NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric;Suicide

ORG_CITY: FAIRFAX

ORG_DEPT: PSYCHOLOGY

ORG_NAME: GEORGE MASON UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative The goal of the proposed research is to illuminate cognitive and neural factors associated with the elevated risk for co-occurring anxiety and depression in young adults (age 18-30 years) with autism spectrum disorder [ASD]. Using structural and functional brain imaging and measures of emotion processing, understudied populations who are at dramatically elevated risk for anxiety and depression will be examined: women and gender diverse adults. Results will advance our understanding of cognitive and brain mechanisms related to elevated risk for anxiety and depression in ASD and inform interventions that will reduce the burden of these serious mental illnesses in autistic individuals.

PI_NAMEs: MCQUAID, GOLDIE ANN  (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Achievement;Address;Adolescent;Adult;adult with autism spectrum disorder;Affect;Age;aged;Alexithymias;Amygdaloid structure;Anxiety;anxiety symptoms;assigned female at birth;Attenuated;autism spectrum disorder;autism symptoms;Awareness;Behavioral;biomarker identification;Birth;bodily sensation;Brain;Brain imaging;career;Child;cisgender;Cognitive;cognitive reappraisal;comorbid depression;completed suicide;Data Set;depressive symptoms;Development;Development Plans;Distress;Down-Regulation;Ecological momentary assessment;emotion dysregulation;emotion regulation;Emotional;emotional experience;Emotions;Environment;Exhibits;expectation;experience;Face;Feeling suicidal;Female;Functional Magnetic Resonance Imaging;Gender;gender diverse;gender diversity;Gender Identity;General Population;Goals;Health;improved;Individual;individuals with autism spectrum disorder;Influentials;Institution;Intellectual functioning disability;Intervention;Label;life span;Magnetic Resonance Imaging;male;Measurement;Measures;Mediating;Mental Depression;Mental Health;Mentors;Mentorship;Methods;Minority;Modeling;Moods;multidisciplinary;multilevel analysis;neural;open data;Outcome;Personal Satisfaction;phenomenological models;Phenotype;Population;Positioning Attribute;Predictive Factor;Predisposing Factor;Prefrontal Cortex;Prevalence;programs;Protocols documentation;psychiatric comorbidity;Research;Research Design;Research Personnel;Research Project Grants;Resources;Risk;Role;Sampling;Scientist;severe mental illness;Severities;sex;sex assigned;sexual identity;Shapes;skills;social;Social Behavior;social deficits;social expectations;Stress;suicidal;Symptoms;Training;trait;Up-Regulation;Woman;young adult

PROJECT_TITLE: Emotion processing, gender identity, and differential risk for anxiety and depression in autistic adults

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Cardiovascular;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Liver Disease;Machine Learning and Artificial Intelligence;Substance Misuse

ORG_CITY: ROCHESTER

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE This study will investigate the natural history of cirrhosis. The success of this proposed research will result in new treatments for patients with cirrhosis.

PI_NAMEs: SHAH, VIJAY H. (contact);SIMONETTO, DOUGLAS A.

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Animal Model;Anticoagulation;Artificial Intelligence;Attenuated;Biological Specimen Banks;Blood Vessels;Cardiovascular system;Cessation of life;circulating biomarkers;Cirrhosis;Clinic;Clinical;Clinical Research;Clinical Trials;Collection;Compensation;Conduct Clinical Trials;Data;Data Coordinating Center;Data Set;Databases;Development;Disease;Disease Progression;effective therapy;efficacy evaluation;efficacy study;efficacy trial;Electrocardiogram;end stage liver disease;Endothelium;Etiology;Event;extracellular;Fibrosis;follow-up;Foundations;Future;Generations;Goals;Hemorrhage;Hepatic;Hepatic Stellate Cell;Human;Image;improved;improved outcome;Incidence;Inflammation;intrahepatic;Laboratories;Length;Liver;Liver Cirrhosis;Liver diseases;liver function;liver inflammation;longitudinal database;Longitudinal Studies;Low-Molecular-Weight Heparin;machine learning prediction algorithm;Magnetic Resonance Elastography;Measures;meetings;Monitor;mortality;Natural History;neutrophil;novel;novel marker;novel therapeutics;Observational Study;Outcome;Pathogenicity;Patients;Phase;Phase III Clinical Trials;Placebos;Portal Hypertension;Portal Pressure;preclinical study;prediction algorithm;preservation;prevent;Prevention;Primary carcinoma of the liver cells;primary endpoint;prognostic;Prognostic Marker;prospective;radiological imaging;Randomized;randomized trial;Research;Research Personnel;Resolution;response;restoration;Risk;Safety;safety assessment;safety study;secondary endpoint;Simvastatin;success;supervised learning;telomere;Telomere Shortening;Testing;Therapeutic;therapeutic development;therapeutic target;Thrombosis;thrombotic;tool;Translational Research;translational study;Treatment Efficacy;trial design;Validation;Varicosity

PROJECT_TITLE: Liver Cirrhosis Network: Clinical Research Center - Mayo Clinic


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: AUSTIN

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: 8. PROJECT NARRATIVE Rural patients with end stage kidney disease (ESKD) suffer from disparities and limited access to home dialysis and kidney transplantation. Telehealth, recently brought to the forefront by the COVID-19 pandemic, represents a strategy to improve access to quality nephrology care and transplantation for rural patients with ESKD. The goal of this project is to understand the costs, benefits, and utilization of telehealth in the rural population with ESKD and to use this information to improve patient quality of life and access to care.

PI_NAMEs: ADLER, JOEL THOMAS (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Evaluating the role of telehealth in patients with end stage kidney disease (ESKD)

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Sleep Research;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Thalamic inflammation after traumatic brain injury is associated with a host of disabling and chronic deficits, including post-traumatic epilepsy and sleep disturbances, for which no approved treatments currently exist. This proposed work integrates molecular and electrophysiological techniques within neuroscience and immunology to probe how the overactivation of the classical complement system in the thalamus can set the stage for the development of long-term impairments. The ultimate goal of this research is to leverage and intercept immune pathology in the thalamus to guide the development of urgently-needed therapies for traumatic brain injury and its symptomology.

PI_NAMEs: NECULA, DEANNA  (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Acute;Affect;Affinity;Antibody Therapy;Behavior;Biological Markers;Brain;Cd68;cell type;Cells;Centers for Disease Control and Prevention (U.S.);Characteristics;Chronic;Classical Complement Pathway;Clinical Treatment;Collaborations;Complement;Complement 1q;Complement 4b;Complement Activation;complement system;Coupled;Data Science;Development;Disabling;Electroencephalography;Electrophysiology (science);Epidemic;Epilepsy;Epileptogenesis;Event;Evolution;Exhibits;experimental study;Feedback;Functional disorder;Generations;Genes;Genetic;Gliosis;Goals;Human;Immune;Immunohistochemistry;Immunology;Impaired cognition;Impairment;Individual;Inflammation;injured;Injury;Institution;Intercept;Ipsilateral;Laboratories;Long-Term Effects;Mediating;meetings;memory consolidation;Memory impairment;Mentorship;Microglia;Molecular;Molecular Profiling;motor impairment;motor recovery;mouse model;Mus;nanobodies;neocortical;neuroinflammation;Neurons;Neurosciences;non rapid eye movement;novel;Oligodendroglia;Outcome;Pathologic;Pathology;Persons;Phagocytes;Phagosomes;Play;Post-Traumatic Epilepsy;Prevalence;prevent;Proteins;Reporting;Research;Resources;Rodent;Role;Short-Term Memory;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;sleep regulation;sleep spindle;Sleeplessness;Source;statistics;symposium;Synapses;synaptic pruning;Tamoxifen;targeted treatment;TBI Patients;TBI treatment;Techniques;Testing;Thalamic structure;Therapeutic;Time;tool;Training;Traumatic Brain Injury;Work;World Health Organization

PROJECT_TITLE: The classical complement system in post-traumatic thalamic neuroinflammation


NIH_SPENDING_CATS: Assistive Technology;Autoimmune Disease;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Pediatric;Prevention

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: PROJECT NARRATIVE Automated Insulin Delivery systems have demonstrated superior glycemic outcomes in Type 1 Diabetes with increased time in target range, reduced hypoglycemia and improved hemoglobin A1c compared to other therapeutic options. The UVA Center for Diabetes Technology has been advancing algorithmic developments that underlie automated insulin delivery (AID) systems with the recent successful translation of a UVA-derived AID system that is now in clinical use in the U.S. Despite these advances, these hybrid closed-loop systems are still limited by requiring frequent user inputs, especially around meals. This proposal seeks to propel this field forward into fully automated closed-loop systems with meal anticipation in the context of accelerated insulin.

PI_NAMEs: BRETON, MARC D (contact);BROWN, SUE A

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Acceleration;Address;Adverse event;Algorithm Design;algorithm development;Algorithms;analog;Architecture;Artificial Pancreas;attenuation;Automation;basal insulin;Behavior;Blood Glucose;Bolus Infusion;burden of illness;Carbohydrates;Clinical;Clinical Research;Clinical Trials;commercialization;Computer Simulation;Data;Databases;design;Deterioration;Devices;Diabetes Mellitus;Disease Management;Dose;Eating;Ecosystem;Exposure to;FDA approved;Formulation;Glucose;glycemic control;Glycosylated hemoglobin A;Home;Hour;Hybrids;Hyperglycemia;Hypoglycemia;improved;in silico;indexing;Insulin;Insulin-Dependent Diabetes Mellitus;Kinetics;Laws;Legal patent;Length;Manuals;Measures;Medical Device;novel;Outcome;Outpatients;Participant;Patient Outcomes Assessments;Patients;Pattern;Pattern Recognition;Performance;Persons;Pilot Projects;predictive modeling;Randomized;Randomized, Controlled Trials;Research;Risk;Safety;satisfaction;Source;Speed;subcutaneous;success;System;Technology;Testing;Therapeutic;Time;tool;Translations;Work

PROJECT_TITLE: Advanced Artificial Pancreas Systems to Enable Fully Automated Glycemic Control in Type 1 Diabetes Mellitus

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Immunotherapy;Infectious Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BIRMINGHAM

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Chronic viral infections are a significant global public health concern as evidence by estimates that ~38, ~257, and ~71 million individuals world-wide are infected with human immunodeficiency virus, hepatitis B virus, and hepatitis C virus, respectively. The purpose of this proposal is to determine how the consortiums of specific immune cells that develop during chronic infections are configured and interconnected, as well as understand the immunological instructions that shape the composition of this pool. These studies are designed to provide new mechanistic information regarding why the host defense system is sometimes ineffective and how it can be structured to improve viral clearance.

PI_NAMEs: ZAJAC, ALLAN J (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Acceleration;acute infection;Adopted;Adoptive Transfer;anti-viral efficacy;Anti-viral Response;Attenuated;Biochemical;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Chronic;chronic infection;Chronic Phase;Containment;cytokine;Cytokine Signaling;defined contribution;design;Development;Effectiveness;exhaust;exhaustion;Frequencies;Goals;Growth;Hepatitis B Virus;Hepatitis C virus;HIV;Host Defense;Immune;immune checkpoint blockade;Immunologics;immunopathology;improved;Individual;Infection;Infection Control;innovation;insight;Instruction;Interleukin-2;Lymphocytic choriomeningitis virus;Maintenance;manufacture;Mediating;Modeling;permissiveness;Phase;Play;Population;Production;progenitor;Public Health;Publishing;Regulation;Resistance;response;restoration;Role;Series;Shapes;Signal Transduction;Source;Stat5 protein;Stem Cell Development;Structure;System;T-Cell Development;T-Lymphocyte;T-Lymphocyte Subsets;Testing;trait;Viral;Virus;Virus Diseases

PROJECT_TITLE: Resistance to T cell exhaustion

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Genetics;Immunization

ORG_CITY: RONKONKOMA

ORG_NAME: INGENIOUS TARGETING LABORATORY, INC.

ORG_STATE: NY

PHR: Narrative Antibodies, the pathogen-neutralizing proteins produced by the immune cells, are critical for the humoral immune response against bacteria and viruses and play a critical role in the immune responses to cancer. The unconventional single-chain antibodies from camelid species have unique target-binding properties and have greatly increased in vivo stability compared to conventional antibodies – properties that make them highly attractive for therapeutic and diagnostic applications. We propose to generate genetically-engineered mouse models that will allow in vivo production of partially humanized single-chain antibodies that resemble those from camel species, thus establishing a platform for the generation, optimization and testing of these unique antibodies for downstream therapeutic applications.

PI_NAMEs: KIRILOV, MILEN  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Affinity;Alpaca;Animal Model;animal resource;Animals;Antibodies;Antibody Affinity;antibody diagnostic;Antibody Formation;antibody libraries;Antibody Response;antigen binding;Antigens;Autoantigens;B-Cell Development;Bacteria;Basic Science;Benchmarking;Binding;Biological;Biological Products;Biological Testing;Biotechnology;Breeding;Businesses;Camels;Cells;Characteristics;Client;Clinical;clinical application;cohort;Complex;cost;Coupled;Custom;Development;Diagnostic;Disease;embryonic stem cell;Engineering;Enterobacter cloacae;environmental stressor;Epitopes;experimental study;Fab Immunoglobulins;flexibility;Future;Gene Bank;Gene Modified;Gene Targeting;Generations;Genes;Genetic;Genetic Engineering;genetic manipulation;Genetically Engineered Mouse;Goals;HIV;HIV Envelope Protein gp120;Homer 1;Housing;Human;hybrid antibody;Hybridomas;Hybrids;hydrophilicity;Immune;Immune response;Immunization;Immunize;immunogenicity;Immunoglobulins;improved;In Vitro;in vivo;in-vivo diagnostics;Individual;interest;Laboratories;Licensing;Light;Light-Chain Immunoglobulins;Link;Llama;Logistics;Malignant Neoplasms;Marketing;Medicine;Membrane;Modeling;mouse model;Mus;nanobodies;Natural Selections;Nature;neutralizing antibody;novel;null mutation;Outcome;pathogen;pathogenic microbe;Performance;Phage Display;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Phenotype;Play;preservation;Process;Production;Property;Proteins;Protocols documentation;Research;research and development;Resources;Role;SARS-CoV-2 spike protein;sensor;Services;Shark;Small Business Innovation Research Grant;standard of care;Targeted Research;Technology;Testing;Therapeutic;Therapeutic Agents;validation studies;Virus;Yeasts

PROJECT_TITLE: Research and Development to Establish a Small Animal Model as a Significant Resource of High-Value Single-Domain Antibodies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-D(10)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Intellectual and Developmental Disabilities (IDD);Major Depressive Disorder;Maternal Health;Mental Health;Mental Illness;Neurosciences;Pediatric;Pregnancy;Prevention;Serious Mental Illness;Women's Health Research

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Despite the high prevalence of women with prenatal depression, increasing treatment with SSRIs in conjunction with increasing prevalence of neurodevelopmental disorders, and evidence from animal models suggesting both prenatal depression and SSRIs may alter the normal processes of fetal brain development, our understanding of the long-term effects in humans remains poor. This longitudinal birth cohort study will evaluate the impact of prenatal depression and its treatment on 1) important clinical neurodevelopmental disorders in over 320,000 children up to eight years of age all born at Kaiser Permanente Northern California (KPNC) hospitals between 2013-2020 to women universally screened for prenatal depression and 2) less severe neurodevelopmental outcomes that do not meet the criteria for a clinical diagnoses in a subsample of 2,000 five-year-old children ascertained through parent interviews using standard and well-established instruments. Findings from this study will have significant public health and clinical implications by providing information that can be used immediately by pregnant women and clinicians making treatment decisions for prenatal depression.

PI_NAMEs: AVALOS, LYNDSAY AMMON (contact)

PROGRAM_OFFICER_NAME: TAYLOR-ZAPATA, PERDITA

PROJECT_TERMS: 5 year old;8 year old;Address;Age;Animal Model;antepartum depression;Area;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior Disorders;Behavioral;Birth;boys;Brain;Brain imaging;California;Categories;Child;Childhood;Clinical;clinical diagnosis;Code;Cognition Disorders;Cognitive;cohort;Cohort Studies;Communication;Communication impairment;Depression screen;design;Development;Diagnosis;Diagnostic and Statistical Manual of Mental Disorders;DSM-V;Early Intervention;Education;Electronic Health Record;emotional behavior;Epidemiology;epidemiology study;Fathers;fetal;Fetal Development;Fetus;girls;global developmental delay;Health;High Prevalence;Hospitals;Human;imaging study;Impairment;Infant;instrument;Intellectual functioning disability;Interview;Knowledge;Link;Literature;Long-Term Effects;Measures;Medical Records;Mental Depression;Methodology;Monitor;Mothers;Motor;motor disorder;motor impairment;Neurodevelopmental Disorder;Neurodevelopmental Impairment;offspring;Outcome;Parents;Patients;Performance;peripartum depression;Persons;Pharmacological Treatment;Population;Postpartum Depression;Postpartum Period;Pregnancy;Pregnant Women;prenatal;Prenatal care;prenatal testing;Prevalence;primary outcome;Problem Solving;Process;psychologic;Psychotherapy;Public Health;public health relevance;Questionnaires;Recording of previous events;recruit;Research;Risk;Risk Factors;Sampling;screening;screening program;secondary analysis;Selective Serotonin Reuptake Inhibitor;Services;Severities;sex;skills;social;Structure;Testing;Time;treatment effect;Woman;Women's cohort;Women's prevalence

PROJECT_TITLE: Comparing the Effects of Prenatal Depression and its Treatment on Developmental Outcomes of the Offspring

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Building Research Capacity at Institutions with Limited NIH Funding;Complementary and Integrative Health;Emerging Infectious Diseases;Infectious Diseases;Natural Products

ORG_CITY: YPSILANTI

ORG_DEPT: BIOLOGY

ORG_NAME: EASTERN MICHIGAN UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Infections caused by antibiotic-resistant microorganisms, sometimes referred to as “superbugs,” are becoming increasingly difficult to treat, making antimicrobial resistance a global health emergency that will seriously jeopardize progress in modern medicine. If we fail to act now and antibiotics lose their effectiveness, common medical interventions such as caesarean sections, cancer treatments, and hip replacements would become incredibly risky, and transplant medicine would be virtually impossible. The identification of new natural products that have antimicrobial activity still holds the best promise to curb the tide of antibiotic resistance, and this proposal outlines a new mixed-culture fermentation scheme that has the potential to rapidly accelerate the process of identifying novel classes of antibiotics that are effective against high-priority pathogens.

PI_NAMEs: CASPER, ANNE MARIE (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acceleration;Achievement;Agar;Antibiotic Resistance;Antibiotics;antimicrobial;Antimicrobial Effect;Antimicrobial Resistance;Area;Bacterial Antibiotic Resistance;Bacterial Genome;cancer therapy;Carbon;Cesarean section;Cessation of life;Chemicals;Chemotherapy-Oncologic Procedure;Coculture Techniques;Collection;Communities;Complex;Data;Disasters;drug candidate;drug discovery;Effectiveness;Exposure to;Face;Fermentation;Future;Gene Cluster;Genome;Genomics;global health emergency;hip replacement arthroplasty;Individual;Infection;Intervention;Lead;Medical;metabolomics;Metagenomics;Methods;Michigan;Microbe;microbial;microbial community;Microbial natural product;microorganism;Modern Medicine;Modernization;Molecular;natural antimicrobial;Natural product discovery;Natural Product Drug;Natural Products;Natural Products Chemistry;Nature;New Drug Approvals;novel;novel antibiotic class;Nutrient;Operative Surgical Procedures;Organism;Outcome;pathogen;Pathway Analysis;Physiological;Planet Earth;Play;Polysaccharides;priority pathogen;Procedures;Process;Production;programs;Property;Public Health;Reporting;Reproducibility;Research;scaffold;Scheme;screening;Self-Injurious Behavior;Soil;Source;Students;Superbug;Techniques;Technology;Testing;Therapeutic;Time;Training;transplantation medicine;undergraduate research experience;undergraduate student;United States;Universities;virtual;Work

PROJECT_TITLE: Redefining Fermentation Parameters in Natural Products Drug Discovery


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: PULLMAN

ORG_DEPT: PHARMACOLOGY

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Project Narrative  Mice have much longer telomeres than humans. While telomere shortening is a key mechanism of human aging, laboratory mice do not exhibit telomere-mediated aging. In this application, we plan to develop a genetically engineered mouse strain with humanized telomeres. Such mice should become an improved model for studying human aging and cancer.

PI_NAMEs: ZHU, JIYUE  (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Address;Adult;Affect;age-related disease;Aging;aging clocks;Alleles;Cancer Biology;Catalytic Domain;Cell Aging;Cell Differentiation process;Cell division;Cell Survival;Cells;Chromosomal Stability;Complex;Cross-Sectional Studies;Data;Defect;Development;Disease;Distal;DNA;Elements;Engineering;Epigenetic Process;Equilibrium;Event;Fibroblasts;Gene Expression Regulation;Generations;Genes;Genetic;Genetic study;Genetic Transcription;Genetically Engineered Mouse;Germ Lines;Goals;healthspan;Homeostasis;Human;human disease;human tissue;humanized mouse;hybrid gene;improved;in vivo;Knockout Mice;Laboratory mice;Laboratory Study;Length;life span;Link;Longitudinal Studies;Malignant Neoplasms;Mediating;Modeling;mouse development;Mouse Embryonic Stem Cells;mouse model;Mouse Strains;Mus;Organism;Pathogenesis;Process;Proteins;Regulation;Regulatory Element;Reporter Genes;Repression;Research;RNA;Somatic Cell;Study models;Telomerase;telomere;Telomere Shortening;TERT gene;Testing;Tissues;Trans-Activators;Transgenic Organisms;transmission process;Tumor Suppression;tumorigenic

PROJECT_TITLE: A mouse model with humanized telomere homeostasis

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lung;Lung Cancer;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: NARRATIVE Given the extremely high rates of cigarette smoking among people living with HIV (PLWH) and the many health risks associated with smoking, developing smoking cessation treatments for PLWH is a pressing public health need. The overall purpose of this study is to evaluate a new, fully automated smartphone-delivered smoking cessation intervention for PLWH. The intervention is designed to be more effective than human- delivered counseling in helping people quit smoking, while being far less expensive.

PI_NAMEs: VIDRINE, DAMON J. (contact)

PROGRAM_OFFICER_NAME: CICCOLO, JOSEPH THOMAS

PROJECT_TERMS: Abstinence;Address;Adopted;antiretroviral therapy;Behavioral;Biochemical;Cancer Center;Cardiovascular Diseases;Cellular Phone;cigarette smoking;Clinic;community organizations;Coronary heart disease;cost;Cost Analysis;cost effective;cost effectiveness;Counseling;Data;Data Management Resources;design;Development;Disease;Disease Progression;Disparity population;economic evaluation;efficacy evaluation;Enrollment;Evaluation;evidence base;experience;General Population;Goals;Health;Health Resources;Health system;HIV;HIV Seropositivity;HIV/AIDS;Human;improved;Individual;Intervention;Life Expectancy;Literature;Lung;Malignant Neoplasms;Mediating;Mediator;mHealth;mobile application;Mobile Health Application;Modernization;mortality;Motivation;Mouth Diseases;negative affect;nicotine replacement;non-smoker;Outcome;Participant;Persons;pharmacologic;Pilot Projects;Population;Prevalence;prevent;Proliferating;Public Health;public health priorities;Publishing;quitline;Randomized;randomized trial;Randomized, Controlled Trials;recruit;Research;resilience;Resource Sharing;Resources;Risk;safety net;Series;Site;Smoker;Smoking;smoking abstinence;smoking cessation;Smoking Cessation Intervention;smoking relapse;Smoking treatment;social disparities;social stigma;standard care;Stress;Symptom Burden;Telephone;Text;tobacco cessation intervention;tobacco control;Tobacco smoke;Treatment Efficacy;Treatment Failure;treatment group;treatment program;Work

PROJECT_TITLE: Randomized Trial of Automated Video-Assisted Smoking Treatment for People Living with HIV


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: DURHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARATIVE The goal of this research is to develop novel technologies that will facilitate and enhance the study of guanine exchange factors. Molecular probes developed in this proposal will allow the analysis of guanine exchange factors in their native cellular environment and provide information about the dynamics and spatial distribution of their activity. Since biological process controlled by guanine exchange factors are critical for normal cellular function and become dysregulated in various diseases, this research is relevant to the part of the NIH’s mission that pertains to protecting and improving health.

PI_NAMEs: AZOITEI, MIHAI LUCHIAN (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Affinity;Area;Binding;Binding Sites;Biological;Biological Models;Biological Process;biological systems;cell behavior;cell motility;Cell Physiology;Cells;Complex;Computer Models;Coupled;Cues;Darkness;design;DH Domain;Disease;Engineering;Ensure;Environment;Epitopes;experimental study;Face;Family;Frequencies;Goals;GTPase-Activating Proteins;Guanine;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate Phosphohydrolases;Health;Immune;immune activation;improved;in vivo;inhibitor;intersectin 1;irradiation;Kinetics;knock-down;Knock-out;Libraries;Light;live cell microscopy;Location;Methods;Mission;Molecular;Molecular Probes;Morphologic artifacts;nanobodies;new technology;novel;optogenetics;Outcome;overexpression;Phosphotransferases;Play;prevent;Proliferating;Protein Engineering;Proteins;Research;Resolution;rho;rho GTP-Binding Proteins;Role;scaffold;Scaffolding Protein;screening;Signal Pathway;Signal Transduction;Site;Spatial Distribution;spatiotemporal;Specificity;Structure;System;temporal measurement;Tertiary Protein Structure;Testing;Time;tool;United States National Institutes of Health;Work

PROJECT_TITLE: High throughput platform to engineer light-controlled inhibitors against guanine exchange factors of the Dbl family


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Congenital Structural Anomalies;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Pediatric;Primary Immunodeficiencies;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Project Narrative Using Bionano optical mapping technology we are taking a novel approach to understand the structure and organization of the 22q11.2 region deleted in 22q11.2DS and duplicated in 22q11.2 duplications, significant pediatric disorders. We will examine the prevalence and role of various inversion polymorphisms and copy number variants as risk factors for these and other genomic disorders of 22q11.2 in several populations (CEU, African and African Americans) including parent/ affected child trios of 22q11DS subjects. Further, we will determine whether allelic homologous recombination accounts for the extreme variability in the low copy repeats causing the genomic disorders of 22q11.2.

PI_NAMEs: EMANUEL, BEVERLY S (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: 22q;22q11;22q11.2;Affect;African;African American;African American population;Alleles;Automobile Driving;cat eye syndrome;caucasian American;Characteristics;Child;Childhood;Chromosome 22;Chromosome Deletion;Chromosomes;Classification;cohort;Complex;Copy Number Polymorphism;Data;DiGeorge Syndrome;Disease;Dissection;DNA;DNA Sequence;Ethnic Origin;Event;Family;Fostering;Frequencies;Gene Rearrangement;General Population;Generations;Genetic Polymorphism;Genetic Recombination;Genetic Structures;Genome;Genomic Segment;Genomics;Germ Lines;Goals;Haplotypes;homologous recombination;Hospitals;human disease;Human Genome;Individual;innovation;insight;Lead;Live Birth;Maps;Mediating;Meiosis;microdeletion;Molecular;nanochannel;neuropsychiatry;novel;novel strategies;offspring;Optics;Parents;Pathology;Patients;Phenotype;Play;Population;Positioning Attribute;Prevalence;proband;Recurrence;Risk Factors;Role;segregation;single molecule;Site;Structural defect;Structure;Suggestion;Syndrome;Technology;Testing;Variant;whole genome;Work

PROJECT_TITLE: Molecular Dissection of the 22q11.2 Deletion Syndrome

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Organ Transplantation;Prevention;Transplantation

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative: There is considerable uniformity in the rejection surveillance and prevention protocols used in heart transplant medicine, primarily due to a lack of precision diagnostic tools for assessing individual rejection risk. The inability to provide personalized immunosuppression and biopsy schedules that are tailored to individual risk exposes patients to serious and avoidable opportunistic infections, procedural injuries, and rejection events. This proposal aims to apply advanced informatics, computer-vision, and in-situ diagnostic methods to archived clinical data and biopsy tissues in order to develop a rejection risk-prediction model capable of improving precision in post-transplant care.

PI_NAMEs: PEYSTER, ELIOT  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Acute;advanced analytics;Algorithms;allograft rejection;Allografting;analysis pipeline;analytical method;analytical tool;archived data;Archives;Area;Assessment tool;Biopsy;career development;Caring;Clinical;Clinical Data;Clinical Informatics;cohort;Collection;Complex;Computer Analysis;Computer Vision Systems;Computing Methodologies;Data;data integration;data modeling;data resource;data streams;design;Diagnosis;Diagnostic;Diagnostic Procedure;Disease;Donor person;Electronic Health Record;electronic health record system;Event;Exclusion;experience;Exposure to;feature extraction;Funding;Future;Heart;heart allograft;Heart Transplantation;Hematoxylin and Eosin Staining Method;high risk;Histologic;histological specimens;Histology;Image Analysis;Immune;Immunodiagnostics;Immunofluorescence Immunologic;Immunologics;Immunosuppression;improved;In Situ;Individual;Inflammatory Infiltrate;Informatics;Injury;innovation;Institution;International;Investigation;Knowledge;Laboratories;Legal patent;Longevity;Lung Transplantation;Machine Learning;machine learning algorithm;machine learning method;meetings;Mentors;Modeling;Molecular;molecular modeling;Morphology;multimodality;Myocardial;myocardial injury;Nature;novel;Opportunistic Infections;Organ Transplantation;Pathology;Patients;Performance;personalized diagnostics;Pharmaceutical Preparations;pharmacologic;post-transplant;predictive modeling;predictive tools;Predictive Value;premature;prevent;Prevention;Prevention Protocols;Prevention strategy;Procedures;Process;prognostic;prospective;Protocols documentation;Publishing;quantitative imaging;Research;Research Personnel;Resources;Retrospective cohort;Risk;Risk Assessment;risk prediction;risk prediction model;risk stratification;Schedule;Slide;Societies;Solid;Spatial Distribution;Stains;standard of care;Standardization;surveillance strategy;Therapeutic immunosuppression;Time;tissue archive;Tissue Sample;Tissues;translational impact;translational potential;Translational Research;transplant centers;Transplant Recipients;Transplantation;Transplantation Immunology;transplantation medicine;treatment as usual;Weaning;Work

PROJECT_TITLE: Personalized Rejection Risk Assessment in Cardiac Transplantation

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: BOSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: TUFTS UNIVERSITY BOSTON

ORG_STATE: MA

PHR: Project Narrative Lyme disease places a substantial health (affecting >450,000 US citizens per year) and financial (costing Americans >$1 billion per year) burden on the United States. This project seeks to understand how the causal agent of Lyme disease, Borrelia burgdorferi, is able to survive, propagate, and spread in nature. Understanding the symbiotic relationship between B. burgdorferi and its natural rodent reservoir could reveal strategies to substantially reduce or even eradicate the pathogen from the wild, which would prevent spread of the bacteria to humans and the development of acute and/or chronic Lyme disease.

PI_NAMEs: BOURGEOIS, JEFFREY  (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Acute;Affect;American;Bacteria;Bacterial Genes;Biological Assay;Black-legged Tick;Borrelia;Borrelia burgdorferi;Canis familiaris;Cell Line;Cells;Characteristics;Chronic;cost;CRISPR/Cas technology;cytokine;Data;data integration;Data Set;Defect;Development;digital;Ecology;Elements;Enabling Factors;enzootic;experience;Experimental Designs;experimental study;feeding;Fibroblasts;follow-up;Foundations;Frequencies;Future;Gene Expression;Genes;Genetic;Genetic Screening;genome-wide;genomic tools;Glean;Goals;graduate school;Grant;Health;health goals;Histology;Histopathology;host-microbe interactions;House mice;Human;human pathogen;Immune response;Immunity;Immunologics;improved;In Vitro;in vivo;Inbreeding;Infection;Inflammation;insight;Institution;Kinetics;Knock-out;Laboratories;Lead;Left;Libraries;Longitudinal Studies;Lyme Disease;Macrophage;Microscopic;Molecular;Monitor;mouse model;Mus;mutant;Nature;novel;Paper;pathogen;Pathology;Pathway interactions;Patients;Peromyscus;post-doctoral training;Postdoctoral Fellow;prevent;programs;Public Health;Publications;Publishing;Reagent;Research;response;Rodent;Rodent Model;screening;Series;Side;Signal Pathway;skills;Skin;Symbiosis;Symptoms;Techniques;Testing;Ticks;Time;Tissues;tool;Training;training opportunity;transcriptome sequencing;transmission process;transposon sequencing;United States;vector tick;Work

PROJECT_TITLE: Identifying Determinants of Borrelia burgdorferi and Peromyscus leucopus symbiosis


ADMINISTERING_IC: EY

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative The goal of the proposed program is to support predoctoral students in vision research - to expand their understanding of current basic and clinical investigations on the eye and visual pathways, and to provide professional development in academic and science-allied careers. Areas of program strength include studies of higher-level influences on visual perception, of development and plasticity of visual circuitry, and of genetics and cell biology of retinal degeneration. This training is critical to the next generation of scientists who will tackle perturbations of vision at these levels.

PI_NAMEs: MASON, CAROL A. (contact);TROY, CAROL M

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Grant;Training;vision science

PROJECT_TITLE: Vision Sciences Training Grant


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Pediatric;Violence Research

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative Strong parental bonds are critical for human development and mental health. We have the opportunity to take advantage of highly conserved neuronal circuits in laboratory mice to better understand the molecular and neural foundation of the positive and negative regulation of parenting. Results from this study will provide a more thorough characterization of the negative regulation of parenting, specifically behaviors characterized as infant-directed aggression.

PI_NAMEs: SEDWICK, VICTORIA MARIE (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Ablation;Affinity;Aggressive behavior;Animals;Area;Axon;Behavior;Behavioral;biomarker validation;Brain;Brain region;candidate identification;candidate validation;Categories;Child Rearing;Copulation;Corticotropin-Releasing Hormone Receptors;CRF receptor type 2;Data;Exhibits;experience;experimental study;Female;Fiber;Foundations;Galanin;Genetic;Goals;Grooming;Hippocampus;Human Development;Immunoprecipitation;In Situ Hybridization;Infant;Infant Care;Infant Mortality;Infanticide;Injury;insight;Knowledge;Laboratory mice;male;Mammals;Maternal Behavior;Medial;Mental disorders;Mental Health;Molecular;Mus;neglect;neural;neural circuit;neurobiological mechanism;neuronal circuitry;Neurons;neuroregulation;novel;optogenetics;Outcome;Parents;Partner in relationship;Paternal Behavior;Phenotype;Phosphorylation;Photometry;Play;Population;Preoptic Areas;Presynaptic Terminals;pup;receptor;Regulation;Retrieval;Ribosomes;RNA Sequences;Role;sexual dimorphism;Signal Transduction;social;Social Behavior;Stereotyping;Synapses;Target Populations;targeted treatment;Testing;Transgenic Mice;urocortin;Viral;Work

PROJECT_TITLE: The role of the amygdalohippocampal area in infant-directed aggression


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Immune checkpoint blockade therapy has shown great promise, creating durable responses in a number of cancers, but the current drugs are expensive and have no survival benefit in brain cancer. We propose to find new targets for immunotherapy that will be effective for treating patients with glioblastoma –the most aggressive brain cancer. Specifically, we will determine how physical stresses in the tumor allow them to escape immunity, and then inhibit these pathways with strategies to improve outcomes and decrease toxicity in GBM patients.

PI_NAMEs: JAIN, RAKESH K.;MUNN, LANCE L. (contact)

PROGRAM_OFFICER_NAME: DUECK, HANNAH RUTH

PROJECT_TERMS: Affect;Animal Model;Animals;anti-cancer;Antibodies;Antigen-Presenting Cells;Biological Assay;Biomedical Engineering;Biotechnology;Blood Vessels;Brain Neoplasms;brain tissue;C57BL/6 Mouse;cancer cell;Cell Nucleus;Cell Proliferation;Cell Survival;Cells;Cephalic;checkpoint therapy;Clustered Regularly Interspaced Short Palindromic Repeats;Combined Modality Therapy;Confined Spaces;cranium;Cytoplasm;Data;Data Set;density;Diagnosis;efficacy evaluation;Environment;environmental stressor;epithelial to mesenchymal transition;Epithelium;Exposure to;G3BP1 gene;Genes;Genetic;genetic manipulation;Genetic Transcription;Glioblastoma;Goals;Growth;Human;Hypoxia;Immune;immune cell infiltrate;immune checkpoint;immune checkpoint blockade;immune checkpoint blockers;Immune response;Immune system;Immunity;Immunocompetent;Immunoglobulin G;Immunoprecipitation;Immunosuppression;Immunotherapy;Implant;improved outcome;In Vitro;in vivo;intravital microscopy;ITIM;Kinetics;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant Neoplasms;Measures;mechanical force;Mechanical Stress;Mechanics;Mediating;Mesenchymal;Messenger RNA;Methods;mouse model;mRNA Transcript Degradation;Mus;Nature;Nuclear Translocation;Organoids;Outcome;Pathway interactions;Patients;Perfusion;Pharmaceutical Preparations;pharmacologic;Phase;phase III trial;Phenotype;Primary Neoplasm;Prognosis;programmed cell death ligand 1;Proteins;Radio;Randomized;Receptor Inhibition;recruit;Regulation;Repression;Resistance;response;RNA;RNA Degradation;Sampling;Science;stemness;Stress;stress granule;T-Lymphocyte;Testing;The Cancer Genome Atlas;therapy resistant;Tissues;Toxic effect;transcriptome;transcriptome sequencing;tumor;tumor growth;Tumor Immunity;Variant;Western Blotting

PROJECT_TITLE: Targeting physical stress-driven mechanisms to overcome glioblastoma treatment resistance


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE This project will advance understanding of social dysfunction in schizophrenia, which is a core feature of the disorder that is associated with reduced quality of life and many negative health outcomes. By applying a novel research technique from non-clinical social neuroscience, this study will characterize specific relationships between patterns of brain activity and degree of social disconnection in schizophrenia. This new method is expected to yield a biomarker of social dysfunction in schizophrenia, which may be useful for identifying individuals at high risk of social disconnection, targeting treatments toward individuals most likely to benefit from them, or assessing outcomes in future clinical trials.

PI_NAMEs: PARKINSON, CAROLYN ;REAVIS, ERIC ANDREW (contact)

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Address;Affect;Area;Basic Science;Belief;Biological Markers;Brain;Brain region;cingulate cortex;Clinical Trials;Clip;Cognitive;Complex;Control Groups;Cues;Data;Development;Disease;experience;Face;Family;foot;forging;Friends;Functional Magnetic Resonance Imaging;functional MRI scan;Future;Health;high risk;improved;indexing;Individual;Individual Differences;Inferior;information processing;interest;Intervention;Life;Link;Lobule;Machine Learning;Major Mental Illness;Measures;Medial;member;mentalization;Methods;Modeling;neural;neuroimaging;Neurosciences Research;novel;novel marker;Outcome;Outcome Assessment;Parietal;Participant;Pattern;Perception;Persons;Prefrontal Cortex;Process;Psyche structure;Quality of life;Reaction;Research;Research Methodology;Research Technics;response;Risk;Schizophrenia;Series;social;social attachment;social contact;social deficits;Social Functioning;Social Interaction;social neuroscience;social relationships;Stimulus;Structure of middle temporal gyrus;Testing;Time;Translating;treatment trial

PROJECT_TITLE: Disrupted neural synchrony during naturalistic perception in schizophrenia: Toward a new biomarker of social dysfunction

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ORG_DEPT: CHEMISTRY

PHR: PROJECT NARRATIVE The ubiquitous presence of nitrogen atom in small-molecule probes and drugs highlights the significance of nitrogen-containing molecules in biomedical research and drug discovery. This project will develop new catalytic methods for regio- and stereoselective aminofunctionalization of alkenes, especially those involving C–N bond formation cascade reactions, to advance the synthesis and study of novel nitrogen-containing molecules. Such ability to prepare structurally diverse nitrogen-containing skeletons in the most rapid and efficient way possible is of the utmost importance, as is the ability to understand their biology, pharmacology and potential as new leads and tool compounds.

PI_NAMEs: WANG, QIU  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: New Methods for the Synthesis and Study of Bioactive Nitrogen-Containing Molecules

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


NIH_SPENDING_CATS: Neurosciences;Nutrition;Obesity

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE The prevalence of obesity in adults has grown tremendously over the past several decades, increasing the rates of type 2 diabetes, heart disease, and other obesity complications. To improve upon existing obesity treatments, we must understand the CNS neuronal populations that control feeding and energy balance. In this project, we seek to understand the regulation and mechanisms of action for a novel appetite-suppression population of hypothalamic neurons (LepRbGlp1R cells), which represent a potential site of therapeutic intervention in obesity.

PI_NAMEs: DUENSING, ALLISON  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Ablation;Adult;Appetite Stimulants;Body Weight;Brain;Brain Stem;Cardiovascular Diseases;Cell Nucleus;Cells;Central Nervous System;combat;Data;design;Desire for food;Detection;Diabetes Mellitus;diet-induced obesity;Eating;energy balance;Exhibits;Fasting;Feedback;feeding;Feeding behaviors;Food Energy;Gene Expression Regulation;GLP-I receptor;Glutamates;Health;Healthcare;Heart Diseases;hindbrain;Homeostasis;hormonal signals;Hypothalamic structure;improved;in vivo;Incidence;inhibitor;Institution;Laboratories;Leptin;leptin receptor;Modeling;molecular marker;Mus;Neurons;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;obese patients;Obesity;obesity treatment;Outcome;Peptides;Play;Population;Population Control;Prevalence;Pro-Opiomelanocortin;receptor expression;Receptor Signaling;Regulation;response;restraint;Role;Satiation;Signal Transduction;single nucleus RNA-sequencing;Site;Structure of dorsomedial hypothalamic nucleus;Structure of nucleus infundibularis hypothalami;System;Testing;Tetanus Toxin;Therapeutic Intervention;Weight Gain;Work

PROJECT_TITLE: Mechanisms of action for dorsomedial hypothalamic Lepr-Glp1r neurons that control feeding and energy balance


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Services;Kidney Disease;Patient Safety;Prevention

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative Currently, fragmented care after discharge from a hospital exists for patients who suffer severe acute kidney injury. The Cleveland COPE-AKI Clinical Center will be established to address how increasing the continuity of care provided after discharge can reduce healthcare costs but improve patient outcomes.

PI_NAMEs: DEMIRJIAN, SEVAG ;HUML, ANNE MARIE;POGGIO, EMILIO DANIEL (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;Albuminuria;Ambulatory Care;Angiotensins;arm;barrier to care;biobank;Blood;Blood Pressure;blood pressure control;Blood Vessels;care coordination;care fragmentation;Caring;Chronic Kidney Failure;Classification;Clinic;Clinical;clinical center;Clinical Trials;Complication;Continuity of Patient Care;cost;cost effectiveness;Creatinine;Critical Illness;Data;design;Development;Diagnosis;Dialysis procedure;DNA;economic outcome;Economics;Emergency Care;Emergency department visit;empowerment;End stage renal failure;Event;Exhibits;experience;Feces;frailty;Future;Glomerular Filtration Rate;Guidelines;Health Care Costs;health care service utilization;health management;Health Status;Healthcare;Heart failure;high risk;Hospitalization;Hospitals;improved;innovation;Internal Medicine;Intervention;Intervention Studies;Investigation;Kidney;Kidney Diseases;Link;Lung Diseases;Managed Care;Measurement;Modeling;Monitor;Morbidity - disease rate;mortality;mortality risk;Nephrology;Nurses;Operative Surgical Procedures;Outcome;Outpatients;Participant;participant enrollment;Pathogenicity;Pathway interactions;Patient Monitoring;patient navigation;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Periodicals;Personal Satisfaction;personalized care;Pharmacologic Substance;Policies;Population;Preparation;prevent;process improvement;Proteinuria;Protocols documentation;psychological distress;Quality of life;Randomized;readmission rates;remote patient monitoring;Renal function;Renin;Renin-Angiotensin System;Reporting;Research;Risk;Risk Factors;Sampling;screening;Serum;Severities;Site;standard of care;Structure;Supervision;Survivors;System;Testing;Therapeutic Intervention;Time;time interval;treatment as usual;trial design;United States National Institutes of Health;Urine;virtual;Visit;Weight;Work

PROJECT_TITLE: Cleveland COPE-AKI Clinical Center


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Infectious Diseases;Mental Health;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE Mobile populations experience higher rates of HIV acquisition and inadequate access to health services in sub- Saharan Africa, yet HIV programs are still ill-equipped to meet the needs of specific mobile groups. Since population movement also facilitates the spatial spread of the virus, HIV programs working towards elimination must target and tailor services to mobile populations at the greatest risk of HIV acquisition and onward transmission. This study will characterize distinct forms of mobility in south-central Uganda, an area with substantial population movement, and relate each to critical gaps in the HIV response.

PI_NAMEs: KHALIFA, ALEYA R (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Adult;Africa South of the Sahara;African;Age;age related;aged;Area;Avidity;barrier to care;Biological Assay;Biological Markers;Caliber;career;Case/Control Studies;Categories;Climate;cohort;Cohort Studies;Communicable Diseases;Communities;community transmission;Country;Data;Data Analyses;Dedications;Dimensions;Economics;Epidemic;Epidemiologic Methods;Exhibits;experience;Face;follow-up;Frequencies;Future;Gender;Goals;Health;Health Services Accessibility;HIV;HIV Infections;HIV risk;HIV Seronegativity;Home;Household;Human;Human immunodeficiency virus test;improved;Incidence;Individual;Institution;Intervention;Investigation;Knowledge;Learning;Link;Location;longitudinal analysis;Longitudinal cohort;Longitudinal Studies;Longitudinal Surveys;Measures;Mentorship;Methods;mHealth;migration;Motivation;Movement;National Institute of Mental Health;Odds Ratio;Outcome;Parents;Participant;Partner Notification;Pathway Analysis;Pattern;Persons;Politics;poor health outcome;Population;population based;population health;population movement;Population Research;Population Study;pre-exposure prophylaxis;Prevalence;Prevention;prevention service;programs;Questionnaires;Religion;Research;research data dissemination;Research Personnel;Resources;response;Risk;Sampling;Selection Bias;self testing;service delivery;Service delivery model;Services;Sexual Partners;skills;social;social epidemiology;spatial epidemiology;Subgroup;Survey Methodology;Surveys;Testing;Training;transmission process;Travel;treatment adherence;Treatment outcome;Uganda;Universities;Unsafe Sex;Viral Load result;Virus;Visit;wasting;Work

PROJECT_TITLE: Applying a multidimensional measure of human mobility to understand drivers of HIV incidence in Rakai, Uganda


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Narrative Muscular dystrophies and myopathies, as well as muscle dysfunction due to aging and injury remain important public health issues. This program will train predoctoral students and postdoctoral fellows in an interdisciplinary approach to the study of muscle and muscle disease at the molecular, cellular, tissue, organ and whole animal levels. Our trainees will provide an important future resource in the search for remedies and eventual cures for a variety of primary and secondary muscle diseases.

PI_NAMEs: KONTROGIANNI-KONSTANTOPOULOS, AIKATERINI  (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Biology;Muscle;Training Programs

PROJECT_TITLE: Interdisciplinary Training Program in Muscle Biology


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: MOSCOW

ORG_NAME: UNIVERSITY OF IDAHO

ORG_STATE: ID

PHR: Human health is determined by interactions of complex biological systems at multiple scales, from the ecological to the biophysical; these are layered with spatial and temporal variation. To decipher these systems requires predictive modeling, coupled with strong empirical work, to be guided by and to feed the models. The Center for Modeling Complex Interactions generates model-based biomedical research and connects people who might otherwise never interact, which enhances the strong interdisciplinary culture of the University of Idaho.

PI_NAMEs: WICHMAN, HOLLY A (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: Acceleration;Address;Area;Biological;biological systems;Biomedical Research;Biophysics;Body System;Businesses;Centers of Research Excellence;Collaborations;Communication;Communities;Complex;complex biological systems;Computer Models;Coupled;Data;Development;Disease;Ensure;experience;Experimental Designs;Faculty;faculty support;Feedback;Formulation;Fostering;Foundations;Funding;Funding Agency;Future;Generations;Goals;Grant;Growth;Health;Holly;Home;Human;Human Resources;Idaho;improved;Incubators;Individual;Infrastructure;innovation;insight;Institution;interdisciplinary approach;Interdisciplinary Study;Language;Machine Learning;mathematical methods;member;Modeling;next generation;novel strategies;Outcome;Persons;Phase;Physical environment;physical model;Pilot Projects;Play;Population;Postdoctoral Fellow;predictive modeling;Preparation;Privatization;Progress Reports;Property;Reproducibility;Research;Research Institute;Research Project Grants;Research Support;Schedule;Scientist;Structure;Students;success;System;Testing;three-dimensional modeling;Time;Training;Uncertainty;undergraduate student;Universities;Variant;Work;working group


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Advisory Committees;Area;Biomedical Research;career development;college;Communication;Communities;Complex;data literacy;early-career faculty;Educational workshop;Environment;Evaluation;experience;Faculty;faculty mentor;Feedback;Funding;Goals;Grooming;Holly;improved;Individual;meetings;member;Mentors;Modeling;Monitor;next generation;outreach;Participant;peer;Phase;Pilot Projects;Postdoctoral Fellow;Principal Investigator;Productivity;programs;Recording of previous events;recruit;Reporting;Research;Research Personnel;Research Project Grants;Role;Running;searchable database;Series;success;Surveys;System;Training;Universities;web site;working group

PROJECT_TITLE: Administrative Core


PI_NAMEs: MILLER, CRAIG R (contact)

PROJECT_TITLE: Modeling Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Gene Therapy;Genetics;Human Genome;Immunotherapy

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE CRISPR-based T cell engineering offers unprecedented opportunities to reprogram cellular functions in order to develop advanced cell therapies that improve cancer outcomes and expand patient access. This project will implement a diverse CRISPR toolset for genome, epigenome, and transcriptome modification to understand critical parameters affecting primary human T cell engineering outcomes, and will incorporate these tools within a multiplexed and clinically-compatible T cell manufacturing pipeline to develop safer and more effective cancer therapies.

PI_NAMEs: SHY, BRIAN R (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Achievement;Adenosine;Affect;Allogenic;Award;base editing;base editor;California;Cancer Patient;cancer therapy;CAR T cell therapy;career;career development;CD47 gene;Cell Physiology;Cell Reprogramming;Cell Therapy;cellular engineering;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clinical Engineering;clinical implementation;clinical training;Clinical Trials Design;Clustered Regularly Interspaced Short Palindromic Repeats;cost;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;curative treatments;Cytosine;Development;DNA;DNA Repair Pathway;Educational workshop;engineered T cells;Engineering;Epigenetic Process;epigenome;FDA approved;Fostering;Funding;Genes;Genetic;genetic element;Genome;Goals;Good Manufacturing Process;Grant;Hematologic Neoplasms;Human;human disease;Hybrids;Immune;Immunophenotyping;improved;Knock-in;Knock-out;Knowledge;Laboratories;large datasets;Lead;Libraries;Malignant Neoplasms;manufacture;manufacturing process;Mediating;Mediator;meetings;Mentors;Methods;Modality;Modification;Multiple Myeloma;next generation;next generation sequencing;Nonhomologous DNA End Joining;novel;Nuclear;Nucleotides;Outcome;Pathogenicity;Pathway interactions;Patients;Physicians;Physiological;preclinical development;preclinical study;Process;Production;programs;Regulatory Element;repaired;Research;Research Activity;Research Personnel;Research Proposals;response;Role;Safety;San Francisco;Scientist;Single-Stranded DNA;Site;skills;small molecule;small molecule inhibitor;Source;standard of care;symposium;T cell therapy;T-Cell Receptor;T-Lymphocyte;Technology;Therapeutic;tool;Toxic effect;Training;transcriptome;transfusion medicine;Treatment outcome;Universities;Viral;Viral Vector;Virus;Writing

PROJECT_TITLE: Non-viral genome, epigenome, and transcriptome engineering for clinical CAR-T cell manufacturing

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: SANTA CRUZ

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: Project Narrative Our proposal will build the next generation of UCSC Xena to support interactive online visualization and analysis of very large-scale, multi-omics single-cell and bulk tumor data, and integrate these high-performance visualizations with NCI Cloud Resources. These enhancements will make comprehensive cancer genomics reference datasets, including maps of all human cells and cellular mappings of cancers, more accessible to a larger group of biomedical researchers. Our proposed work will also help individual researchers to securely view their own data and analysis results from a cloud-based research environment.

PI_NAMEs: HAUSSLER, DAVID H;ZHU, JINGCHUN  (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Acceleration;analytical tool;anti-cancer research;Architecture;Atlas of Cancer Mortality in the United States;Biology;Brain Neoplasms;cancer genomics;cancer stem cell;Cells;Child;Childhood;cloud based;Collaborations;Communities;Complement;Complex;Computers;Data;data access;Data Analyses;Data Collection;Data Commons;data harmonization;data integration;data resource;data science infrastructure;Data Set;data visualization;Databases;design;Development;drug development;Drug resistance;Education;Educational process of instructing;Engineering;Environment;Galaxy;Genome;genome browser;genome resource;genomic profiling;genomic signature;Genotype-Tissue Expression Project;Growth;Human;Human BioMolecular Atlas Program;Human Genome;improved;indexing;Individual;Ingestion;insight;interactive visualization;International;Internet;Joints;large datasets;Link;Malignant Childhood Neoplasm;Maps;Medicine;Methodology;Modeling;Multiomic Data;multiple omics;next generation;novel therapeutics;Organoids;outreach;patient derived xenograft model;Pediatric Neoplasm;Performance;Population;pre-clinical;Pre-Clinical Model;Privatization;prototype;Publications;Research;Research Personnel;Resources;routine practice;Sampling;scale up;Secure;single cell genomics;Standardization;therapeutic evaluation;Tissues;tool;Training;transcriptome sequencing;tumor;Update;user centered design;virtual;Visualization;Visualization software;Work

PROJECT_TITLE: Enhance UCSC Xena: extend interactive visualization to ultra-large-scale multi-omics data and integrate with analysis resources


ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: NARRATIVE Inflammation and metabolism are tightly linked processes with consequences for human diseases such as obesity and Type 2 diabetes. Despite the identification of many avenues of molecular cross-talk between them, little is known about how key genes are regulated at the nexus of inflammation and metabolic function, or even which genes are most important. We have identified the transcription factor IRF3 as a critical mediator of inflammation in fat and liver; here we propose to identify the mechanisms by which IRF3 exerts its detrimental effects on metabolic health.

PI_NAMEs: ROSEN, EVAN D (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Ablation;Accounting;Address;Adipocytes;Adipose tissue;Adverse effects;Affect;Antisense Oligonucleotides;Area;blood glucose regulation;Body Weight;Brown Fat;cell type;Cellular biology;Chronic;Coupled;cytokine;Data;endophenotype;Environment;enzyme activity;epigenomic profiling;epigenomics;experimental study;Family;Fatty acid glycerol esters;Fatty Liver;feeding;Functional disorder;Funding;Gene Expression;Gene Expression Profiling;Genes;genetic manipulation;Genetic Transcription;Genomics;Glycolysis;Goals;Health;Hepatocyte;human disease;Immune;immune cell infiltrate;Immune signaling;Immunity;Impairment;improved;in vivo;Inflammation;Inflammation Mediators;Inflammatory Response;Insulin;Insulin Resistance;insulin sensitivity;insulin signaling;Interferons;IRF3 gene;ISG15 gene;Knowledge;Kupffer Cells;Laboratories;Learning;Link;Liver;Lysine;Macrophage;Mediating;Mediator;member;Metabolic;Metabolic Control;Metabolic dysfunction;Metabolism;Molecular;Mus;NF-kappa B;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Overnutrition;Pathway interactions;Peripheral;Phenocopy;Phenotype;Physiological;Play;Positioning Attribute;Process;programs;Proteins;Publishing;Reagent;Repression;Research Personnel;Resistance;Resolution;response;Role;sample fixation;Signal Transduction;systemic inflammatory response;Testing;Therapeutic;Therapeutic Intervention;Thermogenesis;Tissues;tool;transcription factor;Transcriptional Regulation;Transgenes;Ubiquitin;ubiquitin-protein ligase;Weight Gain;Work

PROJECT_TITLE: Role of IRF3 in Energy and Glucose Homeostasis

STUDY_SECTION: IPOD

STUDY_SECTION_NAME: Integrative Physiology of Obesity and Diabetes Study Section[IPOD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Fragile X Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Auditory sensory anomalies and speech and language impairments are common and impairing in individuals with Fragile X Syndrome (FXS), but the biological basis of these impairments and their developmental trajectory in the infant and toddler years has not been systematically investigated. This limits mechanistic understanding of these features and development of brain- based biomarkers for treatment development in early life when interventions may be most effective. This project combines multimodal neural measures (EEG/fNIRS), speech and language assessment, and audiological measures to address this gap by: 1) characterizing auditory hypersensitivity at the neural level and its relation to speech and language functioning in preschoolers with FXS, and 2) tracking the emergence and developmental progression of neural substrates of auditory, speech and language difficulties in the infant years, with the longer term goal of informing and improving early interventions.

PI_NAMEs: SMITH, ELIZABETH GAYLE (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: 10 year old;Address;Adolescent;Adult;Age;Age Months;analytical method;Anatomy;Animal Model;Area;Audiology;Auditory;Auditory Perception;Auditory system;autism spectrum disorder;Behavioral;behavioral phenotyping;Biological;Biological Markers;Brain;brain based;Brain imaging;career;career development;Caring;Child;Clinical;Communication impairment;Control Groups;Data;Detection;Development;Development Plans;Diagnosis;Disease;early detection biomarkers;Early Intervention;Electroencephalography;Electrophysiology (science);Ethics;Etiology;Evaluation;experience;Fragile X Syndrome;functional near infrared spectroscopy;Genetic;Goals;Hearing;Hearing Tests;hemodynamics;Heritability;high risk;Home environment;human model;Hypersensitivity;Impairment;improved;indexing;Individual;infancy;Infant;Intellectual functioning disability;Intervention;K-Series Research Career Programs;Language;Language Delays;Language Development;language impairment;Learning;Life;life span;Linguistics;Link;Longitudinal Studies;Measurement;Measures;Mediator;mental age;Mentors;Mentorship;Methods;Modeling;multimodality;Nature;neural;Neurodevelopmental Disorder;neuroimaging;neuromechanism;neurophysiology;Outcome;Pattern;Phase;Phenotype;post-doctoral training;Premature Birth;Program Development;programs;Recording of previous events;Research;Research Ethics;Research Methodology;Research Personnel;Resources;response;Risk;Science;Scientist;Sensory;Series;Severities;signal processing;skills;sound;Sound Localization;Specificity;Speech;Speech Delay;Speech Development;Statistical Methods;success;Techniques;Testing;therapy development;Time;Toddler;tool;Training;Treatment Effectiveness;treatment response;United States National Institutes of Health;Visit

PROJECT_TITLE: Tracking early emergence of sound perception impairments in FXS with multimodal fNIRS/EEG


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Neurosciences

PI_NAMEs: PATEL, JAGDISH SURESH  (contact)

PROJECT_TERMS: 3-Dimensional;Amino Acid Sequence;Amino Acids;Chemicals;chromophore;Color Visions;Complex;computational pipelines;Data;Data Set;Development;Disease;disease-causing mutation;Electronics;Engineering;Foundations;Genome;Goals;Homology Modeling;Human;Impairment;improved;Lead;Machine Learning;machine learning pipeline;Modeling;Molecular;Molecular Conformation;molecular dynamics;molecular mechanics;molecular modeling;Mutation;novel;novel strategies;Opsin;optogenetics;Pathologic;phenome;Phototransduction;Pigments;Population;predictive modeling;Process;Property;Proteins;Quantum Mechanics;Research;Retinal Cone;Retinal Pigments;Running;Series;simulation;Statistical Models;Structure;Structure-Activity Relationship;targeted treatment;Testing;Therapeutic;Vertebrate Photoreceptors;Vision;Visual

PROJECT_TITLE: Sequence-structure-function relationships in human visual photopigments


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Microbiome

PI_NAMEs: VAN LEUVEN, JAMES  (contact)

PROJECT_TERMS: Adopted;Animal Experiments;Animal Model;Animals;Apis;Bacteria;bacterial community;bacterial resistance;Bacteriophages;Biological Models;Coculture Techniques;Communities;Complex;Development;Disease;dynamical evolution;Ecology;Environment;Evolution;experimental study;Genetic Materials;Genome;Goals;Growth;Health;Immune system;Immunologic Stimulation;Infection;Knowledge;Liquid substance;mathematical model;Measures;member;Microbe;microbial;microbial community;microbial composition;microbiome;microorganism interaction;Modeling;outcome prediction;Predatory Behavior;Process;Property;Research;Resistance;Role;Shapes;System;Testing;Time;Virulence;Virus;Work

PROJECT_TITLE: Identifying phage-bacteria interactions using a multispecies model


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Colorectal Cancer;Digestive Diseases;Liver Disease;Nutrition;Prevention

ORG_DEPT: NUTRITION

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE We propose to conduct a comprehensive study on the relationship between hepatic fat infiltration and risk of liver metastases. This study will help to establish a safe and cost-efficient prognostic biomarker for stage I-III CRC patients, and provide the scientific foundation for future exploration into behavioral and pharmacological interventions, specifically targeting high hepatic fat infiltration. Considering the alarming rise in prevalence of non-alcoholic fatty liver disease in the U.S. and globally, these interventions may help to reduce morbidity and mortality in a substantial number of stage I-III CRC patients.

PI_NAMEs: GIOVANNUCCI, EDWARD  (contact)

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: Adhesions;Affect;aged;attenuation;Behavior assessment;Behavioral;Biological Markers;Body Composition;California;cancer diagnosis;Cancer Survivor;Cells;Central obesity;Clinical;Clinical Data;cohort;colon cancer patients;Colorectal Cancer;colorectal cancer metastasis;colorectal cancer progression;comorbidity;cost;cost efficient;Data;Data Set;design;Development;Diabetes Mellitus;Diagnosis;Disease;Distant Metastasis;Dose;Dyslipidemias;Etiology;Excision;Fatty acid glycerol esters;Foundations;Future;future implementation;Goals;Guidelines;Hepatic;high risk;Image;improved;inclusion criteria;Individual;Infiltration;Inflammatory;innovation;Intervention;Link;Liver;Liver Cirrhosis;liver development;Liver diseases;Machine Learning;Manuals;Measurement;Measures;Mediating;Metabolic;Metabolic syndrome;Metastatic Neoplasm to the Liver;Methods;Micrometastasis;MicroRNAs;Morbidity - disease rate;mortality;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplasm registry;non-alcoholic fatty liver disease;non-diabetic;novel;Operative Surgical Procedures;Pathway interactions;Patients;Pattern;pharmacologic;Pharmacologic Substance;physical inactivity;Plasma;Population;Predisposition;Prevalence;Primary carcinoma of the liver cells;Primary Malignant Neoplasm of Liver;Prognosis;Prognostic Factor;Prognostic Marker;radiologist;Recurrence;Relapse;response;Risk;Risk Factors;risk stratification;Role;sarcopenia;Scanning;Signal Pathway;Site;Skeletal Muscle;sociodemographics;Soil;Spleen;Standardization;subcutaneous;Subgroup;Testing;Thinness;Time;tool;tumor-immune system interactions;Visceral fat;X-Ray Computed Tomography

PROJECT_TITLE: Association between pre-diagnosis hepatic fat infiltration and risk of liver metastasis and mortality in a large cohort of stage I-III colorectal cancer survivors

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Hematology;Human Genome;Precision Medicine;Rare Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Despite numerous advances in the treatment of multiple myeloma, it remains an incurable disease, and novel treatments are acutely needed. Bcl-2 family inhibitors such as venetoclax represent a promising new class of drugs, however the mechanisms underlying intrinsic sensitivity or resistance to these drugs remain poorly understood. We have identified a unique B cell-like signature in multiple myeloma and will investigate how this signature affects response to Bcl-2 inhibitors and whether it can be used as a biomarker for future precision medicine driven trials.

PI_NAMEs: GUPTA, VIKAS ANAND (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Acute;Affect;Apoptosis;Apoptotic;ATAC-seq;B lymphoid malignancy;B-Lymphocytes;BCL2 gene;BCL2L1 gene;Binding;Binding Sites;Bioinformatics;Biological Markers;Biology;biomarker driven;biomarker identification;Bortezomib;career;Cell Line;Cell surface;Cell Survival;Cells;Cellular biology;Cessation of life;Characteristics;Chromatin;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR screen;Cytometry;Dependence;Development;differential expression;Disease;Drug resistance;epigenomics;Family;Flow Cytometry;Foundations;Funding;Future;Gene Expression Profile;Genes;Genetic study;Genetic Transcription;Genomics;Goals;Grant;Heterogeneity;immune modulating agents;improved;In Vitro;inhibitor;K-Series Research Career Programs;knock-down;Laboratories;Leadership;Machine Learning;Malignant Neoplasms;Manuscripts;MCL1 gene;Measures;Mediating;Mentors;Molecular;multidisciplinary;Multiple Myeloma;New Agents;novel;novel drug class;novel marker;overexpression;Pathogenesis;Patient Selection;patient subsets;Patient-Focused Outcomes;Patients;Pattern;Pharmaceutical Preparations;Phenotype;Physicians;Plasma Cells;precision medicine;Precision medicine trial;predicting response;predictive signature;pro-apoptotic protein;programs;Proteasome Inhibitor;Protein Family;Proteins;Regulation;Research Technics;Resistance;resistance mechanism;response;Role;Sampling;Scientist;Signal Transduction;skills;Source;standard of care;Testing;Therapeutic;therapy resistant;Training;transcription factor;Transcription Factor AP-1;transcriptome sequencing;Translating;treatment response;tumor;United States National Institutes of Health;Work;Writing

PROJECT_TITLE: Regulation of Bcl-2 dependence in multiple myeloma


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Cardiovascular;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Disability Research;Liver Disease;Patient Safety;Precision Medicine;Prevention;Rare Diseases;Substance Misuse

PHR: Project Narrative Advanced liver scarring, also known as cirrhosis, is increasing in incidence in the US and is associated with several deadly complications, however we lack ways to predict and prevent these complications. As part of a study including multiple sites around the United States, we will enroll patients with cirrhosis and develop risk models to predict cirrhosis-associated outcomes. We will also perform a clinical trial to determine the impact of statins on the natural history of cirrhosis and its associated complications.

PI_NAMEs: PARIKH, NEEHAR DILIP;TAPPER, ELLIOT  (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Address;Adverse event;Alcohol abuse;alcohol use disorder;Alcoholic Liver Diseases;American;associated symptom;Attention;Biological Markers;Blood;Calibration;cardiovascular risk factor;Cardiovascular system;Caregivers;Caring;Cessation of life;Child;Cicatrix;Cirrhosis;Clinical;clinical practice;Clinical Research;clinical risk;Clinical Trials;cohort;Collaborations;Collection;Compensation;Complex;Complication;Computerized Medical Record;Data;Data Collection;Data Coordinating Center;debilitating symptom;Development;Dimensions;disability;Discrimination;Disease;Disease Progression;Distress;Dyslipidemias;effective therapy;elastography;electronic medical record tool;end stage liver disease;Epidemiology;epidemiology study;Etiology;Event;Exclusion Criteria;falls;Fibrosis;frailty;Funding;Health Care Costs;Heart Diseases;Hepatic;Hepatic Encephalopathy;Hepatology;High Prevalence;high risk;hospital readmission;Hypertension;improved;Incidence;inclusion criteria;indexing;Individual;innovative technologies;Laboratories;Link;Lipids;Lived experience;Liver;Liver Fibrosis;liver transplantation;Longitudinal cohort;Measurement;Measures;Medical;Medicare;Mental Depression;Metabolic;Methods;Michigan;Modeling;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;novel;Observational Study;Outcome;outcome prediction;participant enrollment;Pathway interactions;Patient Outcomes Assessments;patient population;Patient risk;Patients;Placebo Control;Portal Hypertension;Positioning Attribute;predictive modeling;Prevalence;prevent;Prevention therapy;Primary carcinoma of the liver cells;primary outcome;prognostic;prognostic index;prognostic model;prognostic value;prognostication;programs;prospective;Provider;Quality of life;Randomized;randomized placebo controlled trial;recruit;Research Infrastructure;Resources;response;Risk;risk prediction;Risk Reduction;risk stratification;Role;secondary outcome;Site;Stratification;Symptoms;Systemic blood pressure;Therapy trial;tool;trial design;Twin Multiple Birth;United States;Universities;Vasodilation;Viral;Woman;Work

PROJECT_TITLE: Statin Therapy for patients with compensated Cirrhosis


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Autoimmune Disease;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Multiple Sclerosis;Neurodegenerative;Neurosciences;Nutrition;Physical Activity;Prevention;Rehabilitation;Social Determinants of Health

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Results from this project will inform clinical recommendations for persons with MS regarding their cognitive impairment (i.e., “prescribing” health-related behaviors). It will also provide preliminary data to design a lifestyle intervention that targets multiple health-related behaviors, in order to improve cognition. Such an intervention will significantly improve the lives of persons with MS as well as other clinical populations with cognitive impairment.

PI_NAMEs: CHEN, MICHELLE H (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Accounting;Adherence;Affect;Aging;Behavior;Behavioral;Biometry;Blood Vessels;career;Clinical;Clinical Investigator;Clinical Trials Design;Cognition;Cognitive;cognitive change;cognitive rehabilitation;cognitive testing;cognitive training;cohort;Community Participation;comorbidity;Conduct Clinical Trials;Data;Dementia;design;Diet;Disease;Double-Blind Method;Epidemiology;Equipment and supply inventories;Exercise;follow-up;Funding;Goals;good diet;Grant;Health;Health behavior;health belief;health care availability;Impaired cognition;improved;Individual;instrumental activity of daily living;interest;Intervention;Interview;Investigation;Laboratories;Learning;Life Style;lifestyle factors;lifestyle intervention;Link;Literature;Long-Term Effects;Longitudinal, observational study;Manuscripts;Measures;Medical center;Mentors;Mentorship;Mission;modifiable risk;Monitor;multidisciplinary;Multiple Sclerosis;multiple sclerosis patient;neuroimaging marker;neuroprotection;Neuropsychology;older adult;Participant;Patient Self-Report;Performance;Persons;Pharmaceutical Preparations;pharmacologic;Population;population based;prospective;psychosocial;Qualitative Research;Randomized, Controlled Trials;Recommendation;rehabilitation research;Rehabilitation therapy;Research;Research Design;Research Personnel;Risk;Risk Factors;Role;Secondary Prevention;skill acquisition;skills;Sleep;Smoking;social;social health determinants;Social support;standard care;Standardization;Structure;substance use;Surveys;symptom management;Symptoms;systematic review;Techniques;Time;Training;United States National Institutes of Health;Work;Writing

PROJECT_TITLE: Longitudinal Impact of Health and Lifestyle Behaviors on Cognition in Individuals with Multiple Sclerosis

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Biobehavioral and Behavioral Sciences Study Section[CHHD-H]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Mental Health;Neurodegenerative;Neurosciences;Sleep Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Persons in the early stage of Alzheimer's disease (termed Mild Cognitive Impairment [MCI]) often have problems with sleep, and there is evidence that poor sleep may contribute to cognitive decline. Trazodone is an FDA-approved medication widely used off-label to improve sleep and has a favorable side effect profile in older adults. We propose a randomized, controlled crossover trial comparing the effect of 1 month trazodone vs. placebo in 100 older adults with MCI and sleep complaints, and hypothesize that trazodone will not only improve sleep but improve a type of memory (pattern separation) and improve hippocampal function (assessed by functional MRI).

PI_NAMEs: GREENBERG, BARRY DAVID (contact);ROSENBERG, PAUL B

PROGRAM_OFFICER_NAME: CLARKE, AKANNI YAO

PROJECT_TERMS: actigraphy;Acute;Affect;Alleles;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer’s disease biomarker;amnestic mild cognitive impairment;Amyloid;Amyloid deposition;Animal Model;Animals;anti-depressive agents;apolipoprotein E-4;Attention;Benign;Biological Markers;blood-based biomarker;Brain;Cerebrospinal Fluid;Cognition;Cognitive;cognitive performance;cognitive task;cost;Cross-Over Trials;Data;Dementia;Development;disability;Disease;Disease Progression;Double-Blind Method;Drug Targeting;effective therapy;executive function;Family Caregiver;FDA approved;follow-up;Functional Magnetic Resonance Imaging;glymphatic system;Health Care Costs;hemodynamics;Hippocampus;Home;Human;Impaired cognition;Impairment;improved;improvement on sleep;Individual;informant;Insecta;Intercellular Fluid;interstitial;Link;Measures;Mediating;Memory;memory consolidation;mild cognitive impairment;Modification;Morbidity - disease rate;neural;neuropsychiatric symptom;Observational Study;off-label use;older adult;Outcome;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patient Self-Report;Pattern;Performance;Persons;Pharmaceutical Preparations;Phase;phase III trial;Placebo Control;Placebos;Polysomnography;poor sleep;prevent;primary outcome;Process;processing speed;prodromal Alzheimer's disease;Public Health;Quality of life;Randomized;Research Personnel;response;Rest;risk mitigation;Rodent;Safety;secondary outcome;side effect;Sleep;Sleep Deprivation;Sleep disturbances;Sleep Fragmentations;sleep onset;Slow-Wave Sleep;Study models;Surrogate Markers;symptom treatment;tau Proteins;tau-1;Testing;Therapeutic;therapy development;Time;Trazodone;trial comparing;vigilance;Wakefulness

PROJECT_TITLE: RCT Targeting Cognition in Early Alzheimer's Disease by Improving Sleep with Trazodone (Rest)


NIH_SPENDING_CATS: Diabetes;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Evidence that leukocytes and inflammation contribute to the development of diabetic retinopathy is accumulating. This proposal will focus on the role of a neutrophil protease in the pathogenesis of the retinopathy, and toxicity to retinal endothelial cells as a result of transfer of the protease from neutrophils to the endothelial cells via extracellular vesicles. The insights learned from these studies can lead to development of novel and effective therapies that inhibit the development of diabetic retinopathy by targeting a protease secreted by neutrophils or the subsequent cleavage of Gasdermin D

PI_NAMEs: SKOWRONSKA-KRAWCZYK, DOROTA  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Acute Lung Injury;Adherence;Animals;Area;Binding;Blood capillaries;Blood Vessels;CASP1 gene;Cell Death;cell injury;Cell membrane;Cell Survival;Cells;Cessation of life;Characteristics;Cytoplasmic Granules;cytotoxic;cytotoxicity;Data;Development;Diabetes Mellitus;diabetic;Diabetic mouse;Diabetic Retinopathy;effective therapy;Elastases;Endothelial Cells;Endothelium;extracellular vesicles;Eyedrops;Failure;Growth;in vivo;Individual;Inflammation;Inflammatory;insight;Intercellular adhesion molecule 1;Laboratories;Learning;Leukocyte Elastase;Leukocytes;Mediating;Membrane;Mus;neutrophil;neutrophil elastase inhibitor;non-diabetic;novel;novel therapeutics;pancreatic elastase II;Pathogenesis;pathogenic microbe;Pathway interactions;Patients;Penetration;Peptide Hydrolases;pharmacologic;Play;Process;Proteins;Research;Research Proposals;Research Subjects;response to injury;Retina;Retinal Degeneration;Retinal Diseases;retinal ischemia;Retinal Neovascularization;Role;Secondary to;Serine Protease;Signal Transduction;Systemic Therapy;therapeutic target;tissue injury;Toxic effect;Vascular Endothelial Growth Factors

PROJECT_TITLE: Neutrophil elastase and Gasdermin D in diabetic retinopathy

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Public Health Relevance Statement Over 40 million anesthetics are annually delivered to patients in this country. The proposed program will train anesthesiology/perioperative medicine physician-scientists to be researchers, whose goal will be to advance and improve care in anesthesiology/perioperative medicine for recipients of healthcare in the United States.

PI_NAMEs: KELZ, MAX  (contact)

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TITLE: Physician Postdoctoral Research Training in Perioperative Medicine (PPRTPM)


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Lung;Lung Cancer;Prevention;Screening and Brief Intervention for Substance Misuse;Substance Misuse;Tobacco;Tobacco Smoke and Health

PHR: NARRATIVE Lung cancer is the most common non-AIDS defining malignancies among people living with HIV/AIDS. This implementation science study integrates a smoking cessation intervention, which is lacking in Botswana, into a real-world HIV care system.

PI_NAMEs: CHARURAT, MANHATTAN E (contact);HIMELHOCH, SETH S;MBONGWE, BONTLE

PROGRAM_OFFICER_NAME: ALARO, JAMES R

PROJECT_TERMS: Abstinence;Address;Adoption;Africa South of the Sahara;Agreement;Assessment tool;Baltimore;Biochemical;Botswana;Cancer Burden;Cancer Control;cancer prevention;care systems;Caring;Case Manager;Clinic;Clinical effectiveness;clinical research site;combustible tobacco;comorbidity;Control Groups;cost effectiveness;Demographic and Health Surveys;design;Development;Effectiveness;effectiveness evaluation;effectiveness/implementation study;evidence base;Evidence based intervention;follow-up;Formularies;Fostering;Government;Health;Health care facility;Health system;HIV;HIV Infections;HIV/AIDS;implementation fidelity;implementation science;implementation strategy;indexing;Information Systems;Infrastructure;Intervention;intervention delivery;intervention program;low and middle-income countries;Malignant neoplasm of lung;Malignant Neoplasms;Maryland;Monitor;Nurses;Outpatients;Participant;Persons;Pharmaceutical Preparations;Policies;Population;Premature Mortality;Prevalence;Prevention strategy;Program Sustainability;programs;Psychological reinforcement;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research Design;routine practice;Sample Size;screening, brief intervention, referral, and treatment;smoking abstinence;smoking cessation;Smoking Cessation Intervention;smoking prevalence;Southern Africa;standard of care;Structure;syndemic;Time;Tobacco;tobacco products;Tobacco use;Training;trial comparing;United States National Institutes of Health;Universities;varenicline;Work

PROJECT_TITLE: Botswana Smoking Abstinence Reinforcement Trial (BSMART)


ORG_CITY: MINNEAPOLIS

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Narrative The Minnesota IRACDA Program is a collaboration between the University of Minnesota and the nearby community colleges of Normandale Community College (NCC) and North Hennepin Community College (NHCC), that provides a diverse cohort of postdoctoral scholars in the biomedical sciences with rigorous scientific research training, pedagogical instruction and experience in teaching, mentoring, and career development guidance. The Minnesota program is accomplishing the goals of the NIH IRACDA program of enhancing diversity in the biomedical workforce both through placement of our diverse scholars into faculty and research-related jobs, and also because the scholars are mentors and role models for the large minority and disadvantaged student populations at the Community Colleges.

PI_NAMEs: GREENSTEIN, DAVID IRWIN (contact);WILLETT, JULIA

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Address;Benchmarking;Biomedical Research;career;career development;cohort;Collaborations;Communication;community college;Creativeness;Degree program;Development;Disparity;Doctor of Philosophy;Education;Educational process of instructing;Educational workshop;equity, diversity, and inclusion;evidence base;Exclusion;experience;Faculty;Funding;Goals;Grant;Institution;Instruction;lecturer;Low income;Mentors;Mentorship;Minnesota;minority student;minority undergraduate;Modernization;Occupations;Population Heterogeneity;Positioning Attribute;Postdoctoral Fellow;professor;programs;Publications;racial minority;recruit;Research;Research Personnel;Research Training;Science;Science, Technology, Engineering and Mathematics Education;Scientist;STEM research;student participation;Talents;Techniques;tenure track;Training;undergraduate student;Underrepresented Minority;Universities;Urban Population;Writing

PROJECT_TITLE: The Minnesota IRACDA Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The proposed research seeks to understand how different organisms tune similar molecular systems to sense their specific environment. We will study the structure and function a newly discovered family of sensory receptors found in cephalopods. These receptors are closely related to human neurotransmitter receptors. Comparisons between receptors evolved to function in chemosensory predation and those involved in signaling in the brain will reveal the core conserved machinery of the receptors, and how they can vary to suit distinct behavioral needs.

PI_NAMEs: BELLONO, NICHOLAS ;HIBBS, RYAN E (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TITLE: Structural basis for sensory receptor function

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Vaccine Related

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE The proposed research is relevant to public health due to the significant need for an HIV cure. The project will apply an innovative new approach known as structure-based network analysis and will determine whether epitopes identified by the algorithm can serve as valuable targets in a rationally designed, therapeutic CTL- based vaccine for HIV. Thus, the proposed work is relevant to the NIH's mission to seek and apply knowledge to lengthen life and reduce illness.

PI_NAMEs: GAIHA, GAURAV DAS (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, GERARD

PROJECT_TERMS: Adoptive Transfer;Algorithms;Alleles;Anatomy;antiretroviral therapy;Area;Blood;CD4 Positive T Lymphocytes;Cell Separation;Cells;Chronic;Clone Cells;Coculture Techniques;Collaborations;Core Facility;Cytolysis;Cytotoxic T-Lymphocytes;Data;deep sequencing;design;DNA;Drug resistance;Drug toxicity;economic implication;Effectiveness;Epidemic;Epitopes;Fellowship;gastrointestinal;Goals;HIV;HIV vaccine;HIV/AIDS;humanized mouse;Impairment;in vivo;Individual;innovation;Investigation;Investments;Knowledge;latent HIV reservoir;Life;Link;Mediating;Medical;Methodology;Mission;Modality;mouse model;Mutagenesis;Mutate;Mutation;novel;novel strategies;novel therapeutics;Pathway Analysis;Patients;peripheral blood;Pharmaceutical Preparations;Postdoctoral Fellow;prevent;Progressive Disease;protein structure;Proteome;Public Health;Publishing;rational design;Research;resistance mutation;Resources;response;Rest;Science;Site;Structure;T cell response;T cell therapy;T-Lymphocyte Epitopes;theories;Therapeutic;therapeutic vaccine;therapeutically effective;Tissue Sample;Tissues;United States National Institutes of Health;Vaccine Design;Vaccines;Viral;viral rebound;Viral reservoir;Virus;Virus Latency;Virus Replication;Work

PROJECT_TITLE: Exploiting Highly Networked CTL Epitopes to Achieve a Functional HIV Cure


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Lung;Pulmonary Hypertension;Rare Diseases

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PUBLIC HEALTH RELEVANCE The proposed research is relevant to public health because the technology tested here could be used to noninvasively monitor pulmonary arterial hypertension, a disease of the blood vessels in the lungs that causes heart failure, and determine how vascular changes result in changes in gas exchange physiology. This novel technology could allow for novel strategies for treating and monitoring patients with pulmonary arterial hypertension. Thus, the proposed research is relevant to the part of NIH's mission to develop fundamental knowledge and application of that knowledge to enhance health and reduce illness.

PI_NAMEs: DRIEHUYS, BASTIAAN ;RAJAGOPAL, SUDARSHAN K (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: 3-Dimensional;Address;Appointment;arteriole;Biological Markers;Blood capillaries;Blood gas;blood pressure elevation;Blood Vessels;Blood Volume;Cardiac Catheterization Procedures;Cell Proliferation;Cessation of life;Clinic;Clinical;clinical care;Defect;Diagnosis;Disease;disease diagnosis;Disease Progression;Early Diagnosis;Echocardiography;Exposure to;Fibrosis;follow-up;Foundations;Future;Gases;Health;Heart Diseases;Heart failure;heart function;Hematological Disease;hemodynamics;Histology;Histopathology;Hospitalization;Human;Hypoxia;improved;Inflammation;Knowledge;Life;Link;Lung;Lung Diseases;lung imaging;Lung Transplantation;Magnetic Resonance Imaging;Maps;Measures;Methods;Mission;Modeling;Monitor;Monocrotaline;Morbidity - disease rate;mortality;MRI Scans;new technology;non-invasive monitor;noninvasive diagnosis;novel;novel strategies;Outcome;Pathologic;Pathology;Patient Monitoring;Patients;Pattern;Pharmacotherapy;Phenotype;Physiology;pre-clinical;Pre-Clinical Model;Process;prognostic;Proliferating;Public Health;public health relevance;pulmonary arterial hypertension;Pulmonary Hypertension;Pulmonary Pathology;pulmonary vascular disorder;pulmonary vascular remodeling;Rattus;Research;response;right ventricular failure;Severities;Signal Transduction;single-cell RNA sequencing;Specificity;Spectrum Analysis;standard of care;Technology;Testing;Time;Transplantation;treatment response;United States National Institutes of Health;Walking;Xenon

PROJECT_TITLE: Xenon MRI in Pulmonary Hypertension

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]