NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Prevention

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: Project Narrative: The 2024 Gordon Research Conference (GRC) on Cardiac Regulatory Mechanisms and its integrated Gordon Research Seminar (GRS), organized by and for early career scientists, are the premier conferences centered on the physiological mechanisms that control normal cardiac function and how they are altered by disease. This meeting will emphasize how basic understanding of regulatory mechanisms can be used to develop new treatments in people. The major goal is to discuss and evaluate the latest findings and emerging new technologies that will improve the treatment of heart disease in the future.

PI_NAMEs: TIAN, RONG  (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Area;Benchmarking;Calcium;Cardiac;cardiac regeneration;Cardiovascular Diseases;Cardiovascular system;career;Cell Therapy;Clinical;Clinical Treatment;clinically relevant;Collaborations;Communication;Coupling;Data;Development;Disease;Disparate;Early Diagnosis;Early Intervention;Environment;environmental enrichment for laboratory animals;Etiology;Evaluation;experience;Fostering;Functional disorder;Future;Generations;Goals;Health;Heart;Heart Diseases;Heart failure;heart function;Heart Research;Immune response;improved;Inflammation;insight;Interdisciplinary Communication;Learning;lectures;meetings;Mentors;Metabolic;Methodology;minority scientist;mitochondrial metabolism;Molecular;Morbidity - disease rate;Morphology;mortality;Myocardial dysfunction;Natural History;Natural regeneration;new technology;next generation;novel;novel therapeutic intervention;novel therapeutics;Organ;Outcome;Pathogenicity;Patient Care;Persons;Physicians;Physiological;posters;Process;programs;Regulation;repaired;Research;Research Personnel;Resolution;Role;Scientist;skills;Social Interaction;Source;Students;success;symposium;System;targeted treatment;Technology;Therapeutic Intervention;Training;Translating;Translations;Underrepresented Minority;United States;Whole Organism;Woman

PROJECT_TITLE: 2024 Cardiac Regulatory Mechanisms Gordon Research Conference and Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-L (J2)]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Cardiovascular;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: GENETICS

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Mitochondria play a key role in human health, and loss of mitochondrial function has been associated with aging- related diseases and overall mortality. We will functionally characterize heteroplasmic nonsense mutations identified in the mitochondrial genome that are associated with increased risk for all-cause mortality.

PI_NAMEs: ARKING, DAN E (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: aging related disease;Alleles;Apoptosis;base;base editing;Base Pairing;Benign;biobank;Biological Assay;Biological Models;Blood Cells;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular Physiology;Cell Line;Cell Physiology;Cell Respiration;Cells;Data;Deaminase;density;design;Development;Disease;DNA Resequencing;Dose;Energy Metabolism;experience;experimental study;frailty;Future;Genes;genetic variant;Genome;genome editing;Health;heart function;heteroplasmy;high throughput screening;HL60;Human;human induced pluripotent stem cells;Hydrogen Peroxide;Individual;Inherited;insight;K-562;Link;Lymphocyte;Messenger RNA;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;mitochondrial genome;Monitor;mortality;mortality risk;mutant;Mutation;Nature;neutrophil;Nonsense Mutation;Nuclear;Participant;Play;protein complex;Proteins;Reactive Oxygen Species;response;Risk;Role;Sampling;Series;Signal Transduction;Site;Somatic Mutation;Superoxides;Technology;Testing;Untranslated RNA;Variant;whole genome

PROJECT_TITLE: Functional Characterization of Mitochondrial Genome Nonsense Mutations

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

PHR: Project Narrative Epilepsy is a chronic condition affecting 70 million people worldwide. Development of novel therapeutic strategies to better treat and potentially prevent and cure this devastating condition requires scientific advances to increase our understanding of the multifaceted mechanisms responsible for epilepsy. This conference will bring together experts from around the world, as well as scientists in training, in an intensive, immersive environment to present and discuss novel findings, facilitate dissemination of knowledge and create new, cross-disciplinary collaborations that should significantly advance research directed towards better treatment of epilepsy.

PI_NAMEs: SANTHAKUMAR, VIJAYALAKSHMI  (contact);SCHARFMAN, HELEN E

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Acceleration;Address;Adopted;Affect;Basic Science;career;Career Choice;career development;Cerebrum;Child Care;Chronic;Clinical Sciences;Collaborations;collaborative environment;Communication;Communities;comorbidity;Complex;Dedications;design;Development;Disabled Persons;Disease;Disease Progression;Ensure;Environment;Epilepsy;Epileptogenesis;ethnic minority;Family;Fostering;Funding;Generations;Genetic;Goals;graduate student;Hour;Human;Immune signaling;Immunologist;Individual;insight;interest;Knowledge;Learning;Medical;meetings;Mentors;Mentorship;Metabolism;Minority Groups;Molecular;Molecular Profiling;National Institute of Neurological Disorders and Stroke;Neuroimmune;Neurons;neuropathology;neurovascular;novel;novel therapeutic intervention;novel therapeutics;Patients;peer networks;Persons;Physiology;Postdoctoral Fellow;posters;pre-clinical;prevent;Process;Productivity;programs;Quality of life;racial minority;Research;Research Personnel;research study;Resort;Science;Scientific Advances and Accomplishments;Scientist;Seizures;Senior Scientist;Series;Signal Transduction;Site;Students;symposium;Syndrome;System;Therapeutic;Time;Training;transcriptomics;Translating;translational approach;translational study;Underrepresented Minority;Underrepresented Populations;virtual reality environment;Woman;Work

PROJECT_TITLE: 2024 Mechanisms of Epilepsy Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-K (43)]


ADMINISTERING_IC: ES

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Diabetes;Endocrine Disruptors;Obesity

ORG_CITY: IOWA CITY

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Polychlorinated biphenyls (PCBs) persist in the built and natural environment leading to human exposure and increased risk of metabolic diseases such as diabetes and obesity. The development of metabolic diseases often begins in adipose tissue, the lipid-rich depot also responsible for PCB accumulation. This project will uncover the systems-level mechanisms by which PCBs contribute to adipose dysfunction and inflammation through the disruption of cellular crosstalk between adipocytes and macrophages.

PI_NAMEs: BEHAN-BUSH, RILEY  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: adipocyte differentiation;Adipocytes;adipokines;adiponectin;Adipose tissue;Affect;Anti-Inflammatory Agents;Antibodies;Attention;Biomedical Engineering;career;Cell Survival;cell type;Cells;Chemotaxis;Coculture Techniques;Communication;cytokine;Data;Development;Diabetes Mellitus;Disease;Endocrine;Endocrine Disruptors;Endothelial Cells;Environment;environmental chemistry;experience;exposed human population;Exposure to;Fellowship;Functional disorder;Future;Gene Expression;Goals;heart disease risk;Hyperlipidemia;IL8 gene;Image;Immune;immune activation;Infiltration;Inflammation;Inflammatory;insulin sensitivity;insulin sensitizing drugs;Link;lipid biosynthesis;Lipids;Macrophage;Malignant Neoplasms;Medicine;Mesenchymal Stem Cells;Metabolic;Metabolic Diseases;Metabolic syndrome;migration;monocyte;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Outcome;paracrine;Pathologic;Phenotype;Play;Polychlorinated Biphenyls;Proliferating;recruit;Regulation;Research;Risk;Role;Signal Transduction;Site;Stroke;Surface;System;systemic inflammatory response;Testing;TNF gene;Toxic Environmental Substances;Toxicology;Work

PROJECT_TITLE: The Effects of Polychlorinated Biphenyls on Adipocyte-Macrophage Crosstalk

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F06-L (20)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Wound Healing and Care

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Narrative There is a critical need to develop non-antibiotic modalities to tackle multidrug-resistant bacteria. This proposal aims to explore a novel bacteria-specific pro-photosensitizer, which can sufficiently kill multidrug-resistant (MDR) bacteria when combined with light. The success of the study will provide a much-needed non-antibiotic approach to the battle against infectious diseases.

PI_NAMEs: WU, MEI X (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acinetobacter baumannii;Address;Affect;Aminolevulinic Acid;antibiotic design;Antibiotic Resistance;Antibiotic susceptibility;Antibiotics;Bacteria;bacterial resistance;bactericide;Binding;Cells;Cellular Phone;Cessation of life;Chemosensitization;chronic wound;Clinical;Combined Modality Therapy;Communicable Diseases;cost;Detection;disability;DNA;drug resistant microorganism;economic cost;Effectiveness;Ensure;Escherichia coli;Family;Family suidae;Focal Infection;Futile Treatments;Genus staphylococcus;Glutamates;Health Care Costs;Healthcare Systems;Human;In Vitro;in vivo;Incubated;Infection;innovation;Klebsiella;Klebsiella pneumoniae;Lasers;Length of Stay;Life;Light;light emission;Lipids;Malignant Neoplasms;Mammalian Cell;Mammals;Mediating;methicillin resistant Staphylococcus aureus;Microbial Biofilms;microbicide;microorganism;Modality;Multi-Drug Resistance;multi-drug resistant pathogen;Multiple Bacterial Drug Resistance;Mus;Nosocomial Infections;novel;open wound;Organism;Outcome;pathogen;Pathway interactions;Persons;Photosensitizing Agents;Phototherapy;Phytochemical;Plants;Pneumonia;porphyrin biosynthesis;Porphyrins;Predisposition;Production;Productivity;Proteins;Pseudomonas aeruginosa;PUVA Photochemotherapy;Reactive Oxygen Species;Refractory;Research Personnel;Resistance;Resistance development;Risk;Safety;Skin;Societies;Specificity;Staphylococcus aureus;success;Testing;Tetrapyrroles;theranostics;Time;Transfer RNA;urgent and serious threat;Visit

PROJECT_TITLE: A novel bacteria-specific pro-photosensitizer

STUDY_SECTION: DMPA

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology A Study Section [DMPA]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: WORCESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE In 2018, Massachusetts’ Medicaid program, MassHealth, launched a new Accountable Care Organization (ACO) delivery and payment system to better deliver integrated person-centered care that meets members’ social, behavioral, and physical health needs.9 Prior studies have shown that healthcare integration may improve care quality, reduce healthcare costs, and increase patient satisfaction; however, there is limited published research on clinical, behavioral health, and social service integration in primary care practices for Medicaid members with behavioral health conditions.10-12 In this one-year, mixed-methods study, we will analyze the impact of clinical and social services integration on healthcare utilization and experiences of MassHealth members with behavioral health conditions.

PI_NAMEs: SABATINO, MEAGAN J (contact)

PROGRAM_OFFICER_NAME: CHANLONGBUTRA, AMORNRAT

PROJECT_TITLE: Care Integration, Supportive Housing, and Outcomes for Medicaid Accountable Care Organization Enrollees with Behavioral Health Conditions

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BIRMINGHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: NARRATIVE Overall The UAB CFAR catalyzes new and supports ongoing HIV research across all domains – in partnership with communities most affected by HIV. Through our structure, relationships with community, public health, and academic partners, and institutional support, we are positioned to support high-impact discoveries towards the achievement of HIV research priorities and curbing the HIV epidemic in Alabama, the Deep South, and globally.

PI_NAMEs: HEFFRON, RENEE A. (contact)

PROGRAM_OFFICER_NAME: SCHOONMAKER, ANNALISE ROSA

PROJECT_TERMS: Achievement;Acquired Immunodeficiency Syndrome;Affect;Aging;AIDS prevention;Alabama;Area;Award;base;Basic Science;Behavioral Sciences;biobehavior;Biology;Career Choice;Caring;Clinical;Clinical Research;Clinical Sciences;Communities;community organizations;community partners;community science;comorbidity;Cytotoxic T-Lymphocytes;Data Science;Dedications;Deep South;Development;Discipline;Disease Progression;driving force;Epidemic;equity, diversity, and inclusion;Ethnic Origin;experience;Extramural Activities;Foundations;Funding;Gender;global health;Grant;Growth;HIV;Immune response;implementation science;Infection;Infrastructure;innovation;Institution;Investments;Leadership;Lived experience;Methodology;Mission;multidisciplinary;neutralizing antibody;next generation;novel;novel therapeutics;Persons;Policies;Positioning Attribute;Process;Public Health;Quality of life;Race;recruit;Research;Research Personnel;Research Priority;Role;Science;Scientist;Services;Strategic Planning;Structure;substance use;Technology;Time;tool;Training;Underrepresented Minority;United States National Institutes of Health;Universities;Virus Replication;Woman;working group

PROJECT_TITLE: UAB Center for AIDS Research (CFAR)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 KSW-A (J1)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Substance Misuse

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Advisory Committees;Alabama;Area;base;billboard;Clinical;Collaborations;Communication;Communities;community organizations;Community Outreach;community partners;community science;Development;Educational workshop;Effectiveness;Electronic Mail;Electronics;Ensure;Environment;equity, diversity, and inclusion;Event;Feedback;Financial Support;Fostering;Funding;Future;global health;Growth;HIV;implementation science;Individual;innovation;Interdisciplinary Study;interest;Leadership;meetings;member;Mission;Monitor;multidisciplinary;next generation;organizational structure;Outcome Measure;Periodicals;Play;Process;recruit;Research;Research Personnel;Research Priority;Research Project Grants;Role;Services;social media;Strategic Planning;Structure;substance use;symposium;synergism;System;Technology;timeline;tool;Training;Training and Education;training opportunity;United States National Institutes of Health;Universities;web site;working group

PROJECT_TITLE: Administrative Core (Core A)


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Substance Misuse

PI_NAMEs: GOEPFERT, PAUL A. (contact)

PROJECT_TERMS: 2019-nCoV;Acquired Immunodeficiency Syndrome;Affect;Alabama;antiretroviral therapy;Area;Award;Basic Science;bench to bedside;career;career development;Clinical;Clinical Research;Clinical Sciences;cohort;Collaborations;Communities;community building;community engaged research;community engagement;community partners;COVID-19 pandemic;Development;Educational workshop;Emerging infection;Environment;Epidemic;Extramural Activities;Faculty;Financial Support;Fostering;Funding;Funding Opportunities;graduate student;Grant;Height;HIV;HIV diagnosis;implementation science;innovation;interest;investigator training;Investments;Laboratories;Learning;Mentors;Mentorship;Methods;Mission;next generation;novel;Pathogenesis;Persons;Positioning Attribute;Prevention;Process;Program Development;programs;public health emergency;Recording of previous events;recruit;Research;Research Personnel;Research Priority;Research Support;response;Science;Scientist;skills;Strategic Planning;Structure;success;synergism;Time;Training;treatment optimization;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Universities;virology;Woman;Work;working group;Writing

PROJECT_TITLE: Developmental Core (Core B)


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Biotechnology;Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Substance Misuse

PI_NAMEs: KUTSCH, OLAF  (contact)

PROJECT_TERMS: Acceleration;Achievement;Acquired Immunodeficiency Syndrome;Alabama;Area;ATAC-seq;Award;base;Bioinformatics;bioinformatics pipeline;Biomedical Research;Cells;Chromium;Collaborations;college;Communities;computer infrastructure;Computer software;Containment;Core Facility;cost;Data;Data Analyses;data sharing;Data Storage and Retrieval;Department chair;design;Development;DNA Library;Doctor of Philosophy;empowerment;Flow Cytometry;Funding;genomic platform;Genomics;Goals;Grant;high end computer;Historically Black Colleges and Universities;HIV;humanized mouse;Image;Incubators;Infrastructure;innovation;insight;Institution;Instruction;instrument;instrumentation;Laboratories;Licensing;member;Mentors;Metadata;Methodology;Methods;Microbiology;Mission;mouse model;next generation;novel;operation;outreach;Paper;Phase;phosphoproteomics;Preparation;Principal Investigator;Process;Production;Productivity;programs;Proteomics;Publishing;Recycling;Research;Research Personnel;Resources;Sampling;Scientist;Series;Services;single cell analysis;single-cell RNA sequencing;software development;Speed;STEM program;Structure;Students;synergism;System;Technology;technology platform;Time;Tissue Donors;Tissue Procurements;tool;Training;training opportunity;transcriptome sequencing;transcriptomics;undergraduate student;United States National Institutes of Health;Universities;user-friendly;vector;Work

PROJECT_TITLE: Advanced Technology Core (Core H)


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Rural Health;Social Determinants of Health;Substance Misuse

PI_NAMEs: ELOPRE, LATESHA ELLEN (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;AIDS prevention;Alabama;Applications Grants;Award;Back;biobank;Biological;Biological Specimen Banks;Biometry;career;Caring;Client;Clinic;Clinical;clinical care;Clinical Data;clinical epidemiology;Clinical Research;clinically relevant;cohort;Cohort Studies;Collaborations;Collection;Color;Communities;community collaboration;community organizations;Community Services;community setting;complex data;Computer software;computerized;Consent;data access;Data Analyses;data management;Data Scientist;Data Set;Data Sources;Databases;Deep South;Development;Diagnosis;Disparity;Disparity population;effective intervention;electronic data;Elements;Ensure;Environment;Epidemic;Epidemiologist;Epidemiology;experience;Extramural Activities;foot;Funding;gender minority group;Generations;Geographic Locations;Goals;Grant;Health;health care availability;health equity promotion;health inequalities;HIV;HIV Infections;HIV Seronegativity;Human immunodeficiency virus test;Imprisonment;improved;Informatics;Information Dissemination;Infrastructure;innovation;Institutional Racism;Intervention;Intervention Studies;Link;Manuscripts;Mission;Observational Study;Outcome;patient engagement;patient oriented;Patient Outcomes Assessments;Patients;Peer Review;Persons;Physicians;Play;point of care;Policies;Population;population health;Positioning Attribute;Poverty;pre-exposure prophylaxis;Prevention;prevention service;Process;Productivity;prospective;Public Health Informatics;recruit;Registries;Research;Research Design;Research Infrastructure;Research Personnel;Research Support;Resources;Role;Rural;Rural Community;Sampling;Scholarship;Science;Scientific Advances and Accomplishments;Scientific Inquiry;Scientist;service coordination;service delivery;Services;sexual minority group;Site;social health determinants;Specimen;Statutes and Laws;synergism;System;Time;Translational Research;Treatment outcome;treatment services;Universities;Vial device;vulnerable community

PROJECT_TITLE: Clinical Core (Core C)


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Services;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Substance Misuse

PI_NAMEs: RANA, AADIA  (contact)

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;AIDS prevention;Alabama;Applications Grants;Award;base;Behavioral;Behavioral Sciences;Bibliography;big-data science;certificate program;Clinic;Clinical;Collaborations;Communities;community based research;community collaboration;community engagement;Community Health;community organizations;community partners;community science;Consultations;Continuity of Patient Care;Data;data dictionary;Data Set;Deep South;design;Economics;Educational workshop;Electronics;Elements;Epidemic;Equity;Ethics;Event;Extramural Activities;Faculty;Feedback;Foundations;Funding Opportunities;Geography;Goals;Grant;Growth;health care settings;health equity;Health Services Research;HIV;Hybrids;implementation science;innovation;Intervention;Laboratories;large datasets;Leadership;Libraries;Measurement;Medicaid;member;Mentors;Methodology;Mission;multidisciplinary;next generation;Outcome;Peer Review;Population;Population Surveillance;Positioning Attribute;programs;psychosocial;Public Health;Publications;Rana;Research;Research Design;Research Methodology;Research Personnel;research study;Research Training;Resources;response;Robin bird;Sampling;Science;Services;skills;social;success;surveillance data;symposium;synergism;Training;Training and Education;training opportunity;transmission process;United States National Institutes of Health;Work;working group

PROJECT_TITLE: Implementation and Community Sciences Core  (Core D)


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Rural Health;Social Determinants of Health;Substance Misuse

PI_NAMEs: EATON, ELLEN FLORENCE (contact)

PROJECT_TERMS: Acceleration;Accident and Emergency department;Acquired Immunodeficiency Syndrome;addiction;Address;Adopted;Affect;AIDS prevention;Alabama;anti-racism;antiretroviral therapy;Beds;career;Chemicals;Clinic;Clinical;clinical care;cohort;Collaborations;Communities;community advisory board;community engagement;Community Health;community organizations;community partners;community partnership;comorbidity;County;Dedications;Deep South;Developing Countries;Development;Diagnosis;Disparity;Drug user;early-career faculty;Educational workshop;Epidemic;Epidemiologic Factors;ethnic minority population;experience;Extramural Activities;Faculty;Faith;Feedback;Focus Groups;Fostering;Funding;Growth;Harm Reduction;Health;Health behavior;health equity;Health equity research;Health system;Healthcare;Hepatitis C;HIV;HIV disparities;HIV risk;Hospitals;Individual;innovation;Institutional Racism;Learning;Legal;Lived experience;marginalized population;member;Mentors;Needle Sharing;Needs Assessment;Opioid;opioid epidemic;Outcome;Overdose;Persons;Pharmaceutical Preparations;Population;posters;programs;Prostitution;Public Health;racial minority population;Research;Research Activity;Research Methodology;Research Personnel;Research Project Grants;Risk;Risk Behaviors;rural area;Science;Scientist;sex;Sexually Transmitted Diseases;social health determinants;Social Justice;Social Sciences;social stigma;Structure;substance use;Substance Use Disorder;symposium;Training;training opportunity;Translating;transmission process;underserved area;Underserved Population;vulnerable community;Work;working group

PROJECT_TITLE: Substance Use SWG


PI_NAMEs: VINIKOOR, MICHAEL JEFFREY (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Africa;AIDS prevention;Alabama;base;Characteristics;Cognitive Therapy;Coin;Collaborations;comorbidity;Complex;Consultations;Country;Deep South;Development;Diagnostic;Director's Working Group;Disparity;Educational workshop;Epidemic;Equity;Event;experience;Extramural Activities;Faculty;Feedback;forging;Funding;Funding Mechanisms;Funding Opportunities;Geographic Locations;Geography;global health;Grant;Health;Health Priorities;HIV;Hybrids;Income;innovation;Institution;interest;Intervention;Lead;Learning;Legal;Link;low and middle-income countries;member;Methodology;Monitor;multidisciplinary;novel;Outcome;Participant;Population;pre-exposure prophylaxis;Prevention program;Process;programs;Publications;Research;research faculty;Research Personnel;Resource-limited setting;Series;social stigma;substance use;success;Systems Development;Technology;Training;Translating;translational potential;treatment program;United States National Institutes of Health;Viral;working group

PROJECT_TITLE: Global Health Reciprocal Innovations SWG


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Hypertension;Kidney Disease;Nutrition;Prevention

ORG_CITY: BLOOMINGTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE High dietary salt intake is a well-established risk factor for high blood pressure, cardiovascular disease (CVD) and chronic kidney disease (CKD), yet ~90% of Americans consume excess dietary salt based on the recommendations set by the Dietary Guidelines for Americans and the American Heart Association. The established link between dietary salt with CVD and CKD, particularly in older adults, highlights a critical biomedical research need for strategies to counteract the adverse cardiorenal consequences of high dietary salt; and we have identified beta-hydroxybutyrate, a liver-derived ketone body, as a potential target to counteract the adverse cardiorenal effects high dietary salt. Using a randomized placebo-controlled crossover design study, we will test the hypothesis that concurrently giving a ketone monoester supplement (exogenous source of beta- hydroxybutyrate) with high dietary salt (10 days) will attenuate the effects of short-term high dietary salt on cardiorenal health (blood pressure, peripheral vascular function, kidney injury biomarkers, and kidney blood flow) in older adults.

PI_NAMEs: ROBINSON, AUSTIN TYLER (contact)

PROGRAM_OFFICER_NAME: GAO, HONGWEI

PROJECT_TERMS: Acute;Adult;adult obesity;Adverse effects;Adverse event;adverse outcome;Affect;Aging;American;American Heart Association;Anti-Inflammatory Agents;arterial stiffness;Attenuated;beta-Hydroxybutyrate;Biological Assay;Biological Markers;Biomedical Research;Blood flow;Blood Flow Velocity;Blood Pressure;blood pressure control;blood pressure reduction;blood pressure variability;Blood Vessels;brachial artery;cardioprotection;Cardiorenal syndrome;Cardiovascular Diseases;Cardiovascular Physiology;Cause of Death;Chronic Kidney Failure;Consumption;Creatinine clearance measurement;Crossover Design;Data;Diet;dietary;dietary guidelines;dietary salt;disorder risk;Doppler Ultrasound;Excess Dietary Salt;Exercise;Fasting;feeding;Female;Femur;Food;Funding;Future;Glomerular Filtration Rate;Goals;Health;Hepatic;high salt diet;Human;human data;Hypertension;improved;Individual;Injury to Kidney;innovation;Intervention;ketogenic diet;Ketone Bodies;Ketones;Kidney;Knowledge;Laboratories;Leg;Link;Liver;Lower Extremity;male;Masks;Measures;Mediating;modifiable risk;Morbidity - disease rate;mortality;Movement;novel strategies;older adult;Oral;Organ;Outcome;Peripheral;Physiologic pulse;pilot trial;Placebo Control;Plasma;Postmenopause;prevent;Process;Production;Productivity;protective effect;Public Health;Publications;Publishing;Randomized;Rattus;Recommendation;Regulation;renal artery;Research;Research Design;Research Personnel;Rest;Restaurants;Risk;Risk Factors;Rodent;salt intake;Secure;Sodium Chloride;Source;Stimulus;Supplementation;Techniques;Testing;tool;Translating;United States;Upper Extremity;urinary;Vascular Diseases;Vasodilator Agents;young adult

PROJECT_TITLE: Dietary Ketone Supplementation as a Novel Strategy to Attenuate the Adverse Vascular and Renal Consequences of High Dietary Salt in Older Adults

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Behavioral and Social Science;Mental Health;Neurosciences

PHR: Project Narrative The field of synaptic biology is relevant to nearly every question in neurobiology, from development to aging and from sensory processing to sleep and cognition. Synapses are also the primary site of neuronal degeneration and dysfunction in diseases and disorders ranging from Alzheimer’s to Amyotrophic Lateral Sclerosis (ASL), epilepsy, intellectual disability, autism, and schizophrenia. The 2024 Synaptic Transmission Gordon Conference will bring together international leaders and rising stars, creating a diverse, inclusive, dynamic forum to communicate, contemplate and advance our understanding of the most pressing and fascinating current topics in synapse biology.

PI_NAMEs: DAVIS, GRAEME W (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Advertising;Aging;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;autism spectrum disorder;Behavior;Behavior Control;Biology;Caliber;career;career development;Cognition;Collaborations;Communication;Complex;Computer Models;Creativeness;design;Development;Disease;Environment;Epilepsy;equity, diversity, and inclusion;Faculty;fascinate;Functional disorder;Gender Identity;Generations;Goals;graduate student;Health;Hour;Individual;Industry;Intellectual functioning disability;interest;International;Italy;Learning;Life;life span;meetings;Mental disorders;Mentors;millisecond;Modality;Molecular;Movement;nanometer resolution;nanoscale;nanoscale research;Nationalities;Nerve Degeneration;Nervous System Disorder;neural;Neurobiology;Neuronal Dysfunction;Neurons;Neurosciences;novel therapeutics;Participant;Patients;Perception;Postdoctoral Fellow;posters;programs;Renaissance;Research;Research Personnel;response;Schizophrenia;Science;Scientist;Sensory;Site;Sleep;Specific qualifier value;symposium;Synapses;Synaptic plasticity;Synaptic Transmission;System;Time;Underrepresented Populations;Woman;Work

PROJECT_TITLE: 2024 Synaptic Transmission Gordon Research Conference and Seminar


ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Overall PROJECT NARRATIVE The CFAR’s mission is to advance cutting-edge HIV/AIDS research on the Penn/CHOP/Wistar campus that will contribute innovative solutions to the AIDS crisis. The CFAR achieves this mission by providing scientific and administrative leadership to generate new research directions and collaborations; providing shared resource cores that support research through critical enabling technologies; leveraging institutional resources; training and mentoring the next generation of researchers and leaders and attracting scientists from other fields; and establishing partnerships and generating synergy with other groups on campus, in Philadelphia, nationally and internationally.

PI_NAMEs: COLLMAN, RONALD G (contact)

PROGRAM_OFFICER_NAME: WONG, ELAINE WAI-KEN

PROJECT_TERMS: Abbreviations;Acceleration;Acquired Immunodeficiency Syndrome;Address;Advisory Committees;antibody test;antiretroviral therapy;Appointment;Area;base;Behavioral;Behavioral Research;Binding;biobehavior;Biomedical Research;Biometry;Botswana;Case Management;Cells;chimeric antigen receptor T cells;Clinical;clinical epidemiology;Clinical Trials Unit;Collaborations;collaboratory;Communication Research;Communities;community advisory board;community engagement;community organizations;community research;comorbidity;COVID-19;Data Science;Development;Disparate;diversity and inclusion;Educational Activities;Ensure;Epidemic;equity, diversity, and inclusion;Evaluation;Faculty;first-in-human;Focus Groups;Fostering;Funding;Genome;Goals;Health;health disparity;health equity;Health equity research;Historically Black Colleges and Universities;HIV;HIV vaccine;HIV/AIDS;Immune;immune function;Immunology;implementation science;implementation strategy;Individual;Infrastructure;Injecting drug user;innovation;innovative technologies;insight;Institution;Interdisciplinary Study;International;international partnership;Intervention;Knowledge;Lead;Leadership;Lymphoid;Medical;medical schools;Medicine;member;Mental Health;Mentors;Messenger RNA;Mission;Modeling;Molecular;Monitor;neutralizing antibody;next generation;NIH Office of AIDS Research;nonhuman primate;novel;organizational structure;outreach;Pediatric Hospitals;Pennsylvania;Persons;Philadelphia;Pilot Projects;Policies;Policy Research;Positioning Attribute;pre-exposure prophylaxis;Prevention;Primates;Process;programs;Public Health;recruit;Reporting;Research;Research Personnel;Research Priority;Research Project Grants;Research Support;Resource Sharing;Resources;School Nursing;Schools;Science;Scientist;Sexual and Gender Minorities;simian human immunodeficiency virus;SIV;social;Social Policies;Strategic Planning;success;synergism;Technology;The Wistar Institute;Time;trafficking;Training;transgender;United States National Institutes of Health;Universities;Vaccines;Virus;working group;young men who have sex with men

PROJECT_TITLE: Penn Center for AIDS Research


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Substance Misuse

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Administrator;Advisory Committees;Advocate;Affect;Area;arm;Biometry;Botswana;Businesses;Caring;Cells;Clinical;Collaborations;Communication;Communities;community advisory board;community engagement;community research;comorbidity;Data Science;Development;diversity and inclusion;Education;Ensure;Evaluation;Faculty;Feedback;Funding;Generations;Goals;Grant;Health;HIV;HIV/AIDS;Immune;Immunology;implementation science;Individual;innovation;Institution;interdisciplinary collaboration;Interdisciplinary Study;International;Lead;Leadership;member;Mentors;Modeling;Molecular;Monitor;multidisciplinary;next generation;novel;organizational structure;outreach;outreach program;Pediatric Hospitals;Pennsylvania;Philadelphia;Policies;Positioning Attribute;Prevention;Process;programs;Public Health;public health priorities;recruit;Research;Research Personnel;Research Priority;Resource Allocation;Resource Sharing;Resources;Role;Science;Scientific Advances and Accomplishments;Secure;Services;social determinants;sound;Strategic Planning;synergism;Technology;The Wistar Institute;Tissues;Training;Underrepresented Minority;United States National Institutes of Health;Universities;Vaccines;Virus;Woman;Work;working group

PROJECT_TITLE: Administrative Core A


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: O'DOHERTY, UNA T (contact)

PROJECT_TERMS: Abbreviations;Acquired Immunodeficiency Syndrome;Address;Advisory Committees;antiretroviral therapy;Area;Award;Basic Science;Behavioral Sciences;Biomedical Research;career;Clinical;Clinical Sciences;Collaborations;collaborative environment;Communities;community advisory board;community organizations;community partners;cost;Data;Development;Educational Status;Educational workshop;electronic data;Epidemic;equity, diversity, and inclusion;experience;Faculty;Feedback;Fostering;Funding;Goals;Grant;health economics;Helper-Inducer T-Lymphocyte;Historically Black Colleges and Universities;HIV;HIV/AIDS;implementation science;innovation;Institution;instructor;interest;Investments;Joints;Journals;K-Series Research Career Programs;low and middle-income countries;Medicine;meetings;men who have sex with men;Mental Health;Mentors;Mentorship;Mission;Monitor;neutralizing antibody;next generation;novel;outreach;Pediatric Hospitals;Pennsylvania;Persons;Philadelphia;Postdoctoral Fellow;pre-doctoral;pre-exposure prophylaxis;Principal Investigator;Process;programs;Public Health;Publishing;recruit;Request for Applications;Research;Research Personnel;Research Priority;Resources;response;Schools;Scientist;Series;Sexually Transmitted Diseases;skills;Social Policies;Strategic Planning;Study Section;synergism;System;Talents;Targeted Research;Time;tool;Training Programs;Translational Research;Underrepresented Populations;United States National Institutes of Health;Universities;user-friendly;Work;working group

PROJECT_TITLE: Developmental Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biotechnology;Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Immunization;Infectious Diseases;Prevention;Substance Misuse;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: BAR, KATHARINE JUNE (contact)

PROJECT_TERMS: Abbreviations;Acceleration;Acquired Immunodeficiency Syndrome;Advisory Committees;AIDS Vaccines;Animals;Antibodies;Antigens;antiretroviral therapy;Area;Autologous;Bar Codes;Basic Science;Bioinformatics;Biological Assay;Biological Specimen Banks;career;Cells;clinical development;Clinical Trials;Collaborations;collaboratory;Communities;Complex;Consultations;Custom;deep sequencing;density;design;Dideoxy Chain Termination DNA Sequencing;digital;DNA;early phase clinical trial;Education;Epitope Mapping;equity, diversity, and inclusion;Experimental Designs;first-in-human;Foundations;gene therapy;Genome;Goals;Historically Black Colleges and Universities;HIV;HIV vaccine;HIV-1;Human;humanized mouse;Immunology;innovation;integration site;Intervention;Leadership;Medicine;member;Mentors;Mission;Molecular;Molecular Cloning;Molecular Virology;Monoclonal Antibodies;neutralizing antibody;nonhuman primate;novel;novel strategies;outreach;Pathway interactions;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Philadelphia;Poly A;Population;pre-clinical;preclinical development;Preclinical Testing;programs;Protocols documentation;Reagent;repository;Research;research clinical testing;Research Personnel;Research Priority;response;Retroviral Vector;RNA;Science;screening;service programs;Services;simian human immunodeficiency virus;single cell analysis;SIV;Technology;Training;Translational Research;Translations;transmission process;United States National Institutes of Health;vaccine discovery;Vaccines;Variant;Viral;Viral Load result;Viral Proteins;Viral reservoir;virology;Virus;Work;working group;zinc finger nuclease

PROJECT_TITLE: Virus & Reservoirs Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Immunotherapy;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: RILEY, JAMES L. (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Advanced Development;Antibodies;Applications Grants;Area;B-Lymphocytes;bench to bedside;Biological Assay;Biology;Budgets;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Therapy;Cells;Certification;Client;Clinical;Clinical Research;Clinical Trials;Clinical Trials Design;Collaborations;collaboratory;Collection;Communities;Complex;computational pipelines;Consultations;Cryopreservation;Custom;cytokine;Data Analyses;data pipeline;design;Development;digital;Disease remission;early phase clinical trial;Education and Outreach;Ensure;enzyme linked immunospot assay;Enzyme-Linked Immunosorbent Assay;Equipment;Equipment and supply inventories;Evolution;experimental study;first-in-human;Funding;Grant;HIV;HIV Infections;HIV-1;HIV/AIDS;Human;Immune;Immune response;Immune system;Immunologic Techniques;Immunologics;Immunologist;Immunology;Immunology procedure;Immunophenotyping;Immunotherapy;Innate Immune Response;innovation;Institutional Review Boards;Interdisciplinary Study;Laboratories;Lead;Leadership;Learning;Leukapheresis;Management Information Systems;meetings;Mentors;Metadata;Methodology;Mission;Molecular;monocyte;Multiomic Data;multiple omics;Natural Killer Cells;new technology;next generation sequencing;novel;novel vaccines;Pathogenesis;Patients;Peripheral Blood Mononuclear Cell;Persons;Phase I Clinical Trials;Philadelphia;Physicians;Population;prevent;Prevention approach;Procedures;Protocols documentation;Publications;Quality Control;recruit;Reporting;Research;Research Personnel;Research Support;Resources;Sampling;Scientist;service delivery;Services;skills;student training;success;symposium;T-Cell Receptor;T-Lymphocyte;Technical Expertise;Technology;Training;Translational Research;United States National Institutes of Health;Vaccines;Virus;Visualization;Work

PROJECT_TITLE: Molecular & Translational Immunotechnology Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Pediatric;Pediatric - AIDS;Pediatric Cancer;Prevention;Rare Diseases;Substance Misuse

PI_NAMEs: LO RE, VINCENT  (contact)

PROJECT_TERMS: Abbreviations;Acquired Immunodeficiency Syndrome;Address;Adolescent;Adult;Advisory Committees;Aging;AIDS clinical trial group;AIDS prevention;antiretroviral therapy;Area;Award;Behavioral;Behavioral Sciences;Biological;Biological Markers;Biological Specimen Banks;Biomedical Research;Blood;Blood Component Removal;Cannulations;Caring;Cells;cervical biopsy;Characteristics;Child;Childhood;Clinical;clinical epidemiology;clinical material;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Network;Clinical Trials Unit;Collaborations;Collection;Communication;Communities;community organizations;comorbidity;Computerized Medical Record;Consultations;Data;data acquisition;Data Set;Databases;design;Development;diversity and equity;dynamical evolution;Education;education research;Educational Activities;Eligibility Determination;Epidemiology;equity, diversity, and inclusion;Faculty;Feedback;Fostering;Foundations;Funding;gastrointestinal;genital secretion;Grant;Health;health care disparity;Health Policy;Health Services Research;Health system;Helper-Inducer T-Lymphocyte;HIV;HIV Infections;HIV prevention trials network;HIV Vaccine Trials Network;HIV/AIDS;Immunologics;Immunology;implementation science;improved;Individual;Industry;Injecting drug user;innovation;Institution;Interdisciplinary Study;International Maternal Pediatric Adolescent AIDS Clinical Trials;Interruption;Knowledge;Laboratories;Laboratory Infection;Leadership;Link;Lymph;lymphatic duct;Lymphoid Tissue;Maintenance;Manuals;Master of Science;medical schools;Medicine;member;men who have sex with men;Mental Health;Mentors;Mentorship;Mission;Modality;neutralizing antibody;operation;Outcome;outreach;Participant;Pathogenesis;Pathway interactions;patient oriented;Patient Recruitments;Patients;Pediatric Hospitals;Pennsylvania;Perinatal;Peripheral Blood Mononuclear Cell;Persons;Philadelphia;Plasma;Policies;Population;pre-exposure prophylaxis;Prevention;prevention clinical trial;Procedures;Process;Productivity;protocol development;psychosocial;Public Health;Publications;recruit;Rectum;Reporting;repository;Research;Research Design;Research Personnel;Research Priority;Research Project Grants;research study;Research Support;Resources;response;Risk;Risk Factors;Science;screening;Serum;service utilization;Services;Sexually Transmitted Diseases;Shipping;Specimen;STI prevention;Strategic Planning;success;Thoracic Duct;Tissue Microarray;Tissues;Training;transmission process;trend analysis;United States National Institutes of Health;Universities;University Hospitals;Virus;volunteer;Wood material;working group;young men who have sex with men

PROJECT_TITLE: Clinical Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Services;Infectious Diseases;Prevention;Rural Health;Substance Misuse

PI_NAMEs: METZGER, DAVID S (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;AIDS prevention;Award;Awareness;Behavioral Sciences;Botswana;career;Caring;Clinical;Collaborations;Communication;Communication Research;Communities;community advisory board;community based research;community engagement;Community Health Education;Community Networks;community organizations;community partners;community partnership;community research;community setting;Consultations;Country;County;COVID-19 pandemic;Databases;design;Detection;Development;Discipline;diversity and inclusion;efficacious intervention;Ensure;Epidemic;Equipment;Ethnic Population;Evaluation;Funding;Funding Opportunities;Gatekeeping;Generations;Goals;high risk;HIV;HIV diagnosis;HIV Infections;HIV/AIDS;HIV/STD;Human immunodeficiency virus test;implementation barriers;implementation science;Improve Access;improved;Individual;Infrastructure;innovation;International;Intervention;Lead;Leadership;Link;member;Mentors;Mentorship;Mission;Monitor;Names;Nature;Participant;Perception;Persons;Philadelphia;Policy Research;Population;Prevention;prevention service;Process;Productivity;programs;Provider;racial population;recruit;Reporting;Research;research facility;Research Infrastructure;Research Personnel;research study;Resources;response;Risk Reduction;Scholars Program;Science;Scientist;service delivery;Services;Social Sciences;Structure;Support Groups;synergism;Testing;tool;Training;Trust;Underrepresented Populations;Update;Viral;Virus;Work;working group

PROJECT_TITLE: Community Research & Engagement Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Data Science;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Services;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: STEPHENS SHIELDS, ALISA JANE (contact)

PROJECT_TERMS: Abbreviations;Acquired Immunodeficiency Syndrome;Adolescent;Adult;Advisory Committees;Aging;AIDS prevention;antiretroviral therapy;Applied Research;Area;Award;Bachelor's Degree;Basic Science;Biological Specimen Banks;Biomedical Research;Biometry;Botswana;Case Management;Clinical;Clinical Research;Clinical Trials;Clinical Trials Data Monitoring Committees;Clinical Trials Unit;cohort;Collaborations;collaboratory;Communities;Consult;Consultations;COVID-19;Data;Data Analyses;Data Collection;data management;data quality;Data Science Core;Databases;Degree program;design;Development;diversity and equity;Education;Electronic Health Record;Elements;eligible participant;Emergency Situation;empowerment;Engineering;Epidemic;Epidemiology;equity, diversity, and inclusion;Evaluation;Experimental Designs;Extramural Activities;Faculty;Fostering;Funding;Graduate Degree;Grant;Health;Health protection;Health system;HIV;HIV/AIDS;Human Resources;Image;implementation science;Individual;Informatics;Injecting drug user;innovation;instrument;International;Investigation;K-Series Research Career Programs;Knowledge;Leadership;Link;Medical;medical schools;Medicine;Mentors;Mentorship;Methodology;Mission;novel;pandemic disease;Participant;Pathway interactions;Pediatric Hospitals;Persons;Philadelphia;Pilot Projects;Population Sciences;Postdoctoral Fellow;pre-doctoral;pre-exposure prophylaxis;Preventive;programs;Public Health;Quasi-experiment;Reporting;Reproducibility;Research;Research Design;Research Personnel;Research Priority;Research Project Grants;Resources;response;School Nursing;Schools;Sequential Multiple Assignment Randomized Trial;Sexual and Gender Minorities;Site;Social Policies;Specimen;Statistical Data Interpretation;statistics;Students;System;Therapeutic;Time;tool;Training;wearable device;working group

PROJECT_TITLE: Biostatistics & Data Science Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: MOMPLAISIR, FLORENCE M (contact)

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;AIDS prevention;behavioral economics;Biometry;Botswana;care outcomes;career;Caring;Cities;Collaborations;Communication;Communities;community academic partnership;community building;community engaged approach;community engaged research;community engagement;community research;Consultations;Continuity of Patient Care;County;Data Science;design;Diagnosis;Discipline;Doctor of Philosophy;Education;Ensure;Epidemic;epidemic preparedness;Equity;Evidence based intervention;Eye;falls;Funding;Generations;Goals;Government;Health;health equity;HIV;HIV Infections;HIV/AIDS;implementation context;implementation efforts;implementation science;improved;improved outcome;Inequity;Infection;Infrastructure;International;Knowledge;Leadership;Maintenance;Maps;Measures;Mentorship;Methods;Outcome;outreach;pandemic disease;Persons;Philadelphia;Policies;prevent;Prevention;Prevention strategy;programs;Public Health;Publications;Recording of previous events;Research;Research Personnel;Resources;Science;Scientific Advances and Accomplishments;Scientist;Services;success;synergism;Target Populations;Training;treatment response;treatment services;treatment strategy;United States National Institutes of Health;Universities;working group

PROJECT_TITLE: Implementation Science Core


PI_NAMEs: GROSS, ROBERT  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adolescent;Affect;Africa South of the Sahara;Area;Awareness;Biometry;Botswana;candidate identification;Child;Clinical;clinically relevant;cognitive rehabilitation;Collaborations;community partners;Consultations;Country;data management;design;Educational process of instructing;Ensure;Environment;Epidemic;Epidemiology;Ethics;Faculty;Feedback;Foundations;Funding;Future;global health;Grant;Health;HIV;HIV Infections;HIV/AIDS;Human Subject Research;improved;in utero;Infrastructure;innovation;Institution;Institutional Review Boards;interest;International;Joints;Laboratories;laboratory experience;Language;Leadership;lens;Link;low and middle-income countries;Malignant neoplasm of cervix uteri;medical schools;Mentors;Mission;Monitor;new technology;next generation;Nicotine Dependence;operation;outreach;patient oriented;Personal Satisfaction;Persons;Philadelphia;Physical Rehabilitation;Population;Positioning Attribute;pre-exposure prophylaxis;prevent;Process;programs;Protocols documentation;Recording of previous events;Reporting;Research;research faculty;Research Infrastructure;Research Personnel;Research Priority;Research Project Grants;Resources;response;Rest;Scientist;Secure;Services;severe mental illness;Shipping;Sister;Site;skill acquisition;skills;smoking cessation;Southern Africa;Specimen Handling;Speech;Strategic Planning;synergism;Training;Training Activity;Translations;Tuberculosis;United States National Institutes of Health;Universities;uptake;Vision;Work

PROJECT_TITLE: International Core


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: AUSTIN

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative The proposed research will investigate the role of the understudied gene, CACNA2D4, in the context of inherited retinal disease. CACNA2D4 encodes for a2d-4, which is a subunit of the voltage-gated Cav family of ion channels. Our research is expected to illuminate new mechanisms controlling the processing of visual information in normal and diseased states of the retina, and pave the way for the development of novel therapeutic approaches to treat inherited retinal disorders.

PI_NAMEs: LEE, AMY  (contact)

PROGRAM_OFFICER_NAME: SHARMA, KARLIE ROXANNE

PROJECT_TERMS: Affect;Architecture;Cells;Chemosensitization;Chimeric Proteins;Clinical;Color;Complete Blindness;Complex;Cone dystrophy;cone-rod dystrophy;Contrast Sensitivity;density;design;Development;diagnostic strategy;Discrimination;Disease;Electrophysiology (science);Electroporation;Epilepsy;extracellular;Family;Feedback;gene therapy;Genes;Genome;Genotype;Glutamates;Goals;horizontal cell;in vivo;in vivo evaluation;in vivo optical imaging;Inherited;insight;Ion Channel;Ion Channel Protein;Knockout Mice;Knowledge;Left;Life;Light;Link;Mediating;Methodology;Mission;Molecular;Mus;mutant;Mutation;Nature;neuroprotection;neurotransmitter release;novel;novel therapeutic intervention;Outcome;Pain;patch clamp;Pharmaceutical Preparations;Phenotype;Photophobia;Photoreceptors;Physiological;preservation;presynaptic;Presynaptic Terminals;programs;Proteins;Protons;Publishing;Rare Diseases;Recombinants;Research;response;Retina;Retinal Cone;Retinal Degeneration;Retinal Diseases;Retinal Dystrophy;Retinal Photoreceptors;retinal rods;Retinitis Pigmentosa;ribbon synapse;Rod;Role;Series;Signal Transduction;Site;stem;Structure;Symptoms;Synaptic Cleft;synaptic function;System;Techniques;Testing;therapeutic target;trafficking;Transfection;Variant;Vertebrate Photoreceptors;Vesicle;Vision;Visual Acuity;Visual impairment;visual information;visual processing;voltage;Von Willebrand Factor A Domain

PROJECT_TITLE: Illuminating the function of CACNA2D4 in inherited retinal dystrophies

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 RD-1 (01)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Pediatric

ORG_CITY: Los Angeles

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE The biological determinants of Alzheimer’s disease and related dementias (ADRD) are established decades before clinical symptoms of cognitive decline, memory loss and functional decline are observed. As age is the most reliable predictor of ADRD, the proposed study will test whether biological age, as opposed to chronological age, predicts higher levels of preclinical AD biomarkers, as measured with a highly reliable plasma beta-amyloid (Aβ) marker, and whether Aβ accumulation contributes to cognitive decline in midlife in a well-established longitudinal twin sample, the Louisville Twin Study. The nature of this twin design will inform causal pathways between early life development, biological age, Aβ, and cognitive functioning at midlife, shedding light on genetic and environmental mechanisms that promote risk and resilience of preclinical AD.

PI_NAMEs: BEAM, CHRISTOPHER RYAN (contact);DAVIS, DEBORAH WINDERS

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: abeta accumulation;Address;Adult;Age;Alzheimer's disease related dementia;Amyloid beta-Protein;Archives;Arithmetic;Biological;biological age;Biological Aging;Biological Markers;Child;Child Development;Childhood;Chronology;Clinical;Cognition;cognitive ability;cognitive development;cognitive function;cognitive task;cognitive testing;Data Collection;design;Development;Environmental Risk Factor;Etiology;functional decline;Funding;Future;Genetic;Goals;Grant;Growth;Impaired cognition;Individual;innovation;Intelligence;Life;life span;Light;Link;Measures;Memory Loss;Methods;middle age;Modeling;Nature;Neurobehavioral Manifestations;Pathway interactions;Plasma;pre-clinical;Protocols documentation;resilience;response;Risk;Sampling;Specific qualifier value;Standardization;Symptoms;Testing;theories;trend;Twin Multiple Birth;Twin Studies;United States National Institutes of Health;Update;Vocabulary

PROJECT_TITLE: Contribution of child development, biological aging, and beta-amyloid to cognitive function of the Louisville twins at midlife


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Lipoproteins are essential particles that transport fats to different cells in the brain. In individuals with Alzheimer’s disease (AD), lipoproteins are not taken up by cells properly and instead bind to other factors outside the cell such as amyloid, leading to amyloid plaque formation, and damage to brain tissue and function. In this proposal, we aim to enhance the activity of the enzyme lipoprotein lipase (LPL), which can help specialized cells called microglia remove excess lipoproteins, prevent amyloid accumulation, and protect against the development of AD.

PI_NAMEs: BRUCE, KIMBERLEY D (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: age related;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer's neuropathogenesis;Amyloid;Amyloid beta-Protein;Apolipoprotein E;apolipoprotein E-4;Binding;Biology;Brain;brain tissue;Cells;Clinical;Data;Development;Disease Progression;Disease susceptibility;effective therapy;enzyme activity;Enzymes;epidemiology study;Fatty acid glycerol esters;Functional disorder;gain of function;Gatekeeping;Human;Hydrolysis;immune function;improved;in vivo;Individual;knock-down;Laboratories;Left;lipid metabolism;lipid transport;Lipids;lipoprotein lipase;lipoprotein lipase activators;Lipoproteins;metabolic imaging;Metabolism;Microglia;Mus;Neurodegenerative Disorders;novel;Onset of illness;particle;Phagocytes;Phagocytosis;pharmacologic;Play;Positioning Attribute;Prevalence;prevent;Protein Isoforms;Role;Scaffolding Protein;Senile Plaques;Testing;therapeutic target;uptake;Variant

PROJECT_TITLE: Targeting Microglial Lipoprotein Lipase in Alzheimer's disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PHR: Project Narrative While memory deficits are common among older adults, some individuals remain resilient to cognitive decline. Understanding the functional and neurochemical factors that influence cognitive resilience is key to advancing the field of cognitive aging towards better treatments and care for older adults facing cognitive decline. In this proposal we will use a multimodal neuroimaging approach to study the effects of dopamine, tau, and age on memory ability in the face of Alzheimer’s-related pathology.

PI_NAMEs: MORIN, THOMAS  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Affect;Age;age effect;age related;age related decline;Age-associated memory impairment;age-related disease;Aging;aging brain;Alzheimer's Disease;Amyloid;Anxiety;Attenuated;Behavioral;Biological;biomedical imaging;Brain;Caring;Cognition;Cognitive;Cognitive aging;cognitive function;cohort;Collaborations;Data;Dopamine;Dopamine Receptor;dopamine system;Education;Episodic memory;executive function;experimental study;Functional disorder;Functional Magnetic Resonance Imaging;Future;Hippocampus;hyperphosphorylated tau;Impaired cognition;improved;Individual;Individual Adjustment;Individual Differences;Joints;Least-Squares Analysis;Longitudinal Studies;Measures;medial temporal lobe;Mediating;Memory;memory encoding;Memory impairment;Methodology;multimodal neuroimaging;multimodality;neural;neurochemistry;neuroimaging;neuropathology;Neuropsychology;neuroregulation;normal aging;older adult;Participant;Pathology;Performance;Pharmaceutical Preparations;Pharmacologic Substance;Placebos;Plasma;Positron-Emission Tomography;pre-clinical;preservation;Process;Proteins;Raclopride;receptor density;Research Personnel;resilience;reward processing;Rewards;Ritalin;Sampling;Scanning;secondary analysis;Signal Transduction;System;tau aggregation;tau Proteins;Testing;training opportunity;trait;Universities;Work

PROJECT_TITLE: Conjoint Effects of Dopamine and Tau on Cognition in Aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01A-V (20)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Gene Therapy;Genetics;Neurodegenerative

ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE This research aims to create an entirely new hybrid viral vector delivery vehicle for CRISPR gene therapy which will be able to efficiently insert multiple genes into specified locations within the genomes of target cells. In the long term, this platform technology will enable genetic treatments for complex ailments of aging and aging-related conditions, especially Alzheimer’s disease.

PI_NAMEs: COLLINS, LOGAN THRASHER (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Abbreviations;Address;Adenoviruses;Aging;aging related;Alzheimer's Disease;Amyloidosis;Avidity;BCAR1 gene;Blindness;Capsid;Cell surface;Cells;cellular targeting;cellular transduction;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR therapeutics;Data;delivery vehicle;Dependovirus;design;Diameter;DNA;DNA Packaging;Dose;Electron Microscopy;experience;Fiber;Gene Delivery;Gene Proteins;gene therapy;Gene Transduction Agent;Genes;Genetic;Genome;Genomics;Guide RNA;Hybrids;in vivo;Leber's amaurosis;Lentivirus;Link;lipid nanoparticle;Liver diseases;Location;Mendelian disorder;microscopic imaging;new technology;novel;particle;Positioning Attribute;pre-clinical;Prealbumin;prevent;Proteins;Protocols documentation;prototype;Renaissance;repaired;Research;Risk;Side;Single-Stranded DNA;Site;Specific qualifier value;Structure;Surface;System;Technology;technology platform;Therapeutic Effect;therapeutic genome editing;transduction efficiency;Transgenes;uptake;vector;Viral Vector

PROJECT_TITLE: A Novel Hybrid Viral Vector for Therapeutic CRISPR Insertion of Multiple Transgenes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: NEW YORK

ORG_DEPT: BIOLOGY

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative The dysregulation of Hox gene expression patterning leads to body part transformations and is associated with tumor progression, thus, precise understanding of Hox gene regulation will enhance our understanding and potential engineering of normal development and disease. However, the current model for Hox gene regulation has only been investigated in piece-meal using tedious low throughput techniques allowing for only a few modifications at a time due to limitations in DNA synthesis and delivery technologies. The proposed research seeks to utilize a novel synthetic DNA engineering approach to ectopically insert an entire HoxA cluster (~130kb) to study its internal regulatory elements and understand how Hox genes decode transient patterning signals into epigenetic information.

PI_NAMEs: RAGIPANI, BHAVANA  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Acids;Animals;Anterior;Behavior;Bilateral;Binding;Binding Sites;Body part;Boundary Elements;CCCTC-binding factor;cell fate specification;Chromatin;chromatin modification;Code;Collaborations;Complex;CRISPR/Cas technology;Defect;Development;Disease;DNA biosynthesis;DNA delivery;DNA Sequence;Drosophila genus;Elements;Embryo;Engineering;Enhancers;epigenetic memory;Epigenetic Process;extracellular;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene repression;Gene Structure;Genes;Genetic Transcription;Homeobox Genes;Mammalian Cell;Measures;Modeling;Modification;Motor Neurons;Mouse Embryonic Stem Cells;Mus;Mutate;Mutation;Neuronal Differentiation;novel;Output;Pattern;Pluripotent Stem Cells;Polycomb;promoter;Proteins;Rattus;recruit;Regulation;Regulatory Element;Repression;Research;Retinoic Acid Response Element;Retinoids;Signal Transduction;Site;synthetic construct;System;Techniques;Technology;Testing;Time;transcription factor;transcriptome sequencing;Tretinoin;tumor progression;Variant;Yeasts;Zinc Fingers

PROJECT_TITLE: Understanding Hox epigenetic memory formation during motor neuron differentiation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Nutrition;Prevention;Substance Misuse

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE The proposed research studies aim to identify the pharmacokinetic interactions between a ketone supplement and alcohol in blood and brain of healthy, socially drinking adults. The proposed studies will generate fundamental knowledge on the potentially beneficial effects of a nutritional ketone supplement in decreasing alcohol sensitivity and increasing alcohol tolerance in human participants. Ketone supplements may lead to the identification of new approaches for alcohol clearance during intoxication, and/or the development of novel therapeutics for alcohol use disorder.

PI_NAMEs: NANGA, RAVI PRAKASH REDDY ;WIERS, CORINDE E (contact)

PROGRAM_OFFICER_NAME: GRAKALIC, IVANA

PROJECT_TERMS: 18 year old;Acceleration;Acetoacetates;Acetone;Adult;Affect;Alcohol consumption;alcohol craving;Alcohol dehydrogenase;Alcohol dependence;alcohol effect;alcohol intervention;alcohol measurement;alcohol misuse;alcohol response;alcohol sensitivity;alcohol use disorder;Alcohol withdrawal syndrome;Alcoholic Intoxication;Alcohols;Blood;Blood alcohol level measurement;Brain;breath alcohol measurement;cancer risk;Chronic;cofactor;cognitive control;cognitive function;cognitive performance;Consumption;Crossover Design;Data;Detection;Development;dietary;dietary restriction;Dose;drinking;Drug Kinetics;Drug Metabolic Detoxication;Energy Metabolism;Environment;Enzymes;Ethanol Metabolism;Functional Imaging;Functional Magnetic Resonance Imaging;Glucose;glucose metabolism;healthy volunteer;Heavy Drinking;Hour;Human;Human Volunteers;Hydroxybutyrates;improved;Individual Differences;Ingestion;Intake;Intoxication;ketogenic diet;Ketones;Ketosis;Knowledge;Laboratories;Laboratory Study;Legal;Liver Cirrhosis;magnetic resonance spectroscopic imaging;Measures;men;Metabolism;Methodology;Molecular;Neurocognitive Deficit;Nicotinamide adenine dinucleotide;novel strategies;novel therapeutics;Nutritional;Outcome Study;Participant;Patients;Performance;Phase;Placebos;prevent;Prevention;Production;Rattus;recruit;Reducing diet;Reporting;research study;response;Risk;Rodent;Rodent Model;Scanning;social;Taste Perception;Testing;United States;vehicular accident;Visit;Withdrawal Symptom;Woman

PROJECT_TITLE: Modulation of alcohol sensitivity and alcohol tolerance by exogenous ketones in humans

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE In chronically infected individuals, the latent HIV reservoir is not silent and may induce inflammation, but the pathways leading to this aberrant inflammation are poorly understood, particularly in pediatric populations who acquired HIV perinatally. The project will elucidate these pathways in perinatally-infected adolescents and mechanistically define drivers using organoid models as a step towards novel therapeutics.

PI_NAMEs: BLISH, CATHERINE A (contact)

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: 3-Dimensional;Adolescent;Adult;Age;Algorithms;Antibodies;antiretroviral therapy;Automobile Driving;Cardiovascular system;CD4 Positive T Lymphocytes;Cell Communication;cell type;Cells;Child;Childhood;Chronic;Clinical;cohort;Communication;Complement;Coupled;CRISPR/Cas technology;Disease;Disease Progression;Environment;Face;Gene Expression;Genes;Genetic Transcription;Goals;HIV;HIV Infections;HIV-infected adolescents;Human;Human immunodeficiency virus test;Immune;immune activation;Immune system;Immune System Diseases;in vivo;Individual;Infection;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;inhibitor;insight;Kenya;latent HIV reservoir;Life;Lymphoid;Lymphoid Tissue;Maps;Metabolic;Methods;Modeling;Neurocognitive;novel;novel therapeutics;Organoids;Pathology;Pathway interactions;pediatric human immunodeficiency virus infection;Perinatal;perinatal HIV;Peripheral Blood Mononuclear Cell;Population;Proteins;Provirus Integration;Residual state;Resolution;Resources;Risk;RNA;Role;Sampling;secondary lymphoid organ;sex;Signal Transduction;single-cell RNA sequencing;Site;Small Interfering RNA;small molecule;small molecule inhibitor;Source;Structure;System;Techniques;Testing;therapeutic evaluation;three-dimensional modeling;Tissues;Transfection;Validation;Viral;Viral Genes;Viral Load result;Virus;Virus Replication;Vulnerable Populations

PROJECT_TITLE: High resolution inflammatory networks induced by HIV reservoirs in adolescents

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 JBS-A (J1)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Patient Safety;Prevention;Rare Diseases;Rural Health;Social Determinants of Health

PHR: Project Narrative: Improving the timeliness and quality of care of rural underserved lung cancer (LC) and head and neck cancer (HNC) patients is important because delays treatment are associated with disparities in disease recurrence, lower survival and poor patient outcomes compared to patients who are not underserved. We will evaluate an intervention that targets key factors associated with treatment delays and poor quality of care. Our objective is to disseminate an evidence-based intervention into clinical practice to effectively improve the timeliness and quality of care for rural underserved patients and reduce disparities in LC and HNC morbidity and mortality.

PI_NAMEs: BORRAYO, EVELINN  (contact)

PROGRAM_OFFICER_NAME: WEAVER, SALLIE JAYNE

PROJECT_TERMS: Adoption;Affect;Anxiety;Appointment;Behavioral Model;Breast Cancer Patient;Cancer Advocacy;cancer diagnosis;cancer health disparity;Cancer Patient;cancer recurrence;cancer therapy;care coordination;care outcomes;care providers;care systems;Caring;Case Management;Charities;clinical practice;Clinical Trials;Clinical Trials Design;clinically significant;Clinics and Hospitals;Collaborations;Colorado;Communication;comorbidity;coping;cost effective;cost effectiveness;Diagnosis;Disease;Disparity;disparity reduction;Dissemination and Implementation;Distress;education resources;effectiveness evaluation;Effectiveness of Interventions;Enabling Factors;Ethnic Origin;Evidence based intervention;experience;Face;financial toxicity;frontier counties;Goals;Head and Neck Cancer;head and neck cancer patient;health care delivery;Health Services Accessibility;Health system;Healthcare Systems;Hospitals;implementation evaluation;improved;Income;Individual;Insurance;Insurance Coverage;Intervention;intervention delivery;intervention effect;Literature;Low income;low socioeconomic status;Lung;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Medical Oncology;Mental Depression;Modeling;Montana;Morbidity - disease rate;mortality;Operative Surgical Procedures;Outcome;Outcome Study;patient navigation;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;perceived stress;pragmatic implementation;Predisposing Factor;primary outcome;Quality of Care;Quality of life;Race;Radiation Oncology;Randomized;Randomized Controlled Clinical Trials;Randomized, Controlled Trials;recruit;Recurrent disease;Reporting;Rural;rural area;rural counties;rural patients;rural underserved;scale up;secondary outcome;sex;side effect;Sister;Stress;Subgroup;Surveys;The University of Colorado Cancer Center;Time;Tobacco use;Travel;treatment as usual;Treatment outcome;treatment site;trial design;tumor;Underinsured;Underserved Population;Uninsured;Universities;Utah;Vulnerable Populations;Work;Wyoming

PROJECT_TITLE: Improving the Timeliness and Quality of Care for Rural Lung and Head-and-Neck Cancer Patients


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: HERSHEY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: Project Narrative Opioid use disorder (OUD) ruins the lives of those with the disorder and those around them, while also placing higher healthcare and economic burden on the United States. Here we will use drug self-administration and light sheet microscopy to identify the impact of high vs. low fentanyl seeking on brain in male and female rats and we will test the ‘need-state’ hypothesis by determining whether treatment with a glucagon-like peptide-1 receptor agonist (GLP-1RA) not only rescues vulnerable rats from fentanyl seeking but also reengages the GLP-1 ‘satiety’ pathway and disengages substrates involved in reward and seeking.

PI_NAMEs: EVANS, BRIANNA  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: addiction;Address;Agonist;antagonist;Attenuated;Behavior;Behavioral;Brain;Buprenorphine;COVID-19 pandemic;Cues;Data;Disease;Distress;Drug usage;DSM-V;Economic Burden;Exhibits;Female;Fentanyl;fentanyl seeking;fentanyl use disorder;Gene Expression;Genes;GLP-I receptor;glucagon-like peptide 1;healthcare burden;Heroin;Homeostasis;Hypothalamic structure;Individual Differences;Infusion procedures;innovation;Intake;Lateral;Light;Liquid substance;liraglutide;male;Mediating;medication-assisted treatment;Methadone;Microscopy;motivated behavior;Naltrexone;neural circuit;novel;opioid overdose;opioid use;opioid use disorder;Overdose;overdose death;Oxycodone;Pathway interactions;Pattern;Persons;Pharmaceutical Preparations;Pharmacology;Prediction of Response to Therapy;Preparation;protective effect;Quantitative Reverse Transcriptase PCR;Rattus;Relapse;Reporting;Rewards;Rodent Model;Saline;Satiation;Self Administration;Site;social stigma;Sprague-Dawley Rats;Structure;Substance Abuse Detection;Substance of Abuse;synthetic opioid;Testing;United States;Vulnerable Populations;Water;Withdrawal

PROJECT_TITLE: Fentanyl Addiction: Individual Differences, Neural Circuitry, and Treatment with a GLP-1 Receptor Agonist


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

PHR: Veterans with dysvascular lower limb amputation (LLA) have a high fall risk, which persists despite completion of conventional rehabilitation. The presence of fall risk could be a primary reason for the high disability and low quality of life outcomes in this Veteran population. A potential novel intervention for this population is to train performance of tasks that require both physical and cognitive attention (i.e, dual-tasking). Therefore, the purpose of this study is to explore relationships between dual-task performance and self-reported falls for Veterans with dysvascular LLA. Further, dual-tasking occurs during everyday life and this project will examine the associations between dual-task performance and participation in activities of daily living (basic and instrumental). The results will form the foundation for development and future study of a novel dual-task training program for Veterans with dysvascular LLA.

PI_NAMEs: SWINK, LAURA ANITA (contact)

PROJECT_TERMS: Activities of Daily Living;Adult;Age;Amputation;Attention;Award;Awareness;Behavior Therapy;Behavioral Mechanisms;Blood Vessels;Categories;Clinical;clinical training;Cognition;Cognitive;cognitive load;cognitive performance;cognitive task;cohort;Communities;comorbidity;Data;Dedications;design;Development;disability;Educational Intervention;Etiology;experience;Fall prevention;fall risk;falls;Foundations;Future;Gait;Gait speed;Goals;Health;high risk;improved;indexing;Individual;Infrastructure;instrumental activity of daily living;Intervention;Intervention Trial;Interview;Life;limb amputation;Lower Extremity;Measures;Medical;Mentors;meter;Methods;military veteran;Motor;Needs Assessment;novel;older adult;Oral;Outcome;Parents;Participant;Pathology;Patient Self-Report;Performance;Persons;Phase;physical conditioning;Population;Population Intervention;primary outcome;Process;programs;Psyche structure;Quality of life;Recurrence;Rehabilitation therapy;Reporting;Research;Research Design;Research Personnel;Resources;response;Risk;Risk Factors;Role;Route;Self Efficacy;skills;Speed;Structure;Task Performances;Telephone;Time;Training;Training Programs;Translating;Veterans;Walking;Writing

PROJECT_TITLE: Dual-Tasking for Individuals with Lower Limb Amputation: Exploring the Relationship to Falls and Instrumental Activities of Daily Living

STUDY_SECTION_NAME: Career Development Program - Panel II[RRD9]


ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Maternal immune activation (MIA) is a primer for long-term neuropsychiatric consequences in offspring, although the exact mechanisms underlying offspring neurodevelopmental defects resulting from these maternal immune insults are unknown. Here, we provide evidence that MIA-induced changes in the developing offspring’s extracellular chondroitin and dermatan sulfate glycosaminoglycan (CS/DS-GAG) sulfation patterning, which are key regulator of axonal guidance and synaptogenesis during neurodevelopment, may result in developmental defects that predispose the offspring to mental health disorders in the adult, and studies outlined within this proposal aim to further investigate this possibility.

PI_NAMEs: ALONGE, KIMBERLY MICHELE (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Acceleration;Adolescent;Adult;Affect;American;Anabolism;ATP phosphohydrolase;autism spectrum disorder;Axon;axon growth;axon guidance;axonal pathfinding;Behavior;Behavioral;Binding;Binding Proteins;Biochemical;Biological;Biology;biophysical properties;Bipolar Disorder;Brain;brain volume;cell motility;Chemicals;Childhood;Chondroitin Sulfate A;Chondroitin Sulfate C;Chondroitin Sulfates;Clinical Research;Code;Coupled;critical period;Cues;cytokine;Data;Defect;Dermatan Sulfate;dermatan sulfate chondroitin sulfate;Detection;Development;Disease;early childhood;Elements;Engineering;epidemiology study;Event;Exhibits;Exposure to;extracellular;Extracellular Matrix;fetal;Fiber;GAG Gene;Gene Expression;genetic signature;Growth Factor;High Fat Diet;Hippocampus;Hypersensitivity;Immune;immune activation;Impairment;Interneurons;Intervention;Isomerism;Lactation;laser capture microdissection;Length;Life;Link;Mass Spectrum Analysis;mechanotransduction;Mediating;Mediator;Mental Depression;Mental disorders;Mental Health;Methodology;Methods;Microglia;migration;Modeling;mother nutrition;Motor;multidisciplinary;Mus;nanopore;neurodevelopment;Neurodevelopmental Disorder;Neuroimmune;neuropathology;neuropsychiatric disorder;neuropsychiatry;nonhuman primate;novel;offspring;Patients;Pattern;Polymers;Polysaccharides;polysulfated glycosaminoglycan;postnatal;postnatal development;preclinical study;Pregnancy;prenatal;Prevalence;prevent;Prevention;Process;Proteins;regional difference;Regulation;Reporting;Resolution;response;Risk;Rodent;Schizophrenia;sensor;single molecule;spatiotemporal;Stimulus;Structure;Sulfate;synaptogenesis;Techniques;Technology;theories;translational potential;Zika Virus

PROJECT_TITLE: Maternal immune activation remodeling of offspring glycosaminoglycan sulfation patterns during neurodevelopment


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research

PHR: PROJECT NARRATIVE There is a national shortage of qualified clinician-scientists able to conduct the rigorous clinical research needed to address cardiovascular and pulmonary diseases. This training program proposes to continue to address this shortage through the efforts of a distinguished, experienced, and committed training program faculty. Training will continue to be provided to those who desire careers as clinician-scientists focusing on cardiology and pulmonary clinical research through a program that provides trainees with the skills needed to design, conduct, and complete epidemiologic studies that will address the most vexing population-based questions in cardiovascular and pulmonary medicine.

PI_NAMEs: CHRISTIE, JASON D (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TITLE: Cardiology and Pulmonary Clinical Research Training Program

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Pain Research;Prevention

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Project Narrative Genetic interactions govern the emergence of phenotype from genotype at every level, but our capacity to probe and decipher these interactions is severely limited. We will continue our hybrid computational and experimental effort to decipher the modular hierarchy of the mammalian cell, how interactions govern the relationships between modules, and how rewiring these relationships gives rise to disease states. Our development of next-generation multiplex CRISPR tools will extend the current state of the art and enable researchers worldwide to gain deeper insight into the complexity of the mammalian cell.

PI_NAMEs: HART, GLEN TRAVER (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Abdominal colic;Biological Assay;Biological Process;Biology;Buffers;Cell Line;Cells;Cellular biology;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Computer software;computer studies;computerized tools;CRISPR/Cas technology;Dependence;Development;Disease;disease model;endonuclease;experimental study;fitness;functional genomics;Future;Generations;Genes;Genetic;Genetic Predisposition to Disease;genome-wide;Genotype;Human;Hybrids;improved;insight;Internet;Knock-out;Libraries;Mammalian Cell;Maps;Measures;Mediating;multimodality;Mus;Mutation;Myeloid Leukemia;next generation;Normal Cell;novel;paralogous gene;Phenotype;Proliferating;Research;Research Personnel;Role;Saturated Fatty Acids;Screening for cancer;Shapes;Side;Suppressor Genes;Surveys;Technology;Tissues;Tumor Suppressor Proteins;Work

PROJECT_TITLE: Deciphering the hierarchical modularity of the mammalian cell through network integration and complex genetic perturbation strategies

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

PHR: PROJECT NARRATIVE 14-3-3θ phosphorylation at S232 is markedly elevated within insoluble fractions of human brains with synucleinopathy, including Parkinson’s Disease (PD) and Dementia with Lewy Bodies (DLB). We will examine the effect of 14-3-3θ phosphorylation in the pathophysiology of these disorders. Blockade of 14-3-3θ phosphorylation may serve as a potential therapeutic to reduce alpha-synuclein aggregation, neuroinflammation, and neurodegeneration in synucleinopathies.

PI_NAMEs: STONE, WILLIAM J (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Acceleration;aged;alpha synuclein;Area;Attenuated;Biological Assay;Brain;career;career development;Cell Death;Cells;Clinical;clinical application;Communication;Data;Dementia with Lewy Bodies;Dependovirus;Development;Disease;disorder risk;Doctor of Philosophy;dopaminergic neuron;Environment;Evaluation;Event;experience;Exposure to;Familiarity;Foundations;Functional disorder;Future;genetic manipulation;glial activation;Goals;Grant;ground water;Human;Immune;immunoreactivity;In Vitro;in vivo;in vivo Model;Industrialization;Interferon Type II;Knock-in;Knowledge;Laboratories;Lewy Bodies;Lewy body pathology;Lewy neurites;Literature;LRRK2 gene;Manuscripts;Mediating;Mediator;Mentors;Microglia;mimetics;Modeling;Molecular;Movement Disorders;Mus;mutant;Nerve Degeneration;Neuroblastoma;Neurodegenerative Disorders;neuroinflammation;Neurology;Neurons;neuroprotection;Neurosciences;Neurosciences Research;neurotoxic;neurotoxicity;Neurotoxins;nigrostriatal degeneration;Oral;overexpression;Oxidative Stress;Parkinson Disease;pars compacta;Pathogenesis;Pathologic;Phosphorylation;Physicians;precision medicine;Prevalence;prevent;Process;Protein Isoforms;Proteins;Rattus;Reporting;Research;research and development;Research Proposals;response;responsible research conduct;Rodent;Role;Scientist;Serine;Severities;Signal Induction;skill acquisition;skills;Solid;Solvents;Substantia nigra structure;synucleinopathy;Tamoxifen;Testing;Therapeutic;therapeutic gene;therapy development;Tissues;Toxic effect;Toxic Environmental Substances;Toxicant exposure;Training;translational approach;Translational Research;Trichloroethylene;United States National Institutes of Health;Variant;vector;virtual;volatile organic compound;Wild Type Mouse;Work;Writing

PROJECT_TITLE: Role of 14-3-3θ in Environmental Toxicant Exposure and Neuroinflammation in Synucleinopathies


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Skin Cancer

PHR: Project narrative: Giant congenital melanocytic nevi are very large birthmarks which produce increased probability of malignant melanoma formation, and therefore are commonly surgically removed in childhood, leaving major permanent morbidity over much of the body surface. In the current funding period, we generated four mouse models which allowed us to identify drug treatments that kill the nevus cells, including one that also displayed protection against melanoma. We propose studies to build on this progress, aiming to obtain treatment for this devastating childhood condition that can avoid a need for highly morbid permanently debilitating surgeries.

PI_NAMEs: FISHER, DAVID E (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Ablation;Acids;adaptive immunity;Agonist;Anguish;Animal Model;Anti-Inflammatory Agents;anti-PD-1;Binding;Body Surface;CD8-Positive T-Lymphocytes;CD8B1 gene;Child;Childhood;Childhood Melanoma;Clinical;Clinical Trials;Complement;Congenital melanocytic nevus;constitutive expression;Cutaneous;Deformity;Dermatology;Disease;Dose;effector T cell;Engineering;Esters;Excision;Exhibits;Funding;Genetic;Genetically Engineered Mouse;giant congenital nevus;Goals;Haptens;Histology;Human;human disease;Hyperpigmentation;Imiquimod;Immunity;immunodeficiency;Immunodeficient Mouse;Individual;inducible Cre;inducible gene expression;Infant;Inflammation;Inflammatory;inhibitor;Institutional Review Boards;kinase inhibitor;Kinetics;Laser injury;Lasers;Lesion;LoxP-flanked allele;Macrophage;Measurable;Medical;MEK inhibition;MEKs;melanocyte;Melanocytic Neoplasm;Melanocytic nevus;Melanoma;Melanosomes;Methods;Modeling;Modification;Morbidity - disease rate;mortality;mouse model;Mouse Strains;Mus;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Natural Immunity;Natural Killer Cells;neoantigens;Neoplasms;Nevus;Nevus Cell;Oncogenes;Operative Surgical Procedures;Peptides;Pharmacotherapy;Phase;PIK3CG gene;pre-clinical;Pre-Clinical Model;prevent;Prevention;Probability;promoter;Publishing;recruit;Regimen;Reporting;Reproducibility of Results;Resected;Risk;Schedule;senescence;SILV gene;Skin;skin lesion;Symptoms;T-Lymphocyte;Tamoxifen;Testing;Therapeutic;Tissues;Titrations;Topical application;Toxic effect;Transplantation;treatment strategy;Treatment-related toxicity;tumor;Visual;Xenograft procedure

PROJECT_TITLE: Therapeutic strategies for treatment of giant congenital melanocytic nevi

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: CHICAGO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Adjuvants incorporated into vaccine formulations have a major impact on vaccine efficacy via modulating and prolonging host immune responses. One-fourth of the world’s population is latently infected with Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), a leading infectious disease killer in the world. In the current proposal, we will develop the use of new adjuvants that drive Th1 responses and Th17 responses along with optimal Mtb antigens to significantly augment vaccine-induced protection against TB. The work proposed in this grant will thus result in a novel, first-of-kind rationally designed Th1 and/or Th17-inducing TB vaccine for use in humans in the near future.

PI_NAMEs: EVANS, JAY T.;KHADER, SHABAANA A. (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJALI

PROJECT_TERMS: Adjuvant;Adult;Aerosols;Agonist;Antigens;Bacille Calmette-Guerin vaccination;booster vaccine;Cells;Clinical Trials;Communicable Diseases;cytokine;Data;Development;Disease;Drug resistance;Drug resistant Mycobacteria Tuberculosis;efficacy evaluation;efficacy study;efficacy testing;efficacy validation;Evaluation;Funding;Future;Genetic;Grant;Health;Helper-Inducer T-Lymphocyte;high throughput technology;Human;Immune response;Immunity;immunogenicity;Inbred Mouse;Inbreeding;Interferon Type II;Interferons;Lead;lead candidate;lead optimization;Licensing;Lung;Macaca;Macaca mulatta;Mediating;Modeling;mouse model;mucosal vaccine;Mus;Mycobacterium bovis;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;nonhuman primate;novel;pathogen;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;Population;pre-clinical;Predisposition;prevent;Prevention;Production;protective efficacy;Pulmonary Tuberculosis;rational design;Recombinants;Resistance;resistant strain;response;Route;Safety;safety study;safety testing;single cell sequencing;T cell response;T-Lymphocyte;Testing;Th1 Cells;TLR7 gene;Tuberculosis;tuberculosis immunity;Tuberculosis Vaccines;vaccine candidate;vaccine efficacy;vaccine evaluation;vaccine formulation;vaccine immunogenicity;vaccine platform;Vaccine Production;vaccine response;vaccine safety;vaccine strategy;vaccine-induced immunity;Vaccines;Work

PROJECT_TITLE: Development of a novel adjuvanted Th1- and Th17-inducing subunit TB Vaccine


ORG_CITY: SAN FRANCISCO

ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

PHR: Rotator cuff tears are increasingly common in the aging population. Patients with a nonfunctional rotator cuff are difficult to elevate the arm to perform activities of daily living. With the aging of our veteran population, rotator cuff tears are becoming a more and more important health issue for the VA patients. The development of muscle fibrosis and fatty infiltration (FI) are critical factors that determine the clinical outcome of patients with this injury. However, there is no effective treatment for this disease at this time due to our limited understanding of the mechanisms. Successful achievement of this project will define how clinically relevant factors such as aging and tear size affect stem cell changes within the muscle. Results from this study may lead to new therapeutic approaches to treat this disease. Therefore, our proposal has particular significance for the VA population.

PI_NAMEs: FEELEY, BRIAN  (contact)

PROJECT_TERMS: Achievement;Activities of Daily Living;Address;Adipose tissue;Affect;Age;age related;age related changes;Aging;aging population;Agonist;American;Anterior;arm;Atrophic;cell motility;Cells;Chronic;Clinical;Clinical Research;clinically relevant;Disease;Economic Burden;effective therapy;endogenous stem cells;Fatty acid glycerol esters;Fibrosis;Future;Gene Expression;Gene Expression Profile;Health;Health Care Costs;Human;human data;human stem cells;Impairment;improved;In Vitro;in vitro regeneration;in vivo;in vivo Model;Infiltration;Injury;limb injury;Magnetic Resonance Imaging;medical attention;military veteran;Modeling;Mus;Muscle;muscle degeneration;Muscle Development;muscle progenitor cell;muscle regeneration;Muscular Atrophy;Natural regeneration;novel therapeutic intervention;older patient;Operative Surgical Procedures;Pathologic;patient population;Patient-Focused Outcomes;Patients;Phenotype;physically handicapped;Population;Process;Productivity;progenitor;Property;Quality of life;Recovery;regeneration potential;regenerative;repaired;response;Role;Rotator Cuff;rotator cuff tear;Source;stem cell genes;stem cell proliferation;stem cell self renewal;stem cells;supraspinatus muscle;surgery outcome;targeted treatment;Tendon structure;Time;Tissue Differentiation;tissue regeneration;Tissues;Translating;treatment strategy;Upper Extremity;Wages

PROJECT_TITLE: Endogenous stem cells promote regeneration of muscle in rotator cuff repair


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: HIV/AIDS remains a major threat to public health worldwide. Over the past three decades, Harvard faculty and their post-doctoral fellows supported by this training grant have made critical contributions to the progress in combating this epidemic that has come from research aimed at understanding the pathogenesis of HIV infection and its complications. The goal of this training program is to develop the next generation of scientific leaders poised to eliminate HIV/AIDS.

PI_NAMEs: KURITZKES, DANIEL R. (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;multidisciplinary;Training Programs

PROJECT_TITLE: Multidisciplinary AIDS Training Program

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]