NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE/RELEVANCE TO PUBLIC HEALTH The proposed study is designed to improve our understanding of the development of neural and behavioral cognitive mechanisms and social processes that comprise the transdiagnostic phenotype of heightened performance monitoring and overcontrol (HPM/OC) in relation to early markers of obsessive-compulsive disorder (OCD) and social anxiety disorder (SAD). Using cutting-edge and cost-effective electroencephalogram (EEG) techniques, we will investigate these relationships using three yearly assessments in a large sample of children spanning 4-9 years of age to assess developmental trajectories of cognitive Research Domain Criteria (RDoC) constructs in the emergence of the HPM/OC phenotype and in relation to relevant social contexts and psychiatric impairment. The overarching goal is a better understanding of the neurodevelopment of the HPM/OC phenotype in order to identify children at highest risk for multiple forms of psychiatric illness and to inform novel interventions that directly target the cognitive and social mechanisms of HPM/OC for optimal early intervention.

PI_NAMEs: GILBERT, KIRSTEN  (contact)

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: 6 year old;9 year old;Adolescence;Adult;Age;aged;Anorexia Nervosa;Attenuated;Behavioral;Behavioral Mechanisms;Child;Child Rearing;Childhood;Chronic;Cognitive;cognitive control;cognitive development;cognitive process;Communities;comorbidity;contextual factors;control theory;cost effective;Crystallization;Data;design;Development;Diagnostic;Dimensions;Disease;early childhood;Early identification;Early Intervention;Electroencephalography;Evaluation;Event-Related Potentials;Exhibits;experience;Frequencies;Functional disorder;Goals;Grain;high risk;Impairment;improved;indexing;insight;Intervention;Investigation;Knowledge;life span;Mental disorders;Mentored Patient-Oriented Research Career Development Award;Methods;Monitor;neural;neurobiological mechanism;Neurobiology;neurodevelopment;Neuronal Plasticity;novel;Obsessive-Compulsive Disorder;Onset of illness;Outcome;parental influence;peer;peer influence;Performance;Phenotype;Process;psychiatric symptom;Psychopathology;Public Health;recruit;Research;Research Domain Criteria;Resistance;response;Risk;Sampling;School-Age Population;Schools;severe psychiatric disorder;Severities;social;Social Anxiety Disorder;Social Development;Social Environment;social influence;Social Processes;Symptoms;Techniques;Time

PROJECT_TITLE: Neural and behavioral trajectories of the overcontrolled phenotype: Associations with development, social context and psychiatric symptoms in early childhood

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Opioid Misuse and Addiction;Opioids;Prevention;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: EMERGENCY MEDICINE

ORG_FIPS: US

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE Xylazine, an animal tranquilizer, has been increasingly detected in opioids throughout the eastern United States, Puerto Rico, and Canada. Xylazine may increase the risk of opioid-related overdose or death and is associated with the development of severe infected ulcerating skin lesions in both injection and non-injection sites. This project is expected to significantly contribute to informing optimal harm reduction interventions that can be rapidly implemented to mitigate harms associated with xylazine adulteration.

PI_NAMEs: REED, MEGAN  (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: acceptability and feasibility;Address;Adrenergic Agonists;adverse outcome;Amputation;Animals;Bradycardia;Canada;Care given by nurses;Central Nervous System;Cessation of life;Cities;Communities;Country;Data;design;Development;Dopamine;Drug abuse;drug market;evidence base;experience;Feedback;Fentanyl;Goals;Harm Reduction;Health;Heroin;Hospitals;Hypotension;Injections;Intervention;intervention refinement;Knowledge;Link;Marketing;Massachusetts;Muscle relaxation phase;Neurotransmitters;Norepinephrine;Opioid;opioid overdose;opioid user;Outcome;overdose death;Pain;patient oriented;Peripheral;person centered;Persons;Pharmaceutical Preparations;Philadelphia;Positioning Attribute;prevent;Public Health;Puerto Rico;Research;Research Personnel;Research Support;response;Risk;rural area;Sampling;screening;Sedation procedure;Services;sexual assault;Site;skin lesion;Stimulus;symposium;Testing;therapy design;Time;Toxicology;Tranquilizing Agents;Translating;United States;Vasoconstrictor Agents;Ventilatory Depression;webinar;Work;wound care;Xylazine

PROJECT_TITLE: Community-informed approaches to the escalating presence of xylazine in opioids


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome;Nanotechnology;Prevention

ORG_CITY: CHAPEL HILL

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE Periodontal diseases are disorders associated with non-resolving inflammation affected by, and a risk factor for, other systemic diseases including diabetes. Effective treatments for periodontal disorders are needed to preserve both oral and systemic health. We aim to synthesize nitric-oxide, hyaluronic acid-based materials for localized oral delivery; delineate the mechanisms modulating microbial dysbiosis, immune dysfunction and tissue-stasis; and, test therapeutic efficacy for inhibiting periodontal disease progression.

PI_NAMEs: SCHOENFISCH, MARK H (contact);WALLET, SHANNON MARGARET

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Affect;Anti-Bacterial Agents;Anti-Inflammatory Agents;antimicrobial;Autoimmunity;Biopolymers;Calculi;Cardiovascular Diseases;Cell Culture System;Cells;Chronic;Clinical;Complex;cytotoxicity;Data;dental biofilm;Development;Diabetes Mellitus;Disease;Disease Progression;Dose;Drug Delivery Systems;dysbiosis;effective therapy;efficacy evaluation;Epithelial Cells;Excision;Failure;Fibroblasts;Formulation;Frequencies;Gingiva;Glycosaminoglycans;Goals;healing;Health;Homeostasis;Human;human model;Hyaluronic Acid;immune function;Immune system;Immune System Diseases;Immunity;immunoregulation;improved;in vivo;in vivo evaluation;Individual;Inflammation;innate immune function;Integration Host Factors;Intervention;Kinetics;Ligature;macromolecule;Macrophage;Mammalian Cell;Mechanics;microbial;Microbial Biofilms;microbial homeostasis;Modeling;mouse model;Mucous Membrane;nanomaterials;nanoparticle;neutrophil;Nitric Oxide;Nitric Oxide Donors;Oral;oral cavity epithelium;Osteoclasts;patient population;Periodontal Diseases;Periodontal Pocket;Periodontitis;perpetrators;Phase;Play;preservation;prevent;Primary Cell Cultures;programs;Property;Refractory;Research;Resolution;Risk Factors;Role;Series;Structure;subgingival biofilm;Surface;System;Systemic disease;systemic inflammatory response;Systems Biology;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;Tissue Model;Tissues;Toxic effect;translational therapeutics;Treatment Efficacy;wound healing

PROJECT_TITLE: Nitric oxide-releasing hyaluronic acid therapeutics for treating periodontal disease

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ADMINISTERING_IC: NS

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Gene Therapy;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: BLACKSBURG

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE Chimeric Antigen Receptor (CAR) T-cells are cell-based therapies that are being investigated as a novel immunotherapy treatment for several forms of cancer including glioblastoma. We propose to combine clinical imaging techniques to measure interstitial fluid flow with predictive modeling with the goal of characterizing barriers to optimal CAR T-cell administration and to identify imaging biomarkers for evaluation and prediction of clinical response to CAR T-cell therapy. Thus, we will be able to determine the best strategy for treating patients with this innovative and promising clinical treatment.

PI_NAMEs: BROWN, CHRISTINE ;MUNSON, JENNIFER M (contact);ROCKNE, RUSSELL CHRISTIAN

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Address;Adoptive Transfer;biomarker evaluation;Brain;Brain Neoplasms;brain tissue;CAR T cell therapy;Cell Communication;cell motility;Cell Therapy;cell type;Cells;Central Nervous System;Cerebrospinal Fluid;chimeric antigen receptor;chimeric antigen receptor T cells;Cities;Clinical;clinical biomarkers;clinical imaging;clinical predictors;clinical translation;Clinical Treatment;Clinical Trials Design;clinically relevant;Computer Models;Data;Dendritic Cells;Disease;draining lymph node;early phase clinical trial;effective therapy;Effectiveness;ERBB2 gene;Exposure to;Extracellular Matrix;Extracellular Space;fluid flow;Future;Glioblastoma;Goals;imaging biomarker;Imaging Techniques;Immune;Immune response;Immunotherapy;improved;In Vitro;in vivo;Infection;Infiltration;Infusion procedures;Injury;innovation;Intercellular Fluid;Invaded;Knowledge;Link;Liquid substance;Location;Magnetic Resonance Imaging;Malignant Neoplasms;mathematical model;Measures;Mediating;migration;Modeling;Monitor;multidisciplinary;Mus;neoplastic cell;Neuroglia;non-invasive imaging;novel;Patients;Pattern;Peripheral;potential biomarker;predictive marker;predictive modeling;programs;receptor;response;response biomarker;Role;Route;Safety;shear stress;Solid Neoplasm;Structure;Surgically-Created Resection Cavity;T-Lymphocyte;Techniques;Therapeutic;Therapeutic Effect;Therapeutic Intervention;Tissue Engineering;Tissues;trafficking;Translating;Treatment Efficacy;treatment optimization;tumor;tumor growth;tumor microenvironment;tumor progression;Work

PROJECT_TITLE: The impact of interstitial fluid flow on CAR T cell trafficking, distribution, and efficacy

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

ORG_STATE: CA

PHR: PROJECT NARRATIVE Disparities in access to care and inadequate insurance contribute to the disparities in behavioral health diagnoses and treatment for racial and ethnic minority children with special health care needs (CSHCN). Our study will examine the extent to which automatic enrollment in Medicaid via Supplemental Security Income (SSI) reduces these disparities. Using two complementary analytic sources with large-scale survey and administrative data, our findings will provide critical insights about how reducing administrative burden may improve health equity for disadvantaged and underserved CSHCN with behavioral health needs.

PI_NAMEs: RENNANE, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: access disparities;Address;Affect;Attention deficit hyperactivity disorder;autism spectrum disorder;behavioral health;beneficiary;Black Populations;Black race;care coordination;Caring;Characteristics;Child;Child Mental Health;Child Welfare;Data;demographics;Desire for food;Diagnosis;Disadvantaged;Disparity;Disparity population;disparity reduction;Documentation;Early identification;Early Intervention;Early treatment;Eligibility Determination;Enrollment;ethnic disparity;ethnic minority;Ethnic Origin;experience;experimental study;falls;Family;Health;Health Benefit;health care availability;health care service utilization;health disparity;health equity;Health Insurance;health service use;Health Services;Health Services Accessibility;Health Status;Healthcare;Hispanic;Home;Hospitalization;improved;insight;Insurance;Insurance Coverage;insurance plan;Intervention;Latino;Latino Population;Life;Life Cycle Stages;Long-Term Effects;Low income;lower income families;Medicaid;Medical;medically underserved;Mental Depression;Mental Health;Mental Health Services;minority children;Natural experiment;Outcome;Policies;poor health outcome;Population;Privatization;Process;programs;Race;racial disparity;racial minority;Reduce health disparities;Reporting;Research;Risk;Role;Running;Services;Source;Special needs;Supplemental Security Income;Surveys;Time;Underinsured;Underserved Population;Variant;Work

PROJECT_TITLE: Reducing Behavioral Health Disparities among Children with Special Needs: The Role of Medicaid Automatic Enrollment

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Gene Therapy;Genetics;Hearing Loss;Rehabilitation;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Hearing loss and balance disorders are significant health problems worldwide, with many disorders having genetic causes. The research proposed in this study will utilize DNA and tissue samples from individuals with genetic hearing loss to develop protocols and methods for gene therapies. Mice engineered with the same pathogenic variants resulting in hearing and balance problems will provide the means for testing our innovative gene therapy approaches for genetic hearing loss.

PI_NAMEs: MORTON, CYNTHIA CASSON (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: Adult;Age;Alleles;Auditory system;Biological;Biology;Boston;Categories;cell type;Characteristics;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;deafness;Dermal;design;design and construction;design verification;Development;Disease;disease model;DNA;Early Intervention;early onset;Engineering;Enzymes;equilibration disorder;Equilibrium;Evaluation;experimental study;Fibroblasts;Functional disorder;gain of function;gain of function mutation;gene correction;Gene Delivery;gene discovery;gene editing technology;Gene Targeting;gene therapy;gene-editing approach;Genes;Genetic;genetic approach;Genetic Transcription;GJB2 gene;Goals;Guide RNA;Health;Hearing;hearing impairment;hereditary hearing loss;Heterozygote;Histologic;Human;In Vitro;in vivo;Individual;induced pluripotent stem cell;Injections;inner ear development;innovation;insertion/deletion mutation;interest;Knock-in;Knock-in Mouse;Laboratories;Labyrinth;Mediating;Mesenchymal;Messenger RNA;Methods;Modeling;mouse model;mRNA Expression;Mus;mutant;Mutation;next generation sequencing;Nonsense-Mediated Decay;novel strategies;nucleofection;Organism;Organoids;Pathogenicity;Pathology;Patients;Pediatric Hospitals;Phenotype;Plasmids;Pluripotent Stem Cells;Population;postnatal;preservation;prevent;Procedures;progressive hearing loss;Proteins;Protocols documentation;Reagent;Research;Resources;round window;Safety;safety assessment;Sensorineural Hearing Loss;Severities;Site;Skin;skin biopsy;Specificity;success;System;Temporal bone structure;Testing;Therapeutic;Therapeutic Intervention;Time;Tissue Sample;Tissues;tool development;Transcript;transduction efficiency;Transfection;translational goal;Treatment Efficacy;Variant;vector;Vestibular dysfunction;vestibular system

PROJECT_TITLE: Genetic Approach to Therapy for DFNA9

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Epilepsy;Neurodegenerative;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The goal of this study is to characterize the relationship between late-onset epilepsy (epilepsy starting at age 60 or later, in the absence of stroke or other identified cause) with cognitive changes and AD biomarkers, hypothesizing that patients with late-onset epilepsy are at risk for cognitive decline and may have preexisting neuropathology. The results will be used to identify patients at risk for cognitive impairment who may benefit from clinical trials, and will contribute to scientific knowledge about the nature of late-onset epilepsy and its implication for future cognitive changes.

PI_NAMEs: JOHNSON, EMILY  (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Adult;Age;aged;aggressive therapy;Aging;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Amyloid deposition;Apolipoproteins;Appointment;Atherosclerosis Risk in Communities;Biological Markers;Biometry;brain magnetic resonance imaging;career development;Clinical;Clinical Trials;Code;Cognition;Cognitive;cognitive change;cognitive performance;cognitive testing;cohort;Cohort Studies;Data;Dementia;Development;Development Plans;Diagnosis;Early Intervention;Elderly;Electroencephalography;Epidemiology;Epilepsy;epileptiform;Etiology;Functional disorder;Funding;Future;Genotype;Goals;Grant;Hour;Impaired cognition;Incidence;Individual;innovation;Intervention;Knowledge;Life;Light;Longitudinal cohort;Manuscripts;Measures;meetings;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Monitor;Nature;Nerve Degeneration;Neurodegenerative Disorders;neurofilament;Neurologist;Neurology;neuropathology;neurophysiology;older adult;Outcomes Research;Participant;Pathologic;Pathology;Patients;Persons;Phenotype;Plasma;Population;prevent;prospective;Public Health Schools;Recording of previous events;recruit;Research;research clinical testing;Research Personnel;Risk;Seizures;skill acquisition;skills;Stroke;supportive environment;symposium;tau Proteins;tau-1;Testing;Time;Training;Visit;Work

PROJECT_TITLE: Late-onset Epilepsy and Cognition

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: LEXINGTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative  Brain arteriolosclerosis (B-ASC), the pathologic thickening of small blood vessels in the brain, is a common contributor of cognitive decline in aged individuals, but the genetic risk factors are poorly understood. This project will identify multi-omic risk factors of B-ASC and identify the shared genetic risk between B-ASC and associated neuropathologies. Findings will provide mechanistic insight into B-ASC and identify potential therapeutic targets.

PI_NAMEs: SHADE, LINCOLN  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Adult;Age;aged;Aging;aging population;Alzheimer's Disease;Architecture;arteriole;Autopsy;Bioinformatics;Biological;Biological Assay;Brain;brain arteriolosclerosis;Brain Pathology;career;case control;cell type;Cells;Cerebrovascular Disorders;Cerebrovascular system;Cessation of life;Chromosomes;Clinical;Clinical Research;clinical risk;Cognitive;cohort;comorbidity;Complex;Data;Data Set;Dementia;design;Development;Diabetes Mellitus;Disease;DNA Methylation;endophenotype;Epidemiologist;experience;Fellowship;Functional disorder;functional genomics;Gene Expression;Generations;Genetic;genetic association;Genetic Risk;genetic risk factor;Genetic study;genome wide association study;genome-wide;Genomics;Genotype;hippocampal sclerosis;human old age (65+);Hypertension;Impaired cognition;insight;Internet;Knowledge;Memory;Mentors;Methods;Methylation;Modality;Molecular;molecular phenotype;multidisciplinary;Multiomic Data;multiple omics;neuroimaging;neuropathology;new therapeutic target;Outcome;Participant;Pathologic;Pathology;Pathway interactions;Phenotype;Pilot Projects;Prefrontal Cortex;Preparation;Process;recruit;religious order study;Research;Research Personnel;Resources;Risk;Risk Factors;risk sharing;risk variant;Sampling;skills;Source;Statistical Methods;Testing;therapeutic target;Training Programs;trait;Translating;translational genomics;United States National Institutes of Health;Update

PROJECT_TITLE: Elucidating Shared Risk of Brain Arteriolosclerosis and Related Pathologies with Multiple 'omics Modalities


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Pain Research;Palliative Care;Social Determinants of Health

ORG_CITY: BIRMINGHAM

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE For the 6.2 million U.S. adults living with heart failure (HF), the burden of poor quality of life, high symptom burden, complex treatment decisions, and frequent hospitalizations on patients, family caregivers, and the healthcare system is significant and growing; by 2030, the prevalence of HF is projected to exceed 8 million adults with direct healthcare costs ballooning to over $77 billion annually. Despite recent guidelines recommending the early introduction of palliative care to address these considerable burdens, the development of efficacious and scalable palliative care interventions for this population remains sluggish. The proposed training and research application aligns with the NINR Strategic Plan and aims to optimize an early palliative care intervention to maximally benefit quality of life among underserved individuals living with advanced HF.

PI_NAMEs: WELLS, RACHEL D (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Advance Care Planning;Affect;African American population;Anxiety;automated text message;Behavior Therapy;Cardiomyopathies;Care given by nurses;Caregivers;Cities;Clinical Investigator;Clinical Trials;Communication;Complex;Consultations;Data;Decision Making;design;Development;Disease;Doctor of Philosophy;Dose;Educational workshop;Effectiveness;emotional distress;Enrollment;experience;Family Caregiver;Feedback;follow-up;formative assessment;Funding;Future;Goals;Guidelines;Health Care Costs;health care service utilization;health related quality of life;Health Services Accessibility;Healthcare;Healthcare Systems;Heart failure;Hospitalization;Hospitals;improved;improved outcome;Individual;innovation;Intervention;intervention effect;Interview;Kansas;Knowledge;Knowledge acquisition;Lead;Learning Skill;Life;Maintenance;Manuals;Measures;Mediator;Mental Depression;Mentorship;Methods;Modeling;Moods;Morbidity - disease rate;mortality;multiphase optimization strategy;older adult;Outcome;Outpatients;Pain intensity;Pain interference;Palliative Care;Participant;Patient-Focused Outcomes;Patients;Persons;Phase;pilot test;Population Intervention;post intervention;Postdoctoral Fellow;Prevalence;primary outcome;Problem Solving;Procedures;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;Research;Research Ethics;Research Personnel;Research Priority;Research Training;rural dwellers;secondary outcome;Self Care;Self Efficacy;skills;sociodemographics;Strategic Planning;Structure;symposium;Symptom Burden;symptom management;Symptoms;System;systematic review;Telephone;telephone session;Testing;Training;Translating;Underserved Population;Work

PROJECT_TITLE: Optimizing an Early Palliative Care Intervention for Advanced HF Patients

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(79)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Epilepsy;Neurodegenerative;Neurosciences;Sleep Research

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Emerging data demonstrate that most people with epilepsy are more likely to have seizures at certain times of the day. However, the mechanisms that underlie these daily rhythms in seizures remain unclear. This proposal seeks to leverage the power of the fly model system to identify underlying cellular and circuit mechanisms, with the end goal of identifying novel therapeutic targets and improving our ability to predict seizure occurrence.

PI_NAMEs: CUDDAPAH, VISHNU ANAND (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TITLE: Regulation of seizure timing by circadian rhythms and sleep

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: HARRISONBURG

ORG_DEPT: BIOLOGY

ORG_NAME: JAMES MADISON UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health as it focuses on the function of genes related to autism spectrum disorder, which affects over 1 in 59 American children. The purpose of this study is to understand how integrin beta 3, an autism susceptibility gene, is necessary for the proper formation of brain circuits. Therefore, this research will provide fundamental knowledge about the brain that will inform new strategies for treating autism spectrum disorder and other neurodevelopmental disorders.

PI_NAMEs: VIDAL, GEORGE  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Advisory Committees;Affect;Age;American;Anatomy;Area;autism spectrum disorder;autistic behaviour;Award;Axon;Behavior;Behavioral;Binding;Brain;career;Cell Adhesion Molecules;cell motility;Cell Physiology;cell type;Cells;Cerebral cortex;Child;conditional knockout;critical period;Data;Dendrites;Dendritic Spines;density;design;Development;developmental neurobiology;Diagnosis;Electrophysiology (science);Embryo;Equilibrium;Event;excitatory neuron;Extracellular Matrix;Funding;gene function;Goals;Growth;hippocampal pyramidal neuron;In Vitro;in vivo;innovation;Institution;Integrin beta Chains;Integrins;Intellectual functioning disability;ITGB3 gene;Knock-out;Knowledge;Lead;Link;loss of function;Mediating;Mentors;Mentorship;migration;Morphology;Mus;Mutation;National Institute of Neurological Disorders and Stroke;Nervous System;neural;Neurites;Neuroanatomy;Neurodevelopmental Disorder;Neuroglia;neuroimmunology;Neuronal Plasticity;Neurons;novel therapeutic intervention;Physiological;Positioning Attribute;postnatal;Prefrontal Cortex;Process;professor;programs;Public Health;reconstruction;Research;Role;Secure;Shapes;Social Behavior;Structure;Susceptibility Gene;synaptic function;Synaptic Transmission;Telencephalon;tenure track;Testing;United States National Institutes of Health;Universities;Virginia

PROJECT_TITLE: Integrin Functions in Shaping Cortical Circuits


ADMINISTERING_IC: CA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: New Haven

ORG_NAME: MODIFI BIOSCIENCES INC

ORG_STATE: CT

PHR: PROJECT NARRATIVE Loss of O6-methylguanine methyltransferase (MGMT) expression is common in cancers and confers sensitivity  to DNA alkylators, such as temozolomide (TMZ). Clinically, MGMT promoter demethylation is rare, whereas  MMR mutations occur frequently as a dominant mechanism of resistance to TMZ in many tumor types. KL50  Therapeutics, LLC is developing MGMT dependent–MMR independent alkylating agents that are anticipated to  possess the positive attributes of TMZ, while circumventing the unavoidable MMR loss mediated resistance  mechanism and, thereby, have a major impact on the way we treat GBMs and other tumors lacking MGMT.

PI_NAMEs: VOVIS, GERALD FRANCIS (contact)

PROGRAM_OFFICER_NAME: BOZZA, WILLIAM PATRICK

PROJECT_TERMS: Achievement;Adenine;Alkylating Agents;Alkylation;analog;Apoptosis;Base Pairing;Biological Markers;Cell Line;Cells;Central Nervous System;Chemistry;Clinical;Collection;Colon Carcinoma;Data;Defect;demethylation;Development;DNA;DNA biosynthesis;DNA lesion;DNA Repair;DNA-Directed DNA Polymerase;Dose;Drug Kinetics;Drug resistance;Electronics;epigenetic silencing;Excision;Exhibits;Futile Cycling;Genome;Glioblastoma;Glioma;glioma cell line;Hydrogen;Hypermethylation;improved;in vitro activity;in vivo;inhibitor;Isocitrate Dehydrogenase;Laboratories;Lead;lead optimization;Lesion;Lomustine;Malignant Neoplasms;manufacture;Maximum Tolerated Dose;Mediating;Methyltransferase;Mismatch Repair;Modeling;mouse model;Mus;Mutation;Non-Small-Cell Lung Carcinoma;novel;Oncology;Pathway interactions;Patients;Penetrance;Penetration;Phase;Phase I Clinical Trials;Plasma;Positioning Attribute;pre-Investigational New Drug meeting;preclinical development;Predisposition;promoter;Property;Recurrence;Refractory;repaired;Resected;Resistance;resistance mechanism;Rodent;Safety;Series;Small Business Innovation Research Grant;small cell lung carcinoma;small molecule;success;Synthesis Chemistry;temozolomide;Testing;Therapeutic;Therapeutic Index;Thymine;Toxicology;Translational Research;tumor;tumor xenograft;Universities;Xenograft Model

PROJECT_TITLE: Development of Targeted Damaging Agents for the Treatment of Drug-Resistant Gliomas


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: Project Narrative Retinitis Pigmentosa is a blindness disease in which rod phtoreceptors, which are necessary for night vision, degenerate due to inherited mutations, and subsequently, cone photoreceptors, which provide humans with daylight color vision, degenerate for unknown secondary reasons. In mouse models of Retinitis Pigmentosa, which recapitulate the human disease progression, the disease progression is recapitulated, but interestingly, some cone photoreceptors in the peripheral retina survive long-term. By elucidating the molecular and cellular mechanisms that impart survival to the peripheral cone photoreceptors, this proposed research aims to develop novel therapeutic approaches to promote cone survival in all regions of the retina, leading to preservation of daylight color vision.

PI_NAMEs: AMAMOTO, RYOJI  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Age;Amacrine Cells;Antibodies;Blindness;Blood;Blood - brain barrier anatomy;Blood Vessels;Blood-Retinal Barrier;career;career development;cell type;Cells;cellular targeting;Central Nervous System;Cessation of life;Chimeric Proteins;Color Visions;conditional knockout;Cone;Disease;Disease Progression;Dominant-Negative Mutation;Electroporation;Environment;Enzymes;Etiology;Exhibits;experimental study;Eye;Foundations;Future;Gene Deletion;gene discovery;gene regulatory network;gene replacement therapy;gene therapy;Genes;genetic manipulation;Genetic Transcription;Genotype;Goals;Grant;Heterogeneity;Human;human disease;in vivo;in vivo Model;Inherited;intravitreal injection;Knockout Mice;Ligands;Link;LoxP-flanked allele;Mediating;medical schools;Mentors;Molecular;Molecular Target;molecular targeted therapies;mouse model;Muller's cell;Mus;Mutate;Mutation;Neurodegenerative Disorders;neuron loss;Neurons;novel;novel therapeutic intervention;overexpression;Patients;Peripheral;Persons;Pharmaceutical Preparations;Phase;Phenotype;photoreceptor degeneration;postnatal;preservation;prevent;programs;promoter;Quality of life;Research;Retina;Retinal Cone;Retinal Degeneration;Retinal Diseases;retinal rods;Retinitis Pigmentosa;retinoic acid receptor alpha;Rhodopsin;Rod;Signal Pathway;Signal Transduction;Specific qualifier value;success;Supporting Cell;Tamoxifen;Techniques;Testing;Therapeutic;Time;transcriptome sequencing;Tretinoin;Vision;VP 16;Work

PROJECT_TITLE: Elucidating the molecular and cellular mechanisms underlying cone survival in the peripheral retina in mouse models of Retinitis Pigmentosa

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: This program is a multidisciplinary, collaborative effort between investigators at the Massachusetts Institute of Technology and the New England Eye Center. The program will develop next-generation optical coherence tomography (OCT) technology for structural and blood flow imaging and perform studies in early, intermediate and late age-related macular degeneration (AMD). The objective is to better understand the mechanisms of disease and to identify structural and blood flow features in the eye that can improve diagnosis and monitoring, predict risk and accelerate pharmaceutical development.

PI_NAMEs: FUJIMOTO, JAMES G (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: Acceleration;Address;Age related macular degeneration;analog;Angiography;biomarker identification;Blood Cells;Blood flow;Blood Vessels;Bruch's basal membrane structure;Choroidal Neovascularization;Clinical;clinical imaging;Companions;Computer software;Data;Deposition;Descriptor;design;Detection;Development;Diagnosis;Diagnostic;Disease;Disease Marker;Drusen;Dyes;Early identification;Exudate;Exudative age-related macular degeneration;Eye;eye center;fovea centralis;geographic atrophy;Growth;Histopathology;Image;imaging modality;Imaging technology;Impairment;improved;in vivo;instrument;instrumentation;Investigation;Lasers;Lesion;Localized Lesion;Location;Longitudinal Studies;Maps;Massachusetts;Measurement;Measures;Methods;Modeling;Monitor;Morphology;Motion;multidisciplinary;New England;next generation;novel;Optical Coherence Tomography;Optics;Pathogenesis;Pathology;Patients;Pattern;Pharmacologic Substance;Photoreceptors;Population;programs;progression marker;Protocols documentation;Research;Research Design;Research Personnel;Resolution;Retina;Risk;Risk Factors;risk prediction;Scanning;shear stress;software development;Source;spatiotemporal;Speed;Structural defect;structural imaging;Structure;Structure of retinal pigment epithelium;Surface;Technology;Thick;three-dimensional visualization;Time;ultra high resolution;Visit

PROJECT_TITLE: Novel Optical Diagnostics with Optical Coherence Tomography

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


NIH_SPENDING_CATS: Aging;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Social Determinants of Health

PHR: Project Narrative The International Workshop on HIV & Aging is a unique forum for scientific exchange on improving the clinical care of the increasing number of people aging with HIV. We propose to enhance the 2023 Workshop by providing scholarships to early stage investigators and investigators and speakers from low and middle income countries.

PI_NAMEs: MARGOLICK, JOSEPH B. (contact)

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: Address;Adopted;Advocate;Affect;Age;Aging;aging process;aging related;aging related disease;antiretroviral therapy;Area;Biology of Aging;Cardiovascular Diseases;care providers;career;career development;Caring;Cause of Death;Chronic Disease;Chronology;Clinical;clinical care;Collaborations;comorbidity;Complex;cost effective;COVID-19 pandemic;Discipline;Disease;Educational workshop;Elderly;Evaluation;experience;Face;Feedback;Financial Support;forging;Fostering;frailty;Funding;Future;General Population;Geography;Geriatrics;Goals;Health;healthspan;HIV;HIV Infections;human old age (65+);Impaired cognition;improved;Industrialization;International;investigator training;Knowledge;lectures;Life Expectancy;Life Experience;life span;Liver diseases;Long-Term Care for Elderly;low and middle-income countries;Malignant Neoplasms;Medical;meetings;Methods;Modeling;Older Population;Oral;peer;Penetration;Pennsylvania;Persons;Policy Maker;Population;posters;prospective;Research;Research Personnel;Resource-limited setting;Resources;Restaurants;Schedule;Scholarship;Site;social;social disparities;social stigma;Source;Specialist;Stroke;success;symposium;Syndrome;System;Training;Translational Research;Universities;virtual;Washington;Work

PROJECT_TITLE: 14th International Workshop on HIV & Aging

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biomedical Imaging;Chronic Pain;Hematology;Neurosciences;Pain Research;Physical Injury - Accidents and Adverse Effects;Rehabilitation

ORG_CITY: STANFORD

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Poor recovery from orthopaedic injury, including severe pain and impaired bone healing, affects millions of Americans. Myeloid-lineage cells (peripheral macrophages and spinal cord microglia) are mobilized to resolve tissue damage, however, persistent activation of these cells can be detrimental by contributing to pain and delayed healing. This work aims to develop approaches to monitor dysfunctional myeloid-lineage cells and modulate specific targets for novel therapeutics that will improve post-injury recovery.

PI_NAMEs: TAWFIK, VIVIANNE L (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Acute Pain;Affect;Affective;American;attenuation;bone fracture repair;bone healing;bone imaging;Cell Lineage;Cells;cellular targeting;chronic pain;Clinical;Complex;critical period;cytokine;Etiology;Functional disorder;Functional impairment;genetic manipulation;glial activation;healing;Human;immune activation;Immune system;Impaired healing;Impairment;improved;improved outcome;in vivo monitoring;Individual;Infiltration;Injury;injury recovery;Innate Immune Response;Intervention;Knowledge;Ligands;Link;Long term disability;Macrophage;Microglia;Molecular;Molecular Profiling;Molecular Target;Monitor;Motivation;mouse model;Myelogenous;new therapeutic target;novel marker;Operative Surgical Procedures;Orthopedics;Pain;Perioperative;Peripheral;Persistent pain;Persons;Positioning Attribute;Positron-Emission Tomography;Recovery;Research;response;response to injury;Risk;serial imaging;Spinal Cord;Surgical Injuries;Tissues;Transgenic Organisms;Trauma;Traumatic injury;Whole Organism;Work;Yolk Sac

PROJECT_TITLE: Myeloid lineage targeting to improve recovery from injury and surgery: Cellular and molecular mechanisms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ADMINISTERING_IC: OH

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: SOCORRO

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NEW MEXICO INST OF MINING & TECHNOLOGY

ORG_STATE: NM

PHR: PROJECT NARRATIVE Despite significant improvements in mine emergency response, self-escape and mine rescue operations are still high-risk operations with potentially devastating consequences. We propose to design and develop new autonomous and AI-based technologies and strategies to improve mine evacuation and mine rescue. We will incorporate the outcomes of the project into a comprehensive AR/VR and hybrid training products for mine emergencies.

PI_NAMEs: MOJTABAI, NAVID  (contact)

PROJECT_TITLE: Design and demonstration of intelligent mine evacuation and mine rescue system


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: ROLLA

ORG_NAME: MISSOURI UNIVERSITY OF SCIENCE & TECHNOLOGY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The U.S. mining industry remains one of the most dangerous and challenging environments for workers according to the Bureau of Labor Statistics (BLS), and the Mine Safety and Health Administration (MSHA). BLS and MSHA show that mining fatality rate is five times higher than other U.S. industries with an average of 36 fatalities per year within 2009 and 2018. This research initiative will reduce miners’ risk of traumatic injuries and fatalities in underground mine emergencies via new wireless communication, improved human-robot interactions, and refuge alternatives, and mine fire and explosions response and evacuation management.

PI_NAMEs: ALAGHA, LANA Z;AWUAH-OFFEI, KWAME ;BAKER, DENISE A;FRIMPONG, SAMUEL  (contact);JOHNSON, CATHERINE E;MADRIA, SANJAY ;NADENDLA, VENKATA S;PERRY, KYLE ;SHERIZADEH, TAGHI ;SILVA CASTRO, JHON ;XU, GUANG

PROJECT_TITLE: Research, Technological Innovations and Human Factors for Effective Miner Self-Escape from Underground Mine Emergencies


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Emerging Infectious Diseases;HIV/AIDS;Heart Disease;Heart Disease - Coronary Heart Disease;Infectious Diseases;Prevention

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative The REPRIEVE trial assesses whether statins can prevent heart disease in people with HIV, a group at increased risk for heart attack and stroke, but without an established prevention strategy. REPRIEVE also determines the impact of statins on plaque in the arteries of the heart and blood markers of inflammation, and characterizes the COVID-19 pandemic in HIV. REPRIEVE completed enrollment of 7,770 participants in 2019; the proposed REPRIEVE extension will provide necessary time to collect the heart attack and stroke events crucial to address the REPRIEVE aims.

PI_NAMEs: LU, MICHAEL TSE-YIN (contact);RIBAUDO, HEATHER JANE

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: Address;adjudication;AIDS clinical trial group;Ancillary Study;Angiography;archive data;Authorization documentation;Biological Assay;Biological Markers;Biology;Blood;Blood Vessels;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;Cardiovascular system;Clinical;Clinical Data;Clinical Trials;Clinical Trials Data Monitoring Committees;cohort;Collaborations;Collection;Companions;Computers;Coronary artery;coronary computed tomography angiography;COVID-19;COVID-19 impact;COVID-19 pandemic;Data;data acquisition;Data Analyses;Data Analytics;data archive;Data Collection;Data Coordinating Center;data exchange;data management;Data Reporting;data repository;data sharing;design;Disease;efficacy evaluation;Electronic Mail;Enrollment;Ensure;Epidemiology;Equation;Event;follow-up;heart disease prevention;high risk;HIV;imaging study;immune activation;inflammatory marker;Information Dissemination;Infrastructure;Investments;Knowledge;Laboratories;Lead;Leadership;Letters;medical specialties;meetings;Methodology;Morphology;Myocardial Infarction;National Heart, Lung, and Blood Institute;Outcome;Participant;Persons;Placebo Control;pragmatic trial;Preparation;prevent;Prevention strategy;primary endpoint;Primary Prevention;Procedures;Process;protocol development;Publications;Quality Control;Randomized;randomized trial;Reporting;Research;Research Design;response;Risk;SARS-CoV-2 infection;Site;Statistical Data Interpretation;Stroke;stroke event;Structure;System;Time;tool;Training;trial design;United States National Institutes of Health;vascular inflammation;X-Ray Computed Tomography

PROJECT_TITLE: 2/2 REPRIEVE Extension for Trial Completion


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

PHR: NARRATIVE The proposed preclinical studies will investigate the consequences of blast-induced traumatic brain injury (TBI), one of the most important issues facing our Veterans. We propose to conduct a comparative study of the effect of and recovery from blast tube induced injury in eight strains of mice that capture more than 90% of the genetic variation in commonly used laboratory mice. This work will improve our understanding of genes that contribute to variations in susceptibility and/or recovery from TBI, and thus will benefit the long-term health of our Veteran population by laying the foundation for future mechanism-based studies of therapeutic agents to blunt neurodegenerative sequelae and promote functional restoration following blast-TBI.

PI_NAMEs: CULLEN, DANIEL KACY (contact)

PROJECT_TERMS: Address;Animals;behavior test;Behavioral;Biomedical Engineering;blast exposure;Body System;Certification;Cognitive deficits;Collaborations;Communities;Comparative Study;Data;Data Set;Dimensions;discrete time;Doctor of Philosophy;Doctor of Veterinary Medicine;Equilibrium;Exposure to;Formulation;Foundations;functional restoration;Future;Gene Expression;Gene Expression Profiling;Genes;Genetic;Genetic Variation;Genomics;Genotype;Health;Heart;Immunohistochemistry;improved;Incidence;Injury;Intestines;Kidney;Knowledge;Laboratory mice;Learning;Lung;mass spectrometric imaging;Measures;Medical center;Memory;military veteran;morris water maze;mortality;Motor;motor deficit;Mouse Strains;Mus;Nature;Nerve Degeneration;neurobehavioral;Neurologic;neuropathology;neurosurgery;novel;object recognition;Organ;Pathologic;Pathologist;Pathology;Pennsylvania;preclinical study;Predisposition;pressure;Principal Component Analysis;programs;Proteins;quantitative imaging;Recording of previous events;Recovery;Regional Anatomy;Request for Applications;Research;Research Personnel;resilience;response;Spleen;Statistical Models;Technology;Testing;Therapeutic Agents;Therapeutic Studies;Time;transcriptome;transcriptome sequencing;Traumatic Brain Injury;Traumatic Brain Injury recovery;Tube;Universities;Variant;Veterans;Veterinary Medicine;Veterinary Schools;War;Work

PROJECT_TITLE: SDR: Genomic analysis of blast tube induced TBI in mice


ORG_CITY: NASHVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: TN

PHR: Gastric cancer is the second most common cause of cancer-related death worldwide. American military actions often expose soldiers to areas with higher prevalence for gastric cancer and increasingly immigrants from high gastric cancer regions in South America are playing a greater role in the US military. Thus, gastric cancer represents a probable increased risk for future Veterans. Given the dismal overall survival for patients with gastric cancer, identification of pre-cancerous lesions and the development of strategies to arrest the progression or even reverse these changes is a high priority. The present proposed investigations seek to establish a greater knowledge of the induction and reversibility of pre-cancerous metaplastic changes in the stomach and evaluate novel approaches to arresting pre-cancerous changes.

PI_NAMEs: GOLDENRING, JAMES RICHARD (contact)

PROJECT_TERMS: Acute;American;Antral;Area;assault;Atrophic;Atrophic Gastritis;Autophagocytosis;Cancer Etiology;Caustics;Cell Cycle;Cell Differentiation process;Cell Lineage;Cell Proliferation;Cell Reprogramming;Cell secretion;Cell surface;Cells;Cessation of life;Chief Cell;Chromatin;Chronic;cohort;Cystine;Cytoplasmic Granules;Development;Down-Regulation;Dysplasia;Enzyme Precursors;Epithelium;Event;Evolution;Funding;Future;Gastric Adenocarcinoma;gastric carcinogenesis;gastric corpus;Gastric mucosa;Gastric Parietal Cells;Genes;Genetic Transcription;Gland;Goblet Cells;Helicobacter Infections;Helicobacter pylori;High Prevalence;Human;Hyperplasia;Immigrant;Inflammation;Inflammatory;inhibition of autophagy;Injury;insight;Intervention;Intestinal Metaplasia;Intestines;Investigation;Knowledge;Lesion;Localized Lesion;Malignant Neoplasms;malignant stomach neoplasm;Maps;Mediating;Mediation;Mediator;Messenger RNA;Metaplasia;Metaplastic Cell;MicroRNAs;Military Personnel;Mucous body substance;Mucous Membrane;Mus;Neoplasms;neoplastic;novel;novel strategies;Pathway interactions;Patients;Phosphoproteins;Phosphorylation;Play;premalignant;prevent;Probability;Process;Production;programs;Protein Secretion;Proteins;Protocols documentation;Reactive Oxygen Species;Regional Cancer;repaired;response;Risk;Role;Series;SFN gene;Signal Transduction;single-cell RNA sequencing;Soldier;South America;spasmolytic polypeptide;stem cells;Stomach;stomach body;System;Transcript;transcription factor;transcriptome;transdifferentiation;Translation Alteration;Translations;Up-Regulation;validation studies;Veterans;Zymogen Granules

PROJECT_TITLE: Oxyntic Atrophy and Novel Gastric Lineages


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: WINSTON-SALEM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROGRAM NARRATIVE Training the next generation of scientists to carry on research in substance abuse is a critical goal of the National Institute on Drug Abuse. The renewal of our T32 training grant continues the long tradition of training predoctoral researchers at Wake Forest School of Medicine in designing studies to understand the neurobiological changes that occur in the brain to mediate the process of drug addiction.

PI_NAMEs: JONES, SARA RAULERSON (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Drug abuse;Neurobiology

PROJECT_TITLE: The Neurobiology of Drug Abuse


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Neurosciences;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: Chicago

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Herpes simplex virus is the most common cause of infectious blindness and fatal viral encephalitis in the Western countries. This research is designed to investigate the mechanism of viral pathogenesis, which may facilitate the development of novel vaccines for prophylactic or therapeutic intervention.

PI_NAMEs: HE, BIN  (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Address;Afferent Neurons;Amino Acid Motifs;Anti-viral Agents;Anti-viral Response;Autophagocytosis;Autophagosome;Biological;Blindness;cell injury;Cells;Central Nervous System;Clinical;Complex;Cornea;Country;cytokine;Data;design;Development;Disease;DNA;DNA Viruses;Elements;Epithelial Cells;Epithelium;Event;Excision;Gene Expression;Gene Expression Profiling;gene function;gene product;gene translocation;Genes;Genetic Determinism;Genetic study;Golgi Apparatus;Growth;Herpes encephalitis;Herpes Simplex Infections;Herpesvirus 1;Herpetic Keratitis;Human;Human Herpesvirus 2;Immunity;Immunologic Factors;Impairment;in vivo;Individual;Infection;Inflammation;innate immune pathways;insight;Integration Host Factors;Interferons;Invaded;Knock-out;Lesion;Licensing;Link;Lytic Phase;Mammalian Cell;Mediating;Modeling;Molecular;Mucous Membrane;Mus;Mutate;Nature;Nervous System;Neurons;neurovirulence;novel;novel vaccines;Nucleic Acids;Pathway interactions;Penetration;Peripheral;Phenotype;pressure;Primary Infection;Process;Production;programs;prophylactic;Proteins;reactivation from latency;Recombinants;Recurrence;recurrent infection;Research;response;Signal Transduction;Simplexvirus;Source;TANK-binding kinase 1;Therapeutic Intervention;Tissues;trafficking;Translations;Travel;TRIM Motif;Ubiquitination;Vaccines;Viral;Viral Encephalitis;Viral Interference;Viral Pathogenesis;Viral Proteins;Virulence;Virulence Factors;Virus;Virus Diseases;virus host interaction;Virus Replication

PROJECT_TITLE: Viral determinants in HSV virulence

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Infectious Diseases;Nutrition

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

PHR: The gut immune system must maintain tolerance n the steady-state while retaining the ability to rapidly induce immunity to pathogens during infection. We have uncovered an intrinsic capacity of the gut to switch from tolerance to immunity and propose this is a physiologic response to infection and when inappropriately activated potentially contributes to intestinal inflammatory diseases.

PI_NAMEs: HSIEH, CHYI S;NEWBERRY, RODNEY D (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: adaptive immune response;Address;Antigen-Presenting Cells;Antigens;Autoantigens;Automobile Driving;Biological Assay;Cell Differentiation process;Cells;Chemicals;chronic inflammatory disease;Collection;cytokine;Development;Diet;dietary;Early identification;Ecosystem;enteric infection;Epithelial Cells;Epithelium;Equilibrium;Event;Exposure to;Flow Cytometry;Gastrointestinal tract structure;Gene Expression;Generations;Gnotobiotic;Goblet Cells;gut inflammation;Homeostasis;Immune;Immune response;Immune system;Immunity;Immunologics;in vivo;Infection;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;Injury;insight;intestinal epithelium;Lamina Propria;Maps;Microbe;microbial;microbiota;microorganism antigen;Modeling;Monitor;Mucous body substance;Mus;novel strategies;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Phenotype;Physiological;Process;Property;Regulatory T-Lymphocyte;Reporter;response;Role;Severities;Small Intestinal Goblet Cell;Small Intestines;Specificity;Surface;T-cell receptor repertoire;T-Lymphocyte;transdifferentiation;Transgenic Mice

PROJECT_TITLE: Gut Intrinsic Inflammatory Responses


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Congenital Structural Anomalies;Intellectual and Developmental Disabilities (IDD);Mucopolysaccharidoses (MPS);Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: BROOKLYN

ORG_NAME: PHOENIX NEST, INC.

ORG_STATE: NY

PHR: Project Narrative Our enzyme replacement therapy program has achieved goals set on Phase I STTR, Phase II SBIR and continuing to make strides towards achieving our goals for Phase II SBIR. To support IND filing and initiation of the interventional clinical trial we need this CRP grant to support execution of this trial for identification of critical measurable clinical outcome and potential biomarkers. These data will ultimately support commercialization the first therapy for MPS IIID.

PI_NAMEs: SINGAMSETTY, SRIKANTH  (contact)

PROGRAM_OFFICER_NAME: CAPORELLO, EMILY LAURA

PROJECT_TERMS: Affect;analytical tool;arm;Authorization documentation;Awareness;Behavior;Behavioral;Biochemical;Biochemical Markers;biomarker development;Brain;Case Study;Cessation of life;Childhood;Clinic;Clinical;Clinical Data;clinical outcome assessment;clinical outcome measures;clinical predictors;Clinical Protocols;Clinical Research;Clinical Services;clinical trial protocol;Clinical Trials;Clinical Trials Design;clinically relevant;CLN2 gene;Cognitive;cohort;Collaborations;commercialization;Communities;compare effectiveness;Consultations;Contract Services;control trial;Data;Data Collection;Dementia;design;Development;Development Plans;Diagnosis;Dimensions;Disease;Disease Progression;disease registry;drug development;Drug Evaluation;efficacy evaluation;Electrophysiology (science);Emotional;Enrollment;enzyme replacement therapy;Enzymes;Evaluation;expectation;experience;Foundations;Genotype;Goals;Grant;Human;Image;Immobilization;Impaired cognition;Individual;Infusion procedures;innovation;International;Intervention;Intervention Studies;Intervention Trial;Investigational Therapies;Legal patent;Letters;Licensing;Literature;manufacture;Measurable;Measurement;Measures;Medical History;meetings;mobile application;Molecular;Molecular Diagnosis;molecular marker;Monitor;Morals;Motor Skills;Mucopolysaccharidoses;Mucopolysaccharidosis I;Mucopolysaccharidosis II;Mucopolysaccharidosis III;Natural History;Nerve Degeneration;Neurocognitive;Neurologic;Neurologic Symptoms;Neuropsychology;Outcome;Outcome Measure;outreach;participant enrollment;Pathologic;Pathology;Patient Outcomes Assessments;patient population;Patients;Phase;phase I trial;Phenotype;potential biomarker;Preparation;primary endpoint;Principal Investigator;Problem behavior;product development;Program Development;programs;prospective;Protocols documentation;Publications;Quality of life;randomized placebo controlled study;Rare Diseases;Recombinants;Recommendation;Records;Research;research clinical testing;Research Design;Research Personnel;Scientist;service providers;Small Business Innovation Research Grant;Small Business Technology Transfer Research;Spielmeyer-Vogt Disease;standard of care;success;Sulfatases;Surrogate Markers;Surveys;symposium;symptomatology;Technology;Time;timeline;tool;Treatment Efficacy;treatment planning;treatment response;Validation;Variant;Visit;Work;Writing

PROJECT_TITLE: Evaluation of Clinical Outcome Assessment (COA) and Potential Biomarkers to Facilitate Interventional Trial for Mucopolysaccharidosis IIID Patients


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: PROJECT NARRATIVE Alzheimer’s Dementia (AD) is a leading cause of cognitive dysfunction and death, but is lacking effective treatment. Cellular senescence has recently been implicated in age related disease pathology, including AD. The work outlined in this proposal will provide insight into the role of a newly described senescent cell population that may lead to a better understanding of AD and the development of new AD therapies.

PI_NAMEs: GASEK, NATHAN  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Address;Age;age related;age-related disease;Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;Animals;Apoptotic;APP-PS1;Automobile Driving;Behavioral;Biological Assay;Biology of Aging;Brain;burden of illness;career;career development;Cell Aging;Cell Cycle;Cell Cycle Proteins;Cell Nucleus;cell type;Cells;Cessation of life;Characteristics;clinical practice;Cognitive;Cognitive deficits;Communication;Computer Analysis;Data;Dementia;Deposition;Development;Development Plans;Disease;drivers of aging;effective therapy;Elderly;Enterobacteria phage P1 Cre recombinase;Excision;experimental study;Fluorescence;Functional disorder;Future;Genetic Transcription;Goals;Growth;Health;Heterogeneity;Histologic;Human;Immunohistochemistry;Impaired cognition;Impairment;improved;inducible Cre;Inflammatory;insight;Link;Literature;LoxP-flanked allele;Mentorship;Metabolic Diseases;Metabolic stress;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Neurodegenerative Disorders;neuroinflammation;neuron loss;Neurons;new therapeutic target;novel;novel therapeutics;Oxidative Stress;Pathogenesis;Pathology;Pathway interactions;Performance;pharmacologic;Physicians;Play;Population;prevent;Process;Production;promoter;Proteins;regenerative;Reporter;Research;Resistance;Resolution;Role;Scientist;senescence;senescent cell;Senile Plaques;single cell sequencing;single nucleus RNA-sequencing;stressor;suicide gene;System;tau aggregation;tau Proteins;Testing;therapeutic target;timeline;Tissues;Toxin;Training;Transgenic Mice;Transgenic Organisms;wasting;Work

PROJECT_TITLE: Investigating the Role of p21-Highly Expressing Senescent Cells in Alzheimer's Dementia


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease

ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative  Accomplishing these studies will establish a novel post-translational modification code essential for cardiac reprogramming. The findings will reveal new insights into fundamental post-translational modification and epigenetic mechanisms that define cell plasticity and govern cardiac reprogramming. These studies will provide a novel framework for decoding post-translational modifications in cell reprogramming and organ regeneration.

PI_NAMEs: WANG, ZHONG  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Acetylation;Animal Model;Automobile Driving;Binding;Cardiac;Cardiac Myocytes;cardiac repair;Cell Differentiation process;Cell Fate Control;Cell Reprogramming;Cells;Chromatin;chromatin remodeling;clinically relevant;Code;Development;Enzymes;Epigenetic Process;Evolution;Fibroblasts;Foundations;GATA4 gene;Gene Expression Regulation;Genetic Transcription;HDAC4 gene;Histone H3;histone modification;Histones;Human;in vivo;insight;Investigation;Knowledge;Mediating;Methylation;Molecular;mouse model;Mus;Myocardial Infarction;myocyte-specific enhancer-binding-factor 2C;novel;organ growth;organ regeneration;Output;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Play;Post-Transcriptional Regulation;Post-Translational Protein Processing;pre-clinical;Process;programs;Protein Dynamics;Protein Phosphatase 2A Regulatory Subunit PR53;Proteins;Role;System;tandem mass spectrometry;Testing;Therapeutic;transcription factor;Translating;Work

PROJECT_TITLE: Dissecting a post-translational modification code in cardiac reprogramming

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: The research in this application will contribute to the fundamental knowledge of the metastatic disease by addressing the biology and heterogeneity of disseminated tumor cells (DTCs). The data obtained from this proposal will help to design therapies to extend the metastasis-free periods and monitor disease progression.

PI_NAMEs: SOSA, MARIA  (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: Address;Agonist;Bar Codes;Biological Markers;Biology;Bone Marrow;cancer cell;Cancer Etiology;Cancer Relapse;cell behavior;Cell Cycle Arrest;Cell Survival;Cessation of life;chemotherapy;ChIP-seq;Chromatin;chromatin remodeling;Clinical;Clinical Trials;conventional therapy;COUP transcription factor I;Data;design;Detection;Disease;Disease Progression;Disease remission;Distant;Endowment;Enhancers;Frequencies;gain of function;Genes;Genetic Transcription;Goals;Grant;Head and Neck Squamous Cell Carcinoma;Heterogeneity;Human;Individual;insight;Knowledge;LIF gene;loss of function;Lung;lymph nodes;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Metastatic Prostate Cancer;Modeling;Molecular;Monitor;mortality;Neoplasm Metastasis;neoplastic cell;oncostatin M;Organ;Organ Culture Techniques;Pathway interactions;Patients;Phase;pluripotency;Population;predictive marker;Prevalence;prevent;Prevention;Primary Neoplasm;programs;Proliferating;Protocols documentation;Publishing;Recurrence;Regulation;Relapse;Reporting;Repression;Research;Residual Neoplasm;response;Risk Factors;Role;Sampling;Signal Transduction;STAT3 gene;stemness;Technology;Testing;Therapeutic;therapeutic development;therapy design;Time;transcription factor;transcriptome sequencing;treatment response;Tretinoin;tumor;Tumor Cell Biology;Validation;Work

PROJECT_TITLE: Functional Analysis of Distinct and Co-existing Transcriptional Programs Regulating Tumor Dormancy

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Kidney Disease;Patient Safety;Precision Medicine

ORG_CITY: SAN FRANCISCO

ORG_NAME: NORTHERN CALIFORNIA INSTITUTE/RES/EDU

PHR: PROJECT NARRATIVE Kidney complications occur commonly during heart failure treatment and strongly influence treatment decisions. However, current methods for monitoring kidney health are suboptimal. This proposal will develop a panel of kidney health biomarkers that could enable kidney-safe, effective treatment of heart failure.

PI_NAMEs: ESTRELLA, MICHELLE M (contact);TESTANI, JEFFREY M

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Acute;Address;Adult;Adverse event;adverse outcome;Affect;Albuminuria;Biological Markers;biomarker panel;Body Weight Changes;cardiovascular health;Caring;Clinical;clinical care;Clinical Data;clinical decision-making;clinical prognostic;Clinical Trials;cohort;Collection;common treatment;Congestive Heart Failure;cost;Creatinine;diagnostic strategy;Dimensions;Discharge Plannings;Diuresis;Diuretics;Dose;effective therapy;effectiveness evaluation;Fibrosis;follow-up;Foundations;Fright;Goals;Guidelines;Health;Health Status;Heart failure;hemodynamics;high risk;HIV Infections;hospital readmission;Hospitalization;Hospitals;Hour;Hypertension;Impairment;improved;Individual;individual patient;individualized medicine;Inflammation;Injury;Injury to Kidney;Kidney;Left;Life;Measures;Medical;Methods;Monitor;mortality;mortality risk;Natriuresis;Natriuretic Peptides;Nephrons;novel diagnostics;Oral;Outcome;Patient Discharge;patient response;Patients;Pattern;Persons;Pharmacological Treatment;Physiological;predicting response;Prediction of Response to Therapy;Prognosis;prognostic tool;prognostication;Readiness;reduce symptoms;renal damage;Renal function;Renal tubule structure;reparative capacity;Residual state;Resistance;Resort;response;Risk;risk minimization;Role;Safety;saluretic;Selection for Treatments;Serum;Severities;Testing;Therapeutic;Thiazide Diuretics;tissue injury;tool;Treatment Efficacy;Treatment Failure;treatment response;treatment strategy;Tubular formation;Visit;Work

PROJECT_TITLE: Advanced Kidney Health Monitoring in Persons Hospitalized with Heart Failure

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_DEPT: GENETICS

PHR: PROJECT NARRATIVE Circadian rhythm disruption is a common feature of Alzheimer’s disease and one of the major causes of patient institutionalization. A common mouse model of the disease has been found to exhibit a phenomenon known as circadian reprogramming, in which a subset of genes loses circadian expression while another subset gains circadian expression. This project will determine how transcription factors coordinate circadian reprogramming and generate novel circadian expression within the context of neurodegeneration, which will provide novel insight into how Alzheimer’s disease progresses and potentially uncover new pathways to alter disease course.

PI_NAMEs: REISS, INDIA H (contact)

PROJECT_TERMS: Affect;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;APP-PS1;ARNTL gene;Arrhythmia;Astrocytes;astrogliosis;Automobile Driving;Bar Codes;Binding;Binding Sites;Biological Assay;Brain;candidate identification;cell type;Cells;ChIP-seq;circadian;Circadian Dysregulation;Circadian gene expression;circadian pacemaker;Circadian Rhythms;Clock protein;Data;Dementia;Disease;disease model;DNA Binding;E-Box Elements;Environment;Event;Exhibits;experimental study;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;genomic locus;Genomics;Goals;Hour;Impaired cognition;In Vitro;in vivo;insight;Institutionalization;Libraries;Logic;Modeling;Molecular;mouse model;Mus;Nerve Degeneration;neuron loss;Neurons;novel;Nuclear;Nucleic Acid Regulatory Sequences;Oxidative Stress;Pathway interactions;Patients;Pattern;Periodicity;Phenotype;prevent;promoter;Protocols documentation;Reporter;Reporter Genes;Signal Transduction;Sleep disturbances;Technology;Testing;Transcript;transcription factor;translating ribosome affinity purification and RNA-sequencing;Wild Type Mouse

PROJECT_TITLE: Deciphering the cis-regulatory logic of circadian reprogramming in a mouse model of Alzheimer's Disease


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Osteoporosis

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Project Narrative Successful completion of these studies will identify the cellular sources of a protein, known as osteoprotegerin, that inhibits bone loss. In addition, the proposed studies may identify the cause of the rapid bone loss following discontinuation of a common type of osteoporosis therapy known as denosumab. In the long-term, these studies may identify strategies to prevent bone loss due to a variety of conditions.

PI_NAMEs: O'BRIEN, CHARLES A (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Address;Aging;Alleles;Antibodies;B-Lymphocytes;beta catenin;Binding;bone;bone loss;bone mass;Bone remodeling;Bone Resorption;Cells;clinically relevant;cortical bone;Cre driver;Cytokine Receptors;Epitopes;Equilibrium;Estrogen deficiency;Evaluation;Gene Expression Profiling;Genes;Genetic Recombination;Glucocorticoids;Goals;Histologic;intercellular communication;Knock-in Mouse;Knockout Mice;Ligands;loss of function;Maps;Measurement;Membrane;Mesenchymal Stem Cells;Modeling;Molecular;Mus;Nature;novel;Osteoblasts;Osteoclasts;Osteocytes;Osteoporosis;Pathologic;Pathway interactions;Periodicity;Physiological;Physiology;Play;prevent;Process;Production;progenitor;Proteins;receptor;response;Role;single-cell RNA sequencing;skeletal;Source;substantia spongiosa;System;Tail Suspension;transcriptome sequencing;Tumor necrosis factor receptor 11b;Vascular Endothelial Cell;Work

PROJECT_TITLE: Osteocyte Control of Bone Remodeling

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Biotechnology;Genetics;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Humans have dormant cells capable of limited regeneration, harnessing this potential requires a deeper understanding of how these cells form during development and how they are maintained in adults. The model tunicate Ciona, an invertebrate closely related to humans, shares many of our chordate genes and signaling pathways, and can use these shared mechanisms to reformulate its nervous system and regenerate its entire brain. The goal of this proposal is to shed new light on novel genetic mechanisms to control stem cells.

PI_NAMEs: GIGANTE, EDUARDO D. (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Adolescent;Adult;antagonist;Apoptosis;ascidian;Behavior;Biological Assay;Biological Metamorphosis;bone;Brain;brain cell;Bypass;C-terminal;cell behavior;Cell Differentiation process;Cell Lineage;Cell Proliferation;Cell Reprogramming;Cells;Cephalic;cholinergic neuron;Chordata;CRISPR/Cas technology;Cues;Data;Development;Developmental Biology;Disease;Embryo;Equilibrium;extracellular;Fluorescence Microscopy;Foundations;Future;Gene Expression Regulation;Genes;Genetic;genetic architecture;Genetic Transcription;genome editing;Gills;Goals;Homeobox;Homologous Gene;Human;in vivo Model;Individual;innovation;Invertebrates;Investigation;Knock-out;knockout gene;Larva;Life;Link;Maintenance;Mammals;Marine Invertebrates;Mediating;Modeling;Molecular;Motor Neurons;Muscle;mutant;Natural regeneration;Neck;nerve stem cell;Nervous System;nervous system development;neurodevelopment;Neuronal Differentiation;Neurons;new technology;novel;Organ;Organism;Outcome;Pathway interactions;Pattern;Pharyngeal structure;Play;Population;prevent;Process;progenitor;Proliferating;receptor;regeneration potential;regenerative;regenerative biology;Regenerative capacity;regenerative therapy;Regulation;Regulatory Element;repaired;Reporter;response;RNA Polymerase II;Role;Signal Pathway;Signal Transduction;Sister;spatiotemporal;Specific qualifier value;stem cell niche;stem cell population;stem cells;Stereotyping;Structure;Time;Tissues;Transcription Elongation;Transcriptional Regulation;Urochordata;Vertebrates;Work

PROJECT_TITLE: Dissecting gene regulation of stem cell quiescence in Ciona

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Hormones and neurotransmitters, as well as most pharmaceuticals, do not act in isolation but are subject to feedback regulation and cross-talk from other signaling pathways, including those that sense nutrients such as glucose. Our long term objective is to understand how cells respond to hormones under changing physiological circumstances and to predict how those circumstances affect pharmacological responses.

PI_NAMEs: DOHLMAN, HENRIK G. (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Acceleration;Affect;Autophagocytosis;Binding;Biochemical;Branched-Chain Amino Acids;Calcium;Cells;Chemicals;Cues;Cyclic AMP;detection of nutrient;Feedback;flexibility;G-Protein-Coupled Receptors;Glucose;GTP-Binding Proteins;Guanosine Triphosphate;Hormones;Hydrolysis;Investigation;Learning;Mass Spectrum Analysis;Measures;Molecular;Neurotransmitters;novel;Nutrient;Nutrient availability;Osmosis;pharmacologic;Pharmacologic Substance;Pheromone;Phosphorylation;Phosphotransferases;Physiological;programs;Proteins;receptor;reconstitution;Recycling;Regulation;Research;response;RGS Proteins;Roentgen Rays;Role;Scientist;Second Messenger Systems;Signal Pathway;Signal Transduction;Stress;Structure

PROJECT_TITLE: Negative and positive feedback in cell signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Narrative This application proposes to investigate the “clues” that can be found in HIV-1 patients that describe their likelihoods to develop resistance to Env-targeting therapeutics. Our published and preliminary studies have revealed that each strain of HIV-1 has an inherent and measurable propensity for mutations to appear at Env sites that mediate escape from each therapeutic, which can be calculated using sequence properties of the protein in an infected individual. These investigations have the potential to facilitate personalized antiviral treatment by establishing the tools to quantify the likelihood of each patient to develop resistance to each agent before initiation of therapy.

PI_NAMEs: HAIM, HILLEL  (contact)

PROGRAM_OFFICER_NAME: GEZMU, MISRAK

PROJECT_TERMS: Aftercare;Algorithms;Amino Acids;Anti-Retroviral Agents;Anti-viral Agents;Appearance;Blood;Blood Cells;Clinical;Clinical Trials;Conserved Sequence;de novo mutation;deep sequencing;Drug resistance;Exhibits;fitness;Foundations;Future;Glycoproteins;Goals;HIV;HIV-1;Human;In Vitro;in vitro testing;in vivo;Individual;Investigation;Knowledge;Measurable;Measures;Mediating;Medicine;Methods;Modeling;Molecular Cloning;Monitor;Morbidity - disease rate;mortality;mutant;Mutation;mutation screening;Nature;neutralizing antibody;Outcome;Patient Monitoring;Patients;Pattern;peripheral blood;personalized medicine;Persons;Plasma;Positioning Attribute;predictive modeling;Probability;Property;Proteins;Publishing;Reducing Agents;Resistance;Resistance development;resistance mutation;Sampling;Site;Source;Specificity;targeted treatment;Testing;Therapeutic;Therapeutic antibodies;therapeutic target;therapy resistant;Time;timeline;tool;treatment strategy;Variant;Viral;viral fitness;Viral Genome;Viral Proteins;Viral reservoir;Virus;Virus Latency;Work

PROJECT_TITLE: Predicting HIV-1 escape from therapeutics in vitro and in vivo - toward personalizing medicine for people living with HIV

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Genetics

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Perturbations of the intercellular signaling systems that control organ growth are a major source of human disease, associated with a wide range of developmental, physiological disorders as well as most forms of cancer. The proposed research is relevant to public health because solving how such systems normally function to direct as well as terminate growth as organs develop is essential for the development of more effective diagnostic and therapeutic treatments for this enormously broad range of afflictions. Thus, the proposed research is relevant to NIH's mission to reduce the burden to society arising from genetic and environmental disorders of fundamental aspects of human development and physiology.

PI_NAMEs: STRUHL, GARY  (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Animals;Body part;Bone Morphogenetic Proteins;Cells;Complement;Complex;Development;Diagnostic;Dimerization;Disease;Drosophila frizzled protein;Drosophila genus;Family;Fatty acid glycerol esters;fly;G-Protein-Coupled Receptors;Gene Expression;Gene Structure;Genes;Genetic;Genetic Enhancer Element;Goals;Growth;Health;Human;Human Development;human disease;insight;Leg;Logic;Malignant Neoplasms;man;member;Mission;Modeling;Molecular;morphogens;Organ;organ growth;Pattern;Physiological;Physiology;Porifera;programs;Protein Secretion;Proteins;Public Health;receptor;recruit;Research;response;Role;Signal Transduction;Signal Transduction Pathway;Signaling Molecule;Societies;Source;System;Testing;Therapeutic;Tissues;tool;transcription factor;Transgenic Organisms;United States National Institutes of Health;Wing;Work

PROJECT_TITLE: Morphogen control of organ growth in Drosophila

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Hematology;Infectious Diseases;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative Viral infections are a serious complication of bone marrow transplantation and children can die of them. We will test infusion of specially trained virus-fighting T-cells shortly after bone marrow transplantation to see if we can prevent viral infections.

PI_NAMEs: DAVIES, STELLA MARGARET (contact);LUTZKO, CAROLYN M

PROGRAM_OFFICER_NAME: GALIVO, FEORILLO HERRERA

PROJECT_TERMS: Acute Graft Versus Host Disease;Adenoviruses;Anti-viral Agents;Antigens;arm;BK Virus;Blood;Bone Marrow;Bone Marrow Transplantation;Cell Line;Cell Therapy;Cells;Characteristics;Child;Clinic;Clinical;Clinical Trials;combat;Complication;Cytomegalovirus;Data;Disease;donor stem cell;Double Stranded DNA Virus;effective therapy;Engineering;experimental arm;Exposure to;Failure;fighting;Frequencies;Future;Goals;graft vs host disease;Hematopoietic Stem Cell Transplantation;high risk;Hospitalization;Human Herpesvirus 4;Immune;Incidence;individual patient;Infection;Infection prevention;infection risk;Infusion procedures;Institution;Ligands;lymphocyte product;manufacture;Morbidity - disease rate;mortality risk;novel therapeutics;Organ;Patients;Pediatric Hospitals;Peptide Mapping;Persons;Phase;Prediction of Response to Therapy;prevent;programs;prophylactic;Randomized;randomized trial;Reaction;response;Risk Reduction;Schedule;standard of care;stem cell exhaustion;Stem cell transplant;stem cells;T cell receptor repertoire sequencing;T cell response;T-Cell Depletion;T-Lymphocyte;Technology;Testing;Time;Toxic effect;Training;Transplant Recipients;Transplantation;treatment arm;trial enrollment;Viral;Viral Antigens;Viremia;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Randomized trial of viral specific T-cell infusion to prevent viral infection after hematopoietic stem cell transplant.


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: MORGANTOWN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: NARRATIVE Currently, the treatment planning (surgical or radiation therapy) of head and neck cancers is hindered by the limited resolution and rigid geometry of whole body PET/CT scanners. We propose the development and testing of a novel, variable geometry, high-resolution head and neck PET/CT system to address these limitations.

PI_NAMEs: RAYLMAN, RAYMOND ROBERT (contact)

PROGRAM_OFFICER_NAME: KIM, BOKLYE

PROJECT_TERMS: Address;Algorithm Design;Algorithms;anatomic imaging;Anatomy;Area;Blinded;bone;Carotid Arteries;Characteristics;Clinic;Clinical;Clinical Trials;Collaborations;Compton radiation;Computed Tomography Scanners;Computer software;cone-beam computed tomography;cost;Data;data acquisition;design;Detection;detection sensitivity;detector;Development;Devices;Discipline of Nuclear Medicine;Dose;draining lymph node;Effectiveness;electron density;Elements;Epidemic;Esophagus;Evaluation;Excision;Feedback;flexibility;Formulation;Geometry;Goals;Head;Head and Neck Cancer;head and neck cancer patient;Head and neck structure;Head and Neck Surgery;Heterogeneity;high resolution imaging;Histologic;Human;Human Papillomavirus;Image;image guided;image reconstruction;imaging modality;imaging Segmentation;imaging system;Immersion;improved;industry partner;Infiltration;instrumentation;Intensity-Modulated Radiotherapy;Invaded;Investigation;Location;lymph nodes;Malignant Neoplasms;manufacture;Maps;Metabolic;Methods;Microscopic;Modality;Morbidity - disease rate;Motor;multidisciplinary;Multimodal Imaging;Nature;Neoplasm Metastasis;novel;novel therapeutic intervention;Operative Surgical Procedures;Paint;Parotid Gland;Patient Schedules;Patients;Performance;personalized medicine;Physiologic pulse;Planning Techniques;Positron-Emission Tomography;pre-clinical;Primary Neoplasm;Privatization;Process;Production;Protocols documentation;Radiation;radiation detector;Radiation Dose Unit;Radiation Oncology;Radiation therapy;Radiology Specialty;Radiology, Head, Neck;reconstruction;Recurrence;research clinical testing;Resolution;ROC Curve;Roentgen Rays;Role;Rotation;Salivary Glands;Scanning;Selection for Treatments;Slide;Source;Spinal Cord;Staging;Structure;Surgical Oncology;Survival Rate;System;Technology;Test Result;Testing;Thyroid Gland;Tissues;Treatment Effectiveness;treatment planning;treatment strategy;tumor;Underserved Population;Universities;uptake;Vendor;West Virginia;X-Ray Computed Tomography

PROJECT_TITLE: A PET/CT scanner for guiding treatment of head and neck cancer


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Neurosciences;Prevention;Substance Misuse;Vaccine Related

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: NARRATIVE The goals of I4C 2.0 are to advance our scientific understanding of the viral reservoir and to develop immunologic strategies for HIV-1 remission and eradication by a highly collaborative and multifaceted research program. We will evaluate combinations of state-of-the-art immunologic strategies aimed at either long-term, ART-free virologic control or complete virus eradication.

PI_NAMEs: BAROUCH, DAN H. (contact);MELLORS, JOHN W;VASAN, SANDHYA

PROGRAM_OFFICER_NAME: SANDERS, BRIGITTE E

PROJECT_TERMS: Academia;Active Immunization;Agonist;B-Lymphocytes;Binding;chimeric antigen receptor T cells;clinical development;Clonal Expansion;Communities;community engagement;Community Networks;Disease remission;Engineering;Ensure;Feedback;Financial Support;Goals;Government;HIV-1;Human;Immune;Immune response;immunoengineering;Immunologic Surveillance;Immunologics;Immunotherapy;improved;Industry;innovation;Logistics;Macaca mulatta;Monkeys;Natural Killer Cells;neutralizing antibody;novel strategies;operation;Passive Immunization;prevent;programs;Regimen;Research;Residual state;Resources;Sampling;simian human immunodeficiency virus;SIV;T-Lymphocyte;therapeutic vaccine;timeline;TLR7 gene;transcriptomics;United States National Institutes of Health;Vaccine Therapy;Viral;viral rebound;Viral reservoir;Virus

PROJECT_TITLE: I4C 2.0: Immunotherapy for Cure


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Primary Health Care

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE Effective interpersonal communication is associated with improved health related outcomes, yet it is unclear to what extent this occurs in triadic clinic visits in dementia, and few tools exist to support it. The objective of this project is to characterize the extent to which interpersonal communication occurs during triadic visits in dementia, examine how this is related to health outcomes and use this understanding to adapt an innovative clinic visit audio recording intervention, HealthPAL for use in this setting. The results are expected to have a major positive impact by providing a rich understanding of communication during triadic visits in dementia, and proof-of-principle of the usability, feasibility, and acceptability of visit audio recording to enhance interpersonal communication.

PI_NAMEs: BARR, PAUL JAMES (contact);CHODOSH, JOSHUA

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: acceptability and feasibility;Accountability;Address;Adherence;Alzheimer's Disease;Alzheimer's disease related dementia;Ambulatory Care Facilities;arm;Behavior;behavior change;behavior change wheel;Caring;Clinic Visits;Clinical;cognitive load;Communication;Communities;Computer software;Data;Decision Making;Dementia;dementia care;design;Effectiveness;Emotional;Ethnic Origin;evidence base;Exclusion;experience;Family;Federally Qualified Health Center;Feedback;follow-up;Funding;Future;Geography;Goals;Health;Health Services;human old age (65+);improved;improved outcome;information processing;innovation;Intervention;Interview;Knowledge;Lebanon;Linguistics;Maps;Methods;Modeling;Motivation;Natural Language Processing;novel;Observational Study;open label;Outcome;Patient Care;Patient Preferences;Patients;Performance;Personal Communication;Persons;pilot trial;Play;Primary Care;primary care clinic;Process;prospective;Provider;psychosocial;Quality of life;Race;Readiness;Recommendation;Reporting;Research;Resources;Role;Roter;rural health clinic;Sampling;satisfaction;Schedule;Site;skills;software development;Structure;System;Systems Analysis;Techniques;theories;therapy design;tool;Trust;trustworthiness;United States National Institutes of Health;usability;Visit;Work

PROJECT_TITLE: The Role of Visit Audio Recordings in Triadic Dementia Care


NIH_SPENDING_CATS: Aging;Genetics;Human Genome

ORG_STATE: NC

PHR: PROJECT NARRATIVE Histone proteins are essential for all DNA-dependent processes and misregulation of histones contributes to chromatin-based aging defects. This proposal aims to determine the function of variant histone H3.3 in aging cells and to gain mechanistic insight into how canonical and variant histones cooperate to regulate genome function. The principles uncovered from these studies will increase our fundamental understanding of histone regulation and could inform the development of therapeutic pathways to improve healthy aging.

PI_NAMEs: MCPHERSON, JEANNE-MARIE  (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Affect;Age;Aging;aging brain;aging process;Amino Acid Sequence;Amino Acids;ATAC-seq;Binding;brain cell;Cell Aging;Cell Cycle;Cells;Chromatin;Chromatin Structure;Cleavage Under Targets and Release Using Nuclease;Clustered Regularly Interspaced Short Palindromic Repeats;Defect;defined contribution;Deposition;Development;DNA;DNA biosynthesis;DNA Packaging;Dose;Drosophila genus;Ensure;Eukaryota;experimental study;Gene Dosage;Gene Expression;Gene Proteins;Genes;Genetic;Genetic Screening;Genetic Transcription;Genome;Genomics;Global Change;hallmarks of aging;healthy aging;Heterochromatin;Histone H3;Histone H3.3;Histones;Homeostasis;improved;insight;interest;Interphase Cell;Investigation;Knowledge;life span;Location;Longevity;Mediating;Modeling;Mutation;Pathologic;Pathologic Processes;Pathway interactions;Pattern;postmitotic;Process;protein function;Proteins;Regulation;Role;S phase;screening;Source;Testing;therapeutic development;Variant;Work

PROJECT_TITLE: Interrogating the roles of canonical versus variant histone H3 in genome function during aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Chronic Pain;Clinical Research;Neurosciences;Osteoarthritis;Pain Research;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: HADLEY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

ORG_STATE: MA

PHR: PROJECT NARRATIVE Knee osteoarthritis results in more years lived with disability compared to any other musculoskeletal condition representing a critical public health problem. By determining the biomechanical consequences of muscle fatigue in older adults with knee osteoarthritis, this project will address a knowledge gap related to the mechanisms for this disability. Our mechanistic investigation of muscle fatigue in an osteoarthritic, aging population will identify promising targets for interventions to mitigate or prevent fatigue and related mobility declines, as such, this project is highly relevant to the missions of NIH and NIA.

PI_NAMEs: HOLMES, SKYLAR  (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Accelerometer;Acute;Address;Adopted;Adult;Age;aging population;Ankle;Arthralgia;Biomechanics;Chronic;chronic pain;clinically relevant;Cross-Sectional Studies;Data;Degenerative polyarthritis;Development;disability;Distal;Electromyography;Evaluation;Exercise;Extensor;Fatigue;Female;Flexor;Functional disorder;functional improvement;Gait;Goals;healthspan;Hip region structure;Impairment;improved;improved mobility;Individual;Intervention;Investigation;Isometric Exercise;Isotonic Exercise;Joints;Knee;Knee Osteoarthritis;Knowledge;Link;male;Measures;Mechanics;Medical;men;Mission;Mobility decline;Monitor;Motion;Motor;Motor Cortex;Movement;Muscle;Muscle Fatigue;Muscle function;Muscular Atrophy;Musculoskeletal;Neurologic;Neuromechanics;neuromuscular;neuromuscular function;Neuronal Plasticity;neurophysiology;novel strategies;Numeric Rating Scale;older adult;Pain;Pattern;Peripheral;Persons;Physical activity;Physical Capacity;Physical Function;Physical Performance;Physiological;Population;prevent;Psyche structure;Public Health;Reporting;Research Design;Research Personnel;response;sedentary;sensory system;Severities;skill acquisition;Source;Speed;Spinal Cord;Standardization;Symptoms;Testing;Time;Torque;Training;Transcranial magnetic stimulation;treadmill;United States National Institutes of Health;verbal;Vulnerable Populations;Walking;Woman;Work;years lived with disability

PROJECT_TITLE: Muscle Fatigue's Impact on Gait Mechanics and Neuromuscular Control in Knee Osteoarthritis


NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_DEPT: BIOCHEMISTRY

PHR: The proposed research is relevant to public health because our development of mass spectrometry footprinting methods will be broadly applicable for the study of human membrane proteins that represent more than 60% of the drug targets and participate in almost all physiological processes. We will apply new methods we develop in native membranes and live cells to reveal the interactions of a human glucose transport protein with anticancer drug candidates and partner proteins that regulate glucose levels in the human body.

PI_NAMEs: GROSS, MICHAEL L;LI, WEIKAI  (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Antineoplastic Agents;Azides;Benchmarking;Benzophenones;Binding Sites;Biological;blood glucose regulation;carbene;Carrier Proteins;Cell Membrane Permeability;Cell Physiology;Cell Separation;Cell Survival;Cells;Cellular Metabolic Process;Chemical Structure;Chemicals;Chemistry;Consumption;Coupled;Cryoelectron Microscopy;Crystallography;Data;design;Development;drug candidate;drug discovery;Drug Interactions;Drug Targeting;Ensure;FASTK Gene;Free Radicals;Funding;Gases;Glucose Transporter;glucose-regulated proteins;Goals;Grant;Human;Human body;Hydrogen Bonding;hydrophilicity;Hydrophobicity;improved;innovation;Iodides;Iodine;Journals;Label;Lasers;Ligand Binding;Lipid Bilayers;lipid solubility;Lipids;Liposomes;Mass Spectrum Analysis;materials science;Membrane;Membrane Fusion;Membrane Lipids;membrane model;Membrane Proteins;Membrane Transport Proteins;Methodology;Methods;Modification;Molecular Conformation;Monitor;Motion;nanodisk;nanoparticle;non-Native;novel;Paper;Penetration;Permeability;Peroxides;Phase;physical property;Physiological Processes;Process;Protein Dynamics;Protein Footprinting;protein purification;protein structure;Proteins;Proteomics;Public Health;Publications;R24;Reaction;Reactive Oxygen Species;Reagent;reconstitution;Regulation;Reporting;Research;Resistance;Resolution;Resources;Series;Side;SLC2A1 gene;SNAP receptor;structural biology;Structure;success;Techniques;Technology;Testing;Time;titanium dioxide;tool;trafficking;Transmembrane Domain;United States National Institutes of Health

PROJECT_TITLE: NEW CHEMICAL PROBES ENABLE MASS SPECTROMETRY-BASED FOOTPRINTING OF HUMAN PROTEIN STRUCTURE IN LIPID MEMBRANES AND CELLS

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Understanding how the brain creates memories remains one of the greatest challenges in neuroscience research. The goal of this research project is to identify the cellular and network mechanisms which allow for visual recognition memory. Elucidating these mechanisms will not only provide a deeper understanding of normal brain function, but will also provide insight into disorders where visual perception, learning and memory are disrupted.

PI_NAMEs: BEAR, MARK F (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Animals;Area;area striata;autism spectrum disorder;awake;Back;Behavior;Behavioral;behavioral habituation;behavioral response;Brain;Cells;Chemosensitization;Data;density;Detection;Disabling;Electrophysiology (science);Elements;excitatory neuron;experience;experimental study;Exposure to;Failure;Familiarity;Feedback;Goals;Human;Image;Impairment;insight;interest;Interneurons;Knowledge;Laboratories;Lateral Geniculate Body;Learning;long term memory;Maintenance;Mediating;Memory;memory recognition;Mental disorders;Methods;Modeling;Modification;Molecular;Monitor;Motion;Mus;N-Methyl-D-Aspartate Receptors;Neurobiology;Neurodevelopmental Disorder;Neurons;neuropsychiatric disorder;Neurosciences;Neurosciences Research;novel;optogenetics;Parvalbumins;Pattern;Property;Punishment;rapid detection;recruit;Recurrence;Reproducibility;Research;Research Project Grants;response;Rewards;Schizophrenia;selective expression;Sensory;Site;Somatostatin;Source;Space Perception;Stimulus;Synapses;Synaptic Potentials;Testing;Thalamic structure;Time;Vision Disorders;Visual;Visual Cortex;Visual evoked cortical potential;visual memory;Visual Perception;visual stimulus;Work

PROJECT_TITLE: Behavioral Consequences and cellular substrates of plasticity in visual cortex

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]