ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Genetics;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: ORTHOPEDICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: NARRATIVE Surgical re-attachment of torn tendons to their bony insertions is a clinically significant problem, especially in the shoulder and knee (e.g., current failure rates after rotator cuff repair range from 20% to 94%, depending on the patient population). This research will define the critical developmental events that lead to a robust tendon- to-bone attachment and explore their role during healing. Results will lead to enhanced tendon-to-bone healing and subsequently in improvements in the health and quality-of-life of individuals afflicted with rotator cuff and anterior cruciate ligament injuries.

PI_NAMEs: THOMOPOULOS, STAVROS  (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Ablation;Acute;Adult;Agonist;anterior cruciate ligament injury;Architecture;Automobile Driving;Biological Assay;Biomechanics;bone;bone healing;bone repair;Cartilage;Cell Differentiation process;Cell Lineage;Cells;Chondrocytes;Cicatrix;clinically significant;Connective Tissue;Cues;Development;Differentiation Antigens;Embryo;Erinaceidae;Event;Extracellular Matrix;Failure;fetal;Fibrocartilages;Future;gain of function;Genetic;Genetic Transcription;Goals;Growth;healing;Health;improved;Individual;Injury;Knee;Knowledge;loss of function;mechanical properties;Mechanics;Mediating;mineralization;Minerals;Modeling;Molecular;Morphology;Mus;Muscle;Natural regeneration;Neonatal;Older Population;Operative Surgical Procedures;Outcome;Pain;Pathway interactions;patient population;Phenotype;Physiological;Pilot Projects;Population;postnatal;postnatal development;prevent;Process;progenitor;programs;Quality of life;regenerative;regenerative approach;repaired;Repeat Surgery;Reporter;Research;response;Role;Rotator Cuff;Rupture;Shoulder;Signal Transduction;single-cell RNA sequencing;Site;smoothened signaling pathway;stem cell differentiation;stem cell niche;stem cell therapy;stem cells;Stress;Tendon Injuries;Tendon structure;Testing;Therapeutic;Tissues;transcription factor;Transcriptional Regulation;transcriptome;United States;Work

PROJECT_TITLE: Formation of a functional tendon enthesis during development and healing

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Pediatric;Social Determinants of Health;Violence Research

ORG_CITY: SALT LAKE CITY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Pathological aggression is a recurrent pattern of disruptive and violent behavior, with a staggering socioeconomic impact. In the previous funding period, we developed and characterized the first mouse model reproducing gene- environment interactions in pathological aggression. In this renewal application, we propose to use this model to examine the biological mechanisms underlying the development of this condition from early life to adulthood.

PI_NAMEs: BORTOLATO, MARCO  (contact);MANGIERI, REGINA A.

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: addiction;Adolescence;Adult;age related;Aggressive behavior;Alleles;androgenic;Animal Model;Area;base;Behavior;Behavioral;Biological;Brain;Castration;Child Abuse and Neglect;Chronic;Complex;conditioned place preference;Cues;Data;Development;Diagnosis;Dopamine;Dopaminergic Cell;early life stress;Economic Burden;economic impact;Enzymes;Exposure to;Female;fighting;Funding;gene environment interaction;Genes;Glutamates;Goals;Growth;Heterogeneity;HTR2A gene;Impairment;Impulsivity;Individual;Knock-out;Lead;Life;male;Male Adolescents;Male Castration;Measures;Meditation;mesolimbic system;Methaqualone;Modeling;Monoamine Oxidase A;mouse model;Mus;mutant;Mutation;neurobiological mechanism;Neurobiology;Neuronal Plasticity;neurophysiology;neurotransmission;Nucleus Accumbens;Output;Pathologic;Pathway interactions;Pattern;Phenotype;Plasma;postnatal;Prefrontal Cortex;prevent;Prevention;Process;Psychological reinforcement;Puberty;pup;Pyramidal Cells;Receptor Activation;Recurrence;Regimen;Research;response;Rewards;Risk Factors;Self Administration;Serotonin;Serotonin Receptor 5-HT2A;Sex Differences;Shapes;social;socioeconomics;ST5 gene;Stanolone;stem;Steroids;Stimulus;Stress;Structure;Substance of Abuse;Testing;Testosterone;Therapeutic;Time;transcriptomics;transmission process;Ventral Tegmental Area;Violence;young adult

PROJECT_TITLE: Deciphering gene-environment interactions in pathological reactive aggression

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Genetics;Rare Diseases;Stomach Cancer

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Neoglycosylation epitopes have been widely used to aid in the diagnosis as well as the management of metaplasia and cancers; however, the function of these epitopes is unknown. Here, we begin to study how these epitopes orchestrate the metaplastic and oncogenic transformations in foregut metaplasias and cancer using in vitro cell and organoid culture as well as murine models. Specifically, we focus on the transition from sialylation to sulfated epitopes, which has been associated with increased likelihood of progressing to gastric cancer by numerous groups over the past several decades.

PI_NAMEs: BROWN, JEFFREY WADE (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Advisory Committees;apical membrane;Barrett Esophagus;Binding;Biological Assay;Biological Markers;Cancer Etiology;Career Choice;career development;cell dedifferentiation;Cell Differentiation process;Cell Line;Cell Maturation;Cell Physiology;Cells;Characteristics;Chief Cell;clinically significant;Cytoplasmic Granules;Development Plans;Diagnosis;Doctor of Medicine;Doctor of Philosophy;E-Cadherin;Ensure;Epitopes;experimental study;Fellowship;Fractionation;Funding;Galactose Binding Lectin;Galectin 3;gastric intestinal metaplasia;Gastroenterology;Gene Chips;Gene Deletion;Gene Expression Profile;Genes;Genetic Models;Genetic Transcription;Glean;Glycobiology;glycosylation;Goals;Greek;High grade dysplasia;high risk;Homeostasis;Immunoelectron Microscopy;Immunofluorescence Immunologic;In Vitro;instructor;Intestinal Metaplasia;K-Series Research Career Programs;Knock-out;Knockout Mice;Knowledge;Knowledge acquisition;Label;Laboratories;loss of function;LS174T colon cancer cell line;Lysosomes;Malignant neoplasm of esophagus;Malignant Neoplasms;malignant stomach neoplasm;Mediating;medical schools;Medicine;Membrane;Mentors;Mentorship;Metaplasia;Metaplastic Cell;metaplastic cell transformation;Molecular;Monitor;mortality;mouse model;Mucins;Mus;novel;Oncogenic;Organoids;Pancreatic cystic neoplasia;Phenotype;Polysaccharides;Positioning Attribute;prevent;Primitive foregut structure;Process;Production;Program Development;programs;progression risk;protein transport;Proteins;Proteome;Repression;Research;Research Personnel;Risk;Role;segregation;Sialic Acids;sialylation;Signal Pathway;Signal Transduction;skills;small molecule inhibitor;Stomach;success;Sulfate;sulfomucin;System;Technical Expertise;Techniques;Tissues;tool;trafficking;Transmission Electron Microscopy;tumorigenesis;Universities;Washington;Work

PROJECT_TITLE: Neoglycosylation Epitopes in Metaplasia and Cancer

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Neurodegenerative;Patient Safety;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation

ORG_CITY: Springfield

ORG_NAME: OREGON RESEARCH INSTITUTE

ORG_STATE: OR

PHR: PROJECT NARRATIVE The evidence that physical exercise reduces falls in older adults with cognitive impairment is currently both limited and inconclusive, making it difficult for recommending best practices. The proposed study is intended to fill this gap. The primary objective of this project is to determine the efficacy of the therapeutically tailored, cognitively enhanced, dual-task Tai Ji Quan: Moving for Better Balance intervention in reducing the incidence of falls among older adults with mild cognitive impairment, a population that is at an increased risk of falling and increased risk of developing Alzheimer’s disease and Alzheimer’s disease-related dementias. Because the problem of falls is directly relevant to the growing aging population in the United States, our project has the potential to have broad societal impact by ameliorating risk of falls in older Americans with cognitive impairment, improving their physical and cognitive health, and lessening the health care burden due to falls and falls injuries and cognitive decline.

PI_NAMEs: LI, FUZHONG  (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: Activities of Daily Living;Address;Age-associated memory impairment;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;American;arm;Attention;Balance training;Clinical;clinical practice;Clinical Practice Guideline;Clinical Trials;Cognitive;cognitive ability;cognitive enhancement;cognitive function;cognitive performance;cognitive task;Communities;community setting;comparative efficacy;Country;Coupled;Data;design;Educational Intervention;efficacy evaluation;eHealth;equilibration disorder;Equilibrium;evidence based guidelines;executive function;Exercise;exercise intervention;Exercise Therapy;Exhibits;experience;fall injury;Fall prevention;fall risk;falls;follow-up;Gait;Goals;Health;healthcare burden;Impaired cognition;Impairment;improved;Incidence;innovation;insight;instructor;Intervention;intervention delivery;Knowledge;Mediating;Methodology;mild cognitive impairment;mind/body;Modeling;Motor;Movement;multitask;Musculoskeletal Equilibrium;Nonpharmacologic Therapy;novel;older adult;Outcome;Participant;patient engagement;Performance;Persons;Physical Exercise;Physical Performance;Population;Populations at Risk;post intervention;Prevention Guidelines;preventive intervention;primary outcome;programs;Public Health;Randomized, Controlled Trials;Recommendation;Research;response;Risk;Risk Factors;secondary outcome;Single-Blind Study;Stretching;Tai Ji;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Time;Training;Treatment Efficacy;United States;virtual;walking performance;Work

PROJECT_TITLE: Dual-Task Training Exercise to Reduce Falls in Older Adults with Mild Cognitive Impairment

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Los Angeles

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE Regulation of stem cell functions is crucial for tissue formation, growth, and homeostasis in adult organisms. Our study seeks to investigate how the transition of mesenchymal stem cells (MSCs) into transit amplifying cells (TACs) is regulated in the continuously growing adult mouse incisor in support of tissue homeostasis. Ultimately, this study will reveal how the trigeminal nerve serves as a niche environment for MSCs and elucidate the signaling network that regulates the interactions between MSCs and TACs in maintaining tissue homeostasis, which may lead to new strategies for stem cell-mediated tissue regeneration.

PI_NAMEs: CHAI, YANG  (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: Adult;adult stem cell;Animal Model;Animals;ARID1A gene;AVIL gene;Cell Communication;Cell Differentiation process;Cell Physiology;Cells;Cervical;Data;Environment;Epigenetic Process;Feedback;FGFR1 gene;Growth;Homeostasis;Incisor;insight;Life;Maintenance;Mediating;Mesenchymal;Mesenchymal Stem Cells;Modeling;Molecular;Mus;Mutant Strains Mice;Nerve;nerve supply;neurovascular;Organ;Organism;Phenotype;Play;Population;Positioning Attribute;Regulation;repaired;Role;self-renewal;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;stem cell differentiation;stem cell function;stem cell model;stem cell niche;stem cell population;stem cells;Testing;tissue regeneration;Tissues;Tooth regeneration;Tooth structure;TP53 gene;Trigeminal nerve structure;Undifferentiated

PROJECT_TITLE: MOLECULAR REGULATORY MECHANISM OF MESENCHYMAL STEM CELLS IN ADULT MOUSE INCISOR

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: DURHAM

ORG_DEPT: PSYCHOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: RELEVANCE By elucidating the neural mechanisms in the basal ganglia underlying instrumental learning and action selection, proposed research can shed light on the treatment of numerous disorders that implicate the same neural circuits, such as addiction, obsessive-compulsive disorder, and schizophrenia.

PI_NAMEs: YIN, HENRY  (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: 3-Dimensional;addiction;Anatomy;association cortex;Basal Ganglia;Behavior;Behavioral;Behavioral Assay;Bilateral;Brain region;Brain Stem;Cell Nucleus;Cells;Cerebral cortex;Collection;Consensus;Corpus striatum structure;Development;Disease;Dopamine Receptor;Expectancy;experimental study;Feedback;flexibility;Functional disorder;genetic manipulation;Goals;Habits;hippocampal pyramidal neuron;Impairment;in vivo calcium imaging;Learning;learning outcome;Lesion;Medial;Mental disorders;Monitor;Motion;motor control;Motor Cortex;Movement;Mus;Nervous System Disorder;neural;neural circuit;neuromechanism;Neurons;Obsessive-Compulsive Disorder;Operant Conditioning;optogenetics;Outcome;Pathway interactions;Pattern;Performance;Play;Population;Prefrontal Cortex;Process;Psychological reinforcement;Pyramidal Tracts;receptor;recruit;Research;Rewards;Role;Schizophrenia;Shapes;Signal Pathway;Signal Transduction;Spinal Cord;Symptoms;Testing;Transgenic Mice;Work

PROJECT_TITLE: Dissecting basal ganglia circuit mechanisms underlying instrumental learning


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: CHARLESTON

ORG_DEPT: NEUROLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE The goal of this project is to elucidate the changes in white matter microstructure that signal the shift from healthy to pathological brain aging using advanced diffusion MRI methods. Expected outcomes from this study include clinically feasible MRI biomarkers with which to empirically test a proposed conceptual model of white matter- related changes in aging and AD, thereby providing translational support for trials of myelin/glia-focused therapies which are grossly underexplored for asymptomatic AD. Thus, this study is poised to have an impact on the evolving conceptualization of how aging leads to AD and, critically, how this can be prevented or treated.

PI_NAMEs: BENITEZ, ANDREANA  (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: 3-Dimensional;Address;Age;age related;Aging;aging brain;Alzheimer's Disease;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;amyloid imaging;amyloid pathology;asymptomatic Alzheimer's disease;Axon;beta amyloid pathology;Biological Assay;Biological Markers;biophysical model;Brain;Clinical;Clinical Research;Clinical Trials;clinically relevant;Cognitive;cohort;Data;data modeling;Dementia;density;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Disease Progression;Elderly;Failure;Fiber;follow-up;Funding;Geometry;Gliosis;Goals;Grant;Health;Hippocampus;Image;Impaired cognition;Inflammation;innovation;Knowledge;Lesion;Longitudinal cohort;Longitudinal cohort study;Longitudinal Studies;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Magnetic Resonance Spectroscopy;Maintenance;Measures;Methods;Microscopic;mild cognitive impairment;Modeling;Monitor;Myelin;Myelin Water Imaging;myoinositol;N-acetylaspartate;Natural History;Natural Immunity;Nerve Degeneration;Neuroglia;neuroimaging;neuroimaging marker;Neuropsychological Tests;normal aging;Outcome Study;pandemic disease;Participant;Pathologic;pathological aging;Phase;Positron-Emission Tomography;pre-clinical;pre-clinical therapy;prevent;Procedures;Process;Questionnaires;recruit;Relaxation;repaired;response;retention rate;Risk Factors;Sample Size;senescence;Signal Transduction;Structure;Techniques;Testing;therapy development;Time;Tissues;trend;Visualization;Water;white matter;white matter change;Work

PROJECT_TITLE: Quantitative Neuroimaging Assessment of White Matter Integrity in the Context of Aging and AD

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ATHENS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Narrative  Chronic environmental exposure to the heavy metal manganese (Mn) through occupational and industrial sources causes motor and not-motor neurological deficits, culminating in metal-induced Parkinsonism. Even though it is well known that Mn neurotoxicity primarily affects the globus pallidus and striatum regions, the molecular mechanisms underlying the metal-induced differential neuronal vulnerability and olfactory alterations are not well understood. In this proposal, we intend to characterize the role of a compensatory signaling pathway mediated by the neuropeptide prokineticin 2 in Mn-induced olfactory alterations and basal ganglia neurotoxicity and to further evaluate the translational neuroprotective efficacy of activating this signaling pathway using both cell and animal models of Mn neurotoxicity.

PI_NAMEs: KANTHASAMY, ANUMANTHA GOUNDER (contact);KANTHASAMY, ARTHI

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Adult;Affect;Agonist;Animal Model;Animals;Anosmia;astrocyte progenitor;Astrocytes;Basal Ganglia;Brain region;C57BL/6 Mouse;Cell model;Cell Nucleus;Cells;Chemotactic Factors;Chronic;cognitive disability;Corpus striatum structure;Data;Dendroaspis;Disparity;Dose;Environment;Environmental Exposure;Etiology;Exposure to;Functional disorder;Gene Expression;gene therapy;Globus Pallidus;Goals;Health;Heavy Metals;Homologous Gene;Human;human tissue;Idiopathic Parkinson Disease;Impairment;In Vitro;in vivo;Induced Neurons;Industrialization;insight;Kallmann Syndrome;Link;Manganese;Maps;Mediating;Metal exposure;Metals;migration;Modeling;Molecular;Motor;motor deficit;motor impairment;mouse model;Nerve Degeneration;nerve stem cell;neural circuit;neurobehavioral;Neurodegenerative Disorders;neurogenesis;Neurologic Deficit;Neurologic Dysfunctions;neuron loss;Neuronal Dysfunction;neuronal survival;Neurons;Neuropeptides;neuroprotection;neuropsychiatry;neurotoxic;neurotoxicity;neurotoxicology;Neurotoxins;neurotrophic factor;novel;novel therapeutic intervention;Occupational;olfactory bulb;Olfactory dysfunction;Parkinson Disease;Parkinsonian Disorders;Pathogenesis;Pathology;Pathway interactions;Pattern;Peptides;pharmacologic;Phase;Predisposition;Prosencephalon;protective effect;receptor;receptor expression;Recombinants;release factor;Reporting;response;Role;Signal Pathway;Signal Transduction;Source;Stream;Stress;subventricular zone;System;Therapeutic;Time;translational approach;Up-Regulation;Venoms

PROJECT_TITLE: Role of Prokineticin 2 in Metal Neurotoxicity

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Although multimorbidity affects >36 million older adults in the US, there is a paucity of data to guide medication prescribing by multimorbidity burden. This proposal will leverage high-quality data and innovative methods to evaluate the impact of multimorbidity on modulating the safety and effectiveness of cardiometabolic therapies among older adults. Study findings will help patients, caregivers, and clinicians to make individualized evidence- based treatment decisions

PI_NAMEs: DAVE, CHINTAN  (contact)

PROGRAM_OFFICER_NAME: EINHORN, PAULA T

PROJECT_TERMS: Address;Adult;Adverse reactions;Affect;Aging;Anti-diabetic Drugs;Anticoagulants;Antiplatelet Drugs;Area;Atherosclerosis;Atrial Fibrillation;beneficiary;Benefits and Risks;burden of illness;cardiometabolism;Cardiovascular Diseases;Cardiovascular system;Caregivers;Cessation of life;Clinical;Clinical Data;Clinical Trials;clinically relevant;clopidogrel;cognitive function;cost;Data;Databases;Dementia;Disease;Drug Prescriptions;Drug Utilization;Effectiveness;Elderly;electronic health database;Event;evidence base;Evidence based treatment;Exclusion;Fee-for-Service Plans;functional independence;functional loss;Geriatrics;Glucose;health data;Healthcare;Hemorrhage;Heterogeneity;High Prevalence;Home;Impaired cognition;indexing;Individual;inhibitor;innovation;life span;Link;Measures;Medical;Medicare;Methods;middle age;Morbidity - disease rate;mortality;multiple chronic conditions;New Agents;Non-Insulin-Dependent Diabetes Mellitus;novel;Nursing Homes;Observational Study;older adult;Older Population;Oral;Outcome;Outcome Measure;Patients;Pharmaceutical Preparations;Physical Function;Play;Polypharmacy;Population;Prevalence;Research;Role;Safety;social deprivation;social health determinants;social vulnerability;Sodium;Source;Surveys;symporter;Time;treatment effect;uptake;Warfarin

PROJECT_TITLE: Evaluating the role of multimorbidity in modulation medication effects in older adults

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Lung;Prevention;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Bronchiolitis obliterans syndrome after allogeneic hematopoietic cell transplant is a highly morbid manifestation of chronic graft-versus-host disease which is poorly understood, hampering our ability to intervene effectively. We hypothesize that cumulative burden of symptomatic and asymptomatic respiratory viral infections contributes to the development of BOS and progressive lung dysfunction, leading to poor outcomes. In this proposal we will conduct a multicenter longitudinal prospective study on the association of respiratory viral infection and lung function trajectory in patients at risk for and with a clinical diagnosis of BOS, by utilizing home spirometry, self- collection of viral PCR, and a novel serosurvey (VirScan), to fully characterize the natural history of BOS.

PI_NAMEs: CHENG, GUANG-SHING  (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: 2019-nCoV;Acceleration;Address;Adult;allogeneic disease;Allogenic;Area;Biological;Biological Assay;Blood;Bronchiolitis Obliterans;Child;Childhood;chronic graft versus host disease;Clinic;Clinical;clinical diagnosis;clinically relevant;clinically significant;cloud based;cohort;Collection;Coupled;COVID-19 pandemic;Data;design;Development;Devices;Diagnosis;Disease;Early Diagnosis;Early Intervention;Enrollment;Epidemiology;Epitopes;Event;flu;follow-up;Forced expiratory volume function;Functional disorder;Goals;Hematopoietic Stem Cell Transplantation;high risk;Home;Human Metapneumovirus;Impairment;improved;improved outcome;Infection;Influenza;innovation;Intervention;isoimmunity;Knowledge;Longitudinal Studies;longitudinal, prospective study;Lung;Lung Diseases;Medical;Monitor;mortality;nasal swab;Natural History;Newly Diagnosed;novel;novel therapeutics;Outcome;Parainfluenza;Pathogenesis;Pathogenicity;patient stratification;Patients;Phenotype;post-transplant;Procedures;prospective;pulmonary function;pulmonary function decline;Pulmonary Function Test/Forced Expiratory Volume 1;Pulmonary function tests;Quality of life;Questionnaires;Recording of previous events;remote health care;respiratory;Respiratory syncytial virus;respiratory virus;Risk;Risk Factors;risk stratification;Role;sample collection;Serology test;serosurvey;Serum;Spirometry;Survivors;Symptoms;Syndrome;Technology;Testing;Therapeutic Intervention;Time;Transplant Recipients;Upper respiratory tract;Viral;Viral Load result;Viral Respiratory Tract Infection;virome;Virus;wireless

PROJECT_TITLE: Longitudinal Impact of Respiratory Viruses on Bronchiolitis Obliterans Syndrome in Allogeneic Hematopoietic Cell Transplant Recipients

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: BALTIMORE

ORG_DEPT: PATHOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Targeting the conserved epitopes of virus' and neoepitopes in cancer are parts of a new wave of immunotherapy “vaccine” strategy. We seek to boost cell mediated responses to these epitopes using a system that targets them for destruction similar to a knockdown PROTAC strategy.

PI_NAMEs: ROSARIO, MAXIM  (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Acids;Adjuvant;Animal Model;Antigen Presentation;Attention;Biological Assay;cancer therapy;Cancer Vaccines;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cellular Immunity;chemical conjugate;Clinical;Coculture Techniques;Communicable Diseases;Cytosol;cytotoxic;Dendritic Cells;effector T cell;Encapsulated;Endosomes;Epitopes;experimental study;FDA approved;Flow Cytometry;Goals;HIV;HIV-1;Human Papillomavirus;Immune;Immune response;Immunity;immunogenicity;Immunotherapy;improved;In Vitro;in vivo evaluation;Interleukin-2;knock-down;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Measures;Mediating;Modeling;Modernization;Molecular Chaperones;mouse model;multicatalytic endopeptidase complex;Mus;nanoparticle;neoantigens;neutralizing antibody;Noise;novel;Oncoproteins;particle;peptide based vaccine;peptide vaccination;Peptide Vaccines;Peptides;Physiologic pulse;Plasmids;preclinical efficacy;Production;Proliferating;prophylactic;Protac;protein aminoacid sequence;Protein Binding Domain;protein degradation;Proteolysis;Proteolytic Processing;recruit;response;Role;Safety;secondary infection;Signal Transduction;small molecule;Splenocyte;Subunit Vaccines;System;T cell infiltration;T cell response;T-Cell Activation;T-Lymphocyte;Technology;Testing;therapeutic nanoparticles;tumor;Tumor Cell Line;tumor eradication;tumor growth;Tumor Specific Peptide;Ubiquitin;ubiquitin-protein ligase;Vaccination;Vaccine Adjuvant;vaccine development;vaccine platform;vaccine response;vaccine strategy;Vaccine Therapy;Vaccines;vaccinology;Validation;Virus;Virus Diseases

PROJECT_TITLE: Chaperoning epitopes to induce protective T cell responses

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: NEW HAVEN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will dissect the mechanisms regulating macrophage cell-cell heterogeneity and the emergence of macrophage subsets in healthy and diseased contexts. Knowledge of these mechanisms will enable future therapeutic targeting of macrophage dysregulation, such as occurs in chronic non-healing wounds and cancer.

PI_NAMEs: MILLER-JENSEN, KATHRYN  (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Adopted;Affect;Anti-Inflammatory Agents;Anti-viral Response;Behavior;Biological;Cell Communication;Cells;cellular targeting;Chronic;Complex;Cues;Data;density;Disease;Equilibrium;extracellular;fighting;Flow Cytometry;Future;Genetic Transcription;Heterogeneity;Homeostasis;Immune;in vivo;Individual;Infection;Inflammatory;Inflammatory Response;Innate Immune System;innovation;Interferon Type II;Interferons;Interleukin-4;Knowledge;Link;live cell imaging;Macrophage;Macrophage Activation;Malignant Neoplasms;Mammalian Cell;mathematical model;Measurement;Measures;Messenger RNA;Molecular;Natural Immunity;Noise;non-genetic;non-healing wounds;Paracrine Communication;pathogen;Physiologic pulse;Population;Population Density;programs;Proteins;Proteome;Public Health;recruit;Regulation;Research;response;Signal Transduction;single-cell RNA sequencing;System;Systems Analysis;Testing;Therapeutic;therapeutic target;Tissues;transcription factor;Transcriptional Activation;transcriptome;translational impact;translational potential;tumor;Variant;Work;wound healing

PROJECT_TITLE: Systems analysis of cell-to-cell variability and signaling-transcription factor motifs regulating macrophage responses to conflicting environmental cues

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Cannabidiol Research;Cannabinoid Research;Chronic Pain;Complementary and Integrative Health;Natural Products;Neurodegenerative;Neurosciences;Opioids;Pain Research;Peripheral Neuropathy;Therapeutic Cannabinoid Research

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Chronic pain affects up to 100 million people in the United States alone, and extended treatment of pain with opiates is one of the largest contributors to the current opioid crisis. Chemical compounds from the cannabis plant, including cannabidiol (CBD) and several terpenoids, show potential promise in the treatment of chronic pain, but the molecular mechanisms and long-term ramifications of cannabidiol/terpenoid treatment remain unknown. This proposal seeks to test whether long-term co-treatment of CBD and terpenoids is effective in managing chronic pain in experimental models, as well as where and how in the brain the pain-relieving effects of cannabidiol/terpenoids occurs.

PI_NAMEs: LAND, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: BELFER, INNA

PROJECT_TERMS: Absence of pain sensation;abuse liability;Acute;Acute inflammatory pain;Acute Pain;addiction;Affect;American;Amygdaloid structure;Analgesics;antagonist;antinociception;awake;Behavior;Behavioral;Benefits and Risks;Beta-caryophyllene;Biochemical;Biochemical Pathway;Biological Assay;Brain;Calcium;Cannabidiol;cannabinoid receptor;Cannabinoids;Cannabis;Cell Nucleus;Cells;Cellular Assay;central pain;Chemicals;Chronic;Chronic inflammatory pain;chronic neuropathic pain;chronic pain;chronic pain management;Clustered Regularly Interspaced Short Palindromic Repeats;CNR1 gene;CNR2 gene;combat;conditioned place preference;Consumption;Data;Dose;efficacy evaluation;efficacy testing;Euphoria;Experimental Models;experimental study;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Gelatin;Generations;Glutamates;Image;improved;In Vitro;in vivo;Inflammatory;inflammatory pain;Injections;insight;Ion Channel;Knock-out;knockout animal;lens;Ligation;linalool;MAPK8 gene;Measures;Mediating;Medical Marijuana;Mitogen-Activated Protein Kinases;Modeling;Molecular;Morphine;Mus;N-terminal;neural;Neurons;Neuropathy;Nociception;Non-Steroidal Anti-Inflammatory Agents;Opioid;opioid epidemic;opioid use;Oral;Pain;pain inhibition;Pain management;pain model;pain reduction;pain relief;pain score;painful neuropathy;Pathway interactions;Persons;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Pharmacology;Phosphotransferases;Physical Dependence;Physiological;phytocannabinoid;Plants;Population;preclinical study;prevent;Property;Proxy;Public Health;Reactive Oxygen Species;receptor;recruit;Regulation;Reporting;Research Personnel;response;Rewards;Risk;Role;sciatic nerve;sciatic nerve injury;Self Administration;sensor;side effect;Signal Pathway;Signal Transduction;Site;standard care;Substance abuse problem;System;Terpenes;Testing;Therapeutic;Time;Tissues;United States;United States National Institutes of Health

PROJECT_TITLE: Cannabidiol and terpenoid interactions in amygdalar regulation of pain states

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Neurosciences

ORG_CITY: SYRACUSE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: PROJECT NARRATIVE This grant proposes to interrogate the specific role(s) of PHF21B (plant homeodomain finger protein 21B) in neuronal function relevant to social recognition impairment; this is relevant because social cognitive impairments are a central feature of several neurodegenerative, neuropsychiatric, neurodevelopmental (e.g., autism spectrum and attention deficit hyperactivity disorder) conditions, and also occur following acute brain damage after traumatic brain injury and stroke. We present new evidence showing that mice with PHF21B deficiency have significant social memory deficits, characterized by significantly increased social novelty index when compared to wild-type animals; therefore, we propose to characterize the role of PHF21B in the hippocampus and to identify its target genes and regulatory mechanisms relevant to social memory. The results from the proposed studies will provide novel insights into the cellular and molecular mechanisms underlying epigenetic changes that affect social recognition memory and may facilitate the development of conceptually novel pharmacological targets to address social memory deficits.

PI_NAMEs: LICINIO, JULIO ;WONG, MA-LI  (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: Acetylcholine;Acute;Address;Affect;Animals;Attention deficit hyperactivity disorder;autism spectrum disorder;Binding;Brain Injuries;cholinergic;Cholinergic Receptors;Chromatin;Chronic stress;Data;Development;Disease;DNA Repair;epigenetic marker;Epigenetic Process;epigenetic regulation;Fingers;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;genome-wide;Glutamates;Goals;Grant;Hippocampus;histone demethylase;Histone H3;histone modification;Histones;homeodomain;Impaired cognition;Impairment;In Vitro;indexing;innovation;insight;knock-down;Learning;Manuscripts;Mediating;member;Memory;Memory impairment;memory recognition;Mental disorders;Methylation;Molecular;morris water maze;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurons;neuropathology;Neuropeptides;neuropsychiatric disorder;neuropsychiatry;neurotransmission;Nicotinic Receptors;novel;object recognition;Outcome;overexpression;Oxytocin;Oxytocin Receptor;pharmacologic;plant morphology;Plants;preference;Process;protein expression;Proteins;Reader;receptor;recruit;Regulator Genes;Reporting;Research;RNA Splicing;Role;Schizophrenia;Short-Term Memory;Signal Transduction;social;Social Behavior;social cognition;Social Functioning;Social Interaction;Stroke;Synapses;Synaptic plasticity;System;Testing;Time;Transgenic Mice;translational potential;Traumatic Brain Injury;treatment strategy;Vasopressins;Wild Type Mouse

PROJECT_TITLE: Dissecting the roles of an epigenetic regulator of genes involved in synaptic plasticity and social cognition.

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Microbiome;Neurosciences;Nutrition

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative/Public Health Relevance Recent efforts to understand the mechanisms underlying metabolic disease, revealed microglia as critical mediators of hypothalamic neuronal function in the regulation of both body weight and glucose control. Based on our recent findings, we propose to investigate the cellular and molecular mechanisms by which metabolites produced by the gut microbiota regulate microglial function in the mediobasal hypothalamus. This study will provide novel insights into microbiota-regulated molecular pathways in hypothalamic microglial cells relevant to body weight regulation and metabolic disease.

PI_NAMEs: VALDEARCOS, MARTIN  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Affect;Agonist;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Automobile Driving;blood glucose regulation;Blood Vessels;Body Weight;Brain region;Carbohydrates;Cells;Chromatin;Chronic;Consumption;Coupled;Data;Data Set;Diet;dietary;dietary excess;Eating;Embryo;epigenomics;Exhibits;Fermentation;FFAR2 gene;Gene Expression Profile;genetic approach;Germ-Free;glial activation;Goals;gut microbiota;Health;Heterogeneity;High Fat Diet;histone modification;Homeostasis;Hypothalamic dysfunction;Hypothalamic structure;Immune;Immunologics;imprint;Inflammatory;Inflammatory Response;insight;interest;Knowledge;Life;Ligands;Mediating;Mediator;Metabolic;Metabolic Control;Metabolic Diseases;microbial;microbiota;Microglia;microorganism;Molecular;Molecular Mechanisms of Action;Mucosal Immunity;multiple omics;Mus;Myeloid Cells;neonatal period;Neurons;new therapeutic target;novel;Obesity;Pathogenesis;Pathologic;Pathway Analysis;Pathway interactions;Peptide Initiation Factors;Peripheral;Phenotype;Population;Population Heterogeneity;postnatal;postnatal development;Predisposition;pregnant;prevent;Prevention;Process;Property;public health relevance;Publishing;pup;receptor;Receptor Signaling;Regulation;response;restraint;Role;Signal Transduction;single cell technology;Supplementation;Testing;Transcript;transcriptomics;Volatile Fatty Acids;Weaning;Weight Gain;Weight maintenance regimen;Work

PROJECT_TITLE: The microbiota-microglia axis in the regulation of metabolic homeostasis

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Autoimmune Disease;Diabetes

PHR: PROJECT NARRATIVE This project seeks to define the role of the efferocytic islet macrophages in regulating autoimmune diabetes. We place an emphasis on the efferocytosis process taking place in the pancreatic islets and aim to dissect the associated immunosuppressive elements. The anti-inflammatory effects will be evaluated in the model of autoimmune diabetes, to understand the key mechanisms leading to the protection from this disease.

PI_NAMEs: WAN, XIAOXIAO  (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Anti-Inflammatory Agents;Antigen Presentation Pathway;Antiinflammatory Effect;Apoptotic;Autoimmune;Autoimmune Diabetes;autoimmune pathogenesis;Autoimmune Process;Autoimmune Responses;Autoimmunity;autoreactive T cell;Beta Cell;Biological;Biology;Bystander Suppression;Cell Communication;Chronic;Complex;Development;diabetogenic;Disease;Elements;Environment;Event;Human;Immune;immunoregulation;Immunosuppression;Inflammatory Response;insight;Insulin;Insulin-Dependent Diabetes Mellitus;Invaded;islet;Islets of Langerhans;Macrophage;Mediating;Modeling;Molecular;Mus;Organ;Pathogenicity;prevent;Process;programs;Receptor Protein-Tyrosine Kinases;Regulation;Regulatory Element;Regulatory T-Lymphocyte;response;restraint;Role;Streptozocin;T cell infiltration;T-Lymphocyte;Therapeutic;Tissues

PROJECT_TITLE: Autoimmune Diabetes: Macrophage Responses

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Diabetes mellitus is a leading cause of morbidity in the United States, with diabetes and prediabetes together affecting more than 100 million individuals at an estimated cost of >300 billion dollars per year. Type 1 diabetes is caused by loss of the insulin-producing pancreatic β-cells. The proposed project will identify critical events that contribute to β-cell failure in Type 1 diabetes and therefore identify new targets for therapeutic diabetes interventions.

PI_NAMEs: LINNEMANN, AMELIA K (contact)

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: Adaptive Immune System;Affect;Antigens;Antioxidants;Apoptosis;Autoimmune Diabetes;autoimmune pathogenesis;Autoimmunity;Autophagocytosis;Autopsy;B-Cell Activation;B-Lymphocytes;Beta Cell;Cell Death;Cell Survival;Cells;Cellular biology;Cessation of life;Chemicals;Communication;cost estimate;Coupled;Couples;Coupling;cytokine;Data;Development;Diabetes Mellitus;diabetes pathogenesis;Diabetes prevention;diabetogenic;disorder prevention;Drug Delivery Systems;Etiology;Event;Excision;Exogenous Factors;experimental study;extracellular;Failure;Functional disorder;Future;Generations;Genetic Transcription;GLP-I receptor;Glucose;Homeostasis;Human;Immune;immune cell infiltrate;Immune System Diseases;Immune Tolerance;In Situ;In Vitro;in vivo;in vivo evaluation;Incidence;Indiana;Individual;Inflammatory;Insulin;insulin secretion;Insulin-Dependent Diabetes Mellitus;Interleukin 6 Receptor;Interleukin Activation;International;Intervention;intravital microscopy;islet;Laboratories;Lead;Link;Maintenance;Mediating;Metabolic Diseases;Methods;Mitochondria;mitochondrial autophagy;Molecular;Morbidity - disease rate;mouse model;Mus;nanoparticle;Nature;new therapeutic target;novel;Organelles;oxidative damage;Pancreas;Pathway interactions;Play;Population;Prediabetes syndrome;Predisposition;preservation;Process;Proteins;Proteomics;Reactive Oxygen Species;Receptor Signaling;Recycling;Regulation;Reporting;Research;Resources;response;restoration;Role;Secretory Cell;Signal Pathway;Signal Transduction;Streptozocin;Stress;Structure of beta Cell of islet;Testing;Therapeutic;therapeutic target;transcription factor;Transcriptional Activation;translational potential;United States;Work

PROJECT_TITLE: Autophagy/antioxidant response coupling in pancreatic beta-cell homeostasis regulation

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]


NIH_SPENDING_CATS: Aging;Neurosciences

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Microglia are non-neuronal cells in the CNS that can potently affect the function and integrity of neuronal synapses. Here, we will use novel approaches to study whether intracellular organelles called lysosomes can simultaneously regulate multiple microglial attributes that impact synapses, revealing new strategies for targeting these cells to preserve synaptic function throughout the lifespan. This work will determine how regional differences in microglial lysosome function during aging may contribute to regional differences in synapse loss and dysfunction, which are tied to age-related decline in movement and cognition and may increase risk of neurodegenerative disease.

PI_NAMEs: DE BIASE, LINDSAY MITCHELL (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Affect;age related;age related changes;age related decline;Aging;aging related;Autophagocytosis;Basal Ganglia;Behavior;Brain region;Calcium;Cell Nucleus;Cell Physiology;Cell Shape;Cells;Chemosensitization;CLN3 gene;Code;Cognition;cognitive function;confocal imaging;Data;Degenerative Disorder;density;Depressed mood;dopaminergic neuron;Electrophysiology (science);Excitatory Synapse;Exhibits;experimental study;Face;follow-up;functional decline;Functional disorder;functional status;Gene Expression;Genes;Goals;Health;Homeostasis;Image;Impaired cognition;Impairment;in vivo;Inflammation;Inflammatory;interdisciplinary approach;Knockout Mice;life span;Link;Lipids;Lipofuscin;Location;lysosome membrane;Lysosomes;Macrophage;Maps;Measures;Membrane;Methods;Microglia;middle age;Molecular;Molecular Target;Motility;Movement;Mus;Neurodegenerative Disorders;Neuroglia;Neurons;neuroprotection;Neurosciences;novel;novel strategies;Nucleus Accumbens;Organelles;overexpression;Parkinsonian Disorders;pars compacta;Pathway interactions;Peptide Hydrolases;Phagocytes;Phagocytosis;Phenotype;Play;Population;Positioning Attribute;preservation;Process;Production;Proliferating;Property;Proteins;Proton Pump;receptor;Recycling;regional difference;Regulation;response;Risk;Role;Shapes;Signal Transduction;single-cell RNA sequencing;Slice;Substantia nigra structure;Symptoms;Synapses;synaptic function;Synaptic plasticity;synaptogenesis;Testing;tissue fixing;transcriptome sequencing;Variant;Ventral Tegmental Area;virtual;Vulnerable Populations;Work;young adult

PROJECT_TITLE: Microglial lysosomes and selective neuronal vulnerability


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Clinical Research;Human Fetal Tissue;Immunotherapy

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE The immune system could recognize and eliminate cancers; however, tumors have the capacity to evade immune elimination by generating immunosuppressive microenvironments. Recently developed immunotherapies for cancer can overcome these tumors’ evasive actions and, in some cases, have led to durable, long-term survival; however these immunotherapies may also result in mild to severe inflammatory reactions and, in some instances, life-threatening autoimmunity. This project will apply new genetic tools to define the molecular mechanisms of these unwanted inflammatory adverse events and may propose approaches that may reduce the incidence and severity of these immune relate adverse events.

PI_NAMEs: MOR, ADAM  (contact);WINCHESTER, ROBERT J

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Address;Adverse event;Affinity;Alleles;Animal Model;anti-PD-1;Antibodies;Antigens;Arthritis;Autoimmune;Autoimmune Diseases;Autoimmunity;Automobile Driving;autoreactivity;Biology;Birth;Blood;cancer immunotherapy;cancer infiltrating T cells;Cancer Patient;cancer therapy;Cell Death;Cell Separation;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;checkpoint therapy;chemical property;chemokine;Clinic;Colon;comparative;CTLA4 blockade;Development;Disease;Disease susceptibility;Drug Targeting;Evolution;Exhibits;experimental study;Failure;Future;Genetic;Genomic DNA;Goals;Grant;Hematopoietic stem cells;Heterogeneity;Human;Immune checkpoint inhibitor;immune clearance;Immune Evasion;Immune response;Immune system;immune-related adverse events;Immunofluorescence Immunologic;Immunologic Markers;Immunophenotyping;Immunotherapy;Incidence;Infiltration;Inflammation;Inflammatory;inflammatory milieu;Inflammatory Response;Intervention;Joints;Life;Liver;Lung;Malignant Neoplasms;Mediating;Modeling;Molecular;mouse model;Mus;Musculoskeletal System;neoplastic cell;novel;Organ;Pancreas;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pattern;Peptides;peripheral tolerance;pre-clinical;Predisposition;prevent;Process;programmed cell death protein 1;Reaction;rituximab;Role;Severities;Stains;success;Susceptibility Gene;Syndrome;Synovial Fluid;T cell infiltration;T cell receptor repertoire sequencing;T-Cell Activation;T-cell receptor repertoire;T-Lymphocyte;T-Lymphocyte Subsets;Techniques;Testing;therapeutic target;Thymus Gland;tissue injury;Tissues;tocilizumab;tool;Toxic effect;tumor;Tumor Antigens;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;Variant;Work

PROJECT_TITLE: A systematic approach to uncover the basic mechanisms of checkpoint inhibitor immune related adverse events

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIO-D(01)Q]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Heart Disease - Coronary Heart Disease;Neurosciences

ORG_CITY: PROVIDENCE

ORG_NAME: MIRIAM HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE Takotsubo syndrome (TS) is increasingly recognized in clinical settings and is associated with considerable long-term cardiovascular morbidity and mortality. Several important gaps in our knowledge of the pathophysiology of TS limit our ability to effectively treat and prevent this condition. Understanding whether heterogeneity in triggers and stress reactivity may play a role in the pathophysiology and prognosis of TS will provide the rationale for the design and testing of properly targeted interventions to improve prognosis for this important patient group.

PI_NAMEs: SALMOIRAGO-BLOTCHER, ELENA  (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Accounting;Acute;acute coronary syndrome;Address;Admission activity;Affect;age group;Area;Arrhythmia;Articulation;Autonomic nervous system;Cardiac;Cardiovascular system;Catecholamines;cerebrovascular;Chronic;Clinical;Clinical Trials;clinically relevant;Consensus;coronary lesion;data registry;design;Diagnosis;Disease;Echocardiography;Electrocardiogram;Elements;Emotional;Enzymes;Evaluation;Event;Exposure to;follow-up;Functional disorder;Functional impairment;Health;Heart Atrium;heart function;hemodynamics;Heterogeneity;high risk;Hospitals;Impairment;improved;indexing;Individual;innovation;Intervention;Interview;Ischemia;Knowledge;Laboratories;Left Ventricular Function;life span;Link;Measures;Medical;Medical center;Methods;Modeling;Morbidity - disease rate;mortality;Myocardial Ischemia;National Heart, Lung, and Blood Institute;older women;Outcome;Participant;Pathway interactions;Patient Admission;patient prognosis;Patients;Persons;Physiological;Physiology;prevent;Prognosis;Protocols documentation;Psyche structure;psychologic;psychosocial;Questionnaires;Recovery;recruit;Research Methodology;Research Priority;response;Stress;Stress cardiomyopathy;stress reactivity;Subgroup;Survivors;Sympathetic Nervous System;Symptoms;Syndrome;Systolic heart failure;Testing;Ventricular;Ventricular Function;Visit

PROJECT_TITLE: Heterogeneity and predictors of stress reactivity in takotsubo syndrome

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Lung;Pulmonary Fibrosis;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PHR: PROJECT NARRATIVE Fibrotic lung diseases represent a largely intractable set of disorders accompanied by progressive morbidity and mortality. The cytokine TGFβ1 is the master driver of fibrotic disease but likely also deters effective lung regeneration after major injury. This program is directed at identifying and bringing to the clinic pathways to both attenuate fibrosis and concurrently improve lung regeneration.

PI_NAMEs: CHAPMAN, HAROLD A (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Alveolar;Animal Model;Attenuated;Automobile Driving;Biopsy;Cells;Clinic;Clinical Trials;cytokine;Data;Diagnostic;Dimensions;Disease;Environment;Epigallocatechin Gallate;epithelial injury;epithelial stem cell;Epithelium;epithelium regeneration;Failure;Fibroblasts;fibrogenesis;Fibrosis;fibrotic lung disease;Functional disorder;Funding;Future;Goals;Health;Human;improved;in vivo;inhibitor;Injury;LOXL2 gene;Lung;Lung fibrogenesis;lung regeneration;Lung Transplantation;Mesenchymal;molecular imaging;Morbidity - disease rate;mortality;Mus;Natural regeneration;novel therapeutic intervention;Organoids;Pathway interactions;Patients;Process;progenitor;programs;Pulmonary Fibrosis;Research;resilience;single-cell RNA sequencing;small molecule;stem;stem cells;Testing;Time;tissue biomarkers;Tissues;Transforming Growth Factor beta;Type II Epithelial Receptor Cell

PROJECT_TITLE: Program to promote lung regeneration and block fibrosis


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Drug Abuse (NIDA only);Emerging Infectious Diseases;Infectious Diseases;Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

PHR: Project narrative The Adolescent Brain and Cognitive Development (ABCD) study is a longitudinal study of unprecedented size and scope, with the potential to transform understanding of the neurobiology of substance-use risk. However, individuals in this cohort face a unique developmental challenge—entering adolescence during the COVID-19 pandemic. This application leverages recent advances in Bayesian machine learning to carefully delineate neurodevelopmental trajectories of substance use risk with specific consideration of the societal and individual effects of COVID-19 using longitudinal data from ABCD (ages 10-14, N>10,000).

PI_NAMEs: BZDOK, DANILO ;YIP, SARAH  (contact)

PROGRAM_OFFICER_NAME: PARIYADATH, VANI

PROJECT_TERMS: Acceleration;Address;Adolescence;Adolescent;Adoption;Age;Bayesian learning;Bayesian Modeling;Bayesian Prediction;Behavioral;Brain;Cessation of life;Child;Child Development;Child Health;Cities;clinical practice;cognitive development;cohort;Collaborations;Communities;Complex;complex data;Corpus striatum structure;course development;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Aggregation;Data Collection;Data Set;Development;Dietary Fiber;early onset substance use;Economics;Event;Exhibits;experience;Face;Family history of;Fingerprint;flexibility;Functional Magnetic Resonance Imaging;Future;Generations;Geographic Locations;Growth;Healthcare Systems;Height;Home environment;Hospitalization;Individual;Individual Differences;Infection;insight;interest;Joints;Laboratories;Life;Life Style;Linear Regressions;Logistics;Longitudinal Studies;Measurable;Measures;Modeling;neural;Neurobiology;neurodevelopment;Neurosciences;novel;Outcome;pandemic disease;pandemic impact;Participant;Patients;perceived stress;Phenotype;Population;predictive modeling;preventive intervention;Probability;Process;Psychiatry;psychosocial;Psychosocial Stress;Public Health;Recording of previous events;Recreation;repository;Reproducibility;Research;response;Rewards;Risk;Role;school closure;Series;Site;social;Social Distance;social media;Source;Statistical Models;Structure;substance use;Substance Use Disorder;System;Thalamic structure;theories;Time;tool;Uncertainty;Unemployment;United States;Variant;Youth

PROJECT_TITLE: Application of a Bayesian strategy to ABCD: Identification of substance use risk and COVID-19 effects on neurodevelopment

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: Project Narrative The goal of this research is to understand the development and maintenance of the colon epithelial layer, which lines the final segment of the human digestive track. Many diseases, ranging from inflammatory bowel disease to colon cancer involve the misregulation of colon differentiation and growth, yet little is known about colon development. Thus, better understanding the requirements for proper regulation will yield new strategies for treating diseases of the colon.

PI_NAMEs: KLEIN, OPHIR D (contact);LIM, WENDELL A

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Adult;base;Bioinformatics;Biology;Cell Differentiation process;Cells;Characteristics;Coculture Techniques;collaborative environment;Colon;Colon Carcinoma;Colon Injury;colonic crypt;Colonic Diseases;Colorectal Cancer;Communication;comparative;Development;Differentiation and Growth;Disease;Embryo;Engineering;Epithelial Cells;Epithelium;epithelium regeneration;Event;Fibroblasts;Gastrointestinal tract structure;Gene Modified;Genetic;genetic approach;Genetic Transcription;Goals;Health;Histologic;Homeostasis;Human;human disease;In Vitro;in vitro Model;in vivo;Inflammatory Bowel Diseases;inhibitor;Injury;interest;intestinal crypt;intestinal epithelium;Knowledge;Maintenance;Maps;Mesenchymal;Mesenchyme;Modeling;Molecular;Morphogenesis;Morphology;mouse model;Mucous Membrane;Mus;Natural regeneration;Organoids;Pathology;Pattern;Play;Population;Principal Investigator;Productivity;progenitor;programs;reconstitution;regenerative;Regulation;Research;Role;Shapes;Signal Transduction;single-cell RNA sequencing;Site;Small Intestines;spatiotemporal;spheroids;stem;stem cells;Structure of intestinal gland;synthetic biology;System;Testing;Therapeutic;transcriptomics;Undifferentiated;Villus;WNT Signaling Pathway;Work

PROJECT_TITLE: How Patterned Mesenchymal-Epithelial interactions Shape Intestinal Crypts

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Diabetes;Prevention

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: PROJECT NARRATIVE Persons with diabetes often experience life-threatening periods of low blood sugar or hypoglycemia. These hypoglycemic episodes make clinical management of blood sugar in diabetes patients challenging. This research seeks to better understand why diabetes patients develop hypoglycemia, and what can be done to prevent it.

PI_NAMEs: MCDOUGAL, DAVID HARRY (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Acute;Address;Adipose tissue;Adrenergic Agents;Alcohol consumption;Alcohols;animal tissue;Automobile Driving;Behavior Therapy;Blood Glucose;Clinical;Clinical Management;cold temperature;Corticotropin-Releasing Hormone Receptors;counterregulation;Data;design;Diabetes Mellitus;druggable target;Dyslipidemias;efficacious treatment;Endocrine;Event;Exercise;Exposure to;FDA approved;Genetic;Glucose;glycemic control;Goals;Homeostasis;Hormones;Human;Hypoglycemia;Iatrogenesis;Impairment;improved outcome;Intervention;Knowledge;Leptin;Life Experience;Mediating;Metabolic;nerve supply;novel;Patients;permissiveness;Persons;pharmacologic;Phenotype;Physiological;pre-clinical;Predisposition;prevent;Prevention;receptor;Recombinants;Recurrence;Research;Research Personnel;response;Risk;Risk Factors;Role;Series;Signal Transduction;Starvation;Stimulus;Strenuous Exercise;Testing;Treatment Protocols;Work

PROJECT_TITLE: Evaluating the role of hypoleptinemia in impaired counterregulatory responses to hypoglycemia


NIH_SPENDING_CATS: Congenital Structural Anomalies;Pediatric;Urologic Diseases

ORG_CITY: WASHINGTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative This study is relevant to public health because it is focused on generating knowledge on immune cells in the prostate. Results from this study have the potential to inform the development of improved treatment strategies for prostate diseases including benign prostatic hyperplasia (BPH). Thus, the proposed research is relevant to the NIDDK mission of advancing scientific knowledge to improve disease treatment for urologic disease.

PI_NAMEs: SHIBATA, MAHO  (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Adoptive Transfer;Adult;Affect;Androgen Receptor;Androgens;Benign;Benign Prostatic Hypertrophy;Birth;Bone Marrow;Cell Physiology;cell type;Cells;Data;Dependence;Development;diphtheria toxin fragment A;Discipline;Disease;effective therapy;Embryo;Epithelial Cells;fetal;Fetal Liver;Foundations;Generations;Genes;Genetic;Goals;Growth;Heterogeneity;Histologic;hormone regulation;Human;Image;Immune;Immune system;Immune System Diseases;Immune Targeting;Immunofluorescence Immunologic;immunoregulation;Immunosuppression;improved;in vivo;innovation;innovative technologies;insight;Investigation;Knowledge;Lung;Macrophage;Mammary gland;men;Mission;monocyte;Morphogenesis;mouse model;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;novel;novel strategies;Nuclear;Organ;Organogenesis;Organoids;Population;Population Heterogeneity;Property;Prostate;Prostatic Diseases;Proteins;Puberty;Public Health;Publishing;receptor expression;receptor function;Regulation;Reporter;reproductive;Research;research study;Resolution;response;Role;Scientific Advances and Accomplishments;Signal Transduction;single-cell RNA sequencing;Specificity;Testing;Testis;Therapeutic;Three-Dimensional Imaging;Tissues;treatment strategy;tumor-immune system interactions;Urologic Diseases;Yolk Sac

PROJECT_TITLE: Regulation of prostate organogenesis by tissue-resident macrophages

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative  Our understanding of mutations in disease genes has advanced remarkably in recent years, but our ability to interpret the effects of mutations in cis-regulatory elements (CREs) that turn genes on and off remains rudimentary. In this proposal we will develop a strategy for the identification of mutations in CREs that may predispose to neuropsychiatric disease. In this way, we will pave the way for better and more precise genetic diagnosis in patients suffering from these disorders.

PI_NAMEs: CORBO, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Acceleration;Address;adenovirus mediated delivery;Affect;autism spectrum disorder;Bar Codes;Behavioral;Binding;Binding Sites;Biological Assay;Bipolar Disorder;Brain;candidate identification;Catalogs;causal variant;Cerebral cortex;Cerebrum;Chromatin;cognitive performance;Complement;Data;Dependovirus;Development;Disease;disorder risk;DNA;Electroporation;Enhancers;Evaluation;falls;Gene Expression;General Population;Genes;genetic disorder diagnosis;genetic variant;genome wide association study;genome-wide;genome-wide analysis;Genomic Segment;Genotype-Tissue Expression Project;Goals;Human;human data;Human Genetics;Human Genome;human induced pluripotent stem cells;in utero;in vivo;Individual;Libraries;Linkage Disequilibrium;Location;Maps;Measures;Mediating;Mus;Mutation;Neuroglia;Neurons;neuropsychiatric disorder;neuropsychiatry;Nucleotides;Organoids;Patients;Persons;Process;promoter;Prosencephalon;Protein Microchips;Proteins;rare variant;Regulatory Element;Reporter;Reporter Genes;Rodent;Schizophrenia;Techniques;Technology;Time;Tissues;trait;Transcript;transcription factor;transcriptome sequencing;Untranslated RNA;Variant

PROJECT_TITLE: High-throughput identification of causal variants underlying neuropsychiatric disease-related GWAS hits

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: WINSTON-SALEM

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: HEALTH RELEVANCE  Oxidative damage is considered important in aging, in the development of cancer and in many degenerative diseases. Moreover, impairments in cell signaling processes controlling proliferation, differentiation and apoptosis are associated with many disease states. An enhanced understanding of peroxide-scavenging enzymes known as peroxiredoxins (Prxs) and the roles they play in both cell signaling and antioxidant protection will thus have important implications for the prevention of human diseases. Notably, enhanced Prx expression in tumors can impart radation resistance to these cells. In addition, the role of Prxs in protecting human pathogens against killing by the immune system implicates Prxs as targets for the development of new therapeutic agents to combat infectious diseases.

PI_NAMEs: POOLE, LESLIE B (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Acetylation;Active Sites;Aging;Antioxidants;Apoptosis;Area;Biophysics;Cell Cycle Regulation;Cell Signaling Process;Cells;Chemicals;Collaborations;combat;Communicable Diseases;Cysteine;cytokine;Data;Degenerative Disorder;Development;Disease;Effectiveness;Enzymatic Biochemistry;Enzymes;Eukaryota;Excision;Family;follow-up;Future;Growth Factor;Health;Hot Spot;Human;human disease;human pathogen;Hydrogen Peroxide;Immune system;Impairment;Infectious Agent;insight;Intervention;KRAS2 gene;Malignant Neoplasms;Mediating;Medical;mutant;NADPH Oxidase;nitration;novel therapeutics;Organism;Oxidants;oxidation;Oxidation-Reduction;oxidative damage;Paper;Peroxidases;Peroxides;peroxiredoxin;Phosphorylation;Play;Post-Translational Protein Processing;Prevention;Proliferating;Proteins;Publishing;receptor internalization;Regulation;Research Personnel;Resistance;response;Role;Science;Second Messenger Systems;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Source;spatiotemporal;structural determinants;Structure;Sulfenic Acids;System;Therapeutic Agents;tool;Toxin;tumor;TXN gene;Work

PROJECT_TITLE: Redox Regulation of Cysteine-Dependent Peroxidases and Signal Transduction Pathways

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-G(55)R]


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Public Relevance: The PIKE PREP is designed to enhance the scientific education and research experience of underrepresented minority postbaccalaureates with the goal of increasing the number of students that become accepted into and complete biomedical-related Ph.D. or M.D.-Ph.D. programs and careers.

PI_NAMEs: DAVILA, EDUARDO V (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Acute;Address;African American;Alaska Native;American Indians;Area;Basic Science;Behavioral Sciences;Belief;Biomedical Research;Black American;career;career development;cohesion;Colorado;Communication;Communities;community building;Complement;Critical Thinking;Critiques;Data Analyses;Dedications;design;Development Plans;Dimensions;disability;disadvantaged background;Doctor of Medicine;Doctor of Philosophy;doctoral student;Education;Educational workshop;Enrollment;Ensure;Environment;Evaluation;Event;Evidence based practice;experience;Face;Faculty;faculty mentor;Fostering;Foundations;Goals;graduate school;graduate student;Grant;Hispanic;improved;Individual;innovation;interest;Interview;Knowledge;Laboratories;Laboratory Research;Latino;Lead;Leadership;Medical;Mental Health;Mentors;Mentorship;minority health disparity;Monitor;Native Hawaiian or Other Pacific Islander;Oral;Population;Postbaccalaureate;Postdoctoral Fellow;posters;Preparation;Process;Productivity;programs;Qualifying;Research;Research Design;Research Personnel;Research Project Grants;Research Training;Resources;Role;role model;Science;Self Efficacy;skills;social;Structure;Students;success;Technical Expertise;Training;Translational Research;Underrepresented Minority;underrepresented minority student;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: Colorado Preparation in Interdisciplinary Knowledge to Excel PREP

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ORG_DEPT: CHEMISTRY

PHR: The UW PREP program contributes to enhancing the diversity of the biomedical research community by annually recruiting seven fellows from a pool of recent graduates belonging to groups underrepresented in the biomedical sciences to prepare them for successful application to and graduation from first-rated biomedical pre-doctoral programs. The fellows will engage in a year-long intensive research project and receive professional training in scientific writing, public presentations and scientific communication and in the bioethical conduct of research. All fellows will apply for admission to multiple PhD or MD/PhD programs during their tenure in the program, with the goal that at least 75% of them will be accepted into pre-doctoral program and at least 75% of these will graduate with a doctoral degree, as was accomplished in the first two funding periods.

PI_NAMEs: VARANI, GABRIELE  (contact)

PROJECT_TERMS: Admission activity;Advisory Committees;Bioethics;Biomedical Research;biomedical scientist;Caliber;career;Committee Members;Communication;Communities;Dedications;design;Development;disability;disabled;disadvantaged background;disadvantaged student;Doctor of Medicine;Doctor of Philosophy;Doctor's Degree;doctoral student;economic disparity;education research;Effectiveness;Enrollment;Ethnic Origin;Evaluation;Evaluation Reports;Evaluation Research;experience;Faculty;faculty mentor;Fellowship;Fostering;Foundations;Fred Hutchinson Cancer Research Center;Funding;Goals;graduate school;graduate student;Graduation Rates;Group Meetings;improved;Individual;Instruction;Interview;Journals;Laboratories;laboratory experience;Laboratory Research;Leadership;Literature;Master of Science;Measures;meetings;member;Mentors;Mentorship;Monitor;Oral;Pattern;Population;Postbaccalaureate;Postdoctoral Fellow;posters;pre-doctoral;Preparation;Program Development;programs;Public Health;Qualifying;Records;recruit;Research;Research Personnel;Research Project Grants;Running;Science;Scientist;skills;social;Students;success;Supervision;symposium;Testing;Training;training opportunity;Training Programs;Training Support;undergraduate research;undergraduate student;underrepresented minority student;Underrepresented Populations;United States National Institutes of Health;Universities;Washington;Writing

PROJECT_TITLE: UW Post-Baccalaureate Research Education Program (PREP)

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: Project narrative This project will explore the mechanisms by which the kidney reabsorbs magnesium, an essential nutrient. The link between handling of magnesium and potassium by the kidney will also be studied, since the processes involved can be disrupted by medications or genetic diseases.

PI_NAMEs: MCCORMICK, JAMES A (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: absorption;Acute;Affect;Amiloride;Apical;apical membrane;Atrophic;Automobile Driving;Cell Physiology;chemotherapy;Chronic;Cisplatin;Clinical;cofactor;Coupled;Data;Dietary Magnesium;Dietary Potassium;Disease;Disinhibition;Distal;Distal convoluted renal tubule structure;Diuretics;Electrolytes;epithelial Na+ channel;Etiology;Excretory function;Experimental Models;Functional disorder;Gene Expression;Genetic;Genetic Diseases;Gitelman syndrome;Homeostasis;Human;hyperkalemia;Hypertension;Hypokalemia;Hypomagnesemia;KCNJ1 gene;Kidney;Knockout Mice;Knowledge;Life;Limb structure;Link;Magnesium;Magnesium Deficiency;Measures;Membrane Potentials;Mg supplementation;Missense Mutation;mouse model;Movement;Mus;Mutation;Na(+)-K(+)-Exchanging ATPase;Nephrons;non-genetic;Normal Range;novel;Nutrient;Optics;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiological;Plasma;Play;Potassium;Potassium Channel;preservation;Process;Recycling;Refractory;Renal clearance function;Renal tubule structure;response;Rest;Role;Serum;Site;SLC12A3 gene;Structure;Supplementation;symporter;Syndrome;Testing;thiazide;Thiazide Diuretics;Thick;Three-Dimensional Imaging;Time;Tissues;urinary;wasting

PROJECT_TITLE: Magnesium handling by the distal nephron


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Genetic Testing;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Prevention;Schizophrenia;Serious Mental Illness

ORG_CITY: DANVILLE

ORG_NAME: GEISINGER CLINIC

ORG_STATE: PA

PHR: PROJECT NARRATIVE Developmental and psychiatric disabilities, including autism, schizophrenia, and bipolar disorder, impact the health, functioning, and quality of life of millions of individuals and their families. Genetic causes of these conditions are being discovered at a rapid rate, yet there are many unanswered questions about the wide and variable range of symptoms and outcomes seen in people who have these genetic disorders. We propose a comprehensive and novel strategy to accelerate the detection and description of genetic causes of brain disorders, including the identification of additional factors in a person’s genetic (familial) background that contribute to their risk or resilience for developing mental health conditions.

PI_NAMEs: LEDBETTER, DAVID H.;MARTIN, CHRISTA LESE (contact)

PROJECT_TERMS: Acceleration;Algorithms;autism spectrum disorder;base;Behavioral;behavioral phenotyping;Biological;Bipolar Disorder;Blinded;Brain;Brain Diseases;Cardiovascular Diseases;Classification;Clinic Visits;Clinical;clinical care;clinical risk;Cognitive;cohort;comorbidity;Copy Number Polymorphism;Data;Detection;Development;Developmental Disabilities;Diagnosis;Diagnostic;Disclosure;Disease;disorder risk;Early Diagnosis;Electronic Health Record;Etiology;evidence base;exome;falls;Family;Gene Dosage;General Population;Genes;Genetic;genetic counselor;Genetic Diseases;Genetic Predisposition to Disease;genetic testing;genetic variant;Genomic Segment;Genomics;Goals;Grain;Health;Healthcare Systems;high risk;improved;Individual;Inherited;innovation;Investigation;Link;Malignant Neoplasms;Manuals;Maps;Measurable;Measures;Medical;Medical Genetics;Mental disorders;Mental Health;Methodology;Methods;Modeling;Morbidity - disease rate;National Institute of Mental Health;Neurodevelopmental Disorder;Neurologic;novel;novel strategies;Outcome;Participant;Pathogenicity;Patients;Penetrance;Persons;phenome;Phenotype;population based;Prevalence;Prevalence Study;Prevention;promote resilience;prospective;psychiatric disability;Quality of life;rare variant;recruit;Research;research study;resilience;Risk;Risk Estimate;risk prediction;Role;Sampling;Schizophrenia;schizophrenia risk;Single Nucleotide Polymorphism;SNP genotyping;Strategic Planning;Structure;Surveys;Symptoms;telehealth;Testing;trait;Uncertainty;United States National Institutes of Health;Variant;variant of unknown significance

PROJECT_TITLE: Gene Dosage Imbalance in Neurodevelopmental Disorders

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: SALT LAKE CITY

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Most of the genes mutated in human genetic diseases are found in model organisms, but researchers lack the tools to manipulate the genes efficiently. By developing high-throughput methods to modify genomes, we will expand the speed and precision to test models for gene function and misfunction in humans.

PI_NAMEs: JORGENSEN, ERIK M (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Acceleration;Amino Acid Motifs;Animals;Biochemical;Biological Assay;Biological Models;Biology;C. elegans genome;Caenorhabditis elegans;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Collection;Communities;Computer software;cost;cost effective;design;Disease;DNA;DNA cassette;DNA Integration;Engineering;Event;Excision;experience;experimental study;Freezing;Future;gene function;Gene Modified;Gene Targeting;Generations;Genes;Genetic;Genetic Diseases;genetic manipulation;Genetic Recombination;Genome;genome editing;Genome engineering;genomic tools;Genomics;Germ Lines;Goals;Guide RNA;Hand;Human;Human Genetics;improved;Individual;Injections;Laboratories;Libraries;Location;Measures;Methods;model organism;Modeling;Modification;Molecular;Molecular Biology;Mutate;Nematoda;novel;Oligonucleotides;Organism;Phenotype;Process;Proteins;Proteome;Random Allocation;rapid technique;Reaction;Reagent;recombinase;recombinase-mediated cassette exchange;repaired;Research Personnel;Series;Signal Pathway;Site;software development;Software Tools;Speed;Structure;Testing;Time;tool;Transgenes;Work;Writing

PROJECT_TITLE: Genome engineering in the nematode C. elegans

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Infant Mortality;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS ENGINEERING EXPERIMENT STATION

ORG_STATE: TX

PHR: PROJECT NARRATIVES Spontaneous preterm birth (PTB<37 weeks of gestation) is a major pregnancy complication, and infectious or non-infectious inflammation contribute to over 70% of all PTB and neonatal morbidities. Here we propose to develop, validate, and utilize a disease model of PTB by recreating feto-maternal (F-M) uterine tissues on an organ-on-chip (OOC) device, to test the efficacy of an anti-inflammatory drug delivered via extracellular vesicles in reducing PTB risk by diminishing inflammation. The F-M interface OOC model will recapitulate both the fetal and maternal side of the F-M interface in terms of their structure and functions, the fetal and/or maternal side inflammation models faithfully represent the propagation of inflammation predisposing to PTB, and be used to test whether potential therapeutic molecules suppress inflammation in each layer of the F-M interface.

PI_NAMEs: HAN, ARUM  (contact);MENON, RAMKUMAR

PROGRAM_OFFICER_NAME: HARGROVE, PASSLEY R

PROJECT_TERMS: 37 weeks gestation;Address;African American;amnion;Animal Model;Anti-Inflammatory Agents;Biological Process;Birth;Birth Rate;Cell membrane;Cell Physiology;Cells;Cervix Uteri;Clinical Trials;Coculture Techniques;cost;Decidua;Devices;Disease;disease model;drug mechanism;efficacy testing;engineered exosomes;Ensure;Environment;Etiology;extracellular vesicles;fetal;Fetal Membranes;Fetus;Future;Gender;Goals;Growth;Health Care Costs;healthy pregnancy;Heterogeneity;Homeostasis;Human;I Kappa B-Alpha;I-kappa B Proteins;Immune;immune cell infiltrate;Immune response;in utero;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;inhibitor;innovative technologies;Laboratories;Lead;Lipopolysaccharides;male;Maternal-Fetal Exchange;Mediator;Membrane;microbial;migration;model design;Modeling;mouse model;Mus;neglect;neonatal morbidity;Neonatal Mortality;neonate;NF-kappa B;nonhuman primate;novel;novel therapeutics;Nutrient;Organ;organ on a chip;Oxidative Stress Induction;Pathologic;Patients;personalized care;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;Physiological;Pilot Projects;Placenta;preclinical trial;Pregnancy;Pregnancy Complications;Pregnancy Maintenance;premature;Premature Birth;Premature Labor;Prevention strategy;Process;Property;Race;racial diversity;Reporting;Research;response;Risk;Risk Factors;Sampling;Side;side effect;stem cells;Structure;success;System;Teratogens;Testing;Therapeutic;therapeutic candidate;therapeutic development;therapy design;Tissue Microarray;Tissues;Toxic effect;trafficking;Transgenic Mice;trophoblast;United States;Uterine Contraction;Uterus

PROJECT_TITLE: Developing extracellular vesicle based therapeutics against pre-term birth through the use of maternal-fetal interface on a chip


NIH_SPENDING_CATS: Complementary and Integrative Health;Data Science;Dietary Supplements;Networking and Information Technology R&D (NITRD);Nutrition

ORG_CITY: MINNEAPOLIS

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Built upon our prior project, the objective of this renewal application is to create an enriched DS knowledge base (eDISK) and to develop a translational informatics framework (iDSIK-Mine) with innovative informatics approaches to facility DS research using real-world, multi-site EHR data. This is the first project to develop a translational informatics framework to advance our DS knowledge using multimodal data sources. The successful accomplishment of his project will deliver a novel informatics framework with valuable tools and resources for identifying DS efficacy and safety from multimodal data sources, and enable us to understand how patients (e.g., depression patients) use DS using the real-world EHR data.

PI_NAMEs: ZHANG, RUI  (contact)

PROGRAM_OFFICER_NAME: HOPP, CRAIG

PROJECT_TERMS: Adult;Adverse event;Clinic;Clinical;Clinical Research;cohort;Complementary Health;Computing Methodologies;Data;data modeling;data repository;Data Set;Data Sources;dietary supplements;Disease;Education;efficacy testing;Electronic Health Record;Emergency department visit;evidence base;experience;Food;Foundations;Funding;Goals;Health;Health Personnel;Hospitalization;improved;individual patient;Informatics;informatics tool;innovation;Institution;Integrative Medicine;Knowledge;knowledge base;knowledge graph;lexical;Link;Literature;Manufacturer;Marketing;Mental Depression;Methods;Mining;multimodal data;National Center for Complementary and Integrative Health;Natural Language Processing;novel;nutrition;online resource;Ontology;open source;Patient risk;Patients;Peer Review;Pharmaceutical Preparations;post-market;Publications;Reporting;Research;Resources;Safety;Semantics;Site;social media;Strategic Planning;Surveys;System;Terminology;tool;Translational Research;Treatment Failure;Unified Medical Language System;United States Food and Drug Administration;Work

PROJECT_TITLE: A Translational Informatics Framework to Mine Efficacy and Safety of Dietary Supplements

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: The results of the proposed study will begin to elucidate the link between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) exposure, central and peripheral inflammation in pregnancy, and psychiatric and cognitive sequelae postpartum. We will identify central and peripheral markers of subacute and long-term neuropsychiatric sequelae of SARS- CoV-2. The results of this study will have important implications for mental health in the vulnerable periods of pregnancy and postpartum, and will identify targets for personalized treatment to ameliorate long-term neuropsychiatric sequelae of Coronavirus Disease-19 (COVID-19) and other infections.

PI_NAMEs: DE WITTE, LOTJE DOROTHEE;PEREZ RODRIGUEZ, MARIA DE LAS MERCEDES  (contact)

PROGRAM_OFFICER_NAME: LAWHORN, COLLENE

PROJECT_TERMS: 2019-nCoV;Acute;Age;Antibodies;Attention;Autoantibodies;Autoimmune Process;Blood;Blood specimen;Central Nervous System;Cerebrospinal Fluid;Cognition;Cognitive;Cognitive deficits;cognitive performance;cognitive testing;cohort;Cohort Studies;COVID-19;COVID-19 sequelae;Data;Development;Diagnostic;Dimensions;Exclusion;executive function;Exposure to;fetal;Funding;General Population;Generations;Goals;high risk;Immunoassay;Immunoglobulin G;Impaired cognition;Infection;Inflammation;Inflammatory;inflammatory marker;Link;long term consequences of COVID-19;Long-Term Effects;Longitudinal Studies;Measures;Mediating;Mediator;Memory;Mental Health;Neurons;neuropsychiatric sequelae of COVID-19;neuropsychiatric symptom;neuropsychiatry;New York;Nucleocapsid;Outcome;pathogen;Performance;Peripheral;personalized medicine;Phenotype;post SARS-CoV-2 infection;Postpartum Depression;postpartum outcome;Postpartum Period;Postpartum Women;Pregnancy;Pregnant Women;Process;psychiatric symptom;reproductive;Risk Factors;Role;Sampling;SARS-CoV-2 antibody;SARS-CoV-2 exposure;SARS-CoV-2 infection;Vaccination;Vulnerable Populations;Woman

PROJECT_TITLE: Cerebrospinal fluid (CSF) and peripheral markers of the neuropsychiatric sequelae of COVID-19: The Generation C-SF pregnancy study


NIH_SPENDING_CATS: Autism;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: GABAergic dysfunction is strongly associated with autism, schizophrenia and childhood epilepsy. Increasing experimental evidence points towards imbalances between the excitatory and inhibitory circuits in the brain as a prominent component in the etiology of these illnesses. This project is aimed at further our understanding on how electrical activity affects early brain maturation during critical periods of development with an emphasis on interhemispheric circuits for sensory integration.

PI_NAMEs: DE MARCO GARCIA, NATALIA VANESA (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Adolescent;Adult;Affect;Area;ASD patient;autism spectrum disorder;barrel cortex;Behavior;Behavioral;Brain;brain abnormalities;Brain Diseases;Calcium;Cells;Cerebral cortex;chemokine;childhood epilepsy;Cortical Column;critical period;Defect;Development;Developmental Process;Disease;Distal;Emergency Situation;Epilepsy;Equilibrium;Etiology;excitatory neuron;Functional disorder;gamma-Aminobutyric Acid;genetic approach;Goals;hippocampal pyramidal neuron;Human;Image;Impairment;in vivo;in vivo calcium imaging;inhibitory neuron;innovation;insight;Interneuron function;Interneurons;Knowledge;Lasers;Lateral;Lead;Ligands;maladaptive behavior;Microscopy;Mus;Mutant Strains Mice;Neonatal;neonate;Nervous System Disorder;neurological pathology;neuromechanism;Neurons;neurotrophic factor;Outcome;Output;Perinatal;perinatal development;Photons;Population;postnatal;postnatal development;Process;pup;recruit;Research;Rest;Role;Scanning;Schizophrenia;sensor;Sensory;Sensory Deprivation;sensory integration;Shapes;somatosensory;Somatosensory Cortex;Study models;System;Techniques;Testing;Thalamic structure;translational impact;two-photon;Vibrissae;Work

PROJECT_TITLE: Neural Mechanism for the assembly of GABAergic in the cerebral cortex

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR-M]


NIH_SPENDING_CATS: Aging;Biotechnology;Regenerative Medicine;Sarcopenia;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: TAMPA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE The ability of the resident muscle stem cells to maintain and repair skeletal muscle declines progressively in the elderly and severely affect muscle strength, mobility and quality of life. The current application will develop novel strategies using induced pluripotent stem cell derived muscle progenitors and their extracellular vesicles to reverse the senescence process of muscle stem cells and to enhance the therapeutic efficacy of stem cells for the treatment of sarcopenia.

PI_NAMEs: XUAN, WANLING  (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Acceleration;Address;adult stem cell;Affect;Age;Aging;angiogenesis;Biochemical;Biological;Blood capillaries;Blood Vessels;Cardiac;Cell Adhesion Molecules;Cell Communication;Cell Therapy;cell type;Cells;CX3CL1 gene;Data;density;design;Development;Direct Lytic Factors;Effectiveness;Elderly;Engineering;Engraftment;Exhibits;Experimental Animal Model;extracellular vesicles;functional decline;Functional disorder;Genetic Materials;HDAC4 gene;Health;Hip region structure;Histone Deacetylase Inhibitor;Homeostasis;Homing;human induced pluripotent stem cells;Immune response;In Vitro;induced pluripotent stem cell;Inflammation;Inflammatory;injured;Injury;innovation;interdisciplinary approach;Lentivirus Vector;Life;Lipids;Mediating;Messenger RNA;MicroRNAs;migration;Molecular;Molecular Biology;Mus;Muscle;muscle aging;Muscle Cells;Muscle Fibers;muscle form;Muscle function;muscle progenitor cell;muscle regeneration;muscle repair;Muscle satellite cell;muscle strength;Natural regeneration;novel;novel strategies;old mice;overexpression;paracrine;Parents;Personal Satisfaction;pharmacologic;Physiology;Population;Process;progenitor;Proliferating;Property;Proteins;Proteomics;Quality of life;regeneration potential;regenerative;Regenerative Medicine;Rejuvenation;repaired;Research;Role;Safety;sarcopenia;self-renewal;senescence;Signal Pathway;Signaling Molecule;Site;Skeletal Muscle;skeletal muscle wasting;small molecule;Somatic Cell;Source;stem;stem cell based approach;stem cell expansion;stem cells;Techniques;Testing;Time;Treatment Efficacy;tumor;Tumor Promotion;Vascular Cell Adhesion Molecule-1;Viral Vector

PROJECT_TITLE: hiPS cells derived skeletal muscle progenitors and their extracellular vesicles for treatment of sarcopenia

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Despite four globally approved vaccines, rotavirus remains a significant pathogen of severe diarrhea in children under five, accounting for nearly 130,000 deaths annually. We will use cutting-edge methods to understand how structures of viral components control virus replication and assembly of infectious particles. We expect our studies will provide a roadmap for gaining mechanistic insight into replication and maturation pathways in other viruses and help develop new antiviral strategies to counter rotavirus infection.

PI_NAMEs: PRASAD, BIDADI VENKATARAM (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Accounting;Affinity;Architecture;BCAR3 gene;Binding;Biochemical Reaction;Biological Assay;Biology;Biophysics;burden of illness;Calcium Channel;Capsid;Capsid Proteins;Cell-Matrix Junction;Cells;Cessation of life;Child;Client;Code;Complex;Core Assembly;Cryoelectron Microscopy;Crystallography;Cytoplasm;Development;Diarrhea;Disease;Double-Stranded RNA;Electron Microscopy;Endosomes;Enterotoxins;Enzymes;Event;experimental study;fascinate;Gastroenteritis;Gene Silencing;Genetic Transcription;Glycoproteins;glycosylation;Grant;Image;image processing;In Situ;In Vitro;infancy;Infection;insight;Length;Light;Liposomes;Liquid substance;Mediating;Membrane;Messenger RNA;Methods;Molecular;Molecular Conformation;Morphogenesis;mRNA capping;N-terminal;new technology;Nonstructural Protein;novel;particle;pathogen;Pathogenesis;Pathway interactions;Phase;Play;Polysaccharides;Process;Protein Biosynthesis;Proteins;reconstruction;Research;Resolution;reverse genetics;RNA;RNA Binding;RNA-Binding Proteins;Role;Rotavirus;Rotavirus Infections;Scaffolding Protein;structural determinants;Structure;System;Tail;Techniques;trafficking;Transcript;Translations;Vaccines;Vesicle;Viral;Viral Proteins;Virus;Virus Assembly;Virus Replication

PROJECT_TITLE: STRUCTURAL STUDIES ON ROTAVIRUS

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


NIH_SPENDING_CATS: Immunotherapy

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed research is will discover how our bodies come to know the difference between our own cells (our ‘Self’) and foreign organisms and genes. The project will allow us to better teach the immune system which things to attack and which to leave alone, thus enhancing health, lengthening life and reducing illness.

PI_NAMEs: KRUMMEL, MATTHEW F (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: analytical method;Antigen Presentation;Antigen-Presenting Cells;Antigens;Area;Autoimmunity;Biological Models;Biological Process;Biology;Cell Death;Cells;Competence;Complement;CRISPR screen;Cytometry;Cytosol;Data;Dendritic Cells;design;Diagnostic;draining lymph node;Educational process of instructing;Electron Microscopy;Engineering;exhaustion;Flow Cytometry;Generations;Genes;Genetic Screening;genetic testing;Goals;Grant;Health;high dimensionality;Homeostasis;human disease;Image;Immune;Immune system;Immunoassay;Immunologics;Immunotherapeutic agent;improved;In Vitro;in vivo;Infection;Ingestion;Injury;innovation;Intention;interest;Knock-out;Knowledge;Lead;Licensing;Life;Light;lymph nodes;Macrophage;Malignant Neoplasms;Mass Spectrum Analysis;Membrane;Memory;Methods;Microscopy;migration;Molecular;mutant;Myelogenous;Myeloid Cells;National Institute of Allergy and Infectious Disease;next generation;novel;Organelles;Organism;Phagocytosis;Population;Process;programs;Proteins;Proteomics;Reagent;Research;Research Personnel;Rest;Sampling;Self Perception;Self Tolerance;Specific qualifier value;Speed;Surface;Synapses;Systems Biology;T cell differentiation;T-Lymphocyte;Technology;Testing;Time;tumor;Tumor Antigens;Tumor Immunity;Tumor-associated macrophages;Vesicle;Work

PROJECT_TITLE: THE IMMUNE SELF-ASSOCIATED STORAGE ORGANELLE (SASO)

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project narrative The proposed research is relevant to public health because the discovery of molecular and circuit mechanisms of neurodegeneration is ultimately expected to increase understanding of Alzheimer’s disease pathogenesis. Results from this project are expected to help establish new frameworks for preventing disease progression and preserving brain network function in Alzheimer’s disease, and to contribute to the NIH’s goal to combat Alzheimer’s disease.

PI_NAMEs: IGARASHI, KEI M (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Acceleration;Affect;Affinity Chromatography;Age;Alzheimer's Disease;Alzheimer's disease patient;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Animal Disease Models;Animal Model;Animals;Atrophic;Axon;Back;Behavior;Brain;Brain region;calbindin;Caregivers;CASP3 gene;Cause of Death;Cell Death;Cell Physiology;cell type;Cells;combat;cost;Data;Dementia;design;Deterioration;Disease Progression;Electrophysiology (science);entorhinal cortex;Exhibits;Family;functional group;Future;Genes;Genetic;Goals;Hippocampus;Histologic;histological studies;Homologous Gene;imaging study;Immunohistochemistry;Impairment;improved;in vivo;Investigation;Knock-in;Knock-in Mouse;Knowledge;Lead;Literature;Medial;Memory;Memory impairment;Memory Loss;mental function;Methods;Mind;Molecular;mouse model;multidisciplinary;Mus;Nerve Degeneration;Neurons;novel;optogenetics;Pathogenesis;Patients;Pattern;Performance;Persons;Phase;preservation;prevent;Property;Public Health;Pyramidal Cells;Research;response;Retrieval;Ribosomes;Role;Site;Societies;spatial memory;stellate cell;Testing;Therapeutic;therapeutic target;transcriptome sequencing;Translating;United States National Institutes of Health;Viral;Wolfram Syndrome

PROJECT_TITLE: Cell-type-specific vulnerability of the entorhinal cortex in Alzheimer's disease


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Services;Patient Safety;Primary Health Care;Screening and Brief Intervention for Substance Misuse;Substance Misuse;Telehealth

ORG_CITY: EAST ROCHESTER

ORG_NAME: CHESS MOBILE HEALTH, INC.

PHR: Narrative Screening, Brief Intervention, and Referral to Treatment (SBIRT) is used by primary care providers and emergency departments to identify patients who are at risk for substance abuse or who require treatment for substance abuse. SBIRT identifies over 10 million patients per year in need of referral to treatment or behavioral modification. However, only about 15-20% of patients follow through with these recommendations. This is a proposal to develop a smartphone based app that is designed to increase adherence to recommendations for referral to treatment and behavioral modification in non-adherent patients.

PI_NAMEs: GRAVES, LISA ELLEN;MOREFIELD, HANS  (contact)

PROGRAM_OFFICER_NAME: FLOOD, MORRIS

PROJECT_TERMS: Accident and Emergency department;Address;Adherence;Alcohol abuse;Behavior Therapy;Caring;Cellular Phone;Clinical;Communication;Computers;Data;design;Destinations;digital technology;digital tool;Disease;Drug usage;efficacy study;efficacy testing;efficacy validation;Elements;feasibility testing;follow-up;Funding;Goals;Health;health information technology;Health Personnel;improved;Individual;innovation;Intervention;Knowledge;medical specialties;Mind;Modification;Monitor;National Institute of Drug Abuse;Notification;Outcome;outreach;Participant;Patient Care;Patient Compliance;patient engagement;Patient Noncompliance;Patients;personalized intervention;Pharmaceutical Preparations;Phase;primary care patient;primary care practice;primary care provider;primary care setting;programs;prototype;Provider;Randomized;randomized, clinical trials;Recommendation;Recovery;reduced substance use;Research;response;Risk;satisfaction;Screening procedure;Screening Result;screening, brief intervention, referral, and treatment;Secure;Self Management;Small Business Innovation Research Grant;smartphone application;Substance abuse problem;substance abuse treatment;substance use;Substance Use Disorder;success;tool;trend;usability;Validation;willingness;Work

PROJECT_TITLE: An innovative platform and smartphone app to deliver tailored interventions and facilitate completed referrals related to substance use.