ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Complementary and Integrative Health;Emerging Infectious Diseases;Infectious Diseases;Networking and Information Technology R&D (NITRD);Rare Diseases;Telehealth

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Mobile health technologies are a promising strategy for collection of data on infection diseases. However, differences in understanding of these newly introduced mHealth technologies may pose significant ethical concerns around respect, consent, confidentiality, and beneficence. This supplement project will identify key differences in understanding of mHealth concepts between populations and develop guiding principles for ethical implementation of mHealth surveillance systems in LMIC settings.

PI_NAMEs: EVANS, TIERRA SMILEY (contact);WILKES, MICHAEL S

PROGRAM_OFFICER_NAME: NEWSOME, BRAD

PROJECT_TERMS: Address;Adoption;Africa South of the Sahara;Alternative Medicine;Award;Beneficence;Biodiversity;Bioethics;Bioethics Consultants;cloud storage;Collaborations;collaborative approach;commune;Communicable Diseases;Communities;community engaged approach;Complex;Congo;Consent;Country;Data;Data Collection;design;detection platform;Disease;Disease Outbreaks;Disease Surveillance;Ebola Hemorrhagic Fever;Economics;Educational workshop;Elements;Ensure;Ethical Issues;Ethics;Ethnic Origin;Failure;Focus Groups;forest;Future;Guidelines;Health;health data;Health Technology;Human;improved;Income;Individual;Infection;International;Intervention;learning outcome;Linguistics;Location;low and middle-income countries;Manuscripts;Marburg Virus Disease;member;Methods;mHealth;Multimedia;new outbreak;novel;Oral;pandemic disease;parent project;Parents;Participant;patient engagement;Population;Procedures;Process;programs;Recording of previous events;recruit;Research;Research Ethics;Research Personnel;Risk;Series;social;Social Identification;Societies;sound;spillover event;Subgroup;success;Surveillance Program;System;Technology;technology intervention;technology platform;Training;Uganda;Zoonoses;zoonotic spillover

PROJECT_TITLE: Advancing Bioethics of One Health Data Capture at the Point of Zoonotic Spillover in the Congo Basin Forest Perimeter


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: MEMPHIS

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: NARRATIVE (RELEVANCE STATEMENT) Acute leukemia (ALL) is the commonest childhood tumor and a leading cause of cancer death in the young. My research has used integrated genomic discovery, experimental modeling and therapeutic development to identify and characterize the genomic drivers of disease and develop new treatment approaches. My proposed research program will build upon my prior discoveries to pursue several new conceptually and technically innovative areas central to advancing cure rates for these diseases, including the mechanistic basis of enhancer deregulation in leukemia, the role of BCL11B in lineage ambiguous leukemia, the mechanistic role and potential for therapeutic targeting of LMO2/STAG2 alterations in leukemia, the role of liquid-liquid phase separation mediated by fusion oncoproteins in leukemia, and their potential for therapeutic targeting. I will also develop innovative protein degradation approaches using molecular glues to degrade hitherto intractable cancer drivers of high-risk leukemia.

PI_NAMEs: MULLIGHAN, CHARLES G. (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute;Acute leukemia;adult leukemia;Area;Bar Codes;Cancer Etiology;Cause of Death;Cell Lineage;Cells;Cessation of life;Childhood Leukemia;Chromatin;Clonal Evolution;Collaborations;Development;Disease;Engineering;Enhancers;Event;Experimental Models;Fusion Oncogene Proteins;Gene Expression;Genetic Transcription;Genomics;Glues;Goals;Hematopoietic;high risk;improved;improved outcome;innovation;insight;leukemia;leukemogenesis;Liquid substance;LMO2 gene;Malignant Neoplasms;Mediating;Molecular;Molecular Bank;mouse model;multiple omics;novel;novel diagnostics;novel therapeutic intervention;Pediatric Neoplasm;Phase;Physical condensation;programs;protein degradation;Research;Role;small molecule libraries;targeted treatment;Taxonomy;Therapeutic;therapeutic development;therapeutic target;Translating;Treatment Failure

PROJECT_TITLE: Translating genomic discoveries to improved outcomes for high risk acute leukemia


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative Community college (CC) students suffer high rates of depression and anxiety in the face of daunting life challenges (e.g., housing and food insecurity) without adequate mental health resources. This Center aims to optimize the effectiveness and implementation of a system for screening, tracking, and treating anxiety and depression in a low-income, diverse community college student population, and explore pathways for sustainability and spread to other community colleges.

PI_NAMEs: CRASKE, MICHELLE G (contact);WOLITZKY-TAYLOR, KATE BASIA

PROGRAM_OFFICER_NAME: ROONEY, MARY

PROJECT_TERMS: Acceleration;Address;Adherence;Administrator;Advocacy;Affect;Algorithms;Anxiety;anxiety treatment;Area;Awareness;behavior influence;Behavioral;Budgets;California;care systems;Caring;Chronic;Clinical;Clinical Sciences;Cognitive;Cognitive Therapy;cohort;Collaborations;college;Communities;community barrier;community college;cost effectiveness;County;cultural competence;Data;Data Science;data streams;Decision Making;design;Detection;digital mental health;disparity gap;early life adversity;Economics;Education;Effectiveness;ethnic minority;Ethnic Origin;Evaluation;evidence base;falls;Financial Hardship;food insecurity;Funding;Geography;Goals;Health Care Costs;health disparity;health literacy;Health Resources;health service use;Health Status;Healthcare Systems;Hearing;higher education;Homelessness;Housing;implementation barriers;implementation efforts;implementation facilitators;implementation framework;implementation science;improved;innovation;Investigation;Investments;Learning;Life;Life Stress;Los Angeles;Low income;Mental Depression;Mental Health;Mental Health Services;Methods;Mind;minority student;model generalizability;Modeling;operation;Outcome;Pathway interactions;peer coaching;Performance;Persons;Pilot Projects;pilot trial;Policy Maker;Population;prediction algorithm;predictive modeling;Prevention;programs;Provider;Public Health;Quality of Care;Race;racial minority;rapid detection;recruit;reduce symptoms;Research Personnel;Research Project Grants;Research Support;Resources;Risk;Risk Reduction;Sampling;satisfaction;Science;screening;Self Efficacy;Self-Injurious Behavior;Services;Severities;social determinants;social stigma;socioeconomics;Source;Students;substance use;success;suicidal;Suicide;Suicide prevention;Supervision;Surveys;Symptoms;System;Testing;tool;Training;treatment response;Triage;Unemployment;university student;Update;uptake;user centered design

PROJECT_TITLE: Screening, Tracking and Treatment for Anxiety and Depression in Community Colleges


ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: Narrative High-grade gliomas, including the particularly aggressive brain tumor known as glioblastoma, present significant challenges for treatment due to their invasive nature and tendency to recur after surgery. Our project aims to assist with surgical planning and improve surgical outcomes by combining advanced imaging techniques with a method called fluorescence-guided surgery, which helps surgeons more accurately identify and remove tumor tissue. By analyzing how brain tumors look under combined imaging modalities, we plan to develop a predictive model that can inform surgeons of tumor characteristics in advance of surgery.

PI_NAMEs: CANOLL, PETER ;SWANSON, KRISTIN R (contact)

PROGRAM_OFFICER_NAME: DUECK, HANNAH RUTH

PROJECT_TERMS: Address;Aminolevulinic Acid;Area;Biopsy;Brain Neoplasms;Cell Density;Characteristics;chemotherapy;Disease;dosage;Excision;Fluorescence;fluorescence-guided surgery;Gadolinium;Glioblastoma;Glioma;Image;imaging modality;Imaging Techniques;improved;Infiltration;Invaded;Link;Magnetic Resonance Imaging;Maps;Mathematics;Methods;model development;Modeling;MRI Scans;Nature;neoplastic cell;neuro-oncology;Obstruction;Operative Surgical Procedures;parent project;Patients;Photobleaching;predictive modeling;prognostic model;prognostic value;Radiation therapy;radiomics;Recurrence;Research;Residual Neoplasm;Sensitivity and Specificity;Sex Differences;sexual dimorphism;Surgeon;surgery outcome;survival outcome;Survival Rate;Techniques;Tissues;Treatment Effectiveness;tumor;Tumor Burden;Tumor Tissue;Work

PROJECT_TITLE: Green Diversity Supplement: Predicting 5-ALA Fluorescence Status in High Grade Gliomas Based on MRI Features


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE Our supplement revitalizes Hawaii's biomedical research by embedding data science into projects from RCMI and their collaborators, targeting local health disparities. Introducing a specialized curriculum, workshops, and summer bootcamp, we aim to empower RCMI students and researchers with advanced tools, such as cloud computing, fostering innovation and collaborative research. This effort aligns with our dedication to diversity, ensuring broad access to data science training and creating impactful health solutions for Hawaii's underserved communities, thereby enhancing research capacity and health equity statewide and beyond.

PI_NAMEs: HEDGES, JERRIS ROBERT (contact);MOKUAU, NOREEN

PROGRAM_OFFICER_NAME: LAI, GABRIEL Y

PROJECT_TERMS: Address;analytical method;Area;Artificial Intelligence;Automobile Driving;Award;Back;Behavioral Sciences;Biomedical Research;Clinical Sciences;Cloud Computing;Collaborations;Collection;Communities;Competence;Complex;complex biological systems;computerized data processing;Computing Methodologies;Data;Data Analyses;Data Analytics;data integration;Data Science;Data Set;Dedications;design;Development;Disease;Disparity;Education;Educational Activities;Educational Curriculum;Educational workshop;empowerment;Ensure;Ethics;Evolution;experience;Fostering;Foundations;Future;Grant;Hawaii;Health;Health Disparities Research;health disparity;health equity;Health Sciences;human capital;Infrastructure;innovation;insight;institutional capacity;interest;Intervention;Learning;Manuscripts;Methodology;Mission;next generation;Outcome;Outcomes Research;Pattern;Play;Population Heterogeneity;Productivity;programs;Publications;remote location;Research;Research Personnel;Role;Science;science teacher;Scientist;Shapes;Site;skill acquisition;skills;Social Sciences;Strategic Planning;Structure;Students;Talents;Technology;tool;Training;Training and Education;Training Programs;Translational Research;underserved community;Work

PROJECT_TITLE: Empowering Data Science research and training for RCMI researchers and students


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: MILWAUKEE

ORG_NAME: CLEMENT J. ZABLOCKI VA MEDICAL CENTER

ORG_STATE: WI

PHR: The Department of Veteran’s Affairs provides care for nontraumatic spinal cord disorders such as the degenerative disease cervical spondylotic myelopathy (CSM). CSM is the most common cause of spinal cord dysfunction in older adults, causes significant functional impairments and reduced quality of life, and is a risk factor for subsequent traumatic spinal cord injury. The current proposal seeks to understand the spinal cord damage incurred in CSM by examining the underlying electrical and perfusion dysfunctions in an animal model. These studies will elucidate crucial links between compression of the spinal cord and the resulting cell damage and neurologic dysfunction. The results of this study will help establish causal factors of CSM and will offer new approaches for detecting, monitoring, and guiding interventions to help improve the lives of Veterans with this condition.

PI_NAMEs: BUDDE, MATTHEW D (contact)

PROJECT_TERMS: Acute;Affect;aged;aging population;Anatomy;Angiography;Animal Model;Animals;Area;behavior test;Blood Vessels;bone;Caring;Cell Death;cell injury;Central Nervous System;Cervical;Cessation of life;Chronic;Clinical Research;clinical translation;clinically relevant;clinically significant;cohort;Coupled;Data;Degenerative Disorder;demographics;Devices;Diagnosis;Diagnostic;diagnostic biomarker;diagnostic value;Disease;Dorsal;Electrodes;Electrophysiology (science);Emotional;Ensure;Event;Evolution;experimental study;Functional disorder;Functional impairment;Glucose;Goals;gray matter;high risk;Human;Implant;improved;improved outcome;Individual;Injections;Injury;interdisciplinary approach;Intervention;Left;Lesion;Link;Magnetic Resonance Imaging;Measures;Mechanics;Metabolic;Methods;military veteran;Modeling;Monitor;Neurologic;Neurologic Dysfunctions;Neurons;novel strategies;Numbness;older adult;Operative Surgical Procedures;Outcome;Oxygen;Pain;Paralysed;Pathology;Patients;Perfusion;physical insult;Polymers;pre-clinical;pressure;pressure sensor;Process;Quality of life;Rattus;Recovery;Research;Research Personnel;Risk;Risk Factors;Rodent;Rodent Model;Role;Site;spasticity;Spinal;Spinal Cord;spinal cord compression;Spinal cord damage;Spinal Cord Diseases;Spinal cord grey matter structure;Spinal cord injury;Stroke;Subdural space;Symptoms;Telemetry;Time;Tissues;translational diagnostics;translational potential;Trauma;Traumatic Brain Injury;Uncertainty;United States Department of Veterans Affairs;Veterans;Well in self

PROJECT_TITLE: Spreading Depolarizations and Perfusion in Non-traumatic Spinal Cord Injury

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ORG_CITY: RICHMOND

ORG_NAME: VA VETERANS ADMINISTRATION HOSPITAL

ORG_STATE: VA

PHR: PROJECT NARRATIVE Cholesterol, a structural component of all mammalian cell membranes, is particularly important in regulation of cancer and cancer stem cells (CSCs) growth. StarD5 is a protein involved in intracellular cholesterol movement towards plasma membrane and is found at high levels in human colon cancers. The proposed studies could unveil new anti-cancer agents that target PM cholesterol to control CSC growth leading to long-term remission or cure for colon cancer.

PI_NAMEs: PATEL, BHAUMIK B (contact)

PROJECT_TERMS: Affect;Animal Cancer Model;Antineoplastic Agents;biophysical properties;Brain;cancer cell;Cancer Control;Cancer Etiology;cancer initiation;cancer seeding;cancer stem cell;cancer therapy;Carrier Proteins;Cell membrane;Cells;Cessation of life;Chemicals;Chemoresistance;chemotherapeutic agent;chemotherapy;Chemotherapy-Oncologic Procedure;Cholesterol;Cholesterol Homeostasis;Clinical;Colon;Colon Carcinoma;Colorectal Cancer;colorectal cancer treatment;CXCR4 gene;Data;Disease remission;Dose;Drug Kinetics;efficacy evaluation;Epidermal Growth Factor Receptor;FDA approved;fluidity;Fluorouracil;Frequencies;Generations;genetic variant;Goals;Growth;Growth Factor;Growth Factor Receptors;HCT116 Cells;HT29 Cells;Human;In Vitro;in vivo;Inhibition of Cancer Cell Growth;inhibitor;innovation;insight;Insulin-Like-Growth Factor I Receptor;Intestines;Intracellular Transport;Invaded;knock-down;Knock-out;Knockout Mice;Laboratories;Lipids;Liver;Malignant Neoplasms;Mammalian Cell;Manuscripts;Membrane;Membrane Fluidity;Molecular;Morphology;Movement;Mucous Membrane;Mus;neoplastic cell;novel;novel anticancer drug;Obesity;Organ;Organoids;Outcome;overexpression;oxaliplatin;panitumumab;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Platinum Compounds;Play;progenitor;prognostic significance;Property;Protein translocation;Proteins;Receptor Signaling;refractory cancer;Regulation;Relapse;Role;Schedule;self-renewal;Signal Transduction;small hairpin RNA;small molecule inhibitor;spheroids;stem;stem cell growth;stem cell self renewal;steroidogenic acute regulatory protein;synergism;targeted agent;targeted cancer therapy;targeted treatment;Testing;therapeutic target;Thinness;Tissues;Toxic effect;Treatment Efficacy;tumor;tumor eradication;tumor growth;tumor progression;Tyrosine Phosphorylation;Xenograft procedure

PROJECT_TITLE: StarD5, a protein that translocates cholesterol to the plasma membrane, is a novel target for Colon Cancer


ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

ORG_STATE: CO

PHR: Post-traumatic stress disorder (PTSD) is a highly prevalent and debilitating condition afflicting the U.S. Veteran population. Vagus nerve intervention holds significant promise for treating this disorder, and associated maladies, but current electrical nerve stimulation devices lack the necessary specificity to precisely study and modulate nerve pathways associated with PTSD. Here, an optogenetic vagus nerve stimulation system will be developed, in which light-sensitive opsin actuators genetically expressed to specific cell-types enable targeted neuromodulation. This new approach to neural intervention will be applied in an electric footshock rodent model of PTSD. The impact of select vagal fiber stimulation on the extinction of associative fear, as well as anxiety, will be assessed.

PI_NAMEs: FONTAINE, ARJUN K (contact)

PROJECT_TERMS: 3D Print;Adverse effects;Amygdaloid structure;Animal Model;Anti-Inflammatory Agents;Anxiety;anxiety reduction;Attenuated;Autonomic nervous system;awake;Behavior;Behavioral;biomaterial compatibility;Brain;Brain region;Cardiac;cell type;Cells;Cervical;cholinergic;Cholinergic Fibers;Chronic;Clinical;Clinical Data;Clinical Trials;cohort;comorbidity;conditioned fear;Conditioned Stimulus;Control Animal;Crohn's disease;Cues;Custom;cytokine;Data;Development;Devices;Diabetes Mellitus;Disease;Effectiveness;Electric Stimulation;Epilepsy;Exposure to;Extinction;Fiber;field study;Freezing;Fright;Future;Genetic;Glutamates;Head;Heart Diseases;Heart Rate;Hippocampus;Implant;implantable device;improved;improved outcome;in vivo;Individual;Inflammation;Inflammation Mediators;Inflammatory;interest;Intervention;Investigation;Light;light emission;Lighting;Longevity;Measurement;Measures;Mechanics;Mental Depression;Mental disorders;Methodology;Methods;military veteran;Modeling;Moods;mouse model;Mus;Nature;Nerve;Nerve Tissue;neural;neural circuit;neuroregulation;novel;novel strategies;Operative Surgical Procedures;Opsin;Optic Nerve;optical fiber;Optics;optogenetics;Organ;Outcome;Pathology;Pathway interactions;Patients;Peripheral Nerves;Polyethylene Glycols;Post-Traumatic Stress Disorders;pre-clinical;Property;Protocols documentation;Reaction;Research;response;Rheumatoid Arthritis;Risk Factors;Rodent;Rodent Model;selective expression;Shock;Signal Transduction;Specificity;Spleen;Stimulus;Stress;subcutaneous;Surgical sutures;System;Testing;Therapeutic;Therapeutic Effect;Therapeutic Intervention;Time;Tissues;tool;Trauma;vagus nerve stimulation;Vagus nerve structure;Validation;Veterans;Viral;Visceral;Work

PROJECT_TITLE: Investigation of an Optogenetic Vagus Nerve Stimulation Device in an Animal Model of Post-traumatic Stress Disorder


FUNDING_MECHANISM: OTHERS

ORG_CITY: BALTIMORE

ORG_NAME: BALTIMORE VA MEDICAL CENTER

ORG_STATE: MD

PHR: Myelin protects and amplifies the signals in our brain and spinal cord. Multiple sclerosis (MS) develops when the immune system attacks this myelin, resulting in damage and symptoms like motor and vision loss. MS is prevalent in women and Veterans, who have no curative treatment options and many treatments leave patients vulnerable to infection. These life-long treatments often require injections that limit independence and diminish quality of life. The goal of this project is the development of therapies that specifically counter the attack against myelin, while leaving healthy immunity intact. This will be achieved by engineering therapeutics that precisely promote regulatory immune cells to deactivate the cells that attack myelin. The research will leverage nanotechnology for the assembly and delivery of these therapeutics to skin, where immune cells are dense and were recently shown to regulate autoimmunity. This approach could impact Veterans quality-of-life by providing an effective therapy, without side effects, that is easily and independently applied to skin as a small patch.

PI_NAMEs: OAKES, ROBERT SMITH (contact)

PROJECT_TERMS: Address;Affect;Allergens;Allergy Shot;Animal Model;antagonist;Antibodies;Antigen Targeting;Antigen-Presenting Cells;Antigens;Autoantigens;Autoimmune;Autoimmune Diseases;autoimmune pathogenesis;Autoimmunity;Automobile Driving;Axon;B-Lymphocytes;Biological Assay;Biological Markers;Biological Response Modifiers;Blindness;Brain;career;career development;cell type;Cells;Central Nervous System;Clinic;Clinical Data;Cues;curative treatments;cytotoxic;Dangerousness;Data;Delayed Hypersensitivity;density;design;Disease;Dose;draining lymph node;effective therapy;efficacy testing;Engineering;Ensure;Environment;experience;Experimental Autoimmune Encephalomyelitis;extracellular;Family;Fluorescence;Generations;Goals;Growth;Immune;immune function;Immune signaling;Immune system;Immune Targeting;Immune Tolerance;Immunity;Immunocompromised Host;Immunologics;immunoregulation;improved;In Vitro;in vivo;in vivo imaging;Infection;Inflammation;Inflammatory;Injections;intradermal injection;Length;Libraries;Ligands;Mentors;migration;Molecular;Motor;motor deficit;mouse model;Multiple Sclerosis;multiple sclerosis patient;multiple sclerosis treatment;Myelin;Myelin Sheath;nanomaterials;Nanotechnology;nanotechnology platform;Needles;neuroinflammation;Neurologic;Neurophysiology - biologic function;novel;Onset of illness;Organ;Pain;Paralysed;pathogen;Pathogen detection;Pathway interactions;Patients;Pattern;Peptides;Pharmaceutical Preparations;Phenotype;Polymers;Population;Predisposition;preservation;prevent;Quality of life;Receptor Signaling;Regulatory T-Lymphocyte;Research;restraint;risk mitigation;Role;Self Administration;side effect;Signal Pathway;Signal Transduction;Site;Skin;Specificity;Spinal Cord;subcutaneous;Surface;Surveys;Symptoms;T-Lymphocyte;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;therapy development;Tissues;Toll-Like Receptor Pathway;Toll-like receptors;Tracer;trafficking;Treatment Efficacy;Veterans;Visual impairment;Women's prevalence

PROJECT_TITLE: Leveraging nanotechnology and skin delivery to drive selective immune tolerance for Multiple Sclerosis


ORG_CITY: GAINESVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: FL

PHR: Closed head traumatic brain injury (CH-TBI) has been a major component of injury in war with lingering quality of life eroding disabilities such as chronic pain and headache that produce a substantial health care responsibility. There are also rapidly growing concerns that mild/moderate TBI is a significant risk factor for other chronic disabilities. Accordingly, there is an urgent need to increase our understanding of TBI-induced long-term disability mechanisms related to chronic pain/headache, and to test the efficacy and mechanism of potential drug-free therapy, electro-acupuncture (EA), that has excellent potential for rapid translation. This urgently needed evidence-based testing of specific mechanisms of efficacy currently limit the application of this non- addictive drug-free EA therapy to TBI-induced pain/headache. This proposed study is designed in a rodent model of CH-TBI to provide a mechanism driven neurobiological basis for TBI- and EA therapy-induced changes in pain-and headache-like behaviors as they manifest by facial and somatic hypersensitivity/allodynia.

PI_NAMEs: HOU, JIAMEI  (contact)

PROJECT_TERMS: Absence of pain sensation;Acceleration;Acupuncture Therapy;Acute;Acute Pain;addiction;Adult;allodynia;Analgesics;Angiography;Apoptotic;Behavior;behavior test;Biological Markers;Blast Injuries;Blood - brain barrier anatomy;Blood Vessels;Blunt Trauma;Brain;chemokine;Chronic;Chronic Brain Injury;Chronic disability;Chronic Headaches;chronic pain;clinical translation;Clinical Trials;clinically relevant;Companions;Complication;Conflict (Psychology);Craniocerebral Trauma;Cutaneous;cytokine;Data;Dependence;design;Development;Diagnosis;Diffuse Axonal Injury;Dilatation - action;disability;Disease;Dose;effective therapy;Effectiveness;efficacy testing;Electric Stimulation;Electroacupuncture;Encephalopathies;Enzymes;Evaluation;Event;evidence base;Exhibits;Face;Functional Magnetic Resonance Imaging;Gender;Gene Expression;Genes;Head;head impact;Headache;healing;Health;Healthcare;Human;Human Resources;Hyperalgesia;Hypersensitivity;Immune;Immunohistochemistry;Inflammation;Inflammatory;inflammatory marker;Injury;injury and repair;innovation;interest;Intervention;Long term disability;Magnetic Resonance Imaging;Mechanics;Mediating;Medicine;Military Personnel;Modality;Modeling;multimodality;Neurobiology;neuroinflammation;Neuromodulator;neuronal excitability;neuronal survival;Neurons;neuroregulation;NF-kappa B;noradrenergic;novel;orofacial;Orofacial Pain;Outcome;Pain;pain reduction;pain sensitivity;pain signal;Painless;Pathway interactions;Patients;Permeability;Pharmaceutical Preparations;Placebo Control;Placebos;Post-Traumatic Headaches;pre-clinical;pre-clinical research;Preventive treatment;Procedures;Quality of life;Rattus;receptor;Receptor Signaling;Reperfusion Injury;Reporting;Research Personnel;response;Rewards;Risk Factors;Rodent Model;Sepsis;Signal Transduction;Signaling Molecule;Spinal Cord;Sports;Sprague-Dawley Rats;Stimulus;Surface;Symptoms;System;systemic inflammatory response;Tactile;targeted treatment;TBI treatment;Techniques;Testing;Therapeutic;Therapeutic Intervention;Therapeutic Uses;Time;Translations;Traumatic Brain Injury;treatment duration;Treatment Effectiveness;Trigeminal Nuclei;Trigeminal System;Up-Regulation;Vasodilator Agents;Vehicle crash;Veterans;War;Work

PROJECT_TITLE: A nonpharmacological therapeutic intervention of TBI-induced facial allodynia/hyperalgesias in a rodent model


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: BASIS RESEARCH INSTITUTE

ORG_STATE: NY

PHR: Project Narrative A core brain area responsible for memory is the hippocampus, which is impaired in a number of cognitive diseases, including Alzheimer’s. This work contributes to fundamental knowledge about the form of hippocampal representations, and their function in memory-guided cognitive behaviors. In order to address the question of how limits to hippocampal function might affect specific aspects of behavior, we compare memory-guided foraging behavior across animals with different hippocampus sizes, both in simulation and in natural environments.

PI_NAMEs: MACKEVICIUS, EMILY LAMBERT (contact)

PROGRAM_OFFICER_NAME: JOHNSON, KARI ANNE

PROJECT_TITLE: Influence of Hippocampus-Like Memory Representations on Decision Making in Foraging Birds


NIH_SPENDING_CATS: Biotechnology;Duchenne/ Becker Muscular Dystrophy;Muscular Dystrophy;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: CHICAGO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Neuromuscular disorders, including muscular dystrophy, are progressive muscle wasting disorders in which muscle is often replaced by fibrosis leading to reduced muscle function. We identified LTBP4 as a modifier of muscle disease and showed the protective forms of LTBP4 reduce fibrosis formation and delay disease progression in mice and humans with Duchenne muscular dystrophy. We are developing an anti-LTBP4 antibody as a biologic for the treatment of neuromuscular diseases.

PI_NAMEs: DEMONBREUN, ALEXIS R. (contact);MCNALLY, ELIZABETH M

PROGRAM_OFFICER_NAME: SHEPPARD, KELLY WILL

PROJECT_TERMS: absorption;Affinity;Animal Model;Antibodies;Antibody Therapy;Antibody-mediated protection;Binding;Biodistribution;Biological;Biological Assay;Biological Markers;Biological Response Modifier Therapy;boys;Breathing;candidate identification;Cell model;Cells;Chemicals;Chemistry;clinical candidate;Clinical Trials;cohort;congenital muscular dystrophy;Creatine Kinase;cross reactivity;cytotoxicity;Data;Defect;design;Development;Disease;Disease Progression;Dose;Drug Kinetics;Duchenne muscular dystrophy;Dystrophin;efficacy study;Enzyme-Linked Immunosorbent Assay;Excretory function;exon skipping;Fibrosis;Formulation;gene replacement therapy;gene therapy;Generations;Genes;Genetic;genetic variant;genome-wide;good laboratory practice;Growth;Heritability;Human;Hyperactivity;Impairment;improved;improved outcome;In Vitro;in vitro Assay;in vivo;Infiltration;Inherited;Injury;injury recovery;latent TGF-beta binding protein;Lead;lead optimization;Legal patent;Limb-Girdle Muscular Dystrophies;Link;Magnetic Resonance Imaging;manufacture;mdx mouse;Measures;Membrane;Metabolism;Modeling;mouse model;Mus;Muscle;Muscle function;muscle regeneration;Muscle Weakness;Muscular Atrophy;Muscular Dystrophies;Myopathy;Natural regeneration;neuromuscular;Neuromuscular Diseases;No-Observed-Adverse-Effect Level;nonhuman primate;Pathologic;Pathway interactions;Patients;Peptide Hydrolases;Performance;permanent cell line;pharmacodynamic biomarker;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Phase;pre-clinical;pre-Investigational New Drug meeting;preclinical study;Predisposition;Process;Production;protective effect;Proteins;Proteolysis;Qualifying;Recovery;Regulation;repaired;Research Contracts;Route;scale up;Scheme;Serum;Signal Transduction;standard of care;Steroids;success;Surrogate Markers;Therapeutic;Tissues;tool;Toxicokinetics;Toxicology;Transforming Growth Factor beta;Variant;Walking;Wasting Syndrome

PROJECT_TITLE: Development of anti-LTBP4 as a biologic to treat Neuromuscular Diseases

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders B Study Section[NSD-B]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Aging;Genetics;Human Genome

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: PROJECT NARRATIVE Despite active cell proliferation, differentiation and apoptosis, mammalian organs tightly maintain their overall size and function, indicative of a delicately balanced program that regulates cell population dynamics. This proposal aims to develop powerful single-cell genomic approaches that enable a whole-organismal view of single-cell spatiotemporal dynamics, and apply these methods to investigate how tissue homeostasis is maintained and disrupted during aging at single-cell resolution, thereby contributing to the knowledge of basic biology, as well as opening new therapeutic horizons for aging-related diseases.

PI_NAMEs: CAO, JUNYUE  (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Age;age group;Aging;aging process;aging related disease;Apoptosis;Architecture;Behavior;Biological;Biology;Cell Communication;Cell Proliferation;Cell Separation;cell type;Cells;Development;effective therapy;epigenome;experimental study;Extracellular Matrix;Extracellular Matrix Proteins;Genomic approach;Heterogeneity;Homeostasis;in vivo;Individual;Knowledge;life span;Location;Maintenance;Mammals;Maps;Measures;Methodology;Methods;Modeling;Molecular;Monitor;Mus;novel;novel therapeutics;old mice;Organ;Organism;Pathway interactions;Patients;Population Dynamics;programs;Proliferating;rational design;Resolution;single cell genomics;single-cell RNA sequencing;spatiotemporal;System;Techniques;Technology;Time;Tissues;transcriptome;transcriptomic profiling;Visualization;Whole Organism

PROJECT_TITLE: Single cell dynamics on a whole organism scale


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Physical Activity;Rehabilitation

ORG_CITY: Los Angeles

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PI_NAMEs: MATARIC, MAJA J (contact)

PROGRAM_OFFICER_NAME: BURSTEIN, MARCY ELLEN

PROJECT_TERMS: Adherence;Adult;Affect;aged;Anxiety;anxiety reduction;anxiety symptoms;Appearance;Auditory;autism spectrum disorder;Behavior;behavior change;Characteristics;Chronic stress;Client;Clinical;cognitive control;cognitive enhancement;Cognitive Therapy;Companions;comparison control;compliance behavior;Consumption;cost effective;COVID-19 pandemic;Cues;Data Analyses;Data Collection;design;Devices;Effectiveness;efficacy testing;Emotional;Enrollment;Evaluation;Evidence based intervention;Exercise;exercise adherence;Exercise Therapy;Feedback;Future;gaze;Goals;Health;high risk;Home;Human;Individual;innovation;Instruction;Intervention;Intuition;Learning Skill;Life;Long-Term Care for Elderly;Machine Learning;machine learning model;Mental disorders;Mental Health Associations;Methodology;Methods;Mission;Modeling;Mood Disorders;mood symptom;mortality;Motivation;Movement;multimodal modeling;National Institute of Mental Health;novel;Outcome;physical conditioning;Physical therapy;post intervention;preference;Principal Investigator;Problem Solving;programs;Public Health;Randomized;reduce symptoms;Reporting;Research;Resources;Robot;Sampling;sleep quality;social assistive robot;Social Change;social engagement;Social Interaction;social skills;Source;Stroke;student participation;Students;System;Techniques;therapy adherence;therapy outcome;Time;transfer learning;translational impact;Treatment Cost;Treatment Efficacy;Universities;university student;Validation;Visual;Voice;Well in self;Work;young adult

PROJECT_TITLE: SCH: Personalized AI-Driven Models for Supporting User Engagement and Adherence in Health Interventions: Validation in Cognitive Behavioral Therapy for Anxiety

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-N (50)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: PROJECT NARRATIVE Symptom relapse is quite common in the course of illness of schizophrenia, yet its pathophysiology has not been well captured in most previous research, as few studies account for the common confounder of treatment non-adherence. In this proposal, we aim to study brain functioning in individuals treated with long acting injectable antipsychotics at the time of relapse, for whom medication delivery can be confirmed. The results from this study will generate knowledge about the essential brain mechanisms of psychosis relapse despite confirmed medication delivery.

PI_NAMEs: RUBIO, JOSE M (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Address;Adherence;Affect;Antipsychotic Agents;Automobile Driving;Belief;Biological Markers;Brain;Clinical;Corpus striatum structure;Data;design;Dopamine;experience;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Health Care Costs;Hospitalization;improved;indexing;Individual;Injectable;innovation;Inpatients;Knowledge;Literature;Magnetic Resonance Imaging;Measures;Mediating;medication compliance;neurobiological mechanism;neuromelanin;novel strategies;Occupational;Patients;Pharmaceutical Preparations;Play;Prognostic Marker;Psychoses;Psychotic Disorders;Quality of life;Recurrence;Relapse;relapse prevention;Research;response;Rest;reward processing;Rewards;Role;Schizophrenia;Social Functioning;Symptoms;Testing;Time;transmission process;treatment adherence;treatment response

PROJECT_TITLE: Striatal Function in Psychosis Relapse

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The purpose of this Training Grant is to prepare qualified postdoctoral trainees in Endocrinology, Diabetes and Metabolism for scientific research careers that significantly impact on the health-related research needs of the United States. This training program will utilize Stanford University’s world-class faculty and resources in the fields of basic, translational and population health research in endocrinology with a primary focus on diabetes. Trainees who graduate from this program will be well-prepared to independently lead (within an academic or industrial setting), create and apply new scientific discoveries that enhance public health in areas of diabetes, obesity, bone health and hormone-dependent cancer.

PI_NAMEs: ANNES, JUSTIN PIERCE (contact);MAAHS, DAVID MATTHEW

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TITLE: Diabetes, Endocrinology and Metabolism Training Grant

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Heart Disease - Coronary Heart Disease;Neurosciences

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: Narrative Catheter ablation of ventricular tachycardia in ischemic heart disease has suboptimal results. We will test the value of supplemental ablation via ethanol infusion in the infarct-related vein in improving ablation outcomes in a randomized trial. We will study the impact of the VT substrate characteristics and innervation -shown by multi-modality imaging- on the outcome of catheter ablation

PI_NAMEs: VALDERRABANO, MIGUEL  (contact)

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: Ablation;Adhesions;Adrenergic Agents;Anatomy;Angiography;Area;Arteries;Atherosclerosis;Authorization documentation;Cannulations;Cardiac;Cardiac ablation;cardiac magnetic resonance imaging;Cardiomyopathies;Case Study;Catheterization;Characteristics;Cicatrix;Circulation;Clinical;clinical efficacy;clinical trial protocol;Clinical Trials;Collection;Contracts;Coronary;Coronary artery;Coronary sinus structure;Coronary Vessels;Data;Denervation;design;Embryology;Enrollment;Ethanol;experience;Fatty acid glycerol esters;Future;Goals;Heart;Hypersensitivity;Image;improved;Infarction;Infusion procedures;injured;insight;Investigational Drugs;Ischemia;ischemic cardiomyopathy;Left;Lesion;Magnetic Resonance;Manuals;Maps;Multimodal Imaging;Myocardial;Myocardial Infarction;Myocardial Ischemia;Myocardium;Nerve;nerve supply;operation;Outcome;Patients;Pericardial body location;Phase;Play;Positron-Emission Tomography;Procedures;Protocols documentation;radio frequency;Radiofrequency Interstitial Ablation;Randomized;randomized trial;randomized, clinical trials;Refractory;Registries;Research Personnel;Risk;Role;Route;Safety;Site;structural determinants;Structure;Structure of left gastric vein;Structure of phrenic nerve;success;Techniques;Testing;Therapeutic;Therapeutic Effect;Tracer;Veins;Venous;Ventricular;Ventricular Arrhythmia;Ventricular Premature Complexes;Ventricular Tachycardia;Work

PROJECT_TITLE: VENOUS ETHANOL ABLATION IN ISCHEMIC VENTRICULAR TACHYCARDIA- VELVET TRIAL

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(JA)]


NIH_SPENDING_CATS: Digestive Diseases;Nutrition

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project narrative There is a need for scientists who appreciate the clinical challenges of patients with digestive diseases and then seek to understand the mechanisms of disease. This research training program will provide a high-quality mentored training experience in basic, translational or clinical research. The fellows trained in this program will be prepared for meaningful careers in research that will ultimately lead to new diagnostic tests and therapies for patients with digestive diseases.

PI_NAMEs: LIDDLE, RODGER A.;MUIR, ANDREW J. (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TITLE: Duke Training Grant in Digestive Diseases and Nutrition


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;HIV/AIDS;Immunotherapy;Infectious Diseases;Liver Cancer;Liver Disease;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PI_NAMEs: OWONIKOKO, TAOFEEK K (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: Affect;AIDS related cancer;antiretroviral therapy;Biological Assay;Cancer Patient;CD8-Positive T-Lymphocytes;Cell Communication;Cells;Cessation of life;checkpoint therapy;Clinical Research;Color;Cytometry;Dendritic Cells;epigenomics;exhaust;exhaustion;experience;Foundations;Future;gene network;General Population;Genes;Goals;Growth;HIV;HIV Infections;Human;humanized mouse;Image;Immune;Immune checkpoint inhibitor;immune resistance;Immune Targeting;Immunosuppression;Immunotherapeutic agent;Immunotherapy;Impairment;improved outcome;Infiltration;Inflammation;Interferons;Lead;Liver diseases;Liver neoplasms;Lymphoid Tissue;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant Neoplasms;metabolomics;mouse model;multiple omics;Mus;Non-Small-Cell Lung Carcinoma;novel therapeutic intervention;novel therapeutics;Outcome;Pathogenicity;Pathway interactions;Persons;Preclinical Testing;Primary carcinoma of the liver cells;programmed cell death protein 1;programs;Regulatory T-Lymphocyte;Risk;Spleen;stem;T-Lymphocyte;Testing;Time;transcriptomics;tumor;tumor growth;tumor microenvironment;Tumor Promotion;Tumor Tissue;tumor-immune system interactions

PROJECT_TITLE: Tumor-associated pDC (TApDC) and HIV infection in programing tumor microenvironment

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Biotechnology;Charcot-Marie-Tooth Disease;Genetics;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Rare Diseases

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: Charcot-Marie-Tooth disease affects approximately 1:2500 people and the largest family of genes associated with this disorder is the tRNA-synthetases. How mutations in these ubiquitous genes lead to the degeneration of specific nerves is unknown. We are exploring the biochemical and cell biological basis of these disorders using mice and human cell lines engineered to model patient mutations; this work will also test both pharmacological and gene therapy treatment strategies.

PI_NAMEs: BURGESS, ROBERT W. (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: adeno-associated virus 9 delivery;Affect;Afferent Neurons;Affinity;Agreement;Alleles;Amino Acids;Amino Acyl-tRNA Synthetases;Award;Biochemical;Biochemistry;Biological;biological adaptation to stress;Cell Differentiation process;cell type;Cells;Cellular biology;Charcot-Marie-Tooth Disease;Charge;Chronic;Clinical;Code;Codon Nucleotides;Collaborations;Collection;Data;Development;Disease;disease model;DNA cassette;dominant genetic mutation;Down-Regulation;EEF1A1 gene;Engineering;Enzymes;experimental study;Funding;Future;Gene Family;gene therapy;Genes;Genetic;Genetic study;Germ Lines;Glycine-Specific tRNA;Goals;Health Sciences;Hereditary Disease;Human;Human Cell Line;human induced pluripotent stem cells;in vivo;inducible Cre;industry partner;Inherited;inhibitor;Kinetics;Knockout Mice;Lead;Ligase;Measures;Modeling;Molecular Genetics;Motor Neurons;Mouse Cell Line;mouse model;Mus;mutant;Mutation;Nerve;Neurodegenerative Disorders;Neuromuscular Junction;Neuropathy;novel;Outcome;overexpression;Pathogenicity;Patients;Peripheral Nervous System Diseases;Persons;pharmacologic;Phenotype;Phosphotransferases;preclinical development;Predisposition;prevent;Progress Reports;Reaction;Research;Ribosomes;Severities;Severity of illness;Site;Specificity;System;Testing;Therapeutic;Transfer RNA;Transfer RNA Aminoacylation;Transgenes;Transgenic Organisms;translational potential;Translations;treatment strategy;Tyrosine-Specific tRNA;Tyrosine-tRNA Ligase;Up-Regulation;Validation;Variant;vector;Work

PROJECT_TITLE: The Genetics of the Neuromuscular Junction: Mechanisms and Disease Models


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Hematology;Hodgkin's Disease;Infectious Diseases;Lung;Lymphatic Research;Lymphoma;Orphan Drug;Pneumonia;Pneumonia and Influenza;Prevention;Rare Diseases;Tuberculosis

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Delayed diagnosis and early mortality from Hodgkin lymphoma in people living with HIV (PWH) in South Africa is an emerging public health crisis. Marked elevations in ferritin might identify patients for early diagnosis and aid in the management of Hodgkin lymphoma in a low-resource setting. Our overarching goal is to show that extreme elevations in ferritin, that do not respond to initial treatment regimens (i.e antibiotics or TB therapy), should raise the suspicion of Hodgkin lymphoma in PWH.

PI_NAMEs: NELSON, WILLIAM GEORGE (contact)

PROJECT_TERMS: Address;Admission activity;Adult;AIDS-Related Hodgkin's Lymphoma;AIDS-Related Lymphoma;Anemia;Antibiotic Therapy;Biological Assay;Biological Markers;biomarker development;Bone Marrow Involvement;chemotherapy;Clinical;Clinical Data;Clinical Trials;co-infection;cohort;Cohort Studies;community acquired pneumonia;comparative;cost;cytokine;cytopenia;Data;Development;Diagnosis;Diagnostic tests;Disease;early detection biomarkers;Early Diagnosis;Enrollment;Epstein Barr Virus associated tumor;Ferritin;follow-up;Frequencies;Funding;Future;Goals;Hematology;Hemophagocytic Lymphohistiocytoses;high risk;HIV;HIV Seronegativity;HIV/AIDS;HIV/TB;Hodgkin Disease;Hospitals;Human Herpesvirus 4;Hypoalbuminemia;immunosuppressed;immunotherapy clinical trials;immunotherapy trials;implementation barriers;improved;In complete remission;Incidence;indexing;Industry;inflammatory marker;inflammatory milieu;inhibitor;International;Lymphoma;Lymphopenia;Marrow;molecular marker;Morbidity - disease rate;mortality;Non-Hodgkin's Lymphoma;Oncology;Outcome;Participant;participant enrollment;Pathologic;Patients;Performance Status;Persons;Plasma;Pneumonia;Population;Prognosis;prognostic;Prognostic Factor;prognostic significance;prognostic value;prospective;Public Health;Rapid diagnostics;Research;Research Priority;Resource-limited setting;response;Role;screening;Serum;South Africa;Specimen;Time;Treatment Protocols;treatment risk;Tuberculosis;tuberculosis treatment;tumor;tumor DNA;United States National Institutes of Health;Viral;Viral Load result;Viremia

PROJECT_TITLE: Regional Oncology Research Center (Stimulate Research in HIV/AIDS Supplement)


ADMINISTERING_IC: DC

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Epilepsy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Pediatric

ORG_CITY: PITTSBURGH

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE This research aims to characterize how the functional map of the left or right cerebral hemisphere can change to accommodate a cognitive function that is ordinarily lateralized to the opposite cerebral hemisphere, when the opposite cerebral hemisphere is damaged early in life. This investigation is especially important for language processing, which is typically supported in the left hemisphere and is resistant to reorganizing into the right hemisphere after left hemisphere injury in adulthood. By examining how functions can reorganize after the onset of seizures and then the surgical removal of part of one cerebral hemisphere during childhood, we can advance fundamental knowledge about how cognitive functions become mapped to cortical regions, and how this mapping can be amended in the presence of disruption and damage to the system.

PI_NAMEs: MARTIN, KELLY C (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Adult;advanced analytics;Age;Amendment;analytical tool;Area;artificial neural network;Auditory;Bilateral;Brain;career;Cerebral hemisphere;Child;Childhood;childhood epilepsy;Chronic;Clinical;Clinical Trials;cognitive function;cognitive neuroscience;cognitive process;Computer Models;course development;Cross-Sectional Studies;data modeling;deep neural network;design;Development;developmental plasticity;Dimensions;Disease;Emotional;Event;Excision;Fellowship;Functional Magnetic Resonance Imaging;Future;Goals;hemisphere damage;Hemispherectomy;imaging study;Individual;infancy;Infant;Injury;Institution;Intervention;Intractable Epilepsy;Investigation;Knowledge;Language;language impairment;language processing;Learning;Left;Lesion;Life;Lobectomy;Longitudinal Studies;Maps;Measures;Mentorship;Methods;Modeling;Multivariate Analysis;Nature;nerve injury;neural;neural correlate;Neurocognitive;neuroimaging;neuronal patterning;Neurons;Operative Surgical Procedures;Outcome;Participant;Pattern;Persons;Population;post stroke;preservation;prevent;Recovery;Recovery of Function;recruit;Research;Research Personnel;Resected;Resistance;Resources;Right cerebral hemisphere;Running;Seizures;Side;simulation;skills;Stimulus;Stroke;Structure-Activity Relationship;System;Testing;Theoretical model;Time;timeline;Tissues;tool;Training;Training Activity;Universities;Weight;Work

PROJECT_TITLE: Language plasticity after childhood hemispherectomy: Neuroimaging and computational modeling

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-N (36)]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Aging;Contraception/Reproduction;Endocrine Disruptors;Infertility;Women's Health Research

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: This work will greatly improve our understanding about how phthalates cause early reproductive aging in females. In turn, this work will set the foundation for the identification and development of novel targets for the treatment of phthalate-induced diseases, including early reproductive aging.

PI_NAMEs: FLAWS, JODI A. (contact);NOWAK, ROMANA A.;RAETZMAN, LORI T

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Acceleration;Acute;Adhesives;Adult;Age;Aging;angiogenesis;antagonist;Anti-Inflammatory Agents;Aryl Hydrocarbon Receptor;B-Lymphocytes;Binding;Biological Assay;cardiovascular disorder risk;CD4 Positive T Lymphocytes;Cell Aging;Cell Count;Cells;Cessation of life;Characteristics;Childbirth;Chronic;consumer product;Curcumin;cytokine;Data;Defoaming Agents;Delayed Childbearing;Development;diminished ovarian reserve;Disadvantaged;Disease;Dose;early experience;early onset;Endocrine Disruptors;Environment;environmental chemical;epidemiology study;experience;exposed human population;Exposure to;Female;female reproductive system;Fertility;Fibrosis;Follicle Stimulating Hormone;Foundations;Gene Expression;Gene Expression Profiling;Greater sac of peritoneum;Growth;Health;Hormones;human tissue;Hypothalamic structure;IL8 gene;Immune;Immunohistochemistry;improved;Infertility;Inflammasome;Inflammation;Inflammatory;inhibin B;Interferon Type II;Interleukin-10;Interleukin-6;ITGAM gene;KISS1 gene;Lubricants;Macrophage;Medical Device;men;Menopausal Symptom;Mental Depression;mono-(2-ethylhexyl)phthalate;Mus;Natural Killer Cells;novel;Osteoporosis;Ovarian Follicle;Ovary;Pathway interactions;Peritoneal Macrophages;personal care products;Pesticides;phthalates;Physiological;Pituitary Gland;Play;Population;Premature Menopause;Proliferating;protein expression;Public Health;Publishing;RANTES;Reporter;Reproduction;reproductive;Reproductive Health;reproductive longevity;reproductive senescence;Risk;Role;Serum;Signal Pathway;Solvents;subfertility;System;T-Lymphocyte;Testing;Time;Tissues;TNF gene;Uterus;Woman;Women's Health;Wood material;Work

PROJECT_TITLE: Phthalate Exposure and Female Reproductive Aging


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD)

ORG_CITY: MENLO PARK

ORG_NAME: MARTINEAU & ASSOCIATES

PHR: Project Narrative  Innovation in zebrafish welfare needs to keep up with the increasing use of this animal model of human disease for impactful medical research. Using a revolutionary imaging technology called Remanent Imaging, the proposed “CanaryTank” system will directly plug into existing husbandry facilities and video monitor the behavior of sentinel fish populations to detect threats to their health and wellbeing. By monitoring a wide range of crucial factors neglected by current systems, CanaryTank will realize a giant leap forward in securing the health and wellbeing of medical research zebrafish, a paramount concern and unmet need as the rigor and repeatability of research depends on them.

PI_NAMEs: MARTINEAU, PIERRE R. (contact)

PROGRAM_OFFICER_NAME: DURKIN, JACLYN MARIE

PROJECT_TERMS: 3-Dimensional;Adopted;Animal Model;Anxiety;Behavior;behavior change;Behavior monitoring;Behavioral;Classification;Code;Collection;commercialization;Communities;Complex;Computer Vision Systems;dashboard;Data;design;Detection;diagnostic algorithm;Electronic Mail;Event;experimental study;feeding;Fishes;Funding;Future;Health;Health system;human disease;human model;Hunger;Image;Imaging technology;improved;innovation;Light;Machine Learning;Measures;Medical Research;millisecond;Mind;Monitor;Movement;Names;neglect;Personal Satisfaction;Phase;Plug-in;Population;Process;prototype;Reporting;Research;Research Project Grants;Secure;Sentinel;Sleep;success;Swimming;System;Techniques;Technology;temporal measurement;Time;United States National Institutes of Health;Vision;water quality;welfare;Zebrafish

PROJECT_TITLE: CanaryTank: a plug-in husbandry behavior tracking system for health of fish facilities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(13)-B]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Schizophrenia

ORG_CITY: Chicago

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: Project Narrative Metabotropic glutamate receptors (mGluRs) are central regulators of glutamate signaling in the brain and are currently considered key drug targets for neurological disorders such as autism, anxiety, schizophrenia, Parkinson’s disease, and addiction. The proposed research will apply cutting-edge methodologies that will allow us to directly watch receptors as they interact with ligands and function, to learn about how they function, with unprecedented accuracy. This knowledge may hold the key for the development of effective therapeutics for difficult-to-treat human diseases.

PI_NAMEs: VAFABAKHSH, REZA  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: addiction;Affect;Anxiety;Architecture;autism spectrum disorder;Biochemical;Biophysics;Brain;Cholesterol;Computing Methodologies;Development;Drug Targeting;Epilepsy;Family;Fragile X Syndrome;G-Protein-Coupled Receptors;glutamatergic signaling;Human;human disease;In Vitro;insight;Knowledge;Learning;Ligands;live cell imaging;Malignant Neoplasms;Marketing;member;Membrane;Membrane Proteins;Metabotropic Glutamate Receptors;Methodology;Methods;Modeling;Molecular Conformation;Motion;multidisciplinary;Nervous System Disorder;new technology;Parkinson Disease;Pattern;Pharmaceutical Preparations;Physiological;Protein Conformation;Protein Dynamics;Protein Engineering;rational design;receptor;Receptor Activation;Receptor Signaling;Research;Resolution;Role;Schizophrenia;Shapes;side effect;Signal Pathway;Signal Transduction;single-molecule FRET;Spectrum Analysis;Structure;therapeutically effective;Time;Tissues

PROJECT_TITLE: Quantitative analysis of metabotropic glutamate receptor activation and modulation

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

ORG_CITY: SAN DIEGO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: Project Narrative Prenatal alcohol exposure can result in numerous adverse effects impacting almost every bodily system affecting day-to-day functioning, making it an international public health, educational, economic, and social concern. The International Conferences on Fetal Alcohol Spectrum Disorders (FASD), previously hosted by University of British Columbia in Vancouver, Canada and now convening in Seattle, WA under the auspices of FASD United are unique in bringing together basic and clinical researchers with professionals in all aspects of the FASD field and the FASD community as the voice of “living experience.” This grant will: a) provide partial travel and registration support to increase the attendance of US junior investigators and non-US investigators from underrepresented countries with developing alcohol research programs allowing scientific exchange that will advance knowledge, support new and ongoing collaborations, and ultimately influence policy and practice in the FASD field; and b) assist with the broad dissemination of conference content.

PI_NAMEs: RILEY, EDWARD P (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: addiction;Administrator;Adolescent;Adult;Adverse effects;Affect;alcohol research;Alcohols;Archives;autism spectrum disorder;Awareness;Body System;British Columbia;Canada;career;Caregivers;Child Welfare;Clinical;Clinical Research;Collaborations;Communities;Continuing Education;Country;Cultural Backgrounds;Diagnosis;Discipline;Disease;Down's Syndrome;Economics;Education;Electronic Mail;Environment;Epidemiology;Ethnic Origin;European;experience;Exposure to;Family;Family member;Feedback;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fetal Alcohol Syndrome;forging;Funding;Future;Grant;improved;Individual;Information Dissemination;interest;International;Intervention;Justice;Knowledge;Laboratories;Laboratory Study;lens;meetings;member;Mental Health;Mission;Newsletter;outreach;Pamphlets;pandemic disease;Participant;Persons;physical conditioning;Physicians;Policies;Policy Maker;Prevalence;Prevention;Primary Prevention;programs;Public Health;Research;Research Personnel;Resources;Rural;Scientist;service providers;Shapes;Slide;social;social media;South American;Specialist;Students;symposium;Travel;Universities;Update;virtual;Vision;Voice;web site;webinar;Woman;Work

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The proposed mechanistic trial will utilize mindfulness training to permit examination of questions about the causal role of emotion regulation strategies linked to the striving persistent behavioral style in driving mental health and health morbidities among BIPOC78. The proposed Project STRIVE (STudents RIsing aboVE) will identify BIPOC students who are academically resilient in the face of disadvantage and will offer a tailored mindfulness intervention targeting self-regulation processes as a putative mechanism to interrupt the links between the striving persistent behavioral style and negative health outcomes. We propose a multisite randomized trial to the effects of the STRIVE intervention on putative self-regulation mechanisms, health and mental health outcomes, and to examine the mechanistic model linking striving persistent behavioral style to health and mental health morbidities.

PI_NAMEs: LAU, ANNA SHAN-LAI (contact)

PROGRAM_OFFICER_NAME: ROONEY, MARY

PROJECT_TERMS: Academic achievement;Academic skills;Achievement;Adolescent;Aftercare;allostatic load;Anxiety;anxiety symptoms;Asian Americans;attentional control;Automobile Driving;Behavioral;Biological;Biological Markers;Black race;Black, Indigenous, People of Color;Blood Pressure;Body mass index;Cardiovascular Diseases;Cardiovascular system;children of color;Chronic stress;college;Color;Complex;cost;depressive symptoms;Development;Disadvantaged;early life adversity;early life stress;Educational Curriculum;Eligibility Determination;emotion regulation;Emotions;Enrollment;ethnic minority;examination questions;Exhibits;experience;externalizing behavior;First Generation College Students;Health;Health Care Costs;health disparity;Hip region structure;Hydrocortisone;inclusion criteria;indexing;Informal Social Control;Institutional Racism;Interruption;Intervention;intervention effect;Latinx;Link;marginalized community;Mediating;Mediator;Mental Health;Metabolic;Metabolic syndrome;mindfulness intervention;Mindfulness Training;mindfulness-based stress reduction;minority children;minority student;Modeling;Morbidity - disease rate;Neck;Neurosecretory Systems;Outcome;physical conditioning;Physiological;Population;Poverty;prevent;Prevention trial;preventive intervention;Problem behavior;Process;Public Participation;Qualifying;Race;Randomized;randomized trial;Research;resilience;Resources;Risk;Role;Schools;Secondary Schools;Site;skills;social capital;Socialization;socioeconomic disadvantage;Students;Study Skills;success;Symptoms;Testing;therapy design;Youth

PROJECT_TITLE: Project STRIVE (STudents RIsing above) - Offsetting the health and mental health costs of resilience

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Caregiving Research;Clinical Research;Disability Research;Hearing Loss;Neurosciences;Pediatric

ORG_CITY: WASHINGTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: GALLAUDET UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative Caregivers of deaf/hard-of-hearing (DHH) may want to provide sign exposure to protect their child from linguistic deprivation but have to learn how to sign in order to do so. Adults have developed their embodied cognition skills – the ability to use stored sensory-motoric experiences during tasks – and may be able to capitalize on these skills when learning to sign, particularly for signs that directly access these stored representations. This proposal aims to assess the impact of motoric-iconicity–the structured mapping between a sign’s form (shape/movement) and its meaning–on embodied cognition in native signers and adult sign learners to determine if these signs can serve as a starting point for caregiver-centric interventions.

PI_NAMEs: MCGARRY, MEGHAN ELIZABETH (contact)

PROJECT_TITLE: Examining Iconicity with EEG: The role of Motoric Iconicity and Embodied Cognition in American Sign Language


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PI_NAMEs: HENSLEY, SCOTT  (contact)

PROJECT_TERMS: Animals;Basic Science;Cohort Studies;cross immunity;Development;Disease Outcome;Environmental Risk Factor;Evolution;Human;Immune;Immune response;Immunologic Factors;improved;Influenza;influenza infection;Influenza vaccination;influenzavirus;Molecular;National Institute of Allergy and Infectious Disease;Pathogenicity;Research;response;Sampling;transmission process;Vaccination

PROJECT_TITLE: NIAID Centers of Excellence for Influenza Research and Response


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

PROJECT_TERMS: Animals;Basic Science;Cohort Studies;cross immunity;Disease Outcome;Environmental Risk Factor;Evolution;Human;Immune;Immune response;Immunologic Factors;improved;Influenza;influenza infection;Influenza vaccination;influenzavirus;Molecular;National Institute of Allergy and Infectious Disease;Pathogenicity;Research;Research Activity;response;Sampling;transmission process;universal influenza vaccine;Vaccination;vaccine development;Vaccine Research

PROJECT_TITLE: NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

PROJECT_TERMS: 2019-nCoV;Animals;Basic Science;Cohort Studies;Coronavirus;cross immunity;diagnostic development;Diagnostics Research;Disease Outcome;Environmental Risk Factor;Evolution;Human;Immune;Immune response;Immunologic Factors;improved;Infection;Molecular;Pathogenicity;Research Activity;respiratory virus;response;Sampling;transmission process;Vaccination;Virus

PROJECT_TITLE: CEIRR: SARS-CoV-2 Research Activities


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PI_NAMEs: LOWEN, ANICE  (contact)


PROJECT_TERMS: Animals;Basic Science;Cohort Studies;cross immunity;Development;Disease Outcome;Environmental Risk Factor;Evolution;Human;Immune;Immune response;Immunologic Factors;improved;Influenza;influenza infection;Influenza vaccination;influenzavirus;Molecular;National Institute of Allergy and Infectious Disease;Pathogenicity;Research;Research Activity;response;Sampling;transmission process;universal influenza vaccine;Vaccination


ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PI_NAMEs: WEBBY, RICHARD  (contact)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

PROJECT_TERMS: 2019-nCoV;Animals;Cohort Studies;Coronavirus;COVID-19 vaccine;cross immunity;Disease Outcome;Environmental Risk Factor;Evolution;Human;Immune;Immune response;Immunologic Factors;improved;Infection;Molecular;Pathogenicity;Research Activity;respiratory virus;response;Sampling;transmission process;Vaccination;vaccine development;Virus


PROJECT_TERMS: Animals;Basic Science;Cohort Studies;cross immunity;Disease Outcome;Environmental Risk Factor;Evolution;Human;Immune;Immune response;Immunologic Factors;improved;Influenza;influenza infection;Influenza vaccination;influenzavirus;Molecular;National Institute of Allergy and Infectious Disease;Pathogenicity;Research;response;Sampling;transmission process;universal influenza vaccine;Vaccination

PROJECT_TITLE: NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE: UNIVERSAL INFLUENZA RESEARCH


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Services;Methamphetamine;Opioid Misuse and Addiction;Opioids;Prevention;Primary Health Care;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: HANOI

ORG_COUNTRY: VIETNAM

ORG_FIPS: VM

ORG_NAME: HANOI MEDICAL UNIVERSITY

PHR: Project narrative We propose to build upon the STAR-OM study (R01 DA050486) to assess the feasibility and acceptability of behavioral treatment and challenges of medication treatment for people with primary methamphetamine use disorder and without opioid use disorder at methadone clinics in Hanoi, Vietnam. Expanding treatment options at methadone clinics to provide evidence-based interventions to people with primary methamphetamine use disorder would be a cost-effective strategy to increase treatment coverage for this population. The study will provide preliminary data for prospectively assessing effectiveness and implementation barriers of the interventions.

PI_NAMEs: LE, GIANG M (contact);SHOPTAW, STEVEN J

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: acceptability and feasibility;adaptive intervention;addiction;Adherence;Agreement;arm;authority;Behavior Therapy;Bupropion;care seeking;Cities;Clinic;community based treatment;comorbidity;Consent;contingency management;cost;cost effective;cost effectiveness;craving;Data;Drug Prescriptions;Drug Screening;Education;effective therapy;effectiveness evaluation;Eligibility Determination;Enrollment;evidence base;Evidence based intervention;Focus Groups;Goals;Government;Health care facility;Hospitals;Human Resources;implementation barriers;implementation evaluation;improved;Individual;Intervention;Intervention Studies;Interview;medication for opioid use disorder;Methadone;methadone clinic/center;methadone treatment;Methamphetamine;methamphetamine use;Methamphetamine use disorder;Mirtazapine;Monitor;Nurses;opioid use disorder;outreach;Participant;participant enrollment;Patient Recruitments;Patients;peer;Persons;Pharmaceutical Preparations;Physicians;Policy Maker;Population;post intervention;Primary Care;prospective;Provider;Questionnaires;Randomized;Readiness;recruit;Resources;retention rate;Sampling;scale up;screening;Shapes;social media;Stigmatization;Substance Use Disorder;Suggestion;supplemental instruction;Testing;Training;treatment arm;treatment services;United States National Institutes of Health;Urine;Vietnam;Visit;Withdrawal Symptom

PROJECT_TITLE: Screen, Treat and Retain People with Primary Meth Use Disorder at MMT Clinics (STAR-OM+)


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse

ORG_CITY: Lake Forest

ORG_NAME: REKOVAR INC.

ORG_STATE: CA

PHR: PROJECT NARRATIVE Rekovar is developing a low-cost wearable monitoring system that integrates wirelessly with a mobile device to allow real- time monitoring of the baby’s physical and physiological state and its ability to sleep, eat, and be nurtured while undergoing neonatal abstinence syndrome (NAS). This device has significant impact in helping reduce both hospital stay and costs as neonates receiving pharmacological treatment are usually in the NICU away from family and non- pharmacological care. Our interest lies with respect to proper neonatal care, where separate procedures occur for essential neonatal needs and needs for neonates undergoing withdrawal, and by using this monitoring device to assess addicted neonates undergoing withdrawal, caregivers are provided the better ability of treating the right neonatal needs with the appropriate procedure in hospitals.

PI_NAMEs: AL FARUQUE, MOHAMMAD ABDULLAH;SHARAREH, SHIVA  (contact);TSENG, PETER

PROGRAM_OFFICER_NAME: ANGELONE, LEONARDO MARIA

PROJECT_TERMS: Algorithms;artificial intelligence algorithm;behavior measurement;Biosensor;Birth;care costs;Caregivers;Caring;Charge;Clinical;clinical development;Clinical Trials;Computer software;cost;Data;Data Collection;Decision Making;Detection;Development;Devices;Diagnosis;Diagnostic;digital;digital assessment;Docking;Drug Interactions;Eating;efficacy evaluation;encryption;Ensure;Family;graphical user interface;handheld mobile device;Health Professional;Healthcare;Hospital Costs;Hospitals;Image;imaging properties;improved;Infant;innovation;Institutional Review Boards;interest;Intervention;Length of Stay;Marketing;Medical Care Costs;Methods;Monitor;monitoring device;Neonatal;Neonatal Abstinence Syndrome;neonatal care;neonatal health;Neonatal Intensive Care Units;neonatal patient;neonate;Newborn Infant;opioid exposure;opioid withdrawal;Patients;Performance;Pharmaceutical Preparations;Pharmacological Treatment;Phase;Physiological;portability;Positioning Attribute;prenatal exposure;Procedures;real time monitoring;Reporting;Risk;Safety;Severities;Sleep;Substance Withdrawal Syndrome;success;Symptoms;System;Tablets;Technology;tool;Toxic effect;treatment response;treatment risk;user-friendly;Validation;wearable device;wearable monitor;wireless;Withdrawal;Work;wristband

PROJECT_TITLE: Wireless withdrawal detection and monitoring system for neonatal abstinence syndrome.


NIH_SPENDING_CATS: Aging;Cancer;Genetics;Lung;Lung Cancer;Prevention;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BOSTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Progenitor cell states contributing to aging and lung cancer Narrative Aging is a primary risk factor for lung cancer, which accounts for the largest cause of cancer deaths. Cells in the lung alveoli are the source of the most common lung cancers and slowly become less functional as they age. We will use new models to investigate how molecular changes in alveolar cells contribute to cancer initiation during aging.

PI_NAMEs: HAIGIS, MARCIA  (contact);KIM, CARLA F.

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Adult;Age;age effect;age related;age related changes;aged;Aging;Alveolar;Alveolar Cell;alveolar epithelium;alveolar type II cell;Cancer Etiology;cancer initiation;cell age;Cell Aging;Cell model;Cells;Cessation of life;Cholesterol;Chromatin;Colorectal Cancer;Data;Disease;Distal;Epigenetic Process;Epithelial Cells;experience;Functional disorder;Gene Expression;Genes;Genetically Engineered Mouse;Growth;hallmarks of aging;Homeostasis;Human;Image;Impairment;in vivo Model;injury and repair;insight;Intervention;Link;Lipids;Lung;Lung Adenocarcinoma;lung cancer cell;lung development;Lung Diseases;lung injury;Lung Neoplasms;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;mass spectrometric imaging;Mass Spectrum Analysis;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolome;metabolomics;Methyltransferase;Modeling;Modification;Molecular;molecular modeling;mortality;mouse model;Mus;Natural regeneration;novel;Organoids;Pathway interactions;Persons;Population;Predisposition;prevent;Process;progenitor;Pulmonary alveolar structure;Regulation;Reporting;Resolution;Respiratory physiology;Risk Factors;Role;self renewing cell;single cell sequencing;Smoking;Source;stem cell biology;stem cell function;stem cells;Steroids;Study models;synergism;System;Technology;Testing;tumor;tumor initiation;tumor metabolism;tumor progression;tumorigenesis


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: PROJECT NARRATIVE Infantile rhabdomyosarcoma (RMS) is a newly identified and poorly understood aggressive pediatric muscle cancer that affects young children. There is one single mutation that causes the disease, but we do not have specialized treatments targeting this genetic event, and patients are treated with general strategies that are often ineffective or have harsh life-long side effects. We will leverage novel zebrafish and mouse cancer models to help young children with cancer by understanding the biology of how infantile RMS develops and implementing these models to identify clinically tractable therapeutic targets.

PI_NAMEs: KENDALL, GENEVIEVE CLAIRE (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Actins;Address;ADP-ribosylation factor 6;Affect;Allografting;Alveolar Rhabdomyosarcoma;Animal Model;Animals;Binding;Biochemical;Biology;Cancer Biology;Cancer Model;Cell Culture Techniques;Cell Line;Cell Lineage;Cells;chemotherapy;Child;Childhood;Chromatin;Classification;Clinical;clinical care;clinical sequencing;comparative;Complex;Data;Development;Developmental Biology;Developmental Gene;Disease;druggable target;Embryonal Rhabdomyosarcoma;Endocytic Vesicle;Event;FOXO1A gene;Gene Expression Profile;Gene Fusion;Genetic;Genetic Diseases;Genetic Transcription;Genomics;Goals;Human;human disease;infancy;innovation;Knock-out;Knowledge;Malignant Childhood Neoplasm;malignant muscle neoplasm;Malignant Neoplasms;Maps;Mediating;Modeling;Molecular;Monomeric GTP-Binding Proteins;Mus;Muscle;Muscle Development;mutant;Mutation;Myoblasts;myogenesis;NCOA2 gene;novel;novel therapeutic intervention;Nuclear Receptors;Oncogenes;Oncogenic;Oncology;Operative Surgical Procedures;overexpression;Pathway interactions;patient derived xenograft model;Patients;PAX3 gene;Predisposition;progenitor;programs;Property;Radiation;Research;Rhabdomyosarcoma;Role;Sampling;Series;side effect;Skeletal Muscle;small molecule;spatiotemporal;Structure;System;targeted treatment;Tertiary Protein Structure;Testing;Therapeutic;therapeutic target;Transcription Coactivator;transcription factor;Transgenic Organisms;tumor;tumor initiation;tumorigenesis;tumorigenic;Validation;Zebrafish;zebrafish development

PROJECT_TITLE: Understanding Infantile Rhabdomyosarcoma Biology and Therapeutic Targets

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: RICHARDSON

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: PROJECT NARRATIVE Relevance As the proportion of older adults in the population continues to expand, magnifying the relative impact of their decisions, it is increasingly imperative to better understand changes in decision making across the life span before and throughout all stages of significant cognitive impairment related to Alzheimers Disease and related dementias. Increasing interdisciplinary research combining psychology, neuroscience/neurology, medicine, and economics has tremendous potential for increasing translation of science for real-world impact to better understand and alleviate the burden of Alzheimers Disease and related dementias. The long-term goal of this network is to conduct integrative and multidisciplinary research that contributes directly to interventions aimed at improving health and well being in the daily lives of aging adults.

PI_NAMEs: LIGHTHALL, NICHOLE ;SEAMAN, KENDRA LEIGH (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Adult;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Award;Awareness;Basic Science;behavior measurement;Behavioral;Biological;Brain imaging;career;career networking;Clinical;Clinical assessments;Clinical Research;Collaborations;Collection;computer science;data access;Data Aggregation;Data Set;data sharing;Decision Making;Development;Discipline;Documentation;Economics;Educational workshop;effective intervention;Ensure;Faculty;Fellowship;Fostering;Funding;Future;Goals;graduate student;Grant;Growth;Health;imaging modality;Impaired cognition;improved;Individual;Institution;Interdisciplinary Study;interest;Intervention;Investments;Leadership;life span;Link;Measures;Medicine;meetings;member;Mentorship;Methodology;Methods;Modeling;multidisciplinary;Neurology;Neurosciences;older adult;Patient Recruitments;Personal Satisfaction;Policies;Population;Positioning Attribute;Postdoctoral Fellow;Process;programs;Psychology;Public Health;Qualitative Research;recruit;Recruitment Activity;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;Role;Science;Scientist;senior faculty;skill acquisition;social;Sociology;Students;success;Supercomputing;support network;symposium;theories;tool;Training;Training Programs;Translational Research;undergraduate student;Underrepresented Minority;Update;Woman;Work

PROJECT_TITLE: Research Network on Decision Neuroscience and Aging


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE In African Americans, prostate cancer is characterized by higher aggressiveness, more extensive metastases, early- onset, and increased mortality rates than those in Caucasian Americans. We hypothesize that the racial disparity in prostate cancer diagnosis can be reduced by using racially associated magnetic resonance imaging (MRI) analysis. The proposed MRI-based analysis model will be evaluated for men of different racial/ethnic characteristics at the University of California Los Angeles (UCLA) and the University of Alabama at Birmingham (UAB).

PI_NAMEs: KIM, HARRISON ;SUNG, KYUNG HYUN  (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: 3D Print;Address;African American;African American population;Age;Alabama;algorithm development;Anatomy;Biopsy;Blood Vessels;California;cancer diagnosis;Cancerous;caucasian American;Characteristics;Clinical;clinical research site;clinically significant;Computer software;contrast enhanced;Data;Data Set;Death Rate;deep learning algorithm;deep learning model;density;Detection;Diagnostic;digital;early onset;Ethnic Origin;Ethnic Population;Extracellular Space;Image;Imaging Techniques;improved;Incidence;Information Systems;Institution;Lesion;Link;Los Angeles;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Measurement;Measures;men;Modeling;Molds;Names;Neoplasm Metastasis;non-invasive imaging;Pathologic;Pathology;Patients;Performance;Perfusion;Peripheral;point of care;portability;predictive modeling;Prospective cohort;Prostate;Prostate-Specific Antigen;Prostatic Neoplasms;Race;racial disparity;Radical Prostatectomy;Radiology Specialty;recruit;Reporting;Reproducibility;Risk;Schedule;Scheme;Screening for Prostate Cancer;self-attention;Specific qualifier value;Specificity;Standardization;Testing;Tissues;tumor;tumor microenvironment;United States;Universities

PROJECT_TITLE: Racially-associated MRI analysis and modeling for predicting aggressive prostate cancer

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Dental, Oral, and Craniofacial Disease;Networking and Information Technology R&D (NITRD)

ORG_CITY: Cleveland

ORG_NAME: OPSICLEAR LLC

PHR: Project Narrative Malignant tissue removed during surgeries is frozen, sectioned into thin slices, stained, imaged with a microscope (2D images), and assessed by pathologists to provide intraoperative consultations. The frozen section procedure is lengthy, slows down surgeries, inflicts extra operating room cost, and is less accurate than permanent sections. Here, we will develop a product that quickly prepares the tissue and enables 3D visualization of the tissue, potentially saving time, money, and lives.

PI_NAMEs: LIU, YEHE  (contact)

PROGRAM_OFFICER_NAME: FRANCA-KOH, JONATHAN C

PROJECT_TERMS: 3-Dimensional;accurate diagnosis;Address;Affect;Algorithms;analytical tool;Artificial Intelligence;Benchmarking;Calibration;cancer surgery;Capital;Classification;Clinical;Clinical Oncology;Clinical Pathology;Clinical Trials;clinically relevant;Color;Consultations;cost;Data;Data Analyses;Data Set;data visualization;Databases;Death Rate;design;design verification;Evaluation;Excision;experimental study;Feedback;Formalin;Freezing;Frozen Sections;graphical user interface;Head and Neck Cancer;Head and Neck Neoplasms;Head and neck structure;Histology;Histopathology;Image;Imaging Device;imaging system;Imaging technology;Immunohistochemistry;improved;improved outcome;innovation;Innovation Corps;Liquid substance;Maintenance;Malignant - descriptor;manufacturing scale-up;Methods;Microscope;microscopic imaging;Microscopy;Morphologic artifacts;Network-based;neural network;novel;Operating Rooms;Operative Surgical Procedures;Optics;Outcome;Paraffin Embedding;Pathologist;Pathology;Phase;Play;Postoperative Period;pre-clinical;Preparation;Procedures;Process;Protocols documentation;prototype;Reagent;Resected;Resolution;Resources;Risk;Sampling;Sampling Errors;screening;Slice;Slide;Specific qualifier value;Specimen;Stains;success;Surgeon;surgery outcome;Surgical Oncology;Techniques;Technology;Temperature;Testing;Thick;Thinness;Three-Dimensional Imaging;three-dimensional visualization;Time;tissue preparation;tissue processing;Tissues;tool;Training;Translating;tumor;user friendly software;user-friendly;Validation;virtual;wasting;Work

PROJECT_TITLE: 3D optical histopathology for head and neck intraoperative consultation.


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Muscular Dystrophy;Orphan Drug;Precision Medicine;Rare Diseases

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE Differences in our individual genomes give rise to most of human diversity, including the severity of disease presentations and responses to therapeutic interventions. Yet, the component of genetic diversity has been largely ignored in preclinical studies, including in muscular dystrophies. This project aims to revolutionize the conventional method by which we develop genetic therapy in muscular dystrophy to reflect diverse patient populations.

PI_NAMEs: KEMALADEWI, DWI UTAMI (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: adverse outcome;Animals;Award;Biological;Biology;career;Clinical Treatment;Clinical Trials;design;Diagnosis;Disease;disease phenotype;experimental study;Failure;Future;gene therapy;Genetic;Genetic Anticipation;Genetic Variation;Genome;genome editing;genomic variation;Goals;Human;Inbred Strains Mice;Inbreeding;Individual;Inherited;innovation;Methods;Modeling;Mus;Muscular Dystrophies;Mutation;neuromuscular;Outcome;patient population;Patients;Population;precision medicine;preclinical study;response;Safety;Severity of illness;Technology;therapeutic development;therapeutic genome editing;Therapeutic Intervention;Treatment Efficacy;United States National Institutes of Health

PROJECT_TITLE: Implications of Genetic Diversity in Muscular Dystrophy


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE Telephone-based cognition testing is cost-effective and lends itself more easily to a broader range of populations than in-person face-to-face testing. However, scores obtained from phone-based testing differ systematically from more traditional face-to-face testing, and comparability across modes of test administration is critical for interpreting scores in research studies. The primary objective of this administrative supplement to the SWAN Aging U19 aims is to conduct a cross-calibration study in a new sample of N=100 women, of similar age as SWAN V17 participants (age range, 66-76 years) to create test-score adjustment/correction formulas that incorporate differences by level of cognitive functioning.

PI_NAMEs: BROOKS, MARIA MORI (contact);DERBY, CAROL A.;HEDDERSON, MONIQUE MARIE;JANSSEN, IMKE ;KARLAMANGLA, ARUN S;THURSTON, REBECCA C;WAETJEN, L ELAINE

PROGRAM_OFFICER_NAME: DUTTA, CHHANDA

PROJECT_TERMS: Administrative Supplement;Affect;Age;Aging;Attention;Back;black women;Calibration;cardiovascular risk factor;caregiving;Clinic;Clinical;Cognition;Cognitive;cognitive function;cognitive performance;cognitive testing;cohort;cost effective;COVID-19 pandemic;Data;Education;Episodic memory;Equation;Ethnic Origin;Exposure to;Financial Hardship;follow-up;Future;Health;Home;Home environment;home test;human old age (65+);Impaired cognition;Individual;Japanese;Language;Language Tests;Light;Longitudinal Studies;Memory;middle age;multi-ethnic;Needs Assessment;Participant;Performance;Perimenopause;Persons;Population;Predisposition;preference;processing speed;Race;Randomized;recruit;Research;research study;Sampling;Sampling Studies;Short-Term Memory;Site;Spanish;Spouses;Study of Women's Health Across the Nation;Telephone;telephone based;Testing;Time;verbal;Visit;White Women;Woman;Women's cohort

PROJECT_TITLE: The Study of Women's Health Across the Nation (SWAN): The Impact of Midlife and the Menopause Transition on Health and Functioning in Early Old Age


NIH_SPENDING_CATS: Genetics;Neurodegenerative

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: In living things, proteins with a reduced diversity of their amino acid building blocks play an integral role in the organization of biochemical activity in time and space. These proteins are of fundamental importance to the understanding of human health as more than 30% of the proteins coded by human genome have this characteristic, many of which are genetically linked to disease. The proposed research will provide an understanding of fundamental microscopic protein chemistry underlying macroscopic biological activity that will be useful for improving treatments for neurodegenerative diseases and cancers.

PI_NAMEs: MURRAY, DYLAN THOMAS (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Amino Acid Sequence;Amino Acids;Antibodies;base;Behavior;Binding;Biochemical;Biological;Biological Assay;Biological Process;biological systems;biophysical analysis;biophysical techniques;Cells;Characteristics;clinical biomarkers;Code;Coupled;Cryoelectron Microscopy;Cytoplasmic Granules;Cytoskeleton;Dementia;Development;Disease;DNA Sequence Alteration;Health;Human;Human Genome;improved;In Vitro;in vivo;Intermediate Filaments;Investigation;Knowledge;Life;Link;Malignant Neoplasms;Membrane;Methodology;Microscopic;Modeling;Molecular;Molecular Conformation;Molecular Structure;Motor Neuron Disease;Muscular Dystrophies;Neurodegenerative Disorders;Nuclear Magnetic Resonance;Organelles;Pathogenicity;Play;Point Mutation;Post-Translational Protein Processing;Process;Property;Protein Chemistry;Protein Dynamics;Protein Engineering;protein expression;protein protein interaction;Proteins;Research;RNA;RNA metabolism;Role;self assembly;small molecule therapeutics;Spectrum Analysis;System;Tertiary Protein Structure;Time;tool;Work

PROJECT_TITLE: Low-complexity domain protein molecular structure, conformational dynamics, and inter-protein interactions in human health and disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Pediatric

ORG_CITY: PORTLAND

ORG_DEPT: DENTISTRY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Severe early childhood dental caries (SECC) constitutes a significant economic burden, can have dramatic impact on a child's well being and may contribute to overall health later in life. Studies of clinical Streptococcus mutans strains are needed to investigate the diversity of novel small molecule metabolites produced by biosynthetic gene clusters and their impact on the pathogenesis of dental caries. Identification of novel metabolites from cariogenic S. mutans may lead to the development of new therapeutics that can effectively treat or even prevent SECC.

PI_NAMEs: MOMENI, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: 5 year old;6 year old;Acids;Affect;Age;Animal Model;anti-microbial peptide;Appointment;Award;Bacteria;Bacterial Model;biological adaptation to stress;butyrolactone;Career Choice;Child;Child Health;Child Welfare;CISH gene;Clinical;clinical phenotype;clinical translation;Collaborations;Communicable Diseases;Data;Dental caries;Dental Research;design;Development;Drosophila genus;early childhood;Economic Burden;environmental stressor;Epidemiology;epidemiology study;fitness;fly;Gene Cluster;Gene Expression;Genes;Genetic Transcription;Genome;genome sequencing;Genotype;Health;health disparity;high risk;Human;Hybrids;In Vitro;in vivo;insight;Ions;Journals;Knock-out;Knowledge;Lead;Life;Liquid Chromatography;liquid chromatography mass spectrometry;Maps;metabolomics;microbial;Microbial Biofilms;Modeling;Molecular Biology;multidisciplinary;Mutagenesis;mutant;Mutation;new therapeutic target;novel;novel therapeutics;Oral health;oral microbiome;Pathogenesis;Phase;Phenotype;Population;prevent;programs;Property;Publications;Publishing;Rattus;RBM5 gene;Recombinants;Research;Research Training;Risk;Role;small molecule;Streptococcus mutans;study population;tandem mass spectrometry;targeted treatment;Testing;Time;trait;transcriptome sequencing;transcriptomics;Virulence;virulence gene;Virulent;whole genome;Work

PROJECT_TITLE: Novel small molecule biosynthetic gene clusters in Streptococcus mutans and virulence of dental caries

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Children with autism spectrum disorder who receive intervention earlier in life show larger gains in language skills and improved overall development; presymptomatic intervention during infancy may soon be feasible because recent research advances have lowered the age of possible detection to 6-months. The proposed study will inform future presymptomatic interventions by identifying infant-based language and communication risk markers, caregiver-based intervention targets, and brain-based monitoring biomarkers. The objectives of this proposal align with the NIDCD Strategic Plan Priority Areas in Voice, Speech, and Language Research by: 1) understanding diseases and disorders; 2) improving diagnosis, treatment, and prevention; and 3) improving outcomes for human communication.

PI_NAMEs: SWANSON, MEGHAN RAE (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Address;Adult;Age;Age Months;Area;autism biomarker;Autism Diagnosis;autism spectrum disorder;autism symptoms;autistic children;Axon;Biological Markers;Brain;brain based;brain behavior;Brain region;care costs;Caregivers;Child;Classification;clinical practice;Collaborations;Communication;Companions;Crying;Data;Detection;Development;Diagnosis;Diagnostic;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Distress;Early Intervention;economic cost;evidence base;Exposure to;forging;Funding;Future;Goals;Growth;Hearing;high risk;high risk infant;Home;Human;Image;improved;improved outcome;individuals with autism spectrum disorder;infancy;Infant;Infant Development;Intervention;intervention effect;Intervention Studies;Knowledge;Language;Laughter;Length;lexical;Life;Linguistics;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Mediating;meetings;Monitor;National Institute on Deafness and Other Communication Disorders;neurodevelopment;Neuronal Plasticity;Outcome;Parents;peer;Play;Predisposition;prefrontal lobe;Prevention;Probability;protective effect;public health relevance;Research;Research Personnel;Risk;Risk Marker;Sampling;Siblings;skills;social communication;Specific qualifier value;Speech;Strategic Planning;Structure;Temporal Lobe;Time;Treatment Efficacy;United States National Institutes of Health;Validation;vocalization;Voice;white matter;Work

PROJECT_TITLE: Caregiver Speech and Brain-Behavior Development in Infants At-Risk for ASD

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]