NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Atherosclerosis;Biomedical Imaging;Brain Disorders;Cardiovascular;Clinical Research;Dementia;Heart Disease;Neurodegenerative;Neurosciences;Prevention;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative This project aims at elucidating the mechanisms by which cardiac TTR amyloidosis and progressive fibrosis separately contribute to age-related adverse cardiac remodeling in multi-ethnic older adults. We will use state-of-the-art MRI techniques to assess the myocardial extra-cellular volume, as well as left and right ventricular and atrial dysfunction and will use state-of art Tc-99m-PYP techniques to detect the presence and quantify the magnitude of the amyloid burden in the myocardium. The data acquisition methods will be combined with novel statistical methods (machine learning) to achieve the scientific aims of the proposed ancillary study to MESA.

PI_NAMEs: DORBALA, SHARMILA ;LIMA, JOAO A C (contact)

PROGRAM_OFFICER_NAME: JAQUISH, CASHELL E

PROJECT_TERMS: Acceleration;Activities of Daily Living;age related;aging related;Amyloid;Amyloid deposition;Amyloid Fibrils;Amyloidosis;Ancillary Study;Atrial Fibrillation;Autopsy;Biological Markers;Cardiac;cardiac amyloidosis;Cardiac Myocytes;Cardiovascular Diseases;Cicatrix;Cine Magnetic Resonance Imaging;Clinical;clinical diagnosis;Collagen;coronary fibrosis;Data;data acquisition;Dementia;design;Detection;Development;Diffuse;Diphosphates;Disease;Disease Outcome;Early Diagnosis;Electrocardiogram;Exposure to;extracellular;Extracellular Matrix;FDA approved;Fibrosis;frailty;Functional disorder;Heart;Heart Atrium;Heart failure;High Prevalence;Hypertrophy;Image;improved;Individual;Infiltration;interstitial;Knowledge;Left;Libraries;Link;Machine Learning;Magnetic Resonance Imaging;Malignant - descriptor;Maps;Measures;men;Methods;Morbidity - disease rate;mortality;multi-ethnic;Multi-Ethnic Study of Atherosclerosis;Myocardial;Myocardial dysfunction;Myocardium;novel;novel strategies;older adult;older men;Older Population;older women;Participant;Pathogenesis;Pathway interactions;Patients;Phenotype;phenotypic data;Population;Prealbumin;predictive modeling;prevent;Prevention strategy;Proteins;Public Health;Risk Factors;risk stratification;Statistical Methods;Stroke;Technetium;Technetium 99m;Techniques;Ventricular;Woman;β-amyloid burden

PROJECT_TITLE: Interplay of Myocardial Fibrosis and Cardiac TTR Amyloid in Age Related Cardiac Remodeling in MESA-Multi-Ethnic Study of Atherosclerosis

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: AA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences;Substance Misuse

ORG_CITY: RICHMOND

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE This proposal uses alcohol to change nervous system function and test which neuropeptide receptors can act to oppose or promote the action of alcohol. The biological relationship between a behavioral state, a neuronal circuit and the identified neuropeptide receptors will be examined to understand the mechanisms of action.

PI_NAMEs: BETTINGER, JILL C;DAVIES, ANDREW G (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Acute;Affect;Affective;Alcohol consumption;alcohol effect;alcohol response;alcohol sensitivity;alcohol use disorder;Alcohols;Behavior;Behavior Control;Behavioral;behavioral outcome;behavioral phenotyping;Biological;Caenorhabditis elegans;Cells;Chronic;Classification;Complex;Coupled;CRISPR/Cas technology;Data;Development;drug of abuse;Drug usage;Emotional;Enkephalins;Ethanol;experimental study;Exploratory Behavior;gene conservation;gene discovery;gene network;Genes;Genetic;Genetic study;Genetic Techniques;Genetic Variation;Goals;GTP-Binding Proteins;Human;Human Genetics;in vivo;Individual;insight;interest;Investigation;Life;Locomotion;loss of function mutation;Maps;Measures;Mediating;Modeling;Molecular;mutant;Mutation;negative affect;Nematoda;Neprilysin;Nervous System;Nervous System Physiology;neuronal circuitry;Neurons;Neuropeptide Receptor;Neuropeptides;Neurotransmitters;Organism;Orthologous Gene;Outcome;Output;Pattern;Peptide Signal Sequences;Peptides;Pharmaceutical Preparations;Predisposition;Proteins;receptor;Receptor Gene;Regulation;Research;Resistance;resistance mutation;Resources;response;RNA Interference;Role;Serotonin;Signal Transduction;Site;Speed;Substance P;System;Tachykinin;Testing;Time;Variant;Work

PROJECT_TITLE: Neuropeptide receptors, behavioral states and acute ethanol effects

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: DETROIT

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative Aberrant activation of the NLRP3 inflammasome contributes to the pathogenesis of several inflammatory disorders, including Cryopyrin-associated autoinflammatory syndrome, gout, diabetes, and Alzheimer's disease. The goal of this application is to better understand how the NLRP3 inflammasome is activated. Understanding the mechanism of NLRP3 inflammasome activation might guide the development of novel therapeutic strategies for treating inflammatory diseases.

PI_NAMEs: HE, YUAN  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Alzheimer's Disease;Atherosclerosis;ATP phosphohydrolase;autoinflammatory;Binding;CASP1 gene;Crohn's disease;Data;Development;Diabetes Mellitus;Disease;Event;Goals;Gout;human disease;IL18 gene;In Vitro;in vivo;Inflammasome;Inflammatory;Inherited;Innate Immune System;innovation;insight;Interleukin-1 beta;Investigation;Link;Macrophage;Mediating;Molecular;molecular targeted therapies;Natural Immunity;novel;novel therapeutic intervention;Pathogenesis;Pathway interactions;Peptides;Periodicals;Phosphorylation;Phosphotransferases;Potassium;Protein Kinase;Proteins;Regulation;Role;Signal Transduction;Stimulus;Surface;Syndrome;Testing;Therapeutic Intervention

PROJECT_TITLE: Molecular mechanism of NLRP3 inflammasome activation

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ORG_CITY: GAINESVILLE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: P01 Narrative Type 1 diabetes (T1D) is an autoimmune disorder that not only imparts a considerable adverse impact on daily lifestyle but also, over a lifetime, often results in patients that succumb to a series of debilitating disease- associated complications and early mortality. The studies proposed in this P01 are designed to better understand the contributions of genetics to the coordinated immune response that mediates T1D development, through studies of the human pancreas, trafficking through inflamed vasculature, and phenotype/function relationships within the pancreatic draining lymph nodes and peripheral blood samples. We expect knowledge gains from these studies will lead to the identification of improved biomarkers of disease activity, and uncover precision- medicine based targets for therapeutic interventions capable of preventing or reversing T1D autoimmune pathogenesis.

PI_NAMEs: BRUSKO, TODD MICHAEL (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Address;Age;Antigens;Autoantibodies;Autoimmune;Autoimmune Diseases;autoimmune pathogenesis;biobank;Bioinformatics;Biological Markers;Biological Models;Biomedical Research;Biometry;Blood;Blood specimen;causal variant;Cell Differentiation process;cell killing;Cell model;Cell Physiology;Cells;Cellular Stress;Clinical;Clinical Data;Clinical Trials Network;Collection;Communication;Complement;Complex;Consent;Core Facility;Cryopreservation;Cues;Data;data modalities;Data Set;data sharing;Databases;Defect;design;Development;Diabetes Mellitus;Differentiated Gene;Disease;disease model;Disease susceptibility;draining lymph node;Endothelial Cells;Enhancers;Environment;Enzymes;Epigenetic Process;Exons;experience;Florida;Flow Cytometry;gain of function mutation;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Engineering;Genetic Risk;Genome;genome wide association study;Genotype;Goals;Grant;Heterogeneity;Human;human subject;human tissue;Imaging technology;Immune;immune activation;immune function;Immune response;Immune system;Immune System Diseases;Immune Tolerance;Immunologics;Immunophenotyping;improved;In Situ;Individual;induced pluripotent stem cell;Inflammation;Inflammatory;innovation;innovative technologies;insight;Insulin;Insulin-Dependent Diabetes Mellitus;Intervention Trial;islet;Islet Cell;islet cell antibody;Islets of Langerhans;Knowledge;life span;Life Style;Link;lymph nodes;Lymphatic;Lymphoid Tissue;Measurement;Mediating;migration;Modality;Molecular;molecular phenotype;Monitor;mortality;Motility;Natural History;Neighborhoods;novel;novel marker;Organ;Organ Donor;Pancreas;Pathogenesis;Pathologic;Pathway interactions;Patients;Peer Review;Peripheral;peripheral blood;Phenotype;phenotypic data;polygenic risk score;precision medicine;preservation;prevent;Process;programs;promoter;Proteomics;Race;Recording of previous events;Recruitment Activity;Research;Resolution;Resources;Risk;risk variant;Sampling;Series;Serology;sex;Site;Slice;Spleen;Structure of beta Cell of islet;success;System;T-Cell Activation;T-Cell Receptor Genes;T-cell receptor repertoire;T-Lymphocyte;targeted treatment;Technology;Testing;Therapeutic Agents;Therapeutic Intervention;therapeutically effective;Tissue imaging;tissue resource;Tissue Sample;Tissues;trafficking;Transplantation;United States National Institutes of Health;Universities;Variant

PROJECT_TITLE: Immune Function and the Progression to Type 1 Diabetes


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Data Science;Diabetes;Pediatric

PROJECT_TERMS: Address;Administrator;Age;Ambulatory Care Facilities;Autoimmune;Autoimmunity;Belief;Beta Cell;Biological;Biological Markers;Biology;Blood;Blood specimen;Clinical;Collaborations;Collection;Communication;Communication Programs;Communities;Consent;COVID-19 pandemic;Data;data management;Data Protection;data reuse;Data Set;Databases;design;Diabetes Mellitus;Direct Costs;Disease;disorder risk;disparity reduction;Education;Elements;Equilibrium;Evaluation;experience;FAIR principles;Feedback;Florida;Generations;Genetic;Genotype;Goals;Grant;Group Meetings;Human;Human Resources;human subject;Immune;immune function;Immunity;improved;Individual;Infrastructure;Insulin-Dependent Diabetes Mellitus;Interruption;Laboratories;Leadership;Light;meetings;Metabolic;Metadata;Methods;Mission;Modification;National Institute of Allergy and Infectious Disease;operation;Pancreas;Participant;Pathogenicity;Pathology;Patient Recruitments;Patients;peripheral blood;Phenotype;polygenic risk score;Population Heterogeneity;prevent;Principal Investigator;Process;Program Reviews;programs;Progress Reports;public database;Publications;Recording of previous events;recruit;Research;Research Institute;Research Personnel;Resource Allocation;Role;Safety;sample collection;Sampling;Schedule;Secure;Series;sex;Site Visit;social media;Study Subject;success;symposium;synergism;Tissues;trafficking;training project;Trust;United States National Institutes of Health;Universities;Virginia;Visit;web site;webinar;Work;working group;Workplace

PROJECT_TITLE: Administration and Sample Acquisition


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Brain Disorders;Cerebrovascular;Lymphatic Research;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_DEPT: PSYCHIATRY

PHR: Narrative We will use our newly developed MRI (Magnetic resonance imaging) techniques to study brain microvascular and lymphatic system abnormalities in LRRK2 (Leucine Rich Repeat Kinase 2) mouse models of Parkinson’s disease. We will assess whether those abnormalities can serve as potential indicators for PD pathogenic processes and treatment evaluation. These studies will provide a novel understanding of the neuropathological changes underlying PD pathogenesis, which may facilitate the development of biomarkers for diagnostics and PD intervention.

PI_NAMEs: HUA, JUN ;SMITH, WANLI W (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Animal Model;Animals;Arteries;arteriole;behavior measurement;behavior test;Behavioral;biomarker development;Blood - brain barrier anatomy;Blood capillaries;Blood flow;Blood Vessels;Brain;Brain Pathology;Brain region;brain tissue;Cells;cerebral blood volume;cerebrovascular;Cerebrovascular system;Cerebrum;Clinical;Contrast Media;curative treatments;Development;Diagnostic;disease prognosis;Disease Progression;dopaminergic neuron;driving force;early detection biomarkers;Evaluation;Genes;Genetic;Goals;GTP Binding;Histologic;Histology;Human;human model;Image;imaging biomarker;Inflammatory;inhibitor;Intervention;Levodopa;Lipopolysaccharides;Liquid substance;Longitudinal Studies;LRRK2 gene;Lymphatic;Lymphatic clearance;lymphatic malformations;Lymphatic System;lymphatic vessel;Magnetic Resonance Imaging;Measures;Metabolic;Methodology;Methods;Modeling;Monitor;motor deficit;mouse LRRK2 protein;mouse model;Movement Disorders;Mus;mutant;Mutation;Neurodegenerative Disorders;neuron loss;Neurons;neuropathology;novel;Nutrient;Oxygen;Parkinson Disease;Pathogenesis;Pathogenicity;Pathologic;Perfusion;Phenotype;Phosphotransferases;Pilot Projects;Play;Predisposition;Process;Psychophysics;quantitative imaging;research clinical testing;Role;Signal Transduction;spatiotemporal;Speed;sporadic Parkinson's Disease;Structural defect;Structure;System;Techniques;Testing;therapeutic evaluation;Time;Toxin;Treatment Efficacy;Vascular blood supply;Vascular System;Venous;Waste Products

PROJECT_TITLE: Advanced MRI studies of cerebrovascular and lymphatic abnormalities in LRRK2 mouse models of Parkinson's disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: Project Narrative Our lab recently identified an antisense oligonucleotide (ASO) that targets glucose metabolism through alternative splicing of pyruvate kinase (PKM) pre-mRNA, which could be used as a therapy to treat advanced- stage hepatocellular carcinoma (HCC). To advance this work, I plan to define the underlying mechanism for how ASO-based PKM splice-switching (APSS) ultimately leads to reduced HCC growth, and will determine the synergy of APSS therapy with current HCC therapies. The knowledge gained from this proposal will improve our understanding of PKM alternative splicing in tumorigenesis, help to identify synergistic therapies that reinforce the effects of our APSS therapy, and provide further justification for the eventual testing of our APSS therapy in clinical trials for advanced HCC.

PI_NAMEs: VOSS, DILLON MATTHEW (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Alternative Splicing;Amino Acid Transporter;Anabolism;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Apoptosis;BAY 54-9085;bevacizumab;Carbon;Carcinoma;CASP3 gene;Cell Line;Clinical Trials;Combined Modality Therapy;Data;Dependence;design;Disease;effective therapy;Enzyme Inhibition;Enzymes;extracellular;Future;Genes;Glucose;glucose metabolism;Glycolysis;Goals;Growth;improved;In Vitro;in vivo;Incidence;Knowledge;Label;liver cancer model;Malignant Epithelial Cell;Malignant neoplasm of liver;Malignant Neoplasms;Measures;Metabolic;metabolic phenotype;Metabolism;mRNA Precursor;nucleotide metabolism;Pancreatic Ductal Adenocarcinoma;Pathway interactions;Patients;Persons;pharmacologic;Pre-Clinical Model;Primary carcinoma of the liver cells;Production;Progression-Free Survivals;Proliferating;Protein Isoforms;Proteins;Purine Nucleotides;Pyruvate Kinase;Research;Resistance;response;RNA Splicing;Serine;Signs and Symptoms;stable isotope;Stains;synergism;Systemic Therapy;Testing;Therapeutic;Tissues;tumor;tumor growth;tumor metabolism;tumor microenvironment;Tumor Promotion;tumorigenesis;United States;Update;Western Blotting;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Inducing PKM splice-switching with antisense oligonucleotides as an approach to treat hepatocellular carcinoma


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Data Science;Diabetes;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Pediatric

PI_NAMEs: CONCANNON, PATRICK  (contact)

PROJECT_TERMS: Address;Adherence;Administrator;Artificial Intelligence;Autoantibodies;Bar Codes;biobank;Bioinformatics;bioinformatics tool;Biological Assay;Biological Markers;Biometry;Biotechnology;Blood donor;Blood Glucose;Blood specimen;Caring;Cell Line;Cells;Circulation;Clinical;Clinical Sciences;Communities;Complete Blood Count;Consent;Cryopreservation;Custom;Data;Data Analyses;Data Analytics;Data Science;Data Set;data submission;database of Genotypes and Phenotypes;Databases;Defect;Development;Diabetes Mellitus;diabetes pathogenesis;Digit structure;digital;disorder risk;DNA;Documentation;Electronic Mail;Emergency response;Emergency Situation;Ensure;Enzymes;Equipment;Equipment and supply inventories;Exocrine pancreas;Failure;Florida;Flow Cytometry;Freezing;functional genomics;Funding;Generations;Genes;Genetic;Genetic Risk;genome-wide;Genotype;Glucose;Glycosylated Hemoglobin;Glycosylated hemoglobin A;Goals;Human;Image;immune function;Immunologics;Immunology;Immunology procedure;Immunophenotyping;immunoregulation;In Vitro;Individual;induced pluripotent stem cell;Informatics;Information Systems;Infrastructure;insight;Insulin;Insulin-Dependent Diabetes Mellitus;Intake;Interferons;International;islet cell antibody;Laboratories;Leadership;Lymphoid Tissue;Maintenance;Measurement;Medicine;Metabolic;Metadata;Mononuclear;multiple omics;novel;Organ Donor;Pancreas;Pancreatic enzyme;Pathology;Patients;Performance;peripheral blood;Phenotype;Plasma;polygenic risk score;precision medicine;preservation;Procedures;Process;Productivity;programs;Reference Standards;repaired;Reporter;Research;research clinical testing;Research Personnel;Resolution;Resources;Retrieval;risk variant;sample collection;Sampling;Secure;Sensitivity and Specificity;sensor;Series;Serology;Serum;Services;Single Nucleotide Polymorphism;Software Tools;Specimen;Standardization;supercomputer;synergism;System;T-Lymphocyte;Temperature;Tissue Banks;Tissue Sample;tool;Training;Translational Research;Transplantation;United States National Institutes of Health;Universities;Validation;Visualization

PROJECT_TITLE: Biobank, Biostatistics and Bioinformatics


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Our current understanding of how glycans regulate biological events is limited, marred by the technical challenge of analyzing protein glycoconjugate structure and interactions. Our research seeks to bridge the gap between proteins and glycans by using chemical biology approaches. This program can illuminate the nature and behavior of protein glycoconjugates in living cells in the short term, and it can pave the way towards biomedical interventions to promote health in the long term.

PI_NAMEs: HUANG, MIA L (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Address;Behavior;Binding Proteins;Biological;Biology;Cancer Biology;Cell Adhesion;Cells;Chemicals;Development;drug discovery;Event;genetic approach;Glycoconjugates;Glycoproteins;Growth Factor;Health;Health Promotion;Human;Immunity;insight;Intervention;Left;Molecular;Molecular Biology;Nature;Pathway interactions;Physiology;Polysaccharides;programs;Protein Engineering;Proteins;Proteoglycan;Proteome;Research;Signal Transduction;small molecule;Structure;Techniques

PROJECT_TITLE: Bridging the Glycome and Proteome with Chemical Biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Drug Abuse (NIDA only);Neurosciences;Pediatric;Substance Misuse

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: The FIT'NG conference provides a forum for investigators to disseminate novel methods to support understanding of neural mechanisms disrupted due to prenatal and early childhood traumas, present the most cutting edge science that will shift and shape our understanding of the developing brain, sensitive periods of prevention and intervention, and novel mechanisms integral for healthy brain development.

PI_NAMEs: GRAHAM, ALICE M;HOWELL, BRITTANY ROLLINS;SCHEINOST, DUSTIN ;SPANN, MARISA N (contact);ZOLLEI, LILLA

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Address;Adolescence;Adult;Area;Attention;Award;Biomedical Engineering;Birth;Brain;career;Child;Child Development;Childhood;Clinical;Clinical Sciences;Collaborations;Communities;community building;Community Networks;Complex;Computer software;computerized data processing;Conceptions;Data;data acquisition;data quality;Development;Discipline;Disease;early childhood;Education;Educational workshop;Engineering;Environmental Exposure;Ethnic Origin;Event;Faculty;fetal;Fostering;Funding;Group Meetings;Human;human capital;image processing;Individual;Infant;International;Intervention;Knowledge;Learning Disabilities;Life;meetings;Methodology;Methods;Minority Groups;minority scientist;Motivation;multidisciplinary;neurodevelopment;Neurodevelopmental Disorder;neuroimaging;neuromechanism;Neurosciences;Neurosciences Research;Newborn Infant;next generation;novel;Occupational;Outcome;Pain;Participant;pediatric trauma;Physics;Postdoctoral Fellow;postnatal;prenatal;Prevention;Prize;Process;prospective;psychiatric symptom;Psychiatrist;Psychiatry;Psychologist;Psychology;Public Health;Publications;Qualifying;Race;Research;Research Personnel;Resources;response;Science;Scientist;Shapes;Societies;socioeconomics;Students;substance use;symposium;Technical Expertise;Technology;Toddler;tool;Training;Underrepresented Minority;United States;United States National Institutes of Health;waiver;Work

PROJECT_TITLE: Fetal, Infant, Toddler Neuroimaging Group (FIT'NG): Uniting Clinical, Computational, Engineering, and Neuroscience to advance discoveries for the young child.

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Biobehavioral and Behavioral Sciences Study Section[CHHD-H]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biodefense and Related Countermeasures;Cancer;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Emerging Infectious Diseases;HIV/AIDS;Health Services;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Rare Diseases;Substance Misuse;Tuberculosis

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative Sub-Saharan Africa bears the greatest burden of HIV disease globally, and the Central African region is particularly challenged. Research to define the most effective service delivery strategies in these settings is key to decreasing HIV and comorbidities of aging as causes of illness and death. Our research is critical to guide policy makers and program implementers on service delivery mechanisms to provide most efficient use of programmatic resources and the optimal gain to the public's health.

PI_NAMEs: ANASTOS, KATHRYN M. (contact);NASH, DENIS ;YOTEBIENG, MARCEL

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adolescent and Young Adult;Adult;Africa South of the Sahara;African;Age;Aging;AIDS prevention;Alcohols;antiretroviral therapy;Area;Automobile Driving;Biological;Burundi;Cameroon;Cardiovascular Diseases;care outcomes;career;Caring;Central Africa;Cessation of life;Child;Childhood;Climate;Clinic;Clinical;clinical epidemiology;clinical investigation;clinical outcome assessment;Clinical Research;cohort;Collaborations;Collection;comorbidity;Congo;Consensus;Continuity of Patient Care;Country;Data;Data Collection;Databases;Democratic Republic of the Congo;design;Development;Diagnosis;Disease;disorder risk;Enrollment;Epidemiology;epidemiology study;follow-up;Fostering;Funding;Health;HIV;HIV-infected adolescents;Hypertension;Impairment;implementation research;implementation science;implementation strategy;improved;Incidence;Infant;innovation;International;Investigation;Kidney Diseases;Knowledge;Lead;Leadership;Link;Longitudinal cohort;Maternal and Child Health;Mental Health;Mentors;Mentorship;Methods;Mission;Modeling;Monitor;Morbidity - disease rate;mortality;Mothers;next generation;older adult;Outcome;Pathway interactions;pediatric human immunodeficiency virus;Persons;pharmacovigilance;Policies;Policy Maker;Positioning Attribute;pre-exposure prophylaxis;Pregnant Women;prevent;Productivity;programs;psychosocial outcome;Public Health;Publications;pulmonary function;Recurrence;Research;Research Personnel;Research Priority;Resources;Risk;Rwanda;Sentinel;service delivery;service utilization;Services;Site;social stigma;substance use;success;transmission process;Treatment outcome;treatment program;Tuberculosis;tuberculosis treatment;Viral;Work

PROJECT_TITLE: Central Africa International Epidemiology databases to Evaluate AIDS


PI_NAMEs: ATKINSON, MARK A. (contact)

PROJECT_TERMS: Acinar Cell;Address;Affect;Amylases;Antibodies;antigen-specific T cells;Area;Arginine;Autoantibodies;Autoimmune Diseases;autoreactive T cell;Beta Cell;Biological Assay;Blood;Blood Vessels;Carbachol;Cell Fraction;Cell Physiology;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cellular Stress;Collaborations;Cytometry;Data;Defect;Detection;Deterioration;Diabetes Mellitus;diabetes pathogenesis;diabetogenic;Disease;disease natural history;disorder risk;Dissociation;Endocrine;Enzymes;Event;Exocrine pancreas;Extravasation;Failure;Flow Cytometry;Frequencies;Functional disorder;Funding;Gene Expression;Glucagon;Glucose;Hormones;Human;Image;Immune;immune cell infiltrate;immune function;Immune mediated destruction;Immunologic Receptors;Immunophenotyping;Immunotherapeutic agent;Immunotherapy;improved;In Situ;Incubated;Individual;Inflammation;innovation;insight;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;insulitis;Interferons;Intervention;islet;Islet Cell;islet cell antibody;Islets of Langerhans;Knowledge;Lesion;Link;Lipase;live cell imaging;Lobular;lymph nodes;Lymphatic;Maps;Metadata;Molecular;multiple omics;novel;Oligonucleotides;Organ;Organ Donor;Pancreas;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway Analysis;Pathway interactions;Peripheral;Persons;Phenotype;Positioning Attribute;prevent;Production;programs;Proinsulin;Proteomics;PTPRC gene;Reporting;Research Personnel;Residencies;Resolution;response;Role;Sampling;Series;Signal Transduction;single-cell RNA sequencing;Slice;Stains;Stimulus;Surface;synergism;T cell infiltration;T cell receptor repertoire sequencing;T-Cell Receptor;T-Lymphocyte;Testing;therapeutic development;therapeutic target;Time;Tissue imaging;Tissues;tool;trafficking;transcriptomics;Trypsin;Variant

PROJECT_TITLE: Project 1


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Clinical Research;Digestive Diseases;Genetics;Hematology;Liver Disease;Lung;Orphan Drug;Pulmonary Fibrosis;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Defects in telomere maintenance cause a wide spectrum of diseases, including bone marrow failure, cardiovascular disease, pulmonary fibrosis, and cirrhosis, for which effective medical therapies are urgently needed. From genetic studies, we recently discovered that PAPD5, a factor that regulates non-coding RNA pathways, plays a novel and critical role in human telomere biology. This proposal aims to study the mechanisms of action of PAPD5 and new PAPD5 inhibitors, in order to develop new therapies for genetic blood, cardiovascular, lung and liver disorders, and possibly a broad range of aging-related degenerative diseases.

PI_NAMEs: AGARWAL, SUNEET  (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: aging related;Aplastic Anemia;Biochemical;Biogenesis;Biology;Bone marrow failure;Cardiovascular Diseases;Cells;Cirrhosis;Complex;curative treatments;Defect;Degenerative Disorder;Development;Disease;DNA Sequence Alteration;Dyskeratosis Congenita;efficacy evaluation;exhaustion;Exonuclease;Failure;Functional disorder;genetic approach;Genetic Diseases;Genetic study;Goals;Hand;Health;Hematological Disease;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Hematopoietic System;Human;human disease;human model;human stem cells;humanized mouse;Impairment;in vivo;inhibitor;inhibitor therapy;innovation;Knowledge;Length;leukemia;Liver diseases;Liver Fibrosis;Logic;Longevity;Lung Diseases;Medical;Moon;Mus;Mutation;novel;novel strategies;novel therapeutics;Outcome;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Play;Polymerase;Pulmonary Fibrosis;Regulation;Research;Ribonucleoproteins;RNA;Role;self-renewal;small molecule;small molecule inhibitor;Specificity;stem cell function;stem cells;Structure;Systemic Therapy;Techniques;Telomerase;Telomerase RNA Component;telomere;Telomere Maintenance;Testing;Therapeutic;therapeutic development;therapeutically effective;therapy development;tool;Toxic effect;transcriptome;Treatment Efficacy;Untranslated RNA;Work;Xenograft Model

PROJECT_TITLE: Regulation and manipulation of the telomerase RNA component in hematopoiesis

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: Project Narrative/Relevance to Public Health The Gene Expression Database for Mouse Development (GXD) allows the scientific community to examine patterns of gene expression, elucidate biologically important molecular networks, and explore the genetic programs that underlie normal development and disregulations of development leading to human birth defects, to cancer and to many other diseases.

PI_NAMEs: RINGWALD, MARTIN  (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Address;Adult;Anatomy;Applications Grants;bioinformatics infrastructure;Biological;cell type;Cells;central database;Collaborations;Communities;Complex;complex data;Computer Analysis;Congenital Abnormality;Data;data curation;Data Set;Databases;Development;Disease;Documentation;editorial;Electronics;Ensure;experimental study;Feedback;Future;Gene Expression;gene expression database;Gene Expression Profile;gene function;Genetic;genetic information;Goals;Health;Human;Human Development;Human Genetics;Image;Immunohistochemistry;improved;In Situ;In Situ Hybridization;Informatics;informatics infrastructure;infrastructure development;Knock-in;Knowledge;Laboratories;Literature;Maintenance;Malignant Neoplasms;Medical;Metadata;model organism;Modernization;Molecular;Molecular Analysis;mouse development;mouse genome;Mouse Strains;Mus;Mutant Strains Mice;Northern Blotting;online tutorial;Ontology;Organism;Other Genetics;outreach;Pathway interactions;Pattern;Phenotype;Positioning Attribute;Process;programs;Proteins;Public Health;Publications;Reporter;Research;Research Personnel;Resource Informatics;Resources;Reverse Transcriptase Polymerase Chain Reaction;RNA;single-cell RNA sequencing;Software Engineering;software infrastructure;sound;Tissues;tool;Training;transcriptome sequencing;Triage;Western Blotting;Work


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Project Narrative  The pool of individuals that are susceptible to lethal systemic infections caused by the human fungal pathogen Candida albicans is increasing due to new medical treatments and an aging population. Improved therapeutic approaches are needed to due to the limitations of current antifungal drugs and the emergence of drug resistance. The proposed studies are expected to identify the mechanisms by which the C. albicans plasma membrane protects against stressful conditions in the host, which can then be targeted in new antifungal strategies.

PI_NAMEs: KONOPKA, JAMES B (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Address;aging population;Amphotericin;anti-fungal agents;anti-microbial peptide;Antioxidants;Architecture;Azoles;Candida albicans;catalase;cell injury;Cell membrane;Cell Wall;Cells;Cellular biology;Chemicals;Copper;Data;design;Development;Drug resistance;Effectiveness;Environment;extracellular;Flavodoxin;fungus;Future;Genetic;Glutathione;Goals;Hospitals;Human;Hydrogen Peroxide;Hydrophobicity;Hypochlorous Acid;improved;Individual;Infection;Knowledge;Link;Lipid Peroxidation;Lipid Peroxides;Lipids;Mediating;Medical;Membrane;Membrane Lipids;Morphogenesis;neutrophil;novel;novel therapeutic intervention;novel therapeutics;Nutrient;Organ;Oxidants;oxidation;Pathogenesis;pathogenic fungus;Pathogenicity;Pathway interactions;Permeability;Peroxidases;Peroxides;Phagosomes;Phosphatidylserines;Play;Polyunsaturated Fatty Acids;Predisposition;Process;protective pathway;Proteins;Reaction;Resistance;resistant strain;Respiratory Burst;Role;Saccharomyces cerevisiae;Sepsis;SERPINA4 gene;Stress;synergism;Systemic infection;Testing;Therapeutic;therapy outcome;TXN gene;uptake;Virulence;Virulence Factors

PROJECT_TITLE: Plasma membrane promotes stress resistance and virulence of Candida albicans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-H(02)]


NIH_SPENDING_CATS: Biotechnology;Genetics

PROJECT_TERMS: Cellular biology;Computer software;Data;Databases;Developmental Biology;gene expression database;Genomics;Goals;In Situ;Joints;Leadership;meetings;mouse development;Outcome;Program Development;Qualifying;Research Personnel;Seasons;Staff Development;transcriptome sequencing;transcriptomics;Work

PROJECT_TITLE: Admin Core


PROJECT_TERMS: Anatomy;Atlases;Biological Assay;Biological Process;cell type;Cells;Collaborations;comparative;Controlled Vocabulary;Data;data integration;Data Set;data submission;Development;Developmental Anatomy;Disease;editorial;electronic data;Ensure;experimental study;Fostering;gene expression database;Immunohistochemistry;In Situ;In Situ Hybridization;indexing;insight;interest;Knock-in;Laboratories;Literature;Mission;Molecular;mouse development;Mus;Northern Blotting;Ontology;Pathway interactions;Pattern;Phenotype;phenotypic data;Process;Quality Control;Reporter;Research Personnel;Reverse Transcriptase Polymerase Chain Reaction;RNA;Sampling;single-cell RNA sequencing;tool;transcriptome sequencing;Western Blotting;whole genome

PROJECT_TITLE: Curation Core


NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Genetics;Human Genome;Pediatric;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: MATHEWS, CLAYTON E (contact)

PROJECT_TERMS: Adaptor Signaling Protein;African American;African ancestry;Alleles;Amino Acids;Antigen-Presenting Cells;Antigens;Autoantibodies;Autoimmune;Autoimmune Diseases;autoimmune pathogenesis;Autoimmunity;autoreactive T cell;B-Lymphocytes;Beta Cell;Binding;Biological;Biological Models;Black race;Candidate Disease Gene;Cardiovascular Diseases;Catalogs;Caucasians;causal variant;CD8B1 gene;Cell Communication;Cell Physiology;cell type;Cells;Characteristics;Code;cohort;Collaborations;Complex;Consent Forms;CRISPR/Cas technology;cytokine;Data;Dendritic Cells;diabetes pathogenesis;diabetes risk;Disease;disease phenotype;Disease Progression;disease-in-a-dish;efficacious intervention;Elements;endocrine pancreas development;Endothelial Cells;Endothelium;Environmental Risk Factor;Event;Exons;experimental study;Family;Future;Gene Modified;Genes;Genetic Epistasis;genetic variant;Genome;genome wide association study;genome-wide analysis;Genotype;Growth Factor;health care disparity;high risk;Homeostasis;Human;Human Genetics;human induced pluripotent stem cells;human tissue;IFNGR1 gene;Immune;immune function;Immune response;Immune Tolerance;In Situ;Individual;induced pluripotent stem cell;Inflammation;Inflammatory;innovation;Insulin-Dependent Diabetes Mellitus;insulitis;interest;Interferon Type II;Interferons;Investigation;islet;islet cell antibody;Knowledge;Link;Lymphocyte;Macrophage;MAP Kinase Gene;meetings;Missense Mutation;Modeling;Molecular;multiplexed imaging;Mutation;novel;Odds Ratio;Outcome;overexpression;Pancreas;Pathogenesis;Pathogenicity;Pathway Analysis;Pathway interactions;PH Domain;Phenotype;PI3K/AKT;PPBP gene;Pre-Clinical Model;prevent;Production;protective allele;Proteins;Receptor Signaling;recruit;Regulation;Reporting;Research;response;Risk;risk prediction;risk variant;Role;Sampling;seroconversion;SH2B gene;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Single Nucleotide Polymorphism;STAT1 protein;Structure of beta Cell of islet;Study Subject;System;T cell response;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;targeted treatment;Testing;therapeutic candidate;therapeutic target;therapy development;Tissues;TNF gene;transmission process;Tumor Necrosis Factor Receptor;Variant;Vascular Endothelial Cell;vascular inflammation

PROJECT_TITLE: Project 2


ORG_CITY: MINEOLA

ORG_NAME: NEW YORK UNIVERSITY D/B/A NYU LONG ISLAND SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Obesity is one of the risk factors for insulin resistance and type 2 diabetes (T2D), an emerging metabolic disease in the US population. The proposed research will lead to many discoveries that will significantly improve the health of US citizens and others suffering from obesity caused T2D by revealing new concepts and ideas that can be used to develop therapies for the prevention and treatment of T2D. Thus, the proposed research is relevant to NIH's mission that pertains to developing new approaches and fundamental knowledge that will help to reduce the burdens of human disability.

PI_NAMEs: MIAO, QING  (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: 5'-AMP-activated protein kinase;Adipocytes;adiponectin;Agonist;Animal Model;Attenuated;Blood Glucose;Cell membrane;Complex;Data;design;Development;Diabetes Mellitus;Diabetes prevention;diabetic;Diabetic mouse;disability;Enzymes;epidemiologic data;Etiology;evidence base;farnesylation;fasting glucose;feeding;Gene Expression Profile;Gluconeogenesis;Glucose;glucose production;Health;Hepatic;hepatic gluconeogenesis;Hepatocyte;High Fat Diet;Hormone secretion;Hormones;Human;Impairment;improved;insight;Insulin;Insulin Resistance;insulin sensitivity;insulin signaling;Knockout Mice;Knowledge;Laboratories;Liver;Mediating;Metabolic Diseases;Mission;Molecular;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;novel therapeutic intervention;novel therapeutics;obese patients;obese person;Obesity;obesity prevention;Overweight;Pathogenesis;Pathway interactions;Patients;Plasma;Play;Population;Prediabetes syndrome;preservation;prevent;Prevention therapy;Protein Secretion;Proteins;receptor;receptor binding;receptor expression;Regulation;Research;resilience;resilience factor;restoration;Risk Factors;Role;Signal Induction;Signal Pathway;Signal Transduction;STK11 gene;System;Testing;therapy development;Thinness;Transcript;translational potential;United States National Institutes of Health

PROJECT_TITLE: Role of NgBR in regulating hepatic gluconeogenesis and insulin resistance

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Biotechnology;Genetics;Networking and Information Technology R&D (NITRD)

PI_NAMEs: BALDARELLI, RICHARD M (contact)

PROJECT_TERMS: Anatomy;Biological;Biological Assay;Categories;Cell Lineage;cell type;Cells;Chickens;comparative;Complex;Consumption;Custom;Data;data integration;Data Set;Development;Developmental Anatomy;differential expression;Disease;embryo culture;Ensure;Equilibrium;experience;experimental study;Expression Profiling;Fostering;gene expression database;Gene Expression Profiling;gene function;gene product;Genes;Genotype;Image;Immunohistochemistry;improved;In Situ Hybridization;in vivo;indexing;Internet;Intuition;Link;Maps;Metadata;mouse development;Mus;mutant;Northern Blotting;novel;Ontology;Pathway interactions;Pattern;Performance;Phenotype;Process;Productivity;Property;protein protein interaction;Rana;Resolution;Resources;Reverse Transcriptase Polymerase Chain Reaction;RNA;Sampling;Semantics;sex;single-cell RNA sequencing;Site;Source;Specimen;System;Systems Biology;technology development;Text;Time;Tissues;tool;transcriptome sequencing;web interface;Western Blotting;XenBase;Zebrafish

PROJECT_TITLE: Tech Development Core


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Hematology

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: PROJECT NARRATIVE - Mechanism of Divalent Metal Transport by Nramp-Family Transporters Transition metal ions like iron and manganese are essential for many chemical activities in all living cells—e.g., oxygen transport and storage and energy conversion in mitochondria—but are also toxic at too high levels. Our long-term goal is to determine how a family of proteins (called the Nramp family) gets these metal ions across cellular membranes, using biochemistry, crystallography, computer simulations and bioinformatics analyses. This knowledge is critical to understanding how all cells and organisms regulate levels of these transition metals and could help design therapies for disorders caused by imbalances in essential and/or toxic metals, like anemia, hemochromatosis and several neurological disorders.

PI_NAMEs: GAUDET, RACHELLE  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Address;Affect;Affinity;Anemia;Bacteria;Bacterial Model;Binding;Binding Proteins;Binding Sites;Biochemical;Biochemistry;Bioinformatics;Biological Assay;Biological Models;Biophysical Process;Biophysics;Blood;Brain;Carrier Proteins;Case Study;Cell membrane;Cells;Cellular Membrane;chemical property;Chemicals;Chemistry;commensal microbes;Computer Simulation;Coupled;Coupling;Crystallization;Crystallography;Data;Deinococcus radiodurans;Disease;Distant;divalent metal;Energy Metabolism;Energy-Generating Resources;Environment;experimental study;Family;Funding;Geometry;Goals;Health;Hemochromatosis;Homeostasis;Homologous Gene;Homologous Protein;Human;Immune System Diseases;Immunity;Ion Transport;Ions;Iron;Knowledge;Life;Liver;Manganese;member;Membrane Potentials;Metal Binding Site;Metals;Mining;Mitochondria;Modeling;Molecular;Molecular Conformation;molecular dynamics;Movement;Mutagenesis;Mutation;Nervous System Disorder;Nramp protein;Nutrient;Organism;oxygen transport;pathogen;Pathway interactions;physical property;Physiological;Physiological Processes;Predisposition;Property;Protein Conformation;Protein Family;protein transport;Proteins;protonation;Protons;Publishing;Research;Resolution;Role;Scaffolding Protein;Sequence Analysis;SLC11A2 gene;stoichiometry;Structure;symporter;synergism;Testing;therapy design;Thermodynamics;toxic metal;Transition Elements;Trees;Variant

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_DEPT: NEUROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Activity-dependent gene expression links neuronal activity to decoding genomic information and thus provides a powerful support for plasticity of neurons and synapses. L-type voltage-gated calcium channels sense variations in membrane potential and use signaling known as voltage-dependent conformational coupling to pass this information on to an enzyme, CaMKII. This project studies how L-type conformational coupling joins forces with glutamate-gated calcium influx through NMDA receptors to promote local accumulation of CaMKII in dendritic spines, thus driving nuclear transcription and synaptic plasticity.

PI_NAMEs: TSIEN, RICHARD W (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Address;Alzheimer's Disease;antagonist;Area;Automobile Driving;Behavioral;Binding;Brain Diseases;Calcium;Calcium Channel;calmodulin-dependent protein kinase II;Cell Nucleus;Chemicals;Chemosensitization;Communication;Coupling;Cyclic AMP-Responsive DNA-Binding Protein;Dendrites;Dendritic Spines;Depressed mood;detector;Development;Diffusion;Diltiazem;Enzymes;Event;Excision;excitatory neuron;experimental study;fascinate;Gene Expression;Genetic Transcription;Genomics;Glutamates;In Situ;in vivo;Individual;Kinetics;L-Type Calcium Channels;Learning;Light;Link;Mediating;Membrane;Membrane Potentials;Memory;meter;Microfilaments;Modeling;Molecular;Molecular Conformation;molecular dynamics;Mutation;N-Methyl-D-Aspartate Receptors;N-terminal;Neuronal Plasticity;Neurons;neuropsychiatric disorder;neurotransmission;Nimodipine;novel;Nuclear;Nuclear Accidents;Optics;Pattern;Phase;Phosphorylation;Play;postsynaptic;Proteins;recruit;residence;response;Role;Series;Signal Induction;Signal Transduction;Site;Skeletal Muscle;Source;spatial memory;Stimulus;Synapses;Synaptic plasticity;Synaptic Transmission;synergism;Testing;Time;transcription factor;Transcriptional Activation;Transcriptional Regulation;transmission process;Trees;Variant;Vertebral column;voltage;Work

PROJECT_TITLE: Calcium Channels, CaMKII and Mechanisms of Excitation-Transcription Coupling

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: RICHARDSON, JOEL E. (contact)

PROJECT_TERMS: Address;Anatomy;Architecture;Atlases;Biological;cell type;Cells;Computer software;Data;data dissemination;data management;Data Set;data warehouse;Development;Developmental Anatomy;Developmental Gene;Disease;Ensure;experimental study;Gene Expression;gene expression database;gene function;Genes;Health;Human Development;improved;indexing;Industry;Informatics;informatics infrastructure;Information Systems;Infrastructure;interoperability;Literature;Machine Learning;Maintenance;Measures;Metadata;method development;Modernization;Molecular;mouse development;Mus;novel;Ontology;parallelization;Pattern;Performance;phenotypic data;Quality Control;relational database;Reporting;Reproducibility;Research Personnel;Resources;Schedule;Secure;single cell technology;single-cell RNA sequencing;sound;Structure;System;Technology;technology development;Testing;tool;Training;transcriptome sequencing;Triage;Update;web interface;web platform;whole genome

PROJECT_TITLE: Computation Core


NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Genetics;Human Genome;Immunotherapy;Pediatric;Precision Medicine;Prevention

PI_NAMEs: BRUSKO, TODD MICHAEL (contact)

PROJECT_TERMS: Address;Adhesions;Age;Alleles;Antigen-Presenting Cells;arm;autoimmune pathogenesis;Autoimmunity;Automobile Driving;autoreactive T cell;autoreactivity;Avidity;Beta Cell;Biological;Biological Assay;Biological Markers;Biological Models;Biometry;CD4 Positive T Lymphocytes;CD8B1 gene;cell killing;Cell model;Cells;Cellular biology;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;checkpoint receptors;Circulation;Clinical;Clone Cells;Code;Collaborations;Complex;Coupled;CRISPR/Cas technology;cytotoxicity;Data;data acquisition;data integration;Defect;Development;diabetes pathogenesis;diabetes risk;Disease;Disease Progression;disorder risk;Donor Selection;draining lymph node;effector T cell;Elements;Event;Flow Cytometry;Gene Delivery;Gene Expression;Genes;Genetic;Genetic Polymorphism;Genetic Risk;genetic variant;Genome engineering;genome wide association study;genome-wide analysis;Genotype;Haplotypes;Health;high risk;Histocompatibility Antigens Class II;HLA Antigens;Human;human imaging;Immune;immune checkpoint;immune function;Immune system;Immunogenetics;Immunophenotyping;immunoregulation;In Situ;In Vitro;Individual;Inflammatory;Infrastructure;insight;Insulin;Insulin-Dependent Diabetes Mellitus;Intake;islet;Knock-out;Knowledge;Laboratories;Lead;Link;lymph nodes;Lymphatic;Major Histocompatibility Complex;Memory;Metadata;Minor;Molecular;Monitor;multiple omics;Natural History;Pancreas;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Peptides;Peripheral;peripheral blood;Phenotype;polygenic risk score;Population;precision medicine;programs;protein complex;receptor;Receptor Activation;Receptor Signaling;Regulation;Regulatory T-Lymphocyte;Resistance;Risk;Risk Factors;risk variant;Sampling;Signal Transduction;Single Nucleotide Polymorphism;single-cell RNA sequencing;Slice;Specificity;Spleen;Standardization;Surface;Surface Antigens;synergism;System;Systems Biology;T cell differentiation;T cell receptor repertoire sequencing;T-Cell Activation;T-Cell Immunologic Specificity;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Thymus Gland;Tissues;TNFRSF10A gene;Vascular Endothelium

PROJECT_TITLE: Project 3


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Acinetobacter baumannii is a major cause of multidrug-resistant hospital-associated infections and a top priority for the research and development of new antibiotics, according to the World Health Organization. We found that A. baumannii utilizes a previously unrecognized stress-signaling pathway, and strains with mutations in this pathway are more sensitive to antibiotic treatment and oxidative stress. In this application, we propose to investigate the stress response of A. baumannii and its relevance for pathogenesis, which will be foundational to future clinical studies.

PI_NAMEs: FELDMAN, MARIO  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acinetobacter;Acinetobacter baumannii;Acinetobacter Infections;Acute;Adherence;Affect;Anabolism;Antibiotic susceptibility;Antibiotic Therapy;antibiotic tolerance;Antibiotics;antimicrobial;Auxins;biological adaptation to stress;Biological Assay;Biological Process;Catabolism;Categories;catheter associated UTI;Cell Physiology;Cells;Centers for Disease Control and Prevention (U.S.);Clinical;Clinical Research;clinically relevant;Collaborations;combat;Cytoplasm;Disease;Environment;Enzymes;Epithelial Cells;Exposure to;Extracellular Matrix Proteins;Foundations;Future;Gene Expression;gene repression;Genes;Genetic;genetic regulatory protein;Genetic Transcription;High Pressure Liquid Chromatography;Hospitals;Hydrogen Peroxide;Hypoxia;Infection;Iron;Lead;Life;Lung infections;Measures;Mediating;Microbial Biofilms;Modeling;Molecular;mouse model;Multi-Drug Resistance;Multidrug-resistant Acinetobacter;Mus;Mutagenesis;mutant;Mutate;Mutation;novel;novel therapeutic intervention;Operon;Osmosis;Oxidative Stress;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Phagocytes;Phenotype;phenylacetic acid;Phenylalanine;Physiological;Pilum;Plants;pressure;prevent;Process;Production;Property;Regulation;Reporter;Repression;research and development;Research Priority;resistance mechanism;response;Role;Second Messenger Systems;Signal Pathway;Signal Transduction;Signaling Molecule;Stress;stress tolerance;stressor;Sulfamethoxazole;System;Testing;Therapeutic;therapy outcome;transcriptomics;Trimethoprim;Urinary tract infection;Virulence;Work;World Health Organization

PROJECT_TITLE: Phenylacetic acid catabolism, a novel stress-response pathway in Acinetobacter baumannii

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


PROJECT_TERMS: Communication;Communication Tools;Communities;Data;database design;Dedications;Development;Documentation;Education and Outreach;Educational workshop;Electronic Mail;Evolution;Facebook;Feedback;Gene Expression;gene expression database;Hour;Human;Instruction;Internet;Maintenance;Medical;mouse development;outreach;Research;Research Personnel;Resources;Social Network;symposium;Telephone;Training;Twitter;Universities;webinar

PROJECT_TITLE: Dissemination Core


NIH_SPENDING_CATS: Cancer;Lung;Lung Cancer

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE. Precision medicines that specifically target proteins that drive cancer growth are leading to improved responses in many advanced-stage cancer patients. This molecular treatment approach requires a firm understanding of the biological mechanism of cancer development and progression. The studies in this grant proposal focus on the characterization of a new mechanism of oncogenic signaling, focusing on the role of biomolecular condensates in ALK-driven lung cancer, with the overall goal of laying a foundation for developing a new suite of molecular treatments in the future that better control this cancer through improved precision medicine strategies.

PI_NAMEs: BIVONA, TREVER G (contact);SHU, XIAOKUN

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Adaptor Signaling Protein;ALK gene;anaplastic lymphoma kinase;Applications Grants;Architecture;Biological;Biology;cancer cell;Cancer Control;Cancer Etiology;Cancer Patient;Cells;Chimeric Proteins;Clinical;clinically relevant;Complement;Complex;Cytoplasmic Granules;Cytoplasmic Protein;Data;design;Development;Drug resistance;Epidermal Growth Factor Receptor;Foundations;Fusion Oncogene Proteins;Future;Gene Rearrangement;Genetic;genetic approach;Goals;Growth;growth factor receptor-bound protein 2;Histologic;improved;innovation;insight;kinase inhibitor;Lung Adenocarcinoma;Malignant neoplasm of lung;Malignant Neoplasms;MAP Kinase Gene;Membrane;Membrane Lipids;Methodology;Molecular;mortality;multidisciplinary;Mutagenesis;mutant;Non-Small-Cell Lung Carcinoma;Oncogenic;Oncoproteins;Outcome;Output;Pathogenicity;Pathway interactions;Patients;Phase;Phenotype;Phosphotransferases;Physical condensation;precision medicine;protein expression;Proteins;Proteomics;Receptor Protein-Tyrosine Kinases;recruit;Recurrence;response;Role;Set protein;Signal Transduction;Testing;Therapeutic;tool;treatment strategy;tumor growth;Variant;Work

PROJECT_TITLE: Dissecting the role and mechanism of EML4-ALK condensates in oncogenic signaling and tumor growth

STUDY_SECTION: BCO

STUDY_SECTION_NAME: Biochemical and Cellular Oncogenesis Study Section[BCO]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Infant Mortality;Lung;Machine Learning and Artificial Intelligence;Neonatal Respiratory Distress;Networking and Information Technology R&D (NITRD);Neurosciences;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Stroke;Unintentional Childhood Injury

PHR: Narrative To expedite therapeutic innovations in neonates with hypoxic ischemic encephalopathy (HIE), there is an urgent but unmet need to establish an accurate and reliable neonatal biomarker to predict outcomes and assess the impact of novel therapies in a more timely manner. Our Boston Children’s Hospital team - offering Neuroradiology and Artificial Intelligence (AI) expertise - is partnering with the Neonatal Research Network (NRN) - offering data, clinical vision, as well as clinical trial and biomarker experience. We aim to leverage clinical and MRI data collected in previous NRN therapeutic trials for HIE to develop an HIE-specific neonatal AI biomarker for 18-22 month outcomes.

PI_NAMEs: COTTEN, CHARLES MICHAEL;GRANT, PATRICIA ELLEN (contact);OU, YANGMING

PROGRAM_OFFICER_NAME: TAYLOR-BURDS, CAROL C

PROJECT_TERMS: Address;Adverse event;adverse outcome;Agreement;Apgar Score;Area;Artificial Intelligence;artificial intelligence algorithm;Biological Markers;Birth Weight;Boston;Brain;Brain Injuries;brain magnetic resonance imaging;Brain Neoplasms;Brain region;Cessation of life;Clinical;clinical biomarkers;Clinical Data;clinical examination;Clinical Trials;Cognitive;cohort;Complex;Computer software;Consumption;Country;Data;Data Element;Data Set;Entropy;experience;Future;General Hospitals;Geometry;Heterogeneity;Hour;Income;Infant Development;injured;Injury;innovation;International;Letters;Location;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Massachusetts;Multicenter Neonatal Research Network;National Institute of Child Health and Human Development;natural hypothermia;Neonatal;neonatal brain;neonatal encephalopathy;neonatal hypoxic-ischemic brain injury;neonatal magnetic resonance imaging;neonate;Newborn Infant;novel therapeutics;Outcome;outcome prediction;Patients;Pattern;Pediatric Hospitals;postnatal;predictive marker;Prognostic Marker;Reader;Receiver Operating Characteristics;Sample Size;Sensitivity and Specificity;sex;Shapes;Signal Transduction;Site;Socioeconomic Status;Specificity;standard care;Stroke;System;Testing;Texture;Therapeutic;Therapeutic Trials;Time;United States National Institutes of Health;Vision

PROJECT_TITLE: Consortium Of MRI Biomarkers In Neonatal Encephalopathy (COMBINE)

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

PHR: Project Narrative Valvular heart disease affects over 2.5% of the US population. While catheter-based valve interventions substantially decrease patient risk in comparison to open surgery, existing catheters and imaging technologies cannot replicate the dexterity and visualization afforded by open surgery. To enable more effective and more complex beating-heart procedures, we propose to develop cardioscopic imaging and robotic catheter technology that can be delivered through the vasculature.

PI_NAMEs: DUPONT, PIERRE E (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: Address;Adoption;Affect;Algorithm Design;alternative treatment;Animal Experiments;aortic valve;Apical;Articular Range of Motion;base;Blood;Blood Vessels;Cardiopulmonary Bypass;Cardioscopes;Catheters;Clinical;Complex;Data;design;Device Designs;Devices;dexterity;Disease;Effectiveness;Excision;experimental study;Femoral vein;Femur;follow-up;Funding;Goals;Health;Heart;Heart failure;Heart Valve Diseases;Heart Ventricle;Hospitalization;Hour;Image;imaging system;Imaging technology;implantation;improved;in vivo;in vivo evaluation;Intervention;Intuition;Joystick;Left ventricular structure;Length;Length of Stay;Manuals;Medical;meetings;Mitral Valve;Mitral Valve Insufficiency;Morphologic artifacts;mortality;mortality risk;Motion;Operative Surgical Procedures;optical imaging;Optics;Outcome;papillary muscle;Patient Care;Patient risk;Patients;Population;Procedures;Process;Reconstructive Surgical Procedures;Recurrence;repaired;Repeat Surgery;Residual state;Risk;Risk Reduction;Robotics;Shapes;Standardization;System;Techniques;Technology;Time;Tissues;Tricuspid valve structure;ultrasound;Visualization

PROJECT_TITLE: Cardioscopically-guided Valve Repair in the Beating Heart

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dental, Oral, and Craniofacial Disease;Prevention;Social Determinants of Health

ORG_CITY: KHON KAEN

ORG_COUNTRY: THAILAND

ORG_FIPS: TH

ORG_NAME: KHON KAEN UNIVERSITY

PHR: Project Narrative Southeast Asia has over 600 million people, most of whom reside in low and middle-income countries that have a high burden of oral diseases which adversely impacts non-communicable diseases (e.g. diabetes and cardiovascular diseases), child development, and quality of life. There is a clear need for local research to identify risk factors and effective oral health management strategies in Southeast Asian countries, but the lack of personnel and access to training in research methods has been a major impediment to research in the region. We will build a sustainable, effective, and efficient clinical research methods training program by establishing a training hub in Thailand and by forming a regional network of oral health researchers who will conduct quality, locally-relevant research that will contribute to better management of this important public health problem for the benefits of the Southeast Asia.

PI_NAMEs: PITIPHAT, WARANUCH  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Affect;Behavioral;Biometry;Chronic;Clinical;Clinical Research;Collaborations;Country;Dentistry;Dentists;Disease;Doctor of Philosophy;doctoral student;Educational Status;Educational workshop;Faculty;Fellowship Program;Fostering;Funding;Geography;Goals;Health;health management;Healthcare;Home;Human Resources;indicated prevention;Individual;Indonesia;Institution;Knowledge;low and middle-income countries;Malaysia;Medicine;Mentors;Mouth Diseases;Oral;Oral health;Personal Satisfaction;Persons;Pharmacy facility;Philippines;programs;Public Health;public health research;Research;Research Methodology;Research Personnel;Research Proposals;Research Training;Risk Factors;School Dentistry;Science;Series;social culture;social structure;southeast Asian;Southeastern Asia;summer institute;Thailand;Training;Training Programs;Universities;Vietnam;Washington;Work

PROJECT_TITLE: Clinical and public health research training in oral health for Southeast Asia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-L(55)R]


NIH_SPENDING_CATS: Antimicrobial Resistance;Genetics;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Project Narrative/Relevance: Streptococcus pneumoniae, the leading cause of pneumonia, sepsis, and meningitis worldwide, is a model for the study of antibiotic-induced autolysis and the emerging threat of multidrug tolerance. The main pneumococcal autolysin LytA drives both autolysis and the newly discovered capsule shedding response. New data suggests regulators of LytA, discovered through analysis of capsule shedding, affect both the capsule shedding response and activation of autolysis by antibiotics. These regulators may form membraneless organelles as a novel mechanism of thwarting the bacterial lytic response to antibiotics leading to treatment failure.

PI_NAMEs: TUOMANEN, ELAINE I (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Affect;Algorithms;Alleles;Amino Acid Sequence;Animal Model;anti-microbial peptide;Antibiotic Resistance;antibiotic tolerance;Antibiotics;Autolysin;Autolysis;Bacteria;Bacterial Physiology;Bacterial Proteins;bactericide;Binding;Biochemical;Biological;biological adaptation to stress;Biological Assay;Brain;capsule;cathelicidin antimicrobial peptide;Cell Nucleolus;Cell Wall;Cessation of life;Cleaved cell;Clinical;clinical phenotype;combat;Communicable Diseases;Compensation;Complex;Cytolysis;Data;Dissection;Doctor of Philosophy;Down-Regulation;Engineering;Enzymes;Eukaryota;Excision;Failure;Family;Genetic;Genome;genome analysis;Goals;Grant;Growth;Host Defense;Immune;Immunocompromised Host;in vivo;Individual;Infection;insight;Laboratories;Lytic;Membrane;Meningitis;Methods;Microscopic;model organism;Modeling;Molecular;multidrug tolerance;Multiprotein Complexes;Mus;mutant;Mutation;novel;Nyssa;Organelles;pathogen;Pathway interactions;Patients;Penicillins;Phase;Phenotype;Physical condensation;Physiological;Pneumonia;pressure;Process;Production;Property;Proteins;Regulation;Relapse;response;Role;Sepsis;skills;South Africa;spatiotemporal;Streptococcus;Streptococcus pneumoniae;Study models;suicidal;Sum;Surface;System;Testing;Time;Tissues;tool;Treatment Failure;Variant

PROJECT_TITLE: Antibiotic tolerance: membraneless organelles and autolysin regulation

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Neonatal outcome disparities by maternal race, ethnicity and place of birth are persistent and have complex roots that include differential maternal experiences of stress. This project seeks to explore the longitudinal trajectory of resilience (or the ability to respond to stress) during pregnancy as well as any resilience differences that might exist by women’s race, ethnicity, nativity and level of acculturation. By preparing the applicant for a career in longitudinal cohort research and examining the impact of resilience on the relationship between stress and neonatal outcome disparities, this proposal will provide critical foundational knowledge for the development of interventions to build resilience and diminish the risk of poor neonatal outcomes among pregnant minority women and their infants.

PI_NAMEs: MONTOYA-WILLIAMS, DIANA C (contact)

PROGRAM_OFFICER_NAME: MITCHELL, MEGAN S

PROJECT_TERMS: Acculturation;Acute;acute stress;allostatic load;Award;Birth;Birth Place;Birth Weight;Breast Feeding;Buffers;Cardiovascular Diseases;Cardiovascular system;career;career development;Caring;Child Traumatic Stress;Chronic;Chronic stress;Clinic;cohort;Complex;Cultural Backgrounds;Data;Death Rate;decrease resilience;Development Plans;development policy;Diabetes Mellitus;Disparity;early pregnancy;Enrollment;Epidemiology;ethnic disparity;ethnic health disparity;Ethnic Minority Women;Ethnic Origin;ethnoracial;Event;Exhibits;experience;First Pregnancy Trimester;Future;Goals;health disparity;Hispanic;hispanic community;Hispanic Women;Immigrant;Immunologic Markers;improved;improved outcome;Infant;Infant Mortality;innovation;Intervention;Knowledge;Length;Link;Literature;Longitudinal cohort;Longitudinal cohort study;Longitudinal Studies;Low Birth Weight Infant;Maternal Mortality;maternal stress;Measures;Mediator;Mentors;Mentorship;Metabolic;Minority Women;Nature;Neonatal;neonatal health;neonatal outcome;Outcome;outcome disparities;Participant;Pathologic;patient population;Pattern;perceived stress;perinatal health;perinatal period;Persons;Physiological;Population;Pregnancy;pregnant;Pregnant Women;Premature Birth;Premature Labor;Prenatal care;promote resilience;Prospective cohort;psychosocial;Psychosocial Stress;Race;racial disparity;racial health disparity;racial minority women;Reporting;Research;Research Personnel;resilience;response;Risk;Role;Scientist;Secondary to;skill acquisition;skills;Socioeconomic Factors;Spanish/English;Stress;stressor;System;Techniques;Testing;therapy development;time use;tool;Training;Trauma;White Women;Woman;Work

PROJECT_TITLE: Maternal Resilience to Stress, Neonatal Outcomes, and Racial/Ethnic Health Disparities

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


NIH_SPENDING_CATS: Neurodegenerative;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Mitochondria are essential for cellular function and maintain their health through dynamic properties including fusion, division and transport on microtubules. Mitochondrial dysfunction is associated with neurodegeneration and mitochondrial fusion is protective against declining function. This proposal seeks to understand the molecular machinery that mediates mitochondrial fusion.

PI_NAMEs: HOPPINS, SUZANNE C (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Address;age-related disease;Aging;Allosteric Regulation;Apoptotic;Ataxia;Automobile Driving;Behavior;Binding;Binding Proteins;Biochemical;Biochemistry;Biological Assay;Biology;Cell Physiology;Cells;Cellular biology;Collection;Compensation;Complement;Complex;Cytoplasmic Protein;Cytosol;Data;Defect;Development;Disease;Dynamin;Event;experimental study;Family;flexibility;Fluorescence Resonance Energy Transfer;Genes;Goals;GTP Binding;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Health;Homology Modeling;Hydrolysis;Impairment;insight;Knowledge;Link;Maps;Mediating;Membrane;Membrane Fusion;Metabolic;Microtubules;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Molecular Conformation;Movement;Muscle;Mutation;Myopathy;Nerve Degeneration;Neurodegenerative Disorders;Neurons;novel;novel strategies;Optic Atrophy;Organelles;Outer Mitochondrial Membrane;paralogous gene;Pathway interactions;Patients;Peripheral Nervous System Diseases;Polymers;Positioning Attribute;pro-apoptotic protein;Production;programs;Property;Protein Dynamics;Proteins;Publishing;reconstitution;Regulation;Research;self assembly;Shapes;Stimulus;Stress;Structure;Techniques;Testing;therapeutic development;tool;Transmembrane Domain;Tubulin;Variant;Work

PROJECT_TITLE: Determining the mechanism of mitochondrial outer membrane fusion

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Gene Therapy;Genetics;Immunotherapy;Infectious Diseases;Orphan Drug;Precision Medicine;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The purpose of this project is to elucidate the landscape of tumor-intrinsic genetic resistance to immunotherapy for human papillomavirus-associated cancers. Knowledge of the mechanisms of tumor resistance is critical to biomarker discovery and the rational design of new immune-based treatments.

PI_NAMEs: HINRICHS, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Animal Model;anti-PD-1;Antigen Presentation;antigen processing;Antigen Targeting;Architecture;bioinformatics pipeline;Biological Specimen Banks;biomarker discovery;cancer biomarkers;cancer infiltrating T cells;Cancer Patient;cancer therapy;candidate identification;Carcinoma;Cell Therapy;chemotherapy;Clinical Research;Clonal Evolution;Common Carcinoma;Conduct Clinical Trials;constitutive expression;Copy Number Polymorphism;Defect;Dimensions;disease model;Disseminated Malignant Neoplasm;engineered T cells;Event;Evolution;Excision;Frequencies;Gene Expression;Gene Mutation;Genes;genetic resistance;Genomics;Goals;guided inquiry;Hematologic Neoplasms;Heterogeneity;Human;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Immune;immune checkpoint blockade;Immune Evasion;Immune response;Immunotherapy;Interferons;Knowledge;Malignant Neoplasms;Maps;Mediating;Modeling;Mutation;Neoplasm Metastasis;next generation;next generation sequencing;Oncoproteins;Pathway interactions;Patients;Phase;Portraits;pre-clinical research;precision medicine;predictive marker;pressure;rational design;Refractory;Refractory Disease;Research;Resistance;Resistance profile;response;Shapes;T cell therapy;T-Cell Receptor;T-Cell Receptor Therapy;T-Lymphocyte;targeted treatment;Therapeutic;therapy resistant;Time;transcriptomics;Treatment outcome;treatment response;treatment strategy;tumor;tumor heterogeneity;Tumor-Infiltrating Lymphocytes;Viral;Work

PROJECT_TITLE: The Landscape of Tumor intrinsic Genetic Resistance to T cell Therapy


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Individuals with food insecurity may have other non-medical, health-related social needs (e.g., transportation barriers, housing instability, and job insecurity) that decrease their ability to attain glucose control and impact other health outcomes. Leveraging existing programs and relationships, we propose to test the combined effects of a food referral program, a diabetes education intervention, and referrals to address other social needs, on hemoglobin A1c levels in a population of racially/ethnically diverse participants with food insecurity and uncontrolled T2D. Innovative solutions are warranted to combat the long-term sequelae of uncontrolled T2D combined with food insecurity that contribute to the two-fold higher all-cause mortality in T2D that disproportionality impacts lower socioeconomic status and racial/ethnic minority populations.

PI_NAMEs: JOSEPH, JOSHUA J (contact);WALKER, DANIEL M

PROGRAM_OFFICER_NAME: ARTIS DICKERSON, SHAVON

PROJECT_TERMS: Academic Medical Centers;Address;Adult;blood glucose regulation;Caring;Clinic;Clinical Research;combat;Communities;community engaged research;Community Health Aides;Community Health Education;community organizations;comparison control;contextual factors;Control Groups;cooking;Cost Analysis;cost effectiveness;cost-effectiveness ratio;Data;design;diabetes control;diabetes education;Diabetes Mellitus;diabetes self-management;Dose;Education;Educational Intervention;Educational Status;Effectiveness;Employment;Equity;ethnic diversity;ethnic minority population;Evaluation;experience;Face;Focus Groups;Food;Food Access;food insecurity;food preparation;food resource;Glucose;glycemic control;Glycosylated hemoglobin A;Group Interviews;Health;health equity;Health system;Healthcare;Healthcare Systems;Hemoglobin;Housing;housing instability;improved;Incidence;incremental cost-effectiveness;Individual;innovation;interest;Intervention;Link;long-term sequelae;low socioeconomic status;Medical center;member;Methods;microcosting;mortality;National Health and Nutrition Examination Survey;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;Occupations;Ohio;Outcome;Participant;Pathway interactions;Patients;Pattern;peer;Persons;Population;Prevalence;process evaluation;programs;Protocols documentation;Provider;racial diversity;racial minority population;racial population;Randomized;Randomized, Controlled Trials;response;Schedule;screening;Secure;social;social stigma;success;Testing;Transportation;Universities;uptake;Wait Time;Work

PROJECT_TITLE: Linking education, produce provision, and community referrals to improve diabetes care (LINK)

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: MAYWOOD

ORG_DEPT: PHYSIOLOGY

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE  Disrupted protein quality control (PQC) mechanisms, the ability of the cell to remove old/misfolded proteins, is intimately involved in heart failure. The sarcomere, the force generating structure in cardiomyocytes, is under constant mechanical stress that sensitizes its proteins to misfolding; however, the PQC mechanisms involved in maintaining the sarcomere are mostly unknown. Leveraging our recent discovery that this process is, in fact, disrupted in human heart failure, and a protein called BAG3 is critical – this proposal will finally begin to resolve the persistent mysteries of sarcomere PQC; in the future, these discoveries may be used to identify new therapeutic targets for heart failure.

PI_NAMEs: KIRK, JONATHAN A (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: Actins;Autophagosome;BAG3 gene;Binding;Biological Assay;Biophysics;Cardiac;Cardiac Myocytes;Cells;Client;Complex;cost;Data;Depressed mood;Disease;Functional disorder;Future;gene therapy;Generations;Grant;Half-Life;Health;Heart;Heart failure;Heat-Shock Proteins 70;Heat-Shock Response;Human;human induced pluripotent stem cells;Impairment;improved;In Vitro;in vivo;Knockout Mice;Knowledge;Lasers;live cell imaging;Lysosomes;Mechanical Stress;Mediating;Mental Depression;Methods;misfolded protein;Modeling;Modification;Molecular Chaperones;Motility;Mus;Muscle Cells;Myocardial Infarction;Myosin ATPase;Nature;Neonatal;new therapeutic target;Pathway interactions;Patients;Phenotype;Process;protein degradation;protein protein interaction;Proteins;proteotoxicity;Publishing;Quality Control;Rattus;recruit;Regulation;Relaxation;response;Role;Sarcomeres;Sedimentation process;Signal Transduction;spatiotemporal;Stimulus;Stress;Structure;System;Therapeutic;Transgenic Mice;Tropomyosin;Ubiquitin;ubiquitin isopeptidase;ubiquitin ligase;Ubiquitination;ultra high resolution;Ventricular;Visualization;Work

PROJECT_TITLE: Cardiac Sarcomere Protein Quality Control in Health and Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-C(02)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Rural Health;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: WINSTON-SALEM

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narrative Opioid misuse is a critical health issue for young adults; comprehensive prevention intervention efforts are needed to address the complex issue of opioid misuse. Engaging young adults in designing prevention programming and policy targeting opioid misuse may strengthen such efforts by making young adults full partners in creating meaningful and responsive prevention policies in their communities as well as by bolstering individual level protective factors such as self-efficacy and social connectedness. The proposed research to design an organization-level youth engagement strategy is expected to advance our understanding of how prevention organizations can incorporate the voices of young adults into prevention efforts as part of critical multi-component efforts to prevent opioid misuse.

PI_NAMEs: BALLARD, PARISSA JAHROMI (contact)

PROGRAM_OFFICER_NAME: NICKS, SHANNON ELIZABETH

PROJECT_TERMS: acceptability and feasibility;Acute;addiction;Address;Adolescent;Affect;Age;Area;Attitude;Award;Characteristics;Communities;community based participatory research;Community based prevention;community building;community organizations;community partners;community setting;Complex;design;Development;Effectiveness;evidence base;feasibility testing;Goals;Health;Health Policy;Health Promotion;Helping to End Addiction Long-term;improved;Individual;innovation;Institution;Interview;K-Series Research Career Programs;Knowledge;Link;Literature;Manuals;Mentors;misuse of prescription only drugs;multidisciplinary;National Institute of Drug Abuse;Occupations;Opiate Addiction;Opioid;opioid misuse;opioid use;opioid use disorder;Outcome;Pathway interactions;Persons;Pilot Projects;Policies;Policy Making;prescription pain reliever;prevent;Prevention;Prevention program;Prevention strategy;Preventive;preventive intervention;Process;programs;protective factors;Psychologist;psychosocial;Public Health;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recovery;Research;Research Personnel;Resources;Risk;Risk Factors;Risk Reduction;Rural Community;rural setting;Schools;Science;Self Efficacy;skills;social;social capital;Social Development;Societies;Strategic Planning;substance use;substance use prevention;System;Testing;therapy development;Time;Training;transition to adulthood;treatment strategy;United States;United States National Institutes of Health;Voice;Work;young adult;Youth

PROJECT_TITLE: Youth Engagement:  An Organization-Level Strategy to Prevent Opioid Misuse among Young Adults

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: T1DES Project Narrative Diabetes distress has been identified as one of the largest contributors to the racial disparity in glycemic control that disproportionately burdens Black patients ages 18-26 years with type 1 diabetes (T1D). Our study will address diabetes distress among Black young adults by tailoring an intervention relevant to their experiences managing T1D. An evidence-based intervention with demonstrated success among Black young adults would be a significant contribution to existing glycemic control interventions for patients with T1D seeking care in endocrinology practices.

PI_NAMEs: DAVIS, TEANIESE LATHAM (contact)

PROGRAM_OFFICER_NAME: THORNTON, PAMELA L

PROJECT_TERMS: Address;Adolescent;Adult;Age;age group;aged;behavior test;behavioral health;black patient;Black race;Cardiovascular Diseases;care seeking;Caring;Case Management;Childhood;Clinical;clinical care;cognitive function;Cognitive Therapy;comparison control;Complex;Conflict (Psychology);cultural competence;culturally appropriate intervention;Data;data warehouse;diabetes distress;diabetes education;diabetes management;Diabetes Mellitus;Disease Management;Disparity;disparity reduction;Distress;effective intervention;emotion regulation;Endocrinology;evidence base;Evidence based intervention;Exhibits;experience;Family;feasibility testing;Feeling;glucose monitor;glycemic control;Glycosylated hemoglobin A;Goals;Health;health care delivery;health care service utilization;Health education;Healthcare;implementation fidelity;improved;improved outcome;Individual;informant;Insulin-Dependent Diabetes Mellitus;Intervention;Interview;Knowledge;Knowledge Management;Measures;Modeling;motivational enhancement therapy;Neuropathy;non-diabetic;Occupations;Outcome;outcome disparities;Parents;Participant;Patients;Persons;Population;prevent;Problem behavior;Problem Solving;Professional counselor;prospective;Race;racial disparity;racial health disparity;Randomized;randomized, clinical trials;Reporting;Research;Retinal Diseases;Self Management;skills;Social Environment;social situation;Stress;Structure;success;Support Groups;Surveys;Testing;Time;United States;virtual;Work;young adult

PROJECT_TITLE: Evaluating the feasibility of Type 1 Diabetes Education and Support (T1DES) intervention to improve diabetes distress among Black young adults

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Lung;Mental Health;Neurodegenerative;Neurosciences;Prevention;Sleep Research

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative The proposed project seeks to determine how obstructive sleep apnea (OSA) increases Alzheimer's disease (AD) risk by examining how intermittent pauses in breathing, sleep fragmentation, and local deficits in memory- relevant brain waves during sleep relate to AD pathology, structural integrity of medial temporal lobe memory circuits, and the acquisition and retention of episodic and procedural memories. The findings that emerge from this research will characterize which clinical features of OSA are mechanisms underlying the observed increase in AD risk, as well as elucidate whether this increased risk is due to facilitation of AD pathological accumulation, increased vulnerability to AD pathologies due to erosion of medial temporal lobe memory circuits, or both. This work will ultimately offer early, circuit-specific, mechanistic targets supporting the development of novel interventions to delay AD onset, slow AD progression, and minimize cognitive decline in older adults with OSA.

PI_NAMEs: MANDER, BRYCE A. (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Acoustic Stimulation;Address;Age;age related;Age-associated memory impairment;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Apnea;Atrophic;Biological Markers;Brain;Breathing;candidate identification;career;Cephalic;certificate program;Clinical;Clinical Research;Clinical Trials;Clinical Trials Design;clinically relevant;Cognitive;Dementia;density;Development;Differential Diagnosis;Disease Progression;Electroencephalography;entorhinal cortex;Epidemiology;epidemiology study;Episodic memory;Functional disorder;Funding;Future;Geriatric Psychiatry;Goals;Hippocampus;Human;Hypoxemia;Impaired cognition;indexing;Intervention;Intervention Studies;Knowledge;Link;Magnetic Resonance Imaging;Magnetism;Measures;medial temporal lobe;Memory;memory consolidation;memory encoding;Memory impairment;Memory Loss;Mentors;Methodology;Methods;Molecular;Monitor;Motor Skills;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging;novel;Obstructive Sleep Apnea;older adult;Onset of illness;Parietal;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Perforant Pathway;pharmacologic;Physiological;Play;Population;positive airway pressure;Positron-Emission Tomography;pre-clinical;Prevalence;Preventive treatment;procedural memory;Process;programs;Research;Research Activity;Research Personnel;Research Proposals;Resolution;Resources;Risk;Risk Reduction;Role;Severities;Sleep;Sleep Apnea Syndromes;Sleep Deprivation;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;sleep spindle;standard of care;Structure;symptomatology;tau Proteins;Training;Treatment Efficacy;ultra high resolution;Work;β-amyloid burden

PROJECT_TITLE: Relationships between local and global mechanisms of sleep apnea, Alzheimer's disease biomarkers, and memory impairment in cognitively asymptomatic older adults

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Public Health Relevance Statement  Human African Trypanosomiasis (HAT) is a vector-borne parasitic disease, and currently, drugs for curing the disease are few and often toxic to humans. The proposed studies in this application will explore the function and regulation of several of the key cell cycle regulatory proteins that are essential for Trypanosoma brucei to survive in its human and insect hosts. These studies may provide novel targets for drug development and chemotherapy.

PI_NAMEs: LI, ZIYIN  (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: African Trypanosomiasis;Anaphase;Aneuploidy;Binding;Biochemical;Biological;Cell Cycle;Cell Cycle Checkpoint;Cell Cycle Proteins;Cell Cycle Regulation;Cell Cycle Stage;Cell Death;Cell division;Cells;chemotherapy;Chromosome Segregation;Complex;Cyclin-Dependent Kinases;Cytokinesis;Disease;DNA Damage;drug development;Ensure;Eukaryota;event cycle;experimental study;Foundations;Funding;G1/S Transition;G2/M Transition;genetic regulatory protein;Genome;genome integrity;Genomics;Human;Insecta;Investigation;Kinetochores;Lead;Maintenance;Mediating;Metaphase;Microtubules;Mitosis;Mitotic;Molecular;Monitor;Names;new therapeutic target;novel;Nuclear Accidents;Organism;Outcome;Outcome Study;Parasites;Parasitic Diseases;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;Play;premature;prevent;Proteins;public health relevance;Publishing;Regulation;Regulatory Pathway;response;Role;S phase;segregation;Series;System;Testing;Therapeutic Intervention;Time;Trypanosoma;Trypanosoma brucei brucei;Trypanosomiasis;vector-borne;Work;Yeasts

PROJECT_TITLE: Regulation of cell cycle transitions by cyclin-dependent kinase in trypanosomes

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Protecting the cellular proteome is crucial for all aspects of life. Changes in the activity of the players and mechanisms involved in maintaining protein homeostasis are linked to the development of many diseases, particularly amyloid-related neurodegenerative disorders. Our work focuses on two recent additions to the protein homeostasis network; inorganic polyphosphate, a player that serves as protein scaffolding factor in stress resistance and amyloidogenesis, and the histone modification H3K4me3, whose stress-related changes represent a novel mechanism to modulate protein homeostasis.

PI_NAMEs: JAKOB, URSULA H. (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Affect;Alzheimer's Disease;Amyloid;amyloid fibril formation;amyloidogenesis;Anhydrides;arm;Bacteria;Biochemical;Biological;Biology;Cells;Cryoelectron Microscopy;Development;Disease;Epigenetic Process;Gene Expression;Global Change;Goals;Heterochromatin;histone modification;Histones;improved;Inherited;inorganic phosphate;Life;Link;Liquid substance;Mobile Genetic Elements;Modification;Molecular Chaperones;Neurodegenerative Disorders;Neurons;novel;Organism;Parkinson Disease;Patients;Peptide Hydrolases;Phase Transition;Physiological;Polymers;Polyphosphates;Polyps;prevent;Process;protein aggregation;protein misfolding;Protein-Folding Disease;Proteins;Proteome;proteostasis;Regulation;Research;Resistance;Role;Scaffolding Protein;Stress;Structure;Testing;Toxic effect;Work

PROJECT_TITLE: Exploring New Players in Proteostasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious, debilitating illness whose molecular basis is not understood, preventing development of simple diagnostic tests and endpoints for evaluating therapies in clinical trials. This Center will bring together a multidisciplinary team with expertise in immunology, muscle biology, gene expression, cell-free RNA, extracellular vesicles, plasma protein characterization, and computational analysis of large data sets. By assessing biospecimens from subjects at baseline and following symptom exacerbation, the team will seek to understand the underlying pathophysiology of ME/CFS and enhance knowledge of the lay public, patients, and health professionals concerning the disease.

PI_NAMEs: GRIMSON, ANDREW W;HANSON, MAUREEN REBECCA (contact)

PROGRAM_OFFICER_NAME: BREEN, JOSEPH J

PROJECT_TERMS: Advocate;Awareness;Biochemical;Biological Markers;Biology;Biopsy Specimen;Blood Platelets;Blood specimen;brain fog;Cardiopulmonary;Caregivers;Cell Communication;Cell Physiology;cell type;Cells;Chromosome Mapping;Chronic Fatigue Syndrome;Circulation;Clinical;Clinical Data;Clinical Research;Clinical Trials;Cognitive;cohort;Collaborations;college;Communities;Complex;Computational Technique;Computer Analysis;Computing Methodologies;Data;Data Coordinating Center;data integration;data management;design;Development;Diagnosis;Diagnostic;Diagnostic tests;disabling disease;Disease;drug development;effective therapy;Endothelial Cells;Endothelium;epigenomics;Exercise;Exercise Physiology;Exercise Test;Exertion;experience;experimental study;extracellular vesicles;Fatigue;Florida;Fostering;Foundations;Functional disorder;Future;Gene Expression;General Population;Genes;genome resource;Genomics;Goals;Headache;Health Professional;Hemostatic function;Immune;Immune signaling;Immune system;Immunology;improved;Injury;innovation;insight;Investigational Therapies;Knowledge;large datasets;Learning;Location;Malaise;Medical;Molecular;Molecular Profiling;Monitor;monocyte;multidisciplinary;Multiomic Data;multiple omics;Muscle;Musculoskeletal Pain;Neurons;novel;novel strategies;Operative Surgical Procedures;orthostatic intolerance;outreach;Pain;Pathway interactions;Patients;Persons;Physicians;Pilot Projects;Plasma;Plasma Proteins;Population;predictive modeling;prevent;programs;Proteins;Psyche structure;Reagent;Recovery;recruit;Regulation;Research;Research Personnel;Research Project Grants;Resolution;Resources;RNA;Sampling;sedentary;Services;Signal Transduction;Skeletal Muscle;Sleep;Sleep disturbances;Special Hospitals;Symptoms;synergism;Technology;Testing;therapeutic development;therapeutic evaluation;Therapeutic Intervention;Time;tissue injury;Tissues;transcriptome;transcriptomics;Universities;Vascular System

PROJECT_TITLE: Cornell ME/CFS Collaborative Research Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-N(50)R]


NIH_SPENDING_CATS: Chronic Fatigue Syndrome (ME/CFS);Clinical Research

PI_NAMEs: HANSON, MAUREEN REBECCA (contact)

PROJECT_TERMS: Administrator;Advisory Committees;Advocate;Award;biobank;Biological Specimen database;Caregivers;Center for Translational Science Activities;Chronic Fatigue Syndrome;Clinic;Clinical Sciences;Collaborations;college;Communication;Communities;Data;Data Coordinating Center;data integration;Disease;Ensure;Evaluation;experience;Faculty;Florida;Funding;General Population;Genomics;Goals;Human Resources;Infrastructure;Institution;Knowledge;Laboratories;meetings;member;neuroimmunologic disease;New York City;Nongovernmental Organizations;Office of Administrative Management;operation;Operative Surgical Procedures;outreach;outreach program;Participant;patient advocacy group;patient population;Patients;Persons;Physicians;Pilot Projects;Process;Recommendation;Reporting;Research;Research Personnel;Research Project Grants;Resources;response;Scientist;Site;Special Hospitals;Surveys;synergism;Technology;Training;United States National Institutes of Health;Universities;web portal;Work

PROJECT_TITLE: Cornell ME/CFS Collaborative Research Center Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-N]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Genetics;Human Genome;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: This project is a collaborative effort between MD Anderson Cancer Center and University of Texas at Dallas. We will use dorsal root ganglion (DRG) removed from pain phenotyped patients during neurological surgery to gain fundamental new insight into mechanisms of chronic pain and enable therapeutic and biomarker discovery with the opportunity for an almost immediate impact on clinical care.

PI_NAMEs: DOUGHERTY, PATRICK M (contact);PRICE, THEODORE J.

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Address;ADORA3 gene;Affect;Agonist;Anatomy;Automobile Driving;Bioinformatics;biomarker discovery;Biophysics;Brain;case control;Cell Proliferation;cell type;Cells;Chest;chronic pain;clinical care;clinical pain;Clinical stratification;Code;cohort;Data;Data Set;Dependence;dermatome;Electrophysiology (science);Epidemic;experimental study;Family;Female;follow-up;G-Protein-Coupled Receptors;Gene Expression Profile;Generations;Genes;Genetic Transcription;Goals;Harvest;Human;human female;IL6ST gene;immune cell infiltrate;Immune System Diseases;Immunohistochemistry;In Situ Hybridization;Infiltration;insight;Interleukin-6;Intervention;jun Oncogene;Literature;male;Maps;member;Modeling;Molecular;neural;Neuroimmune;Neuronal Dysfunction;neuronal excitability;Neuronal Plasticity;Neurons;neurophysiology;Neurosciences;Neurosurgical Procedures;Nociceptors;novel;oncostatin M;Operative Surgical Procedures;Pain;pain model;pain patient;Pain Research;painful neuropathy;patch clamp;Pathway interactions;Patients;pharmacologic;Phenotype;Physiological;pre-clinical;Pre-Clinical Model;Publishing;Purinergic P1 Receptors;receptor;Regulatory Pathway;RNA;Sampling;sex;sex as a biological variable;sexual dimorphism;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Societies;Spinal Ganglia;Technology;Testing;Therapeutic;therapeutic development;Time;Tissues;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;translational model;University of Texas M D Anderson Cancer Center;Untranslated RNA;Up-Regulation;Vertebral column;women patients;Work

PROJECT_TITLE: Anatomic, Physiologic and Transcriptomic Mechanisms of Neuropathic Pain in Human DRG


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Fatigue Syndrome (ME/CFS);Clinical Research;Data Science;Genetics;Human Genome

PI_NAMEs: GRENIER, JENNIFER K (contact)

PROJECT_TERMS: Antibodies;ATAC-seq;Bar Codes;Biological Assay;Biotechnology;Cell Nucleus;Cells;central database;Chromatin;Chronic Fatigue Syndrome;Clinical;Clinical Data;Collaborations;combinatorial;Complex;cost effective;Custom;Data;data access;Data Analyses;Data Discovery;data hub;data integration;data integrity;data mining;Data Set;data visualization;database query;Databases;Disease;Enzymes;epigenomics;Genes;Genomics;improved;indexing;Individual;innovation;metabolomics;Methods;multimodality;Pathway interactions;Patients;Process;Proteomics;Reagent;Reproducibility;Research;Research Project Summaries;Resources;Sampling;Services;single cell technology;single-cell RNA sequencing;Small RNA;Software Tools;statistics;Technology;Transcriptional Regulation;transcriptome sequencing;transcriptomic profiling;transcriptomics;Transposase;usability;Visualization;Visualization software

PROJECT_TITLE: Research Core