ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: NARRATIVE The research program proposed here will provide insights into the guidance cues that support long-distance collective migration of the caudal visceral mesoderm (CVM) in the Drosophila embryo, a process that is required for the assembly of the midgut musculature. Due to the similarities between CVM development and intestinal smooth muscle cell (ISMC) specification in vertebrates, studying CVM cell migration has the potential to provide insight into the basis for human congenital defects such as familial visceral myopathy (FVM). Furthermore, anoikis, or the programmed cell death (PCD) of migrating cells that have detached or adhered to an inappropriate substrate, has been observed in CVM cells; as anoikis resistance is a hallmark of metastatic cancer, the CVM cell migration model has the potential to provide widely-applicable insights into the developmental and pathological mechanisms governing organogenesis and disease.

PI_NAMEs: STATHOPOULOS, ANGELIKE  (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Ablation;Anoikis;Anterior;Apoptosis;Area;Attenuated;attenuation;Automobile Driving;Biological Assay;Biological Models;bone morphogenetic protein receptors;Candidate Disease Gene;Cell Communication;Cell Death;cell motility;Cell Proliferation;Cell Survival;cell type;Cells;Chemotactic Factors;Chemotaxis;Chromosome Mapping;cohort;Congenital Abnormality;Cues;Data;Defect;Development;Disease;Disseminated Malignant Neoplasm;Distant;Drosophila genus;Embryo;Embryonic Development;Environment;Equilibrium;Exhibits;Fibroblast Growth Factor;Fibroblast Growth Factor Receptors;G-Protein-Coupled Receptors;Genes;Genetic;Genetic Screening;Human;Image;imaging approach;in vivo;innovation;insight;Integral Membrane Protein;Intestines;Invaded;Ligands;Malignant Neoplasms;Mediating;Mesoderm;Mesoderm Cell;Midgut;migration;Modeling;Movement;Muscle;mutant;Mutation;Myoblasts;Names;novel;optogenetics;Organ;Organogenesis;Pathologic;Pathway interactions;Pattern;Peptide Hydrolases;Population;prevent;Primordium;Process;programs;Regulation;Research;Resistance;Rest;Role;Signal Pathway;Signal Transduction;Smooth Muscle Myocytes;spatiotemporal;Specific qualifier value;Stereotyping;Structure of primordial sex cell;System;Techniques;Testing;therapeutic target;Time;tool;Transcript;Transforming Growth Factor beta;tumorigenesis;Vertebrates;Visceral;Visceral Myopathies;Visualization

PROJECT_TITLE: Investigating how sequentially acting cues guide long-distance cell migration in vivo within embryos

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(02)M]


ADMINISTERING_IC: OD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Machine Learning and Artificial Intelligence

ORG_CITY: ATLANTA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PATHOLOGY

ORG_FIPS: US

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative The primary goal of this project is to use network analyses to construct a Feeding Interaction Network using automated feeding data collected from animals living in large breeding groups at the Yerkes National Primate Research Center. If successful, these models will identify groups at risk for social instability before the onset of fighting and injury. The application of automated feeding data in the social management of captive colonies of rhesus macaques represents a paradigm shift from more conventional practices.

PI_NAMEs: ETHUN, KELLY F (contact)

PROGRAM_OFFICER_NAME: ZOU, SIGE

PROJECT_TERMS: Adult women;Affect;affiliative behavior;Aggressive behavior;Animal Feed;animal resource;Animals;Behavior;behavior observation;Behavioral;Birth;Breeding;Case Study;cohesion;Communities;Complex;Consumption;Contracts;Data;data-driven model;Deposition;Detection;Disease Outbreaks;Eating;Ensure;Estradiol;Exhibits;Family;feeding;Female;fighting;Frequencies;Funding;Goals;Health;improved;Injury;Intake;Lactation;Macaca mulatta;Machine Learning;machine learning algorithm;machine learning model;member;Methodology;Mission;model building;Modeling;Monitor;Monkeys;network models;Ovulation;Pathway Analysis;Pattern;Phase;Populations at Risk;Practice Management;pregnant;Primates;Progesterone;Publishing;Reporting;reproductive;Research;Research Subjects;Risk;season of birth;Seasons;Signal Transduction;social;social attachment;Social Dominance;Social Network;social relationships;Social support;social unrest;Structure;Subgroup;Testing;Time;Trauma;United States National Institutes of Health;wound

PROJECT_TITLE: Feeding interaction network analyses enhance management of NHP breeding groups

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-P(55)R]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pain Research;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Co-morbid chronic pain-depression is common among older Blacks and this co-morbidity worsens physical and emotional function. Access to evidence based non-pharmacological management is limited by systemic racism, stigma, and the lack of culturally-tailored care. Mindfulness based cognitive therapy (MBCT) is an evidence-based, non-pharmacological intervention that could address the social-determinants of the chronic pain-depression co-morbidity among older Blacks, but it requires tailoring. The proposed study will establish the feasibility, acceptability and credibility of Quiet Focus, a cultural adaptation of MBCT aimed at the chronic pain-depression co-morbidity among older Blacks in the community.

PI_NAMEs: PHAM, TONY V (contact)

PROGRAM_OFFICER_NAME: JEAN-FRANCOIS, BEDA

PROJECT_TERMS: Abbreviations;acceptability and feasibility;Address;Adult;Aging;Award;Benchmarking;Biometry;Black Populations;Black race;Boston;Bypass;Capital;career;Caring;Characteristics;chronic depression;Chronic Disease;chronic musculoskeletal pain;chronic pain;chronic pain management;clinical practice;Clinical Trials;Communities;community advisory board;community engaged intervention;community engaged research;community engagement;comorbid depression;comorbidity;Complementary Health;cost;Data;Dose;Educational workshop;efficacy evaluation;efficacy trial;Elderly;Elements;Emotional;emotional functioning;Environment;evidence base;experience;Face;First Generation College Students;Focus Groups;Funding;Future;Goals;Health;Hour;improved;Individual;Infrastructure;Institution;Institutional Racism;instructor;Integrative Medicine;interest;Intervention;intervention refinement;Interview;Link;Lived experience;Manuals;Medicine;Meditation;meetings;Mental Depression;Mental Health;Mentors;Mentorship;Methods;Mind-Body Intervention;mindfulness based cognitive therapy;Modeling;National Center for Complementary and Integrative Health;Nonpharmacologic Therapy;older adult;Older Population;Outcome;Pain;Pain management;pain outcome;people of color;Persons;Physical Function;Prayers;preference;Preparation;primary outcome;Procedures;programs;Protocols documentation;Psychiatrist;public health priorities;recruit;Refugees;Research;research and development;Research Methodology;Research Personnel;Research Project Grants;Services;social determinants;social stigma;Son;Teacher Professional Development;Testing;therapy development;Time;Training;Training Programs;Travel;Underrepresented Populations;underserved community;Underserved Population;Vietnamese;volunteer;Work

PROJECT_TITLE: Mindfulness-Based Cognitive Therapy for the chronic pain-depression co-morbidity among older Blacks in the community; The Quiet Focus study


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: KANSAS CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE The storage of fats (lipids) in fat tissue is crucial for persevering insulin sensitivity and metabolic health. This proposal will examine how fat tissue storage of bioactive lipids prevents their accumulation and damaging effects on other tissues such as muscle and liver. These findings have the potential to generate novel therapeutic targets for improving obesity-induced insulin resistance and related diseases.

PI_NAMEs: LUTKEWITTE, ANDREW  (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: abdominal fat;Acetylation;Acid Phosphatase;adipocyte differentiation;Adipocytes;Adipose tissue;Animals;Award;Blood;Blood Vessels;Body Weight decreased;Cardiometabolic Disease;cardiometabolism;career development;Cell Culture Techniques;comorbidity;Data;Deacetylation;Development;Development Plans;Diglycerides;Disease;enzyme activity;Enzyme Inhibition;Fatty acid glycerol esters;Funding;Gene Expression;Geriatrics;Glucose Clamp;Goals;Half-Life;Health;Human;Hyperinsulinism;improved;in vivo;Inflammatory Response;Insulin;Insulin Resistance;insulin sensitivity;insulin signaling;Isotopes;Knockout Mice;Knowledge;Laboratories;Learning;Link;lipid biosynthesis;lipid metabolism;lipidomics;Lipids;lipine;Lipolysis;Lipoproteins;Liver;liver injury;Lysine;lysophosphatidic acid;Mediating;Mediator;medical schools;Mentors;Metabolic;metabolic phenotype;Metabolic stress;Metabolism;metabolomics;Modeling;Modification;Molecular;mouse model;Mus;Muscle;Mutagenesis;new therapeutic target;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutritional Science;Obese Mice;obese patients;Obesity;overexpression;particle;Pathology;peer coaching;Persons;Phosphatidate Phosphatase;Phosphatidic Acid;Physiology;Plasma;Positioning Attribute;Post-Translational Protein Processing;Postdoctoral Fellow;preservation;prevent;Productivity;Protein Acetylation;Proteins;Reporting;Research;research and development;Research Personnel;Research Support;Research Training;Risk;Role;Scientist;Secure;Signal Transduction;Skeletal Muscle;skills;Techniques;Testing;Thinness;Time;Tissues;Tracer;Training;Triglycerides;Universities;uptake;Washington;Work

PROJECT_TITLE: Adipose-Specific Phosphatidic Acid Acid Phosphatase Activity of Lipin 1 Regulates Systemic Insulin Sensitivity

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: This proposal investigates the mechanism and function of mycobacterial dynamin-like proteins in extracellular vesicle formation, and the relevance of vesicle production to the ability of Mycobacterium tuberculosis to manipulate immune cell function, and cause disease.

PI_NAMEs: RODRIGUEZ, GLORIA MARCELA (contact);SALGAME, PADMINI

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Affect;Antibiotic Resistance;Antibiotics;Attenuated Vaccines;Bacteria;Biochemical;Biochemistry;Biogenesis;Cell Communication;Cell Physiology;Cells;Communication;Complement;Complex;Data;defense response;Disease;Dynamin;Environment;Etiology;Eukaryotic Cell;experimental study;extracellular;extracellular vesicles;Genetic;Goals;Granulomatous;Host resistance;Human;Immune;Immune response;Immune system;immunoregulation;In Vitro;in vivo;Individual;Infection;Inflammatory;Intervention;Knowledge;loss of function mutation;Macrophage;Mediating;member;Membrane;membrane biogenesis;Molecular;mouse model;mutant;Mutation;mycobacterial;Mycobacterium tuberculosis;Natural Immunity;novel;Organism;pathogen;Pathogenesis;Pathologic;Persons;Play;Positioning Attribute;Prevalence;prevent;Production;Prokaryotic Cells;Property;Protein Family;Proteins;Public Health;Research;resistant strain;Role;Shapes;Structure;success;Testing;Tuberculosis;Vesicle;vesicular release;Virulence;Virulence Factors;Work

PROJECT_TITLE: Role of mycobacterial dynamin-like proteins in the biogenesis of membrane vesicles, and host-pathogen interactions

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Complementary and Integrative Health;Mental Health;Mental Illness;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Human research demonstrates strong effects of nasal breathing on emotion and brain activity. A better understanding of the underlying neural mechanisms in animal models will help to develop more effective interventions to enhance physical and mental health for people, especially those who suffer from mental illness such as anxiety and panic disorder, depression, and post-traumatic stress disorder.

PI_NAMEs: MA, MINGHONG  (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Ablation;Air Movements;Animal Model;Anterior;Anxiety Disorders;anxiety reduction;Atlases;Axon;Behavior;Behavioral;Bombesin Receptor;Brain;Breathing;cell type;Cells;cognitive function;conditioned fear;CRISPR/Cas technology;Data;effective intervention;Electrophysiology (science);Emotional;Emotions;foot;Freezing;Fright;gene-editing approach;Genes;Genetic;Genus Tenia;Hippocampus;Human;In Situ Hybridization;in vivo;insight;interdisciplinary approach;Knock-in Mouse;Label;Learning;Maps;Mechanical Stimulation;Medial;Mediator;Meditation;Mental Depression;Mental disorders;Mental Health;mitral cell;molecular marker;Mus;Neocortex;neural;neural circuit;Neural Pathways;neuromechanism;Neurons;Nose;Odors;olfactory bulb;Olfactory Cortex;Olfactory Epithelium;olfactory nuclei;Olfactory Pathways;olfactory sensory neurons;optogenetics;Output;Panic Attack;Panic Disorder;patch clamp;Pathologic;Pathway interactions;Pattern;Periodicity;Peripheral;Persons;physical conditioning;Play;Post-Traumatic Stress Disorders;Prefrontal Cortex;Property;Psyche structure;Research;Respiration;response;Retrieval;Rodent;Role;Shapes;Shock;Slice;Source;Stress;Structure;Synapses;Testing;tool;transmission process;Viral;Yoga

PROJECT_TITLE: Olfactory Modulation of Respiration-Entrained Brain Activity and Behavior


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: FARGO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: NORTH DAKOTA STATE UNIVERSITY

ORG_STATE: ND

PHR: PROJECT NARRATIVE CDTSPC is the first and only COBRE Center in North Dakota dedicated to foundational and translational studies on pancreatic cancer. In Phase II, the Center will emphasize translational aspects and expand sustained research funding opportunities for the Junior Investigators. The proposed expansion of research infrastructure will augment the critical mass of researchers, Core Facilities, and equipment at NDSU, resulting in a nationally recognized, self-sustaining Center on pancreatic cancer.

PI_NAMEs: VENKATACHALEM, SATHISH  (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: American Cancer Society;Animals;Award;Big Data;biobank;Bioinformatics;Biological Models;Biomedical Research;Biometry;Biostatistics Core;career;Centers of Research Excellence;Cessation of life;Clinical;Collaborations;Core Facility;COVID-19 pandemic;Death Rate;Dedications;design;Desmoplastic;Diagnosis;Diagnostic;Disease;doctoral student;Drug Delivery Systems;Drug Targeting;effective therapy;Elements;Environment;Epigenetic Process;Equipment;Evaluation;Faculty;Fluorescence;Foundations;Funding;Funding Opportunities;Genetic;Genetic Engineering;genetic risk factor;Goals;graduate student;Grant;Histocytochemistry;Histology;Hospitals;Human;Image;imaging modality;Immunohistochemistry;improved;Incidence;Infrastructure;Institution;Journals;Machine Learning;Maintenance;Malignant neoplasm of pancreas;Malignant Neoplasms;Medical center;member;Mentors;Mission;model development;Modeling;mouse model;Multiomic Data;Mus;Mutation;Nebraska;Neoplasm Metastasis;North Carolina;North Dakota;novel therapeutics;pancreatic cancer model;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Paper;patient derived xenograft model;Patients;Peer Review;Phase;Pilot Projects;Postdoctoral Fellow;Privatization;professor;Publications;Publishing;R24;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Science;Scientist;Secure;Services;Small Business Innovation Research Grant;Social Distance;subcutaneous;Survival Rate;Symptoms;tenure track;Therapeutic;Therapeutic Agents;Time;Tissues;Translational Research;translational study;Travel;tumor;United States National Institutes of Health;Universities;University of Texas M D Anderson Cancer Center;Work

PROJECT_TITLE: Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

PHR: Project Narrative: The proposed “Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer” in North Dakota State University will continue to support foundational and translational studies devoted to controlling pancreatic cancer at cellular and animal model levels. The Administrative Core will serve as the organizational point of contact for all components of the Center. The Center will enhance the biomedical research infrastructure of the university. The Administrative Core of the Center will facilitate and ensure that all the components of the Center are functioning efficiently and successfully. __________________________________________________________________________________________

PI_NAMEs: MALLIK, SANKU  (contact)

PROJECT_TERMS: Acceleration;Address;Advisory Committees;American Association of Cancer Research;American Cancer Society;Animal Model;Biomedical Research;Budgets;Cancer Biology;career;career development;Cell model;Clinical;Collaborations;competitive environment;Core Facility;Dedications;Department of Defense;Diagnostic;Disease;Educational workshop;Ensure;Environment;Equilibrium;Equipment;Experimental Designs;Extramural Activities;Faculty;Family;Fostering;Foundations;Funding;Funding Mechanisms;Goals;Grant;improved;Infrastructure;Leadership;Malignant neoplasm of pancreas;Malignant Neoplasms;Manuscripts;meetings;member;Mentors;Modeling;National Institute of General Medical Sciences;North Dakota;operation;Organization and Administration;organizational structure;peer;Peer Review;Personnel Management;Persons;Phase;Pilot Projects;Preparation;Process;programs;Published Comment;R24;Recommendation;recruit;Reporting;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Science;Scientist;Secure;Senior Scientist;Services;skills;Strategic Planning;Structure;success;symposium;Technical Expertise;Therapeutic;Training;Translational Research;translational scientist;translational study;United States National Institutes of Health;Universities;virtual;Work;Writing

PROJECT_TITLE: Administrative Core: Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

PHR: Project Narrative Cancer is a complex disease involving many different types of cells interacting in dozens of ways. Due to this complexity, animal models of cancer are of immense value for discovering new ways to diagnose and treat cancer. In this project, the Animal Core Facility will assist both COBRE-supported researchers and the broader NDSU community with the establishment and maintenance of research paradigms involving animals with the long-term goal of developing new therapeutic options for cancer treatment.

PI_NAMEs: WILKINSON, JOHN CURLEE (contact)

PROJECT_TERMS: Achievement;Address;Advisory Committees;Animal Cancer Model;animal care;Animal Experimentation;Animal Experiments;Animal Housing;Animal Model;Animals;anti-cancer research;Apoptosis;Area;biobank;Biological Models;Biomedical Research;Breeding;cancer diagnosis;Cancer Etiology;cancer therapy;Carcinogenesis Mechanism;career;Cell Communication;cell type;Centers of Research Excellence;Cessation of life;chemotherapeutic agent;Clinical;Clinical Management;Collaborations;Communities;Complement;Complex;Core Facility;Development;Diagnosis;Diagnostic;Disease;Early Diagnosis;Early treatment;efficacy study;Elements;Ensure;Experimental Designs;extend lifespan;Extramural Activities;Faculty;Faculty Recruitment;fluorescence imaging;Fluorouracil;Fostering;gemcitabine;Genetic Engineering;Genetically Engineered Mouse;Goals;graduate student;Histocytochemistry;Histology;Housing;IACUC;imaging approach;imaging modality;Immunocompromised Host;Immunohistochemistry;implantation;improved;in vivo;Individual;Institution;Invaded;irinotecan;KPC model;KRASG12D;Leucovorin;Maintenance;Malignant neoplasm of pancreas;Malignant Neoplasms;Mentors;Methods;Mission;model development;Modeling;Mouse Strains;Mus;National Cancer Institute;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of General Medical Sciences;Neoplasm Metastasis;novel;novel therapeutic intervention;novel therapeutics;oxaliplatin;Pancreatic Ductal Adenocarcinoma;patient derived xenograft model;Patients;Phase;Pilot Projects;Play;Postdoctoral Fellow;Productivity;programs;protocol development;Regimen;Regulation;Research;Research Infrastructure;Research Personnel;Resources;Role;Sampling;Scientist;Senior Scientist;Services;Site;Solid;standard of care;subcutaneous;Survival Rate;Testing;Therapeutic;Tissues;Toxic effect;Training;translational study;treatment response;treatment strategy;tumor;United States;United States National Institutes of Health;working group

PROJECT_TITLE: Animal Core Facility


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Data Science;Digestive Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pancreatic Cancer;Rare Diseases

PHR: Project Narrative Biostatistics and Bioinformatics Core (B2C) As the only Biostatistics and Bioinformatics Core specializing in pancreatic cancer research in the region, the B2C will continue to play an integral role in the Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer (CDTSPC) and the greater North Dakota State University (NDSU) community by providing high-quality, comprehensive study design and data analysis support to all CDTSPC and NDSU researchers. A specific emphasis will be placed on providing this support at all stages of the research process to the Junior Investigators' translational and pre-clinical pancreatic cancer research projects, ensuring that all projects are properly designed and well-powered and increasing the likelihood of securing competitive federally funded research grants. In addition, Phase II of this project will expand the B2C services beyond traditional statistical techniques of the bench and clinical research into other emerging "big data" research areas, including bioinformatics and machine learning.

PI_NAMEs: ORR, MEGAN  (contact)

PROJECT_TERMS: anti-cancer research;Applications Grants;Area;Artificial Intelligence;Big Data;Bioinformatics;Biometry;Biostatistics Core;Cancer Research Project;Career Mobility;Centers of Research Excellence;Clinical Research;Collaborations;Communities;Core Facility;Data;Data Analyses;Data Reporting;Data Scientist;Data Set;deep learning;design;Development;Diagnostic;drug candidate;Early Diagnosis;Early treatment;effectiveness evaluation;Ensure;experience;experimental analysis;Experimental Designs;Experimental Models;experimental study;Faculty;Formulation;Funding;Genetically Engineered Mouse;Human Resources;in vivo;Institution;interest;Knowledge;Machine Learning;Malignant neoplasm of pancreas;member;Mesenchymal Stem Cells;Methodology;Methods;Mining;mouse model;Multiomic Data;Names;nanoengineering;neoplastic cell;North Dakota;oxaliplatin;Pancreas;Peer Review;Phase;Play;Positioning Attribute;pre-clinical;pre-clinical research;preference;Preparation;Process;Publications;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Resources;Role;Sample Size;secondary analysis;Secure;Services;Statistical Data Interpretation;Study models;Techniques;Therapeutic;Tissue Sample;Training;translational barrier;translational scientist;tumor;Universities;Work

PROJECT_TITLE: Biostatistics and Bioinformatics Core Facility


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Digestive Diseases;Nanotechnology;Orphan Drug;Pancreatic Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: PROJECT NARRATIVE Pancreatic ductal adenocarcinoma is one of the most lethal human malignancies, with a median overall survival of less than one year and 5-year survival of 10.8%. Lack of efficient strategies to achieve cytotoxic concentrations of chemotherapeutics in the tumor tissue and the tumor's innate resistance to chemotherapy are significant barriers to improving pancreatic cancer treatment outcomes. The proposed research aims to investigate bioengineered mesenchymal stem cells as a novel drug delivery platform for tumor-selective delivery of a synergistic combination of oxaliplatin and entinostat to improve therapeutic efficacy while minimizing toxicity.

PI_NAMEs: LAYEK, BUDDHADEV  (contact)

PROJECT_TERMS: Acute;acute toxicity;Affect;anti-cancer treatment;Antineoplastic Agents;Apoptosis;Autopsy;Behavior;Biodistribution;Biomedical Engineering;cancer therapy;cell killing;Cells;Charge;chemotherapeutic agent;chemotherapy;Clinical;Combined Modality Therapy;cytotoxic;Cytotoxic agent;Desmoplastic;Diagnostic;Dose;Dose Limiting;Drug Delivery Systems;Drug Kinetics;drug release kinetics;Drug resistance;Drug Targeting;effectiveness evaluation;Encapsulated;Ensure;Formulation;Goals;Growth;HDAC10 gene;Hematology;Histone Deacetylase;Histone Deacetylase Inhibitor;Histopathology;Home;Human;improved;In Vitro;in vitro Model;Literature;Malignant neoplasm of pancreas;Malignant Neoplasms;Maximum Tolerated Dose;Mediating;Mesenchymal Stem Cells;Modality;mouse model;Mus;nanocarrier;nanoengineering;nanoparticle;nanoparticle delivery;nanopolymer;nanotoxicity;neoplastic cell;Neurologic;Normal tissue morphology;novel;novel strategies;novel therapeutics;Organ;Outcomes Research;oxaliplatin;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;Particle Size;Pathway interactions;patient subsets;Pharmaceutical Preparations;Phenotype;Play;pre-clinical research;Protocols documentation;Regimen;Research;Resistance;Role;small molecule;Solid Neoplasm;success;Surface;Survival Rate;System;targeted delivery;targeted treatment;Testing;Therapeutic;Therapeutic Agents;Time;Tissues;Toxic effect;Treatment Efficacy;Treatment outcome;Treatment-related toxicity;tumor;tumor growth;Tumor Tissue;Work

PROJECT_TITLE: Mesenchymal Stem Cell-Based Targeted Combined Therapy for Pancreatic Ductal Adenocarcinoma


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

PHR: Project Narrative: Regardless of all efforts to develop new technologies and treatments, the 5-year survival rate for PDAC remains low. Although crucial for current cancer therapy, the conventional anticancer drugs used to kill tumor cells and damage healthy cells, wreaking havoc on the rest of the body, decreasing treatment efficacy, and favoring de novo carcinogenesis. Especially in hard-to-treat cancers such as pancreatic ductal adenocarcinoma (PDAC), the limitation of the current treatments leads patients to believe, at present, that surgical resection is the only potential cure. Regrettably, only 15-20% of the cases are resectable, the recurrence rate is still high, and the unavoidable rates of long-term survival are dismal. As a solution for the lack of possibilities to increase patients' survival rate, health, and cure during conventional therapy, we propose a new approach to cancer treatment that will selectively kill tumor cells in any proliferative stage with the potential to eradicate the tumor.

PI_NAMEs: GOMES, ROBERTO  (contact)

PROJECT_TERMS: Address;Animal Experiments;Animal Model;Animals;Antineoplastic Agents;antitumor effect;Apoptosis;Autophagocytosis;Binding;Binding Sites;Biodistribution;Biology;Cancer Etiology;cancer therapy;carcinogenesis;Carrier Proteins;Cell Cycle;Cell Cycle Stage;Cell Death;Cell Death Induction;cell killing;Cell Physiology;Cell Proliferation;Cells;Cellular biology;Cessation of life;chemical synthesis;Chemistry;Coatomer Protein;Complex;Computers;conventional therapy;Dependence;design;Diagnostic;Disease;Disease remission;DNA;drug action;drug candidate;Drug Design;drug development;Drug Kinetics;drug synthesis;Drug usage;efficacy evaluation;Endoplasmic Reticulum;endoplasmic reticulum stress;Endosomes;Excision;Generations;Genes;Geometry;Goals;Golgi Apparatus;Guanosine;Guanosine Triphosphate;Health;Homeostasis;Human;Hydrophobicity;improved;inhibitor;Lead;Malignant neoplasm of pancreas;Malignant Neoplasms;Maximum Tolerated Dose;Mediating;model design;molecular modeling;mouse model;Neoplasm Metastasis;neoplastic cell;new technology;Normal Cell;novel strategies;Operative Surgical Procedures;Organic Chemistry;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Pathway interactions;Patients;Pharmaceutical Preparations;Positioning Attribute;Proliferating;protein complex;Protein Complex Subunit;Protein Isoforms;Proteins;prototype;Recurrence;Relapse;Research;Resectable;response;Rest;retrograde transport;Secretory Vesicles;small molecule;Stress;Study models;Survival Rate;Testing;Therapeutic;Time;Treatment Efficacy;Treatment Failure;tumor;Tumor Cell Line;tumor eradication;Validation;Viral;virtual screening

PROJECT_TITLE: Selective inhibition of COPZ1 in PDAC cells


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences;Social Determinants of Health;Substance Misuse

ORG_CITY: DURHAM

ORG_DEPT: BIOLOGY

ORG_NAME: NORTH CAROLINA CENTRAL UNIVERSITY

ORG_STATE: NC

PHR: NARRATIVE For many individuals suffering with an alcohol use disorder, the current treatments for are insufficient, suggesting that novel therapeutic targets should be explored. Research has established that the neuroimmune system is impacted by excessive drinking, and that manipulating the neuroimmune response can be protective against binge-like drinking. The results of the current study will show how binge drinking alters astrocytes, key regulators of the neuroimmune response, as well as whether astrocytes and their signaling pathways represent a novel therapeutic avenues to treat alcohol abuse.

PI_NAMEs: MARSHALL, SIMON ALEXANDER (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Addictive Behavior;Address;Adult;Alcohol abuse;alcohol behavior;alcohol consequences;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol exposure;alcohol misuse;alcohol pharmacology;alcohol use disorder;Alcoholic Intoxication;Alcohols;American;Amygdaloid structure;Animal Model;Anti-Anxiety Agents;Area;Astrocytes;Behavior;Behavioral;binge drinking;Blood;Blood alcohol level measurement;Brain Injuries;Cells;Consummatory Behavior;Consumption;cost;cytokine;Darkness;Data;density;Dependence;designer receptors exclusively activated by designer drugs;Development;drinking;Economic Burden;Ethanol;Ethanol dependence;Event;G alpha q Protein;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;GLAST Protein;glial activation;Glial Fibrillary Acidic Protein;Glutamate Transporter;glutamatergic signaling;Glutamates;Grant;health economics;Healthcare Systems;Heavy Drinking;Immunohistochemistry;immunoreactivity;Individual;Inflammatory;Influentials;innovation;insight;interest;Interleukin-1 beta;Interpersonal Relations;Measures;Mediating;Modeling;Mus;National Institute on Alcohol Abuse and Alcoholism;Nerve Degeneration;neurobiological mechanism;Neurobiology;Neuroimmune;Neuroimmune system;neuroinflammation;Neuronal Plasticity;neurotransmission;new therapeutic target;novel;novel therapeutics;Operative Surgical Procedures;Pathologic;Pattern;pharmacologic;Population;Procedures;Production;promoter;Property;Quantitative Reverse Transcriptase PCR;receptor expression;Recording of previous events;Regulation;Research;response;Role;Safety;sex;Sex Differences;Signal Pathway;Signal Transduction;social;Societies;socioeconomics;Testing;United States;Virus;Work

PROJECT_TITLE: The Functional Implications of Astrocytic GPCR-signaling on Alcohol Abuse


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Cardiovascular;Genetics;Heart Disease;Human Genome;Precision Medicine

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: The Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium has helped to accelerate the discovery of genetic variants associated with common diseases and risk factors. The proposed application will provide infrastructure support for the consortium, including for instance administrative support for day-to-day activities, the organization of two CHARGE-wide meetings per year, and travel support for young investigators.

PI_NAMEs: PSATY, BRUCE M (contact)

PROGRAM_OFFICER_NAME: YARDEN, RONIT I

PROJECT_TERMS: Abbreviations;Acceleration;Address;Age;Aging;Alzheimer's Disease;analytical method;Atherosclerosis Risk in Communities;Award;biobank;Biological Assay;Biological Process;Biology;Body Composition;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;career;catalyst;cohort;Cohort Studies;Collaborations;Coronary Artery Risk Development in Young Adults Study;Data;database of Genotypes and Phenotypes;Diabetes Mellitus;Disease;DNA Methylation;Ecosystem;Educational workshop;Environment;Epidemiology;Event;exome;Fostering;Framingham Heart Study;Frequencies;Funding;Future;Gene Expression Profiling;Genes;Genetic;genetic epidemiology;genetic variant;genome wide association study;genomic data;genomic epidemiology;genomic locus;Genomics;Goals;Grant;Health;Heart;Hispanic Community Health Study;improved;Incentives;indexing;Individual;Infrastructure;insight;International;Jackson Heart Study;Journals;Latino Population;Link;Longitudinal Studies;Malignant Neoplasms;Manuscripts;Measures;meetings;Mendelian randomization;Meta-Analysis;metabolomics;Methods;Multi-Ethnic Study of Atherosclerosis;National Heart, Lung, and Blood Institute;novel;Participant;Phenotype;polygenic risk score;population based;Positioning Attribute;Predisposition;programs;prospective;Prospective, cohort study;Proteomics;Publications;Research;Research Personnel;Resources;Risk Factors;Running;Sample Size;Science;scientific organization;Scientist;stomach cardia;success;System;Testing;therapeutic target;Time;Training;trait;Trans-Omics for Precision Medicine;Travel;United Kingdom;United States National Institutes of Health;Variant;Veterans;volunteer;web site;webinar;whole genome;working group

PROJECT_TITLE: CHARGE consortium: omics discovery for CVD and aging phenotypes

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

PI_NAMEs: BASU, SAIKAT  (contact)

PROJECT_TERMS: Benchmarking;Blood Vessels;cancer care;cancer diagnosis;Cancerous;Cell Culture Techniques;Clinical;clinical diagnosis;Convection;Data;design;Diagnostic;Diffusion;Endothelium;Environment;experimental study;Extracellular Matrix;Extracellular Space;Fiber;Geometry;Human;image processing;Implant;in silico;Liquid substance;Literature;logarithm;Malignant neoplasm of pancreas;Mechanics;Medical;Microfluidics;Modeling;Mus;Necrosis;novel diagnostics;pancreatic neoplasm;Perfusion;Phase;Plasma;Resort;Scanning;Shapes;simulation;Slice;Solid;Solid Neoplasm;spheroids;Starling (law);Stress;Structure;System;Testing;Theoretical model;Therapeutic;tool;trend;tumor;tumor microenvironment;uptake;usability;Vision;Work;X-Ray Computed Tomography

PROJECT_TITLE: Computational and theoretical fluid mechanics modeling for transport in dense tumors


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: HBCD-NC Project Narrative Various adverse and protective environments may affect child development. The Healthy Brain and Child Development National Consortium (HBCD-NC) will follow 7,500 mothers and their children from 24 locations across the U.S. from before birth to 10 years of age to better understand which harmful and protective environments exert the greatest impact on child development. This study will help to improve the health and development of children across the nation.

PI_NAMEs: PEKAR, JAMES J.;SATIN, ANDREW J.;VOLK, HEATHER E (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: 10 year old;Address;Adverse event;Affect;Alcohols;Behavioral;Biological;Birth;Brain;Caregivers;caregiving;Child;child bearing;Child Development;cohort;Communities;Conceptions;COVID-19;critical period;Data;Data Collection;Data Coordinating Center;data integrity;Data Set;data standards;design;Development;DNA;early experience;early life exposure;Electroencephalography;Enrollment;Environment;Environmental Exposure;Environmental Hazards;Epigenetic Process;Ethics;Ethnic Origin;Event;experience;Exposure to;Feedback;General Population;Genes;Goals;hazard;Health;Helping to End Addiction Long-term;Human;improved;Infant;Infection;innovation;insight;Life;Link;Location;Magnetic Resonance Imaging;Malnutrition;maltreatment;Marijuana;Maternal Health;maternal stress;Measures;Methods;Modality;Monitor;Mothers;multidimensional data;multimodality;neurodevelopment;neuroimaging;Newborn Infant;novel;Opiate Addiction;Opioid;opioid misuse;Outcome;Participant;Persons;Physiological;Population;postnatal;Pregnancy;pregnant;Pregnant Women;prenatal;prenatal exposure;Process;protective factors;Protocols documentation;psychologic;Psychopathology;Public Health;Public Policy;Race;recruit;remote assessment;Research;Research Design;Research Personnel;Sampling;Second Pregnancy Trimester;Severities;Shapes;Site;socioeconomics;sound;Speed;stem;Stress;Structural Racism;substance use;Time;Time Study;Tobacco;tool;Toxicant exposure;Training;United States;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: 7/24 Healthy Brain and Child Development National Consortium

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-D(51)R]


NIH_SPENDING_CATS: Genetics;Immunotherapy

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The long-term goal of the proposed research is to understand how cells acquire the capacity to elicit specific responses to environmental cues. We aim to define the mechanistic roles of a novel chromatin remodeling complex in equipping T cells early in development with the potential to kill, secrete cytokines, and promote other T cell-specific functions. Understanding these fundamental processes will allow the modulation of T cell effector programming which can enhance vaccination, cancer immunotherapy and ameliorate autoimmunity.

PI_NAMEs: KOH, ANDREW S (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Achievement;ATP phosphohydrolase;Autoimmunity;base;Biological Models;Biological Process;cancer immunotherapy;Cell Physiology;Cells;Cellular biology;Chromatin;Chromatin Remodeling Factor;clinical application;Complex;Cues;cytokine;Decision Making;Development;effector T cell;experimental study;Foundations;Genes;Genome;Goals;Growth;human DNA;interest;Laboratories;Mediating;Molecular;Molecular Conformation;Motor;novel;Nuclear;Nucleosomes;Process;programs;receptor;Regulation;Research;response;Role;Seminal;Signal Pathway;Stimulus;T-Cell Receptor;T-Lymphocyte;transcription factor;Vaccination

PROJECT_TITLE: Epigenesis of Cell Fate Potential

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative  The PI3K (phosphoinositide 3-kinase)/AKT signaling pathway is one of the most frequently deregulated signaling nodes in virtually all human solid and hematological malignancies. The overall goal of this 7 year application is to dissect the regulation and function of PI3K and AKT proteins in the context of modulating reprogramming of metabolic pathways and identifying downstream mechanisms of PI3K and AKT that lead to tumor initiation and progression. We propose that new findings emerging from this project may lead to new therapeutic opportunities for effectively treating those cancers that harbor PI3K pathway lesions.

PI_NAMEs: TOKER, ALEX  (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: addiction;AKT inhibition;AKT Signaling Pathway;Area;carbohydrate metabolism;cell growth;cell motility;Cell Proliferation;Cell Reprogramming;Cellular Metabolic Process;Chemicals;CRISPR screen;Cytostatics;cytotoxic;Development;Endoplasmic Reticulum;endoplasmic reticulum stress;Enzymes;experience;FRAP1 gene;Gene Combinations;Gene Targeting;Genetic;genetic approach;glycosylation;Goals;Growth Factor;Hematologic Neoplasms;Human;inhibitor;insight;Interruption;Laboratories;Lesion;Link;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Metabolic Pathway;mouse model;novel;novel therapeutics;Oncogenes;Oncogenic;Pathway interactions;Phenotype;Phosphatidylinositols;Phosphotransferases;PIK3CG gene;protein folding;Protein Glycosylation;Protein-Serine-Threonine Kinases;Proto-Oncogene Proteins c-akt;Regulation;response;Signal Transduction;small molecule inhibitor;Solid;targeted treatment;treatment response;tumor initiation;tumor progression;tumorigenesis;Validation;virtual;Vision;Work

PROJECT_TITLE: Discovery, Regulation and Function of the PI 3-Kinase and AKT Pathway in Cancer


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: HOUSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Streamlined and comprehensive molecular profiling of circulating tumor exosomes is critical to unlock the wealth of disease information in these extracellular vesicles. Selective immunocapturing and concentrating of exosomes on a bio-chip examined at microscopic resolution are critical for accentuating the CTE signal among a large background from the vast majority of normal exosomes. We propose to develop a novel technological platform to provide radical advancement in the ability to count single exosomes and associate the surface protein and cargo genetic biomarkers with cancer, a goal aligned with NIH’s mission of developing new approaches critical for cancer diagnostics and detection.

PI_NAMEs: SHIH, WEI-CHUAN  (contact)

PROGRAM_OFFICER_NAME: MULVANEY, SHAWN PATRICK

PROJECT_TERMS: Animals;Antibodies;Area;Benchmarking;Binding;biochip;Biological Markers;Biomedical Research;Biosensing Techniques;Blood;Blood specimen;Blood Volume;cancer biomarkers;cancer cell;Cancer cell line;Cancer Center;Cancer Detection;cancer diagnosis;Cancer Diagnostics;Cancer Patient;cancer therapy;cancer type;Cancerous;care outcomes;Cell Membrane Permeability;Cells;Characteristics;Circulation;Collaborations;cost;cost effective;Data;density;Detection;Detection of Minimal Residual Disease;Devices;Diagnostic;differential expression;digital;Disease;DNA;Doctor of Medicine;Electroporation;Event;Excretory function;exosome;extracellular vesicles;Fluorescence;Fluorescent Probes;Friends;Gastroenterology;Genetic Markers;Genetic Materials;genetic profiling;Genomics;Goals;Harvest;Image;imaging system;Imaging technology;improved;In Situ Hybridization;Individual;innovation;insight;Label;Liposomes;liquid biopsy;Liquid substance;Malignant neoplasm of esophagus;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Measures;Membrane Proteins;Microbubbles;Microfluidics;MicroRNAs;Microscopic;Microscopy;Mission;Molecular;Molecular Profiling;Monitor;nano;nanobubble;nanodisk;nanoplasmonic;nanovesicle;Nature;Needles;Neoplasm Circulating Cells;new technology;novel strategies;operation;Outcome;Paper;Patients;Performance;PET/CT scan;point of care;Positioning Attribute;Process;prognostic;protein biomarkers;Protocols documentation;prototype;Recurrent disease;Research;Research Personnel;Residual Neoplasm;Residual state;Resolution;RNA;Sampling;Sensitivity and Specificity;sensor;Signal Transduction;Specificity;spectroscopic imaging;superresolution microscopy;Surface;Surface Antigens;Surface Plasmon Resonance;Technology;technology development;technology platform;tool;transcriptomics;tumor;tumor DNA;United States National Institutes of Health;Validation;Withdrawal;Work

PROJECT_TITLE: Streamlined and comprehensive circulating tumor exosome profiling by microfluidic arrayed nanoplasmonic sensors and actuators

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Cystic Fibrosis;Genetics;Infectious Diseases;Lung;Rare Diseases

PHR: Project Narrative Pseudomonas aeruginosa, a bacterium that infects people with immune compromise, engages in a process of cell-cell communication called quorum sensing. This project seeks to answer how quorum sensing changes in people with chronic infections, with the idea that these studies will eventually lead to development of new therapies for bacterial infections.

PI_NAMEs: DANDEKAR, AJAI  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acute;acute infection;Animal Model;Architecture;Attention;Automobile Driving;azetidine;Bacteria;Bacterial Antibiotic Resistance;Bacterial Infections;Binding;Biological;Cell Communication;Cell Density;Cell Physiology;Cells;Chronic;chronic infection;Clinical;Code;Culture Techniques;Cystic Fibrosis;cystic fibrosis infection;design;Development;Enzymes;fitness;Future;Gene Cluster;gene conservation;Gene Expression;Gene Expression Regulation;Genes;genetic analysis;Genetic Diseases;homoserine lactone;human pathogen;Immune;Infection;interest;Laboratories;Link;Liquid substance;lonely individuals;Lung;Lung infections;Maintenance;Mediating;Microbial Biofilms;Modeling;Mutation;novel therapeutics;opportunistic pathogen;Patients;peptide synthase;Persons;Population Density;Production;Pseudomonas;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Quinolones;quorum sensing;receptor;Regulation;Role;Signal Transduction;System;Testing;therapeutic target;transcription factor;transcriptome;Virulence;Virulence Factors;Work

PROJECT_TITLE: Quinolone and acyl-homoserine lactone quorum sensing in chronic P. aeruginosa infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-M(91)S]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases

ORG_CITY: CHARLESTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers and is characterized by an expansion of fibroblasts which modulate the tumor microenvironment. This proposal aims to elucidate molecular signatures and functions of cancer associated fibroblast subtypes in PDAC. This research will contribute to fundamental knowledge of PDAC biology, and may ultimately lead to design of more effective therapeutics for PDAC patients.

PI_NAMEs: HAN, LU  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Acceleration;Adult;Agonist;Alleles;antagonist;anti-cancer research;Biological;Biology;Bone Marrow Cells;Cancer Biology;Cancer Center;cancer subtypes;cancer type;Cells;Characteristics;Coculture Techniques;Complex;conditional knockout;Correlation Studies;Data;design;Developmental Biology;Diagnosis;Disease;effective therapy;Embryology;Endoderm;Epithelial Cells;Epithelium;Erinaceidae;experimental study;fetal;Fetal Development;fetal stem cell;Fibroblasts;FOXF1 gene;Future;Gene Deletion;Gene Expression;Gene Expression Profile;Genetic;Genetically Engineered Mouse;Heterogeneity;Human;Immune;In Vitro;in vivo;insight;Knowledge;KRASG12D;Ligands;Light;Malignant neoplasm of pancreas;Malignant Neoplasms;Mesenchymal;Mesenchyme;Modeling;Molecular;Molecular Profiling;mouse model;Mus;neoplastic cell;novel;Oncology;Organ;Organoids;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic tumorigenesis;Paracrine Communication;Pathogenesis;Pathway interactions;Patients;Pattern;Phase;Physiology;Play;Postdoctoral Fellow;programs;Regulation;Research;restraint;Role;Sampling;skills;smoothened signaling pathway;stem;success;targeted treatment;Testing;Therapeutic;therapeutically effective;Tissues;Training;transcription factor;treatment response;treatment strategy;tumor;Tumor Burden;tumor microenvironment;tumor progression;Tumor-Derived

PROJECT_TITLE: Origin, diversification and function of pancreatic cancer associated fibroblasts

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Machine Learning and Artificial Intelligence;Major Depressive Disorder;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Rehabilitation;Serious Mental Illness

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE  Abnormalities in the Positive Valence System (PVS) are associated with depressive symptoms and reduced behavioral activation in mid- and late-life. This study will investigate the engagement of the PVS during exposure to social rewards, part of a novel streamlined psychotherapy for mid- and late-life depression. Use of computational modeling will enable identification of neuroimaging and behavioral profiles associated with greater treatment response, and may guide future personalization of psychotherapy.

PI_NAMEs: SOLOMONOV, NILI  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Addictive Behavior;Age;Aging;Animals;Behavioral;biosignature;career;career development;Clinical;Computer Models;Computing Methodologies;conditioning;Cues;Data;depressive symptoms;design;Development;evidence base;Exposure to;financial incentive;functional improvement;Functional Magnetic Resonance Imaging;Future;Generations;geriatric depression;geriatric major depression;Geriatric Psychiatry;Human;improved;Intervention;Investigational Therapies;K-Series Research Career Programs;Knowledge;late life;Machine Learning;machine learning model;Major Depressive Disorder;Mental Depression;Methodology;middle age;Modeling;National Institute of Mental Health;neural network;Neuroanatomy;Neurobiology;neuroimaging;novel;older adult;Participant;patient oriented research;patient subsets;Performance;Pilot Projects;Positive Valence;Prediction of Response to Therapy;psychoeducation;Psychotherapy;random forest;Randomized;Research Activity;Research Personnel;response;Rest;reward circuitry;Rewards;Risk;Role;Series;Severities;skills;social;Social Interaction;Social support;Structure;Symptoms;System;Technical Expertise;Testing;theories;therapeutic target;Training;Training Activity;treatment response

PROJECT_TITLE: Positive valence systems engagement during social reward exposure psychotherapy for mid- and late-life depression


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative This program trains students to understand both the life of a cell at the molecular level and how this relates to human health. This is achieved through a combination of formal lectures, mentored laboratory-based research, and group-learning experiences, with a foundation of scientific rigor and transparency. The anticipated outcome of this educational experience is to nurture a diverse, close-knit group of students who are equipped to become the next generation of outstanding scientists in a variety of careers.

PI_NAMEs: OBERST, ANDREW ATWELL (contact);ZWEIFEL, LARRY S

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TITLE: Training in Cellular & Molecular Biology

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Narrative Glia play important roles in neural development, synapse plasticity and normal brain function, but it remains largely unknown how glia are involved in stabilizing the synapse through the action of homeostatic mechanisms. Epigenetic regulation of gene expression is a dynamic process that is sensitive to changes in neuronal function in mature nervous systems. In this proposal, we will take advantage of transcriptome profiling, genetic, molecular, cellular, electrophysiological, imaging and bioinformatic approaches to systematically dissect how the glial epigenome responds to chronic perturbations and stabilizes synapse physiology in the nervous system.

PI_NAMEs: WANG, TINGTING  (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Acetyltransferase;Acute;Affect;Alzheimer's Disease;Animal Behavior;Astrocytes;autism spectrum disorder;Biochemical;Bioinformatics;Biological Assay;Brain;Calcium;Calcium Channel;Central Nervous System;Chronic;Chronic Disease;Code;Compensation;Complex;conditional knockout;Data;Development;Disease;Drosophila genus;Electrophysiology (science);Epigenetic Process;epigenetic regulation;epigenome;Epilepsy;Essential Genes;Extracellular Matrix Proteins;Gelatinase A;gene discovery;Gene Expression Regulation;gene function;Genes;Genetic;Genetic Screening;Genetic Transcription;Glutamate Receptor;Glutamates;Hippocampus;Histone Acetylation;histone acetyltransferase;Homeostasis;Human;Image;Impairment;Individual;insight;Knockout Mice;Ligands;Link;Maintenance;Maps;Mediating;Molecular;Mus;Muscle;Nerve Degeneration;Nervous System;neural;neural circuit;neural network;neurodevelopment;Neuroglia;Neuromuscular Junction;neuronal circuitry;Neurons;neuroregulation;neurotransmission;neurotransmitter release;Neurotransmitters;notch protein;novel;Organism;Output;Pathology;Pathway interactions;Physiological;Physiology;Play;postsynaptic;presynaptic;presynaptic neurons;Process;Property;protein complex;receptor sensitivity;Regulation;Reporter;RNA Interference;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Stimulus;Synapses;synaptic function;Synaptic Transmission;Synaptic Vesicles;System;Therapeutic;Toxin;Transcriptional Activation;transcriptomic profiling;ubiquitin isopeptidase;Vesicle;virtual;Visualization;Yeasts

PROJECT_TITLE: Stabilizing Brain Function via Glial Epigenetic Signaling

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ED_INST_TYPE: PRIMATE CENTERS

NIH_SPENDING_CATS: Aging;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurodegenerative;Neurosciences;Parkinson's Disease;Physical Activity;Physical Rehabilitation;Rehabilitation;Telehealth

ORG_CITY: PORTLAND

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Narrative Maximizing independent function during the progressive decline of balance and mobility in older adults with chronic diseases, such as Parkinson's disease (PD), is a unique challenge for rehabilitation. Tele-rehabilitation for balance disorders is relatively unexplored and may be beneficial to older adults who cannot attend in-person rehabilitation. In this project, we will test 80 people with PD to: 1) determine if using wearable sensors at home can improve objective assessment of balance and 2) investigate if balance-focused tele-rehabilitation can improve balance.

PI_NAMEs: KING, LAURIE  (contact);MANCINI, MARTINA

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Balance training;Cardiac;cardiovascular fitness;Chronic Disease;Clinic;Clinical;clinical predictors;COVID-19 pandemic;Discipline;Electrocardiogram;Ensure;equilibration disorder;Equilibrium;evidence base;Evidence based program;Exercise;exercise program;experience;fall risk;falls;Feedback;flexibility;foot;Future;Gait;Gait speed;Goals;Health;Heart Rate;Home;improved;improved outcome;Individual;instrument;Lead;Life;Measures;Monitor;novel;older adult;Older Population;Outcome;Oxygen;pandemic disease;Parkinson Disease;Participant;Patients;Performance;Persons;physical therapist;Population;programs;Publications;Questionnaires;Randomized;Rehabilitation therapy;remote assessment;sensor;skills;standard of care;strength training;Task Performances;telerehabilitation;Testing;Training;Translating;Translations;virtual;virtual assessment;virtual delivery;virtual platform;Walking;wearable device;wearable sensor technology;wireless sensor

PROJECT_TITLE: Balance tele-rehabilitation with wearable technology for older adults with Parkinson disease

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Genetic Testing;Genetics;Health Services;Human Genome

ORG_CITY: MINNEAPOLIS

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Optimizing genetic counseling (GC) quality and improving efficiency of care will require the profession to first be able to accurately and comprehensively measure GC processes and determine which processes are most critical to achieve positive patient outcomes. This research will measure variability in GC processes using a novel, pragmatic measure and link variations in processes and session time to patient-reported outcomes. Using community-based and practitioner-engaged participatory research approaches, this study will test a genetic counseling efficiency intervention with the goal of improving patient reported outcomes in prenatal, cancer, and cardiology settings and increasing GC efficiency by reducing in person visit time.

PI_NAMEs: ZIERHUT, HEATHER  (contact)

PROGRAM_OFFICER_NAME: RIDER, RENEE ANNE

PROJECT_TERMS: Age;Cardiology;Caring;Characteristics;Cluster randomized trial;Communities;community advisory board;compare effectiveness;Complex;Counseling;Data;demographics;design;Education;Effectiveness of Interventions;effectiveness testing;Elements;empowerment;Environment;Evaluation;evidence base;experience;Genetic Counseling;genetic counselor;Genetic Processes;Genetic study;genetic testing;Goals;health literacy;improved;Institution;Intervention;Length;Life;Link;Malignant Neoplasms;Measurement;Measures;Mediating;medical specialties;multilevel analysis;novel;novel strategies;Outcome;Outcome Study;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Pattern;Persons;preference;prenatal;Process;Process Measure;Race;randomized, controlled study;Research;Site;standard of care;Surveys;Testing;Time;Training;usability;Variant;Visit

PROJECT_TITLE: Genetic Counseling Processes Result in Outcomes (GC-PRO) Study


NIH_SPENDING_CATS: Infectious Diseases;Lung;Pediatric;Pneumonia;Pneumonia and Influenza

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Narrative Colonization of the mucosa of the upper airways is the first step in pathogenesis of the leading respiratory tract pathogen Streptococcus pneumoniae. This ongoing project examines host and bacterial factors to understand the key molecular characteristics of colonization including why it i) is prolonged, ii) recurrent, iii) varies markedly by serotype, iv) is most prevalent during infancy, and v) leads to host-to-host transmission.

PI_NAMEs: WEISER, JEFFREY NEAL (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Acute;Address;Adult;Affect;Animal Model;Antibodies;Attenuated;Automobile Driving;Binding;Biology;capsule;CD4 Positive T Lymphocytes;cell injury;Cells;Cellular Immunity;Characteristics;Child;community acquired pneumonia;contagion;cytokine;Data;Disease;experience;extracellular;Genes;Goals;Grant;Herd Immunity;host colonization;Human;humanized mouse;IL17 gene;IL1R1 gene;Immune response;Immunity;Immunize;infancy;Infant;Infection;Inflammation;Inflammatory;Inflammatory Response;insight;Integration Host Factors;Interferon Type I;Interferons;Interleukin-1;Interleukin-1 alpha;Interruption;Investigation;Life;Macrophage;macrophage scavenger receptors;Meningitis;microbial;Modeling;Molecular;monocyte;mouse model;Mucositis;Mucous Membrane;Mus;neutrophil;Neutrophil Infiltration;Nose;novel;opportunistic pathogen;Organism;Otitis Media;pathogen;Pathogenesis;pathogenic bacteria;Pattern;permissiveness;Phagocytes;Phagocytosis;Polysaccharides;Population;Predisposition;Prevention strategy;Primary Infection;Proliferating;Public Health;recruit;Recurrence;Respiratory System;response;Role;scavenger receptor;Sepsis;Serotyping;Signal Transduction;Source;Streptococcus pneumoniae;Streptococcus pneumoniae plY protein;Structure;success;Surface;Testing;Toxin;transmission process;Upper respiratory tract;uptake;Vaccination;vaccine efficacy;Vaccines;Validation

PROJECT_TITLE: Mechanisms of pneumococcal persistence during carriage


ADMINISTERING_IC: TR

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE The PhD in Clinical Investigation (PCI) at the Albert Einstein College of Medicine combines specialized training to prepare biomedical scientists to understand and appreciate the methodologies of clinical and population science, to practice team science as both leaders and members of research teams, and to advance the discipline of translational science. Building from our program's success and increased demand, we seek to evolve PCI by incorporating formalized emphases on integrating TS and health equity (HE) into our training. During the next funding period, we seek to leverage the non-categorical PCI and develop new Research Focus Areas in Infectious Disease, Cancer Outcomes, and Brain Sciences, to provide PCI trainees with funding opportunities that go beyond the four disease-agnostic slots while emphasizing our institutional strengths and applying TS and HE lenses to all trainees' projects.

PI_NAMEs: HOSGOOD, H DEAN  (contact)

PROGRAM_OFFICER_NAME: DIBELLO, ANTHONY THOMAS

PROJECT_TERMS: college;Medicine;pre-doctoral

PROJECT_TITLE: CTSA Predoctoral T32 at Albert Einstein College of Medicine


ORG_CITY: MADISON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Obesity, particularly when accompanied by visceral and hepatic adiposity and low physical fitness, can cause insulin resistance and type 2 diabetes in youth and is a major pediatric public health concern. The mission of the C-DART program is to train post-doctoral MD physician-scientists for productive academic careers in clinical and basic research in prevention and treatment of insulin resistance, type 2 diabetes mellitus and other metabolic complications of obesity and excess visceral and hepatic fat deposition in children.

PI_NAMEs: LAI, HUICHUAN J (contact);REEDER, SCOTT B.

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Childhood diabetes;obesity in children;Research Training;Training Programs

PROJECT_TITLE: Childhood Diabetes and Adiposity Research Training Program (C-DART)


NIH_SPENDING_CATS: Adolescent Sexual Activity;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Sexually Transmitted Infections;Social Determinants of Health;Teenage Pregnancy;Women's Health Research

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: PROJECT NARRATIVE Unintended pregnancy and rising rates of sexually transmitted infections significantly impact the health and economic burden of individuals and communities in the United States. This is particularly true for health disparities faced by Latinx youth. This research extends a study examining structural and interpersonal factors that affect youth violence and sexual health in early adolescence (ages 13 to 15) in a California agricultural community shaped by socioeconomic disparities resulting from generations of Mexican migration. We will follow youth through emerging adulthood (ages 18 to 21) to understand the social factors that affect sexual health outcomes, which will help us develop interventions to improve sexual health and well-being during this critical life transition among Latinx youth who constitute an underserved and growing US population.

PI_NAMEs: MINNIS, ALEXANDRA M (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Address;Adolescence;Adolescent;Adolescent and Young Adult;adolescent health;Affect;Age;aged;agricultural community;Agriculture;Area;Biological Testing;Birth Rate;California;Child;Child Health;Child Rearing;cohort;Communities;Contraceptive Usage;County;Data;Data Collection;Destinations;Developed Countries;Development;Disadvantaged;early adolescence;Economic Burden;Economic Factors;Education;eighth grade;emerging adult;emerging adulthood;Employment;Epidemic;ethnic disparity;family structure;Female;follow-up;Generations;Goals;Health;health care service;health disparity;Home;housing instability;Immigrant;improved;Incidence;Individual;Inequity;Infection;infection rate;Infrastructure;Intergenerational transfer;Intervention;intervention effect;Interview;junior high school;Latina Population;Latinx;Latinx population;Lead;Life;male;Measures;Mediator;Methods;Mexican;migration;neglect;Neighborhoods;Outcome;outcome disparities;Parents;Participant;Pattern;Personal Satisfaction;Population;Population Growth;Population Intervention;Positioning Attribute;Pregnancy;Pregnancy in Adolescence;Prospective, cohort study;racial disparity;recruit;Reproductive Health;Research;retention rate;Risk;Rural;Rural Population;school district;Seasons;sex;sexual debut;Sexual Health;sexual health intervention;Sexually Transmitted Diseases;Shapes;social;social cohesion;social determinants;Social Environment;social factors;socioeconomic disadvantage;socioeconomic disparity;Socioeconomic Factors;structural determinants;teen birth;Teenagers;Time;transition to adulthood;unintended pregnancy;United States;Unsafe Sex;urban area;Visit;Work;young adult;Youth;youth violence

PROJECT_TITLE: Social determinants of sexual health among Latinx adolescents and emerging adults in an agricultural community

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Vector-Borne Diseases

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: These studies will define the molecular interactions and bacterial factors regulating apoptotic and pyroptotic single-cell death outcomes during Yersinia infection, informing potential immunological therapies to better combat bacterial infections. Importantly, the experiments proposed in these studies use powerful single  cell-based approaches, allowing us to define previously unobserved cell fate choices that are masked by bulk population-based assays. Since cell death is a conserved immune response against microbial infections, and apoptosis and pyroptosis result in drastically different consequences to surrounding cells and tissues, findings from this work will inform host-centric therapeutic and experimental approaches to combat bacterial infections.

PI_NAMEs: SCHWARTZ WERTMAN, RONIT  (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Anti-Bacterial Agents;antimicrobial;Apoptosis;Apoptotic;Bacteria;Bacterial Infections;Binding;Biological Assay;CASP1 gene;CASP3 gene;CASP8 gene;Caspase;Cell Cycle Kinetics;Cell Death;Cell Death Induction;Cell membrane;Cells;Cessation of life;Co-Immunoprecipitations;combat;Complex;cytokine;Cytoplasm;Cytosol;Data;Development;Dimerization;Equilibrium;Exhibits;experimental study;extracellular;Family;Fellowship;Fluorescence;Fluorescence Microscopy;Gastroenteritis;Gene Expression;Heterogeneity;Host Defense;human model;human pathogen;Immune;Immune response;Immune signaling;Immunologics;Immunotherapy;Individual;Induction of Apoptosis;Infection;Inflammasome;Inflammatory;Injections;Innate Immune System;innovation;insight;Interleukin-1;Kinetics;Lytic;Macrophage;Masks;Mediating;member;Methods;microbial;Microscopy;Molecular;Morphology;mouse model;Mus;mutant;novel;Outcome;Pasteurella pseudotuberculosis;pathogen;Pathogen detection;pathogenic bacteria;Pathway interactions;Peptide Hydrolases;Physiological;Plague;Play;population based;Predisposition;prevent;Proteins;Regulation;Reporter;response;Role;Signal Induction;Signal Transduction;Site;System;Testing;Therapeutic;Tissues;Virulence;Virulence Factors;Western Blotting;Work;Yersinia;Yersinia enterocolitica;Yersinia infections;Yersinia pestis;Yersinia pseudotuberculosis Infections

PROJECT_TITLE: Defining mechanisms of heterogeneity in cell fate decisions during Yersinia pseudotuberculosis infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07A-A(20)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Diabetes;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Neurosciences;Prevention

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: This multidisciplinary program aims to develop next generation optical coherence tomography (OCT) methods and new imaging biomarkers of retinal microvascular and relative blood flow speeds at the capillary level for understanding and managing diabetic retinopathy (DR). The proposed studies address impactful questions related to clinical DR management, including early disease detection, predicting risk, monitoring disease progression and treatment response, and improving clinical trial efficiency. The long term goal is to create an imaging based tool to guide medical intervention and accelerate drug development, which can lead to better preservation of visual function in DR patients.

PI_NAMEs: FUJIMOTO, JAMES G (contact);WAHEED, NADIA

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Age;age group;Aging;Angiography;Area;Artificial Intelligence;Assessment tool;Background Diabetic Retinopathy;Biological Markers;biomarker identification;Blindness;Blood capillaries;Blood flow;Blood Vessels;Clinical;Clinical Management;Clinical Trials;cohort;Complications of Diabetes Mellitus;Computer software;Cross-Sectional Studies;Data;Data Set;deep learning;Detection;diabetes management;diabetic;diabetic patient;Diabetic Retinopathy;Disease;disease mechanisms study;Disease Progression;drug development;Early Diagnosis;Extravasation;Eye;Generations;glycemic control;Goals;high risk;Image;image processing;imaging biomarker;imaging modality;improved;Individual;inhibitor therapy;innovation;Intervention;Ischemia;Lasers;Location;macula;macular edema;Measures;Mediating;Medical;Methods;Microaneurysm;Monitor;Motion;multidisciplinary;neovascular;neovascularization;next generation;Noise;novel;Optical Coherence Tomography;Outcome;Papillary;Pathogenesis;Patients;Performance;Peripheral;Population;predicting response;Prediction of Response to Therapy;predictive marker;preservation;prevent;programs;proliferative diabetic retinopathy;Protocols documentation;Research;Resolution;response;Retina;Retinal Diseases;Risk;risk prediction;Role;Sampling;Scanning;Severities;Severity of illness;Signal Transduction;Source;Speed;Structure;Surface;Surrogate Markers;Techniques;Technology;Thrombosis;Time;tool;treatment response;vascular abnormality;Vascular Endothelial Growth Factors;Vascular Permeabilities;vessel regression;Vision;Visit;Visualization

PROJECT_TITLE: Novel ultrahigh speed swept source OCT angiography methods in diabetic retinopathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-P(81)S]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Precision Medicine;Social Determinants of Health

ORG_CITY: NEW ORLEANS

ORG_NAME: XAVIER UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative The purpose of the Precision Medicine, Education, Data Informatics, and Community Translation (PREDICT) Institute is to serve as a holistic and replicable framework for the utilization of electronic health data and community translation to affect the decision- making process to improve health outcomes. The PREDICT Institute will extend the technical research exchange (TREX) program at Xavier to include training of current and future underrepresented researchers on health informatics best practices to diversify the research workforce and leverage community-based approaches to enhance clinical research efforts in vulnerable populations. The use of population health and bioinformatics data will demonstrate their value as useful tools in collective approaches required to achieve health equity.

PI_NAMEs: KENNEDY, KATHLEEN B. (contact);WILLIAMS, CHRISTOPHER

PROGRAM_OFFICER_NAME: MARSHALL, VANESSA J

PROJECT_TERMS: Address;Affect;Awareness;Bioinformatics;Clinical Research;college;Communities;Complement;COVID-19 pandemic;Data;data access;data acquisition;Data Analytics;data warehouse;Decision Making;Education;electronic health data;Future;Health;health disparity;health equity;Health Promotion;improved;Informatics;informatics infrastructure;Infrastructure;Louisiana;Mentors;mid-career faculty;minority communities;National Institute on Minority Health and Health Disparities;Outcome;outreach;Pharmacy facility;population health;Postdoctoral Fellow;precision medicine;Process;programs;Public Health Informatics;Reduce health disparities;Research;Research Infrastructure;Research Personnel;Students;Time;tool;Training;translational engagement;Translations;United States National Institutes of Health;Universities;Vulnerable Populations

PROJECT_TITLE: PREDICT (Precision Medicine, Education, Data Informatics and Community Translation) Institute


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Narrative The cellular positive transcription elongation factor b (P-TEFb) is required for transcription of HIV and cellular genes critical for immune functions. However, P-TEFb is severely down-regulated in latently infected cells as well as dysfunctional immune cells frequently occurring in HIV-infected individuals. Our proposed study will establish methods to alter P-TEFb functions in these cells, which would be beneficial for controlling HIV latency and improving immune functions in these individuals.

PI_NAMEs: FUJINAGA, KOH  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: AIDS related cancer;antiretroviral therapy;Biological Assay;CAR T cell therapy;CD4 Positive T Lymphocytes;Cell Physiology;Cells;Chronic;co-infection;Complement Factor B;Complex;cyclin T1;Cyclins;Down-Regulation;effector T cell;Equilibrium;exhaust;Gene Expression;Genes;Genetic Transcription;HIV;Immune;Immune checkpoint inhibitor;immune function;Immune response;Immune system;Immune System Diseases;improved;Individual;Interphase Cell;Kinetics;latent HIV reservoir;Maintenance;Mediating;Memory;Methods;mimetics;Monitor;mutant;neoplastic cell;new therapeutic target;NF-kappa B;nuclear factors of activated T-cells;pathogen;Pathway interactions;Persons;pharmacologic;Phosphorylation;Phosphotransferases;Physiological;Play;Positive Transcriptional Elongation Factor B;posttranscriptional;prevent;Process;Productivity;programs;Protein Dephosphorylation;Proteins;reactivation from latency;Receptor Signaling;Regulation;response;Rest;Role;Small Nuclear Ribonucleoproteins;Stimulation of Cell Proliferation;System;T cell regulation;T-Cell Development;T-Cell Receptor;T-Lymphocyte;tat Protein;TCF Transcription Factor;Transactivation;Transcription Elongation;transcription factor;tumor;ubiquitin-protein ligase;Viral;Virus;Virus Diseases

PROJECT_TITLE: Controlling HIV latency by manipulating CycT1 turnover

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Pediatric;Precision Medicine;Social Determinants of Health

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Page 310

PI_NAMEs: WRIGHT, ROSALIND J (contact)

PROGRAM_OFFICER_NAME: MERCHANT, CAROL

PROJECT_TERMS: Acceleration;Address;anti-racism;Big Data;biobank;Bioinformatics;catalyst;citizen science;Clinical;Clinical Data;Clinical Informatics;Clinical Sciences;clinical translation;Clinical Trials;Collaborations;commercialization;Communication Tools;Communities;community engaged research;community engagement;community-centered;Competence;Computational Biology;Data;data repository;Data Science;Development;digital health;Discipline;Ecosystem;Education;Elderly;Electronic Health Record;Ensure;Entrepreneurship;Environment;Environmental Health;environmental justice;equity, diversity, and inclusion;Evaluation;Feedback;Genomics;Goals;hackathon;Health;health care delivery;health disparity;health equity;Health Sciences;Health system;High Performance Computing;improved;Incentives;Informatics;innovation;innovative technologies;Institution;International;Investments;Justice;Leadership;Learning;Life Cycle Stages;life span;Medical;Methods;Mission;Modeling;Monitor;multi-site trial;National Center for Advancing Translational Sciences;novel;Outcome;Patient Outcomes Assessments;Patients;Pediatric Research;Perinatal;Phase;Population;Population Heterogeneity;precision medicine;Process;programs;Public Health;Research;Research Personnel;Research Support;Role;Science;Secure;skills;smart technologies;social determinants;Social Justice;Social Responsibility;Students;symposium;System;tool;Toxic Environmental Substances;Training;translational applications;Translational Research;translational research program;Translations;Trust;user-friendly;Work;Workforce Development

PROJECT_TITLE: Conduits: Mount Sinai Health System Translational Science Hub


NIH_SPENDING_CATS: Biotechnology;Cancer;Emerging Infectious Diseases;Genetics;HIV/AIDS;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Kaposi’s sarcoma-associated herpesvirus (KSHV) causes several human cancers including Kaposi’s sarcoma, primary effusion lymphoma and multicentric Castleman’s disease. These malignancies inflict morbidity and mortality to the society in US and worldwide. This project will investigate the mechanisms mediating the metabolic pathways supporting the growth and survival KSHV-induced cancer cells, and identify potential therapeutic targets for developing novel prevention and treatment approaches.

PI_NAMEs: GAO, SHOU-JIANG  (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: 3-Dimensional;Acceleration;Acquired Immunodeficiency Syndrome;aerobic glycolysis;Amino Acids;Anabolism;Animals;Biological Models;Biological Process;cancer cell;cancer type;Carbon;Carbon nanoparticle;carcinogenesis;Cell Communication;Cell Culture System;Cell model;Cell Proliferation;cell transformation;Cells;Citric Acid Cycle;Clinic;Diphosphates;effective therapy;effectiveness evaluation;Enzymes;expectation;experimental study;Funding;Genes;genetic manipulation;Glutamine;Goals;Growth;Herpesviridae Infections;Human;Human Herpesvirus 8;in vivo;innovation;Kaposi Sarcoma;knock-down;Ligase;locked nucleic acid;Malignant Neoplasms;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolome;metabolomics;metaplastic cell transformation;Modeling;Morbidity - disease rate;mortality;Multicentric Angiofollicular Lymphoid Hyperplasia;multidisciplinary;Mutagenesis;new technology;new therapeutic target;Nitrogen;novel;novel therapeutics;nucleotide metabolism;Nucleotides;Pathogenesis;Pathway interactions;Patients;Prevention;primary effusion lymphoma;Proliferating;Proteins;Purines;Pyrimidine;reverse genetics;Ribose-Phosphate Pyrophosphokinase;Role;Small Interfering RNA;Societies;Spindle Cell Neoplasm;System;Technology;Testing;Therapeutic Agents;therapeutic target;three dimensional cell culture;Translating;tumor;tumorigenesis;Up-Regulation;Viral;Viral Genes;Warburg Effect

PROJECT_TITLE: Cell model for KSHV infection and genetic manipulation

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Opioid Misuse and Addiction;Opioids;Prescription Drug Misuse;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: LEXINGTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE The REFOCUS project-“Research Examining Factors Associated with the Opioid Crisis among Underserved African Americans” has significant public health implications by examining how structural, social and cultural factors influence nonmedical prescription opioid use (NMPOU) and treatment service use among African Americans across the adult lifespan. Overdose rates have risen exponentially among African Americans but this group has received much less attention. The REFOCUS project will generate data directly applicable to culturally-tailor interventions targeting African American opioid users in order to reduce NMPOU and improve treatment outcomes.

PI_NAMEs: STEVENS-WATKINS, DANELLE J (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: Address;Adult;African American;African American population;Age;Area;Attention;Buprenorphine;Cessation of life;Characteristics;Child Rearing;cohort;Communities;Complex;Comprehension;Criminal Justice;culturally appropriate intervention;Data;Data Sources;design;Dimensions;Discrimination;Disparity;distrust;Dose;drug testing;Drug usage;Employment;Epidemic;Ethnic Origin;evidence base;Evolution;experience;Female;Future;Gender;Goals;health care availability;health communication;Healthcare Systems;Heroin;illicit drug use;Imprisonment;improved;insight;Intervention;Interview;Kentucky;Libraries;life span;Link;Lived experience;low socioeconomic status;male;marginalized population;Mediating;men;Mental Health;Methadone;Methods;misuse of prescription only drugs;Morbidity - disease rate;mortality risk;National Institute of Drug Abuse;older women;opioid epidemic;opioid overdose;opioid use;opioid user;Outcome;Overdose;Pain;Participant;Patients;Pattern;Pharmacotherapy;physical conditioning;pill;Policies;Population;prescription opioid;prescription opioid misuse;Public Health;Race;racial population;recruit;Reporting;Research;Research Personnel;Research Project Grants;response;Risk;Sampling;social;Stress;Structure;Surveys;synthetic opioid;Techniques;Testing;theories;Treatment outcome;treatment services;trend;Underrepresented Populations;Underserved Population;young woman

PROJECT_TITLE: Research Examining Factors Associated with the Opioid Crisis among Underserved African Americans (REFOCUS)

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases

PHR: Project Narrative We recently showed that patients with acute myeloid leukemia (AML) that have high inflammation have poor outcomes and demonstrate that a distinct immune response cooperates with mutational background to promote leukemogenesis, including remodeling of the bone marrow niche expansion of dysfunctional B and T cell populations. We hypothesize that targeting this aberrant immune response will modulate disease progression and therapeutic response. Our proposal is designed to deepen our understanding of the different contributors to inflammation in AML and to delineate the inflammatory response of AML patients of specific molecular subgroups of AML that generally confer high inflammation during different frontline therapies to improve treatment response and survival of these poor-risk patients.

PI_NAMEs: AIFANTIS, IANNIS  (contact);EISFELD, ANN-KATHRIN

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute leukemia;Acute Myelocytic Leukemia;Adult;Affect;Animal Model;Anti-Inflammatory Agents;Antibodies;ATAC-seq;Atlases;B-cell receptor repertoire sequencing;B-Lymphocytes;Blast Cell;Bone Marrow;Bone remodeling;cancer cell;cell transformation;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Censuses;Chromatin;Clinical;Clonality;cohort;Collection;Coupled;Cytarabine;Data;Daunorubicin;design;Development;Disease;Disease Progression;effectiveness testing;Epitopes;Event;Exhibits;exome sequencing;Gene Expression;Generations;Genes;Genetic;Genomics;Genotype;Goals;Hematopoietic stem cells;Human;IL1R1 gene;Immune;Immune response;Immune system;Immunocompetent;immunoregulation;improved;indexing;Inferior;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;inhibitor;insight;Interleukin-1;IRAK1 gene;leukemia;Leukemic Cell;leukemogenesis;Malignant - descriptor;Malignant Neoplasms;Mediating;Mediator;Membrane Proteins;Modeling;Molecular;monocyte;mouse model;multiple omics;Mus;Mutate;Mutation;Myeloid Cells;Myeloproliferative disease;new therapeutic target;novel;Other Genetics;Outcome;Patients;Phenotype;Play;Population;Predisposition;prevent;protein expression;Regimen;Resolution;response;Risk;Role;Sampling;Signal Transduction;single cell ATAC-seq;single cell technology;single-cell RNA sequencing;Specificity;standard of care;Structure;Subgroup;Supporting Cell;survival outcome;T-Lymphocyte;targeted agent;Testing;Therapeutic;Time;Tissues;transcriptome;transcriptome sequencing;treatment effect;Treatment Protocols;treatment response;tumor;tumor microenvironment;tumor progression;tumor-immune system interactions

PROJECT_TITLE: The role of inflammation in the regulation of immune response in acute myeloid leukemia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BTC-Q(80)S]


ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: PUBLIC HEALTH RELEVANCE STATEMENT: This study addresses the unsolved problem of chemotherapy resistance in advanced cancers through evidence- based treatment combinations that target Chase, an enzyme first of its kind. Chase renders the common chemotherapy drug Gemcitabine ineffective. Development of the combinations concurrently with the evaluation of Chase and related molecules as predictors of treatment response could enable the clinical translation of these combinations for the treatment of high-risk, advanced bladder cancers.

PI_NAMEs: LOKESHWAR, VINATA B (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: Ablation;Address;Adjuvant;Adjuvant Chemotherapy;Advanced Malignant Neoplasm;Biological Markers;Bladder;Bladder Neoplasm;cancer cell;Cancer Model;cancer recurrence;CD44 gene;Chemoresistance;chemotherapy;Chemotherapy-Oncologic Procedure;Chondroitin Sulfate Proteoglycan;Chondroitin Sulfates;Chondroitinases;Cisplatin;Clinic;Clinical;clinical translation;Clip;Combined Modality Therapy;comparative efficacy;Cystectomy;Cytidine Deaminase;design;Development;docetaxel;Dose;Drug Kinetics;drug repurposing;Enzymes;Evaluation;evidence base;Evidence based treatment;Failure;FDA approved;gemcitabine;Goals;high risk;Human;Immunocompetent;Immunotherapy;improved;improved outcome;inhibitor;Interstitial Cystitis;intravesical;Intravesical Instillation;JAK2 gene;Malignant neoplasm of urinary bladder;Mediating;Micrometastasis;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Multicenter Studies;Mus;Muscle;muscle invasive bladder cancer;mutant;Myelofibrosis;Neoadjuvant Therapy;Neoplasm Metastasis;novel;Operative Surgical Procedures;Oral;Outcome;Pathway interactions;patient derived xenograft model;Patients;Pentosan Polysulfate;Pharmaceutical Preparations;pre-clinical;predicting response;Prediction of Response to Therapy;prevent;Prognosis;public health relevance;Radical Cystectomy;Recurrence;Resistance;response;response biomarker;Serum;Signal Pathway;Signal Transduction;Specificity;Specimen;standard care;STAT3 gene;Testing;Tissues;Toxic effect;Transgenic Model;Translating;Treatment Failure;tumor;Tumor Cell Invasion;tumor growth;tumorigenesis;Up-Regulation;Urologic Cancer;Xenograft procedure

PROJECT_TITLE: Biomarker guided combinations for treating high-risk bladder cancer

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE The proposed project will develop and apply statistical models for estimating seasonal influenza disease burden, which are used for evaluating vaccine benefits, for communicating prevention and control messages, and for developing evidence-based policies for resource allocations.

PI_NAMEs: CHANG, HOWARD H (contact);CHEN, YONG

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 2019-nCoV;Adopted;Age;age group;age related;Algorithms;Anti-viral Agents;Attention;burden of illness;Cardiovascular system;Centers for Disease Control and Prevention (U.S.);Cessation of life;Cities;Collaborations;Communicable Diseases;Communication;Communities;Computer software;Data;data integration;Databases;Development;disease transmission;Economic Burden;Emergency department visit;Environmental Epidemiology;Epidemiology;Evaluation;Event;evidence base;flu activity;Future;Health;Health Personnel;Hospitalization;Immunization Programs;improved;Individual;Infection;Influenza;influenza surveillance;Influenza vaccination;influenzavirus;Infrastructure;interest;Knowledge;Laboratories;Location;low and middle-income countries;Measures;Methodology;Methods;Modeling;Morbidity - disease rate;novel;Outcome;pandemic disease;pandemic preparedness;Participant;Patients;Performance;Pneumonia;Policies;Population;Population Heterogeneity;Prevention;privacy preservation;Process;Proxy;Reporting;Residual state;Resource Allocation;Resources;respiratory;Respiratory Disease;respiratory health;respiratory morbidity;respiratory pathogen;Respiratory syncytial virus;Respiratory Tract Infections;seasonal influenza;Seasons;Series;sex;Site;Statistical Models;surveillance data;Symptoms;System;Testing;Time;tool;Uncertainty;United States;vaccine evaluation;World Health Organization

PROJECT_TITLE: Methods for Estimating Disease Burden of Seasonal Influenza

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


NIH_SPENDING_CATS: Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Herpes simplex virus type 1 (HSV-1) establishes a lifelong, silent infection in sensory neurons, and occasionally is reactivated to cause diseases that range in severity from benign cold sores to encephalitis. The proposed studies will determine the composition, mechanisms of biogenesis, and functions of extracellular vesicles released during HSV-1 infection. Alterations in the microenvironment of infection caused by these EVs could impact the infection and contribute to virus mediated pathogenesis.

PI_NAMEs: KALAMVOKI, MARIA  (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Afferent Neurons;Alzheimer's Disease;Benign;Biogenesis;Capsid Proteins;Cell Physiology;cell type;Cells;Communication;Complex;Cytosol;Data;design;Disease;DNA;Encephalitis;Endosomes;env Gene Products;Epithelial Cells;extracellular vesicles;Gene Expression;Gene Silencing;Glycoproteins;Herpes Labialis;Herpes Simplex Infections;Herpesvirus 1;HIV-1;Human;Immune Evasion;Immune response;in vivo;Infection;Innate Immune Response;insight;Integration Host Factors;intercellular communication;Light;Lytic Phase;Mass Spectrum Analysis;Mediating;Mucous Membrane;mutant;Names;Natural Immunity;Neurodegenerative Disorders;Neurons;particle;pathogen;Pathogenesis;Pathway interactions;Population;Primary Infection;Production;Productivity;Proteins;Reporting;response;Role;sensor;Sensory Ganglia;Severities;Sorting;Stimulator of Interferon Genes;Stress;Testing;vesicular release;Viral;Viral Genes;Viral Genome;Viral Proteins;Virion;Virus;Virus Replication;VP 16

PROJECT_TITLE: Cargo, biogenesis and functions of extracellular vesicles released during HSV-1 infection

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Prevention;Substance Misuse;Substance Misuse Prevention

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Despite the prevalence and cost alcohol use disorder (AUD), treatment strategies are ineffective, especially in preventing relapse. A key feature of AUD is that following long-term drinking, alcohol taking and seeking is motivated by the drive to avoid alcohol’s withdrawal symptoms. This proposal focuses on understanding how the brain controls the motivation to avoid the negative states induced by withdrawal and how we can use this understanding to prevent relapse.

PI_NAMEs: CALIPARI, ERIN  (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Abstinence;Acute;Address;Affective;affective disturbance;Alcohol consumption;alcohol cue;alcohol exposure;alcohol measurement;alcohol prevention;alcohol reinforcement;alcohol response;alcohol seeking behavior;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;AMPA Receptors;Amygdaloid structure;Animals;Aversive Stimulus;awake;Behavior;Behavioral;Brain;brain control;Brain region;cell type;Cells;Chronic;Consumption;cost;Cues;Data;Development;Disease;drinking;Drug usage;Electrophysiology (science);Endoscopy;feeding;Glutamates;Goals;in vivo;Individual;Inhalation;Learning;Link;maladaptive behavior;Maps;Marble;Measures;Modeling;motivated behavior;Motivation;Mus;negative affect;Negative Reinforcements;neural;neural circuit;Neurons;Nucleus Accumbens;Optics;optogenetics;patch clamp;Pattern;Physiological;Play;Population;Population Control;Positive Reinforcements;Prefrontal Cortex;Prevalence;prevent;Psychological reinforcement;Recording of previous events;reinforcer;relapse prevention;Research;Resolution;Role;Self Administration;Signal Transduction;Slice;System;Thalamic structure;treatment strategy;vapor;Withdrawal;Withdrawal Symptom;Work

PROJECT_TITLE: Circuit control of motivation to take and seek alcohol

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]