ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative The proposed study will be the first study to use the theoretical framework of acceptability to create a tool (questionnaire) that assesses the acceptability of health-related social needs (HRSN) screening among Black patients receiving care at NYU Langone Health. With increased emphasis on patient-centered care in recent years in the US, there is growing interest in collecting information on patients’ clinical and social needs, providing unprecedented opportunities to identify socially disadvantaged individuals at increased risk of poor health outcomes. Examining the acceptability of HRSN screening tools will provide comprehensive information on the best approach for improving HRSN screening experiences for minoritized populations, with implications for shaping training of providers and staff in best practices for increasing acceptability, and inform recommendations for universal screening of HRSN.

PI_NAMEs: ONAKOMAIYA, DEBORAH  (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: Academy;Accountability;Active Learning;Address;Admission activity;Affective;Area;Attitude;black patient;Black Populations;Black race;burden of illness;Cardiovascular system;career;Caregivers;Caring;Chronic Disease;Clinical;Cognitive;Communities;Community Health;Development;Diabetes Mellitus;Dimensions;Disease Management;Disparity population;Effectiveness;Emotional;Ethics;ethnic minority;experience;Factor Analysis;Feeling;Food;food insecurity;food security;Goals;Health;health care settings;Health Disparities Research;health inequalities;Health Services;Health Services Research;Health system;Housing;housing instability;implementation science;improved;Infrastructure;insight;Integrated Health Care Systems;interest;Intervention;intimate partner violence;Joint Commission on Accreditation of Healthcare Organizations;Knowledge;Learning;Measures;Medicine;Mentors;Mentorship;Methods;Minority Groups;National Institute on Minority Health and Health Disparities;National Research Service Awards;New York City;opportunity cost;Outcome;Parents;patient population;patient screening;Patient-Centered Care;Patients;Persons;Physicians;poor health outcome;Population;Positioning Attribute;Preventive;Procedures;Provider;Psychometrics;Public Health Practice;Questionnaires;racial minority;Recommendation;Research;Research Design;Research Methodology;Research Training;Resources;response;Risk;Safety;Sampling;screening;Screening procedure;Self Efficacy;Shame;Shapes;Signal Transduction;social;social disparities;social health determinants;statistics;Stroke;Structural Racism;support tools;System;Testing;theories;tool;Training;Transportation;Trust;United States Centers for Medicare and Medicaid Services

PROJECT_TITLE: The Application of a Theoretical Framework to Assess the Acceptability of a Health-Related Social Needs Screening Tool Among Black Patients In New York City

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-E(20)L]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: WINSTON-SALEM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narrative Millions of individuals suffer from skeletal muscle atrophy and contractile dysfunction (i.e. muscle weakness), a hallmark of several physiological and pathological conditions, including sarcopenia and cachexia elicited by cancer. Despite the significance of myopathy on quality of life and healthspan, no pharmacological therapies are currently available to mitigate the loss of muscle mass and function. The experiments in this proposal will test the impact of unacylated ghrelin on skeletal muscle weakness in aging and cancer cachexia. Our research has a high chance of translation based on its excellent safety profiles in humans and no effects on cancer cell growth.

PI_NAMEs: AHN, BUMSOO  (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Actomyosin;Acute;Acylation;Adult;age related;Aging;Animals;Applied Skills;Atrophic;Attenuated;Binding;Biological Assay;Brain;Cachexia;Calcium;Cancer Cachexia;cancer cell;Cancer Cell Growth;Cancer Model;clinical candidate;Clinical Trials;clinically significant;Coculture Techniques;Colon Carcinoma;Colorectal Cancer;Cyclic AMP-Dependent Protein Kinases;cytokine;Data;Degenerative Disorder;Elderly;energy balance;experimental study;Fiber;FRAP1 gene;Functional disorder;Generations;ghrelin;GHS-R1a;Glucocorticoids;Goals;hallmarks of aging;healthspan;Hormones;Human;Impairment;improved;in vivo;increased appetite;Incubated;Individual;Inflammation;Inflammatory;innovation;Interferon Type II;Intervention;Laboratories;Lead;lean body mass;Lewis lung carcinoma cell;Malignant Epithelial Cell;Malignant Neoplasms;Measures;member;Microfilaments;Mitochondria;Modeling;Modification;Molecular;Molecular Biology;Mus;Muscle;muscle aging;Muscle denervation procedure;Muscle Fibers;muscle form;Muscle function;Muscle Weakness;Muscular Atrophy;Myoblasts;Myopathy;Nerve Degeneration;nerve supply;neurogenesis;Neurons;novel;Obesity;Oxidative Stress Induction;Pathologic;Pathway interactions;Patients;Permeability;pharmacologic;Phase;Phosphorylation;Physiological;Physiology;precursor cell;prevent;PRKCA gene;Proliferating;Protein Biosynthesis;protein degradation;Protein Degradation Inhibition;Protein Kinase;Proteins;Quality of life;receptor;reduced muscle mass;Research;Role;Safety;sarcopenia;Signal Transduction;Skeletal Muscle;skeletal muscle wasting;skeletal muscle weakness;synthetic peptide;systemic inflammatory response;Techniques;Testing;Thinness;TNF gene;Translations;wasting;Wasting Syndrome

PROJECT_TITLE: The role of unacylated ghrelin in age-associated progressive muscle weakness and cachexia elicited by cancer.

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: GM

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: BERKELEY

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: NARRATIVE Many characters of interest in biomedicine evolved long ago and are fixed in a particular species, distinguishing it from unaffected relatives; finding the genes underlying any such ancient trait has been a central challenge in the field. We have developed a method, RH-seq, for genetic dissection of interspecies trait variation, and applied it in invertebrate models. We now propose to study how species-defining alleles confer their effects, alone and together, in a yeast model system, and we propose to port our approaches for interspecies genetics to mouse cells, with a focus on cellular senescence.

PI_NAMEs: BREM, RACHEL BETH (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Acceleration;Age;Aging;Alleles;Amino Acids;Architecture;Behavior;biological adaptation to stress;Biological Assay;Biological Models;Biology of Aging;Candidate Disease Gene;Case Study;Cell Aging;Cell model;Cells;Chromosome Mapping;Complex;Data;Dissection;Evolution;experimental study;Funding;Genes;Genetic;genetic architecture;Genetic Epistasis;Genetic Population Study;Genetic Variation;Genome;genome-wide;Goals;Hybrids;Individual;Inflammation;Inflammatory;innovation;interest;Invertebrates;Laboratories;Literature;Mammals;Maps;Metabolism;method development;Methods;Modeling;Molecular;molecular phenotype;mouse model;Mus;Nature;Nematoda;Organism;Partner in relationship;Pathology;Phenotype;Polygenic Traits;programs;Proteins;Recombinants;Recording of previous events;reproductive;Saccharomyces cerevisiae;screening;senescence;senescent cell;Sister;Sterility;Stress;Surveys;System;Testing;Time;tool;trait;Variant;Work;Yeast Model System;Yeasts

PROJECT_TITLE: Mapping deep evolutionary divergences in cellular models of stress response

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Palliative Care

ORG_CITY: DURHAM

ORG_NAME: UNIVERSITY OF NEW HAMPSHIRE

ORG_STATE: NH

PHR: Fostering Ethical Adoption of Artificial Intelligence-Enabled Assistive Robots (AIAR) Grounded in Person-Centered Dementia Care. Our research addresses a crucial gap in dementia care, where the use of AI-assisted robots often overlooks the involvement of people living with dementia (PLWD) in the decision-making processes about their care. This can lead to a sense of dehumanization and a violation of personal autonomy. Our project aims to revolutionize this approach by developing the first intervention protocol that centers on person-centered engagement of PLWD in continuous decision-making, transitioning from a solely efficiency-driven use of technology to the ethical adoption that enhances the well-being and autonomy of PLWD and their care partners.

PI_NAMEs: WANG, JING  (contact)

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: acceptability and feasibility;Accounting;Address;Adopted;Adoption;Adult;Age;aging in place;Alzheimer's Disease;Artificial Intelligence;assistive robot;care outcomes;Caregivers;Caring;cognitive ability;Collaborations;Communication;Complex;Consent;Cues;Decision Making;Dehumanization;Dementia;dementia burden;dementia care;design;Disease;Distress;efficacy testing;Emerging Technologies;empowerment;Ensure;Ethicists;Ethics;experience;Fostering;Foundations;Future;Goals;Health Care Costs;Health Technology;Home;Home environment;human dignity;improved;insight;Intervention;Interview;Learning;marginalized population;Modeling;Morals;multidisciplinary;Nature;older adult;Perception;person centered;Personal Autonomy;Personal Satisfaction;Personality;personalized care;Persons;Pragmatic clinical trial;preference;preservation;Privacy;Process;Productivity;Protocols documentation;psychosocial;Quality of Care;Quality of life;Recording of previous events;Research;Resistance;Rights;robot assistance;Robotics;social stigma;socioeconomics;Technology;technology platform;technology validation;Testing;therapy design;Treatment/Psychosocial Effects;user centered design

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-H (O1)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: This project narrative is for the parent award (R01 HL165251) and does not include information related to the proposed diversity supplement activities. PROJECT NARRATIVE. Leakage of the tricuspid valve, which is located between the right atrium and right ventricle, is extremely common and, if not treated, can significantly impact the health of patients. The current gold-standard for treatment is a surgical approach known as tricuspid annuloplasty, which unfortunately does not have high long-term success rates and fails in approximately one third of patients. This proposal is relevant to public health as we aim to better understand a new tricuspid valve disease mechanism, tricuspid valve maladaptation, that could be used as future therapeutic target toward improving the currently poor outcomes for patients with tricuspid valve regurgitation.

PI_NAMEs: RAUSCH, MANUEL KARL (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: American;Benefits and Risks;Biological;Chronic;Death Rate;Disease;Extravasation;Fibrosis;Future;Health;high risk;improved;In Vitro;innovation;Intervention;Knowledge;Mechanics;Modeling;new therapeutic target;Operative Surgical Procedures;Outcome;parent project;patient population;Patient-Focused Outcomes;Patients;Phenotype;prophylactic;Public Health;Pulmonary Hypertension;Recurrence;repair strategy;Repeat Surgery;Right atrial structure;right ventricular remodeling;Right ventricular structure;sheep model;Speed;standard care;Stimulus;success;Techniques;Testing;Therapeutic;therapeutic target;Three-Dimensional Imaging;Tissues;Tricuspid Valve Insufficiency;Tricuspid valve structure;Work

PROJECT_TITLE: Using an Electrospun Surrogate Model to Investigate Mechanisms of Tricuspid Valve Maladaptation

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: DE

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Regenerative Medicine

ORG_CITY: NEWARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: NEW JERSEY INSTITUTE OF TECHNOLOGY

ORG_STATE: NJ

PHR: Project Narrative: Trauma and bacterial infections often necessitate extirpation of dental pulp. Regenerating the soft vascularized tissue in the canal is a major unmet clinical goal. We’ll develop a peptide hydrogel formulation that promotes vascularized soft tissue after pulpectomy, with low risk of bacterial colonization.

PI_NAMEs: KUMAR, VIVEK  (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: Adolescent;Adoption;Adult;American;Amino Acids;amphiphilicity;angiogenesis;Animals;antimicrobial;Antimicrobial Effect;Apical;Applications Grants;Architecture;arteriole;Bacteria;Bacterial Infections;Binding;Biodegradation;Biological;Biological Assay;biomaterial compatibility;Biomedical Engineering;Biomimetics;biophysical analysis;biophysical properties;Blood Vessels;canine model;Canis familiaris;Cell Membrane Permeability;Cells;Cellular Infiltrate;Circulation;Clinical;Coculture Techniques;combinatorial;Complex;cone-beam computed tomography;Cues;Cuspid;Data;Dental;Dental caries;Dental Pulp;Dental Pulp Necrosis;Dentin;Deposition;Effectiveness;efficacy evaluation;Endodontics;Endothelial Cells;Endothelial Growth Factors Receptor;Enzyme-Linked Immunosorbent Assay;Evaluation;Evolution;Excision;Exhibits;experimental study;Exposure to;Extracellular Matrix;Flow Cytometry;Formulation;Future;Gel;Goals;Growth;Growth Factor;Hindlimb;Histologic;Hydrogels;implant material;implantation;improved;In Vitro;in vivo;in vivo regeneration;Infection;Infection prevention;Infiltration;Inflammation;Injectable;Injury;instrument;instrumentation;Ischemia;KDR gene;Kinetics;Learning;Mammalian Cell;Mechanics;Membrane;meter;Microbe;Microbial Biofilms;mimetics;mineralization;Modality;Modeling;Modification;multidisciplinary;nanofiber;Natural regeneration;Nerve;Neurons;Nonvital Tooth;Odontoblasts;Oral;oral bacteria;oral biology;oral pathogen;Outcome;Pain;Patients;PECAM1 gene;Peptide Signal Sequences;Peptides;periapical;Peripheral;permanent tooth;Permeability;Phosphorylation;Physiologic Ossification;Positron-Emission Tomography;preclinical efficacy;preservation;prevent;Procedures;Proliferating;Property;Publishing;Pulp Canals;Pulpectomy;radiological imaging;receptor;Recurrence;regenerative;Regenerative research;Reporting;Research Personnel;Research Project Grants;Rest;Risk;Rodent;Rodent Model;Safety;self assembly;Signal Transduction;single photon emission computed tomography;soft tissue;Source;Specialist;Structure;success;Surface Plasmon Resonance;Techniques;Testing;Time;tissue regeneration;Tissues;tongue papilla;Tooth structure;transcriptome sequencing;Translating;Trauma;Variant;Vascular Endothelial Growth Factors;Vascularization;venule;Vertebral column

PROJECT_TITLE: Angiogenic and anti-microbial supports for pulp regeneration

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative The Reproductive Scientist Development Program (RSDP) plan for career development serves as a model for postgraduate medical education and assures that some of the most promising young physician- investigators in the country will remain in academic investigative obstetrics and gynecology. Despite an urgent need for research in gynecologic oncology, less than 1 in 5 of the 114 RSDP trainees to date have represented that subspecialty. This supplement grant seeks a new funding source specifically directed to attracting, training and retaining gynecologic oncologists as career physician scientists.

PI_NAMEs: SCHUST, DANNY J (contact)

PROGRAM_OFFICER_NAME: SEN, ARITRO

PROJECT_TERMS: Address;Basic Science;career;career development;Cellular biology;Clinical;Dedications;Discipline of obstetrics;Doctor of Philosophy;Ensure;experience;Faculty;faculty mentor;Fellowship;Funding;Goals;Gynecologic Oncology;Gynecologist;Gynecology;Individual;Institution;Laboratory Research;Medicine;member;Mentorship;Mission;Molecular Biology;multidisciplinary;National Institute of Child Health and Human Development;Phase;Physicians;Program Development;programs;Recording of previous events;reproductive;Reproductive Biology;Reproductive Medicine;Reproductive Sciences;Research;Research Methodology;Research Support;Residencies;Science;Scientist;Supervision;Time;Training;Wages


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Attention Deficit Hyperactivity Disorder (ADHD);Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Studies in animal models and humans support the notion that disease-causing mutations for frontotemporal dementia (FTD) and Alzheimer's disease (AD) may play critical roles in neurodevelopment. By studying children carrying mutations causing FTD or AD, this proposal will characterize and identify how early disease- specific neural circuit differences arise. These findings will reveal important insights into the underlying biology of these diseases and will determine how early biomarker trajectories in genetic FTD and AD diverge from trajectories in noncarriers.

PI_NAMEs: LEE, SUZEE EURIE (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Adult;Age;aged;Alzheimer's Disease;Amygdaloid structure;Animal Model;Attention;Attention deficit hyperactivity disorder;autism spectrum disorder;autistic children;autosome;behavior measurement;Behavioral Symptoms;behavioral variant frontotemporal dementia;Bilateral;Biological Markers;Biology;Brain;Child;Clinical;Cognitive;comparison control;Corpus striatum structure;Cross-Sectional Studies;Data;Differential Diagnosis;Disease;disease-causing mutation;DNA Sequence Alteration;Dominant Genes;Dyslexia;early detection biomarkers;Early identification;executive function;Family;Family member;frontal lobe;Frontotemporal Dementia;Functional Magnetic Resonance Imaging;Genetic;gray matter;Human;Inferior;insight;Insula of Reil;Language;Learning Disabilities;Left;Life;life span;Memory;Modeling;Mutation;mutation carrier;neural circuit;neural network;Neurobehavioral Manifestations;Neurodegenerative Disorders;neurodevelopment;Neurodevelopmental Disorder;neuroimaging;Pattern;Performance;Phase;Play;presenilin-1;Primary Progressive Aphasia;Resources;Role;Structure;Symptoms;Syndrome;white matter;Work;young adult

PROJECT_TITLE: Neurodevelopment in children from families with genetic frontotemporal dementia and Alzheimer’s disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative The parent grant aims to use two different imaging modalities to identify spatial changes in metabolites and proteins during the progression of Alzheimer's disease. In this supplement, we will focus on changes associated with astrocytes by comparing the dorsolateral prefrontal cortex to the primary visual cortex, to determine the changes in location, morphology, cell state, and cell interactions that contribute to regional neuronal vulnerability in Alzheimer's disease. Outcomes from this study will provide insights into the astrocytic mechanisms contributing to neurodegeneration and reveal targets that could be protective in Alzheimer's disease.

PI_NAMEs: MALLICK, PARAG KUMAR;SCHIAVINATO EBERLIN, LIVIA ;VARGHESE, MERINA THEKENANGARPADIYIL (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Alzheimer's Disease;Area;area striata;Astrocytes;Autopsy;Blood Vessels;Brain;Cell Communication;cell type;Cells;Chimera organism;Clinical;Coculture Techniques;comparison control;Data;Data Set;Detection;Development;Disease;Disease Progression;Experimental Models;Funding;Genetic Transcription;Grant;Heterogeneity;hippocampal pyramidal neuron;Human;humanized mouse;Image;Imaging Device;imaging modality;Imaging Techniques;Immunofluorescence Immunologic;insight;Intervention;large datasets;Location;mass spectrometric imaging;Mass Spectrum Analysis;Metabolic;metabolic imaging;Metabolic Pathway;Modeling;Molecular;Morphology;neocortical;Nerve Degeneration;Neuroglia;Neurons;neuropathology;novel;Organoids;Outcome Study;parent grant;Pathologic;Phenotype;Prefrontal Cortex;Proteins;Proteomics;Resolution;risk variant;Severities;Signal Pathway;Signaling Protein;small molecule;Specimen;System;Testing;tool;Validation;validation studies

PROJECT_TITLE: Mass spectrometry and multiplexed immunofluorescence imaging of metabolic and proteomic contributors to selective neuronal vulnerability in Alzheimer's disease


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Immunotherapy;Inflammatory Bowel Disease;Microbiome

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Gut microbiota are important in the regulation of intestinal homeostasis and the pathogenesis of inflammatory bowel disease, a chronic intestinal inflammation. However, it is unclear how this occurs. We will investigate whether a cellular protein, STING, which senses gut bacterial products, promotes T cell production of IL-10, an anti-inflammatory molecule, leading to the preservation of intestinal immune homeostasis and the inhibition of inflammatory bowel disease.

PI_NAMEs: CONG, YINGZI  (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: Acute;Affect;Agonist;Anti-Inflammatory Agents;Antigens;Autoimmune Diseases;autoinflammatory diseases;CD4 Positive T Lymphocytes;Cell Physiology;Cells;Chronic;Colitis;conditional knockout;Cyclic GMP;cytokine;Cytoplasm;Data;Defense Mechanisms;Dendritic Cells;Development;dextran sulfate sodium induced colitis;Dinucleoside Phosphates;Disease;DNA;DNA receptor;Drug Targeting;Equilibrium;experimental study;extracellular;Flagellin;Gene Expression Regulation;Genes;gut bacteria;gut colonization;gut inflammation;gut microbiota;Health;helicase;Homeostasis;Host Defense;IL17 gene;Immune;Immune system;Inflammatory;Inflammatory Bowel Diseases;insight;Interferons;Interleukin-10;interleukin-22;intestinal barrier;intestinal homeostasis;intestinal tumorigenesis;Intestines;IRF4 gene;Kinetics;knockout gene;Knockout Mice;Lead;Maintenance;Malignant Neoplasms;Mediating;microbiota;microorganism;Modeling;Mucosal Immune System;Mus;novel;Nucleic Acids;pathogen;Pathogenesis;pathogenic microbe;Pathway interactions;Periodicity;Play;preservation;prevent;Prevention;Production;Protein Family;Proteins;Regulation;Reporting;Role;sensor;Signal Transduction;STAT3 gene;Stimulator of Interferon Genes;Stimulus;T cell regulation;T cell therapy;T-Lymphocyte;Testing;Viral

PROJECT_TITLE: STING signaling in T cells regulation of intestinal homeostasis and inflammatorybowel diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-B(03)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Pediatric;Physical Activity;Prevention;Sleep Research;Telehealth

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE  Few young children meet the recently adopted World Health Organization recommendations for movement  behaviors (physical activity, sleep, and screen-time), known as the 24-Hour Movement Guidelines, putting  children at risk for more behavioral problems, poor cognitive development, delayed motor skills, and obesity.  This study will advance current literature by addressing all three behaviors together and within the setting  where all three behaviors occur, the home. This pilot study will evaluate the feasibility and preliminary  effectiveness of a theoretically grounded and home-based mHealth intervention to improve adherence to the  24-Hour Movement Guideline, and ultimately child mental and physical health.

PI_NAMEs: KRACHT, CHELSEA L (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Accelerometer;Address;Adherence;Adopted;Applied Research;Beds;Behavior;behavior change;Behavior Therapy;career;Caregivers;Characteristics;Child;Child Behavior;Child Mental Health;cognitive development;Complement;Control Groups;Data;design;Development;Devices;Ecological momentary assessment;Effectiveness;Equilibrium;experience;Family;Feedback;Focus Groups;Future;Goals;Grant;Guidelines;Health;Home;Home environment;Hour;Household;improved;infancy;interest;Intervention;Intervention Studies;Interview;Length;Life;Life Style;Literature;Location;Low income;meetings;Mentors;Methods;mHealth;mhealth interventions;minority children;mobile application;Mobile Health Application;Modality;Motor Skills;Movement;movie;neglect;Obesity;Outcome;Parents;Pattern;Physical activity;physical conditioning;Pilot Projects;pilot test;Play;Population Heterogeneity;Positioning Attribute;Problem behavior;Process;programs;Randomized, Controlled Trials;Recommendation;Reporting;Research;Research Training;Resistance;Risk;Ritual compulsion;Sampling;Schedule;Seasons;sedentary;sedentary activity;Siblings;Sleep;Sleep Deprivation;sleep quality;Stress;Structure;Surveys;Tablets;Theory of Change;Time;tool;Training;tv watching;usability;Waiting Lists;World Health Organization;Writing

PROJECT_TITLE: A home-based intervention to improve adherence to the 24-Hour Movement Guidelines in young children


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric

ORG_CITY: Los Angeles

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE The craniofacial skeleton is composed of diverse tissue types and their precise integration during development is necessary for normal structure and function. We propose to use mouse and human genetics to reveal the mechanisms that coordinate development, assembly, and maintenance of the craniofacial skeleton as multi-tissue system. Our overall goal is to reveal new insights into the etiology of congenital craniofacial disorders and harness this knowledge for therapeutic innovations.

PI_NAMEs: MERRILL, AMY E (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Address;Award;Biology;bone;California;Cartilage;Communities;Congenital Disorders;Connective and Soft Tissue;Connective Tissue;Connective Tissue Cells;connective tissue development;craniofacial;craniofacial development;craniofacial disorder;Development;Developmental Biology;Diagnosis;Disease;Engineering;Ensure;Etiology;flexibility;Genes;Genetic;genetic variant;Goals;Grant;Head;Human;human disease;Human Genetics;human model;innovation;insight;Joints;Knowledge;Lead;Leadership;Maintenance;Mentors;Molecular;Molecular Biology;mouse genetics;National Institute of Dental and Craniofacial Research;novel;Pathway interactions;Pattern;Positioning Attribute;Process;Productivity;programs;Research;Research Personnel;Resources;Role;Services;Signal Transduction;skeletal;skeletal tissue;Skeleton;Societies;Structure;success;System;Techniques;Technology;Therapeutic;Thinking;Tissues;tool;Training;transcriptomics;Universities

PROJECT_TITLE: Regulating Skeletal Connectivity in Craniofacial Development and Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 CC (17)]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Mutations in basement membrane-associated genes cause amelogenesis imperfecta in humans. I will use mouse models to study an ameloblast-specific mineral ribbon attachment/elongation complex that is composed of these basement membrane-associated components. The completion of this proposal will advance our understanding of enamel formation, shed light on the therapeutic interventions of amelogenesis imperfecta, and provide insights for enamel biomimetics.

PI_NAMEs: LIANG, TIAN  (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Affinity Chromatography;Alleles;ameloblastin;Ameloblasts;Amelogenesis;Amelogenesis Imperfecta;autosome;Basement membrane;Biomimetics;biomineralization;career;career development;Collagen;Collagen Type XVII;Complex;conditional knockout;Defect;Dental Enamel;Dental Enamel Hypoplasia;Dentin;Dentin Formation;Development;Distal;Electron Microscopy;Enamel Formation;enamelin;Epithelium;Excision;Exhibits;Genes;Goals;Harvest;Human;Human Genetics;Immunohistochemistry;Immunoprecipitation;In Situ Hybridization;Incisor;Inner Enamel Epithelium;insight;Integrins;Integumentary system;Investigation;Ions;Junctional Epidermolysis Bullosa;Knockout Mice;Laboratories;LAMC2 gene;Laminin;Lead;malformation;Mass Spectrum Analysis;Membrane;mineralization;Minerals;Molecular;Molecular Analysis;mouse model;Mus;Mutation;Odontoblasts;Odontogenesis;Organ;Organogenesis;Phase;Phenotype;Process;professor;Proteins;Regulation;Research Design;Research Personnel;Research Project Grants;Role;Scanning Electron Microscopy;Series;Skin;System;tenure track;Therapeutic Intervention;Tissues;tool;Tooth structure;Training;Transgenic Mice;Update

PROJECT_TITLE: Ameloblast-specific mineral ribbon attachment/elongation complex in enamel formation


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: Chicago

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: NARRATIVE Dysregulation of molecular clock function in the placenta is a novel mechanism causing poor pregnancy outcomes, leading to lifelong health consequences for the newborn. This transdisciplinary project proposes a new, high impact virtual consortium that will advance fundamental knowledge into chemically-induced dysregulation of the molecular clock in the placenta. This work will transform our understanding of pregnancy disorders stemming from environmental exposures and set the basis for targeting preventive approaches related to the molecular clock.

PI_NAMEs: VEIGA-LOPEZ, ALMUDENA  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Birth;Cell model;cell motility;Cell Physiology;Cells;Chemical Exposure;Chemicals;Childhood;circadian;circadian pacemaker;Clock protein;cohort;Collaborations;Data;Development;Disease;environmental chemical;Environmental Exposure;Epidemiologist;Epidermal Growth Factor;Epidermal Growth Factor Receptor;Farm;Fetal Development;Fetus;Functional disorder;Genes;Gestational Age;Growth;Health;Human;Hypertension;infant morbidity/mortality;Knowledge;Lead;maternal morbidity;Molecular;molecular clock;Mothers;mouse model;Newborn Infant;novel;offspring;Peripheral;pesticide exposure;Pesticides;Placenta;Play;Poison;Population;Pre-Eclampsia;Pregnancy;pregnancy disorder;Pregnancy Outcome;Premature Birth;Preventive;reproductive outcome;Risk;Role;sex;Signal Transduction;Small for Gestational Age Infant;stem;Toxic effect;virtual;Work;Working Women

PROJECT_TITLE: Chemical exposure disruption of the placental circadian clock


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Nanotechnology;Prevention;Women's Health Research

ORG_CITY: MORGANTOWN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because misdiagnosis is prevalent in younger women with dense breast tissue receiving breast cancer screening, which causes missed cancers, needless follow up testing, anxiety, and increased medical costs. We seek to be the first to characterize an innovative imaging agent by complementary MRI and optical imaging within a micro-device that mimics the environment of breast cancer. This new MRI contrast agent is expected to expedite, simplify, and enhance the accuracy of breast cancer diagnosis in the clinic to improve patient outcome and reduce wasted medical dollars.

PI_NAMEs: BENNEWITZ, MARGARET  (contact)

PROGRAM_OFFICER_NAME: ZHANG, HUIMING

PROJECT_TERMS: 3-Dimensional;Address;Anxiety;Award;Benign;Blood;Breast Cancer Cell;Breast Cancer Detection;breast cancer diagnosis;Breast Cancer Early Detection;Breast Magnetic Resonance Imaging;chelation;Clinic;Clinical Trials;Contrast Media;Data;Encapsulated;Endosomes;Engineering;Environment;Evaluation;Exhibits;Extracellular Space;follow-up;Gadolinium;Goals;imaging agent;imaging detection;improved;in vivo;innovation;Label;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammography;manganese oxide;Medical Care Costs;Medical Imaging;Medical Waste;Methods;microdevice;Microfluidics;Modeling;Mucin 1 protein;Mus;nano;nanomaterials;neoplastic cell;Normal tissue morphology;novel;optical imaging;overexpression;particle;Patient-Focused Outcomes;Peptides;Performance;portability;preclinical development;Public Health;recruit;Research;Safety;Science;Signal Transduction;Specificity;Testing;Time;Toxic effect;Training;tumor;undergraduate student;Universities;West Virginia;Work;young woman

PROJECT_TITLE: Finding NEMO's Switchable MRI Signal Using Microfluidic Tumor Models


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Cancer;Eye Disease and Disorders of Vision;Genetics;Hematology;Immunotherapy;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: CORAL GABLES

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Narrative Allogeneic hematopoietic stem cell transplants (HSCT) are used to treat lymphoid malignancies, metabolic disorders and anemias / thalassemia. Ocular GVHD (oGVHD) with dry eye and ocular discomfort significantly reduces quality of life and occurs in more than 60% of patients that receive an aHSCT. In this proposal, we will use unique pre-clinical models to understand why the eye is a target tissue in GVHD and develop new translational targeted immunotherapies to locally prevent and treat oGVHD.

PI_NAMEs: LEVY, ROBERT BENJAMIN;PEREZ, VICTOR L (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Affect;Alloantigen;Allogenic;Anemia;Anti-Inflammatory Agents;Antigen Presentation;Antigen Presentation Pathway;Antigen-Presenting Cells;Antigens;Biological;Bromodomain;Bromodomains and extra-terminal domain inhibitor;Caring;CD4 Positive T Lymphocytes;CD8B1 gene;Cells;Chimera organism;Chimeric Proteins;Complex;conjunctiva;Cornea;Critical Pathways;cytokine;Development;Disease;druggable target;Dry Eye Syndromes;epigenetic regulation;Eragrostis;experimental study;Eye;Eye Development;eye dryness;Family;Formulation;FOXP3 gene;Frequencies;Funding;Future;Gastrointestinal tract structure;Genes;Genetic Diseases;genetic signature;Genetic Transcription;graft vs host disease;Grant;Hematologic Neoplasms;Hematopoietic;Hematopoietic Stem Cell Transplantation;IL2RA gene;Image Cytometry;Immune;Immune Targeting;immunodeficiency;Immunologics;Immunotherapy;improved;in vivo Model;Infiltration;Inflammatory;inhibitor;insight;Interleukin-2;Keratopathy;Kinetics;lacrimal;Lacrimal gland structure;Life;Liver;Malignant lymphoid neoplasm;Mediating;Metabolic Diseases;Modeling;Mus;nano-string;Nerve;novel;ocular surface disease;Oncogenic;Organ;Pain;Palliative Care;Pathologic;Pathway interactions;Patients;Pattern;Perforation;Pharmaceutical Preparations;Population;Pre-Clinical Model;prevent;Prevention;Proteins;Quality of life;Reagent;receptor;Receptor Signaling;Regulatory T-Lymphocyte;Reporter;Role;single-cell RNA sequencing;Skin;standard of care;Structure;Survival Rate;T-Lymphocyte;Testing;Thalassemia;Therapeutic;Time;Tissues;TNF gene;Transgenic Organisms;Translating;Tumor Necrosis Factor Receptor;Vision;Visual impairment

PROJECT_TITLE: Immune Mechanisms in Ocular Graft versus Host Disease


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: PHILADELPHIA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE: Delivery of broadly neutralizing antibodies against HIV at the time of antiretroviral therapy initiation can enable immune-mediated control of HIV infection in some people living with HIV after therapy is stopped. Here we will perform mechanistic and discovery based strategies to understand how this therapeutic strategy affects the long-lived HIV reservoir and improves HIV-specific immune responses in some individuals but not others. Understanding how infected cells survive and persist within the body will allow targeted development of HIV cure strategies.

PI_NAMEs: BETTS, MICHAEL R (contact);JONES, BRAD R;SØGAARD, OLE SCHMELTZ

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: adaptive immune response;Address;Affect;antagonist;Anti-viral Therapy;Antibody Therapy;antiretroviral therapy;BCL1 Oncogene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Physiology;Cell Surface Proteins;Cell Survival;Cells;Clinical;Clinical Trials;Development;Disease remission;Early Intervention;effector T cell;Engraftment;Epigenetic Process;Epitopes;feature selection;Frequencies;Future;Gene Expression Profile;Goals;HIV;HIV Infections;HIV-1;Human;humanized mouse;Immune;Immune response;Immunity;Immunologics;Immunotherapy;imprint;improved;in vivo;Individual;Infection;Infusion procedures;Interferon Type II;Interruption;Intervention;Measures;Mediating;mouse model;National Institute of Allergy and Infectious Disease;neutralizing antibody;novel;Outcome;Participant;Persons;Phase;Phenotype;Plasma;Poland;preservation;Property;Reporting;Resistance;response;Sampling;success;System;T cell response;T-Lymphocyte;Therapeutic;Time;transcriptomics;Universities;Validation;Viral;Viral reservoir;Virus;Xenograft procedure

PROJECT_TITLE: Early interventions at ART initiation to reduce the HIV-1 reservoir and enhance adaptive immune responses

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Genetics;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Project Narrative Not applicable

PI_NAMEs: RHEE, JUNE-WHA  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Adherence;Affect;Animal Model;Area;Biochemical;Biological Assay;Biotechnology;Blood;Calcium;Cardiac;Cardiac Myocytes;cardiovascular health;Cardiovascular system;Cell Death;Cell Differentiation process;Cell Line;Cell Membrane Permeability;Cell Respiration;Cells;Cholesterol;Clinic;Clinical;Code;cofactor;Complex;Coronary heart disease;Coupled;CRISPR interference;diagnostic tool;Disease;Endothelial Cells;Engineering;Evaluation;gene function;gene network;Genes;Genetic Polymorphism;Genetic Predisposition to Disease;Genetic study;genome wide association study;genome-wide;Genotype;Glucose;Grant;Guide RNA;Homeostasis;Human;improved;in vivo;induced pluripotent stem cell;induced pluripotent stem cell technology;Injury;Investigation;knock-down;Lead;Libraries;Life;loss of function;Luciferases;Mediating;Medical;Medicine;Membrane Transport Proteins;Metabolic;Metabolic dysfunction;Metabolism;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Modeling;Molecular;Molecular Target;Monitor;mouse model;Muscle;Muscle Cells;Muscle Fibers;Muscle Weakness;Myalgia;Myopathy;Nicotinamide adenine dinucleotide;novel;novel diagnostics;Oxidation-Reduction;Oxidative Stress;Oxidoreductase;Pathogenesis;patient derived induced pluripotent stem cells;patient subsets;patient tolerability;Patients;Phenotype;pleiotropism;Predisposition;prevent;Protocols documentation;Qi;Reaction;recruit;Reporter;Reporting;Research;Research Personnel;Research Training;Resistance;response;Rhabdomyolysis;Role;screening;skeletal;Skeletal Muscle;Stress;Symptoms;Technology;Testing;Toxic effect;transcriptomics;Treatment Efficacy;United States National Institutes of Health;uptake;Variant

PROJECT_TITLE: Patient-specific modeling of metabolic dysfunction in statin-induced myopathy using iPSC-derived myocytes

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative The overall vision is to establish a craniofacial bone disease program focusing on skeletal stem cell plasticity as a central mechanism of craniofacial bone formation in intramembranous and endochondral pathways. This proposal aims to develop a research program addressing fundamental mechanisms of craniofacial bone diseases from the perspective of skeletal stem cells and their lineage plasticity. The research program is expected to establish skeletal stem cell dysregulation as a fundamental tenet of craniofacial bone diseases, which will serve as a critical therapeutic target of clinically prevalent conditions in autotherapies.

PI_NAMEs: ONO, NORIAKI  (contact)

PROJECT_TERMS: Address;bone;Bone Development;Bone Diseases;Bone necrosis;career;Cells;Chondrocytes;Clinical;clinical translation;Collaborations;condylar cartilage;craniofacial;craniofacial bone;craniofacial complex;Deformity;Deglutition;Dental General Practice;Disease;disease model;Future;genetic approach;Genetic Induction;genetic manipulation;high dimensionality;in vivo;Jaw;Knowledge;late life;Mandible;Mastication;maxillofacial;Molecular;mouse genetics;novel;Oral;Osteogenesis;Pathway interactions;practice setting;Predisposition;Productivity;programs;regeneration potential;regenerative;Research;Respiration;response;Scientist;skeletal stem cell;skull base;stem cell population;stem cells;Surgeon;therapeutic target;transcriptomics;Vision;Weight-Bearing state

PROJECT_TITLE: Skeletal stem cell plasticity in craniofacial bone diseases.


ADMINISTERING_IC: OH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: ATHENS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Public Health Narrative Commercial fishermen in Georgia and surrounding states work long hours in challenging conditions, leading to greater risk for and prevalence of injury and mortality relative to other types of occupations. The proposed program will systematically adapt and refine an existing fishermen first aid and safety course, and then implement that course for fishermen along the Georgia coast. Using a community-engagement approach we aim to reduce injury among fishermen, increase the number of instructors certified to provide safety training, and improve quality of life for the fishing community.

PI_NAMEs: FLUECH, BRYAN ;GAY, JENNIFER L (contact)

PROGRAM_OFFICER_NAME: GARRETT, BRIDGETTE E

PROJECT_TITLE: Translating the Fisherman First Aid and Safety Training (FFAST) for Commercial Fishermen in the Southeastern United States

STUDY_SECTION_NAME: Special Emphasis Panel[ZOH1 LEE (10)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: RALEIGH

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: Project Narrative Not Required for PA-23-189: Research Supplements to Promote Diversity in Health-Related Research (Admin Supp Clinical Trial Not Allowed)

PI_NAMEs: GUILLUY, CHRISTOPHE DANIEL (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Clinical Trials;Health;Neuroglia;Regulation;Research;response;Transcription Factor AP-1

PROJECT_TITLE: Regulation of AP1 in response to glial cell compression

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


NIH_SPENDING_CATS: Bioengineering;Regenerative Medicine

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative (Parent Grant) The proposed research is relevant to public health and aims at understanding how coordinated approaches can be used to rapidly guide microvascular development. This will enable new and translatable reconstructive approaches for tissue loss, and broadly advance regenerative medicine.

PI_NAMEs: RAVNIC, DINO J;SHEIKHI, AMIR  (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TITLE: Diversity Supplement: Manipulation of Host Tissue to Induce a Hierarchical Microvasculature

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE This diversity supplement aims to build evidence on how an intervention to improve housing stability affects child mental health among those whose parents have been incarcerated. We will embed a qualitative study and a cohort study to explore the mental health of youth and their parents within an ongoing hybrid type 1 effectiveness/implementation study of an intervention that provides comprehensive financial education and financial support for housing in the form of rental assistance, down payment assistance, and low-interest home loans among family members of incarcerated people. This supplement will provide Dr. Destiny Tolliver with necessary skills to build an independent research career in the field of child mental health equity.

PI_NAMEs: ROY, BRITA ;SPELL, VIRGINIA T;WANG, EMILY AI-HUA (contact)

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: adolescent mental health;Affect;Aggressive behavior;Automobile Driving;Behavior;Black race;career;Child;Child Mental Health;cohort;Cohort Studies;Disparity;Economics;Education;effectiveness/implementation study;experience;Family;Family member;Feasibility Studies;Feeling suicidal;Financial Support;Goals;Grant;health equity;Home;Housing;Hybrids;Imprisonment;improved;Infrastructure;interest;Intervention;intervention participants;Intervention Studies;Legal system;Mental Depression;Mental Health;novel;parent project;Parent-Child Relations;Parents;payment;peer;Persons;Policies;Research;skills;Structural Racism;substance use;supported housing;Symptoms;Trust;United States;violence exposure;Well in self;Youth

PROJECT_TITLE: Assessing TRUE HAVEN Housing Intervention Impact on Parent Experiences and Youth Mental Health


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: DREXEL UNIVERSITY

PHR: PROJECT NARRATIVE The Drexel FIRST initiative (Catalyzing Systemic Change at Drexel University to Support Diverse Faculty in Health Disparities Research) will create a collaborative structure involving University leaders, academic units and faculty to catalyze sustainable institutional change that supports scientific and inclusive excellence in the conduct of health disparities research. We will recruit 10 diverse early career scientists, support their career development, create sustainable institutional changes necessary to promote inclusive excellence broadly, and evaluate the outcomes of the program at multiple levels including scientific impact.

PI_NAMEs: DIEZ ROUX, ANA VICTORIA (contact);GITLIN, LAURA N.

PROGRAM_OFFICER_NAME: CALZOLA, JESSICA MARIE

PROJECT_TERMS: Address;Administrative Supplement;Aging;Appointment;Area;career;Career Choice;career development;Chronic Disease;clinical practice;Collaborations;college;Communities;Discipline of Nursing;Disparity;Ensure;Equity;ethnic diversity;Ethnic Origin;evidence base;experience;Extramural Activities;Faculty;faculty support;Gender;Goals;Health Disparities Research;health disparity;health equity;health inequalities;Health Occupations;improved;Individual;Inequity;Institution;International;intersectionality;Intervention;Intervention Studies;Joints;learning community;Measures;Mentors;Mentorship;Methodology;Methods;multi-component intervention;novel;Outcome;pedagogy;Policies;population health;Population Sciences;Positioning Attribute;Program Evaluation;Program Sustainability;programs;Public Health Schools;Race;racial diversity;recruit;Research;Research Personnel;Research Proposals;Research Support;response;Science;Scientist;Social Justice;Social Values;Structure;success;tenure track;theories;Translating;underserved community;United States National Institutes of Health;Universities

PROJECT_TITLE: Catalyzing Systemic Change at Drexel University to Support Diverse Faculty in Health Disparities Research - Administrative Supplement


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Pediatric

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project narrative Given the complexity and multimodal nature of the input to the child, learning language should be a challenging task, but most young infants proceed in achieving language competence with enormous speed. We hypothesize that the alignment and use of multimodal cues, including touch, in the input may play a key role in this achievement and explore this hypothesis in a series of experiments. The primary translational signiﬁcance of this work is the potential to provide insights into language learning mechanisms, which ultimately could impact treatment protocols and interventions or parent-training programs with high-risk infants consistent with the mission of NIH.

PI_NAMEs: BOROVSKY, ARIELLE  (contact);SEIDL, AMANDA H

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: Achievement;Affect;age effect;Attention;Auditory;autism spectrum disorder;Behavioral;Caregivers;Child;Child Rearing;Clinical;clinically significant;Competence;Cueing for speech;Cues;Deceleration;design;Development;Early Intervention;Environment;experience;experimental study;Exposure to;Goals;Hearing;Heart Rate;high risk;high risk infant;improved;Infant;insight;Intervention;Knowledge;Label;Language;Language Delays;Language Development;Language Disorders;language outcome;Language Therapy;Learning;lexical;Linguistics;low socioeconomic status;Maps;mathematical ability;Measures;Mediating;Mission;Modality;multimodality;multisensory;Nature;Oral;parenting intervention;phonology;Physiological;Play;Research;Risk;Role;Semantics;sensor;Sensory;sensory input;sensory system;Series;Siblings;Signal Transduction;Smell Perception;social;sound;Speech;Speed;Stream;syntax;System;Tactile;Taste Perception;Temperature;Testing;Texture;theories;Time;Toddler;Touch sensation;Training Programs;Treatment Protocols;United States National Institutes of Health;Vision;Visual;visual tracking;word learning;Work

PROJECT_TITLE: Touch to learn: How sensory cues impact word segmentation and learning

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Sexually Transmitted Infections

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative Squamous cell cancer of the anus (SCCA) is increasingly common among the aging population of people living with HIV and recent, key studies have shown that immediate, early treatment of anal precancer after anoscopic screening and surveillance prevents invasive cancer. Unfortunately, current high resolution anoscopy (HRA) screening exams are limited by poor accuracy particularly with less experienced clinicians, inefficiency (separate patient visits for diagnosis and treatment), and patient discomfort (due to multiple false-positive biopsies). There is a great need for novel, culturally acceptable, community-based technologies that improve the accuracy and impact of HRA exams in low resource and community-based settings worldwide.

PI_NAMEs: ANANDASABAPATHY, SHARMILA  (contact);CHIAO, ELIZABETH Y.

PROGRAM_OFFICER_NAME: LIDDELL HUPPI, REBECCA

PROJECT_TERMS: Acetic Acids;Address;Administrator;Adoption;Aging;aging population;Algorithmic Analysis;Anus;Area;arm;Artificial Intelligence;Biopsy;Brazil;cancer invasiveness;Cervix Uteri;Clinical;Clinical Trials;cohort;Colposcopy;Communities;Computer Assisted;Computer software;contextual factors;cost;Coupled;Data;data repository;Decision Making;Detection;Development;Diagnosis;diagnostic accuracy;Early treatment;Effectiveness;efficacy evaluation;Ensure;Environment;Epithelium;Evaluation;experience;follow-up;Future;General Population;global health;Healthcare;high risk;Histologic;Histology;Histopathology;HIV;Image;Image Analysis;imaging approach;imaging platform;implementation facilitation;improved;Incidence;International;Lesion;Low income;Machine Learning;machine learning algorithm;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Malignant Squamous Cell Neoplasm;men who have sex with men;meter;microendoscope;Morphology;Multimodal Imaging;multimodal learning;multimodality;Neoplasms;novel;Optical Biopsy;Oral;Outcomes Research;Participant;Patients;Performance;Persons;point of care;point-of-care diagnostics;Population;practice setting;Predictive Value;premalignant;prevent;Prevention;primary care provider;primary outcome;Procedures;Provider;Reporting;research study;Resolution;Resource-limited setting;Resources;Risk;screening;Screening for cancer;secondary outcome;skills;Skin;Specificity;Squamous intraepithelial lesion;standard of care;Stomach;Technology;technology development;theories;Time;tool;Training;Visit

PROJECT_TITLE: The Effectiveness of Automated Multimodal Imaging in High Grade Squamous Intraepithelial Lesions (HSIL) Diagnosis for People Living with HIV: An International Trial

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-X (03)]


NIH_SPENDING_CATS: Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;HIV/AIDS;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Patient Safety;Pediatric;Pediatric - AIDS;Pregnancy;Prevention;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative (3 sentences) The HPTN 084 OLE allows for participants to discontinue contraception and if becoming pregnant to continue active dosing with CAB LA throughout pregnancy and breastfeeding. The HPTN 084 pregnancy substudy will provide important information for prevention of HIV in women during their years of reproductive potential, when they are often most vulnerable to HIV. In addition, the pregnancy substudy will provide valuable information about the safety and pharmacokinetics of CAB LA for pregnant and lactating people and their infants.

PI_NAMEs: BROWN, ELIZABETH RENATA;DONNELL, DEBORAH J (contact)

PROGRAM_OFFICER_NAME: DEJLI, JAMAL

PROJECT_TERMS: AIDS prevention;Biological Assay;Breast Feeding;Clinical Trials;Contraceptive methods;data management;design;Development;Dose;Drug Kinetics;Ectopic Pregnancy;electronic data;Electronics;experience;Faculty;Fred Hutchinson Cancer Research Center;Goals;Growth;HIV;HIV Vaccine Trials Network;Human Milk;Incidence;Infant;innovation;Institution;Laboratories;Lactation;Leadership;Low Birth Weight Infant;maternal safety;Oral;Outcome;Participant;Perinatal;Persons;Plasma;Postpartum Period;pre-exposure prophylaxis;Pregnancy;Pregnancy Outcome;pregnant;Reporting;reproductive;Research;Research Support;Safety;safety outcomes;Serious Adverse Event;Site;Specimen;Spontaneous abortion;Statistical Methods;surveillance study;Term Birth;Time;Umbilical Cord Blood;Weight Gain;Woman;Women's cohort

PROJECT_TITLE: SDMC: HPTN 084 Pregnancy Supplement


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Emergency Care;Health Services;Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation

ORG_CITY: Aurora

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The public health significance of GAPcare II is immense as it proposes a multidisciplinary care coordination program that addresses the Healthy People 2020 goals of preventing and reducing injuries and enhancing life independence among older adults. This project is directly responsive to NIA’s “Strategic Directions for Research on Aging”, section B5: Identify, analyze, and track changing patterns of disability and mortality for older adults and better understand factors contributing to these patterns. Dr. Goldberg’s technology-assisted fall prevention intervention could provide a model of care to reduce subsequent falls in high-risk emergency department seniors and supports the further training of Dr. Goldberg to become a leader in geriatric emergency care.

PI_NAMEs: GOLDBERG, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: Accident and Emergency department;Acute;acute care;Address;Aging;Apple watch;Award;care coordination;career;Caregivers;Caring;Clinical Trials;collaborative approach;Data;Data Analyses;digital health;disability;Elderly;Emergency Care;Emergency Department patient;Emergency department visit;Emergency Medicine;Epidemiologist;Epidemiology;Fall prevention;fall risk;falls;field study;Future;Goals;Health Policy;Health Services;Health Services Research;Healthy People 2020;high risk;Home;Impaired cognition;Injury;Intervention;Investigation;Leadership;Life;Measures;Medication Management;Mentors;Mentorship;Methods;Modeling;mortality;multidisciplinary;older adult;Outcome;Outpatients;Patients;Pattern;Pharmaceutical Preparations;Pharmacists;Pharmacy facility;physical therapist;Physicians;Pilot Projects;Policies;prevent;preventive intervention;programs;Protocols documentation;Public Health;Qualitative Research;Randomized, Controlled Trials;Recurrence;Rehabilitation therapy;Research;Research Personnel;Resources;Safety;Scientist;Specialist;Technology;Testing;Training;treatment as usual;usability;Work

PROJECT_TITLE: GAPcare II: The Geriatric Acute & Post-acute Care Coordination Program for Fall Prevention in the Emergency Department


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Primary Health Care;Social Determinants of Health

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE This program of research aims to identify and investigate the causal mechanisms of oral health inequities at the intersections of dental care access, utilization, and quality. Increased understanding of the multi-level mechanisms that produce population oral health disparities and inequities will facilitate effective translation of oral health programs, practices, or policies.

PI_NAMEs: HEATON, BRENDA  (contact)

PROGRAM_OFFICER_NAME: ELWOOD, WILLIAM N

PROJECT_TERMS: Awareness;Biological;Complex;Data;Dental Care;differences in access;Economics;Epidemiologist;Goals;health care service;health disparity;health equity;health inequalities;Health Services Accessibility;improved;Individual;innovation;insight;Investigation;Methodology;novel;Oral health;Patients;Policies;Population;population based;programs;Provider;psychologic;Research;Scientist;social;System;Translations;Underrepresented Populations

PROJECT_TITLE: Advancing oral health equity through integrating patient, provider, and population-based approaches


ADMINISTERING_IC: TR

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

ORG_CITY: CORNELIUS

ORG_NAME: PHASE, INC.

ORG_STATE: NC

PHR: Diversity supplement narrative In order to grow a diverse workforce to help grow the biotech sector, we are helping to develop a Jamaican immigrant and now US citizen who has benn a vital part of our development of a novel way to create microfluidics using an automated lab process. Microfluidics (MF) are the test tubes of the digital age and play a vital role in drug discovery, biotechnology, lab- and organs-on-a-chip, personalized point-of-care diagnostics and treatment, disease research, and more. Phase, Inc. is developing a new 3D printing technology to create PDMS microfluidics that believe will fundamentally change the way PDMS microfluidics are fabricated and unlock the design freedom of additive manufacturing for the MF community, which will lead to significant advancements of in vitro MF models. This new 3D printing technology will allow researchers to quickly design and create microfluidic devices in a matter of hours – as opposed the weeks it now takes.

PI_NAMEs: SCHULTZ, JEFFREY  (contact)

PROGRAM_OFFICER_NAME: CROUCHER, LEAH TOLOSA

PROJECT_TERMS: 3-Dimensional;3D Print;Age;Architecture;Automation;Basement membrane;Biotechnology;Blood - brain barrier anatomy;Coculture Techniques;Collaborations;commercialization;Communities;Computer software;design;Development;Devices;digital;Dimensions;Disease;Diverse Workforce;drug discovery;Electrodes;Ensure;experimental study;Freedom;Grant;Hour;image processing;Immigrant;In Vitro;in vivo;Jamaican;Kinetics;Laboratories;Lasers;Legal patent;manufacture;Mechanics;Membrane;Microfluidic Microchips;Microfluidics;Microscope;Modeling;models and simulation;nanofiber;nanomembrane;novel;novel strategies;Optics;organ on a chip;Phase;Plasma;Play;point-of-care diagnostics;Printing;Process;Reproducibility;Research;Research Personnel;Rheology;Robotics;Role;Sampling;skills;Structure;success;System;Technology;Testing;timeline;Tube;Virginia

PROJECT_TITLE: ADDITIVE MANUFACTURING OF PDMS MICROFLUIDICS

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(12)-B]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Data Science;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE It remains largely unclear which genetic factors underlie well-established sex differences in Alzheimer’s disease (AD). This proposal will fill in this gap by using a series of state-of-the-art innovative approaches to discover sex- specific genetic risk variants for AD, including performing the largest sex-stratified genome-wide association study of AD to date, studying for the first time the role of X-chromosome and sex-specific rare variant effects on AD, and using rich proteomics data to discover new AD risk genes. Findings from this work will help gain important insights into the pathophysiology of AD, identify novel sex-specific risk factors relevant to personalized genetic medicine, and uncover potential new AD drug targets that may more optimally benefit both sexes.

PI_NAMEs: BELLOY, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TERMS: Affect;Age;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease risk;Amyloid;apolipoprotein E-4;autosome;Big Data;Biology;Brain;brain tissue;candidate validation;career;Cerebrospinal Fluid;Clinical;Cognitive;cohort;Coupled;Data;data harmonization;data integration;Data Set;Dementia;differential expression;Disease;Disease Progression;Drug Targeting;endophenotype;Energy Metabolism;exome;Fellowship;Functional disorder;gene discovery;Genes;Genetic;genetic association;Genetic Diseases;Genetic Medicine;Genetic Risk;genetic risk factor;Genetic study;Genetic Transcription;genetic variant;Genome;genome wide association study;genome-wide;genotypic sex;Goals;hazard;high risk;Image;improved;innovation;insight;large datasets;Late Onset Alzheimer Disease;Learning;Link;Maps;men;Mentors;Methods;Modeling;Molecular;Molecular Disease;Multiomic Data;multiple omics;Mus;Neurology;new therapeutic target;novel;Outcome;Parkinson Disease;Pathogenesis;Pathology;Pathway interactions;Persons;Phase;Phenotype;Postdoctoral Fellow;precision genetics;programs;Proteins;proteomic signature;Proteomics;rare variant;Research;Resources;Risk Factors;risk variant;Role;Sample Size;Sampling;Scientist;Series;sex;Sex Bias;Sex Differences;sexual dimorphism;skills;Source;Statistical Models;success;tau Proteins;Thick;Time;Training;Transcript;United States;Validation;Variant;Woman;Work;X Chromosome

PROJECT_TITLE: Elucidating sex-specific risk for Alzheimer's disease through state-of-the-art genetics and multi-omics


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Digestive Diseases;Immunotherapy;Nanotechnology;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: ATLANTA

ORG_DEPT: SURGERY

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative The outreach goal of the proposed research project is to develop a new combination of targeted drug delivery and immunotherapy for the treatment of advanced pancreatic cancer. Our innovative designs of tumor penetrating and immune modulating theranostic nanoparticles, coupled with a novel nanoparticle PD-L1 inhibitor (Nano-iPD-L1), enable efficient delivery of chemotherapy drugs and immunotherapy agents into stroma-rich pancreatic cancer tissues to destroy drug resistant tumor cells, modulate an immunosuppressive microenvironment into a pro-immune environment, and generate strong immune responses. Results of this translational research project have the potential for the development of a targeted and image-guided cancer therapy that significantly enhances therapeutic efficacy, and activates tumor specific immune response, and improves survival of pancreatic cancer patients.

PI_NAMEs: MAO, HUI ;YANG, LILY  (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: advanced pancreatic cancer;Affinity;Basement membrane;Biodistribution;Biological;Biology;cancer classification;cancer immunotherapy;Cancer Model;cancer therapy;cancer type;Catalytic Domain;CD8B1 gene;cell killing;cell type;Cells;checkpoint therapy;chemotherapy;Clinical;Combined Modality Therapy;Coupled;cytotoxic;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Dendritic Cells;design;Development;Disease;Distant;Dose;Doxorubicin;draining lymph node;Drug Carriers;Drug Delivery Systems;drug distribution;Drug Kinetics;Drug Monitoring;Drug resistance;Drug Targeting;Duct (organ) structure;Effector Cell;effector T cell;Engineering;Environment;Extracellular Matrix;Fibroblasts;Goals;Human;image guided;image guided therapy;image-guided drug delivery;imaging agent;Immune;immune cell infiltrate;immune checkpoint;Immune response;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;Infiltration;innovation;irinotecan;iron oxide nanoparticle;ITGAX gene;KRAS oncogenesis;Lead;Ligands;Macrophage;Magnetic Resonance Imaging;Magnetism;Malignant neoplasm of pancreas;Malignant Neoplasms;migration;MMP14 gene;Modeling;Monitor;mouse model;Mus;Myeloid-derived suppressor cells;nanoparticle;nanoparticle delivery;nanoparticle drug;neoplastic cell;novel;novel therapeutics;outreach;pancreatic cancer cells;pancreatic cancer model;pancreatic cancer patients;pancreatic neoplasm;patient derived xenograft model;PDL1 inhibitors;Penetration;Peptides;peptidomimetics;Pharmaceutical Preparations;Phenotype;PLAUR gene;Population;Prognosis;programmed cell death ligand 1;programmed cell death protein 1;Property;Proteins;Recombinants;Regulatory T-Lymphocyte;Research;Research Project Grants;Resectable;response;sialic acid binding Ig-like lectin;Signal Transduction;Spleen;Stromal Cells;success;targeted cancer therapy;targeted delivery;targeted treatment;theranostics;Therapeutic Effect;therapy resistant;Tissues;Transgenic Mice;Translational Research;Translations;Treatment Efficacy;treatment response;tumor;tumor growth;Tumor Promotion;tumor-immune system interactions;Urokinase Plasminogen Activator Receptor

PROJECT_TITLE: Stroma penetrating and immune modulating nanoparticles for image-guided therapy of pancreatic cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-V(02)M]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Kidney Disease;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: Project Narrative The identification of new focal segmental glomerulosclerosis (FSGS) and nephrotic syndrome (NS) genes and further genetic characterization of known FSGS/NS genes will have significant implications for understanding, and ultimately, treating, common forms of kidney disease and progression to kidney failure. In the more immediate future, identification and characterization of FSGS/NS gene defects will have implications for the development of diagnostic tools. !

PI_NAMEs: HILDEBRANDT, FRIEDHELM ;POLLAK, MARTIN R. (contact);SAMPSON, MATTHEW GORDON;SANNA-CHERCHI, SIMONE

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: Acceleration;Address;Affect;aggregation database;Alleles;analytical method;Animal Model;Biological Assay;Biological Models;Biology;Cells;Classification;Clinical;cohort;Collection;Communities;Complex;Copy Number Polymorphism;Data;data integration;data resource;Defect;Development;diagnostic accuracy;diagnostic development;diagnostic tool;Disease;disease model;empowerment;Enhancers;Etiology;exome;exome sequencing;Focal and Segmental Glomerulosclerosis;Future;gene discovery;Gene Frequency;gene interaction;Genes;Genetic;genetic disorder diagnosis;genetic profiling;genetic testing;Genetic Transcription;genetic variant;Genetic Variation;genome sequencing;genome-wide;Genomics;Genotype;Goals;Heritability;Human;human model;improved;Individual;induced pluripotent stem cell;Informatics;insertion/deletion mutation;Internet;Kidney;Kidney Diseases;Kidney Failure;Kidney Transplantation;Laboratories;Lead;Medical Genetics;Methods;Modeling;Molecular Structure;Mutate;Mutation;Nephrotic Syndrome;novel;nutritional supplementation;Outcome;parallelization;Pathogenicity;patient derived induced pluripotent stem cells;Patients;Penetrance;Phenotype;predicting response;Prevalence;promoter;Reagent;Reporting;Research;Research Personnel;response;Risk;Sample Size;Single Nucleotide Polymorphism;Site;SNP array;Standardization;Steroid therapy;Steroid-resistant idiopathic nephrotic syndrome;System;Technology;Test Result;Testing;Therapeutic;Variant;web portal;Work;Zebrafish

PROJECT_TITLE: Integrating large scale genomics and functional studies to accelerate FSGS/NS discovery


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Services;Methamphetamine;Opioid Misuse and Addiction;Opioids;Patient Safety;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PI_NAMEs: HUMPHREYS, KEITH N.;KORTHUIS, PHILIP TODD (contact)

PROGRAM_OFFICER_NAME: DOBBINS, RONALD

PROJECT_TERMS: addiction;Behavioral;Buprenorphine;California;Caring;Clinical Treatment;Clinical Trials;Clinical Trials Network;Clinics and Hospitals;Cluster randomized trial;Collaborations;Data Science;Drug abuse;Drug usage;Drug Use Disorder;Drug user;effectiveness/implementation trial;Electronic Health Record;experience;Future;Goals;Health;Health system;Healthcare;Helping to End Addiction Long-term;Hybrids;Hydromorphone;implementation trial;improved;Infrastructure;Intervention;Managed Care;Medicaid;medication for opioid use disorder;Methadone;methamphetamine use;Methamphetamine use disorder;mHealth;Mirtazapine;novel;Opiate Addiction;Opioid;opioid misuse;Oral;Oregon;peer;peer support;Persons;Pharmaceutical Preparations;Pharmacotherapy;phase III trial;Placebos;Primary Care;Protocols documentation;Public Health;Randomized;Research;Research Personnel;Resources;San Francisco;Science;Services;Site;Speed;success;Supervision;sustained recovery;Telephone;Testing;Training;trial comparing;Trillium;United States National Institutes of Health;Universities;Veterans;Vulnerable Populations


NIH_SPENDING_CATS: Cancer;Endocrine Disruptors;Prevention

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Title: NRF transcription factors in Environmental Stress and Disease Intervention PROJECT NARRATIVE  Chronic exposure to arsenic, an environmental contaminant that affects an estimated 160 million people worldwide, is a global public health concern. The goals of this R35 include in-depth mechanistic investigations of arsenic pathogenesis/NRF signaling and the translation of basic mechanistic knowledge into preclinical drug development. Completion of these goals will allow us to fill current gaps, advance environmental health research, and ultimately improve human health.

PI_NAMEs: ZHANG, DONNA D (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Address;Affect;Arsenic;cancer initiation;cancer type;Cellular Stress;Chronic;Darkness;diabetogenic;Disease;Environmental Health;Environmental Pollutants;Exposure to;Family member;Generations;Goals;Health;Human;improved;inhibitor;innovation;Intervention;Investigation;Knowledge;Malignant neoplasm of lung;Malignant Neoplasms;Molecular;Neoplasm Metastasis;Non-Insulin-Dependent Diabetes Mellitus;Oxidative Stress;Pathogenesis;Pathologic;Pathology;Pathway interactions;Persons;Preclinical Drug Development;prevent;programs;Public Health;Research;response;Risk;Role;Side;Signal Pathway;Signal Transduction;Stress;System;Therapeutic;therapy resistant;transcription factor;Translations;tumor progression;unpublished works;Up-Regulation;Vision

PROJECT_TITLE: NRF Transcription Factors in Environmental Stress and Disease Intervention


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: MIAMI

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

PHR: Project Narrative Puerto Rico faces frequent power outages due to the damage caused by natural disasters to its electric grid, which can in turn negatively affect the aging population (≥50 years) who are more likely to have multiple chronic health conditions. Research has demonstrated that access to energy independence through direct access to solar power can have positive health impacts on the population. We propose to explore, from a multilevel perspective, the perceived barriers and facilitators for adopting energy independence as described by individuals, communities, and policy makers, while also documenting resilience related variables that can explain effective chronic disease management among aging populations in need of electricity-based therapeutic treatments (i.e., renal disease, respiratory diseases, diabetes).

PI_NAMEs: PADILLA, MARK B;RODRIGUEZ MADERA, SHEILLA LEE;VARAS-DIAZ, NELSON  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: Address;Adopted;Affect;Aging;aging population;Altruism;American;Area;Caribbean region;Case Study;Categories;Cessation of life;Characteristics;Chronic;Chronic Disease;Climate;commune;Communities;community engagement;community organizations;comorbidity;Diabetes Mellitus;disaster resilience;Disasters;Disease;Disease Management;Disparity;Disparity population;Earthquakes;Electricity;Emotional;Enabling Factors;End stage renal failure;Energy-Generating Resources;Ethnography;Event;experience;extreme weather;Face;food marketing;Fostering;Funding;Geography;Government Agencies;Health;health disparity;health inequalities;Healthcare Systems;Hispanic Populations;Homes for the Aged;Hurricane;improved;Individual;Institution;Interruption;Intervention;Interview;Island;Kidney Diseases;Knowledge;Local Government;Location;Maps;member;Modeling;Morbidity - disease rate;mortality;Movement;multilevel analysis;Natural Disasters;Not Hispanic or Latino;optimism;Outcome;Patients;Persons;Policies;Policy Developments;Policy Maker;Population;population health;Positioning Attribute;Process;Pueblo Race;Puerto Rican;Puerto Rico;Recording of previous events;Recovery;Research;resilience;Respiratory Disease;response;Restaurants;Role;Rural;Sampling;Self Efficacy;Series;Solar Energy;Structure;Surveys;Technology;Therapeutic;Training;United States;United States National Institutes of Health;Vulnerable Populations;Work

PROJECT_TITLE: Disasters, solar energy, and chronic disease management in aging Puerto Ricans

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE The Microbiology lab at the Ryan Veterinary Hospital (PA-Ryan), located at the University of Pennsylvania School of Veterinary Medicine, currently oﬀers comprehensive microbiology and molecular biology veterinary diagnos�c services for companion animal and exo�c species. Over the past 5 years, PA-Ryan has been an ac�ve member of Vet-LIRN by expanding tes�ng op�ons and capacity, par�cipa�ng in mul�ple studies and proﬁciency/comparison exercises and developing methods. PA-Ryan serves companion animal veterinarians from the Commonwealth of Pennsylvania and throughout the United States making it an excellent ﬁt to con�nue as a VetLIRN laboratory.

PI_NAMEs: COLE, STEPHEN DOUGLAS (contact)

PROGRAM_OFFICER_NAME: CERIC, OLGICA

PROJECT_TITLE: Companion Animal and Animal Food Diagnostic Sample Analysis in Support of FDA Vet-LIRN Activities and Investigation.

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CVM-K (01)]


NIH_SPENDING_CATS: Clinical Research;Genetics;Hematology;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: IRVINE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: Revised Project Narrative This work may identify the genetic basis for the predisposition to acquire myeloproliferative neoplasm as well as develop a screening tool to identify those with this predisposition. This population at risk could then be targeted for preventative studies.

PI_NAMEs: FLEISCHMAN, ANGELA GOFFREDO (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Acceleration;Acetylcysteine;Affect;Age;aged;Aging;aging population;Agonist;Anti-Inflammatory Agents;Antioxidants;Attention;biobank;Biological Markers;Blood;Bone Marrow;Bone Marrow Stem Cell;Cell Cycle;cell type;Cells;ChIP-seq;Chronic;Clinical Trials;Clonal Hematopoietic Stem Cell;cytokine;Cytokine Receptors;Cytotoxic Chemotherapy;Data;Development;DNA Methylation;DNA sequencing;DNMT3a;Endowment;exhaustion;experimental study;Exposure to;Family;Family history of;Family member;Family-Based Registry;fitness;Gene Expression;Gene Expression Profiling;Genes;Genetic;Hematologic Neoplasms;Hematology;Hematopoiesis;Hematopoietic;hematopoietic stem cell emergence;hematopoietic stem cell quiescence;Hematopoietic stem cells;Human;Inflammation;Inflammatory;Interleukin-10;Ligands;Link;Lipopolysaccharides;Malignant - descriptor;member;Methylation;methylation pattern;Modeling;monocyte;mosaic;Mus;mutant;Mutation;Myeloproliferative disease;Oxidative Stress;Pathway interactions;Patients;peripheral blood;Persons;pharmacologic;Phenotype;Populations at Risk;Predictive Value;Predisposition;preservation;Prevalence;prevent;Prevention trial;Production;progenitor;Proliferating;Reactive Oxygen Species;Recombinant Interleukin-10;Recording of previous events;Regulation;Resistance;response;Role;Screening procedure;Signal Transduction;Sorting;stem;stem cell exhaustion;stem cell function;Stress;stressor;Testing;Therapeutic;TLR4 gene;TNF gene;Toll-like receptors;transcriptome sequencing;Translating;Transplantation;Wild Type Mouse;Work

PROJECT_TITLE: Role of IL-10R signaling in inflammation induced exhaustion of HSC and emergence of JAK2V617F clonal hematopoiesis

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ORG_CITY: DENVER

ORG_NAME: NATIONAL ENVIRONMENTAL HEALTH ASSOCIATION

PHR: PROJECT NARRATIVE The National Environmental Health Association (NEHA) project entitled A People-Centered, Technology-Driven, Scientific Approach to Advancing Conformance with the Voluntary National Retail Food Regulatory Program Standards (Retail Program Standards) is intended to:  • Build and implement a Flexible Funding Model system to provide significant subaward  funding to state, local, tribal, and territorial (SLTT) retail food regulatory programs, to  assist them in meeting the requirements of the Retail Program Standards,  • Assess and identify the retail training needs of SLTT agencies, and assist the US Food  and Drug Administration (FDA) in meeting those needs by building and establishing a  Retail Training Pre-Registration System; and  • Work with FDA to build and establish a National Retail Standardization Registry to  better promote and track retail Standardizations nationwide. These three objectives will advance the Integrated Food Safety System (IFSS) requirements found in the Food Safety Modernization Act (FSMA) and support the goal of building New Business Models and Retail Standardization in the New Era of Smarter Food Safety.

PI_NAMEs: DYJACK, DAVID T (contact)

PROGRAM_OFFICER_NAME: NIESEN, MARIBETH


ORG_CITY: DOVER

ORG_NAME: DELAWARE STATE UNIVERSITY

ORG_STATE: DE

PHR: Center for Research and Education in Multiscale Bioengineering, Bioimaging, and Biosensing (REMB3) Public Health Relevance The establishment of the Center for Research and Education in Multiscale Bioengineering, Bioimaging, and Biosensing (REMB3) at Delaware State University will strengthen the institutional research infrastructure necessary for the development of novel imaging and sensing technologies for improving human health. The Center will support investigators from different expertise who will team up to design novel biotechnologies with AI/machine learning capabilities. These biotechnologies will be tested and validated to become, for example, reliable diagnostic tools and treatment approaches of diseases or to create fair predictive tools for detection of early signs of diseases. All will translate into enabling and empowering the clinicians and stakeholders of the healthcare system P

PI_NAMEs: BOUKARI, HACENE  (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: Academic degree;Acceleration;Accreditation;Address;Agreement;Agriculture;Articulation;Award;bioimaging;Bioinformatics;Biological Sciences;Biology;Biomedical Engineering;Biomedical Research;Biomedical Technology;Biosensing Techniques;Biotechnology;career;Chemistry;Classification;Clinical;college;Communities;Competence;Data;Data Science;Degree program;Delaware;design;Development;Diagnosis;diagnostic tool;Discipline;Disease;Doctor of Philosophy;Early Diagnosis;Economic Development;Education;Educational Activities;Educational Curriculum;Educational process of instructing;Educational workshop;empowerment;Engineering;Enrollment;Entrepreneurship;Environment;Equity;equity, diversity, and inclusion;Ethics;experience;Fostering;Funding;Funding Opportunities;Genetic;Graduate Degree;Graduate Education;graduate student;Grant;Health;Healthcare;Healthcare Systems;Historically Black Colleges and Universities;Human;Image;improved;Incubators;Infrastructure;innovation;Institution;institutional capacity;Institutionalization;interest;Internships;Laboratories;Leadership;Machine Learning;Measures;Medical;Medical Technology;Mentors;Methodology;Modernization;multidisciplinary;Neurosciences;next generation;novel;novel imaging technology;Optics;Phase;photonics;Physics;Play;predictive tools;Privatization;programs;public health relevance;Race;recruit;Research;research and development;Research Infrastructure;Research Personnel;Research Support;Research Training;Resources;Role;Science;Scientist;sensor technology;Signal Transduction;socioeconomics;Sorbus;STEM field;Students;success;summer internship;Talents;Technology;technology development;Technology Transfer;technology validation;Testing;Training;Translating;undergraduate student;Underrepresented Populations;Universities;university student;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-E (O1)]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Coronaviruses;Dissemination and Implementation Research;Emerging Infectious Diseases;Genetics;Health Services;Infectious Diseases;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Social Determinants of Health;Telehealth

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative Studying gene expression signatures (RNA expression) in blood samples provides powerful insight into the molecular mechanistic changes induced by inflammation. Under the parent award, we developed a novel platform that enables at-home blood sampling and RNA stabilization, homeRNA. In this supplement we will conduct surveys and interviews to better understand experiences of U3 women who have used homeRNA in a longitudinal study, ultimately providing guidelines for the design of inclusive clinical studies and for the use of home sampling with telemedicine to increase healthcare access for U3 women.

PI_NAMEs: THEBERGE, ASHLEIGH BROOKS (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: 2019-nCoV;Address;Affect;analytical method;Appointment;Award;Bacteria;Biochemical;Biological Assay;Biological Markers;Biological Process;biomarker identification;Blood;Blood specimen;Cell Line;cell type;Cells;Chemicals;Clinical Research;cohort;Collection;Communication;Communities;community engaged research;Complement;Complex;Cone;Consolidated Framework for Implementation Research;COVID-19;Custom;Data;design;Devices;Disease;Early identification;Engineering;Enrollment;Evaluation;experience;Feedback;Fibrosis;Flare;Foundations;fungus;Future;Gene Expression Profile;Genetic Transcription;Goals;Grant;Guidelines;health care availability;Healthcare;Healthcare Systems;Home;Human;Immune response;implementation science;improved;In Vitro;Individual;Infection;Inflammation;Inflammatory;insight;Interview;laboratory experience;Left;Longitudinal Studies;Mediating;Medical center;Methodology;Methods;Microbe;microbial;Microfluidics;Molecular;nasal swab;novel;Paracrine Communication;parent project;Parents;Participant;pathogen;Persons;Population;Population Heterogeneity;Positioning Attribute;Post-Acute Sequelae of SARS-CoV-2 Infection;Preparation;Process;Production;Publishing;recruit;Research;Research Design;Research Personnel;research study;RNA;Role;sample collection;Sampling;SARS-CoV-2 infection;Shapes;Signal Pathway;Signal Transduction;Signaling Molecule;Signaling Protein;small molecule;Stabilizing Agents;Structure;success;Suggestion;Surveys;Symptoms;System;telehealth;Telemedicine;Time;tool;transcriptome sequencing;transcriptomics;treatment response;Tube;United States National Institutes of Health;Universities;usability;validation studies;Vasodilation;Visit;Vocabulary;volatile organic compound;Volatilization;willingness;Woman;Work

PROJECT_TITLE: Deciphering the role of chemical signals in inflammation with open microfluidic functional assays - U3 Supplement

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE No change from original award.

PI_NAMEs: PAQUETTE, ERIN D (contact)

PROGRAM_OFFICER_NAME: JENKINS, TAMMARA L

PROJECT_TERMS: Acute;Administrative Supplement;Area;Award;Child;Childhood;Consensus;Critical Care;Data;Data Analyses;data management;Development;Disparity;Emergency Care;Enrollment;experience;Exploratory/Developmental Grant;Funding;Goals;Grant;health disparity;insight;Intervention;Intervention Studies;Interview;Literature;Manuscripts;member;Mentored Patient-Oriented Research Career Development Award;Mentorship;Methods;multi-site trial;Parents;pediatric emergency;Physicians;Productivity;prospective;Qualitative Methods;Recovery;recruit;Research;Research Personnel;Risk;Surveys;Testing;Training Support;Writing

PROJECT_TITLE: ADaPT to Engage: Assessing for Disparities and Potential Targets for Intervention to Engage Acutely Ill Children in Research


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Machine Learning and Artificial Intelligence;Nanotechnology;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: GREENSBORO

ORG_NAME: NORTH CAROLINA AGRI & TECH ST UNIV

PHR: NERVE, a pioneering biomedical engineering center, aims to advance mini-brain technology and drug delivery system through cutting-edge research, imaging and animal testing capacity building, PhD program establishment, and the cultivation of a diverse workforce, transforming the field for the next generation.

PI_NAMEs: YUN, YEOHEUNG  (contact)

PROJECT_TERMS: Administrator;Affect;Alcohol abuse;Alzheimer's Disease;Animal Testing;Animals;Biocompatible Materials;Biology;Biomedical Engineering;biomedical imaging;Blood - brain barrier anatomy;Brain;Brain Diseases;brain health;Collaborations;Contrast Media;course development;design;Diagnosis;Disease;disease model;Diverse Workforce;Doctor of Philosophy;Drug Delivery Systems;Ecosystem;Education;Electrical Engineering;Emerging Technologies;Engineering;Epilepsy;Ethics;Evaluation;Extracellular Matrix;Family;Feedback;Fostering;Future;Goals;High Prevalence;high throughput screening;Historically Black Colleges and Universities;Hospitals;Human;human induced pluripotent stem cells;Image;Imaging technology;improved;in vitro Model;in vivo;Individual;Industry;innovation;innovative technologies;Institution;Lead;Lighting;Machine Learning;Mental disorders;Microfluidics;Microscope;Modeling;multidisciplinary;Mus;nanodevice;nanomaterials;nanoparticle;Nervous System Disorder;Neurologist;Neurosciences;neurovascular;new technology;next generation;organoid transplantation;Organoids;Parkinson Disease;Pharmaceutical Preparations;Population;Positioning Attribute;Prevalence;prevent;Prevention;Process;Program Development;programs;Psychologist;Psychology;Qualifying;Regenerative Medicine;Research;Science;Scientist;skills;Societies;stem cells;System;Techniques;Technology;Tissue Engineering;Translating;Transplantation;Transportation;Underrepresented Populations;Universities;Validation;Vascularization;Washington;Workforce Development

PROJECT_TITLE: Center for Neurovascular Engineering Research and adVanced Education (NERVE)


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Precision Medicine;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PI_NAMEs: BASFORD, MELISSA ;GLAZER, DAVID ;HARRIS, PAUL A. (contact);PHILIPPAKIS, ANTHONY ;RODEN, DAN M

PROGRAM_OFFICER_NAME: AZUINE, ROMULADUS EMEKA

PROJECT_TERMS: All of Us Research Program;Data;data infrastructure;Disease;Goals;Health;prevent;Research;Research Personnel;Vision

PROJECT_TITLE: All of Us Research Program Data and Research Center


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because cell division is a fundamental process of broad importance, yet the mechanisms underlying how cells grow and elongate in highly confining microenvironments for cell division are unclear. Therefore, the proposed research on understanding of the force-based mechanisms of cell division in highly confining microenvironments, via combined experimental and computational approaches, is relevant to part of NIH’s mission that seeks to develop fundamental knowledge that will help reduce the burdens of human disability and disease. Ultimately, it is anticipated that this study will uncover new insights and provide a new perspective on cell division, which will contribute to our understanding of processes in development, homeostasis, regeneration, and disease, and will also potentially lead to new therapies.

PI_NAMEs: KIM, TAEYOON  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: 3-Dimensional;Adult;Alginates;Automobile Driving;Behavior;Biocompatible Materials;Biological Process;Cell Culture Techniques;Cell Cycle;Cell division;cell growth;Cell Line;Cell membrane;Cell Mobility;cell osmotic pressure;Cell Separation;cell type;Cell-Matrix Junction;Cells;Characteristics;Collagen;Complex;Computer Models;CRISPR/Cas technology;Cultured Cells;defined contribution;Development;disability;Disease;Elasticity;Engineering;Experimental Models;experimental study;extracellular;Extracellular Matrix;Feedback;force feedback;G1 Phase;Generations;Goals;Growth;Homeostasis;Human;human embryonic development;innovation;insight;Ion Channel;Knock-out;Knowledge;Location;Malignant Neoplasms;Mammalian Cell;Measurement;Mechanics;Mediating;Mission;Mitosis;Mitotic;Modeling;Morphology;Movement;Myosin ATPase;Natural regeneration;novel;novel therapeutics;Osmotic Pressure;Physical Examination;Physiological;Process;Property;Public Health;regenerative;Relaxation;Research;Research Project Grants;Role;spheroids;Stress;Testing;three dimensional cell culture;tumor;United States National Institutes of Health;viscoelasticity;wound healing

PROJECT_TITLE: Mitosis in Confining Microenvironments