ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Primary Health Care;Substance Misuse

ORG_DEPT: PSYCHIATRY

PHR: Project narrative Due to the national opioid death epidemic and serious OUD physician shortages, this proposed study of identifying implementation barriers/facilitators of establishing pharmacy methadone medication units (MUs) is timely needed. We will produce multiple publications and an electronic implementation toolkit for establishing MUs to quickly disseminate the toolkit and publications to OTP directors and pharmacists nationally through the help of our consultants. The content of the toolkit will use the well-established Canadian model of pharmacy MUs as a framework and specify applicable information of WHAT, WHO, WHERE, WHEN, and HOW instructions for each element of standards of care of MU based on study findings and allowed US federal regulations to help pharmacists and OTP directors establish and practice MUs.

PI_NAMEs: WU, LI-TZY  (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: Address;Admission activity;Agreement;American;Area;Buprenorphine;buprenorphine treatment;Burn injury;Canada;Caring;Certification;collaborative care;Communities;community engagement;Community Pharmacy;Community Physician;Community Surveys;contextual factors;cost effective;Country;Data;design;drug testing;Electronics;Elements;Enrollment;Epidemic;experience;follow-up;Geography;Health Professional;Health Services Accessibility;implementation barriers;implementation facilitators;Improve Access;Individual;Instruction;Interview;Licensing;Location;Maintenance;medication for opioid use disorder;Methadone;methadone treatment;Methods;Modeling;Morbidity - disease rate;nonmetropolitan area;Opioid;opioid epidemic;opioid mortality;opioid treatment program;opioid use disorder;Parents;Participant;Patient Care;Patients;Peer Review;Perception;Persons;Pharmaceutical Preparations;Pharmacists;Pharmacy Administration;Pharmacy facility;Physicians;Primary Care Physician;Provider;Publications;Publishing;Regulation;Research;Research Design;retention rate;Rural;rural area;Sampling;Site;Specific qualifier value;suburb;Surveys;Time;Travel;Trust;United States Substance Abuse and Mental Health Services Administration;willingness;young adult

PROJECT_TITLE: Increasing access to opioid use disorder treatment by opening pharmacy-based medication units of opioid treatment programs

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: SAINT LOUIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_FIPS: US

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Our research has shown that uptake of our new PET radiotracer, 64Cu-CANF-Comb, in carotid atherosclerotic lesions in patients with asymptomatic carotid artery stenosis who underwent carotid endarterectomy (CEA) surgery correlates with features of high-risk plaque in ex vivo CEA specimens collected from these patients. Additionally, preliminary retrospective assessment of outcomes in asymptomatic carotid artery stenosis patients who did not go on to surgery showed higher PET uptake of radiotracer in patients who later had ischemic cerebrovascular events than in patients who did not. In this proposal, we further explore the potential of this PET radiotracer to stratify asymptomatic carotid artery stenosis patients, identifying patients with ‘higher-risk’ atherosclerosis who would most benefit from surgery.

PI_NAMEs: WOODARD, PAMELA K (contact);ZAYED, MOHAMED A.

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Aftercare;Anatomy;Arterial Fatty Streak;atherosclerosis risk;Biology;Blood Platelets;Blood Vessels;C-Type Natriuretic Peptide;Carotid Artery Plaques;Carotid Atherosclerotic Disease;Carotid Endarterectomy;Carotid Stenosis;Cell Lineage;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;cerebrovascular;chelation;Clinical;cohort;Complex;Consensus;Data;Detection;diabetes management;Diameter;differential expression;Disease;Endothelium;Event;Evolution;first-in-human;fluorodeoxyglucose;Funding;G-Protein-Coupled Receptors;Gene Expression;Goals;Grant;Guidelines;Health Care Costs;high risk;Human;human study;Hyperplasia;Hypertension;hypertension control;Image;imaging approach;Imaging Techniques;Immunohistochemistry;immunoregulation;Individual;Infiltration;Inflammation;Intervention;Interview;Ipsilateral;Ischemia;Ischemic Stroke;Length;Ligands;Macrophage;Magnetic Resonance Imaging;Medical;Molecular;molecular imaging;Morphology;nanoparticle;Natriuretic Peptides;novel;Observational Study;Operative Surgical Procedures;Outcome Assessment;Outcome Study;patient stratification;Patient-Focused Outcomes;Patients;Peptide Receptor;Perioperative;Physiological;Positron-Emission Tomography;Predictive Value;radiotracer;receptor;Recommendation;Regulation;Research;Risk;Risk Marker;risk stratification;RNA;Role;routine screening;Rupture;Shapes;Signal Transduction;Smooth Muscle Myocytes;Specimen;stroke risk;Surgeon;Symptoms;Telephone;Testing;Tracer;transcriptomics;United States;United States National Institutes of Health;Universities;uptake;Vascular remodeling;Vascular Smooth Muscle;vascular smooth muscle cell proliferation;Washington;Work;X-Ray Computed Tomography

PROJECT_TITLE: A Receptor-Targeted Nanoparticle PET Tracer in Human Carotid Atherosclerosis

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Biotechnology;Drug Abuse (NIDA only);Gene Therapy;Genetics;HIV/AIDS;Immunotherapy;Infectious Diseases;Substance Misuse

ORG_CITY: ATLANTA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Although the use of antiretroviral therapy (ART) has allowed people living with HIV to live without detectable virus, ART alone is not sufficient for reducing the viral reservoir. Adeno-associated virus (AAV) vectors can provide long-term expression of HIV-1 broadly neutralizing antibodies (bNAbs) and HIV-1 inhibitors, which could potentially replace or used in combination with daily administration of ART to reduce the viral reservoir. Here we propose novel AAV gene therapy technologies to suppress an established SHIV infection in rhesus macaques in place of ART, evaluate the rate of the viral reservoir decay, and improve the safety of AAV vectors.

PI_NAMEs: GARDNER, MATTHEW RYAN (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: adeno-associated viral vector;adenovirus mediated delivery;Anti-Retroviral Agents;Antibodies;Antibody Response;antiretroviral therapy;Binding Sites;Clinical Trials;cohort;Data;Dependovirus;design;Dose;Engineering;Evaluation;gene therapy;HIV;HIV Entry Inhibitors;HIV-1;HIV-2;Human;humanized mouse;immune checkpoint;Immune response;Immune system;Immune Targeting;improved;In Vitro;in vivo;Individual;Infection;Infusion procedures;inhibitor;Injecting drug user;Intramuscular;Lifting;Macaca;Macaca mulatta;Mediating;men;Monkeys;Mus;Muscle;Muscle Cells;Needle Sharing;neutralizing antibody;novel;Pathway interactions;Persons;Pharmaceutical Preparations;Pharmacotherapy;Pilot Projects;programmed cell death ligand 1;Proteins;receptor binding;Reporting;Resistance;Safety;Serum;simian human immunodeficiency virus;SIV;Skeletal Muscle;small molecule;success;Technology;Testing;Therapeutic;therapy development;Time;Tissues;transgene expression;Transgenes;transmission process;Treatment Efficacy;United States;Viral;viral DNA;Viral Load result;viral rebound;Viral reservoir;viral RNA;Viremia;Virus;Virus Replication;Virus-like particle;Woman

PROJECT_TITLE: AAV-delivered HIV inhibitors for SHIV therapy


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Columbus

ORG_DEPT: GENETICS

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Retroviruses must integrate into their host genome and cause a variety of devastating diseases including AIDS and leukemia. Integration into the host genome is catalyzed by a complex of the viral integrase protein with the viral copy DNA (termed an intasome), which assemble with a variable number of integrase subunits depending on the retrovirus. The goal of this proposal is to utilize advanced single molecule imaging technologies and well- defined retrovirus models with different integrase multimeric architecture to quantitatively determine the rules for intasome assembly, stability, and host genome capture-integration mechanics.

PI_NAMEs: FISHEL, RICHARD ;YODER, KRISTINE E (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;Architecture;Binding;Biochemical;biophysical model;biophysical properties;Biophysics;C-terminal;Catalytic Domain;cellular transduction;Chromatin;Chromosomes;Complementary DNA;Complex;Costs and Benefits;dimer;Disease;DNA;DNA Binding;DNA lesion;DNA Repair;Exhibits;Experimental Models;Family;feature detection;flexibility;Genome;genomic RNA;Genomics;Goals;Histones;HIV-1;Imaging Device;imaging platform;Imaging technology;In Vitro;in vivo;Infection;innovation;Integrase;integration site;Kinetics;Knowledge;Length;Lentivirus;Lesion;leukemia;Link;Long Terminal Repeats;mammary tumor virus;Mechanics;Modeling;Mouse Mammary Tumor Virus;N-terminal;Nucleosomes;obligate intracellular parasite;Peptides;Post-Translational Protein Processing;Process;Productivity;Proteins;Protocols documentation;Protomer;prototype;Publishing;Reporting;Retroviridae;Retrovirology;Reverse Transcription;Role;Rous sarcoma virus;single molecule;Site;Spumavirus;Structure;Tail;Testing;therapeutic target;Time;tool;transforming virus;Viral;viral DNA;Viral Genome;Virion;Virus Assembly;Visna-maedi virus;Work

PROJECT_TITLE: Determinants of Architecture on Retroviral Intasome Mechanics

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


ADMINISTERING_IC: TR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Arthritis;Asthma;Bioengineering;Clinical Research;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric

ORG_CITY: DAVIS

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Project Narrative As the medical field evolves in the 21st century, there is a growing understanding that minimally invasive diagnostic tools will be increasingly useful to diagnose or monitor a wide variety of diseases. This project will deploy and test skin volatile organic compound (VOC) detector systems in both hand-held and wearable formats for 20 diseases at two clinical testing sites. When coupled with other non-invasive vital sign sensors, these integrated data streams will be interpreted using artificial intelligence algorithms for real-time diagnostics.

PI_NAMEs: DAVIS, CRISTINA ELIZABETH (contact);KENYON, NICHOLAS J.

PROGRAM_OFFICER_NAME: CROUCHER, LEAH TOLOSA

PROJECT_TERMS: Adult;Aerospace Engineering;Algorithms;Artificial Intelligence;artificial intelligence algorithm;Asthma;asthmatic patient;Attention deficit hyperactivity disorder;autism spectrum disorder;Automatic Data Processing;Benchmarking;biomarker discovery;Biomedical Technology;Blood Pressure;California;Catalogs;Chemicals;Childhood;Chronic Disease;Chronic Obstructive Pulmonary Disease;Clinical;Clinical Management;clinical research site;cohort;commercialization;Connective Tissue Diseases;cost;Coupled;Data;Data Analyses;data integration;data streams;Degenerative polyarthritis;Detection;detector;Development;Devices;Diagnosis;Diagnostic;Diagnostic tests;diagnostic tool;Differential Diagnosis;Disease;disease diagnosis;Disease Management;Eczema;Engineering;Enterovirus Infections;Environment;Exhalation;Fever;Fingerprint;Flare;Fragile X Premutation;Funding;Galvanic Skin Response;Gases;Goals;graphical user interface;Health;health care settings;Healthcare;Heart Rate;Home;Humidity;Hypersensitivity skin testing;improved;Individual;influenza infection;instrument;Joints;Knowledge;Lead;Link;Lung;Lung Diseases;Machine Learning;machine learning algorithm;manufacture;Mass Spectrum Analysis;Measurement;Measures;Mechanics;Medical;Mental Health;metabolomics;Methods;mHealth;minimally invasive;Monitor;National Institute of Biomedical Imaging and Bioengineering;National Institute of Environmental Health Sciences;novel;novel diagnostics;Output;Oxygen;Patients;Pattern;Pediatric Hospitals;pediatric patients;Phase;Philadelphia;point-of-care diagnostics;portability;power consumption;programs;Psoriasis;Psoriatic Arthritis;Publishing;Pulmonary Embolism;Pulmonary Fibrosis;Pulmonary Hypertension;Pulse Rates;RADx Radical;Rapid diagnostics;Reagent;real time monitoring;Regulatory Pathway;research clinical testing;Respiration;Respiratory Signs and Symptoms;Respiratory Syncytial Virus Infections;Rheumatoid Arthritis;Sampling;Sarcoidosis;Schizophrenia;sensor;Sickle Cell Anemia;Site;Skin;skin disorder;Skin Temperature;Spectrometry;Standardization;Symptoms;System;Systemic disease;telehealth;Testing;Time;tool;Training;United States National Institutes of Health;Urinary tract infection;Urine;Virus Diseases;volatile organic compound;Vulnerable Populations;wearable device;wearable sensor technology;Weight;Work

PROJECT_TITLE: Monitoring of disease-induced skin VOC patterns from handheld and wearable chemical sensors


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Patient Safety;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Major challenges exist for including genomic information broadly into clinical risk assessment in diverse and multi-ethnic populations, and issues of bias in research databases, community engagement, and access to leading-edge digital technology disproportionately impact underserved populations. We will recruit 2,500 ethnically diverse and medically underserved NYC patients into a clinical trial to estimate individualized disease risk and investigate the impact of genomic risk communication to patients and their physicians, including trust and understanding of the information, uptake of recommended interventions, and psychosocial outcomes. We will work closely with our NHGRI, eMERGE, community, industry, and health system partners, and use lessons learned to inform future research and clinical strategies, maximize efficiency for genomic medicine delivery, and promote health equity.

PI_NAMEs: ABUL-HUSN, NOURA SERENE;KENNY, EIMEAR ELIZABETH (contact)

PROGRAM_OFFICER_NAME: ROWLEY, ROBB KENNETH

PROJECT_TERMS: Address;Adult;Artificial Intelligence;Attitude;behavioral outcome;Benchmarking;biobank;Calibration;Caring;Clinic;Clinical;clinical care;Clinical Data;clinical decision-making;clinical research site;clinical risk;Clinical Trials;cohort;Collaborations;Communication;Communities;community engagement;Complex;Computer software;Data;data resource;Databases;design;Development;digital health;digital platform;digital technology;Disease;disorder risk;ethnic diversity;Ethnic Population;European ancestry;experience;Family;flexibility;Genetic;Genomic approach;Genomic medicine;Genomics;Health;health application;health disparity;health equity;health equity promotion;health literacy;Health system;Healthcare Systems;high risk;implementation barriers;improved;Individual;Industry;industry partner;Inequity;innovation;Institution;interdisciplinary collaboration;Intervention;Investments;Knowledge;Learning;Life;Link;mathematical ability;medically underserved;member;Methods;Mission;multi-ethnic;Multilingualism;National Human Genome Research Institute;New York City;Outcome;Participant;Patient Care;Patient Education;patient engagement;patient population;Patient Self-Report;Patients;pediatric patients;Perception;Phase;Physicians;polygenic risk score;Population;Population Genetics;Population Heterogeneity;Predictive Value;preference;primary care practice;psychological outcomes;psychosocial outcome;Qualitative Research;racial population;Recommendation;Recording of previous events;recruit;Reporting;Research;Research Personnel;Risk;Risk Assessment;risk prediction;Risk Reduction;risk stratification;Role;Science;Scientist;Social outcome;Speed;Technology;Testing;tool;Trust;Underserved Population;uptake;Urban Health;Work

PROJECT_TITLE: Genomic risk in clinic care to promote health equity in New York City patients


NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative: Metabolic flexibility is essential for cellular and organismal survival in times of energetic stress. Our work aims to decipher the molecular pathways that enable energetic cells like neurons to fine-tune their metabolic programs to energy demand and thereby perform highly complex functions.

PI_NAMEs: ASHRAFI, GHAZALEH  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Bioenergetics;Biosensor;Cell Energetics;Cell Physiology;cell type;Cells;cellular imaging;Communities;Complex;Coupled;Diabetes Mellitus;Disease;Endocytosis;Energy Metabolism;Eukaryotic Cell;flexibility;Gene Expression Profile;Genomics;Glycolysis;Goals;Laboratories;Leigh Disease;Metabolic;Metabolic dysfunction;metabolic imaging;Metabolism;Mitochondria;Molecular;Muscle Fibers;Myopathy;Neurons;new technology;novel;optical imaging;Oxidative Phosphorylation;Pathway interactions;Process;Production;programs;Regulation;Research;Stress;Synaptic Vesicles;tool;transcriptomics;Work

PROJECT_TITLE: Cellular mechanisms of bioenergetic plasticity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Disability Research;Networking and Information Technology R&D (NITRD);Neurosciences;Osteoarthritis;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Precision Medicine;Rehabilitation;Stroke;Traumatic Head and Spine Injury

ORG_CITY: HOUSTON

ORG_NAME: RICE UNIVERSITY

ORG_STATE: TX

PHR: Project Narrative This project seeks to develop computer software that will improve the design of treatments for movement impairments caused by conditions such as stroke, osteoarthritis, spinal cord injury, orthopedic cancer, and limb amputation. The proposed software would take advantage of the same computer simulation technologies that have revolutionalized the design of airplanes and automobiles. The software would allow researchers to build a virtual model of the patient and then systematically test various treatments scenarios in the computer to identify the most promising treatment option, and how to implement it, for the patient.

PI_NAMEs: FREGLY, BENJAMIN J (contact);PATTEN, CAROLYNN

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: Acceleration;Address;Adoption;Adult;Affect;Aftercare;American;Amputation;Anatomy;Applications Grants;Automobiles;Biomechanics;Biomedical Engineering;Calibration;Cerebral Palsy;Clinical;clinical practice;Collaborations;Communities;Computer Models;computer scientist;Computer Simulation;Computer software;Computers;cost;Data;Data Set;Degenerative polyarthritis;design;Development;Devices;Diabetes Mellitus;Doctor of Philosophy;Engineering;Evaluation;evidence base;exoskeleton;flexibility;foot;functional outcomes;Funding;Generations;Goals;graphical user interface;Health;Healthcare;Heart Diseases;Human;Impairment;Implant;improved;Individual;innovation;interdisciplinary approach;Intervention;Joints;Judgment;Laws;Learning;limb amputation;Long term disability;Malignant Neoplasms;Metabolic;Methods;model development;Modeling;models and simulation;motor impairment;Movement;Muscle;Musculoskeletal;neuromusculoskeletal;neuroregulation;Operative Surgical Procedures;Orthopedics;Parkinson Disease;Participant;Patients;personalized intervention;personalized medicine;physical therapist;Physics;Physiology;Population;post stroke;prevent;Process;Productivity;prototype;Quality of life;Recovery;Rehabilitation therapy;Research;Research Personnel;Research Project Grants;Risk;Series;skeletal;societal costs;Societies;software development;Software Tools;Speed;Spinal cord injury;Stroke;Structure;Study Subject;symposium;Technology;Testing;therapy design;tool;Traumatic Brain Injury;treadmill training;treatment optimization;United States National Institutes of Health;virtual;virtual model;virtual patient;virtual therapy;Walking

PROJECT_TITLE: OpenSim Enhancements to Enable Computational Design of Personalized Treatments for Movement Impairments

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Genetics;Mental Health;Neurosciences;Schizophrenia;Serious Mental Illness;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Rare variants in SETD1A are associated with dramatically increased risk for schizophrenia, but the clinical phenotype and cellular mechanisms are poorly understood. We will investigate cognitive and psychiatric symptom phenotypes for carriers of SETD1A variants enriched in a founder population, the Old Order Amish. We will study pluripotent stem cells derived form a subset of these individuals to characterize variant  cell  brain  disease mechanisms.

PI_NAMEs: AMENT, SETH ABRAMS (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Affect;Alleles;Amish;Behavioral;Blood;Brain;brain cell;Brain Diseases;Cell Cycle;Cell Proliferation;Cells;Characteristics;ChIP-seq;Chromatin;chromatin modification;clinical heterogeneity;clinical phenotype;Cognition;Cognitive;Cognitive deficits;cohort;Complex;Data;Dependence;Development;developmental disease;Disease;DNA Damage;Dose;Enzymes;epigenetic therapy;exome sequencing;experimental study;Founder Generation;Gene Expression Profile;Gene Expression Regulation;Gene Frequency;Genes;Genetic Transcription;genome editing;Heterogeneity;Heterozygote;high risk;histone modification;Histones;Human;human embryonic stem cell line;in vivo;Individual;induced pluripotent stem cell;insight;Lysine;Mediating;Methylation;Modeling;Molecular;Multiomic Data;multiple omics;nerve stem cell;network models;neural;Neurites;Neurobehavioral Manifestations;Neurobiology;neurodevelopment;Neurons;novel therapeutics;pharmacologic;Phenotype;Pluripotent Stem Cells;Population;premature;promoter;Protein Truncation;psychiatric symptom;psychosis risk;Public Health;public health relevance;rare variant;recruit;Resources;response;Risk;risk variant;RNA;Schizophrenia;schizophrenia risk;SET Domain;Severities;Tail;Techniques;Technology;Testing;Time;United States;Variant;Work;XCL1 gene

PROJECT_TITLE: Multi-scale consequences of variants in the schizophrenia risk gene SETD1A in a population isolate.

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: PROJECT NARRATIVE Glaucoma is a group of diseases that damage retinal ganglion cells, and can lead to irreversible blindness if left untreated, and as the world's population ages, it has been estimated that the global prevalence of glaucoma will reach at least 111 million individuals by 2040. While reduction of intraocular pressure can slow disease progression, patients with low pressure can progress to blindness. In this project, we will determine if non- invasive measures of the eyes vascular and how it responds to changes in intraocular pressure are determinant factors for glaucoma progression.

PI_NAMEs: PATEL, NIMESH BHIKHU (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: 3-Dimensional;adaptive optics scanning laser ophthalmoscopy;Age;Anatomy;Angiography;Animals;anterior chamber;Autopsy;Basement membrane;Blindness;Blood capillaries;Blood flow;Blood Vessels;Cannulations;Cell Density;Clinical;comparative;Data;Data Set;density;Disease;Disease Progression;disorder risk;Endothelial Cells;Euthanasia;experimental analysis;Experimental Models;experimental study;Exposure to;Eye;Eye diseases;Face;Glaucoma;Health;high risk;Histologic;Human;human subject;Image;Immunohistochemistry;in vivo;Individual;Individual Differences;innovation;Left;macula;Measures;Metabolic;Methods;Modeling;Monitor;Nature;neural;nonhuman primate;Optic Disk;optic nerve disorder;Optical Coherence Tomography;Papillary;Pathologic;Pathology;Patients;Perfusion;perfusion imaging;Pericytes;Perimetry;Physiologic Intraocular Pressure;Population;pressure;Prevalence;Process;Property;Radial;reconstruction;regional difference;Regulation;response;Retina;retinal damage;Retinal Ganglion Cells;retinal nerve fiber layer;Risk;Risk Factors;Scanning;Scanning Electron Microscopy;Structure;Technology;Testing;Thick;Thinness;Time;Tissues;Transmission Electron Microscopy;Vascular blood supply;vascular factor;Vision

PROJECT_TITLE: OCTA and Glaucoma Progression in the Non-Human Primate

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative: Through this Avant-Garde Award, I plan to fill in the gaps of the United States Ending the HIV Plan for persons who use drugs (PWUD). My pioneer award vision is to develop a mobile hub and spoke model that has mobile pharmacies and clinics on wheels that deploy a rapid response sustainable workforce of trained community health workers and pharmacists that literally meet the community where they live. They will provide rapid HIV testing, opioid use disorder (OUD) diagnosis, same day deployment of medication treatment for OUD, PrEP and ART, and retain them on treatment where they live to advance the goal of ending HIV in PWUD.

PI_NAMEs: SPRINGER, SANDRA ANN (contact)

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: addiction;Address;Affect;antiretroviral therapy;Award;career;Caring;Clinic;Clinical;clinical care;Clinical Research;Collaborations;Communicable Diseases;Communities;Community Health Aides;Diagnosis;Diagnostic Services;Disease Outbreaks;Drug usage;Drug user;Ensure;Epidemic;epidemic preparedness;evidence base;experience;Fentanyl;Goals;Health Services Accessibility;HIV;HIV Infections;Hour;Human immunodeficiency virus test;Immigrant;Justice;Medicine;member;Methods;Modeling;opioid use disorder;Overdose;overdose death;Persons;Pharmaceutical Preparations;Pharmacists;Pharmacy facility;Physicians;pre-exposure prophylaxis;Prevention;prevention service;rapid diagnosis;Research;Research Personnel;response;Retinal blind spot;Risk;Services;Stimulant;Substance Use Disorder;Test Result;Testing;testing services;Time;Training;treatment planning;treatment services;Underrepresented Minority;Uninsured;United States;Vision;Woman;Work Ethic

PROJECT_TITLE: Ending HIV: Bringing Integrated Prevention and Treatment Services to People Who Use Drugs Where They Live


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: CLEVELAND

ORG_DEPT: PATHOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE Mitochondrial dysfunction is one of many prominent features of Alzheimer’s disease. Abnormal crosstalk between mitochondria and other cellular organelles were shown to play critical role in AD pathogenesis. The current application focuses on such abnormal inter-organelle crosstalk in AD neurons, which will provide novel mechanistic insights in AD pathogenesis and likely produce novel therapeutic targets for AD.

PI_NAMEs: WANG, WENZHANG  (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: abeta accumulation;abeta toxicity;Affect;aging population;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-Protein;Apolipoprotein E;apolipoprotein E-4;Biochemical;Brain;Cell model;Cholesterol;cholesterol trafficking;Cognitive;cohort;Data;disorder control;E protein;Endocytosis;Endosomes;Event;extracellular;Goals;hippocampal pyramidal neuron;Hippocampus;Homeostasis;Human;Immunofluorescence Immunologic;In Vitro;in vitro Model;in vivo;insight;interest;Investigation;knock-down;Knock-in;Late Onset Alzheimer Disease;Maintenance;Mediating;Mediator;Membrane Proteins;Mitochondria;mitochondrial dysfunction;Modeling;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;Neuronal Dysfunction;Neurons;new therapeutic target;novel;Organelles;Outcome;Outer Mitochondrial Membrane;Pathogenesis;Pathologic;Pilot Projects;Play;Population;Predisposition;Protein Isoforms;Protein Secretion;Proteins;receptor;Risk;Risk Factors;Role;Surface;System;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Toxic effect;Transgenic Mice;translational potential;Vesicle

PROJECT_TITLE: Abnormal mitochondrial-endolysosomal contacts in AD

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research;Hematology;Infectious Diseases;Pediatric;Rare Diseases;Sickle Cell Disease

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE The clinical implications of B cell deficiency in SCD are not fully understood and requires investigating both the clinical implications and the mechanism of B cell deficiency. The rationale underlying this proposal is that assessment of B cell development and survival in SCD may enable risk assessment or reduction of infections. By understanding B cell deficiency in SCD, we can reduce the infection-related morbidity and mortality in SCD.

PI_NAMEs: TUBMAN, VENEE N (contact)

PROGRAM_OFFICER_NAME: LOUDEN, ANDREW

PROJECT_TERMS: 5 year old;Abnormal Cell;Acute;Africa;Africa South of the Sahara;Age;ANXA5 gene;Apoptosis;B cell differentiation;B-Cell Development;B-Lymphocyte Subsets;B-Lymphocytes;Bacteremia;BCL2 gene;biomarker development;CASP3 gene;Cessation of life;Chest;Child;Childhood;Clinical;clinical phenotype;Coculture Techniques;cohort;Custom;cytokine;Cytokine Signaling;Development;Disease;driver mutation;Enrollment;Environment;Enzyme-Linked Immunosorbent Assay;experience;Exposure to;Funding;Goals;Histopathology;Human Herpesvirus 4;humoral immunity deficiency;Immune;immune function;Immune response;Immune system;Impairment;In Vitro;infancy;Infection;infection risk;Inflammatory;inflammatory milieu;Innate Immune Response;insight;Intrinsic factor;Investigation;Kinetics;Life;Lymphocyte Count;Malaria;Marginal Zone B-Lymphocyte;Measures;Memory B-Lymphocyte;Mentorship;Modeling;Monitor;Morbidity - disease rate;mortality;Natural Immunity;new therapeutic target;Osteomyelitis;pathogen;patient stratification;Patients;peripheral blood;Plasma Cells;Plasmodium;Population;programs;Proliferating;Research;Research Personnel;Risk Assessment;Risk Reduction;risk stratification;Role;sample collection;Sampling;Serum;Sickle Cell Anemia;Spleen;System;T-Lymphocyte;Tanzania;Texas;Therapeutic;therapeutic biomarker;therapeutic target;Tissue Banks;Tissues;tool;Training;Viral;Virus;Work

PROJECT_TITLE: Characterization of B Lymphocyte Deficiency in Pediatric Sickle Cell Disease


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Neurofibromatosis;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Heart failure remains a leading global health and economic burden, yet current therapies to treat heart failure are largely ineffective, likely due to late-stage disease intervention. We aim to elucidate molecular mechanisms that occur earlier and drive disease progression in order to identify new therapeutic candidates to improve clinical outcomes. In this proposal, we will investigate the transcriptional regulation of metabolic dysfunction and resulting energy insufficiency that is known to contribute to heart failure.

PI_NAMEs: DEL RE, DOMINIC P (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: Acute;Affect;autosome;Binding;Biopsy;candidate identification;Cardiac;Cardiac Myocytes;cell growth;Cell Respiration;Central Nervous System Neoplasms;Chronic;Chronic stress;Clinical;Coupling;Data;Development;Disease;Disease Progression;Down-Regulation;Economic Burden;estrogen-related receptor;Evaluation;Event;experimental study;Failure;flexibility;Gene Expression;Generations;Genes;Genetic Transcription;genome-wide;global health;Heart;Heart failure;Homeostasis;Human;Impairment;improved;in vivo;Intervention;Ischemia;Lead;Link;loss of function mutation;Mediating;Mediator;Metabolic;Metabolic dysfunction;Metabolic Pathway;Metabolism;Mitochondria;Modeling;Molecular;Mus;Myocardial;Myocardial dysfunction;Neurofibromatosis 2;Neurofibromin 2;novel;novel therapeutic intervention;novel therapeutics;Organ;Outcome;Oxidation-Reduction;Oxidative Phosphorylation;Pathogenesis;Pathologic;Pathway interactions;Phase;pressure;prevent;Production;programs;Proliferating;Proteomics;Respiration;response;Role;Scaffolding Protein;Signal Pathway;Starvation;Stress;Testing;Therapeutic;therapeutic candidate;transcription factor;Transcriptional Regulation;transcriptomic profiling;Tumor Suppressor Proteins;Wild Type Mouse

PROJECT_TITLE: The role of Neurofibromin 2 in heart failure

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Successful completion of development requires tight control of gene expression. The research described in this proposal will examine the basic mechanisms that determine where and when the DNA regulatory elements controlling gene expression are used. Defects in gene regulation can endow cells with new properties that lead to disease; therefore, knowledge of the underlying mechanisms is important for human health.

PI_NAMEs: MCKAY, DANIEL J (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: 3-Dimensional;Adopted;Animal Model;Animals;Binding;Cell Differentiation process;Cells;Chromatin;Decision Making;Defect;Development;Developmental Gene;Disease;DNA;DNA Binding;DNA Sequence;Drosophila genus;Endowment;Enhancers;Epigenetic Process;Gatekeeping;Gene Activation;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic information;genetic resource;Genetic Transcription;Genome;Genotype;Grant;Health;histone modification;Histones;Human;Knowledge;Maintenance;Multipotent Stem Cells;mutant;Nucleosomes;Play;Post-Translational Protein Processing;prevent;Process;Property;Proteins;Regulatory Element;Research;Role;Switch Genes;Testing;Time;transcription factor;Transcriptional Regulation

PROJECT_TITLE: Genetic and epigenetic mechanisms of developmental gene regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Gene Therapy;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Nanotechnology;Regenerative Medicine

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE For patients with severe heart failure, therapeutic options are limited and cardiac transplantation is challenging due to shortage of donor hearts and high morbidity of the patients. We have developed an innovative approach that will address this unmet need using injectable biomaterials to deliver active molecules for cardiac repair.

PI_NAMEs: PENA CASTELLANOS, BRISA MARISOL (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Area;Atomic Force Microscopy;Award;Biocompatible Materials;Biological;Biology;biomaterial compatibility;Biomedical Engineering;Body Temperature;Carbon Nanotubes;Cardiac;cardiac regeneration;cardiac repair;cardiac tissue engineering;Cell Proliferation;Cellular biology;clinical application;delivery vehicle;Down-Regulation;Echocardiography;Evaluation;Exposure to;Fibroblasts;Fibrosis;Formulation;Funding Agency;Gel;Gene Expression;Generations;Genes;Genetic Transcription;Heart;Heart failure;heart function;Heart Transplantation;Histology;Homer 1;Human;Hydrogels;Immunohistochemistry;improved;in vivo;in vivo Model;Inflammation;Injectable;Injections;innovation;Investigation;Knowledge;Lipids;liposome vector;Liquid substance;Maps;Measurement;Measures;Mentors;Methods;microRNA delivery;MicroRNAs;Modeling;Morbidity - disease rate;mouse model;Mus;Myocardial;myocardial damage;Myocardial Infarction;Natural regeneration;Needles;novel;Operative Surgical Procedures;Optics;Pathway interactions;Patients;Positioning Attribute;Proliferating;regenerative;Safety;screening;second harmonic;Site;skills;Structure;System;targeted delivery;Technology;Testing;Therapeutic;Tissues;Toxic effect;Training;transcriptome;Transfection;Translating;Ultrasonography;Viral;Viral Vector

PROJECT_TITLE: Injectable Carbon Nanotube-Functionalized Hydrogel for miRNA Delivery

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(JA)]


ADMINISTERING_IC: HD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE  This project contributes to public health knowledge by building on the Michigan Contraceptive Access Research and Evaluation Study (M-CARES) to evaluate the long-term effects of mothers’ access to free contraceptives and reductions in unintended pregnancies on an understudied group: children. By providing a more comprehensive evaluation of the intergenerational benefits of subsidies for contraception in the U.S., this study informs the implications for changes in Title X funding under the Public Health Services Act.

PI_NAMEs: BAILEY, MARTHA JANE;LANG, VANESSA WANNER (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Adult;Age;Behavior;Birth;Birth Certificates;Birth Records;Career Mobility;Censuses;Child;Child Health;Child Rearing;Childhood;Clinic;college;Consent;Contraceptive Agents;Contraceptive methods;cost;Cost-Benefit Analysis;Criminal Justice;Data;data infrastructure;Dimensions;Disadvantaged;Education;Eligibility Determination;Employment;empowerment;Enrollment;Etiology;Evaluation;Evaluation Studies;experimental study;Facebook;Family;Family Planning;Family Planning Policy;Family Planning Programs;foster care;Funding;Health;Health Insurance;health knowledge;Health Policy;Health system;Healthcare;Heterogeneity;improved;Income;innovation;Instagram;intergenerational;Intervention;late life;Life;Link;Long-Term Effects;Medicaid;Michigan;Mothers;novel;Outcome;Parents;Participant;Personal Satisfaction;Planned Parenthood Federation of America;Policies;post intervention;Poverty;Principal Investigator;Privatization;Public Health;Public Policy;Quasi-experiment;Race;Randomized;Randomized, Controlled Trials;Recontacts;Records;recruit;Reporting;reproductive health intervention;Research;research study;Resources;Role;Running;Sample Size;Sampling;Schools;Siblings;social media;Social Sciences;Subgroup;Surveys;Taxes;Time;treatment effect;Twitter;Uninsured Medical Expense;unintended pregnancy;United States;United States Public Health Service;voucher;Woman

PROJECT_TITLE: The Effects of Unintended Pregnancy on Children

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: AR

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Clinical Research;Kidney Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Approximately 500,000 people in the United States have end-stage kidney disease and are receiving dialysis therapy. Impaired mobility and disability are important contributors to their high rates of morbidity and mortality. This proposal tests a novel approach to improving their care by systematically evaluating the effects of dialysis initiation on skeletal muscle fibrosis and physical function, based on the hypothesis that earlier initiation of dialysis in appropriate patients could improve outcomes by preventing physical function decline.

PI_NAMEs: ABRAMOWITZ, MATTHEW K (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Age;Biopsy;blood filtration;Caring;Cells;Chronic;Chronic Kidney Failure;clinical practice;clinically relevant;Collagen;crosslink;Data;Deposition;Development;Dialysis procedure;disability;End stage renal failure;experience;Extracellular Matrix;Fatty acid glycerol esters;Fibrosis;frailty;functional decline;Functional disorder;functional improvement;Goals;healthy volunteer;Homeostasis;Human;improved;improved outcome;innovation;Intervention;Kidney Diseases;Kidney Failure;Leg;Lower Extremity;Magnetic Resonance Imaging;Measures;Mechanics;Mediator;Methods;Mobility decline;Molecular;Morbidity - disease rate;mortality;Muscle;muscle progenitor cell;Muscle satellite cell;muscle strength;Muscular Atrophy;Nature;novel strategies;Outcome;Pathology;Patient-Focused Outcomes;Patients;Performance;Persons;Physical Function;Physical Performance;Physicians;predicting response;preservation;prevent;primary outcome;Process;proteomic signature;Proteomics;quadriceps muscle;Race;reduced muscle strength;Relaxation;Resolution;secondary outcome;Severities;sex;Skeletal Muscle;Symptoms;Testing;Time;Tissues;transcriptome sequencing;transcriptomics;Translating;translational approach;Translations;United States;Walking

PROJECT_TITLE: Preserving physical function in patients with kidney disease

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cardiovascular;Comparative Effectiveness Research;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Orphan Drug;Pediatric;Rare Diseases;Regenerative Medicine;Transplantation

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: PUBLIC HEALTH NARRATIVE Congenital cardiac anomalies represent the most common birth defect, affecting nearly 1% of all live births and despite significant advances in their surgical and medical management, these conditions remain a leading cause of death and disability in the newborn period. One significant source of morbidity and mortality arises from complications associated with the use of currently available prosthetic vascular grafts, cardiovascular patches, and replacement heart valves that are frequently required to perform reconstructive procedures. Tissue engineering offers a potential strategy for creating improved biomaterials for use in congenital heart surgery.

PI_NAMEs: BREUER, CHRISTOPHER KANE (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: 3-Dimensional;4D MRI;Acetylcholine;Adolescent;Affect;Age;Angiography;Animal Model;Animals;Autologous;Biocompatible Materials;Blood flow;Blood Vessel Prosthesis;Blood Vessels;calcification;Cardiac;Cardiovascular system;Caring;Cause of Death;Characteristics;Child;Cine Magnetic Resonance Imaging;Clinic;Clinical;Clinical Trials;cohort;Common Ventricle;comparative efficacy;Congenital Abnormality;congenital heart abnormality;Congenital Heart Surgery;Coupled;Data;design;Development;Devices;disability;Disease;Dobutamine;Dose;Electric Capacitance;Fontan Procedure;Functional Regeneration;Geometry;Goals;Grant;Growth;heart valve replacement;Heart Ventricle;hemodynamics;Image;Implant;implantation;improved;improved outcome;in vivo;Inferior vena cava structure;Investigation;life span;Liquid substance;Live Birth;Measures;Medical;Modeling;Monitor;Morbidity - disease rate;morphometry;mortality;Natural regeneration;Newborn Infant;Nitroglycerin;Norepinephrine;operation;Operative Surgical Procedures;Orphan;Performance;pharmacologic;Physiological;Polytetrafluoroethylene;Postoperative Complications;pre-clinical;preclinical study;pressure;prevent;Procedures;Property;Prosthesis;Public Health;Pulmonary artery structure;Reagent;Regulatory Pathway;repaired;Resistance;respiratory;response;Rest;Risk;Safety;scaffold;sex;Sheep;sheep model;Source;standard of care;Stress;Stress Tests;Technology;Testing;Time;Tissue Engineering;Tissues;Translating;ultrasound;Vascular Graft;vascular tissue engineering;vasoconstriction;Vasodilation;Ventricular Function;Work;X-Ray Computed Tomography

PROJECT_TITLE: A Preclinical Study Evaluating and Comparing the Efficacy of Tissue Engineered Vascular Grafts to Polytetrafluoroethylene Grafts

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: TALLAHASSEE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE This study will significantly contribute to the field of HIV prevention and treatment by testing an intervention that helps counseling and testing agencies contracted by Florida Department of Health to improve their services to young men who have sex with men.

PI_NAMEs: BAUERMEISTER, JOSE ARTURO;NAAR, SYLVIE  (contact)

PROGRAM_OFFICER_NAME: POLLARD-BRANCHARD, SUZANNE LEE

PROJECT_TERMS: Address;Adult;Age;AIDS prevention;behavior change;Black race;Caring;Cities;Clinic;collaborative approach;Competence;Contracts;Counseling;County;cultural competence;design;Development;Early Diagnosis;effectiveness outcome;Epidemic;evidence base;Evidence based practice;experience;Exploration, Preparation, Implementation, and Sustainment;Feedback;Florida;Goals;Health;HIV;HIV diagnosis;HIV Infections;Human immunodeficiency virus test;hybrid type 2 trial;implementation context;implementation fidelity;implementation framework;implementation outcomes;implementation science;implementation strategy;improved;innovation;Intervention;Latino;men;men of color;Methods;Monitor;motivational enhancement therapy;Outcome;outreach;peer;Persons;pre-exposure prophylaxis;Prevention;Prevention strategy;primary outcome;Provider;Public Health;Randomized;Recommendation;referral services;Risk Reduction;Sampling;scale up;self testing;Services;sexual minority men;Site;skills;social stigma;Strategic Planning;Testing;testing services;Training;United States;uptake;Viral;Washington;young adult;young men who have sex with men;Youth

PROJECT_TITLE: Scaling Up Implementation Strategies to Improve the DIAGNOSE and PREVENT Pillars for Young MSM in Florida


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_DEPT: PHYSIOLOGY

PHR: PROJECT NARRATIVE The overarching goal of the Systems and Integrative Biology Predoctoral Training Program in Cellular Systems and Integrative Physiology (CSIP Training Program) is to develop an inclusive and supportive graduate training environment to create a diverse pool of responsible and self-directed scientists who will enter the ever-changing biomedical career landscape with a broad understanding of cell biology and physiology across multiple biological scales. Through this systems approach, trainees will develop skill in critical thinking, quantitative literacy, and professional communication to become productive, ethical leaders in the biomedical workforce.

PI_NAMEs: CARON, KATHLEEN M (contact);SNIDER, NATASHA T

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Physiology;System;Training Programs

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Bioengineering;Nanotechnology

PHR: Project Narrative RhoGEF proteins represent a diverse array of signaling molecules that play critical roles both in normal human physiology and in diseases, especially cancer. The goal of this proposal is to gain a molecular understanding of how these proteins signal and are regulated. This knowledge will greatly facilitate the development of therapeutics for the treatment of diseases where RhoGEF proteins are implicated.

PI_NAMEs: CASH, JENNIFER NICOLE (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Architecture;Binding;Breast Melanoma;Cancer cell line;Cell division;Cell membrane;cell motility;Clinical;Complex;Cryoelectron Microscopy;Cyclic AMP-Dependent Protein Kinases;cytokine;Data;Disease;Enzymes;Family;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;G-substrate;Genes;Genetic Transcription;Goals;Growth;Growth Factor;GTP-Binding Proteins;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate Phosphohydrolases;Human;in vitro testing;inhibitor therapy;inorganic phosphate;insight;Knowledge;Laboratories;Length;Lipids;Malignant Breast Neoplasm;Malignant Neoplasms;member;Membrane;membrane assembly;Membrane Lipids;Metastatic Melanoma;Molecular;Monomeric GTP-Binding Proteins;Mutate;Mutation;nanodisk;phosphatidylinositol 3,4,5-triphosphate;Physiology;Play;Process;protein B;Protein Isoforms;Proteins;PTEN gene;rational design;Regulation;rho;Role;scaffold;Signal Pathway;Signal Transduction;Signaling Molecule;Signaling Protein;Surface;Tertiary Protein Structure;Therapeutic;therapeutic development;therapeutic target

PROJECT_TITLE: Structural and Functional Characterization of RhoGEF Regulation Using Nanodiscs to Assemble Membrane-associated Signaling Scaffolds

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Prevention

ORG_CITY: IRVINE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE  Immunosuppressive conditions, such as HIV infection, may play a major role in SARS-CoV-2 transmission and emergence of variants of concern. We will use advanced molecular methods to determine the effect of HIV infection on SARS-CoV-2 evolution and epidemiology in a high HIV-prevalent country. Information from our study could be used to develop interventions to prevent and prepare for emergence of SARS-CoV-2 variants of concern.

PI_NAMEs: MODONGO, CHAWANGWA ;NIEMANN, STEFAN ;SHIN, SANGHYUK SAM (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: 2019-nCoV;Affect;Area;Botswana;case finding;Case Study;CD4 Positive T Lymphocytes;Cell Count;Cells;Chronic;chronic infection;Clinical;Clinical Data;co-infection;cohort;Cohort Studies;Communities;comorbidity;Country;COVID-19;COVID-19 impact;COVID-19 incidence;COVID-19 pandemic;COVID-19 patient;COVID-19 prevention;COVID-19 severity;COVID-19 treatment;COVID-19 vaccine;Data;Development;Disease;DNA Sequence Alteration;Environment;Epidemic;epidemiologic data;Epidemiology;epidemiology study;Event;Evolution;experience;Foundations;Functional disorder;Future;future pandemic;Genetic Recombination;genome sequencing;genomic data;genomic epidemiology;global health;Goals;Health;High Prevalence;high risk;HIV;HIV Infections;Household;Immune;Immune system;Immunity;Immunocompetent;Immunocompromised Host;immunodeficiency;Immunosuppression;improved;Individual;Infection;insight;interest;Intervention;Knowledge;Methods;Molecular;Monitor;Mutation;National Institute of Allergy and Infectious Disease;pandemic disease;pandemic disruption;pandemic response;Patients;Pattern;Persons;Play;Population;population based;pressure;Prevalence;prevent;programs;Public Health;public health intervention;recruit;Research;Resistance;Risk Factors;RNA;Role;Sampling;Sampling Biases;SARS-CoV-2 B.1.1.529;SARS-CoV-2 B.1.617.2;SARS-CoV-2 genome;SARS-CoV-2 infection;SARS-CoV-2 transmission;SARS-CoV-2 variant;Subgroup;System;Time;transmission process;Tuberculosis;Vaccination;Variant;variants of concern;Viral;Viral Load result;Virus;whole genome

PROJECT_TITLE: The effect of HIV on SARS-CoV-2 transmission and emergence of variants of concern

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ORG_CITY: CAMBRIDGE

ORG_NAME: WHITEHEAD INSTITUTE FOR BIOMEDICAL RES

ORG_STATE: MA

PHR: PROJECT NARRATIVE  The Center for Genomic Editing and Recording will create technologies to enable robust, comprehensive exploration of genes and genetic pathways responsible for human disease in addition to the development of higher-level multichannel molecular recorders that will allow us to track and reconstruct the life history of cells in an in vivo setting. Collectively, these technologies have profound implications for genome science, therapeutic strategies for somatic disorders, and genetic diseases as well as understanding normal development and disease processes such as tumor evolution and the mechanism of metastases and response to therapeutic challenges. In addition, we aim to create a vibrant environment in which scholars across educational and socioeconomic levels can engage without barriers, where diverse students at every stage of development will be exposed to novel opportunities for training, research and skill development, and new ideas in a dynamic interdisciplinary research environment.

PI_NAMEs: ADAMSON, BRITTANY S.;ARYEE, MARTIN JOSEPH ANKRAH;LIU, DAVID R;STERNBERG, SAMUEL HENRY;WEISSMAN, JONATHAN S. (contact)

PROGRAM_OFFICER_NAME: FLETCHER, COLIN F

PROJECT_TERMS: 3-Dimensional;Acceleration;Architecture;base editor;Base Pairing;BCAR1 gene;Biochemistry;Bioinformatics;Biological;Biology;Cells;cellular engineering;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Complex;CRISPR/Cas technology;Detection;Development;Disease;DNA;DNA Binding;DNA Repair Pathway;DNA Sequence;DNA sequencing;Education;Education and Outreach;Endonuclease I;Engineering;Enhancers;Environment;Epigenetic Process;epigenome;epigenome editing;Evolution;experience;Exposure to;functional genomics;Gene Expression;General Hospitals;Generations;Genes;Genetic;Genetic Diseases;Genetic Transcription;genetic variant;Genetic Variation;Genome;genome editing;genome editor;Genome engineering;genome sciences;Genomic approach;Genomics;Goals;Heritability;Human;human disease;Human Genetics;Human Genome;improved;in vivo;Individual;Interdisciplinary Study;life history;Massachusetts;medical schools;Medicine;Messenger RNA;Methods;Mitochondria;Mitochondrial DNA;mitochondrial genome;Mitotic;Molecular;molecular clock;multidisciplinary;Mutation;Neoplasm Metastasis;next generation;novel;novel strategies;novel therapeutics;Nuclear;nuclease;Output;Pathway interactions;personalized medicine;Phylogenetic Analysis;Population;postmitotic;Preventive Medicine;prime editing;prime editor;Process;Protein Engineering;Proteins;Recording of previous events;Regulatory Element;Repression;Research;research and development;research facility;Research Personnel;Resolution;Resources;response;Safety;skill acquisition;socioeconomics;spatial integration;Structure;Students;System;Talents;Technology;Therapeutic;Therapeutic Intervention;Time;Tissues;tool;Toxic effect;Training;training opportunity;tumor;Universities;Untranslated RNA;Variant;Virus Diseases;Zinc Fingers

PROJECT_TITLE: Center for Genomic Editing and Recording: Development and Application of Next-Generation Genome and Epigenome Editing Methods to Advance the Study and Treatment of Human Disease

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative: The overarching goal of this R01 renewal is to advance our understanding of the impact that LKB1 inactivation has on mitochondrial bioenergetics, metabolism and therapy response in lung cancer. We propose to perform an in vivo structural and functional imaging study of mitochondrial heterogeneity in lung tumors following LKB1 inactivation using a novel approach that combines positron emission tomography (PET) imaging with ultra- resolution 3-dimensional electron microscopy and respirometry. These studies hold promise to deepen our mechanistic understanding of how LKB1 loss represses OXPHOS dependent metabolism through structural reorganization of mitochondria with the goal of improving therapeutic responses in LKB1MUT LUAD patients.

PI_NAMEs: SHACKELFORD, DAVID B (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: 3-Dimensional;Address;Adenosine Monophosphate;American;Apoptosis;Architecture;Area;Bioenergetics;Biological Markers;Biology;Cancer Patient;Cell Respiration;Cell Survival;Cells;chemosensitizing agent;conventional therapy;Crista ampullaris;Data;Defect;Development;Diagnosis;Diagnostic;diagnostic strategy;Disease;Disease Resistance;Electron Microscopy;Face;fatty acid oxidation;Functional Imaging;Goals;Health;Heterogeneity;Homeostasis;Human;Image;imaging study;Immuno-Chemotherapy;Immunocompetent;Immunotherapy;improved;in vivo;in vivo evaluation;inhibitor;Knowledge;KRAS2 gene;Lipids;Lung Adenocarcinoma;Lung Neoplasms;lung tumorigenesis;Malignant neoplasm of lung;Maps;Measures;Metabolic;Metabolism;Mitochondria;mitochondrial metabolism;Morphology;mouse model;mTOR Signaling Pathway;mutant;mutant mouse model;Mutation;Non-Small-Cell Lung Carcinoma;novel;novel diagnostics;novel strategies;novel therapeutics;Pathway interactions;patient derived xenograft model;Patients;Phosphoric Monoester Hydrolases;Phosphotransferases;Physiological;Positron-Emission Tomography;Refractory;Repression;Resolution;Respiration;restoration;Scanning;Spirometry;STK11 gene;structural imaging;Structure;Survival Rate;Technology;Testing;Therapeutic;therapy development;therapy resistant;Three-dimensional analysis;Tracer;treatment and outcome;treatment response;treatment strategy;tumor;Tumor Suppressor Genes;Work

PROJECT_TITLE: Imaging mitochondrial heterogeneity in LKB1 mutant lung cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Y(02)M]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: RICHLAND

ORG_NAME: BATTELLE PACIFIC NORTHWEST LABORATORIES

ORG_STATE: WA

PHR: Narrative: G-protein coupled membrane receptors are the most common targets for FDA-approved drugs, and their patterns of protein phosphorylation contain the information required for their activation and function. However, it is challenging to characterize these complex hyper-phosphorylated regions with accurate site- specific identification and quantification. We propose to develop and apply an ultrahigh resolution mass spectrometer using ion mobility spectrometry which will enable the necessary resolution and sensitivity to elucidate these complex hyperphosphorylated regions of proteins.

PI_NAMEs: JACOBS, JON  (contact);RAJAGOPAL, SUDARSHAN K

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Adaptor Signaling Protein;Address;Agonist;Amino Acid Motifs;Amino Acids;antagonist;Antibodies;beta-arrestin;Biological;Biological Assay;Biology;Cell Physiology;cell preparation;chemokine;Clinical;Collection;Complex;computerized data processing;Coupled;CXC chemokine receptor 3;CXCR3 gene;Data;Data Analyses;design;Detection;Development;dimension reduction;Disease;Dose;drug development;drug discovery;Drug Screening;Drug Targeting;experience;Family;FDA approved;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;GTP-Binding Proteins;Heterotrimeric GTP-Binding Proteins;high throughput screening;improved;Inflammatory;informatics tool;ion mobility;Ions;Isomerism;Ligands;mass spectrometer;Mass Spectrum Analysis;Membrane;Modernization;novel;novel strategies;overexpression;Pathway interactions;Pattern;Peptide Library;Peptides;Pharmaceutical Preparations;Pharmacology;Phosphopeptides;phosphoproteomics;Phosphorylated Peptide;Phosphorylation;Phosphorylation Site;Phosphotransferases;Play;Process;programs;Protein Region;Proteins;Proteomics;Reagent;receptor;recruit;Reproducibility;Research;Resolution;response;Role;Sampling;screening;Signal Transduction;Site;small molecule;small molecule libraries;Specificity;Spectrometry;Speed;Structure;System;T cell regulation;T-Cell Activation;T-Lymphocyte;Technology;Testing;Time;Transducers;Travel;ultra high resolution;United States National Institutes of Health

PROJECT_TITLE: A Novel high resolution MS platform for high-throughput screening of G protein-coupled receptors

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Physical Activity;Prevention

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE The rapid expansion of the US older adult population highlights the public health importance of preventing frailty—an age-related syndromic state of vulnerability and heightened risk of adverse health outcomes. Increasing physical activity is a promising intervention to prevent frailty but initiating and maintaining habitual physical activity is difficult for older adults, particularly those encumbered by health challenges. This project aims to test and compare novel, remotely deployable strategies to reduce daily sedentary time among inactive, prefrail older adults as a first step to form long-lasting physical activity habits and combat frailty.

PI_NAMEs: WANIGATUNGA, AMAL ASIRI (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: Accelerometer;Address;Adult;Age;age related;Aging;aging related;American;Anxiety;Award;Behavior;Biological;Biological Markers;Biology;Biometry;career development;Clinical Research;Clinical Trials;combat;Communities;Competence;Conduct Clinical Trials;Data;design;Development Plans;Dose;Effectiveness;effectiveness evaluation;Epidemiology;Exercise;Faculty;Fatigue;frailty;Geriatrics;Goals;Guidelines;Habits;Health;Health behavior;human old age (65+);improved;Incidence;Inflammation;inflammatory marker;Infrastructure;Interleukin-6;Intervention;Link;Measurement;Measures;meetings;member;Mentored Research Scientist Development Award;Mentors;Moods;novel;older adult;Outcome;Pain;Pathway interactions;Patient Outcomes Assessments;Physical activity;Pilot Projects;Population;pre-clinical;prevent;primary outcome;programs;Psychology;psychosocial;Public Health;Randomized;Recommendation;Records;Research;Research Personnel;response;Risk;secondary outcome;sedentary;sedentary lifestyle;Self Efficacy;Serum;Stress;Structure;System;Teacher Professional Development;Testing;therapy design;Time;TNFRSF1A gene;Translational Research;Universities;Walking

PROJECT_TITLE: The START trial: a proof-of-concept sedentary reduction program for prefrail older adults

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ORG_DEPT: BIOCHEMISTRY

PHR: Project Narrative: This proposal will fill gaps in understanding crucial aspects of redox regulation and catalysis by metalloproteins from microbes to humans. Our work will integrate a wide variety of biological, biophysical, biochemical and computational approaches to reveal novel mechanisms with broad significance to human health, the environment, and biotechnology.

PI_NAMEs: RAGSDALE, STEPHEN WILEY (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TITLE: Metalloprotein Mechanisms of Redox Regulation and Catalysis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biodefense and Related Countermeasures;Cancer;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dissemination and Implementation Research;Drug Abuse (NIDA only);Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric - AIDS;Prevention;Rare Diseases;Substance Misuse;Telehealth;Tuberculosis

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative: Through our efforts, we will enhance our understanding of the HIV care cascades and the outcomes of care in East Africa, provide insights on the optimal structure and impact of care and treatment programs, expand the set of tools available to inform implementation and operations research in resource-constrained settings and inform policy among stakeholders and decision makers at every level in the region as well as the broader HIV/AIDS scientific community.

PI_NAMEs: SEMEERE, AGGREY SEMWENDERO;WOOLS-KALOUSTIAN, KARA KAY (contact);YIANNOUTSOS, CONSTANTIN THEODORE

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: 2019-nCoV;Achievement;Acquired Immunodeficiency Syndrome;Address;Adolescent and Young Adult;Affect;Africa;age group;AIDS related cancer;antiretroviral therapy;Behavioral;cancer diagnosis;cardiovascular risk factor;care outcomes;Caring;Cervical;Clinic;Clinical;co-infection;cohort;Collaborations;Communities;comorbidity;contextual factors;Country;COVID-19;COVID-19 pandemic;Data;Data Sources;Databases;Dermatology;Development;Diagnosis;Disease;eHealth;Environment;Epidemiology;Evolution;experience;Funding;Gender;Genetic;Geography;Goals;Government;Grant;Health;Healthcare;HIV;HIV/AIDS;Home;Image;implementation evaluation;implementation research;Infant;insight;International;Joints;Kaposi Sarcoma;Kenya;Knowledge;Learning;Liver diseases;Longevity;Lung;Machine Learning;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Measures;Mental Depression;Mental Health;Methodology;Methods;Movement;new technology;Newborn Infant;novel;Operations Research;Outcome;Patient-Focused Outcomes;Patients;Persons;Policies;post-COVID-19;Pregnancy;programs;Public Health;Research;Resource-limited setting;Risk Factors;Sampling;scale up;Sentinel;Statistical Methods;Structure;substance use;syndemic;Tanzania;Technology;telehealth;Telemedicine;tool;treatment guidelines;Treatment outcome;treatment program;treatment strategy;Tuberculosis;Tuberculosis diagnosis;Uganda;United Nations;Viral

PROJECT_TITLE: East Africa International Epidemiology Database to evaluate AIDS (IeDEA) Regional Consortium


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Childhood Injury;Mental Health;Nanotechnology;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PHR: To develop diamagnetic chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) theranostic biosensors and complementary CEST MRI nanotheranostic agents for image-guided combination therapy to prevent and repair radiotherapy-induced brain injury in pediatric brain tumor survivors.

PI_NAMEs: NGEN, ETHEL JOSO (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Advanced Development;behavior test;Biodistribution;bioluminescence imaging;biomaterial compatibility;Biosensor;Brain Injuries;cancer survival;Central Nervous System Neoplasms;Chemicals;Childhood;Childhood Brain Neoplasm;Childhood Central Nervous System Neoplasm;Chronic;clinical translation;clinically significant;Combined Modality Therapy;Convection;Drug Delivery Systems;drug release kinetics;Esters;experience;fluorescence imaging;Histology;Image;image guided;imaging agent;imaging capabilities;Immunohistochemistry;improved;in vivo;Injury;Learning;Life;Magnetic Resonance;Magnetic Resonance Imaging;Memory;Methods;Microglia;migration;Modeling;Molecular;nanocarrier;Nanotechnology;nanotheranostics;nerve stem cell;Neurocognitive Deficit;neuroinflammation;Neurologic Deficit;neuroprotection;Neuroprotective Agents;non-invasive imaging;non-invasive monitor;Outcome;Oxidative Stress;pediatric patients;Pharmaceutical Preparations;Positron-Emission Tomography;pre-clinical;prevent;Procedures;prophylactic;Proteins;Quality of life;Radiation therapy;radiotracer;regenerative;repaired;Reporter Genes;response;screening;Signal Transduction;Site;stem cell delivery;stem cell survival;Stem cell transplant;stem cells;Survivors;Techniques;theranostics;Therapeutic;Tissues;tool;Transplantation;treatment response;Treatment Side Effects;Validation

PROJECT_TITLE: Image-guided combination therapies for radiotherapy-induced neurocognitive impairment in pediatric brain tumor survivors

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The current proposal “Studying the role of eIF4A in pancreatic tumorigenesis” will use organoid models, RNA genomics, and biochemical tools to realize the potential of eIF4A as a therapeutic target against pancreatic cancer. We anticipate our results will establish mechanistic understanding and therapeutic inroads for translation reprogramming in pancreatic cancer.

PI_NAMEs: CHIO, CHRISTINE IOK IN (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: 5' Untranslated Regions;Affect;biochemical tools;Biological;Biological Assay;Biology;Cell Death;Cell Survival;Cells;Clinical;clinically relevant;Combined Modality Therapy;CRISPR/Cas technology;Data;Dependence;Development;dimethyl sulfate;Doxycycline;Duct (organ) structure;Ductal Epithelial Cell;Enzymes;Ethers;Etiology;Eukaryotic Initiation Factors;gemcitabine;Genetically Engineered Mouse;genomic RNA;genomic tools;glucose metabolism;Glucose Transporter;glucose uptake;Goals;Impairment;improved;in vivo;inhibitor;insight;Iron;Knock-out;KRAS2 gene;Link;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Messenger RNA;Metabolic;Metabolic Pathway;Modeling;Mouse Strains;mRNA Translation;Mus;Mutation;novel;novel therapeutics;Oncogenic;Organoids;pancreatic cancer cells;Pancreatic duct;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic tumorigenesis;patient response;Patients;Phospholipids;Polyribosomes;Polyunsaturated Fatty Acids;predictive marker;programs;Protein Biosynthesis;Proteins;Quantitative Reverse Transcriptase PCR;Regulation;Reporter;Resistance;resistance mechanism;RNA Caps;RNA Folding;RNA Helicase;Role;Signal Pathway;small hairpin RNA;Specimen;synergism;Testing;Therapeutic;therapeutic target;Transcript;Transcription Initiation;Transcription Initiation Site;Translations;translatome;transplant model;tumor growth;Up-Regulation;Work

PROJECT_TITLE: Studying the role of eIF4A in Pancreatic Cancer

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

ORG_CITY: OMAHA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: CREIGHTON UNIVERSITY

ORG_STATE: NE

PHR: Prions are infectious protein-only zoonotic agents that can rapidly evolve in a new replication environment. Little is known about how prions can overcome new replication environments that can include anti-prion drugs, environmental degradation, and transmission to a new host species. The long term goal of this application is to determine the relative contributions of the dominant prion strain and substrains to prion replication in new environments.

PI_NAMEs: BARTZ, JASON C (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TITLE: Contributions of prion strains and substrains to prion zoonotic potential and evolution

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Cancer;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Hematology;Immunotherapy;Microbiome;Nutrition;Prevention;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Narrative Hematopoietic cell transplantation (HCT) offers a great promise for the treatment of a variety of diseases including blood cancers, but causes a major complication termed graft-versus-host disease (GVHD). Trillions of bacteria habit in human's gastrointestinal tract, some of which are potential harmful while many are beneficial to the host health. The current research aims at identifying and validating individual bacterial strains that can help to reduce GVHD and improve patient health, which may ultimately bring a benefit to the patients who need HCT for a therapy.

PI_NAMEs: YU, XUE-ZHONG  (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Acute Graft Versus Host Disease;adaptive immunity;Affect;Allogeneic Bone Marrow Transplantation;Allogenic;Antibiotics;Bacteria;bacterial community;Bacteroides fragilis;Benign;Biological Response Modifiers;Bone Marrow Transplantation;chronic graft versus host disease;Clinic;Clinical;Clinical Research;Clinical Trials;commensal bacteria;Communities;Complication;Consensus;Decontamination;Development;Diet;Diet Modification;Disease;Donor person;Epithelium;experimental study;fecal transplantation;Feces;Fostering;Gastrointestinal tract structure;Goals;graft vs host disease;graft vs leukemia effect;gut homeostasis;gut microbiota;Habits;Health;Hematopoietic;Hematopoietic Neoplasms;Hematopoietic Stem Cell Transplantation;Homeostasis;Human;Immune;Immune response;immunoregulation;Immunosuppression;improved;Individual;Injury;Intervention;intestinal barrier;Intestinal permeability;Intestines;Invaded;Lactobacillus;leukemia;Malignant - descriptor;Mediating;member;Microbe;microbial;microbiota;microorganism;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mucous Membrane;Mus;Outcome;pathogen;Pathogenesis;Patients;pre-clinical;prebiotics;preclinical study;preservation;prevent;Probiotics;Research;response;Role;screening;Severities;Severity of illness;T cell response;T-Lymphocyte;Testing;Therapeutic;Translations;transplant model;Transplant Recipients;Transplantation;Vancomycin resistant enterococcus;Xenograft Model

PROJECT_TITLE: Control of GVHD by Probiotics with individual Commensal Bacteria

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative The proposed research is relevant to public health because the CD53 interaction network regulates normal B cell trafficking and controls immune response and antibody production in humans. This network also facilitates malignant B cell trafficking to bone marrow and lymphoid organs. Thus, understanding the specific functional role of CD53 network and the underlying mechanisms will lead to the better management of normal immune response and to new therapeutic strategies for treating leukemia and lymphoma.  .

PI_NAMEs: LI, WEIKAI ;SCHUETTPELZ, LAURA G. (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Adhesions;Affect;Annexins;Antibody Formation;Antigens;B-Cell Development;B-Cell Leukemia;B-Lymphocytes;Binding;Biochemical;Biological Assay;Bone Marrow;Cell Adhesion;Cell Communication;cell motility;Cell Physiology;Cell surface;Cells;chemokine;Chemotactic Factors;Coculture Techniques;cohort;Collaborations;Complex;cytokine;Cytoskeleton;Data;Electrons;Endothelium;experimental study;Family;Family member;Goals;Growth;Hematopoiesis;Homing;Human;Immune response;immune system function;Immunoglobulins;Immunohistochemistry;Impairment;In Vitro;in vivo;Infection;insight;Integral Membrane Protein;knock-down;Label;leukemia/lymphoma;Link;lymphoid organ;Malignant - descriptor;Malignant Neoplasms;Marrow;Mass Spectrum Analysis;Mediating;member;Methods;Microscopic;migration;Modeling;Molecular;Molecular Conformation;monolayer;Motility;Mus;novel;novel therapeutic intervention;Population;Predisposition;Process;Proliferating;Proteins;Public Health;Reporting;Research;Research Personnel;response;Role;secondary lymphoid organ;Serum;Signal Transduction;Signaling Protein;Spleen;stathmin;Structure;Techniques;Testing;therapeutic target;tool;trafficking

PROJECT_TITLE: Defining the partner interaction network of the tetraspanin CD53 in regulating B cell trafficking

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Pediatric

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: The Childhood Infections Research Program (CHIRP) for 10 years has trained and facilitated the career development of investigators studying infectious diseases relevant to children. The outcomes will be investigators who will make a long-term impact on the fundamental biology, diagnosis, prevention, and treatment of infections in children. The public health relevance is high for the direct impact on the health of children. 2

PI_NAMEs: CASSAT, JAMES E (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Childhood;Infection;programs;Research

PROJECT_TITLE: Childhood Infections Research Program

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Genetics;Immunotherapy

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Natural killer (NK) cells are cytotoxic effector cells that are important for antitumor and antiviral immunity. Improved understanding of the ontological relationships and transcription factor circuitry regulating NK cell differentiation and function is critical as NK cells advance into the immunotherapeutic arena. Our preliminary data suggests that Bcl11b, a transcription factor studied primarily in T cell development, may be a master transcription factor regulating canonical and adaptive NK cell differentiation. The experiments outlined in this application are designed to test this hypothesis.

PI_NAMEs: CICHOCKI, FRANK  (contact)

PROJECT_TERMS: adaptive immune response;Adoptive Cell Transfers;Adoptive Transfer;Advanced Malignant Neoplasm;antiviral immunity;ATAC-seq;Automobile Driving;Binding;cancer cell;CD8-Positive T-Lymphocytes;Cell Differentiation process;Cell Line;Cell Maturation;Cell Physiology;Cell Separation;Cell-Mediated Cytolysis;Cells;Characteristics;chemokine;ChIP-seq;Complement;cytokine;Cytokine Receptors;Cytokine Signaling;Cytomegalovirus;cytotoxic;Data;design;Development;Drops;Effector Cell;Enhancers;Epigenetic Process;Exhibits;Experimental Designs;experimental study;Flow Cytometry;Foundations;Funding;Gene Expression Profile;Genes;Genetic Complementation Test;Genetic Transcription;Genomic Segment;Hematopoietic stem cells;Human;Immune;Immune response;Immunologic Memory;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;in vivo Model;Individual;induced pluripotent stem cell;Inflammatory;interest;knock-down;Knowledge;Literature;Lymphocyte;Mediating;Modeling;Mus;Natural Killer Cell Immunotherapy;Natural Killer Cells;Ontology;overexpression;Patients;peripheral blood;Phenotype;pre-clinical;Process;programs;promoter;Property;receptor;Receptor Signaling;Role;seropositive;Signaling Protein;Sorting;T-Cell Development;T-Lymphocyte;T-Lymphocyte Subsets;Testing;transcription factor;transcriptome sequencing;tumor;Tumor Immunity;Umbilical Cord Blood;Viral;Work

PROJECT_TITLE: Bcl11b: A Master Transcription Factor Controlling Human NK Cell Development

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE We recently published an easy-to-use battery that can predict upcoming reuse events in patients being treated for opioid use disorder (OUD), and we then migrated that battery to a smartphone platform and demonstrated retention and compliance of over 85% in an OUD population. Our analysis of existing clinical trial data suggests that adjusting buprenorphine dosing in response to reuse events reduces relapse rates. Here we propose to: (1) test the hypothesis that our battery can be used to trigger dose adjustments before reuse events and that this has the effect of reducing reuse and relapse in medication-based OUD treatment; (2) examine the willingness of clinicians to employ this strategy; and (3) examine the cost-effectiveness of these adjustments.

PI_NAMEs: GLIMCHER, PAUL W (contact);MURPHY, SEAN M.;TOFIGHI, BABAK

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Algorithms;American;arm;Basic Science;behavior prediction;Buprenorphine;buprenorphine treatment;Cellular Phone;Clinical;Clinical Trials;Clinical Trials Network;cohort;Conduct Clinical Trials;Contracts;cost;Cost Analysis;cost effective;cost effectiveness;Cost Measures;cost-effectiveness evaluation;Criminal Justice;Data;Data Analyses;Dose;Dropout;drug testing;economic evaluation;Effectiveness;Event;Eye;Feasibility Studies;Future;Goals;Health;Health Care Costs;Health Care Sector;Health Personnel;Homelessness;Hospitals;illicit opioid;improved;inner city;instrument;Intervention;Measurement;Measures;Methadone;methadone treatment;Methodology;migration;National Institute of Drug Abuse;Nurses;Opiate Addiction;Opioid;opioid misuse;opioid use;opioid use disorder;Outcome;Output;Patients;Pharmaceutical Preparations;Physicians;Pilot Projects;Policies;Policy Maker;Population;prediction algorithm;Probability;Productivity;Professional counselor;Provider;Psychiatry;Publishing;Quality-Adjusted Life Years;Randomized;Recovery;Relapse;Resources;response;safety net;Salivary;Site;Societies;stakeholder perspectives;Surveys;System;Testing;Time;tool;treatment as usual;Treatment Effectiveness;usability;user-friendly;willingness

PROJECT_TITLE: SOAR: Smartphones for Opioid Addiction Recovery

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE – OVERALL UNC CFAR The UNC Center for AIDS Research provides essential infrastructure support for the wide range of HIV related research for its members. This research contributes to the major goals of Ending the HIV Epidemic and HIV prevention and cure, and has overarching public health impact.

PI_NAMEs: SWANSTROM, RONALD I (contact)

PROGRAM_OFFICER_NAME: WONG, ELAINE WAI-KEN

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adolescent;AIDS clinical trial group;AIDS prevention;Analytical Chemistry;antiretroviral therapy;Appointment;Area;Award;base;Behavioral;behavioral and social science;Behavioral Sciences;Biological Specimen Banks;Biometry;Brain;China;CLIA certified;Clinical;Clinical Pharmacology;co-infection;cohort;Collaborations;collaboratory;Communicable Diseases;Communication;Communities;community collaboration;comorbidity;Comprehensive Cancer Center;Country;Criminal Justice;Data;Data Analyses;data management;Databases;Development;Disparity;Distance Learning;Education;Electronics;Ensure;Epidemic;Epidemiology;Event;Faculty;Family health status;Federal Government;fighting;Funding;Future;global health;Goals;Growth;Health;high risk population;Historically Black Colleges and Universities;HIV;HIV risk;HIV Vaccine Trials Network;HIV/STD;Immunology;Infrastructure;innovation;Institution;Interdisciplinary Study;Interest Group;International;International Maternal Pediatric Adolescent AIDS Clinical Trials;Internships;Investments;Knowledge;Laboratories;Leadership;Link;Malawi;Malignant Neoplasms;member;Mentors;Microbiology;Newsletter;North Carolina;novel;novel therapeutics;Online Systems;outreach;Patients;Persons;Pharmacology;Population;Positioning Attribute;prevent epidemics;Prevention;programs;Public Health;Publishing;Reporting;Research;Research Activity;Research Personnel;Research Priority;Research Support;Resources;Risk;Schools;Services;Site;social media;social science research;Social Sciences;South Africa;South Carolina;Specimen;Strategic Planning;symposium;Talents;Technology;tool;Training;transgender women;Translational Research;transmission process;underrepresented minority student;Underserved Population;United States Dept. of Health and Human Services;United States National Institutes of Health;Universities;Vietnam;virology;Work;working group;young men who have sex with men;Zambia

PROJECT_TITLE: The University of North Carolina Center for AIDS Research


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Area;Award;base;Budgets;China;Collaborations;Communicable Diseases;Communication;Communities;community collaboration;community engagement;Consultations;Country;Development;diversity and inclusion;Education;Effectiveness;Electronics;Ensure;Epidemic;Equipment;Evaluation;Faculty;Faith-based organization;Fostering;Funding;Generations;Goals;Healthcare;Historically Black Colleges and Universities;HIV;HIV/AIDS;HIV/STD;innovation;interest;Interest Group;International;Laboratories;Leadership;Logistics;Malawi;Mediation;medical schools;meetings;member;Modernization;Myron;Newsletter;next generation;North Carolina;novel;organizational structure;outreach;outreach program;Peer Review;Performance;Periodicals;Policies;Procedures;Process;public-private partnership;Publications;recruit;Reporting;Research;Research Activity;research and development;Research Personnel;Resource Allocation;Resources;Role;Services;social media;South Africa;South Carolina;Standardization;Strategic Planning;Structure;Students;success;Surveys;symposium;tenure track;Therapeutic;Training;United States National Institutes of Health;Universities;Vietnam;web site;webinar;Work;working group;Zambia

PROJECT_TITLE: UNC Center for AIDS Research Core A Administration


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Eye Disease and Disorders of Vision;Transplantation

ORG_CITY: Tampa

ORG_NAME: JAEB CENTER FOR HEALTH RESEARCH, INC.

PHR: Project Narrative Diabetes Endothelial Keratoplasty Study (DEKS): Impact of Diabetes on Corneal Transplant Success and Endothelial Cell Loss As individuals with diabetes comprise an increasing proportion of the donor cornea pool as well as the recipients of the donor tissue, questions continue to arise regarding the suitability of tissue from donors with diabetes for corneal transplantation, a major health concern considering nearly 50,000 tissues were distributed by United States eye banks and used for corneal transplants by United States surgeons in 2018. The DEKS will conduct a large, prospective, multi-center, masked clinical trial assigning corneas from donors with or without well characterized diabetes status to patients undergoing corneal transplantation, also characterized by diabetes status. The study will examine transplant success and the loss of endothelial cells after surgery, definitively determine the impact of donor and recipient diabetes on these outcomes, and thus help guide the eye banking and surgical community as to the safety and effectiveness of transplanting donor corneas from individuals with diabetes.

PI_NAMEs: BAUZA, COLLEEN  (contact)

PROGRAM_OFFICER_NAME: LE, JIMMY TOAN

PROJECT_TERMS: Address;Adherence;Advanced Glycosylation End Products;Affect;aging population;Applications Grants;Autopsy;Categories;Cause of Death;Cell Density;Cells;Clinical;Clinical Management;Clinical Research;clinical research site;clinical trial enrollment;Clinical Trials;Communication;Communities;Companions;Confidence Intervals;Cornea;Data Analyses;data integrity;data management;Data Management Resources;data repository;Descemet's membrane;design;Diabetes Mellitus;diabetes risk;diabetic;Donor person;Drug or chemical Tissue Distribution;Effectiveness;Endothelial Cells;Endothelium;Equilibrium;Exclusion;Eye;Eye Banks;Eye Surgeon;Failure;follow-up;Funding;glycemic control;Glycosylated hemoglobin A;Goals;Grant;Growth;Health;human subject;Individual;Institutional Review Boards;Keratoplasty;Masks;Measures;Modeling;Monitor;non-diabetic;Operative Surgical Procedures;Ophthalmologic Surgical Procedures;Outcome;oxidation;Participant;participant safety;Patient Participation;Patients;Penetrating Keratoplasty;Population;Postoperative Period;preservation;Procedures;Process;prospective;Protocols documentation;Public Health;quality assurance;recruit;Research;Resources;Safety;Sample Size;secondary analysis;Severities;Severity of illness;Side;Site;Skin;sound;standard of care;Statistical Data Interpretation;Statistical Methods;success;Surgeon;System;Time Study;Tissue Donors;Tissue Transplantation;Tissues;Transplantation;United States;United States National Institutes of Health;Universities;Variant;web site

PROJECT_TITLE: Diabetes Endothelial Keratoplasty Study: Impact of Diabetes on Corneal Transplant Success and Cell Loss


PI_NAMEs: MACQUEEN, KATHLEEN M (contact)

PROJECT_TERMS: Achievement;Acquired Immunodeficiency Syndrome;Address;Administrative Supplement;Area;Award;base;cohort;Collaborations;Communication;Communication Tools;Communities;Consultations;Data Analyses;data resource;Databases;Development;Educational workshop;Effectiveness;Ensure;Evaluation;experience;Faculty;Fees;Fellowship;Fellowship Program;follow-up;Fostering;Funding;Funding Opportunities;Geography;global health;Goals;Grant;Health;Historically Black Colleges and Universities;HIV;HIV/AIDS;innovation;Institution;Interest Group;International;Investments;meetings;member;mentoring community;Mentors;Mentorship;minority investigator;Mission;Modeling;Monitor;multidisciplinary;next generation;North Carolina;online resource;Outcome;Outcomes Research;outreach;Paper;peer;Peer Review;Performance;Pilot Projects;Policies;Procedures;Process;programs;Publications;Research;research data dissemination;Research Personnel;Research Priority;Resources;response;Services;Site;Standardization;Strategic Planning;Structure;success;Surveys;symposium;synergism;Time;tool;Training;Training Support;Underrepresented Minority;United States National Institutes of Health;Universities;webinar;Work;working group

PROJECT_TITLE: UNC Center for AIDS Research Core B Developmental


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: ERON, JOSEPH J (contact)

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;adjudication;AIDS clinical trial group;AIDS prevention;Basic Science;Biological;Biopsy;Blood;Censuses;Clinic;Clinical;clinical care;Clinical Data;Clinical Research;clinical trial implementation;Clinical Trials Network;cohort;Cohort Studies;Collaborations;Collection;Communities;comparative;Computerized Medical Record;cost effective;cost efficient;Creativeness;Data;Data Collection;data integration;data management;Data Reporting;data resource;Data Sources;Data Storage and Retrieval;database design;Environment;Epidemic;Epidemiology;Evaluation;experience;faculty mentor;Fostering;Funding;Grant;Growth;HIV;HIV Vaccine Trials Network;Human immunodeficiency virus test;improved;Infrastructure;innovation;Interest Group;International;Intervention;Intervention Trial;K-Series Research Career Programs;Laboratories;Leadership;Manuscripts;meetings;Mentors;Mentorship;Methods;Mission;Morbidity - disease rate;mortality;North Carolina;novel;Observational Study;Organ;Outcome;outreach;Paper;Participant;Pathogenesis;Patient Outcomes Assessments;patient population;Patient Recruitments;Patients;Performance;Persons;Policies;Positioning Attribute;Postdoctoral Fellow;Prevention;Procedures;Process;Productivity;programs;prospective;protocol development;Public Health;public health research;Ramp;Randomized;recruit;reproductive tract;Research;Research Infrastructure;Research Personnel;Research Priority;Research Support;Resources;response;Risk;sample collection;Sampling;Science;Services;Site;skills;Social Behavior;Specimen;Standardization;Strategic Planning;Structure;Students;Surveys;System;Technology;Thinking;Time;Tissues;Training;Translational Research;translational study;transmission process;United States National Institutes of Health;Universities;web-enabled;Work;working group

PROJECT_TITLE: UNC Center for AIDS Research Core C Clinical


PI_NAMEs: KASHUBA, ANGELA D (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adherence;AIDS clinical trial group;AIDS prevention;Ally;Analytical Chemistry;antiretroviral therapy;Applications Grants;Area;base;Biological;Biological Assay;Blood;Cell Separation;Certification;Chemistry;Clinical;Clinical Pharmacology;Clinical Research;Clinical Trials;Clinical Trials Network;cohort;Collaborations;Communities;comorbidity;Complex;Consultations;cost;Country;Data;data repository;design;Development;drug development;Drug Exposure;Drug Industry;Dryness;Environment;Epidemic;Epidemiology;Evaluation;Faculty;Feedback;Formulation;Foundations;Generations;global health;Goals;Government;Grant;Hair;Health;Historically Black Colleges and Universities;HIV;HIV Vaccine Trials Network;Image;Imaging technology;Implant;Individual;Infrastructure;Injectable;innovation;innovative technologies;Institution;Interest Group;International;International Maternal Pediatric Adolescent AIDS Clinical Trials;Leadership;Liquid substance;meetings;member;Methodology;Methods;Modeling;Monitor;Monte Carlo Method;Mucous Membrane;multidisciplinary;Needs Assessment;next generation;NIH Grants and Contracts;Nonprofit Organizations;North Carolina;novel;outreach;Performance;Persons;pharmacokinetics and pharmacodynamics;Pharmacology;pharmacometrics;Pharmacy Schools;Policies;Population;pre-clinical;Prevention;Private Sector;Procedures;Publications;Research;Research Design;Research Personnel;Research Priority;Resources;response;Services;simulation;small molecule;Spottings;Standardization;Strategic Planning;Surveys;Techniques;Therapeutic;Tissues;Toxic effect;transgender women;translational approach;Translations;United States National Institutes of Health;Universities;Work;working group;World Health Organization

PROJECT_TITLE: UNC Center for AIDS Research Core E Clinical Pharmacology/Analytical Chemistry


PI_NAMEs: HUDGENS, MICHAEL G (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;AIDS prevention;Applications Grants;Area;Biological Assay;Biometry;Biostatistics Core;Clinical;Clinical Trials Network;co-infection;Cohort Studies;Collaborations;Communities;comorbidity;Consultations;Data;data management;database design;design;Development;Development Plans;Epidemic;Epidemiology;Evaluation;experience;Faculty;Fostering;Funding;Goals;Grant;HIV;HIV therapy;HIV/AIDS;Infrastructure;innovation;Institution;Interest Group;International;Laboratories;Leadership;Manuscripts;meetings;member;Mentors;Mentorship;Methodology;Methods;Monitor;next generation;North Carolina;Observational Study;outreach;Peer Review;Performance;Policies;Postdoctoral Fellow;Preparation;Prevention;preventive intervention;Procedures;Productivity;programs;Publications;Research;Research Design;Research Methodology;Research Personnel;Research Support;Resources;Sample Size;Services;sound;Standardization;Statistical Data Interpretation;Statistical Methods;statistical service;statistics;Strategic Planning;Students;Surveys;Training;Training and Education;training opportunity;treatment optimization;United States National Institutes of Health;Universities;Vaccines;Work;working group;Writing

PROJECT_TITLE: UNC Center for AIDS Research Core F Biostatistics