NIH_SPENDING_CATS: Aging;Cardiovascular;Heart Disease;Machine Learning and Artificial Intelligence;Prevention

ORG_CITY: NOVATO

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

PHR: PROJECT NARRATIVE The proposed research is of significant clinical relevance as it uses some of the largest health databases in the world to generate novel metrics of the biological age of different organs based on clinical measurements that can be used in different populations. Additionally, by identifying blood biomarkers of organ age, the proposed study has the potential to assess from a blood sample from a person which of their organs are aging faster and more susceptible to diseases. Furthermore, by focusing on blood markers of cardiac dysfunction during aging, this study will aim to define new targets and pharmacological interventions to maintain cardiac function during aging.

PI_NAMEs: FURMAN, DAVID  (contact)

PROGRAM_OFFICER_NAME: GAO, HONGWEI

PROJECT_TERMS: Acceleration;Affect;Age;age effect;age related;Aging;aging biomarker;aging process;aging related;aging reversal;Animal Model;Atlases;Automobile Driving;biobank;biological age;Biological Markers;Blood;Blood Circulation;Blood specimen;candidate marker;candidate selection;Cardiac;cardiac aging;Cardiac health;Cardiac Myocytes;Cardiovascular Diseases;cardiovascular health;Cause of Death;Cell Aging;Cell secretion;Cells;chemokine;Chronic Disease;Clinical;Clinical Data;clinically relevant;combat;cytokine;Data;Databases;deep learning;design;Detection;Deterioration;Dietary Factors;Disease;disorder risk;Distant;drug discovery;Drug Kinetics;drug repurposing;Echocardiography;Electrophysiology (science);Endothelial Cells;epigenomics;Equation;Event;experience;experimental study;Female;Functional disorder;Future;Genes;Genetic;Genotype-Tissue Expression Project;Growth;Growth Factor;Health;Heart;Heart Diseases;heart function;heart rate variability;Human;human induced pluripotent stem cells;Image;improved;in vivo;Individual;Inflammatory;Intervention;Intervention Studies;Investigation;Kidney;lifestyle factors;Link;Liver;Longitudinal cohort;Lung;Machine Learning;machine learning method;male;Measurement;Mediating;metabolomics;Methods;Microelectrodes;microscopic imaging;Modeling;Molecular;Monitor;mortality;Multiomic Data;multiple omics;Mus;Muscle;Myocardial Degeneration;Myocardial dysfunction;novel;novel therapeutics;Organ;Organoids;Pattern;Peptide Hydrolases;Persons;Pharmaceutical Preparations;pharmacologic;phenotypic biomarker;phenotypic data;Physiological;Population;Predisposition;prevent;Proteins;Proteomics;quantification of aging;rate of aging;Research;Safety;Sampling;senescence;senescence associated secretory phenotype;senescent cell;sex;Sex Differences;System;Techniques;Testing;Toxic effect;transcriptomics;Transplantation;women versus men

PROJECT_TITLE: Identifying Organ-Specific Blood Biomarkers of Aging and Assessing their Effects on Cardiovascular Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-P (J2)]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Diabetes;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because Alzheimer’s disease and related dementias are significant drivers of disability, health burden, and costs for older adults, their families, healthcare systems, and public programs such as Medicare and Medicaid. The research will discover how high glucose levels from diabetes and pre-diabetes, diabetes treatment, and injury to the brain’s blood vessels impact cognitive function and the risk of Alzheimer’s disease and related dementias. This fundamental knowledge will help develop effective strategies to prevent Alzheimer’s disease and related dementias and preserve cognitive health in adults with diabetes and pre-diabetes.

PI_NAMEs: LEVINE, DEBORAH ALLISON (contact)

PROGRAM_OFFICER_NAME: HOMMER, REBECCA EVE

PROJECT_TERMS: Adherence;Adult;Affect;Age;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Area;Black race;Blood Pressure;Brain;burden of illness;cardiovascular risk factor;Cardiovascular system;Cerebral small vessel disease;Cerebrovascular system;Clinical;clinical care;clinical practice;Clinical Trials;Cognition;Cognitive;cognitive function;cohort;Cohort Studies;cost;Data;Data Pooling;Data Set;Dementia;dementia risk;diabetes control;diabetes management;Diabetes Mellitus;Diabetes prevention;diabetes prevention program;Diagnosis;disability;Ethnic Origin;Event;experimental study;Family;Future;Geography;Glucose;glycemic control;Glycosylated hemoglobin A;Goals;Guidelines;Health;health equity;Health Policy;Health Priorities;Healthcare Systems;high risk;Hyperglycemia;Hypertension;Hypoglycemia;Impaired cognition;Impairment;Individual;Injury;innovation;Interdisciplinary Study;Intervention;Knowledge;late life;Life Cycle Stages;Longitudinal Studies;magnetic resonance imaging biomarker;Measures;Mediation;Medicare/Medicaid;men;Meta-Analysis;Methods;Microvascular Dysfunction;Non-Insulin-Dependent Diabetes Mellitus;older adult;Outcome Study;Participant;Persons;Pharmaceutical Preparations;Population;Population Heterogeneity;Prediabetes syndrome;preservation;prevent;programs;Public Health;Public Policy;Race;racial diversity;Research;Role;Severities;sex;Sex Differences;shared decision making;social health determinants;Stroke;Subgroup;Testing;time interval;Update;vascular cognitive impairment and dementia;vascular risk factor;Woman;young adult

PROJECT_TITLE: Type 2 Diabetes Mellitus and Vascular Contributions to Cognitive Impairment and Dementia (T2DM-VCID)

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: BALTIMORE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Public Health Relevance Blood pressure is lower in females than it is in males. We discovered that a receptor called OLFR558 is responsible for this sex difference. In this proposal, we will work to understand how OLFR558 affects blood pressure, how it acts differently in males versus females, and whether OLFR558 also plays a role in hypertension.

PI_NAMEs: PLUZNICK, JENNIFER L (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Address;Affect;Age;Agreement;Angiotensin II;Animal Model;arteriole;Attenuated;Blood Pressure;blood pressure elevation;blood pressure reduction;Blood Vessels;cell type;Cells;Data;Diastolic blood pressure;Disease;DOCA;experimental study;Female;Four Core Genotypes;G-Protein-Coupled Receptors;Gene Family;Genome;genotypic sex;Health;Human;Hypertension;Incidence;Infusion procedures;Inherited;innovation;insight;Juxtaglomerular Apparatus;Kidney;Knock-out;knockout animal;Knockout Mice;Ligands;LoxP-flanked allele;male;Mediating;Modeling;Mus;Nose;novel;olfactory receptor;Orthologous Gene;Peripheral;Phenotype;Physiologic pulse;Physiological;Play;Premenopause;public health relevance;rare variant;receptor;Renin;Reporting;response;Role;sex;Sex Differences;Signal Transduction;Smooth Muscle Myocytes;Sodium Chloride;Telemetry;Testing;Tissues;tool;Vascular Smooth Muscle;Wild Type Mouse;Woman;women versus men;Work

PROJECT_TITLE: Sex Differences in Blood Pressure and Olfactory Receptor 558 (OLFR558)

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE A radiosynthesis system for the production of fluorine-18 PET radiotracers will significantly advance the scientific investigations of users of the UC Davis Center for Molecular and Genomic Imaging who utilize NIH funding. Diverse areas such as gene therapy, neurology, oncology, toxicology, metabolic disorders, nanotechnology and biomedical engineering stand to directly benefit from the unique capabilities of the system and the plethora of invaluable data it will produce regarding disease initiation, pathogenesis and response to therapy.

PI_NAMEs: SUTCLIFFE, JULIE L (contact)

PROGRAM_OFFICER_NAME: AGGARWAL, MONIKA

PROJECT_TERMS: Animal Model;Area;Biomedical Engineering;companion animal;Core Facility;Cyclotrons;Dedications;Ensure;Fluorine;Functional Imaging;Funding;Future;gene therapy;Genomics;Goals;Image;imaging study;in vivo imaging;Infrastructure;Institution;Location;Maintenance;Metabolic Diseases;Minor;Molecular;molecular imaging;Nanotechnology;Neurology;nonhuman primate;novel;Oncology;operation;Positron;Positron-Emission Tomography;preclinical imaging;Production;Radiochemistry;Radiolabeled;radiotracer;Research;Rodent;System;Systems Integration;Toxicology;translation to humans;Translational Research;United States National Institutes of Health

PROJECT_TITLE: Integrated system for PET radiotracer synthesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-M (30)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: TORRANCE

ORG_NAME: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER

PHR: PROJECT NARRATIVE DNA damage repair pathways are critical for the integrity of the genome, and a better understanding of these pathways will reduce cancer rates and increase the effectiveness of cancer treatment. Triple negative breast cancer is the most aggressive breast cancer subtype and has limited treatment options, but our work will provide a novel strategy to enhance treatment effectiveness for TNBC patients. Knowledge from this study can be applied to other cancer types with frequent DNA damage repair defects, like ovarian and prostate cancer.

PI_NAMEs: WANG, HUA  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: aggressive breast cancer;Binding;BRCA1 gene;Breast Cancer cell line;Breast Cancer Patient;Breast Epithelial Cells;breast tumorigenesis;cancer cell;cancer subtypes;cancer therapy;cancer type;chemotherapy;Chemotherapy and/or radiation;Chromatin;Clinical;Complex;Critical Pathways;Data;Defect;Development;Dissociation;DNA;DNA Damage;DNA lesion;DNA Repair;DNA Repair Gene;DNA replication fork;Double Strand Break Repair;early onset;Effectiveness;G0 Phase;Genetic Transcription;genome integrity;Genome Stability;Genomic Instability;Germ-Line Mutation;helicase;homologous recombination;Human;Hybrids;In Vitro;inhibitor;insight;Ionizing radiation;Knock-in Mouse;Knowledge;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;mammary epithelium;Messenger RNA;Metabolism;metaplastic cell transformation;Methyltransferase;Modification;mouse model;Mus;mutant;Mutate;Mutation;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Pathogenicity;Pathway interactions;patient derived xenograft model;Pattern;Phosphorylation;Phosphotransferases;Physiological;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;Polymerase;prevent;progenitor;Proteins;Proteomics;Radiation;Reader;recombinational repair;recruit;Resolution;response;RNA;RNA Helicase;Role;S phase;Serine;Signal Transduction;Single-Stranded DNA;Site;small molecule;Somatic Mutation;standard care;Testing;Therapeutic Effect;therapeutic target;Treatment Effectiveness;triple-negative invasive breast carcinoma;tumorigenesis;Untranslated RNA;Woman;Work;Xenograft procedure

PROJECT_TITLE: Deciphering functions of the ATR-METTL3-BRCA1 Axis in genome instability and Tumorigenesis

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;HIV/AIDS;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Project Narrative A vaccine for HIV/AIDS should induce antibodies that protect people against all HIV variants. We will test speciﬁc HIV spike vaccines in mice engineered to make human-like antibodies. In multiple redesign-testing steps, we will improve our HIV vaccine in `easier' to `more challenging' mouse models.

PI_NAMEs: VERKOCZY, LAURENT KARL;ZWICK, MICHAEL B (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJALI

PROJECT_TERMS: Adjuvant;Affinity;anergy;Animal Model;Antibodies;Antibody Response;Antibody Specificity;Antibody-mediated protection;Antigens;B-Lymphocytes;Benchmarking;Binding;Binding Sites;Biological Assay;Chimera organism;Clinical;design;Development;Engineering;Equilibrium;Evaluation;follow-up;Frequencies;Genetic;Germ Lines;global health;glycosylation;Goals;Health Priorities;HIV;HIV Envelope Protein gp120;HIV Infections;HIV vaccine;Human;humanized antibody;Immunization;Immunoglobulin G;Immunoglobulin Somatic Hypermutation;improved;Individual;insertion/deletion mutation;Knock-in;Knock-in Mouse;Lead;Length;Link;Liposomes;Membrane;Memory;Memory B-Lymphocyte;Messenger RNA;Minor;Modality;Modeling;Modification;mouse model;Mus;mutant;Mutation;nanoparticle;neutralizing antibody;next generation;novel;novel vaccines;Peptides;Peripheral;Persons;Physiological;pre-clinical;preclinical development;prevent;Protocols documentation;Rattus;reconstitution;Regimen;Reporting;Reproducibility;Resolution;response;Rodent;Rodent Model;Running;Scheme;Serum;Signal Transduction;Site;Standardization;Step Tests;Structure of germinal center of lymph node;Tertiary Protein Structure;Testing;vaccination protocol;Vaccine Design;vaccine evaluation;vaccine platform;Vaccines;Variant;Viral;Virus

PROJECT_TITLE: Combining membrane Env vaccine regimens to elicit multiple bnAb lineages and consistent cross-neutralization of HIV

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: NARRATIVE Tuberculosis, caused by Mycobacterium tuberculosis, remains a major global health problem with >1.6 million deaths annually. Our overall aim is to develop new anti-tubercular drugs that combat resistance and shorten therapy. In this proposal we will develop novel inhibitors of protein secretion, determine their mode of action, and determine their resistance mechanism(s).

PI_NAMEs: PARISH, TANYA  (contact)

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: Affect;Amides;analog;Animal Model;Antibiotics;Antitubercular Agents;Bacteria;Biogenesis;Biological;Biology;Cause of Death;Cell Death;Cell Fractionation;Cell membrane;Cell Physiology;Cell Wall;Cessation of life;Clinical;combat;Communicable Diseases;Data;Development;drug development;Drug resistance;drug-sensitive;Dyes;efficacy testing;Future;Gene Expression Regulation;Generations;global health;Goals;immunoregulation;In Vitro;in vivo;Infection;inhibitor;insight;interest;Lead;lead optimization;Mediating;Metabolic;Metabolic Pathway;mouse model;mutant;Mycobacterium tuberculosis;novel;novel therapeutics;Outcome;Peptide Signal Sequences;Pharmaceutical Preparations;Phenotype;Play;Prevention;programs;Property;Protein Biosynthesis;Protein Secretion;Proteins;Reporter;Resistance;resistance frequency;resistance mechanism;resistant strain;response;Resuscitation;Role;Series;signal peptidase;Stimulus;Structure;Structure-Activity Relationship;Testing;thienopyridine;Tuberculosis;tuberculosis drugs;Virulence;Work

PROJECT_TITLE: Targeting protein secretion in Mycobacterium tuberculosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-U (90)]


ADMINISTERING_IC: MD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: The project proposes to implement HPV vaccination promotion by a healthcare provider during routine healthcare maintenance to increase awareness of its potential benefits and increase HPV vaccination uptake in Hawaii’s PLWH while measuring clinical outcomes associated with uptake.

PI_NAMEs: HEDGES, JERRIS ROBERT (contact);MOKUAU, NOREEN

PROGRAM_OFFICER_NAME: LAI, GABRIEL Y

PROJECT_TERMS: Address;Affect;Antibodies;Anus;Anxiety;Awareness;Basic Science;Behavioral Research;Biomedical Research;Biometry;Blood;cancer education;cancer health disparity;Clinic;Clinical;Clinical Data;clinical decision-making;clinical outcome measures;Clinical Research;community engagement;Cultural Diversity;Cytology;Data;Development;Disease;disparity gap;Dysplasia;Effectiveness;Elements;Eligibility Determination;Enrollment;experience;falls;Feasibility Studies;Fright;General Population;Hawaii;Hawaiian;Health;Health Disparities Research;health disparity;Health Personnel;Health Services Accessibility;Healthcare;high risk population;HIV;HPV vaccine acceptance;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papillomavirus;Immunization Programs;immunogenicity;improved;Incidence;Individual;institutional capacity;Island;Knowledge;Maintenance;Malignant neoplasm of anus;Measurement;Measures;men who have sex with men;Mentors;Minority Groups;minority health;minority health disparity;Outcome;Participant;patient population;Perception;Persons;Population;Population Heterogeneity;Prevention;Productivity;programs;Race;Research;research facility;Research Personnel;Risk;Safety;screening;screening program;Services;social stigma;Specimen;transgender;underserved community;unvaccinated;uptake;Vaccinated;Vaccination;vaccine acceptance;vaccine effectiveness;vaccine efficacy;vaccine immunogenicity;Vaccines;Woman

PROJECT_TITLE: Evaluating HPV Vaccination Uptake Barriers and its Efficacy in PLWH


ADMINISTERING_IC: OH

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: OAKLAND

ORG_NAME: PUBLIC HEALTH INSTITUTE

PHR: PROJECT NARRATIVE Work-related injuries and illnesses in California cost over $30 billion each year with over 400 job-related injury deaths and 480,000 nonfatal injuries and illnesses. The proposed program is to maintain and enhance the capacity of the California occupational health surveillance program to identify state priorities and guide efforts to improve and protect worker safety and health; monitor statistical and other trends and progress over time; and develop and distribute prevention and intervention recommendations.

PI_NAMEs: HARRISON, ROBERT J (contact)

PROGRAM_OFFICER_NAME: O'NEILL, EDUARDO

PROJECT_TITLE: California Occupational Safety and Health Surveillance


ADMINISTERING_IC: DP

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE (in layperson language) The research projects contained in LIFESPAN-D will determine the health and cost-related effects of two large federal nutrition assistance programs (SNAP and WIC) on diabetes outcomes across the life span. Food insecurity is a common, potent factor that leads to type 2 diabetes among low-income populations and contributes to socioeconomic and racial/ethnic difference in health for people with diabetes. We will take advantage of new policies in SNAP and WIC rolling out in California so as to measure the effects of these programs on (a) diabetes care and diabetes complications (such as heart attacks, kidney failure, amputations) among older adults who already have type 2 diabetes, as well as (b) the development of pregnancy-related diabetes or type 2 diabetes or among pregnant mothers and adults with prediabetes, respectively.

PI_NAMEs: SCHILLINGER, DEAN  (contact)

PROJECT_TITLE: DP20-002 - Evaluation of Natural Experiments of Nutrition Assistance to Prevent and Control Diabetes among Low-Income Communities


ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

ORG_STATE: IL

PI_NAMEs: ROSENMAN, MARC B (contact)

PROJECT_TITLE: DP20-001 Assessing the Burden of Diabetes By Type in Children, Adolescents and Young Adults (DiCAYA) - 2020


ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Providing health coverage for 37 million American adults who are poor, aged, or disabled, policy decisions made by state Medicaid programs can have a profound impact on the health and healthcare of people living with diabetes. Our proposed center will combine multidisciplinary strengths in diabetes care, health policy, data science, and causal inference and will leverage existing, unique access to national UnitedHealth Group Medicaid managed care claims and harmonized EHR data, state Medicaid, and Medicare claims from 3 states. With these assets, we will utilize rigorous natural experimental designs for the timely and policy-relevant evaluation of 1) the health and economic effects of different state-level managed care approaches for medication prior authorization and medication refill durations for diabetes medications; and 2) the medium- to longer-term effects of ACA coverage expansion on diabetes care and outcomes.

PI_NAMEs: ACKERMANN, RONALD T. (contact)

PROJECT_TITLE: DP20-002 - Effects of Medicaid Coverage and State-Level Delivery Approaches on Healthcare Quality, Outcomes, and Costs for Adults with Diabetes


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: MURRAY

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: MURRAY STATE UNIVERSITY

ORG_STATE: KY

PHR: The Department of Occupational Safety and Health at Murray State University supplies diversified education and training for occupational safety and health professionals to meet the local, regional, and national demand. Curricula, programs, and training within the department are designed to meet the professional preparation of students as well as the manpower, continuing education, training, and advisory needs of the region and state.

PI_NAMEs: BYRD, TRACI  (contact)

PROJECT_TITLE: Occupational Safety and Health Program Improvement


ORG_CITY: WASHINGTON

ORG_NAME: INTERNATIONAL ASSOCIATION FIRE FIGHTERS

ORG_STATE: DC

PHR: The International Association of Fire Fighters (IAFF) is proud to be a partner with the National Institute of Occupational Safety and Health (NIOSH) for nearly 24 years. The IAFF has continued its nonacademic occupational safety and health training program to meet the specific training needs of fire fighters. The major objective of this program is to address the burden of occupational safety and health among fire fighters by providing state of the art training by translating scientific discoveries into practice through effective education, training, and outreach. The IAFF recognizes that every emergency call is a potential hazardous materials (HazMat) call. Each year thousands of fire fighters are exposed to chemical and biological hazards in the performances of their duties. The IAFF understands that training students in hazards, defensive actions, and to OSHA and NFPA standards can help minimize and eliminate exposures. Our mission is to train all levels of fire fighters in their own departments and customize the training to meet jurisdictional hazards. IAFF programs are developed and taught by highly trained fire fighters who bring valuable experience to the classroom. IAFF training efforts have proven to reduce risk and protect fire fighters safety and health through effective training.

PI_NAMEs: SMITH, JOSHUA  (contact)

PROJECT_TITLE: International Association of Fire Fighters' Emergency Responder Training Program


ORG_CITY: NASHVILLE

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: MEHARRY MEDICAL COLLEGE

ORG_STATE: TN

PHR: Project Narrative Public Health Relevance Statement The Meharry occupational medicine residency program provides high quality training opportunities that will produce exceptional occupational medicine physicians who will positively impact the health of workers and their communities. The importance of this training rests on the continually increasing demand for highly skilled occupational medicine physicians who can effectively address the health needs of a growing and diverse US workforce and ensure the highest standards of occupational health and safety are met. In keeping with the mission of Meharry, the training competencies are geared towards attaining knowledge and skills necessary for serving the healthcare needs of underserved populations.

PI_NAMEs: OGUNDE, BOLANLE  (contact)

PROJECT_TITLE: Meharry Occupational Medicine Residency Training Program


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

ORG_CITY: AMES

ORG_DEPT: MISCELLANEOUS

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: PROJECT NARRATIVE The healthcare response to Ebola, SARS, and COVID-19 has shown that improvements in PPE can improve healthcare worker safety and patient care delivery. The design limitations in current PPE provide challenges for healthcare workers (HCWs), especially while doffing certain components of PPE. The improvement in gowns and respirators could have a substantial impact on public health, both domestically and internationally.

PI_NAMEs: SONG, GUOWEN  (contact)

PROJECT_TITLE: Occupational Safety and Health Research (R01)

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]


ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative This research is necessary to advance methods for using comprehensive healthcare data to estimate chronic disease burden, assessing the reliability and validity of those methods, and comparing to traditional systems. Furthermore, this project will generate and evaluate diabetes incidence and prevalence and will share those estimates via a unique dashboard with public health authorities for the purposes of disease surveillance and prevention.

PI_NAMEs: DIXON, BRIAN E. (contact);MENDONCA, ENEIDA A

PROJECT_TITLE: DP20-001 Leveraging Electronic Health Data to Assess the Burden of Diabetes among Young Adults


ORG_CITY: FLORENCE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF NORTH ALABAMA

ORG_STATE: AL

PHR: PROJECT NARRATIVE  This project helps prepare professionals who are responsible for carrying out the mandate of the United States Occupational Safety and Health Act (OSH Act). The project aims at providing education in occupational health and safety that is broad in scope so the practitioner is prepared to contribute to the advancement of the profession above and beyond the requirements of the law. It is expected that after a few years of practice, trainees will provide guidance and significant support to the advancement of health and safety in the workplace and will be resourceful in applying scientific principles for the diagnosis and control of occupational health problems.

PI_NAMEs: KIMBROUGH, LESHAN J (contact)

PROJECT_TITLE: Occupational Safety and Health Training Project Grant in Industrial Hygiene


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE STATEMENT The UCLA-led Central Coordinating Center (CCC) for the Natural Experiment Research Centers will work across individual study sites to support and sustain them as a research Network evaluating real-world programs designed to enhance diabetes prevention and treatment. The CCC will provide common administrative and technical support for in-person and telephone/video Network meetings, facilitate communications between study sites and the Centers for Disease Control and Prevention (CDC), and promote the accomplishments of the Network to audiences beyond those reached by an individual site.

PI_NAMEs: DURU, OBIDIUGWU KENRIK (contact)

PROJECT_TITLE: DP20-002 UCLA-led Central Coordinating Center (CCC) for the Natural Experiment Research Network


PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE STATEMENT United Healthcare has implemented an innovative program for its members with the most complicated and expensive health care needs, called the National Care Coordination (NCC) program. The impact of the NCC program on the care of adult enrollees with commercial insurance, specifically those who have diabetes, is a critical and timely question that remains unanswered. Our team will work in collaboration with UHC and the CDC to evaluate the impact of this program to inform future UHC strategies and national policies of care coordination for patients with complicated health care conditions.

PI_NAMEs: DURU, OBIDIUGWU KENRIK;MANGIONE, CAROL M (contact)

PROJECT_TITLE: DP20-002 A Pragmatic Nationwide RCT of Coordinated Medical, Behavioral, and Social Services to Improve Care and Utilization among High-Cost, High-Need Insured Patients with Diabetes


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: COLUMBIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: NARRATIVE Diabetes mellitus is one of the most common chronic diseases in the United States and the prevalence seems to be increasing. South Carolina DiCAYA Youth is a state-wide, population-based surveillance effort tailored to estimate diabetes incidence and prevalence in children and adolescents under the age of 18 by type of diabetes, age, sex, race/ethnicity, and geography, and builds on the SEARCH for Diabetes in Youth registry effort in South Carolina and nationally. Understanding the burden of diabetes in youth will assist with future health care planning and public health prevention efforts.

PI_NAMEs: LIESE, ANGELA D (contact)

PROJECT_TITLE: DP20-001 DiCAYA: South Carolina Youth (Component A)


ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: Project Narrative Diabetes is one of the most common chronic diseases among adults, effecting over 30 million people in the United States in 2017, with young adults ages 18-44 years accounting for ~ 3 million cases with limited information on diabetes type. Ongoing, efficient surveillance is essential to inform health care delivery systems and generate testable hypotheses related to the natural history of diabetes in this age group. The current study seeks to assess the long-term trends of the prevalence, incidence and early clinical characteristics of young adults with diabetes in our racially and ethnically diverse population to assist in the identification of sub- populations for focused efforts on diabetes prevention and reduction in co-morbidities.

PI_NAMEs: REYNOLDS, KRISTI  (contact)

PROJECT_TITLE: DP20-001 Assessing the Burden of Diabetes by Type in Children, Adolescents and Young Adults (DiCAYA) - Component B (18 to < 45 yrs)


ORG_CITY: MINEOLA

ORG_NAME: NEW YORK UNIVERSITY D/B/A NYU LONG ISLAND SCHOOL OF MEDICINE

ORG_STATE: NY

PI_NAMEs: DIVERS, JASMIN  (contact)


ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Over 30 million people in the United States live with diabetes mellitus, and many suffer from diabetes-related complications. The Patient Protection and Affordable Care Act had a positive impact on patients' health insurance rates, healthcare access, and health outcomes yet we do not know the long-term impact of the affordable care act, nor the effect of health insurance instability, on diabetes-related complications. Answering these questions is critical to informing current decisions being made regarding the future of the Affordable Care Act and additional healthcare reforms being brought forth that could impact millions of patients living with diabetes.

PI_NAMEs: HUGUET, NATHALIE  (contact)

PROJECT_TITLE: DP20-002 ACE-D: Assess insurance Coverage Expansion on Diabetes complications


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Over the last decade, increases in diabetes complications such as hyperglycemic coma and heart attack have paralleled increases in out-of-pocket health costs among people aged 18-64. This project will determine whether 3 natural experiments that reduce out-of-pocket costs improve acute and chronic diabetes complications over the longer term. Results could provide evidence about actionable interventions at the Federal, state, and employer level that improve the health of diabetes patients.

PI_NAMEs: WHARAM, JAMES FRANKLIN (contact)

PROJECT_TITLE: Natural Experiments of the Impact of Population-targeted Policies to Prevent Type 2 Diabetes and Diabetes Complications - 2020


ED_INST_TYPE: OVERALL MEDICAL

ORG_CITY: TYLER

ORG_NAME: UNIVERSITY OF TEXAS HLTH CTR AT TYLER

ORG_STATE: TX

PHR: Project Narrative (Public Health Relevance) This Training Project Grant proposal is in keeping with the Centers for Disease Control and Prevention Healthy People 2020 (also with the new 2030 framework) and the NIOSH mandate to provide an adequate supply of qualified personnel to carry out the purposes of the Occupational Safety & Health Act. The main objectives are to: 1) seek support for sustaining and increasing the number of occupational medicine trained physicians who have broad experience and sufficient competence to enter practice without direct supervision, and 2) bring a dimension of training that emphasizes the occupational health needs of the rural workforce with special attention to agriculture. This will be accomplished through a multi-faceted approach including a didactic course of study, including the Agromedicine Workshop, exposure to outreach and research activities at the NIOSH Southwest Center for Agricultural Health, Injury Prevention and Education (SW Ag Center); a supervised practicum experience in collaboration with the Rural Family Medicine Residency Program in Pittsburg, TX and with the National Center for Farmworker Health (NCFH) and affiliated Migrant and Community Health Centers; and field experiences such as worksite “walkthroughs” at industrial, agricultural and rural job locations. .

PI_NAMEs: NESSIM, DALIA E (contact)

PROJECT_TITLE: Innovative Training Experiences for Occ Med Residents in Non-urban & Ag Settings


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Electronic Nicotine Delivery Systems;Lung;Lung Cancer;Patient Safety;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: HOUSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE  The proposed research is relevant to public health because it will increase understanding of the acceptability and health consequences of switching from cigarettes to electronic cigarettes among older adult smokers at high risk for lung cancer who are currently uninterested in quitting smoking. By switching to electronic cigarettes, older adult smokers will potentially reduce health risks that are associated with cigarette smoking, such as nicotine dependence and inflammation.

PI_NAMEs: CINCIRIPINI, PAUL MICHAEL;ROBINSON, JASON D (contact)

PROGRAM_OFFICER_NAME: MAYNE, RACHEL G

PROJECT_TERMS: addiction;Address;Adult;Affect;Alkaloids;Behavior;Benefits and Risks;Biological Markers;C-reactive protein;Cancer Etiology;Carbon Monoxide;CCL2 gene;Cessation of life;Chronic;Chronic Disease;Cigarette;cigarette smoke;Cigarette Smoker;cigarette smoking;Clinic;Clinical Trials;Consumption;Counseling;craving;Data;Dependence;Dinoprost;Ecological momentary assessment;Electronic cigarette;electronic cigarette use;Electronic Nicotine Delivery Systems;Genus Mentha;Glutamates;Guidelines;Health;Health Policy;high risk;high risk population;IL17 gene;Inflammation;Inhalation;innovation;interest;Interferon Type II;Interleukin-1 beta;Interleukin-12;Interleukin-6;Interleukin-8;JUUL;Lecithin;Leukocytes;lung cancer screening;Lysophosphatidylcholines;Malignant neoplasm of lung;Malignant Neoplasms;Mango - dietary;Measures;Mediating;men;Metabolic;Metabolism;metabolomics;Minor;National Comprehensive Cancer Network;Nicotine;Nicotine Dependence;Nicotine Withdrawal;non-smoker;older adult;Outcome;Outcome Measure;Oxidative Stress;oxidized low density lipoprotein;Participant;Population;primary outcome;Process;prospective;Psychological reinforcement;Public Health;Randomized;receptor for advanced glycation endproducts;Research;Risk;Safety;Sampling;Science;Serum;Shapes;Smoke;Smoker;smoking cessation;smoking prevalence;smoking-related disease;standard care;Symptoms;TNF gene;Tobacco;Tryptophan;Virginia;Weight;White Blood Cell Count procedure;Woman

PROJECT_TITLE: The potential risks and benefits of electronic cigarettes to older smokers at high risk for lung cancer


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Gene Therapy;Genetics;Immunotherapy;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative Engineered T cell therapy can effectively kill ovarian cancer cells, but there are still tumor-driven hurdles that T cells must overcome to truly beat ovarian cancer. The goals of the proposed research are to understand precisely how these tumors can block killing by T cells and to develop rational strategies to enhance cancer- killing without causing adverse side effects. Many solid tumors escape T cell therapy using the same obstacles that ovarian cancer employs, so our findings will likely help improve immunotherapies against multiple cancer types.

PI_NAMEs: ANDERSON, KRISTIN GAIL (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: Address;Adoptive Cell Transfers;Adoptive Transfer;Affinity;anti-cancer;anti-PD-1;Antibodies;Antigen Targeting;Antigens;Autoantigens;Autologous;Blocking Antibodies;cancer cell;Cancer cell line;cancer infiltrating T cells;cancer type;CD8-Positive T-Lymphocytes;Cell Culture Techniques;Cell Line;Cell Physiology;Cells;chemotherapy;chimeric antigen receptor;Clinical;clinical development;clinically relevant;cytokine;cytotoxic;Cytotoxic T-Lymphocytes;Data;Diagnosis;effective therapy;engineered T cells;Engineering;Flow Cytometry;Functional disorder;Gene Modified;Genes;Goals;Human;Immune;immune checkpoint;immune checkpoint blockade;Immune response;Immunocompetent;Immunohistochemistry;Immunosuppression;Immunotherapy;improved;In Situ;in vivo;Infiltration;insight;knock-down;Knowledge;Ligands;Ligation;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;mesothelin;Methods;Modeling;Molecular Profiling;mouse model;Mus;Myeloid Cells;novel;novel strategies;Outcome;ovarian neoplasm;overexpression;Pathway interactions;Patient-Focused Outcomes;Phenotype;pre-clinical;Pre-Clinical Model;Production;programmed cell death protein 1;Proteins;Publishing;receptor;receptor expression;Receptor Signaling;Research;Resistance;response;Sampling;side effect;Signal Pathway;Signal Transduction;Slice;Solid Neoplasm;System;systemic toxicity;T cell response;T cell therapy;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;Tissues;Toxic effect;transcriptomics;tumor;Tumor Debulking;Tumor Escape;tumor growth;tumor microenvironment;Tumor-infiltrating immune cells;United States;women's diagnosis;Work

PROJECT_TITLE: Engineering T cells to overcome inhibitory receptor signals that limit the efficacy of adoptive cell therapy against ovarian cancer


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative Type 2 diabetes is increasingly prevalent among women during their childbearing years and disproportionately impacts Black and Latina women. Type 2 diabetes increases the risk of maternal and neonatal morbidity and mortality, but there are currently no evidence-based strategies to implement clinical guidelines for improving reproductive outcomes among adult women with type 2 diabetes. The proposed research will advance our understanding of clinical and health system approaches to improving reproductive health outcomes and delivering reproductive health care to reproductive-aged Black and Latina women with type 2 diabetes, by: 1) elucidating their reproductive decision-making processes and reproductive health care preferences using person-centered and structural competency frameworks, 2) adapting an existing patient decision support intervention to support reproductive decision-making and reproductive health counseling delivery in primary care to meet the needs of this population, and 3) assessing acceptability and feasibility of the adapted intervention and examining the implementation context for the intervention.

PI_NAMEs: MARSHALL, CASSONDRA  (contact)

PROGRAM_OFFICER_NAME: PATEL, ANURADHA DIPAK

PROJECT_TERMS: acceptability and feasibility;Address;Adult women;adverse outcome;adverse pregnancy outcome;Affect;Age;aged;apprenticeship;Area;Black race;California;care preference;care systems;career development;Caring;child bearing;Chronic;Climate;Clinical;Clinical Services;Competence;Conceptions;Congenital Abnormality;Consolidated Framework for Implementation Research;Contraceptive Agents;Counseling;Decision Making;design;Development;Diabetes Mellitus;early pregnancy;Educational workshop;effectiveness/implementation trial;Environment;Equilibrium;ethnic disparity;ethnic minority;Ethnic Minority Women;evidence base;experience;Family Planning Center;field survey;Funding;glycemic control;Goals;Guidelines;Health;Health Personnel;Health Services;Health Services Research;Health system;Healthcare;healthy pregnancy;high risk;implementation context;implementation science;implementation strategy;improved;Infant Health;Infant Mortality;informant;interest;Intervention;Interview;K-Series Research Career Programs;Latina;Maternal Health;Maternal health equity;maternal morbidity;Maternal Mortality;maternal risk;Medical;Mentored Research Scientist Development Award;Mentors;Methods;Minority Women;mortality;Multiple Pregnancy;National Institute on Minority Health and Health Disparities;Neighborhood Health Center;neonatal morbidity;Non-Insulin-Dependent Diabetes Mellitus;organizational readiness;Outcome;patient oriented;Patients;person centered;Population;Positioning Attribute;post-doctoral training;Pre-Eclampsia;preference;Pregnancy;Pregnancy Complications;Pregnant Women;Premature Birth;prepregnancy;Prevalence;prevent;Primary Care;primary care provider;primary care setting;Process;Provider;Public Health;racial disparity;racial minority;racial minority women;racism;Recommendation;Reporting;reproductive;Reproductive Health;reproductive health intervention;reproductive outcome;Research;Research Activity;Research Infrastructure;Research Personnel;Research Training;Risk;Risk Reduction;Science;Site;stillbirth;support tools;Surveys;Testing;Training;Training Activity;Training Support;Translations;United States;usability;White Women;Woman;Women's prevalence;young woman

PROJECT_TITLE: Developing a Primary Care Intervention to Support Reproductive Decision-Making among Black and Latina Women of Reproductive Age with Type 2 Diabetes


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Epilepsy;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Pediatric;Rehabilitation

ORG_CITY: PITTSBURGH

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: The overarching goal of this proposal is to examine the organization and recovery of visual functions following large posterior cortical resections in childhood. Cutting-edge psychophysical and neuroimaging procedures, as well as novel analytic approaches, will be employed to elucidate the nature and changes in topography and selectivity of the cortical and subcortical visual system pre- and post-surgery (and longitudinally thereafter), and the mechanisms that give rise to the restitution of function. Examining the consequences of such resections provides a rare but highly informative window into neural plasticity that can contribute significantly both to a fundamental understanding of the visual system and to clinical and translational application (possible rehabilitation methods and guidance for surgical protocols).

PI_NAMEs: BEHRMANN, MARLENE  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Adopted;Age;Attention;Automobile Driving;Basic Science;Behavior;Behavioral;Biography;Brain;Brain region;Categories;Cerebral Dominance;Cerebral hemisphere;Child;Childhood;Clinical;clinical application;cognitive function;common treatment;Competence;Data;data acquisition;design;Development;Dorsal;early childhood;Epilepsy;Excision;Exhibits;extrastriate visual cortex;Face;Frequencies;Functional Magnetic Resonance Imaging;Funding;Goals;Grain;Hemispherectomy;Heterogeneity;Individual;Individual Differences;innovation;insight;Intervention;Investigation;Left;Lobectomy;Methods;movie;Nature;neural;neural correlate;neuroimaging;Neuronal Plasticity;Normalcy;novel;Operative Surgical Procedures;Parietal;patient population;patient subsets;Patients;Pattern;pediatric patients;Population;postoperative recovery;Predictive Factor;preservation;Procedures;Property;Protocols documentation;Psychophysics;Recovery;Recovery of Function;Recovery Support;Rehabilitation therapy;Research;Residual state;response;Role;Seizures;Side;Structure;therapy design;Time;translational applications;Translational Research;Vision;Visual;Visual Cortex;Visual Pathways;Visual System;Work

PROJECT_TITLE: Reorganization of visual function in patients with posterior cortical research: Selectivity and plasticity

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BALTIMORE

ORG_NAME: BALTIMORE VA MEDICAL CENTER

ORG_STATE: MD

PHR: In the aging Veteran population, the prevalence of acute disabling events and chronic diseases will continue to escalate. Dr. Ryan’s ongoing research tests interventions to improve the health in aging Veterans after stroke and in those with diseases and comorbidities including obesity, HIV, and cancer. Her work develops exercise rehabilitation strategies to improve cardiorespiratory fitness and strength and reduce sarcopenia by providing new information to guide risk reduction and potential rehabilitative strategies in older Veterans. She also designs creative rehabilitative mechanistic research translating findings from the bedside to understanding basic mechanisms underlying disability at the cellular and molecular level. Dr. Ryan’s research, leadership, service, and mentoring combine to enhance the independence of aging Veterans.

PI_NAMEs: RYAN, ALICE S. (contact)

PROJECT_TERMS: Acute;Adipose tissue;Advocate;Aerobic Exercise;Affect;age acceleration;Aging;aging process;American;Appointment;Atrophic;Attitude;Award;Baltimore;bench-to-bedside translation;Blood Vessels;Body System;Body Weight decreased;Breast;Capsicum;cardiorespiratory fitness;cardiovascular fitness;Cardiovascular system;career;Caring;Catastrophic Illness;China;Chronic;Chronic disability;Chronic Disease;Clinical;clinical center;Clinical Investigator;Clinical Sciences;Collaborations;Communicable Diseases;comorbidity;COVID-19;Creativeness;deconditioning;design;Development;Diabetes Mellitus;disability;Disabling;Discipline;Disease;Doctor of Medicine;Doctor of Philosophy;Education;Endothelium;Energy Metabolism;Environment;epigenetic aging;Event;evidence base;Exercise;Exercise Physiology;exercise rehabilitation;Exercise Therapy;exercise training;Fatty acid glycerol esters;flexibility;frontier;functional independence;functional restoration;GDF8 gene;Geriatrics;Gerontology;Goals;Grant;Guidelines;Health;Health Personnel;Health Promotion;Healthcare Systems;hemiparetic stroke;HIV;HIV Infections;Hyperinsulinism;Impairment;improved;Infiltration;Inflammation;innovation;Insulin Resistance;insulin sensitivity;interest;Intermittent fasting;International;Intervention;Intervention Trial;Intramuscular;Investigation;K-Series Research Career Programs;Knowledge;Leadership;Life Style;Limb structure;Link;Lung;Malignant Neoplasms;Maryland;Medical;medical schools;Medical Students;Medicine;member;Mentors;Metabolic;military veteran;Mission;Mitochondria;mode of exercise;Molecular;Multi-Institutional Clinical Trial;Muscle;Muscle Development;Muscle Fibers;muscle hypertrophy;muscle metabolism;Muscular Atrophy;Musculoskeletal System;Nature;Nervous System Disorder;Neurology;next generation;Non-Insulin-Dependent Diabetes Mellitus;novel;nutrition;Nutritional Support;Obesity;older adult;Older Population;Oncology;Operative Surgical Procedures;Oxidative Stress;Palliative Medicine;Paresis;patient oriented;patient oriented research;patient population;Peripheral arterial disease;Persons;Physical activity;Physical Medicine;Physical therapy;Physicians;Play;Population;Positioning Attribute;post stroke;Postdoctoral Fellow;Prevalence;prevent;Preventive Medicine;Protein Biosynthesis;Proteins;Pulmonology;Race;Radiology Specialty;Recommendation;Recording of previous events;rehabilitation paradigm;rehabilitation research;rehabilitation science;rehabilitation strategy;Rehabilitation therapy;Reporting;Research;research and development;Research Personnel;Rheumatology;Risk Reduction;Robotics;Role;sarcopenia;Science;Scientist;Seminal;Services;Side;Skeletal Muscle;Stroke;stroke rehabilitation;stroke survivor;Supplementation;symposium;tele-exercise;Testing;Thigh structure;Time;Tissues;Training;Training Programs;Translating;United States;United States Department of Veterans Affairs;United States National Institutes of Health;Universities;Veterans;weight maintenance;Work

PROJECT_TITLE: RR&D Research Career Scientist Award Application

STUDY_SECTION_NAME: Research Career Scientist[RRD7]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

ORG_STATE: CA

PHR: Project Narrative Cardiovascular diseases such as hypertension and atherosclerosis are among the major complications of diabetes that are associated with high morbidity and mortality, and therefore significant healthcare problems. This project will use state-of-the-art approaches to identify novel factors and mechanisms involved in the development of diabetic cardiovascular diseases, including those that persist even after glycemic control. The results could uncover much needed newer and better therapeutic targets to curb the development and progression of diabetes induced accelerated cardiovascular diseases, with significant clinical implications.

PI_NAMEs: NATARAJAN, RAMA  (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: 3-Dimensional;Acceleration;Adult;Affect;Angiotensin II;Aorta;Arteries;ATAC-seq;Atherosclerosis;Bioinformatics;Biological Assay;Blood Vessels;Candidate Disease Gene;Cardiovascular Diseases;cell behavior;cell dedifferentiation;Cell Separation;cell type;Cells;Chromatin;Clinical;Complications of Diabetes Mellitus;CRISPR/Cas technology;Data;db/db mouse;Development;diabetes management;Diabetes Mellitus;diabetic;diabetic cardiomyopathy;Diabetic mouse;DNA;DNA Methylation;Enhancers;epigenetic memory;Epigenetic Process;epigenome;epigenomics;Extracellular Matrix;Fibroblasts;Functional disorder;Funding;Genes;Genetic;Genome;genome-wide;genomic locus;Glucose;glycemic control;Growth Factor;Healthcare;Hi-C;Human;Hyperglycemia;Hypertension;improved;In Situ;In Vitro;in vivo;in vivo Model;Inflammation;Inflammatory;inhibitor;innovation;insight;Investigation;Knowledge;Losartan;Macrophage;Maps;Mediating;Memory;Metabolic;Methods;methylome;migration;Molecular Conformation;Morbidity - disease rate;mortality;multiple omics;Mus;new therapeutic target;novel;novel therapeutics;Patients;Pharmaceutical Preparations;Phenotype;Play;Production;programs;Receptor, Angiotensin, Type 1;RNA;Role;Signal Transduction;single cell ATAC-seq;single cell sequencing;single-cell RNA sequencing;Smooth Muscle Myocytes;Stimulus;Switch Genes;Synthetic Genes;Technology;Testing;therapeutic target;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;transcriptomics;translational potential;Type 2 diabetic;Untranslated RNA;Validation;Vascular Diseases;Vascular Smooth Muscle;vascular smooth muscle cell proliferation

PROJECT_TITLE: Transcriptional Regulation by Angiotensin II in Vascular Smooth Muscle Cells


ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

PHR: Following hospital discharge, risk of depression is significantly increased in cardio-vascular disease (CVD) patients. Moreover, CVD patients with depression face reduced functioning, increased morbidity and mortality, and diminished quality of life. Unfortunately, most depressed CVD patients do not receive appropriate evidence-based care for their depression, often because they are unable or hesitant to travel to VA providers for the regimen of 8-12 weekly visits of evidence-based psychotherapy such as Behavioral Activation (BA). We now propose to compare effectiveness, in terms of central outcomes of functioning, of BA for depression delivered via Home-based Telehealth- to standard post-CVD hospital discharge best-practices care in a 2x4 (treatment by time) repeated measures RCT crossover design (baseline, post-treatment, 3 & 9-month follow- up) with 132 depressed CVD Veteran patients.

PI_NAMEs: ACIERNO, RONALD E. (contact)

PROJECT_TERMS: actigraphy;Adult;Aftercare;Age;American;Anxiety;Behavioral;Cardiovascular Diseases;Caring;Clinic;comparative effectiveness;compare effectiveness;comparison group;cost;Cost Savings;Crossover Design;Data;Depressed mood;Disease;Effectiveness;Elderly;emotional symptom;Event;evidence base;Evidence based treatment;experience;Face;follow-up;Functional impairment;functional improvement;global health;Home;hospital readmission;Hospitalization;Hospitals;improved;Infrastructure;innovation;inpatient service;Intervention;Measures;Mental Depression;Modeling;Moods;Morbidity - disease rate;mortality;Outcome;Patients;Phase;Preventive measure;programs;promote resilience;Provider;Psychotherapy;Quality of life;Race;randomized, clinical trials;Recovery;Regimen;Research;Risk;Role;Secondary to;sex;social;standard care;standardize measure;Subgroup;telehealth;Testing;Time;Travel;treatment group;Veterans;Visit

PROJECT_TITLE: Behavioral Activation Delivered via Home-based Telehealth to Improve Functioning inCardiovascular Disease Patients Recently Discharged from Inpatient Care

STUDY_SECTION_NAME: Chronic Medical Conditions & Aging[RRD6]


ADMINISTERING_IC: AT

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dental, Oral, and Craniofacial Disease;Neurosciences;Opioids;Pain Research;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: PROJECT NARRATIVE This project examines, in chronic pain, the mechanisms of immersive virtual reality compared to the mechanisms of placebo hypoalgesia. The potential of developing new non-pharmacological premises for low-risk interventions for pain management is high.

PI_NAMEs: COLLOCA, LUANA  (contact)

PROGRAM_OFFICER_NAME: BELFER, INNA

PROJECT_TERMS: Absence of pain sensation;Acute;Adjuvant;Affect;antagonist;Anxiety;associated symptom;Behavioral Mechanisms;biobehavior;Brain;Categories;Chronic;chronic pain;chronic pain patient;Classification;Clinical;cognitive function;cohort;Collaborations;Consensus;Controlled Environment;COVID-19 pandemic;design;Devices;Diagnosis;disability;Ecological momentary assessment;Electroencephalography;empowerment;endogenous opioids;Esthetics;evidence base;experience;Frequencies;Future;General Population;Generations;Goals;Health Personnel;Immersion;improved;Individual;information processing;innovation;Intervention;intervention cost;knowledge of results;Maryland;Measurement;Measures;Methods;Modeling;Monitor;Moods;mu opioid receptors;multisensory;Naloxone;neural;neural information processing;neuromechanism;Nonpharmacologic Therapy;Normalcy;novel;Opioid;opioid epidemic;Orofacial Pain;Outcome;Pain;Pain management;Pain Measurement;pain outcome;pain reduction;Pain Threshold;Participant;Patients;Pattern;pharmacologic;Phenotype;placebo analgesia;Placebo Effect;Placebos;Population;predict clinical outcome;prospective;Proxy;Recording of previous events;Research;Research Personnel;Resolution;responders and non-responders;response;Rest;Risk;Role;Schools;Shapes;Site;standard of care;Stimulus;System;systematic review;Techniques;Technology;Telemedicine;Temporomandibular Joint Disorders;Therapeutic;Time;Universities;virtual reality;virtual reality environment;virtual reality intervention

PROJECT_TITLE: Neural Mechanisms of Immersive Virtual Reality in Chronic Pain

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative The development of the peripheral nervous system is critical for proper motor function and sensory perception; however, loss of polarity in mouse Schwann cells leads to defects in timely myelination and Remak bundle formation, which can contribute to peripheral neuropathies and neuropathic pain. By understanding the interaction between extrinsic cues, from the extracellular matrix, and the internal state of Schwann cells, this study will allow us to better understand how Schwann cells interact with their environment to regulate myelination and Remak bundle formation.

PI_NAMEs: LILLIS, MONIQUE  (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Academia;Address;Adult;Age;Ascorbic Acid;Axon;Basal lamina;basolateral membrane;Behavioral Assay;Binding;Binding Sites;Caliber;career;career development;Cell Communication;Cell Culture Techniques;Cell Maintenance;Cell Maturation;Cell Physiology;Cell Polarity;Cell secretion;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Co-Immunoprecipitations;Collagen Receptors;Collagen Type IV;Complex;Cues;Cyclic AMP-Dependent Protein Kinases;Cytoskeleton;Data;Defect;Demyelinating Diseases;Development;Developmental Delay Disorders;Doctor of Philosophy;Educational workshop;Electron Microscopy;Environment;Epithelial Cells;Exons;Experimental Designs;experimental study;Extracellular Matrix;Extracellular Space;Extracellular Structure;G-Protein-Coupled Receptors;Genes;Goals;Health;Immunofluorescence Immunologic;In Vitro;in vivo;insight;Integrin alpha2;Integrins;intercalation;Knock-out;Laboratories;Learning;loss of function;LoxP-flanked allele;Manuscripts;Mediating;Membrane;molecular sequence database;Morphology;Motor;Mus;mutant;Mutation;myelination;Neuroglia;Neurosciences;novel;painful neuropathy;PAWR gene;Perception;Peripheral Nerves;Peripheral Nervous System;Peripheral Nervous System Diseases;Phenocopy;Phenotype;polarized cell;posters;prevent;Primary Cell Cultures;Principal Investigator;Process;programs;Protein Biochemistry;Proteins;Publishing;receptor;recruit;Research;Role;Schwann Cells;sciatic nerve;Sensory;Signal Transduction;skill acquisition;Specific qualifier value;STK11 gene;Techniques;tenure track;Testing;Training;Viral;Western Blotting;Work;Writing

PROJECT_TITLE: The role of the extracellular matrix in establishing Schwann cell polarity


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Gene Therapy;Genetics;Immunotherapy;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE T cell-based immunotherapy is an emerging class of treatment that has produced remarkable results for certain types of cancers. However, the current process of manufacturing individualized cellular therapies produces inconsistent clinical responses and is costly and difficult to coordinate with clinical care. Our proposed studies will enable the use of stem cell technologies to generate a more abundant and effective source of cancer specific T cell therapies.

PI_NAMEs: YOO, SANG PIL  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: 3' Untranslated Regions;3-Dimensional;Address;Affect;Allogenic;Antigens;Autologous;Biological;cancer type;CAR T cell therapy;CD19 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Maturation;Cell Therapy;Cells;Cellular biology;Cellular immunotherapy;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;clinical care;constitutive expression;cost;CRISPR/Cas technology;cytotoxicity;Data;Development;Engineering;Excision;gene editing technology;Generations;Genes;Genetic;Genetic Transcription;graft vs host disease;Granzyme;Health Services Accessibility;Hematologic Neoplasms;human pluripotent stem cell;Immunoglobulin Constant Region;Immunotherapy;improved;In Vitro;in vivo;individualized medicine;induced pluripotent stem cell;innovation;interest;Lymphoid;Malignant Neoplasms;manufacturing process;Mature T-Lymphocyte;Methods;Modeling;monolayer;multipotent cell;novel;Organoids;Pathway interactions;Patients;Pattern;Physiological;Positioning Attribute;prevent;Receptor Cell;receptor expression;Receptor Signaling;receptor-mediated signaling;Refractory;Research;response;Risk;Signal Transduction;Source;stem cell technology;stem cells;System;T cell differentiation;T cell therapy;T-Cell Development;T-Cell Receptor;T-Lymphocyte;Thymus Gland;transcriptome sequencing;Transgenes;Tumor Antigens

PROJECT_TITLE: Engineering detours around the biologic barriers to allogeneic, iPSC-derived CAR T immunotherapy


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_DEPT: NEUROSCIENCES

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: Project Narrative We will use an interdisciplinary approach to examine how the activity of prefrontal astrocytes adapts from the onset of heroin use to habitual seeking and relapse. We will determine how astrocytes incorporate into the neural network to coordinate neuronal ensemble dynamics and heroin-seeking behavior. Results will identify astrocytes as a novel cell population that can be targeted to disrupt heroin-conditioned associations, reducing relapse vulnerability in patients suffering from opioid use disorder.

PI_NAMEs: PANICCIA, JACQUELINE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: BABECKI, BETH

PROJECT_TERMS: Astrocytes;Automobile Driving;Behavior;behavioral outcome;Behavioral Paradigm;Calcium;calcium indicator;Cells;Characteristics;Coupled;Cue-induced relapse;Cues;Data;Development;Dorsal;drug seeking behavior;Drug usage;Environment;Event;excitatory neuron;experimental study;Exposure to;Extinction;Genetic;genetic approach;Goals;Growth;Head;Heroin;heroin use;Image;in vivo;in vivo calcium imaging;in vivo two-photon imaging;Individual;interdisciplinary approach;Knowledge;Label;Laboratories;Measurement;Measures;Medial;Membrane;Mentorship;Methods;Mus;neural circuit;neural network;Neuroglia;neuromechanism;neuronal circuitry;Neurons;novel;novel therapeutic intervention;Nucleus Accumbens;opioid epidemic;opioid use disorder;Patients;Pattern;Pharmaceutical Preparations;Population;Prefrontal Cortex;Publishing;receptor;Regulatory Element;Relapse;Research Personnel;Resolution;response;restraint;Saline;Self Administration;Stimulus;Technical Expertise;Testing;tool;Training;training opportunity;two photon microscopy;two-photon;Virus;Visualization;Work

PROJECT_TITLE: Characteristics and Function of Prefrontal Astrocyte Activity in Heroin-Seeking Behavior


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: PROJECT NARRATIVE The Institute of Medicine’s report “The Health of Lesbian, Gay, Bisexual, and Transgender (LGBT) People,” published in 2011, called for the development of evidence-based and rigorous research aimed at understanding the health implications of hormone use in transgender individuals. The goal of the proposed research is to extend follow-up data collection over an additional 4 years for this multi-site, observational study examining the physiological and psychosocial outcomes of existing medical treatment protocols for gender dysphoria in two cohorts: early pubertal and late pubertal transgender and gender diverse youth. Results from this study have the potential to significantly impact the medical and mental health services provided to transgender and gender diverse youth in the U.S. by making available rigorous scientific evidence outlining the longer-term impact and safety of early treatments based on pubertal development stage.

PI_NAMEs: CHAN, YEE-MING ;GAROFALO, ROBERT ;OLSON-KENNEDY, JOHANNA L (contact);ROSENTHAL, STEPHEN M

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Adolescence;Adolescent;Adolescent Development;Age;Anxiety;assigned male at birth;Award;Behavioral;Birth;Blood Pressure;bone health;Boston;California;cardiovascular risk factor;Cardiovascular system;Caring;Chicago;Child;children of color;Clinical;clinical care;Clinical Management;Clinical Practice Guideline;cohort;Data;Data Collection;demographics;Development;Early treatment;emerging adult;Enrollment;Estrogens;Ethnic Origin;evidence base;family support;Female;Feminization;follow-up;Funding;gender affirming hormone therapy;gender affirming hormones;gender affirming intervention;gender diverse;gender dysphoria;gender minority group;gender minority stress;Goals;Gonadal Steroid Hormones;Gonadotropin-Releasing Hormone Analog;Grant;Health;Height;HIV;Hormone use;improved;Individual;Institute of Medicine (U.S.);Intervention;Investments;LGBT Health;Lipids;Los Angeles;male;Masculine;Measurement;Measures;Medical;medical schools;Mental Depression;Mental Health;Mental Health Services;Metabolic;minority children;Modeling;multidisciplinary;nonbinary;Not Hispanic or Latino;Obesity;observational cohort study;Observational Study;Outcome;Parents;Pediatric Hospitals;peer;Persons;Physiologic calcification;Physiological;Population;Positioning Attribute;preadolescence;prospective;Psyche structure;psychologic;Psychological Impact;psychosocial;Psychosocial Factor;psychosocial outcome;psychosocial wellbeing;Puberty;puberty blocker;Public Health;Publishing;Quality of life;racial minority;Recording of previous events;recruit;Reporting;Research;resilience;response;Risk;Safety;Sampling;San Francisco;Services;sex assigned;side effect;Site;Subgroup;substance use;Suicide;Testosterone;Time;transfeminine;transgender;Treatment Protocols;Treatment/Psychosocial Effects;trend;United States;United States National Institutes of Health;Universities;Weight;Youth

PROJECT_TITLE: The Impact of Early Medical Treatment in Transgender Youth

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Cancer;Clinical Research;Contraception/Reproduction;Estrogen;Fibroid Tumors (Uterine);Women's Health Research

ORG_CITY: NEW HAVEN

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Uterine fibroids (leiomyomas) are remarkably common, benign tumors of the uterus that are a significant threat to women's health. Uterine fibroids are characterized by unregulated proliferation, which we found to be promoted by glucocorticoid signaling. The overall goal of this proposal is to determine the molecular mechanisms by which glucocorticoids regulate uterine fibroid growth and proliferation, including cross-talk with the ovarian hormone receptors.

PI_NAMEs: WHIRLEDGE, SHANNON D (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: Age;Benign;Biological Availability;Cell Proliferation;cell type;Cells;ChIP-seq;Co-Immunoprecipitations;cofactor;Common Neoplasm;Data;Endometrial Neoplasms;enzyme activity;Estrogen Receptors;Estrogens;experimental study;Female Genital Diseases;Female Genital Neoplasms;Fibroid Tumor;Functional disorder;functional plasticity;Gene Expression;Genes;Genetic Transcription;Genomic Segment;Glucocorticoid Receptor;Glucocorticoids;Goals;Gonadal Steroid Hormones;Growth;Growth and Development function;Gynecologic;Hormone Receptor;Hydrocortisone;Hysterectomy;innovation;Investigation;knock-down;Leiomyoma;Ligands;Mammary Neoplasms;Mass Spectrum Analysis;Mediating;Medical;Molecular;Mus;Myometrial;myometrium;novel;novel therapeutic intervention;Ovarian hormone;Parents;Pathogenesis;Pathologic;Pathway interactions;Phosphorylation;Physiological;Post-Translational Protein Processing;Prevalence;Process;Progesterone;Progesterone Receptors;Prognosis;Proliferating;Protein Isoforms;receptor;Receptor Activation;receptor binding;Receptor Cross-Talk;receptor expression;receptor function;Regulation;reproductive;response;Severities;Signal Transduction;Signaling Molecule;steroid hormone;steroid hormone receptor;Steroid Receptors;Symptoms;targeted treatment;Testing;Therapeutic;therapy development;Tissues;transcriptome sequencing;transcriptomics;tumor;tumor growth;United States;Uterine Fibroids;Uterine Neoplasms;Uterus;Woman;Women's Health;Work

PROJECT_TITLE: Steroid Receptor Crosstalk and Pathogenesis of Uterine Fibroids

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Cardiovascular;Hypertension

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Arterial smooth muscle is responsible for vascular tone and is therefore a major contributor to blood flow and pressure regulation in vascular health and disease. Derangements in Notch signaling result in smooth muscle dysfunction and genetic mutations in the signaling pathway are associated with human syndromes featuring stroke and vascular anomalies. This project serves to uncover novel molecular mechanisms through which Notch signaling regulates arterial vasoreactivity and hemodynamics and to provide the foundation for Notch- targeted pharmacologic therapies for treatment of arterial hypertensive disease, thereby informing our understanding of basic mechanisms of vascular physiology.

PI_NAMEs: PROWELLER, AARON  (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Acute;Adult;Animal Disease Models;Animals;Arteries;Biological Assay;Blood flow;Blood Pressure;blood pressure regulation;Blood Vessels;cardiovascular risk factor;Cell Communication;Cell Compartmentation;Chronic;Clinical;Coupled;desensitization;Development;Dilator;Disease;DNA Sequence Alteration;Endothelial Cells;Endothelium;Enzymes;Equilibrium;Exhibits;Foundations;Functional disorder;Gene Expression;Generations;Goals;Health;hemodynamics;Human;Hypertension;Hypotension;Impairment;In Vitro;in vivo;Instruction;Knowledge;Laboratories;Left;Ligands;loss of function;Measures;Mediating;Molecular;Molecular Profiling;Morbidity - disease rate;mortality;mouse model;Mus;Muscle function;Myography;Myosin ATPase;Myosin Light Chain Kinase;Myosin Light Chains;myosin phosphatase;notch protein;novel;novel therapeutic intervention;Pathway interactions;Peripheral;pharmacologic;Phenotype;Phosphorylation;Phosphotransferases;Physiologic intraventricular pressure;Physiological;Physiology;Post-Translational Protein Processing;pressure;Production;Protein Dephosphorylation;receptor;receptor function;Regulation;Relaxation;Resistance;response;Role;Second Messenger Systems;Sepsis;Signal Induction;Signal Pathway;Signal Transduction;Smooth Muscle;Smooth Muscle Myocytes;Smooth Muscle Myosins;Stimulus;Stroke;Syndrome;Systemic blood pressure;Testing;Therapeutic;transmission process;Vascular Diseases;Vascular resistance;Vascular Smooth Muscle;vasoconstriction;Vasodilation

PROJECT_TITLE: Arterial Vasoregulation by Notch Signaling

STUDY_SECTION: VCMB

STUDY_SECTION_NAME: Vascular Cell and Molecular Biology Study Section[VCMB]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative: Acute and chronic liver diseases contribute to substantial morbidity, mortality and healthcare costs, and research to understand, diagnosis, prevent and treat liver conditions is critically important to improve human health. This postdoctoral training program for adult and pediatric gastroenterology fellows (MD or MD/PhD) will provide basic-translational or clinical-translational training pathways in hepatology research with rigorous training and robust mentorship in support of the next generation of physician–scientists.

PI_NAMEs: KOHLI, ROHIT ;TERRAULT, NORAH A. (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TITLE: Translational Research Training in Hepatology


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Precision Medicine;Prevention;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative Sex differences in the development and prevalence of mental illnesses are widespread, suggesting that the risk factors that promote disease susceptibility may be distinct in men and women. This project explores the neurobiological basis of divergent (active vs. passive) fear responses in males and females, which could help identify novel ways to prevent or treat post-traumatic stress disorder.

PI_NAMEs: SHANSKY, REBECCA M (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: Amygdaloid structure;Anatomy;Animal Experimentation;Aversive Stimulus;Behavior;Behavioral;behavioral outcome;behavioral response;Clinical;cohort;Complex;conditioned fear;Conditioned Reflex;conditioning;coping;Crete;Data;Development;Disease;Disease susceptibility;disorder risk;Dorsal;Equilibrium;Exhibits;Extinction;Female;flexibility;FOS gene;Freezing;Fright;Genetic;genetic approach;Goals;Immunofluorescence Immunologic;improved;Individual Differences;insight;Investigation;Learning;Link;Machine Learning;machine vision;male;Measures;Mediating;Mediator;men;Mental disorders;midbrain central gray substance;Modeling;neural;neural circuit;neurobiological mechanism;Neurobiology;novel;Odors;Outcome;Outcome Measure;Pain;Pattern;Performance;pharmacologic;Phenotype;Post-Traumatic Stress Disorders;postsynaptic;pre-clinical;Pre-Clinical Model;Prediction of Response to Therapy;predictive marker;Prevalence;prevent;Rattus;recruit;resilience;response;Risk Factors;Risk Marker;Role;selective expression;sex;Sex Differences;sexual dimorphism;Shock;Stimulus;Stress;stress resilience;success;Synapses;Techniques;Testing;tool;translational goal;translational neuroscience;trauma exposure;Viral;Woman;Women's prevalence;Work

PROJECT_TITLE: Infralimbic circuit control over a sex-dependent switch in threat responding

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: It is very difficult to treat the severe disabilities observed among Veterans with Severe Mental Illness (SMI), such as Schizophrenia, Schizoaffective Disorder and Bipolar 1 Disorder. These Severe Mental Illnesses affect thousands of Veterans; they are also associated with impairment in community (social) functions that increases the burden of suffering to Veterans and their families. Current treatment for the impairment is inadequate. We propose systematic studies to study simplified, non-religious Yoga exercises as a rehabilitation tool for Veterans with SMI. We will also study the characteristics of Veterans who are more likely to accept and adopt Yoga exercises over 12 months, and the barriers they encounter. Our aims are well-aligned with the VA Secretary’s priorities, the VA Strategic Plan, the MISSION Act and the Whole-Health Wellness approaches promoted by the VHA Office of Mental Health and Suicide Prevention.

PI_NAMEs: HAAS, GRETCHEN L;NIMGAONKAR, VISHWAJIT LAXMIKANT (contact)

PROJECT_TERMS: 2 arm randomized control trial;Adopted;Adoption;Affect;alcohol use disorder;Area;arm;Award;Bipolar I;Breathing Exercises;Characteristics;Clinic;Clinical;Cognition;cognitive benefits;Cognitive deficits;Communities;Community Integration;comorbidity;comparative efficacy;Complementary Medicine;Consent;Consolidated Framework for Implementation Research;Consult;cost;COVID-19;COVID-19 pandemic;Data;design;disability;Disease;effectiveness/implementation study;efficacy study;Elements;Employment;Ensure;Exercise;exercise intervention;exercise program;exercise training;experience;Family;Frequencies;future implementation;Goals;Health;Health Personnel;Healthcare;Home;Hybrids;Impaired cognition;Impairment;implementation efforts;implementation facilitators;improved;India;Individual;ineffective therapies;instructor;Integrative Medicine;interest;Intervention;Interview;Leisures;Life;Life Style;long-term rehabilitation;Measures;Mental Health;mindfulness;Mission;Muscle Contraction;Outcome;Participant;Patient Self-Report;Patients;Pattern;performance based measurement;Persons;Pharmaceutical Preparations;Physical Fitness;physically handicapped;Pilot Projects;Population;Post-Traumatic Stress Disorders;Posture;Prevalence;primary outcome;programs;Protocols documentation;Publishing;Quality of life;Randomized;Randomized, Controlled Trials;Recording of previous events;Refractory;Regulation;Rehabilitation therapy;Relaxation;Research;Research Design;Role;Rural Community;Safety;Schedule;Schizoaffective Disorders;Schizophrenia;secondary outcome;Services;severe mental illness;skills;social;Social Functioning;Socialization;Strategic Planning;Stretching;study characteristics;Substance Use Disorder;Suicide prevention;Symptoms;Techniques;Testing;Time;tool;Training;treatment arm;treatment as usual;uptake;Veterans;virtual;whole health;Yoga

PROJECT_TITLE: Exercise-based Program for Rehabilitation of Veterans with Severe Mental Illness

STUDY_SECTION_NAME: Behavioral Health & Social Reintegration[RRD4]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE (Relevance) Negatively biased thought is candidate transdiagnostic process relevant to a number of mental health disorders. We will establish a neural assay for negatively biased thought in mice, validate this assay pharmacologically and probe its connection with dopamine.

PI_NAMEs: VAN DER MEER, MATTHIJS  (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: Address;Affect;Affective;Amphetamines;Animal Behavior;Animals;Behavior;Behavioral;Belief;Biological Assay;clinical translation;cognitive process;comorbidity;Decision Making;Development;Dextroamphetamine;Diagnostic;Disease;Dopamine;Dopaminergic Agents;Equilibrium;Event;expectation;experience;experimental study;Failure;Future;Generalized Anxiety Disorder;Generations;Hippocampus;Human;Individual;information processing;Laboratory Animals;Learning;Link;Major Depressive Disorder;Mammals;Mediating;Memory;memory retrieval;Mental disorders;Mood Disorders;Moods;Motivation;Mus;neural;neural circuit;Outcome;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Post-Traumatic Stress Disorders;pramipexol;pre-clinical;Process;Proliferating;response;Retrieval;Rewards;Rodent;Schizophrenia;Signal Transduction;success;Syndrome;System;Testing;theories;Translating;translational potential;Validation;Ventral Striatum;Work

PROJECT_TITLE: Biases in sharp wave-ripple content as a transdiagnostic cognitive process

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Narrative Intestinal humoral response occurs in an environment exposed to multiple metabolic stimuli, from both diet and commensal bacteria. We identified the transcription factor SREBP2 as a potential key regulator of germinal center response. Oxysterols, oxidized forms of cholesterol, have been shown to control SREBP2 activation and transcription activity. This proposal aims to identify the mechanisms by which SREBP2 shapes germinal center B cell differentiation in antibody-secreting plasma cells and to map oxysterol niche and its extrinsic requirements. Thus, insight into the oxysterols-SREBP2 axis during germinal center B cell differentiation and into the cellular and environmental regulation of oxysterol production, will be generated from this proposal.

PI_NAMEs: REBOLDI, ANDREA  (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: 16S ribosomal RNA sequencing;25-hydroxycholesterol;Adaptive Immune System;adaptive immunity;Antibiotics;Antibodies;Antibody Formation;Antibody Response;Antigens;Area;B cell differentiation;B Cell Proliferation;B-Cell Activation;B-Lymphocytes;Bacterial Antigens;Bile Acids;Binding Proteins;Biological Assay;Biological Availability;Biological Process;Cell Fate Control;Cells;Cholesterol;cholesterol absorption;Cholesterol Homeostasis;Clone Cells;commensal bacteria;Complex;Couples;Cues;Data;Diet;dietary;Dietary Cholesterol;Dietary Intervention;dietary manipulation;draining lymph node;Environment;expectation;Exposure to;Follicular Dendritic Cells;Foundations;Gastrointestinal tract structure;Gene Expression Profile;Generations;Genes;Genetic Transcription;Helper-Inducer T-Lymphocyte;Homeostasis;Immune;Immune system;Immunology;Impairment;in vivo;Individual;insight;Intervention;intestinal homeostasis;Intestines;Lead;Link;lipid biosynthesis;lipid metabolism;Lipids;liquid chromatography mass spectrometry;lymph nodes;machine learning method;Maintenance;Maps;Mediating;Memory B-Lymphocyte;Metabolic;Metabolism;Microanatomy;microbial;microbiome;microorganism antigen;Modeling;Molecular;Mus;Nature;novel;Output;oxysterol binding protein;Pathway interactions;Peripheral;pharmacologic;Phenocopy;plasma cell differentiation;Plasma Cells;Play;prevent;Process;Production;Reaction;Reagent;Regulation;resident commensals;response;Response Elements;Role;Shapes;Source;Spleen;Sterols;Stimulus;Stromal Cells;Structure of germinal center of lymph node;Testing;transcription factor;Transcriptional Regulation;transcriptome sequencing;Work

PROJECT_TITLE: Diet-derived oxysterols shape intestinal B cell fate by controlling intracellular cholesterol metabolism

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Eye Disease and Disorders of Vision;Neurosciences;Rehabilitation

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE Within a decade, many blind individuals are likely to be offered a wide range of options for sight restoration - including electronic prostheses, gene therapy and optogenetics. However the vision provided by almost all of these technologies will differ substantially from normal sight. The question of this proposal is – What role can cortical plasticity play in helping patients make use of the artificial visual input provided by sight recovery technology?

PI_NAMEs: BOYNTON, GEOFFREY M;FINE, IONE  (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Accommodation phosphene;Adult;Animal Model;Architecture;Axon;Biological;Brain;Cells;Clinical Trials;Code;Compensation;Computer Models;Data;design;Development;Device Designs;Devices;Electrodes;Electronics;experience;Eye;Eye Movements;fovea centralis;Fruit;ganglion cell;gene therapy;Gene therapy trial;Goals;Human;human data;Implant;Individual;infancy;insight;Kinetics;Learning;Leber's amaurosis;Light;Manufacturer;Modeling;Motion;neural;Neurons;neurophysiology;novel;Ocular Dominance;Ocular dominance columns;Ocular Prosthesis;Optic Nerve;optogenetics;Participant;Patients;Perceptual learning;Physiological;Play;Population;Prosthesis;Psychophysics;receptive field;Recovery;Reporting;Research;Resolution;response;Retina;retina implantation;Retinal Ganglion Cells;retinal stimulation;Role;Route;sight restoration;spatiotemporal;Surface;Technology;Testing;Thinking;Training;Video Games;virtual patient;Vision;Visual;Visual Perception;Visually Impaired Persons;Work

PROJECT_TITLE: Learning to see again: biological constraints on cortical plasticity and the implications for sight restoration technologies

STUDY_SECTION: SPC

STUDY_SECTION_NAME: Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section[SPC]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Data Science;HIV/AIDS;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: PORTLAND

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: Project Narrative The Oregon Health & Science University (OHSU) National Library of Medicine (NLM) T15 Biomedical Informatics Training Program trains future researchers and leaders in biomedical and health informatics, the field devoted to improving personal health, health care, public health, and biomedical research through the use of data, information, and their associated technologies. This NLM Training Grant will enable us to support predoctoral (PhD students) and postdoctoral trainees pursuing courses, an in-depth research project, and related academic activities. This proposal is a competitive renewal for a seventh five-year cycle of funding for the OHSU program, which has been a leader and innovator in the program for three decades.

PI_NAMEs: HERSH, WILLIAM R;MOHAN, VISHNU  (contact)

PROGRAM_OFFICER_NAME: BINGHAM, CLAYTON SCOTT

PROJECT_TERMS: Area;biomedical informatics;Biomedical Research;career;clinical epidemiology;Data Science;design;Doctor of Philosophy;doctoral student;Education;Ensure;equity, diversity, and inclusion;Evaluation;experience;Faculty;Funding;Future;Grant;Health;Healthcare;HIV;Human;improved;Individual;Informatics;Leadership;Machine Learning;Master of Science;Medical Informatics;Oregon;Postdoctoral Fellow;pre-doctoral;programs;Public Health;Publications;Research;Research Personnel;Research Project Grants;Research Training;Resources;Science;Students;success;theories;Training;Training Programs;Translations;United States National Library of Medicine;Universities

PROJECT_TITLE: Research Training in Biomedical Informatics and Data Science at Oregon Health & Science University


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Methamphetamine;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: ROCHESTER

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative Astrocytes and the glial progenitors from which they derive are the most abundant cells in the human CNS, and modulate both the structure and function of neural networks; they are also potential reservoirs of CNS HIV infection, which is itself associated with deficits in cognition that may both persist and progress, despite optimal control of systemic infection. Nonetheless, because of HIV1's phenotype-specific and species- selective virulence, it has been difficult to study human HIV1 infection, or its associated neurocognitive disorder, in animal models in vivo. To address this issue, we propose to use mice neonatally-transplanted with human ESC-derived glial progenitor cells and microglia - in which most host glial progenitors, and a large fraction of astrocytes and microglia, are ultimately replaced by human cells - to assess the effects of striatal HIV1 infection – with and without chronic exposure to methamphetamine, a common drug of abuse in HIV - on human astroglia, and ultimately on the structure, transcription and behavioral output of striatal neurons in the HIV1-infected brain.

PI_NAMEs: GOLDMAN, STEVEN ALAN (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: addiction;Address;Adult;Affect;Amphetamine Abuse;Anatomy;Animal Experiments;Animal Model;Animals;Architecture;Astrocytes;Autopsy;Behavior;Behavior assessment;Behavioral;Blood Vessels;Brain;brain cell;Categories;Cells;Central Nervous System;Chimera organism;Chronic;Cognition;Cognitive;Cognitive deficits;cognitive enhancement;Communicable Diseases;comorbidity;Corpus striatum structure;CSF1R gene;defined contribution;Dendrites;density;Deterioration;Development;Disabling;drug of abuse;embryonic stem cell;Engraftment;Environment;Event;Fiber;Functional impairment;Gene Expression;Gene Expression Profile;Genetic Transcription;glial activation;Goals;HIV;HIV Infections;HIV-1;HIV-associated neurocognitive disorder;Hominidae;Human;human embryonic stem cell;humoral immunity deficiency;Immune;Immunodeficient Mouse;implantation;in vivo;in vivo Model;Infection;Knockout Mice;Light;Lymphocyte;Macrophage;Maps;methamphetamine exposure;methamphetamine use;Methods;Microglia;Modeling;monocyte;mouse model;Mus;Nature;Neonatal;neonatal mice;Neostriatum;neural network;neurocognitive disorder;Neurodegenerative Disorders;Neuroglia;Neurons;neurophysiology;Neurophysiology - biologic function;Oligodendroglia;Output;Pathology;Phenotype;Pleomorphism;Process;progenitor;Rabies;response;Rewards;Role;Secondary to;single-cell RNA sequencing;stem cells;Structure;Synapses;synaptic failure;synaptic function;Systemic infection;T-Lymphocyte;Techniques;Testing;Time;Toxic effect;trafficking;Transplantation;Vertebral column;Viral;Virulence;Virus;Xenograft procedure

PROJECT_TITLE: A DUAL CHIMERIC HUMAN ASTROGLIAL-MICROGLIAL MODEL OF HIV AND HAND


ORG_CITY: SALT LAKE CITY

ORG_NAME: VA SALT LAKE CITY HEALTHCARE SYSTEM

ORG_STATE: UT

PHR: The research in this CDA-2 proposal is highly relevant to Veteran Health, because heart failure with preserved ejection (HFpEF) disproportionately affects Veterans and is the number one reason for hospital discharge in the VA Health Care System. Exercise intolerance, a predictor of mortality risk, is a common complication experienced by patients with HFpEF, perpetuating physical inactivity and accelerating disease progression. This research proposal will address this fundamental gap in knowledge by elucidating peripheral vascular control mechanisms (i.e., autonomic and vascular function) that underlie inadequate skeletal muscle blood flow, thereby contributing to exercise intolerance, as well as evaluating the efficacy of a novel knee extensor exercise training intervention to improve this aspect of HFpEF pathophysiology. Such improved understanding in HFpEF pathophysiology is a critical step towards identification of potential therapeutic targets and exercise-based rehabilitation strategies that may lead to improved quality of life and patient care.

PI_NAMEs: BUNSAWAT, KANOKWAN  (contact)

PROJECT_TERMS: Acceleration;Activities of Daily Living;Acute;Address;Aerobic Exercise;Affect;American;Attenuated;attenuation;Autonomic Dysfunction;Autonomic nervous system;Award;Blood flow;Blood Vessels;Cardiac;Cardiopulmonary;career;Characteristics;Chronic Phase;Clinical;clinical practice;comparison control;Complex;Complication;Data;Disease;Disease Progression;Educational Intervention;efficacy evaluation;EFRAC;Exercise;exercise intolerance;Exercise Physiology;exercise rehabilitation;Exercise Therapy;Exercise Tolerance;exercise training;Exhibits;experience;Extensor;Functional disorder;functional restoration;Goals;Health;Healthcare Systems;Heart failure;heart function;high risk;Hospitalization;Hospitals;Impairment;improved;improved outcome;insight;interest;Knee;Knowledge;Limb structure;Link;Lower Extremity;Mediating;Medicine;Mentorship;Metabolic;Modality;Modeling;mortality;mortality risk;muscle form;Natural History;neural;neurovascular;Nitric Oxide;novel;Outcome;Patient Care;Patients;Peripheral;Pharmacotherapy;Phase;Phenotype;Physical activity;Physical Exercise;physical inactivity;preservation;Quality of Care;Quality of life;readmission rates;Regulation;rehabilitation strategy;Rehabilitation therapy;Reporting;Research;Research Personnel;Research Proposals;response;restraint;Role;Scientist;skeletal;Skeletal Muscle;skills;Stress;Survival Rate;Symptoms;Testing;Therapeutic;therapeutic target;Training;United States National Institutes of Health;Vascular Diseases;Vasodilation;Veterans;Walking

PROJECT_TITLE: Mechanisms of Impaired Skeletal Muscle Blood Flow and Exercise Intolerance in Veterans with Heart Failure with Preserved Ejection Fraction:  Efficacy of Knee Extensor Training

STUDY_SECTION_NAME: Career Development Program - Panel II[RRD9]


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Organ Transplantation;Pediatric;Transplantation

ORG_CITY: CHICAGO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Our goal is to develop multiparametric cardiac MRI and automated deep learning based cardiac MRI analysis workflows for improved assessment for complications after heart transplantation, the treatment of choice for many patients with end-stage heart failure. Cardiac MRI will be developed to allow for efficient application from pediatric to adult patients in order to evaluate its diagnostic value for non-invasively detecting complications and to investigate the impact of differences in heart donor and recipient characteristics on the performance of the transplanted heart. In addition, we will leverage an existing large cardiac MRI database to allow for long-term 5-year follow-up to establish new measures for improved outcome prediction and therapy management in heart transplant recipients.

PI_NAMEs: CARR, JAMES ;MARKL, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: Acute;Address;Adult;adverse outcome;Age;Algorithms;Allografting;analysis pipeline;Angiography;automated analysis;Biopsy;Body mass index;Cardiac;cardiac magnetic resonance imaging;Catheters;Cause of Death;Cessation of life;Characteristics;Child;Childhood;Cicatrix;Clinical;cohort;cost;Data;Databases;deep learning;diagnostic value;Diffuse;Disease Progression;Donor Selection;Early Diagnosis;Edema;Event;extracellular;Failure;Fibrosis;flexibility;follow-up;Follow-Up Studies;Functional disorder;Funding;Gender;Goals;graft dysfunction;graft failure;health care service utilization;Heart;Heart Abnormalities;heart allograft;heart dimension/size;Heart failure;heart function;Heart Rate;Heart Transplantation;Height;Hospitalization;Hypertension;Image;imaging biomarker;improved;improved outcome;Inflammation;insight;interstitial;Label;Left;Life;Link;Longterm Follow-up;Magnetic Resonance Imaging;Maps;Measures;Methodology;Modeling;Monitor;mortality;Motion;Myocardial;Myocardial tissue;Natural History;Nature;Non-Invasive Detection;non-invasive imaging;novel;Outcome;outcome prediction;Outcome Study;Patient-Focused Outcomes;Patients;Pattern;pediatric patients;Performance;Phase;Physiological;Physiology;Population;Prevalence;Procedures;Prospective Studies;Protocols documentation;Resolution;Right Ventricular Dysfunction;Risk Factors;Role;Sampling Errors;Severities;sex;Sex Differences;Smoking;spatiotemporal;standard of care;Structure;Testing;Time;tissue biomarkers;Tissue Grafts;Tissues;Training;transplant database;Transplant Recipients;Transplantation;Transplantation Surgery;Transplanted Heart Complication;treatment choice;Vascular Diseases;Ventricular;Vulnerable Populations;Weight

PROJECT_TITLE: Comprehensive Cardiac Structure-Function Analysis in Heart Transplantation

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]