NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Prevention;Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: OAKLAND UNIVERSITY

PHR: This grant renewal proposal addresses critical scalability of the emerging magnetic particle imaging (MPI) technique that utilizes magnetic nanoparticle traces for in vivo imaging. We will develop a novel MPI scanner in a single-sided geometry to be potentially translated to humans. By developing this new scanner, we hope to offer a new ultrasensitive, fast, and safe diagnostic tool for screening and biopsy of breast cancer.

PI_NAMEs: TONYUSHKIN, ALEXEY A (contact)

PROGRAM_OFFICER_NAME: WANG, SHUMIN

PROJECT_TERMS: 3-Dimensional;Address;Angiography;Animals;Automation;Back;Body part;Breast biopsy;Breast Cancer Detection;Breast Cancer Early Detection;breast imaging;cancer cell;Cancer Detection;Cancer Diagnostics;cancer imaging;Cells;chemotherapy;Clinical;clinical application;clinical practice;clinical translation;clinically relevant;Complex;Coupling;Data Collection;design;Detection;Devices;Diagnostic;Diagnostic Imaging;Diagnostic Procedure;diagnostic tool;diagnostic value;Dimensions;Disease;Disseminated Malignant Neoplasm;Drug Delivery Systems;Electronics;Engineering;Environment;Functional Imaging;Future;Geometry;Goals;Grant;Height;Human;Human body;Hybrids;Image;image reconstruction;imager;Imaging Device;imaging modality;imaging study;Imaging Techniques;improved;In Vitro;in vivo;in vivo imaging;Institution;Ionizing radiation;magnetic field;Magnetic nanoparticles;Magnetic Resonance Imaging;Magnetism;Malignant Breast Neoplasm;Mammography;Mechanics;mouse model;Mus;nanoparticle;Noise;novel;Operative Surgical Procedures;particle;patient population;Penetration;Performance;power consumption;Power Sources;programs;prototype;Research;Resolution;response;Rodent;Rotation;scale up;screening;Screening for cancer;Screening procedure;Side;Signal Transduction;Slice;Source;spatiotemporal;Techniques;Three-Dimensional Imaging;tomography;tool;Tracer;Translating;treatment planning;tumor;undergraduate student;Universities;uptake;Women's Health

PROJECT_TITLE: A Single-Sided Magnetic Particle Imaging Scanner for In Vivo Breast Cancer Imaging

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Huntington

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTHER BASIC SCIENCES

ORG_FIPS: US

ORG_NAME: MARSHALL UNIVERSITY

ORG_STATE: WV

PHR: WV-INBRE supported research projects will investigate several major human health issues that are particularly prevalent in West Virginia including cancer, cardiovascular disease, diabetes, obesity-related illness and addiction. An important aspect of WV-INBRE is directed toward enhancing the pipeline of undergraduate and graduate students choosing a career in the biomedical science research field.

PI_NAMEs: GOZAL, DAVID  (contact)

PROGRAM_OFFICER_NAME: MATUKUMALLI, LAKSHMI KUMAR

PROJECT_TERMS: Academy;addiction;Award;base;Biomedical Research;Cardiovascular Diseases;career;career development;Cellular biology;Centers of Research Excellence;Chronic Disease;Collaborations;Core Facility;Data Science;Development;Diabetes Mellitus;Doctor of Philosophy;Educational workshop;Evaluation;experience;Faculty;faculty research;Funding;graduate student;Grant;Health;health science research;Health Sciences;Health Technology;high school;Human;Infrastructure;Institution;Interdisciplinary Study;Knowledge;Lead;Malignant Neoplasms;Mentors;Minority Recruitment;Minority-Serving Institution;Molecular;Molecular Biology;multidisciplinary;National Center for Research Resources;Natural Products;Network Infrastructure;Obesity;Phase;Pilot Projects;Postdoctoral Fellow;Principal Investigator;Program Research Project Grants;programs;Puerto Rico;Recording of previous events;Research;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Research Training;Science;science teacher;skills;Structure;Students;success;summer research;summer student;symposium;Technology;Training;undergraduate research experience;undergraduate student;United States National Institutes of Health;Universities;virtual;West Virginia

PROJECT_TITLE: West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-9 (IN)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PHR: The Administrative Core (AC) of WV-INBRE is a highly interactive Core for administering the day-to-day operations of the network, developing research network components and providing support for the research network. Through the interactions of the Steering and Executive Committees working with WV-INBRE leadership and input from the External Advisory Committee, the AC will oversee and grow biomedical research infrastructure and capacity across West Virginia.

PI_NAMEs: RANKIN, GARY O (contact)

PROJECT_TERMS: Academy;Advisory Committees;Award;base;Biomedical Research;career;Centers of Research Excellence;Clinical Sciences;Data Science;Data Science Core;Development;Disadvantaged;diversity and inclusion;Educational workshop;Equipment;Evaluation;Faculty;faculty research;Funding;Goals;graduate student;Grant;Growth;Growth and Development function;Health;Health Sciences;Health Technology;High School Student;improved;Infrastructure;Institution;Interdisciplinary Study;Knowledge;Lead;Leadership;meetings;member;Mentors;Minority;Minority-Serving Institution;Mission;Molecular;Monitor;operation;Phase;Postdoctoral Fellow;Program Development;Program Research Project Grants;programs;Research;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Research Training;Science;science education;STEM research;Students;success;summer research;Technology;Training;training opportunity;Translational Research;Travel;undergraduate student;United States National Institutes of Health;Universities;webinar;West Virginia;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Natural Products

PHR: The Development Research Project Program will provide research funding to PUI network investigators to conduct biomedical research projects with a focus on chronic diseases an provide opportunities for student training in biomedical research. Included in these programs are pilot project programs that focus on natural products research in chemotherapy, including a new collaborative initiative with investigators in the Puerto Rico INBRE.

PI_NAMEs: HILEMAN, STANLEY M. (contact)

PROJECT_TERMS: Area;Award;base;Biomedical Research;chemotherapy;Chronic Disease;Collaborations;Data;design;Development;Eligibility Determination;experience;Faculty;faculty research;Funding;Goals;Grant;Growth;Heart;Home;infectious disease chemotherapy;Institution;Malignant Neoplasms;Mississippi;Natural Products;Phase;Pilot Projects;Principal Investigator;Program Research Project Grants;programs;Puerto Rico;Research;research and development;Research Infrastructure;Research Personnel;Research Project Grants;skill acquisition;student training;Students;undergraduate student;Universities;West Virginia

PROJECT_TITLE: Development Research Project Program


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PHR: Data Science Core Project Narrative The Data Science Core (DSC) is a centralized resource that provides training, services, and expertise in data science, machine learning, artificial intelligence, and related technologies. These services and expertise will allow investigators to use these technologies to enhance their understanding of the mechanisms of disease and lead to the discovery of novel treatments.

PI_NAMEs: DENVIR, JAMES  (contact)

PROJECT_TERMS: Appalachian Region;Artificial Intelligence;artificial intelligence algorithm;Award;Big Data;Bioinformatics;biomedical data science;Biomedical Research;career;Cells;Chromatin;Chronic Disease;Cloud Computing;cluster computing;Collaborations;computer infrastructure;computing resources;Core Facility;cyber infrastructure;Data;Data Analyses;Data Analytics;data management;Data Science;Data Science Core;Disease;Doctor of Philosophy;E-learning;Educational workshop;empowerment;exome;Experimental Designs;Faculty;flexibility;Freedom;Funding;Genomics;Goals;graduate student;High Performance Computing;Infrastructure;Institution;instructor;Laboratories;Lead;Learning Module;Libraries;Machine Learning;microbiome;Molecular;Network Infrastructure;next generation;next generation sequencing;novel;Ohio;Phase;Pilot Projects;Postdoctoral Fellow;Preparation;programs;Research;Research Personnel;Resources;Science;Series;Service provision;Services;Source;statistical learning;statistics;Students;summer program;supercomputer;Technical Expertise;Techniques;Technology;therapy development;Training;Training Activity;Training and Education;transcriptome sequencing;transcriptomics;undergraduate education;undergraduate student;Universities;West Virginia;whole genome

PROJECT_TITLE: Data Science Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome

PHR: The Sequencing, Molecular and Related Technologies (SMART) Core is a centralized resource that provides genomic research services, access to genomic and nucleic acid analysis instrumentation, and support for the analysis of genomic data. These technologies and service will help investigators identify genes associated with a particular disease and/or the proper function of normal tissue and lead to the discovery of novel therapeutics.

PI_NAMEs: SALISBURY, TRAVIS  (contact)

PROJECT_TERMS: Address;Adopted;Appalachian Region;Applications Grants;base;Bioinformatics;biological research;Biomedical Research;Businesses;Candidate Disease Gene;Cells;Centers of Research Excellence;Chromatin;Chromatin Structure;Chronic Disease;clinical translation;Collaborations;Computer software;Consultations;Core Facility;cost;cryostat;Data;Data Analyses;Data Science Core;design;Development;Disease;DNA;Educational workshop;Elements;Equipment;exome;experience;Experimental Designs;experimental study;Fostering;Funding;gene function;Genes;genome-wide analysis;Genomic approach;genomic data;Genomics;Goals;Grant;Human Resources;imaging system;Improve Access;improved;Individual;Infrastructure;insight;Institution;instrument;instrumentation;Investigator-Initiated Research;Lead;Maintenance;Methods;microbiome;Modeling;Modernization;Molecular;new technology;next generation sequencing;Normal tissue morphology;novel therapeutics;Nucleic Acids;Obesity;Outcome;Pathway interactions;Phase;Preparation;Process;Program Research Project Grants;programs;Qualifying;Reader;Research;Research Personnel;Research Project Grants;Resources;RNA;RNA Sequence Analysis;Role;Science;Service delivery model;Services;Strategic Planning;Technology;Testing;Time;Training;transcriptome;transcriptome sequencing;transcriptomics;Translational Research;undergraduate student;West Virginia;whole genome;Work

PROJECT_TITLE: SMART Core


PHR: The renovations proposed here will create a collaborative biomedical research suite that provides more opportunities for student-driven research and support the development of an undergraduate biomedical research major, a unique major not currently offered at any primarily undergraduate institution in the state of West Virginia.

PI_NAMEs: SCHMITT, DEANNA MARIE (contact)

PROJECT_TERMS: Area;biological research;Biological Sciences;Biology;Biomedical Research;Dedications;Development;Ecology;Educational Curriculum;Equipment;experience;Faculty;falls;Freedom;Funding;Future Generations;graduate student;Growth;Health Personnel;Hour;improved;Institution;Laboratories;Laboratory Research;Mentors;Output;Physicians;programs;Research;research faculty;Research Project Grants;Science;Scientist;square foot;student participation;Students;Time;Training;undergraduate research;undergraduate student;Universities;West Virginia

PROJECT_TITLE: Alt & Reno Core


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

ORG_CITY: SAN ANTONIO

ORG_DEPT: CHEMISTRY

ORG_NAME: TRINITY UNIVERSITY

ORG_STATE: TX

PHR: Project Narrative Reactive Oxygen Species include molecules such as superoxide, peroxide and hydroxyl radicals. High levels of these molecules have been shown to lead to diseases such as heart disease, cancer, and neurodegenerative diseases. The proposal aims to determine if the reduction potential of the Rieske protein in Complex III can be a source of superoxide when the reduction potential is not matched to its redox partner.

PI_NAMEs: HUNSICKER-WANG, LAURA  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Biological;Biological Assay;Cells;Charge;Chemical Modifier;cofactor;Collaborations;Communication;Confocal Microscopy;Cysteine;Cytochrome c1;design;Diabetes Mellitus;Diethyl Pyrocarbonate;Disease;Disease Progression;Electrochemistry;Electron Transport Complex III;Electrons;experience;flexibility;Fluorescent Dyes;Functional disorder;Gel;graduate school;Growth;Heart Diseases;Histidine;Hydroquinones;Hydroxyl Radical;in vivo;Iron;Learning Skill;Life;Ligation;Literature;Malignant Neoplasms;Measures;mutant;Mutation;Neck;Neurodegenerative Disorders;novel;Occupations;Ownership;Oxidation-Reduction;Peroxides;Play;Production;protein expression;protein purification;Protein Region;Proteins;Reaction;Reactive Oxygen Species;Research;Research Personnel;Role;Science;semiquinone;Series;Signaling Molecule;skills;small molecule;Source;Spectrum Analysis;Sulfur;Superoxides;System;Technical Expertise;Testing;Thermus thermophilus;undergraduate student;Yeasts

PROJECT_TITLE: Probing the potential role of the Rieske protein in superoxide formation in Complex III

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: HG

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: NEW YORK

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

ORG_STATE: NY

PHR: While further the goals of the parent award, this diversity supplement will help to increase representation of LGBTQ+ people in STEM.

PI_NAMEs: DRNDIC, MARIJA ;SHEPARD, KENNETH L (contact)

PROGRAM_OFFICER_NAME: NOVA, IAN CURTIS

PROJECT_TERMS: Electrostatics;Goals;graduate student;Lesbian Gay Bisexual Transgender Queer;nanopore;parent project;Persons;Science;solid state;Underrepresented Populations

PROJECT_TITLE: Enzymeless, controlled electrostatic ratcheting in solid-state nanopores


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Public Health Relevance. The proposed Center addresses the need to strengthen the capacity of informal caregivers of persons living with Alzheimer’s and similar illnesses to provide guidance and care to those individuals and, therefore, enable them to live in the community and not in institutional settings for as long as possible. Addressing the need to promote caregiving mastery in heterogeneous caregiving contexts is central to the quality of life of those living with these illnesses and may contribute to restraining the growth in health care expenditure associated with them. The Center will support the design, development, implementation, and stage-advancement of mechanism-based behavioral intervention clinical trials, especially stage I and II trials, proposed by researchers across the country and aimed at specific caregiving contexts.

PI_NAMEs: HEPBURN, KEN W (contact);PERKINS, MOLLY M

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Acute;Address;Alzheimer's Disease;Alzheimer's disease caregiver;American;Behavior;behavior change;behavior test;Behavior Therapy;Behavioral Mechanisms;Behavioral Model;Capital;care recipients;caregiver interventions;Caregiver research;Caregiver well-being;Caregivers;caregiving;caregiving research;Caring;Chronic;clinical center;Clinical Trials;Collaborations;collaboratory;Communication;Communities;community living;comorbidity;Consult;Consultations;Country;Dementia;Dementia caregivers;dementia caregiving;design;Development;disease heterogeneity;Education;Elderly;Elements;Ensure;ethnic diversity;Ethnic Origin;Evidence based intervention;experience;Family;Family Caregiver;Fostering;Funding;Geographic Locations;Geriatrics;Gerontology;Goals;Grant;Growth;Health Care Costs;Health Expenditures;Heterogeneity;Human Resources;Individual;informal caregiver;informal caregiving;Infrastructure;Institution;Interest Group;Intervention;intervention program;Intervention Studies;Intervention Trial;Investments;Latino;Location;Managed Care;Medical;Mentors;Methods;Minority;Modeling;Monitor;Persons;Play;Politics;Process;programs;psychoeducation;public health relevance;Quality of life;Research;Research Personnel;Rest;restraint;Role;Science;Science Enrichment;Self Efficacy;Services;social;social cognitive theory;Structure;success;symposium;symptomatology;Testing;therapy design;therapy development;Time;United States National Institutes of Health;Universities;uptake;webinar;Work

PROJECT_TITLE: Roybal Center for Dementia Family Caregiver Mastery

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-4 (J3)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Dementia;Neurodegenerative;Neurosciences;Palliative Care;Prevention

PI_NAMEs: HEPBURN, KEN W (contact)

PROJECT_TERMS: Address;Alzheimer's Disease;Award;Awareness;Basic Science;behavior change;Behavior Therapy;Behavioral Mechanisms;Behavioral Sciences;Behavioral trial;care recipients;Caregiver research;Caregiver support;Caregivers;caregiving;clinical center;Clinical Trials;Collaborations;collaboratory;Communication;Communities;Contracts;Country;Dementia;dementia caregiving;design;Development;Discipline of Nursing;Documentation;Education;Educational workshop;effective intervention;Elderly;Ensure;Evaluation;experience;Family Caregiver;Funding;Generations;Goals;Heterogeneity;Human Resources;improved;Incubated;informal caregiving;innovation;Institution;interest;Interest Group;Intervention;intervention program;Intervention Studies;Intervention Trial;Investments;Latino;Leadership;Letters;Maintenance;meetings;member;Mentors;Modeling;Monitor;National Institute on Aging;operation;Outcome Assessment;Play;Process;public health research;Reporting;Research;Research Personnel;Resources;Role;Schedule;School Nursing;Science;senior faculty;Services;social interventions;Structure;success;successful intervention;symposium;Testing;therapy development;Travel;United States National Institutes of Health;Vision;web site;webinar;Work


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Prevention

PI_NAMEs: EPPS, FAYRON RECHA (contact)

PROJECT_TERMS: Address;Behavior Therapy;Capsicum;Caregivers;caregiving;Clinical Trials;Collaborations;collaboratory;Consult;Consultations;Critiques;Dementia;dementia caregiving;design;Development;Development Plans;Ensure;evidence base;Evidence based intervention;experience;Family Caregiver;Generations;Goals;Human Resources;human subject;Individual;interest;Intervention;Intervention Trial;Investments;Language;Latino;Leadership;Letters;meetings;member;Mentors;Methods;Monitor;Nursing Research;Office Nursing;Outcome;Pathway interactions;Preparation;Process;programs;Progress Reports;psychoeducation;Recommendation;Research;Research Personnel;Resources;response;Role;Science Enrichment;Secure;Series;Services;Source;Spanish;Structure;Study Section;Study Subject;success;Telephone;Testing;therapy development;trial design;United States National Institutes of Health;videoconference;Work;Writing

PROJECT_TITLE: Behavioral Intervention Development Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Genetics;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: CORAL GABLES

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Narrative: Synaptic damage is associated with many neurodegenerative diseases and traumatic injuries; however, the underlying pathologies that lead to synaptic damage and losses are poorly defined. Our studies examine how prolonged release of D-serine by microglia leads to synaptic damage through hyper-activation of NMDA receptors that target dendritic spines for degradation and pruning in both murine and human tissues.

PI_NAMEs: LIEBL, DANIEL JON (contact);WOLOSKER, HERMAN

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Acceleration;Acute;Address;Aging;Agonist;Alzheimer's Disease;Amino Acid Transporter;Amino Acids;Astrocytes;Attention;Autopsy;Behavior;behavior measurement;Brain;brain cell;brain circuitry;Brain Injuries;Cells;Cellular Structures;central nervous system injury;Cognition;Cognitive;cognitive function;Complement;Complex;Conscious;Dementia;Dendritic Spines;Electrophysiology (science);Event;experimental study;extracellular;Functional disorder;Gene Targeting;Genetic;Genetic Techniques;Glycine;high resolution imaging;Human;human model;human tissue;Huntington Disease;Imaging Techniques;Impaired cognition;in vivo;injured;Injury;interdisciplinary approach;Intervention;laser capture microdissection;Link;Mediating;Mediator;Microdialysis;Microglia;Modeling;mouse model;Mus;N-Methyl-D-Aspartate Receptors;neural;Neurodegenerative Disorders;Neuroglia;Neurons;neurotransmission;novel;novel therapeutics;Nuclear RNA;Parkinson Disease;Pathologic;Pathology;Patients;pharmacologic;Phase;Play;preservation;Process;Research Personnel;response;Rodent;Role;Serine;Source;Synapses;Synaptic plasticity;Synaptic Transmission;Tissues;transcriptome sequencing;transcriptomics;Translating;translational potential;Traumatic Brain Injury;Traumatic injury;United States National Institutes of Health

PROJECT_TITLE: Stabilizing the Tripartite Synaptic Complex Following TBI

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome

ORG_CITY: BOSTON

ORG_DEPT: GENETICS

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Although peritoneal metastasis is one of the most lethal forms of colorectal cancer progression, with few treatment options available to affected patients, little is known about the origins and the biology of the disease. With a strong inter-disciplinary team consisting of clinicians, geneticists and computational biologists, we propose to investigate the paths by which peritoneal metastases are seeded, what their genetic characteristics are, and how their microenvironment correlates with disease progression. Results from this study will provide a much-needed rational basis for the development of new surgical and medical treatment approaches.

PI_NAMEs: NAXEROVA, KAMILA  (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: Academic Medical Centers;Affect;Aneuploid Cells;Area;Basic Science;Biological;Biology;cancer cell;Cells;Characteristics;Clinical;clinical care;cohort;Collaborations;Collection;Colon;Colon Carcinoma;Color;Colorectal Cancer;colorectal cancer progression;Data;design;Development;Diagnosis;Disease;Disease Progression;Distant;Distant Metastasis;driver mutation;Environment;Evolution;Excision;exome;exome sequencing;Exposure to;fluid flow;follow-up;Genetic;Genetic study;Genetic Variation;genome sequencing;Genomic Segment;Genomics;Goals;Greater sac of peritoneum;Growth;Hematogenous;Hyperthermia;Immune;Immunofluorescence Immunologic;Immunologic Surveillance;insight;International;intraperitoneal therapy;Invaded;Lesion;Liver;Lung;Maps;Measures;Medical;Metastatic Neoplasm to the Liver;Metastatic Neoplasm to the Lung;Microsatellite Repeats;Molecular Profiling;Mutate;Mutation;Neoplasm Metastasis;novel therapeutic intervention;Operative Surgical Procedures;Organ;Outcome;Patient Selection;patient subsets;Patients;Peritoneal;Peritoneal Diseases;Peritoneal Fluid;Peritoneum;Phylogenetic Analysis;pressure;Primary Neoplasm;Procedures;Prognosis;Prognostic Factor;prospective;Publishing;reconstruction;Recording of previous events;Relapse;Research;Retrospective cohort;Role;Route;Sampling;Serous Membrane;Shapes;single nucleus RNA-sequencing;Site;Soil;Stromal Cells;study characteristics;survival outcome;transcriptome;tumor;Tumor Debulking;tumor growth;tumor microenvironment;whole genome

PROJECT_TITLE: Defining the role of seed and soil in peritoneal metastasis evolution

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: Chicago

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Overall Narrative Our proposed UIC Midwest Roybal Center for Health Promotion and Translation seeks to turn the findings of behavioral research interventions into real-world ways of improving the physical and brain health and quality of life of older adults at risk of Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD). Our renewal Center will continue to design interventions for older racial/ethnic minority adults while expanding our focus to reach those at risk of AD/ADRD using interventions that address brain health. This renewal application has four focus areas: 1) develop and test interventions to increase physical activity among older adults at risk of ADRD; 2) design interventions to maintain or improve brain health and mobility; 3) use technology to improve intervention delivery and quality; and 4) target mechanisms of behavior change to foster lasting lifestyle change.

PI_NAMEs: BHATT, TANVI  (contact);MARQUEZ, DAVID X

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Acceleration;Acute;Address;Adult;Advisory Committees;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Behavior;behavior change;Behavior Therapy;Behavioral;Behavioral Mechanisms;Behavioral Research;brain health;Center Core Grants;Clinical Trials;Cognition;Cognitive;Cognitive aging;cognitive enhancement;cognitive function;Collaborations;Committee Members;Communities;design;Development;Diet;disability;ethnic minority;Evaluation;experience;Faculty;Family;Fostering;functional improvement;Funding;Goals;Grant;Health;Health behavior;Health Promotion;Healthcare Systems;Illinois;Image;Impaired cognition;implementation research;implementation science;improved;Individual;Infrastructure;Intervention;intervention delivery;Knowledge;Life Style;Maintenance;Memory;Methodology;Midwestern United States;Minority;Mission;Modeling;Monitor;multimodality;Neighborhoods;older adult;operation;Outcome;Performance;Phase;phase 2 study;Physical activity;physical conditioning;Population;pragmatic implementation;Process;Program Development;programs;Provider;Public Health;Qualifying;Quality of life;racial minority;Research;Research Methodology;Research Personnel;Risk;Risk Factors;Risk Reduction;Science;sedentary lifestyle;sound;Specific qualifier value;statistics;stress reduction;Technology;Testing;theories;therapy design;therapy development;translational progress;Translations;United States National Institutes of Health;Universities;Work


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Prevention

PHR: Administrative Core Narrative Our proposed UIC Midwest Roybal Center for Health Promotion and Translation seeks to turn the findings of behavioral research interventions into real-world ways of improving the physical and brain health and quality of life of older adults at risk of Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD). The Administrative Core will play a vital role in ensuring that our renewal Center achieves its mission by enrolling key members of the policy, academic, and practice communities into our External Advisory Committee and by engaging outstanding UIC faculty as members of our Executive Committee.

PI_NAMEs: MARQUEZ, DAVID X (contact)

PROJECT_TERMS: Achievement;Advisory Committees;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;behavior change;Behavior Therapy;Behavioral;Behavioral Mechanisms;Behavioral Research;brain health;Characteristics;Chicago;Clinical Trials;Code;Cognitive;Cognitive aging;cognitive enhancement;cognitive function;Communities;Community Practice;design;Development;Diet;Enrollment;Ensure;Faculty;Fostering;functional improvement;Funding;Goals;Health;Health Promotion;improved;interest;International;Intervention;Intervention Studies;Knowledge;Life Style;meetings;member;Midwestern United States;Mission;Modeling;Monitor;Monitoring Clinical Trials;older adult;Peer Review;Physical activity;physical conditioning;Physical Function;Play;Policies;Population;programs;Progress Reports;Publications;Quality of life;Research;Research Personnel;Risk;Role;Science;Scientific Advances and Accomplishments;Site;Specific qualifier value;Standardization;statistics;Strategic vision;stress reduction;Talents;Technology;Testing;therapy design;therapy development;Translations;Travel;United States National Institutes of Health;Work

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Complementary and Integrative Health;Dementia;Neurodegenerative;Neurosciences;Nutrition;Physical Activity;Prevention;Rehabilitation

PHR: Behavioral Intervention Development (BID) Core Narrative Our proposed UIC Midwest Roybal Center for Health Promotion and Translation seeks to turn the findings of behavioral research interventions into real-world ways of improving the physical and brain health and quality of life of older adults at risk of Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD). Our BID Core will enable us to achieve that goal by identifying talented investigators and providing them with mentoring, support, and incentives that will enable them to test impactful interventions. Interventions that we support will be highly feasible for immediate translation and implementation into practice while advancing science in our areas of thematic focus.

PI_NAMEs: MA, JUN  (contact)

PROJECT_TERMS: Activities of Daily Living;Address;Advisory Committees;Aerobic;Aerobic Exercise;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;behavior change;Behavior Therapy;Behavioral;Behavioral Mechanisms;Behavioral Research;Biological Markers;brain health;Clinical Trials;Cognition;Cognitive;Cognitive aging;cognitive enhancement;cognitive function;community partners;Counseling;Coupled;Dance Therapy;Data;dementia risk;Diet;Dietary Intervention;Eligibility Determination;executive function;Exercise;exercise intervention;follow-up;Funding;Goals;Growth Factor;Health;Health Promotion;high risk;high risk population;Homocysteine;Image;Impaired cognition;improved;Incentives;Individual;Insulin;Intervention;Latino Population;Life;Life Style;Light;Literature;Magnetic Resonance Imaging;Maintenance;Measures;Memory;Mentors;Midwestern United States;mild cognitive impairment;Modeling;Monitor;Multimodal Imaging;multiple sclerosis patient;older adult;Outcome;Parkinson Disease;Pathway interactions;Persons;Physical activity;physical conditioning;prevent;Process;programs;Quality of life;Research Personnel;Risk;Sampling;Science;social cognitive theory;strength training;stress reduction;success;Talents;Targeted Research;Technology;Testing;therapy design;therapy development;tool;Translating;Translations;Treatment Efficacy;United States National Institutes of Health

PROJECT_TITLE: BID Core


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics

ORG_CITY: WORCESTER

ORG_NAME: COLLEGE OF THE HOLY CROSS

PHR: The program aims to understand how protein splicing enzymes, or inteins, conditionally catalyze the splicing reaction under environmental cues of salinity, redox state, temperature, or pressure. Given that inteins are used in protein engineering and as biosensors, this understanding of their structure and function could lead to development of better tools for biomedical research. The program also aims to develop small molecule inhibitors of the splicing process, which could lead to the discovery of drugs that block the activity of key proteins in pathogenic fungi and mycobacteria as well as environmentally toxic cyanobacteria.

PI_NAMEs: MILLS, KENNETH V (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Active Sites;Address;Affect;Alleles;Archaea;Binding Sites;Biochemical;Biological Assay;Biomedical Research;Biophysical Process;Biosensor;Biotechnology;Categories;chemical reaction;Chemicals;cost;Cues;Cyanobacterium;design;Development;Directed Molecular Evolution;Drug Design;drug discovery;Drug Targeting;endonuclease;Environment;environmental change;Enzymatic Biochemistry;enzyme activity;Enzymes;Equilibrium;Escherichia coli;Excision;Exhibits;Exteins;extreme halophile;fitness;Fluorescence;Fluorescence Anisotropy;Genes;genetic manipulation;Genus Mycobacterium;Goals;Growth;Homing;human pathogen;In Vitro;in vivo;inhibitor;insight;intein;Interruption;Ions;Learning;Length;Metals;Methods;Molecular;Mutation;novel;Organism;Outcome;overexpression;Oxidation-Reduction;Parasites;pathogenic fungus;Pharmaceutical Preparations;Physiological;Play;Population;pressure;prevent;Process;programs;Protein Engineering;protein folding;Protein Splicing;protein structure;Proteins;Reaction;Regulation;Research Personnel;RNA Splicing;Role;Saline;screening;Site-Directed Mutagenesis;small molecule;small molecule inhibitor;Sodium Chloride;Stress;structural biology;Structure;Temperature;thermophilic organism;tool;Toxic effect;Trans-Splicing;undergraduate student

PROJECT_TITLE: The Regulation of Inteins: Adaptations in Extremophiles and Targets for Drug Discovery


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases;Machine Learning and Artificial Intelligence;Vector-Borne Diseases

ORG_CITY: EAU CLAIRE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN EAU CLAIRE

ORG_STATE: WI

PHR: PROJECT NARRATIVE Schistosomiasis is a devastating snail-transmitted parasitic disease of poverty that inﬂicts over 250 million people around the globe. Although host-seeking and infection of snails by larval parasites is a critical chokepoint for the parasite life cycle, the behavioral details and molecular determinants of this process are poorly described, limiting novel approaches for disease control strategies that could target the snail-infective stage. Using cutting-edge experimental technologies and advanced analytical tools, we will describe the snail cues and parasite behaviors that lead to snail infection, setting the stage for high-throughput screening regimens that discover new chemicals for parasite control.

PI_NAMEs: WHEELER, NICOLAS J (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: advanced analytics;analytical tool;Animals;Area;Behavior;behavior change;Behavioral;behavioral phenotyping;burden of illness;Chemicals;chronic infection;Code;Community Health;comparative;Computer Vision Systems;computerized tools;Conscious;Consensus Sequence;Country;Cues;Custom;Data;deep learning;deep learning model;density;Detection;Development;Devices;Disease;disorder control;Esthesia;Etiology;experience;experimental study;Fingerprint;Foundations;Fractionation;functional genomics;Future;Generations;Genes;Genetic;Genomics;global health;glycosylation;Habitats;helminth infection;high throughput screening;Hot Spot;Human;Image;in vivo;Income;Infection;Interruption;Invertebrates;Investigation;Investments;knock-down;Laboratories;Life Cycle Stages;Location;Modality;Modeling;Molecular;Movement;Nature;neglect;neglected tropical diseases;novel strategies;Parasite Control;Parasites;Parasitic Diseases;Penetration;Peptides;Persons;Pharmaceutical Preparations;Plants;Platyhelminths;Population;Positioning Attribute;Poverty;Praziquantel;Prevalence;Process;rate of change;Recommendation;Regimen;Reporting;Resolution;response;scaffold;Schistosoma;Schistosoma mansoni;Schistosomiasis;screening;Sensory;small molecule;Snails;Stimulus;success;Technology;Testing;tool;transmission process;ultra high resolution;Water;Work;World Health Organization

PROJECT_TITLE: Molecular Determinants and Behavioral Fingerprints of Schistosome Miracidia Host-Seeking

STUDY_SECTION: TVZ

STUDY_SECTION_NAME: Transmission of Vector-Borne and Zoonotic Diseases Study Section [TVZ]


NIH_SPENDING_CATS: Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: LAS VEGAS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF NEVADA LAS VEGAS

ORG_STATE: NV

PHR: PROJECT NARRATIVE This project aims to delineate the signaling mechanisms that regulate early processes necessary for the typical development of the cortex. The proposed research has implications for understanding the underlying causes of intellectual disability, which is a core feature of numerous human neurodevelopmental syndromes. This project also supports the inclusive training of undergraduate and graduate students focused on neuroscience and neurodevelopment research at UNLV, which is consistently ranked as one of the nation’s most diverse campuses.

PI_NAMEs: HINES, ROCHELLE MARIE (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Apical;Axon;Binding Proteins;Brain;Butyric Acids;cell cortex;Cell Physiology;Cell Polarity;cell type;Cells;Cellular Morphology;Childhood Neurological Disorder;collybistin;Complex;Data;Dendrites;Development;Developmental Process;Disease;effective intervention;Embryo;Environment;Epilepsy;Fragile X Syndrome;Functional disorder;Funding;Future;gamma-Aminobutyric Acid;Genes;Goals;graduate student;Guanine Nucleotide Exchange Factors;Health;Human;Impairment;In Vitro;in vivo;Inhibitory Synapse;insight;Institution;Intellectual functioning disability;Intervention;Knowledge;Lead;Manuscripts;Mediating;migration;Modeling;Molecular;Morphology;mouse model;Mus;Mutation;neural circuit;neurodevelopment;Neurodevelopmental Disorder;Neurons;Neurosciences;Neurotransmitters;Outcome;Paper;Pathogenesis;Pattern;Phenotype;Play;Positioning Attribute;postnatal;POU Domain;Process;Production;Protein Isoforms;Proteins;Psychiatry;Pyramidal Cells;receptor;reduce symptoms;Regulation;Research;RNA Splicing;Role;Self Efficacy;SH3 Domains;Signal Transduction;Site;Specific qualifier value;stem;STEM career;Study models;success;Symptoms;Synapses;synaptogenesis;Syndrome;Tissues;Training;training opportunity;undergraduate student;Up-Regulation;Vertebral column;virtual;Work

PROJECT_TITLE: Early GABAergic signaling influences axon morphology and cortical cell polarity

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Patient Safety;Precision Medicine;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will older and frail older adults to make informed and individualized decisions regarding treatment for refractory overactive bladder. Thus, the proposed research is relevant to the NIA’s mission to improve our knowledge to develop more effective ways to prevent, diagnose, and treat common diseases and conditions of aging in this underserved and vulnerable population.

PI_NAMEs: SUSKIND, ANNE M. (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Adult;Affect;Age;age group;Aging;aging population;Anxiety;Behavioral;beneficiary;botulinum neurotoxin injection;Calibration;Caring;Caucasians;Characteristics;clinical decision-making;cohort;Dangerousness;Data;Decision Making;Development;Diagnosis;Discrimination;Disease;Elderly;Ethnic Origin;Extravasation;falls;Fee-for-Service Plans;Fracture;Frail Elderly;frailty;Health;health related quality of life;human old age (65+);implantable device;improved;improved outcome;indexing;Individual;ineffective therapies;Injections;innovation;Inpatients;Institutionalization;Knowledge;Measures;medical specialties;Medicare;Mental Depression;middle age;Minor;Mission;neuroregulation;Not Hispanic or Latino;older adult;Older Population;Operative Surgical Procedures;Outcome;Outpatients;Overactive Bladder;Patients;Peripheral;personalized decision;Persons;Pharmacotherapy;Physicians;Population;predictive tools;prevent;primary outcome;Procedures;Process;prognostic tool;prognostication;Provider;Public Health;Quality of life;Race;Refractory;Research;Risk;risk minimization;Selection for Treatments;side effect;Social isolation;Socioeconomic Factors;Socioeconomic Status;socioeconomics;Specialist;stressor;Structure of tibial nerve;Surgeon;Syndrome;System;Testing;Treatment Efficacy;Treatment outcome;Underserved Population;Urine;Variant;Vulnerable Populations;Withholding Treatment;Work

PROJECT_TITLE: Risk determination and prognostication for older and frail older adults undergoing advanced treatments for overactive bladder

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (90)]


ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE – OVERALL Given the continued high prevalence and burden of pain in older people, and the movement away from primary reliance on pharmacological interventions to treat pain, it is crucially important to develop and test treatment alternatives. This proposal seeks to address this need by developing behavioral interventions to mitigate later- life pain with a goal of increasing the health and well being of older adults adversely affected by pain.

PI_NAMEs: REID, MANNEY CARRINGTON (contact);WETHINGTON, ELAINE

PROJECT_TERMS: Achievement;Adaptive Behaviors;Address;Advisory Committees;Affect;alternative treatment;behavior change;Behavior Therapy;behavioral and social science;behavioral clinical trial;Behavioral Mechanisms;Behavioral Sciences;Center for Translational Science Activities;chronic pain management;Clinical Trials;Collaborations;Colorado;commercialization;Development;Disparity;Effectiveness;Elderly;Elements;Ensure;Environment;Exercise Therapy;Fostering;Funding;Funding Agency;Goals;Grant;Health;High Prevalence;hybrid type 2 trial;improved;Industry;Industry Collaboration;industry partner;Informal Social Control;Information Sciences;Infrastructure;innovation;Institute of Medicine (U.S.);Institution;Interdisciplinary Study;Intervention;Intervention Trial;knee replacement arthroplasty;Knowledge;late life;Leadership;Link;Manuscripts;Measurable;Medicine;mHealth;Michigan;Minority Groups;Modeling;Monitor;Movement;new technology;New York City;older adult;Older Population;Operative Surgical Procedures;Pain;Pain management;pain self-management;Patients;Personal Satisfaction;pharmacologic;Population;Program Development;programs;psychologic;Public Health;Publishing;Recommendation;Research;Research Institute;Research Personnel;Resources;Rural;Science;Self Management;Social Processes;social science research;Strategic vision;Structure;success;Technology;telehealth;Testing;therapy development;Translating;Translational Research;Translations;Underrepresented Populations;United States National Institutes of Health;Universities;urban minority

PROJECT_TITLE: Cornell Roybal Center-Translational Research Institute on Pain in Later Life


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Chronic Pain;Pain Research

PI_NAMEs: REID, MANNEY CARRINGTON (contact)

PROJECT_TERMS: Advisory Committees;Affect;aging related;alternative treatment;Behavior Therapy;Behavioral;behavioral and social science;Budgets;Capsicum;career;Center for Translational Science Activities;Characteristics;Clinical Trials;Code;Collaborations;Colorado;commercialization;Committee Members;Communities;cost;Decision Making;Development;Disease;Dissemination and Implementation;Environment;equity, diversity, and inclusion;Evaluation;flexibility;forging;Fostering;Funding;Goals;Health;High Prevalence;improved;Industry;industry partner;Infrastructure;innovation;Interdisciplinary Study;Intervention;Intervention Studies;Investments;Joints;late life;Medicine;member;Methodology;Michigan;Modeling;Movement;older adult;Older Population;Operative Surgical Procedures;organizational structure;outreach;Pain;Pain management;Personal Satisfaction;pharmacologic;program dissemination;programs;Quality of life;Recommendation;Reporting;Research;Research Design;Research Institute;Research Personnel;Resource Allocation;Resources;Science;Scientist;Shapes;skills;social;social interventions;social science research;Source;Strategic vision;Structure;study population;success;Suggestion;System;Testing;therapy design;therapy development;Translational Research;Translations;trend;Underrepresented Populations;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Chronic Pain;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pain Research;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PROJECT_TERMS: Active Learning;Address;Adult;Advisory Committees;Affect;Aging;Agreement;Applications Grants;Area;behavior change;Behavior Therapy;Behavioral;behavioral and social science;Behavioral Mechanisms;Capsicum;career;Center for Translational Science Activities;Childhood;Clinical Trials;Collaborations;collaboratory;Colorado;community living;Consultations;cost;Data;Data Analyses;data management;Development;Discrimination;Dissemination and Implementation;driving behavior;Economics;Education;Effectiveness;Elderly;Elements;Ensure;Environmental Risk Factor;ethnic minority;Exposure to;Extramural Activities;Feedback;Fostering;Funding;Funding Agency;Goals;Grant Review;Health;hybrid type 2 trial;Impaired cognition;improved;Industry;Industry Collaboration;Informal Social Control;Infrastructure;innovation;Institution;Intervention;Investments;knee replacement arthroplasty;late life;Leadership;Measurable;Methodology;Michigan;Minority;Minority Groups;Modeling;Monitor;multidisciplinary;older adult;Operative Surgical Procedures;Pain;Pain management;pain self-management;Patients;Personal Satisfaction;Pilot Projects;Population;Program Development;program dissemination;Psychosocial Factor;racial minority;recruit;Research;Research Activity;Research Design;Research Institute;Research Personnel;Resources;Rural;rural area;Science;Series;skills;Small Business Innovation Research Grant;Social isolation;Social Processes;Stress;success;telehealth;Telephone;Testing;therapy development;tool;translational approach;translational pipeline;translational progress;Translational Research;Underrepresented Populations;United States National Institutes of Health;urban minority;Work


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Pediatric

ORG_CITY: SAN RAFAEL

ORG_NAME: DOMINICAN UNIVERSITY

PHR: Project Narrative This project seeks to understand the genetics behind unique eye morphologies in cave populations of the crustacean Asellus aquaticus. This information will give us a better understanding of the process of eye degeneration by showing whether eye degeneration is linked to other morphologies and by mapping regions responsible for naturally occurring variation in eye size in multiple eyeless lineages.

PI_NAMEs: PROTAS, MEREDITH E (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Adaptive Behaviors;Address;Affect;Alleles;Animals;Anophthalmos;base;Behavior;Biological Models;Candidate Disease Gene;causal variant;Characteristics;Chemotaxis;Chromosome Mapping;comparative;Congenital Disorders;Coupled;Crustacea;Data;Defect;Development;dietary restriction;differential expression;Disease;disease model;DNA Sequence Alteration;DNA sequencing;Drosophila genus;Drosophila melanogaster;Embryo;Eye;Eye Abnormalities;Eye Development;eye formation;fly;Gene Expression;Genes;Genetic;genetic manipulation;Genetic study;genetic variant;Geography;Goals;Grant;Human;Hybrids;Individual;interest;Invertebrates;Length;life span;Link;Literature;Maps;Methods;Microphthalmos;Modeling;Morphology;Mus;mutant;novel;novel strategies;offspring;Organism;overexpression;Pathway interactions;patient subsets;Phenotype;Phylogenetic Analysis;Population;Process;Regenerative capacity;Romania;Sampling;Sensory;Site;Slovenia;Structure;Study models;Surface;Syndrome;transcriptome;transcriptome sequencing;transcriptomics;Variant;Work

PROJECT_TITLE: Genetic and functional analysis of eye degeneration in natural populations of a cave-dwelling crustacean

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-C (81)]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Neurosciences;Pediatric;Prevention;Rare Diseases;Rehabilitation;Rural Health;Social Determinants of Health;Vector-Borne Diseases

ORG_CITY: GREENVILLE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: EAST CAROLINA UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative This project focuses on the socioeconomic impact of neuroinvasive/non-neuroinvasive La Crosse virus disease (most common cause of arboviral pediatric encephalitis in the United States) in western North Carolina. Economic wellbeing may contribute to disparities in risk awareness, adherence to personal protection, and clinical recognition and this relationship will be verified, along with site assessments of mosquito-related risks. Findings are expected to contribute to the development of public/environmental health strategies to intervene to improve risk reduction, treatment, and recovery resources, thereby reducing impact on survivors and families.

PI_NAMEs: BYRD, BRIAN DAVID;RICHARDS, STEPHANIE LYNN (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: 16 year old;Absenteeism at work;Academic support;Acute;Adherence;Aedes;Age;Appalachian Region;Arboviruses;Area;Attitude;Awareness;Behavior;Biology;Caregivers;Case Study;Child;Childhood;Chronic;Classification;Clinic;Clinical;Clinical assessments;Cognitive;cohort;Collection;Communities;Community Health Education;County;Culicidae;Development;Developmental Delay Disorders;Disease;Disparity;Distress;Economic Burden;economic cost;economic impact;Economics;Education;Encephalitis;Enrollment;Environmental Health;Environmental Risk Factor;Evaluation;experience;Facilities and Administrative Costs;Family;Family member;follow-up;graduate student;Health;Health Benefit;Health protection;Healthcare;Home;Hospitals;Household;improved;Incidence;Infection;instrument;Intervention;Interview;Knowledge;La Crosse encephalitis;La Crosse virus;Laboratories;land cover;low socioeconomic status;Measures;Medical;Meningitis;Mental Health;mental health counseling;Methods;Mission;Morbidity - disease rate;mortality;Mosquito Control;Neighborhoods;Neurologic Dysfunctions;North Carolina;Occupational Therapy;Orthobunyavirus;Outcome;Oviposition;Participant;Patients;Perception;Personal Satisfaction;Persons;Pharmaceutical Preparations;Positioning Attribute;Prevention;Property;public education;Public Health;public health priorities;Recommendation;Recovery;Research;residence;Resources;Risk;Risk Assessment;Risk Reduction;rural area;rural counties;rural setting;screening;Severities;Severity of illness;Site;social;socioeconomics;Survey Methodology;Surveys;Survivors;Testing;Time;transmission process;Travel;tutoring;undergraduate student;underserved area;United States;vector;vector mosquito;virtual;Virus Diseases

PROJECT_TITLE: Socioeconomic impacts of La Crosse encephalitis in western North Carolina

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


ORG_DEPT: NEUROLOGY

PHR: Narrative: Overall The increasing aging population is accompanied by a comparable increase in those who will suffer cognitive impairment, which impacts quality of life for the individual, and at scale, impacts every sector of society. Therefore, maintaining or improving cognition in aged adults at risk of dementia, even for a few months, could have an important effect at the population level. To achieve this, the Roybal Center will conduct Stage 0 through V pilot studies in accordance with the multidirectional, translational NIH Stage Model, to produce potent and implementable principle-driven behavioral interventions.

PI_NAMEs: GAZZALEY, ADAM H (contact);WAIS, PETER EDWARD;ZANTO, THEODORE P

PROGRAM_OFFICER_NAME: TREVINO, MELISSA

PROJECT_TERMS: Adult;Advisory Committees;Age-associated memory impairment;aged;aging population;Alzheimer's disease related dementia;Alzheimer's disease risk;arm;attentional control;Behavior Therapy;Behavioral;Center for Translational Science Activities;Clinical Trials;Cognition;Cognitive;cognitive function;Collaborations;Communication;Communities;community setting;Complex;Conduct Clinical Trials;Data;Dementia;dementia risk;design;Development;digital intervention;Effectiveness;efficacy evaluation;Elderly;experience;Funding;Future;Grant;Home;Impaired cognition;Impairment;improved;Individual;Infrastructure;interest;Intervention;intervention refinement;Leadership;meetings;Memory;Methods;Modeling;Modernization;Monitor;next generation;older adult;Outcome Assessment;Participant;Persons;Pilot Projects;Play;Population;prevent;programs;Progress Reports;Quality of life;Randomized;remote intervention;remote screening;Research;Research Personnel;research study;Science;Societies;Strategic vision;synergism;Tablets;Technology;therapy development;Translations;trial design;United States National Institutes of Health;virtual assessment;virtual reality;virtual reality intervention;web platform;Work

PROJECT_TITLE: Closed-loop digital interventions through a remote clinical trials platform.


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: GAZZALEY, ADAM H (contact)

PROJECT_TERMS: active duty;Advisory Committees;Age;Alzheimer's disease related dementia;Alzheimer's disease risk;artist;Behavior Therapy;Clinical Trials;cognitive function;Collaborations;Communication;Communities;community center;Complex;Computer software;computerized;Computers;Data;Data Scientist;design;Development;digital intervention;Effectiveness;efficacy evaluation;Ensure;experience;feasibility testing;Fostering;Funding;Goals;Grant;Impaired cognition;Industry;Infrastructure;Institution;interest;Intervention;Knowledge;Leadership;meetings;Memory;Methodology;Mission;Modeling;Monitor;Multi-Institutional Clinical Trial;older adult;Postdoctoral Fellow;prevent;Process;programs;Progress Reports;Publishing;Reporting;Research;Research Personnel;research study;Role;Science;Site;Strategic vision;synergism;System;Technology;Testing;therapy development;translational neuroscience;Translations;United States National Institutes of Health;Validation;Video Games;web site;Work


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Neurodegenerative;Neurosciences;Prevention;Rehabilitation

PI_NAMEs: ZANTO, THEODORE P (contact)

PROJECT_TERMS: Academia;aged;Alzheimer's disease related dementia;Alzheimer's disease risk;arm;Attention;Attention deficit hyperactivity disorder;Behavior Therapy;Behavioral Model;Brain;Child;Clinical Trials;Cognitive;cognitive function;cognitive performance;cognitive testing;cognitive training;Collaborations;community setting;Dementia;design;digital intervention;Educational Intervention;Effectiveness;effectiveness study;efficacy evaluation;efficacy study;Elderly;FDA approved;feasibility testing;Feedback;Future;Goals;Home;Impaired cognition;Impairment;improved;insight;Intervention;intervention refinement;Labyrinth;long term memory;Memory;Methods;mild cognitive impairment;Modeling;Modernization;Nature;new technology;next generation;Nonpharmacologic Therapy;older adult;Outcome Assessment;Participant;Patients;Persons;Phase;Play;Population;predictive modeling;prevent;Private Sector;progression risk;Randomized;remote screening;Research;Role;Route;Short-Term Memory;Tablets;Technology;Testing;therapy development;trial design;United States National Institutes of Health;Veins;Video Games;virtual assessment;virtual reality;virtual reality intervention;Vision;web platform;Work


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Data Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Rural Health;Social Determinants of Health

ORG_CITY: TUSKEGEE INSTITUTE

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: TUSKEGEE UNIVERSITY

ORG_STATE: AL

PHR: PROJECT NARRATIVE  Carver Genomic Research Center, Diversity Centers for Genome Research, is an initiative at TU to establish a genomic health program focused on disparity research. The program aims to promote inclusivity in genomic research, education, and workforce development.

PI_NAMEs: BEDI, DEEPA  (contact)

PROGRAM_OFFICER_NAME: RIVERS, ROBERT C

PROJECT_TERMS: Academia;Address;Affect;African American population;African Women;Alabama;Area;Artificial Intelligence;Attention;Awareness;biobank;Bioethics;Bioinformatics;Biomedical Research;Black race;Bladder Carcinoma;Cancer Patient;cancer risk;career development;Characteristics;Classification;Collaborations;Communities;Community Developments;community engagement;community involvement;Community Outreach;Community Participation;Core Facility;County;Data Analytics;Data Scientist;Dedications;deep learning;Development;Dimensions;Disease;Disparity;disparity gap;Education;Educational process of instructing;Educational workshop;empowerment;Epigenetic Process;Equipment;Ethnic Origin;Evaluation;Faculty;Fostering;Foundations;Friends;Funding;Genetic;Genome;genome sciences;genomic data;Genomics;Goals;Government;Health;health disparity;health inequalities;Heart;Histologic;Histology;Industry;Infrastructure;innovation;instrumentation;interdisciplinary collaboration;learning network;Machine Learning;meetings;member;Mentors;metabolomics;Minority;Minority Groups;Minority-Serving Institution;Mission;Modernization;Morphology;Names;neural network;Neural Network Simulation;next generation;operation;Outcome Assessment;outreach services;Participant;Pattern;Phase;Phenotype;Play;Population;potential biomarker;Process;programs;Proteomics;recruit;Request for Applications;Research;Research Activity;Research Design;Research Personnel;Research Project Grants;Role;Rural;Schedule;Scientific Advances and Accomplishments;Scientist;Services;Solid;Structure;Suggestion;symposium;targeted treatment;Tissue Sample;Training;Training Programs;transcriptomics;Transitional Cell Carcinoma;triple-negative invasive breast carcinoma;tumor;undergraduate student;Underserved Population;Universities;Vision;Workforce Development;Xenobiotics

PROJECT_TITLE: Carver Genomic Research Center (CGRC)-Building Next Generation Genomic Data Scientist in Rural Alabama

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-P (J1)]


ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Narrative The USC-Yale Roybal Center for Behavioral Interventions in Aging aims to improve the general effectiveness of behavioral interventions that address over- and underused health services in aging populations by clarifying their mechanisms of behavior change. The Center will support a Behavioral Interventions Development Core for research and an Administrative Core that oversees all Center activities. The Center will sustain and grow the community of researchers conducting mechanism of behavior change research to encourage appropriate use of medical treatments that affect people aging through the lifespan.

PI_NAMEs: DOCTOR, JASON N. (contact);MEEKER, DANIELLA

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Address;Advance Care Planning;adverse outcome;Advisory Committees;Affect;Aging;Award;Basic Science;Beds;Behavior;behavior change;Behavior Therapy;Behavioral;behavioral economics;Behavioral Mechanisms;Behavioral Model;Behavioral Sciences;Caring;Communities;community setting;Development;effective intervention;Effectiveness;Elderly;Emergency department visit;Ensure;Equity;Evidence Based Medicine;Experimental Designs;Follow-Up Studies;Funding;Goals;Grant;Health Care Costs;Health Services;Health system;Healthcare;improved;Individual;Institution;Intervention;Intervention Studies;life span;Mediator;Medical;member;middle age;Modeling;older adult;online resource;Outcome;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Physicians;Population;population health;Process;Provider;Proxy;psychologic;Randomized;randomized trial;Recommendation;Request for Applications;Research;Research Personnel;Resources;Scientist;Site;Statistical Computing;Testing;therapy design;therapy development;Translating;Translations;United States National Institutes of Health;uptake;Vision;Work


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Services;Prevention

PHR: PER RFA, NO NARRATIVE NEEDED FOR COMPONENT ON MULTI PROJECT SUBMISSION.

PI_NAMEs: DOCTOR, JASON N. (contact)

PROJECT_TERMS: Address;Adult;adverse outcome;Advisory Committees;Aging;Award;behavior change;Behavior Therapy;Behavioral;Behavioral Mechanisms;Behavioral Model;Behavioral Research;care delivery;care outcomes;Caring;Characteristics;Clinical;Clinical Research;Clinical Trials;Code;Cognitive;Collaborations;Communities;Data;data management;data sharing;Effectiveness;Enrollment;Ensure;Environment;Evaluation;Fostering;Funding;Goals;Grant;Health Care Costs;Health system;Healthcare;improved;interest;Intervention;Intervention Studies;Knowledge;Medical;meetings;member;Modeling;Monitor;Monitoring Clinical Trials;National Institute on Aging;Operations Research;Outcome;Pathway interactions;patient population;Patients;Personal Satisfaction;Play;Population;population health;Principal Investigator;Process;Program Evaluation;programs;Progress Reports;Provider;provider behavior;Recommendation;Request for Applications;Research;Research Design;Research Methodology;Research Personnel;Resources;Role;Science;Scientific Advances and Accomplishments;Scientist;Services;social;Statistical Computing;System;therapy development;Training;Translational Research;Travel;United States National Institutes of Health;uptake;Work;Writing

PROJECT_TITLE: USC-Yale Roybal Center for Behavioral Interventions in Aging


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Prevention;Primary Health Care

PROJECT_TERMS: Address;Adoption;Adult;advanced directive;Advisory Committees;Aging;Appointment;behavior change;behavior test;Behavior Therapy;Behavioral Mechanisms;Behavioral Model;Behavioral Sciences;Caring;Clinical Trials;Cluster randomized trial;community setting;compare effectiveness;design;Drug Prescriptions;effective intervention;Effectiveness of Interventions;efficacy evaluation;efficacy testing;Ensure;Evolution;Feedback;Funding;Goals;Health;health care delivery;Health Services;Health system;Healthcare;implementation science;improved;Infrastructure;innovation;Institution;Intervention;Life Cycle Stages;Mediating;medication safety;Methodology;Modeling;Modification;Outcome;Patients;peer;Personal Satisfaction;Pharmaceutical Preparations;Play;Population;Primary Care;primary care provider;Process;programs;Proxy;randomized trial;real world application;Request for Applications;Research;research and development;Research Project Grants;Research Support;Role;Scientific Advances and Accomplishments;Series;Services;social norm;System;Testing;therapy development;Translations;treatment as usual;United States National Institutes of Health;Update;uptake


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_DEPT: OPHTHALMOLOGY

PHR: 8. Project Narrative The Department of Ophthalmology and Visual Sciences at the University of Illinois at Chicago (UIC) is proposing to continue their K12 independent clinical vision scientist career development program. This program which has been successful in the past 12 years, aims to provide an academically-rich and supportive environment for early -stage clinicians in a mentored learning experience that facilitates their career advancement in becoming independent vision scientists. By training clinician- vision scientists who will engage in cutting edge eye research, this program will contribute to the improvement of eye health for the society.

PI_NAMEs: DJALILIAN, ALI R (contact);JOSLIN, CHARLOTTE E

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Bioinformatics;career;career development;Caring;Chicago;Clinical;didactic education;Doctor of Medicine;Doctor of Veterinary Medicine;Educational Curriculum;Experimental Designs;Eye;Faculty;Fostering;fundamental research;Funding;Generations;Goals;Grant;Health;Illinois;improved;Institution;Knowledge;Mentored Clinical Scientist Development Program;Mentors;Midwestern United States;novel;Ophthalmology;Peer Review;personalized medicine;Policies;Population Research;Professional Competence;Program Development;programs;Publications;Quality of life;recruit;Reproducibility;Research;Research Personnel;responsible research conduct;Science;Scientist;Strategic Planning;success;tool;Training;translational potential;Underrepresented Minority;United States National Institutes of Health;Universities;Vision;Woman

PROJECT_TITLE: UIC K12 independent Clinical Vision Scientist Development Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (05)]


ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Most adults will experience serious health events in their lifetime, and these events will commonly result in psychological distress that impacts on quality of life and health behaviors that are needed to promote recovery and prevent recurrent events. Our Columbia Roybal Center for Fearless Behavior Change will advance mechanism-driven interventions that target psychological distress and assess whether better health behaviors result. Our existing research infrastructure inclusive of a common measures repository for mechanisms assessment, a standardized electronic assessment suite for behavior, implementation science expertise, and strong collaborations with patient stakeholders and scientific experts in the experimental medicine approach to behavioral intervention development will ensure that the trials conducted in our Center are well-positioned to yield impactful interventions.

PI_NAMEs: KRONISH, IAN MATTHEW (contact);MOISE, NATHALIE

PROJECT_TERMS: Acceleration;Address;Adoption;Adult;Anxiety;Area;Behavior;behavior change;behavior measurement;behavior test;Behavior Therapy;Behavioral;Behavioral Mechanisms;Behavioral trial;cancer diagnosis;Cardiac;Cardiovascular Diseases;Caregivers;clinical practice;Clinical Trials;Cluster randomized trial;Collaborations;Communities;Conduct Clinical Trials;Critical Illness;Data;depressed patient;depressive symptoms;Development;digital;Disease Progression;disorder risk;Distress;effective intervention;efficacy testing;Electronics;Ensure;Event;evidence base;Evidence based intervention;Evidence based treatment;Exercise;experience;Experimental Models;feasibility testing;Fostering;Fright;Funding;Goals;Health;Health behavior;health inequalities;Health system;Heart Arrest;Heart Rate;implementation framework;implementation research;implementation science;implementation strategy;improved;Infrastructure;interest;Intervention;Life;Measurement;Measures;Medical;Medicine;Mental Depression;middle age;mindfulness;Modeling;multidisciplinary;Myocardial Infarction;next generation;older adult;Outcome;participant enrollment;Patients;Personal Satisfaction;Pharmaceutical Preparations;Physical activity;Physiological;Positioning Attribute;Post-Traumatic Stress Disorders;prevent;Productivity;Prognosis;Program Development;programs;psychologic;psychological distress;Quality of life;randomized, clinical trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Recommendation;Recovery;Recurrence;repository;Research;Research Infrastructure;Research Priority;research study;response;Risk Reduction;role model;Science;Scientist;Sleep;Speed;standard of care;Standardization;Stress;Stroke;Survivors;Symptoms;Testing;therapy development;tool;Training;Trauma;treatment as usual;United States National Institutes of Health;uptake

PROJECT_TITLE: Columbia Roybal Center for Fearless Behavior Change - Renewal


NIH_SPENDING_CATS: Aging;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Cardiovascular;Depression;Dissemination and Implementation Research;Heart Disease;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Prevention

PI_NAMEs: KRONISH, IAN MATTHEW (contact)

PROJECT_TERMS: Acceleration;Adoption;Adult;Advisory Committees;Anxiety;Award;behavior change;behavior measurement;Behavior Therapy;Behavioral Mechanisms;Behavioral Medicine;Behavioral trial;cancer diagnosis;Charge;Clinical Trials;Collaborations;Committee Members;Communication;Communities;Conduct Clinical Trials;Critical Illness;depressive symptoms;Disease Progression;disorder risk;Distress;effective intervention;Ensure;equity, diversity, and inclusion;Evaluation;Event;Evidence based intervention;Exercise;experience;Feedback;Fright;Goals;Grant;Health;Health behavior;Health Promotion;Heart Arrest;Heart Rate;Hour;Human Resources;implementation research;implementation science;improved;Institutional Review Boards;interest;Intervention;Leadership;Life;Maintenance;Manuscripts;Measurement;Measures;Medicine;meetings;member;Mental Depression;Mentors;Methodology;middle age;Modeling;Monitor;Multimedia;Myocardial Infarction;National Institute on Aging;Office of Administrative Management;older adult;operation;Participant;participant retention;Patients;Personal Satisfaction;Pharmaceutical Preparations;Physiological;Policies;Post-Traumatic Stress Disorders;Press Releases;prevent;Process;Prognosis;programs;prospective;psychological distress;Quality of life;Recommendation;recruit;Recurrence;Regulation;repository;Research;Research Activity;Research Personnel;Resources;Science;Scientist;searchable database;Series;Sleep;Strategic vision;Stress;Stroke;study characteristics;success;Symptoms;Testing;therapy development;Training;United States National Institutes of Health;Universities;Vision;web site;Work

PROJECT_TITLE: Roybal Center for Fearless Behavior Change - renewal  Administrative Core


NIH_SPENDING_CATS: Aging;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Depression;Dissemination and Implementation Research;Heart Disease;Mental Health;Mental Illness;Physical Activity;Post-Traumatic Stress Disorder (PTSD);Prevention

PI_NAMEs: MOISE, NATHALIE  (contact)

PROJECT_TERMS: Acceleration;Adoption;Adult;Aftercare;Aging;Anxiety;behavior change;behavior measurement;Behavior Therapy;Behavioral;Behavioral Mechanisms;Benchmarking;cancer diagnosis;Cardiac;Cardiovascular Diseases;Clinical;Clinical Trials;Cluster randomized trial;Collaborations;Conduct Clinical Trials;Critical Illness;Data Analyses;data management;Depressed mood;depressed patient;depressive symptoms;Development;Diagnosis;digital;Disease Progression;disorder risk;Distress;effective intervention;efficacy testing;Ensure;Event;evidence base;Evidence based intervention;Evidence based treatment;Exercise;experience;feasibility testing;follow-up;Fright;Goals;Health;Health behavior;Health Promotion;Heart Arrest;Heart Rate;implementation outcomes;implementation research;implementation science;implementation strategy;improved;Infrastructure;interest;Intervention;Life;Maintenance;Malignant Neoplasms;Measurement;Mediating;medication compliance;Mental Depression;middle age;mindfulness;Modeling;Myocardial Infarction;next generation;older adult;Outcome;patient engagement;patient oriented;Patients;Personal Satisfaction;Pharmaceutical Preparations;Physical activity;Physiological;pilot test;Post-Traumatic Stress Disorders;prevent;primary outcome;Prognosis;programs;psychologic;psychological distress;Quality of life;randomized, clinical trials;Readiness;Recommendation;Recovery;Recurrence;Research;Science;Secondary Prevention;Sleep;standard of care;Standardization;Stimulus;Strategic vision;Stress;Stroke;Survivors;Symptoms;Testing;theories;therapy development;tool;treatment as usual;United States National Institutes of Health;uptake

PROJECT_TITLE: Roybal Center for Fearless Behavior Change - renewal  Behavioral Intervention Development (BID) Core


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Depression;Mental Health;Prevention

ORG_CITY: TUSCALOOSA

ORG_NAME: UNIVERSITY OF ALABAMA IN TUSCALOOSA

PHR: PROJECT NARRATIVE  Teachers are at notable risk for depression and anxiety. The present study tests an app-based mindfulness intervention for teachers in their final year of training with the goal of preventing the deterioration of their mental health during the transition into the classroom. The project will strengthen the research environment at the University of Alabama and will involve undergraduate research assistants in each step of the research process.

PI_NAMEs: BRAUN, SUMMER  (contact)

PROGRAM_OFFICER_NAME: ROONEY, MARY

PROJECT_TERMS: acceptability and feasibility;Address;Alabama;Anxiety;anxiety symptoms;Awareness;Businesses;Clinical;Cognitive;Data;depressive symptoms;Deterioration;Diagnosis;dosage;Education;Educational process of instructing;effectiveness trial;Environment;experience;feasibility testing;Focus Groups;Future Teacher;General Population;Goals;Historically Black Colleges and Universities;Hybrids;improved;Individual;innovation;inservice teacher;insight;instructor;Intervention;Logic;marginalized population;Measures;Mental Depression;Mental Health;mHealth;mhealth interventions;Mind;mindfulness;mindfulness intervention;Modeling;Outcome;outcome prediction;pandemic disease;Participant;Patient Self-Report;Peer Review;Perception;Personal Satisfaction;Population;post intervention;prevent;Process;Program Acceptability;programs;Publications;Randomized, Controlled Trials;Regression Analysis;Reporting;Research;Research Assistant;Resources;Risk;Sampling;scale up;secondary outcome;Services;skills;smartphone application;Stress;Structure;Suggestion;symposium;teacher;Teacher Professional Development;Testing;theories;Time;Training;Training Programs;undergraduate research;undergraduate research experience;undergraduate student;Universities;university student

PROJECT_TITLE: A Pilot Effectiveness Trial of an Adapted App-Based Mindfulness Intervention for Pre-Service Teachers

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative-Overall  The primary objective of the Establishing Mechanisms of Benefit to Reinforce the Alzheimer’s Care Experience AD/ADRD Roybal Center (EMBRACE) is to provide scientific infrastructure to support the testing of mechanisms in tailored home and community dementia care intervention trials across Stages 0-V of the NIH Stage Model. The Aims of EMBRACE are as follows: 1) Leverage the extensive expertise of EMBRACE to attract and support early stage to expert Investigators to test mechanistically driven dementia care interventions across the NIH Stage Model; 2) Advance the science of testing mechanisms of tailored dementia care interventions in home and community settings; and 3) Conduct a robust evaluation of EMBRACE to ensure appropriate progress of supported trials.

PI_NAMEs: GAUGLER, JOSEPH E. (contact);GILMORE-BYKOVSKYI, ANDREA L

PROJECT_TERMS: Address;Adopted;advanced dementia;Alzheimer's Disease;Alzheimer's disease care;Alzheimer's disease related dementia;Award;Basic Science;Behavior Therapy;Caring;Clinical;Clinical Trials;Collaborations;collaboratory;Communities;community organizations;community setting;Consultations;dementia care;Development;Dissemination and Implementation;education resources;Effectiveness;Ensure;Evaluation;Evidence based intervention;experience;Faculty;Family;Funding;Generations;Healthcare;Healthcare Systems;Home;implementation efforts;Individual;Infrastructure;innovation;Institution;Intervention;Intervention Trial;Investments;Knowledge;Language;Length;Life Cycle Stages;Measurement;Measures;Methodology;Minnesota;Modeling;Modification;Monitor;National Institute on Aging;Outcome;Persons;pragmatic trial;preference;Principal Investigator;programs;Publications;Research Infrastructure;Research Personnel;Resources;Science;Testing;therapy development;Translations;United States National Institutes of Health;Universities;webinar;Wisconsin;Work

PROJECT_TITLE: Establishing Mechanisms of Benefit to Reinforce the Alzheimer's Care Experience AD/ADRD Roybal Center: EMBRACE


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: GAUGLER, JOSEPH E. (contact)

PROJECT_TERMS: Acceleration;Address;Adherence;Advanced Development;Advisory Committees;Alzheimer's Disease;Alzheimer's disease care;Alzheimer's disease related dementia;Area;Assisted Living Facilities;Award;Behavior Therapy;Budgets;Caregivers;caregiving;Caring;Collaborations;Communities;community engagement;Community of Practice;community setting;Complex;Consultations;dementia care;Development;Educational workshop;effective intervention;Ensure;Environment;Evaluation;experience;Funding;Goals;Guidelines;health care settings;Heterogeneity;Home;Human Subject Research;Individual;Infrastructure;Institution;Intervention;Intervention Trial;Leadership;meetings;Mission;Modeling;Monitor;Monitoring Clinical Trials;next generation;Nursing Homes;operation;Persons;Process;Productivity;programs;public health priorities;recruit;Regulation;Reproduction;Research;research and development;Research Infrastructure;Research Personnel;Resources;Schedule;Science;Scientist;Skilled Nursing Facilities;Structure;synergism;Testing;therapy development;Travel;United States National Institutes of Health


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Prevention

PROJECT_TERMS: Adult;Alzheimer's disease care;Alzheimer's disease related dementia;Award;Behavior Therapy;Behavioral;Behavioral Symptoms;Black race;Caregivers;caregiving;Caring;Clinical;Clinical Trials;Cognitive;Collaborations;Communities;community engagement;community setting;Consultations;Dementia;dementia care;Development;Dissemination and Implementation;Educational workshop;empowerment;Ensure;Evidence based program;experience;Faculty;Family;Future;Goals;Guidelines;Hispanic;Home;Immigrant;improved;Individual;interest;Intervention;Intervention Community Trial;Intervention Trial;intrinsic motivation;Lead;Letters;Measures;Mediating;meetings;Mentors;Mentorship;Methodology;Modeling;Monitor;Outcome;Personal Satisfaction;Persons;Policies;Population Heterogeneity;Positioning Attribute;Problem Solving;Process;programs;Provider;Regulation;Research;Research Infrastructure;Research Personnel;Resources;Sampling;Science;Scientist;Services;skills;social;statistics;success;symposium;Testing;therapy development;Training;United States National Institutes of Health;webinar


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences

ORG_CITY: MELBOURNE

ORG_NAME: FLORIDA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Diagnosis and treatment for neurodegenerative diseases remain insufficient to halt disease progression and improve patient outcomes. In order to find new drug targets and biomarkers, it will be important to identify the genetic pathways, molecular and cellular mechanisms underlying degeneration. We propose to use a genetic approach to identify the signaling network functioning downstream of Tau.

PI_NAMEs: BORGEN, MELISSA  (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Academic Research Enhancement Awards;Address;Affect;Alleles;American;Amyloid beta-Protein;Animal Model;Animals;Antibody Therapy;Area;Axon;axon injury;axonal degeneration;Binding;Biological Markers;biomarker identification;Biomedical Research;Caenorhabditis elegans;Cessation of life;Data;Dementia;density;Development;Diagnosis;Diagnostic;Disease;disease model;Disease Progression;drug development;Drug Targeting;Early Diagnosis;Event;Face;Florida;fluorescence imaging;Future;Genes;Genetic;genetic analysis;genetic approach;Growth Cones;Human;improved;in vivo;ineffective therapies;Injury;innovation;insight;interest;Label;Life;life span;Link;Literature;Maintenance;Microtubules;Mitochondria;Modeling;Molecular;Molecular Biology;Morphology;mouse model;Mutation;Nerve Degeneration;nervous system development;Neurodegenerative Disorders;neurodegenerative phenotype;neurodevelopment;neuron loss;Neurons;Neurosciences Research;new therapeutic target;novel;Optics;Orthologous Gene;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Play;Process;Prognosis;protein aggregation;Proteins;Publishing;Regulation;Research;Research Infrastructure;Role;Severities;Signal Pathway;Signal Transduction;Students;Symptoms;Synapses;synaptogenesis;targeted treatment;tau Proteins;tau-1;Tauopathies;Technology;therapy outcome;Time;timeline;Transgenic Organisms;ubiquitin-protein ligase;Ubiquitination;undergraduate student;Work

PROJECT_TITLE: The role of PHR signaling in tauopathy-related neurodegeneration

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: OXFORD

ORG_NAME: MIAMI UNIVERSITY OXFORD

ORG_STATE: OH

PHR: Project Narrative The positive emotional affects of opioid use and negative emotional effects of withdrawal contribute to the development of Opioid Use Disorder, which accounts for tens of thousands of deaths in the United States each year. This project will use mouse models of morphine reward, fentanyl consumption, and naloxone-precipitated withdrawal to investigate how mu-opioid receptors on a subpopulation of neurons in the nucleus accumbens promote opioid reward and aversion. Understanding the neural mechanisms responsible for Opioid Use Disorder will inform future therapies and treatments for the disease.

PI_NAMEs: RADKE, ANNA KAY (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Acetylcholine;Address;Affect;Area;Behavior;Behavioral;Behavioral Model;Binding;Biomedical Research;Brain;Breeding;Cells;Cessation of life;Characteristics;cholinergic;cholinergic neuron;conditioned place preference;Consumption;Corpus striatum structure;Cues;Data;Development;Disease;Dopamine;dopaminergic neuron;drinking;Emotional;Equipment;experience;experimental study;Fentanyl;Fluorescent in Situ Hybridization;Fluorophotometry;Future;Genes;Genetic;Health Care Costs;in vivo;innovation;interest;Interneurons;knock-down;Laboratories;Mentors;Methods;Midbrain structure;Modernization;Monitor;Morphine;morphine administration;Motivation;mouse model;mu opioid receptors;Naloxone;negative emotional state;neurochemistry;neuromechanism;Neurons;Neurosciences;Neurosciences Research;Nucleus Accumbens;Opioid;opioid use;opioid use disorder;opioid withdrawal;Pattern;Population;Population Heterogeneity;pre-clinical;Public Health;recruit;Regulation;Research;Resources;Rewards;Role;sensor;Signs and Symptoms;Source;Students;success;Symptoms;Synapses;System;Talents;Techniques;Technology;Testing;therapeutic target;Training;Transgenic Mice;undergraduate research;undergraduate student;United States;Universities;Ventral Tegmental Area;Viral;Viral Vector;Withdrawal;Work

PROJECT_TITLE: Cholinergic interneuron regulation of opioid-related behaviors

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Genetics;Multiple Sclerosis;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ATHENS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: PROJECT NARRATIVE Lack of remyelination results in axonal degeneration and debilitating clinical outcomes in demyelinating diseases like Multiple Sclerosis. Here, we propose to determine how TGFβ1 signaling regulates remyelination through Gpnmb, a novel modulator of the pathway, expressed highly in response to demyelination in neural stem cells. These studies will help to determine new strategies for promoting remyelination in the diseased human brain.

PI_NAMEs: SAMANTA, JAYSHREE  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Ablation;Adult;axonal degeneration;Binding Sites;Bioinformatics;Brain;CD44 gene;Cell Culture Techniques;cell type;Cells;Choline;Chronic;Clinical;Corpus Callosum;Cuprizone;Data;Demyelinating Diseases;Demyelinations;Diet;differential expression;Disease;dosage;Exhibits;extracellular;Gene Expression;Genes;glycoprotein NMB;Glycoproteins;Human;human disease;In Vitro;in vivo;Injections;insight;Knock-out;Knockout Mice;Lesion;Ligands;LoxP-flanked allele;Mediating;Mediator;Melanoma;Modeling;Molecular;Multiple Sclerosis;multiple sclerosis patient;Mus;Nerve Degeneration;nerve stem cell;Nonmetastatic;novel;Oligodendroglia;Outcome;overexpression;paracrine;Pathway interactions;peripheral blood;Population Heterogeneity;prevent;Promoter Regions;receptor;receptor binding;Recovery of Function;recruit;Regulation;remyelination;repaired;Reporting;response;Role;Signal Pathway;Signal Transduction;Source;subventricular zone;Testing;therapeutic target;Toxin;transcription factor;transcriptome sequencing;transcriptomics;Transforming Growth Factor beta;Work

PROJECT_TITLE: Novel Modulators of TGFß1 signaling in regulation of remyelination by neural stem cells


ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: PROJECT NARRATIVE Aging is the number one risk factor associated with disease in the United States. Although we take this granted, genetic discoveries over the last few decades suggest that it is possible to directly intervene on the aging process itself, to date it has been very difficult to look for new mutations affecting aging and longevity because individuals at extreme old age tend to be past the ability to reproduce, even in model organisms. This work aims to expand new genome editing technology to rapidly produce and identify mutations that enhance longevity in post-reproductive individuals, setting the stage for future development of drugs and other interventions aimed at extending health aging in all people.

PI_NAMEs: PHILLIPS, PATRICK C. (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Adult;Affect;Age;age related;Aging;aging process;Animal Model;animal old age;Animals;Bar Codes;behavioral phenotyping;C. elegans genome;Caenorhabditis elegans;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;comparative;Compensation;Detection;Development;Disease;drug development;Eating;Elements;Family;Future;Gene Library;Gene Transfer Techniques;Genes;Genetic;genetic approach;Genetic Crosses;Genetic Screening;Genetic Transformation;Genome;genome editing;Genome engineering;genome sequencing;genome wide screen;Genomic Library;genomic locus;Germ-Line Mutation;Goals;Grant;Guide RNA;Health;healthy aging;Heritability;Hermaphroditism;Human;human old age (65+);Individual;Infertility;Intervention;Knock-out;Libraries;Life;life span;Location;Longevity;longevity gene;Maps;Methods;microbial;model organism;Modeling;Molecular Target;Mutagenesis;mutant;Mutation;Mutation Analysis;mutation screening;Nematoda;Noise;novel;novel strategies;Outcome;Partner in relationship;Persons;Phenotype;Population;Reporter;Reproducibility;Reproduction;reproductive;reproductive longevity;Research;Research Project Grants;Risk Factors;screening;Signal Transduction;Site;Somatic Mutation;Standardization;success;System;Technology;Testing;Time;trait;Transgenic Organisms;United States;whole genome;Work

PROJECT_TITLE: Genome engineering for a novel post-reproductive genetic screen for increased longevity

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding;Neurodegenerative

ORG_CITY: MUNCIE

ORG_NAME: BALL STATE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Oxidative stress is a convergent endpoint for a number of human diseases and conditions such as cancer, aging, and neurodegeneration. The roles of sulfur-containing molecules that make up the thiolome are emerging as a mechanism for cells to counteract the deleterious impact of oxidative stress. This study investigates the role(s) of mitoNEET’s enzymatic activity on maintaining the cellular thiolome in order to combat oxidative stress found in so many human diseases.

PI_NAMEs: KONKLE, MARY  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Aging;alpha ketoglutarate;assault;beta-mercaptopyruvate;Biochemical;Biochemistry;Biological;Biological Process;cell killing;Cell Physiology;Cells;cellular pathology;Coenzymes;combat;Communities;Consumption;Cysteine;Cystine;Cytosol;Disease;drug discovery;Drug Targeting;druggable target;Electronics;Enzymatic Biochemistry;Enzymes;Equilibrium;Event;experience;Glutamates;Glutathione;Goals;graduate student;Health;Hepatocyte;Homeostasis;human disease;In Vitro;Iron;Kinetics;Ligand Binding;Link;Malignant Neoplasms;Mediating;Metabolic;Metabolic Pathway;metabolomics;Metals;Modification;Molecular;Mutagenesis;Nerve Degeneration;Neurodegenerative Disorders;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;Outer Mitochondrial Membrane;Oxidation-Reduction;Oxidative Stress;Oxygen Consumption;Parkinson Disease;Pathologic;Pathology;Pathway interactions;perpetrators;Pharmaceutical Preparations;Physiological;Play;Positioning Attribute;Property;protein expression;Proteins;Publishing;Pyridoxal Phosphate;Reaction;Research Personnel;Resources;response;Role;sensor;Signal Transduction;Substrate Specificity;Sulfhydryl Compounds;Sulfur;Sulfur Metabolism Pathway;Tertiary Protein Structure;transamination;undergraduate student;Work

PROJECT_TITLE: MitoNEET is a Regulator of the Cellular Thiol State in Health and Disease


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences;Nutrition

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Neuronal mechanisms that control selective behavioral attention to sensory cues have been a long-standing mystery. Hunger is a powerful motivational state that enhances attraction to food odors but not other olfactory cues through a Neuropeptide Y spotlight; thirst instead enhances attraction to drink odors, but neuronal mechanisms involved remain mysterious. Here, we leverage key molecular features of olfactory subcircuits to investigate (1) how various sensory inputs are distinctly represented in the brain, and (2) how two distinct physiological states- hunger and thirst- differentially influence sensory responses.

PI_NAMEs: LIBERLES, STEPHEN DANIEL (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Acute;Attention;Axon;Back;Behavior;behavior influence;Behavioral;Brain;Brain region;cell type;Cells;Cues;Data;detection platform;Enterobacteria phage P1 Cre recombinase;experimental study;Fasting;feeding;Fiber;Food;Fright;Genes;Genetic;genetic approach;Hunger;Hypothalamic structure;Injections;insight;Knock-in;Knock-out;Knockout Mice;Label;Measures;Mediating;Messenger RNA;Modeling;Molecular;motivated behavior;Motivation;mouse model;Mus;Nature;neural circuit;Neurons;neuropeptide Y;Neurosciences;Neurotransmitters;Odors;Olfactory Cortex;Olfactory Pathways;optogenetics;Output;parallel processing;Partner in relationship;Peptides;Perception;Pheromone;Photometry;Physiological;piriform cortex;preference;preoptic nucleus;Property;receptor;response;Role;Sensory;sensory input;Site;Stimulus;Stream;Structure of paraventricular nucleus of thalamus;Thalamic structure;Thirst;Time;Tracer;Training;Viral;Water;Wild Type Mouse

PROJECT_TITLE: State-dependent modulation of olfactory behavior

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: PROJECT NARRATIVE Physical activity is a modifiable health behavior that is among the most promising strategies for slowing cognitive decline and preventing Alzheimer’s Disease and related dementias. Although many strategies have been developed to promote physical activity in midlife and older adults, little is known about how to maintain behavior change following the end of a behavioral intervention. This Center will apply an experimental medicine approach to develop interventions that engage the targets that support long-term maintenance of behavior change and enhance cognitive function.

PI_NAMEs: CONROY, DAVID E. (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Academy;Acceleration;Address;Adherence;adherence rate;Adult;Advisory Committees;Affect;Affective;age group;age related;age-related disease;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;American;Artificial Intelligence;Association Learning;behavior change;Behavior Therapy;Behavioral Sciences;Blood Vessels;Clinical Trials;Cognition;cognitive change;cognitive enhancement;cognitive function;Communities;computer science;dementia risk;disability;Disease;effective intervention;Engineering;Epidemic;Evaluation;evidence base;exercise intervention;experience;Failure;flexibility;Generations;generative artificial intelligence;Goals;Guidelines;Habits;Health;Health behavior;Health Status;Impaired cognition;improved;Incidence;Industry;Intervention;knowledge translation;Lead;Maintenance;Mediator;Medicine;meetings;Methods;middle age;mobile computing;Modeling;Motivation;National Institute on Aging;Neurologic;novel;Observational Study;older adult;Personal Satisfaction;personalized intervention;Persons;Physical activity;Pilot Projects;Policy Maker;Population Heterogeneity;post intervention;predictive modeling;prevent;Prevention;Prevention strategy;Process;programs;prospective;Publications;Recommendation;Research;research and development;research data dissemination;Research Personnel;Research Project Grants;Resources;Scientific Advances and Accomplishments;Scientist;stem;synergism;Testing;therapy development;Time;Translational Research;Translations;United States;United States Agency for Healthcare Research and Quality;United States National Institutes of Health;wearable device;web app;Work

PROJECT_TITLE: Penn State Roybal Center for Promoting Adherence to Behavior Change and Enhancing Cognitive Function