NIH_SPENDING_CATS: Chronic Pain;Genetics;Human Genome;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_DEPT: ANESTHESIOLOGY

PHR: Project Narrative Poorly managed pain creates an enormous burden on our healthcare system and produces tremendous human suffering. This research program focuses on mechanisms that promote chronic pain to gain a better understanding of disease mechanisms for the eventual development of more effective therapeutics. We plan to utilize cutting edge, unbiased methods for the detection of novel pain plasticity signaling pathways that we anticipate will have a broad impact on the neurosciences.

PI_NAMEs: CAMPBELL, ZACHARY  (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: 5' Untranslated Regions;Acute;Address;Animals;Attenuated;Behavior;Binding;biological adaptation to stress;Chemicals;Chronic;chronic pain;chronic pain management;Codon Nucleotides;Cues;cytokine;Data;detection method;Development;Diabetic Neuralgia;Diabetic Neuropathies;Disease;Electrophysiology (science);Endoplasmic Reticulum;endoplasmic reticulum stress;Event;experimental study;Exposure to;FRAP1 gene;Generations;Genes;Genetic;Genome;genome-wide;genomic tools;Genomics;Goals;Healthcare Systems;High-Throughput Nucleotide Sequencing;Human;Hyperalgesia;Hypersensitivity;Immediate-Early Genes;Impairment;improved;in vivo;Inflammation Mediators;Inflammatory;inflammatory pain;inhibitor;insight;Institute of Medicine (U.S.);interest;Life;Link;Maps;Mechanics;Messenger RNA;Methods;Modeling;Molecular;Morals;Neuronal Plasticity;Neurons;Neuropathy;Neurosciences;Nociception;Nociceptors;novel;Open Reading Frames;Pain;Pain management;painful neuropathy;Pathway interactions;Pattern;Peptides;Peripheral;Persistent pain;pharmacologic;Pharmacology;Phase;Phenotype;Phosphorylation;Play;Population;Postoperative Pain;Production;programs;Protein Biosynthesis;Pyruvaldehyde;Reading Frames;Regulation;Research;Resolution;response;Ribonucleases;ribosome profiling;Ribosomes;RNA;Role;Shapes;Signal Pathway;Signal Transduction;Spinal Ganglia;Structural Protein;Synaptic plasticity;targeted treatment;therapeutically effective;Tissues;Transcript;transcriptome;Translating;Translation Initiation;Translational Regulation;Translations;translatome;United States;Untranslated Regions;virtual

PROJECT_TITLE: Profiling Translation in Nociceptor Plasticity

STUDY_SECTION: SPS

STUDY_SECTION_NAME: Somatosensory and Pain Systems Study Section[SPS]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Physical Activity;Prevention;Telehealth

ORG_CITY: CHAPEL HILL

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MISCELLANEOUS

ORG_FIPS: US

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Weight gain is disproportionately high among young adults (18-35) compared to other age groups, and of particular concern in the military, which is comprised largely of young adults, as obesity has emerged as a threat to national security. Despite the critical need to address weight gain in young military personnel who can face discharge for failing to meet weight standards, there is currently no evidence-based treatment available to them. This study aims to adapt an evidence-based weight gain prevention intervention for delivery in a young adult, active-duty military population using mobile technology to prevent weight gain over 2 years.

PI_NAMEs: TATE, DEBORAH F. (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Accelerometer;active duty;Address;Adoption;Age;age group;Air;Air Force Personnel;behavior change;Body mass index;Body Weight Changes;Body Weight decreased;Cellular Phone;Color;comparison control;Control Groups;Department of Defense;design;Diet;digital;Education;effectiveness evaluation;effectiveness study;effectiveness trial;Employee;Ethnic Origin;Evaluation;evidence base;Evidence based treatment;experience;Face;Feedback;Female;fitness;Gender;General Population;healthy weight;Hybrids;Income;Internet;Intervention;intervention delivery;Leadership;Life Style;Maintenance;Measures;men;mHealth;mhealth interventions;Military Personnel;military service;mobile application;mobile computing;mobile phone based intervention;Monitor;National Security;novel;novel strategies;Obesity;Outcome;Overweight;Periodicals;Persons;Phase;Physical activity;preference;prevent;Prevention trial;preventive intervention;primary outcome;Primary Prevention;Process;Professional counselor;programs;psychosocial;Public Health;Race;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;recruit;remote delivery;Reporting;Research;Risk Factors;Sampling;service member;Site;smart scale;sound;success;Surface;System;Techniques;Telephone;Testing;Thinness;Time;tool;Training;Translations;treatment effect;trial design;Underserved Population;United States;Weight;Weight Gain;weight gain prevention;Weight maintenance regimen;Woman;young adult

PROJECT_TITLE: Preventing weight gain in U.S. Air Force personnel using a novel mobile health intervention

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: AI

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Pediatric;Pneumonia;Pneumonia and Influenza;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: ROCKEFELLER UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative We reported that at least 13.5% of patients with life-threatening COVID-19 have inborn errors of TLR3- and IRF7-dependent type I IFN immunity, or neutralizing auto-Ab against type I IFNs. We now hypothesize that other genetic defects of production, activity, or impact of type I IFNs can underlie life-threatening COVID-19 in other patients. Our preliminary data suggest that these different forms of IEI impairing anti-viral type I IFN immunity can underlie life-threatening COVID-19 in a sizeable proportion of cases.

PI_NAMEs: CASANOVA, JEAN-LAURENT  (contact);ZHANG, QIAN ;ZHANG, SHEN-YING

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: 2019-nCoV;Age;aged;Autoantibodies;Autoimmune;autosome;B-Lymphocytes;Biological;Biological Assay;Bloch Sulzberger syndrome;Case Study;Categories;CD4 Positive T Lymphocytes;Cell Line;Cell model;Cells;Clinical;cohort;Collaborations;Communicable Diseases;comorbidity;congenital immunodeficiency;COVID-19;COVID-19 patient;COVID-19 pneumonia;Data;Defect;Disease;Epidemiologic Factors;Ethnic Origin;Fatality rate;Fibroblasts;Future;Gender;Genes;Genetic;Genetic Heterogeneity;Genetic study;genomic data;Hereditary Disease;Heterozygote;Human;Human Genetics;IFNAR1 gene;Immunity;Impairment;In Vitro;Individual;Infection;Influenza;influenza pneumonia;Interferon alpha;Interferon Type I;Interferon-beta;Interferons;International;Leucine-Rich Repeat;Life;Link;loss of function;male;Medical;men;Monoclonal Antibodies;multiplex assay;Mutation;Nebulizer;novel diagnostics;novel therapeutic intervention;Other Genetics;Pathogenesis;Pathway interactions;Patient Selection;Patients;Penetrance;Phenocopy;Plasmapheresis;Production;Productivity;programs;Proteins;Recording of previous events;recruit;Reporting;response;Rice;Risk;SARS-CoV-2 immunity;SARS-CoV-2 infection;sensor;Serum;Severe Acute Respiratory Syndrome;severe COVID-19;Severities;subcutaneous;Susceptibility Gene;T-Cell Development;Testing;TLR3 gene;Universities;Variant;Viral;Viral Physiology;viral RNA;Virulence;Virus;Virus Diseases;Woman;X Inactivation

PROJECT_TITLE: Inborn errors of immunity in patients with life-threatening COVID-19

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-N(90)]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative Photoreceptors are the main detectors of light that relay visual information to the brain. This proposal investigates the key molecular interactions that mediate selective wiring of photoreceptors to their respective synaptic targets. The long-term goal of this research is to uncover the molecular basis of retinal wiring in order to devise new forms of therapies to treat and restore vision.

PI_NAMEs: ZUNIGA-SANCHEZ, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Address;Adhesives;Axon;B-Lymphocytes;Binding;Bipolar Neuron;Blindness;Brain;Cell Adhesion Molecules;cell type;Central Nervous System;Clustered Regularly Interspaced Short Palindromic Repeats;CNTNAP1 gene;Complex;Cone;contactin;Data;Defect;Degenerative Disorder;Dendrites;detector;Development;developmental disease;Ectopic Expression;Electroporation;experimental study;Family;gain of function;genetic manipulation;Goals;horizontal cell;in vivo;Knowledge;Label;Light;loss of function;Mediating;Molecular;Nervous System Disorder;Neural Cell Adhesion Molecule L1;neural circuit;neurofascin;Neurons;NRCAM gene;organizational structure;Pathway interactions;Patients;Pattern;Photoreceptors;postsynaptic;Process;protein expression;Research;response;Retina;Retinal Cone;Retinal Diseases;retinal rods;rho;Rod;sight restoration;Specific qualifier value;Specificity;Synapses;synaptogenesis;Techniques;Testing;Transgenic Mice;transmission process;Vertebrate Photoreceptors;Visual;visual information;Work

PROJECT_TITLE: Deciphering the molecular mechanisms in photoreceptor wiring

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: ITHACA

ORG_DEPT: NUTRITION

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE Proper regulation of gene expression is critical for the function of all cells and transcription and translation are two main pillars of gene expression. When this coordinated process is performed incorrectly, a variety of diseases can arise, including diabetes and cancer. This proposal aims to elucidate how translation pausing on mRNAs leads to transcriptional response, which forms a potential genetic circuit linking mRNA translation, degradation, and transcription.

PI_NAMEs: QIAN, SHU-BING  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Amino Acids;Cells;Chromatin;Communication;Compensation;Coupling;Cytoplasm;design;Diabetes Mellitus;Disease;epigenetic regulation;Eukaryota;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic information;Genetic Transcription;Goals;Link;Malignant Neoplasms;Maps;Mediating;Messenger RNA;Methods;Molecular;Molecular Biology;mRNA Translation;novel;novel therapeutics;Nuclear;Process;Production;Proteins;Research;response;Ribosomes;RNA;Route;Starvation;Stress;Translations;transmission process;Up-Regulation

PROJECT_TITLE: A Genetic Circuit Formed by Ribosomes


NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: MOBILE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTH ALABAMA

ORG_STATE: AL

PHR: PROJECT NARRATIVE Dysfunction of the endothelial cell layer lining blood vessels is the hallmark of cardiovascular disease. This project focuses on characterizing and correcting the transition of the endothelial cell network to an anomalous signaling signature that promotes progressive and irreversible vascular disease. Specifically, we will employ novel imaging and high-content analysis approaches as well as state-of-the-art molecular, genetic and functional assessments to define crucial therapeutic targets for maintaining a healthy endothelial Ca2+ profile and preventing endothelial dysfunction and vascular remodeling.

PI_NAMEs: TAYLOR, MARK STEPHEN (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Abate;Arteries;Atherosclerosis;Blood flow;Blood Vessels;Calcium-Activated Potassium Channel;Cardiovascular Diseases;Cardiovascular system;Carotid Arteries;Cell membrane;Cessation of life;Chronic;Chronic Disease;Clinical;Complex;confocal imaging;Coupling;Data;Development;Distal;Endoplasmic Reticulum;Endothelial Cells;endothelial dysfunction;Endothelium;Event;Exhibits;extracellular;Feedback;Fire - disasters;Frequencies;functional loss;G-Protein-Coupled Receptors;Genetic;Hemostatic function;Homeostasis;Human;Hypertension;Image;Impairment;Inflammation;inorganic phosphate;Inositol;Intervention;Island;ITPR1 gene;Knockout Mice;Lead;Ligation;Liquid substance;Modeling;Molecular;mouse model;Mus;novel;novel therapeutics;Obstruction;Pathologic;Pathology;Patients;Pattern;Peripheral;Peripheral arterial disease;Permeability;Phenotype;Physiological;Play;Potassium Channel;preservation;prevent;receptor;response;Role;shear stress;Signal Transduction;Specificity;Structure;therapeutic target;Time;TRP channel;Tunica Intima;Vascular Diseases;Vascular remodeling;vasoconstriction;Vasodilation

PROJECT_TITLE: Network signature of low-flow endothelial dysfunction

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE: Genetic mutations of RHO is the most common cause of autosomal dominant retinitis pigmentosa, an acquired blindness affecting over 1.5 million people worldwide whose life qualities are significantly affected due to a lack of effective drug treatments. The results of this study will demonstrate the feasibility and potential of using novel chemical modulators of rhodopsin protein homeostasis in treating this disease. The success of identifying a potent drug candidate will provide general therapeutic implications for treating inherited blindness due to protein misfolding.

PI_NAMEs: CHEN, YUANYUAN  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Acquired Blindness;Acute;Affect;Age;Anabolism;Animal Model;Anti-Inflammatory Agents;autosome;Biochemical;Biochemistry;biomaterial compatibility;Blindness;Cell Count;Cell Culture Techniques;Cell Death;Cell Survival;Cells;Cellular Stress;Cessation of life;chemical genetics;Chemicals;Chronic;Clinical;Clinical Trials;Data;design;Development;Disease;DNA Sequence Alteration;Dose;drug candidate;Drug Kinetics;Drug Targeting;effective therapy;efficacy evaluation;Electrophysiology (science);Encapsulated;Event;Eye;Future;G-Protein-Coupled Receptors;Genes;Genetic study;glial activation;glycosylation;Goals;high resolution imaging;high throughput screening;Homeostasis;Image;imaging modality;Immune response;improved;In Vitro;in vivo;Inflammation;Inflammatory;Inherited;inherited retinal degeneration;insight;intravitreal injection;Knock-in Mouse;Lead;Learning;lens;Light;Lysosomes;Mediating;Metabolism;Methotrexate;Microspheres;Modeling;Molecular;Molecular Chaperones;Morphology;mouse model;Mus;mutant;Mutation;Night Blindness;novel;Pathway interactions;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pharmacology Study;Pharmacotherapy;Photoreceptors;preservation;prevent;protein degradation;protein misfolding;proteostasis;Protocols documentation;Quality of life;receptor;Regimen;Retina;Retinal Degeneration;Retinal Diseases;retinal imaging;Retinal Pigments;retinal rods;Retinitis Pigmentosa;Rheumatoid Arthritis;Rhodopsin;Rod;Rod Outer Segments;Rodent Model;Role;Safety;small molecule;Stress;Structure;success;System;Techniques;Testing;Therapeutic;therapeutic target;tool;trafficking;transcriptome;transcriptome sequencing;transcriptomics;treatment strategy;United States Food and Drug Administration;Vision

PROJECT_TITLE: Pharmacological studies of rhodopsin metabolism

STUDY_SECTION: BVS

STUDY_SECTION_NAME: Biology of the Visual System Study Section[BVS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Maternal Health;Pediatric;Pregnancy;Rare Diseases;Vector-Borne Diseases;Women's Health Research;Zika Virus

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Maternal Zika virus (ZIKV) infection can cause severe damage to the developing fetus. The factors that are involved in susceptibility to ZIKV infection during pregnancy are currently unknown. In this application, we will investigate how antibodies against dengue virus enhance infection and pathogenesis of Zika virus in the context of pregnancy.

PI_NAMEs: LIM, JEAN KYOU (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Adult;Affect;Africa;Americas;Antibodies;Antibody Specificity;Antibody-Dependent Enhancement;Anxiety;Area;Asia;Binding;Biological Models;Birth;Brain;Brazil;Cells;Central American;Cognition;cohort;conditional knockout;Congenital Abnormality;Country;cross reactivity;Culicidae;Data;Dengue;Dengue Virus;Dependence;Development;Disease;Disease Outbreaks;Disease Outcome;Fc Receptor;fetal;Fetal Development;Fetus;Fever;Flavivirus;Geography;Human;IgG1;IgG2;IgG3;IgG4;Immunity;Immunocompetent;Immunocompromised Host;Immunoglobulin G;in utero;in vivo;Individual;Infection;Knock-in;Knock-in Mouse;Knockout Mice;Learning;Link;Long-Term Effects;Low Birth Weight Infant;Maternal Health;Measures;Membrane;Membrane Proteins;Memory;Mental Depression;Microcephaly;Minor;Modeling;Molecular;mortality;Mothers;Motor;Mus;Neonatal;neonatal Fc receptor;offspring;Pacific Islands;Pathogenesis;Placenta;placental trophoblasts;Populations at Risk;Predisposition;Pregnancy;pregnant;Proteins;pup;Reflex action;Role;Sensory;seropositive;Serotyping;Social Behavior;South America;South American;Spontaneous abortion;STAT2 gene;Surface;Symptoms;Testing;transmission process;trophoblast;Variant;Virion;Virus;Vision;Zika Virus;ZIKV disease;ZIKV exposure;ZIKV infection

PROJECT_TITLE: Enhanced susceptibility to Zika virus during pregnancy: a role for maternal dengue antibodies

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cachexia;Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: ROCHESTER

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative Skeletal muscle wasting (SMW) is a growing burden among cancer survivors, and is prognostic of treatment failure, radiotherapy toxicity, and a shorter time to tumor progression related to survival. This is a training grant to develop a young investigator into an independent scientist who will be investigating the mechanisms responsible for cancer- related muscle wasting and developing interventions.

PI_NAMEs: COLE, CALVIN LLOYD (contact)

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: Affect;Animals;Area;Attenuated;Autopsy;Biological Assay;bioluminescence imaging;Body Composition;C57BL/6 Mouse;Cancer Cachexia;Cancer Survivor;Catabolism;CCL2 gene;CD80 gene;Cells;chemokine;Chemotherapy and/or radiation;Chronic;cohort;cytokine;density;Development;Digestive System Disorders;Disease;Disease Progression;Dose;Dual-Energy X-Ray Absorptiometry;efficacy evaluation;Enzyme-Linked Immunosorbent Assay;Euthanasia;Exhibits;Fiber;Gene Expression;Genetic Markers;Grant;Growth Factor;Harvest;Histology;Human;human disease;Human Pathology;Immune;immune cell infiltrate;Implant;improved;in vivo;Infiltration;Inflammation;Inflammatory;inhibitor;Injections;Insulin-Like Growth Factor Binding Protein 3;Interleukin-12;Interleukin-6;interstitial;Intervention;Intramuscular;Knockout Mice;Laminin;Letters;lipid biosynthesis;Lipids;Luciferases;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;Malnutrition;Measures;Microspheres;Modeling;Molecular;mouse model;Mus;Muscle;Muscle Fibers;Muscular Atrophy;myogenesis;Myomatous neoplasm;Nebraska;novel;Oils;Operative Surgical Procedures;Outcome;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;paracrine;Pathologic;Pathology;Pathway interactions;Patients;Phenotype;Pre-Clinical Model;Production;prognostic;programs;Protein Synthesis Inhibition;Proteolysis;quadriceps muscle;Quantitative Reverse Transcriptase PCR;Radiation therapy;Randomized;Regimen;Research;Research Personnel;RNA;Role;Sampling;Scientist;Serum;Signal Transduction;Site;Skeletal Muscle;skeletal muscle wasting;Solid Neoplasm;Stains;STAT3 gene;subcutaneous;Syndrome;Time;Tissue Sample;Tissues;Training;transcriptome sequencing;Treatment Failure;Treatment Protocols;Treatment-related toxicity;tumor;Tumor Burden;tumor growth;tumor microenvironment;tumor progression;Universities;Up-Regulation

PROJECT_TITLE: Training and Research on Mechanisms of Pancreatic Cancer Associated Muscle Wasting and Related Therapies

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: ANN ARBOR

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Excess opioid prescribing by healthcare providers, including surgeons, has played a major role in the current opioid epidemic. Rural health disparities compound the complexity of the opioid epidemic for rural surgical patients, necessitating the development of novel interventions in this population. This project will characterize unique factors contributing to excess opioid prescribing in rural surgical patients and adapt a multifaceted intervention to decrease excess prescribing for rural surgeons.

PI_NAMEs: BORZA, TUDOR  (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Engaging rural surgeons to enhance opioid stewardship

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: HARRISBURG

ORG_NAME: PENNSYLVANIA DEPARTMENT OF AGRICULTURE

PHR: Project Narrative The Pennsylvania Department of Agriculture is applying for Path B, Regulatory Funding Band 4 and Education and Inventory Funding Band 6 to implement FDA’s Produce Safety Rule standards for safe growing, harvesting, packing and holding of raw agricultural commodity produce that is grown in the state. Under FDA authority, PA educates, regulates and enforces the Produce Safety Rule under 21 CFR Part 112 and the FDA Food Safety Modernization Act (FSMA). Consequently, the funding from PAR-21- 174 will minimize the risk of foodborne illness to the consumers of covered produce grown in the state of Pennsylvania.

PI_NAMEs: SMITH, STEFANIE M (contact)

PROGRAM_OFFICER_NAME: FREDRICK, JEANETTE

PROJECT_TITLE: Path B Continued Development and Implementation of the Pennsylvania Department of Agriculture Produce Safety Program


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MILWAUKEE

ORG_NAME: VERSITI WISCONSIN, INC.

ORG_STATE: WI

PHR: PROJECT NARRATIVE Acute myeloid leukemia is an aggressive blood cancer that is typically incurable and fatal with current treatments. We have discovered that the survival of AML cells, unlike healthy white blood cells, depends on an enzyme called Sirtuin 5, for which there are no drug or targeted treatment options. We will thoroughly characterize the biology of Sirtuin 5 and simultaneously work to develop a drug to treat patients with acute myeloid leukemia.

PI_NAMEs: DEININGER, MICHAEL W. (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Allogenic;Apoptosis;Attenuated;BCL2 gene;Biochemical;Biological Availability;Biology;biomarker identification;Bone Marrow;branched-chain-amino-acid transaminase;cancer cell;Catabolism;CD34 gene;Cell Death;Cell Line;Cell Survival;Cells;chemotherapy;Clinical;clinical development;CRISPR/Cas technology;Data;Dependence;Development;Drug Targeting;Energy Metabolism;Enzymes;Equilibrium;Exhibits;exome sequencing;experience;Fatty Acids;flexibility;FLT3 gene;FLT3 inhibitor;Future;Gene Expression Profile;Genes;Genetic;Genotype;Glutamine;Glycolysis;Growth;Hematologic Neoplasms;Hematopoietic;Hematopoietic Neoplasms;Hematopoietic Stem Cell subsets;Hematopoietic stem cells;Homeostasis;Impairment;In complete remission;In Vitro;in vivo;inhibitor;Isocitrate Dehydrogenase;knock-down;Knock-out;Lead;leukemia initiating cell;leukemia treatment;Leukemic Cell;Leukemic Hematopoietic Stem Cell;leukemic stem cell;leukemogenesis;Leukocytes;Lysine;Malignant - descriptor;Metabolic;Metabolic Pathway;Metabolic stress;Metabolism;meter;Minor;Mitochondria;mitochondrial metabolism;MLL-AF9;mouse model;Mus;mutant;Myelogenous;Myeloid Leukemia;Myeloproliferative disease;nanomolar;new therapeutic target;novel;novel therapeutics;Oncogenes;Organ;oxidation;Oxidation-Reduction;Oxidative Phosphorylation;Patients;Permeability;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Prognosis;Proliferating;Reagent;Reduced Glutathione;Regulation;Relapse;relapse patients;Resistance development;resistance mutation;response;Role;Sampling;scaffold;segregation;Sirtuins;small hairpin RNA;Solid Neoplasm;Somatic Mutation;stable isotope;Stem cell transplant;stem cells;Stress;Superoxides;targeted treatment;Testing;Therapeutic;tool;transcriptome sequencing;tumor heterogeneity;Validation;Work

PROJECT_TITLE: Targeting the Metabolic Regulator SIRT5 in Acute Myeloid Leukemia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Q(02)M]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Microbiome;Orphan Drug;Prevention;Rare Diseases;Urologic Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: NARRATIVE Chlamydia trachomatis is the most common infectious cause of blindness in the world today and, despite mass drug administration (MDA)—part of the World Health Organization’s strategy to control the disease—rates of trachoma remain high. We lack a fundamental knowledge of the natural history of trachoma that include the interactions of the genetics of ocular Chlamydia species, the ocular microbial composition and host immune responses. The objective of this research is to elucidate the role of these factors in trachoma development post MDA among a cohort residing in the trachoma hyperendemic region of Amhara, Ethiopia, that will aid in designing strategies to eliminate and prevent this devastating disease, especially among neglected populations in Africa.

PI_NAMEs: DEAN, DEBORAH ANNE (contact);READ, TIMOTHY D.

PROGRAM_OFFICER_NAME: CONNOLLY, KRISTIE LEE

PROJECT_TERMS: 10 year old;Adoption;Adult;Affect;Africa;Age;Algorithms;Anti-Inflammatory Agents;Antibiotics;Asia;Australia;Azithromycin;azithromycin resistance;Biological Response Modifiers;Blindness;burden of illness;Central America;Characteristics;Child;Chlamydia;Chlamydia trachomatis;cohort;Communicable Diseases;Communities;Country;Data;design;Development;Diagnostic;Disease;disorder control;dysbiosis;Epidemiologist;Ethiopia;Ethiopian;Eye;Eye diseases;Eyelash;Face;Genetic;genetic resistance;Genitourinary system;genome sequencing;Genomics;Geography;health disparity;host microbiota;Hygiene;Immune;Immune response;improved;Infection;Inflammation;Inflammation Mediators;Inflammatory Response;innovation;Intervention;Knowledge;member;metagenome;Metagenomics;Methods;microbial composition;microbial host;microbiome;microbiota;microbiota composition;Middle East;Minority;Modeling;Mutation;Natural History;neglect;novel therapeutic intervention;ocular microbiome;Operative Surgical Procedures;Organism;pathogen;pathogen genomics;Pathogenesis;Pathogenicity;Pharmaceutical Preparations;Phylogeny;Population;Populations at Risk;prevent;Price;Productivity;programs;Public Health;Qualifying;Regimen;Research;resistance gene;Resolution;Role;Sampling;Sanitation;Severities;Severity of illness;sex;Shotgun Sequencing;South America;South Sudan;Structure;Study Subject;Taxonomy;Therapeutic;therapy duration;Time;Trachoma;transmission process;treatment duration;Vision;Water;whole genome;Work;World Health Organization;Zoonoses

PROJECT_TITLE: Impact of ocular microbiome, immune response and Chlamydiae on trachoma following MDA

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


NIH_SPENDING_CATS: Biotechnology;Genetics;Hematology;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: BOSTON

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: PROJECT NARRATIVE Malaria is caused by infection of red blood cells (RBCs) with Plasmodium parasites and can result in severe or even fatal disease. Parasite polymorphisms that allow parasites to proliferate or persist in specific cell types present a major challenge to malaria disease control and elimination, respectively. Here, we propose to elucidate the molecular basis of two particular parasitic features that are of great public health importance, both for designing appropriate interventions and for anticipating the emergence of new strains into the population: the preference of P. falciparum for the youngest of human RBCs known as reticulocytes, and the adaptation of P. falciparum to human RBCs from gorilla cells.

PI_NAMEs: DURAISINGH, MANOJ T (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Age;Binding;Biomass;Blood;blood group;Blood typing procedure;Candidate Disease Gene;cell age;Cell surface;cell type;Cells;Cellular Tropism;Cessation of life;Circulation;design;Disease;disorder control;Erythrocytes;Exhibits;Family;forward genetics;Genes;genetic approach;Genetic Crosses;Genetic Polymorphism;Glycophorin;Gorilla gorilla;Growth;Hemoglobinopathies;Heterogeneity;Human;Humanities;Individual;Infection;Intervention;Invaded;Ligands;loss of function;Malaria;Maps;Mediating;member;Molecular;Morbidity - disease rate;mortality;Natural Selections;Parasites;Parasitic infection;Pathogenesis;Pathogenicity;Pathway interactions;Phenotype;Plasmodium;Plasmodium falciparum;Population;preference;Process;Productivity;Proliferating;Proteins;Public Health;public health intervention;Quantitative Trait Loci;receptor;Recombinants;Reticulocytes;reverse genetics;Role;Scourge;Sickle Hemoglobin;Staging;Therapeutic Intervention;therapy development;transmission process;Tropism;vaccine development;Variant

PROJECT_TITLE: Malaria parasite determinants of host cell tropism

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ORG_CITY: SPARKS

ORG_NAME: NEVADA STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: NV

PHR: Nevada Department of Agriculture Plant Industry Division Project Abstract The FDA's Cooperative Agreement Program for States and Territories to Implement  National Produce Safety Program PAR-21-174 Project Period 2021-2026 Date:4/20/2021 Project Summary: The Nevada Department of Agriculture will establish a produce safety education, outreach and inspection program that is geared at Nevada producers. This project will support collaboration and information sharing with FDA, other state, and local agencies to build a long-term program.

PI_NAMEs: KEENAN-GARREN, KAILEY  (contact)

PROGRAM_OFFICER_NAME: HOEHNA, SHANNON

PROJECT_TITLE: Path C The Nevada Department of  Agriculture(NDA) Cooperative Agreement Project for maintenance and administration of a FSMA PSR compliant Produce Food Safety Program


ORG_CITY: DOVER

ORG_NAME: DELAWARE STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: DE

PHR: PROJECT NARRATIVE The Delaware Department of Agriculture Produce Safety Rule, is applying for Path B, Funding Band 10 for the grant entitled Implementation of FDA’s Produce Safety Rule PAR-21-174, to continue the implementation of the produce safety program that encourages the safe production of fruits and vegetables and promote understanding and compliance with the FDA’s Produce Safety Rule in Delaware. The grant will continue our efforts to reduce the risks associated with covered produce related food borne illnesses, injuries, or death and ultimately protects the public’s health.

PI_NAMEs: MACK, JAMIE  (contact)

PROJECT_TITLE: Path B Implementation of the FDA Produce Safety Rule in Delaware


ORG_CITY: OLYMPIA

ORG_NAME: WA STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: WA

PHR: PROJECT NARRATVE Project Title: Implementation of a Nationally Consistent Produce Safety Program in Washington State Continued development of WSDA’s Produce Safety Program (PSP) will reduce public health risks for consumers of Washington produce across the nation and around the world. By utilizing both education and enforcement to promote understanding of and compliance with the Food & Drug Administration’s Produce Safety Rule, the PSP will encourage the safe growing, harvesting, packing, and holding of fruits and vegetables, significantly advance a national integrated food safety system, and effectively fulfill the requirements of the Food Safety Modernization Act.

PI_NAMEs: CASTRO, LUISA  (contact)

PROJECT_TITLE: Path C Implementation of a Nationally Consistent Produce Safety Program in Washington State


ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE Sepsis is a devastating illness resulting in immune dysfunction, multiple organ failure and death and it is the leading cause of morbidity and mortality in critical care units in hospitals. We are studying the function of A2A adenosine receptors, which are molecules found on the surface of immune cells, in regulating the course of sepsis. By elucidating how A2A adenosine receptors modulate immune and organ function during sepsis, we can utilize this information to develop new pharmacologic approaches targeting A2A adenosine receptors to treat patients suffering from sepsis.

PI_NAMEs: HASKO, GEORGE  (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: Abnormal Neutrophil;activated Protein C;Adaptive Immune System;Address;Adenosine;Adoptive Transfer;ADORA2A gene;ADORA3 gene;Agonist;antagonist;Apoptosis;arm;Bacteria;Binding;cecal ligation puncture;Cell surface;cell type;Cells;Cessation of life;Characteristics;Chemotaxis;chronic infection;Clinical;Clinical Trials;clinically relevant;comparison control;Coupled;Critical Care;Critical Illness;cytokine;Data;exhaustion;extracellular;FDA approved;Functional disorder;Gene Expression;Genetic;Goals;Growth;GTP-Binding Proteins;Helper-Inducer T-Lymphocyte;Hospitals;Human;Hypoxia;Immune;immune function;Immune response;Immune system;Immune System Diseases;immunoregulation;Immunosuppression;Individual;Infection;Inflammation;Ingestion;Innate Immune System;Ischemia;Life;Lipopolysaccharides;Macrophage;Mediating;Medicine;Metabolic stress;Metabolism;migration;Modeling;monocyte;Morbidity - disease rate;mortality;Multiple Organ Failure;Mus;neutrophil;Organ;Organ failure;organ injury;pathogen;Patients;Phagocytosis;pharmacologic;Phenotype;Plasma;Process;Production;Purinergic P1 Receptors;Purines;receptor;Regulation;Regulatory T-Lymphocyte;Respiratory Burst;Role;secondary infection;Sepsis;septic;septic patients;Signal Transduction;Signaling Molecule;Site;Surface;Syndrome;TNF gene;transcriptome sequencing;Trauma

PROJECT_TITLE: Neutrophil A2A receptors in sepsis

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative Unfortunately, current medical therapies for glaucoma do not lower intraocular pressure sufficiently in most patients to slow disease progression. The present project extends our examination of an elegant pressure- sensitive mechanism involving nitric oxide production that regulates aqueous humor outflow facility in the conventional outflow pathway, the chief determinant of intraocular pressure. Studies proposed here are geared toward identifying control mechanisms responsible for intraocular pressure homeostasis, which can be exploited therapeutically to better control intraocular pressure in glaucoma patients.

PI_NAMEs: OVERBY, DARRYL R;STAMER, W DANIEL (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Acute;Aqueous Humor;Blood-Aqueous Barrier;Cells;Chronic;Data;desensitization;Development;Disease Progression;Drainage procedure;Endothelial Cells;Endothelium;Extracellular Matrix;Eye;Feedback;Flushing;Functional disorder;Funding;Generations;Glaucoma;Health;Homeostasis;insight;kinase inhibitor;Knowledge;Legal patent;Mediating;Medical;Molecular;neuroprotection;NG-Nitroarginine Methyl Ester;Nitric Oxide;novel;Obstruction;Ocular Hypertension;ocular surface;Open-Angle Glaucoma;Outcome Study;Particulate;Particulate Matter;Pathology;Pathway interactions;Patients;Permeability;Pharmaceutical Preparations;Physiologic Intraocular Pressure;Physiologic pulse;Pigments;pressure;Primary Open Angle Glaucoma;Process;Production;Progress Reports;Relaxation;Research;Resistance;response;Rho-associated kinase;Role;shear stress;Signal Transduction;Signaling Molecule;Source;Stretching;Structure of sinus venosus of sclera;Study models;success;targeted treatment;Testing;Therapeutic;Time;Tissues;Trabecular meshwork structure;Vascular Endothelium

PROJECT_TITLE: eNOS-Dependent Mechanoregulation of Intraocular Pressure

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: LA JOLLA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: CYTOSCAPE: AN ECOSYSTEM FOR NETWORK GENOMICS NARRATIVE Support of Cytoscape as a U24 Community Resource will enable NIH investigators to maintain and magnify their ongoing successful efforts to apply molecular network knowledge to identify new pathways, biomarkers, drug targets and genetic variants underlying disease.

PI_NAMEs: IDEKER, TREY  (contact)

PROGRAM_OFFICER_NAME: GAO, JEAN XUEJING

PROJECT_TERMS: Academia;Address;Adoption;Algorithms;Architecture;Attention;big biomedical data;bioinformatics resource;Biological;Biological Markers;Biological Process;Biology;cancer genome;cancer genomics;catalyst;cloud based;Cloud Computing;Communities;Computer software;Data;Data Science;Data Set;Development;Disease;Drug Targeting;Ecosystem;Environment;Extramural Activities;Funding;Gene Expression;gene regulatory network;Generations;Genetic Heterogeneity;genetic variant;Genetic Variation;genome analysis;genome sequencing;genomic data;Genomic Data Commons;Genomics;Genotype-Tissue Expression Project;Grant;Human Genome;Industry;infancy;innovation;Internet;Investments;Knowledge;knowledge hub;knowledge network;large datasets;Maintenance;model development;Modeling;Molecular;multiple omics;Network-based;next generation;open source;Pathway Analysis;Pathway interactions;Phenotype;Positioning Attribute;Production;rare variant;Research;Research Personnel;Resources;Services;software infrastructure;System;The Cancer Genome Atlas;Time;tool;Training;Training Programs;tumor heterogeneity;United States National Institutes of Health;Untranslated RNA;Update;Variant;Visualization;Work

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: AMHERST

ORG_DEPT: PHARMACOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: PROJECT NARRATIVE These studies will, for the first time, provide a comprehensive circuit and temporal genomic profiling following opioid self-administration in rats. These studies will lead to a fundamental understanding of the transcriptional processes occurring in opioid abuse-vulnerable neuron subtypes. Our studies have the ability to provide a foundation for multiple avenues of research on the neuron subtype molecular adaptations that persist during abstinence and often result in relapse.

PI_NAMEs: AMENT, SETH ABRAMS;DIETZ, DAVID M (contact);LOBO, MARY KAY

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: Abstinence;Acute;addiction;Animal Model;Applications Grants;ATAC-seq;Back;Behavior;Behavioral;Biological Assay;Brain;BRAIN initiative;Cell Nucleus;cell type;Cells;Chromatin;chromatin immunoprecipitation;Clustered Regularly Interspaced Short Palindromic Repeats;combat;CRISPR interference;CRISPR-mediated transcriptional activation;Cues;Data;Data Collection;data modeling;Data Set;Dependence;Dependovirus;dopaminergic neuron;Dorsal;drug abstinence;Drug Addiction;drug craving;drug seeking behavior;Epidemic;Epigenetic Process;epigenome;epigenomics;falls;Foundations;Frequencies;Friends;Functional disorder;Funding;Gene Expression;gene network;gene regulatory network;Genes;Genetic;Genetic Transcription;genome-wide;genomic locus;genomic profiling;genomic tools;Genomics;Globus Pallidus;Goals;Habenula;Health;Heroin;Heroin Dependence;Hour;Individual;insight;Knowledge;Label;Lateral;Link;Medial;Mediating;Messenger RNA;Modeling;Molecular;molecular subtypes;multimodal data;multiple omics;nerve supply;network models;Neurobiology;Neurons;Neurosciences;novel;Nucleus Accumbens;Opiate Addiction;Opioid;opioid abuse;opioid use;opioid use disorder;Output;Overdose;Pharmaceutical Preparations;Process;prolonged abstinence;Proteins;psychostimulant;Rattus;Regulation;Relapse;Research;Research Personnel;Rewards;Role;Self Administration;Thalamic structure;Therapeutic;Time;Tissues;tool;Training;Transcription Process;transcriptome;transcriptome sequencing;transcriptomics;Ventral Tegmental Area;web portal

PROJECT_TITLE: Heroin-Induced genomic regulation of Ventral Pallidum neuron subtypes


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Cardiovascular;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE We have identified a novel function of angiotensin-converting enzyme in the brain, and found that inhibition of this enzyme has the potential to counteract the addictive properties of opioids. The goal of this proposal is to identify new compounds that can inhibit angiotensin-converting enzyme in the brain, and determine if these compounds hold promise as new treatments for opioid use disorders.

PI_NAMEs: MORE, SWATI S (contact);ROTHWELL, PATRICK

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: absorption;ACE2;Acute;addiction;Affect;Aminopeptidase;Angiotensin-Converting Enzyme Inhibitors;Angiotensins;Attenuated;Behavior;Behavior assessment;Biochemical Reaction;Biological Assay;Blood - brain barrier anatomy;blood pressure regulation;Brain;brain tissue;Captopril;cardiovascular effects;Cardiovascular Physiology;Cardiovascular system;Catalytic Domain;cell type;Cells;Chemicals;Clinic;Clinical;conditioned place preference;Data;Dependence;Dissociation;Dopamine Receptor;Dose;drug development;Drug Exposure;Drug Kinetics;endogenous opioids;Enkephalins;Enzyme Inhibition;Excretory function;experimental study;extracellular;FDA approved;Fentanyl;fentanyl self-administration;Food;Genetic;Glutamates;Goals;high throughput screening;Hydrolysis;Hypertension;hypertension control;Impairment;improved;In Vitro;in vivo;inhibitor;interest;Intravenous;Knockout Mice;Lead;Libraries;Liquid Chromatography;Long-Term Depression;Measurement;Measures;Metabolism;Methionine Enkephalin;Modernization;Molecular Profiling;Motor;mu opioid receptors;Mus;Mutation;N Domain;Neurons;novel;novel therapeutics;Nucleus Accumbens;Opioid;opioid use disorder;patch clamp;Pathway interactions;Peptidyl-Dipeptidase A;Peripheral;pharmacologic;pharmacophore;Physiological;Play;presynaptic;Presynaptic Terminals;prevent;Property;Proteins;Psychological reinforcement;Receptor Activation;Receptor Signaling;Recombinants;Research;response;Rewards;risk mitigation;Role;scaffold;Self Administration;side effect;Signal Transduction;Slice;small molecule;small molecule libraries;tandem mass spectrometry;Testing;Therapeutic;therapeutic target;Time;Tissues;Toxic effect;Transgenic Mice;Validation;virtual;voltage clamp

PROJECT_TITLE: Identification of small molecules that regulate endogenous opioid signaling by inhibiting angiotensin converting enzyme


ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE  Currently, not all families who want a circumcision for their newborn sons are able to obtain the procedure soon after birth, even though this is the safest time for a circumcision to be performed. The goal of this study will be to create and test a new, more efficient way to deliver newborn circumcision care. The public health impact of this study will be to provide a way for newborn circumcisions to be done for more families who want one, which will particularly benefit families of lower socioeconomic status.

PI_NAMEs: JOHNSON, EMILIE KATHERINE (contact)

PROGRAM_OFFICER_NAME: CHEW, EMILY

PROJECT_TITLE: Newborn Circumcision Care Redesign

STUDY_SECTION: HSVR

STUDY_SECTION_NAME: Healthcare Systems and Values Research[HSVR]


ORG_CITY: TRENTON

ORG_NAME: NEW JERSEY STATE DEPARTMENTR/AGRICULTURE

ORG_STATE: NJ

PHR: The New Jersey Department of Agriculture will continue to establish a proactive, multi state produce safety network through education and regulation with a focus on inventory verification, education to all covered growers, and regulatory visits for all covered farms. We will work with our sub award to offer resources to growers on produce safety related topics and begin using an online system for tracking and storing inspection information. We believe this combination of efforts will lead to successful implementation of the Produce Safety Rule.

PI_NAMEs: KELLER, JOHN A (contact)

PROJECT_TITLE: Path B New Jersey Department of Agriculture's Continued Implementation of the Produce Safety Rule


ORG_CITY: HARTFORD

ORG_STATE: CT

PHR: Project Narrative: The Continued Development and Implementation of the Connecticut Department of Agriculture Produce Safety Program Under Path C is designed to successfully continue the development and implementation of the Connecticut Department of Agriculture’s Produce Safety Program. The State of Connecticut is seeking to advance the effort for Connecticut to be apart of a nationally integrated food safety system through high quality consistent regulatory programs, education, and technical assistance for producers.

PI_NAMEs: NELSON, KATE  (contact)

PROJECT_TITLE: Path C The Continued Development and Implementation of the Connecticut Department of Agriculture Produce Safety Program Under Path C


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: NARRATIVE The type 1 secretion system (T1SS) widely exists in many Gram-negative bacterial pathogens and secretes a variety of toxins which contribute to their virulence. This interdisciplinary study exploits single particle cryo-electron microscopy (cryo-EM), biochemical and in vivo approaches to dissect the structures and mechanisms of the T1SS. The study will provide a new basis for developing future therapeutic interventions against a range of bacterial infections.

PI_NAMEs: MI, WEI  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Adaptor Signaling Protein;Adenylate Cyclase;ATP phosphohydrolase;ATP-Binding Cassette Transporters;Bacterial Adhesins;Bacterial Genome;Bacterial Infections;Binding;Biochemical;Bioinformatics;Biological Assay;Bordetella pertussis;C-terminal;Cells;Childhood;Complex;Cryoelectron Microscopy;Cytoplasm;Data;design;Electron Spin Resonance Spectroscopy;Environment;Exposure to;extracellular;Future;Glycine;Goals;Gram-Negative Bacteria;Hemolysin;Hydrolysis;Immune response;improved;In Vitro;in vitro Assay;in vivo;inhibitor;Interdisciplinary Study;Invaded;Ion Channel;Kingella kingae;Knowledge;Location;Membrane;Modeling;Molecular;Molecular Conformation;Movement;Mutation;Names;Nature;Nucleotides;particle;pathogen;pathogenic bacteria;Pathway interactions;periplasm;Pertussis;Play;polypeptide;prevent;Protein Secretion;Proteins;Reaction;Regulation;Research;Resolution;Role;Salmonella enterica;screening;Signal Transduction;Site;small molecule;Structural Models;Structure;System;Therapeutic Intervention;Tissues;Toxin;Transmembrane Domain;Uropathogenic E. coli;VDAC1 gene;Virulence

PROJECT_TITLE: Molecular Mechanisms of the Type I Secretion System from Bacterial Pathogens

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ORG_CITY: PHOENIX

ORG_NAME: ARIZONA STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: AZ

PHR: Arizona Project Narrative This Arizona Department of Agriculture (AZDA) project entitled Arizona Produce Safety Rule Implementation, is intended to facilitate long-term improvement to the national food safety system. The AZDA project intends to further the development of an integrated fresh produce food safety system in Arizona. This will be done through training/outreach and inspection/enforcement of the United States Food and Drug Administration (FDA) Food Safety Modernization Act (FSMA) Produce Safety Rule.

PI_NAMEs: LOPEZ, TERESSA M (contact)

PROJECT_TITLE: Path C AZDA- Produce Safety Rule Program


ORG_CITY: LANSING

ORG_NAME: MICHIGAN STATE DEPT OF AGRICULTURE

PHR: Project Narrative Project Title: Michigan Department of Agriculture and Rural Development Produce Safety Program Implementation and Maintenance Path C MDARD will continue to develop a regulatory program that is focused on quality and national consistency with a focus on prioritizing farm operations covered by the Produce Safety Rule. MDARD will develop all aspects of the produce safety program upon the belief that education, outreach and technical assistance are critical to ensuring adoption of Produce Safety Rule practices and driving high rates of compliance, ultimately ensuring safer produce for consumers.

PI_NAMEs: SLAWINSKI, TIM  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, ANDREA

PROJECT_TITLE: Path C Michigan Department of Agriculture and Rural Development Produce Safety Program Implementation and Maintenance


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

PHR: Posttraumatic stress disorder (PTSD) is a chronic, debilitating condition among Veterans. In addition to psychological consequences, PTSD may increase risk for numerous physical health conditions, including autoimmune disease. Prior evidence suggests an association between PTSD and autoimmune (AI) disease, but studies have not rigorously examined the prospective relationship between PTSD and development of AI disease. Research is needed to examine potential racial or ethnic disparities in the relationship between PTSD and AI disease, and explore potential risk or mitigating factors, such as PTSD treatment. This study will investigate longitudinal associations between PTSD and AI disease, providing more stronger inference with advanced epidemiological methods and identifying risk or mitigating factors that may exacerbate or offset the link between PTSD and AI disease in a large, diverse sample of US Veterans. Such evidence can inform our understanding of causal mechanisms and identify targets for treatment and prevention.

PI_NAMEs: NISHIMI, KRISTEN MARIE (contact)

PROJECT_TERMS: Accounting;Address;anti-depressive agents;Antibodies;Antiinflammatory Effect;Attenuated;Autoimmune;Autoimmune Diseases;Big Data Methods;Biological Process;Black race;career;Chronic;Chronic Disease;Clinical;Complex;Data;Data Science;Data Scientist;Databases;Demographic Factors;design;Development;Diagnosis;Disease;disorder risk;disorder subtype;Electronic Health Record;Epidemiologic Methods;Epidemiology;ethnic disparity;ethnic minority population;Ethnic Origin;Etiology;European;evidence base;experience;feature selection;Funding;Goals;Health;Health behavior;health disparity;health record;Healthcare Systems;high risk;Immune;Immune response;improved;Incidence;Individual;Inflammation;Inflammatory;Intervention;K-Series Research Career Programs;Knowledge;Lasso;Latinx;Link;Literature;Logistic Regressions;Machine Learning;machine learning algorithm;machine learning model;Measures;Mediating;Mental disorders;Mental Health;Mentors;Mentorship;Methods;military veteran;Modification;Nature;novel;Pathology;Patients;Pattern;Pharmaceutical Preparations;physical conditioning;Post-Traumatic Stress Disorders;Prevention;Process;prospective;protective factors;psychiatric comorbidity;Psychiatric Diagnosis;psychologic;Psychoneuroimmunology;Psychotherapy;Race;racial disparity;racial minority;random forest;Records;Research;Research Personnel;Risk;Risk Factors;risk mitigation;Sampling;San Francisco;Selective Serotonin Reuptake Inhibitor;Severities;sociodemographics;Structural Models;Testing;Time;Training;Trauma;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: PTSD and Autoimmune Disease: Towards Causal Effects, Risk Factors, and Mitigators


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Data Science

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Project Narrative The training program, “Research Training on Harnessing Data Science for Global Health Priorities in Africa” will build upon existing data science research and training capacity at partnering African and global institutions to enhance innovative new data science research capacity. Harvard University will lead the training collaboration with Heidelberg University in support of the University of KwaZulu-Natal (UKZN) as a hub with four spoke partners in sub-Saharan African countries, namely Ghana, Nigeria, Tanzania, and Uganda. Data science has the potential to generate new insights on the drivers of health and to boost healthcare delivery in Africa. The realization of this potential hinges on the availability of a large number of highly-trained data scientists in health domains on the continent. The training program will strengthen academic institutions in Africa to (a) establish robust capacity in health data science methods, and (b) ultimately advance research, application capacity, and health outcomes in identified global health priorities: (i) health systems strengthening, and (ii) food systems, climate change and planetary health.

PI_NAMEs: BARNIGHAUSEN, TILL ;FAWZI, WAFAIE W (contact);MOSHABELA, MOSA ;MWAMBI, HENRY GODWELL

PROGRAM_OFFICER_NAME: POVLICH, LAURA

PROJECT_TERMS: Address;Africa;African;climate change;Collaborations;Communities;Competence;Country;Data;data resource;Data Science;Degree program;design;digital;doctoral student;Educational Curriculum;Equilibrium;experience;Faculty;Fellowship;Food;Ghana;global health;Goals;Health;health data;Health Priorities;Health system;Individual;innovation;Institution;Instruction;Internships;Master of Science;Medical;Mentors;Methods;multidisciplinary;Nigeria;open data;Outcome;Participant;Policies;Postdoctoral Fellow;Principal Investigator;programs;Public Health;Research;Research Activity;Research Personnel;Research Project Grants;Research Training;Resources;Series;skills;South Africa;Structure;Students;symposium;System;Tanzania;Technology;Training;Training Activity;training opportunity;Training Programs;Uganda;Universities;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-C(70)]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Autoimmune Disease

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Autoimmunity and Immunopathology are very important basic and applied research areas that are leading the way in bringing the insights of basic immunology to the patient in the form of biological and mechanism-based therapies. Our AI/IP training program seeks to train the spectrum of basic to applied and predoctoral to postdoctoral clinical fellow young scientists to carry out the next generation of cutting edge research. The dynamic environment of the University of Pittsburgh School of Medicine is ideally suited to do so.

PI_NAMEs: SHLOMCHIK, MARK J (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TITLE: Autoimmunity and Immunopathology Training Program

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Infectious Diseases;Lung;Microbiome;Patient Safety;Pediatric;Pneumonia;Pneumonia and Influenza;Transplantation

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE  Aspiration pneumonias cause more than 25% of deaths in children with neurologic impairment, yet the pathophysiology of these pneumonias remains poorly understood. Using novel technologies to precisely phenotype the type and extent of esophageal and gastric dysmotility and a novel therapy, prucalopride, to improve this dysmotility, we will test our hypothesis that esophageal and gastric dysmotility are independent risk factors for developing aspiration pneumonia and that treatment of dysmotility will improve aspiration- associated respiratory symptoms. Our findings will critically advance the understanding of aspiration pneumonias’ pathophysiology beyond acid reflux and will yield a novel therapy to reduce disability, improve health outcomes, increase life expectancy, and reduce health care costs, in a medically vulnerable population.

PI_NAMEs: ROSEN, RACHEL L (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Acids;Address;Affect;Agonist;allograft rejection;aspirate;Aspiration Pneumonia;associated symptom;Bile fluid;Blinded;Bolus Infusion;Cessation of life;Chemicals;Child;Child health care;Chronic;Clinical;clinically significant;cost;Crossover Design;Development;Diagnosis;disability;Disease;Esophageal motility disorders;Esophagus;Evaluation;Event;experience;Frequencies;Functional disorder;gastric microbiome;Gastroesophageal reflux disease;gastrointestinal;Gastrostomy;Health;Health Care Costs;high risk population;hospital readmission;Hospitalization;Impairment;improved;improved outcome;Inflammatory;injured airway;innovation;Intensive Care;Intervention;Knowledge;Length of Stay;Life Expectancy;Link;Liquid substance;Literature;Longitudinal cohort study;Lung;lung allograft;lung development;Lung Diseases;Lung Transplantation;Measurable;Measures;medical vulnerability;microbial;microbial composition;microbiome;Modeling;mortality;Motility;motility disorder;Movement;Neurologic;new technology;novel;novel therapeutics;Obstruction;Omeprazole;Operative Surgical Procedures;Oropharyngeal;Outcome;Patients;Pattern;Pediatric Hospitals;Pepsin A;Phenotype;Pneumonia;Population;pressure;Proton Pump Inhibitors;Pulmonary aspiration of gastric contents;Pulmonary Inflammation;Randomized;Recommendation;Recurrence;Reflux;Research;Research Design;Research Personnel;Respiratory Signs and Symptoms;Retrospective Studies;Risk;Risk Factors;Severities;standard of care;Stomach;Symptoms;Technology;Testing;Therapeutic Intervention;Therapeutic Trials;Transplant Recipients;Tube;Upper digestive tract structure;Vulnerable Populations;Work

PROJECT_TITLE: The impact of upper gastrointestinal dysmotility on aspiration-associated aerodigestive disorders in children

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_DEPT: BIOLOGY

PHR: PROJECT NARRATIVE Cytokinesis is the process by which one cell becomes two and is foundational across the three domains of life; in metazoans, cytokinesis is accomplished by a contractile ring that forms around the cell equator and constricts to partition the cell contents. To ensure that each cell obtains a single copy of the genetic code, cytokinesis is orchestrated by the cellular machine that separates the replicated DNA; failure of this process is thought to contribute to the origin of ~40% of cancers. The goal of this project is to understand how cytokinesis is orchestrated in multicellular organisms with sufficient fidelity to preserve genome integrity and prevent the genesis of cancers.

PI_NAMEs: OEGEMA, KAREN F (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Actomyosin;Address;Anaphase;aurora kinase A;Biological Assay;C-terminal;Caenorhabditis elegans;CDC2 gene;Cell Cycle;Cell division;Cell membrane;Cells;Centrosome;chemotherapeutic agent;Chromosome Segregation;Chromosomes;Competence;Complement;Complex;constriction;Cyclin B;Cytokinesis;Cytoplasm;Data;daughter cell;Diffusion;Dimensions;dimer;DNA biosynthesis;Embryo;Failure;Family;Genetic Code;genome integrity;Genomics;Goals;GTPase-Activating Proteins;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Human;inhibitor;interest;Investments;Kinesin;Life;Malignant Neoplasms;Measures;Mediating;Mediator;Microtubule Bundle;Microtubules;Mitosis;Mitotic;Mitotic spindle;Modeling;Molecular;Monitor;Mothers;Mutation;N-terminal;Nuclear;Organism;Pattern;permissiveness;Phase;Phosphorylation;Phosphotransferases;PLK1 gene;Population;Positioning Attribute;preservation;prevent;Process;Proteasome Inhibition;Proteins;rho;Role;screening;Signal Transduction;Specific qualifier value;System;Tertiary Protein Structure;Testing;Time;TP53 gene;Up-Regulation;Work

PROJECT_TITLE: Mechanisms of Cytokinesis

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Antibiotic prophylaxis at the time of surgery is a critical component to reduce Surgical Site Infections (SSIs). Although explicit guidelines from the Surgical Care Improvement Project (SCIP) have near universal adherence, these guidelines do not encompass key components of antibiotic best practice as recommended by the Infectious Disease Society of America (IDSA). The present application examines the association of IDSA-nonadherence with SSIs in a nationwide sample and envisages the development and testing of an Electronic Health Record (EHR)-based intervention based on healthcare provider needs, to improve guideline adherent perioperative antibiotics prophylaxis and decrease rates of SSIs.

PI_NAMEs: BARDIA, AMIT  (contact)

PROGRAM_OFFICER_NAME: HENDERSON, SUSAN

PROJECT_TITLE: Targeting Surgical Site Infections through a Perioperative Antibiotic Clinical Decision Support Tool

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


NIH_SPENDING_CATS: Bioengineering;Rare Diseases

ORG_CITY: PORTLAND

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Narrative LC8 is a universal hub protein that binds to intrinsically disordered proteins (IDPs) leading to a unique class of multi-valent complexes - ladder-like in structure and `reversibly ordered' in that disassembly is intrinsic to their function and regulation. The dynamic structural properties of LC8-IDP assemblies are critical to the organization and regulation of diverse cellular systems, while aberrant LC8 function is associated with many diseases, including cancer, neurodegenerative diseases and rabies viral infection. Yet, LC8/IDP complexes remain poorly understood due to their complex structural properties, so we will deploy an innovative array of computational and experimental techniques to quantitatively characterize their heterogeneity and fluctuations/dynamics on multiple scales.

PI_NAMEs: BARBAR, ELISAR J;ZUCKERMAN, DANIEL M (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Address;Affinity;Amino Acid Sequence;Architecture;Binding;Binding Proteins;Biochemical;Biological;Biological Assay;Biological Process;Biophysics;Calorimetry;Cell Cycle;cell growth regulation;Cells;Collaborations;combinatorial;Comparative Study;Complex;Computer Models;Computing Methodologies;Cooperative Behavior;crosslink;Custom;Data;Disease;Dynein ATPase;Ebola;Electron Microscopy;Elements;Event;Exhibits;experience;experimental study;flexibility;Formulation;frontier;Gene Expression Regulation;Geometry;Heterogeneity;innovation;Kinetics;Length;Ligands;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Methods;Mitotic spindle;Modeling;Molecular;Molecular Conformation;molecular dynamics;molecular imaging;Molecular Motors;Motor;Negative Staining;Nerve Degeneration;Neurodegenerative Disorders;novel;Nuclear Magnetic Resonance;Nuclear Pore;Pathway interactions;Phase;Play;Population;Positioning Attribute;Prevalence;Process;Property;protein complex;protein crosslink;Proteins;Rabies;recruit;Regulation;Regulatory Element;Resolution;Role;scaffold;sensor;simulation;single molecule;structural biology;Structure;success;Surface Plasmon Resonance;Syndrome;System;Techniques;Technology;Theoretical model;theories;Thermodynamics;Titrations;Transcriptional Regulation;Validation;Variant;Viral Proteins;Virus Diseases;Work

PROJECT_TITLE: Multiscale Characterization of a Unique Class of Duplex, Multivalent IDP systems

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Lung;Pediatric;Social Determinants of Health

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: Narrative Disease of the heart, lungs and blood are associated with substantial morbidity and mortality in pediatric populations. The Nationwide Children’s Hospital Research Experiences in Childhood Heart, Lung and Blood Sciences (REaCH-LABS) is designed to provide meaningful summer opportunities for undergraduate students from backgrounds underrepresented in medicine in scientific areas of interest to NHLBI. Through a novel partnership with the Student National Medical Association, we will recruit, train, and support the next generation of diverse biomedical researchers.

PI_NAMEs: CHISOLM, DEENA  (contact);GARG, VIDU

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: Admission activity;Adult;African American;Age;Area;Biomedical Research;Blood;Budgets;career;Cause of Death;Child;Child health equity;Childhood;Chronic;Clinical;cohort;Congenital Abnormality;demographics;design;Development;Discipline of Nursing;Ecosystem;Educational Curriculum;Educational workshop;Eligibility Determination;Ethnic Origin;experience;Exposure to;Faculty;follow-up;Funding;graduate school;graduate student;Growth;Health;health disparity;health equity promotion;Health Sciences;Heart;Heart Diseases;Hematological Disease;high school;Infant;interest;Internships;Interview;Leadership;Lung;Lung Diseases;Measures;Medical;medical schools;Medical Students;Medicine;meetings;member;Mentors;Mentorship;Minority;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;neonate;next generation;novel;Ohio;Organizational Affiliation;Outcome;Participant;Patient Recruitments;Pediatric Hospitals;Pediatric Research;peer;peer coaching;Population;Population Scientist Supplement (R25);Postbaccalaureate;Postdoctoral Fellow;Process;programs;Publications;Qualifying;Race;Readiness;recruit;Research;Research Personnel;Research Priority;Research Project Grants;Respiratory Disease;Respiratory Tract Infections;role model;Science;skills;socioeconomics;STEM career;Structure;student participation;Students;success;summer research;Training;undergraduate student;Underrepresented Students;United States National Institutes of Health;Universities;Youth

PROJECT_TITLE: Research Experiences in Childhood Heart, Lung, and Blood Science - REaCH LABS


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE  We propose a 5-year, intensive mentored WRHR Scholar Program at UCSF to develop independent research careers for obstetrician/gynecologists in clinical, translational and basic science women's health research. Such training and career development, embedded in an environment of collaboration and interaction among mentors and Scholars, is a powerful approach to creating the next generation of researchers who will translate the findings from the laboratory and clinic for the betterment of women's health. The overarching goal of our WRHR program is to enhance the pipeline women's health researchers.

PI_NAMEs: JACKSON, ANDREA VASHTI (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, STEVEN

PROJECT_TERMS: California;career;career development;Clinical;Clinical Research;cohort;Collaborations;Coupled;Discipline;Discipline of obstetrics;Disease;Environment;ethnic minority population;experience;Faculty;Funding;Gynecology;Health Promotion;improved;Institution;Laboratories;Learning;Link;Medicine;Mentors;Mentorship;Mission;next generation;Pathway interactions;prevent;Productivity;programs;racial minority;recruit;Reproductive Health;Reproductive Sciences;Research;research faculty;Research Methodology;Research Personnel;Resources;San Francisco;Science;Scientific Advances and Accomplishments;skills;success;Training;Universities;Woman;Women's Health;women's reproductive health

PROJECT_TITLE: Women's Reproductive Health Research


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Dissemination and Implementation Research;Mental Health;Prevention

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE The University of Pennsylvania Training Program in Implementation Science and Mental Health is the only NIMH- funded T32 program in the United States that provides training exclusively in implementation science and mental health. Our trainees have developed successful careers applying methods from implementation science to improve mental health services in schools, specialty mental health, primary care, and juvenile justice. We will continue to provide training to postdoctoral trainees and request additional slots for predoctoral trainees. Successful trainees will continue to be leaders in advancing our understanding of the best ways to improve mental health through broad-scale implementation of EBPs in a variety of settings, in line with the fourth objective of the National Institute of Mental Health's (NIMH) strategic plan. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

PI_NAMEs: MANDELL, DAVID S (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Communities;experience;Fellowship;implementation science;Mental health promotion;post-doctoral training

PROJECT_TITLE: The academic-community experience (ACE): A postdoctoral training fellowship in implementation science to promote mental health


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Obesity

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Angiogenesis is a key pathogenic component of obesity and at least 70 known diseases, and it is primarily driven by the vascular endothelial growth factor receptor (VEGFR) and its family of VEGF ligands. However, targeting VEGF alone has not achieved the promise of stable vascular control, so new approaches are needed to control and direct vascular development. The purpose of these studies is to biologically and computationally assess how the new theory of cross- family signaling may control vascular signaling at the molecular, protein, and cellular levels.

PI_NAMEs: IMOUKHUEDE, PRINCESS IZEVBUA (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Adaptor Signaling Protein;Adipocytes;Adipose tissue;Affinity;Amino Acids;angiogenesis;Area;Binding;Blood Vessels;Categories;Cell Physiology;Cell Proliferation;Cell Survival;Cells;Computer Models;Data;design;Development;Directed Molecular Evolution;Disease;Disease Progression;Dose;Effector Cell;Endothelial Cells;Endothelial Growth Factors Receptor;Endothelium;Engineering;experimental analysis;Family;Fibrinogen;Fibroblasts;Fibrosis;Goals;Growth Factor;Growth Factor Inhibition;Growth Factor Receptors;Health;Human;in silico;In Vitro;Inflammation;innovation;Insulin Resistance;KDR gene;kinetic model;Knowledge;Lead;Libraries;Ligands;Lipids;Malignant Neoplasms;Measurement;Measures;Mediating;Medicine;member;migration;Modeling;Molecular;molecular dynamics;mutation screening;National Heart, Lung, and Blood Institute;novel;novel strategies;Obesity;obesity treatment;obesogenic;Organoids;Pathogenicity;pedagogy;Permeability;Phosphorylation;Platelet Activating Factor;Platelet-Derived Growth Factor;Platelet-Derived Growth Factor Receptor;pre-clinical;Pre-Clinical Model;Predictive Factor;Process;Proliferating;Property;protein structure;Proteins;PTK2 gene;receptor;Receptor Activation;receptor binding;Regulation;Research;response;Role;Scheme;screening;Signal Transduction;simulation;Site;Structure;System;Systems Biology;Testing;text searching;theories;Therapeutic;Thymidine Phosphorylase;Tissue Expansion;Tissues;Translating;Tyrosine;Validation;Vascular Diseases;Vascular Endothelial Growth Factors;Vascularization;Work

PROJECT_TITLE: Measurement and Prediction of Endothelial Cross-family Signaling

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ORG_CITY: CLEVELAND

ORG_DEPT: PATHOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Project Narrative The Immunology Training Program Leadership Track provides PhD training focused upon producing future group leaders in academic and industrial (pharmaceutical and biotechnology) settings who will drive important biomedical research efforts in immunology and immunology-related areas of clinical and basic science importance. This includes traditional topics such as infectious disease, vaccine development, organ transplantation, and autoimmunity, but extends to cutting-edge and rapidly developing subfields such as systems immunology and glycoimmunology.

PI_NAMEs: COBB, BRIAN A (contact)

PROJECT_TITLE: Immunology Training Program-Predoctoral

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ORG_CITY: JEFFERSON CITY

ORG_NAME: MISSOURI STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: MO

PHR: Missouri Department of Agriculture The FDA's Cooperative Agreement Program for States and Territories to Implement a National  Produce Safety Program PAR-21-174  Project Period: 2021-2026 Project Narrative During the four years the Missouri Department of Agriculture participated in the first Produce Safety Cooperative Agreement, we have seen much progress as a result of building strong working relationships with sub-awardees, sister agencies, auctions, produce brokers, and growers. Our thorough outreach has included many Produce Safety Alliance grower trainings, technical assistance, brochures, and helpful promotional items like clipboards, buckets, and templates for keeping records. The initial inspections for Large and Small growers went well and we are looking forward to continuing to build our compliance program in an effort to protect consumers and support growers.

PI_NAMEs: HAWCROFT, BART  (contact)

PROJECT_TITLE: Path B Missouri's Produce Safety Program


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS STATE DEPARTMENT OF AGRICULTURAL RESOURCES

PHR: MASSACHUSETTS DEPARTMENT OF AGRICULTURAL RESOURCES Submission in Response to the Funding Opportunity Announcement (FOA) for PAR-21-174 April 5, 2021 Revision 1.0 Project Narrative In response to the FOA for PAR-21-174, MDAR’s Produce Safety Inspection Program, will select and implement PATH C, as indicated in the FOA for PAR-21-174. MDAR’s PSIP will conduct produce safety inspections under authority established under M.G.L Chapter 128, section 124, adopting 21 CFR Part 112 in its entirety, and through regulations promulgated under 330 CMR 34:00

PI_NAMEs: BOTELHO, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: FREDRICK, JEANETTE

PROJECT_TITLE: Path C The Maintenance & Expansion of the Produce Safety Program in Massachusetts


ORG_CITY: DES MOINES

ORG_NAME: IOWA DEPT AGRICULTURE/LAND STEWARDSHIP

ORG_STATE: IA

PHR: Iowa (IA) Path A PAR-21-174 Program Narrative The State of Iowa Program will follow the Program Path A with a focus on Program Objectives 1, 2, 3, and 4 as outlined in the funding opportunity PAR-21-174. The state program mission is to strengthen and enhance the existing structures in place that establish knowledge and adherence to the FDA Standards for the Growing, Harvesting, Packing, and Holding of Produce for Human Consumption, otherwise known as the Produce Safety Rule under 21 CFR Part112.

PI_NAMEs: KRZTON-PRESSON, JOHN  (contact)

PROJECT_TITLE: Path A - Advancing Iowa's Efforts in Continuing to Attain High Rates of Compliance with the FDA's Produce Safety Rule through Education, Outreach & Technical Assistance to Iowa Growers


ORG_CITY: REYNOLDSBURG

ORG_NAME: OHIO STATE DEPARTMENT OF AGRICULTURE

PHR: Ohio- Project Narrative The Ohio Department of Agriculture’s development and implementation of a produce safety program is a part of a national effort to advance a national integrated food safety system (IFSS). Funding of this application help promote an IFSS and it will allow Ohio to share program information such as inventory, with the FDA.

PI_NAMEs: TAYLOR, JODI  (contact)

PROJECT_TITLE: Path C Ohio's Plan to Implement a National Produce Safety Program


ORG_CITY: AUSTIN

ORG_NAME: TEXAS STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: TX

PHR: Project Narrative Project Title: Cooperative Agreement to Implement a National Produce Safety Program in Texas Project Narrative: The Texas Department of Agriculture (TDA) will continue to work with the FDA through the cooperative agreement to inform and educate growers on the safe production of fresh fruits and vegetables and ensure regulatory compliance meant to hold growers accountable to the minimum expectations established by the Produce Safety Rule (PSR). Created within the Trade and Business Development Division, TDA’s Office of Produce Safety (TOPS) continues to establish, design, and implement educational programs to minimize the adverse effects of produce contamination focusing on prevention and has developed a regulatory program to hold growers accountable to the minimum requirements of FSMA, specifically the PSR, in the form of an on-farm assessment and compliance and enforcement initiatives.

PI_NAMEs: DE LOS SANTOS, RICHARD  (contact)

PROGRAM_OFFICER_NAME: VARGO, ADRIANNA

PROJECT_TITLE: Path C Texas Produce Safety Multi-Year Strategic Plan


ORG_CITY: MADISON

ORG_NAME: WISCONSIN DEPT/AGRI/TRADE/CONSUM/ PROT

PHR: Project Narrative The Wisconsin Department of Agriculture, Trade and Consumer Protection’s project entitled “The FDA’s Cooperative Agreement Program for States and Territories to Implement a National Produce Safety Program” is intended to continue implementation of a Produce Safety Regulatory Program that encourages the production of safe fresh fruits and vegetables and compliance with the requirements of FDA’s regulation “Standards for the Growing, Harvesting, Packing, and Holding of Produce for Human Consumption” (commonly referred to as the Produce Safety Rule). Improving produce safety will protect public health by reducing the incidence of foodborne illness resulting from the consumption of produce contaminated with disease-causing microorganisms. The expected outcome of this work is a highly integrated Wisconsin Produce Safety Regulatory Program that educates produce businesses in best practices for minimizing the contamination of fresh fruits and vegetables with pathogenic microorganisms, and verifies that these practices are followed. Funding Opportunity Announcement (FOA) Number: PAR-21-174 - Path B Jul 1, 2021 – Jun 30, 2026

PI_NAMEs: SPRECKER, TROY S (contact)

PROJECT_TITLE: Path B Produce Safety Cooperative Agreement Program 2021-2026


ORG_CITY: RICHMOND

ORG_NAME: VA ST DEPT/ AGRICULTURE & CONSUMER SRVS

ORG_STATE: VA

PHR: PROJECT NARRATIVE The Virginia Department of Agriculture and Consumer Services (VDACS) project entitled Maintaining the Produce Safety Program at VDACS under Path C to Enhance Produce Safety and Achieve High Rates of Compliance with the FDA’s Produce Safety Rule is intended to enhance and maintain the current produce safety regulatory program in Virginia to address the growing, packing, holding and dissemination of produce grown on farms and achieve high rates of compliance with the FDA’s Produce Safety Rule. The VDACS Produce Safety Program will utilize federal funding to enhance or establish the following program objectives as identified in the cooperative agreement: • Objective 1 – Program Documentation: Create an Assessment document that will provide  complete jurisdictional information related to each item under Produce Landscape, Produce  Program Resources, and Produce-Related Response. Create a Project Plan that will document  plans, progress, accomplishments, and setbacks in achieving each program objective. • Objective 2 – Program Administration: Establish the foundational resources, including, but not  limited to, personnel, supplies, training, authority, and agreements, needed to fulfill the project plan. • Objective 3 – Education, Outreach and Technical Assistance: Provide opportunities for education,  outreach, and technical assistance on the Produce Safety Rule and Virginia’s produce regulatory  program to produce farms, prioritizing covered farms. • Objective 4 – Farm Inventory: Establish a complete and accurate inventory of produce farms, that  captures at least the minimum required data elements, which can be used to implement  corresponding objectives. • Objective 5 – Inspection Program: Conduct produce safety rule inspections that focus on quality  and national consistency. Establish an annual inspection work plan that utilizes inspection  frequency and risk-based prioritization. • Objective 6 – Compliance and Enforcement Program: Establish a compliance and enforcement  regulatory program focused on quality and national consistency that utilizes compliance and  enforcement action(s) that will result in the greatest protection of public health. • Objective 7 – Produce Related Event Response Planning and Implementation: Fully integrate with  the Virginia Rapid Response Team to identify, coordinate, and implement produce related  response activities that benefit public health outcomes. Develop specific mechanisms to  coordinate with other local, state, territory, and federal agencies for produce safety activities  where gaps may currently exist. Together, these seven objectives will further enhance the current produce safety regulatory program in Virginia so that high rates of compliance with the FDA’s Produce Safety Rule will be achieved. Additionally, they will encourage the safe production of fruits and vegetables, promote understanding and minimize the risk of serious adverse health consequences or death from consumption of contaminated Virginia grown produce as well as to ensure the further integration into a Nationally Integrated Food Safety System (IFSS). It is anticipated that through education and training along with enforcement and compliance of the FDA Produce Safety Rule, there will be less foodborne illness outbreaks nationwide traced back to raw produce grown in the Commonwealth of Virginia and less illnesses and deaths of Virginia residents consuming locally grown produce. Future federal funding and the actuality of FSMA are essential to the existence of the VDACS Produce Safety Program.

PI_NAMEs: BUNGO, ERIK ASHLEY (contact)

PROJECT_TITLE: Path C Maintaining the Produce Safety Program at VDACS under Path C to Enhance Produce Safety and Achieve High Rates of Compliance with the FDA's Produce Safety Rule.


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision

ORG_CITY: HOUSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: PROJECT NARRATIVE  The goal of this project is to develop a new instrument that will enable direct non-invasive measurements of the mechanical properties of the lens of the eye in the clinic. The instrument will facilitate the development of new procedures that rely on lens softening to treat presbyopia, the progressive age-related loss of our ability to focus on near objects. It will also be used in studies designed to understand how age-related changes in the mechanical properties of the lens contribute to presbyopia.

PI_NAMEs: LARIN, KIRILL V (contact);MANNS, FABRICE ;SCARCELLI, GIULIANO

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Age;age related;age related changes;Anatomy;Animals;biomechanical model;Biomechanics;Biometry;Calibration;Clinic;Clinical;Coupling;Crystalline Lens;Data;design;Development;Devices;efficacy evaluation;Elasticity;elastography;Eye;functional outcomes;Goals;Human;human subject;image guided;Imaging Device;in vivo;instrument;instrumentation;Knowledge;lens;Lens development;lens induction;Measurable;Measurement;Measures;mechanical properties;Mechanics;Methods;Microscopy;Modality;Monitor;multidisciplinary;multimodality;new technology;novel;Optical Coherence Tomography;Optics;Oryctolagus cuniculus;Outcome;Outcome Assessment;Physiology;Preclinical Testing;Presbyopia;preservation;Procedures;Quality of life;research clinical testing;Research Design;Retreatment;Role;Specific qualifier value;Spectrum Analysis;Stress;Stretching;Surface;System;Techniques;Technology;Testing;Therapeutic procedure;Time;Tissues;treatment effect;treatment optimization;Treatment outcome;Validation;Vision

PROJECT_TITLE: Biomechanics of accommodation


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

PHR: Project Narrative The emergence and spread of Clostridioides (Clostridium) difficile in hospitals and nursing homes presents a large and urgent threat to human health. We will utilize multiple approaches to understand the cell envelope stress response systems in C. difficile responsible for resistance to cell wall targeting antibiotics daptomycin and vancomycin. These studies are relevant to public health because a greater understanding of how C. difficile responds to antibiotics like daptomycin and vancomycin may lead to identification of novel therapeutic targets.

PI_NAMEs: ELLERMEIER, CRAIG D (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Anabolism;Antibiotic Resistance;Antibiotics;Bacillus subtilis;Binding;Biogenesis;Bioinformatics;biological adaptation to stress;Categories;cell envelope;Cell membrane;Cell Wall;Cells;Cessation of life;Charge;Clostridium;Clostridium difficile;CRISPR interference;crosslink;Cysteine;Daptomycin;Data;Development;Essential Genes;experimental study;Extracellular Domain;follow-up;Foundations;gain of function;Genes;genetic approach;Glucosamine;Glycolipids;Glycopeptide Antibiotics;Goals;Health;Hospitals;Human;Immune system;Immunologic Factors;Individual;Infection;insight;knock-down;Lipids;loss of function;Mediating;member;Membrane;membrane biogenesis;Methods;Metronidazole;Modeling;mutant;new therapeutic target;novel;novel therapeutics;Nursing Homes;Operon;overexpression;Penicillin-Binding Proteins;Peptidoglycan;Peptidyltransferase;Persons;Pharmaceutical Preparations;Phase III Clinical Trials;Phenotype;Phosphatidylglycerols;Play;Polysaccharides;Production;programs;Proteins;Public Health;Publishing;Regulon;Reporter;Resistance;resistance gene;resistance mechanism;response;Role;Signal Transduction;Stress;Structure;System;Testing;tool;transcriptome sequencing;transposon sequencing;United States;Vancomycin

PROJECT_TITLE: Identification of daptomycin resistance mechanisms in Clostridioides difficile

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Pain Research;Prevention;Rehabilitation

ORG_CITY: SALT LAKE CITY

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Individuals with a leg amputation are particularly vulnerable to secondary complications, such as pain in the residual limb or tissue damage on the contralateral intact leg – all of which significantly degrades mobility and quality of life. These secondary complications are especially concerning for individuals with diabetes who have impaired vascular function to regulate tissue temperature, a known indicator of tissue health. Our proposal will uncover the mechanisms of tissue thermoregulation, integrating biomechanical and vascular physiology analyses to understand the factors that contribute to tissue complications in individuals living with an amputation.

PI_NAMEs: TAKAHASHI, KOTA  (contact)

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: absorption;Acute;Adult;Affect;Amputation;Anatomy;Area;Attenuated;Automobile Driving;Benchmarking;Biomechanics;Blood Vessels;Circulation;comorbidity;Contralateral;decubitus ulcer;Devices;Diabetes Mellitus;Doppler Ultrasound;Early Diagnosis;effectiveness evaluation;Exposure to;femoral artery;foot;Force of Gravity;Health;Health protection;high risk;High temperature of physical object;Image;Impairment;improved;Individual;Intervention;Knee;Knowledge;Leg;Link;Mechanics;Microcirculation;Near-Infrared Spectroscopy;Oxygen;Pain;Pain in lower limb;Pattern;Physiologic Thermoregulation;Physiology;Prosthesis;prosthesis wearer;prosthetic socket;Protocols documentation;Quality of life;Radial;Regulation;residual limb;Residual state;response;Risk;risk mitigation;Risk Reduction;Role;Secondary to;Shock;Site;Skin Temperature;soft tissue;Source;Surface;Temperature;Tissues;Walking;Weight-Bearing state;Work

PROJECT_TITLE: Thermoregulation in individuals with a leg amputation: mechanics and vascular physiology factors to understand risks for tissue complications

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Genetics

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Project Narrative Amplification of MDM2 is a frequent mechanism by which cancer cells undermine p53 tumor suppressor activity. In this application we propose to carry our genome wide functional screens to identify the vulnerabilities in MDM2 overexpressing cancer cells. Identified factors will be validated by in vitro and in vivo experiments and tested as potential therapeutic targets in MDM2 amplified tumors.

PI_NAMEs: PANT, VINOD  (contact)

PROGRAM_OFFICER_NAME: CERO, CHERYL

PROJECT_TERMS: anti-cancer research;attenuation;Biochemistry;cancer cell;cell growth;Cells;CRISPR/Cas technology;Developmental Biology;Doctor of Philosophy;experience;experimental study;Funding;Genetic Screening;genome-wide;Human;In Vitro;in vivo;inhibitor;Journals;Laboratories;liposarcoma;Malignant Neoplasms;MDM2 gene;Molecular Biology;mouse genetics;Mus;Mutation;Normal Cell;overexpression;Pathway interactions;Production;professor;programs;Publishing;Regulation;Request for Applications;Research;Research Support;Role;Testing;therapeutic target;TP53 gene;treatment strategy;tumor;Tumor Suppression;Wages;Work

PROJECT_TITLE: Identifying the vulnerabilities in Mdm2 overexpressing cancer cells


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Infectious Diseases;Machine Learning and Artificial Intelligence

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative Conventional technology for intracellular imaging of viral proteins is limited in spatial and temporal resolution. This project will generate next-generation genetically encoded probe proteins that allow scientists to image when a given segment of a viral protein emerges from the ribosome, and observe when that segment moves or is buried during viral protein assembly. These tags will be used to image previously inaccessible processes, including viral polyprotein translation and homo-oligomerization of viral capsid proteins.

PI_NAMEs: SNOW, CHRISTOPHER DAVIS (contact)

PROGRAM_OFFICER_NAME: BROWN, LILIANA L

PROJECT_TERMS: Acceleration;Address;Affinity;Alpha Virus;Antibodies;antibody mimetics;Binding;Biochemistry;Biogenesis;Biological Process;Biology;Capsid;Capsid Proteins;Cells;Chimera organism;Chimeric Proteins;Color;Communities;Complex;Computers;Consumption;cost;Darkness;Data;design;Development;Directed Molecular Evolution;Engineering;Ensure;Epitopes;Eukaryotic Cell;experimental study;Flavivirus;Genetic Materials;Genetic Recombination;Genome;Hand;HIV-1;Homo;Hypersensitivity;Image;Imaging Device;Imaging technology;Immunoglobulin Fragments;in vivo;in vivo imaging;Infection;innovation;Investigation;Kinetics;Label;Lead;Libraries;Life;Life Cycle Stages;Light;live cell imaging;live cell microscopy;Machine Learning;Mechanics;Membrane;Methods;Microscopy;Modeling;Molecular;Molecular Biology;molecular dynamics;molecular imaging;Molecular Virology;Monitor;multiplexed imaging;next generation;non-invasive imaging;novel;particle;Peptides;Photobleaching;Polyproteins;Positioning Attribute;prediction algorithm;Predisposition;Process;Protein Dynamics;Protein Engineering;Protein Fragment;protein structure;protein structure prediction;Proteins;rational design;Reagent;real-time images;Recombinant Proteins;Refractory;Replication-Associated Process;Research;Research Personnel;Ribosomes;scaffold;Scientist;Signal Transduction;single molecule;spatiotemporal;Specificity;success;Technology;temporal measurement;Testing;Time;Translations;Validation;Variant;Viral;Viral Proteins;virology;Virus;Virus Diseases;Virus Replication;Visualization

PROJECT_TITLE: Multiplexed imaging of viral protein processing and assembly in live cells

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Childhood Obesity;Clinical Research;Diabetes;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE Infants born preterm are at increased risk of developing obesity and cardiometabolic disease compared with those born full term. The perinatal environment, such as exposure to maternal obesity and gestational diabetes, may further increase the risk of growth and cardiometabolic abnormalities in preterm infants. In this study, we will examine how maternal obesity and gestational diabetes influence the early development of fat tissue and subsequent growth and cardiometabolic abnormalities in early childhood in preterm infants.

PI_NAMEs: BUCK, CATHERINE O (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: 2 year old;Acceleration;adiponectin;Adipose tissue;Adolescence;Adult;Affect;Age;Biological Markers;Biometry;Biostatistical Methods;Birth;Blood Pressure;Body Composition;Body fat;Body mass index;candidate marker;Cardiometabolic Disease;cardiometabolism;career development;Child;Childhood;Clinical Research;Clinical Trials;cost estimate;critical period;Data;Development;Development Plans;Diabetes Mellitus;Dietary Intervention;early childhood;early detection biomarkers;Endocrinology;Energy Metabolism;epidemiology study;Exposure to;Fatty acid glycerol esters;Future;Gestational Age;Gestational Diabetes;Goals;Growth;Growth and Development function;High birth weight infant;high risk population;hormone metabolism;Hospitalization;Hospitals;Infant;infant nutrition;insulin sensitivity;Intervention;Lead;Leptin;Life;Longitudinal Studies;Magnetic Resonance Imaging;maternal diabetes;maternal obesity;Mentors;Metabolic syndrome;Metabolism;Monitor;Mothers;newborn adiposity;Newborn Infant;non-diabetic;Nutritional;Obesity;obesity development;obesity in children;obesity prevention;obesity risk;offspring;Pattern;Perinatal;perinatal environment;Perinatal Epidemiology;Perinatal Exposure;perinatal period;Pharmacotherapy;Phenotype;postnatal;Pregnancy;Premature Birth;Premature Infant;prepregnancy;prevent;prospective;Prospective cohort;public health relevance;Race;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Risk;risk stratification;Role;sex;Skinfold Thickness;sociodemographic factors;subcutaneous;therapy development;Tissues;Training;United States;Visceral;Vulnerable Populations;Weight;Weight Gain;Woman

PROJECT_TITLE: Preventing Obesity in Preterm Infants

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]