ORG_CITY: CLEVELAND

ORG_DEPT: BIOLOGY

ORG_NAME: CUYAHOGA COMMUNITY COLLEGE

PHR: Project Narrative The relevance of the Bridges to the Baccalaureate Research Training Program at Cuyahoga Community College is that it increases the number of underrepresented minority students who study in biomedical and behavioral science disciplines. Bridges students advance through the academic pipeline into graduate and postgraduate study and join the scientific research community.

PI_NAMEs: GATICA, JORGE E;HATZOGLOU, MARIA ;VARHEGYI, GEZA GABOR (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Academic support;Bachelor's Degree;Behavioral Sciences;bridge program;bridge to the baccalaureate;cohort;college;community college;design;Educational workshop;experience;faculty mentor;Financial Support;Goals;Grant;Hour;Institution;Laboratories;meetings;Mentors;Modeling;Monitor;operation;Pathway interactions;programs;Research;Research Methodology;Research Training;Scholarship;Science;science education;Series;student participation;student training;Students;success;summer research;Techniques;Training Programs;undergraduate research experience;Underrepresented Minority;underrepresented minority student;Underrepresented Students;United States National Institutes of Health;Universities;Work

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Neurosciences;Physical Activity;Prevention

ORG_CITY: LA JOLLA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: NARRATIVE  While physical activity has many health benefits, people with HIV are often not able to reap these benefits due to physical limitations that prevent them from participating in physical activity. This project aims to develop data supporting the use of GPLD1 to improve markers of health status and cognition in people with HIV.

PI_NAMEs: ELLIS, RONALD J. (contact);HENRY, BROOK

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Accelerometer;actigraphy;Adherence;Adult;Aging;Animal Model;Animals;Anti-Retroviral Agents;antiretroviral therapy;Behavioral;Biogenesis;Biological Markers;Blood specimen;Blood Vessels;Brain;brain tissue;Cell Surface Proteins;Cessation of life;Clinical;Clinical Data;Clinical Trials;Coagulation Process;Cognition;Cognitive;cognitive benefits;cognitive function;cohort;cost;Data;Dependence;design;Dose;Elderly;Encephalitis;Enzymes;Evaluation;Exercise;exercise intervention;Exhibits;Fatigue;fitbit;Funding;Future;Genes;Glycosylphosphatidylinositols;GPI Membrane Anchors;Growth;Health;Health Benefit;Health Status;Hepatotoxicity;Hippocampus;HIV;Human;Impaired cognition;Impairment;improved;indexing;Inflammation;inflammatory marker;inhibitor;Injections;Injury;innovation;Intervention;Learning;Light;Liver;Measures;Mediating;Medical;meetings;member;Memory;Memory impairment;Mitochondria;Moderate Exercise;Monitor;Moods;mouse model;Mus;neural;Neurocognitive;Neurocognitive Deficit;neurogenesis;Neurons;Neuropathy;neurotoxicity;novel;old mice;Outcome;painful neuropathy;Paper;Pathway interactions;Performance;Persons;Phase I Clinical Trials;Phosphatidic Acid;Phospholipase D;phospholipase D1;Physical activity;PI-Glycan;Plasma;Polysaccharides;Population;pre-clinical;prevent;Process;Proteins;Publishing;Pulmonary Heart Disease;Quality of life;recruit;remediation;Reporting;response;Role;Sampling;Science;Serum;Services;sex;Short-Term Memory;Socioeconomic Factors;Strenuous Exercise;Testing;Vascular remodeling;Viral;Visit;Work

PROJECT_TITLE: GPLD1: Association with Cognition and Amelioration through Exercise in Aging People with HIV

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative One quarter of the world’s population carries the burden of tuberculosis. Efforts to reduce this burden have been hindered by the lack effective diagnostics and a protective vaccine underpinned by gaps in the understanding of the immune response in tuberculosis disease. The proposed research will examine the role of humoral immunity in tuberculosis disease with the vision that antibody features may be harnessed to expand the repertoire for immune correlates, diagnostics and rational vaccine design.

PI_NAMEs: LU, LENETTE  (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Acceleration;adaptive immune response;Address;Aerobic;Antibodies;Antibody Diversity;antibody-dependent cell cytotoxicity;Antigens;antimicrobial;Bacteria;Bacterial Infections;Binding;Biological Assay;Capillary Electrophoresis;CD4 Positive T Lymphocytes;Cell Physiology;Cells;Cellular Immunity;Cessation of life;Chemicals;Chronic;chronic infection;clinically significant;Communicable Diseases;Data;Diagnostic;Disease;disease heterogeneity;Disease Progression;Environment;Enzymes;Exhibits;Fab domain;Fc domain;Fc Receptor;Flow Cytometry;glycosylation;Goals;Growth;Human;Humoral Immunities;Hypoxia;Immune;Immune response;Immunity;Immunoglobulin G;Immunology;In Vitro;in vitro Model;in vivo;in vivo Model;Individual;Infection;Inflammasome;inhibitor;latent infection;Link;Lysosomes;Macrophage;Measures;Microbe;Modeling;Molecular;monocyte;mouse model;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;Outcome;Pathway interactions;Pattern;permissiveness;Persons;Phagocytosis;Physiological;Population;pressure;prevent;Property;Publishing;receptor;recruit;Research;response;Risk;Role;Serodiagnoses;Signal Pathway;Signal Transduction;small hairpin RNA;T-Lymphocyte;Testing;Therapeutic;Tuberculosis;tuberculosis immunity;Vaccine Design;vaccine development;Vaccines;Viral Antibodies;Vision;Work

PROJECT_TITLE: Defining the antibody interface between Mycobacterium tuberculosis and host immunity

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: NARRATIVE – Overall The UCLA Brain Cancer SPORE will support research into new and innovative strategies to diagnose and treat brain cancer, particularly focusing on innovative ways to overcome the problem of treatment-induced resistance to current therapies (i.e., immunotherapy, chemo/drug therapy, and radiation therapy resistance). Despite many different treatment approaches, the five-year survival rate for glioblastoma (WHO grade IV) patients remains dismal, and there are still no definitive cures for this disease. Thus, the proposed research is of relevance to public health, as there is clearly an unmet need for patients with this type of cancer and continued investigations into novel therapeutic approaches for brain cancer are desperately needed.

PI_NAMEs: LIAU, LINDA M (contact)

PROGRAM_OFFICER_NAME: HUBBARD, LEAH

PROJECT_TERMS: Active Immunotherapy;Acute;Address;anti-cancer research;Apoptosis;Apoptotic;Area;Awareness;Basic Science;Biochemistry;Bioinformatics;Biological Markers;Biomedical Engineering;Biometry;Brain;Brain Neoplasms;Cancer Patient;cancer type;career;career development;Cell Death;Cell Nucleus;Cells;Clinical;clinical care;Clinical Research;Combined Modality Therapy;Companions;CSF1R gene;data management;design;Development;Diagnosis;Discipline;Disease;Endocrinology;Equilibrium;Fostering;Funding;Future;Glioblastoma;Glioma;Goals;Grant;Head and Neck Surgery;Human;human capital;Human Genetics;Image;Immune Evasion;Immunology;Immunotherapeutic agent;Immunotherapy;improved;Industry;Infrastructure;innovation;Institution;International;Investigation;Laboratories;Leadership;Magnetic Resonance Imaging;Malignant neoplasm of brain;Medicine;Metabolism;Microbiology;Molecular Genetics;multidisciplinary;neoplastic cell;neuroimaging;Neurosciences;new technology;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Paper;Pathology;Patients;Pediatrics;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Phenotype;Physicians;Positron-Emission Tomography;pre-clinical;Prognosis;programmed cell death protein 1;programs;Psychiatry;Public Health;Publishing;Radiation;Radiation Oncology;Radiation therapy;Radiology Specialty;Reproduction spores;Research;Research Personnel;Research Project Grants;Research Support;Resistance;Resource Sharing;Scientist;Specimen;stem cells;Survival Rate;Talents;Technology;Testing;therapy development;therapy resistant;translational approach;Translational Research;translational research program;tumor diagnosis;tumor microenvironment;United States National Institutes of Health;Vaccination;Work

PROJECT_TITLE: UCLA SPORE in Brain Cancer


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Rare Diseases

PROJECT_TERMS: Acceleration;Advocate;Animals;Brain;Brain Neoplasms;Budgets;Cancer Center;Cancer Patient;career;Clinical;clinical application;Collaborations;Committee Members;Communication;Comprehensive Cancer Center;Contracts;daily functioning;Data;data management;Dedications;Development;Diagnosis;Doctor of Philosophy;Educational workshop;Ensure;Evaluation;Goals;Grant;Human;human subject;improved;Industry;Information Dissemination;innovation;Institution;Intranet;Leadership;Maintenance;Malignant neoplasm of brain;meetings;member;Minority;Minority Recruitment;Monitor;Occupational activity of managing finances;Organ;patient advocacy group;Patients;Policies;Principal Investigator;Prognosis;programs;Progress Reports;Publications;Records;Regulation;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Schedule;Science;Site;symposium;Translational Research;Underrepresented Minority;United States National Institutes of Health;Update;web site;webinar;Woman

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunization;Immunotherapy;Neurosciences;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

PHR: PROJECT NARRATIVE – Project 1 The studies proposed herein are designed to investigate mechanisms of immune evasion following active immunotherapy with brain cancer vaccines. We will test our hypothesis that clinically relevant anti-tumor immunity to glioblastoma (GBM) must have two cellular components: 1) significant infiltration of tumor-specific tumor-infiltrating lymphocytes (TIL); and 2) blockade of immunosuppressive tumor infiltrating myeloid cell (TIM) function within the tumor microenvironment. We believe that a combination of active vaccination (ATL-DC; to induce T-cell infiltration into tumors), immune checkpoint inhibition (to enhance T cell function), and CSF-1R inhibition (to block suppressive TIM function) may lead to improved outcomes for the treatment of glioblastoma.

PI_NAMEs: PRINS, ROBERT M (contact)

PROJECT_TERMS: Active Immunization;Active Immunotherapy;Animal Model;Animals;anti-PD-1;anti-tumor immune response;Ants;Attenuated;Autologous;Blood;Brain;Brain Neoplasms;Cancer Vaccines;CD8B1 gene;Cell Physiology;Cells;Cellular biology;checkpoint inhibition;Chronic;Clinical;Clinical Trials;clinically relevant;CSF1R gene;Data;dendritic cell vaccination;Dendritic Cell Vaccine;Dendritic Cells;design;Development;effective therapy;first-in-human;Funding;Gene Expression;Genes;Glioblastoma;Glioma;Health;imaging biomarker;imaging modality;Imaging technology;Immigration;Immune;immune checkpoint blockade;Immune Evasion;immune resistance;Immune response;immunogenicity;Immunologic Markers;Immunologic Monitoring;ImmunoPET;Immunotherapy;improved outcome;Infiltration;inflammatory milieu;inhibitor;innovation;insight;Magnetic Resonance Imaging;Malignant neoplasm of brain;Mediating;Modeling;Monoclonal Antibodies;mouse model;Mus;Myeloid Cells;Myeloid-derived suppressor cells;Neoadjuvant Therapy;neoplasm immunotherapy;neoplastic cell;Newly Diagnosed;novel;Patients;PD-1 blockade;pembrolizumab;Phase I Clinical Trials;Phenotype;Physiologic pulse;Positron-Emission Tomography;pre-clinical;preclinical study;programmed cell death protein 1;Recurrence;Resistance;resistance mechanism;response;response biomarker;Series;T cell infiltration;T cell response;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Toxic effect;Translational Research;Treatment outcome;tumor;Tumor Immunity;tumor microenvironment;Tumor-infiltrating immune cells;Tumor-Infiltrating Lymphocytes;Vaccination;vaccination strategy;Vaccines;Virus Diseases

PROJECT_TITLE: Project 1:  Targeting immunotherapy-induced resistance with DC vaccination and PD-1/CSF-1R inhibition


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative This proposal aims to support the training of the diverse next generation of researchers who will make fundamental discoveries related to the neuroscience underlying normal communication, effects of hearing loss and dysfunction of communicative abilities. They will work toward applying those discoveries and developing them into safe and effective therapies for affected individuals. As a long- term research-training program, this effort will reap the rewards of its investments over decades of research advancements achieved through the careers of the trainees.

PI_NAMEs: LEE, ADRIAN KC;PERKEL, DAVID J (contact);SHEN, YI

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TITLE: Auditory Neuroscience Training Program


NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Orphan Drug;Rare Diseases

PHR: PROJECT NARRATIVE – Project 2 The studies proposed herein aim to target resistance to intrinsic apoptosis for increased glioblastoma tumor lethality. The integration of molecular and functional diagnostics, including BH3 profiling and non-invasive PET and MR imaging, will aid in the translation of new therapeutic agents designed to exploit the intrinsic apoptotic machinery.

PI_NAMEs: NATHANSON, DAVID A. (contact)

PROJECT_TERMS: Ablation;antagonist;antitumor effect;Apoptosis;Apoptotic;Automobile Driving;BCL1 Oncogene;BCL2 gene;BCL2L1 gene;Brain;cancer type;Cell Death;Cell Membrane Permeability;Cessation of life;chemotherapy;Clinical;clinical effect;Clinical Research;Clinical Trials;Collaborations;Data;Dependence;design;Diagnostic;DNA Damage;drug candidate;Drug resistance;effective therapy;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Excision;exome;exome sequencing;Family member;fluorodeoxyglucose positron emission tomography;Funding;Genotype;Glioblastoma;Glioma;Human;improved;in vivo;Investigation;Lead;Libraries;Magnetic Resonance Imaging;Malignant Glioma;Malignant neoplasm of brain;Malignant Neoplasms;MCL1 gene;Mediating;metabolic imaging;Mitochondria;Modeling;Molecular;molecular targeted therapies;mouse model;mutant;neoplastic cell;novel;novel therapeutics;Oncogenic;Outer Mitochondrial Membrane;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Positron-Emission Tomography;pre-clinical;preclinical study;predictive marker;prevent;Protein Family;Radiation;Recurrence;Refractory;Resistance;resistance mechanism;response;response biomarker;Sampling;Specificity;Specimen;targeted treatment;temozolomide;Testing;Therapeutic;Therapeutic Agents;therapeutic target;Therapeutic Uses;TP53 gene;transcriptome sequencing;Translations;tumor

PROJECT_TITLE: Project 2:  Overcoming drug-induced resistance to intrinsic apoptosis in glioblastoma


ED_INST_TYPE: HOSPITALS

ORG_CITY: HOUSTON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Project Narrative The ability to distinguish harmful and beneficial microbes is critical for the survival of animals, including humans. Our study suggests that bloating of the intestine caused by colonization of pathogenic bacteria may be a general mechanism involved in the recognition of a broad range of microbes and that it modulates host immune response and behavior via neuroendocrine signaling. Overall, a better understanding of the recognition of physiological alterations caused by infections and the neural mechanisms of control of inflammation is highly relevant to public health because inflammation accounts for the major physiological, metabolic, and pathological responses to infections.

PI_NAMEs: ABALLAY, ALEJANDRO  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Ablation;Afferent Neurons;Animals;avoidance behavior;Bacterial Infections;Bacterial Toxins;Behavior;Behavioral;beneficial microorganism;C. elegans genome;Caenorhabditis elegans;Cells;Complex;Control Animal;Cues;Dissection;Endocrine;Ensure;Environment;Esthesia;Exhibits;Experimental Designs;experimental study;Exposure to;fighting;formyl peptide;Genes;Genetic;genetic analysis;genetic approach;Genetic Techniques;Homeostasis;Host Defense;Human;Immune;immune activation;Immune response;Immune signaling;Immune system;Infection;Inflammation;Inflammatory;innate immune mechanisms;innate immune pathways;Innate Immune Response;Innate Immune System;insight;Intestines;Laboratories;Ligands;Link;Lipopolysaccharides;Mammals;Metabolic;Microbe;microbial colonization;Molecular;mutant;Names;Natural Immunity;Nature;Nematoda;Nervous System;neural;neural circuit;neuromechanism;Neurons;Neuropeptide Y Receptor;Neuropeptides;Neurosecretory Systems;neurotransmission;Neurotransmitters;Nociceptors;optogenetics;Organism;pathogen;pathogenic bacteria;pathogenic microbe;Pathologic;Pathway interactions;Physiological;Physiology;Play;promoter;Public Health;Publishing;quorum sensing;receptor;Regulation;response;Role;Signal Transduction;Synapses;System;Technology;Tissues;Toxin;Work

PROJECT_TITLE: Mechanism of innate immune activation by intestinal distension

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ADMINISTERING_IC: HS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative The Architecture of High Value Health Care annual conference is the premier venue in the United States to disseminate performance improvement initiatives related to high-value practice on a national scale. Now in its 5th year, the meeting serves as a forum for national experts from across the country to vet value-based performance improvement work and a platform to disseminate care redesign that safely improves providers' ability to diagnose and treat patients. Changing long-standing provider practice patterns has proven challenging, necessitating a large-scale demonstration of accountability to inspire adoption of higher value health care and determine which interventions most effectively influence prescribing and ordering behavior.

PI_NAMEs: PAHWA, AMIT KUMAR (contact)

PROGRAM_OFFICER_NAME: ZHANG, XINZHI

PROJECT_TITLE: The Architecture of High Value Healthcare

STUDY_SECTION: HSVR

STUDY_SECTION_NAME: Healthcare Systems and Values Research[HSVR]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Neurosciences;Rare Diseases

PI_NAMEs: RODRIGUEZ, FAUSTO  (contact)

PROJECT_TERMS: Adherent Culture;Animals;biobank;Bioinformatics;Biological Models;Biology;Biometry;Blood;Brain Neoplasms;career;Cell Culture Techniques;Cells;Cerebrospinal Fluid;Cerebrum;Clinical;Clinical Trials;Clinical/Radiologic;Collaborations;Collection;comparative;Data;data management;Databases;Development;Diagnostic;Ensure;experience;flexibility;genomic tools;Genomics;Germ Lines;Glioblastoma;Glioma;Health Insurance Portability and Accountability Act;Histologic;Histology;Human;Immunohistochemistry;In Situ Hybridization;in vivo;Institutional Review Boards;Invaded;Malignant neoplasm of brain;Microdissection;Modeling;Molecular;Monitor;neoplastic cell;neuroimaging;neuropathology;next generation;novel;novel therapeutic intervention;Organoids;Pathologic;Pathology;Patients;pre-clinical;preclinical study;preservation;Privacy;programs;Protocols documentation;public repository;rare cancer;Reporter;Research;Research Personnel;Research Project Grants;Research Support;Resistance;Resources;Sampling;Services;Specimen;success;synergism;System;Temperature;Therapeutic Studies;therapeutic target;Tissues;Translational Research;treatment response;tumor;Tumor Burden;tumor diagnostic;tumor microenvironment;Tumor Tissue;tumor xenograft;Urine;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Core 1: Biospecimen and Pathology Core (BiPC)


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

PI_NAMEs: ELLINGSON, BENJAMIN M. (contact)

PROJECT_TERMS: Address;Amines;anatomic imaging;Anatomy;Angiogenesis Inhibitors;Antineoplastic Agents;Apoptosis;Archives;BCL2L1 gene;Beds;Biological Markers;Blood Vessels;Blood Volume;Brain;brain tissue;brain tumor imaging;Caliber;Cataloging;CD8B1 gene;Cell Density;Cellularity;Clinic;Clinical;clinical imaging;Clinical Trials;companion animal;Complex;Computer software;Corpus striatum structure;Data;Diffusion;Diffusion Magnetic Resonance Imaging;Dopamine;effective therapy;EGFR inhibition;Environment;Evaluation;experience;ferumoxytol;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;Functional Imaging;Glioblastoma;Glioma;Goals;Growth;Guidelines;Human;Image;imaging approach;Imaging Techniques;Imaging technology;ImmunoPET;Immunotherapy;In Situ;in vivo;indexing;Individual;insight;International;Link;Macrophage;Magnetic Resonance Imaging;Malignant neoplasm of brain;Measurement;Metabolic;metabolic imaging;molecular imaging;neoplastic cell;neuro-oncology;neuroimaging;novel;novel therapeutic intervention;novel therapeutics;Patient imaging;Patients;Perfusion;perfusion imaging;Phenotype;Physiological;Positron-Emission Tomography;pre-clinical;preclinical imaging;presynaptic;Procedures;Process;Prognosis;Protocols documentation;Public Health;Radiation;radiological imaging;Recurrent tumor;Reproduction spores;Research;Research Personnel;Resolution;Resources;response;Secure;Standardization;subventricular zone;T-Lymphocyte;Techniques;Therapeutic;Therapeutic Clinical Trial;tool;Tracer;Translations;treatment response;tumor;Tumor Biology;tumor metabolism;tumor microenvironment;Tumor-associated macrophages;Vascular Permeabilities

PROJECT_TITLE: Core 2: Neuro-Imaging Core (NIC)


ORG_CITY: Aurora

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative When patients and providers use patient decision aids (PDAs) patients report improved knowledge, satisfaction, patient-provider communication, increased involvement in decision making, and reduced decisional conflict and regret. Despite these meaningful patient-centered outcomes, PDAs continue to be underutilized. We propose to use user-centered design methods to build and test a shared decision aid support system that addresses the patient, clinician, and system barriers to PDA use, supports alignment with the “5 rights of clinical decision support”, and supports reusability, interoperability, and scalability.

PI_NAMEs: SCHILLING, LISA M (contact);SOARES, ANDREY

PROGRAM_OFFICER_NAME: TERAN, MARIO

PROJECT_TITLE: An Interoperable, Reusable and Scalable Shared Decision Aid Navigator System: Supporting the 5 Rights of Patient Shared Decision-Making

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


PI_NAMEs: LI, GANG  (contact)

PROJECT_TERMS: analytical method;analytical tool;anti-cancer research;Applications Grants;Area;Basic Science;Bioinformatics;Biometry;Brain;career;Cellular biology;clinical trial analysis;clinical trial protocol;Clinical Trials;Collaborations;Complex;Comprehensive Cancer Center;Computer software;computerized data processing;Consultations;Data;Data Analyses;design;Development;Developmental Biology;Education;Environment;Evaluation;exome;experience;Experimental Designs;Faculty;Flow Cytometry;Fostering;Funding;gang;Gene Expression;genome sequencing;genomic data;Genomics;Goals;high dimensionality;high throughput technology;Individual;innovation;Leadership;Malignant neoplasm of brain;Manuscripts;meetings;member;Molecular Biology;multidimensional data;next generation sequencing;novel;Paper;Pathway Analysis;power analysis;preclinical study;Preparation;Productivity;programs;Public Health Schools;Quality Control;Recording of previous events;Reproduction spores;Research;Research Design;Research Personnel;Research Project Grants;Resources;Review Committee;Services;Statistical Data Interpretation;Statistical Methods;Study Section;T cell receptor repertoire sequencing;Tissue Microarray;tool;transcriptome sequencing;Translational Research;translational study;United States National Institutes of Health;whole genome;Work

PROJECT_TITLE: Core 3: Biostatistics and Bioinformatics Core (BBC)


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Rare Diseases

PROJECT_TERMS: anti-cancer research;Award;base;Brain;brain research;cancer prevention;career;Collaborations;Communities;Comprehensive Cancer Center;Data;Development;Diagnosis;Discipline;Ethnic Origin;Faculty;Fostering;Funding;Funding Opportunities;gender diverse;Generations;Goals;Grant;Growth;high reward;high risk;innovation;Institution;interdisciplinary collaboration;Interdisciplinary Study;Malignant neoplasm of brain;medical schools;minority investigator;Mission;Monitor;novel;Outcome;Pilot Projects;Process;Productivity;Program Research Project Grants;programs;Progress Reports;prospective;Qualifying;Race;Request for Applications;Research;Research Institute;Research Personnel;Research Project Grants;Review Committee;Source;success;translational potential;Translational Research;Underrepresented Minority

PROJECT_TITLE: Developmental Research Program


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative The proposed Intellectual and Developmental Disabilities Research Center will support research cores that provide critical resources to 46 established investigators and one signature research project. The combined effort of both the cores and investigators is highly likely to have an important positive impact on research relevant to understanding the pathogenesis and treatment of intellectual and developmental disabilities.

PI_NAMEs: DICHTER, GABRIEL S (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: 2 year old;Address;Affect;Angelman Syndrome;animal imaging;Applied Research;autism spectrum disorder;Basic Science;Behavior;behavior measurement;behavioral phenotyping;Brain;brain behavior;Caliber;Center for Translational Science Activities;Cerebrospinal Fluid;Child;Circulation;Clinical;Clinical Research;Clinical Sciences;Clinical Services;clinical training;clinical translation;Collaborations;collaborative environment;Communities;Complex;cost effective;Data;Data Science Core;Dedications;Development;Developmental Disabilities;Diagnosis;Disability research;Discipline;Early Diagnosis;Early Intervention;educational atmosphere;Environment;Etiology;Family;Fostering;Fragile X Syndrome;Functional disorder;Funding;Genetic;Genomics;Goals;Grant;imaging facilities;Impairment;improved;Individual;Infant;insight;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Interdisciplinary Study;Intervention;Laboratories;Link;Meningeal lymphatic system;Microscopy;mouse model;multidisciplinary;Mus;Nature;Neurodevelopmental Disorder;neuroinflammation;Neurosciences;North Carolina;novel;Participant;Pathogenesis;Pathogenicity;Personal Satisfaction;Phenotype;Play;pre-clinical;predictive marker;Prevention;Prevention strategy;programs;Proteins;Rattus;Registries;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Research Training;Resources;response;Role;Science;Syndrome;synergism;targeted treatment;therapy development;Training;Translational Research;United States National Institutes of Health;Universities

PROJECT_TITLE: Clinical Translational Research Center for Neurodevelopmental Disorders


PROJECT_TERMS: anti-cancer research;Area;Award;Brain Neoplasms;California;career;career development;clinical application;Collaborations;Communities;Creativeness;Dedications;design;Development;Diagnosis;Disabled Persons;Doctor of Philosophy;Early Diagnosis;Education;ethnic minority;Ethnic Population;Evaluation;Faculty;Fostering;Funding;Future;Goals;Grant;Individual;innovation;Institution;interest;Investments;Jonsson Comprehensive Cancer Center of University of California Los Angeles;Malignant neoplasm of brain;medical schools;meetings;member;Mentors;Mentorship;Mission;Monitor;next generation;novel;novel strategies;novel therapeutics;outreach program;peer;Peer Review;peer support;Positioning Attribute;Postdoctoral Fellow;Prevention;Process;programs;Progress Reports;Qualifying;racial minority;racial population;recruit;Research;Research Personnel;Research Project Grants;Research Support;Resources;Review Committee;Scientific Inquiry;Scientist;success;System;Training Programs;translational physician;Translational Research;translational scientist;Translations;Underrepresented Minority;Woman;Work

PROJECT_TITLE: Career Enhancement Program


NIH_SPENDING_CATS: Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

PI_NAMEs: PIVEN, JOSEPH  (contact)

PROJECT_TERMS: Area;autism spectrum disorder;Behavior;Brain;Cell Nucleus;Center for Translational Science Activities;clinical translation;Communication;Communities;Community Outreach;Consult;Core Facility;cost effective;design;Development;Disabled Persons;Discipline;Early Diagnosis;Early Intervention;Education;Environment;Family;Family Research;Fostering;Goals;improved;Individual;Information Technology;Intellectual and Developmental Disabilities Research Centers;Interdisciplinary Study;Leadership;Mentors;Mission;multidisciplinary;Neurodevelopmental Disorder;North Carolina;operation;outreach;Policy Maker;Prevention;programs;quality assurance;recruit;Research;Research Personnel;Research Project Grants;research study;Resources;Science;Scientist;Services;Sum;Syndrome;Training and Education;Training Programs;Translational Research;Underrepresented Minority;United States National Institutes of Health;Universities;Visual;web site


ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE This project will examine the long-term clinical and economic outcomes among working-age survivors of traumatic injury by leveraging a unique data opportunity to combine our statewide trauma registry with commercial credit reports. We will then use policy simulation techniques to evaluate the impact of alternative health insurance design strategies on financial strain and health-related quality of life. Understanding the drivers of poor long-term outcomes and the potential impact of insurance policy redesign will help clinicians, researchers, and policymakers optimize long-term recovery after acute illness or injury.

PI_NAMEs: SCOTT, JONATHAN WILLIAM (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Long-term Trauma Outcomes and Insurance Policy

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Disability Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

PI_NAMEs: BELGER, AYSENIL  (contact)

PROJECT_TERMS: 17 year old;Age;autism spectrum disorder;Behavior;behavior measurement;Behavioral;Behavioral Mechanisms;biopsychosocial;Brain;Brain imaging;Center for Translational Science Activities;Characteristics;Child;Child Development;Clinic;Clinical;clinical development;Clinical Research;clinical translation;clinically relevant;Cognitive;Collaborations;Complex;Computerized Medical Record;Consent;Consultations;Custom;Data;Data Science Core;design;Development;Diagnostic;Diffusion Magnetic Resonance Imaging;Disability research;Disease;Electroencephalography;electronic data;Exposure to;Family;Feedback;Fragile X Syndrome;Functional Magnetic Resonance Imaging;Genetic study;Goals;Grant;guided inquiry;Human;Image;Image Analysis;Imaging Device;improved;Individual;Infant;innovation;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Interdisciplinary Study;Intervention;Laboratories;Magnetic Resonance Imaging;Maps;Measurement;Methodology;Methods;Molecular Genetics;multimodality;Neurodevelopmental Disorder;neuroimaging;Neurosciences;North Carolina;novel;Outcome;Participant;Pathogenesis;Patient Recruitments;Patients;Phenotype;Play;Population;pre-clinical;preclinical study;Preparation;Protocols documentation;Quality of life;Recording of previous events;recruit;Registries;Research;Research Design;Research Personnel;Research Support;Resources;Risk Marker;Sampling;Services;Structure;targeted treatment;tool;Training;Translational Research;Universities;visual tracking

PROJECT_TITLE: Clinical Translational Core


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

PHR: The studies proposed herein are designed to test the feasibility, safety, and preliminary efficacy of a novel bispecific IL-13Rα2/TGF-β CART-T cell therapy for glioblastoma, as well as investigate response biomarkers and mechanisms of immune evasion following the injection of these CAR-T cells intratumorally and intraventricularly. We will test our hypothesis that clinically relevant CAR-T cell therapy for glioblastoma (GBM) must have two components: 1) tumor-specific glioblastoma cell targeting; and 2) blockade of the immunosuppressive tumor microenvironment (TME). We believe that our novel bispecific IL-13Rα2/TGF-β CAR-T cell therapy that simultaneously targets both glioblastoma cells and the immunosuppressive TME may lead to improved outcomes for the treatment of glioblastoma.

PI_NAMEs: CHEN, YVONNE YU-HSUAN (contact)

PROJECT_TERMS: Address;Adoptive Transfer;Adult;Aftercare;aggressive therapy;Antigens;Blood specimen;Brain;CAR T cell therapy;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Proliferation;Cells;Cellular immunotherapy;Cerebrospinal Fluid;Chemotherapy-Oncologic Procedure;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;clinical candidate;clinical efficacy;Clinical Trials;clinically relevant;Cryopreserved Cell;cytokine;cytokine therapy;cytotoxic;Cytotoxic T-Lymphocytes;cytotoxicity;dendritic cell vaccination;density;design;Development;Dominant-Negative Mutation;effective therapy;Effectiveness;engineered T cells;Engineering;Exhibits;experience;feasibility testing;Feedback;first-in-human;Frequencies;Glioblastoma;Glioma;Grant;imaging modality;Immune;Immune Evasion;Immunocompetent;ImmunoPET;immunoreaction;Immunotherapeutic agent;Immunotherapy;improved;improved outcome;in vivo;Infiltration;Infusion procedures;Injections;Interleukin-13;interleukin-13 receptor;Intraventricular;Leukapheresis;Macrophage;Magnetic Resonance Imaging;Maintenance;Malignant Glioma;Malignant neoplasm of brain;manufacture;Methods;Modality;Mus;Myeloid Cells;Myeloid-derived suppressor cells;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;Operative Surgical Procedures;overexpression;patient prognosis;Patient-Focused Outcomes;Patients;Peripheral;Phase I Clinical Trials;Phenotype;Play;Primary Brain Neoplasms;Prognosis;Progression-Free Survivals;Protocols documentation;Qualifying;Radiation;radiological imaging;recruit;Recurrence;Regulatory T-Lymphocyte;Reporting;research clinical testing;resistance mechanism;response;response biomarker;Role;Running;Safety;Sampling;Series;Signal Transduction;single-cell RNA sequencing;small molecule inhibitor;Stimulant;success;T cell therapy;T-Lymphocyte;targeted treatment;Testing;Toxic effect;Toxin Conjugates;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;Transgenes;Treatment Efficacy;Treatment outcome;treatment response;tumor;tumor eradication;tumor microenvironment;Tumor Promotion;Tumor Tissue;Tumor-associated macrophages;tumor-immune system interactions;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Targeting Glioblastoma Cells and Tumor Microenvironment with CAR-T Cell Therapy


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_NAME: MORGAN STATE UNIVERSITY

PHR: PROJECT NARRATIVE The proposed BRIDGE to the Baccalaureate Program at Morgan State University utilizes a wrap-around approach to increase the numbers of underrepresented minorities who successfully complete the transition from Prince George’s Community College to completion of the Baccalaureate degree in STEM and psychology majors at Morgan State University. This will increase the numbers of underrepresented minorities who are then able to successfully compete for positions in graduate or professional programs or who are able to gain entry in the workforce in areas related to biomedical or behavioral sciences.

PI_NAMEs: BROWN, LISA D. (contact);HODGES, AMBER ;TAYLOR, VICTORIA CHRISTINE

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Academic achievement;Academic support;Area;Attention;Awareness;Bachelor's Degree;Behavioral Sciences;bridge to the baccalaureate;career;Collaborations;community college;Discipline;Fostering;Funding;Goals;Institution;interest;Mentors;Positioning Attribute;programs;Psychology;Research;STEM field;student participation;Students;success;Training;transfer student;undergraduate research;Underrepresented Minority;Universities;university student

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Lymphatic Research;Neurosciences;Pediatric

PI_NAMEs: SHEN, MARK D (contact)

PROJECT_TERMS: 4 year old;Address;Age Months;Angelman Syndrome;autism spectrum disorder;Behavior;Behavioral Symptoms;Brain;brain parenchyma;Cells;Center for Translational Science Activities;Central Nervous System;Cerebrospinal Fluid;Child;Circulation;Clinical;clinical phenotype;clinical translation;Clinical Trials;cohort;Data;Development;Developmental Course;Diagnosis;Disease;Disease Progression;Dissection;Drug Delivery Systems;Etiology;Exhibits;Funding;Genes;Growth;Growth Factor;Heterogeneity;Immune system;Impairment;in vivo;Infant;insight;Intellectual and Developmental Disabilities Research Centers;Knowledge;Link;Lymphatic;Lymphatic System;lymphatic vessel;Magnetic Resonance Imaging;mouse model;multidisciplinary;Mus;Neurodevelopmental Disorder;neuroimaging;neuroinflammation;Neurons;neurophysiology;pathogen;Pathogenicity;patient population;Pharmacodynamics;Phenotype;Physiology;Population;potential biomarker;predictive marker;Process;Production;Prospective Studies;Proteins;Reporting;Research;Resources;Rodent Model;Sampling;Severities;Specificity;Subarachnoid Space;Symptoms;Syndrome;Testing;Tracer;Translating;United States National Institutes of Health

PROJECT_TITLE: Cerebrospinal fluid abnormalities in neurodevelopmental disorders


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

PI_NAMEs: MOY, SHERYL S (contact)

PROJECT_TERMS: Angelman Syndrome;animal imaging;Animal Model;Architecture;Ataxia;Atlases;Attention deficit hyperactivity disorder;autism spectrum disorder;Automatic Data Processing;Behavior;behavior test;Behavioral;behavioral phenotyping;behavioral response;Biological Assay;Biological Markers;Brain;brain behavior;Brain imaging;Brain region;brain volume;Caliber;Cells;Center for Translational Science Activities;Childhood;clinical translation;Cognitive;cognitive function;Consultations;Contrast Media;Core Facility;CRISPR/Cas technology;Data;data analysis pipeline;Data Analytics;Data Science Core;developmental disease;Diagnosis;drug discovery;Drug Screening;efficacy testing;electrical microstimulation;Electrophysiology (science);Embryo;emotional functioning;Epilepsy;Evaluation;Faculty;Functional disorder;Genes;Genetic;genetic technology;genome editing;Goals;Grain;Human;Image;Imaging Device;improved;In Vitro;in vivo;Infrastructure;innovation;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Intervention;Joubert syndrome;Laboratories;laboratory experience;laboratory facility;Machine Learning;Magnetic Resonance Imaging;Maps;Measurement;member;method development;Methods;Microscopy;Microtus;migration;model development;Modeling;Molecular;Morphology;Motor;mouse genetics;mouse model;multi-electrode arrays;multi-photon;multidisciplinary;multiphoton imaging;Mus;Neonatal;neural;neural circuit;Neurobiology;neurodevelopment;Neurodevelopmental Disorder;Neuroglia;neuroimaging;Neurons;Neurosciences;novel;optogenetics;Phenotype;Pitt-Hopkins syndrome;pre-clinical;Pre-Clinical Model;Prevention;Regimen;Research;Research Personnel;Resolution;Resources;Rett Syndrome;Science;Sensory;Services;Social Functioning;Source;spatiotemporal;Structure-Activity Relationship;Students;System;Techniques;Testing;Time;Tissues;Training;translational neuroscience;Work

PROJECT_TITLE: Preclinical Core


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Data Science;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

PI_NAMEs: LI, YUN  (contact)

PROJECT_TERMS: Applications Grants;Attention;base;behavior measurement;Behavioral;behavioral study;Bioinformatics;bioinformatics resource;Biological;Biometry;Biostatistical Methods;Brain;Brain imaging;Center for Translational Science Activities;Clinical;Clinical Research;clinical translation;collaborative approach;Complex;Computational Biology;computational neuroscience;computer science;Conceptions;cost effective;Data;Data Analyses;Data Collection;Data Science Core;Data Sources;design;developmental disease;Device or Instrument Development;diagnostic tool;Disability research;Educational Status;Electroencephalography;empowerment;Ensure;epigenomics;experience;Family;Functional Magnetic Resonance Imaging;Genetic;Genomics;high dimensionality;imaging study;Individual;innovation;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Laboratories;longitudinal design;Manuscripts;Massive Parallel Sequencing;Measurement;member;Methods;Modernization;Molecular;multidimensional data;multidisciplinary;multimodality;Multiomic Data;Neurodevelopmental Disorder;personalized intervention;pre-clinical;preclinical study;Preparation;Proteomics;Psychometrics;Quality of life;Reproducibility;Research;Research Design;Research Personnel;research study;Resources;Sample Size;Scientist;Services;Technology;Training;Translational Research;Translations;Validation;Writing

PROJECT_TITLE: Data Science Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: SHREVEPORT

ORG_DEPT: PATHOLOGY

ORG_NAME: LOUISIANA STATE UNIV HSC SHREVEPORT

ORG_STATE: LA

PHR: Project Narrative Patients with stroke are at a significant risk for developing life-threatening venous thromboembolic (VTE) events including deep vein thrombosis (DVT) and pulmonary embolism (PE). Compelling evidence has emerged that implicates neutrophils in the initiation and pathogenesis of DVT. Using experimental models, we will investigate the mechanistic role of neutrophil integrin α9 in modulation of poststroke DVT and test whether targeting integrin α9 reduces DVT incidence following stroke.

PI_NAMEs: DHANESHA, NIRAV  (contact)

PROGRAM_OFFICER_NAME: PHILP, DEBORAH

PROJECT_TERMS: Acute;Adhesions;Adjuvant Therapy;Affect;Age;aged;Aging;Antibodies;Anticoagulants;Anticoagulation;Blood;Blood Platelets;Blood specimen;Bone Marrow Transplantation;CASP1 gene;Cell Adhesion Molecules;clinically relevant;comorbidity;Custom;Data;Deep Vein Thrombosis;Development;embolic stroke;Endothelial Cells;Endothelium;Ensure;Event;Experimental Models;extracellular;Filament;Genetic;Glycocalyx;Hemorrhage;high risk;high risk population;Human;IL8RB gene;In Vitro;in vivo evaluation;Incidence;Infection;Inferior vena cava structure;Inflammasome;inhibitor;integrin alpha9;Integrin Inhibition;Integrins;Ischemic Stroke;Knowledge;Leukocytes;Life;Lymphocyte;male;Microfluidic Microchips;Modeling;Molecular;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;Natural Immunity;Neutropenia;neutrophil;new therapeutic target;novel;old mice;Outcome;Pathogenesis;patient population;Patients;pharmacologic;Pilot Projects;post stroke;Pre-Clinical Model;Predisposition;prevent;prophylactic;Prophylactic treatment;PTK2 gene;Pulmonary Embolism;Regimen;Reproducibility of Results;Risk;Risk Factors;Role;Severities;sex;Signal Pathway;Stenosis;Stroke;stroke model;stroke patient;stroke therapy;Testing;Therapeutic;therapeutic target;Thrombosis;translational impact;Veins;Venous;venous thromboembolism;Venous Thrombosis;Whole Blood

PROJECT_TITLE: Mechanisms for Deep Vein Thrombosis following Stroke

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-C(02)M]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Patient Safety;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: MINDTRACE TECHNOLOGIES, INC.

ORG_STATE: PA

PHR: NARRATIVE MindTrace Technologies, Inc. is developing a cloud-based software platform to be used before, during, and after a neurosurgical procedure to generate evidence that can support the ability of surgeons to remove brain tumors while minimizing damage to critical brain regions that support everyday abilities, like talking, moving, and seeing.

PI_NAMEs: SIMS, MAXWELL HARRISON (contact)

PROGRAM_OFFICER_NAME: GRABB, MARGARET CHRISTINE

PROJECT_TERMS: Area;awake;Behavior;behavior test;Behavioral;Brain;Brain Mapping;Brain Neoplasms;Brain region;Brain scan;brain surgery;brain tissue;brain volume;Breakthrough device;Clinical;clinical decision-making;Clinical Trials;clinically relevant;cloud based;cognitive function;Collaborations;commercialization;Computer software;Craniotomy;Data;Data Collection;Data Correlations;Data Set;design;Development;Effectiveness;Electric Stimulation;Equilibrium;evidence base;Excision;Feedback;Foundations;Functional Magnetic Resonance Imaging;Future;Goals;Health Care Costs;Human Resources;image visualization;imaging modality;Impaired cognition;improved;innovation;Innovation Corps;Institutional Review Boards;Interview;Intuition;Language;Location;Magnetic Resonance Imaging;Malignant Neoplasms;Maps;Materials Testing;Measures;Medical center;meetings;Monitor;Morbidity - disease rate;mortality;motor impairment;MRI Scans;multimodal neuroimaging;neural;neuroimaging;Neuropsychological Tests;Neuropsychology;Neurosurgeon;neurosurgery;Neurosurgical Procedures;Operative Surgical Procedures;optimal treatments;Outcome;Participant;Patients;Performance;Phase;Postoperative Period;Predictive Analytics;Preoperative Care;Procedures;Process;process improvement;Prognostic Factor;prognostic indicator;prospective;Prospective Studies;Protocols documentation;prototype;Quality of life;Reporting;research study;Running;Sensory impairment;Services;Site;Small Business Innovation Research Grant;Source;standard of care;Stream;Structure;Surgeon;symposium;Tablets;Technology;technology development;telehealth;tertiary care;Testing;Time;Tissues;tool;Translating;treatment planning;tumor;Tumor Cell Invasion;Writing

PROJECT_TITLE: Development of an innovative neurosurgical planning tool for awake craniotomy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-Z(10)B]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Rural Health;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE: RELEVANCE TO PUBLIC HEALTH Age restricted in-person location policies (ARLPs), which would restrict the sale of tobacco to adult-only locations (like tobacco shops), are considered a new and exciting approach to reducing tobacco use. Our research is relevant to public health because it would be the first to model the potential impact of ARLPs on youth tobacco use, both overall and for historically marginalized populations that have been negatively affected by the tobacco retailer environment. This project is relevant to NCI’s mission because it would help guide policymakers toward equity-enhancing tobacco control efforts.

PI_NAMEs: ROBERTS, MEGAN ELEANOR (contact)

PROGRAM_OFFICER_NAME: D'ANGELO, HEATHER

PROJECT_TERMS: 21 year old;Address;Adolescent and Young Adult;Adult;Affect;Age;age effect;Alcohols;Behavior;Behavioral;California;Censuses;cohort;Communities;Complex;Connecticut;Data;density;discount;Disparity;disparity reduction;Ecological momentary assessment;Enrollment;Ensure;Environment;Equity;ethnic minority;Ethnic Origin;Evaluation;Exposure to;Focus Groups;follow-up;Geography;Goals;health disparity;health equity promotion;high risk;Income;innovation;Learning;Location;Low income;Low Prevalence;marginalization;marginalized population;Marketing;Mission;Modeling;Neighborhoods;non-cigarette tobacco product;North Carolina;novel;Ohio;Persons;Policies;Policy Maker;Population;Poverty;prevent;Process;Public Health;Qualitative Methods;Race;racial minority;Reaction;reduce tobacco use;Research;Research Personnel;residence;response;Role;Rural;Rural Appalachia;rurality;Sales;Source;Statistical Methods;stem;Subgroup;Survey Methodology;Surveys;Time;Tobacco;tobacco advertising;tobacco control;tobacco prevention;tobacco products;Tobacco use;tobacco user;United States;vaping;willingness;Youth

PROJECT_TITLE: Modeling the equity impact of age restricted in-person location policies for youth tobacco use

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine

PHR: Project Narrative Using deconvolution approaches, we identified two tumor-intrinsic subtypes of PDAC (basal and classical) that are robust, replicable, prognostic and predictive of treatment response. We have also found two stroma subtypes associated with outcome and show tumor-stroma interactions in patients associated with outcome, recapitulated in tumor-CAF models. We will use a combination of cancer biology, computational approaches to determine tumor-stroma interactions and how they predict treatment response.

PI_NAMEs: RASHID, NAIM UR;TSAI, SUSAN ;YEH, JEN JEN  (contact)

PROGRAM_OFFICER_NAME: NOTHWEHR, STEVEN F

PROJECT_TERMS: Affect;Biological Assay;Biometry;Cancer Biology;Cell Communication;cell type;Cells;Characteristics;CLIA certified;Clinic;Clinical;clinical application;Clinical Trials;clinically relevant;Coculture Techniques;Computing Methodologies;Data;Data Set;Desmoplastic;early phase trial;Genes;Heterogeneity;immunoregulation;innovation;kinase inhibitor;Libraries;Manuscripts;Methods;Modeling;Molecular Profiling;molecular subtypes;multidisciplinary;Neoadjuvant Therapy;neoplastic cell;novel;Outcome;patient response;Patient-Focused Outcomes;Patients;Phosphotransferases;Positioning Attribute;predicting response;Prediction of Response to Therapy;Primary Neoplasm;prognostic;Proteome;response;Sampling;Selection for Treatments;Signal Transduction;single-cell RNA sequencing;standard of care;Systemic Therapy;Testing;Therapeutic;transcriptome;transcriptome sequencing;treatment effect;treatment response;tumor;tumor heterogeneity;tumor microenvironment;tumor progression;Tumor Subtype;Validation

PROJECT_TITLE: Integrating tumor and stroma to understand and predict treatment response


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Diabetes;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Our study will identify population-specific risk alleles and improve the risk stratification models for obesity and type-2 diabetes in Native Hawaiians. Moreover, we will reach out to members of the Native Hawaiian community to understand their concerns of participating in genomic research. Together, our research will improve our understanding of genetic risk factors in human complex diseases, provide much needed genomic resources to accelerate future studies, and also provide guidance to the design of future genomic studies in this understudied and underserved population.

PI_NAMEs: CHIANG, CHARLESTON  (contact)

PROGRAM_OFFICER_NAME: MORALES, JOANNELLA

PROJECT_TERMS: Acceleration;Address;Age;Alleles;Asian Americans;biobank;Body mass index;Catalogs;Censuses;Chronic;clinical practice;Communities;Complex;Data;Demographic Impact;design;Diabetes Mellitus;Diet;Disease;disease model;disorder risk;Disparity;East Asian;efficacy evaluation;ethnic minority population;Ethnic Population;European;Exhibits;experience;Focus Groups;Future;Genes;Genetic;genetic architecture;genetic epidemiology;Genetic Research;Genetic Risk;genetic risk factor;Genetic study;Genetic Variation;genome resource;genome sequencing;genome wide association study;genome-wide;Genomics;Genotype;Grant;Habitats;Hawaii;Health;health disparity;High Prevalence;high risk;Historical Demography;Human;improved;Individual;insight;Investigation;Linkage Disequilibrium;member;Meta-Analysis;Metabolic Diseases;Minority Groups;Modeling;modifiable risk;Native Hawaiian;Native Hawaiian or Other Pacific Islander;Natural Selections;non-genetic;Non-Insulin-Dependent Diabetes Mellitus;novel;obese person;Obesity;obesity risk;Oceania;pathogen;Pattern;Phenotype;Philippines;Pilot Projects;Play;polygenic risk score;Polynesian;Population;Population Genetics;Population Heterogeneity;Population Sizes;prevent;programs;prospective;racial population;Recording of previous events;recruit;Research;Resources;Risk;Risk Factors;risk stratification;risk variant;Role;Samoan;sex;Shapes;Socioeconomic Status;statistics;success;Thinking;trait;Underserved Population;United States;Variant;whole genome

PROJECT_TITLE: Leveraging the Evolutionary History to Improve Identification of Trait-Associated Alleles and Risk Stratification Models in Native Hawaiians

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Prevention

ORG_CITY: IOWA CITY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative The IKS channel is a voltage-gated potassium channel that is associated with multiple inherited and acquired cardiac arrhythmias, including long QT syndrome, a leading cause of sudden cardiac death. Despite this, critical information about its regulatory mechanisms (both intrinsic and by the sympathetic nervous system) is still unknown, so development of more effective therapies for these arrhythmias is severely handicapped. The objective of this research is to elucidate the mechanism of the channel and how it is regulated by the sympathetic nervous system, with the goal of identifying new targets for drug development and disease prevention.

PI_NAMEs: SCHENE, MIRANDA  (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Address;Adrenergic Agents;Affect;Amino Acids;Anions;Arrhythmia;Binding;Cardiac Myocytes;career;Cells;Charge;Consensus;Contracts;Core Protein;Cyclic AMP-Dependent Protein Kinases;Data;Dependence;Development;Disabled Persons;disorder prevention;Disparate;drug development;effective therapy;Electrostatics;Fluorometry;Functional disorder;Future;Goals;Heart;heart function;Heart Rate;Hydrophobicity;Immobilization;Individual;Inherited;Investigation;Ion Channel;Ion Channel Gating;Light;Long QT Syndrome;Mammalian Cell;Measures;Membrane;Molecular;Movement;Mutagenesis;Mutate;Mutation;new therapeutic target;novel;novel therapeutics;Outcome;outcome disparities;patch clamp;pharmacologic;Phenylalanine;Phosphorylation;Phosphorylation Site;photolysis;Physicians;Physiologic pulse;Physiological;Play;Positioning Attribute;Potassium;Potassium Channel;prevent;Proteins;Regulation;Relaxation;Research;Resolution;response;Rest;Role;Scientist;sensor;Serine;Signal Transduction;Site;Stimulus;Structure;sudden cardiac death;Sympathetic Nervous System;training opportunity;unnatural amino acids;voltage;voltage clamp;Voltage-Gated Potassium Channel;Work

PROJECT_TITLE: Using a Molecular Toolkit to Examine Potassium Channel Gating and Regulation


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: CAMBRIDGE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: We will develop a completely new class of imaging probes intended for highly sensitive, noninvasive measure- ments of dynamic phenomena in the human brain. Our work will focus on achieving noninvasive brain-wide delivery and high quality detection of neurochemical dynamics, initially in rodents and then in monkeys. Comple- tion of our Aims will establish unprecedented means for analysis of the brain mechanisms that underlie percep- tion and cognition in health and disease.

PI_NAMEs: JASANOFF, ALAN  (contact)

PROGRAM_OFFICER_NAME: WANG, SHUMIN

PROJECT_TERMS: Aging;Animals;Antibodies;Architecture;Autopsy;Behavioral;Biotin;Blood - brain barrier anatomy;blood oxygen level dependent;blood-brain barrier permeabilization;Brain;Bypass;Callithrix;Carrier Proteins;Chemicals;Clinical;Cognition;Contrast Media;Cultured Cells;Data;design;design and construction;Detection;Diffuse;Disease;Dopamine;Drug usage;Engineering;Enzymes;experience;experimental study;Functional Magnetic Resonance Imaging;Glutamates;Goals;Health;hemodynamics;Human;human subject;imaging agent;imaging modality;imaging probe;in vitro testing;in vivo imaging;Injections;intravenous injection;Laboratories;Magnetic Resonance Imaging;Magnetism;Maps;Measurement;Mediating;Methods;Modeling;Molecular;Molecular Probes;molecular scale;Monitor;Monkeys;monoamine;neural circuit;Neurobiology;neurochemistry;neuroimaging;neurophysiology;Neurosciences;Neurotransmitters;non-invasive imaging;nonhuman primate;novel;Optics;Outcome;overexpression;Perception;Peripheral;Permeability;Persons;Positron-Emission Tomography;Primates;Process;Radioactive;Reagent;receptor;research clinical testing;Resolution;response;Rodent;Role;sensor;Signal Transduction;small molecule;Source;spatiotemporal;Specificity;Stimulus;Technology;Testing;Time;transcytosis;translation to humans;ultrasound;Validation;Variant;Work

PROJECT_TITLE: Toward functional molecular neuroimaging using vasoactive probes in human subjects


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: Narrative Infectious diseases remain a leading cause of morbidity and mortality worldwide, and present an ever- increasing threat to human health. The development of new, innovative strategies to combat infectious disease will require research scientists with a depth and breadth of training in both microbiology and immunology, and an appreciation for the needs and realities of clinical care. The purpose of this application is to continue and improve upon a highly successful graduate training program that provides promising predoctoral scientists with the interdisciplinary training and skills required for them to launch successful independent careers in infectious disease research.

PI_NAMEs: WARD, GARY E (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TITLE: Vermont Immunology / Infectious Diseases Training Grant

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Foodborne Illness;Pediatric;Women's Health Research

ORG_CITY: DOVER

ORG_NAME: DELAWARE STATE UNIVERSITY

ORG_STATE: DE

PI_NAMEs: AIKINS, ANTHEA ANITA;MILLIGAN, KIMBERLY ANNE (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Academy;Address;Area;Awareness;Bioinformatics;bioinformatics tool;Biological;Biological Sciences;Biology;career;career preparation;Chemistry;cohort;college;Communities;computerized tools;Computers;cultural competence;Delaware;design;Discipline;Education;Engineering;Ensure;Exercise;expectation;experience;Exposure to;Faculty;field trip;Fostering;Genetic;girls;Goals;graduate student;Health;Historically Black Colleges and Universities;Hour;Human;innovation;interest;junior high school;Laboratories;Laboratory Research;Leadership;lens;Link;Mathematics;Measures;Medicine;member;Microbiology;Middle School Student;Minority;Minority Enrollment;Minority Groups;minority student;Minority Women;Modeling;Molecular Biology;Natural Resources;Participant;Patient Recruitments;preservation;Problem Solving;professional students;programs;Race;Recording of previous events;remediation;Request for Applications;Research;Research Activity;Research Project Grants;Risk Taking;role model;Science;Science, Technology, Engineering and Mathematics;Science, Technology, Engineering and Mathematics Education;Scientist;Self Efficacy;Site Visit;skills;STEM field;Students;success;symposium;teacher;Thinking;undergraduate student;Underrepresented Minority;Underrepresented Populations;Universities;university student;wasting;Water;water solution;water testing;water treatment;Work

PROJECT_TITLE: Biology, Bioinformatics & Chemistry Academy for Research Scholars (B2-CARS): A Partnership to Address Human Health Through Waste Water Remediation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(57)R]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: Urine cadmium and risk of fracture and bone loss Narrative Mechanistic experiments and cross-sectional epidemiologic studies have linked cadmium to low bone mineral density, osteoporosis, and fracture; however, currently lacking are large prospective epidemiologic studies. We propose to leverage existing samples and data from the two largest prospective US osteoporosis cohort studies to perform an in-depth investigation of cadmium, bone loss, and fractures. These studies promise to transform the field of Cd-bone research and have high potential to impact policy decisions in the US and globally.

PI_NAMEs: MELIKER, JAYMIE R (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: adjudication;Affect;Age;aged;Aging;Agreement;Behavioral;Biological Markers;bone;Bone Density;bone loss;bone metabolism;Bone Resorption;Bone structure;bone turnover;Cadmium;Cell Culture System;Clinic Visits;Clinical Data;clinical research site;cohort;Cohort Studies;cost;cost effective;Cotinine;Creatinine;Cross-Sectional Studies;Cyclophosphamide;Data;Diet;dietary;Dual-Energy X-Ray Absorptiometry;Elements;Environment;Environmental sludge;Epidemiology;epidemiology study;Etiology;Excretory function;experimental study;Female;Femur;Fertilizers;Foundations;Fracture;fracture risk;Half-Life;Health;Heavy Metals;hip bone;Human;human old age (65+);Individual;Industrialization;inorganic phosphate;insight;Intake;International;Investigation;Kidney;Link;Longterm Follow-up;male;Measures;Mediating;Mediation;men;Minerals;Morbidity - disease rate;mortality;National Health and Nutrition Examination Survey;Neck;never smoker;novel;Odds Ratio;Organ Culture Techniques;Osmolalities;Osteogenesis;Osteoporosis;osteoporosis with pathological fracture;Persons;Policies;Population;Population Attributable Risks;Prevalence;prospective;Prospective Studies;Public Health;Random Allocation;recruit;Reporting;Research;Research Design;Sampling;Scanning;Serum;Sewage;sex;skeletal;skeletal tissue;Smoking;Smoking History;Soil;Source;Time;Toxic effect;United States;urinary;Urine;Vertebral column;Visit;Woman;working group

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Genetic studies of Alzheimer’s disease have demonstrated a critical pathogenic role for brain immune cells known as microglia, whose function appears to be impaired. This proposal aims to investigate how genetic factors that promote Alzheimer’s disease act to impair microglial function by modifying their long-term responses to inflammatory signals. Our studies will help outline the link between inflammation and Alzheimer’s disease, potentially leading to novel approaches to therapy.

PI_NAMEs: CHATILA, ZENA  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Acetyl Coenzyme A;Address;Adopted;Affect;age related neurodegeneration;alpha ketoglutarate;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid;amyloid pathology;Anti-Inflammatory Agents;Area;ATAC-seq;Automobile Driving;Brain;Brain Pathology;Cell Death;Cell Line;Cells;Central Nervous System;Cholesterol;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;cytokine;Deoxyglucose;Development;Disease;Disease susceptibility;Dose;Epigenetic Process;Equilibrium;established cell line;Exposure to;Failure;Fumarates;Functional disorder;Gene Dosage;Genetic;Genetic Diseases;Genetic Risk;Genetic study;genetic variant;genome editing;genome sequencing;Genotype;glial activation;Glutamates;Glutamine;Glycolysis;Goals;Heterozygote;Human;Immune;immune activation;Immune response;Immunologic Memory;impaired capacity;Impaired cognition;Impairment;imprint;improved;Individual;Inflammation;Inflammatory;insight;interest;Knowledge;Lead;Link;Malates;Measures;Mediating;Memory;Metabolic;Metabolic Pathway;Metabolic stress;Metabolism;Methods;Microglia;Modification;monocyte;mouse model;NADP;Natural Immunity;Nature;neuroinflammation;new therapeutic target;novel;novel strategies;Outcome;Pathogenesis;Pathogenicity;Pathology;Patient-Focused Outcomes;Phagocytosis;Phenotype;Play;Process;Production;protective allele;Pyruvate;Receptor Signaling;Research Personnel;response;risk variant;Role;Shapes;Signal Transduction;Stimulus;Supplementation;tau Proteins;Testing;Therapeutic;Therapeutic Intervention;Training;transcriptome sequencing;transcriptomics;uptake;Variant

PROJECT_TITLE: Alzheimer's Disease Genetic Risk and Microglial Innate Immune Memory


ORG_CITY: ITHACA

ORG_DEPT: CHEMISTRY

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative To assemble complex molecules rapidly, efficiently, and with predictable outcomes is among the most significant challenges in the discovery of new medicinal agents. This proposal addresses several major technological gaps in the field of organic synthesis, and its successful completion will speed the preparation of novel medicinal lead structures.

PI_NAMEs: LIN, SONG  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Electrochemistry as an enabling tool for reaction discovery

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE This proposed research is responding to RFA-CA-21-056 and aims to leverage our decade-long, extensive, and successful training partnership and research collaborations in Mali and Nigeria to implement a novel West African Self-Sampling Human Papillomavirus (HPV)-Based Cervical Cancer Control Program in these two countries. The project capitalizes on existing strengths and resources including the HIV systems of care with Community Health Workers who have established relationships with women living with HIV/AIDS and can provide HPV and cervical cancer education/counseling, guidance for Self-Sampling by women, rapid collection and transport of vaginal swab specimens to hospital laboratories, personalized delivery of test results directly to the women, and facilitation of clinic referrals for those with high-Risk HPV infection for advanced diagnostics and treatment. The study will conduct an in-depth assessment of barriers, challenges, and needs to implement, contextually adapt, and evaluate the effectiveness of the proposed program.

PI_NAMEs: HOLL, JANE LOUISE;HOU, LIFANG  (contact);MAIGA, MAMOUDOU

PROGRAM_OFFICER_NAME: ALARO, JAMES R

PROJECT_TERMS: acceptability and feasibility;Address;Adoption;Africa;Africa South of the Sahara;African;Cancer Control;cancer education;Cancer Etiology;cancer prevention;cancer risk;care systems;Caring;Cervical;Cervical Cancer Education;Cervical Cancer Screening;cervical carcinogenesis;cervicovaginal;Cessation of life;Clinic;Clinic Visits;Clinical;co-infection;Collaborations;collaborative approach;Collection;Communication difficulty;Community Health Aides;Competence;cost;cost effective;Counseling;Country;Cytology;dashboard;Data;Diagnostic;Diagnostic tests;DNA;Early Diagnosis;Early treatment;effectiveness evaluation;evidence base;experience;Face;Female;Funding;health care settings;Health system;high risk;HIV;HIV Infections;HIV Seronegativity;HIV/AIDS;Home;hospital laboratories;HPV-High Risk;Human papilloma virus infection;human papilloma virus oncogene;Human Papilloma Virus Vaccination;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Immune Evasion;Immunosuppression;implementation fidelity;implementation framework;implementation strategy;improved;Incidence;Income;Infection;Infrastructure;Knowledge;Laboratories;Learning;low and middle-income countries;Maintenance;Mali;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Methods;Muslim population group;Needs Assessment;Nigeria;novel;Oncogene Activation;Patients;Persons;Prevalence;Prevention strategy;Process;programs;Recommendation;Religion;Reporting;Research;Resources;Risk Assessment;sample collection;Sampling;scale up;screening;Screening for cancer;Secure;Sexually Transmitted Diseases;Site;social;social culture;social stigma;Specimen;success;Surveys;Swab;Target Populations;Temperature;Test Result;Testing;Training;Transportation;United States National Institutes of Health;Vagina;webinar;Woman;Women's Health

PROJECT_TITLE: West Africa Self-Sampling HPV Based Cervical Cancer Control Program (WA-SS-HCCP) for WLWHA: Barriers, challenges, and needs


ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE During the prior cycle of the BWH CCCR, VERITY, helped produce 160 original articles, which have already been cited 1287 times. The three Cores have been extremely productive and learned much about working effectively with the Research Community. The proposed aims build on the prior successes with: an enhanced Enrichment Program increasing the focus on under-represented minority researchers in rheumatology; a Methodology Core that ensures methodologic rigor while incorporating behavioral theory and economics into studies focused on racial and ethnic minorities; and a Bioinformatics Core that provides bioinformatic support to better phenotype patient cohorts, allowing for studies of social determinants of health.

PI_NAMEs: SOLOMON, DANIEL HAL (contact)

PROGRAM_OFFICER_NAME: GREEN PARKER, MELISSA C

PROJECT_TERMS: Adult;advanced analytics;Behavioral;behavioral economics;Bioinformatics;bioinformatics resource;Case Study;Childhood;Clinical;Clinical Investigator;Clinical Research;cohort;Communities;Conduct Clinical Trials;COVID-19 pandemic;Data;data integration;design;Economics;Ensure;ethnic minority;Faculty;Future;Grant;Hospitals;improved outcome;Intervention;Journals;Learning;Machine Learning;Mentors;Mentorship;Methodology;Methods;minority investigator;Musculoskeletal;Musculoskeletal Diseases;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;next generation;Paper;Patients;Perception;Persons;Phenotype;phenotypic data;Productivity;programs;Publications;racial minority;recruit;Research;Research Personnel;Research Project Grants;research study;Research Support;Research Training;Resources;Rheumatism;rheumatologist;Rheumatology;service utilization;Services;skills;social health determinants;Stream;success;theories;tool;Training;treatment effect;Underrepresented Minority;Woman;Work

PROJECT_TITLE: VERITY: Value and Evidence in Rheumatology using bioInformaTics, and advanced analYtics


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease

PROJECT_TERMS: Adult;advanced analytics;Advisory Committees;Award;Bioinformatics;bioinformatics resource;Boston;Budgets;career development;Childhood;Clinical;clinical center;Clinical Investigator;Clinical Research;Collaborations;Committee Members;Communities;cost;Country;Data;Distance Learning;Education;Educational process of instructing;Ensure;experience;Faculty;faculty mentor;Funding;Goals;Grant;Hospitals;Hybrids;improved;innovation;Leadership;Mediation;medical schools;meetings;Mentors;Methodology;Methods;Mission;Musculoskeletal;Musculoskeletal Diseases;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Natural Language Processing;next generation;Online Systems;pedagogy;Personnel Management;Persons;programs;Recovery;Research;Research Methodology;Research Personnel;Resources;Rheumatism;rheumatologist;Rheumatology;Rotation;Series;Services;Site;Stream;success;Surveys;synergism;Teacher Professional Development;Training;treatment and outcome;Underrepresented Minority;virtual;Woman;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health

PI_NAMEs: LOSINA, ELENA  (contact)

PROJECT_TERMS: Accounting;Address;advanced analytics;Affect;Area;Behavior Therapy;Behavioral;behavioral economics;Biochemical;Bioinformatics;Caring;Clinical;clinical care;clinical practice;Clinical Research;Communities;comorbidity;comparative effectiveness study;Complex;Computerized Medical Record;Conduct Clinical Trials;Consultations;cost;cost effectiveness;Data;Data Analyses;data management;data privacy;Data Security;Data Sources;design;disparity reduction;diverse data;efficacious treatment;electronic data;Ensure;Epidemiology;Equilibrium;Ethics;ethnic minority;experience;Faculty;Geography;Goals;Grant;Health;health care disparity;Health Promotion;Healthcare;Heterogeneity;illness length;imaging biomarker;implicit bias;improved;improved outcome;Information Technology;innovation;insight;instrument;Intervention;Intervention Trial;joint destruction;Language;Level of Evidence;Link;Machine Learning;Manuscripts;marginalization;Mediation;member;method development;Methodology;Methods;Monitor;multidisciplinary;Musculoskeletal;Musculoskeletal Diseases;novel;Observational Study;Online Systems;Outcome;Outcome Assessment;Outcome Measure;patient engagement;patient oriented;Patients;Perception;Persons;Phenotype;Physical activity;Population;Positioning Attribute;preference;Quality of Care;Quality of life;racial minority;Randomized;randomized, clinical trials;Randomized, Controlled Trials;recruit;Registries;Regulation;Reporting;Research;Research Design;Research Methodology;Resources;Rheumatism;Rheumatology;Risk Factors;Role;Secure;social health determinants;social influence;social media;Social Network;Source;Statistical Data Interpretation;Symptoms;theories;Time;tool;Toxic effect;wearable device;Work

PROJECT_TITLE: Methodologic Core


PHR: PROJECT NARRATIVE Some patients who undergo inter-hospital transfer (IHT, transfer from one hospital to another) may be exposed to the risks of discontinuity of care without clear benefit from care received following transfer (i.e., undergo potentially inappropriate IHT). Without a reliable method for defining and determining the presence of potentially inappropriate IHT across many organizations, it is not otherwise possible to understand the safety impact of these transfers, to create and optimize future solutions to reduce them, or to directly test the effects of these solutions on patient outcomes. Our study addresses these issues by seeking to accurately define and estimate the incidence and patient safety impact of potentially inappropriate IHT among medical patients who have undergone IHT to a large network of US hospitals, characterize and identify at-risk patients, and develop a toolkit of best practices to reduce potentially inappropriate IHT for future dissemination (e.g., by replacing it with safer alternatives).

PI_NAMEs: MUELLER, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: SHERMAN, HEATHER

PROJECT_TITLE: Identification and Prevention of Potentially Inappropriate Inter-hospital Transfers

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Social Determinants of Health

PI_NAMEs: LIAO, KATHERINE PHOENIX (contact)

PROJECT_TERMS: Adult;advanced analytics;Area;Automobile Driving;Bioinformatics;bioinformatics resource;causal model;Childhood;Clinical Data;Clinical Investigator;Clinical Research;Collaborations;Communities;Computerized Medical Record;Consultations;Data;data integration;data sharing;design;Development;disease model;Disease Outcome;disorder risk;Education;EFRAC;experience;Faculty;Feasibility Studies;federated learning;Fostering;Foundations;Grant;health equity;Institution;interest;Learning;Machine Learning;medical schools;Methodology;Methods;Mission;Musculoskeletal;Musculoskeletal Diseases;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Natural Language Processing;Patient Care;Patient-Focused Outcomes;Phenotype;Pilot Projects;programs;Publishing;Research;Research Personnel;research study;Resources;Rheumatism;Rheumatology;Services;social health determinants;supervised learning;Technology;tool;treatment effect;unsupervised learning;Work

PROJECT_TITLE: Bionformatics Resource Core


ORG_CITY: PORTLAND

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative MammoScreen is a web-based application for women ages 40-74 that identifies risks for breast cancer and guides decisions about mammography screening and genetic counseling in accordance with current clinical recommendations. To improve patient care in health systems, information entered by women in MammoScreen could be transferred directly to clinicians through the electronic health record (EHR), although methods to accomplish this have not yet been developed. This project leverages new, secure health data methods to integrate MammoScreen with compatible EHRs, allowing clinicians to access patient-generated breast cancer risk data and provide appropriate care.

PI_NAMEs: EDEN, KAREN BEEKMAN (contact)

PROGRAM_OFFICER_NAME: PATEL, SHEENA

PROJECT_TITLE: Implementing USPSTF Recommendations for Breast Cancer Screening and Prevention by Integrating Clinical Decision Support Tools with the Electronic Health Record


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Chronic Pain;Clinical Research;Dental, Oral, and Craniofacial Disease;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Chronic eye pain is a highly distressing symptom as its occurrence results in high disability without effective treatment. Such pain can be driven by ongoing inflammation, but it can also be a result of damage to the sensory nervous system. In this program, we distinguish the difference between these two sources of pain using advanced neuroimaging to evaluate the peripheral and central nervous system pathways that innervate the eye. This first-of-its-kind study will provide invaluable information that can be applied towards the diagnosis, monitoring and treatment of persons with chronic eye pain.

PI_NAMEs: MOULTON, ERIC ALAN (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Adult;Affect;Affective;Age;Amygdaloid structure;Anatomy;Animal Model;Anterior;Anti-Inflammatory Agents;aqueous;base;blood oxygenation level dependent response;Brain;Brain imaging;brain morphology;Brain region;Brain Stem;Central Nervous System;central pain;central sensitization;Chronic;chronic neuropathic pain;chronic pain;Classification;Clinical;clinical decision-making;clinical diagnosis;clinical diagnostics;clinical phenotype;Clinical Research;comorbidity;Complex;Confocal Microscopy;Cornea;Data;density;Diagnosis;diagnostic biomarker;Diffusion Magnetic Resonance Imaging;disability;Disease;disease phenotype;Distress;effective therapy;Emotions;Event;Exhibits;Eye;eye dryness;Foundations;Functional Magnetic Resonance Imaging;Future;Goals;Human;Immune;improved;in vivo;Individual;Inflammation;Inflammatory;inflammatory pain;Infrastructure;Insula of Reil;Investigation;Knowledge;lens;Lesion;Light;Lubrication;Machine Learning;Magnetic Resonance Imaging;Measures;Mechanics;Mental Health;Microscopy;Modeling;Monitor;Morbidity - disease rate;Morphology;multimodality;Nerve;Nerve Fibers;nerve supply;Nervous System;neural circuit;neural network;Neural Pathways;neuroimaging;Neurologic;neuromechanism;Neuropathy;Nociception;ocular pain;Pain;pain processing;pain symptom;painful neuropathy;Pathology;Pathway interactions;Patient Monitoring;Patients;Peripheral;Peripheral Nerves;Peripheral Nervous System;Persons;Phenotype;Photophobia;physical conditioning;Population;Positioning Attribute;programs;reflectance confocal microscopy;Research;response;Rest;Sensory;sex;Sjogren's Syndrome;somatosensory;Source;spontaneous pain;Stains;Stimulus;Structure;Structure of trigeminal ganglion;Symptoms;System;Techniques;Testing;Therapeutic Effect;tissue injury;tool;Translational Research;Trigeminal nerve structure;Trigeminal System;white matter

PROJECT_TITLE: Differentiation of Clinical Phenotypes of Inflammatory and Neuropathic Ocular Pain Conditions with Morphologic Measures and Functional Brain Imaging


NIH_SPENDING_CATS: Duchenne/ Becker Muscular Dystrophy;Muscular Dystrophy;Orphan Drug;Osteoporosis;Pediatric;Rare Diseases

ORG_DEPT: ORTHOPEDICS

PHR: Project Narrative The purpose of this project is to evaluate the efficacy and study the mechanisms of its actions of oral nitrite administration as a novel therapeutic approach to replenish NO in dystrophic muscle by targeting nitrate-nitrite-NO pathway, which is significantly disturbed in DMD. The unique beneficial effects of nitrite to both dystrophic skeletal muscle and bone tissues represent a novel intervention targeting musculoskeletal comorbidities in DMD. If succeed, this innovative strategy could represent a safe and cost-effective therapeutic pharmacological approach benefiting both muscle and bone for the currently untreatable DMD; and provide new mechanistic understanding of DMD muscle and bone pathogenesis in DMD.

PI_NAMEs: LI, HONGSHUAI  (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Affect;Anions;Arginine;Attenuated;Biological Availability;Blood;bone;bone cell;bone loss;bone quality;Bone Tissue;Brain Hypoxia-Ischemia;Bypass;Cells;Clinical Trials;Combined Modality Therapy;comorbidity;cost;cost effective;cranium;curative treatments;Cyclic GMP;Data;dietary nitrate;Dietary Nitrite;Disease;Disease Progression;Duchenne muscular dystrophy;Dystrophin;effective therapy;efficacy evaluation;efficacy testing;extend lifespan;fibroblast growth factor 21;gain of function;Genes;Hindlimb Suspension;Histologic;Homeostasis;Human;improved;in vivo;inhibitor;innovation;insight;Intervention;Investigation;Ischemia;Knock-out;Knowledge;life span;Liver;Measures;mechanical load;Mediating;Molecular;mouse model;Mus;Muscle;Muscle Cells;Muscle Fibers;Muscle function;Muscular Dystrophies;Musculoskeletal;Mutation;Myocardium;Myoglobin;Myopathy;Neuromuscular Diseases;neuron loss;neutralizing antibody;new therapeutic target;Nitrates;Nitric Oxide;Nitric Oxide Pathway;Nitric Oxide Signaling Pathway;Nitric Oxide Synthase;Nitric Oxide Synthase Type I;Nitrites;Nitrogen Dioxide;novel;novel therapeutic intervention;novel therapeutics;Oral;Oral Administration;Organ Culture Techniques;Osteoporosis;Outcome;Oxygen;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;pharmacologic;phosphoric diester hydrolase;Physiological;potential biomarker;pre-clinical;preservation;Production;Proliferating;Recombinant Fibroblast Growth Factor;Recycling;Role;Series;Signal Pathway;Signal Transduction;Signaling Molecule;Skeletal bone;Skeletal Muscle;skeletal muscle differentiation;Source;Testing;Therapeutic;Therapeutic Effect;therapeutic target;therapeutically effective;Tissues;Utrophin

PROJECT_TITLE: Targeting Nitrate-Nitrite-NO pathway for Ameliorating Muscle and Bone Comorbidities in Duchenne Muscular Dystrophy

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Genetics

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Relevance to public health: Mutations in genes encoding sodium proton exchangers found in the membranes of endosomes and lysosomes of the cell cause serious disorders ranging from syndromic autism and intellectual disability to various cancers. This project will biochemically map sodium and proton transport activity in these intracellular compartments for the first time and link gene variants and gene expression in patient populations to clinical phenotypes to understand the molecular basis of disease.

PI_NAMEs: KRISHNAN, YAMUNA ;MIRSHAHI, TOORAJ ;RAO, RAJINI  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: autism spectrum disorder;Biochemical;bioinformatics tool;Biological;Biological Assay;Case Study;Cations;Cell membrane;Cell Physiology;Cells;Chicago;Clinical;clinical effect;clinical phenotype;clinically significant;cohort;Correlation Studies;Databases;design;Disease;Dominant-Negative Mutation;Electronic Health Record;endosome membrane;Endosomes;exome sequencing;Family;follow-up;Gene Expression;Genes;genetic association;Genetic Polymorphism;genetic variant;Genome;genomic locus;Genotype;Human;imaging modality;Individual;Inflammatory Bowel Diseases;insight;Intellectual functioning disability;Ion Transport;Ions;Lead;Link;loss of function;Lysosomes;Malignant neoplasm of brain;Malignant Neoplasms;Maps;Measurement;Measures;member;Membrane;Meta-Analysis;Methods;Modeling;Molecular;Mutation;Myocardial;NHE1;novel;Organelles;Pathologic;Pathway interactions;patient population;Patients;Pattern;Phenotype;Physiology;Population;Protein Isoforms;Protons;Public Health;Quantitative Trait Loci;Reporter;Reporting;Research;Resources;risk variant;Role;Sodium;Sorting;Technology;Testing;therapeutic target;Time;Tissues;tool;trafficking;trait;Variant;Vesicle;Vision

PROJECT_TITLE: Mechanism and function of intracellular sodium-proton exchangers

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Kidney Disease;Precision Medicine;Prevention;Social Determinants of Health

PHR: Project narrative/Public Health relevance The proposed K01 award “Advancing equitable implementation of genomic medicine in nephrology” responds to the NIDDK’s research priorities related to filling a critical gap between the discovery of novel genes in nephrology and the limited utilization of those discoveries in practice; this gap prevents personalization of care of all patients with kidney diseases, many of whom are from underserved racial/ethnic communities. To fill this gap, this study will identify barriers to genetic testing in nephrology and develop and test a point-of-care toolbox focused on genomic literacy—a key barrier for uptake of genetic testing. This K01 will prepare the candidate to develop an independent research program in implementation science and health equity research and generate innovative interventions to accelerate equitable implementation of genomic medicine in nephrology.

PI_NAMEs: MILO RASOULY, HILA  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Acceleration;Address;Adoption;arm;Characteristics;Chronic Kidney Failure;Clinic;Clinical;clinical care;clinical practice;cohort;Collaborations;Communication Research;Communities;Competence;computer human interaction;Data;design;Development;Dissemination and Implementation;Doctor of Philosophy;Educational Status;efficacy trial;Ensure;Environment;Equity;ethical, legal, and social implication;ethnic minority;Ethnic Origin;experience;Feasibility Studies;feasibility testing;Foundations;Funding;Future;future implementation;Genes;Genetic;Genetic Counseling;genetic counselor;Genetic Determinism;genetic disorder diagnosis;genetic testing;Genomic medicine;Genomics;Goals;Grant;Guidelines;health communication;health disparity;Health education;Health equity research;health literacy;Healthcare Systems;High Prevalence;implementation framework;implementation research;implementation science;implementation strategy;improved;innovation;International;Intervention;Interview;Investments;Kidney;kidney biopsy;Kidney Diseases;Knowledge;Lead;Learning;literacy;marginalization;Measures;Medical Genetics;Mentored Research Scientist Development Award;Mentors;Mentorship;Methods;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;novel;Online Systems;Outcome;Participant;Pathology;patient engagement;patient screening;Patients;personalized care;pilot test;point of care;Population;post-doctoral training;practice setting;pragmatic study;precision medicine;prevent;programs;prospective;Prospective Studies;Provider;public health relevance;Qualitative Research;Race;racial minority;Recommendation;Research;Research Methodology;Research Personnel;Research Priority;Research Training;Resources;Respondent;screening;secondary outcome;skills;social determinants;socioeconomics;Spanish;statistics;Strategic Planning;structural determinants;Surveys;symposium;Testing;theories;tool;Training;Translating;translational genetics;translational genomics;United States National Institutes of Health;Universities;uptake

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE: Major questions in cell biology can only be answered with the development of new technology. We have developed methods to image single molecules of messenger RNA and proteins in living yeast cells in order to understand how information is regulated in the cell. We have found that these molecules regulate cell growth by making proteins at exactly the right time and place and then disappear, promoting the precise timing needed for cell division. The goal of this proposal is to develop methods to visualize the life cycle of a single mRNA molecule in real time in living cells.

PI_NAMEs: SINGER, ROBERT H (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Address;Binding Proteins;Birth;Cell Cycle;Cell division;cell growth;Cell Nucleus;Cells;Cellular biology;Cessation of life;Crowding;Cytoplasm;Development;Funding;Genetic Transcription;Goals;Grant;Image;Life Cycle Stages;Messenger RNA;Methods;mRNA Transcript Degradation;new technology;novel strategies;Photobleaching;Process;Proteins;real-time images;Resolution;Scheme;single molecule;Time;tool;Translating;Translations;Visualization;Yeasts

PROJECT_TITLE: Following mRNA from birth to death at single-molecule resolution

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Rare Diseases

ORG_CITY: BETHESDA

ORG_NAME: HENRY M. JACKSON FDN FOR THE ADV MIL/MED

PHR: Project Narrative The project is focused on the in vivo regulation of cytoplasmic dynein, a motor that drives many cellular cargoes. In elongated cells such as neurons, long-distance cargo transport by dynein is critical for cell survival, and dynein deficiencies cause devastating neurodegenerative diseases, for example, Amyotrophic lateral sclerosis (ALS). Dynein is also important for brain development. Deficiencies in the dynein regulator LIS1 cause a brain developmental disorder called “lissencephaly” manifested by mental retardation and early death. Elucidating the regulatory mechanism of dynein will potentially benefit the development of therapies for these human diseases

PI_NAMEs: XIANG, XIN  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Adaptor Signaling Protein;Amyotrophic Lateral Sclerosis;Area;Aspergillus;Aspergillus nidulans;Brain;Cell Survival;Cells;Cessation of life;Collaborations;Complex;Cytoplasm;Data;Development;developmental disease;dynactin;Dynein ATPase;Early Endosome;Eukaryotic Cell;experimental study;Genetic;genome sequencing;human disease;In Vitro;in vivo;insight;Kinesin;LIS1 protein;lissencephaly;live cell imaging;Location;Mental Retardation;Messenger RNA;Microtubules;Minus End of the Microtubule;Molds;Molecular Conformation;Motor;Neurodegenerative Disorders;Neurons;Organelles;Physiological;Plus End of the Microtubule;premature;prevent;Process;Proteins;Proteomics;Regulation;Research;Scientist;System;therapy development;Vesicle;Virion;Virus Diseases;whole genome;Work

PROJECT_TITLE: Regulation of cytoplasmic dynein in vivo


NIH_SPENDING_CATS: Brain Disorders;Emerging Infectious Diseases;Hearing Loss;Infectious Diseases;Neurosciences;Pediatric;Prevention

ORG_CITY: STANFORD

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE Viral infection is a common cause of sensorineural hearing loss (SNHL), however studies have not conclusively identified the etiology. This study will establish in vivo mouse models for SNHL caused by mumps virus and cytomegalovirus using a controlled and local viral injection method. Cochlear damage will be assessed at the cellular to molecular level and the role of immune responses will be characterized with the goal of advancing knowledge of the mechanisms leading to virus-induced SNHL to provide future prevention and treatments in human patients.

PI_NAMEs: KUBOTA, MARIE  (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: Acute;Address;Affect;Anatomy;Animal Model;animal model development;Anti-viral Agents;Antibodies;Apical;Apoptosis;Apoptotic;Auditory;Auditory Brainstem Responses;Auditory system;base;Betaherpesvirinae;Biological Assay;Biology;biomarker identification;Birth;C57BL/6 Mouse;career;Cell Count;cell injury;cell type;Cells;Chronic;Cochlea;Collaborations;Confocal Microscopy;Cytomegalovirus;Cytomegalovirus Infections;Development;Disease;Double Stranded DNA Virus;Embryonic Development;Equipment and supply inventories;Etiology;Evaluation;experience;Experimental Animal Model;Family;Foundations;Future;ganglion cell;Gangliosides;Generations;Goals;Hair Cells;hearing impairment;Herpesviridae;Histocytochemistry;Histopathology;Human;Immune;immune cell infiltrate;Immune response;improved outcome;in vivo;in vivo Model;Inbred BALB C Mice;Infection;Injections;Inner Ear Infection;Integration Host Factors;interferon alpha receptor;Interferon Type I;Knowledge;Labyrinth;Lassa virus;Lead;Lesion;Location;Measures;Medical;Methods;Modeling;Molecular;mouse model;Mumps virus;Murid herpesvirus 1;Mus;Neonatal;neonatal mice;Neuroglia;Neurons;novel;otoacoustic emission;ototoxicity;Paramyxovirus;pathogen;Pathogenesis;Pathologic;Pathology;Patients;postnatal;Predisposition;Prevention;Preventive treatment;Principal Investigator;Protocols documentation;Reporting;Research;Research Personnel;Research Training;RNA Viruses;Rodent;Role;Scientist;Sensorineural Hearing Loss;spiral ganglion;Steroids;Structure of posterior semicircular canal;Supporting Cell;Systemic infection;Testing;Texas;Tissues;Universities;Viral;viral detection;Viral load measurement;Viral Pathogenesis;Viral Proteins;virology;Virulence;Virus;Virus Diseases;Virus Receptors;Work

PROJECT_TITLE: Molecular etiology of virus-induced sensorineural hearing loss

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]