;Lead;Link;Location;Malignant - descriptor;Malignant Neoplasms;Measurement;Mediating;Mesenchymal;Methodology;Methods;Modification;Molecular;Multiple Partners;mutant;Mutate;Mutation;mutation screening;Oncogenes;Oncogenic;overexpression;Pathogenesis;Pathway interactions;Phenotype;Positioning Attribute;Post-Transcriptional Regulation;posttranscriptional;Proliferating;protein expression;protein function;Protein Region;Proteins;recruit;Regulation;Reporter;Reporter Genes;Resources;RNA;RNA Binding;RNA Decay;RNA Processing;RNA Recognition Motif;RNA-Binding Proteins;RNA-Protein Interaction;Small RNA;stoichiometry;synthetic construct;targeted treatment;Tertiary Protein Structure;Testing;therapeutic development;Transcript;Transcriptional Regulation;Translations;Tumor Suppressor Genes;tumorigenesis;Variant;Work;Writing

PROJECT_TITLE: High-Throughput Measurements of RNA-Mediated Regulation of Gene Expression and Oncogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


NIH_SPENDING_CATS: Lung

PHR: Project Narrative This work will define new requirements for classical dendritic cell type-2 (cDC2) positioning, homeostasis and function in spleen and lung. The work will establish the role of the CD97 adhesion-G-protein coupled receptor pathway in splenic cDC2s using flow cytometric, cell signaling and imaging approaches. Studies in EBI2 conditional knockout mice and mice unable to make oxysterols that function as EBI2 ligands will determine how this chemoattractant system determines lung cDC2 distribution and function.

PI_NAMEs: CYSTER, JASON G (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: adaptive immune response;Adhesions;Allergic;Allergic Disease;allergic response;Antibody Response;Antigen Presentation;Antigen-Presenting Cells;Antigens;B-Lymphocytes;Behavior;Blood;blood filter;CD97 gene;cell motility;cell type;Cells;cellular imaging;Chemotactic Factors;conditional knockout;Couples;CRISPR/Cas technology;Critical Pathways;Cues;Dendritic Cells;enzyme deficiency;Epithelium;Erythrocytes;Family member;fMet-Leu-Phe receptor;G-Protein-Coupled Receptors;Generations;Grant;Helper-Inducer T-Lymphocyte;Heterotrimeric GTP-Binding Proteins;Homeostasis;Image;imaging approach;Immune response;immune system function;in vivo;Knockout Mice;Ligands;Location;Lung;Lung Diseases;Lung immune response;Lymphocyte;Lymphoid Tissue;Maintenance;mechanotransduction;Mediating;migration;Molecular;Mus;mutant;novel;Organ;pathogen;pathogen exposure;Pathway interactions;Positioning Attribute;receptor;Reporter;response;Role;screening;secondary lymphoid organ;Sentinel;shear stress;Signal Pathway;Signal Transduction;Site;Source;Spleen;Surface;System;T-Lymphocyte;Th2 Cells;Therapeutic;Tissues;transcription factor;two photon microscopy;Work

PROJECT_TITLE: B lymphocyte Migration and Homeostasis

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Autoimmune Disease;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Disease;Rare Diseases

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Inflammation contributes to many diseases including autoimmunity and acute liver injury. These diseases involve unique forms of inflammation regulated by RIPK1, which can promote or inhibit inflammation in a context and cell type specific manner. The goal of this proposal is to determine how RIPK1 kinase mediates inflammation that drives human disease.

PI_NAMEs: KELLIHER, MICHELLE ALICE (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Acute;acute liver injury;AGFG1 gene;Anti-Inflammatory Agents;Apical;Apoptosis;Autoantibodies;Autoimmune;Autoimmune Hepatitis;Autoimmunity;autoinflammatory;Binding;Bone Marrow;Cell Cycle;Cell Death;Cell Death Signaling Process;Cell membrane;Cell Membrane Permeability;cell type;Cells;Chimera organism;chronic inflammatory disease;Complex;Concanavalin A;cytokine;Cytoprotection;Data;Dendritic Cells;Development;Disease;disease model;DNA;Genetic;Genetic study;Goals;Hematopoietic;Hepatocyte;Homeostasis;human disease;Immune;Immune signaling;Immune system;Immune System Diseases;immunogenic;Immunologic Receptors;immunoreaction;improved;Incidence;Infection;Inflammation;Inflammatory;inhibitor;Injury;innate immune sensing;innovation;Interferons;kinase inhibitor;Knockout Mice;Ligation;Liver;liver inflammation;liver injury;Lupus;Mediating;Modeling;Molecular;mouse genetics;mouse model;Mus;NF-kappa B;novel;Nucleic Acid Binding;Nucleic Acids;Outcome;Pathway interactions;Patients;Pattern;Phosphorylation;Phosphotransferases;Plant Lectins;prevent;Protein Deficiency;Protein Kinase Interaction;Receptor-Interacting Protein;reconstitution;Research;restraint;RIPK3 gene;RNA;Role;scaffold;sensor;Signal Transduction;Stimulator of Interferon Genes;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;Therapeutic;tissue injury;Tissues;TNF gene;Toll-like receptors;Tumor Necrosis Factor Receptor;Viral;Viral hepatitis;Work;Workplace;Z-DNA Binding Protein;Z-Form DNA

PROJECT_TITLE: Rip Proteins in Innate Immune Signaling

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE The research proposed in this application will lead to greater understanding of how stress and damage related to the immune response is mitigated. Such knowledge is relevant to public health because it will lead to the potential manipulation of this response to the patient’s advantage in the treatment of infections and autoimmune disorders.

PI_NAMEs: GARSIN, DANIELLE A (contact)

PROJECT_TERMS: Address;Affect;Animals;Anti-Inflammatory Agents;ATP phosphohydrolase;Autoimmune Diseases;Bacterial Infections;biological adaptation to stress;Caenorhabditis elegans;Chemicals;Communicable Diseases;Complex;Cytoplasm;Cytoprotection;Data;Drug Metabolic Detoxication;Endoplasmic Reticulum Degradation Pathway;Ensure;Exposure to;Family;GATA1 gene;Genes;Genetic Transcription;Goals;Human;Immune;Immune response;Infection;Inflammatory Response;innovation;insight;interest;Intestines;Investigation;Knowledge;Laboratories;Lobular Neoplasia;Mammals;member;Membrane;Modeling;NADPH Oxidase;novel;nuclear factor-erythroid 2;Orthologous Gene;Oxidative Stress;pathogen;pathogen exposure;Pathogenicity;Pathology;Pathway interactions;Patients;pharmacologic;prevent;Process;Production;programs;protective effect;Protein Family;Public Health;Publishing;Reactive Oxygen Species;Regulation;Research;Resistance;response;RNA Interference;Role;Side;Stress;Therapeutic;trafficking;transcription factor

PROJECT_TITLE: Response to Immune Associated Stress


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Chronic Pain;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project narrative The overall goal of this project is to determine the mechanisms of mucosal host defense coordinated by sensory nociceptive neurons during enteric bacterial infection.

PI_NAMEs: REARDON, COLIN  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Ablation;adaptive immune response;Address;Affect;Afferent Neurons;American;Bacterial Infections;Blood;Bone Marrow;Cations;CCL19 gene;CD4 Positive T Lymphocytes;Cell Adhesion Molecules;cell motility;cell type;Cells;chemokine;Chemotaxis;Chimera organism;Citrobacter rodentium;Colon;Communication;Data;Dendritic Cells;Development;Diphtheria Toxin;Dissection;Endothelial Cells;Endothelium;Enteral;enteric infection;enteric pathogen;Enterocytes;enteropathogenic Escherichia coli;Epithelial Cells;Escherichia coli EHEC;Escherichia coli Infections;experimental study;Foundations;Gastrointestinal tract structure;Goals;health determinants;Hospitalization;Host Defense;host-microbe interactions;Human;Immune;immune function;Immune response;Immunity;Immunologics;In Vitro;in vivo;Induced Neurons;Infection;Infectious Skin Diseases;Inflammation;Injury;Innate Immune Response;innovation;interleukin-22;intestinal epithelium;Intestinal Mucosa;Intestines;Knowledge;Lamina Propria;Lung;Lung infections;Lymphatic Endothelial Cells;Lymphoid Cell;Mechanics;Mediating;member;migration;Modeling;Monitor;Morbidity - disease rate;mortality;Mucosal Immune Responses;Mucosal Immunity;Mucous Membrane;Mus;nerve supply;Neurogenic Inflammation;Neuroimmune;Neurokinin A;Neurons;neurotransmitter release;Neurotransmitters;Nociception;Nociceptors;novel;Outcome;pathogen;pathogenic bacteria;Pathogenicity Island;Peptides;Permeability;Physiological;prevent;Process;Production;protein expression;receptor;recruit;response;Role;Sensory;Skin;Source;Stimulus;Substance P;T-Lymphocyte;therapeutic target;Tissues;TRPV1 gene;Type III Secretion System Pathway;Vasodilation

PROJECT_TITLE: Coordination of mucosal immune response to enteric bacterial pathogens by nociceptive innervation

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


NIH_SPENDING_CATS: Autoimmune Disease;Genetics;Infectious Diseases;Pediatric;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: SEATTLE

ORG_STATE: WA

PHR: Project Narrative The proposed research is highly relevant to the NIH mission and public health because it will help define why Children with Primary Immunodeficiency Disease due to mutations in the NCKAP1L gene encoding Hem-1 fail to respond to immunizations and exhibit high mortality associated with bacterial and viral infections.

PI_NAMEs: IRITANI, BRIAN M (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Actins;Affect;Antibody Formation;Antibody Response;Antibody-mediated protection;Antigens;Autoantibodies;Autoimmunity;autoreactivity;B-Cell Activation;B-Cell Antigen Receptor;B-Cell Development;B-cell receptor repertoire sequencing;B-Lymphocytes;Bacteremia;Bacterial Infections;Biological Models;Bone Marrow;Cell Physiology;cell type;Cells;Characteristics;chemokine;Child;ChIP-seq;Cleavage Under Targets and Release Using Nuclease;Color;Communities;Complex;congenital immunodeficiency;Cre-LoxP;CRISPR/Cas technology;cytokine;Cytokine Receptors;Development;Diffusion;Disease;Exhibits;Family;Flow Cytometry;fly;Gene Expression;Gene Targeting;Genes;Genetic Heterogeneity;genetic regulatory protein;Genetic Transcription;genome wide association study;Goals;Guanosine Triphosphate Phosphohydrolases;Hematopoietic;Homeostasis;Homing;Homologous Protein;Human;human disease;human model;humanized mouse;Humoral Immunities;humoral immunity deficiency;Image;Immune;Immune Tolerance;Immunity;Immunization;immunodeficiency;Immunoglobulin Class Switching;Immunologic Receptors;Impairment;improved;Individual;Infection;Infectious Skin Diseases;Inflammatory Bowel Diseases;Influenza A virus;innovation;Integrins;Knowledge;Ligation;Link;loss of function;loss of function mutation;Lymphoid;Malignant lymphoid neoplasm;Mediating;member;Microscopy;migration;Mission;Modeling;Molecular;mortality;mouse model;Mus;Mutation;novel therapeutics;pathogen;Patients;Plasma Cells;Pneumococcal Pneumonia;Point Mutation;polymerization;Polymers;Predisposition;premature;Production;Prognosis;Proteins;Public Health;Receptor Signaling;Recurrence;Research;Resolution;respiratory pathogen;Respiratory Tract Infections;response;rho;Role;Signal Transduction;stem cells;Streptococcus pneumoniae;System;T-Cell Receptor;T-Independent Antigens;T-Lymphocyte;Technology;Testing;Time;Toll-like receptors;transcriptome;transcriptome sequencing;translational impact;two-photon;United States National Institutes of Health;Untranslated RNA;vaccination strategy;Variant;Virus Diseases

PROJECT_TITLE: WAVE Regulatory Complex in Primary Immunodeficiency Disease and autoimmunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-N(52)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Mental Health;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Environmental cues can reinforce actions and evoke strong, dynamic motivational states during drug seeking and craving to prompt relapse, which poses a significant public health problem in humans with substance use disorders. This proposal will use cutting-edge in vivo and ex vivo techniques to record neural signals and manipulate neuronal activity within the basolateral amygdala, a brain region critical for encoding environmental context information. Understanding how the dopaminergic signaling within and the glutamatergic projections from the basolateral amygdala are engaged during addiction-like behaviors will provide novel insight into mechanisms underlying affective diseases.

PI_NAMEs: BRICKNER, MEGAN A (contact)

PROGRAM_OFFICER_NAME: BABECKI, BETH

PROJECT_TERMS: addiction;Affective;Amygdaloid structure;Anxiety;Association Learning;Behavior;Biosensor;brain circuitry;Brain region;Cocaine;cocaine relapse;cocaine seeking;cocaine self-administration;cocaine use;Color;Communication;craving;Cues;Data;Disease;Dopamine;Dopamine D1 Receptor;drug seeking behavior;Drug usage;Electrophysiology (science);Emotional;extracellular;Fiber;Fright;Glutamates;Human;in vivo;insight;Intake;Learning;Link;Measures;Mental Depression;Mental disorders;Methodology;Methods;Microdialysis;Motivation;Neurons;neurotransmission;novel;Nucleus Accumbens;optogenetics;Outcome;Pathway interactions;Pattern;Pharmaceutical Preparations;pharmacologic;Photometry;Play;Post-Traumatic Stress Disorders;Preparation;Process;Public Health;Rattus;Receptor Activation;Recording of previous events;redshift;Relapse;response;Rewards;Role;Self Administration;Sensory;sensory gating;sensory stimulus;Signal Transduction;Slice;stem;Stimulus;Substance Use Disorder;Synapses;System;Techniques;Testing;tool;transmission process;Ventral Tegmental Area;Visualization

PROJECT_TITLE: Characterizing BLA dopaminergic and glutamatergic mechanisms of dynamic drug seeking

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Digestive Diseases - (Peptic Ulcer);Genetics;Infectious Diseases;Rare Diseases;Stomach Cancer

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE: Helicobacter pylori is a gastric pathogen that colonizes the gastric mucosa of more than half of the global population and is a major risk factor for several gastric pathologies including peptic-ulcer disease and gastric adenocarcinoma. The goal of this project is to determine how reactive oxygen species, a hallmark of H. pylori infection, oxidize host ribosomal proteins and impact their functions. The results of this study will further our knowledge of how H. pylori infection modulates host cellular events and identify signaling axes that could be leveraged for the prevention and treatment of H. pylori-induced gastric pathologies.

PI_NAMEs: RAMANATHAN, RENUKA GANESH (contact)

PROJECT_TERMS: Affect;Bacteria;Bacterial Infections;Binding;Binding Proteins;Biogenesis;biological adaptation to stress;Biological Assay;Cancer cell line;cell growth;Cell Line;Cell Physiology;Cell Proliferation;Cells;Cellular biology;Cellular Stress;cellular targeting;cellular transduction;Chemicals;Chronic;chronic infection;Cysteine;Cytoplasm;Data;Density Gradient Centrifugation;Development;Disease;DNA Damage;driving force;Epithelial Cells;Event;Exhibits;Functional disorder;Gastric Adenocarcinoma;gastric cancer cell;Gastric mucosa;gastric mucosa-associated lymphoid tissue lymphoma;Gastritis;Gastrointestinal Diseases;Generations;Goals;Height;Helicobacter Infections;Helicobacter pylori;Human;Immune response;Immune signaling;Immunofluorescence Microscopy;Infection;Innate Immune Response;insight;Knowledge;Literature;macromolecule;malignant stomach neoplasm;Mammalian Cell;Mass Spectrum Analysis;Measures;Mediating;Metabolism;Microbe;Modification;Molecular;Monitor;mutant;Mutation;neutrophil;Organoids;Outcome;oxidation;Oxidation-Reduction;pathogen;pathogenic bacteria;Pathology;Pathway interactions;Peptic Ulcer;Phenotype;Plasmids;Polyribosomes;polysome profiling;Population;Post-Translational Protein Processing;Prevention;Process;Protein Biosynthesis;Proteins;Proteomics;Puromycin;Quantitative Reverse Transcriptase PCR;Reactive Oxygen Species;Regulation;Resistance;response;Ribosomal Interaction;Ribosomal Proteins;Ribosomal RNA;Ribosomes;Risk Factors;Shapes;Signal Pathway;Signal Transduction;Site;Stomach;Stomach Diseases;Stress;Sucrose;Testing;Tissues;TP53 gene;Translational Repression;Translations;Uridine;Visualization;Western Blotting;Work

PROJECT_TITLE: Redox Regulation of Host Ribosomal Proteins during Helicobacter pylori infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]