ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Services;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Primary Health Care;Social Determinants of Health;Telehealth

PHR: PROJECT NARRATIVE Exploring and adopting innovative health delivery approaches such as telehealth to prevent and manage cardiometabolic risks (CMR) is essential to reducing the burden of CMR diseases and associated risks (e.g., cognitive decline and dementia) among the U.S. aging population. Through this proposed research and training plan, the applicant will use a rigorous econometrics approach to evaluate the effects of state-level payment parity requiring equal reimbursement for in-person and telehealth visits on health service utilization in the U.S. health system, and to assess how telehealth affects health behavior (medication adherence) and disease-specific quality of care for middle-aged and older adults aged 45 or above. Therefore, this project contributes to NIA’s mission to prioritize life-course prevention and intervention efforts for chronic, multi-factorial, and age-related diseases.

PI_NAMEs: ZHANG, ZHANG  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Acceleration;Adopted;Adoption;Adult;Affect;Age;age related decline;age-related disease;aged;Aging;aging population;Area;Behavior monitoring;Behavioral;behavioral health;cardiometabolic risk;Caring;Chronic;Chronic Disease;Clinical;cognitive function;Complex;County;COVID-19;COVID-19 pandemic;Data;Data Set;Data Sources;Dementia;dementia risk;Diabetes Mellitus;Disease;Disease Management;disorder risk;Distance Education;doctoral student;Dyslipidemias;Early Intervention;econometrics;Economics;Emergency department visit;Emergency Situation;Ensure;Etiology;Federal Government;Fee-for-Service Plans;Fellowship;Funding;Future;Geography;Goals;Health;Health behavior;health care availability;health care service;health care service utilization;Health Care Visit;health economics;Health education;health management;Health Policy;health service use;Health Services;Health Services Accessibility;Health system;Healthcare;Healthcare Systems;healthy aging;Hypertension;Impaired cognition;implementation science;improved;Individual;innovation;Inpatients;instrument;Insurance;Insurance Carriers;interest;Internet;Intervention;late life;Least-Squares Analysis;Life Cycle Stages;Light;Measures;Medical;Medicare;medication compliance;Mentors;Methodology;middle age;Minor;Mission;Modernization;Modification;Morbidity - disease rate;mortality;National Institute of Child Health and Human Development;older adult;older patient;Older Population;Outcome;pandemic disease;parity;Patient Care;Patients;payment;Persons;Pharmaceutical Preparations;Physical Function;Policies;Population;population health;Population Study;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;prevent;Prevention;Privatization;Provider;Public Policy;Quality of Care;Quasi-experiment;Regulation;Research;Research Personnel;response;Risk;Risk Factors;screening;Services;Shock;social;Sociology;Source;State Government;Target Populations;Technology;telehealth;Telemedicine;Time;tool;Training;Training Programs;United States;Universities;uptake;Visit;Work

PROJECT_TITLE: The Impact of Telehealth on Healthcare Utilization, Health Behavior and Quality of Care for Middle-aged and Older Adults with Cardiometabolic Risk


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: BERKELEY

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: Project Narrative Characterization of human retinal ganglion cells in action will add to our understanding of the organization of visual perception and of the neural code leaving the eye. This work could inform the development of human visual prostheses. It could also be used to develop diagnostic tools to better inform the treatment of glaucoma, by detecting abnormalities in OFF retinal ganglion cell receptive fields.

PI_NAMEs: JOHNSTON, LEAH  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: absorption;Accounting;adaptive optics;Address;Affect;Area;Automobile Driving;Axon;Brain;California;cell type;Cells;Characteristics;Clinical;clinical diagnostics;clinically relevant;Code;Cone;Conscious;Data;Data Analyses;Data Collection;Degenerative Disorder;desensitization;design;Development;diagnostic tool;Early Diagnosis;Electrophysiology (science);Evaluation;experience;Eye;falls;fovea centralis;Functional Magnetic Resonance Imaging;Future;gaze;Glaucoma;habituation;Health;Human;human subject;in vivo;Individual;Knowledge;laboratory experience;Light;Link;Literature;Macaca;Maps;Measurable;Measurement;Methods;microstimulation;model building;Modeling;mosaic;neural;Neural Pathways;neuroadaptation;Neurons;novel;Ocular Prosthesis;Optic Nerve;Optics;paired stimuli;Pathway interactions;Peripheral;Photoreceptors;Physiologic pulse;Physiology;Primates;professor;Property;Protocols documentation;Psychophysics;receptive field;Reporting;Research;Research Proposals;Resolution;response;Retina;Retinal Diseases;retinal ganglion cell degeneration;Retinal Ganglion Cells;Retinal Photoreceptors;retinal prosthesis;retinal stimulation;Shapes;Signal Transduction;Stimulus;Structure;Talents;Techniques;Testing;Time;Tissues;transmission process;Universities;Vision;Visual;Visual Perception;Work

PROJECT_TITLE: Leveraging Single Cell Stimulation to Untangle Parallel Perceptual Pathways in the Human Retina

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03B-L (20)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Machine Learning and Artificial Intelligence

ORG_CITY: SALT LAKE CITY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Double-stranded RNA (dsRNA) is found in most human genes, but its role in gene expression is not well understood. Our research using the model organism C. elegans aims to reveal how dsRNA interacts with diverse proteins to shed light on diseases associated with dsRNA, such as autoimmune disorders, cancers, and neurological conditions like epilepsy and Alzheimer's. This knowledge could ultimately contribute to the development of novel therapeutic strategies to combat these illnesses.

PI_NAMEs: ANDREWS, RYAN JOHN (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Alzheimer's Disease;Antibodies;Autoimmune Diseases;Bass;Behavior;Biochemistry;Biological;Biology;C. elegans genome;Caenorhabditis elegans;Cell Nucleus;cell type;classification algorithm;combat;Complex;CRISPR/Cas technology;Cytoplasm;Data;design;Development;Disease;distinguished professor;Double-Stranded RNA;ds RNA-Binding Proteins;Embryo;Environment;Epilepsy;Essential Genes;experience;Future;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genomics;Goals;Heterochromatin;Home;Human;immune RNA;Immunoprecipitation;Innate Immune Response;innovation;insight;Introns;Knowledge;Left;Link;Liquid Chromatography;Location;Machine Learning;machine learning classification;Malignant Neoplasms;Maps;Mass Spectrum Analysis;medical schools;Mentorship;Messenger RNA;model organism;Molecular Biology;mRNA Precursor;Muscular Dystrophies;Nervous System Disorder;Neurologic;Neurons;novel therapeutic intervention;Nuclear;Outcome;Pathway interactions;Pattern;Phase;post-doctoral training;Process;protein complex;Proteins;Proteomics;real-time images;recruit;Regulation;Research;Resources;Ribonucleoproteins;RNA;Rod;Role;Scientist;sensor;single-cell RNA sequencing;Site;spatiotemporal;Structure;tandem mass spectrometry;targeted treatment;Testing;Therapeutic Intervention;Thermodynamics;tool;Training;Transcript;transcriptome sequencing;Transgenic Organisms;Universities;Utah;young adult

PROJECT_TITLE: Spatiotemporal dynamics of dsRNA-protein associations throughout C. elegans development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


ADMINISTERING_IC: EB

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSURGERY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will develop a novel sonobiopsy technique to radically advance the diagnosis of patients with brain cancer, a major public health problem in the United States. This sonobiopsy technique will enable noninvasive determinations of tumor molecular signatures without surgery. It is expected that this novel technique will potentially impact the management of a broad spectrum of brain diseases.

PI_NAMEs: CHEN, HONG  (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: 3D Print;Acoustics;Address;Adoption;Adult;Algorithms;Alzheimer's Disease;Anatomy;animal data;Automobile Driving;Biological Markers;Biopsy;Blood;Blood - brain barrier anatomy;Blood Circulation;Brain;Brain Diseases;Brain Neoplasms;Cephalic;Clinic;Clinical;clinical practice;Clinical Research;clinical translation;Clinical Trials;Coupling;design;design and construction;detector;Development;Device Designs;Devices;Diagnosis;diagnostic value;Effectiveness;Elements;Engineering;Ensure;Excision;Face;Feedback;first-in-human;Focused Ultrasound;Friends;Funding;Future;Glioblastoma;Hair;Head;Histologic;Human;improved;Individual;individual patient;innovation;lens;liquid biopsy;Location;Magnetic Resonance Imaging;Malignant neoplasm of brain;manufacture;Mediating;Medical;Microbubbles;Mineral Oil;Molecular;Molecular Diagnosis;Molecular Profiling;Molecular Target;Monitor;mouse model;multidisciplinary;National Institute of Biomedical Imaging and Bioengineering;Nervous System Disorder;neuroimaging;Neuronavigation;neurosurgery;next generation;nonhuman primate;novel;Operative Surgical Procedures;Outcome;Patients;Performance;personalized care;Phase;porcine model;Positioning Attribute;Primary Brain Neoplasms;Procedures;Public Health;Research;Risk;risk minimization;Safety;safety and feasibility;Sampling;Sonication;specific biomarkers;success;System;Techniques;technology platform;Testing;Therapeutic Agents;Tissues;Transducers;Translating;treatment response;tumor;tumor diagnosis;tumor progression;Tumor-Derived;Ultrasonic Transducer;Ultrasonography;ultrasound;United States;United States National Institutes of Health;Validation;wearable device;X-Ray Computed Tomography

PROJECT_TITLE: Focused ultrasound-enabled brain tumor liquid biopsy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-C (03)]


NIH_SPENDING_CATS: Aging;Cardiovascular;Estrogen;Heart Disease;Heart Disease - Coronary Heart Disease;Neurosciences;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: RELEVANCE TO PUBLIC HEALTH The nervous system of the heart plays a key role in the development and progression of heart failure and occurrence of dangerous heart rhythms, such as ventricular arrhythmias, that lead to sudden death. Differences exist in both occurrence and outcomes of ventricular arrhythmias in men vs. women, yet the mechanism behind these differences remain unknown. The current proposal is aimed at identifying sex-specific remodeling in the heart and its nervous system after cardiac injury and associated hormonal factors that may play a role in this remodeling, in order to provide important mechanistic insights as to the observed differences in occurrence of sudden death and progression of heart failure in males vs. females.

PI_NAMEs: RIPPLINGER, CRYSTAL MAY;VASEGHI, MARMAR  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Acceleration;Acetylcholine;afferent nerve;Age;Animals;Anti-Arrhythmia Agents;Autonomic ganglion;Autonomic nervous system;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiovascular Diseases;Catecholamines;Chronic;Clinical;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Dangerousness;Data;Development;Disease;Efferent Neurons;Electrophysiology (science);Epinephrine;Estrogens;Evaluation;Female;Fluorescence Resonance Energy Transfer;Functional disorder;Gonadal Steroid Hormones;Health;Heart;Heart Diseases;Heart failure;Heart Injuries;heart innervation;heart rhythm;hemodynamics;Heterogeneity;Histologic;Hormonal;Imaging Techniques;improved;Incidence;individualized medicine;Infarction;insight;Ischemia;ischemic cardiomyopathy;Knowledge;male;Maps;Mediating;Mediator;men;middle age;Molecular;Morbidity - disease rate;mortality;Mus;Muscle Cells;Myocardial;Myocardial Infarction;myocardial injury;Nerve;nerve supply;Nervous System;neural;Neural Pathways;Neurons;Neuropeptides;neurotransmission;neurotransmitter release;Neurotransmitters;Norepinephrine;novel;novel therapeutics;Optics;optogenetics;Outcome;Output;Ovariectomy;Oxidative Stress;Pathogenesis;Pathologic;Pathway interactions;Pattern;Peptides;Perimenopause;Peripheral;Play;Postmenopause;Public Health;Reporting;response;Risk;Role;sex;sex as a biological variable;Sex Differences;side effect;Signal Transduction;Stress cardiomyopathy;Structural defect;sudden cardiac death;Sudden Death;Syndrome;targeted treatment;Techniques;Testing;Tissues;Ventricular Arrhythmia;Woman;Women's mortality

PROJECT_TITLE: Sex differences in cardiac autonomic remodeling after myocardial infarction

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Brain Disorders;Cerebrovascular;Nanotechnology;Neurosciences;Physical Rehabilitation;Regenerative Medicine;Rehabilitation;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stroke

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE Ischemic stroke is the leading cause of disability in adults in the U.S., and there is no treatment that promotes recovery. The proposed predoctoral NRSA aims to examine innate cellular responses to a potential stroke therapeutic, a biocompatible hydrogel scaffold that establishes a unique neurovascular niche after stroke. This study will assess in vivo revascularization of the stroke infarct in mice, vascular-guided cellular migration, and axonal sprouting in the gel, infarct and peri-infarct with and without physical rehabilitation.

PI_NAMEs: RATHBUN, ELLE MAI (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Active Sites;Acute;Adult;Affect;Anatomy;angiogenesis;Area;Astrocytes;attenuation;Automobile Driving;Axon;axonal sprouting;Biocompatible Materials;Biological;Biological Testing;Biology;biomaterial compatibility;Blood - brain barrier anatomy;Blood flow;Blood Vessels;blood-brain barrier permeabilization;Brain;brain tissue;Cell Death;cell motility;cell type;Cells;cellular imaging;Clinical;clinical translation;clinically relevant;Collaborations;crosslink;Data;design;disability;drug development;Embolism;Endothelial Cells;Engineering;Environment;Extracellular Space;Forelimb;Gel;Growth;Hemorrhage;Human;hydrogel scaffold;Hydrogels;hydrophilicity;Image;Immobilization;Immunofluorescence Immunologic;improved;in vivo;Infarction;Infiltration;Inflammatory;Injectable;Injections;Ischemic Stroke;Label;Longitudinal Studies;Maps;Matrix Metalloproteinases;Measures;Metalloproteases;Methodology;Microscopic;migration;mortality;Motor Cortex;motor rehabilitation;Mus;nanoparticle;National Research Service Awards;nerve stem cell;neural repair;Neuroglia;neuronal circuitry;Neurons;neurovascular;novel;oligodendrocyte progenitor;Parents;particle;Perfusion;Pericytes;Permeability;Pharmaceutical Preparations;Physical activity;Physical Rehabilitation;Physical therapy;Polymers;Population;Porosity;porous hydrogel;post stroke;pre-doctoral;precursor cell;Production;Productivity;Recovery;Recovery of Function;rehabilitation paradigm;Rehabilitation therapy;repaired;response;revascularization;Risk Factors;Rodent;Role;scaffold;serial imaging;Signal Transduction;Stroke;stroke patient;Structure;Synapses;synaptogenesis;Testing;Therapeutic;therapeutic candidate;Thrombus;Time;tissue repair;Tissue Survival;Tissues;Training;two-photon;United States;Universities;Vascular Endothelial Growth Factors;Viral;Virus;Work;years of life lost

PROJECT_TITLE: Post-Stroke Neurovascular Function and Repair within a Porous Hydrogel

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01A-V (20)]


ADMINISTERING_IC: AI

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Complementary and Integrative Health;Digestive Diseases;Emerging Infectious Diseases;Immunization;Infectious Diseases;Microbiome;Nutrition;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: RIVERSIDE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: PROJECT NARRATIVE The pathogenic bacterium Vibrio cholerae causes cholera, a devastating diarrheal disease that affects millions of people worldwide each year. Several life-saving oral cholera vaccines (OCV) have been developed, but they show varying efficacy in different geographical regions and from individual to individual. The proposed studies will identify how differences in the composition of the native microbial community of the gut, the gut microbiome, contributes to differences in response to oral cholera vaccines, and identify candidate next- generation probiotic and prebiotic approaches targeting the gut microbiome to improve strategies for cholera prevention.

PI_NAMEs: AHERN, PHILIP PATRICK;HSIAO, ANSEL  (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: Address;Affect;Antibody Response;Area;booster vaccine;candidate identification;CD4 Positive T Lymphocytes;Cells;Cessation of life;Child;Cholera;Cholera Vaccine;Clinical Research;Communities;Data;Data Set;Development;Diarrhea;diarrheal disease;Diet;Disease;dysbiosis;Economics;Effectiveness;enteric pathogen;Etiology;Exhibits;experimental analysis;Exposure to;fecal transplantation;Gastrointestinal tract structure;Generations;geographic difference;Geographic Locations;Geography;Germ-Free;global health;Gnotobiotic;Goals;gut microbes;gut microbiome;gut microbiota;Health Priorities;Human;human pathogen;Immune;immune function;Immune response;Immune system;Immunology;Impairment;improved;Individual;Indonesia;Infection;insight;inter-individual variation;Intestines;Laboratories;Life;Link;Malnutrition;Mediating;member;Metagenomics;Microbe;microbial;microbial community;Microbiology;microbiome;microbiota;microbiota composition;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mucous Membrane;multidisciplinary;Mus;Nature;next generation;Oral;Oral Rehydration Therapy;oral vaccine;Outcome;Output;pathogenic bacteria;Patients;Peripheral;Persons;Phenotype;Population;prebiotics;Predisposition;Prevention;Probiotics;Prophylactic treatment;protective efficacy;rational design;Regulatory T-Lymphocyte;respiratory;response;Shapes;skills;social;Source;Stress;System;Testing;Therapeutic;Therapeutic Intervention;transplant model;Transplantation;Vaccination;vaccination outcome;vaccine efficacy;vaccine response;Vaccines;Variant;Vibrio cholerae;volunteer;Vulnerable Populations;Work

PROJECT_TITLE: Defining the impact of interpersonal gut microbiota variation on oral cholera vaccine responsiveness

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_DEPT: PSYCHOLOGY

PHR: Project Narrative The brain balances two strategies for decision making: goal-directed actions and habits. Dysfunction in this balance can contribute to a broad range of psychiatric disorders, including substance use disorder. This project will evaluate dopaminergic projections to the amygdala to characterize their function and necessity in learning.

PI_NAMEs: CRAWLEY, ASHLEY KAITLYN (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: addiction;Address;Amygdaloid structure;analysis pipeline;Animals;Award;Behavior;Behavior Control;Behavioral;Behavioral Paradigm;Brain;career;cell type;Cognitive;cognitive control;Cognitive deficits;Data;Decision Making;Diagnosis;Disease;Dissection;Dopamine;dopaminergic neuron;Eating;Ensure;Equilibrium;Event;Feedback;Fiber;Fire - disasters;flexibility;Functional disorder;Future;Goals;habit learning;Habits;Human;Image;Immunohistochemistry;in vivo;innovation;Investigation;Knowledge;Lateral;Learning;learning outcome;Mediating;Memory;Mental disorders;Midbrain structure;Modeling;Monitor;neural;neural circuit;neuronal circuitry;Neurosciences;Operant Conditioning;optogenetics;Outcome;Pathway interactions;Phase;Photometry;Procedures;Process;professor;prospective;Research;response;Rewards;Rodent;Role;sensor;Signal Transduction;skills;Substance Use Disorder;success;System;Taxes;Techniques;Testing;theories;tool;Training;Ventral Tegmental Area

PROJECT_TITLE: Dopamine Projections to the Amygdala in Goal-Directed and Habit Learning

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01B-M (20)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Brain Disorders;Neurosciences

ORG_CITY: CHAMPAIGN

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: The proposed work will provide a greater understanding about the inferior colliculus, which is a brain region that is critical for sound processing. We will determine if a new way of subdividing this region helps to understand its role in processing complex sounds and in compensating for damage to the inner ear.

PI_NAMEs: LLANO, DANIEL A (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustic Trauma;Acoustics;Animals;Architecture;Area;Auditory;Auditory Perceptual Disorders;auditory processing;Auditory system;auditory threshold shift;Award;Behavioral;Brain;Brain region;Brain Stem;Cell Nucleus;Cochlea;Compensation;Complex;Data;Development;Disease;Disputes;Dorsal;Dyslexia;Electrophysiology (science);Future;Hearing;hearing impairment;Heterogeneity;Image;imaging approach;indexing;Inferior Colliculus;insight;integration site;Investigation;Knowledge;Labyrinth;Lateral;Left;Maps;Measures;Medial;meter;Motor;Neurons;Noise;noise exposure;novel;Organizational Change;Pattern;Play;preference;Property;Prosencephalon;Research Project Grants;Resistance;response;Role;Sampling;Schizophrenia;Sensory;sound;Stimulus;Structure;Surface;targeted treatment;Techniques;Therapeutic Intervention;Tinnitus;two-photon;Work

PROJECT_TITLE: Novel subdivisions of the dorsal cortex of the inferior colliculus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-A (02)]


ORG_CITY: ATLANTA

ORG_DEPT: PATHOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Dynamic reorganization of the actin cytoskeleton is essential for cell migration, cell division and morphogenesis. The basic regulatory mechanism of actin dynamics will be investigated by a combination of biochemical and genetic approaches.

PI_NAMEs: ONO, SHOICHIRO  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: actin depolymerizing factor;Actins;Atomic Force Microscopy;Binding;Binding Proteins;Binding Sites;Biochemical;Biological Process;Caenorhabditis elegans;Cell division;cell motility;Cells;cofilin;Cytokinesis;Cytoskeletal Modeling;Cytoskeleton;depolymerization;Dissociation;Eukaryota;F-Actin;Filament;Fluorescence Microscopy;Gene Proteins;genetic approach;genetic regulatory protein;Human;human disease;Impairment;In Vitro;in vivo;insight;Link;Microfilaments;Microfluidics;Minus End of the Actin Filament;model organism;monomer;Morphogenesis;Muscle;Muscle Cells;Mutation;Myocardium;Nematoda;Patients;Phenotype;Physiological;Polymers;Process;Property;protein oligomer;Proteins;Regulation;Reporting;Role;Sarcomeres;Side;Skeletal Muscle;Speed;Striated Muscles;Structural Models;Structure;synergism;trafficking;Vesicle;Xenopus

PROJECT_TITLE: Actin regulation by cyclase-associated protein

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-D (02)]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Alcoholism, Alcohol Use and Health;Lung;Rare Diseases;Substance Misuse

PHR: PROJECT NARRATIVE Acute respiratory distress syndrome (ARDS) is a serious lung condition with high morbidity and mortality rates, making it a significant public health concern. The human lung maintains airspace fluid by balancing leak with fluid removal, however, claudin organization due to chronic alcohol abuse disrupts this balance by increasing leak and when paired with ARDS leads to catastrophic lung flooding. This project aims to target lung cell junctions as an approach to ameliorate lung leakage.

PI_NAMEs: IBRAHIM, YASMIN  (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Actins;Acute Respiratory Distress Syndrome;Adhesions;Affect;Affinity;Air Sacs;airway epithelium;Alcohol abuse;alcohol effect;alcohol exposure;alcohol use disorder;Alcohols;Alveolar;alveolar epithelium;Alveolus;Apical;Bacteria;Behavior;Binding;Biochemical;Biological Assay;CD47 gene;Cell surface;Cells;Chronic;Compensation;Death Rate;Diffusion;Disease;Electrical Resistance;Environment;Epithelial Cells;Epithelium;Equilibrium;Evans blue stain;Excision;experience;Extracellular Matrix;Extravasation;Family;filamin;Floods;Fluid Balance;Functional disorder;Functional impairment;Goals;Human;Image;Impairment;improved;In Vitro;in vivo;Incidence;Individual;Inflammation;inflammatory lung disease;Injury;Integrins;Intercellular Junctions;interest;Ions;Life;Ligand Binding;Ligands;Link;Liquid substance;Literature;Lung;Lung Diseases;lung injury;Measures;Mediating;Modeling;Molecular;Molecular Conformation;Monoclonal Antibodies;Morbidity - disease rate;Morphology;mouse model;Movement;new therapeutic target;Patients;Permeability;Pneumonia;Positioning Attribute;Process;Prognosis;Proteins;Public Health;Pulmonary Edema;Regulation;Role;Sepsis;Severities;Signal Pathway;Signal Transduction;Skeleton;Sodium;Structure;Talin;Techniques;Therapeutic;therapeutic target;Tight Junctions;Ventilator;Work

PROJECT_TITLE: Roles for integrins in control of lung barrier function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-K (20)]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: NEW YORK

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative The largest remaining mystery in the genomic era is assigning precise function and biophysical parameters to the vast number of regulatory sequences that govern gene expression. Connecting these features to complex cellular behavior would accelerate our ability to predict phenotypic outcomes from DNA sequence alone, potentially enabling treatment options for patients with disease causing mutations found within enhancers. By combining a high-throughput temporally-resolved screen and cutting-edge DNA loci tracking combined with transcriptional imaging all within a developmentally relevant in vitro differentiation system, we will radically redefine our understanding of how enhancers activate their target genes.

PI_NAMEs: WHITNEY, PETER H (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;adipocyte differentiation;Adipocytes;Adopted;Binding;Biological Assay;biophysical properties;Biophysics;cell behavior;Cell Nucleus;Cells;Chemicals;Chromatin;Chromatin Loop;chromatin remodeling;Chromatin Structure;Code;Collection;Color;Communication;Complex;Consensus;CRISPR interference;Data;Dependence;Development;differentiation in vitro;Disease;disease-causing mutation;DNA;DNA Binding;DNA Sequence;Elements;Enhancers;Epigenetic Process;experimental study;functional outcomes;Gene Expression;gene regulatory network;Genes;Genetic Transcription;Genomics;Goals;HDAC4 gene;Human;Human Genome;Image;Individual;Instruction;Knowledge;Label;lipid biosynthesis;Logic;Maintenance;Maps;Measures;Metabolic Diseases;Methods;Modeling;Molecular Conformation;Monitor;Movement;Mutation;novel strategies;Outcome;Output;Patients;Phenotype;Play;PPAR gamma;PPARG gene;programs;promoter;Protocols documentation;Rapid screening;recruit;Regulatory Element;Reporter;Repression;risk variant;Role;Series;Signal Pathway;Signal Transduction;small molecule;Structure;synergism;System;temporal measurement;Testing;three dimensional structure;Time;transcription factor;Transcriptional Regulation;Untranslated RNA;virtual;Work

PROJECT_TITLE: Non-coding Genomic Determinants of Adipogenesis


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Contraception/Reproduction;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Social hierarchies, which are comprised of lower-ranking subordinate individuals and higher-ranking dominant individuals, are essential for maintaining stability in humans and other species; however, the neural and molecular mechanisms that regulate a subordinate social rank and its associated behaviors are unclear. The proposed research will use state-of-the-art tools in gene sequencing and genome editing to identify the genes and cell types in the brain that govern subordinate social status and assess the roles of androgens and serotonin in regulating subordinate behavior in an African cichlid fish Astatotilapia burtoni. Given that all vertebrates have androgens, serotonin, and similar genes that regulate behavior, this work will elucidate basic biobehavioral and genetic mechanisms underlying subordination that can be further explored in other animals, including humans.

PI_NAMEs: MUNLEY, KATHLEEN  (contact)

PROJECT_TERMS: African;Aggressive behavior;Androgen Receptor;androgenic;Androgens;Animals;base;Behavior;Behavioral;Behavioral Paradigm;Binding;biobehavior;Brain;cell type;Cells;Cichlids;CRISPR/Cas technology;Cues;Data;Dominant Genetic Conditions;Exhibits;Fishes;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic signature;genome editing;Growth;Human;Hypothalamic structure;Individual;insight;Laboratories;male;mating behavior;Measures;Methods;model organism;Molecular;mutant;Nature;neural;neural circuit;neurobiological mechanism;neuromechanism;Neuromodulator;Neurophysiology - biologic function;Neurosecretory Systems;Neurotransmitters;novel;Partner in relationship;Pattern;Physiological;Process;Production;receptor;Receptor Signaling;Regulation;reproductive function;Research;response;Role;Serotonin;Serotonin Receptor 5-HT1A;Shapes;Signal Transduction;single nucleus RNA-sequencing;social;Social Behavior;Social Dominance;Social Hierarchy;Social status;steroid hormone;Steroids;System;Taxes;Technology;Testing;Testis;tool;trait;Vertebrates;Work

PROJECT_TITLE: Neural and molecular control of subordinate social status in a cichlid fish

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research;Youth Violence

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: Violence towards others and suicide are typically studied as phenomena present in discrete groups; however, self/other-directed harm co-occurs to yield a higher risk of premature death34 and represents an understudied health crisis occurring in a uniquely vulnerable and often violence-exposed group.27,28,35-37 Despite decades of research we are still unable to reliably (1) identify this group on a large scale and (2) conceptualize the function of these symptoms to guide effective and scalable treatment planning. This study directly addresses these gaps by using a multidisciplinary, mixed-methods approach to help describe possible functions of self/other-directed harm.

PI_NAMEs: CASTRO-RAMIREZ, FRANCHESCA  (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Address;Adolescent;Affect;Aggressive behavior;Algorithms;Anxiety;associated symptom;Behavior;behavior measurement;Behavioral;behavioral economics;Behavioral Model;Belief;Black race;Cessation of life;Choice Behavior;Clinical;clinical decision-making;Clinical effectiveness;Cognitive;Communities;Complex;Costs and Benefits;Crime;Decision Making;Development;Diagnosis;Diagnostic;Disruptive Behavior Disorder;Economic Models;Electronic Health Record;ethnic minority status;Event;experience;Exposure to;Feeling suicidal;follow-up;Goals;Health;health care availability;health care disparity;Health Services Accessibility;high risk;Hospitals;Imprisonment;Individual;Inpatients;Intervention;Interview;Knowledge;Life;Link;Logic;Measurable;Measures;Mental Health Services;Methods;minority children;minority communities;Minority Groups;Modeling;Motivation;multidisciplinary;Neighborhoods;offender;Outcome;Outcome Measure;Patient Self-Report;Pattern;Persons;Policies;preference;premature;psychiatric comorbidity;psychological symptom;Race;racial minority;random violence;Randomized, Controlled Trials;recruit;Reporting;Research;Risk Factors;Risk Taking;Sampling;Self Direction;Self-Injurious Behavior;Severities;Social Work;Stereotyping;Stress;success;suicidal;suicidal adolescent;suicidal behavior;Suicide;Suicide prevention;Survivors;Symptoms;Testing;Trauma;trauma symptom;traumatic event;traumatic stress;treatment effect;treatment planning;Uncertainty;Victimization;Violence;violence exposure;violence perpetration;violent crime;Visit;Vulnerable Populations;willingness;Youth

PROJECT_TITLE: Violence Exposure and Perpetration in Black and Minoritized Youth

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-H (20)]


NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

ORG_DEPT: ANESTHESIOLOGY

PHR: Project Narrative Treatment of pain remains a major unmet need. Opiates continue to be useful pharmacotherapy for treatment of moderate to chronic pain but suffer from severe side effects, leads to initiation of opioid use disorders (OUD) and has led to an epidemic in America. The development of safe, effective and well tolerated pain medications without side-effects based on allosteric targets and/or distinct G-protein signaling within the mu opioid receptor will be a major advancement in the treatment of pain as well as OUD that would greatly enhance both quality and length of life of patients both in the US and worldwide.

PI_NAMEs: MAJUMDAR, SUSRUTA  (contact)

PROGRAM_OFFICER_NAME: HILLERY, PAUL

PROJECT_TERMS: Absence of pain sensation;addiction;Adverse effects;Allosteric Site;American;Analgesics;analog;Animals;antagonist;antinociception;Arrestins;Attenuated;Behavioral;Binding;Binding Sites;Biological Assay;Brain;Charge;Chemicals;Chemistry;chronic pain;Clinical;Collaborations;comparative efficacy;conditioned place preference;Coupled;Cryoelectron Microscopy;Cyclic AMP;Data;Dependence;design;Development;Epidemic;Fentanyl;fighting;Future;G-Protein Signaling Pathway;G-Protein-Coupled Receptors;Generations;Goals;GTP-Binding Proteins;Guanidines;improved;in vivo;Individual;Indoles;insight;Laboratories;Lead;Ligand Binding;Ligands;Longevity;Maps;Metabolic;Modification;Morphinans;Morphine;mouse model;mu opioid receptors;Mus;Naloxone;Names;novel;Opioid;Opioid agonist;Opioid Analgesics;opioid epidemic;Opioid Receptor Binding;opioid use disorder;Overdose;Pain;Pain management;pain relief;Parents;Patients;Penetration;Pharmaceutical Preparations;pharmacologic;Pharmacology;Pharmacotherapy;Physical Dependence;Physiology;pre-clinical;prescription opioid;Property;Protein Family;Protein Isoforms;receptor;receptor function;recruit;Reporting;Research;Resolution;Role;screening;side effect;Signal Transduction;Signaling Protein;Site;Sodium;structural biology;Structure;Substance abuse problem;synthetic opioid;Testing;tool;Ventilatory Depression;Withdrawal

PROJECT_TITLE: Efficacy and signaling modulation by targeting the sodium site at mu opioid receptor

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-Q (02)]


NIH_SPENDING_CATS: Mental Health;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_DEPT: PSYCHIATRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Neurotransmitter:sodium symporters (NSS), the target of therapeutic and illicit drugs, share a common structural core, e.g., the LeuT fold, with secondary transporters that mediate concentrative substrate symport and/or antiport. By targeting archetypes of LeuT-fold proteins the goal of this grant proposal is to identify the binding sites and permeation pathways of substrates, ions, and drugs within the transporters and the elucidation of the conformational dynamics associated with the different modes of transport, with special emphasis on how psychoactive drugs modulate the activity of the human serotonin transporter (hSERT) at the molecular level. Building on powerful approaches established in the associated labs will allow implementing a new paradigm for illuminating drug action and providing guidelines for improved therapy design.

PI_NAMEs: MCHAOURAB, HASSANE S;QUICK, MATTHIAS  (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Acids;Affect;Amino Acids;Amphetamines;antiport;antiporter;Applications Grants;Architecture;Attention deficit hyperactivity disorder;Automobile Driving;Betaine;Binding;Binding Sites;Carnitine;Cell Physiology;Chemicals;Choline;Clinical;Cocaine;Collaborations;Computing Methodologies;Coupling;Data;Disease;drug action;Drug Modulation;Drug Prescriptions;Electron Spin Resonance Spectroscopy;Electrons;Elements;Equilibrium;Event;experimental study;Family;Fluoxetine;Functional disorder;Goals;Guidelines;Health;holistic approach;Homologous Gene;Human;Human Activities;Hydrochlorothiazide;Hypertension;Illicit Drugs;improved;interest;Ion Cotransport;Ions;Length;Ligand Binding;Maps;Measurement;Measures;Mediating;Medical;member;Membrane;Membrane Transport Proteins;Mental Depression;Methods;Modeling;Molecular;Molecular Conformation;Monitor;multidisciplinary;N-terminal;neurotransmission;Neurotransmitters;Nutrient;Pathway interactions;Pharmaceutical Preparations;Pharmacotherapy;Polyamines;Positioning Attribute;Process;programs;protein folding;protein structure prediction;Proteins;psychostimulant;Psychotropic Drugs;Regulation;Reporting;Research;restraint;Role;Serotonin;serotonin transporter;Sertraline;Site;Sodium;solute;Spectrum Analysis;Spin Labels;Structure;symporter;targeted treatment;Technology;Testing;Therapeutic;therapy design;Time;Transport Process;uptake

PROJECT_TITLE: Functional Dynamics of Neurotransmitter:Sodium Symporters (NSSs)

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project Narrative Retinitis pigmentosa causes progressive loss of vision, including night blindness and poor acuity. The proposed research is relevant to public health because understanding how flexibility in the visual system circuit engages deteriorating retinal function to accelerate the loss of vision may lead to new therapeutic interventions to preserve and/or restore vision in RP. The proposed research is relevant to the mission of the NEI/NIH to prolong and protect vision of the American people

PI_NAMEs: MCCALL, MAUREEN A;MCGEE, AARON W (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Acceleration;Adult;Affect;Age Months;Amblyopia;American;area striata;autosome;Behavioral;Blindness;Brain region;Calcium;calcium indicator;Cessation of life;Characteristics;constriction;Cytoskeleton;Darkness;Deterioration;Diagnosis;Electroretinography;excitatory neuron;Exhibits;experience;experimental study;flexibility;Frequencies;Functional disorder;Gene Modified;Genes;Histology;Human;human model;Image;Immediate-Early Genes;Impairment;Individual;Inherited;Knock-in Mouse;Knowledge;Learning;Life;Light;Longitudinal Studies;Measures;Mission;mouse model;Mus;mutant;mutant mouse model;Mutant Strains Mice;Neurons;Night Blindness;North America;novel therapeutic intervention;Output;Patients;Peripheral;Persons;Photoreceptors;Point Mutation;preservation;Property;Proteins;Public Health;receptor;recruit;Research;response;Retina;Retinal Cone;Retinal Diseases;Retinitis Pigmentosa;rho;Rhodopsin;Role;sensory cortex;sight restoration;Testing;therapeutic evaluation;United States National Institutes of Health;V1 neuron;Vertebrate Photoreceptors;Vision;Visual;Visual Acuity;Visual Cortex;Visual impairment;visual plasticity;Visual System;Water;Wild Type Mouse

PROJECT_TITLE: The role of plasticity in loss of vision caused by retinitis pigmentosa

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-Y (02)]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: MONTGOMERY

ORG_NAME: ALABAMA STATE DEPT OF PUBLIC HEALTH

ORG_STATE: AL

PHR: ALABAMA DEPARTMENT OF PUBLIC HEALTH COOPERATIVE AGREEMENT APPLICATION AND JUSTIFICATION FOR  MFRPS MAINTENANCE FUNDS PROJECT NARRATIVE The Cooperative Agreement is to provide funding for the ADPH state manufactured foods program to maintain conformance with the most current version of FDA’s Manufactured Food Regulatory Program Standards (MFRPS) national standards. It will provide adequate staffing, with funding for travel and other requirements as needed, to review and inspect each food manufacturing firm in Alabama jointly with the county Public Health Environmental staff, coordinating enforcement. By having adequate specialized staff, ADPH will be able to work toward maintaining conformance with the MFRPS National Standards and participate in the national integrated food safety system.

PI_NAMEs: WALDO, MITZI  (contact)

PROGRAM_OFFICER_NAME: ARESHENKO, NICOLA

PROJECT_TITLE: Alabama Department of Public Health Maintaining Conformance of MFRPS

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 ORA-J (10)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Eye Disease and Disorders of Vision;Mental Health;Neurosciences

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The hippocampus is traditionally considered a brain region for memory, but emerging findings suggest that it may play a role in key aspects of vision. This proposal investigates the original hypothesis that the unique ability of the hippocampus to differentiate related visual stimuli may bias the allocation of object-based and feature- based attention. If confirmed, this would impact our understanding of the brain systems that control attention, reveal candidate neural sources of attention deficits in visual and other disorders, and suggest learning protocols that may have potential for rehabilitating central visual processing through hippocampal plasticity.

PI_NAMEs: RACCAH, OMRI  (contact)

PROJECT_TERMS: Affect;Anatomy;Association Learning;Attention;attentional bias;attentional control;Attentional deficit;Behavior;Behavioral;Brain;Brain region;career;Code;Color;Complex;Cues;Dedications;Discrimination;Disease;Elements;experience;extrastriate visual cortex;Eye Movements;Face;Functional Magnetic Resonance Imaging;Goals;Hippocampus;Human;Imagery;imaging study;innovation;Institution;Knowledge;Learning;Link;Literature;Measures;member;Memory;Methodology;Methods;Nature;neural;neural patterning;Neurosciences;novel;novel strategies;Participant;Pattern;Perception;Play;Principal Investigator;Probability;Process;programs;Property;Protocols documentation;Psychophysics;Rehabilitation therapy;Research;Resolution;Retrieval;Role;Shapes;Solid;Source;statistical learning;Stimulus;System;Testing;Training;training opportunity;ventral visual stream;Vision;vision science;Visual;Visual attention;Visual Cortex;visual information;visual learning;Visual Perception;visual processing;visual search;visual stimulus;Work

PROJECT_TITLE: The Role of Hippocampal Differentiation in Visual Object-based and Feature-based Attention

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE The experiments outlined here will identify the mechanisms by which two similar rhodopsin mutations, G90D and G90V, cause visual impairment using G90D and G90V knockin mice that we have generated. This proposal will seek to provide full structural and functional photoreceptor analysis of these animals, determine the molecular mechanism by which these rhodopsin mutations cause night blindness and retinal degeneration, and develop therapeutic approaches for reversing their effects.

PI_NAMEs: KEFALOV, VLADIMIR JIVKOV (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: 11 cis Retinal;9-cis-retinal;Address;Adenine;Affect;Age;Animal Model;Animals;Aspartate;base editing;base editor;Binding;Binding Proteins;Biochemical;Blindness;Cell Line;Cells;chemical stability;chromophore;clinical phenotype;Clinical Research;covalent bond;Dark Adaptation;Darkness;Data;design;Detection;Development;Disease;effective therapy;Electrodes;Electroretinography;Equilibrium;experimental study;gene repair;genome editing;Glycine;Guide RNA;Heterozygote;Human;improved;In Vitro;in vivo;Knock-in Mouse;Light;Measurement;Measures;Molecular;Morphology;Mus;mutant;Mutant Strains Mice;Mutation;Night Blindness;Opsin;Patients;Persons;Phenotype;photolysis;Photoreceptors;Physiological;Physiology;Predisposition;prevent;prime editing;prime editor;Property;Proteins;Rana;Reporting;Research;response;Retinal Degeneration;Retinal Pigments;retinal rods;Retinaldehyde;Retinitis Pigmentosa;Rhodopsin;Rod;Side;subretinal injection;Suction;System;Testing;Therapeutic;Transfection;transgene expression;Valine;Variant;Vision;Vision Disorders;Visual impairment;Work

PROJECT_TITLE: Molecular mechanism of the visual disorders caused by G90D and G90V rhodopsin mutations

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Traditional postmortem imaging of the brain continues to be very qualitative and is limited by the slow “one-at- a-time” approach. Using imaging mass cytometry (IMC), a recently developed quantitative multiplexed approach to image > 45 markers of interest, we will define the spatial signatures of the aged and Alzheimer’s (AD) brain, with particular emphasis on deriving information on microglia function and activity, in space and over time. By also developing the bioinformatics pipelines needed to evaluate brain microenvironments, our study could translate clinically towards better diagnostic and predictive capabilities for patients with dementia.

PI_NAMEs: COHEN, TODD JONATHAN (contact);STANLEY, NATALIE M

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Acceleration;Address;Age;age related;aged;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease diagnosis;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;Antibodies;Autopsy;Bioinformatics;bioinformatics pipeline;Biological Markers;Biological Response Modifiers;Brain;brain cell;Brain Diseases;brain health;Brain imaging;Brain Pathology;brain tissue;cell type;Cellular Structures;chemokine;Clinical;Clinical Pathology;clinical predictors;Cognitive deficits;Coupled;cytokine;Cytometry;Data;Dementia;dementia risk;Detection;Development;Diagnostic;Disease;Disease Progression;drug discovery;Early Diagnosis;Event;Experimental Designs;follow-up;Foundations;Functional disorder;Future;Glean;Human;human disease;Image;Immune response;Immune System Diseases;Immunologic Factors;Immunologic Markers;Impaired cognition;In Situ;Individual;innovation;insight;interest;Isotopes;Label;Link;Machine Learning;Metals;Methods;Microglia;Modality;mouse model;multiplexed imaging;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;neurogenesis;neuroinflammation;Neurons;neuropathology;neuroprotection;neurotoxic;next generation;novel;Onset of illness;Outcome;Pathology;Patients;Pattern;Peripheral;Persons;Phenotype;potential biomarker;predict clinical outcome;predictive modeling;Proteins;resilience;response;Sampling;Senile Plaques;Signal Transduction;tau Proteins;Techniques;Technology;Therapeutic Intervention;therapeutic target;Time;Translating;translational applications;translational potential;Visualization

PROJECT_TITLE: Spatial signatures of brain health and vulnerability in aging and Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-U (81)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Pediatric;Pediatric Cardiomyopathy;Rare Diseases

ORG_CITY: Nashville

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disorder. Cardiac fibrosis is a key determinant of adverse outcomes in HCM, yet there are no therapeutics that prevent fibrosis or attenuate established fibrosis. Serotonin-2B (5-HT2B) receptor expression is significantly increased in HCM patients and has demonstrated anti-fibrotic effects in several cardiopulmonary diseases; eliminating 5-HT2B activity is a novel therapeutic approach to reduce fibrosis in HCM.

PI_NAMEs: LIVINGSTON, WILLIAM BRYAN (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Ablation;Acceleration;Address;adverse outcome;Age;Amino Acids;Anisotropy;antagonist;aortic valve disorder;Arrhythmia;Atomic Force Microscopy;Atrial Natriuretic Factor;Attenuated;attenuation;Body Weight decreased;Brain;Cardiac;Cardiac Myocytes;Cardiopulmonary;Cardiovascular system;Cell Differentiation process;cell type;Central Nervous System;Cicatrix;clinically relevant;Collaborations;Collagen;Collagen Fiber;Color;coronary fibrosis;Cyclosporine;Data;Death Rate;Deposition;Development;Disease;Echocardiography;effectiveness evaluation;Environment;Extracellular Matrix;Familial Hypertrophic Cardiomyopathy;Fellowship;Fibroblasts;Fibronectins;Fibrosis;Functional disorder;Gel;Genes;Genetic;Goals;Heart;Heart Diseases;Heart failure;Heart Hypertrophy;Heart Injuries;Histopathology;human data;Hypertrophic Cardiomyopathy;Hypertrophy;in vitro Assay;Inherited;insight;Knowledge;Left ventricular structure;MAP Kinase Gene;Measures;Mechanics;Mediating;migration;mortality;mouse model;Mus;Muscle Cells;Mutation;Myocardial;Myocardial Infarction;Myocardium;Myofibroblast;Myosin Heavy Chains;novel;novel therapeutic intervention;old mice;Osmosis;Outcome;Pathologic;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Polymerase Chain Reaction;preservation;prevent;Process;Proliferating;Pulmonary Heart Disease;Pulmonary Hypertension;Pump;receptor expression;Risk Factors;Role;segmentation Image analysis;Serotonin;Serotonin Receptor 5-HT2B;Severities;Signal Transduction;Stress;Sudden Death;Testing;Therapeutic;therapeutic evaluation;Tissues;Training;treatment duration;Treatment Efficacy;Ventricular;Ventricular Cardiac alpha-Myosin;Wild Type Mouse;Withdrawal;wound;young adult

PROJECT_TITLE: Serotonin-2B receptor in hypertrophic cardiomyopathy


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: SHP2 mutations are associated with several hematopoietic disorders, to which the underlying molecular and cellular mechanism remains elusive. Understanding how BM mesenchymal niches and BM vasculature are regulated by SHP2 and RUNX2 will greatly advance our knowledge regarding hematopoiesis regulation and it will be instrumental to the development of novel therapeutics.   References 1 Tosa, I. et al. Postnatal Runx2 deletion leads to low bone mass and adipocyte accumulation in mice bone tissues. Biochem Biophys Res Commun 516, 1229-1233 (2019). https://doi.org:10.1016/j.bbrc.2019.07.014 2 Yue, R., Zhou, B. O., Shimada, I. S., Zhao, Z. & Morrison, S. J. Leptin Receptor Promotes Adipogenesis and Reduces Osteogenesis by Regulating Mesenchymal Stromal Cells in Adult Bone Marrow. Cell Stem Cell 18, 782-796 (2016). https://doi.org:10.1016/j.stem.2016.02.015 3 Bohm, A. M. et al. Activation of Skeletal Stem and Progenitor Cells for Bone Regeneration Is Driven by PDGFRbeta Signaling. Developmental cell 51, 236-254 e212 (2019). https://doi.org:10.1016/j.devcel.2019.08.013 4 Ding, L. & Morrison, S. J. Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature 495, 231-235 (2013). https://doi.org:10.1038/nature11885 5 Ding, L., Saunders, T. L., Enikolopov, G. & Morrison, S. J. Endothelial and perivascular cells maintain haematopoietic stem cells. Nature 481, 457-462 %U http://www.ncbi.nlm.nih.gov/pubmed/22281595 (2012).  6 Mizoguchi, T. et al. Osterix marks distinct waves of primitive and definitive stromal progenitors during bone marrow development. Developmental cell 29, 340-349 (2014). https://doi.org:10.1016/j.devcel.2014.03.013 7 Liu, Y. et al. Osterix-cre labeled progenitor cells contribute to the formation and maintenance of the bone marrow stroma. PLoS One 8, e71318 (2013). https://doi.org:10.1371/journal.pone.0071318 8 Chan, C. K. et al. Endochondral ossification is required for haematopoietic stem-cell niche formation. Nature 457, 490-494 (2009). https://doi.org:10.1038/nature07547 9 Omatsu, Y. The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche. Immunity 33 (2010). https://doi.org:10.1016/j.immuni.2010.08.017 10 Morikawa, S. et al. Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow. J Exp Med 206, 2483-2496 (2009). https://doi.org:10.1084/jem.20091046 11 Greenbaum, A. et al. CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance. Nature 495, 227-230 (2013). https://doi.org:10.1038/nature11926 12 Pinho, S. et al. PDGFRalpha and CD51 mark human nestin+ sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion. J Exp Med 210, 1351-1367 (2013). https://doi.org:10.1084/jem.20122252 13 Ornitz, D. M. & Marie, P. J. Fibroblast growth factors in skeletal development. Curr Top Dev Biol 133, 195-234 (2019). https://doi.org:10.1016/bs.ctdb.2018.11.020 14 Kim, J. M. et al. The ERK MAPK Pathway Is Essential for Skeletal Development and Homeostasis. International journal of molecular sciences 20 (2019). https://doi.org:10.3390/ijms20081803 15 Yang, H., Wang, L., Shigley, C. & Yang, W. Protein tyrosine phosphatases in skeletal development and diseases. Bone Res 10, 10 (2022). https://doi.org:10.1038/s41413-021-00181-x 16 Segaliny, A. I., Tellez-Gabriel, M., Heymann, M. F. & Heymann, D. Receptor tyrosine kinases: Characterisation, mechanism of action and therapeutic interests for bone cancers. J Bone Oncol 4, 1-12 (2015). https://doi.org:10.1016/j.jbo.2015.01.001 17 Ornitz, D. M. & Marie, P. J. Fibroblast growth factor signaling in skeletal development and disease. Genes Dev 29, 1463-1486 (2015). https://doi.org:10.1101/gad.266551.115 18 Lahiry, P., Torkamani, A., Schork, N. J. & Hegele, R. A. Kinase mutations in human disease: interpreting genotype-phenotype relationships. Nature reviews. Genetics 11, 60-74 (2010). https://doi.org:10.1038/nrg2707 19 Zuo, C. et al. SHP2 regulates skeletal cell fate by modifying SOX9 expression and transcriptional activity. Bone Res 6, 12 (2018). https://doi.org:10.1038/s41413-018-0013-z 20 Dong, L. et al. Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment. Nature 539, 304-308 (2016). https://doi.org:10.1038/nature20131 21 Yang, M. et al. Osteogenic Factor Runx2 Marks a Subset of Leptin Receptor-Positive Cells that Sit Atop the Bone Marrow Stromal Cell Hierarchy. Sci Rep 7, 4928 (2017). https://doi.org:10.1038/s41598-017-05401-1 22 Zhou, B. O., Yue, R., Murphy, M. M., Peyer, J. G. & Morrison, S. J. Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow. Cell Stem Cell 15, 154-168 (2014). https://doi.org:10.1016/j.stem.2014.06.008 23 Shen, R. et al. Cyclin D1-cdk4 induce runx2 ubiquitination and degradation. J Biol Chem 281, 16347-16353 (2006). https://doi.org:10.1074/jbc.M603439200 24 Vimalraj, S., Arumugam, B., Miranda, P. J. & Selvamurugan, N. Runx2: Structure, function, and phosphorylation in osteoblast differentiation. Int J Biol Macromol 78, 202-208 (2015). https://doi.org:10.1016/j.ijbiomac.2015.04.008 25 Jonason, J. H., Xiao, G., Zhang, M., Xing, L. & Chen, D. Post-translational Regulation of Runx2 in Bone and Cartilage. Journal of dental research 88, 693-703 (2009). https://doi.org:10.1177/0022034509341629 26 Huang, H. et al. A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation. Genes Dev 26, 1587-1601 (2012). https://doi.org:10.1101/gad.192054.112 27 Batth, T. S. et al. Large-Scale Phosphoproteomics Reveals Shp-2 Phosphatase-Dependent Regulators of Pdgf Receptor Signaling. Cell Rep 22, 2784-2796 (2018). https://doi.org:10.1016/j.celrep.2018.02.038

PI_NAMEs: YANG, WENTIAN  (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Adipocytes;Adipose tissue;Adult;angiogenesis;Biological Assay;Biology;Blood Vessels;bone;bone cell;Bone Marrow;bone mass;Bone Regeneration;Bone Tissue;Cartilage;Cell Lineage;Cell Maintenance;Cells;Co-Immunoprecipitations;Cyclin D1;Data;Dental Research;Development;Disease;Endothelium;erythroid differentiation;experimental study;Fibroblast Growth Factor;Flow Cytometry;Genes;Genetic;Genetic Transcription;Genotype;Goals;Hematological Disease;Hematopoiesis;Hematopoietic;Hematopoietic Neoplasms;hematopoietic stem cell niche;Hematopoietic stem cells;Homeostasis;Human;human disease;Immunity;In Vitro;in vivo;Injury;innovation;interest;International;Journals;Knowledge;Label;leptin receptor;lipid biosynthesis;Luciferases;Lymphoid;Lymphopoiesis;Maintenance;Malignant Bone Neoplasm;MAP Kinase Gene;Megakaryocytes;Mesenchymal;Mesenchymal Differentiation;Mesenchymal Stem Cells;mesenchymal stromal cell;Molecular;Multipotent Stem Cells;Mus;Mutation;Myelogenous;Nature;nestin protein;novel;novel therapeutics;osteoblast differentiation;Osteoblasts;osteochondral tissue;Osteogenesis;osteogenic;Outcome Study;Pathway interactions;PDGFRB gene;Pericytes;Phenotype;phosphoproteomics;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physiologic Ossification;Platelet-Derived Growth Factor alpha Receptor;Platelet-Derived Growth Factor beta Receptor;Platelet-Derived Growth Factor Receptor;Population;Post-Translational Protein Processing;Post-Translational Regulation;postnatal;progenitor;promoter;prospective;protein protein interaction;Protein Tyrosine Kinase;Protein Tyrosine Phosphatase;PTPN11 gene;PubMed;Receptor Protein-Tyrosine Kinases;Receptor Signaling;Regulation;Reporter;Reporting;Reticular Cell;Role;RUNX1 gene;Science;Signal Transduction;skeletal;Skeletal Development;skeletal disorder;skeletal stem cell;Source;Specific qualifier value;src Homology Region 2 Domain;src-Family Kinases;stem;stem cell expansion;stem cell fate;stem cell niche;stem cell proliferation;stem cells;Stromal Cell-Derived Factor 1;Stromal Cells;stromal progenitor;Structure;T-Lymphocyte;Testing;Text;Therapeutic;transcription factor;Transcriptional Activation;Transplantation;Tubular formation;Tyrosine Phosphorylation;Ubiquitination;Vascular Diseases;vasculogenesis;Work

PROJECT_TITLE: SHP2's Regulation of the Bone Marrow Stroma and Hematopoietic Crosstalk

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Mycobacterial pathogens are agents of deadly infectious disease, including tuberculosis (TB). A strategy for new anti-TB drugs may include targeting K+ channel proteins, which can control key metabolic pathways in mycobacteria. In this work we solve the structure of a mycobacterial K+ channel and identify its role in controlling energy metabolism, contributing to the ultimate goal of developing improved treatments to fight TB.

PI_NAMEs: ROTHBERG, BRAD S. (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Acetates;Affect;Affinity;Annual Reports;Antibiotic Therapy;Antitubercular Agents;ATP Synthesis Pathway;Binding;Carbon;Cessation of life;Communicable Diseases;Consumption;Cryoelectron Microscopy;Data;Dependence;Development;Energy Metabolism;experimental study;fighting;gene product;Gene Targeting;Genes;Genus Mycobacterium;Glucose;Goals;Health;Homeostasis;improved;Infection;inhibitor;Insertional Mutagenesis;insight;Ion Channel;Ionophores;Lead;Ligand Binding Domain;Ligands;Measurement;Measures;Mediating;Membrane;Membrane Potentials;Metabolic;Metabolic Pathway;model organism;Modeling;Molecular;Molecular Target;Multi-Drug Resistance;multidisciplinary;Multidrug-Resistant Tuberculosis;Multiple drug resistant Mycobacteria Tuberculosis;mutant;mycobacterial;Mycobacterium Infections;Mycobacterium smegmatis;Mycobacterium tuberculosis;Nigericin;novel therapeutics;Nucleotides;Orthologous Gene;Oxidative Phosphorylation;particle;pathogen;Pathway interactions;Physiological;Physiology;Potassium Channel;Production;Prokaryotic Cells;Proteins;Proton-Motive Force;Regulation;Resistance;resistant strain;Role;Source;Structure;Testing;Treatment Protocols;Tuberculosis;tuberculosis drugs;tuberculosis treatment;virulence gene;Work;World Health

PROJECT_TITLE: Ion channel regulation of ATP homeostasis in mycobacteria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-W (02)]


NIH_SPENDING_CATS: Genetics

ORG_DEPT: BIOLOGY

PHR: PROJECT NARRATIVE Ectopic centromere formation on chromosomes is associated with developmental disorders and genome instability in cancer. The goal of these proposed studies is to determine how DNA structure plays a role in centromere formation at specific loci that lack conserved DNA sequence motifs to facilitate chromosome segregation. Characterizing the mechanisms of centromere localization will contribute to our understanding of how ectopic centromeres form and how they impact human health.

PI_NAMEs: GUTEMA, LYDIA HABTAMU (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Address;Affect;Aneuploidy;Artificial Human Chromosomes;Auxins;Binding;Binding Proteins;Binding Sites;Cell Cycle;Cell division;Cell Physiology;Cells;Centromere;centromere autoantigen 80K;centromere protein A;Chromatin;Chromosomal Rearrangement;Chromosome Segregation;Chromosomes;Conserved Sequence;Cruciform DNA;Data;Deposition;Development;developmental disease;Disease;DNA;DNA Binding;DNA Library;DNA Sequence;DNA sequencing;DNA Structure;DNA-Binding Proteins;Docking;Elements;epigenetic marker;Eukaryota;Exhibits;experimental study;gene therapy;Generations;genetic element;genetic information;Genome;Genomic Instability;Genomics;Goals;Health;Histone H3;Histones;Human;human tissue;improved;insight;Kinetochores;knock-down;Knowledge;Libraries;Location;Malignant Neoplasms;Maps;Meiosis;Methods;Microtubules;Mitotic spindle;Molecular;Molecular Chaperones;nuclease;Nucleosomes;Nucleotides;overexpression;Patients;Pattern;Plasmids;Positioning Attribute;protein complex;Proteins;Research;Resolution;Role;S phase;Single-Stranded DNA;Sister Chromatid;Site;Specific qualifier value;Structure;Therapeutic Uses;tissue culture;Variant;Work

PROJECT_TITLE: Investigating the role of DNA structure in centromere specification

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Genetics;Hematology;Infectious Diseases;Lung;Rare Diseases;Regenerative Medicine;Sepsis;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

PHR: Project Narrative Sepsis-induced acute lung injury (ALI) and acute respiratory distress syndrome remains an intractable disease with a mortality rate as high as 40%. ALI/ARDS bears the hallmark of inflammatory infiltration and protein-rich edema fluid due to severe disruption of lung vascular endothelial barrier. The central objective of the proposed studies is to delineate the cellular mechanisms of endothelial regeneration and vascular repair, and thereby provide novel therapeutic strategy targeting the intrinsic regenerative and reparative mechanisms for resolution of inflammatory lung injury to prevent and treat ALI/ARDS.

PI_NAMEs: ZHAO, YOU-YANG  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: Accounting;activated protein C receptor;Acute;acute hypoxemic respiratory failure;Acute Lung Injury;Acute Respiratory Distress Syndrome;Adult;Animal Model;APLN gene;Bilateral;Blood Vessels;Bromodeoxyuridine;cecal ligation puncture;Cell Cycle Progression;Cell Proliferation;Cells;Complex;Data;Death Rate;Diphtheria Toxin;diphtheria toxin receptor;Disease;Edema;effective therapy;Endothelial Cells;endothelial regeneration;endothelial stem cell;Endothelium;FOXM1 gene;Genes;Genetic;Genetic Induction;Heart failure;Impairment;Infiltration;Inflammatory;Inflammatory Infiltrate;Injury;Label;Left;Lipopolysaccharides;Liquid substance;Lung;lung injury;lung microvascular endothelial cells;Mediating;Microvascular Permeability;Modeling;Molecular;Mus;Names;nanoparticle;Natural regeneration;novel;novel therapeutic intervention;Pathologic;Patients;Phase;plasmid DNA;Play;polymicrobial sepsis;prevent;Prevention;Proliferating;promoter;Proteins;pulmonary artery endothelial cell;Pulmonary Edema;Pulmonary Inflammation;pulmonary vascular cells;Recovery;regenerative;repaired;Reporter;Resolution;Role;Sepsis;sepsis induced acute lung injury;sepsis induced ARDS;single-cell RNA sequencing;Specific qualifier value;stem cell exhaustion;stem cell expansion;stem cell genes;stem cell proliferation;stem cells;Survival Rate;Syndrome;System;Time;Vascular Endothelium;vascular injury;Vascular Permeabilities

PROJECT_TITLE: Novel intrinsic endothelial stem cells responsible for lung endothelial regeneration and vascular repair in ARDS

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-E (03)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE Hispanic/Latino populations carry a disproportionate burden of poor cardiometabolic health outcomes, with higher rates of obesity, diabetes, and hypercholesterolemia than non-Hispanic White populations, but limited research has investigated how immigration status as a social and economic stressor contributes to disparities in cardiometabolic health and epigenetic aging across the life course among this population. This proposed research project will evaluate differences in cardiovascular disease risk factor profiles by immigration status and will estimate the associations between immigration status, accelerated epigenetic aging, and cardiometabolic health over the life course among Hispanic/Latino adults and adolescents in the United States. We anticipate the impact of this work to significantly advance our understanding of racial/ethnic disparities in cardiometabolic health and aging among Hispanic/Latino populations and to ultimately inform future cardiovascular public health interventions tailored to this group.

PI_NAMEs: AQUA, JASMINE KO (contact)

PROGRAM_OFFICER_NAME: PURKISER, KEVIN

PROJECT_TERMS: 16 year old;accelerated epigenetic aging;access restrictions;Adolescent;Adult;Age;age acceleration;Aging;Biological Assay;Blood specimen;California;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;career development;Child;Clinic Visits;cohort;Cohort Studies;Country;Data;Data Set;Deterioration;Diabetes Mellitus;Disadvantaged;Disease;Disparity;DNA Methylation;Economics;Education;Epidemiologic Methods;epigenetic aging;Epigenetic Process;ethnic disparity;ethnic minority population;Face;Fellowship;Fostering;Fright;Future;Goals;Health;health care availability;health data;health difference;Health Insurance;Health Promotion;Health Surveys;Healthcare;Heterogeneity;Hispanic;Hispanic Community Health Study/Study of Latinos;Home;Household;hypercholesterolemia;Hypertension;Immigrant;Immigration;income insurance;Insurance Coverage;Interview;Latino;Latino Population;Legal Status;Life Cycle Stages;Limited English Proficiency;Lipids;low socioeconomic status;Measures;Mediator;Not Hispanic or Latino;Obesity;Outcome;Parents;Participant;Personal Satisfaction;Policies;Population;Prevalence;programs;Psychosocial Stress;public health intervention;racial disparity;racial minority;Records;Research;Research Personnel;Research Project Grants;Risk Factors;safety net;Services;Shapes;social;social stressor;Socioeconomic Status;socioeconomics;Stress;stressor;Surveys;Time;Training;United States;Work;Youth

PROJECT_TITLE: Cardiometabolic Health and Epigenetic Aging Across the Life Course Among Hispanic/Latino Immigrant Groups in the United States

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Infectious Diseases;Lung;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

PHR: Project Narrative While vascular leak is a deadly complication of malaria, the mechanism underlying its development is poorly understood. The goal of this proposed study is to identify how platelet degranulation promotes vascular leak by driving endothelial glycocalyx breakdown and CD8 T cell activation/recruitment to the lung during severe malaria. This work is relevant to the NIH mission to develop fundamental knowledge that reduces human disease burden by defining a mechanistic pathway that could be targeted by novel adjunct therapies to disrupt the development of vascular leak in malaria.

PI_NAMEs: REED, JENNA SUSAN (contact)

PROGRAM_OFFICER_NAME: PHILP, DEBORAH

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Aftercare;Alpha Granule;Automobile Driving;Binding;Blood Platelets;Blood Vessels;Brain;burden of illness;CD44 Antigens;CD44 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;cell type;Cells;Cerebral Malaria;Clinic;Colitis;Complication;Cytoplasmic Granules;cytotoxicity;Data;Death Rate;Development;disease model;Down-Regulation;Endothelial Cells;Endothelium;Enzymes;Exhibits;Functional disorder;Glycocalyx;Glycosaminoglycans;Goals;Human;human disease;Hyaluronan;Hyaluronidase;immunoregulation;In Vitro;Infection;Inflammation;Inflammatory;insight;Intestines;Kinetics;Knowledge;Literature;Lung;Lytic;Malaria;Mediating;Mission;Modeling;Molecular;molecular sieving;mouse model;Mus;novel;Organ;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Persons;Plasma;Plasmodium;Plasmodium berghei;platelet function;Proliferating;Proteins;Proteoglycan;Publishing;recruit;Role;severe COVID-19;Severity of illness;Study Subject;T cell response;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapeutic target;Time;trafficking;United States National Institutes of Health;Vascular Diseases;Wild Type Mouse;Work

PROJECT_TITLE: Defining the role of platelet-mediated glycocalyx breakdown in driving pathogenic CD8 activity during severe malaria.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10C-D (20)]


PHR: Project Narrative Autophagy dysfunction is broadly implicated in promoting diseases ranging from neurodegeneration to aging to cancer. The fundamental autophagy protein ATG3 plays an understudied role in regulating mitochondria and endosomes, and dysregulation of these organelles are also linked to neurologic diseases. Here, I explore the cell biological consequences of a mutation to ATG3 that drives neurological disease, as well as the greater cellular consequences of these non-canonical ATG3 activities.

PI_NAMEs: GUINN, EMILY DELGADO (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TITLE: Disease consequences and regulation of autophagy-independent ATG3 activity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: PORTLAND

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative The importance of developing novel antimalarials for use in the prevention and treatment of malaria is highlighted by the emerging resistance to frontline therapeutics. Further development of historically active 4-aminoquinoline analogs has immense therapeutic potential and clinical relevance. Successful completion of this proposal will result in the advancement of a novel 4-aminoquinoline scaffold with multi-drug resistant antiplasmodial activity and an increased understanding of its molecular antiplasmodial mechanisms.

PI_NAMEs: HANDFORD, MASON JAMES (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: 4-aminoquinoline;Address;Affinity;Africa;Alkynes;analog;Anti-malarials;Area;Binding;Binding Proteins;Biological Assay;Biology;career;Cell Culture Techniques;Cells;Cessation of life;Chemicals;Clinical;clinical development;clinically relevant;combat;Combined Modality Therapy;crosslink;cytotoxicity;Data;design;Development;Diazomethane;Disease;Dose;drug development;Drug Kinetics;Drug usage;drug-sensitive;Exhibits;experimental study;Flow Cytometry;Generations;Goals;Growth;Heme;hemozoin;In Vitro;in vitro activity;in vivo;Incubated;Individual;Infection;insight;Institution;Investigation;Knowledge;Laboratories;Liver Microsomes;Malaria;Measures;Medicine;member;Metabolic;Methodology;Modeling;Molecular;Multi-Drug Resistance;Mus;nanomolar;next generation;novel;novel therapeutics;Parasites;Permeability;Persons;Pharmaceutical Chemistry;Photoaffinity Labels;Plasmodium;Plasmodium falciparum;Positioning Attribute;Preparation;Prevention;Process;Proliferating;Property;Proteins;Proteomics;Reporting;Research;Research Personnel;Resistance;Resistance development;resistant Plasmodium falciparum;resistant strain;resistome;Sampling;scaffold;Series;skills;small molecule;Southeastern Asia;Spectrum Analysis;Structure;Structure-Activity Relationship;tandem mass spectrometry;Techniques;Testing;Therapeutic;Training;ultraviolet irradiation;Work

PROJECT_TITLE: The development of novel 4-aminoquinolines as therapeutics against multi-drug resistant Plasmodium falciparum

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Neurosciences;Pediatric;Prevention

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: This study aims to identify the developmental mechanisms and windows when a frontal circuit projecting to thalamus, which is responsible for social processing, are sensitive to modulation by aberrant social experience or genetic risk of neurodevelopmental disorders. Such information will point toward therapeutic targets that allow amelioration of social deficits.

PI_NAMEs: MORISHITA, HIROFUMI  (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;Affect;Alternative Therapies;Animals;autism spectrum disorder;Behavior;Behavioral;Benzodiazepines;Brain region;Data;Development;Disease;disorder risk;early adolescence;early childhood;Electrophysiology (science);experience;Female;Fiber;Funding;Genes;Genetic;Genetic Risk;genetic risk factor;Housing;Image;Impairment;in vivo;Intervention;Life;Link;male;Measures;Medial;Mental disorders;Mus;Neurodevelopmental Disorder;Neurons;optogenetics;Partner in relationship;patch clamp;Pathway interactions;pharmacologic;Photometry;Prefrontal Cortex;prevent;Prevention;reward circuitry;Signal Transduction;social;Social Behavior;Social Controls;social deficits;Social Interaction;Social isolation;Social Responsibility;Structure of paraventricular nucleus of thalamus;Techniques;Testing;Thalamic structure;therapeutic target;TNFRSF5 gene;transcriptome

PROJECT_TITLE: Maturation of frontal cortico-thalamic circuitry in control of social behavior

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: Columbus

ORG_DEPT: CHEMISTRY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE Bacteria have evolved diverse immune systems, and studying these systems will allow us to better understand the evolution of immune systems and provide novel tools for biomedical research and disease treatment. The proposed work employs state-of-the-art cryo-EM methods, biochemical assays, and cellular assays to characterize a novel bacteria immune system. Our study has identified an inflammasome-like system in bacteria, which may be reprogrammable into a disease diagnosis and treatment tool.

PI_NAMEs: RISH, ANTHONY DEAN (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Affect;Antigen-Antibody Complex;arms race;ATP phosphohydrolase;ATPase Domain;Bacteria;Bacteriophages;Biochemical;Bioinformatics;Biological Assay;Biomedical Research;Cellular Assay;Clustered Regularly Interspaced Short Palindromic Repeats;combat;Complex;Cryoelectron Microscopy;Data Set;Development;Disease;disease diagnosis;DNA Restriction-Modification Enzymes;Evolution;Genetic Engineering;Genome;genome editing;Genomic DNA;Goals;Immune;Immune signaling;Immune system;Immunity;Immunologic Surveillance;In Vitro;in vivo;Infection;Inflammasome;insight;Lead;Mammals;Mass Spectrum Analysis;Mediating;Methods;Molecular;Molecular Cloning;Molecular Genetics;Mutagenesis;mutant;Mutate;novel;nuclease;Organism;particle;pathogen;Proteins;reconstitution;recruit;Resolution;response;restriction enzyme;sensor;Sequence Analysis;Shapes;Signal Transduction;stoichiometry;structural biology;Structure;System;Techniques;Testing;tool;Viral;Virus;Work

PROJECT_TITLE: Structure and function of a novel bacterial immune system

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04-S (20)]


ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative: Capillary malformation, one of the common vascular malformations, is comprised of enlarged and destabilized capillaries. CM is caused by a somatic mutation in the gene GNAQ; the mutation changes the arginine (R) at amino acid position 183 to glutamine (Q), which is enriched in endothelial cells found in CM specimens. The proposed study seeks to understand the R183Q point mutation in the endothelial cells and how it affects interaction with surrounding mural cells in the CM using both in vitro and in vivo experiments.

PI_NAMEs: NASIM, SANA  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Affect;Alleles;Amino Acids;Angiopoietin-2;Arginine;Basic Science;Blood capillaries;Blood Vessels;Boston;Brain;brain endothelial cell;calponin;Capillary Endothelial Cell;Cell Communication;Cell secretion;Cell Separation;Cells;cellular transduction;Characteristics;Clinical;Communication;CSF3 gene;CSPG4 gene;Cutaneous;cytokine;Data;Deformity;Desmin;Endothelial Cells;Endothelium;Environment;Event;Exhibits;experimental study;Eye;Fellowship;Foundations;Gene Expression;Genes;Glaucoma;Glutamine;GNAQ gene;Goals;GTP-Binding Proteins;hemodynamics;Histologic;Homeostasis;Human;Immunohistochemistry;In Vitro;in vivo;in vivo Model;Infant;Inflammatory;inflammatory marker;inflammatory milieu;innovation;insight;Intercellular Junctions;Interleukin-1 beta;Knock-in;Label;Lead;lentivirally transduced;Lesion;live cell imaging;Macrophage;malformation;Mentors;Messenger RNA;Morphology;mouse model;Mus;mutant;Mutation;Neurocutaneous Syndromes;Normal tissue morphology;novel therapeutics;paracrine;Patients;Pediatric Hospitals;Pericytes;Point Mutation;Port-Wine Stain;Positioning Attribute;Proteins;recruit;response;Seizures;shear stress;Signal Transduction;skills;Skin;Smooth Muscle Myocytes;Somatic Mutation;Specimen;Stroke;Sturge-Weber Syndrome;symptom treatment;Tamoxifen;Testing;Tissues;Training;transcriptome sequencing;vascular bed;Work

PROJECT_TITLE: Endothelial and mural cell interaction in capillary malformation


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Pediatric;Rare Diseases

PHR: Project Narrative Epilepsy is a common, life-altering condition, as one in ten people will experience at least one seizure in their lifetime. Completion of the proposed research will advance our understanding of the neural circuit mechanisms underlying seizure susceptibility in a mouse model of Angelman syndrome, a severe neurodevelopmental disorder in which refractory epilepsy is common. The information gained could inspire the rational design of new anti-epileptics for individuals with Angelman syndrome, and possibly other neurodevelopmental disorders.

PI_NAMEs: RINGELBERG, NICHOLAS W (contact)

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: Acute;Address;Affect;Angelman Syndrome;anti-epileptic agents;Automobile Driving;Behavior;Brain;Brain region;career;Cells;Child health care;childhood epilepsy;Clinical;Clinical Trials;comorbidity;confocal imaging;Confocal Microscopy;dentate gyrus;Development;Disease;drug development;efficacy evaluation;Electrophysiology (science);Epilepsy;Epileptogenesis;Etiology;experience;experimental study;Flurothyl;Genes;granule cell;Hippocampus;Histological Techniques;Histopathology;Image Analysis;improved;Individual;insight;Intellectual functioning disability;Intractable Epilepsy;Knowledge;Laboratories;Life;loss of function;microscopic imaging;Microscopy;motor deficit;motor impairment;mouse model;Mus;neural circuit;Neurodevelopmental Disorder;Neurologic;Neurons;neuropathology;novel;Outcome;Parahippocampal Gyrus;Parvalbumins;Pathologic;Pathology;Patients;Persons;Phenotype;Physicians;Play;Predisposition;prevent;Process;Property;Prosencephalon;protein degradation;rational design;Recurrence;Research;resilience;Role;Scientist;Seizures;severe intellectual disability;Sleep disturbances;Slice;Somatostatin;Speech;Symptoms;Testing;Therapeutic;Training;UBE3A gene;ubiquitin-protein ligase;Vasoactive Intestinal Peptide;Wild Type Mouse;Work

PROJECT_TITLE: Neural Circuit Mechanisms of Seizure Susceptibility in a Mouse Model of Angelman Syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01A-V (20)]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Lung;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: PROJECT NARRATIVE  Heart disease is the leading cause of death in the United States and about 875,000 Americans die from heart disease each year, of which 50-60% deaths are caused by coronary artery disease which can further develop into heart failure and scarring. We discovered a lung stem cell-derived exosome product and its cargo microRNAs that play an essential role in cardiac repair. In this grant proposal we will study the safety, efficacy, and mechanism of exosome inhalation therapy to treat ischemic heart diseases in both small and large animal models.

PI_NAMEs: CHENG, KE  (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: Acute Lung Injury;Acute myocardial infarction;adult stem cell;Aftercare;American;Anatomy;angiogenesis;Animal Model;Animals;Anterior;Applications Grants;Arteries;Balloon Angioplasty;bench to bedside;Blood flow;Blood-Air Barrier;Cardiac;Cardiac Myocytes;cardiac repair;Cardiovascular system;Cause of Death;Cell Survival;Cells;cellular targeting;Cicatrix;Clinical;clinical translation;Clinical Trials;clinically relevant;Coronary Arteriosclerosis;Coronary Vessels;COVID-19/ARDS;Data;Development;Dose;Echocardiography;efficacy outcomes;exosome;extracellular vesicles;Family suidae;Fibrosis;fibrotic lung disease;first-in-human;Future;Goals;Gravitation;Half-Life;Harvest;Heart;Heart Diseases;Heart failure;heart function;Heart Injuries;Heart Transplantation;Histology;Homing;Hospital Costs;Human;Immune;immunogenicity;improved;in vivo;Infarction;Inhalation;Inhalation Therapy;Injury;insight;Ischemia;Left;Life;liver function;loss of function;Lung;Lung Diseases;Lung Transplantation;Mediating;MicroRNAs;Modality;Molecular;Molecular Target;Monitor;mouse model;Mus;Myocardial Infarction;Myocardial Ischemia;Nebulizer;neovascularization;novel therapeutics;Organ;paracrine;Pathway interactions;Patients;Peptides;Play;porcine model;preclinical study;Pulmonary Circulation;Pulmonary veins;Recovery;regeneration potential;regenerative;Regenerative Medicine;Regenerative pathway;Renal function;research clinical testing;Rodent;Rodent Model;Role;Route;Safety;safety study;single cell sequencing;Source;spheroids;stem cell exosomes;stem cell therapy;stem cells;Surface;systemic inflammatory response;Testing;Therapeutic;Therapeutic Effect;therapeutic miRNA;therapy outcome;Toxic effect;transcriptome sequencing;Transgenic Mice;Translations;Transplantation;Treatment Efficacy;United States;Vascular Endothelial Cell;vesicular release

PROJECT_TITLE: Inhalable stem cell exosome therapy for cardiac injury

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Disparities and At-Risk Populations;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Infectious Diseases;Neurodegenerative;Neurosciences;Prevention;Women's Health Research

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Narrative The significant impact of olfactory disorders on safety, health and quality of life makes rapid and efficient diagnosis of anosmia and related disorders paramount. However, to effectively differentiate pathophysiological changes in olfactory function from fluctuations within a normal range, it is imperative to understand how a given individual's ability to smell can vary from day to day or across months or years. The intensive longitudinal assessments proposed here will provide an essential resource for physicians, researchers and the public to better understand how olfactory function varies across time and under different physiological conditions.

PI_NAMEs: HAYES, JOHN EDWARD;MUNGER, STEVEN D (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: 2019-nCoV;Acute;Adult;Affect;Age;age related decline;Aging;Alcohols;American;Anosmia;Biological Markers;Blood Pressure;Categories;Cerebrospinal Fluid;circadian;Circadian Rhythms;Clinical;Clinical assessments;cognitive load;cohort;Communities;comorbidity;Data;data de-identification;Data Set;demographics;Detection;Diagnosis;Diet Habits;Differential Diagnosis;Disease;Early Diagnosis;Etiology;experience;Failure;Florida;Food;Functional disorder;Gases;Glycosylated hemoglobin A;Health;health care availability;hormonal contraception;Hour;Human;Hypertension;hyposmia;Incidence;Individual;Injury;Laboratories;Learning;longitudinal analysis;Measurement;Measures;Menstrual cycle;Menstruation;Mental Depression;Neurodegenerative Disorders;normal aging;Normal Range;novel;Occupations;Odors;Olfaction Disorders;olfactory disorder;olfactory threshold;Oral;Oral Contraceptives;Parkinson Disease;Pathologic;Pennsylvania;Performance;Persons;Physicians;Physiological;Physiological Processes;pleasure;Pollen;Pregnancy;pregnant;prepregnancy;prospective;Quality of life;racial diversity;RADx Radical;Recording of previous events;recruit;Research;Research Personnel;research study;Resources;respiratory virus;rhinosinusitis;Safety;secondary analysis;Self Administration;sex;Sex Differences;Skull Base Neoplasms;Smell Perception;smell test;Smoking;standard measure;Testing;Time;tool;treatment strategy;United States National Institutes of Health;Upper Respiratory Infections;Variant;Viral Respiratory Tract Infection;Virus Diseases;Woman

PROJECT_TITLE: Intensive longitudinal assessment of human olfaction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-S (02)]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE While histone proteins are critical for packaging DNA and regulating gene expression within the cell nucleus, small changes that occur due to missense mutations in genes encoding these histones can convert them into disease-causing variants. The proposed investigations use two complementary approaches, combining rapid discovery in budding yeast with extension of these findings into human cells. These studies allow us to use disease-causing histone variants to unravel cellular pathways and functional connections fundamental to maintaining proper gene expression and protecting genome integrity.

PI_NAMEs: JONES, CELINA YVONNE (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Acetylation;Affect;Antineoplastic Agents;Automobile Driving;Biological Assay;Biological Models;Biological Process;Caffeine;cancer type;Catalytic Domain;cell growth;Cell model;Cell Nucleus;Cells;Chromatin;Collaborations;Comet Assay;Compensation;Complex;Defect;Disease;disease-causing mutation;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA Packaging;DNA Repair;Double Strand Break Repair;drug sensitivity;drug-sensitive;Engineering;Environment;Epigenetic Process;Epithelial Cells;Evolution;experimental study;Fellowship;Future;Gene Abnormality;Gene Expression;Genes;Genetic Transcription;Genome;genome integrity;genome-wide;Genomic DNA;Genotype;Goals;Growth;Head and Neck Squamous Cell Carcinoma;histone acetyltransferase;Histone H2A;Histone H3;Histone H4;Histones;HTATIP gene;Human;Human Cell Line;human disease;Impairment;improved;Individual;insight;Investigation;Lysine;Malignant Neoplasms;malignant neurologic neoplasms;Mediating;Methionine;Methylation;Missense Mutation;Molecular;mRNA Differential Displays;mutant;Mutation;N-terminal;Nervous System Disorder;Neurologic;novel;Nucleosomes;Oncogenic;oncohistone;overexpression;Pathway interactions;Pharmaceutical Preparations;Play;Post-Translational Protein Processing;prevent;Process;Proliferating;Property;protein H(3);Proteins;recruit;repaired;Repression;Role;Saccharomyces cerevisiae;Saccharomycetales;Site;System;Tail;Testing;Tissues;Training;transcriptome;transcriptome sequencing;Transferase;Translating;Variant;Work;Yeast Model System;Yeasts

PROJECT_TITLE: Leveraging a budding yeast model to characterize the functional consequences of mutations in histone genes that are implicated in human disease


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Infertility;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE The overarching goal for this project is to understand the events governing the earliest stages of mammalian embryo development; how the specialized cells that will comprise the embryo and its extra-embryonic support tissues arise. We will use the mouse as an experimentally tractable animal model system to generate foundational knowledge for extending our understanding of early embryo development to other mammalian species, provide knowledge on the origin of birth defects, and the in vitro stem cell populations than can be derived from early mammalian embryos which are increasingly used to generate embryo-like models (also referred to as synthetic embryos), and to generate cells with distinct identities having therapeutic potential.

PI_NAMEs: HADJANTONAKIS, ANNA-KATERINA  (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Animal Model;ATAC-seq;Automobile Driving;Biological Models;Biosensor;blastocyst;Cell Communication;Cell Differentiation process;cell fate specification;cell growth;Cell Lineage;Cell Polarity;cell type;Cells;Cellular biology;Cellular Structures;Chromatin;Computational Biology;Computer Analysis;Congenital Abnormality;Coupled;data modeling;Defect;Detection;Development;Developmental Biology;Disease Progression;early pregnancy loss;Embryo;embryo culture;Embryonic Development;Endoderm;Ensure;Epiblast;Event;experimental study;Extracellular Matrix;failure Implantation;Family;Fibroblast Growth Factor;Foundations;Funding;Gene Expression;Gene Expression Profiling;Gene Proteins;Generations;Genetic;Genetically Engineered Mouse;Genomic approach;Genomics;Glean;Goals;Growth Factor;Image;implantation;improved;In Vitro;in vivo;Individual;Inner Cell Mass;insight;Knowledge;Ligands;Light;light microscopy;mathematical model;Measures;Mesoderm;Methods;microscopic imaging;Modeling;Molecular;Morphogenesis;mouse development;mouse model;Mus;mutant;optogenetics;Organ;Organism;Pathway interactions;pharmacologic;Population;Positioning Attribute;preimplantation;Process;programs;protein transport;public health relevance;Reporter;Reproducibility;Resolution;RNA;Role;segregation;self organization;Series;Signal Pathway;Signal Transduction;single cell genomics;Sister;Sorting;spatiotemporal;Specific qualifier value;stem cell model;stem cell population;stem cells;Structure;synergism;System;Systems Biology;targeted treatment;Therapeutic;Therapeutic Intervention;three dimensional structure;Time;Tissues;transcription factor;Work;Yolk Sac

PROJECT_TITLE: Decoding cell states and tissue morphogenesis in the early mammalian embryo

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Neurosciences;Substance Misuse

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE This project will uncover the neuronal pathways through which chronic stress promotes premature habit formation, which will aid in understanding how chronic stress can lead to pathological habits.

PI_NAMEs: WASSUM, KATE M (contact)

PROGRAM_OFFICER_NAME: MCCLURE-BEGLEY, TRISTAN DAVID

PROJECT_TERMS: Address;ADORA2A gene;Affect;Amygdaloid structure;Anxiety;Attenuated;autism spectrum disorder;Basic Science;Behavior;Behavior assessment;Behavior Control;Behavioral;Brain;Calcium;cell type;Chronic;Chronic stress;Cognitive;comparative;conditioning;Corpus striatum structure;Coupled;Data;Decision Making;Disease;Dissection;Equilibrium;Evaluation;Exposure to;Fiber;flexibility;Foundations;genetic manipulation;Goals;habit learning;Habits;health disparity;Image;innovation;Knowledge;Learning;learning outcome;learning strategy;Mediating;Mental Depression;Mental disorders;Mental Health;Modeling;Monitor;Motivation;Neurobehavioral Manifestations;neuronal circuitry;Neurons;novel;Nutritional;Obesity;Obsessive-Compulsive Disorder;Operant Conditioning;Optics;optogenetics;Outcome;Pathologic;Pathway interactions;Photometry;Positioning Attribute;premature;prevent;prospective;recruit;Regulation;Resolution;Rewards;Schizophrenia;Stress;Substance Use Disorder;success;System;Testing;theories;Time;tool;Work

PROJECT_TITLE: Do opposing amygdala-striatal pathways enable chronic stress to promote habit formation?

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-M (02)]