NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Mental Health;Neurosciences;Radiation Oncology;Rare Diseases

PROJECT_TERMS: 18 year old;Algorithms;Biological Markers;Brain;brain magnetic resonance imaging;Brain Neoplasms;Clinical Trials;cognitive testing;cohort;Communication;Consensus;Cranial Irradiation;Data;Databases;design;Eligibility Determination;Evaluation;follow-up;gender difference;Histology;human subject;image archival system;Intravenous;Longitudinal Studies;Malignant Neoplasms;Measures;Metastatic malignant neoplasm to brain;MRI Scans;Neuropsychological Tests;Neuropsychology;Outcome;Outcome Measure;Pathologic;patient population;Patients;Performance;Primary Brain Neoplasms;Prognosis;prognostic;Protocols documentation;Quality of life;Questionnaires;Radiation;Radiation therapy;Radiation Therapy Oncology Group;radiomics;Radiosurgery;Sorting;Specimen;Standardization;Testing;treatment effect;United States National Institutes of Health

PROJECT_TITLE: Neuropsychological outcome measures in patients receiving whole brain radiation


ACTIVITY: ZIA

ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Orphan Drug;Precision Medicine;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_NAME: DIVISION OF BASIC SCIENCES - NCI

PI_NAMEs: KAPLAN, ROSANDRA  (contact)

PROJECT_TERMS: Adjuvant Therapy;Adult;aging process;Area;Behavior;Biological Assay;Biological Markers;Blood Vessels;bone circulation;Bone Marrow;cancer cell;cancer type;cell behavior;Cell Communication;Cell Compartmentation;Cell Lineage;Cell Therapy;cell type;Cells;chemotherapy;Chemotherapy and/or radiation;Childhood;chimeric antigen receptor T cells;Clinical;clinical translation;Clinical Trials;Collaborations;Complex;conventional therapy;Correlative Study;CXCR3 gene;Cytometry;Data;delivery vehicle;Development;Disease;Disseminated Malignant Neoplasm;Distant;Effectiveness;Endothelial Cells;endothelial stem cell;Endothelium;Engineering;Environment;epigenetic marker;Epigenetic Process;Equilibrium;Event;experimental study;Extracellular Matrix;Fibroblasts;fighting;Flow Cytometry;Gene Expression Profile;Genetic Engineering;Genetic Screening;Genetic Transcription;Growth;Growth and Development function;Heart Diseases;Hematopoietic;Hematopoietic stem cells;high risk;Human;Immune;immune phagocytosis;Immune response;Immune system;immunoregulation;Immunosuppression;Immunotherapy;improved;in vivo;individualized medicine;Inflammatory;insight;Interleukin-12;Investigation;Laboratories;life span;Liver;Longitudinal Studies;Lung;Malignant Neoplasms;Maps;Measures;Mediating;Mediator;Mesenchymal;Metabolic;metastatic process;microvesicles;Modeling;Molecular;Monitor;monocyte;mouse model;Multicellular Process;Mus;Mutation;Myelogenous;Myeloid Cells;Neoplasm Metastasis;neoplastic cell;Neuroblastoma;novel;Organ Transplantation;Osteosarcoma;Patients;Pericytes;Play;Population;potential biomarker;pre-clinical;preclinical study;predictive tools;Primary Neoplasm;Process;progenitor;prognostic tool;programs;receptor;recruit;Recurrent disease;Relapse;repaired;Research;response;Risk;Role;Shapes;Signal Transduction;single cell sequencing;Site;Solid Neoplasm;specific biomarkers;stem cells;Stromal Cells;System;T cell therapy;T-Lymphocyte;Testing;Therapeutic;therapeutic target;therapy design;timeline;tissue regeneration;tissue repair;transcriptomics;Translating;Translational Research;Transplant-Related Disorder;Treatment Efficacy;tumor;Tumor Immunity;Tumor Markers;tumor microenvironment;tumor progression;tumorigenesis;Universities;Vascular Diseases;Vascular Permeabilities;vesicular release;Work

PROJECT_TITLE: Biomarkers and Therapeutic Targets in Tumor Microenvironment and Metastasis


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Immunotherapy;Kidney Disease;Rare Diseases

PI_NAMEs: YANG, JAMES C (contact)

PROJECT_TERMS: Adoptive Transfer;Antigen Targeting;Antigens;CCR;Cells;Clone Cells;Cloning;Data;engineered T cells;Engineering;Freezing;Generations;Human;Immune;Immunotherapy;Malignant Neoplasms;Melanoma;Mutation;neoantigens;Normal tissue morphology;Patients;Proteins;Reagent;receptor;Renal Carcinoma;Renal Cell Carcinoma;Specificity;Specimen;T cell therapy;T-Cell Receptor;T-Lymphocyte;tool;tumor

PROJECT_TITLE: Generation of T-cell receptors recognizing antigens on non-melanoma tumors


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Immunotherapy;Liver Cancer;Liver Disease;Orphan Drug;Pancreatic Cancer;Patient Safety;Rare Diseases

PI_NAMEs: GRETEN, TIM  (contact)

PROJECT_TERMS: Cell Physiology;clinical center;Clinical Protocols;Conduct Clinical Trials;Correlative Study;experience;Gastrointestinal Neoplasms;hepatobiliary cancer;Immunotherapy;improved;improved outcome;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of pancreas;Malignant Neoplasms;Metastatic Neoplasm to the Liver;novel therapeutic intervention;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Research;Specimen;T-Lymphocyte;Treatment Efficacy;Treatment Protocols;United States National Institutes of Health;Work

PROJECT_TITLE: Clinical protocols for the treatment of gastrointestinal cancer


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Liver Disease

PROJECT_TERMS: Affect;Cell Physiology;Cells;clinical center;Conduct Clinical Trials;Correlative Study;Goals;Immune;improved;Liver;Malignant neoplasm of gastrointestinal tract;Metastatic Neoplasm to the Liver;novel;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Primary Neoplasm;Research;Sampling;Specimen;T-Lymphocyte;therapy outcome;Treatment Efficacy;tumor;tumor microenvironment;United States National Institutes of Health;Work

PROJECT_TITLE: Immune suppressor mechanisms in patients with GI cancer


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Immunotherapy;Liver Disease;Microbiome

PROJECT_TERMS: Affect;Cell Physiology;Cells;Cirrhosis;effective therapy;Environment;fatty liver disease;Frequencies;Genetic;Immune;Immunologic Surveillance;Immunologics;Immunosuppressive Agents;Infection;Inflammation;Liver;Liver diseases;Malignant Neoplasms;microbiome;Mucous Membrane;Mus;novel;Phenotype;Regulatory T-Lymphocyte;Research;T-Lymphocyte;Tumor Escape;tumor growth;Tumor Immunity

PROJECT_TITLE: Analysis of cancer-related immune suppressor mechanisms in mice


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Orphan Drug;Rare Diseases;Urologic Diseases

PI_NAMEs: APOLO, ANDREA  (contact)

PROJECT_TERMS: Adjuvant Study;anti-PD-L1;Area;bladder transitional cell carcinoma;Cancer Etiology;Cessation of life;Clinical;Cystectomy;Disease;first-in-human;High Prevalence;high risk;Human;IgG1;Immune checkpoint inhibitor;Immunotherapy;improved;improved outcome;inhibiting antibody;Ligands;Malignant neoplasm of urinary bladder;Malignant Neoplasms;men;Modality;Muscle;novel therapeutics;Pathway interactions;Patients;PD-1/PD-L1;pembrolizumab;Phase III Clinical Trials;Principal Investigator;programmed cell death ligand 1;programmed cell death protein 1;programs;Randomized;Reporting;Research;response;Somatic Mutation;targeted agent;Testing;Transitional Cell Carcinoma;treatment choice;Treatment outcome;tumor;tumor microenvironment;Tumor-Infiltrating Lymphocytes;United States;United States Food and Drug Administration;Urothelium;Woman

PROJECT_TITLE: Bladder Cancer Program


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Precision Medicine;Rare Diseases

PI_NAMEs: WILSON, WYNDHAM H (contact)

PROJECT_TERMS: Address;Apoptosis;B-Cell Antigen Receptor;B-Cell Lymphomas;BCL2 gene;Cell Line;Clinical;Collaborations;cytotoxic;Dose;Dose Limiting;Dose Rate;Follicular Lymphoma;Genetic;improved outcome;Individual;IRF4 gene;large cell Diffuse non-Hodgkin's lymphoma;lenalidomide;Malignant lymphoid neoplasm;Mantle Cell Lymphoma;Modeling;neoplastic cell;NF-kappa B;Pathway interactions;Patients;phase 2 study;Randomized;Receptor Signaling;Refractory;Regimen;Regulation;Relapse;resistance mechanism;response;Safety;Schedule;Stratification;targeted agent;targeted treatment;Toxic effect

PROJECT_TITLE: Targeted treatment of B-cell Lymphoma


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Radiation Oncology;Rare Diseases

PI_NAMEs: TOFILON, PHILIP  (contact)

PROJECT_TERMS: Adherent Culture;Biology;Brain;Cell Line;Cells;Cues;Data;Diagnosis;Disease;DNA Damage;Environment;established cell line;Evolution;fractionated radiation;Funding;Future;Gene Expression;Gene Expression Profile;Genes;genome-wide;Genotype;Glioblastoma;Glioma;Goals;Growth;Human;improved;In Situ;In Vitro;in vivo;insight;Investigation;Laboratories;Leg;Mediating;Molecular;Molecular Target;neglect;neoplastic cell;novel;novel strategies;Patients;Pattern;Phenotype;Pre-Clinical Model;Process;Proteins;Protocols documentation;Radiation;Radiation Protection;radiation resistance;Radiation therapy;Radiation Tolerance;Radiation-Induced Gene Expression;Radiobiology;radioresistant;Radiosensitization;Recurrence;Regulation;Research;response;Role;SLC12A3 gene;Source;stem-like cell;targeted agent;Testing;transcriptome;Translations;treatment response;Tumor Cell Line;tumor heterogeneity;tumor xenograft;Xenograft procedure

PROJECT_TITLE: Microenvironmental regulation of glioblastoma radiosensitivity


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Radiation Oncology;Rare Diseases

PROJECT_TERMS: Affect;Alternative Splicing;Area;Arginine;Binding;Biogenesis;cancer site;Cell Physiology;Cell Survival;cell type;Characteristics;Clinical Trials;clinically relevant;Data;defined contribution;Evaluation;Event;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;genome-wide;Goals;Histology;Human Genome;inhibitor;Investigation;Ionizing radiation;irradiation;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant neoplasm of central nervous system;Malignant Neoplasms;Measures;Mediating;Messenger RNA;Microarray Analysis;MicroRNAs;Modification;mRNA Precursor;mRNA Translation;neoplastic cell;Nervous System;Neurosciences Research;Normal Cell;novel;Phosphotransferases;Polyribosomes;Post-Transcriptional Regulation;posttranscriptional;Predisposition;Process;Proteins;Radiation;radiation effect;Radiation therapy;Radiation Tolerance;Radiation-Induced Change;Radiation-Sensitizing Agents;Radiosensitization;Research;Ribosomal DNA;Ribosomes;RNA Helicase;RNA Polymerase I;RNA Splicing;RNA-Binding Proteins;Role;Serine;small molecule;Source;Specificity;Testing;Translations;translatome;tumor;Tumor Cell Line

PROJECT_TITLE: Radiation-induced translational control of gene expression


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: BARR, FREDERIC  (contact)

PROJECT_TERMS: 12q13;13q14;1p36;3' Untranslated Regions;Behavior;Binding;Binding Sites;Biological;Biological Assay;Candidate Disease Gene;candidate identification;Cell Culture System;Cell Line;Cells;Chemicals;Childhood;Complementary DNA;CRISPR/Cas technology;design;directed attention;Doxycycline;Event;experimental study;FOXO1A gene;fusion gene;Gene Amplification;Gene Chips;gene interaction;Genes;Genetic Complementation Test;Genetic Heterogeneity;Genetic Transcription;genome-wide;Genomics;Goals;Growth;Human;Immunohistochemistry;Individual;Malignant Neoplasms;Maps;MicroRNAs;Molecular;Monitor;Mus;MYCN gene;Myoblasts;NIH 3T3 Cells;Oncogenic;Oncoproteins;overexpression;Pathogenesis;Pathway interactions;PAX3 gene;PAX7 gene;Phenotype;Population Growth;Porifera;Process;Proteins;Reagent;Recurrence;Reporter Genes;research study;Rhabdomyosarcoma;RNA;RNA Interference;Role;soft tissue;targeted treatment;Testing;Therapeutic Intervention;therapeutic target;Tissue Microarray;transcriptome sequencing;tumor;tumorigenesis;Untranslated RNA;Up-Regulation;Western Blotting;Work

PROJECT_TITLE: Studies of amplification in rhabdomyosarcoma


NIH_SPENDING_CATS: Cancer;Genetics

PI_NAMEs: SINGER, DINAH S. (contact)

PROJECT_TERMS: 3-Dimensional;Acetylation;Adopted;Affinity;Architecture;Binding;Biochemical;biophysical properties;Biophysics;Bromodomain;C-terminal;Cancer Etiology;Cell Cycle Progression;Chromatin;Chromatin Structure;Clinical;Collaborations;Communities;Cryoelectron Microscopy;Data Set;dimer;Dimerization;Disease;DNA Polymerase II;Elements;Enhancers;Epithelium;experimental study;flexibility;Genetic Transcription;Goals;Histones;Immunology;immunoregulation;In Vitro;in vivo;insight;interest;Laboratories;Length;Libraries;Malignant Neoplasms;Mesenchymal;Molecular;Molecular Conformation;MYC Family Protein;N-terminal;Natural Products;Neoplasm Metastasis;Nuclear;Nut carcinoma;Phase;Phosphotransferases;Physical condensation;Play;Post-Translational Protein Processing;Proteins;recruit;Research;Roentgen Rays;Role;Scanning;small molecule;Structure;therapeutic target;three dimensional structure;Transcription Elongation;transcription factor;Transcriptional Regulation;Transferase;Virus Diseases

PROJECT_TITLE: Brd4 is an atypical kinase that regulates transcription


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: LARSON, DANIEL  (contact)

PROJECT_TERMS: 3' Splice Site;Alternative Splicing;Behavior;Binding;Binding Sites;Biophysics;Bone Marrow;Cell Nucleus;Cell Physiology;Cells;Complex;Computer Models;Cytoplasm;Disease;Dysmyelopoietic Syndromes;Eukaryotic Cell;Gene Expression;Gene Expression Regulation;Genetic Transcription;Genomic approach;Goals;Health;helicase;Hematopoiesis;Image;In Vitro;in vivo;Individual;Introns;kinetic model;Kinetics;Laboratories;macromolecule;Messenger RNA;Metabolic;Microscopy;Mitochondria;mitochondrial genome;mitochondrial messenger RNA;Mitochondrial Proteins;Modeling;Molecular;Molecular Target;mRNA Precursor;Nuclear;Oncogenic;Outer Mitochondrial Membrane;Patients;Pattern;Point Mutation;Population;Process;progenitor;Proteins;Regulation;Research;RNA;RNA Splicing;RNA-Binding Proteins;Role;Signal Transduction;single molecule;Site;Spliceosomes;Structure;Tissues;transcriptome sequencing;Translational Repression;Translations;Variant;Visualization;Work

PROJECT_TITLE: Transcription and Splicing Dynamics in Single Cells


PROJECT_TERMS: Animals;Biological Assay;Candidate Disease Gene;cDNA Expression;Cell Culture System;Cell Culture Techniques;Cell Line;Cells;Childhood;Chimeric Proteins;Collaborations;CRISPR/Cas technology;Cultured Cells;Dependence;Development;Doxycycline;Event;Excision;experimental study;FOXO1A gene;fusion gene;Fusion Oncogene Proteins;Gene Fusion;Gene Targeting;Genes;genetic analysis;Genetic study;Genetic Transcription;genome-wide;Goals;Growth;Heterogeneity;Human;In Vitro;in vivo;knock-down;Knock-out;Laboratory mice;Maintenance;Malignant Neoplasms;Methodology;Modeling;Molecular;MYC Family Protein;MYCN gene;Myoblasts;N-Myc Protein;Neoplasm Metastasis;neoplastic cell;novel;Oncogenes;Oncogenic;Oncoproteins;Pathogenicity;Pathway interactions;Patients;PAX3 gene;Pharmacology Study;Phenotype;Point Mutation;Population;Primary Neoplasm;protein expression;Proteins;Recurrence;Recurrent tumor;resistance mechanism;Rhabdomyosarcoma;Role;soft tissue;Study models;System;targeted treatment;Testing;transcription factor;tumor;tumor progression;Tumor-Derived;tumorigenesis;tumorigenic;Variant

PROJECT_TITLE: Studies of gene fusions in rhabdomyosarcoma


PI_NAMEs: HU, YINLING  (contact)

PROJECT_TERMS: Adenocarcinoma;Amphiregulin;anti-PD-1;anti-PD1 antibodies;Antibody Therapy;Cancer Etiology;Cancer Patient;carcinogenesis;CD4 Positive T Lymphocytes;Cessation of life;CSF1R gene;Development;Disease;Epidermal Growth Factor Receptor;Epithelial Cells;Exclusion;Foamy Macrophage;Genes;Human;IKK alpha;IL4R gene;Immunotherapy;improved;Inflammation;Inflammatory;inhibitor;Interleukin-4;KRAS2 gene;Link;lipid metabolism;Lipids;Lung;Lung Adenocarcinoma;Macrophage;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Metabolic;migration;Modeling;Motility;mouse model;Mus;Mutant Strains Mice;nutrition;Patients;Phosphotransferases;Prevention;Production;programmed cell death protein 1;Reporting;Role;Signal Transduction;Smoker;Squamous Cell Lung Carcinoma;STAT6 gene;Sterol O-Acyltransferase;TP53 gene;United States

PROJECT_TITLE: Role of IKK alpha in lung cancer development


NIH_SPENDING_CATS: Cancer

PI_NAMEs: WESTLAKE, CHRISTOPHER  (contact)

PROJECT_TERMS: 3-Dimensional;Affect;AKT Signaling Pathway;Animal Model;Apical;Architecture;Binding;Biochemistry;Biophysics;Brain;cancer cell;cell assembly;Cell Culture Techniques;Cell Line;Cell membrane;Cell surface;cell type;Cells;cellular imaging;Cellular Membrane;Centrioles;Cilia;ciliopathy;cilium biogenesis;cilium motility;Collaborations;Communicable Diseases;Communication;Complex;CRISPR/Cas technology;Defect;Development;Disease;disease-causing mutation;Docking;Electron Microscopy;Embryo;Endocrine System Diseases;Epithelial Cells;Erinaceidae;extracellular;Extracellular Space;Family;Female;Fibroblasts;Fishes;Fluorescence;fluorescence imaging;Fluorescence Microscopy;Functional disorder;gain of function;Genetic Diseases;Goals;Growth;Health;Homeostasis;Human;human disease;Human Genetics;imaging approach;Impairment;interdisciplinary approach;Investigation;Knock-out;Laboratories;Link;Lung;Malignant Neoplasms;Manuscripts;Membrane;Mesenchymal;Microscopy;Microtubules;Modeling;Molecular;Monomeric GTP-Binding Proteins;Mothers;Motility;Movement;Mus;Nature;Nervous System Disorder;Neurites;notch protein;Organelles;Paper;Pathway interactions;Photoreceptors;Physiological;PIK3CG gene;Platelet-Derived Growth Factor;Play;Postdoctoral Fellow;Preparation;prevent;Process;Proteomics;Publishing;Pythons;Rana;recruit;Regulation;Reporting;Repression;reproductive function;Research;Role;Signal Transduction;Signal Transduction Pathway;Structure;Subcellular structure;Testing;Time;tool;trafficking;tumorigenesis;ultra high resolution;Universities;Variant;Vesicle;Work;Xenograft procedure

PROJECT_TITLE: Regulation of Ciliogenesis and Ciliary-related signaling


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Kidney Disease

PI_NAMEs: MERINO, MARIA  (contact)

PROJECT_TERMS: Cell Survival;Clear cell renal cell carcinoma;Clinical;Development;Diagnosis;Disease Outcome;Gene Expression Regulation;Goals;Histologic;Human;human disease;Inherited;Kidney Neoplasms;Link;liquid biopsy;Malignant Neoplasms;MicroRNAs;miRNA expression profiling;Molecular Classification of Tumors;novel marker;Oncogenes;Patients;Phylogenetic Analysis;Play;Post-Transcriptional Regulation;potential biomarker;Proliferating;Regulation;Renal Carcinoma;Role;Small RNA;Testing;tumor;Tumor Suppressor Genes;tumorigenesis;Urine;VHL Gene Inactivation

PROJECT_TITLE: microRNA Profiling in the Spectrum of Kidney Tumors


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Gene Therapy;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PI_NAMEs: KOCHENDERFER, JAMES  (contact)

PROJECT_TERMS: Allogenic;B lymphoid malignancy;B-Cell Leukemia;Blood;CD19 gene;Cell Transplantation;Cells;cellular transduction;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical Oncology;Clinical Trials;Collaborations;Donor person;engineered T cells;experimental study;Extramural Activities;Goals;Hematopoietic Stem Cell Transplantation;HLA Antigens;Homologous Transplantation;Human Biology;in vivo;Infusion procedures;Journals;Learning;leukemia/lymphoma;Malignant Neoplasms;Memory;Molecular;Patients;professor;Proliferating;Proteins;Publications;Publishing;Relapse;Research Personnel;stem;Stem cell transplant;T cell therapy;T memory cell;T-Lymphocyte;Testing;Work

PROJECT_TITLE: Allogeneic T cells Transduced with an Anti-CD19 Chimeric Antigen Receptor


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

PROJECT_TERMS: Adoptive Transfer;anti-CD20;Antigens;B cell therapy;B lymphoid malignancy;B-Cell Lymphomas;B-Lymphocytes;Biological;CD19 gene;chimeric antigen receptor;chimeric antigen receptor T cells;Chronic Lymphocytic Leukemia;chronic T-cell leukemia;Clinical Trials;curative treatments;cytokine;design;Effectiveness;Enrollment;FDA approved;Gene Modified;genetically modified cells;Human;improved;Infusion procedures;large cell Diffuse non-Hodgkin's lymphoma;leukemia/lymphoma;Lymphoma;Membrane;Methods;MS4A1 gene;novel therapeutics;Paper;Patients;pre-clinical;Principal Investigator;Production;Publishing;T-Cell Receptor Therapy;T-Lymphocyte;Testing;Toxic effect

PROJECT_TITLE: Improved Chimeric Antigen Receptor Therapies B-cell Malignancies


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Esophageal Cancer;Genetics;Human Genome;Lung;Lung Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Tobacco;Tobacco Smoke and Health

PI_NAMEs: SCHRUMP, DAVID  (contact)

PROJECT_TERMS: airway epithelium;Antibody Specificity;Asbestos;ASCL1 gene;ATAC-seq;Bioinformatics;Bromodomain;Bromodomains and extra-terminal domain inhibitor;cancer cell;Cancer Patient;cancer stem cell;cancer therapy;carcinogenesis;Cells;ChIP-seq;Chromatin;Chromosome 18;Chromosome Mapping;Chromosomes;cigarette smoke;cigarette smoking;Comb animal structure;Complex;Data;deep sequencing;Deoxyribonuclease I;Deoxyribonucleases;Development;digital;Disease;Distant;DNA;DNA Methylation;DNA replication origin;Enhancers;Environmental Carcinogens;Epigenetic Process;epigenomics;Epithelial Cells;Esophageal Adenocarcinoma;esophageal carcinogenesis;Esophageal Squamous Cell;esophageal squamous cell cancer;Esophagus;Event;Exhibits;experimental study;Exposure to;Fiber;Frequencies;G1/S Transition;Gene Expression Profile;Gene Expression Regulation;gene repression;gene synthesis;Genes;genetic signature;genome-wide;Genomics;glucose metabolism;Growth;Human;Hypersensitivity;Impairment;In Vitro;in vitro Model;in vivo;induced pluripotent stem cell;insight;Journals;knock-down;Knock-out;Legal patent;Length;Link;Lung;lung cancer cell;Malignant neoplasm of esophagus;Malignant neoplasm of lung;Malignant neoplasm of thorax;Malignant Neoplasms;Malignant Pleural Mesothelioma;Manuscripts;Maps;Mediating;Mediator;meetings;Metastatic Neoplasm to the Liver;methylome;Modeling;Mus;Neoplasm Metastasis;Neoplasms;new therapeutic target;NFIC gene;Non-Small-Cell Lung Carcinoma;Normal Cell;novel;novel strategies;Oral;Organ;overexpression;Pathway interactions;patient derived xenograft model;Patients;Peer Review;pluripotency;Polycomb;Prevention;Promoter Regions;Protein Family;Proteins;Publishing;Regulatory Element;Reporting;Repression;Reproducibility;Research;Role;S phase;Sampling;sex;Signal Transduction;Site;Specificity;Specimen;Speed;stem;stem cell model;stem cells;stemness;Surgical Oncology;symposium;Testis;therapy resistant;Thoracic Oncology;Thoracic Surgical Procedures;Time;Tobacco;Transcriptional Regulation;transcriptome;treatment strategy;ubiquitin isopeptidase;Up-Regulation;virtual

PROJECT_TITLE: Modulating Cancer Stem Cell Signaling in Thoracic Malignancies


NIH_SPENDING_CATS: Cancer;Eye Disease and Disorders of Vision;Rare Diseases

PI_NAMEs: BYRD, ROBERT  (contact)

PROJECT_TERMS: ADP-Ribosylation Factors;Attention;Basic Science;Biophysics;Clinical Sciences;Collaborations;collaborative approach;Complex;Family;GTP-Binding Proteins;GTPase-Activating Proteins;In Situ;insight;interest;Investigation;Knowledge;Malignant Neoplasms;Membrane;Membrane Proteins;Molecular Biology;molecular dynamics;Monomeric GTP-Binding Proteins;multidisciplinary;Multiprotein Complexes;Mutation;Neutrons;NMR Spectroscopy;novel therapeutic intervention;Pathway interactions;protein complex;Protein Family;Proteins;Publishing;Research;Research Personnel;Signal Transduction;structural biology;Structural Models;Surface;tool;Uveal Melanoma

PROJECT_TITLE: Structural Biology of GTPase Activating Proteins


PROJECT_TERMS: Cancer Model;CD4 Positive T Lymphocytes;Cell Count;Cells;Development;FOXP3 gene;Human;IKK alpha;immune cell infiltrate;Immunotherapy;Infiltration;Lung Adenocarcinoma;lymphoid organ;Macrophage;Oncogenic;organ growth;Pathway interactions;Pattern;Play;Regulatory T-Lymphocyte;Role;T-Cell Development;T-Lymphocyte;targeted cancer therapy;tumor;tumor microenvironment;tumorigenesis

PROJECT_TITLE: Role of IKK alpha in lymphoid organ development


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Fetal Tissue;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases

PROJECT_TERMS: 13q;Alveolar;Architecture;bead chip;Biological;Body Regions;Categories;Cells;Childhood;Childhood Rhabdomyosarcoma;Chromatin;chromosome 8 gain;Classification;Clinical;clinically significant;cohort;Collaborations;Data;density;Development;DICER1 gene;DNA Methylation;DNA methylation profiling;Embryonal Rhabdomyosarcoma;Engineering;Epigenetic Process;Etiology;Event;Family;FGFR4 gene;Fibronectins;FOXO1A gene;Freezing;Gene Fusion;Genes;Genetic Transcription;genome wide methylation;genome-wide;genome-wide analysis;Genomic DNA;Goals;Heterogeneity;Histology;Hypermethylation;Malignant Neoplasms;Methylation;methylation pattern;Molecular;mouse model;Mutation;MYCL1 gene;NF1 gene;Oncogenic;Other Genetics;Outcome;Pathologic;Pathway interactions;Pattern;PAX3 gene;PAX7 gene;Point Mutation;Principal Component Analysis;promoter;Promoter Regions;Publishing;RAS Family Gene;Ras Signaling Pathway;Recurrence;Rhabdomyosarcoma;Sampling;Sarcoma;Skeletal Muscle;soft tissue;Tissue-Specific Gene Expression;Tissues;TP53 gene;tumor;Tumor-Derived

PROJECT_TITLE: Epigenetic studies in rhabdomyosarcoma


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Hematology;Human Genome;Immunotherapy;Lymphatic Research;Lymphoma;Neurofibromatosis;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases;Skin Cancer;Women's Health Research

PI_NAMEs: MIETTINEN, MARKKU  (contact)

PROJECT_TERMS: Adenocarcinoma;Affinity;Antigens;beta catenin;Biology;Brachyury protein;Childhood;Choriocarcinoma;Chromosome Mapping;Classification;Clinical;clinical diagnosis;Clinical Markers;clinically significant;Collaborations;Colon Carcinoma;CTNNB1 gene;Development;Diagnostic;diagnostic biomarker;Elements;Epithelium;gastrointestinal;gastrointestinal carcinoma;Gastrointestinal Stromal Tumors;Gene Fusion;Genetic;Genetic Diseases;Genomics;Germ cell tumor;Goals;hemangiopericytoma;Histologic;Hodgkin Disease;Immunotherapy;insight;Ki-1 Large-Cell Lymphoma;Laboratories;Large-Cell Lymphomas;Lymphoma cell;Malignant Childhood Neoplasm;Melanoma;member;Mesenchymal Cell Neoplasm;Methylation;Mismatch Repair Deficiency;Mutation;Myofibroblastomas;Nerve;Neuroendocrine Tumors;neurofibroma;Neurofibromatosis 1;Non-Cutaneous Melanoma;Nose;novel diagnostics;NTRK1 gene;NTRK3 gene;Nuclear;Paraganglioma;Pathology;Patients;Pediatric Oncology;Peripheral Nerve Sheath Neoplasm;Placenta;placental trophoblasts;Probability;Prognostic Marker;programmed cell death ligand 1;Protocols documentation;Research Personnel;Research Support;Retroperitoneal Space;Sarcoma;Schwann Cells;Signs and Symptoms;Site;Soft Tissue Neoplasms;Soft tissue sarcoma;Squamous cell carcinoma;Tissues;Trophoblastic Neoplasms;tumor;Tumor Biology;tumor progression;United States National Institutes of Health

PROJECT_TITLE: Immunohistochemical and genomic analysis of tumors


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Cancer;Multiple Sclerosis;Neurodegenerative;Neurosciences

PI_NAMEs: LAZAREVIC, VANJA  (contact)

PROJECT_TERMS: Autoantigens;Autoimmune;Autoimmunity;autoreactivity;Cells;CNS autoimmune disease;Development;Experimental Autoimmune Encephalomyelitis;Gene Expression Profile;Genetic Transcription;IL17 gene;Infiltration;Inflammation;Laboratories;Mediating;Modeling;Mus;neuroinflammation;Organ;Pathogenesis;Pathogenicity;Pathology;Research;Role;Systems Biology;Tissues;transcription factor;Work

PROJECT_TITLE: Role of T-bet in the pathogenesis of experimental autoimmune encephalomyelitis


NIH_SPENDING_CATS: Bioengineering;Cancer

PI_NAMEs: TANNER, KANDICE  (contact)

PROJECT_TERMS: 3-Dimensional;Adhesions;Adopted;Adult;Animals;Architecture;Biochemical;Biological;Biomimetics;Biophysics;Blood flow;Brain;Breast;cancer cell;Cardiovascular system;Cell Shape;Cells;Complex;Cues;Distant;Distant Metastasis;Ecology;Endothelium;Environment;Exhibits;experience;extracellular;Extracellular Matrix;Extravasation;Gene Expression;Generations;Genetic Variation;Glioblastoma;Habitats;human model;Hydrogels;Impairment;in vivo;insight;Liquid substance;Lung;Malignant Neoplasms;Maps;Measures;mechanical properties;mechanical signal;Mechanics;Neoplasm Metastasis;neoplastic cell;Normal Cell;optic trap;optical traps;Organ;Penetration;Phenotype;physical property;pressure;Primary Neoplasm;Property;Research;response;Rheology;Role;Rotation;Signal Transduction;Site;System;Techniques;Testing;three dimensional cell culture;Tissues;tumor;tumor progression;viscoelasticity;Zebrafish

PROJECT_TITLE: The Role of Coherent Rotation in Adult Tissue Remodeling


PI_NAMEs: PATHAK, VINAY K. (contact)

PROJECT_TERMS: Academy;Atomic Force Microscopy;Binding;Biological Assay;Capsid;Categories;Cell division;Cell Nucleus;Cells;Chromatin;Complex;Consumption;Cytoplasm;DNA;DNA Integration;Docking;ds-DNA;Enzymes;Exhibits;Fluorescent in Situ Hybridization;Genes;Genetic Transcription;Genome;Goals;Green Fluorescent Proteins;HIV-1;Host Defense;Image;In Situ;Infection;insight;Integration Host Factors;integration site;Kinetics;Label;live cell microscopy;Location;Mammalian Cell;Methods;Modeling;Molecular;Movement;Nuclear;Nuclear Envelope;Nuclear Import;Nuclear Pore;Nuclear Pore Complex;Nucleocapsid Proteins;NUP98 gene;Paper;Phase;Physical condensation;Play;Prize;Process;Proteins;Proviruses;Publications;Publishing;quantitative imaging;residence;Retroviridae;Reverse Transcription;RNA;RNA-Directed DNA Polymerase;Role;Science;Site;Structure;Target Populations;Time;Transcriptional Activation;Travel;United States;Viral;viral DNA;Virus Integration;Virus Replication;whole genome;Work

PROJECT_TITLE: Viral Replication and Interactions with Host Factors


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Hematology;Immunotherapy;Rare Diseases

PROJECT_TERMS: antigen binding;Antigen Targeting;Antigens;B-Lymphocytes;Binding;cancer cell;CAR T cell therapy;Cell Maturation;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clinical Trials;Collaborations;design;Development;Family member;follow-up;Genetic Engineering;Goals;Human;Industry;Laboratory Study;Malignant Neoplasms;Medicine;Molecular;Multicenter Trials;Multiple Myeloma;Mus;Nature;novel;Paper;participant enrollment;Patients;phase I trial;Progression-Free Survivals;Publishing;Refractory;Relapse;Remission Induction;response;SLAM protein;T-Lymphocyte;Testing;Time;trial enrollment;Universities

PROJECT_TITLE: Development of Chimeric Antigen Receptors Targeting Multiple Myeloma


PI_NAMEs: LONCAREK, JADRANKA  (contact)

PROJECT_TITLE: Control of centrosome biogenesis


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cancer;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Kidney Disease;Prevention;Vaccine Related

PI_NAMEs: BUCK, CHRISTOPHER  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;Adult;Animal Model;Antibodies;Antibody Response;Antigens;BK Virus;Brain Diseases;Capsid Proteins;Chronic;Clinical;Colorectal Cancer;Development;Disease;Genotype;Goals;Human;human monoclonal antibodies;Human Papillomavirus;Humoral Immunities;Immunocompromised Host;Immunosuppressive Agents;India;Individual;Industry;industry partner;Infection;Injection product;invention;JC Virus;Kidney Diseases;Kidney Transplantation;Legal patent;Lesion;Licensing;Link;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mediating;Mus;neutralizing antibody;novel;Oral;Pathology;Patients;Phase I/II Clinical Trial;Play;Polyomavirus;Polyomavirus Infections;pressure;prevent;Preventive vaccine;Progressive Multifocal Leukoencephalopathy;recombinant virus;renal damage;Resistance;Risk;Role;Route;Serotyping;Serum;Symptoms;System;Therapeutic immunosuppression;tool;Transplant Recipients;Urinary tract;Urine;Vaccination;vaccine development;Vaccines;Variant;Viral;Virion;Virus;virus development;Virus-like particle;Viviparous-1 protein;Work

PROJECT_TITLE: BKV and JCV vaccine development


NIH_SPENDING_CATS: Cancer;HIV/AIDS;Infectious Diseases

PI_NAMEs: KEWALRAMANI, VINEET N (contact)

PROJECT_TERMS: Affect;anti-cancer;Anti-viral Therapy;Biology;C-terminal;Capsid;Cells;chimeric antigen receptor T cells;Chimeric Proteins;Chromatin;Cyclophilin A;gene therapy;Gene Transduction Agent;Genome;HIV-1;Human;improved;Infection;Integration Host Factors;Lentivirus Vector;Maps;Mediating;migration;N-terminal;Nuclear;Nuclear Pore Complex;Nuclear Pore Complex Proteins;Play;Process;Protein Analysis;Protein Isoforms;Proteins;Regulation;Role;Surface;TRIM5 gene;Virus;X-Ray Crystallography

PROJECT_TITLE: The role of POM121 in HIV-1 infection


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Prevention;Vaccine Related

PI_NAMEs: MALDARELLI, FRANK  (contact)

PROJECT_TERMS: Adverse effects;Affect;Anatomy;Angiolymphoid hyperplasia;Anti-Inflammatory Agents;Antibiotics;Antigens;Antineoplastic Agents;antiretroviral therapy;Award;Bacterial Translocation;Binding;Biopsy;Blinded;Blood;Blood - brain barrier anatomy;candidate identification;CCR;CD4 Positive T Lymphocytes;Cells;Central Nervous System;chemotherapy;chimeric antigen receptor T cells;Clinical;clinical effect;Clinical Protocols;Clinical Research;Clonal Expansion;co-infection;Collaborations;comorbidity;Comparative Study;Cryptococcal Meningitis;Data;design;Disease;driving force;Event;experience;fluorodeoxyglucose;gastrointestinal;Goals;gut microbiome;HIV;HIV Infections;HIV therapy;HIV vaccine;HIV/AIDS;immune activation;immune reconstitution;Immune response;Immunologics;Immunomodulators;in vivo;Individual;Infection;Inflammatory;Integration Host Factors;Interferon Alfa-2b;interferon therapy;Interferons;Interruption;Intervention;Intervention Studies;Interventional radiology;Kaposi Sarcoma;Location;Long-Term Effects;lymph nodes;Lymphoid Tissue;Lymphoma;Metabolic;microbiome;Minnesota;multidisciplinary;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;Natural Immunity;neoplastic;non-invasive imaging;Peripheral Blood Lymphocyte;Phylogenetic Analysis;Plasma;Population;Positron-Emission Tomography;prevent;Primates;Production;Progressive Multifocal Leukoencephalopathy;Protocols documentation;Randomized;Regimen;Research Personnel;Resistance;response;Retrovirology;rifaximin;Role;Sampling;SARS-CoV-2 infection;Series;Shapes;Site;Source;Squamous cell carcinoma;Structure;Syndrome;Therapeutic;therapeutic vaccine;Time;Tuberculosis;United States National Institutes of Health;uptake;Vaccination;vaccine trial;Vaccines;Viral;Viremia;Virus

PROJECT_TITLE: Clinical Interventional Studies of HIV Reservoirs


PI_NAMEs: LEVENS, DAVID L. (contact)

PROJECT_TERMS: Affect;Amplifiers;Apoptosis;Biochemical;c-myc Genes;cancer cell;carcinogenesis;CCR;Chromatin;Code;Complex;coping;Coupled;CRISPR screen;design;DNA;DNA Damage;Equilibrium;Event;Fiber;Gene Expression;Genes;Genetic;Genetic Transcription;genome integrity;Growth;Human;In Vitro;Intercept;Investigation;Knock-in Mouse;Malignant Neoplasms;Mechanical Stress;Metabolism;Methods;Molecular;Molecular Conformation;Mutation;MYC gene;Normal Cell;novel;Nuclear;Oncogenes;Oncogenic;Output;Pathologic;Pathologic Processes;Pathway interactions;Phase;Physical condensation;Physiological;Physiological Processes;preservation;Process;Proliferating;promoter;protein function;Proteins;Proto-Oncogenes;Regulation;replication stress;System;Tissues;Topoisomerase;TP53 gene;Transcription Coactivator;Transcription Process;Transcriptional Activation;tumor;tumorigenesis;Variant;virtual;Wit;Work;ZIP protein

PROJECT_TITLE: c-Myc Function


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;Anatomy;Anti-Retroviral Agents;antiretroviral therapy;Autopsy;BACH2 gene;Biological Assay;Blood;Bone Marrow Transplantation;Brain;CCR;CD4 Positive T Lymphocytes;Cd68;CD8B1 gene;Cell Line;Cells;Chimerism;Chronic;clinical center;Clinical Protocols;Clonal Expansion;cohort;Collaborations;Colon;Colonoscopy;Complement;Containment;Data;Development;driving force;Evaluation;Event;Evolution;follow-up;Funding;Future;Gammaretrovirus;Gastrointestinal tract structure;Gene Expression;Genes;Genetic;Goals;Grant;HIV;HIV Drug Resistance Program;HIV-1;homologous recombination;ileum;Immune;Immunohistochemistry;In Vitro;in vivo;Individual;Infection;innovation;insight;integration site;Interruption;Investigation;jejunum;Learning;Long-Term Effects;Lung;Lymphocyte;Lymphoid Tissue;Methodology;Methods;Molecular Virology;National Institute of Allergy and Infectious Disease;National Institute of Neurological Disorders and Stroke;next generation sequencing;novel strategies;Pathology;Pathway interactions;Patients;Penetration;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Plasma;Population;post-transplant;programs;Proliferating;Protocols documentation;Provirus Integration;Proviruses;Pseudoautosomal Region;Reporting;repository;Research Personnel;Sampling;Sampling Studies;Shapes;Site;Sorting;Source;STAT5B gene;Structure;T-Cell Receptor;T-Lymphocyte;Technology;Therapeutic;Tissues;tool;Transplantation;United States National Institutes of Health;Universities;Viral;Viremia;Virus;virus host interaction;Work;X Chromosome

PROJECT_TITLE: HIV Persistence During Suppressive Antiretroviral Therapy


NIH_SPENDING_CATS: Cancer;Complementary and Integrative Health;HIV/AIDS;Natural Products

PI_NAMEs: BEUTLER, JOHN  (contact)

PROJECT_TERMS: Actinobacteria class;Agreement;analog;Biological Assay;bioweapon;Boston;Cells;Chemicals;Collaborations;Collection;computerized data processing;Data;design;Development;Funding;gang;Goals;improved;Industrialization;Information Systems;International;Kansas;Kazakhstan;Laboratories;Libraries;material transfer agreement;Methodology;Microbiology;Molecular Target;National Institute of General Medical Sciences;Natural Products;Online Systems;Pharmaceutical Chemistry;Plant Extracts;Plant natural product;Plants;Process;programs;Proteins;repository;Research Personnel;Sampling;Scanning;Science;Scientist;screening;screening program;Series;Soil;Source;Specimen;Structure;System;Technology;Testing;Traditional Medicine;Travel;Tube;Universities;US State;virology

PROJECT_TITLE: Building Libraries with Chemical Diversity for Screening


NIH_SPENDING_CATS: Bioengineering;Brain Cancer;Brain Disorders;Cancer;Kidney Disease;Natural Products;Neurofibromatosis;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PROJECT_TERMS: Academia;Actins;addiction;Address;African;Algorithms;Allografting;analog;Animal Model;anti-cancer therapeutic;anticancer activity;Antineoplastic Agents;Benzene;Bioinformatics;Biological Assay;Biological Testing;Breast Cancer cell line;Cancer Cell Growth;Cancer cell line;cell growth;Cell Line;Cells;Cellular Assay;cellular imaging;Central Nervous System;Central Nervous System Neoplasms;Child;Collaborations;Collection;Cytoskeleton;Data;Defect;Deoxyglucose;Dependence;Development;drug candidate;Dryness;Electronics;enantiomer;Esters;Euphorbiaceae;Ewings sarcoma;F-Actin;Formulation;Foundations;Fractionation;Glioblastoma;Glucose;Glycolates;Grant;HSF1;in vitro activity;in vivo Model;inhibitor;Investigation;Iowa;Isomerism;Libraries;Link;Location;Macaranga;Malignant Neoplasms;methyl group;Miniature Swine;Modeling;Molecular Target;Natural Compound;Natural Products;Natural Source;Nature;Neurofibromatosis 1;novel;Optical Rotation;oxysterol binding protein;Pathway interactions;Pattern Recognition;Peripheral Nerve Sheath Neoplasm;Pharmacologic Substance;Pharmacotherapy;Phyllanthus;pi bond;Plants;Play;preclinical development;Province;Renal Carcinoma;Renal Cell Carcinoma;renal toxin;Reporting;Role;Sampling;schweinfurthin A;Sesquiterpenes;Small Interfering RNA;Source;Starvation;stem;Sterols;Structure;Synthesis Chemistry;Tanzania;Testing;Toxic effect;Trees;tumor;Tumor Cell Line;Universities;Variant;Xenograft Model

PROJECT_TITLE: Development of Natural Product Leads as Anticancer Therapeutics


NIH_SPENDING_CATS: Cancer;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Natural Products

PI_NAMEs: OKEEFE, BARRY  (contact)

PROJECT_TERMS: 2019-nCoV;assay development;Biochemical;Biological Assay;Cells;Crystallization;Enzymes;inhibitor;interest;Libraries;Malignant Neoplasms;Modification;Molecular Biology;nanomolar;Natural Products;Paper;Phosphotransferases;Process;Productivity;Protein Chemistry;protein protein interaction;Publishing;receptor binding;Role;Sampling;Scanning;screening;Technology

PROJECT_TITLE: Cell-free assay technologies for the identification of active compounds


NIH_SPENDING_CATS: Cancer;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Natural Products;Prevention

PROJECT_TERMS: 2019-nCoV;Amino Acid Sequence;analog;Animals;anti-cancer;Antibodies;anticancer activity;aqueous;Biological;Biological Response Modifier Therapy;Clinical;clinical development;Communities;Cyanovirin-N;Evaluation;Extramural Activities;Goals;Homologous Protein;Human;Lectin;Legal patent;Libraries;Ligands;marine;member;Methods;Molecular Biology;Molecular Target;Natural Products;Natural Source;novel;oxidation;peptide natural products;Peptides;Phase I Clinical Trials;Protein Chemistry;Proteins;Publications;Reagent;Research;Research Project Grants;Resistance;Resources;Source;three dimensional structure;Viral Cancer;Work

PROJECT_TITLE: Isolation of bioactive proteins from natural product extracts


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

PI_NAMEs: MITSUYA, HIROAKI  (contact)

PROJECT_TERMS: Amino Acid Sequence;Amino Acid Substitution;analog;anti-hepatitis B;Anti-viral Agents;Anti-viral Therapy;attenuation;Binding;Binding Sites;Cell-Free System;Cells;cellular imaging;Characteristics;Chemicals;Circular DNA;Cirrhosis;clinical application;Combined Modality Therapy;Compensation;Complex;Cryoelectron Microscopy;Cyclopentenes;Data;deoxyguanosine triphosphate;design;Detection;Detergents;Development;DNA;DNA Primers;Drug resistance;drug resistant virus;entecavir;Escherichia coli;Evaluation;flexibility;Fluorescein-5-isothiocyanate;Genes;Hepatitis B Surface Antigens;Hepatitis B Vaccination;Hepatitis B Virus;Hepatocyte;HIV resistance;HIV-1;Human;Hydrophobicity;Immune;improved;In Vitro;in vivo;Incidence;inhibitor;Integration Host Factors;Interferons;Investigational Therapies;Knowledge;Label;Length;Life;Liver;Liver Cirrhosis;Liver diseases;Measures;Mitochondria;Modification;Molecular;Molecular Chaperones;Mus;mutant;novel;Nucleocapsid;Nucleosides;Nucleosome Core Particle;Oral;Patients;Phase;Phenotype;Play;pol genes;Positioning Attribute;Predisposition;prevent;Primary carcinoma of the liver cells;Prognosis;Property;Proteins;Public Health;Radioisotopes;Reading Frames;Recombinants;Reporting;resistance mutation;Reverse Transcriptase Inhibitors;Ribonuclease H;RNA;Roentgen Rays;Role;Safety;senescence;Site;Solubility;Structure;Surface Antigens;Tertiary Protein Structure;Therapeutic;Toxic effect;tripolyphosphate;Viral;Viral Genome;Virus Diseases;Withholding Treatment;X-Ray Crystallography

PROJECT_TITLE: Development of Novel Agents Active against Hepatitis B Virus


PI_NAMEs: MEIER, JORDAN LESLIE (contact)

PROJECT_TERMS: Acceleration;Acetyl Coenzyme A;Acetylation;Acetyltransferase;Address;Amino Acids;Archaeal RNA;Area;Benchmarking;Binding;Biochemical;Biological;Biological Assay;Biological Products;biological systems;Biology;Cancer Biology;Cancer Control;cancer diagnosis;cancer therapy;Cells;Cellular Stress;cellular targeting;Chemicals;chemoproteomics;Clinical Trials;Coenzyme A;CREBBP gene;Cryoelectron Microscopy;Cytidine;Dependence;Deposition;design;Detection;Development;Drug Design;drug discovery;Drug resistance;enzyme activity;Enzymes;EP300 gene;Epigenetic Process;epigenetic regulation;epitranscriptomics;Exhibits;Fumarates;Future;Gene Expression Regulation;Genes;Genetic Transcription;Glean;Goals;Head;Hereditary Leiomyomatosis and Renal Cell Cancer;Hereditary Neoplastic Syndromes;histone acetyltransferase;Inborn Errors of Metabolism;Inherited;inhibitor;insight;Knockout Mice;Malignant Neoplasms;Mediating;Messenger RNA;Metabolic;metabolic abnormality assessment;Metabolism;metabolomics;Methods;Modeling;Modification;Molecular;Monitor;mouse model;Neoplasm Metastasis;new technology;novel;novel strategies;Nucleic Acids;Oncogenic;Oncology;Organism;Pathway interactions;Pharmaceutical Preparations;Pharmacologic Substance;Phosphotransferases;Positioning Attribute;Post-Translational Protein Processing;Predisposition;Proteins;Reaction;Regulation;Reporting;Ribosomes;RNA;Role;Signal Pathway;Signal Transduction;small molecule;small molecule inhibitor;Specific qualifier value;Specificity;Stress;Structure;Technology;Technology Development Study;Therapeutic;Toxic effect;Transfer RNA;Translations;tumor;tumor metabolism;tumorigenic;United States National Institutes of Health;unpublished works;urea cycle;Work

PROJECT_TITLE: Chemical Biology Platforms to Define the Metabolism-Epigenetics Interface


NIH_SPENDING_CATS: Cancer;Hematology

PI_NAMEs: WALTERS, KYLIE  (contact)

PROJECT_TERMS: anticancer activity;Apoptosis;Binding;Cells;Chemicals;Exhibits;Glues;Goals;Hematologic Neoplasms;inhibitor;multicatalytic endopeptidase complex;Multiple Myeloma;Mus;novel strategies;Process;Proteasome Binding;protein degradation;protein expression;Proteins;receptor;recruit;Signaling Protein;Site-Directed Mutagenesis;skills;small molecule;Structure;Surface;tumor growth;UBE3A gene;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;Xenograft Model

PROJECT_TITLE: Ubiquitin signaling for protein degradation


NIH_SPENDING_CATS: Cancer;Genetics

PI_NAMEs: KELLY, ALEXANDER  (contact)

PROJECT_TERMS: Affect;Aneuploidy;Antineoplastic Agents;aurora B kinase;Binding;borealin;cancer cell;Cell Culture Techniques;Centromere;Chemicals;Chromatin;chromatin modification;Chromosome Condensation;Chromosome Segregation;Chromosome Structures;Chromosomes;Collaborations;Complex;condensin;Cytokinesis;Defect;DNA;Drug Targeting;egg;Embryo;embryo cell;Ensure;Enzymes;Eukaryota;Event;Evolution;Future;Genome;Genomic Instability;helicase;Hi-C;Histones;Human;inner centromere protein;insight;interdisciplinary approach;interest;Kinetics;Kinetochores;Light;Maintenance;Mammals;Mediating;Meiosis;Microtubules;Mitosis;Mitotic;Molecular;Neoplasm Metastasis;Oocytes;Physical condensation;Play;Post-Translational Protein Processing;Process;Proteins;Regulation;Research;Rod;Role;segregation;Signal Transduction;Sister Chromatid;Site;Somatic Cell;Structure;survivin;Therapeutic Intervention;transcription factor TFIIH;Transcription Initiation;translocase;tumor;vertebrate embryos;Vertebrates;Work;Xenopus

PROJECT_TITLE: Role of kinetochore proteins in chromosome segregation


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Esophageal Cancer;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Infectious Diseases;Lung;Lung Cancer;Microbiome;Precision Medicine;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

PI_NAMEs: HARRIS, CURTIS  (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acceleration;Acids;Adenocarcinoma;Annual Reports;anti-cancer research;Anti-Inflammatory Agents;Antigen Presentation Pathway;Anus;bench to bedside;Bioinformatics;Biological Assay;Biological Factors;Biological Markers;Blood Platelets;Campylobacter;cancer biomarkers;cancer cell;cancer diagnosis;Cancer Patient;Cancer Prognosis;cancer risk;cancer therapy;carcinogenesis;Case/Control Studies;CD4 Positive T Lymphocytes;Cells;Cholestanes;Clinical;cohort;Collaborations;Colorectal Cancer;computational pipelines;computed tomography screening;Contracts;Creatine;cytokine;Data;Data Set;Detection;Development;Diagnosis;Diagnostic;diagnostic value;Disease;Disease Progression;DNA Methylation;dysbiosis;Early Diagnosis;Environmental Exposure;Esophageal carcinoma;Esophagus;Evaluation;Exposure to;Fusobacterium;Glucuronides;Goals;gut microbiome;health disparity;Healthcare;high risk;high risk population;Human;Hydrocortisone;IL8 gene;immune cell infiltrate;Immunotherapy;improved;In Vitro;Individual;individual patient;Infection;Infiltration;Inflammation;Inflammatory;interleukin-23;Intervention;Investigation;KRAS2 gene;Laboratories;Lactobacillus;Large Intestine Carcinoma;Length;Leptotrichia;Life;liquid biopsy;Liquid Chromatography;low dose computed tomography;Lung;Lung Adenocarcinoma;lung cancer screening;lung carcinogenesis;Macrophage;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Medical;Messenger RNA;metabolome;Metagenomics;Microbe;microbial;microbiome;MicroRNAs;Mitochondria;Modality;Modeling;Molecular;Molecular Analysis;Molecular Carcinogenesis;Molecular Genetics;Monitor;mouse model;Mus;Mutation;Myeloid Cells;Neoplasm Metastasis;neoplastic cell;neutrophil;Neutrophil Infiltration;NF-kappa B;non-smoker;novel;Outcome;Pathway interactions;patient subsets;Patients;Phenotype;Plasma;Play;Population;population based;precision medicine;precision oncology;prevent;Prevention;Prevotella;Prognosis;prognostic;prognostic value;programs;Proteome;Publications;Publishing;recruit;Recurrence;Reporting;Research;Residencies;resident commensals;Resources;response;riboside;Risk;Role;Sampling;Science;screening;screening program;Serum;Signal Transduction;single-cell RNA sequencing;Statistical Data Interpretation;Streptococcus;Sulfate;tandem mass spectrometry;targeted treatment;Taxonomy;Testing;The Cancer Genome Atlas;Therapeutic;therapeutic target;therapy outcome;Tissue Sample;Tissues;TLR4 gene;tool;TP53 gene;transcriptome sequencing;tumor;tumor growth;tumor microenvironment;Tumor Promotion;Tumor Tissue;tumorigenesis;tumorigenic;urea cycle;urinary;Urine;validation studies;Veillonella;Work

PROJECT_TITLE: Precision Medicine of Cancer


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Immunotherapy;Lung;Lung Cancer;Nanotechnology;Neurosciences;Orphan Drug;Physical Injury - Accidents and Adverse Effects;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

PROJECT_TERMS: Adverse effects;Aging;Alzheimer's disease model;Antibodies;Aorta;Apoptosis;Area;Astrocytes;Biological Assay;Brain;cancer cell;CAR T cell therapy;CD8-Positive T-Lymphocytes;Cell Aging;Cell Death;Cell Surface Proteins;Cells;chimeric antigen receptor T cells;Chronic Lymphocytic Leukemia;chronic traumatic encephalopathy;Clinical;clinical application;Clinical Trials;Coculture Techniques;Collaborations;Cranial Irradiation;Crossbreeding;Data;Development;DNA Repair;drug candidate;drug repurposing;Drug Screening;Encapsulated;Enterobacteria phage P1 Cre recombinase;Expression Profiling;Fibroblasts;Future;Generations;Genetic Transcription;Genome Stability;Glioblastoma;Goals;Heart;high throughput screening;Human;IL13RA1 gene;Impaired cognition;Impairment;improved;In Vitro;in vivo;in vivo Model;inducible gene expression;Injections;Invaded;knock-down;Knock-in Mouse;Knockout Mice;Leukemic Cell;lipid nanoparticle;liver injury;lung cancer cell;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Metabolic;metabolome;migration;Modeling;Modification;Molecular;mouse model;Mouse Strains;Mus;mutant;Mutation;Natural Products;Nerve Degeneration;Neurodegenerative Disorders;non-oncogenic;Normal Cell;novel;nutrition;Oncogenic;Organ;Pathology;Pathway interactions;Patients;Pennsylvania;Pharmaceutical Preparations;Phenotype;Primates;Progeria;Proliferating;Property;Protein Isoforms;Proteins;Proteome;Protocols documentation;Publications;Radiation therapy;Refractory;Research;RNA Splicing;ROR1 gene;senescence;senescence associated secretory phenotype;Signal Transduction;Site;Skin;Small Interfering RNA;small molecule libraries;Solid Neoplasm;Syndrome;Tamoxifen;Testing;Therapeutic;Therapeutic Effect;Tissues;TP53 gene;Trademark;Transgenic Mice;Translating;Traumatic Brain Injury;tumor;tumor microenvironment;Tumor Suppression;tumorigenesis;Universities;Xenograft procedure

PROJECT_TITLE: p53, Aging, and Cancer


PI_NAMEs: MILI, STAVROULA  (contact)

PROJECT_TERMS: 3' Untranslated Regions;Antisense Oligonucleotides;Area;cancer cell;cancer type;cell motility;combat;Complex;Data;Disease;Disease Progression;Goals;Mammalian Cell;Messenger RNA;migration;Molecular Motors;Motor;Neoplasm Metastasis;novel;Pathway interactions;Proteins;recruit;Regulation;RNA;RNA-Binding Proteins;therapeutic target;trafficking;Work

PROJECT_TITLE: Regulation and functional effects of localized RNAs


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;HIV/AIDS;Human Genome;Immunization;Nanotechnology;Prevention;Prostate Cancer;Urologic Diseases;Vaccine Related;Vaccine Related - AIDS;Women's Health Research

PI_NAMEs: JONES, JENNIFER  (contact)

PROJECT_TERMS: 4T1;biophysical properties;CCR;Colon;Computer software;CT26;Detection;DNA Transposable Elements;Elements;Endogenous Retroviruses;exosome;HCT116 Cells;Human;Immune Evasion;Immune response;Kidney;Knowledge acquisition;Malignant lymphoid neoplasm;Malignant Neoplasms;Mammary Neoplasms;MC38;Methods;microvesicles;Modeling;Mouse Mammary Tumor Virus;Mus;nano;nanoparticle;Neoplasm Metastasis;novel;particle;Patients;PC3 cell line;Phenotype;phenotypic biomarker;Plasma;PPBP gene;pre-clinical;programs;Prostate;Protocols documentation;Publications;Reporting;Research;Resolution;RNA;Sampling;Serum;Site Visit;submicron;Surface;Testing;transcriptome sequencing;treatment response;tumor;Tumor Biology;Tumor Cell Line;Tumor-Derived;United States National Institutes of Health;Viral;Work

PROJECT_TITLE: Biophysical Characterization of EVPs and other Macromolecular Nanoparticles


NIH_SPENDING_CATS: Cancer;Radiation Oncology

PROJECT_TERMS: 4T1;Blood Vessels;CCR;Cells;Cephalic;Cessation of life;Clinical;clinical practice;Clinical Protocols;clinical translation;Collaborations;curative treatments;Data;design;Disease;Disseminated Malignant Neoplasm;Elements;extracellular vesicles;Goals;Immune;immune activation;Immune response;immunoregulation;Immunosuppression;improved;improved outcome;irradiation;Laboratory Research;liquid biopsy;Malignant Neoplasms;Medical Oncology;Modeling;Mus;nanobiology;Neoplasm Metastasis;neoplastic cell;particle;Patient Care;Patient Monitoring;patient population;Patients;Performance;phosphatidylserine receptor;preclinical study;Process;Protocols documentation;Quality of life;Radiation;Radiation Oncology;Radiation therapy;Research;response to injury;Role;Sampling;Stromal Cells;Stromal Neoplasm;Study Section;Surgical Oncology;System;tissue injury;tool;translational goal;Translational Research;treatment response;tumor;Tumor Markers;tumor progression;United States National Institutes of Health;Unresectable;Work

PROJECT_TITLE: Discovery of Tumor, Treatment Response, and Systems-based EVP Signatures


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Women's Health Research

PI_NAMEs: HUANG, JING  (contact)

PROJECT_TERMS: Affinity;anti-cancer research;Autophagocytosis;Biological Markers;Biological Sciences;Breast Cancer Cell;breast cancer metastasis;CBFB gene;Cell Surface Proteins;Cells;Chromatin;Gene Expression Regulation;Genetic Transcription;Goals;Immune Evasion;Immunocompetent;Immunologic Surveillance;inhibition of autophagy;inhibitor;Malignant Breast Neoplasm;Metastatic Neoplasm to the Lung;Molecular;mutant;Mutation;nanobodies;novel therapeutic intervention;Osteosarcoma;Play;preclinical study;Publishing;Role;Runx2 protein;Testing;TP53 gene;transcription factor;Translating;tumor growth;Work

PROJECT_TITLE: Vulnerabilities in osteosarcoma and breast cancer


PI_NAMEs: SCHNERMANN, MARTIN  (contact)

PROJECT_TERMS: Aniline;Antibodies;Benzoxazoles;bile duct;Biodistribution;Biological;biomedical imaging;Cells;Chemical Structure;Chemistry;chromophore;Complex;cyanine;Cyclization;design;Development;Development Polarity;Exhibits;experience;Fluorescence;fluorescence-guided surgery;fluorophore;functional group;Image;Image-Guided Surgery;Improve Access;improved;in vivo;in vivo optical imaging;insight;Label;Liver;Malignant Neoplasms;Methods;Microscopy;Modification;Molecular;molecular imaging;nanoparticle;New Agents;novel;novel strategies;optical imaging;Optics;Organic Synthesis;Penetration;Permeability;Pharmaceutical Chemistry;Preparation;Property;Reaction;Reagent;Reporting;research clinical testing;scaffold;Signal Transduction;small molecule;Sodium Acetate;Solid Neoplasm;Subcellular structure;Techniques;Tissues;tumor;uptake;Variant

PROJECT_TITLE: New Synthetic Approaches to Small Molecules for Imaging


PI_NAMEs: KOBAYASHI, HISATAKA  (contact)

PROJECT_TERMS: Angiography;Antibodies;Binding;Biodistribution;Biological;cancer imaging;Cells;Clinical;clinical application;Contrast Media;design;Detection;Diagnostic;dimer;Disease;Electron Transport;flexibility;Fluorescence;fluorescence imaging;Fluorescence Resonance Energy Transfer;Gadolinium;Gamma-glutamyl transferase;Homo;imaging modality;imaging probe;in vivo;Indocyanine Green;Iodine;Label;Lesion;Magnetic Resonance Imaging;Malignant Neoplasms;Molecular;molecular imaging;Operative Surgical Procedures;Optics;pharmacologic;Photons;Procedures;Property;Published Comment;Radioisotopes;Radionuclide Imaging;rational design;Sensitivity and Specificity;Signal Transduction;Specificity;Testing;Tissues;X-Ray Computed Tomography

PROJECT_TITLE: Activatable molecular cancer imaging probe


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Digestive Diseases;Esophageal Cancer;Nanotechnology;Orphan Drug;Rare Diseases

PROJECT_TERMS: Antibodies;Appearance;Area;cancer cell;Cancer Center;cancer therapy;Cell Death;cell injury;cell killing;Cell membrane;Cell surface;cell type;Cells;chemotherapy;Clinical Trials;Collaborations;Development;Diagnosis;effective therapy;Epidermal Growth Factor Receptor;ERBB2 gene;esophageal squamous cell cancer;Exposure to;FOLH1 gene;Goals;GPC3 gene;Head and neck structure;hydrophilicity;IL2RA gene;Image;imaging modality;imaging probe;improved;Light;Liposomes;Malignant Neoplasms;manufacturing scale-up;Membrane;mesothelin;Mucin 1 protein;Names;nanoparticle;nanoparticle delivery;nanosized;Necrosis;non-invasive imaging;Normal Cell;novel;Penetration;photoimmunotherapy;Photosensitizing Agents;Process;Proteins;Reagent;Sensitivity and Specificity;Singapore;Site;Surgeon;targeted cancer therapy;Therapeutic Effect;Tissues;tumor

PROJECT_TITLE: Cancer-cell specific therapy: photo-immunotherapy


NIH_SPENDING_CATS: Cancer

PI_NAMEs: LEE, KYUNG  (contact)

PROJECT_TERMS: Aneuploidy;Architecture;Biochemical Process;Biological Process;Cell Cycle;Cell Physiology;Cells;Centrioles;Centrosome;Chromosome Segregation;Client;Complex;Copying Processes;Defect;Development;Ensure;Eukaryotic Cell;Event;genome integrity;Goals;Human;human disease;Imaging technology;interdisciplinary approach;Life;macromolecular assembly;Malignant Neoplasms;Mediating;Mitotic spindle;Modeling;Molecular;Molecular Weight;mutant;novel;Organism;Pericentriolar Regions;Play;PLK1 gene;Procentriole;Process;Protein Dynamics;Proteins;Research;Role;scaffold;self organization;Shapes;single molecule;Site;Structure;Subcellular structure;Work

PROJECT_TITLE: Molecular basis of centriole duplication


PI_NAMEs: TANNER, KANDICE  (contact)

PROJECT_TERMS: acquired factor;Allografting;Antigen Presentation;Architecture;Atypia;B-Lymphocytes;Bacteria;Bacterial Infections;Basement membrane;Benign;Biological Models;biophysical properties;cancer cell;cell motility;cell type;Cellular Morphology;chemical property;Chemicals;Clinical;Complex;Dermis;Disease;Dysplastic Nevus;Epidermis;Evolution;Extracellular Matrix;Fibroblasts;Glycolysis;Histologic;Human;human model;Immune;immune activation;immune cell infiltrate;Immune system;In Vitro;in vivo;in vivo Model;Individual;Invaded;keratinocyte;Lesion;Macrophage;Major Histocompatibility Complex;Measures;mechanical properties;Mechanics;melanocyte;Melanoma;Metabolic;Metastatic Melanoma;Modeling;morphogens;Mus;Natural Killer Cells;Nevus;Organ;Organ Model;Outcome;Oxidative Phosphorylation;Penetration;Precancerous Melanosis;Primary Neoplasm;Radial;Radial Growth Phase;Regulation;sensor;Signal Pathway;Signal Transduction;Skin tumorigenesis;Subcutaneous Tissue;T-Lymphocyte;Testing;three dimensional cell culture;three-dimensional modeling;Tissues;tumor;tumor metabolism;Tumor Suppressor Proteins;Vertebrates;Vertical Growth Phase;Virus;Work;Xenograft procedure;Zebrafish

PROJECT_TITLE: Mechanical regulation of the microenvironmental niche in skin tumorigenesis


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Genetics;Immunotherapy;Orphan Drug;Ovarian Cancer;Precision Medicine;Rare Diseases;Uterine Cancer;Women's Health Research

PI_NAMEs: LEE, JUNG-MIN  (contact)

PROJECT_TERMS: Accent;AKT1 gene;anti-PD-L1;Antibody-drug conjugates;arm;bench to bedside;bevacizumab;Binding;Biological Markers;Biology;Biopsy;Biopsy Specimen;Blood;Blood specimen;Canada;Cancer cell line;Cancer Model;Cancer Patient;Cause of Death;CCR;Cell Cycle;Cell Cycle Arrest;Cell Cycle Checkpoint;Cell Death;cell growth;Cell Proliferation;Cessation of life;Characteristics;CHEK1 gene;chemokine;chemotherapy;Clinic;Clinical;clinical development;Clinical Research;clinical trial protocol;Clinical Trials;Collaborations;Collection;Combined Modality Therapy;Complement;Core Facility;Correlative Study;cytokine;cytotoxicity;Data;design;Development;Disease;DNA Damage;DNA Repair;DNA sequencing;Drug Combinations;Drug resistance;Drug Targeting;effective therapy;Effectiveness;Endometrial Carcinoma;Endothelium;Enrollment;exceptional responders;Gene Expression;Gene Mutation;genome integrity;Genomic Instability;Goals;Gynecologic Oncology Group;helicase;high risk;homologous recombination;Immune;immune checkpoint blockade;improved;In Vitro;in vivo;inhibitor;insight;Interferons;Interruption;Intramural Research Program;Investigation;investigator-initiated trial;Japan;KDR gene;Korea;Laboratories;M cell;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Manuscripts;Mediating;Mediator;Membrane Glycoproteins;Modeling;Molecular;Molecular Profiling;mRNA Expression;Mutation;Mutation Analysis;National Center for Advancing Translational Sciences;NCI Center for Cancer Research;new therapeutic target;next generation;novel;novel drug combination;novel therapeutics;Oncology;Operative Surgical Procedures;Outcome;Ovarian Carcinoma;Pathway interactions;Patient observation;Patients;Phase;phase 2 study;phase II trial;Phosphotransferases;Physicians;PI3K/AKT;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;Pre-Clinical Model;pre-clinical research;preclinical study;predictive marker;primary endpoint;programmed cell death ligand 1;programs;prospective;Proteins;Proto-Oncogene Proteins c-akt;recombinational repair;recruit;Recurrence;replication stress;Research;Research Personnel;Resistance;Resolution;response;response biomarker;Science;Scientist;Serous;Signal Transduction;Site;standard of care;stem;Subgroup;TACSTD2 gene;Testing;Therapeutic;therapeutic target;Tissue Sample;TP53 gene;transcriptome sequencing;translational approach;Translational Research;translational research program;translational scientist;translational study;tumor;Tumor Debulking;Tyrosine Kinase Inhibitor;United States;United States National Institutes of Health;Up-Regulation;Woman;Women's study;women's treatment;Work

PROJECT_TITLE: Leveraging DNA damage repair pathways as therapeutic targets in womens cancers


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Prostate Cancer;Radiation Oncology;Urologic Diseases

PI_NAMEs: CITRIN, DEBORAH  (contact)

PROJECT_TERMS: Aftercare;androgen deprivation therapy;Biochemical;Biological;Biological Markers;biomarker identification;Biopsy;Blood;Cancer Patient;Cancer Therapy Evaluation Program;candidate selection;Characteristics;chemoradiation;chemotherapy;Chemotherapy and/or radiation;Clinical;clinical translation;Clinical Trials;Data;Data Set;Development;effective therapy;Evolution;Failure;Gene Expression Profile;Genetic;genetic signature;Goals;human tissue;imaging modality;In Vitro;in vivo;inhibitor;irradiation;Knowledge;Laboratories;Laboratory Study;Local Therapy;Localized Malignant Neoplasm;Longterm Follow-up;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;MEK inhibition;MEKs;men;Molecular;Neoadjuvant Therapy;novel;Operative Surgical Procedures;Outcome;participant enrollment;Pathway interactions;patient population;Patients;Phase I Clinical Trials;phase I trial;prognostic;programs;prospective;Prostate;Prostate Cancer therapy;Protocols documentation;Publishing;Radiation;radiation resistance;radiation response;Radiation therapy;Radiation-Sensitizing Agents;Radiobiology;radiological imaging;Radiosensitization;Rectal Cancer;Recurrence;Recurrent disease;Recurrent tumor;Research;Resistance;resistance factors;Risk Factors;Sampling;targeted radiotherapeutic;Therapeutic;Time;Tissues;Transforming Growth Factor beta;treatment strategy;tumor;tumor specificity;Tumor Tissue;Work

PROJECT_TITLE: Targeting mechanisms of radiation resistance


NIH_SPENDING_CATS: Bioengineering;Cancer

PROJECT_TERMS: Adherence;Animals;Architecture;Biological;Biophysical Process;Biophysics;Blood capillaries;Bone Marrow;Brain;Breast Cancer Cell;Cancer Patient;Cardiovascular system;cell behavior;Cell-Cell Adhesion;Cell-Matrix Junction;Cells;Cellular Morphology;Chemicals;Cues;Disseminated Malignant Neoplasm;Distant;Embryo;Environment;environmental change;Extravasation;Fishes;Genetic;Home;Human;human model;in vivo;Infiltration;Integrins;intravital imaging;intravital microscopy;Knowledge;Lesion;Malignant Neoplasms;Maps;Mechanics;Microbial Biofilms;mortality;mouse model;multimodality;Mus;Neoplasm Metastasis;neoplastic cell;Organ;Patients;personalized predictions;Phase;Phenotype;physical property;pressure;Proliferating;refractory cancer;Regulation;Resistance;Resolution;Role;Signal Transduction;Site;Soil;three dimensional cell culture;tissue mapping;tissue tropism;Tissues;trait;Transcriptional Regulation;tumor;tumor progression;viscoelasticity;Visualization;Zebrafish

PROJECT_TITLE: The role of the tumor biofilm in determining tissue tropism


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer

PROJECT_TERMS: Address;Animal Model;Antibodies;Binding;CCR;Charge;Chemicals;Chemistry;Clinical;Collaborations;cyanine;design;Development;Drug Delivery Systems;fluorophore;Goals;Hydrophobicity;Image;imaging probe;improved;in vivo;insight;Label;Ligands;Light;Monoclonal Antibodies;new therapeutic target;optical imaging;Optics;Pharmaceutical Preparations;physical property;Play;Property;Role;Series;Site;small molecule;Structure;Testing;therapeutic development;Toxic effect;tumor;tumor microenvironment;uptake;Variant;Work

PROJECT_TITLE: Applying Optical Approaches to the Drug Delivery Problem


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

PI_NAMEs: GU, SHUO  (contact)

PROJECT_TERMS: Address;Area;Biochemical;Biogenesis;Bioinformatics;Biological;Biological Assay;Biological Process;Cancer Biology;cancer therapy;cancer type;Cells;deep sequencing;design;Development;DICER1 gene;Disease;DNA Sequence Alteration;Encyclopedias;Focus Groups;Gene Expression;Genes;Genetic;Genetic study;Glioblastoma;Goals;Health;Human;human disease;improved;in vivo;insight;interdisciplinary approach;Malignant Neoplasms;Mammals;MicroRNAs;Modification;next generation sequencing;novel;Pathway interactions;Play;Production;programs;Protein Isoforms;Proteins;Regulation;Regulator Genes;Research;Resources;RNA-Binding Proteins;Role;Safety;small hairpin RNA;Syndrome;Therapeutic;therapeutic miRNA;therapeutic target;tool;Translating;tumor;tumorigenesis;Untranslated RNA;uridylate;Work

PROJECT_TITLE: Mechanism, Regulation and Application of miRNA pathway in cancer


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Complementary and Integrative Health;Digestive Diseases;Infectious Diseases;Liver Cancer;Liver Disease;Natural Products;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Skin Cancer

PI_NAMEs: DU, LIN  (contact)

PROJECT_TERMS: Advanced Development;Age Years;alternative treatment;analog;anti-cancer;assay development;bioactive natural products;Biochemical;Biochemistry;Biological;Biological Assay;Biology;Cancer Biology;cancer cell;cancer type;CCR;Cell Line;Cell Physiology;Cellular biology;Characteristics;Chemicals;Chemistry;Chimeric Proteins;Collaborations;Collection;Complement;Computational Science;Computer Models;coping;cytotoxic;cytotoxicity;Data Analyses;Datura;design;Development;Digit structure;diketopiperazine;Disease;DNA;DNA Topoisomerases;Enzyme-Linked Immunosorbent Assay;Evaluation;Exhibits;experience;Extramural Activities;Fibrolamellar Hepatocellular Carcinoma;Fingerprint;Fractionation;Gene Fusion;Generations;Genes;Genetic;Goals;HCT116 Cells;high throughput screening;HIV;Immune checkpoint inhibitor;Immunology;improved;Individual;Industrialization;Inositol;insight;interdisciplinary approach;Journals;kinase inhibitor;Large Intestine Carcinoma;Legal patent;Libraries;Link;Malignant neoplasm of liver;Malignant Neoplasms;Manuscripts;marine organism;Merkel cell carcinoma;Mesothelioma;Methodology;Microbe;Modification;Molecular;Molecular Biology;Molecular Probes;Molecular Target;nanomolar;Natural product discovery;Natural Products;Natural Products Chemistry;Natural Source;Neurosecretory Systems;New Agents;novel therapeutics;Oncogenic;Organic Synthesis;Paper;Pathway interactions;patient population;Patients;pembrolizumab;Penicillium;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phosphotransferases;Plants;Play;Positioning Attribute;preclinical development;Preparation;PRKCA gene;Process;programs;Proliferating;Protein Chemistry;Protein-Serine-Threonine Kinases;Publications;Reporting;Research;Resources;response;RNA;RNA Virus Infections;Role;scaffold;Scientist;screening;secondary metabolite;Secure;Serine;Sesquiterpenes;Skeleton;skills;Skin Cancer;Source;Specificity;structural biology;Structure;Survival Rate;Synthesis Chemistry;Techniques;Technology;therapeutic development;Topoisomerase;translational potential;tumor;tumorigenesis;United States National Institutes of Health

PROJECT_TITLE: Natural Products Discovery and Characterization Through Network Collaborations


PI_NAMEs: SCHNEEKLOTH, JOHN  (contact)

PROJECT_TERMS: Amino Acid Sequence;Binding;Biological Process;biological systems;cancer initiation;Cells;Code;Communicable Diseases;DNA;DNA Structure;Drug Targeting;drug-like compound;Elements;G-Quartets;Genetic Transcription;Genome;Goals;Human;Human Genome;interest;Label;Laboratories;Libraries;Malignant Neoplasms;Molecular;molecular recognition;new technology;novel;Nucleic Acid Binding;Nucleic Acid Folding;Nucleic Acids;Oligonucleotides;Pharmaceutical Preparations;Phenotype;Proteins;Publishing;RNA;small molecule;Structure;Technology;Transcript;transcriptome;tumor progression;Untranslated RNA;Work

PROJECT_TITLE: Identification of Nucleic Acid Binding Small Molecules


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Kidney Disease;Rare Diseases;Urologic Diseases

PI_NAMEs: APOLO, ANDREA  (contact)

PROJECT_TERMS: adaptive immunity;advanced disease;Adverse event;angiogenesis;Angiogenesis Inhibition;Angiogenesis Inhibitors;Anorexia;Avidity;bevacizumab;Binding;Bladder Adenocarcinoma;Blood;Body Weight decreased;Cancer cell line;Cancer Patient;Carboplatin;Carcinoid Tumor;CCR;CD8-Positive T-Lymphocytes;Cell surface;Cells;checkpoint inhibition;chemotherapy;Cisplatin;Clear cell renal cell carcinoma;Clinical;Clinical Treatment;cohort;Data;Data Pooling;Databases;Dehydration;Diarrhea;Dose;Dose Limiting;effector T cell;Endoglin;Endometrial Carcinoma;ENG gene;Enzymes;Equilibrium;Evaluable Disease;exhaust;Fatigue;Flow Cytometry;Functional disorder;gemcitabine;Goals;granulocyte;HGF gene;Human;Immune;Immune checkpoint inhibitor;immunoregulation;Immunotherapeutic agent;improved;Innate Immune Response;International;ipilimumab;Journals;KDR gene;kidney cell;lenalidomide;Literature;Liver;Malignant neoplasm of penis;Malignant neoplasm of urinary bladder;Manuscripts;MAP Kinase Gene;Mediating;Medicine;Melanoma;Metastatic Renal Cell Cancer;Monoclonal Antibodies;monocyte;Mononuclear;mortality risk;Mucositis;Myelogenous;Myeloid-derived suppressor cells;Nausea;neoplastic cell;neuroendocrine differentiation;Neuroendocrine Tumors;New England;Nivolumab;Non-Small-Cell Lung Carcinoma;Pathway interactions;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;Phase;phase 1 study;phase 2 study;phase 3 study;Phase II Clinical Trials;phase III trial;PIK3CG gene;Placebos;Platinum;Population;Primary carcinoma of the liver cells;programmed cell death protein 1;Progressive Disease;Property;Protein Tyrosine Kinase;Proteins;Randomized;rare cancer;Receptor Protein-Tyrosine Kinases;Recommendation;Recurrence;Regulatory T-Lymphocyte;Renal Cell Carcinoma;Reporting;response;Risk;Running;Safety;safety assessment;Sarcomatoid Features;Sarcomatoid Renal Cell Carcinoma;Series;Signal Pathway;Signal Transduction;small molecule inhibitor;Squamous cell carcinoma;standard care;symposium;T-Lymphocyte;targeted agent;Testing;Therapeutic;Therapeutic Trials;Thyroid Gland;Toxic effect;Transitional Cell Carcinoma;treatment response;triple-negative invasive breast carcinoma;Triplet Multiple Birth;tumor;tumor growth;tumor microenvironment;tumor progression;Unresectable;Urine;Urothelium;Uterine Corpus Carcinosarcoma;Vomiting

PROJECT_TITLE: Targeting the MET Pathway in Urothelial Carcinoma


PROJECT_TERMS: anti-cancer;Antigens;Binding;biophysical techniques;biophysical tools;Cancer Biology;CD19 gene;CD22 gene;CD28 gene;chimeric antigen receptor;chimeric antigen receptor T cells;Complex;Cryo-electron tomography;cytotoxicity;Disease;Elements;Extracellular Space;FDA approved;G-Quartets;Geometry;Goals;Immunotherapy;leukemia/lymphoma;Leukemic Cell;Link;Malignant Neoplasms;Modeling;MYC gene;myosin VI;neoplastic cell;new therapeutic target;novel;Property;Signal Transduction;small molecule;structural biology;Structure;System;Transmembrane Domain;Ubiquitin

PROJECT_TITLE: Mechanisms of function and targeting for complexes relevant to cancer biology


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Rare Diseases;Regenerative Medicine

PI_NAMEs: BHANDOOLA, AVINASH  (contact)

PROJECT_TERMS: age related;Bone Marrow;Cell Lineage;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Defect;Development;Drug Targeting;epigenomics;Epithelial Cells;fetal;Gene Expression Profiling;Genetic Transcription;Growth;Hematopoietic;Immune;insight;interest;Laboratories;Lymphocyte;Lymphoid Cell;Maintenance;Modeling;Molecular;mouse model;Multiple Myeloma;Mutagenesis;Natural regeneration;notch protein;Organ;Osteoblasts;Plasma Cells;progenitor;programs;Purinoceptor;Role;Signal Transduction;single-cell RNA sequencing;System;T cell response;T-Cell Development;T-Lymphocyte;Technology;Thymic epithelial cell;thymic regeneration;Thymus Gland;Tissues;transcription factor;Work

PROJECT_TITLE: T cell Development and Regeneration


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: GILBERT, MARK  (contact)

PROJECT_TERMS: Adult Glioma;Astrocytes;Bioinformatics;Biological Models;Biology;Brain Neoplasms;Cancer cell line;Cell Culture Techniques;Cell Line;Cells;Cellular biology;Characteristics;Ciliary Neurotrophic Factor;Clinic;Clinical;Collaborations;Computer Analysis;Cytostatics;Data;Database Management Systems;Diffuse intrinsic pontine glioma;DNA methylation profiling;Embryo;Equilibrium;exome sequencing;experimental study;Gene Expression;Gene Expression Profiling;gene function;Genes;Genetic;genetic manipulation;genome-wide;Genomics;Genotype;Glioblastoma;Glioma;glioma cell line;Homeostasis;Human;immunoreaction;improved;In Vitro;in vivo;Laboratories;material transfer agreement;meningioma;Messenger RNA;Metabolic;methylome;miRNA expression profiling;Modeling;Molecular;Molecular Profiling;Mouse Cell Line;Mus;mutant;Mutate;neoplastic cell;nerve stem cell;new therapeutic target;Normal tissue morphology;novel therapeutics;Oncogenes;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;personalized medicine;Phenotype;pre-clinical;preclinical study;Primary Neoplasm;Research;Resources;screening;Serum;Signal Pathway;Signal Transduction;stem cell biology;stem cell self renewal;stem cells;Study models;System;Technical Expertise;Therapeutic;Therapeutic Agents;tool;transcriptome;transcriptome sequencing;translational study;Tretinoin;tumor;tumor initiation;Tumor Stem Cells;Tumor Suppressor Proteins;tumor xenograft;Tumor-Derived;tumorigenesis;Work

PROJECT_TITLE: Exploring the Therapeutic Potential of Stem Cell Biology in Gliomas


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

PROJECT_TERMS: Astrocytoma;Caregivers;Caring;Categories;Central Nervous System Neoplasms;Chordoma;Choroid Plexus Carcinoma;Classification;Clinical;clinical infrastructure;Clinical Trials;Collaborations;Consensus;Data Management Resources;Development;Disease;Education;Ependymoma;Evaluation;Fostering;Funding;Gene Amplification;Gene Fusion;Genomic DNA;Genomics;Glioblastoma;Glioma;Gliomatosis cerebri;Goals;Histones;imaging biomarker;Imaging technology;Immune checkpoint inhibitor;Immunologic Monitoring;immunotherapy trials;improved;Incidence;Infrastructure;International;Investigation;Joints;Knowledge;Laboratories;Malignant - descriptor;Malignant neoplasm of central nervous system;Malignant Neoplasms;Medulloblastoma;member;metabolomics;methylome;Molecular;Molecular Analysis;molecular pathology;Monitor;Monograph;mutant;Mutate;Mutation;National Cancer Institute;Natural History;Neoplasms;Nivolumab;Normal tissue morphology;oligodendroglioma;Oncology;outreach;participant enrollment;Pathogenesis;Pathology;Patient advocacy;patient advocacy group;patient engagement;Patient Participation;Patients;Pediatric Oncology;Persons;phase II trial;Phenotype;pineoblastoma;predicting response;predictive marker;Primary Brain Neoplasms;Primary Neoplasm;prognostic;programs;Proteomics;Provider;Publishing;Qualifying;rare cancer;Rare Diseases;Recruitment Activity;Regimen;Research;Research Personnel;Resources;Rhabdoid Tumor;routine imaging;Sampling;Silicon Dioxide;Testing;Therapeutic;Tissue Banks;treatment response;tumor;Tumor Biology;tumor diagnosis;Tumor Tissue;United States;United States National Institutes of Health

PROJECT_TITLE: Rare Central Nervous System Cancers Initiative


NIH_SPENDING_CATS: Cancer;Genetics

PI_NAMEs: LAL, ASHISH  (contact)

PROJECT_TERMS: Attention;Biogenesis;Biology;Cell Cycle Arrest;Cell Line;Cell Physiology;Cell Survival;Colorectal;Colorectal Cancer;DNA Damage;epigenetic regulation;Foundations;Future;Gene Expression;gene repression;Genes;Genetic Transcription;Genome;Goals;Human;human disease;Laboratories;Malignant Neoplasms;MicroRNAs;Mitotic spindle;Modeling;mRNA Precursor;mRNA Stability;mRNA Translation;Mutate;novel;Pathway interactions;Play;Post-Transcriptional Regulation;Proliferating;Regulation;Research;response;RNA Splicing;RNA-Binding Proteins;Role;Signal Transduction;TP53 gene;transcription factor;transcriptome;translational potential;Translational Research;Untranslated RNA

PROJECT_TITLE: Role of long non-coding RNAs and RNA-binding proteins in p53 signaling


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PROJECT_TERMS: 10q;11p;11q;12q13;13q;14q13;19q;1p34;1q32;20p;20q;22q;3q26;8q24;Animals;Apoptosis;Area;Astrocytoma;Automobile Driving;Binding Proteins;Bioinformatics;Biological Assay;Biology;Biotechnology;Brain;Brain Neoplasms;Cancer Genome Anatomy Project;Candidate Disease Gene;CDKN2A gene;cDNA Arrays;Cell Line;Cellular biology;Central Nervous System Neoplasms;Chromatin;chromosome 5q loss;Chromosome abnormality;Classification;Clinical;Collaborations;Complex;Data;Data Analyses;Decarboxylation;Deoxyribonuclease I;Deoxyribonucleases;Development;Dioxygenases;Disease;Disparity;DNA;enzyme activity;Enzymes;Epidermal Growth Factor Receptor;Epigenetic Process;Exhibits;experimental study;expression vector;falls;Gene Chips;gene cloning;gene discovery;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Gene Expression Regulation;Gene Silencing;Genes;Genetic;Genetic Transcription;Genome;genome-wide;Genomics;Glioblastoma;Glioma;Gliomagenesis;Goals;Heterogeneity;Human;Human Genome;Human Genome Project;immunosuppressed;In Vitro;in vivo;insight;Isocitrate Dehydrogenase;Laboratories;Learning;Link;Location;Loss of Heterozygosity;Malignant - descriptor;malignant phenotype;Methods;Methylation;Microarray Analysis;Molecular;Molecular Target;Morphology;Mutation;Neuroglia;Neurons;new technology;new therapeutic target;next generation sequencing;novel;Nuclear;Nucleic Acid Regulatory Sequences;Oncogenes;Operative Surgical Procedures;Pathologic;Patients;permissiveness;postmitotic;Process;Proliferating;Protocols documentation;PTEN gene;Receptor Biology and Gene Expression;Recurrence;Reproducibility;Role;Sampling;self-renewal;Signal Transduction Pathway;Site;SNP array;Specimen;stem cells;Structure;Testing;Therapeutic Intervention;Tissues;TP53 gene;transcription factor;transcriptome;Transplantation;tumor;Tumor Biology;Tumor Suppressor Genes;Tumor Suppressor Proteins;Tumor Tissue;tumorigenesis;tumorigenic;Work;Xenograft procedure

PROJECT_TITLE: Identifying New Glioma-Associated Tumor Suppressors and Oncogenes


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Immunotherapy;Kidney Disease;Rare Diseases

PI_NAMEs: SRINIVASAN, RAMAPRASAD  (contact)

PROJECT_TERMS: Accounting;aerobic glycolysis;Automobile Driving;Awareness;bevacizumab;Biochemical;biological adaptation to stress;Cancer Therapy Evaluation Program;Cessation of life;Citric Acid Cycle;Clear Cell;Clinical;cohort;Constitution;Dasatinib;Data;Dedications;Dependence;design;Development;Disease;disease model;Early Therapeutic-Clinical Trials Network;effective therapy;Enzymes;Erlotinib;Evaluation;forging;Foundations;FRAP1 gene;Fumarate Hydratase;Gene Family;Genes;Genetic;Genomics;Germ Lines;Hereditary Leiomyomatosis and Renal Cell Cancer;Histologic;HSP 90 inhibition;Immune checkpoint inhibitor;Individual;inhibitor;interest;International;Kidney;Laboratories;Lead;Malignant Neoplasms;Manuscripts;meetings;Metabolic;Molecular;molecular marker;Mutation;Oxidative Stress;Paper;Papillary;Pathway interactions;Patient Care;Patients;PD-1 inhibitors;PDL1 inhibitors;pharmacologic;Phase;phase 2 study;Pre-Clinical Model;programs;Publishing;Regimen;Renal Carcinoma;Renal Cell Carcinoma;Research;Research Personnel;response;standard of care;Systemic Therapy;targeted agent;TFE3 gene;Therapeutic;tongue papilla;transcription factor;translational scientist;treatment strategy;Triplet Multiple Birth;tumor;United States;Variant;Vascular Endothelial Growth Factors

PROJECT_TITLE: Targeting Genetic and Metabolic Alterations in Distinct Subtypes of RCC


NIH_SPENDING_CATS: Aging;Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Rare Diseases;Women's Health Research

PI_NAMEs: LIPKOWITZ, STANLEY  (contact)

PROJECT_TERMS: African American;Age;alpelisib;Animal Model;biobank;Blood;Blood coagulation;Breast Cancer Patient;Characteristics;Clinical;clinical center;Clinical Trials;Collaborations;Credentialing;Data;Databases;DNA;Dose;Enrollment;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Estrogen receptor negative;exome sequencing;Genomics;Germ Lines;Goals;high risk;Hospitals;human old age (65+);In Vitro;inhibitor;Malignant Breast Neoplasm;Mammary Neoplasms;Medical center;medical schools;Metaplastic carcinoma of the breast;Methodist Church;Military Personnel;Molecular;Multivariate Analysis;Nature;older women;Outcome;Paclitaxel;patient population;Patients;Phase;phase 2 study;Phase I/II Clinical Trial;PIK3CA gene;preclinical study;Prognosis;Proteomics;Publications;rare cancer;Recommendation;Research Institute;Sampling;Tissue Banks;transcriptome sequencing;tumor;United States National Institutes of Health;Woman;women's diagnosis;women's outcomes;Work;young woman

PROJECT_TITLE: Genomic characterization of breast cancer in high risk subsets of breast cancer


PI_NAMEs: YANG, JAMES C (contact)

PROJECT_TERMS: anti-PD1 antibodies;Back;Cancer Etiology;Cells;Cessation of life;Clinical;Clinical Research;Development;Disease;Human;Immune response;Immunotherapy;Laboratory Study;Malignant neoplasm of lung;Malignant Neoplasms;Mutate;Mutation;neoantigens;Non-Small-Cell Lung Carcinoma;Operative Surgical Procedures;patient subsets;Patients;Phenotype;Proteins;Publishing;Specimen;T-Lymphocyte;Testing;tumor;Tumor-Infiltrating Lymphocytes

PROJECT_TITLE: Laboratory and Clinical studies on T-cells recognizing Non-Small Cell Lung Cancer


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Precision Medicine;Rare Diseases

PI_NAMEs: ALEWINE, CHRISTINE  (contact)

PROJECT_TERMS: Abdominal Cavity;Address;advanced disease;Agonist;Angiogenesis Inhibitors;antagonist;Antibodies;Binding;Blood;Blood Vessels;cancer cell;Cancer Patient;Cell Line;Cell surface;Clinical Trials;Collaborations;Cytotoxin;Data;density;Deposition;design;Disease;Enrollment;Extramural Activities;Goals;Heart;Human;Immune;Immune system;Immunocompetent;Impairment;improved;Integrins;Interleukin-15;Knock-in;KPC model;Lung;Lymphocyte Activation;Macrophage;Malignant neoplasm of pancreas;Manuscripts;Medical;Membrane;mesothelin;Modeling;Mus;Neoplasm Metastasis;Normal Cell;novel;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pathway interactions;Patients;Penetration;Peritoneum;Pharmaceutical Preparations;Phase;Physiology;Precision therapeutics;Property;Proteins;response;Role;targeted treatment;Testing;Therapeutic;therapy resistant;Toxic effect;Transforming Growth Factor beta;tumor;Tumor Antigens;Work;wound healing

PROJECT_TITLE: Precision Therapy to Target Pancreatic Ductal Adenocarcinoma


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Gene Therapy;Genetics;Lung;Lung Cancer;Nanotechnology;Orphan Drug;Rare Diseases

PI_NAMEs: HOANG, CHUONG  (contact)

PROJECT_TERMS: 3-Dimensional;anti-cancer;Antineoplastic Agents;Bioinformatics;Biology;biomarker discovery;bioprinting;Biopsy;cancer cell;cancer type;Cell model;cell type;Cells;Characteristics;Chemicals;Chemistry;Chest;Clinical;Collaborations;combinatorial;Complex;design;Development;Diagnosis;Drug Targeting;Epigenetic Process;Evaluation;Film;functional genomics;Future;Genes;Goals;Human;human tissue;Hydrogels;in vivo;Induction of Apoptosis;innovation;insight;Interdisciplinary Study;interest;Investigation;Knowledge;Legal patent;Lesion;Malignant neoplasm of thorax;Malignant Neoplasms;Malignant Pleural Mesothelioma;manufacture;manufacturing scale-up;materials science;Membrane;Mesothelial Cell;Mesothelioma;method development;Methods;MicroRNAs;Modeling;Molecular;nanoparticle;nanoscale;neoplastic cell;next generation;Non-Small-Cell Lung Carcinoma;novel;novel drug class;Nucleic Acids;Organ;Outcome;Pathogenicity;Pathway interactions;Patients;Peptides;Performance;Pharmaceutical Preparations;Pleura;Pleural;preclinical development;preclinical study;Prognosis;Regimen;Reporting;Research;Research Project Grants;response;screening;small molecule;Surface;System;Systems Biology;Techniques;Testing;Therapeutic;therapeutic candidate;therapeutic miRNA;Thinness;Thymus Epithelial Neoplasm;Time;Tissues;tool;TP53 gene;transcription factor;Translating;Translational Research;Translations;tumor;tumor initiation;tumorigenesis;Untranslated RNA;Update;Xenograft procedure

PROJECT_TITLE: microRNA-based and novel molecular therapeutics in thoracic cancers


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Hematology;Orphan Drug;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PI_NAMEs: KANAKRY, CHRISTOPHER  (contact)

PROJECT_TERMS: Acute Graft Versus Host Disease;Allogeneic Bone Marrow Transplantation;Bone Marrow Transplantation;chimeric antigen receptor T cells;Clinic;Clinical;clinical efficacy;Clinical Research;clinical trial enrollment;Clinical Trials;cohort;conditioning;Cyclophosphamide;disorder control;Donor Lymphocyte Infusion;Dose;Drug Kinetics;Engraftment;Enrollment;Ensure;follow-up;Goals;graft vs host disease;Hematologic Neoplasms;Hematology;Hematopoietic;HLA Antigens;Human;Immune;Immunologics;improved;improved outcome;Institution;Laboratories;Laboratory Research;Major Histocompatibility Complex;Manuscripts;Mixed Lymphocyte Culture Test;Modeling;Modification;mouse model;Mus;Non-Malignant;novel strategies;Outcome;patient population;Patient-Focused Outcomes;Patients;Peripheral Stem Cell Transplantation;Phase;post-transplant;prevent;Prevention;prophylactic;Recovery;Relapse;Risk Reduction;Siblings;standard of care;stem;T-Lymphocyte;Toxic effect;Translating;Translations;transplant model;Transplant-Related Disorder;Transplantation;Work

PROJECT_TITLE: Deciphering the efficacy of posttransplant cyclophosphamide in BMT


NIH_SPENDING_CATS: Cancer;HIV/AIDS

PI_NAMEs: NICKLAUS, MARC  (contact)

PROJECT_TERMS: 2019-nCoV;Behavior;Binding Proteins;cancer initiation;Chemicals;Chemistry;Clinical;Collaborations;computer generated;cost effective;Custom;Data;Databases;Development;drug candidate;drug development;Equipment and supply inventories;functional group;Future;Generations;Germany;Growth;HIV-1;in silico;Informatics;International;knowledgebase;Language;Logic;Malignant Neoplasms;N-terminal;Nature;new therapeutic target;novel;novel therapeutics;Outcome;Paper;Peer Review;Pilot Projects;Predictive Cancer Model;Process;Productivity;Property;Publishing;Reaction;Research;Resources;Route;Running;Sampling;screening;Sister;STAT3 gene;Structure;success;Systems Biology;Testing;tumor;virtual;virtual library;web server;Work;Writing

PROJECT_TITLE: Synthetically Accessible Virtual Inventory (SAVI)


NIH_SPENDING_CATS: Cancer

PI_NAMEs: WANG, YUN XING M (contact)

PROJECT_TERMS: Award;beamline;cost;data acquisition;Data Analyses;Data Collection;In Situ;Investments;Ligands;member;Molecular;Molecular Conformation;movie;nanocrystal;new technology;pandemic disease;Phase Transition;Positioning Attribute;Preparation;Process;programs;Research;RNA;Sampling;Scientist;Site;Technology;Time;tool;Visualization;x-ray free-electron laser

PROJECT_TITLE: NCI X-ray free electron laser (XFEL) initiative


NIH_SPENDING_CATS: Cancer;Immunotherapy;Microbiome

PI_NAMEs: GOLDSZMID, ROMINA  (contact)

PROJECT_TERMS: adaptive immunity;Affect;angiogenesis;Antitumor Response;Bone Marrow;cancer therapy;Cells;chemotherapy;commensal bacteria;commensal microbes;Cues;Dendritic Cells;Development;Diet;Distant;Embryonic Development;Epithelium;Experimental Neoplasms;Fiber;Goals;gut microbiota;immune checkpoint blockade;Immune Evasion;Immune response;Immunity;Immunotherapy;improved;Individual;Infiltration;Inflammation;Inflammatory;Invaded;Lymphoid;Macrophage;Mammals;Metabolism;microbiota;Modeling;Molecular;monocyte;Mononuclear;Mus;Myeloid Cells;Natural Immunity;Nature;Neoplasm Metastasis;novel;novel therapeutic intervention;Outcome;pathogen;Pathologic;Pathway interactions;Phagocytes;Play;Population;Population Control;programs;Regulation;Resistance;Resolution;response;Role;Science;Signal Transduction;subcutaneous;Surface;System;systemic inflammatory response;Tissues;Transcriptional Regulation;tumor;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;Vitamin D;Work

PROJECT_TITLE: Role of the microbiota in regulating the mononuclear phagocyte system


NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Prevention;Prostate Cancer;Radiation Oncology;Urologic Diseases

PI_NAMEs: SOWALSKY, ADAM  (contact)

PROJECT_TERMS: androgen deprivation therapy;ATAC-seq;Automobile Driving;Biochemical;Biopsy;Characteristics;Clinical;Development;Early Diagnosis;exome;exome sequencing;Genomics;Goals;Hormones;Image;laser capture microdissection;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;Microarray Analysis;Molecular;Neoadjuvant Therapy;Outcome;participant enrollment;Patients;Population;prevent;radiation response;Radiation therapy;Recurrence;Specimen;surveillance study;Survival Rate;Therapy Clinical Trials;Time;Tissues;transcriptome sequencing;tumor;ultrasound;whole genome

PROJECT_TITLE: Molecular alterations driving the development of primary prostate cancers


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Prevention;Prostate Cancer;Radiation Oncology;Urologic Diseases

PROJECT_TERMS: Alleles;androgen deprivation therapy;androgen independent prostate cancer;Biochemical;Biological Assay;Blood;cancer recurrence;cell free DNA;ChIP-seq;Chromatin;Clinical Trials;cohort;Coupled;Detection;Diagnosis;Disease;DNA analysis;Enrollment;genome sequencing;Goals;Malignant neoplasm of lung;Malignant neoplasm of prostate;Metastatic Prostate Cancer;Methods;Neoadjuvant Therapy;Patients;Plasma;Point Mutation;Radiation therapy;Radical Prostatectomy;Recurrence;Sampling;Screening for Prostate Cancer;Specimen;Staging;Testing;treatment response;tumor DNA;whole genome

PROJECT_TITLE: Detection of prostate cancer using circulating tumor DNA


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention

PI_NAMEs: KEARNEY, MARY  (contact)

PROJECT_TERMS: Acceleration;Affect;Anatomy;antiretroviral therapy;Binding;Biological Assay;CD4 Positive T Lymphocytes;Cell Survival;cell type;Cells;Cellular biology;Child;Chromosomes;Clonal Expansion;Clone Cells;Collecting Cell;coping;Data;detection assay;Family;follow-up;Frequencies;gene product;Gene Proteins;Genes;Genetic;Genetic Recombination;Genome;genome sequencing;HIV;HIV Genome;HIV Infections;homologous recombination;improved;in vivo;innovation;integration site;Interruption;Investigation;Length;Location;lymph nodes;Malignant Neoplasms;Manuscripts;Memory;Meta-Analysis;Methods;Mutation;novel;Participant;Patients;Play;Population;Preparation;pressure;Proliferating;Proteins;Provirus Integration;Proviruses;public database;Research;Role;Sampling;Science;self-renewal;Site;Source;Structure;T memory cell;T-Lymphocyte;T-Lymphocyte Subsets;telomere;Time;Tissues;Update;Viral;Viremia;Virion;Virus Replication;web page;Zinc Fingers

PROJECT_TITLE: Dynamics and Genetics of HIV Proviruses Before and During Antiretroviral Therapy


PI_NAMEs: WEIGERT, ROBERTO  (contact)

PROJECT_TERMS: 3-Dimensional;Ablation;Actins;Actomyosin;Affect;Animals;Area;Autophagocytosis;Behavior;Biological Models;Cancerous;Carcinogens;Carcinoma;Cell Culture Techniques;Cell membrane;cell motility;Cell Physiology;Cell Shape;Cells;Cellular Membrane;Cellular Morphology;Characteristics;Collagen;Complex;Confocal Microscopy;Cytoplasmic Granules;Cytoskeleton;Data;Data Analyses;Development;Endocytosis;Ensure;Environment;Epidermal Growth Factor Receptor;Epithelial Cells;Epithelium;Event;Exhibits;Exocytosis;Extracellular Matrix;Extracellular Space;Extravasation;ezrin;F-Actin;Family;Filament;Genes;Genetic;Glycolysis;Goals;Growth;Guanosine Triphosphate Phosphohydrolases;Head and Neck Squamous Cell Carcinoma;healing;Immune;immune activation;Immune response;Impairment;In Situ;in vivo;Infection;Infiltration;Inflammatory;interstitial;Invaded;Investigation;Lesion;light microscopy;Link;Lipids;Machine Learning;Maintenance;Measurement;mechanical force;member;Membrane;Mesenchymal;Metabolic stress;Metabolism;Methods;Microfilaments;Microscopy;migration;Modeling;Molecular;Monomeric GTP-Binding Proteins;Morphology;Mouse Strains;Myeloid Cells;Myosin Type II;NADH;Neoplasm Metastasis;neoplastic cell;neutrophil;non-muscle myosin;novel;Nutrient;Organ Culture Techniques;Oxidative Phosphorylation;Pathologic;Patients;pharmacologic;Phase;Physiological;PIK3CG gene;Play;polymerization;Polymers;premalignant;Process;Protein Isoforms;Proteins;recruit;Resolution;Rodent;scaffold;Secretory Vesicles;Series;Severe dysplasia;Shapes;Signal Transduction;spatiotemporal;System;Techniques;Tissues;tool;trafficking;tumor;tumor growth;tumor initiation;tumor progression;tumorigenic;two-photon;Visualization;wound

PROJECT_TITLE: Molecular mechanisms of membrane remodeling