NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Immunotherapy;Kidney Disease;Orphan Drug;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Renal cell carcinoma (RCC) is usually characterized by inactivation of the von Hippel Lindau (vHL) tumor suppressor protein, promoting accumulation of Hypoxia Inducible Factor (HIF) and consequent development of extensive vasculature, which is typically immature, lacks pericyte support, and exhibits increased permeability providing a selective therapeutic target. Vascular disrupting agents (VDAs) promise unique cancer therapy by selectively targeting these tumor-associated blood vessels, leading to rapid destruction and necrosis, and we have identified a promising new molecule, OXi8007, structurally inspired by lead VDAs (currently in clinical trials), which provides superior vessel destruction and prolonged efficacy. In combination with a new chemotherapy strategy targeting HIF-2, the recently approved thymidine kinase inhibitor cabozantinib, and potent immune checkpoint inhibitors, our studies will demonstrate enhanced therapeutic efficacy against kidney cancer to generate a translational foundation towards human applications in cancer therapy.

PI_NAMEs: LIU, LI  (contact);PINNEY, KEVIN G.

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Acute;Animals;antagonist;anti-CTLA4;anti-PD-1;Antibodies;Antigen Presentation;bHLH-PAS factor HLF;bioluminescence imaging;Blood Vessels;Cancer Patient;cancer therapy;Cell Cycle Arrest;Cells;chemotherapy;Clinic;Clinical Trials;cohort;Combined Modality Therapy;Complement;CTLA4 gene;design;Development;Disputes;Disseminated Malignant Neoplasm;Dose;Drug Combinations;early phase clinical trial;effective therapy;Endothelium;Exhibits;Foundations;Goals;Growth;Histology;Human;Hypoxia;Hypoxia Inducible Factor;image guided;immune activation;Immune checkpoint inhibitor;Immune response;Immunocompetent;Immunologic Stimulation;immunoreactivity;Immunotherapy;improved;in vivo;Infiltration;innovation;invention;Investigation;Ischemia;KDR gene;Kidney Neoplasms;kinase inhibitor;Lead;light emission;Luciferases;Macrophage;Metastatic Renal Cell Cancer;Modeling;Mus;Necrosis;Necrosis Induction;neovasculature;non-invasive imaging;novel;optoacoustic tomography;patient derived xenograft model;Patients;Pericytes;Permeability;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Prodrugs;receptor;Refractory;Renal Carcinoma;Renal Cell Carcinoma;Reporter;Reporting;Resistance;Resources;response;small molecule;success;survivorship;systemic toxicity;targeted cancer therapy;targeted treatment;Therapeutic;therapeutic target;therapy resistant;Thymidine Kinase;Toxic effect;Transfection;Translations;Treatment Efficacy;treatment response;tumor;tumor growth;tumor xenograft;Tumor-Associated Vasculature;Tyrosine Kinase Inhibitor;Up-Regulation;Vascular Permeabilities;Von Hippel-Lindau Tumor Suppressor Protein;Water

PROJECT_TITLE: Vascular image-guided optimization of response (VIGOR) to therapy in kidney cancer

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


ADMINISTERING_IC: HD

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Disability Research;Neurosciences;Patient Safety;Pediatric;Physical Rehabilitation;Rehabilitation;Unintentional Childhood Injury

ORG_CITY: CINCINNATI

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative Children requiring inpatient rehabilitation treatment following acquired brain injury (ABI) are at risk for poor engagement in rehabilitative therapies. We will use a within subject, crossover design to determine whether involving dogs in physical and occupational therapies while receiving inpatient rehabilitation improves patient engagement, how involving dogs improves engagement, and identify who is most likely to benefit. This project addresses the critical need to establish an evidence base for animal-assisted therapies in pediatric rehabilitation, incorporates innovative methods, and has the potential to lead to improved clinical care for children and adolescents receiving intensive rehabilitation following ABI.

PI_NAMEs: NARAD, MEGAN  (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Acquired disability;Address;Admission activity;Adolescent;Affect;Age;Aggressive behavior;animal-assisted therapy;Animals;Auditory;Behavior;Behavioral;Brain Injuries;Canis familiaris;Characteristics;Child;Child Care;Childhood;Clinical;clinical care;Clinical Trials;Code;Cognitive;Cross-Over Trials;Crossover Design;Data;Data Collection;design;disability;Distress;Effectiveness;efficacy evaluation;Emotional;emotional adjustment;Ensure;evidence base;facial recognition software;Family;Fatigue;Feedback;Fright;Functional impairment;functional improvement;functional status;Goals;Health;Human;Impaired cognition;improved;improved outcome;Infection;Injury;innovation;innovative technologies;Inpatients;insight;Intervention;Length of Stay;Life;Link;Literature;Measures;Mediating;Mediator;Medical;Methodology;Methods;Moods;Motivation;multidisciplinary;novel;Occupational Therapist;Occupational Therapy;Outcome;Oxytocin;Pain;Parents;Participant;Patient Admission;patient engagement;Patient Self-Report;Patients;Pediatric Brain Injury;Pediatric Hospitals;Personal Satisfaction;Physical Medicine;physical therapist;Physical therapy;Physicians;Physiological;pilot trial;Population;Positioning Attribute;positive mood;Psychologist;psychosocial outcome;Qualifying;Randomized;recruit;Rehabilitation therapy;Reporting;Research;Risk;Safety;Salivary;Sampling;Severities;social;Social Interaction;Specialist;success;Technology;Testing;Therapeutic;Time;Translating;Trauma;treatment as usual;treatment response;tumor;Videotape;Visual impairment;volunteer;Work

PROJECT_TITLE: Using Dogs to Promote Therapeutic Engagement During Inpatient Rehabilitation Following Pediatric Acquired Brain Injury: Understanding Mechanisms and Moderators of Treatment Response


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Narrative Recent findings suggest that air pollution exposure during prenatal and childhood development may be a neurotoxicant; yet questions remain as to when and how the timing of exposure impacts changes in brain structure and function across diverse populations of children. The proposed study aims to determine whether long-term and/or specific periods of exposure to air pollution, with a primary focus on fine particle matter (PM2.5), alters neurocognitive abilities of executive functions, emotional behaviors, and brain development in a large, representative nationwide cohort of youth between the ages of 9 to 12 years-old. This study has the potential to improve prevention and intervention programs to reduce cognitive and emotional problems that may otherwise persist into adult life, and its findings of how air pollution impacts brain-behavior development is important to policy markers charged with regulating air quality in urban cities.

PI_NAMEs: HERTING, MEGAN MARIE (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: 10 year old;12 year old;Address;Adolescence;Adolescent;Adult;Adverse effects;Affect;Age;Air;Air Pollutants;Air Pollution;American;Animals;Area;Behavior;Behavior assessment;behavior test;Behavioral;boys;Brain;brain behavior;brain magnetic resonance imaging;brain morphology;Carbon;Charge;Child;Childhood;Cities;Cognitive;cognitive control;cognitive development;cohort;Communities;Conflict (Psychology);Corpus striatum structure;Crime;Data;design;Development;Developmental Course;developmental neurotoxicity;Diameter;disadvantaged background;Dorsal;early adolescence;early childhood;Elements;emerging adult;Emotional;emotional behavior;Emotions;Enrollment;Environmental Risk Factor;Epidemiology;executive function;Exposure to;Family;fine particles;follow-up;Geographic Locations;Geography;girls;gray matter;Health;Heterogeneity;Human;Hybrids;improved;Individual;interest;Intervention;intervention program;Knowledge;Life;Literature;Longitudinal Studies;Maps;Methodology;Modeling;Morphology;multi-ethnic;multimodal neuroimaging;Neighborhoods;neurobehavioral;Neurocognitive;Neuroepidemiology;neuroimaging;neurotoxic;neurotoxicity;neurotoxicology;Neurotoxins;Nitrates;Nitrogen Dioxide;novel;Outcome;Outcome Measure;Ozone;parental involvement;Policies;pollutant;Population;Population Characteristics;Population Heterogeneity;preadolescence;Predisposition;Prefrontal Cortex;Pregnancy;prenatal;Prevention;Prevention program;Process;prospective;protective factors;Public Health;Recording of previous events;recruit;Regulation;resilience;Resolution;Rest;Risk Factors;Role;Sampling;Science;sex;Sex Differences;sexual dimorphism;Shapes;social adversity;Social Environment;social factors;sociodemographics;Socioeconomic Status;spatiotemporal;Structure;Sulfate;Surface;Time;tool;urban area;Violence;Visit;Vulnerable Populations;white matter;Youth

PROJECT_TITLE: Urban air pollution and neurobehavioral trajectories in the ABCD study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-K(02)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Patient Safety;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Narrative Pediatric cancer is the second leading cause of death in children, and genetic studies to inform new drug therapies have been challenging. The proposal will utilize deep learning bioinformatics methods to transfer well-established pharmacogenomics knowledge for adult cancers to the study of pediatric cancers. The findings will facilitate the optimal usage of existing drugs and the development of novel therapies for pediatric cancer, and will facilitate the candidate’s transition to an independent research career as an expert in this area.

PI_NAMEs: CHIU, YU-CHIAO  (contact)

PROGRAM_OFFICER_NAME: DUECK, HANNAH RUTH

PROJECT_TERMS: Adult;anti-cancer research;Antineoplastic Agents;Architecture;Area;Award;Bioinformatics;Biological Assay;cancer cell;Cancer cell line;cancer genome;cancer genomics;career;Cause of Death;Cells;Characteristics;Chemicals;Child;Childhood;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Computer Models;Computing Methodologies;coping;cost;Data;data resource;deep learning;deep learning model;Dependence;design;Development;Disease;drug discovery;drug sensitivity;drug testing;Educational process of instructing;Environment;experimental study;Future;gene network;Genetic;Genetic Predisposition to Disease;genetic signature;Genetic study;genome-wide;genomic profiles;genomic signature;Genomics;Grant;high dimensionality;high throughput analysis;high throughput technology;In Vitro;in vivo;innovation;insight;knockout gene;Knowledge;Learning;Machine Learning;Malignant Childhood Neoplasm;Malignant Neoplasms;Mentors;Methods;Modeling;Modernization;Molecular Profiling;Mutation;new therapeutic target;novel;novel therapeutics;patient derived xenograft model;Pattern;Pediatric Neoplasm;Performance;Pharmaceutical Preparations;Pharmacogenomics;Pharmacotherapy;Phase;Postdoctoral Fellow;pre-clinical;Preclinical Testing;predicting response;predictive modeling;programs;Publishing;Research;Research Personnel;Research Training;resistance mechanism;Resources;response;Sampling;Scheme;Seasons;skills;small molecule;Structure;Testing;Training;Training Activity;transfer learning;Translations;tumor;tumor heterogeneity;Writing

PROJECT_TITLE: Deep learning of drug sensitivity and genetic dependency of pediatric cancer cells

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Rare Diseases;Women's Health Research

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE / RELEVANCE TO PUBLIC HEALTH The proposed summer undergraduate research fellowship in the molecular biology and genomics of human cancer will offer students the opportunity to contribute to real research progress in understanding the origin, background, and treatment of gliomas, glioblastomas, leukemia, breast, bone, and ovarian cancers in the highly collaborative environment of The Jackson Laboratory for Genomic Medicine (JAX-GM). The 10-week experience will actively recruit students underrepresented in science and help plant the seeds for future diversity in the scientific, medical, and education workforces. Program alumni will be science ambassadors with a solid grounding in ethics, an appreciation for the challenges and promises of human disease research, and a zeal to share their love of science for the benefit of society.

PI_NAMEs: CHUANG, JEFFREY HSU-MIN (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: advanced analytics;analytical method;analytical tool;anti-cancer research;Area;Award;Bioethics;Bioinformatics;Biomedical Research;biomedical scientist;Cancer Biology;Cancer Center;cancer genomics;cancer immunotherapy;Cancer Research Project;career;Career Choice;career networking;Climacteric;cohort;collaborative environment;college;Communication;Communities;computerized tools;Computing Methodologies;computing resources;cost;Data;Databases;Dedications;design;Development;disadvantaged student;economic disparity;Education;education research;Educational workshop;Ensure;Environment;ethical, legal, and social implication;Ethics;Etiology;Evaluation;Evolution;experience;Faculty;faculty mentor;Feedback;Fellowship;Fellowship Program;formal learning;Foundations;Funding;Future;Genome;Genomic medicine;Genomics;Glioblastoma;Glioma;Goals;Grant;Growth;Home;Housing;Human;human disease;Immunotherapy;Individual;informal learning;innovation;Institution;instrumentation;interest;Internships;Laboratories;Leadership;Learning;leukemia;life-long learning;Love;Malignant Bone Neoplasm;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant neoplasm of ovary;Malignant Neoplasms;Medical;meetings;member;Mentors;Mission;Molecular;Molecular Biology;NCI-Designated Cancer Center;novel;Occupations;outreach;Participant;peer;Personal Growth;personalized cancer therapy;Plants;Privatization;Procedures;Process;programs;Public Health;Publications;recruit;Recruitment Activity;Research;Research Personnel;Research Project Grants;Resources;role model;Science;Scientific Inquiry;scientific literacy;Scientist;Societies;Solid;Student recruitment;Student Selections;Students;summer research;summer student;symposium;Talents;The Jackson Laboratory;Training;Transportation;Travel;undergraduate education;undergraduate research;undergraduate student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Variant

PROJECT_TITLE: Summer Undergraduate Research Fellowship in the Molecular Biology and Genomics of Human Cancer

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: DURHAM

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PUBLIC HEALTH RELEVANCE Cryo-electron tomography (cryo-ET) is an emerging imaging technique capable of elucidating the structure of proteins and protein-complexes of broad biomedical interest within the context of the cell. The development of computational methods to improve the resolution of structures determined by cryo-ET and sub-volume averaging will turn this technology into a powerful tool for studying important biomolecules in-situ. Our methods will contribute to broadening adoption of cryo-ET by adjacent disciplines in modern biology, accelerating biomedical research and providing more opportunities for the development of new medical treatments to combat disease.

PI_NAMEs: BARTESAGHI, ALBERTO  (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Acceleration;Achievement;Adoption;Algorithm Design;algorithm development;Algorithms;Benchmarking;Biological;Biology;Biomedical Research;Cells;Classification;combat;Communities;Complex;computational platform;Computer software;computerized data processing;computerized tools;Computing Methodologies;Cryo-electron tomography;Cryoelectron Microscopy;Data;Data Analyses;Data Collection;Data Set;design;Development;Discipline;Disease;Dose;Electron Microscope;Environment;Enzymes;Excision;experience;Freezing;Generations;Geometry;Goals;high resolution imaging;Hybrids;Hydration status;Image;image processing;Imaging Techniques;Imaging technology;improved;In Situ;In Vitro;innovation;interest;macromolecule;Maps;Medical;Methods;Microscopy;Modeling;Modernization;Molecular;molecular assembly/self assembly;Molecular Structure;Molecular Weight;nanometer resolution;novel;open source;Outcome;overexpression;particle;Performance;Play;Preparation;protein complex;protein structure;Proteins;prototype;public health relevance;reconstitution;reconstruction;Research;Resolution;Roentgen Rays;Role;Route;Sampling;Series;Specimen;Structure;System;Techniques;Technology;technology development;Testing;three dimensional structure;tomography;tool;Visualization;X-Ray Crystallography

PROJECT_TITLE: A Computational Platform for In-Situ Structure Determination at Near-Atomic Resolution using Cryo-Electron Tomography

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Asthma;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Endocrine Disruptors;Food Allergies;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Prevention;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narratives  This project aims to investigate the impact of early life antibody response to a broad array of pathogenic and commensal microbes and early life exposure to multiple environmental pollutants on future risk of allergic diseases. This longitudinal birth cohort study allows us to examine the temporal, dose-response, and synergistic effects of these early life factors on the development and prognosis of allergic diseases, including food allergy and asthma, from birth up to age 18 years. New knowledge gained will inform the development of novel strategies for early prediction and prevention of allergic diseases and will provide needed evidence to inform environmental standards and regulations as well as interventions to protect mothers and children from harmful environmental pollutants.

PI_NAMEs: JI, HONGKAI ;LARMAN, HARRY BENJAMIN;WANG, XIAOBIN  (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: 18 year old;Address;Adolescence;Affect;Age;age group;Air Pollution;Allergens;Allergic;Allergic Disease;analytical method;Antibodies;Antibody Repertoire;Antibody Response;Asthma;Attention;Bacterial Proteins;biobank;biological specimen archives;Birth;Black race;Blood;Boston;Cadmium;Child;Child Development;Childhood;Childhood Asthma;Clinical;Clinical Data;cohort;Cohort Studies;commensal microbes;computer infrastructure;Data;Data Element;Development;Discipline;Disease;DNA Methylation;Dose;early childhood;early life exposure;effective intervention;Enrollment;environmental allergen;Environmental Exposure;Environmental Pollutants;epidemiologic data;epigenome;Exposure to;follow-up;food allergen;Food Hypersensitivity;Funding;Future;Genetic;Genome;Goals;Growth;Health;High Prevalence;high risk;high risk population;human virome;IgE;Immune;Immune response;Immune system;Immunity;Immunoglobulin G;improved;in utero;Individual;Intervention;Knowledge;Laboratories;Lead;Life;Life Cycle Stages;Link;Literature;Low income;Measures;Mercury;metabolome;metabolomics;Microbe;Molecular;Mothers;multiple omics;Newborn Infant;novel marker;novel strategies;Outcome;pathogenic microbe;Pathway interactions;Peer Review;Perinatal;Phage ImmunoPrecipitation Sequencing;Phenotype;pollutant;Poly-fluoroalkyl substances;postnatal;predictive marker;prenatal;prenatal exposure;Prevention;Prognosis;prospective;protective factors;Proteins;Publications;Recurrence;Regulation;Reporting;Research;Resources;response;Risk;Risk Factors;Signal Transduction;software development;Staphylococcus aureus;Statistical Methods;statistics;Techniques;Technology;therapeutic target;toxic metal;toxicant;transmission process;Umbilical Cord Blood;United States National Institutes of Health;Venous;Virus;Wheezing

PROJECT_TITLE: Immune Development Across the Life Course: Integrating Exposures and Multi-Omics in the Boston Birth Cohort


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alcoholism, Alcohol Use and Health;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences;Substance Misuse

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Relevance to Public Health This project will recruit adults age 50 and older from an existing long-term study of alcohol use disorder to examine the relationship between alcohol use, aging brain function, and Alzheimer disease. This may help researchers develop treatments and ultimately reduce illness and mortality.

PI_NAMEs: HARTZ, SARAH  (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: abeta deposition;Address;Adult;Affect;African American;Age;age related;age related decline;aging brain;Alcohol consumption;alcohol effect;alcohol use disorder;Alcoholic beverage heavy drinker;Alcohols;Alleles;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid beta-Protein;Apolipoprotein E;Auditory;Blood Tests;Brain;Brain Pathology;Brain region;Clinical;Cognition;cognitive task;Communities;comorbidity;Complex;Data;Dementia;Demographic Factors;demographics;design;Development;Disease;drinking;Education;Electroencephalography;Electrophysiology (science);Environmental Risk Factor;Evaluation;Event;Family;Funding;Genes;Genetic;genetic risk factor;genetics of alcoholism;Heavy Drinking;high risk;imaging study;Impaired cognition;innovation;insight;Knowledge;Light;Longitudinal Studies;Measurement;Measures;member;mortality;National Institute on Alcohol Abuse and Alcoholism;Nerve Degeneration;neural;neural network;neuropathology;neurophysiology;Neuropsychology;neurotoxic;older adult;Onset of illness;Participant;Pattern;Phase;Plasma;polygenic risk score;pre-clinical;Process;protective factors;Psychopathology;Public Health;recruit;Research Personnel;Rest;sample collection;Sampling;Semantics;Site;Span 20;structural imaging;substance use;Surveys;Testing;Visual

PROJECT_TITLE: Investigating the longitudinal relationship between alcohol use, neurophysiological functioning, and Alzheimer disease biomarkers in the Collaborative Study on the Genetics of Alcoholism


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: Auburn

ORG_DEPT: PHARMACOLOGY

ORG_NAME: AUBURN UNIVERSITY AT AUBURN

ORG_STATE: AL

PHR: Project Narrative Tobacco-derived carcinogens can cause gain-in-function mutations in RAS genes encoding for RAS proteins that constitutively activate cellular processes responsible for multiple aspects of tumorigenesis. Because RAS is mutated during early stages of lung cancer and a well-validated, high-value, yet elusive, cancer target, we seek to further study and develop a novel class of RAS inhibitors for lung cancer chemoprevention or early treatment that has ultra-high potency and selectivity for killing lung cancer cells with mutant RAS. The proposed research will precisely define the mechanism of action, optimize oral delivery by further synthetic chemistry of analogs and prodrugs, and evaluate antitumor efficacy in mouse models of lung cancer in a comprehensive manner; all with the goals of identifying a drug development candidate for IND-enabling safety assessment and to gain insight into potential biomarkers needed to conduct clinical chemoprevention trials of individuals at risk of developing lung cancer or malignant progression.

PI_NAMEs: PIAZZA, GARY A (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Acceleration;Affect;airway epithelium;Amides;analog;Antineoplastic Agents;Apoptosis;Benchmarking;Binding;Biochemical;Biological Assay;Biological Availability;Biological Markers;cancer cell;Cancer Cell Growth;cancer chemoprevention;Cancer Patient;Carbamates;Carcinogens;Cell Cycle Arrest;cell growth;Cell Line;Cell Physiology;Cell Proliferation;Cells;Chemicals;Chemoprevention;cigarette smoke;Clinic;clinical candidate;Clinical Chemoprevention;Clinical Trials;Code;Codon Nucleotides;cohort;Derivation procedure;design;Development;Disease;drug development;Drug Kinetics;Early treatment;efficacy evaluation;Epithelial Cells;experimental study;Formulation;Future;Genes;Genetic Engineering;Goals;Growth;GTP Binding;Guanosine Triphosphate Phosphohydrolases;Histologic;Human;Hydroxyl Radical;improved;In Vitro;in vitro Model;in vivo;in vivo evaluation;Indenes;Individual;inhibitor;insight;Isoenzymes;KRAS2 gene;Lead;Libraries;Lung;lung cancer cell;Lung Neoplasms;lung tumorigenesis;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;MAP Kinase Gene;Medical;Metabolic;Modeling;Molecular Conformation;mouse model;mutant;Mutate;Mutation;Neoplasm Metastasis;neoplastic cell;Normal tissue morphology;novel;Nucleotides;Oncogenic;Oncology;Oral;Oral Administration;Pathway interactions;patient derived xenograft model;Patient Selection;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phosphoproteins;Phosphotransferases;PI3K/AKT;PIK3CG gene;potential biomarker;preclinical development;Prevention trial;Prodrugs;programs;Property;Proteins;Proto-Oncogene Proteins c-akt;prototype;RAS driven cancer;RAS genes;RAS inhibition;Ras Inhibitor;ras Proteins;Recombinants;Research;Resistance;Risk;Running;safety assessment;screening;Series;Signal Transduction;Site;small molecule;small molecule inhibitor;Solubility;Structure;Synthesis Chemistry;Testing;Therapeutic;Tobacco;translational potential;tumor;Tumor Cell Line;tumor growth;tumor progression;Tumor Promotion;Tumor Tissue;tumor xenograft;tumorigenesis;Water;Xenograft procedure

PROJECT_TITLE: Novel inhibitor for oncogenic RAS for lung cancer

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Bioengineering;Lung;Nanotechnology;Orphan Drug;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: NARRATIVE  ARDS (acute respiratory distress syndrome) is an acute, inflammatory lung disease which afflicts 190,000 Americans annually, but has no drug therapy after dozens of failed trials. To overcome these failures, we will develop a new nanotechnology, in which we package multiple drugs into 100-nanometer drug carriers that are targeted to the key cells of the alveoli (air sacs) of the lungs: endothelial cells and neutrophils. Using these targeted nanocarriers (NCs), we will answer fundamental questions in pharmacology and ARDS biology, while at the same time finding the optimal combination of cargo drugs in our NCs to create a novel therapy for ARDS.

PI_NAMEs: BRENNER, JACOB  (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Acute;Acute Respiratory Distress Syndrome;Air Sacs;Alveolar;Alveolar Cell;Alveolus;American;Antibodies;Binding;Biology;Blood;Blood capillaries;Body System;Cannulations;cell type;Cells;Clinical Trials;Combined Modality Therapy;design;Dose;Drug Carriers;Drug Combinations;Drug Delivery Systems;Drug Modulation;Drug Side Effects;Drug Targeting;Drug toxicity;Endothelial Cells;Endothelium;Failure;Functional disorder;Goals;Human;human model;Imatinib;Impairment;improved;in vivo;inflammatory lung disease;Inhalation;invention;Label;Left;Lipids;Liposomes;Liquid substance;Lung;Measures;Mediating;Mediator;Methods;Modeling;mouse model;Mus;nanocarrier;nanomedicine;nanometer;Nanotechnology;Nebulizer;neutrophil;neutrophil elastase inhibitor;novel;novel therapeutics;Organ failure;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacokinetic model;pharmacologic;Pharmacology;Pharmacotherapy;Phenotype;prevent;Publications;Publishing;Pulmonary Artery Branch;response;Role;screening;side effect;Signal Pathway;small molecule;Structure of parenchyma of lung;synergism;Testing;theories;Therapeutic;Therapeutic Effect;Therapeutic Index;Time;Tissue Banks;tool;Toxic effect;Transplantation;Treatment Efficacy;treatment optimization;uptake;Work

PROJECT_TITLE: Nanomedicine for ARDS:  A new paradigm to target drugs to multiple cell types within alveolar capillaries

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

ORG_CITY: GABORONE

ORG_COUNTRY: BOTSWANA

ORG_FIPS: BC

ORG_NAME: BOTSWANA-HARVARD AIDS INSTITUTE

PHR: Project Narrative Cross-sectional methods for identifying new infections and targeting interventions is critical, as the traditional longitudinal studies are costly. This study introduces an innovative approach to identifying recent infection which is of public health importance for both high- and low-income countries in the era of universal access to antiretroviral treatment. This mentored project will also support the development of the investigator into an independent researcher.

PI_NAMEs: MOYO, SIKHULILE  (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: 2019-nCoV;Adopted;Advisory Committees;African;AIDS prevention;Algorithms;antiretroviral therapy;Area;Bioinformatics;bioinformatics pipeline;Biological Assay;Biological Markers;Biometry;career;career development;cost;cost effective;Country;Cross-Sectional Studies;Data;Development;Development Plans;Epidemic;Epidemiology;Evaluation;Exclusion;experience;Genetic Recombination;Genome;genome sequencing;Genomics;Genotype;HIV;HIV Genome;HIV Infections;HIV-1;improved;Incidence;Individual;Infection;innovation;Institution;Intervention;Laboratories;Leadership;Length;longitudinal analysis;Longitudinal Studies;low income country;Measurement;Measures;Mentors;Mentorship;Methodology;Methods;Modeling;Molecular;Molecular Epidemiology;Monitor;next generation sequencing;Outcome;Patients;Persons;Phylogenetic Analysis;Policy Maker;Population;potential biomarker;practical application;pre-exposure prophylaxis;Prevention Research;Process;programs;prospective;Public Health;public health emergency;Research;Research Personnel;Research Project Grants;Resource-limited setting;response;RNA;Role;Sampling;scale up;screening;segregation;Sensitivity and Specificity;seroconversion;Serology;skills;Specificity;Specimen;Students;Supervision;Surveys;Testing;Time;tool;Training;Training Activity;transmission process;trend;Uncertainty;Viral;Viral Genome;Virus;Virus Replication

PROJECT_TITLE: Viral Diversity an Innovative Biomarker for Refining Estimates of HIV Incidence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-L(57)R]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Infectious Diseases;Lung;Orphan Drug;Precision Medicine;Rare Diseases;Sepsis

ORG_DEPT: ANESTHESIOLOGY

PHR: Narrative Sepsis is commonly encountered and a leading cause of in-hospital mortality. Yet, there are no specific approved therapeutic agents for sepsis. The goal of this project is to identify biologically discrete subgroups in sepsis that may differentially respond to therapies. Through a deeper understanding of these subgroups, we hope to improve patient outcomes by matching appropriate therapies to individual patients.

PI_NAMEs: SINHA, PRATIK  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Algorithms;Biological;biological heterogeneity;Biological Markers;Caring;Cessation of life;Characteristics;Classification;Clinical;clinical heterogeneity;cohort;Critical Care;Critical Illness;Cytometry;Data;Diagnosis;experience;Goals;Heterogeneity;Hospital Mortality;Immune response;Immunologics;improved;individual patient;Inflammatory;Inflammatory Response;Liquid substance;Maps;Modeling;molecular phenotype;mortality;next generation sequencing;novel;Outcome;Patient-Focused Outcomes;Patients;Peripheral Blood Mononuclear Cell;Phenotype;precision medicine;programs;Prospective cohort;Randomized, Controlled Trials;recruit;Reproducibility;Research;Resuscitation;secondary analysis;Sepsis;sepsis induced ARDS;Subgroup;Syndrome;System;targeted treatment;Techniques;Testing;Therapeutic Agents;trait;treatment effect;treatment response;trial comparing

PROJECT_TITLE: Precision Medicine in Sepsis with Critical Illness

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Primary Health Care;Suicide;Suicide Prevention

PHR: PROJECT NARRATIVE Increasing rates of suicidal thoughts and behaviors among adolescents must be addressed. The study will adapt and collect preliminary effectiveness data on a digital suicide prevention intervention that can be delivered in pediatric primary care settings by front line pediatricians. The study has the potential to offer a low-cost and scalable primary care intervention that may decrease risk of suicide among at-risk youth.

PI_NAMEs: STEPP, STEPHANIE D (contact)

PROGRAM_OFFICER_NAME: BURSTEIN, MARCY ELLEN

PROJECT_TERMS: Academy;Accident and Emergency department;Address;Adolescent;adolescent mental health;aged;American;animation;Attitude;automated text message;Behavior;Behavioral;behavioral health;Belief;Cellular Phone;Child Mental Health;Childhood;Clinical;Cognitive;Collaborations;Communication;Comprehension;computer human interaction;computerized;coping;cost;Data;Depressed mood;Depression screen;depressive symptoms;design;Development;digital;Distress;distress tolerance;Effectiveness;effectiveness testing;effectiveness/implementation trial;Emergency Situation;emotion regulation;Feedback;Feeling suicidal;Focus Groups;follow-up;Future;future implementation;Goals;Health Personnel;Health Services;high risk;Human;implementation strategy;Individual;integrated care;Intervention;intervention delivery;Intervention Studies;Interview;Medical;Mental Depression;Mental Health;Methods;Modality;National Institute of Mental Health;Online Systems;Outcome;parental involvement;Parents;Pediatric Research;pediatrician;Pediatrics;pilot trial;practice setting;practice-based research network;preference;Prevention strategy;preventive intervention;Primary Care;primary care practice;primary care provider;primary care setting;prototype;Provider;psychoeducation;Randomized;randomized trial;Recommendation;recruit;Research;Research Support;Resources;Risk;Rural;Safety;screening;service delivery;Severities;Site;skills;suburb;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide prevention;suicide rate;Survey Methodology;Surveys;Technology;Teenagers;Testing;text messaging intervention;treatment as usual;usability;wellness visit;Work;Youth

PROJECT_TITLE: Optimizing Suicide Prevention Strategies for Pediatric Primary Care


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Clinical Research;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE A class of drugs called the `anti-cancer sulfonamides' were recently discovered to work by targeting and destroying a key cellular protein called RBM39. We have recently shown that a form of blood cancer known as acute myeloid leukemia (AML), which have mutations of genes involved in RNA splicing, are particularly sensitive to these drugs; we now seek to understand more about the function of RBM39 in the normal body (including normal blood production) as well as its function in the development of blood cancers. We hope that this research will both help us understand more about how blood cancers develop, and to more intelligently optimize the anti-cancer sulfonamides to minimize side-effects from destroying RBM39 in non-cancerous cells.

PI_NAMEs: LU, SYDNEY X (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Advisory Committees;anti-cancer;Biological Assay;Blood;cancer cell;Cancer Center;cancer type;career;Cell Physiology;cell type;Cells;Clinical;Complex;conditional knockout;CRISPR screen;Custom;Data;Dependence;Development;disease model;Education;Environment;Evaluation;experience;experimental study;Faculty;functional genomics;Gene Expression;Gene Expression Regulation;Gene Mutation;Genetic;Genetic Screening;Genetic Transcription;Goals;Hematologic Neoplasms;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic Neoplasms;Hematopoietic stem cells;Human;Immunology;In Vitro;in vivo;Individual;innovation;insight;Institution;Investigation;Knockout Mice;leukemia;leukemia initiating cell;Maintenance;Malignant - descriptor;Malignant Neoplasms;Mediating;Medical Oncology;Medicine;member;Memorial Sloan-Kettering Cancer Center;Mentors;Mentorship;Modeling;Molecular;mouse model;Mus;Mutation;Myelogenous;Myeloproliferative disease;novel;novel therapeutics;Pathogenesis;Patient Care;patient derived xenograft model;patient population;Pharmaceutical Preparations;pharmacologic;Phase I/II Trial;Physicians;Physiology;Play;Privatization;Production;progenitor;programs;protein function;Proteins;Research;RNA Binding;RNA Processing;RNA Recognition Motif;RNA Splicing;RNA-Binding Proteins;Role;Safety;Scientist;side effect;skills;Somatic Mutation;Sulfonamides;tenure track;Therapeutic;therapeutic evaluation;Therapeutic Index;Tissues;Toxic effect;Training;Translations;Ubiquitin;ubiquitin ligase;Work

PROJECT_TITLE: Dissecting the Roles and Requirements for RBM39 in Acute Myeloid Leukemia and Normal Hematopoiesis

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Endocrine Disruptors;Foodborne Illness

ORG_CITY: CHAPEL HILL

ORG_DEPT: NUTRITION

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PUBLIC HEALTH RELEVANCE Environmental exposure to inorganic arsenic (iAs) is associated with risk of cancer and other deadly diseases. Laboratory mice detoxify iAs more efficiently than humans, which makes it difficult to study iAs associated diseases in laboratory settings. The goals of this project are (a) to characterize adverse effects of iAs exposure in a recently established humanized mouse strain and (b) to generate and characterize a new mouse strain, in which the role of genetic polymorphisms linked to risk of iAs-associated diseases can be studied.

PI_NAMEs: KOLLER, BEVERLY H;STYBLO, MIROSLAV  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Adrenal Glands;Adrenal hormone preparation;Adverse effects;Affect;Animal Model;Arsenic;base;behavior test;Beta Cell;biological adaptation to stress;cancer risk;Carcinogens;Cardiovascular Diseases;cohort;Complex;contaminated drinking water;design;Development;Diabetes Mellitus;diabetic;diabetogenic;Disease;disorder risk;drinking water;Drug Metabolic Detoxication;Environment;Environmental Exposure;Enzymes;Excretory function;Exposure to;Female;Food;Functional disorder;Genes;Genetic Polymorphism;Glucocorticoids;Glucose;Goals;Haplotypes;Hormones;Human;human tissue;humanized mouse;Hyperglycemia;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;impaired capacity;Impairment;improved;Insulin Resistance;Laboratories;Laboratory Animals;Laboratory mice;Laboratory Research;Laboratory Study;Link;Liver;male;Malignant Neoplasms;Mammals;metabolic phenotype;Metabolism;Methylation;Methyltransferase;Modeling;Molecular;mouse model;Mouse Strains;Mus;Nervous System Disorder;novel;Obesity;Orthologous Gene;Pattern;Phenotype;Pituitary Gland;Population;Population Study;Predisposition;Production;Public Health;public health relevance;Regulator Genes;Reporting;Research;Respiratory Disease;Risk;Role;Signal Transduction;Stress Tests;Tissues;toxicant;Toxicology;Urine;Wild Type Mouse

PROJECT_TITLE: Humanized mouse models for arsenic toxicology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-A(04)]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The US needs well-prepared scientific workforce to advance prevention and treatment strategies to combat the diabetes and obesity epidemics. The University of Utah Interdisciplinary T32 Training Program in Metabolism provides this critical training that prepares future investigators for scientific careers in the field of diabetes and obesity-related metabolic disorders. This program leverages University of Utah’s robust Diabetes and Metabolism Research Center and serves an important regional need in the Intermountain West.

PI_NAMEs: SUMMERS, SCOTT A (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Metabolism;Training Programs

PROJECT_TITLE: Interdisciplinary Training Program in Metabolism

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: ALBUQUERQUE

ORG_NAME: LOVELACE BIOMEDICAL RESEARCH INSTITUTE

ORG_STATE: NM

PHR: Narrative This project will use state-of-the-art neuroimaging tools and behavioral assessments to understand the neural signatures of attention in young children with and without prenatal alcohol exposure. The long-term goal of the project is to identify a neurophysiological marker of attention deficits to facilitate early intervention for children with prenatal alcohol exposure (PAE) as well as children with attention deficits from other causes. This study addresses the needs of children with attention deficits and their families and the NIAAA Strategic Plan calling for early identification of PAE.

PI_NAMEs: STEPHEN, JULIA MARIE (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: 7 year old;Address;Adolescent;Adult;Affect;Age;Age Years;aged;Attention;Attentional deficit;Behavior assessment;Birth;Brain;Brain region;Child;Child Support;cognitive development;cohort;Confounding Factors (Epidemiology);Data;Development;Diagnosis;Diffusion Magnetic Resonance Imaging;directed attention;Early Diagnosis;Early identification;Early Intervention;Entropy;Environment;Environmental Risk Factor;executive function;Exhibits;experience;Family;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;fetal diagnosis;first grade;Frequencies;Functional disorder;Goals;high risk;high school;Hormones;Household;improved;improved outcome;indexing;Knowledge;Life;low socioeconomic status;Magnetoencephalography;Measurable;Measures;Mediating;Modeling;National Institute on Alcohol Abuse and Alcoholism;neural;neuroimaging;neuromechanism;neurophysiology;Neuropsychological Tests;New Mexico;novel strategies;Parietal Lobe;Performance;Performance at work;Play;Positioning Attribute;potential biomarker;Poverty;pre-clinical;Prevalence;recruit;Research;Resolution;Rest;Risk;Role;Sampling;satisfaction;Schools;sex;sex as a biological variable;social relationships;Socioeconomic Status;socioeconomics;Source;Strategic Planning;Targeted Research;Testing;Thalamic structure;therapy development;tool;white matter

PROJECT_TITLE: Attending to all children: Examining the role of alpha oscillations in attention in young children with and without prenatal alcohol exposure (AsCENd)

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: BIRMINGHAM

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

PHR: PROJECT NARRATIVE Anti-cancer therapeutics targeting the adaptive immune response, including checkpoint blockade, have been a boon for a subset of patients and are being combined with chemotherapy to further improve outcomes. We have identified an innate immune checkpoint utilized by tumor cells to suppress the anti-tumor response during chemotherapy and, based on our mechanistic understanding, have discovered a combination therapy (PTP1b inhibition/chemotherapy) that improves survival in multiple preclinical models. We propose to 1) determine whether this immune suppressive mechanism is predictive of patient response to chemotherapy, 2) identify which chemotherapies yield the most robust response in conjunction with PTP1b inhibition and 3) understand how our therapeutic affects the adaptive immune response and responsiveness to checkpoint blockade.

PI_NAMEs: UBIL, ERIC S (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: adaptive immune response;Adaptor Signaling Protein;Advanced Malignant Neoplasm;Affect;Agonist;anti-cancer therapeutic;anti-tumor immune response;Antitumor Response;Binding;Binding Proteins;Cancer Patient;Career Transition Award;Cause of Death;Cell Communication;Cell Death;Characteristics;checkpoint therapy;Chemoresistance;chemotherapy;Clinical Trials;Combined Modality Therapy;Complex;CTLA4 gene;Diagnosis;efficacy evaluation;Genetic;Human;Immune;immune activation;immune cell infiltrate;immune checkpoint;immune checkpoint blockade;Immune response;Immune Targeting;immunogenic;Immunosuppression;Immunotherapy;improved;improved outcome;In Vitro;in vivo;Inflammatory;Inflammatory Response;inhibitor;innate immune checkpoint;Innate Immune Response;Interferon Type II;Ligands;Macrophage;Macrophage Activation;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Melanoma;Modeling;Molecular;mouse model;Mus;MyD88 protein;neoantigens;neoplastic cell;novel;Nuclear Translocation;patient response;patient subsets;Patient-Focused Outcomes;Patients;Pattern;pharmacologic;Phosphoric Monoester Hydrolases;Phosphorylation;Pre-Clinical Model;prevent;Process;Prognosis;programmed cell death ligand 1;programmed cell death protein 1;Protein S;Proteins;receptor;Receptor Activation;Receptor Signaling;Relapse;response;screening;Signal Transduction;success;T cell response;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapeutic target;Time;Toll-like receptors;treatment response;tumor;tumor growth;Tumor-Derived;Tumor-infiltrating immune cells;Tumor-Secreted Protein;United States

PROJECT_TITLE: PTP1b Inhibition Restores the Innate Anti-tumor Response During Chemotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-D(08)F]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Suboptimal linkage to and retention in HIV prevention and care is prevalent among high risk women who use or inject drugs in both the US and globally, including high HIV incidence contexts like Kazakhstan; addressing HIV and intersectional stigma, especially from health care providers (HCP) within clinics, is necessary to increase engagement in the HIV care and prevention continuum. To address this challenge and increase HIV prevention and care, the proposed study will involve the design and assessment of the acceptability, feasibility, and usability of a three component, multi-level participatory intervention to promote stigma resistance/coping and reduce anticipated/internalized stigma among high risk women who use drugs as well as to reduce enacted stigma among HCP in Kazakhstan, Central Asia. Results of this study will generate information in order to power a future preliminary effectiveness trial and will be unique in utilizing multilevel anti-stigma approaches for both high risk women who use drugs and HCP, all of which will have important implications for advancing HIV prevention and care engagement among highly stigmatized populations in diverse settings.

PI_NAMEs: FRYE, VICTORIA ;WEST, BROOKE S. (contact)

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;Advocacy;AIDS prevention;antiretroviral therapy;Appointment;arm;Attitude;Awareness;Belief;Caring;Central Asia;Cessation of life;Client;Clinic;Communicable Diseases;Communities;Continuity of Patient Care;coping;Country;crowdsourcing;Data;Dermatology;design;Drug usage;Drug user;effectiveness trial;evidence base;experience;female sex worker;Focus Groups;follow-up;Future;Goals;health assessment;health goals;Health Personnel;Healthcare;High Risk Woman;HIV;HIV Infections;HIV/STD;Human immunodeficiency virus test;improved;Incidence;Income;Infection;Injecting drug user;innovation;internalized stigma;Intervention;Kazakhstan;low and middle-income countries;Media Campaign;Methods;Multimedia;Online Systems;Outcome;Persons;Pharmaceutical Preparations;pilot test;Population;Population Intervention;post implementation;pre-exposure prophylaxis;Prevalence;Prevention;primary outcome;Provider;Public Health;Research;Research Infrastructure;resilience;Resistance;Resources;response;Risk;secondary outcome;self testing;sex;Sex Discrimination;Sexual Health;Sexual Partners;social stigma;Source;stem;Stereotyping;Stigmatization;success;Testing;therapy design;Training;Training Programs;uptake;usability;Viral;Visit;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Reducing Intersectional and HIV Stigma among High Risk Women who use Drugs in Kazakhstan, Central Asia: A Multilevel Stigma Resistance and Enacted Stigma Reduction Intervention for Women and Providers

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: MD

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: College Station

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

ORG_STATE: TX

PHR: Project Narrative One in three youth in the United States are overweight, and nearly 85% of overweight youth have at least one  Metabolic Syndrome (MetS) risk factor that is affected by their school physical activity and food environments,  as well as their engagement in physical activity and healthy eating behaviors. Strong Teens for Healthy Schools  Change Club (STHS-CC) is a multi-level, theory-based civic engagement program that equips and supports  middle school students in racially/ethnically diverse, Title 1 middle schools to make a positive food and  physical activity environmental change and personally engage in physical activity and healthy eating behaviors  to reduce their MetS risk. Working in partnership with Cooperative Extension and 4-H staff, school educators,  and middle school students, we will refine the STHS-CC curriculum for delivery and use a cluster randomized  controlled trial to evaluate the effectiveness of the intervention for improving individual (i.e., MetS risk,  positive youth development), social (i.e. peer support and engagement in health behaviors), and environmental  (i.e., school physical activity and nutrition environments) outcomes, as compared to students in the control  condition.

PI_NAMEs: MACMILLAN URIBE, ALEXANDRA L;SZESZULSKI, JACOB  (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Address;Administrator;Adolescence;Adult;Advisory Committees;Affect;Behavior;Cardiovascular Diseases;cardiovascular disorder risk;Caring;catalyst;Child;Collection;Communities;community advisory board;community engagement;Competence;Consumption;Data Analyses;Development;dietary;Disease Outcome;Eating Behavior;Educational Curriculum;effective intervention;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;empowerment;Environment;environmental change;ethnic diversity;evidence base;Evidence based intervention;Focus Groups;Food;food environment;Fostering;fruits and vegetables;Funding;Goals;Health;Health behavior;Health behavior and outcomes;Health Food;Health Policy;Health Promotion;Healthy Eating;healthy weight;improved;Individual;Intervention;Interview;junior high school;Leadership;Life Cycle Stages;low socioeconomic status;Metabolic syndrome;Middle School Student;Modeling;Neighborhoods;novel;nutrition;obesity prevention;Outcome;Overweight;Participant;Pattern;peer;peer support;Physical activity;Play;Policies;Population;positive youth development;post intervention;Prevalence;Preventive service;Process;programs;racial diversity;Randomized, Controlled Trials;Recommendation;Risk;Risk Factors;Role;Rural Community;rural underserved;school health;Schools;seventh grade;sixth grade;skills;social;Socioeconomic Status;Students;teacher;Teenagers;Testing;theories;United States;United States National Institutes of Health;Weight;Youth

PROJECT_TITLE: Strong Teens for Healthy Schools Change Club: A civic engagement approach to improving physical activity and healthy eating environments


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Genetics;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: MAYWOOD

ORG_DEPT: PHYSIOLOGY

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Binge-pattern alcohol consumption during adolescence can result in lifelong neurobiological consequences including anxiety, major depression, and addiction. These studies will establish the molecular changes induced by alcohol that predisposes the neuronal environment to perpetuate these changes into adulthood.

PI_NAMEs: PAK, TONI R. (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Abstinence;addiction;Adolescence;Adolescent;adolescent alcohol abuse;adolescent binge drinking;Adult;Alcohol abuse;Alcohol consumption;Alcohols;Alternative Splicing;Amino Acid Receptors;Amino Acids;Animal Model;Animals;Anxiety;Behavior;Behavioral;Binding;binge drinking;Brain;Cell Physiology;Cells;Cellular Stress;chromatin immunoprecipitation;Corticosterone;cost;Data;depressive symptoms;Disease;EMSA;Environment;Ethanol;experimental study;Exposure to;Functional disorder;Funding;Genes;Genomics;Glucocorticoid Receptor;glucocorticoid-induced orphan receptor;Glucocorticoids;Goals;Homeostasis;Immunoprecipitation;in vivo Model;Inflammatory;inhibitor;Knowledge;Label;Life;Ligands;Link;Long-Term Effects;Major Depressive Disorder;Mass Spectrum Analysis;Measures;Mediating;Mediator;Mental disorders;Messenger RNA;Modeling;Modification;Molecular;Nervous System Trauma;Neurobiology;Neurons;new therapeutic target;novel;offspring;Pattern;Phase;Phosphorylation;Physiological;Pituitary-Adrenal System;Post-Translational Protein Processing;prevent;Process;promoter;protein protein interaction;Proteins;Proteome;Proteomics;Publishing;receptor;receptor function;Receptor Signaling;Receptor-Interacting Protein;Reporting;Research;Resistance;RNA;RNA Splicing;Signal Transduction;Stress;Structure;Testing;Time;transcription factor;Transcription Process;Transcription Repressor;transcriptome;Translation Process;United States Substance Abuse and Mental Health Services Administration;university student;Variant;Youth

PROJECT_TITLE: Neuromolecular consequences of adolescent binge drinking

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Emergency Care;Health Services;Hematology;Infectious Diseases;Lung;Patient Safety;Rare Diseases;Sepsis

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: Project Narrative Since the introduction of sepsis bundles, there have been multiple published trials that have demonstrated a consistent, strong association between implementation of sepsis “bundles” (3- hour bundle) and improved survival. The current proposal is a Hybrid 2, pragmatic, cluster randomized clinical effectiveness/implementation trial evaluating mortality and respiratory failure-based outcomes, in patients admitted to the emergency department with sepsis, comparing the effectiveness of implementation of the hour-1 bundle to 3-hour bundle, while facilitatingadherence to both bundles. In addition, 4 distinct sepsis phenotypes will be derived from routine clinical data to identify specific patient phenotypes that allow for a more precision-based application of sepsis bundles in future studies.

PI_NAMEs: LEVY, MITCHELL M (contact)

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: Academic Detailing;Accident and Emergency department;Acute respiratory failure;Address;Adherence;Admission activity;Adoption;arm;Caring;Cessation of life;Characteristics;Climate;Clinical;Clinical Data;Clinical effectiveness;clinical phenotype;clinical practice;Cluster randomized trial;cohort;Communities;comparative effectiveness;compare effectiveness;Critical Care;Data;Databases;Death Rate;Education;Effectiveness;effectiveness evaluation;effectiveness outcome;effectiveness/implementation hybrid;effectiveness/implementation trial;Electronic Health Record;Elements;Emergency Department patient;Enrollment;Evaluation;evidence base;experience;Future;Goals;Guidelines;Heterogeneity;Hospital Mortality;Hospitals;Hour;Hybrids;implementation evaluation;implementation facilitation;implementation facilitators;implementation intervention;implementation process;implementation science;implementation strategy;implementation/effectiveness;improved;improved outcome;Incidence;individualized medicine;Infection;Intensive Care Units;Intervention;Interview;Leadership;Learning;Length of Stay;Link;Liquid substance;Lung;Measures;Mechanical ventilation;Mediating;Medicine;meetings;Methods;Modeling;mortality;Multicenter Trials;New York;novel;Observational Study;organizational readiness;Outcome;Outcome Measure;Patient Admission;Patient Care;Patient-Focused Outcomes;Patients;Performance;Phase;Phenotype;Population Heterogeneity;pragmatic trial;precision medicine;Preparation;primary outcome;programs;Publishing;Randomized;randomized trial;randomized, clinical trials;Relative Risks;Reporting;Research;respiratory;Respiratory Disease;Respiratory Failure;Respiratory Tract Infections;response;Resuscitation;Risk Reduction;Screening procedure;secondary outcome;Sepsis;septic patients;Septic Shock;Societies;Source;standard of care;Structure;Surveys;treatment effect;United States;United States Centers for Medicare and Medicaid Services;uptake;Ventilator;Work

PROJECT_TITLE: Assessment of Implementation Methods in Sepsis and Respiratory Failure

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome;Precision Medicine

PHR: PROJECT NARRATIVE Heart failure (HF) afflicts 6.5 million US adults and is associated with significant morbidity, mortality (50% at five years of diagnosis), and expense for healthcare systems worldwide. Recovery of cardiac function has been reported in ~15% of patients with end-stage HF. Understanding the factors and mechanisms associated with cardiac recovery could lead to the development of novel personalized therapies to improve outcomes in the broad HF population.

PI_NAMEs: WEVER-PINZON, OMAR ENRIQUE (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Acceleration;Adult;advanced disease;Affect;Apical;Area;ASCL1 gene;Back;base;bench to bedside;Binding;Bioinformatics;Biological;bisulfite sequencing;Candidate Disease Gene;candidate identification;Cardiac;Cardiovascular system;career;Characteristics;Chronic;Clinical;Clinical Data;Clinical Investigator;clinical predictors;clinically relevant;Data;design;Development;Devices;Diagnosis;Disease;Disease Progression;DNA Methylation;DNA Methylation Regulation;DNMT3a;Epigenetic Process;epigenomics;exceptional responders;experience;Foundations;Gene Expression;gene function;Gene set enrichment analysis;Genes;Genetic;Genetic Transcription;genome sequencing;genomic data;genomic locus;Genomics;Glycolysis;Goals;Healthcare Systems;Heart;Heart failure;heart function;heart metabolism;hemodynamics;Image;implantation;improved;improved outcome;insight;K-Series Research Career Programs;left ventricular assist device;Malignant Neoplasms;Mentors;Messenger RNA;Methods;Methylation;Modeling;Modification;Molecular;Molecular Analysis;Morbidity - disease rate;mortality;multidisciplinary;Myocardial;Myocardium;new technology;new therapeutic target;novel;novel strategies;novel therapeutics;Output;Oxidative Phosphorylation;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;personalized approach;personalized medicine;Population;Positioning Attribute;predictive modeling;programs;Promoter Regions;Publications;rational design;Recovery;Regulation;Reporting;Research;Research Personnel;Research Training;responders and non-responders;Role;Sampling;Severities;skills;sound;Standardization;Study models;targeted treatment;Testing;Time;Tissues;Training;Transcriptional Regulation;transcriptome sequencing;Translational Research;translational study;Treatment Failure;whole genome;Work

PROJECT_TITLE: Role of DNA methylation in cardiac failure and recovery

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Methamphetamine;Neurosciences;Opioid Misuse and Addiction;Opioids;Prevention;Stimulant Use and Misuse;Substance Misuse

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Project Narrative  Access to social interaction has protective and restorative effects in animal models of opioid craving. By using a novel rat model of choice between social interaction and heroin in combination with cutting-edge molecular approaches, this proposal will determine the genomic network mediating the protective effect of social interaction on heroin craving. We anticipate our results to have a translational impact by identifying distinct genetical markers that may inspire clinical studies to determine whether social-based behavioral treatments would restore physiological circuitry function, resulting in reduced long-term relapse risk.

PI_NAMEs: AMENT, SETH ABRAMS;LOBO, MARY KAY ;VENNIRO, MARCO  (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Abstinence;addiction;Alternative Therapies;Amygdaloid structure;Animal Model;Anterior;Autopsy;Behavior;Behavior Therapy;BRAIN initiative;Brain region;Buffers;Buprenorphine;Cell Nucleus;cell type;Cells;Censuses;Clinical;Clinical Research;Cocaine;Communities;Complex;craving;CRISPR interference;CRISPR-mediated transcriptional activation;Cues;Data;Dependovirus;Dorsal;drug abstinence;Drug Addiction;drug craving;Drug Modelings;drug reward;DSM-IV;Gene Expression;Genes;Genetic;Genetic Markers;Genetic Transcription;genomic profiling;Genomics;Goals;Heroin;HIV;Home;Human;Immunohistochemistry;improved;Incubated;insight;Insula of Reil;Label;large datasets;Lateral;Literature;Measures;Mediating;Messenger RNA;Methadone;Methamphetamine;model design;Modeling;Molecular;Naltrexone;neural;Neurons;novel;Ontology;Opiate Addiction;Opioid;opioid epidemic;opioid use disorder;overdose risk;Patients;peer;Pharmaceutical Preparations;Physiological;prevent;Procedures;professional atmosphere;protective effect;Psychological reinforcement;psychostimulant;Public Health;Rattus;recruit;reinforcer;Relapse;relapse risk;Research;response;Rewards;Rodent;Role;Self Administration;single nucleus RNA-sequencing;social;social factors;Social Interaction;Somatostatin;Stimulus;Stress;Structure of paraventricular nucleus of thalamus;success;Support Groups;Testing;Time;tool;transcriptomics;Translating;translational approach;translational impact;United States Food and Drug Administration;Virus;Withdrawal

PROJECT_TITLE: Genomic profiling mediating the protective effect of social reward on opioid craving


NIH_SPENDING_CATS: Clinical Research;Lung;Microbiome;Neonatal Respiratory Distress;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Pulmonary Fibrosis;Rare Diseases

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE Bronchopulmonary dysplasia, a devastating chronic lung disease with debilitating long-term consequences, affects approximately half of all infants born extremely preterm. The objectives of this proposal are relevant to public health because they aim to establish that bacterial communities in the gut influence development of bronchopulmonary dysplasia by altering the immune responses of the developing lung. Successful completion of this proposal will provide insight into extra-pulmonary contributions to lung development and characterize new targets for therapy, which addresses goals of the NIH to seek mechanistic understanding of the microbiome in the pathobiology of lung diseases and reduce the incidence of chronic lung disease during early life.

PI_NAMEs: WILLIS, KENT AVERY (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Acceleration;acrosome stabilizing factor;Address;Affect;Alabama;Antibiotics;Asthma;bacterial community;Blood Vessels;Bronchopulmonary Dysplasia;career development;Cell Wall;Chronic lung disease;Clinical Research;commensal bacteria;Communities;Complication;critical developmental period;density;design;Development;Development Plans;Ecology;Education;epidemiology study;Exhibits;experience;Exposure to;extreme prematurity;Feces;fungus;Germ-Free;Gnotobiotic;Goals;gut microbiome;gut microbiota;gut-lung axis;Health;Human;Hyperoxia;Immune response;Immune system;Immunologic Stimulation;Immunologics;Immunology;improved;Incidence;Infant;Inflammation;innovation;insight;interstitial;Intestines;Knowledge;Life;Link;Long-Term Effects;Lung;lung development;Lung Diseases;lung injury;Lymphoid Cell;Machine Learning;member;Mentors;Mentorship;microbial community;microbiome;microbiome alteration;microbiome components;microbiome composition;Modeling;Molecular;Morphology;mortality;mouse model;Mucosal Immune Responses;Mucous Membrane;Mus;mycobiome;Neonatal;neonatal lung disease;neonatal mice;neonatal period;neonate;new therapeutic target;Newborn Infant;Pediatrics;Perinatal;Phenotype;Play;Pneumonia;pneumonia model;Population;pre-clinical;Pregnancy;Premature Birth;prenatal;preterm newborn;Prevention;Productivity;professor;Program Development;protective effect;Public Health;Pulmonary Fibrosis;pulmonary function;Pulmonary Inflammation;Recording of previous events;Research;research and development;Research Methodology;respiratory microbiome;Risk;Risk Factors;Role;Scientist;screening;Severities;Severity of illness;Shapes;skills;Specificity;standard of care;Structure;Testing;The science of Mycology;Therapeutic;therapeutic development;therapeutic target;Time;Training;translational research program;translational study;United States National Institutes of Health;Universities

PROJECT_TITLE: The gut-lung axis influences the development of bronchopulmonary dysplasia

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE This project will pair the NIH-funded AAV BRAIN Safe and Effective Neuromodulator and Sensor Utilization across Species (SENSUS, led by Caltech) with California State Polytechnic University, Pomona (CPP) to build a new Armamentarium Vector Core (ArmVC), broadening the Armamentarium project’s ability to validate and disseminate the next generation of modern gene delivery tools to understand and, eventually, treat the brain. In addition, ArmVC will help to build a new, more diverse brain gene therapy workforce through the AAV BRAIN SENSUS Program for Integrated Research Experiences (ASPIRE). As ASPIRE Scientists, undergraduates from CPP—a designated Hispanic-Serving Institution that also serves a large number of Pell-eligible, first-generation, and African American students—will receive extensive training and mentoring both at Caltech and CPP while broadening novel AAV validation, production, and dissemination through ArmVC.

PI_NAMEs: GRADINARU, VIVIANA ;SHAY, TIMOTHY FRANCIS (contact)

PROGRAM_OFFICER_NAME: KIM, DOUGLAS SUN-IL

PROJECT_TERMS: adeno-associated viral vector;Adopted;African American student;aluminum sulfate;Biological;Biological Assay;Biotechnology;Brain;BRAIN initiative;California;Capsid;career;Cataloging;Cell Culture Techniques;cell type;Collaborations;Communities;Custom;Dedications;Dependovirus;Disease;Diverse Workforce;Dose;Ecosystem;Education;Educational workshop;Electronics;Eligibility Determination;Engineering;Ensure;Equipment and supply inventories;Equity;experience;Feedback;Fees;Fostering;Freezing;Funding;Gene Delivery;gene therapy;Generations;Genome;Hispanic-serving Institution;Human;Immunohistochemistry;Infrastructure;Injections;innovation;instrumentation;Link;Mammalian Cell;meetings;Mentors;Methodology;Methods;Minority-Serving Institution;Mission;Modernization;Molecular;Monitor;Mus;Neuromodulator;Neurons;Neurosciences;next generation;novel;Population;posters;pre-doctoral;Process;Production;programs;Publications;quality assurance;Quality Control;Reagent;Research;Research Personnel;Resources;Running;Science;science and society;Scientist;sensor;sex;Site;Structure;Students;summer program;Support System;System;tool;Training;Tropism;undergraduate research;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Universities;Validation;vector;Virus;virus identification;web site;Work

PROJECT_TITLE: Broadening access with an Armamentarium Vector Core Powered by Inclusive Research Experiences


ORG_DEPT: SURGERY

PHR: Narrative This proposal will determine how changing mechanical load, such as occurs when the heart has to pump against a high pressure, influences structures of the heart muscle membrane called transverse tubules. These (t)-tubules are disrupted in diseases such as heart failure, but how changing the load of the heart affects them is not known. Understanding this process, and the molecules responsible, might help in discovering new treatments for heart failure.

PI_NAMEs: IBRAHIM, MICHAEL  (contact)

PROJECT_TERMS: Address;adenoviral mediated;Adenovirus Vector;Adult;Affect;Architecture;Binding;Biomechanics;Biomimetics;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiovascular system;career;Cells;Cellular biology;Chronic Disease;Coupling;Custom;Disease;Dissection;elastomeric;Elastomers;Electrophysiology (science);Event;experimental study;flexibility;gain of function;genetic manipulation;Heart;heart defect;Heart failure;Hour;Human;Impairment;improved;In Vitro;in vivo;insight;junctophilin;Length;live cell imaging;Location;loss of function;Maps;mechanical load;Mechanics;Mediating;Mediator;Membrane;Mentors;Mentorship;Methodology;Methods;Microtubules;Modeling;Molecular;Muscle;Myocardial;Myocardium;Nature;novel;overexpression;Pathologic;Pathway interactions;Phenotype;post-doctoral training;Preparation;preservation;pressure;Process;Proteins;Protocols documentation;Pump;Rattus;Regulation;Research;response;Rodent;Role;Ryanodine Receptor Calcium Release Channel;Scientist;Slice;Stress;Structure;superresolution imaging;superresolution microscopy;Surgeon;System;targeted treatment;Techniques;Testing;Thoracic aorta;Time;tool;Training;Variant;Viral Vector;Work

PROJECT_TITLE: Molecular mechanisms of load-induced t-tubule regulation in the mammalian heart

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(JA)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Hearing Loss;Neurosciences;Regenerative Medicine

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF MISSOURI KANSAS CITY

PHR: Public Health Relevance/Project Narrative A large proportion of the world’s population will experience hearing loss at some point in their lifetime, often as a result of external causes. The sensory cells of the inner ear, called hair cells, are very sensitive to damage, and in mammals, once these cells are lost, they will not regrow. In this proposal, we will use zebrafish as a model organism to define the genetic pathways that regulate sensory hair cell regeneration, with the long-term goal of providing a mechanism to regrow sensory hair cells in the human inner ear.

PI_NAMEs: MCGRAW, HILLARY FAYE (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: Adult;Affect;Age;Biological Models;Cell Differentiation process;cell injury;Cell Proliferation;Cell Survival;Cells;Cellular biology;Cellular Morphology;Cochlea;Data;Defect;Development;Disease;equilibration disorder;Equilibrium;Esthesia;experience;experimental study;Exposure to;Family;Fishes;Force of Gravity;FOXG1B gene;gene function;Generations;Genes;Genetic;genetic manipulation;Genetic Transcription;Goals;hair cell regeneration;Hair Cells;hair regeneration;Hearing;hearing impairment;hearing loss treatment;Human;inhibitor;Injury;Inner Hair Cells;Labyrinth;lateral line;Ligand Binding;Mammals;Mediating;model organism;Modeling;Molecular;mutant;Mutation;Natural regeneration;Neomycin;Neonatal;neonatal mice;Noise;noise exposure;ototoxicity;Outcome;Pathway interactions;permanent hearing loss;Pharmaceutical Preparations;pharmacologic;Population;Proliferating;Proteins;public health relevance;Quality of life;receptor;regenerative;Research;response;Role;Sensory;Sensory Hair;stem cells;Supporting Cell;System;targeted treatment;Testing;Touch sensation;transcription factor;Transcriptional Activation;Vertebrates;vestibular system;Water;WNT Signaling Pathway;Work;Zebrafish;zebrafish development

PROJECT_TITLE: Wnt pathway mutations alter hair cell regeneration in the zebrafish fish lateral line


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Post-Traumatic Stress Disorder (PTSD);Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Racism continues to plague minority sub-groups in the United States, and race-related stress (RRS) contributes to health disparities among African Americans (AA) with alcohol use disorder (AUD); however racial identity (RI) may buffer this effect. It is crucial to understand how RRS influences alcohol use and risk for developing AUD in order to identify targets for interventions that are culturally salient for AA. Serving toward Dr. Brown’s ultimate career goal of becoming an independent investigator in the alcohol field focused on health disparities, she will address this gap in the literature by using a human laboratory paradigm and ecological momentary assessment (EMA) methods to examine the effects of RRS on reactivity to cue- induced stress and craving and the role of RI among AA with current AUD.

PI_NAMEs: BROWN, DELISA  (contact)

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: Address;Affect;African American;African American population;alcohol abuse therapy;Alcohol consumption;alcohol craving;alcohol related problem;alcohol research;alcohol risk;alcohol use disorder;alcohol use initiation;Alcohols;Applications Grants;Area;avoidance behavior;Back;binge drinking;Biological;biological adaptation to stress;Buffers;career;career development;Chronic;Clinical Trials;Collaborations;comorbidity;Competence;Consumption;craving;Cues;culturally appropriate intervention;Data;Data Analyses;Data Collection;design;Development;Diabetes Mellitus;Dimensions;Disease;Distress;Dreams;drinking;drinking behavior;Ecological momentary assessment;Empirical Research;Ensure;ethnic health disparity;ethnic minority;Ethnic Population;evidence base;Evidence based treatment;Exhibits;experience;Exposure to;Frequencies;Functional disorder;Future;Galvanic Skin Response;Goals;Grant;health disparity;health disparity populations;Heart Rate;Human;Hydrocortisone;Imagery;Incidence;insight;Intervention;Knowledge;Knowledge acquisition;Label;Laboratories;Legal;Link;Literature;Maintenance;Manuals;Manuscripts;Medical;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;Methods;Minority;minority disparity;Minority Groups;minority health;minority health disparity;Mission;National Institute on Alcohol Abuse and Alcoholism;Nature;negative affect;Neurosecretory Systems;novel;Obesity;Outcome;patient oriented;Pattern;physical conditioning;Physiological;Post-Traumatic Stress Disorders;Productivity;Protocols documentation;Race;racial health disparity;racial identity;racial minority;racial population;racism;Recording of previous events;Relapse;Reporting;Research;research and development;Research Personnel;Risk;Role;Science;Scientist;Series;Site;skills;social;social health determinants;Stress;stressor;Stroke;Subgroup;symposium;Symptoms;therapy development;Time;Training;Training Activity;Trauma;traumatic stress;United States;Universities;Writing

PROJECT_TITLE: Identifying the Effects of Race-Related Stressors on Laboratory- Induced Stress and Craving among African Americans with Alcohol Use Disorder

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: This study will develop small molecule inhibitors, which we have selected to block the interaction between MDM2 protein and XIAP IRES mRNA, as novel drugs that can suppress or kill tumor cells through targeting the tumor-associated expression of both MDM2 and XIAP.

PI_NAMEs: LI, WEI  (contact);ZHOU, MUXIANG

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: analog;anti-cancer;anti-cancer treatment;Antibodies;anticancer activity;Apoptosis;Apoptotic;Back;Binding;Biological;Biological Assay;Biotechnology;BIRC4 gene;C-terminal;Calorimetry;cancer cell;cancer drug resistance;cancer therapy;cancer type;Cell Line;Cell Survival;Cessation of life;Clinical;Complex;Computer Assisted;CRISPR/Cas technology;design;Disease Progression;Down-Regulation;Drug Design;Drug Kinetics;Drug resistance;efficacy study;Evaluation;Fluorescence Polarization;Genes;genome editing;Goals;high throughput screening;Human;immunodeficiency;in vivo;Induction of Apoptosis;inhibitor;Internal Ribosome Entry Site;Knock-out;leukemia;Leukemic Cell;Malignant Neoplasms;MDM2 gene;Measurement;Messenger RNA;meter;Molecular;Molecular Biology;molecular modeling;mouse model;Mus;neoplastic cell;Neuroblastoma;neuroblastoma cell;Normal Cell;novel;novel therapeutics;Oncoproteins;overexpression;Pharmaceutical Chemistry;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Play;preclinical evaluation;preclinical study;Property;Proteins;Publishing;Resistance development;Roentgen Rays;Role;scaffold;SCID Mice;small molecule inhibitor;small molecule libraries;structural biology;Structure;Structure-Activity Relationship;Surface Plasmon Resonance;targeted agent;targeted treatment;Testing;Therapeutic;Tissues;Titrations;Toxic effect;TP53 gene;Transfection;Translations;Treatment outcome;tumor;tumor progression

PROJECT_TITLE: Dual inhibition of MDM2 and XIAP as a therapeutic strategy in cancer

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Prevention

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Comprehensive analysis of the genomes of cancer cells is transforming our approach to the prevention, diagnosis, and treatment of cancer. To date, however, the cancer genomics revolution has largely ignored tumors from patients in Africa and has not involved many African scientists. The training program in this application aims to provide graduate level training in cancer genomics and genomic data science to students in Uganda and East Africa to prepare them to bring the benefit of the cancer genomics revolution to Africa.

PI_NAMEs: OREM, JACKSON ;WARREN, EDUS HOUSTON (contact)

PROGRAM_OFFICER_NAME: SIVARAM, SUDHA

PROJECT_TERMS: Acceleration;Address;Advanced Malignant Neoplasm;Africa;African;anti-cancer research;Bioinformatics;cancer genome;cancer genomics;Cancer Patient;cancer therapy;clinical care;Collaborations;college;Communicable Diseases;Communities;Data;Data Science;Dedications;Development;Diagnosis;Doctor's Degree;Ensure;Fred Hutchinson Cancer Research Center;Generations;Genetic Variation;Genome;genomic data;Genomics;Health Sciences;Home;Human Genetics;Human Genome;improved;Individual;Infrastructure;Institution;Malignant Neoplasms;Master of Science;Patients;Prevention;Prevention approach;programs;Publications;Reproducibility;Research;Scientist;The Cancer Genome Atlas;Training;tumor;Uganda;Universities;whole genome

PROJECT_TITLE: Cancer Genomics and Genomic Data Science for East Africa


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Neurosciences;Precision Medicine;Rare Diseases

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Pre-analytical processing of biological samples profoundly impacts data output in research and clinical settings. And yet, the relative effects of variables associated with tissue collection, preservation, transport, storage, sampling and analytic processing on the reliability of epigenetic biomarkers in cancer studies – including the uniformly lethal brain tumor glioblastoma – have not been rigorously examined. This proposal addresses the need to define pre-analytical variables in the clinically used glioblastoma MGMT promoter methylation biomarker assay.

PI_NAMEs: BOMSZTYK, KAROL  (contact);ROSTOMILY, ROBERT C

PROGRAM_OFFICER_NAME: RAO, ABHI

PROJECT_TERMS: Address;Affect;Biological;Biological Assay;Biological Markers;biomarker discovery;Brain Neoplasms;cancer biomarkers;chemical fixation;Chromatin;Clinical;Clinical Management;clinically relevant;CryoCore Gun;Cryopreservation;Data;Deamination;Devices;Disease;DNA;DNA Methylation;DNA Repair Enzymes;Eosine Yellowish;epigenetic marker;Epigenetic Process;evidence base;Excision;Formalin;Freezing;Genetic Transcription;Glioblastoma;Goals;Histologic;Histology;Histopathology;Ice;Immunoprecipitation;Individual;Institution;Ischemia;Knowledge;Laboratories;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;Methods;Methylation;methylation biomarker;MGMT gene;Modification;multidisciplinary;neuropathology;novel;Output;Paraffin Embedding;Patients;personalized medicine;Preparation;preservation;Procedures;Process;prognostic;promoter;Protocols documentation;pyrosequencing;Research;sample fixation;Sampling;Science;Specimen;Stains;standard of care;Standardization;statistics;Technology;temozolomide;Temperature;Testing;Thymine;Time;Tissue Banks;Tissue Embedding;Tissue Preservation;Tissue Sample;Tissues;tool;Transportation;treatment response;tumor;tumor heterogeneity;tumorigenesis;Validation;Variant;Warm Ischemia

PROJECT_TITLE: Influence of Pre-Analytical Factors in Globlastoma MGMT Promoter Methylation Biomarker Assay


NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Narrative Men with metastatic castration sensitive prostate cancer (mCSPC) are at high risk of disease progression and while the treatments used can delay progression, they can increase the risk of metabolic side effects (diabetes and heart disease). Data from our team has shown that intermittent fasting using a fasting mimicking diet (FMD) can improve metabolic health in people and delay cancer progression in mice, including in prostate cancer models. We propose a phase 2 multisite randomized trial of intermittent fasting with a FMD vs. standard of care in men with mCSPC designed to improve cancer control and reduce risk of diabetes, while gaining insight into how insulin and IGF1 signaling are associated with the benefit of FMD in delaying prostate cancer progression.

PI_NAMEs: DORFF, TANYA ;FREEDLAND, STEPHEN JAY (contact);LIN, PAO-HWA

PROGRAM_OFFICER_NAME: KIM, YOUNG S

PROJECT_TERMS: abiraterone;Affect;androgen deprivation therapy;Androgen Receptor;anti-cancer;anti-cancer research;Biology;Body Weight;Calories;Cancer Control;Cancer Patient;cancer subtypes;Cancer Survivor;cardiovascular risk factor;Cardiovascular system;Castrate sensitive prostate cancer;Castration;Cells;Cessation of life;chemotherapy;Clinical;Clinical Nutrition;Clinical Trials;Communities;comorbidity;Consumption;Data;design;Diabetes Mellitus;diabetes risk;Diet;dietary approach;Disease Progression;Eating;enzalutamide;European;experience;Fasting;Fatty acid glycerol esters;Glucose;Glycosylated hemoglobin A;Guidelines;Health;healthy volunteer;Heart Diseases;high risk;high risk men;Hormonal;Hormones;Human;IGF1 gene;improved;insight;Insulin;Insulin Resistance;Insulin-Like Growth-Factor-Binding Proteins;Intermittent fasting;Intervention;Leptin;Link;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Mediating;men;Metabolic;Metabolism;Metastatic Prostate Cancer;mimetics;Molecular;molecular subtypes;Morbidity - disease rate;mortality;mouse model;Mus;next generation;Outcome;Pathway interactions;Patients;Persons;Phase;phase II trial;Plants;Population;predictive signature;prevent;primary outcome;prostate cancer model;prostate cancer progression;prostate cancer risk;prostate cancer survivors;Randomized;randomized trial;Randomized, Controlled Trials;Resistance;response;Risk;Risk Reduction;Role;Second Primary Cancers;Serum;side effect;Signal Transduction;Site;skeletal;Societies;standard of care;Survivors;targeted agent;Testing;Testosterone;Thinness;Time;Toxic effect;transcriptomics;Treatment-related toxicity;tumor;tumor progression;Tumor Tissue;waist circumference

PROJECT_TITLE: Intermittent Fasting using a Fasting-Mimetic Diet to Improve Prostate Cancer Control and Metabolic Outcomes

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Prevention;Rare Diseases

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will provide a strong scientific justification to develop screening and to test preventive treatment strategies for subclinical hereditary transthyretin cardiac amyloidosis (hATTR-CA) in V122I TTR carriers. Key findings from this proposal will change how we think about this disease and will justify future research towards reducing HF morbidity and mortality by way of earlier hATTR- CA recognition and earlier treatment. Thus, the proposed research is relevant to part of the NHLBI's mission to promote the prevention and treatment of heart disease.

PI_NAMEs: GRODIN, JUSTIN LEE (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: Age;Amyloid;amyloid imaging;amyloidogenesis;Amyloidosis;biobank;Biological Markers;biomarker identification;Biophysics;Biopsy;Black Populations;Blood Tests;Cardiac;cardiac amyloidosis;cardiac magnetic resonance imaging;Cardiology;Carrier State;carrier status;carrier testing;cascade genetic testing;Cessation of life;circulating biomarkers;Clinic;clinical care;clinical research site;cohort;contrast enhanced;Data;Diagnosis;Diagnostic Specificity;diagnostic tool;diagnostic value;Disease;disease diagnosis;Disease Progression;Early Diagnosis;Early treatment;Enrollment;Epidemiology;Exercise;extracellular;Family member;Functional disorder;Gadolinium;Heart;Heart Diseases;Heart failure;Image;imaging detection;Imaging Techniques;improved;Individual;Infiltration;Inherited;innovation;Isoleucine;Kinetics;Left ventricular structure;Maps;Measures;Medical Genetics;Methods;Mission;Modeling;Monitor;Morbidity - disease rate;mortality;multidisciplinary;National Heart, Lung, and Blood Institute;novel;novel marker;novel therapeutics;Onset of illness;Patients;Phenotype;phenotypic biomarker;phenotypic data;Population;Positioning Attribute;Prealbumin;premature;prevent;Prevention;Preventive treatment;Process;Proteins;Public Health;Race;RBP4 gene;recruit;Research;Risk;Role;Sampling;screening;Serum;Severities;sex;specific biomarkers;Testing;Thick;Tissues;Treatment Failure;treatment strategy;United States;Universities;Valine;Variant;virtual;Work

PROJECT_TITLE: IDENTIFYING SUBCLINICAL TRANSTHYRETIN CARDIAC AMYLOIDOSIS IN ASYMPTOMATIC CARRIERS OF THE V122I TTR ALLELE

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Crohn's Disease;Digestive Diseases;Immunotherapy;Infectious Diseases;Inflammatory Bowel Disease;Neurodegenerative;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: AVIARA PHARMACEUTICALS, INC.

PHR: We are proposing the development of an orally available small molecule drug that targets inflammatory cell trafficking to the gut as a safe alternative to current treatments strategies in inflammatory bowel disease that either are associated with significant safety concerns, like the development of progressive multifocal leukoencephalopathy, or are associated with high numbers of primary and secondary non-responders to therapy.

PI_NAMEs: BIEDIGER, RONALD J;HOLLAND, GEORGE ;WOODSIDE, DARREN G (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: 6-Mercaptopurine;Address;Adopted;Adrenal Cortex Hormones;Affinity;Aminosalicylate;antagonist;Antibodies;Azathioprine;B-Lymphocytes;Benefits and Risks;Binding Proteins;Biodistribution;Biological;Biological Assay;Biological Availability;Biological Products;biomarker development;Blood;candidate selection;Canis familiaris;Caring;CD34 gene;Cell Adhesion Molecules;Cells;Chronic;Clinical;clinical candidate;clinical development;Clinical Trials;Colitis;Complex;cost;Crohn's disease;Cytochrome P450;design;Development;Disease;Dose;drug candidate;Drug Kinetics;Drug Targeting;dysbiosis;efficacy evaluation;Environmental Risk Factor;Etiology;Evaluation;Family;first-in-human;Funding;Future;Genetic;genotoxicity;Goals;Grant;Gut associated lymphoid tissue;gut inflammation;Hematopoietic Stem Cell Mobilization;Homing;Human;Immunologic Factors;immunomodulatory therapies;immunoregulation;improved;in vivo;Industry;Inflammatory;Inflammatory Bowel Diseases;inflammatory milieu;Inflammatory Response;Integrin alpha4;Integrin alpha4beta1;integrin alpha4beta7;Integrins;Interleukin-12;Intestinal Mucosa;JC Virus;Lead;lead candidate;Link;Lymphocyte;Lymphocytosis;Macaca fascicularis;Metabolic;Modeling;Monitor;Monoclonal Antibodies;Mus;Mutagenesis;natalizumab;Nature;nonhuman primate;novel strategies;Oral;Oral Administration;Outcome;patient population;patient subsets;Patients;Performance;Pharmaceutical Preparations;pharmacodynamic biomarker;Pharmacodynamics;pharmacologic;Pharmacology;Phase;phase 1 study;Phase I Clinical Trials;Play;Prognosis;programs;Progressive Multifocal Leukoencephalopathy;Property;Rattus;reactivation from latency;receptor;receptor binding;recruit;Research;response;Role;Route;Safety;safety study;scale up;screening;Selection Criteria;Small Business Technology Transfer Research;small molecule;stem cells;T-Lymphocyte;Testing;Therapeutic;TNF gene;Toxic effect;Toxicokinetics;Toxicology;trafficking;treatment response;treatment strategy;Ulcerative Colitis;Up-Regulation

PROJECT_TITLE: Selective targeting of high affinity alpha4 integrins as a safe treatment strategy for IBD


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Cell-cell interactions are crucial components of many biological processes including tumor-immune cells interactions. Although impressive progress has been made in developing single-cell analysis technology, existing techniques suffer from drawbacks in speed, resolution, biocompatibility, and automation; moreover, they cannot pair and separate cells reversibly. This project aims to develop and validate a harmonic acoustics-based microphysiological analysis platform that can perform high-throughput, high-resolution cell manipulation and perform quantitative phenotypic analyses of reversible cell-cell interactions at the single-cell level for a broad range of biomedical applications.

PI_NAMEs: LEE, LUKE P. (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Acoustics;Address;Advanced Development;Area;aspirate;Atomic Force Microscopy;Autoimmune Diseases;Automation;Bacterial Infections;behavioral study;Benchmarking;Biological;Biological Models;Biological Process;Biology;biomaterial compatibility;Biomedical Research;Cancer Biology;cancer cell;cancer drug resistance;Cardiovascular Diseases;cell behavior;Cell Communication;Cell Survival;cell type;Cells;Cellular biology;cellular pathology;Consumption;cost;Data;design;Development;Devices;Disease;drug discovery;energy efficiency;Exposure to;Frequencies;Generations;Homeostasis;Hour;Immune;Immunooncology;Impairment;improved;Industry Standard;intercellular communication;interest;invention;laser tweezer;Macrophage;Malignant Neoplasms;medical schools;Methods;Microfluidics;Modeling;Monitor;Nature;Neurodegenerative Disorders;next generation;novel therapeutic intervention;operation;optic tweezer;Optics;Pathology;Pattern;Performance;Phase;Phenotype;Physiological;Positioning Attribute;pressure;prevent;Procedures;Reporting;Research;Research Personnel;Resolution;Series;Signal Transduction;single cell analysis;Solid;Specific qualifier value;Spectrum Analysis;Speed;stem cells;Structure;T-Lymphocyte;Techniques;Technology;Testing;Therapeutic;Time;Tissues;tool;Transducers;transmission process;Tumor-infiltrating immune cells;user-friendly;Virus Diseases

PROJECT_TITLE: Harmonic Acoustics for Neighboring cell Dynamic studies(HANDs)

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]