NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: Los Angeles

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE We propose a global study of aging and Alzheimer’s disease to examine the aging of the brain’s tracts, or neural pathways, and relate their degeneration to important protective factors and risk factors. We develop new measures of brain aging, based on the white matter fibers in the brain; we ask how their aging trajectory is shifted by sex, genetic risk for AD, and amyloid levels in the brain. This global approach will give scientists a new source of power to “break the logjam” in discovering factors that affect the brain’s neural pathways as we age.

PI_NAMEs: THOMPSON, PAUL M (contact)

PROJECT_TERMS: 5 year old;abeta deposition;Address;Affect;Age;age acceleration;age related;age related decline;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;apolipoprotein E-4;biobank;Brain;Brain Diseases;Brain Injuries;brain magnetic resonance imaging;Brain Pathology;Brain scan;brain tract;brain volume;burden of illness;Cerebrum;Clinical;clinical predictors;Cognitive;cognitive performance;cohort;convolutional neural network;cost estimate;Data;data harmonization;Data Pooling;data repository;Data Set;Databases;Dedications;deep learning;demographics;Development;Diffusion Magnetic Resonance Imaging;Disease;Early identification;Ensure;Etiology;Fiber;Future;Genes;Genetic Risk;Genomics;Genotype;global health;Glucose;Haplotypes;high risk;Hippocampus;human old age (65+);imaging biomarker;Impaired cognition;in vivo;indexing;Individual;innovation;International;Learning;Life;life span;Machine Learning;magnetic resonance imaging biomarker;Mathematics;Measures;men;Methods;mild cognitive impairment;Molecular;MRI Scans;Neural Pathways;neural tract;neuroimaging;neuroimaging marker;normal aging;novel;novel strategies;Obesity;older adult;Pathologic;Pathway interactions;Pattern;Persons;PET positivity;Pharmaceutical Preparations;Pharmacologic Substance;polygenic risk score;Population;Positron-Emission Tomography;Power Sources;Prevalence;Property;protective factors;Reproducibility;Research;Risk;Risk Factors;risk variant;Running;Scheme;Scientist;sex;Societies;Source;Standardization;Stress;Structure;Symptoms;tau Proteins;Techniques;Testing;Tissues;tool;Treatment Efficacy;white matter;white matter damage;Woman;Work;β-amyloid burden

PROJECT_TITLE: FiberNET: Deep learning to evaluate brain tract integrity worldwide and in AD


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MADISON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative The production of misfolded, aggregation-prone, proteins in neurons, either through disease-associated mutation or as a consequence of reduced protein clearance capacity, is causally linked to the development of devastating neurodegenerative diseases, including frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). In this project we are using the fruit fly, Drosophila melanogaster, to discover pathways that diminish toxicity of an aggregation-prone protein termed UBQLN2 whose mutation is linked to familial forms of FTD and ALS. Discoveries made in flies will be leveraged to understand how UBQLN2 mutations instigate toxicity in stem cell-derived human neurons. In the future, this information may facilitate the development of drugs that attenuate ALS/FTD.

PI_NAMEs: TIBBETTS, RANDAL SCOT (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Address;Aging;Alleles;Alzheimer's disease related dementia;Amyotrophic Lateral Sclerosis;Apoptosis;Applications Grants;Attenuated;Autopsy;axon guidance;Axonal Transport;Binding;Binding Proteins;Biochemical;Cell Culture Techniques;Cell Line;cell type;Characteristics;Chromosome Mapping;Chromosomes;Clinical;Colon Carcinoma;Cytology;Defect;Dementia;Dependence;Development;Disease;Disease Pathway;Dissection;Dose;Drosophila genus;Drosophila melanogaster;drug development;Endosomes;Enhancers;Exhibits;Eye;Family;fly;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Future;Gene Expression Regulation;Gene Mutation;Genes;Genetic;genetic analysis;Genetic Screening;Genetic study;Goals;Heat Stress;Histopathology;Human;induced pluripotent stem cell;insight;interest;Lead;life span;Link;Mammalian Cell;Maps;Mediating;Missense Mutation;Modeling;Molecular Chaperones;Motor;Motor Neurons;mutant;Mutation;mutational status;Natural Immunity;Nerve Degeneration;Neurodegenerative Disorders;Neuromuscular Junction;neuron apoptosis;neuronal survival;Neurons;Neuropathogenesis;novel;Orphan;Parkinson Disease;Pathogenesis;Pathologic;Pathway interactions;Patients;Phenotype;Photoreceptors;Process;Production;Proline;Property;protein aggregation;protein degradation;protein folding;protein function;Proteins;Proteomics;proteostasis;proteotoxicity;receptor;sporadic amyotrophic lateral sclerosis;stem cells;Stress;System;Testing;Tissues;Toxic effect;trafficking;transcriptomics;ubiquilin;Ubiquitin;UBQLN1 gene;Up-Regulation

PROJECT_TITLE: Genetic analysis of UBQLN2-associated neurodegeneration in frontotemporal dementia


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Genetics;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative Senescent cells accumulate in aging and drive deficits accompanying age-associated diseases. This project investigates the role of a novel nuclear pathway, the G-quadruplex (G4) DNA pathway, in senescence of neurovascular unit (NVU) in the brain. The formation of G4 DNA is associated with chromatin remodeling, transcriptional changes, and DNA damage; we hypothesize that stabilization of G4s leads to senescence of the components of the NVU - endothelial cells, astrocytes, neurons, and pericytes.

PI_NAMEs: MARRELLI, SEAN P;TSVETKOV, ANDREY  (contact);URAYAMA, AKIHIKO

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Abbreviations;Acceleration;Affect;Age;age related;age-related disease;aged;Aging;aging brain;aging related;Alzheimer's Disease;Alzheimer's disease model;Amino Acids;Amyloid deposition;animal old age;Area;Artificial Intelligence;artificial intelligence algorithm;Astrocytes;Binding Proteins;blood-brain barrier permeabilization;Brain;Brain Diseases;Brain region;brain tissue;cancer cell;Cell Aging;Cell Physiology;Cell secretion;cell type;Cells;Cerebellum;Cerebrovascular Circulation;chemokine;Chromatin;chromatin remodeling;Circulation;Cognitive deficits;CXC chemokine receptor 3;CXCL10 gene;Cytoplasmic Granules;Data;dentate gyrus;Development;Diffusion;Disease;DNA;DNA biosynthesis;DNA Damage;DNA Sequence;effective therapy;Endothelial Cells;Exhibits;Extracellular Matrix;frontal lobe;frontotemporal lobar dementia amyotrophic lateral sclerosis;G-Quartets;Gene Expression;Gene Expression Alteration;Genes;Genetic Recombination;Genetic Transcription;Glucose;Goals;Guanine;Health;hippocampal pyramidal neuron;Hippocampus;Human;Impaired cognition;In Vitro;in vivo;Inflammation;Inflammatory;Interneurons;Location;Machine Learning;Metabolic;Metabolism;Mitotic;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neurons;neurovascular unit;normal aging;novel;Nuclear;Nutrient;old mice;oxidation;Parabiosis;Pathogenesis;Pathway interactions;Pericytes;Peripheral;Permeability;Phenotype;Play;postmitotic;prevent;Proteins;Regulation;Rejuvenation;Role;Running;Sampling;senescence;senescent cell;Shapes;Signal Transduction;small molecule;Stretching;Structure;Techniques;Tg2576;Tight Junctions;Transcriptional Regulation;Water

PROJECT_TITLE: G-quadruplex DNA in senescence of the neurovascular unit

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-A(50)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Structural Variants (SVs) could contribute to some of the missing heritability of Late-Onset Alzheimer’s Disease (LOAD). However, SVs have been not been accurately and thoroughly characterized in sequencing studies due to challenges in detection and validation of structural rearrangements. To address this gap in knowledge, we propose to comprehensively characterize SVs in LOAD using whole-genome sequencing data generated as part of the Alzheimer’s Disease Sequencing Project (ADSP), as well as additional long-read sequencing available through collaborators, which could identify novel locus disease relationships leading to putatively novel therapies.

PI_NAMEs: VARDARAJAN, BADRI N (contact);ZODY, MICHAEL C

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TERMS: Address;Affect;Age of Onset;Algorithms;Alzheimer's Disease;Award;Biological;case control;cohort;Complex;Consensus;Copy Number Polymorphism;Data;Data Set;Detection;Development;Diagnosis;diagnostic biomarker;Disease;DNA;DNA Insertion Elements;effective therapy;Elements;endophenotype;Episodic memory;Ethnic Population;Etiology;Family;follow-up;Frequencies;gene function;Genes;Genetic;genetic architecture;Genome;genome sequencing;genome wide association study;Genomics;Genotype;Goals;Heritability;human disease;improved;Individual;insertion/deletion mutation;insight;Joints;Knowledge;Late Onset Alzheimer Disease;Malignant Neoplasms;Maps;Methods;multi-ethnic;National Human Genome Research Institute;Neurodevelopmental Disorder;novel;novel therapeutics;Pattern;Phase;Phenotype;Population;Prevention strategy;Proteins;reference genome;Resources;Risk;Running;Sample Size;Sampling;Short Tandem Repeat;System;Technology;Testing;therapeutic biomarker;Trans-Omics for Precision Medicine;Validation;Variant;whole genome

PROJECT_TITLE: Characterizing complex structural variation in Alzheimer's disease

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Dementias, including Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD), are becoming a leading public health challenge in our progressively aging society. Neurofibrillary tangles made of tau protein represent a major pathological hallmark for AD, FTLD-tau and related tauopathies. RNA binding proteins (RBPs) are emerging as crucial players in regulating tau and other AD-associated genes. To understand molecular pathogenesis of dementia, we propose to use an integrated approach combining bioinformatics, molecular, biochemical approaches with animal models, patient samples and patient iPSC-derived neurons to define RBP networks that are critical for regulation of the human tau gene and disrupted in dementia. Our study will not only elucidate pathogenic mechanisms but also help in the future development of therapeutic strategies for dementia with tau pathology.

PI_NAMEs: VASSAR, ROBERT J (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Affect;Aging;Alternative Splicing;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease related dementia;Amyloid beta-Protein;Animal Model;Biochemical;Bioinformatics;Biological Assay;Brain;Brain region;candidate validation;Cell Line;cognitive function;cohort;Complex;Custom;Data;Data Set;Degenerative Disorder;Dementia;design;Disease;Elements;Exons;Frontotemporal Lobar Degenerations;Future;Gene Expression;Gene Expression Regulation;gene network;gene product;Gene Proteins;gene regulatory network;Genes;genetic regulatory protein;Genetic study;Goals;Human;human induced pluripotent stem cells;Impaired cognition;in vivo;indexing;Individual;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;innovation;insight;interdisciplinary approach;Introns;Knock-in;Knock-in Mouse;Messenger RNA;Methods;Modeling;Molecular;mouse model;mRNA Expression;mRNA Precursor;Multiomic Data;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;Neurons;neuropathology;neurotoxicity;novel diagnostics;novel therapeutic intervention;novel therapeutics;Pathogenesis;Pathogenicity;Pathologic;Pathology;patient derived induced pluripotent stem cells;Patients;Play;posttranscriptional;protein expression;Protein Isoforms;Proteomics;Public Health;Publishing;Regulation;resilience;risk variant;RNA;RNA analysis;RNA Splicing;RNA-Binding Proteins;Role;Sampling;Societies;Spliceosomes;tau aggregation;tau expression;tau Proteins;Tauopathies;Testing;therapeutic development;tool;transcriptome sequencing;Work

PROJECT_TITLE: The Role of RNA Binding Protein Networks in Tauopathy and Related Dementia

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: PATHOLOGY

PHR: Alzheimer’s disease (AD) is the most common cause of dementia and a leading cause of death in the United States, yet there are currently no effective treatments to slow or halt disease progression. This proposal seeks to understand how chronic stress, an AD risk factor, induces molecular/cellular changes that precipitate or exacerbate disease progression. These studies will facilitate the development of treatments to prevent or slow the progression of this devastating disease.

PI_NAMEs: WAITES, CLARISSA LEIGH (contact)

PROJECT_TERMS: Acceleration;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;American;Amyloid beta-Protein;Anatomy;Animal Model;Animals;Astrocytes;Atrophic;Biochemistry;Biological;Biological Markers;Blood;Brain;brain dysfunction;Brain Pathology;Brain region;brain tissue;Cause of Death;cell type;Cells;Chronic;Chronic stress;Clinical Research;Complex;conditional knockout;Defect;Degradation Pathway;Dementia;density;Diagnosis;Disease;Disease Progression;Down-Regulation;Early Diagnosis;Early treatment;effective therapy;entorhinal cortex;Environmental Risk Factor;epidemiology study;Exhibits;exosome;experimental study;Exposure to;extracellular vesicles;Functional disorder;Gene Expression Profiling;genetic risk factor;Genetic Transcription;Glucocorticoid Receptor;Glucocorticoids;hippocampal atrophy;Hippocampus;Hormones;human old age (65+);Image;Immune;Immunofluorescence Microscopy;Impairment;in vivo;Injections;innovation;intercellular communication;Knockout Mice;Label;Learning;Link;MAPT gene;Mediating;Mediator;Memory impairment;Microglia;MicroRNAs;miRNA expression profiling;Molecular;Monitor;mouse model;Mus;nanoparticle;Neocortex;Neuroglia;Neurons;neurotoxicity;new therapeutic target;Pathogenesis;Pathology;Plasma;potential biomarker;prevent;Process;Property;Proteins;Proteomics;Psychological Stress;Publishing;Regulation;reuptake;Risk;Risk Factors;Role;sex;Sex Differences;Stress;tau aggregation;tau expression;tau mutation;tau Proteins;Tauopathies;Testing;therapeutic biomarker;therapy development;Tissues;transcriptome;United States;uptake;Vertebral column;Vesicle;Wild Type Mouse;Work

PROJECT_TITLE: Uncovering stress-induced mechanisms of Tau pathology in Alzheimer's disease


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: TROY

ORG_DEPT: BIOLOGY

ORG_NAME: RENSSELAER POLYTECHNIC INSTITUTE

PHR: Alzheimer’s disease (AD) is one of the most serious challenges to public health in US. Tau protein aggregates to form neurofibrillary tangle (NFT), a pathological hallmark of AD. NFT spreads transcellularly via the interaction between tau and cell surface glycans. We will study the structural details of tau-glycan interaction for structure-based drug discovery. The detailed data on the interaction between tau and glycan will provide tremendous insight into molecular mechanism of tau pathology and AD pathogenesis, and point to new directions in AD drug discovery.

PI_NAMEs: LINHARDT, ROBERT J;LIU, JIAN ;WANG, CHUNYU  (contact);WANG, LIANCHUN

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease therapy;Animal Model;Binding;Biosensor;Brain;Cell Culture Techniques;Cell Line;cell motility;Cell surface;cell type;Cells;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Core Protein;Data;Dementia;design;Disaccharides;Disease;Dissociation;Drug Design;drug development;drug discovery;Enzymes;Fluorescence Resonance Energy Transfer;Future;Glucosamine;Glucuronic Acids;Goals;Heparan Sulfate Proteoglycan;Heparitin Sulfate;Hippocampus;hTau Mice;Human;Iduronic Acid;Impaired cognition;inhibitor;Injections;insight;Link;Maps;MAPT gene;Mass Spectrum Analysis;Mediating;Methods;Microtubule Stabilization;Microtubules;mimetics;Modification;Molecular;molecular dynamics;mouse genetics;mouse model;Movement;Mutagenesis;neural network;Neurofibrillary Tangles;Neurons;novel;Oligosaccharides;overexpression;Pathogenesis;Pathologic;Pathology;Pattern;Pharmaceutical Preparations;Physiology;Play;Polysaccharides;prion-like;protein aggregation;Proteins;Public Health;Relaxation;restraint;Role;role model;Signal Transduction;Small Interfering RNA;Staging;structural biology;Structure;Sulfate;sulfotransferase;Surface;tau aggregation;tau interaction;tau Proteins;Tauopathies;Testing;tool;Translating;uptake;Uronic Acids;Work

PROJECT_TITLE: Heparan Sulfate 3-O-Sulfation in Transcellular Propagation of Tauopathy in Alzheimer's Disease

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: AUGUSTA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: Alzheimer's disease (AD) is the major causeof devastating late-life dementia and currently there are no effective treatments to stop its progression. Using an integrative approach, this study aims to advance our understanding of the complex interaction between AD risk factors and to provide invaluable preclinical information on new treatment strategies. If successful, this study would advance our fundamental knowledge of the complication of AD pathophysiology and lead to a new direction for AD treatment.

PI_NAMEs: WANG, QIN  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Abeta clearance;Affect;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease risk;Amyloid beta-Protein;amyloid precursor protein processing;Animal Model;ARRB2;atypical protein kinase C;Autopsy;autosome;beta amyloid pathology;beta-arrestin;Brain;brain tissue;Cognitive deficits;comparison control;Complex;Complication;Consensus;Data;Dementia;Disease;Early Endosome;Early Onset Alzheimer Disease;effective therapy;Endosomes;Etiology;Event;Exhibits;FDA approved;Functional disorder;gain of function;Gene Dosage;Genes;genetic approach;genetic risk factor;genetic variant;Genetic Variation;genome wide association study;Goals;Half-Life;Human;Impairment;inhibitor;Knock-in;Knowledge;late life;Late Onset Alzheimer Disease;loss of function;Lysosomes;Mediating;Membrane Proteins;Metabolism;Missense Mutation;Modeling;Morphology;Neurons;Nonsense Mutation;novel;novel therapeutic intervention;Pathogenesis;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;Population;pre-clinical;Preclinical Testing;Prefrontal Cortex;Preventive;Process;Property;protective factors;Protein Isoforms;Proteins;receptor;Regulation;Regulatory Pathway;Research;retrograde transport;Rheumatoid Arthritis;Risk Factors;Role;Sampling;Signal Transduction;Signaling Molecule;Site;Sorting;Synapses;Testing;Therapeutic;therapeutic target;Tissues;trafficking;trans-Golgi Network

PROJECT_TITLE: Regulation of SORLA by beta-arrestin2

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND-M]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Hematology

ORG_CITY: GREENVILLE

ORG_DEPT: PHYSICS

ORG_NAME: EAST CAROLINA UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Blood clots form at the site of injuries, preventing the loss of blood during wound healing. Fibrin fibers hold blood clots together until they are broken down by enzymes after the wound healing process. In this project, we seek to study the polymerization of fibrin fibers to determine the mechanisms of fiber growth and branching and to understand how these processes affect the final clot structure and its enzymatic breakdown.

PI_NAMEs: HUDSON, NATHAN  (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TITLE: How do early stages of fibrin fiber assembly affect clot structure and lysis

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Microbiome;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Alzheimer's disease is a devastating neurodegenerative disease that affects 5.5 million Americans, and the greatest risk factor is age. The intestine contains trillions of bacteria that influence many aspects of health and disease, and we have found that by affecting the bacteria in the gut during aging, we can reduce disease in an animal model of Alzheimer’s disease. We will investigate the mechanisms by which this occurs in hopes of identifying new therapeutic targets for treatment of Alzheimer’s disease.

PI_NAMEs: WEINER, HOWARD L (contact)

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: Abeta clearance;Affect;Age;age acceleration;age related changes;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;American;Amyloid beta-Protein;amyloid precursor protein processing;Animal Model;Antibiotic Therapy;Antibiotics;Apolipoprotein E;Bacteria;Bacteroides;Bacteroides fragilis;Bacteroidetes;Brain;Cell Wall;Data;Deposition;Disease;disease phenotype;Down-Regulation;Enzymes;FOXP3 gene;Functional disorder;Gene Expression;Golgi Apparatus;Granulocyte-Macrophage Colony-Stimulating Factor;gut bacteria;gut microbes;gut microbiota;Health;Human;human microbiota;Immune signaling;Immune system;Immunity;Impaired cognition;Individual;Inflammatory;Innate Immune Response;Insulinase;interest;Intervention;Intestines;Laboratories;Link;Macrophage;Mediator;metabolomics;metagenomic sequencing;Metagenomics;Metronidazole;Microbe;microbial;microbiome;microbiota;microbiota composition;Microglia;migration;monocyte;Mus;Natural Immunity;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neurodegenerative phenotype;neurotoxicity;new therapeutic target;novel;Pathogenesis;Pathology;Pathway interactions;Peripheral;Phagocytosis;Phenotype;Phosphorylation;Play;recruit;Regulation;Regulatory T-Lymphocyte;Reporting;Ribosomal RNA;Risk Factors;Role;Senile Plaques;Serum;Shotguns;Signal Pathway;T-Lymphocyte;tau Proteins;tau-1;Testing;trafficking;TREM2 gene

PROJECT_TITLE: The role of microbiota in aging and Alzheimer's disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: PSYCHIATRY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Premature onset of age-related diseases and neurocognitive decline are a major public health concern as these conditions substantially decrease the number of years an individual is well and able to contribute to society; they simultaneously lead to more years of high-cost healthcare. This longitudinal study of at-risk older adults will identify easily-acquired peripheral biomarkers and genetic variants that serve as prognostic indicators of later brain health (as indicated by brain neurochemistry and neurocognitive assessment). This will allow for new targeted interventions to slow the pace of cellular aging, improve health, reduce the broader burden of disease, and increase human lifespan.

PI_NAMEs: WOLF, ERIKA J (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: accelerated epigenetic aging;Acceleration;Age;age acceleration;Age of Onset;age-related disease;Algorithms;Alzheimer's Disease;Amyloid beta-Protein;Apolipoproteins;Biological;Biological Markers;Biological Specimen Banks;biomarker validation;Brain;brain health;Brain Injuries;burden of illness;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;cell age;Cell Aging;Chemicals;Chronology;clinical predictors;cognitive function;cohort;cytokine;Data;Dementia;dementia risk;Deposition;disorder risk;DNA Library;DNA Methylation;Early identification;early onset;Economics;Epigenetic age;epigenome;excitotoxicity;follow-up;frailty;Genetic;Genetic Risk;genetic variant;genome-wide;Genomics;Genotype;Health;Health Care Costs;healthspan;Human;human old age (65+);human subject;Impaired cognition;improved;indexing;Individual;Inflammation;Inflammatory;inflammatory marker;Intervention;Lead;life span;Longitudinal cohort;Longitudinal Studies;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measures;Mediating;Mediator;Metabolic;Metabolic Marker;Metabolic syndrome;methylation pattern;middle age;mild cognitive impairment;molecular marker;Morbidity - disease rate;mortality;myoinositol;N-acetylaspartate;Nerve Degeneration;neural;neurochemistry;Neurocognitive;Neurocognitive Deficit;neuroinflammation;Neurologic;Neurons;neuropathology;Neuropsychology;novel;Obesity;older adult;Outcome;Oxidative Stress;Participant;Pathology;Performance;Peripheral;Phenotype;Plasma;Ploidies;predictive marker;Predictive Value;premature;Process;prognostic indicator;Prognostic Marker;psychiatric symptom;psychologic;Public Health;rate of aging;recruit;Research Personnel;Risk;Risk Factors;Sampling;Science;Signs and Symptoms;small molecule;Societies;Syndrome;tau Proteins;Techniques;Technology;Time;Trauma;trauma exposure;trauma symptom;traumatic stress;Veterans;Visualization;Work

PROJECT_TITLE: Longitudinal Neurometabolic Outcomes of Traumatic Stress-Related Accelerated Cellular Aging

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative This proposal aims to improve our current understanding of selective network vulnerability and network resilience in aging and Alzheimer’s disease using longitudinal network analyses. To achieve this goal, we will develop a set of network-based computational tools to (1) identify the harmonic-selective vulnerability that has critical role in cognitive decline, and (2) characterize network resilience that moderate the trajectory of cognitive decline. Based on the discovery of network vulnerability and resilience, we will further explore the diagnostic value of new harmonic-genetics biomarkers and resilience in predicting cognitive decline on an individual basis.

PI_NAMEs: WU, GUORONG  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Affect;Alzheimer's Disease;Alzheimer's disease diagnostic;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Area;Atrophic;base;Biological Markers;biophysical analysis;Brain;Brain Mapping;Brain region;cell type;Clinic;Cognition;Cognitive;Communities;Computer software;computerized tools;connectome;Cross-Sectional Studies;Data;Development;diagnostic value;Discipline;Education;Event;Evolution;Exhibits;Factor Analysis;flexibility;fluorodeoxyglucose positron emission tomography;Genetic;genetic approach;Genetic Markers;genome wide association study;Goals;Grain;Impaired cognition;improved;Individual;Lead;Link;Longitudinal Studies;Measurement;Methodology;Methods;Modeling;modifiable risk;Molecular;Nerve Degeneration;network dysfunction;Network-based;Neurobiology;neurocognitive disorder;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroimaging;neuron loss;Neurons;neuropathology;Neurosciences;normal aging;novel;Occupations;Pathologic;Pathology;Pathway Analysis;Pathway interactions;Pattern;Phenotype;Physics;Positron-Emission Tomography;precision medicine;preservation;Process;programs;Research;resilience;resilience in aging;Risk;Risk Factors;Role;self organization;Senile Plaques;Single Nucleotide Polymorphism;Source Code;spectral energy;statistics;Structure;System;tau Proteins;Testing;Thick;tool;Vertebral column

PROJECT_TITLE: Understanding Selectivity Mechanisms of Network Vulnerability and Resilience in Alzheimer's Disease by Establishing a Neurobiological Basis through Network Neuroscience

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Sarcopenia

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: The proposed research is to test the hypothesis that APP Swedish mutation causes NMJ decline in aged mice by impairing agrin signaling and causing cellular senescence in the muscle. Results will uncover new pathological mechanisms of AD-associated muscle weakness.

PI_NAMEs: XIONG, WEN-CHENG  (contact);ZIGMOND, RICHARD E

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Address;Affect;Age Years;Aging;aging related;Agrin;Alzheimer's Disease;Alzheimer's disease patient;Amyloid beta-Protein Precursor;Binding;Birth;Brain;Cell Aging;cell growth;Cognitive deficits;Dementia;Development;Disease;experimental study;Homologous Gene;human old age (65+);Impairment;improved;Induced Mutation;innovation;Interleukin-6;Knowledge;LDL-Receptor Related Protein 1;Lipoprotein Receptor;Maintenance;Memory Loss;mild cognitive impairment;Motor;Mus;Muscle;muscle aging;Muscle Cells;Muscle Contraction;Muscle Fibers;muscle form;muscle strength;Muscle Weakness;Muscular Atrophy;MUSK gene;mutant;Mutation;Nerve;Neuromuscular Diseases;Neuromuscular Junction;neuromuscular transmission;neurotransmission;old mice;Pathologic;pathological aging;Peripheral;Personality;Phenotype;Population;postsynaptic;presynaptic;prevent;Process;Proteins;Proteoglycan;reduced muscle strength;Research;Risk;risk variant;senescence;Signal Transduction;Skeletal Muscle;Swedish mutation;Synapses;synaptic function;Testing;Therapeutic Intervention;therapeutically effective;Time;Tissues;TNF gene;transmission process

PROJECT_TITLE: Swedish APP mutation and NMJ decline in Alzheimer's disease

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR-M]


PHR: This proposal will focus on a potentially novel regulatory mechanism for astrocytic Aβ uptake by LRP4 (LDLR-related protein 4). The proposed studies will shed new light on AD pathogenesis. Such knowledge is prerequisite to the development of new therapeutic strategies for AD.

PROJECT_TERMS: Abeta clearance;Ablation;Affect;Agrin;agrin receptor;Alleles;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid beta-Protein;Amyloid deposition;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Astrocytes;Autopsy;Brain;brain tissue;Cell Physiology;cell type;cognitive change;cognitive function;Dementia;Development;Down-Regulation;Episodic memory;Extracellular Domain;Goals;Hippocampus;human old age (65+);human very old age (85+);Impaired cognition;Impairment;Integral Membrane Protein;Knowledge;LDL-Receptor Related Protein 1;Link;long term memory;Mediating;Membrane;Motor Neurons;mouse model;Mus;mutant;Mutation;Neurofibrillary Tangles;Neuroglia;Neuromuscular Junction;novel;novel therapeutic intervention;Pathogenesis;Pathway interactions;Personality;Persons;Pilot Projects;Population;Prefrontal Cortex;prevent;prorenin receptor;Protein Tyrosine Kinase;Proteins;Publishing;Receptor Up-Regulation;receptor upregulation;recruit;release factor;Research;Role;selective expression;Senile Plaques;Surface;Testing;uptake;vacuolar H+-ATPase

PROJECT_TITLE: LRP4 deficiency in Alzheimer's disease development


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Alzheimer's disease (AD) is the most common cause of dementia that has no effective cures and inexorably worsens over time. The proposed research will use cutting-edge neuroscience techniques to examine an important newly identified hippocampal sub-circuit mechanism and its relation to AD-related memory impairments in AD-like mouse models. Our findings may be used to better treat the disease, delay its onset, and prevent it from developing.

PI_NAMEs: XU, XIANGMIN  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Adult;Age;Age-associated memory impairment;aged;Alzheimer associated neurodegeneration;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Amyloid beta-Protein;Amyloid deposition;Animals;Autopsy;Axon;Back;Behavior;behavior test;Behavioral;behavioral impairment;Brain;Cells;Data;Defect;Dementia;Disease;Disease Progression;Elderly;Environment;Etiology;excitatory neuron;Experimental Designs;experimental study;Genetic;Head;Health;Hippocampus;Human;human old age (65+);Image;Impairment;improved;in vivo;Individual;information processing;Knock-in;Knock-in Mouse;Lead;Learning;Link;Literature;Location;Maps;Measures;Memory;memory encoding;Memory impairment;Microscope;microscopic imaging;Modeling;Morphologic artifacts;mouse model;Mus;Mutation;Nerve Degeneration;neural;neural circuit;neural correlate;neuroimaging;neuromechanism;Neurons;neuropathology;Neurosciences;new therapeutic target;optogenetics;Output;overexpression;Pathogenicity;Pathologic;Pathway interactions;Pattern;Performance;Physiological;Population;prevent;Publishing;rabies viral tracing;Research;Resolution;Route;Running;Simplexvirus;spatial memory;Specific qualifier value;Techniques;Testing;Time;Tracer;Transgenic Mice;treatment strategy;United States;Wild Type Mouse

PROJECT_TITLE: Neural circuit mechanisms underlying AD-related memory impairments


ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PROJECT NARRATIVE With the increase of life expectancy in today’s world, more and more people are diagnosed to have Alzheimer’s disease (AD) or other aging-related cognitive dysfunction. Alzheimer’s disease (AD is characterized by the presence of extracellular neuritic plaques and intraneuronal neurofibrillary tangles. In addition to amyloid plaques and neurofibrillary tangles, the presence of dystrophic neurites (DNs), referring to aberrant neuritic sprouting as well as swollen dendrites and/or axons, is known as one pathological feature in surrounding amyloid plaques on AD postmortem brains, and has been shown to correlate with cognitive dysfunctions in AD. With the increasing number of failures in clinical trials that target the formation of amyloid deposition, AD treatment is recognized to be extremely challenging. This study aims to explore the approach for preventing or reducing DNs.

PI_NAMEs: YAN, RIQIANG  (contact)

PROJECT_TERMS: 3-Dimensional;abeta accumulation;Address;Aging;aging brain;aging related;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Amyloid deposition;amyloid formation;amyloid pathology;Animal Model;Antibodies;Area;Astrocytes;Autophagocytosis;Autophagosome;Autopsy;Axon;Biochemical Genetics;bioinformatics tool;Brain;Clinical Trials;Coculture Techniques;cognitive function;conditional knockout;Cultured Cells;Data;Dendrites;Diagnosis;Diffuse;Electron Microscopy;Endoplasmic Reticulum;Endosomes;experimental study;extracellular;Failure;Functional disorder;Funding;Genes;genetic approach;Golgi Apparatus;Growth;Immune;immunoreactivity;Impaired cognition;Impairment;improved;Inclusion Bodies;intraneuronal beta amyloid;Knock-in;Knowledge;Label;Life Expectancy;Light;Mediating;Membrane;Microglia;Modeling;Molecular Target;Morphology;mouse genetics;Mus;Names;Neurites;Neurodegenerative Disorders;neurodegenerative phenotype;Neurofibrillary Tangles;Neurons;non-demented;Pathogenesis;Pathologic;Persons;Population;prevent;Process;Proteins;receptor expression;reconstruction;Role;Senile Plaques;Shapes;single-cell RNA sequencing;Structure;Swelling;Synaptic plasticity;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;trafficking;Tubular formation;Ubiquitin;Vesicle

PROJECT_TITLE: Roles of reticulon proteins in neurodegenerative disorders


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Conditions Affecting the Embryonic and Fetal Periods;Electronic Nicotine Delivery Systems;Fetal Alcohol Spectrum Disorders (FASD);Genetics;Intellectual and Developmental Disabilities (IDD);Microbiome;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Substance Misuse;Tobacco

ORG_CITY: WEST CHESTER

ORG_DEPT: PSYCHOLOGY

ORG_NAME: WEST CHESTER UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE:  Alcohol and electronic cigarettes are often used together, including by pregnant individuals; however, it's unclear whether using both substances during pregnancy has a larger impact on a developing fetus compared to using only one of the drugs alone. To investigate this, we will expose neonatal mice to alcohol, nicotine via e- cigarettes, or the combination during a critical brain developmental period and measure physiological levels of each drug and their metabolites, serum triglyceride levels, microbiota presence, motor- and anxiety-related behaviors, and related gene expression levels. This project will be conducted by undergraduate research students in the Psychology, Biology, and Chemistry departments at West Chester University.

PI_NAMEs: BREIT, KRISTEN RIAN (contact);KWIATKOWSKI, THOMAS ;SWEET, ERIC S

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acute;Air;Alcohol consumption;Alcohol dehydrogenase;alcohol effect;alcohol exposure;Alcohols;Anxiety;anxiety-related behavior;Behavior;Behavioral;Biochemical;Biological Assay;Biology;Blood;Blood alcohol level measurement;Blood drug level result;Brain;Brain region;Chemistry;Clinical;Consumption;critical period;Critical Thinking;CYP2E1 gene;Data;Development;Devices;Diagnosis;Discipline;Doctor of Philosophy;Dose;Drug Exposure;drug metabolism;Electronic cigarette;electronic cigarette use;Enzymes;Ethanol;examination questions;experience;Exposure to;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fetal Development;Forelimb;Future;Gene Expression;Gene Expression Alteration;Genes;Goals;graduate student;Growth;gut microbiome;gut microbiota;Hand;higher education;Human;Hyperactivity;Individual;Inhalation;late life;Life;Literature;Liver;Measures;Medical;medical schools;Messenger RNA;metagenomic sequencing;Methods;microbiota;microbiota composition;Modeling;Mothers;Motor;motor impairment;mouse model;multidisciplinary;Neonatal;neonatal exposure;neonatal mice;neonate;Neurologic;Nicotine;nicotine exposure;nicotine use;novel;offspring;Oral;Pattern;Persons;Pharmaceutical Preparations;Pharmacology;Physiological;Plasma;Population;Population Analysis;postnatal;pre-clinical;Pregnancy;pregnant;prenatal;prenatal nicotine exposure;Prevalence;Process;programs;Psychology;Publications;Research;Research Assistant;Reverse Transcription;Route;sample collection;Serum;sex;Shotguns;skills;Stress;Students;substance use;Teratology;Third Pregnancy Trimester;Time;Tissue Banks;Tissue Sample;Tissues;Triglycerides;undergraduate research;undergraduate student;Universities;vaping;vapor;Western Blotting;Writing

PROJECT_TITLE: Effects of Developmental Alcohol and Nicotine E-Cigarette Co-Exposure on Physiological Measures and Behavioral Development

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric;Rare Diseases

ORG_CITY: LOWELL

ORG_NAME: UNIVERSITY OF MASSACHUSETTS LOWELL

PHR: PROJECT NARRATIVE First arch pharyngeal endoderm and ectoderm are critical to patterning and proliferation of the jaw and also differentiate into components of the ear. Fgf8 is a key signaling factor expressed in these tissues, and this project aims to uncover molecular and cellular processes contributing to Fgf8 regulation of pharyngeal devleopment. Fgf8 is implicated in 22q11 deletion syndrome and more broadly in facial asymmetry, therefore, work in this proposal may improve the diagnosis and treatment of these craniofacial disorders.

PI_NAMEs: FISH, JENNIFER LESLIE (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: 22q11;Affect;Birth;Branchial arch structure;Buffers;Cell Physiology;Cells;Cellular biology;CHARGE syndrome;Congenital Abnormality;craniofacial;Craniofacial Abnormalities;craniofacial disorder;Data;Defect;Development;Diagnosis;DiGeorge Syndrome;Disease;Disease Outcome;dosage;Ear;Ectoderm;Eligibility Determination;Embryo;Endoderm;Environment;Epithelial Cells;Epithelium;Exhibits;Face;Facial asymmetry;First Pharyngeal Arch;first pharyngeal pouch;Genetic Models;Genotype;Head and neck structure;Heart;heart defect;Human;improved;in vitro Model;in vivo;insight;Institution;Intercellular Junctions;Jaw;Left;malformation;Mediating;Mesenchymal;Mesenchyme;Mesoderm;Messenger RNA;migration;Molecular;Molecular and Cellular Biology;Morphogenesis;Morphology;mutant;Neural Crest;Neural Crest Cell;Neural tube;Nuclear;Outcome;Pattern;Penetrance;pharyngeal patterning;Pharyngeal pouch;Pharyngeal structure;Population;Primitive foregut structure;progenitor;Proliferating;Protein Isoforms;Regulation;Research;RNA Splicing;Role;Severities;Shapes;Side;Signal Transduction;Skeleton;Structure;Surface Ectoderm;Syndrome;Testing;Tissues;trend;undergraduate student;Variant;Work

PROJECT_TITLE: Molecular and cellular mechanisms underlying Fgf8-dosage mediated defects in jaw size and symmetry

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-C (81)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Genetics;Human Genome

ORG_CITY: BOWLING GREEN

ORG_NAME: BOWLING GREEN STATE UNIVERSITY

PHR: PROJECT NARRATIVE The domestic dog provides an important biomedical model of human genetics and disease but until now has been excluded from research of retrovirus-host biology. We propose to functionally characterize a recently discovered group of endogenous retroviruses that we have shown has recent and putatively ongoing infectious activity in canines. The results from this study will span a significant knowledge gap in our understanding of retrovirus-host dynamics in this underexplored model and improve our understanding of the mechanisms and outcomes of expression of this zoonotic-relevant and highly intact retrovirus lineage in the dog.

PI_NAMEs: HALO, JULIA VERA (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Animal Model;Animals;Antibody Response;Area;arms race;Basic Science;Binding Sites;Biological;Biological Assay;Biology;Breeding;canine model;Canis familiaris;Cell Line;Cell Proliferation;Clinical Research;Code;Companions;comparative;Comparative Study;Competence;Complement;Conserved Sequence;cross-species transmission;Data;Data Analyses;Disease;DNA;dog genome;Endogenous Retroviruses;Enhancers;enzyme activity;Exclusion;experience;Fellowship;functional outcomes;Gene Activation;Gene Expression;gene function;Generations;Genes;Genetic;Genetic Polymorphism;Genetic Transcription;Genome;genome resource;Genomic DNA;genomic variation;Genomics;Germ Lines;Goals;Health;Human;human disease;Human Genetics;Human Genome;human model;Human Resources;Immune response;immunoregulation;improved;Infection;Institution;Invaded;Investigation;Knowledge;LacZ Genes;Link;Luciferases;Lymphoma;Malignant Neoplasms;Mediating;Mediator;Methods;Methylation;Modeling;Modernization;mouse genome;novel;offspring;Oncogenic;Open Reading Frames;Outcome;particle;Pathogenicity;permissiveness;Productivity;progenitor;programs;promoter;Property;Proteins;Proviruses;Qualifying;Rapid screening;receptor;Recombinants;Reporter;Reporting;Research;Research Personnel;Resources;Retroviridae;Reverse engineering;RNA;RNA Splicing;Role;sample fixation;Sampling;Site;Source;Structure;student training;Students;syncytin;System;Testing;Time;Training;transcription factor;Transcriptional Activation;transmission process;tumor;tumorigenesis;undergraduate research;Variant;Viral;Viral Genes;Viral Genome;Virus;Work;Zoonoses

PROJECT_TITLE: Impact of endogenous retroviruses in the domestic dog


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Infectious Diseases;Prevention

ORG_CITY: CHATTANOOGA

ORG_NAME: UNIVERSITY OF TENNESSEE CHATTANOOGA

ORG_STATE: TN

PHR: Project Narrative The overall goal of this study is to investigate the impact of exogenous polyunsaturated fatty acids (PUFAs) on bacterial membrane lipid homeostasis using in vitro and in silico approaches. We will explore the value of exogenous PUFAs to Vibrio cholerae by characterizing the various structural modifications to membrane phospholipids and determining how incorporation of these molecules influences bacterial permeability and antimicrobial resistance. Ultimately, PUFAs may influence bacteria in a manner that affects their susceptibility to antibiotic treatment, thus introducing another avenue for prevention and therapeutic intervention of diseases caused by antibiotic sensitive and resistant pathogens.

PI_NAMEs: GILES, DAVID  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Affect;Antibiotic susceptibility;Antibiotic Therapy;Antibiotics;antimicrobial;Antimicrobial Resistance;Bacteria;Biological Assay;Biological Process;Carbon;Cell membrane;Cell Membrane Permeability;Cessation of life;Cholera;Clinical;combat;Data;design;Disease;disease diagnosis;disorder prevention;Dyes;Enteral;Environment;Exhibits;Fatty Acids;Foundations;Gene Expression Regulation;Goals;Gram-Negative Bacteria;Homeostasis;Human;Impact evaluation;improved;in silico;In Vitro;in vitro testing;Infection;innovation;insight;intercalation;interest;Intervention;Investigation;Iron;Knowledge;Lactose;Lipids;long chain fatty acid;Mediating;Medical;Membrane;Membrane Lipids;Metabolic;Methodology;Microbe;Minerals;Mission;models and simulation;Modification;molecular dynamics;National Institute of General Medical Sciences;Nature;Nonesterified Fatty Acids;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Permeability;Phenotype;Phospholipids;Polyunsaturated Fatty Acids;Predisposition;Prevention;preventive intervention;Process;Property;protein function;Public Health;Publications;Publishing;Recycling;Research;Resistance;Resources;response;Role;Signaling Molecule;Source;sugar;Therapeutic;Therapeutic Intervention;Thin Layer Chromatography;translational impact;transmission process;uptake;Vibrio;Vibrio cholerae;Virulence;Work

PROJECT_TITLE: In vitro and in silico investigations of changes in bacterial cell membrane dynamics due to polyunsaturated fatty acid (PUFA) modifications

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Dementia;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_CITY: LAS VEGAS

ORG_NAME: UNIVERSITY OF NEVADA LAS VEGAS

ORG_STATE: NV

PHR: NARRATIVE Alzheimer's disease (AD) is the leading cause of dementia that currently does not have effective treatment. There is a growing necessity for early identification of those at high risk of dementia decades before the onset of symptoms. With artificial intelligence and genetic data-transformed artificial image objects, we propose a new approach to create models to improve AD prediction and biomarker identification, which has the potential to facilitate earlier diagnosis, prevention, or intervention for AD and even other complex diseases.

PI_NAMEs: CHEN, JINGCHUN  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Acceleration;Affect;African ancestry;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;Alzheimer’s disease biomarker;Area Under Curve;Artificial Intelligence;artificial intelligence algorithm;Astrocytes;Big Data;Biological Markers;biomarker discovery;biomarker identification;biomarker validation;Biometry;career;career development;cell type;Classification;Clinic;Clinical;clinical practice;Collaborations;comorbidity;Complex;convolutional neural network;Coupled;Data;Data Analyses;Data Set;data-driven model;Dementia;dementia risk;design;Diagnosis;differential expression;Dimensions;Disease;disease classification;disease heterogeneity;disease model;disorder risk;drug development;drug discovery;early detection biomarkers;Early Diagnosis;Early identification;effective therapy;Effectiveness;European;Face;Faculty;field study;Future;Genes;Genetic;Genetic Heterogeneity;Genetic Models;Genetic Risk;genetic variant;genome wide association study;Genotype;Goals;Grant;health inequalities;high risk;high risk population;Image;improved;Individual;innovation;insight;interest;Intervention;Logistic Regressions;Machine Learning;machine learning algorithm;Malignant Breast Neoplasm;Maps;Medical;member;Methods;Microglia;Modeling;Multiomic Data;neural network algorithm;Neural Network Simulation;novel strategies;Pathway interactions;Pattern;Performance;Persons;polygenic risk score;Population;predictive modeling;Preservation Technique;Prevention;random forest;Regression Analysis;Research;Research Activity;Research Personnel;Resources;Risk Assessment;Schizophrenia;Single Nucleotide Polymorphism;single-cell RNA sequencing;specific biomarkers;statistics;Students;success;support vector machine;Symptoms;Techniques;Testing;therapeutic target;trait;transcriptome sequencing;Translating;United States;Validation;Variant

PROJECT_TITLE: Convolutional Neural Network for Disease Prediction, Biomarker Discovery, and Validation in Alzheimer's Disease

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Social Determinants of Health;Suicide

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative  Gender minority adolescents (GMAs; adolescents whose gender identity is different than their sex assigned at birth) have extremely high risk for suicidal behavior, but little is known about how psychosocial experiences contribute to GMA risk for suicidal behavior. The proposed longitudinal study will examine how psychosocial experiences predict risk for suicidal behavior over time among diverse GMAs and non-GMAs, providing critical evidence to more accurately predict which GMAs have high risk for suicidal behavior as well as to identify novel intervention targets to reduce high rates of suicidal behavior among GMAs.

PI_NAMEs: THOMA, BRIAN  (contact)

PROGRAM_OFFICER_NAME: BURNS, PAUL ANTHONY

PROJECT_TERMS: Adolescence;Adolescent;Advertisements;Affect;Age;behavior change;Birth;boys;Child Abuse;Clinical;Color;comparison group;Data;Discrimination;ethnic identity;Ethnic Origin;Exhibits;experience;Feeling suicidal;follow-up;Frequencies;Gender;gender affirming hormone therapy;Gender Confirmation Surgery;gender diverse;gender expression;Gender Identity;gender minority;gender minority group;gender minority youth;gender transition;Geographic Locations;girls;health disparity;health disparity populations;health equity;high risk;Inequity;Intervention;Interview;Investigation;Knowledge;Longitudinal Studies;Mediating;Medical;minority stress;minority stressor;Names;National Institute on Minority Health and Health Disparities;nonbinary;novel;Participant;Pathway interactions;peer victimization;Protocols documentation;Psychiatric Diagnosis;psychiatric symptom;psychosocial;Race;racial identity;recruit;Recurrence;Reporting;response;Risk Factors;Risk Marker;risk prediction;Sampling;sex assigned;social;social media;Sterile coverings;Stigmatization;stressor;Subgroup;suicidal behavior;suicidal risk;Suicide;suicide rate;Surveys;theories;Time;transgender;United States National Institutes of Health;virtual

PROJECT_TITLE: Psychosocial Predictors of Risk for Suicidal Behavior Among Gender Minority Adolescents

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Behavioral and Social Science;Chronic Pain;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Osteoarthritis;Pain Research;Physical Activity;Rehabilitation;Rural Health;Social Determinants of Health;Telehealth

PHR: Painful knee osteoarthritis (OA) is prevalent, disabling, and costly and is especially complicated in persons historically marginalized from health care. The means of maximizing the use and outcomes associated with the telemedicine, various knee injections, and outpatient total knee arthroplasty in persons suffering from knee OA receive little study. This project uses computer-based modeling to establish the value of treatment strategies for knee OA and reduce inequities in the use of these treatments, particularly in historically marginalized populations.

PI_NAMEs: LOSINA, ELENA  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: access disparities;Address;Adherence;Adoption;Adrenal Cortex Hormones;Advertising;Affect;Age;American;analytical method;Area;Award;Black Populations;care delivery;care outcomes;Caring;Clinical;Cohort Studies;comorbidity;Computer Models;Computer Simulation;cost;cost effective;cost effectiveness;Cost Effectiveness Analysis;Cost of Illness;Costs and Benefits;Data;Degenerative polyarthritis;digital;disability;Disabling;Disparity;disparity reduction;Economics;Education;Equity;ethnic minority population;Ethnic Origin;Evaluation;evidence base;Exercise;exercise program;experience;Formulation;Funding;Future;General Population;Health;health care delivery;health care disparity;health disparity populations;Health Expenditures;health inequalities;Health Personnel;Health Services Accessibility;Healthcare;Hispanic;Hyaluronic Acid;Improve Access;improved;Inequity;Infrastructure;Injections;innovation;Inpatients;Intervention;Intra-Articular Injections;Knee;Knee Osteoarthritis;knee pain;knee replacement arthroplasty;Lead;literacy;marginalization;marginalized population;Methods;Modeling;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Neighborhoods;Obesity;Outcome;outcome prediction;Outpatients;Pain;Pain management;Paper;Patient Care;Patient Selection;Patient-Focused Outcomes;Patients;Peer Review;Persons;Physical activity;Policies;Policy Analysis;Policy Maker;Population;population health;programs;Provider;Publishing;Race;racial minority population;rapid growth;Research;Residencies;Resources;rural area;Savings;Series;Services;social;social deprivation;Social Environment;social health determinants;Social support;social vulnerability;Standardization;Structure;Technology;Telemedicine;tool;treatment strategy;United States Centers for Medicare and Medicaid Services;uptake;Variant

PROJECT_TITLE: Optimizing the value of pain management in knee OA patients with comorbidities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (90)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: TOLEDO

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF TOLEDO

PHR: Public Health Relevance Statement Drug discovery and production can be greatly accelerated through the invention and development of novel catalysis avenues and chemical reactions. In this context, we outline several generic strategies capable of delivering a range of exceptional chemical reactions to expedite pharmaceutical synthesis. The ability to prepare diverse collections of chiral nitrogen-containing skeletons will advance the understanding of their potential as chemical probes or drug candidates.

PI_NAMEs: LI, WEI  (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TITLE: Halogenase Inspired Chemical Catalysis and Methods

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: HAVERFORD

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: HAVERFORD COLLEGE

PHR: PROJECT NARRATIVE In population genetics, deep neural networks are replacing traditional methods as the most promising frameworks for understanding evolution. However, little is known about which networks work best for different problems, and prediction results are difficult to interpret. The goals of this project are to develop, compare, and understand deep learning methods, allowing us to study evolutionary forces along the genome and across diverse human populations.

PI_NAMEs: MATHIESON, SARA  (contact)

PROGRAM_OFFICER_NAME: ARGUELLO, ALEXANDER

PROJECT_TERMS: Address;Admixture;Algorithms;Architecture;Area;Bayesian Analysis;Black Box;computer science;convolutional neural network;Data;Data Reporting;Data Set;deep learning;deep neural network;Demography;Dependence;design;Development;Ensure;Event;Evolution;Exposure to;Family;feature extraction;flexibility;generative adversarial network;Genetic;Genetic Recombination;Genome;genome-wide;Genomics;Goals;Haplotypes;Historical Demography;Human;Human Engineering;Image;Incentives;Individual;Industry;innovation;insight;Internships;Joints;large language model;Learning;learning strategy;Machine Learning;Methodology;Methods;migration;Modeling;Mutation;Natural Selections;network architecture;neural network;neural network architecture;novel;Outcome;Output;Parameter Estimation;Population;Population Genetics;Population Sizes;Process;Research;Research Personnel;Role;simulation;Site;Sorting;statistics;Students;Testing;Training;training data;Trees;undergraduate student;Work

PROJECT_TITLE: Adaptive evolutionary inference frameworks for understudied populations using generative neural networks


ADMINISTERING_IC: EY

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: PROJECT NARRATIVE These results will demonstrate how visual experience during key developmental windows structures the processing of visual information in the brain to effect behavior. Understanding these basic mechanisms are necessary fundamental steps to develop therapies for many ocular and neurological disorders. Last, this proposal will support diverse student training experiences that will help develop the next generation of biomedical professionals.

PI_NAMEs: HORSTICK, ERIC JAMES (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Address;Amblyopia;Anatomy;Animal Behavior;Animals;Behavior;Behavioral;blind;Brain;Brain region;Brain-Derived Neurotrophic Factor;Calcium;career;cell type;Complex;critical period;Cues;Data;Dedications;Degree program;Development;Environment;Exhibits;experience;Eye diseases;Feedback;Foundations;Functional Imaging;gamma-Aminobutyric Acid;Gene Expression Profiling;Genetic;genetic approach;Goals;hands on research;Human;Image;in vivo;in vivo evaluation;insight;knock-down;Knowledge;Larva;Lazy Eyes;Lighting;Manuscripts;Mediating;Modality;Modeling;Molecular;mutant;Nervous System Disorder;neural circuit;Neurons;neurophysiology;neurotrophic factor;next generation;novel;Optics;Organism;Output;Pattern;Performance;Pharmacology;Physiology;Positioning Attribute;Productivity;Publishing;Reproducibility;Research;Research Training;response;reverse genetics;Role;Sensory;Shapes;Signal Transduction;skills;stem;STEM career;Structure;student training;success;System;Thalamic structure;therapy development;tool;Training;undergraduate student;Vertebrates;Vision;vision development;Visual;Visual Acuity;Visual impairment;visual information;visual motor;visual plasticity;visual processing;visual stimulus;Visual System;Work;Zebrafish

PROJECT_TITLE: Examining how visual experience modulates the thalamus and visuomotor responses.

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: HOUGHTON

ORG_NAME: MICHIGAN TECHNOLOGICAL UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Many people in the US have heart failure and many of them die within a few years. One way to treat heart failure is to use a special device that sends electrical signals to your heart to make it beat better. We want to find better ways to decide who should get this device and where to put the device on the heart.

PI_NAMEs: SHA, QIUYING  (contact)

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: Algorithms;Attention;cardiac resynchronization therapy;Cardiology;cardiovascular imaging;Cardiovascular system;Clinical;clinical decision-making;clinical practice;Computational algorithm;Computers;Data;Decision Making;Dedications;deep reinforcement learning;design;Devices;Education;Educational process of instructing;Electrocardiogram;experience;falls;graduate student;Guidelines;Healthcare;Heart;Heart failure;heart function;Image Analysis;image guided;improved;innovation;interdisciplinary collaboration;Interdisciplinary Study;Knowledge;Knowledge Discovery;Label;Lead;Learning;Left;Left ventricular structure;Machine Learning;Measures;Mechanics;Medical;Medical Imaging;Medical Informatics;Methods;Michigan;Myocardial;Myocardial Contraction;Myocardial perfusion;Outcome;Patient Selection;patient subsets;Patients;Pattern;perfusion imaging;Persons;Positioning Attribute;Process;professor;programs;Psychological reinforcement;Public Health Informatics;Pythons;Recommendation;Relaxation;Research;response;Right ventricular structure;Role;Severities;Signal Transduction;single photon emission computed tomography;Site;standard care;Students;supervised learning;Symptoms;Techniques;translational approach;treatment response;undergraduate research;undergraduate student;Universities;unsupervised learning;Validation;Ventricular;Visual

PROJECT_TITLE: Integrative analysis of electrical and mechanical dyssynchrony to improve cardiac resynchronization therapy

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Dental, Oral, and Craniofacial Disease;Nanotechnology;Rare Diseases

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The 5-year survival rate for head and neck cancer has only modestly improved despite treatment advances, partly due to the lack of effective imaging methods for tumor margins and metastatic lymph nodes assessment during surgery. Our project aims to develop a clinically applicable method using self-illuminating biomarkers, which are highly sensitive and low in toxicity, to enable precise image-guided surgery for head and neck cancer. Implementing this innovative imaging approach holds the potential to significantly enhance treatment outcomes and prognosis for patients with this condition.

PI_NAMEs: LEE, JUNG-JAE  (contact)

PROGRAM_OFFICER_NAME: LOPEZ, ORLANDO

PROJECT_TERMS: Address;Anatomy;Animal Model;Binding;Biological Markers;biomaterial compatibility;Body Surface;Cancer Detection;cancer imaging;Cancer Patient;cancer surgery;cancer survival;cancer therapy;Cancerous;Caring;Chemicals;Chemotherapy and/or radiation;Chitosan;Clinical;clinical application;Clinical Trials;cold temperature;Coupled;cytotoxicity;Detection;Development;Disease;Dissection;effective therapy;Effectiveness;effectiveness evaluation;Ensure;Evaluation;ex vivo imaging;Excision;Exhibits;experimental study;flexibility;Fluorescence;fluorescence-guided surgery;fluorophore;Folic Acid;Future;Goals;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Histopathology;Hour;Image;Image Analysis;image guided;Image-Guided Surgery;imaging approach;imaging biomarker;imaging modality;Imaging Techniques;improved;In Situ;in vivo;in vivo imaging;in vivo optical imaging;innovation;innovative technologies;Lasers;Ligands;Localized Malignant Neoplasm;Location;luminescence;lymph nodes;Magnetic Resonance Imaging;Malignant Neoplasms;Metastatic Neoplasm to Lymph Nodes;Methods;Microscopic;Modeling;molecular imaging;Morbidity - disease rate;mouse model;Mus;nanoparticle;nanoprobe;Near-infrared optical imaging;Neoplasm Metastasis;neoplastic cell;Nodal;Noise;Normal tissue morphology;Operative Surgical Procedures;optical imaging;Optics;Outcomes Research;patient prognosis;Patient-Focused Outcomes;Patients;Penetration;Peptides;Permeability;Play;Positron-Emission Tomography;Postoperative Period;pre-clinical;Predictive Factor;preservation;Process;Production;Property;Quantum Dots;redshift;Research;Resolution;Risk;Roentgen Rays;Role;Safety;Signal Transduction;Site;Specimen;Stimulus;Surgeon;surgery outcome;Surgical margins;survival outcome;Survival Rate;System;Tactile;targeted imaging;Techniques;Temperature;Testing;Thinness;Time;Tissues;Toxic effect;Treatment Failure;Treatment outcome;treatment response;tumor;ultrasound;uptake;Visible Radiation;Visual

PROJECT_TITLE: Body heat activated, storable, near-infrared, self-illuminating nanoprobes for chemiluminescence imaging of cancer

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: SALSBURY COVE

ORG_NAME: MOUNT DESERT ISLAND BIOLOGICAL LAB

ORG_STATE: ME

PHR: PROJECT NARRATIVE The Maine IDeA Network of Biomedical Research Excellence will increase biomedical research capacity and competitiveness in Maine through innovative programs involving researchers at all career stages, from undergraduate to faculty level, which work synergistically to foster research excellence, promote career and institutional development, and enhance the diversity of perspectives in biomedical science. Our Network of private and public institutions works collaboratively to bring rigorous data science approaches to bear on significant biomedical problems, and to build out the biomedical science career pipeline in Maine.

PI_NAMEs: COFFMAN, JAMES A (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Adherence;Advisory Committees;Award;Basic Science;Bioinformatics;Biological;biomedical data science;Biomedical Research;career;career development;Centers of Research Excellence;Clinical Research;Cloud Computing;Collaborations;college;Communication;Communities;community college;Community of Practice;Community Outreach;Complement;Complex;Core Facility;Data;Data Science;Data Science Core;Data Scientist;Development;Discipline;Doctor of Philosophy;Educational workshop;Effectiveness;effectiveness evaluation;Ensure;Evaluation;experience;Exposure to;Facility Accesses;Faculty;faculty research;formative assessment;Fostering;Foundations;Funding;Goals;Grant;Growth and Development function;Health;High School Student;Human;Infrastructure;innovation;Institution;Interdisciplinary Study;interest;Internet;Laboratories;Leadership;Letters;literacy;Maine;Mentors;Mentorship;Mission;multidisciplinary;New England;NIH Program Announcements;Pilot Projects;Play;Principal Investigator;Privatization;Program Development;Program Research Project Grants;programs;Research;research and development;Research Institute;Research Personnel;Research Project Grants;Research Support;Resources;Role;Science;Scientist;Structure;student participation;Students;Talents;Technology;The Jackson Laboratory;Training;Translational Research;undergraduate research experience;undergraduate student;underserved community;Universities;Work;working group

PROJECT_TITLE: The Maine Biomedical Research Network (INBRE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-9 (IN)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Data Science

PROJECT_TERMS: Address;Advisory Committees;aspirate;Award;Benchmarking;Biological;Biomedical Research;Budgets;career;Centers of Research Excellence;Collaborations;Committee Members;Communication;Communities;Community Outreach;Consultations;Data;Data Science;Data Science Core;Development;Discipline;Educational workshop;Effectiveness;Ensure;Evaluation;experience;Faculty;Fellowship Program;formative assessment;Fostering;Goals;Grant;Guidelines;high school;Human Resources;Individual;Infrastructure;innovation;Institution;Interdisciplinary Study;interest;Interest Group;Leadership;Learning;Maine;Medical;meetings;Mentors;multidisciplinary;National Institute of General Medical Sciences;New England;Participant;Policies;Principal Investigator;Process;Program Development;Program Research Project Grants;programs;Reporting;Research;Resource Sharing;Resources;Science;science education;Scientist;Series;Shapes;skills;Specialist;Structure;Students;summer student;symposium;Training and Infrastructure;undergraduate student;underserved community;United States National Institutes of Health;Work

PROJECT_TITLE: Administrative Core


PI_NAMEs: UPDIKE, DUSTIN LYNN (contact)

PROJECT_TERMS: Advisory Committees;Applications Grants;Award;biomedical data science;Biomedical Research;career;career development;Centers of Research Excellence;cohesion;Collaborations;Committee Members;computer scientist;Data Science;Dedications;Development;Development Plans;early-career faculty;Educational workshop;Effectiveness;Engineering;Ensure;Evaluation;experience;Faculty;Feedback;formative assessment;Fostering;Funding;Funding Opportunities;Genomics;Goals;Grant;innovation;Institution;International;Investigator-Initiated Research;Journals;Maine;meetings;member;Mentors;Mentorship;Microscopy;Modeling;multidisciplinary;New England;Peer Review;Pilot Projects;Principal Investigator;Program Research Project Grants;programs;Progress Reports;Publications;Publishing;Qualifying;Research;research and development;Research Personnel;Research Project Grants;Research Support;Research Training;Resources;response;Scientist;senior faculty;student participation;Students;success;Talents;Technical Expertise;Training;undergraduate student;Use Effectiveness;Work;Writing

PROJECT_TITLE: Developmental Research Project Program


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Networking and Information Technology R&D (NITRD)

PI_NAMEs: GRABER, JOEL H (contact)

PROJECT_TERMS: Address;Advanced Development;Awareness;Bioinformatics;biomedical data science;Biomedical Research;Catalogs;catalyst;Cloud Computing;Collaborations;Communities;Community of Practice;Computational Biology;Computational Technique;computing resources;Consultations;cyber enabled;cyber infrastructure;Data;Data Analyses;Data Engineering;data management;Data Science;Data Science Core;Data Scientist;data sharing;Data Storage and Retrieval;Delaware;design;Development;Disparate;Educational Curriculum;Educational workshop;Ensure;Evaluation;experience;Experimental Designs;Faculty;Faculty Recruitment;Fostering;genomic data;Goals;high throughput technology;Human Resources;Institution;Interdisciplinary Study;Knowledge;large datasets;Maine;Master of Science;Medicine;member;Mentors;Methods;New Hampshire;Play;Postdoctoral Fellow;Program Research Project Grants;programs;Recording of previous events;Reproducibility;Research;Research Activity;Research Infrastructure;Research Personnel;Research Training;Resources;Rhode Island;Role;Scholars Program;Science;science teacher;Scientist;Services;Source;Speed;Strategic Planning;Students;success;Technical Expertise;Technology;Training;Training Activity;undergraduate student;United States National Institutes of Health;Universities;Vermont;Visualization;Work;working group

PROJECT_TITLE: Data Science Core


PI_NAMEs: BONNET, FREDERIC XAVIER (contact)

PROJECT_TERMS: Address;Award;Biomedical Research;Centers of Research Excellence;Collaborations;Communication;Core Facility;cost;dashboard;Data Science Core;Data Scientist;Databases;Development;DNA sequencing;Equipment;Evaluation;Facility Accesses;Focus Groups;Funding;Funding Opportunities;Gene Expression Profiling;geographically distant;Goals;Image;imaging program;innovation;Institution;Instruction;instrument;Interdisciplinary Study;interest;Investments;Knowledge;light microscopy;Link;Maine;Measurable;Microscopy;multidisciplinary;New England;Productivity;Program Research Project Grants;programs;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;searchable database;Services;Specimen;Students;Surveys;Technology;Time;tool;Training;Training Programs;Visit;web page;web site;web-accessible;Work

PROJECT_TITLE: Collaborative Research Resources Core


PROJECT_TERMS: Area;Back;Bacteriophages;Biomedical Research;Chemicals;Collaborations;college;community college;Confocal Microscopy;Darkness;Educational Curriculum;Educational process of instructing;Epoxy Resins;experience;experimental study;Faculty;faculty support;First Generation College Students;Floor;foot;Genomics;Goals;improved;Institution;Interdisciplinary Study;Laboratories;laboratory experience;laboratory facility;Laboratory Research;lectures;Light Microscope;Maine;marine;member;Microbiology;Microscope;Microscopy;Modernization;Modification;Molecular Biology;Motion;particle;Plumbing;Research;Research Activity;research facility;Research Project Grants;Resistance;Science;square foot;standing height;Students;Surface;Thick;Thinness;Training;undergraduate research;undergraduate student;Universities;university student;vibration;Work

PROJECT_TITLE: Alterations and Renovations Core


ORG_CITY: DOVER

ORG_NAME: DELAWARE STATE UNIVERSITY

ORG_STATE: DE

PHR: Interdisciplinary Health Equity Research Center Public Health Relevance Summary Because of the diversity of their faculty and students, and places of trust in the community, HBCUs such as Delaware State University, are strategically poised to make important scientific contributions addressing the serious problem of racial/ethnic health disparities. Support from the RCMI program to establish the Interdisciplinary Health Equity Research Center at DSU will build a capacity for biomedical, behavioral and social research targeting understanding and reducing health disparities. The Center will support early stage investigators to reach the level of research capability competitive for external funding and necessary to pursue discovery science that will translate into improvements in the health status of minority individuals and communities.

PI_NAMEs: GUPTA, SANGEETA ;HARRINGTON, MELISSA A (contact)

PROGRAM_OFFICER_NAME: PATEL, ANURADHA DIPAK

PROJECT_TERMS: Address;African American;Alzheimer's disease diagnostic;Applications Grants;Asian;Awareness;Beds;Behavioral;Behavioral Research;Biological;Biomedical Research;Biometry;burden of illness;career;career development;career networking;Caucasians;Clinical;clinical care;collaborative approach;Collection;Communities;community engagement;community organizations;community partners;contextual factors;Core Facility;COVID-19;COVID-19 pandemic;Data;Delaware;Development;Dissemination and Implementation;Economic Development;Electrophysiology (science);ethnic health disparity;Ethnic Origin;Event;experience;Faculty;falls;Fostering;Funding;Future;Goals;Grant;Health;health care disparity;health determinants;Health Disparities Research;health disparity;health equity;health equity promotion;Health equity research;Health Status;Hispanic;Historically Black Colleges and Universities;Human Resources;human subject;improved;Infrastructure;innovation;Institution;Institutional Review Boards;interdisciplinary collaboration;Interdisciplinary Study;Intervention;Lead;Link;literacy;Low income;meetings;member;Mentors;Mentorship;Microscopy;mid-career faculty;minority communities;Minority Groups;molecular diagnostics;Native Americans;Neighborhoods;next generation;Nursing Research;Outcome;outcome disparities;Outcomes Research;Patient Education;Patient-Focused Outcomes;Pilot Projects;Population;Positioning Attribute;Process;programs;public health relevance;Qualitative Methods;Qualitative Research;Race;racial diversity;racial health disparity;racial population;RADx Underserved Populations;Recording of previous events;recruit;Reduce health disparities;Reporting;Research;research and development;Research Personnel;Research Project Grants;Resources;Rural;SARS-CoV-2 infection;Science;Scientist;Scourge;Secure;social;social health determinants;Socioeconomic Status;Structure;Students;Targeted Research;Testing;Training;Translating;Translational Research;Trust;Underrepresented Minority;Underrepresented Populations;underserved community;Underserved Population;United States;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Interdisciplinary Health Equity Research (IHER) Center


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Microbiome

ORG_CITY: IOWA CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Candida albicans is the most common human fungal pathogen and affects both immunocompetent and immunocompromised people. Understanding how C. albicans converts from a normal part of the microbiome to a pathogen is important for identifying new ways to treat infections. Here, we propose to comprehensively characterize genes that regulate the first two steps in the C. albicans pathogenic cycle using novel in vivo tools and infection models.

PI_NAMEs: FILLER, SCOTT G;KRYSAN, DAMIAN J (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Affect;anti-fungal agents;Area;Bar Codes;Biological Assay;Blood Circulation;Blood Vessels;Candida albicans;candidate identification;candidemia;Cell surface;Collection;Complement;Coupling;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;Development;Disease;drug development;Epithelial Cells;Epithelium;Filament;fitness;gastrointestinal;gene discovery;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic analysis;Genetic Screening;Genetic Transcription;Genitourinary system;Goals;Human;Image;Immunity;Immunocompetent;Immunocompromised Host;Impairment;In Vitro;in vivo;Individual;Infection;insight;Invaded;Lead;Libraries;Life;Link;Maintenance;Mediating;Medicine;Methods;microbiome;Modeling;Morphogenesis;mouse model;Mucous Membrane;mutant;mycobiome;nano-string;novel;Oral;Organ;oropharyngeal thrush;pathogen;Pathogenesis;pathogenic fungus;Pathogenicity;Pathway interactions;Patients;Penetration;Persons;Protein Kinase;Regulation;Role;Sepsis;Signal Pathway;Site;Submucosa;Surface;Tail;therapeutic target;Tissues;tool;trait;transcription factor;transcriptome sequencing;Veins;Virulence;Vulvovaginal Candidiasis

PROJECT_TITLE: Regulation of Candida albicans Pathogenesis by Protein Kinase and Transcription Factor Networks

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

PHR: Projective Narrative  Our objective in this project is to provide targeted treatment for neuroinflammation in brain cells by delivering anti-inflammatory agents directly to mitochondria. This innovative approach has the potential to reduce neuroinflammatory processes, promote neuroprotection, and ultimately enhance the quality of life for those with neurological disorders.

PI_NAMEs: BI, LANRONG  (contact)

PROGRAM_OFFICER_NAME: DARINGER, NICHOLE MARIE

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Anti-Inflammatory Agents;Area;Biomedical Research;Blood - brain barrier anatomy;Brain;brain cell;Brain Injuries;Cell Physiology;cell type;Cells;Cellular biology;Central Nervous System;cytokine;Data;design;Disease;dosage;Dose;Education;effective therapy;Effectiveness;effectiveness evaluation;effectiveness study;engineered exosomes;Ensure;Enzyme-Linked Immunosorbent Assay;exosome;experimental study;extracellular vesicles;Foundations;Future;Gene Expression;Genes;glial activation;Goals;Human;Immunofluorescence Immunologic;Immunohistochemistry;improved;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;innovation;insight;intercellular communication;Knowledge;Ligands;Link;Measures;Messenger RNA;Methods;MicroRNAs;Mitochondria;mitochondrial dysfunction;Molecular Biology Techniques;Monitor;multidisciplinary;Nervous System Disorder;neuroinflammation;Neurons;neuroprotection;neurovascular unit;Oxidative Stress;Parkinson Disease;Peripheral;Pharmaceutical Preparations;Phase;Play;Population;preclinical study;primary outcome;Process;Production;Property;Quality of life;Rattus;Research;Resolution;response;Rhodamine;Rodent Model;Role;Safety;Scientist;side effect;skills;student training;Students;Surface;targeted treatment;Therapeutic;Therapeutic Effect;Time;Toxic effect;Training;treatment duration;Treatment Efficacy;Vesicle;Western Blotting;Work

PROJECT_TITLE: Mitochondrial-targeting Exosomes for Neuroinflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-X (81)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Precision Medicine

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE SYNGAP1-DEE is a rare genetic disorder that impacts mental health and behavior through impairments in intellectual and social adaptive functioning. There are no effective treatments for impairments in mental health and behavior in this patient population. In this U01 project, we will develop primary and secondary lead small molecules into preclinical drug candidates designed to treat all aspects of this disorder.

PI_NAMEs: KAMENECKA, THEODORE M;MILLER, COURTNEY A (contact);RUMBAUGH, GAVIN R

PROGRAM_OFFICER_NAME: BRADY, LINDA S

PROJECT_TERMS: Adverse effects;Affect;Animal Model;autism spectrum disorder;Automation;Automobile Driving;Behavior;Behavioral;Biological Products;Biology;Brain;brain cell;brain tissue;Caregivers;Central Nervous System;Chemical Agents;Chemical Structure;Chemicals;Clinical Research;cognitive enhancement;design;Development;Diagnosis;Disease;Distress;Dose;drug candidate;Drug Kinetics;effective therapy;efficacy evaluation;Ensure;Epilepsy;Exhibits;Family;Formulation;Fragile X Syndrome;Funding;Gene Expression;Gene Targeting;Genes;Genetic;genetic approach;Genetic Diseases;Goals;Human;Impaired cognition;Impairment;improved;In Vitro;in vivo;individual patient;Intellectual functioning disability;Knowledge;Lead;lead optimization;lead series;Link;Live Birth;Mental disorders;Mental Health;Microsomes;Mission;mouse genetics;Mus;Mutation;National Institute of Mental Health;Nervous System Physiology;Neurodevelopmental Disorder;Neurons;novel;Oral;Outcome;Pathogenicity;Pathway interactions;patient population;Patients;Penetrance;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pharmacology;Phenotype;pre-clinical;Precision therapeutics;preclinical development;Preclinical Drug Development;Prevalence;Property;protein expression;Proteins;Quality of life;rare genetic disorder;Reporting;Research;Research Project Grants;Risk;Safety;scaffold;scale up;screening;Seizures;small molecule;small molecule libraries;social;Solubility;SYNGAP1;Technology;Testing;Variant;Vertebral column;Work

PROJECT_TITLE: Preclinical development of a precision therapy for a monogenic mental health disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-R (02)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Nutrition;Prevention;Social Determinants of Health

ORG_CITY: AMHERST

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: NARRATIVE Food insecurity, defined as limited or uncertain access to adequate food for an active, healthy life, is reported by nearly one third of adults with cardiovascular disease in the United States and is associated with increased 10-year cardiovascular disease risk and increased risk of death. Current interventions do not address poverty as an underlying driver of food insecurity and do not target long-term CVD risk reduction, especially in African Americans. This study will test a novel, multi-component intervention that includes three components: 1) monthly income supplementation; 2) weekly structured incentive for the purchase of healthy food options; and 3) evidence-based telephone delivered CVD risk reduction education and skills training in African Americans with food insecurity.

PI_NAMEs: WALKER, REBEKAH J (contact)

PROGRAM_OFFICER_NAME: ROUSSOS, GINA PATIENCE

PROJECT_TERMS: Address;Adult;African American;African American population;Age;aged;Area;Behavior;behavior change;behavioral economics;Blood Pressure;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cessation of life;Chronic;cohort;Communities;Consumption;cost;cost effective;cost effectiveness;Data;Diabetes Mellitus;dietary;Disease Outcome;Education;efficacy testing;Equation;ethnic minority;evidence base;experience;farmers markets;financial incentive;Food;Food Access;food insecurity;Food Supplementation;Glycosylated hemoglobin A;Health;Health behavior;health care service utilization;Health Food;Healthy Eating;Home;improved;improved outcome;Incentives;Income;indexing;Individual;Intervention;intervention effect;Life;Lipids;Living Standards;Measures;Mediator;Mental Health;Morbidity - disease rate;mortality;mortality risk;multi-component intervention;novel;Outcome;Participant;Patients;perceived stress;Persons;physical conditioning;Pilot Projects;Population;Poverty;primary outcome;program costs;Quality of life;Randomized;Reporting;Research;Resources;Risk;Risk Factors;Risk Reduction;Security;sex;skills training;Socioeconomic Status;Structure;Study Section;Supermarket;Supplementation;telephone delivery;Testing;Training and Education;treatment as usual;United States;United States Department of Agriculture;voucher

PROJECT_TITLE: Cardiovascular Risk Reduction for Adults with Food Insecurity Using Structured Incentives (CVD-FIT)

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Opioid overdoses and deaths continue to increase while access to medications for opioid use disorder continue to be underutilized nationally and in the Seattle area. We propose to use an intensive data to action framework to guide rapid data infrastructure, medical, treatment, and public health improvements. The primary outcomes are to test the impact of the stabilization center on decrease in acute care utilization (EMS, ED), morbidity, mortality, incarceration, housing insecurity, and public agency costs.

PI_NAMEs: BANTA-GREEN, CALEB  (contact);HOOD, JULIA ELIZABETH

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: Accident and Emergency department;acute care;Area;behavioral health;care delivery;care systems;Caring;Case Management;Clinical;Clinical Protocols;Communities;Continuity of Patient Care;cost;Cost-Benefit Analysis;County;Data;Data Analyses;data dashboard;data hub;data infrastructure;data integration;data management;Data Sources;Death Rate;Decision Making;Development;Drug user;Equity;Fentanyl;Fire - disasters;Grant;Harm Reduction;Health;health care service utilization;Health Personnel;Health Services Accessibility;Healthcare;high risk;Housing;Imprisonment;Improve Access;improved;improved outcome;Inequity;Information Systems;Infrastructure;Intervention;Jail;Measurable;Medicaid;Medical;Medical Examiners;medication for opioid use disorder;Mental Health;Monitor;Morbidity - disease rate;mortality;multidisciplinary;naloxone dispensing;Opioid;opioid mortality;opioid overdose;opioid use disorder;Outcome;outreach;Overdose;overdose death;person centered;Persons;Phase;primary outcome;Process;process improvement;programs;Provider;Public Health;Recovery Support;Reporting;Research;Resources;response;retention rate;service delivery;service gap;Services;Substance Use Disorder;supported housing;System;Testing;Time;tool;treatment services;Universities;Visualization;Washington;Work

PROJECT_TITLE: Using data to drive action to reduce opioid overdoses in Seattle, WA


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Emergency Care;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric

ORG_CITY: NEW YORK

ORG_NAME: PACE UNIVERSITY NEW YORK

PHR: Safety events are prevalent in prehospital pediatric care, potentially resulting in childhood morbidity and mortality. Enhancing emergency care for pediatric patients in the out-of-hospital setting is of paramount importance and holds great societal benefits, as it has the potential to significantly improve patient outcomes and reduce healthcare costs. The objective of this research is to design, develop, and evaluate an evidence- based, context-sensitive cognitive aid to assist prehospital providers in recognizing patients' requirements and delivering timely interventions for the treatment and stabilization of pediatric patients in the field.

PI_NAMEs: ZHANG, ZHAN  (contact)

PROGRAM_OFFICER_NAME: FARRELL, CATHERINE MARY

PROJECT_TERMS: absorption;acute care;Address;Adherence;Adopted;Area;Artificial Intelligence;Back;Categories;Child Care;Child health care;Childhood;Childhood Injury;Clinical;Cognitive;cognitive load;Collaborations;Communication;computer human interaction;Consumption;Critical Thinking;Data;Data Analyses;design;Development;digital;digital health;educational atmosphere;Electronic Health Record;Emergency Care;Emergency Medical Technicians;empowerment;Environment;Evaluation;Event;evidence base;experience;Fatigue;Fostering;Frequencies;Goals;Health Care Costs;health care service;Health Technology;Hospital Administration;Hospitals;human-in-the-loop;improved;innovation;insight;Intervention;Knowledge;Medical;Medical Errors;Medical Informatics;Medication Errors;Mentors;Modeling;Morbidity - disease rate;mortality;Natural Language Processing;novel;Paramedical Personnel;patient safety;Patient-Focused Outcomes;Patients;pediatric emergency;Pediatric Hospitals;pediatric patients;Phase;point of care;Pre-hospitalization care;pressure;Process;Protocols documentation;prototype;Provider;Psyche structure;Recommendation;Records;recruit;Recurrence;Research;Research Activity;Safety;service delivery;simulation;skills;Standardization;Student recruitment;Students;Suggestion;support tools;System;Task Performances;Techniques;Technology;Testing;Time;tool;Training;undergraduate student;United States National Institutes of Health;usability;user centered design;user-friendly;Work

PROJECT_TITLE: Design and Development of an Evidence-based Cognitive Aid for Out-of-Hospital Treatment of Pediatric Patients

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]