PI_NAMEs: FRANCHINI, GENOVEFFA  (contact)

PROJECT_TERMS: Ablation;Aborigine;Actins;Acute;Adult T-Cell Leukemia/Lymphoma;Affect;Alveolitis;Animals;Apoptotic;Arthritis;Australia;Autoimmune;Automobile Driving;B-Lymphocytes;Blood;Bronchiectasis;Bronchoalveolar Lavage;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Chimeric Proteins;chronic infection;Collaborations;Communities;Coupled;Cytotoxic T-Lymphocytes;Data;Dermatitis;Disease;DNA;DNA Sequence Alteration;druggable target;Early Intervention;Equilibrium;Exons;Exposure to;Fibrosis;fibrotic lung disease;Genetic;Genetic Transcription;Goals;Hemorrhage;Human;human model;Human T-lymphotropic virus 1;Immune;Immunity;Impairment;in silico;In Vitro;in vivo;Indigenous;Individual;Induction of Apoptosis;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Initiator Codon;Interstitial Pneumonia;Jurkat Cells;Knock-out;leukemia;Link;Lung;lung development;Lung Diseases;lung injury;Macaca;Measures;Melanesia;Messenger RNA;Modeling;Molecular Cloning;monocyte;Morbidity - disease rate;mortality;Motility;Mucous Membrane;Natural Killer Cells;Nerve Degeneration;Neurodegenerative Disorders;Northern Territory;Onset of illness;Open Reading Frames;pathogen;Pathogenicity;Pathway interactions;Peripheral;Population;prevent;Preventive;Proteins;Pulmonary Inflammation;Research;Resistance;response;Retroviridae;RNA Splicing;RNA vaccine;Role;Seroprevalences;Signal Transduction;Site;Smooth Muscle;Spinal Cord Diseases;T cell infiltration;T-Lymphocyte;Testing;therapeutic evaluation;Tissue-Specific Gene Expression;Translation Initiation;Translations;Tropical Spastic Paraparesis;Uveitis;Vaccines;Variant;Vertebral column;Viral;Viral Proteins;viral rescue;viral transmission;Virus;Virus Diseases

PROJECT_TITLE: Role of the HTLV-1A and HTLV1-C inflammatory profile in disease


ACTIVITY: ZIA

ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hepatitis;Liver Disease;Prevention

ORG_NAME: DIVISION OF BASIC SCIENCES - NCI

PI_NAMEs: GONZALEZ, FRANK J (contact)

PROJECT_TERMS: Bile Acids;cancer biomarkers;cancer chemoprevention;Carbon Tetrachloride;Carcinogens;CCAAT-Enhancer-Binding Protein-alpha;Cell Physiology;Chemicals;Cholesterol;Cirrhosis;cytokine;Dependovirus;Development;Diet;Disease;Embryo;Enterobacteria phage P1 Cre recombinase;Fatty acid glycerol esters;FDA approved;fibrogenesis;Fibrosis;Fructose;Gene Expression;Genes;Goals;Hepatic;Hepatic Stellate Cell;Hepatocyte;Homeostasis;Human;Knock-out;Knockout Mice;lipidomics;Lipids;Liver;liver development;Liver diseases;Liver Fibrosis;liver function;Mass Spectrum Analysis;Messenger RNA;Metabolic Diseases;Metabolic dysfunction;Metabolic Pathway;metabolomics;Modeling;Molecular;mouse model;Mus;Neonatal;non-alcoholic fatty liver disease;novel therapeutic intervention;Onset of illness;osteopontin;overexpression;Pathologic;Pharmaceutical Preparations;Primary carcinoma of the liver cells;programs;Publications;Publishing;Repression;Risk Factors;Role;Serotyping;Steatohepatitis;Tamoxifen;Tissues;toxicant;Xenobiotic Metabolism

PROJECT_TITLE: Xenobiotic metabolism, cancer chemoprevention and cancer biomarkers


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

PI_NAMEs: WAKEFIELD, LALAGE  (contact)

PROJECT_TERMS: Allografting;antagonist;Binding Sites;Biological;breast cancer progression;cancer stem cell;cancer therapy;carcinogenesis;carcinogenicity;Cell Count;cell type;Cells;Characteristics;chemotherapy;Chromatin;Clinical;Complex;Crowding;data acquisition;Development;functional genomics;Functional Imaging;Genetic Enhancer Element;genetic regulatory protein;Goals;Human;imaging approach;In Situ;In Vitro;in vivo;Individual;insight;lung metastatic;Malignant Breast Neoplasm;Maps;Methods;Minority;Modeling;Molecular;Monitor;mouse model;Mus;Neoplasm Metastasis;novel;Nutrient;Patients;Play;Population;Pre-Clinical Model;preservation;prevent;Process;promoter;receptor expression;Recovery;Reporter;Resistance;response;rho GTP-Binding Proteins;Role;Sampling;sensor;Signal Transduction;Site;stem;Testing;Therapeutic;Time;transcription factor;Transducers;Transforming Growth Factor beta;Transforming Growth Factor Beta 2;Transgenic Model;tumor;tumor progression;Tumor Promotion;tumorigenesis;Visualization;Xenograft procedure

PROJECT_TITLE: TGF-betas in breast cancer progression


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Hepatitis - B;Hepatitis - C;Infectious Diseases;Liver Cancer;Liver Disease;Microbiome;Rare Diseases

PI_NAMEs: WANG, XIN WEI  (contact)

PROJECT_TERMS: Adenoviruses;Animal Model;Anti-viral Response;Antigen Presentation;Area;B-Lymphocytes;Binding Proteins;carcinogenesis;Cell Death;Centrosome;Chromosomal Instability;Chronic;chronic liver disease;Complex;Development;Docking;Etiology;Gene Expression;Gene Expression Profile;Genes;Genomic Instability;Goals;Hepatitis;Hepatitis B Virus;Hepatitis C;Hepatitis C virus;Hepatitis Delta Virus;Hepatocarcinogenesis;Hepatocyte;Homeostasis;Human;Immunity;Inflammation;Interferons;Link;Liver;Mediating;microbiota;Mitosis;Mitotic spindle;Molecular;Molecular Profiling;Natural regeneration;novel;Nuclear Export;nucleocytoplasmic transport;nucleophosmin;Oncogenic;Pathogenesis;Pathway interactions;Patients;Pilot Projects;Play;prevent;Primary carcinoma of the liver cells;Proteins;ran-binding protein 1;Research;Role;Running;Sampling;Signal Transduction;Tissues;tool;Viral hepatitis;Viral Physiology;Viral Proteins;Virus;virus core;Virus Diseases

PROJECT_TITLE: Roles of microbiota-mediated hepatocarcinogenesis


NIH_SPENDING_CATS: Cancer;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Precision Medicine;Rare Diseases

PI_NAMEs: POMMIER, YVES  (contact)

PROJECT_TERMS: Acyclovir;adduct;Adrenal Gland Cancer;anti-cancer research;Antineoplastic Agents;Antineoplastic Combined Chemotherapy Protocols;APEXL2 Gene;Apoptosis;arginine methyltransferase;Ataxia Telangiectasia;base;Binding;Biochemical;Biological Assay;biomarker signature;cancer cell;Cancer cell line;cancer therapy;carcinogenicity;CCR;CDT1 Gene;Cell Cycle Checkpoint;Cell Death;Cell Line;Cells;CHEK1 gene;Chromatin;Clinic;Clinical;clinical development;Clinical Pharmacology;Clinical Trials;clinically relevant;Collaborations;Communities;Complex;Crystallography;Cytarabine;Databases;Digestion;DNA;DNA biosynthesis;DNA Damage;DNA Markers;DNA Repair;DNA replication fork;DNA Synthesis Inhibitors;DNA-protein crosslink;drug candidate;Drug Combinations;drug response prediction;Drug Targeting;drug testing;endonuclease;Enzymes;epigenetic drug;ERCC1 gene;Excision;FDA approved;Genes;genomic data;genomic signature;Genomics;Glycoside Hydrolases;Histone Deacetylase Inhibitor;homologous recombination;homologous recombination deficiency;Hydrolysis;Immune checkpoint inhibitor;improved;Induction of Apoptosis;inhibitor;kinase inhibitor;Knock-out;Licensing Factor;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Manuscripts;Mediating;Methylation;mitochondrial genome;Molecular;Molecular Mechanisms of Action;molecular modeling;multicatalytic endopeptidase complex;Mutation;National Center for Advancing Translational Sciences;novel;nuclease;Online Systems;Pathway interactions;patient response;Patient Selection;Patients;Peptide Hydrolases;Pharmaceutical Preparations;Pharmacogenomics;Pharmacology;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;precision medicine;predicting response;predictive marker;prevent;protein kinase inhibitor;Proteolysis;proteostasis;proteotoxicity;public database;Publishing;Rationalization;Recombinants;recombinational repair;recruit;Regulation;repaired;Replication Licensing;replication stress;Research;Resistance;Resources;response;RNA;Sarcoma;Site;small cell lung carcinoma;Stress;Structure;Sumoylation Pathway;targeted agent;targeted cancer therapy;temozolomide;Testing;Time;Tissues;tool;TOP1 gene;TOP2A gene;Topoisomerase;Topoisomerase Inhibitors;Tubulin;tumor;Tumor Suppressor Proteins;Tyrosine;tyrosyl-DNA phosphodiesterase;ubiquitin ligase;Ubiquitination;Virus Replication;web app;web site;Work;Zidovudine

PROJECT_TITLE: DNA Repair, Cell Cycle Checkpoints and Apoptosis as Targets for Anticancer Drugs


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Orphan Drug;Ovarian Cancer;Precision Medicine;Rare Diseases;Women's Health Research

PROJECT_TERMS: ABCB1 gene;ABCG2 gene;adduct;anti-cancer therapeutic;Antibody-drug conjugates;Antineoplastic Agents;Autoimmune Diseases;Binding;Biochemistry;Biological;Biological Markers;Biology;Blood;Bone Marrow;BRCA deficient;Camptothecin;cancer cell;Carbon Tetrachloride;Cardiotoxicity;Catenanes;Cell membrane;Cell Proliferation;Cells;Chemicals;chromatin remodeling;Chromosome Segregation;Clinic;Clinical;clinical center;clinical development;Clinical Oncology;Clinical Trials;cofactor;Collaborations;Colon Carcinoma;Complement;Complex;Cyclic Nucleotides;cytotoxic;Development;Diarrhea;DNA;DNA biosynthesis;DNA copy number;DNA Damage;DNA Double Strand Break;DNA Repair;DNA replication fork;DNA topoisomerase II alpha;DNA Topoisomerases;Dose Limiting;Doxorubicin;drug development;Drug Efflux;Embryo;endonuclease;Enzymes;Epirubicin;ERCC1 gene;Etoposide;Exatecan;Excision;Exhibits;fatty liver disease;FDA approved;Fibroblasts;Formulation;Genes;Genetic Transcription;Genome;Genomic Instability;Goals;Hematologic Neoplasms;homologous recombination deficiency;Human;Hybrids;hydroxyl group;Idarubicin;Immune;Immune System Diseases;inhibitor;insertion/deletion mutation;insight;Intercalating Agents;interest;irinotecan;Knockout Mice;Laboratories;Legal patent;Lesion;Licensing;Liver;Lung Carcinoma;macromolecule;Malignant Childhood Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;Membrane Transport Proteins;Metabolic stress;Mitochondria;Mitochondrial DNA;mitochondrial genome;Mitochondrial Proteins;Mitoxantrone;Molecular;mouse model;multicatalytic endopeptidase complex;Mus;Mutation;Natural regeneration;NCI Center for Cancer Research;Neurodegenerative Disorders;novel;Nuclear;nuclease;Nucleic Acids;Nucleotides;Obesity;Oncology;Organ;Ovarian Carcinoma;Pathway interactions;patient biomarkers;patient stratification;Patients;Peptide Hydrolases;Pharmaceutical Preparations;pharmacodynamic biomarker;Pharmacology;Pharmacology Study;Phase I Clinical Trials;Phase II Clinical Trials;phase II trial;Phenotype;Plant alkaloid;Poison;Post-Translational Protein Processing;precision medicine;prevent;Program Development;Property;Protein Biosynthesis;Publishing;Relaxation;repaired;Reporting;Resolution;response;Ribonucleotides;RNA;RNA Helicase;Rodent;Role;Site;SN-38;Structure;sugar;Sumoylation Pathway;synergism;therapeutic target;tissue regeneration;TOP1 gene;TOP2A gene;Topoisomerase;Topoisomerase II;Topoisomerase III;topoisomerase IIIalpha;Topoisomerase Inhibitors;Topotecan;Toxic effect;Toxin;transcriptome;Translations;tumor;tumor progression;Type I DNA Topoisomerases;tyrosyl-DNA phosphodiesterase;Universities;Vertebral column;Vertebrates;Water;Work

PROJECT_TITLE: DNA Topoisomerases as nuclear and mitochondrial targets of Anticancer Drugs


PI_NAMEs: BURKE, TERRENCE  (contact)

PROJECT_TERMS: Affinity;Aldehydes;Alkynes;Amines;Amino Acids;analog;anti-cancer;Antineoplastic Agents;Azides;Benzoic Acids;Binding;Biological;Biological Assay;Biology;biomaterial compatibility;Cancerous;Catalytic Domain;Cell Cycle Regulation;Cells;chemical stability;Chemicals;Chemistry;Collaborations;Colon Carcinoma;Colorectal Cancer;Complex;cost effective;covalent bond;Derivation procedure;design;Disulfides;DNA;DNA Repair Enzymes;DNA Topoisomerases;Docking;drug-like compound;Excision;Exhibits;Extracellular Domain;Family;flexibility;Fluorescein;Fluorescein-5-isothiocyanate;Fluorescence;Fluorides;G-Protein-Coupled Receptors;Home;inhibitor;inorganic phosphate;Investigation;kinase inhibitor;knock-down;Label;Laboratories;Left;Leucine-Rich Repeat;LGR5 gene;Libraries;Ligand Binding;Ligand Binding Domain;Ligands;Light;Malignant Neoplasms;Mediator;member;Methodology;mimetics;Molecular;Molecular Target;nanomolar;Nature;near infrared dye;Operative Surgical Procedures;Oximes;Parents;Peptide Synthesis;Peptides;peptidomimetics;pharmacologic;Phase;phosphodiester;Phosphotransferases;Phthalic Acids;PLK1 gene;PLK3 gene;Polo-Box Domain;polo-like kinase kinase 1;Positioning Attribute;Process;protein protein interaction;Proteins;quinoline;Quinolones;Reaction;Reagent;Recovery;Resources;Side;Signal Transduction;Site;small molecule;Solid;Stains;Structure;Sulfur;Synthesis Chemistry;System;Tissues;tool;Topoisomerase;Topoisomerase Inhibitors;Tyrosine;Tyrosine Kinase Inhibitor;tyrosyl-DNA phosphodiesterase;Variant;Work;wortmannin;X-Ray Crystallography

PROJECT_TITLE: Inhibitors of Tyrosine Kinase-Dependent Signaling as Anti-Cancer Agents


PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affinity;Amino Acids;anti-cancer research;Anti-HIV Agents;anti-viral efficacy;Binding;Binding Proteins;C-terminal;Caco-2 Cells;Chemicals;Chemistry;Chromatin;Clinical;Collaborations;Contracts;Coupling;Cryoelectron Microscopy;Data;design;Development;DNA;drug structure;Excision;Fasting;FDA approved;Formulation;Foundations;Free Energy;Future;Generations;Genes;Genetic Transcription;Goals;Histone H3.3;histone modification;Histones;HIV;HIV Integrase;HIV therapy;HIV-1;HIV-1 drug resistance;improved;inhibitor;Integrase;Integrase Inhibitors;Intestines;invention;Laboratories;Legal patent;lens epithelium-derived growth factor;Ligation;Liquid substance;Lysine;Macaca;Malignant Neoplasms;Methodology;Microscopy;Microsomes;Modification;mutant;Nanotechnology;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;novel;novel therapeutics;nucleoside analog;Nucleosomes;oxidation;Patients;Permeability;Plasma;Plasma Proteins;Polymers;Positioning Attribute;Process;Prodrugs;Program Development;programs;Proteins;Protocols documentation;PWWP Domain;Recommendation;Reporting;Resistance;resistance mechanism;resistance mutation;Resolution;Resources;Reverse Transcriptase Inhibitors;Salvage Therapy;Side;simulation;Solubility;Stomach;Structure;Testing;Thermodynamics;thioester;Variant;Virus;Work

PROJECT_TITLE: Design and Synthesis of HIV Integrase as Potential Anti-AIDS Drugs


PI_NAMEs: RANDAZZO, PAUL A (contact)

PROJECT_TERMS: Actins;ADP-Ribosylation Factors;Affect;Ankyrin Repeat;Area;Behavior;Binding;Biochemical;Biochemistry;Biology;Bundling;cancer cell;Catalysis;cell behavior;Cells;childhood sarcoma;Collaborations;Cytoskeleton;Defect;Dorsal;enzyme activity;F-Actin;Focal Adhesions;Goals;GTP Binding;GTP-Binding Proteins;GTPase-Activating Proteins;Guanosine Triphosphate;Hydrolysis;Invaded;Ligands;Link;Lipid Binding;Malignant Neoplasms;Mediating;member;Membrane;Microfilaments;migration;Modeling;Molecular;Molecular Conformation;Myoblasts;Neoplasm Metastasis;novel;Oncoproteins;Pathologic;PH Domain;Phosphatidylinositols;Prognosis;Proliferating;Proline;Property;Proteins;RAS Superfamily Proteins;Regulation;Resolution;Rhabdomyosarcoma;Role;SH3 Domains;Signal Pathway;Signal Transduction;Stress Fibers;Structure;Tertiary Protein Structure;Therapeutic;tumor progression;Work;Xenograft Model

PROJECT_TITLE: Regulation of ADP-ribosylation factor


NIH_SPENDING_CATS: Cancer;Genetics

PI_NAMEs: WICKNER, SUE H (contact)

PROJECT_TERMS: Adaptor Signaling Protein;Alzheimer's Disease;ATP-Dependent Proteases;Bacteria sigma factor KatF protein;Beryllium;Binding;Biological Models;C-terminal;cancer cell;cancer survival;cancer therapy;cell growth;Cellular Stress;Client;Collaborations;Combined Modality Therapy;Complex;Cystic Fibrosis;DNA biosynthesis;DNA-Directed RNA Polymerase;Drug Targeting;endopeptidase Clp;Escherichia coli;Eukaryota;Evolution;Exhibits;Fluorides;Goals;Growth;Homologous Gene;human disease;In Vitro;in vivo;inhibitor;Learning;Length;Malignant Neoplasms;Molecular Chaperones;Molecular Conformation;multicatalytic endopeptidase complex;nanomachine;Non-Insulin-Dependent Diabetes Mellitus;Nucleotides;Parkinson Disease;Pathway interactions;Peptide Hydrolases;Phase;Phosphorylation;Play;premature;prevent;Prion Diseases;protein aggregation;Protein Binding Domain;protein degradation;protein folding;Protein-Folding Disease;Proteins;Proteolysis;proteostasis;Reaction;Recovery;Regulation of Proteolysis;Research;response;Role;sigma-E factor;Signal Transduction;Stress;Structure;Surface;System;Tertiary Protein Structure;Testing;tumor;Universities;Work;Yeasts

PROJECT_TITLE: Molecular Chaperones and DNA Replication


PI_NAMEs: GOTTESMAN, SUSAN  (contact)

PROJECT_TERMS: Acetylation;Affect;Alleles;Antibiotics;Area;Bacteria;Bacteria sigma factor KatF protein;Behavior;Binding;biological adaptation to stress;Biological Assay;Bypass;capsule;cell behavior;Cell Communication;cell growth;Cell membrane;Cells;Collaborations;Complex;Development;Dissection;Distal;Equilibrium;Escherichia coli;Eukaryotic Cell;Evolution;Face;falls;Family;genetic regulatory protein;Genetic Screening;Goals;Growth;In Vitro;in vivo;insight;interest;Investigation;Klebsiella;Laboratories;Mediating;member;Membrane;Messenger RNA;Metabolism;Molecular Chaperones;mRNA Translation;mutant;Mutation;Names;National Institute of Child Health and Human Development;novel;Organism;pathogenic bacteria;Pathway interactions;Physiological;Play;Porifera;posttranscriptional;Process;Proteins;Quality Control;Regulation;Regulon;Reporter;Resistance;response;Ribonucleases;RNA;RNA Binding;RNA Stability;Role;screening;sensor;Series;Sigma Factor;Signal Transduction;Site;small molecule;Small RNA;Stress;symbiont;System;Time;tool;transcription factor;Translation Initiation;Untranslated RNA;Virulence Factors;Visit;Work

PROJECT_TITLE: Bacterial Functions Involved in Cell Growth Control


PI_NAMEs: ADHYA, SANKAR  (contact)

PROJECT_TERMS: Architecture;Binding;Binding Sites;Biochemical;Biological Models;Biological Process;biophysical techniques;cancer cell;Chromatin Loop;Chromosome Structures;Chromosomes;Cryoelectron Microscopy;developmental genetics;DNA;DNA-Directed RNA Polymerase;Elements;Engineering;Escherichia coli;Galactose;Gene Activation;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene repression;Genes;Genetic;genetic regulatory protein;Genetic Transcription;Geometry;Goals;Laboratories;mathematical methods;Microscopy;Molecular Biology;novel;Operon;Positioning Attribute;Prophages;Refractory;Regulation;Repression;Research;Shapes;System;Systems Biology;Testing;three dimensional structure;Transcriptional Regulation;transcriptome;Work

PROJECT_TITLE: Regulation of Gene Transcription


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Contraception/Reproduction;Genetics;Human Genome;Infertility;Women's Health Research

PI_NAMEs: CHENG, SHEUE-YANN  (contact)

PROJECT_TERMS: Abdomen;Address;aged;Anemia;Atrophic;Attention deficit hyperactivity disorder;Binding;Biological;bone;Bone Development;Clinical;Complex;Constipation;CRISPR/Cas technology;Development;digital;Disease;Dominant-Negative Mutation;Ectopic Expression;egg;Endometrial;Endometrium;Epithelium;Estrogen Receptors;Estrogens;Exhibits;Failure;Female;female fertility;Female infertility;Fertility;Fibrosis;Fishes;folliculogenesis;Functional disorder;Gene Expression Profiling;Gene Expression Regulation;Genes;genetic corepressor;Genitalia;Genomics;Gland;Growth;Health;hearing impairment;Heterozygote;Histologic;Homeostasis;hormone response element;Human;human disease;Hypertrophy;in vivo;Infertility;insight;keratinocyte differentiation;Laboratories;Lasers;Learning;Maintenance;Mammalian Oviducts;Mediating;Metabolic;Metaplasia;Metaplastic Cell;Modeling;Molecular;Morphogenesis;mouse model;Mus;Mutagenesis;mutant;Mutant Strains Mice;Mutate;Mutation;Nuclear;Nuclear Hormone Receptors;Obstruction;Ovarian;Ovary;Oviposition;Pathway Analysis;Patients;Premature Ovarian Failure;Protein Isoforms;recruit;Regulation;Reporting;Reproduction;reproductive;reproductive tract;Research;Resistance;Role;Serum;Sexual Maturation;Signal Pathway;Signal Transduction;Source;Squamous Metaplasia;Symptoms;T cell infiltration;THRA gene;THRB gene;Thyroid Gland;Thyroid Hormone Receptor;Thyroid hormone receptor alpha;Thyroid Hormone Receptor Gene;Thyroid Hormones;Thyrotropin;Tissues;tongue papilla;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Uterus;Wild Type Mouse;Zebrafish

PROJECT_TITLE: Thyroid Hormone Nuclear Receptors in Health and Disease


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: PASTAN, IRA  (contact)

PROJECT_TERMS: acute lymphoblastic leukemia cell;Acute Lymphocytic Leukemia;Agreement;B lymphoid malignancy;CCR;CD22 gene;Clinical;Clinical Protocols;Clinical Trials;Development;efficacy evaluation;Funding;Hairy Cell Leukemia;Hematopoietic Neoplasms;Human;IL2RA gene;Immunotoxin Therapy;Immunotoxins;Injections;LMB-2 Immunotoxin;Lymphoma;Malignant neoplasm of thorax;Malignant Neoplasms;Mus;Patients;Pharmacy facility;preclinical study;Regulatory T-Lymphocyte;Solid Neoplasm;subcutaneous;Supervision;Thoracic Oncology;tumor;Tumor Immunity

PROJECT_TITLE: Immunotoxin Therapy of Solid and Hematopoietic Tumors: Preclinical Studies


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Climate-Related Exposures and Conditions;Genetics;Human Genome;Skin Cancer

PI_NAMEs: MERLINO, GLENN T. (contact)

PROJECT_TERMS: Address;Adult;Animal Model;Architecture;Autophagocytosis;Behavior;BRAF gene;Cancer Biology;cancer genetics;Cancer Model;Cancer Patient;candidate identification;Catalogs;Cause of Death;CDKN2A gene;Cell Line;Cells;Childhood;Clinic;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Complex;Cutaneous Melanoma;Data;Databases;deep sequencing;design;Development;diagnostic biomarker;Disease;Distant;DNA Sequence Alteration;Dose;Drug resistance;Drug Targeting;drug testing;Ectopic Expression;Embryo;Endoplasmic Reticulum Degradation Pathway;endoplasmic reticulum stress;Etiology;Excision;exome sequencing;Exposure to;Expression Profiling;falls;Fishes;Fluorescence-Activated Cell Sorting;Gene Expression;Gene Expression Profiling;Genes;Genetic;Genetic Engineering;Genetically Engineered Mouse;Genomics;glycosylation;GNAQ gene;Goals;Green Fluorescent Proteins;Growth;Health Hazards;HGF gene;Human;human cancer mouse model;human disease;IGF1R gene;Immune checkpoint inhibitor;Immune mediated destruction;Immunocompetent;Immunotherapy;Impairment;in vivo;Incidence;Inflammatory;Influentials;inhibitor;Injections;insight;interest;Interferon alpha;Interferon Type II;irradiation;KAI1 gene;knock-down;Knock-out;Label;Laboratories;Lesion;Ligands;Link;Macrophage;malignant melanocyte;Malignant Neoplasms;malignant state;MCL1 gene;Mediating;Melanins;melanoblast;melanocyte;Melanocytic Neoplasm;Melanoma;Melanoma Cell;Melanoma patient;member;Metastatic malignant neoplasm to brain;Metastatic Melanoma;Metastatic Neoplasm to the Central Nervous System;MicroRNAs;mitochondrial metabolism;Modeling;Molecular;Molecular Analysis;mouse model;Mus;Mutagenesis;mutant;Mutation;Nature;Neonatal;Neoplasm Metastasis;neurodevelopment;Nevus;new therapeutic target;next generation;NF1 gene;novel;novel diagnostics;Oncogenes;Oncogenic;Organ;oxidative DNA damage;Pathway interactions;Patients;Pattern;Peptide Initiation Factors;Pharmaceutical Preparations;Phenotype;Phosphoric Monoester Hydrolases;Pigments;Play;pre-clinical;preclinical study;prevent;Primary Neoplasm;Process;programs;Proliferating;promoter;Proto-Oncogene Proteins c-akt;PTEN gene;Radiation;Radiation induced damage;Radiation therapy;Receptor Protein-Tyrosine Kinases;Receptor Signaling;recruit;Recurrence;Recurrent disease;Reporting;Research;Resistance;Resources;Retinoblastoma Protein;Risk;Risk Factors;RNA Interference;Role;Signal Pathway;Signal Transduction;Site;Skin;Sorting;Source;success;Sunburn;Sunscreening Agents;Tail;Testing;Tetracyclines;The Cancer Genome Atlas;Therapeutic;therapeutic target;Time;Tissues;tool;TP53 gene;transcriptome sequencing;transcriptomics;Transgenic Mice;Transplantation;tumor;tumor initiation;Ultraviolet B Radiation;Ultraviolet Rays;UV induced;UV Radiation Exposure;UVB induced;Uveal Melanoma;Veins;Zebrafish

PROJECT_TITLE: Genetically Engineered Mouse Models to Study Melanoma Genesis and Progression


PI_NAMEs: FITZGERALD, DAVID  (contact)

PROJECT_TERMS: Affinity;Algorithms;Antibodies;Antibody Therapy;Antibody-drug conjugates;Apoptosis;Bacteria;Bacterial Toxins;BCL-2 Protein;Binding;Binding Sites;Biological Response Modifier Therapy;cancer cell;Cancer cell line;cancer therapy;CCR;cell killing;Cell Line;Cells;chemical synthesis;chemotherapy;chimeric antigen receptor T cells;Clinic;Collaborations;Collection;Complement;cytotoxic;Cytotoxic agent;density;design;Development;dimer;Disulfides;Drug resistance;Drug Screening;Effectiveness;Enzymes;Epidermal Growth Factor Receptor;Exhibits;experimental study;Extracellular Domain;Fab Immunoglobulins;gene product;Genes;Germ Lines;Glioblastoma;Goals;Head and Neck Cancer;Human;Human Cell Line;humanized antibody;Hybridomas;Immunize;Immunotoxins;inhibitor;Investigation;KDR gene;lead candidate;Light;Link;Malignant Neoplasms;Mammalian Cell;Masks;Microtubules;Molecular Weight;Monoclonal Antibodies;Mus;mutant;Mutate;Nature;Neck Cancer;Non-Small-Cell Lung Carcinoma;Normal Cell;Normal tissue morphology;overexpression;Peptides;Pharmaceutical Preparations;Poison;pre-clinical;preclinical development;programs;receptor;Resistance;RNA Interference;screening;Site;Surface;targeted agent;targeted treatment;therapy development;three dimensional structure;Topoisomerase Inhibitors;Toxin;triple-negative invasive breast carcinoma;tumor;whole genome;Xenograft procedure

PROJECT_TITLE: Bio-Therapies for the Treatment of Cancer


PI_NAMEs: LOWY, DOUGLAS R. (contact)

PROJECT_TERMS: Binding;cancer therapy;Cell membrane;Cytoplasm;DLEC1 gene;EZH2 gene;Gene Expression;Goals;Growth;Guanosine Triphosphate;Hydrolysis;In Vitro;in vivo;Intervention;KRAS2 gene;Malignant Neoplasms;Mediating;MEKs;Neoplasms;Nuclear Export;Nuclear Protein;Oncogenes;Oncogenic;Pathogenesis;PI3K/AKT;prevent;protein complex;Protein Export Pathway;Ras Inhibitor;Regulation;Research;Signal Transduction;tumor;Tumor Suppressor Genes;Tumor Suppressor Proteins

PROJECT_TITLE: Tumor gene expression in vitro and in vivo


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Eye Disease and Disorders of Vision;HPV and/or Cervical Cancer Vaccines;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Sexually Transmitted Infections;Urologic Diseases;Vaccine Related

PI_NAMEs: SCHILLER, JOHN T. (contact)

PROJECT_TERMS: Adjuvant;Animal Model;Antigen Targeting;Auras;Basement membrane;Basic Science;Biological Response Modifier Therapy;Breast;cancer cell;cancer therapy;cancer type;Capsid;CCR;CD8B1 gene;Cell Culture Techniques;Cell surface;Clinical Trials;Collaborations;Communicable Diseases;companion animal;comparative;Costa Rican;Cytomegalovirus Vaccines;delivery vehicle;Disease;Dose;Drug Targeting;efficacy evaluation;efficacy trial;Epitopes;gene transfer vector;genetic vaccine;Glioblastoma;Human papilloma virus infection;Human Papilloma Virus Vaccine;Human Papillomavirus;Industry Collaboration;Infection;Injections;Intervention;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Modeling;Mus;Ocular Melanoma;Oncology;Papillomavirus;Pathway interactions;Peptides;Pharmaceutical Preparations;phase 3 study;phase I trial;pre-clinical;prevent;Proteins;Proteoglycan;recruit;Solid Neoplasm;T cell response;T-Lymphocyte;treatment strategy;Tropism;tumor;vaccine evaluation;Vaccines;Viral;Viral Vaccines;Virion;Virus Diseases

PROJECT_TITLE: Understanding Papillomavirus Virion Proteins and Vaccines


NIH_SPENDING_CATS: Cancer

PI_NAMEs: SINGER, ALFRED  (contact)

PROJECT_TERMS: Appearance;autoreactive T cell;autoreactivity;CD8-Positive T-Lymphocytes;CD8B1 gene;Clonal Deletion;Development;Down-Regulation;Event;GFI1 gene;Mature T-Lymphocyte;Mus;premature;Reporting;Self Tolerance;Signal Transduction;Sphingosine-1-Phosphate Receptor;T cell differentiation;T-Cell Receptor;T-Lymphocyte;thymocyte;Thymus Gland;Transcription Repressor

PROJECT_TITLE: T Cell Differentiation and Repertoire Selection


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Genetics;Immunotherapy;Women's Health Research

PI_NAMEs: YOUNG, HOWARD  (contact)

PROJECT_TERMS: Appearance;Architecture;Autoimmune Diseases;Autoimmunity;B-Lymphocytes;Belief;CD8-Positive T-Lymphocytes;Chronic;Communicable Diseases;cytokine;Development;Effector Cell;Exhibits;Female;female reproductive tract;Functional disorder;Gene Expression;Gene Modified;Genetic;Goals;Homeostasis;Immune;Immune response;Immune system;Immunity;Immunotherapeutic agent;Infection;Infertility;Infiltration;Inflammation;insight;Interferon Type II;Knockout Mice;Laboratories;Liver;Long-Term Effects;lymph nodes;male;Malignant Neoplasms;Memory;Modeling;mouse model;mRNA Stability;Mus;novel;Ovary;Physiological;Physiology;Pituitary Gland;Prolactin;reproductive;reproductive system disorder;response;Role;Sex Differences;Spleen;Systems Biology;T-Lymphocyte;Thymus Gland;Uterus;Work

PROJECT_TITLE: Consequences of chronic Interferon-gamma expression on the host


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Hematology;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: DURUM, SCOTT  (contact)

PROJECT_TERMS: Acute Lymphocytic Leukemia;Antibodies;Asthma;Autoimmune Diseases;Cell Proliferation;Cell Survival;cytokine;Dermatitis;Diabetes Mellitus;Disease;gain of function mutation;Goals;Health;IL7 gene;immunodeficiency;Interleukin 7 Receptor;Legal patent;leukemia;Licensing;Lymphoblastic Leukemia;Malignant Childhood Neoplasm;Methods;Monoclonal Antibodies;Multi-Institutional Clinical Trial;Multiple Sclerosis;Mus;Pathway interactions;patient derived xenograft model;relapse patients;Sepsis;Stem cell transplant;T-Cell Development;Therapeutic;United States National Institutes of Health

PROJECT_TITLE: Cytokines and T Cell Development


NIH_SPENDING_CATS: Breast Cancer;Cancer;Coronaviruses;Genetics;Women's Health Research

PI_NAMEs: WEISSMAN, ALLAN M (contact)

PROJECT_TERMS: 26S proteasome;African American Women;Alleles;Apoptosis;Binding;Binding Proteins;cancer therapy;CCR;Cell Death;cell motility;Cell Physiology;Cellular Stress;cellular targeting;Cholesterol;Complex;COVID-19 pandemic;Cues;Data;design;Deubiquitinating Enzyme;Endoplasmic Reticulum;Endoplasmic Reticulum Degradation Pathway;endoplasmic reticulum stress;Enzymes;fatty acid biosynthesis;Federal Government;Genetic;Goals;Golgi Apparatus;Growth;Human;Insulin;Integral Membrane Protein;interest;KAI1 gene;knock-down;Knowledge;Laboratories;Malignant Breast Neoplasm;Malignant Neoplasms;Mammals;MAPK8 gene;Mediating;Membrane;Membrane Fusion;Membrane Proteins;Metabolic;Mitochondria;Mitochondrial Matrix;Mitochondrial Proteins;mouse model;Multiple Myeloma;Mus;Neoplasm Metastasis;novel;Orthologous Gene;Outcome;Outer Mitochondrial Membrane;Pathway interactions;Peptide Hydrolases;Phosphorylation;Play;Predictive Factor;Process;protein degradation;Proteins;Publishing;Quality Control;Race;recruit;Response Elements;Ring Finger Domain;Risk Factors;Role;Sarcoma;SARS-CoV-2 protease;Scientist;Services;Site;Sterols;System;Temperature;Therapeutic;tumor;tumor autocrine motility factor receptor;UBE2G2 gene;Ubiquitin;ubiquitin isopeptidase;ubiquitin ligase;United States National Institutes of Health;Viral;Viral Physiology;Viral Proteins;Virus Activation;Woman;Work;Xenograft procedure;Yeasts

PROJECT_TITLE: Determining the Fate of Transmembrane Proteins


NIH_SPENDING_CATS: Cancer;Immunotherapy

PI_NAMEs: ROCHE, PAUL  (contact)

PROJECT_TERMS: Antigen Presentation Pathway;antigen processing;Antigen-Presenting Cells;Antigens;B-Lymphocytes;Binding;Binding Sites;Biology;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell membrane;Cellular biology;Cross Presentation;Dissociation;Endocytosis;Endosomes;Epitopes;Event;Goals;Histocompatibility Antigens Class I;Histocompatibility Antigens Class II;immune function;Immunological Models;invariant chain;Kinetics;Maps;MHC Class I Genes;MHC Class II Genes;Microscopy;Molecular;Molecular Chaperones;Movement;Mus;Pathway interactions;Peptides;Process;Proteins;Recycling;Regulation;Reporting;Resolution;Role;Route;Signal Transduction;T-Cell Activation;TNF Receptor-Associated Factors;TNFRSF5 gene;trafficking;trans-Golgi Network;ubiquitin-protein ligase;Ubiquitination

PROJECT_TITLE: Regulation of MHC Class II Trafficking in Antigen Presenting Cells


NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PI_NAMEs: KELLER, JONATHAN R (contact)

PROJECT_TERMS: Apoptosis;Binding;Binding Proteins;Blood Cells;cell growth;cell growth regulation;Cell Line;Cell Lineage;Cell Transplantation;Cells;comparison control;Cytarabine;Developmental Process;DNA;Enzymes;Event;Gene Expression;Genes;Genetic Transcription;Goals;Hematopoiesis;Hematopoietic stem cells;Histones;Human;ID2 gene;in vivo;leukemia;leukemia/lymphoma;MB02;Mediator;Membrane;Mitochondria;Molecular;mouse model;Mus;Mutate;myeloid cell development;Myeloid Cells;Patients;Play;Predisposition;Process;programs;Proteins;Reactive Oxygen Species;recruit;Role;self-renewal;senescence;Signal Transduction;Specific qualifier value;stem cell biology;stem cells;therapeutic target;transcription factor;Transplantation

PROJECT_TITLE: Molecular-Cellular Regulation of Hematopoietic Stem Cells


NIH_SPENDING_CATS: Cancer;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

PI_NAMEs: DAAR, IRA  (contact)

PROJECT_TERMS: Actins;Adaptor Signaling Protein;Adhesions;Affect;angiogenesis;Antigen-Antibody Complex;Apical;Axon;Benign;Binding;Biochemistry;Biological Models;Breast;Cancer cell line;Cell Adhesion;Cell Cycle Progression;cell fixing;Cell Line;cell motility;Cell Shape;Cell-Cell Adhesion;Cell-Matrix Junction;Cells;cellular imaging;Colon;Complex;Congenital Abnormality;constriction;Cues;Cytoplasmic Tail;Development;driving force;Dsh protein;Embryo;Embryonic Development;embryonic stem cell;Eph Family Receptors;Ephrins;epithelial to mesenchymal transition;Event;experimental study;Fibroblast Growth Factor;Fibroblast Growth Factor Receptors;Frequencies;gain of function;hindbrain;Human;Human Cell Line;human disease;in vivo;insight;Invaded;Laboratories;Ligand Binding;Ligands;Link;loss of function;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Melanoma;member;Membrane;migration;Modification;Morphogenesis;Movement;mutant;Myosin ATPase;Neoplasm Metastasis;neoplastic cell;Neural Crest Cell;Neural tube;Neural Tube Closure;Neuroblastoma;overexpression;Pathway interactions;Pattern;Phenotype;Play;pluripotency;Positioning Attribute;Proliferating;Prostate;Proteins;receptor;Receptor Protein-Tyrosine Kinases;recruit;Regulation;Repression;Research;Retina;retinal progenitor cell;Rho-associated kinase;Robinow syndrome;Role;scaffold;Scaffolding Protein;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Signaling Molecule;skeletal;small cell lung carcinoma;Stem Cell Development;stem cell fate specification;stem cells;System;Tissues;tumor;Tumor Angiogenesis;Tumor Cell Invasion;Tumor Cell Line;Tumor Stem Cells;tumorigenesis;Vertebrates;Visual Fields;WNT Signaling Pathway;Xenopus

PROJECT_TITLE: Mechanisms of Cross-talk Between EphrinB and Alternate Signaling Pathways


PI_NAMEs: MOCK, BEVERLY  (contact)

PROJECT_TERMS: Alleles;Amino Acids;Antibody Formation;B-Cell Activation;B-Cell Development;B-Lymphocytes;Biological Models;Body Size;Body Weight decreased;Bone Marrow;Burkitt Lymphoma;Cancer Model;Cell Cycle;cell growth;Cell Line;Cell Lineage;Cell Size;Cells;chemokine;Cloning;Code;Complex Genetic Trait;CRISPR/Cas technology;cytokine;Defect;Development;DNA;Embryo;Event;Exhibits;FOXP3 gene;Genes;Genetic Predisposition to Disease;Genetic Transcription;genetic variant;Genetically Engineered Mouse;Hematopoietic Neoplasms;Homeostasis;Homing;Human;Immune;in vivo;inhibitor;Knock-in;Knock-in Mouse;Knock-out;Laboratories;Lymphoma;Malignant Neoplasms;Mantle Cell Lymphoma;Memory;migration;Modeling;Modification;Multiple Myeloma;Mus;mutant;neutrophil;novel;Nucleic Acid Regulatory Sequences;Organ Size;Phenotype;Phosphorylation;Phosphotransferases;physiologic model;Plasma Cell Neoplasm;Plasmacytoma;Population;Predisposition;Process;Proliferating;Proto-Oncogene Proteins c-akt;Resistance;response;Role;Series;Signal Transduction;Sirolimus;Spleen;Susceptibility Gene;Susceptibility/Resistance Gene;T-Cell Proliferation;T-Lymphocyte;tumor

PROJECT_TITLE: The Genetics of Susceptibility to Mouse Plasma Cell Tumors


NIH_SPENDING_CATS: Cancer;Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: ANDERSON, STEPHEN K (contact)

PROJECT_TERMS: Binding Sites;Bone Marrow Transplantation;Cell Differentiation process;Cell Physiology;Cell-Mediated Cytolysis;Cells;CRISPR/Cas technology;Data;Development;Elements;Family;Future;GATA1 gene;GEM gene;Gene Expression;Genes;Genetic Polymorphism;Genetic Variation;Goals;hematopoietic stem cell differentiation;HLA-C Antigens;Human;Interleukin-15;Introns;Investigation;KLRD1 gene;Ligands;Major Histocompatibility Complex;man;Molecular;Mus;Natural Killer Cells;novel;Phenotype;Population;programs;promoter;receptor;Receptor Cell;receptor expression;Regulation;Research;Role;T-Cell Receptor;Transcript;transcription factor;trophoblast;tumor;Virus;Work

PROJECT_TITLE: Molecular Studies of Cellular Cytotoxicity


NIH_SPENDING_CATS: Cancer;Genetics;Pediatric

PI_NAMEs: MUEGGE, KATHRIN  (contact)

PROJECT_TERMS: 3-Dimensional;Affect;ATP phosphohydrolase;B-Lymphocytes;Cell Differentiation process;Cells;Childhood;Chromatin;Chromatin Loop;chromatin remodeling;Chromatin Structure;conditional knockout;Defect;DNA;DNA Double Strand Break;Embryonic Development;Enzymes;Epigenetic Process;Failure;Generations;Genetic Recombination;HELLS gene;Human;IgE;IgG1;IgG2;IgG3;Immune;Immune system;Immunocompetent;immunodeficiency;immunodeficiency-centromeric instability-facial anomalies syndrome;Immunoglobulin A;Immunoglobulin Class Switching;Immunoglobulin Switch Recombination;Immunoglobulins;Impairment;Knock-out;Knockout Mice;Lymphoid;Mediating;Molecular;Mutation;Organ;Patients;Play;precursor cell;Process;Production;Regulation;Role;Symptoms;Syndrome;Work

PROJECT_TITLE: Epigenetic control during embryogenesis


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Coronaviruses;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Rare Diseases;Vaccine Related

PI_NAMEs: ADHYA, SANKAR  (contact)

PROJECT_TERMS: 2019-nCoV;Bacterial Infections;Bacteriophages;Biotechnology;cancer cell;Collaborations;Communicable Diseases;COVID-19;developmental genetics;Diagnosis;Disease;Drug resistance;epidermal growth factor receptor VIII;Glioblastoma;human disease;Malignant Neoplasms;mouse model;Mus;nanobodies;Neutralization Tests;Phage Display;prevent;Publishing;Technology;Testing;Vaccines

PROJECT_TITLE: Use of Bacteriophages to Prevent, Diagnose, and Treat Diseases


PI_NAMEs: HAGER, GORDON L (contact)

PROJECT_TERMS: Acute;Adrenal Cortex Hormones;Affect;Agonist;antagonist;Binding;Biochemical;Biophysics;Cell Nucleus;Cells;Chromatin;Crystallography;Cues;Development;Disease Progression;DNA;DNA Binding;DNA receptor;Endocrine system;Environment;fluorescence imaging;Gene Expression;Genes;Genetic Transcription;Glucocorticoid Receptor;hormonal signals;hormone response element;Human;Imaging Techniques;Ligand Binding;Ligands;live cell imaging;Mediating;Mediator;Methods;Mineralocorticoid Receptor;Modeling;Nuclear Hormone Receptors;Nuclear Receptors;Nucleoplasm;Population;programs;receptor;receptor function;Regulatory Element;Repression;Signal Transduction;steroid hormone;Steroid Receptors;Structure;System;Time;Transactivation;transcription factor;transmission process

PROJECT_TITLE: Function of Steroid Receptors in Subcellular Compartments


NIH_SPENDING_CATS: Breast Cancer;Cancer;Natural Products;Women's Health Research

PI_NAMEs: AMBUDKAR, SURESH  (contact)

PROJECT_TERMS: ABCB1 gene;ABCC1 gene;ABCG2 gene;Adenine;Adenosine A3 Receptor;Affect;Affinity;Agonist;Antineoplastic Agents;Area;ATP phosphohydrolase;ATP-Binding Cassette Transporters;Baculovirus Expression System;Baculoviruses;Binding;Binding Sites;Biochemical;Biological Assay;Biological Availability;cancer cell;cancer drug resistance;Cancer Etiology;Cancer Patient;cancer therapy;Carrier Proteins;CCR;Cell surface;Cells;Chemicals;Chemoresistance;Chemotherapy-Oncologic Procedure;Chronic Disease;chronic pain;Clinical;Clinical Trials;Collaborations;Complement;Cryoelectron Microscopy;Data;design;Development;Docking;Dose;Drug Efflux;Drug Interactions;Drug Kinetics;drug repurposing;Drug resistance;Drug Transport;drug-sensitive;Exhibits;FDA approved;flexibility;Goals;Hela Cells;Homidium Bromide;Human;improved;in silico;inhibitor;innovation;Insecta;interdisciplinary approach;Ligands;Light;Link;Location;luminescence;Maryland;MDA MB 231;Mediating;Membrane;Mitochondria;Molecular;Molecular Conformation;molecular dynamics;molecular modeling;Multi-Drug Resistance;multidrug resistant cancer;Mutagenesis;mutant;Mutation;Mutation Analysis;Names;National Institute of Diabetes and Digestive and Kidney Diseases;Natural Products;novel therapeutic intervention;Nucleosides;Orphan;overexpression;Pharmaceutical Preparations;Photochemistry;Photosensitizing Agents;Play;prevent;Primary carcinoma of the liver cells;Production;programs;Property;Psoriasis;PUVA Photochemotherapy;Regulation;Resistance;Resolution;Rheumatoid Arthritis;Rhodamine 123;risk mitigation;Role;screening;Series;simulation;Site;small molecule;small molecule libraries;Structure;Substrate Specificity;success;Suppressor Mutations;systemic toxicity;Tariquidar;Testing;Therapeutic;thermostability;Time;triple-negative invasive breast carcinoma;Tyrosine Kinase Inhibitor;United States National Institutes of Health;Universities;uptake;Vinblastine;Work;Xenobiotics

PROJECT_TITLE: Biochemical Analysis of Multidrug Resistance-linked Transport Proteins


NIH_SPENDING_CATS: Ataxia Telangiectasia;Cancer;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Neurodegenerative;Pediatric;Pediatric Cancer;Primary Immunodeficiencies;Radiation Oncology;Rare Diseases

PI_NAMEs: NUSSENZWEIG, ANDRE A. (contact)

PROJECT_TERMS: Achievement;Affect;Animals;Antigen Receptors;Area;Ataxia Telangiectasia;B-Cell Lymphomas;Burkitt Lymphoma;Cell Proliferation;cell type;Cells;Chimeric Proteins;Chromatin Structure;Chromosomal Instability;Chromosomal translocation;Chromosomes;Common Neoplasm;Complex;Defect;Detection;Development;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA lesion;DNA Repair;Double Strand Break Repair;Future;Gene Amplification;Genetic Recombination;Genome Stability;Genomic Instability;Germ Cells;Goals;Hematopoietic Neoplasms;Hereditary Disease;Human;immunodeficiency;Karyotype;Knock-out;Knockout Mice;Lymphocyte;Maintenance;Malignant lymphoid neoplasm;Malignant Neoplasms;Mammalian Cell;Meiotic Recombination;Monitor;mouse model;Mus;Nijmegen Breakage Syndrome;Nonhomologous DNA End Joining;Oncogenes;Oncogenic;Pathway interactions;Physiological;Predisposition;Premature aging syndrome;Proteins;Radiation Tolerance;Reaction;Reciprocal Translocation;repaired;Research;response;Signal Transduction;Solid Neoplasm;System;TP53 Gene Inactivation;Transgenic Mice

PROJECT_TITLE: DNA repair


NIH_SPENDING_CATS: Biotechnology;Cancer

PROJECT_TERMS: Affinity;Antibodies;Area;Back;Binding;Binding Sites;Botulinum Toxins;C-terminal;CCR;Clinical;Deubiquitinating Enzyme;Disease;Dissociation;Endoplasmic Reticulum;Enzymes;Family member;Federal Government;Goals;Heterogeneity;Iatrogenesis;insight;interest;Intoxication;Light;Longevity;Malignant Neoplasms;Membrane;Modality;Molecular;Mutation;Neurotoxins;novel;Play;Poisoning;Protac;protein function;Proteins;Publishing;recruit;response;Ring Finger Domain;Role;Scientist;Serotyping;Services;Site;small molecule;Structure;Structure-Activity Relationship;Substrate Interaction;System;Targeted Toxins;Therapeutic;Toxin;TRAF2 gene;Transfection;UBE2G2 gene;Ubiquitin;ubiquitin isopeptidase;ubiquitin ligase;Ubiquitin-Activating Enzymes;Ubiquitin-Conjugating Enzymes;ubiquitin-protein ligase;Ubiquitination;United States National Institutes of Health;Woman;Work;Yeasts

PROJECT_TITLE: Enzymes and Substrates of the Ubiquitin Conjugating System


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Genetics;Immunotherapy;Liver Disease;Nutrition

PI_NAMEs: MCVICAR, DANIEL W. (contact)

PROJECT_TERMS: Aconitic Acid;Animal Model;Animals;Area;Biochemical Pathway;Biological Assay;Biology;cancer therapy;Carbon;Carboxy-Lyases;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Physiology;cell type;Cells;Cellular Metabolic Process;Coenzyme A;Colitis;Colon;Complex;Development;Disadvantaged;Disease;Dissection;engineered T cells;Environment;Enzymatic Biochemistry;Enzymes;experimental study;feeding;Fermentation;Foundations;Generations;Genes;Genetic Transcription;Glucose;glucose tolerance;Glycolysis;Goals;Hepatocyte;High Fat Diet;Host Defense Mechanism;Human;Immune;immune modulating agents;Immune response;Immunologics;Immunosuppression;In Vitro;in vivo;Inflammation;Inflammatory;inhibitor;Insulin Resistance;interest;Investigation;Knockout Mice;Label;Leukocytes;lipid metabolism;Lipids;Liver;Macrophage;Maintenance;Malignant Neoplasms;Mediating;Metabolic;Metabolic Diseases;Metabolic Pathway;metabolomics;Mitochondria;Molecular Biology;Mus;Muscle;Natural Killer Cells;Nature;neoplastic cell;nonalcoholic steatohepatitis;Nutritional Requirements;Obesity;oxidation;Oxidation-Reduction;Oxidative Phosphorylation;Palmitates;Pathogenicity;Patients;Phenotype;Phosphoenolpyruvate;Phosphorylation;Physiological;Physiology;Play;Predisposition;Production;programs;Proliferating;Protein Isoforms;Proteins;Pyruvate;Pyruvate Kinase;Pyruvate Metabolism Pathway;Regulation;Resources;Role;Source;System;T-Cell Proliferation;T-Lymphocyte;Therapeutic;therapeutic target;Time;transcription factor;tumor;Tumor Expansion;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-associated macrophages;Uncertainty;Vascularization;Work

PROJECT_TITLE: Immunometabolism in Cancer and Inflammation


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Human Genome;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

PI_NAMEs: KREITMAN, ROBERT  (contact)

PROJECT_TERMS: Aftercare;Agammaglobulinaemia tyrosine kinase;anaplastic thyroid cancer;anti-CD20;Anti-CD22;B lymphoid malignancy;B-Cell Leukemia;B-Lymphocytes;Biological Assay;Biology;Blood;BRAF gene;Cancer Therapy Evaluation Program;CD22 gene;CD22 Immunotoxin;cell bank;Cells;Chemoresistance;chemotherapy;chimeric antigen receptor T cells;Cladribine;Clinical;clinical development;Clinical Trials;Collaborations;Combination Drug Therapy;COVID-19 pandemic;cytotoxicity;Data Science;Development;Disease;Dose;Drug Combinations;Eligibility Determination;exome;exome sequencing;Exotoxins;experience;FDA approved;Follicular Lymphoma;follow-up;Foundations;genetic profiling;Goals;Hairy Cell Leukemia;hairy cell leukemia cell;Hematologic Neoplasms;high risk population;Histology;immunogenicity;Immunoglobulins;Immunotoxins;inhibitor;Laboratories;large cell Diffuse non-Hodgkin's lymphoma;leukemia/lymphoma;Leukemic Cell;Licensing;Life;Lymphoma;Malignant Neoplasms;Mantle Cell Lymphoma;Methods;Mitogen-Activated Protein Kinase Inhibitor;Mitogen-Activated Protein Kinases;Molecular;MS4A1 gene;Multicenter Trials;Mutation;Newly Diagnosed;next generation sequencing;Non-Hodgkin's Lymphoma;novel therapeutic intervention;Ohio;participant enrollment;Pathogenesis;Pathway interactions;Patients;Pentostatin;Pharmaceutical Preparations;Pharmacologic Substance;Phase;phase II trial;Population;Preparation;Prognosis;programs;Progression-Free Survivals;Proteins;Pseudomonas;Publishing;purine analog;randomized trial;Recombinants;Refractory;Regimen;Relapse;Reporting;Residual Neoplasm;response;Retreatment;rituximab;RNA;Sampling;single cell sequencing;small molecule;Solid Neoplasm;standard of care;targeted agent;targeted treatment;Testing;Time;Toxicity due to chemotherapy;Toxin;transcriptome;Treatment Efficacy;Treatment-related toxicity;Tumor Burden;Tumor Markers;Tyrosine Kinase Inhibitor;United States National Institutes of Health;Universities;Variant;Waldenstrom Macroglobulinemia;Work

PROJECT_TITLE: Development of Recombinant Toxins to Treat Hematologic Malignancies


PI_NAMEs: SAMELSON, LAWRENCE  (contact)

PROJECT_TERMS: Adaptor Signaling Protein;antigen binding;Antigens;Binding;Biochemical;Biophysics;Cell membrane;Cells;Cellular biology;chimeric antigen receptor;Complex;Coupled;Dissociation;Distal;Elements;Enzyme Activation;enzyme pathway;Enzymes;Genetic Techniques;Human;imaging study;Immune response;improved;In Vitro;in vivo;inorganic phosphate;Kinetics;Link;Lymphocyte;Lymphocyte-Specific p56LCK Tyrosine Protein Kinase;Malignant Neoplasms;Membrane;Microscopic;Microscopy;Molecular;molecular site;mouse model;neoplastic cell;Pathologic;Pathway interactions;Patients;Phosphorylation;Phosphotransferases;Process;Property;Protein Tyrosine Kinase;Proteins;Publishing;receptor;Receptor Protein-Tyrosine Kinases;recruit;Reporting;Signal Transduction;Signaling Molecule;Signaling Protein;Site;src-Family Kinases;Structure;study characteristics;superresolution microscopy;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Transmembrane Domain;tumor;Tyrosine;ultra high resolution;ZAP-70 Gene

PROJECT_TITLE: Biochemical Basis of T Cell Activation


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Racial and Ethnic Minority Health Research;Rare Diseases;Women's Health Research

PI_NAMEs: STERNECK, GISELA  (contact)

PROJECT_TERMS: Address;Area;Biological Assay;Biological Models;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Model;Breast Epithelial Cells;cancer cell;CCAAT-enhancer-binding protein-delta;Cell Adhesion;cell growth;Cell Line;cell transformation;Cell-Cell Adhesion;Cells;Cessation of life;Classification;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Cues;Development;Dinoprostone;Disseminated Malignant Neoplasm;E-Cadherin;Embolism;Event;Exhibits;Gene Expression;Genes;glycogen synthase kinase 3 beta;Goals;Hematopoiesis;Human;Hypoxia;immune function;Immune response;In Vitro;Inflammation;inflammatory breast cancer;insight;Invaded;Investigation;Knock-out;Knockout Mice;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary gland;Mammary Neoplasms;Mediating;Metabolic;Metastatic breast cancer;Modeling;Modification;Molecular;Molecular Target;mouse model;Mus;Myelogenous;Myeloid Progenitor Cells;Neoplasm Metastasis;neoplastic cell;neutrophil;novel therapeutic intervention;Pathway interactions;patient derived xenograft model;Phenotype;potential biomarker;Property;Proteins;PTGS2 gene;racial disparity;Rare Diseases;Regulation;Research;response;Role;Signal Pathway;Signal Transduction;Skin;socioeconomic disparity;Therapeutic;three dimensional cell culture;Tissues;transcription factor;Transgenic Organisms;tumor;tumor microenvironment;tumor progression;Tumor Promotion;tumorigenic;United States National Institutes of Health;Work

PROJECT_TITLE: Molecular Mechanisms Regulating Mouse Mammary Gland and Human Breast Tumor Cells


PROJECT_TERMS: Affect;Agonist;Androgens;antagonist;Biological;Biological Assay;Biosensor;cell fixation;Cell Line;Cell Nucleus;Cells;chemical association;Chimera organism;Cytoplasm;Detection;Endocrine Disruptors;Endocrine system;Environment;Environmental Exposure;Estrogens;Exposure to;Glucocorticoid Receptor;Glucocorticoids;Gonadal Steroid Hormones;Green Fluorescent Proteins;Health;Health Hazards;Hormones;Human;human disease;in vivo imaging;Label;Ligand Binding Domain;Ligands;Methods;mimetics;Natural Compound;NF1 gene;novel;Nuclear;Nuclear Receptors;Organism;Penetration;Prevalence Study;Progesterone Receptors;Progestins;Protein Isoforms;receptor;receptor function;Reporting;response;Role;Sampling;screening;Soil;Stains;Steroids;Testing;Time;Water Pollutants;water sampling;Water Supply

PROJECT_TITLE: In vivo Imaging Analysis of Steroid-Nuclear Receptor Function


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Genetics;Human Genome;Rare Diseases

PI_NAMEs: MISTELI, THOMAS A (contact)

PROJECT_TERMS: Affect;Aging;Architecture;Biochemical;Biological;Biological Models;Cell Nucleus;Cells;Development;Disease;Genome;Genome Mappings;Goals;Health;Human;imaging approach;imaging modality;in vivo;Laboratories;Malignant Neoplasms;Maps;Methods;Molecular;Nuclear;Premature aging syndrome;Process;Progeria;Role;Sampling;screening;Syndrome;Tissues

PROJECT_TITLE: Nuclear Architecture and Disease


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Digestive Diseases - (Gallbladder);Genetics;Hepatitis;Human Genome;Immunotherapy;Liver Cancer;Liver Disease;Orphan Drug;Precision Medicine;Prevention;Rare Diseases

PI_NAMEs: WANG, XIN WEI  (contact)

PROJECT_TERMS: Acceleration;Area Under Curve;arm;Biliary Tract Cancer;Biological Markers;CA-19-9 Antigen;cancer cell;cancer clinical trial;cancer diagnosis;Cancer Etiology;Cancer Patient;Case/Control Studies;Cells;Cessation of life;Characteristics;chronic liver disease;Classification;clinical diagnosis;cohort;curative treatments;Data;Development;Diagnosis;diagnostic strategy;Disease;early detection biomarkers;Early Diagnosis;early onset;Epitopes;exome;exome sequencing;Exposure to;Failure;Formalin;human virome;Image;immune cell infiltrate;Immune checkpoint inhibitor;Immunity;Immunologic Surveillance;Immunoprecipitation;Immunotherapy;improved;improved outcome;Individual;interest;Intrahepatic Cholangiocarcinoma;Lesion;Libraries;liver function;Liver neoplasms;Longitudinal cohort;Longterm Follow-up;machine learning method;Malignant neoplasm of liver;Malignant Neoplasms;Methods;Modality;Molecular;mortality;National Cancer Institute;Neoplasm Circulating Cells;neoplastic cell;Outcome;Paraffin Embedding;Pathogenicity;patient screening;patient subsets;Patient-Focused Outcomes;Patients;Phage Display;Phage ImmunoPrecipitation Sequencing;Population Control;Populations at Risk;precision medicine;Primary carcinoma of the liver cells;Primary Malignant Neoplasm of Liver;Prospective Studies;Recording of previous events;Reporting;Research;response;Risk;Risk Factors;risk stratification;Sampling;screening;Sensitivity and Specificity;Serology;Serum;Site;specific biomarkers;Specimen;Subgroup;Surveillance Program;survival outcome;Time;Tissues;transcriptome;transcriptome sequencing;treatment response;tumor;Tumor Biology;Validation;Viral;Viral Antibodies;Viral hepatitis;Virus;Virus Diseases;virus host interaction;α-Fetoproteins

PROJECT_TITLE: Strategies for improving early detection, diagnosis and treatment of liver cancer


NIH_SPENDING_CATS: Cancer;Infectious Diseases

PI_NAMEs: XIA, DI S (contact)

PROJECT_TERMS: 3-Dimensional;Aconitate Hydratase;Active Biological Transport;Address;Agriculture;Anabolism;analog;anti-fungal agents;Antibiotics;Area;atovaquone;ATP Hydrolysis;ATP-Binding Cassette Transporters;Automobile Driving;Behavior;Binding;Biochemical;Bioenergetics;Biogenesis;Biological;Blood - brain barrier anatomy;Bos taurus;cancer therapy;Cattle;Cell Physiology;Cell surface;Cells;Cellular biology;Chemotherapy-Oncologic Procedure;Citric Acid Cycle;Clinic;clinical application;Coenzyme Q10;Complex;Core Assembly;Couples;Coupling;Cryoelectron Microscopy;Crystallography;Cytochrome bc1 Complex;cytochrome c;cytotoxicity;Data Set;design;Development;Drug resistance;Electron Transport Complex III;Elements;Energy Metabolism;Enzymes;Family;flexibility;Focus Groups;fungicide;Glycoproteins;Goals;Heavy Metals;Homologous Gene;Human;in silico;Individual;Infection;inhibitor;interest;Intervention;Ion Channel;Knowledge;knowledge integration;Laboratory Animals;Lead;Link;Lobe;Malate Dehydrogenase;Malignant Neoplasms;Medical;Membrane;Membrane Proteins;Membrane Transport Proteins;Methods;Methylation;microbial;Mitochondria;Mitochondrial Membrane Protein;Molecular;Molecular Conformation;Monoclonal Antibodies;Motion;Movement;Multi-Drug Resistance;Mus;mutant;Mutation;novel;Nucleotides;Organism;overexpression;oxidation;Oxidoreductase;Oxygen;pathogen;pathogenic microbe;Pathway interactions;Pharmaceutical Preparations;pharmacologic;photosynthetic bacteria;Pichia;Positioning Attribute;programs;Protein Conformation;Protein Dynamics;protein function;Proteins;Protons;receptor;Regulation;Research;Research Design;Resistance;Resolution;respiratory;Respiratory Chain;Rhodobacter sphaeroides;Role;Rotation;Series;Site;small molecule;small molecule libraries;Structure;Structure-Activity Relationship;Substrate Interaction;success;Succinates;Surface;targeted agent;Tariquidar;Testing;Therapeutic;Therapeutic Agents;therapeutic protein;Time;Transmembrane Domain;ubiquinol;Ubiquinone;Variant;virtual screening;Visualization;Work;Zebrafish

PROJECT_TITLE: Structural Basis of Biological Membrane Protein Functions and Drug Resistance


NIH_SPENDING_CATS: Cancer;Genetics;Infectious Diseases

PI_NAMEs: JI, XINHUA  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Amino Acids;Anti-Bacterial Agents;anti-cancer;Anti-HIV Agents;anti-microbial drug;antimicrobial;Basic Science;Binding;Biochemical;Biogenesis;Biological;Biological Assay;Biological Models;Biophysics;Catalysis;Cell division;cell growth;Complex;Couples;Data;design;Development;Dimerization;DNA-Directed RNA Polymerase;Double-Stranded RNA;Drug Design;drug development;endonuclease;Endoribonucleases;enzyme pathway;Eukaryota;Exhibits;Family;Folic Acid;Goals;Guanosine Triphosphate Phosphohydrolases;helicase;Hydrolysis;inhibitor;Ions;macromolecule;Magnesium;magnesium ion;Malignant Neoplasms;Mammals;Maps;member;microorganism;Modeling;Molecular Conformation;novel;Nucleotides;Orthologous Gene;phosphodiester;Play;Prokaryotic Cells;Proteins;Reaction;Recycling;Research;Ribonuclease III;Ribonucleases;RNA;RNA Interference;RNA metabolism;RNA Processing;Role;Side;Site;Site-Directed Mutagenesis;structural biology;Structure;System;targeted agent;therapeutic development;transcription factor;Virus Diseases;Yeasts

PROJECT_TITLE: Biomolecular Structure and Mechanism, Structure-Based Drug Design


NIH_SPENDING_CATS: Cancer

PI_NAMEs: MORRISON, DEBORAH  (contact)

PROJECT_TERMS: Affinity;anti-cancer research;Basic Science;Binding;Binding Proteins;Biochemical;Biological Assay;Bioluminescence;BRAF gene;cancer cell;cancer therapy;Cell membrane;Cell Survival;Cells;Cellular Stress;Clinical Research;Collaborations;Collection;Complex;computerized tools;Cryoelectron Microscopy;developmental disease;dimer;Dimerization;Disease;Disease Progression;Division of Cancer Epidemiology and Genetics;Down-Regulation;Drug resistance;Effectiveness;Embryo;Energy Transfer;Environment;Enzymes;Event;Exhibits;Extramural Activities;Family;Family member;Feedback;gain of function;Goals;Growth;Growth and Development function;Guanosine Triphosphate Phosphohydrolases;high resolution imaging;high-throughput drug screening;Human;human disease;inhibitor;kinase inhibitor;KRAS2 gene;Laboratories;Length;Link;Lipids;Malignant Neoplasms;Mammalian Cell;MAP Kinase Gene;Mass Spectrum Analysis;Mediating;MEKs;member;Methodology;Modeling;Molecular;Molecular Target;Monitor;monomer;Movement;mutant;Mutation;Natural Products;NCI Center for Cancer Research;Neoplasm Metastasis;novel;Pathway interactions;patient advocacy group;Pharmacotherapy;Phosphorylation;Positioning Attribute;Post-Translational Protein Processing;preference;programs;Proliferating;Protein Kinase;Proteins;raf Kinases;RAS genes;RAS inhibition;ras Proteins;Ras Signaling Pathway;Ras/Raf;Regulation;Reporting;Research;Research Personnel;Resolution;Role;Route;Severities;Signal Transduction;Signal Transduction Pathway;structural biology;Structure;System;targeted treatment;Techniques;Tertiary Protein Structure;Therapeutic;Therapeutic Intervention;Time;tool;tumor progression;tumorigenesis;Work;Zebrafish

PROJECT_TITLE: Regulation of Ras-Dependent Signal Transduction Pathways


PI_NAMEs: ACHARYA, JAIRAJ  (contact)

PROJECT_TERMS: Antineoplastic Agents;Apoptosis;base;Biological Process;Brain;cancer cell;cancer therapy;Cell Death;cell growth;Cells;ceramide 1-phosphate;ceramide kinase;Ceramides;Cessation of life;chemotherapy;Chemotherapy-Oncologic Procedure;Clinical;Development;diabetic;Dietary Fats;Disease;Drosophila genus;drug resistance development;Environment;Enzymes;Etiology;experimental study;Failure;Fat Body;Generations;Genetic;gut-brain axis;Hyperglycemia;Hyperlipidemia;in vivo;Inhibition of Apoptosis;Insulin;insulin secretion;insulin-like peptide;Investigation;Link;Lipase;Lipids;Lipoprotein (a);lipoprotein lipase;Malignant Neoplasms;Mediating;Metabolic Pathway;Metabolism;Midgut;Molecular;Multi-Drug Resistance;mutant;particle;Phospholipids;Physiological;Physiology;Process;Proliferating;Publishing;Regulation;Research;Research Personnel;response;Signal Transduction;Sphingolipids;Structure;success;therapeutically effective

PROJECT_TITLE: Phospholipid and Sphingolipid Signaling in Drosophila


PI_NAMEs: FELBER, BARBARA K (contact)

PROJECT_TERMS: Achievement;Acquired Immunodeficiency Syndrome;Address;Adjuvant;AIDS clinical trial group;Antibody Response;Antigens;Chronic;Clinic;clinical development;Clinical Trials;cohort;Collaborations;Combination immunotherapy;combinatorial;COVID-19;cytokine;Cytotoxic T-Lymphocytes;Data;Data Analyses;Development;Disease remission;DNA;DNA delivery;DNA Vaccines;Electroporation;Elements;Epitopes;Exclusion;Exhibits;expression vector;Formulation;frontier;Genes;Goals;Highly Active Antiretroviral Therapy;HIV;HIV Infections;HIV vaccine;HIV Vaccine Trials Network;HIV-1;Homologous Gene;Human;human disease;Immune checkpoint inhibitor;Immune response;Immunization;immunogenic;Immunologics;Immunotherapeutic agent;Immunotherapy;in vivo;Infection;insight;Interleukin-12;Length;lipid nanoparticle;Macaca;Mediating;Memory;Messenger RNA;Methodology;Methods;Modality;Modeling;Molecular;mRNA lipid nano particle vaccine;Mus;National Institute of Allergy and Infectious Disease;novel;novel strategies;novel vaccines;Nucleic Acid Vaccines;Participant;Pathway interactions;Persons;Phase;preclinical trial;prevent;Preventive vaccine;Process;Proteins;Proteome;Publications;Regimen;Research;response;RNA vaccine;Secondary Immunization;SIV;T cell response;T-Lymphocyte;Testing;therapeutic vaccine;tool;Translating;Translations;treatment strategy;vaccin protein;Vaccination;vaccine development;vaccine evaluation;vaccine platform;vaccine strategy;vaccine trial;Vaccines;Variant;Viral;Viral reservoir;Virus;Virus Diseases

PROJECT_TITLE: Conserved Element DNA Vaccine


NIH_SPENDING_CATS: Cancer;Genetics

PI_NAMEs: LEWANDOSKI, MARK B (contact)

PROJECT_TERMS: Affect;allantois;Apoptotic;Behavior;Biological;Biology;bone;cancer therapy;cardiogenesis;cell behavior;Cell Death;Cell Hypoxia;Cell Maintenance;Cell Survival;Cells;Collaborations;Communities;Complex;Computer Models;Congenital Abnormality;Defect;Dermis;Development;Disease;Embryo;Embryonic Development;external genitalia;Family;FGF17 gene;Fibroblast Growth Factor;fibroblast growth factor 18;Gene Expression;Generations;Genes;Genetic;genetic manipulation;Genetic Models;Genetic study;Genets;Goals;Growth Factor Gene;Health;HIF1A gene;Hindlimb;Human;Hypoxia;innovation;insight;Intermediate Mesoderm;Kidney;Knowledge;Ligands;Link;male;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;medical schools;Mesoderm;Messenger RNA;migration;Modeling;Molecular;Morphogenesis;mouse genetics;Mus;Muscle;mutant;nephrogenesis;notch protein;novel;Oxygen;Paper;Pathway interactions;Play;Positioning Attribute;Process;Proliferating;Publications;Publishing;reproductive tract;Role;Series;Signal Transduction;Somites;somitogenesis;spine bone structure;stem cells;Technology;Testicular Neoplasms;Tissues;tool;transcription factor;tumorigenesis;Undifferentiated;vertebra body;vertebrate embryos;WNT Signaling Pathway;Work

PROJECT_TITLE: The Role of Fgf Signaling in Vertebrate Development


NIH_SPENDING_CATS: Cancer;Genetics;Neurosciences;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

PI_NAMEs: YAMAGUCHI, TERENCE  (contact)

PROJECT_TERMS: 3-Dimensional;Adoption;Adult;adult stem cell;beta catenin;Binding;Brain;Cancer Etiology;cancer therapy;Cardiac;Cell Culture Techniques;Cell Reprogramming;Cells;ChIP-seq;Coupled;Data;Development;Developmental Process;DNA;DNA Binding;Embryo;Embryonic Development;embryonic stem cell;Enhancers;Environment;Epiblast;experimental study;Family;Fingers;gastrulation;Gene Expression;Gene Expression Profile;gene regulatory network;gene repression;Genes;Genetic Transcription;Germ Layers;Goals;Head;Heart;Homeobox;In Vitro;insight;Knowledge;Laboratories;Malignant Neoplasms;Manuscripts;member;Mesoderm;Methods;Modeling;Molecular;multiple omics;Mus;Muscle;Musculoskeletal;Mutation;Natural regeneration;nerve stem cell;neural;novel;overexpression;Pathway interactions;Pattern;Play;Pluripotent Stem Cells;Preparation;prevent;Primitive Streaks;progenitor;programs;promoter;recruit;Regenerative Medicine;Regulation;Repression;Reproducibility;response;Role;self renewing cell;self-renewal;Signal Pathway;Signal Transduction;Signaling Molecule;Somites;Spinal Cord;spinal cord regeneration;stem cell biology;Stem Cell Development;stem cell differentiation;stem cell homeostasis;stem cell self renewal;stem cells;Tail;TCF Transcription Factor;Time;Tissues;transcription factor;Transcription Repressor;transcriptome sequencing;tumorigenesis;vertebrate embryos;WNT Signaling Pathway;Work;Xenopus laevis;Zinc Fingers

PROJECT_TITLE: The Role of Wnt Genes in Vertebrate Development and Cancer


NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;Infectious Diseases;Prevention

PI_NAMEs: WLODAWER, ALEXANDER  (contact)

PROJECT_TERMS: 2019-nCoV;Acquired Immunodeficiency Syndrome;AIDS prevention;anti-cancer;Anti-HIV Agents;Anti-malarials;Antibodies;Area;Aspartic Endopeptidases;Binding;Binding Sites;C-terminal;Carbohydrates;CCAAT-Enhancer-Binding Proteins;Chimeric Proteins;Clinical;combat;Complex;COVID-19;Cryoelectron Microscopy;Crystallization;Crystallography;cytokine;Cytokine Receptors;design;dimer;Disaccharides;drug development;Drug resistance;E1A-associated p300 protein;endopeptidase La;Engineering;Enhancers;Enzymes;EP300 gene;Family;Family member;Feline Immunodeficiency Virus;Histones;HIV Infections;HIV Protease;HIV-1;Human;Human T-lymphotropic virus 1;inhibitor;insight;interest;Interferons;interleukin 20;Interleukin-10;interleukin-19;interleukin-22;Interleukin-24;Investigation;JAK1 gene;Lectin;leukemia;Ligands;Malignant Neoplasms;Mannose;member;method development;monomer;neutralizing antibody;Oligosaccharides;Pepsin A;Peptide Hydrolases;peptide structure;Peptides;Pharmaceutical Preparations;Phosphorylation;plasmepsin;preclinical trial;prevent;promoter;Property;protein function;Protein Kinase;protein structure;Proteins;receptor;recruit;Research;Resolution;Serine Proteinase Inhibitors;Source;STAT1 gene;Structure;Structure-Activity Relationship;Subcellular structure;Tandem Repeat Sequences;Techniques;Transcription Coactivator;Transcriptional Activation;Transferase;Variant;Viral;Viral Physiology;Work;X ray diffraction analysis;X-Ray Crystallography;Zinc

PROJECT_TITLE: Protein Structure


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: 2019-nCoV;adaptive immunity;Adjuvant;Adverse effects;AIDS prevention;Anatomy;Animals;Antibodies;Antibody titer measurement;antibody-dependent cell cytotoxicity;antibody-dependent cellular phagocytosis;Antigens;B-Lymphocytes;Binding;Biological Markers;Biology;Blood;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cellular Immunity;Codon Nucleotides;Combined Vaccines;Complex;CXCL10 gene;CXCL13 gene;CXCR3 gene;cytokine;Data;Dendritic Cells;design;Development;Disease;DNA;DNA delivery;DNA Vaccines;draining lymph node;efficacy testing;Electroporation;env Gene Products;Epitopes;experience;expression vector;FCGR3A gene;FLT3 ligand;Gene Expression;Genes;Goals;HIV;HIV Antigens;HIV Envelope Protein gp120;HIV Infections;HIV vaccine;Human;Humoral Immunities;IL7 gene;Immune;Immune response;Immunity;Immunization;immunogenicity;Immunologics;Immunophenotyping;improved;in vivo;Infection;Infection prevention;Interferon Type II;Interleukin-12;Interleukin-15;Interleukin-6;Intramuscular;Liposomes;Longevity;Lower respiratory tract structure;lymph nodes;Macaca;Maintenance;Measurement;Mediating;Messenger RNA;Methodology;Methods;Modality;Modeling;Molecular;mRNA Expression;Mucosal Immune Responses;mucosal site;Myelogenous;nanoparticle;nanoparticle delivery;neutralizing antibody;novel;Nucleic Acid Amplification Tests;Nucleic Acid Vaccines;Nucleic Acids;Pfizer-BioNTech COVID-19 vaccine;plasmid DNA;Play;predictive marker;Production;Proliferating;Proteins;proteomic signature;Proteomics;Protocols documentation;recombinant viral vector;rectal mucosa;Regimen;Relative Risks;Reporting;Research;response;Risk;RNA;RNA vaccination;RNA vaccine;Role;Route;SARS-CoV-2 infection;scaffold;Secondary Immunization;Severe Acute Respiratory Syndrome;Shapes;simian human immunodeficiency virus;Site;SIV;Stromal Cell-Derived Factor 1;Structure of germinal center of lymph node;Structure of mucous membrane of nose;T cell response;T-Lymphocyte Subsets;Testing;TNF gene;Translating;transmission process;treatment strategy;Vaccinated;Vaccination;vaccine delivery;vaccine development;vaccine efficacy;vaccine formulation;vaccine platform;vaccine strategy;vaccine-induced immunity;Vaccines;vaginal mucosa;vector;vector vaccine;Viral reservoir;Virus

PROJECT_TITLE: Development  testing of nucleic acid-based vaccine for HIV  other indications


NIH_SPENDING_CATS: Bioengineering;Cancer;Genetics;HIV/AIDS;Machine Learning and Artificial Intelligence

PI_NAMEs: WANG, YUN XING M (contact)

PROJECT_TERMS: Atomic Force Microscopy;Biochemical;Biological;biomacromolecule;Biophysics;clinical application;Collaborations;design;Devices;Event;Gene Expression;Goals;insight;interest;Knowledge;learning network;Machine Learning;Methods;molecular dynamics;Molecular Structure;neural network;NMR Spectroscopy;novel strategies;Nucleic Acids;Proteins;Research;RNA;Roentgen Rays;structural biology;Structure;Translating;Translation Process;Translational Research;X-Ray Crystallography

PROJECT_TITLE: Search for the Structural Basis of Biomacromolecular Function and Activity


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Women's Health Research

PI_NAMEs: SHARAN, SHYAM  (contact)

PROJECT_TERMS: Amino Acid Substitution;Arginine;Benign;Binding;Biological Assay;Biological Process;BRCA2 gene;C-terminal;Cancer-Predisposing Gene;carcinogenesis;Cells;Classification;ClinVar;Codon Nucleotides;Defect;design;Development;DNA Binding Domain;DNA Damage;Embryo;epidemiologic data;Exhibits;Female;Fetal Liver;Fibroblasts;Genes;Genome Stability;Genotype;Glutamine;Hematopoietic;Hepatocyte;Human;In Vitro;inhibitor;Lead;Length;male;Malignant Breast Neoplasm;Malignant Neoplasms;Medicine;Mitomycin C;Mouse Embryonic Stem Cells;mouse model;Mus;Mutant Strains Mice;Mutation;Nature;Oligonucleotides;Oligosaccharides;Pathogenicity;Physiological;Poly(ADP-ribose) Polymerase Inhibitor;Positioning Attribute;Predisposition;Radiation;Reporting;response;tumor;tumorigenesis;Variant;variant of unknown significance

PROJECT_TITLE: Functional Analysis of Breast Cancer Susceptibility Genes in Mice


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Mental Health;Neuroblastoma;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: TESSAROLLO, LINO  (contact)

PROJECT_TERMS: Affinity;Aggressive behavior;Alternative Splicing;Alzheimer's Disease;Animal Model;Anxiety;Behavior;Binding;Brain-Derived Neurotrophic Factor;Cell Differentiation process;Clinic;Clinical Trials;Complex;Correlative Study;Development;Disease;Environment;Exhibits;Family;frontal lobe;Generations;Genes;Growth Factor;Human;improved;in vivo;interest;Knowledge;Laboratories;Learning;Length;Link;Maintenance;Malignant Neoplasms;Mediating;Mental Depression;Molecular Mechanisms of Action;mouse model;Mus;neoplastic cell;Nephroblastoma;Nerve Growth Factor Receptors;Nervous System;Neuroblastoma;Neurodegenerative Disorders;neurotrophic factor;Neurotrophic Tyrosine Kinase Receptor Type 1;neurotrophin 4;Normal Cell;Organism;overexpression;Pancreatic carcinoma;Parkinson Disease;Pathway interactions;Peptides;Peripheral;Phosphotransferases;Physiological;preclinical study;Prognosis;Prostate carcinoma;Protein Isoforms;receptor;Receptor Protein-Tyrosine Kinases;Receptor Signaling;Regulation;Research;Role;side effect;Signal Pathway;Structure;Suicide;therapeutic target;transcriptional coactivator p75;tumor;Vertebrates

PROJECT_TITLE: Role of Neurotrophins in the Development of the Mammalian Nervous System


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Neurosciences;Pancreatic Cancer;Pediatric;Pediatric Cancer;Rare Diseases

PROJECT_TERMS: Address;Adult;Aggressive behavior;Animal Model;Birth;Brain-Derived Neurotrophic Factor;Cardiac;Cardiac Myocytes;Cell Physiology;Development;Glucose;Goals;Human;Immune;Immune system;in vivo;Inflammatory Response;insulin secretion;Intervention;Malignant Neoplasms;Mediating;Molecular;Mus;Nephroblastoma;Nervous System;Neuroblastoma;neurotrophic factor;overexpression;Pancreatic carcinoma;Pathway interactions;pharmacologic;Phase;Physiological;Physiology;Prognosis;Prostate carcinoma;Protein Isoforms;receptor;receptor expression;Reporting;Role;Signal Transduction;Structure;Structure of beta Cell of islet;System

PROJECT_TITLE: Role of Trk Receptors in the Development and Function of Non-neuronal Structures


PI_NAMEs: ALADJEM, MIRIT  (contact)

PROJECT_TERMS: Address;Affect;Anaphase;anti-cancer therapeutic;Back;Binding;Biochemical;biochemical tools;Bioinformatics;cancer cell;cancer therapy;Cell Cycle;Cell division;cell growth;Cell Proliferation;cell type;Cells;chemotherapeutic agent;Chromatin;chromatin modification;Chromosome abnormality;chromosome replication;Chromosomes;cis acting element;Clinical;Collaborations;Complex;computerized tools;Consensus;Development;Developmental Therapeutics Program;Distal;DNA;DNA biosynthesis;DNA Damage;DNA Repair Pathway;DNA replication fork;DNA Sequence;DNA-Protein Interaction;Elements;Energy Metabolism;Ensure;Epigenetic Process;Event;Exhibits;Exposure to;Fiber;Future;Genetic;Genome;genome integrity;Genome Stability;genome-wide;Genomic Instability;Health;histone modification;Human;Image;inhibitor;insight;Learning;Link;Location;Malignant Neoplasms;Mammalian Cell;Maps;Mediating;member;Metabolic;Metaphase;Mitosis;Molecular;Molecular Machines;Nature;novel;Oncogenes;Pathway interactions;Phosphotransferases;Play;prevent;programs;Property;protein complex;Protein Family;protein protein interaction;Proteins;recruit;Regulation;Replication Initiation;Replication Origin;replication stress;Replication-Associated Process;Research Personnel;response;Role;segregation;Set protein;Signal Pathway;Signal Transduction;SIRT1 gene;Site;Specificity;Techniques;Testing;tool;TOPBP1 Gene;Translating;translational potential;treatment response;tumorigenesis;ubiquitin ligase;whole genome;Work

PROJECT_TITLE: Initiation of DNA Replication in Mammalian Cells


PI_NAMEs: LARIONOV, VLADIMIR  (contact)

PROJECT_TERMS: Address;Aging;Amino Acids;Aminoglycoside Antibiotics;Aneuploidy;anti-cancer research;Antibodies;Antineoplastic Agents;arm;Artificial Human Chromosomes;Binding;Biogenesis;Bioinformatics;biological adaptation to stress;Biological Assay;BRCA2 gene;cancer cell;cancer therapy;Cancerous;Candidate Disease Gene;Catalogs;Cell Cycle;Cell Cycle Progression;cell growth;Cells;Centromere;centromere protein A;Chromatin;Chromosomal Instability;Chromosomal Stability;Chromosome Segregation;Chromosomes;Cloning;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Collection;cytotoxic;Defect;Development;Diagnostic;Disease;DNA;DNA biosynthesis;DNA Damage;DNA Maintenance;DNA replication fork;Drug Screening;Drug Targeting;early onset;Enhancers;Epigenetic Process;Event;Evolution;experimental study;Foundations;Frameshift Mutation;functional genomics;Future;Gene Duplication;gene function;gene therapy;Generations;Genes;Genetic;Genetic study;Genetic Transcription;genetic variant;Genome;Genomics;Germ-Line Mutation;Goals;Heterogeneity;high throughput screening;Human;Human Chromosomes;Human Genome;Individual;insertion/deletion mutation;Interruption;Journals;Kinetochores;Knock-out;Knowledge;Lead;live cell microscopy;Malignant Neoplasms;Measures;Minor;Mitosis;Modeling;Molecular;mouse genome;Mus;Mutation;Names;National Center for Advancing Translational Sciences;novel;novel therapeutic intervention;Nucleolar Organizer Region;Ontology;Open Reading Frames;Oxidative Stress;PALB2 gene;Patients;Pharmaceutical Preparations;Phenotype;Plant Extracts;plasmid DNA;Plasmids;Play;Poison;Polyploidy;prevent;Process;Productivity;prognostic of survival;Proliferating;Proteins;Publishing;Regulation;Repetitive Sequence;Reporting;Research;Ribosomal DNA;Ribosomal RNA;Ribosomes;Risk;RNA;Role;senescent cell;Signal Transduction;Small Interfering RNA;Structure;synthetic biology;System;Tandem Repeat Sequences;targeted cancer therapy;Technology;Therapeutic;transmission process;treatment strategy;tumor;tumor progression;Universities;Variant;variant detection;vector;Work;Yeasts

PROJECT_TITLE: Human Artificial Chromosomes for Cancer Research and Functional Genomics


PI_NAMEs: ZHANG, YING E (contact)

PROJECT_TERMS: Activins;Alternative Splicing;Apoptosis;Binding;Binding Proteins;Biological;Bone Morphogenetic Proteins;C-terminal;cancer cell;cancer type;CD44 gene;Cell Differentiation process;cell growth;Cell Physiology;Cell Proliferation;Cell surface;Complex;Development;Disease;Drug resistance;Epigenetic Process;Exclusion;Exons;Family;Family member;Genetic;Genetic Transcription;Goals;Growth Factor;Hepatic Stellate Cell;Hepatocyte;Heterogeneous-Nuclear Ribonucleoproteins;Human;Induction of Apoptosis;Investigation;JAK1 gene;MADH3 gene;MADH4 gene;Malignant Neoplasms;MAP Kinase Gene;MAP3K7 gene;MAPK8 gene;Mediating;member;Membrane;Mitogen-Activated Protein Kinases;Molecular;Monoubiquitination;mRNA Precursor;Neoplasm Metastasis;NF-kappa B;Oncogenes;Oncogenic;p38 Mitogen Activated Protein Kinase;Pathway interactions;Pattern;Peptides;Phosphorylation;prevent;promoter;Protein Isoforms;Protein Kinase Interaction;Proteins;Proteomics;receptor;Receptor Serine/Threonine Kinase;Receptor Signaling;Receptor-Interacting Protein;Regulation;Reporting;Research;response;RNA Splicing;RNA-Binding Proteins;Role;Serine;Signal Pathway;Signal Transduction;Site;Smad Proteins;Spliceosome Assembly Pathway;STAT3 gene;TGF-beta type I receptor;Threonine;TRAF6 gene;transcriptome sequencing;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;tumor progression;Tumor Promoters;Tumor Suppressor Proteins;tumorigenesis;Ubiquitination

PROJECT_TITLE: Molecular Mechanisms of TGF-beta Signaling Pathway


NIH_SPENDING_CATS: Cancer;Genetics;Neurosciences

PI_NAMEs: NUSSINOV, RUTH  (contact)

PROJECT_TERMS: Acceleration;Address;Affect;amyloid formation;Automobile Driving;Binding;Binding Sites;Biochemical;brain cell;Calmodulin;Catalysis;CCNE1 gene;CDK2 gene;CDK4 gene;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;Cell Proliferation;cell type;Cells;Chromatin;Clinical;Communities;Complex;Cyclin D1;Cyclin-Dependent Kinases;Cyclins;cytokine;Data;Databases;DNA biosynthesis;Drug Design;drug discovery;Embryo;Entropy;Essential Genes;Feedback;Fibroblast Growth Factor Receptors;G1 Phase;Genes;genomic locus;Germ Lines;GIT1 gene;grasp;Guidelines;Human;Immune system;Immunity;innovation;insight;interest;Interleukin-1;Lead;Life;Lipids;Literature;Malignant Neoplasms;MAP Kinase Gene;Membrane;microbiota;Mission;Modeling;Molecular Conformation;molecular dynamics;monomer;Monomeric GTP-Binding Proteins;morphogens;mutant;Mutation;Mutation Analysis;Nervous System;neurodevelopment;Neurodevelopmental Disorder;Neurons;Noonan Syndrome;Oncogenic;Outcome;overexpression;pathogen;Pathology;Pathway interactions;Pharmaceutical Preparations;Phase;Phase Transition;Phenotype;Phosphorylation;Phosphotransferases;PIK3CG gene;Probability;Proliferating;protein structure;Proteins;PTEN gene;PTPN11 gene;Regulation;Retinoblastoma Protein;S phase;Signal Pathway;Signal Transduction;simulation;Solvents;Somatic Mutation;Specificity;Speed;Structure;Time;Time Factors;tumor;Variant;Vertebral column;Work

PROJECT_TITLE: Protein Structure, Stability, and Amyloid Formation


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases

PROJECT_TERMS: Adenocarcinoma;Affinity;Agonist;alpha helix;Alveolar Rhabdomyosarcoma;anti-cancer research;Apoptosis;autocrine;Binding;Binding Sites;Biological;Calcium;Calcium Signaling;Calmodulin;Calmodulin-Binding Proteins;cancer cell;cancer initiation;Cell Cycle;Cell division;Cell Fate Control;cell growth;Cell Proliferation;cell type;Cells;Cellular biology;Chromatin;Code;Colorectal Cancer;Complex;cytokine;Development;driver mutation;Drug resistance;Early Diagnosis;EGF gene;Electrostatics;Event;Fostering;FOXO1A gene;G2/M Transition;Goals;Growth;Growth Factor;GTPase-Activating Proteins;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Human Pathology;Hydrolysis;Hydrophobic Interactions;Impairment;in silico;Incidence;innovation;insight;KRAS2 gene;KSR gene;Lead;Lysine;Malignant neoplasm of lung;Malignant Neoplasms;MAP Kinase Gene;Maps;Measures;Mediating;MEKs;Mission;Mitogens;Modeling;Molecular Conformation;molecular modeling;mutant;Mutate;Mutation;nanomolar;Neurodevelopmental Disorder;NF1 gene;Normal tissue morphology;Oncogenes;Oncogenic;Output;overexpression;Pancreatic Ductal Adenocarcinoma;pancreatic tumorigenesis;Pathology;Pathway Analysis;Pathway interactions;PAX3 gene;Pharmaceutical Preparations;Phase;Physiological;PIK3CG gene;Play;Population;Post-Translational Protein Processing;Proliferating;prophylactic;Protein Conformation;Protein Isoforms;Proteins;Publications;ral Guanine Nucleotide Exchange Factor;RALGDS gene;RAS driven cancer;ras GTPase-Activating Proteins;Ras/Raf;Regimen;Regulation;response;RNA Splicing;Role;Sampling;Scaffolding Protein;Second Messenger Systems;senescence;senescence associated secretory phenotype;Signal Pathway;Signal Transduction;Site-Directed Mutagenesis;structural determinants;TBK1 gene;Tissues;transcription factor;tumor;tumor growth;Ubiquitination;Variant;Work

PROJECT_TITLE: Biomolecular Recognition and Binding Mechanisms


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

PROJECT_TERMS: 3-Dimensional;Adverse effects;Algorithms;anti-cancer;Binding;Binding Sites;Bioinformatics;Biological;biological research;cancer therapy;Cell Physiology;Cells;Characteristics;Chemical Engineering;Clinical;Combination Drug Therapy;combinatorial;comparative;Computational Biology;Computer Vision Systems;computerized tools;data management;detection method;Docking;dosage;Drug Combinations;drug discovery;Drug resistance;Epigenetic Process;experimental study;Face;flexibility;functional group;Gene Expression;Genetic;globular protein;Goals;in silico;instrument;Integral Membrane Protein;Libraries;Ligands;Location;Malignant Neoplasms;Maps;method development;Methodology;Methods;microbial;mimicry;Modeling;Modernization;Molecular;molecular assembly/self assembly;molecular dynamics;Movement;Mutation;Nature;Oncologist;Oncology;operation;Organism;pathogen;Pathway Analysis;Pathway interactions;Patients;Phage Display;Pharmaceutical Preparations;Population;Prevalence;Probability;programs;protein folding;Protein Fragment;protein protein interaction;protein structure;Proteins;Regimen;Resistance;Resources;Robotics;Selection for Treatments;Series;Signal Pathway;Signal Transduction;single molecule;Site;small molecule;Specific qualifier value;Structure;Surface;targeted treatment;Techniques;Technology;Tissues;tool;treatment planning;tumor heterogeneity;tumorigenesis;Validation;Vertebral column

PROJECT_TITLE: Method Development: Efficient Computer Vision Based Algorithms


NIH_SPENDING_CATS: Asthma;Biotechnology;Cancer;Chronic Obstructive Pulmonary Disease;Lung;Pulmonary Fibrosis;Women's Health Research

PI_NAMEs: KIMURA, SHIOKO  (contact)

PROJECT_TERMS: Affinity;Allergic;allergic airway inflammation;Amino Acid Sequence;Amino Acids;Anti-Inflammatory Agents;anticancer activity;Apoptotic;Asthma;Binding;Biological;Biological Assay;Biological Process;Breast;C-terminal;cancer cell;CASP4 gene;Caspase;Cell Culture Techniques;Cell Death;cell growth;Cell surface;Cells;Chronic Obstructive Pulmonary Disease;Complex;cytokine;Cytosol;Disease;Endocytosis;Escherichia coli;Exhibits;experience;experimental study;Family member;FDA approved;Fetal Lung;Genes;Goals;Growth Factor;Heparan Sulfate Proteoglycan;Homo;Human;immunoregulation;In Vitro;in vitro Assay;in vivo;Inflammasome;Inflammatory;Lacrimal gland structure;Lipopolysaccharides;Lung;Lung Diseases;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;mammaglobin;Mammary Neoplasms;Membrane;Methylation;Molecular Chaperones;Molecular Weight;Morphogenesis;mouse model;Mus;novel;Organ Culture Techniques;Pancreas;Pathway interactions;Peptides;Pharmaceutical Preparations;Physiology;Predisposition;Premature Infant;Preparation;promoter;Prostate;Proteins;Pulmonary Emphysema;Pulmonary Fibrosis;Pulmonary Inflammation;receptor;Recombinant Proteins;Recombinants;Research Project Grants;Role;Salivary Glands;syndecan;System;Therapeutic;Tumor Suppressor Proteins;Uterus

PROJECT_TITLE: Role of Novel Cytokine-like Molecule Secretoglobin (SCGB) 3A2 in Lung


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Immunization;Immunotherapy;Nanotechnology;Orphan Drug;Pancreatic Cancer;Prevention;Rare Diseases;Vaccine Related

PI_NAMEs: BARCHI, JOSEPH JOHN (contact)

PROJECT_TERMS: Adhesives;analog;Annual Reports;Antibodies;Antibody-drug conjugates;Antigens;Award;Binding;Biological Assay;biophysical techniques;C Type Lectin Receptors;Carbohydrates;Cells;chimeric antigen receptor T cells;Collaborations;commercialization;cytotoxicity;Dendritic Cells;design;Development;Diagnostic;Drug Delivery Systems;Epitopes;Extramural Activities;Glucans;Glycopeptides;Gold;Hybrids;Image;in vivo;interest;Lead;Ligands;Magnetism;Malignant neoplasm of pancreas;Malignant Neoplasms;Medical Research;Metals;Methods;mimetics;Modeling;Monoclonal Antibodies;Mucins;Mus;nanoGold;nanoparticle;novel;novel therapeutics;novel vaccines;Organic Synthesis;overexpression;Pancreas;Pancreatic duct;pancreatic neoplasm;particle;patient derived xenograft model;Pharmaceutical Preparations;physical property;pre-clinical research;Proteins;Reproducibility;Research Personnel;Therapeutic;Therapeutic Agents;therapy development;Toxic effect;tumor;Tumor-Associated Carbohydrate Antigens;vaccine platform;Vaccines;Work

PROJECT_TITLE: Glycopeptide Antigen-bearing Nanoparticles for Passive and Active Antitumor Therapy for Pancreatic Cancer


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases

PI_NAMEs: FIGG, WILLIAM DOUGLAS (contact)

PROJECT_TERMS: abiraterone;advanced prostate cancer;Affect;ancestry analysis;androgen deprivation therapy;androgen independent prostate cancer;Androgens;Asian;Automobile Driving;Benign;Binding;Biological;Biology;biomarker discovery;black men;Black race;Cancer Biology;cancer genomics;cancer risk;cancer type;Candidate Disease Gene;candidate identification;Castration;Cell Line;Clinical;clinically relevant;cohort;Collaborations;Complex;Data;Data Set;Development;differential expression;Diffusion;Disease Management;Disease Progression;DNA Sequence Alteration;drug development;Drug Interactions;extracellular vesicles;Family;Frequencies;Future;Genes;Genetic;Genetic Polymorphism;Genetic Predisposition to Disease;Genetic Transcription;Genetic Variation;GENIE;Genomics;Germ Lines;Germ-Line Mutation;Goals;Haplotypes;health disparity;Hereditary Malignant Neoplasm;Heritability;Hyperplasia;Impairment;improved;Incidence;Individual;Institution;interest;Investigation;Kinetics;Knowledge;Laboratories;liquid biopsy;Malignant neoplasm of prostate;Mediating;member;men;microRNA biomarkers;MicroRNAs;minimally invasive;Molecular;Molecular Biology;Molecular Genetics;mortality;mouse model;Mutation;new therapeutic target;novel;Organic Anion Transporters;Outcome;overexpression;Pathway interactions;Patients;Pharmacogenetics;Pharmacogenomics;Plasma;precision medicine;precision oncology;predictive marker;promoter;prostate cancer cell line;prostate cancer progression;prostate cancer risk;Prostatectomy;Race;racial difference;Regulatory Element;Research;Resistance;resistance mechanism;Risk;Risk Assessment;Role;Sample Size;Sampling;Screening for cancer;Single Nucleotide Polymorphism;solute;Source;steroid hormone;targeted treatment;Testing;Testosterone;The Cancer Genome Atlas;Therapeutic;therapy resistant;Time;Tissues;Transcript;transcription factor;Translational Research;treatment response;trend;tumor;Tumor Markers;uptake;Xenograft procedure

PROJECT_TITLE: Genetics and Molecular Mechanisms of Prostate Cancer


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Complementary and Integrative Health

PI_NAMEs: CHERUKURI, MURALI  (contact)

PROJECT_TERMS: Adjuvant;aerobic glycolysis;Aftercare;ascorbate;Biochemical;Cell Nucleus;Chemicals;density;Dependence;Derivation procedure;Dose;Electron Spin Resonance Spectroscopy;experimental study;Hypoxia;Image;imaging study;Implant;improved;in vivo;in vivo imaging;Intravenous;kidney imaging;Label;Leg;magnetic field;Magnetic Resonance Imaging;Magnetism;Maps;Measures;Metabolic;metabolic imaging;Metabolism;molecular imaging;Monitor;Mus;Nature;Normal tissue morphology;normoxia;Oxygen;Oxygen Consumption;Pancreatic Ductal Adenocarcinoma;Pharmaceutical Preparations;Pharmacologic Ascorbate;Physiology;Prodrugs;Protons;Pyruvate;Reactive Oxygen Species;response;Signal Transduction;Techniques;Time;Tracer;treatment effect;treatment response;tumor;tumor hypoxia;Tumor Volume;Water

PROJECT_TITLE: Time Domian Electron Paramagnetic Resonance Imaging


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Pediatric;Pediatric Cancer;Rare Diseases

PROJECT_TERMS: aerobic glycolysis;Aftercare;Biochemical;Body Water;cancer cell;cancer imaging;Cell Cycle Kinetics;Cell Nucleus;Cell Proliferation;Cells;Chemicals;clinical development;Colorectal;contrast imaging;density;Dependence;Deuterium;Glycolysis;HT29 Cells;Image;In Vitro;in vivo;inhibitor;Label;Magnetic Resonance Imaging;Magnetism;Malignant Childhood Neoplasm;Measures;Metabolic;metabolic imaging;Metabolism;Methods;molecular imaging;Monitor;mouse model;Mus;Nature;nicotinamide phosphoribosyltransferase;Normal tissue morphology;novel;Oxidative Phosphorylation;pancreatic neoplasm;Pathway interactions;Phase;Physiology;Production;Proliferating;Protons;Pyruvate;Research;Rhabdomyosarcoma;Signal Transduction;Techniques;Tissues;Tracer;treatment effect;treatment response;tumor;tumor growth;tumor xenograft;Visualization;Water;Xenograft procedure

PROJECT_TITLE: Overhauser Enhanced Magnetic Resonance Imaging (OMRI)


NIH_SPENDING_CATS: Cancer

PI_NAMEs: ST CROIX, BRADLEY D (contact)

PROJECT_TERMS: Adult;angiogenesis;Antibodies;blood vessel development;Cell surface;conditional knockout;Endothelial Cells;Endothelium;Gene Expression Profiling;Genes;Goals;Growth;interest;Knockout Mice;Laboratories;Mus;Neoplasms in Vascular Tissue;Pathologic;Physiological;Physiology;response;Role;Stress;Therapeutic;tumor;Tumor Cell Line;tumor microenvironment;tumorigenesis

PROJECT_TITLE: Functional Analysis of TEM5 and TEM8


NIH_SPENDING_CATS: Cancer;HIV/AIDS;Infectious Diseases

PI_NAMEs: KEWALRAMANI, VINEET N (contact)

PROJECT_TERMS: Affect;Anti-viral Therapy;Area;C-terminal;Cell Nucleus;Cells;Chromatin;Companions;Complex;Cytoplasm;Data;Dependence;Equine Infectious Anemia Virus;Event;Excision;experimental study;Feline Immunodeficiency Virus;Genes;Genetic;Genetic Transcription;helicase;HIV;HIV-1;HIV-2;Infection;Integration Host Factors;Karyopherins;Manuscripts;Mutation;Nuclear;Nuclear Pore;Nuclear Pore Complex;Pattern;Physical condensation;Pore Proteins;Proteins;Regulation;RNA;Role;Route;Series;SIV;trafficking;Viral Physiology;viral resistance;Virus;Work

PROJECT_TITLE: The role of CPSF6 in HIV-1 infection


PROJECT_TERMS: Affect;Affinity;Anti-viral Agents;Area;Attenuated;Binding;C-terminal;Cell Line;Cell membrane;Cell Nucleus;cell type;Cells;Cellular biology;Complex;Cyclosporine;Cytoplasm;Dependence;Diameter;Diffusion;Dipeptides;Docking;Exhibits;experimental study;Filament;Genes;Genome;genome wide screen;Glycine;Hela Cells;heterokaryon;HIV-1;Host Factor 1 Protein;Human;Human Cell Line;Human immunodeficiency virus test;Impairment;Infection;inhibitor;Integration Host Factors;Interphase Cell;Jurkat Cells;Karyopherins;knock-down;Macromolecular Complexes;macromolecule;Manuscripts;Mediating;Membrane;Membrane Fusion;Modeling;molecular mass;mutant;Mutation;N-terminal;Nature;Night Monkey;Nuclear;Nuclear Envelope;Nuclear Import;Nuclear Pore;Nuclear Pore Complex;Nuclear Pore Complex Proteins;nucleocytoplasmic transport;Nucleoplasm;particle;Pathway interactions;Phenotype;Play;Pore Proteins;prevent;Process;Proline;Property;Proteins;Publishing;receptor;Reporter;Resistance;Retroviridae;Reverse Transcription;RNA;Role;Route;Series;Side;Site;Small Interfering RNA;Testing;trafficking;TRIM5 gene;Variant;Vesicular stomatitis Indiana virus;Viral;Virus;Virus Replication;working group

PROJECT_TITLE: HIV-1 passage through the nuclear pore complex


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases

PI_NAMEs: AMBS, STEFAN  (contact)

PROJECT_TERMS: advanced disease;Affect;African;African American;African American population;African ancestry;Age;allostatic load;American;Area;Award;Baltimore;bead chip;Biological;Blood;California;cancer diagnosis;cancer health disparity;Cancer Patient;cancer survival;Case/Control Studies;Cessation of life;Chemotaxis;Child;Chronic;circulating biomarkers;Cities;Classification;Clinical;cohort;Collaborations;Collection;Control Groups;cooking;Data;database of Genotypes and Phenotypes;Databases;deprivation;design;Development;Diabetes Mellitus;Diagnosis;Diet;Dietary Factors;Disease;disease diagnosis;Disease Marker;Disease Outcome;Disease Progression;disorder risk;DNA Methylation;Enrollment;Environmental Risk Factor;ethnic difference;European;European ancestry;Female;follow-up;Freezing;Frequencies;gene environment interaction;Gene Expression;Gene Expression Profile;Genetic;genetic risk factor;genetic signature;genetic variant;genome-wide;Genotype;Germ Lines;Ghana;Gleason Grade for Prostate Cancer;Goals;Guidelines;Hereditary Malignant Neoplasm;high risk;Hospitals;Household;Household Heads;Immune;immune function;Immune response;Immunooncology;indexing;Individual;Infection;Inflammation;inflammatory marker;Laboratories;Link;male;Malignant neoplasm of prostate;Maps;Maryland;Measures;Mediating;Medical;Medical center;Medical History;Medical Records;men;metabolome;Minor;Molecular;Molecular Profiling;Morehouse School of Medicine;mortality;Motor Vehicles;Mutation Spectra;National Comprehensive Cancer Network;Native American Ancestry;Neighborhoods;Nigerian;Occupational;Operative Surgical Procedures;Outcome;Paraffin Embedding;Participant;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Penetrance;Pharmaceutical Preparations;Phase;Pilot Projects;polygenic risk score;population based;Poverty;precision medicine;Procedures;prospective;prostate cancer risk;Prostatectomy;Prostatic Neoplasms;protein activation;protein expression;Proteins;Protocols documentation;PSA level;Public Assistance;Race;racial difference;Recording of previous events;Records;recruit;Recurrent disease;Reporting;Research;Risk;Risk Factors;risk variant;Role;Secure;Sexually Transmitted Diseases;Signal Pathway;smoking exposure;Socioeconomic Status;socioeconomics;Specimen;Stress;Study Subject;Surveys;survival disparity;Susceptibility Gene;systemic inflammatory response;Time;Tissue Sample;Tissues;TNM;Tobacco use;Tobago;tumor;Tumor Biology;Tumor Immunity;Tumor Markers;Tumor Suppression;Unemployment;United States Department of Veterans Affairs;Universities;Update;Urine;Virus Diseases;West Indies;Work

PROJECT_TITLE: Maryland Prostate Cancer Case-Control Study


PI_NAMEs: HU, WEI-SHAU  (contact)

PROJECT_TERMS: APOCEC3G gene;Cell Nucleus;Cells;Chromosomes;Collaborations;Complex;Cytoplasm;dimer;Dissociation;DNA;DNA biosynthesis;ds-DNA;Enzymes;Epidemic;Event;Evolution;Family;genetic information;Genetic Recombination;Genome;Goals;HIV;HIV Genome;HIV-1;Human;Infection;Infection prevention;insight;Knowledge;Lentivirus Vector;Location;Molecular;novel;nucleic acid-based therapeutics;Parents;particle;pathogen;Peptides;prevent;Process;Proviruses;Publishing;Research;Resistance;Retroviridae;Reverse Transcription;RNA;Role;Science;Time;Treatment Protocols;Vaccines;vector;vif Gene Products;Viral;viral DNA;Viral Genome;Viral Proteins;viral RNA;Virus;virus genetics;Virus Integration;Virus Replication

PROJECT_TITLE: Understanding Retroviral Reverse Transcription, Recombination, and Replication


PROJECT_TERMS: Affect;Behavior;Cell membrane;Cell Nucleus;Cells;Cytoplasm;dimer;Ensure;Epidemic;Event;Evolution;Family;Fluorescence Microscopy;gag Gene Products;genetic information;Genome;Goals;Guanosine;HIV;HIV-1;Human;imaging study;Infection;insight;Kinetics;Knowledge;Length;live cell imaging;Location;Minor;Modeling;novel strategies;Parents;particle;pathogen;Proteins;Proviruses;Research;Retroviridae;RNA;Role;Site;Structure;T-Lymphocyte;Testing;trafficking;Transcription Initiation Site;Travel;Treatment Protocols;Vaccines;Viral;Viral Genome;Viral Packaging;Viral Proteins;viral RNA;Virion;Virus;Virus Assembly;virus genetics;Virus Replication

PROJECT_TITLE: Defining Mechanisms of HIV-1 Gag:RNA Interactions and Virus Assembly