PI_NAMEs: GLEGHORN, JASON PAUL (contact)

PROJECT_TERMS: 3-Dimensional;Adopted;Air;Animal Model;Apical;Bacteria;Bacterial Infections;Biological Assay;Biological Models;Biomimetics;Bioreactors;Blood Vessels;Caring;Cell Compartmentation;cell type;Cells;Cervical;cervicovaginal;Cervix Mucus;Cervix Uteri;Chlamydia trachomatis;Clinical Research;Collagen;Communities;Complex;Data;Delaware;Democracy;design;Devices;Endocrine;Endothelial Cells;Environment;Epithelial Cells;Epithelium;Equipment;experience;Extracellular Matrix;fabrication;Family;Fibroblasts;Gel;Goals;Growth;Hormonal;Hormones;host microbiota;Human;Hydrogels;imaging capabilities;Immune;immune cell infiltrate;Immune response;Immunity;In Vitro;in vitro Model;in vivo;Individual;Infection;Infection Control;Infection prevention;Instruction;interstitial;interstitial cell;Lactic acid;Lactobacillus;Learning;Liquid substance;Membrane;Menstrual cycle;Methods;microbial;microbiome;microbiota;microphysiology system;Modeling;Mucous body substance;Neisseria gonorrhoeae;Organ;Organ Model;pathogen;pathogenic bacteria;Pathogenicity;Perfusion;Phenotype;Physiological;Physiology;Pregnancy;Production;programs;Proteins;reconstitution;Recording of previous events;response;Role;Rotation;Sexually Transmitted Diseases;Site;Standard Model;Structure;Surface;System;Techniques;Technology Transfer;Tissues;Training;Universities;Vagina;vaginal microbiome;Vascular Endothelium;web site

PROJECT_TITLE: Biomimetic Models Core


ADMINISTERING_IC: AA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Congenital Structural Anomalies;Contraception/Reproduction;Fetal Alcohol Spectrum Disorders (FASD);Genetics;Intellectual and Developmental Disabilities (IDD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

ORG_CITY: COLLEGE STATION

ORG_COUNTRY: UNITED STATES

ORG_DEPT: VETERINARY SCIENCES

ORG_FIPS: US

ORG_NAME: TEXAS A&M UNIVERSITY

ORG_STATE: TX

PHR: Project Narrative In the United States, seventy percent of all males report the consumption of alcohol, while forty percent drink at a binge level. While fetal alcohol spectrum disorder is undoubtedly linked to maternal alcohol consumption, emerging evidence suggests a significant male contribution to this debilitating condition. This proposal responds to `PA-18-507 - Effects of In Utero Alcohol Exposure on Adult Health and Disease' and will define the basic fundamental mechanisms by which male preconception exposure to alcohol impacts the developmental program of the fetus and contributes to the incidence of birth defects.

PI_NAMEs: GOLDING, MICHAEL C. (contact)

PROGRAM_OFFICER_NAME: DUNTY, JR, WILLIAM

PROJECT_TERMS: Adult;Alcohol consumption;alcohol effect;alcohol exposure;Alcoholic beverage heavy drinker;Alcohols;Animals;behavioral outcome;Biological;Birth;Child;Child Behavior;Child Development;Child Health;Chronic;Clinical Research;Conceptions;Congenital Abnormality;Counseling;Data;Defect;design;Development;developmental disease;developmental toxicology;Disease;drinking;Drug abuse;Drug usage;Education;Elements;Environmental Exposure;Epidemiology;Epigenetic Process;Exposure to;Fathers;fetal;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fetal Alcohol Syndrome;Fetal Development;Fetus;Future;Genetic Code;Government;Growth;Growth Disorders;Health;Heritability;Incidence;Inherited;Injections;Knowledge;Length;Life Style;Link;Long-Term Effects;male;maternal alcohol use;men;Metabolic;Modeling;Molecular;mouse model;Neurocognitive;novel;offspring;Parents;Paternal Exposure;Patients;Pattern;Performance;Phenotype;Physicians;Placenta;Play;Population;postnatal;Pregnancy;prenatal;problem drinker;Process;programs;Publishing;Recommendation;Recording of previous events;repaired;Reporting;Role;Schools;Severities;sex;Small RNA;social stress;sound;sperm cell;Spermatogenesis;stressor;Testing;Time;toxicant;transmission process;United States;Untranslated RNA;Variant;virtual;zygote

PROJECT_TITLE: HERITABLE, EPIGENETIC EFFECTS OF PATERNAL ALCOHOL USE ON FASD PHENOTYPES


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Pediatric;Primary Health Care

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative The health of over 200,000 individuals with Down syndrome (DS) in the US is unmeasured, despite increased life expectancy, established syndrome-specific guidelines from the American Academy of Pediatrics, and the NIH’s INCLUDE initiative aiming to improve the health and well- being in DS. This proposal presents a five-year research career development program with training that will position me with a unique set of cross disciplinary skills to enable transition to independence as a physician scientist to study, measure, and improve the health of individuals with DS. The proposed research will result in creation of a validated instrument to measure health status in DS – the Down Syndrome Health Instrument (DHI) – to measure patient- reported health in DS for the first time, allow measurement of health as an outcome to improve care, and to expand the repertoire of measurements for future research.

PI_NAMEs: SANTORO, STEPHANIE LYNN (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Academy;Adherence;Adverse effects;Age;American;Behavioral;Biometry;Body mass index;career;career development;Caregivers;Caring;Clinic;Clinical;Clinical Research;Clinical Trials;Clinical Trials Network;Code;cognitive interview;cohort;Communities;comorbidity;Congresses;Data;design;Development;dimensional analysis;Disease;Down's Syndrome;effectiveness evaluation;Effectiveness of Interventions;Electronics;experience;Face;Factor Analysis;Focus Groups;Foundations;Funding;Future;General Hospitals;General Population;Goals;Guidelines;handicapping condition;Health;health assessment;Health Status;Healthy People 2020;Height;improved;Individual;Information Systems;instructor;instrument;International;Intervention;Interview;Learning;Life Expectancy;Massachusetts;Measurable;Measurement;Measures;Medical;Medical Care Costs;Medical Genetics;Medical Records;medical schools;medical specialties;member;Mental Health;Mentors;Metabolism;Methodology;Methods;Minnesota;Modeling;novel;Obesity;obesity risk;Outcome;Paper;Participant;patient oriented research;Patient Outcomes Assessments;Patients;Pediatric Hospitals;pediatrician;Pediatrics;Personal Satisfaction;Persons;Physicians;Population;population health;Positioning Attribute;primary care clinic;Primary Care Physician;process improvement;Program Development;programs;Psyche structure;Questionnaires;Race;recruit;Registries;Reporting;Research;Research Personnel;Risk;Risk Factors;Sampling;Schools;Scientist;Self Administration;Site;skills;Sleep;Sleep Apnea Syndromes;social factors;Social Well-Being;Statistical Data Interpretation;Surveys;Syndrome;Testing;Time;tool;Training;trait;United States;United States National Institutes of Health;Universities;usability;user-friendly;Validation;Weight;Work;World Health Organization

PROJECT_TITLE: Developing a Down Syndrome Health Instrument

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Biobehavioral and Behavioral Sciences Study Section[CHHD-H]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infertility;Pediatric;Polycystic Ovary Syndrome (PCOS);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE This project seeks to evaluate and understand cumulative lifetime exposure and life course exposure to air pollutants and climate factors during the sensitive time windows of (1) gestation, (2) childhood/premenarche, and (3) adulthood to determine whether prenatal or adult exposures confer greatest risk. We will additionally evaluate disparities in AP exposures and MCC outcomes in a SafetyNet hospital population.

PI_NAMEs: MAHALINGAIAH, SHRUTHI  (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: 15 year old;Acceleration;Acne;Address;Adult;Adult women;Affect;Age;Air Pollutants;Air Pollution;androgen excess;Biological;Biological Factors;Birth;Black race;Boston;burden of illness;Censuses;Cessation of life;Characteristics;Childhood;Chronic;Cities;Climate;climate-related exposures;Clinical;Code;cohort;Cohort Studies;Collection;Counseling;Data;Data Set;Daughter;Diabetes Mellitus;Diagnostic;Disease;Disparity;DNA Repair;Dyslipidemias;Electronic Health Record;Embryo;Endocrine disruption;Enrollment;Environment;Environmental Exposure;Environmental Impact;Environmental Risk Factor;ethnic disparity;ethnic diversity;Exposure to;Fertilization in Vitro;girls;Goals;Growth;Health;Health Promotion;Heart Diseases;high school;Hirsutism;Hispanic;Home;hormonal signals;Hormones;Hospitals;Humidity;Hypertension;Hypothalamic structure;Impairment;Infertility;Inflammation;Irregular Menstruation;Knowledge;Length;Life Cycle Stages;life span;Literature;male;Mammals;Medical center;Menarche;Menstrual cycle;Menstruation;Metabolic syndrome;Minority;Monitor;Nurses;Nurses' Health Study;Obesity;offspring;Outcome;Ovarian Diseases;ovarian dysfunction;Ovary;Oxidative Stress;Participant;Physiological;Pituitary Gland;Polycystic Ovary Syndrome;Population;Pregnancy;Pregnancy loss;premature;prenatal;prenatal exposure;prospective;Race;racial disparity;Recording of previous events;Reporting;reproductive;reproductive function;Reproductive Health;reproductive outcome;Risk;Risk Reduction;safety net;School-Age Population;Seminal fluid;success;telomere;Temperature;Testing;Time;time-to-pregnancy;Toxic effect;United States;Variant;Woman;women's outcomes

PROJECT_TITLE: Climate factors, racial/ethnic disparities, and menstrual cycle health

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Genetics;Human Genome;Infectious Diseases;Microbiome;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PI_NAMEs: RAVEL, JACQUES  (contact)

PROJECT_TERMS: 3-Dimensional;Automobile Driving;Bacteria;bacterial community;Base Sequence;Bioinformatics;Biological;Biomimetics;Biopsy;Catalogs;Cell Line;cell type;Cells;Cervical;cervicovaginal;chemokine;Chlamydia trachomatis;Clinical;Clinical Research;Communities;cost;cost effective;cytokine;Data;Data Analyses;data framework;Data Set;data sharing;DNA;Engineering;Ensure;Environment;experience;Exposure to;Genes;Genetic;Genitalia;genome sciences;Genomics;Goals;Guidelines;High-Throughput Nucleotide Sequencing;host microbiota;Human;Immune;Immunity;Infection;Infrastructure;innovation;Knowledge;Laboratories;Laboratory Research;Laboratory Study;Maintenance;Maryland;medical schools;Metadata;metatranscriptomics;microbiome;microbiota;Modeling;Modernization;Mucous Membrane;Neisseria gonorrhoeae;novel;open data;Organ;pathogen;programs;Protocols documentation;Qualitative Evaluations;Reproducibility;Research;Resolution;Resource Sharing;Resources;response;Rest;RNA;Running;Sampling;Services;Sexually Transmitted Diseases;Specimen;Structure;Swab;System;Technology;Testing;Time;Tissues;tool;Training;transcriptome;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Universities;Vagina

PROJECT_TITLE: Omics/Clinical Core


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: DALLAS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative (2-3 sentences) As a class of endogenous regulatory molecules, microRNAs play a key role in proper gene expression and are necessary for stem cells maintenance, cellular and organ development, response to cellular signaling or stress, and proliferation. Almost all microRNAs undergo mandatory maturation steps to become functional and understanding the molecular mechanism of microRNA biogenesis and its regulation will be fundamentally important for a wide range of diseases including cancer, developmental diseases, diabetes, and metabolic syndromes.

PI_NAMEs: NAM, YUNSUN  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Address;Affect;Affinity;Apical;arm;Binding;Biochemical;Biochemistry;Biogenesis;Biological Assay;Biology;Cell Maintenance;cellular development;Complex;Cryoelectron Microscopy;Defect;Detection;Development;developmental disease;Diabetes Mellitus;Disease;Distal;Double-Stranded RNA;Enzymes;Family;Future;Gene Cluster;Gene Expression;Gene Expression Regulation;Genes;Genome;Goals;grasp;helicase;Human;In Vitro;Individual;insight;Knowledge;Left;Libraries;Link;Malignant Neoplasms;Metabolic syndrome;Microprocessor;MicroRNAs;Modeling;Molecular;mutant;novel;organ growth;Play;preference;Process;Proliferating;protein expression;Proteins;recruit;Regulation;Regulator Genes;Research;response;Rest;Ribonuclease III;RNA;RNA Sequences;Role;SAFB gene;Signal Transduction;Site;Specificity;stem;stem cells;stoichiometry;Stress;Structure;Substrate Specificity;success;Tertiary Protein Structure;three dimensional structure;Transcript;Untranslated RNA;Work;X-Ray Crystallography

PROJECT_TITLE: Mechanisms of Microprocessor Function and Regulation

STUDY_SECTION: MGA

STUDY_SECTION_NAME: Molecular Genetics A Study Section[MGA]


NIH_SPENDING_CATS: HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: PITTSBURGH

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: The germinal center (GC) is a fascinating microanatomic structure in the immune system that is the major source of strong and long lived antibody-mediated immunity. This is critical for how vaccines work and why we don’t get naturally reinfected. The GC is inhabited by B lymphocytes (responsible for antibodies) that differ greatly from non-GC B lymphocytes, and these differences must be critical for function, but they are not understood. This proposal investigates the deep cellular and molecular mechanisms that underlie how GC cells function and interpret signals that lead them to make such effective and long-lived cells.

PI_NAMEs: SHLOMCHIK, MARK J (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Address;Affect;Affinity;Anatomy;Antibodies;Antibody-mediated protection;Antigen Presentation;Attenuated;B cell differentiation;B-Lymphocytes;BCL6 gene;Biology;c-myc Genes;Cell Cycle;Cell Death;Cell Lineage;Cell Nucleus;Cell Physiology;Cells;Cellular biology;Cessation of life;Chromatin;Cytokine Signaling;Cytoplasm;Development;Epigenetic Process;epigenome;Event;experimental study;fascinate;Funding;Gene Expression;Generations;Haptens;Humoral Immunities;Immune system;Immunoglobulin Somatic Hypermutation;In Vitro;in vitro Model;in vivo;Influenza;insight;interleukin-21;interleukin-21 receptor;Lead;Link;Maintenance;Memory;Memory B-Lymphocyte;Microanatomy;Modeling;Molecular;NF-kappa B;novel strategies;Outcome;Pathway interactions;Periodicity;Phase;Phosphorylation;Phosphotransferases;PIK3CG gene;Plasma Cells;precursor cell;preservation;Principal Investigator;Process;programs;Reaction;receptor;recruit;response;self-renewal;Signal Transduction;Source;Spleen;Structure of germinal center of lymph node;Surface;T-Lymphocyte;Testing;TNFRSF5 gene;transcription factor;Transcription Repressor;Vaccination;Vaccines;Work

PROJECT_TITLE: Signaling and Selection in Germinal Center B Cells

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Autoimmune Disease;Genetics;Lupus

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Address;Age Months;age related;Agonist;Animal Model;Autoantibodies;B-Lymphocytes;Biochemical;Biological;Biology;cell type;Cells;Chromatin;Data;Disease;DNA;Endosomes;Experimental Designs;experimental study;Funding;Genetic;genetic approach;Goals;Image;Immune;improved;in vivo;inducible Cre;Inflammatory;inhibitor;insight;Laboratories;LoxP-flanked allele;Lupus;Macrophage;Maintenance;Maps;Methods;Modeling;Molecular;Mus;mutant;Mutant Strains Mice;neutrophil;novel;Nucleic Acids;overexpression;Pathway interactions;Phenotype;Production;Property;rational design;Receptor Inhibition;Receptor Signaling;Regulation;risk variant;Role;Series;Signal Pathway;Signal Transduction;systemic autoimmune disease;systemic autoimmunity;Systemic Lupus Erythematosus;Testing;Therapeutic;therapeutic evaluation;Therapeutic Uses;Tissue Engineering;Tissues;TLR7 gene;TLR8 gene;Toll-like receptors;Work

PROJECT_TITLE: Investigating How TLR7 Activates and TLR9 Regulates Systemic Autoimmunity

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Neurosciences;Nutrition;Obesity;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: Columbus

ORG_DEPT: NEUROSCIENCES

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Spinal cord injury disrupts systemic organ function, including prolonged fat accumulation and inflammation in the liver, which negatively affect overall recovery and systemic metabolic function. This increases the risk for diabetes and cardiovascular disease, a leading cause of death in the SCI population. This pre-clinical work seeks to identify therapeutic targets to reduce liver pathology and improve after overall metabolic health SCI.

PI_NAMEs: MCTIGUE, DANA M (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Acute;Adrenergic Agents;Affect;Autonomic nervous system;Biological Models;cardiometabolic risk;Cardiovascular Diseases;Cause of Death;cell injury;Cells;Central obesity;Ceramides;Chronic;Complex;Data;design;designer receptors exclusively activated by designer drugs;Development;diabetes risk;Disease;Disinhibition;Dyslipidemias;Eating;Endocrine;Enzymes;experimental study;Fatty acid glycerol esters;General Population;Genetic;Genetic Transcription;Goals;Health;Hepatic;Hepatocyte;High Fat Diet;high risk;Homeostasis;Hyperactivity;Hyperglycemia;Hypertension;improved;Individual;Inflammation;Inflammation Mediators;Inflammatory;Injury;insight;Insulin Resistance;Interruption;Intervention;Kupffer Cells;life span;Link;lipid metabolism;lipidomics;Lipids;Liver;Liver diseases;liver function;liver inflammation;Liver neoplasms;Liver parenchyma;Mediator;Metabolic;Metabolic dysfunction;Metabolic syndrome;Molecular Target;Morbidity - disease rate;mouse genetics;neurological recovery;Neurons;NF-kappa B;NF-Kappa B p65;Non obese;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;Norepinephrine;novel;Nutritional and Metabolic Diseases;Obesity;Operative Surgical Procedures;Organ;Pathology;Pathway interactions;Play;Population;pre-clinical;Prevalence;Rattus;Recovery;Reporting;Risk;Rodent;Role;sedentary lifestyle;serine palmitoyltransferase;Signal Induction;Signal Transduction;single-cell RNA sequencing;Spinal Cord;Spinal cord injury;statistics;Stroke;Sympathectomy;Sympathetic Nervous System;System;Systemic disease;Technology;Testing;therapeutic target;TNF gene;Transgenic Mice;Transgenic Organisms;Work

PROJECT_TITLE: Spinal cord injury causes liver pathology and metabolic dysfunction

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Infectious Diseases;Microbiome;Sexually Transmitted Infections;Women's Health Research

PROJECT_TERMS: 3-Dimensional;Anaerobic Bacteria;Animals;Atopobium vaginae;Bacterial Vaginosis;Biological;Biological Factors;Biological Models;Biomimetics;Cell Culture Techniques;Cell Physiology;Cells;cervicovaginal;Chlamydia Infections;Chlamydia trachomatis;comparative;Complex;Data;Disease Progression;Environment;Epithelial Cells;Epithelium;Ethics;Gardnerella vaginalis;Genetic Transcription;Goals;Histologic;Histology;Homeostasis;host microbiota;Human;immune function;Immune response;Immunity;Immunologics;in vivo;Indigenous;Infection;innovation;Intervention;Knowledge;Knowledge acquisition;Lactobacillus;metabolomics;Metagenomics;metatranscriptomics;Methodology;microbial composition;microbiome;microbiota;microbiota composition;microorganism;Modeling;Mucous body substance;Mucous Membrane;Outcome;Pathogenesis;Pattern;permissiveness;pre-clinical assessment;Preclinical Testing;Predisposition;prevent;Preventive;Prevotella;Process;programs;Property;Research;Resistance;restoration;Risk;Role;Seminal fluid;Series;Severity of illness;Sexually Transmitted Agents;Sexually Transmitted Diseases;Structure;Syndrome;Testing;Therapeutic;tool;transcriptome sequencing;vaginal microbiota;Woman

PROJECT_TITLE: Host-Microbiota Interactions and STI Outcomes


ORG_CITY: MINNEAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative HIV is not able to be cured with current therapies and patients continue to have profound immune abnormalities with increased morbidity and mortality when compared to age-matched HIV negative controls. These increased co-morbidities are related to immune activation that we believe is caused by ongoing low- level virus production and/or replication in lymphoid tissues during ART. The primary hypothesis we will explore is that IA during ART is driven by virus producing cells and/or cells expressing viral antigens that is caused by intracellular concentrations (IC) of antiretroviral (ARV) drugs in LT that do not completely inhibit virus replication which creates a barrier to cure and complete immune reconstitution.

PI_NAMEs: SCHACKER, TIMOTHY W (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Address;Age;Anatomy;Anti-Retroviral Agents;antibody test;Antigens;antiretroviral therapy;B-Lymphocytes;Biological Assay;C-reactive protein;cardiovascular disorder risk;CD4 Positive T Lymphocytes;cell envelope;Cells;Circulation;Coagulation Process;Collection;comorbidity;Cytomegalovirus;Data;Detection;detection limit;Development;endothelial dysfunction;experience;Fibrin fragment D;Foundations;Frequencies;Future;Gene Expression Profile;Genes;genetic signature;Genetic Transcription;Health;Helper-Inducer T-Lymphocyte;Herpesviridae;Herpesviridae Infections;high throughput screening;HIV;HIV envelope protein;HIV Infections;HIV Seronegativity;Human Herpesvirus 4;Image Analysis;Immune;immune activation;immune reconstitution;Immune response;Immunologic Stimulation;improved;In Situ Hybridization;Individual;Infection;Interleukin-6;Interruption;Interstitial Nephritis;Investigation;Link;Lymphoid Tissue;Measurement;Measures;Metabolic;Methods;microbial;Mononuclear;Morbidity - disease rate;mortality;neutralizing antibody;Outcome;Pathology;Patients;Pharmaceutical Preparations;Phenotype;Plasma;Production;Proliferating;Pulmonary Hypertension;quantitative imaging;Research;Rest;RNA;Serum Markers;Simplexvirus;Site;Source;Strategic Planning;T-Lymphocyte;T-Lymphocyte Subsets;Technology;Testing;Tissues;TNF gene;transcriptomics;translational approach;United States National Institutes of Health;Viral;Viral Antigens;viral detection;Viral Load result;Viral reservoir;Virion;Virus;Virus Replication;Work

PROJECT_TITLE: Investigation of persistent HIV immune stimulation in lymphoid tissues during therapy as a cause of sustained immune activation

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Sleep Research

ORG_CITY: ATLANTA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: MOREHOUSE SCHOOL OF MEDICINE

ORG_STATE: GA

PHR: Project Narrative / Relevance The circadian clock in the hypothalamic suprachiasmatic nucleus (SCN) of the mammalian brain is a compact neural net- work which can be studied as a simplified model of the entire central nervous system. A major limitation in investigations of neural circuits to-date has been the need to section the brain, destroying most of the network, and divorcing it from its sensory inputs or behavioral outputs. We propose to employ in vivo real-time Ca2+ imaging in the SCN to study cell-type specific rhythmic generation, the network processing of light input that leads to changes in the circadian behavioral rhythm, and how these mechanisms falter during the process of aging.

PI_NAMEs: DAVIDSON, ALEC J (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Acute;Affect;Afferent Neurons;Aging;aging process;Anatomy;Behavior;Behavioral;Biological Clocks;Brain;cell type;Cells;Central Nervous System;circadian;circadian behavioral rhythms;circadian biology;circadian pacemaker;Divorce;Eye;fluorescence imaging;functional adaptation;Generations;Goals;Hypothalamic structure;Image;in vivo;Investigation;Learning;Light;Microscope;miniaturize;Modeling;Nervous System;neural;neural circuit;neural network;Neurons;Output;Periodicity;Phenotype;Physiological;Physiology;Population;Process;programs;Property;Research;response;sensory input;Sensory Process;Signal Transduction;Sleep;Specificity;suprachiasmatic nucleus;System;Time;Visualization

PROJECT_TITLE: Visualizing hierarchical processing of photic input to the circadian clock in vivo

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Immunotherapy;Precision Medicine;Women's Health Research

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: Immunotherapy is a promising new approach for cancer treatment, but only a fraction of patients respond to treatment, with a majority experiencing drug related side effects. Current screening methods for immunotherapy biomarkers rely on biopsy, which is invasive and does not always provide an accurate readout of biomarker status in whole tumors. This proposal will develop a whole-body optical imaging technique that can quantify biomarkers non-invasively, thereby enabling the efficient development of new combination treatments and more accurate screening for predictive biomarkers, potentially saving non-responders from ineffective treatments and life-threatening effects.

PI_NAMEs: DUDA, DAN GABRIEL;KUMAR, ANAND T.N. (contact)

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: 4T1;Address;Age of Onset;angiogenesis;Antibodies;antibody conjugate;Behavior;Biological Markers;Biopsy;blood perfusion;Blood Vessels;Blood Volume;Breast;Breast Cancer Model;Breast Cancer Patient;breast imaging;Bypass;cancer cell;cancer therapy;chemotherapy;Clinical;Clinical Trials;clinically relevant;Combined Modality Therapy;cost;Data;design;Detection;Development;diffuse optical tomography;Disease;Environment;Evaluation;experience;extracellular;Fluorescence;fluorescence imaging;fluorescence lifetime imaging;Fluorescent Dyes;fluorophore;Goals;Histology;Hypoxia;Image;Imaging Techniques;Immune;Immune system;Immunologic Receptors;Immunotherapy;improved;in vivo;in vivo Model;ineffective therapies;instrumentation;Interferon Type II;Label;Life;lymph nodes;Malignant Neoplasms;Methods;Molecular;molecular imaging;molecular marker;Monitor;Mus;near infrared dye;new combination therapies;non-invasive imaging;non-invasive monitor;Nonionizing Radiation;Normal tissue morphology;novel strategies;optical imaging;Optics;Organ;Paclitaxel;patient population;Patients;Perfusion;Pharmaceutical Preparations;Physiological;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;predictive marker;Prognosis;programmed cell death ligand 1;programmed cell death protein 1;receptor;Resistance;response;screening;Sensitivity and Specificity;side effect;Signal Transduction;Standardization;Survival Rate;Techniques;Technology;Time;time use;Tissues;tomography;tool;Translating;Treatment Efficacy;Treatment Protocols;treatment response;Treatment Side Effects;triple-negative invasive breast carcinoma;tumor;tumor hypoxia;Tumor Markers;uptake;Validation

PROJECT_TITLE: Multiplexed time domain fluorescence tomography of tumor biomarkers during immunotherapy


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Dissemination and Implementation Research;Health Services;Heart Disease;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SAO PAULO

ORG_COUNTRY: BRAZIL

ORG_FIPS: BR

ORG_NAME: FUNDACAO FACULDADE DE MEDICINA

PHR: PROJECT NARRATIVE There are many barriers that patients with Chagas Disease have to overcome to obtain a diagnosis, adequate treatment, and appropriate follow-up. We plan to develop strategies to allow the timely and effective use of health services to identify and treat Chagas patients. We also plan to detect biomarkers associated with heart disease inflammation and validate its clinical relevance in a large cohort of treated patients.

PI_NAMEs: SABINO, ESTER CERDEIRA (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Antibodies;Area;Articulation;Artificial Intelligence;Benznidazole;Biological Markers;biomarker identification;biomarker panel;biomarker validation;candidate marker;Cardiac;Cardiomyopathies;Central America;Chagas Disease;Chronic;Clinical;clinically relevant;cohort;Data;Data Collection;Diagnosis;diagnostic strategy;digital health;Disease Marker;efficacy validation;Enrollment;Etiology;follow-up;health care availability;health service use;Health system;Healthcare Systems;Heart Diseases;heart imaging;Imaging Techniques;implementation framework;implementation science;improved;Inflammation;Knowledge;Latin America;Lesion;Magnetic Resonance;Maps;Measures;Methodology;Methods;Morbidity - disease rate;mortality;Myocardial;Myocardial tissue;Natural History;neglect;patient-level barriers;Patients;Persons;Plasma;Positron-Emission Tomography;Primary Health Care;Process;prospective;Prospective cohort;Protocols documentation;Registries;Research;Research Personnel;response;Sampling;success;Surrogate Markers;Testing;tool;Treatment Efficacy;Tropical Medicine;Trypanocidal Agents;Trypanosoma cruzi

PROJECT_TITLE: "Sao Paulo-Minas Gerais Center for Chagas Disease Treatment (SaMiTrop)"


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Contraception/Reproduction;Infectious Diseases;Microbiome;Prevention;Sexually Transmitted Infections;Women's Health Research

PI_NAMEs: DERRE, ISABELLE  (contact)

PROJECT_TERMS: 3-Dimensional;Address;Adverse effects;Affect;anti-microbial peptide;Antibiotics;Bacteria;Bacterial Infections;Binding;Biological;Biological Models;Biology;Biomedical Engineering;Biomimetics;Cell Culture Techniques;cell type;Cells;cervicovaginal;Characteristics;chemokine;Chlamydia;Chlamydia Infections;Chlamydia trachomatis;Collaborations;cost effective;cytokine;Cytosol;Ectopic Pregnancy;Endocrine;Environment;epidemiology study;Epithelial Cells;Epithelium;Equilibrium;Estradiol;Goals;Gonadal Steroid Hormones;Growth;Homeostasis;Human;Immune;Immune response;Immunity;Individual;Infection;infection rate;Infertility;Innate Immune Response;Intervention;Invaded;Knowledge;Left;long-term sequelae;Membrane;Menstrual cycle;microbiome;Modeling;Mucous body substance;Mucous Membrane;Mus;neutrophil;novel therapeutics;Outcome;pathogen;Pathology;Pelvic Inflammatory Disease;Phase;Physiological;Physiology;Predisposition;prevent;Process;Production;Productivity;Progesterone;reconstitution;reproductive tract;Resistance to infection;response;Role;Sexual Transmission;Sexually Transmitted Diseases;Site;Stromal Cells;Structure;Testing;Tight Junctions;Time;Tissues;trafficking;transmission process;vaccine access;Vaccines;Vagina;vaginal microbiota;Woman;women's reproductive health

PROJECT_TITLE: The Effects of Sex Hormones on Chlamydia Infection


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Genetics

ORG_CITY: FARMINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Integrations of transposable elements (TE) account for ~45% of our genomes, and although most are now inactive, they have provided the genetic diversity to shape the evolution of our cellular and organismal responses to stress. Here, we expand on findings that the RNA-binding proteins (RBPs) that bind to these TE have critical roles in the regulation of endothelial cell activation and immune cell recruitment in the inflamed arteria intima. Our findings will provide important insight into this special class of RBPs, to better understand and treat chronic inflammation in atherosclerosis, aneurysm, and other cardiovascular diseases.

PI_NAMEs: MURPHY, PATRICK ANDRIES (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Affect;Alternative Splicing;Aneurysm;Arterial Fatty Streak;Arterial Intimas;Atherosclerosis;Behavior;Binding;Binding Proteins;Biological;Biological Assay;Blood Vessels;Cardiovascular Diseases;Cardiovascular system;CD8-Positive T-Lymphocytes;Cell Adhesion Molecules;Cells;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;CRISPR screen;cytokine;Cytoprotection;Data;Dependence;design;Disease;DNA Transposable Elements;Endothelial Cells;Endothelium;Equilibrium;Event;Evolution;Exons;extracellular;Extracellular Matrix Proteins;falls;Family;Fibronectins;Flow Cytometry;Future;Genes;Genetic Transcription;Genetic Variation;Genome;genomic locus;Histology;Human;Human Genome;Immune;immune function;Immune system;Immunity;In Vitro;in vivo;in vivo evaluation;Inflammation;Inflammatory;Inflammatory Response;Injury;insight;intercellular cell adhesion molecule;Introns;Knowledge;Lesion;Link;link protein;Long Interspersed Elements;Mediating;Modeling;monocyte;mouse genome;NF-kappa B;novel;Nuclear RNA;oxidized low density lipoprotein;pathogen;Pathogenicity;Pattern;Post-Transcriptional Regulation;posttranscriptional;Process;programs;Property;Proteomics;Quantitative Trait Loci;recruit;Regulation;Regulator Genes;response;Risk;RNA;RNA Binding;RNA Splicing;RNA-Binding Proteins;Role;Rupture;Shapes;Signal Transduction;Site;Sterility;Stress;System;T cell differentiation;T cell therapy;T-Lymphocyte;Testing;Therapeutic;Tissue Preservation;Titrations;Transcript;Transgenic Mice;Variant;Vascular Cell Adhesion Molecule-1;vascular inflammation

PROJECT_TITLE: RNA-Binding Proteins in the Regulation of Vascular Inflammation and Immunity

STUDY_SECTION: AICS

STUDY_SECTION_NAME: Atherosclerosis and Inflammation of the Cardiovascular System Study Section[AICS]


ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative: C-C Bond formation is central to chemical synthesis. We have pioneered a broad, new family of metal-catalyzed carbonyl reductive couplings that exploit feedstock pronucleophiles in combination with safe, inexpensive feedstock reductants (H2, 2-PrOH, HCO2H), and related H2-autotransfer processes (ROH = reductant & proelectrophile) that directly convert lower alcohols to higher alcohols. In the proposed funding period, this reactivity pattern will be extended to couplings of α-olefins and C-X pronucleophiles, the use of amine proelectrophiles, the formation of quaternary stereocenters and use of base metal catalysts.

PI_NAMEs: KRISCHE, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Catalytic C-C Bond Forming Hydrogenations

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hepatitis;Liver Cancer;Liver Disease;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: 8. PROJECT NARRATIVE Cirrhosis–the end-stage result of chronic liver disease–is an increasingly common condition that results in significant morbidity and frequent hospitalization, all disproportionately affecting racial/ethnic minorities and socioeconomically disadvantaged patients. This project represents the first necessary step in developing interventions to reduce these disparities and improve survival in racial/ethnic minority and socioeconomically disadvantaged populations. We will follow a large group of patients with cirrhosis to identify factors that explain these health disparities, with a special focus on reasons that can be changed with prevention and treatment.

PI_NAMEs: KANWAL, FASIHA  (contact);SINGAL, AMIT

PROGRAM_OFFICER_NAME: MOMIN, BEHNOOSH RAMJI

PROJECT_TERMS: Adherence;Affect;Alcohol consumption;Alcohols;Ascites;Asian Pacific Islander;barrier to care;Behavioral;Biological;biomedical referral center;Black Populations;Black race;Caring;chronic liver disease;Cirrhosis;Clinical;clinical database;cohort;Cohort Studies;Collaborations;college;Communities;community-level factor;Compensation;Computerized Medical Record;Data;Diabetes Mellitus;Diagnosis;Disease;Disease Outcome;Disparate;Disparity;disparity reduction;Distal;Economically Deprived Population;Epidemiologist;ethnic disparity;ethnic minority;Ethnic Origin;Etiology;Evaluation;experience;Funding;Genetic;genetic variant;genomic data;Health;health disparity;health literacy;health outcome disparity;Health Personnel;Health Services;Health system;Healthcare;Healthcare Systems;Hepatic;Hepatic Encephalopathy;Hepatitis B Virus;Hepatitis C;Hepatitis C virus;Hispanic;Hispanic Populations;Hospitalization;Hospitals;implicit bias;improved;Individual;Inequality;insight;interest;Intervention;Liver;Liver diseases;liver function;low socioeconomic status;Measures;Mediating;Mediation;Medical;Medical center;medical specialties;Medicine;Morbidity - disease rate;mortality;National Institute on Minority Health and Health Disparities;Not Hispanic or Latino;Obesity;Outcome;participant enrollment;Pathway interactions;patient subsets;Patients;Persons;Physical environment;Play;Policies;Population Heterogeneity;practice setting;Prevalence;Prevention;Primary carcinoma of the liver cells;Prognosis;prognostic;prospective;Prospective Studies;Provider;Quality of Care;Race;racial determinant;racial disparity;racial minority;Reporting;Research;Research Personnel;Risk Behaviors;Risk Factors;Role;safety net;Scientist;segregation;Severity of illness;Single Nucleotide Polymorphism;Site;Smoking;social culture;Social support;socioeconomic disadvantage;socioeconomic disparity;Socioeconomic Status;socioeconomics;study population;Surveys;System;tertiary care;transportation access;United States Department of Veterans Affairs;Visit

PROJECT_TITLE: Multi-level Evaluation of Racial/ethnic Disparities in Liver Disease Outcomes

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease;Lymphatic Research;Sleep Research

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative There is increasing evidence that disruption of our 24-hour (circadian) clock impairs the immune response increasing the risk to several different diseases, including cancer, obesity, diabetes, and chronic diseases of the gut. Despite this general knowledge it remains largely unknown how disruption of the 24-hour clock impairs human immunity at a molecular and cellular level. Here we propose to delineate how the complement system affects immunity and inflammation in a circadian dependent manner, which may lead to novel therapeutic targets for the treatment of disease pathologies caused by disruption of the 24-hour circadian clock.

PI_NAMEs: MAHAN, KRISTIN ECKEL (contact);SHIVSHANKAR, POOJA

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Affect;Anaphylatoxins;Animals;Applications Grants;Arrhythmia;Asthma;Behavioral;Biological Clocks;C3AR1 gene;Cells;Chronic;Chronic Disease;circadian;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Colitis;Complement;Complement 3a;Complement 5a;Complement Activation;Complement Receptor;complement system;cytokine;Data;design;Development;Diabetes Mellitus;Digestive System Disorders;Disease;experimental study;Functional disorder;gastrointestinal;Gastrointestinal Diseases;Gastrointestinal tract structure;Genetic;Genetic Complementation Test;Goals;Gut associated lymphoid tissue;Health;Histologic;Host Defense;Hour;Human;Human Biology;Image;Immune;Immune response;Immune System Diseases;Immunity;Immunoassay;Impairment;in vivo;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Innate Immune Response;Intestinal Content;Intestines;Jet Lag Syndrome;knockout animal;Knockout Mice;Knowledge;Light;Link;Lymph;Lymphatic;Lymphatic function;Lymphatic System;Lymphoid Tissue;Malignant Neoplasms;Mediating;Modeling;Molecular;mouse model;Mus;mutant;new therapeutic target;novel;Obesity;Output;Pacemakers;Pathogenesis;Pathology;Patients;Peptides;Periodicity;Peripheral;Peyer's Patches;Phase;Physiology;polarized cell;Population;Property;receptor;Receptor Signaling;Regulation;response;Risk;Role;Rotation;Signal Transduction;Source;suprachiasmatic nucleus;System;T-Lymphocyte;Testing;Th1 Cells;Therapeutic;Time;Tissues;tool;transcriptome sequencing

PROJECT_TITLE: Complement and Circadian Interactions in Inflammation and Immunity

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Biotechnology;Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE  microRNAs are an extensive class of ~22 nucleotide RNAs that mediate broad networks of gene regulation, and their dysfunction is linked to disease and cancer. We uncovered new mechanisms that govern selective microRNA biogenesis, and linked this to specific cancers. We will integrate biochemical, molecular, genetic and genomewide approaches to elucidate new microRNA mechanisms, their exploitation as gene silencing vectors, and their impact on disease.

PI_NAMEs: LAI, ERIC C (contact)

PROJECT_TERMS: Address;Binding;Biochemical;Biogenesis;Biological;Biological Assay;Biology;Bypass;Cell model;cofactor;cohort;Complex;Coupling;Cytoplasm;Data;Defect;design;DICER1 gene;Disease;Enzymes;Exposure to;fly;Foundations;Functional disorder;gain of function;Gene Expression;Gene Expression Regulation;gene network;Gene Silencing;Genetic;genome-wide;Genomic approach;Genomics;Goals;Grant;Human;Human Biology;human disease;human embryonic stem cell;imaging approach;improved;In Vitro;in vivo;insight;interdisciplinary approach;Knock-out;Learning;Link;loss of function;Malignant Neoplasms;Mediating;Microprocessor;MicroRNAs;Modeling;Molecular;mutant;Mutation;novel;Nuclear;Nucleotides;Operon;Outcome;Pathway interactions;Phenotype;Positioning Attribute;Post-Transcriptional Regulation;posttranscriptional;Process;Proteins;Publications;recruit;Recurrence;Recurrent disease;Regulation;Reporter;Reporting;Ribonuclease III;RNA;RNA Interference;SAFB gene;single molecule;Small RNA;Specificity;stem;Syndrome;System;Testing;Time;Transcript;transcription regulatory network;Up-Regulation;vector;Work

PROJECT_TITLE: Selective regulatory and biogenesis mechanisms for microRNAs

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Contraception/Reproduction;Infectious Diseases;Microbiome;Pelvic Inflammatory Disease;Sexually Transmitted Infections;Women's Health Research

PI_NAMEs: CRISS, ALISON K (contact)

PROJECT_TERMS: 3-Dimensional;Address;Affect;Anaerobic Bacteria;Antibiotics;antimicrobial;Architecture;Autologous;Bacterial Vaginosis;Biology;Biomimetics;Cells;Cervical;cervicovaginal;Cervix Uteri;Chlamydia;Chlamydia trachomatis;co-infection;Communicable Diseases;Communities;defense response;Ectopic Pregnancy;Environment;Epidemiology;Epithelium;Exudate;Female genitalia;female reproductive tract;genital infection;genital microbiota;Gonorrhea;Gram-Negative Bacteria;Health;Host Defense;host microbiota;Human;Immune;Immune response;Immunity;Infection;Infertility;Infiltration;Inflammation;Inflammatory Response;Intervention;Knowledge;Lactobacillus;Microbe;microbial;microbiome;microbiota;Modeling;Mucosal Immune Responses;Mucous Membrane;Neisseria gonorrhoeae;neutrophil;Neutrophil Infiltration;novel therapeutic intervention;Outcome;pathogen;Pathogenesis;Pelvic Inflammatory Disease;permissiveness;Predisposition;Process;Productivity;programs;Public Health;Recommendation;recruit;reproductive;reproductive fitness;Resistance;resistance frequency;response;Sexually Transmitted Diseases;Structure;System;therapy development;Time;Tissues;transmission process;Vaccines;Vagina;Woman;Women's Health;women's outcomes

PROJECT_TITLE: Polymicrobial Context of Neisseria gonorrhoeae Infection and Mucosal Immune Response


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Estrogen;Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Regenerative Medicine;Rehabilitation;Spinal Cord Injury;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Traumatic Head and Spine Injury

ORG_CITY: SAN JUAN

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: Project Narrative:  Spinal cord injury (SCI) generates a cascade of events resulting in loss of voluntary movement and muscle degeneration. This study is innovative because it seeks to slow down this degenerative process through the use of Tamoxifen, early after SCI, and to maintain the contractile properties of skeletal muscles, as well as the appropriate expression of myosin heavy chain proteins in muscle fiber. We will also determine some of the mechanisms activated or de-activated by TAM in muscle cells using metabolomic analyses and if the drug provides an appropriate environment for satellite cell proliferation and/or muscle regeneration in male and female rats, which may lead to novel therapeutic strategies to enhance functional recovery early after SCI.

PI_NAMEs: MIRANDA, JORGE DAVID (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Acute;Animal Model;Animals;Antineoplastic Agents;Apoptosis;Area;Atrophic;Axon;Cell Proliferation;cell regeneration;Data;Desmin;Development;Devices;effective therapy;Embryo;Environment;Estradiol;Estrogen Receptors;Event;Exercise;exercise program;exercise rehabilitation;experimental study;FDA approved;Female;Fiber;Human;Implant;improved;Inflammation;injured;Injury;innovation;Laboratories;Locomotor Recovery;male;Metabolic;metabolic profile;metabolomics;Molecular;Motor Activity;motor recovery;Movement;Muscle;Muscle Cells;muscle degeneration;Muscle Fibers;muscle physiology;muscle regeneration;Muscle satellite cell;Muscular Atrophy;Myogenin;Myosin ATPase;Myosin Heavy Chains;Natural regeneration;Nerve;Nerve Regeneration;Nerve Tissue;neural;neuron loss;neuronal circuitry;novel therapeutic intervention;Pain;Paralysed;Pathway interactions;Patients;Perception;Pharmaceutical Preparations;Pharmacological Treatment;Phase;preservation;prevent;Process;Proliferating;Property;protein degradation;Protein Isoforms;Proteins;Rattus;Recovery;Recovery of Function;regenerative;repaired;Reporting;Research;Research Personnel;response;Selective Estrogen Receptor Modulators;sex;Sex Differences;sexual dimorphism;Skeletal Muscle;Soleus Muscle;somatosensory;Spinal Cord;Spinal Cord Contusions;Spinal cord injury;Tamoxifen;Testing;Therapeutic;tibialis anterior muscle;Tissues;Trauma;treatment effect

PROJECT_TITLE: Effects of Tamoxifen in skeletal muscle recovery after spinal cord injury and mechanisms activated by the drug


PHR: Project Narrative The goal of this project is to understand how cholesterol interacts with physiologically important membrane proteins to control their signaling functions through modulating conformational changes. We will use a diverse set of biophysical techniques to study cholesterol interactions with Scap, the master regulator of mammalian cholesterol homeostasis, and GPCRs, which transduce signals from hormones and neurotransmitters to intracellular G proteins. Further understanding how cholesterol influences the conformations of these proteins will benefit public health, since Scap is a potential therapeutic target for fatty liver disease, and different GPCRs are important for treating many disorders such as asthma, cardiovascular disease, and Parkinson's disease.

PI_NAMEs: ROSENBAUM, DANIEL  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Address;Architecture;Asthma;atomic data;Binding;Binding Sites;Biological;biophysical techniques;Biophysics;Cardiovascular Diseases;Cholesterol;Cholesterol Homeostasis;CNR1 gene;Complex;Cryoelectron Microscopy;Data;Disease;Drug Modulation;Endoplasmic Reticulum;fatty liver disease;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Goals;GTP-Binding Proteins;hormonal signals;Hormones;Integral Membrane Protein;Length;Ligand Binding;Lipids;Membrane;Membrane Proteins;Molecular Conformation;nanodisk;Neurotransmitters;NMR Spectroscopy;Parkinson Disease;Pathway interactions;Pharmaceutical Preparations;Phospholipids;Physiological;Protein Conformation;Public Health;Regulation;Roentgen Rays;Signal Transduction;Signaling Protein;Structure;Surface;System;therapeutic target;transcription factor;Transcriptional Regulation

PROJECT_TITLE: Membrane signaling protein modulation by lipids and drugs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: TUSCALOOSA

ORG_NAME: UNIVERSITY OF ALABAMA IN TUSCALOOSA

ORG_STATE: AL

PHR: Project Narrative This proposal adapts West Virginia’s successful SEPA-funded Health Sciences & Technology Academy (HSTA) for the innovative purpose of building the pipeline of students to STEM health-related fields including nursing, nurse faculty, nurse scientists, and other biomedical fields from those underrepresented in the nursing workforce and from underserved rural communities in Alabama. HSTA-Alabama will provide professional development to teachers to build science content and pedagogical skills for use with HSTA-Alabama students and to use in their classrooms. Through a focus of addressing obesity in Alabama and its corresponding sequelae including cardiovascular diseases, other risk behaviors, and opioid use prevention, using a citizen science approach, we will mentor and facilitate professional preparedness of high school students from underserved communities for college and careers in STEM fields, and in particular into academic nursing and nursing science by empowering them to become agents of change in their own communities.

PI_NAMEs: JOHNSON, PAIGE TURNER (contact)

PROGRAM_OFFICER_NAME: BECK, LAWRENCE A

PROJECT_TERMS: Academia;Academy;Address;Affect;African American;Alabama;Ally;American;Apis;Area;biomedical profession;Black race;Cardiovascular Diseases;Cardiovascular system;career;citizen science;Collaborations;college;Communities;community based participatory research;community college;County;Creativeness;Decision Making;design;Development;Discipline of Nursing;economic disparity;Economically Deprived Population;Education;Educational process of instructing;Educational workshop;Effectiveness;empowerment;Environment;ethnic minority population;Ethnic Origin;experience;Exposure to;falls;Family;Family dynamics;Funding;Future Teacher;Geographic Locations;Goals;graduate school;hatching;Health;health disparity;health literacy;Health Sciences;Health Technology;Healthcare;high school;High School Student;improved;Infrastructure;innovation;interest;Joints;Leadership;Learning;Learning Skill;Life Experience;Measures;member;Mentors;Minority;Modeling;National Institute of General Medical Sciences;ninth grade;Nurses;Nursing Education;Nursing Faculty;Obesity;Obesity associated cardiovascular disease;opioid abuse prevention;opioid use;Outcome;Ownership;Patient-Focused Outcomes;Patients;peer coaching;people of color;Personal Communication;Persons;Population;Prevention;programs;Psychometrics;Race;racial minority population;Readiness;recruit;Research;Resources;Risk Behaviors;Rural;rural area;Rural Community;rural counties;rural residence;rural underserved;scale up;Science;Science, Technology, Engineering and Mathematics Education;Scientist;skills;statistics;STEM field;student participation;Students;summer institute;supportive environment;teacher;Testing;theories;Time;underserved area;underserved community;Universities;university student;West Virginia;Workforce Development

PROJECT_TITLE: The Health Sciences & Technology Academy – Alabama (HSTA-AL)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cancer;Clinical Research;Data Science;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Palliative Care

ORG_CITY: BURLINGTON

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: PROJECT NARRATIVE In order to understand, disseminate, support and incentivize high quality communication in serious illness, we need measurement methods that can be scaled for larger clinical studies and routine health service quality reporting. We propose to apply state-of-the-art artificial intelligence methods (Deep Learning Neural Networks) to develop such measures using existing cohort data that includes more than 12,000 minutes of audio- recorded palliative care conversations in the hospital setting. We focus initially on conversational pauses that are indicative of human connection in serious illness conversations.

PI_NAMEs: GRAMLING, ROBERT E (contact);RIZZO, DONNA MARIE

PROGRAM_OFFICER_NAME: CHOU, WEN-YING

PROJECT_TERMS: Adopted;Advanced Malignant Neoplasm;Age;Algorithms;Area;artificial intelligence method;Attention;Award;Caring;Characteristics;Clinical;Clinical Research;Code;cohort;Cohort Studies;Communication;Communication Research;Complex;Confidentiality of Patient Information;Consultations;Consumption;Data;Data Set;deep learning algorithm;deep neural network;design;Ecosystem;Education;Emotions;Environment;Equity;Ethnic Origin;Feeling;Financial Hardship;Gender;Geography;Goals;health care settings;Health Services;Healthcare;Hearing;Hospitalization;Hospitals;Hour;Human;improved;Incentives;Infrastructure;innovation;inpatient service;lexical;Linguistics;Loneliness;Machine Learning;machine learning algorithm;Malignant Neoplasms;Masks;Measurement;Measures;Medical;Methods;Natural Language Processing;NIH Program Announcements;Oxygen;Palliative Care;Participant;Patient Outcomes Assessments;Patients;Performance;person centered;Personality;Persons;Population Heterogeneity;Positioning Attribute;preference;Preparation;Prognosis;Psychologist;Pump;Race;Religion;Reporting;Resources;response;Sampling;Scientist;Security;shared decision making;Site;sociologist;sound;spectrograph;Speech;Strategic Planning;supervised learning;Symptoms;System;Technology;Television;Time;Training;Transcript;Uncertainty;United States;Voice;Work

PROJECT_TITLE: Resubmission- Deep Neural Networks to Identify Moments of Human Connection in Cancer Communication

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: EY

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision

ORG_CITY: LOUISVILLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: PROJECT NARRATIVE This project aims to provide a high-resolution description of the tear film lipid layer which is a thin layer of oil-like molecules that separate tears on the surface of the eye from the ambient air. Physical and chemical properties of the tear film lipid layer have been implicated in the development of dry eye syndrome, which affects 7 million Americans. With an improved, high-resolution description of the tear film lipid layer, researchers can test competing hypotheses about structure, properties, and function of the lipid layer and its relationship to the development of dry eye syndrome.

PI_NAMEs: BORCHMAN, DOUGLAS ;JAEGER, VANCE W (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: 3-Dimensional;Affect;Age Years;Air;Algorithms;American;Behavior;Binding;Biological;Chemical Models;chemical property;Chemicals;Chronic;Compensation;Computer Models;Consensus;Cornea;Data;density;Development;Diffusion;Dry Eye Syndromes;Elasticity;enthalpy;Environment;Etiology;evaporation;experimental study;Eye;eye dryness;Film;fluidity;Generations;Goals;human old age (65+);improved;Knowledge;Lateral;Lead;Lipids;macromolecule;Measures;meibomian gland;Methods;Modeling;Molecular;Molecular Conformation;molecular dynamics;molecular modeling;Molecular Structure;Motion;Nature;NMR Spectroscopy;Nuclear Magnetic Resonance;Oils;pathogen;physical property;Physics;Play;Population;Positioning Attribute;prevent;Probability;Production;Property;Publishing;Rationalization;Research Personnel;Resolution;restraint;Role;Route;Sampling;Signal Transduction;simulation;Spectrum Analysis;Structural Models;Structure;Supplementation;Surface;Surface Tension;Symptoms;System;Techniques;Testing;theories;Therapeutic;therapy design;Thermodynamics;Thick;Thinness;Translating;virtual;Visual;Water;Work

PROJECT_TITLE: Detailed Molecular Structures of Tear Film Lipid Layer for Improved Treatment of Dry Eye Syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Disease;Patient Safety

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Patients with by with patients to principles with cirrhosis have increased surgical risk relative to patients with cirrhosis, and the decision to proceed surgery or pursue non-surgical management is often challenging. This decision however, is heavily driven clinician recommendations given an empiric lack of understanding the perspective and preferences of patients  cirrhosis. This proposal will use a mixed-methods approach to elucidate outcomes that are valued by with cirrhosis when deciding to pursue elective abdominal hernia repair, thereby creating a framework  promote shared decision-making between patients and clinicians and to support patient autonomy — key of medical ethics. ,

PI_NAMEs: MAHMUD, NADIM  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Address;Attitude;Benefits and Risks;Characteristics;Cirrhosis;Client satisfaction;Clinical;clinical practice;Data;Decision Making;demographics;Development;expectation;experimental study;Failure;Functional disorder;Goals;Hemostatic function;Hernia of abdominal cavity;Impairment;improved;innovation;Institution;Interview;Liver;Liver diseases;Medical;Medical Ethics;Methods;Mind;mortality;Operative Surgical Procedures;Outcome;Paternalism;patient expectation;Patient Preferences;Patients;Perioperative;Portal Hypertension;Positioning Attribute;Postoperative Complications;Postoperative Period;predictive tools;preference;Probability;Process;prognostic;Provider;Quality of life;Recommendation;Recovery;Regrets;Relative Risks;repaired;Research;Research Methodology;Research Personnel;Resolution;response;Risk;Risk Assessment;Risk Estimate;risk prediction;risk stratification;Severities;shared decision making;Socioeconomic Status;Structure;surgery outcome;Surgical Management;surgical risk;Surveys;symptomatology;Symptoms;Time;tool;Translating;transplant centers;Weight;willingness

PROJECT_TITLE: Understanding Patient Preferences for Surgical Management in the Setting of Cirrhosis: A Mixed-Methods Approach

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Hematology;Infectious Diseases;Sepsis

ORG_CITY: BOSTON

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Project Narrative The goal of this proposal is to determine how CD14, a protein best known for its role in the recognition of bacterial lipopolysaccharide, facilitates the inflammatory cytokine production, cell death, and in vivo septic immune responses triggered by TNFα, a cytokine that is a prominent effector of septic injury in humans. Based on our preliminary data and our discovery that CD14 has coevolved with TNFα and its receptor, we will examine how CD14 modulates the signaling pathways set in motion by TNFα. While CD14 is understood to play a role in the initiation of inflammation by pathogen-sensing receptors, these studies will clarify how CD14 contributes to runaway sepsis via feedback effects on host cytokine signaling.

PI_NAMEs: BUNNELL, STEPHEN C (contact)

PROGRAM_OFFICER_NAME: LEITNER, WOLFGANG W

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Address;Bacteremia;Biochemical;Biological Models;blocking factor;Bone Marrow;cancer immunotherapy;CD14 gene;CD95 Antigens;Cell Death;Cells;Cessation of life;Clinical;clinically significant;Collaborations;Complex;Coupled;COVID-19;cytokine;cytokine release syndrome;Cytokine Signaling;Cytoplasm;Data;Death Domain;Endosomes;Event;experimental study;Exposure to;Feedback;Foundations;Future;glycosylation;Glycosylphosphatidylinositols;Goals;GPI Membrane Anchors;Human;Immune;Immune response;Immune system;Immune Tolerance;In Vitro;in vivo;in vivo Model;Inflammation;Inflammatory;Inflammatory Response;Injury;Innate Immune Response;insight;Interferon Type I;Interferons;Interruption;Intravenous;IRF3 gene;Knock-out;Learning;lethal factor;Ligand Binding;Ligands;Link;link protein;lipophilicity;Lipopolysaccharides;Macrophage;Maintenance;Mediating;Membrane;Membrane Microdomains;Modeling;Molecular;Motion;mutant;Myeloid Cells;neutrophil;Orthologous Gene;Outcome;pathogen;Pathologic;Pathology;Pathway interactions;Pattern;Phenotype;placental mammal;Polysaccharides;Production;Productivity;Property;Proteins;receptor;receptor function;Receptor Signaling;reconstitution;Recording of previous events;recruit;response;Role;Runaway;Sepsis;sepsis induced ARDS;septic;Signal Induction;Signal Pathway;Signal Transduction;Stromal Cells;Supporting Cell;Syndrome;synergism;System;systemic inflammatory response;TBK1 gene;Testing;Time;Tissues;TLR3 gene;TLR4 gene;TNF gene;TNFRSF1A gene;Toll-like receptors;tool;tumor initiation;Tumor Necrosis Factor Receptor;uptake;Variant;Work

PROJECT_TITLE: CD14 collaborates with TRIF to mediate septic responses downstream of TNF receptors

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Clinical Research;Dementia;Health Services;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Palliative Care

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because respiratory distress in ADRD patients is common in the nursing home and can lead to poor care outcomes. We propose to test the use of a radio sensor to track breathing and implement machine learning methods to predict when a patient may be experiencing respiratory distress. This research aims to contribute to knowledge in our understanding of respiratory distress in the ADRD population living in the nursing home setting.

PI_NAMEs: PHONGTANKUEL, VEERAWAT  (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: acceptability and feasibility;Address;Adopted;Adoption;Adult;advanced dementia;Adverse event;Algorithm Design;Alzheimer's disease patient;Alzheimer's disease related dementia;Antibiotics;Artificial Intelligence;Authorization documentation;Beds;Biosensor;Breathing;Cardiopulmonary;care outcomes;Caring;Categories;Characteristics;Chronic Obstructive Pulmonary Disease;Classification;Clinical;clinical practice;Cognitive;Computer software;Data;Dementia;design;Detection;Development;Devices;Distress;Dyspnea;Elderly;Environment;Etiology;experience;Future;Geriatrics;Goals;Heart failure;Hospitals;Impaired cognition;Impairment;improved;insight;interest;Intervention;Interview;Knowledge;Legal;Machine Learning;machine learning algorithm;machine learning method;Measures;Medicine;member;Methods;Monitor;multidisciplinary;Nurse Practitioners;Nurses;Nursing Homes;Opioid;Palliative Care;Palliative Medicine;patient population;Patient Representative;Patient-Focused Outcomes;Patients;Periodicals;Physician Executives;Physicians;Plethysmography;Pneumonia;Polysomnography;Population;Prevalence;Provider;Public Health;Pulmonology;Quality of Care;Quality of life;Radio;radio frequency;recruit;Research;Resources;Respiration;respiratory;Respiratory distress;Science;sensor;sensor technology;Sleep;Technology;Testing;tool;United States National Institutes of Health;Universities;Validation;volunteer;Work

PROJECT_TITLE: Detecting respiratory distress in nursing home patients with advanced ADRD using radio sensors

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


NIH_SPENDING_CATS: Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PHR: Project Narrative: The erythropoietic and prothrombotic effects of Erythropoietin in anemic patients implicates the Megakaryocytic- Erythroid progenitor as a direct target, and a useful model to explore mechanisms that uncouple the production of erythroid and platelet-producing megakaryocytic cells. This application describes a small, discrete, well-defined project to identify candidate proteins and target genes that propagate phenotypic and functional changes downstream of Erythropoietin signaling in human hematopoietic progenitors destined to give rise to erythrocytes and platelets. Results from the proposed studies will improve our understanding of the mechanisms of action of Erythropoietin in human bone marrow leading to advancements in treatments for anemia, and will support the lab during transition to independence by generating preliminary data for a future R01 application.

PI_NAMEs: SCANLON, VANESSA M. (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Adult;Affect;Anemia;Apoptotic;Attention;Blood Platelets;Bone Marrow;candidate identification;CD34 gene;cell type;Cells;Chronic;Chronic Kidney Failure;Colony-Forming Units Assay;combat fatigue;cytokine;Cytokine Receptors;Data;Development;dimer;Disparate;effective therapy;EPOR gene;Erythrocytes;Erythroid;Erythroid Cells;Erythropoiesis;Erythropoietin;Erythropoietin Receptor;Flow Cytometry;Foundations;Fracture;Funding;Future;Genes;Genetic Transcription;Hematopoietic;Hematopoietic stem cells;Hour;Human;Hypoxia;Image;Immunophenotyping;improved;Injections;Intervention;Kidney;Knowledge;MAP Kinase Gene;Measures;Mediating;Mediator;Megakaryocytes;mimetics;Modeling;Molecular Mechanisms of Action;Molecular Target;Names;novel;Output;Pathway interactions;Patients;Pharmacologic Substance;Phenotype;PI3K/AKT;polypeptide;Population;Production;progenitor;Proliferating;Proteins;Publishing;receptor;Receptor Activation;Receptor Signaling;Renal function;repaired;Research;response;Risk;Role;self-renewal;Signal Pathway;Signal Transduction;stem cell expansion;stem cell population;Stroke;stroke risk;System;targeted treatment;Testing;thrombocytosis;Thrombopoiesis;Tissues;Transfusion;United States

PROJECT_TITLE: Investigating the Cell Type- and Receptor-Specific Effects of Erythropoietin that Mediate Erythropoiesis and Thrombopoiesis in Primary Human Hematopoietic Progenitor Cells

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Child Abuse and Neglect Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Social Determinants of Health;Violence Research

ORG_CITY: TALLAHASSEE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative Child maltreatment is a serious problem and an estimated 1 in 7 children are maltreated each year. Strong support networks, or safety nets, are a protective factor associated with child abuse prevention, yet we know little about the safety nets of families involved with child protective services. This project has the potential to inform child welfare policy and practice nationwide by determining the effects of safety nets on child permanency and mental health outcomes over time.

PI_NAMEs: MCWEY, LENORE M. (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: Adolescent;Area;Belief;Benefits and Risks;Characteristics;Child;Child Abuse and Neglect;Child abuse prevention;Child Mental Health;child protective service;Child Rearing;Child Welfare;Complement;cost;Data;Effectiveness;evidence base;Excision;Family;family support;foster care;Friends;General Population;Goals;Health;Home;informal support;innovation;Intervention;Lead;Link;longitudinal analysis;Low income;maltreated children;maltreatment;Mental Health;Methodology;Occupations;Outcome;parenting intervention;Parents;Personal Satisfaction;Policies;programs;protective factors;Research;safety net;safety testing;Sampling;service intervention;Services;Social isolation;support network;Surveys;Testing;Time;Training;trend;Work;Youth

PROJECT_TITLE: Parents’ Safety Nets, Child Protective Services Involvement, and Child Outcomes

STUDY_SECTION_NAME: Biobehavioral and Behavioral Sciences Study Section[CHHD-H]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Electronic Nicotine Delivery Systems;Epilepsy;Neurodegenerative;Neurosciences;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

PHR: Project Narrative This project is an important first step in understanding how vaping nicotine and menthol affects neuronal function and seizure susceptibility. Electronic nicotine delivery systems (ENDS) have been marketed as a safer alternative to conventional cigarettes, but there are increasing reports of adverse health effects and seizures associated with their use. This proposal seeks to elucidate the neurobiological consequences of ENDS use by evaluating the propensity for seizure activity and neuronal hyperexcitability.

PI_NAMEs: CAMPBELL, SUSAN LATOYA (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Acute;addiction;Aerosols;Affect;Animals;Area;Astrocytes;Behavioral;Benign;Biological;Body Weight;Brain;Case Study;Cessation of life;Chemical-Induced Change;Chronic;Cigarette;combustible cigarette;Complex;Consumption;Data;Dependence;Development;Devices;Disease;DNA Sequence Alteration;dosage;Electroencephalography;Electronic cigarette;Electronic Nicotine Delivery Systems;Electronics;Electrophysiology (science);Elements;Epilepsy;epileptiform;Etiology;experimental study;Exposure to;Financial Hardship;Flavoring;Foundations;fundamental research;Future;genetic regulatory protein;Glucuronides;Glutamate Transporter;Glutamates;Hand;Health;hippocampal pyramidal neuron;Hippocampus;Homeostasis;Human;In Vitro;Incidence;Individual;individual response;Inhalation;Inhalation Device;Injections;innovation;Investigation;Life;Link;Liquid Chromatography;liquid nicotine;Liquid substance;Location;Long-Term Effects;Marketing;Measures;men;Menthol;Monitor;Motor Activity;Mus;Mutation;Nervous System Disorder;neural;neural circuit;neurobehavioral;Neurobiology;Neurons;Nicotine;nicotine exposure;nicotine inhalation;Nicotinic Receptors;Overdose;Pathogenesis;Pentylenetetrazole;Pharmaceutical Preparations;pharmacologic;Plasma;Policy Maker;postsynaptic;pre-clinical;Predisposition;Prevalence;Proteins;psychologic;Recurrence;Reporting;Research;Research Personnel;response;Rodent;Route;Seizures;Severities;Slice;Smoker;Smoking;Societies;Solvents;System;tandem mass spectrometry;Testing;Toxic effect;toxicant;United States National Institutes of Health;vaping;vaping nicotine;vapor;Youth

PROJECT_TITLE: Electronic nicotine device systems (ENDS)-induced alterations in glutamate homeostasis: Effects on seizure susceptibility

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ORG_CITY: LA JOLLA

ORG_NAME: J. CRAIG VENTER INSTITUTE, INC.

ORG_STATE: CA

PHR: Project Narrative Histoplasma capsulatum, a dimorphic fungal pathogen, is the most common cause of fungal respiratory infections in immunocompetent hosts, and a significant source of morbidity and mortality in immunocompromised patients. Development of inducible/repressible gene expression technologies and improving episomal DNA maintenance in Histoplasma will allow us to generate knockdown and over expression mutants with stable expression levels and phenotypes. These technologies will enable us to characterize putative regulators of host-associated yeast phase of Histoplasma.

PI_NAMEs: BEYHAN, SINEM  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Address;Aspergillus fumigatus;Autonomous Replication;Biological Assay;Body Temperature Changes;Candida albicans;Cell division;Cells;Centromere;Chimeric Proteins;Defect;Development;Disease;DNA;DNA Maintenance;Electroporation;Elements;Ensure;Episome;Escherichia coli;Essential Genes;experience;experimental study;fungus;Gene Expression;gene function;Genes;Genetic;genetic manipulation;Genetic Transcription;Goals;Growth;Health;Heat shock factor;Heat-Shock Proteins 90;Heat-Shock Response;Histoplasma;Histoplasma capsulatum;Histoplasmosis;HSF1;Human;Human body;human disease;Hyphae;Immunocompetent;Immunocompromised Host;improved;In Vitro;in vivo;Individual;Infection;Inhalation;knock-down;Knock-out;Knowledge;Laboratories;Lung;Lung infections;Macrophage;Maintenance;Membrane;Methods;Mississippi;Modeling;Molds;Molecular Chaperones;Morbidity - disease rate;Morphology;mortality;Mus;mutant;Ohio;Organism;overexpression;pathogen;pathogenic fungus;Phase;Phenotype;Plasmids;pleiotropism;programs;Proteins;Repressor Proteins;Reproduction spores;Research;Respiratory Tract Infections;RNA Interference;Role;Saccharomycetales;segregation;Signal Transduction;Soil;Source;System;Systemic infection;Techniques;Technology;telomere;Temperature;Tetanus Helper Peptide;Tetracyclines;Time;tool;Transcription Coactivator;transcription factor;Transcription Repressor;vector;Virulence;Virulence Factors;virulence gene;Work;Yeasts

PROJECT_TITLE: Characterization of Histoplasma transcription factors using improved episomal DNA maintenance and controllable gene expression tools

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: PROJECT NARRATIVE Guillain-Barré Syndrome (GBS) is a form of paralysis initiated by prior infection with Campylobacter jejuni. Antibodies that are induced to target bacterial surface sugars mimicking similar sugars concentrated on our nerves can then cross-react and cause damage and paralysis. We will isolate GBS patient antibodies, inactivate them, and use those antibodies to block further damage and reverse paralysis to create a new GBS treatment.

PI_NAMEs: SZYMANSKI, CHRISTINE M. (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Adaptive Immune System;Affinity;Antibodies;antibody detection;antibody engineering;Antibody titer measurement;Archives;Autoantibodies;B cell repertoire;B-Lymphocytes;bactericide;Bangladesh;Binding;Biological Assay;Biotinylation;Blocking Antibodies;Campylobacter jejuni;Cells;Clinic;Clinical Research;cohort;comparative efficacy;Complement;Complement Membrane Attack Complex;Complex;Cross Reactions;Deposition;Development;Diagnosis;Diarrhea;diarrheal disease;Engineering;Enzyme-Linked Immunosorbent Assay;Excision;Exhibits;foodborne;Ganglioside GM1;Gangliosides;Glycolipids;Goals;Guillain Barré Syndrome;Human;human pluripotent stem cell;IgG1;Immunoglobulin G;Immunoglobulins;in vitro Assay;Individual;Induced pluripotent stem cell derived neurons;Infection;Inflammatory;Intravenous Immunoglobulins;Laboratories;Link;low and middle-income countries;Measures;Medical History;Methods;Modification;Monoclonal Antibodies;Morbidity - disease rate;mortality;mouse model;Muslim religion;Myelin;Nerve;Neurons;novel;Paralysed;Pathogenesis;Pathogenicity;patient derived induced pluripotent stem cells;patient population;Patients;Peripheral;Peripheral Blood Mononuclear Cell;Plasmapheresis;Play;Poliomyelitis;polyclonal antibody;Polysaccharides;Procedures;recruit;Recurrence;Risk;sample fixation;Sampling;Schwann Cells;secondary infection;Serum;Structure;sugar;Surface;Symptoms;Syndrome;Testing;Therapeutic;therapeutic development;therapeutic evaluation;Work

PROJECT_TITLE: Development of ganglioside specific IgGs for the treatment of Guillian-Barré Syndrome

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pediatric

ORG_DEPT: PSYCHOLOGY

ORG_NAME: GEORGIA STATE UNIVERSITY

PHR: PROJECT NARRATIVE Nearly one in five older youth in the United States struggle with basic reading skills, and are consequently placed at a greater risk for unemployment and poor health outcomes compared to their typically developing peers. These persistent reading problems may be due to brain-based difficulties in learning and remembering new words, especially words that sound similar to each other. In the proposed study, we will use non-invasive brain stimulation to test a model of how the brain supports learning and remembering new words in older youth with reading difficulties, which will lay a necessary foundation for future work that will evaluate the potential of non- invasive brain stimulation as an adjunct to treatment in this population.

PI_NAMEs: ARRINGTON, C NIKKI (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: Address;Age;Behavior Therapy;Behavioral;Brain;brain based;causal model;Child;Chronic;design;Development;Disabilities experience;Discrimination;discrimination task;dorsal visual stream;Education;Foundations;Functional Magnetic Resonance Imaging;Future;Growth;Impairment;improved;indexing;Individual;Individual Differences;Language;Language Development;learned behavior;Learning;Learning Difficulty;Left;literacy;Magnetic Resonance Imaging;Measures;Methodology;Modeling;Nature;neural;Neurobiology;neuromechanism;neuroregulation;Noise;noninvasive brain stimulation;novel;Participant;peer;phonology;poor health outcome;Population;Process;Reaction Time;Reader;Reading;reading ability;reading difficulties;Reading Disabilities;repetitive transcranial magnetic stimulation;Reporting;Research;Risk;Role;skills;sound;Structure of supramarginal gyrus;System;Techniques;Testing;Translating;Unemployment;United States;Visual;word learning;Word Processing;Work;Youth

PROJECT_TITLE: Evaluating the Impact of Non-Invasive Brain Stimulation on Learning and Consolidation of Phonologically Similar Novel Spoken Words

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Osteoarthritis;Physical Injury - Accidents and Adverse Effects

ORG_CITY: ITHACA

ORG_DEPT: PHYSICS

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE Osteoarthritis (OA), a disease that affects 30 million people in the United States, is characterized by a progressive degeneration of articular cartilage that is frequently initiated by joint trauma. To gain insight into the response of cartilage cells to injury throughout the tissue, we propose to measure and analyze, using a new large data and machine learning based technique, the real time response of cells throughout a cartilage tissue after it is impacted with an indenter. Understanding how the distribution of cell phenotypes is altered when the tissue is exposed to different impact strengths, or when specific calcium signaling or bioenergetic pathways are enhanced or suppressed will enable us to develop an understanding of the mechanisms that govern cell fate after traumatic injury and ultimately identify targets for interventions that could protect impacted tissue from further degradation.

PI_NAMEs: BONASSAR, LAWRENCE J.;COHEN, ITAI  (contact);DELCO, MICHELLE LEE

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Acute;acute stress;Affect;Animal Model;Apoptosis;articular cartilage;Behavior;Big Data;Big Data Methods;Bioenergetics;Buffers;Calcium;Calcium Signaling;Cartilage;cartilage cell;Cartilage injury;cell behavior;Cell Death;cell injury;Cell Membrane Permeability;Cells;Chondrocytes;Chronic;Clinical;Complex;cost;Data;Data Analyses;Degenerative polyarthritis;Development;disability;Disease;effective therapy;elastography;Event;Exhibits;experience;Exploratory/Developmental Grant;Exposure to;fluorescence imaging;Frequencies;Functional disorder;Future;Genetic Predisposition to Disease;Goals;Heterogeneity;Image Analysis;improved;In Situ;in vivo;Individual;inhibitor;Injury;insight;Intervention;intravital imaging;Ion Channel;joint injury;Location;Machine Learning;Maps;Measurement;Measures;Mechanics;mechanotransduction;Methods;Microscopy;millisecond;Mitochondria;Modeling;Modification;novel;Nuclear;Nuclear Envelope;Pain;Pathogenesis;Pathway interactions;Pattern;Peptides;Permeability;Persons;Phenotype;Physiological;Piezo 1 ion channel;Play;Population;population based;prevent;Process;Production;Reaction Time;Research;response;Role;Secondary to;Signal Pathway;Signal Transduction;single cell analysis;Spatial Distribution;spatiotemporal;Stains;Stress;Structure;supervised learning;Techniques;temporal measurement;Time;tissue injury;Tissues;tool;Trauma;Traumatic Arthropathy;Traumatic injury;United States;Variant;Work

PROJECT_TITLE: Using STRAINS, a big data method that analyzes the spatiotemporal distribution of cell phenotypes, to investigate mechanotransduction pathways in injured cartilage

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Hospitalists provide care to hospitalized patients at most US hospitals. Unfortunately, high burnout and poor mental health of hospitalist clinicians may be associated with increased risk for turnover, which may have high institutional costs as well as negative impacts on patient quality and safety. This work will provide insights into the impact of burnout and poor mental health on hospitalists and the costs associated with turnover and the impact of workloads and work models on these outcomes.

PI_NAMEs: BURDEN, MARISHA  (contact)

PROGRAM_OFFICER_NAME: LIOCE, MARIA

PROJECT_TITLE: The Financial Impact of Burnout and Mental Health on Hospitalist Turnover and the Contribution of Work Structures and Environment

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Research Narrative Although dysbiotic airway microbiome is associated with asthma, our knowledge about the dynamic changes of the airway microbiome and their relationships with asthma exacerbations is limited. This proposed study will characterize the changes of the airway microbiome over time in patients with asthma and identify patterns and taxa that are correlated with asthma exacerbations. The results will fill a knowledge gap in the field of asthma airway microbiome and advance the development of airway bacteria-based asthma therapies.

PI_NAMEs: KRINGS, JAMES ;WANG, LEYAO  (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: 16S ribosomal RNA sequencing;Adult;Adult asthma;Advanced Development;Affect;Age;airway immune response;airway inflammation;Allergens;Antibiotics;Asthma;asthma exacerbation;asthma inhaler;asthmatic patient;Bacteria;bacterial community;Bioinformatics;Biological;case control;Case/Control Studies;Chronic Obstructive Pulmonary Disease;Clinical;Clinical Research;Communities;Cross-Sectional Studies;Data;design;Development;dysbiosis;Electronics;Etiology;Event;Exhibits;feasibility testing;Frequencies;Future;Hemophilus;Hour;Human;Immune response;Immunologic Markers;immunoregulation;Individual;Inhalators;insight;Investigation;Knowledge;Lactobacillus;Longitudinal cohort;Longitudinal cohort study;Longitudinal Studies;Mediating;metagenomic sequencing;microbial;microbial composition;microbiome;microbiome composition;Morbidity - disease rate;new therapeutic target;novel;Participant;pathogenic bacteria;Patients;Pattern;Pharmaceutical Preparations;Population;Research;respiratory microbiome;respiratory microbiota;Role;Sampling;scale up;Seasonal Variations;sensor;sex;Shotguns;Sputum;Streptococcus salivarius;Symptoms;System;Testing;Time;Translational Research;United States;United States Food and Drug Administration;Variant

PROJECT_TITLE: Longitudinal changes of the sputum microbiome in adult asthma and its association with asthma exacerbations

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Digestive Diseases;Genetics;Infectious Diseases;Microbiome

PHR: Project Narrative Bacteria rapidly evolve new capabilities, such as virulence, by acquiring genes from other bacteria through a process called horizontal gene transfer (HGT). HGT occurs by different routes, one of which is the transfer of DNA carried by bacteria infecting viruses (phages) or virus-like agents, known as transduction. This project uses innovations in next-generation DNA sequencing, metagenomics, and metaproteomics to uncover the identity and magnitude of transduced DNA in the microbiota and intestinal pathogens, and is a first step in understanding how transduction of bacteria influences human health.

PI_NAMEs: DUERKOP, BRECK A (contact);KLEINER, MANUEL

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Address;Affect;Antibiotic Resistance;Automation;Automobile Driving;Bacteria;bacterial community;Bacterial DNA;bacteriome;Bacteriophages;Benign;Cells;commensal bacteria;Complex;Data;Detection;Development;Disease;disorder risk;DNA;DNA Sequence;DNA sequencing;Ecosystem;enteric pathogen;Event;Evolution;fitness;Frequencies;Future;Genes;Genetic;Genetic Materials;Goals;gut inflammation;gut microbiome;Health;Horizontal Gene Transfer;Human;human microbiota;in vivo;Inflammatory Bowel Diseases;innovation;Intestinal Diseases;Intestines;Invaded;Investigation;Knowledge;Link;Measurement;Measures;Mediating;member;metagenomic sequencing;Metagenomics;metaproteomics;Methods;microbial;microbial community;microbial genome;microbiome;microbiome therapeutics;microbiota;next generation;novel;novel strategies;novel therapeutics;opportunistic pathogen;particle;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathologic;Pattern;Physiological;Play;Precision therapeutics;prevent;Process;Production;Proteins;reconstruction;resistance gene;Resolution;Role;Route;Sampling;Shapes;Shotguns;success;Taxonomy;Techniques;Time;Toxin;trait;usability;Viral;Virulence;Virus;Virus-like particle;Work

PROJECT_TITLE: DNA transduction in intestinal microbiomes and the spread of pathogenicity traits

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Assistive Technology;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurodegenerative;Neurosciences;Rare Diseases;Rehabilitation

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE  The proposed research is relevant to public health because the proposed structurally suitable neck exoskeleton has the potential to improve care and quality of life for people with head drop resulted from amyotrophic lateral sclerosis. This project is relevant to the part of the NCMRR’s mission that pertains to the development of scientific knowledge needed to enhance health, independence, and quality of life for people with physical disabilities.

PI_NAMEs: ZHANG, HAOHAN  (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: Amyotrophic Lateral Sclerosis;Articular Range of Motion;Breathing;Caregivers;Caring;Chest;Clinical;Clinical Trials;Deformity;Deglutition;design;Development;Devices;Drops;empowerment;evidence base;exoskeleton;Eye;Fatigue;Feedback;Forehead;Frequencies;Future;Goals;Head;Head and neck structure;Head Movements;Health;Home;improved;Individual;Individuals with physical disabilities;innovation;Joints;Knowledge;manufacture;Mechanics;Methods;Mission;Motion;Motor;Movement;Muscle;Neck;Neurodegenerative Disorders;Outcome;Pain;Paralysed;Participant;Patients;Persons;Posture;Process;prototype;Public Health;Published Comment;Quality of life;Reporting;Research;Rotation;Sample Size;satisfaction;Self-Help Devices;Shoulder;Skeletal muscle structure of neck;social;Social Interaction;Spinal;Testing;Time;Translations;Work

PROJECT_TITLE: A structurally suitable neck exoskeleton for amyotrophic lateral sclerosis

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD-K]


NIH_SPENDING_CATS: Microbiome;Nutrition;Obesity

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Overconsumption of fructose-rich food and beverages has emerged as a significant risk factor for the development of obesity, nonalhocholic fatty liver disease and type 2 diabetes. Extensive fructose metabolism in the liver has been shown to contribute to liver lipids accumulation, however, fructose metabolic role in other tissues especially brown adipose tissue is not well understood. Therefore, determining the metabolic impacts of fructose metabolism in brown adipose tissue could shed light on understanding of feeding-induced brown adipocyte energy substrate intake, utilization, and storage.

PI_NAMEs: LIEW, CHONG WEE  (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Acids;Adipocytes;Adipose tissue;antagonist;Antibiotics;Bacteria;Beverages;Bile Acids;blood glucose regulation;Brain;Brown Fat;Chronic;Consumption;Data;design;Diet;dietary;Duodenum;Fatty acid glycerol esters;fatty liver disease;feeding;Female;Food;Fructose;Functional disorder;Glucose;Glycogen;gut microbiome;Hepatocyte;Homeostasis;Human;Impairment;In Vitro;in vivo;Incubated;insight;Intake;Isotopes;Kidney;knock-down;Lipids;Liver;Liver X Receptor;male;Mediating;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;microbial;microbiome;microbiota;microbiota composition;Mus;Mutant Strains Mice;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity development;Organ;overexpression;Play;prevent;Regulation;Risk Factors;Rodent;Role;Serum;Skeletal Muscle;small hairpin RNA;Small Intestines;sugar;Testing;Time;Tissues;Tracer;transcriptome;Transplantation;Up-Regulation;Weight Gain

PROJECT_TITLE: Brown adipose tissue fructose metabolism

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Aging;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: CINCINNATI

ORG_NAME: MOGLING BIO INC

PHR: NARRATIVE Aging of blood forming stem cells can cause anemia, immune deficiency and hematologic malignancies in older adults. We will develop a first-in-class regimen by inhibition of the small GTPase Cdc42 in aged human blood stem cells with a small molecule in a closed circuit stem cell manipulation apparatus. The product will be applicable to aged bone marrow transplant patients to rejuvenate the declined function of their aged blood stem cells to benefit the lives of older adults.

PI_NAMEs: MULLOY, JAMES C (contact);ZHENG, YI

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Age;age related;age related biomarkers;aged;Aging;aging biomarker;aging related;Anemia;animal old age;Animals;Attenuated;Autologous;Autologous Transplantation;Biological Markers;Biological Process;Blood;Blood Cells;bone aging;Bone Marrow;Bone Marrow Cells;Bone Marrow Transplantation;Cell Polarity;Cells;Chemistry;Chronology;Clinical;clinical application;Clinical Trials;clinically relevant;commercialization;Consensus;Data;Devices;Dose;drug candidate;Dysmyelopoietic Syndromes;Elderly;Engraftment;epigenetic clock;Erythrocytes;functional decline;Future;Goals;Hematologic Neoplasms;Hematopoiesis;hematopoietic stem cell aging;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hematopoietic System;Human;Immune;immune function;Immune response;Immune system;immunodeficiency;improved;in vivo;Incidence;inhibitor;Intervention;Lead;lead candidate;lead optimization;leukemia;Leukocytes;life span;Lymphoid;Medical Device;Molecular;Monomeric GTP-Binding Proteins;mouse model;Mus;Myelogenous;Myeloproliferative disease;novel;older adult;Output;patient response;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;prevent;Production;Protocols documentation;Publishing;Regimen;Rejuvenation;response;restoration;retransplantation;rho GTP-Binding Proteins;Siblings;Signal Transduction;Small Business Innovation Research Grant;small molecule;small molecule inhibitor;stem cell aging;stem cell biomarkers;stem cell engraftment;Stem cell transplant;stem cells;Structure;Syndrome;System;Technology;Testing;Therapeutic;Therapeutic Intervention;Transplant Recipients;Transplantation;Treatment Protocols;Vaccination;Xenograft procedure

PROJECT_TITLE: Pharmacological rejuvenation of human hematopoietic stem cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-V (10)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: NARRATIVE The goal of this proposal is to provide talented students from underrepresented populations formative experiences and training that will contribute to their scientific development and guide them towards successful careers in the biomedical workforce. To achieve this goal, we will recruit outstanding underrepresented minority students and subsidize their tuition, wages, and housing costs for the Summer Program in Neuroscience (SPIN) at Boston University School of Medicine, an existing summer program that integrates mentored neuroscience research with small group graduate-and medical level neuroscience education, and exposure to clinical activities focused on the diagnosis and treatment of brain disease. Graduates of our program have mentioned it has been a life changing experience that has motivated them to pursue careers in science and medicine; we expect that SPIN will provide positive and motivating experiences for underrepresented minority students, and help to increase the numbers of underrepresented minorities in the biomedical workforce.

PI_NAMEs: HOLSAPPLE, JAMES W;RUSHMORE, RICHARD JARRETT (contact);WISCO, JONATHAN J.

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Academia;Basic Science;Boston;Brain;Brain Diseases;brain research;Brain scan;brass;career;Career Choice;career development;Climacteric;Clinic;Clinical;cohort;Communities;community building;cost;Degree program;Development;Diagnosis;digital;Disease;Dissection;Education;education planning;Educational Curriculum;Educational process of instructing;Elements;Enrollment;Evaluation;experience;Exposure to;Faculty;Feedback;Funding;Future;Goals;Graduate Education;graduate school;hands on instruction;Health;Historically Black Colleges and Universities;Hospitals;Hour;Housing;Human;improved;inpatient service;Inpatients;Institution;Instruction;interest;Interview;Knowledge;Laboratories;laurencin;Learning;Magnetic Resonance Imaging;Measures;Medical;Medical Education;medical schools;Medicine;member;Mentors;Microscopic;Minority Groups;Modeling;Neuroanatomy;Neurology;Neurosciences;Neurosciences Research;neurosurgery;Operating Rooms;Oral;Outcome;outpatient programs;Participant;Physicians;Population;programs;radiological imaging;recruit;Recruitment Activity;Reproducibility;Research;Research Project Grants;Resources;Rotation;Scholarship;Science;Science, Technology, Engineering and Mathematics;Scientist;skill acquisition;skills;STEM career;Structure;Student recruitment;Students;success;summer program;symposium;Talents;Time;Training;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;Underrepresented Students;Universities;Wages;working group

PROJECT_TITLE: Enhancing Diversity in the Summer Program in Neuroscience at Boston University

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-D (27)]