ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: PROJECT NARRATIVE Astrocytes are glial cells that interact with neuronal synapses via their distal processes, where they remove glutamate and potassium (K+) from the extracellular space following neuronal activity. Following traumatic brain injury (TBI), this regulation becomes disrupted and is thought to lead to neurological dysfunction. Here I propose to use cutting edge imaging, genetic, and electrophysiological approaches to determine how molecular changes that alter astrocyte function contribute to synaptic dysfunction using a training plan that will ensure my long-term success.

PI_NAMEs: GARCIA, JACQUELINE P (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Action Potentials;Address;Adult;Affect;Amino Acid Transporter;Animals;Area;aspirate;Astrocytes;Award;Binding;Biology;Brain;Brain Injuries;Buffers;career;Cell Communication;cell type;Cells;Central Nervous System;Collaborations;Communities;Complex;controlled cortical impact;Data;Data Set;Distal;Doctor of Philosophy;Educational workshop;Electrophysiology (science);Ensure;Event;Excitatory Amino Acids;experience;experimental study;extracellular;Extracellular Space;Flow Cytometry;Functional disorder;Functional Imaging;Genetic;genetic manipulation;GLAST Protein;Glutamate Receptor;glutamatergic signaling;Glutamates;Goals;Growth;Image;Immunohistochemistry;improved;Injury;innovation;insight;Institution;inward rectifier potassium channel;Ions;Journals;Knock-out;Laboratories;Mediating;member;Membrane Potentials;Mentors;Modeling;Molecular;mortality;Motion;Mus;Nervous System Disorder;neural repair;Neuroglia;Neurologic Dysfunctions;Neurological Models;Neurons;neurotransmission;Neurotransmitters;novel;Pathologic;Pathway interactions;Patient-Focused Outcomes;Patients;Peripheral;Persons;Phase;Physiology;Play;Positioning Attribute;Postdoctoral Fellow;Potassium;Potassium Channel;Process;Publishing;Regulation;Reporting;Research;Research Personnel;Research Project Grants;response;Role;Scientist;Series;Shapes;Signal Transduction;single-cell RNA sequencing;success;symposium;Synapses;Synaptic Transmission;Technical Expertise;Techniques;Testing;Therapeutic Intervention;Time;Training;transcriptome sequencing;Traumatic Brain Injury;uptake;voltage;Western Blotting;Work

PROJECT_TITLE: Investigating Astrocytic Glutamate and Potassium Dynamics in the Healthy and Injured Brain


ADMINISTERING_IC: DC

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Hearing Loss;Neurosciences;Rare Diseases;Usher Syndrome

ORG_CITY: LEXINGTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHYSIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Advancement in our understanding of molecular mechanisms of key molecules in the inner ear is a prerequisite to developing therapeutic strategies for hearing loss. The studies outlined in this proposal explore structural and functional effects of all eleven reported patient mutations in GIPC3 protein that have been identified to date as a cause of non-syndromic autosomal recessive deafness DFNB72. In addition, since GIPC3 is a previously unexplored molecular partner of other “deafness” proteins, our study will provide fundamental knowledge into the pathophysiological mechanisms of other forms of deafness that will help to reduce the burden of human hearing loss.

PI_NAMEs: FROLENKOV, GREGORY I (contact);VANDER KOOI, CRAIG

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Actins;Adopted;Affect;Age;Age Months;Ankle;Apical;Architecture;Auditory;Auditory system;autosome;Belief;Binding;Biochemical;Biochemistry;C-terminal;Cadherin Domain;CDH23 gene;Cell Physiology;cell type;Cells;Cellular Structures;Complex;Consensus;Coupling;Custom;Data;deaf;deafness;Development;Diameter;dimer;Dimerization;DLG4 gene;Endocytosis;Epidermal Growth Factor Receptor Pathway Substrate 8;Family;Family member;Hair;Hair Cells;Hearing;hearing impairment;Height;Human;in vivo;Inherited;Inner Hair Cells;insight;Knowledge;Label;Labyrinth;Link;live cell imaging;Mechanics;mechanotransduction;Mediating;member;Molecular;Motor;mouse model;Mouse Strains;Mus;mutant;Mutation;MYO7A gene;Myosin ATPase;myosin VI;myosin XVA;N-terminal;nanobodies;normal hearing;novel;Outcome Study;Patients;Phenotype;Physiological;Point Mutation;Positioning Attribute;prevent;Prevention;Protein Family;Proteins;receptor;Receptor Activation;receptor binding;Reporting;response;Rest;Role;Shapes;Site;structural biology;Structure;Surface;Synaptic Transmission;Therapeutic;therapy development;Time;trafficking;two-photon;Ubiquitin;uptake;Vesicle;WHRN gene

PROJECT_TITLE: GIPC3, multifunctional myosin adaptor in mammalian auditory hair cells


ADMINISTERING_IC: AI

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Gene Therapy;Genetics;Health Services;Immunotherapy;Infectious Diseases;Prevention;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of relapsed and refractory hematologic malignancies; however, the immunologic impact and risk for infections and mortality following treatment have not been well-characterized. This Career Development Award focuses on applying advanced clinical epidemiology and simulation modeling to understand the immunologic impact of CAR T-cell therapy. Our overall objective is to identify predictive risk factors and cost-effective screening methods to allow for risk stratification, protocols for immunologic monitoring, and initiation of earlier interventions to mitigate the risk for morbidity and mortality and improve quality of life.

PI_NAMEs: BARMETTLER, SARA  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;Adult;Age;Antibodies;B cell therapy;B-Lymphocytes;Bayesian Analysis;Biometry;cancer diagnosis;CAR T cell therapy;career;career development;CD19 gene;Characteristics;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;clinical epidemiology;Clinical Research;clinical risk;clinically significant;cohort;Communicable Diseases;comorbidity;cost;cost effective;cost effectiveness;cost-effectiveness evaluation;Coupled;cytokine release syndrome;Data;Development;Diagnosis;Dose;Early identification;Early Intervention;Education;Environment;Epidemiology;experience;FDA approved;Frequencies;Future;General Hospitals;Goals;Health;Health Care Costs;Healthcare Systems;Hematologic Neoplasms;high risk;Hypersensitivity;hypogammaglobulinemia;Immune;Immune System Diseases;immunodeficiency;Immunoglobulins;Immunologic Monitoring;Immunologics;Immunology;Immunomodulators;Immunophenotyping;improved;improved outcome;Infection;infection risk;instructor;International;Intervention;K-Series Research Career Programs;Knowledge;Leadership;Life;longitudinal analysis;Lymphopenia;Malignant - descriptor;Malignant Neoplasms;Massachusetts;medical schools;Medicine;Mentors;Mentorship;Methods;Modeling;models and simulation;Monitor;Morbidity - disease rate;mortality;Outcome;Outcome Measure;Patient Outcomes Assessments;patient subsets;Patient-Focused Outcomes;Patients;Pediatric cohort;Peripheral;Physicians;Population;Productivity;professor;prospective;Protocols documentation;Quality of life;Questionnaires;receptor;Recommendation;Refractory;Relapse;Replacement Therapy;Research;Research Personnel;Research Proposals;Research Training;responsible research conduct;Retrospective cohort;Risk;Risk Factors;risk mitigation;risk prediction;risk prediction model;risk stratification;rituximab;Scientist;screening;Serum;Severities;sex;skills;success;Surface Antigens;Techniques;therapeutic target;Training;Training Programs;tumor;Tx receptor;Work

PROJECT_TITLE: Modeling Risk for Hypogammaglobulinemia, Infections, and Mortality with Chimeric Antigen Receptor (CAR) T-cell Therapy

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: SURGERY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative We are trying to understand how a single molecule, prestin, can influence the mammal's exquisite sense of hearing by studying its cryo-EM structure. We propose to study the influence of voltage and other manipulations that alter its voltage-dependent state to identify conformations that normally occur duing outer hair cell activity. This will aid in understanding how the OHC enables us to hear so well and in turn how we might combat pathologies of the OHC that afflict millions.

PI_NAMEs: NAVARATNAM, DHASAKUMAR S;SANTOS-SACCHI, JOSEPH R (contact)

PROJECT_TERMS: Affect;Anions;Area;Behavior;Bicarbonates;Cell membrane;Charge;Chlorides;Cholesterol;Cochlea;combat;Computer Simulation;conformational conversion;Contracts;Crosslinker;Cryoelectron Microscopy;Cyclosporine;Cysteine;Detergents;Electric Capacitance;Environment;Family;Fatty Acids;Free Energy;Goals;Hearing;Height;image processing;Lateral;Length;Lipids;loss of function;Mammals;Measurable;Mediating;member;Membrane;Membrane Lipids;Membrane Potentials;Membrane Proteins;Methodology;Methods;Micelles;millisecond;Modeling;Molecular;Molecular Conformation;molecular dynamics;Molecular Motors;Motor;Movement;mutant;Mutation;nanodisk;Outer Hair Cells;Paper;Pathology;Pathway interactions;Physiological;preservation;Process;Property;protein structure;Proteins;rat Pres protein;Resolution;response;Salicylic Acids;Sampling;Seminal;sensor;single molecule;Structure;System;Temperature;Time;Vesicle;voltage;Work

PROJECT_TITLE: Membrane properties of the OHC system


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Pediatric;Social Determinants of Health;Violence Research;Youth Violence

ORG_CITY: EAST LANSING

ORG_DEPT: PSYCHOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Neighborhood disadvantage is a potent predictor of youth risk-taking and aggressive antisocial behaviors (ASB). The proposed project will empirically evaluate methylomic modifications as one pathway through which neighborhood disadvantage leads to youth ASB. We specifically postulate that exposure to the physical (lead, cotinine) and social (harsh parenting, exposure to community violence) `active ingredients' of neighborhood disadvantage alter the development of the methylome, and in doing so, increase youth ASB.

PI_NAMEs: BURT, S. ALEXANDRA  (contact);CLARK, SHAUNNA L

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Adolescence;Adolescent;antisocial behavior;Area;Base Sequence;Behavior;Biological;Biological Assay;Blood;Child Rearing;community violence;Cotinine;Data;Development;Developmental Process;Disadvantaged;Dizygotic Twins;DNA;DNA Methylation;early adolescence;Elements;Environment;Environmental Exposure;Epigenetic Process;epigenome;Etiology;Exposure to;Genetic;Genetic Predisposition to Disease;Genome;Human;indexing;Individual;infancy;Lead;Life;Link;Longitudinal Studies;Mediating;Mediator;Methylation;methylome;methylomics;middle childhood;Modification;Monozygotic twins;neighborhood disadvantage;Neighborhoods;Neonatal;Neurotoxins;Pathway interactions;Peripheral;Phenotype;postnatal development;Poverty;predictive marker;prospective;Public Health;response;Risk;Risk Taking;Saliva;Salivary;Sampling;Site;social;Source;Spottings;Time;Tissues;Toxicant exposure;Twin Multiple Birth;Twin Studies;United States;Variant;violence exposure;Work;Youth

PROJECT_TITLE: The methylomic consequences of neighborhood disadvantage for youth risk-taking behaviors.

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Patient Safety

ORG_CITY: BALTIMORE

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative The research proposed here will investigate the feasibility of using novel applications of computer vision and cooperative control robotics to enforce virtual safety barriers in neurotologic surgery. Our long-term goal is to develop semi-autonomous, robotic methods to improve the safety and efficiency of neurotologic surgery, and open the possibilities for surgical interventions which currently are beyond the abilities of the human hand alone.

PI_NAMEs: CREIGHTON, FRANCIS XAVIER (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: 3-Dimensional;Address;Adoption;Algorithms;Anatomy;Area;Atlases;automated segmentation;Automobile Driving;Automobiles;Biomedical Engineering;Cadaver;career;Cochlea;Communication;Complex;computer science;Computer Vision Systems;Computers;Consumption;deep learning;Development;digital;digital data;digital imaging;Drug Delivery Systems;Dura Mater;Educational process of instructing;Electromagnetics;Engineering;Equilibrium;Ethics;Facial nerve structure;Feedback;Future;Goals;Hand;Head and Neck Surgery;Hearing;Human;Image;image guided;image registration;Image-Guided Surgery;improved;instrument;Intervention;Judgment;K-Series Research Career Programs;Knowledge;Labyrinth;Lateral;learning network;Left;Manuals;medical schools;Mentors;Methods;Microscope;microscopic imaging;millimeter;Modeling;Modernization;Monitor;Motion;Movement;multidisciplinary;neurovascular;novel;Operative Surgical Procedures;Otolaryngology;Outcome;Patients;Positioning Attribute;Postoperative Period;Procedures;Process;professor;Research;Research Personnel;responsible research conduct;Robot;robot control;Robotics;Safety;Scientist;Shapes;Sigmoid colon;simulation;Site;skills;skull base;Speed;stereoscopic;Structure;success;Surface;Surgeon;surgery outcome;Surgical complication;Surgical Instruments;System;Tactile;Techniques;Technology;Temporal bone structure;Testing;three-dimensional modeling;Time;Training;Tremor;Update;virtual;Work;X-Ray Computed Tomography

PROJECT_TITLE: Cooperative Control Robotics and Computer Vision: Development of Semi-Autonomous Temporal Bone and Skull Base Surgery

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: ALBUQUERQUE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECT NARRATIVE Among the gynecological cancers, patients with ovarian cancer have the worst outcomes, indicating the need for new and improved treatments. Our published work has shown that high levels of DNA ligase I, a key DNA replication enzyme, correlate with poor outcomes and resistance to chemotherapy in ovarian cancer, and that specific forms of ovarian cancer are sensitive to a DNA ligase I inhibitor. We expect that the results of this grant will identify DNA ligase I as a valid target for development as a drug that will be used to improve outcomes for patients with ovarian cancer.

PI_NAMEs: TOMKINSON, ALAN E (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Abnormal DNA Repair;Animal Model;Biochemical;Biological;Biological Assay;Biological Markers;cancer cell;Cancer cell line;Cancer Model;cancer therapy;Cell Line;Cell Survival;Cells;Chemicals;Chemoresistance;chemotherapy;Complex;Critical Pathways;Defect;design;Development;Disease;DNA biosynthesis;DNA Damage;DNA ligase I;DNA Ligases;DNA Repair;DNA Repair Inhibition;DNA Repair Pathway;DNA replication fork;DNA Sequence Alteration;DNA strand break;drug development;early phase clinical trial;effective therapy;efficacy evaluation;Enzymes;Excision;Excision Repair;Experimental Models;Frequencies;Future;Genes;Genetic;Genome;genotoxicity;Goals;Grant;Human;human DNA;Hypersensitivity;improved;improved outcome;Incubated;Inherited;inhibitor;insight;intraperitoneal;Knockout Mice;Lesion;Ligase;Link;Maintenance;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Modeling;Molecular;Molecular Medicine;molecular modeling;Mus;Nature;novel;novel therapeutic intervention;novel therapeutics;nuclease;Null Lymphocytes;Okazaki fragments;Organoids;Outcome;Ovarian;overexpression;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Platinum;Platinum Compounds;Play;Poly Adenosine Diphosphate Ribose;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;pre-clinical;Predisposition;Prognosis;Progression-Free Survivals;Property;Proteins;Publishing;Regimen;repaired;Resistance;Resolution;response;Role;screening;Single Strand Break Repair;standard care;Structure;targeted treatment;taxane;Testing;Therapeutic;therapeutic development;Therapeutic Uses;Work;Xenograft Model;XRCC1 gene

PROJECT_TITLE: Targeting DNA Ligase I in Ovarian Cancer

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Clinical Research;Emergency Care;Health Services;Infectious Diseases;Patient Safety;Pediatric

ORG_CITY: ROCHESTER

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE Emergency department clinical decisions vary widely for febrile infants, who are at risk for potentially fatal invasive bacterial infections; some infants may experience harms from under-testing or over-treatment. There is a gap in scientific knowledge regarding how clinicians make decisions for febrile infants and the extent to which key sources contribute to practice variation. Addressing this gap will provide a foundation for addressing NICHD priorities of improving care to febrile infants and promoting health equity.

PI_NAMEs: YAEGER, JEFFREY PAUL (contact)

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: Academy;Accident and Emergency department;acute care;Address;administrative database;Adoption;Affect;Age;Agreement;American;Antibiotics;Atlases;Bacteremia;Bacterial Infections;Beds;Belief;Biological Markers;Blood;Board Certification;career;career development;Caregivers;Caring;Characteristics;Child Health;Child health equity;Childhood;Clinical;clinical decision-making;Clinical Practice Guideline;Code;Complex;Consensus;contextual factors;cost;Data;Data Set;Decision Making;density;Development Plans;Diagnosis;Disease;Educational workshop;Effectiveness;Emergency Medicine;Ensure;Equity;evidence base;experience;Family Practice;febrile infant;Fever;Focal Infection;Foundations;Funding;Geography;Goals;health equity promotion;Health Sciences;Health Service Area;hospital services;Hospitalists;Hospitalization;improved;improved outcome;Individual;Inequity;Infant;Infant Health;infection rate;Intervention;Interview;Intramuscular;Knowledge;knowledge base;Learning;Light;Location;Maps;Medical;Meningitis;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Modeling;multilevel analysis;National Institute of Child Health and Human Development;New York;Outcome;overtreatment;parenteral administration;Parents;Patients;Pattern;pediatric emergency;Pediatrics;Physicians;Population;population based;preference;Public Health;Publications;Quality of Care;Research;Research Personnel;Residual state;Resources;Risk;risk stratification;Science;Secure;Site;skills;Small-Area Analysis;Small-Area Variations;social factors;Source;Spinal Puncture;Testing;Training;Training Programs;Universities;Variant

PROJECT_TITLE: Using Small Area Variation Analysis to Investigate Sources of Practice Variation for Febrile Infants at Risk for Invasive Bacterial Infections

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative  The proposed studies are aimed at developing a fluorescence microscopy method to monitor, on angstrom-and-millisecond scales, three-dimensional conformational changes of proteins, such as ion channels, a class of proteins that enable specific types of ions to flow across cellular membranes to generate vital cellular electricity. The resulting data will in turn allow us to understand the mechanisms of these protein molecules, necessary knowledge for developing therapeutic agents such as antibiotics.

PI_NAMEs: LU, ZHE  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: 3-Dimensional;Acceleration;alpha helix;Antibiotic Resistance;Antibiotics;Bacteria;Behavior;Binding;Cell membrane;Cells;Cellular Membrane;combat;Complex;Cryoelectron Microscopy;Crystallography;Data;Defect;Dependence;Disease;Electricity;Enterobacteriaceae;Equilibrium;Event;experimental study;Fluorescence Microscopy;Fluorescence Polarization;fluorophore;Four-dimensional;Goals;Growth;Individual;Investigation;Ion Channel;Ions;Kinetics;Knowledge;Ligands;light microscopy;Measures;Membrane Proteins;Methods;Microscope;millisecond;Modeling;Molecular Conformation;Monitor;Motion;Nucleotides;pathogenic bacteria;Pathogenicity;Polarization Microscopy;Potassium Channel;Probability;Process;Protein Conformation;Protein Dynamics;protein structure;Proteins;Radial;Regulation;Resolution;Rotation;Science;Seafood;Series;Signal Transduction;Site;Sorting;Space Perception;spatiotemporal;Specific qualifier value;structural biology;Structure;success;System;Techniques;Therapeutic Agents;therapy development;Thinking;Time;Vibrio parahaemolyticus

PROJECT_TITLE: Angstrom-scale structural dynamics of a potassium channel

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: We propose that available BH3 mimetic drugs such as navitoclax (targeting BCL2/BCLXL), and newly emerging BH3 mimetics that target MCL1, can be exploited in prostate cancer (PC) to lower the apoptotic threshold, and in subsets with certain genomic alterations or in combination with appropriate agents can generate marked apoptosis and hence durable responses. Identification of genomic alterations and optimal combination therapies that exploit these drugs and the unique vulnerabilities of PC cells, is the overall objective of this proposal.

PI_NAMEs: BALK, STEVEN P. (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: Acute;Affect;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Androgens;Apoptosis;Apoptotic;Automobile Driving;BAX gene;BCL2 gene;BCL2L1 gene;BCL2L11 gene;Binding;Biological Markers;Blood Platelets;BRCA2 gene;Castrate sensitive prostate cancer;Castration;Cellular Stress;Clinical;Clinical Trials;Combined Modality Therapy;Data;Dependence;DNA Sequence Alteration;efficacy evaluation;Exposure to;FDA approved;Gene Amplification;Gene Deletion;Hematologic Neoplasms;in vivo;inhibitor;Malignant neoplasm of prostate;MCL1 gene;Mediator;Medical Castration;Metastatic Prostate Cancer;mimetics;Mitochondria;Modeling;Pathway interactions;Patients;Pharmaceutical Preparations;preclinical study;pro-apoptotic protein;prostate cancer cell;Protein Family;Proteins;RB1 gene;Recurrence;response;Role;Signal Transduction;Solid Neoplasm;standard care;targeted agent;Thrombocytopenia;Toxic effect;tumor;ubiquitin ligase;VCaP

PROJECT_TITLE: Prostate Cancer Vulnerabilities to BH3 Mimetic Drugs

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Cardiovascular;Eye Disease and Disorders of Vision;Nutrition

ORG_CITY: DALLAS

ORG_DEPT: GENETICS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: The key enzyme in cholesterol synthesis, HMG CoA reductase (HMGCR), is controlled through multiple mechanisms, including regulation of protein degradation. This grant will investigate mechanisms through which UBIAD1, an enzyme that synthesizes a vitamin K form called menaquinone-4 (MK-4), modulates HMGCR degradation and elucidate tissue-specific functions of MK-4. Completion of proposed studies will provide insight into mechanisms for HMGCR degradation, therapies that reduce the incidence of cardiovascular disease and heart attacks, and significance of tissue-specific distribution of MK-4.

PI_NAMEs: BOOTH, SARAH LOUISE;DEBOSE-BOYD, RUSSELL ALFRED (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Acceleration;Acinar Cell;Adult;autosome;Binding;Biology;Blood;Cardiovascular Diseases;Cause of Death;Cells;Cholesterol;cholesterol control;Cholesterol Homeostasis;Clinical;clinical effect;Cornea;Coronary Arteriosclerosis;Cultured Cells;Dimethylallyltranstransferase;Diphosphates;Disease;Dolichol;Drug Prescriptions;Embryo;Endoplasmic Reticulum;Enzymes;Exhibits;Eye diseases;farnesyl pyrophosphate;Feedback;Functional disorder;geranylgeranyl pyrophosphate;Germ Lines;Goals;Golgi Apparatus;Grant;Hepatic;Histologic;Homeostasis;Human;Hydroxymethylglutaryl-CoA reductase;Incidence;inhibitor;Injury;insight;Intestines;isoprenoid;knock-down;Knock-in Mouse;Knock-out;knockout gene;Knockout Mice;LDL Cholesterol Lipoproteins;Liver;Mediating;Membrane;Metabolism;mevalonate;Missense Mutation;Modality;Morphology;Mus;Muscle;mutant;Mutation;Myocardial Infarction;Myopathy;Nuclear Receptors;Outcome;Pancreas;Pathway interactions;Patients;pharmacologic;Phenotype;Phosphoric Monoester Hydrolases;Physiological;Plasma;pregnane X receptor;prevent;Process;protein degradation;Proteins;Reaction;receptor binding;Regulation;Reporting;Resistance;response;Role;Schnyder corneal dystrophy;sensor;Site;Skeletal Muscle;Sterols;targeted treatment;Tissues;Ubiquinone;Ubiquitination;Vitamin K;Vitamin K 2;Xenobiotics

PROJECT_TITLE: Significance of UBIAD1 in Regulation of HMG CoA Reductase Degradation, Mevalonate Metabolism, and Menaquinone-4 Synthesis

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Clinical Research;Congenital Structural Anomalies;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hearing Loss;Human Genome;Neurosciences;Pediatric;Precision Medicine;Racial and Ethnic Minority Health Research

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Our proposal seeks to unravel the molecular mechanisms underlying severe non-syndromic cochleovestibular and cochleovestibular nerve malformations. We will employ a comprehensive genomic analysis to identify the key molecular events implicated in the development of these malformations. Our proposed research promises to yield novel insights into inner ear development and can pave the way for the development of better molecular diagnostic tools and future personalized treatment.

PI_NAMEs: SCHRAUWEN, ISABELLE VEERLE SUZANNE (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: Affect;African;Anatomy;autosome;Belgium;Bilateral;bone imaging;Candidate Disease Gene;causal variant;Cells;Child;Child Development;Cities;Clinical;Cochlea;cohort;Collaborations;Collection;Complex;congenital hearing loss;cost effective;Counseling;Country;craniofacial;dark matter;Data;Data Set;Databases;de novo mutation;Defect;demographics;Developed Countries;Development;Diagnosis;Diagnostic;diagnostic screening;diagnostic tool;Disabling;Disease;DNA;Ear;ethnic diversity;ethnic health disparity;Ethnic Origin;Ethnic Population;Etiology;Event;exome;exome sequencing;experimental study;Family;Future;Gene Expression;Genes;Genetic;genetic architecture;Genetic Predisposition to Disease;genetic variant;genome sequencing;genomic data;genomic variation;Genomics;health disparity;hearing impairment;Height;Hispanic;Hispanic Populations;Hospitals;Human;Image;Imaging Techniques;improved;In Situ Hybridization;Individual;inner ear development;innovation;insight;Intervention;Knowledge;Labyrinth;Magnetic Resonance Imaging;malformation;Methods;Mexico;Modeling;Molecular;Molecular Diagnosis;Molecular Diagnostic Testing;molecular diagnostics;Nerve;Neural Crest;New York City;Newborn Infant;Not Hispanic or Latino;novel;novel therapeutic intervention;Otolaryngologist;outcome prediction;Parents;participant enrollment;Pathogenicity;Patients;personalized medicine;Phenotype;phenotypic data;Population;Population Heterogeneity;preference;proband;Productivity;Race;racial diversity;racial health disparity;racial population;recruit;Repetitive Sequence;repository;Research;Resolution;Resources;RNA analysis;screening;Sensorineural Hearing Loss;Sensory;Site;sound;South Asian;Temporal bone structure;Therapeutic;therapeutic development;Therapeutic Intervention;transcriptome sequencing;United States;Variant;Washington;Work;X-Ray Computed Tomography

PROJECT_TITLE: Unraveling the genetic architecture of cochleovestibular malformations

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Hypertension;Patient Safety;Prevention;Primary Health Care

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Narrative The proposed project seeks to improve adherence to medications that treat high blood pressure. We will refine an innovative intervention to address medication nonadherence through use of pharmacy data and team- based care in primary care clinics. We will then study if the intervention improves medication adherence and blood pressure control.

PI_NAMEs: BLECKER, SAUL B. (contact);MANN, DEVIN M;SCHOENTHALER, ANTOINETTE M

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Address;Adherence;Adoption;Anti-Hypertensive Agents;Assessment tool;Behavior;behavior change;Blood Pressure;blood pressure control;Cardiovascular system;Clinic;Clinical;clinical decision support;clinical practice;Cluster randomized trial;Communication;comparison control;cost effectiveness;Data;Effectiveness;effectiveness evaluation;Electronic Health Record;Electronics;Health;Health system;Hospitals;Hybrids;Hypertension;implementation evaluation;implementation intervention;implementation outcomes;implementation/effectiveness;improved;innovation;Intervention;intervention refinement;Intervention Studies;Interview;Link;Measures;Medical;medication compliance;medication nonadherence;Modeling;Monitor;Morbidity - disease rate;mortality;Motivation;motivational enhancement therapy;multi-component intervention;Outcome;Patient Compliance;Patient Self-Report;Patients;Pharmaceutical Preparations;Pharmacy facility;point of care;pragmatic implementation;Prevalence;Primary Care;primary care clinic;primary care practice;primary care provider;primary care setting;primary outcome;Proctor framework;Provider;response;Role;screening;secondary outcome;side effect;Standardization;Structure;Surveys;team-based care;temporal measurement;Testing;Time;tool;Training;Update;uptake;user centered design;Work

PROJECT_TITLE: Addressing antihypertensive medication adherence through EHR-enabled teamlets in primary care - Resubmission - 1

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-H(02)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Genetics;Infectious Diseases;Inflammatory Bowel Disease

ORG_CITY: TUCSON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative Specialized membrane trafficking protects the intestinal epithelium from bacteria and viruses, as well as promotes barrier function of the intestine. However, our understanding of the machinery that regulates these processes is incomplete. Understanding these processes will provide insight into intestinal disease.

PI_NAMEs: WILSON, JEAN M (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: Autophagocytosis;Autophagosome;Bacteria;Biogenesis;Cell Physiology;cell type;Cells;Crohn's disease;Data;Development;Endosomes;endotubin;enteric pathogen;Enterocytes;Epithelial Cells;Epithelium;experimental study;Functional disorder;Genes;Genetic Transcription;Homeostasis;Impairment;Infection;Inflammatory Bowel Diseases;inhibition of autophagy;Innate Immune Response;insight;Integral Membrane Protein;Intestinal Diseases;intestinal epithelium;intestinal homeostasis;Intestines;Invaded;knock-down;Knock-out;Knowledge;Link;Lysosomes;Maintenance;Mediating;Mediator;Membrane;Messenger RNA;Metabolism;Mitochondria;Molecular;Monomeric GTP-Binding Proteins;Morphology;Mucosal Immunity;Mucous Membrane;mutant;Names;Natural Immunity;Organoids;pathogen;Pathway interactions;Patients;Persons;Phagocytes;Phagocytosis;Phagosomes;Predisposition;prevent;Process;Proteins;recruit;Regulation;Risk;risk variant;Role;Site;Structure;Testing;Tight Junctions;trafficking;transcriptome sequencing;Tubular formation;uptake;Variant;Vesicle;Virus;Work

PROJECT_TITLE: Autophagy and LC3-associated phagocytosis in intestinal epithelial cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-R(04)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Precision Medicine

ORG_CITY: Los Angeles

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Human tumors are complex mixtures of normal and tumor cells. We propose to develop a photolithographic system that integrates image analysis with 3D printing to isolate nearly pure (>90%) tumor DNA from human cancer sections on a microscope slide. Mutation detection is much easier with highly pure tumor DNA, which should improve the reliably and reproducibility of precision oncology.

PI_NAMEs: SHIBATA, DARRYL K (contact)

PROGRAM_OFFICER_NAME: CHUAQUI, RODRIGO F

PROJECT_TERMS: 3D Print;Algorithmic Analysis;Algorithms;anti-cancer research;Bioinformatics;Biological Markers;cancer cell;cancer diagnosis;cancer genome;cancer therapy;Cell Count;Cell Extracts;Cell Nucleus;Clinical;clinical translation;Complex;Complex Mixtures;cost;design;Diagnosis;Diploidy;DNA;DNA Methylation;DNA sequencing;Documentation;Engineering;Ensure;exome sequencing;Exposure to;Feedback;Gene Frequency;genetic variant;Genome;Gland;Goals;Heterozygote;Hour;Human;human DNA;Image;Image Analysis;improved;Individual;Intervention;Laboratories;laser capture microdissection;Learning;Location;Machine Learning;machine learning algorithm;Malignant neoplasm of lung;Malignant Neoplasms;Manuals;Masks;Measurement;Measures;Medical;Methods;Methylation;Microdissection;Microscope;Microscopic;Modernization;mortality;mutant;Mutation;Mutation Detection;neoplastic cell;next generation;next generation sequencing;Normal Cell;optimal treatments;Outcome;personalized medicine;Phenotype;Population;precision oncology;Printing;programs;Reproducibility;Research;Resolution;Robotics;Sampling;Scanning;Short Waves;skills;Slide;Specimen;Spottings;Stains;Standardization;success;System;targeted sequencing;targeted treatment;Technology;Testing;The Cancer Genome Atlas;Three-Dimensional Image;Tissues;Translations;tumor;tumor DNA;Tumor Tissue;Ultraviolet Rays;United States National Institutes of Health

PROJECT_TITLE: Photolithographic Tumor DNA Isolation


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: PROJECT NARRATIVE Proper genome integrity and stability are essential as aberrant alterations to genome folding and gene regulation are related to congenital malformations and cancer. The proposed research aims to characterize how parental contribution determines genome structure and function, which can ultimately impact organismal viability and disease susceptibility. This increased haplotype-specific knowledge may inform new strategies for personalized genomic medicine, including diagnosis, treatment, and prevention of human disease.

PI_NAMEs: ERCEG, JELENA  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Affect;Architecture;cell type;Cells;cellular imaging;Chromosomes;Congenital Abnormality;Development;developmental disease;Diagnosis;Diploidy;Disease;Disease susceptibility;fascinate;Gene Expression;Gene Expression Regulation;Genes;Genome;genome integrity;Genome Stability;genome-wide;Goals;Haplotypes;Heterogeneity;Heterozygote;Homologous Gene;human disease;Knowledge;Maintenance;Malignant Neoplasms;Organism;Parents;personalized genomic medicine;personalized strategies;Prevention;Process;Regulation;Research;Resolution;spatiotemporal;Structure;Tissues;Work

PROJECT_TITLE: Genome Folding and Regulation in Diploid Multicellular Organisms

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention

ORG_CITY: SAN DIEGO

ORG_NAME: SCRIPPS HEALTH

PHR: 8. Project Narrative Given the known serious consequences of uncontrolled blood sugars during hospitalization, this research proposes an alternative seamlessly integrates continuous glucose monitoring (CGM) in the hospital to test a dynamic and digitized, team-based approach to glucose management in an underserved and understudied, yet high-risk population. The Digital Dashboard is progressive, as it facilitates real-time, remote monitoring of a large volume of patients simultaneously; automatically identifies and prioritizes patients for intervention; and will detect any and all potentially dangerous hypoglycemic episodes in a hospital environment. Finally, our focus on clinical metrics (glucose control, infection) that are in-line with patient priorities and US hospital quality initiatives will increase relevance to healthcare systems and enhance incentive to adopt Cyber GEMS.

PI_NAMEs: FORTMANN, ADELAIDE L;PHILIS-TSIMIKAS, ATHENA  (contact)

PROGRAM_OFFICER_NAME: BURCH, HENRY B

PROJECT_TERMS: Adopted;Adoption;Adult;Advanced Practice Nurse;Algorithm Design;Algorithms;Ambulatory Monitoring;Blinded;Blood Glucose;blood glucose regulation;California;Cardiac;cardiometabolism;Clinical;clinical risk;Clinical Trials;cloud based;Communication;Computerized Medical Record;Continuous Glucose Monitor;Cost Analysis;cost effectiveness;Coupled;Dangerousness;dashboard;Data;design;Devices;diabetes control;Diabetes Mellitus;diabetes mellitus nursing;digital;digital monitoring;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;Eligibility Determination;Environment;Evaluation;Event;experience;Glucose;glucose monitor;glycemic control;Goals;Hand;Health Care Costs;Health system;Healthcare Systems;high risk;high risk population;Hispanic;Hispanic Populations;hospital care;hospital readmission;Hospitalists;Hospitalization;Hospitals;Human Resources;Hyperglycemia;Hypoglycemia;improved;improved outcome;Incentives;Infection;Infection Control;infection rate;infection risk;Infrastructure;innovation;Insulin;International;Intervention;Length of Stay;Low income;Maintenance;Methods;Mexico;Monitor;mortality;Neurologic;Non-Insulin-Dependent Diabetes Mellitus;Nosocomial Infections;Not Hispanic or Latino;Notification;novel;Nursing Staff;Outcome;Outcomes Research;Patients;Phase;point of care;point of care testing;Population;Populations at Risk;prevent;Process;Protocols documentation;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;remote monitoring;Research;Resources;safety net;Specialist;Standardization;Stratification;Stream;success;System;Telemetry;Testing;Time;transmission process;treatment as usual;treatment optimization;trend;wireless transmission;Work

PROJECT_TITLE: Continuous Glucose Monitoring for High-Risk Type 2 Diabetes in the Hospital:  Cloud-Based Real-Time Glucose Evaluation and Management System (Cyber GEMS)

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]


NIH_SPENDING_CATS: Asthma;Lung

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE We have discovered that the statin drugs (‘statins’) induce airway smooth muscle (ASM) relaxation in disease models of airway hypercontractility. We will investigate the mechanism(s) and therapeutic efficacy of this key observation, and establish that delivering statins by inhalation is effective and safe for the treatment of asthma.

PI_NAMEs: ZEKI, AMIR A. (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: 3-hydroxy-3-methylglutaryl-coenzyme A;Actins;Address;Adult;Agonist;airway hyperresponsiveness;airway inflammation;airway remodeling;Asthma;asthma exacerbation;asthmatic;Bronchoalveolar Lavage;Bronchoconstriction;Bronchodilator Agents;CCL26 gene;Cells;Chronic;Coenzyme A;Complex;constriction;cysteinyl leukotriene receptor;cytokine;Cytoskeletal Proteins;debilitating symptom;desensitization;disease model;Dyspnea;empowerment;experimental study;F-Actin;Functional disorder;Gene Silencing;Genes;geranylgeranyl pyrophosphate;Geranylgeranyl-diphosphate geranylgeranyltransferase;Goals;Histamine;House Dust Mite Allergens;Human;hydrophilicity;IL17 gene;IL6 gene;IL8 gene;Inflammation;Inhalation;inhibitor;Interleukin-13;knock-down;Leukotriene Antagonists;lipophilicity;Lung;Mass Spectrum Analysis;Measurement;Measures;Mediating;methacholine;Methods;mevalonate;mouse model;Mus;Muscarinic Antagonists;Muscle Contraction;Muscle relaxation phase;Muscle Tonus;myosin light chain 2;Myosin Light Chains;neonatal mice;optimal treatments;Oxidoreductase;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Phosphotransferases;Plasma;Predisposition;Production;Proliferating;Property;Proteins;rab GTP-Binding Proteins;receptor;Relaxation;respiratory smooth muscle;Rho-associated kinase;Role;Slice;small hairpin RNA;Smooth Muscle Myocytes;Stress Fibers;Stretching;Structure of parenchyma of lung;Symptoms;transcription factor;transcriptome sequencing;Treatment Efficacy

PROJECT_TITLE: Reducing Airway Smooth Muscle Tone Using Inhaled Statins

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Heart Disease - Coronary Heart Disease;Rural Health;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE A wave of rural hospital closures and acquisitions in the past decade may have reduced access to primary percutaneous coronary intervention for ST-Elevation Myocardial Infarction patients by disrupting transfer networks. We will use Medicare claims, original data on hospital closures and acquisitions, original survey data on emergency medical services pre-hospital STEMI treatment capabilities, and novel network analysis methods to estimate the effect of disruptions in STEMI transfer networks on through-network time to PCI (Aim 1), and choice of treatment and mortality (Aim 2). We will identify network characteristics that protect outcomes for ST-Elevation Myocardial Infarction patients after disruption (Aim 3) and quantify the role of disruptions in health disparities for ST-Elevation Myocardial Infarction patients (Aim 4). Our work will inform clinicians and policymakers about new ways to improve the health of rural Americans at risk for cardiovascular disease.

PI_NAMEs: NIKPAY, SAYEH SANDER (contact)

PROGRAM_OFFICER_NAME: SIDDIQUI, AYESHA SAEED

PROJECT_TERMS: Acceleration;Acute;Acute myocardial infarction;Address;Affect;Air;Area;Biometry;burden of illness;Cardiac;Cardiology;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;care delivery;care systems;Caring;Case Study;Characteristics;Collaborations;Data;data acquisition;data resource;Death Rate;design;Diagnosis;Disadvantaged;Disparity;Emergency medical service;Emergency Medicine;Event;experience;Face;Failure;Geographic Locations;Goals;Guidelines;Health;health disparity;Health Services Accessibility;Hospital Closures;Hospitals;improved;innovation;Link;Measures;Medical;Medicare;Medicare claim;Methods;Minnesota;mortality;Myocardial Infarction;Nature;novel;Outcome;Pathway Analysis;Patient Transfer;Patients;percutaneous coronary intervention;Physicians;Play;Policy Maker;preservation;promote resilience;Recommendation;Research;Research Project Grants;Resources;Risk Assessment;Role;Rural;rural Americans;rural area;Rural Health;rural health disparities;Rural Hospitals;rural patients;Rural Population;service providers;Stroke;Structure;Surveys;Techniques;Telemedicine;Tennessee;Testing;Time;Trauma;Travel;treatment choice;Treatment Protocols;trend;urban disparity;urban health disparities;web app;Work

PROJECT_TITLE: Disruptions in ST-Elevation Myocardial Infarction Transfer Networks and Cardiovascular Health of Rural Americans

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: SANTA BARBARA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: Health relevance. The long-term goal of this project is the development of wearable technology supporting the convenient, high-frequency, clinically-relevant measurement of electrolytes, metabolites, and drugs so providing providers and patients a real-time molecular window into health and treatment status.

PI_NAMEs: KIPPIN, TOD EDWARD;PLAXCO, KEVIN W (contact)

PROGRAM_OFFICER_NAME: MULVANEY, SHAWN PATRICK

PROJECT_TERMS: Address;Affinity;Amikacin;Ammonium;analog;Antibiotics;aptamer;Area;Binding;Biological Markers;Biomedical Research;Biotechnology;Blood Glucose;Brain;Cerebrospinal Fluid;Chemicals;Clinical;clinical decision-making;clinical practice;clinically relevant;Dangerousness;design;Development;Diabetes Mellitus;disease diagnosis;Dissociation;Dose;Dose Limiting;Drug Delivery Systems;drug efficacy;Drug Kinetics;Drug Monitoring;Electrolyte Balance;Electrolytes;Engineering;Ensure;Feedback;Frequencies;Funding;Generations;glucose monitor;Goals;Health;Hormones;Human;human subject;Hyponatremia;improved;In Situ;In Vitro;in vivo;Intercellular Fluid;interest;invention;Ions;Ligands;Lithium;Measurement;Measures;Medical;Medicine;Metabolism;Methods;Modeling;Molecular;Monitor;Needles;novel;Organ;Outcome;Patients;Performance;Peripheral;Pharmaceutical Preparations;Physiologic pulse;Plasma;Potassium;precision drugs;protein biomarkers;Proteins;Provider;rational design;Rattus;receptor;receptor binding;receptor sensitivity;Reporting;Research;Respiration;response;Safety;Scheme;sensor;Shapes;small molecule;Sodium;subcutaneous;success;Techniques;Technology;technology platform;Temperature;temporal measurement;Therapeutic;Therapeutic Index;Time;Tissues;Toxic effect;Validation;Veins;wearable device;Whole Blood;Work

PROJECT_TITLE: Harnessing cooperativity to achieve high-precision in vivo measurements

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Digestive Diseases;Infant Mortality;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: NEC is a serious intestinal disease that primarily affects preterm infants and is a leading cause of death among premature infants in the United States. In this project, we will address fundamental questions about why and how NEC occurs in a group of high risk premature babies upon postnatal exposure to NEC-associated environmental factors in combination with activation of antimicrobial immune responses. The knowledge generated is expected to pave the way for the development of novel therapies to prevent and treat NEC.

PI_NAMEs: TAN, XIAO-DI  (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Address;Affect;Animal Model;antimicrobial;Bacterial Infections;bacteriome;Bioinformatics;Birth;Cause of Death;Cells;Characteristics;chemokine;Coagulative necrosis;Complex;cytokine;cytotoxic;Data;Development;Disease;dysbiosis;Edema;Enterobacteriaceae;Enterotoxins;Environmental Risk Factor;Epithelial Cells;Event;Exhibits;Exposure to;Extremely Low Birth Weight Infant;Family;feeding;Gene Expression;Genes;Genetic Engineering;gut bacteria;gut colonization;gut dysbiosis;gut microbiota;Hemorrhage;high risk;high risk population;Human;Human Milk;ileum;Immune;Immune response;Immune system;Immunobiology;Immunologics;Impairment;In Vitro;in vivo;Infection;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Bowel Diseases;insight;Intestinal Diseases;intestinal epithelium;intestinal injury;Intestinal Mucosa;Intestines;Klebsiella;Klebsiella oxytoca;Knowledge;Lesion;Link;Lymphocyte;Macrophage Activation;Microbiology;microbiome;Modeling;Molecular;Molecular and Cellular Biology;Molecular Biology;mouse genetics;mouse model;Mucositis;Mucous Membrane;multidisciplinary;Mus;Natural Killer Cells;Necrotizing Enterocolitis;Neonatal;neonatal immune system;neonatal mice;neonate;novel;novel therapeutics;Organoids;Pathogenesis;Pathologic;Pathology;Phenotype;postnatal;premature;Premature Infant;preterm newborn;prevent;Prevention;Prevention strategy;Process;Proteins;pup;Reporting;Research;Research Personnel;response;Risk Factors;Role;Series;Signal Transduction;Small Intestines;STAT1 gene;Techniques;Testing;TLR4 gene;transcriptome sequencing;transcriptomics;treatment response;United States;Viral;virome;Virus;Virus Diseases;virus host interaction;Work

PROJECT_TITLE: Insights into a multi-hit process in the development of necrotizing enterocolitis

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Digestive Diseases;Drug Abuse (NIDA only);Health Services;Heart Disease;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Serious bacterial infections are among the most common medical complications of injection opioid use. Hospitalizations for these infections are common and represent opportunities for intervention. The proposed research is to develop a simulation model to project the long-term injection-related bacterial infections and overdose and assess the long-term clinical impact of novel hospital-based interventions that directly treat or modify risk associated with the underlying OUD.

PI_NAMEs: BAROCAS, JOSHUA ADAM (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: addiction;Address;Affect;Amputation;Applied Research;Attention;Bacterial Infections;Biometry;Cardiac Surgery procedures;Caring;Cessation of life;Chronic;Clinical;clinical decision-making;Clinical effectiveness;Clinical Research;Clinical Trials;combat;Communicable Diseases;community intervention;cost;cost effectiveness;Cost Effectiveness Analysis;Cost of Illness;cost outcomes;Data;design;Disease;Drug usage;economic evaluation;economic outcome;Education;Educational workshop;Effectiveness;Endocarditis;Ensure;Epidemic;Epidemiology;Evaluation;Evolution;experience;Fentanyl;Funding;Future;Goals;health care service utilization;health economics;Health Policy;Healthcare Systems;Hepatitis C virus;Heroin;high risk population;HIV;HIV/HCV;Hospitalization;Hospitals;Hygiene;improved outcome;Incidence;Infection;Infection prevention;Infectious Skin Diseases;Infective endocarditis;Injecting drug user;injection drug use;Injections;innovation;Intervention;Investigation;mathematical model;Mathematical Model Simulation;Measures;medical complication;medication for opioid use disorder;Medicine;Mentorship;Methodology;Methods;Modeling;models and simulation;mortality;multidisciplinary;Nature;Needles;non-opioid analgesic;novel;Opioid;opioid epidemic;opioid injection;opioid use;opioid use disorder;Oral Ingestion;Outcome;Overdose;Patients;Persons;Pharmaceutical Preparations;Population;Positioning Attribute;prescription opioid;prevent;preventive intervention;programs;Public Health;Quality of life;Relapse;Research;Research Personnel;Resources;Risk;Risk Factors;Risk Reduction;Sepsis;skill acquisition;skills;Skin;Soft Tissue Infections;Sterility;Stimulant;Structure;substance use;Time;tool;Training

PROJECT_TITLE: Strategies to reduce serious bacterial infections and overdose among people who inject drugs


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Social Determinants of Health

PHR: 8. PROJECT NARRATIVE A large body of evidence indicates that high-quality social relationships are correlated with decreased risk for morbidity and mortality from a range of disease outcomes and that poor-quality relationships or social disconnection are correlated with considerable risk for negative health outcomes. Although most of the work in this area is correlational in nature, it is often interpreted as if it is causal. This grant uses a genetically informed research design to help build an empirical foundation for public health intervention efforts around social relationships, health, and cognitive functioning that is based on strong causal inference.

PI_NAMEs: SBARRA, DAVID A (contact)

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: Acceleration;Address;Adult;Age;age acceleration;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Area;Behavioral Genetics;Cell Aging;Cognitive;cognitive function;cohort;coronavirus pandemic;Data;Data Collection;Data Set;Dementia;design;Disease Outcome;DNA Methylation;epidemiologic data;Epidemiology;Epigenetic age;epigenetic clock;epigenome-wide association studies;experience;field study;Foundations;gender difference;Grant;Health;Health behavior;Human;Impaired cognition;indexing;Individual;Learning;Literature;Loneliness;Marital Status;Marriage;Measures;Memory;men;Methods;Methylation;middle age;mild cognitive impairment;Modeling;Monozygotic twins;mood symptom;Morbidity - disease rate;mortality;Nature;neuroimaging;Neuropsychology;older adult;Outcome;Outcome Study;Participant;Pathway interactions;Patient Self-Report;Persons;Phenotype;poor health outcome;public health intervention;Records;Registries;Research;Research Design;Research Methodology;Research Personnel;Risk;satisfaction;Series;smartphone application;social;Social Behavior;Social Functioning;social integration;Social isolation;social relationships;Social support;sound;Testing;Time;Twin Multiple Birth;Twin Studies;Variant;Washington;Well in self;women's outcomes;Work

PROJECT_TITLE: Genetically Informed Studies of Social Connectedness and Health


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE We have created an innovative clinical and translational radiofrequency ablation (RFA) collaboration to study RFA in pancreatic ductal adenocarcinoma (PDAC). This proposal is a phase II single-arm clinical trial to evaluate outcomes using repeated Endoscopic ultrasound guided (EUS) RFA that leverages our strong clinical and preclinical platform to explore immunotherapy strategies in combination with RFA to improve clinical trials and overall survival for patients with PDAC. Thus, the proposed research is relevant to part of the NIH's mission that pertains to developing fundamental knowledge that will enhance health, lengthen life and reduce illness.

PI_NAMEs: LUNDBERG, JENNIFER BAILEY;THOSANI, NIRAV  (contact)

PROGRAM_OFFICER_NAME: VIKRAM, BHADRASAIN

PROJECT_TERMS: 5'-Nucleotidase;Ablation;Abscopal effect;Adenocarcinoma;Adenosine;Adoption;Animal Model;anti-PD-L1;anti-tumor immune response;Antitumor Response;arm;bench to bedside;cancer clinical trial;cancer diagnosis;cancer infiltrating T cells;cancer therapy;Cells;chemotherapy;Chemotherapy and/or radiation;Clinical;clinical care;Clinical Trials;Clinical Trials Design;clinically relevant;Coagulative necrosis;Collaborations;Collagen;Combination immunotherapy;Combined Modality Therapy;Contralateral;CXCR4 gene;Data;Deposition;Desmoplastic;Development;Diagnosis;Disease;Drug Delivery Systems;early phase clinical trial;Endoscopic Ultrasonography;Evaluation;Excision;Failure;Fibroblasts;Funding;Future;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Granzyme;Health;Hypoxia;Image;Immune;immune activation;immune checkpoint blockade;Immune checkpoint inhibitor;Immune Targeting;Immunologic Stimulation;immunomodulatory therapies;immunoregulation;Immunosuppression;Immunotherapy;improved;improved outcome;in vivo;Incidence;Infrastructure;inhibitor;innovation;Institution;Knowledge;Life;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Mediating;minimally invasive;Mission;Modeling;Monitor;Mus;neovascularization;novel;novel therapeutic intervention;Outcome;Pancreatic duct;Pancreatic Ductal Adenocarcinoma;participant enrollment;Patient-Focused Outcomes;Patients;Phase;phase 2 study;Phase II Clinical Trials;pre-clinical;Pre-Clinical Model;primary outcome;programmed cell death ligand 1;programs;public health relevance;Publishing;Radiofrequency Interstitial Ablation;Research;Research Personnel;Resectable;Resected;response;response biomarker;revascularization;Safety;safety and feasibility;secondary outcome;Serum;single-cell RNA sequencing;Site;standard of care;Stromal Cell-Derived Factor 1;subcutaneous;success;survival outcome;Survival Rate;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapy resistant;TNFRSF5 gene;transcriptomics;treatment response;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Tissue;tumor-immune system interactions;United States National Institutes of Health;Unresectable

PROJECT_TITLE: A single-arm phase II study to evaluate the safety and efficacy of combination systematic chemotherapy and multiple rounds of endoscopic ultrasound-guided radiofrequency ablation in pancreatic cancer

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative The proposed research will investigate RNA-protein interactions that are essential for healthy cells and will allow us to better understand how mutations in these systems result in genetic disorders and diseases. For example, defects in the U6 small nuclear ribonucleoprotein particle cause the genetic disorder poikiloderma with neutropenia and mutations in the Lsm1 RNA binding protein gene cause severe developmental delays and congenital defects. We are also studying the interaction of poly-UG (pUG) RNA with the protein TDP-43, which is associated with the neurodegenerative diseases amyotrophic lateral sclerosis, frontoral lobe dementia and Alzheimer’s.

PI_NAMEs: BUTCHER, SAMUEL E (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Alternative Splicing;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Animals;Area;Binding;Biological;Biology;biophysical techniques;Biophysics;Cells;cofactor;Complex;Congenital Abnormality;Data;Defect;Dementia;Developmental Delay Disorders;Essential Genes;Eukaryotic Cell;Gene Expression;Gene Proteins;Gene Silencing;Genetic Diseases;Human;in vivo;Introns;Investigation;Length;Lobe;Memory;Messenger RNA;Molecular;mRNA Decay;mRNA Precursor;Mutation;Nematoda;Neurodegenerative Disorders;Neurons;Neutropenia;Outcome;Pathway interactions;Phase Transition;posttranscriptional;protein complex;protein TDP-43;Proteins;Recycling;Research;RNA;RNA Folding;RNA Interference;RNA Splicing;RNA-Binding Proteins;RNA-Protein Interaction;small molecule;Small Nuclear Ribonucleoproteins;Spliceosome Assembly Pathway;Spliceosomes;Structure;System;Tail;Testing;transgenerational epigenetic inheritance;U4 Small Nuclear Ribonucleoproteins;U6 Small Nuclear Ribonucleoproteins

PROJECT_TITLE: Biophysical investigations of RNA complexes essential for gene expression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Parkinson's Disease;Rare Diseases

PHR: Project Narrative: Protein aggregation is a recalcitrant problem in the purification of valuable proteins for basic science and industry as well as in several fatal neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), an Alzheimer's Disease-Related Dementia (ADRD). Our studies will enable a high-resolution mechanistic understanding of Hsp104 and Skd3, two enzymes that reverse aberrant protein aggregation. Realization of our goals will enable potentially transformative solutions to reverse protein aggregation in diverse neurodegenerative diseases, including ALS/FTD and other ADRDs, and allow facile purification of aggregation-prone proteins for critical basic, biotechnological, or pharmaceutical purposes.

PI_NAMEs: SHORTER, JAMES  (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Address;alpha synuclein;Alzheimer's disease related dementia;Amyloid;amyloidogenesis;ATP Hydrolysis;ATP phosphohydrolase;Basic Science;Binding;Biological Assay;Biotechnology;Cells;Collaborations;combat;Couples;Cryoelectron Microscopy;Curiosities;Data;Deuterium;Development;Directed Molecular Evolution;Disease;disease model;Dissociation;empowerment;Engineering;Enzymes;Eukaryota;Exhibits;frontotemporal lobar dementia amyotrophic lateral sclerosis;Goals;Homologous Gene;Human;Hydrogen;Industry;Link;Mass Spectrum Analysis;Medicine;Mitochondria;Mutation;nanomachine;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;novel;novel therapeutics;Nucleotides;Orthologous Gene;Parkinson Disease;Pharmacologic Substance;protein aggregation;Protein Biochemistry;protein folding;protein misfolding;protein TDP-43;Proteins;Rattus;Research;Resolution;Secure;Shapes;Structure;Substantia nigra structure;Substrate Specificity;Technology;Therapeutic;Therapeutic Agents;translocase;Variant

PROJECT_TITLE: Defining mechanisms of AAA+ disaggregases

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Pain Research;Patient Safety;Precision Medicine

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE  Patients with cancer represent one of the most vulnerable populations within our healthcare system, as treatment regimens and the attendant toxicities of (or lack of response to) therapies place cancer patients at high risk for adverse outcomes. The use of germline pharmacogenomic information offers a potential solution to better inform therapeutic decision-making. In this project, we posit that preemptive genotyping and point-of- care availability of pharmacogenomic information offers the potential to improve cancer care by identifying individuals at increased risk for adverse drug outcomes, allowing upfront tailored chemotherapy dosing and analgesic medication choices.

PI_NAMEs: O'DONNELL, PETER HUGH (contact)

PROGRAM_OFFICER_NAME: CHANG, CHRISTINE Q

PROJECT_TERMS: Address;Adopted;Adoption;Adverse event;adverse outcome;Analgesics;arm;breast malignancies;cancer care;cancer initiation;cancer pain;Cancer Patient;cancer risk;cancer therapy;cancer type;Caring;Cessation of life;chemotherapy;Chemotherapy-Oncologic Procedure;Chicago;Childhood Leukemia;Clinical;clinical application;clinical decision support;clinical translation;Codeine;Data;Decision Making;Diagnosis;Discipline;Dose;Education;Effectiveness;Emergency department visit;Evolution;expectation;experience;Face;fluoropyrimidine;Fostering;Future;gastrointestinal;Genomic medicine;Genomics;Genotype;Germ Lines;Germ-Line Mutation;Goals;Head and neck structure;Healthcare Systems;high risk;Hospitalization;Hydrocodone;improved;Incidence;Individual;individualized medicine;Infrastructure;Institution;Intervention;irinotecan;Knowledge;Life;Malignant Neoplasms;Medical;Mission;Nature;Oncologist;Oncology;Opioid;Outcome;Pain;Pain management;pain relief;Patient Recruitments;Patient-Focused Outcomes;Patients;Pattern;Perception;personalized chemotherapy;Pharmaceutical Preparations;Pharmacogenomics;pharmacologic;point of care;Population;Pragmatic clinical trial;prescription opioid;prevent;primary endpoint;Process;prospective;Public Health;Quality of life;Randomized;Recommendation;Reporting;Research;response;Risk;Safety;shared decision making;side effect;standard of care;Supportive care;System;Technology;Testing;Therapeutic;tool;Toxic effect;Tramadol;translational genomics;treatment as usual;treatment choice;Treatment Protocols;Treatment-related toxicity;UGT1A1 gene;Universities;Variant;Vulnerable Populations

PROJECT_TITLE: Pharmacogenomics to Catalyze Decision Support in Oncology Care


NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: CLEVELAND

ORG_DEPT: NEUROSCIENCES

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The proposed project is relevant to public health because neurological gait disorders are common among older adults and pose a serious risk of falls, the leading cause of injury-related death among Americans over 60. This work will study how motor cortex generates neural signals that control skilled walking by isolating the contribution of the cerebellum and posterior parietal cortex to these signals. The project is relevant to the NIH mission because a data-driven model of how motor cortical dynamics are generated is expected to accelerate the improvement of deep brain stimulation approaches and brain-machine interfaces for movement disorders.

PI_NAMEs: SAUERBREI, BRITTON ALAN (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Acceleration;Aging;American;Animals;Area;Attenuated;Behavior;Behavioral;Brain;brain machine interface;Brain region;Cell Nucleus;Cerebellum;Characteristics;Complex;Computational Technique;Data;Data Analyses;data-driven model;Deep Brain Stimulation;dimension reduction;Dimensions;Disease;dynamic system;Environment;Exhibits;Extensor;Failure;fall risk;falls;flexibility;Flexor;Foundations;Future;Gait;Generations;Goals;Healthcare Systems;Impairment;improved;Individual;inhibitory neuron;injury-related death;innovation;kinematics;Knee;Knowledge;Left;Lesion;limb movement;Limb structure;Locomotion;Locomotor adaptation;Measurement;Measures;Mission;Modeling;Modification;Motor;motor control;Motor Cortex;Motor Skills;Movement;Movement Disorders;Mus;Muscle;Nervous System;neural;neural circuit;Neurodegenerative Disorders;Neurologic Gait Disorders;Neurons;neurotransmission;older adult;optogenetics;Output;Parietal;Parietal Lobe;Pattern;Phase;Population;Population Dynamics;Public Health;Pump;Purkinje Cells;Research;Signal Transduction;skills;Source;Spinal;Surface;synergism;Techniques;Testing;Thalamic structure;Time;treadmill;United States National Institutes of Health;Walking;Work

PROJECT_TITLE: Generation of Motor Cortical Dynamics Controlling Skilled Locomotion

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Successful aging in the home can greatly improve quality of life, improve health outcomes, and reduce burden on the healthcare system. The goal of this project is to establish a national collaboratory for the development, evaluation, and implementation of artificial intelligence software and new technologies to facilitate health aging in the home. The collaboratory will include a diversity of experts including clinicians, computer scientists, engineers, patients, and caregivers to facilitate this goal.

PI_NAMEs: DEMIRIS, GEORGE  (contact);KARLAWISH, JASON H;MOORE, JASON H.

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Adult;Aging;aging in place;Alzheimer's Disease;Alzheimer's disease related dementia;Artificial Intelligence;artificial intelligence method;artificial intelligence model;Caregivers;Clinical;clinical care;Clinical Data;clinical decision support;clinical translation;collaboratory;Collection;commercialization;Communication;community based service;computer scientist;Computer software;computerized data processing;Data;data pipeline;Decision Support Model;Development;Electronic Health Record;Engineering;Ethics;Evaluation;experience;Family;Feedback;Funding;Goals;Grant;Health;Healthcare Systems;healthy aging;Home;Home environment;improved;Industry;industry partner;innovative technologies;Insurance;Lead;Managed Care;member;Mission;Monitor;new technology;older adult;Outcome;Patients;Pilot Projects;point of care;Policies;Process;Program Development;programs;Quality of life;Regulation;Rural;Rural Population;Science;skills;success;synergism;Technology;tool;Training;translational potential;Translations;Underserved Population;Validation;Vision;Work

PROJECT_TITLE: Penn Artificial Intelligence and Technology Collaboratory for Healthy Aging


NIH_SPENDING_CATS: Aging;Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PHR: Successful aging in the home can greatly improve quality of life, improve health outcomes, and reduce burden on the healthcare system. The goal of this project is to establish a national collaboratory for the development, evaluation, and implementation of artificial intelligence software and new technologies to facilitate health aging in the home. The administrative core will facilitate scheduling, logistics, event planning, communication, computer programming, and web design.

PI_NAMEs: MOORE, JASON H. (contact)

PROJECT_TERMS: Adult;Advertising;Advisory Committees;Aging;Alzheimer's disease related dementia;American;Artificial Intelligence;Awareness;biomedical informatics;Collaborations;collaboratory;commercialization;Communication;Community Developments;computer program;Computer software;Consumption;design;Development;Discipline of Nursing;Evaluation;Event;experience;Funding;Goals;Graduate Education;Grant;Health;Health Policy;Healthcare Systems;healthy aging;Home;improved;industry partner;Informatics;innovative technologies;Institution;interest;Internet;knowledge integration;Lead;Leadership;Logistics;Machine Learning;Medical Ethics;Medical Informatics;medical schools;Medicine;meetings;Memory;Methods;Neurology;new technology;Newsletter;Outcome;outreach;Pennsylvania;Pilot Projects;Positioning Attribute;professor;programs;Quality of life;Research Institute;Research Support;Resources;Role;Schedule;Schools;skills;success;Technology;technology development;Time;Training and Education;Universities;Update;web site

PROJECT_TITLE: Admin-Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Rural Health

PHR: The PennAITech Collaboratory supports the development, evaluation, and implementation of artificial intelligence software and new technologies to facilitate healthy aging in the home. The goal of the Stakeholder Engagement Core is to ensure that technology solutions and artificial intelligence approaches proposed and developed by the PennAITech Collaboratory are maximally adoptable by and accessible to their end users by soliciting ongoing stakeholder input and involving all key parties throughout all phases of the development and testing processes.

PI_NAMEs: DEMIRIS, GEORGE  (contact)

PROJECT_TERMS: Administrator;Adopted;Aging;Alzheimer's disease related dementia;Appointment;Artificial Intelligence;Capital;Caring;Collaborations;collaboratory;commercialization;Communities;Community Health Education;Computer software;design;Development;Discipline of Nursing;Educational workshop;Elderly;empowerment;Evaluation;Family;Funding;Geriatrics;Goals;Health;Health Professional;Health system;Healthcare;healthy aging;Home;improved;informal caregiver;innovation;Joints;Knowledge;knowledge translation;Leadership;Learning;Medical;medical schools;member;Modeling;Monitor;new technology;Nurses;Nursing Homes;older adult;Outcome;Patient Education;Pennsylvania;Persons;Phase;Physicians;Pilot Projects;Policy Maker;preservation;Primary Care;Process;Production;profession allied to medicine;professor;programs;Rehabilitation therapy;Renaissance;Research;Research Personnel;Role;rural area;School Nursing;Self Determination;Series;smart home;social assistive robot;Technology;technology platform;technology validation;Testing;tool;underserved area;United States Health Resources and Services Administration;Universities;Work

PROJECT_TITLE: Stakeholder Engagement Core


NIH_SPENDING_CATS: Bioengineering;Regenerative Medicine

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative Cell-cell signaling has essential roles in development, tissue maintenance, and regeneration, and many of the same signaling pathways are implicated in cancers and other diseases. The proposed research seeks to understand fundamental cell-biological mechanisms that control how signaling proteins move between cells and how cells interpret this information to give rise to spatial organization and cellular behaviors. This work will advance our understanding of essential molecular and cellular processes relevant to development, homeostasis, and regenerative medicine, along with diseases related to abnormal cell signaling.

PI_NAMEs: PANI, ARIEL MATTHEW (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Abnormal Cell;Adult;Animals;Architecture;base;Behavior;Biological;Caenorhabditis elegans;cell behavior;cell motility;Cell Physiology;Cells;Cellular biology;Characteristics;Communication;Destinations;Development;Disease;Extracellular Protein;Foundations;Genome engineering;Goals;Health;Homeostasis;Human;Image;in vivo;insight;intercellular communication;Knowledge;Maintenance;Malignant Neoplasms;Methods;migration;Modeling;Molecular;Morphogenesis;Natural regeneration;Nerve;novel;Pattern;Process;Program Description;programs;Proteins;Regenerative Medicine;Research;Role;Signal Pathway;Signal Transduction;Signaling Protein;Speed;System;Time;Tissue Engineering;Tissues;ultra high resolution;WNT Signaling Pathway;Work

PROJECT_TITLE: Dissecting the cell-biological foundations of developmental cell signaling in a living animal

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Data Science;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative

ORG_CITY: PHILADELPHIA

PHR: Successful aging in the home can greatly improve quality of life, improve health outcomes, and reduce burden on the healthcare system. The goal of the overall project is to establish a national Collaboratory for the development, evaluation, and implementation of artificial intelligence software and new technologies to facilitate health aging in the home. The Technology Identification and Training Core (Core C) is proposed to advance the goal of the Collaboratory by identifying new AI algorithms and technology based on the needs of aging Americans and developing training opportunities to facilitate their adoption and use in the pilot funding programs.

PI_NAMEs: SHEN, LI  (contact)

PROJECT_TERMS: Academia;Address;Adoption;Adult;Aging;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;American;Area;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence method;Big Data;Biomedical Engineering;biomedical informatics;Caregivers;Caring;Categories;central database;Clinical;Collaborations;collaboratory;commercialization;Communication;Communities;Computer software;course module;Data;Databases;Dementia;Development;Education;Educational process of instructing;Educational workshop;Engineering;Evaluation;Event;Feedback;Funding;Funding Opportunities;Goals;Grant;hackathon;Health;health disparity;Healthcare Systems;healthy aging;Home;Home environment;Human;Image Analysis;Impaired cognition;improved;Industry;Informatics;innovation;innovative technologies;knowledge base;Learning;Literature;Machine Learning;Medical;meetings;Mentors;Methods;Mission;Monitor;Natural Language Processing;new technology;news;older adult;online course;Outcome;patient home care;Patients;Physicians;Policy Maker;professor;programs;Quality of life;Research;Resources;Scientist;social media;summer institute;Surveys;Technology;technology training;text searching;Training;Training Activity;training opportunity;Training Support;United States National Institutes of Health;Update;web portal;web site;webinar;Work


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: RALEIGH

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: Project Narrative The complex biomedical research questions of today require scientists to have both specialized expertise in their field and also the skills to bridge that expertise across fields in a team science environment; however, most graduate training focuses exclusively on the development of specialized expertise. The interface between chemistry and biology is one of the most common and important intersections of fields, playing a key role in everything from basic fundamental discoveries to advanced pharmaceutical development. The Chemistry of Life Training Program will complement NC State’s existing doctoral programs in in the molecular sciences, by providing trainees with the technical skills, mentorship, and professional development needed to cross the Chemistry: Biology interface, producing a new generation of scientists prepared to tackle the most complex biomedical issues.

PI_NAMEs: PIERCE, JOSHUA G. (contact)

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TERMS: Chemistry;Life;Training Programs

PROJECT_TITLE: NC State Chemistry of Life Training Program (CLTP)

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Data Science;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention;Rehabilitation;Rural Health;Social Determinants of Health

PHR: Successful aging in the home can greatly improve quality of life, improve health outcomes, and reduce burden on the healthcare system. The goal of this project is to establish a national collaboratory for the development, evaluation, and implementation of artificial intelligence software and new technologies to facilitate health aging in the home. The goal of the Clinical Translation and Validation Core is to use the science and practice of geriatrics and gerontology to assess the feasibility and clinical utility of artificial intelligence (AI) methods for clinical decision support and of new technology for monitoring aging adults in their homes.

PI_NAMEs: KARLAWISH, JASON H (contact)

PROJECT_TERMS: Address;Adopted;Adoption;Adult;Aging;Alzheimer's Disease;Alzheimer's Disease Core Center;Alzheimer's disease related dementia;Area;Artificial Intelligence;artificial intelligence method;artificial intelligence model;Belief;Biological Markers;biomedical informatics;Board Certification;Caring;Civil Rights;Clinical;clinical care;clinical decision support;clinical translation;Collaborations;collaboratory;Communities;Computer software;Data;Databases;Decision Making;dementia care;design;Detection;Development;Diagnostic;digital;Elderly;Electronic Health Record;Engineering;Epidemiology;Ethics;Evaluation;experience;Family;Feedback;Functional impairment;Geriatrics;Gerontology;Goals;Grant;Health;Health Policy;Healthcare;Healthcare Systems;healthy aging;Home;Impaired cognition;improved;innovation;instrumental activity of daily living;interest;Leadership;machine learning model;Medical Ethics;Medical Informatics;Medicine;Memory;Mentors;Modeling;Monitor;Neurology;new technology;Nursing Informatics;older adult;open source;Outcome;patient home care;Persons;Philadelphia;Pilot Projects;predict clinical outcome;Predictive Analytics;prevent;Prevention;professor;Quality of life;Research;Research Personnel;Resources;Role;Rural;Rural Population;Safety;Science;searchable database;Site;smart home;social stigma;socioeconomics;software development;Specialist;Syndrome;synergism;Technology;tool;Training;Training Support;Underserved Population;Validation;Voting Right;wearable device;Work


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases

ORG_CITY: SAN MARCOS

ORG_NAME: TEXAS STATE UNIVERSITY

PHR: Public Health Statement: Bim1 is linked to increased virulence for Cryptococcus neoformans in a mouse meningitis infection model and participates in Cu-homeostasis. Related BLP genes are also present in several fungal pathogens affecting humans, including Coccidioides immitis, Histoplasma capsulatum, Talaromyces marneffei, and Aspergillus niger but little is known about how BLP sequence variation affects biological function. In the proposed research project, we will explore the active site design of this novel class of BLP copper trafficking proteins and explore their mechanism for Cu-delivery at the fungal cell surface; ultimately our findings will lead to a deeper understanding of the mechanisms of copper homeostasis in fungi which may be exploited for the development of future antifungal treatment strategies.

PI_NAMEs: PETERSON, RYAN LOREN (contact)

PROGRAM_OFFICER_NAME: ZHOU, YANG

PROJECT_TERMS: Active Sites;Affect;Affinity;Alleles;Amino Acid Sequence;anti-fungal agents;Ascomycota;Aspergillus niger;Basidiomycota;Binding;Binding Proteins;Biochemical;Biological Availability;Biological Process;Biology;Brain;C-terminal;Carrier Proteins;Cell membrane;Cell surface;Cell Wall;Coccidioides immitis;Coenzymes;Copper;copper-binding protein;Cryptococcus neoformans;Cytoplasm;Data;design;Development;Documentation;Drug Metabolic Detoxication;Electron Spin Resonance Spectroscopy;Electronics;Ensure;Environment;experimental study;extracellular;Extracellular Protein;Family;fungus;Future;Gene Proteins;Genetic;Genome;Goals;GPI Membrane Anchors;Health;Histoplasma capsulatum;Homeostasis;Homologous Gene;Homologous Protein;host colonization;Human;Infection;innovation;insight;Investigation;Ions;Kinetics;Ligand Binding;Link;Location;Lytic;man;Meningitis;Metals;Micronutrients;Mitochondria;Mixed Function Oxygenases;Modeling;Mus;novel;Outcome;oxidation;Oxidation-Reduction;Oxidative Stress;Oxygenases;pathogenic fungus;Pathway interactions;Pattern;Pichia;Plasma Cells;Polysaccharides;Process;Production;Property;protein expression;Protein Family;Protein Isoforms;protein transport;Proteins;prototype;Public Health;Pulse Radiolysis;Recombinants;Reporting;Research;Research Project Grants;Resistance;Respiration;Role;Saccharomyces cerevisiae;Sequence Analysis;Sequence Homology;Signal Transduction;Signaling Molecule;Site;small molecule;Solid;Source;Specificity;Superoxides;System;Talaromyces;Testing;trafficking;treatment strategy;uptake;Variant;virtual;Virulence;Work;Yeasts

PROJECT_TITLE: Mechanisms for cellular copper import via secreted cuproproteins


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PHR: Successful aging in the home can greatly improve quality of life, improve health outcomes, and reduce burden on the healthcare system. The goal of the overall project is to establish a national collaboratory for the development, evaluation, and implementation of artificial intelligence software and new technologies to facilitate health aging in the home. The Networking and Mentoring Core (Core E) is will organize networking, mentoring, and dissemination opportunities for the awardees of the pilot programs.

PI_NAMEs: RITCHIE, MARYLYN D (contact)

PROJECT_TERMS: Academia;Adult;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;American;Artificial Intelligence;artificial intelligence method;Bioinformatics;biomedical informatics;Businesses;Capital;collaboratory;commercial application;commercialization;Communication;Communities;Computer software;Data;design;Development;Discipline;Environment;Evaluation;Event;experience;Family;Fostering;Goals;Health;Healthcare Systems;healthy aging;Home;Home environment;improved;Individual;Industry;industry partner;Infrastructure;innovation;Institution;interest;Investments;Lead;member;Mentors;Methodology;Minority Groups;Monitor;new technology;next generation;older adult;Online Systems;Outcome;Paper;peer;Pennsylvania;Pilot Projects;Positioning Attribute;precision medicine;programs;Publications;Qualifying;Quality of life;real world application;Research Infrastructure;Research Personnel;Research Support;Role;Rural;Safety;Scientist;Series;social media;Technology;tool;Translations;Underrepresented Minority;Universities

PROJECT_TITLE: Networking and Mentoring Core


NIH_SPENDING_CATS: Microbiome;Sleep Research

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative RELEVANCE TO PUBLIC HEALTH: This project will clarify the characteristics of circadian systems that enhance fitness. Biological clocks have been found to be crucial for physical and mental health; cancer, growth/proliferation, metabolic disorders, cardiovascular disease, and depression are associated with the disruption of these timing systems by genetic and/or environmental disturbance (i.e., by shiftwork or "jet-lag"). Understanding the crucial features of biological timing that are selected by rhythmic environments will reveal underlying circadian organization & regulation to assist the development of therapies to properly phase sleep, enabling us to improve the health, performance, and well-being of humans suffering from mental and/or metabolic disorders.

PI_NAMEs: JOHNSON, CARL HIRSCHIE (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Address;alertness;Antibiotics;Bacteria;Bacterial Model;Biochemical;Biochemical Reaction;Bioinformatics;Biological;Biological Clocks;Biological Models;Biological Process;Cardiovascular Diseases;cell community;cell growth regulation;Cell Line;Cell Physiology;Cells;Characteristics;circadian;circadian pacemaker;circadian regulation;Circadian Rhythms;cold stress;Compensation;Complex;Cyanobacterium;Dimensions;Disease;Environment;Environmental Risk Factor;Escherichia coli;Event;Evolution;feeding;Feeding Patterns;fitness;fitness test;Frequencies;Future;Gene Expression;Gene Structure;Genes;Genetic;Genomics;Goals;Growth;gut microbiome;Health;Homeostasis;Hormones;host-microbe interactions;Hour;Human;improved;information processing;Jet Lag Syndrome;Knowledge;Malignant Neoplasms;Mental Depression;Mental disorders;Mental Health;Metabolic Diseases;Metabolism;Metagenomics;microbiome;Molds;Molecular;Mutation;Natural Selections;Network-based;novel;Organism;Performance;Periodicity;Personal Satisfaction;Phase;Photoperiod;photoperiodicity;physical conditioning;pressure;Process;progenitor;Proliferating;Property;Protocols documentation;Public Health;Recovery;Regulation;response;Role;Seasons;shift work;Signal Transduction;Sleep;System;Temperature;temporal measurement;Testing;therapy design;therapy development;Time;transcriptome;transcriptomics

PROJECT_TITLE: Regulation and Significance of Sustained Circadian Oscillations

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


PHR: AD/ADRD Focus Pilot Core (Core F) Project Narrative The overarching goal of the Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD) Focus Pilot Core (Core F) is to promote the advancement of science for predictive analytics, for clinical decision support, or for the care of adults with AD/ADRD. Led by Dr. Graciela Gonzalez-Hernandez, Associate Professor of Informatics and Senior Faculty of the Institute of Biomedical Informatics (IBI) at the University of Pennsylvania, and Director of the Health Language Processing (HLP) Center, Core F seeks to provide comprehensive, integrated, and continuous support and promotion of Pilot projects that connect novel technologies for monitoring aging adults in the home with research activities and clinical care, specifically aimed at addressing the acute needs of the AD/ADRD patients and their caregivers and the specific nuances and progression of AD/ADRD. To our knowledge, a comprehensive pipeline from home to clinic and back that addresses the many challenges of AD/ADRD does not yet exist and building and extending this pipeline will be central to our pilot funding program.

PI_NAMEs: GONZALEZ HERNANDEZ, GRACIELA  (contact)

PROJECT_TERMS: Acute;Address;Adoption;Adult;Aging;aging in place;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Arizona;Artificial Intelligence;artificial intelligence model;Back;biomedical informatics;Biostatistics Core;career;Caregivers;Caring;Clinic;Clinical;clinical care;Clinical Data;clinical decision support;clinical research site;clinical translation;Collaborations;collaboratory;Communities;community organizations;Computer software;cooperative study;data integration;Database Management Systems;design;Development;Diagnosis;Education;Educational workshop;Engineering;Equity;Ethics;Experimental Designs;Feedback;Fostering;Funding;Goals;Health;Health Services Accessibility;Health system;healthy aging;Home;human capital;Industry;Informatics;innovation;innovative technologies;Institution;Journals;language processing;Link;Machine Learning;member;Mentors;Methodology;Methods;mid-career faculty;Mission;Monitor;Names;neuroimaging;new technology;novel;Patients;peer networks;Pennsylvania;Pilot Projects;point of care;Policies;Predictive Analytics;Preparation;Process;Production;programs;provider networks;Publications;Request for Proposals;Research;Research Activity;Research Personnel;Science;senior faculty;Series;Site;software systems;Students;Study Section;success;Supervision;symposium;synergism;Technology;Testing;Training;United States National Institutes of Health;United States National Library of Medicine;Universities;Validation

PROJECT_TITLE: AD/ADRD Pilot Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetics;Hydrocephalus;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Program Director/Principal Investigator (Last, First, Middle): Teich, Andrew, Franklin Project Narrative Alzheimer’s disease (AD) is the number one cause of dementia in the western world, and is a major cause of mortality and morbidity. Brain inflammation involving cells called microglia has recently been recognized as an important component of AD, although how microglia contribute to dementia is not completely clear. This proposal will lead to a better understanding of the types of microglia that are active in brain tissue from patients with early AD pathology, and link this to biomarkers in cerebral spinal fluid that may be useful for predicting clinical outcomes. OMB No. 0925-0001/0002 (Rev. 03/16 Approved Through 10/31/2018) Page Continuation Format Page

PI_NAMEs: MCKHANN, GUY M;TEICH, ANDREW FRANKLIN (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Age;aging population;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid;Autopsy;Biological Markers;Biopsy;Blood;Brain;Brain Pathology;brain tissue;Categories;Cells;Cerebrospinal Fluid;Chronic;Clinical;clinical outcome measures;Cognitive;comorbidity;Data;Dementia;density;Deposition;Elderly;Encephalitis;Enzyme-Linked Immunosorbent Assay;Etiology;Frequencies;Future;Gene Cluster;Gene Expression;Genes;Genetic;Genetic Markers;genome wide association study;Goals;Grant;Histologic;Human;Hydrocephalus;Image;Immune response;Impaired cognition;Investigation;Link;Literature;Measures;Microglia;Morbidity - disease rate;Morphologic artifacts;mortality;Mus;Normal Pressure Hydrocephalus;older patient;Operative Surgical Procedures;Outcome;Pathology;Patients;Physiology;Population;potential biomarker;predict clinical outcome;predictive marker;predictive signature;Predictive Value;Principal Investigator;programs;Proteins;Proteomics;reduce symptoms;Reporting;response;Senile Plaques;Shunt Device;spatial relationship;Specimen;Symptoms;tau Proteins;tau-1;Testing;Time;Tissues;transcriptome sequencing;Ventricular;Visualization;Western World;Work

PROJECT_TITLE: An investigation of Alzheimer's Disease pathology, microglial immune response, and CSF proteomics in normal pressure hydrocephalus patients

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: NARRATIVE Klebsiella pneumoniae is a common cause of pneumonia and sepsis that contributes to high mortality and morbidity in hospitalized, immunosuppressed, and chronically ill patients. Additionally, multidrug resistant K. pneumoniae are a major public health concern. The goal of this proposal is to develop a non-transmissible live attenuated K. pneumoniae vaccine to prevent infection with K. pneumoniae.

PI_NAMEs: BALIBAN, SCOTT M. (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Address;Aerosols;Anabolism;Animals;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;Antigens;antimicrobial;Antimicrobial Resistance;Arabinose;Attenuated;Attenuated Vaccines;attenuation;attributable mortality;authority;Bacteria;Bacterial Vaccines;Bronchoalveolar Lavage Fluid;capsule;carbapenem-resistant Enterobacteriaceae;Carbapenems;Centers for Disease Control and Prevention (U.S.);Cessation of life;Chronically Ill;Classification;cross immunity;Development;efficacy study;Environment;experimental study;Genes;Genetic Engineering;Goals;Growth;Guanine;Harvest;Hospitalization;Human;IL17 gene;Immune response;Immune system;Immunize;immunogenic;immunogenicity;Immunoglobulin A;Immunoglobulin G;immunosuppressed;improved;In Vitro;in vivo;Individual;Infection;Infection prevention;Inhalation;Interruption;Kinetics;Klebsiella pneumoniae;Lethal Dose 50;Lipopolysaccharides;Measures;Mediating;Morbidity - disease rate;mortality;Mucosal Immune Responses;Multi-Drug Resistance;Mus;Oral;pathogen;Patients;Pneumonia;Polysaccharides;preclinical safety;Production;promoter;protective efficacy;Public Health;Reporting;Resistance;resistant Klebsiella pneumoniae;response;Safety;safety study;Salmonella typhimurium;Sepsis;Serotyping;Serum;SS DNA BP;Tissues;transmission process;Vaccination;vaccine candidate;Vaccines;Virulence

PROJECT_TITLE: Live attenuated non-transmissible (LANT) Klebsiella pneumoniae vaccines

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]