NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Parkinson's Disease

PHR: Narrative Alzheimer disease (AD) and Parkinson disease (PD) are heterogeneous, multifactorial disease that selectively affects certain regions of the brain. In this proposal, we will use our established in vitro and in vivo mouse experimental systems and the cutting-edge technologies of spatial transcriptomics and scRNA-seq to systematically evaluate ten candidate TF in regulating astrocyte activation their roles in AD and PD pathogenesis. These TFs are excellent candidate targets for the development of effective AD or PD treatment strategies.

PI_NAMEs: MUSIEK, ERIK STEVEN;ZHAO, GUOYAN  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;amyloid pathology;Animal Model;Animals;Anterior;Astrocytes;Autopsy;Brain;Brain region;brain tissue;Cell Line;cell type;Cells;Central Nervous System;Cerebellum;chemokine;cingulate cortex;Cognitive;Corpus striatum structure;cytokine;Data;Dementia with Lewy Bodies;Development;differential expression;Disease;Disease susceptibility;entorhinal cortex;Exhibits;Funding;Future;Gene Expression;gene function;Genes;Genetic Markers;Grant;Growth;Hippocampus;Homeostasis;Human;human disease;human induced pluripotent stem cells;In Vitro;in vivo;Individual;Inflammatory Response;interdisciplinary collaboration;Investigation;knock-down;Laboratories;Link;Measures;Morphology;mouse model;Mus;Nerve Degeneration;neural circuit;Neurodegenerative Disorders;Neuroglia;neuron loss;Neurons;novel;novel therapeutic intervention;overexpression analysis;Parkinson Disease;Parkinson's Dementia;Pathogenesis;Pathology;Pattern;Phagocytosis;Play;Population;Prefrontal Cortex;Prevention;Process;Property;Publishing;regional difference;response to injury;risk variant;Role;single nucleus RNA-sequencing;single-cell RNA sequencing;Slice;stem cell model;Substantia nigra structure;System;Tauopathies;Technology;Therapeutic Intervention;therapeutically effective;transcription factor;Transcriptional Regulation;transcriptome;transcriptomics;treatment strategy;United States National Institutes of Health;Work

PROJECT_TITLE: Evaluating novel transcription factors in regulating astrocyte identity, reactivity, and their roles in neurodegenerative disease pathogenesis

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_FIPS: US

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: Project Narrative MicroRNAs are a very particular type of RNA molecules that can regulate many cellular processes at once - including the cell’s pathological processes – and have been understudied because common genomics tool do not usually detect them. Here we serendipitously discovered that one of these microRNAs was very abundant in the neurons most vulnerable to Alzheimer’s disease, and we propose to demonstrate that it is used by vulnerable neurons to keep pathological tau in check, before it goes down as the disease unfolds. We propose to define its mode of action and investigate if it could represent a good therapeutic target for early stages of Alzheimer’s disease.

PI_NAMEs: ROUSSARIE, JEAN-PIERRE  (contact)

PROJECT_TERMS: Aging;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Amyloid beta-Protein;amyloid pathology;Amyloidosis;arm;Cell Physiology;cell type;Cells;Code;Data;Deposition;differential expression;Disease;Down-Regulation;entorhinal cortex;gene discovery;Genes;Genetic Predisposition to Disease;genomic tools;Histology;Human;human induced pluripotent stem cells;improved;in silico;In Situ Hybridization;In Vitro;in vivo;Individual;insight;Intervention;Knock-in Mouse;Knock-out;Knockout Mice;Link;Maps;Measures;Messenger RNA;Microglia;MicroRNAs;Modeling;Monitor;mouse model;Mus;Mutation;Nerve Degeneration;neurofibrillary tangle formation;Neurons;novel therapeutics;old mice;overexpression;Pathogenesis;Pathogenicity;Pathologic;Pathologic Processes;Pathology;Pathway Analysis;Pathway interactions;Pattern;Play;Population;posttranscriptional;pre-clinical;Predisposition;prodromal Alzheimer's disease;Proteins;Regulation;Resistance;ribosome profiling;Risk;RNA;RNA Splicing;RNA Stability;Role;single nucleus RNA-sequencing;Surveys;tau aggregation;tau Proteins;Tauopathies;Testing;Therapeutic;therapeutic target;Untranslated RNA

PROJECT_TITLE: Regulation of entorhinal cortex layer II vulnerability by a cell-type specific miRNA

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

PHR: Project Narrative For reasons that are still unknown, Alzheimer’s Disease only affects, in its earliest stages, neurons involved in new memory formation. The molecular events that are taking place around these neurons before the first symptoms even occur, and that determine the entire course of the disease are not known, and it is therefore challenging to design drugs to block early stages of neurodegeneration. Here we propose to use cutting-edge genomics and proteomics technologies to fully describe the molecular events taking place when pathological proteins start to aggregate in the most vulnerable region of the brain.

PROJECT_TERMS: Affect;Age;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Amyloid deposition;Appearance;Area;Autopsy;Biological Markers;Brain;Brain region;Candidate Disease Gene;Catalogs;Cell Nucleus;cell type;Cells;Clinical;cohort;combinatorial;Data Set;design;Development;differential expression;Disease;Disease Resistance;Dissection;Drug Design;Early identification;endophenotype;entorhinal cortex;Event;follow-up;frontal lobe;Future;Gene Expression;gene network;Genes;Genetic Markers;Genetic Transcription;genome-wide;Genomics;Hippocampus;Human;Immunofluorescence Immunologic;Immunoprecipitation;in silico;In Situ Hybridization;indexing;Individual;individual variation;Inflammation;insight;Lesion;Maps;Mass Spectrum Analysis;Measurement;Memory;Memory Loss;Methods;Modeling;Molecular;Molecular Profiling;multimodality;Mus;Neocortex;Nerve Degeneration;network dysfunction;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuroglia;neuronal excitability;Neurons;neuropathology;novel;Participant;Pathogenesis;Pathologic;Pathology;Pathway interactions;Peptides;Phosphorylation;Phosphorylation Site;Plasma;Prefrontal Cortex;prodromal Alzheimer's disease;Protein Isoforms;Proteins;Proteomics;Reelin Signaling Pathway;Rest;RNA Splicing;Sampling;single cell genomics;single nucleus RNA-sequencing;Symptoms;System;tau aggregation;tau Proteins;tau-1;Techniques;Technology;Testing;Therapeutic;Therapeutic Intervention;transcriptome sequencing;transcriptomics;Tropism;Validation;virtual;Work

PROJECT_TITLE: Identification of early transcriptional and pathological changes undergone by vulnerable brain regions during prodromal Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Q (55)]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Lung;Precision Medicine

ORG_CITY: CHAPEL HILL

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Individuals with cough hypersensitivity syndrome suffer from many medical complications including broken ribs, unintended urine leakage, and fainting. It is necessary to understand the mechanisms underlying cough hypersensitivity syndrome to guide clinical decision making and improve treatment outcomes. The long-term goal of this work is to develop improved diagnostics and interventions for cough hypersensitivity syndrome.

PI_NAMEs: NOVALESKI, CAROLYN K. (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: acceptability and feasibility;Accidents;Address;Adult;Anxiety;Area;Asthma;Behavior Therapy;Behavioral;burden of illness;career development;Chronic;Chronic Disease;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Clinical;clinical decision-making;clinical phenotype;clinical practice;Clinical Research;Clinical Skills;Clinical Trials;Cognitive;Coughing;Data;Diagnostic;Disease;Distress;experience;Extravasation;Foundations;Frequencies;Future;Goals;Health;high risk;Human;Hypersensitivity;improved;improved outcome;Individual;individual patient;Injections;Intake;Intervention;Investigation;Label;Language;Lead;Leadership;Life;logarithm;Loneliness;Lung;Lung Diseases;Measurable;medical complication;Mental Depression;Mentored Patient-Oriented Research Career Development Award;Mission;National Heart, Lung, and Blood Institute;Nerve Block;Neurobiology;neuroregulation;Nonpharmacologic Therapy;observational cohort study;Outcome;Pathologist;patient oriented research;patient subsets;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;predicting response;Prediction of Response to Therapy;programs;prospective;Psychology;psychosocial;Qualifying;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;Research;Research Design;Research Priority;respiratory;Respiratory Signs and Symptoms;response;rib bone structure;Sensory;Site;Speech;Speech Therapy;standard of care;Stimulus;Strategic vision;Subgroup;Symptom Burden;symptomatic improvement;Symptoms;Syncope;Syndrome;targeted treatment;Testing;Time;Training;treatment optimization;Treatment outcome;treatment response;United States;Urine;Work

PROJECT_TITLE: Identifying Predictors of Treatment Response to Pharmacologic and Nonpharmacologic Interventions in Cough Hypersensitivity Syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-O (M3)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: PALO ALTO

ORG_NAME: PALO ALTO VETERANS INSTIT FOR RESEARCH

ORG_STATE: CA

PHR: PROJECT NARRATIVE Pakistan is the fifth most populous country in the world and more than 63% of all marital unions in Pakistan are consanguineous, posing a greater impact on genetically transmitted diseases like Alzheimer’s Disease and Related Dementia, which has never been systematically studied before. This feasibility study will collect genetic and phenotypic data from a consanguineous sample from Pakistan that is verified and harmonized by the NIA- funded cores to provide basis for pursuing subsequent NIA funding under the “ADSP Follow-Up Study (FUS) 2.0: The Diverse Population Initiative''.

PI_NAMEs: ADAMSON, MAHEEN MAUSOOF (contact)

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TERMS: Accounting;Affect;Age;Aging;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;American;Architecture;Award;Blood;Blood specimen;Caucasians;cell repository;China;Cognitive;cognitive testing;cohort;Collection;combat;Communities;Consanguinity;Consensus;Consent Forms;Country;Data;data acquisition;Data Collection;data harmonization;Data Storage and Retrieval;data storage site;Dementia;Developing Countries;Diagnosis;Diagnostic;disease transmission;Elderly;Ensure;Ethnic Origin;European;exome;experience;Feasibility Studies;Female;Floods;Follow-Up Studies;Funding;Genetic;Genetic Research;Genome;Genomics;Genotype;Goals;Growth;Hand;human old age (65+);Income;India;Individual;Infrastructure;instrument;International;Knowledge;Learning;Light;low and middle-income countries;Magnetic Resonance Imaging;Medical;Middle Eastern;National Institute on Aging;neuroimaging;North African;Pakistan;Participant;Patients;peri-urban;Persons;Phenotype;phenotypic data;Pilot Projects;Population;Population Heterogeneity;Preparation;Process;Protocols documentation;Province;Race;Research;Research Personnel;Resources;Sampling;Secure;sex;Shipping;Site;South Asian;Training;Translating;United States;United States National Institutes of Health;Universities

PROJECT_TITLE: Leveraging Consanguinity in Pakistan to Uncover the Genomic Architecture of Alzheimer's Disease: Feasibility Study with ENIGMA-PAK

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Social Determinants of Health;Substance Misuse

ORG_CITY: Columbus

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative This study examines the relationship between disasters and adverse substance use outcomes, both of which have increased dramatically over the past several decades with no signs of abating. This study uses quasi- experimental methods and longitudinal and spatial modeling to determine whether disasters have affected substance use outcomes, including through mechanisms such as psychological distress and treatment and drug market disruption, by combining data from the Centers for Disease Control and Prevention, the National Survey on Drug Use and Health, the FBI Uniform Crime Reports, and an underutilized dataset of all disaster declarations from the Federal Emergency Management Agency (FEMA). By examining these mechanisms as well as analyses by key aggregate- and individual-level sociodemographic characteristics, this project has the potential to improve morbidity and mortality by informing how resources and individual- and community-level interventions may be deployed to intervene on drug-related problems in the face of future disasters.

PI_NAMEs: VUOLO, MICHAEL C (contact)

PROGRAM_OFFICER_NAME: DEPADILLA, LARA MIREILLE

PROJECT_TERMS: Abate;Adult;adverse outcome;Affect;anthropogenesis;Area;Back;Black Populations;Censuses;Centers for Disease Control and Prevention (U.S.);Cessation of life;Characteristics;climate change;Communities;community intervention;County;Crime;Data;Data Set;Databases;demographics;Dependence;Diffuse;Dimensions;Disasters;Disease;Distress;Droughts;Drug Addiction;drug market;Drug usage;Earthquakes;Education;Emergency Situation;Equity;Ethnic Origin;Event;experience;Exposure to;extreme weather;Fentanyl;Floods;Frequencies;Future;Gender;Geography;Growth;Health;health disparity;heroin use;Human;Hurricane;improved;Individual;instrument;Latinx population;Life;Life Expectancy;Link;Literature;Low income;Marketing;Mental disorders;Mental Health;Meta-Analysis;misuse of prescription only drugs;Modeling;Morbidity - disease rate;mortality;Nature;novel;Outcome;Overdose;overdose death;Pattern;Persons;Pharmaceutical Preparations;physical conditioning;population health;Process;psychological distress;Public Health;public health research;Quasi-experiment;Race;Reporting;Research;Research Personnel;research study;Resources;Role;rurality;Sampling;sex;Shock;social group;social health determinants;sociodemographics;socioeconomics;Stimulant;substance use;Suicide;Surveys;synthetic opioid;Testing;theories;treatment services;Urbanicity;vehicular accident;years of life lost

PROJECT_TITLE: Direct and Indirect Effects of Disasters on Drug-Related Outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 LXF-E (M1)]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Congenital Heart Disease;Heart Disease;Orphan Drug;Pediatric;Pediatric Cardiomyopathy;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will define a new and important role for a common protein in the pathogenesis of heart disease. This could have far-reaching implications in the development of therapies for genetic diseases of the heart. Thus, the proposed research is relevant to part of the NIH’s mission as it will seek basic discoveries relating to the cause of disease with applicability and potential for translation to clinical practice.

PI_NAMEs: ELEZABY, ALY  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Adenosine Triphosphate;Affect;Amino Acid Substitution;ATP phosphohydrolase;Attenuated;Automobile Driving;Award;Binding;Biochemistry;Biology;C-terminal;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiovascular Diseases;Cardiovascular system;career development;Cause of Death;Cells;Clinical;clinical practice;Communication;Complement;Computer Models;Data;design;Development;Development Plans;Dilated Cardiomyopathy;Disease;Drug Design;drug development;Education;Engineering;enzyme activity;Functional disorder;Genetic;Genetic Diseases;genetic variant;Genotype;Goals;Heart;Heart Diseases;Heart failure;heart function;Heart Injuries;heart metabolism;Human;Human Engineering;human induced pluripotent stem cells;Hypertrophic Cardiomyopathy;Impairment;improved;In Vitro;in vitro activity;in vivo;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;inherited cardiomyopathy;inhibitor;ischemic injury;Kinetics;Lead;Mentors;Mentorship;mimetics;Mission;Mitochondria;mitochondrial dysfunction;Mitochondrial Matrix;Modeling;mouse model;Muscle Cells;Mutation;Myocardial Infarction;N-terminal;new therapeutic target;novel;Pathogenesis;Pathogenicity;Pathologic;Patients;Peptides;Phenotype;Phosphorylation;Phosphorylation Inhibition;Physiology;prevent;Probability;programs;protein complex;protein kinase C-delta;Proteins;Proteolysis;Proton-Translocating ATPases;Public Health;Rattus;Recombinants;Relaxation;Research;Respiration;Restrictive Cardiomyopathy;Role;Scientist;Signal Transduction;skills;stem cell biology;Structural Protein;Structure;Sudden Death;targeted treatment;Testing;Therapeutic;therapeutic target;Therapeutically Targetable;therapy development;Training;Transgenic Mice;translational potential;Troponin I;United States National Institutes of Health;Variant;Ventricular Remodeling

PROJECT_TITLE: Moonlighting in Mitochondria: A Non-Canonical Role for Cardiac Troponin I in Inherited Cardiomyopathies

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (MA)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biomedical Imaging;Chronic Obstructive Pulmonary Disease;Lung;Prevention

ORG_CITY: IOWA CITY

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Narrative This study will characterize unique subtypes of COPD-related abnormalities in airway and chest wall deformation between two lung volumes, identify their associations in COPD and comorbidities, and assess their impacts on disease progression and clinical outcomes. This project will leverage established datasets from nationwide longitudinal lung studies and deliver chest CT-based automated metrics of lung volume-determined airway and chest wall deformation, normative models, computation of standardized scores of alterations in airway and chest wall metrics, and characterization of unique airway and chest wall subtypes in COPD.

PI_NAMEs: COMELLAS, ALEJANDRO PIERRE;SAHA, PUNAM K. (contact)

PROGRAM_OFFICER_NAME: HU, TOM CHIH-CHUANG

PROJECT_TERMS: Affect;Age;Air;Air Movements;Airway Resistance;Area;Automation;Bone Density;Breathing;Chest;chest computed tomography;Chest wall structure;Chronic Obstructive Pulmonary Disease;Clinical;clinically relevant;Cluster Analysis;Collection;comorbidity;Compression Fracture;Computing Methodologies;cone-beam computed tomography;Data;data repository;Data Set;demographics;Dimensions;Disease Progression;Elasticity;Ethnic Origin;Fatty acid glycerol esters;Functional disorder;genetic epidemiology;Geometry;Goals;Height;Hospitalization;Impairment;Individual;Inspiratory Capacity;Lobar;Lung;lung volume;mechanical properties;Mechanical ventilation;Mechanics;Methods;Modeling;mortality;Multi-Ethnic Study of Atherosclerosis;multidisciplinary;Muscle;never smoker;Non-linear Models;novel;Osteoporosis;Outcome;Participant;Pathway interactions;Pattern;Pectoral;Physical activity;Pulmonary Emphysema;pulmonary function;radiological imaging;Research;research study;Residual state;Respiration;Respiratory System;rib bone structure;sarcopenia;Severity of illness;sex;small airways disease;Smoking;Smoking History;Smoking Status;Spinal Fractures;spine bone structure;Standardization;Thinness;Thoracic cavity structure;Thoracic Diseases;translational study;Validation;Vertebral column;Walking;Weight;X-Ray Computed Tomography

PROJECT_TITLE: CT-based Characterization of Lung Volume-determined Airway and Chest Wall Deformation Interdependences in COPD

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE The proposed research holds significant relevance to public health as it aims to develop a groundbreaking non- invasive MRI imaging technique. This technique will assess changes in membrane lipid properties in Alzheimer's disease, revolutionizing the current approach by providing a novel perspective on AD pathology and potentially enabling early diagnosis.

PI_NAMEs: ZU, ZHONGLIANG  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: 3-Dimensional;Abeta synthesis;Address;Age;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease model;Alzheimer's disease pathology;Amyloid beta-Protein;amyloid precursor protein processing;Animal Disease Models;Animal Model;Animals;Assessment tool;Biochemical;Biology;Brain;Brain imaging;Cell membrane;Cell Physiology;Cells;Cellular Structures;Chemicals;Cholesterol;Chromatography;clinical imaging;contrast enhanced;Coupling;Cultured Cells;Data Correlations;Data Set;Dependence;Development;Diagnosis;Diagnostic;Disease;Early Diagnosis;experimental study;fluidity;Fluorescence;Goals;human imaging;Image;Image Enhancement;imaging modality;Imaging Techniques;improved;innovation;insight;ionization;Lecithin;Length;Link;Lipids;Longitudinal Studies;Magnetic Resonance Imaging;Maps;mass spectrometric imaging;Mass Spectrum Analysis;Measurement;Measures;Membrane;Membrane Fluidity;Membrane Lipids;Methods;Molecular;Monitor;Mus;non-invasive imaging;novel;novel therapeutic intervention;nuclear Overhauser enhancement;Performance;Phosphatidylethanolamine;Phospholipids;physical property;Play;potential biomarker;Property;Public Health;reconstitution;reconstruction;Research;Research Personnel;Resolution;response;Role;Sampling;Series;Signal Transduction;Slice;tandem mass spectrometry;Techniques;theories;Therapeutic;Tissue Extracts;Tissues;tool;Variant

PROJECT_TITLE: Development of an innovative Non-Invasive MR Imaging Technique for assessing Membrane Lipids and Their Properties in Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-U (80)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Women's Health Research

ORG_DEPT: BIOLOGY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Narrative NEXMIF is a novel X-linked ASD gene and an increasing number of female individuals with NEXMIF haploinsufficiency have been reported to demonstrate autistic symptoms. In the brain, neurons lacking NEXMIF proteins contain a normal copy of the NEXMIF gene which is inactivated due to its localization in the silenced X-chromosome. We therefore propose to reactivate the dormant Nexmif copy by X chromosome reactivation, and to determine whether the potential therapeutic reagents are able to rescue the cellular defects and behavioral abnormalities in female heterozygous mice.

PI_NAMEs: MAN, HENGYE  (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Adopted;autism spectrum disorder;autism symptoms;autistic behaviour;Behavior;Behavioral;behavioral impairment;Biochemical;Biological;Brain;Chemicals;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;Compensation;Defect;design;Diagnosis;Drug Compounding;efficacy evaluation;Encephalopathies;Equilibrium;Female;Foundations;Future;Gene Dosage;Genes;Genetic;Growth;Heterozygote;Impairment;In Vitro;in vivo;Individual;inhibitor;Injections;Intellectual functioning disability;Intervention;Knock-out;Knockout Mice;Learning;Link;male;Mammalian Cell;Measures;member;Memory;Messenger RNA;Methyl-CpG-Binding Protein 2;migration;Molecular;Morphology;mosaic;Mosaicism;mouse model;Mus;Nature;Neurodevelopmental Disorder;Neurologic;Neurons;novel;Null Lymphocytes;Patients;Phenotype;PI3K/AKT;Population;Process;Promoter Regions;Proteins;Reagent;repetitive behavior;Reporting;Research;restoration;RNA;RNA-Binding Proteins;Role;Seizures;sex;Site;small hairpin RNA;small molecule;small molecule inhibitor;social;Social Behavior;Social Interaction;Specificity;Synapses;synaptogenesis;Techniques;Therapeutic;Therapeutic Studies;Transcription Coactivator;Viral;Virus;Visual;Western Blotting;women patients;X Chromosome;X Inactivation

PROJECT_TITLE: Exploring the Rescue Strategy for Female NEXMIF Haploinsufficiency via X Chromosome Reactivation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-P (57)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: Project Narrative To address the challenge of demand for ADRD care outpacing supply, we propose a novel modeling approach, macro-simulation, to simultaneously account for supply and demand factors. Using the family as a decision-making unit, the model describes the tradeoffs families face when using a combination of formal and informal care to meet the needs of their elderly members. This analytical tool will shed light on the aggregate consequences of growing care needs and widening care shortages and how targeted policy interventions may help.

PI_NAMEs: WANG, JUE  (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Address;Adult Children;Affect;Age;Aging;aging population;Alzheimer's Disease;Alzheimer's disease care;Alzheimer's disease patient;Alzheimer's disease related dementia;American;analytical tool;Calibration;care giving burden;care systems;Caregivers;caregiving;Caring;Cognitive;cognitive function;Communities;cost;cost effective;Data;Data Set;Data Sources;Decision Making;dementia care;dementia caregiving;design;Discipline;Economics;Elderly;Eligibility Determination;Environment;Equilibrium;Exercise;Exhibits;experience;Face;Family;Family Caregiver;family caregiving;Family Process;Family Relationship;family structure;Feedback;flexibility;functional decline;Goals;Government;Growth;Health;Health and Retirement Study;Heterogeneity;Home;Household;human old age (65+);Impaired cognition;Individual;informal care;insight;Intervention;Knowledge;Life;Literature;Long-Term Care;Long-Term Care for Elderly;Marketing;Medicine;member;Modeling;models and simulation;Nature;novel;Outcome;panel study of income dynamics;Personal Satisfaction;Persons;Policies;Policy Maker;Population;preference;Price;Production;Public Policy;Resources;Rest;Retirement;Sampling;Savings;Services;simulation;Sleep;Societies;socioeconomics;Sociology;Structural Models;Structure;Surveys;System;Time;trend;United States;Wages;welfare

PROJECT_TITLE: A Family-Based Macro-simulation Model on the Supply and Demand of Care for ADRD

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Gene Therapy;Genetics;Immunotherapy;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: MADISON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative  Despite revolutionizing the treatment of hematological malignancies, chimeric antigen receptor (CAR) T cell therapy has had limited efficacy against solid tumors including pediatric neuroblastoma, which is associated with a dismal prognosis upon recurrence. To overcome the molecular and cellular mechanisms that limit the efficacy of CAR T cells against neuroblastoma, we will use targeted radionuclide therapies that selectively deliver low dose radiation to all tumors throughout a patient’s body to stimulate infiltration and activation of CAR T cells in these sites. We expect that this project will provide the preclinical data needed to justify clinical studies that will test the safety and efficacy of combining for the first-time targeted radionuclide therapy and CAR T cells for treatment of children with neuroblastoma and potentially any type of cancer.

PI_NAMEs: SODJI, QUAOVI H (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: antitumor effect;Apoptosis;cancer cell;cancer immunotherapy;cancer therapy;cancer type;CAR T cell therapy;Cell Death;Cell Death Induction;Cell Line;Cell Therapy;Cells;Cephalic;Cessation of life;Chemicals;Chemistry;Child;Childhood;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clinical Research;Clinical Trials;Combined Modality Therapy;culture plates;cytotoxic;cytotoxic CD8 T cells;cytotoxicity;Data;Discipline of Nuclear Medicine;Disease;Doctor of Philosophy;Dose;dosimetry;drug discovery;effector T cell;efficacy evaluation;engineered T cells;Engineering;Evaluation;exhaustion;Exposure to;External Beam Radiation Therapy;Goals;Hematologic Neoplasms;Hematopoietic Neoplasms;Human;immune cell infiltrate;Immune mediated destruction;Immunocompetent;Immunogenetics;improved;in vivo;indexing;Infiltration;Inflammatory Response;irradiation;K-Series Research Career Programs;Label;Laboratories;Link;Low Dose Radiation;Lutetium;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;medical schools;member;Memory;Mentors;Mentorship;Modeling;Molecular;mouse model;Mus;MYCN gene;neoplastic cell;Neuroblastoma;neuroblastoma cell;novel;Oncology;Patients;Penetration;Pharmaceutical Preparations;pre-clinical;Predisposition;professor;Prognosis;Proteomics;Public Health;Radiation;Radiation Chimera;Radiation Dose Unit;Radiation Oncology;Radiation therapy;Radioactive;Radiobiology;Radiochemistry;Radioisotopes;Radionuclide therapy;receptor;Recurrence;Relapse;Research;response;Role;safety testing;Site;Solid;Solid Neoplasm;success;Surface Antigens;Survival Rate;symposium;synergism;T cell infiltration;T-Cell Receptor Therapy;tenure track;Testing;Therapeutic;Time;TNFSF10 gene;Training;Training Activity;translational potential;translational research program;tumor;tumor eradication;tumor growth;tumor immunology;tumor microenvironment;Universities;vector;Wisconsin;Xenograft Model

PROJECT_TITLE: Targeted Radionuclide Therapy to Enhance the Efficacy of CAR T Cells Against Neuroblastoma

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Peripheral neuropathies, characterized by sensory and motor dysfunction, are a major clinical problem and can be a consequence of genetic disorders, metabolic diseases, environmental stressors, or injury. Due to a lack of direct treatment options patients with peripheral neuropathies are often prescribed medications to treat symptoms (e.g. pain medication), that do not promote nerve repair, highlighting a limited understanding of how peripheral nerve plasticity is induced and maintained. In this application, we will investigate new cellular mechanisms governing Schwann cell plasticity in an effort to identify novel therapeutic targets for the treatment of nerve injury.

PI_NAMEs: DABOUSSI, LYDIA  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Address;Adhesions;Affect;Analgesics;Animals;antagonist;Area;Axon;axon injury;axon regeneration;axonal sprouting;Behavior;Biological Assay;cell motility;Cell Reprogramming;Cells;ChIP-seq;Clinical;Complex;CRISPR/Cas technology;Data;Defect;design;Detection;Development;Disease;disease model;Drug Prescriptions;Electron Microscopy;environmental stressor;Epithelial Cells;epithelial to mesenchymal transition;experience;experimental study;flexibility;Gene Expression;Gene Expression Regulation;gene-editing approach;Generations;Genes;Genetic;Genetic Diseases;Genetic Transcription;Goals;Grant;Growth;Immune system;In Vitro;Individual;Injury;Ligands;Luciferases;MAP Kinase Gene;Mediating;medical specialties;Mentors;Metabolic Diseases;Metabolism;metaplastic cell transformation;Modeling;Molecular;Morphology;Motility;Motor;motor disorder;Mus;mutant;Mutant Strains Mice;myelination;Natural regeneration;Nerve Degeneration;nerve injury;Nerve Regeneration;nerve repair;Nervous System Trauma;Neuroglia;neuronal survival;Neurons;new therapeutic target;NF-kappa B;pain sensitivity;Pathologic;Pathway interactions;Patients;peripheral nerve regeneration;Peripheral Nerves;Peripheral Nervous System;Peripheral Nervous System Diseases;Phagocytes;Pharmaceutical Preparations;Phenotype;Play;Predisposition;preservation;Process;programs;Proliferating;Property;receptor;Recovery;Regulation;reinnervation;repaired;RNA;Role;scaffold;Schwann Cells;sciatic nerve injury;Sensorimotor functions;Sensory;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;symptom treatment;Symptoms;System;Techniques;Testing;therapeutic target;Tissues;tool;Training;Transcript;transcription factor;transcriptomics;transdifferentiation;Transforming Growth Factor beta;Up-Regulation;Viral;Viral Vector;Virus;Wnt proteins;WNT Signaling Pathway

PROJECT_TITLE: WNT Mediated Induction of Schwann Cell Plasticity

STUDY_SECTION: NST

STUDY_SECTION_NAME: Neurological Sciences Training 3 Study Section[NST-3]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Diabetes;Dissemination and Implementation Research;Health Services;Rural Health;Social Determinants of Health

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE The utilization of Diabetes Self-Management Education and Support (DSMES) services is low, despite their proven benefits to patients. This study aims to understand factors associated with low utilization of DSMES and to identify potential DSMES provider opinion leaders by: (1) exploring the association of demographic, health status, provider availability, rural and urban residence status, and DSMES program density with DSMES participation at the patient-level by leveraging claims data from the Arkansas All-Payer Claims Database for Medicare, Medicare Advantage and privately insured patients; (2) constructing patient-sharing networks of providers who care for patients with type 2 diabetes (T2D) and applying social network analysis to determine whether patient-sharing relationships among providers is associated with DSMES participation; and (3) identifying the potential agents of change (i.e., opinion leaders) through self-designating surveys of providers. Delineating the social network of T2D providers yields the preliminary data needed to design effective interventions that can expand DSMES referral networks and enhance patient care.

PI_NAMEs: REZAEIAHARI, MANDANA  (contact)

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: Address;Adopted;Adoption;Adult;aged;Arkansas;Awareness;Behavior;Behavioral;Blindness;burden of illness;Cardiovascular Diseases;care providers;career;Caring;Cause of Death;Characteristics;Clinical;Collaborations;Communication;Complex;cost effectiveness;Data;Data Analytics;Databases;density;design;diabetes education;diabetes management;Diabetes Mellitus;diabetes self-management;Diagnosis;Diffusion;Diffusion of Innovation;Education;effective intervention;Eligibility Determination;Enrollment;Exercise;Foundations;Funding;Glycosylated hemoglobin A;Goals;Health Insurance;Health Professional;Health Status;human old age (65+);improved;Individual;Influentials;innovation;Insurance;insurance claims;Intervention;Kidney Failure;Knowledge;Lead;Leadership;limb amputation;Logistic Regressions;Logistics;Lower Extremity;Measures;Medical;Medicare;Medicare claim;member;Mentors;Methodology;Methods;Modeling;multidisciplinary;network models;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Pathway Analysis;Patient Care;Patient-Focused Outcomes;patient-level barriers;Patients;Pattern;Pharmaceutical Preparations;Physicians;Population;population health;Positioning Attribute;Prevalence;Privatization;Productivity;programs;Provider;provider networks;provider-level barriers;psychologic;Public Health;Regression Analysis;Research;Research Personnel;Research Project Grants;Role;Rural;rural residence;Science;Services;social;Social Network;Statistical Methods;statistics;stress management;Stroke;Structure;Surveys;System;systematic review;Testing;theories;tool;Training;Translational Research;uptake;urban residence;Variant

PROJECT_TITLE: Understanding Utilization of Diabetes Self-Management Education and Support Using Social Network Analysis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE  The project by Dr. Mertens and colleagues aims at deciphering the interface of age-related pathways and genetic risk for mild cognitive impairment (MCI) and Alzheimer's disease (AD) using patient-specific induced neurons (iNs). The team will study the underlying molecular structures of MCI using unbiased multi-omic approaches in MCI and AD patient-derived iNs, and compare them to healthily aging control iNs. They will further employ targeted experiments to study the role of neuronal functionality as a convergence platform for aging and disease, and they will leverage insights from their multi-layered characterizations to explore novel approaches to treat MCI and AD.

PI_NAMEs: MERTENS, JEROME S. (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: 3-Dimensional;Adult;Affect;Age;age acceleration;age related;Aging;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-Protein;Animals;Astrocytes;Autopsy;Binding;biological age;Biological Aging;Biological Models;Brain;Buffers;Calcium;Cell Aging;Cells;cellular pathology;Characteristics;ChIP-seq;clinically relevant;Coculture Techniques;cohort;Complement;Data;Data Set;Dementia;Detection;Development;Disease;Disease Pathway;Disease Progression;DNA Binding;DNA Damage;Early identification;Elderly;Electrophysiology (science);Environment;epidemiologic data;epigenetic aging;Epigenetic Process;epigenomics;Ethology;Etiology;Event;experimental study;Feedback;Fibroblasts;Functional disorder;Genes;Genetic;genetic makeup;Genetic Risk;Genetic Transcription;genotyped patients;Goals;healthy aging;Human;human old age (65+);Image;Impaired cognition;Induced Neurons;induced pluripotent stem cell;insight;interest;Intervention;Investigation;Malignant Neoplasms;Metabolic;metabolomics;Microglia;mild cognitive impairment;Modeling;Molecular;molecular phenotype;Molecular Structure;multi-electrode arrays;multiple omics;Nerve Degeneration;Neuroglia;neuronal patterning;Neurons;novel strategies;novel therapeutic intervention;older adult;patch clamp;Pathogenesis;Pathologic;pathological aging;Pathway interactions;Patients;Pattern;Persons;Phenotype;Physiological;preservation;Proteomics;rate of aging;response;Risk;Risk Factors;risk variant;Role;single-cell RNA sequencing;Symptoms;Synapses;tau-1;Testing;Therapeutic;therapeutic development;transcriptomic profiling;transcriptomics;Validation;Work

PROJECT_TITLE: Age-equivalent neurons from MCI patients to investigate early determinants of AD


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Biomedical Imaging;Chronic Pain;Clinical Research;Osteoarthritis;Pain Research;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Multidisciplinary teams investigating a multifactorial disease process like osteoarthritis is a logical and necessary approach for innovative break-throughs in clinical practice. This award will allow the PI to expand his mentoring of young researchers, junior faculty, postdocs, and PhD students in lower extremity biomechanics and leverage the rich clinical environment at UCSF to open new inroads in clinical research.

PI_NAMEs: SOUZA, RICHARD BRIAN (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Acceleration;Accelerometer;adduct;Age;Anatomy;Anterior;Area;Award;Biomechanics;biomedical imaging;Body mass index;bone;bone metabolism;Bone remodeling;Bone Spur;bone visualization;California;career;Cartilage;Clinical;clinical practice;Clinical Research;cohort;Communities;Custom;Data;Degenerative polyarthritis;design;Development;Devices;disability;Disease;Disease Progression;doctoral student;driving force;Educational process of instructing;Environment;Evaluation;Exercise;Faculty;Fatty acid glycerol esters;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;Functional disorder;Funding;Goals;Hip Osteoarthritis;Hip region structure;Image;imaging approach;imaging modality;imaging study;Inflammation;Infrastructure;innovation;interest;joint biomechanics;joint loading;Joints;Kinetics;Knee;Knee bone;Knee joint;Knee Osteoarthritis;knee pain;Leg;Linear Models;Link;Lower Extremity;Magnetic Resonance Imaging;Maps;Measurement;Measures;mechanical load;Mechanics;Medial;Meniscus structure of joint;Mentors;Metabolic;Methods;Midcareer Investigator Award in Patient-Oriented Research;moderate-to-vigorous physical activity;Monitor;Motion;multidisciplinary;Musculoskeletal;Musculoskeletal Pain;novel;Pain;Pain Free;Pain intensity;patellar tendon;pathomechanics;patient oriented research;Patient Recruitments;Patients;Performance;Peripheral;Persons;Physical activity;Physical Rehabilitation;Physical therapy;Population;Positron-Emission Tomography;Postdoctoral Fellow;primary outcome;Process;Productivity;professor;programs;quadriceps muscle;quantitative imaging;radiological imaging;rehabilitation science;Relaxation;Reproducibility;Request for Applications;Research;Research Personnel;Roentgen Rays;Sampling;San Francisco;Scientist;Series;sex;Source;Standardization;Structural defect;subchondral bone;Symptoms;Synovial Membrane;System;Thigh structure;Time;Tissues;Tracer;Training;Universities;uptake;Wages;Weight-Bearing state;Work

PROJECT_TITLE: Mentoring Biomechanics Research in Osteoarthritis

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: SARASOTA

ORG_NAME: ROSKAMP INSTITUTE, INC.

ORG_STATE: FL

PHR: Small brain bleed and swelling termed amyloid-related imaging abnormalities (ARIA’s) are adverse effects of recent FDA approved aducanumab antibody used for AD, and this occurs more frequently in patients carrying the APOE4 gene. In this study we will use a previously described mouse AD model expressing human APOE isoforms to interrogate the contribution of activated microglia to APOE4 mediated ARIA following aducanumab treatment. We will generate a detailed time-course of functional, pathological and gene level changes to the cerebrovasculature, and reveal novel targets that can reduce the risk of ARIA in APOE4 carriers receiving anti-A? ?  antibody therapies.

PI_NAMEs: OJO, JOSEPH O (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Ablation;Acceleration;Acute;Aducanumab;Adverse effects;adverse event risk;Alleles;Alzheimer's disease model;Amyloid;Amyloid beta-Protein;amyloid pathology;Antibodies;Antibody Therapy;Antigen-Antibody Complex;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Autoantibodies;Automobile Driving;Autopsy;Biochemical;Blood - brain barrier anatomy;Blood Vessels;Brain;cell injury;cell type;Cells;Cerebral Amyloid Angiopathy;Cerebral small vessel disease;cerebrovascular;Cerebrovascular Circulation;cerebrovascular lesion;cerebrovascular reactivity;Cerebrovascular system;Cerebrum;Chronic;Clinical Trials;cognitive function;cognitive testing;comorbidity;Complement;demented;Dose;Drainage procedure;Edema;Elderly;Event;Excision;FDA approved;Frequencies;Genes;genome wide association study;Genotype;glial activation;Gliosis;Goals;Hemorrhage;high risk;Human;Hypercapnia;Image;Impairment;improved;in vivo;Individual;Infiltration;Inflammation;Inflammatory;innovation;Investigation;Lesion;Link;lipid metabolism;lipid transport;Macrophage;Measurement;Mediating;Metabolism;Microglia;Modeling;Molecular;mouse model;Mus;Mutation;Myeloid Cells;Nerve Degeneration;Neuronal Dysfunction;neurovascular injury;Newborn Infant;novel;Outcome;Pathologic;Pathway interactions;patient population;Patients;Pericytes;Phenotype;Play;Population;Positron-Emission Tomography;Pre-Clinical Model;Primates;Protein Isoforms;Proteomics;Recurrence;release factor;Research Design;response;Risk Factors;Risk Reduction;Role;Severities;single-cell RNA sequencing;Site;Swelling;Techniques;Time;transcriptomics;vascular inflammation;Withdrawing Treatments;Work

PROJECT_TITLE: Influence of microglial cell depletion and repopulation on aducanumab induced ARIA and vascular lesions in APOE4 carriers with AD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-B (55)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative Obesity is a major risk factor for neurodegenerative diseases like Alzheimer’s disease (AD). However, how obesity increases the likelihood of developing AD remains unclear. We have now a lead that we will investigate with the goal of reducing the severity and the incidence of AD and other dementia in obese patients, and with that reduce the burden of AD on patients, their caregivers, and society.

PI_NAMEs: O'ROURKE, EYLEEN JORGELINA (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: abeta accumulation;Acceleration;Adult;aggregation factor;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's Disease Pathway;Alzheimer's disease risk;Attenuated;Award;Behavioral;beta amyloid pathology;Biological Assay;Biological Models;Biology;Brain;Caenorhabditis elegans;Caregivers;Cells;Cellular Membrane;Charge;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Cultured Cells;Dementia;Diabetes Mellitus;Diet;diet-induced obesity;Disease;Dose;early onset;Future;Genes;Genetic;Genetic Screening;Genetic Transcription;Goals;Human;human disease;Hypertension;Image;Impaired cognition;in vivo;Incidence;Individual;insight;Insulin Resistance;Insulin Signaling Pathway;Intervention;Knock-out;Knowledge;Lead;Link;loss of function mutation;Mammals;Measurable;Mediating;Mitochondria;Modeling;Molecular;Motor;mouse model;Mus;Names;Nerve Degeneration;Neurodegenerative Disorders;Neurologic;Neurology;Neurons;obese patients;Obesity;obesogenic;Orthologous Gene;Output;Pathway interactions;Patients;pharmacologic;Phase;Phenotype;Prevalence;Prevention;Principal Investigator;protein aggregation;Proteins;proteostasis loss;proteotoxicity;Reporter;Reporting;Research;Risk Factors;RNA Interference;RNA interference screen;Role;Science;Severities;Signaling Molecule;single-cell RNA sequencing;Societies;Testing;therapeutic target;Thinness;transcription factor;transcriptome;Transgenic Organisms

PROJECT_TITLE: Molecularly Dissecting How Obesity-Promoting Diets Activate the Neuronal Protein Aggregation Factor MOAG-4/SERF2

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE Natural Killer (NK) cells are crucial for antiviral defense and require stimulation via cytokines through STAT transcription factors to exert their function. Multiple cytokines activate STAT3 in NK cells which is involved in immune disorders and is regularly mutated in malignancies including NK cell derived lymphoma. The goal of this study is to dissect how STAT3 influences NK cell function in a new model of viral infection that shows a context-dependent role of STAT3 in NK cells.

PI_NAMEs: GRASSMANN, SIMON  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: adaptive immunity;Advisory Committees;Antigens;antiviral immunity;ATAC-seq;Binding;Biology;Cancer Biology;cancer therapy;career;career development;CD8-Positive T-Lymphocytes;Cell Differentiation process;Cell Physiology;Cells;Cleavage Under Targets and Release Using Nuclease;clinical translation;Clonal Expansion;Computational Biology;cytokine;Cytokine Signaling;Cytomegalovirus Infections;Data;Disease;Dose;Enhancers;Environment;Epigenetic Process;experimental study;gain of function mutation;gene repression;Genetic Transcription;Genomics;Goals;Histones;Human;human morbidity;human mortality;Immune;Immune Evasion;Immune system;Immune System Diseases;Immunology;immunopathology;Immunoprecipitation;Impairment;In Vitro;Infection;inhibitor;Innate Immune System;insight;Institution;interest;Interferon alpha;Interleukin-10;Knowledge;Lead;loss of function;Lymphoma;Malignant - descriptor;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;meetings;Memorial Sloan-Kettering Cancer Center;Mentors;Mentorship;Methods;Modeling;Molecular;mouse model;Murid herpesvirus 1;Mutate;Mutation;Natural Immunity;Natural Killer Cells;novel;Pattern;permissiveness;Phase;Play;Positioning Attribute;Postdoctoral Fellow;programs;Proliferating;promoter;protein protein interaction;receptor;Research;response;Role;RUNX3 gene;Scientist;Senior Scientist;Shapes;Signal Transduction;skills;Specificity;STAT1 gene;STAT2 gene;STAT3 gene;STAT4 gene;Stat5 protein;Technical Expertise;Technology;Testing;Time;transcription factor;tumor;Universities;Viral;Viral Physiology;Virus;Virus Diseases;Work

PROJECT_TITLE: Investigating the molecular basis of context-dependent STAT3 function in NK cells

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Clinical Research;Immunization;Immunotherapy;Infectious Diseases;Organ Transplantation;Prevention;Transplantation

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative Fungal diseases are on the rise, and one of them, cryptococcosis, causes devastating meningoencephalitis in immunosuppressed individuals, including organ transplant recipients. There are no biomarkers to detect risk or early stages of disease in individuals on immunosuppressive drugs. This project is designed to discover antibody biomarkers to identify those at risk for disease.

PI_NAMEs: YOON, HYUN AH  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Adult;Alabama;anti-fungal agents;Antibodies;Antibody Formation;antibody-dependent cell cytotoxicity;Antibody-mediated protection;antigen test;Applications Grants;B Cell Proliferation;beta-Glucans;Binding;biobank;Biological Markers;Biometry;Blood;career;career development;CD4 Lymphocyte Count;Cell Wall;Cells;Child;Clinical;Clinical assessments;Clinical Data;clinical investigation;Clinical Research;Clinical Trials;cognitive testing;cohort;Collaborations;comorbidity;comparison control;Cryptococcosis;Cryptococcus;Cryptococcus neoformans;Cryptococcus neoformans infection;Data;Dedications;demographics;design;Development;Development Plans;Diagnosis;diagnostic biomarker;Disease;Disease Outcome;disease prognosis;Disease Progression;disorder risk;dosage;Dose;Early Diagnosis;Early treatment;Economically Deprived Population;Encapsulated;Enrollment;Epidemiology;European Organization for Research and Treatment of Cancer;Exhibits;experience;Extramural Activities;Fostering;Funding;Fungal Components;glucuronoxylomannan;Goals;Growth;health care availability;high risk;HIV;HIV Seronegativity;HIV Seropositivity;human study;Iatrogenesis;Immune response;Immunocompromised Host;Immunoglobulins;Immunology;immunosuppressed;Immunosuppression;Immunosuppressive Agents;In Vitro;Individual;Infection;International;Kidney Transplantation;Knowledge;Laboratories;laminaran;Link;Logistic Regressions;Longitudinal Studies;longitudinal, prospective study;Lymphocyte Count;Master of Science;Measures;Mediating;Medical center;Meningoencephalitis;Mentors;Mentorship;Modeling;Monitor;Morbidity - disease rate;mortality;Mus;mycophenolate mofetil;natural antibodies;Neurological status;Onset of illness;Organ Preservation;organ transplant recipient;Outcome;Participant;pathogen;Pathogenesis;patient oriented research;patient population;Patients;Persons;Phagocytosis;Pharmaceutical Preparations;Phase;Physicians;Plasma;Polysaccharides;Positioning Attribute;prognostic;Prognostic Marker;prospective;Prospective Studies;Publishing;recruit;Research;Research Design;Research Methodology;Research Project Grants;Research Training;response;Risk;Risk Assessment;Risk Factors;Risk Marker;risk stratification;Role;Sampling;Scientist;skills;socioeconomic disadvantage;Sodium Glutamate;Solid;Steroids;symposium;T-Cell Activation;T-Lymphocyte;Techniques;Testing;Therapeutic;Time;Training;Translational Research;United States National Institutes of Health;Universities;Virulence Factors

PROJECT_TITLE: Antibody Biomarkers of Cryptococcosis in Immunosuppressed Solid Organ Transplant Recipients

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Research Study Section[MID]


ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE Cancer immunotherapy using patient’s own engineered immune cells has shown dramatic cures in some leukemias and lymphomas. But every patient, like their cancer, is unique, and immunotherapies built using an individual patient’s cells are highly variable from one patient to another. The proposed research will focus on identifying the degree of functional variability across patients in engineered cellular immune therapies, and if successful will ultimately enable predictive diagnostic testing to personalize cell therapies to individual patients.

PI_NAMEs: ROTH, THEODORE LEE (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Advisory Committees;Antigen Receptors;assay development;Autoimmune;Behavior;Biological Assay;cancer immunotherapy;Cancer Patient;CAR T cell therapy;career;career development;Cell Compartmentation;Cell Physiology;Cell Therapy;Cells;cellular engineering;Cellular immunotherapy;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clinical Trials;cohort;Communities;Complement;cost;Data;Data Set;diagnostic assay;diagnostic strategy;Diagnostic tests;Doctor of Philosophy;effective therapy;engineered T cells;Engineering;Ensure;Environment;FDA approved;Foundations;Funding;Future;Gene Targeting;Genetic;Genotype;Goals;Heme;high dimensionality;Immune;immune checkpoint blockade;Immune system;immunoengineering;Immunotherapy;In Vitro;in vivo;individual patient;K-Series Research Career Programs;Knock-in;leukemia/lymphoma;Libraries;Liquid substance;Malignant Neoplasms;Measurement;Mentors;Metadata;Methodology;Modeling;Modification;Molecular;multidisciplinary;Mutation;Nature;Oncology;Pathologist;Pathology;patient response;patient variability;Patients;Performance;personalized strategies;Phase;Phenotype;Physicians;pre-clinical;programs;Publishing;rapid test;Relapse;Research;Residencies;resistance mechanism;Running;Scientist;screening;side effect;Solid Neoplasm;success;Surface;System;T cell therapy;T-Lymphocyte;Technology;Testing;Therapeutic;Training;tumor;Tumor Cell Line;Universities;Work;Xenograft Model

PROJECT_TITLE: Dissecting intrinsic variability in engineered T Cell immunotherapies


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Infertility;Nutrition;Obesity;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: This proposal will examine the impact of obesity on the human endometrium from a well-phenotyped cohort of reproductive-aged women. We will utilize single nuclear RNA sequencing, high-resolution mass-spectrometry, functional assays of endometrial decidualization, and multiple measures of adiposity to better understand how obesity alters the endometrium. Results from this study may aid in identification of novel biomarkers and will help stimulate additional studies to inform clinical practice and counseling for women with obesity and infertility.

PI_NAMEs: HAMMOUD, SAHER SUE;SCHON, SAMANTHA BETH (contact)

PROGRAM_OFFICER_NAME: DEYAMPERT, TARA LYNN

PROJECT_TERMS: adipokines;Adult;Affect;aged;Anatomy;Anovulation;Automobile Driving;Biological Assay;Body mass index;Categories;Cell model;Cells;Chronic Disease;Clinical;clinical practice;Clinical Research;cohort;Complex;Counseling;Data;Data Set;Decidual Cell Reactions;Defect;diminished ovarian reserve;Disease;disease heterogeneity;early pregnancy loss;Endocrine System Diseases;Endometrial;Endometrium;Exhibits;experimental study;Female;Functional disorder;Genetic Transcription;Glean;Heterogeneity;High Risk Woman;Hormonal;Human;Hypothalamic structure;implantation;Individual;Infertility;innovation;insight;Irregular Menstruation;Link;liquid chromatography mass spectrometry;Luteal Phase;male;Mass Spectrum Analysis;Measures;men;Metabolic;Metabolic Diseases;Molecular;Morbid Obesity;mouse model;multidisciplinary;novel;novel marker;Nuclear;Nuclear RNA;Obesity;Oocytes;Ovary;Pathologic;Pathology;Pathway interactions;Phenotype;Pituitary Gland;Play;Population;Pregnancy;Pregnancy Rate;Procedures;Process;proliferative phase Menstrual cycle;protein expression;Proteome;proteomic signature;Proteomics;Public Health;recruit;Reproduction;reproductive;reproductive axis;Reproductive system;Resolution;Risk;RNA;Rodent Model;Sampling;senescence;single nucleus RNA-sequencing;Spontaneous abortion;Testing;Tissues;transcriptome;transcriptome sequencing;transcriptomics;Transplantation;Uterus;Validation;validation studies;Variant;Weight;Woman;Women's study;Work

PROJECT_TITLE: Investigating obesity and adiposity-induced alterations to the human endometrium

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-C (02)]


ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Relevance: The brain shows marked plasticity across a variety of learning and memory tasks as well as during recovery after injury. This proposal aims to investigate targeted stimulation of cortex to drive cortical plasticity and induce functional recovery via state-of-the-art electrophysiology and optogenetics to simultaneously record and manipulate activity of sensorimotor neurons in awake behaving macaques. Understanding the role of these basic physiological phenomena will shed light on underlying mechanisms of brain plasticity that leads to functional reorganization in the brain and can provide us with vital insight to develop stimulation-based therapies for a broad range of neurological disorders such as stroke.

PI_NAMEs: YAZDAN SHAHMORAD, AZADEH  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Area;awake;Behavioral;Brain;design;Disease;Effectiveness;Electrophysiology (science);Engineering;injury recovery;insight;ischemic lesion;Learning;Macaca;Maps;Measures;Memory;Motor Cortex;Nervous System Disorder;neural;neurological rehabilitation;Neuronal Plasticity;Neurons;novel;optogenetics;Pattern;Physiological;Recovery of Function;Rehabilitation therapy;Role;sensorimotor system;Solid;Somatosensory Cortex;Stroke;tool

PROJECT_TITLE: Engineering neuroplasticity using volitional control of activity-dependent optogenetic stimulation in macaque sensorimotor cortex


NIH_SPENDING_CATS: Brain Disorders;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative  The proposed research will utilize mitochondrial transfer to rescue motor neuron-related mitochondrial dysfunction in spinal bulbar muscular atrophy (SBMA), an X-linked neuromuscular disorder. The goals of the proposed research are to identify new biomarkers for SBMA and to establish the rationale and validate the feasibility to harness neural stem cells as an efficient mitochondrial supplier to treat disease motor neurons. This work will help establish a clinically translatable platform for human induced pluripotent stem cell-based therapeutic intervention for SBMA and other related neurodegenerative and neurologic disorders.

PI_NAMEs: FENG, XIA  (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Androgen Receptor;Attenuated;Biologic Characteristic;Biological;Biological Assay;Biological Markers;biomarker identification;CAG repeat;Cell Line;cell type;Cells;Cellular Structures;clinical translation;Disease;effective therapy;Elements;Exhibits;extracellular vesicles;Future;gain of function;Genetic;Goals;Growth;Human;human disease;human induced pluripotent stem cells;Impairment;injured;innovation;Intervention;Knock-out;Ligands;Link;loss of function;Mediating;Mitochondria;mitochondrial dysfunction;motor neuron degeneration;Motor Neuron Disease;Motor Neurons;Muscular Atrophy;mutant;Nerve Degeneration;nerve stem cell;Nervous System Disorder;Neurites;Neurodegenerative Disorders;Neuromuscular Diseases;Neuronal Differentiation;Neuronal Injury;Neurons;neuroregulation;novel;novel marker;Pathogenesis;Pathogenicity;Pathologic;Pathology;Physiological;Property;protein phosphatase inhibitor-2;Reactive Oxygen Species;Recovery;Regenerative Medicine;Research;Research Personnel;Respiration;restoration;Specific qualifier value;spinal and bulbar muscular atrophy;stem cell model;stem cell therapy;targeted treatment;Therapeutic;Therapeutic Intervention;therapeutic target;Transplantation;uptake;Vesicle;Work

PROJECT_TITLE: Mitochondrial Transfer to Treat SBMA Motor Neurons


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: The prefrontal cortex is the part of the brain that hold our cognitive abilities, and it is thought to communicate with our visual system to produce attention towards visual information important for our current needs. In this proposal, we will study the nature of this communication to understand how we choose to attend to discrete aspects of our surroundings. With a thorough understanding of the underlying neuronal mechanisms, we can begin to understand how this communication malfunctions, and attention falls short, in disorders like attention deficit hyperactivity disorder (ADHD) and Schizophrenia.

PI_NAMEs: AEHRLUND RICHTER, SOFIE  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Anatomy;Animals;Anterior;Area;Attention;Attention deficit hyperactivity disorder;Award;Axon;Behavior;Behavioral;Brain;cellular targeting;cingulate cortex;Cognition;cognitive ability;Cognitive Science;Communication;Complex;Computing Methodologies;Data;Disease;Feedback;Future;Goals;Image;insight;Literature;Maps;Mentorship;Modality;Morphology;Mus;Nature;neural;Neurons;neurophysiology;novel;Optics;optogenetics;Output;Pathway interactions;Phase;Physiological;Physiology;Population;Population Analysis;Positioning Attribute;Prefrontal Cortex;Property;Publishing;recruit;Research;Research Personnel;Rewards;Schizophrenia;Sensory;Source;Structure;Techniques;Technology;Testing;tool;Training;two photon microscopy;two-photon;Viral;Vision;Vision Disorders;Visual;Visual attention;Visual Cortex;visual information;Visual Perception;visual processing;visual stimulus;Visual System;Work

PROJECT_TITLE: Dissecting distinct contributions of different Prefrontal subregions on goal-directed visual attention

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (03)]


NIH_SPENDING_CATS: Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE We have discovered that inhibition of angiotensin-converting enzyme (ACE) in the brain can counteract the rewarding effect of fentanyl. The goal of this proposal is to develop new ways to inhibit ACE that are more selective and specific to its function in the brain, which may lead to new treatments for opioid use disorders.

PI_NAMEs: MORE, SWATI S;ROTHWELL, PATRICK  (contact)

PROGRAM_OFFICER_NAME: HILLERY, PAUL

PROJECT_TERMS: Angiotensin-Converting Enzyme Inhibitors;Angiotensins;Behavioral;Biological Assay;Blood - brain barrier anatomy;Brain;brain tissue;Catalytic Domain;Cells;Chemicals;Collaborations;Data;Dissociation;Dopamine Receptor;Drug Delivery Systems;endogenous opioids;Enzyme Inhibition;experimental study;extracellular;Fentanyl;fentanyl exposure;fentanyl self-administration;Genetic;Glutamates;Goals;improved;Intravenous;Liquid Chromatography;Measures;Methionine Enkephalin;Mus;N Domain;National Institute of Drug Abuse;Neurons;novel;novel therapeutic intervention;Nucleus Accumbens;Opioid;opioid use disorder;patch clamp;Peptidyl-Dipeptidase A;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Principal Investigator;Prodrugs;Property;Publishing;Recombinant Proteins;Rewards;Schedule;Self Administration;Signal Transduction;Synaptic Transmission;System;tandem mass spectrometry;Therapeutic;Tissues

PROJECT_TITLE: Domain-specific inhibition of angiotensin-converting enzyme as a therapeutic strategy for opioid use disorders


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Epilepsy;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Patient Safety;Precision Medicine

PHR: Project Narrative Existing methods of predicting response to surgical treatment based on patient's clinical and imaging characteristics are inadequate for guiding personalized treatment of pharmacoresistant epilepsy and ameliorating its high burden in adults and children. This proposal uses advanced analytic methods with a novel network-based approach to derive predictors of outcomes from non-invasive and accessible functional brain images. The results of this proposal will guide future studies and advance the field toward developing biomarkers, predicting response to treatment, and understanding the disease mechanisms in epilepsy.

PI_NAMEs: GHOLIPOUR, TAHA  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Accounting;Address;Adult;advanced analytics;Advisory Committees;Advocate;analytical method;arm;Benchmarking;Biological Markers;Board Certification;Brain;Brain imaging;Brain region;Characteristics;Child;Childhood;Classification;Clinical;clinical application;clinical care;Clinical Data;clinical database;clinical decision-making;clinical imaging;Collection;comparative trial;Complement;connectome;Contralateral;cost;Data;Data Set;design;Disease;Distant;Epilepsy;Episodic memory;Evaluation;Excision;experience;Freedom;Functional Imaging;Functional Magnetic Resonance Imaging;functional outcomes;Future;Goals;Growth;heterogenous data;Human;Image;Image Analysis;Imaging Device;Impaired cognition;improved;improved outcome;in vivo;Individual;individual patient;innovation;Institution;Intractable Epilepsy;Investigation;Knowledge;Lesion;Machine Learning;machine learning method;Magnetic Resonance Imaging;Maps;Masks;Measures;medial temporal lobe;Memory Loss;Mentors;Methods;Morbidity - disease rate;mortality;National Institute of Neurological Disorders and Stroke;network architecture;Network-based;Neurocognitive;neuroimaging;Neurologist;Neuropsychology;Neurosciences;novel;Operative Surgical Procedures;Outcome;outcome prediction;Partial Epilepsies;patient oriented;Patients;Pattern;personalized care;personalized medicine;Persons;predicting response;Prediction of Response to Therapy;predictive modeling;Predictive Value;prevent;prospective;Recurrence;Reporting;Research;Research Personnel;Research Training;Resected;Rest;Risk;Scientist;Seizures;Selection for Treatments;Site;statistical and machine learning;statistics;surgery outcome;Temporal Lobe;Temporal Lobe Epilepsy;Time;tool;Training;Translating;Treatment outcome;treatment response;Validation

PROJECT_TITLE: Predicting epilepsy surgery outcomes from individualized resting state functional anomalies

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE The underlying mechanisms of the health disparity by which African Americans are more prone to develop AD are significantly understudied. In this vein, this hypothesis-testing and -generating proposal will provide more definitive relationships between African American-associated APOE variants and AD-related phenotypes.

PI_NAMEs: BRAFMAN, DAVID A (contact)

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TERMS: Acceleration;Address;Adult;Affect;African American;African American population;African ancestry;Aging;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-Protein;Animal Model;Apolipoprotein E;Astrocytes;Biochemical;Biomedical Engineering;Black Populations;Cell Line;Cells;Data;design;Development;Disease;disease model;Disease Progression;Ensure;Epigenetic Process;European ancestry;experience;Future;Gene Frequency;gene-editing approach;Generations;Genetic;genetic analysis;genetic risk factor;Genetic Transcription;genetic variant;genome editing;genome wide association study;Genotype;health disparity;high risk;Human Engineering;human induced pluripotent stem cells;hyperphosphorylated tau;Individual;Investigation;Karyotype;Mediating;Methods;Microglia;Minor;Modeling;Molecular;molecular targeted therapies;Mutation;Neurodegenerative Disorders;Neurons;non-demented;Not Hispanic or Latino;Onset of illness;Pathologic;Pathway interactions;Patients;Phenotype;pluripotency;Population;Probability;Process;Protein Isoforms;Reporter;Reporting;Risk;Risk Factors;Role;Series;Signal Pathway;stem cell model;stem cells;System;Testing;uptake;Variant;Veins

PROJECT_TITLE: Investigating an African American-specific APOE genetic variant using hiPSC

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Q (55)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: This proposal seeks to use human-induced pluripotent stem cell (hiPSC)-based models to elucidate the relationship between APOE isoforms, biological sex, and AD risk. This research will significantly advance our understanding of the complex genetic interactions that modulate AD onset and age-related progression.

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Address;age related;Alleles;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-Protein;Animal Model;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Astrocytes;Biochemical;Biological;biological sex;Cell Line;cell type;Cells;Cognitive;combinatorial;Complex;Data;design;Disease;Environment;familial Alzheimer disease;Female;Future;gene editing technology;Gene Frequency;gene-editing approach;Generations;Genes;Genetic;genetic risk factor;Genetic Transcription;genome editing;Genotype;genotypic sex;High Prevalence;human induced pluripotent stem cells;hyperphosphorylated tau;in vivo;Individual;Inflammatory;insight;Investigation;Klinefelter's Syndrome;Life;Link;male;men;Methods;Microglia;Modeling;Molecular;molecular targeted therapies;mosaic;Mutation;Nature;neural;Neurons;neuroprotection;Onset of illness;Pathologic;Patients;Phenotype;Play;Ploidies;Probability;Protein Isoforms;Reporting;Research;Resources;response;Risk;Risk Factors;Role;sex;Sex Chromosomes;Sex Differences;Signal Pathway;stem cell model;Stimulus;System;tau-1;Testing;Therapeutic Intervention;Time;uptake;Variant;Woman;women patients;Work

PROJECT_TITLE: Dissecting the interaction between sex and APOE genotype in modulating AD risk

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome;Prevention

ORG_CITY: BALTIMORE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Post-operative atrial fibrillation (poAF) is the most common complication following cardiac surgery (~30%), and patients who experience poAF are more likely to suffer a number of adverse outcomes, including longer stays in the ICU and increased mortality. To improve patient outcomes, we propose to collect left atrial tissue from patients who are in normal sinus rhythm as they undergo cardiac surgery, and then identify gene-expression and epigenomic differences in this tissue between patients that subsequently do and do not develop poAF. We will then perform a functional validation of variants causing these changes in cardiac muscle stem cells. Successful completion of this study will identify new pharmacological targets for preventing and treating poAF, potentially improving the lives of millions of patients.

PI_NAMEs: MUEHLSCHLEGEL, JOCHEN DANIEL (contact);STRANGER, BARBARA E

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: adverse outcome;Aorta;Atrial Fibrillation;Biological;Calcium;Cardiac;Cardiac Myocytes;Cardiac Surgery procedures;Cells;Chronic Kidney Failure;Clinical;Closure by clamp;Code;cohort;comorbidity;Complication;CRISPR/Cas technology;Development;Disease;Disease susceptibility;DNA;DNA Methylation;DNA Sequence;Environment;Epigenetic Process;epigenomics;European;Exhibits;experience;experimental study;Gene Expression;Gene Expression Profile;Genetic;Genetic Predisposition to Disease;Genetic Transcription;genetic variant;Genetic Variation;Genomics;Genotype;Heart Atrium;Hospitals;Human;human old age (65+);Hypertension;Image;improved;improved outcome;Individual;induced pluripotent stem cell;insight;Ischemia;Knowledge;Left;Left atrial structure;Length of Stay;Maps;Methodology;Methylation;methylation pattern;methylome;Molecular;mortality;muscle progenitor cell;Mutation;Myocardium;novel;Obesity;Operative Surgical Procedures;Optics;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;pharmacologic;Physiological;Postoperative Period;Predisposition;prevent;Prevention;Quantitative Trait Loci;Research;response;RNA;Sampling;Sinus;Specificity;Stress;stroke risk;Testing;Time;Tissues;transcriptome;Untranslated RNA;Validation;Variant;whole genome;Work

PROJECT_TITLE: Genomics of Post-Operative Atrial Fibrillation After Cardiac Surgery

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: BATON ROUGE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: PROJECT NARRATIVE  The perspectives of sexual minority youth are vastly underrepresented in extant theories, research, treatment development for suicide prevention, particularly considering the substantially elevated rate of suicidal thoughts and behaviors in sexual minority populations. Failure to incorporate the voices and lived experiences of sexual minority youth perpetuates health disparities, underutilization of treatment, and treatment dropout among sexual minority youth. Using a rigorous, ethnographic approach called Cultural Consensus Modeling, this project will provide an empirically-based multi-method model of the shared cultural determinants of suicidal thoughts and behaviors among sexual minority youth, as perceived by sexual minority youth themselves, to inform culturally relevant treatment targets and provide clear recommendations for adapting theoretical models of suicide to address the needs of sexual minority youth.

PI_NAMEs: HILL, RYAN  (contact);SHARP, CARLA

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: Address;Age;Assessment tool;Behavior;Consensus;Data;Discrimination;Dropout;Elements;Ethnography;evidence base;Failure;Feeling suicidal;Female;Funding;Future;Gender;Goals;health disparity;Heterosexuals;Individual;Individual Differences;informant;innovation;Intervention;Interview;Knowledge;lens;Lived experience;Maps;Measures;Methodology;Methods;microaggression;minority stress;Modeling;Motivation;National Institute of Mental Health;National Institute on Minority Health and Health Disparities;Nature;Participant;peer;Phase;Population;Positioning Attribute;predictive modeling;Prevention;Prevention program;preventive intervention;Process;Property;protective factors;Psychological Theory;Psychometrics;Questionnaires;Recommendation;Recording of previous events;recruit;reducing suicide;Reporting;Research;Risk;Risk Factors;Sampling;Severities;sexual minority;sexual minority group;sexual minority youth;Stress;Students;Subgroup;suicidal behavior;suicidal risk;Suicide;Suicide attempt;suicide model;Suicide prevention;suicide rate;Testing;Theoretical model;theories;therapy development;Time;United States National Institutes of Health;Update;Voice;Work;Youth

PROJECT_TITLE: Cultural Consensus Modeling to Identify Culturally Relevant Risk and Protective Factors for Suicide among Sexual Minority Youth

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Parkinson’s disease is a progressive neurodegenerative disorder with both motor and non-motor features whose pathologic hallmark is misfolded α-synuclein. This proposal’s goals are to identify the tissue source of pathologic α-synuclein strains found in human plasma in an unbiased manner and determine the biochemical and functional properties of these strains by introducing them into cellular models. Understanding the origin and properties of circulating forms of α-synuclein could lead to therapies that target early disease mechanisms.

PI_NAMEs: KANNARKAT, GEORGE T (contact)

PROJECT_TERMS: Advisory Committees;Affect;alpha synuclein;Antibodies;Area;Award;Basic Science;Binding;Biochemical;Bioinformatics;Biological;Biological Assay;Biological Markers;biomarker identification;Biometry;Body Fluids;Brain;Brain Diseases;Cell model;Cell secretion;cell type;cellular pathology;Central Nervous System;Centrifugation;Cerebrospinal Fluid;Clinical;Clinical Research;cohort;Data;Dementia with Lewy Bodies;Development;diagnostic biomarker;Digestion;Disease;Electron Microscopy;Endopeptidase K;Environmental Exposure;Erythrocytes;Event;experience;experimental study;extracellular vesicles;FDA approved;Funding;Goals;Health Care Costs;Human;human tissue;Immune;Immunoprecipitation;Impaired cognition;improved;In Vitro;in vitro Assay;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Inflammation;innovation;Institution;instructor;interest;Investigation;Laboratories;Learning;Lewy Bodies;Lewy neurites;Lipid Binding;Maps;Mass Spectrum Analysis;Membrane;Mentors;Mentorship;Methods;MicroRNAs;Microscopy;miRNA expression profiling;Mission;Modeling;Molecular Conformation;Molecular Sieve Chromatography;Monoclonal Antibodies;monomer;Morbidity - disease rate;Motor;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;Neuronal Dysfunction;Neurons;Neurosciences;neurotoxicity;novel;novel therapeutics;Nucleic Acids;overexpression;Parkinson Disease;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pennsylvania;Peripheral;Peripheral Nervous System;Persons;Physicians;Plasma;Productivity;Property;Proteins;Proteomics;Qualifying;Reporting;Research;Research Methodology;Resistance;Resources;RNA;Route;Sampling;Scientific Inquiry;Scientist;Sedimentation process;Self Direction;skills;Source;Structure;Surface;synergism;synuclein;synucleinopathy;targeted treatment;Testing;Therapeutic;therapy development;tissue resource;Tissues;Training;Training Programs;Translational Research;Translations;Universities;Visualization;Work

PROJECT_TITLE: Determining the Origin and Pathogenicity of Plasma-Derived Alpha-SynucleinStrains


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biotechnology;Kidney Disease;Natural Products;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE End-stage kidney disease affects more than four million patients globally and these patients require hemodialysis. The arteriovenous fistula (AVF) is the preferred vascular access for hemodialysis and majority of AVFs fail due to venous neointimal hyperplasia (VNH) and venous stenosis (VS).

PI_NAMEs: MISRA, SANJAY  (contact)

PROGRAM_OFFICER_NAME: REID, DIANE M

PROJECT_TERMS: Adhesions;Adipose tissue;Affect;Age;aging process;Anti-Inflammatory Agents;Arteriovenous fistula;Autologous;Balloon Angioplasty;Blinded;Blood flow;Blood Vessels;Cd68;Cell Cycle Kinetics;Cell Differentiation process;Cell Physiology;Cell Separation;Cells;Chronic Kidney Failure;comparison control;Cues;cytokine;Dasatinib;Data;Dialysis patients;Dialysis Solutions;efficacy evaluation;End stage renal failure;Endothelial Cells;experimental study;Family suidae;Female;Fibrosis;Functional disorder;functional improvement;Future;gain of function;Gene Expression;Genes;Goals;Hemodialysis;Histologic;Histology;Human;Hyperplasia;Hypoxia;Image;improved;In Vitro;Inflammation;Inflammatory;Inflammatory Response;Kinetics;Knowledge;Label;Legal patent;Location;loss of function;Macrophage;Mediating;Mesenchymal Stem Cells;migration;Modeling;Molecular;Monitor;monocyte;Mus;normal aging;Organ;Pathway interactions;Patients;Peroxisome Proliferators;Pharmaceutical Preparations;Phase I Clinical Trials;Placebos;porcine model;Positron-Emission Tomography;PPARG gene;prevent;primary endpoint;procedure cost;Procedures;Production;Proliferating;Quercetin;Randomized;responders and non-responders;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Signal Transduction;Smooth Muscle Myocytes;STAT protein;STAT3 gene;stem cell delivery;stem cell therapy;Stenosis;Testing;therapy development;Time;Tissue-Specific Gene Expression;TP53 gene;transcriptome sequencing;translational study;Upper Extremity;uptake;Vascular remodeling;Veins;Venous;Xenograft procedure

PROJECT_TITLE: The role of hypoxia in venous neointimal hyperplasia in hemodialysis grafts

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Lung;Pediatric;Pulmonary Hypertension;Rare Diseases

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative: At present, no disease-modifying therapies exist for patients with pulmonary arterial hypertension. While it is known that increased pulmonary blood flow can lead to structural changes in the distal arterioles, the underlying mechanisms remain unclear. My study will provide novel insights into the contribution and involvement of smooth muscle cells to flow-induced vascular remodeling. Additionally, my work will establish new murine models that will provide a valuable resource for future researchers investigating pulmonary hypertension.

PI_NAMEs: KLOUDA, TIMOTHY  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: AMD3100;Animal Model;antagonist;arteriole;atrioventricular septal defect;Blood flow;Blood Vessels;Cardiopulmonary;career;Cell Proliferation;Cell Separation;Cells;Circulation;comparison control;congenital heart abnormality;Contracts;Data;Development;Diagnosis;Disease;Disease Progression;Distal;end stage disease;Endothelial Cells;Excision;experimental study;Exposure to;Functional disorder;Future;Goals;Green Fluorescent Proteins;high risk;Histologic;Human;Hypoxia;hypoxia-induced pulmonary hypertension;Immunofluorescence Immunologic;improved;indexing;Infection;insight;Lead;Left;Lung;Measurement;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Muscle;novel;novel therapeutic intervention;Operative Surgical Procedures;Pathway interactions;Patient Representative;Patient-Focused Outcomes;Patients;Pericytes;Physicians;Physiological;Pneumonectomy;Postoperative Period;prevent;primary pulmonary hypertension;pulmonary arterial hypertension;pulmonary arterial pressure;Pulmonary artery structure;Pulmonary Hypertension;Rattus;receptor;Research;Research Personnel;Resources;response;Right Ventricular Hypertrophy;Right ventricular structure;Risk;RNA Sequences;Rodent Model;Role;Scientist;Secondary to;shear stress;Shunt Device;Side;Signal Transduction;Sleep Apnea Syndromes;Smooth Muscle Myocytes;Source;Stains;Stromal Cell-Derived Factor 1;Structure of parenchyma of lung;Systolic Pressure;Testing;Therapeutic;therapeutic development;Time;transcriptomics;Up-Regulation;Vascular Diseases;Vascular remodeling;Ventricular Septal Defects;Work

PROJECT_TITLE: Mural cells contribution to vascular remodeling in flow induced pulmonary hypertension

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (MA)]


NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: DURHAM

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Gastrointestinal (GI) dysfunction may be an early manifestation of Parkinson's disease (PD), the second most common neurodegenerative disorder. The Gut Brain Parkinson's Disease Consortium (GBPDC) will support the establishment of the GBPDC biorepository and accelerate the development of innovative early-phase GI-based research tools and biomarkers for PD. Our proposed Clinical Data Management Center will establish the required infrastructure, data management, analytics, and resource-sharing functions to efficiently support the establishment of the program with a focus on expanded reach, efficiency, and accelerated data analysis and result dissemination.

PI_NAMEs: NEWBY, LAURA KRISTIN;SANDERS, LAURIE H;WRUCK, LISA M (contact)

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: Acceleration;Address;Affect;Area;biobank;Biological Markers;Biological Specimen Banks;Bradykinesia;Brain;Chronic;Clinical;Clinical Data;clinical diagnosis;Clinical Research;Collaborations;Collection;Communication;Communities;Complex;Contract Services;Data;Data Analyses;Data Analytics;Data Coordinating Center;data dissemination;data management;Data Science;data sharing;design;Development;Diagnostic;diagnostic biomarker;diagnostic tool;Disease;dopaminergic neuron;early phase clinical trial;Ecosystem;Ensure;Etiology;flexibility;Functional disorder;Future;gastrointestinal;Generations;gut dysbiosis;gut-brain axis;improved;Information Dissemination;Infrastructure;innovation;Knowledge;Laboratories;Lead;Leadership;Maintenance;Mission;Monitor;Motor;Movement Disorders;National Institute of Diabetes and Digestive and Kidney Diseases;Nerve Degeneration;Neurodegenerative Disorders;Neurologic Symptoms;Online Systems;Parkinson Disease;pars compacta;Pathogenesis;Pathologic;Pathology;Persons;Phase;Positioning Attribute;posture instability;program dissemination;programs;Protocols documentation;Reporting;Research;Research Contracts;Research Institute;Research Personnel;Research Proposals;Resource Sharing;Resources;response;Role;Scanning;Science;Services;Statistical Data Interpretation;Statistical Methods;Structure;Substantia nigra structure;therapeutic target;Time;tool;Training;Tremor;Validation;Vision

PROJECT_TITLE: The Gut Brain Parkinson's Disease Consortium (GBPDC): Coordinating and Data Management Center (CDMC)

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-C (M2)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Alzheimer’s disease can affect people younger than age 65, yet it is unclear whether the disease is different in middle aged people compared to older individuals. This research project aims to advance our understanding of the protein changes that occur in Alzheimer’s disease in people younger than age 65. Such knowledge is critical to ensure that diagnostic tests and therapies developed for Alzheimer’s disease are applicable to this younger population.

PI_NAMEs: JOHNSON, ERIK C.B. (contact)

PROGRAM_OFFICER_NAME: PETANCESKA, SUZANA

PROJECT_TERMS: Acceleration;Advanced Development;Affect;Age;Aggressive Clinical Course;Aging;aging population;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease risk;Alzheimer's disease therapeutic;Amyloid beta-Protein;autosomal dominant Alzheimer's disease;autosome;Behavioral;Biological;Biological Markers;Brain;brain based;case control;Cerebrospinal Fluid;Cerebrospinal Fluid Proteins;Clinical;Cognitive;cohort;Complement;Data;Development;Diagnostic;Diagnostic tests;differential expression;Disease;DNA Sequence Alteration;early onset;Early Onset Alzheimer Disease;Elderly;Ensure;Functional disorder;Genetic;Goals;Heritability;human old age (65+);Impaired cognition;Impairment;Individual;Inherited;innovation;Knowledge;Language;Late Onset Alzheimer Disease;Link;Maps;Mass Spectrum Analysis;Measures;Medicine;middle age;Mitochondria;mitochondrial dysfunction;Modification;Molecular;Mutation;Nature;neuropathology;Older Population;Pathologic;Pathologic Processes;Pathway interactions;Persons;Plasma;Plasma Proteins;Population;Predisposition;Prefrontal Cortex;prognostic;protein biomarkers;Proteins;Proteome;Proteomics;proteostasis;proteostasis loss;racial diversity;Research Personnel;Research Project Grants;resilience;resilience factor;Risk;Risk Factors;RNA;Sampling;Special Population;Synapses;Syndrome;System;tau Proteins;Therapeutic;therapeutic biomarker;therapeutic target;therapy development;Time;Tissues;trait;Translating;Visuospatial;Work

PROJECT_TITLE: A Proteomic Comparison of Sporadic Early-Onset, Late-Onset, and Autosomal Dominant Alzheimer's Disease


PHR: PROJECT NARRATIVE Cervical dystonia (CD) is a chronic, disabling neurologic disorder for which available treatments are purely symptomatic and not satisfactory in 20-40% of patients. Lack of known biologic pathways associated with the pathogenesis of CD has limited development of point of care tests that are urgently needed to diagnose and guide the treatment of CD. This research project will utilize immunophenotyping, gene expression profiling, and quantitative neuroanatomical methods to advance our understanding of pathogenic immune mechanisms in CD, and may ultimately direct the development of better diagnostic tools and guide research for the development of disease modifying therapies.

PI_NAMEs: SCORR, LAURA M (contact)

PROJECT_TERMS: Address;Affect;Age;analytical method;Astrocytes;Astrocytosis;autoimmune thyroid disease;Autopsy;autoreactive T cell;B-Lymphocytes;Basal Ganglia;biobank;Bioinformatics;Biological;Biology;Blood;Body Regions;Brain;brain cell;Brain region;Brain Stem;brain tissue;career;career development;Cell Physiology;Cells;Cerebellum;Cervical Dystonia;Chronic;Clinical;clinical care;clinical epidemiology;Clinical Investigator;collaborative environment;comparison control;Competence;Cross-Sectional Studies;cytokine;Data;Data Science;detection method;Development;Diagnosis;diagnostic development;diagnostic strategy;Diagnostic tests;diagnostic tool;Disabling;Disease;Dropout;Dystonia;Etiology;Formalin;Frequencies;Funding;Future;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;Goals;Heterogeneity;Human;Immune;immune activation;immune cell infiltrate;immune function;Immunity;Immunologic Markers;Immunologics;Immunologist;Immunology;Immunophenotyping;indexing;Individual;Infiltration;Inflammatory;inflammatory marker;International;Lead;Macrophage;Mediating;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;metabolome;Methods;Microglia;Microscopy;Movement;multidisciplinary;Muscle Contraction;Nervous System;Nervous System Disorder;Neuroanatomy;Neuroimmune;neuroimmunology;Neuroimmunomodulation;neuropathology;novel;novel diagnostics;novel therapeutic intervention;novel therapeutics;Pain;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Pattern;Penetrance;Peripheral;Persons;phenomenological models;Physicians;Pilot Projects;Plasma;Play;point of care testing;Population;Positioning Attribute;Posture;preservation;programs;Proteome;Purkinje Cells;Reporting;Research;research and development;Research Personnel;Research Project Grants;Research Training;Resources;Role;Scientist;Signal Transduction;Somatosensory Cortex;Sorting;Specimen;Stains;Standardization;Statistical Computing;Subgroup;Syndrome;T cell infiltration;T-Cell Activation;T-Lymphocyte Subsets;Therapeutic;therapeutic development;Training;transcriptome;transcriptomics;treatment strategy;United States National Institutes of Health;Universities;Whole Blood

PROJECT_TITLE: Immune Mechanisms in Cervical Dystonia