FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE The University of Massachusetts, Boston (UMass Boston) and Dana-Farber/Harvard Cancer Center (DF/HCC) Partnership is committed to further developing a shared rigorous and collaborative transdisciplinary cancer and disparities-related research program that is primed for “Bridging the Divides: Innovations to Address Gaps in Cancer Disparities Research, Education, Outreach and Infrastructure.” Sophisticated research projects are proposed across several areas of basic biomedical and population sciences that will employ evidence and methods to converge upon and impact cancer and cancer health disparities at multiple levels of analysis. These projects, together with state-of-the-art Outreach and Research Education Cores and creative Research Design and Analysis Core and Genomics Cores, will serve to build research capacity and infrastructure at UMass Boston, expand the cancer disparities platform and community outreach programs at DF/HCC; and make, at an elevated level, significant advances to the science of cancer control.

PI_NAMEs: ABEL, GREGORY ALAN;VISWANATH, KASISOMAYAJULA  (contact)

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: Absenteeism;Address;Advanced Malignant Neoplasm;anti-cancer research;Area;Biology;Boston;Cancer Center;Cancer Control;cancer health disparity;Cancer health equity;Cancer Science;career;career development;Charge;Color;Communities;community engagement;Community Networks;community organizations;Community Outreach;Creativeness;Data;Data Set;Dedications;Discipline;Disparity;dissemination science;Education;education research;Ethnic Origin;experience;Experimental Designs;experimental study;Faculty;Foundations;Funding;Genomics;Goals;Government;Grant;Health Disparities Research;implementation science;Incidence;Infrastructure;innovation;Institution;Joints;Lasers;Leadership;Malignant Neoplasms;Massachusetts;member;Mentors;Methods;Modeling;Morbidity - disease rate;mortality;outreach;outreach program;Phase;Population;Population Group;Population Heterogeneity;Population Sciences;Postdoctoral Fellow;programs;Race;Research;research and development;Research Design;Research Infrastructure;Research Personnel;Research Project Grants;research study;Resource Sharing;Resources;Science;socioeconomic disparity;Solid;Source;Students;Training;translational model;translational potential;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Universities

PROJECT_TITLE: 2/2 The University of Massachusetts, Boston - Dana-Farber/Harvard Cancer Center U54 Comprehensive Partnership for Cancer Disparities Research


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: ROCHESTER

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE/LAY SUMMARY Chronic kidney disease is a common diagnosis in the general community but also represents a concern in patients who undergo radical or partial nephrectomy for renal cancer. This research program will develop and employ deep learning algorithms to study macrostructural features of non-cancerous kidney tissue. The goals are to establish automated imaging biomarkers as tools that can aid clinicians in predicting the future development of chronic kidney disease and understanding their microstructural histology determinants (nephron hypertrophy and nephrosclerosis).

PI_NAMEs: DENIC, ALEKSANDAR  (contact);KLINE, TIMOTHY LEE

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: Abdomen;abdominal CT;Affect;Algorithms;Anatomy;Area;Arizona;Artificial Intelligence;automated segmentation;Biological Markers;Biometry;Biopsy;Characteristics;Chronic Kidney Failure;Clinic;Clinical;Clinical Data;clinical decision-making;cohort;Communities;comorbidity;Compensation;Complication;cone-beam computed tomography;Contralateral;Creatinine;Cyst;Data;Dedications;deep learning;deep learning algorithm;density;Development;Diagnosis;Disease Progression;Distant;Environment;Excision;Fibrosis;Florida;follow-up;Future;General Population;glomerulosclerosis;Goals;Growth;Histology;Hypertrophy;Image;image processing;imaging biomarker;implantation;improved;Individual;interstitial;Ischemia;Kidney;kidney biopsy;kidney cortex;Kidney Failure;kidney medulla;Long-Term Effects;machine learning model;Magnetic Resonance Imaging;Measures;Methods;Modeling;Modification;Nephrectomy;Nephrons;Nephrosclerosis;Normal tissue morphology;novel;Operative Surgical Procedures;Outcome;Patient Care;Patients;personalized decision;preservation;Prevalence;Principal Investigator;prognostic;prognostic tool;programs;radiological imaging;radiomics;Registries;Renal Carcinoma;Renal function;Research;Risk;Risk Factors;Scanning;Serum;Site;skills;Surface;Techniques;Texture;Tissues;tool;Training;tumor;Validation;Work;X-Ray Computed Tomography

PROJECT_TITLE: Artificial Intelligence-Based Methods to Characterize Kidney Macrostructure from Pre- and Post-Nephrectomy Computed Tomography Images

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: STANFORD

ORG_DEPT: NEUROSURGERY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: NARRATIVE – OVERALL COMPONENT The Stanford Brain Metastasis Consortium has unified brain and cancer experts in the singular goal of improving our understanding and treatment of brain metastases, a currently increasing yet underserved subset of cancer patients. To accomplish the above goal, we have developed highly innovative and complementary Projects to understand and disrupt the cancer-neuro-immune axis supporting brain metastases, and created Research Cores to make human specimens and cutting-edge technologies readily accessible to participating scientists. We expect to identify and target key mediators of brain metastasis, with therapeutic benefit for patients.

PI_NAMEs: HAYDEN GEPHART, MELANIE  (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: Address;Advocate;Biology;Brain;brain cell;Brain Neoplasms;Cancer Patient;Clinical;Clinical Trials;Communication;Communities;CRISPR library;Data;data management;Dedications;design;Deterioration;Development;Diagnostic;disease model;Ensure;Exclusion;experience;Experimental Models;Foundations;glycoproteomics;Goals;high throughput screening;Human;human disease;human tissue;Immune system;Immunotherapy;improved;In Vitro;in vivo Model;Incidence;innovation;insight;interest;Interruption;Malignant Neoplasms;Mediator;Metastatic malignant neoplasm to brain;Methods;Microglia;Modeling;Molecular;multidisciplinary;Mus;Neoplasm Metastasis;neoplastic cell;Neuroimmune;Neurologic;neuropathology;new therapeutic target;novel;Office of Administrative Management;organizational structure;Organoids;Patient risk;Patients;Physicians;Primary Neoplasm;Production;Productivity;programs;Quality of life;Research;Sampling;Scientist;Site;Specimen;synergism;Technology;Testing;Therapeutic;therapy resistant;tool;Translating;Translations;Tropism;tumor;tumor microenvironment;Tumor Tissue;Work

PROJECT_TITLE: Deconvolution and interruption of the cancer-neuro-immune axis facilitating brain metastases


ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative Metastatic breast cancer and relapse following therapy are dependent on (1) development of intrinsic resistance to targeted and endocrine therapies, and (2) resistance to recognition and destruction of cancer cells by the immune system. The Stanford Breast Metastasis Center (SBMC) is focused on (1) quantifying the timing of metastatic dissemination in breast cancer (2) functionally delineating the contribution of cellular and microenvironmental crosstalk on metastatic proclivity, and (3) characterizing the mechanisms of responses by metastatic cells to therapies. To achieve these goals, we harness an integrated systems biology, functional genomic and evolutionary dynamic approach applied to longitudinal breast cancer tissue cohorts and patient- derived organoid models.

PI_NAMEs: CURTIS, CHRISTINA N (contact)

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: 3-Dimensional;Address;bean;biobank;Biological Models;Breast;breast cancer metastasis;Breast Cancer Model;Breast Cancer Patient;breast cancer progression;cancer cell;Cancer Relapse;Cell Communication;Cells;Classification;Clinical;cohort;Collection;computer framework;Computer Models;computerized tools;CRISPR screen;CRISPR/Cas technology;Data;data integration;Dependence;Development;Diagnosis;Disease;disease heterogeneity;ERBB2 gene;Estrogen receptor positive;Experimental Models;functional genomics;genome-wide;Genomic approach;Genomics;Goals;high risk;hormone therapy;Image;Immune;Immune system;In Situ;innovation;invention;Lead;Longitudinal cohort;Machine Learning;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Metastatic breast cancer;Modeling;Molecular;Molecular Profiling;multidisciplinary;Multiplexed Ion Beam Imaging;Nature;Neoplasm Metastasis;neoplastic cell;Non-linear Models;Oncogenic;Organoids;Outcome;Pathologist;Pathology;Patients;Phagocytosis;Population;Primary Neoplasm;Process;Property;prospective;Relapse;relapse risk;Research Project Grants;Research Support;Resistance;Resolution;Resource Sharing;response;Sampling;single cell technology;Site;Spatial Distribution;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Stromal Cells;Subgroup;System;Systems Biology;targeted treatment;Technology;Therapeutic;therapeutic target;therapy resistant;Time;Tissue Model;tissue resource;Tissue Sample;Tissues;triple-negative invasive breast carcinoma;tumor;Tumor Tissue;Vision;Visualization

PROJECT_TITLE: Evolutionary dynamics and microenvironmental determinants of metastatic breast cancer


ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE Overall Section  This proposal focuses on elucidating the genomic and microenvironmental determinants, and temporal dynamics underlying efficacy of radiation-based combination therapies. We will use an innovative molecular characterization trial testing radiation plus antibody-drug conjugate in bladder cancer and radiation plus immunotherapy in head and neck cancer to characterize the mechanistic drivers underlying these next generation RT-based therapies. Our studies will help build a foundation to optimize multimodal, radiation- based definitive treatment strategies.

PI_NAMEs: CHAN, TIMOTHY AN-THY (contact);YU, DAVID SUNG-WEN

PROGRAM_OFFICER_NAME: VIKRAM, BHADRASAIN

PROJECT_TERMS: Antibody-drug conjugates;antitumor effect;Automobile Driving;Biography;Biological Markers;Biological Products;Bladder;Breast Cancer Patient;Cancer Patient;cancer therapy;cancer type;checkpoint therapy;chemotherapy;Chemotherapy and/or radiation;Cisplatin;Clinic;Clinical;Combined Modality Therapy;Data;Disease;DNA Damage;Event;Foundations;Gene Expression;Genetic;Genetic Transcription;Genomics;Goals;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Head and neck structure;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immune system;Immunologic Factors;Immunologics;Immunotherapy;improved;improved outcome;innovation;insight;International;Malignant neoplasm of urinary bladder;Modality;Molecular;multidisciplinary;multimodality;Mutation;next generation;Oncology;Outcome;Pathogenesis;Patients;preservation;programs;Radiation;radiation effect;radiation resistance;radiation response;Radiation therapy;Radiation Tolerance;Radiobiology;radiomics;Research;Research Personnel;Resistance;response;Robin bird;Roentgen Rays;standard of care;Testing;Therapeutic;Treatment Efficacy;treatment strategy;tumor;Work

PROJECT_TITLE: Genomic and Microenvironmental Determinants, Temporal Dynamics, and Treatment Efficacy of Radiation-Based Combination Therapies


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hematology;Neuroblastoma;Neurosciences;Orphan Drug;Patient Safety;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: OAKLAND

ORG_NAME: PUBLIC HEALTH INSTITUTE

PHR: Project Narrative The Children’s Oncology Group (COG) is the world’s largest organization devoted exclusively to childhood and adolescent cancer research with more than 9,000 members at over 220 leading children’s hospitals, universities, and cancer centers across the U.S., Canada and other countries. The COG conducts therapeutic trials as well as cancer control and cancer care delivery research studies to improve outcomes across diverse populations including adolescents and young adults with cancer.

PI_NAMEs: POLLOCK, BRAD H;ROTH, MICHAEL E. (contact)

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: Acute;Acute Myelocytic Leukemia;Address;Adolescent;Adolescent and Young Adult;Adolescent and young adult cancer patients;Adult;Aftercare;Age;anti-cancer research;base;Brain Stem Glioma;Canada;cancer care;Cancer Center;Cancer Control;cancer therapy;care delivery;Caring;Characteristics;Child;Childhood;childhood cancer survivor;Clinical Medicine;Clinical Research;Clinical Trials;Collaborations;Communities;Community Clinical Oncology Program;Community Participation;Complication;Country;data management;data quality;design;Disadvantaged;Disease;disparity elimination;Dose;effective therapy;Ensure;experience;follow-up;Functional disorder;Goals;Grant;Group Affiliation;health care delivery;health care service organization;Health Disparities Research;health disparity;health related quality of life;high risk;Hormonal;improved;improved outcome;Infant;Information Technology;Infrastructure;Institution;Interdisciplinary Study;Intervention;Laboratory Research;Late Effects;Leadership;long-term sequelae;Malignant Childhood Neoplasm;Malignant Neoplasms;member;Minority;minority disparity;Mission;Monitor;Morbidity - disease rate;mortality;Neuroblastoma;novel;optimal treatments;Organ;Outcome;outcome disparities;Pathology;Patients;Pediatric Hospitals;Pediatric Oncology;Pediatric Oncology Group;Persons;Population Heterogeneity;Positioning Attribute;prevent;Prevention;Prevention strategy;Prognosis;programs;Radiation Oncology;reproductive;Research;Research Personnel;research study;Resources;Second Primary Cancers;side effect;Site;Surgical Oncology;Survival Rate;survivorship;Symptoms;System;Therapeutic;Therapeutic Trials;Tissues;Translating;Treatment-related toxicity;underserved community;Underserved Population;Universities;Work;young adult

PROJECT_TITLE: Children's Oncology Group NCI Community Oncology Research Program (NCORP) Research Base grant


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Dissemination and Implementation Research;Health Services;Physical Rehabilitation;Rehabilitation

ORG_CITY: Aurora

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Patients experience dramatic quadriceps strength loss after total knee replacement, which contributes to persistent weakness and reduced long-term function after surgery. Neuromuscular electrical stimulation reduces quadriceps weakness and improves patient function after knee replacement, but it is drastically underused in rehabilitation practice. This randomized trial will examine the effectiveness and feasibility of a comprehensive strategy for implementing neuromuscular electrical stimulation after knee replacement in two large healthcare organizations.

PI_NAMEs: STEVENS-LAPSLEY, JENNIFER E. (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: Acute;Address;Adherence;Adopted;Adoption;Age;American;anterior cruciate ligament reconstruction;Atrophic;Attenuated;attenuation;Cardiac Surgery procedures;Characteristics;Clinic;Clinical;clinical practice;Clinical Practice Guideline;Cluster randomized trial;contextual factors;Data;disability;Disease;Early Intervention;Effectiveness;effectiveness evaluation;Eligibility Determination;Equilibrium;experience;fall risk;Focus Groups;functional improvement;Future;Gait speed;Health;health care service organization;Healthcare Systems;Hybrids;Impairment;implementation strategy;implementation tool;implementation/effectiveness;improved;improved outcome;Individual;information gathering;innovation;Intensive Care Units;Intervention;Investigation;Knee;Knee Osteoarthritis;knee replacement arthroplasty;Long term disability;Maintenance;Methods;multiple data sources;Muscle;muscle strength;Muscular Atrophy;Musculoskeletal;neuromuscular stimulation;older adult;Operative Surgical Procedures;Orthopedic Procedures;Outcome;Outpatients;pain reduction;Patient Self-Report;Patients;peer;Performance;Physical Function;Physical therapy;Postoperative Care;Practice Guidelines;Predictive Factor;primary endpoint;primary outcome;Process;quadriceps muscle;Quality of life;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Recovery of Function;Rehabilitation Outcome;Rehabilitation therapy;Reporting;Skeletal Muscle;success;Surveys;time use;Translations;Trauma;treatment as usual;United States;uptake;Variant

PROJECT_TITLE: Implementation of Neuromuscular Electrical Stimulation after Total Knee Arthroplasty

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Diabetes;Neurosciences;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

PHR: PROJECT NARRATIVE This proposal investigates whether enhancement in insulin action by six months of either high-intensity aerobic and resistance exercise training improves various measures of brain functions and brain-muscle connections, potentially explaining the improvement of cognition in people with insulin resistance. Insulin resistance is a condition in diabetes, obesity, and aging where insulin action is low and is associated with significantly higher prevalence of Alzheimer’s disease and other dementias. These studies based on high-technology brain imaging and functional measurements in combination with cognitive function are anticipated to reveal novel insights on how exercise training prevents dementia in people with insulin resistance.

PI_NAMEs: NAIR, K SREEKUMARAN  (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Accounting;Aerobic;Aerobic Exercise;Affect;aged;Aging;Alzheimer's Disease;Brain;Brain imaging;brain metabolism;Brain region;brain volume;Central Nervous System;Clinical Trials;Cognition;Cognitive;cognitive function;cohort;computerized;Data;Dementia;deprivation;Diabetes Mellitus;Electromyography;Ensure;executive function;Exercise;exercise intensity;Exercise Therapy;exercise training;experience;fluorodeoxyglucose;Functional Magnetic Resonance Imaging;Glucose Clamp;glucose uptake;Grant;High Prevalence;Hippocampus;Histology;Human;human data;human very old age (85+);Hyperinsulinism;Hypertrophy;Impairment;improved;insight;Insulin;Insulin deficiency;Insulin Receptor;Insulin Resistance;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;Interval training;Literature;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measurement;Measures;Memory;Mitochondria;mode of exercise;Molecular;Morphology;Motor Neurons;Mus;Muscle;muscle form;Muscle function;muscle hypertrophy;muscle strength;Muscular Atrophy;neural;neuroadaptation;Neurologic;neuromuscular;Neuromuscular Junction;Neurons;Non-Insulin-Dependent Diabetes Mellitus;Nose;novel;novel therapeutic intervention;Obesity;Observational Study;Older Population;Outcome;Output;Oxidative Phosphorylation;Oxidative Stress;Participant;Peripheral;Persons;Phosphorus;Positron-Emission Tomography;pre-clinical;prevent;Primates;Production;Proteins;Randomized;Records;Regulation;Reporting;Research Personnel;resistance exercise;resistance mechanism;response;Rest;Risk;Role;Route;sedentary;sensory cortex;Short-Term Memory;Skeletal Muscle;Spinal;Spinal Cord;System;Technology;Testing;Training Programs;Transcranial magnetic stimulation;United States National Institutes of Health;Walking

PROJECT_TITLE: Molecular Mechanisms of  Exercise Benefits to Insulin Resistant People

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Data Science;Genetics;Human Genome

ORG_CITY: LA JOLLA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative The human reference pangenome, which represents a collection of genome sequences in a single data structure, has the potential to transform human genetics applications. Here we will develop a web-based pangenome browser and a suite of command line tools to enable integrating existing pangenomes with other data sources including large biobanks for complex traits analysis and other applications. All software will be made widely available to accelerate the use of pangenomes by the research community.

PI_NAMEs: GYMREK, MELISSA  (contact)

PROGRAM_OFFICER_NAME: DAYAL, JYOTI

PROJECT_TERMS: Acceleration;biobank;Bioinformatics;Cactaceae;cohort;Collection;Communities;complement resource;Complex;complex data;computer infrastructure;Computer software;Consumption;Custom;Data;Data Set;Data Sources;data structure;data visualization;design;Detection;Ecosystem;experience;file format;Genes;Genetic;Genetic Polymorphism;Genetic Variation;Genome;genome analysis;genome sequencing;genome wide association study;genomic locus;Genomic Segment;Genomics;Genotype;Goals;Graph;Haplotypes;Human;Human Genetics;improved;Individual;interactive visualization;interest;large datasets;Location;Maps;Medical;Medical Genetics;Methods;novel;Online Systems;pan-genome;Pathogenicity;Performance;Phenotype;phenotypic data;Population;Process;reference genome;Research;Resources;Sampling;sex;Signal Transduction;Specificity;statistics;Structure;Technology;Testing;Time;tool;tool development;trait;Variant;Visualization;Visualization software;web app;whole genome

PROJECT_TITLE: Integrating the reference pangenome with biobank-scale data for complex trait analysis

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-M (M2)]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cancer;Clinical Research;Data Science;Electronic Nicotine Delivery Systems;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Tobacco;Tobacco Smoke and Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE Title: Artificial Intelligence for effective communication to promote vaping cessation on social media The proposed study will identify key features of e-cigarette-related social media (Twitter/X, Instagram, TikTok, and YouTube) posts associated with high user engagement (such as the number of likes) by leveraging cutting- edge artificial intelligence, including but not limited to natural language processing techniques and deep learning models, along with advanced statistical modeling techniques. Furthermore, we will conduct cross-sectional anonymous online surveys and semi-structured interview studies to verify the key features contributing to high user engagement and, more importantly, identify features targeting specific populations. The identified key features will be valuable for designing multimedia messages (text, image, and video) that effectively promote vaping cessation, especially among youth, young adults, and other disadvantaged groups.

PI_NAMEs: LI, DONGMEI  (contact)

PROGRAM_OFFICER_NAME: ILES, IRINA ALEXANDRA

PROJECT_TERMS: addiction;Affect;aged;Algorithms;Artificial Intelligence;Attitude;authority;Behavior;Belief;biopsychosocial;Breathing;Categories;combustible cigarette;Communication;Communities;community advisory board;Data;data resource;Data Sources;deep learning algorithm;deep learning model;design;Disparity population;Electronic cigarette;electronic cigarette use;electronic cigarette user;Epidemic;Ethnic Origin;experience;Exposure to;feature selection;Future;Geography;Goals;Health;Health Campaign;High School Student;Image;Industry;innovation;Instagram;Interview;Language;large language model;Machine Learning;Marketing;Measures;Methodology;Methods;Middle School Student;Modeling;Multimedia;Natural Language Processing;Nicotine Dependence;novel;Participant;Perception;Persuasive Communication;Policies;Population;Population Heterogeneity;Prevalence;prevent;Prevention;Public Health;Published Comment;Race;Reporting;Research;Risk;Sales;Smoking;smoking cessation;social media;Statistical Models;Structure;Surveys;Techniques;Text;TikTok;Time;Tobacco;Tobacco 21 policies;tobacco products;Tobacco use;Training;Twitter;United States;United States Food and Drug Administration;uptake;Validation;vaping;Variant;young adult;Youth

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Obesity;Prevention

ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

ORG_STATE: NH

PHR: PROJECT NARRATIVE The proposed study will leverage a national network of implementation sites to identify key factors that influence long-term sustainment of an evidence-based health promotion intervention in mental health organizations. We will build on these findings to develop, iteratively evaluate, and refine a sustainment practice guide for future research and practice.

PI_NAMEs: ASCHBRENNER, KELLY A (contact);BARTELS, STEPHEN J

PROGRAM_OFFICER_NAME: LUSHIN, VICTOR

PROJECT_TERMS: Address;Adult;Antipsychotic Agents;Behavioral;Body Weight decreased;cardiorespiratory fitness;cardiovascular risk factor;Characteristics;Clinical;clinically significant;Collaborations;Communities;Community of Practice;contextual factors;Data;Disabling;Disease;Drops;Educational workshop;effectiveness/implementation study;Evaluation;evidence base;Evidence based intervention;experience;Failure;Funding;Health;Health behavior;Health Benefit;health disparity;Health Promotion;Health Sciences;implementation research;implementation science;implementation study;improved;Individual;innovation;Intervention;Investigation;Investments;Life Expectancy;lifestyle intervention;Measurement;Measures;Mental disorders;Mental Health;mental health organization;meter;Methods;Mission;model building;Morbidity - disease rate;mortality;National Institute of Mental Health;Obesity;Outcome;Participant;participant enrollment;Persons;Pharmaceutical Preparations;Population;post implementation;Predictive Factor;Process;Program Sustainability;programs;Public Health;Research;Research Project Grants;Risk Reduction;severe mental illness;Site;stem;sustainability framework;System;Testing;Training;translational study;two-dimensional;voltage;Walking

PROJECT_TITLE: Dynamic Sustainment of Evidence-Based Health Promotion Interventions in Mental Health

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Diabetes;Genetics;Human Genome;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PROJECT NARRATIVE Abnormal placental development in pregnant individuals with obesity and diabetes contributes to miscarriage, preeclampsia, and stillbirth that are all major public health concerns. This study will determine how glucose and glutamine signaling in mitochondria regulate placental development. Defining how nutrient availability affects placental health will inform novel strategies for improving outcomes in pregnancies complicated by obesity and diabetes.

PI_NAMEs: WERNIMONT, SARAH A (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Acetyl Coenzyme A;Acetylation;Address;adverse pregnancy outcome;Affect;alpha ketoglutarate;Biochemical;cellular development;citrate carrier;Citrates;cofactor;comorbidity;Compensation;CRISPR/Cas technology;cytotrophoblast;Data Set;demethylation;Diabetes Mellitus;Epigenetic Process;epigenetic regulation;Event;evidence base;experimental study;Fetal health;Foundations;Gases;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;Genes;Genetic;genome-wide;Glucose;Glutaminase;Glutamine;Health;High Pressure Liquid Chromatography;Histone Acetylation;Histone H3;histone methylation;Histones;Hormones;Human;Impairment;improved;improved outcome;indexing;Individual;inhibitor;Isocitrate Dehydrogenase;Knock-out;Knowledge;Lead;Link;liquid chromatography mass spectrometry;loss of function;maternal diabetes;maternal obesity;Measures;Metabolic;Metabolism;metabolomics;Methodology;Methylation;Mitochondria;Modification;Morphology;novel;novel strategies;Nutrient;Nutrient availability;Obesity;obesity in pregnancy;Outcome;overexpression;Overnutrition;Pathway interactions;Placenta;Placentation;Play;Pre-Eclampsia;Pregnancy;Pregnancy Complications;Pregnancy Outcome;pregnant;Process;Production;Proteins;Public Health;Pyruvate;pyruvate carrier;Regulation;Repression;Role;Signal Transduction;Source;Spirometry;Spontaneous abortion;stable isotope;stem cell model;stillbirth;Syncytiotrophoblast;Testing;tool;transcriptional reprogramming;transcriptome sequencing;transcriptomics;trophoblast;trophoblast stem cell;women's outcomes;Work

PROJECT_TITLE: Mitochondrial nutrient transport and trophoblast differentiation

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Climate-Related Exposures and Conditions;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

PHR: Two major risk factors for Alzheimer’s disease are elevated brain Fe levels and low socioeconomic status (SES) communities experiencing uncontrollable, poverty-associated stressors. Air pollution, and associated Fe contamination, are higher in low SES communities, subjecting these populations to two major risk factors for cognitive decline. The current grant proposes to evaluate the effects of inhaled Fe, at different concentrations and in stress vs. resilience-inducing contexts, to advance our mechanistic understanding of how co-occurring environmental stressors, with shared biological consequences, can converge to enhance or mitigate risk for memory loss and Alzheimer’s Disease.

PI_NAMEs: TERRY, MARISSA SOBOLEWSKI (contact)

PROGRAM_OFFICER_NAME: DHRUV, NEEL TUSHAR

PROJECT_TERMS: Acceleration;Adult;air contaminant;Air Pollution;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease risk;Astrocytes;astrogliosis;Behavior Therapy;Behavioral;behavioral outcome;Biological;Blood - brain barrier anatomy;Brain;brain iron;Brain region;Caring;Characteristics;Communities;Complex Mixtures;Corpora amylacea;Data;Dementia;dementia risk;Deposition;design;Development;Diameter;Discrimination;disease phenotype;Disproportionately impacts women;Elderly;Elements;Environment;environmental enrichment for laboratory animals;environmental stressor;Epidemiology;experience;experimental study;Exposure to;Female;fine particles;Food;frontal lobe;Gases;Glutamates;Grant;health disparity;Health Policy;Hippocampus;Homeostasis;Housing;Impaired cognition;improved;Income;Inhalation;Iron;iron metabolism;Iron Overload;iron oxide;Lead;life span;Link;Lipid Peroxidation;low socioeconomic status;magnetite ferrosoferric oxide;Measures;Mediating;Medical;Memory;Memory impairment;Memory Loss;Metals;meter;Microglia;mild cognitive impairment;mouse model;Mus;nanoparticle;Neighborhoods;Nerve Degeneration;neurobiological mechanism;neuroinflammation;neuron loss;Neurons;neuropathology;neurotoxicity;olfactory bulb;Outcome;Oxidation-Reduction;Oxidative Stress;particle;Particulate;perceived stress;Peripheral;Phenotype;Play;pollutant;Population;Poverty;prevent;Prevention;processing speed;Proteins;Psychological Stress;Psychosocial Stress;psychosocial stressors;Public Health;Quality of life;Reporting;Research;resilience;Risk;Risk Factors;risk mitigation;Role;scaffold;segregation;Senile Plaques;Sex Bias;Socioeconomic Status;Source;Stress;Stressful Event;stressor;Subway;System;tau Proteins;tau-1;Testing;Time;Toxic effect;Trace Elements;ultrafine particle;Unemployment;white matter damage;Work

PROJECT_TITLE: Air Pollution-Derived Iron Exposure, Poverty-Related Stress, and Alzheimer's Disease Risk

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-K (55)]


NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: CHEMISTRY

PHR: Project Narrative: The copper oxygenases and oxidases play key roles in natural product biosynthesis1, 2, neurotransmitter3, 4, and neuropeptide hormone regulation5, 6, iron metabolism7, 8, and biological energy transduction.9-11 Experimentally elucidating their actual mechanisms and how Nature controls their reactivities is both of fundamental importance and has downstream applications in controlling neurological disorders12-15, understanding melanogenesis in human diseases and agricultural applications16-18, the design of new biocatalysts19, 20, and second sphere control into homogenous21, 22 and heterogenous catalysts23-25, and in the development of new biofuel cells26, 27, including wearable devices.28

PI_NAMEs: SOLOMON, EDWARD I (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: absorption;Active Sites;Address;Agriculture;Aminophenols;Anabolism;analog;ascorbate;ATP Synthesis Pathway;Binding;Biological;Biotechnology;Catalysis;catalyst;Catechols;Cells;Ceruloplasmin;Chemicals;circular magnetic dichroism;Complex;Copper;copper oxidase;Coupled;Coupling;crosslink;design;Development;Dopamine;Dopamine-beta-monooxygenase;Electrodes;Electron Transport;electronic structure;Electrons;emission spectroscopy;Enzyme Kinetics;enzyme mechanism;Enzymes;experimental study;Health;health application;Heme;heme a;Homologous Gene;hormone regulation;Human;human disease;Hydrogen;Hydrogen Bonding;Hydroxylation;inhibitor;Insecta;insight;Ions;iron metabolism;Kinetics;Ligands;magnetic field;Magnetism;Melanins;Melanogenesis;Membrane;Methionine;Methodology;Methods;Mixed Function Oxygenases;Modeling;Molecular;Molecular Conformation;Monophenol Monooxygenase;Natural Products;Nature;Nervous System Disorder;Neuropeptides;Neurotransmitters;Norepinephrine;Nuclear;Oxidases;oxidation;Oxidation-Reduction;Oxygenases;peptidylglycine alpha-amidating monooxygenase;Pharmaceutical Preparations;Phenols;Play;Proton Pump;protonation;Protons;Pump;Quinones;Reaction;Reactive Oxygen Species;Regulation;Research;Rest;Roentgen Rays;Role;Siderophores;Site;Spectrum Analysis;Structure;Techniques;Temperature;Test Result;Tyramine;ubiquinol oxidase;Variant;wearable device

PROJECT_TITLE: Mechanistic Intermediates in Copper Oxygenases and Oxidases

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Despite there being ~294,000 individuals with SCI nationwide and ~17,810 new cases each year, we still lack an effective therapeutic that can significantly restore functions that are lost. This study addresses the urgent need to develop SCI therapeutics by further exploring and optimizing a promising and new potential treatment strategy called optogenetic spinal stimulation. By adjusting the number of stimulation sessions, combining stimulation with an axon growth-enhancing peptide, and assessing the resulting circuitry changes, we will be critical-steps closer to a treatment for spinal injuries of varying magnitudes.

PI_NAMEs: MONDELLO, SARAH E. (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Address;Affect;axon growth;Behavioral;Binding;Calcium;cell type;Cervical;Cervical spinal cord injury;Cervical spine;Chondroitin Sulfate Proteoglycan;Chronic;cohort;Color;combinatorial;Communities;Contralateral;density;Development;Dose;effective therapy;Electric Stimulation;Electrophysiology (science);Fluorescence;Forelimb;functional restoration;Future;Genetic;Goals;Histologic;Hour;Immunohistochemistry;improved;Individual;Injury;injury recovery;insight;Investigation;Learning;Lesion;Methods;Modification;Muscle;Neuromodulator;Neuronal Plasticity;Neurons;neuroregulation;Neurostimulation procedures of spinal cord tissue;novel;optogenetics;Paralysed;Peptides;Proteoglycan;Quality of life;Rattus;receptor;Recovery;Recovery of Function;Research;response;severe injury;Site;Spinal;Spinal Cord;Spinal Cord Contusions;Spinal cord injury;Spinal Injuries;Synapses;Testing;Therapeutic;therapeutic effectiveness;therapeutically effective;Tissues;tool;Translating;treatment strategy;Ultraviolet Rays;vector;Viral Vector;Work

PROJECT_TITLE: Stimulation-based strategies for forming new lesion-bridging circuitry and optimizing functional recovery after spinal cord injury

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative The ARTEMIS project will establish an advisory panel to engage individuals who have lived experience with polysubstance drug use and reside in rural communities, a markedly under resourced and high-risk focal population. The team will utilize and leverage patient insights to help identify and address barriers to treatment as well as gaps in systems of service delivery to improve access and engagement. This panel will serve as a resource to support providers and researchers in integrating patient perspectives with the treatment and study of substance use disorders.

PI_NAMEs: KATTAKUZHY, SARAH M. (contact);MAGIDSON, JESSICA F

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: Acceleration;addiction;Address;Advisory Committees;Advocate;Awareness;Baltimore;barrier to care;Buprenorphine;care delivery;Caring;Cessation of life;Clinical;Clinical Research;Clinical Services;Clinical Treatment;community academic partnership;community advisory board;community collaboration;Compensation;Consultations;design;Drug usage;Employment;Ensure;ethnographic method;experience;Feedback;functional improvement;Funding;Health;Health Services Accessibility;Helping to End Addiction Long-term;high risk;Improve Access;improved;Individual;Infrastructure;innovation;insight;integrated care;Intervention;Interview;Lead;Lived experience;Maryland;Medicine;meetings;methadone treatment;Modeling;neglect;novel;novel strategies;Outcomes Research;Overdose;overdose risk;Participant;patient engagement;patient oriented;Patient-Centered Care;Patient-Focused Outcomes;Patients;Pattern;peer;peer recovery;Pilot Projects;polysubstance use;Population;preference;Process;Provider;Qualitative Research;Recording of previous events;recovery services;recruit;Research;research and development;Research Design;Research Personnel;Research Project Grants;Research Proposals;Resources;Rural;rural area;Rural Community;rural counties;Rural Health;rural patients;service delivery;Service delivery model;Services;Site;social health determinants;Stimulant;substance use;Substance Use Disorder;System;Telemedicine;Transportation;Treatment outcome;treatment program;Universities;Voice;Work

PROJECT_TITLE: ARTEMIS: Advancing Addiction Research and Treatment through Engagement with Rural Marylanders Impacted by PolySubstance Use

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SAI-E (M1)]


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biotechnology;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative The goal of this project is to assess the role of cost-associated barriers to new and future novel AD/ADRD therapeutics in Hispanic or Latino people. To do this, we will engage both a cohort of Latino adults created as part of the team’s ongoing work on diversity in clinical trials and an existing group of Latino patients with AD/ADRD and their caregivers. Our work in the first (planning) phase of the project will include semi-structured interviews and a population-based survey to understand knowledge of and barriers to new novel AD therapeutics. The second stage of our work will analyze existing Medicare claims and Encounter data to understand actual use patterns. We will then use the team’s well-established dynamic microsimulation to estimate the downstream impacts of use on cognitive and physical health, costs, and quality of life of older Hispanic or Latino adults with dementia.

PI_NAMEs: JACOBSON, MIREILLE  (contact);MOLINA-HENRY, DORIS PATRICIA

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Acceleration;Aducanumab;Adult;Affect;Alzheimer's disease model;Alzheimer's disease related dementia;American;Amyloid beta-Protein;Asian;Behavioral;beneficiary;Biological Factors;Black race;California;Caregiver support;Caregivers;Central America;Clinical;Clinical Trials;Cognitive;cohort;cost;cost comparison;Data;Dementia;Dependence;deprivation;design;Development;Diabetes Mellitus;disability;Disadvantaged;Disease;Disparity population;Drug Utilization;economic impact;Educational Status;Equity;ethnic disparity;Ethnic Origin;experience;Family;Family Caregiver;Funding;Future;Glaucoma;Goals;health disparity;Health Expenditures;High Prevalence;Hispanic;Hispanic Populations;Hypertension;Impaired cognition;Incidence;Individual;Infusion procedures;Interview;Knowledge;Latino;Latino Population;Learning;Longitudinal cohort study;Low income;Marketing;Medical;Medicare;Medicare claim;medication compliance;medication nonadherence;Mexico;models and simulation;Monoclonal Antibodies;Native-Born;Neighborhoods;Not Hispanic or Latino;novel;novel therapeutics;older adult;Patients;Pattern;Persons;Pharmaceutical Preparations;Phase;physical conditioning;population based;Prevalence;Process;Quality of life;Race;racial disparity;racial diversity;randomized trial;Reporting;Research;Research Personnel;Risk;Role;Severity of illness;side effect;simulation;social culture;Social Impacts;Socioeconomic Factors;Structure;Surveys;System;Therapeutic;Time;Trust;Universities;willingness to pay;Work

PROJECT_TITLE: Cost and Non-Cost Barriers to Use of Novel AD Therapeutics among Older Hispanic or Latino Adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-9 (M4)]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Prevention;Rehabilitation

ORG_CITY: GAINESVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Public Health Relevance The proposed experiments will determine the neural mechanisms of gait and cognitive-motor interactions in individuals with subjective cognitive decline. Gait speed slows in this population before cognitive declines appear; therefore, a greater understanding of how neural control of walking differs in subjective cognitive decline relative to typical aging will lead to new interventions and early biomarkers for impending declines.

PI_NAMEs: SEIDLER, RACHAEL D (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Address;Age;age difference;age related;age related decline;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid beta-42;Amyloid beta-Protein;apolipoprotein E-4;Area;Atrophic;Behavior;Bilateral;Biological Markers;Blood;Brain;brain behavior;Brain region;Brain Stem;Cerebellum;Cognition;Cognitive;cost;Coupled;Data;early detection biomarkers;Early Intervention;Electroencephalography;Engineering;Equilibrium;experimental study;falls;Family history of;Functional Magnetic Resonance Imaging;Gait;Gait speed;Genetic Polymorphism;Genotype;gray matter;Health;high risk;Hippocampus;Impaired cognition;Impairment;Individual;insight;Intervention;Knowledge;Link;Magnetic Resonance Imaging;Mediating;mild cognitive impairment;Mobility decline;Mobility disability;Motor;Motor Cortex;neural correlate;neuromechanism;neuroregulation;Neurosciences;novel;older adult;Older Population;Performance;Play;Population;public health relevance;Receptors, Adrenergic, alpha-2;Request for Applications;Rest;segregation;Structure;tau Proteins;tau-1;Temporal Lobe;Testing;Thick;Thinking;Thinness;transcranial direct current stimulation;Vestibular function;vestibular system;virtual;Walking;way finding;Work

PROJECT_TITLE: Neural Correlates of Cognitive-Motor Interactions in ADRD Gait

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-G (M1)]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Childhood Injury;Clinical Research;Genetics;Infant Mortality;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Stroke;Unintentional Childhood Injury

ORG_CITY: DURHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative: Intratelencephalic (IT) neurons are thought to underlie human cognition and show specific disruption in neurodevelopmental disorders; however, little is known about the genetics and axon projection patterns of different IT neuron subtypes and their alterations in disease. This proposal seeks to utilize novel genetic mouse lines, axon tracing techniques, and cutting-edge transcriptomic profiling to understand the changes in gene expression and axon projections of two specific IT neuron subtypes after perinatal hypoxic ischemic encephalopathy (HIE), a common brain injury in term babies that results in neurodevelopmental symptoms. These experiments will help us understand the detailed pathology of HIE in the brain and generate candidate targets for future cell-specific therapies to precisely ameliorate the developmental symptoms of HIE.

PI_NAMEs: RUSS, JEFFREY B (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Affect;autism spectrum disorder;Axon;Bilateral;Biological Assay;Brain;Brain Injuries;career;Cell Nucleus;cell type;Cells;Cerebral cortex;Cerebral Palsy;Cognition;Cognition Disorders;Cognitive;cognitive ability;comparison control;Corpus striatum structure;Data;Detection;Development;Disease;early onset;Evolution;excitatory neuron;Exhibits;experimental study;Functional disorder;Future;Gene Expression;gene regulatory network;Genes;Genetic;Genetic Transcription;Global Change;Goals;Human;Impaired cognition;Infant;Informatics;innovation;Ipsilateral;Knock-in Mouse;Label;Mediating;Minor;Modeling;Molecular;Motor;Motor Cortex;motor disorder;motor impairment;motor symptom;Mus;natural hypothermia;neonatal hypoxic-ischemic brain injury;neonate;Nervous System Disorder;Neurobehavioral Manifestations;Neurocognitive;Neurodevelopmental Disorder;Neurons;novel;Outcome;Output;Pathology;Pathway interactions;Pattern;Perinatal anoxic ischemic brain injury;Precision therapeutics;prevent;Regulation;Reporter;Research;Resolution;response;single nucleus RNA-sequencing;Speech Delay;Structure;Symptoms;Syndrome;System;targeted treatment;Techniques;Testing;Tissue-Specific Gene Expression;tool;transcriptomic profiling;transcriptomics;translational physician;Viral;WFS1 gene;Work

PROJECT_TITLE: Discovering the cell type basis of the IT projection system and its dysregulation after perinatal HIE

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Opioid Misuse and Addiction;Opioids;Precision Medicine;Sleep Research;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative The proposed research is relevant for public health as it evaluates the mechanisms underlying opioid use dis- order treatment benefit while also testing a novel pharmacological treatment for insomnia, a common comor- bidity among individuals receiving addiction treatment. The goal of this project is to take critical initial steps to uncover the neurofunctional mechanisms engaged by the orexin system in the brain that regulates sleep, re- ward and stress responses. Project findings will advance the development of novel therapeutics in the ongoing overdose crisis for individuals seeking recovery from opioid use disorder.

PI_NAMEs: MARTIN, CAITLIN EILEEN (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: actigraphy;addiction;Adult;Advanced Development;Affect;Affinity;Animal Model;Animals;antagonist;Anxiety;associated symptom;behavior measurement;Behavior Therapy;Behavioral;biological adaptation to stress;biopsychosocial;biopsychosocial factor;Brain;Buprenorphine;Cause of Death;Clinical;clinical investigation;clinical trial participant;Clinical Trials;combat;Comorbid Insomnia;comorbidity;Coupled;craving;Data;Development;Dimensions;discounting;disease model;disparities in morbidity;distress tolerance;Drug Use Disorder;Emotional;Ensure;Ethnic Origin;FDA approved;Female;follow-up;Gender;Goals;health equity;Homeostasis;hypocretin;improved;improvement on sleep;Impulsivity;indexing;Individual;individualized medicine;innovation;Intervention;Investigation;Learning;Life;male;Measures;medication for opioid use disorder;Mental Depression;metacognition;Methods;mortality;Motivation;National Institute of Drug Abuse;novel;novel therapeutics;Opioid;opioid use disorder;Outcome;Outpatients;Overdose;overdose risk;Pain;Participant;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Phase;phase 1 study;Phenotype;Placebos;Play;pre-clinical research;precision medicine;preclinical study;prescription opioid;primary outcome;Procedures;Provider;Public Health;Race;receptor;Recovery;relapse prevention;Reporting;Research;response;Rewards;Risk;Role;Safety;Self Administration;Severities;sex;Sex Differences;Shapes;Sleep;Sleep disturbances;Sleeplessness;social culture;Social support;Specific qualifier value;Strategic Planning;Stress;stress reactivity;Subgroup;Substance Use Disorder;Symptoms;System;Testing;Therapeutic;therapeutic development;therapeutic opioid;Treatment outcome;treatment planning;treatment response;United States National Institutes of Health;Women's Health;Work

PROJECT_TITLE: Neurofunctional phenotyping to investigate the role of the orexin system at the intersection of opioid use disorder and insomnia

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: HL

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: NEW HAVEN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Diseases of the aorta are increasingly responsible for significant disability and death in the US. There is a pressing need to identify drivers of disease progression for only in this way can new drug targets be identified. This project is significant for we will, for the first time, develop 2 new computer models to better understand disease progression in 3 key mouse models of aortic disease to gain new insight into underlying cellular mechanisms that drive the disease.

PI_NAMEs: HUMPHREY, JAY D. (contact);TELLIDES, GEORGE

PROGRAM_OFFICER_NAME: HSU, LI-YUEH

PROJECT_TERMS: Achievement;Affect;Aneurysm;Anti-Hypertensive Agents;Aorta;Aortic Diseases;Biomechanics;Blood Pressure;Categories;Cell Communication;cell type;Cells;Cessation of life;Chest;clinical care;Communities;Compensation;Computer Models;Data;Data Set;Databases;Devices;Diameter;disability;Disease;Disease Progression;Dissection;diverse data;experience;Extracellular Matrix;Failure;Female;Focus Groups;Gene Expression;Gene Expression Profile;gene product;Genes;Genetic;Genetic Predisposition to Disease;Genetic Transcription;Genotype;Goals;hemodynamics;Heritability;Homeostasis;Hypertension;hypertensive;improved;Individual;Inflammation;innovation;insight;knowledge base;Laboratories;large datasets;Learning;Lesion;Life;Literature;Macrophage;male;Marfan Syndrome;Measurement;Mechanics;mechanotransduction;Medial;Methods;Modeling;Molecular;Monitor;Morbidity - disease rate;mortality;mouse model;Mus;mutant;mutant mouse model;Mutation;new therapeutic target;normotensive;novel;Older Population;Operative Surgical Procedures;Pathologic;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Play;preservation;prevent;Published Comment;recruit;Regulatory Pathway;response;Risk Factors;Role;Rupture;Seminal;sex;sex as a biological variable;Signal Pathway;Signal Transduction;Smooth Muscle Myocytes;Structure;Susceptibility Gene;System;Testing;Thoracic aorta;Time;Tissue Preservation;Tissues;Transcript;Variant;Wild Type Mouse

PROJECT_TITLE: ELUCIDATING MECHANISMS OF THORACIC AORTOPATHY VIA COMPUTATIONAL MODELING

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Lung;Orphan Drug;Rare Diseases

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Project Narrative This project will develop new pulmonary therapeutics against deadly bacterial infections in the lung. They will combine host immune therapy with antibiotics to open new drug strategies against Tier 1 biodefense and global health bacterial threats.

PI_NAMEs: SKERRETT, SHAWN J.;STAYTON, PATRICK S. (contact);WEST, TIMOTHY EOIN

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Adherence;aerosolized;Agonist;Alveolar Macrophages;Amikacin;Animal Model;Anti-Bacterial Agents;Anti-Inflammatory Agents;Antibiotic Resistance;Antibiotics;Antimicrobial Resistance;Bacterial Infections;biodefense;Biodistribution;biothreat;bioweapon;Burkholderia;Burkholderia pseudomallei;Ciprofloxacin;Clinical;clinical development;cohort;Combined Antibiotics;Communicable Diseases;Complex;cost;Death Rate;design;Development;Diffusion;Disease;disease model;Dose;Drug Combinations;Drug Delivery Systems;Drug Kinetics;efficacy evaluation;Enzymes;Exhibits;experience;first-in-human;Francisella;Francisella tularensis;Future;global health;Histologic;Host Defense;human disease;human pathogen;Immune;immune activator;immune modulating agents;Immunologic Stimulation;Immunomodulators;immunoregulation;Immunotherapeutic agent;Immunotherapy;Infection;Inflammasome;Inhalation Device;Innate Immune Response;Leadership;Lung;Lung infections;lung pathogen;Macrophage;Malignant Neoplasms;Mannose;manufacture;Mediator;Melioidosis;Meropenem;Modeling;monomer;Morbidity - disease rate;mouse model;Mus;Nigericin;novel therapeutic intervention;novel therapeutics;Oral;Organ;pathogen;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;Polymers;Positioning Attribute;Prodrugs;prophylactic;Regimen;resiquimod;Resource-limited setting;response;Rodent Diseases;Safety;Schedule;small molecule;Southern Asia;Structure;synergism;Testing;Therapeutic;Time;TLR7 gene;Toxic effect;Tularemia;Universities;Washington;Wild Type Mouse;Work

PROJECT_TITLE: Combination host-directed and antibacterial therapy for pulmonary intracellular infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (81)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health;Stroke

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: Environmental heat and socioeconomic stressors are expected to exacerbate health inequities in persons with Alzheimer’s disease (AD) and AD-related dementia (AD/ADRD). By uncovering the link between environmental heat, socioeconomic disparities, and stroke outcomes, we aim to provide actionable insights that can guide public health policies. Targeting new stroke prevention strategies in heat vulnerable neighborhoods is a more efficient public health approach to improve resilience of vulnerable communities and reduce health inequities in the AD/ADRD population.

PI_NAMEs: SANELLI, PINA CHRISTINE (contact);WANG, JASON J

PROJECT_TERMS: Acute;Age;Alberta province;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Black race;Cessation of life;Cities;clinically relevant;combat;cooling centers;Data;Data Set;Databases;disability;Emergency Situation;Environmental Impact;Environmental Risk Factor;environmental stressor;ethnic diversity;Evaluation;functional improvement;functional outcomes;Goals;Health;health inequalities;Health Policy;Health system;high risk;High temperature of physical object;Hispanic;Hospitalization;Impairment;indexing;insight;Intervention;Ischemic Stroke;Link;Long term disability;Low income;Morbidity - disease rate;mortality;mortality risk;neighborhood association;neighborhood disadvantage;Neighborhoods;New York;novel;Oropharyngeal Dysphagia;Outcome;outcome disparities;Patients;Persons;Population;Population Heterogeneity;Prevention strategy;programs;promote resilience;Public Health;Quality of life;racial diversity;racial minority;racial minority status;Resources;Risk Factors;Role;Sample Size;Severities;sex;socioeconomic disadvantage;socioeconomic disparity;Socioeconomic Factors;socioeconomics;stressor;Stroke;stroke event;stroke intervention;stroke outcome;Stroke prevention;stroke risk;trend;United States National Institutes of Health;vascular risk factor;vulnerable community;Vulnerable Populations

PROJECT_TITLE: Impact of Environmental Stressors on Ischemic Stroke Outcome Inequities in Alzheimers Disease and Related Dementias


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Social Determinants of Health

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative The proposed study aligns closely with several strategies under Goal 2 of the National Plan to Address Alzheimer’s Disease. It addresses issues on the role of healthcare financing and policies on health outcomes, utilization and disparities which are the highest-priority areas for NIH. Knowledge gained from this work can be used to help “optimize care quality and efficiency” and “maintains the dignity, safety, and rights” for persons with ADRD.

PI_NAMEs: KOSAR, CYRUS M;RAHMAN, MD MOMOTAZUR (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Acute;acute care;Address;Adverse event;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;American;Area;care delivery;care outcomes;care systems;Caring;Certificate of Need;Clinical;Clinical assessments;Communities;community based care;Coordination and Collaboration;Cost Sharing;Country;Data;decubitus ulcer;Dementia;Disparity;econometrics;Economic Factors;Economics;end of life care;Enrollment;Equity;ethnic minority;Ethnic Origin;Evaluation;Evolution;Expenditure;experience;falls;federal policy;Funding;Future;Goals;Growth;Health;health care cost/financing;health care disparity;health care service utilization;health disparity;health economics;Health Services;Health Status;Health system;Home;Home Care Services;Home Health Agency;Home Nursing Care;Hospitalization;improved;improved outcome;Income;Individual;Institution;Intervention;Knowledge;Laws;Long-Term Care;Low income;Marketing;Medicaid;Medicare;Medicare claim;Medicare/Medicaid;Methods;Modeling;Neighborhoods;novel;nursing home length of stay;Nursing Homes;older adult;Outcome;payment;Penetration;Persons;Pharmaceutical Preparations;Policies;Population;Prevention;programs;Provider;Quality of Care;Race;racial minority;Research;Resource Allocation;response;Rights;Role;Safety;Services;Side;social vulnerability;Special needs plan;Stream;systems research;Time;Translational Research;United States National Institutes of Health;Variant;Vulnerable Populations;Work

PROJECT_TITLE: Impact of Medicare and Medicaid Financial Policies on Post-acute and Long-term Care for Persons Living with Dementia

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-8 (M4)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Microbiome

ORG_CITY: STATE UNIVERSITY

ORG_DEPT: BIOLOGY

ORG_NAME: ARKANSAS STATE UNIVERSITY

ORG_STATE: AR

PHR: Project Narrative Horizontal gene transfer through mobile genetic elements drives the adaptive evolution of bacterial pathogens and contributes significantly to the spread of pathogenic properties throughout bacterial communities. We recently discovered an integrative and conjugative element (a type of mobile element that is transferred from cell to cell via conjugation) on the genome of the oral pathogen Streptococcus mutans. In this project, we will investigate fundamental aspects of the element’s biology and its influence on S. mutans pathogenesis, including the signals that govern this transfer, interactions with other mobile genetic elements and bacterial defense systems, and elemental mechanisms that may ultimately harm the host bacterial cell.

PI_NAMEs: MCLELLAN, LISA K;SHIELDS, ROBERT COLQUHOUN (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Address;Adult;Affect;Agriculture;Antibiotic Resistance;Arkansas;Award;Bacteria;bacterial community;Bacteriophages;Binding Sites;biological adaptation to stress;Biology;carbohydrate metabolism;Cell Communication;Cell division;cell growth;Cell Physiology;Cells;Child;Clustered Regularly Interspaced Short Palindromic Repeats;combat;Communities;Complex;cost;Defect;Defense Mechanisms;Dental caries;Dental Plaque;Dependence;derepression;Diet;DNA;DNA Damage;driving force;Drug resistance;Elements;Environment;Evolution;Excision;fitness;Gene Expression;Gene Transfer;Genes;genetic element;Genome;global health;Goals;Growth;Horizontal Gene Transfer;Human;Mediating;Metabolic Pathway;Metabolism;microbial;Microbial Biofilms;Mobile Genetic Elements;Modeling;Molecular;Mouth Diseases;Odontogenesis;Oral;oral bacteria;Oral cavity;oral microbiome;oral pathogen;Other Genetics;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Peptide Hydrolases;Phenotype;Physiological;Physiology;Plasmids;pressure;Prevalence;Process;Production;Property;prototype;Regulation;Signal Transduction;Streptococcus mutans;stress tolerance;System;Testing;trait;Universities;Virulence;Virulence Factors;Work

PROJECT_TITLE: Mechanisms of Integrative and Conjugative Elements in Oral Bacteria

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ORG_CITY: ATLANTA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Inherited mutations in mitochondrial genes cause multiple devastating neuromuscular diseases that have no FDA-approved therapies. Here, we are investigating whether correcting a common biochemical consequence of mitochondrial diseases, known as “NADH-reductive stress”, using our novel enzyme tool named LOXCAT, has therapeutic benefits. Our proposal will pave the way for novel therapies for various incurable mitochondrial diseases.

PI_NAMEs: PATGIRI, ANUPAM  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Affect;Albumins;Animal Model;Biochemical;Biochemical Reaction;Blood;Body System;Brain;catalase;Cell Culture Techniques;Cell Proliferation;Cells;Childhood;Complex;Cultured Cells;de-immunization;Dependovirus;design;Disease;Drug Kinetics;Electron Transport;Engineering;Enzymes;Epitopes;Equilibrium;extracellular;FDA approved;Fibroblasts;Functional disorder;Generations;Genes;genetic approach;Glycolysis;Heart;Homeostasis;Homologous Gene;Immune response;Immune system;immunogenic;immunogenicity;Impairment;Inherited;Intravenous;intravenous injection;Knockout Mice;Lactate Dehydrogenase;Leigh Disease;life span;Liver;Membrane Potentials;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Mitochondria;Mitochondrial Diseases;mitochondrial dysfunction;Modeling;mouse model;Mus;muscle strength;Muscle Weakness;Mutation;NADH;NADH dehydrogenase (ubiquinone);Names;Neurologic;Neurologic Symptoms;Neuromuscular Diseases;Neurons;novel;novel therapeutics;Organ;Organelles;Outcome;Oxidases;Oxidation-Reduction;Pathway interactions;Penetration;progressive neurodegeneration;Protein Engineering;Pyruvate;Reaction;Role;Stress;Symptoms;Systemic venous structure;Tail;Testing;Therapeutic;Tissues;tool

PROJECT_TITLE: Targeting NADH-Reductive Stress in Mitochondrial Disease

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Precision Medicine;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_DEPT: OTOLARYNGOLOGY

PHR: NARRATIVES Our goal is to investigate socioeconomic, clinical, imaging, and biological aspects, such as genetic, epigenetic, and transcriptomic/proteomic features that influence the lower survival rate of Oral cavity Squamous Cell Carcinoma (OSCC) patients of African ancestry (AA) compared to those of European ancestry (EA). We will identify the unique characteristics of AA-OSCC and functionally examine the potential therapeutic targets and pathways that are activated in AA-OSCC. Our research will enhance the understanding of the causes of disparities, identify biomarkers that can detect the high-risk group, predict treatment response and survival, and propose novel treatment strategies for AA-OSCC, which could lead to better outcomes and reduced disparities in this neglected population.

PI_NAMEs: GAYKALOVA, DARIA A (contact);MEHRA, RANEE ;REN, LEI

PROGRAM_OFFICER_NAME: OKI, NOFFISAT

PROJECT_TERMS: Address;Admixture;Affect;African ancestry;alternative treatment;American College of Radiology Imaging Network;Artificial Intelligence;artificial intelligence method;biobank;Biological;Biological Factors;Biological Markers;Biology;biomarker identification;cancer care;cancer health disparity;cancer type;Caring;CCNE1 gene;Characteristics;Chromatin;Clinical;Clinical Data;clinical database;Clinical Research;Clinical Trials;cohort;Collaborations;Complex;Comprehensive Cancer Center;Computerized Medical Record;Copy Number Polymorphism;Data;Data Analyses;data integration;Data Set;Databases;demographics;deprivation;design;Detection;Development;Diagnosis;Disease;Disparity;disparity reduction;DNA;DNA Methylation;DNA Repair Enzymes;DNA Repair Gene;DNA Sequence Alteration;Eastern Cooperative Oncology Group;effective therapy;Epigenetic Process;European ancestry;Exhibits;Gene Expression;Genes;Genetic;Genomics;Goals;Grant;Head and Neck Cancer;head and neck cancer patient;Head and Neck Squamous Cell Carcinoma;Head and neck structure;Health Insurance;high risk population;Image;imaging biomarker;improved outcome;indexing;Intervention;Knowledge;lifestyle factors;Link;Malignant Neoplasms;Maryland;Measures;Medical center;Modeling;mouth squamous cell carcinoma;multidisciplinary;Mutation;neglect;Neighborhoods;novel;novel therapeutics;Outcome;outcome disparities;Pathology;Pathway interactions;Patient Self-Report;Patients;personalized diagnostics;personalized medicine;Persons;Physiological;Physiology;Platinum;POLB gene;Population;Positron-Emission Tomography;precision medicine;Prediction of Response to Therapy;predictive marker;predictive modeling;Predictive Value;Prognosis;Prognostic Marker;prognostic value;programs;Proteins;Proteomics;Race;racial disparity;racial diversity;radiological imaging;radiomics;Recurrence;Research;Resistance;response;RNA;Role;Sampling;Single Nucleotide Polymorphism;Site;Smoking;Socioeconomic Factors;socioeconomics;Stains;survival disparity;survival prediction;Survival Rate;synergism;Testing;The Cancer Genome Atlas;Therapeutic Intervention;therapeutic target;Tissue Banks;Tissues;tool;TP53 gene;transcriptomics;Treatment Failure;treatment response;treatment strategy;tumor registry;Universities;X-Ray Computed Tomography;Yale Cancer Center

PROJECT_TITLE: Study of Biological and Radiographic Biomarkers and Association with Ancestry and Survival Disparities in Oral Cavity Squamous Cell Carcinoma Using AI Approaches

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Duchenne/ Becker Muscular Dystrophy;Genetics;Muscular Dystrophy;Pediatric;Rare Diseases

ORG_CITY: LEXINGTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative Muscular dystrophy is a debilitating genetic disorder characterized by progressive loss of muscle function. There is currently no cure and the only effective therapy to delay functional loss is glucocorticoid steroid therapy. The proposed project will investigate a novel mechanism of ribosome specialization as a contributor to the pathogenesis of muscular dystrophy with the aim of developing additional therapies for the disease.

PI_NAMEs: WEN, YUAN  (contact)

PROGRAM_OFFICER_NAME: EISENSTEIN, JANA S

PROJECT_TERMS: Address;Adult;ATP Synthesis Pathway;Biological Assay;career;Cells;Chronic;Contractile Proteins;Cytoplasm;Data;design;Disease;Disease Progression;Dose;Drops;Duchenne muscular dystrophy;effective therapy;Equilibrium;Exercise;exercise training;Failure;functional decline;Functional disorder;functional loss;Generations;Genes;Genetic Diseases;Genetic Transcription;Glucocorticoid Receptor;Glucocorticoids;Growth;Hindlimb;Image;Impairment;improved;In Vitro;in vivo;Knock-out;Knockout Mice;Learning;Maintenance;mdx mouse;Measurement;Measures;Mechanics;Mediating;Mentors;Mentorship;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modeling;Morphology;mouse model;Muscle;Muscle function;Muscle Proteins;muscle strength;Muscular Atrophy;Muscular Dystrophies;new therapeutic target;novel;novel therapeutics;Oxygen Consumption;paralogous gene;Pathogenesis;Pathology;Patients;Performance;Phase;Phenotype;postnatal development;Production;Protein Biosynthesis;protein expression;Proteins;Regulation;Respiratory Diaphragm;restoration;Ribosomal Proteins;Ribosomes;Role;Running;Skeletal Muscle;Specificity;standard of care;Steroid therapy;Steroids;Stress;Striated Muscles;System;Techniques;Testing;Time;Tissues;Training;Transcript;transcriptome sequencing;Translating;Translations;Up-Regulation;Ventilator;Yeasts

PROJECT_TITLE: Contribution of ribosome specialization to the pathophysiology of muscular dystrophy

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Patient Safety;Prevention;Women's Health Research

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE For curatively treated hormone receptor positive breast cancer, taking 5-10 years of a daily oral endocrine therapy such as tamoxifen or an aromatase inhibitor cuts the risk of breast cancer recurrence nearly in half, yet nearly half of women taking endocrine therapy to prevent breast cancer recurrence do not meet minimum thresholds for adherence, often due to symptoms. We propose to test whether oncology teams can improve long-term oral oncologic medication adherence through better symptom monitoring and management.

PI_NAMEs: FLYNN, KATHRYN E (contact);NEUNER, JOAN MARIE

PROGRAM_OFFICER_NAME: RICHMOND, ELLEN S

PROJECT_TERMS: Address;Adherence;Advanced Malignant Neoplasm;anti-cancer treatment;arm;Aromatase Inhibitors;Behavior;Behavior Therapy;Breast Cancer Patient;Breast Cancer Prevention;Breast Cancer Risk Factor;California;Cancer Center;Cancer Control;cancer prevention;cancer recurrence;cancer therapy;care delivery;Caring;chemotherapy;Chronic;Chronic Care;Clinical;Clinical Oncology;Clinical Pharmacists;clinical practice;Clinical Trials;Clinics and Hospitals;common symptom;Communication;comparison intervention;Complex;Cytotoxic Chemotherapy;Data;design;Education;effective intervention;Electronic Health Record;Elements;experience;Feasibility Studies;follow-up;Grant;Guidelines;Health Professional;Health system;high risk;hormone receptor-positive;hormone therapy;hypertension control;improved;insight;interest;Intervention;Joints;Link;Malignant Breast Neoplasm;Mediation;Medical Oncologist;medication compliance;Medication Management;Medicine;member;Menopause;Modeling;Monitor;Muscle;novel;Oncology;Oral;Outcome;outreach;Pain;Patient Compliance;Patient Outcomes Assessments;Patients;Pharmaceutical Preparations;Pharmacists;Pharmacy facility;Physicians;pill;programs;Provider;Randomized;Randomized, Controlled Trials;Reporting;Research;Self Administration;Self Efficacy;Severities;side effect;Social support;success;symptom management;Symptoms;Tamoxifen;team-based care;telephone based;Testing;therapy adherence;Time Study;Translating;treatment arm;treatment as usual;trial design;United States National Institutes of Health;Visit;Waiting Lists;Woman

PROJECT_TITLE: Symptom Monitoring using Patient-Reported Outcomes to Optimize Medication Use (SyMPTOM)

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Effective structural and policy solutions are needed to reduce and eliminate disparities, and these must address the historical, cultural, political and institutional influences that restrict access to resources and quality health for minoritized communities. Community-led health structural interventions (CHESIs) are essential in addressing complex structural drivers of health disparities, however research in this area is often negatively impacted by limited resources, and fraught, superficial relationships with academic partners. To tackle these problems, the SHHare Community Project: The Shared Hub for Health Action Research and Equity in Community-led Interventions at NYU Langone Health (NYULH) will use a community-based participatory research approach to support and ensure the independence of assigned CHESIs by establishing robust, complementary units that ensure CHESIs can successfully implement broader structural change that shift paradigms about community-led solutions to ensure measurable gains in health equity.

PI_NAMEs: ELBEL, BRIAN ;JORDAN, AYANA  (contact);THORPE, LORNA ;TRINH-SHEVRIN, CHAU

PROGRAM_OFFICER_NAME: ACEVEDO, AMANDA MARIE

PROJECT_TERMS: access disparities;access restrictions;Action Research;addiction;Address;Area;clinical care;clinical practice;Collaborations;Communities;community based participatory research;community building;community engaged research;community engagement;Community Health Aides;community intervention;community led intervention;Community of Practice;community organizations;community planning;community research;Community-Led Health Equity Structural Intervention;Competence;Complex;Data;Data Collection;data harmonization;data hub;data management;data quality;disparity elimination;disparity reduction;Doctor of Philosophy;Educational workshop;empowerment;Ensure;Epidemiologist;Epidemiology;Equity;equity, diversity, and inclusion;Evaluation;evidence base;experience;food environment;Funding;Health;health disparity;health equity;Health equity research;health inequalities;Health Services;improved;Individual;Inequity;insight;Institution;International;Intervention;Jordan;Knowledge;Lead;Leadership;learning community;Measurable;Medical Education;Mental Health;Methodology;minority communities;Minority Groups;minority health;Mission;Monitor;multidisciplinary;nutrition;Outcome;Patients;people of color;Personal Satisfaction;Physicians;Policies;Politics;Population Surveillance;Positioning Attribute;Prevention Research;programs;Public Policy;Quasi-experiment;Race;racial discrimination;racial disparity;racism;Reproducibility;Research;Research Activity;Research Design;Research Methodology;Research Support;Resources;Scientist;Shapes;social;social culture;Social Environment;social health determinants;Social Work;structural determinants;structural health determinants;Structure;substance use;success;theories;therapy design;Training;Underserved Population

PROJECT_TITLE: The SHHare Community Project: The Shared Hub for Health Action Research and Equity in Community-led Interventions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-P (52)]


ED_INST_TYPE: SCH OF BUSINESS/PUBLIC ADMIN

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative This research network, the Social Science Genetic Association Consortium, aims to conduct large-scale genomic studies of aging, behavioral, and social phenotypes; broadly disseminate the results and any associated software to the research community, thereby producing resources that will help advance the field; produce and disseminate materials for non-technical audiences about the strengths and limitations of the field; and host monthly online seminars to teach cutting-edge methods to current and new researchers.

PI_NAMEs: BENJAMIN, DANIEL J (contact)

PROGRAM_OFFICER_NAME: BRAUDT, DAVID BRUCE

PROJECT_TERMS: Address;Aging;aging related;Area;Behavioral;behavioral and social science;behavioral study;Biosocial;Brain imaging;Collaborations;Communities;community advisory board;Computer software;Data;Data Set;Development;doctoral student;Educational process of instructing;Epidemiology;Ethics;Exclusion;Family;follow-up;Funding;Gene Expression;Genetic;genetic association;Genome;genome resource;genome wide association study;genome wide methylation;Genomics;Genotype;Goals;health disparity;indexing;Individual;Infrastructure;interdisciplinary collaboration;Manuals;Measures;Medical;Meta-Analysis;Methods;Paper;Phenotype;Policies;population based;Postdoctoral Fellow;pre-doctoral;Publishing;R24;recruit;repository;Research;Research Personnel;research study;Resources;response;Sampling;Science;social;social science research;Social Sciences;Software Tools;statistics;Training;user friendly software;user-friendly;web site;Writing

PROJECT_TITLE: Creating and disseminating resources for the genomics and omics of behavioral and social phenotypes

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-9 (M2)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Precision Medicine

ORG_CITY: CLEMSON

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: PROJECT NARRATIVE The medical and pharmaceutical industries do not yet have the capability to use simulations models to help them predict how patients will respond to drugs or drug combinations. This project focuses on improving such simulation models by combining innovative theory, computation, and experimental approaches in the context of proliferation and death of single cells.

PI_NAMEs: BIRTWISTLE, MARC R. (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Address;Affect;Award;Biochemical;Biology;Cancer cell line;Cell Death;Cell Line;Cell Proliferation;Cells;Cessation of life;Data;Data Set;design;Dose;Drug Combinations;drug development;Drug Industry;drug testing;Encyclopedias;Engineering;FDA approved;Fluorescence;Gene Targeting;Genetic;high dimensionality;improved;Industry;Ingestion;innovation;Mammalian Cell;Medical;Modeling;models and simulation;Molecular;Multiomic Data;Music;next generation;novel;novel strategies;Parents;Patients;Performance;Pharmaceutical Preparations;pharmacodynamic model;Pharmacologic Substance;Pharmacology;Physics;precision medicine;predicting response;Proliferating;Regulation;response;screening;Signal Transduction;Structure;synergism;Testing;theories;Time;undergraduate research;Validation;Variant;Work

PROJECT_TITLE: Diversity Supplement to Support Undergraduate Research for the Parent MIRA Award R35 GM141891 "Mechanistic Pharmacodynamic Modeling for Drug Combinations"

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


NIH_SPENDING_CATS: Clinical Research;Genetics;Infant Mortality;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: DALLAS

ORG_DEPT: PATHOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE  Syphilis is an important cause of stillbirth, neonatal death, and preterm delivery, but there is currently no molecular diagnostic test for congenital syphilis in routine clinical use. We aim to optimize clinical use of a molecular PCR test for detection of T. pallidum DNA in the context of comprehensive assessment of maternal stage, treatment history and neonatal evaluation. We have assembled an outstanding team with complementary expertise and access to a population with high prevalence of maternal and congenital syphilis to accomplish the aims of the study and advance the field of syphilis diagnostics.

PI_NAMEs: ADHIKARI, EMILY H;SORELLE, JEFFREY  (contact)

PROGRAM_OFFICER_NAME: GLOCK, JONATHAN A

PROJECT_TERMS: 2 year old;accurate diagnostics;Address;Adult;Affect;Algorithms;Amniotic Fluid;Antibody titer measurement;Birth;Blood;Blood specimen;bone;Cerebrospinal Fluid;Childhood;Clinic;Clinical;Clinical Research;cohort;Collaborations;Communicable Diseases;Congenital Syphilis;Consent;County;COVID-19;Death Rate;Detection;detection test;Diagnosis;Diagnostic;diagnostic algorithm;Diagnostic Sensitivity;Diagnostic tests;Disease;DNA;DNA-Directed DNA Polymerase;Ensure;Evaluation;Exposure to;Eye;FDA approved;gene conservation;Gene Targeting;Genes;Gills;Globus Pallidus;Health;health care settings;High Prevalence;high risk;Hospitals;Individual;Infection;Inpatients;Laboratories;Life;Liquid substance;Maternal-fetal medicine;Medicine;Meta-Analysis;Molecular;Molecular Diagnostic Testing;molecular diagnostics;Molecular Genetics;Mothers;Mucous Membrane;Musculoskeletal System;Neonatal;Neonatal Mortality;neonate;Newborn Infant;Nucleic Acids;Oral mucous membrane structure;Organism;Oropharyngeal;Pathology;Patients;Performance;Perinatal;Physician Executives;Placenta;Polymerase Chain Reaction;Population;Pregnancy;pregnant;Premature Birth;prenatal;Prevalence;Probability;Publications;Recording of previous events;recruit;research clinical testing;Risk;Risk Factors;risk stratification;safety net;Sampling;SARS-CoV-2 B.1.1.529;SARS-CoV-2 B.1.617.2;SARS-CoV-2 variant;Sensitivity and Specificity;Serology;Serum;Site;Skin;Source;Specialist;Specimen;Staging;stillbirth;Surveys;Swab;Symptoms;Syphilis;Syphilis Serodiagnosis;Techniques;Testing;Tissues;Training;Treponema pallidum;Ulcer;United States;Urine;Use of New Techniques

PROJECT_TITLE: Pre-Analytic Factors affecting Molecular tests for Congenital Syphilis

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 FDS-M (M1)]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_CITY: AMHERST

ORG_DEPT: DENTISTRY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Narrative Candida albicans is a fungus that causes oropharyngeal candidiasis (thrush) in some people but is tolerated without symptoms in the mouth and gut in most healthy individuals. Salivary Histatin 5 (Hst 5) is an abundant zinc-binding antifungal peptide that effectively kills C. albicans without zinc but produces of C. albicans survivor cells with a commensal phenotype when complexed with zinc. We will examine how zinc-Hst 5 complex induced changes to C. albicans (survivor cells) alter their susceptibility to antifungal drugs, interactions with interspecies mucosal binding partners, and dampen inflammatory signaling in the oral mucosa to understand how Zn-Hst 5 modulates fungal commensalism with the goal of tuning the activity of Hst 5 by therapeutic changes in salivary zinc levels.

PI_NAMEs: EDGERTON, MIRA  (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Adherence;Adhesions;anti-fungal agents;Anti-Inflammatory Agents;anti-microbial peptide;Binding;Candida;Candida albicans;Candida glabrata;Caspofungin;Cell Survival;Cell Wall;Cells;Chelating Agents;Clinical Research;Complex;cytokine;Disease;Dose;Environment;Epithelial Cells;Exposure to;Fluconazole resistance;functional improvement;Fungal Peptides;fungicide;fungus;Future;Goals;gut microbiome;histatin 5;Histidine;Homeostasis;Human;Hyphae;IL8 gene;Immunocompromised Host;In Vitro;in vivo;Individual;Inflammation;Inflammatory;Inflammatory Response;Interleukin-10;Invaded;Measures;member;Metalloproteins;Metals;microbial;Microbial Biofilms;mouse model;Mouthwash;Mucous Membrane;mutant;Oral;Oral candidiasis;Oral cavity;oral cavity epithelium;oral microbiome;Oral mucous membrane structure;Organism;oropharyngeal thrush;Persons;Phenotype;Physiological;Population;Predisposition;Property;Resistance;response;Role;Saliva;Salivary;Salivary Proteins;Signal Transduction;Streptococcus gordonii;Survivors;Symbiosis;Symptoms;Testing;Therapeutic;Tissues;Toothpaste;Virulence;Zinc

PROJECT_TITLE: Salivary Zinc modifies Histatin 5 activity towards C. albicans survivor cells and commensalism

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 AC (15)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Eye Disease and Disorders of Vision;Genetics;Human Genome;Liver Disease;Rare Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative This R50 award will support the research specialist Dr. Richard Bennett to lead research teams and perform key experiments to accomplish the aims of the Dr. Licht’s three NCI-funded R01 awards: R01CA266078 (Histone fold Mutations in Cancer Pathogenesis), multi-PI R01CA256193 (Characterization and targeting of the epigenetic state underlying uveal melanoma liver metastasis) and multi-PI R01CA262483 (Defining and targeting epigenetic plasticity-driven drug resistance and immune escape in melanoma). In addition, funding of this award will allow Dr. Bennett to pioneer new directions for each project especially by applying cutting-edge technologies and building collaborations with other NCI-funded investigators. Identifying epigenetic dependencies and pathways implicated in tumor progression and metastasis may lead to improved targeted therapies and ultimately better patient outcomes.

PI_NAMEs: BENNETT, RICHARD L (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: acute lymphoblastic leukemia cell;Amino Acids;anti-cancer research;Award;Biochemical;Biological Assay;Cancer Center;Cancer Intervention;Cancer Patient;Cancer Research Project;career;cell growth;Cells;Chromatin;Collaborations;CRISPR screen;Dependence;Drug resistance;drug withdrawal;Epigenetic Process;epigenomics;experimental study;Florida;Funding;Gene Expression;Gene Expression Profiling;Genetic;Glucocorticoid Receptor;Glucocorticoids;Glutamates;Growth;HDAC8 gene;Health;Heterogeneity;Histone Fold;Histone H2B;histone methyltransferase;Immune;improved;inhibitor;Lead;Lysine;Malignant Neoplasms;Melanoma;Metastatic Neoplasm to the Liver;mutant;Mutation;Neoplasm Metastasis;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Phenotype;programs;Property;receptor expression;Research;Research Personnel;Research Support;Resistance;Specialist;success;targeted treatment;Techniques;Technology;tumor progression;tumorigenesis;Universities;Uveal Melanoma;Work

PROJECT_TITLE: Investigating epigenetic mechanisms of cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-1 (M2)]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Lung;Pediatric;Rare Diseases;Rheumatoid Arthritis

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative The proposed research is relevant to public health because severe lung disease (LD) is an emerging, potentially life-threatening complication of systemic juvenile idiopathic arthritis (SJIA) that frequently progresses to hypoxic respiratory failure. The proposed clinical/observational study represents a needed longitudinal assessment to address key barriers to research in SJIA-LD, including accurate definitions of cases and clinical disease progression, surrogate biomarkers of disease, and lack of LD-specific patient-reported outcomes (PROs). The project is relevant to NIH’s mission to apply knowledge to enhance health, lengthen life, and reduce illness and disability through developing urgently needed tools that are essential to accelerate future clinical research, including interventional studies, in SJIA-LD.

PI_NAMEs: KIMURA, YUKIKO ;SCHULERT, GRANT SANFORD (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Acceleration;Address;Affect;Arthritis;biomarker validation;Characteristics;chemokine;Child;Childhood;Childhood Injury;Chronic lung disease;Clinical;clinical care;Clinical Data;clinical efficacy;Clinical Research;Clinical Trials;cohort;Complication;Consensus;cytokine;Data;disability;Disease;disease phenotype;Disease Progression;disease registry;effective therapy;Enrollment;Fibrosis;follow up assessment;follow-up;Foundations;Future;Goals;Health;Hypoxemic Respiratory Failure;IL18 gene;improved;Incidence;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;Infrastructure;instrument;Interleukin-1;Interleukin-6;Interstitial Lung Diseases;Intervention Studies;Knowledge;Life;Lung Diseases;lung injury;Measurable;Measures;Mission;Multicenter Studies;Natural History;North America;Observational Study;optimal treatments;Outcome;Outcome Measure;Participant;Patient Outcomes Assessments;Patients;Pattern;Physical Function;Physicians;prevent;progression marker;prospective;Prospective cohort;Prospective, cohort study;Proteins;Public Health;Publishing;Pulmonary Alveolar Proteinosis;pulmonary arterial hypertension;Pulmonary function tests;Quality of life;Radiation exposure;Registries;Reporting;Research;research clinical testing;Research Institute;Respiratory Signs and Symptoms;Rheumatology;Serum;Serum Markers;Serum Proteins;Site;specific biomarkers;Surrogate Markers;Surveys;Symptoms;systemic juvenile idiopathic arthritis;Systemic Therapy;Testing;Time;tool;treatment optimization;United States National Institutes of Health;Validation;Vertebral column;Work;X-Ray Computed Tomography

PROJECT_TITLE: Natural history and validation of surrogate biomarkers and patient-reported outcomes for SJIA-LD

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Glioblastoma (GBM) is amongst the most lethal forms of cancer because it can escape the immune system. Results from a series of human clinical trials where we used interleukin 12 immunogene therapy alone or combined with immune checkpoint inhibitors to improve anticancer immunity now prompt us to explore how to improve Interleukin 12 gene therapy by altering the timing of immune checkpoint inhibitors or by blocking a different mechanism of GBM immune escape that relates to a novel long noncoding RNA. By figuring out which of these two approaches is more effective, additional clinical trials for GBM can be designed, informed by this grant proposal.

PI_NAMEs: CHIOCCA, E. ANTONIO (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Adjuvant;Affect;Angiogenesis Inhibitors;anti-cancer;anti-PD-1;anti-PD1 therapy;Applications Grants;bevacizumab;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Characteristics;checkpoint inhibition;chemoradiation;Chronic;Clinical;Clinical Trials;Clinical Trials Design;comparative efficacy;Coupled;cytokine;cytotoxic;cytotoxic CD8 T cells;cytotoxicity;Data;design;Development;Diagnosis;efficacy testing;EGFRvIII Peptide;Excision;exhaustion;Failure;FDA approved;Future;gene therapy;Gliadel;Glioblastoma;Human;Immune;immune activator;immune checkpoint;Immune checkpoint inhibitor;Immune Evasion;Immune system;Immunity;immuno-gene therapy;Immunologic Stimulation;Immunologics;Immunosuppression;Immunotherapy;improved;Infiltration;Inflammatory;Inflammatory Infiltrate;Injections;Interferon Type II;Interleukin-12;Interleukin-12 Gene;Lead;Malignant Neoplasms;Mediating;Modality;Modeling;mouse model;Multi-Institutional Clinical Trial;Myeloid Cells;Myeloid-derived suppressor cells;Neoadjuvant Therapy;neurosurgery;novel;Pathway interactions;PD-1/PD-L1;Peptide Vaccines;Phase;Phase I Clinical Trials;pre-clinical;Pre-Clinical Model;programmed cell death ligand 1;programmed cell death protein 1;Publishing;Recurrence;Series;Signal Pathway;Signal Transduction;small hairpin RNA;standard of care;success;symptomatic improvement;T cell response;T-Lymphocyte;targeted therapy trials;Testing;Treatment Efficacy;treatment response;tumor;Tumor Immunity;tumor microenvironment;Untranslated RNA;Viral;Viral Cancer;Virus Diseases

PROJECT_TITLE: Improving IL12 Immunogene Therapy for Glioblastoma Based on Human Clinical Trial Results

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]