NIH_SPENDING_CATS: Autoimmune Disease;Celiac Disease;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Microbiome;Nutrition;Precision Medicine

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE This proposal, will generate large integrated omics data sets, tools, and resources (including an integrated clinical research data management and informatics platform) to produce and test hypotheses on mechanisms underlying tissue destruction and healing in celiac disease. It will have a significant positive impact on human health, because it will provide a knowledge basis and resources to develop approaches for individualized patient care, and promote development of new therapeutic strategies for patients with celiac disease. Thus, this work will directly support the NIDDK mission of developing fundamental knowledge that will help reduce the burden of human disease, and improve the health of patients with digestive disease.

PI_NAMEs: BARREIRO, LUIS BRUNO;ISMAGILOV, RUSTEM F;JABRI, BANA  (contact);MURRAY, JOSEPH A

PROJECT_TERMS: Activities of Daily Living;Address;Adult;Affect;Autoimmune;biobank;Biochemical;Biological;Bone Diseases;Celiac Disease;cell type;Cells;Cellular biology;Chemistry;Child;Childhood;Cholesterol;Clinical;clinical care;clinical heterogeneity;clinical phenotype;Clinical Research;cohort;Communities;Complex;complex data;Consumption;Data;Data Analyses;data management;Data Set;Defect;Development;Diet;dietary;Digestive System Disorders;Disease;Duodenum;Epithelial Cells;Epithelium;Exclusion;Family member;follow-up;gene expression variation;Genetic;Gluten;Gluten-free diet;Guide prevention;healing;Health;Heterogeneity;HLA-DQ2;HLA-DQ8 antigen;Human;human disease;Immune;Immune system;Immunity;Immunologics;Immunology;improved;Individual;Individual Differences;Inflammatory;Informatics;Information Resources;Institution;Interferon Type II;International;Intervention;intestinal epithelium;Intestinal Mucosa;Intestines;Investigation;Iron;Knowledge;knowledge base;Link;Lipids;Lymphoma;Malignant Neoplasms;Mediating;Medical;Metabolic;metabolic phenotype;metabolomics;Metadata;Metagenomics;microbial;microbiome;microbiota;Mission;Molecular;Monitor;mucosal microbiota;Mucous Membrane;Multiomic Data;multiple omics;National Institute of Diabetes and Digestive and Kidney Diseases;non-invasive monitor;novel therapeutic intervention;novel therapeutics;Nutrient;Organoids;Pathogenesis;Patient Care;Patients;pediatric patients;personalized approach;personalized care;Population;precision medicine;precision medicine clinical trials;predictive modeling;Predisposition;Preventive;Process;Publications;Research;Resources;Role;Sampling;Science;Severities;Small intestine mucous membrane;Small Intestines;Symptom Burden;T-Lymphocyte;Testing;Tissue Model;Tissues;tool;treatment choice;user-friendly;Villous Atrophy;Vitamins;web platform;Work

PROJECT_TITLE: Tissue destruction and healing in Celiac Disease


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LA JOLLA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: CRISPR-based genome editing technologies offer great promise for correcting genetic defects in humans, however, the potential application of this technology to gene therapy has been limited by low in vivo gene correction efficiencies. My group has pioneered high efficiency germline-based CRISPR-based gene-drive and allelic-drive systems that copy cassettes or favored allelic variants in the germline using the homologous chromosome as a DNA repair template. In this proposal, we extend this system to somatic cells analyzing the mechanism for unexpectedly efficient copying of gene cassettes and allelic variants in somatic cells of fruit flies, and human cells (albeit at lower frequencies than in flies), providing a novel system with the potential to transform gene therapy strategies wherein functional sequences on the homolog chromosome are used as a repair template to correct defective alleles.

PI_NAMEs: BIER, ETHAN  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Adult;Affect;Agriculture;Alleles;Bacteria;base editing;Biology;Cell Cycle;Cell Line;Cells;Chromosome Mapping;Chromosome Pairing;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR gene drive;Culicidae;Cystic Fibrosis;Cystic Fibrosis Transmembrane Conductance Regulator;design;Development;disease model;disease-causing mutation;DNA;DNA cassette;DNA Repair;Drosophila genus;Ectopic Expression;Elements;Endonuclease I;Event;expectation;experimental study;fly;Frequencies;G2 Phase;gastrointestinal epithelium;Gene Conversion;gene correction;gene drive system;gene therapy;Genes;Genetic;genetic element;genetic variant;Genome;genome editing;genome integrity;genomic locus;Genomics;Germ Lines;Grant;Guide RNA;Homologous Gene;Human;Human Cell Line;improved;in vivo;Induced Mutation;Insect Control;insect disease vector;Insecta;insight;Mammalian Cell;Mammals;Mediating;Medicine;Meiosis;Mitotic;Modeling;mutant;Mutation;next generation;Nonhomologous DNA End Joining;notch protein;novel;novel strategies;nuclease;Organism;Outcome;Pathway interactions;Phenotype;Pigmentation physiologic function;Population;portability;postmitotic;precise genome editing;precursor cell;Process;repair model;repair strategy;repaired;Reporter;resistance allele;S phase;Sequence Homologs;Site;Somatic Cell;stem cells;System;Technology;Testing;tool;transgene expression;transmission process;Visualization;Yeasts

PROJECT_TITLE: Analysis of homolog-based CRISPR editing in somatic cells

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: HS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE. Every year, approximately 6,800 and 37,000 Black women in the United States die from lung cancer and cardiovascular diseases, respectively. Lung cancer screening with low-dose computed tomography is an evidence-based approach to reduce lung cancer mortality and can be extended to the early detection of cardiovascular diseases. However, most Black women at high risk for lung cancer are currently ineligible for lung cancer screening. The overarching goal of this research is to conduct a single-arm pilot study of U.S. Black women with a history of smoking who may not meet current eligibility criteria to examine the feasibility, acceptability, and performance of LDCT screening for lung cancer detection among this population. In addition, we will validate a deep learning image analysis pipeline for cardiovascular disease detection among this population.

PI_NAMEs: PALMER, JULIE R;YANG, CHI-FU  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, WILLIAM

PROJECT_TITLE: Evaluating the Feasibility of Lung Cancer Screening in High-Risk Black Women


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Infectious Diseases;Microbiome;Networking and Information Technology R&D (NITRD);Urologic Diseases

ORG_CITY: DURHAM

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE The goal of this research is to develop new statistical models, methods, algorithms, and software for more effective analysis of microbiome sequencing data collected under a variety of experimental and survey designs. These new statistical tools will not only lead to better prediction of the health outcomes in modern microbiome studies, but also help decipher the roles of microbiome in various diseases and biomedical processes, such as in cancer and urinary tract infections. They will help advance toward the ultimate goal of personalized interventions on the human microbiota of patients to lead to improved health.

PI_NAMEs: MA, LI  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Acute Disease;Aging;Algorithms;bacterial community;Big Data;Cancer Patient;Characteristics;Chronic Disease;Communities;Complex;Computer software;Data;Data Set;data sharing;design;Development;Disease;Effectiveness;Equilibrium;Experimental Designs;flexibility;General Population;Goals;Health;Hematopoietic Stem Cell Transplantation;Heterogeneity;high dimensionality;Human body;human microbiota;Immune response;improved;Inflammatory Bowel Diseases;Intervention;Lead;Learning;Link;Longitudinal Studies;Malignant Neoplasms;Mental Depression;Methodology;Methods;Microbe;microbial;microbial community;microbiome;microbiome analysis;microbiome composition;microbiome research;microbiome sequencing;microbiota;Modeling;Modernization;Non-Insulin-Dependent Diabetes Mellitus;Obesity;open source;Outcome;Patients;personalized intervention;Phylogenetic Analysis;Play;Process;Research;Role;Sampling;software development;Statistical Data Interpretation;Statistical Models;Structure;Surveys;Testing;Time;tool;Urinary tract infection;user-friendly;Variant;Woman

PROJECT_TITLE: Statistical modeling of cross-sample variation and learning of latent structures in microbiome sequencing data

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Aging;Clinical Research;HIV/AIDS;Infectious Diseases;Osteoporosis;Pediatric;Prevention;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative Michael Yin, MD MS is an infectious disease specialist with training in epidemiology, whose primary research and clinical interest over the last 15 years has focused on non-infectious complications of HIV and antiretroviral therapy, especially in regards to bone health. This K24 Midcareer Investigator Award will provide additional training and protected time to mentor trainees to develop patient-oriented research in the field of HIV comorbidities and complications.

PI_NAMEs: YIN, MICHAEL T (contact)

PROGRAM_OFFICER_NAME: MAHON III, ROBERT N

PROJECT_TERMS: Adolescence;Advisory Committees;aging population;AIDS clinical trial group;Anti-Retroviral Agents;antiretroviral therapy;Award;biobank;Biological Markers;Biopsy;Biopsy Specimen;bone;bone cell;bone health;bone imaging;bone loss;bone mass;bone metabolism;bone strength;Bone structure;Brazil;career;Child;Clinical;Clinical Trials;Cohort Studies;Collaborations;Communicable Diseases;comorbidity;Competence;Data;Data Analyses;Databases;design;dimensional analysis;DNA Methylation;Education;Epidemiology;epigenome;Evaluation;experience;Fatty acid glycerol esters;Fracture;fracture risk;Future;Gene Expression;Genes;Goals;high dimensionality;HIV;HIV Infections;Hormones;Image;Immunologic Markers;Impairment;In Vitro;Inflammation;inhibitor;insight;Integrase;Interdisciplinary Study;interest;Intervention;Investigation;investigator training;Knowledge;LCN2 gene;Life;life span;lipid metabolism;Mentors;Mentorship;Messenger RNA;Methylation;Midcareer Investigator Award in Patient-Oriented Research;multidimensional data;multidisciplinary;Musculoskeletal;Needs Assessment;next generation;novel;novel marker;older men;older women;Osteoblasts;Osteocalcin;Osteogenesis;osteogenic;Osteoporosis;Outcome;Pathogenicity;Pathway interactions;patient oriented research;Perimenopause;Perinatal;perinatal HIV;personalized approach;Persons;Physiologic calcification;Play;Prevention;Process;programs;Protease Inhibitor;Regimen;Research;Research Personnel;Resources;risk mitigation;Role;Safety;Serum;skeletal;Specialist;Specimen;Structure;Time;Tissues;Training;transcriptomics;translational study;Universities;Woman;Women's Interagency HIV Study;Women's study;Work;Yin;young adult

PROJECT_TITLE: Mentoring Research in Non-infectious Complications of HIV

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Health Services;Palliative Care

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE ED GOAL is a 6-minute motivational interview conducted in the emergency department (ED), which engages seriously ill, yet clinically stable, older adults to address advance care planning (ACP) with their outpatient clinician(s) and avoids a time-consuming, sensitive conversation in the time-pressured ED environment. My NIA GEMSSTAR R03 project established that ED GOAL may increase patients’ engagement in ACP yet identified opportunities for refinement, including improving efficacy by involving caregivers of patients with cognitive impairment, adding care coordination components (hand-off document, etc.) to the outpatient clinicians, and broadening reach by adapting its use by specially-trained nurses. This study will allow me to refine ED GOAL to maximize its potential efficacy and scalability, and to determine the preliminary efficacy of ED GOAL on increasing ACP engagement (by self-report and in the electronic medical record) one month after leaving the ED in a pilot randomized controlled trial (N=120, 60 in each group).

PI_NAMEs: OUCHI, KEI  (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Acceleration;acceptability and feasibility;Accident and Emergency department;acute care;Address;Advance Care Planning;advanced directive;Aging;Alzheimer's Disease;Alzheimer's disease patient;Behavior Therapy;care coordination;career development;Caregivers;caregiving;Caring;Clinical;Clinical Trials;Communication;Computerized Medical Record;Consultations;Consumption;Decision Making;Dementia;design;Development;Disease;Doctor of Philosophy;Documentation;efficacy testing;Emergency Department Physician;Emergency department visit;Emergency Medicine;Emergency Nursing;end of life care;Ensure;Environment;Exclusion;Family;Feedback;Focus Groups;Foundations;Friends;Funding;Future;Geriatric Nursing;Geriatrics;Goals;Gunshot wound;Health Services Research;Healthcare;Home;Hospitals;Impaired cognition;implementation science;improved;Inpatients;International;Intervention;Interview;K-Series Research Career Programs;Knowledge;Life;Life Extension;Measures;Medical;medical schools;Mentors;Methods;Modeling;motivational enhancement therapy;Nurses;Nursing Faculty;nursing intervention;Nursing Research;older adult;Outpatients;Palliative Medicine;Participant;patient engagement;Patient Self-Report;Patient-Centered Care;Patients;Physicians;pilot test;Pragmatic clinical trial;pragmatic trial;Preparation;pressure;primary outcome;Proxy;Quality of Care;Quality of life;randomized controlled design;Randomized, Controlled Trials;Research;Research Personnel;Research Training;Resource-limited setting;Risk;Scientist;secondary outcome;sexual assault;Signal Transduction;Site;skills;Specific qualifier value;standard of care;Structure;Surveys;systematic review;Targeted Research;Testing;Time;Training;Training Programs;treatment arm;treatment as usual;Venous;Woman

PROJECT_TITLE: ED GOAL: An Advance Care Planning Intervention for Seriously Ill Older Adults in the Emergency Department


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Hearing Loss;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BALTIMORE

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Determining whether treating hearing loss can help reduce the risk of Alzheimer's disease and related dementias (ADRD) is important given that hearing loss is highly prevalent in older adults and hearing aids are widely available, underutilized, and not associated with any medical risk. This proposed follow-up study to the Aging & Cognitive Health Evaluation in Elders (ACHIEVE) randomized trial will determine the long-term, 6-year effects of hearing loss treatment on cognitive, dementia, and brain outcomes among 977 older adults with hearing loss.

PI_NAMEs: CORESH, JOSEF ;LIN, FRANK R (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Adult;Affect;Age;Aging;Alzheimer's disease related dementia;Brain;brain health;brain magnetic resonance imaging;Brain region;brain volume;Clinical;clinical care;Cognitive;cognitive load;cohort;Complement;Control Groups;County;Data;Dementia;dementia risk;Education;Elderly;Evaluation;follow-up;Follow-Up Studies;Health;Health Educators;Health Expenditures;Healthcare;healthy aging;Hearing;Hearing Aids;hearing impairment;hearing loss treatment;Heterogeneity;Impaired cognition;Intervention;Long-Term Effects;Magnetic Resonance Imaging;Measures;Mediator;Medical;Medicare claim;mild cognitive impairment;modifiable risk;novel strategies;Observational Study;older adult;Outcome;Participant;Pathologic;Pathway interactions;Peripheral;Phase;Policies;Population;primary outcome;Randomized;randomized trial;recruit;Rehabilitation therapy;Risk;Risk Reduction;Role;Schedule;Services;Severities;Site;social engagement;Social Functioning;sound;Structure;Technology;Time;Training;treatment effect;Visit;Washington;white matter

PROJECT_TITLE: Long-term effects of hearing intervention on brain health in the Aging and Cognitive Health Evaluation in Elders (ACHIEVE) randomized study


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Pediatric;Prevention

ORG_CITY: NEW HAVEN

ORG_DEPT: PEDIATRICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE  Blood clots are a top contributor of harm in hospitalized children. We previously conducted a clinical trial that suggested that enoxaparin, a blood thinner, may prevent blood clots from a catheter in older children but not in infants. The CRETE Studies will investigate this newly identified difference in the efficacy of enoxaparin against blood clots between older children and infants.

PI_NAMEs: FAUSTINO, EDWARD VINCENT  (contact)

PROGRAM_OFFICER_NAME: JENKINS, TAMMARA L

PROJECT_TERMS: 1 year old;17 year old;Address;Adult;Age;age effect;age related;Anticoagulants;arm;Bayesian Analysis;Bayesian Method;Bayesian Modeling;Biological Markers;Blood coagulation;Catheters;Cessation of life;Child;Child Development;Childhood;Clinical;Clinical Trials;Clinical Trials Design;clinically relevant;Coagulation Process;Critical Illness;Critically ill children;Deep Vein Thrombosis;Development;Dose;Dose Limiting;efficacy evaluation;Enoxaparin;Event;Funding;Generations;Goals;Hemorrhage;Heterogeneity;Hospitalized Child;Hour;improved;Incidence;Infant;innovation;National Institute of Child Health and Human Development;Nested Case-Control Study;Observational Study;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Phase;Plasma;prevent;Prevention strategy;prophylactic;Prophylactic treatment;Randomized;randomized, clinical trials;Research Priority;Risk;Risk Factors;Risk Reduction;Safety;System;Testing;Therapeutic;Thrombin;Thrombosis;Thrombus;treatment as usual;Treatment Efficacy;Ultrasonography;Venous;venous thromboembolism

PROJECT_TITLE: Age-dependent heterogeneity in the efficacy of prophylaxis with enoxaparin against catheter-associated thrombosis in critically ill children

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: RIVERSIDE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: Project Narrative  The goal of this work is to unlock the investigation of enzyme catalytic mechanism at this finest level of structural and chemical detail. The enzyme systems targeted include pyridoxal-5’-phosphate (the bioactive form of vitamin-B6)-dependent enzymes, which have been implicated in health conditions and as targets for treating diseases such as Tay-Sachs, metachromatic leukodystrophy, Parkinson’s, and tuberculosis, and the β-Lactamases, which mediate antibiotic resistance to β-lactam antibiotics such as penicillin derivatives, cephalosporins, and monobactams. Understanding the catalytic mechanism of these enzymes at the atomic/molecular level will provide the necessary chemical details for developing them as important targets and may contribute to improved rational drug design of novel antibiotic, antidiabetic, antimalarial, and other drugs.

PI_NAMEs: MUELLER, LEONARD J (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Acids;Active Sites;Amines;amino acid metabolism;amino group;Anti-diabetic Drugs;Anti-malarials;Antibiotic Resistance;Antibiotics;base;benzimidazole;beta-Lactamase;beta-Lactams;Cephalosporins;Charge;Chemicals;Chemistry;cofactor;computational chemistry;covalent bond;Crystallography;Decarboxylation;Disease;Drug Design;enzyme mechanism;Enzymes;experimental study;Family;Goals;Health;Hydrogen;Hydrogen Bonding;Image;improved;inhibitor;Investigation;Link;Measures;Mediating;Metachromatic Leukodystrophy;Modeling;Molecular;Monobactams;Neutrons;novel;Parkinson Disease;peer;Penicillins;Pharmaceutical Preparations;Positioning Attribute;protonation;Pyridoxal Phosphate;racemization;rational design;Reaction;Resolution;restraint;solid state nuclear magnetic resonance;Structure;success;System;Techniques;Therapeutic;transamination;Tryptophan Synthase;Tuberculosis;Vitamin B6;Work;X-Ray Crystallography

PROJECT_TITLE: NMR crystallography: Imaging active site chemistry and protonation states

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Infant Mortality;Lung;Neonatal Respiratory Distress;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Telehealth

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative This proposal will develop and test LIVEBORN, an innovative mobile health application to reduce newborn mortality by improving bag mask ventilation in low-resource settings. LIVEBORN will collect real-time data on resuscitation events and provide automated feedback both during and after a resuscitation. This research seeks to shift the paradigm for improving bag mask ventilation from simulation-based training to complementary, guided bedside practice.

PI_NAMEs: PATTERSON, JACQUELYN K (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: acceptability and feasibility;Address;Birth;Breathing;Caring;Cessation of life;Clinical;Collaborations;Data;Data Collection;Democratic Republic of the Congo;Depressed mood;design;Development;digital;digital tool;Effectiveness;effectiveness evaluation;Ensure;Evaluation;Event;experience;Faculty;Failure;feasibility testing;Feedback;Focus Groups;Future;global health;Goals;Grant;Health care facility;Health Technology;Heart Rate;heart rate monitor;Hour;Hybrids;implementation science;improved;innovation;Institution;International;Interruption;Intervention;Life;low and middle-income countries;Manikins;Masks;Methods;mHealth;Midwife;Mobile Health Application;mortality risk;Neonatal Mortality;neonatal resuscitation;Newborn Infant;North Carolina;novel;Performance;Phase;pilot test;Preparation;primary outcome;Process;programs;Provider;Public Health Schools;Randomized;randomized trial;Recommendation;relative effectiveness;Research;Resource-limited setting;Resuscitation;secondary outcome;simulation;Technology;Testing;Time;tool;Training;Universities;usability;ventilation

PROJECT_TITLE: An Integrated mHealth Strategy to Improve Newborn Resuscitation in Low and Lower-Middle Income Countries


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Rehabilitation;Rural Health;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: CHARLESTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Veterans are a high risk AUD population and incur persistently limited access to efficacious family AUD treatments. This study will address longstanding gaps in the literature by examining the efficacy of Brief Family Involved Treatment (B-FIT), delivered via telehealth (i.e., videoconferencing), to maximize AUD treatment outcomes among Veterans in VA Substance Treatment and Recovery (STAR). This study will address an urgent public health priority, significantly advance the science in this area, and improve treatment access to reduce the prevalent, deleterious, and costly effects of AUD among Veterans.

PI_NAMEs: FLANAGAN, JULIANNE CHRISTINA (contact)

PROGRAM_OFFICER_NAME: KWAKO, LAURA ELIZABETH

PROJECT_TERMS: Abstinence;Acceleration;acceptability and feasibility;Adherence;Age;alcohol abuse therapy;alcohol availability;Alcohol consumption;alcohol effect;alcohol reinforcement;alcohol use disorder;Alcohols;Appointment;Area;Back;Behavior;Behavioral;Characteristics;Clinic;Clinical;clinical practice;Cognitive Therapy;Collaborations;Communication;comparative efficacy;Complex;cost;Couples;Couples Therapy;Cues;Data;design;Diagnosis;diagnostic criteria;drinking;Economics;Effectiveness;efficacy evaluation;eHealth;Enrollment;Etiology;evidence base;Exclusion;Family;Family Characteristics;Family member;Family psychotherapy;family support;General Population;Goals;Health;health disparity populations;Health Expenditures;Health Services Accessibility;Health Technology;Healthcare Systems;high risk;Home;improved;Individual;Infrastructure;innovation;Intervention;Literature;Manuals;Measures;Mediating;Mediator;Medical Records;meetings;member;Mental Depression;Mental Health;Methods;Mission;Modality;Modeling;National Institute on Alcohol Abuse and Alcoholism;Outcome;Participant;Patients;Persons;pilot trial;Play;Population;Post-Traumatic Stress Disorders;Prevalence;prevent;Procedures;programs;Provider;Psychological reinforcement;Public Health;public health priorities;Qualifying;Randomized;randomized controlled design;Randomized, Controlled Trials;Recovery;Relapse;Research;Rewards;Role;Rural;Rural Community;satisfaction;Schedule;Science;sex;Standardization;Strategic Planning;Symptoms;System;telehealth;therapy design;Time;Translating;treatment as usual;Treatment outcome;treatment program;Treatment Protocols;underserved community;Veterans;Videoconferencing;Woman

PROJECT_TITLE: Evaluating the Efficacy of Telehealth-Delivered Brief Family Involved Treatment (B-FIT) for Alcohol Use Disorder among Veterans

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: OMAHA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CREIGHTON UNIVERSITY

ORG_STATE: NE

PHR: PROJECT NARRATIVE The health effects associated with low-dose arsenic are controversial, and our knowledge of the molecular mechanisms underlying different individuals’ susceptibility to low-dose arsenic is limited. The proposed study will bring mechanistic insights to arsenic, aquaporin 3–induced DNA damage and mutations, highlighting the importance of studying the mechanisms underlying individual susceptibility to low-dose arsenic. This project will also identify potential early genomic biomarkers to predict long-term arsenic toxicology.

PI_NAMEs: XIA, JUN  (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Acute;Advisory Committees;Affect;aquaporin 3;Arsenic;Bioinformatics;Biological;Biological Assay;Cancer Etiology;carcinogenesis;Cardiovascular Diseases;career;career development;Cell Line;Cells;chromatin immunoprecipitation;Chronic;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;college;Colon;Committee Members;Data;Diagnosis;Disease;DNA;DNA Damage;DNA Repair;DNA Repair Disorder;DNA Sequence Alteration;Dose;drinking water;Drug Metabolic Detoxication;Dyes;early detection biomarkers;Early identification;environmental agent;Environmental Carcinogens;Environmental Health;Etiology;exome sequencing;Foundations;Frequencies;Genes;Genetic;Genetic study;Genome engineering;genome sequencing;genomic biomarker;Genomic Instability;Genomics;Geography;Goals;Health;Human;Human Cell Line;Individual;insight;Knowledge;Lead;live cell imaging;Lung;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Measures;Medicine;Mentors;Methods;Modeling;Molecular;Mus;Mutagenesis;mutant;Mutation;Neurodegenerative Disorders;Noise;Organoids;oxidative DNA damage;Persons;Population;Positioning Attribute;Predisposition;Prevention;Production;Protein Family;Proteins;Reactive Oxygen Species;Recurrence;Research;research and development;Research Personnel;Resolution;Risk;risk variant;Role;Signal Transduction;Technology;tenure track;Testing;Tissues;Toxic Environmental Substances;Toxicology;Toxin;Training;Translational Research;water channel;whole genome

PROJECT_TITLE: The Role of Aquaporin 3 in Arsenic-Induced DNA Damage and Mutagenesis


NIH_SPENDING_CATS: Cancer;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Prevention

PHR: Project Narrative Nucleotides, like pyrimidines and purines, do not only provide cells with nucleic acids for growth, but also function as signaling molecules that control tissue inflammation. Although the immunosuppressive role of certain nucleotides is well appreciated in cancer and autoimmune diseases, their relevance in other inflammatory pathologies, like pneumonia, remains unclear. In this project, we will establish that host nucleotide metabolism is critical to prevent from infection caused by pathogens that exploit lung inflammation to persist, like the feared ESKAPE opportunists Pseudomonas aeruginosa and Staphylococcus aureus.

PI_NAMEs: RIQUELME COLET, SEBASTIAN ALEJANDRO (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Animals;Anti-Inflammatory Agents;Autoimmune Diseases;cancer cell;Cell Respiration;Cells;Communicable Diseases;design;Dihydroorotate dehydrogenase;Disease;ecto-nucleotidase;ESKAPE pathogens;Family;Fright;Goals;Growth;Human;Immunity;Impairment;Infection;Infection Control;Infection prevention;Inflammation;Inflammatory;Knowledge;Laboratories;Leukocytes;Lung;lung health;Lung infections;lung injury;lung pathogen;Malignant Neoplasms;Measures;Metabolic;Metabolism;metabolomics;Microbial Biofilms;Mucous Membrane;Multi-Drug Resistance;novel therapeutics;Nucleic Acids;nucleotide metabolism;Nucleotides;Organism;Outcome;oxidation;Oxidative Regulation;pathogen;Pathogenesis;Pathology;Pathway interactions;Physiological Processes;Pneumonia;prevent;Property;Protein Dephosphorylation;Pseudomonas aeruginosa;Pseudomonas aeruginosa pneumonia;Pulmonary Inflammation;Purines;Pyrimidine;Pyrimidines;Reaction;Reactive Oxygen Species;Research;Respiratory Mucosa;response;Role;Route;Signal Transduction;Signaling Molecule;Staphylococcus aureus;Tissues;Toxin;transcriptomics;tumor;Virulence

PROJECT_TITLE: Impact of nucleotide metabolism on bacterial clearance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-X(55)R]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Precision Medicine;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PHR: PROJECT NARRATIVE This application proposes adding the Universities of North Carolina (UNC) and Arizona (UA) as a highly resourced KPMP Recruitment Site, enriched with rural, Black, Hispanic and Indigenous populations, and a particular interest in health equity and environmental health research. We will obtain kidney tissue obtained purely on a research basis, blood, DNA and urine from participants with acute and chronic kidney diseases to perform basic science studies to identify novel markers of different types of disease and the risk for progression, as well as potential targets for therapeutics. An area of focus will also be understanding how neighborhood and environmental risk factors interact with biology to determine the course and outcomes of these kidney diseases.

PI_NAMEs: BROSIUS, FRANK C;MOTTL, AMY  (contact)

PROGRAM_OFFICER_NAME: GIPSON, DEBBIE SUE

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;Address;Affect;All of Us Research Program;Area;Arizona;Basic Science;Bioethics;Biological Markers;Biology;Biomedical Research;Black Populations;Blood;built environment;Chronic Kidney Failure;Clinical Research;Collaborations;Communities;Complex;Consent;cost;Creativeness;Data;diabetic;Disease;DNA;Economics;effective therapy;End stage renal failure;Environmental Exposure;Environmental Health;Environmental Pollutants;Environmental Risk Factor;Ethics;ethnic diversity;Ethnic Origin;experience;Exposure to;Future;Genetic;Geographic Locations;geographic population;Geography;Goals;health care availability;health determinants;health equity;Heterogeneity;Hispanic Populations;Human;hypertensive;Infrastructure;interest;Interventional radiology;Kidney;kidney biopsy;kidney disease education;Kidney Diseases;Latinx population;Mexican Americans;Native-Born;Natural History;Neighborhoods;Nephrology;North Carolina;novel;novel marker;Outcome;Participant;Pathogenesis;Pathologic;Patient Recruitments;Patients;Physical environment;Population;Population Heterogeneity;precision medicine;Prevalence;Productivity;progression risk;Protocols documentation;Race;racial diversity;recruit;Research;Research Personnel;research study;Resources;Risk;Rural;Rural Population;Safety;screening;Severities;Site;social;social health determinants;socioeconomic diversity;socioeconomics;System;targeted treatment;Tissues;tool;Transportation;Underrepresented Populations;United States;Universities;urban area;Urine;volunteer;Vulnerable Populations;Writing

PROJECT_TITLE: Geographic and Environmental Health Equity in Kidney Precision Medicine


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Genetics;Human Genome

ORG_CITY: PHILADELPHIA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: NARRATIVE Ants exhibit highly evolved eusocial behaviors including stark division of labor among female castes, where the queen carries out all reproduction and worker castes forage for food and defend the colony. Interestingly, and of great relevance to aging research, the sterile workers are short-lived, while the reproductive queens are long-lived, with lifespans differing three to ten-fold between queen and worker. We propose to utilize ants to investigate the epigenetic and physiological basis of the dramatic lifespan differences between reproductive and worker castes.

PI_NAMEs: BERGER, SHELLEY L (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: age related;Aging;aging mechanism;Animal Model;Ants;Behavior;Binding;Biological Models;Castes;Chromatin;Complex;Disparity;Ectopic Expression;Epigenetic Process;epigenetic regulation;epigenomics;Etiology;Excision;Exhibits;extend lifespan;Family;Female;Food;Funding;Genetic;Genetic Transcription;Genome;Genomics;Goals;Heart;Heat shock factor;Heat Stress;Heat-Shock Response;Heat-Shock Transcription Factor 2;Histone Acetylation;histone methylation;HSF1;human model;Individual;Insecta;Investigation;Knowledge;Life;life span;Link;Longevity;Mammals;Messenger RNA;MicroRNAs;Minor;Modeling;mortality;non-genetic;novel;Pathway interactions;Physiological;programs;protein structure;Proteins;Proteomics;Regulation;Reproduction;reproductive;Research;Role;Social Behavior;Soldier;Sterility;Stress;Testing;transcription factor;Translating;Up-Regulation

PROJECT_TITLE: Epigenetic regulation of extreme longevity differences in ant castes

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_CITY: RICHMOND

ORG_DEPT: DENTISTRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: The high concentrations of nitrite in oral cavity as well as the nitric oxide released by inflamed periodontal tissues pose serious threat to survival of a periodontopathogen Porphyromonas gingivalis; therefore adaptation mechanisms to nitrosative stress are necessary for successful establishment and survival of the organism. So far our understanding of the adaptive and regulatory mechanisms governing this adaptation in P. gingivalis is rudimentary and the molecular, genetic, proteomic, structural and cellular approaches that I propose are expected to illuminate the mechanisms of Porphyromonas gingivalis adaptation to nitrosative stresses. This work is guided by the conviction that a cellular and molecular understanding of adaptation of P. gingivalis to nitrosative stress will give way to novel translational approaches for both treating and preventing adult periodontal disease.

PI_NAMEs: LEWIS, JANINA P (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Accounting;Adult;Anti-Bacterial Agents;Bacteria;Biochemical;biological adaptation to stress;Cells;Characteristics;Complex;convict;Cytoplasm;Data;Defense Mechanisms;design;Detoxification Process;DNA;Environment;flexibility;Genes;Genetic;Growth;Heme;Hemin;Human;insight;Knowledge;Length;Mediating;microorganism;Molecular;Nitric Oxide;nitric oxide reductase;Nitrites;nitrosative stress;novel;Oral;oral bacteria;Oral cavity;Organism;pathogen;Periodontal Diseases;periodontopathogen;Porphyromonas gingivalis;prevent;Proteins;Proteomics;Regulation;response;Role;Sigma Factor;Signal Pathway;Signal Transduction;structural biology;Structure;System;Therapeutic Agents;Tissues;tool;Toxic effect;translational approach;weapons;whole genome;Work

PROJECT_TITLE: Nitrosative Stress and Oral Bacteria

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SIOUX FALLS

ORG_NAME: SANFORD RESEARCH/USD

ORG_STATE: SD

PHR: Project Narrative Most cells in the human body, including neurons, have an antenna-like projection called the primary cilium. When this tiny organelle does not function properly, this causes abnormal development and human disease, commonly called `'ciliopathies''. The proposed research program aims to understand how cells form their cilia and fine-tune their roles, as well as how specialized neuronal cells use their cilia to control brain function.

PI_NAMEs: LOUKIL, ABDELHALIM  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Brain;brain control;Cell Physiology;Cells;Cellular biology;Cilia;ciliopathy;cilium biogenesis;Cues;Defect;Development;Embryonic Development;Foundations;Functional disorder;G-Protein-Coupled Receptors;Goals;Homeostasis;Human body;human disease;Impaired cognition;interdisciplinary approach;Knowledge;Microscopy;Modeling;Molecular;Molecular Biology;Morphology;mouse model;Neurologic;Neurons;neurotransmission;novel;Organ;Organelles;Pathway interactions;Process;programs;Regulation;Research;Role;screening;Second Messenger Systems;Sensory;Signal Transduction;Sonic Hedgehog Pathway;Syndrome;Therapeutic;Tissues

PROJECT_TITLE: Identifying regulatory networks that govern primary cilia remodeling and neural signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-L(55)R]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Membrane curvature sensing is a crucial initiation step for many cellular processes, such as membrane trafficking. Defects in membrane traffic underlie diverse diseases such neurological disorders and cancer, thus making the proposed research relevant to public health. Research on basic biophysical mechanisms involved in membrane traffic is relevant to the part of NIH’s mission that seeks to develop fundamental knowledge that will reduce burdens of human disease.

PI_NAMEs: ZENO, WADE F (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: 3-Dimensional;Adsorption;Affect;Behavior;Binding;Biological;Biophysical Process;Biophysics;Cell Physiology;Defect;Disease;Endocytic Vesicle;Environment;Equilibrium;Fluorescence Microscopy;Goals;Human;human disease;interest;Kinetics;Knowledge;Laboratories;Literature;malignant neurologic neoplasms;Measurement;Measures;Membrane;Membrane Protein Traffic;millisecond;Mission;Nervous System Disorder;Phase;programs;protein aggregation;Protein Engineering;protein structure;Proteins;Proteome;Public Health;Research;Research Project Grants;sensor;Signal Transduction;Structure;Surface;Synaptic Vesicles;System;Techniques;Testing;Thermodynamics;three dimensional structure;trafficking;two-dimensional;United States National Institutes of Health;Visualization;Work

PROJECT_TITLE: Dynamic Interactions between Intrinsically Disordered Proteins and Curved Membrane Surfaces


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Prevention

ORG_CITY: LYON

ORG_COUNTRY: FRANCE

ORG_FIPS: FR

ORG_NAME: INTERNATIONAL AGENCY FOR RES ON CANCER

PHR: Narrative The Programme of IARC Monographs on the Identification of Carcinogenic Hazards to Humans identifies the preventable causes of cancer by convening expert working groups to conduct authoritative, internationally respected evaluations of suspected carcinogens, encompassing chemicals, physical and biological agents, complex mixtures, environmental and occupational exposures, and other exposures of everyday life. The resulting IARC Monographs are made freely available online to the public, and results are also disseminated through the scientific literature and other media. The IARC Monographs provide governments and health agencies worldwide with timely, trustworthy, authoritative scientific information to support actions to prevent cancer through control of exposure to known, probable, and possible human carcinogens.

PI_NAMEs: SCHUBAUER-BERIGAN, MARY K. (contact)

PROGRAM_OFFICER_NAME: LAM, TRAM K

PROJECT_TERMS: Achievement;Animal Experiments;Attention;Biological Products;Cancer Control;carcinogenicity;Carcinogens;Characteristics;Chemicals;Classification;Collaborations;Complex Mixtures;Conflict of Interest;Consensus;Country;Data;digital technology;diversity and inclusion;Electronics;Ensure;Environmental and Occupational Exposure;Evaluation;evidence base;experience;exposed human population;Exposure to;Freedom;Funding;Geographic Locations;Goals;Government;Guidelines;hazard;Health;health assessment;health organization;Human;improved;Income;interest;International;International Agency for Research on Cancer;Life;lifestyle factors;Literature;low and middle-income countries;Malignant Neoplasms;Measures;meetings;Methodology;Methods;Modernization;Molecular Epidemiology;Monograph;National Toxicology Program;news;novel;novel strategies;Occupational Exposure;Play;prevent;Preventable cancer cause;Printing;Probability;Procedures;Process;programs;Public Health;public health relevance;Publications;Research;Role;Science;Scientific Evaluation;screening;searchable database;Social Network;Source;Stream;Support Groups;System;systematic review;tool;Toxicology;trustworthiness;U-Series Cooperative Agreements;United States Environmental Protection Agency;web-based tool;working group;World Health Organization


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Mutations in FOXP3 cause loss of functional regulatory T (Treg) cells and the severe early onset autoimmune disease, immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX). IPEX presents exclusively in males, has limited and suboptimal treatment options, and without treatment, is rapidly fatal. We will perform a phase 1 clinical trial to test safety and feasibility of an innovative gene therapy, CD4LVFOXP3, aimed specifically at providing functional autologous Treg-like cells as a treatment for patients with IPEX; at the same time, this trial will provide information on pharmacokinetics and pharmacodynamics of CD4LVFOXP3, instrumental for further clinical trials in IPEX and other rare or more common autoimmune diseases.

PI_NAMEs: BACCHETTA, ROSA  (contact)

PROGRAM_OFFICER_NAME: PIAO, YUNSHANG

PROJECT_TITLE: Phase 1 Study of Autologous CD4LVFOXP3 in Participants with IPEX Syndrome [revised IND and clinical protocol to be submitted to FDA by 10/11/2021]


ORG_CITY: ANCHORAGE

ORG_NAME: ALASKA NATIVE TRIBAL HEALTH CONSORTIUM

ORG_STATE: AK

PHR: Project Narrative The proposed NARCH XII program at the Alaska Native Tribal Health Consortium (ANTHC) is designed to further ANTHC’s work to reduce health disparities in the Alaska Native population and to improve the capacity of ANTHC and our partners to conduct tribally-driven health research. The center includes an Administrative Core, a capacity building project and a research project, all designed in partnership with communities and tribal organizations to address needs identified in the Alaska Native population. In the long-term, the program is expected to have a lasting impact and improve ANTHC’s ability to fulfill its vision that “Alaska Native people are the healthiest people in the world.”

PI_NAMEs: FERUCCI, ELIZABETH D (contact)

PROGRAM_OFFICER_NAME: BISSONETTE, GREG

PROJECT_TERMS: Address;Alaska;Alaska Native;Alaska Native population;Area;career development;Communities;Community Health;community organizations;community research;Consultations;design;Development;disease disparity;Disparity;education research;Ensure;Environment;Environmental Risk Factor;experience;Eye;Fostering;Goals;Growth;Health;health disparity;health organization;Health Priorities;Health system;Hygiene;improved;Indigenous;Intervention;Mentors;Mentorship;Native American Research Center for Health;novel;Outcome;Personal Satisfaction;Persons;programs;Reduce health disparities;Research;Research Personnel;Research Project Grants;rural Alaska;Sanitation;Services;success;tribal health;tribal organization;Tribally Based Participatory Research;Tribes;Universities;Vision;Water;Work

PROJECT_TITLE: ANTHC NARCH XII


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Machine Learning and Artificial Intelligence;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_DEPT: PSYCHOLOGY

PHR: PROJECT NARRATIVE The heterogeneity of major depression presents a problem for effective treatment. We propose to use a combination of lab- and smartphone-based data collection to describe the quantitative relationship between brain network connectivity, computational models of behavioral and affective dynamics, and depressive symptoms over multiple months. We will use theory- and data-driven approaches to elucidate the neurocomputational mechanisms underlying heterogeneity in the symptoms of major depression.

PI_NAMEs: RUTLEDGE, ROBB BROOKS (contact)

PROGRAM_OFFICER_NAME: FERRANTE, MICHELE

PROJECT_TERMS: Affect;Affective;Amygdaloid structure;Anhedonia;Anterior;Behavior;Behavioral;Behavioral Assay;Behavioral Model;behavioral phenotyping;Biological Assay;Brain;Cellular Phone;Clinical;common symptom;Communities;Complement;Computer Models;Corpus striatum structure;cost;Data;Data Collection;Decision Making;depressive symptoms;Diagnostic;Dimensions;Disease;effective therapy;Environment;experience;Functional Magnetic Resonance Imaging;Heterogeneity;improved;Individual;Intervention;Learning;Life;Link;long short term memory;Magnetic Resonance Imaging;Major Depressive Disorder;Maps;Measures;Mental Depression;Mental disorders;Modeling;Moods;MRI Scans;neural circuit;Neural Network Simulation;neuroimaging;Parameter Estimation;Patient Self-Report;Patients;Persons;Phenotype;Policies;Positive Valence;Prevalence;Process;Psychological reinforcement;recruit;recurrent neural network;remote grading;Reporting;Research Domain Criteria;Rest;Rewards;Risk;Sampling;simulation;sleep quality;Statistical Models;success;Symptoms;System;Testing;theories;Time

PROJECT_TITLE: Remote computational phenotyping of behavioral and affective dynamics in major depression


NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PROJECT_TERMS: Alaska;Alaska Native population;Area;career development;Collaborations;Consultations;design;Development;Education;Ensure;Ethics;Evaluation;Funding;Goals;Grant;Health;health organization;improved;Indigenous;Mentors;Mentorship;Native American Research Center for Health;Outcome;Personal Satisfaction;Persons;Process;programs;Reduce health disparities;Research;Research Personnel;Research Project Grants;resilience;Review Committee;Role;Structure;success;tribal health;Tribally Based Participatory Research;Tribes;Vision;Work

PROJECT_TITLE: NARCH XII Admin-Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BDCN-N]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research

PI_NAMEs: EICHELBERGER, LAURA P (contact)

PROJECT_TERMS: 12 year old;Address;Affect;Alaska;Alaska Native;American Indians;Arctic Regions;Categories;Child;climate change;Collection;Communities;community engagement;COVID-19 pandemic;Data;Defecation;design;Disease;disease disparity;disparity reduction;Dryness;Elderly;Engineering;Enrollment;Evaluation;Feces;follow-up;foot;Funding;gastrointestinal infection;Goals;Handwashing;Health;health organization;Home;Household;Human;Hygiene;Impact evaluation;improved;Incidence;Indigenous;Individual;Infection;infection rate;Infectious Skin Diseases;Infrastructure;Intervention;Lived experience;Longitudinal Studies;Maintenance;Measures;men;Methods;Native American Research Center for Health;Native Americans;novel;Outcome;Personal Satisfaction;Persons;Pilot Projects;Plumbing;portability;post-COVID-19;Prevalence;Privacy;Prospective cohort;Public Health;Quality of life;Reporting;respiratory;Respiratory Tract Infections;response;Running;Sample Size;Sanitation;Seasons;Security;Services;Smell Perception;Stress;Symptoms;System;Testing;Time;tribal health;Tribes;Urine;Waste Management;wasting;Water;water treatment;Woman;Work;World Health Organization

PROJECT_TITLE: Evaluation of the Portable Alternative Sanitation System (PASS) on In-Home Water Use and Quality of Life


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHESTNUT HILL

ORG_NAME: BOSTON COLLEGE

PHR: PROJECT NARRATIVE This research program aims to develop novel modeling methods, tools, and guidelines to incorporate racialized lived experiences into mathematical models of infectious disease transmission by explicitly modeling structural drivers of racial disparities in infectious disease exposure, susceptibility and severity, and consequences. This work will help inform the development and testing of structural interventions and decision tools to reduce racial disparities in infectious disease outcomes in the United States. This research will lay the groundwork to inform ongoing control of existing and emerging infectious disease pathogens and prevent the unequal health- and cost-related burdens on communities of color.

PI_NAMEs: ABUELEZAM, NADIA NATASHA (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: 2019-nCoV;Accounting;Behavior;Characteristics;Code;Color;Communicable Diseases;Communities;cost;Data;Data Analyses;Development;Disease;disease disparity;Disease Outcome;disease transmission;Emerging Communicable Diseases;Feedback;flexibility;geographic disparity;Geographic Information Systems;Geographic Locations;Goals;Guidelines;Health;Health Food;Household;Housing;in silico;Income;Individual;Inequality;infectious disease model;Influenza;Intervention;Life Cycle Stages;Link;Lived experience;mathematical model;Mathematics;Methods;Modeling;Natural History;novel;Outcome;Output;pathogen;Pattern;Policies;policy recommendation;Politics;Population;Predisposition;prevent;programs;Race;racial disparity;Research;residential segregation;Science;Severities;simulation;social;social determinants;Social Environment;Specificity;Structural Models;Structure;System;Testing;tool;United States;Work

PROJECT_TITLE: Advancing Methods in Infectious Diseases Models: Incorporating Structural Causes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-R(55)R]


PI_NAMEs: JESSEN, CORNELIA M (contact)

PROJECT_TERMS: Academic advising;Address;Alaska;Alaska Native;Alaska Native population;Canada;career development;Collaborations;Communities;Consultations;COVID-19;cultural competence;cultural health;deep learning;Discipline;Education;education research;Educational process of instructing;Educational workshop;Elderly;empowerment;Epistemology;Equity;Ethics;Eye;Fire - disasters;Funding;Future;Goals;graduate student;Growth;healing;Health;health disparity;health inequalities;Health Professional;improved;Indigenous;indigenous community;innovation;Institution;Internships;Knowledge;Learning;Mainstreaming;Mentorship;Native American Research Center for Health;Outcome;Participant;Persons;Process;Production;programs;Research;Research Methodology;Research Personnel;Research Training;resilience;Science;Scientist;student training;Students;System;Training and Education;Training Programs;tribal health;tribal organization;Tribally Based Participatory Research;Tribes;undergraduate student;Universities;Vision

PROJECT_TITLE: Alaska Indigenous Research Program


NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: RALEIGH

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: Narrative The precise integration of stress signals during the establishment of cellular quiescence is crucial to prevent cell proliferation disorders, such as fibrosis and cancer. However, it is unclear how stress responses are integrated during quiescence, in part, because of a lack of methods for simultaneously quantifying multiple stress pathways in single cells. To solve this problem, the proposed work will combine machine learning approaches with six color fluorescent microscopy to reveal the mechanisms by which stress responses coordinate quiescence.

PI_NAMEs: ARGÜELLO-MIRANDA, ORLANDO  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Algorithms;anaphase-promoting complex;Binding;Biochemical;Biochemistry;Bioinformatics;biological adaptation to stress;Biological Assay;Biological Markers;Carbon;career;Cell Cycle;Cell Cycle Arrest;Cell Cycle Progression;Cell Cycle Regulation;Cell Physiology;Cell Proliferation;Cells;Cellular biology;cellular imaging;Cellular Structures;Color;Complement;Computational Biology;computational platform;computer framework;Computing Methodologies;Core Facility;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;Decision Making;Dedications;design;detection of nutrient;Development;Disease;DNA biosynthesis;Environment;experimental study;Failure;Fibrosis;fluorescence imaging;gene repression;genetic approach;Glutamine;Goals;Histone Acetylation;Human;Image;imaging approach;imaging system;Immunoprecipitation;In complete remission;in vivo;Institution;Label;large-scale imaging data;Machine Learning;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Meiosis;Mentors;Metabolic;Methods;Microfluidics;Microscopy;model organism;Molecular;Nitrogen;Nuclear;Nutrient;Nutrient Depletion;Organ;Organism;Pathway interactions;Pattern;Phase;Phosphotransferases;Positioning Attribute;prevent;Process;Proliferating;Property;Protein Biosynthesis;Proteins;Publishing;Reporter;Research;response;Role;Saccharomyces cerevisiae;Signal Pathway;Signal Transduction;single cell analysis;Source;Starvation;Stress;Systems Biology;Techniques;temporal measurement;Testing;Time Series Analysis;Tissues;tool;Training;Transcription Repressor;Visualization;Work;XBP1 gene;yeast genetics

PROJECT_TITLE: Systems biology of quiescence entry


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Data Science;Dementia;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: VILLANOVA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: VILLANOVA UNIVERSITY

PHR: RELEVANCE (See instructions): Developing a mobile application that combines functional near-infrared-spectroscopy (fNIRS) and  electroencephalography (EEG) on one platform that could be used in less expensive and restrictive testing  environments to determine functional brain alterations in patients with mild cognitive impairment (MCI) is  very innovative. Furthermore, utilizing mobile application and developing cutting-edge machine learning  methods, will allow to determine novel functional brain markers that distinguish older adults with MCI from  healthy controls, which in turn can have major impact on knowledge and diagnostic procedures.

PI_NAMEs: HOLTZER, ROEE ;IZZETOGLU, MELTEM  (contact);JIAO, XUN

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: accurate diagnosis;Alzheimer's Disease;Alzheimer's disease risk;Artificial Intelligence;Attention;behavior measurement;Behavioral;behavioral response;Biochemical;Biological Markers;Brain;Brain imaging;Caregivers;Cognitive;cognitive task;cognitive testing;Computer software;cost estimate;Data;Data Analyses;Data Collection;Data Science;Data Set;design;Detection;Devices;Diagnosis;Diagnostic Procedure;Electroencephalography;Electrophysiology (science);Emotional;Environment;executive function;feature extraction;feature selection;Financial cost;Frequencies;functional near infrared spectroscopy;Genetic Markers;handheld mobile device;hemodynamics;Human Experimentation;Human Resources;imaging modality;Impaired cognition;Individual;individualized medicine;innovation;Instruction;Investigation;Knowledge;Learning;Literature;Machine Learning;machine learning method;machine learning model;Memory;Metabolic;Methods;mild cognitive impairment;mobile application;Modality;Modeling;Monitor;multimodal learning;multimodal neuroimaging;multimodality;neural;neuroimaging;neurophysiology;Neuropsychological Tests;novel;older adult;Patients;personalized management;Pharmaceutical Preparations;Prevalence;Procedures;Process;Psyche structure;Research;signal processing;Societies;Statistical Data Interpretation;Stimulus;System;Techniques;Testing;Time;United States;Validation

PROJECT_TITLE: Collaborative Research: SCH: Assessment of Cognitive Decline using Multimodal Neuroimaging with Embedded Artificial Intelligence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-N(50)R]


NIH_SPENDING_CATS: Clinical Research;Kidney Disease;Precision Medicine

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE Kidney diseases affect 37 million Americans, their causes remain incompletely understood and treatments are limited. The Kidney Precision Medicine Project (KPMP) aims to identify new treatments for common causes of kidney disease by ethically collecting kidney biopsies and clinical information to create a kidney atlas with roadmaps describing cell function in health and disease. The Cleveland Chronic Kidney Disease Recruiting Site has been in the KPMP since its inception and will continue to recruit and follow people with chronic kidney disease from hypertension and or diabetes to create a cohort that represents disproportionately affected communities.

PI_NAMEs: O'TOOLE, JOHN F. (contact);POGGIO, EMILIO DANIEL;SEDOR, JOHN R.

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Adherence;Affect;Altruism;American;Atlases;Awareness;Biological Markers;Biomedical Research;Biopsy;Black race;Cell Physiology;Charge;Chronic Kidney Failure;Clinic;Clinical;Clinical Data;clinical phenotype;clinically actionable;cohort;Collection;common treatment;Communication;Communities;community advisory board;community engaged approach;community engagement;community partnership;Complex;Core Biopsy;cost;COVID-19 pandemic;Data;data repository;Data Set;Diabetes Mellitus;Diabetic Nephropathy;Dimensions;Disease;Educational Activities;Electronic Health Record;Eligibility Determination;Enrollment;Ensure;Equity;Ethics;Event;experience;follow-up;Fostering;Funding;Funding Opportunities;Future;Genome;Goals;Health;hispanic community;Hypertension;Individual;innovation;Kidney;kidney biopsy;Kidney Diseases;Medical;Medicine;member;Metadata;minority communities;Molecular;molecular phenotype;molecular scale;Participant;participant enrollment;participant retention;Pathology;patient screening;Patients;Persons;Population Heterogeneity;precision medicine;Protocols documentation;Public Health;Quality Control;recruit;Research;Research Design;Research Project Grants;research study;Research Subjects;Resources;response;Secure;Site;Specific qualifier value;Subgroup;success;synergism;telehealth;Time;Tissue atlas;Tissues;tool;Trust;Variant;virtual;Visit;Work;working group

PROJECT_TITLE: Cleveland Precision Medicine Chronic Kidney Disease Cohort


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: UCSF NORC Overview: Narrative The UCSF-Nutrition and Obesity Research Center (UCSF-NORC) is a highly integrated community of researchers spanning the spectrum from basic research through clinical implementation of new treatments. To achieve this, the NORC supplies, coordinates and oversees facilities and programs that bring these researchers together. Since its implementation four years ago, the NORC has increased the cohesiveness, and enhanced the visibility of nutrition, obesity and metabolism research at UCSF, thereby enabling the development of outstanding, cutting-edge and highly multi-disciplinary studies.

PI_NAMEs: VAISSE, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: Acceleration;Animal Experimentation;Animals;Area;Award;base;Basic Science;Behavioral;Behavioral Research;Biomedical Research;California;Clinical;clinical implementation;Clinical Research;Collaborations;Communities;Dedications;Development;Direct Costs;Disease;Education;Ensure;epidemiology study;Equipment;Evolution;Funding;Future;Genetic;Genomics;Goals;Grant;Growth;Human;human imaging;Image;improved;improved outcome;Individual;Infrastructure;innovation;Institution;Journals;Laboratories;Leadership;Link;Maintenance;Measures;member;metabolic abnormality assessment;Metabolic Diseases;metabolic imaging;Metabolism;Modification;mouse genome;multidisciplinary;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;nutrition;Nutritional Study;Nutritionist;Obesity;obesity treatment;Phase;Prevention;Principal Investigator;programs;Publications;radiologist;Research;Research Personnel;Research Support;Resources;San Francisco;Schools;Science;Scientist;Services;System;Technology;Tissues;Training;Translational Research;United States National Institutes of Health;Universities;Visualization

PROJECT_TITLE: UCSF Nutrition Obesity Research Center


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Cardiovascular;Childhood Obesity;Clinical Research;Endocrine Disruptors;Foodborne Illness;Nutrition;Obesity;Pediatric;Pregnancy;Prevention

ORG_CITY: PROVIDENCE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative Prenatal exposure to perfluoroalkyl substances (PFAS) is ubiquitous in the United States and may increase the risk of adolescent obesity, elevated blood pressure, dyslipidemia, and insulin resistance. Identifying biological markers of these effects is critical to ongoing regulation of PFAS and may reduce the impact of PFAS-related toxicities. This project will use sophisticated analytical chemistry and biostatistical methods to understand the links between prenatal exposure to PFAS mixtures, metabolomic biomarkers, and adolescent cardiometabolic disease.

PI_NAMEs: BRAUN, JOSEPH M (contact)

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: 12 year old;Acceleration;Address;Adolescent;adolescent health;Adolescent obesity;Adult;Affect;Age;Amino Acids;Analytical Chemistry;Animals;Area;Biological;Biological Markers;Biometry;Biostatistical Methods;Blood;blood pressure elevation;Canada;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;Carnitine;Chemical Exposure;Chemicals;Child;Childhood;Cohort Studies;Collaborations;Collection;Commerce;contaminated drinking water;Coupled;critical period;Data;Databases;Diet;dimension reduction;disorder risk;Dissociation;drinking water;Dyslipidemias;early adolescence;early life exposure;Environment;environmental chemical;environmental chemistry;Epidemiologist;Epidemiology;Evaluation;Exposure to;Fatty Acids;Fire - disasters;Food;Food Contamination;Food Packaging;Growth;Health;health assessment;Home;Human;Hypertension;improved;Individual;Industry;innovation;Insulin Resistance;Ions;Knowledge;landfill;late life;Life;Link;liquid chromatography mass spectrometry;manufacture;manufacturing facility;maternal serum;Measures;Mediating;Metabolic;Metabolism;metabolome;metabolomics;microbiome;Modeling;neonate;novel;Obesity;obesity risk;Ohio;Oils;Outcome;Pathway interactions;Pediatrics;Persons;Plasma;Poly-fluoroalkyl substances;Populations at Risk;Predisposition;Pregnancy;Pregnant Women;prenatal;prenatal exposure;Productivity;Prospective cohort;Publishing;Recording of previous events;Regulation;Research Personnel;Resolution;response;Risk;Risk Factors;Sampling;Serum;small molecule;Syndrome;Techniques;Testing;Textiles;Time;Toxic effect;Training;United States;Water

PROJECT_TITLE: Gestational PFAS Mixture Exposures, Longitudinal Metabolomic Profiles, and Adolescent Cardiometabolic Health

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


NIH_SPENDING_CATS: Nutrition;Obesity

PROJECT_TERMS: Acceleration;Advisory Committees;Area;base;Basic Science;Biomedical Research;Budgets;California;Clinical;cohesion;Collaborations;Committee Members;Communities;community center;cost;Creativeness;Dedications;Development;Discipline;Education;Effectiveness;effectiveness research;Ensure;Evaluation;Evolution;experience;Fostering;Funding;Goals;Growth;Health;Human;Individual;Infrastructure;innovation;Institution;interdisciplinary collaboration;Interdisciplinary Study;Leadership;Link;meetings;member;Mentors;Metabolic;metabolic abnormality assessment;Metabolism;Methods;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;nutrition;Nutritional;Nutritional Study;Obesity;operation;organizational structure;prevent;Process;programs;recruit;Research;research facility;Research Infrastructure;Research Personnel;Research Support;Resource Sharing;Role;San Francisco;Schools;Services;Specificity;Structure;Technology;United States National Institutes of Health;Universities;Vision;web site

PROJECT_TITLE: UCSF NORC Administrative Core


PI_NAMEs: KANAYA, ALKA M. (contact)

PROJECT_TERMS: Acceleration;adipokines;Anatomy;Anthropometry;Area;Behavior assessment;behavior measurement;biobehavioral measurement;Biological Assay;Biological Markers;Biometry;Body Composition;Body fat;Bone Density;Clinical;Clinical Research;Communities;community organizations;Complex;Consultations;Core Facility;data management;Dedications;Development;Disease;Exercise;Fatty acid glycerol esters;Feedback;First Independent Research Support and Transition Awards;Future;Genetic;Goals;Grant;Growth;Health;Health Services Research;Hormones;Human;Human Microbiome;human subject;imaging facilities;improved;Inflammatory;Infrastructure;innovation;Inpatients;instrument;instrumentation;interest;Laboratories;lean body mass;Lipids;Manuscripts;Measurement;Measures;meetings;member;Metabolic;Metabolic Diseases;Metabolism;Methods;Mus;new technology;novel;Nursing Staff;nutrition;Nutrition Assessment;Obesity;Outpatients;Output;Participant;Patient Recruitments;Performance;Physical activity;Procedures;programs;radiological imaging;Radiology Specialty;recruit;Research;Research Design;research facility;Research Personnel;research study;Research Technics;response;Running;Services;Testing;Tissues;tool;Training;Translational Research;translational study;Venous blood sampling;Visualization;Water

PROJECT_TITLE: Core A: Human Metabolism


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse;Women's Health Research

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECT NARRATIVE The co-occurrence of prenatal alcohol exposure and reduced placental blood flow during pregnancy is a relatively common, yet largely unrecognized problem which can diminish a child’s ability to focus and learn later in life. This research project will employ a novel preclinical model combining moderate prenatal alcohol exposure and acutely decreased placental blood flow to investigate the adverse consequences of these combined prenatal insults on frontal cortical brain structure and functions associated with cognition in juvenile offspring.

PI_NAMEs: MAXWELL, JESSIE R. (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: Acute;Adolescent;Adult;adverse outcome;Alcohol consumption;alcohol exposure;Alcohols;Anisotropy;Arteries;Attention;Behavior;Bilateral;Birth Weight;Blood flow;Blood Vessels;Body System;Brain;Brain Injuries;Child;Chronic;cigarette smoking;cingulate cortex;Clinical;Clinical Research;clinically relevant;Cognition;cohort;Complication;Consumption;critical period;density;Diabetes Mellitus;Diffusion Magnetic Resonance Imaging;Disease;Failure;fetal;Fetal Alcohol Exposure;Fetal Growth Retardation;Fetus;frontal lobe;Functional disorder;Golgi Apparatus;Growth;hippocampal pyramidal neuron;histiocyte;Hypoxia;Impaired cognition;Implant;Infant;Injury;insight;Investigation;Ischemia;Knowledge;Language disability;Late pregnancy;Learning;Length;Lesion;Life;Magnetic Resonance Imaging;Measures;Medial;Methods;Microelectrodes;Morbidity - disease rate;Morphology;mortality;Motor disability;neurobehavioral;neurodevelopment;Neurodevelopmental Deficit;Neurological outcome;neuronal patterning;Neurons;novel;Nutrient;offspring;Outcome;Oxygen;Perfusion;Phase;Physiology;Placenta;Placental Insufficiency;postnatal;Pre-Clinical Model;Pregnancy;Pregnant Women;premature;Premature Birth;prenatal;Process;Pyramidal Cells;Radial;Research Project Grants;Risk;Stains;Stimulus;Structure;Task Performances;Testing;thrombotic;touchscreen;Training;Umbilical cord structure;United States;Uterus;Vascular Diseases;vasoconstriction;Vertebral column;Weight;Woman

PROJECT_TITLE: Consequences of combined prenatal alcohol exposure and acute placental ischemia on frontal cortical-sensitive behavior, structure, and physiology in juvenile offspring

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


ORG_CITY: TUCSON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Narrative Worldwide women have a 2-fold greater risk for developing Alzheimer’s disease. The mission of the Perimenopause in Brain Aging and Alzheimer’s Disease Program Project is to discover why women are at greater risk for Alzheimer’s and based on that knowledge, create therapeutic strategies to prevent or delay development of Alzheimer’s disease. Further, our strategy provides a platform for a precision medicine approach to treating Alzheimer’s in both women and men.

PI_NAMEs: BRINTON, ROBERTA EILEEN (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Address;Age;Age Years;aged;Aging;aging brain;Alleles;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;American;apolipoprotein E-4;Autoimmunity;Bioenergetics;Biological;Biological Markers;blood-based biomarker;Brain;Brain imaging;Cells;Cellular biology;Chronology;Clinical;Clinical Sciences;clinical translation;Complex;critical period;design;Development;digital health;Disease;disease phenotype;efficacy evaluation;Endocrine;Endocrinology;endophenotype;Female;Foundations;Genes;Genotype;Goals;health data;Human;imaging program;Immune;Immune response;Immune signaling;Immune system;Immunologic Markers;immunoregulation;Immunotherapeutic agent;Immunotherapy;Intervention;Investigation;Knowledge;late life;Medical Informatics;Medicine;men;menopausal aging;Metabolic;middle age;Mission;Modeling;Molecular;Molecular Biology;mouse model;multimodality;National Institute on Aging;neural;Neuroimmune;Neurosecretory Systems;Organ;Outcome;Perimenopause;Peripheral;pharmacologic;Phenotype;Population;Postmenopause;pre-clinical;Pre-Clinical Model;precision medicine;predictive marker;prevent;Procedures;programs;Quality Control;Reproducibility;Research;Resources;Risk;risk prediction;Role;Science;sex;Site;specific biomarkers;Standardization;System;Systems Biology;Technology;Testing;Therapeutic;Time;Translating;Translational Research;Translations;Treatment Efficacy;Woman

PROJECT_TITLE: Perimenopause in Brain Aging and Alzheimer's Disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Estrogen;Menopause;Neurodegenerative;Neurosciences;Precision Medicine;Prevention;Women's Health Research

PI_NAMEs: MOSCONI, LISA  (contact)

PROJECT_TERMS: Address;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer’s disease biomarker;American;Amyloid beta-Protein;apolipoprotein E-4;Atrophic;Bioenergetics;Biological;Biological Markers;Biology;biomarker signature;Brain;Brain imaging;Chronology;cohort;Core-Binding Factor;cytokine;Development;Endocrine;Endocrinology;endophenotype;Estrogens;Female;Genotype;Goals;Heterogeneity;Image;imaging biomarker;Immune;immune activation;Immune system;Immunophenotyping;Impaired cognition;Inflammation;inflammatory marker;Intervention;Investigation;Life;Link;Magnetic Resonance Imaging;Measures;meetings;Menopausal Symptom;Menopause;Metabolic;metabolomics;middle age;Midlife women;Mission;Mitochondria;National Institute on Aging;Neuroimmune system;Neurosecretory Systems;Onset of illness;Operative Surgical Procedures;Outcome;Perimenopause;Peripheral;Phase;Phenotype;Plasma;Postmenopause;precision medicine;prevent;Prevention;Production;programs;progression marker;Questionnaires;Research;research clinical testing;Risk;risk prediction;Severities;sex;Study Subject;surgical menopause;therapeutic target;Translating;Woman;Women's cohort

PROJECT_TITLE: Project 4: Longitudinal Brain Imaging for Alzheimer's Biomarkers  across Peri to Post Menopausal Transition: Therapeutic Targets and Windows


PI_NAMEs: XU, ALLISON W (contact)

PROJECT_TERMS: Acceleration;Address;Anesthesia procedures;Animals;Archaea;Area;Bacteria;base;behavioral study;blood glucose regulation;Blood Pressure;Body Composition;Body Temperature;Body Water;Bone Density;Bone Mineral Contents;Breeding;Cells;Charge;Collection;Communities;Complement;Complex;Computer software;Conscious;Cultured Cells;Dedications;density;design;Disease;disorder risk;Eating;Effectiveness;Energy Intake;Energy Metabolism;Ensure;epidemiology study;Equipment;extracellular;Extramural Activities;Fatty acid glycerol esters;Feces;feeding;Feeding behaviors;Feeding Patterns;food consumption;Functional disorder;fungus;Gene Modified;Genetic;Genomics;Genus Hippocampus;Germ-Free;Glycolysis;Gnotobiotic;Goals;Grant;Homeostasis;Human;human tissue;Image;in vivo;Incubators;Influentials;innovation;Institution;instrument;instrumentation;Intervention;investigator training;Islets of Langerhans;Laboratory mice;Lipids;Longitudinal Studies;Magnetic Resonance Imaging;Maintenance;Measurement;Measures;member;Metabolic;metabolic abnormality assessment;Metabolic Diseases;metabolic phenotype;metabolic rate;Metabolism;Methodology;Methods;microbiome;microorganism;Microscopic;Mitochondria;model organism;Modeling;Monitor;Motor Activity;Mus;nutrition;Nutritional;Obesity;obesity development;operation;Organelles;Output;Oxygen Consumption;Paper;Parasites;pharmacologic;Physiologic Thermoregulation;Physiological;Physiology;Rattus;Reagent;Reproducibility;Research;Research Methodology;Research Personnel;research study;Resources;Respiration;respiratory;Rodent;Rodent Model;Roentgen Rays;Running;San Francisco;Scientist;Series;Services;Study models;success;System;Technology;Temperature;temporal measurement;Therapeutic;Thinness;Time;Tissue Sample;Tissues;tool;Training;Urine;Virus;Work

PROJECT_TITLE: Core B: Mouse Metabolism and Imaging


PI_NAMEs: REITER, JEREMY F (contact)

PROJECT_TERMS: Acceleration;Affect;Animal Model;Area;base;Bioinformatics;blastocyst;Cell Line;Cells;Chimera organism;Chromosomes;Core Facility;cost;cost effective;Development;DNA;Eating;Embryo Transfer;embryonic stem cell;empowerment;energy balance;Equipment;Evolution;exome;Expression Profiling;Feeding behaviors;gene function;Gene Modified;Gene Mutation;Generations;Genes;Genetic;genetic analysis;genetic manipulation;genomic tools;Genomics;Genotype;Goals;Health;Homeostasis;Human;Individual;Infrastructure;Injections;innovation;INS gene;Institution;instrument;Intervention Studies;Knock-out;Laboratories;Mediating;member;Metabolism;Methodology;Methods;Microinjections;model organism;Modification;Molecular;Mouse Strains;Mutation;next generation sequencing;novel;nutrition;Nutritional;Obesity;Pathway interactions;Physiology;Ploidies;Procedures;Process;Production;programs;repository;Research;Research Personnel;Resources;Sampling;Services;single cell sequencing;skills;Specialist;Technical Expertise;Technology;Testing;Tissues;tool;Training;transcriptome;Transgenic Mice

PROJECT_TITLE: Core C: Genetics and Genomics


NIH_SPENDING_CATS: Clinical Research;Nutrition;Obesity

PI_NAMEs: FELDMAN, BRIAN J (contact)

PROJECT_TERMS: Acceleration;Animal Model;Applications Grants;Area;Award;base;Basic Science;behavioral study;Biomedical Research;Categories;Cells;Clinical;Clinical Research;Collaborations;Collection;Communities;Data;design;Development;diagnostic tool;Discipline;Disease;Elements;Ensure;Extramural Activities;Faculty;Feedback;Fostering;Funding;Funding Opportunities;Future;Genetic;Genomics;Goals;Grant;Growth and Development function;Guidelines;Imaging Techniques;Infrastructure;innovation;Institution;interdisciplinary approach;interdisciplinary collaboration;Intramural Research;member;Mentors;Metabolism;Minority;Mission;Molecular;multidisciplinary;Nature;next generation;notch protein;novel;nutrition;Nutritional Science;Nutritional Study;Obesity;Patients;Pilot Projects;Process;programs;Request for Applications;Research;Research Personnel;Research Project Grants;Scientist;Site;skills;success;Techniques;Therapeutic;tool;web site

PROJECT_TITLE: Pilot and Feasibility Program


PHR: Project narrative: Castleman disease (CD) describes a group of rare hematologic disorders with limited treatment options due to poor understanding of its natural history and disease mechanisms. A team of physicians, researchers, and patients established ACCELERATE, an international, prospective longitudinal natural history study, in 2016 through a 5-year collaborative partnership that has now ended. We are proposing to leverage the data collected to date, build upon infrastructure from this multi-stakeholder collaboration, and continue enrollment and data collection to identify clinically-meaningful patient subtypes, clinical outcome measures, and novel treatment approaches.

PI_NAMEs: FAJGENBAUM, DAVID C (contact)

PROGRAM_OFFICER_NAME: MUELLER, CHRISTINE

PROJECT_TITLE: ACCELERATE: An Efficient and Innovative Natural History Study Addressing Unmet Needs in Castleman Disease


PI_NAMEs: KOLIWAD, SUNEIL KRISHNA (contact)

PROJECT_TERMS: Achievement;Aging;Biology;California;Cementation;Clinical;Clinical Nutrition;clinical practice;Clinical Research;Collaborations;Communication;Communities;continuing medical education;Country;data hub;design;Development;Diabetes Mellitus;Discipline;distinguished professor;Education;Educational Activities;educational atmosphere;Educational Status;Elements;Endocrine;Endocrinology;Environment;Event;Faculty;falls;Fostering;Funding;Future;Goals;graduate school;Grant;Growth;Incentives;innovation;Institution;Joints;Journals;Lead;Learning;lectures;Link;Maintenance;member;Metabolic;Mission;Modeling;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;notch protein;nutrition;Nutritional Study;Obesity;Participant;posters;Principal Investigator;professor;programs;recruit;Research;Research Institute;Research Personnel;Resources;Scientist;Series;Services;Stress;Structure;success;sugar;symposium;Technology;Training;Translational Research;Universities;Visit;Weight

PROJECT_TITLE: Enrichment Program


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE: This research program will use an experimentally tractable model system to investigate how juvenile nutrition influences adult phenotypes. The mechanistic understanding gained from this work can illuminate several processes relevant to human health, including the importance of early-life diet on cardiovascular disease, obesity, and type-II diabetes.

PI_NAMEs: WERNER, MICHAEL S (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Acetylation;adaptive immunity;Address;Adolescent;Adult;Affect;Animal Model;Biochemical;Biochemistry;Biological Models;Cardiovascular Diseases;Chromatin;Development;developmental plasticity;Diet;diet and exercise;dietary;Disease;Environment;Exhibits;experience;experimental study;Exposure to;Gene Expression;Gene Expression Regulation;Genetic Transcription;genome-wide;Genotype;Goals;Health;Heart Diseases;histone modification;Histones;Hormones;Human;insight;Knowledge;Laboratories;Learning;Life;Malnutrition;Metabolic;Metabolic Pathway;Metabolism;Methods;model organism;Modeling;Molecular;Nematoda;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Obesity;Oral cavity;Organism;Pathway interactions;Phenotype;Poison;Postdoctoral Fellow;prenatal exposure;prevent;Process;programs;Regulation;reproductive fitness;Reproductive Health;Research;Role;Signal Transduction;Signaling Molecule;Techniques;tool;Work

PROJECT_TITLE: Chromatin and metabolic regulation of plasticity in a predatory nematode

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Autoimmune Disease;Brain Disorders;Dementia;Estrogen;Genetics;Immunotherapy;Menopause;Neurodegenerative;Neurosciences;Prevention;Women's Health Research

PI_NAMEs: RODGERS, KATHLEEN E. (contact)

PROJECT_TERMS: Address;Affect;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease model;Alzheimer's disease risk;American;Amyloid beta-Protein;Antigen-Presenting Cells;apolipoprotein E-4;Atrophic;Autoimmune;Autoimmune Diseases;Axon;Biological;Blood Cells;Brain;CD80 Antigens;Cellular Immunity;Central Nervous System;Chronology;Clinical;cognitive testing;cohort;cytokine;Databases;Demyelinations;Development;disease phenotype;Endocrine;Endocrinology;endophenotype;Evaluation;Female;Flare;genetic risk factor;Genotype;glial activation;Goals;Healthcare;high risk;HLA-DRB1;Immune;immune activation;immune cell infiltrate;Immunity;Immunization;Immunophenotyping;Impaired cognition;Incidence;Inflammation;Life;Link;Measures;Menopausal Symptom;Menopause;middle age;Midlife women;Mission;mouse model;Mus;National Institute on Aging;Nerve Degeneration;Neuroimmune system;Neurosecretory Systems;oligodendrocyte-myelin glycoprotein;Organ;Outcome Study;Participant;Pathology;Perimenopause;Peripheral;Phenotype;Physiological;Plasma;Postmenopause;prevent;programs;Research;risk prediction;Risk Reduction;Role;serial imaging;single-cell RNA sequencing;Splenocyte;systemic inflammatory response;T-Lymphocyte;Therapeutic Intervention;therapeutic target;Translating;Woman

PROJECT_TITLE: Project 3: Peripheral Immune Activation on the Road to Development of Alzheimer's Disease: Therapeutic Targets and Windows


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Prevention;Women's Health Research

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: PROJECT NARRATIVE Our purpose is to develop a clinical, inexpensive, safe (no ionizing radiation), high resolution, quantitatively accurate breast cancer scanner to address the issue of early identification of breast cancer patients to neoadjuvant chemotherapy. We propose to unite two advanced ultrasound technologies: 1) quantitative transmission ultrasound tomography (QTUS) and 2) Quantitative ultrasound (QUSB) backscatter analysis, the first of which is FDA cleared, into a single device to detect and monitor cancer and its treatment as effectively as MRI and CT without the concomitant danger from radiation or contrast agents. This technology is inexpensive and accurate and addresses the personalized medicine initiative, because it gives quantitative tissue information at the sub-mm level and early feedback on neo-adjuvant cancer therapy for the individual patient.

PI_NAMEs: CZARNOTA, GREGORY JAN;OELZE, MICHAEL L. (contact);WISKIN, JAMES W

PROGRAM_OFFICER_NAME: WU, YICONG

PROJECT_TERMS: 3-Dimensional;Address;Adjuvant Chemotherapy;Anatomy;attenuation;Breast Cancer Patient;Breast Cancer therapy;breast imaging;breast scanner;cancer therapy;chemotherapy;Clinical;Clinical Data;cohort;Contrast Media;cost;Data;data acquisition;Detection;Devices;Disease-Free Survival;Early identification;Early treatment;Feedback;Frequencies;Health Sciences;Human;Image;improved;In complete remission;individual patient;Institution;Ionizing radiation;Knowledge;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Ultrasonography;Mammography;Marketing;Marriage;Measures;Monitor;Neoadjuvant Therapy;Operative Surgical Procedures;Outcome;Pathologic;patient response;Patient-Focused Outcomes;Patients;Performance;personalized medicine;Physical assessment;Process;Prognosis;quantitative imaging;quantitative ultrasound;Radiation;Resolution;response;Savings;Scanning;Signal Transduction;sound;Speed;success;Techniques;Technology;Testing;Time;Tissues;tomography;Translating;transmission process;treatment response;tumor;ultrasound

PROJECT_TITLE: Developing a quantitative ultrasound breast scanner for identifying early response of breast cancer to chemotherapy

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Disability Research;Hearing Loss

ORG_CITY: ROCHESTER

ORG_DEPT: MISCELLANEOUS

ORG_NAME: ROCHESTER INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Deaf and hard-of-hearing (deaf) biomedical research scientists are severely underrepresented among the nation’s biomedical science researchers. The Rochester Bridges to the Doctorate for Deaf and Hard-of- Hearing Students program includes deaf master’s degree seeking students in research-intensive training and professional skill development to prepare these trainees --- who are part of a cultural and linguistic minority group --- for biomedical doctoral programs in preparation to enter biomedical science research careers. This unique partnership between the National Technical Institute for the Deaf at Rochester Institute of Technology and University of Rochester increases representation of deaf biomedical researchers and diversifies the biomedical science research community.

PI_NAMEs: BARNETT, STEVEN L;JACOB, BONNIE C (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: bridge to the doctorate;deaf;hard of hearing;Students

PROJECT_TITLE: Rochester Bridges to the Doctorate for Deaf and Hard-of-Hearing (D/HH) Students (RB2D).

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Menopause;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention;Women's Health Research

PROJECT_TERMS: Address;age related;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Animals;Automobile Driving;Bioenergetics;Bioinformatics;Biological;Biology of Aging;Brain;Brain imaging;brain research;Chronology;Clinical;Clinical Sciences;cloud based;Collaborations;Communication;Communication Tools;Computer Analysis;Data Analyses;Data Analytics;data fusion;data harmonization;data integration;data management;data repository;data sharing;design;digital;disability;Disease;disease prognosis;Ecosystem;Electronics;Endocrinology;endophenotype;Ensure;Female;Goals;Human;Immune system;Immunologic Markers;improved;Information Systems;Infrastructure;insight;Intervention;Laboratories;Lead;Leadership;Medical Informatics;meetings;Metabolic;Midlife women;Mission;Molecular;multiple omics;National Institute of Neurological Disorders and Stroke;National Institute on Aging;Navajo;Neurodegenerative Disorders;Neuroimmune system;Neurologic;Neurosecretory Systems;Outcome;Perimenopause;Phenotype;Population Sciences;Postdoctoral Fellow;pre-doctoral;prevent;Prevention;Prevention strategy;Productivity;programs;Publications;Research;Research Personnel;Research Training;Resources;risk prediction;Role;Strategic vision;success;System;Systems Biology;tool;Translating;Translational Research;Translations;undergraduate student;Woman

PROJECT_TITLE: Administrative


NIH_SPENDING_CATS: Genetics

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Roles of ribonucleic acids for diverse functions in cellular processes continue to be discovered, calling for sophisticated approaches to investigate these central molecules in living cells. Splicing describes the process of diversifying gene expression, and a diverse group of RNAs is involved in this complex process that requires precise regulation in space and time. This proposal aims to expand the toolbox to interrogate ribonucleic acids live in mammalian cells using fluorescence microscopy and use them as the foundation for new insights in splicing function and regulation in health and disease states.

PI_NAMEs: BRASELMANN, ESTHER  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Affect;Alternative Splicing;Biological;Biological Models;Body Composition;Cell model;Cell Nucleus;Cell Physiology;Cells;Complex;Cues;Cytoplasmic Granules;Disease;Disease Management;DNA Sequence Alteration;environmental stressor;Fluorescence;fluorescence lifetime imaging;Fluorescence Microscopy;Foundations;Future;Gene Expression;Gene Expression Regulation;Goals;Health;Human;human disease;Imaging Device;imaging modality;insight;interest;Introns;Investigation;Joining Exons;Label;Link;Malignant Neoplasms;Mammalian Cell;Messenger RNA;Nervous System Disorder;Outcome;Play;Process;programs;Proteins;Reaction;Regulation;Research;Research Personnel;RNA;RNA Splicing;Role;Small Nuclear RNA;spatiotemporal;Spliceosomes;System;Time;tool;Untranslated RNA;Visualization;Work

PROJECT_TITLE: Illuminating multiplexed RNA dynamics to interrogate splicing in health and disease


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Liver Disease;Organ Transplantation;Social Determinants of Health;Substance Misuse;Transplantation

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Alcohol-associated liver disease (ALD) is a major cause of acute and chronic liver failure and is now the most common reason for liver transplantation in the U.S. Historically, transplant centers have required at least 6 months of alcohol abstinence before considering patients with ALD for liver transplant; however early liver transplant for patients with severe ALD with less than 6 months of alcohol abstinence can save lives. This multi- center study will examine the patient selection process for early liver transplantation, identify strategies most helpful to prevent return to alcohol use and to optimize long-term health after transplant.

PI_NAMEs: GHOBRIAL, RAFIK MARK (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Abstinence;Acceleration;access disparities;Accounting;Acute;addiction;Address;Adult;alcohol abstinence;Alcohol consumption;alcohol use disorder;Alcoholic Hepatitis;Alcoholic Liver Diseases;American;Ancillary Study;Behavior Therapy;Behavioral;biobank;Blood;candidate selection;Cardiovascular system;Caring;Cessation of life;Chronic;Cirrhosis;Clinical;Clinical Pathways;clinical predictors;cohort;comorbidity;Consensus;Continuity of Patient Care;Data;data repository;disorder control;drinking;effective therapy;Effectiveness;efficacy evaluation;Eligibility Determination;end stage liver disease;Enrollment;Evaluation;Event;Exclusion;experience;Failure;Future;Geography;graft function;Graft Rejection;Health;health care disparity;Health Status;Heavy Drinking;Hepatitis;Heterogeneity;high risk;Hospital Costs;Hospitalization;implicit bias;improved;Incidence;Individual;Interview;Knowledge;Life;Link;Liver;Liver diseases;Liver Failure;liver transplantation;Longitudinal cohort;Malignant Neoplasms;Medical;medication-assisted treatment;meetings;Mental Health;Methods;Midwestern United States;Modeling;mortality;mortality risk;Multicenter Studies;multilevel analysis;Natural History;Organ;organ allocation;Outcome;Patient Outcomes Assessments;Patient Selection;Patient-Focused Outcomes;Patients;Peripheral Blood Mononuclear Cell;Pharmacotherapy;Phenotype;Policies;prevent;Procedures;Process;Prognosis;Prognostic Factor;prolonged abstinence;prospective;psychosocial;Psychosocial Factor;Quality of life;radiological imaging;recruit;Risk;risk prediction;safety assessment;Sample Size;Selection Criteria;Site;sobriety;social health determinants;Social support;sociodemographics;Sodium Chloride;Source;Standardization;Substance Use Disorder;Systematic Bias;Tissue Donors;Tissues;transplant centers;Transplant Recipients;Transplantation;Transplanted Liver Complication;treatment program;Urine;Waiting Lists

PROJECT_TITLE: 4/4-American Consortium of Early Liver Transplantation-Prospective Alcohol-associated liver disease Cohort Evaluation (ACCELERATE-PACE)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Menopause;Neurodegenerative;Neurosciences;Prevention;Women's Health Research

PI_NAMEs: YIN, FEI  (contact)

PROJECT_TERMS: Address;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease risk;American;Animals;Bioinformatics;bioinformatics tool;Biological;Biological Process;Brain;brain tissue;Cell Nucleus;cell type;Cells;Chronology;Cluster Analysis;Complementary DNA;computerized data processing;Data;Data Analyses;data integration;data repository;differential expression;Endocrinology;endophenotype;Female;Gene Expression Profile;Gene Expression Profiling;Genes;Goals;Informatics;Infrastructure;Link;lipidome;lipidomics;Lipids;meetings;metabolome;metabolomics;Midlife women;Mission;National Institute on Aging;Neuroimmune system;Neurosecretory Systems;Outcome;Pathway interactions;Perimenopause;Peripheral;Phenotype;Plasma;Play;prevent;Primary Cell Cultures;Principal Component Analysis;programs;Proteins;Quality Control;Research;Resources;risk prediction;RNA;Role;Sampling;single nucleus RNA-sequencing;Spleen;Standardization;steroid hormone;System;Systems Biology;tissue processing;Tissue Sample;Tissue-Specific Gene Expression;Tissues;trait;transcriptome sequencing;transcriptomics;Translating;Woman

PROJECT_TITLE: Analytic