NIH_SPENDING_CATS: Cancer;Immunotherapy;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative The proposed project will uncover new approaches to enhance the anti-cancer activity of immune cells, especially in the setting of aggressive malignancies that are refractory to current immune-based treatments. Upon completion, our project will provide new mechanistic understanding of how “stress signals” generated and delivered by tumors inhibit the protective function of our immune system. This knowledge should pave the way for developing novel forms of immunotherapy that more effectively control cancer progression and recurrence.

PI_NAMEs: CUBILLOS-RUIZ, JUAN R (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: anti-cancer;anti-tumor immune response;anticancer activity;arm;Ascites;ATF6 gene;Bioenergetics;biological adaptation to stress;Biological Assay;cancer cell;Cancer Control;cancer immunotherapy;cancer infiltrating T cells;Cancer Patient;cancer recurrence;carcinogenesis;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Cellular immunotherapy;Cellular Metabolic Process;chimeric antigen receptor T cells;Chromatin;Cleavage Under Targets and Release Using Nuclease;Cytoskeletal Proteins;Cytoskeleton;cytotoxic;Defect;Development;Disabling;Effectiveness;effector T cell;Elements;Endocrine;Endoplasmic Reticulum;endoplasmic reticulum stress;Epithelium;Event;Exhibits;Exposure to;fatty acid oxidation;fatty acid-binding proteins;Follicle Stimulating Hormone Receptor;Generations;Goals;Homeostasis;Human;Immune;immune cell infiltrate;Immune Evasion;Immune system;immunoregulation;Immunosuppression;Immunotherapy;improved;inhibitor;Intervention;Knowledge;Lipids;Luciferases;Maintenance;Malignant - descriptor;Malignant neoplasm of ovary;Malignant Neoplasms;Maps;Memory;Metabolic;metabolic fitness;misfolded protein;Mitochondria;Modification;Molecular;novel;novel strategies;Organelles;ovarian neoplasm;overexpression;Pathologic;Pathway interactions;pharmacologic;preservation;Process;Program Sustainability;programs;Protein Biosynthesis;protein folding;Refractory;Replacement Therapy;Reporter;Repression;Research;Respiration;Role;Safety;sensor;Signal Transduction;Site;SM 22 muscle protein;Solid;Solid Neoplasm;Stress;T cell infiltration;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;Tissues;trafficking;Transcription Repressor;Transgenic Mice;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor-infiltrating immune cells;uptake;XBP1 gene

PROJECT_TITLE: Immunometabolic Programs Controlled by ER Stress in Cancer

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Networking and Information Technology R&D (NITRD)

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHYSIOLOGY

ORG_FIPS: US

ORG_STATE: NY

PHR: Project Narrative The Tri-Institutional Training Program in Computational Biology and Medicine (CBM) is a collaborative PhD training program involving Cornell University in Ithaca, NY, the Weill Cornell Medical College in New York City, and the research programs of Memorial Sloan Kettering Cancer Center in New York City. The Program trains computational biologists in the approaches they need to solve complex interdisciplinary problems in biology and medicine and prepares them for research-related academic and non-academic computational biology careers following timely completion of their PhD degrees.

PI_NAMEs: KHURANA, EKTA ;LESLIE, CHRISTINA S (contact);YU, HAIYUAN

PROGRAM_OFFICER_NAME: DAVANI, BEHROUS

PROJECT_TERMS: Computational Biology;Doctor of Philosophy;Institution;Medicine;programs

PROJECT_TITLE: Tri-Institutional PhD Program in Computational Biology and Medicine

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: ITHACA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE  The seminal fluid proteins (Sfps) that accompany sperm into the female are important contributors to male fertility and are also molecular agents of sexual conflict. This proposal takes a combined functional and evolutionary approach to determine how Sfps work with the female and with sperm for optimal fertility, and to use them to probe sexual conflict molecularly. By exploiting the experimental advantages of the Drosophila model system to examine how Sfps function and evolve, we will obtain information that will be useful to diagnose certain forms of infertility, to design ways to control the mosquitoes that transmit serious human diseases and, potentially, to optimize conditions for assisted reproductive technologies.

PI_NAMEs: WOLFNER, MARIANA FEDERICA (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Affect;Animals;Area;Assisted Reproductive Technology;Behavior;Binding;Binding Proteins;Biochemical;Biochemistry;Biological Assay;Biological Models;Biology;candidate identification;Cell Culture Techniques;Conflict (Psychology);CRISPR/Cas technology;Cysteine;Data;Dengue;design;Diagnosis;Directed Molecular Evolution;Disease;Drosophila genus;Drosophila inturned protein;Evolution;experimental study;Female;female reproductive tract;Fertility;Funding;Future;Gene Expression;Genetic;Genetic Models;Genetic Screening;genetic signature;Genome;Gland;Grant;Health;Human;human disease;improved;In Vitro;Individual;Induced Neurons;Infertility;Insect Control;insect disease vector;Insecta;interest;Invertebrates;Investigation;Lectin;Ligands;Location;Malaria;male;male fertility;Male Infertility;Mammalian Oviducts;Mammals;Mass Spectrum Analysis;Measures;Mediating;Methods;microCT;Modeling;Molecular;Molecular Conformation;Molecular Genetics;Mosquito Control;Mus;Muscle Contraction;Mutation;Nature;neuromuscular;Neurons;offspring;Organism;Orthologous Gene;Ovulation;Ovulation Induction;Partner in relationship;Pathway interactions;Peptide Hydrolases;Peptides;phenomenological models;Phenotype;Physiological;Physiology;Play;Prostate;protein function;Proteins;Proteome;Proteomics;receptor;Relaxation;Reproduction;reproductive;Reproductive Physiology;reproductive success;reproductive tract;Resources;response;Role;secretory protein;Seminal;Seminal fluid;Seminal Plasma;Seminal Vesicles;sex;Signal Transduction;Site;sperm cell;sperm function;sperm protein;Sterility;System;Testing;tool;transmission process;Variant;Work;X-Ray Computed Tomography;ZIKA

PROJECT_TITLE: Actions of Seminal Proteins in Mated Drosophila Females

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Nutrition

ORG_CITY: INDIANAPOLIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE The mechanisms behind impaired skeletal health with advancing age are still unclear, however defective energy metabolism is known to be associated with aging in multiple tissues. This proposal will investigate the role of energy metabolism in osteocytes, key regulatory bone cells, in response to mechanical loading and during aging. This work will enable us to identify novel strategies to maintain bone health during aging by targeting osteocyte energy metabolism.

PI_NAMEs: KITASE, YUKIKO  (contact);PRIDEAUX, MATTHEW

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Affect;Age;age effect;age related;Age-Related Bone Loss;aged;Aging;antagonist;Attenuated;Biology;bone;bone aging;bone cell;bone health;bone loss;bone mass;Bone Resorption;Carnitine Palmitoyltransferase I;Cell Respiration;Cells;Data;Economic Burden;Elderly;Energy Metabolism;Fatty Acids;Female;fluid flow;Fracture;frailty;Future;Goals;Health;Hip Fractures;Homeostasis;Impairment;improved;In Vitro;in vivo;Investigation;juvenile animal;Knowledge;lifestyle intervention;Lipids;Maintenance;mechanical load;Mechanical Stimulation;Mechanics;men;Metabolic;Metabolic Pathway;Metabolism;Methods;Molecular;Morbidity - disease rate;mortality;Mus;Musculoskeletal;Musculoskeletal Diseases;novel;novel strategies;old mice;Osteoblasts;Osteoclasts;Osteocytes;Osteogenesis;oxidation;Oxidative Phosphorylation;Pathologic;Pathology;Pathway interactions;Patients;pharmacologic;Play;PPAR delta;prevent;Process;Production;promoter;Regulation;response;Risk;Role;shear stress;Signal Transduction;skeletal;Skeletal system;Skeleton;Source;Testing;therapeutic target;Tissues;Woman;Work

PROJECT_TITLE: Osteocyte energy metabolism in aging

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: GALVESTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Emerging and re-emerging infectious agents have caused large outbreaks in recent years. In this T32 Training program we will train physician-scientists to be equipped to respond to emerging infectious diseases through instruction in research design and methods; biostatistics; outbreak investigation; clinical and research biocontainment and biosafety; field epidemiology; and scientific writing. Trainees will apply their training in the conduct of translational research while receiving intensive scientific and career mentorship through a novel Team Science framework.

PI_NAMEs: MELBY, PETER C. (contact);PAESSLER, SLOBODAN

PROGRAM_OFFICER_NAME: BROWN, LILIANA L

PROJECT_TITLE: Physician-Scientist Training in Emerging Infectious Diseases

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: ROCHESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative MicroRNAs are essential regulators of gene expression, alterations in which have been shown to disrupt entire cellu- lar pathways, substantially contributing to a variety of human diseases. Statistical methods that explicitly address the challenges inherent in measuring microRNA expression are necessary to fully elucidate the role microRNAs play in many human disease processes.

PI_NAMEs: MCCALL, MATTHEW NICHOLSON (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Address;Base Sequence;Binding;Bioconductor;Biological;Biological Assay;Case Study;Cations;Communities;Complex;Computer software;Data;data modeling;Dependence;design;Development;experimental study;Gene Expression;Genetic Transcription;Goals;human disease;improved;insight;lectures;Length;Libraries;Maps;Measures;Messenger RNA;Methodology;Methods;MicroRNAs;Modeling;mRNA sequencing;novel;Nucleotides;open source;Pathway interactions;Play;Preparation;Probability;Process;Protein Isoforms;Regulator Genes;Research;RNA;RNA-Induced Silencing Complex;Role;Sampling;Small RNA;Statistical Data Interpretation;Statistical Methods;The Cancer Genome Atlas;tool;Transcript;transcriptome sequencing;Translations;Uncertainty;Variant;Work

PROJECT_TITLE: Statistical Methods for MicroRNA-Seq Experiments

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Racial and Ethnic Minority Health Research;Regenerative Medicine;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Embryonic - Human;Transplantation

ORG_CITY: IRVINE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE  Exposure to social disadvantage represents the most salient determinant of population health disparities in our nation. Our goal is to better understand the phenomenon of biological embedding of social disadvantage in the con- text of health and health disparities in obesity and metabolic outcomes. We hypothesize that the effects of social disadvantage may extend all the way down to the level of stem/progenitor cells – the cells that continually replenish our tissues and organ systems. In a study of Hispanic, non-Hispanic Black, and non-Hispanic White mother-child dyads, our project will test this hypothesis in stem cells obtained from child tissues (umbilical cord) at the time of birth. We will measure cellular features of child mesenchymal stem/progenitor cells (MSCs) and MSC-derived fat cells, along with newborn fat mass and glucose-insulin physiology. We expect our study findings to suggest avenues to better optimize long-term health and well-being.

PI_NAMEs: BOYLE, KRISTEN ELIZABETH;ENTRINGER, SONJA ;WADHWA, PATHIK D (contact)

PROGRAM_OFFICER_NAME: MARTIN, IMAN

PROJECT_TERMS: Activities of Daily Living;Address;Adipocytes;Adipose tissue;Animals;Back;Basic Science;Behavioral;beta catenin;biobank;Biological;Biological Phenomena;Biology;Birth;Black race;Body Composition;Body System;burden of illness;Cell Culture System;Cell Culture Techniques;Cell Differentiation process;Cell Line;Cell Physiology;cell type;Cells;Cellular biology;cellular targeting;Characteristics;Child;Clinical Investigator;clinical phenotype;clinically relevant;clinically significant;cohort;Collaborations;Communities;Cord Blood stem cells;Coupled;Data;Densitometry;Development;differentiation in vitro;disorder risk;Disparity;Early Diagnosis;Embryo;Endocrine;Ensure;Epigenetic Process;Ethnic Origin;experimental study;Exposure to;Fatty acid glycerol esters;fetal;Functional disorder;Future;Gene Expression Profile;Generations;Glucose;Goals;Health;health disparity;health disparity populations;Hispanic;Homeostasis;Human;human stem cells;Immune;imprint;in utero;In Vitro;in vivo;Individual;Inflammatory;innovation;Insulin;insulin regulation;insulin sensitivity;interest;Investigation;Knowledge;Life;life span;Ligands;Long-Term Effects;Machine Learning;Maternal Exposure;Measures;Mediating;Mesenchymal;Mesenchymal Stem Cells;Metabolic;Metabolic dysfunction;metabolic phenotype;Methods;Mitochondria;Molecular;Mothers;Nature;Neonatal;newborn adiposity;Newborn Infant;Not Hispanic or Latino;novel;Obesity;offspring;Outcome;Participant;Pathway interactions;Personal Satisfaction;personalized intervention;personalized predictions;Phenotype;PhenX Toolkit;Physiology;Placenta;Population;PPAR gamma;predictive modeling;Pregnancy;Prevention;primary outcome;Process;progenitor;Proxy;psychosocial;Public Health;Publishing;Race;Recommendation;recruit;Research Design;Research Personnel;Resolution;Resource Sharing;Risk;sex;shared repository;social disparities;stem;stem cell biology;stem cell function;stem cell population;stem cells;stemness;Stress;Stromal Cells;Testing;Time;Tissue Sample;Tissues;translational approach;transmission process;Umbilical Cord Blood;Umbilical cord structure;United States National Institutes of Health;Variant;World Health Organization

PROJECT_TITLE: BIOLOGICAL EMBEDDING OF SOCIAL DISADVANTAGE IN HUMAN STEM CELLS: IMPLICATIONS FOR HEALTH DISPARITIES

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Relevance Statement The number of pediatric cancer survivors in the U.S is approaching 500,000. Because these survivors experience various complications and comorbidities related to their malignancy and treatment, there is a need for research to evaluate the influence of patient-specific demographic and genetic factors, premorbid and comorbid conditions, health behaviors, and aging on cancer treatment-related toxicity. The St. Jude Lifetime Cohort is providing new insights into the risks and underlying pathophysiology of adverse long-term effects, providing possible targets for intervention in this high-risk population.

PI_NAMEs: HUDSON, MELISSA M (contact);NESS, KIRSTEN KIMBERLIE

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: Acceleration;Address;Adolescent;Adult;adverse outcome;Age;Aging;Architecture;Auditory system;Award;biobank;Biological Markers;Biological Specimen Banks;Blood;cancer diagnosis;Cancer Patient;Cancer Survivorship;Cardiovascular system;Childhood;childhood cancer survivor;Childhood Cancer Treatment;Clinical;clinical application;Clinical assessments;Clinical Data;clinical predictive model;cloud based;Cloud Computing;cohort;Collaborations;Communities;comorbidity;Complex;Data;Data Analytics;data infrastructure;data registry;Data Set;data sharing;Data Sources;Databases;demographics;design;Development;Diagnosis;Eligibility Determination;Endocrine system;Enrollment;Environment;Evaluation;exome;exome sequencing;experience;field study;flexibility;follow-up;Functional disorder;Funding;Future;Genetic;genome sequencing;genomic data;Genomics;Germ Lines;Grant;handheld mobile device;health assessment;Health behavior;health related quality of life;high risk;high risk population;human old age (65+);Individual;Informed Consent;Infrastructure;innovation;insight;Institution;interest;interoperability;Intervention;Intuition;Investigation;Late Effects;life span;Long-Term Effects;Long-Term Survivors;Malignant Childhood Neoplasm;Malignant Neoplasms;Manuscripts;Measures;Medial;Medical;mHealth;Monitor;Morbidity - disease rate;Neoplasms;Neurocognitive Deficit;next generation sequence data;next generation sequencing;Outcome;Participant;participant enrollment;Patient Self-Report;Patients;Pediatric cohort;Peer Review;Performance;Phenotype;Physiological;Population;predictive modeling;predictive tools;Preventive;Productivity;prospective;Public Health;Publishing;repository;Reproductive system;Research;research clinical testing;Research Personnel;Resources;Respiratory System;Risk;Risk Estimate;risk prediction;risk prediction model;Role;Saint Jude Children's Research Hospital;Sampling;Secure;sensor;Services;shared database;sharing platform;sociodemographics;Source;success;Survivors;survivorship;Testing;therapy adverse effect;Time;Treatment Protocols;Treatment-Related Cancer;Treatment-related toxicity;Urine;Validation;Vial device;Visit;Visualization;Visualization software;whole genome

PROJECT_TITLE: The St. Jude Lifetime Cohort


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Dysregulation of glutamate transporter subtype 1 (GLT-1) contributes to cocaine and opioid dependence and relapse. GLT-1 activators display efficacy in animal models of cocaine and opioid addiction, but they are limited primarily to β-lactam antibiotics that are not well tolerated by patients. By providing the first comprehensive in vivo study of GLT-1 activators that are structurally and mechanistically distinct from β-lactam antibiotics, we expect to provide an initial step in identifying non-β-lactam GLT-1 activators as potential treatments for drug addiction and related CNS diseases.

PI_NAMEs: RAWLS, SCOTT M. (contact);REITZ, ALLEN B

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: abuse liability;Active Biological Transport;addiction;Address;Adverse effects;Affect;Agonist;analog;Animal Model;Antibiotic Resistance;aqueous;Astrocytes;Behavioral;beta-Lactams;Biological Assay;Biological Markers;Brain;Brain Ischemia;Buprenorphine;Central Nervous System Diseases;Cerebellar Ataxia;Chemistry;Chronic;Clinic;clinical translation;Clinical Trials;Cocaine;Cocaine Abuse;Cocaine Dependence;cocaine exposure;cocaine relapse;conditioned place preference;Cues;Data;Dependence;design;Development;Diarrhea;Dose;Drug abuse;Drug Addiction;Drug Kinetics;drug relapse;drug-like compound;druggable target;effective therapy;effectiveness testing;Enhancers;Enzymes;extracellular;Female;Food;gastrointestinal system;Generations;GLAST Protein;Glutamate Transporter;Glutamates;healthy volunteer;improved;In Vitro;in vivo;in vivo evaluation;Intake;interest;Intestinal Absorption;Investigation;Laboratories;Lactams;Link;Liver;liver metabolism;Locomotion;male;Metabolic;Metabolism;Methadone;Modeling;Morphine;Motor Activity;Naloxone;Nervous System Disorder;neurochemistry;Neurological Models;Neurons;Nucleus Accumbens;Obsessive-Compulsive Disorder;Opiate Addiction;Opioid;opioid exposure;Oral;Outcome;Oxycodone;painful neuropathy;parenteral administration;Parents;Patients;Peptides;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Pharmacology;Pharmacotherapy;Phase I Clinical Trials;Physical Dependence;Plasma;pre-clinical;Pre-Clinical Model;preclinical study;preference;Prodrugs;protein expression;Proteins;Psychological reinforcement;Rattus;Relapse;Replacement Therapy;reuptake;Rewards;Riluzole;Safety;Schedule;Self Administration;Solubility;Spinal;Sucrose;System;Testing;therapeutic target;Translations;transmission process;Up-Regulation;uptake;Withdrawal

PROJECT_TITLE: Non-beta-lactam GLT-1 activators: characterization in preclinical models of opioid and cocaine addiction

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Malaria remains one of the leading causes of death in children under five years of age in Sub-Saharan Africa, with the majority of these deaths attributable to Plasmodium falciparum infection. The recent global stall in the reduction of malaria deaths has made the development of an effective vaccine essential; however, a major challenge to developing an efficacious vaccine is the extensive diversity of Plasmodium falciparum antigens. Using the wealth of genomic resources currently available, together with targeted Plasmodium genome editing, we will fill a critical need in the malaria vaccine development field by bringing genetic diversity in candidate antigens to the forefront of vaccine candidate credentialing ultimately creating a systematic framework for evaluating new vaccine candidate antigens and combinations that will provide broadly neutralizing antibodies for inclusion in a globally effective vaccine.

PI_NAMEs: BEI, AMY KRISTINE (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: 5 year old;Acceleration;Africa;Africa South of the Sahara;Alleles;Antibodies;Antigenic Diversity;Antigens;attributable mortality;Binding;Biochemical;Biological Assay;Blood;candidate validation;Cause of Death;CD147 antigen;Cessation of life;Child;clinical development;cohesion;Complex;cost;Country;Credentialing;CRISPR/Cas technology;Development;Disease;Drug resistance;Epitopes;Evaluation;Evolution;fitness;Genetic;Genetic Polymorphism;Genetic Variation;Genome;genome editing;genome resource;Genomic approach;genomic data;Genomics;Goals;Growth;Human;human monoclonal antibodies;Immune;Immune Evasion;Immune response;Immune system;Immunity;Immunoglobulins;In Vitro;Individual;Infection;insight;Institution;Invaded;Kinetics;Knowledge;Longitudinal cohort;Malaria;Malaria Vaccines;Measures;member;Methods;neutralizing antibody;neutrophil;next generation;next generation sequencing;novel;novel strategies;novel vaccines;Organism;Parasite resistance;Parasites;Patients;Pharmaceutical Preparations;Phase;Phase II Clinical Trials;phase II trial;phase III trial;Phenotype;Plasmodium;Plasmodium falciparum;Plasmodium genome;Play;Population;Positioning Attribute;Pregnant Women;Process;protective efficacy;protein complex;Public Health;Publishing;receptor;receptor binding;Recombinant Proteins;Research;Respiratory Burst;Role;Scientist;Specificity;Standardization;structural biology;Structure;Surface Plasmon Resonance;Technology;Testing;tool;Transgenic Organisms;transmission process;Tropical Disease;vaccine candidate;Vaccine Design;vaccine development;vaccine discovery;vaccine efficacy;vaccine formulation;vaccine trial;vaccine-induced immunity;Vaccines;vaccinology;Variant;Virus Diseases;volunteer

PROJECT_TITLE: Evaluating the Functional Impact of Genetic Diversity on Malaria Vaccine Candidates


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Screening and Brief Intervention for Substance Misuse;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: TALLAHASSEE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: This study begins to address a critical need for interventions that reduce both problem substance use (PSU) and HIV risk behavior among MSM in Latin America by adapting two evidence-based interventions, e-SBI and YMHP, for MSM in Argentina seeking HIV testing. Given that many MSM seek HIV testing in LGBT community agencies, these interventions have the potential to reach large numbers of MSM, help them reflect on their use of drugs and alcohol, and help link those with PSU to care. If proven efficacious in a future RCT, the implementation of these intervention in such agencies will help address a key contributor to HIV risk behavior and infection as well as reduce drug and alcohol use among MSM, who are disproportionately affected by HIV and substance use.

PI_NAMEs: BALAN, IVAN C (contact)

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: acceptability and feasibility;Acute;Address;Affect;aged;AIDS prevention;Alcohol consumption;Alcohols;Argentina;brief intervention;Caring;Client;Cocaine;Collaborations;Communities;community partners;condomless anal sex;Dependence;Development;Drug usage;Early Intervention;effective intervention;Effectiveness;efficacy trial;Electronics;Europe;evidence base;Evidence based intervention;Feeling;Funding;Future;Gays;General Population;Health;Heavy Drinking;high risk;HIV;HIV Infections;HIV risk;Human immunodeficiency virus test;illicit drug use;implementation barriers;implementation intervention;Incidence;Individual;Infection;Infrastructure;Intervention;Latin America;Lesbian Gay Bisexual Transgender;Link;male health;marijuana user;Measures;men;men who have sex with men;Mental Health;Motivation;motivational enhancement therapy;Outcome;Participant;Persons;pilot trial;Population;Postpartum Women;Prevalence;preventive intervention;Process;Professional counselor;programs;prospective;Randomized;recruit;reduced substance use;Reporting;Research Infrastructure;Resources;retention rate;Risk;Risk Behaviors;Risk Reduction;screening;screening guidelines;screening, brief intervention, referral, and treatment;Services;sexual risk behavior;sexual risk reduction;Substance abuse problem;substance abuse treatment;Substance Addiction;substance use;Substance Use Disorder;Sulfate;Tablets;Testing;Time;Training;Tranquilizing Agents;United States National Institutes of Health;United States Substance Abuse and Mental Health Services Administration;uptake;young man;young men who have sex with men

PROJECT_TITLE: Integration of Electronic SBI(RT) into an HIV Testing Program to Reduce Substance Use and HIV risk Behavior among MSM in Argentina

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Natural Products

ORG_CITY: BOSTON

ORG_DEPT: CHEMISTRY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: Alkaloid biosynthetic studies NARRATIVE  Alkaloid biosyntheses are known to be a gold mine for novel/unprecedented transformations. In this proposal, besides in-depth mechanistic characterization of the novel, unprecedented transformations (e.g., endoperoxidation and oxidative C-S bond formation), we will also apply these mechanistic information to guide our genome-mining efforts.  Many of the compounds containing the functional groups (endoperoxide, epoxide, and thiols) have biological activities (e.g., anti-cancer, anti-infective, or having beneficial effects on many ageing associated diseases).

PI_NAMEs: LIU, PINGHUA  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Acids;Active Sites;Aerobic;Affect;aging related disease;Alkaloids;alpha ketoglutarate;Anabolism;analytical method;anti-cancer;Anti-Infective Agents;base;Binding;Binding Sites;Biochemical;Biological;Catalysis;chemical synthesis;Chemistry;chlorination;Comparative Study;Complex;computer studies;computerized tools;Cysteine;cysteine sulfinic acid;Data;dehydrogenation;Development;Distal;Enzymatic Biochemistry;Enzyme Activation;enzyme activity;Enzymes;epimerization;Epoxy Compounds;frontier;functional group;Genome;Goals;Gold;Growth;Histidine;Human;Hydrogen Bonding;Hydroxylation;Iron;Kinetics;life span;Literature;Mass Spectrum Analysis;Methods;Mining;Modeling;Mononuclear;mouse model;mutant;Mutation;Natural Products;Nature;novel;Oxidants;oxidation;Oxidation-Reduction;Oxygen;Pathway interactions;people of color;Play;programs;Reaction;Refsum Disease;Reporting;Site;Structure;Sulfhydryl Compounds;System;Tyrosine;unnatural amino acids;Work

PROJECT_TITLE: Alkaloid Biosynthetic Studies


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Substance Misuse;Substance Misuse Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE I propose to determine whether the intermittent restriction and subsequent reintroduction of benzodiazepine coverage reduced the incidence of benzodiazepine-related harms among patients with indications for benzodiazepines use. A comprehensive evaluation of these restriction policies in a non-institutionalized population will inform the ongoing development of strategies to reduce the risk of benzodiazepine-related harms, including overdose and death.

PI_NAMEs: WIESE, ANDREW DAVID (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: addiction;Adult;barrier to care;Benzodiazepines;Cessation of life;Clinical;Country;Data;Data Sources;design;Development;Drug Prescriptions;Drug usage;dual eligible;Dual Enrollment;Epilepsy;Evaluation;Excision;Exclusion;falls;Fracture;Future;Health;High Prevalence;high risk;Hospitalization;Impact evaluation;Incidence;Institutionalization;Insurance;Intervention;Link;Longitudinal cohort;Malignant Neoplasms;Medicaid;Medicaid eligibility;Medicare;medication safety;Medicine;Mental disorders;Mental Health;Mentors;Methodology;Methods;National Institute of Drug Abuse;Natural experiment;Neurodegenerative Disorders;Opioid;opioid epidemic;opioid overdose;opioid use;opioid use disorder;Outcome;Outpatients;Overdose;overdose prevention;Patients;Personal Satisfaction;Pharmaceutical Preparations;Pharmacoepidemiology;Policies;Policy Analysis;Population;Population Control;Privatization;programs;Psychotropic Drugs;Public Health;Recommendation;Records;Registries;Research;Risk Reduction;Safety;secondary analysis;Seizures;Sleeplessness;Spasm;Strategic Planning;Subgroup;System;Tennessee;Testing;Time;Training;training opportunity;Work

PROJECT_TITLE: Benzodiazepine restrictions and the prevention of overdoses and other harms

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Estrogen;Genetics;Rare Diseases;Scleroderma;Women's Health Research

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Systemic sclerosis (SSc) is a disease with no known cause or cure. We reported that concordance for SSc in twins is lower than that reported for other rheumatic diseases. We propose to conduct a follow-up study of concordance in the twin cohort, and to identify associations of elevated estrogen levels in the SSc phenotype. Through this award, the PI will continue to mentor junior clinician investigators to ensure a pipeline of future independent investigators with clinical research interests focused on Scleroderma.

PI_NAMEs: FEGHALI-BOSTWICK, CAROL A. (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Affect;African American population;African American Women;Age;Aromatase Inhibitors;Autoantibodies;Autoimmune Diseases;Award;career;career development;Caucasians;Cells;Characteristics;Clinical;clinical center;Clinical Investigator;Clinical Research;Clinical Trials;cohort;Cohort Studies;collaborative environment;Collection;Connective Tissue Diseases;Coupled;Cross-Sectional Studies;Cutaneous;Data;Data Analyses;Dermal;design;Detection;Development;Diffuse;Disease;disease phenotype;Dizygotic Twins;DNA Methylation;efficacy testing;Ensure;Entrepreneurship;Environment;Epigenetic Process;epigenetic profiling;epigenetic regulation;Estradiol;Estrogens;Etiology;Evaluation;Exposure to;Fibroblasts;Fibrosis;follow-up;Follow-Up Studies;Foundations;Future;Gene Expression;Gene Expression Profiling;Genetic;Goals;Human;Individual;industry partner;Informed Consent;Inherited;innovation;Institution;interest;Junior Physician;Lead;Licensing;Macrophage;Manuscripts;Measurement;Measures;Mediating;Medical;meetings;men;Mentors;Methylation;Mission;monocyte;Monozygotic twins;Morbidity - disease rate;mortality;Nucleic Acid Regulatory Sequences;Participant;Pathogenesis;Pathway interactions;patient oriented;patient oriented research;Patient Recruitments;Patients;Peptides;Persons;Phase;phase I trial;Phenotype;Physicians;Postmenopause;Predisposition;Preparation;programs;Publishing;Raynaud Disease;Reporting;Research;Research Personnel;Resources;responsible research conduct;Rheumatism;Rheumatology;Role;Sampling;Scientist;Scleroderma;Serology;Site;Skin;skin fibrosis;South Carolina;supportive environment;Systemic Scleroderma;Testing;Training;Translational Research;Twin Multiple Birth;Twin Studies;Universities;virtual;Woman;Writing

PROJECT_TITLE: Scleroderma Twin Study and analysis of Estrogen in patients with dcSSc

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Physical Injury - Accidents and Adverse Effects;Primary Health Care;Rehabilitation;Social Determinants of Health;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

PHR: RELEVANCE TO PUBLIC HEALTH Older adults are at increased risk of sustaining a traumatic brain injury (TBI). Limited evidence exists on the patterns of care and services provided to older adults who transition home following acute or post-acute care hospitalization. Evaluating the provision of care and services following TBI is essential to identifying disparities in care and improving the quality of care for older adults with TBI.

PI_NAMEs: PAPPADIS, MONIQUE RENAE (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Acceleration;Accident and Emergency department;Accounting;Acute;acute care;Address;Administrator;advanced analytics;Age;aged;Area;barrier to care;behavioral health;Brain Injuries;care delivery;care outcomes;care providers;career;career development;Caregivers;Caring;Case Manager;Cessation of life;Characteristics;Chronic;Chronic Care;Chronic Disease;clinical care;cohort;Communities;comorbidity;Continuity of Patient Care;Data;Decision Making;Development;disability;Disease;disease model;Elderly;Epidemic;ethnic minority;Ethnic Origin;evidence base;Evidence based intervention;Exclusion;Foundations;Funding;Future;Geriatrics;Goals;Health;health care delivery;health care disparity;health care service utilization;health disparity;Health Personnel;Health Policy;Health Services;Home;Home Nursing Care;hospital readmission;Hospitalization;Hospitals;human old age (65+);implementation science;improved;Incidence;Individual;Injury;Institutionalization;Intervention;intervention mapping;Interview;life span;Long-Term Care;Long-Term Care Nursing;Managed Care;medical specialties;Medicare;Mentored Research Scientist Development Award;Mentors;Mentorship;Methodology;Methods;Modeling;neighborhood disadvantage;Nurses;Nursing Homes;Occupational;Occupational Therapy;older adult;Outcome;Outcome Study;Patients;Pattern;Patterns of Care;Persons;Physical therapy;Physicians;Play;primary care visit;Process;programs;Provider;Public Health;Quality of Care;Race;Recommendation;Research;Research Activity;Research Personnel;Risk;Role;satisfaction;Services;Severities;sex;skills;Social Workers;sociodemographics;socioeconomic disadvantage;Socioeconomic Status;Speech;Speech Therapy;stakeholder perspectives;Structure;Symptoms;therapy development;Time;Training;Training Activity;Translating;Traumatic Brain Injury;treatment as usual;United States National Institutes of Health;Visit

PROJECT_TITLE: Chronic Care Management of Geriatric Traumatic Brain Injury

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Depression;Machine Learning and Artificial Intelligence;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Physical Activity;Precision Medicine;Rehabilitation;Serious Mental Illness

ORG_CITY: AMES

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: PROJECT NARRATIVE Depression is a leading cause of disability worldwide and current treatments, such as psychotherapy and medication, are ineffective for many people, leading to a high global burden of depression. This project will investigate the efficacy of a 16-week Resistance Exercise Training (RET) program for treatment of Major Depressive Disorder via improving cerebrovascular mechanisms and using machine learning to inform future precision medicine approaches by modeling changes in depression outcomes, cerebrovascular function, and variation in adherence. If efficacy is confirmed, this highly translatable, accessible, low-cost treatment would add a novel behavioral treatment option for MDD while the machine learning modeling will independently help to improve treatment prescription and optimization for people with depression and other serious mental illnesses.

PI_NAMEs: MEYER, JACOB D (contact)

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: Acute;Adherence;Adult;anti-depressive agents;antidepressant effect;arm;base;Behavior Therapy;Behavioral;Behavioral Model;Blood;Blood Flow Velocity;cerebrovascular;Cerebrovascular Circulation;Cerebrum;Classification;Clinical;clinical predictors;confirmatory trial;Data;Depressed mood;depressive symptoms;Diagnosis;disability;Disease remission;Dose;DSM-V;Effectiveness;efficacious treatment;Exercise;exercise training;Foundations;Future;Goals;Health Care Costs;Human;improved;Individual;insight;Intervention;Intervention Studies;Investigational Therapies;Link;Machine Learning;machine learning model;Major Depressive Disorder;Measures;Mediating;Mediation;Mental Depression;Mental disorders;Meta-Analysis;Methods;middle cerebral artery;Modeling;Mood Disorders;novel;Outcome;Participant;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phase;Pilot Projects;Population;precision medicine;Precision Medicine Initiative;Prediction of Response to Therapy;Prevalence;Productivity;programs;Psychiatry;Psychotherapy;random forest;Randomized, Controlled Trials;Recording of previous events;reduce symptoms;Research;resistance exercise;response;Rest;Sampling;severe mental illness;social;Societies;Source;standard care;success;supervised learning;Testing;therapy development;tool;Training Programs;Translating;treatment adherence;treatment as usual;Treatment Cost;treatment optimization;treatment program;treatment response;Variant;Work

PROJECT_TITLE: Resistance Exercise to Treat Major Depression via Cerebrovascular Mechanisms: Confirming Efficacy and Informing Precision Medicine


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Infectious Diseases

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE  How the behaviors or experiences of one’s grandparents might affect our own health is not clear, but examples of the influence of transgenerational inheritance on metabolism, longevity, and even behavior have been documented in several model systems, and is surmised to exist in humans; furthermore, trans-kingdom signaling between bacteria and host cells might play a role in influencing behavior and transgenerational inheritance. We found that C. elegans can “read” the identity of bacteria through the bacteria’s own small RNAs, and subsequently use that information to influence behavior, avoiding the pathogen and passing this information on to four generations of progeny – and it may have co-opted a genomic “parasite,” a retrotransposon, to do so. We propose to use this system to identify the molecular regulators of the process, and to understand the logic of the system and its evolution.

PI_NAMEs: MURPHY, COLEEN TARA (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TITLE: Cracking the Code of Transgenerational Inheritance of Behavior


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Neurodegenerative;Neurosciences;Pediatric;Prevention;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: HUGO W. MOSER RES INST KENNEDY KRIEGER

ORG_STATE: MD

PHR: PROJECT NARRATIVE Cerebral Adrenoleukodystrophy (CALD) is a neurologically devastating, inflammatory demyelinating disease of childhood that leads to a vegetative state or death in months to years. Treatments are most effective when initiated in the narrow window prior to the onset of neurological symptoms, however early identification of CALD is a significant challenge. In this project, we will study the transition from normal brain development to cerebral demyelination using advanced imaging techniques in order to widen the treatment window, provide lead-time for possible preventative strategies, and thereby help maximize neurological outcomes.

PI_NAMEs: MALLACK, ERIC  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: 18 year old;Adolescent;Adrenoleukodystrophy;Adult;Affect;Age;Anisotropy;Appearance;Architecture;Autopsy;Biology;biomarker development;Biometry;boys;Brain;career development;Cerebrum;Cessation of life;Child;Childhood;clinical application;Consensus;Corpus Callosum;Data;Demyelinating Diseases;Demyelinations;Development;Diffusion;Disease;Disease Progression;Early Diagnosis;Early identification;Early Intervention;Encephalitis;extracellular;Fiber;Functional disorder;General Hospitals;Genes;Genetic;Goals;Growth;Hematopoietic Stem Cell Transplantation;Histologic;Histopathology;Image;Image Analysis;imaging biomarker;Imaging Techniques;in vivo;Incidence;Individual;infancy;Inflammatory;Injury;Institution;inter-institutional;Investigation;Lead;Lesion;leukodystrophy;Lipids;Literature;longitudinal analysis;Magnetic Resonance Imaging;Massachusetts;Measurement;Measures;medical schools;Mentors;Mentorship;Minority;Modality;Modeling;Monitor;Morbidity - disease rate;mortality;Multiple Sclerosis;Mutation;Myelin;Neonatal Screening;Nerve Degeneration;Nervous System Disorder;Neurocognitive Deficit;Neurodevelopmental Disorder;neurogenetics;neuroimaging;Neurologic;Neurologic Symptoms;Neurological outcome;Pathogenesis;Pathologic;Patient Care;Patients;pediatric patients;post-transplant;Prevention strategy;Procedures;Process;Publishing;Research Personnel;Site;skills;Structural defect;Techniques;Testing;Time;Training;Translating;validation studies;Vegetative States;Very Long Chain Fatty Acid;Water;white matter;White Matter Disease;Work

PROJECT_TITLE: Leveraging Myelin-Sensitive Imaging to Predict Early Lesion Pathogenesis in Cerebral Adrenoleukodystrophy

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ADMINISTERING_IC: DK

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Prevention

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative The goal is to improve the procedure of colonoscopy by improving a physician’s skill of probe insertion measured by the cecal intubation rate (CIR), improving a physician’s visualization thoroughness measured by colonoscopy adenoma detection rate (ADR), and reducing endoscope forces that can cause colon damage. This is achieved through the development of a Manikin Advanced Feedback Trainer (MAFT) that uses a sensorized manikin and offers guided optimization-based feedback to efficiently advance skills. The approach proposed adds broad knowledge about diverse colon anatomy geometries, optimal endoscope control strategies, and successful manikin sensorization training techniques.

PI_NAMEs: MILLER, SCARLETT ;MOORE, JASON ZACHARY (contact)

PROGRAM_OFFICER_NAME: ANDERSEN, DANA K

PROJECT_TERMS: 3-Dimensional;adenoma;Adult;aged;American;Anatomy;Benchmarking;Cancer Detection;Cecum;Characteristics;Colon;Colon Carcinoma;Colonoscopy;Colorectal Cancer;Complex;Computed Tomographic Colonography;Computer Simulation;cost;Data;Data Set;design;Detection;Development;Device or Instrument Development;Diagnosis;Disease;Education;Endoscopes;Evaluation;Feedback;Friction;Geometry;Goals;Health;Health Care Costs;health care quality;Hospitalization;human study;improved;innovation;instrument;interactive feedback;Intubation;iterative design;Knowledge;large datasets;Learning;Light;Malignant Neoplasms;Manikins;Measures;Medical;Medical center;Medical Education;Medical Residency;Methods;minimally invasive;Modeling;novel;Operative Surgical Procedures;Organ;patient safety;Patients;personalized learning;Physicians;Polyps;Procedures;programs;Research Personnel;Residencies;screening;sensor;simulation;skills;success;System;Technical Expertise;Techniques;Testing;The Cancer Imaging Archive;Time;Tissues;Trainers Training;Training;Training Programs;Training Technics;Trauma;user-friendly;Validation;Variant;virtual assessment;virtual coach;virtual patient;Visualization;Work

PROJECT_TITLE: Advanced Colonoscopy Training Developed Through Manikin Sensorization and Computational Optimization Modeling

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Lung;Pulmonary Fibrosis;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: Narrative  Using single-cell RNA-sequencing to analyze the lungs of patients with pulmonary fibrosis, we have recently identified a novel distal basal cell population with profibrotic features in the lungs of patients with pulmonary fibrosis. Independent work in our group studying families with pulmonary fibrosis has identified mutations in an orphan receptor (GPR87) as a new PF risk gene; remarkably, and our preliminary data suggest GPR87 is predominantly expressed in these pathologic distal basal cells and may regulate their function. Utilizing innovative transgenic mouse, organoid and inducible pluripotent stem cell (iPSC)-based models, we will investigate the mechanisms through which GPR87 contributes to fibrotic susceptibility and adaptive versus pathologic lung epithelial repair.

PI_NAMEs: KROPSKI, JONATHAN ANDREW (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: 3-Dimensional;Acute;Air;airway epithelium;Alleles;Alveolar;alveolar epithelium;Atypical hyperplasia;Basal Cell;Bleomycin;Cell Differentiation process;Cell Physiology;cell type;Cells;Chronic;Clinical;comparison control;CRISPR/Cas technology;Data;directed differentiation;Disease;Distal;Dose;Epithelial Cells;epithelial repair;Epithelium;epithelium regeneration;Exhibits;exome sequencing;experimental study;Extracellular Matrix;Family;Family Study;Fibrosis;fibrotic lung;G-Protein-Coupled Receptors;Gene Expression;gene-editing approach;Genes;Genetic;Genomic approach;Human;Human Cell Line;in vivo;induced pluripotent stem cell;Influenza;Injury;innovation;Interstitial Pneumonia;Liquid substance;loss of function;Lung;Lung Diseases;Modeling;Mus;mutant;Mutation;novel;Organoids;Orphan;Pathogenesis;Pathologic;Pathway interactions;Patients;Peripheral;Play;Population;Predisposition;programs;Proliferating;Pulmonary Fibrosis;rare variant;receptor;Regulation;repaired;risk variant;Role;segregation;Series;single-cell RNA sequencing;stem cell model;Structure of parenchyma of lung;Syndrome;System;Testing;time use;Tracheal Epithelium;Transgenic Mice;Transgenic Organisms;Work

PROJECT_TITLE: Mechanisms of epithelial repair and remodeling in pulmonary fibrosis

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative We have seen in the current SARS-CoV-2 pandemic, as for all major pathogen outbreaks in the last decade, how phylogenetic (i.e. evolutionary tree) methods are required to use viral genomic information to under- stand large-scale transmission patterns. However, current phylogenetic methods have two major limitations as a tool for viral control: ﬁrst, rigorous Bayesian probabilistic methods cannot scale to 1,000s of genomes, and second, models incorporating phylogenetic trees must be expressed in specialized phylogenetics pack- ages, making modern machine-learning approaches impossible. In this proposal, we develop variational ap- proaches to phylogenetics, which will allow fast inference and procedures to rapidly update inferences when new data arrives, as well as making phylogenetic trees a ﬁrst-class inferential object in major machine-learning packages. 1

PI_NAMEs: MATSEN, FREDERICK ALBERT (contact)

PROGRAM_OFFICER_NAME: GEZMU, MISRAK

PROJECT_TERMS: Algorithms;cloud based;Code;Collection;Complex;Computational Biology;COVID-19 pandemic;Custom;Data;data integration;data modeling;Data Set;Diagnostic;Discipline;Disease;Disease Outbreaks;Epidemic;epidemiologic data;Exclusion;flexibility;Foundations;Friends;Functional disorder;Genome;genomic data;Graph;Heterogeneity;high dimensionality;insight;knowledgebase;Learning;Libraries;Location;Machine Learning;machine learning framework;marginalization;Markov chain Monte Carlo methodology;mathematical methods;Mathematics;Methods;migration;Modeling;Modernization;Modification;Nature;neural network;Neural Network Simulation;novel strategies;open source;pathogen;Pattern;Phylogenetic Analysis;Predisposition;prevent;Procedures;Public Health;Research Personnel;Sampling;scalable algorithms;scale up;Statistical Models;Structure;Technology;TensorFlow;theories;Time;tool;Training;transmission process;Trees;Uncertainty;Update;user-friendly;Viral;viral epidemic;Viral Genome;viral genomics;viral transmission;Work;Writing

PROJECT_TITLE: Fast and flexible Bayesian phylogenetics via modern machine learning

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Health Services;Infectious Diseases;Patient Safety;Prevention

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Antibiotic-resistant bacteria are responsible for over 2.8 million infections and 35,000 deaths each year in the United States. This proposal aims to develop a method that integrates multiple data sources to determine how pathogens are spreading within a healthcare facility. This will provide improved evidence that is necessary to target key steps on the transmission pathway and implement more targeted measures to control healthcare- associated pathogens.

PI_NAMEs: KEEGAN, LINDSAY T. (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Address;analog;antimicrobial;Bacteria;Bacterial Antibiotic Resistance;Bacterial Infections;Bayesian Analysis;Beds;Biometry;career;Centers for Disease Control and Prevention (U.S.);Cessation of life;Clostridium difficile;Communicable Diseases;Communities;Data;Data Analyses;data modeling;Data Set;Ensure;Enterobacteriaceae;Environment;Epidemiologic Methods;Epidemiologist;Epidemiology;Equipment;Event;Failure;flexibility;Future;Genomic approach;genomic data;genomic epidemiology;Genomics;Goals;Hand;Health care facility;health care model;Health Personnel;Healthcare;healthcare-associated infections;Hospitals;improved;Infection;infection burden;Infection Control;Infection prevention;infectious disease model;innovation;Knowledge;Leadership;mathematical model;Measures;Mediating;Medical;Mentored Research Scientist Development Award;Mentors;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;Movement;multiple data sources;network models;Outcome;pathogen;pathogen genomics;Pathway interactions;Patient Transfer;Patients;Phylogenetic Analysis;Physicians;prevent;Probability Theory;Public Health;Publishing;Recording of previous events;Research;Research Personnel;Risk;Role;skills;Source;stem;Study models;Surface;Testing;Translational Research;transmission process;Trees;Uncertainty;United States;Universities;Utah;Vancomycin resistant enterococcus;Virus;ward;Work

PROJECT_TITLE: A combined epidemiologic and genomic approach to identify and control transmission events of hospital associated infections


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Public Health Relevance: All life requires some form of nitrogen to function, and although the atmosphere is comprised of roughly 78% of dinitrogen (N2), it is biologically unavailable without reduction by nitrogenase enzymes, which convert unreactive N2 to a biologically-available form for uptake. The intimate details of this critical (and difficult) transformation are not understood, and although biological studies on the enzyme have demonstrated a critical role of cooperative interactions by nearby amino acid residues and a multi-metallic enzyme core, we do not know the intimate molecular details. This project aims to develop a molecular level understanding of these cooperative effects on substrate activation, which in addition to contributing important mechanistic details that govern nitrogenase function, may also translate into new catalyst development for organic and inorganic transformations.

PI_NAMEs: SZYMCZAK, NATHANIEL KOLNIK (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Acids;Active Sites;Address;Amino Acids;Ammonia;analog;Atmosphere;base;Binding;Biological;Biological Availability;biological systems;catalyst;Communities;Complex;design;Development;Electron Transport;Electrons;Environment;Enzymes;Hydrogen Bonding;Knowledge;Knowledge acquisition;Life;metallicity;Molecular;Molecular Structure;Nitrogen;Nitrogenase;Nutrient;Process;Protons;public health relevance;rational design;Role;Series;small molecule;System;Testing;Translating;uptake

PROJECT_TITLE: The Role of Secondary Interactions Relevant to Biological Reductions of Small Molecules

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(55)R]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Microbiome;Nutrition

ORG_CITY: SAN FRANCISCO

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Periodontal disease (PD) is caused by unhealthy bacteria and plaque accumulation in the mouth leading to inflammation of periodontal tissues. The role of diet in PD progression is currently not well understood, yet is critical to better understanding disease progression and the development of new therapeutic approaches. This project proposes a novel approach to better understand how diet, particularly processed wheat grains, contributes to PD onset by altering bacteria, plaque accumulation, and periodontal inflammation in the mouth.

PI_NAMEs: SEDGHI, LEA MARYAM (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: 16S ribosomal RNA sequencing;Actinomyces;Adoption;Affect;Alveolar Bone Loss;Amylases;Automobile Driving;Bacteria;beta catenin;Biological Availability;Bite Force;carbohydrate metabolism;Carbohydrates;Cells;Communities;Complementary DNA;Consumption;Data;Debridement;Development;Diet;Digestion;Disease;Disease Progression;dysbiosis;E-Cadherin;Energy Intake;Epithelial Cells;Excision;Flow Cytometry;Fluorescent in Situ Hybridization;Food;Forsythia;Fusobacterium nucleatum;Gene Expression;Genetic Transcription;Gingiva;Grain;Growth;Harvest;Hydrolysis;Immune;Immune response;Immunity;Immunohistochemistry;improved;In Vitro;in vivo;in vivo Model;Incidence;Infection;Inflammation;Inflammatory Response;Investigation;light microscopy;mandible/maxilla;Mastication;Mechanics;microbial;Microbial Biofilms;microbial colonization;microbiome;Microfluidics;Modeling;Mus;novel strategies;novel therapeutic intervention;novel therapeutics;Nutritional;Onset of illness;Oral;Oral cavity;oral microbial community;oral microbiome;Outcome;particle;pathogen;Periodontal Diseases;Periodontal Ligament;periodontopathogen;Phase;Physiological;polymicrobial biofilm;Population;Porphyromonas gingivalis;Predisposition;Prevention;Process;Property;response;RNA;Roentgen Rays;Role;Salivary;Site;Soft Diet;Standardization;Starch;Streptococcus gordonii;Streptococcus sanguis;Structure;Surface;System;Texture;Tissues;tomography;Transcript;transcriptome sequencing;Transmission Electron Microscopy;Treponema denticola;virulence gene;Western Blotting;western diet;Wheat

PROJECT_TITLE: The Effect of Processed Grain Consumption on the Dentogingival Microbiome and Host Response in Periodontal Disease

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: LAWRENCE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: NARRATIVE Interactions between carbohydrates and proteins in biological systems play important roles in cellular proliferation, viral and bacterial pathogenesis, cell-cell recognition, fertilization, embryogenesis, neuronal development, and hormonal activities. Despite the importance in human physiology and pathophysiology, the study of carbohydrate-protein interactions remains challenging and highly specialized. In this proposal we describe the development of new tools that are needed to discover, study, and probe carbohydrate protein interactions.

PI_NAMEs: FARRELL, MARK PATRICK (contact)

PROJECT_TERMS: Address;Affinity;Binding;Biochemical;Biological Assay;biological systems;Biology;biophysical techniques;carbohydrate binding protein;carbohydrate receptor;Carbohydrates;Cell Proliferation;Cells;Communities;Covalent Interaction;Development;Disease;Embryonic Development;Enzyme-Linked Immunosorbent Assay;Fertilization;Functional disorder;Glycobiology;Hormonal;Human;Label;Ligands;Mediating;neuron development;Pathogenesis;Pathway interactions;Physiology;Play;Polysaccharides;Process;Protein-Carbohydrate Interaction;Proteins;Role;Sorting;Techniques;Technology;Therapeutic;tool;Viral

PROJECT_TITLE: Glycoscience Tools and Therapeutics


ORG_CITY: LA JOLLA

ORG_NAME: LA JOLLA INSTITUTE FOR IMMUNOLOGY

PHR: Narrative Immunological diseases affect millions of people in the United States. There is a great need for PhD and MD scientists to advance our understanding of immunologic mechanisms related to autoimmune, inflammatory, and infectious disease, and cancer, and to translate findings from bench to bedside. The program will train future academic and industry leaders in approaches relevant to understanding how to modify the immune system to improve health.

PI_NAMEs: CROFT, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Immunologics;Training

PROJECT_TITLE: Training in Immunological Mechanisms

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Burden of Illness;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative LifeAfter90 is a newly launched cohort study of diverse individuals aged 90+ which has successfully enrolled and followed 908 research participants in 36 months. The continuation of LifeAFter90 will provide not only new information on dementia, and brain neuropathology but will also reveal early life contributions and risk factors for both cognitive `Super-Agers” and cognitive impairment. Renewal of LA90 will create an unprecedented scientific resource for studying Alzheimer's disease and cognitive outcomes in a diverse cohort of oldest-old individuals, a group representing the rapid diversification of this population.

PI_NAMEs: CORRADA, MARIA ;GILSANZ, PAOLA ;WHITMER, RACHEL A (contact)

PROGRAM_OFFICER_NAME: PERCY-LAURRY, ANTOINETTE LOIS

PROJECT_TERMS: Age;age related;aged;aging brain;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Asian;Atrophic;Autopsy;Biological Markers;Black race;Blood Vessels;blood-based biomarker;Brain;Brain Pathology;California;cardiovascular risk factor;cerebral atrophy;Child;Clinical Data;clinical examination;Cognition;Cognitive;Cognitive aging;cognitive change;cognitive performance;cohort;Cohort Studies;comorbidity;COVID-19;COVID-19 pandemic;Data;Dementia;Early identification;Education;Elderly;Enrollment;Epidemiology;Ethnic Origin;ethnoracial;experience;Exposure to;Female;Glial Fibrillary Acidic Protein;Goals;Health;health data;health inequalities;Heterogeneity;high school;Image;Impaired cognition;Incidence;Individual;Interview;Language;Latino;Learning;Life;Life Cycle Stages;Life Experience;lifestyle data;Light;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;men;middle age;mild cognitive impairment;multi-ethnic;multi-racial;Multilingualism;Nerve Degeneration;neurofilament;neuroimaging;neuroimaging marker;neuropathology;Neuropsychology;Not Hispanic or Latino;Older Population;Outcome;Participant;participant enrollment;Pathology;Pattern;Persons;Population;Positioning Attribute;Positron-Emission Tomography;programs;prospective;protective factors;protein TDP-43;Psychosocial Factor;Race;racial diversity;Research;research clinical testing;Resources;Risk Factors;Science;sex;social;super ager;tau Proteins;Telephone;vascular injury;vascular risk factor;Visit;Woman

PROJECT_TITLE: Epidemiology of Age-related Dementia, Mild Cognitive Impairment and Brain Pathology in a Multiethnic Cohort of Oldest-Old

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-C(02)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

PHR: Project Narrative A major problem with current influenza vaccines is that the viruses that cause influenza evolve rapidly, and people may be infected with viruses that are different from the ones used to make the vaccine. The proposed research will lead to a greater understanding of how influenza viruses evolve and transmit in people. This work is relevant to public health, because it will allow for the development of better influenza vaccines and more effective vaccination programs.

PI_NAMEs: LAURING, ADAM  (contact);MARTIN, EMILY TOTH

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Affect;Age;Animal Model;Antibodies;Antibody titer measurement;Characteristics;chronic infection;Clinical Data;cohort;Communicable Diseases;Communities;community setting;Community-Acquired Infections;cross reactivity;Data;Development;Enrollment;epidemiologic data;Epidemiology;Evolution;flu transmission;Foundations;genetic variant;Genetic Variation;Goals;hazard;Hazard Models;Hemagglutinin;Household;Human;Immune;Immunity;Immunization Programs;immunological status;indexing;Individual;Infection;Influenza;influenza epidemic;influenza virus strain;influenza virus vaccine;influenzavirus;innovation;Integration Host Factors;Journals;Knowledge;mathematical model;Measures;Modeling;Molecular;Morbidity - disease rate;mortality;Mutation;National Institute of Allergy and Infectious Disease;Natural Selections;Neuraminidase;next generation sequencing;novel;Persons;Play;Population;Predisposition;pressure;Process;Productivity;Property;Proteins;Public Health;Publishing;rare variant;Research;Resolution;Sampling;seasonal influenza;Single Nucleotide Polymorphism;Strategic Planning;Swab;Technology;tool;transmission process;universal influenza vaccine;universal vaccine;Vaccination;vaccine effectiveness;vaccine efficacy;vaccine-induced antibodies;Vaccines;Variant;Viral;Viral Hemagglutinins;Viral Load result;viral transmission;Virus;whole genome;Work

PROJECT_TITLE: Evolution and Transmission of Influenza Virus in Natural Human Infection


PHR: Narrative: We are seeking funding to support a unique and innovative PhD training program for cross-disciplinary training in quantitative and systems approaches in biomedical science. Primary objectives of the program include: for trainees to attain and demonstrate quantitative and systems analysis skills, to achieve diverse and equitable representation in the program, to facilitate the establishment of collaborative research networks, and to broadly disseminate innovative training and research tools.

PI_NAMEs: BEARD, DANIEL A (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Biology;System;Training Programs

PROJECT_TITLE: Systems and Integrative Biology Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

PHR: Ingestive decisions play a key role in a number of human conditions including obesity, diabetes, anorexia, hypertension, and coronary artery disease. The sense of taste is the most important factor in regulating these ingestive decisions, and therefore plays an important role in human health. The goal of this research is to uncover how taste neophobia learning is organized within central gustatory circuits.

PI_NAMEs: BOUGHTER, JOHN D (contact);FLETCHER, MAX L

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Acetylcholine;Acute;Adverse effects;adverse outcome;Agreement;Animals;Anorexia;Area;attenuation;awake;basal forebrain;Basal Nucleus of Meynert;Behavior;Behavioral;Brain region;Calcium;cell type;Cells;Child;Child Health;Childhood;cholinergic;cholinergic neuron;Consumption;Coronary Arteriosclerosis;Data;Desire for food;Diabetes Mellitus;dietary;Disease;Dissection;Eating Disorders;Ensure;experience;experimental study;Exposure to;Failure;Familiarity;Feeding behaviors;Food;Genetic;genetic approach;genetic manipulation;Genetic Techniques;Goals;Head;Health;Human;Hypertension;Image;Immediate-Early Genes;Intake;Knowledge;Learning;Lesion;Measures;Mediating;Memory;microendoscope;Mus;neural;neural circuit;neural correlate;neuromechanism;neuronal circuitry;Neurons;Neurotransmitters;novel;novelty processing;Obesity;Pathway interactions;Pharmacology Study;Phase;Play;poor health outcome;Population;Primary Lesion;Process;Prosencephalon;Reaction;Research;response;Rodent;Role;Sensory;Signal Transduction;Stimulus;Taste Perception;taste stimuli;Techniques;Testing;Thalamic structure;Time;Toxic effect;transmission blocking

PROJECT_TITLE: The Neural Organization of Taste Neophobia

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ORG_CITY: MENANDS

ORG_NAME: WADSWORTH CENTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE  The proposed research is relevant to public health because the malfunction of intra-flagellar transport (IFT) results in defects in primary cilium maintenance and abnormities in trafficking of signaling molecules that are associated with a variety of medical disorders, including developmental disorders, cancers and cystic diseases. The knowledge to be gained is essential for understanding the functional roles of IFT in structural assembly and maintenance of primary cilia and molecular trafficking in primary cilia. This knowledge will guide the development and evaluation of molecular therapies to ameliorate these primary cilium-related disorders.

PI_NAMEs: SUI, HAIXIN  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TITLE: Intraflagellar transport process in primary cilium maintenance

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Nutrition;Obesity;Physical Activity;Prevention;Prostate Cancer;Rehabilitation;Urologic Diseases

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Relevance Nearly half of the 3 million prostate cancer survivors in the U.S. were prescribed androgen deprivation therapy that increases their risk of becoming obese and frail. The proposed study determines whether a combination of a web-based lifestyle management program plus online supervised group resistance training can reduce obese frailty. We will also collect preliminary data on a set of implementation outcomes to guide future research testing the implementation of iLIVE into the clinical care pathway

PI_NAMEs: DEMARK-WAHNEFRIED, WENDY ;WINTERS-STONE, KERRI M (contact)

PROGRAM_OFFICER_NAME: PERNA, FRANK

PROJECT_TERMS: Acceleration;Address;Affect;African American;Age;American Society of Clinical Oncology;androgen deprivation therapy;arm;Behavioral;Body mass index;Body Weight decreased;cancer survival;Cancer Survivor;Caring;Clinical;clinical care;clinical practice;combat;cost;Data;design;Diet;dietary;Dietary Intervention;disability;Dose;effective intervention;Effectiveness of Interventions;effectiveness testing;effectiveness/implementation trial;Exercise;exercise intervention;fall risk;falls;Fatigue;Fatty acid glycerol esters;follow-up;Foundations;frailty;functional decline;Functional disorder;future implementation;Guidelines;Health;Health Care Costs;health economics;high risk population;Hospitalization;Hybrids;implementation outcomes;implementation science;implementation strategy;Individual;innovation;Internet;Intervention;intervention effect;Life Style;lifestyle intervention;Measures;men;Morbidity - disease rate;mortality;multidisciplinary;Muscular Atrophy;National Comprehensive Cancer Network;nutrition;Obesity;older adult;Oncology;oncology trial;online delivery;Online Systems;Outcome;Pathway interactions;Persons;Phenotype;Physical activity;Physical Function;Populations at Risk;Practice Guidelines;Prevalence;primary endpoint;Principal Investigator;Proctor framework;programs;prostate cancer prevention;prostate cancer progression;prostate cancer survivors;Public Health;Quality of life;Race;Randomized;recruit;Recurrence;remote delivery;resistance exercise;Risk;Rural;sarcopenia;Science;secondary outcome;Self Direction;Solid;Speed;standard care;Testing;theories;Therapeutic;Training;Training Programs;treatment as usual;tumor progression;Underrepresented Populations;Urology;Videoconferencing;Weight Gain;weight loss program;Weight maintenance regimen;Work

PROJECT_TITLE: Internet-Based Lifestyle Intervention to Eradicate Obese Frailty in Prostate Cancer Survivors (iLIVE)

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Public Health Narrative: Infectious diseases are responsible for reduced quality of human life, morbidity, and are taxing to the USA and global economy. To date, there are many infectious diseases that lack appropriate treatment options while current treatment regimens can often be less efficacious due to pathogen resistance. Training of pre-doctoral students at the interface of infectious diseases and drug discovery will have an impact on the number of new scientists harboring skills and determination to address critical gaps in treatment of infectious diseases.

PI_NAMEs: STAHELIN, ROBERT VIRGIL (contact);YEO, YOON

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TITLE: Drug Discovery in Infectious Disease Training

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Substance Misuse

ORG_CITY: RICHMOND

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Alcoholic hepatitis, the clinically most devastating presentation of alcoholic liver disease (ALD), is a significant global health problem, which has no effective therapeutics due to limited understanding of the mechanisms of disease progression, and liver transplantation remains the only curative option. The focus of this is the roles of sphingosine kinase 2 (SphK2)/sphingosine-1 phosphate (S1P)-mediated signaling pathways in alcohol-induced liver injury. Completion of this study will not only identify the potential cellular/molecular mechanisms involved in the initiation and progression of ALD but will also make a significant conceptual advance linking bile acids and SphK2 with alcoholic liver injury, which will create a fundamental base for developing novel therapies for ALD and a reduction of morbidity/mortality in patients with alcoholic hepatitis.

PI_NAMEs: HYLEMON, PHILLIP B;ZHOU, HUIPING ROSE (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Acute;alcohol response;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Alveolar Macrophages;Bacterial Translocation;base;bile acid metabolism;Bile Acids;Cell Nucleus;cell type;Chronic;chronic liver disease;Cirrhosis;Clinical;clinical application;curative treatments;Cytoplasm;Data;Development;Disease;Disease Progression;Epithelial Cells;Fatty Acids;Fatty Liver;FDA approved;feeding;G-Protein-Coupled Receptors;Genes;Genetic Transcription;global health;glucose metabolism;Growth;gut microbiome;gut-liver axis;HDAC1 gene;Hepatic;Hepatocyte;Heterogeneity;High Fat Diet;Histone Acetylation;Histone Deacetylase Inhibitor;Inflammatory;Inflammatory Response;inhibitor;intestinal barrier;intestinal epithelium;Intestinal permeability;Intestines;ITGAM gene;Knock-out;Knockout Mice;Leaky Gut;Ligands;Link;lipid metabolism;Lipids;Liver Fibrosis;liver inflammation;liver injury;liver transplantation;LoxP-flanked allele;Macrophage;Mammalian Cell;MAPK3 gene;Mediating;Metabolic Diseases;Mitochondria;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Myeloid Cells;National Institute on Alcohol Abuse and Alcoholism;novel;novel therapeutic intervention;novel therapeutics;Nuclear;Organelles;Organoids;Pathogenesis;Patients;Phospholipase;Play;Predisposition;problem drinker;Production;Proto-Oncogene Proteins c-akt;Reporting;response;Role;Signal Pathway;Signal Transduction;Signaling Molecule;single nucleus RNA-sequencing;Sphingolipids;Sphingosine;sphingosine 1-phosphate;sphingosine kinase;Sphingosine-1-Phosphate Receptor;SPHK1 enzyme;Stimulator of Interferon Genes;Stress;systemic inflammatory response;Testing;therapeutically effective;Tissues;transcriptome sequencing

PROJECT_TITLE: Sphingolipids in alcoholic liver disease

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Parasitic diseases are responsible for millions of deaths in addition to severe and subtly morbidity and there are no effective vaccines or drug treatments to combat them. Understanding how parasites cause disease requires researchers and practitioners with high level of training. The Training in Tropical and Emerging Global Diseases program offers advanced training and professional development of talented predoctoral and postdoctoral trainees to prepare them for careers dedicated to fighting parasite pathogens.

PI_NAMEs: KYLE, DENNIS E;MORENO, SILVIA N (contact)

PROJECT_TERMS: Disease;Training

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: ORLANDO

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

PHR: PROJECT NARRATIVE Malaria is one of the major global health problems afflicting about 229 million people and causing over 400,000 deaths annually. Because of the emergence of drug resistance parasites, current therapies for malaria are rapidly losing their efficacy. The proposed research seeks to identify novel antimalarial lead compounds targeting parasite protein kinases effective against multidrug resistant malaria with therapeutic and prophylactic properties, thus contributing to the global malaria elimination campaign.

PI_NAMEs: CHAKRABARTI, DEBOPAM  (contact);GRAY, NATHANAEL SCHIANDER;WINZELER, ELIZABETH A

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Address;Affect;Africa;Aminopyridines;analog;Animal Model;Anti-Infective Agents;Anti-malarials;Appearance;Artemisinins;asexual;Binding Sites;Biochemical;Biological;Biological Assay;Biology;Blood;California;cancer therapy;Cellular biology;Cessation of life;Chemicals;Child;Collaborations;Collection;Combined Modality Therapy;Copy Number Polymorphism;Cyclic AMP-Dependent Protein Kinases;design;Development;Dose;drug development;Drug Industry;Drug resistance;efficacy evaluation;Erythrocytes;Evaluation;Evolution;Exhibits;Falciparum Malaria;FDA approved;Florida;genome sequencing;global health;Goals;human disease;humanized mouse;Hydrophobicity;improved;In Vitro;in vivo;Infection;inhibitor;inhibitor therapy;Interdisciplinary Study;kinase inhibitor;knock-down;Knowledge;Laboratories;Lead;Lipids;Liver;Malaria;Methods;Modeling;Molecular;Molecular Conformation;Molecular Target;mouse model;Multi-Drug Resistance;Mus;nanomolar;next generation;novel;Oncogenic;optimism;Parasite resistance;Parasites;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;pharmacophore;Phenotype;phosphoproteomics;Phosphorylation;Phosphotransferases;Plasmodium;Plasmodium falciparum;Plasmodium falciparum genome;Plasmodium vivax;Population;Predisposition;Property;prophylactic;Prophylactic treatment;Protein Kinase;protein kinase inhibitor;Proteins;pyridine;Relapse;Reporting;Research;Resistance;Resistance profile;resistant strain;Resources;Route;scaffold;screening;Signal Pathway;small molecule therapeutics;Source;Southeastern Asia;targeted treatment;Testing;Therapeutic;Thiophenes;Universities;Validation;whole genome

PROJECT_TITLE: Plasmodium Protein Kinase Focused Antimalarials Discovery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-V(02)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it contributes to laying the groundwork for the development of a new strategy to treat cancer by simultaneously utilizing DNA-targeted genotoxic therapy and the inhibition of critical proteins in a DNA damage repair pathway that is facilitated by homologous recombination (HR). HR in tumor cells is associated with accelerated resistance to chemo- and radiotherapy, and with recurrence of disease. The research proposed here aims to identify promising target molecules for inhibition in HR and, as such, is relevant to the NIH’s mission that pertains to increasing our understanding of the biological processes that will lead to advances in the treatment of disease.

PI_NAMEs: WIESE, CLAUDIA  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Acceleration;Anaphase;anti-cancer therapeutic;ATP phosphohydrolase;Biochemical;Biological Assay;Biological Process;C-terminal;Cancer cell line;cancer therapy;Cell Survival;Cells;chemotherapeutic agent;chemotherapy;Chromosome abnormality;Chromosome Pairing;Chromosomes;Complement;Complex;Cytoprotection;cytotoxicity;Development;Disease;DNA;DNA Damage;DNA fiber assay;DNA Repair;ds-DNA;Event;Exhibits;Filament;Genetic Complementation Test;Genetic Recombination;Genome Stability;genotoxicity;Goals;homologous recombination;homologous recombination deficiency;Human;Individual;inhibitor;innovation;Invaded;Investigation;Knock-out;Knowledge;loss of function;Malignant Neoplasms;Maps;Mediating;Mission;Molecular;Mutagens;mutant;Natural Killer Cells;neoplastic cell;novel;novel therapeutics;Nucleosomes;Outcome;paralogous gene;Pathway interactions;Phenotype;postsynaptic;protein complex;Proteins;Public Health;RAD54L gene;Radiation therapy;Reaction;Recurrent disease;repaired;Reporter;Research;Resistance;Resistance development;Resolution;response;RNA;Role;Route;Single-Stranded DNA;synthetic construct;targeted treatment;telomere;Telomere Pathway;Testing;tumor;Ultrafine;United States National Institutes of Health

PROJECT_TITLE: Mechanisms of chromosome damage repair in human cells

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Aging;Biotechnology;Contraception/Reproduction;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Urologic Diseases

PHR: PROJECT NARRATIVE/REVELANCE TO PUBLIC HEALTH This proposal aims to delineate the molecular mechanism underlying human testis aging through a combination of single-cell genomics, molecular and cell biology approaches. Recent data has demonstrated multiple degenerative changes in human reproductive tissues during aging, which can also be transmitted to the offspring and cause inherited disorders. Therefore, defining and understanding the molecular drivers of human testis aging has great implications for human reproductive health and wellness of the offspring.

PI_NAMEs: CAIRNS, BRADLEY R. (contact)

PROGRAM_OFFICER_NAME: WANG, FEI

PROJECT_TERMS: Achondroplasia;Adult;Age;age related changes;Age related pathologies;age stratification;aged;Aging;aging mechanism;ATAC-seq;Autopsy;bioinformatics pipeline;Biological Assay;Body mass index;cell age;Cells;Cellular biology;Child;Chromatin;Data;Data Set;Deterioration;Developed Countries;Development;Disease;DNA Methylation;DNA methylation profiling;Elderly;Endothelium;Epigenetic Process;epigenome;experimental study;Fertility;Gene Expression;Genetic;Genetic Transcription;genome integrity;genome wide methylation;Genomic approach;Genomics;Germ Cells;Germ Lines;Health;Hereditary Disease;high body mass index;high risk;Human;human male;Impairment;In Vitro;Individual;Infertility;Link;Macrophage;Maintenance;male;Malignant neoplasm of testis;Malignant Neoplasms;men;Molecular;Molecular Biology;Morphology;Mutation;Nucleic Acid Regulatory Sequences;offspring;Organ;Organoids;Parental Ages;Paternal Age;Pattern;Physiological;Physiology;preservation;Puberty;Public Health;reproductive;Reproductive Health;Risk;Risk Factors;Sampling;Series;single cell analysis;single cell ATAC-seq;single cell genomics;single-cell RNA sequencing;socioeconomics;sperm cell;Spermatids;Spermatocytes;Spermatogonia;stem cells;Structure;Syndrome;System;Techniques;Testing;Testis;Tissues;transcriptome sequencing;transmission process;trend;Validation;Work;Xenograft procedure;young adult

PROJECT_TITLE: Molecular, Epigenetic and Genomic Approaches to Understand Mechanisms of Aging in the Human Testis


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Microbiome;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed study will investigate milestones of oral microbiome development among Latinx infants who were born along the United States-Mexico border and have high risk for oral diseases. By contributing to new knowledge about the development of oral microbiome and modeling the association between pediatric microbial development and dental diseases, we may gain scientific insight to produce early prevention programs that can reduce dental disease risk and eventually prevent significant oral health disparities for this population. Understanding the dynamic changes of the oral microbiome may provide an innovative solution for personalized, predictive, and preventive pediatric dentistry.

PI_NAMEs: WANG, YAN  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: 16S ribosomal RNA sequencing;Adult;Age;Algorithms;Allergic Disease;Antibiotics;autism spectrum disorder;Bacteria;biomarker discovery;biomarker identification;Birth;Breast Feeding;Cardiovascular Diseases;career;career development;Caregivers;Child;Child Health;Childhood;Chlorhexidine;Chronic;Collaborations;Complex;Control Groups;Counseling;County;Data;deciduous tooth;Dental caries;Dentistry;Development;Diet;Disease;disorder risk;early childhood;Early Intervention;Ecosystem;Environment;ethnic disparity;evidence base;experience;Foundations;Freezing;Funding;fungus;Future;Goals;Health;health disparity;health disparity populations;Healthcare;High Prevalence;high risk;Hispanic;Hispanic Populations;Horizontal Disease Transmission;Human;immune function;Infant;innovation;insight;Intervention;kindergarten;Knowledge;Latinx;Life;Literature;Los Angeles;Measures;medical schools;Mentored Research Scientist Development Award;Mentors;Mentorship;Mexico;Microbe;microbial;microbiome;microbiome composition;microbiome research;microbiota;microorganism;Modeling;Modernization;Mothers;Mouth Diseases;Neonatal;Newborn Infant;Oral;Oral cavity;Oral Characters;Oral health;oral microbial community;oral microbiome;Oral mucous membrane structure;Outcome;Parents;Participant;Pattern;Pediatric Dentistry;peer;personalized therapeutic;Placenta;Placental microbiome;Play;Population;Postpartum Period;Pregnancy Complications;prenatal;Preschool Child;prevent;Prevention program;Preventive;Proxy;Public Health;Qualifying;racial disparity;randomized, clinical trials;Regimen;Research;Research Activity;research and development;Research Personnel;risk prediction;Role;saliva sample;Sampling;Schedule;School Dentistry;Second Pregnancy Trimester;Statistical Data Interpretation;Surface;Surveys;Techniques;Therapeutic;Time;Tooth Diseases;Tooth structure;Training;transmission process;treatment group;United States;United States National Institutes of Health;Virus;Visit;Weight Gain;Work;Youth

PROJECT_TITLE: Oral microbiome establishment and development of Latinx Children at the US-Mexico border


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Diabetes;Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The proposed study aims to uncover the roles of retinal Müller glial cells in initiating diabetic retinopathy, focusing on dissecting their protective effects. This work will open new directions and possibilities for the development of novel therapeutic approaches.

PI_NAMEs: WANG, SUI  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Ablation;Age;Apoptosis;Blindness;Blood Vessels;Candidate Disease Gene;cell type;Cells;cellular targeting;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Complications of Diabetes Mellitus;CRISPR/Cas technology;Defect;Dependovirus;Development;diabetes control;Diabetes Mellitus;diabetic rat;Diabetic Retinopathy;Disease;effective therapy;Failure;first responder;Genes;Genetic Transcription;Germ Cells;Gliosis;Homeostasis;Homologous Gene;Human;Immune system;improved;in vivo;in vivo Model;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;Knowledge;Lesion;Messenger RNA;Modeling;Molecular;neovascularization;Nerve Degeneration;Neuroglia;Neurons;neurovascular;novel;novel therapeutic intervention;novel therapeutics;overexpression;oxidation;Oxidative Stress;Play;Population;prevent;Proliferating;protective effect;protective pathway;Proteins;Rattus;response;Retina;Retinal Diseases;retinal neuron;RNA-Binding Proteins;Role;single-cell RNA sequencing;Symptoms;System;Testing;therapeutic candidate;therapeutically effective;tool;transcriptomics;Up-Regulation;Work;Zinc Fingers

PROJECT_TITLE: Retinal Muller Glial Cells in the initiation of diabetic retinopathy

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: Deep learning shifts method development from hand-engineered models and pipelines to flexible models that can achieve state-of-the-art performance and learn complex patterns directly from the data. In this proposal we aim to leverage the potential of deep learning for the problem of SV discovery by developing a framework to call and genotype germline and somatic SVs, including complex variants, using data from different sequencing platforms. Improving SV detection will have a significant impact on our ability to characterize, diagnose, and treat a wide range of diseases driven by SVs, such as cancer and numerous neurological, autoimmune, and cardiovascular disorders.

PI_NAMEs: POPIC, VICTORIA  (contact)

PROGRAM_OFFICER_NAME: ARGUELLO, ALEXANDER

PROJECT_TERMS: Algorithms;Alzheimer's Disease;Architecture;autism spectrum disorder;Autoimmune Diseases;Benchmarking;blind;cancer genome;Cardiovascular Diseases;Categories;Clinical;Communities;Complex;Computer software;Computer Vision Systems;Consensus;convolutional neural network;Coupled;Data;data platform;Data Reporting;Data Set;deep learning;deep learning model;deep neural network;design;Detection;Development;Diagnosis;Dimensions;Disease;Engineering;engineering design;Evaluation;experimental study;flexibility;Formulation;Generations;Genetic;Genetic Diseases;Genetic Variation;Genome;genome sequencing;genomic data;Genotype;Germ Lines;Goals;Hand;Hand functions;heuristics;Hi-C;Human Genetics;Human Genome;Hybrids;Image;improved;Learning;Link;Machine Learning;Malignant Neoplasms;Manuals;Medicine;method development;Methodology;Methods;Mind;model building;Modeling;Nervous System Disorder;neural network;Pattern;Performance;Play;pre-trained model;precision medicine;Property;prototype;Research;Resolution;Role;Sampling;Science;Sequence Alignment;sequencing platform;Signal Transduction;simulation;Source;Statistical Models;Structural Models;Structure;Techniques;Technology;Training;training data;tumor;Variant;variant detection;whole genome;Work

PROJECT_TITLE: Cross-platform structural variant discovery with deep learning

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Small proteins, making up the majority of the proteome, are responsible for many devastating diseases, including cancer, cardiac arrhythmias and drug addiction. Due to their size, these proteins cannot be studied effectively by cryogenic electron microscopy (cryoEM), a technique allowing for proteins to be studied at native conditions more relevant to our understanding of function and disease causation. The proposed work is relevant to public health because we develop methods to break these size barriers and then study disease-associated proteins by cryoEM to aid in structure-guided drug design for potentially more effective therapeutics.

PI_NAMEs: GONEN, SHANE  (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Address;Arrhythmia;Binding;Cell Physiology;Cells;Complex;Cryoelectron Microscopy;design;Development;Disease;Drug Addiction;Drug Design;drug development;Environment;Etiology;experimental study;G-Protein-Coupled Receptors;Gatekeeping;human disease;Human Genome;Image;infancy;interest;Ligands;Malignant Neoplasms;Membrane;Membrane Proteins;Methods;nanomaterials;particle;Play;protein complex;Protein Engineering;protein function;protein structure;Proteins;Proteome;Public Health;reconstruction;recruit;Resolution;Role;scaffold;Signal Transduction;structural biology;Structure;Techniques;Testing;therapeutically effective;virtual;Work

PROJECT_TITLE: Breaking barriers in CryoEM through computational protein design

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Infectious Diseases;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE Cytomegalovirus (CMV) is the leading infectious disease cause of congenital viral infections in the newborn and has profound effects on the immune system. In this project we propose to study the metabolic changes induced by maternal CMV infection during pregnancy and its effect on fetal development and immunity.

PI_NAMEs: KAUR, AMITINDER  (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: Acute;Adaptive Immune System;adaptive immunity;Affect;Amniotic Fluid;Animal Model;B-Lymphocytes;Biological;Biological Assay;Biological Markers;Biological Response Modifiers;Birth;Blood;Bone Marrow;Breeding;Cells;Cellular Immunology;Cesarean section;Child;Childhood;Chronic;Communicable Diseases;Comparative Study;congenital cytomegalovirus;congenital infection;cytokine;Cytomegalovirus;Cytomegalovirus Infections;Decidua Basalis;Enrollment;Epigenetic Process;Epilepsy;Exposure to;fetal;fetal blood;Fetal Development;fetal immunity;fetal programming;Fetal Tissues;First Pregnancy Trimester;Flow Cytometry;Genetic;Genus Hippocampus;Grant;hearing impairment;Herpesviridae;Human;human model;Immune;immune function;Immune system;Immunity;Immunocompetent;Immunologics;Impaired cognition;imprint;in utero;Infant;Infection;Inflammation;Inflammatory;Innate Immune System;insight;Knowledge;Leukocytes;Lifelong disability;Lymphocyte;Macaca;Macaca mulatta;Maternal Exposure;Maternal-Fetal Exchange;Maternally-Acquired Immunity;Mediating;Metabolic;metabolic abnormality assessment;Metabolic Pathway;Metabolism;metabolomics;Mitogens;Modeling;Modification;Monitor;monocyte;Monozygotic twins;motor impairment;multiple omics;Mus;Natural Immunity;Natural Killer Cells;Newborn Infant;nonhuman primate;novel;Outcome;Phenotype;Placenta;Population;Population Study;Pregnancy;pregnant;Primary Infection;Primates;prospective;PTPRC gene;Regulatory T-Lymphocyte;Reporting;Research;Rhesus;Role;Second Pregnancy Trimester;seropositive;Seroprevalences;Sorting;Spleen;Stains;T-Lymphocyte;Thymus Gland;transcriptome sequencing;transcriptomics;transmission process;Vaccination;Virus Diseases;Woman;XCL1 gene;young adult

PROJECT_TITLE: CMV infection impact on placental immunometabolism and fetal immunity