NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Project Narrative Although advances have been made in the understanding of the pathogenesis of glioblastoma multiforme, this knowledge has not been translated into encouraging outcomes. We have introduced a new classification of glioblastoma that highlights the fundamental functional states of glioblastoma cells and delivers prognostic and therapeutic information. This grant proposes to study evolution of glioma cellular states, investigate the changes of cell states under therapy pressure, and test points of interventions for targeted therapeutics identified by integrating genomics and proteomics.

PI_NAMEs: IAVARONE, ANTONIO ;LASORELLA, ANNA  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: addiction;Address;Adult;Aftercare;Alkylating Agents;Automobile Driving;Bar Codes;Basic Science;Biological Markers;cancer cell;Cancer Patient;cancer proteomics;Cells;Classification;Clinic;Clinical;Clinical Research;cohort;Combined Modality Therapy;Communities;computerized tools;Data;Dependence;Diagnosis;Disease;DNA-dependent protein kinase;Elements;Endowment;Evolution;Excision;Exhibits;Experimental Models;experimental study;Favorable Clinical Outcome;Gene Mutation;Genetic;Genetic Variation;genomic data;Genomics;Genotype;Glioblastoma;Glioma;Grant;Heritability;Human;improved;In Vitro;in vitro Model;in vivo;Individual;inhibitor;innovation;Inter-tumoral heterogeneity;Intervention;Knowledge;Laboratories;Lesion;Link;Malignant Neoplasms;Metabolic;metabolomics;Mitochondria;Modeling;mouse model;Multiomic Data;neoplastic cell;Neurons;Nodal;novel;novel strategies;Operative Surgical Procedures;Organoids;Outcome;Oxidative Phosphorylation;Pathogenesis;Pathway interactions;patient subsets;Patients;pharmacologic;Pharmacotherapy;phosphoproteomics;Phosphorylation Inhibition;pre-clinical;Preclinical Testing;pressure;progenitor;Prognosis;prognostic;programs;Protein Kinase;Proteomics;Radiation;Radiation therapy;rational design;reconstruction;Recurrence;Reporting;Research;Resistance;Resources;Reverse engineering;Signal Transduction;single cell analysis;single-cell RNA sequencing;Stratification;Subgroup;success;targeted treatment;temozolomide;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;therapeutic target;tool;transcriptomics;Translating;tumor;Tumor Biology;tumor microenvironment;Tumor Stem Cells;Validation;Work

PROJECT_TITLE: Evolution and targeting of the functional states of glioblastoma

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Sleep Research

ORG_CITY: GAINESVILLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHYSIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE Across the globe, the number of people diagnosed with Parkinsonism doubled since 1990, and is estimated that ~14 million people will be diagnosed with Parkinsonism by 2040. For over 200 years now, Parkinsonism has been defined by clinical motor deficits, which has limited our ability to identify biomarkers for the detection of the disorder before clinical diagnosis. Here, we will study a preclinical model of Parkinsonism, known as rapid eye movement (REM) behavior disorder (RBD), to define a Mild Parkinson Impairment (MPI) before a clinical Parkinsonism diagnosis, using innovative markers that cut across imaging and physiology.

PI_NAMEs: JAFFEE, MICHAEL S.;VAILLANCOURT, DAVID E (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: alpha synuclein;Alzheimer's Disease;Area;Autopsy;Basal Ganglia;Behavior Control;Behavioral;Biological Assay;Biological Markers;biomarker identification;Brain;Brain Stem;Clinical;clinical diagnosis;Conduct Clinical Trials;Corpus striatum structure;Data;Dementia;Dementia with Lewy Bodies;Deposition;Detection;Development;Diagnosis;Diffusion;Disease;dopaminergic neuron;Early identification;Exhibits;experience;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Image;Impairment;Individual;innovation;Lewy Bodies;Longitudinal Studies;Lower Extremity;Measures;Methods;mild cognitive impairment;Motor;motor control;motor deficit;motor impairment;Movement;Multiple System Atrophy;Nerve Degeneration;neuroimaging;Neurologist;Neurology;novel therapeutics;Parkinson Disease;Parkinsonian Disorders;Pathologic;Pathology;Patients;Persons;Physiology;Pontine structure;pre-clinical;Pre-Clinical Model;prion-like;putamen;REM Sleep Behavior Disorder;Research Personnel;Series;Severities;Skin;Skin Tissue;Substantia nigra structure;synucleinopathy;Testing;Time;Upper Extremity;Water;water diffusion;Work

PROJECT_TITLE: Preclinical Markers of Parkinsonism

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Disability Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: PUBLIC HEALTH RELEVANCE There is a critical need for culture-appropriate and sustainable evidence-based community mental health interventions that can be readily and effectively implemented globally in low-resource settings with children generally at risk from disease, malnutrition and neglect. In this proposal, we build on our formative feasibility trial of the Mediational Intervention for Sensitizing Caregivers for CBOs (MISC-CBO) that has shown positive mental health outcomes for Orphans and Vulnerable Children (OVC). We will conduct a repeated measures cluster randomized trial to fully establish the effectiveness and transdiagnostic mechanisms of action, cost- effectiveness and implementation climate and readiness of MISC-CBO. Our program of research is therefore in line with the third strategic objective of the NIMH (“Strive for prevention and cure”) that articulates the need for validated targets for interventions, and improved methods to match interventions to underserved individuals and populations that can be scaled for greater public health impact. Once the efficacy of MISC-CBO has been fully established, it has the potential to be adapted and used to address other public health epidemics that impede supportive caregiving and positive child development. Empowered CBO careworkers can for instance work with parents to transfer their MISC skills, or MISC can be adapted and evaluated in families in which one or both parents are substance abusers, have serious mental illness or other disabilities, and/or are absent from the home due, for example, to incarceration or death. Our group and collaborators have begun this work across various settings where attachment disruption occurs (see Sharp & Marais, 2022, https://www.routledge.com/Growing-Up-Resilient-The-Mediational-Intervention-for-Sensitizing- Caregivers/Sharp-Marais/p/book/9780367703585).

PI_NAMEs: SHARP, CARLA  (contact)

PROGRAM_OFFICER_NAME: CAMPBELL-ROSEN, HOLLY RENEE

PROJECT_TERMS: 11 year old;Address;Adolescence;Adolescent;Africa South of the Sahara;Age;Aging;Articulation;Books;Caregivers;caregiving;Cessation of life;Characteristics;Child;Child Development;Child Mental Health;Chronic Disease;civil society;Climate;Cluster randomized trial;Code;Communities;community advisory board;community empowerment;community organizations;comparative;comparison intervention;Consolidated Framework for Implementation Research;cost effective;cost effectiveness;cost-effectiveness evaluation;Development;Diagnostic;Dimensions;disability;Disability Evaluation;disability-adjusted life years;disorder risk;Education;Effectiveness;Environment;Epidemic;evidence base;Family;feasibility trial;Feedback;Female;Focus Groups;follow-up;Funding;Future;Goals;Government;high risk;HIV/AIDS;Home;Home environment;Human Resources;implementation cost;implementation evaluation;Implementation readiness;Imprisonment;improved;informant;Infrastructure;Intervention;intervention effect;Malnutrition;Manuals;Measures;Mediating;Mediator;Mental Health;Methodology;Methods;Names;National Institute of Mental Health;neglect;Orphan;Outcome;Parents;Positioning Attribute;post intervention;Poverty;Prevention;programs;Psychology;Psychopathology;Public Health;public health intervention;public health relevance;Quasi-experiment;Randomized;Randomized, Controlled Trials;Readiness;recruit;Research;Research Domain Criteria;resilience;Resource-limited setting;response;Risk;Risk Factors;scale up;severe mental illness;skills;Social Processes;South Africa;State Government;Structure;substance abuser;Symptoms;System;Testing;therapy design;Uganda;Underserved Population;United States National Institutes of Health;Universities;uptake;Work;World Health Organization

PROJECT_TITLE: MISC-CBO: A cluster randomized control trial to improve the mental health of OVC in South Africa


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: Project Narrative Digital health interventions offer the potential to increase access to evidence-based interventions in low- resource settings and increase equity in mental health service for traditionally underserved populations. This project evaluates the implementation of a digital mental health platform with a focus on the use of peer supporters to increase scalability and sustainability and overcome workforce shortages for Limited English Proficiency Latinx patients.

PI_NAMEs: AGUILERA, ADRIAN ;SCHUELLER, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: MARRO, MARY ACRI

PROJECT_TERMS: Address;Anxiety;Attitude;Behavioral;behavioral health;burden of illness;Caring;Climate;Clinic;clinic ready;Cognitive Therapy;common treatment;cost comparison;cost effective;Country;Data;design;digital;digital delivery;digital health;digital intervention;digital mental health;digital treatment;Disparity;Effectiveness;effectiveness evaluation;effectiveness/implementation trial;efficacious treatment;Eligibility Determination;Equity;Evaluation;evidence base;Evidence based intervention;Evidence based practice;experience;Focus Groups;Future;General Hospitals;Goals;Hand;Health;health care settings;health equity promotion;Health Personnel;Health Resources;Health system;Healthcare Systems;Human;implementation evaluation;implementation strategy;improved;innovation;Internet;Intervention;Interview;Knowledge;Language;Latinx;Leadership;Limited English Proficiency;Linguistics;Measures;Mediator;Medicaid;medical specialties;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Methods;mobile computing;Modality;Modeling;Outcome;outreach;Patient Care;patient engagement;patient registry;Patients;peer;peer support;Population;Population Heterogeneity;Primary Care;primary care clinic;primary care provider;primary outcome;Process;Provider;psychologic;Public Health;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Registries;relative cost;Research;Resource-limited setting;Resources;safety net;San Francisco;secondary outcome;Site;skills;social;Spanish;standard of care;Surveys;Symptoms;System;Technology;Testing;Therapeutic Intervention;Time;trial comparing;Underserved Population;Uninsured;United States;uptake;Work

PROJECT_TITLE: SUPERA: Supporting Peer Interactions to Expand Access to Digital Cognitive Behavioral Therapy for Spanish-speaking Safety-Net Patients in Primary Care

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Rare Diseases

ORG_CITY: COLLEGE STATION

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: PROJECT NARRATIVE  Nuclear pore complexes (NPCs) mediate the extensive trafficking of proteins and RNAs between the cytoplasm and the nucleus of eukaryotic cells and thereby act as a central control point in numerous cellular processes. The proposed work will identify the pathways utilized by protein cargos as they migrate through the NPC's permeability barrier. This work is important for understanding how nucleocytoplasmic partitioning in cells and tissues is generated and maintained as well as for establishing a sound foundation upon which to develop treatments for a wide range of human diseases.

PI_NAMEs: MUSSER, SIEGFRIED M (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: 3-Dimensional;Address;Affinity;Algorithms;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Behavior;Binding;Binding Sites;Biochemical;Biocompatible Materials;Biological;Biophysics;Carrier Proteins;Cell Nucleus;Cell Physiology;Cells;Central Pore of the Nuclear Pore Complex;Chickens;Color;Complex;Cytoplasm;Dedications;Defect;density;design;Devices;Diameter;Diffusion;Disease;Environment;Eukaryotic Cell;Filtration;flexibility;Fluorescence Microscopy;Foundations;Functional disorder;Gatekeeping;Gene Expression;Genes;Glycine;Goals;Grant;Growth;Health;Heterogeneity;Human;human disease;Huntington Disease;imaging approach;Imaging technology;improved;Individual;Infrastructure;insight;leukemia;Link;Location;macromolecule;Malignant Neoplasms;Maps;Mediating;Membrane Proteins;migration;millisecond;Modeling;nanomechanics;nanoscale;Nature;new technology;Nuclear Envelope;Nuclear Pore;Nuclear Pore Complex;Nucleic Acids;nucleocytoplasmic transport;Nucleoplasm;Outcome;particle;Pathway interactions;Pattern;Peripheral;Permeability;Phenylalanine;Play;polypeptide;Positioning Attribute;preference;Primary biliary cirrhosis;Process;Property;Protein translocation;protein transport;Proteins;receptor;Research;Resolution;response;Ribonucleoproteins;RNA;Role;Route;scaffold;Shapes;Signal Transduction;Signal Transduction Pathway;single molecule;small molecule;sound;Structure;superresolution imaging;superresolution microscopy;Surface Properties;System;Technology;temporal measurement;Testing;Three-Dimensional Imaging;Time;Tissues;tool;Transportation;ultra high resolution;Visualization;Work

PROJECT_TITLE: Mapping Transport Pathways through Nuclear Pores using 3D Super-Resolution Microscopy

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Pediatric;Rare Diseases

ORG_CITY: AUSTIN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE All vertebrate cells make a complex cellular structure—essential for embryonic development—called the cilium, defects in which underlie congenital birth defects known as ciliopathies. Many ciliopathies, including OralFacial-Digital syndrome, Joubert syndrome, Meckel-Gruber syndrome, and the 100% lethal Short Rib Polydactyly, arise from mutations in genes that are critical for proper cilia formation, but which are nonetheless still poorly characterized. As ciliary proteins do not act in isolation, but instead function within larger multi- protein assemblies, this proposal takes an innovative, integrated approach to understanding ciliary protein complexes by combining cutting edge proteomic approaches with in vivo cell biology and computational modeling of protein structures to understand the mechanisms by which these genes work together to properly form cilia, and how specific mutations in these genes lead to birth defects.

PI_NAMEs: MARCOTTE, EDWARD M;WALLINGFORD, JOHN B (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Alleles;Apical;base;Biochemical;Biogenesis;Biological Assay;Biological Models;Biology;brain tract;Carrier Proteins;Cell Physiology;Cells;Cellular biology;Cellular Structures;Central Nervous System;Chlamydomonas;Cilia;ciliopathy;cilium biogenesis;Classification;Clinical;Collaborations;comparative;Complement;Complex;Computer Models;Congenital Abnormality;crosslink;Data;Data Set;Defect;Development;digital;Disease;Docking;Electron Microscopy;Embryonic Development;Etiology;Europe;experimental study;Face;Family suidae;fluid flow;Future;Generations;Genes;Genetic;Goals;Grant;Human;human disease;Human Genetics;Image;In Vitro;in vivo;Infant Mortality;innovation;insight;intercellular communication;Joubert syndrome;Kidney;kinetosome;Knowledge;Lead;Limb structure;Link;Maps;Mass Spectrum Analysis;Measures;Meckel-Gruber syndrome;Mediating;Medical Genetics;Microtubules;model organism;Modeling;mouse genetics;Mutation;novel;Oral;Organ;Organelles;Organism;Pattern;Polydactyly;Process;protein complex;protein structure;Proteins;Proteome;Proteomics;recruit;reproductive tract;rib bone structure;Role;Sampling;Skeleton;Structural Models;Structure;success;superresolution microscopy;Surface;Syndrome;Testing;Tetrahymena;three-dimensional modeling;Tissues;Trachea;Tubular formation;Variant;Work;Xenopus

PROJECT_TITLE: Mapping the ciliary interactome, an extensive protein interaction network underlying human ciliopathies

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative Annual flu and recent COVID-19 infection cause extensive destruction of alveolus structures, and inappropriate regeneration leads to prolonged inflammation and pulmonary diseases including fibrosis. Here, we use a combination of mouse models, organoid culture, single-cell analysis and pharmaceutical reagents to address how the chemosensory tuft cells are involved in lung regeneration following viral infection. The proposal will provide novel insights into fundamental mechanisms with broad scientific and clinical implications.

PI_NAMEs: QUE, JIANWEN  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: 2019-nCoV;Ablation;acute infection;Acute Lung Injury;Address;Alternative Therapies;Alveolar;Alveolar Cell;alveolar epithelium;Alveolus;antagonist;Attenuated;Basal Cell;Brush Cell;Cations;Cell Differentiation process;cell type;Cells;Chemosensitization;Chronic Disease;Clinical;Coronavirus;COVID-19;COVID-19 pandemic;COVID-19 pandemic effects;COVID-19 patient;cytokine;Data;Death Rate;directed differentiation;Disease;Distal;efficacy testing;Epithelial Cells;Exhibits;experimental study;Fibrosis;Financial Hardship;flu;Foundations;Genetic;Genetic Transcription;Goblet Cells;Health;helminth infection;Hyperplasia;Impairment;improved;In Situ Hybridization;Infection;Inflammation;Influenza;Influenza A Virus, H1N1 Subtype;influenza infection;insight;Intestines;Knock-in Mouse;Ligands;Lung;lung development;Lung Diseases;lung injury;lung regeneration;Mediating;Metaplasia;Modeling;Molecular;mouse model;Mucous body substance;Mus;Natural regeneration;notch protein;novel;novel strategies;novel therapeutic intervention;Organoids;Oxides;paracrine;Pathway interactions;Peripheral;Persons;Pharmacologic Substance;Phase;Play;Pod cells;pulmonary function;Reagent;receptor;repaired;Role;SARS-CoV-2 infection;seasonal influenza;Sensory;Signal Transduction;single cell analysis;stem cells;Structure;Structure of parenchyma of lung;targeted treatment;Testing;therapeutic target;Tissues;triphenylphosphine;TRPM5 gene;Virus;Virus Diseases

PROJECT_TITLE: Improve Lung Regeneration Through Targeting Tuft Cells Following Viral Infection

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Clinical Research;Colorectal Cancer;Complementary and Integrative Health;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: LA JOLLA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative  We will develop a platform for bacterial synthetic biology in complex, heterogeneous environments, using tumors as a model. We will develop genetic tools that allow bacteria to sense, respond to, and compensate for the tumor environment, as well as experimental techniques to monitor their dynamics using in vitro organoid models and animal models of hepatocellular carcinoma and colorectal cancer. Given that some bacteria can naturally localize to tumors, this synthetic biology platform will set the stage for engineering bacterial cancer biosensors and therapies.

PI_NAMEs: HASTY, JEFF M (contact);TSIMRING, LEV S;ZARRINPAR, AMIR

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: Affect;Anaerobic Bacteria;Animal Model;Bacteria;Bacterial Genes;Behavior;Biological Models;Biosensing Techniques;Biosensor;Cancer Model;CCL21 gene;clinically relevant;Colon;Colonoscopy;Colorectal;Colorectal Cancer;Colorectal Neoplasms;Compensation;Complex;CRISPR/Cas technology;Cues;Cytolysis;Data;design;design and construction;Development;Disease;Drug Delivery Systems;drug production;effectiveness study;Engineered Probiotics;Engineering;Environment;environmental change;Escherichia coli;Future;Gases;Gel;Gene Cluster;Gene Expression;Genes;Genetic;Genome;genome wide screen;genome-wide;Glucose;Goals;Growth;Growth Factor;Harvest;Health;High Fat Diet;high resolution imaging;Histology;Human;Human body;human disease;Hypoxia;Image;Imaging technology;Immunologic Surveillance;improved;In Situ Hybridization;In Vitro;in vivo;in vivo Model;Intercellular Fluid;Intestines;Liquid substance;Liver;liver cancer model;Luciferases;luminescence;Maintenance;Malignant Breast Neoplasm;malignant mouth neoplasm;Malignant neoplasm of gallbladder;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Methods;Microbe;microbial;Microfluidic Microchips;microfluidic technology;Microscopy;Modeling;Molecular;Monitor;mouse model;Mucous Membrane;Mus;neoplastic;nonalcoholic steatohepatitis;novel;Nutrient;Optical reporter;Oral;Organoids;Pathologic;Penetration;Play;Population;Population Dynamics;pre-clinical;preference;Primary carcinoma of the liver cells;Probiotics;promoter;Property;quorum sensing;Reaction;Reporting;Research;Resected;Resolution;response;Role;Safety;screening;Solid Neoplasm;Specificity;Spottings;Structure;synthetic biology;System;Techniques;Technology;Testing;Time;Tissues;tool;tumor;tumor growth;tumor microenvironment;Ultrasonography;ultrasound;Vesicle;Visualization

PROJECT_TITLE: Design and characterization of bacterial population dynamics in solid tumor models

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Neurodegenerative;Pediatric;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Capillary malformation (CM), the most common type of vascular malformation, is a congenital lesion that causes significant disfigurement and morbidity. The lesion worsens over time and is managed with laser or surgery. Drugs do not exist to treat CM and are desperately needed to prevent its progression and recurrence following laser and surgery. The experiments proposed in this application will generate in vitro and in vivo models to identify and test drugs that could potentially be used to treat CM.

PI_NAMEs: VIVERO, MATTHEW P (contact)

PROGRAM_OFFICER_NAME: SAMEDY BATES, LESLY

PROJECT_TERMS: Adenoviruses;Adult;Affect;Alleles;Angiopoietin-2;Animal Model;Animals;anti-epileptic agents;Appearance;Applications Grants;Area;Biological;Biological Assay;Birth;Blindness;Blood capillaries;Blood Vessels;bone;Brain;candidate identification;Cells;Clinical Trials;Clothing;Color;Complementary DNA;CRISPR/Cas technology;Cutaneous;Deformity;Diffuse;Dose;drug candidate;drug testing;Dyes;Eating;Embryo;Endothelial Cells;Endothelium;Enterobacteria phage P1 Cre recombinase;Excision;experimental study;Eye;Face;FDA approved;fetal;Fluorescence;functional disability;Functional disorder;Future;G alpha q Protein;Genes;Genetic;Glaucoma;GNAQ gene;Goals;Green Fluorescent Proteins;Growth;Hemorrhage;Heterotrimeric G Protein Subunit;high throughput screening;Histologic;Human;human disease;Impairment;In Vitro;in vivo;in vivo Model;Individual;Infant;Injectable;Injections;Intervention;Laboratories;Lasers;Lesion;Libraries;Life;Limb structure;malformation;Methods;Modeling;Molecular;Morbidity - disease rate;mouse model;Mus;mutant;Mutation;Neurologic;Newborn Infant;Nodule;Operative Surgical Procedures;Oral;overexpression;Pain;Pathogenesis;Pathway interactions;Patients;pediatric drug development;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Phospholipase;Physiologic pulse;PIK3CA gene;Port-Wine Stain;postnatal;Pre-Clinical Model;Preclinical Testing;prenatal;prevent;promoter;protein expression;Proteins;psychosocial;Recurrence;Safety;screening;Seizures;Site;skeletal;Skin;small molecule;soft tissue;Sturge-Weber Syndrome;System;Tamoxifen;Telomerase;Testing;Therapeutic Uses;Time;TNFSF5 gene;Translating;venule;Virus;Walking;Work

PROJECT_TITLE: Drug Development for Pediatric Capillary Malformation


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Social Determinants of Health

ORG_CITY: STANFORD

ORG_DEPT: SURGERY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The time of hospitalization is an under-utilized opportunity for intervention, whereby uninsured patients can obtain sustainable Medicaid insurance coverage through Hospital Presumptive Eligibility (HPE) programs which can in turn improve patients’ long-term healthcare access, clinical outcomes, and financial health. Our prior NIMHD-funded R21 work identified modifiable patient and system level barriers, amplified in minority groups, that inhibit successful Medicaid sustainment after HPE approval. Our current proposal involves mixed- methods analysis of these factors to guide development of a stakeholder-informed toolkit providing hospitals and county policy-makers with evidence-based strategies to reduce insurance-based disparities at the clinical point of care, particularly among minority racial and ethnic groups.

PI_NAMEs: KNOWLTON, LISA MARIE  (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: Accident and Emergency department;Adult;American;Black race;California;Caring;Case Study;Characteristics;Clinical;Collaborations;cost;Counseling;County;Data;Data Set;Death Rate;Development;Disadvantaged;Discipline;Disease;Disparity;effectiveness/implementation trial;Eligibility Determination;Emergency Situation;Enrollment;Ethnic Population;evidence base;Factor Analysis;Feedback;Focus Groups;follow-up;Funding;Future;Geography;Goals;Health;health care availability;health care service;health disparity;Health Expenditures;health service use;Health Services;Health Services Accessibility;Health system;Healthcare;Hispanic;Hospital Personnel;Hospitalization;Hospitals;implementation study;Improve Access;improved;Individual;innovation;Inpatients;Insurance;Insurance Coverage;Intervention;Interview;Investigation;Job loss;Knowledge;Left;Location;Logistic Regressions;Medicaid;Medical;Mental Health;Methods;Minority Groups;minority patient;Modeling;National Institute on Minority Health and Health Disparities;novel;Operative Surgical Procedures;Outcome;participant enrollment;Patients;point of care;Policy Maker;programs;racial minority population;Rehabilitation therapy;Resources;response;Sampling;Site;Social Work;sociodemographics;Solvents;Spanish;Specialist;Structure;success;system-level barriers;Testing;Time;Training;Uncompensated Care;Underinsured;Uninsured;usability;Work

PROJECT_TITLE: Increasing Medicaid Acquisition and Sustainment among the Uninsured

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE Bacterial pathogens in the genus Rickettsia cause serious human diseases, including spotted fever and typhus. The proposed work seeks to fill fundamental gaps in our knowledge of key virulence mechanisms used by Rickettsia as they mobilize or disrupt host cell components to promote escape into the cytoplasm, avoid intracellular elimination, and undergo intracellular motility and spread. These studies may reveal new mechanisms of host-pathogen interactions and new approaches for diagnosing and treating infections.

PI_NAMEs: WELCH, MATTHEW D (contact)

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TITLE: Mechanisms of Rickettsia invasion, intracellular survival, and actin-based motility

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

PHR: PROJECT NARRATIVE Bile acids, which are essential for regulating lipid and glucose metabolism, come in many different varieties. Changing the composition of bile acids in the body has numerous metabolic consequences, but it is unknown how these changes occur. This grant investigates the underlying processes by which bile acid composition regulates lipid and glucose metabolism.

PI_NAMEs: HAEUSLER, REBECCA ANNE (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: absorption;Acids;Adipocytes;Adipose tissue;Adult;Affect;Bile Acids;Biological Models;blood glucose regulation;blood lipid;Cannulations;Carbon;Cell Separation;cell type;Cells;Chylomicrons;Closure by clamp;Complement;CYP8B1 gene;Data;Diet;Disease;Enterocytes;Enzymes;extracellular;Family;fatty acid oxidation;Fatty Acids;Fatty Liver;Fructose;Genetic;Glucose Clamp;glucose metabolism;GPBAR1 gene;Grant;Health;High Fat Diet;Homeostasis;Human;humanized mouse;Hydroxylation;Hyperinsulinism;improved;In Vitro;in vivo;Individual;Infusion procedures;Insulin;Insulin Resistance;insulin sensitivity;insulin signaling;Intestinal Absorption;Intestines;Knock-out;lipid biosynthesis;lipid metabolism;Lipids;Lipolysis;Liver;liver metabolism;Lymph;Measures;Mediator;Mesentery;Metabolic;Metabolic Diseases;Metabolism;Methods;Molecular;mouse model;muricholic acid;Mus;Nonesterified Fatty Acids;Pathogenesis;Persons;pharmacologic;Physiological;Physiology;Play;Positioning Attribute;Process;Production;Property;receptor;Regulation;Research;response;Signal Transduction;Site;success;System;Tissues;tool;Tracer;uptake;Very low density lipoprotein;Work

PROJECT_TITLE: Bile acid composition and insulin sensitivity

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Digestive Diseases;Major Depressive Disorder;Mental Health;Mental Illness;Microbiome;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Chronic stress is a major risk factor for gastrointestinal disorders, such as irritable bowel syndrome (IBS), and psychiatric illnesses, such as major depressive disorder (MDD), with these two disorders showing high rates of co-morbidity. Potentially underlying this co-morbidity is the direct connection between the gut and brain known as the gut-brain axis, and the recent discovery that stress induces whole-body inflammation, which has been associated with both IBS and MDD. In this project, I will characterize how the brain and gut communicate during psychological stress to elicit gut inflammation, leaky gut, and depressive behaviors.

PI_NAMEs: CHAN, KENNY  (contact)

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: Ablation;afferent nerve;Animals;Anti-Inflammatory Agents;avoidance behavior;Bacterial Toxins;Behavior;Behavioral;Biological;Brain;Brain imaging;Brain region;Cells;Central Nervous System;Chronic;Chronic stress;Circulation;Colon;Colonic inflammation;Communication;comorbidity;Corticotropin-Releasing Hormone;depressive behavior;detection platform;Disease;Dopamine-beta-monooxygenase;Emotional;Endotoxemia;Endotoxins;Enteral;Enteric Nervous System;Environment;Etiology;Exhibits;experimental study;Female;Fiber;Flow Cytometry;Functional disorder;Functional Gastrointestinal Disorders;Gastrointestinal Diseases;Genes;Genetic;genetic manipulation;gut bacteria;gut inflammation;gut-brain axis;Human;Hypothalamic structure;Immunology;Inflammation;Inflammatory;intestinal barrier;Intestinal permeability;Intestines;Irritable Bowel Syndrome;Leaky Gut;Leukocytes;Link;mad itch virus;Major Depressive Disorder;male;Maps;Mediating;Mental Depression;Mental disorders;migration;Modeling;Mus;Neural Pathways;Neuroimmune;Neurons;Neurosciences;paraventricular nucleus;Pathway interactions;Peripheral;Permeability;Phenotype;Photometry;Process;Psychological Stress;Psychosocial Stress;Reporting;Risk Factors;Rodent Model;Sensory;Severities;Signal Transduction;social;social defeat;Stress;stress related disorder;Surrogate Markers;Sympathectomy;Symptoms;systemic inflammatory response;T-Lymphocyte;Techniques;Tight Junctions;Tissues;Tracer;Viral;Wild Type Mouse

PROJECT_TITLE: Brain-gut interactions regulating stress-related gut inflammation and barrier permeability

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: CA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Digestive Diseases;Esophageal Cancer;Prevention;Rare Diseases

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: RICE UNIVERSITY

PHR: Project Narrative/ Public Health Relevance Statement Esophageal cancer is the 6th leading cause of cancer death worldwide, and when diagnosed at a late stage, 5-year survival rates for esophageal adenocarcinoma are dismal (∼18%). While standard endoscopic screening for Barrett’s esophagus (precursor to adenocarcinoma) improves outcomes, it is expensive, requires sedation, expertise and infrastructure not available in many underserved or lower resource settings. Given the limitations of existing screening tools and the dismal mortality of EAC when diagnosed late, there is a substantial need for a cost-effective, community-based screening modality that can be used by non-expert clinicians without patient sedation to screen for Barrett’s.

PI_NAMEs: ANANDASABAPATHY, SHARMILA ;RICHARDS-KORTUM, REBECCA R. (contact)

PROGRAM_OFFICER_NAME: WU, YICONG

PROJECT_TERMS: accurate diagnosis;Adenocarcinoma;Algorithms;Barrett Esophagus;Barrett's neoplasia;Blood capillaries;Brazil;Cancer Detection;Cancer Etiology;capsule;Cessation of life;China;chromoscopy;Clinical;clinical decision-making;Collaborations;Communities;Community Practice;comparative;Computer software;cost;cost effective;Data;Databases;Deglutition;design;Detection;Development;Devices;Diagnosis;diagnostic criteria;digital;Disinfection;Dissection;Early Diagnosis;Early treatment;Electronics;Endoscopes;Endoscopy;Engineering;Esophageal Adenocarcinoma;Esophageal Neoplasms;Esophagogastric Junction;Esophagus;Evaluation;ex vivo imaging;experience;Family suidae;Feedback;Gastrointestinal tract structure;Goals;High grade dysplasia;high risk population;Histopathology;Human;human study;hypopharynx;IACUC;Image;Image Analysis;imaging approach;imaging capabilities;improved;improved outcome;in vivo evaluation;Infrastructure;Injections;Injury;Institutional Review Boards;Lateral;lens;Light;Lighting;Malignant neoplasm of esophagus;Malignant Neoplasms;Maps;Modality;Molds;mortality;Movement;Mucous Membrane;multidisciplinary;Neoplasms;Operative Surgical Procedures;Optics;Patients;Performance;pill;Pilot Projects;porcine model;portability;Process;Provider;public health relevance;recruit;Resected;Resolution;Resource-limited setting;Retrieval;Rice;Rotation;Rural;Safety;Sampling;Scanning;Schedule;screening;Screening for cancer;Screening procedure;Sedation procedure;sensor;Side;Specimen;standard of care;Stomach;Submucosa;Support System;Surface;Survival Rate;System;Tablet Computer;Technology;Testing;Time;Tissues;tool;Translations;transmission process;two-dimensional;underserved area;United States;Visualization;Work

PROJECT_TITLE: Low Cost Tethered Capsule Endoscope with High-Resolution Digital Chromoscopy for Barrett's Screening

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE A mechanistic and quantitative understanding of gene regulation in individual cells is essential for a better understanding, and ultimately treatment, of diseases. This project combines the development of single-cell multiomic approaches with human in vitro models and powerful tools for genetic manipulation to identify transcriptional and epigenetic mechanisms that regulate differentiation and development in human tissues and diseases.

PI_NAMEs: POTT, SEBASTIAN  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Biological Models;Biomedical Research;Cell Differentiation process;cell type;Cells;chronic inflammatory disease;Code;Development;Disease;Epigenetic Process;Gene Expression Regulation;Genes;Genetic;genetic manipulation;Genetic Transcription;Genome;Heterogeneity;Homeostasis;Human;human disease;Human Genome;human induced pluripotent stem cells;human tissue;in vitro Model;Individual;Malignant Neoplasms;Metabolic Diseases;multiple omics;Organism;Organoids;pathogenic microbe;Pathology;Process;response;Sampling;single cell genomics;Specific qualifier value;Stimulus;Technology;tool

PROJECT_TITLE: Mechanisms and determinants of dynamic gene regulation during development and cellular differentiation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-I(55)R]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: This proposal seeks to improve understanding of aging, brain aging and dementia specifically by expanding, modernizing and improving a longstanding cohort study of older adults enrolled from a healthcare delivery system with extensive records from clinical care. The Adult Changes in Thought (ACT) U19 Research Program has identified incident cases of dementia (>1,300 to date) and Alzheimer's disease (>1,000 to date) and follows consenting participants to autopsy (>850 to date). The U19 Program will provide valuable data on extremely well characterized individuals and aims to identify targets for prevention and treatment of Alzheimer's disease and other age-related disorders and facilitate greater collaborative research by expanding and improving dissemination of our exceptional resources.

PI_NAMEs: CRANE, PAUL K;LACROIX, ANDREA Z.;MCEVOY, LINDA KATHLEEN (contact)

PROGRAM_OFFICER_NAME: GHALEH, MARYAM X

PROJECT_TERMS: Accelerometer;Adopted;Adult;Affect;age-related disease;Aging;aging brain;aging related;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Anti-Cholinergics;Anti-Hypertensive Agents;Autopsy;Behavioral Sciences;Biological Assay;Biological Markers;Biology;Brain;Caregivers;Caring;Cause of Death;Cells;Cholinergic Agents;Clinical;clinical care;Clinical Data;clinical diagnosis;Clinical Research;Cognition;Cognitive;Cognitive aging;cognitive function;cognitive performance;cohort;Cohort Studies;Communities;Complex;Conceptions;Consent;Country;Data;data resource;Data Set;data sharing;Dementia;density;design;Development;Devices;Diabetes Mellitus;Diagnosis;Discipline;disorder subtype;Ecology;Economics;Enrollment;epidemiology study;ethnic diversity;Ethnic Origin;Etiology;Exercise;Family;follow-up;Foundations;Fright;Funding;Future;Glucose;Goals;Grant;health care delivery;high risk;Hour;Human;human old age (65+);Image;Impaired cognition;improved;Incidence;indexing;Individual;Influentials;interoperability;Intervention;Investigation;Investments;late life;Learning;Lewy Body Dementia;Life;Life Cycle Stages;Measures;Mentorship;Methods;Modernization;Movement;MRI Scans;National Institute on Aging;Nerve Degeneration;neural;Neurobehavioral Manifestations;neuroimaging;Neurons;neuropathology;older adult;Older Population;Outcome;Participant;participant enrollment;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;Phenotype;Physical activity;physical conditioning;Physical Function;Physical Performance;Policies;Positioning Attribute;preservation;Prevalence;prevent;Prevention;Process;programs;prospective;Prospective Studies;Prospective, cohort study;Race;Recording of previous events;Records;recruit;Reproducibility;Research;Research Personnel;resilience;resilience factor;Resources;Risk;Risk Factors;Sample Size;Science;Scientist;sedentary lifestyle;Senile Plaques;Series;sleep pattern;socioeconomic diversity;Specimen;stem cells;Subgroup;System;tissue resource;tool;Toxic effect;Visit;web site;Work

PROJECT_TITLE: Adult Changes in Thought (ACT) Research Program


NIH_SPENDING_CATS: Aging;Clinical Research

PI_NAMEs: JOHNSON, KATIEROSE  (contact)

PROJECT_TERMS: Accountability;Adult;Aging;Agreement;Alzheimer's disease related dementia;Ancillary Study;cohort;Collaborations;Communication;Communication Methods;Communities;Complex;Conflict (Psychology);Custom;Data;Data Aggregation;data dissemination;Data Set;data sharing;data standards;Dementia;Deposition;Documentation;Electronics;Enrollment;Ensure;Evaluation;experience;follow-up;Funding;Goals;hands-on learning;human subject;improved;Institution;International;Interview;Lead;Leadership;Life Cycle Stages;Logistics;Measurable;meetings;Modernization;National Institute on Aging;neuroimaging;neuropathology;Newsletter;older adult;Online Systems;operation;Outcome;Participant;Performance;Phenotype;Policies;Privatization;Procedures;Process;Productivity;Program Evaluation;programs;query tools;Reporting;repository;Research;Research Activity;Research Personnel;Research Project Grants;Resource Sharing;Resources;Risk Factors;Role;Science;Site;social media;Standardization;Structure;success;Surveys;symposium;timeline;Trust;Vertebral column;Vision;web site;webinar;Work

PROJECT_TITLE: Adult Changes in Thought (ACT) Research Program Core A: Administrative Core


NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Our brain function relies on the formation and maintenance of precise neural circuits among various subtypes of neurons, whose disruption contributes to many mental disorders including autism spectrum disorder. Neural circuits are mediated by synapses with distinct characteristics between neuronal subtypes and across developmental stages. Characterizing the diversity of synapses and elucidating the underlying developmental mechanisms will offer perspectives into how circuit specificity is established and how it goes awry in mental disorders.

PI_NAMEs: WANG, LI  (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Acute;Adaptive Behaviors;Affect;ARHGEF5 gene;autism spectrum disorder;Award;Behavior;Biology;Brain;Brain Diseases;career;cell type;Cells;Cerebral cortex;Characteristics;Chemical Synapse;Chromatin;Critical Pathways;critical period;Data;density;designer receptors exclusively activated by designer drugs;Development;developmental neurobiology;Disease;DNA Sequence Alteration;Epigenetic Process;Exhibits;experience;Foundations;Functional disorder;Future;Gene Expression;Gene Expression Profile;gene regulatory network;Genes;Genetic;Genetic study;Genetic Transcription;Glutamates;Goals;Heterogeneity;Human;in vivo;Individual;insight;Interneurons;knock-down;Knowledge;Label;Learning;Link;Long-Term Effects;Machine Learning;machine learning method;Maintenance;Mediating;Mental disorders;Mentors;Methods;Molecular;multiple omics;Mus;Mutation;neural circuit;Neurons;novel;Pathway interactions;Patients;Phase;Play;postsynaptic;postsynaptic density protein;Process;programs;Property;protein complex;Proteins;Proteome;Proteomics;Research;Research Project Grants;Resolution;Risk Factors;Rodent Model;Role;single cell genomics;single-cell RNA sequencing;skills;Solid;Specificity;Synapses;Synaptic plasticity;Synaptic Transmission;synaptogenesis;targeted treatment;Techniques;temporal measurement;Testing;tool;Training;Transcriptional Regulation

PROJECT_TITLE: Identifying mechanisms ofsynapse maturation at neuronal subtype resolution


PHR: Although severe asthmatics comprise only approximately 5% of all asthmatics, they utilize a significant amount of health care resources (approximately 40% of the estimated $50 billion direct costs of asthma/year in the USA). As airway remodeling in severe asthma can contribute to lower lung function and a greater decline in lung function, there is an important need to identify mechanisms by which airway remodeling is mediated so that potential novel therapies could be directed at these pathways. The UCSD AADCRC seeks to identify such novel therapeutic targets to inhibit airway remodeling and prevent decline in lung function in severe asthma.

PI_NAMEs: BROIDE, DAVID H (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Acute;airway inflammation;airway remodeling;Asthma;asthma exacerbation;asthmatic;Autopsy;Biological Markers;Biopsy;Blood Vessels;Bronchi;Bronchoconstrictor Agents;Bronchodilator Agents;Cells;Clinical;cytotoxic;Data;Direct Costs;Epithelial Cells;Epithelium;Extracellular Matrix;Family member;Fibroblasts;Fibrosis;Frequencies;Goals;Guidelines;Healthcare;Human;Immune;In Vitro;Inflammation;Inflammatory;Light;Lung;Mediating;Metaplasia;Molecular;Mucous body substance;muscle form;new therapeutic target;novel;novel therapeutics;Pathway interactions;Population;prevent;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Recommendation;Resources;respiratory smooth muscle;response;Rhinovirus infection;Sampling;T-Lymphocyte;Testing;Therapeutic;Thick;tissue resident memory T cell;TNF gene;United States National Institutes of Health;Viral

PROJECT_TITLE: Airway Inflammation and Airway Remodeling in Severe Asthma


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Back Pain;Congenital Structural Anomalies;Genetics;Pain Research;Pediatric

ORG_DEPT: DENTISTRY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative The broad, long-term goal of this project is to develop a comprehensive understanding of both the specification of the cell identity and the regulatory network that regulates the formation and patterning of the intervertebral disc, which plays a pivotal role in spinal function and is subject to developmental disease, degenerative disease, and injury. Currently, there is no treatment to stop or reverse the progress of the intervertebral disc degeneration. Successful completion of this proposal will considerably increase our understanding of how cell identity is specified during formation of the intervertebral discs, and will provide the foundation for future studies to regenerate this tissue in degenerative disc disease.

PI_NAMEs: ZHANG, CHENGHAI  (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Adolescent;Adult;Affect;Aging;antagonist;arthropathies;articular cartilage;Binding;Binding Sites;Cartilage;cartilage cell;cell type;Cells;Chondrocytes;Chromatin;Chronic low back pain;Complex;Congenital Camptodactyly;Congenital Scoliosis;Connective Tissue;cortical bone;Degenerative Disorder;Development;developmental disease;disability;Disease;DNA Binding Domain;Engineering;Enhancers;Exons;Facet joint structure;Fibrocartilages;Follow-Up Studies;Foundations;Future;Genes;Genetic;genome wide association study;Goals;Hip region structure;Idiopathic scoliosis;Individual;inhibitor;Injury;Intervertebral disc structure;intervertebral disk degeneration;Japan;joint formation;Knockout Mice;Kyphosis deformity of spine;Location;Longterm Follow-up;Lordosis;loss of function mutation;Low Back Pain;lubricin;Mesenchymal;Modulus;Molecular;morphological criteria;Morphology;Movement;Mus;Musculoskeletal;Natural regeneration;neuromuscular;nucleus pulposus;Operative Surgical Procedures;Patients;Pattern;Pericarditis;Play;progenitor;promoter;pup;Regulatory Element;Role;Rotator Cuff;Sclerotome;scoliosis;Shock;Signaling Molecule;Specific qualifier value;Spinal;Spinal Diseases;stem;stem cells;Surface;Susceptibility Gene;Syndrome;Synovial joint;Tendon structure;Testing;Thinness;tissue regeneration;Tissues;tool;transcription factor;transcriptome;vertebra body;Vertebral column;Work

PROJECT_TITLE: Elucidation of the role of Creb5 in promoting the formation and patterning of the intervertebral disc

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: MCEVOY, LINDA KATHLEEN (contact)

PROJECT_TERMS: Address;Adult;African American population;Aging;Alzheimer's Disease;Area;Autopsy;Calibration;Characteristics;Clinic;Clinic Visits;Clinical;Cognition;cognitive testing;cohort;Collaborations;Communication;Companions;Consent;County;Data;Data Collection;data collection site;data exchange;data sharing;data standards;Dementia;dementia risk;design;digital;Documentation;Elements;Eligibility Determination;Enrollment;Ensure;ethnic diversity;ethnic minority;Ethnic Origin;Family;follow-up;Geography;Goals;Health Status;Home;Home visitation;improved;Individual;Infrastructure;Investments;Life;Maps;Methods;Minority Enrollment;Modernization;Moods;neuropathology;new technology;older adult;Participant;Physical Function;population based;Populations at Risk;Procedures;Process;programs;Quality Control;Race;racial diversity;racial minority;Randomized;repository;Research;Risk Factors;Sampling;Social status;sociodemographics;sound;Time;Underrepresented Minority;Visit;Washington;Work

PROJECT_TITLE: Adult Changes in Thought (ACT) Research Program Core B: Clinical Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

PI_NAMEs: TOM, SARAH ELIZABETH (contact)

PROJECT_TERMS: Adherence;Adult;adverse childhood events;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Anti-Hypertensive Agents;Area;Autopsy;Birth;Blood Pressure;blood pressure reduction;Brain;built environment;caregiving;Censuses;cerebrovascular;Clinical;clinical care;Cognition;Cognitive;cognitive function;cohort;Collection;college;Communities;Data;Data Aggregation;Data Collection;Data Files;data sharing;Data Sources;Dementia;dementia risk;Development;Disparate;econometrics;Economics;electronic data;Electronics;Employment;Enrollment;ethnic diversity;experience;Future;Geography;Goals;Government;Growth;Head circumference;Health;health care delivery;health data;Health Policy;Healthcare;Hypertension;Impaired cognition;improved;Individual;Influentials;Injury;innovation;Integrated Delivery of Health Care;Intervention;Investigation;late life;Leadership;Life;Life course epidemiology;Life Cycle Stages;Longitudinal cohort;Measures;Mediating;Medical Records;middle age;Modernization;Neurologic;Neurosciences;Occupations;older adult;Outcome;Paper;Participant;Pattern;Pharmaceutical Preparations;Physical activity;Prevention;programs;Public Domains;Questionnaires;racial diversity;Recording of previous events;Records;Research;Research Personnel;Resources;Risk;Role;Science;Scientific Inquiry;social;social determinants;Social Environment;Social Network;Socioeconomic Status;socioeconomics;Source;Subgroup;Surveys;System;Testing;Time;United States;Variant;Washington;Work

PROJECT_TITLE: Adult Changes in Thought (ACT) Research Program Core C: Life Course Core


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Bioengineering;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative Exposure to air pollution consistently ranks among the leading global causes of illness and death. This project will develop a low cost wearable system to continuously assess personal exposure to airborne fine and ultrafine particulates at high spatial and temporal resolutions, leading to more effective interventions to reduce personal exposures and improving overall public health.

PI_NAMEs: DVONCH, JOSEPH TIMOTHY;MASON, ANDREW J (contact);ZENG, XIANGQUN

PROGRAM_OFFICER_NAME: CUI, YUXIA

PROJECT_TERMS: Aerosols;Air;air monitoring;Air Pollutants;Air Pollution;Airborne Particulate Matter;assessment application;atmospheric aerosols;Biological;Carbon;Cessation of life;Chemicals;Classification;Communities;community health study;Community Health Systems;Complex;cost;cost effective;Data;Data Set;design;Development;Devices;Diameter;effective intervention;Elements;Environment;Environmental Health;Evaluation;evaluation/testing;Exposure to;field study;fine particles;Fractionation;Goals;Grant;Health;health data;health disparity populations;health management;Heterogeneity;Humidity;improved;Individual;Infrastructure;innovation;Intervention;Life Style;Link;Liquid substance;Location;Measures;Methods;microelectronics;Microfluidic Microchips;Microfluidics;microsystems;miniaturize;miniaturized device;Modeling;Monitor;mortality;Nature;novel;particle;particle counter;Particulate Matter;pathogen;Phase;pollutant;Pollution;portability;Public Health;Public Health Applications Research;public health intervention;Real-Time Systems;Reporting;Research;Resolution;Risk;Sampling;smart device;software development;Spatial Distribution;spatiotemporal;Surface;System;Techniques;Technology;Temperature;temporal measurement;Time;tool;Trace Elements;Trace metal;Ultrafine;ultrafine particle;urban area;wearable device

PROJECT_TITLE: Wearable Microsystem for Continuous Personalized Aerosol Exposure Assessment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-V(02)M]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Palliative Care;Social Determinants of Health

ORG_CITY: BIRMINGHAM

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Many of the estimated 37 million U.S. adults living with Chronic Kidney Disease (CKD) rely on unpaid family and friend caregivers to assist with disease management and navigate health-related decision-making. However, a significant gap in the literature highlights the necessity to develop and test interventions designed to train patients with CKD and their caregivers to be activated members of the shared decision-making team. This project aims to equip CKD patients and their caregivers with the skills needed to be activated members in shared decision-making before illness advances.

PI_NAMEs: GAZAWAY, SHENA  (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Adult;advanced disease;Anxiety;Biopsy;Black race;burden of illness;care preference;Caregivers;caregiving;Caring;Chronic Kidney Failure;Clinical Trials;Communication;Conflict (Psychology);coping;Creatinine;Data;Data Collection;Decision Making;design;Dialysis procedure;Diet and Nutrition;Disease;Disease Management;Distress;Doctor of Philosophy;dyadic interaction;Educational Intervention;Educational workshop;Effectiveness;end of life;Equation;Equipment and supply inventories;Ethics;Exclusion;expectation;experience;Family;Family Caregiver;Family member;family support;Friends;Future;Glomerular Filtration Rate;Goals;Health;Hospitals;Human Subject Research;improved;Individual;Intervention;intervention refinement;Interview;Kidney Diseases;Kidney Transplantation;Knowledge;Literature;Measures;Medical;meetings;member;Mental Depression;Mentorship;multiphase optimization strategy;National Institute of Diabetes and Digestive and Kidney Diseases;Newly Diagnosed;Outcome;Participant;Patient Education;Patients;perceived discrimination;Persons;Pharmaceutical Preparations;pilot test;Population;post intervention;primary outcome;Protocols documentation;psychoeducation;Quality of life;Race;racial disparity;Randomized;recruit;Regimen;Reporting;Research;Resources;Sampling;Scientist;secondary outcome;shared decision making;skills;Social support;Statistical Data Interpretation;symposium;systematic review;telehealth;Testing;therapy design;therapy development;Training;Training Support;Trust;Vision;Work

PROJECT_TITLE: An Optimization trial of a stakeholder-enhanced intervention to improve the decisional partnership of Chronic Kidney Disease dyads using the multiphase optimization strategy: Project ImPart.

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: KEENE, CHRISTOPHER DIRK (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Adult;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease therapeutic;Autopsy;biobank;Biochemical;Biological;Biological Assay;Biological Markers;biomarker discovery;Blood Glucose;Body Fluids;Brain;Brain region;brain research;brain tissue;Cell Line;cell type;Cells;Clinical;Cognitive;cohort;Collaborations;Communities;Consensus;Data;data quality;data sharing;deep learning;Dementia;design;Development;Diagnostic;Diagnostics Research;Dissection;Ensure;Equipment and supply inventories;Fostering;Foundations;Functional disorder;Funding;Genetic;Gifts;Goals;Growth;Guidelines;Heterogeneity;Human;Image;Image Analysis;Imaging technology;Immunoassay;in silico;Individual;innovation;Investments;Knowledge;Leptomeninges;Life Cycle Stages;Liquid substance;loved ones;Magnetic Resonance Imaging;Measures;Methods;Microscopic;Molecular;Natural History;Nerve Degeneration;Nervous System Trauma;neuroimaging;neuroinflammation;neuropathology;Neurosciences;neurotoxicity;non-demented;novel;Participant;Pathologic;Pathologic Processes;Pathology;Peptides;Persons;Pharmacotherapy;Phase;Process;Productivity;programs;prospective;Proteins;Protocols documentation;Psychometrics;Publications;quantitative imaging;radiological imaging;Recommendation;reconstruction;Recording of previous events;Reporting;repository;Research;Research Activity;Research Personnel;Research Subjects;Research Support;resilience;Resistance;Resources;Sampling;Scanning;Science;Sectioning technique;Slide;Specimen;Therapeutic Research;tissue fixing;Tissues;United States National Institutes of Health;Variant;virtual

PROJECT_TITLE: Adult Changes in Thought (ACT) Research Program Core D: Neuropathology Core


ADMINISTERING_IC: DE

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Gene Therapy;Genetics;Orphan Drug;Rare Diseases

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE We have identified microRNA-27a* (miR-27a*) as a regulator of epidermal growth factor receptor and other critical signaling pathways frequently overexpressed in head and neck squamous cell carcinoma (HNSCC), and strongly correlated with poor patient survival. The successful completion of these studies would not only contribute to fundamental knowledge regarding the role of novel and potentially druggable miR-27a* targets in the progression of HNSCC, but also comprehensively evaluate the potential therapeutic effect of reintroducing miR-27a* in cancer cells using an innovative ultrasound-triggered microbubble delivery system. Our ability to validate miR-27a* as a therapeutic agent with an effective means of delivery to tumors will impact clinical practice by providing an urgently needed cornerstone to current multimodality therapy for HNSCC.

PI_NAMEs: LAI, STEPHEN Y (contact);VILLANUEVA, FLORDELIZA S

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Address;Affect;AKT1 gene;antitumor effect;Apoptosis;Biological;Biological Assay;Biological Process;cancer cell;cancer diagnosis;Cell Death;Cell Line;Cell Survival;Cetuximab;chemotherapy;Cisplatin;Clinical;clinical implementation;clinical practice;clinical translation;combat;combinatorial;Combined Modality Therapy;Contracts;craniofacial;Critical Pathways;Data;Dental;Development;Disease;Disease Progression;drug use screening;effective therapy;EGFR Protein Overexpression;Endocytosis;Engineering;Epidermal Growth Factor Receptor;Evaluation;Family;FRAP1 gene;Future;Genes;Goals;Head and Neck Squamous Cell Carcinoma;Health;Histone Deacetylase;image guided;improved;improved outcome;in silico;In Vitro;in vitro Assay;in vivo;inducible gene expression;inhibitor;innovation;Intravenous;Knowledge;Malignant Neoplasms;Mediating;Mediator;Methods;Microbubbles;microRNA delivery;MicroRNAs;Mission;Modeling;Molecular;Molecular Target;mouse model;multimodality;Mus;National Institute of Dental and Craniofacial Research;neoplastic cell;novel;novel therapeutic intervention;novel therapeutics;oligonucleotide delivery;Oncogenes;Oncogenic;Oral;Outcome;overexpression;Pathogenesis;Pathway interactions;Patients;Pre-Clinical Model;prevent;Process;Proteins;Proto-Oncogene Proteins c-akt;Publishing;Radiation;Regulation;Repression;Research;RNA;RNA Degradation;RNA delivery;Role;Safety;Sampling;screening;Signal Pathway;Site;Small Interfering RNA;Specimen;standard of care;Survival Rate;System;targeted agent;targeted delivery;targeted treatment;Testing;theranostics;Therapeutic;Therapeutic Agents;Therapeutic Effect;Therapeutic Intervention;therapeutic RNA;Therapeutic Uses;Tissue Sample;Tissues;Tongue Neoplasms;Toxic effect;Translating;treatment optimization;Treatment Protocols;tumor;tumor growth;tumor progression;Tumor Promotion;Tumor Tissue;Ultrasonic Therapy;ultrasound

PROJECT_TITLE: Development of miR-27a* for the Treatment of Head and Neck Squamous Cell Carcinoma

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Neurosciences

PI_NAMEs: MACDONALD, CHRISTINE L (contact)

PROJECT_TERMS: 3-Dimensional;Adult;aging brain;aging process;Archives;Artificial Intelligence;artificial intelligence method;Autopsy;Brain;brain magnetic resonance imaging;brain tissue;California;Cessation of life;Clinical;Cognitive;cohort;Collaborations;Collection;Communities;Complex;Data;Data Science;Dementia;Funding;Future;Genetic;Human;Image;Image Enhancement;image guided;imaging science;imaging study;improved;in vivo;Individual;Knowledge;Laboratories;Lesion;Life;longitudinal analysis;Machine Learning;Magnetic Resonance Imaging;member;Methods;Modernization;MRI Scans;Neurobiology;neuroimaging;Neurology;neuropathology;Neurosciences;neurosurgery;novel;older adult;Participant;Pharmacoepidemiology;Pharmacy facility;Procedures;Process;programs;Protocols documentation;quantitative imaging;Records;Research;Research Personnel;Research Support;Resolution;Sampling;Scanning;serial imaging;Sleep;Structure;Subgroup;synergism;Techniques;Testing;Time;Tissue Sample;Tissues;tool;Universities;Visualization;Work

PROJECT_TITLE: Adult Changes in Thought (ACT) Research Program Core E: Neuroimaging Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Brain Disorders;Clinical Research;Data Science;Dementia;Neurosciences

PI_NAMEs: WALKER, ROD  (contact)

PROJECT_TERMS: Address;Adult;Aging;aging brain;Alzheimer's Disease;Autopsy;Behavior;Biological;Biometry;Biostatistical Methods;Blood;Brain;Censuses;Clinic;Clinical;Clinical Data;Cognition;Cognitive;Cohort Studies;Collaborations;Consult;Country;Custom;Data;Data Collection;Data Element;Data Files;data infrastructure;data integration;data integrity;data management;data resource;Data Science;Data Scientist;Data Set;data sharing;Data Sources;data streams;Databases;Dementia;Diagnosis;Disease;disorder subtype;Documentation;Electronic Health Record;Ensure;epidemiology study;Evaluation;experience;Feedback;Foundations;Funding;Generations;Genotype;Goals;Health;Health Care Visit;Heterogeneity;Home;Hour;Image;improved;Informatics;innovation;Interdisciplinary Study;interest;Investments;Knowledge;Laboratories;Leadership;Life Cycle Stages;Link;Manuscripts;member;Methodology;Methods;monitoring device;neuroimaging;neuropathology;novel;older adult;Outcome;Participant;Pattern;Pennsylvania;Pharmaceutical Preparations;physical conditioning;Physical Function;Play;Polysomnography;Positioning Attribute;Procedures;Process;programs;Qualifying;query tools;Readiness;Recording of previous events;repository;Reproducibility;Reproducibility of Results;Research;Research Design;Research Personnel;Research Project Grants;Research Proposals;Resources;Role;Scientific Evaluation;Secure;Security;Site;Source;Standardization;Statistical Data Interpretation;Statistical Methods;Structure;success;Surveys;System;Technical Expertise;Time;tool;Translating;Universities;usability;user-friendly;Washington;Wisconsin;Writing

PROJECT_TITLE: Adult Changes in Thought (ACT) Research Program Core F:  Data and Analysis Core


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

PHR: Project Narrative The goal of the Molecular and Cellular Immunobiology training program is to attract a diverse and talented group of predoctoral students and provide them with cutting-edge training leading to a PhD in Immunology. The field of Immunology is increasingly recognized as important in a broad range of human diseases. A cadre of well- trained, innovative young Immunologists is essential to achieve a basic understanding of the immune system, and to successfully develop new diagnostics and therapies for immune-related diseases.

PI_NAMEs: MARTINEZ, OLIVIA M (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Immunobiology;Molecular

PROJECT_TITLE: Molecular and Cellular Immunobiology

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Neurosciences;Physical Activity;Prevention;Rehabilitation;Sleep Research

PI_NAMEs: ROSENBERG, DORI E (contact)

PROJECT_TERMS: Accelerometer;actigraphy;Activities of Daily Living;Activity Cycles;Adult;adverse childhood events;age effect;age related;Age-associated memory impairment;Aging;aging related;Alzheimer's Disease;Beds;Behavior;Behavioral;Brain;Cardiovascular Diseases;Circadian Rhythms;Clinical;Cognition;Cognitive;cognitive ability;cognitive function;cohort;Collaborations;Collection;comorbidity;Complement;Complex;Data;Data Collection;data resource;Dementia;Development;Devices;diaries;Education;Energy Metabolism;Equilibrium;executive function;functional independence;Future;Gait speed;Goals;Guidelines;Hand Strength;Health;healthy aging;Heterogeneity;Hour;Image;immune function;Impaired cognition;improved;Income;Individual;Information Systems;innovation;instrument;Intervention;Joints;late life;Life;Life Cycle Stages;Magnetic Resonance Imaging;Maintenance;Measurement;Measures;Metabolic syndrome;Modeling;Monitor;Mood Disorders;neuroimaging;neuropathology;novel;older adult;Outcome;Participant;Patient Outcomes Assessments;Patient Self-Report;Pattern;Phase;Physical activity;Physical assessment;physical conditioning;Physical Function;Population;programs;Research;Resources;response;Risk;Risk Reduction;screening;sedentary lifestyle;sex;Sleep;sleep behavior;Sleep disturbances;sleep quality;Testing;theories;Thigh structure;Time;verbal;vigorous intensity;Work;Wrist

PROJECT_TITLE: Physical activity, sedentary behavior, and sleep in the ACT cohort: The 24-hour activity cycle


ORG_CITY: ATHENS

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Project Narrative This study will investigate the molecular and cell biological mechanisms behind chromosome-specific recombination events in Drosophila melanogaster, which will provide insight into the proper segregation of chromosomes during meiosis in higher organisms. Additionally, this work has the potential to identify the importance of chromosome structure in meiotic chromosome behaviors, which has implications for infertility.

PI_NAMEs: BILLMYRE, KATHERINE ELISABETH (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Address;Affect;Aneuploidy;arm;autosome;Behavior;Biological;Biology;Cells;Cellular biology;Centromere;chromosome missegregation;Chromosome Pairing;Chromosome Segregation;Chromosome Structures;Chromosomes;Congenital Abnormality;Cytology;Defect;Development;Developmental Biology;Diploidy;DNA;Drosophila genus;Drosophila melanogaster;egg;Embryo;Etiology;Event;Exhibits;experience;Failure;Female;Fertility Disorders;Genetic;Genetic Crossing Over;Genetic Nondisjunction;Genetic Recombination;Genome;genome sequencing;Germ Cells;Goals;Haploidy;high resolution imaging;Human;In Situ Hybridization;Individual;Infertility;insight;Location;loss of function;Meiosis;Meiotic Recombination;model organism;Modeling;Molecular;mutant;novel;offspring;Oocytes;Organism;Pattern;Process;programs;Proteins;Regulation;Research;Resolution;Ribosomal DNA;Role;Sampling;segregation;sperm cell;Sterility;Structure;Synaptonemal Complex;System;Techniques;Time;Training;Trisomy;Visualization;whole genome;Work;X Chromosome

PROJECT_TITLE: Uncovering mechanisms controlling chromosome-specific behaviors during meiosis

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Mental Health

ORG_DEPT: PSYCHIATRY

PHR: Project Narrative: Research training of clinically trained mental health researchers is particularly important in order to advance our understanding and treatment of mood, eating, and anxiety disorders, that are all extremely common and are often associated with great morbidity. Interdisciplinary research can help advance our understanding of these disorders and aid in prevention and treatment. Developing basic, clinical, and translational research skills is vital to achieve these goals.

PI_NAMEs: MANBER, RACHEL ;RODRIGUEZ, CAROLYN I;SCHATZBERG, ALAN F. (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TITLE: A Biobehavioral research Training Program


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Precision Medicine

PI_NAMEs: CRANE, PAUL K (contact)

PROJECT_TERMS: 3-Dimensional;Academic Medical Centers;Address;Adult;Alzheimer's Disease;Alzheimer's disease diagnosis;Artificial Intelligence;Atrophic;Autopsy;Braak's hypothesis;Brain;Brain imaging;Brain region;Caregivers;Categories;cerebral atrophy;Clinic;Clinical;clinical heterogeneity;Cognition;Cognitive;cognitive testing;cohort;Communities;Data;deep learning;Diagnosis;digital;disorder subtype;economic implication;Economics;Evolution;executive function;Family;Genetic;Goals;Guidelines;Heterogeneity;hippocampal atrophy;Image;improved;Infrastructure;innovation;Investigation;Knowledge;Language;Late Onset Alzheimer Disease;Left;Life;Life Cycle Stages;Malignant Breast Neoplasm;Malpractice;Measurement;Medical Records;medical specialties;Memory;Modality;Modeling;MRI Scans;Natural History;Nerve Degeneration;neuroimaging;neuropathology;Outcome;Pathologic;Pattern;Performance;personalized medicine;Persons;precision medicine;Process;programs;regional atrophy;regional difference;Research;Research Personnel;Resources;Sampling;Scanning;Scourge;Side;Slice;Slide;Staging;Structure;Subgroup;success;tau Proteins;Testing;Time;Visuospatial;Woman

PROJECT_TITLE: Cognitively Defined Alzheimer's Subgroups: Natural history, neuropathology, and life course ramifications


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Immunization;Infectious Diseases;Lyme Disease;Prevention;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative No methods currently exist to predict who will and will not fully recover from Lyme disease, or to explain why at least 10% of people experience persistent symptoms following antibiotic treatment. Here, we propose to evaluate a new biomarker and technology we developed for predicting which patients are on a trajectory to recover by profiling patient immune reactions. Investigating immune markers may identify a cause of some of the persistent symptoms experienced by patients, potentially leading to better clinical trials and novel therapeutics aimed at preventing long term illness by helping the immune system respond more effectively. 1

PI_NAMEs: TAL, MICHAL CASPI (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Acute;Aftercare;Antibiotic Therapy;Antibiotics;Antibodies;antibody engineering;Bacteria;Binding;Biological Markers;Borrelia burgdorferi;Cell Degranulation;Clinical;clinical care;Clinical Trials;cohort;Complement Activation;Complex;Computer Analysis;cost efficient;Cross-Sectional Studies;Data;Development;Diagnosis;Disease;Disease Progression;Disease susceptibility;Dose;Engineering;Exhibits;experience;Flow Cytometry;Funding;Future;Goals;Heterogeneity;high risk;Human;Hypersensitivity;IgE;IgG1;IgG2;IgG3;IgG4;Immune;Immune response;Immune system;Immune System Diseases;Immunoglobulin A;Immunoglobulin G;Immunoglobulin M;Immunologic Markers;Immunologic Tests;immunoreaction;Individual;Infection;Inflammatory;innovation;Institutional Review Boards;Label;Lyme Disease;mast cell;Measures;Methods;Mouse Strains;Mus;new therapeutic target;novel;novel therapeutics;Participant;pathogen;Pathologic;Pathology;Patients;persistent symptom;Persons;Phagocytosis;Physicians;Plasma;predictive marker;Prevalence;prevent;prospective;Prospective Studies;Proteins;ratiometric;Recovery;Research;Research Proposals;research study;response;sample collection;Sampling;Scientist;Serology;Severity of illness;standard of care;Techniques;Technology;Testing;Therapeutic;tool;United States;Validation;Vector-transmitted infectious disease

PROJECT_TITLE: Unlocking serology’s secrets: harnessing novel immune biomarkers to predict Lyme disease progression and recovery


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Influenza;Lung;Neurosciences;Pneumonia and Influenza;Sleep Research

ORG_CITY: DALLAS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE – PUBLIC HEALTH RELEVANCE STATEMENT Circadian rhythms exert immense control over immunity, yet very little is known regarding how immune cells are regulated through entrainment pathways. We have discovered a key entrainment neurotransmitter receptor, the β2-adrenergic receptor, that is required for circadian-dependent T cell responses to viral infection. We will pursue this discovery by determining the role of Adrb2 in regulating circadian-dependent T cell responses to influenza infection in a mouse model, which will impact our understanding of time-of-day responses of humans to upper respiratory viral infections.

PI_NAMEs: FARRAR, JOHN DAVID (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Acceleration;Acute;adaptive immunity;ADRB2 gene;Adrenergic Agents;Adrenergic Receptor;anti-cancer;antiviral drug development;Area;ARNTL gene;Arrhythmia;beta-2 Adrenergic Receptors;Binding;Biological Clocks;Biological Process;CAR T cell therapy;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cells;circadian;Circadian Dysregulation;Circadian gene expression;Circadian Rhythms;Communicable Diseases;Cues;Darkness;Development;Disease;Effector Cell;effector T cell;Epinephrine;Exhibits;Frequencies;Gene Expression;Genes;Goals;Health;Human;human disease;Immune;Immune response;Immunity;improved;in vivo;Infection;Inflammation;Inflammatory;Influenza;Influenza A virus;influenza infection;interest;Jet Lag Syndrome;Light;light entrainment;lung injury;Mammals;Measures;Mediating;Modality;Molecular;mouse model;Mus;Nature;Neurons;Neurotransmitter Receptor;Neurotransmitters;Norepinephrine;Outcomes Research;pathogen;Pathway interactions;Peripheral;Phase;Physiology;Play;Property;public health relevance;Publishing;Pulmonary Inflammation;receptor;response;Role;Severity of illness;Signal Transduction;Sympathetic Nervous System;T cell response;T-bet protein;T-Cell Development;T-Lymphocyte;targeted treatment;Testing;Therapeutic Intervention;therapy design;Time;Tissues;Vaccine Design;Viral Pathogenesis;Viral Respiratory Tract Infection;Viral Vaccines;virtual;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Adrenergic control of circadian rhythms in CD8 T cells responding to influenza

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Hypertension;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: GRAY, SHELLY L (contact)

PROJECT_TERMS: Address;Adrenergic beta-Antagonists;Adult;Alzheimer's Disease;Amyloid beta-Protein;Angiotensin II;Angiotensin Receptor;Angiotensin-Converting Enzyme Inhibitors;Angiotensins;Anti-Cholinergics;anti-depressive agents;Anti-Hypertensive Agents;Antihistamines;Benefits and Risks;Biological;Biological Assay;Blood;Blood Pressure;Brain;brain health;brain volume;Cell Line;Cells;Cholinergic Agents;Chronic;cohort;Cohort Studies;comparative;comparative effectiveness;Complement;computerized;Data;Dementia;dementia risk;Development;drug testing;Drug usage;Engineering;Epidemiology;Exposure to;human induced pluripotent stem cells;human stem cells;In Vitro;Induced pluripotent stem cell derived human neuron;innovation;interest;Knowledge;Life course epidemiology;Link;Measurable;Measures;Medicine;Methodology;Methods;middle age;Modeling;Molecular;Nerve Degeneration;neuroimaging;Neurons;neuropathology;neuroprotection;neurotoxic;neurotoxicity;novel;Outcome;Participant;Pathologic;Pathway interactions;Pharmaceutical Preparations;Pharmacoepidemiology;population based;Positioning Attribute;programs;receptor;Regimen;Research;Resources;Risk;Science;Sedation procedure;standard measure;stem cell model;stem cells;Testing;Thiazide Diuretics;translational approach;United States National Academy of Sciences;urologic;Ventricular;White Matter Hyperintensity;Work

PROJECT_TITLE: Translational pharmacoepidemiology: neuroprotection and neurotoxicity of antihypertensives and strong anticholinergics


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative The development of new antibiotics requires a complete understanding of bacterial physiology and metabolism, particularly aspects that are unique to bacteria. We have discovered two unusual repeated sequences, called replication risk sequences or RRS, in the chromosome of Escherichia coli that play a demonstrably important role in DNA replication and cell division. As a new DNA structure that is conserved in many pathogens and unique to bacteria, a better understanding of RRS structure and function may lead to new approaches to the control of bacterial diseases.

PI_NAMEs: COX, MICHAEL M. (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Affect;Antibiotics;Bacteria;Bacterial Chromosomes;Bacterial Infections;bacterial metabolism;Bacterial Physiology;Biological Assay;Cell division;cell growth;Cells;Cellular biology;chromosome replication;Chromosome Segregation;Chromosomes;Databases;Defect;Deposition;design;Development;Diameter;Diffusion;Distant;DNA;DNA biosynthesis;DNA metabolism;DNA Structure;Elements;Enterobacteriaceae;Enzymes;Escherichia coli;experience;Future;Genes;Genetic;Genetic Recombination;Genetic Transcription;Genome;genomic locus;Genomics;Goals;Growth;In Vitro;in vivo;Interruption;Length;Measurable;meter;Methods;microbiological attachment sites;Microscopy;Molecular Biology;Nature;new technology;novel strategies;nucleic acid metabolism;pathogen;Physical condensation;Play;Positioning Attribute;prevent;Property;Protocols documentation;Rec A Recombinases;repaired;Reporting;Risk;Role;segregation;Side;single molecule;Single-Stranded DNA;Site;Stress;Structure;System;Time;transcriptome sequencing;Work

PROJECT_TITLE: Characterization of the RRS: a new chromosomal structural element in E. coli

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Hematology;Human Genome;Immunotherapy;Orphan Drug;Rare Diseases

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Thalidomide analogs are highly active drugs in the treatment of patients with multiple myeloma and other hematologic malignancies. While they have improved patient outcomes considerably, almost all patients eventually develop resistance to these agents. This project builds on prior mechanistic work to understand how resistance develops in patients and how we might overcome it.

PI_NAMEs: SPERLING, ADAM  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Advisory Committees;Affect;analog;Apoptosis;Binding;Biological Assay;Biology;Biometry;cancer cell;career;career development;Cell Line;Cell Separation;Cells;ChIP-seq;Clinical;clinical practice;clinically significant;cohort;Collaborations;Communities;Complex;CRISPR/Cas technology;Dana-Farber Cancer Institute;Development;Development Plans;Disease;Dose;Down-Regulation;Drug Targeting;Dysmyelopoietic Syndromes;Educational process of instructing;Environment;Epigenetic Process;experimental study;Genes;Genetic;genetic corepressor;Genetic Screening;Genetic Transcription;Glues;Goals;Growth;HDAC3 gene;Hematologic Neoplasms;Human;improved;In Vitro;Inflammatory;innovation;insight;International;Laboratories;lenalidomide;Lymphoma;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Measures;Mediating;Mediator;Medical;Mentorship;Methods;Molecular;Monitor;Multiple Myeloma;mutant;NCOR1 gene;new technology;novel;novel strategies;novel therapeutic intervention;Nuclear;Oncologist;Oncoproteins;Pathway interactions;Patient Care;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacodynamics;Physicians;Plasma Cells;pomalidomide;predictive marker;protein expression;Proteins;Proteomics;receptor;Research;Research Personnel;Resistance;Resistance development;resistance mechanism;response;response biomarker;retinoic acid receptor alpha;Role;Sampling;Scientist;Signal Transduction;small molecule;System;Technology;Thalidomide;Therapeutic;therapeutically effective;therapy resistant;Time;Training;transcriptome sequencing;Translating;Translational Research;treatment response;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;whole genome;Work

PROJECT_TITLE: Defining mechanisms of thalidomide analog resistance

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Immunotherapy

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: By establishing a new protocol to generate and maintain stable colonies of physiological microbe-exposed animals, the proposed research aims to examine the impact of physiological microbial exposure on regulatory T (Treg) cell-mediated immune regulation in health and disease conditions, these studies will provide critical insights into the possibilities and limitations of targeting Treg cells to treat a wide array of human immunological disorders.

PI_NAMEs: LU, LI-FAN  (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Ablation;animal care;Animal Experimentation;Animal Experiments;Animals;Antigens;autoimmune inflammation;Autoimmunity;Biological Assay;Biomedical Research;Cell Separation;Cellular biology;Chronic Disease;Clinical Trials;commensal microbes;Communities;comparative;Data;Dedications;Development;dietary;Disease;Environment;Exhibits;experience;Exposure to;Fostering;Foundations;Functional disorder;Funding Opportunities;Future;gain of function;Genetic;germ free condition;Germ-Free;Health;Heterogeneity;Homeostasis;Human;Immune;Immune response;Immune system;Immune System Diseases;Immune Tolerance;Immunity;Immunological Models;Immunologics;Immunology;Immunophenotyping;immunoregulation;In Vitro;in vivo;Inbreeding;Infection;Infectious Agent;Inflammation;insight;interest;Knowledge;Laboratories;Laboratory Animals;Laboratory mice;Location;loss of function;Lymphoid;Mediating;Microbe;microbial;microbiome;Modeling;mouse model;Mucosal Immune System;Mus;Nature;new therapeutic target;pathogen;Pathologic;Phenotype;Physiological;Pilot Projects;Population;pre-clinical research;preclinical study;prevent;programs;Protocols documentation;Recording of previous events;Regulatory T-Lymphocyte;Reliability of Results;Reporting;repository;Reproducibility;Reproducibility of Results;Research;Research Personnel;Role;Science;Shapes;Signal Transduction;single cell sequencing;Solid;Suppressor-Effector T-Lymphocytes;T cell therapy;T-cell receptor repertoire;Tissues;transcriptome;Viral;Work

PROJECT_TITLE: Investigate the impact of physiological microbial exposure on regulatory T cell-mediated immune regulation

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Machine Learning and Artificial Intelligence;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Existing heart disease and stroke prediction models (e.g., Framingham) tend to overestimate risk for Hispanics/Latinxs (H/L)s resulting in significant economic and public health impacts. There may be unique disease determinants for H/Ls that remain untested or unincorporated, which may deviate from traditional conceptualizations of cardiovascular disease (CVD) risk such as the role of culturally-moderated social capital. This project will inform prediction models and improve accuracy for H/Ls by identifying CVD risk and resilience factors using theory and data-driven methods to address knowledge gaps.

PI_NAMEs: FLORES, MELISSA ANN (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Address;Adopted;Adult;Algorithms;Arizona;Atherosclerosis;Behavior Therapy;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;career;Country;cultural values;Data;data reduction;Dimensions;Disease;disease disparity;Disease Outcome;Economics;Ethnic Population;Etiology;Exhibits;experience;Family;Foundations;Functional disorder;Future;Goals;Heart Diseases;High Density Lipoproteins;Hispanic Community Health Study/Study of Latinos;Hispanic Populations;Household;improved;Incidence;Intervention;Knowledge;Latino Population;Latinx;Literature;Machine Learning;machine learning algorithm;Measurement;Measures;Medical;Mentors;Methods;Mexican;model development;Modeling;Modification;mortality;Neighborhoods;Population;predictive modeling;Public Health;Research;Research Proposals;resilience;resilience factor;Resources;Risk;Risk Estimate;Risk Factors;risk prediction;risk prediction model;risk selection;Role;Sampling;social;social capital;Social Environment;Social Network;socioeconomics;Solid;Spouses;stem;Stroke;Testing;theories;Training;Universities;Validation;Work

PROJECT_TITLE: Toward Accurate Cardiovascular Disease Prediction in Hispanics/Latinos: Modeling Risk and Resilience Factors


NIH_SPENDING_CATS: Anorexia;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Eating Disorders;Mental Health;Mental Illness;Neurosciences;Nutrition;Serious Mental Illness;Telehealth

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE It has long been acknowledged that people with anorexia nervosa (AN) may get stuck in their eating disorder symptoms because of problems related to positive affect and reward: while weight loss becomes increasingly rewarding, the ability to experience pleasure or fulfillment from other experiences decreases, making it difficult to stop engaging in weight-loss behavior. However, no treatments have been designed to specifically interrupt this problematic pattern. In this study, we test whether a remotely-delivered psychosocial therapy designed to increase general positive affect and decrease weight-loss-related positive affect can and enhance treatment outcomes in the vulnerable post-acute period of AN.

PI_NAMEs: HAYNOS, ANN FRANCES (contact)

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: active control;Acute;Adult;Affect;Affective;affective neuroscience;Affective Symptoms;Ambulatory Care;Anorexia Nervosa;Anxiety;Anxiety Disorders;anxiety reduction;anxiety symptoms;associated symptom;Behavior;Behavior Therapy;Behavioral;biobehavior;Biological;Body mass index;Body Weight decreased;Calories;Caring;Clinical;cognitive task;Cognitive Therapy;comorbidity;comparison control;Control Groups;Cues;Data;Death Rate;depressive symptoms;design;Disease;Eating;Eating Disorders;Ecological momentary assessment;effective therapy;efficacious treatment;Excision;Exercise;Exhibits;experience;Feeling suicidal;follow-up;Food;Growth;Hospitals;improved;indexing;Individual;innovation;Innovative Therapy;Interruption;Intervention;Investigation;Knowledge;Literature;Maintenance;Measures;Mental Depression;Mental disorders;Modeling;Mood Disorders;Morbidity - disease rate;multimodality;National Institute of Mental Health;Neurocognitive;Neurosciences;novel;Outcome;Participant;Patient Self-Report;Patients;Pattern;Persons;Pilot Projects;Play;pleasure;Positive Valence;Process;programs;psychoeducation;psychosocial;Randomized;Randomized, Controlled Trials;rapid growth;Relapse;relapse risk;remote delivery;Research Domain Criteria;Residual state;Rewards;Role;Science;Social Interaction;Specialist;Starvation;suicidal;symptomatic improvement;Symptoms;System;Technology;Teletherapy;Testing;therapy design;Time;Translating;treatment as usual;Treatment outcome;Waiting Lists;Weight

PROJECT_TITLE: Neuroscience-informed treatment to remotely target reward mechanisms in post-acute anorexia nervosa


ORG_CITY: OXFORD

ORG_DEPT: CHEMISTRY

ORG_NAME: MIAMI UNIVERSITY OXFORD

ORG_STATE: OH

PHR: The molecular chaperone Grp94 plays an important role in facilitating proper folding of proteins in the endoplasmic reticulum. Failure to maintain proper folding results in various disease states, making Grp94 an attractive therapeutic target. Successful completion of this work will significantly increase our understanding about the fundamental structure and function relationship involved in the Grp94 chaperone mechanism.

PI_NAMEs: KRAVATS, ANDREA N (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: ATP Hydrolysis;Biological;Cardiovascular Diseases;Cell Survival;Cells;Client;computer studies;design;Development;dimer;Disease;Drug Design;Drug Targeting;economic value;Endoplasmic Reticulum;Equilibrium;Event;experimental study;Failure;Foundations;Hepatitis B;Hepatitis C;Individual;inhibitor;interest;Intervention;Knowledge;Malignant Neoplasms;Medical;Methods;misfolded protein;Mitochondria;Molecular;Molecular Chaperones;Molecular Conformation;Neurodegenerative Disorders;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;paralogous gene;Pathway interactions;Play;prevent;Productivity;protein folding;protein misfolding;Proteins;proteostasis;Research;Role;Sampling;Structure;Techniques;therapeutic target;tool;Toxic effect;Work

PROJECT_TITLE: Elucidating the Mechanistic Details of the Grp94 Molecular Chaperone through an Integrated Computational and Experimental Approach

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Dietary Supplements;Infectious Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: The fungus Candida albicans is the leading cause of oral candidiasis among immunocompromised individuals. While iron plays an important role in commensal to virulent switch for C. albicans colonization between the gut and the blood, the effect of iron levels in the oral cavity are unknown. This proposal will test how host iron levels affect the outcome of oral C. albicans infection; with the aim of understanding the mechanism of iron- mediated growth pattern of C. albicans in the oral cavity as well as the potential of host iron-modulating translation approaches to boost existing antifungal-treatment strategies.

PI_NAMEs: PURI, SUMANT  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Address;Affect;anti-fungal agents;antimicrobial;Architecture;beta-Glucans;Blood;Caenorhabditis elegans;Candida;Candida albicans;Candida auris;Candida glabrata;Cell Wall;Cells;Cellular Immunity;Chitin;Chromatin;Communication;cytokine;Data;Defense Mechanisms;diabetic;Drug resistance;drug sensitivity;Environment;experimental study;extracellular;fitness;fungus;Gene Expression;Genes;Glucans;Goals;Growth;Homeostasis;Human;Hyphae;Immune;Immune response;Immune system;Immunocompromised Host;immunogenic;In Vitro;in vivo;Individual;Infection;innate immune mechanisms;insight;Iron;Iron Chelating Agents;Iron Chelation;Iron Metabolism Disorders;iron supplementation;Iron-Dextran Complex;Life Style;Link;Macrophage;Mannans;Measures;Mediating;Microbial Biofilms;microbial colonization;Mitogen-Activated Protein Kinases;Modeling;Morbidity - disease rate;Morphogenesis;mortality;Mucous Membrane;Mus;Mycoses;neutrophil;novel;Nutritional Immunity;Oral;Oral candidiasis;Oral cavity;oropharyngeal thrush;Outcome;pathogen;Pathogenesis;Pattern;Persons;Phagocytes;Phagocytosis;Pharmaceutical Preparations;Play;Population;Predisposition;Production;Property;recruit;Repression;response;Role;Signal Induction;Signal Pathway;Signal Transduction;Signal Transduction Pathway;SLC11A2 gene;Structure;synergism;Testing;Tissues;Tongue;trait;Transcription Repressor;Transcriptional Regulation;translational approach;treatment strategy;Variant;Virulence;Virulent;Work;Yeasts

PROJECT_TITLE: Role of environmental iron in Candida albicans cell wall remodeling and its effect on host-pathogen interaction during oropharyngeal candidiasis

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]