NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: Project Narrative In this proposal, we aim to evaluate the role of patient experiences with care in racially and ethnically diverse older adult colorectal cancer (CRC) patients with comorbid chronic conditions. Using a population-based and nationally representative cohort from the SEER-CAHPS linked dataset, we aim to identify how ratings of patient experiences with care influence care received for both CRC and chronic conditions following cancer diagnosis, CRC survival, and overall costs of care for CRC patients with comorbid chronic conditions, as well as to determine how these relationships differ by patient race/ethnicity. These findings will inform how we can provide effective, efficient, and high-quality care for the vulnerable group of older adults with CRC and comorbid chronic conditions, as well as for the large and growing group of older adult patients with multimorbidity.

PI_NAMEs: NAVARRO, STEPHANIE ARIANA (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Adherence;Administrator;Adult;anti-cancer research;Area;California;cancer care;cancer diagnosis;Cancer Patient;cancer survival;Cancer Survivor;Cancer Survivorship;care coordination;care costs;care outcomes;care providers;care systems;Caring;Chronic;Chronic Disease;Chronic Kidney Failure;Chronic Obstructive Pulmonary Disease;Clinical;clinical training;cohort;colon cancer patients;Colorectal Cancer;colorectal cancer risk;Communication;comorbidity;Complex;Congestive Heart Failure;cost;Data;data registry;Data Set;Diagnosis;Disease Management;Disparate;Disparity;Doctor of Philosophy;Education;Epidemiology;ethnic difference;ethnic diversity;ethnic minority;ethnic minority population;Ethnic Origin;Ethnic Population;experience;Fee-for-Service Plans;Fellowship;follow-up;Goals;Guidelines;health assessment;health care disparity;Health Disparities Research;health disparity;health equity;Health Information System;Health Personnel;Health Services;Healthcare;Hospitalization;human old age (65+);improved;improved outcome;Individual;Inpatients;Intervention;late life;Link;Malignant Neoplasms;Medical Fee for Service;medical schools;medically underserved;Medicare;Mentors;minority patient;Modification;mortality;mortality risk;multiple chronic conditions;National Cancer Institute;neoplasm registry;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;older adult;Outcome;patient population;Patient-Centered Care;Patients;Physicians;Policy Maker;Population;population based;Primary Care;programs;Quality of Care;Race;racial difference;racial diversity;racial minority;racial minority population;racial population;Reporting;Research;Research Personnel;Research Training;Resources;Risk;Role;Sampling;SEER Program;skills;Stage at Diagnosis;Structure;Surveys;Survival Rate;survivorship;Training;Training Programs;Universities;Vulnerable Populations;Work

PROJECT_TITLE: The role of patient experiences with care in older adult colorectal cancer patients with comorbid chronic conditions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Genetics;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SAINT LOUIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSURGERY

ORG_FIPS: US

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Despite progress in surgery and chemoradiation therapies, the prognosis of the brain cancer glioblastoma remains challenging; in addition to the blood-brain barrier, treatment resistance in glioblastoma has been attributed to the intrinsic heterogeneity of these tumors. One specific glioblastoma cell type, the glioblastoma stem cell, has been the focus of intense investigation because these cancer cells can resist therapy and therefore drive tumor recurrence after treatment. Here we propose to examine the molecular regulation of the SOX2 transcription factor, which is critical for the malignant behavior of glioblastoma stem cells, with our long-term goal being to leverage SOX2-dependent mechanisms to halt tumor growth and overcome therapy resistance in patients.

PI_NAMEs: KIM, ALBERT HONG-JAE (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Adult;Aftercare;Behavior;Binding;Biological Models;Biology;Blood - brain barrier anatomy;Brain Neoplasms;cancer cell;cell type;Cells;Chemotherapy and/or radiation;ChIP-seq;Chromatin;Clinical;clinically relevant;Collaborations;CRISPR/Cas technology;Data;data integration;Disease;DNA;DNA Sequence Alteration;effective therapy;Engineering;Epigenetic Process;Failure;gain of function;Gene Expression;Gene Targeting;Genes;Genetic;Genetic Heterogeneity;Genetic Transcription;Genomics;Germ Cells;Glioblastoma;Goals;Heterogeneity;Human;human model;human stem cells;In Vitro;in vivo;insight;Investigation;Knowledge;Laboratories;Libraries;Ligase;loss of function;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;malignant phenotype;Mediating;Medicine;Molecular;multicatalytic endopeptidase complex;mutant;neoplastic cell;nerve stem cell;new therapeutic target;novel;Oncogenic;Operative Surgical Procedures;overexpression;Patients;Phenotype;Play;pluripotency;Post-Translational Regulation;Primary Brain Neoplasms;Process;Prognosis;programs;promoter;Proteins;Publishing;Radiation therapy;Recurrent disease;Recurrent tumor;Regulation;Resistance;RNA Interference;Role;Safe Sex;self-renewal;sex;Signal Transduction;Specific qualifier value;standard of care;stem cell biology;stem cell model;stem cell self renewal;stem cells;System;Technology;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapy resistant;transcription factor;transcriptome;treatment response;tumor;tumor growth;tumor heterogeneity;tumor initiation;Tumor-Derived;Tumorigenicity;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;Universities;Variant;virtual;Washington;Work

PROJECT_TITLE: Mechanisms of SOX2 Regulation in Glioblastoma

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Drug Abuse (NIDA only);Networking and Information Technology R&D (NITRD);Neurosciences;Substance Misuse

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PI_NAMEs: TANK, DAVID W (contact)

PROJECT_TERMS: Affect;Animal Behavior;Animals;Area;Back;Behavior;Behavioral;BRAIN initiative;Brain region;Calcium;Cells;Collaborations;Communities;Custom;Data;Data Science;Decision Making;design;Electron Microscopy;Ensure;Equipment;experimental study;extrastriate visual cortex;Geometry;Goals;Image;image registration;improved;innovation;instrument;instrumentation;Laboratories;Lasers;Maps;member;Methods;Microscope;Microscopy;multi-photon;Mus;neural;neural circuit;neural model;Neuroanatomy;neuroimaging;neuromechanism;Neurons;Neurosciences;new technology;Optics;optogenetics;Peripheral;Photons;Population;Process;Research Personnel;Research Project Grants;Resolution;Rodent;Running;Short-Term Memory;Standardization;System;Techniques;Technology;Time;two-photon;virtual reality;virtual reality environment;virtual reality system;Visualization

PROJECT_TITLE: C5: Optical Instrumentation


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Physical Activity;Prevention;Telehealth

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative Men in the United States have an exceptionally high prevalence of overweight and obesity, but are dramatically underrepresented in weight loss programs because they find them unappealing. This project evaluates engagement in and efficacy of a novel, game-based mobile weight loss program designed to be appealing to men. The program is designed to be especially effective and engaging because it features both gamification features known to enhance enjoyment and motivation and facilitate desired behaviors and neurotraining in basic brain capacities needed to resist impulses to eat tempting foods.

PI_NAMEs: HAGERMAN, CHARLOTTE  (contact)

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: Address;Advertising;attentional control;base;Behavior;behavior change;Behavioral;Beverages;Body mass index;Body Weight decreased;Brain;Calibration;Calories;Consumption;Counseling;design;Diet;dietary;Dietary intake;digital;Eating;Education;Educational workshop;efficacy evaluation;Elements;Enrollment;Event;Feedback;Feminine;Food;Frequencies;gender disparity;High Prevalence;Hour;Imagery;improved;Individual;innovation;interest;Investments;Link;male;Masculine;Meat;Mechanics;Mediator;men;Men's Role;mHealth;mobile application;Mobile Health Application;Monitor;Motivation;Music;novel;Obesity;Outcome;Overweight;Participant;peer;Physical activity;Play;preference;primary outcome;programs;Randomized;recruit;reinforcer;response;Rewards;role model;Sampling;secondary outcome;Self Direction;self help;Sports;success;sugar;Surveys;Testing;Training;United States;usability;Video Games;Weight;weight loss program;Woman;Work

PROJECT_TITLE: Engaging men in weight loss with a game-based mHealth and neurotraining program

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pain Research;Precision Medicine;Rehabilitation

ORG_CITY: SEATTLE

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative While behavioral treatments for chronic pain are effective on average, some people benefit greatly from treatment while others benefit very little, and the same person may respond much more to one type of treatment than another. This project aims to better understand the patient factors that could be used to identify – before treatment –who will benefit the most from each of three different chronic pain treatments: cognitive behavioral therapy, Hypnotic Cognitive Therapy, and Mindfulness-Based Cognitive Therapy. The knowledge gained from this research will provide an essential platform for developing algorithms to effectively match patients with chronic pain to treatments that are most likely to be benficial for them.

PI_NAMEs: JENSEN, MARK P (contact);WILLIAMS, RHONDA

PROGRAM_OFFICER_NAME: BELFER, INNA

PROJECT_TERMS: active method;Address;Affect;Aftercare;Algorithms;Analgesics;base;Behavior Therapy;Brain;chronic pain;chronic pain management;chronic pain patient;Clinical Trials;cognitive benefits;Cognitive Therapy;Complementary Health;Data;design;Disabling;effective therapy;Electroencephalography;Evidence based treatment;Foundations;Health Personnel;hypnotic;improved;Individual;individual patient;individual response;Integrative Medicine;Intervention;Knowledge;Measures;men;mindfulness;mindfulness based cognitive therapy;Nonpharmacologic Therapy;Outcome;outcome prediction;pain catastrophizing;Pain intensity;Pain management;pain reduction;Participant;Patients;Pattern;personalized care;Persons;pharmacologic;precision medicine;predicting response;Predictive Factor;primary outcome;programs;prospective;prospective test;Provider;psychosocial;Randomized;Research;response;secondary analysis;secondary outcome;shared decision making;Testing;theories;trait;treatment as usual;Treatment outcome;treatment response;Veterans;Woman

PROJECT_TITLE: Optimizing Response to Chronic Pain Treatments in Veterans: Identifying Key Moderators

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Estrogen;Infectious Diseases;Microbiome;Prevention;Urologic Diseases;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE Among postmenopausal women who suffer from recurrent urinary tract infections (UTI), vaginal estrogen therapy prevents UTI recurrences for 50% of sufferers. This research will investigate why some women benefit but others do not, focusing on (a) the effects of vaginal estrogen therapy on the bacteria that inhabit the vagina and bladder, (b) its influence on immune responses in both compartments, and (c) the extent to which those changes are critical to successful UTI prevention. The findings will be a first step in the development of more effective strategies to prevent UTI, one of the most common and costly benign urologic conditions.

PI_NAMEs: HANDA, VICTORIA LYNN (contact)

PROGRAM_OFFICER_NAME: REYNOLDS, WILLIAM STUART

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;Affect;Allergic Reaction;Alternative Therapies;Animals;Antibiotic Resistance;antibiotic resistant infections;Antibiotics;Atopobium vaginae;Bacteria;bactericide;beneficiary;Benign;Biological;biomarker identification;Bladder;Characteristics;Chronic;Clinical Trials;cost;cytokine;Data;design;Development;Dose;Effectiveness;Environment;Escherichia coli;Estrogen Therapy;Estrogens;evidence base;Exhibits;experience;Female;Funding Mechanisms;Genitourinary system;Goals;Growth;Hospitalization;Human;human data;Immune response;improved;Individual;Infection prevention;Inflammation;Inflammation Mediators;Lactic acid;Lactobacillus;Lower urinary tract;Macrophage;Measures;Mediating;Medicare;Menopause;microbial community;microbiota;Modernization;Modification;Molecular;Morbidity - disease rate;mortality;neutrophil;NIH Program Announcements;novel;older adult;older women;open label;Outcome;Participant;pathogen;Pathologic;Pathway interactions;Patients;Pilot Projects;Play;Population;Postmenopause;Predisposition;prevent;Prevention;Prevention strategy;Production;Prophylactic treatment;Pseudomembranous Colitis;Recurrence;recurrence prevention;recurrent infection;Research;response;Role;Sampling;Signal Pathway;Signal Transduction;Symptoms;Techniques;treatment response;urinary;Urinary Microbiome;Urinary tract infection;Urine;urogenital tract;urologic;Uropathogen;Vagina;vaginal lactobacilli;vaginal microbiome;vaginal microbiota;Woman

PROJECT_TITLE: Mechanisms of Successful Vaginal Estrogen Prophylaxis for Postmenopausal Women with Recurrent Urinary Tract Infections: Urogenital Microbiota and Host Immune Responses

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Pediatric;Substance Misuse

ORG_CITY: CHARLESTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Advancing diversity in the STEM pipeline has long been challenged by limited access to educational resources and fewer professional training opportunities for underrepresented minorities. The primary objective of the Teen Science Ambassador Program at the Medical University of South Carolina is to provide underrepresented high school students with a three phase internship experience designed to increase real- world academic research involvement, develop professional and mentorship skills, network with STEM professionals, and prepare for careers in STEM fields. Achieving this goal will contribute to NIH’s mission to support educational activities that complement and enhance the training of a workforce to meet the nation’s biomedical, behavioral, and clinical research needs.

PI_NAMEs: SQUEGLIA, LINDSAY  (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Address;adolescent substance use;Advisory Committees;Award;Awareness;Behavioral Research;Biomedical Research;career;Career Choice;career preparation;Clinical;clinical care;Clinical Research;Common Core;Communication;Communities;community based participatory research;Community Health;Complement;cultural competence;curriculum development;design;Development;Dissemination and Implementation;Doctor of Medicine;Doctor of Philosophy;Education;education resources;Educational Activities;Educational Curriculum;Elements;Ensure;Evaluation;experience;Exposure to;Faculty;Festival;Fostering;Funding;Goals;hands on research;health literacy;high school;High School Student;improved;innovation;Institution;interest;Internships;Interview;Knowledge;Leadership;Learning;Logic;Medical;meetings;Mental Health;Mentors;Mentorship;method development;Minority Participation;Mission;Modeling;multidisciplinary;next generation;Next Generation Science Standards;Oral;Outcome;outreach;peer;peer coaching;Phase;Postbaccalaureate;Principal Investigator;Probability;Process;Program Evaluation;programs;Public Health;Qualifying;Research;Research Activity;Research Methodology;Research Project Grants;Research Support;Resources;retention rate;Review Literature;Schools;Science;science education;scientific literacy;Scientist;Self Efficacy;Series;Services;skill acquisition;skills;South Carolina;STEM career;STEM field;Structure;Students;success;Teenagers;tenth grade;Testing;Training;training opportunity;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Universities;Update;web site;Writing;Youth

PROJECT_TITLE: MUSC High School Teen Science Ambassador Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: BIOLOGY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

ORG_STATE: NY

PHR: Project Narrative Maintenance of a properly distributed, healthy population of mitochondria is critical for neuronal function. Fundamental molecular and cellular mechanisms for coordinating mitochondrial dynamics over space and time in vivo are likely to be conserved in neurons across species. Thus, by determining how neurons maintain mitochondrial homeostasis in a tractable model system—the Drosophila visual system—we seek to provide a mechanistic framework for understanding how mitochondrial defects contribute to neurodegenerative diseases including Alzheimer's disease and Parkinson's disease.

PI_NAMEs: BARNHART, ERIN L (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Active Biological Transport;Affect;Alzheimer's Disease;Architecture;Axon;Binding;Biological Models;Cell Culture System;Cell Culture Techniques;cell type;Cells;Complement;Complex;Data Set;Defect;Dendrites;Diffusion;Distal;Drosophila genus;Ensure;experimental study;fly;Genetic;Goals;Health;Homeostasis;imaging approach;in vivo;in vivo imaging;in vivo imaging system;Individual;innovation;insight;Label;Link;Maintenance;mathematical model;Measurement;Measures;meter;millisecond;Mitochondria;mitochondrial autophagy;Mitochondrial Proteins;Modeling;Molecular;Morphology;Motility;Motion;Movement;nanometer;Neurodegenerative Disorders;neuronal cell body;Neurons;Organism;Outcome;oxidative damage;Parkin;Parkinson Disease;Pattern;Physiological;PINK1 gene;Play;Population;predictive modeling;prevent;Role;self organization;Spatial Distribution;spatiotemporal;Stress;System;Testing;Time;tool;Vision;visual stimulus;Visual System

PROJECT_TITLE: How Do Neurons Maintain Mitochondrial Homeostasis in Vivo?

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_DEPT: SURGERY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Narrative A renewal of this T32 program designed to continue training aspiring physician-scientists in GI cancer research. Trainees are drawn from Medical Oncology, Radiation Oncology, Surgery, and Gastroenterology and will enroll in either a Basic/Translational Science track or a Population Science track led by mentors accomplished in both scientific research and training. Our goal is to graduate physician-scientists armed with the capacity and credentials to lead their own innovative research programs and develop into leaders in investigative GI oncology.

PI_NAMEs: BAR-SAGI, DAFNA  (contact);WOLFGANG, CHRISTOPHER L.

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TITLE: Research Training for Physician-Scientists in Gastrointestinal Oncology

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Infectious Diseases;Pediatric;Sepsis

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: PROJECT NARRATIVE – Children’s National Hospital Pediatric sepsis and multiple organ failure are identified as conditions that adversely affect the public health of  children by NICHD, leading to increased mortality and morbidity. Beside supportive care with antibiotics,  resuscitative measures to augment oxygen delivery and mechanical support for failing organs, no therapies have  been identified to decrease the burden of illness for children with multiple organ dysfunction syndrome (MODS).  In this new application, the Collaborative Pediatric Critical Care Research Network will perform two randomized  controlled trials to determine whether immunomodulation after sepsis-induced MODS decreases organ failure  and improves outcomes.

PI_NAMEs: BELL, MICHAEL J (contact);WESSEL, DAVID LLOYD

PROGRAM_OFFICER_NAME: JENKINS, TAMMARA L

PROJECT_TERMS: Acute;Admission activity;Affect;Antibiotics;Area;Ascorbic Acid;Biological Markers;Brain;burden of illness;Cardiac;career;Chest;Child;Child Development;Child Health;Childhood;clinical care;clinical center;Clinical Research;clinical research site;Clinical Trials;Collaborations;Communities;Contracts;Critical Care;Critical Illness;Critically ill children;Data;Data Coordinating Center;Delirium;design;Development;disability;District of Columbia;Enrollment;Ensure;expectation;experience;Faculty;Family;functional outcomes;functional status;Funding;Goals;Good Clinical Practice;Guideline Adherence;Health;health assessment;health related quality of life;Healthcare Systems;Hospitals;Human Resources;Hypoxemic Respiratory Failure;immunoregulation;improved;improved outcome;Individual;Inflammation;Injury;innovation;Institution;Lead;Maryland;Measures;Mechanics;Medicine;meetings;member;Morbidity - disease rate;mortality;Multicenter Studies;Multiple Organ Failure;Neurologic;Nitric Oxide;novel strategies;novel therapeutic intervention;Observational Study;Organ;Organ failure;Outcome;outcome prediction;Oxygen;participant enrollment;Patient Care;Patients;Pediatric Hospitals;pediatric sepsis;pediatric trauma;pediatric traumatic brain injury;Performance;Personal Satisfaction;personalized medicine;Principal Investigator;Procedures;Productivity;Protocols documentation;Public Health;Quality of life;Randomized, Controlled Trials;Recovery;Research;Research Personnel;Research Proposals;research study;Research Training;Resources;Running;Scientist;Sedation procedure;Sepsis;Sickle Cell Anemia;Site;skills;Sleep;Specialist;Standardization;success;Supportive care;systematic review;T cell regulation;Talents;Testing;Training;Traumatic Brain Injury;Virginia;Washington;Work

PROJECT_TITLE: Collaborative Pediatric Critical Care Research Network - Clinical Site


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Emergency Care;Mental Health;Physical Injury - Accidents and Adverse Effects;Prevention;Violence Research

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Although Guyana has the highest rates of morbidity burden in South America, much of it due to preventable death and disability resulting from suicide, violence, road accidents, and other traumas and injuries, the country lacks sufficient public health research capacity to effectively address these issues. The proposed Guyana Research in Injury and Trauma Training (GRITT) Program, a Sister program to the Columbia (University) Center for Injury Science and Prevention (CCISP), is designed to support training within the University of Guyana, the Georgetown Public Hospital Corporation, the Accident and Emergency Department and Guyana Emergency Medical Services, and Columbia University, providing Guyanese scientists with the skills to conduct rigorous trauma/injury research. This training program is designed to prepare researchers to develop, implement, and evaluate evidence-based trauma/injury prevention interventions specific to local needs, with the ultimate goal of improving the safety and longevity of the Guyanese people.

PI_NAMEs: HOVEN, CHRISTINA W. (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Accident and Emergency department;Accidents;Address;Area;career;certificate program;Collaborations;Country;Degree program;design;Discipline;Discipline of Nursing;Doctor of Philosophy;Education;Educational workshop;Emergency medical service;Ensure;Epidemiology;evidence base;Faculty;Funding;Guyana;hands on research;hands-on learning;Health;Health Professional;Healthcare;Individual;Ingestion;Injury;injury prevention;Institution;Interpersonal Violence;Leadership;Medical;Mentors;mortality;National Institute of Mental Health;Occupations;Pathway interactions;Pesticides;Pharmacy facility;Prevention;Prevention strategy;Process;Professional Role;programs;Psychology;Public Health;Public Health Schools;Public Hospitals;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Training;Science;Self-Injurious Behavior;Series;Sister;Social Work;South America;Students;Suicide;suicide rate;Teacher Professional Development;Techniques;Training;Training Programs;Trauma;Universities;Variant;Violence;virtual


ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: LITTLE ROCK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE  Many cancer patients and survivors suffer from adverse effects of treatment that can present during and after the completion of cancer therapy. The COBRE Center for Studies of Host Response to Cancer Therapy brings together and supports investigators from various disciplines who perform research to understand mechanisms by which cancer therapy causes adverse effects; identify new methods for early detection of side effects; and develop novel strategies to reduce these side effects. The overall goal is to build a self-sustaining research center that aids in making cancer treatment safer and maximize the number of uncomplicated cancer cures.

PI_NAMEs: BOERMA, MARJAN  (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: Address;Adverse effects;Advisory Committees;Affect;Aftercare;Animals;anti-cancer treatment;Applications Grants;Arkansas;Award;base;Biological;Biomedical Research;Cancer Detection;Cancer Patient;Cancer Survivor;Cancer Survivorship;cancer therapy;career;Centers of Research Excellence;chemotherapy;Chemotherapy and/or radiation;Chronic;Clinical;Collaborations;comparative;Dedications;Development;Development Plans;disability;Discipline;Dose Limiting;Early Diagnosis;effective intervention;Ensure;Environment;Extramural Activities;Faculty;Fee-for-Service Plans;Funding;Funding Agency;Goals;Immune response;Immune system;improved;Individual;Institution;Interdisciplinary Study;interest;Life;Malignant Neoplasms;Medical;Mentors;Methods;multidisciplinary;novel strategies;Oncology;Pediatric Hospitals;Phase;Pilot Projects;Predisposition;Preparation;prevent;Process;Productivity;programs;psychosocial;Qualifying;Quality of life;quality of life for cancer survivors;Radiation;Radiation therapy;recruit;Research;Research Infrastructure;Research Institute;Research Personnel;Research Project Grants;Research Support;Resources;response;Role;Science;Scientist;Secure;Services;side effect;Structure;success;synergism;Teacher Professional Development;Therapeutic;therapy adverse effect;Tissues;Toxicology;translational approach;Translational Research;Treatment Efficacy;Treatment outcome;Treatment-Related Cancer;Treatment-related toxicity;tumor;United States National Institutes of Health;Universities


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Patient Safety

PROJECT_TERMS: Acceleration;Address;Adverse effects;Advisory Committees;Animals;Applications Grants;Area;Arkansas;Cancer Patient;cancer survival;Cancer Survivor;cancer therapy;Centers of Research Excellence;Communication;design;detection method;disability;Discipline;Doctor of Philosophy;Ensure;Environment;Evaluable Disease;Evaluation;experience;Fees;Funding;Goals;Grant;Growth;Immune response;improved;Infrastructure;Institution;Intestines;irradiation;Journals;Life;Malignant Neoplasms;Manuscripts;Medical;meetings;Mentors;Methods;multidisciplinary;novel strategies;Occupational activity of managing finances;Oncology;operation;Patients;Peer Review;Persons;Phase;Pilot Projects;prevent;Productivity;Program Development;programs;Publications;Quality of life;quality of life for cancer survivors;Radiation Injuries;recruit;Research;Research Personnel;Role;Schedule;Science;Scientist;Series;Services;side effect;Structure;success;Survivors;synergism;Teacher Professional Development;Toxic effect;Toxicology;Translational Research;Universities;Writing

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: NEW HAVEN

ORG_DEPT: PATHOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PI_NAMEs: KLEINSTEIN, STEVEN H. (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;age group;Algebra;algorithm development;Algorithms;Area;Biological;Clinical;Communities;Complex;complex data;Data;Data Analyses;data complexity;data integration;Data Reporting;Data Set;design;Development;dimension reduction;Dimensions;Face;Gene Expression;Genes;Goals;high dimensionality;Immune;Immunology;improved;indexing;Infection;Joints;Mathematics;metabolomics;Methodology;Methods;Multiomic Data;multiple omics;National Institute of Allergy and Infectious Disease;novel;novel strategies;Outcome;Pathogenicity;patient subsets;Pattern;Platelet Activation;prevent;Principal Component Analysis;Process;programs;Proteomics;Recovery;Research;Research Design;Research Personnel;Resolution;response;Risk;Sampling;Source;Structure;Technology;Testing;Time;Tissues;tool;transcriptome sequencing;two-dimensional;usability;Vaccination;Variant;vector

PROJECT_TITLE: Tensor decomposition methods for multi-omics immunology data analysis


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Microbiome;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Alzheimer’s disease and other dementias remain a leading cause of mortality and morbidity worldwide, and IL17-producing T-helper lymphocytes (Th17 cells) have been implicated in the mechanisms of cognitive impairment. Since, Th17 cells are particularly abundant in the gut and are sensitive to gut bacteria, the present application seeks to explore the novel hypothesis that dysregulation of gut Th17 homeostasis, induced by gut microbiota, promotes an IL17-mediated inflammatory response in cerebral endothelial cells which, in turn, activates microglia, leading to tau accumulation and cognitive impairment. The proposed studies open the way to future research to develop approaches to contain the harmful effects of gut Th17 cells and IL17 on brain health and cognitive function.

PI_NAMEs: FARACO, GIUSEPPE  (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: abeta deposition;Affect;age group;age-related disease;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Animal Model;Applications Grants;Arthritis;Bacteria;base;Blood;Brain;brain cell;brain endothelial cell;brain health;cardiovascular risk factor;Cells;Cerebral endothelium;cerebral microvasculature;cerebrovascular;Cerebrovascular Disorders;Clinical;Cognition;cognitive function;commensal bacteria;commensal microbes;Communication;cytokine;Data;Dementia;dementia risk;Development;Diabetes Mellitus;dietary salt;Disease;Disease Progression;Endothelial Cells;Endothelium;Female;Functional disorder;gut bacteria;gut microbiota;Helper-Inducer T-Lymphocyte;Homeostasis;Human;hyperphosphorylated tau;IL17 gene;Immune;immune activation;Immune system;Immunity;Impaired cognition;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Bowel Diseases;inflammatory marker;Inflammatory Response;Intestines;Link;Maintenance;male;Mediating;member;microbiota;microbiota composition;Microglia;Microtubule-Associated Proteins;mild cognitive impairment;Modeling;Morbidity - disease rate;mortality;mouse model;Multiple Sclerosis;Mus;neuroinflammation;neuropathology;neurovascular;neutralizing antibody;Nitric Oxide;novel;old mice;Pathologic;Pathology;Patients;Peripheral;Play;pre-clinical;Process;Public Health;receptor;Regulation;response;Role;salt intake;Sex Differences;Signal Transduction;Small Intestines;tau aggregation;tau Proteins;tau-1;Testing

PROJECT_TITLE: Gut Immunity, Neurovascular Dysregulation and Cognitive Impairment


NIH_SPENDING_CATS: Aging;Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation;Sleep Research

ORG_CITY: OMAHA

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative With this study, we will gain a better understanding of how the basal ganglia contribute to pathological sleep behavior in humans. This information will be used to understand better how the brain regulates sleep and how we can intervene therapeutically in sleep regulation in order to develop new therapies for sleep disorders both for patients with Parkinson’s disease and for other populations suffering from dysfunctional sleep. In addition, we will use these results to improve the accuracy of sleep dysfunction diagnoses, enabling the application of existing therapies more appropriately, and the development of novel therapies.

PI_NAMEs: ABOSCH, AVIVA  (contact);HALPERN, CASEY HARRISON;KUSHIDA, CLETE A;THOMPSON, JOHN A

PROGRAM_OFFICER_NAME: FRANKOWSKI, MEGAN MICHELLE

PROJECT_TERMS: actigraphy;Address;Affect;Algorithms;artificial neural network;Attention;Basal Ganglia;Beds;Behavior;Behavior Disorders;Biological Markers;Bradykinesia;Brain;BRAIN initiative;Caregivers;Clinical;clinical research site;Cognition;Control Groups;Crossover Design;Deep Brain Stimulation;Development;Devices;Diagnosis;Disabling;Double-Blind Method;Dyskinetic syndrome;effective therapy;efficacy testing;Electrodes;Electrophysiology (science);Excessive Daytime Sleepiness;Exhibits;experience;experimental group;General Population;Home;Homeostasis;Human;hypnotic;Impairment;Implant;implantation;Implanted Electrodes;improved;improvement on sleep;insight;Investigation;Lead;Maintenance;Masks;Medical;Mission;Moods;Morbidity - disease rate;mortality;Motor;motor symptom;National Institute of Neurological Disorders and Stroke;Nature;Nervous System;neural stimulation;Neurodegenerative Disorders;non-motor symptom;novel;novel therapeutics;Operative Surgical Procedures;Parkinson Disease;Pathologic;patient population;Patients;Pattern;Pharmaceutical Preparations;Phase;Polysomnography;Population;potential biomarker;Protocols documentation;prototype;Quality of life;Regulation;REM Sleep Behavior Disorder;repaired;Reporting;response;Restless Legs Syndrome;sedative;side effect;Signal Transduction;Site;Sleep;Sleep Architecture;sleep behavior;Sleep Disorders;Sleep Disorders Therapy;Sleep disturbances;Sleep Fragmentations;sleep quality;sleep regulation;Sleep Stages;Sleeplessness;Slow-Wave Sleep;specific biomarkers;STN stimulation;Structure;Structure of subthalamic nucleus;symposium;Symptoms;System;Technology;Testing;Therapeutic;Time;Tremor;Work

PROJECT_TITLE: Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease: An Investigation of STN LFP Biomarkers In Sleep Dysregulation and Repair


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Hearing Loss;Neurosciences;Pediatric;Prevention;Rehabilitation

ORG_DEPT: OTOLARYNGOLOGY

PHR: Narrative Children who are deaf in one ear and wear a hearing aid or have normal hearing in the other ear struggle with daily communication. A cochlear implant (CI) is the only treatment that can restore hearing to a deaf ear and establish bilateral input, essential for speech understanding in noise and sound localization. Critical information will be gained from this study regarding the CI as a treatment option for this underserved pediatric population.

PI_NAMEs: FIRSZT, JILL B (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Acoustics;Address;Adverse event;Affect;Age;Assessment tool;asymmetric hearing loss;Auditory;Behavioral;Bilateral;Binaural;binaural hearing;Caring;Child;Childhood;Clinical;Clinical Management;Clinical Treatment;Clinical Trials;Cochlear implant procedure;Cochlear Implants;Communication;Communication difficulty;Complex;Consensus;Contralateral;Cues;Data;deaf;deafness;design;Detection;Development;Devices;Ear;Education;effectiveness evaluation;Environment;evidence base;Family;Fatigue;FDA approved;Grant;Growth;Hearing;Hearing Aids;hearing impairment;hearing restoration;Implant;implantation;improved;Intervention;Manufacturer;Measures;Medical;Methodology;Modality;Multi-Institutional Clinical Trial;Multicenter Studies;Noise;normal hearing;Outcome;Outcome Study;Patient Selection;Performance;Phase;Population;prospective;Protocols documentation;Quality of life;Route;Safety;Schools;Severities;Side;Signal Transduction;social;sound;Sound Localization;Source;Speech;speech in noise;speech recognition;Standardization;Stress;Technology;Testing;Time;Underserved Population

PROJECT_TITLE: Cochlear Implantation in Children with Asymmetric Hearing Loss or Single Sided Deafness Clinical Trial


NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Networking and Information Technology R&D (NITRD);Neurosciences;Rehabilitation

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE People with severe speech and motor impairment often have difficulty with accessing communication technology, which is increasingly based on interaction with computers. This project aims to develop new methods of interacting with computers via decoding newly discovered brain signals to provide faster and more facile communication. Successful completion of this project could allow this marginalized segment of the US population to once again have the means to manage their health care, form meaningful relationships, have a means for recreation and entertainment, and interact socially with their health care providers and loved ones.

PI_NAMEs: DRUCKMANN, SHAUL ;HENDERSON, JAIMIE M (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: Adult;Area;arm;Augmentative and Alternative Communication;Body part;Brain;brain computer interface;BRAIN initiative;Classification;Clinical Research;clinical research site;Cognitive;Collaborations;Communication;communication device;Complex;computational platform;Computers;Contralateral;design;Dimensions;Electronic Mail;Evaluation;falls;first-in-human;Four-dimensional;Freedom;Funding;Generations;Goals;Hand;Health Personnel;Healthcare;high dimensionality;Home;Human;Implant;improved;Institution;Internet;Ipsilateral;kinematics;Left;Letters;literate;loved ones;Lower Extremity;Maps;marginalization;Measures;Methods;mobile computing;Modernization;Motor;Motor Cortex;motor impairment;Movement;Mus;National Institute on Deafness and Other Communication Disorders;neural;nonhuman primate;novel;Outcome;Participant;Performance;performance tests;Persons;Population;Procedures;Prosthesis;Quadriplegia;Recreation;Research;Research Support;Signal Transduction;Site;Social Interaction;Source;Speech;Speed;Standardization;success;System;Tablet Computer;Techniques;Technology;Testing;tool;two-dimensional;ubiquitous computing;United States National Institutes of Health;Upper Extremity;virtual;wireless;Work

PROJECT_TITLE: Engaging new cognitive and motor signals to improve communication prostheses

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: FARMINGTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: PROJECT NARRATIVE OVERALL While aging affects everyone, the manner in which it impacts one’s capacity to remain healthy and independent late in life varies greatly between individuals. Our goal in establishing a Claude D Pepper Older Americans Independence Center at UConn is to learn from such variability and use that knowledge to promote the development of new approaches to the care of older adults that are more precise, more personalized and more effective.

PI_NAMEs: FORTINSKY, RICHARD H;KUCHEL, GEORGE A (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Address;Affect;Aging;aging related;American;Area;ARHGEF5 gene;Award;Behavior;Behavioral;bench to bedside;Biological;Biological Markers;Capsicum;career;Caring;Clinical;clinical care;Clinical Investigator;clinical translation;Clinical Trials;Cognition;collaborative approach;Communities;community engagement;data resource;design;Development;Dimensions;Discipline;Disease;Education;education research;Effectiveness of Interventions;Environmental Risk Factor;Epidemiologist;experience;Foundations;Funding;Genetic;Genomic medicine;Geriatrics;Gerontology;Geroscience;Goals;Growth;Health;Heterogeneity;Home;Host Defense;improved;Individual;innovation;insight;Institution;interdisciplinary approach;Intervention;Knowledge;Leadership;Learning;Life;Mission;multidisciplinary;multiple chronic conditions;next generation;novel;novel strategies;older adult;Outcome;Physiological;Pilot Projects;population based;pre-clinical;pre-clinical research;precision medicine;preference;programs;recruit;Research;Research Methodology;Research Personnel;research study;Resources;Science;Scientist;social;social factors;synergism;Techniques;Testing;The Jackson Laboratory;Time;tool;treatment response

PROJECT_TITLE: Claude D. Pepper Older Americans Independence Center (P30 Clinical Trial Optional)


NIH_SPENDING_CATS: Aging

PI_NAMEs: KUCHEL, GEORGE A (contact)

PROJECT_TERMS: Address;Aging;American;Animals;bench to bedside;Capsicum;Clinical;Clinical Research;Clinical Trials;Collaborations;Committee Members;Communities;community advisory board;Connecticut;design;Development;Doctor of Philosophy;Education;education research;Educational Activities;Elderly;Ensure;Environment;Evaluation;Evaluation Research;experience;Faculty;Funding;Geriatrics;Gerontology;Goals;Growth;human subject;improved;Infrastructure;interest;Knowledge;Laboratories;Lead;Leadership;Medical;medical schools;meetings;member;Mission;Monitor;Motivation;multidisciplinary;older adult;Older Population;Population;population based;Population Study;Preparation;Productivity;professor;programs;Progress Reports;Publishing;Regulation;Research;Research Activity;Research Methodology;Research Support;Resources;restoration;Science;sociologist;tool;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Leadership and Administrative Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Heart Disease;Nutrition;Obesity;Prevention

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project Narrative In this proposal, we test the hypothesis that in the context of obesity, weight loss results in a plateau phase that is marked by a decrease in mitochondrial metabolism in multiple cell types (immune cells, hepatocytes, and myocytes) that give rise to reduced energy expenditure and increased susceptibility to cardiometabolic risk. These changes could contribute to the almost universal tendency for weight to be regained after weight loss by lifestyle changes, thus limiting the ability of weight loss to reduce cardiovascular disease risk over the long- term. Our results will provide new insights that could lead to future therapeutic approaches to promote the extent and maintenance of weight loss and reduce the cardiovascular risk associated with obesity.

PI_NAMEs: VALENCIA, ANA PATRICIA (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Acceleration;Address;Adherence;analytical tool;Animals;Area;Arterial Fatty Streak;Atherogenic Diet;Atherosclerosis;Basic Science;Behavioral;Bioenergetics;Biological;Biology;Body Composition;Body Weight decreased;Carbohydrates;cardiometabolic risk;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;career;career development;CCL2 gene;Cell Separation;cell type;Cells;Clinical;Clinical Research;Data;Diet;diet-induced obesity;Dyslipidemias;Energy Metabolism;experience;experimental study;Exposure to;Fatty acid glycerol esters;Fatty Acids;Foundations;Funding;Future;Genetic;Goals;healthy weight;Hepatocyte;Human;human model;Immune;In Vitro;Indirect Calorimetry;Individual;Inflammation;insight;Institution;Insulin Resistance;insulin sensitivity;Interleukin-10;Interleukin-6;Knowledge;Learning;Life Style;Link;Lipids;Liver;lonely individuals;Magnetic Resonance;Measures;Mediating;Mentorship;Metabolic;metabolic phenotype;Metabolism;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;monocyte;Monocytosis;Mononuclear;mouse model;Mus;Muscle;Muscle Cells;Muscle Mitochondria;Neutrophilia;novel;nutrition;Obesity;Oxidants;oxidation;Oxidation-Reduction;Participant;Peripheral;Persons;Phase;Predisposition;prevent;Production;programs;protein expression;Recommendation;Relapse;Research;Research Activity;Resistance;Respiration;respiratory;response;Risk;Risk Factors;Rodent;Rodent Model;Role;Sampling;Serum;Skeletal Muscle;Stress;System;T-Lymphocyte;Techniques;Testing;Therapeutic;Thinness;Time;Tissues;TNF gene;Training;Translational Research;United States National Institutes of Health;Weight;weight maintenance;Weight maintenance regimen

PROJECT_TITLE: The role of mitochondrial metabolism in weight loss


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Asthma;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: The objective of the RI-CCTC is to enhance the health of children for generations to come, by building on our successes in the ECHO ISPCTN and ECHO Program in the initial award period. The RI-CCTC has built a robust research infrastructure, been a top site in enrolling participants and developing new clinical trials, and enhanced research capacity by developing and mentoring new investigators. Rhode Island offers a unique and diverse population of children to achieve the goals of the ECHO program.

PI_NAMEs: CHUN, THOMAS H (contact);DENNERY, PHYLLIS A.;LAPTOOK, ABBOT R

PROGRAM_OFFICER_NAME: RAJU, TONSE N

PROJECT_TERMS: Admission activity;Applied Research;Area;Asthma;autism spectrum disorder;Award;Centers of Research Excellence;Child;Child Health;Childhood;Childhood Asthma;Clinical;clinical center;Clinical Research;Clinical Trials;Collaborations;community engagement;Discipline of obstetrics;Education;Educational workshop;Emergency Care;Enrollment;Ensure;Environmental Exposure;Evaluation;evidence base;Exclusion;experience;Faculty;follow-up;Follow-Up Studies;Funding;Generations;Gifts;Goals;Grant;Health;health care availability;Health Policy;Healthcare;high risk population;Hospitals;Immigrant;improved;Infant;Infant Mortality;innovation;Institution;interest;Leadership;medical schools;Medicine;Mental Health;Mentors;Methods;Migraine;Minority;minority children;Mission;Multi-Institutional Clinical Trial;Multicenter Neonatal Research Network;Multicenter Studies;Neonatal;next generation;Obesity;opioid withdrawal;Parents;Participant;participant enrollment;pediatric department;pediatric emergency;Pediatric Hospitals;Pediatric Research;Pediatrics;Perinatal;population based;Population Heterogeneity;postnatal;premature;prenatal;Principal Investigator;Procedures;Process;Productivity;Program Development;programs;protocol development;Protocols documentation;Provider;Public Health;Public Health Schools;Publications;Registries;Research;Research Infrastructure;Research Methodology;Research Personnel;Resources;Rhode Island;Rural;Science;Scientist;senior faculty;Services;Site;success;Teacher Professional Development;Training;Translational Research;United States National Institutes of Health;Universities;Weaning;Woman;Work;Writing

PROJECT_TITLE: Rhode Island Child Clinical Trials Collaborative


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PHR: PROJECT NARRATIVE Recruitment and Community Engagement Core (RC1) RC1 will facilitate precision recruitment and retention and establish customized procedures for planning and managing recruitment activities and services for OAIC investigators focused on Precision Gerontology. RC1 will enhance community partnerships to engage diverse older adults in research, will educate older adults and the research community about including older adults in research, and provide human subjects ethical and regulatory support to OAIC investigators.

PI_NAMEs: ROBISON, JULIE THOMPSON (contact)

PROJECT_TERMS: African American;Aging;American;Behavior Therapy;biomarker discovery;biomarker validation;Black, Indigenous, People of Color;Capsicum;Clinical Trials;Code;cohort;Collaborations;Communities;community based participatory research;community engagement;community involvement;community living;community partnership;COVID-19 pandemic;Data Analyses;Data Pooling;Data Set;Databases;Development;Diagnosis;disability;early detection biomarkers;Education;Enrollment;Equity;equity, diversity, and inclusion;Ethics;experience;frailty;functional improvement;Funding;Gait speed;Gerontology;Goals;Grant;Health;health disparity;Heterogeneity;human subject;improved;Individual;innovation;Inpatients;Insurance;interest;Intervention;Investigation;Laboratories;life span;Long-Term Care;Measures;Medical;Medical Records;Mental Depression;Methods;Mission;Names;novel;older adult;Online Systems;Outcome;Outpatients;outreach;parent grant;Participant;participant retention;Patient Recruitments;Patient-Focused Outcomes;Patients;people of color;Physical Function;Policies;Population;Population Heterogeneity;Procedures;programs;protocol development;Provider;recruit;Recruitment Activity;Registries;Research;Research Institute;Research Personnel;research study;Resources;retention rate;Science;Services;Source;Standardization;System;tool;United States Centers for Medicare and Medicaid Services;United States National Institutes of Health;volunteer

PROJECT_TITLE: Recruitment Core RC1


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Myocardial infarction (MI) remains a leading cause of morbidity and mortality worldwide. The goals of this project are to understand the mechanism of abnormal blood vessel formation in the infarcted tissue and to develop new vascular therapy for improving heart repair after MI.

PI_NAMEs: FAN, YI  (contact);GONG, YANQING

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: angiogenesis;Angiogenic Factor;Anterior Descending Coronary Artery;Biology;Biomedical Engineering;blood perfusion;blood vessel development;Blood Vessels;cadherin 5;Cardiac;cardiac repair;Cardiology;Cause of Death;Cell Lineage;cell motility;Cell Proliferation;Cells;Clinic;Clonal Expansion;Coronary artery;coronary fibrosis;Development;Echocardiography;Embryonic Development;Endothelial Cells;Endothelium;Ensure;Exhibits;Fibroblasts;Gene Expression Regulation;Genes;Genetic;Glioma;Goals;Growth;Heart failure;heart function;HIF1A gene;Human;improved;In Vitro;in vivo;Infarction;Inflammation;inhibitor;insight;Interdisciplinary Study;Investigational Therapies;Ischemia;Knockout Mice;Left;Ligation;Malignant Neoplasms;Mediating;Mesenchymal;Modeling;Molecular;Morbidity - disease rate;mortality;Motility;Mus;myocardial damage;Myocardial Infarction;Myocardial Ischemia;Myocardial tissue;nanoparticle;Nature;neovascularization;NF-kappa B;novel therapeutics;Outcome;Pathologic;PDGF inhibition;PDGFRB gene;pharmacologic;Phase;Phenotype;Phosphotransferases;Platelet-Derived Growth Factor;Platelet-Derived Growth Factor beta Receptor;Platelet-Derived Growth Factor Receptor;Proliferating;Proteins;Recovery;Recovery of Function;repair function;repaired;Reperfusion Therapy;Research Personnel;restoration;Role;Science;single-cell RNA sequencing;Small Interfering RNA;Smooth Muscle Myocytes;Snails;stem-like cell;Structural defect;Structure;targeted treatment;Technology;Testing;Therapeutic;therapeutic target;Time;tissue repair;Tissues;transcription factor;transcriptome;trend;tumor microenvironment;vascular abnormality;Vascular Endothelial Growth Factors;Vascularization;Western World;Work

PROJECT_TITLE: Endothelial plasticity in cardiac repair after myocardial infarction

STUDY_SECTION: MIM

STUDY_SECTION_NAME: Myocardial Ischemia and Metabolism Study Section[MIM]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Neurosciences;Opioids;Pain Research

ORG_CITY: GALVESTON

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: Project Narrative Discontinuation of prolonged therapeutic opioid use is therapeutically beneficial for many chronic pain patients but difficult to accomplish. Transcutaneous auricular neurostimulation (tAN) is a safe and effective treatment for pain during opioid withdrawal. The proposed interdisciplinary investigation will elucidate the neurochemical and neurophysiological mechanisms of tAN-based analgesia and lead to treatment optimization and precision implementation.

PI_NAMEs: BORCKARDT, JEFFREY J;CUNNINGHAM, KATHRYN A.;KHODAPARAST, NAVID ;WILKES, DENISE  (contact)

PROGRAM_OFFICER_NAME: HUDAK, ERIC MICHAEL

PROJECT_TERMS: Absence of pain sensation;Acute;Adult;Adverse reactions;Affect;Alternative Therapies;alternative treatment;Analgesics;antinociception;Autonomic nervous system;Biomedical Engineering;Brain;Brain Stem;chronic pain;chronic pain management;chronic pain patient;Clinical;clinical application;Clinical Data;clinical efficacy;clinical pain;Clinical Research;Cranial Nerves;Data;Dependence;Devices;Dose;Double-Blind Method;effective therapy;endogenous opioids;Equilibrium;experience;Experimental Designs;External Ear;Functional Imaging;Functional Magnetic Resonance Imaging;Goals;Guidelines;Individual;interdisciplinary approach;Investigation;Label;Lead;Modality;Modeling;Morphine;negative affect;neonate;neural;neurochemistry;neurophysiology;neuroregulation;neurotransmission;non-opioid analgesic;novel;Opioid;opioid epidemic;opioid tapering;opioid therapy;opioid use;opioid withdrawal;Pain;Pain management;Pain Measurement;pain patient;pain relief;Pain Threshold;Pathway interactions;patient subsets;Patients;Persons;Pharmaceutical Preparations;Physiological;Population;preclinical study;prescription opioid;Provider;psychologic;response;Role;secondary outcome;Secondary to;Series;Severities;Site;Sparrows;Specialist;Substance Withdrawal Syndrome;success;System;Testing;Therapeutic;therapeutic opioid;treatment optimization;Trigeminal nerve structure;Trigeminal System;vagus nerve stimulation;wearable device;Withdrawal Symptom

PROJECT_TITLE: Understanding the Mechanistic, Neurophysiological, and Antinociceptive Effects of Transcutaneous Auricular Neurostimulation for Treatment of Chronic Pain


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biotechnology;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Genetics;Human Genome;Immunization;Mental Health;Microbiome;Prevention;Vaccine Related

PI_NAMEs: FORTINSKY, RICHARD H (contact)

PROJECT_TERMS: African American;Aging;Agreement;American;Applied Genetics;Basic Science;Behavior;Behavior Therapy;Biological Markers;biomarker discovery;biomarker validation;Biometry;Capsicum;causal model;Cells;Clinic;Clinical Trials;Cognition;Cognitive;cohort;Collaborations;Computer software;Conduct Clinical Trials;COVID-19 pandemic;Data;Data Analyses;data exchange;Data Pooling;data resource;Data Security;data standards;Database Management Systems;Databases;Detection;Development;Devices;disability;Discipline;early detection biomarkers;education research;Elderly;Enrollment;Ensure;Epidemiologic Methods;epidemiology study;experience;frailty;Funding;Gait;Generations;Genetic;Genomic medicine;genomic profiling;Genomics;geriatric depression;Geriatrics;Gerontology;Goals;Growth;hands-on learning;Health;Heterogeneity;Host Defense;Impaired cognition;improved;Individual;influenza virus vaccine;innovation;Intervention;Knowledge;Laboratories;late life;Learning;Link;longitudinal analysis;Longitudinal Studies;Measurement;Measures;Mediation;Mendelian randomization;Mental Depression;Metformin;microbiome analysis;microbiome research;Mission;Molecular;next generation sequencing;older adult;Older Population;Online Systems;operation;Outcome;Participant;Peripheral Blood Mononuclear Cell;Phenotype;Physical Function;Pilot Projects;population based;Population Study;Productivity;recruit;Regulation;Reproducibility;Research;Research Design;Research Personnel;Research Support;Resolution;Resources;Science;Scientist;Secure;senescence;Services;single-cell RNA sequencing;Source;standardize measure;Techniques;The Jackson Laboratory;United States National Institutes of Health;vaccine response;vaccine trial;Work

PROJECT_TITLE: Data Core RC2


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome

PHR: RC3 Project Narrative The RC3 Biomarkers and Preclinical Core will provide investigators (UConn OAIC scholars, developmental and pilot project investigators and the broader scientific community) with expertise needed to interrogate drivers of aging in humans and animal models related to diseases of aging and disability in order to further their studies of precision gerontology. The Core will assist investigators in development of protocols, facilitate interactions between investigators and established UConn and Jackson Laboratory for Genomic Medicine cores and facilitate data analysis and biomarker discover in conjunction with RC2 Data Resource Core.

PI_NAMEs: HAYNES, LAURA  (contact)

PROJECT_TERMS: Address;Adoption;African American;Aging;aging biomarker;aging related disease;American;Animal Model;Behavior Therapy;bench to bedside;biobank;Biological;Biological Aging;Biological Assay;biological heterogeneity;Biological Markers;biomarker discovery;biomarker identification;Capsicum;Chronic Disease;Clinical Trials;cohort;Communities;Core Facility;COVID-19 pandemic;Data Analyses;Data Collection;data resource;data streams;Databases;Development;disability;drivers of aging;Ensure;experience;Experimental Designs;Familiarity;frailty;functional outcomes;Funding;Future;Genomic medicine;Genomics;Gerontology;Goals;Health;Heterogeneity;Human;human model;human subject;immune function;Immunology;improved;Individual;infectious disease model;Intervention;Laboratories;late life;Lead;Major Depressive Disorder;Measurement;Metabolism;metabolomics;Methods;Molecular;Mus;novel;older adult;Online Systems;Outcome;Participant;Peripheral Blood Mononuclear Cell;Phenotype;Physical Function;Pilot Projects;Postdoctoral Fellow;pre-clinical;Pre-Clinical Model;professor;protocol development;Protocols documentation;Research;Research Personnel;Research Support;resilience;Resources;Sampling;Scientist;Services;single-cell RNA sequencing;Specialist;specific biomarkers;success;Systems Biology;Techniques;Technology;The Jackson Laboratory;Tissues;tool;transcriptomics;Translations;Validation;Work

PROJECT_TITLE: Biomarkers Core RC3


NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Neurosciences;Regenerative Medicine;Rehabilitation;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stroke

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project Narrative Stroke can cause permanent learning, memory, and motor deficits. Adult neural stem cells have the capacity to home to the brain injury and are thought to be an important part of the repair process after stroke. This proposal aims to gain a better understanding of processes that influence adult neural stem cells following stroke and to identify future strategies to increase brain repair following stroke.

PI_NAMEs: SAYRE, NAOMI LEDENE (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Ablation;Acute;Address;Adult;Affect;Animals;Automobile Driving;Brain;Brain Injuries;brain repair;burden of illness;C-terminal;Cell Differentiation process;Cell membrane;cell motility;Cell Nucleus;Cells;chemokine receptor;chromatin immunoprecipitation;Clinical;Cues;Data;Defect;deprivation;Disease;experience;extracellular;Finding by Cause;Functional impairment;Future;Genetic Transcription;Glucose;healing;Home;Impairment;improved;In Vitro;in vivo;insight;Intervention;Ischemia;ischemic lesion;Ischemic Stroke;Knock-out;Knockout Mice;Laboratories;LDL-Receptor Related Protein 1;Learning;Lesion;Ligands;Lipoprotein Receptor;Long term disability;Malignant Neoplasms;Measures;Mediating;Membrane;Membrane Proteins;Memory impairment;Messenger RNA;Methods;Middle Cerebral Artery Occlusion;migration;Modeling;motor deficit;motor impairment;motor recovery;mouse model;Mus;nerve stem cell;nestin protein;neuroblast;Neuroglia;Neurologic;neuroprotection;new therapeutic target;news;novel;Oxygen;Pathway interactions;Patients;post stroke;Process;Production;Proliferating;Protein C;protein expression;Proteins;receptor;receptor binding;Recovery;red fluorescent protein;Regulation;repaired;Research;response;Role;self-renewal;Signal Transduction;Signaling Protein;Site;stem cell biology;stem cell function;stem cell migration;stem cell proliferation;stem cell survival;Stem cell transplant;Stroke;stroke outcome;stroke recovery;subventricular zone;Surgical Models;Survivors;Tertiary Protein Structure;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Time;Tissues;trafficking;transcription factor;Transcriptional Regulation;United States;Up-Regulation;virtual

PROJECT_TITLE: LRP1 as a novel regulator of CXCR4 in adult neural stem cells and post-stroke response

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Dental, Oral, and Craniofacial Disease;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: ORTHOPEDICS

PHR: Canonical Wnt signaling is used therapeutically to enhance bone formation, but the related mechanisms utilized by osteoprogenitors remain poorly understood. This project aims to identify and characterize the role(s) novel ligand-receptor combination of Rspondins and Lgrs, which modulate cWnt signaling. Compromised, non-healing fractures pose a significant public health problem; understanding the molecular drivers of osteogenesis already approved for therapy will help in developing new approaches to reduce the incidence of delayed union and nonunion in fracture healing of both long bones and the craniofacial region.

PI_NAMEs: HANKENSON, KURT DAVID;SANJAY, ARCHANA  (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: Address;Adult;Attenuated;Binding;BMP2 gene;bone;Bone callus;bone fracture repair;bone healing;Bone Injury;Bone Regeneration;bone repair;Calvaria;Cell Lineage;Cells;Chondrocytes;Clinical;craniofacial;Data;Defect;Development;Embryo;Family;Family member;Fracture;Genes;Goals;GPR4 gene;Hand;healing;Histology;In Vitro;in vivo;Incidence;Individual;injured;Injury;Knockout Mice;Leucine-Rich Repeat;Ligands;Limb Development;Limb structure;long bone;LoxP-flanked allele;Mechanics;Mesenchymal;Mesenchymal Stem Cells;Mesenchyme;microCT;Modeling;Molecular;Molecular Analysis;mouse model;mRNA Expression;Mus;novel;novel strategies;novel therapeutics;osteoblast differentiation;Osteoblasts;osteochondral tissue;Osteogenesis;osteogenic;osteoprogenitor cell;Pathway interactions;Periosteal Cell;Periosteum;Play;Positioning Attribute;prevent;Process;progenitor;Proliferating;Property;protein function;Proteins;Public Health;Publishing;receptor;Recombinants;regenerative therapy;Regulation;Reporter;Research;response;response to injury;Role;Signal Transduction;Site;Skeletal Development;skeletal stem cell;stem cell differentiation;stem cell self renewal;stem cells;Testing;Therapeutic Uses;Time;tissue regeneration;WNT Signaling Pathway

PROJECT_TITLE: Rspondin-Lgr Axis in Bone Regeneration

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Prevention

PHR: PROJECT NARRATIVE - PESC The UConn OAIC Pilot and Exploratory Studies Core (PESC) will promote the development of novel ideas and approaches to improving and sustaining independent function in older persons by funding up to 3 pilot and exploratory studies (PES) that support Precision Gerontology for each year of the award. Projects can include a range of study designs from basic bench and human subject research to population science, and each PES will be expected to generate preliminary data to better position investigators to achieve external funding. Ultimately, the PESC seeks to create a pipeline of independent investigators pursuing research that enhances our understanding of increased heterogeneity with aging and/or utilizes precise targeting to improve or sustain independence in older persons.

PI_NAMEs: BARRY, LISA C (contact)

PROJECT_TERMS: Address;Adult;African American;Aging;aging related;American;Applications Grants;Area;Award;Behavior Therapy;biomarker discovery;biomarker validation;blood-based biomarker;Capsicum;career;career development;clinical phenotype;Clinical Research;Clinical Trials;cohort;Collaborations;COVID-19 pandemic;Data;Data Analyses;Data Collection;Dedications;Department chair;Depressed mood;Development;disability;early detection biomarkers;Early identification;education research;Educational Intervention;Elderly;Electronic Mail;Ensure;experience;Faculty;Fostering;frailty;Functional disorder;Funding;Future;Generations;Geriatrics;Gerontology;Goals;Grant;Health;Heterogeneity;human subject;Human Subject Research;improved;innovation;Institutional Review Boards;Interdisciplinary Study;Journals;Knowledge;large datasets;Manuscripts;meetings;Mental Depression;Mental Health;Monitor;new technology;novel;nutrition;older adult;Older Population;Online Systems;Outcome;Peer Review;Performance;Physical activity;Physical Function;Pilot Projects;Population Sciences;Positioning Attribute;Process;Protocols documentation;Publishing;recruit;Request for Applications;Research;Research Design;Research Personnel;Research Support;Resources;Selection Criteria;Series;Specific qualifier value;success;Testing;United States National Institutes of Health;Universities;validation studies;web site;webinar

PROJECT_TITLE: Pilot and Exploratory Core PESC


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative: Tau PET imaging is an important tool to study aging and Alzheimer’s disease in research and to test the impact of therapeutics in clinical trials. However, different tau PET tracers have different affinity for tau aggregates and off-target signal profiles, making it difficult to compare results across studies using distinct tau tracers. We will compare cross-sectional and longitudinal tau measures obtained with the two most widely used tau PET tracers, [18F]Flortaucipir and [18F]MK6240, head-to-head in the same volunteers to elucidate the advantages and caveats of their use in research cohorts, clinical trials, and clinical practice.

PI_NAMEs: BAKER, SUZANNE L;PASCOAL, THARICK  (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Affinity;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer’s disease biomarker;Amyloid beta-Protein;Atrophic;Autopsy;Basal Ganglia;Benchmarking;Binding;Biological Assay;Biological Markers;Blood;Brain;Brain region;cerebral atrophy;Characteristics;clinical practice;Clinical Research;Clinical Trials;Cognition;Cognitive;cognitive testing;cohort;Communities;Data;Data Set;Dementia;Deposition;Development;Diagnostic;diagnostic accuracy;Disadvantaged;Disease Progression;drug testing;Elderly;Face;follow-up;Functional disorder;Generations;Goals;Head;imaging agent;improved;Individual;large scale data;longitudinal analysis;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Meninges;Methods;mild cognitive impairment;Monitor;MRI Scans;Natural History;Nerve Degeneration;Neurofibrillary Tangles;novel;Outcome;outcome disparities;Pathology;Patients;Pattern;Performance;Persons;Pharmaceutical Preparations;Phase;Plasma;Positron-Emission Tomography;programs;rate of change;Reporting;Research;research study;Sample Size;Scanning;Signal Transduction;Site;Staging;Standardization;Structure of choroid plexus;Surrogate Endpoint;tau aggregation;tau Proteins;tau-1;Testing;Therapeutic;Therapeutic Effect;Therapeutic Intervention;Time;tool;Tracer;uptake;volunteer;white matter

PROJECT_TITLE: Longitudinal multicenter head-to-head harmonization of tau PET tracers

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Contraception/Reproduction;Disability Research;Intellectual and Developmental Disabilities (IDD);Maternal Health;Pregnancy;Prevention;Women's Health Research

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE This research project will yield the first large-scale multi-state data on pregnancy-related information needs of women with developmental disabilities that affect cognition (DD-C), and will inform future communication of a range of health messages to people with DD-C. Our proposed decision aid will help women with DD-C assess their support needs in relation to pregnancy, time their pregnancies, prepare for a healthy pregnancy if they decide they are ready for pregnancy, and communicate with medical professionals about reproductive decisions. This project directly supports NICHD's vision of “Healthy pregnancies. Healthy children. Healthy and optimal lives.”

PI_NAMEs: HORNER-JOHNSON, WILLI  (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Address;Adult;adverse outcome;adverse pregnancy outcome;Affect;Child;Choice Behavior;Clinical;Clinical Trials;Cognition;Collaborations;Communication;Comprehension;Conflict (Psychology);Data;Decision Aid;Decision Making;design;Development;Developmental Disabilities;disability;Disadvantaged;efficacy testing;evidence base;experience;Face;financial decision making;Friends;Funding;Future;General Population;Goals;Health;Health behavior;Healthcare;healthy pregnancy;improved;Individual;innovation;Interview;Investigation;Knowledge;Libraries;Low Birth Weight Infant;Mammographic screening;Maternal and Child Health;maternal stress;Medical;Methods;motherhood;National Institute of Child Health and Human Development;Needs Assessment;novel;Operative Surgical Procedures;Outcome;Participant;Patient Participation;Patients;Pattern;peer;Persons;Planned Pregnancy;Population;Pre-Eclampsia;Preconception Care;Pregnancy;Pregnancy Outcome;pregnant;Premature Birth;Preparation;prevent;Process;Readiness;reproductive;Research;Research Project Grants;Resources;Risk;Sampling;Self Efficacy;smoking cessation;sociodemographic group;Subgroup;support tools;Surveys;Target Populations;Time;tool;tool development;Trust;unintended pregnancy;usability;Vision;web based decision aid;web interface;Woman;women with disabilities;women's outcomes;Work

PROJECT_TITLE: Understanding and Supporting Reproductive Decisions Among Women with Developmental Disabilities that Affect Cognition

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science

PI_NAMEs: STEFFENS, DAVID C. (contact)

PROJECT_TERMS: Address;Aging;American;Area;Assessment tool;Basic Science;behavior influence;Body System;Capsicum;career;career development;Clinical;Clinical Research;Clinical Trials;Collaborations;Communities;Competence;Counseling;Dedications;disability;Discipline;education research;Educational Activities;educational atmosphere;Educational Curriculum;Educational Status;Elderly;Environmental Risk Factor;Epidemiologist;Epidemiology;epidemiology study;Evaluation;experience;Exposure to;Faculty;Feedback;Financial Support;flexibility;Funding;Funding Agency;Generations;Genomic medicine;Geriatrics;Gerontology;Goals;Health;Health Services;Health Services Research;Human Subject Research;improved;Individual;Institution;interdisciplinary approach;Interdisciplinary Study;interest;Kinesiology;Laboratories;Leadership;Letters;medical schools;medical specialties;meetings;Mentors;Mid-Career Clinical Scientist Award (K24);Minority Groups;Molecular;Monitor;multidisciplinary;National Institute of Mental Health;neurobehavioral;Nutritional Science;Pharmacy facility;Physicians;Postdoctoral Fellow;Process;Productivity;professor;programs;Psychiatrist;Psychiatry;Psychologist;Public Health;recruit;Research;research and development;Research Personnel;Research Project Grants;Research Project Summaries;Research Training;Resources;School Nursing;Schools;Science;Scientist;Self Assessment;Services;skill acquisition;skills;social factors;Social Work;Source;Structure;Talents;Time;Training;Training Programs;Translational Research;Translations;Underrepresented Minority;United States National Institutes of Health;Vocational Guidance;Wages;Work

PROJECT_TITLE: Research Education Component


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Obesity;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Stomach Cancer

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE The proposed research to study germline CDH1 variants and obesity in Hispanic/Latino gastric cancer patients is relevant to public health because it may lead to the first discovery of a molecular cause for gastric cancer health disparities experienced by these patients. The expected results could guide genetic testing criteria and lifestyle recommendations that enable the prevention or early detection of gastric cancer. Thus, the proposal is relevant to the NIH's mission to reduce illness and lengthen life.

PI_NAMEs: WANG, SAM C. (contact)

PROGRAM_OFFICER_NAME: SHARMAN, ANU

PROJECT_TERMS: Accounting;Age;Automobile Driving;Behavior;Benign;Biological Assay;Biology;cancer health disparity;Cancer Patient;CDH1 gene;Cell Adhesion Molecules;Cell Line;Characteristics;clinical epidemiology;clinically actionable;cohort;Data;Development;Diagnosis;Diet;Diffuse gastric cancer;Disease;disease-causing mutation;Disparity;E-Cadherin;Early Diagnosis;early onset;Engraftment;Enrollment;Environmental Exposure;Epidemiology;Epidermal Growth Factor Receptor;exome sequencing;experience;Face;gastric organoids;gene environment interaction;Genetic;genetic testing;Genomics;Germ Lines;Growth;Guidelines;health difference;Helicobacter Infections;Heterogeneity;High Prevalence;high risk;Hispanic;In Vitro;in vitro Assay;in vivo;in vivo Model;Incidence;Inflammatory Response;Inherited;innovation;Latino;Latino Population;Life;Life Style;lifestyle factors;lifetime risk;Logistic Regressions;Loss of Heterozygosity;Malignant Neoplasms;malignant stomach neoplasm;Masks;Methods;Mission;Modeling;Modification;Molecular;multidisciplinary;Not Hispanic or Latino;novel;Obese Mice;obese patients;Obesity;Onset of illness;Organoids;Outcome;outcome disparities;participant enrollment;Pathogenicity;Pathway interactions;Patients;Penetrance;Phenotype;Population Heterogeneity;Prevalence;Prevention;protein expression;Public Health;Publishing;Recommendation;Registries;Research;Research Personnel;Risk;Role;Sampling;Screening for Gastric Cancer;Signal Transduction;Syndrome;System;Testing;Thinness;tool;Transgenic Mice;tumor;tumor growth;tumor-immune system interactions;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Determining the role of germline CDH1 variants in gastric cancer outcome disparities in Hispanic/Latino patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Y(55)R]


PHR: OVERALL NARRATIVE The NYULH MetNet Center will leverage the complementary expertise of the NYU Melanoma program investigators to build an in-depth transcriptional and cellular characterization of tumor-microenvironment interactions that dictate early dissemination, using novel clinically relevant mouse models and well-annotated patient biospecimens.

PI_NAMEs: HERNANDO, EVA  (contact);OSMAN, IMAN

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: Behavior;biomarker identification;cancer type;cell behavior;cell type;Cells;Clinical;clinically relevant;Collaborations;Complex;Computational Biology;computer framework;Data;Databases;Dermal;Development;Disease;Distant;draining lymph node;Environment;epigenetic regulation;Evolution;Financial Support;Frequencies;Genes;Genetic;Genetic Diseases;Genetic Transcription;Genetically Engineered Mouse;Heterogeneity;Human;Immune Evasion;Immune response;Immunologic Surveillance;improved;Infrastructure;innovation;Institution;Intercept;Knowledge;Link;lymph nodes;Malignant - descriptor;Malignant Neoplasms;Maps;Mediating;Melanoma;melanoma biomarkers;Melanoma patient;Metastatic Melanoma;Methods;millimeter;Modeling;Molecular;Molecular Evolution;mouse genetics;mouse model;multidisciplinary;Neoplasm Metastasis;neoplastic cell;new therapeutic target;Non-Malignant;novel;novel therapeutics;Organ;Output;participant enrollment;Patient Care;Patient-Focused Outcomes;Patients;permissiveness;Population;prevent;Productivity;programs;prospective;Recurrence;Research;Research Personnel;Resources;Risk;Sampling;Signal Transduction;single cell genomics;Site;Skin;stem cell biology;survival outcome;synergism;System;temporal measurement;Testing;Therapeutic;Therapeutic Intervention;Thick;Tissues;transcriptomics;tumor;tumor immunology;tumor microenvironment;tumor progression;Tumor stage;tumorigenic

PROJECT_TITLE: NYULH Metastasis Research Network Center (NYULH MetNet Center)


NIH_SPENDING_CATS: Cancer

PI_NAMEs: HERNANDO, EVA  (contact)

PROJECT_TERMS: Accounting;Award;Cancer Center;Cancer Center Support Grant;Cell Nucleus;Collaborations;Communication;community engagement;Community Outreach;cost effectiveness;data integration;disease model;Ensure;Evaluation;Federal Government;Fostering;Funding;geographic barrier;Goals;Health;Incidence;Infrastructure;Institution;Institutional Policy;Invaded;Leadership;Local Government;material transfer agreement;meetings;Melanoma;Monitor;Neoplasm Metastasis;New York;Occupational activity of managing finances;outreach;Patients;Pilot Projects;Policies;Primary Neoplasm;Process;programs;Progress Reports;quality assurance;Race;Reagent;Reporting;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Site;Solid Neoplasm;Strategic Planning;synergism;Thick;Travel;Underrepresented Minority;United States National Institutes of Health;Universities;Woman;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Skin Cancer

PROJECT_TERMS: Adjuvant Therapy;Animal Model;Anoikis;apoAI regulatory protein-1;Automobile Driving;Bar Codes;Behavior;Biology;cancer cell;Candidate Disease Gene;candidate identification;Cell model;Cells;Cessation of life;Classification;Clinical;Correlation Studies;Cutaneous Melanoma;Data;data integration;Dermal;Development;Diagnosis;Epigenetic Process;Evolution;Exhibits;Gene Expression Profile;Genetic;Genetic Engineering;Genetic Transcription;Genetically Engineered Mouse;Goals;Heterogeneity;high risk;Human;human disease;human model;Immunohistochemistry;improved;Individual;Information Dissemination;innovation;Invaded;Laboratories;Link;Maintenance;Malignant Neoplasms;melanocyte;Melanoma;Melanoma Cell;Melanoma patient;Mesenchymal;Metastatic Melanoma;metastatic process;migration;millimeter;Modeling;Molecular;Monitor;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;Neural Crest;novel;novel therapeutic intervention;Nuclear Receptors;Outcome;Output;Pathogenesis;Pathologic;patient prognosis;Patient-Focused Outcomes;Patients;Phenotype;Population;prevent;Primary Neoplasm;Prognostic Marker;programs;Property;prospective;Protein Isoforms;Reporting;Research;Research Project Grants;Resected;Resources;Risk;Sampling;screening;Signal Transduction;single-cell RNA sequencing;Site;Technology;Testing;Tissues;Transcript;Transcriptional Regulation;transcriptomics;treatment response;Tropism;tumor;tumor heterogeneity;Tumor stage;tumorigenesis;tumorigenic;Variant

PROJECT_TITLE: Project 1: Tumor Cell Intrinsic Determinants of Early Dissemination in Melanoma


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Despite universal recognition of a desperate need for effective disease modifying therapy for Alzheimer's disease (AD) there has been no successful development of such a drug, however, advances in AD therapeutic research have set the stage for effective treatment of sporadic AD at its preclinical (asymptomatic) stage. This will be the first study of its kind: a potentially synergistic combination approach to dramatically reducing amyloid from asymptomatic individuals on the AD spectrum. We believe this proposed trial will be the most powerful test to date of the amyloid therapeutic hypothesis; if correct, this approach could ultimately prevent the onset of AD symptoms.

PI_NAMEs: AISEN, PAUL S. (contact);JOHNSON, KEITH A.;SPERLING, REISA A.

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: Activities of Daily Living;Address;Alzheimer's Disease;Alzheimer's disease therapeutic;Alzheimer's disease therapy;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-42;Amyloid beta-Protein;amyloid peptide;Antibodies;arm;asymptomatic Alzheimer's disease;Atrophic;Award;beta secretase;beta-site APP cleaving enzyme 1;Binding;Biological Markers;Biometry;Blood;Brain;Cerebrospinal Fluid;Clinic;Clinical;Clinical assessments;clinical development;Clinical Trials;Cognition;Cognitive;cognitive function;Collaborations;Combined Modality Therapy;Committee Membership;computerized;cooperative study;Country;Data;data management;Dementia;design;Development;Disease;Disease Progression;drug development;effective therapy;efficacy evaluation;Enrollment;Epidemic;exosome;experience;Futility;Generations;high risk;Hippocampus;Image;Impaired cognition;improved;indexing;Individual;inhibitor;instrument;Intervention;Magnetic Resonance;Magnetic Resonance Imaging;Measures;Modification;Monitor;monomer;Neocortex;Nerve Degeneration;Neurobiology;neurofilament protein L;Neurons;Oral;Participant;Pathologic;Pathology;Pathway interactions;Patient Self-Report;Pharmaceutical Preparations;Pharmacologic Substance;Placebo Control;Placebos;Plasma;Positron-Emission Tomography;pre-clinical;pre-clinical therapy;prevent;Prevention;primary outcome;Randomized;Randomized, Controlled Trials;Regimen;Research Personnel;Safety;Sampling;secondary outcome;Senile Plaques;Site;success;Symptoms;tau Proteins;tau-1;Testing;Therapeutic;Therapeutic Agents;Therapeutic Research;Therapeutic Trials;Therapy trial;tool;Treatment Protocols;uptake;Ventricular;Work

PROJECT_TITLE: Combination anti-amyloid therapy for preclinical Alzheimer's disease


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: COLLEGE PARK

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: Project Narrative Antibodies are an important class of therapeutics for treating cancer, autoimune diseases, and infectious diseases. The proposed research aims to exploit glycoengineering to understand how antibody glycosylation modulates antibody’s effector functions and to use the knowledge gained to improve antibody’s therapeutic efficacy.

PI_NAMEs: WANG, LAI-XI  (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Address;Affect;Animals;Anti-Inflammatory Agents;Antibodies;Antibody Affinity;antibody conjugate;Antibody Therapy;antibody-dependent cell cytotoxicity;Antigens;Apoptosis;Autoimmune Diseases;Azides;Biological Assay;cancer therapy;Circulation;Communicable Diseases;Complement-Dependent Cytotoxicity;Coupled;Data;design;Development;Endoglycosidases;Engineering;Fc Receptor;Fluorides;Fucose;Fucosidase;genetic approach;Glycoengineering;Glycoproteins;glycosylation;Heterogeneity;Hydrolysis;immune function;Immunoglobulin G;Immunoglobulin M;Immunology;immunoregulation;improved;Knowledge;Lactobacillus casei;Malignant Neoplasms;Methods;Modification;mutant;novel;Pathway interactions;Polysaccharides;receptor;receptor binding;recruit;Research;Rhamnose;Role;sialylation;Site;structural determinants;Substrate Specificity;System;technology platform;Therapeutic;Therapeutic antibodies;Treatment Efficacy

PROJECT_TITLE: Glycoengineering of antibodies to modulate immune functions

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PI_NAMEs: ITO, MAYUMI  (contact)

PROJECT_TERMS: Address;Adjuvant Therapy;ATAC-seq;Behavior;Benign;cancer cell;Cancer Control;cancer type;Cancerous;Cell Communication;Cell Lineage;cell type;Cells;Characteristics;chemokine;ChIP-seq;Chromatin;Clinical;Clinical Data;clinically relevant;Congenic Mice;cytokine;Cytokine Signaling;Data;Dermis;Development;Diagnosis;differential expression;Disease;Disseminated Malignant Neoplasm;Distal;draining lymph node;Environment;Epidermis;Epigenetic Process;Extracellular Matrix;Fibroblasts;Gene Cluster;Genes;Genetic Engineering;genetic manipulation;Genetic Transcription;Growth;Growth Factor;Heterogeneity;Histones;Human;Human Pathology;IGF1 gene;IGF1R gene;Immune;Immune system;Immunofluorescence Microscopy;Immunohistochemistry;in vivo;insight;Invaded;Ligands;Link;Lymphatic;Malignant Neoplasms;Maps;melanocyte;Melanoma;Melanoma Cell;Melanoma patient;Metastatic Melanoma;Metastatic Neoplasm to Lymph Nodes;metastatic process;migration;Modeling;Molecular;molecular marker;morphogens;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;Organ;pancreatic cancer model;Pathologic;Pathway Analysis;Pathway interactions;Patient Selection;Patients;Pattern;Phenotype;Play;Population;prevent;Primary Neoplasm;Process;Prognostic Marker;prognostic value;programs;receptor;Regulation;Regulatory Element;Research;Resolution;Resources;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Solid Neoplasm;Spatial Distribution;Specimen;stem cells;Stromal Cells;synergism;targeted treatment;Technology;Testing;therapeutic target;Time;Tissues;Tomatoes;tool;transcription factor;transcriptome;transcriptomics;tumor;tumor heterogeneity;tumor initiation;tumor progression;tumorigenesis

PROJECT_TITLE: Project 2: Contribution of the Stromal Microenvironment to Early Dissemination


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Mental Illness;Neurosciences

ORG_CITY: PHILADELPHIA

PHR: Project narrative A single dose of the dissociative anesthetic nitrous oxide produces rapid and durable improvements in depressive symptoms that persist in otherwise treatment-resistant patients. The driving hypothesis of this proposal is that nitrous oxide induces distinct changes in neuronal activity on the time scale of minutes during administration, and engages neuroplastic mechanisms, over hours to days, that are mechanistically linked to long-lasting therapeutic effects. This project will use in vivo imaging techniques to investigate the action of nitrous oxide at the level of neurons and their neuronal connections over the natural trajectory of treatment and post- treatment in individual animals to better define the novel forms of neuroplasticity underlie the long-standing therapeutic effects.

PI_NAMEs: CICHON, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Acute;Aftercare;Anesthetics;Animal Model;Animals;antagonist;anti-depressive agents;Automobile Driving;Behavioral;Brain region;Calcium;Chronic stress;clinical effect;clinical practice;Clinical Research;depressive symptoms;disability;Dissociative Anesthetics;Dose;Electrophysiology (science);Foundations;Goals;hippocampal pyramidal neuron;Hour;Image;Imaging Techniques;improved;in vivo imaging;Individual;Inhalation;innovation;Intervention;Intravenous;Ketamine;Link;Mediating;Mental Depression;Mission;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;National Institute of General Medical Sciences;Neocortex;Neuronal Plasticity;Neurons;neuropsychiatric disorder;Nitrous Oxide;novel;Patients;pharmacologic;Refractory;Resistance;Rodent Model;stem;Structure;Synapses;Techniques;Testing;Therapeutic;Therapeutic Effect;Time;Work

PROJECT_TITLE: Cellular and circuit mechanisms of the therapeutic action of inhaled nitrous oxide in rodent models of chronic stress

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(55)R]


NIH_SPENDING_CATS: Cancer;Clinical Research;Immunotherapy;Lymphatic Research;Precision Medicine;Skin Cancer

PI_NAMEs: LUND, AMANDA W. (contact)

PROJECT_TERMS: Archives;Automobile Driving;Biological Markers;Biology;Biopsy;cancer cell;Cell Line;Cells;Clinical;clinical care;Clinical Management;clinically relevant;cohort;Complex;computational pipelines;computerized tools;Critical Pathways;Data;Diagnostic Neoplasm Staging;Disease;Disease Outcome;Distant;Distant Metastasis;draining lymph node;Education;Electronic Medical Records and Genomics Network;Event;Evolution;Excision;Exhibits;experimental study;Freezing;Generations;Goals;high dimensionality;Human;Image;Immune;Immunity;Immunologic Markers;Immunologic Surveillance;Immunologics;Immunosuppression;improved;innovation;interest;Interferon Type I;Interferons;Investigation;Knockout Mice;Knowledge;liquid crystal polymer;Localized Disease;Lymph;Lymph Node Dissections;Lymph Node Subcapsular Sinus;Lymph Node Tissue;lymph nodes;Lymphatic Endothelial Cells;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;Melanoma;melanoma biomarkers;Melanoma Cell;Melanoma patient;melanomagenesis;Metastatic Melanoma;Metastatic Neoplasm to Lymph Nodes;Modeling;Molecular;mouse model;multiplexed imaging;Mus;Neighborhoods;Neoplasm Metastasis;neoplastic cell;novel;Operative Surgical Procedures;Organ;Outcome;outcome disparities;Patient risk;patient stratification;patient subsets;Patient-Focused Outcomes;Patients;permissiveness;personalized strategies;Phenotype;prognostic;programs;Recurrence;Regional Disease;Research;Research Personnel;Resources;Rest;Retrospective cohort;risk stratification;Role;Sentinel Lymph Node;Signal Transduction;single-cell RNA sequencing;Site;Solid Neoplasm;spatial integration;Staging;Systemic disease;Testing;Time;Tissues;transcriptomics;treatment response;tumor;Tumor Biology;Tumor Immunity;tumor immunology;tumor initiation;tumor progression;tumor-immune system interactions;Validation;Work

PROJECT_TITLE: Project 3: The Evolving Role of Regional Lymph Nodes in Melanoma Progression


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Brain Disorders;Clinical Research;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: LA JOLLA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Autism spectrum disorder (ASD) is heterogeneous in its etiology and clinically complex but shared molecular mechanisms have not been systematically identified in cellular disease models. Here we identify single-cell, translation-level gene expression signatures in our unique resource of brain organoids derived from genome- engineered induced pluripotent stem cells that represent over a dozen genetic forms of ASD. If successful, our results will critically accelerate the development of a unified framework that enables molecular categorization of both genetic and idiopathic cases, facilitating the identification of biomarkers and the development of targeted therapies.

PI_NAMEs: AIGNER, STEFAN ;YEO, EUGENE WEI-MING (contact)

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Affect;apoB mRNA editing catalytic subunit;Architecture;autism spectrum disorder;Autopsy;Awareness;Biological Assay;biomarker discovery;biomarker identification;Brain;brain tissue;Calcium;candidate validation;Categories;Cell Line;Cell model;cell type;Cells;Child;Chromium;Chromosome Mapping;Clinical;Complex;Copy Number Polymorphism;Corpus striatum structure;Data;Data Set;Defect;Development;diagnostic biomarker;diagnostic development;disease model;disorder risk;drug testing;Enzymes;Etiology;FRAP1 gene;Frequencies;functional outcomes;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Models;Genetic Transcription;Genome;Genome engineering;Human;human induced pluripotent stem cells;Image;Individual;induced pluripotent stem cell;insight;Interneurons;Investigation;Measures;Messenger RNA;Methodology;Methods;microdeletion;migration;model of autism spectrum disorder;Modeling;Molecular;multi-electrode arrays;Nature;Neurodevelopmental Disorder;neuronal circuitry;Neurons;Noise;Operative Surgical Procedures;Organoids;Pathologic;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;Patients;pharmacologic;Phenotype;Population;predictive signature;Prosencephalon;Protein Biosynthesis;Proteins;rabies viral tracing;Recurrence;Regulation;Reproducibility;Research Personnel;Resolution;Resources;Ribosomal Interaction;Ribosomal Proteins;Ribosomes;risk variant;RNA Editing;Role;Series;Signal Transduction;single-cell RNA sequencing;Sirolimus;Site;stable cell line;stem cell model;stem cells;Synapses;targeted treatment;Testing;therapeutic development;Tissues;tool;transcriptome;transcriptomics;transgene expression;Translations;translatome;Variant

PROJECT_TITLE: Human Isogenic Organoid Models of Genetic Forms of Autism to Identify Convergent and Divergent Pathomechanisms in Autism

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]