ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARATIVE The UAB Building and InnovatinG: Digital heAlth Technology and Analytics (BIGDATA) Core Center for Clinical Research (CCCR) encompasses three distinct and synergistic cores (Administrative, Methodologic and Health Informatics [MHI], and the Dissemination, Implementation and Community Engagement [DICE] Resource Core) aligned around the theme of big data and real-world evidence that spans the continuum of research. BIGDATA harnesses informatics, digital health tools, and advanced analytics in pursuit of its theme and sub- theme of health equity and community engagement. The goal of the BIGDATA CCCR is to bring the innovative research and technology tools necessary to transform healthcare in the 21st century and to improve outcomes for patients with rheumatologic and musculoskeletal diseases.

PI_NAMEs: CURTIS, JEFFREY R. (contact)

PROJECT_TERMS: advanced analytics;Advisory Committees;Alabama;American;ARHGEF5 gene;Artificial Intelligence;Award;base;Big Data;Biomedical Research;Biometry;Businesses;Center for Translational Science Activities;Clinical;clinical center;Clinical Immunology;Clinical Investigator;Clinical Research;Clinical Trials;Collection;college;Communities;community based research;community engagement;community setting;comparative effectiveness;Couples;COVID-19 pandemic;Data;data acquisition;Data Analytics;data visualization;Decentralization;design;Devices;digital health;digital tool;Dissemination and Implementation;Electronic Health Record;Environment;Epidemiology;Fostering;Funding;Future;Genetic;Goals;Health care facility;health disparity;health economics;health equity;Health equity research;health plan;Health Technology;Healthcare;Immunologics;implementation research;implementation science;improved outcome;Individual;Industry;Informatics;innovation;Institution;Link;Machine Learning;medication safety;Medicine;Methodology;Methods;mHealth;Mission;mobile computing;multidisciplinary;Musculoskeletal Diseases;Names;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Natural Language Processing;patient engagement;patient oriented;patient oriented research;patient registry;Patient-Focused Outcomes;Patients;practice-based research network;pragmatic trial;Process;prospective;Public Health Informatics;recruit;Registries;Research;Research Activity;Research Personnel;research to practice;Resources;Rheumatism;rheumatologist;Rheumatology;Role;Science;smartphone application;social media;Structure;success;Technology;Testing;tool;Training;Translating;Translational Research;translational research program;translational scientist;Underrepresented Populations;Universities;virtual reality;Voice;wearable sensor technology


ADMINISTERING_IC: AR

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Dissemination and Implementation Research;Networking and Information Technology R&D (NITRD)

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

PROJECT_TERMS: Address;Advisory Committees;Alabama;Area;Arthritis;base;Big Data;Biometry;career;Caring;Clinical;clinical center;Clinical Informatics;Clinical Research;Clinical Sciences;Communities;community engagement;computer science;Consultations;Data;design;Development;digital health;dissemination science;Education;Electronic Health Record;Ensure;Environment;Epidemiology;Evolution;experience;Fostering;Funding;Future;Goals;health equity;Health Technology;imaging informatics;implementation science;improved;Informatics;Infrastructure;innovation;Institution;Knowledge;knowledge translation;Leadership;Measures;member;Methodology;Methods;Minority Groups;Mission;mobile application;Musculoskeletal;Musculoskeletal Diseases;National Center for Advancing Translational Sciences;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;novel;Outcomes Research;patient engagement;Patient Outcomes Assessments;Patient Recruitments;Patients;Performance;Persons;Policy Maker;practice-based research network;programs;Provider;Public Health Informatics;Reporting;Research;Research Personnel;Research Project Grants;Resources;Rheumatism;Rheumatology;Science;Services;skills;Skin;skin disorder;statistics;Technology;tool;Translational Research;Universities;Visualization;wearable device;Work

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZAR1 KM (M1)]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Bioengineering;Comparative Effectiveness Research;Data Science;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: MEHTA, TAPAN S (contact)

PROJECT_TERMS: Address;Affect;American;analytical method;Apple watch;Awareness;base;Bayesian Modeling;Behavioral;Biometry;Caring;Chronic;clinical care;Clinical Data;Clinical Informatics;clinically relevant;Collaborations;Collection;college;community based practice;community engagement;community setting;Computer software;Consultations;cost;Coupled;Custom;Data;Data Analyses;Data Collection;Data Engineering;data integration;data mining;data registry;data resource;Data Sources;data visualization;Decentralization;Deep South;design;Development;digital health;disparity reduction;Effectiveness;effectiveness research;electronic data;electronic data capture system;Electronic Health Record;Engineering;Epidemiology;Evolution;Focus Groups;Fostering;Future;Generations;Goals;Health Benefit;health equity;health goals;Health Technology;Hybrids;implementation research;implementation science;improved outcome;Individual;Informatics;Infrastructure;innovation;Institution;Intervention;Intervention Studies;Interview;Investigation;Knowledge;knowledge translation;large language model;Link;Machine Learning;marginalized population;Medical;Methodology;Methods;Mind;Mission;mobile application;Monitor;multiphase optimization strategy;Musculoskeletal Diseases;Names;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Natural Language Processing;Observational Study;patient oriented;Patient Outcomes Assessments;Patient Preferences;patient registry;Patient-Focused Outcomes;Persons;Physiological;practice-based research network;pragmatic study;Prospective, cohort study;Public Health;Public Health Informatics;Randomized;randomized, clinical trials;Reasons for Geographic And Racial Differences in Stroke;recruit;Registries;Research;Research Design;Research Personnel;Research Support;Research Training;Resources;Rheumatism;Rheumatology;routine care;Sample Size;Sequential Multiple Assignment Randomized Trial;Services;software development;Software Engineering;Software Tools;Structure;System;Techniques;Technology;tool;training opportunity;Translating;Translational Research;trial design;Underserved Population;unstructured clinical data;virtual;wearable device

PROJECT_TITLE: Methods and Health Informatics Core


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: HIDALGO, BERTHA  (contact)

PROJECT_TERMS: Address;Adoption;Advisory Committees;Advocate;Alabama;Chronic Disease;clinical center;Clinical Research;clinical trial recruitment;Collaborations;Communication;Communities;community based participatory research;community engagement;Consultations;Data Collection;Dedications;Deep South;demographics;digital;digital data;digital health;digital platform;Dissemination and Implementation;dissemination science;dissemination strategy;electronic consent;Enrollment;Ensure;Equity;Ethnic Population;evidence base;Evidence based intervention;experience;Fostering;Foundations;Funding;Goals;Health;health disparity;health equity;Health equity research;Health Technology;Hybrids;implementation science;improved;improved outcome;Individual;Informatics;informatics tool;innovation;Intervention;Knowledge;low socioeconomic status;marginalized population;Media Campaign;Methodology;Methods;Mission;multidisciplinary;Musculoskeletal Diseases;National Center for Advancing Translational Sciences;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;novel;novel strategies;online community;online registry;Outcome;patient navigation;Patient Recruitments;Patient-Focused Outcomes;Patients;Persons;Population;Population Heterogeneity;practice-based research network;Public Health Informatics;racial population;Recommendation;recruit;Research;Research Design;Research Personnel;Research Project Grants;research study;Resources;response;Rheumatism;Rheumatology;Role;Rural;Rural Population;Scientist;Services;skills;social health determinants;social media;Testing;theories;Training;Training Programs;Translating;trend;Underrepresented Populations;Universities;Urban Population;virtual;Work

PROJECT_TITLE: Dissemination and Implementation for Community Engagement


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: INDIANAPOLIS

ORG_DEPT: NEUROSURGERY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: The underlying mechanisms and neurological function of reactive astrocyte proliferation after traumatic brain injury are unclear. Our preliminary data suggests that transiently increased expression of platelet-derived growth factor receptor alpha (PDGFR) is required for the reactive astrocyte proliferation post-trauma and the inhibition of this process worsens synapse loss. We will therefore study the PDGFR signaling pathway that underlies the reactive astrocyte proliferation following TBI and explore proliferative reactive astrocytes’ neuroprotective function on counteracting synapse loss and enhance synaptogenesis in order to find novel therapeutic targets for TBI treatment.

PI_NAMEs: GAO, XIANG  (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Ablation;Address;Affect;Agonist;Astrocytes;astrogliosis;Biological Process;Brain Injuries;Brain-Derived Neurotrophic Factor;Cell Proliferation;Cells;conditional knockout;Data;density;Electron Microscope;Foundations;FRAP1 gene;Functional disorder;functional improvement;functional outcomes;Gene Expression;Glial Fibrillary Acidic Protein;Goals;Grant;Hippocampus;Hypertrophy;improved;inhibitor;injured;Injury;innovation;Intervention;Knock-in;Knockout Mice;Knowledge;Label;LoxP-flanked allele;Mediating;Molecular;Morphology;mouse model;mTOR Signaling Pathway;Mus;Natural regeneration;Nervous System Physiology;Neurologic Dysfunctions;neuroprotection;new therapeutic target;novel;overexpression;Pathologic;PIK3CG gene;Platelet Activation;Platelet-Derived Growth Factor alpha Receptor;Play;post-trauma;preservation;Process;Proliferating;Reaction;Research;Role;Signal Pathway;Signal Transduction;Sirolimus;Site;small molecule;Structure;Synapses;synaptogenesis;targeted treatment;TBI treatment;Techniques;Testing;Therapeutic Intervention;Time;tool;Trauma;Traumatic Brain Injury;Virus Diseases

PROJECT_TITLE: The neuroprotective role of proliferative reactive astrocytes in the hippocampus, synapse preservation and regeneration following traumatic brain injury

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE The pain and loss of function that results from rheumatic and musculoskeletal diseases (RMDs), combined with their high prevalence, contributes to substantial disability in the population. Among RMDs, osteoarthritis (OA) is the most common form of arthritis and a leading cause of pain and disability among older adults worldwide. Our Center, focused on optimizing clinical studies in OA and other RMDs through advanced methodologic approaches including phenotyping and precision medicine and broad subject area expertise, will have a sustained impact on the field by enhancing and enriching high quality, innovative studies to improve the understanding of disease mechanisms and targeted interventions for prevention and treatment of OA and other RMDs.

PI_NAMEs: CALLAHAN, LEIGH FLEMING;NELSON, AMANDA E (contact)

PROGRAM_OFFICER_NAME: GREEN PARKER, MELISSA C

PROJECT_TERMS: Address;Adult;Affect;analytical method;analytical tool;Area;Arthritis;Artificial Intelligence;Back Pain;big data management;Bioinformatics;burden of illness;Catalogs;Clinical;clinical care;clinical center;clinical implementation;Clinical Research;Clinical Trials;Clinical Trials Design;Communities;Consultations;Data;data resource;Data Science;Data Set;Degenerative polyarthritis;design;Development;disability;Disease;Disease Management;disorder subtype;Education;effective therapy;Ensure;epidemiologic data;Etiology;Evaluation;experience;Foundations;Genetic;Goals;Health;Health system;High Prevalence;improved;Individual;innovation;International;international center;large datasets;Leadership;loss of function;Lupus;Machine Learning;Malignant Neoplasms;meetings;member;Methodology;Methods;Mission;Monitor;Musculoskeletal Diseases;Myositis;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;North Carolina;novel;novel strategies;Observational Study;older adult;Pain;Patients;personalized management;Phenotype;Population;Population Heterogeneity;precision medicine;preventive intervention;Prognosis;programs;Public Health;Rare Diseases;Research;Research Activity;Research Design;Research Personnel;Resources;Rheumatism;Services;Societies;Strategic Planning;Sum;Surveys;Techniques;Training and Education;treatment response;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: UNC Core Center for Clinical Research


NIH_SPENDING_CATS: Aging;Arthritis;Osteoarthritis

PI_NAMEs: NELSON, AMANDA E (contact)

PROJECT_TERMS: Arthritis;Clinical;Clinical and Translational Science Awards;clinical care;clinical center;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communication;Communities;cost;Degenerative polyarthritis;Department chair;Development;Doctor of Philosophy;Ensure;Evaluation;Funding;Goals;Grant;Health Priorities;Healthcare;Home;Individual;innovation;International;Leadership;Letters;Link;Medical;medical schools;Medicine;meetings;member;Methodology;Mission;Musculoskeletal Diseases;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;North Carolina;novel;outreach;Persons;Phenotype;precision medicine;Privatization;programs;Public Health;Public Relations;Research;Research Activity;Research Personnel;Resources;Rheumatism;Schools;Services;Structure;success;Translational Research;Universities;Vision;Work

PROJECT_TITLE: The UNC Core Center for Clinical Research: Admin Core


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Data Science;Machine Learning and Artificial Intelligence;Precision Medicine

PI_NAMEs: SCHWARTZ, TODD A (contact)

PROJECT_TERMS: Address;Area;Arthritis;Biological Markers;Biometry;career;Clinical;clinical center;Clinical Research;Clinical Trials;Collaborations;Communities;Complex;Consultations;data integration;Data Science;Data Set;Degenerative polyarthritis;design;Development;disability;Disease;Disease Progression;Dissemination and Implementation;Education;Educational Materials;Epidemiologic Methods;Epidemiology;Event;experience;Fostering;Foundations;Funding;Goals;high dimensionality;Image;improved;Individual;Infrastructure;innovation;Institution;International;large scale data;Learning;Logistics;Machine Learning;medical schools;Mentors;Methodology;Methods;Modeling;multidisciplinary;Musculoskeletal Diseases;North Carolina;Onset of illness;optimal treatments;Outcome;Pain;Patients;personalized care;Phase;Phenotype;Positioning Attribute;precision medicine;Process;Public Policy;Research;Research Methodology;Research Personnel;Resources;Rheumatism;Sample Size;Schools;Seminal;Series;Services;social health determinants;Source;Statistical Data Interpretation;Statistical Methods;supervised learning;symposium;synergism;therapy development;Time;Training;Training and Education;training opportunity;treatment response;treatment strategy;trial design;Universities;unsupervised learning;webinar;Work;working group

PROJECT_TITLE: The UNC Core Center for Clinical Research: Methodology Core


NIH_SPENDING_CATS: Aging;Arthritis;Autoimmune Disease;Data Science;Osteoarthritis;Precision Medicine

PROJECT_TERMS: Address;Adverse event;adverse outcome;analytical tool;Area;Arthritis;Back;Big Data;Classification;Clinical;clinical center;Clinical Data;Clinical Research;Clinical Trials;Code;cohort;Collaborations;Communities;Consult;County;Data;Data Collection;data de-identification;data pipeline;Data Science;Data Set;Databases;Degenerative polyarthritis;design;Development;Diagnosis;diet and exercise;disability-adjusted life years;Disease;Disease Management;disease phenotype;Education;effective therapy;experience;Foundations;Future;General Population;Goals;Health;Heterogeneity;Image;implementation barriers;improved;innovation;insight;interdisciplinary collaboration;Intervention;Joints;Learning;Legal patent;Lighting;Link;machine learning model;meetings;Metabolic;Methodology;multimodal data;Musculoskeletal Diseases;Neck Pain;Needs Assessment;Nonpharmacologic Therapy;novel;Observational Study;Patient Care;Patient Outcomes Assessments;Patients;personalized management;pharmacologic;Phenotype;Population;practice-based research network;precision medicine;Probability;Process;Publishing;Rare Diseases;Reporting;Research;Research Personnel;Resources;response;Rheumatism;Rheumatoid Arthritis;Risk;Science;Services;Societies;Strategic Planning;Subgroup;success;targeted treatment;therapy development;Time;tool;Training;Training and Education;treatment response;United States National Institutes of Health;Work

PROJECT_TITLE: The UNC Core Center for Clinical Research: Phenotyping and Precision Medicine Resource Core


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Lung

ORG_DEPT: PATHOLOGY

PHR: The proposed studies will demonstrate a role for neutrophil derived EVs expressing proteolytic activity, that is resistant to endogenous protective mechanisms, in mediating toxicity after halogen gas exposure. Demonstrating this pathway may lead to the future development of a common therapeutic countermeasure targeting proteases specifically associated with EVs.

PI_NAMEs: GENSCHMER, KRISTOPHER R.;PATEL, RAKESH P. (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Accidents;Acute;Acute Lung Injury;Air;Airway Disease;airway remodeling;alpha 1-Antitrypsin;Binding;Bromine;C57BL/6 Mouse;Cell Death;Cells;Chemical Warfare Agents;Chemicals;Chlorine;chlorine gas;Chronic Lung Injury;Chronic Obstructive Pulmonary Disease;Data;Development;Disease;Dissociation;Dose;Edema;exosome;experimental study;Exposure to;Extracellular Matrix;extracellular vesicles;Female;Fibrosis;Future;Gases;Halogens;In Vitro;in vivo;Industrial Accidents;Inflammation;Injury;insight;Lethal Dose 50;Leukocyte Elastase;Lung;lung injury;male;manufacturing process;Measures;Mediating;Mediator;Military Personnel;Modeling;Morphology;morphometry;Mus;neutrophil;neutrophil elastase inhibitor;new therapeutic target;novel;Pathogenicity;Pathway interactions;Peptide Hydrolases;Pharmacologic Substance;Predisposition;Protamine Sulfate;Protease Inhibitor;Proteins;Pulmonary Emphysema;Rattus;Resistance;Respiratory Failure;Respiratory physiology;Role;Site;Sprague-Dawley Rats;Surface;Testing;Therapeutic;Toxic effect;vesicular release

PROJECT_TITLE: Role of proteolytic extracellular vesicles in halogen gas dependent chronic lung injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LWJ-D (CA)]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Services;Pediatric;Women's Health Research

ORG_CITY: RICHMOND

ORG_DEPT: PSYCHIATRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE Substance use disorders during pregnancy and the postpartum period pose a significant threat to public health and have long-term, transgenerational effects on maternal and child health. Interventions, grounded in evidence-based clinical and translational sciences, which can be feasibly integrated into patient care practices should be developed to counter this growing health issue. This research proposes to evaluate the current role of doulas in the maternal and child health care continuum from the perspectives of patients, doulas, and healthcare providers, with the long-term goal of determining how to most effectively integrate doulas into interdisciplinary care teams to 1) reduce barriers to treatment, 2) improve perinatal outcomes, and 3) provide equitable patient-centered care for pregnant and postpartum populations with substance use disorders.

PI_NAMEs: MOELLER, FREDERICK GERARD (contact)

PROGRAM_OFFICER_NAME: BOUGH, KRISTOPHER J

PROJECT_TERMS: Award;barrier to care;Biometry;Career Mobility;Caregivers;Caring;Child health care;clinical center;clinical implementation;clinical practice;Clinical Research;Clinical Sciences;clinical translation;Collaborations;Common Core;Communities;community engagement;Continuity of Patient Care;Development;Disease;Educational Models;Endowment;Equity;equity, diversity, and inclusion;evidence base;experience;Faculty;Foundations;Funding;Goals;Grant;Growth;Health;Health Personnel;improved;Informatics;insight;Institution;Intervention;life span;Maternal and Child Health;medical schools;member;multiple data types;National Center for Advancing Translational Sciences;next generation;Parents;Patient Care;patient population;Patient-Centered Care;Patients;Performance;perinatal outcomes;Phase;Population;Population Heterogeneity;Postpartum Period;Pregnancy;pregnant;Process;Provider;Public Health;recruit;Research;Research Design;Research Methodology;Research Personnel;Resources;Role;Science;Scientist;Societies;Special Population;Speed;Substance Use Disorder;System;Training;Translational Research;Translations;Universities;Virginia;Work;Workforce Development

PROJECT_TITLE: Wright Regional Center for Clinical and Translational Science


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Cephalosporin antibiotics are commonly used but can result in allergic reactions and anaphylaxis. There is no clear diagnostic approach for cephalosporin-allergic patients, and guidance for the use of other antibiotics in allergic patients is based on side chain chemical similarity and limited skin testing evidence. This project includes a clinical trial and mechanistic studies to optimize the approach to cephalosporin allergy and advance future diagnostics.

PI_NAMEs: BLUMENTHAL, KIMBERLY GOLD (contact);KHAN, DAVID A

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Address;Allergic;Allergic Reaction;Anaphylaxis;Antibiotics;Antibodies;beta-Lactams;Biological;Biology;Cefazolin;Cephalosporins;Characteristics;Chemicals;Clinical;Clinical Trials;Clinical Trials Network;Collaborations;cross reactivity;Development;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic strategy;Diagnostic tests;Double-Blind Method;Drug Hypersensitivity;Epitopes;Evaluation;Exclusion;Future;glycosylation;Goals;Haptens;high risk;Hospitalization;Hypersensitivity;Hypersensitivity skin testing;IgE;Immunoglobulin G;Individual;Mediating;Molecular;Multi-Institutional Clinical Trial;National Institute of Allergy and Infectious Disease;novel;Parents;Participant;Pathway interactions;Patients;Pattern;Penicillin Allergy;Penicillins;Perioperative;Pharmaceutical Preparations;Placebo Control;Practice Guidelines;Predictive Value;primary outcome;Procedures;Process;Reaction;Recording of previous events;recruit;Reporting;Research;Risk;Role;Sensitivity and Specificity;Side;Site;Specialist;Specific qualifier value;Specificity;Structure;Subgroup;Testing;Time;tool;trial design;U-Series Cooperative Agreements;United States;United States National Institutes of Health

PROJECT_TITLE: Optimizing the diagnostic approach to cephalosporin allergy testing (DACAT Trial)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 PT-I (M1)]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Disability Research;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: No change from original application.

PI_NAMEs: GEORGE, JACOB ANTHONY (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TERMS: Bionics;Electromyography;exoskeleton;patient oriented;Rehabilitation Centers;Self-Help Devices;stroke patient

PROJECT_TITLE: Patient-centered rehabilitation and dexterous assistive devices for stroke patients using bionic exoskeletons controlled by non-invasive electromyography


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Clinical Research;Data Science;Diabetes;Disability Research;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative: Subjects in diabetic macular edema (DME) clinical trials in the United States are disproportionately White and male, compared with the population undergoing treatment for DME and limited evidence suggests that minoritized men with greater central macular thickness (CMT) are at risk for vision loss if left untreated. The Health Equity and Access to Leverage Technology for Improved DR Outcomes (HEAL-DR) study seeks to understand the association of optical coherence tomography and CMT, laboratory, and clinical measures for racial and ethnic minority patients for reducing visual impairment using an innovative strategy that incorporates data from the Sight OUtcomes Research CollaborativE (SOURCE). This research will have high impact by providing the health sector and other stakeholders research that will enhance visual risk assessment to better identify minority people at greatest risk for vision loss from undetected and/or worsening disease on a population level to enhance clinical guidelines for high-risk minority populations.

PI_NAMEs: FRENCH, DUSTIN D. (contact);STEIN, JOSHUA D

PROGRAM_OFFICER_NAME: SHOAIBI, AZADEH

PROJECT_TERMS: 18 year old;Academic Medical Centers;Academy;Address;Adult;Advisory Committees;American;American Medical Association;Area;Big Data;Blindness;Blood Pressure;Caring;Centers for Disease Control and Prevention (U.S.);Cessation of life;Characteristics;Clinical;Clinical Data;Clinical Trials;Communities;comorbidity;Data;data platform;data resource;Data Sources;deprivation;Detection;Diabetes Mellitus;diabetic;Diabetic Retinopathy;disability;Disease;Disease Progression;disorder risk;Disparity;Dissemination and Implementation;Distress;economic determinant;Economically Deprived Population;Electronic Health Record;ethnic minority;ethnic minority population;Ethnic Origin;experience;Eye;Fluorescein Angiography;follow-up;Fundus photography;Gender;Glycosylated Hemoglobin;Glycosylated hemoglobin A;Goals;Guidelines;healing;Health;health care disparity;health disparity;health equity;Health Services;Healthcare Systems;high risk;high risk population;Image;improved;indexing;innovation;insight;Intervention;Laboratories;Left;Lifelong disability;Link;macula;macular edema;male;Measures;Medicare;Medicine;Michigan;Minority;Minority Groups;Minority Men;minority patient;Mission;Modeling;mortality;National Eye Institute;ophthalmic examination;Ophthalmologist;Ophthalmology;Optical Coherence Tomography;Outcome;Outcomes Research;Output;outreach;Patients;payment;Persons;Pharmaceutical Preparations;Policies;Population;Prediabetes syndrome;Prevention;Prevention Guidelines;programs;proliferative diabetic retinopathy;Race;racial minority;racial minority population;Reduce health disparities;repository;Research;Research Personnel;residence;response;Retinal Detachment;Risk;Risk Adjustment;Risk Assessment;screening guidelines;Severities;social determinants;social health determinants;Social Values;Technology;Thick;Time;Traction;treatment guidelines;United States;United States Dept. of Health and Human Services;United States National Institutes of Health;Universities;Vision;Visit;Visual;Visual disability;Visual impairment;Vitreous Hemorrhage;Work

PROJECT_TITLE: Health Equity and Access to Leverage Technology for Improved Diabetic Retinopathy Outcomes (HEAL-DR)

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Lupus;Pediatric

ORG_CITY: DURHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Half of adolescents who suffer from pediatric systemic lupus erythematosus do not take medications regularly as prescribed and face high risk of poor health outcomes. Though critically important to health outcomes, non- adherence is often difficult to identify in research and clinical care settings using existing measures. This proposal will use pharmacokinetic model simulations to define a blood concentration predictive of non- adherence, and then develop and pilot test a novel, patient-facing intervention designed to reduce non- adherence in pediatric systemic lupus erythematosus.

PI_NAMEs: RANDELL, RACHEL LEIGH (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: Address;Adherence;Adolescent;adolescent health outcomes;Arthritis;Biometry;Blood;Blood specimen;career;Cessation of life;Childhood;Chronic;clinical care;Clinical Pharmacology;Communication;Data;Dedications;design;digital intervention;disability;Disease;distinguished professor;Doctor of Philosophy;Dose;Drug Kinetics;efficacy testing;efficacy trial;Endowment;Environment;experience;Face;Faculty;Family;feasibility testing;Feedback;Florida;Focus Groups;Funding;Future;Goals;Health;high risk;Home;Hydroxychloroquine;improved;Inflammation;Ingestion;innovation;International;Intervention;K-Series Research Career Programs;Learning;Measures;medication nonadherence;Mentors;Mentorship;Methods;Mobile Health Application;models and simulation;novel;operation;Organ;Outcome;Participant;patient engagement;Patients;Pediatric Research;pediatric rheumatic diseases;Performance;Pharmaceutical Preparations;pharmacokinetic model;pharmacometrics;pilot test;poor health outcome;professor;Property;Publishing;Recommendation;Records;Registries;Research;Rheumatology;Risk;Sampling;satisfaction;simulation;skill acquisition;skills;Structure;Systemic Lupus Erythematosus;Testing;Therapeutic;therapy design;therapy development;Time;Training;Treatment Efficacy;treatment optimization;trial design;Universities

PROJECT_TITLE: Direct-to-family pharmacokinetics intervention for hydroxychloroquine non-adherence in adolescents with systemic lupus erythematosus

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: FAYETTEVILLE

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE

ORG_STATE: AR

PHR: Proper brain function requires neural activity in the cerebral cortex with a broad repertoire of intrinsic timescales, from a few milliseconds to many seconds. Determining the fundamental origins of cortical intrinsic timescales and mechanisms that tune the repertoire of timescales is important for advancing understanding of the brain in health and in brain disorders. The research proposed here meets this challenge by developing new theoretical approaches and user-friendly data analytic tools that holistically account for multiple timescales and applies these tools to gain insight on how the brain changes as we awake from sleep and become alert.

PI_NAMEs: BARREIRO, ANDREA KATHERINE;LY, CHENG ;SHEW, WOODROW L. (contact)

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TITLE: Tunable multi-timescale cortical dynamics: fundamental theory and practical tools

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-F (M1)]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease;Organ Transplantation;Prevention;Regenerative Medicine;Transplantation

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: The goal of the clinical trial proposed in this project is to test whether treating a donor kidney with a drug called Berinert®, that blocks an inflammation pathway, will improve outcomes of patients given a kidney transplant from a donor who died. We will also use blood samples and small pieces of kidney tissue obtained by a biopsy to analyze how the treatment affects the donor kidney after transplantation. If the study is successful, we believe the findings will change the way physicians treat kidney transplant recipients in the future.

PI_NAMEs: HEEGER, PETER SCOTT (contact);JORDAN, STAN

PROGRAM_OFFICER_NAME: HAYES, DEBORAH

PROJECT_TERMS: Abbreviations;Acute;Acute Renal Failure with Renal Papillary Necrosis;Address;Adult;Affect;Allografting;Animal Model;arm;Arteries;B-Lymphocytes;Back;Binding;Biological Assay;Biopsy;Blood specimen;cell regeneration;Cells;Cellular Assay;Cessation of life;Clinical;clinical research site;Clinical Trials;Complement 1 Inactivators;Complement Activation;complement system;Data;Data Coordinating Center;design;Development;Donor person;Double-Blind Method;Early Intervention;Eligibility Determination;End stage renal failure;Endothelium;exosome;experience;Failure;fibrogenesis;Flow Cytometry;follow-up;Foundations;Future;Goals;high dimensionality;high risk;Human;Immunofluorescence Immunologic;Immunology procedure;improved;improved outcome;Incidence;Inflammation;Infrastructure;inhibitor therapy;Injections;insight;Intervention;Ischemia;Jordan;Kidney;kidney allograft;kidney cell;Kidney Transplantation;Laboratories;Link;Living Donors;Mannose Binding Lectin;Multicenter Trials;Mus;National Institute of Allergy and Infectious Disease;Natural regeneration;nonhuman primate;novel;Operating Rooms;optimal treatments;Organ;Organ Donor;Outcome;Pathogenicity;Pathway interactions;Patient-Focused Outcomes;Patients;peripheral blood;Pharmaceutical Preparations;Physicians;pilot trial;Placebo Control;Placebos;post-transplant;pre-clinical;preclinical study;preimplantation;Prevalence;prevent;primary endpoint;prospective;Protocols documentation;Publishing;Randomized;Randomized, Controlled Trials;Recovery;renal artery;reparative process;Reperfusion Injury;Reperfusion Therapy;Research;Saline;Sampling;secondary endpoint;Series;Severities;T-Lymphocyte;Techniques;Testing;Therapeutic;Time;Tissues;transcriptomics;transplant model;Transplant Recipients;Transplantation;Urine;Work

PROJECT_TITLE: Intra-graft C1 esterase inhibitor therapy for deceased kidney transplantation

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 TCB-I (M1)]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Patients attempting to initiate buprenorphine treatment now routinely experience precipitated withdrawal despite waiting for withdrawal symptoms to first emerge, leading many clinicians and patients to recommend a novel strategy called “micro-dosing” or “low-dose” buprenorphine induction. Even though the emerging evidence of low-dose inductions is promising, conventional approaches require splitting the buprenorphine medication, are costly, or utilize formulations prohibited in the United States. We therefore propose to conduct a study to evaluate the safety and feasibility of orally administered buprenorphine as a low-dose induction strategy, which if successful will be the basis for a safe, accessible, and an evidence-based approach to buprenorphine initiation.

PI_NAMEs: SUZUKI, JOJI  (contact)

PROGRAM_OFFICER_NAME: RAMEY, TANYA S

PROJECT_TERMS: Admission activity;Area;bioaccumulation;Biological Availability;Buprenorphine;buprenorphine treatment;Clinical;combat;comparative efficacy;cost;craving;Cross-Over Trials;design;Dose;Drug Kinetics;Ensure;evidence base;experience;feasibility trial;Fentanyl;Formularies;Formulation;Goals;healthy volunteer;Heroin;Hospitals;Hour;Human Volunteers;improved;Incidence;Individual;innovation;Inpatients;Intervention;Intravenous;Laboratories;Laws;lipophilicity;Measures;Methods;Monitor;mortality;Naltrexone;novel;novel strategies;open label;Opiate Addiction;Opioid;Opioid agonist;opioid overdose;opioid use disorder;opioid withdrawal;Oral;Oral Administration;Outcome;Outpatients;Overdose;overdose death;Overdose reduction;Oxycodone;Participant;Patients;Pharmaceutical Preparations;Phase;Physiological;Plasma;Prevalence;prevent;primary outcome;Property;Protocols documentation;public health priorities;Randomized;Randomized, Controlled Trials;Recommendation;Reporting;Research;response;Route;Safety;safety and feasibility;safety study;secondary outcome;side effect;Titrations;United States;Visit;Withdrawal;Withdrawal Symptom;Work

PROJECT_TITLE: Oral buprenorphine as a novel low-dose induction strategy for individuals with opioid use disorder

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Prevention

PHR: Narrative The proposed Summer Program for Academic Research in Cancer (SPARC) includes professional development workshops and summer cancer research experiences in laboratories of the Indiana University Simon Comprehensive Cancer Center for undergraduate students and first year medical students. The main goal of this proposal is to provide mentored, high-quality, cancer-focused research experiences along with didactic and professional development workshops to trainees to guide them for careers in cancer-related fields.

PI_NAMEs: NAKSHATRI, HARIKRISHNA  (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: academic program;Advocacy;anti-cancer research;Benchmarking;Cancer Biology;Cancer Burden;Cancer Control;cancer education;cancer prevention;career;Career Choice;career development;Clinical;Clinical Research;Clinical Trials;college;Communication;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;Country;Dedications;design;Development;Doctor of Philosophy;drug discovery;Education;Educational workshop;eleventh grade;Eligibility Determination;Enrollment;Ensure;Evaluation;Event;experience;Extramural Activities;Funding;Future;Goals;graduate student;high school;High School Faculty;high school program;High School Student;Home;Immunooncology;improved;Indiana;Institution;Intervention;Knowledge;Laboratories;Laboratory Research;Leadership;lectures;Malignant Neoplasms;Manuscripts;Medical;medical schools;Medical Students;meetings;member;Mentors;Methods;Mission;NCI-Designated Cancer Center;next generation;Osteopathic Medicine;outreach;Pathway interactions;Patient Care;peer coaching;Physicians;Postbaccalaureate;Precision therapeutics;Prevention strategy;Principal Investigator;Productivity;Program Evaluation;programs;public health emergency;Questionnaires;Recommendation;Recording of previous events;recruit;Research;Research Personnel;Resource-limited setting;Resources;Scholarship;Science;Scientist;skills;Societies;Source;Structure;student training;Students;success;summer program;summer research;System;Training;Training Activity;tumor;undergraduate education;undergraduate research experience;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;virtual;Writing

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: Narrative Mutations in the NRF2/KEAP1 pathway are commonly found in NSCLC, but targeted therapies for patients with these mutations are lacking. We have identified a novel metabolic liability for cells harboring NRF2 and KEAP1 mutations. This work will define how this liability can be exploited in order to identify opportunities for therapeutic intervention for patients with NRF2 and KEAP1 mutations.

PI_NAMEs: DENICOLA, GINA MARIE (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Agar;Amino Acids;Antioxidants;Applications Grants;Biology;Cancer cell line;Cancer Center;Cancer Model;Cancer Patient;cancer therapy;Cells;CRISPR/Cas technology;Cysteine;Cysteine dioxygenase;Cysteine Metabolism Pathway;cysteine sulfinate;Cystine;Data;disulfide bond;Engineering;Enzymes;epigenetic silencing;Genetic Engineering;Genetically Engineered Mouse;Genets;Glutamates;Glutathione;Glycine;Goals;Growth;Human;hypotaurine;in vivo Model;Investigation;Knock-in Mouse;Lung Adenocarcinoma;lung cancer cell;Lung Capacity;Lung Neoplasms;lung tumorigenesis;Maintenance;Malignant neoplasm of lung;Mediating;Metabolic;Metabolic Control;Metabolism;metabolomics;Methylation;Modeling;mouse model;mutant;Mutant Strains Mice;Mutation;Nature;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;Outcome;Oxidation-Reduction;Oxidative Stress;parent grant;Pathway interactions;Patients;Positioning Attribute;Process;Production;Proliferating;protein expression;Proteins;Reaction;response;restoration;Role;Sampling;Specimen;Sulfites;Sulfur;System;targeted treatment;Taurine;Testing;Therapeutic Intervention;Toxic effect;transcription factor;tumor;tumor initiation;tumorigenesis;TXN gene;uptake;Work;Xenograft Model

PROJECT_TITLE: Investigation of NRF2-Dependent Metabolic Liabilities


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biodefense and Related Countermeasures;Brain Disorders;Dementia;Emerging Infectious Diseases;Eye Disease and Disorders of Vision;Infectious Diseases;Macular Degeneration;Neurodegenerative;Neurosciences;Vector-Borne Diseases

ORG_CITY: MILWAUKEE

ORG_DEPT: BIOPHYSICS

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PUBLIC HEALTH RELEVANCE Proteins involved in innate immunity and host-pathogen interactions play fundamental roles in human health and are major targets for therapeutic drug development. Elucidating their structures will provide important information for advancing medical research 1

PI_NAMEs: MARASSI, FRANCESCA M (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Address;age related;Age related macular degeneration;Alzheimer's Disease;Bacterial Outer Membrane Proteins;Blood Proteins;Cell Adhesion;cell motility;Cell surface;Complement;Deposition;design;Diagnostic;Disease;drug development;Environment;Goals;Health;Hemostatic function;Host Defense;Human;Immunity;Knowledge;knowledge base;Lipids;Medical Research;Membrane Proteins;microbial;multidisciplinary;Natural Immunity;pathogen;Pathogenesis;pathogenic bacteria;pathogenic microbe;Pathologic;Play;Preventive;Process;Proteins;public health relevance;recruit;Research;Research Project Grants;Role;solid state nuclear magnetic resonance;stressor;structural biology;Structure;targeted treatment;Techniques;Therapeutic;Yersinia pestis

PROJECT_TITLE: Membrane Protein Effectors of Pathogen Interactions With Host

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Disability Research;Heart Disease;Machine Learning and Artificial Intelligence

ORG_CITY: ROCHESTER

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: ROCHESTER INSTITUTE OF TECHNOLOGY

ORG_STATE: NY

PHR: PROJECT NARRATIVE  Patients suffering from congestive heart failure due to severe left ventricular systolic dysfunction may require a ventricular assistive device (VAD)—a mechanical pump alternative to cardiac transplantation—to increase cardiac output, which, once implanted, VAD patients are dependent on for their wellbeing, and many become completely dependent on the device’s output for their very survival. The performance of the VAD pump is in part dependent on the physical and functional aspects of the pump itself, but equally important is the moment to moment interaction between the pump and the patient’s native cardiovascular system, and while current generation pumps have internal monitors of pump performance, their capabilities are rudimentary and typically require advanced cardiovascular diagnostics (transthoracic or transesophageal echocardiography) for correlation with patient signs and symptomatology. The goal of this research is to prove advanced acoustic interrogation of the VAD device can provide information related to the physical mechanisms causing the condition that is not currently available to clinicians at the bedside regarding VAD loading conditions and pump performance.

PI_NAMEs: KOLODZIEJ, JASON R (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: Academic Medical Centers;Acoustics;Address;Algorithms;Anastomosis - action;Aorta;aortic valve;Aortic Valve Insufficiency;Apical;Cannulas;Cardiac Output;Cardiovascular system;Categories;Chest;Classification;Clinical;Clinical Data;Complex;Computer software;Computers;Congestive Heart Failure;Custom;Data;data fusion;Data Set;design;Devices;Diagnosis;Diagnostic;digital;Disease;doctoral student;Echocardiography;Electrocardiogram;Electronics;Engineering;Environment;Equipment;Equipment Malfunction;experience;Faculty;Failure;Frequencies;Functional disorder;Funding;Future;Generations;Goals;Health;Health Personnel;Health Status;health training;Heart Rate;heart rhythm;Heart Sounds;Heart Transplantation;Heart Valves;hemodynamics;Hour;Human;Image;Implant;improved;innovation;input device;Institutional Review Boards;invention;Knowledge;Lead;Left;Left Ventricular Function;Machine Learning;machine learning model;mechanical device;Mechanics;Medical Research;Medicine;Methods;Mitral Valve;Mitral Valve Insufficiency;Mitral Valve Stenosis;Monitor;monitoring device;Motor;motor disorder;novel;novel strategies;Outcome;Output;Patient Care;Patients;Performance;Personal Satisfaction;Physiologic pulse;pressure;Procedures;Process;professor;Protocols documentation;Pump;Research;research clinical testing;Research Personnel;Research Project Grants;research study;Running;Self-Help Devices;Severities;signal processing;Signal Transduction;sound;Speed;Stenosis;Stethoscopes;Students;symptomatology;Symptoms;System;Systemic hypertension;Techniques;Technology;Testing;Time;Tissues;Training;Transesophageal Echocardiography;transfer learning;Ultrasonography;ultrasound;undergraduate student;Ventricular;ventricular assist device;voltage;Work

PROJECT_TITLE: Non-invasive Condition Monitoring of Ventricular Assistive Devices Using Automated Advanced Acoustic Methods


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Substance Misuse

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

PHR: Project Narrative In this project, we will apply advanced genomic and bioinformatic technologies to decipher the links among genetics, epigenetics and environmental factors involved in opioid addiction. Such knowledge will help understand the underlying biology of addiction development in general.

PI_NAMEs: BLENDY, JULIE A;LU, CHANG  (contact);WANG, WEI

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: 3-Dimensional;addiction;Address;Adolescence;Adolescent;Adult;Affect;Animals;Behavior;Behavioral;Bioinformatics;bioinformatics tool;Biological Assay;Biology;Brain;Brain region;Cell Nucleus;cell type;Cells;Chromatin Structure;Code;Complex;Cre driver;Data;Development;Disease;DNA Sequence;Drug abuse;Drug Addiction;drug development;Drug Exposure;drug of abuse;drug seeking behavior;Drug Targeting;Drug usage;Enhancers;enhancing factor;Environmental Risk Factor;Epidemic;Epigenetic Process;epigenomics;Exhibits;Exons;Exposure to;Future;gene environment interaction;Genes;Genetic;Genetic Risk;genetic variant;genome wide association study;genome-wide;genome-wide analysis;Genomics;Histones;Human;improved;Incidence;Individual;insight;interest;Knowledge;Life;Life Experience;Link;Literature;Long-Term Effects;Maps;Mediating;Mediation;molecular phenotype;Morphine;mu opioid receptors;Mus;Mutation;Neuronal Plasticity;Neurons;Opiate Addiction;Opioid;opioid exposure;opioid use disorder;Oxycodone;Pathology;Pharmaceutical Preparations;Phenotype;Physiological Processes;Play;Predisposition;Process;promoter;Property;protective allele;Regulatory Element;Resolution;response;reward circuitry;Rewards;Risk;Risk Factors;risk variant;Role;Sampling;Self Administration;Single Nucleotide Polymorphism;Specificity;Stimulus;Substance Addiction;Technology;Testing;Therapeutic;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Validation;Variant;Work

PROJECT_TITLE: Low-input profiling of brain-region and cell-type specific epigenomic dynamics to understand gene-environment interactions in opioid addiction

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE/RELEVANCE Toxic organophosphorus (OP) compounds, ranging from insecticides to chemical warfare agents, pose a persistent threat to human populations in a variety of contexts. We seek to develop a highly effective clinical treatment for OP exposure, based on a modified human butyrylcholinesterase (BChE) enzyme with catalytic degradation activity against nerve agents. Key to this approach is the targeted installation of a hydrolytic zinc site within the BChE active site gorge, which will functionally mimic the active sites of bacterial enzymes with strong OP degradation (hydrolase) activity while retaining the bioavailability of a human enzyme.

PI_NAMEs: SHAFAAT, HANNAH S (contact);WOOD, DAVID W

PROGRAM_OFFICER_NAME: SPRIGGS, SHARDELL M

PROJECT_TERMS: Acetylcholine;Active Sites;Acute;aerosolized;Affinity;analog;Animal Model;Benchmarking;Binding;Binding Sites;Biological Assay;Biological Availability;Blood Circulation;Butyrylcholinesterase;Catalysis;Cells;chemical threat;Chemical Warfare;Chemical Warfare Agents;Clinical;Clinical Treatment;clinically relevant;cofactor;Complement;Computers;Coupled;Data;design;Development;Dose;Drug Metabolic Detoxication;effective therapy;Effectiveness;Emergency Situation;Engineering;Enzymes;Evaluation;Exhibits;Exposure to;Family suidae;Formulation;functional mimics;Future;glycosylation;Goals;Human;Human Engineering;Hybrids;Hydrolase;Hydrolysis;immunogenic;immunogenicity;Inhalation Drug Administration;Insecticides;Intervention;intravenous administration;Libraries;Lung;manufacture;Measures;Metal Binding Site;metalloenzyme;Metals;Methods;microbial;Military Personnel;Modeling;Modification;mutant;Mutation;nerve agent;novel;organophosphate hydrolase;Organophosphates;Organophosphorus Compounds;organophosphorus insecticide;Oximes;Parathion;Pesticides;Point Mutation;Population;Production;Protocols documentation;rational design;Reaction;Recombinants;Safety;Scaffolding Protein;scale up;Serum;side effect;Site;Site-Directed Mutagenesis;standard of care;Structure;success;Techniques;technology development;Testing;Therapeutic;therapeutic enzyme;Transfection;Validation;Work;Zinc

PROJECT_TITLE: Converting human butyrylcholinesterase into a metalloenzyme for catalytic hydrolysis of organophosphates

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-F(54)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Networking and Information Technology R&D (NITRD)

ORG_CITY: BALTIMORE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project narrative Vascular access is the most common medical procedure in the world, with over a billion insertions performed annually. Ultrasound-guided vascular access is increasingly utilized but still has success rate stagnant at 81% primarily due to low contrast resolution, and the unsuccessful cases can develop significant patient discomfort, decreased efficiency, increased costs, and occasionally life and limb threatening complications. To address the enormous problem, we propose a vendor-independent ‘5T (tool tip tracking + tissue typing)-IV’ guidance platform to augment the clinical US imaging guidance.

PI_NAMEs: BOCTOR, EMAD M (contact);KANG, JEEUN ;LESTER, LAEBEN

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: Acoustics;Address;Algorithms;Animal Model;Animals;Arterial Lines;Arteries;Back;Blood;Blood Vessels;Caliber;Cannulations;Cardiac Catheterization Procedures;Cardiac Surgery procedures;Catheters;Classification;Clinical;Communication;Compartment syndromes;Computer software;Consumption;cost;Coupled;Data;Dedications;deep learning;Development;Devices;Elements;experience;experimental study;Extracorporeal Membrane Oxygenation;Extravasation;Failure;Family suidae;femoral artery;Femoral vein;Femur;Fiber;Fiber Optics;Fire - disasters;Frequencies;Generations;Goals;graphical user interface;Histocompatibility Testing;Human;Image;image guided;imaging probe;imaging system;improved;in vivo;Injections;innovation;Interventional radiology;Intravenous;Intuition;invention;Lasers;Legal patent;Life;Light;Limb structure;Link;Location;manufacture;Medical;Methods;millimeter;Monitor;Needles;novel;obese patients;Output;Pain;Patient Care;patient safety;Patients;Pattern;Penetration;Performance;Peripheral;phantom model;Pharmaceutical Preparations;Physiologic pulse;point of care;Positioning Attribute;pre-clinical;Procedures;prototype;Puncture procedure;Resolution;Risk;Secure;soft tissue;Source;spatiotemporal;Structure;success;Surveys;System;Testing;Therapeutic;Thrombophlebitis;Time;Tissues;tool;transmission process;Ultrasonography;ultrasound;United States;usability;Validation;Veins;Vendor;Venous;virtual;Visualization;Work

PROJECT_TITLE: 5T-IV: photoacoustic needle with beacon pulse for ultrasound guided vascular access with Tool-Tip Tracking and Tissue Typing


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Psychosis;Schizophrenia;Serious Mental Illness;Social Determinants of Health;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative: Although the absolute risk of violence among persons with serious mental illnesses (SMI) is small, young people experiencing early psychosis are a subgroup at highest violence risk with estimates that up to one-third of individuals engage in violence. Despite the public health impact of violence in this population, no evidence-based behavioral interventions to reduce violence have been tested. This study will conduct mixed-methods formative research within OnTrackNY, the largest early intervention services (EIS) program in the United States, to adapt and assess the feasibility of a behavioral intervention to reduce violence for young adults with early psychosis.

PI_NAMEs: ROLIN, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: acceptability and feasibility;Adult;Age;Aggressive behavior;antisocial behavior;Area;Award;Behavior;Behavior Therapy;career;Caregiver Burden;Chronic;Client;Clinic;Clinical Trials;Clinical Trials Design;Cognitive Therapy;community setting;Conduct Disorder;convict;Coordinated Specialty Care;critical period;Data;Development;Diagnosis;Diagnostic;early experience;Early Intervention;early psychosis;efficacy testing;Ensure;evidence base;Evidence based intervention;experience;feasibility testing;Forensic Medicine;functional improvement;Goals;Grant;Guidelines;health disparity;Health Services;high risk;Hospitalization;Impairment;Imprisonment;improved;Impulsivity;Individual;Inpatients;Intervention;Intervention Trial;Interview;Life;Manuals;Maps;Matched Group;Mentorship;Methods;Modeling;mortality;National Institute of Mental Health;Nature;New York;non-affective psychoses;Onset of illness;Outcome;Outpatients;Participant;Patients;Pattern;peer;Persons;Physicians;pilot trial;Planning Theory;Population;prevent;Process;Psychiatrist;Psychoses;psychosocial;Psychotherapy;Public Health;Qualifying;Qualitative Methods;Qualitative Research;Quality of life;Randomized, Controlled Trials;Recording of previous events;Research;Research Domain Criteria;Research Personnel;Research Support;response;Risk;Sampling;Schizophrenia;Schools;service delivery;service intervention;service programs;Service setting;severe mental illness;Social isolation;Strategic Planning;Structure;Subgroup;Symptoms;Testing;Therapeutic Intervention;Training;Treatment Efficacy;United States;Violence;violence prevention;violent crime;Work;Writing;young adult

PROJECT_TITLE: YOUNG ADULTS WITH VIOLENT BEHAVIOR DURING EARLY PSYCHOSIS: A MIXED-METHODS ASSESSMENT AND INTERVENTION TRIAL

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: Nashville

ORG_DEPT: PHARMACOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Narrative Lipids are a source of important messengers that regulate health and disease in the body. Our research is focused on identifying novel lipid messengers and to determine how they exert their messaging capacity and how they are changed by the body. We also want to establish how known medications that are used to treat pain and inflammation interfere with the formation and action of the novel lipid messengers.

PI_NAMEs: SCHNEIDER, CLAUS  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Acetylation;Anabolism;Aspirin;Biochemistry;Biological;Cell Physiology;cellular targeting;Cytochrome P450;design;Disease;Eicosanoids;Enzymes;Family;Health;hemiketal;Homeostasis;In Vitro;in vivo;Inflammation;Inflammatory;Investigation;KDR gene;Leukotrienes;lipid mediator;lipidomics;Lipids;Lipoxygenase;LOX gene;Mediating;member;Metabolic;Metabolic Pathway;Metabolism;Modeling;Non-Steroidal Anti-Inflammatory Agents;novel;Pain;Pathway interactions;Pharmaceutical Preparations;Plasma;Platelet Activation;Procedures;Property;Prostaglandin D2;Prostaglandin-Endoperoxide Synthase;Prostaglandins;PTGS2 gene;receptor;Receptor Protein-Tyrosine Kinases;Research;response;Role;screening;Source;Structure;Testing;Thromboxanes;urinary

PROJECT_TITLE: Novel pathways in eicosanoid biosynthesis and metabolism

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: PROJECT NARRATIVE This proposed work addresses a relevant public health concern through advancing health care patient safety by developing novel, artificial intelligence based health information technology (IT) tools to guide critical care pharmacists in preventing medication errors and reducing adverse drug events (ADEs). Critical care pharmacists improve medication safety and patient-centered outcomes in the critically ill but are an underused resource. Therefore, this project is relevant to the AHRQ mission because it will contribute to implementation of health IT tools that can improve health care quality and outcomes through the prediction of ADEs that can be prevented by critical care pharmacists.

PI_NAMEs: SIKORA, ANDREA  (contact)

PROGRAM_OFFICER_NAME: SWIGER, JAMES

PROJECT_TITLE: Artificial intelligence-based health IT tools to optimize critical care pharmacist resources through adverse drug event prediction

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: FARMINGTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Project Narrative Computational modeling, enabled by COPASI and VCell technologies, will offer deep insights into mechanisms by which cells function and the cellular basis of disease. Projects by our user base focused on cancer, neurological disorders, diabetes, kidney disease, cardiology and aging, for example, all utilize mathematical models developed with the aid of VCell and COPASI.

PI_NAMEs: LOEW, LESLIE M (contact);MENDES, PEDRO

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: 3-Dimensional;Aging;Algorithmic Software;Algorithms;base;Benchmarking;Binding;Biochemical Reaction;biophysical model;Biophysical Process;Cardiology;cell community;Cell model;Cell Physiology;Cells;Cellular biology;Characteristics;Cloud Computing;Communities;Complex;Complex Analysis;Computer Models;Computer software;computerized tools;Connecticut;Databases;Diabetes Mellitus;Differential Equation;Diffusion;Disease;Documentation;Education and Outreach;Educational workshop;Electronic Mail;Electrophysiology (science);Equation;experience;experimental study;Geometry;Goals;High Performance Computing;Hybrids;Image;improved;Infrastructure;insight;Institution;International;Joints;Kidney Diseases;Kinetics;Lateral;Maintenance;Malignant Neoplasms;mathematical model;Mathematics;medical schools;meetings;Membrane;Metabolic Control;migration;Modeling;models and simulation;Modernization;Nervous System Disorder;Online Systems;open source;Operating System;organizational structure;Paper;Parameter Estimation;particle;Pathway interactions;portability;Reaction;repository;Reproducibility;Resources;Services;Shapes;simulation;skills;Software Engineering;software systems;Software Tools;Supporting Cell;System;Systems Biology;Technology;technology platform;Testing;Time;tool;Training;Transmembrane Transport;Universities;usability;user-friendly;Validation;virtual;web site;Work

PROJECT_TITLE: Mechanistic Modeling of Cellular Systems


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Genetics

ORG_CITY: LA JOLLA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Bacteria encode a broad range of immune systems that protect individual cells and cell populations from infection by bacteriophages, but whether and how these systems coordinate their activities to fight infections is not known. We will characterize how two transcriptional regulators control bacterial immune system expression in response to DNA damage, and determine whether these regulators enable multiple immune systems to synergistically fight a bacteriophage infection. As antibiotic-resistant bacterial infections rise and bacteriophage therapy becomes more mainstream, this work will aid the rational design of effective bacteriophage therapies that circumvent and/or suppress bacterial immune responses.

PI_NAMEs: BLANKENCHIP, CHELSEA LEE (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Address;Anti-viral Response;antiviral immunity;Bacteria;Bacterial Antibiotic Resistance;Bacterial Genome;Bacterial Infections;Bacteriophages;Binding;Biochemical;Bioinformatics;bioinformatics tool;Biological Assay;Cells;Cellular Stress;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;DNA;DNA Binding;DNA Damage;DNA Repair;DNA Restriction-Modification Enzymes;Escherichia coli;experimental study;fighting;Gene Expression;Generations;Genetic Transcription;Genome;Immune response;Immune signaling;Immune system;Immune Targeting;Individual;Infection;Island;Ligand Binding;Ligands;Mainstreaming;Mediating;Modeling;Modification;Molecular;Molecular Conformation;Mutation;Nucleic Acids;Oligonucleotides;Oranges;pathogen;Periodicity;Plasmids;Population;pressure;Prophages;Proteins;rational design;Regulation;Resolution;response;Role;sensor;Signal Transduction;small molecule;Structure;synergism;System;Testing;transcription factor;Transcriptional Regulation;Viral;Virus;Work;X-Ray Crystallography

PROJECT_TITLE: Molecular mechanisms of bacterial immune signaling through DNA damage

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Complementary and Integrative Health;Digestive Diseases;Mental Health;Neurosciences;Substance Misuse

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative  The perception of gut distension is an interoceptive feeling associated with a number of clinical conditions. However, we still don’t understand how the brain discriminates between distension and nutrient sensing. We will map the circuitry linking the spinal cord to the brain to decipher how gut mechanical signals are perceived.

PI_NAMEs: DE ARAUJO, IVAN E (contact);PERKINS, MATTHEW HUNTOON

PROGRAM_OFFICER_NAME: CHEN, WEN G

PROJECT_TERMS: Ablation;Address;Afferent Neurons;Anatomy;Animals;Anorexia;Area;awake;Behavior;Behavioral;Behavioral Assay;Brain;brain circuitry;Brain Mapping;brain pathway;Cell Nucleus;Cells;Chemicals;Chronic;Clinical;Cognitive;combinatorial;Communication;Computers;design;detection of nutrient;Disease;Electrophysiology (science);Emotional;Esthesia;experimental study;Fatigue;Feeling;FOS gene;Functional disorder;Ganglia;gastrointestinal;Gastrointestinal Motility;gut-brain axis;in vivo;Injections;Interoception;Lateral;Light;Link;Maps;mechanical signal;mechanical stimulus;Mechanics;Mechanoreceptors;mechanotransduction;Mediating;Methodology;Microscopy;Molecular;motility disorder;Mus;Musculoskeletal;Nausea;nerve supply;Nervous System Disorder;neural circuit;Neurons;Neurosciences;novel;Opsin;Optics;optogenetics;Organ;Parietal;Pathway interactions;Perception;Peripheral;Physiological;Play;pressure;Proprioception;psychologic;psychosocial;receptor;Reticular Formation;Rewards;Role;Satiation;Sensory;Sensory Ganglia;Signal Transduction;Source;Spinal;Spinal Cord;Spinal Ganglia;Spinal Manipulation;Stimulus;Stomach;Stretching;Substance abuse problem;Testing;therapeutic target;Tracer;Vagus nerve structure;Viral

PROJECT_TITLE: Spinal Sensory Ganglia and Gut Sensation


ORG_CITY: PORTLAND

ORG_NAME: PORTLAND STATE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE. The Dpd restriction-modification (RM) system is a newly discovered RM system widely distributed in bacteria and based on the formation of 7-deazaguanosine derivatives in DNA. The work described in this proposal will lead to a molecular-level understanding of the roles of the Dpd proteins in complex DNA modification, and lay a foundation for the development of new biotechnological tools.

PI_NAMEs: IWATA-REUYL, DIRK  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: 7-deazaguanine;Address;Archaeal Viruses;ATP phosphohydrolase;ATPase Domain;Bacteria;Bacteriophages;base;Biochemical;Biochemistry;Bioinformatics;biological systems;biophysical techniques;Biotechnology;Chemicals;Chemistry;Complex;Development;Discipline;DNA;DNA Modification Process;DNA Restriction-Modification Enzymes;Elements;Engineering;enzyme structure;Enzymes;Epigenetic Process;epigenetic regulation;Experimental Designs;Family;Foundations;Future;Genetic;Genome;In Vitro;in vivo;innovation;Interdisciplinary Study;Joints;Knowledge;Lead;Microbial Genetics;Modeling;Modification;Molecular;Molecular Biology;Nitriles;novel;nuclease;Nucleic Acids;nucleobase;Nucleoside Q;Nucleosides;Nucleotides;Organism;Organism Modification;Positioning Attribute;Prevalence;Process;Productivity;Proteins;Publications;Reaction;Research;Research Methodology;Research Project Grants;RNA;Role;Site;Specificity;structural biology;Structure;System;tool;Viral;viral DNA;Work

PROJECT_TITLE: 7-deazaguanines in DNA: mechanism and structure of complex genome modification

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Down Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: Boulder

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE Down syndrome (DS) pre-disposes individuals for early-age onset Alzheimer’s disease (AD), and sleep disturbances are common sequelae in both pathologies. This relationship suggests that chronic sleep disturbance in DS could be one factor that contributes to or hastens the onset of AD. The purpose of this grant is to determine the extent that trisomy21 candidate mediators, Amyloid Precursor Protein (APP) and Regulator of calcineurin1 (RCAN1), contribute to sleep disturbances in DS, thus establishing a mechanistic link between DS and early-age onset AD.

PI_NAMEs: HOEFFER, CHARLES A (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: Address;Affect;Age;Age of Onset;age related;aged;Aging;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease risk;Amyloid Beta A4 Precursor Protein;Amyloid beta-42;Amyloid beta-Protein;Amyloid beta-Protein Precursor;ARNTL gene;Articulation;awake;Basic Science;Behavior;Behavior assessment;Biochemical;Biological Assay;Brain;Calcineurin;calcineurin phosphatase;Cell model;Chromosome 21;Chronic;circadian;Circadian Dysregulation;circadian pacemaker;Clinical;Cognition;Cognitive;Cognitive deficits;cytokine;Data;Defect;Development;Disease;Disease Progression;Dose;Down's Syndrome;early onset;Early Onset Alzheimer Disease;Electroencephalography;Electrophysiology (science);Evaluation;experimental study;gene correction;Gene Dosage;Gene Expression;Gene Expression Profile;Genes;genetic manipulation;glial activation;Goals;Grant;Health;high reward;high risk;Hippocampus;Human;immune activation;Impaired cognition;Impairment;improvement on sleep;Individual;Induced pluripotent stem cell derived neurons;innovation;insight;Knowledge;Link;Measurement;Measures;Mediator;Methods;Mission;Mitochondria;Modeling;Molecular;mouse model;mouse Ts65Dn;multi-electrode arrays;Mus;Nerve Degeneration;neural;Neurobiology;neuroinflammation;Neurologic Deficit;Neurons;neuropathology;non rapid eye movement;Outcome;Outcome Measure;overexpression;Pathologic;Pathology;Phenotype;Process;Property;Protein Isoforms;Protein Overexpression;Proteins;Publishing;Quality of life;Research;restoration;Role;Sleep;sleep abnormalities;Sleep Apnea Syndromes;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep quality;Slice;Synapses;Synaptic plasticity;Synaptic Transmission;tau Proteins;Testing;theories;Therapeutic;Time;transcriptome;Trisomy;United States National Institutes of Health;Work

PROJECT_TITLE: Sleep abnormalities in Down Syndrome-related Alzheimer's disease

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Clinical Research;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: San Francisco

ORG_NAME: VIVID VISION, INC.

PHR: Project narrative Over 3 million Americans have glaucoma, of whom 120,000 are blind. Visual field tests are essential for monitoring the treatment of glaucoma to prevent vision loss. We made a new test with a modernized task, called Vivid Vision Perimetry (VVP) that patients can easily use on their own at home to collect massive amounts of data about their vision. In the proposed project, we will quantify the ability of VVP to detect loss of vision in patients with glaucoma, so patients can know within months rather than years whether they can stop worrying, or need to take additional action to save their vision.

PI_NAMEs: BACKUS, BENJAMIN T (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: 7 year old;aggressive therapy;Agreement;Algorithms;American;Binocular Vision;blind;Blindness;Clinic;Clinical;clinical efficacy;Clinical Trials;Cognitive;cognitive ability;Computer software;cost;Data;Data Collection;data exchange;Data Set;design;Devices;Diagnosis;Diagnostic;Disease Progression;effective therapy;Elderly;Equipment;Eye;Eye Movements;Fatigue;FDA Emergency Use Authorization;Feedback;field study;Frequencies;Glaucoma;Health Insurance Portability and Accountability Act;Home;home test;improved;Insurance;Location;Marketing;mathematical model;Measurement;Measures;Medical;medical schools;Medicare;Methods;Modeling;Modernization;Monitor;Names;novel;Outcome;Patient Education;Patients;Pattern;Perimetry;Persons;Phase;Physicians;Play;Preparation;prevent;Procedures;Psychophysics;rapid detection;Sales;sample fixation;Sampling;San Francisco;Screening procedure;Severities;Site;skills;Small Business Innovation Research Grant;Software Engineering;Source;Specialist;standard of care;Stimulus;Structure;System;Telemedicine;Test Result;Testing;Therapeutic;Time;tool;Training;usability;user-friendly;Video Games;virtual reality game;virtual reality headset;Vision;Visual Fields

PROJECT_TITLE: Clustered home assessment of visual fields in patients with glaucoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-M(12)B]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: BERKELEY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE High utilizers of the emergency department have a very heavy burden of chronic illness, significant unmet social and behavioral health needs, and account for a large proportion of health care spending. Improving care and decreasing costs of this patient population is an urgent demand for health systems. This project will provide evidence about the effectiveness of patient navigation for emergency department high utilizers, and will result in an evidence-based, optimized model of patient navigation to disseminate and test in future research.

PI_NAMEs: FLEMING, MARK  (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: The Effectiveness of Patient Navigation to Address Social and Behavioral Health Needs for Emergency Department High Utilizers.

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Current approaches to the measurement of shared decision making (SDM), a process in which patients and clinicians work together to understand the patient’s problematic situation and collaboratively develop a plan of care, are inadequate in determining if SDM occurs when a patient and clinician make a decision together. Therefore, the objectives of this proposal are to develop a theoretically based, expert-informed, user-tested, observer-based measure of if SDM occurs (“SDMo”), and to estimate its reliability and validity. The outcome of this work, led by a team of experts in SDM, measure development and validation, and user-centered design, will enable a more accurate assessment of how often SDM is used in the care of patients with multiple chronic health conditions and, in the longer term, improve the quality and consistency of research on SDM in this priority population.

PI_NAMEs: HARGRAVES, IAN  (contact)

PROGRAM_OFFICER_NAME: ZHANG, XINZHI

PROJECT_TITLE: SDMo – a measure of the occurrence of SDM in the care of patients with chronic conditions

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


NIH_SPENDING_CATS: Biotechnology;Immunization

ORG_NAME: PARTILLION BIOSCIENCE CORPORATION

PHR: NARRATIVE Monoclonal antibody therapies are an important class of therapies that have been used to treat a wide range of diseases including cancer, autoimmune conditions, and even viral infections like COVID-19. We propose to develop easily accessible tools so that scientists can more quickly discover the best antibodies, and understand their function at the earliest stages of discovery. Enabling more access to cutting-edge tools ultimately will yield cost savings to health systems and better outcomes for more patients.

PI_NAMEs: DE RUTTE, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Adoption;Affinity;Agonist;antagonist;Antibodies;Antibody Diversity;Antibody Repertoire;Antigen Targeting;Antigens;Autoimmune Diseases;B-Cell Antigen Receptor;Bacteriophages;Benchmarking;Binding;Binding Proteins;Biological Assay;Biotechnology;Capital;Cell Line;Cell membrane;Cell Separation;Cell surface;Cells;Cellular Assay;Chromium;commercialization;cost;Cost Savings;COVID-19;Crowding;Data;Democracy;Development;Disease;drug discovery;Equipment;Expenditure;fluorescence activated cell sorter device;Genomics;Health system;high throughput screening;Hybridomas;Hydrogels;Immunization;Immunoglobulin-Secreting Cells;Immunologics;improved;Incubated;instrument;Interview;Label;laboratory equipment;Laboratory Research;Light;Link;Malignant Neoplasms;Marketing;Membrane;Methodology;Microfluidics;Modality;Modeling;Monoclonal Antibody Therapy;MS4A1 gene;Outcome;particle;Patients;Performance;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Plasma Cells;Process;Property;Rare Diseases;Reagent;receptor;Receptor Signaling;Reporter;Research;Running;Scientist;screening;Side;Signal Pathway;Signal Transduction;single cell sequencing;Small Business Innovation Research Grant;Sorting;Surface Antigens;System;Technology;Testing;Therapeutic;therapeutic candidate;therapeutic development;therapeutic target;Tissues;TNFRSF1A gene;tool;Training;Tube;Virus Diseases;Work;Yeasts

PROJECT_TITLE: Linking antibody sequences to function at the single-cell level using nanovial technology


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Burden of Illness;Cancer;Clinical Research;Health Services;Patient Safety;Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: UROLOGY

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE New, molecular imaging tests offering improved detection of prostate cancer are changing the management of the disease in ways that are not understood but have the potential for both positive and negative effects on patients and their disease. In this proposal we aim to understand the effectiveness of molecular imaging tests with the goal of helping patients and prostate cancer stakeholders make more informed clinical decisions that account for the cascade of effects that can be set into motion. To accomplish this, we will generate new evidence relating to the effects of PET imaging in the real-world setting, ultimately integrating this data in a decision model that will generate a clearer picture about the tradeoffs of imaging, including practical scenarios that are most or least likely to benefit patients.

PI_NAMEs: LEAPMAN, MICHAEL STUART (contact)

PROGRAM_OFFICER_NAME: KOBRIN, SARAH

PROJECT_TERMS: Accounting;Affect;Aftercare;Age;androgen deprivation therapy;androgen independent prostate cancer;Anxiety;Benefits and Risks;Biological;bone imaging;cancer care;Cancer Etiology;cancer site;cancer type;Cessation of life;Characteristics;Clinical;clinical care;Clinical effectiveness;clinical efficacy;Clinical Management;clinical risk;Complex;cost;cost effectiveness;Data;data integration;Databases;Decision Making;Decision Modeling;Diagnostic;diagnostic accuracy;Diagnostic Neoplasm Staging;Dimensions;Disease;Disease Management;Disease Outcome;Disease Progression;Disseminated Malignant Neoplasm;Early Diagnosis;Effectiveness;effectiveness evaluation;Electronic Health Record;Evaluation;experience;Funding;Goals;Harm Reduction;Health Care Costs;health related quality of life;holistic approach;Hormones;Image;imaging agent;imaging modality;improved;Individual;innovation;insight;Institution;Interview;Knowledge;Lead;Life Expectancy;Long-Term Effects;Malignant neoplasm of prostate;Measures;men;Modeling;models and simulation;molecular imaging;Motion;Outcome;Outcome Measure;Output;Pathway interactions;Patient Outcomes Assessments;Patient Preferences;patient subsets;Patients;Performance;Physicians;Positron-Emission Tomography;preference;Provider;PSA level;psychologic;Radiation;reduce symptoms;Refractory Disease;Risk;Risk Assessment;Role;Screening for Prostate Cancer;Source;Staging;Surrogate Endpoint;Systemic Therapy;Test Result;Testing;Time;Tracer;treatment duration;Treatment-related toxicity;Uncertainty;United States;United States Food and Drug Administration;Vacuum;Work;X-Ray Computed Tomography

PROJECT_TITLE: Optimizing prostate cancer care:  integrating risks, benefits, and patient experiences in the new era of molecular imaging

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Osteogenesis Imperfecta;Pediatric;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative This project serves to train an MD-PhD student in translational research in rare bone diseases, specifically Osteogenesis Imperfecta (OI). I will investigate the therapeutic potential of the Wnt/Frizzled2 pathway for the treatment of skeletal and extraskeletal manifestations of OI.

PI_NAMEs: ADEYEYE, MARY IFEOLUWA (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Aftercare;Age Months;Anabolism;Antibodies;beta catenin;Binding;biomechanical test;Biomechanics;Birth;bisphosphonate;bone;Bone Diseases;bone fragility;bone loss;bone mass;Bone Matrix;Bone structure;bone turnover;career;Cell Nucleus;Cell Physiology;Cell Proliferation;Cerebellar Diseases;Circulation;Clinical;Clinical Research;COL1A1 gene;COL1A2 gene;Collagen;Collagen Type I;Complex;Connective Tissue Diseases;crosslink;Defect;Deformity;design;Disease;doctoral student;dominant genetic mutation;Dose;early onset;Family;FDA approved;Female;Fracture;fracture risk;FRAP1 gene;Future;gain of function;Gene Proteins;Genes;Genetic Transcription;Homeostasis;Human;improved;In Vitro;in vivo;Incidence;inhibitor;insight;International;Investigation;Japanese;Lead;loss of function;male;Mediating;Medical;Meta-Analysis;Minerals;Modeling;Molecular;Molecular Analysis;Monomeric GTP-Binding Proteins;mouse model;Mus;neurodevelopment;novel;Operative Surgical Procedures;osteoblast differentiation;Osteoblasts;Osteocytes;Osteogenesis;Osteogenesis Imperfecta;Osteoporosis;overexpression;Pathogenicity;Pathological fracture;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Phosphorylation;Physicians;Physiologic calcification;Play;Population;Post-Translational Protein Processing;Pre-Clinical Model;Prevalence;prevent;Process;Procollagen;rare mendelian disorder;receptor;Recurrence;rho;Role;Scientist;Serum;Signal Pathway;Signal Transduction;Signaling Molecule;Sirolimus;skeletal;Stromal Cells;System;Testing;Therapeutic;therapeutic candidate;Therapeutic Uses;therapeutically effective;tibia;trafficking;Training;transcriptomics;Translational Research;treatment group;Variant;Wild Type Mouse;Wnt proteins;WNT Signaling Pathway;WNT1 gene;Work;Zoledronate

PROJECT_TITLE: Mechanistic investigation into Frizzled-2 signaling for treatment of Osteogenesis Imperfecta


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Johnson, Kevin DP1 Details Project Name: Helping Doctors Doctor: Using AI to Automate Documentation and “De-Autonomate” Health Care Project Narrative Clinical encounter documentation has become an increasingly burdensome, typically manual process that has been implicated as a major source of physician cognitive burden and job dissatisfaction. At the same time, computer science methods such as natural language processing and deep learning have yet to be explored as alternative approaches to summarizing medical data collected in real time. As a pediatrician and biomedical informatician with considerable expertise in real-world systems design, I propose to use those skills to design and test methods to automate documentation from clinical encounter audio, video, and EHR data and to demonstrate its feasibility as a novel documentation approach that improves the quality of what is communicated.

PI_NAMEs: JOHNSON, KEVIN B. (contact)

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: Algorithms;Area;burnout;Characteristics;Clinical;clinical encounter;cognitive load;Communication;computer science;computer scientist;Computer Vision Systems;Consumption;cost;Country;Data;Data Analytics;data streams;Decision Making;deep learning;design;Diagnosis;Documentation;Electronic Health Record;Engineering;Generations;Genetic Transcription;Goals;Healthcare;Hour;Image;implicit bias;improved;Investigation;Label;Learning;learning strategy;Length;Machine Learning;Manuals;Medical;Methods;multidisciplinary;Names;Natural Language Processing;novel;Occupations;Patients;Pattern;pediatrician;Physicians;Process;Quality of Care;skills;Source;supervised learning;System;Techniques;Technology;Testing;Time;unsupervised learning;User-Computer Interface;Work

PROJECT_TITLE: Helping Doctors Doctor: Using AI to Automate Documentation and "De-Autonomate" Health Care


ORG_DEPT: NEUROLOGY

PHR: NARRATIVE The NIH has created the Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to the national opioid public health crisis. Trials will be conducted through the NIH HEAL Pain Management Effectiveness Research Network (HEAL Pain ERN), which will use the infrastructure of the NCATS Trial Innovation Network to provide scientific guidance and coordination of the HEAL Pain ERN Trials. The four innovation centers (3 TICs, 1 RIC) will provide integrated functions for the clinical coordinating resource center, data coordinating resource center, statistics and safety resource center, and recruitment resource center. The Johns Hopkins-Tufts TIC will serve as the statistics and safety resource center.

PI_NAMEs: HANLEY, DANIEL F (contact)

PROGRAM_OFFICER_NAME: VALLEJO, YOLANDA F

PROJECT_TERMS: Administrator;Area;Award;Clinical;Clinical Trials;Collaborations;Data;Data Coordinating Center;design;effectiveness research;experience;Helping to End Addiction Long-term;Infrastructure;innovation;Joints;Lead;Leadership;Multi-Institutional Clinical Trial;multi-site trial;National Center for Advancing Translational Sciences;Opioid;Pain;Pain management;programs;Protocols documentation;Public Health;recruit;Research;Resources;Safety;Scientist;Sickle Cell;Specific qualifier value;Speed;statistics;United States National Institutes of Health;Universities;Utah;Work

PROJECT_TITLE: Johns Hopkins Statistical and Safety Resource Center-HEAL PAIN ERN


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Screening and Brief Intervention for Substance Misuse;Sleep Research;Social Determinants of Health;Substance Misuse

ORG_CITY: Los Angeles

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE The scientific goal of this project is to examine the efficacy of a mobile insomnia app, enhanced with brief alcohol intervention content, for non-treatment involved post-9/11 veterans with insomnia disorder and alcohol use disorder (AUD). Results of this study will have public health impact by assessing the evidence of a mobile intervention for an at-risk sample of veterans in need of treatment. Further, this intervention has great potential for widespread dissemination for both veterans and civilians presenting with insomnia and AUD symptomology.

PI_NAMEs: KUHN, ERIC ROLAND;PEDERSEN, ERIC R. (contact)

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: Address;Affect;Aftercare;alcohol consequences;Alcohol consumption;alcohol misuse;alcohol use disorder;Alcohols;American;barrier to care;Behavior;Behavioral;behavioral health;brief alcohol intervention;care seeking;Caring;Cognitive Therapy;comparison control;Data;Disease;drinking;drinking behavior;dual diagnosis;efficacy evaluation;efficacy testing;ethnic minority;Ethnic Origin;evidence base;Exclusion;Exclusion Criteria;follow-up;Frequencies;Goals;health communication;Health Services Accessibility;Healthcare;Healthcare Systems;Heavy Drinking;high risk;improved;improvement on sleep;Individual;interest;Intervention;intervention delivery;intervention effect;Interview;Learning;Link;marijuana use disorder;Mediating;meetings;Mental Depression;Mental Health;Military Personnel;military veteran;mobile application;mobile computing;Motivation;normative feedback;novel;Occupational;Outcome;Participant;Persons;Phase;physical conditioning;Population;post 9/11;Post-Traumatic Stress Disorders;preference;Prevalence;Prevention strategy;primary outcome;Public Health;Race;racial minority;Randomized, Controlled Trials;recruit;relapse prevention;Reporting;Research;Risk;Sampling;Schedule;secondary outcome;Self Direction;sex;Sleep;Sleep Disorders;sleep health;sleep quality;Sleeplessness;social media;social stigma;standard care;Stigmatization;substance use;Surveys;Symptoms;Technology;telehealth;Testing;Transportation;treatment as usual;Treatment outcome;Underserved Population;usability;Veterans;Veterans Health Administration;willingness;Woman;Work

PROJECT_TITLE: A Mobile App to Address Co-Occurring Sleep Problems and Heavy Alcohol Use among Veterans Outside of Care Settings

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Methamphetamine;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

PHR: Psychomotor stimulant drugs such as methamphetamine and the cathinone derivatives known as “bathsalts” are highly addictive. This project will investigate the factors that contribute to escalating stimulant drug intake using a rat model of intravenous self-administration. In total, these studies will advance our understanding of how dependence on psychomotor stimulant drugs develops and is maintained.

PI_NAMEs: TAFFE, MICHAEL A. (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Abstinence;abuse liability;Acute;addiction;Address;Admission activity;Adult;African American population;Alcohols;Amphetamines;analog;Animal Model;Annual Reports;Attention;bath salts;Behavior;Behavioral;Bite;Brain;cathinone;caucasian American;Cessation of life;Clinical Laboratory Information Systems;Cocaine;Consumption;cost;Data;Death Rate;Dependence;Development;diagnostic criteria;Exhibits;experience;experimental study;Forensic Medicine;Goals;Health;Human;Imprisonment;indexing;Individual;Intake;Intervention;Intravenous;Investigation;Law Enforcement;Maintenance;Methamphetamine;methamphetamine use;Methamphetamine use disorder;methamphetamine user;Modeling;Native Americans;Negative Reinforcements;Not Hispanic or Latino;novel;Opioid;Oxycodone;Pattern;Personal Satisfaction;Pharmaceutical Preparations;Phenotype;Population;preclinical study;prevent;psychostimulant;Psychotropic Drugs;Rattus;reinforcer;Reporting;Rewards;Role;Self Administration;Self Stimulation;small molecule;socioeconomics;Stimulant;stimulant abuse;stimulant dependence;stimulant use;stimulant use disorder;stimulant user;substance use treatment;Testing;trafficking;United States;United States Substance Abuse and Mental Health Services Administration;Update;Vaccine Therapy;Waxes

PROJECT_TITLE: Dissecting the Abuse Liability of  Cathinone and Amphetamine Stimulants

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Hematology;Lung;Patient Safety

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Submassive pulmonary embolism (PE) is a common dangerous disease that often causes cardiopulmonary disability, reduced functional capacity, and decreased quality of life; catheter-directed therapy (CDT), by acutely reducing clot burden and improving right ventricular function, has the potential to prevent these long- term complications. This study will determine if CDT, rather than anticoagulant therapy alone, should be used to treat patients with submassive PE. The Data Coordinating Center, led by experts with deep experience in adaptive and pragmatic clinical trial design and implementation, will oversee all aspects of study design, implementation, and analysis, and will provide state-of-the-art data collection and quality control infrastructure, reporting to the independent Data and Safety Monitoring Board, and provision of data and resources to the public.

PI_NAMEs: TARPEY, THADDEUS ;TROXEL, ANDREA B (contact)

PROGRAM_OFFICER_NAME: NEIDERT, LESLIE EAVES

PROJECT_TERMS: Activities of Daily Living;Acute;adjudication;adverse event monitoring;Anticoagulant therapy;Anticoagulation;Benefits and Risks;Berry;Biometry;Blinded;Blood Pressure;Budgets;Cardiopulmonary;Catheters;Cessation of life;Clinical;clinical center;clinical practice;Clinical Trials;Clinical Trials Data Monitoring Committees;Clinical Trials Design;Coagulation Process;Consultations;cost;cost comparison;Cost Effectiveness Analysis;cost per quality-adjusted life year;Dangerousness;Data;Data Analyses;Data Collection;Data Coordinating Center;data de-identification;data integrity;data quality;data repository;Data Set;Databases;design;Deterioration;disability;Disease;Dose;Economics;effectiveness study;efficacy outcomes;Enrollment;Ensure;Event;Excision;exercise capacity;Exercise Test;experience;feasibility trial;Fibrinolytic Agents;follow-up;functional status;Futility;Gatekeeping;Goals;Health;Heart;Hemorrhage;improved;incremental cost-effectiveness;Infrastructure;innovation;Measures;Methodology;Mission;National Heart, Lung, and Blood Institute;New York;open label;Outcome;Outcome Study;Oxygen Consumption;Patients;Phase;Pragmatic clinical trial;prevent;Procedures;Process;Protocol Compliance;Public Health;Publications;Pulmonary artery structure;Pulmonary Embolism;Quality Control;Quality of life;Randomized;randomized trial;Randomized, Controlled Trials;Recurrence;Reporting;Research Design;Resources;Right Ventricular Dysfunction;Right Ventricular Function;Risk;safety outcomes;Sample Size;screening;Security;Standardization;Statistical Data Interpretation;Testing;thrombolysis;Thrombolytic Therapy;Thrombus;Time;treatment group;trial design;venous thromboembolism;Walking;Work;Writing

PROJECT_TITLE: 2/2 Pulmonary Embolism: Thrombus Removal with Catheter-Directed Therapy (PE-TRACT Trial) –DCC

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(JA)]