ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Chronic Pain;Endocannabinoid System Research;Neurosciences;Pain Research;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE The lifetime prevalence of alcohol use disorders (AUDs) is ~30% in the U.S. population, and is significantly higher in some subpopulations including those with chronic pain. While the analgesic and anesthetic properties of alcohol are well known, as is the fact that alcohol withdrawal causes hyperalgesic states that can drive negative reinforcement driven alcohol consumption in some patients. We will determine the mechanisms by which endogenous cannabinoids regulate withdrawal-associated hyperalgesia and examine therapeutic potential of endocannabinoid modulation for alcohol-pain co-morbidity.

PI_NAMEs: PATEL, SACHIN  (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: 2-arachidonylglycerol;Abstinence;Affect;alcohol abuse therapy;Alcohol consumption;alcohol effect;alcohol relapse;alcohol use disorder;Alcohol withdrawal syndrome;Alcoholic Intoxication;Alcohols;Amygdaloid structure;Analgesics;Anesthetics;Anxiety;Award;Behavior;Biological Assay;Biological Models;Calcium;cannabinoid receptor;Cannabis;cell cortex;Characteristics;chronic alcohol ingestion;chronic pain;CNR1 gene;CNR2 gene;comorbidity;Data;depressive symptoms;Disinhibition;Dose;Electrophysiology (science);endocannabinoid signaling;Endocannabinoids;endogenous cannabinoid system;Environment;Enzymes;Functional disorder;Funding;gamma-Aminobutyric Acid;Glutamates;Hyperalgesia;Hypersensitivity;Image;in vivo;in vivo calcium imaging;Individual;insight;Insula of Reil;Interneurons;Investigation;Label;Ligands;Link;lipoprotein lipase;MAGL inhibitor;Mechanical Stimulation;Mechanics;Mediating;Medical;midbrain central gray substance;Modeling;Monoacylglycerol Lipases;Motivation;mouse model;Mus;negative affect;Negative Reinforcements;neural circuit;neurobiological mechanism;neuromechanism;Neurons;Nociceptive Stimulus;novel;novel strategies;optogenetics;Pain;Pain Disorder;pain processing;Pain Threshold;Pathway interactions;Patients;pharmacologic;Phenotype;Physiological;Population;pre-clinical;preclinical efficacy;Preclinical Testing;Prefrontal Cortex;Prevalence;prevent;Process;Prognosis;Property;Regulation;Relapse;Role;sciatic nerve injury;Sensory;Signal Transduction;Synapses;System;Testing;Therapeutic;transmission process;Validation;Viral;Withdrawal

PROJECT_TITLE: Endocannabinoid Mechanisms in the Pathophysiology of Alcohol Use Disorders

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: ROCHESTER

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Cigarette smoking prevalence is highest among American Indian and Alaska Native (ANAI) people in Alaska, which results in persistence of many health disparities. The goal of this study is to evaluate the effectiveness of a culturally-adapted, ANAI family-based incentives intervention for smoking cessation. The study will also explore the potential for adoption and sustainability of the intervention within the Alaska Tribal Health System.

PI_NAMEs: PATTEN, CHRISTI A (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: addiction;Adopted;Adoption;Adult;Alaska;Alaska Native;Alaska Native population;American Indian community;American Indian Population;American Indians;behavioral economics;Biochemical;Cardiovascular system;Cellular Phone;cigarette smoking;Climate;collaborative approach;Communities;comparison intervention;Cost Effectiveness Analysis;COVID-19 pandemic;cultural values;Data;Decision Making;design;digital;Dissemination and Implementation;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;Enrollment;evidence base;Exposure to;Family;Family member;family support;financial incentive;frontier;Future;future pandemic;Geography;Goals;group intervention;Health;health disparity;health organization;Health Services Accessibility;Health system;Home;Household;hybrid type 1 design;incentive-based intervention;Incentives;indexing;Individual;Intervention;intervention effect;Interview;Life Style;Literature;Maintenance;Malignant neoplasm of lung;Measures;Mediator;Morbidity - disease rate;mortality;Native-Born;non-Native;Odds Ratio;Participant;Patient Recruitments;Persons;Policies;Population;post intervention;Pregnant Women;Process;programs;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;residence;Resources;respiratory;Rewards;Role;Rural;sex;Smoke;Smoking;smoking abstinence;smoking cessation;Smoking Cessation Intervention;smoking prevalence;Smoking Status;Social Distance;social media;Social support;System;Telephone;Testing;theories;therapy design;Time;Tobacco;trial enrollment;tribal health;Tribes;urban area;urban residence;virtual intervention;Work

PROJECT_TITLE: Alaska Native Family-Based, Financial Incentives Intervention for Smoking Cessation: an RCT

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-V(55)]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Kidney Disease

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Despite the immense health burden of chronic kidney disease, effective treatment options remain limited. A distinct proximal tubule subpopulation may drive chronic kidney disease progression, so a better understanding of the formation of this subpopulation may lead to clinical breakthroughs. This project aims to identify regulatory elements mediating proximal tubule state transitions that may be therapeutically targetable.

PI_NAMEs: LEDRU, NICOLAS HYUN (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;Address;Adult;Affect;Aging;American;Area;ATAC-seq;Back;Binding;Bioinformatics;Black, Indigenous, People of Color;burden of illness;candidate identification;career;Cell Culture Techniques;Cell Nucleus;cell type;Cells;Characteristics;Chromatin;Chronic;Chronic Kidney Failure;Clinical;collaborative environment;computerized tools;Data Set;Development;Dialysis procedure;Disease;Disease Outcome;Disease Progression;educational atmosphere;effective therapy;End stage renal failure;Environment;Epigenetic Process;experience;Fibrosis;Financial Hardship;Gene Expression Profile;gene regulatory network;Generations;Genes;Genetic;Genetic Transcription;Goals;Health;health disparity;Healthcare;Heterogeneity;Human;improved;In Vitro;Incentives;Individual;Inflammatory;injury and repair;Injury to Kidney;insight;Kidney;Kidney Diseases;Kidney Transplantation;Knowledge;Laboratories;Learning;Libraries;Life;Maintenance;Mediating;Medical;Modeling;multimodality;Multiomic Data;multiple omics;network models;Nucleic Acid Regulatory Sequences;Organ;Outcome;patient population;Patients;Persons;Phenotype;Physicians;Population;Prevalence;Profibrotic signal;Recovery;Regulatory Element;Renal function;Renal Replacement Therapy;repaired;Research;Resolution;risk variant;Role;Sampling;Scientist;Signal Transduction;single cell sequencing;single nucleus RNA-sequencing;single-cell RNA sequencing;Techniques;Therapeutic;therapeutic candidate;Therapeutically Targetable;Training;transcription factor;transcriptome;transcriptomics;treatment strategy;Update;Validation;Work

PROJECT_TITLE: The gene regulatory landscape of healthy and failed repair proximal tubule subpopulations in kidney disease


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHAMPAIGN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: NARRATIVE Genome editing technologies provide novel opportunities to advance basic research and treat human diseases but approaches that use active nucleases to edit DNA can induce undesired and deleterious effects in the genome, which can reduce their therapeutic potential. Prime editors are a recently emerged gene-editing variant capable of introducing precise modifications to DNA, with minimal damage to the genome. This proposal is focused on creating an integrative prime editing toolkit that will provide investigators with technologies that will enable their use in vivo, improve their specificity and streamline their design and implementation, thereby advancing the applications of this methodology in biotechnology and biomedicine.

PI_NAMEs: PEREZ-PINERA, PABLO  (contact);SONG, JUN S

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: adeno-associated viral vector;adenovirus mediated delivery;Amyotrophic Lateral Sclerosis;base;base editor;Basic Science;Biological;biophysical techniques;Biotechnology;Carrying Capacities;cell type;Cells;Chromosomal translocation;Clinical Research;Clinical Trials;Computational Biology;computational suite;CRISPR/Cas technology;Cultured Cells;Data;delivery vehicle;design;Development;DNA;DNA Double Strand Break;DNA Sequence;Elements;Engineering;Evaluation;experience;Experimental Designs;experimental study;flexibility;Future;Gene Delivery;Gene Modified;gene therapy;Genes;Genome;genome editing;Genomic approach;Genomic DNA;human disease;Immune response;immunogenic;improved;in vivo;innovation;insertion/deletion mutation;intein;Knowledge;Machine Learning;Mediating;Methodology;Methods;miniaturize;Modification;multidisciplinary;Mutation;Nonsense Mutation;novel;nuclease;Open Reading Frames;Outcome;particle;Pathogenicity;Peptide Signal Sequences;Positioning Attribute;postmitotic;predictive modeling;prevent;prime editing;prime editor;promoter;reconstitution;Regulatory Element;Research;Research Personnel;response;Role;Site;Site-Directed Mutagenesis;Specificity;success;System;Technology;technology development;technology research and development;Testing;Therapeutic;Time;Tissues;tool;Trans-Splicing;Variant

PROJECT_TITLE: Development of Technologies for Efficient In Vivo Prime Editing

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Substance Misuse

ORG_CITY: COLLEGE PARK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: PUBLIC HEALTH SIGNIFICANCE Alcohol misuse imposes a staggering burden on public health and the global economy. While the root causes of alcohol misuse are complex and heterogeneous, there is ample evidence that many individuals use alcohol to dampen excess anxiety (‘self-medicate’). This study will harness an innovative combination of computational, brain imaging, and smartphone technologies to understand the chain of neurobiological and psychological factors that govern anxiety-fueled alcohol misuse, paving the way for developing more precise and effective treatment strategies for this debilitating illness.

PI_NAMEs: SHACKMAN, ALEXANDER JOSEPH (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: addiction;Address;Adult;Alcohol abuse;Alcohol consumption;alcohol craving;alcohol misuse;Alcohol Phenotype;Alcohols;Amygdaloid structure;Animal Model;Animals;Anterior;Anti-Anxiety Agents;Anxiety;Arousal;Behavior;Biological;Biological Psychiatry;Black, Indigenous, People of Color;Brain;brain based;Brain imaging;Brain region;Categories;Cell Nucleus;Cellular Phone;Clinical;clinically relevant;Communities;Complex;Computer Models;Consumption;coping;Coupling;craving;Data;data streams;design;Development;Diagnosis;digital intervention;Dimensions;Disease;disease classification;Distal;Distress;drinking;Ecological momentary assessment;effective therapy;Etiology;excessive anxiety;Feeling;Functional Magnetic Resonance Imaging;Goals;Human;imaging study;Individual;innovation;insight;Insula of Reil;interest;Life;Link;Maryland;Measures;Modeling;Morbidity - disease rate;mortality;National Institute on Alcohol Abuse and Alcoholism;Negative Reinforcements;neural;Neurobiology;neuroeconomics;neuroimaging;novel;Pathway interactions;Perception;Phenotype;Play;pre-clinical;Precision therapeutics;Premature Mortality;Probability;Psychiatric Diagnosis;Psychiatry;Psychological Factors;Psychophysiology;psychosocial;Public Health;racial diversity;recruit;Research;Risk;Role;Sampling;Severities;Structure of terminal stria nuclei of preoptic region;Symptoms;targeted treatment;Technology;Testing;theories;Therapeutic;therapeutic development;tool;trait;translational model;treatment strategy;Uncertainty;Undifferentiated;Variant;Work

PROJECT_TITLE: Using Computational Neuroimaging and Extended Smartphone Assessment to Understand the Pathways Linking Threat-Related Brain Circuits to Alcohol Misuse Across Adulthood

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: NEW YORK

ORG_NAME: VA  MEDICAL CENTER

ORG_STATE: NY

PHR: Individuals with lower extremity amputation are often challenged by complications that arise from poor prosthetic fit, including movement of the residual limb in the socket, known as pistoning. Pistoning can lead to gait instability, skin problems, and pain. Different prosthetic suspension systems have been developed to decrease this motion, including elevated vacuum suspension, which utilizes a pump to draw air from the socket. However, scientific analyses to understand the movement between the limb and socket in elevated vacuum systems have yet to be performed with a high level of accuracy. This study will use a state-of-the art imaging technique, known as dynamic stereo x-ray, to quantify the 3D movement of the residual limb in the socket. This information is critical for advancing prosthetic treatments to reduce secondary conditions and degenerative changes that result from poor prosthetic fit.

PI_NAMEs: MAIKOS, JASON  (contact)

PROJECT_TERMS: 3-Dimensional;Acclimatization;Address;Affect;Air;Algorithms;Amputation;analytical tool;Biomechanics;bone;brass;Cadaver;clinical practice;Clinical Trials;comorbidity;Complex;Computer software;Data;Development;digital imaging;Distal;evidence base;experience;Freedom;Future;Gait;Goals;Guidelines;Image;Imaging Techniques;Imaging technology;improved;in vivo;Individual;Investigation;kinematics;Limb structure;Lower Extremity;Measurement;Measures;Mechanics;Methodology;Methods;millimeter;Motion;Movement;Pain;Performance;Phase;Positioning Attribute;Process;Prosthesis;Prosthesis Design;prosthesis fitting;prosthetic socket;Protocols documentation;Pump;Radio-Opaque;Research Personnel;residual limb;Residual state;Roentgen Rays;Rotation;Sampling;Secure;skeletal;skeletal movement;Skin;socket design;soft tissue;Speed;Suction;Surface;Suspensions;System;Techniques;Testing;three-dimensional modeling;tibia;Time;Tissues;Translations;transmission process;treadmill;Universities;Vacuum;Validation;Walking;X-Ray Computed Tomography

PROJECT_TITLE: Quantifying Bone and Skin Movement in the Residual Limb-Socket Interface of Individuals with Transtibial Amputation Using Dynamic Stereo X-Ray

STUDY_SECTION_NAME: Rehabilitation Engineering & Prosthetics/Orthotics [RRD5]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Diabetes;Genetics;Nutrition;Obesity;Pain Research;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: Nashville

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: NARRATIVE Degenerative rotator cuff injury is one of the leading causes of decreased functional capability of the upper body and increasing evidence suggests that intrinsic tendinous changes, such as those consistent with diabetes and obesity, promote development of degenerative tears. Although diabetes and obesity are among the most common, and rapidly increasing, chronic conditions, their impact on musculoskeletal health is largely understudied. This work directly contributes to understanding whether observed links between diabetes, obesity and degenerative tears of the cuff are merely associational, or causal; and such knowledge can guide strategies in prevention and management of this debilitating condition.

PI_NAMEs: HERZBERG, SIMONE  (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Academic Medical Centers;Address;Affect;Aging;algorithm development;Algorithms;Anatomy;Belief;biobank;Body mass index;career;case control;Cell Death;Chronic;chronic pain;Classification;clinical investigation;Code;Cross-Sectional Studies;Data;Databases;design;Development;Diabetes Mellitus;Diagnostic;Disease;disease phenotype;DNA;Electronic Health Record;Epidemiologic Methods;Epidemiologist;epidemiology study;Etiology;fasting glucose;Fatty acid glycerol esters;Fiber;flexibility;Foundations;Future;Genetic;genetic association;Genetic Predisposition to Disease;genetic variant;Genetic Variation;genome wide association study;Health;Heterogeneity;High Prevalence;improved;Individual;Infiltration;Injury;Institution;instrument;Insulin;International;Knowledge;Link;Literature;Measures;Mediating;Mediation;Mendelian randomization;Meta-Analysis;Methods;Modeling;Morbidity - disease rate;Muscular Atrophy;Musculoskeletal;Musculoskeletal Diseases;musculoskeletal injury;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Natural Language Processing;Nervous System Trauma;novel;Nutrient;Obesity;Observational Study;Outcome;Pain;Participant;Patients;Persons;Phenotype;Physicians;Population;Population Control;precision medicine;Prevalence;Prevention;Prospective cohort;Publishing;repository;Research;Research Design;Risk;Risk Factors;risk mitigation;Role;Rotator Cuff;rotator cuff injury;rotator cuff tear;Sampling;Scientist;Shoulder Pain;skills;Source;Structure;systematic review;Techniques;Tendinopathy;Tendon structure;Testing;theories;Training;trait;Trauma;vascular injury;Waist-Hip Ratio;Work

PROJECT_TITLE: Investigating Causal Relationships of Diabetes and Obesity on Degenerative Rotator Cuff Tear

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-L(20)L]


FUNDING_MECHANISM: OTHERS

ORG_CITY: SALEM

ORG_NAME: SALEM VA MEDICAL CENTER

ORG_STATE: VA

PHR: The term "Overlap Syndrome" (OS) is used to describe the presence of both chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) in a single patient. Veterans with OS who also have excessive daytime sleepiness (EDS) are at highest risk for functional decline yet have the greatest barriers to exercise training. Thus, there is a critical need to identify novel exercise strategies that meet the individual needs and capacities of Veterans with EDS-OS. We propose to test moderate intensity interval training (MIIT), a novel exercise intervention whose translation into durable lifestyle change may be facilitated by the feasibility of short bouts of increased PA. Our proposal addresses key knowledge gaps in rehabilitation research by investigating the clinical phenotype of EDS-OS to determine the association with functional outcomes and response to a novel exercise intervention with the goal to reduce functional decline. Results will inform a larger exercise trial and Merit application that will facilitate my career goal to be an independent scientist in exercise rehabilitation in OS.

PI_NAMEs: MACREA, MADALINA  (contact)

PROJECT_TERMS: Accelerometer;Address;Behavioral;behavioral study;C-reactive protein;cardiorespiratory fitness;cardiovascular health;career;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Classification;clinical phenotype;common symptom;Complex;Continuous Positive Airway Pressure;Data;design;disability;Disease;Drowsiness;Dyspnea;Economic Burden;Educational Intervention;Endothelium;Excessive Daytime Sleepiness;Exercise;exercise intervention;exercise rehabilitation;exercise training;Exhibits;Experimental Designs;Feedback;functional decline;functional outcomes;functional status;Future;General Population;Glucose;Goals;Health;Health Benefit;healthy lifestyle;high risk;Home;implementation barriers;improved;Individual;International;Interval training;Knowledge;Life;Life Style;Lipids;Literature;Lung Diseases;Measures;Mediating;Morbidity - disease rate;mortality;novel;Obstructive Sleep Apnea;optimal treatments;Outcome;patient population;Patients;Phenotype;Physical activity;Pilot Projects;preference;Premature aging syndrome;Psyche structure;Quality of life;randomized trial;rehabilitation research;Reporting;response;Risk;Scientist;Self Efficacy;Serum;SF-36;standard of care;Surveys;Syndrome;Techniques;Testing;Training;translational barrier;Translations;treatment as usual;validation studies;Veterans

PROJECT_TITLE: The Effect of Interval Exercise on Functional Outcomes in Veterans with COPD and OSA

STUDY_SECTION_NAME: Career Development Program - Panel II[RRD9]


NIH_SPENDING_CATS: Complementary and Integrative Health;Digestive Diseases;Genetics;Human Genome;Microbiome;Neurosciences;Nutrition;Prevention

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE This project investigates the role of the early life gut microbiota in the development of enteric neurons within the gastrointestinal (GI) tract, which form the physiological basis for GI motility. Motility disorders such as irritable bowel syndrome (IBS) are chronic, costly conditions for which neither cause nor cure is currently known. Through the proposed studies, we expect to gain insights into the fundamental significance of environmental disturbances during development, and the relevance of such disturbances for GI health.

PI_NAMEs: FRITH, MARY  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: 16S ribosomal RNA sequencing;Adult;Affect;Age;American;Animal Experimentation;Animal Model;Animals;Antibiotics;ATAC-seq;Biological Assay;Butyrates;cell type;Cells;Chicago;Childhood;Chronic;Clinic;Clinical;Colon;comparative;cost;Coupled;critical period;Data;data integration;Development;Diagnosis;Diet;Digestive System Disorders;dysbiosis;effective therapy;Enteral;Enteric Nervous System;epigenetic regulation;epigenomics;Exposure to;Extracellular Matrix;fecal transplantation;Feces;Fellowship;Future;Ganglia;Gastroenteritis;Gastroenterologist;gastrointestinal;Gastrointestinal Motility;Gastrointestinal tract structure;Gastrointestinal Transit;Gene Expression;Germ-Free;Gnotobiotic;gut microbes;gut microbiota;Health;Hormones;human old age (65+);Image;imaging approach;imaging modality;Impairment;imprint;improved;in vivo;innovation;insight;Intervention;Intestines;Investigation;Irritable Bowel Syndrome;Laboratories;Life;Manometry;Maternal Deprivation;Mediating;Microbe;microbial;microbiome;microbiota;Morphology;Motility;motility disorder;mouse model;Multimodal Imaging;Mus;nervous system development;Neuroglia;Neurons;novel;Pathway interactions;Patients;Pattern;Phylogenetic Analysis;Physicians;Physiological;Pilot Projects;Population;postnatal development;Prevention;Probiotics;Process;Quality of life;Regulation;Research;research facility;Resistance;Resources;Risk Factors;Role;Scientist;Severities;Signal Transduction;single nucleus RNA-sequencing;Starch;Stimulus;Stress;stressor;Structure;Supplementation;Synapses;synaptogenesis;Time;Tissues;Training;transcriptome sequencing;transcriptomics;Universities;WNT Signaling Pathway

PROJECT_TITLE: Microbiota-dependent early life programming of gastrointestinal motility


ORG_CITY: GAINESVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: FL

PHR: Vagal nerve stimulation may hold the key to treating many different conditions, including obesity. Obesity is a growing epidemic in our country. Obese veterans are at risk for hypertension, diabetes, and depression. Stimulating the vagal nerves, which innervate the stomach, with small, therapeutic levels of electricity provides a potential avenue for weight loss, but is not well understood. Successful reduction of excess body weight has been reported, but stimulus parameters are quite variable and it is unclear how parameters map to outcomes. A new, promising method of stimulation has been shown to produce natural sensations when applied to peripheral nerves and the spinal cord and has reduced consumption of high fat diet. This research aims to map the relationship between stimulus parameters and 1) nerve recruitment, 2) brain activity, and 3) food consumption. This research will also evaluate a novel stimulus waveform and interface for delivering more effective vagal nerve stimulation. Studies will be conducted in rats.

PI_NAMEs: SCHIEFER, MATTHEW ANTHONY (contact)

PROJECT_TERMS: Affect;Agreement;Animal Experiments;Animals;Anodes;Anterior;Axon;bariatric surgery;Bilateral;Body Weight;Body Weight decreased;Brain;Brain imaging;Brain Mapping;Brain region;Bypass;Cathodes;Charge;Clinical;clinical practice;Communities;comorbidity;Computer Simulation;Consumption;cost;Country;Data;design;Diabetes Mellitus;Diet;diet and exercise;Eating;efficacy evaluation;Electricity;Electrodes;Epidemic;Esophagus;Esthesia;Exhibits;Fiber;Food;food consumption;Functional Magnetic Resonance Imaging;Future;Goals;Health;Healthcare;Heart Diseases;High Fat Diet;Histology;Hypertension;Hypothalamic structure;Implant;implantation;innovation;Knowledge;Lateral;Link;Magnetic Resonance Imaging;Manuscripts;Maps;Mechanoreceptors;Mental Depression;Methodology;Methods;Nerve;neuroimaging;novel;obese person;Obesity;obesity management;Outcome;Output;Overweight;Pathway interactions;Peripheral Nerves;Play;Population;pre-clinical;primary outcome;rate of change;Rattus;recruit;reduced food intake;Reporting;Research;Research Personnel;Resistance;response;Rewards;Risk;Role;Route;Safety;Satiation;Sensory;Series;Shapes;Spinal Cord;Stimulus;Stomach;Stretching;System;Technology;Testing;Therapeutic;Time;Translations;Vagus nerve structure;Variant;Veterans;Veterans Health Administration;Visceral Afferents;Width;Work

PROJECT_TITLE: Developing a novel stimulus paradigm and interface of vagal nerve stimulation (VNS) to treat obesity


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cancer

ORG_CITY: HOUSTON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: The rich information content of advanced imaging methods, combined with the growing capacity to collect multiple types of images from various sources and time points during therapy creates an exciting opportunity for image-based guidance and assessment of interventions for radiation oncology, surgery, and interventional radiology. However, several obstacles prevent the full exploitation of this paradigm including understanding and validating the imaging signals to enable high precision treatment, engaging advanced imaging techniques to assess the patient’s response to treatment, and empowering multi-disciplinary teams of physicians and scientists to address these clinical challenges and technology barriers to enable the translation of innovative science directly to patient care. This post-doctoral training program will provide the multi-disciplinary education needed for tomorrow’s pioneering researchers to advance the field of image guided cancer therapy.

PI_NAMEs: BROCK, KRISTY  (contact);FULLER, CLIFTON DAVID;LAI, STEPHEN Y

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: cancer therapy;image guided;Training Programs

PROJECT_TITLE: Image Guided Cancer Therapy Training Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cerebrovascular;Childhood Injury;Clinical Research;Epilepsy;Infant Mortality;Neurodegenerative;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Unintentional Childhood Injury

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Neonatal hypoxic-ischemic brain injury is the leading cause of neonatal seizures, for which treatment is both ineffective and potentially harmful. The immediate goals of this proposal are to develop two-photon imaging methods for in vivo real-time seizure and cell death monitoring and to define the relationship between neuronal seizure burden and the probability of cell death in a neonatal murine model of hypoxic-ischemic brain injury. The experiments proposed will generate rigorous correlational data between seizure burden and the probability of neuronal death with the necessary temporal and spatial resolution to make possible future studies of causation, which are essential to determine how aggressively to treat patients and how to prioritize future research efforts to develop improved neonatal seizure treatment strategies.

PI_NAMEs: MCNALLY, MELANIE A (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Address;Advisory Committees;Anticonvulsants;Award;Benzodiazepines;Biological Markers;Brain;Brain Injuries;Bumetanide;Calcium;calcium indicator;career;career development;Cell Death;Cells;Cerebral Palsy;Cessation of life;Chronic;Clinical;clinical care;clinically relevant;Correlation Studies;Data;Data Correlations;design;Detection;Development Plans;Developmental Delay Disorders;Dyes;effective therapy;Electroencephalography;Epilepsy;Epileptogenesis;Etiology;experimental study;Extinction;Fluorescence;Foundations;Funding;Future;General Hospitals;Goals;Hypoxia;Hypoxic-Ischemic Brain Injury;Image;imaging modality;improved;in vivo;Individual;Infant;Injury;innovation;Institution;interest;Laboratories;Ligation;Link;Magnetic Resonance Imaging;Massachusetts;Measurement;Measures;medical schools;Mentorship;Methodology;Methods;Modeling;Monitor;mortality;mouse model;Mus;Neonatal;Neonatal Brain Injury;neonatal hypoxic-ischemic brain injury;neonatal mice;neonatal seizure;neonate;Neurological outcome;neuron loss;Neurons;neuroprotection;neurotoxicity;newborn brain injury;Opsin;optogenetics;Outcome;Patients;Phenobarbital;Phenytoin;Predictive Value;Probability;Process;Proteins;pup;real time model;real time monitoring;red fluorescent protein;Research;Research Priority;Resolution;Resources;Rodent Model;Science;Scientist;Seizures;severe injury;Severities;skills;targeted treatment;Techniques;Technology;temporal measurement;Term Birth;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;Time;Training;Transgenic Mice;Transgenic Organisms;treatment strategy;two-photon;United States National Institutes of Health

PROJECT_TITLE: Neuronal Seizure Burden versus Cell Death after Neonatal Brain Injury


ORG_CITY: College Station

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because understanding how individuals respond differentially to diet, the basis of precision nutrition, is expected to greatly improve cardiometabolic health in ways that generalize diet recommendations have failed to achieve. Thus, this proposal is relevant to the aspect of NIH’s mission using nutrition to prevent or delay disease by fostering fundamental discoveries, approaches, and innovative research strategies to improve human health.

PI_NAMEs: THREADGILL, DAVID W. (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Address;American;base;Behavior;Behavior Therapy;Biological;Biological Markers;Cardiometabolic Disease;cardiometabolism;cardiovascular health;Characteristics;clinical phenotype;Communities;Data;data integration;data repository;data resource;Databases;Development;Diet;dietary;dietary guidelines;Dietary Intervention;Dietary Practices;Disease;epidemiologic data;Evaluation;Experimental Genetics;feeding;Fostering;Foundations;Future;Genes;Genetic;genetic analysis;genetic architecture;Genetic Markers;Genetic Variation;Genome;Genomic Segment;Goals;Health;Human;human model;improved;Incidence;Individual;innovation;Japanese;ketogentic;Measurement;Mediation;Metabolic;Mission;Modeling;Molecular;Molecular Analysis;molecular marker;molecular phenotype;mouse genetics;Mus;novel;nutrition;Nutritional Study;obesity prevention;Outcome;Patients;Phenotype;Physiological;Play;Population;Precision Health;precision nutrition;prevent;public database;Public Health;Publishing;Recommendation;repository;Research;response;Role;Sampling;Sensitivity and Specificity;sex;Strategic Planning;System;Testing;Tissue Banks;tissue resource;trait;United States National Institutes of Health;unpublished works;Vegan Diet;Work

PROJECT_TITLE: Foundational studies for precision nutrition

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: OD

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: COLUMBIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: PROJECT NARRATIVE The crucible of evolution has naturally shaped traits over the entire history of life and understanding the genetic basis of this adaptive process has broad applications. Comparatively diverse species, such as the Mexican cavefish Astyanax mexicanus, that have evolved physiological phenotypes and mimic some aspects of human diseases but intriguingly they do not exhibit the same underlying pathophysiological consequences require further study. We propose to build a toolbox of molecular resources for Astyanax mexicanus to significantly advance trait dissection in this amazing model of genetic adaptation.

PI_NAMEs: KEENE, ALEX C;WARREN, WESLEY CHARLES (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: Address;Amaze;Animal Model;Animals;Atlases;Biological;Biological Models;Biology;blind;Blood Glucose;Body System;Candidate Disease Gene;cardiac regeneration;Cell Lineage;Cell Physiology;Cell surface;cell type;Cells;Chromosome Mapping;Chromosomes;Communities;comparative;Coupled;data resource;Data Set;Development;Diabetes Mellitus;Differentiated Gene;Discipline;Disease;Dissection;Environment;environmental change;environmental stressor;Evolution;Exhibits;experimental study;Expression Library;Fishes;Gene Expression;Gene Expression Regulation;gene network;gene regulatory network;Generations;Genes;Genetic;Genetic Diseases;genetic manipulation;Genetic Models;genetic technology;Genome;genome wide association study;Genomic approach;Genomics;Haplotypes;Health;human disease;Human Genetics;improved;Individual;insight;Knowledge;knowledge base;Laboratories;life history;Longevity;Maps;Medicine;Methodology;Methods;Mexican;model organism;Modeling;Molecular;molecular marker;novel;Obesity;Outcome;Pathway interactions;Phenotype;Physiological;Physiology;Population;Positioning Attribute;precision medicine;preservation;Process;Recording of previous events;reference genome;Reporter Genes;Research;Resolution;Resources;response;Route;Shapes;single cell sequencing;single-cell RNA sequencing;Sleep Deprivation;Sleep Disorders;Surface;technological innovation;Technology;teleost;Testing;Time;tool;trait;Transcend;transcriptome;Transgenic Organisms;Variant;Work;Zebrafish

PROJECT_TITLE: A genomic toolkit for functional interrogation of trait variation in an aquatic model

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-A(55)R]


ORG_CITY: PITTSBURGH

ORG_STATE: PA

PHR: Veterans with chronic obstructive pulmonary disease (COPD) are a vulnerable group for developing insomnia, with about 37% having comorbid insomnia. Pulmonary rehabilitation is a key component of COPD management, yet it does not address sleep. Comorbid insomnia may interfere with veterans achieving maximum benefits from pulmonary rehabilitation. Implementing an insomnia-specific treatment in veterans with COPD undergoing pulmonary rehabilitation will likely lead to improved sleep that could help improve and sustain the benefits gained from pulmonary rehabilitation. We propose a randomized clinical trial to compare the effects of Internet- based cognitive-behavioral therapy for insomnia plus home-based pulmonary rehabilitation versus home-based pulmonary rehabilitation only on sleep and health-related functioning.

PI_NAMEs: LUYSTER, FAITH S (contact)

PROJECT_TERMS: 2019-nCoV;Achievement;actigraphy;Activities of Daily Living;Asthma;barrier to care;Behavior;Belief;care delivery;Chronic Obstructive Pulmonary Disease;chronic respiratory disease;Cognitive Therapy;Comorbid Insomnia;comparative efficacy;cost;daily functioning;diaries;Disease Management;Education;Enrollment;Ensure;Exclusion;Exercise;exercise capacity;Exercise Tolerance;exercise training;Exposure to;Fatigue;follow-up;functional outcomes;Goals;Health;Health behavior change;health care service utilization;Home;improved;improvement on sleep;indexing;innovation;Internet;Intervention;Light;Lung Diseases;Maintenance;Measures;Mediating;military veteran;Morbidity - disease rate;multidisciplinary;Nonpharmacologic Therapy;Outcome;Patient Self-Report;Patients;Performance;Physical activity;primary outcome;pulmonary function;pulmonary rehabilitation;Quality of life;Quality of Life Assessment;Questionnaires;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;remote delivery;Reporting;respiratory;Risk;secondary outcome;Self Management;Severities;Sleep;Sleep Disorders;sleep health;sleep quality;Sleeplessness;Spirometry;Symptoms;System;telehealth;Testing;Transportation;treatment effect;treatment program;United States Department of Veterans Affairs;Veterans;Vulnerable Populations;Walking;Work

PROJECT_TITLE: Enhancing pulmonary rehabilitation in veterans with chronic obstructive pulmonary disease through internet-based cognitive-behavioral treatment for insomnia

STUDY_SECTION_NAME: Chronic Medical Conditions & Aging[RRD6]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative (three sentences) Many human cancers are caused by mutations or dysfunction of genes for chromatin regulators, which regulate the accessibility of the human genome to DNA repair, replication and expression. To date effective therapeutics have not been devised for these cancers, in part because of a lack of understanding of how they normally function. We will explore the molecular mechanisms that underly the cancers produced by these chromatin regulators with the hope of providing new therapeutic strategies.

PI_NAMEs: CRABTREE, GERALD R. (contact)

PROGRAM_OFFICER_NAME: COUCH, JENNIFER A

PROJECT_TERMS: Address;Biochemical;cancer cell;Cancer Etiology;Cell Cycle;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Complex;Conflict (Psychology);crosslink;defined contribution;DNA Repair;dosage;Drosophila genus;Drosophila melanogaster;Epigenetic Process;Eukaryota;fly;Frequencies;Functional disorder;Genes;Genetic;Genome;Genomics;Goals;histone modification;Histones;Human;Human Genome;In Vitro;in vivo;Knowledge;loss of function mutation;Malignant - descriptor;Malignant Neoplasms;mammalian genome;Mass Spectrum Analysis;Measurement;Measures;Methods;Modification;Molecular;Mutate;Mutation;Neurodevelopmental Disorder;non-genetic;Normal Cell;novel therapeutic intervention;Nucleosomes;Oncogenic;Pathogenesis;Phenotype;Play;Polycomb;Post-Translational Protein Processing;PRC1 Protein;rate of change;Repression;Role;Shapes;Site;Specificity;Squamous cell carcinoma;Squamous Cell Lung Carcinoma;synovial sarcoma;Techniques;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutically effective;Tumor Suppressor Proteins;Yeasts

PROJECT_TITLE: ATP-Dependent Chromatin Remodeling in Human Malignancy

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Emerging Infectious Diseases;Genetics;HIV/AIDS;Hematology;Human Genome;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: Kaposi's sarcoma-associated herpesvirus (KSHV) is a class I carcinogen and the major cause of cancer in untreated AIDS patients. During KSHV infection there is a dramatic reprogramming of cellular gene expression driven by the virus and this contributes to disease progression. This grant investigates the role of transposable elements in remodeling cellular gene expression during KSHV infection and how this contributes to disease.

PI_NAMEs: KARIJOLICH, JOHN  (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affect;antiretroviral therapy;Area;B-Lymphocytes;Binding;Bioinformatics;Biology;Cancer Etiology;Carcinogens;Cell Reprogramming;Cells;Cellular biology;Chromatin;chromatin modification;Communicable Diseases;CRISPR interference;CRISPR screen;Data;Disease;Disease Progression;Disease remission;DNA Transposable Elements;DNA Viruses;effective therapy;Elements;Endothelial Cells;Enhancers;Environment;Etiology;experimental study;Family;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic analysis;genetic element;Genetic Transcription;Genome;genome-wide;Genomic Segment;Grant;Herpesviridae;Herpesviridae Infections;HIV;Human Herpesvirus 8;Infection;insight;Introns;Kaposi Sarcoma;Laboratories;latent infection;Life Cycle Stages;Literature;Location;Lymphoma cell;Lytic;Lytic Phase;Maintenance;Malignant Neoplasms;Mammalian Cell;Maps;Mediating;Non-Hodgkin's Lymphoma;Oncogenic;Outcome;Pathogenesis;Pathway interactions;Patients;Persons;Phase;Phenotype;Play;Population;primary effusion lymphoma;Primary Lesion;Process;Production;promoter;Proteins;Publishing;Regulation;Regulatory Element;Resolution;Retrotransposon;Risk;RNA;RNA Polymerase II;Role;Series;stem cell biology;Stress;targeted treatment;Techniques;Technology;Testing;therapeutic development;Time;Transcript;transcription factor;Transcription Initiation;Transcription Initiation Site;Transcriptional Regulation;transcriptome;transcriptome sequencing;tumorigenesis;Untranslated Regions;Viral;Viral Genes;Virion;Virus;virus host interaction

PROJECT_TITLE: (PQ#2) Transposable element-mediated gene regulation in KSHV-associated cancer


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Comparative Effectiveness Research;Dementia;Health Services;Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Over a million patients admitted annually to skilled nursing facilities (SNFs) for post-acute care after a hospitalization have Alzheimer’s Disease or Related Dementias (ADRD), and their outcomes are poor and variable. The current study will examine whether physicians that specialize in SNF-based care (SNFists) improve functional outcomes and reduce healthcare utilization of patients with ADRD receiving care in SNFs. We will also qualitatively evaluate how physician practices differ between high- vs. low-performing SNFs.

PI_NAMEs: JUNG, HYE-YOUNG ;RYSKINA, KIRA L (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: acute care;Administrator;Admission activity;Affect;Alzheimer's disease patient;Alzheimer's disease related dementia;beneficiary;care coordination;care delivery;care outcomes;Caring;Characteristics;Clinical;Clinical assessments;Communication;Communities;Complex;Continuity of Patient Care;cost;Data;Data Set;Databases;Emergency department visit;Employment;evidence base;experience;Fee-for-Service Plans;functional improvement;functional outcomes;functional status;Goals;Grant;Growth;Health care facility;health care service utilization;hospital care;hospital readmission;Hospitalization;hospitalization rates;Human Resources;improved;improved outcome;Intervention;Interview;Length of Stay;Link;Long-Term Care;loss of function;Marketing;Measures;Medicare;Medicare claim;memory care;Nurse Administrator;Nursing Homes;Nursing Staff;Outcome;Ownership;Patient Admission;Patient Care;Patient-Focused Outcomes;Patients;Penetration;Persons;Physician Executives;Physicians;Play;Policies;Prevalence;Process;readmission rates;Recovery;Research;residence;Role;Sampling;Site;Skilled Nursing Facilities;Specialist;Structure;therapy development;Training;trend;Visit;Work

PROJECT_TITLE: Post-acute Care Outcomes of Patients with Alzheimer's Disease and Related Dementias: the Role of Skilled Nursing Facility Specialists

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

PHR: Project Narrative: The conventional clinical management strategy for patients with chronic myelomonocytic leukemia (CMML) is to initiate therapy at the time of disease progression and clonal evolution. In this project, we will determine whether inflammatory insults can drive a specific evolutionary adaption known as the `mono-biased' state and disease progression. Importantly, we will determine if this inflammation dependent effect can be mitigated by existing therapeutics and cytokine inhibitors leading to a paradigm shift in CMML management whereby these therapies can be deployed in a clinically asymptomatic state to prevent disease progression.

PI_NAMEs: PADRON, ERIC  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acceleration;Acute Myelocytic Leukemia;Address;Adult;adverse outcome;Biological Assay;Bone Marrow;CD34 gene;Cells;Chronic;Chronic Myelomonocytic Leukemia;Classification;Clinical;Clinical Management;Clonal Evolution;cytokine;Cytokine Network Pathway;Cytokine Receptors;cytopenia;Data;design;Diagnosis;Disease;disease natural history;Disease Progression;Dysplasia;Early treatment;Erythroid;Event;fitness;follow-up;Gene Expression Profile;Gene Frequency;Gene Mutation;genetic architecture;Genetic Engineering;Genetic Transcription;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;granulocyte-monocyte progenitors;Hematopoiesis;Hematopoietic;hematopoietic stem cell differentiation;Hematopoietic stem cells;Human;Immunocompromised Host;Infection;Inflammation;Inflammatory;inflammatory milieu;inhibitor;Institution;JAK1 gene;Knowledge;Laboratories;leukemia;Leukemic Cell;Leukemic Hematopoietic Stem Cell;leukemic transformation;Literature;Longitudinal cohort;Longitudinal cohort study;Longitudinal Studies;Malignant - descriptor;Megakaryocytes;Modeling;Molecular;Monitor;monocyte;Monocytosis;mortality;Myeloid Cells;Myeloid Leukemia;Myeloproliferative disease;Natural History;Nature;Non-Malignant;overexpression;Pathologic;patient subsets;Patients;Peripheral;peripheral blood;Phase I/II Clinical Trial;Phenotype;Population;pre-clinical;Pre-Clinical Model;prevent;Process;progenitor;Prognosis;programs;Proliferating;prospective;response;Retrospective cohort;Sampling;Sampling Studies;self-renewal;Somatic Mutation;stem cell expansion;Stimulus;Stress;Subgroup;Systemic infection;Testing;Therapeutic;Time

PROJECT_TITLE: The impact of inflammation on HSPC composition and disease progression in chronic myelomonocytic leukemia

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety;Radiation Oncology

ORG_CITY: CHICAGO

PHR: PROJECT NARRATIVE NCTN trials set the standards for cancer treatment in the United States and across the world. The significant recent advances in the basic sciences cannot benefit patients unless new treatments are proven safe and beneficial in the clinical setting. UCCCC will contribute to the goals of the NCTN by providing the scientific leadership to develop trials that have a significant impact on treatment and the infrastructure to effectively accrue to clinical trials across the NCTN.

PI_NAMEs: CHMURA, STEVEN J;KINDLER, HEDY L (contact);POSNER, MITCHELL C;YAMADA, SEIKO D

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Adolescent and Young Adult;Adult;Advisory Committees;American College of Surgeons Oncology Group;Basic Science;Cancer and Leukemia Group B;Cancer Center Support Grant;cancer clinical trial;cancer therapy;Chicago;Clinical;Clinical Data;Clinical Protocols;Clinical Research;Clinical Treatment;Clinical Trials;Clinical Trials Network;Collaborations;Community Outreach;Comprehensive Cancer Center;Correlative Study;Data Coordinating Center;data management;data quality;Dedications;design;Development;Discipline;Disease;Ensure;Equity;experience;Faculty;Future;Goals;Gynecologic Oncology;Gynecologic Oncology Group;Infrastructure;innovation;Institution;Laboratories;Lead;Leadership;Malignant - descriptor;Malignant Neoplasms;Manuscripts;Medical Oncology;Medicine;member;Mentors;Minority Groups;multidisciplinary;National Clinical Trials Network;Oncology;operation;outreach program;patient population;Patients;Phase;Principal Investigator;programs;Protocols documentation;Publishing;Qualifying;Quality Control;Radiation Oncology;Radiation Therapy Oncology Group;rare cancer;Rare Diseases;Research;Research Personnel;Resources;senior faculty;Site;Special Population;statistics;Surgical Oncology;Testing;translational study;tumor;Underserved Population;United States;Universities;Vision;Work;working group

PROJECT_TITLE: UG1 - NCTN (Network Lead)


PHR: The drug supply chain is global and susceptible to disruptive unanticipated events, such as the 2019 Corona- virus (COVID-19) pandemic, but the impact of drug shortages during a global public health emergency and the impact on Veteran drug supply and health outcomes are unknown. The proposed research is relevant to Veteran health because policy-makers need real world evidence to plan for future global emergencies, drug shortages at large, and inform VA policy to decrease the impact of drug shortages on Veteran outcomes. Thus, this project is relevant to the priority areas of HSR&D, VA operations, and other federal initiatives to provide timely response to critical questions, ensure the availability of safe and effective drugs to our Vet- erans, measure drug shortages and their impact on patient safety, improve resiliency of the drug supply chain, and achieve health equity, especially in VA priority groups.

PI_NAMEs: SUDA, KJ  (contact)

PROJECT_TERMS: acute care;Address;adverse outcome;Affect;Age;Area;Cessation of life;Characteristics;Chinese;Clinical;cohort;comorbidity;Consumption;Coronavirus;coronavirus pandemic;COVID-19;COVID-19 impact;Data;Department of Defense;Disease;Dosage Forms;drug distribution;Drug usage;Effectiveness;effectiveness evaluation;Elderly;Emergency Situation;Ensure;Entropy;Equilibrium;Equity;ethnic minority;Ethnic Origin;Event;experience;Exposure to;Frequencies;Future;Goals;Government;Health;health equity;Healthcare Systems;Homogeneously Staining Region;Hospitalization;improved;Incidence;Individual;innovation;Inpatients;Interruption;Knowledge;Laws;Location;manufacture;Manufactured form;Measures;Medicine;Methodology;Methods;Modeling;Monitor;multiple chronic conditions;Multiple Partners;operation;Outcome;Outpatients;pandemic disease;pandemic impact;patient safety;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacologic Substance;pharmacy benefit;Policies;Policy Maker;Predisposition;premature;prevent;Probability;Procedures;Production;promote resilience;Public Health;public health emergency;Race;racial minority;Reaction Time;Reporting;Research;Research Design;resilience;Retrospective cohort study;Risk;Rural;rural dwellers;Series;Services;Statutes and Laws;supply chain;System;Testing;Time;Time Series Analysis;time use;tool;United States Food and Drug Administration;United States Indian Health Service;urgent care;Veterans;Visit;Voting;Work

PROJECT_TITLE: The broken drug supply chain: The impact of COVID-19 on drug shortages and Veteran health

STUDY_SECTION_NAME: HSR-5 Health Care System Organization and Delivery and Women's Health[HSR5]


ORG_CITY: Decatur

ORG_STATE: GA

PHR: Every year about 15,000 Veterans are hospitalized for stroke (Cowper 2004), and one-third of those patients develop stroke-related language disorders (aphasia) (Brady 2012). The first few months of post-stroke recovery is a critical time period where spontaneous changes in language functions and underlying neural processes are observed. Imaging brain changes during this time may help clinicians identify the recovery of neural processes, but must be done in a way that is not confounded by stroke-induced cerebrovascular changes. This CDA2 proposal addresses this gap through development of a set of integrated multi-modal neuroimaging methodologies to accurately identify neural systems associated with language recovery from early sub-acute (2- 6 weeks post-stroke) to late sub-acute phase (12-16 weeks post-stroke) of aphasia recovery.

PI_NAMEs: KRISHNAMURTHY, VENKATAGIRI  (contact)

PROJECT_TERMS: Acute;Address;Aphasia;aphasia recovery;aphasia rehabilitation;Area;Auditory;Behavior;behavior change;behavior prediction;Behavioral;Biological Markers;blood oxygen level dependent;Blood Vessels;Brain;Brain imaging;Brain region;career;career development;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Physiology;cerebrovascular reactivity;Chronic;clinical outcome measures;clinical translation;clinically relevant;Cognitive;Comprehension;Data;Development;Dissociation;Early treatment;Etiology;expectation;Fatigue;Foundations;Functional Magnetic Resonance Imaging;functional MRI scan;Goals;Hospitalization;Impairment;improved;Ischemic Stroke;Knowledge;Language;Language Disorders;lexical;Maps;Masks;Measures;Methodology;Modeling;multimodal neuroimaging;multimodality;Names;neural;neuroimaging;Neuronal Plasticity;neurovascular;novel;Outcome;Pathway Analysis;Patient Participation;Patient Recruitments;Patients;Phase;Philadelphia;Physiology;post stroke;predict clinical outcome;Prediction of Response to Therapy;predictive modeling;Process;Recovery;Reperfusion Therapy;Research;Residual state;response;Rest;Scheme;Scientist;Signal Transduction;Stroke;stroke recovery;synergism;System;Techniques;Testing;Time;tool;Training;Treatment outcome;vascular contributions;Vascular remodeling;Veterans

PROJECT_TITLE: Multimodal Neuroimaging: Advanced Tracking of Longitudinal Aphasia Recovery

STUDY_SECTION_NAME: Career Development Program - Panel I[RRD8]


ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: LEXINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE - OVERALL The University of Kentucky (UK) Center of Biomedical Research Excellence (COBRE) in Pharmaceutical Research and Innovation (CPRI) will serve as a unique comprehensive translational chemical biology center. The center will support junior faculty career development, advance impactful chemical biology and pharmaceutical science research/tools, and stimulate transdisciplinary collaboration, research innovation and early preclinical translational research.

PI_NAMEs: THORSON, JON SCOTT (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: Address;Area;Biology;Biomedical Research;Cardiovascular Diseases;career development;Centers of Research Excellence;Chemicals;Clinical;clinical application;Collaborations;college;Communicable Diseases;Communication;Core Facility;Development;Devices;Discipline;Disease;Education;Environment;experience;Faculty;faculty research;Fostering;Funding;Goals;Health;Infrastructure;innovation;Institution;interdisciplinary collaboration;interest;Kentucky;Malignant Neoplasms;Mentors;Mentorship;Modeling;Molecular Medicine;multidisciplinary;Organic Synthesis;Outcome;Pharmacologic Substance;Pharmacy facility;Phase;pre-clinical;pre-clinical research;prevent;Productivity;Research;Research Personnel;Research Project Grants;Research Support;Science;Scientist;Testing;Therapeutic;tool;Translational Research;Translations;Universities;Validation

PROJECT_TITLE: Center of Biomedical Research Excellence in Pharmaceutical Research and Innovation


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Address;Agriculture;Arts;Biological;Biology;Biomedical Research;Cancer Center;Cardiovascular Diseases;career;career development;Career Mobility;Centers of Research Excellence;Chemicals;Clinical;clinical application;clinical center;Clinical Sciences;college;Communication;Decision Making;Development;Development Plans;Devices;Discipline;Disease;Education;Engineering;Ensure;Environment;Evaluation;Faculty;faculty research;Food;Fostering;Goals;Health;Human Resources;improved;Infrastructure;innovation;Institution;interdisciplinary collaboration;Kentucky;Knowledge;Leadership;Medicine;Mentors;Mentorship;Modeling;Molecular Medicine;multidisciplinary;Obesity;operation;Oral;Outcome;outreach;Pharmacologic Substance;Pharmacy facility;prevent;primary outcome;Process;Program Effectiveness;Program Evaluation;programs;Research;Research Personnel;Research Priority;Research Support;Resource Allocation;Resource Sharing;Resources;Science;stem;Structure;success;supportive environment;synergism;Systemic disease;tool;Translational Research;Translations;tumor metabolism;Universities;Validation

PROJECT_TITLE: Administrative Core


PI_NAMEs: LEGGAS, MARKOS  (contact)

PROJECT_TERMS: absorption;Acceleration;Address;Adhesions;Animals;antimicrobial;Basic Science;Biological Assay;Biology;Biomedical Research;career development;Centers of Research Excellence;Chemicals;Clinical;clinical application;Clinical Research;Collection;Complement;Consultations;cytotoxicity;Data Analyses;Dedications;design;Development;Devices;Disease;Doctor of Philosophy;Drug Kinetics;Excretory function;experimental study;Faculty;faculty research;Goals;Health;immunoregulation;In Vitro;Infrastructure;innovation;instrumentation;Kentucky;Lead;Leadership;Libraries;Mentors;Mentorship;Metabolism;Methods;Microbial Biofilms;Modeling;Molecular Medicine;multidisciplinary;Natural Products;Organic Synthesis;Pharmacologic Substance;pre-clinical;prevent;primary outcome;Reporter;Research;Research Design;research faculty;Research Personnel;Research Support;Resources;Science;Scientist;screening;screening services;Services;stem;synergism;tool;Toxic effect;transcription factor;Translational Research;Type IV Secretion System Pathway;Universities;Validation

PROJECT_TITLE: Translational Core


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: Project Narrative Deficiencies in mechanosensation contribute to functional gastrointestinal diseases (FGIDs) like irritable bowel syndrome (IBS), which collectively affect around 15% of US adults, but mechanosensation has not been directly targeted for treatment because of poor mechanistic understanding of how physical forces influence GI function. Our lab discovered mechanosensitive enteroendocrine cells (EECs) in the GI epithelium that release physiologically active hormones in response to force, so in this proposal we seek to uncover the mechanism by which mechanosensitive proteins work together to make EECs efficient force sensors. Acquiring this knowledge may advance our understanding of mechanosensation in sensory epithelia, and pinpoint targets for the treatment of FGIDs.

PI_NAMEs: MERCADO-PEREZ, ARNALDO  (contact)

PROJECT_TERMS: Actins;Adult;Affect;arm;Biology;Calcium;Cell Adhesion Molecules;Cells;claudin 4;clinical training;clinically relevant;Co-Immunoprecipitations;Collaborations;Cytoskeleton;Data;Disease;Doctor of Philosophy;Electrophysiology (science);Elements;Enteroendocrine Cell;Epithelium;Esthesia;Exhibits;experience;experimental study;Face;Fiber;force sensor;Functional disorder;Future;Gastrointestinal Diseases;gastrointestinal epithelium;Goals;Hormone secretion;Hormones;Image;Imaging Techniques;Impairment;Individual;Ion Channel;Ion Channel Gating;Irritable Bowel Syndrome;knock-down;Knowledge;Knowledge acquisition;Lateral;Light;Link;Measures;Mechanical Stress;Mechanics;mechanotransduction;Mediating;Membrane;Mentors;Molecular;Motility;Mucous Membrane;Muscle Contraction;Neurons;novel;optogenetics;Organoids;patch clamp;Patients;pharmacologic;Physicians;Physiological;Physiology;Piezo 2 ion channel;Play;Population;Process;Proteins;receptor;Reflex action;Research Activity;response;Role;Scientist;selective expression;Sensory;Serotonin;Signal Transduction;Signaling Molecule;skills;Skin;Small Interfering RNA;Specific qualifier value;Stretching;superresolution imaging;superresolution microscopy;supportive environment;Surgeon;targeted treatment;Testing;Tight Junctions;Tissue Model;Tissues;tool;Touch sensation;Training;transmission process;Visualization;Work

PROJECT_TITLE: Role of cytoskeletal interactions with mechanogated ion channel Piezo2 in the mechanism of mechanotransduction by enteroendocrine cells


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Networking and Information Technology R&D (NITRD)

PI_NAMEs: ZHAN, CHANG-GUO  (contact)

PROJECT_TERMS: absorption;Acceleration;Address;Artificial Intelligence;Basic Science;Biology;Biomedical Research;career development;Centers of Research Excellence;Chemicals;Clinical;clinical application;Clinical Research;Complement;Complex;Computer Hardware;Computer software;Computing Methodologies;Consultations;Data Analyses;design;Development;Devices;Diffusion;Disease;DNA;Doctor of Philosophy;Excretory function;experimental study;Faculty;faculty research;Goals;Gold;Health;Individual;Infrastructure;innovation;intermolecular interaction;Kentucky;Lead;Leadership;Ligands;Macromolecular Complexes;Mentors;Mentorship;Metabolism;Methods;Modeling;models and simulation;Molecular;molecular dynamics;Molecular Medicine;molecular modeling;multidisciplinary;nanoparticle;Organic Synthesis;particle;Pharmacologic Substance;pre-clinical;prevent;primary outcome;Process;protein complex;Proteins;Protocols documentation;Research;Research Design;research faculty;Research Personnel;Research Support;Resources;Science;Scientist;self assembly;Services;simulation;stem;Structure;synergism;Techniques;tool;Toxic effect;Training;Translational Research;Universities;Validation;virtual screening

PROJECT_TITLE: Computational Core


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Clinical Research;Women's Health Research

ORG_DEPT: MISCELLANEOUS

PHR: As biomechanical modeling of the breast is integral to predicting tumor location across multimodal diagnostic imaging and during surgery, surgical planning, generating simulations for physician and patient education, and brassiere and clothing design for optimal breast support, advances in model accuracy have the potential to significantly improve women's health and quality of life. Despite the growing use of breast biomechanical models for different applications, there are persistent knowledge gaps in both the anatomical and biomechanical literature that prevent an accurate model from being developed and deployed to patient-specific applications. This research aims to improve the accuracy of the biomechanical model by determining the anatomical and biomechanical characteristics of the fascial support system of the breast, understanding the sensitivity of the patient-specific parameters across the population, and validating the translation of these models, with their inherent uncertainties, into the patient-specific setting.

PI_NAMEs: BROCK, KRISTY  (contact);REECE, GREG PAUL;SACKS, MICHAEL S

PROGRAM_OFFICER_NAME: FALCONE, JESSICA

PROJECT_TERMS: 3-Dimensional;Adipose tissue;Anatomy;Anisotropy;Behavior;biomechanical model;biomechanical test;Biomechanics;Breast;Characteristics;Chest wall structure;clinical translation;Clothing;Data;design;Development;Diagnosis;Diagnostic Imaging;Engineering;Geometry;Goals;Grant;Human;improved;Individual;innovation;Knowledge;Literature;Location;Malignant Breast Neoplasm;Malignant Neoplasms;Mammaplasty;Mammary Gland Parenchyma;Mastectomy;Medical;Modeling;Motion;Movement;multidisciplinary;multimodality;Operative Surgical Procedures;Outcome;Outcome Measure;Pathologist;Patient Education;Patients;Performance;Physicians;Physics;Physiological;Population;prevent;primary outcome;Property;Quality of life;Recovery;Research;shared decision making;simulation;Structure;Support System;Surgeon;System;Testing;Three-dimensional analysis;three-dimensional modeling;Tissue Model;Tissues;tool;Training and Education;translational model;tumor;Uncertainty;Vision;Women's Health;Work

PROJECT_TITLE: Enhanced Biomechanical Modeling of the Breast for Womens Health

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Liver Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Nonalcoholic fatty liver disease (NAFLD) is one of the leading causes of liver disease in the US; however, much remains to be discovered regarding the genetic factors that contribute to its development. The proposed research will demonstrate that genetic variation in SUGP1 contributes to cellular lipid accumulation and NAFLD in animal models, as well as establish patient-derived induced pluripotent stem cells, a novel cellular model for the discovery and functionalization of NAFLD gene variants. Together, these results will enhance our understanding of the genetic contributors to NAFLD, which may lead to precision medicine advancements in NAFLD screening and treatment.

PI_NAMEs: MATTIS, ARAS NIKODEMAS;MEDINA, MARISA WONG (contact)

PROGRAM_OFFICER_NAME: PAWLIKOWSKA, LUDMILA SYLWIA

PROJECT_TERMS: Adult;Age;Alleles;Alternative Splicing;American;Animal Model;Biology;causal variant;Cell Differentiation process;Cell Line;Cell model;Cells;clinical diagnosis;cost;cytokine;Development;Diagnostic tests;disease diagnosis;disease model;disease phenotype;Electronic Health Record;endoplasmic reticulum stress;Fatty acid glycerol esters;Fatty Liver;Genes;Genetic;Genetic Diseases;Genetic Models;Genetic Predisposition to Disease;Genetic Risk;genetic variant;Genetic Variation;Haplotypes;Hepatic;Hepatocyte;hepatoma cell;Human;Hypertriglyceridemia;Impairment;in vivo;Incubated;Individual;induced pluripotent stem cell;knock-down;Linkage Disequilibrium;lipid biosynthesis;lipid metabolism;Lipids;Liver;Liver diseases;Liver Failure;Measures;Mediating;Modeling;mouse model;Mus;Non obese;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel strategies;Oleates;overexpression;patient derived induced pluripotent stem cells;Patients;Phenotype;Pilot Projects;Plasma;precision medicine;Proteins;Race;Regulation;Research;risk variant;screening;sex;Testing;Therapeutic;Time;tool;transcriptome sequencing;Triglycerides;Undifferentiated;Variant

PROJECT_TITLE: Genetic Regulation of Nonalcoholic Fatty Liver Disease

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


PHR: Spinal cord injury (SCI) severely impairs the quality of life for patients causing permanent loss of function below the injury. The proposed nanoparticle-mediated strategy will provide a non-invasive acute care platform that can be given immediately intravenously in the pre-hospital environment. Successful completion of the proposed studies will have the potential to develop an over-the-counter transformational platform that can lead to fast-track staging of clinical trials for SCI patients.

PI_NAMEs: PARK, JONGHYUCK  (contact)

PROJECT_TERMS: Acute;acute care;Anatomy;Binding;Cells;Centers of Research Excellence;Clinical Trials;design;Diagnosis;Environment;Equilibrium;FDA approved;Female;Formulation;Glycolic-Lactic Acid Polyester;Goals;Hospitals;Immune;Immunotherapeutic agent;Impairment;improved;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;injured;Injury;innovation;Intervention;Intravenous;intravenous administration;loss of function;male;Mediating;nanoparticle;Natural regeneration;Neurologic Deficit;Patients;Pharmacologic Substance;Pharmacological Treatment;Physiological;Play;Population;programs;Property;Quality of life;Recovery;Recovery of Function;Research;response;Role;severe injury;sex;sexual identity;Site;Spinal Cord;Spinal cord injury;Spinal cord injury patients;Spleen;Staging;Therapeutic;Tissues;trafficking;Triage

PROJECT_TITLE: Developing immunotherapeutic nanoparticles for spinal cord injury


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Regulation of transcription dictates cells’ fates, functions, and potential in development and disease. Promoter- proximal RNA Polymerase II Pausing has been shown to be a critical rate-limiting step of transcription that can control transcription’s outcome and response to extracellular signals in certain scenarios. This study aims to understand the mechanisms of Pausing influence on gene regulation and signal response in early mammalian development in vivo and in vitro, which will give insights into how this process may affect cellular response to extracellular signals and open the door to manipulating this process for therapeutic purposes.

PI_NAMEs: ABUHASHEM, ABDERHMAN ANEES (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Acute;Affect;Automobile Driving;Biological;Cell Line;Cell Physiology;cell type;Cells;Data;Development;developmental disease;directed differentiation;Disease;DNA Polymerase II;Elongation Factor;Embryo;Embryonic Development;Ensure;Epiblast;extracellular;Extracellular Signal Regulated Kinases;Failure;Fibroblast Growth Factor;gastrulation;Gene Expression Regulation;Genes;Genetic Transcription;Goals;implantation;In Vitro;in vivo;insight;Knock-out;Link;Long-Term Effects;Malignant Neoplasms;Measures;Methods;Molecular;mouse development;Mouse Embryonic Stem Cells;Mus;negative elongation factor;novel;Nuclear;Outcome;Pathway interactions;Phenotype;Play;pluripotency;Prevalence;Process;promoter;Protocols documentation;Publishing;quantitative imaging;Regulation;Resistance;response;RNA;RNA Polymerase II;Role;Running;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Techniques;temporal measurement;Testing;Therapeutic;therapeutic target;Transcription Process;Transcriptional Activation;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Work

PROJECT_TITLE: Dissecting the Role of RNA Pol II Pausing in Early Mammalian Development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-U(20)L]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Immunization;Infectious Diseases;Liver Disease;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: ROCKVILLE

ORG_NAME: SANARIA, INC.

PHR: PROJECT NARRATIVE The WHO estimates that in 2020, malaria caused 241M clinical episodes and 627,000 deaths. This was a significant increase compared to 2019. While Plasmodium falciparum (Pf) accounts for much of the severe disease and most of the deaths, P. vivax (Pv) represents the most widespread and numerous malaria parasite with a range stretching even into temperate zones. Pv comprise the greatest proportion of infections and cases in some parts of the world; for example, in the Americas 68.3% (446,000) of 653,000 cases were attributable to Pv malaria in 2019. Evidence is accumulating to show that young children and pregnant women are particularly vulnerable to adverse clinical impacts of Pv malaria, including severe presentations, and preventing infections and relapse in these groups is a priority. Pv is responsible for at least 30% of malaria in U.S. travelers [5]. Efforts to prevent and control Pv malaria are impeded by emergence of drug resistant strains and by repeated relapses from dormant liver stage parasites called hypnozoites. A powerful tool is needed for eliminating Pf and Pv malaria from defined geographical areas, ideally a highly effective, long-acting yet low-cost vaccine that prevents infection, disease and parasite transmission. This proposal describes the development, characterization and assessments of a Plasmodium falciparum sporozoite (PfSPZ) vaccine that is late arresting replication competent (LARC) and has 2 genes Pfmei2 and PfLINUP deleted (PfSPZ-LARC2) and in addition a major immunogenic Pv protein the circumsporozoite protein (CSP). We describe the development of a Pf LARC parasite strain that expresses the P. vivax circumsporozoite protein (PvCSP). This parasite strain called PfLARC2-PvCSP is genetically attenuated to arrest development in the late liver stage, and will provide the basis for a bi-valent LARC PfSPZ Vaccine.

PI_NAMEs: SIM, B. KIM LEE (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Africa;African;Americas;Anti-malarials;Antigens;Asian;Attenuated;Attenuated Vaccines;authority;Blood;cell bank;Cerebral Malaria;Cessation of life;Chemoprophylaxis;Child;Chloroquine;circumsporozoite protein;Clinical;Clinical Trials;cost;cost effective;Country;COVID-19;CRISPR/Cas technology;Culicidae;Cyclic GMP;Development;Disease;Documentation;Dose;Drug resistance;Engineering;Europe;Falciparum Malaria;Foundations;Gene Modified;Generations;Genes;Geographic Locations;Geography;Grant;hepatoma cell;Hospitalization;Human;Immunization;Immunization Programs;immunogenic;immunogenicity;In Vitro;in vivo;Individual;Infant;Infection;Infection prevention;Invaded;Knock-out;Liver;Malaria;malaria infection;Malaria Vaccines;malarial anemia;manufacture;Mass Vaccinations;Medical;mortality;Mus;Mutate;Mutation;parasite invasion;Parasites;Phase;Phase I Clinical Trials;Phase II Clinical Trials;Plasmodium falciparum;Plasmodium falciparum vaccine;Plasmodium vivax;pre-Investigational New Drug meeting;Pregnant Women;prevent;Prevention;programs;protective efficacy;Proteins;Quality Control;Radiation;Recommendation;Relapse;relapse prevention;Research;resistant strain;Running;safety assessment;Small Business Innovation Research Grant;Sporozoite vaccine;Sporozoites;Stretching;Symptoms;Thailand;tool;transmission process;Vaccination;vaccine efficacy;vaccine safety;Vaccines;Variant;Vivax Malaria

PROJECT_TITLE: A genetically modified Plasmodium falciparum sporozoite vaccine attenuated at the late-liver stage

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-U(11)]


NIH_SPENDING_CATS: Cancer

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Our goal is to train graduate students and postdoctoral Oncology Fellows to become committed cancer researchers who work to together as scholars, experimentalists, and physician-scientists to advance cancer research and treatment. We have therefore evolved this program to bring graduate students and postdoctoral Oncology Fellows to work side-by-side to grow intellectually and technically. We are particularly proud of this grant because it has allowed us to innovate in our training by developing cutting-edge courses, addressing newly recognized needs of our trainees for their career development, training a more diverse group of students, and simultaneously doing substantive, compelling cancer research.

PI_NAMEs: SUGDEN, WILLIAM M. (contact)

PROJECT_TERMS: Cancer Biology;Grant;Training

PROJECT_TITLE: Training in Cancer Biology Training Grant


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: MANHATTAN

ORG_NAME: KANSAS STATE UNIVERSITY

ORG_STATE: KS

PHR: PROJECT NARRATIVE (PUBLIC HEALTH RELEVANCE STATEMENT)  In this project, we will continue our investigation of two families of Staphylococcus aureus proteins that act as potent inhibitors of key enzyme systems required for an effective innate immune response. The first family of inhibitors, called EAP proteins, targets a series of immune proteases found within human neutrophils, as well as the classical and lectin complement pathways, while the second inhibitor, called SPIN, blocks the myeloperoxidase of neutrophils that generates cytotoxic hypohalous acids from hydrogen peroxide. Completion of this project may reveal new approaches to preventing and/or treating staphylococcal disease, provide new insight into development of anti-inflammatory therapeutics, and further our understanding of the physical phenomena underlying the host species specificity of infection.

PI_NAMEs: GEISBRECHT, BRIAN V (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Acids;Address;Adopted;Animal Model;Anti-Bacterial Agents;Anti-Inflammatory Agents;Basic Science;Binding;Biochemical;comparative;Complement;Complement Inactivators;complement pathway;complement system;cytotoxic;Data;Development;Disease;Enzyme Inhibitor Drugs;Enzymes;Event;Family;Foundations;Future;Genus staphylococcus;Gram-Positive Bacteria;Heme;Homologous Gene;Human;Hydrogen Peroxide;Immune;Immune Evasion;In Vitro;Individual;Infection;Informatics;inhibitor;Innate Immune Response;Innate Immune System;insight;Invaded;Investigation;Lectin;Microbe;Molecular Conformation;molecular recognition;neutrophil;novel;novel strategies;pathogen;Peptide Hydrolases;Peroxidases;prevent;Proteins;public health relevance;Research;response;Series;Serine Protease;Species Specificity;Staphylococcus aureus;structural determinants;Structure;System;Therapeutic;Virulence;Work

PROJECT_TITLE: Novel Enzyme Inhibitors in the Innate Immune Evasion Repertoire of Staphylococci

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


NIH_SPENDING_CATS: Bioengineering;Cancer;Nanotechnology

ORG_CITY: HOUSTON

PHR: Project Narrative Currently, there is a growing gap between new discoveries in cancer nanotechnology and their translation into clinic. To address this problem, we have designed a novel training program to prepare PhD scientists who will transfer the many promises of cancer nanotechnology into clinical reality of the future.

PI_NAMEs: BAO, GANG ;SOKOLOV, KONSTANTIN V (contact)

PROJECT_TITLE: Interdisciplinary Translational Pre/Postdoctoral Program in Cancer Nanotechnology


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric;Psychosis;Rehabilitation;Schizophrenia;Serious Mental Illness;Social Determinants of Health;Telehealth

ORG_DEPT: PSYCHIATRY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE The knowledge gathered from this project is of significant public health relevance as it has potential to advance treatment for youth at clinical high risk for psychosis (CHR) by evaluating the utility of Group and Family-Based Cognitive Behavioral Therapy for youth at CHR and examining whether adding group and family modalities may be more effective in improving psychosocial functioning compared to individual CBT. We will use telehealth delivery to address challenges that youth at CHR may have accessing treatment, including transportation to local clinics, stigma, stress sensitivity, suspiciousness, and emerging negative symptoms. Telehealth adaptations have the potential to make interventions accessible to a larger number of youth and families, to connect them to social support networks of others with similar experiences across geographically disparate locations, to alleviate their suffering, to reduce psychiatric disability, and to decrease economic losses to society.

PI_NAMEs: LANDA, YULIA  (contact)

PROGRAM_OFFICER_NAME: PUGLIESE, CARA ELISABETH

PROJECT_TERMS: acceptability and feasibility;Address;Adolescence;Aftercare;Age;Attenuated;Caregivers;Climate;Clinic;Clinical;clinical high risk for psychosis;clinical remission;Cognitive;cognitive development;cognitive function;Cognitive Therapy;Communication;comparative efficacy;cost;Data;Decision Making;Delaware;Delusions;design;Distress;Dropout;Economics;Ecosystem;Educational process of instructing;emerging adult;Emotional;experience;Family;Family member;follow-up;functional decline;functional improvement;Funding;Future;geographic disparity;Geographic Locations;Goals;Hallucinations;Health Personnel;Health Services;Health Services Accessibility;Health system;high risk;improved;Incidence;Individual;information processing;Intervention;Interview;Knowledge;Learning;Location;Manuals;Measures;Mental Health;Methods;Minority Status;Missouri;Modality;Modeling;New York;Outcome;pandemic disease;Patients;peer;peer support;Persons;Phase;pilot trial;Population;preference;prevent;programs;Provider;psychiatric disability;Psychoses;psychosis risk;psychosocial;psychotic symptoms;psychotic-like experiences;public health relevance;Randomized;Randomized, Controlled Trials;Recovery;recruit;reduce symptoms;remote delivery;Research;resilience;response;satisfaction;Services;Severities;Severity of illness;skills;social;social culture;Social Development;Social isolation;social stigma;Social support;Societies;sociodemographic factors;Stress;symptomatic improvement;Symptoms;Systems Theory;telehealth;Testing;Training;Transportation;Treatment outcome;treatment response;Underserved Population;United States Substance Abuse and Mental Health Services Administration;Videoconferencing;Vocation;Youth

PROJECT_TITLE: Telehealth Adaptation of Group and Family-Based Cognitive Behavioral Therapy for Youth at Risk for Psychosis


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: LONG BEACH

ORG_NAME: CALIFORNIA STATE UNIVERSITY LONG BEACH

PHR: PROJECT NARRATIVE Low-income women experience several psychosocial stressors during pregnancy (e.g., poverty, discrimination) that place them at disproportionately higher risk of experiencing prenatal health complications and adverse birth outcomes that can lead to significant long- term health problems for mothers and their infants. This project will address this critical public health problem by providing new insight to the risk factors associated with the intergenerational transmission of stress outcomes from mothers to their children, particularly among low-income families experiencing chronic stressors related to socioeconomic adversity, family instability, and discrimination. This study will extend previous research on fetal programming by prospectively examining the effects of prenatal maternal and fetal cortisol levels, genetic factors (i.e., 5-HTTLPR genotype), and exposure to chronic stressors on changes in infant telomere length (a biological measure of disease risk) over time to identify potential avenues for prevention and treatment, as well as optimize health outcomes for mothers, their children, and subsequent generations.

PI_NAMEs: URIZAR, GUIDO G. (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: Acceleration;adverse birth outcomes;Affect;Alleles;American College of Obstetricians and Gynecologists;Biological;Biological Aging;Biological Markers;Biological Sciences;Birth;Birth length;brain cell;cell injury;Characteristics;Child;Child Rearing;Childbirth;Childhood;Chronic;Chronic stress;Cognitive;critical period;Data;delivery complications;Development;Discrimination;disorder risk;DNA;Emotional;Environment;environmental stressor;experience;Exposure to;Family;fetal;Fetal Development;fetal programming;Fetus;Generations;Genes;Genetic;Genetic Markers;Genotype;Hair;hands on research;Health;Health behavior;Health education;high risk;Hormones;Hydrocortisone;improved;Infant;Infant Health;innovation;insight;intergenerational;Length;Life;Low income;lower income families;Maternal Exposure;Maternal Health;maternal outcome;Measures;Mentors;Methodology;Mothers;neurodevelopment;offspring;Outcome;Pattern;Placenta;Population;Populations at Risk;postnatal;Postpartum Depression;postpartum health;postpartum outcome;Postpartum Period;Poverty;Pregnancy;Pregnancy Complications;Pregnant Women;Premature Birth;prenatal;prenatal experience;prenatal health;prenatal stress;Prevention;Principal Investigator;prospective;Psychoneuroendocrinology;psychosocial stressors;Public Health;recruit;Research;Research Activity;Research Personnel;Research Training;response;Risk;Risk Factors;Saliva;saliva sample;Salivary;serotonin transporter;socioeconomic adversity;Stress;stressor;student participation;student training;Students;telomere;Telomere Shortening;Testing;Time;Training Programs;transmission process;Underrepresented Students;underserved community;Universities;Woman;Work

PROJECT_TITLE: Intergenerational Effects of Stress among Low-Income Pregnant Mothers & their Infants


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_DEPT: PHYSIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE The proposed work will elucidate how proteolytic fragments derived from juncophilin-2 contribute to cellular remodeling associated with the development of ischemic heart disease.

PI_NAMEs: WEHRENS, XANDER H.T. (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: Acceleration;Affect;Alternative Splicing;Area;Binding;C-terminal;calmodulin-dependent protein kinase II;Calpain;Cardiac;Cardiac Myocytes;Cause of Death;Cell membrane;Cell Nucleus;Co-Immunoprecipitations;Complex;Coupling;Data;Development;disabled;Disabling;Disease;disease model;DNA;Ensure;Enzymes;Experimental Models;Failure;Genetic Transcription;Goals;Heart;Heart failure;improved;in vivo;Injury;Ischemia;ischemic injury;junctophilin;Knock-in Mouse;Lead;Length;link protein;m-calpain;Mediating;Modeling;Molecular;mouse model;mRNA Precursor;Mus;Mutation;Myocardial;Myocardial Infarction;Myocardial Ischemia;N-terminal;novel;Nuclear;Nuclear Localization Signal;Nuclear Translocation;overexpression;Patients;Peptides;Physiological;prevent;Protein Isoforms;Proteins;Proteolysis;Reperfusion Injury;Reperfusion Therapy;RNA;RNA Splicing;Role;Sarcoplasmic Reticulum;Site;SRSF2 gene;stress reduction;Structural Protein;Testing;United States;Ventricular Remodeling;Work

PROJECT_TITLE: Junctophilin-2 cleavage in ischemic heart disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MIM-R(01)]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: BIRMINGHAM

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE: Streptococcus pneumoniae (Spn) gains access to the heart during invasive pneumococcal disease. Subsequent uptake of pneumococci by cardiomyocytes results in host-cell death, aberrant cardiac function, and cardiac remodeling in survivors. This project explores the role of LC3-associated phagocytosis, a form of autophagy, in cardiomyocyte self-defense against intracellular Spn and resiliency against Spn-induced cardiac damage.

PI_NAMEs: ORIHUELA, CARLOS J (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Acute;Admission activity;Adult;Ampicillin;Animals;Antibodies;antimicrobial;Arrhythmia;Autophagocytosis;Bacteria;Blood Circulation;capsule;Cardiac;Cardiac Myocytes;cardiac tissue engineering;Cardiovascular system;Cell Death;Cells;Central Nervous System;Cessation of life;Clathrin;Collagen;community acquired pneumonia;Convalescence;Deposition;Disease;Echocardiography;Endocytosis;Event;experience;Future;Gram-Positive Bacteria;Heart;heart damage;Heart failure;heart function;Hospitalization;Hour;Hydrogen Peroxide;Image;Impairment;In Vitro;in vivo;Incidence;Individual;induced pluripotent stem cell derived cardiomyocytes;Infection;Intervention;Invaded;Knockout Mice;Laboratories;Lesion;Link;Mediating;middle ear;Molecular;mortality;Mus;Myocardial Infarction;Myocardium;novel;Organ;Papio;pathogen;Patients;Phagocytosis;Pneumococcal Infections;Pneumonia;Production;Research Personnel;resilience;Risk;Role;Sirius Red F3B;Stains;Streptococcus pneumoniae;Streptococcus pneumoniae plY protein;Survivors;Testing;Time;Tissue constructs;Tissue Microarray;Tissues;Troponin;uptake

PROJECT_TITLE: Cardiomyocyte self-defense against Streptococcus pneumoniae

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-Q(02)]


ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative Osteoarthritis (OA) is the most common form of arthritis and the primary cause of disability in the US. We identified a novel signaling pathway for TGF-ß acting through post-translational modification of the transcription factor Sox9. These highly mechanistic studies will enhance our current knowledge of how cartilage is maintained and provide new novel cartilage specific targets for drug discovery.

PI_NAMEs: SERRA, ROSA A. (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Arthritis;articular cartilage;Binding;Binding Proteins;Biological;Biological Assay;Biological Process;Bioreactors;Cartilage;cartilage degradation;Cells;Centers for Disease Control and Prevention (U.S.);Chondrocytes;chondroprotection;chromatin immunoprecipitation;CRISPR/Cas technology;Cyclic AMP-Dependent Protein Kinases;Degenerative polyarthritis;Development;disability;Disease;DNA;Dominant-Negative Mutation;drug discovery;Drug Targeting;Drug usage;Elements;Engineering;experimental study;Extracellular Matrix Proteins;Funding;Future;gain of function;Gel;Gene Expression;Gene Expression Regulation;Genes;genetic manipulation;Genetic Transcription;Half-Life;high throughput screening;Homeostasis;Human;In Vitro;Industrialization;joint function;Knock-out;Knowledge;Laboratories;loss of function;Luciferases;Maintenance;Maps;Mass Spectrum Analysis;Mediating;Messenger RNA;Modeling;Modification;Molecular;Mus;mutant;Mutation;novel;p38 Mitogen Activated Protein Kinase;parathyroid hormone-related protein;Pathway interactions;Peptides;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphorylation;Phosphorylation Site;Polysaccharides;polysulfated glycosaminoglycan;Post-Translational Modification Site;Post-Translational Protein Processing;Post-Translational Regulation;prevent;Proteins;Proteoglycan;Regulation;Reporter;response;Role;Serine;sex;Signal Pathway;Signal Transduction;Site;Skeletal Development;skeletal disorder;skeletal tissue;stable cell line;Stains;Sulfate;Sumoylation Pathway;TGFBR2 gene;Tissue-Specific Gene Expression;Tissues;transcription factor;Transforming Growth Factor beta;Transgenic Mice;Western Blotting

PROJECT_TITLE: Mechanism of Tgfbr2 in Chondroprotection

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ORG_CITY: MINNEAPOLIS

ORG_NAME: MINNEAPOLIS VA  MEDICAL CENTER

ORG_STATE: MN

PHR: Viral and bacterial infection has emerged as an urgent threat to our aged population, including Veterans. Aging affects us all and brings increased risk of morbidity and mortality, depleting quality of life, and elevating susceptibility to viral pathogens. Recent evidence indicates that damaged, senescent (dying) cells drive aging and age-related morbidity, and adverse outcomes upon acute exposure to pathogens. In this application, we will test the hypothesis that clearing senescent cells from aged, obese and brain compromised (dying brain cells) mice using senolytic drugs (to remove dying cells) protects against morbidity and mortality upon exposure to community acquired viral pathogens. This study will be a proof of concept to use senolytic drugs such as fisetin to prevent and treat viral infection induced complications in patients who are aged, have obesity and/or are suffering from neurodegenerative disorders such as Parkinson's disease.

PI_NAMEs: KOTZ, CATHERINE M (contact)

PROJECT_TERMS: Acute;Adult;adverse outcome;Affect;Age;age related;age related chronic disease;age-related disease;aged;Aging;aging mechanism;aging population;aging related;alpha synuclein;animal old age;Automobile Driving;Bacterial Infections;Beds;Behavior;Brain;brain cell;burn pit;cell age;Cell Aging;Cells;Chronic Disease;Clinical Trials;Cognition;Cognitive;cognitive ability;Cognitive deficits;Communities;Community-Acquired Infections;Coronavirus;current pandemic;cytokine release syndrome;Dasatinib;Data;drivers of aging;Elderly;emerging pathogen;experience;Exposure to;fisetin;Flavonoids;Fostering;frailty;fruits and vegetables;germ free condition;Geroscience;Goals;Health;Healthcare Systems;high risk;Histopathology;House mice;Human;human old age (65+);improved;In Vitro;in vivo;Individual;Infection;infection risk;Inflammatory;Inflammatory Response;Knowledge;Laboratory mice;life span;Link;Mediating;microbial;military service;military veteran;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Natural Products;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;novel;Nutraceutical;Obese Mice;Obesity;old mice;pandemic disease;Parkinson Disease;pathogen;pathogen exposure;pathogenic bacteria;pathogenic virus;Patients;Pattern;Persons;Pharmaceutical Preparations;Physical activity;Physical Function;Physiological;pre-clinical;Predisposition;prevent;promote resilience;Quality of life;Quercetin;Reproducibility;resilience;Resistance;Resources;Risk;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Specific qualifier value;stressor;synucleinopathy;Testing;therapeutic target;Tissues;Transgenic Model;transmission process;Trauma;Veterans;Virus Diseases;Vulnerable Populations

PROJECT_TITLE: Fisetin as a treatment for community-acquired pathogen susceptibility during aging, obesity and neurodegenerative diseases


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Kidney Disease;Nanotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it is aimed at improving rates of arteriovenous fistula (AVF) maturation and long-term patency for patients with end-stage renal disease requiring hemodialysis. This study supports our long term-goal of understanding the mechanism in the pathogenesis of non-maturing AVFs and develop absorbable, imaging-capable medical devices that could modulate neointimal hyperplasia. Furthermore, development of an imaging technique based on combined ultrasound/photoacoustic (US/PA) and positron emission tomography (PET) imaging will assist with AVF monitoring and lead to an improved understanding of AVF maturation/non-maturation with potential for the development of novel therapeutic interventions.

PI_NAMEs: MELANCON, MARITES PASUELO (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: accurate diagnosis;Address;Adventitious Tissue;Adverse reactions;Animal Model;Anti-Inflammatory Agents;Arteriovenous fistula;arteriovenous graft;biodegradable polymer;Blood Vessels;Catheters;CCL2 gene;Cells;Chronic Kidney Failure;Clinical Trials;cytokine;Data;Death Rate;design;Development;Device or Instrument Development;Devices;Diameter;Dilatation - action;drug development;Electrospinning;End stage renal failure;Endothelium;Engineering;Environment;Failure;Family suidae;Goals;Hemodialysis;hemodynamics;Histology;Homeostasis;Human;Hyperplasia;Hypoxia;Iatrogenesis;Image;image guided;imaging capabilities;imaging modality;Imaging Techniques;implantation;improved;In Vitro;in vivo;Inflammation;Inflammatory;innovation;Legal patent;Lesion;Measures;Mechanics;Mediator;Medical Device;Medical Imaging;Mesenchymal Stem Cell Transplantation;Mesenchymal Stem Cells;migration;Modeling;Monitor;Morbidity - disease rate;mortality;nanoparticle;Natural regeneration;non-invasive imaging;non-invasive monitor;novel;novel therapeutic intervention;Operative Surgical Procedures;optoacoustic tomography;Oxygen;Pathogenesis;Pathologic;Patients;photoacoustic imaging;Physiological;Polymers;porcine model;Positron-Emission Tomography;prevent;Property;Public Health;Radiology Specialty;Rattus;Recommendation;repaired;Research;response;Role;Safety;scaffold;shear stress;Solvents;Source;stem cell delivery;Stenosis;Stress;Structure;System;systemic toxicity;Testing;Therapeutic;Therapeutic Intervention;Thick;Thrombosis;Time;Tissues;Toxic effect;treatment strategy;Ultrasonography;ultrasound;United States;Uremia;vascular injury;Veins;Venous;Viscosity;Visualization;Work;X-Ray Computed Tomography

PROJECT_TITLE: Biodegradable Radiopaque Polymeric Scaffolds Loaded with Mesenchymal Stem Cells for Image-Guided Arteriovenous Fistula Maturation and Long-Term Patency

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]