NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative Nucleophosmin mutations (NPM1c) are among the most common aberrations in acute myeloid leukemia, however, the mechanism of action is poorly understood and there is a desperate need for targeted treatment options. We recently uncovered a novel link between NPM1c and the MLL histone methyltransferase complex through the use of Menin-MLL interaction inhibitors, which are able to reverse leukemic self-renewal programs. In this study we seek to define the chromatin changes induced by mutant NPM1c and how it employs the MLL complex to regulate leukemic self-renewal.

PI_NAMEs: ARMSTRONG, SCOTT A (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Myelocytic Leukemia;Adaptor Signaling Protein;Architecture;Binding;Biological Availability;Cell Survival;Cells;Chromatin;Chromatin Remodeling Factor;Co-Immunoprecipitations;cofactor;Complex;Cytogenetics;Data;Dependence;Development;Early identification;Epigenetic Process;epigenetic regulation;epigenetic therapy;Future;Gene Activation;Gene Cluster;Gene Expression;Gene Expression Profile;Genes;Goals;High Prevalence;histone methyltransferase;human model;improved;in vivo;inhibitor;insight;Knock-out;leukemia;Leukemic Cell;leukemic transformation;leukemogenesis;Link;MEIS1 gene;Menin;MLL gene;MLLT2 gene;Molecular;mouse model;mutant;Mutate;Mutation;novel;nucleophosmin;Oral;Phase I Clinical Trials;Process;programs;Proliferating;promoter;Proteins;recruit;Research;Research Project Grants;Role;self-renewal;Site;small molecule inhibitor;stemness;Subgroup;targeted treatment;Tertiary Protein Structure;Therapeutic;Therapeutic Effect;therapeutic target;Transcription Coactivator;Transcriptional Regulation;treatment strategy;Up-Regulation

PROJECT_TITLE: Defining epigenetic mechanisms in NPM1c mutant leukemia

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Neurosciences

ORG_CITY: Aurora

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: The proposed research seeks to engineer new approaches using light and light-responsive proteins to conditionally regulate protein function and sense dynamic protein activity states. The outcome of this work will be highly precise genetic tools activated by light that scientists can use to probe, query, and better understand cellular processes relevant to health and disease.

PI_NAMEs: TUCKER, CHANDRA L (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Area;Biochemical Process;Biological;Biological Process;Cell Physiology;Cells;cryptochrome 2;Disease;Engineering;engineering design;Environment;Genetic;Goals;Health;Imaging technology;improved;Light;novel;novel strategies;optogenetics;Outcome;Photoreceptors;Plant Photoreceptors;protein complex;Protein Dynamics;Protein Engineering;protein function;Proteins;Regulation;Research;Scientist;Testing;Time;tool;Work

PROJECT_TITLE: Uncovering new approaches to manipulate and probe biochemical processes with spatial and temporal precision.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(55)R]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: AUGUSTA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is providing funds to establish the coordinating unit (CU) for the Innovative Science Accelerator (ISAC) Program. The CU will coordinate the interactions of the ISAC awardees, provide financial management for opportunity pool programs, interact with the NIDDK Program Officers and External Expert Panel, support the annual ISAC scientific meetings as well as provide a national web portal for ISAC in order to disseminate information and provide an organizational infrastructure for the program. This application will provide the infrastructure for the CU for ISAC.

PI_NAMEs: MCINDOE, RICHARD A. (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Acceleration;Agreement;analytical tool;Area;Award;Businesses;Collaborations;Communication;Communities;community involvement;Complications of Diabetes Mellitus;Computer Hardware;Computer software;Data;design;E-learning;Educational workshop;Environment;experience;Feedback;Fostering;Funding;General Population;Goals;informatics infrastructure;Infrastructure;innovation;interest;Laboratories;Maintenance;meetings;member;Metabolic;metabolic phenotype;Modeling;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Occupational activity of managing finances;operation;Pilot Projects;Process;programs;Records;Reporting;Research;Research Personnel;Resources;Science;Services;software systems;Software Tools;success;symposium;System;Teleconferences;Training;Travel;Visualization software;web portal;web site;web-based tool

PROJECT_TITLE: Coordinating Unit for the Innovative Science Accelerator Program


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;HIV/AIDS;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_NAME: NORTHERN CALIFORNIA INSTITUTE/RES/EDU

ORG_STATE: CA

PHR: A major goal in HIV infection and for the NIH is to improve diagnosis of ongoing cognitive impairment as well as monitor brain health with the advent of new therapies and cure tactics. This proposal demonstrates that extracellular vesicles shed from neurons into the peripheral blood have newly discovered proteins that correlate with cognitive impairment and differ in men versus women. We will correlate these biomarkers with neuroimaging and develop a panel of proteins for prognosis and diagnosis of neurocognitive impairment.

PI_NAMEs: PULLIAM, LYNN  (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;Aftercare;Age;Aging;aging population;Alzheimer's Disease;Amyloid beta-Protein;Antibodies;Antigens;Basic Science;Biological Assay;Biological Markers;biomarker selection;Brain;brain health;Cell surface;Cells;Chronic;clinical diagnosis;Cognition;Cognitive;cohort;Cohort Studies;Communicable Diseases;Diagnosis;differential expression;Discipline;exosome;extracellular vesicles;Funding;Goals;Hand;Health;HIV;HIV diagnosis;HIV Infections;HIV Seronegativity;HIV-associated cognitive impairment;HIV-associated neurocognitive disorder;HMGB1 gene;Image;Impaired cognition;Impairment;improved;Incubated;Individual;Injury;interdisciplinary approach;interest;Label;Light;Liquid substance;Longitudinal cohort;Mass Spectrum Analysis;men;microvesicles;mild cognitive impairment;Monitor;neural;Neural Cell Adhesion Molecule L1;Neurocognitive Deficit;neurocognitive disorder;neurofilament;neuroimaging;neuroimaging marker;neuroinflammation;Neurology;Neurons;Neurosciences Research;novel therapeutics;Oligonucleotides;Parents;Pathogenesis;Pathologic;peripheral blood;Persons;Plasma;Probability;Procedures;Prognosis;protein biomarkers;Proteins;Radiology Specialty;Recovery;Techniques;Technology;Testing;Time;United States National Institutes of Health;Virus Replication;Woman;women versus men;Women's Interagency HIV Study;women's treatment

PROJECT_TITLE: Plasma neuronal-derived exosomes are biomarkers of HIV cognitive impairment

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: MILWAUKEE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE Alzheimer's disease (AD) is the most common form of dementia globally, but current therapies only treat its symptoms but cannot stop disease progression. Using genetic tools combined with high-resolution synaptic imaging to manipulate and monitor the central hallmark of AD—degenerative synapse loss, we will investigate its molecule and cellular mechanisms in the AD brain. The proposed studies will examine a new paradigm essential to axonal and synaptic degeneration and potentially identify novel strategies that may ultimately transform current therapies to protect synaptic connection and cognitive function in AD patients.

PI_NAMEs: LOU, XUELIN  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: abeta accumulation;Abeta synthesis;Acceleration;Alzheimer associated neurodegeneration;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease diagnosis;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;Amyloid beta-Protein;Animals;Axon;axonal degeneration;Behavior;Behavioral;beta amyloid pathology;Biochemical;Biochemistry;Biological Assay;Biology;Brain;Clinical Trials;Cognitive;cognitive function;cognitive performance;Data;Degenerative Disorder;Dementia;Development;Disease;Disease Progression;Electrophysiology (science);experimental study;Failure;Feedback;Genetic;Grant;high resolution imaging;Hydrolase;Image;Imaging Device;Impaired cognition;improved;in vivo;insight;interest;Interleukin-1 Receptors;Intervention;Knock-out;knockout gene;Knowledge;Learning;Light;loss of function;Mediating;Memory;Memory Loss;Metabolism;Molecular;Monitor;mouse genetics;mouse model;Mus;Nerve;Nerve Degeneration;neural circuit;Neuroimmune;neuroinflammation;Neurologic;Neurologic Deficit;neuron loss;neuronal cell body;Neurons;new therapeutic target;novel;novel strategies;Onset of illness;Outcome;Pathogenesis;Pathologic;Pathway interactions;Play;Presynaptic Terminals;Process;Proteins;Recycling;Research;Research Personnel;Resolution;Retrieval;Role;Scheme;Senile Plaques;Signal Pathway;Signal Transduction;Specific qualifier value;Sterility;Stress;superresolution imaging;Symptoms;Synapses;Testing;tool;translational approach;Vesicle;Work

PROJECT_TITLE: Understanding the degeneration of axon and nerve terminals in Alzheimer's disease and related dementia brain

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


NIH_SPENDING_CATS: Diabetes;Genetics;Nutrition;Obesity

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: Project Narrative: Type 2 Diabetes (T2D) and several life-threating complications of T2D share, as a major cause, insulin resistance for which the etiology is not fully understood, thus limiting the ability to develop highly effective and safe insulin- sensitizing medications. Palmitic Acid Hydroxy Stearic Acids (PAHSAs), endogenous lipids with potent insulin- sensitizing effects in obese T2D mice, are highly associated with insulin-sensitivity in humans and markedly down-regulated in the adipose tissue and serum of insulin resistant individuals. Combining cutting-edge, unbiased and synergetic approaches, we will determine the mechanisms responsible for the down-regulation of PAHSAs in insulin-resistant individuals and identify the enzymatic program responsible for the synthesis and degradation of PAHSAs in mammalian cells, providing novel therapeutic avenues to prevent or treat insulin resistance and T2D.

PI_NAMEs: SANTORO, ANNA  (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Academia;Address;Adipocytes;Adipose tissue;Advisory Committees;Anabolism;Anti-diabetic Drugs;Anti-Inflammatory Agents;Binding Proteins;Bioinformatics;Biological Assay;Biopsy;blood glucose regulation;candidate identification;Carbohydrates;career;career development;Computer Models;CRISPR/Cas technology;Data;Data Set;Development;Development Plans;Diabetes Mellitus;Down-Regulation;Economic Burden;Endocrine;Environment;enzyme biosynthesis;Enzymes;Esters;Etiology;Experimental Designs;Fasting;feeding;Funding;Future;Genes;Genetic;Genetic Models;Genetic Variation;Genomic Segment;glucose tolerance;Glucose Transporter;GLUT 4 protein;Goals;Grant;Hepatic;High Fat Diet;Human;Hydrolysis;Hydroxy Acids;improved;in vivo;Individual;Infusion procedures;innovation;insight;Insulin;Insulin Resistance;insulin sensitivity;insulin sensitizing drugs;interest;Isotopes;knockout gene;Knockout Mice;Label;Life;lipid biosynthesis;lipid metabolism;lipidomics;Lipids;Mammalian Cell;Maps;Measures;Mediating;Mediation;meetings;Mentored Research Scientist Development Award;Mentorship;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolism;metabolomics;Methods;Molecular;Molecular Biology;mouse model;Mouse Strains;multiple omics;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;novel therapeutics;Obese Mice;Obesity;overexpression;Palmitic Acids;Pathway interactions;Periodicals;Persons;Pharmaceutical Preparations;Phenotype;Physiological;Population;post-doctoral training;Preparation;prevent;Process;programs;Protocols documentation;Quantitative Trait Loci;Regulation;Research;Research Personnel;Response Elements;Role;Scientist;Serum;Site;skills;social;Stearic Acids;Technology;Testing;Therapeutic;Tissues;Training;trait;transcriptome sequencing;translational study;Triglycerides;United States National Institutes of Health;Variant

PROJECT_TITLE: Mechanisms for the regulation of novel lipids in vivo

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: LA JOLLA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: The proposed research is relevant to public health because it represents a novel approach to understanding the relationship between the gut microbiome, bile acid signaling, and fertility. I will determine whether microbial bile acid biotransformations affect host reproduction and the HPG axis. The proposed research will work to find new therapeutic targets that will improve reproductive health and reduce infertility.

PI_NAMEs: MAISSY, ERICA  (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: absorption;Address;Affect;Androgen Receptor;Androgens;Animal Disease Models;Back;Bacteria;Bile Acids;Bile fluid;career development;career networking;Circulation;cohort;Data;design;Development Plans;Embryonic Development;Engineering;Engraftment;Environment;Escherichia coli;experimental study;Female;Fertility;fitness;Frequencies;Goals;Gonadal Steroid Hormones;Gonadal structure;gut microbes;gut microbiome;Homeostasis;host-microbe interactions;hypothalamic pituitary gonadal axis;Hypothalamic structure;improved;In Vitro;Infertility;Inflammation;innovation;insight;interest;Knock-in;Learning Skill;male;Measures;Mediating;meetings;Mentors;Mentorship;Metabolic Biotransformation;Metabolism;Methods;microbial;microbiome;microbiome research;microorganism;Modification;Mus;Nature;new therapeutic target;novel;novel strategies;Nuclear;Nuclear Receptors;Outcome Study;Pathway interactions;Physiological;Physiology;Public Health;pup;receptor;Receptor Signaling;Reproduction;reproductive;reproductive axis;reproductive function;Reproductive Health;Reproductive Physiology;Research;research and development;Research Personnel;Role;Sample Size;Scientist;secondary metabolite;Serum;sexual dimorphism;Signal Transduction;Signaling Molecule;skills;Source;subfertility;Supplementation;System;Testing;Testis;Testosterone;therapeutic target;Time;Tissues;tool;Training;translational impact;vector;Weaning;Wild Type Mouse;Work

PROJECT_TITLE: The Impact of Gut Bile Acid Deconjugation on Host Fertility

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-V(20)L]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Fragile X Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Using EEG to better understand the neural mechanisms of language acquisition in the context of neurodevelopmental disorders such as Fragile X Syndrome (FXS) and autism spectrum disorder (ASD) is crucial to the development of targeted drug and behavioral-based interventions to improve developmental outcomes in these children. EEG-markers identified during this study could be used as an objective measure of language prognosis, treatment monitoring during clinical trials, and ultimately development of effective therapeutics. In addition, improved understanding of the similarities and differences between FXS and ASD can help generalize these findings to the broader ASD community.

PI_NAMEs: WILKINSON, CAROL LEE (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: 2 year old;5 year old;Adult;Affect;Age;aged;Animal Model;Area;Auditory;Auditory Evoked Potentials;auditory processing;autism community;autism spectrum disorder;autistic children;Behavioral;biomarker identification;Boston;boys;Brain;brain behavior;Child;Child Development;Clinical Trials;Cognitive;cognitive ability;Cognitive deficits;cognitive neuroscience;cognitive skill;cognitive testing;Cohort Studies;Communication;cost;Data;design;Detection;Development;Developmental Course;Diagnosis;Disease;Drug Targeting;Dyslexia;Electroencephalography;Electrophysiology (science);endophenotype;Environment;Epidemiology;experience;Fragile X Syndrome;Frequencies;Funding;Future;Genes;Genetic Models;Goals;high risk;Impairment;improved;Individual;Intellectual functioning disability;Intervention;K-Series Research Career Programs;Language;Language Delays;Language Development;Language Disorders;language impairment;Learning;Lifelong disability;Measures;Mentors;minimally verbal;model of autism spectrum disorder;Molecular;Monitor;mouse model;National Institute on Deafness and Other Communication Disorders;Natural History;neural;neural network;Neural Pathways;Neurobiology;Neurodevelopmental Disorder;neuroimaging;neuromechanism;non-verbal;Nursery Schools;Outcome;Participant;participant enrollment;Pathway interactions;Pattern;Pediatric Hospitals;Phenotype;Physicians;Play;Population;Populations at Risk;predictive marker;Production;Prognosis;prognosis biomarker;programs;Research;Research Design;Research Personnel;Resources;response;Rest;Risk;Role;School-Age Population;Scientist;social;Speech;Strategic Planning;Synaptic plasticity;Techniques;therapeutically effective;Training;Universities;Visit;Voice

PROJECT_TITLE: Neural Markers of Language Development in Fragile X Syndrome and Autism Spectrum Disorder


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences;Pediatric

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE There are a large number of motor dysfunctions in neonates that could arise by anomalous development of spinal cord microcircuits. A major deficit is our little knowledge about the organization of spinal cord microcircuits controlling motoneuron activity and how they develop and mature in newborns. We propose to study one subclass of genetically defined interneurons that we hypothesize plays major roles in coordinating muscles activities during motor behaviors. We will investigate their development and their role in maturing coordinated motor function.

PI_NAMEs: ALVAREZ, FRANCISCO J (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Adult;Affect;Anatomy;Animal Model;Ankle;Automobile Driving;Brain;Cells;Cerebral Palsy;Chest;Chronic;combinatorial;Compensation;connectome;Data;Derivation procedure;Development;Disinhibition;Dissection;Explosion;Extensor;Feedback;Flexor;forkhead protein;Genes;Genetic;genetic approach;Goals;Grant;Health;Heterogeneity;Hip region structure;Human;Interneurons;Ipsilateral;juvenile animal;kinematics;Knee;Knowledge;Label;Link;Location;Locomotion;Mediating;Modeling;Motor;motor behavior;motor control;motor deficit;motor disorder;Motor Neurons;Motor output;Movement;Mus;Muscle;Muscle Contraction;Myelin P2 Protein;Neonatal;neonate;Neurons;Newborn Infant;novel;Organizational Productivity;Pathway interactions;Pattern;Periodicity;Phase;Play;Positioning Attribute;postnatal;postnatal development;progenitor;Property;Proteins;recruit;Recurrence;Renshaw Cell;Reporting;Role;Shapes;Source;Speed;Spinal;Spinal Cord;Spinal cord injury;Spinal Muscular Atrophy;stretch reflex;Subgroup;Synapses;Syndrome;Testing;transcription factor;treadmill;Viral;Work

PROJECT_TITLE: Development of Synaptic Inputs on Spinal Interneurons

STUDY_SECTION: SMI

STUDY_SECTION_NAME: Sensorimotor Integration Study Section[SMI]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS

PHR: PROJECT NARRATIVE The human immunodeficiency virus (HIV-1) envelope glycoproteins (Env) change shape to allow the virus to enter host cells and to evade host antibodies. Before HIV-1 encounters its receptors on the host cell, Env is in a pretriggered shape that is a key target for effective virus entry inhibitors and virus-neutralizing antibodies. Understanding this pretriggered Env shape, and how it is maintained despite HIV-1's variability, will assist efforts to design treatments and vaccines.

PI_NAMEs: SODROSKI, JOSEPH G (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Adopted;Amino Acids;Antibodies;Antibody Response;Binding;Biological;CCR5 gene;CD4 Positive T Lymphocytes;Cell membrane;Cell surface;Cells;Compensation;Complement;conformational conversion;crosslink;CXCR4 gene;Cytoplasmic Tail;design;Detergents;Disease;Elements;Environment;Exhibits;Exposure to;flexibility;Funding;Genetic Polymorphism;glycoprotein structure;Glycoproteins;glycosylation;Goals;Grant;HIV;HIV envelope protein;HIV Envelope Protein gp120;Immune Evasion;Immune system;immunogenicity;inhibitor;interest;Maintenance;Mass Spectrum Analysis;Mediating;Membrane;Membrane Fusion;Molecular Conformation;Molecular Machines;mutant;Nature;neutralizing antibody;novel;Phenotype;Predisposition;Process;Property;prototype;receptor;Regulation;Research;Resistance;Rest;restraint;Sampling;Shapes;small molecule;small molecule inhibitor;Structure;Surface;Testing;therapy design;Thermodynamics;Tropism;Vaccination;Vaccines;Viral;Virion;Virus;Virus Diseases;virus envelope;Work

PROJECT_TITLE: Conformational Landscape of the HIV-1 Envelope Glycoproteins

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Fragile X Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: There are no approved treatments for congenital cognitive impairments in individuals with Autism Spectrum Disorder (ASD). However, our preliminary results indicate that limited postnatal treatment with the hypothalamic peptide oxytocin can effect a life-long rescue of memory functions in the mouse model of Fragile- X Syndrome, the leading inherited cause of ASD. The proposed studies will test if postnatal oxytocin treatment rescues a range of social and episodic memory functions, and normalizes neurobiological processes underlying memory encoding in the Fragile X model mutants, and if these functional changes reflect direct oxytocin action on trophic signaling in the developing hippocampus.

PI_NAMEs: GALL, CHRISTINE M (contact);LYNCH, GARY S

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Acute;Address;Adult;Affect;Agonist;Animal Model;ASD patient;autism spectrum disorder;Behavior;Behavioral;Brain;Brain region;Brain-Derived Neurotrophic Factor;cellular targeting;Child;Childhood;Cognitive;cognitive function;comorbidity;critical developmental period;critical period;design;Development;developmental disease;Disease;DTR gene;early phase clinical trial;Electrophysiology (science);Elements;Epidermal Growth Factor Receptor;Episodic memory;Excitatory Synapse;Exhibits;Female;Fragile X Syndrome;Future;Genetic Techniques;Goals;Hippocampus;Hypothalamic structure;Impaired cognition;improved;individuals with autism spectrum disorder;Inherited;Inhibitory Synapse;Intellectual functioning disability;interest;Knowledge;Learning;Life;Location;Long-Term Potentiation;male;Measures;Mediating;Memory;memory encoding;Memory impairment;model of autism spectrum disorder;Modeling;Morphology;mouse model;Mus;mutant;Neurobiology;Neurodevelopmental Disorder;Neurons;Neuropeptides;Neurotrophic Tyrosine Kinase Receptor Type 2;novel;Odors;Oxytocin;Oxytocin Receptor;Peptides;personal narratives;Phenotype;Physiological;postnatal;postnatal period;Process;Property;Proteins;Receptor Protein-Tyrosine Kinases;Regimen;Regulation;response;restoration;Rodent Model;Role;Route;sex;Signal Transduction;social;Social Behavior;Social Interaction;Stereotyped Behavior;Structure;Synapses;synaptic function;Synaptic plasticity;Synaptic Receptors;System;Techniques;Testing;Therapeutic;therapeutic candidate;therapeutically effective;Thinking;Trophic Factor Receptor;Vertebral column;Wild Type Mouse;Work

PROJECT_TITLE: Postnatal Oxytocin Treatment and Cognitive Function in Fragile X

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Infectious Diseases;Neurosciences

PHR: Project Narrative This proposal aims to understand how microbial metabolites can influence the behavior of animal hosts, using the simple animal host Caenorhabditis elegans. We will conduct molecular genetic analysis of how the detection of microbial molecules alters neuroendocrine signaling and behavioral responses of C. elegans, with the anticipation that our studies will reveal mechanisms by which host-microbe interactions can influence diverse aspects of host physiology and behavior.

PI_NAMEs: KIM, DENNIS H (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Afferent Neurons;Animal Behavior;Animals;Attention;avoidance behavior;Bacteria;Behavior;behavior influence;behavioral response;Caenorhabditis elegans;Chemicals;Complex;Cues;Decision Making;Detection;Disease;Environment;Gene Expression;Genetic;genetic analysis;genetic approach;Goals;Homeostasis;host-microbe interactions;Immunity;Infection;insight;Ligands;Microbe;microbial;microbiota;Molecular;Molecular Genetics;National Institute of General Medical Sciences;Natural Immunity;Nervous System;Neurons;Neurosecretory Systems;neurotransmission;Organism;Pathogenesis;pathogenic bacteria;Pathway interactions;Physiology;programs;Pseudomonas aeruginosa;Regulation;Research;response;secondary metabolite;Sensory;Signal Transduction;Stress;Transforming Growth Factor beta;Virulence;Work

PROJECT_TITLE: Microbial Modulation of Physiology and Behavior of C. elegans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ORG_CITY: GAINESVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Our research focuses on elucidating how adult neurons control mitochondrial localization under aging and nerve injury conditions. Accurate regulation of mitochondrial localization is essential for maintaining neuronal function in response to age and injury. An improved understanding of the signaling mechanisms underlying the regulation of mitochondrial localization will suggest therapeutic strategies to improve axon regeneration of injured neurons and treat neurological diseases associated with mitochondrial abnormalities.

PI_NAMEs: HAN, SUNG MIN  (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: activating transcription factor 1;Acute;Address;Adult;Affect;Age;age related changes;age related decline;aged;Aging;Alzheimer's Disease;Alzheimer's disease model;Anabolism;Animals;Axon;axon injury;axon regeneration;Axotomy;Biology;Caenorhabditis elegans;Cell Nucleus;Cells;Communication;Data;Defect;Development;Distal;experimental study;Failure;Genetic;Genetic Models;Goals;Homeostasis;Homologous Gene;Imaging Techniques;improved;in vivo;in vivo imaging;Injury;innovation;insight;juvenile animal;Knowledge;Lasers;Maintenance;MAPK1 gene;Mediating;Mediator;Mitochondria;Molecular;Monitor;Motility;Movement;mutant;Mutation;Natural regeneration;nerve damage;Nerve Degeneration;nerve injury;Nervous System Disorder;Nervous System Physiology;Neuronal Injury;Neurons;novel;novel therapeutic intervention;Nuclear;Outcome;Oxidation-Reduction;Pathway interactions;Physiological;progressive neurodegeneration;Property;Quality Control;Recovery;Regenerative capacity;Regulation;Research;response;response to injury;Role;Signal Pathway;Signal Transduction;Site;Stimulus;Structure;Synapses;Testing;Therapeutic;therapeutic development

PROJECT_TITLE: The role and regulation of mitochondrial localization in mature neurons.

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Neurosciences

ORG_CITY: Chicago

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: PROJECT NARRATIVE The frequency-following response (FFR), a scalp-recorded neurophonic potential, is a widely-used metric of speech encoding integrity in healthy and clinical human populations. The translational potential of the FFR as a biomarker is constrained by poor understanding of its neural generators. This proposal leverages a cross-species and cross-level approach to provide mechanistic insight into the properties of the cortical source of the FFR, and elucidate the role of cortical feedback via cortico-collicular projections on modulation of the FFR as a function of stimulus context, arousal state, and category relevance.

PI_NAMEs: ABEL, TAYLOR JOHN;CHANDRASEKARAN, BHARATH  (contact);SADAGOPAN, SRIVATSUN ;TEICHERT, TOBIAS

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acceleration;Adult;Animal Model;Arousal;Attenuated;Audiology;Auditory area;Auditory Brainstem Responses;auditory pathway;auditory processing;Automobile Driving;Behavioral;Biological Markers;Categories;Cavia;cell type;Cells;Clinic;Clinical;clinical translation;Code;Complex;Computer Models;Consensus;Data;Dependence;Electrophysiology (science);Excision;expectation;experience;Experimental Genetics;falls;Feedback;Frequencies;Funding;Generations;genetic approach;Goals;Human;human model;insight;Language;Left;Lesion;Macaca;Measures;Modeling;Monitor;multimodality;neural;Neurobiology;Neurons;novel;optogenetics;Patients;Pattern;Phase;Population;pre-clinical;predictive modeling;Preparation;Process;Property;Protocols documentation;response;Response to stimulus physiology;Role;Scalp structure;sound;Source;Species Specificity;Speech;speech processing;Stimulus;System;Techniques;Testing;Time;translational potential;virtual;vocalization

PROJECT_TITLE: Cortical contributions to frequency-following response generation and modulation


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Longitudinal studies of structural racism and resulting inequalities in risk factors for Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD) are rare, especially in young adulthood. Additionally, effective population-level policies and interventions targeting structural racism to reduce racial inequalities in biological risk factors for AD/ADRD are sparse. The proposed study will create a database of multilevel, repeated, and prospective measures of structural racism; investigate the extent to which structural racism in education, residential, and criminal justice contexts shape Black-White inequalities in AD/ADRD risk; and use causal modeling techniques to evaluate the impact of structural interventions on documented racial inequalities in biological risk factors for AD/ADRD.

PI_NAMEs: HARGROVE, TAYLOR ;MARTIN, CHANTEL L. (contact)

PROGRAM_OFFICER_NAME: KARRAKER, AMELIA WILKES

PROJECT_TERMS: 10 year old;Address;Adolescence;Adolescent;Adult;Age;aging related;aging related disease;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;American;Area;Biological;Biological Aging;Biological Markers;Black American;Black race;black/white disparity;C-reactive protein;cardiovascular health;causal model;Censuses;Chronology;cohort;Communities;cost;County;Criminal Justice;Data;data repository;Data Set;Databases;Dementia;dementia risk;Development;Diabetes Mellitus;Diagnosis;Discrimination;Early Intervention;early onset;Economics;Education;education pathway;Educational Status;Effectiveness;epigenetic aging;Epigenetic Process;Ethnic Population;Expenditure;experience;experimental study;Exposure to;Geography;Goals;Growth;Health;health inequalities;Hypertension;Incidence;Individual;Inequality;Inflammation;insight;Institution;Interleukins;Intervention;Investigation;Knowledge;Life;Life Cycle Stages;Light;Link;Location;Longitudinal Studies;Measures;middle age;Modeling;models and simulation;Motion;multiple data sources;National Longitudinal Survey of Adolescent to Adult Health;Nature;neurofilament;Neurology;novel;novel marker;Onset of illness;Outcome;Pathway interactions;Physiological;Policies;Politics;Population;population based;prospective;Public Health;public health intervention;Public Policy;Race;racial disparity;racial population;racism;rate of aging;Research;residential segregation;Respondent;Risk;Risk Factors;school district;school environment;Schools;Shapes;Skin;social;stressor;Stroke;structural determinants;Structural Racism;tau Proteins;Techniques;theories;Time;United States;Work;young adult

PROJECT_TITLE: Multilevel Forms of Structural Racism and Racial Inequalities in ADRD Risk


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: DURHAM

ORG_NAME: PULVINAR NEURO LLC

PHR: PROJECT NARRATIVE – Pulvinar Neuro LLC, TOWNSEND Transcranial current stimulation (TCS) is a non-invasive form of brain stimulation that is being studied as a treatment for several psychiatric disorders, including depression and schizophrenia. This proposal develops XCSITE 300, a cloud-enabled TCS device that delivers individualized closed-loop stimulation and can be used in large double-blind placebo-controlled studies either in a clinic or research laboratory (XCSITE 300 Clinic) or at-home (XCSITE 300 Home). This work is of impact in human health because it is a key step towards novel brain stimulation treatments for mental illness, including depression.

PI_NAMEs: TOWNSEND, LEAH BISHOP (contact)

PROGRAM_OFFICER_NAME: GRABB, MARGARET CHRISTINE

PROJECT_TERMS: Acceleration;Address;Behavior;Brain;Cephalic;Clinic;Clinical;clinical care;clinical efficacy;Clinical Management;Clinical Trials;cloud based;Cloud Computing;cloud platform;Cognition;commercialization;Computer software;Controlled Clinical Trials;Data;design;Development;Devices;Double-Blind Method;Double-blind trial;effective therapy;electric field;Electroencephalography;feasibility testing;Feedback;first-in-human;flexibility;Future;Goals;Grant;Health;Home;Human;Individual;Infrastructure;innovation;Investigation;Laboratory Research;Left;Legal patent;Major Depressive Disorder;Market Research;Marketing;Measures;Mental Depression;Mental disorders;Monitor;Multi-Institutional Clinical Trial;neuronal circuitry;neurotechnology;next generation;noninvasive brain stimulation;novel;Outcome;Participant;Pathologic;Patient Self-Report;Patients;Pattern;Performance;performance tests;Periodicity;Persons;Phase;Pilot Projects;placebo controlled study;pressure;primary outcome;programs;prototype;psychiatric symptom;Psychiatry;Pulvinar structure;Randomized;recruit;remote grading;Remote management;Research;research clinical testing;response;Role;Schizophrenia;secondary outcome;Site;Small Business Innovation Research Grant;Symptoms;System;Technology;Testing;Time;tool;Translational Research;United States National Institutes of Health;Work

PROJECT_TITLE: XCSITE 300: Cloud-Enabled Closed-Loop Transcranial Current Stimulation Device for At-Home Studies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-C(10)B]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE This project examines a form of gene regulation by a molecular machine called condensin, which functions both in mitotic chromosome condensation and in interphase genome organization. Condensin is conserved from yeast to humans and mutations in condensin subunits have been linked to diseases such as microcephaly and cancer. An understanding of condensin’s role in gene regulation and development may lead to better treatments for these conditions.

PI_NAMEs: CSANKOVSZKI, GYORGYI  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Affect;Binding;Bioinformatics;Biological Process;Caenorhabditis elegans;cell type;Chromatin Fiber;Chromatin Loop;Chromatin Structure;Chromosome Condensation;Chromosome Segregation;Chromosome Structures;Chromosomes;Complex;condensin;Development;Disease;Dosage Compensation (Genetics);Gene Expression;Gene Expression Regulation;gene repression;Genes;Genome;Genomics;Germ Lines;Goals;Health;Hermaphroditism;histone modification;Histones;Human;Interphase;Lead;Link;Malignant Neoplasms;Mediating;Methods;Microcephaly;Microscopy;Mitosis;Mitotic;Mitotic Chromosome;Molecular Machines;Mutation;Nuclear;Organism;Patients;Phosphorylation;pluripotency;Post-Translational Protein Processing;precise genome editing;Process;programs;Proteins;Regulation;Reporting;Research;Role;sex;Sex Chromosomes;Techniques;Tissues;X Chromosome;Yeasts

PROJECT_TITLE: The gene regulatory functions of condensin

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Caregiving Research;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: EUGENE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: 8. Project Narrative The proposed research has public health implications because it will provide a multidimensional description of the lexical-semantic deficits seen in Latino Spanish-learning toddlers with early language delays and the supportive role of caregiver language input and interactions. This project is of particular relevance to NIH and NIDCD in that it aims to examine health disparities in dual-language learners with language impairments. The integration of a multidimensional approach and rich behavioral assessment in an understudied population will lead to better identification of, and intervention with, children with persistent language delays.

PI_NAMEs: DE ANDA, STEPHANIE  (contact)

PROJECT_TERMS: Academic achievement;Area;base;Behavior assessment;Behavioral;bilingualism;career;Caregivers;caregiving;Censuses;Child;Clinical assessments;design;Development;Dimensions;dynamic system;Early identification;Environment;experience;Future;Goals;Growth;health disparity;innovation;Intervention;Language;Language Delays;Language Development;language impairment;language outcome;Latino;Latino Population;Learning;lexical;Longitudinal Studies;Measures;meetings;Mental Health;Mentorship;Modeling;National Institute on Deafness and Other Communication Disorders;Nature;novel;Nursery Schools;Occupations;Oral;Outcome;Outcome Study;patient oriented;patient oriented research;Population;Population Intervention;Practice Guidelines;Production;Public Health;reading difficulties;Research;Research Personnel;Risk;Risk Marker;Role;Schools;Semantics;social skills;Spanish;Spanish/English;Systems Theory;theories;Time;Toddler;Training;United States;United States National Institutes of Health;Vocabulary;word learning;Work;young adult

PROJECT_TITLE: Building a Vocabulary: Lexical-semantic Development in Latino Children with Early Language Delay

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: TALLAHASSEE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: FLORIDA STATE UNIVERSITY

PHR: Project Narrative The goal of this project is to understand the communication and coordination of the moving parts within a molecular “recycling center” called the proteasome. The proteasome is an emerging drug target for numerous human diseases, including some cancers, several neurodegenerative disorders, and a number of infectious diseases. Understanding this communication will help us to design new treatments for these diseases that work by controlling protein recycling inside cells.

PI_NAMEs: TOMKO, ROBERT JOSEPH (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: 26S proteasome;Animals;anti-cancer;Architecture;Area;ATP phosphohydrolase;Autoimmune Diseases;Autophagocytosis;base;Binding;Biogenesis;Biological Assay;Biology;Budgets;Catalysis;Cells;combat;Communicable Diseases;Communication;Complement;Complex;conformational conversion;Conserved Sequence;Coupled;Cytoprotection;Dedications;design;Diabetes Mellitus;Disease;Dissociation;Distant;drug discovery;Drug Targeting;effective therapy;Elements;Equilibrium;Eukaryota;Event;Excision;Family;flexibility;Fluorescence Resonance Energy Transfer;Goals;guided inquiry;Health;Hot Spot;Human;human disease;human pathogen;in vivo;Infection;inhibitor;insight;interest;Kinetics;Knowledge;Ligand Binding;Ligands;Link;Malignant Neoplasms;Mediating;Microsporidia;Modeling;Molecular;Molecular Chaperones;Molecular Conformation;Movement;multicatalytic endopeptidase complex;Mutation;Nerve Degeneration;Neurodegenerative Disorders;novel;novel therapeutics;Nucleosome Core Particle;Parasites;Parasitic infection;Pharmaceutical Preparations;priority pathogen;Process;protein degradation;Proteins;Proteolysis;Quality Control;Reagent;Recycling;Role;Route;Signal Transduction;Site;Structure;Testing;tool;transmission process;Tyrosine;United States National Institutes of Health;Work;Yeasts

PROJECT_TITLE: Engagement and Communication Between Proteasomal Subcomplexes

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Aging causes arterial stiffness, which is a hallmark of cardiovascular diseases and related to vascular dementias. This project probes the role of neutrophil elastase, a neutrophil-specific protease, in age-related vascular damage and stiffness in mice. This study may shed new light on a novel therapeutic strategy to alleviate the development of aging-related cardiovascular diseases and vascular dementias.

PI_NAMEs: JIANG, ZHEN YUE (contact)

PROGRAM_OFFICER_NAME: STABLEY, JOHN N

PROJECT_TERMS: Acetylation;age related;aged;Aging;aging process;aging related;Amiloride;Animals;Aorta;arterial stiffness;B-Lymphocytes;Blood Pressure;Blood Vessels;BMP2 gene;C57BL/6 Mouse;calcification;Cardiovascular Diseases;Cell Adhesion Molecules;Cells;chemokine receptor;Chronic;connective tissue growth factor;CXC Chemokines;Cytoplasmic Granules;Data;Deacetylase;Development;Diet;Disease;DNA Binding;Elastases;Endothelium;epithelial Na+ channel;Event;Extracellular Matrix;Extravasation;Fatty acid glycerol esters;feeding;Female;Fibrosis;Fructose;Human;Immune;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;Injury;Knock-out;Knockout Mice;Leucocytic infiltrate;Leukocyte Elastase;Leukocytes;life span;Longevity;MADH2 gene;male;Measures;Medial;Mediating;Mediator;migration;Molecular;mouse model;Mus;neutrophil;neutrophil elastase inhibitor;Neutrophil Infiltration;novel;novel therapeutic intervention;Nuclear Translocation;Obesity;obesogenic;old mice;Oral;osteogenic;Oxidants;PAR-2 Receptor;Pathologic;Pathway interactions;Peptide Hydrolases;Permeability;Phenotype;Phosphotransferases;Physiologic pulse;Play;Prevalence;Production;progenitor;protective effect;Regulation;Reporting;Resistance;Role;Serine Protease;Signal Pathway;Signal Transduction;SIRT1 gene;Site;Smooth Muscle;Smooth Muscle Myocytes;Testing;Therapeutic Effect;tissue injury;Tissues;Transforming Growth Factor beta;Vascular Dementia;Vascular Endothelial Cell;Vascular Endothelium;vascular endothelium permeability;vascular injury;Vascular Permeabilities;Vascular remodeling;Vascular Smooth Muscle

PROJECT_TITLE: Neutrophils play a pivotal role in vascular aging

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: HAMPTON

ORG_NAME: HAMPTON UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative. There is an urgent need to expand the number of underrepresented minorities in STEM. Hampton University proposes the implementation of the U-RISE program which endeavors to: 1) increase the number of students interested in research careers; 2) improve STEM retention rates; 3) improve academic performance and achievement in training eligible departments; 4) increase the number of students from Hampton pursuing and matriculating in PhD or MD/PhD programs in biomedical sciences; and 5) implement effective mentoring and enhanced opportunities for pre-U-RISE and U-RISE Scholars through formal mentor training and engagement of U-RISE faculty in program activities. Overall, the proposed curriculum and activities will continue to enhance students’ skills and prepare scholars for entry into top-ranked biomedical PhD or MD/PhD programs. This program will also improve the mentoring capacity of faculty at Hampton University.

PI_NAMEs: EREBHOLO, FRANCIS ;NJOKI, PETER  (contact);WATKINS, JERMEL

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Achievement;Affect;Bachelor's Degree;Biomedical Research;career;CCL7 gene;Country;Degree Completion;design;Doctor of Philosophy;Educational Curriculum;Eligibility Determination;Faculty;Fostering;Funding;Goals;Historically Black Colleges and Universities;improved;innovation;Institution;interest;matriculation;Mentors;Performance;Preparation;programs;Qualifying;Research;retention rate;Science;skills;Students;Training;Underrepresented Minority;United States National Institutes of Health;Universities

PROJECT_TITLE: U-RISE at Hampton University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Relevance This project will evaluate the accuracy of noninvasive methods for estimating brain connectivity in humans and monkeys, compare areal organization across species, and characterize individual variability of cortical organization using a multimodal parcellation derived from the Human Connectome Project. Results will be shared via a state-of-the-art database that stores extensively analyzed data. These efforts will increase our understanding of normal human brain circuitry and organization and may ultimately contribute to better diagnosis and treatment of brain disorders.

PI_NAMEs: VAN ESSEN, DAVID C (contact)

PROGRAM_OFFICER_NAME: BENNETT, YVONNE MARIE

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Adult;advanced analytics;Algorithms;analytical tool;anatomical tracer;Anatomy;Anesthesia procedures;Area;Atlases;Brain;brain circuitry;Brain Diseases;Brain imaging;Brain Mapping;Callithrix;Cerebral cortex;Classification;Communities;Computer software;computerized;connectome;Data;Data Analyses;Data Set;Databases;denoising;design;Diagnosis;Electroencephalography;Electrophysiology (science);Evaluation;Evolution;Family;Functional Magnetic Resonance Imaging;functional MRI scan;Grant;Heritability;Hour;Human;improved;Individual;Individual Differences;individual variation;Injections;insight;Internet;interoperability;Link;Macaca;Machine Learning;Magnetic Resonance Imaging;Maps;Measures;Methods;Modeling;Monkeys;multimodal data;multimodality;Myelin;Neighborhoods;Neuroanatomy;neuroimaging;neurophysiology;nonhuman primate;novel;novel strategies;Outcome;Publishing;Recommendation;reconstruction;Reference Values;Reproducibility;Research Design;Rest;Sampling;Scanning;Site;Surface;Testing;Time;tool;Tracer;Twin Multiple Birth;user-friendly;Visualization;young adult

PROJECT_TITLE: Reconstructions and Representations of Cerebral Cortex

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Acute kidney injury (AKI) significantly increases the risk of developing chronic kidney disease (CKD). T cells and polymorphonuclear neutrophils (PMNs) play important roles during AKI-to-CKD transition. This proposal will seek to (1) identify the signals that home T cells and PMNs during AKI-to-CKD transition and (2) develop innovative translational nanoparticles that can selectively deliver siRNAs to knockdown these homing signals to slow or even prevent CKD progression.

PI_NAMEs: XU, LEYUAN  (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Adhesions;Atrophic;Attenuated;Bilateral;CCL8 gene;CCR1 gene;CD4 Positive T Lymphocytes;Cell Adhesion;Cell Surface Proteins;cell type;Cells;chemokine;chronic infection;Chronic Kidney Failure;Clinical;Contralateral;CXCR6 gene;Data;data repository;Data Set;Dendrimers;Development;Disease;disease model;Disease Progression;Exhibits;Failure;Fibrosis;folate-binding protein;Folic Acid;Functional disorder;Home;Homing;Immune;immune activation;Immune System Diseases;Immune Targeting;improved;In Vitro;in vivo;Inflammation;inflammatory milieu;injured;Injury;Injury to Kidney;innovation;interest;Ischemia;Kidney;kidney biopsy;Kidney Diseases;kidney fibrosis;kidney repair;knock-down;Knockout Mice;Lead;Macrophage;Mannose;mannose receptor;Mediating;Modeling;mouse model;Myofibroblast;nanoparticle;neutralizing antibody;neutrophil;Neutrophil Infiltration;Organ;Pathogenesis;Patients;Pharmaceutical Preparations;pharmacologic;Play;Population;pre-clinical;prevent;PTPRC gene;Publications;Publishing;receptor;Recovery;recruit;Renal Hypertension;repaired;Reperfusion Injury;Risk;Role;Secondary to;severe injury;Signal Transduction;single-cell RNA sequencing;siRNA delivery;Small Interfering RNA;Source;Stains;T cell infiltration;T-Cell Depletion;T-Lymphocyte;targeted delivery;targeted treatment;Testing;therapeutic target;Time;Transgenic Mice;Translating;Tubular formation;Vascular Cell Adhesion Molecule-1;Work

PROJECT_TITLE: Targeting immune dysfunction during transition from AKI to CKD

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Digestive Diseases;Eczema / Atopic Dermatitis;Emerging Infectious Diseases;Food Allergies;Infectious Diseases;Microbiome;Nutrition;Prevention

PHR: Project Narrative  The skin of the vast majority of patients with Atopic Dermatitis (AD) is colonized by Staphylococcus aureus bacteria that secrete toxins called superantigens, predominantly staphylococcal enterotoxin B. We propose to use a mouse model of AD to examine the mechanisms by which skin colonization by S. aureus and the SEB they secrete result in more severe food allergy in patients with AD. It is anticipated that the results obtained will lead to novel therapies for food allergy.

PI_NAMEs: GEHA, RAIF SALIM (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: absorption;Address;Affinity;Allergic;Allergic Reaction;Anaphylaxis;Antibodies;antigen challenge;Antigens;Atopic Dermatitis;Attenuated;Bacteria;Basophils;Binding;CASP8 gene;Caspase;Cells;Data;Dendritic Cells;Disease;draining lymph node;Epithelial Cells;Epithelium;Event;Exposure to;Food;food antigen;Food Hypersensitivity;IgE;IL3 Gene;In Vitro;in vivo;Inflammation;inhibitor;Interleukin-4;Intestinal Absorption;intestinal barrier;intestinal epithelium;Intestinal permeability;keratinocyte;mast cell;Mediating;Mediator;Monoclonal Antibodies;mouse model;Mus;Myosin Light Chain Kinase;novel therapeutics;Oral;Ovalbumin;passive sensitization;Pathway interactions;Patients;Predisposition;Proteins;receptor;recruit;response;Role;Scheme;Serum;Signal Transduction;Skin;Skin colonization;small molecule;Staphylococcal Enterotoxin B;Staphylococcus aureus;Stromal Cells;Superantigens;synergism;T-Lymphocyte;Technical Expertise;Testing;Tight Junctions;TNFRSF5 gene;Toxin

PROJECT_TITLE: Mechanisms of enhanced food allergy by S. aureus skin colonization in Atopic Dermatitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDB-K(57)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE: PRC2 is a context-dependent tumor suppressor whose core components (e.g., EZH2, EED, or SUZ12) are inactivated in various cancer types, and PRC2-loss in cancer leads to enhanced cellular plasticity, aberrant activation of multiple signaling pathways, an immune-desert tumor microenvironment and resistance to immune checkpoint blockade. In selected cancer types, we uncovered that PRC2-loss enhances cytotoxic responses to DNMT1 inhibition and anti-tumor responses to immunogenic viruses through activation of double-stranded RNA (dsRNA)-sensing and signaling responses. We propose innovative and integrative approaches to dissect the molecular mechanisms and evaluate novel therapeutic strategies (e.g., DNMT1 inhibitors, synthetic dsRNA, second generation of engineered immunogenic viruses) in relevant PRC2-loss cancer models to facilitate future design of biomarker driven clinical trials in PRC2-loss cancers with the goal to improve outcomes in individuals with MPNST and other PRC2-loss cancers.

PI_NAMEs: CHI, PING  (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: Alleles;antitumor effect;Antitumor Response;Autophagocytosis;Biochemical;biomarker driven;C57BL/6 Mouse;cancer cell;Cancer Model;cancer type;Cells;Chromatin Structure;Clinical Trials;Complex;cytotoxic;cytotoxicity;Data;Decitabine;demethylation;design;Development;DNA Modification Methylases;Double-Stranded RNA;effective therapy;Engineering;Engraftment;epigenome;Evaluation;Evolution;EZH2 gene;Future;Generations;Genetic;Genetic Transcription;Genome;Goals;High Prevalence;Histone H3;histone methylation;Immune;immune checkpoint blockade;Immune response;Immunocompetent;immunogenic;immunogenicity;Immunologic Cytotoxicity;Immunotherapy;improved outcome;In Vitro;in vivo;Individual;Infection;inhibitor;Innate Immune Response;innovation;insight;IRF3 gene;knock-down;Lysine;Malignant Neoplasms;Mammary Neoplasms;Mediating;Melanoma;Modeling;Molecular;mouse model;multiple omics;Mus;neoplastic cell;Neurofibrosarcoma;NF-kappa B;novel;novel therapeutic intervention;Outcome;Phenotype;Polycomb;pre-clinical;Recombinant modified vaccinia virus Ankara;Resistance;response;Retrotransposon;Role;sensor;Signal Pathway;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Soft tissue sarcoma;stemness;stress granule;System;Therapeutic;Transcriptional Activation;transcriptome;treatment effect;tumor;tumor growth;tumor heterogeneity;tumor microenvironment;Tumor Suppressor Proteins;Virus;Work

PROJECT_TITLE: Harnessing double stranded-RNA (dsRNA)-response and anti-tumor effect in PRC2-inactivated cancer


NIH_SPENDING_CATS: Aging;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Prevention;Rehabilitation;Sleep Research

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Both insomnia and Post Traumatic Stress Disorder (PTSD) are independent risk factors for cardiometabolic diseases; the leading causes of morbidity and mortality in the US for which the growing geriatric population is at elevated risk. PTSD and insomnia disorder frequently co-occur yet require unique treatments, thus the proposed project will evaluate the added benefits of treating residual insomnia symptoms with Cognitive- Behavioral Therapy for Insomnia (CBT-I) following Cognitive Processing Therapy (CPT) for PTSD among understudied older adults with PTSD. Findings from this pilot study will expand our understanding of the relationships between evidence-based insomnia and PTSD treatments and key outcomes of sleep, PTSD symptoms, cardiometabolic health and quality of life in older adults with PTSD and insomnia while informing future research.

PI_NAMEs: KELLY, MONICA R (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Address;Age;Aging;Arousal;Behavioral;behavioral sleep intervention;Biological Markers;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;career;career development;Cause of Death;Circadian Rhythms;clinical care;clinical center;Clinical Investigator;Clinical Psychology;Clinical Sciences;Clinical Trials;Clinical Trials Design;Cognitive;cognitive benefits;Cognitive Therapy;cohort;Comorbid Insomnia;Data;Diabetes Mellitus;Disease Management;Disease remission;disorder risk;Doctor of Philosophy;Dyslipidemias;Education;effective therapy;Elderly;Environment;evidence base;Evidence based intervention;experience;Failure;falls;fasting glucose;Fellowship;follow-up;Foundational Skills;Functional impairment;Funding;Geriatrics;Gerontology;Glycosylated hemoglobin A;Goals;Health;Healthcare Systems;Heart Diseases;high risk;Hyperglycemia;Hypertension;improved;improvement on sleep;Individual;individualized medicine;Insulin;Insulin Resistance;Intervention;Knowledge;late life;Licensure;Link;Lipids;Measures;Mediating;medical schools;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;military veteran;modifiable risk;mood symptom;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;Neurobehavioral Manifestations;Obesity;older adult;Older Population;Outcome;Participant;Patients;physical conditioning;Pilot Projects;Play;poor health outcome;poor sleep;Population;Post-Traumatic Stress Disorders;Professional Competence;professor;programs;Psychotherapy;Quality of life;Randomized;randomized trial;Randomized, Controlled Trials;Research;Research Methodology;Research Personnel;Residual state;Resources;Risk;Risk Factors;Role;Severities;skill acquisition;Sleep;Sleep Apnea Syndromes;Sleep disturbances;Sleeplessness;Stress;Stroke;Symptoms;theories;Training;Translational Research;Trauma;trauma exposure;trial design;United States National Institutes of Health;Veterans;Vietnam;Work;young adult

PROJECT_TITLE: Insomnia Treatment and Cardiometabolic Health in Older Adults with Posttraumatic Stress Disorder

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ORG_CITY: KIKUYU

ORG_COUNTRY: KENYA

ORG_FIPS: KE

ORG_NAME: BIOTECHNOLOGY RESEARCH INSTITUTE-KALRO

PHR: Narrative Tsetse flies transmit sleeping sickness and Nagana diseases that are fatal to humans to their livestock in sub- Sahara, with no effective vaccines. Tsetse control using odor baited traps and targets is considered an effective strategy for control of these diseases. Studies proposed here will investigate chemical ecology and behavioral responses of tsetse flies to odors, formulate novel tsetse attractants and repellents and optimize them for routine control of tsetse and trypanosomiasis in Kenya.

PI_NAMEs: MIREJI, PAUL O (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TITLE: Expanding the toolbox for tsetse control in Kenya

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


ORG_CITY: BOCA RATON

ORG_DEPT: BIOLOGY

ORG_NAME: FLORIDA ATLANTIC UNIVERSITY

PHR: Narrative The percentage of underrepresented minorities (URMs) graduating from bachelor programs far exceeds the URMs attaining PhDs in biomedical science. This disparity highlights the need to increase the diversity of URMs and other underrepresented groups in doctoral programs. This proposal seeks to implement an integrative curriculum that includes a specialized series of courses and workshops aimed at promoting critical thinking, while simultaneously immersing students in independent laboratory research.

PI_NAMEs: DUBOUE, ERIK ROLANDO (contact);FRAZIER, EVELYN ;MURPHEY, RODNEY K

PROJECT_TERMS: Biology;career;Communication;County;Critical Thinking;Doctor of Philosophy;Educational Curriculum;Educational workshop;Florida;Goals;graduate student;Institution;interest;Laboratory Research;matriculation;Mentors;Mentorship;Neurosciences;peer coaching;programs;Psychology;recruit;Research;Science;Services;Students;summer internship;support network;undergraduate research experience;Underrepresented Populations;Underrepresented Students;Universities

PROJECT_TITLE: U-RISE at Florida Atlantic University


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infant Mortality;Infectious Diseases;Malaria;Maternal Health;Microbiome;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases;Vector-Borne Diseases;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: NARRATIVE Malaria in pregnancy remains a major cause of adverse birth outcomes and neonatal mortality in Africa. Current strategies for the prevention of malaria in pregnancy are inadequate due to the emergence of resistance. The primary objective of this proposal will be to evaluate a novel combination of existing antimalarial drugs for prevention of malaria in pregnancy and improving birth outcomes.

PI_NAMEs: DORSEY, MATTHEW G (contact);ROSENTHAL, PHILIP JON

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: abortion;adverse birth outcomes;adverse event risk;Advisory Committees;Africa;Aftercare;Anemia;Anti-malarials;Antibiotics;Area;Artemisinins;Birth;Chemopreventive Agent;clinical infrastructure;Clinical Research;Combined Modality Therapy;Disease;Dose;Double-Blind Method;Drug usage;efficacy evaluation;fetal loss;Frequencies;gut microbiome;Half-Life;high risk;High Risk Woman;improved;Infant Mortality;Infection;Infection prevention;Insecticides;Low Birth Weight Infant;Malaria;malaria infection;Malaria prevention;malaria transmission;maternal risk;Measures;Neonatal Mortality;novel;Outcome;Parasite resistance;Parasitemia;Parasites;Pharmaceutical Preparations;placental malaria;Plasmodium falciparum;Policies;policy implication;Pregnancy;Pregnant Women;Premature Birth;Prevalence;prevent;Prevention;Prevention strategy;Preventive treatment;Prophylactic treatment;pyrethroid;Pyrimethamine;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;Regimen;Reproductive Tract Infections;Resistance;Risk;Risk Reduction;rural area;Safety;Small for Gestational Age Infant;Spontaneous abortion;standard care;standard of care;stillbirth;Sulfadoxine;symptom treatment;Testing;Treatment Efficacy;Uganda;vaginal microbiome;vector;Woman;World Health Organization

PROJECT_TITLE: Optimal chemopreventive regimens to prevent malaria and improve birth outcomes in Uganda


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: SEATTLE

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The major goal of this project is to gain better insights into blood flow changes that underlie grey matter loss during the secondary damage after cervical spinal cord injury. Limiting hemorrhage and surgical decompression are considered as strategies for improving grey matter damage and functional recovery.

PI_NAMEs: KHAING, ZIN Z (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: 3-Dimensional;3D ultrasound;Acute;Affect;Algorithms;Animals;Area;arm;arm function;Blood coagulation;Blood flow;Blood Vessels;Breathing;Cell Death;central gray matter;Cerebrovascular Circulation;Cervical;Cervical spinal cord injury;Cervical spinal cord structure;Cervical spine;Characteristics;Clinical Trials;contrast enhanced;Control Groups;Custom;Development;Doppler Ultrasound;Edema;Event;excitotoxicity;experience;Family suidae;feeding;Female;Frequencies;functional improvement;functional outcomes;Glyburide;Goals;gray matter;Grooming;Hand;Hand functions;Hematoma;hemodynamics;Hemorrhage;Histologic;Human;Image;Imaging Techniques;improved;in vivo;Individual;Inflammation;Injury;innovation;insight;Ischemia;Legal patent;Lesion;Life;Limb structure;Longitudinal Studies;Magnetic Resonance Imaging;male;mechanical pressure;Mechanics;meter;Microbubbles;Microcirculation;Modeling;Monitor;Morphology;Motor;nerve supply;neural;Neurologic;Neurological outcome;Neurons;new technology;novel;Operative Surgical Procedures;Paralysed;Patient-Focused Outcomes;Patients;Perfusion;Phase;Play;preservation;pressure;Process;Quadriplegia;Quality of life;Rattus;Recovery;Recovery of Function;Research;Resolution;Respiration Disorders;Respiratory Diaphragm;response;Risk;Rodent;Rodent Model;Role;Secondary to;Sensory;Sex Differences;Spinal;Spinal Cord;Spinal Cord Contusions;Spinal cord damage;Spinal cord injury;Sterile coverings;Surgical Decompression;Swelling;Techniques;temporal measurement;Testing;Therapeutic;Thoracic spinal cord structure;Three-Dimensional Image;Three-Dimensional Imaging;Time;Tissues;Transcutaneous Electric Nerve Stimulation;Trauma;treatment effect;treatment group;treatment strategy;Ultrasonography;ultrasound;Upper Extremity;Visualization;white matter;Work

PROJECT_TITLE: Hemodynamic basis for secondary cervical grey matter tissue loss after spinal cord injury

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Organ Transplantation;Transplantation

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Cardiac allograft vasculopathy is a pan-arterial disease that impacts 50% of patients within ten years of heart transplantation and is the cause of death for up to 1/3rd of patients. Currently our understanding of the mechanism of CAV and the standard modalities to diagnose CAV are insufficient. Achieving our aims will set the stage for a change in the diagnostic paradigm for cardiac allograft vasculopathy and advance our understanding of the pathophysiologic mechanism for the disease that impacts the majority of heart transplant recipients.

PI_NAMEs: CLERKIN, KEVIN J (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Adult;Affect;American;Angiography;Antibodies;Arteries;atherosclerosis risk;B-Lymphocytes;biobank;Biopsy;Blood Cells;Blood flow;blood flow measurement;Blood specimen;Blood Vessels;Cardiac;Cardiac Catheterization Procedures;Cardiology;career;career development;Catheterization;Cause of Death;Cells;Cessation of life;chemokine;Clinical;Clinical Research;Clinical Trials Design;Clone Cells;Coronary;Coronary Angiography;Coronary Arteriosclerosis;Coronary artery;cytokine;Cytokine Gene;Data;Detection;Development;Development Plans;Diagnosis;Diagnostic;Diagnostic Procedure;Diffuse;Disease;Dobutamine Stress Echocardiography;Epicardium;Event;Exhibits;experience;Fibrosis;follow-up;Functional disorder;Future;Gene Mutation;Genes;Gifts;Goals;Guidelines;heart allograft;Heart failure;heart imaging;Heart Transplantation;Hematology;Hematopoiesis;Human;Image;Immune;Impairment;improved;Individual;individual patient;Infiltration;Inflammation;Inflammatory;Innate Immune Response;Ischemia;K-Series Research Career Programs;Life;Macrophage;Measurement;Measures;Mediating;meetings;Mentors;Mentorship;Modality;mortality;mouse model;multidisciplinary;multimodality;novel;novel diagnostics;Organ;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Perfusion;peripheral blood;Persons;Phenotype;Physicians;Physiology;Plasma Cells;Population;Positioning Attribute;Positron-Emission Tomography;post-transplant;pressure;prognostic;Proliferating;Recommendation;Research;research data dissemination;Research Personnel;research study;Research Training;retransplantation;Risk;Risk Factors;routine screening;screening;Smooth Muscle;standard care;Stress Tests;targeted treatment;Testing;Thick;Training;Translational Research;translational study;Transplant Recipients;Transplantation;Transplantation Immunology;United States;Vascular Diseases;Work

PROJECT_TITLE: Identifying Novel Diagnostics and Mechanisms for Cardiac Allograft Vasculopathy

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ORG_CITY: CHESTNUT HILL

ORG_DEPT: CHEMISTRY

ORG_NAME: BOSTON COLLEGE

PHR: Project Narrative. Single-enantiomer chiral compounds are vitally important as new materials and as medicinally relevant therapies. The proposed research will develop new technologies for the construction of such compounds from simple, readily available natural resources.

PI_NAMEs: MORKEN, JAMES PATRICK (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Address;Coupling;enantiomer;Equipment;functional group;Medicine;Natural Resources;new technology;Organic Synthesis;Process;Reagent;Research;Techniques

PROJECT_TITLE: New Strategies in Catalytic Organic Synthesis with Organoboron Reagents


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Rare Diseases

ORG_CITY: DALLAS

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative The absence of Fragile X Mental Retardation Protein (FMRP) results in the most common single gene cause of hereditary autism spectrum disorder, which is also associated with hypersensitivity to sounds. We will investigate how FMRP regulates gene expression in the developing auditory system that may modulate neuroplasticity. Results may reveal therapeutic targets to treat hypersensitivity to or abnormal processing of sounds.

PI_NAMEs: SAKANO, HITOMI  (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Affect;Age;Antibodies;Auditory;auditory deprivation;auditory pathway;Auditory system;autism spectrum disorder;Binding;Binding Proteins;Biology;Brain;Brain region;Brain Stem;Cochlear nucleus;Collaborations;Data;deafness;Development;Diphtheria Toxin;Disease;Exhibits;experience;Fibroblasts;FMR1 gene;Fragile X Syndrome;Gene Expression;Gene Expression Regulation;gene repression;General Population;Genes;glutamatergic signaling;Goals;Heritability;Hyperacusis;Hypersensitivity;induced pluripotent stem cell;Inherited;inhibitor;Knock-out;Knockout Mice;Loudness;Measures;Mediating;Mentors;Messenger RNA;Methods;Modeling;Molecular Biology;mouse model;mRNA Decay;mRNA Precursor;mRNA Translation;Mus;Neuronal Plasticity;Neurons;Noise;novel;Pathway interactions;Patients;Phenocopy;Phenotype;Phosphorylation;Population;postnatal;Process;protein function;Proteins;Proxy;Publishing;Quantitative Reverse Transcriptase PCR;Repression;Research;Research Personnel;response;RNA;RNA immunoprecipitation sequencing;Role;Seizures;small molecule;sound;Stains;Synapses;Techniques;Technology;Testing;Therapeutic;therapeutic target;Tissues;transcriptome;transcriptome sequencing;translation factor;Translational Repression;Translations;Western Blotting;Wild Type Mouse;Work

PROJECT_TITLE: Role of Fragile X Mental Retardation Protein on Gene Expression in Auditory Brainstem Development


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_DEPT: ANESTHESIOLOGY

PHR: Project Narrative: Opioid addiction extorts a tremendous toll on society, but a mechanistic understanding of how repeated exposure to opioids such as heroin ultimately results in compulsive drug-taking and -seeking behavior in some individuals, but not others, is still not known. We will generate comprehensive datasets aimed at understanding how single- cell gene expression, circuit connectivity, and activity are impacted by previous heroin seeking behavior. These data will provide a much-needed cellular atlas and resource for the addiction neuroscience community, and will likely lead to the identification of many novel cell type specific genes that can be leveraged for future study.

PI_NAMEs: FERGUSON, SUSAN MARIE;STUBER, GARRET D (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: addiction;Address;Affect;Anatomy;Animal Behavior;Animal Model;Atlases;Behavior;behavioral phenotyping;Bioinformatics;Biological Assay;biomarker identification;Brain;brain cell;Brain region;brain tissue;Calcium;cell type;Cells;Chromatin;cohort;Communities;Cues;Data;Data Collection;Data Set;Development;Dorsal;drug development;Drug Exposure;Drug Modelings;drug seeking behavior;Drug usage;Exposure to;Fluorescent in Situ Hybridization;Future;Gene Expression;Gene Expression Profile;Gene Expression Profiling;gene network;Genes;Genetic Transcription;Heroin;Heroin Dependence;Human;Image;in vivo;in vivo calcium imaging;Individual;Individual Differences;Infusion procedures;Knowledge;Light;Maps;Measurement;Medial;Microscopy;Modeling;Molecular;molecular marker;Nature;Nervous System;neural;neural circuit;Neurons;Neurosciences;novel;Nucleus Accumbens;Opiate Addiction;Opioid;opioid use;Pattern;Pharmaceutical Preparations;Population;Process;Publishing;Rattus;Relapse;Research;Resolution;Resources;response;RNA;Sampling;Self Administration;Series;Signal Transduction;single cell sequencing;single-cell RNA sequencing;Slice;Societies;Standardization;System;Thalamic structure;therapeutic candidate;therapeutic target;Tissue-Specific Gene Expression;Tissues;Vulnerable Populations

PROJECT_TITLE: Transcriptional, functional, and circuit profiling at single cell resolution of neuronal ensembles engaged by heroin relapse


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Inflammatory Bowel Disease;Mental Health;Microbiome;Pain Research

PHR: Project Narrative Individuals with inflammatory bowel disease experience many symptoms which impact social and physical functioning as well as quality of life. Self-management interventions are needed to address the symptom burden experienced by individuals with inflammatory bowel disease. The proposed study has the potential to improve the self-management of this population.

PI_NAMEs: KAMP, KENDRA JOY (contact)

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: Abdominal Pain;acceptability and feasibility;Address;Adolescent;Age;Anxiety;anxiety symptoms;associated symptom;Behavioral;Biological;career;career development;Chronic;Chronic Disease;chronic inflammatory disease;Clinical Management;clinical phenotype;Clinical Trials;Cognitive Therapy;Competence;Conduct Clinical Trials;cost;Crohn's disease;Data;Data Collection;data management;Diagnosis;Diarrhea;Diet;Discipline of Nursing;Disease;Distress;Dropout;efficacy evaluation;efficacy testing;Ethnic Origin;experience;Fatigue;Foundations;Future;Gases;gastrointestinal;gastrointestinal symptom;Goals;gut microbiome;Health;health care service utilization;Healthcare Systems;holistic approach;improved;Individual;Inflammatory Bowel Diseases;innovation;Interdisciplinary Study;Intervention;intervention delivery;Intestines;Irritable Bowel Syndrome;Knowledge;Leadership;Learning;Leukocyte L1 Antigen Complex;Literature;Medical;Mental Depression;Mentorship;microbiome;microbiome analysis;Monitor;Muscle Cramp;Nurses;Outcome;Participant;Patients;Pharmaceutical Preparations;Physical Function;Pilot Projects;pilot test;Population;post intervention;Precision Health;Procedures;programs;psychological distress;Psychology;psychosocial;Psychosocial Factor;Quality of life;Race;Randomized;Randomized, Controlled Trials;recruit;Recurrence;reduce symptoms;Relaxation;Reporting;Research;Research Personnel;Resources;response;sample collection;Sampling;Science;Self Management;sex;skills;Sleep disturbances;sleep quality;Social Functioning;Solid;statistics;Subgroup;Symptom Burden;symptom management;symptom science;Symptoms;Training;treatment as usual;trial design;Ulcerative Colitis;Universities;Washington;Work;young adult

PROJECT_TITLE: A Comprehensive Self-Management Intervention for individuals with Inflammatory Bowel Disease

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(82)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: Project Narrative Experiments proposed in this application will study the potential of a naturally occurring nucleotide, that activates the contractile protein myosin (dATP), to increase the performance of the heart. We have produced heart muscle cells derived from human stem cells that have elevated dATP (donor cells) and will determine how these donor cells affect ventricular function when transplanted into rodent hearts after a myocardial infarction. We will also determine how dATP affects the muscle contractile protein myosin that uses it to increase contraction.

PI_NAMEs: REGNIER, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Actins;Affect;ATP phosphohydrolase;ATP Synthesis Pathway;Award;Behavior;Binding;Binding Sites;Canis familiaris;Cardiac;Cardiac Myocytes;Cardiac Myosins;cardiac repair;Cell Line;cell replacement therapy;Cell Survival;Cell Transplantation;Cells;Cellular Metabolic Process;Chronic;Computer Models;Congestive Heart Failure;Contractile Proteins;Contracts;Data;Dependence;Depressed mood;Development;Disease;Dose;Electrostatics;engineered stem cells;Engineering;Engraftment;Enzymes;Equilibrium;experimental study;Family suidae;functional improvement;Funding;Gap Junctions;Genes;Genetic Transcription;Goals;Heart;Heart failure;heart function;Human;Human Engineering;human induced pluripotent stem cells;human stem cell-derived;human stem cells;imaging approach;improved;improved outcome;In Vitro;induced pluripotent stem cell;Infarction;inhibitor;Ischemia;Kinetics;Left;Left Ventricular Function;Macaca nemestrina;Mechanics;Mediating;Microscopy;Modeling;Molecular;molecular dynamics;Movement Disorders;multi-scale modeling;Mus;Muscle;Muscle Cells;Muscle Contraction;Muscle relaxation phase;Myocardial;Myocardial Infarction;Myocardium;Myosin ATPase;nonhuman primate;novel;Nucleotides;Nude Rats;overexpression;Pathology;Pathway interactions;Performance;Perfusion;Phosphocreatine;Phosphorylation;Physiologic intraventricular pressure;Positioning Attribute;pressure;promoter;Proteins;Publishing;Rattus;Recovery;recruit;Relaxation;Reperfusion Injury;Reporting;Rest;Ribonucleotide Reductase;Rodent;Rodent Model;Roentgen Rays;Sarcomeres;single molecule;small molecule;small molecule therapeutics;stem cells;Stimulant;Structure;targeted treatment;Testing;Thick Filament;Thin Filament;time use;Tissues;Transgenic Mice;Transgenic Organisms;Transplantation;ultra high resolution;Ventricular;Ventricular Function;Vertebral column;Viral Vector;Work;X ray diffraction analysis

PROJECT_TITLE: Engineered Stem Cells for Cardiac Repair

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Depression;Endocannabinoid System Research;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: CHICAGO

ORG_DEPT: PSYCHIATRY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Mood and anxiety disorders are the most prevalent psychiatric illnesses and exert substantial personal and economic burden worldwide. Existing treatments for affective illnesses are only partially effective. Here we aim to elucidate a role for endogenous cannabinoid lipids in the regulation of mood, anxiety and stress responsivity with the ultimate goal of validating endogenous cannabinoid augmentation as a new approach to the treatment of mood and anxiety disorders.

PI_NAMEs: PATEL, SACHIN  (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: 2-arachidonylglycerol;Acute;Affect;Affective;Amygdaloid structure;Anxiety;Anxiety Disorders;anxiety-related behavior;avoidance behavior;Award;Behavior;Behavioral;biobehavior;biological adaptation to stress;Biosensor;Calcium;Cells;CNR1 gene;Complex;conditioned fear;Coupling;Cues;Data;Development;Disease;Economic Burden;Effectiveness;Electrophysiology (science);endocannabinoid signaling;Endocannabinoids;endophenotype;Enzymes;Extinction;Fright;Functional disorder;G-Protein-Coupled Receptors;Generations;Genetic;genetic approach;Glutamates;Goals;Hippocampus;Image;imaging approach;Impairment;in vivo;Individual;innovation;insight;Learning;Link;Lipids;lipoprotein lipase;Long-Term Depression;Major Depressive Disorder;Mediating;Mental Depression;mental development;Mental disorders;Molecular;Monoacylglycerol Lipases;Mood Disorders;mood regulation;neural;neural circuit;Neurons;neuropsychiatric disorder;novel;novel strategies;optogenetics;Pathologic;Pathology;pharmacologic;physiologic stressor;Physiological;Play;Population;Population Dynamics;Post-Traumatic Stress Disorders;Predisposition;Prefrontal Cortex;Process;psychological stressor;Psychopathology;Regulation;resilience;response;Risk Factors;Role;Shapes;Signal Induction;Signal Transduction;Specificity;Stress;stress reduction;stress related disorder;stress resilience;Substance Use Disorder;Synapses;synthetic enzyme;Techniques;Testing;Time;Translating;Translations;Viral;Work

PROJECT_TITLE: 2-Arachidonoylglycerol signaling in anxiety, depression, and stress adaptation

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


NIH_SPENDING_CATS: Genetics;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: Project Narrative Transplantation of hematopoietic (blood-forming) stem cells is a life-saving therapy used to cure blood and immune disorders. However, not all patients in need of hematopoietic stem cell transplantation have suitable donors of these precious cells. To overcome this obstacle, the research in this proposal seeks to identify the instructions that guide the initial formation of hematopoietic stem cells during development in order to replicate their production in the laboratory.

PI_NAMEs: HADLAND, BRANDON K (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Address;Biological Assay;Blood;Blood Vessels;Cell Cycle;Cell Therapy;cell type;Cells;Cellular Assay;chemokine;chemokine receptor;Coculture Techniques;combinatorial;CRISPR/Cas technology;CXCR4 gene;Development;differentiation protocol;disease model;Dose;Embryo;Embryonic Development;endothelial stem cell;Endothelium;Endowment;Engraftment;Gene Expression;Gene Expression Profile;Generations;Genes;Genetic;Genetic Transcription;Goals;Hematological Disease;Hematopoiesis;Hematopoietic;Hematopoietic Cell Production;hematopoietic differentiation;hematopoietic engraftment;hematopoietic stem cell differentiation;hematopoietic stem cell emergence;hematopoietic stem cell fate;hematopoietic stem cell formation;Hematopoietic Stem Cell Research;Hematopoietic Stem Cell Specification;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;hematopoietic transplantation;hemogenic endothelium;human pluripotent stem cell;Immune System Diseases;In Vitro;in vivo;indexing;inducible Cre;innovation;insight;Instruction;interest;Knowledge;Laboratories;Life;life span;Ligands;loss of function;Measures;Mediating;Metabolic;Methods;Mitotic;Mitotic Activity;Modeling;Molecular;Mus;MYC Family Protein;Natural Killer Cells;novel strategies;Pathway interactions;Patients;pharmacologic;pluripotent stem cell differentiation;Pluripotent Stem Cells;Production;programs;Property;protein expression;Protocols documentation;receptor;Reproducibility;Research;Resolution;Resources;Role;self-renewal;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Sorting;Specific qualifier value;Stem Cell Development;stem cells;Stromal Cell-Derived Factor 1;success;Surface;T-Lymphocyte;Techniques;Testing;Therapeutic;transcriptomics;Transplantation

PROJECT_TITLE: Dormancy-dependent determination of hematopoietic stem cell fate from hemogenic endothelium

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Project Narrative  It has been hypothesized that dysfunction of brain hubs underlies brain network changes and neuro- pathophysiology of numerous brain disorders, but directly testing this hypothesis in humans is challenging. The proposed research will elucidate the causal impact of short-term and long-term suppression of a hub on brain network organization, function and behavior using an awake rodent model. Such knowledge will help reveal the neural substrates causing large-scale brain network changes, and provide insight into understanding the neuro- pathophysiology of brain disorders.

PI_NAMEs: ZHANG, NANYIN  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Acute;Affect;Animal Behavior;Animals;Anterior;area striata;awake;Behavior;behavior test;Behavioral;Brain;Brain Diseases;brain dysfunction;Brain region;cell type;Chronic;cingulate cortex;Clozapine;Complex;Data;designer receptors exclusively activated by designer drugs;Dorsal;Electrophysiology (science);Equilibrium;Functional disorder;Functional Magnetic Resonance Imaging;Global Change;Goals;Grant;Hour;Human;insight;Knowledge;Measures;Mediating;Mental disorders;millisecond;Modeling;Monitor;Monkeys;neural;neural network;Neurons;optogenetics;Oxides;Pathway interactions;Play;Process;Property;Rattus;Research;Rest;Rodent;Rodent Model;Role;Signal Transduction;Site;spatiotemporal;Specificity;Synapses;System;Testing;Time;tool

PROJECT_TITLE: Resting-state Neural Networks in Awake Rodents


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Neurosciences;Pediatric

ORG_CITY: Newark

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Project Narrative The proposed research is relevant to public health because advancing our understanding of the neuroanatomical, neurophysiological and behavioral heterogeneity in developmental stuttering is expected to elucidate the disorder’s complex etiology and form the foundation for developing customized treatment approaches to target individual neurological and behavioral deficits associated with stuttering. Thus, the proposed research is relevant to NIDCD’s mission that pertains to improving the lives of people with communication disorders.

PI_NAMEs: CHOW, HO MING  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Affect;Anatomy;Area;Basal Ganglia;Behavior;Behavioral;Brain;Cerebellum;Child;Clinical;Communication impairment;comorbidity;comparison control;Complex;Data;Development;Developmental Course;Developmental Stuttering;Discrimination;Disease;Disfluent;Etiology;Exhibits;Foundations;Functional Magnetic Resonance Imaging;Genetic;Goals;gray matter;Heterogeneity;Image;improved;Individual;individualized medicine;Knowledge;Language;Left;Link;Magnetic Resonance Imaging;Methods;Mission;Modeling;morphometry;Motor;motor control;National Institute on Deafness and Other Communication Disorders;neural;Neuroanatomy;Neurologic;Neurologic Deficit;neurophysiology;Neurosciences;novel therapeutic intervention;Outcome;Pattern;Performance;Periodicity;Persons;Phenotype;Phonation;Production;Public Health;Research;Severities;Source;Speech;Speech Acoustics;Speech Disorders;Structural defect;Structure;Stuttering;System;Testing;Time;translational impact;United States

PROJECT_TITLE: Neural subtypes of developmental stuttering


NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: Project Narrative Nanodiscs, nanometer scale lipid bilayers encircled by two amphipathic protein belts have proven to be enabling for investigations involving membranes and membrane proteins. This award will support further research using the Nanodisc platform to understand the structure and function of membrane proteins and the interaction of proteins with membrane surfaces.

PI_NAMEs: SLIGAR, STEPHEN G. (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Adrenal Glands;Architecture;Award;Binding;Biochemical;biochemical tools;Biological;Biophysics;Catalysis;cell motility;Cells;Communication;Complex;Cytochrome P450;drug metabolism;Environment;Event;Generations;Guanosine Triphosphate Phosphohydrolases;Home;hormone biosynthesis;Human;Investigation;Laboratories;Life;Lipid Bilayers;Lipids;Liver;Malignant Neoplasms;Mediating;Membrane;Membrane Proteins;Membrane Structure and Function;Metabolism;Methodology;Molecular;Molecular Biology;molecular recognition;nanodisk;nanoscale;novel;Peptides;protein function;Proteins;Research;Role;Scaffolding Protein;self assembly;Signal Transduction;Site;Surface;Surface Antigens;Synapses;System;Vinculin;Viral Antigens

PROJECT_TITLE: Nanoscale Approaches to Understanding Membrane Protein Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: The current application proposes studies to elucidate the mechanisms, role and importance of senescent A1 astrocytes and microglia in chronic neuroinflammation after traumatic brain injury (TBI). Preclinical studies are also proposed to determine the therapeutic efficacy of targeting senescent A1 astrocytes and microglia to inhibit chronic neuroinflammation and improve long-term outcome after TBI. If successful, the studies could provide hope of a therapy that could be used months or even years after TBI, where there are now no treatment options.

PI_NAMEs: BRANN, DARRELL W (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Ablation;Acute;Agonist;Alzheimer's Disease;Astrocytes;Brain;Brain Injuries;Brain region;Cause of Death;Cell Death;cell injury;Cells;Chronic;Chronic Disease;Complement;Complement 1q;Data;disability;dopaminergic neuron;functional decline;functional outcomes;GLP-I receptor;Health;Huntington Disease;Impaired cognition;improved;Individual;Inflammation;Inflammatory;innovation;Interleukin-1 alpha;Ischemia;Knockout Mice;Light;Microglia;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;neuroinflammation;neuron loss;Neurons;neuropathology;neuroprotection;neurotoxic;novel;novel therapeutics;Oligodendroglia;Outcome;Parkinson Disease;Pathologic Processes;Pathology;Pharmaceutical Preparations;Pharmacotherapy;Play;preclinical study;progressive neurodegeneration;release factor;Research;Resistance;Role;senescence;senescent cell;senolytics;stressor;Supportive care;Synapses;TBI treatment;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;therapeutic target;transcriptome;transcriptome sequencing;transcriptomic profiling;Trauma;Traumatic Brain Injury;Treatment Efficacy;United States;white matter;white matter damage;Work

PROJECT_TITLE: Mechanisms and Therapeutic Targeting of Chronic Neuroinflammation in Traumatic Brain Injury

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: BALTIMORE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Cellular force sensing is essential for the proliferation of cells, normal development, and maintenance of a healthy organism. We seek to decipher how mechanical forces direct the localized assembly of key mechanosensory machinery, including nonmuscle myosin II proteins, and how these cellular responses lead to changes in cell behavior and identity.

PI_NAMEs: IGLESIAS, PABLO A.;ROBINSON, DOUGLAS N (contact);ROCK, RONALD S

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Actins;Adhesions;Affect;Biochemical Process;Biological Models;cell behavior;Cell Cycle Stage;Cell division;cell motility;Cell Physiology;Cell Proliferation;Cell Shape;cell type;Cells;cellular engineering;Complex;Computational Biology;Computer Models;Contractile System;cortexillin I;Cytoplasm;Cytoskeletal Proteins;Cytoskeleton;Data;Development;Dictyostelium;Diffusion;Elasticity;Environment;Evolution;Feedback;Filament;force sensor;Gene Expression;Goals;Growth;Heterogeneity;Human;in vivo;insight;Kinetics;Lead;Learning;Location;Magnetism;Maintenance;Mass Spectrum Analysis;mathematical model;Measures;mechanical force;mechanical stimulus;Mechanical Stress;Mechanics;mechanotransduction;Mediating;Microscopy;Modeling;Molecular;Monitor;Morphogenesis;Motility;Motion;Motor;Myosin ATPase;Myosin Heavy Chains;Myosin Type II;myosin-heavy-chain kinase;non-muscle myosin;Nonmuscle Myosin Type IIA;Nonmuscle Myosin Type IIB;Normal Cell;Organism;Outcomes Research;Output;particle;Phosphorylation;Phosphorylation Site;Phosphotransferases;Positioning Attribute;Process;programs;Property;protein crosslink;Protein Isoforms;Proteins;Publishing;Regulatory Pathway;Relaxation;Research;response;Role;Science;Shapes;Signal Pathway;Signal Transduction;simulation;single molecule;Site;System;Testing;theories;therapeutic development;Thick Filament;Time;Tissues;Variant;Work

PROJECT_TITLE: Molecular Mechanisms of Cytoskeletal Mechanosensory Systems