NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cannabinoid Research;Clinical Research;Electronic Nicotine Delivery Systems;Pediatric;Prevention;Substance Misuse;Tobacco

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: Recent changes in the tobacco and cannabis regulatory and product landscapes and the extraordinary popularity of vaping products among young people have led to significant changes in how these drugs are used independently and in combination. Yet, very little is known about daily patterns and correlates of nicotine and/or cannabis vaping. This innovative study will use Ecological Momentary Assessment (EMA) and longitudinal survey data to examine distal (adolescent) and near-term (e.g., within-day situational) predictors of young adults’ patterns of nicotine/cannabis vaping in daily life, as well as consequences associated with vaping product use and co-use.

PI_NAMEs: DUNBAR, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: MAYNE, RACHEL G

PROJECT_TERMS: Adolescence;Adolescent;Advertising;Affect;Age;Alcohol consumption;Brain;California;Cannabis;Cohort Studies;combustible tobacco;daily functioning;Data;Development;Devices;Distal;Drug Delivery Systems;Drug usage;early adolescence;Ecological momentary assessment;Electronic Nicotine Delivery Systems;emerging adulthood;Exposure to;Frequencies;functional outcomes;Health;Health behavior;improved;Individual;innovation;intervention program;knowledge base;Life;Link;Location;Long-Term Effects;Longitudinal Surveys;marijuana legalization;marijuana use;marijuana vaping;Mental Health;Methods;Moods;Nicotine;nicotine use;novel;novel therapeutics;Occupational;Participant;Pattern;Persons;Pharmaceutical Preparations;physical symptom;Predictive Factor;Prevention;prospective;protective factors;psychosocial;Public Health;Recreation;recruit;Regulation;Reporting;Research;Risk;Risk Factors;Sampling;Sleep;smartphone application;social;substance use;Surveys;Time;time use;Tobacco;Tobacco use;tool;Toxin;vaping;vaping nicotine;Work;young adult

PROJECT_TITLE: Predictors and Consequences of Nicotine and Cannabis Vaping Co-use in Young Adults: A Longitudinal and EMA Analysis


ADMINISTERING_IC: OD

ARRA_FUNDED: N

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Data Science;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MISCELLANEOUS

ORG_FIPS: US

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PI_NAMEs: GOSWAMI, SUPARNA  (contact)

PROGRAM_OFFICER_NAME: JUEHNE, ANTHONY LEE

PROJECT_TERMS: Address;Award;chronic pain;Collaborations;Communities;Data;data access;data ecosystem;data management;diverse data;Ensure;Environment;expectation;FAIR principles;federated data;Funding;Future;healing;Helping to End Addiction Long-term;Knowledge;Opioid;opioid misuse;Overdose;programs;Public Health;Research;Research Personnel;Secure;Speed;stem;United States National Institutes of Health;Work

PROJECT_TITLE: A Strategy for Heal Federated Data Ecosystem


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Contraception/Reproduction;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Incarcerated pregnant women experience numerous sociodemographic and behavioral risks, which can compromise their health and the health of their infants. The proposed project is likely to have high public health impact by identifying key facilitators and barriers to implementing pregnancy and postpartum support programs in prisons, and documenting the outcomes among incarcerated women who receive these services. The project is relevant to the NICHD’s mission to ensure that every person is born healthy and that women suffer no harmful effects from reproductive processes.

PI_NAMEs: SHLAFER, REBECCA J. (contact)

PROGRAM_OFFICER_NAME: MITCHELL, MEGAN S

PROJECT_TERMS: Address;Admission activity;Age;Behavioral;Birth;Birth Weight;Breast Feeding;Caregivers;Cesarean section;Child;Childbirth;Communities;Companions;Complex;contextual factors;cost effectiveness;Data;Effectiveness;efficacy evaluation;Evaluation;experience;Exploration, Preparation, Implementation, and Sustainment;Family;Geography;Gestational Age;Goals;Health;health equity promotion;Health Professional;Health Services;Hospital Records;implementation barriers;implementation context;Imprisonment;improved;Infant;Intervention;Interview;Justice;Lactation;Length;Low income;Maternal Health;maternal outcome;Measurement;Methods;Minnesota;Mission;Modeling;National Institute of Child Health and Human Development;neonatal health;Neonatal Intensive Care Units;neonatal outcome;obstetrical complication;Outcome;Participant;Patient Self-Report;Persons;Pilot Projects;Population;postpartum care;Postpartum Depression;postpartum outcome;Postpartum Period;Postpartum Women;Pregnancy;Pregnancy Rate;pregnant;Pregnant Women;Premature Birth;Prenatal care;Prisons;Process;process evaluation;Program Description;programs;Public Health;Reduce health disparities;Reporting;reproductive;Reproductive Health;Reproductive Process;Research;Research Personnel;Risk;Sampling;satisfaction;Services;Site;Skin;Societies;sociodemographics;Structure;System;United States;Woman;Women's Group;Women's Health;Work

PROJECT_TITLE: Pregnancy and Postpartum Support Programs for Women in Prison: Maternal and Neonatal Outcomes

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Disability Research;Gene Therapy;Genetics;Hearing Loss;Neurosciences;Pediatric;Rehabilitation

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

ORG_STATE: MA

PHR: Project Narrative The proposal is to conduct IND-enabling studies by editing to treat two types of dominant genetic hearing loss DFNA41 and DFNA2. The goal is to develop a streamlined regulatory process with the FDA by the same delivery vehicle, editor and the delivery route with two gRNAs to target two types of deafness. The study may open the door to greatly speeding up the development of editing therapy in the clinic for over 20 dominant hearing loss.

PI_NAMEs: CHEN, ZHENG-YI  (contact)

PROGRAM_OFFICER_NAME: BROOKS, PJ

PROJECT_TERMS: adenovirus mediated delivery;Adult;Affect;Animal Model;Animals;Area;autosome;Behavior;Biodistribution;Biological Response Modifier Therapy;candidate identification;cell immortalization;Cell Line;Cell Survival;Cells;cellular transduction;Child;Clinic;Clinical Research;Clinical Trials;CMV promoter;Cochlear Implants;Communities;Complete Hearing Loss;Complex;congenital hearing loss;CRISPR therapeutics;Data;deaf;deafness;delivery vehicle;Dependovirus;design;Development;Disease;DNA Repair;DNA Sequence Alteration;Dominant Genetic Conditions;dominant genetic mutation;Dose;Ear;efficacy study;experience;Family suidae;FDA approved;Feedback;Foundations;gene replacement therapy;gene therapy;gene therapy clinical trial;Genes;Genetic Diseases;Genome;genome analysis;genome editing;Goals;Guide RNA;Hair Cells;Hearing;hearing impairment;hearing restoration;hereditary hearing loss;Human;Human Cell Line;Human Genetics;human model;in vivo;Inbred C3H Mice;Knowledge;Labyrinth;Macaca fascicularis;manufacture;Mediating;meetings;Minimally Invasive Surgical Procedures;mouse model;Mus;Mutant Strains Mice;Mutation;Natural History;Newborn Infant;nonhuman primate;novel therapeutics;off-target site;OTOF gene;Patients;Pharmacotherapy;Population;porcine model;preclinical study;Process;progressive hearing loss;Quality Control;RNA;Route;Safety;safety study;Sensory Hair;Speed;systemic toxicity;Technology;Testing;Therapeutic;Tissues;Toxic effect;transduction efficiency;Translations;Treatment Efficacy;Validation;vector;Vestibular epithelia;Vestibular inner ear;Viral Genome;Work

PROJECT_TITLE: AAV-mediated editing to treat human autosomal dominant hearing loss DFNA41 and DFNA2

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-S (70)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: Los Angeles

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: NARRATIVE Diversity in the ion channel composition of auditory and vestibular neurons is important for how they convey sensory information. The properties of ion channels are not fixed but can modulated by inputs from other cells to protect the neurons from damage. By understanding how this modulation works, our research will aid future therapies aimed at protecting the vulnerable neurons in the hearing and balance systems.

PI_NAMEs: KALLURI, RADHA  (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TITLE: The role of ion channels in shaping the function of inner ear neurons


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Immunotherapy;Infectious Diseases;Networking and Information Technology R&D (NITRD)

ORG_CITY: MUNICH

ORG_COUNTRY: GERMANY

ORG_FIPS: GM

ORG_NAME: TECHNICAL UNIVERSITY OF MUNICH

PI_NAMEs: BUSCH, DIRK  (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: 2019-nCoV;acute infection;Address;algorithm development;Algorithms;Antigen Presentation;Antigen Targeting;antigen-specific T cells;Antigens;Biochemical;cancer therapy;cancer type;Cells;chronic infection;cohort;Collection;combinatorial;Computer Models;Computing Methodologies;cross reactivity;Cytomegalovirus;cytotoxicity;Data;Data Set;design;Development;Engineering;Epitopes;Event;experience;extend lifespan;Face;Feedback;Formulation;Generations;Goals;Grant;Health;Hepatitis B Virus;HLA Antigens;Human;Human Herpesvirus 4;Human Papillomavirus;immune checkpoint blockade;Immune response;Immune system;Immunity;Immunology;Immunotherapy;improved;Individual;insight;Institution;interest;large datasets;large scale data;Libraries;Ligand Binding;Machine Learning;Malignant neoplasm of lung;Malignant Neoplasms;Maps;medical schools;Melanoma;method development;model development;Modeling;Molecular;mouse model;Mus;neoantigens;next generation;novel drug class;Oncogenic Viruses;Peptide/MHC Complex;Peptides;personalized medicine;Pharmaceutical Preparations;Probability;Productivity;Proteins;quantum;Receptor Signaling;Research;Research Personnel;response;Sampling;Signal Transduction;Simplexvirus;Source;Specificity;Stains;structural biology;Structure;System;T cell receptor repertoire sequencing;T cell response;T cell therapy;T memory cell;T-Cell Antigen Receptor Specificity;T-Cell Receptor;T-cell receptor repertoire;T-Cell Receptor Therapy;T-Lymphocyte;Technology;Testing;Therapeutic;therapy design;Toxic effect;Training;training data;tumor;Tumor Antigens;Uncertainty;Universities;Up-Regulation;Vaccination;Variant;Viral Antigens;Vision;Work

PROJECT_TITLE: MATCHMAKERS: Large-scale generation of TCR-pMHC pairs from naturally occurring sources.


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Down Syndrome;Infectious Diseases;Intellectual and Developmental Disabilities (IDD);Lung;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Recurrent respiratory infections are particularly common in individuals with Down syndrome and are  often life-threatening. Thus, it is important to understand the mechanisms by which the additional  genetic material in Down syndrome impacts lung immune activity and response to respiratory  pathogens; this would enable us develop/repurpose therapeutics that can protect people with Down  syndrome against pulmonary infections. Here,  we will apply organ-on-chip technology and develop a  physiologically relevant murine and human stem cell-derived model of lung-bone marrow axis to  delineate the impact of trisomy 21 on homeostatic physiology of lung, development of immune  dysregulation, and presence (if any) and mechanisms of hyperreactivity to inhaled influenza virus  infection.

PI_NAMEs: HAJIPOURAN BENAM, KAMBEZ  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: 3-Dimensional;Acute;Adult;Affect;airway epithelium;airway inflammation;Animals;Architecture;Benchmarking;Biochemical;Biological;Biology;Biomimetics;Biopsy;Blood;Blood Vessels;Body System;Bone Marrow;Cell Culture Techniques;Cell Differentiation process;Cell Separation;Cells;Chemicals;Chromosome 21;Chromosome abnormality;Clinical;Clinical Investigator;Collaborations;Data;Development;Devices;Down's Syndrome;Endothelial Cells;endothelial stem cell;Endothelium;Engineering;Environmental Exposure;Epithelial Cells;Exhibits;Exposure to;Future;Genetic;Genetic Engineering;Genetic Materials;Goals;Hematology;Hematopoietic;Hematopoietic stem cells;Homeostasis;Human;Human Chromosomes;human induced pluripotent stem cells;human stem cell-derived;human tissue;Hyperactivity;Hypersensitivity;Immune;immune activation;Immune response;Immunobiology;In Vitro;in vivo;Individual;induced pluripotent stem cell;Infection;Inflammation;influenza infection;influenzavirus;Inhalation;Innate Immune Response;innovation;intercellular communication;Interferons;International;Knowledge;Laboratories;Leukocytes;Life;Ligands;Link;Lung;Lung Diseases;Lung infections;lung injury;lung pathogen;manufacture;mechanical signal;Mediating;Mediator;Metabolic;Methods;microchip;Microfluidic Microchips;Microfluidics;microsystems;migration;model building;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Mutate;Myelogenous;Organ;Organ Model;organ on a chip;Pathology;Pathway interactions;Perfusion;Persons;Physiological;Physiology;Poly I-C;Protocols documentation;real-time images;reconstitution;Recurrence;Reporting;Resolution;Respiration Disorders;respiratory pathogen;Respiratory Tract Infections;response;Sampling;Signal Transduction;Smoke;stem cell biology;stem cell model;stem cells;Structure of parenchyma of lung;Syndrome;System;Technology;Therapeutic;Time;Tissue Sample;Tissues;TLR3 gene;translational impact;Translations;two-dimensional;Validation;Vascular Endothelium;Virion;Virus Diseases;Work

PROJECT_TITLE: Emulating Immune Dysregulation by Trisomy 21 in a Multi-Organ-on-a-Chip System

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-W(55)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: LOS ANGELES

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: RELEVANCE TO PUBLIC HEALTH Radiolabeled probes are a valuable tool for researchers to study new molecular insights into disease at the cellular, preclinical, or clinical levels, and ultimately can guide the development of new treatment approaches. Despite many advantages of these probes compared to fluorescent and bioluminescent probes, current approaches for developing these short-lived probes are very expensive and slow, hindering the transition of novel radiolabeled probes into routine use for research or clinical practice. This proposal aims to address this bottleneck via by developing a new technology that greatly accelerates the pace of discovery and process optimization for novel radiolabeled probes.

PI_NAMEs: CHATZIIOANNOU, ARION XENOFON;VAN DAM, ROBERT MICHAEL (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Acceleration;Address;Automation;Biological;Biological Assay;Clinical;clinical imaging;clinical practice;Consumption;cost;Development;Disease;Disease Progression;Exclusion;human error;Image;imaging study;improved;In Situ;In Vitro;in vivo;in vivo imaging;insight;Isotopes;Label;Manuals;Methods;Molecular;new technology;novel;novel therapeutic intervention;novel therapeutics;Positron-Emission Tomography;pre-clinical;pre-clinical research;preclinical imaging;pressure;Process;process optimization;Production;Property;Public Health;radiation detector;Radio;Radioactivity;Radiochemistry;Radioisotopes;Radiolabeled;Radiopharmaceuticals;radiotracer;Reaction;Reagent;Research;Research Personnel;Safety;Sampling;screening;Speed;System;targeted imaging;Technology;Time;Tissues;tool;Tracer

PROJECT_TITLE: Accelerating radiopharmaceutical discovery and development via high-throughput radiochemistry

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition

ORG_CITY: POMONA

ORG_DEPT: BIOLOGY

ORG_NAME: CALIFORNIA STATE POLY U POMONA

PHR: Project Narrative Not applicable. This is an application for Administrative Supplement, per Notice Number NOT-GM-24-021. Per PA-20-272, forms must be completed for the supplemental activities only and must not reflect funding or activities for previously awarded parent award. There is no change from information submitted and approved for the existing awarded Parent Grant R16GM145576.

PI_NAMEs: STEELE, ANDREW DAVID (contact)

PROGRAM_OFFICER_NAME: RICHARDS, CRYSTAL LYNETTE

PROJECT_TERMS: Adaptive Behaviors;Administrative Supplement;Anatomy;Animals;Award;Back;behavior observation;Behavioral;Biological Process;Brain;circadian;Corpus striatum structure;Dopamine;dopaminergic neuron;Eating;feeding;Food;Fright;Funding;Genetic;grasp;Light;Modernization;Mus;Nature;neural circuit;parent grant;parent project;Population;Rattus;Recording of previous events;Research;restoration;Societies;Stimulus;System;Temperature;Time;tool;Viral;Vision

PROJECT_TITLE: Administrative Supplement to Deciphering dopaminergic circuits required for food anticipatory activity in mice


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases;Zika Virus

ORG_CITY: FREDERICK

ORG_NAME: LEIDOS BIOMEDICAL RESEARCH, INC.

ORG_STATE: MD

PI_NAMEs: BEIGEL, JOHN  (contact)

PROJECT_TERMS: Emerging Communicable Diseases;Zika Virus

PROJECT_TITLE: IGF::OT::IGF ZIKA VIRUS AND OTHER EMERGING & REEMERGING INFECTIOUS DISEASES


NIH_SPENDING_CATS: Cancer;Climate-Related Exposures and Conditions;Prevention;Skin Cancer

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PI_NAMEs: LYUBIMOV, ALEXANDER  (contact)

PROJECT_TERMS: Actinic keratosis;Adverse effects;appropriate dose;Award;Bexarotene;Biological Assay;Biological Availability;Cancer Etiology;Canis familiaris;carcinogenesis;Cavia;Cells;Chemopreventive Agent;Clinical Research;Clinical Trials;Cold Therapy;Cytotoxic agent;Delayed Hypersensitivity;Dermal;Diclofenac;Dose;Drug Kinetics;Excision;Exhibits;Fluorouracil;Formulation;Gene Mutation;Government;Hepatocyte;High Pressure Liquid Chromatography;Human;Imiquimod;Immunocompromised Host;In Vitro;in vivo;Individual;inhibitor;Invasive Lesion;Irritants;Lesion;lipophilicity;Long-Term Effects;Macaca;Malignant - descriptor;Mammalian Cell;Maximum Tolerated Dose;medically necessary care;Metabolism;Methods;Miniature Swine;mouse model;Mus;Neutral Red;Operative Surgical Procedures;Oral;Oral Administration;Patients;PDPK1 gene;Penetration;PH Domain;pharmacodynamic biomarker;Phosphorylation;Phototoxicity;Plasma;premalignant;prevent;Prevention strategy;progression risk;Proto-Oncogene Proteins c-akt;Rattus;Recovery;Reporting;risk minimization;Skin;Skin Cancer;skin cancer prevention;Skin Carcinoma;skin irritation;skin organogenesis;small molecule;Squamous cell carcinoma;Topical application;Toxic effect;Toxicology;translation to humans;UVB carcinogenesis;Validation

PROJECT_TITLE: Award of Task Order 3 entitled "A Dual AKT/PDPK1 Inhibitor for Actinic Keratosis and Skin Cancer Prevention in Immunocompromised Individuals"


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Infectious Diseases

PI_NAMEs: OUTEN, JOHN  (contact)

PROJECT_TERMS: Address;Clinical Research;Clinical Trials;Cytomegalovirus;patient population;Phase IV Clinical Trials;programs;Selection for Treatments;Therapeutic;therapy development;Transplant Recipients;Virus Diseases

PROJECT_TITLE: Targeted Clinical Research Program to Address Selected Viral Infections


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases;West Nile Virus

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PI_NAMEs: BOWEN, RICHARD ARNOLD (contact)

PROJECT_TERMS: Alpha Virus;Arenavirus;Basic Science;Chikungunya virus;Contracts;Development;Evaluation;in vivo;infectious disease model;pathogenic virus;pathogens of pandemic potential;screening;West Nile virus;ZIKA

PROJECT_TITLE: Task A71: Comprehensive In Vivo Screening of Viral Pathogens of Pandemic Potential


NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: LAFAYETTE

ORG_NAME: UNIVERSITY OF LOUISIANA AT LAFAYETTE

ORG_STATE: LA

PI_NAMEs: VILLINGER, FRANCOIS  (contact)

PROJECT_TERMS: AIDS prevention;AIDS Vaccines;Breeding;CD8-Positive T-Lymphocytes;clinical efficacy;Development;Evaluation;evaluation/testing;flexibility;HIV;HIV vaccine;Housing;Immune response;immunogenicity;lipid nanoparticle;Macaca mulatta;Maintenance;Messenger RNA;Modality;Modeling;Mucosal Immune Responses;National Institute of Allergy and Infectious Disease;nonhuman primate;preclinical evaluation;preclinical study;prevent;Prevention Research;Prevention strategy;programs;research clinical testing;Research Personnel;Resources;Risk;T cell response;Testing;United States National Institutes of Health;vaccine efficacy;vaccine evaluation;Vaccine Research;Vaccines;Virus;Virus Diseases

PROJECT_TITLE: Evaluation of modified versus unmodified mRNAs in lipid nanoparticles to generate Anti-HIV CD8 T cell responses in rhesus macaques


ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PI_NAMEs: BOECKH, MICHAEL  (contact)

PROJECT_TERMS: Address;Adult;Advanced Development;Clinical Course of Disease;Clinical Research;Cytomegalovirus Infections;Diagnostics Research;Medical;patient population;Phase II Clinical Trials;programs;therapeutic development;Transplant Recipients;Virus Diseases


ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PI_NAMEs: HOOK, EDWARD  (contact)

PROJECT_TERMS: Bacterial Drug Resistance;Biological;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Cooperative Group;experience;gonorrhea vaccine;Human Resources;Infrastructure;Laboratories;Leadership;Phase II Clinical Trials;protocol development;sample collection;Sexually Transmitted Diseases;Training

PROJECT_TITLE: Task 12: Sexually Transmitted Infections Clinical Trials Group: Phase 2 Clinical Trial to Evaluate a Vaccine Candidate for Neisseria Gonorrhoeae


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Estrogen;Nutrition;Obesity;Prevention;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PI_NAMEs: TUROK, DAVID  (contact)

PROJECT_TERMS: Adherence;Age;Body mass index;Clinical;Clinical Trials;Clinical Trials Network;Contraceptive Agents;contraceptive efficacy;Contraceptive methods;Data;Drug Kinetics;Enrollment;Estrogens;Evaluation;Female Contraceptive Agents;Formulation;Free Will;Implant;Injectable;Injections;Intramuscular;Intrauterine Devices;Lactation;Levonorgestrel;Mission;National Institute of Child Health and Human Development;Non obese;Obesity;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pill;Population;Progestins;Public Health;Recording of previous events;recruit;Regimen;reproductive;Risk;Risk Reduction;Route;Safety;subcutaneous;Time;United States Food and Drug Administration;Utah;venous thromboembolism;Woman

PROJECT_TITLE: CCTN-PHARMACOKINETIC / PHARMACODYNAMIC EVALUATION OF LEVONORGESTREL BUTANOATE FOR FEMALE CONTRACEPTION - UTAH


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: SAN DIEGO

ORG_NAME: FORGE THERAPEUTICS, INC.

PI_NAMEs: TOMARAS, ANDREW  (contact)

PROJECT_TERMS: Advanced Development;antimicrobial resistant infection;Bacterial Drug Resistance;bacterial resistance;biodefense;candidate selection;Chemistry;Clinical assessments;Combating Antibiotic Resistant Bacteria;efficacy evaluation;Emerging Communicable Diseases;lead optimization;manufacture;pathogen;pre-clinical;product development;research and development;Research Support;safety assessment;Therapeutic;therapeutic candidate;therapeutic development

PROJECT_TITLE: Development of Therapeutic Products for Biodefense, Anti-Microbial Resistant (AMR) Infections and Emerging Infectious Diseases


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: DESSAU-ROSSLAU

ORG_NAME: IDT BIOLOGIKA GMBH

PI_NAMEs: TRUSHEIM, HEIDI  (contact)

PROJECT_TERMS: Adjuvant;Bacterial Drug Resistance;Biological Products;Clinical Research;Communicable Diseases;Contracts;Cyclic GMP;Development;Development Plans;enterotoxigenic Escherichia coli;manufacture;novel vaccines;pathogen;Phase;product development;Services;System;Toxoids;United States Food and Drug Administration;vaccine delivery;vaccine development;Vaccines

PROJECT_TITLE: Task V09: Development and Manufacture of Toxoid Fusion 3XSTAN12S-MNLTR192G/L211A and CFA/I/II/IV Master Banks


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: ALBANY

ORG_NAME: ALBANY MOLECULAR RESEARCH, INC.

ORG_STATE: NY

PI_NAMEs: SURMAN, MATT  (contact)

PROJECT_TERMS: absorption;Area;Award;Biological Assay;Chemistry;clinical pain;computational chemistry;Computer Assisted;Contractor;Contracts;design;drug discovery;Excretory function;Helping to End Addiction Long-term;In Vitro;Lead;Logistics;Metabolism;novel;novel therapeutics;Pain;Pain management;Parents;Performance;Prodrugs;Shipping;small molecule;Speed;Structure-Activity Relationship;therapeutically effective;Toxicology;United States National Institutes of Health

PROJECT_TITLE: HIT TO LEAD CHEMISTRY UNDER PERFORMANCE AREA 2 OF ID/IQ CONTRACT NO. HHSN271201800001I


NIH_SPENDING_CATS: Brain Disorders;Cannabinoid Research;Chronic Pain;Neurosciences;Pain Research;Therapeutic Cannabinoid Research

PI_NAMEs: BARNES, KEITH  (contact)

PROJECT_TERMS: absorption;Area;Biological Assay;Chemistry;clinical pain;CNR1 gene;Cognitive deficits;computational chemistry;Computer Assisted;Contractor;Contracts;Data;design;Development;direct application;drug discovery;Enzymes;Evaluation;Excretory function;Goals;Helping to End Addiction Long-term;In Vitro;inhibitor;Investigational Drugs;Investigational New Drug Application;Lead;lead optimization;Ligands;Logistics;Metabolic;Metabolism;National Institute of Neurological Disorders and Stroke;novel;novel therapeutics;Pain;Pain management;Performance;Performance at work;Pharmaceutical Chemistry;Phase;pre-clinical;Preparation;programs;Property;Research Personnel;scaffold;Seizures;Services;Shipping;small molecule;Speed;Structure-Activity Relationship;System;Testing;Therapeutic;therapeutically effective;Toxicology;United States National Institutes of Health


NIH_SPENDING_CATS: Cancer;Clinical Research;Data Science;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: DMITROVSKY, ETHAN  (contact)

PROJECT_TERMS: Acceleration;Adolescent and Young Adult;Age;anti-cancer research;Cancer Burden;cancer care;cancer diagnosis;Cancer Patient;Cause of Death;Childhood;Clinical;clinical care;Collaborations;Communities;Community Healthcare;Congresses;Continuity of Patient Care;Contracts;Data;Data Analyses;Data Collection;Data Commons;data ecosystem;data ingestion;data science infrastructure;data sharing;Databases;Diagnosis;diverse data;Ecosystem;Ensure;Federal Government;federated data;Funding;Goals;Grant;Health;improved;infancy;Institution;interoperability;Malignant Childhood Neoplasm;Malignant Neoplasms;Methods;Modeling;National Cancer Institute;Newly Diagnosed;Participant;prevent;programs;Recommendation;Registries;repository;Research;Research Personnel;Research Support;Resources;SEER Program;Services;sharing platform;tool;Training;treatment and outcome;United States;Visualization

PROJECT_TITLE: ENABLING NCI CLINICAL & RESEARCH DATA SHARING


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: LOGAN

ORG_NAME: UTAH STATE UNIVERSITY

PI_NAMEs: MORREY, JOHN  (contact)

PROJECT_TERMS: Alpha Virus;Basic Science;Chikungunya virus;Contracts;Development;Enterovirus;Evaluation;in vivo;infectious disease model;pathogenic virus;pathogens of pandemic potential;Rift Valley fever virus;screening;therapeutic development;Therapeutic Research;Virus;ZIKA


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: CHANTILLY

ORG_STATE: VA

PI_NAMEs: KENNEDY, LISA  (contact)

PROJECT_TERMS: Alzheimer's Disease;Clinical Research;Operations Research;Security;System

PROJECT_TITLE: NIA CLINICAL RESEARCH OPERATIONS MANAGEMENT SYSTEM (CROM) INDEPENDENT THIRD- PARTY SECURITY ASSESSMENT


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: KENSINGTON

ORG_NAME: ADVANCED BIOSCIENCE LABORATORIES, INC.

PI_NAMEs: VANCOTT, THOMAS  (contact)

PROJECT_TERMS: Adjuvant;Antigens;Chemistry;Clinical Trials;Contractor;Contracts;Data;Databases;Development;Documentation;efficacy study;Equipment and supply inventories;Formulation;Good Manufacturing Process;HIV vaccine;HIV-1;Human;immunogenicity;In Vitro;Investigational Drugs;Laboratories;Laboratory Animals;manufacture;Manufacturer;manufacturing process;Methods;National Institute of Allergy and Infectious Disease;Pamphlets;Phase;plasmid DNA;preclinical development;Preclinical Testing;Preventive vaccine;product development;Production;Proteins;Protocols documentation;prototype;quality assurance;Quality Control;Records;research clinical testing;Research Personnel;Testing;Toxicology;Vaccines;Viral Vector

PROJECT_TITLE: NIAID Preclinical Development Support: Adjuvants for HIV-1 Vaccines


ORG_CITY: EAST SETAUKET

PHR: This study is part of the NIH’s Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to understand the basis of pain and enhance clinical pain management.

PI_NAMEs: ARALDI, GIAN  (contact)

PROJECT_TERMS: Address;Chemical Structure;Chemistry;clinical pain;Clinical Research;Collaborations;Contractor;Data;design;Development;drug development;drug discovery;Electronic Mail;Feedback;Helping to End Addiction Long-term;Individual;Lead;lead optimization;member;Methodology;Pain;Pain management;Pharmaceutical Chemistry;Principal Investigator;Process;programs;Reporting;Research;Research Contracts;Role;Services;Speed;Strategic Planning;symposium;Telephone;Testing;United States National Institutes of Health;Visit

PROJECT_TITLE: MEDICINAL CHEMISTRY CONSULTING SERVICES


PI_NAMEs: JAMES, SCOTT  (contact)

PROJECT_TERMS: Advanced Development;Anti-viral Agents;Biological Assay;Cell Line;Contracts;Development;in vitro testing;Maintenance;screening panel;therapeutic development;Viral;Virus

PROJECT_TITLE: Task B21: Comprehensive Viral Screening Panel


NIH_SPENDING_CATS: Biotechnology;Neurosciences

PHR: The Drug Manufacturing and Formulation Program (DMFP), a component of the BPN, conducts the development and manufacture of dosage forms of small molecule drug candidates suitable for administration in preclinical efficacy studies, Investigational New Drug (IND) enabling studies, and clinical trials.

PROJECT_TERMS: Acceleration;analytical method;Clinical Trials;Contractor;Contracts;Data;Development;Documentation;Dosage Forms;drug candidate;drug development;drug distribution;early phase clinical trial;efficacy study;Formulation;good laboratory practice;Good Manufacturing Process;Grant;Investigational Drugs;Investigational New Drug Application;Label;manufacture;method development;novel therapeutics;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacologic Substance;preclinical efficacy;Preparation;Process;programs;Regulation;small molecule;support network;therapeutic development;United States Food and Drug Administration;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: IGF::OT::IGF TASK ORDER NO. 0001 - MEDICINAL CHEMISTRY SUPPORT PROGRAM FOR THERAPEUTIC DEVELOPMENT (MCSP


ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PI_NAMEs: SATTERTHWAITE, VIRGINIA  (contact)

PROJECT_TERMS: Academic support;Acceleration;Businesses;Charge;commercialization;Communities;Consultations;Data;Data Analyses;data ecosystem;Data Element;Databases;Decision Making;design;Development;Devices;Ecosystem;Education;Emerging Technologies;Environment;Equity;equity, diversity, and inclusion;Evaluation;evidence base;Funding;Goals;Health;Informatics;informatics infrastructure;Information Dissemination;Infrastructure;innovation;Maintenance;meetings;Mission;National Heart, Lung, and Blood Institute;novel diagnostics;programs;Recommendation;Resources;Services;skills;Small Business Innovation Research Grant;Small Business Technology Transfer Research;Strategic vision;Surveys;System;Therapeutic;tool;Translational Research;Translations;Visualization software;web page;Work;Writing

PROJECT_TITLE: NHLBI INNOVATION AND COMMERCIALIZATION ECOSYSTEM DATA SUPPORT, EVALUATION, AND ANALYSIS


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Contraception/Reproduction;Nutrition;Obesity;Patient Safety;Prevention;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PI_NAMEs: WESTHOFF, CAROLYN L (contact)

PROJECT_TERMS: Adherence;Age;Body mass index;Clinical;Clinical Practice Guideline;Clinical Trials;Clinical Trials Network;Colombia;Contraceptive Agents;contraceptive efficacy;Contraceptive methods;Contractor;Data;Development;Dose;Drug Kinetics;Enrollment;Estrogens;Evaluation;Female Contraceptive Agents;follow-up;Free Will;Goals;Good Clinical Practice;Government;Implant;Injectable;Injections;International;Intramuscular;Intrauterine Devices;Lactation;Levonorgestrel;Mission;Monitor;National Institute of Child Health and Human Development;Non obese;Obesity;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pill;Population;Progestins;protocol development;Protocols documentation;Public Health;Recording of previous events;Records;recruit;Regimen;Regulation;reproductive;Risk;Risk Reduction;Route;Safety;subcutaneous;symposium;Time;United States Food and Drug Administration;venous thromboembolism;Woman

PROJECT_TITLE: CCTN - PHARMACOKINETIC AND PHARMACODYNAMIC EVALUATION OF LEVONORGESTREL BUTANOATE FOR FEMALE CONTRACEPTION - COLOMBIA


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Physical Injury - Accidents and Adverse Effects

ORG_CITY: MENLO PARK

ORG_NAME: SRI INTERNATIONAL

PI_NAMEs: CHANG, POLLY YEE (contact)

PROJECT_TERMS: Animal Model;biodosimetry;Clinical;Clinical Research;Contracts;Development;Exposure to;Injury;medical countermeasure;Phase;Radiation exposure;Radiation Injuries;Radioisotopes;safety study;Sampling;Services;Testing

PROJECT_TITLE: DECORPORATION MCM PHASE 1 CLINICAL SAFETY STUDY


ORG_CITY: ROCKVILLE

ORG_NAME: BIOQUAL, INC.

PI_NAMEs: LEWIS, MARK  (contact)

PROJECT_TERMS: AIDS prevention;AIDS Vaccines;Antibodies;Antigens;Breeding;clinical efficacy;Development;Evaluation;evaluation/testing;flexibility;Goals;HIV;HIV vaccine;Housing;Immune response;immunogenicity;Macaca mulatta;Maintenance;Messenger RNA;Modality;Modeling;Mucosal Immune Responses;nanoparticle;National Institute of Allergy and Infectious Disease;neutralizing antibody;nonhuman primate;Pathway interactions;Polysaccharides;preclinical evaluation;preclinical study;prevent;Prevention Research;Prevention strategy;programs;research clinical testing;Research Personnel;Resources;Risk;Testing;United States National Institutes of Health;vaccine efficacy;vaccine evaluation;Vaccine Research;Vaccines;Virus;Virus Diseases

PROJECT_TITLE: Optimization of SOSIP Nanoparticle and mRNA Immunogens to Elicit V3 Glycan bNAbs in Rhesus Macaques


NIH_SPENDING_CATS: Aging

ORG_NAME: UNIVERSITY OF WASHINGTON

PI_NAMEs: LADIGES, WARREN  (contact)

PROJECT_TITLE: DEVELOPMENT AND MAINTENANCE OF AN AGED RODENT TISSUE BANKPERIOD OF PERFORMANCE: 3/15/2021 - 3/14/2022


ORG_CITY: LYME

ORG_STATE: CT

PHR: Subject matter expert support for developing therapies for neurological disorders

PI_NAMEs: MARTIN, WILLIAM  (contact)

PROJECT_TERMS: Address;assay development;Biochemical;Biological Assay;Biological Products;Biological Testing;Cells;Clinical;Clinical Research;Collaborations;Consultations;Contractor;design;Development;Development Plans;Electronic Mail;evaluation/testing;experimental study;in vitro Assay;Individual;Investigational Drugs;Lead;lead optimization;Logistics;manufacture;Measures;member;Nervous System Disorder;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pre-clinical;preclinical evaluation;Principal Investigator;product development;programs;Published Comment;Qualifying;Recommendation;Resources;Role;safety study;safety testing;Serum;Services;Strategic Planning;Telephone;therapeutic development;therapy development;timeline;Tissue Sample;Toxicology;United States National Institutes of Health;Validation;validation studies

PROJECT_TITLE: BIOACTIVITY ASSAY DEVELOPMENT CONSULTANT SUPPORT SERVICES


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Liver Disease;Racial and Ethnic Minority Health Research

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PI_NAMEs: KAPLAN, ROBERT  (contact)

PROJECT_TERMS: Acculturation;African;American;Area;Caribbean region;Chi-Square Tests;cohort;Data;Data Analyses;data management;Data Set;Development;Disease;European;Frequencies;Gene Frequency;Genetic;genetic association;Genetic Risk;genome-wide;Genomics;Goals;Hispanic;Hispanic Populations;Image;improved;Latino;Latino Population;Liver diseases;Liver Fibrosis;Magnetic Resonance Imaging;Manuscripts;Maps;Meta-Analysis;Metals;Minor;Modeling;non-alcoholic fatty liver disease;novel;Parents;Performance;Play;Preparation;Prevalence;Research Activity;Risk Factors;Role;statistics;Transaminases;Variant;Weight;Work

PROJECT_TITLE: HCHS-SOL AE FIELD CENTER DIVERSITY SUPPLEMENT FOR DR. TREJO


FUNDING_MECHANISM: SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: Ashburn

ORG_NAME: CARINA MEDICAL, LLC

PI_NAMEs: FENG, XUE  (contact)

PROJECT_TERMS: Aftercare;artificial intelligence model;Body Regions;cancer care;Classification;Clinical;clinical practice;Computer software;Consumption;Detection;Diagnostic;Disease;Effectiveness;Enlargement of lymph nodes;Evaluation;Foundations;Goals;Head and Neck Cancer;Image;improved;Institution;Interobserver Variability;Link;lymph nodes;Magnetic Resonance Imaging;Malignant Neoplasms;Measurement;Monitor;Multimodal Imaging;Nodal;Oncology;patient prognosis;Patients;Performance;Phase;Process;Safety;success;Time;treatment planning;usability;validation studies

PROJECT_TITLE: Multi-Modality Imaging-Based Quantitative Pre/During/Post-Treatment Lymph Node Monitoring in Cancers


ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PI_NAMEs: GABRIEL, STACY  (contact)

PROJECT_TERMS: advanced analytics;analytical tool;Biocompatible Materials;Clinical;Custom;Data;data integration;data quality;deep sequencing;Deposition;DNA Methylation;DNA Sequence Alteration;Ensure;exome;exome sequencing;experience;Fingerprint;Freezing;Genome;genome sequencing;Genomics;improved;Informatics;Malignant Neoplasms;Methods;Methylation;Molecular;Performance;Procedures;Proteomics;Public Domains;Qualifying;Quality Control;Research;Resolution;Resources;Sampling;Services;Site;Specimen;targeted sequencing;Validation;whole genome

PROJECT_TITLE: NCI'S GENOMIC CHARACTERIZATION CENTER IDIQ


PI_NAMEs: FOUTS, TIMOTHY  (contact)

PROJECT_TERMS: Adherence;AIDS prevention;Antibodies;Binding Sites;cGMP production;Clinical Research;Clinical Trials;Development;Epitopes;Future;Half-Life;HIV;HIV Antibodies;HIV envelope protein;HIV Vaccine Trials Network;improved;indicated prevention;Life Extension;Monoclonal Antibodies;Mutation;neutralizing antibody;next generation;Pharmaceutical Preparations;Prevention;Preventive measure;Probability;Regimen;stability testing

PROJECT_TITLE: Next Generation Development of Broadly Neutralizing HIV Antibodies for Prevention


FUNDING_MECHANISM: INTERAGENCY AGREEMENTS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures

ORG_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

PROJECT_TERMS: 3-Dimensional;Acetylation;Animal Model;biodosimeter;Differentiation Antigens;Dose;Exposure to;HMGB1 gene;human tissue;Immune;Ionizing radiation;Lysine;Modeling;mortality;Organ;Organoids;Plasma;Radiation;Radiation Toxicity;Rattus;Severities;Site;Surrogate Markers;Testing;Tissues;Translating;Whole-Body Irradiation;Work

PROJECT_TITLE: HMGB1 acetylation as differentiating marker of lethal versus sub-lethal radiation


NIH_SPENDING_CATS: Pediatric

ORG_CITY: CHICAGO

ORG_NAME: IIT RESEARCH INSTITUTE

PI_NAMEs: HORN, THOMAS  (contact)

PROJECT_TITLE: NON-CLINICAL SAFETY OF PTH-IA, INVERSE AGONIST, TO SUPPORT JANSEN METAPHYSEAL CHONDRODYSPLASIA (JMC) DISEASE.


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Physical Injury - Accidents and Adverse Effects

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PI_NAMEs: KUNUGI, KEITH  (contact)

PROJECT_TITLE: RNCP WIDE DOSIMETRY GUIDANCE & MONITORING OF SOURCES, AND IRRADIATION PROTOCOLS


NIH_SPENDING_CATS: Cancer

ORG_NAME: NATIONAL CANCER INSTITUTE

PROJECT_TITLE: Operations support for the NCI at Frederick Campus within the fence at Fort Detrick


NIH_SPENDING_CATS: Cancer;Natural Products

ORG_NAME: FISHER BIOSERVICES, INC.

PI_NAMEs: SCHROCK, RICHARD  (contact)

PROJECT_TERMS: anti-cancer;Biological;Chemicals;chemotherapeutic agent;Contracts;Databases;Development;Equipment and supply inventories;Evaluation;Extramural Activities;Goals;National Cancer Institute;Natural Products;Pharmaceutical Preparations;pre-clinical;Preclinical Drug Evaluation;Program Evaluation;repository;Research;Research Personnel;Sampling;Screening for cancer;Shipping;small molecule;small molecule therapeutics;Therapeutic Agents;Update

PROJECT_TITLE: REGISTRATION, STORAGE AND DISTRIBUTION OF CHEMICALS AND DRUGS FOR PRE-CLINICAL DISCOVERY, EVALUATION AND DEVELOPMENT


NIH_SPENDING_CATS: Complementary and Integrative Health;Contraception/Reproduction;Dietary Supplements;Infertility;Nutrition

PI_NAMEs: MANDACI, OGUZ  (contact)

PROJECT_TERMS: Affect;Clinical;Couples;DNA;embryo quality;Fertilization;Folic Acid;folic acid supplementation;implantation;improved;infertility treatment;Pregnancy Rate;Process;repository;Seminal fluid;Services;Specimen;Treatment outcome;Zinc;Zinc supplementation

PROJECT_TITLE: REPOSITORY SERVICES FOR FAZST SPECIMENS


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Estrogen;Nutrition;Obesity;Prevention;Women's Health Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PI_NAMEs: TEAL, STEPHANIE  (contact)

PROJECT_TERMS: Adherence;Age;Body mass index;Clinical;Clinical Trials;Clinical Trials Network;Contraceptive Agents;contraceptive efficacy;Contraceptive methods;Data;Drug Kinetics;Enrollment;Estrogens;Evaluation;Female Contraceptive Agents;Formulation;Free Will;Implant;Injectable;Injections;Intramuscular;Intrauterine Devices;Ions;Lactation;Levonorgestrel;Mission;National Institute of Child Health and Human Development;Non obese;Obesity;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pill;Population;Progestins;Public Health;Recording of previous events;recruit;Regimen;reproductive;Risk;Risk Reduction;Route;Safety;subcutaneous;Time;United States Food and Drug Administration;venous thromboembolism;Woman

PROJECT_TITLE: CCTN-PHARMACOKINETIC / PHARMACODYNAMIC EVALUATION OF LEVONORGESTREL BUTANOATE FOR FEMALE CONTRACEPTION - CU DENVER


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Prevention

ORG_CITY: TORRANCE

ORG_NAME: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER

PI_NAMEs: WANG, CHRISTINA  (contact)

PROJECT_TERMS: Admission activity;Androgens;Animals;Clinical Research;Clinical Trials;Contraceptive Agents;Contraceptive History;demographics;Dose;Drug Delivery Systems;Eligibility Determination;eligible participant;Enrollment;Fasting;first-in-human;Formulation;Gonadotropins;Informed Consent;Interview;Laboratories;Male Contraceptive Agents;man;Measures;Medical History;men;new chemical entity;Oral;overtreatment;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;phase I trial;Physical Examination;primary outcome;Procedures;Progestins;Protocols documentation;Randomized;recruit;Reproductive History;Schedule;screening;side effect;Site;Specific qualifier value;Specimen;sperm cell;Spermatogenesis;Testing;treatment duration;Visit;Writing

PROJECT_TITLE: CCTN - CONTRACEPTIVE CLINICAL TRIALS - SITES FOR MALE CONTRACEPTIVE STUDIES - DMAU


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: NEW TAIPEI CITY

ORG_COUNTRY: TAIWAN

ORG_FIPS: TW

ORG_NAME: PHARMACOLOGY DISCOVERY SERVICES TAIWAN, LTD.

PI_NAMEs: GALLACHER, ANTHONY  (contact)

PROJECT_TERMS: Bacterial Antibiotic Resistance;Bacterial Drug Resistance;bacterial resistance;Combating Antibiotic Resistant Bacteria;Contracts;Development;Escherichia coli;Evaluation;infectious disease model;mouse model;therapeutic development

PROJECT_TITLE: Task A82: Murine Models of UTI Caused by Antibiotic-Resistant Bacteria


NIH_SPENDING_CATS: Cancer;Data Science;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Adherence;biomedical informatics;Business Rules;Collaborations;Collection;Communities;Computer software;Contractor;curriculum development;data quality;data repository;data standards;Development;Feedback;improved;Information Technology;Infrastructure;Knowledge;member;Mentorship;Metadata;metadata standards;Methodology;Modeling;National Cancer Institute;next generation;programs;Reporting;repository;Semantics;Services;skill acquisition;Structure;Terminology;Training;United States National Institutes of Health;usability;Work

PROJECT_TITLE: Metadata Development, Curation, Harmonization and Program Support


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities

PROJECT_TERMS: biomedical informatics;Clinical Trials;Contracts;Funding;Information Technology;National Cancer Institute;programs;Reporting;Services

PROJECT_TITLE: Clinical Trials Reporting Porgram (CTRP) Program and Technical Support Services


PROJECT_TERMS: Address;Adolescent;Adolescent and Young Adult;anti-cancer research;Architecture;biomedical informatics;burden of illness;Child;Childhood;Clinical;Data;Data Commons;data ecosystem;data sharing;Data Sources;Development;Diagnosis;Ecosystem;Genome;Information Systems;Knowledge;Malignant Childhood Neoplasm;Malignant Neoplasms;Modernization;phenome;Process;programs;Research;success;System;United States

PROJECT_TITLE: Childhood Cancer Data Initiative Program Support


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: anti-cancer research;Architecture;biomedical informatics;Clinical;Clinical Research;Clinical Trials;Clinical Trials Database;Communities;Consultations;Contracts;Data;Data Commons;Databases;design;Development;Informatics;Information Technology;Maintenance;Malignant Neoplasms;Metadata;National Cancer Institute;operation;patient portal;precision medicine;programs;Reporting;Research;research and development;Semantics;Services;software development;System;Translational Research;Update;Vocabulary;web site;Work

PROJECT_TITLE: Biomedical Information Technology, Software Development, and Informatics Support


PROJECT_TERMS: anti-cancer research;Childhood;Clinical Research;Clinical Trials;cloud based;Collection;Communities;Data;Data Commons;data exchange;data harmonization;data integration;data platform;data quality;data registry;Data Sources;Databases;Division of Cancer Control and Population Sciences;effectiveness research;Environment;Goals;improved;Incidence;Informatics;Infrastructure;Malignant Childhood Neoplasm;Malignant Neoplasms;migration;Patient-Focused Outcomes;programs;Research;Resources;Services;tool

PROJECT_TITLE: Pediatric Cancer Data Commons Harmonization


NIH_SPENDING_CATS: Bioengineering;Cancer


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PI_NAMEs: SUNDBERG, MAJA  (contact)

PROJECT_TERMS: Advanced Development;Contracts;Development;Dose;Ebola Vaccines;efficacy testing;Filovirus;Formulation;immunogenicity;Individual;Lassa Fever;manufacture;Marburgvirus;nonhuman primate;research clinical testing;stability testing;Toxicology;vaccine candidate;Vaccines

PROJECT_TITLE: Advanced Development of a Multivalent Vaccine Candidate for Filovirus and Lassa Fever


NIH_SPENDING_CATS: Aging;Clinical Research

ORG_NAME: WESTAT, INC.

PI_NAMEs: BILLINGTON, CATHERINE  (contact)

PROJECT_TERMS: Aging;healthy aging;Home visitation;life span;Link;Neighborhoods;Participant

PROJECT_TITLE: HEALTHY AGING IN NEIGHBORHOODS OF DIVERSITY ACROSS THE LIFE SPAN HOME VISIT STUDY (HANDLS HVS): MAINTAINING VITAL LINKS TO AGING PARTICIPANTS


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PI_NAMEs: ORTIZ, JUSTIN  (contact)

PROJECT_TERMS: Clinical;Clinical Trials;design;Development;Ethics;Human;influenza virus vaccine;innovation;National Institute of Allergy and Infectious Disease;Phase;Phase II Clinical Trials;sound;System;universal influenza vaccine;vaccine candidate;vaccine trial;Vaccines

PROJECT_TITLE: Collaborative Influenza Vaccine Innovation Centers (CIVICs): Component C: Clinical Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PI_NAMEs: ROSS, TED  (contact)

PROJECT_TERMS: Adjuvant;Animal Model;Animals;anti-influenza;Area;Bioinformatics;Biological Assay;Biometry;Categories;Contractor;Contracts;Couples;Development;early phase clinical trial;Effectiveness;Elderly;Environment;Evaluation;Genetic;healthy volunteer;high risk;high risk population;Human;Human Volunteers;Immune;Immune response;Immunity;immunogenicity;Immunologics;Immunology;improved;Individual;Infection;influenza virus vaccine;innovation;Modeling;Mucous Membrane;National Institute of Allergy and Infectious Disease;next generation;novel;novel vaccines;obese person;Pathologic;Persons;Phase I/II Clinical Trial;Population;pre-clinical;pregnant;programs;Reagent;Recommendation;Recording of previous events;Research;Research Design;Research Personnel;Resources;response;Saint Jude Children's Research Hospital;seasonal influenza;skills;standard of care;Statistical Models;structural biology;Systems Biology;United States National Institutes of Health;universal influenza vaccine;universal vaccine;Universities;Vaccinated;Vaccination;vaccine candidate;Vaccine Design;vaccine development;Vaccine Research;vaccine response;vaccine strategy;Vaccines;virology;Vulnerable Populations;Work

PROJECT_TITLE: CIVIC: University of Georgia Center for Influenza Vaccine Research in High Risk Populations


NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PI_NAMEs: DENNY, THOMAS  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;AIDS Vaccines;assay development;Biological Assay;Contractor;Contracts;design;Ensure;HIV vaccine;HIV/SIV vaccine;Immunize;immunogenicity;Immunologics;Immunology;improved;Laboratories;Measurement;Measures;National Institute of Allergy and Infectious Disease;nonhuman primate;pre-clinical;preclinical study;prototype;Research Personnel;Simian Acquired Immunodeficiency Syndrome;simian human immunodeficiency virus;Site;SIV;SIV Vaccines;Standardization;Technology;United States National Institutes of Health;vaccine development;vaccine efficacy;vaccine evaluation;Vaccine Research;viral RNA;virology

PROJECT_TITLE: Nonhuman Primate Core Virology Laboratory for AIDS Vaccine Research and Development


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

PI_NAMEs: VEAZEY, RONALD S. (contact)

PROJECT_TERMS: AIDS prevention;AIDS Vaccines;Breeding;clinical efficacy;Development;env Gene Products;Evaluation;evaluation/testing;flexibility;HIV vaccine;HIV-1;Housing;Immune response;immunogenicity;Maintenance;Modality;Modeling;Mucosal Immune Responses;National Institute of Allergy and Infectious Disease;nonhuman primate;preclinical evaluation;preclinical study;prevent;Prevention Research;Prevention strategy;programs;recombinant viral vector;research clinical testing;Research Personnel;Resources;Risk;Testing;United States National Institutes of Health;vaccine delivery;vaccine efficacy;vaccine evaluation;Vaccine Research;Vaccines;vector vaccine;Virus;Virus Diseases

PROJECT_TITLE: Evaluation of the Immunogenicity and Efficacy of HIV-1 SOSIP Envelope Protein Vaccine Delivered with or without Recombinant Viral Vector Vaccines


NIH_SPENDING_CATS: Infectious Diseases;Prevention

ORG_CITY: WILMINGTON

ORG_NAME: PPD DEVELOPMENT LP

PI_NAMEs: PALLEJA, SANDRA  (contact)

PROJECT_TERMS: clinical trial implementation;Clinical Trials;Clinical Trials Unit;Communicable Diseases;Development;early phase clinical trial;Intervention;Investigation;National Institute of Allergy and Infectious Disease;New Agents;Prevention

PROJECT_TITLE: Task A: Early Phase Clinical Trial Units (EPCTU)


ORG_CITY: MC LEAN

ORG_NAME: BOOZ ALLEN HAMILTON

PI_NAMEs: KELLER, MICHAEL  (contact)

PROJECT_TERMS: Advanced Development;Archives;Area;biobank;Biocompatible Materials;Biological;Biological Specimen Banks;Clinical;Clinical Data;Clinical Research;Collection;Communities;Data;Data Analyses;data management;Data Pooling;data repository;Data Set;Diagnostic;diagnostic development;Disease;Distributed Databases;Ensure;Funding;genetic pedigree;Genotype;Home;Informatics;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;Performance;phenotypic data;Process;programs;Qualifying;Reporting;repository;Research Activity;Research Personnel;Resources;response;Sampling;Scientist;Services;Specimen;Statistical Data Interpretation;Testing;tool;United States Dept. of Health and Human Services;United States National Institutes of Health;usability;web site;Work

PROJECT_TITLE: Task Area A-Maintaining and Enhancing the NIDDK Central Repository Program


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PI_NAMEs: LUTSEY, PAMELA  (contact)

PROJECT_TERMS: Adult;African American;aged;Amyloid deposition;Ancillary Study;Area;arterial stiffness;Atherosclerosis;Atherosclerosis Risk in Communities;Atrial Fibrillation;Biochemical;Biological Assay;Blood specimen;Blood Vessels;Brain;Candidate Disease Gene;Cardiovascular Diseases;Case/Control Studies;caucasian American;Clinical;clinical development;clinical examination;clinical predictors;Cognition;cohort;Cohort Studies;Collaborations;Communities;Contracts;coronary artery calcification;Coronary heart disease;County;Cryopreservation;Data;Data Collection;data sharing;Death Rate;Dementia;Diabetes Mellitus;DNA;EFRAC;Electrocardiogram;Environmental Risk Factor;Event;follow-up;Fostering;Funding;Genetic;Genome Scan;Geographic Locations;Goals;Grant;Heart failure;Hospitalization;Injury;Investigation;Lymphocyte;member;middle age;Monitor;Myocardial Infarction;Natural History;novel;Participant;Policies;preservation;Process;Prospective, cohort study;Publications;Qualifying;recruit;Research Personnel;residence;Risk Factors;rural setting;Subgroup;suburb;Technology;trend;United States National Institutes of Health;Ventricular Dysfunction;Vital Status;Washington

PROJECT_TITLE: THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A


NIH_SPENDING_CATS: Hematology

ORG_CITY: CALVERTON

ORG_NAME: INFORMATION MANAGEMENT SERVICES, INC.

PI_NAMEs: GIFFEN, CAROL  (contact)

PROJECT_TERMS: Area;biobank;Biological Specimen Banks;blood resource;Cardiovascular system;Cell Therapy;Collection;Custom;Data;Data Collection;data repository;data resource;Data Set;Electronics;Epidemiology;Funding;Goals;Hematological Disease;Hematology;Infrastructure;Lung;Mission;National Heart, Lung, and Blood Institute;population based;Process;programs;Qualifying;Research;Research Personnel;Resources;Science;transfusion medicine;web site

PROJECT_TITLE: BIOLINCC PROGRAM: TASK AREA A - MAINTAINING AND ENHANCING THE BIOLINCC PROGRAM


ORG_STATE: MA

PHR: Subject matter expert support for the development of treatments for neurological disorders

PI_NAMEs: BENJAMIN, SUSAN  (contact)

PROJECT_TERMS: Address;analytical method;Antibodies;Antisense Oligonucleotides;Area;Biochemistry;Biological;Biological Assay;Biological Process;Biological Products;Biological Response Modifier Therapy;Cell Therapy;Cells;Chemistry;Clinical;Clinical Research;Collaborations;Complex;Contractor;Contracts;Data;Data Analyses;design;Development;Development Plans;Electronic Mail;Evaluation Studies;evaluation/testing;Feedback;Formulation;Government;Guidelines;improved;in silico;In Vitro;in vivo Model;Investigational Drugs;Investigational New Drug Application;Label;lead optimization;Leadership;Lentivirus;Liposomes;Logistics;manufacture;meetings;member;method development;Methodology;Methods;Modality;model development;nanoparticle;Needs Assessment;Nervous System Disorder;oligonucleotide therapeutics;Oligonucleotides;operation;Peptides;Performance;Persons;pharmacokinetics and pharmacodynamics;Pharmacology;Pharmacology and Toxicology;Pharmacology Study;Polymers;pre-clinical;preclinical evaluation;Preparation;Principal Investigator;Process;programs;protein purification;Protocols documentation;Published Comment;Rare Diseases;Recombinant Proteins;Recommendation;Regulation;Regulatory Affairs;Reporting;research and development;research clinical testing;Resources;Risk;Role;Running;safety study;safety testing;scale up;screening;Services;Small Interfering RNA;Specific qualifier value;Strategic Planning;symposium;Telephone;Testing;Therapeutic;therapeutic development;therapy development;timeline;Toxicology;United States National Institutes of Health;Viral;Viral Vector;Visit;Work

PROJECT_TITLE: BIOLOGICS SUBJECT MATTER EXPERT (SME) CONSULTING SERVICES


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Pain;Gene Therapy;Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

PHR: Development of non-addictive therapies for pain

PROJECT_TERMS: Address;analytical method;Antibodies;Antisense Oligonucleotides;Area;Biochemistry;Biological;Biological Assay;Biological Process;Biological Products;Biological Response Modifier Therapy;Cell Therapy;Cells;Chemistry;Clinical;clinical pain;Clinical Research;Collaborations;Complex;Contractor;Contracts;Data;Data Analyses;design;Development;Development Plans;Electronic Mail;Evaluation Studies;evaluation/testing;Feedback;Formulation;Government;Guidelines;Helping to End Addiction Long-term;improved;in silico;In Vitro;in vivo Model;Investigational Drugs;Investigational New Drug Application;Label;lead optimization;Leadership;Lentivirus;Liposomes;Logistics;manufacture;meetings;member;method development;Methodology;Methods;Modality;model development;nanoparticle;Needs Assessment;Nervous System Disorder;oligonucleotide therapeutics;Oligonucleotides;operation;Opiate Addiction;Opioid;opioid misuse;Pain;Pain management;Peptides;Performance;Persons;pharmacokinetics and pharmacodynamics;Pharmacology;Pharmacology and Toxicology;Pharmacology Study;Polymers;pre-clinical;preclinical evaluation;Preparation;Principal Investigator;Process;programs;protein purification;Protocols documentation;Public Health;Published Comment;Rare Diseases;Recombinant Proteins;Recommendation;Regulation;Regulatory Affairs;Reporting;Research;research and development;research clinical testing;Resources;Risk;Role;Running;safety study;safety testing;scale up;screening;Services;Small Interfering RNA;Specific qualifier value;Speed;Strategic Planning;symposium;Telephone;Testing;Therapeutic;therapeutic development;timeline;Toxicology;United States National Institutes of Health;Viral;Viral Vector;Visit;Work


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

PHR: Screening of potential therapeutic agents for epilepsy and related disorders.

PI_NAMEs: WILCOX, KAREN  (contact)

PROJECT_TERMS: Ancillary Study;Area;Biological Products;Contractor;Contracts;Devices;Disease;disease model;disorder prevention;Drug Kinetics;Epilepsy;Epileptogenesis;Evaluation;Event;Government;Intellectual Property;Intractable Epilepsy;Modification;National Institute of Neurological Disorders and Stroke;Natural Products;Performance;pharmacologic;pre-clinical;prevent;Property Rights;screening;screening program;small molecule;synthetic peptide;Therapeutic;Therapeutic Agents;Work

PROJECT_TITLE: SCREENING OF INVESTIGATIONAL THERAPEUTICS TO TREAT, MODIFY OR PREVENT EPILEPSY FOR THE NINDS EPILEPSY THERAPY SCREENING PROGRAM (ETSP)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: COLUMBUS

ORG_NAME: BATTELLE CENTERS/PUB HLTH RES & EVALUATN

ORG_STATE: OH

PI_NAMEs: RUDGE, THOMAS  (contact)

PROJECT_TERMS: Area;Biological;Biological Products;Bioterrorism;Clinical;Communicable Diseases;Contracts;Development;Ebola Vaccines;Ebola virus;Educational workshop;efficacy testing;Emerging Communicable Diseases;Evaluation;evaluation/testing;Feasibility Studies;Filovirus;immunogenicity;Immunology procedure;Investigational New Drug Application;Licensing;novel vaccines;Office of Administrative Management;product development;Prophylactic treatment;Qualifying;Reporting;Safety;Sampling;Services;Site Visit;Testing;testing services;Toxicology;Training;vaccine candidate;vaccine development;Vaccines;Validation

PROJECT_TITLE: Task X14: Evaluation of Filovirus Vaccines in a General Use Prophylaxis (GUP) Immunogenicity and Ebolavirus Challenge Studies to Identify Potential Correlates of Protection


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: DENNY, TOM  (contact)

PROJECT_TERMS: Address;Area;Contractor;Contracts;Development;Documentation;Equipment and supply inventories;flexibility;HIV;Investigational Drugs;Label;National Institute of Allergy and Infectious Disease;Phase;pre-clinical;Preclinical Testing;Process;product development;Production;programs;research and development;research clinical testing;Services;Shipping;vaccine development;Vaccines

PROJECT_TITLE: Preclinical and Translational Vaccine Development for HIV and Other Candidate Agents (PTVDS)


NIH_SPENDING_CATS: Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: ROCKVILLE

PI_NAMEs: MANDACI, OGUZ  (contact)

PROJECT_TERMS: Biopsy;Blood;Fetal Growth;Fetal Growth Retardation;Gestational Age;Membrane;National Institute of Child Health and Human Development;Non obese;Obesity;Observational Study;Placenta;pregnant;Pregnant Women;prospective;recruit;repository;Risk;Services;Specimen;Umbilical Cord Blood;Umbilical cord structure;Woman

PROJECT_TITLE: REPOSITORY SERVICES FOR NICHD FETAL GROWTH STUDY (NFGS) SPECIMENS


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Prevention

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PI_NAMEs: BREMNER, WILLIAM  (contact)

PROJECT_TERMS: Androgens;Animals;Clinical Trials;Contraceptive Agents;Dose;Effectiveness;first-in-human;Gonadotropins;Intramuscular;Male Contraceptive Agents;Measures;men;new chemical entity;novel therapeutics;Oral;overtreatment;Pharmaceutical Preparations;Phase I Clinical Trials;phase I trial;primary outcome;Progestins;side effect;sperm cell;Spermatogenesis;Testing;treatment duration

PROJECT_TITLE: CCTN - MALE CONTRACEPTIVE TRIAL DMAU-SEDDS STUDY


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PI_NAMEs: COUPER, DAVID  (contact)

PROJECT_TERMS: Adult;African American;aged;Amyloid deposition;Ancillary Study;Area;arterial stiffness;Atherosclerosis;Atherosclerosis Risk in Communities;Atrial Fibrillation;Biochemical;Biological Assay;Blood specimen;Blood Vessels;Brain;Candidate Disease Gene;Cardiovascular Diseases;Case/Control Studies;caucasian American;Clinical;clinical development;clinical examination;clinical predictors;Cognition;cohort;Cohort Studies;Collaborations;Communities;Contracts;coronary artery calcification;Coronary heart disease;County;Cryopreservation;Data;Data Collection;data sharing;Death Rate;Dementia;Diabetes Mellitus;DNA;EFRAC;Electrocardiogram;Environmental Risk Factor;Event;follow-up;Fostering;Funding;Genetic;Genome Scan;Geographic Locations;Goals;Grant;Heart failure;Hospitalization;Injury;Investigation;Lymphocyte;member;middle age;Monitor;Myocardial Infarction;Natural History;novel;operation;Participant;Policies;preservation;Process;Prospective, cohort study;Publications;Qualifying;recruit;Research Personnel;residence;Risk Factors;rural setting;Subgroup;suburb;Technology;trend;United States National Institutes of Health;Ventricular Dysfunction;Vital Status;Washington

PROJECT_TITLE: THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - COORDINATING CENTER - CORE STUDY OPERATIONS- TASK ORDER 01, TASK AREA A


ORG_CITY: JACKSON

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PI_NAMEs: MOSLEY, THOMAS  (contact)


NIH_SPENDING_CATS: Aging;Atherosclerosis;Biomedical Imaging;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Prevention;Social Determinants of Health

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PI_NAMEs: BERTONI, ALAIN  (contact)

PROJECT_TERMS: abdominal aorta;Address;African American;Age;aged;Aging;Air Pollution;Ancillary Study;Ankle;Aorta;Area;Atherosclerosis;Behavioral;Biological;brachial artery;Brain;cardiac magnetic resonance imaging;Cardiovascular Diseases;cardiovascular disorder risk;Cause of Death;Characteristics;Chinese;Clinical;clinical examination;cohort;Collaborations;Collection;Communities;Contracts;Coronary Arteriosclerosis;Correlation Studies;Data;Diabetes Mellitus;Disease;disease disparity;Disease Marker;Disease Outcome;Disease Progression;Dyslipidemias;Ethnic Origin;Event;Extramural Activities;follow-up;Fostering;Functional disorder;Funding;Genetic;genetic variant;Goals;Heart;Heart failure;heart function;Hispanic;Hypertension;improved;Incidence;indexing;insight;interest;Investigation;Kidney;Laboratories;Lung;Magnetic Resonance Imaging;Measurement;Measures;Mediating;men;mortality;Multi-Ethnic Study of Atherosclerosis;Myocardial;National Heart, Lung, and Blood Institute;Neighborhoods;Obesity;operation;Organ;Paper;Participant;Persons;Photography;Policies;Population;population based;Population Heterogeneity;predict clinical outcome;Prevalence;Process;psychologic;Publishing;Race;radial artery;recruit;Research Personnel;response;Retina;Risk Factors;Risk Marker;Sampling;sex;Smoking;Socioeconomic Factors;socioeconomics;Subgroup;tonometry;trend;ultrasound;United States;United States National Institutes of Health;vascular bed;Vascular Diseases;Woman;Writing;X-Ray Computed Tomography

PROJECT_TITLE: MESA TASK AREA A - CORE STUDY OPERATIONS FIELD CENTER (FC).


NIH_SPENDING_CATS: Cardiovascular;Chronic Obstructive Pulmonary Disease;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO STATE UNIVERSITY

ORG_STATE: CA

PI_NAMEs: TALAVERA, GREGORY  (contact)

PROJECT_TERMS: Adult;Ancillary Study;Area;Asthma;Cardiometabolic Disease;cardiovascular health;Cardiovascular system;Central American;Chicago;Chronic Obstructive Pulmonary Disease;Clinic;Clinical;cohort;Contracts;Cuban;Diabetes Mellitus;Disease;Dominican;Enrollment;epidemiology study;Event;follow-up;Funding;Funding Mechanisms;Future;Health;health care service utilization;Heart Diseases;High Prevalence;Hispanic;Hispanic Community Health Study/Study of Latinos;Hispanic Populations;Latino;Latino Population;Left Ventricular Hypertrophy;Lung;Lung Diseases;lung health;Measures;Medical;Mexican;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;National Institute on Minority Health and Health Disparities;Obesity;Onset of illness;operation;Participant;Phase;power analysis;Prevalence;protocol development;Puerto Rican;Risk;Risk Factors;Socioeconomic Factors;South American;Stroke;Training;United States

PROJECT_TITLE: HISPANIC COMMUNITY HEALTH STUDY (STUDY OF LATINOS (HCHS-SOL))FIELD CENTER


NIH_SPENDING_CATS: Atherosclerosis;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease

PI_NAMEs: PANKOW, JAMES   (contact)

PROJECT_TERMS: abdominal aorta;Address;aged;Ancillary Study;Ankle;Area;Behavioral;brachial artery;cardiac magnetic resonance imaging;Cardiovascular Diseases;Characteristics;Clinical;clinical examination;cohort;Collaborations;Collection;Contracts;Coronary Arteriosclerosis;Correlation Studies;Data;Data Analyses;Disease;Event;follow-up;Fostering;Functional disorder;Funding;genetic variant;Goals;indexing;interest;Investigation;Laboratories;Magnetic Resonance Imaging;Manuscripts;Measurement;Measures;Mediating;member;men;Multi-Ethnic Study of Atherosclerosis;Myocardial;National Heart, Lung, and Blood Institute;operation;Participant;Photography;Policies;population based;Population Heterogeneity;predict clinical outcome;Process;psychologic;radial artery;recruit;Research Personnel;response;Retina;Risk Factors;Risk Marker;Sampling;socioeconomics;Subgroup;tonometry;ultrasound;United States National Institutes of Health;Woman;Writing;X-Ray Computed Tomography

PROJECT_TITLE: Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin


NIH_SPENDING_CATS: Biotechnology;Neurosciences

ORG_CITY: KANSAS CITY

ORG_NAME: MIDWEST RESEARCH INSTITUTE

ORG_STATE: MO

PHR: accelerate the process of discovering and developing new drugs for neurological disorders

PI_NAMEs: CARTER, ALAN  (contact)

PROJECT_TERMS: Acceleration;analytical method;Clinical Trials;Contractor;Contracts;Data;Development;Documentation;Dosage Forms;drug candidate;drug development;drug distribution;early phase clinical trial;efficacy study;Formulation;good laboratory practice;Good Manufacturing Process;Grant;Investigational Drugs;Investigational New Drug Application;Label;manufacture;method development;Nervous System Disorder;novel therapeutics;Pharmaceutical Preparations;Pharmacologic Substance;preclinical efficacy;Preparation;Process;programs;Regulation;small molecule;support network;United States Food and Drug Administration;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: IGF::OT::IGF DRUG MANUFACTURING AND FORMULATION PROGRAM (DMFP) TASK ORDER #01:  PERFORMANCE ACTIVITY 1  TECHNICAL SUPPORT (1/15/15  1/14/16)


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: AMBLER

ORG_STATE: PA

PHR: Support development of novel therapies for neurological disorders

PI_NAMEs: LIN, JIUNN  (contact)

PROJECT_TERMS: Address;assay development;Chemistry;Clinical Research;Contractor;Data;Data Analyses;design;Development;drug development;drug discovery;Drug Kinetics;drug metabolism;Electronic Mail;Experimental Designs;Formulation;Investigational Drugs;Lead;lead optimization;Nervous System Disorder;novel therapeutics;programs;Protocols documentation;Recommendation;Reporting;Services;Telephone;United States National Institutes of Health

PROJECT_TITLE: SUBJECT MATTER EXPERT CONSULTANT FOR DRUG METABOLISM PHARMACOKINETICS [DMPK].


NIH_SPENDING_CATS: Aging

ORG_NAME: KAI RESEARCH, INC

ORG_STATE: MD

PI_NAMEs: YOU, HUIQING  (contact)

PROJECT_TERMS: Aging;Clinical Trials;Funding;operation

PROJECT_TITLE: THE PURPOSE IS TO CONTINUE OPERATION OF THE NIA CTOSC IN ORDER TO PROVIDE SUPPORT FOR THE MANAGEMENT, TRACKING, AND OVERSIGHT OF CLINICAL TRIALS FUNDED BY THE NIA.


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: LA JOLLA

ORG_NAME: LA JOLLA INSTITUTE FOR IMMUNOLOGY

PI_NAMEs: WILSON, STEPHEN  (contact)

PROJECT_TERMS: 3-Dimensional;Allergens;Alloantigen;analytical tool;Antibodies;Antigens;Area;Attention;Autoantigens;Communicable Diseases;Communities;Contractor;Contracts;Databases;Development;Epitope Mapping;Epitopes;Frequencies;HIV;Immune;improved;Link;Literature;Maps;Mission;Modeling;National Institute of Allergy and Infectious Disease;Online Systems;pathogen;prediction algorithm;programs;protein structure;Proteins;Publishing;relational database;Resources;Series;T-Lymphocyte Epitopes;tool;Toxin;Visualization;web site

PROJECT_TITLE: IMMUNE EPITOPE AND ANALYSIS PROGRAM: Infectious Diseases


NIH_SPENDING_CATS: Allergic Rhinitis (Hay Fever);Digestive Diseases;Food Allergies;Prevention

PROJECT_TERMS: Allergic Disease;Allergic rhinitis;analytical tool;Antibodies;Attention;Communities;Contractor;Contracts;Databases;Development;Epitope Mapping;Epitopes;Food Hypersensitivity;Immune;improved;Link;Literature;National Institute of Allergy and Infectious Disease;Online Systems;programs;protein structure;Publishing;relational database;Resources;Series;T-Lymphocyte Epitopes;tool;Visualization;web site

PROJECT_TITLE: IMMUNE EPITOPE AND ANALYSIS PROGRAM: Allergic Diseases including Food Allergy and Allergic Rhinitis


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Brain Disorders;Diabetes;Lupus;Multiple Sclerosis;Neurodegenerative;Neurosciences;Pediatric;Rheumatoid Arthritis

PROJECT_TERMS: analytical tool;Antibodies;Autoimmune Diseases;Communities;Contractor;Contracts;Databases;Development;Epitope Mapping;Epitopes;Immune;improved;Insulin-Dependent Diabetes Mellitus;Link;Literature;Lupus;Multiple Sclerosis;National Institute of Allergy and Infectious Disease;Online Systems;programs;protein structure;Publishing;relational database;Resources;Rheumatoid Arthritis;Series;Systemic Lupus Erythematosus;T-Lymphocyte Epitopes;tool;Visualization;web site

PROJECT_TITLE: IMMUNE EPITOPE AND ANALYSIS PROGRAM: Autoimmune diseases, including SLE, rheumatoid arthritis, type 1 diabetes, multiple sclerosis, and myathenia gravis


NIH_SPENDING_CATS: Organ Transplantation;Transplantation

PROJECT_TERMS: analytical tool;Antibodies;Attention;Cells;Communities;Contractor;Contracts;Databases;Development;Epitope Mapping;Epitopes;Immune;improved;Link;Literature;National Institute of Allergy and Infectious Disease;Online Systems;Organ;Organ Transplantation;programs;protein structure;Publishing;relational database;Resources;T-Lymphocyte Epitopes;Tissue Transplantation;Tissues;tool;Visualization;web site

PROJECT_TITLE: IMMUNE EPITOPE AND ANALYSIS PROGRAM: Transplantation of organs, tissues and cells


PI_NAMEs: SETTE, ALESSANDRO  (contact)

PROJECT_TERMS: analytical tool;Antibodies;Attention;Cells;Communicable Diseases;Communities;Contractor;Contracts;Databases;Development;Disease;Epitope Mapping;Epitopes;Immune;improved;Link;Literature;National Institute of Allergy and Infectious Disease;Online Systems;Organ;programs;protein structure;Publishing;relational database;Resources;T-Lymphocyte Epitopes;Tissue Transplantation;tool;Visualization;web site

PROJECT_TITLE: IMMUNE EPITOPE AND ANALYSIS PROGRAM (infectious diseases as result of other diseases)


ORG_CITY: SAN JOSE

ORG_NAME: CCS ASSOCIATES, INC.

PHR: Regulatory filing support for developing therapies for neurological disorders

PI_NAMEs: THOMAS, LYNN  (contact)

PROJECT_TERMS: Affect;Amendment;Clinical Protocols;Clinical Research;Ensure;Familiarity;Guidelines;Industry;Investigational New Drug Application;Medical;Nervous System Disorder;Pamphlets;Pharmaceutical Preparations;Preparation;Process;Quality Control;Regulatory Affairs;Research Personnel;Role;Services;therapy development;timeline;United States National Institutes of Health;Work;Writing

PROJECT_TITLE: REGULATORY AFFAIRS CONSULTING SUPPORT SERVICES


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Women's Health Research

ORG_NAME: WESTAT, INC.

PI_NAMEs: DRIVER, BARBARA  (contact)

PROJECT_TERMS: Adolescent;AIDS clinical trial group;Anti-Retroviral Agents;Charge;Child;Childhood;clinical center;clinical research site;Clinical Trials;co-infection;Collaborations;Conduct Clinical Trials;Diagnostic Procedure;Epidemiology;Evaluation;Funding;Grant;HIV;HIV Infections;HIV therapy;HIV/AIDS;Infant;Infrastructure;Institution;International;International Maternal Pediatric Adolescent AIDS Clinical Trials;Intervention;Investigational Therapies;Leadership;National Institute of Allergy and Infectious Disease;National Institute of Child Health and Human Development;Natural History;Opportunistic Infections;patient population;perinatal HIV;Pregnant Women;prevent;Prevention;Prevention strategy;Protocols documentation;Readiness;Research Personnel;Site;Symptoms;targeted treatment;Therapeutic Agents;transmission process;U-Series Cooperative Agreements;Vaccines;Vertical Disease Transmission

PROJECT_TITLE: CORE NICHD NETWORK CLINICAL SITE SUPPORT FOR IMPAACT RELATED STUDIES


NIH_SPENDING_CATS: Maternal Health;Nutrition;Women's Health Research

ORG_NAME: FISHER BIOSERVICES, INC.

PROJECT_TERMS: Biological Specimen Banks;clinical center;Eating;Equipment and supply inventories;Feces;Human;Maternal Health;microbiome;Monitor;National Institute of Child Health and Human Development;North Carolina;Plasma;Pregnancy;repository;Serum;Services;Specimen;System;Temperature;Umbilical Cord Blood;Urine

PROJECT_TITLE: HUMAN BIOSPECIMEN REPOSITORY - PREGNANCY EATING ATTRIBUTES STUDY


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PI_NAMEs: CORESH, JOSEF  (contact)

PROJECT_TERMS: Adult;African American;aged;Amyloid deposition;Ancillary Study;Area;arterial stiffness;Atherosclerosis;Atherosclerosis Risk in Communities;Atrial Fibrillation;Biochemical;Biological Assay;Blood specimen;Blood Vessels;Brain;Candidate Disease Gene;Cardiovascular Diseases;Case/Control Studies;caucasian American;Clinical;clinical development;clinical examination;clinical predictors;Cognition;cohort;Cohort Studies;Collaborations;Communities;Contracts;coronary artery calcification;Coronary heart disease;County;Cryopreservation;Data;Data Collection;data sharing;Death Rate;Dementia;Diabetes Mellitus;DNA;EFRAC;Electrocardiogram;Environmental Risk Factor;Event;follow-up;Fostering;Funding;Genetic;Genome Scan;Geographic Locations;Goals;Grant;Heart failure;Hospitalization;Injury;Investigation;Lymphocyte;member;middle age;Monitor;Myocardial Infarction;Natural History;novel;Participant;Policies;preservation;Process;Prospective, cohort study;Publications;Qualifying;recruit;Research Personnel;residence;Risk Factors;rural setting;Subgroup;suburb;Technology;trend;United States National Institutes of Health;Ventricular Dysfunction;Vital Status;Washington

PROJECT_TITLE: THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A


ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PI_NAMEs: ALLEN, NORRINA  (contact)

PROJECT_TITLE: TO EXERCISE OPTION PERIOD ONE (1) FOR TASK AREA A - MESA CORE OPERATIONS, FIELD CENTER.


NIH_SPENDING_CATS: American Indian or Alaska Native;Cardiovascular;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PI_NAMEs: STONER, JULIE  (contact)

PROJECT_TERMS: American Indians;Ancillary Study;Arizona;Biological Specimen Banks;Cardiovascular Diseases;cardiovascular disorder risk;clinical examination;clinical predictors;cohort;Cohort Studies;Collaborations;community engagement;data repository;Disease;epidemiology study;Etiology;Event;Family;Family Study;Fostering;Functional disorder;Funding;Heart;high risk;Investigation;Longitudinal, observational study;Native Americans;Natural History;Oklahoma;Participant;platform-independent;prospective;recruit;Research;Research Personnel;Risk Factors;Special Population;Testing;Training Support;tribal community;tribal Nation

PROJECT_TITLE: STRONG HEART STUDY (SHS)- COORDINATING CENTER (CC)- TASK ORDER 001


ORG_STATE: WA

PI_NAMEs: MCCLELLAND, ROBYN  (contact)

PROJECT_TERMS: abdominal aorta;Address;aged;Ancillary Study;Ankle;Area;Behavioral;brachial artery;cardiac magnetic resonance imaging;Cardiovascular Diseases;Characteristics;Clinical;clinical examination;cohort;Collaborations;Collection;Contracts;Coronary Arteriosclerosis;Correlation Studies;Data;Databases;Disease;Event;follow-up;Fostering;Functional disorder;Funding;genetic variant;Goals;indexing;interest;Laboratories;Magnetic Resonance Imaging;Maintenance;Measurement;Measures;Mediating;member;men;Multi-Ethnic Study of Atherosclerosis;Myocardial;National Heart, Lung, and Blood Institute;operation;Participant;Photography;Policies;population based;Population Heterogeneity;predict clinical outcome;Process;psychologic;radial artery;recruit;Research Personnel;response;Retina;Risk Factors;Risk Marker;Sampling;socioeconomics;Subgroup;tonometry;ultrasound;United States National Institutes of Health;Universities;Woman;Writing;X-Ray Computed Tomography

PROJECT_TITLE: Task Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp


ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

ORG_STATE: FL

PI_NAMEs: SCHNEIDERMAN, NEIL  (contact)

PROJECT_TITLE: HISPANIC COMMUNITY HEALTH STUDY (STUDY OF LATINOS) FIELD CENTER -  CORE STUDY OPERATIONS


ORG_CITY: WESTLAKE VILLAGE

PI_NAMEs: PEARSON, PAUL  (contact)

PROJECT_TERMS: Address;assay development;Chemistry;clinical pain;Clinical Research;Contractor;Data;Data Analyses;design;Development;drug development;drug discovery;Drug Kinetics;drug metabolism;Electronic Mail;Experimental Designs;Formulation;Helping to End Addiction Long-term;Investigational Drugs;Lead;lead optimization;Pain;Pain management;programs;Protocols documentation;Recommendation;Reporting;Services;Speed;Telephone;United States National Institutes of Health


PROJECT_TERMS: Address;assay development;Chemistry;Clinical Research;Contractor;Data;Data Analyses;design;Development;drug development;drug discovery;Drug Kinetics;drug metabolism;Electronic Mail;Experimental Designs;Formulation;Investigational Drugs;Lead;lead optimization;programs;Protocols documentation;Recommendation;Reporting;Services;Telephone;United States National Institutes of Health


NIH_SPENDING_CATS: Clinical Research;Neurosciences

ORG_CITY: SANBORNTON

ORG_STATE: NH

PI_NAMEs: JOHNSON, GRAHAM  (contact)

PROJECT_TERMS: Address;Chemical Structure;Chemistry;Clinical Research;Collaborations;Contractor;Data;design;Development;drug development;drug discovery;Electronic Mail;Feedback;Helping to End Addiction Long-term;Individual;Lead;lead optimization;member;Methodology;Pharmaceutical Chemistry;Principal Investigator;Process;programs;Reporting;Research;Research Contracts;Role;Services;Strategic Planning;symposium;Telephone;Testing;United States National Institutes of Health;Visit

PROJECT_TITLE: MEDICINAL CHEMISTRY CONSULTING SERVICES


ORG_CITY: MENLO PARK

ORG_NAME: SRI INTERNATIONAL

PI_NAMEs: GREEN, CAROL  (contact)

PROJECT_TERMS: Blood;Brain;Canis familiaris;Contractor;Development;Dose;drug development;drug discovery;Drug Kinetics;Human Resources;In Vitro;in vivo;in vivo evaluation;Lead;Mus;Nervous System Disorder;nonhuman primate;novel;Oryctolagus cuniculus;Performance;Pharmaceutical Chemistry;Process;programs;Rattus;Research Design;Rodent;Running;Series;Testing;Therapeutic;Tissues;United States National Institutes of Health

PROJECT_TITLE: SRI TO 13 - CONTINUOUS RODENT AND NON-RODENT PHARMACOKINETIC ASSESSMENTS


ORG_CITY: CARY

ORG_NAME: ALLUCENT GOVERNMENT SERVICES (US) LLC

PI_NAMEs: MARTIN, WILLIAM  (contact)

PROJECT_TITLE: SUBJECT MATTER EXPERT CONSULTANT FOR DRUG METABOLISM PHARMACOKINETICS [DMPK]


NIH_SPENDING_CATS: Immunization;Infectious Diseases;Prevention;Sexually Transmitted Infections;Vaccine Related

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PI_NAMEs: MADDOX, GRANT  (contact)

PROJECT_TERMS: Contracts;Cytomegalovirus;Development;Evaluation;guinea pig model;Herpes Simplex Infections;Herpesvirus Vaccines;infectious disease model;Mus;therapeutic development

PROJECT_TITLE: Task A78: Mouse and Guinea Pig Models for Cytomegalovirus and Herpes Simplex Vviruses


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: LOGAN

ORG_NAME: UTAH STATE UNIVERSITY

ORG_STATE: UT

PI_NAMEs: MORREY, JOHN  (contact)

PROJECT_TERMS: Animal Model;Contracts;Coronavirus Infections;COVID-19 therapeutics;Development;Evaluation;infectious disease model;therapeutic development;therapeutic evaluation

PROJECT_TITLE: Task A74: APP- High Throughput Evaluation of Therapeutics in Small Animal Models of Coronavirus Infection


NIH_SPENDING_CATS: Infectious Diseases;Prevention

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PI_NAMEs: NAGGIE, SUSANNA  (contact)

PROJECT_TERMS: clinical trial implementation;Clinical Trials;Clinical Trials Unit;Communicable Diseases;Development;early phase clinical trial;Intervention;Investigation;National Institute of Allergy and Infectious Disease;New Agents;Prevention

PROJECT_TITLE: Task A: Early Phase Clinical Trial Units (EPCTU)


NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PI_NAMEs: BLOUGH, BRUCE  (contact)

PROJECT_TERMS: Anti-Bacterial Agents;Antimicrobial Resistance;Chemistry;Combating Antibiotic Resistant Bacteria;Communities;drug discovery;Gram-Negative Bacteria;Libraries;rational design;therapeutic development

PROJECT_TITLE: Chemistry Center for Combatting Antibiotic-Resistant Bacteria (CC4CARB)


NIH_SPENDING_CATS: Aging;Biotechnology;Clinical Research;Congenital Structural Anomalies;Cost Effectiveness Research;Eye Disease and Disorders of Vision;Genetics;Health Services;Human Genome;Machine Learning and Artificial Intelligence;Macular Degeneration;Neurodegenerative;Neurosciences;Patient Safety;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ROCKVILLE

ORG_NAME: THE EMMES COMPANY, LLC

PI_NAMEs: MENEZES, SUPRIYA  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;active method;adaptive optics;age related;Age related macular degeneration;Anophthalmos;Area;Autologous Transplantation;Bilateral;biobank;Biocompatible Materials;Biological Markers;Case Series;Case/Control Studies;Cell Line;central retinal vein occlusion;Characteristics;Clinical;clinical epidemiology;Clinical Research;Clinical Trials;Cognition;Cold Therapy;Collection;Coloboma;Computer-Assisted Diagnosis;Contractor;Contracts;Cost Analysis;Cross-Sectional Studies;Dark Adaptation;Data;Data Analyses;data management;Databases;design;Development;Diabetic Retinopathy;Diagnosis;Disease;disease natural history;disorder of macula of retina;DNA Repository;Dose;Early treatment;economic evaluation;effectiveness analysis;Electrooculogram;Eligibility Determination;Epidemiology;epidemiology study;Esthesia;Evaluation;Evaluation Studies;exome;Extramural Activities;Exudative age-related macular degeneration;Eye;Eye diseases;Family;follow-up;Follow-Up Studies;Gene Transfer;Generations;Genetic;genome sequencing;Genotype;geographic atrophy;Healthcare;hemangioblastoma;Human;induced pluripotent stem cell;Inflammation;Inflammation Mediators;Inflammatory;Inherited;inhibitor;Injections;Intramural Research;Investigation;Longterm Follow-up;macula;Measures;Mediating;Medical Imaging;Medicare;metabolomics;Metformin;microbiome;Microglia;Microphthalmos;Minocycline;Molecular;Monitor;multimodality;Mutation;Natural History;Natural Language Processing;Observational Study;offspring;open label;Oral;Outcome;Outcome Measure;Outcomes Research;Participant;participant enrollment;Pathogenesis;Patient Monitoring;patient safety;Patients;Perception;Phase;phase I/IIa trial;Phenotype;Pilot Projects;preclinical study;prospective;Proteome;Quality of Life Assessment;Randomized;repository;Research;Resistance;Retina;Retinal Diseases;retinal imaging;retinal toxicity;Retinal Vein Occlusion;Retinitis Pigmentosa;retinyl palmitate;RPGR gene;Safety;safety study;Secondary to;Severities;sham-controlled study;Somatic Cell;Specific qualifier value;Stargardt's disease;Structure of retinal pigment epithelium;Supplementation;Surveys;Telangiectasis;Testing;Therapeutic immunosuppression;Type 7 Spinocerebellar Ataxia;Uveitis;Vascular Endothelial Growth Factors;Vertebrate Photoreceptors;virtual reality;Vision;Vision Disorders;Visual Motor Coordinations;Von Hippel-Lindau Syndrome;whole genome;Work;X-Linked Retinoschisis

PROJECT_TITLE: EO14042 DEVELOPMENT, STATISTICAL DESIGN, MONITORING AND COORDINATION OF VISION CLINICAL TRIALS AND EPIDEMIOLOGY RESEARCH


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Neurosciences;Prevention;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PI_NAMEs: ANDERSON, GARNET  (contact)

PROJECT_TERMS: Aging;Ancillary Study;Cardiovascular Diseases;Cardiovascular system;Classification;Clinical;cohort;Data;Discipline;epidemiology study;Event;follow-up;Funding;Goals;innovation;Knowledge;Life;Modification;National Heart, Lung, and Blood Institute;older women;Participant;platform-independent;power analysis;Prevention trial;Qualifying;Quality of life;Research;Research Personnel;resilience;Resources;sample collection;Women's Health

PROJECT_TITLE: THE PURPOSE OF THIS MODIFICATION IS TO DE-OBLIGATE NHLBI FUNDING FROM THE WOMEN'S HEALTH INITIATIVE (WHI) - CLINICAL COORDINATING CENTER (CCC).


ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PI_NAMEs: VITOLINS, MARA  (contact)

PROJECT_TERMS: Aging;Ancillary Study;Cardiovascular Diseases;Cardiovascular system;Classification;cohort;Data;Discipline;epidemiology study;Event;follow-up;Funding;Goals;innovation;Knowledge;Life;older women;Participant;platform-independent;power analysis;Prevention trial;Qualifying;Quality of life;Research;Research Personnel;resilience;Resources;sample collection;Women's Health

PROJECT_TITLE: WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC) - EXERCISING TASK AREAS A1 AND A2


NIH_SPENDING_CATS: Aging;Atherosclerosis;Biomedical Imaging;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Prevention;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PI_NAMEs: WATSON, KAROL  (contact)

PROJECT_TERMS: abdominal aorta;Address;African American;Age;aged;Aging;Air Pollution;Ancillary Study;Ankle;Aorta;Area;Atherosclerosis;Behavioral;Biological;brachial artery;Brain;cardiac magnetic resonance imaging;Cardiovascular Diseases;cardiovascular disorder risk;Cause of Death;Characteristics;Chinese;Clinical;clinical examination;cohort;Collaborations;Collection;Communities;Contracts;Coronary Arteriosclerosis;Correlation Studies;Data;Diabetes Mellitus;Disease;disease disparity;Disease Marker;Disease Outcome;Disease Progression;Dyslipidemias;Ethnic Origin;Event;Extramural Activities;follow-up;Fostering;Functional disorder;Funding;Genetic;genetic variant;Goals;Heart;Heart failure;heart function;Hispanic;Hypertension;improved;Incidence;indexing;insight;interest;Investigation;Kidney;Laboratories;Lung;Magnetic Resonance Imaging;Measurement;Measures;Mediating;men;mortality;Multi-Ethnic Study of Atherosclerosis;Myocardial;National Heart, Lung, and Blood Institute;Neighborhoods;Obesity;operation;Organ;Paper;Participant;Persons;Photography;Policies;Population;population based;Population Heterogeneity;predict clinical outcome;Prevalence;Process;psychologic;Publishing;Race;radial artery;recruit;Research Personnel;response;Retina;Risk Factors;Risk Marker;Sampling;sex;Smoking;Socioeconomic Factors;socioeconomics;Subgroup;tonometry;trend;ultrasound;United States;United States National Institutes of Health;vascular bed;Vascular Diseases;Woman;Writing;X-Ray Computed Tomography

PROJECT_TITLE: TASK AREA A - MESA CORE OPERATIONS, FIELD CENTER.


NIH_SPENDING_CATS: Cardiovascular;Chronic Obstructive Pulmonary Disease;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PI_NAMEs: KAPLAN, ROBERT  (contact)

PROJECT_TERMS: Adult;Ancillary Study;Area;Asthma;Cardiometabolic Disease;cardiovascular health;Cardiovascular system;Central American;Chicago;Chronic Obstructive Pulmonary Disease;Clinic;Clinical;cohort;Contracts;Cuban;Diabetes Mellitus;Disease;Dominican;Enrollment;epidemiology study;Event;follow-up;Funding;Funding Mechanisms;Future;Health;health care service utilization;Heart Diseases;High Prevalence;Hispanic;Hispanic Community Health Study/Study of Latinos;Hispanic Populations;Latino;Latino Population;Left Ventricular Hypertrophy;Lung;Lung Diseases;lung health;Measures;Medical;Mexican;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;National Institute on Minority Health and Health Disparities;Obesity;Onset of illness;operation;Participant;Phase;power analysis;Prevalence;protocol development;Puerto Rican;Risk;Risk Factors;Socioeconomic Factors;South American;Stroke;Training;United States

PROJECT_TITLE: HCHS-SOL - AE FIELD CENTER


NIH_SPENDING_CATS: American Indian or Alaska Native;Cardiovascular;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Prevention;Racial and Ethnic Minority Health Research;Rural Health

PROJECT_TERMS: American Indians;Ancillary Study;Arizona;Cardiovascular Diseases;cardiovascular disorder risk;Clinical;clinical examination;clinical predictors;cohort;Cohort Studies;Collaborations;Communities;community engagement;Disease;epidemiology study;Etiology;Event;Family;Family Study;follow-up;Fostering;Functional disorder;Funding;Heart;high risk;Investigation;Longitudinal, observational study;Morbidity - disease rate;mortality;Native Americans;Natural History;Oklahoma;Participant;platform-independent;prospective;recruit;Research Personnel;Risk Factors;Special Population;Training Support;tribal community;tribal leader;tribal Nation

PROJECT_TITLE: STRONG HEART STUDY (SHS)- FIELD CENTER (FC)- TASK ORDER 001


NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Immunization;Nanotechnology;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: NEW YORK

ORG_NAME: INTERNATIONAL AIDS VACCINE INITIATIVE

PI_NAMEs: HASSELL, THOMAS  (contact)

PROJECT_TERMS: Address;Contracts;Cyclic GMP;Development;Documentation;flexibility;HIV;HIV envelope protein;Investigational Drugs;manufacture;nanoparticle;National Institute of Allergy and Infectious Disease;Phase;pre-clinical;Preclinical Testing;Process;product development;Production;programs;research clinical testing;Services;stability testing;Vaccines

PROJECT_TITLE: cGMP Manufacture, Fill-Finish, Release, Analytical and Stability Testing and Stability Program of a Nanoparticle Based HIV Envelope Vaccine