NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Cystic Fibrosis;Lung;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: PROJECT NARRATIVE New therapies for cystic fibrosis (CF) have revolutionized clinical care; patients and providers both wish to reduce time-consuming daily maintenance therapies like airway clearance treatment (ACT) that require around 2 dedicated hours per day. Breakthroughs in imaging lung structure and function via MRI allow us to monitor subtle changes in mucus plugs and ventilation, providing a unique opportunity to safely evaluate ACT. We will determine the effectiveness of ACT using MRI via a clinical trial in patients on highly-effective therapies who have stopped and restarted ACT.

PI_NAMEs: AMIN, RAOUF S.;WOODS, JASON C (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Address;Adolescent and Young Adult;Adult;Affect;aged;Bicarbonates;Bronchiectasis;Child;Chlorides;Chronic;clinical care;Clinical Trials;Communities;Community Surveys;Consumption;Cystic Fibrosis;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Dedications;Defect;effective therapy;Effectiveness;effectiveness evaluation;Ethics;Family;Frequencies;Functional Magnetic Resonance Imaging;Gases;Genes;Goals;Hour;Infection;Inflammation;Ion Transport;Ionizing radiation;Lung;Lung Diseases;lung imaging;lung injury;Magnetic Resonance Imaging;Maintenance;Maintenance Therapy;Measurement;Mechanics;Medical;member;Modality;Monitor;Mucociliary Clearance;Mucous body substance;Mutation;novel therapeutics;Obstruction;Patient risk;Patients;Persons;Population;Progressive Disease;Prospective Studies;Proteins;Provider;Pulmonary Cystic Fibrosis;pulmonary function;pulmonary function decline;Pulmonary Function Test/Forced Expiratory Volume 1;Pulmonary function tests;Pulmonary Ventilation;Risk;Safety;Severities;Specificity;Spirometry;Structural defect;structural imaging;Structure;Structure-Activity Relationship;Surveys;Systemic disease;Techniques;Testing;Time;Tissues;tool;treatment response;United States;ventilation;Volition;Withdrawal;X-Ray Computed Tomography

PROJECT_TITLE: Regional monitoring of CF lung disease after changes in mechanical airway-clearance treatment

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Lymphatic Research

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Lymphatic diseases affect 10 million patients in the United States and are understudied. We propose to create a Lymphatic Tissue Mapping Center (TMC) for the NIH Human Biomolecular Atlas Program (HuBMAP) to advance the knowledge of the human lymphatic system.

PI_NAMEs: HONG, YOUNG-KWON ;SINGHAL, DHRUV  (contact);VLACHOS, IOANNIS

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: 3-Dimensional;Affect;Anatomy;Animal Model;Bioethics;California;Cancer Survivorship;Clinical;Collaborations;Communication;Communities;Continuance of life;Data;data dissemination;data integration;data sharing;data submission;Development;Ensure;Future;Generations;Goals;Grant;Health;Human;Human BioMolecular Atlas Program;Human Resources;Indiana;Individual;Infrastructure;Institution;Israel;Knowledge;Leadership;Logistics;Lymph Node Mapping;Lymphatic;Lymphatic Capillaries;Lymphatic Diseases;lymphatic imaging;Lymphatic System;lymphatic vessel;Lymphedema;Lymphoid Tissue;Maps;Medical center;Mission;Operative Surgical Procedures;Patients;Pennsylvania;pharmacologic;Procedures;Process;programs;radiological imaging;Reproducibility;Research Personnel;Resource Sharing;Resources;Sampling;Specimen;Structure;Therapeutic;Three-Dimensional Imaging;tissue mapping;Tissues;transcriptome;transcriptomics;United States;United States National Institutes of Health;Universities;Visualization

PROJECT_TITLE: Multi-scale Spatial Mapping of Human Lymphatic Vessels


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Valley Fever

ORG_CITY: FLAGSTAFF

ORG_NAME: NORTHERN ARIZONA UNIVERSITY

ORG_STATE: AZ

PI_NAMEs: SETTLES, ERIK W (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;accurate diagnosis;Animal Model;Animals;Antibiotics;Antibody Response;Antigens;Arizona;Attenuated;Bacterial Pneumonia;Biological Assay;Breeding;California;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Count;Cell Separation;Cells;Clinical;clinical research site;Clone Cells;Coccidioides;Coccidioides immitis;Coccidioides posadasii;Coccidioidomycosis;Communities;Complex;County;COVID-19;cross reactivity;Cryopreservation;desert fever;Diagnosis;Diagnostic;Diagnostic Procedure;Diagnostic tests;Disease;disease diagnosis;Disease Outcome;DNA;Epitopes;experience;fungus;Future;Goals;HIV Infections;Human;human disease;Immune;Immune response;Immunity;Immunize;immunogenic;immunogenicity;in vivo;Individual;Infection;Life;Link;Macaca;Macaca nemestrina;Medical;Methods;model development;Modeling;Mus;novel;novel diagnostics;Nucleic Acid Vaccines;pathogen;Patients;Peptide Synthesis;Peptides;Performance;Peripheral Blood Mononuclear Cell;Phenotype;Play;Population;Prevalence;Primates;Privatization;Productivity;Proteins;pulmonary symptom;rapid diagnosis;receptor;Reporting;Research Project Grants;Resources;response;Risk;RNA;Role;Sampling;Serology;Serum;Sorting;Specimen;Symptoms;T cell receptor repertoire sequencing;T cell response;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Epitopes;Techniques;Test Result;Testing;Universities;Vaccinated;Vaccination;vaccine candidate;vaccine development;vaccine strategy;vaccine-induced immunity;Vaccines;Viral Pneumonia;Virulence;Virulent;Washington;Whole Blood;Work

PROJECT_TITLE: Early in vivo expressed antigens and their role in virulence, immune response, and vaccines for coccidioidomycosis


ADMINISTERING_IC: ES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Endocrine Disruptors;Estrogen

ORG_CITY: WOODS HOLE

ORG_NAME: MARINE BIOLOGICAL LABORATORY

PHR: PROJECT NARRATIVE The endocrine disruptor field encompasses diverse disciplines and approaches, but there are few opportunities for immersive experiences that help researchers become familiar with the many inter-related aspects of the field. The proposed course will help bridge gaps in this important emerging field by building a firm foundation and forging cross-disciplinary links among researchers from across career stages and types of institutions.

PI_NAMEs: HUNT, PATRICIA ;HYMAN, LINDA E (contact);RUDERMAN, JOAN V

PROGRAM_OFFICER_NAME: GARTON, AMANDA E

PROJECT_TITLE: Endocrine-Disrupting Chemicals: Hazards and Opportunities (ECHO)


PI_NAMEs: FULLER, DEBORAH H. (contact)

PROJECT_TERMS: 2019-nCoV;Animal Model;Animals;Antibodies;Antigen Presentation;Antigens;Area;arid land;Attenuated Vaccines;Biotechnology;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cellular Immunity;Central America;Clinical;Clinical Research;Clinical Trials;Coccidioides;Coccidioidomycosis;Collaborations;Communicable Diseases;community acquired pneumonia;COVID-19;desert fever;design;Development;Disease;DNA;DNA Vaccines;epidemiology study;Exhibits;experimental study;Genetic;Geography;Goals;Health;high risk;Human;Humoral Immunities;Immune;Immune response;Immunity;immunogenic;immunogenicity;Immunologic Stimulation;in vivo;Incidence;Individual;Infection;Influenza;influenza virus vaccine;Lead;lead candidate;Licensing;Macaca nemestrina;Mexico;MHC Class I Genes;Modeling;mouse model;Mucous Membrane;Mus;nonhuman primate;novel;Nucleic Acid Vaccines;Nucleic Acids;Pathogenesis;Play;Pneumonia;pre-clinical;Pre-Clinical Model;Predisposition;protective efficacy;Proteins;Rapid screening;Regimen;Research Project Grants;Risk;RNA;RNA vaccine;Role;Safety;South America;Speed;success;T cell response;T-Lymphocyte Epitopes;Technology;tool;Universities;Vaccination;vaccination outcome;Vaccine Antigen;vaccine candidate;vaccine delivery;vaccine development;vaccine platform;vaccine strategy;vaccine trial;Vaccines;Virulence;Virulence Factors;virulence gene;Washington


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Prevention

ORG_CITY: Chicago

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Currently, there are no approved treatments for NASH, making this a major unmet clinical need. While dynamic changes in liver macrophage subsets during the pathogenesis of NASH, link these shifts to pathologic tissue remodeling, macrophages also have potential to reduce steatosis and fibrosis, an aspect of macrophage function that has been understudied in NASH. Our incomplete understanding of the balance between pro- and anti- steatotic and fibrotic macrophages in NASH is a critical knowledge gap. Thus, the significance of this proposal lies in the delineation, of the not previously known, protective role of osteopontin in macrophages in NASH.

PI_NAMEs: NIETO, NATALIA  (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Adipose tissue;Adult;ARG2 gene;Bioenergetics;Body Fluids;cell behavior;Cell Physiology;Cells;Child;Cholesterol;Clinical;Collagen;Data;Deposition;Development;Diet;Embryo;Equilibrium;Event;Extracellular Matrix;Fatty acid glycerol esters;fatty acid oxidation;Fatty Liver;feeding;Fibrosis;Fructose;Gene Expression Profile;Hepatic;Hepatic Stellate Cell;Hepatocyte;Heterogeneity;Human;Human Milk;Immune system;Infant;Infiltration;Inflammatory;intercellular communication;Intervention;Knock-in;Knockout Mice;Knowledge;Kupffer Cells;Laboratories;Link;lipid metabolism;lipidomics;Lipids;Liver;Liver diseases;Liver Fibrosis;liver transplantation;Location;Macrophage;Messenger RNA;Mitochondria;Modeling;monocyte;Monounsaturated Fatty Acids;mRNA Expression;Mus;Myeloid Cells;Nitric Oxide;nitrosative stress;nonalcoholic steatohepatitis;novel therapeutics;Obesity;osteopontin;overexpression;Pathogenesis;Pathologic;Pathway interactions;Patients;Phenotype;Physiological Processes;Plasma;prevent;Preventive;Production;promoter;Proteins;recruit;Regimen;Regulator Genes;Role;Saturated Fatty Acids;Signal Transduction;Signaling Protein;single-cell RNA sequencing;Testing;Therapeutic;therapeutic evaluation;Tissues;transcriptome;transcriptomics;Triglycerides;Umbilical cord structure;Up-Regulation;urea cycle

PROJECT_TITLE: Protective role of OPN-High macrophages in NASH

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-A(04)]


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The purpose of the Yale Cooperative Center of Excellence in Hematology (YCCEH) is to facilitate and enhance research in blood diseases by facilitating synergy between many different scientists both within Yale and at multiple academic institutions across the country. The Center will help these scientists by providing access to and training in state-of-the-art technologies. Our unique focus is the application of emerging technologies to better understand blood diseases. The center will play a key role in the integrated program of blood disease research supported by other Cooperative Centers of Excellence in Hematology by providing opportunities to increase interactions and collaborations.

PI_NAMEs: HWA, JOHN ;KRAUSE, DIANE S (contact)

PROGRAM_OFFICER_NAME: NORTON, JENNIFER MICHELLE

PROJECT_TERMS: Area;base;Bioinformatics;Biology;Biomedical Research;Blood Cells;Blood Platelets;Bone Marrow;Cell Communication;Cells;Cellular biology;clinical center;clinical investigation;Collaborations;Core Facility;cost effectiveness;Country;Development;Disease;Education;Educational process of instructing;Emerging Technologies;Environment;Erythrocyte Transfusion;Faculty;gene function;genome analysis;Genomics;Goals;Hematological Disease;Hematology;Hematopoiesis;hematopoietic differentiation;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Image;improved;Inherited;innovation;Institution;interest;Leadership;Learning;Medical center;Medical Informatics;medical schools;member;Microscopy;Molecular Biology;National Institute of Diabetes and Digestive and Kidney Diseases;new technology;next generation;Non-Malignant;novel therapeutic intervention;Performance;Play;Process;progenitor;programs;Proteins;Proteomics;Regulation;Research;Research Personnel;Research Support;Resources;RNA;Role;Scientist;self-renewal;Signal Transduction;stem cell biology;stem cells;synergism;Systems Biology;Techniques;Technology;Training;Training Activity;Training and Education;Universities


NIH_SPENDING_CATS: Clinical Research;Hematology;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta - Non-Human

PI_NAMEs: KRAUSE, DIANE S (contact)

PROJECT_TERMS: Address;Area;Awareness;Bioinformatics;Budgets;Categories;CD34 gene;cell preparation;Cells;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;cost;cost effective;design;Discipline;Emerging Technologies;experience;Faculty;Funding;Gene Library;genome editing;Genomics;Goals;Hematology;Hematopoiesis;Human;Individual;innovation;Institution;interest;Laboratories;Laboratory Research;manufacture;member;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Malignant;Paper;Patients;Persons;Population;Preparation;prevent;Price;Protocols documentation;Publications;Reproducibility;Research;Research Personnel;Research Technics;Resources;Sampling;Services;single cell genomics;Specimen;stem;stem cells;success;synergism;Techniques;Technology;Time;Tissue Banks;Training;Universities;Virus

PROJECT_TITLE: Cell Preparation and Analysis Core


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Infectious Diseases;Machine Learning and Artificial Intelligence;Malaria;Networking and Information Technology R&D (NITRD);Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because long-lasting insecticidal bednets are the backbone of malaria prevention and all 3 billion people affected by malaria world-wide are recommended to use bednets every night. Given worsening malaria trends in Africa, there is an urgent need for novel approaches to charac- terize how bednets are used in actual practice, as our current tools have limited accuracy and do not account for temporal variations in use. This high-risk, high-reward proposal is directly relevant to the NIAID initiative seeking to understand vector-host interactions in disease transmission by developing an innovative and comprehensive tool for measuring LLIN use and related behaviors that may point the way towards better interventions for reduc- ing malaria risk.

PI_NAMEs: KREZANOSKI, PAUL JOSEPH (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Accelerometer;Acting Out;Address;Adoption;Adult;Affect;Africa;Africa South of the Sahara;African;Algorithms;Area;Back;Beds;Behavior;Bite;career;Cessation of life;Child;Classification;classification algorithm;Communities;Community Surveys;Country;Culicidae;Data;Data Set;disease transmission;Electronics;Face;Foundations;Frequencies;Funding;Goals;Health;Height;high reward;high risk;Household;improved;Incidence;innovation;Insecticides;Interruption;Intervention;invention;Investments;Knowledge;Life;machine learning algorithm;Malaria;Malaria prevention;Mattresses;Measurement;Measures;Methods;Monitor;Motion;National Institute of Allergy and Infectious Disease;neural network;new technology;next generation;novel;novel strategies;Observational Study;Participant;Patient Self-Report;Pattern;Performance;Persons;prevent;Protocols documentation;Public Health;pyrethroid;random forest;Recommendation;recruit;remote monitoring;Reporting;Research;Research Methodology;research study;Resistance;response;Risk;Role;scale up;sensor;Shapes;Sleep;Surveys;System;Testing;Time;time use;tool;Training;trend;Uganda;Variant;vector;Vertebral column;Video Recording;Work

PROJECT_TITLE: Training of machine learning algorithms for the classification of accelerometer-measured bednet use and related behaviors associated with malaria risk

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


NIH_SPENDING_CATS: Hematology

PHR: Project Narrative  Administrative Core Yale Cooperative Center of Excellence in Hematology The Administrative Core of the Yale Cooperative Center of Excellence in Hematology (YCCEH) will provide the administrative structure for the YCCEH Activities include organizing activities, maintaining the budget, organizing travel and conferences, and keeping the website of the YCCEH up to date.

PROJECT_TERMS: Accountability;Administrative Personnel;Annual Reports;Applications Grants;Award;base;Biomedical Research;Blood Cells;Budgets;Cell Differentiation process;Collaborations;Communication;Communities;Core Facility;Data;Development;Educational workshop;Ensure;Face;gene function;Goals;Grant;Hematology;Hematopoiesis;Human Resources;Individual;innovation;Joints;Leadership;Maintenance;meetings;member;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Malignant;Office Management;Participant;Process;Productivity;progenitor;programs;Proteins;Publications;Records;Regulation;Research;Research Personnel;Schedule;Scientist;Services;social media;stem cell biology;stem cell proliferation;Structure;Suggestion;Supervision;symposium;Travel;United States National Institutes of Health;Universities;Update;Visit;web site;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Rare Diseases

ORG_CITY: HANOVER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative This project elucidates fundamental connections between the cytoskeleton and the dynamics of a major cellular organelle, the mitochondrion, in mammalian cells. As such, the research impacts all cells containing mitochondria but is especially relevant to neurons, due to their long lifetimes, polarized nature and dependence upon mitochondrial respiration. In addition, our recent links between actin and metabolic shifting between aerobic and anaerobic respiration open further possibilities to impact human health. 1

PI_NAMEs: HIGGS, HENRY N (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Actins;Acute;Address;Aerobic;Affect;Biochemical;Biology;Calcium;Cell Physiology;Cells;Charcot-Marie-Tooth Disease;Complex;Cytoskeleton;Cytosol;Dependence;Disease;Endoplasmic Reticulum;fascin;Filament;Filopodia;FMNL1 gene;Focal and Segmental Glomerulosclerosis;frontier;Glycolysis;Goals;Grant;Health;Human;Hypoxia;Link;live cell microscopy;Mammalian Cell;Membrane Lipids;Metabolic;Metabolism;Mitochondria;Modeling;Mutation;Myosin Type II;Nature;Neurons;Organelles;Parkin;Pathway interactions;pharmacologic;polymerization;Polymers;Process;Protein Kinase;Protein Kinase C;protein purification;Proteins;Proteomics;reconstitution;recruit;Research;Respiration;STK11 gene;Stress Fibers;Structure;Work

PROJECT_TITLE: The impact of dynamic actin polymerization on mitochondrial dynamics and function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: Bioengineering;Hematology

PI_NAMEs: BEWERSDORF, JOERG  (contact)

PROJECT_TERMS: Adhesives;Benign;Biological;career;Cell Cycle;cell type;Cells;cellular imaging;Charge;Complement;Complex;Data;Data Analyses;design;Educational workshop;Electron Microscopy;Ensure;Equipment;Event;Flow Cytometry;Fluorescence;fluorescence imaging;Fluorescence-Activated Cell Sorting;Funding;genetic manipulation;Hematology;Hematopoiesis;Hematopoietic;hematopoietic tissue;Home;Image;Image Cytometry;imaging approach;imaging facilities;imaging modality;imaging platform;Imaging Techniques;incentive program;Individual;innovation;instrument;instrumentation;interest;Investments;Knowledge;Laboratories;Light;live cell microscopy;Measurement;member;microscopic imaging;Microscopy;Molecular;Mouse Strains;novel;operation;Optics;Phototoxicity;Positioning Attribute;preference;Preparation;Process;programs;Property;psychologic;Reagent;Reporter;Research;Research Personnel;Research Project Grants;Resolution;Sampling;Scientist;Services;Signal Transduction;Specialist;Students;superresolution imaging;superresolution microscopy;symposium;Technical Expertise;Techniques;Time;Tissues;tool;Training;two-photon;ultra high resolution

PROJECT_TITLE: Imaging Core


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Lymphatic Research;Lymphoma;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_DEPT: CHEMISTRY

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Increased understanding of the molecular mechanisms underlying non-Hodgkin's lymphoma (NHL) demonstrate disparities in lymphoma outcomes in identified African-American (AA) patients and identified them as a poor-risk population, with diagnosis age 10 years younger than other racial groups. The R01 will investigates mechanisms underlying racial disparity AA B cell lymphoma tumor microenvironment and develops tumor organoids. It will examine how AA B cell lymphoma tumor microenvironment differs from that of white patients and determine its impact on oncogenic signaling pathways.

PI_NAMEs: KOFF, JEAN L;SINGH, ANKUR  (contact)

PROGRAM_OFFICER_NAME: DUGLAS TABOR, YVONNE

PROJECT_TERMS: 10 year old;activated B cell like;Address;African American;African ancestry;Agammaglobulinaemia tyrosine kinase;American;American Society of Hematology;Antigens;B-Cell Antigen Receptor;B-Cell Lymphomas;B-Lymphocytes;biobank;Biophysics;Cell Survival;Cells;Chemoresistance;Chromatin;Classification;Clinical;cohort;Complex;Cues;Data;Data Set;Databases;Diagnosis;Disparity;DNA Sequence Alteration;Engineering;epidemiology study;Epigenetic Process;ethnic minority;European ancestry;Exhibits;exome sequencing;experience;Extracellular Matrix;Feedback;Gene Expression;Gene Expression Profile;Goals;Hydrogels;Immune;improved outcome;In complete remission;Indolent;Inferior;inhibitor;innovation;Institution;Integrins;Investigation;large cell Diffuse non-Hodgkin's lymphoma;Ligands;lymph nodes;Lymphoid;Lymphoma;Lymphoma cell;Maintenance;Manuscripts;Mediating;Molecular;mortality;Mutation;neoplastic cell;Non-Hodgkin's Lymphoma;Not Hispanic or Latino;Oncogenic;Organoids;Outcome;outcome disparities;partial response;Pathogenesis;Pathway interactions;Patients;Pattern;PIK3CG gene;Population;population based;Primary Neoplasm;Race;racial determinant;racial difference;racial disparity;racial minority;racial population;Receptor Activation;Receptor Signaling;Refractory;Relapse;Reporting;Research;Research Personnel;Resistance;response;Risk;Role;Sampling;SEER Program;Sgk protein;Signal Pathway;Signal Transduction;Structure of germinal center of lymph node;T-Lymphocyte;targeted treatment;Toll-like receptors;transcriptome sequencing;Translational Research;tumor;tumor growth;tumor microenvironment;Tyrosine Kinase Inhibitor;Work;Xenograft procedure

PROJECT_TITLE: Hydrogel-based Organoids of African-American Lymphomas to Study B Cell Receptor Pathway Inhibitors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Y(55)R]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences;Sleep Research

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: PROJECT NARRATIVE The proposed research will investigate how information processing in the visual system change as our brain state shifts from alert to drowsy and into sleep. Important new knowledge gained from this work will aid mechanistic understanding of the effects of decreased attention on perception, helping the development of tools for preventing "drowsy driving" accidents. It will also inform further research into cognitive disorders caused by impaired attention and/or dysfunction of the regulation of brain state during wake-sleep cycle.

PI_NAMEs: BERESHPOLOVA, YULIA  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Accidents;Action Potentials;Address;Affect;alertness;Anesthesia procedures;Animal Experiments;Animals;Attention;awake;Brain;cell type;Cells;Characteristics;Chronic;Cognition Disorders;Contrast Sensitivity;corticogeniculate;Data;Dependence;Detection;differential expression;Drowsiness;Drowsy Driving;Electric Stimulation;electrical microstimulation;Electroencephalography;Electrophysiology (science);Equilibrium;Evoked Potentials;Exhibits;experimental study;extracellular;Eye Movements;Felis catus;Frequencies;Functional disorder;Goals;Hippocampus;Hour;Human;Impairment;Individual;information processing;Injections;injured;Interneurons;Knowledge;Lateral Geniculate Body;Light;Location;Measures;Mediating;Membrane Potentials;microstimulation;Monkeys;Mus;Neocortex;Neurons;Noise;operation;Oryctolagus cuniculus;Pattern;Perception;Persons;Pharmaceutical Preparations;Photic Stimulation;Physiologic pulse;postsynaptic;prevent;Prevention;Property;Pupil;receptive field;Regulation;REM Sleep;Research;research and development;response;Rest;retinotopic;Safety;sensory input;Site;Sleep;sleep spindle;Sleep Wake Cycle;Slow-Wave Sleep;Stimulus;Structure;Synapses;Testing;Thalamic structure;tool development;Training;V1 neuron;Vision;Visual;Visual Cortex;Visual evoked cortical potential;visual information;Visual Pathways;Visual Perception;visual processing;visual stimulus;Visual System;voltage;Work

PROJECT_TITLE: Cellular Mechanisms of State-Dependent Processing in Visual Cortex

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


NIH_SPENDING_CATS: Clinical Research;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta - Non-Human;Transplantation

PI_NAMEs: FLAVELL, RICHARD A (contact)

PROJECT_TERMS: Animal Model;Basic Science;Benign;Biological Assay;Blood Platelets;Cells;Circulation;Communities;Disease;Educational process of instructing;Erythrocytes;Goals;Hematological Disease;Hematology;Hematopoiesis;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Human;humanized mouse;Immune system;Immunobiology;Immunodeficient Mouse;in vivo;innovation;mid-career faculty;Mission;Modeling;mouse model;Mus;Myeloid Cells;novel;Population;professor;Research;Research Personnel;Resources;Scientist;Stem cell transplant;Study models;Technical Expertise;Technology;Tissues;Training;translational study;Xenograft procedure

PROJECT_TITLE: Animal Modeling Core


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Substance Misuse;Telehealth

PHR: PROJECT NARRATIVE Catheter ablation for atrial fibrillation AF may be the most effective approach to treating the most common sustained abnormality in heart rhythm in the world, but also carries risks of debilitating complications and death. Most of the data on atrial fibrillation ablation arises from carefully constructed randomized trials or from institutions that are highly specialized in the procedure, leaving a deficit in understanding the “real-world” effectiveness and risk that is actually experienced by many patients in the US. In the current proposal, we seek to leverage an existing registry that is already collecting data on atrial fibrillation ablation procedures from hundreds of institutions around the country and utilize a smartphone-app to follow those patients over-time, determining the true effectiveness and risk of the procedure, and the patient, procedure, and institution-level characteristics that may influence those outcomes.

PI_NAMEs: MARCUS, GREGORY M (contact)

PROGRAM_OFFICER_NAME: PUGGAL, MONA A

PROJECT_TERMS: Ablation;Address;administrative database;Alcohol consumption;American;Assessment tool;Atrial Fibrillation;biomedical referral center;Cardiac;Cardiac ablation;Cardiac Electrophysiologic Techniques;Cardiology;Cardiovascular system;Cellular Phone;Cessation of life;Characteristics;Clinical;clinically relevant;college;Complication;Country;Cryosurgery;Current Procedural Terminology Codes;Data;Data Collection;data registry;Databases;Death Rate;digital;digital health;Disease;Effectiveness;effectiveness evaluation;Electrophysiology (science);Enrollment;experience;Female;Fistula;follow-up;Funding;Future;Goals;Guidelines;Health Personnel;heart rhythm;Heavy Drinking;high risk;Hospitalization;Hospitals;ICD-9;implantation;Incidence;indexing;Infrastructure;Institution;interest;International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10);Intervention;Laboratories;Life Style;lifestyle factors;Longitudinal Studies;member;Methods;mHealth;mobile application;National Heart, Lung, and Blood Institute;operation;Outcome;Paper;Participant;participant enrollment;Patient Outcomes Assessments;patient registry;Patients;Procedures;Professional Organizations;prospective;Prospective cohort;Publishing;Quality of life;Radiofrequency Interstitial Ablation;randomized trial;Recommendation;Registries;remote consent;Reporting;Research;Research Personnel;Research Project Grants;Resources;Risk;Running;Safety;secondary analysis;Secure;sex;smartphone application;Sorting;standard of care;symptomatic improvement;Testing;Time;tool;transmission process;United States National Institutes of Health;Visit;women patients;Work

PROJECT_TITLE: Applying Digital Health to the AF Ablation NCDR, Enabling Longitudinal Follow-up

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


PI_NAMEs: HENDRICKSON, JEANNE E (contact)

PROJECT_TERMS: Area;Back;bench to bedside;Benign;Budgets;career;Caring;Clinical;clinical center;clinical investigation;Collaborations;college;Contracts;Dedications;Doctor of Philosophy;Education;Effectiveness;Epidemiology;Evaluation Studies;experience;Financial Support;Funding;Future;Goals;Hematological Disease;Hematology;Hematopoiesis;Individual;Infrastructure;instructor;interest;Investments;Knowledge;Laboratories;Leadership;Learning;medical schools;Mentors;Modeling;National Heart, Lung, and Blood Institute;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;Non-Malignant;novel;Patient Care;Patients;Pediatric Hematologist;Physicians;post-doctoral training;Postdoctoral Fellow;programs;Public Health;Research;Research Personnel;Resources;Science;Scientist;Series;Site;Stem Cell Research;stem cells;student mentoring;symposium;Techniques;Testing;Training;training opportunity;transfusion medicine;Translations;undergraduate student;Underrepresented Minority;underrepresented minority student;United States National Institutes of Health;Universities;Walking

PROJECT_TITLE: Enrichment Core


NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Prevention

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: NARRATIVE This application focuses on defining the biological processes that increase atherosclerotic cardiovascular disease in patients with Type 1 Diabetes. We propose to perform a clinical trial to assess the response of platelets, white blood cells and the blood vessels to robust cholesterol reduction.

PI_NAMEs: GOLDBERG, IRA J (contact)

PROGRAM_OFFICER_NAME: KIRBY, RUTH

PROJECT_TERMS: abdominal aorta;Abnormal Endothelial Cell;Acceleration;American Heart Association;animal data;Animal Model;Arteries;Atherosclerosis;atorvastatin;Biological Markers;Biological Process;blood glucose regulation;Blood Platelets;Blood Vessels;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Carotid Arteries;CD8-Positive T-Lymphocytes;Characteristics;Cholesterol;Clinic;Clinical Research;Clinical Trials;Communities;Continuous Glucose Monitor;Cytometry;Data;Dendritic Cells;Development;Diabetes Mellitus;Endothelial Cells;Epinephrine;Event;experience;ezetimibe;Failure;Female;fluorodeoxyglucose;Gene Expression;Glucose;glycemic control;Glycosylated hemoglobin A;Harvest;Health care facility;human data;Impairment;Individual;Inflammatory;inflammatory marker;Inflammatory Response;inhibitor;Insulin-Dependent Diabetes Mellitus;LDL Cholesterol Lipoproteins;Leukocytes;Low-Density Lipoproteins;Macrophage;male;Measurement;Measures;Medical center;medical schools;men;Methods;mRNA sequencing;neutrophil;New York City;Non-Insulin-Dependent Diabetes Mellitus;Pathologic Processes;Pathway interactions;Patient Recruitments;Patients;Peripheral Blood Mononuclear Cell;PET/CT scan;Platelet aggregation;platelet function;Positron-Emission Tomography;Prediction of Response to Therapy;predictive marker;prevent;Process;process improvement;recruit;repaired;Research;Research Design;Residual state;response;Risk;Risk Reduction;RNA;single-cell RNA sequencing;Subgroup;Techniques;Testing;therapeutic target;Time;transcriptome;treatment response;ultrasound;underserved community;uptake;Vascular Endothelial Cell;vascular inflammation;Veins;Woman

PROJECT_TITLE: Cholesterol reduction and cardiovascular risk in Type 1 diabetes


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cardiovascular;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Hematology;Hypertension;Infectious Diseases;Lung

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: COVID-19 is a multi-organ thrombotic disease and hypertension is a significant risk factor for poor COVID-19 outcomes. We identified renin as an unappreciated agonist for coagulation and platelet activation. Platelets bind and internalize SARS-Cov-2, so rapid clearance of renin-activated platelet-viral complexes will enable viral entry.

PI_NAMEs: MCINTYRE, THOMAS M (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: ACE2;Acute;Affinity;Age;Agonist;Aldosterone;aliskiren;Angiotensinogen;Animals;Autopsy;Binding;Blood;Blood coagulation;Blood Coagulation Disorders;Blood Platelets;Blood Vessels;Blood-Air Barrier;Cardiovascular system;cell injury;Cells;Circulation;Closure by clamp;Coagulation Process;comorbidity;Complex;Consumption;COVID-19;COVID-19 pandemic;COVID-19 patient;COVID-19 prognosis;COVID-19 risk;Denervation;Deposition;Disease;Eating;Endothelial Cells;Endothelium;Essential Hypertension;F2R gene;factor IXa-factor VIIIa;Factor Xa;FDA approved;Fibrin;Fibrinolytic Agents;Fibrosis;Functional disorder;Genetic;German population;heart damage;Heart Injuries;Human;Hypertension;hypertensive;in vivo;Inactive Renin;Incidence;Infection;Inflammation;inhibitor;innovation;intercalation;Kidney;Lentivirus;Ligation;Liver;liver injury;Lung;Lung Diseases;lung injury;Macrophage;Mass Spectrum Analysis;Measures;Mediating;Megakaryocytes;Membrane;multiorgan damage;Mus;Nervous System Trauma;novel;novel strategies;Organ;Outcome;particle;Pathway interactions;Patients;Pattern;Pepstatins;Peptide Hydrolases;Pharmaceutical Preparations;Phosphatidylserines;Plasma;Platelet Activation;Platelet aggregation;prophylactic;prorenin receptor;protein complex;Proteins;Proteolysis;Pulmonary alveolar structure;Rattus;receptor;renal damage;Renin;Reporter;respiratory;Reticuloendothelial System;Risk;Risk Factors;RNA;Role;Route;Severe Acute Respiratory Syndrome;Signal Transduction;Site;Spleen;Surface;System;Testing;Therapeutic;Thrombin;Thrombin Receptor;Thrombocytopenia;Thromboembolism;Thromboplastin;Thrombosis;thrombotic;thrombotic complications;Thrombus;Tissues;TMPRSS2 gene;Transgenic Animals;Transgenic Organisms;Tropism;uptake;vector;Viral;Virus

PROJECT_TITLE: Hypertension augmented COVID-19 through renin-induced internalization of platelet-ACE2 / SARS-Cov-2 complexes

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: Nashville

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE  In this study, we examine the relationship between provider- and policy-level factors on cognitive decline and preventive healthcare use among midlife and older sexual and gender minority (SGM) adults. Using 2015-2019 BRFSS, we examine prevalence, severity, and receipt of informal care for subjective cognitive decline (SCD), a major risk factor for Alzheimer’s Disease, as well as estimate the association of state policies legally permitting denial of health services based on sexual orientation on preventive healthcare use. Using panel data from the NIA-funded Vanderbilt University Social Networks, Aging, and Policy Study (VUSNAPS), we test 7 provider-level attitudes and practices towards SGM patients as predictors of preventive healthcare among midlife and older SGM adults to address inequities in preventive healthcare use.

PI_NAMEs: TRAN, NATHANIEL M (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: Acceleration;Address;Adoption;Adult;Age;age acceleration;aged;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Attitude;Award;barrier to care;Behavioral Risk Factor Surveillance System;care seeking;checkup examination;Chronic;Clinical;colorectal cancer screening;Communities;cooking;Data;Decision Making;dementia risk;design;Discrimination;Disparity;Distress;Education;Employment;experience;Family member;Funding;gender minority group;gender minority health;gender minority health disparity;Health;Health behavior;health determinants;health disparity;health inequalities;Health Personnel;health service use;Health Services;Health Status;Health system;Healthcare;healthy aging;High Prevalence;high risk;Home;Human immunodeficiency virus test;human old age (65+);Illinois;Impaired cognition;Impairment;improved;Inequity;Influenza vaccination;informal care;insight;instrumental activity of daily living;Intervention;Laws;Legal;Lesbian Gay Bisexual Transgender Queer;Life Cycle Stages;Malignant Neoplasms;Measures;Memory;Mental Health;Mentorship;middle age;minority patient;minority stress;Mississippi;novel;older adult;Outcome;Patients;Physicians;Play;Policies;Population;population health;Positioning Attribute;Prevalence;Preventive care;Preventive healthcare;Preventive service;Probability Samples;programs;Provider;Psyche structure;public health research;Reporting;Research;Rights;same-sex marriage;Scholarship;service gap;Services;Severities;sex;Sex Orientation;Sexual and Gender Minorities;sexual minority;sexual minority group;Social Network;Social support;Spouses;Testing;Time;Training;United States;Universities;Vaccination;Work

PROJECT_TITLE: Multi-Level Determinants of Sexual and Gender Minority Aging

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Although many people will use an opiate at some point in their lifetime, only a subset of individuals will develop an opioid use disorder (OUD). Risk for OUD may be linked to specific genetic mechanisms, but the identity of these genes is unknown. This proposal will investigate the genetic mechanisms that are related to differences in opioid-taking behaviors in rats in order to identify genes that mediate risk for developing OUD in humans.

PI_NAMEs: DILEONE, RALPH J (contact);GROMAN, STEPHANIE MARY

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: addiction;Affect;Amygdaloid structure;Animals;ATAC-seq;Behavior;Behavioral;behavioral phenotyping;Biological;Biology;Chromatin;Chronic;Complex;Computer Models;Data;Decision Making;Dependence;differential expression;Dissociation;Drug abuse;drug development;Drug Exposure;Drug usage;Environmental Risk Factor;experimental group;Female;Future;Genes;Genetic;Genetic Identity;Genetic study;genetic variant;Genomic approach;Genomics;Goals;Human;Individual;Individual Differences;insight;Link;male;Mediating;Molecular;Neurobiology;neuromechanism;next generation;Nucleus Accumbens;Opioid;opioid use;opioid use disorder;Oral;Oxycodone;oxycodone self-administration;Pathology;Pathway interactions;Pattern;Persons;Pharmaceutical Preparations;Phase;Phenotype;Predisposition;Process;Proteins;Proteomics;psychostimulant;Rattus;Reporting;Risk;RNA Sequences;Sampling;Self Administration;Signal Pathway;Techniques;Therapeutic;Tissues;tool;transcriptome sequencing;Variant;Viral;Work

PROJECT_TITLE: Genomic mechanisms of decision-making and opioid use trajectories in the rat


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Back Pain;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Dissemination and Implementation Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pain Research

ORG_DEPT: EMERGENCY MEDICINE

PHR: Project Narrative Low back pain affects 7-10% of the global population, is the leading cause of disability worldwide, and carries significant direct and indirect costs. Recent initiatives have focused on improving the quality of low back pain care being delivered, but challenges often remain to measure this in the clinical encounter. The proposed research will quantify and promote the use of patient reported outcome measures as one element of high- quality low back pain care by chiropractors through a clinical decision support tool while establishing a foundation for future study assessing effect on clinical outcomes.

PI_NAMEs: COLEMAN, BRIAN CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: MURRAY, PETER DANIEL

PROJECT_TERMS: acceptability and feasibility;Adoption;Affect;arm;Award;care delivery;career;Caring;Chiropractor;chiropracty;Clinic;Clinical;clinical decision support;Clinical effectiveness;clinical encounter;clinical implementation;Clinical Informatics;clinical practice;Clinical Practice Guideline;Clinical Research;Communication;Communities;Complementary Health;Consultations;cost effectiveness;Data;data mining;Development;Diagnosis;Direct Costs;disability;Documentation;effectiveness evaluation;Electronic Health Record;Electronics;Elements;experience;Facilities and Administrative Costs;Foundations;Funding;Future;Goals;Guidelines;Health;Health Care Costs;Health Professional;Health Status;implementation science;improved;Integrated Health Care Systems;Integrative Medicine;Intervention;Investigation;K-Series Research Career Programs;Knowledge;Life;Low Back Pain;Measures;Medical Informatics;Mentors;Methodology;Methods;Modeling;Musculoskeletal Pain;Natural Language Processing;Nonpharmacologic Therapy;Outcome;Outcome Measure;Pain;Pain intensity;Pain management;Pain Measurement;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Pattern;Perception;Pilot Projects;pilot test;point of care;Population;Pragmatic clinical trial;pragmatic trial;Prevalence;programs;Questionnaires;Recommendation;remediation;Research;Research Personnel;Sampling;Scientist;shared decision making;skills;Standardization;standardize measure;structured data;support tools;Surveys;System;Technology;technology intervention;Text;therapy development;Training;Translations;treatment planning;treatment trial;usability;Veterans Health Administration;Visit;week trial;Work

PROJECT_TITLE: Identifying and Promoting Quality Low Back Pain Care by Chiropractors


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Hepatitis;Human Genome;Immunotherapy;Liver Cancer;Liver Disease;Orphan Drug;Precision Medicine;Rare Diseases

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Hepatocellular carcinoma (HCC), the most common type of liver cancer, is a global public health problem. The goal of our proposal is to explore determinants of immunotherapy response in a subgroup of HCCs associated with non-alcoholic steatohepatitis (NASH) that are prone to immune evasion.

PI_NAMEs: LLOVET, JOSEP M (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Animal Model;anti-PD-1;anti-PD-L1;anti-PD1 therapy;antitumor effect;Architecture;Atlases;BAY 54-9085;bevacizumab;biomarker driven;biomarker identification;Biopsy;Cancer Etiology;candidate marker;CCL15 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cellular Structures;Clinic;Clinical;Clinical Trials;cohort;combinatorial;Coupled;CTNNB1 gene;Cultured Tumor Cells;Data;Diabetes Mellitus;drug testing;Etiology;Exclusion;experience;Fresh Tissue;gain of function mutation;Generations;Genes;genetic signature;Genomics;Goals;Hepatocarcinogenesis;Heterogeneity;Histologic;Human;Immune;Immune checkpoint inhibitor;Immune Evasion;immune resistance;Immune response;Immunologic Surveillance;Immunology;Immunooncology;Immunotherapeutic agent;Immunotherapy;Impairment;Incidence;individualized medicine;inhibitor;insight;Knowledge;Malignant neoplasm of liver;Malignant Neoplasms;MAP Kinase Gene;Maps;matrigel;Mitogen-Activated Protein Kinase Inhibitor;Molecular;molecular marker;mortality;mouse model;Mus;Mutation;neoplastic cell;neutrophil;nonalcoholic steatohepatitis;Obesity;objective response rate;Organoids;Outcome;Pathway interactions;patient stratification;Patients;Pharmaceutical Preparations;Population;Positioning Attribute;predicting response;preservation;Prevalence;Primary carcinoma of the liver cells;Probability;programmed cell death protein 1;prospective;Public Health;reconstitution;Refractory;Regulatory T-Lymphocyte;Reproducibility;Resistance;resistance mechanism;Resolution;response;response biomarker;Sampling;single cell technology;single-cell RNA sequencing;standard of care;Subgroup;synergism;Systemic Therapy;T-Cell Activation;T-Lymphocyte;Technology;Testing;Therapeutic;Therapeutic Uses;three dimensional cell culture;Tissues;tool;transcriptomics;treatment strategy;tumor;tumor microenvironment;Tumor-Infiltrating Lymphocytes;VEGFA gene;Viral;WNT Signaling Pathway

PROJECT_TITLE: Determinants of immunotherapy response in NASH-Hepatocellular carcinoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIO-D(01)Q]


ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Project Narrative The CRIC study is designed to study the reasons why kidney disease progresses over time, and to identify factors that contribute to development of heart disease. Over the last 20 years, this study has established an impressive infrastructure; we now propose to extend this study for another 3-year period to obtain additional information about kidney and heart conditions. This will help advance our understanding of kidney disease, and how it influences heart disease.

PI_NAMEs: RAHMAN, MAHBOOB  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Adult;Affect;American;Ancillary Study;Arrhythmia;Biological;Cardiovascular Diseases;Cardiovascular Manifestation;Cardiovascular system;care costs;Chronic Kidney Failure;Chronic Kidney Insufficiency;Chronic Phase;Clinical;clinical center;Clinical Research;cohort;Cohort Studies;Collaborations;Communities;comorbidity;Data;Data Collection;Data Coordinating Center;data integration;Data Sources;design;Development;disability;Disease Progression;Eligibility Determination;End stage renal failure;Enrollment;Ensure;Epidemiology;epidemiology study;ethnic diversity;Event;Evolution;follow-up;Funding;Future;Goals;health data;Heart;Heart Diseases;Heterogeneity;Home;home test;Individual;Infrastructure;innovation;Institution;Investigation;Kidney;Kidney Diseases;Kidney Function Tests;Laboratory Research;Link;Measurement;Measures;National Institute of Diabetes and Digestive and Kidney Diseases;nephrogenesis;novel;Observational epidemiology;Outcome;Output;Parents;Participant;participant enrollment;participant retention;Pathway interactions;Patient-Focused Outcomes;Phase;Phenotype;phenotypic data;Physiological;Positioning Attribute;Premature Mortality;Process;Productivity;programs;progression risk;Prospective cohort;Prospective Studies;Prospective, cohort study;Protocols documentation;Publications;racial diversity;recruit;renal damage;Renal function;repository;Research;Research Personnel;Resources;Risk Factors;Site;social;Source;Time;tool;Translational Research;Universities;Visit;Work

PROJECT_TITLE: Chronic Renal Insufficiency Cohort Limited competition continuation


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Back Pain;Bioengineering;Biomedical Imaging;Chronic Pain;Clinical Research;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Rehabilitation

ORG_CITY: SALT LAKE CITY

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative The proposed research is relevant to public health because chronic low back pain affects almost 1/3 of American adults and is estimated to cost $30 billion in direct health care expenditures and $100 to $200 billion in decreased wages and disability in the United States annually. Many of the currently available low back pain treatments are invasive with associated risks and complications. Magnetic resonance guided focused ultrasound, a novel, completely noninvasive technique, can precisely target spinal dorsal root ganglion to help ameliorate low back pain, potentially transforming the current practices.

PI_NAMEs: RIEKE, VIOLA  (contact);SHAH, LUBDHA

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: abuse liability;Acoustics;Acute;Address;Adult;Affect;American;Analgesics;Animal Model;Attenuated;Back Pain;Behavior assessment;behavior test;Behavioral;Biomechanics;Brain;Categories;Chronic;Chronic low back pain;chronic pain management;Clinical;clinical practice;clinical translation;Clinical Trials;cost;Data;design and construction;Development;Devices;Diagnosis;Diagnostic;disability;Disabling;effective therapy;Electroencephalography;Electrophysiology (science);Failure;Family suidae;Fiber;first-in-human;Focused Ultrasound;Funding;Goals;Health Expenditures;Hematoma;high resolution imaging;Human;Human Volunteers;Image;image guided;Implant;in vivo;Infection;Inflammatory;innovative technologies;Interruption;Intervention;Life;Low Back Pain;Magnetic Resonance;Magnetic Resonance Imaging;Measurable;Measures;Methodology;Methods;Mission;Modality;Modeling;Monitor;Muscle;Nerve;Neural Conduction;Neuritis;neuroinflammation;Neurons;Neuropathy;neurophysiology;neuroregulation;Neurostimulation procedures of spinal cord tissue;Nociception;non-invasive system;novel;Operative Surgical Procedures;Opioid;Outcome;Pain;Pain management;pain patient;pain perception;pain sensation;Patients;Peripheral nerve injury;Peripheral Nerve Stimulation;Persistent pain;Phase;Physiologic pulse;porcine model;Positioning Attribute;pre-clinical;Prevalence;Procedures;Process;programs;prototype;Public Health;Radiation exposure;radiation risk;radio frequency;Radiofrequency Interstitial Ablation;Research;response;Risk;Safety;Sensory;sensory cortex;Signal Transduction;simulation;Site;somatosensory;Somatosensory Evoked Potentials;Sonication;Source;Specificity;Spinal;Spinal Ganglia;Spine pain;Stimulus;Supratentorial;System;Techniques;Technology;technology research and development;Testing;Time;Tissues;Toxic effect;Transducers;Translating;translation to humans;Translations;Ultrasonic Transducer;United States;United States National Institutes of Health;Vertebral column;Wages

PROJECT_TITLE: Focused Ultrasound Neuromodulation of Dorsal Root Ganglion for Noninvasive Mitigation of Low Back Pain


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Obesity;Prevention

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Over half of American adults have overweight or obesity and are at high risk of developing type 2 diabetes and cardiovascular diseases. Although caloric restriction has many health benefits, it is difficult to sustain overtime for most people. Time restricted eating (TRE), a novel type of intermittent fasting, facilitates adherence to the intervention and results in weight loss and improvement of metabolism. We propose to test the effect of an intervention aiming to restrict the eating window to 10 hours/day, compared to habitual prolonged eating duration of >14hours/day, delivered via a smartphone application, on weight loss and metabolism, in metabolically unhealthy adults aged 50 to 70 y old, with overweight or obesity. We hypothesize that TRE, compared to habitual long duration of eating, will decrease cardiovascular risk burden.

PI_NAMEs: LAFERRERE, BLANDINE B (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: actigraphy;Adherence;Adult;aged;American;Award;behavior change;Binding;Blood Glucose;Body Weight;Body Weight decreased;Caloric Restriction;Calories;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cause of Death;Chronic;Chronic Disease;Consumption;Continuous Glucose Monitor;Controlled Study;Data;Diagnosis;doubly-labeled water;Eating;Effectiveness;efficacy evaluation;efficacy study;efficacy testing;energy balance;Energy Intake;Energy Metabolism;Event;Fasting;Fatty acid glycerol esters;follow-up;food restriction;Glucose;glucose metabolism;Goals;Health;Health Benefit;Health Technology;High Prevalence;high risk;Hour;Human;Hyperphagia;improved;improvement on sleep;Individual;Inpatients;insight;Insulin Resistance;insulin sensitivity;Intake;Intermittent fasting;Intervention;intervention effect;Life Style;lifestyle intervention;Lipid Mobilization;Magnetic Resonance;Measures;Mediating;Mediator;meetings;Metabolic;Metabolism;Methods;mHealth;middle age;Modeling;Monitor;Mus;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;Nonpharmacologic Therapy;novel;Obesity;older adult;Overweight;oxidation;Oxidative Stress;Participant;Pathway interactions;Pattern;Persons;Physical activity;Physiological;Pilot Projects;Prediabetes syndrome;Predisposition;prevent;Randomized;Randomized, Controlled Trials;reduced food intake;respiratory;Self Efficacy;Sleep;smartphone application;systemic inflammatory response;Testing;time use;Time-restricted feeding;weight maintenance

PROJECT_TITLE: TREAT (Time Restricted EATing) to improve cardiometabolic health

STUDY_SECTION: CIDO

STUDY_SECTION_NAME: Clinical and Integrative Diabetes and Obesity Study Section[CIDO]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: MADISON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Eukaryotes sense nutrients via the TARGET OF RAPAMYCIN (TOR) signaling hub to coordinate healthy growth and development; because of its central role in biology, dysregulation of TOR signaling causes or contributes to a broad range of human diseases, including cancers, age-related health decline, and metabolic disorders. Developing focused therapeutics that target disease-causing TOR signaling pathways without hampering healthy TOR-dependent growth and development will require a deep mechanistic and evolutionary understanding of the TOR signaling network. This project will take an innovative approach by elucidating how TOR senses amino acids in plant cells through an aminoacyl tRNA synthetase, illuminating how tRNA synthetases gain noncanonical roles in cells and contributing fresh perspective to ongoing debates about the relative roles and contributions of proposed mammalian amino acid sensors for TOR.

PI_NAMEs: BRUNKARD, JACOB O (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Affinity Chromatography;age related;Amino Acids;Amino Acyl-tRNA Synthetases;Arabidopsis;Binding;Biochemical;Biological Assay;Biological Models;Biology;Biomedical Research;Catalysis;Cells;Complex;Cues;detection of nutrient;Development;Disease;EIF-2alpha;Eukaryota;Evolution;experimental study;Foundations;Future;Genetic;genetic approach;Genomics;Goals;Growth;Growth and Development function;Health;Heart;Homeostasis;Human;human disease;improved;In Vitro;in vivo;innovation;Investigation;Knowledge;Label;Leucine;leucine-tRNA;life span;Malignant Neoplasms;Maps;Mediating;Mediation;Metabolic;Metabolic Diseases;Metabolism;metabolomics;Methodology;Methods;Modeling;Molecular;Morbidity - disease rate;mortality;mRNA Translation;Mutate;Mutation;Nitrogen;novel;Nutrient availability;Outcome;Pathway interactions;Phosphotransferases;Physiological;Physiology;Phytonutrients;Plants;Protein Kinase;protein protein interaction;Proteins;Proteomics;Regulation;Reporting;Reproducibility;Role;sensor;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Sirolimus;Solid;System;targeted treatment;Techniques;Testing;Therapeutic;therapeutic target;Transfer RNA;Translations;United States;Variant;Work;yeast two hybrid system

PROJECT_TITLE: A tRNA synthetase is an amino acid sensor for TOR in plants

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ADMINISTERING_IC: MH

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Clinical Research;HIV/AIDS;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative HIV associated neurocognitive disorders (HAND), a highly burdensome comorbid condition of HIV infection, continues to plague people with HIV (PWH) even in the current antiretroviral therapy (ART) era. Efforts to treat HAND are hindered by an incomplete understanding of the factors underlying its development. This proposal will examine the impact of a common antiretroviral regimen on autophagy, an essential process for homeostasis in astrocytes, the major support cells of the brain, as a pathogenic contribution to HAND to identify potential therapeutic targets for HAND.

PI_NAMEs: CHENEY, LAURA  (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Anti-Retroviral Agents;antiretroviral therapy;Astrocytes;Autophagocytosis;Autopsy;Brain;brain cell;brain tissue;career development;Cell Physiology;cell type;Cells;Clinical;college;Communicable Diseases;comorbidity;Confocal Microscopy;CRISPR/Cas technology;Data;Development;Employment;emtricitabine;Enzyme-Linked Immunosorbent Assay;experience;experimental study;Exposure to;extracellular;Flow Cytometry;Foundations;Functional disorder;Genus Hippocampus;Glutamates;Goals;HIV;HIV Infections;HIV-associated neurocognitive disorder;Homeostasis;Human;Immunofluorescence Immunologic;inhibition of autophagy;innovation;instructor;knock-down;Learning;light microscopy;Measures;Mediating;Medical center;Medicine;Membrane Potentials;Mentors;Microscopy;Mitochondria;mitochondrial autophagy;Modeling;mortality;neuroAIDS;Neurodegenerative Disorders;Neuropathogenesis;normal aging;novel;overexpression;Pathogenesis;Pathogenicity;Pathology;Persons;Pharmaceutical Preparations;pharmacologic;prevent;Principal Investigator;Process;Production;Program Development;Proteins;Proteolysis;Proteomics;Publishing;Quality Control;Quality of life;Quantitative Reverse Transcriptase PCR;receptor;Regimen;Reporter;Research;Respiration;response;RNA;Role;skills;Specificity;Stimulus;Supporting Cell;Techniques;Tenofovir;therapeutic target;therapy development;tool;Toxic effect;Transmission Electron Microscopy;uptake;Viremia;Western Blotting;Work

PROJECT_TITLE: Antiretroviral Therapy Impacts Autophagy in Astrocytes, and May Contribute to HIV Associated Neurocognitive Disorders

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Neurosciences;Nutrition;Obesity;Prevention;Substance Misuse

PHR: PROJECT NARRATIVE Bariatric surgery is the most effective treatment for severe obesity but it confers elevated risk for increased alcohol intake and alcohol use disorder (AUD) following surgery. The brain mechanisms underlying decreased high calorie food intake and increased alcohol intake after bariatric surgery remain largely unexplored. To address these gaps in knowledge, we will examine changes in neural responses to food and alcohol cues as well as blood alcohol concentrations (BAC) to an alcohol challenge from presurgery to 1 and 2 years (when alcohol intake increases) after surgery.

PI_NAMEs: GELIEBTER, ALLAN  (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: absorption;Address;Age;Alcohol consumption;alcohol cue;alcohol response;alcohol use disorder;Alcohols;Amygdaloid structure;Anatomy;Anterior;Area;Back;bariatric surgery;Blood alcohol level measurement;Body mass index;Body Weight;Body Weight decreased;Brain;Calories;cingulate cortex;Clinical;Clinical Trials;comorbidity;cue reactivity;Cues;Development;drinking;Drug Kinetics;Eating;effective therapy;Enrollment;Exhibits;Food;Frontal gyrus;Functional Magnetic Resonance Imaging;Gas Chromatography;Gastrectomy;Gastric Bypass;Incidence;Inferior frontal gyrus;Insula of Reil;Intake;Interview;Knowledge;Lead;Link;Matched Group;Measures;Medial;Modeling;Morbid Obesity;neural;neurobiological mechanism;Neurobiology;neuroimaging;neuromechanism;new therapeutic target;Operative Surgical Procedures;Outcome Measure;Pathway interactions;Precentral gyrus;prevent;primary outcome;Procedures;Research;response;Rewards;Risk;sex;Source;Symptoms;Testing;Time;timeline;Venous blood sampling;Ventral Striatum;Visual

PROJECT_TITLE: Neuroimaging to investigate mechanisms underlying changes in Intake of high energy dense foods and alcohol from pre to post bariatric surgery

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE (PUBLIC HEALTH RELEVANCE) Asthma is a common disease that has major impacts on human health, health care costs, and economic well- being. Airway passages are lined by a protective mucus barrier that becomes detrimental in asthma, resulting in impaired mucociliary clearance and disrupted breathing. Our research focuses on how specific proteins – MUC5AC and MUC5B – affect the functions of airway mucus in health and disease.

PI_NAMEs: EVANS, CHRISTOPHER M (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Affect;airway hyperresponsiveness;airway obstruction;Anabolism;Animal Model;Asthma;asthma model;Award;Biology;Breathing;Cell model;Cells;Chronic Obstructive Pulmonary Disease;Clinical;Cysteine;Data;Dimerization;Disease;disulfide bond;Disulfides;Economics;Endoplasmic Reticulum;Environment;experience;Exposure to;Functional disorder;Future;Golgi Apparatus;Health;Health Care Costs;Hemostatic function;Histidine;Homeostasis;Host Defense;Human;Impairment;improved;Intervention;Intestines;Knockout Mice;Lung;Lung Diseases;macromolecule;Mediating;member;Muc 2 protein;MUC5AC gene;MUC5B gene;Mucins;Mucociliary Clearance;Mucous body substance;Mus;N-terminal;novel;particle;Pathologic;Personal Satisfaction;Physiological;polymerization;Polymers;Positioning Attribute;Post-Translational Protein Processing;preservation;prevent;Process;Property;Protein Isoforms;Proteins;public health relevance;Pulmonary Fibrosis;Research;Role;Shapes;Testing;Therapeutic Intervention;Thinness;Translations;treatment strategy;Up-Regulation;von Willebrand Factor

PROJECT_TITLE: Role of mucin in lung homeostasis and pathophysiology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RCCS-B(03)]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Estrogen;Genetics;Precision Medicine;Rare Diseases;Scleroderma;Women's Health Research;Wound Healing and Care

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative Systemic sclerosis is a rare autoimmune disease that leads to widespread fibrosis and death. Although rare, having a better understanding of systemic sclerosis may be helpful in more prevalent diseases where fibrosis also occurs and accounts for up to 45% of deaths. Because women are more often diagnosed with systemic sclerosis and have more estrogen, the goal of this project is to discover if estrogen encourages skin fibrosis in systemic sclerosis, so that medications that block estrogen may be used to treat fibrosis.

PI_NAMEs: BAKER FROST, DEANNA  (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Advisory Committees;Affect;African American;African American population;Age;Aromatase Inhibitors;Autoantibodies;Autoimmune Diseases;Basic Science;Bioinformatics;Biological Markers;Biology;career;career development;Caucasians;Cessation of life;Characteristics;Clinical;clinical center;Clinical Research;cohort;Cost of Illness;Cutaneous;Data Analyses;Dehydroepiandrosterone Sulfate;Dermal;Diagnosis;Diffuse;Diffuse Scleroderma;Direct Costs;disability;Disease;Disease Outcome;Disproportionately impacts women;ESR1 gene;Estradiol;Estradiol Receptors;Estrogen Receptors;Estrogens;ethnic diversity;experience;Extracellular Matrix;Facilities and Administrative Costs;FDA approved;Female;Fibroblasts;Fibronectins;Fibrosis;Fostering;Foundations;Fulvestrant;Gender;Gene Expression;Gene Expression Profile;General Population;Genetic Transcription;Genomics;Goals;Gonadal Steroid Hormones;Hormonal;Human;In Vitro;in vivo;innovation;Knock-out;Knockout Mice;male;Measures;Mediator;Mentors;Modeling;Morbidity - disease rate;mortality;mouse model;mRNA sequencing;Mus;new therapeutic target;non-genomic;novel;Outcome;Pathogenesis;Patients;personalized medicine;Pharmaceutical Preparations;Postmenopause;potential biomarker;prevent;Production;Profibrotic signal;Prognosis;Protein Isoforms;Receptor Signaling;Research;Research Institute;Research Support;Resources;Rheumatology;Role;Serum;Severities;Severity of illness;sex;Signal Transduction;Skin;skin fibrosis;Skin Tissue;South Carolina;supportive environment;Systemic Scleroderma;targeted treatment;Testing;Testosterone;Time;time interval;Tissue-Specific Gene Expression;Training;transcriptomics;Transforming Growth Factor beta;Transforming Growth Factor Beta 2;Translational Research;Woman

PROJECT_TITLE: The Role of Hormonal Dysregulation in Systemic Sclerosis

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: PROJECT NARRATIVE Most people living with dementia (PLWD) prefer to remain at home in the community, yet research shows that they are less likely than people without dementia to successfully return to the community following nursing facility stays. This mixed methods study analyzes how different factors are driving disparities for PLWD and what potential policy solutions could improve health equity for PLWD, through in-depth interviews with individuals eligible for the Money Follows the Person (MFP) program and their informal caregivers, focus groups and surveys with professionals involved in the MFP program, and statistical analysis of a large group of Connecticut Medicaid nursing facility residents. Our team has a long-standing partnership with Connecticut's Department of Social Services (the state Medicaid administrator) which is enthusiastic about using our findings to reduce disparities in MFP outcomes for this population.

PI_NAMEs: DILLON, ELLIS C (contact);ROBISON, JULIE THOMPSON

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: access disparities;Address;Administrator;Age;aging in place;Alzheimer's Disease;Alzheimer's disease related dementia;Automobile Driving;Back;Behavioral Symptoms;Belief;Black Populations;Black race;Caregiver support;Caregivers;cohort;Communities;community based service;community living;community setting;community-level factor;Connecticut;COVID-19 pandemic;Data;Data Set;Data Sources;Deinstitutionalization;Dementia;Development;Disabled Persons;Discipline of Nursing;Disparity;disparity reduction;Economics;Eligibility Determination;Equity;Ethnic Origin;Ethnic Population;experience;Familiarity;Family;Family member;family support;Focus Groups;Government;Health;health difference;health equity;Health Status;Hispanic;Home;improved;Individual;informal caregiver;innovation;Interview;Leadership;Medicaid;Medicare claim;Medicare/Medicaid;Methods;Modeling;Not Hispanic or Latino;older adult;Older Population;Outcome;Participant;Persons;Policies;Politics;Population;preference;pressure;Process;Professional Practice;programs;racial difference;racial population;recruit;Research;Sampling;service providers;Social Work;Statistical Data Interpretation;Structure;success;Surveys

PROJECT_TITLE: Increasing successful returns to community living from nursing facilities through the Money Follows the Person program: Mechanisms for reducing disparities for older adults with dementia


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE The COVID-19 pandemic has disproportionately negatively impacted families that experience other intersecting forms of socioeconomic disadvantage and inequity. One key, and potentially modifiable, protective pathway to supporting youth resilience during and beyond the COVID-19 pandemic is physical activity. This project would inform efforts on how to best support schools in low resource communities in increasing physical activity opportunities, with a particular emphasis on meeting the physical activity-related needs of youth who have experienced Adverse Childhood Experiences (ACEs) and trauma related to COVID-19 or otherwise.

PI_NAMEs: KROSHUS, EMILY GRACE;TANDON, POOJA SARIN (contact)

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: Acceleration;Accelerometer;acceptability and feasibility;Address;Adopted;adverse childhood events;Age;anxiety symptoms;Black race;Cessation of life;Child;childhood adversity;children of color;community engagement;County;COVID-19;COVID-19 pandemic;Data;depressive symptoms;design;disadvantaged student;effectiveness/implementation trial;Equity;Ethnic Origin;evidence base;exercise intervention;experience;Exposure to;Family;Family member;feasibility testing;fitness;Gender;Goals;Guidelines;Health;healthy weight;Hispanic;Hybrids;immune function;improved;Indigenous;Inequity;Informal Social Control;Intervention;intervention effect;intervention program;junior high school;literacy;Low income;Maintenance;Measures;meetings;Mental Health;Methods;moderate-to-vigorous physical activity;Monitor;Outcome;pandemic disease;peer;people of color;Personal Satisfaction;Phase;Physical activity;physical conditioning;Physical Education;Physical Fitness;pilot test;Play;Population;Poverty;programs;protective pathway;psychosocial;Race;Recommendation;reduce symptoms;Reporting;Research Design;resilience;Resource-limited setting;Resources;response;Risk;school district;Schools;Secondary Schools;sedentary;Self Concept;socioeconomic disadvantage;Socioeconomic Status;Strategic Planning;stressor;Students;Symptoms;System;system-level barriers;teacher;Teacher Professional Development;Time;Training;Trauma;uptake;Vulnerable Populations;Youth

PROJECT_TITLE: Trauma-adapted Comprehensive School Physical Activity Program (CSPAP)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-H(58)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Giardia is the causative agent of giardiasis, a prevalent gastrointestinal illness that results in diarrhea and malabsorption in more than 200 million people each year. This proposal investigates the role of EncystR, a receptor regulating encystation, and its connection to downstream cAMP signaling in the regulation of Giardia cysts formation. Encystation requires parasite detachment from the host intestine; therefore, misregulation of the receptor and downstream signaling could be exploited to clear infection.

PI_NAMEs: PAREDEZ, ALEXANDER RICHARD (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Amino Acid Transporter;Amino Acids;Awareness;Biology;Biosensor;Cell Cycle Arrest;Cell membrane;Cells;Cellular Assay;Cellular biology;Cessation of life;Cholesterol;Citrulline;Clinical Treatment;clinically relevant;Complement;Complex;Cues;Cyclic AMP;Cyst;Cytoskeleton;Data;Defect;design;Detection;detection of nutrient;Development;Developmental Biology;Diarrhea;drug action;Effectiveness;Energy-Generating Resources;Environment;Exposure to;Family;Foundations;Free Radicals;G-Protein-Coupled Receptors;gain of function;gastrointestinal;Gastrointestinal Diseases;Generations;genetic analysis;Genetic Transcription;Giardia;Giardia lamblia;Giardiasis;Goals;Growth;Guanosine Triphosphate Phosphohydrolases;gut colonization;Homologous Gene;Image;improved;Incidence;Infection;insight;interest;Intervention;Intestines;knock-down;Knowledge;Life Cycle Stages;loss of function;Malabsorption Syndromes;Mastigophora;Membrane;Membrane Proteins;Metabolic;Molecular;Molecular Conformation;Mutate;Names;nanoluciferase;novel;Nutrient;Opsin;Oral;overexpression;Parasites;Pathway interactions;Perception;Persons;Pharmaceutical Preparations;phosphoproteomics;Phosphotransferases;prevent;Process;Production;programs;Proliferating;protein protein interaction;Proteins;public health relevance;receptor;Regulation;Reporting;Resistance;response;rho;rho GTP-Binding Proteins;Risk;Role;sensor;Shapes;side effect;Signal Transduction;spatiotemporal;Starvation;Stimulus;Testing;therapeutic development;trafficking;Translating;transmission process;treatment strategy;uptake;Work

PROJECT_TITLE: Signal perception and transduction regulating Giardia cyst formation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-R(02)]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: NARRATIVE We have identified a new mutation in a protein that causes heart rhythm problems, heart function problems, and autism in mostly in boys. This protein modifies or changes the function of many other proteins in the body as soon as they are made. This modifying protein may be involved in causing abnormal heart rhythms in patients with heart failure and studying its function will improve how we treat patients with similar problems.

PI_NAMEs: BEZZERIDES, VASSILIOS JAMES (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: Ablation;Acetylation;Acetyltransferase;Action Potentials;Affect;Animal Model;Arrhythmia;autism spectrum disorder;Biological Models;boys;Calcium;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiovascular Diseases;Catalytic Domain;Characteristics;clinical phenotype;Complex;congenital heart abnormality;Data;Developmental Delay Disorders;Dilated Cardiomyopathy;Disease;Electrophysiology (science);Family;Family member;Fibrosis;Functional disorder;genetic pedigree;Genetic Predisposition to Disease;Heart;Heart Abnormalities;Heart Diseases;Heart failure;heart function;heart rhythm;Homeostasis;Human;Impairment;improved;Individual;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;insight;Ion Channel;Ions;kindred;Knockout Mice;Learning Disabilities;male;Mediating;Modeling;Modification;Morbidity - disease rate;mortality;mouse model;Mutation;Myocardial;Myocardial dysfunction;N-terminal;novel;overexpression;Patients;Phenotype;Physiological;Post-Translational Protein Processing;Potassium;Potassium Channel;pressure;protein complex;Proteins;Proteome;Proteomics;Recurrence;Risk;risk stratification;Role;Sodium;Sodium Channel;stem cell model;Structure;Sudden Death;Testing;therapeutic development;Ventricular Arrhythmia;Ventricular Dysfunction;women patients

PROJECT_TITLE: The role N-terminal acetylation in dilated cardiomyopathy and associated arrhythmia

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Prevention;Schizophrenia;Serious Mental Illness

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Schizophrenia is a highly heritable neuropsychiatric disorder for which diagnostic and treatment options are limited. Advances in genetics have started to reveal pathways underlying the disorder, including synaptic biology and enzymes of glycosylation. In this study, I will investigate synaptic alterations caused by the schizophrenia-associated missense variant in SLC39A8, providing mechanistic insights to pathophysiology with clear potential for developing of novel therapeutics.

PI_NAMEs: MEALER, ROBERT G (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: adhesion receptor;Adolescence;Advisory Committees;Affect;Award;Biological;Biology;Brain;Brain Diseases;Carbohydrates;career;Cell Adhesion Molecules;Cell-Adhesion Molecule Receptors;Chromosome Pairing;Clinical Trials;Code;cofactor;Complement;Complex;confocal imaging;Consultations;critical period;Data;Dendritic Spines;density;Deposition;Development;Diagnostic;Disease;Dopamine;Environment;Enzymes;experience;experimental study;Family;Follow-Up Studies;Fostering;frontal lobe;Functional disorder;Future;gamma-Aminobutyric Acid;Genes;Genetic;genetic association;Genetic Risk;Genetically Engineered Mouse;Genome;genome wide association study;Glutamate Receptor;Glycobiology;Glycoproteins;glycoproteomics;glycosylation;Goals;Heritability;Homeostasis;Human;Impairment;improved;Individual;insight;Instruction;Jordan;K-Series Research Career Programs;Knock-in Mouse;Laboratories;Length;Link;Lipids;Manganese;Maps;member;Membrane;Mendelian disorder;Mentorship;Metals;Methods;Missense Mutation;Molecular;Molecular Analysis;mouse model;Mus;Mutation;neurodevelopment;Neurologic;Neurons;neuropsychiatric disorder;Neurosciences;neurotransmission;Neurotransmitter Receptor;novel;novel therapeutics;Oral;Pathogenesis;Pathway interactions;Peripheral;Phenotype;Plasma;Play;Polysaccharides;post-doctoral training;pre-clinical;preclinical safety;Productivity;Protein Glycosylation;Proteins;Proteomics;Psychiatry;psychogenetics;Psychopharmacology;Qualifying;receptor;Research;Research Personnel;Residencies;risk variant;Rodent;Role;Schizophrenia;schizophrenia risk;severe mental illness;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Supplementation;Synapses;synaptic function;synaptic pruning;Techniques;Testing;Therapeutic;Trace Elements;trafficking;Training;Translating;translational study;Translations;trial design;Untranslated RNA;Variant;Work

PROJECT_TITLE: Synaptic dysglycosylation caused by the schizophrenia-risk variant in SLC39A8


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Disease;Precision Medicine

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because identifying the molecular mechanisms by which ceramide inactivates human hepatic stellate cells and ameliorates fibrosis will enhance our understanding of fibrogenesis and improve our ability to halt disease progression among patients with chronic liver disease. Thus, the proposed project is relevant to the NIH’s mission to seek and apply knowledge to lengthen life and reduce illness.

PI_NAMEs: CHEN, JENNIFER Y. (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Ablation;Affect;American;antifibrotic treatment;Atomic Force Microscopy;attenuation;Biochemical;Biological Assay;Biological Markers;Cells;Ceramide Signaling Pathway;Ceramides;Cessation of life;Characteristics;Chronic;chronic liver disease;Clinical;clinical diagnostics;Clinical Treatment;clinically relevant;cohort;Collagen;conditional knockout;Data;Deposition;Development;Diagnosis;Diagnostic tests;Disease;disease heterogeneity;Disease Progression;effective therapy;end stage liver disease;Enzymes;Extracellular Matrix;Extracellular Matrix Degradation;FDA approved;fibrogenesis;Fibrosis;gain of function;galactosylgalactosylglucosylceramidase;Genes;genetic signature;Goals;Hepatic Fibrogenesis;Hepatic Stellate Cell;Human;Hydrolysis;improved;In Vitro;in vivo;Interstitial Collagenase;Knockout Mice;Knowledge;Life;Liver;Liver Failure;Liver Fibrosis;loss of function;Matrix Metalloproteinases;Mediating;Mediator;Mission;Modeling;Modification;Molecular;non-alcoholic fatty liver disease;novel therapeutics;Outcome;Pathway interactions;patient biomarkers;patient population;patient subsets;Patients;personalized medicine;Play;prevent;Public Health;Publishing;Regulation;Research;Resolution;response;Role;Sampling;Severities;side effect;Signal Pathway;Signal Transduction;specific biomarkers;STK11 gene;Stress;Techniques;Testing;Therapeutic;United States National Institutes of Health;Work

PROJECT_TITLE: Dissecting the Acid Ceramidase Pathway in Hepatic Fibrogenesis

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Obesity;Pediatric

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative Type 2 diabetes (T2D), once considered only “a disease of older ages,” is now a significant public health concern in children. Although it is characterized by insulin resistance and impaired insulin secretion, its precise etiology and pathogenesis are not yet fully understood. This study aims to (1) explore arginine metabolism in pediatric T2D via safe, minimally invasive kinetic experiments using stable isotope tracers and targeted metabolomics, and (2) determine the effect of exogenous arginine administration on β-cell function in children with T2D, potentially supporting use of this safe, low-cost, and readily available nutrient to improve pediatric diabetes outcomes.

PI_NAMEs: TOSUR, MUSTAFA  (contact)

PROGRAM_OFFICER_NAME: LINDER, BARBARA

PROJECT_TERMS: Acute;Address;Adult;Affect;Age;amino acid metabolism;arginase;Arginine;Beta Cell;Biometry;Bolus Infusion;cardiovascular disorder risk;career development;Cell membrane;Cell Physiology;Cells;Child;Childhood;Childhood diabetes;Citrulline;Clinical;Clinical Trials;Closure by clamp;college;comparison control;cost;Coupled;Data;Data Analyses;Defect;Development Plans;Diabetes Mellitus;Dietary intake;Disease;Etiology;experience;experimental study;Fasting;Funding;future implementation;Glutamine;glycemic control;Goals;Guanylate Cyclase;Health Care Costs;human old age (65+);Hyperglycemia;Impairment;improved;Incidence;Infusion procedures;Infusion Technique;Insulin;Insulin Resistance;insulin secretion;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;Intravenous;Investigation;Isotopes;K-Series Research Career Programs;Kinetics;Knowledge;Mass Spectrum Analysis;Mediating;Medicine;Membrane;Mentorship;Metabolic;Metabolic Pathway;Metabolism;metabolomics;minimally invasive;Molecular;Newly Diagnosed;Nitric Oxide;Nitric Oxide Synthase;Non-Insulin-Dependent Diabetes Mellitus;Nutrient availability;Obesity Epidemic;obesity in children;OGTT;Oral;Outcome;oxidation;Pathogenesis;Pathway interactions;patient population;Patients;Pediatric Hospitals;Plasma;Play;Population;Process;Production;Public Health;Research;Resources;response;Risk Factors;Role;stable isotope;Stimulant;Structure of beta Cell of islet;Supplementation;Techniques;Testing;Texas;tool;Tracer;Training;type 2 diabetes in children;Validation;Vulnerable Populations

PROJECT_TITLE: Investigation of Arginine Metabolism and Its Effects on Beta Cell Function in Children with Type 2 Diabetes

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK(M1)-1-B]


PHR: Project Narrative: According to the Centers for Disease Control, 9.6% of people in assisted living are anemic and anemia accounts for 1.5 deaths per 100,000 individuals. Causes of anemia stem from inappropriate iron acquisition and storage and/or the inability to make heme. The University of Utah Center for Iron and Heme Disorders will provide technology and training to study anemia as well as iron and heme metabolism disorders with the goal of identifying new causes and therapies to treat these disorders.

PI_NAMEs: BEAUDIN, ANNA E  (contact);COX, JAMES ERIC

PROGRAM_OFFICER_NAME: NORTON, JENNIFER MICHELLE

PROJECT_TERMS: Affect;Anemia;Area;Assisted Living Facilities;Award;base;Binding;Biochemical;Biochemistry;Biological;Biological Assay;Biological Process;Biomedical Research;Cell Respiration;Centers for Disease Control and Prevention (U.S.);Cessation of life;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;Collaborations;Copper;cost effective;Cultured Cells;design;Detection;Diamond-Blackfan anemia;Disease;DNA biosynthesis;Educational workshop;Enzymes;Equipment;Erythropoiesis;Faculty;Fees and Charges;Free Radicals;Funding;Gene Modified;Gene Mutation;Generations;Genes;genome editing;Globin;Goals;Hematology;Hematopoiesis;Heme;heme biosynthesis;Heme Group;Hemeproteins;Hemoglobin;Homeostasis;human disease;Human Genetics;Individual;Institution;interest;Interest Group;Iron;Iron Overload;Letters;Liquid substance;macromolecule;medical schools;Medicine;meetings;member;Mentors;Metabolic Diseases;Metabolic Pathway;Metabolism;Metabolite Interaction;metabolomics;metal metabolism;metal metabolism disorder;Metals;Methods;Molecular;Mononuclear;multidisciplinary;Mutation;National Institute of Diabetes and Digestive and Kidney Diseases;new technology;next generation;Non-Malignant;novel;operation;oxygen transport;Pathology;Persons;Phenotype;Pilot Projects;Play;Porphyrias;Porphyrins;Postdoctoral Fellow;pre-doctoral;programs;Progress Reports;protein metabolite;Proteins;Proteomics;Reagent;Recording of previous events;Research;Research Activity;Research Design;Research Personnel;Research Project Grants;Research Training;Resources;Role;Scientist;Series;Services;Source;stem;stem cell biology;Sulfur;symposium;synergism;Technology;Training;transcription activator-like effector nucleases;Transition Elements;Universities;Utah;Visit

PROJECT_TITLE: Center for Iron & Heme Disorders at the University of Utah


PI_NAMEs: PHILLIPS, JOHN DEARBORN (contact)

PROJECT_TERMS: Address;Advisory Committees;Award;Back;Budgets;Communication;Critiques;Disease;Electronics;Ensure;Event;Expenditure;Financial Support;Funding;Goals;Grant;Guidelines;Heme;Internet;Iron;meetings;member;Monitor;Names;National Institute of Diabetes and Digestive and Kidney Diseases;new technology;Office of Administrative Management;operation;organizational structure;Persons;Pilot Projects;Process;programs;Progress Reports;Protocols documentation;Research Personnel;Schedule;Seasons;Services;Structure;Textiles;United States National Institutes of Health;Universities;Utah;Voting;ward;web site;Work;working group

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Cocaine;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Methamphetamine;Opioid Misuse and Addiction;Opioids;Patient Safety;Prevention;Stimulant Use and Misuse;Substance Misuse

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: This study will estimate the prevalence and correlates of exposure to new psychoactive substances and other drugs and associated adverse effects among nightclub and dance festival attendees in New York City. Saliva testing will be conducted to determine unintentional drug exposure and to build effect profiles of new drugs that emerge. Results will be rapidly disseminated to inform prevention and harm reduction not only among this population but also in the general population.

PI_NAMEs: PALAMAR, JOSEPH J (contact)

PROGRAM_OFFICER_NAME: CREAMER, MELISA RAY

PROJECT_TERMS: Adult;Adverse drug effect;Adverse effects;adverse outcome;Attention;bath salts;Case Study;Cessation of life;Cocaine;cocaine exposure;cocaine use;Dancing;Diffuse;Drug Exposure;drug testing;Drug usage;ecstasy;Electronic Mail;Electronics;Enrollment;Epidemiology;epidemiology study;Event;Exposure to;Fentanyl;fentanyl analog;fentanyl exposure;Festival;follow-up;Future;General Population;Hair;Harm Reduction;Heroin;heroin use;high risk;high risk population;Hospitalization;Hospitals;impression;innovation;Ketamine;Methamphetamine;Methods;Mollies;Music;New York City;novel therapeutics;Opioid;Outcome;Overdose;Participant;Patient Self-Report;Persons;Pharmaceutical Preparations;Poisoning;Population;predictive test;Prevalence;prevent;Prevention;Probability Samples;recruit;Reporting;Research Personnel;Risk Factors;Saliva;saliva sample;salivary assay;Sampling;Schedule;Scientist;Secure;Seizures;Social Network;Specimen;Surveys;synthetic cannabinoid;Testing;Theoretical model;time use;Toxicology;trend;willingness;Work

PROJECT_TITLE: New psychoactive substance exposure among NYC nightclub and festival attendees

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


PI_NAMEs: JACKSON, LAURIE K (contact)

PROJECT_TERMS: Aminolevulinic Acid;Awareness;Bilirubin;Biliverdine;Biological;Biological Assay;Cells;Charge;Communities;Copper;coproporphyrinogen oxidase;Country;Disease;Education;enzyme activity;Enzymes;Experimental Designs;Feces;Fee-for-Service Plans;ferrochelatase;Health Services Accessibility;Hematology;Heme;heme a;heme biosynthesis;heme C;Human;Hydroxymethylbilane Synthase;Inductively Coupled Plasma Mass Spectrometry;Institution;Iron;Isomerism;Laboratories;learning strategy;Liquid substance;Manganese;Measurement;Measures;member;Metals;Methods;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Malignant;novel;Organelles;Pathway interactions;Persons;Porphobilinogen Synthase;Porphyrins;Progress Reports;Protocols documentation;protoporphyrin IX;Protoporphyrinogen oxidase;Quality Control;Research;Research Personnel;Resources;Sampling;Services;System;Time;tissue/cell culture;Tissues;Training;Universities;Urine;Uroporphyrinogen Decarboxylase;Uroporphyrins;Utah;Validation;web site;Whole Blood;Zinc;zinc-protoporphyrin-9

PROJECT_TITLE: Iron and Heme Core


NIH_SPENDING_CATS: Bioengineering

PI_NAMEs: COX, JAMES ERIC (contact)

PROJECT_TERMS: Address;base;Bioinformatics;bioinformatics tool;Biological Models;cell type;Cellular biology;Communication;Communities;Computer software;Custom;Data;Data Analyses;Data Reporting;Data Set;Development;Disease;Education;Educational workshop;Erythrocytes;Goals;Hematology;Hematopoiesis;Heme;Homeostasis;Human Resources;improved;Individual;instrument;instrumentation;Investigator-Initiated Research;Iron;Isotopes;lipidomics;Mass Spectrum Analysis;member;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methodology;Methods;online course;Output;Paper;Pathway interactions;Persons;Porphyrins;Postdoctoral Fellow;Preparation;Process;Productivity;Publishing;rapid test;Reporting;Research Personnel;Resolution;Resources;response;Sampling;Site;small molecule;social media;Software Tools;Standardization;Students;success;Techniques;Technology;tool;Tracer;training opportunity;trend;Universities;Utah;virtual

PROJECT_TITLE: Metabolomics Core


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_DEPT: SURGERY

PHR: Project Narrative  Permanent His bundle or left bundle branch (LBB) pacing reduces hemodynamic complications associated with standard right ventricular apical pacing. The efficacy of antitachycardia pacing with His bundle and LBB leads will be tested. A novel His bundle and LBB pacing lead with multiple electrodes to maximize selectivity, sensitivity, and low-threshold stimulation will be developed and tested. Improved antitachycardia pacing and improved His bundle and LBB leads could have an immediate positive impact on many of the one million patients worldwide that receive pacemaker implants each year.

PI_NAMEs: DOSDALL, DEREK J (contact)

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: Acute;Adoption;Apical;Arrhythmia;battery life;canine model;Canis familiaris;Cardiac pacemaker;Cardiomyopathies;Chronic;Clinical;Clinical Trials;Congestive Heart Failure;Development;Effectiveness;Electrodes;epicardial mapping;evidence base;Functional disorder;Funding;Goals;Heart;Heart failure;Heart Rate;hemodynamics;Implant;implantable device;implantation;improved;in vivo;Incidence;individual patient;individual response;Infarction;Ischemia;Lead;Learning;Left;Length;Maps;Modeling;mortality;Myocardial;Myocardium;neural;Nodal;novel;optimal treatments;Pacemakers;Pain;Patients;Performance;Physicians;Physiologic pulse;Physiological;Preparation;Reperfusion Therapy;Right ventricular structure;Role;Safety;Science;Shock;Sinus;Site;System;Tachycardia;Techniques;Testing;tool;trend;Validation;Venous;Ventricular;Ventricular Tachycardia;Work

PROJECT_TITLE: Antitachycardia pacing and improved lead for ventricular conduction system stimulation

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Immunotherapy;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Global access to vaccines, especially those that require multiple doses, is challenged by patient hesitancy and logistical hurdles that hinder equitable distribution. This project seeks to develop a new vaccine platform for sublingual vaccination based on the self-assembly of protein fragments. Shelf-stable, easily administered, and minimally reactogenic, the platform aims to provide an alternative to needle-based vaccines relying on continuous refrigeration.

PI_NAMEs: COLLIER, JOEL H (contact)

PROGRAM_OFFICER_NAME: MALASPINA, ANGELA

PROJECT_TERMS: Adhesives;Adjuvant;Affect;Allergic;Antibody Response;Antigens;Articulation;Attention;Autoimmune Diseases;B-Lymphocytes;Biocompatible Materials;Biomedical Engineering;Charge;Child;Cold Chains;Communicable Diseases;design;Disease;Distress;Dose;Engineering;Epitopes;Equity;ethnic minority;Experimental Designs;Face;global health;Glycoproteins;HIV-1;Human;Immune response;Immunization;immunoengineering;immunogenic;Immunologist;Immunotherapeutic agent;Immunotherapy;improved;Individual;Inequity;Inflammatory;Influenza;Injections;innovation;interest;Investigation;Lymphatic;Lymphoid Tissue;Malignant Neoplasms;minority communities;Modeling;Modification;Molecular;molecular assembly/self assembly;mouse model;Mucins;Mucous Membrane;Mus;Names;nanofiber;Needles;novel vaccines;Oral mucous membrane structure;Oryctolagus cuniculus;Pain;Pain Free;Patients;Penetration;peptide vaccination;Peptides;physical property;Polymers;prevent;Protein Fragment;Proteins;Public Health;racial minority;Refrigeration;Regimen;response;RNA vaccine;Route;Schools;self assembly;Shapes;Specialist;STING agonists;success;Surface;System;T-Lymphocyte Epitopes;Tablets;Technology;Temperature;Tongue;trafficking;Vaccination;vaccination strategy;vaccine access;vaccine distribution;vaccine hesitancy;vaccine platform;Vaccines;Work;World Health Organization;ZIKA

PROJECT_TITLE: Sublingual Supramolecular Vaccines and Immunotherapies

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]