NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE More than six million Americans and 30 million people worldwide are living with Alzheimer’s disease (AD), yet patients do not have any treatments to definitively cure AD or slow its progression. AD is associated with toxic aggregation of the protein tau, so our group has determined atomic-resolution structures of tau and designed structure-based inhibitors to halt its aggregation. We are investigating the therapeutic potential of targeting tau in AD by studying these inhibitors in a mouse model of tau aggregation.

PI_NAMEs: PAN, HOPE  (contact)

PROGRAM_OFFICER_NAME: GROTHAUS, PAUL G

PROJECT_TERMS: Address;Adult;Affect;Affinity;Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease therapeutic;American;Amino Acid Sequence;Amino Acids;Amyloid beta-Protein;analog;Autopsy;Behavioral;Binding;Binding Proteins;Biosensor;Blood - brain barrier anatomy;blood-brain barrier penetration;blood-brain barrier permeabilization;Brain;brain parenchyma;Cell model;Cells;cerebral atrophy;Cessation of life;Crystallization;Data;Dementia;design;Disease Progression;Enzymes;experience;Goals;Half-Life;high throughput screening;Human;human old age (65+);Immunohistochemistry;Impaired cognition;improved;In Vitro;in vivo;inhibitor;insight;Investigation;LDL-Receptor Related Protein 1;Link;Measures;Memory Loss;Micro Electron Diffraction;Microtubules;mild cognitive impairment;Modification;mouse model;Mus;Nerve Degeneration;neurofibrillary tangle formation;Neurofibrillary Tangles;neuron loss;novel therapeutics;Pathology;Patients;peptide drug;Peptides;Peripheral;Persons;Plasma;prevent;protein aggregation;Proteolysis;receptor mediated endocytosis;Resistance;Resolution;Senile Plaques;Structure;tau aggregation;tau Proteins;Tauopathies;Therapeutic;tomography;Transgenic Mice;Treatment Efficacy;Visualization;X ray diffraction analysis

PROJECT_TITLE: Designing novel therapeutics for Alzheimer’s disease using structural studies of tau


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BRONX

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHOLOGY

ORG_FIPS: US

ORG_NAME: FORDHAM UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE HIV remains a major public health problem, particularly for the US Latina/o population who is at increased risk for HIV-infection compared to non-Hispanic whites, and suffer a disproportionate burden of HIV-associated neurocognitive disorder (HAND), which may be amplified with age. Utilizing a biopsychosociocultural theoretical framework, the proposed multidisciplinary study will investigate whether older HIV+ Latinas/os of Puerto Rican origin demonstrate greater declines in cognition and brain integrity compared to other ethnic/HIV status groups, and to examine the biological (e.g., neuroinflammatory biomarkers [sTREM2, sCD14, sTNFR-II, & IL-6] and cardiovascular burden) and sociocultural (e.g., acculturation, social adversity, stress) mechanisms increasing risk for neurodegenerative and cognitive changes in this population. Addressing dementia and HAND health disparities in Latinas/os is vital for public health to: 1) improve our understanding of biological and sociocultural aspects of neurosenescence and cognitive aging through the lens of HIV infection; 2) advance dementia research in other conditions (e.g., Alzheimer’s Disease [AD] & related dementias [ADRDs]) by offering greater understanding of sociocultural variations in the neuropathogenesis of dementia; 3) inform culturally-relevant and targeted interventions that could lead to better Latina/o cognitive and health outcomes in HIV and other chronic conditions that disproportionately burden this population (e.g., AD, ADRDs); and 4) provide a framework for studying and addressing dementia and HAND in Latin American countries that also bear a heavy HIV burden.

PI_NAMEs: RIVERA-MINDT, MONICA G. (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Acculturation;Address;Adult;advanced dementia;Affect;African American population;Age;age related;aged;Aging;aging population;aging related disease;Alzheimer's Disease;Alzheimer's disease related dementia;Attention;Biological;Biological Factors;Biological Markers;Biological Models;Brain;brain health;brain magnetic resonance imaging;Cardiovascular system;cerebrovascular;Chronic;Cognition;Cognitive;Cognitive aging;cognitive change;cognitive function;comorbidity;Country;culturally appropriate intervention;cytokine;Data;Dementia;design;Disparate;Disparity;Equation;ethnic disparity;Ethnic Origin;executive function;Goals;gray matter;Health;health disparity;health equity;High Prevalence;high risk;Hippocampus;HIV;HIV Infections;HIV-associated neurocognitive disorder;Impaired cognition;Impairment;improved;indexing;Inflammation;Interleukin-6;Intervention;Laboratories;Latin American;Latina;Latina Population;Latino Population;Learning;lens;Lesion;Literature;Magnetic Resonance Imaging;medial temporal lobe;Memory;Mexican Americans;Modeling;Morbidity - disease rate;multidisciplinary;multimodal neuroimaging;Nerve Degeneration;neural;neuroimaging;neuroinflammation;Neuropathogenesis;Not Hispanic or Latino;older adult;Outcome;Participant;Pattern;personalized approach;poor health outcome;Population;Predisposition;processing speed;Public Health;Puerto Rican;Research;Risk;Risk Factors;risk mitigation;Sampling;Scientist;Severities;Severity of illness;social adversity;social culture;sociocultural determinant;Stress;Structure;Testing;Variant;white matter;Work

PROJECT_TITLE: Study of Aging Latinas/os for Understanding Dementia in HIV (SALUD HIV)

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Narrative This grant supports innovative training of 14 Ph.D. students in Genetics and Developmental Biology at Stanford University, an interdisciplinary program that bridges different departments and prepares our students to carry out innovative, rigorous research and become leaders in academia and industry. Outstanding faculty and trainees combine new methods and diverse study systems to advance our mechanistic understanding of genes, cells, tissues, organs, organisms, and human health and disease. These advances have spurred on the biotechnology and biopharmaceutical industries that have ultimately led to improved clinical care and health outcome for millions of patients.

PI_NAMEs: FULLER, MARGARET T;SHERLOCK, GAVIN J (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TITLE: Genetics and Developmental Biology Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Per PAR-21-321 instructions, this component is not required.

PI_NAMEs: SHULL, JAMES D (contact)

PROJECT_TERMS: Advanced Malignant Neoplasm;Award;Basic Science;Biotechnology;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genetics;cancer prevention;cancer research center director;Charge;Church;Clinical;Communities;Comprehensive Cancer Center;Cost Analysis;cost effective;cost effectiveness;Data;Direct Costs;Epigenetic Process;Equipment;Evaluation;experience;Faculty;Fee Schedules;Fees and Charges;Financial Support;Funding;Funding Agency;Graduate Education;Health Services Accessibility;Infrastructure;Institution;Instruction;Investments;Leadership;Malignant Neoplasms;Marketing;Mediation;medical schools;member;Mission;National Cancer Institute;NCI Center for Cancer Research;operation;Population Research;Population Sciences;Process;programs;Public Health;quality assurance;Quality Control;Reporting;Reproducibility;Research;Research Infrastructure;Research Project Grants;Resource Sharing;Schedule;Secure;Services;Source;Surveys;tool;Universities;Vendor;virtual;Wisconsin;Work

PROJECT_TITLE: Shared Resource Management

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: HOUSTON

ORG_NAME: MICHAEL E DEBAKEY VA MEDICAL CENTER

ORG_STATE: TX

PHR: This research program will study the mechanisms of formation of blood clots in tiny blood vessels. These blood clots contribute to organ dysfunction in critically ill patients with Coronavirus 2019 (COVID-19) and with sepsis, the body’s response to an infection. COVID-19 and sepsis are common and significant problems in intensive care in the VA system and patients with severe cases of these conditions have high mortality. The causes of blood clots in tiny vessels in sepsis and COVID-19 are unclear, and there is no specific treatment available. The proposed work will help clarify how these blood clots develop in sepsis and COVID-19, with the long-term goal of developing new treatment options to improve the outcome of Veterans with these devastating conditions.

PI_NAMEs: RUMBAUT, ROLANDO E (contact)

PROJECT_TERMS: 2019-nCoV;Acute;Admission activity;Adult;airway inflammation;animal data;Animal Model;Blood coagulation;Blood Coagulation Disorders;Blood Vessels;Cause of Death;Cell surface;cell type;Cells;clinically significant;Coronavirus;COVID-19;Critical Care;Critical Illness;Cytoplasm;Data;Death Rate;Diagnosis;Disease;Economic Burden;effective therapy;Endothelial Cells;Endotoxemia;experimental study;extracellular;Fibrin;Functional disorder;Future;glycosylation;Goals;Healthcare Systems;Hospitalization;improved outcome;Individual;Infection;Inflammation;Inflammatory;Intensive Care;Intensive Care Units;interest;Knowledge;Laboratories;Life;Link;Mediating;Mediator;Medical center;Medicine;military veteran;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;new therapeutic target;novel;Organ;Patients;Phosphorylation;Plasma;Play;polymerization;Polymers;polymicrobial sepsis;Post-Translational Protein Processing;prevent;programs;Proteins;Research;response;Role;Sepsis;Severities;Sickle Cell Anemia;System;systemic inflammatory response;Techniques;Therapeutic;Thrombin;thromboinflammation;Thrombosis;Thrombotic Thrombocytopenic Purpura;Thrombus;Tissue Model;United States;Veterans;Vimentin;Work;wound healing

PROJECT_TITLE: Mechanisms of microvascular thrombosis in inflammation


ORG_CITY: CHICAGO

ORG_NAME: JESSE BROWN VA MEDICAL CENTER

ORG_STATE: IL

PHR: The World Health Organization names depression as the leading cause of disability, worldwide. Depression and suicide are particularly prevalent in military returning from deployment and the population of Veterans they become. As many as one third are resistant to antidepressants and they are at greatest risk for suicide. We will use cultured cells and patient-derived neural stem cells to screen new compounds with potential antidepressant activity and attempt to identify common molecular themes among antidepressants. We will also determine whether these molecular signatures are observed in blood cells from depressed and treated patients. Knowledge gained from this study should help to develop a rapid and inexpensive screen for antidepressant responsiveness, allowing changes in therapy long before the current 4-6 week lag time.

PI_NAMEs: RASENICK, MARK M. (contact)

PROJECT_TERMS: Adenylate Cyclase;Animal Model;anti-depressive agents;antidepressant effect;Autopsy;Biochemical;Biological Markers;Biology;biosignature;Blood Cells;Blood Platelets;Brain;Brain-Derived Neurotrophic Factor;Cell Fraction;Cell Line;Cells;Cementation;Chemicals;Chimeric Proteins;Chronic;Clinical;completed suicide;Coupling;CREB1 gene;Cultured Cells;Cyclic AMP;Data;deacylation;Depressed mood;Depressive disorder;disability;Disease remission;Dissociative Anesthetics;Event;Fright;Funding;GTP-Binding Protein alpha Subunits, Gs;Hallucinogens;Hamilton Rating Scale for Depression;Heterotrimeric GTP-Binding Proteins;Human;In Vitro;Individual;Induced Neurons;insight;Ketamine;Knowledge;Link;Liquid substance;Measures;Membrane;Membrane Microdomains;Mental Depression;Military Personnel;military veteran;Molecular;Molecular Profiling;Movement;Names;nerve stem cell;Neuroglia;Neurons;novel;novel diagnostics;novel therapeutics;palmitoylation;Pathway interactions;Patients;Peripheral;Pharmaceutical Preparations;postsynaptic;presynaptic;Production;Property;Rapid screening;Research;Resistance;response;Role;Sampling;Screening procedure;service member;side effect;Site;social stigma;Speed;suicidal risk;Suicide;System;Therapeutic;Time;Tissues;Translations;treatment duration;treatment response;Tubulin;uptake;Veterans;Work;World Health Organization

PROJECT_TITLE: Lipid raft localization of Gs: a biomarker for depression and therapeutic response


ORG_CITY: SAN ANTONIO

ORG_NAME: SOUTH TEXAS VETERANS HEALTH CARE SYSTEM

PHR: Post-traumatic Stress Disorder (PTSD) and co-morbid depression are serious illnesses afflicting the veteran population. Current treatments are inadequate, and there is a need to identify new therapeutic approaches, but progress has been hindered by a lack of understanding of neural mechanisms underlying the pathology of these disorders and their effective treatment. Behavioral therapies, including exposure therapy, are alternatives to drug therapies, but little is known of their mechanisms. We have established extinction learning as a model of exposure therapy in rats, showing beneficial effects in restoring stress-induced impairments in cognition and coping behavior that resemble aspects of PTSD and depression. The purpose of this proposal is to identify the neural mechanisms underlying these effects, and to test a novel adjunct approach combining a new therapeutic drug candidate with extinction to see if it can enhance the efficacy of extinction. The results should inform the future development and implementation of novel strategies to improve treatment of these illnesses.

PI_NAMEs: MORILAK, DAVID A (contact)

PROJECT_TERMS: Acoustics;Affective;Afferent Pathways;Aftercare;Amygdaloid structure;Anhedonia;Animal Model;associated symptom;Attention;Beds;behavior measurement;Behavior Therapy;Behavioral;behavioral response;Brain region;Brain-Derived Neurotrophic Factor;Cell Nucleus;Chronic;Chronic stress;Cognition;Cognitive;Collaborations;Combined Modality Therapy;comorbid depression;comorbidity;Coping Behavior;designer receptors exclusively activated by designer drugs;Development;Dimensions;Disease;Dose;Down-Regulation;drug candidate;effective therapy;efficacy testing;evidence base;Extinction;Family;flexibility;Future;GABA-A Receptor;Goals;Grant;Healthcare;high risk;Hippocampus;Hour;Impairment;improved;Investigation;Ketamine;Knowledge;Lateral;learning extinction;Measures;Medial;Mediating;Mental Depression;Mental disorders;Microinjections;military veteran;Modality;Modeling;negative affect;neural;neural circuit;neurobiological mechanism;Neurobiology;neuromechanism;neutralizing antibody;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Nucleus Accumbens;Pathology;pharmacologic;Pharmacological Treatment;Pharmacotherapy;Physiological;Play;Post-Traumatic Stress Disorders;preference;Prefrontal Cortex;Process;Productivity;Protein Biosynthesis;Protocols documentation;Psychopharmacology;Psychotherapy;Quality of life;Rattus;Recording of previous events;Research;Research Personnel;response;Role;Signal Induction;Signal Pathway;Signal Transduction;Stress;Stress and Coping;success;Sucrose;System;targeted agent;Testing;Thalamic structure;Therapeutic;Therapeutic Agents;Therapeutic Effect;therapeutic evaluation;therapeutically effective;Treatment Efficacy;treatment response;treatment strategy;ventral visual stream;Veterans

PROJECT_TITLE: Treating PTSD and depression: Mechanisms of pharmacotherapy and psychotherapy in rats


ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

ORG_STATE: MA

PHR: The proposed project is relevant to bleeding, particularly in trauma or surgery. The results are also relevant for understanding the relationship of inflammation to blood coagulation, including the vascular pathology of COVID-19.

PI_NAMEs: GILBERT, GARY E (contact)

PROJECT_TERMS: activated Protein C;Anticoagulants;Anticoagulation;Attenuated;attenuation;Binding;Biological Assay;Biophysics;Blood;Blood Cells;Blood coagulation;Blood Coagulation Disorders;Blood Platelets;Blood Vessels;Bulla;Bypass;Cell membrane;Cells;Cellular biology;Childbirth;Clinical;Coagulation Process;cofactor;Collagen;Complex;Confocal Microscopy;COVID-19;Defect;Detection;Disseminated Intravascular Coagulation;Endothelial Cells;Endothelium;Engineering;Environment;enzyme activity;Enzymes;Evaluation;experience;Factor V;Factor VIIa;Factor Xa;Factor XIa;Filopodia;Flow Cytometry;Gene Modified;genetic regulatory protein;Hemophilia A;Hemorrhage;Hemostatic Agents;Hemostatic function;Human;Impairment;In Vitro;Individual;Inflammation;inhibitor;injured;innovation;insight;Knowledge;Laboratories;Location;Measures;Mediating;Membrane;Methodology;Methods;Microfluidics;Modeling;Mucous Membrane;Multienzyme Complexes;Mus;novel;Operative Surgical Procedures;Pathology;Pathway interactions;Patients;Peptide Hydrolases;Phosphatidylserines;Phospholipids;Plasma;Plasmin;Pore Proteins;Prevention;Protein S;Proteins;Reaction;Regulation;response;Scott syndrome;Spatial Distribution;Stress;Surgical Hemostasis;Tail;Testing;TFPI;Therapeutic;Thrombin;Thromboplastin;Time;Tissues;Trauma;Umbilical vein;vascular inflammation;vascular injury;Vesicle;Visualization;Work

PROJECT_TITLE: Endothelial topography, phosphatidylserine, and procoagulant activity


ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Malaria remains one of the deadliest diseases in the world today, as it has been so for thousands of years. For each of the half a million people killed annually there are hundreds that are severely sickened by malaria. Indeed, malaria is one of the most frequent causes of sickness and death in the world today but especially in sub-Saharan Africa where its victims are primarily young children, babies and pregnant women. And the situation is worsening due to the emergence of strains that harbor resistance to multiple drugs, including chloroquine and amodiaquine. As a result, there is an urgent need to develop an effective replacement for chloroquine that is rapidly active and safe enough for use in children and pregnant women. The derivatives described herein have the potential to fulfill this need and to have a major impact on global health. The resultant advantages of avoiding drug toxicity, febrile illness and complex medical management during deployment are self-evident, as are the benefits to both short and long-term health of the US soldier.

PI_NAMEs: RISCOE, MICHAEL KEVIN (contact)

PROJECT_TERMS: 4-aminoquinoline;Acceleration;Africa South of the Sahara;American soldier;Amodiaquine;Anti-malarials;Artemisinins;artesunate;Attention;Award;Binding;Biological;Blood;Budgets;Cardiac;Cardiotoxicity;Cessation of life;Chemical Exposure;Chemoprevention;Child;Chloroquine;Chloroquine resistance;Clinical;clinically relevant;combat readiness;combat veteran;Complex;Cresol;cytotoxicity;design;Development;Disease;drug action;Drug Kinetics;Drug Metabolism Induction;Drug toxicity;efficacy trial;Exhibits;experience;Fever;Future;global health;Glucosephosphate Dehydrogenase Deficiency;Goals;Health;Hemolytic Anemia;Human;improved;In Vitro;in vitro activity;in vivo;Individual;Infection;Knowledge;Lead;lead candidate;Learning;Legal patent;Malaria;Mammalian Cell;Mannich Bases;Mediating;Medical;Mefloquine;member;Metabolic;Microsomes;Modeling;Modification;morpholine;mouse model;Multi-Drug Resistance;Mus;Neurologic;novel;novel therapeutics;Oral;Oral Administration;Parasites;Persons;Pharmaceutical Preparations;Plasmodium falciparum;Plasmodium vivax;Positioning Attribute;pre-clinical;preclinical development;Preclinical Testing;Pregnant Women;prevent;Prodrugs;Prophylactic treatment;Publishing;Quinine;quinoline;Recording of previous events;Reporting;Resistance;resistant strain;Risk;Risk Assessment;Rodent;Rotation;Route;Safety;scaffold;Series;Side;side effect;Strategic Planning;Stress;success;System;Testing;Therapeutic;Therapeutic Intervention;Time;Toxic effect;Toxicant exposure;transmission blocking;Veterans;Vivax Malaria;Vulnerable Populations;warfighter;Work

PROJECT_TITLE: Pharmachin Optimization and Testing


PI_NAMEs: BAILEY, HOWARD H. (contact)

PROJECT_TERMS: Acceleration;Accountability;Achievement;Address;Advocacy;Area;Articulation;Basic Science;Biological Markers;Cancer Center;Cancer Center Support Grant;cancer research center director;Caring;Catchment Area;Characteristics;clinical care;Clinical Oncology;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;community engagement;community organizations;community partners;Comprehensive Cancer Center;Consensus;County;Decision Making;Education;Elements;Employee;Ensure;Environment;equity, diversity, and inclusion;Ethnic Origin;Evaluation;Faculty;Family;Focus Groups;Fostering;Funding;Future;Genomic medicine;Goals;Grant;Growth;Health system;Image;improved;Individual;Industry;Informatics;innovation;Instruction;Leadership;Malignant Neoplasms;medical schools;meetings;member;Mission;NCI-Designated Cancer Center;Not Hispanic or Latino;novel;oncology service;Outcome;outreach;Patients;peer;Peer Review;Persons;Physician Executives;Population;Population Sciences;precision medicine;Prevention;Process;Productivity;programs;prospective;Public Health;Race;recruit;Research;Research Personnel;Resource Sharing;Resources;Role;Science;Scientist;Services;Strategic Planning;Students;success;Surveys;Teacher Professional Development;Technology;Therapeutic Intervention;Training and Education;Translational Research;Translations;Underrepresented Populations;Universities;Vision;Wisconsin;Work

PROJECT_TITLE: Leadership, Planning and Evaluation


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Foodborne Illness;Hematology;Infectious Diseases

ORG_CITY: INDIANAPOLIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative The causative agent of toxoplasmosis, Toxoplasma gondii, is currently reported by the CDC as one of the leading causes of foodborne-related deaths in the Unites States. Moreover, current regimens to treat toxoplasmosis are clinically repurposed medicines with high rates of toxicity. Hence, determining how T-bet regulates myeloid cell anti-parasitic mechanisms is critical to identify novel treatment therapies that are specifically targeted to T. gondii.

PI_NAMEs: LOPEZ-YGLESIAS, AMERICO HARRY (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Acute;acute infection;adaptive immune response;Adoptive Transfer;Animals;antimicrobial;Antiparasitic Agents;B-Lymphocytes;CD4 Positive T Lymphocytes;cell type;Cells;Cessation of life;Clinical;conditional knockout;Congenital Toxoplasmosis;Cyst;cytokine;Cytometry;Defense Mechanisms;Development;experimental study;Fetus;Flow Cytometry;foodborne;Host Defense;Host resistance;Human;Immune;Immune response;Immune system;Immunity;Immunocompromised Host;Immunofluorescence Immunologic;in vivo;Individual;Infection;Interferon Type II;Interleukin-12;Invaded;ITGAX gene;Kinetics;Lymphocyte;Lymphoid Cell;Maps;Mediating;Medicine;Molecular;Molecular Biology Techniques;Morbidity - disease rate;mortality;mouse model;Mus;Mutant Strains Mice;Myelogenous;myeloid cell development;Myeloid Cells;novel;Parasites;Parasitic infection;pathogen;Population;Production;reconstitution;Regimen;Reporter;Reporting;Research;response;Role;side effect;single-cell RNA sequencing;Sorting;Splenocyte;T cell response;T-bet protein;T-Lymphocyte;targeted treatment;Testing;Therapeutic Intervention;therapeutic target;Time;Toxic effect;Toxoplasma gondii;Toxoplasmosis;United States;Up-Regulation

PROJECT_TITLE: T-bet-regulated myeloid innate defense against Toxoplasma gondii

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Clinical Research;Digestive Diseases;Food Allergies;Nutrition;Palliative Care;Pediatric;Prevention

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

PHR: PROJECT NARRATIVE The Prevention of Peanut Allergy (PPA) Guidelines offer a rare opportunity to prevent a chronic and life- threatening condition. As caregivers are the ultimate drivers of the PPA guideline implementation, furthering our understanding of caregiver needs and addressing them with novel interventions that support caregivers is needed. Completion of these studies will augment and strengthen our current food allergy prevention approach.

PI_NAMEs: SAMADY, WAHEEDA  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: 3 year old;acceptability and feasibility;Addendum;Address;Adherence;Affect;Age Months;Allergens;Allergic Disease;Allergic Reaction;Allergy to eggs;Allergy to peanuts;Automobile Driving;behavior test;Behavior Therapy;Behavioral Sciences;caregiver interventions;Caregiver support;Caregivers;Child;Childhood;Chronic;Clinic;Clinical;clinical decision support;combat;Data;Data Analyses;Development;Disease;Eczema;effectiveness evaluation;effectiveness study;Evaluation;experience;Exposure to;feeding;Focus Groups;Food;Food Hypersensitivity;Fright;Future;gastrointestinal system;Goals;Guideline Adherence;Guidelines;high risk infant;Horns;Illinois;Immune;Immune response;improved;infancy;Infant;Ingestion;Internet;Intervention;Interview;Knowledge;Learning;Life;Mentors;National Institute of Allergy and Infectious Disease;non-compliance;novel;nutritional guideline;parent grant;Pathway interactions;pediatrician;Physicians;pilot test;Prevalence;prevent;Prevention;Prevention approach;Prevention Guidelines;Prevention strategy;Process;promoter;Proteins;prototype;Public Health;Publishing;Qualitative Research;randomized, clinical trials;Reaction;Recommendation;Reporting;Research;Research Personnel;Risk;Science;skills;skin barrier;Social Network;support tools;Surveys;Testing;theories;Time;Training;Uncertainty;United States;uptake;willingness;Writing

PROJECT_TITLE: Infant Peanut Allergy Prevention: Understanding and Supporting Caregivers to Achieve Adherence

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Eczema / Atopic Dermatitis;Microbiome

ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

ORG_STATE: CO

PHR: PROJECT NARRATIVE In response to RFA-AI-19-014, the purpose of this grant application is to establish an Atopic Dermatitis Research Network-Leadership Center (ADRN-LC) at National Jewish Health (NJH). The ADRN-LC will provide the overall scientific strategy and organizational structure to the ADRN and will interact closely with the ADRN- Clinical Research Centers (ADRN-CRCs), to support the conduct of multi-site clinical studies and trials that will elucidate mechanisms of skin barrier dysfunction and cutaneous immune responses in atopic dermatitis (AD). These studies will include clinical intervention studies involving the microbiome and blockade of immune pathways as well as clinical mechanistic studies to define endotypes that distinguish persistent mild vs. persistent severe AD.

PI_NAMEs: LEUNG, DONALD YM (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Applications Grants;Area;Asthma;Atopic Dermatitis;atopy;Bacterial Infections;biobank;Biological;Birth;chronic inflammatory skin;Clinical;Clinical Research;Clinical Trials;Cohort Studies;Collaborations;Communication;Cutaneous;Data Coordinating Center;data integrity;Defect;design;Development;dysbiosis;Ensure;Epithelium;evidence base;follower of religion Jewish;Food Hypersensitivity;Functional disorder;Funding;General Population;Goals;Grant;Health;Hospitalization;Host Defense;Hypersensitivity;Immune;Immune response;Immunity;Impairment;Inflammation;Infrastructure;Interleukin-1;Interleukin-13;Interleukin-4;Intervention;Intervention Studies;Leadership;lipidomics;Long-Term Effects;microbial;microbiome;microbiota transplantation;Morbidity - disease rate;Multi-site clinical study;National Institute of Allergy and Infectious Disease;novel;novel strategies;Observational Study;operation;Operations Research;organizational structure;Outcome;Pathway interactions;Patients;Performance;Phenotype;programs;Proteomics;Protocols documentation;Quality of life;Research;Research Personnel;Resources;response;rho;safety study;Sampling;single-cell RNA sequencing;Skin;skin barrier;skin disorder;skin microbiome;Structure;Study Subject;systemic inflammatory response;Systems Biology;targeted treatment;Therapeutic Intervention;Time;Topical Corticosteroids;transcriptomics;Translating;treatment response;United States National Institutes of Health;Virus Diseases;Work

PROJECT_TITLE: ATOPIC DERMATITIS RESEARCH NETWORK LEADERSHIP CENTER


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Precision Medicine

PI_NAMEs: WISINSKI, KARI BRAUN (contact)

PROJECT_TERMS: adjudication;anti-cancer research;Budgets;Cancer Center;Cancer Center Support Grant;cancer clinical trial;cancer health disparity;career;Career Choice;Career Mobility;Catchment Area;clinical care;Clinical Data;clinical infrastructure;Clinical Management;Clinical Oncology;Clinical Protocols;Clinical Research;Clinical Services;Clinical Trials;Collaborations;Communication;Communities;community collaboration;community engagement;Community Outreach;Comprehensive Cancer Center;Cost efficiency;data management;Data Reporting;data sharing;Dedications;design;Development;Disease;Early Therapeutic-Clinical Trials Network;Education;Enhancement Technology;Enrollment;Ensure;equity, diversity, and inclusion;Faculty;Feedback;Future;Genomics;Goals;Grant;Health;Immunotherapy;improved;Individual;Industrialization;Informatics;Infrastructure;innovation;Institution;Instruction;Intake;Internships;Intervention;Intervention Studies;Intervention Trial;investigator-initiated trial;Lead;Leadership;life span;Malignant Neoplasms;Medicine;member;minority patient;Mission;Molecular Medicine;Monitor;Oncology;oncology service;operation;outreach;Pathway interactions;patient oriented;Patients;Peer Review;Performance;Physician Executives;Policies;precision medicine;Precision medicine trial;Process;programs;Protocols documentation;quality assurance;Quality Control;rare cancer;Recommendation;Regulation;Research;Research Activity;research study;response;Risk;Rural Population;Services;Site;Strategic Planning;Structure;success;Surveys;System;Technology;theranostics;Time;timeline;Tissues;Training;Translations;treatment trial;tumor;Underrepresented Populations;Universities;Wisconsin;Woman;Work

PROJECT_TITLE: Clinical Protocol and Data Management


ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project Narrative – Indiana Alzheimer’s Disease Research Center The Indiana Alzheimer’s Disease Research Center (IADRC) is a multidisciplinary research program intensely committed to the U.S. National Alzheimer’s Project Act (NAPA) to prevent and effectively treat Alzheimer’s disease (AD) by 2025. Major activities include innovative research on causes, early detection, and treatment, including both pharmacological and non-drug approaches, as well as interventions for caregivers and educational programs for researchers and members of the community. The IADRC is part of a network of centers and programs working to rapidly find a cure for AD.

PI_NAMEs: SAYKIN, ANDREW J (contact)

PROGRAM_OFFICER_NAME: ELLIOTT, CERISE

PROJECT_TERMS: academic program;Acceleration;Address;advanced analytics;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Animal Model;Awareness;Biological;biological heterogeneity;Biological Markers;Biological Models;Brain;brain health;caregiver interventions;Caregivers;Clinical;clinical phenotype;Clinical Trials;Cognition;cognitive testing;cohort;Collaborations;collaborative approach;Communities;Complex;cost effective;Creativeness;Data;Data Science;Data Scientist;demented;Dementia;Development;Diagnosis;Discipline;Disease;Disparity;disparity reduction;DNA sequencing;dosage;early detection biomarkers;Early Diagnosis;Early Intervention;Education;effective therapy;Environment;Environmental Risk Factor;ethnoracial;Etiology;Family;Family member;Fostering;Functional disorder;Genetic;Goals;Growth;Healthcare;Heterogeneity;Image;Impaired cognition;improved;Indiana;Individual;induced pluripotent stem cell;Industry;Informatics;Inherited;innovation;Institution;Interdisciplinary Study;International;Intervention;Leadership;lifestyle factors;Machine Learning;Maps;medical schools;medical specialties;member;metabolomics;method development;Methodology;Methods;mild cognitive impairment;Molecular;Molecular Genetics;multimodal neuroimaging;multiple omics;Nature;Nerve Degeneration;neuropathology;new therapeutic target;non-drug;Nonpharmacologic Therapy;novel;novel diagnostics;novel strategies;Participant;Pathogenesis;Pathway interactions;Patients;Persons;pharmacologic;Phase;Phenotype;Population Heterogeneity;Positioning Attribute;Positron-Emission Tomography;pre-clinical;precision medicine;Prevalence;prevent;Prevention;Process;programs;Proteomics;recruit;Research;Research Infrastructure;Research Personnel;Resource Development;Resources;Risk;Role;Science;Scientific Advances and Accomplishments;Scientist;socioeconomic diversity;Staging;stem;success;successful intervention;Symptoms;Systems Biology;Targeted Research;tau Proteins;Therapeutic;therapeutic development;Thinking;tool development;Training and Education;training opportunity;transcriptome sequencing;Translational Research;translational scientist;Translations;Underrepresented Populations;Universities

PROJECT_TITLE: Indiana Alzheimer's Disease Research Center


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

PROJECT_TITLE: Administrative Core


ORG_CITY: St. Louis

ORG_NAME: ST. LOUIS VA MEDICAL CENTER

ORG_STATE: MO

PHR: The immune system defends against infections and cancer. B lymphocytes are part of the immune system. They produce antibodies to help in this fight. In addition, some antibodies help regulate normal healthy human bacteria called the microbiome. In autoimmune disease, these processes go awry. Antibodies attack the body and cause autoimmune diseases, like Rheumatoid arthritis (RA). The microbiome can also become dysregulated and may trigger autoimmune attacks. This proposal focuses on ways in which abnormal B cells and myeloid cells may also fail to regulate the microbiome, leading to worse disease outcomes. RA is one of the most common autoimmune diseases and has a disproportionate impact on women, a group of Veterans that has grown rapidly in recent decades. This proposal focuses on the effects B lymphocytes and the microbiome have on autoimmune diseases that affect our Veterans.

PI_NAMEs: KENDALL, PEGGY L (contact)

PROJECT_TERMS: adaptive immunity;Affect;Affinity;Agammaglobulinaemia tyrosine kinase;Antibiotics;Antibodies;Antigens;arm;Arthritis;Autoantibodies;Autoimmune;autoimmune arthritis;Autoimmune Diseases;autoimmune pathogenesis;Autoimmunity;autoreactivity;B-Cell Antigen Receptor;B-Lymphocytes;Bacteria;Binding;Biological Assay;Cell Physiology;Cells;Clinical;Clonality;commensal bacteria;commensal microbes;Complex;cytokine;Cytometry;Development;Disease;Disease Outcome;Environmental Risk Factor;Event;experimental study;Failure;Fc Receptor;fighting;Functional impairment;Funding;Genetic;gut bacteria;gut microbes;gut microbiome;Human;humoral immunity deficiency;Immune;Immune system;Immune Tolerance;Immunoglobulin A;Immunoglobulin G;Immunoglobulin Somatic Hypermutation;immunoregulation;In Vitro;Individual;Infection;Inflammatory;Intestines;K/BxN model;Lead;Link;Malignant Neoplasms;Mediating;Microbe;microbiome;Modeling;Molecular;monocyte;Mucosal Immunity;Mucous Membrane;Mus;Myelogenous;Myeloid Cell Activation;Myeloid Cells;novel;Organ;Organism;Outcome;Patients;peripheral blood;Peyer's Patches;Phagocytes;Play;prevent;Process;Production;protective effect;Receptor Signaling;Rheumatoid Arthritis;Role;Signal Transduction;Signaling Protein;Sorting;Structure of germinal center of lymph node;Supporting Cell;System;T-Lymphocyte;Testing;Time;Tissues;Toll-like receptors;Tyrosine Kinase Inhibitor;Veterans;Woman;Work

PROJECT_TITLE: B Lymphocytes in Autoimmune Disease


ADMINISTERING_IC: DC

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Hearing Loss;Prevention;Rehabilitation

ORG_CITY: FOREST HILLS

ORG_NAME: YORK SOUND INC

PHR: PROJECT NARRATIVE Understanding speech when other people are talking in the background is both one of the most critical and difficult issues to address for cochlear implant users. We have developed an algorithm which, in contrast to commercial algorithms, is highly successful at removing background talkers. The proposed work has been developed in conjunction with the four cochlear implant manufacturers in order to satisfy their needs for commercial readiness of the algorithm.

PI_NAMEs: LANDSBERGER, DAVID M;SOLEYMANI, ROOZBEH  (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TITLE: Commercial Readiness of a CI NR algorithm


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Kallikrein 6 (Klk6) is a specialized protein that is highly expressed in the central nervous system and implicated in diseases ranging from Alzheimer’s disease to multiple sclerosis (MS), yet its role in normal health is not well- understood. Early evidence suggests Klk6 modulates memory and learning through a novel mechanism called myelin plasticity where myelin, the insulator of electrically active neurons, is fine-tuned to enhance neuronal communication. This study will determine how Klk6 regulates myelin, and if it influences myelin plasticity, which has strong implications for myelin-based diseases such as MS as well as our fundamental understanding of learning and memory.

PI_NAMEs: WURTZ, LINCOLN I (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Acceleration;Adult;Alzheimer's Disease;Amygdaloid structure;Anabolism;Anatomy;autocrine;Behavioral;Brain;Brain region;Cell Differentiation process;Cell Maturation;Central Nervous System;Central Nervous System Diseases;Cognition Disorders;Communication;Complex;conditional knockout;conditioned fear;Cre-LoxP;Cues;Data;Demyelinating Diseases;Development;Disease;fear memory;Female;Freezing;Fright;Functional disorder;Goals;Grant;gray matter;Health;Hippocampus;Homeostasis;Hormones;improved;innovation;Kininogenase;knock-down;Knock-out;knockout animal;knockout gene;Knockout Mice;Knowledge;Label;Learning;Libraries;long term memory;LoxP-flanked allele;male;Maps;Measures;Mediating;Mediator;Memory;Mental disorders;Modeling;Molecular;Motor;Motor Cortex;motor learning;Multiple Sclerosis;Mus;Myelin;Myelin Proteins;myelination;Names;neglect;neural network;Neurobiology;Neuroglia;neuroinflammation;Neurologic;Neurology;Neurons;Neurosciences;Neurosciences Research;new therapeutic target;novel;oligodendrocyte progenitor;Oligodendroglia;paracrine;Pathology;Pathway Analysis;Pattern;Phenotype;Physiologic pulse;Post-Traumatic Stress Disorders;precursor cell;Prefrontal Cortex;preservation;Process;Production;progenitor;protein expression;Proteinase-Activated Receptors;Proteins;Proto-Oncogene Proteins c-akt;Psychiatry;Reporter;Research;response;Role;Running;Scientific Advances and Accomplishments;Series;Serine Protease;Shapes;Signal Pathway;single-cell RNA sequencing;Slice;Social Behavior;social learning;Spinal Cord;Spinal cord injury;stem cells;Testing;Therapeutic;white matter;Work;young adult

PROJECT_TITLE: Mechanisms of Kallikrein 6 in Myelin Plasticity, Motor Learning, and Fear Memory


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Physical Rehabilitation;Rehabilitation

ORG_NAME: REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB

PHR: PROJECT NARRATIVE Powered devices can more fully replace function lost due to leg amputation, but current devices are heavy and have not been studied for people designated as K2-level ambulators, who are typically prescribed passive devices but may benefit from powered devices. Our proposed project will evaluate the benefits of providing power either at the knee, ankle, or both knee and ankle, using our novel, lightweight powered knee and ankle components that are likely more suitable for K2-level ambulators. Our results will provide metabolic, biomechanical, and functional evidence to support prescription of powered components to K2-level ambulators, which may improve their independence, mobility, and quality of life, and allow clinicians to select appropriate components to optimize function, based on the individual user’s needs and preferences.

PI_NAMEs: HARGROVE, LEVI JOHN (contact)

PROGRAM_OFFICER_NAME: NURMINSKAYA, MARIA

PROJECT_TERMS: Activities of Daily Living;Affect;Algorithms;American;Amputation;Amputees;Ankle;ankle joint;ankle prosthesis;biomechanical test;Biomechanics;Categories;Classification;Clinical;clinical decision-making;clinical training;Common Data Element;Communities;cost;Data;Devices;disability;Employment;energy efficiency;Energy Metabolism;Equilibrium;Evaluation;expectation;Femur;foot;functional improvement;Gait;gait rehabilitation;Generations;Goals;improved;improved mobility;Individual;innovation;Intention;Joints;Knee;Knee joint;Knee Prosthesis;Learning;Leg;Leisure Activities;light weight;Limb Prosthesis;Limb structure;Lower Extremity;Measures;Medicare;Metabolic;Microprocessor;Mobility decline;novel;Outcome;Outcome Measure;Outcome Study;Patient Self-Report;Performance;Persons;Population;powered prosthesis;preference;primary outcome;Prosthesis;Quality of life;Ramp;Randomized;recruit;Research;secondary outcome;Self-Help Devices;Surveys;Testing;Torque;Training;Triton;United States National Institutes of Health;Walking;Weight;Work

PROJECT_TITLE: Understanding how Powered Componentry Impacts K2-Level Transfemoral Amputee Gait

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Cancer;Patient Safety

PI_NAMEs: BRUCE, JUSTINE YANG (contact)

PROJECT_TERMS: authority;Cancer Center;Cancer Control;Cancer Therapy Evaluation Program;Clinical Research;Clinical Research Protocols;Communities;Comprehensive Cancer Center;Data;Disease;Enrollment;Ensure;ethnic minority;frontier;Funding Agency;human subject protection;improved;Individual;Industry;Institution;Institutional Review Boards;Instruction;life span;Malignant Neoplasms;Mission;Monitor;NCI-Designated Cancer Center;operation;Peer Review;Performance;Population;Process;Protocols documentation;racial minority;Recommendation;Research;Resource Allocation;Review Committee;Rural Population;Safety;Source;System;Translational Research;Underrepresented Populations;United States National Institutes of Health;Woman

PROJECT_TITLE: Protocol Review and Monitoring System


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

PHR: Project Narrative Despite Hispanic Latinos having an increased risk for developing Alzheimer’s disease (AD) among all ethnic groups in the US, there is decreased or no association of the leading genetic risk factor Apolipoprotein E4 (APOE4) in AD. It is suggested that genetic variation specific to Mexican Ancestry, possibly regulatory, modifies APOE4 expression or function to protect against AD risk association. Understanding the mechanisms by which Mexican genetic ancestry modifies APOE4-mediated AD risk would identify novel therapeutic targets for APOE4 carriers and address a health disparity by studying genetic risk in an underrepresented ethnically diverse population.

PI_NAMEs: MEYER-ACOSTA, KARINA K (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: 3-Dimensional;Abeta synthesis;Address;Alleles;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;apolipoprotein E-3;apolipoprotein E-4;Biological Assay;Biological Models;Biology;Brain;Cell Death;Cell Differentiation process;cell type;Cells;Central America;Cerebrum;Cessation of life;Characteristics;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Data;differential expression;Disease;disease model;disease phenotype;disorder risk;Dorsal;Enzyme-Linked Immunosorbent Assay;ethnic diversity;Ethnic Origin;Ethnic Population;excitatory neuron;experimental study;Fellowship;Gene Expression;Genes;Genetic;genetic manipulation;Genetic Risk;genetic risk factor;Genetic study;Genetic Transcription;Genetic Variation;Genome;genome wide association study;Genotype;Geography;Growth;health disparity;Heritability;high risk;Hispanic;Hispanic ancestry;Human;human induced pluripotent stem cells;Immunohistochemistry;Impaired cognition;Impairment;In Vitro;Individual;induced pluripotent stem cell;induced pluripotent stem cell technology;inhibitory neuron;insight;Latino Population;Learning;Measures;Mediating;Methods;Mexican;Mexican Americans;Molecular;multi-ethnic;Neuroglia;Neurons;new therapeutic target;Not Hispanic or Latino;novel;Organoids;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Phenotype;Physiological;Population;Population Heterogeneity;Proliferating;protective effect;protein expression;Proteins;Risk;risk variant;Role;Scientist;skills;South American;stem;stem cell technology;Support Groups;tau-1;Testing;therapeutic target;Training;transcriptome sequencing;Variant;Western Blotting

PROJECT_TITLE: Modeling Alzheimer's Disease in Hispanic Latino populations using human cortical organoids


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences

PI_NAMEs: BROSCH, JARED R (contact)

PROJECT_TERMS: Acceleration;Affect;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Autopsy;Bioinformatics;Biological Markers;Blood;Brain;Clinical;clinical examination;Cognition;Cognitive;Cognitive aging;cohort;Collaborations;Communities;Data;data management;Data Set;data sharing;Dementia;DNA;Early Diagnosis;Early Onset Alzheimer Disease;education research;Enrollment;Environment;Familial Dementias;Family;Family member;follow-up;Fostering;Frontotemporal Dementia;Funding;Genetic;Goals;Grant;Healthcare;Image;improved;Indiana;Individual;Industry;Infrastructure;Inherited;innovation;Interdisciplinary Study;interest;International;Investigational Drugs;Late Onset Alzheimer Disease;Mission;multidisciplinary;multiple omics;Neurodegenerative Disorders;neuroimaging;neuropathology;Neuropsychology;nonalzheimer dementia;outreach;Paper;Participant;Patients;Peer Review;peripheral blood;Peripheral Blood Mononuclear Cell;Pilot Projects;Plasma;Play;pre-clinical;prodromal Alzheimer's disease;programs;recruit;Research;Research Infrastructure;Research Personnel;research study;Research Subjects;Resource Sharing;Resources;RNA;Role;Sampling;Science;Serum;Specimen;Standardization;statistics;Systems Biology;Training and Education;training opportunity;translational potential;United States National Institutes of Health;Work

PROJECT_TITLE: Clinical Core


ORG_CITY: SAINT LOUIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: SAINT LOUIS UNIVERSITY

PHR: This is a new application that builds upon a 30-year history of federal funding for predoctoral training in the pharmacological sciences at Saint Louis University. Our broadly-based multidisciplinary approach involves 30 faculty from eight departments in the Colleges of Medicine, Arts & Sciences, and Engineering at Saint Louis University. The training program includes classical concepts of pharmacokinetics, pharmacodynamics, and toxicology, as well as state-of- the-art quantitative biology, chemical biology, and drug discovery technology and approaches.

PI_NAMEs: CHAKRABORTY, ANUTOSH ;WALKER, JOHN K.;YOSTEN, GINA L.C. (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Grant;pharmacologic;Science;Training

PROJECT_TITLE: Pharmacological Sciences Training Grant


PI_NAMEs: YU, MENGGANG  (contact)

PROJECT_TERMS: anti-cancer research;Applications Grants;Area;Award;biomedical data science;Biometry;Biostatistics Shared Resource;Businesses;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Research Project;Clinical;Clinical Trials;Collaborations;Communication;Comprehensive Cancer Center;Consultations;Contracts;cost effectiveness;Data;Data Analyses;Dedications;Development;Discipline;Disease;Documentation;Education;Ensure;Environment;Faculty;faculty mentor;Fee-for-Service Plans;Foundations;Funding;Goals;graduate student;Grant;Human Resources;improved;Information Dissemination;Infrastructure;Institution;Instruction;interdisciplinary approach;Interdisciplinary Study;Knowledge;Laboratories;Leadership;Link;Malignant Neoplasms;Medical Informatics;meetings;member;Mentors;Methodology;Methods;Mission;Modeling;Monitor;NCI Center for Cancer Research;novel;operation;Outcome;Peer Review Grants;Population Sciences;Privatization;Productivity;programs;Protocols documentation;Publications;Research;Research Design;Research Methodology;Research Project Grants;research study;Safety;Sample Size;Scientist;Standardization;statistics;student mentoring;Students;Study Subject;success;technical report;theories;tool;Training;United States National Institutes of Health;Universities;Wisconsin

PROJECT_TITLE: Biostatistics Shared Resource


ADMINISTERING_IC: DK

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: BIRMINGHAM

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: The UAB DRC is the only NIDDK diabetes center located in the Deep South, at the 'Diabetes Belt' epicenter characterized by the highest rates of diabetes in the US. Through its core facilities, pilot grants, and enrichment activities, the Center has developed an effective strategy for promoting excellence in diabetes research, new discoveries, and a strong environment for training the next generation of research leaders. Thus, the UAB DRC endeavors to develop better ways to prevent and treat diabetes, and lessen the burden of patient suffering and high social costs of diabetes.

PI_NAMEs: GARVEY, W TIMOTHY (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Administrator;Alabama;Animals;Area;Atherosclerosis;Autoimmunity;base;Basic Science;bench to bedside;Biology;Blood Vessels;Cardiometabolic Disease;career;career development;Cellular biology;circadian biology;Collaborations;Communities;community based research;Community Outreach;Complications of Diabetes Mellitus;Core Facility;cost;Creativeness;Dedications;Deep South;design;Development;Diabetes Mellitus;Diabetes prevention;Direct Costs;Disease;drug discovery;Environment;Epidemiology;epigenomics;Evolution;Extramural Activities;Faculty;Fetal health;Funding;Future;Genetic;Genomics;Goals;Grant;Growth;Heart;Human;Imagination;Inflammation;innovation;Institution;interdisciplinary collaboration;Intervention;Intervention Trial;Investigation;Investments;islet;Islet Cell;Knowledge;Leadership;Learning;member;Mentorship;Metabolic Diseases;Metabolism;Mission;Mitochondria;Molecular;Morbidity - disease rate;mortality;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;Outcome;outreach;Patients;Physiology;prevent;Prevention;Process;programs;Publications;Quality of life;recruit;Research;Research Personnel;Research Project Grants;Research Training;Resource Allocation;Scientist;Signal Transduction;Sleep;social;Societies;student training;Technology;Training;Translating;translational pipeline;Translational Research;Translations;Universities;Vascular Diseases;Work

PROJECT_TITLE: UAB Diabetes Research Center


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Data Science;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PI_NAMEs: GAO, SUJUAN  (contact)

PROJECT_TERMS: Address;Alzheimer's Disease;Alzheimer's Disease Core Center;Alzheimer's disease related dementia;Bioinformatics;Biological Markers;Biometry;cell repository;Clinical;Collaborations;Consultations;daily functioning;dashboard;Data;data access;Data Analyses;Data Collection;data dashboard;data hub;data integration;data management;Data Management Resources;data repository;Data Science;Data Set;data sharing;data visualization;Database Management Systems;Databases;Disease;doctoral student;Education;Educational Activities;Educational process of instructing;electronic data;Electronic Health Record;Enrollment;Ensure;Faculty;fighting;Genetic;Grant;improved;Indiana;Individual;individual patient;Leadership;meetings;member;Mentors;Methodology;Methods;multidisciplinary;neuroimaging;neuropathology;Online Systems;operation;outreach;Paper;Patient Schedules;Patients;Postdoctoral Fellow;Program Evaluation;Quality Control;recruit;Reporting;Research;Research Activity;Research Design;Research Personnel;Research Training;Sample Size;screening;Secure;Specific qualifier value;Specimen;statistics;Summary Reports;Technology;Time;tool;Training;Work

PROJECT_TITLE: Data Management and Statistics Core


NIH_SPENDING_CATS: Genetics;Rare Diseases

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Our research program will uncover important signals regulating RNA modifiers required for mitochondrial gene expression. RNA modifiers are associated with severe mitochondrial diseases, such as mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS); however, the cause for this link remains unclear. The central goal of this grant is to reveal how dysregulated RNA modifiers can contribute to the basic molecular mechanisms driving disease-relevant mitochondrial RNA processing pathways.

PI_NAMEs: PILLON, MONICA  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Address;Automobile Driving;Biochemistry;Collaborations;Complex;cross disciplinary program;Disease;Gene Expression;Genetic Diseases;Genomics;Goals;Grant;Hybrids;innovation;Knowledge;Link;Mammals;MELAS Syndrome;Mitochondria;Mitochondrial Diseases;Mitochondrial RNA;Modification;Molecular;Mutation;Pathway interactions;Patients;Process;programs;Proteome;Pseudouridine;Research;Ribosomal RNA;Ribosomes;RNA;RNA Editing;RNA Processing;Signal Transduction;Site;Specificity;structural biology;System

PROJECT_TITLE: New Mechanisms of the Pseudouridine Synthase Module in Mitoribosome Assembly

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Biotechnology;Cancer

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: PROJECT NARRATIVE Per PAR-21-321 instructions, this component is not required.

PI_NAMEs: COON, JOSHUA J (contact)

PROJECT_TERMS: anti-cancer research;Biotechnology;cancer cell;Cancer Center;cancer therapy;Cantor;Cell Physiology;Chemistry;Collaborations;Communities;Comprehensive Cancer Center;Consult;Consultations;Core Facility;cost;Data;design;Education;Event;Experimental Designs;Faculty;Funding;Goals;Grant;Human;Infrastructure;insight;Instruction;Laboratories;Leadership;lipidomics;Lipids;Malignant Neoplasms;mass spectrometric imaging;Mass Spectrum Analysis;meetings;member;Metabolic;metabolomics;Mission;Modeling;outreach;Peer Review;Pharmacy facility;Post-Translational Protein Processing;Process;professor;programs;progression marker;Proteins;Proteomics;Publications;Research;Research Personnel;Research Project Grants;Resources;Services;Structure;success;Surveys;System;Technology;technology development;Therapeutic;Time;timeline;tumor progression;United States National Institutes of Health;Universities;Wisconsin;Work

PROJECT_TITLE: Cancer Metabolomics and Proteomics


PI_NAMEs: GHETTI, BERNARDINO FRANCESCO (contact)

PROJECT_TERMS: Affect;Alzheimer's Disease;Archives;Astrocytes;Autopsy;Biochemical;Biological;Biological Markers;Biotechnology;Brain;brain tissue;Clinical;clinical conference;Collaborations;Collection;Communication;Communities;Confocal Microscopy;Continuing Education;Cryoelectron Microscopy;Data;demented;Dementia;Development;Diagnosis;Diagnostic;diagnostic development;digital imaging;Disease;DNA analysis;early onset;Education;Electron Microscopy;Etiology;Evolution;Extracellular Protein;Family member;Formalin;Genetic;Genotype;Goals;Haplotypes;Heterogeneity;Histology;Human;Image Analysis;imaging biomarker;Immunofluorescence Immunologic;Immunohistochemistry;Indiana;Individual;Inherited;insight;Institution;interdisciplinary approach;interest;International;Label;Laboratories;laboratory facility;lectures;Lesion;Libraries;Liquid substance;Longitudinal Studies;Measures;Medical Students;Medicine;Methods;Microglia;Mission;Molecular;Molecular Conformation;Molecular Genetics;molecular marker;Morphology;Nerve Degeneration;neurodegenerative dementia;Neurodegenerative Disorders;neuroimaging;Neurons;neuropathology;next generation sequencing;novel;novel diagnostics;novel marker;Paraffin Embedding;Pathogenesis;Pathologic;Pathology;Patients;Phenotype;Physicians;precision medicine;programs;Proteins;Quality Control;recruit;Research;research and development;Research Methodology;Research Personnel;Research Project Grants;Research Support;Resources;Risk;Risk Factors;RNA;Schedule;Single Nucleotide Polymorphism;Structure;symposium;tau Proteins;Tissue Banks;Tissue Harvesting;Tissue Sample;Tissues;United States National Institutes of Health;Universities

PROJECT_TITLE: Neuropathology Core


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Depression;Genetics;Mental Health;Mental Illness;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative  There is currently no standardized way to identify a population of resilient individuals, thus animal models like chronic social defeat stress must be used to study stress resilience. By identifying the transcriptional changes that lead to stress resilience in rodents, we will shed light on genes that may potentially be protective against depression in humans. The goal of this work is to establish a reproducible pipeline that can be used to study transcriptional mechanism of stress resilience.

PI_NAMEs: GYLES, TREVONN MICHAEL (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Anhedonia;Animal Model;Animals;anti-depressive agents;Autopsy;Behavior;Behavioral;Behavioral Paradigm;behavioral phenotyping;Bioinformatics;Biological;Brain region;brain tissue;Chronic;Chronic stress;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;combinatorial;Complex;Data;depression prevention;depressive symptoms;design;Development;differential expression;disability;drug discovery;Exhibits;experience;Experimental Designs;experimental study;Exposure to;Fellowship;Future;Gene Expression;Gene Expression Profile;Gene Expression Profiling;gene network;Genes;Genetic;Genetic Transcription;genetic variant;genome wide association study;Goals;Human;Individual;insight;Investigation;Major Depressive Disorder;Mediating;Mental Depression;Mental disorders;Molecular;mouse model;Mus;Network-based;Neurobiology;Neurons;novel;Nucleus Accumbens;Outcome;overexpression;Patients;Persons;Phenotype;Physiological;Population;Predisposition;Process;protective allele;Publishing;Reproducibility;Research;Research Personnel;resilience;Rest;Risk Factors;risk variant;Rodent;social;social defeat;Standardization;Stress;stress related disorder;stress resilience;Study models;success;Syndrome;Testing;Time;Training;transcriptome sequencing;Validation;Viral;Work

PROJECT_TITLE: Gene Expression Profiling of Stress Resilient Mice within the Nucleus Accumbens


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine;Prevention

PI_NAMEs: LANG, JOSHUA MICHAEL (contact)

PROJECT_TERMS: Address;Amendment;Basic Science;biobank;Biological Assay;Biological Markers;biomarker development;Blood;Blood specimen;Cancer Biology;cell free DNA;Cells;Certification;circulating biomarkers;Circulation;Clinical;clinical care;clinical diagnostics;Clinical Oncology;Clinical Research;clinical translation;Clinical Trials;Collaborations;Comprehensive Cancer Center;Core Facility;cytokine;Data;Development;Diagnostic;Disease;drug development;Ensure;Equipment;exosome;Faculty;Funding;Gene Expression;Gene Expression Profiling;genetic analysis;Genomics;Goals;Hygiene;Immune;improved;innovation;innovative technologies;Institution;Instruction;Investigation;Journals;Laboratories;liquid biopsy;Liquid substance;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;member;minimally invasive;Molecular;Monitor;Multi-Institutional Clinical Trial;Neoplasm Circulating Cells;neoplastic cell;novel;novel marker;Outcome;patient stratification;Patients;Peer Review;pharmacodynamic biomarker;Phenotype;Plasma;predictive marker;Preparation;Procedures;Process;Prognostic Marker;programs;prospective;Proteins;Publications;Reproducibility;Research;research clinical testing;Research Infrastructure;Research Personnel;resistance mechanism;Review Committee;Sampling;Services;Strategic Planning;Structure;Technology;Testing;therapy resistant;Training;transcriptomics;Translating;Translational Research;Translations;treatment response;tumor DNA;Validation;validation studies;Wisconsin

PROJECT_TITLE: Circulating Biomarker Core


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Aurora

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE Our sense of taste is mediated by taste buds on the tongue surface, and we use this sensory system to allow us to choose what to eat and what to avoid. Taste bud cells, like skin, continually renew throughout life, making taste prone to damage from infection, cancer therapies and aging. Here we investigate how taste buds constantly regenerate to better understand how to ultimately mitigate taste dysfunction in people.

PI_NAMEs: BARLOW, LINDA A (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Ablation;Adult;adult stem cell;Affect;Aging;base;beta catenin;Bioinformatics;Body Weight decreased;Cancer Patient;cancer therapy;Cell Differentiation process;Cell Lineage;cell regeneration;cell type;Cells;Competence;Darkness;Data;Desire for food;Development;Diphtheria Toxin;Drug Targeting;Dysgeusia;Eating;Epithelium;Erinaceidae;Functional disorder;Genes;Genetic;GLI gene;Grain;Homeostasis;Housing;In Vitro;in vivo;Infection;Injury;intestinal crypt;Intestines;keratinocyte;Lateral;LGR5 gene;Life;Light;Malignant Neoplasms;Mediating;Mental Depression;Modeling;Molecular;Molecular Genetics;Multipotent Stem Cells;Mus;Natural regeneration;Oranges;Organoids;Pathway interactions;patient population;Patients;Persons;Pharmaceutical Preparations;Population;prevent;Process;Production;progenitor;Proliferating;Publishing;Quality of life;Receptor Cell;reconstitution;sensory system;Signal Transduction;single-cell RNA sequencing;skills;Skin;Social isolation;Sodium Chloride;stem;stem cell expansion;stem cell function;stem cell population;stem cell survival;stem cells;Supporting Cell;Surface;Taste Bud Cell;Taste Buds;Taste Perception;Testing;Therapeutic;Tongue;tongue papilla;transcriptomic profiling;transcriptomics;tumor;WNT Signaling Pathway

PROJECT_TITLE: Characterization of progenitor populations in adult taste epithelium


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

PI_NAMEs: WANG, SOPHIA  (contact)

PROJECT_TERMS: Address;African American;African American population;aging related;Alzheimer's Disease;Awareness;Biological Markers;Brain;brain health;care systems;Caregivers;Clinical Research;cohort;Collaborations;Collection;Communities;community advisory board;community collaboration;community organizations;Community Outreach;community partnership;COVID-19 pandemic;dashboard;Data;Databases;demented;Dementia;Development;Disease;Disparity;Dissemination and Implementation;Early Diagnosis;education resources;Effectiveness;Enrollment;ethnic minority;Event;experience;Family;Family member;Foundations;Future;Goals;Health Fairs;Health Professional;Health Services;high risk;Impaired cognition;Indiana;Internet;Investments;late life;member;mild cognitive impairment;Mission;Monitor;Nerve Degeneration;neuroimaging;Newsletter;older adult;outreach;outreach program;Participant;Patients;Persons;Play;prevent;Privatization;programs;Public Health;racial minority;Radio;recruit;Recruitment Activity;Research;Research Infrastructure;research study;retention rate;Role;rural dwellers;social media;social service provider;Strategic Planning;success;Time;Translations;Trust;Underrepresented Populations;Veterans;virtual;Work

PROJECT_TITLE: Outreach, Recruitment and Engagement Core


ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Circadian disruption (CD) is a strong risk factor for β-cell failure and diabetes. Though we and others have shown the critical function of the intrinsic molecular clock in β-cells, the molecular mechanisms involved in CD-induced metabolic and mitochondrial dysfunction in β-cells are not known. With compelling preliminary data in mouse and human β-cells that identify clock-controlled pathways involved in substrate flexibility and mitochondrial function, successful completion of the proposed experiments will help identify mechanism-based druggable pathways to prevent, mitigate, and reverse CD-induced β-cell failure and diabetes.

PI_NAMEs: YECHOOR, VIJAY K (contact)

PROGRAM_OFFICER_NAME: SILVA, CORINNE M

PROJECT_TERMS: antagonist;ARNTL gene;Attenuated;Beta Cell;blood glucose regulation;Cell Line;Cell Physiology;circadian;Circadian desynchrony;Circadian Dysregulation;circadian pacemaker;circadian regulation;Coupling;Data;Development;Diabetes Mellitus;diabetes risk;diabetic;diabetic patient;Dose;Enhancers;Ensure;environmental intervention;Epidemic;Etiology;experimental study;Failure;Fasting;Fatty acid glycerol esters;Feedback;feeding;flexibility;Food;Functional disorder;gain of function;gene therapy;General Population;Genes;Genetic;Genetic Models;Genetic Transcription;Glucose;Human;Impairment;improved;Incidence;insulin secretion;Intervention;islet;Jet Lag Syndrome;Light;loss of function;Mediating;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic Pathway;Metabolic syndrome;Metabolism;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;molecular clock;molecular modeling;Morbidity - disease rate;mortality;mouse model;Mus;Nuclear Receptors;Nutrient;overexpression;oxidation;Pathway interactions;PDH kinase;pharmacologic;Physiological;Plasma;Populations at Risk;Prediabetes syndrome;prevent;Production;Pyruvate;Regulation;Risk;Risk Factors;Secondary to;shift work;social;stable isotope;Stimulus;Structure of beta Cell of islet;Techniques;Testing;Therapeutic;Therapeutic Intervention;transcription factor;Transcriptional Regulation;translational applications;Up-Regulation

PROJECT_TITLE: Circadian disruption-induced mitochondrial dysfunction in diabetes


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Machine Learning and Artificial Intelligence;Patient Safety;Prevention;Primary Health Care;Skin Cancer

ORG_CITY: SAN DIEGO

ORG_NAME: VERISKIN, INC.

PHR: Project Narrative The lack of accurate, objective skin cancer assessment tool for non-expert clinicians leads to preventable loss of lives and costs the US healthcare system over $8B each year.  VeriSkin’s TruScore device enables a low cost, non-invasive, easy-to-use skin cancer diagnostic method that will (1) facilitate more accurate and non-subjective assessment of suspect skin lesions by both, non-expert clinicians and dermatologists, and (2) enable more accurate targeting of patients for biopsies and specialist referrals resulting in reduction in both the number of missed skin cancers (saved lives) and (2) provide overall reduction in skin cancer treatment costs.  The requested funds will be used to perform FDA pivotal clinical trial to obtain premarket approval for the TruScore device.

PI_NAMEs: CHACHISVILIS, MIRIANAS  (contact)

PROGRAM_OFFICER_NAME: EVANS, GREGORY

PROJECT_TERMS: absorption;Adoption;Assessment tool;Benign;Biopsy;Blood;Blood flow;Blood Vessels;Breakthrough device;Cancer Detection;Cancer Diagnostics;carcinogenesis;Caring;Cicatrix;Clinical;Clinical Data;Clinical Research;clinical research site;Clinical Trials;clinically relevant;cost;Coupled;Cutaneous;Dermatologist;Dermatology;design;Detection;Device Approval;Devices;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic algorithm;Diagnostic Equipment;Diagnostic Procedure;Early Diagnosis;Evaluation;Failure;falls;Funding;Goals;Grant;Health Care Costs;Healthcare;Healthcare Systems;hemodynamics;Image;improved;Institutional Review Boards;Intercellular Fluid;Lesion;Light;Machine Learning;machine learning algorithm;Malignant - descriptor;Malignant Neoplasms;Malpractice;Marketing;Measurement;Measures;mechanical pressure;Methods;Morphology;Multi-site clinical study;Neoplasms;Network-based;neural network;Non-Invasive Detection;novel;Optics;Pathologic Neovascularization;Pathway interactions;Patient-Focused Outcomes;Patients;Performance;pressure;prevent;Primary Care;primary care practice;Probability;Procedures;Production;programs;Provider;provider adoption;Research;response;Risk;Screening for Skin Cancer;Sensitivity and Specificity;Series;Skin;Skin Abnormalities;Skin Cancer;skin lesion;Specialist;Specificity;Technology;temporal measurement;Training;Treatment Cost;trial planning;tumor;Tumor Tissue;Uncertainty;vascular abnormality;Vascular resistance;Vascularization;wasting;Work;Wound Infection

PROJECT_TITLE: Pivotal Clinical Study of the TruScore Device for Non-Invasive Skin Cancer Diagnostics


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Loss of function mutations in the chromatin remodeling protein ATRX are found in 30% of pediatric high grade glioma (pHGG), yet no therapies have been employed to target ATRX loss. We recently discovered that HGG cells with isogenic ATRX loss demonstrate reduced expression of Checkpoint Kinase 1 (CHK1); and HGG cells with isogenic ATRX loss demonstrate inappropriate release of cell-cycle checkpoints after irradiation and radio- sensitization with inhibitors of the master cell-cycle regulator ATM. This proposed research plan will reveal the epigenetic mechanism of cell-cycle dysfunction in ATRX mutated-pHGG and the impact and targetability of concurrent H3F3A mutation.

PI_NAMEs: KOSCHMANN, CARL J (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: ATRX gene;Automobile Driving;Binding;Brain;Brain Stem;Cell Cycle;Cell Cycle Checkpoint;Cell Cycle Progression;Cell Cycle Regulation;Cells;CHEK1 gene;CHEK2 gene;Childhood;Childhood Glioma;chromatin remodeling;comparison control;Data;Dependence;Deposition;Development;Diffuse intrinsic pontine glioma;DNA;DNA Damage;DNA Repair;DNA replication fork;embryonic stem cell;Enhancers;Epigenetic Process;experimental study;Functional disorder;gain of function mutation;Genetic;Genetically Engineered Mouse;genomic locus;Glioma;H3 K27M mutation;Histone H3;Histones;Human;Impairment;inhibitor;irradiation;knock-down;Knowledge;loss of function mutation;Maintenance;Malignant Childhood Neoplasm;Modeling;mouse model;Mus;mutant;Mutate;Mutation;new therapeutic target;Normal Cell;novel;Outcome;overexpression;Pathway interactions;Patients;permissiveness;pharmacologic;Phase;Phenotype;Pre-Clinical Model;precursor cell;promoter;Proteins;Psychological reinforcement;Radiation therapy;Radiation Tolerance;Radiosensitization;Regulator Genes;Research;Role;Science;Site;Subgroup;Survival Rate;targeted treatment;Tissues;Transcriptional Regulation;Translating;Untranslated RNA;Variant

PROJECT_TITLE: The role of ATRX mutation in the epigenetic dysregulation of cell cycle in pediatric high-grade glioma

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: MADISON

PI_NAMEs: DEWEY, COLIN NOEL (contact)

PROJECT_TERMS: Acceleration;Adopted;Adoption;Algorithms;anti-cancer research;Applications Grants;Area;artificial neural network;Award;Bioinformatics;Biological;Biometry;Businesses;Cancer Center;Cancer Center Support Grant;Clinical;Clinical Informatics;Collaborations;Comprehensive Cancer Center;computational pipelines;Computational Science;Computing Methodologies;computing resources;cost;Data;Data Analyses;Dedications;deep learning;deep neural network;Development;Direct Costs;Discipline of obstetrics;Doctor of Philosophy;Electronic Health Record;Emerging Technologies;Ensure;Epigenetic Process;experience;Faculty;Funding;Funding Agency;Gene Expression;Genome;genome annotation;graduate student;Grant;Growth;Gynecology;Head and Neck Cancer;heterogenous data;high dimensionality;High-Throughput Nucleotide Sequencing;Image;Image Analysis;Immune signaling;Individual;Informatics;informatics shared resource;innovation;Instruction;Machine Learning;Malignant Neoplasms;Medical Informatics;member;Mentors;method development;Methodology;Mission;Modeling;Natural Language Processing;NCI Center for Cancer Research;novel;Pilot Projects;Positioning Attribute;Postdoctoral Fellow;professor;programs;Radionuclide therapy;Research;Research Design;Research Personnel;Research Project Grants;Resources;Role;Scientist;Services;single-cell RNA sequencing;skills;Standardization;System;Technology;Time;transcription regulatory network;transcriptome sequencing;United States National Institutes of Health;Universities;Wisconsin;Work

PROJECT_TITLE: Cancer Informatics Shared Resource


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PI_NAMEs: WU, YU-CHIEN  (contact)

PROJECT_TERMS: 3-Dimensional;Academia;Aging;Alzheimer's Disease;Alzheimer's disease model;Amyloid;animal imaging;arterial spin labeling;Award;Biological Markers;Brain imaging;Cataloging;causal variant;Clinical;Clinical assessments;Clinical Research;cognitive testing;Collaborations;Communities;connectome;cooperative study;Data;data management;Data Set;Degenerative Disorder;Dementia;design;Development;Diffusion;Discipline;Disease;disease mechanisms study;drug discovery;Drug Industry;Early Diagnosis;Education;education research;Eligibility Determination;Ensure;experience;Faculty;Family;Fostering;Functional Magnetic Resonance Imaging;Funding;Genetic;genetic analysis;Genetic study;Goals;Grant;Healthcare;Human;Hybrids;Image;Image Analysis;imaging biomarker;imaging genetics;imaging modality;Impaired cognition;improved;in vivo;Indiana;Individual;Industry;Inherited;International;Magnetic Resonance Imaging;Measures;metabolomics;Methodology;Methods;mild cognitive impairment;Molecular;multimodality;Mus;Nerve Degeneration;neuroimaging;neuropathology;Neuropsychology;Neurosciences Research;new therapeutic target;older adult;outreach;Participant;Pathologic;Perfusion;perfusion imaging;Phase;Pilot Projects;Positron-Emission Tomography;Postdoctoral Fellow;pre-clinical;prevent;prisma;Productivity;programs;protocol development;Protocols documentation;Quality Control;recruit;Research;Research Personnel;Resolution;Resources;Rest;Rotation;Sampling;Scanning;Schools;Scientist;Standardization;statistics;symposium;tau aggregation;tau Proteins;Techniques;Therapeutic Effect;Therapeutic Studies;tool;Tracer;Training;Translational Research;undergraduate student;Validation;Vision

PROJECT_TITLE: Neuroimaging Core


ORG_CITY: KANSAS CITY

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE: OVERALL  The University of Kansas Alzheimer's Disease Research Center (KU ADRC) promotes Alzheimer's Disease and Related Disorders (ADRD) research. Our infrastructure and investigators advance a better understanding of AD, better care of affected persons, and new treatment interventions. For the 2021-26 cycle we will use our intellectual and infrastructure assets to address critical gaps in the AD field.

PI_NAMEs: SWERDLOW, RUSSELL H. (contact)

PROJECT_TERMS: Address;Affect;aging brain;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Automobile Driving;Back;Bioenergetics;Biological Markers;Brain;Caring;Cells;Center Core Grants;Clinic;Clinical;clinical care;clinical implementation;clinical practice;Clinical Trials;Collaborations;Development;Dryness;Education;empowerment;Energy Metabolism;Functional disorder;Funding;Genes;Genetic;Goals;Grant;health care delivery;implementation science;Infrastructure;innovation;International;Intervention;Intervention Studies;Investments;Kansas;Knowledge;Life Style;Life Style Modification;lifestyle intervention;Link;metabolic abnormality assessment;Metabolism;Mitochondria;Mitochondrial Diseases;novel;Persons;pharmacologic;Play;Prevention;Prevention Research;Process;programs;protein aggregation;Proteins;proteostasis;Publications;Research;Research Personnel;Research Project Grants;Resources;Role;Science;success;Symptoms;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Universities;Work


PI_NAMEs: CHO, STEVE YOON-HO (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Anatomy;anti-cancer research;arm;Budgets;Cancer Center;Cancer Center Support Grant;Cancer Diagnostics;cancer imaging;cancer therapy;Clinical;Clinical Cancer Center;Clinical Oncology;Clinical Research;clinical trial protocol;Clinical Trials;Communication;Comprehensive Cancer Center;Dedications;Development;Disease;dosimetry;Ensure;experience;Faculty;Goals;Human Resources;human subject;Image;Image Analysis;imaging agent;imaging modality;imaging study;Imaging Techniques;Infrastructure;innovation;Instruction;instrumentation;interest;Malignant Neoplasms;Manuals;Medical Imaging;meetings;member;Methodology;Mission;Modality;molecular imaging;multidisciplinary;novel;Outcome Measure;patient oriented;PET/CT scan;Play;Positron-Emission Tomography;Production;programs;Radial;Radiation exposure;Radiology Specialty;Radiopharmaceuticals;Reporting;Research;Research Support;Resources;response;Role;Scanning;Services;standard of care;Standardization;theranostics;Time;timeline;Training;tumor;Universities;Wisconsin

PROJECT_TITLE: Clinical Research Imaging Core


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: PROJECT NARRATIVE  Auditory perceptual learning shapes many important components of aural communication, such as speech production and phoneme discrimination, and can improve the recognition of ambiguous or degraded speech in patients with hearing loss. While the auditory cortex plays a critical role in perceptual learning, the cell types and circuits involved are only beginning to be understood. The proposed experiments will address this issue by exploring the contribution of one specific cell population, layer 5 auditory corticofugal neurons, to auditory perceptual learning.

PI_NAMEs: YING, ROSE  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Ablation;Adult;Anatomy;Animal Model;Animals;Apoptosis;Area;Area Under Curve;Auditory;Auditory area;auditory discrimination;auditory pathway;Auditory Perception;auditory stimulus;Behavior;Behavioral;Calcium;cell type;Cells;Child;Clinical;Communication;Complex;Comprehension;Control Groups;Cues;design;Detection;Development;Devices;Discrimination;Electrodes;Electrophysiology (science);experimental group;experimental study;extracellular;Familiarity;Fiber;fluorophore;Geniculate body structure;hearing impairment;Human;Impairment;improved;in vivo;Individual;Inferior Colliculus;Injections;Language Development;Learning;Maintenance;Measures;Medial;Mediating;Monitor;Morphologic artifacts;Movement;Music;neural;neural circuit;Neurons;normal hearing;Pathway interactions;Patients;Perceptual learning;Performance;Photometry;Play;Population;Positioning Attribute;Presbycusis;presynaptic;prevent;Process;Production;Psychometrics;response;Role;sensor;Sensory;sensory stimulus;Shapes;Signal Transduction;skills;sound;Speech;speech recognition;Stimulus;Testing;Time;Training;vector;Viral

PROJECT_TITLE: Corticofugal contributions to auditory perceptual learning


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: WILCOCK, DONNA M (contact)

PROJECT_TERMS: Address;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;Amyloid beta-42;Amyloid beta-Protein;Animal Model;Area;Astrocytes;Basic Science;Behavioral;Biological Markers;Blood specimen;blood-based biomarker;causal variant;Clinical;clinical predictors;Cognitive;cohort;Collaborations;Collection;Computerized Medical Record;Data;Dementia;Development;Disease;Disease susceptibility;DNA;drug development;drug discovery;Education;Fostering;Generations;Genetic;Genetic Counseling;genome resource;genome wide association study;genomic data;Genomics;Genotype;Goals;Home;Image;imaging genetics;Impaired cognition;Indiana;Individual;induced pluripotent stem cell;Inherited;innovation;interest;lectures;Link;Liquid substance;medical schools;meetings;member;Mentors;Microglia;mild cognitive impairment;Mission;Molecular;Molecular Genetics;mouse model;Multimodal Imaging;neuroimaging;Neurons;neuropathology;Neurosciences Research;normal aging;novel therapeutics;Outcome;Participant;patient population;Peripheral Blood Mononuclear Cell;Plasma;Play;pre-clinical;programs;protective factors;Recording of previous events;Research;Research Institute;Research Personnel;research study;Risk Factors;RNA;Role;Sampling;Serum;specific biomarkers;Specimen;symptom treatment;tau Proteins;Testing;Therapeutic;therapeutic evaluation;translational study;Universities;Visit;Work

PROJECT_TITLE: Genetic, Biomarker and Biospecimen Core


PI_NAMEs: BUGNI, TIMOTHY S (contact)

PROJECT_TERMS: Analytical Chemistry;anti-cancer research;Antineoplastic Agents;arm;Artificial Intelligence;Biological Assay;Cancer Center Support Grant;Cancer Patient;cancer pharmacology;cancer therapy;Chemicals;Chemoprevention;Clinical Trials;Comprehensive Cancer Center;computational chemistry;computerized tools;Conduct Clinical Trials;cost effective;data acquisition;Data Analyses;Database Management Systems;design;Developmental Therapeutics Program;Docking;drug development;drug discovery;Drug Kinetics;Ensure;Equipment;experience;Experimental Designs;Faculty;Funding;Genomics;Goals;High Pressure Liquid Chromatography;high throughput screening;Individual;Industry;Informatics;Infrastructure;infrastructure development;Innovative Therapy;Instruction;Lead;lead optimization;Legal patent;Liquid substance;Mass Spectrum Analysis;Measurement;member;Methods;Mission;National Clinical Trials Network;new technology;novel;Oncogenic;Organic Synthesis;Organoids;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Pharmacology;Postdoctoral Fellow;Process;Productivity;programs;Property;Proteins;Publications;Reproducibility;Research;research and development;Research Personnel;Resources;Sampling;screening;screening services;Secure;Services;skills;Students;Synthesis Chemistry;Tissues;Training;Training Support;virtual screening

PROJECT_TITLE: Drug Development Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: BOSTON

ORG_DEPT: CHEMISTRY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: PROJECT NARRATIVE Heparin is a sulfated, anionic polysaccharide or biomaterial isolated from porcine or bovine mucosal tissues and used to control, prevent, and treat clotting disorders. Although widely used, heparin suffers from variable performance, off-target toxicity, and supply limitations. The synthesis and performance of disulfated poly-amido-saccharides as heparin mimetics are described as an innovative solution to the supply chain shortages and the clinical need for synthetic reversible anticoagulants.

PI_NAMEs: CHAIKOF, ELLIOT ;GRINSTAFF, MARK W. (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: Address;African;Animals;Anticoagulants;Asfarviridae;beta-Lactams;Biocompatible Materials;Biological;Biological Assay;Bleeding time procedure;Blood Coagulation Disorders;Carbohydrates;Cattle;Cells;Cessation of life;Chemical Structure;Chemicals;Circular Dichroism;Classical Swine Fever;Clinical;Coagulation Process;Collaborations;Complication;cytotoxicity;Data;depolymerization;Disease;Disease Management;Dose;Double Stranded DNA Virus;Drug Kinetics;efficacy study;Elements;Enoxaparin;Epidemic;Exhibits;Experimental Designs;experimental study;Family;Family suidae;fondaparinux;Gel Chromatography;Glucose;Half-Life;Hemorrhage;Hemostatic function;heparanase;Heparin;heparin-induced thrombocytopenia;Human;hydrophilicity;improved;In Vitro;in vivo;infrared spectroscopy;innovation;interest;Intravenous;intravenous administration;Lead;Left;Life;Low-Molecular-Weight Heparin;mimetics;Modernization;Molecular;Molecular Weight;monomer;Mucous Membrane;NMR Spectroscopy;novel;Operative Surgical Procedures;Patients;Performance;pharmacokinetics and pharmacodynamics;Plasma;polymerization;Polymers;Polysaccharides;polysulfated glycosaminoglycan;Population;Positioning Attribute;prevent;Protamine Sulfate;Protease Inhibitor;Prothrombin time assay;pyranose;Reaction;response;Risk;Rodent Model;Serine Protease;side effect;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Spectrum Analysis;Structure;Structure-Activity Relationship;subcutaneous;sugar;Sulfate;supply chain;Testing;Therapeutic;Thrombin Time Assay;Toxic effect;Variant;Venous Thrombosis;Vertebral column;Viral Hemorrhagic Fevers

PROJECT_TITLE: Sulfated Poly-Amido-Saccharide (sulPAS) Biomaterials as Anticoagulants

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Physical Injury - Accidents and Adverse Effects;Prevention;Psychosis;Schizophrenia;Serious Mental Illness;Social Determinants of Health;Violence Research

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The development of strategies and interventions for preventing or minimizing violent behavior in individuals with psychotic disorders has been limited, in part, by a lack of information about the effects of antipsychotic medications, and in particular clozapine, on violent acts in community settings. In this project, we will determine whether clozapine, when administered in real-world settings, decreases the risk for violent acts in individuals with schizophrenia at high risk for violence when compared to treatment with other antipsychotic medications, and investigate whether previously identified change mechanisms are operative in the effectiveness setting. Examining clozapine in this way will foster a better understanding of the effects of clozapine on violent acts in community settings and allow us to test a scalable intervention and service delivery approaches that can be broadly implemented using typically available resources, and as such has significant public health implications.

PI_NAMEs: GOFF, DONALD C. (contact)

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: Address;Aggressive behavior;Alcohol consumption;Alcohols;Antipsychotic Agents;antisocial behavior;Behavior;blind;Clinical;Clinical Research;clinical research site;Clinical Trials;clinically relevant;Clozapine;Collaborations;community partners;community setting;community violence;Data;Delusions;Development;Diagnostic;Disparate;Effectiveness;effectiveness outcome;effectiveness study;efficacy trial;Ensure;Fostering;Future;high risk;Hostility;Human Resources;improved;Impulsivity;Individual;individual patient;interest;Intervention;intervention delivery;Interview;Link;Measures;Multi-Institutional Clinical Trial;Murder;Neurobiology;New York;open label;Outcome;Outcome Measure;Outpatients;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Populations at Risk;Positron-Emission Tomography;prevent;primary outcome;Property;Protocols documentation;psychopathic personality;Psychoses;psychotic;Psychotic Disorders;Public Health;Randomized;randomized, clinical trials;Research;Research Domain Criteria;Resources;Risk;Risk Reduction;Running;Safety;Sample Size;Schizophrenia;Sedation procedure;Self-Injurious Behavior;service delivery;Site;social stigma;Spectrum Analysis;substance use;Symptoms;Syndrome;Testing;Time;treatment as usual;treatment effect;Violence;violence prevention;Vulnerable Populations;Work

PROJECT_TITLE: 2/7 Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical Trial


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Sleep Research

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

PHR: Project Narrative: Memory is critical in driving our behavior and experiences; however, disruption to the memory formation process can quickly become maladaptive and leads to pervasive memory disorders such as post- traumatic stress disorders. Here, I propose novel pathway of communication between the anterior cingulate cortex and dorsal hippocampus CA1deep neurons underlying memory formation. Results from this study will provide new mechanistic understandings of cortex-hippocampus interactions during memory processes and shed light on how dysfunction in these processes leads to pathological memory disorders.

PI_NAMEs: HALL, ARRON FRANKLIN (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Alzheimer's Disease;Anatomy;Anterior;Automobile Driving;Behavior;Brain;Cells;Characteristics;cingulate cortex;Communication;conditioned fear;Data;Dementia;Development;dimension reduction;Dorsal;Electrophysiology (science);Event;excitatory neuron;Exhibits;experience;extracellular;fear memory;Freezing;Functional disorder;Future;hippocampal pyramidal neuron;Hippocampus;Hour;Impairment;in vivo;independent component analysis;Intervention;Learning;Linear Models;long term memory;Mediator;Medical;Memory;memory acquisition;memory consolidation;Memory Disorders;memory encoding;memory process;Nature;neural;neural network;Neurons;novel;optogenetics;Pathologic;Pathway interactions;Performance;Phase;Play;Population;Post-Traumatic Stress Disorders;Process;Property;recruit;Research Personnel;response;Role;Shock;Site;Sleep;Slow-Wave Sleep;success;System;Techniques;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;Time;Training;Wakefulness

PROJECT_TITLE: Anterior Cingulate Cortex preferentially drives dorsal CA1 deep neuronal activity during sharp-wave ripples for memory consolidation


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: CHESTNUT HILL

ORG_NAME: BOSTON COLLEGE

PHR: Narrative Apicomplexan parasites have major impacts on human health e.g. Plasmodium falciparum causes malaria whereas Toxoplasma gondii and Babesia spp. cause opportunistic infections. At the heart of all apicomplexan pathogenesis lies cell division, which unfolds in seemingly diverse and exotic ways, and is one of the defining features of the Apicomplexa. The dramatic phenomenological difference from the standard mammalian cell division model is pursued here in a opportunistic survey for urgently needed new and specific drugs to treat malaria, toxoplasmosis, and emerging tick- transmitted babesiosis.

PI_NAMEs: DURAISINGH, MANOJ T;GUBBELS, MARC-JAN  (contact);ZARRINGHALAM, KOUROSH

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Apical;Apicomplexa;asexual;Atlases;Babesia;Babesiosis;Biological;Biology;causal variant;Cell Cycle;Cell Cycle Progression;Cell division;Cells;Chemicals;Chromatin;Chromosome Segregation;Communities;comparative;Computer software;Cyclin-Dependent Kinases;Cyclins;Cytoskeleton;Data;Data Set;DNA biosynthesis;epigenomics;experimental study;Family;flexibility;Gene Expression;Gene Expression Profile;gene network;gene regulatory network;Genes;Genetic;Genetic Transcription;Health;Heart;Homologous Gene;Human;inhibitor;innovation;interest;Invaded;knock-down;Life;Life Style;Malaria;Mammalian Cell;Maps;Mediating;Modeling;Mothers;network architecture;novel;nuclear division;Opportunistic Infections;Organelles;Parasites;Pathogenesis;Pathway Analysis;Pharmaceutical Preparations;phenomenological models;Plasmodium;Plasmodium falciparum;programs;query tools;Research;Resolution;Resources;Sarcocystis;single cell ATAC-seq;single cell sequencing;single-cell RNA sequencing;software development;Surveys;System;Systems Biology;tick transmission;Time;Toxoplasma gondii;Toxoplasmosis;transcription factor;transcriptome;transcriptomics;Variant;Visualization;web app;web site;Work

PROJECT_TITLE: Comparative systems biology of apicomplexan cell division

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-L(02)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: INDIANAPOLIS

PI_NAMEs: LAHIRI, DEBOMOY K (contact)

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease related dementia;Applications Grants;Area;Award;Binding;Biological Markers;brain health;career;career development;Clinical;Collaborations;Communication;Complement;Consultations;Continuing Education;Coupled;Data Science;Databases;demented;Dementia;Development;Diagnosis;Education;education research;Elements;Evaluation;experience;Faculty;Feedback;Fertilization;Fostering;Funding;Future;Genetic;Goals;Grant;Human Resources;Imaging technology;improved;Indiana;Individual;Informatics;Infrastructure;innovation;Kentucky;Knowledge;Laboratories;Leadership;Link;Measures;member;Mentors;Mission;Modeling;Molecular Biology;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging;neuropathology;Neurosciences;next generation;Notification;novel;Participant;Pathway interactions;peer;peer coaching;Peer Review;Performance;Postdoctoral Fellow;posters;prevent;programs;Publications;Recommendation;recruit;Research;research and development;Research Personnel;Research Project Summaries;Research Support;Resources;Scientist;Services;skills;Students;success;symposium;synergism;Teacher Professional Development;Time;Training;Translating;translational scientist;Underrepresented Minority;Underrepresented Populations;Universities;Update;Work

PROJECT_TITLE: Research Education Component