NIH_SPENDING_CATS: Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: Public Health Relevance Section Transforming the process by which academic researchers, healthcare system leaders, clinicians, and other stakeholders (from patients to organizations) determine what research questions to ask is essential for addressing the health and healthcare needs of rural populations. This transformation is only possible with an infrastructure that supports involvement in the research identification, selection, implementation, and dissemination processes. This application seeks to build on the efforts of healthcare system located in a rural community in California to inform new approaches for supporting the knowledge transfer process through a clinical research network.

PI_NAMEs: AYALA, GUADALUPE X (contact);BELL, YVONNE

PROJECT_TERMS: Address;Advisory Committees;Award;Awareness;Birth Weight;Border Community;California;career;clinical practice;Clinical Research;clinical research site;Cohort Studies;Collaborations;Common Data Element;Communities;community advisory board;Complex;Computerized Medical Record;contextual factors;County;Data;Data Analyses;Data Collection;data harmonization;data sharing;data submission;Development;Disease;Education;Effectiveness;effectiveness trial;Ensure;Equity;Evaluation;Exclusive Breastfeeding;Family;follow-up;Fostering;Funding;Goals;Health;Health Disparities Research;health disparity;health equity;Health Personnel;Health Promotion;Healthcare;Healthcare Systems;Household;Human Resources;implementation efforts;Income;Infant;Infrastructure;infrastructure development;innovation;Institutional Review Boards;Interdisciplinary Study;Intervention;Knowledge;Lactation;Language;Logic;Maps;Medical center;member;Mental Health;Methods;Mexico;minority health;minority health disparity;Modeling;National Institute on Minority Health and Health Disparities;novel strategies;Obesity;Outcome;overweight child;Participant;Patients;Personal Satisfaction;Phase;Pilot Projects;Poaceae;Policies;Population;pragmatic trial;Prenatal care;Procedures;Process;programs;protocol development;Protocols documentation;Research;Research Infrastructure;Research Personnel;Research Priority;Research Support;Resources;response;Risk;Rural;Rural Community;Scientific Inquiry;secondary analysis;shared decision making;Site;social determinants;student participation;suburb;System;Testing;Time;timeline;U-Series Cooperative Agreements;Underserved Population;Weight

PROJECT_TITLE: Imperial County Clinical Research Network for Health Equity


ADMINISTERING_IC: MD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Liver Disease;Patient Safety;Primary Health Care;Social Determinants of Health

ORG_CITY: HONOLULU

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: Project Narrative This application will organize a local consortia of ambulatory primary care settings in Hawaii to form the Hawaii Clinical Research Network for Health Equity (HICRN-HE). The project will conduct 2 projects under the thematic health disparity problem of fatty liver disease.

PI_NAMEs: BALARAMAN, VENKATARAMAN ;SETO, TODD B;SHIKUMA, CECILIA M. (contact)

PROGRAM_OFFICER_NAME: OLADEINDE, YEWANDE A

PROJECT_TERMS: Address;Adherence;Age;Agreement;Cerebrovascular Disorders;Chronic Kidney Failure;chronic liver disease;Clinic;Clinical Research;clinical research site;Communities;comorbidity;Data;data enclave;data repository;Databases;Development;Diabetes Mellitus;Disease;Disease Management;Early Diagnosis;elastography;Electronic Health Record;Enrollment;Ensure;Ethnic Origin;Ethnic Population;Fatty acid glycerol esters;Fatty Liver;fatty liver disease;Federally Qualified Health Center;Filipino;gender minority group;General Population;Geography;Goals;Grant;Guidelines;Hawaii;Health;health care delivery;Health Disparities Research;health disparity;health equity;Health system;HIV;Homelessness;Indigenous;Infrastructure;Institutional Review Boards;interest;Island;life span;Link;Liver;Liver diseases;Liver Fibrosis;Logistics;Malignant Breast Neoplasm;Malignant neoplasm of lung;medically underserved population;Monitor;Native Hawaiian or Other Pacific Islander;non-alcoholic fatty liver disease;Obesity;Pacific Ocean;patient safety;Patients;Persons;Phase;Pilot Projects;Policies;Population;population based;Preparation;Prevalence;Primary Care;primary care clinic;primary care setting;Procedures;Process;Protocols documentation;Public Health;racial diversity;recruit;Registries;Research;Research Design;Research Personnel;Research Project Grants;Risk;Rural Community;Secure;Sexual and Gender Minorities;sexual minority group;System;Translational Research;Underinsured;Uninsured;Update;Vulnerable Populations

PROJECT_TITLE: HAWAII CLINICAL RESEARCH NETWORK FOR HEALTH EQUITY


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Emergency Care;Health Services;Neurodegenerative;Palliative Care;Patient Safety;Physical Injury - Accidents and Adverse Effects

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Most surgery for seriously ill older adults, including persons living with dementia (PLWD), is unplanned or emergent, rather than elective, and surgery for hip fracture is among the most common. Given the high frequency of unplanned surgery in this population, high palliative care needs, and adverse outcomes such as increased healthcare use, complications, and mortality after surgery, it is imperative to investigate the frequency of, health outcomes associated with, and factors affecting, palliative care delivery during care for unplanned surgical illness. Building on our current studies of palliative care in elective surgery, these supplemental studies will provide an innovative and layered examination of palliative care's role in unplanned surgical care for hip fractures among seriously ill older adults, with a specific focus on PLWD.

PI_NAMEs: COOPER, ZARA R (contact)

PROGRAM_OFFICER_NAME: KELLER, CHANDRA

PROJECT_TERMS: Accident and Emergency department;Acute;acute care;Admission activity;Adult;adverse outcome;Affect;Area;care delivery;care outcomes;Caregiver Burden;Caregivers;Caring;Clinic;cohort;Communities;Complement;contextual factors;Data;Dementia;Dementia caregivers;design;Documentation;Elderly;electronic health data;Electronic Health Record;Emergency Care;Emergency department visit;Emergency Situation;Ethnography;experience;Face;Family Caregiver;Frequencies;Funding;Future;Goals;Grant;Health;health care service utilization;Health system;Healthcare;Healthcare Systems;high risk;Hip Fractures;hip surgery;Home;hospice environment;hospice utilization;Hospitals;human old age (65+);improved;Individual;Informed Consent;Injury;innovation;inpatient service;Inpatients;insight;Investigation;Knowledge;Link;medical specialties;Medicare claim;Methodology;mortality;mortality risk;Natural Language Processing;New England;nursing home length of stay;older adult;older patient;Operative Surgical Procedures;Outcome;palliative;Palliative Care;parent grant;Patient-Focused Outcomes;Patients;Persons;Population;Postoperative Care;Procedures;Process;Proxy;repaired;Research;Resources;Retrospective cohort;Risk;Role;Shapes;shared decision making;Testing;United States;United States National Institutes of Health;ward;Work

PROJECT_TITLE: A Layered Examination of the Patient Experience to Elucidate the Role of Palliative Care in Surgical Care for Seriously Ill Older Adults

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cancer;Dementia;Genetics;Neuroblastoma;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ATLANTA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE Alzheimer's disease (AD) is the primary cause of dementia, making up about 70% of cases worldwide, and thus the therapeutic strategies to ameliorate the clinical symptoms are urgently needed. This project aims to restore the neuroprotective and anti-inflammatory TGFb-SMAD signaling in AD using novel SMAD4 PPI inducers.

PI_NAMEs: MO, XIULEI  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: abeta deposition;Abeta synthesis;Alzheimer's Disease;Alzheimer's disease patient;Amyloid;Amyloid beta-Protein;Anti-Inflammatory Agents;Astrocytes;Behavior Disorders;Binding;Biological Assay;Brain;Cell membrane;Cell model;Cells;Clinical;clinically significant;Complex;cytokine;Defect;Dementia;Development;Disease;Epithelial Cells;Event;executive function;Functional disorder;Gene Expression;Genetic Polymorphism;Genetic Transcription;global health;Glues;Growth;Homeostasis;human induced pluripotent stem cells;hyperphosphorylated tau;immunoregulation;Impaired cognition;Impairment;Induced pluripotent stem cell derived human neuron;Inflammatory;inflammatory milieu;innovation;Lead;Luciferases;MADH3 gene;MADH4 gene;Mediating;Memory impairment;Microglia;migration;Modeling;Molecular;Neuroblastoma;Neurodegenerative Disorders;neurofibrillary tangle formation;Neurofibrillary Tangles;Neuroimmune;neuroinflammation;Neuronal Differentiation;Neuronal Injury;neuronal survival;Neurons;neuroprotection;novel;novel therapeutic intervention;Nuclear;Organoids;Pathogenesis;Pathologic;Pathologic Processes;Phagocytosis;Phenotype;Phosphorylation;Process;Production;protein protein interaction;receptor;Regulation;Reporter;Risk;Sensorimotor functions;Signal Transduction;Smad Proteins;small molecule;Speech;Symptoms;Synapses;targeted treatment;tau Proteins;Testing;TGFB1 gene;Therapeutic;Transforming Growth Factor beta;Visuospatial

PROJECT_TITLE: Activation of TGFb signaling using novel SMAD4 molecular glues

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Prevention

ORG_CITY: PROVIDENCE

ORG_NAME: BUTLER HOSPITAL (PROVIDENCE, RI)

ORG_STATE: RI

PHR: Markers of Alzheimers Disease can be found in the blood (amyloid-beta (Aβ), phosphorylated tau (pTau), and neurofilament light (NfL)). Our objective is to describe levels of these markers in the blood, and factors that influence levels of these biomarkers, among a group of older adults living with HIV who do not exercise regularly. Our findings will inform dementia prevention and diagnosis in older adults living with HIV.

PI_NAMEs: BAKER, JASON V;UEBELACKER, LISA A (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: Accounting;activity marker;Administrative Supplement;Affect;Age;aged;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid beta-42;Amyloid beta-Protein;Behavior Therapy;Behavioral;Biological Markers;Blood;Cerebrospinal Fluid;Characteristics;Clinical;Clinical Research;cognitive function;cognitive testing;cohort;Data;Dementia;dementia risk;design;Diagnosis;Disease;exercise intensity;Fibrin fragment D;frailty;HIV;Impaired cognition;Impairment;improved;Inflammation;Inflammatory;inflammatory marker;Interleukin-6;Intervention;Life;Life Style;Light;modifiable risk;neurofilament;neuroinflammation;novel;older adult;Older Population;Parents;Participant;Persons;Phenotype;Physical activity;Physical assessment;Physical Function;physical inactivity;Physical Performance;Plasma;Population;Prevention;primary outcome;Randomized;recruit;Research;Risk Marker;risk prediction model;systemic inflammatory response;tau-1;Testing;Time

PROJECT_TITLE: Optimization of a behavioral intervention to increase physical activity in older adults living with HIV


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Chronic Pain;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Pain Research

ORG_CITY: GAINESVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Our recent cross-sectional findings suggest that chronic pain is associated with multiple biological aging biomarkers where a greater pain burden is associated with accelerated aging processes. Thus, the goal of the proposed study is to determine the brain and bodily aging mechanisms whereby pain prospectively impacts function in aging and whether these are different across racial/ethnic groups. Findings will contribute towards increased understanding of pain and biological aging processes, with the potential to reduce race/ethnic group disparities and improve pain-related health outcomes.

PI_NAMEs: CRUZ-ALMEIDA, YENISEL  (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: Acceleration;Address;age acceleration;Aging;aging biomarker;aging brain;aging mechanism;aging process;Alzheimer's disease related dementia;Biological Aging;Blood;Brain;brain tissue;chronic pain;Clinical;Cognition;Cognitive deficits;Dementia;Diagnosis;Dimensions;Disparity population;epigenetic aging;epigenetic marker;Ethnic Population;experience;Goals;Health;human old age (65+);Impaired cognition;improved;Individual;Link;Literature;Magnetic Resonance Imaging;neurobiological mechanism;Outcome;Pain;Persons;Phase;pre-clinical;prospective;racial population;Reporting;Research;Risk Factors;Tissues;Validation;verbal;Work

PROJECT_TITLE: Supplement-Discovery and Validation of Epigenetic Biomarkers in Brain Tissue

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(02)-M]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Women's Health Research

ORG_CITY: HANOVER

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE Our project aims to refine a novel Near-infrared Spectral Tomography (NIRST) system for probing whether changes in tumor vasculature predict early neoadjuvant chemotherapy (NAC) responses. The rigor of prior re- search and the human data we obtained show the normalized change in tumor hemoglobin (ΔHbT %) after the first NAC cycle is a key indicator for classifying Residual Cancer Burden, with significant results in multi-class Receiver Operating Curve analysis (an area under the curve of 0.80). We will focus on the new technology developments that will elevate NIRST from a research tool to a fully functional clinical solution.

PI_NAMEs: JIANG, SHUDONG  (contact)

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: 3-Dimensional;Adjuvant Chemotherapy;Adoption;advanced breast cancer;Agreement;Area Under Curve;Belief;Biological Markers;Biophysics;Birth;Blood Vessels;Breast;Breast Cancer Patient;breast density;breast imaging;breast scan;Cancer Burden;cancer imaging;cancer subtypes;chemotherapy;Classification;Clinic;Clinical;Clinical Oncology;Clinical Research;Clinical Trials;Collaborations;contrast imaging;Contrast Media;cost;Data;data acquisition;deep learning;Dependence;design;Detection;detection platform;detector;Diagnostic;diffuse optical spectroscopy and imaging;Diffusion;Disease-Free Survival;Ensure;ERBB2 gene;Extracellular Matrix;Face;Feasibility Studies;Fiber;flexibility;Frequencies;Funding;Future;Grant;Hemoglobin;human data;Image;Image Enhancement;image reconstruction;imaging modality;imaging platform;imaging system;Imaging technology;improved;inflammatory breast cancer;Infrastructure;Infusion procedures;insight;interest;Ionizing radiation;Lasers;Light;Magnetic Resonance Imaging;Mainstreaming;Malignant Breast Neoplasm;Mammary Neoplasms;Mammography;Methods;Modification;Neoadjuvant Therapy;new technology;novel;Oncology;optical imaging;Outcome;Pathologic;Patient-Focused Outcomes;Patients;Performance;Persuasive Communication;Phase;portability;Positioning Attribute;Positron-Emission Tomography;predictive marker;Procedures;Prognostic Marker;Property;Publishing;Relaxation;Research;Residual Cancers;response;Risk;Safety;Shapes;Signal Transduction;stem;Surface;survival outcome;System;technological innovation;Technology;technology development;Therapy trial;Three-Dimensional Image;Time;Tissue imaging;Tissues;tomography;tool;Toxic effect;treatment response;tumor;Tumor Volume;ultrasound;United States National Institutes of Health;wearable device;Woman;Work

PROJECT_TITLE: 3D wearable NIR spectral tomography for early prediction of breast cancer’s residual cancer burden after neoadjuvant chemotherapy

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative True to our laboratory’s goals of creating a CRISPR-analogous system for proteome editing, we will develop both the algorithmic and experimental tools to bind and modify target proteins in a programmable fashion. To do this, we will complement our recent peptide-guided degrader system (a protein “off” switch) with a newly-engineered peptide-guided deubiquitinase system for target protein stabilization (a protein “on” switch). To enable design of these highly-specific, programmable peptide-guided editors, we will further establish algorithms that prioritize mutant-specific peptides, and train new models that capture post-translational modification information, motivating design of peptides that bind specific post-translational protein states to selective modulate modified disease-causing proteins versus their wild-type healthy counterparts.

PI_NAMEs: CHATTERJEE, PRANAM  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Aging;Algorithms;Amino Acid Sequence;Amino Acids;Architecture;Area;ART protein;Binding;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;design;Deubiquitination;Diffusion;Discrimination;Disease;Engineering;Enzymes;Generations;generative artificial intelligence;genome editing;Goals;Huntington gene;Investigation;KRAS2 gene;Laboratories;Language;Malignant Neoplasms;Masks;Modeling;mutant;Oncogenic;Pathogenicity;Peptides;Phosphorylation;Post-Translational Protein Processing;Process;Property;protein degradation;Protein Isoforms;Proteins;Proteome;Research;SwissProt;System;Technology;tool;Training;ubiquitin isopeptidase;ubiquitin-protein ligase;Validation;Variant;Work

PROJECT_TITLE: Towards the Design of Programmable, Isoform-Selective Proteome Editing System

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Firearms Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Unintentional Childhood Injury;Violence Research;Youth Violence

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE This proposed study has important potential to impact public health and reduce youth firearm-related deaths by scaling out an evidence-based secure firearm storage intervention to pediatric inpatient hospital settings. This cluster randomized clinical trial will test both the effectiveness of an adapted secure firearm storage intervention in improving parent-reported secure storage and secondary firearm safety behaviors, as well as examine the effect of an implementation strategy bundle on intervention reach, acceptability, fidelity, and maintenance. Nurses will lead implementation, highlighting an opportunity for widescale impact by harnessing the expertise of frontline nurses in the work of firearm injury prevention.

PI_NAMEs: HOSKINS, KATELIN  (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Acceleration;Accident and Emergency department;Accidental Injury;African American;Age;Asian;Behavior;Black race;care delivery;Caring;Cause of Death;Cessation of life;Child;Child Health;Child health care;Childhood;Childhood Injury;clinical care;Collaborations;COVID-19 pandemic;Disadvantaged;Discipline of Nursing;Effectiveness;effectiveness testing;effectiveness/implementation trial;Electronic Health Record;Eligibility Determination;Equity;ethnic minority;evidence base;Evidence based intervention;Excision;Exposure to;Family;firearm access;firearm storage;Firearms;Future;Geography;Goals;Gun injury;Harm Reduction;Health behavior;Health system;Healthcare Systems;Homicide;Hospital safety;Hospitalization;Hospitals;Hybrids;implementation outcomes;implementation process;implementation strategy;improved;Inequity;Injury;injury prevention;Inpatients;Insurance;Intervention;intervention mapping;Interview;Lead;Maintenance;Medicaid;Methods;minority children;Modeling;mortality;motivational enhancement therapy;novel;Nurses;Only Child;Outcome;outcome disparities;outpatient programs;Parents;Patient Self-Report;Patients;Pediatric Hospitals;Pediatric Intensive Care Units;Philadelphia;pilot test;population health;Population Heterogeneity;preference;Prevention;Primary Care;primary care clinician;primary outcome;Primary Prevention;Process;programs;Public Health;Quality of Care;Race;racial minority;Randomized;randomized, clinical trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reaction;Reporting;response;Role;Safety;Sampling;secondary outcome;Secure;Services;Site;stem;structural determinants;suburb;suicidal risk;Testing;Translational Research;Translations;treatment as usual;United States;Update;Visit;Well Child Visits;Work;Youth

PROJECT_TITLE: Hybrid Effectiveness-Implementation Trial of a Nurse-Led Firearm Safety Intervention in the Pediatric Inpatient Setting

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Persecutory delusions are extremely common in schizophrenia and cause significant disability and distress. Contemporary mechanistic models suggest that altered belief updating is a cognitive process underlying persecutory delusions, yet rigorous tests of this are needed. We propose to use a clinical trials design to determine whether behavioral and neurobiological aspects of belief updating change with intervention, with the goal of generating knowledge for translation into new treatments.

PI_NAMEs: SHEFFIELD, JULIA MAY (contact)

PROGRAM_OFFICER_NAME: MORRIS, SARAH ELIZABETH

PROJECT_TERMS: active control;adaptive learning;Animal Model;Antipsychotic Agents;arm;Behavior;Behavioral;Belief;biobehavior;Brain;Brain region;clinical application;Clinical Trials Design;Code;Cognitive;cognitive process;Cognitive Therapy;computational neuroscience;Data;Delusions;Development;Diagnostic;disability;Disabling;Distress;Environment;environmental change;expectation;Feeling suicidal;Formulation;Goals;high risk;Hospitalization;improved;indexing;Individual;insight;Intervention;knowledge translation;Learning;locus ceruleus structure;Maintenance;Measurable;Mediating;Modeling;Modification;Nature;neurobiological mechanism;Neurobiology;novel;Outcome;Paranoia;Participant;Patients;Prefrontal Cortex;Probability;Process;psychiatric symptom;Psychiatry;Psychological reinforcement;Psychoses;Psychotherapy;Psychotic Disorders;Randomized;Randomized, Controlled Trials;recruit;Research;Resistance;response;Role;Route;Schizophrenia;schizophrenia spectrum disorder;Severities;Signal Transduction;symptomatic improvement;symptomatology;Symptoms;Testing;therapy development;Thinking;Time;Translating;treatment effect;treatment group;Uncertainty;Update;Volatilization;Work

PROJECT_TITLE: Testing the role of belief updating in persecutory delusions

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Pregnancy;Social Determinants of Health;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Data findings from the parent grant suggest that monocytes and B-cells are differentially expressed in pregnant women chronically exposed to air pollution. This supplement further investigates the mechanism that drives these B-cell and monocyte differences. In addition, Dr Johnson will develop the multi-omics and transcriptomics expertise needed to support and promote her research career, enabling her to compete for future grant funding mechanisms.

PI_NAMEs: NADEAU, KARI C. (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: absorption;Age;Air Pollution;ambient air pollution;Area;Asthma;ATAC-seq;Autoimmune Diseases;Automobile Driving;B-Lymphocyte Subsets;B-Lymphocytes;Birth;Blood;Blood specimen;career;Cell Separation;cell type;Cells;ChIP-seq;Chronic;Clinical;cohort;comparative;Data;Data Analyses;Data Set;differential expression;Disease Outcome;Epigenetic Process;Experimental Designs;Exposure to;Female;Fetus;fine particles;Functional disorder;Funding;Funding Mechanisms;Future;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Grant;Growth;high dimensionality;high risk;histone modification;Histones;Hypersensitivity;IL27RA gene;Immune;Immune system;Immune System Diseases;Immune Tolerance;Individual;Link;Lung;Malignant Neoplasms;Maps;Mass Spectrum Analysis;maternal immune system;Measures;Mediating;Metadata;Methods;Methylation;methylome;Modification;Molecular;monocyte;Mothers;Multiomic Data;multiple omics;National Institute of Environmental Health Sciences;novel;Outcome;parent grant;Parents;Particulate Matter;phenotypic biomarker;Plasma;pollutant;post pregnancy;Pregnancy;Pregnancy Trimesters;pregnant;Pregnant Women;Proliferating;Proteomics;Publishing;Regulatory T-Lymphocyte;Research;response;Role;Sampling;Second Pregnancy Trimester;single cell analysis;single-cell RNA sequencing;Sorting;Stream;T cell receptor repertoire sequencing;T-Cell Receptor;T-Lymphocyte;Testing;Time;tool;toxicant;Toxicant exposure;transcriptome;transcriptome sequencing;transcriptomics;Umbilical Cord Blood

PROJECT_TITLE: Admin Supplement - Immune Tolerance Dysfunction in Pregnancy due to Ambient Air Pollution Exposure


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative von Willebrand factor (vWF) is essential for normal hemostasis and thrombosis and is involved in other important processes such as angiogenesis and cancer cell metastasis. Regulated release of vWF depends on normal maturation of its storage granule, the Weibel-Palade bodies (WPBs), and subsequent fusion of WPBs to the plasma membrane, processes which are poorly understood. Using live cell microscopy, pulldown of endogenously tagged proteins, and a genetically modified mouse model, we propose to elucidate the endosomal pathway in WPB biogenesis, the associated trafficking machinery, and regulation of WPB exocytosis by the exocyst complex.

PI_NAMEs: SHARDA, ANISH VAIBHAV (contact)

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: Adaptor Signaling Protein;Advisory Committees;angiogenesis;Biogenesis;Blood;Blood Cells;Blood Coagulation Disorders;Blood Platelets;Boston;cancer cell;cardiovascular risk factor;Cardiovascular system;career;Cell membrane;Clinical;Coagulation Process;Complex;Cytoplasmic Granules;Dependence;Endosomes;Endothelial Cells;Endothelium;Environment;Exocytosis;Fellowship;fluidity;Gene Modified;Goals;Growth;Hematology;Hemostatic Agents;Hemostatic function;Human;Impairment;innovation;live cell microscopy;Lysosomes;Mediating;Melanosomes;Mentors;Mentorship;Molecular;Molecular Weight;Morbidity - disease rate;mouse model;Neoplasm Metastasis;Organelles;Pathway interactions;Plasma;Play;Process;professor;protein complex;protein transport;Proteins;receptor;Regulation;release factor;Research;Research Personnel;Role;Scientist;Thrombosis;trafficking;Training;Universities;von Willebrand Factor;Weibel-Palade Bodies

PROJECT_TITLE: Molecular Mechanisms Underlying Endothelial Weibel-Palade Body Biogenesis and Exocytosis

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Genetics;Human Genome;Immunotherapy;Microbiome;Nutrition;Prevention;Skin Cancer

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Safe, accessible and effective strategies are urgently needed for cancer patients whose tumors fail to respond to immunotherapy. Given the importance of diet and the gut microbiome in immune response, we will examine how a prebiotic food enriched dietary intervention influences the gut microbiomeand response to immunotherapy in melanoma. Insights gained may have far-reaching implications across immunotherapy treatment for patients with melanoma and other cancers.

PI_NAMEs: DANIEL-MACDOUGALL, CARRIE  (contact);MCQUADE, JENNIFER LEIGH;WARGO, JENNIFER A.

PROGRAM_OFFICER_NAME: EMENAKER, NANCY J

PROJECT_TERMS: Address;Adherence;Animals;anti-CTLA4;anti-PD-1;anti-tumor immune response;Automobile Driving;beta diversity;Biological Markers;Blood specimen;Cancer Patient;cancer type;Caring;Cell Physiology;checkpoint therapy;Clinical;Clinical Research;Clinical Trials;Communities;cost effective;Counseling;CTLA4 gene;Data;Development;Diet;Diet Habits;dietary approach;Dietary Fiber;Dietary Intervention;Donor person;Eating;Ecosystem;effector T cell;fecal transplantation;Fiber;Food;Fortified Food;Future;Gene Expression;Geography;Germ-Free;Glean;Goals;Growth;gut microbes;gut microbiome;gut microbiota;Health;health care disparity;Human;Immune;Immune checkpoint inhibitor;Immune response;immune-related adverse events;Immunotherapy;Impairment;improved;Inflammation;insight;Intake;Intervention;Maintenance;Malignant Neoplasms;Measures;Mediating;Melanoma;Melanoma patient;Metabolite Interaction;metabolome;Metastatic Melanoma;microbial;microbial community;microbiome;microbiota;microbiota composition;microbiota metabolites;Mucous Membrane;Multicenter Trials;Mus;novel;Nutrient;Nutritional;Participant;Pathway interactions;patient subsets;Patients;Phase;post intervention;practice setting;Pre-Clinical Model;prebiotics;preclinical study;predicting response;Progression-Free Survivals;rational design;Refractory;Regimen;response;Safety;Sampling;Specimen;Staging;standard of care;stool sample;success;Survival Rate;Survivors;Testing;Therapeutic;therapeutic target;Toxic effect;Translating;transplant model;Transplantation;tumor;Tumor Immunity;Work

PROJECT_TITLE: Prebiotic diet intervention to enhance the microbiome and immunotherapy response in melanoma

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

PHR: PROJECT NARRATIVE Cells are surrounded by a complex and dynamic polymeric meshwork that connects cells into functional tissues and organs. These polymeric materials provide mechanical and structural cues that direct cellular processes involved in development and tissue maintenance and often become dysregulated in disease, but our understanding of how these physical cues regulate cellular behavior is limited by the lack of suitable engineered systems to study the isolated effects of these important parameters. This project will develop new biomaterials platforms that recapitulate the dynamic and complex mechanical properties of native tissues and then apply these well-controlled platforms to establish causal relationships between physical cues and a broad range of cellular behaviors.

PI_NAMEs: MADL, CHRISTOPHER MATTHEW (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TITLE: Leveraging protein-engineered biomaterials and bioorthogonal chemistries to elucidate the role of non-elastic matrix properties in regulating cell fate

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-F (55)]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Narrative Dopamine plays a critical role in emotion- and motivation-related neural plasticity. While most prior studies examine dopamine receptor-coupled signaling within neuronal cells, led by strong preliminary results, proposed research will test the hypothesis that dopamine D1 receptors on astrocytes mediate cross-synapse signaling transduction that contributes to heterosynaptic plasticity and cue-conditioned nondrug and drug seeking. Outcome of this study may reveal novel cellular targets through which pathophysiological motivation can be manipulated.

PI_NAMEs: DONG, YAN  (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: Amygdaloid structure;Animals;Astrocytes;Behavior;Behavioral;Brain;Brain region;Cell Physiology;Cells;cellular targeting;Clinical;Cocaine;cocaine relapse;conditioning;Coupled;Cues;Dendrites;Dopamine;Dopamine D1 Receptor;Dopamine Receptor;drug of abuse;drug reward;Electrophysiology (science);Emotions;Experimental Designs;experimental study;extracellular;Glutamate Transporter;Glutamates;Hippocampus;Image;innovation;knock-down;Location;Long-Term Potentiation;Mediating;Mission;motivated behavior;Motivation;Mus;Neuronal Plasticity;Neurons;neurotransmission;new therapeutic target;non-drug;novel;Nucleus Accumbens;Outcome Study;Performance;Pharmaceutical Preparations;pharmacologic;Phase;Play;postsynaptic;presynaptic;Presynaptic Terminals;prevent;Process;receptor expression;Receptor Signaling;Relapse;Research;response;Rewards;Role;Signal Transduction;Slice;Substance Use Disorder;Sucrose;Synapses;Synaptic plasticity;Testing;transmission process;United States National Institutes of Health;Viral

PROJECT_TITLE: Cellular and Behavioral Function of Astrocytic Dopamine Signaling

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ORG_CITY: CLEVELAND

ORG_DEPT: GENETICS

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE Improper gene regulation is central to cancer, where transcription factors recruit chromatin machinery to drive disease promoting genes. Focusing on the Androgen Receptor (AR), a transcription factor driving prostate cancer, we will examine the chromatin mechanisms of a new small molecule strategy that swaps the AR from an activator to a suppressor of its target genes, and test this as a therapy for lethal forms of prostate cancer.

PI_NAMEs: GRYDER, BERKLEY E (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: 3-Dimensional;Acetylation;addiction;Adult;advanced prostate cancer;Affect;Agonist;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;androgen sensitive;Androgens;antagonist;Automobile Driving;Binding;Biological Availability;cancer cell;Cell Death;Cell Line;Cell Nucleus;Cells;Chemicals;ChIP-seq;Chromatin;chromatin protein;Chromatin Structure;Clinic;Clinical;clinically relevant;Computational Molecular Biology;Data;deprivation;design;Development;Disease;effectiveness evaluation;Enhancers;enzalutamide;Epigenetic Process;epigenome;experimental study;fluorescence imaging;Gene Cluster;Gene Expression;Gene Expression Regulation;Genes;genetic corepressor;Genetic Transcription;Genome;genome-wide;Goals;Growth;Hepatotoxicity;Homeostasis;In Vitro;in vitro Assay;in vivo Model;KLK3 gene;Learning;Ligand Binding Domain;male;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Measures;men;Metabolic;Modeling;Molecular;Molecular Biology;Mus;Neoplasm Metastasis;novel;novel therapeutics;Nuclear Receptors;Oncogenes;Oral;Organ;overexpression;Pathway interactions;patient derived xenograft model;Patients;Phenotype;Play;preference;programs;promoter;prostate cancer model;Prostate Cancer therapy;Proteins;receptor binding;receptor expression;recruit;Recurrent disease;refractory cancer;Regulation;Relapse;Residual state;Resistance;Role;small molecule;Steroid Receptors;superresolution microscopy;Techniques;Testing;Testosterone;Therapeutic;therapy resistant;Time;Tissues;transcription factor;transcriptome sequencing;tumor;Western Blotting;Work

PROJECT_TITLE: Mechanisms of Androgen Receptor Inverse Agonists in Advanced Prostate Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DMPC-J (90)]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: OVERALL PROJECT NARRATIVE The overarching goal of the Mid-Atlantic Center for Cardiometabolic Health Equity (MACCHE) is to test the effectiveness of comprehensive, integrated, and multi-level evidence-based strategies for improving cardiometabolic health outcomes among socially disadvantaged populations in Maryland, USA. The MACCHE will advance the science of cardiometabolic disease disparities and facilitate its translation into clinical and public health practice and policy.

PI_NAMEs: COOPER, LISA A (contact);CREWS, DEIDRA CANDICE

PROGRAM_OFFICER_NAME: WHITE, DOLLY PENN

PROJECT_TERMS: Address;Adult;Baltimore;Black race;blood pressure control;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;cardiorespiratory fitness;Chronic;Chronic Disease;Chronic Kidney Failure;Clinical;Cluster randomized trial;Collaborations;Communities;community academic partnership;community advisory board;community based participatory research;community engaged research;community engagement;Community Health Aides;community-centered;compare effectiveness;comparison intervention;Complex;data harmonization;Development;Diabetes Mellitus;disease disparity;Disease Management;disorder prevention;Disparity;Disparity population;Economics;effectiveness evaluation;effectiveness testing;Ethnic Origin;evidence base;Fibrosis;fitness;geographic disparity;Goals;Grant;Health;health disparity;health equity;Health equity research;Health Policy;Heart failure;Heart Injuries;High Risk Woman;Home Blood Pressure Monitoring;Home visitation;Hypertension;improved;Infrastructure;innovation;Institution;Intervention;Intervention Studies;Latinx;Leadership;Life Cycle Stages;Link;low socioeconomic status;Maryland;Mentors;Morbidity - disease rate;mortality;multidisciplinary;Myocardial dysfunction;Obesity;Outcome;Outcomes Research;Ownership;Patient Recruitments;patient retention;Patient-Focused Outcomes;Pharmacists;Phase;Pilot Projects;Policies;postpartum health;postpartum weight;Postpartum Women;Pregnancy;Pregnant Women;Problem Solving;programs;Provider;Public Health Practice;Quality of life;Race;randomized trial;Research;Research Personnel;Risk Factors;Science;Services;social disparities;socioeconomic disparity;Structure;team-based care;telemonitoring;Testing;Training;Translating;Translations;treatment as usual;United States;Universities

PROJECT_TITLE: The Mid-Atlantic Center for Cardiometabolic Health Equity (MACCHE)


ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

ORG_STATE: CA

PHR: Southern California consists of 10 contiguous Counties and is home to 10.8 million Latinos (representing 45.2% of the population) who are disproportionally affected by multiple and co-occurring chronic diseases, namely obesity, type 2 diabetes, nonalcoholic fatty liver disease, and dyslipidemia. This disparity begins to develop early in life, occurs within families, is magnified by inter-generational transmission, and is driven by multi-level factors including diet, cultural values, social determinants, economic factors, and environmental-level factors like access to healthy foods and other chemical exposures such as air pollution. Our overall goal is to understand how the complex inter-play between these multi-level factors contribute to multiple chronic disease disparities in Latinos across the life course, and to develop and evaluate the acceptance, delivery, and clinical efficacy of family- based, culturally sensitive solutions by establishing the Southern California Center for Chronic Health Disparities in Latino Families and Children (SCC-CHDLFC).

PI_NAMEs: GORAN, MICHAEL ISAAC (contact)

PROGRAM_OFFICER_NAME: HUELSNITZ, CHLOE OLIVIA

PROJECT_TERMS: Acceleration;Address;Affect;Age;Air Pollution;Biometry;Birth;California;Cardiometabolic Disease;career;Chemical Exposure;Child;Chronic;Chronic Disease;Clinical;clinical efficacy;cohort;Collaborations;Communication;Communities;community engagement;Complex;cost;County;cultural values;Data;Data Analyses;data harmonization;data management;data sharing;design;Development;Diet;disease disparity;disorder risk;Disparity;Dyslipidemias;early-life nutrition;Eating Behavior;Economic Factors;Education;efficacy evaluation;Elderly;Ensure;Environment;environmental intervention;Evaluation;Factor Analysis;Family;Foundations;Funding;Generations;Goals;Government;Health;Health Disparities Research;health disparity;Health Food;Home;Household;Individual;innovation;intergenerational;Intervention;Language;Latino;Latino Population;Lead;Leadership;Life;Life Cycle Stages;literacy;Los Angeles;Mentors;Methods;multidisciplinary;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Obesity;obesity treatment;Outcome;Parents;Pediatric Hospitals;Physical activity;Pilot Projects;Policies;Population;Prevalence;Prevention;Process;programs;randomized, clinical trials;Research;Research Personnel;Resources;response;Risk Reduction;Science;social;social determinants;social factors;success;Support System;synergism;Technical Expertise;telehealth;Testing;transmission process;treatment program;Underrepresented Populations;Universities;voucher

PROJECT_TITLE: Southern California Center for Chronic Health Disparities in Latino Children and Families.


ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: NARRATIVE: The COMMUNITY Center of NYC brings together an interdisciplinary team of investigators, health care providers and community stakeholders around NYC through multi-institutional partnerships (Columbia, Cornell, New York Presbyterian Hospital, Physician Affiliate Group of New York) to reduce health disparities in multiple chronic diseases. We focus on cardiovascular disease and cancer, and their risk factors, as they are the two leading causes of death and that share common social context, etiological pathways, risk factors and management strategies.

PI_NAMEs: COHN, ELIZABETH GROSS;HERSHMAN, DAWN ;PHILLIPS, ERICA ;SHIMBO, DAICHI ;TERRY, MARY BETH  (contact);WILLIAMS, OLAJIDE

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: Address;Adherence;behavioral and social science;biomedical informatics;Biomedical Research;Biometry;Black, Indigenous, People of Color;burden of chronic illness;burden of illness;Cardiometabolic Disease;Cardiovascular Diseases;care delivery;Cause of Death;Cessation of life;Chronic;Chronic Disease;Cities;clinical translation;Collaborations;Colorectal Cancer;Communicable Diseases;Communities;community center;community collaboration;community engagement;Community Health Aides;community organizations;community partners;County;COVID-19;data harmonization;Data Science;design;Development;Dimensions;Disease Outcome;Disparity;disparity reduction;Early Diagnosis;Economics;Enrollment;Environmental Science;epidemiologic data;Epidemiology;Equity;ethnic disparity;Ethnic Origin;Etiology;experience;Faculty;Family;food insecurity;Funding;Geographic Distribution;Goals;Grant;Group Affiliation;Health;health determinants;health disparity;health equity;health equity promotion;Health Personnel;Health Services;health training;Healthcare Systems;high risk;Hospitals;housing instability;implementation science;improved;Individual;Infrastructure;Institution;Insurance;Interdisciplinary Study;Intervention;Learning;Life;Life Expectancy;Malignant Neoplasms;Maps;Medical;Medical center;Methods;Mission;Modeling;mortality;multiple chronic conditions;National Institute on Minority Health and Health Disparities;Neighborhoods;New York;New York City;next generation;novel;Outcome;Participant;Pathway interactions;Personal Satisfaction;Persons;Physicians;Policies;Poverty;Premature Mortality;Presbyterian Church;Prevention;Public Health;Public Policy;Race;Reduce health disparities;Reporting;Research;Research Personnel;Research Project Grants;Risk Factors;Risk Management;Science;segregation;Services;Sleep;sleep health;Social Environment;social health determinants;Societies;Structural Racism;System;Testing;Time;Training;training opportunity;Translational Research;Transportation;Universities;Vision;Voice

PROJECT_TITLE: Center to Improve Chronic disease Outcomes through Multi-level and Multi-generational approaches Unifying Novel Interventions and Training for health EquitY (The COMMUNITY Center)


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE STATEMENT The objective of this research program is to construct voxelated 3D tissues with molecular architecture encoded modular biomaterials to understand and control stem cell function. The resulted knowledge, biomaterials and tools will be broadly useful for creating new in vitro models for investigating biological processes and dysfunction at the cellular and tissue level.

PI_NAMEs: CAI, LIHENG  (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: 3-Dimensional;active lifestyle;Address;Architecture;Area;Behavior;Biocompatible Materials;bioink;Biological;Biological Process;Biomedical Engineering;bioprinting;cell assembly;Cell Communication;cell type;Cells;design;Elasticity;Encapsulated;Engineering;Extracellular Matrix;flexibility;Functional disorder;Gel;in vitro Model;knowledge of results;Location;mechanical properties;Mechanics;Molecular;organizational structure;Physics;Polymer Chemistry;Polymers;Printing;programs;public health relevance;Relaxation;Research;Shapes;stem cell function;stem cell niche;stem cells;Technology;technology platform;Testing;Time;Tissues;tool;Training;Variant;viscoelasticity

PROJECT_TITLE: Constructing 3D voxelated tissues with molecular architecture encoded modular biomaterials to understand and control stem cell function


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Regenerative Medicine;Sarcopenia;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: PROJECT NARRATIVE Alzheimer's disease (AD) is a progressive neurodegenerative brain disease with no effective treatment due to its complicated pathogenesis. We discovered a novel way of treating AD with EVs derived from muscle progenitor cells enriched in neuropeptides responsible for Aβ degradation, and neuroprotection eventually ameliorating AD pathology. This supplement will pave our way towards testing the therapeutic potential of muscle progenitor cells derived EVs against AD.

PI_NAMEs: XUAN, WANLING  (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Acetylcholinesterase;AD transgenic mice;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;American;Amyloid;Amyloid beta-Protein;Amyloid beta-Protein Precursor;amyloid formation;Animals;Apoptotic;Basement membrane;Biodistribution;Biological;Biological Assay;Biological Availability;Blood - brain barrier anatomy;blood-brain barrier crossing;Brain;Brain Diseases;brain dysfunction;Cells;Central Nervous System;Cerebrum;Clinical;cognitive function;Communication;Dementia;Deposition;Development;Disease;disease phenotype;drug development;Drug Kinetics;Economic Burden;effective therapy;efficacy testing;Enzymes;Exercise;extracellular;extracellular vesicles;Foundations;Future;Genes;Genetic Materials;high risk;Hip region structure;Human;human induced pluripotent stem cells;human old age (65+);Impaired cognition;improved;induced pluripotent stem cell;Inflammation;intercellular communication;Intervention;Link;Lipids;Medical;Membrane;Memory Loss;Modeling;mouse model;Mus;Muscle;muscle form;Muscle function;muscle progenitor cell;muscle regeneration;mutant;Neprilysin;Nerve Degeneration;Nerve Regeneration;Neurofibrillary Tangles;neurogenesis;neuroinflammation;Neurons;Neuropeptides;neuroprotection;neurotoxic;novel;novel therapeutic intervention;older adult;Ontology;Organoids;overexpression;parent grant;Parents;Pathogenesis;Pathologic;patient derived induced pluripotent stem cells;Patients;Penetration;Peptides;Peripheral;Pharmaceutical Preparations;Pharmacodynamics;Phenotype;Play;Pre-Clinical Model;preclinical study;prevent;progenitor;progressive neurodegeneration;Proteins;Proteomics;Quality of life;repaired;response;RNA Sequences;Role;sarcopenia;Senile Plaques;Signal Transduction;single-cell RNA sequencing;Site;Skeletal Muscle;symptom management;Synapses;System;targeted treatment;Testing;Therapeutic Effect;therapeutic evaluation;therapeutic target;therapeutically effective;Transgenic Mice;Translating;Vesicle;vesicular release

PROJECT_TITLE: hiPS cells derived skeletal muscle progenitors and their extracellular vesicles for treatment of sarcopenia

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ORG_CITY: MINNEAPOLIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE – Overall The Center for Chronic Disease Reduction and Equity Promotion Across Minnesota (C2DREAM) will reduce disparities in cardiovascular disease (CVD) and the related chronic conditions (RCC) of hypertension and obesity experienced by Black, Indigenous, and people of color (BIPOC) communities including immigrants and refugees across Minnesota. C2DREAM will promote innovative, multilevel interventions that target fundamental causes of chronic disease inequities among BIPOC communities; generate knowledge, analytical and implementation approaches, and community engagement strategies to understand and develop solutions to address racism at multiple levels; develop and support the next generation of health equity researchers; create and sustain a community-engaged and equity-guided dissemination and implementation processes to translate research results and knowledge into action; and employ equity-guided evaluation approaches. Our regional partnership of academic institutions and community stakeholders is poised to understand and ultimately address the ways that racism undermines the well-being of BIPOC communities across Minnesota.

PI_NAMEs: ALLEN, MICHELE L (contact);HARDEMAN, RACHEL R;PATTEN, CHRISTI A

PROJECT_TERMS: Address;Adult;Automobile Driving;Behavioral Medicine;Black, Indigenous, People of Color;Cardiovascular Diseases;career;Chronic;Chronic Disease;Clinic;clinical center;Clinical Sciences;clinical translation;Communication;Communities;community based participatory research;community center;community engaged approach;community engagement;Community Healthcare;Community Networks;County;Development;Diet;disease disparity;Disease Outcome;disorder risk;Disparity;disparity reduction;Dissemination and Implementation;dissemination science;Early Intervention;Effectiveness of Interventions;Epidemiology;Equity;Evaluation;evidence base;experience;Family;Funding;Grant;Hand;Health Disparities Research;health equity;Health equity research;health inequalities;Health Promotion;Health system;Healthcare;Hospitals;Hypertension;Immigrant;implementation process;implementation science;Inequity;innovation;Institution;Intervention;Intervention Studies;Knowledge;Latinx;Leadership;Longevity;Measurement;medical schools;Medicine;Mentorship;Minnesota;minority health;Mission;model design;Modeling;multimodality;Murder;National Center for Advancing Translational Sciences;National Institute on Minority Health and Health Disparities;Native Americans;next generation;Obesity;obesity treatment;outcome disparities;Personal Satisfaction;Physical activity;Police;Policies;Positioning Attribute;prevent;preventive intervention;Primary Care;primary care patient;Process;programs;Psychology;Public Health;Public Health Schools;racism;Refugees;Research;Research Personnel;Research Project Grants;Resources;safety net;smoking cessation;Structural Racism;System;Targeted Research;Techniques;Training;Translating;Translational Research;Translations;Twin Cities;Universities;Work;Youth


PROJECT_TITLE: Center for Chronic Disease Reduction and Equity Promotion Across Minnesota (C2DREAM)


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Cachexia;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Wound Healing and Care

ORG_CITY: LEXINGTON

ORG_DEPT: OTHER CLINICAL SCIENCES

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Severe burn injury triggers profound muscle wasting and weakness which continues long after hospital discharge and results in functional limitations that impair quality of life and contribute to increased morbidity and mortality among burn survivors. The information gained in this program will advance our current understanding of the mechanisms by which burn injury triggers skeletal muscle dysfunction, with a unique focus on fibrogenic and immunologic mechanisms. Elucidating non-canonical cellular and molecular mechanisms of burn-induced muscle dysfunction will unveil therapies to mitigate atrophy and weakness after burn injury, thus improving physical functional recovery in survivors.

PI_NAMEs: OWEN, ALLISON M. (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Agonist;Architecture;Atrophic;Attention;Burn injury;Burn Trauma;Cachexia;Cancer Cachexia;Cell Physiology;cell type;Cells;Collagen;crosslink;Deposition;Epigenetic Process;Extracellular Matrix;Fibroblasts;Fibrosis;Functional disorder;Goals;Hospitals;Immune;Immunologics;immunoregulation;Impairment;improved;Injury;innovation;Intervention;Knock-out;Knowledge;Macrophage;Mechanics;Mediator;Metabolic;Molecular;Morbidity - disease rate;mortality;multiple omics;Mus;Muscle;Muscle Cells;Muscle function;muscle physiology;muscle regeneration;Muscle Weakness;Muscular Atrophy;Myopathy;Natural regeneration;new therapeutic target;Pathologic;Patients;pharmacologic;Phenotype;Positioning Attribute;preservation;Process;programs;Proteomics;Quality of life;Recovery of Function;Research;Role;severe burns;Signal Pathway;Signal Transduction;Skeletal Muscle;Survivors;Techniques;therapeutic target;Tissues;Toll-like receptors;transcriptomics;Transgenic Animals;Transgenic Organisms;wasting

PROJECT_TITLE: Cellular and Molecular Determinants of Post-Burn Myopathy

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


ORG_CITY: COLLEGE STATION

ORG_DEPT: BIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: Project Narrative Type IV pili are important molecular machines and key virulence factors in many clinically important bacterial pathogens. Although the function of TFP is determined by the dynamics of this machine, we know little about the molecular processes that govern TFP dynamics or how TFP machines are assembled molecularly during the cell cycle. Here, we will use a combination of different single-molecule fluorescence microscopy techniques to understand the assembly of TFP machines molecule by molecule, to understand when and where new machines are being built, and how individual motor and effector molecules interact with individual machines, sensory systems, and regulatory systems inside the cell.

PI_NAMEs: KOCH, MATTHIAS DANIEL (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Adhesions;Archaea;Atomic Force Microscopy;Back;Binding;Cell Cycle;Cells;Clinical;Complex;Exhibits;experimental study;Extracellular Space;Fiber;Fluorescence Microscopy;Fluorescence Resonance Energy Transfer;genetic regulatory protein;Individual;insight;Kinetics;light microscopy;Location;Maps;mechanotransduction;Microbial Biofilms;millisecond;Molecular;molecular assembly/self assembly;molecular dynamics;Molecular Machines;Molecular Motors;Motility;Motor;nanomachine;opportunistic pathogen;pathogenic bacteria;Physiological;Pilum;Polymers;Process;programs;Prokaryotic Cells;Proteins;Pseudomonas;Pseudomonas aeruginosa;Research;sensory system;Signal Pathway;single molecule;superresolution microscopy;System;Techniques;Virulence;Virulence Factors;Work

PROJECT_TITLE: Understanding type IV pili on the singe-molecule level

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Dementia;Depression;Mental Health;Neurodegenerative;Neurosciences;Palliative Care;Prevention;Social Determinants of Health

ORG_CITY: DUBLIN

ORG_COUNTRY: IRELAND

ORG_FIPS: EI

ORG_NAME: TRINITY COLLEGE DUBLIN

PHR: PROJECT NARRATIVE Psychosocial resilience in spousal caregivers of spouses with cognitive decline is important in later life for maintaining health and well-being. This study leverages longitudinal data from four large, nationally representative cohorts of older adults with Harmonized Cognitive Assessment Protocol studies to examine associations with psychosocial resilience at an individual-, community- and societal-level. Study results will identify risk and protective factors to inform priorities for social and community-level services.

PI_NAMEs: MCGARRIGLE, CHRISTINE  (contact)

PROGRAM_OFFICER_NAME: TREVINO, MELISSA

PROJECT_TERMS: Address;Adult;Adverse event;aged;Aging;aging in place;Alzheimer's Disease;Alzheimer's disease caregiver;Alzheimer's disease related dementia;care recipients;Caregiver Burden;Caregiver well-being;Caregivers;caregiving;Caring;Clinical;Cognition;Cognitive;cognitive neuroscience;cognitive testing;cohort;Cohort Studies;college;Communities;Complex;Country;Couples;COVID-19 pandemic;Data;Data Analytics;Dementia;depressive symptoms;design;Diagnosis;Disease;Economics;Emotional;Environment;Europe;European;experience;Family;follow-up;Growth;Health;Health and Retirement Study;health data;Health Surveys;Health system;human old age (65+);Impaired cognition;Individual;interest;International;Intervention;Ireland;Knowledge;late life;Life;Longitudinal cohort study;Longitudinal Studies;Measurement;Measures;member;Mental Health;Methods;Modeling;multidisciplinary;multilevel analysis;Nature;older adult;Pattern;Personal Satisfaction;Play;Policies;Population;programs;promote resilience;Prospective, cohort study;protective factors;Protocols documentation;psychosocial;Psychosocial Factor;Psychosocial Influences;Quality of life;Research;Research Personnel;resilience;Retirement;Risk Factors;Role;Sample Size;satisfaction;Services;Shapes;social;social influence;social integration;Social support;Spouse Caregiver;Spouses;Stress;Surveys;Techniques;Testing;Time;Universities;Variant;Withdrawal;Work

PROJECT_TITLE: Risk and protective factors for psychosocial resilience in spousal caregivers for spouses with cognitive decline

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-L (A2)]


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Health disparities in the burden of multiple chronic conditions in the Chicago region are attributed to a history of racial segregation leaving gaps in economic opportunities and gaps in the healthcare system. The Chicago Chronic Condition Equity Network (C3EN) will address these gaps by strengthening and building collaborations across community-based organizations, practice networks, and academic researchers, by promoting a comprehensive approach to the prevention and management of multiple chronic conditions that accounts for mental health, functional health and social life, and by supporting interventions that actively seek to cross boundaries of disease-specific management, professional training, community and practice.

PI_NAMEs: HUANG, ELBERT S. (contact);LYNCH, ELIZABETH B

PROGRAM_OFFICER_NAME: SOLIS SANABRIA, CAROLINA VANESSA

PROJECT_TERMS: Academic Medical Centers;Address;Ambulatory Care;Body System;cardiometabolism;Caring;Charge;Chicago;Chronic;Collaborations;Communication;Communities;community based research;Community Healthcare;community organizations;community setting;County;critical period;Dementia;Diabetes Mellitus;Disease;Disparity;disparity reduction;Economics;Education;Equity;ethnic minority population;evidence base;experience;Federally Qualified Health Center;Foundations;Funding;Geography;Grant;Health;health care service;health care service organization;Health Disparities Research;health disparity;health goals;health professional shortage areas;Health Resources;Healthcare Systems;HIV;Home;implementation science;improved;Individual;individual patient;Informatics;innovation;Institution;inter-institutional;Interdisciplinary Study;interest;Intervention;Knowledge;Life;Low income;Malignant Neoplasms;medical specialties;Mental Health;Mentors;Modeling;multiple chronic conditions;Neighborhoods;Network-based;opioid use;Outcome;Persons;Pilot Projects;Poverty;prevent;Prevention approach;Preventive;Primary Health Care;psychologic;Public Health;Quality of Care;racial minority population;Racial Segregation;Recording of previous events;remote sensor;Research;Research Personnel;Research Project Grants;Research Support;Resources;safety net;Science;sensor technology;Services;social;Social Functioning;social health determinants;software systems;System;Time;Training;Training Programs;translational medicine;Translational Research;United States National Institutes of Health;Universities


NIH_SPENDING_CATS: Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: INDIANAPOLIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE We will develop technology that enables the rapid discovery of new bicyclic peptides—molecules with diagnostic and therapeutic applications against a range of diseases. We will apply this technology towards the discovery of bicyclic peptides with broad-spectrum antiviral properties against coronaviruses that cause severe respiratory disease in humans.

PI_NAMEs: THARP, JEFFERY MICHEAL (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Acceleration;Adopted;Affinity;Amino Acids;Amino Acyl-tRNA Synthetases;Anti-viral Agents;Antibodies;Binding;Chemicals;combinatorial;Consumption;Coronavirus;Cyclic Peptides;Cyclization;Cysteine;Development;Diagnostic;Directed Molecular Evolution;Disease;Engineering;Evolution;functional group;Genetic Code;Human;human coronavirus;inhibitor;Laboratories;Libraries;Ligands;Membrane Fusion;Methods;Modeling;Molecular Conformation;novel;Peptide Conformation;peptide drug;Peptide Library;Peptides;Phage Display;Property;Proteins;Proteolysis;Reaction;Resistance;Respiratory Disease;Ribosomes;Route;scaffold;small molecule;System;Techniques;Technology;Therapeutic;Time;Viral;Viral Physiology;Virus;Work

PROJECT_TITLE: Genetically encoded bicyclic peptide libraries for the discovery of novel antiviral agents

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


PROJECT_TITLE: Chicago Chronic Condition Equity Network (C3EN)


ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: NARRATIVE – OVERALL The Center for Research, Health, and Social Justice (CRHS) will use a social justice framework to conduct research, engage communities, and build a diverse and competent research workforce to reduce disparities in cancer and cardiovascular disease. Social justice focuses on improving lives and wellbeing of historically marginalized and oppressed groups that face racism and discrimination. The CRHS is designed to become a national model for eliminating chronic disease disparities using social justice informed research, training, and community engagement.

PI_NAMEs: CORNELL, CAROL ELLEN (contact);FAGAN, PEBBLES ;GUY, MIGNONNE CATHERINE

PROGRAM_OFFICER_NAME: JOSEPH, SUSAN KALAPURA

PROJECT_TERMS: Address;African American;African American population;Arkansas;Black Populations;Black race;cancer health disparity;Cardiovascular Diseases;Chronic Disease;Clinical and Translational Science Awards;Collaborations;Communities;community academic partnership;community engagement;community intervention;community partners;community partnership;County;Death Rate;design;Development;Disadvantaged;Discrimination;disease disparity;disorder risk;Disparity;disparity elimination;disparity reduction;Distress;economic indicator;Ecosystem;Employment Opportunities;Equity;Ethnic Population;evidence base;experience;Extramural Activities;Face;food insecurity;Foundations;Funding;Generations;Goals;Grant;Health;health care availability;Health Disparities Research;health disparity;health inequalities;Heart Diseases;improved;Infrastructure;innovation;Institution;interdisciplinary collaboration;Intervention;Knowledge;Left;lens;Life Cycle Stages;Life Expectancy;Link;Malignant Neoplasms;marginalization;Measures;member;Mentors;Methods;Modeling;Monitor;mortality;National Institute on Minority Health and Health Disparities;novel;Outcome;Pattern;Personal Satisfaction;Pilot Projects;Policies;Postdoctoral Fellow;Poverty;Process;programs;Race;racial disparity;racial population;racism;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Risk Factors;Rural;rural area;rural dwellers;Science;skills;Social Justice;social structure;socioeconomics;Standardization;structural determinants;Structure;success;Surveys;System;tool;Training;Training and Infrastructure;training opportunity;Translating;Translational Research;Trauma;Trust;Underrepresented Populations;United States;United States National Institutes of Health;urban area;Wages;Work


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Cancer;Clinical Research;Interstitial Cystitis;Prevention;Prostate Cancer;Radiation Oncology;Urologic Diseases

ORG_CITY: ROCHESTER

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: NARRATIVE Acute and chronic bladder toxicities can occur in patients treated with pelvic radiotherapy, often causing severe and progressively debilitating sequalae. The proposed project investigates the mechanisms of tissue injury in the irradiated bladder and a urine-based injury biomarker to evaluate well-tolerated FDA-approved modifiers of the renin angiotensin pathway that we have shown can prevent these radiotherapy side-effects, using preclinical models and human biosamples. In terms of long-term goals, this study aims to prevent radiotherapy toxicities by offering an inexpensive and safe therapy for cancer patients most susceptible to developing bladder injury.

PI_NAMEs: KERNS, SARAH L.;MARPLES, BRIAN  (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Activities of Daily Living;Acute;Affect;Angiotensin Receptor;Angiotensin-Converting Enzyme Inhibitors;Angiotensinogen;Angiotensins;Antiinflammatory Effect;Binding;Biological;Biological Factors;Biological Markers;biomarker identification;Bladder;Bladder Dysfunction;Bladder Injury;Blood Vessels;Cancer Patient;cancer radiation therapy;cancer therapy;care costs;CCL2 gene;Cells;Cellular Stress;chemokine;Chronic;Clinical;Clinical Research;Clinical Treatment;cohort;comorbidity;Complication;cost;Cytokine Signaling;Data;Development;Dose;Dysuria;early detection biomarkers;effective therapy;Emergency department visit;Etiology;extracellular vesicles;Failure;FDA approved;Fibrosis;Fractionated radiotherapy;Functional disorder;Gene Expression;Generations;genome wide association study;Goals;Hematuria;Homeostasis;Human;Hyperbaric Oxygen;Hyperbaric Oxygenation;Hypertension;Immune;Impairment;improved;Incidence;Incontinence;Increased frequency of micturition;Inflammation;Inflammatory;inhibitor therapy;Injury;Intervention;Kinetics;Link;Lisinopril;Longitudinal cohort study;Macrophage;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Mediating;men;micturition urgency;Modality;Modeling;monocyte;mouse model;Multi-site clinical study;Mus;Muscle;nanoparticle;Normal tissue morphology;novel marker;novel therapeutics;Pathology;Pathway interactions;Patient Compliance;Patients;Pelvis;Peptidyl-Dipeptidase A;Pharmaceutical Preparations;pharmacologic;phase I trial;pre-clinical;Pre-Clinical Model;predicting response;predictive marker;Predisposition;preservation;prevent;Prevention;Preventive therapy;Procedures;prostate cancer model;prostate cancer survivors;Prostate Cancer therapy;prostate radiotherapy;Proteins;Proteomics;radiation cystitis;Radiation Protection;Radiation therapy;Radiation Toxicity;radioprotected;receptor;Recording of previous events;recruit;reduce symptoms;Renin;Renin-Angiotensin System;Reporting;response;Role;Schedule;screening;Serum;Severities;side effect;Signal Transduction;Symptoms;Testing;Therapeutic;tissue injury;Tissues;Toxic effect;transcriptome sequencing;Transgenic Mice;translational approach;Treatment-related toxicity;tumor;urinary;Urination;Urine;urologic;urothelial injury

PROJECT_TITLE: Targeting angiotensin and inflammation to prevent radiotherapy-induced bladder toxicity.

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Diabetes;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE This research examines the influence of pancreas dynamics during pregnancy on the development of diabetes. MRI measurements of pancreas size, shape, and composition will be made over time in both the mother and the fetus to see how the pancreas is affected by maternal diabetes. Pancreas phenotypes will be correlated with metabolic phenotypes as assessed by glucose tolerance testing and continuous glucose monitoring.

PI_NAMEs: VIROSTKO, JOHN MICHAEL (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: Abdomen;Affect;Beta Cell;Biological Assay;Birth;Cell Physiology;Cell Proliferation;cellular imaging;Child;Continuous Glucose Monitor;Data;Data Set;Development;Diabetes Mellitus;diabetes risk;diabetogenic;Diagnosis;Disease;Disease remission;Energy Metabolism;Exhibits;Fatty acid glycerol esters;fetal;Fetal Development;Fetus;Functional disorder;Gene Expression;Gestational Diabetes;glucose metabolism;Glucose tolerance test;Growth;high risk;High Risk Woman;Hormonal;Hormones;Human;Image;improved;in utero;Incidence;Individual;Infiltration;Inflammation;Insulin Resistance;insulin secretion;lifetime risk;Link;Liver;Magnetic Resonance Imaging;maternal diabetes;Measurement;Measures;Metabolic;metabolic phenotype;Metabolism;Methods;Modeling;Monitor;Mothers;Multimodal Imaging;multimodality;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;Nuclear;Obesity;offspring;Organ;Pancreas;pancreas imaging;Participant;Pathogenesis;Phenotype;Physiological;Placenta;Play;Postpartum Period;Prediabetes syndrome;Pregnancy;Process;Proliferating;Research;Risk;Role;secondary analysis;Shapes;Structure;Structure of beta Cell of islet;Testing;Time;type I and type II diabetes;Weight Gain;Woman;Women's cohort;Work

PROJECT_TITLE: Diabetes Prediction During Pregnancy and In Utero Using Pancreas MRI

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE The mission of the Deep South Center to Reduce Disparities in Chronic Diseases is to promote health equity and reduce the burden of cardiometabolic diseases, including obesity, diabetes, and hypertension, among Black Americans and low-income populations in our tri-state region (i.e., Alabama, Mississippi, Louisiana). The Center represents a partnership between the University of Alabama at Birmingham, Tuskegee University, Pennington Biomedical Research Center, and the University of Mississippi Medical Center, along with regional non-academic partners to translate and sustain cardiometabolic research in real-world community and clinical settings. The Center is focused on expanding and diversifying the region’s research workforce, promoting equitable collaborations between researchers and non-academic partners, and advancing scientific discovery through synergistic research projects focused on multi-level, multi-domain interventions for the prevention, treatment, and management of cardiometabolic diseases in the Deep South.

PI_NAMEs: BASKIN, MONICA L.;CHERRINGTON, ANDREA L (contact);DUTTON, GARETH R

PROGRAM_OFFICER_NAME: OLADEINDE, YEWANDE A

PROJECT_TERMS: Address;Alabama;Area;base;Belief;Biomedical Research;Black American;Cardiometabolic Disease;cardiometabolism;Chronic Disease;Clinical;clinical care;clinical center;Clinical Sciences;Collaborations;Communities;community engagement;community setting;comorbidity;Continuity of Patient Care;COVID-19 pandemic;Deep South;Development;Diabetes Mellitus;Disease;Disparity;disparity elimination;disparity reduction;effective intervention;Equity;ethnic minority;Evidence based intervention;experience;Foundations;Geographic Locations;Geography;Goals;Gossypium;Health Disparities Research;health disparity;health equity;health equity promotion;Health equity research;Heart;Hypertension;improved;Individual;Inequality;Infrastructure;innovation;Institution;Intervention;Knowledge;Leadership;Life Expectancy;Link;Louisiana;Low income;Low Income Population;Medical center;meetings;member;Mission;Mississippi;National Institute on Minority Health and Health Disparities;nutrition;Obesity;Outcome;Phase;Policies;Population;preference;Prevention;programs;Public Health;Race;racial minority;Reduce health disparities;Research;Research Personnel;Research Project Grants;Resources;Risk;Rural Community;Scientific Advances and Accomplishments;socioeconomics;synergism;Time;Translating;Translational Research;Translations;Universities


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: The burden of chronic disease disparities is most evident among African American and Hispanic/Latino populations in the southeastern United States. To address these pervasive health inequities, the Southeast Collaborative for Innovative and Equitable Solutions to Chronic Disease Disparities we will bring together expertise at Vanderbilt University Medical Center, University of Miami School of Medicine, and Meharry Medical College to collaboratively develop and implement multi-level interventions. The Center will partner with communities and will leverage advances in technology and data science to reduce risk factors for and disparities in diabetes, cardiovascular disease, obesity, and related conditions among African American and Latino populations.

PI_NAMEs: COX, NANCY J;MILLER-HUGHES, STEPHANIA T.;WEISS, ROY E;WILKINS, CONSUELO HOPKINS (contact)

PROJECT_TERMS: Academic Medical Centers;adaptive intervention;Address;African American;African American population;Asthma;Award;Behavior;Behavioral;Bioinformatics;Biological;Black Populations;Black race;burden of chronic illness;Cardiovascular Diseases;career development;Cause of Death;Cessation of life;Chronic;Chronic Disease;Clinical;Collaborations;Communities;community engaged intervention;Community Health Aides;Complex;coping mechanism;culturally appropriate intervention;Data;data harmonization;Data Science;Decision Making;Dentists;design;diabetes management;Diabetes Mellitus;Disadvantaged minority;Discipline;Discrimination;disease disparity;Disparity;Doctor of Philosophy;Environment;Equity;ethnic health disparity;ethnic minority;experience;Faculty;family support;Fostering;Genetic;genomic data;Glycosylated hemoglobin A;Health;health data;Health Disparities Research;health disparity;health equity;Health Expenditures;health inequalities;Health Insurance;Health Professional;Health Services Accessibility;Health system;Hispanic;Home;Human;Hypertension;implementation science;improved;Individual;Infrastructure;innovation;Institution;International;Intervention;Latino;Latino Population;Lead;Link;Lived experience;Malignant Neoplasms;medical schools;Medicine;Mentors;mHealth;Minority;novel;Obesity;Operative Surgical Procedures;Outcome;Patients;Personal Satisfaction;personalized medicine;phenotypic data;Physicians;Policies;Population;population health;Poverty;premature;prevent;preventable death;Prevention;professional atmosphere;professor;programs;Psyche structure;Quality of life;racial health disparity;racial minority;racism;Research;Research Personnel;Resources;Risk;Risk Factors;Risk Reduction;Rural Community;Science;Scientist;Secure;Services;skills;Sleep;social;social health determinants;Social support;Social Work;Socioeconomic Status;Southeastern United States;Stephania;Structural Racism;Structure;Technology;Testing;Time;Tobacco use;Training;Trauma;United States Public Health Service;Universities;Urban Community;Vascular Diseases


ORG_CITY: DETROIT

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: NARRATIVE Compelling evidence indicates that the key to increasing lifespan equality is saving lives at ages below ~70 years. The ACHIEVE GREATER Center is designed to do just that by ameliorating cardiometabolic health disparities during early phases of pathogenesis in order to improve Black-White lifespan inequality in two uniquely comparable, densely populated, and severely affected cities: Detroit, MI, and Cleveland, OH.

PI_NAMEs: LEVY, PHILLIP DAVID (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: Address;Affect;Age;Archives;Area;Biological Specimen Banks;black patient;Black Populations;Black race;blood pressure elevation;built environment;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;career;Cause of Death;Censuses;Characteristics;Chronic;Cities;Clinical;cloud based;cohort;Collaborations;collaborative care;Communities;community engagement;Community Health Aides;Community Outreach;comorbidity;Coronary heart disease;cost effective;Data;Data Collection;data management;data warehouse;Databases;density;design;Development;disease disparity;Disparity;Diverse Workforce;Electronic Health Record;Ensure;Environment;epidemiology study;evidence base;Evidence based intervention;extend lifespan;Fostering;Future;Geographic Locations;Goals;Grant;health disparity;health inequalities;Health Services Accessibility;Health system;Heart;Heart Diseases;Heart failure;high risk population;Home;Hypertension;implementation intervention;improved;Incidence;Inequality;informatics tool;Infrastructure;Ingestion;Institution;Interruption;Intervention;Life;life span;Life Style;Location;Mentors;Methods;Michigan;Mobile Health Units;National Institute on Minority Health and Health Disparities;Ohio;outreach;Participant;Pathogenesis;Pathway interactions;Persons;Pharmacists;Phase;Pilot Projects;Policy Maker;Poverty Areas;Practical Robust Implementation and Sustainability Model;Prevention;programs;Public Health;Race;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Reduce health disparities;remediation;Research;Research Design;Research Personnel;Resources;Risk;Risk Factors;Scientist;skills;Social Behavior;social health determinants;social vulnerability;Statistical Data Interpretation;System;Training;Universities;University Hospitals;virtual;Vision;Work

PROJECT_TITLE: ACHIEVE GreatER: Addressing Cardiometabolic Health Inequities by Early PreVEntion in the Great LakEs Region


ORG_CITY: HADLEY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

ORG_STATE: MA

PHR: Narrative This project will focus on understanding the fundamental mechanisms of tissues closing millimeter-size gaps, which is important for embryo development, regeneration, and wound healing. The proposed work will develop new tools to measure physical parameters and identify key biomolecules that are involved in such processes for various tissue types under different environmental stimuli.

PI_NAMEs: SUN, YUBING  (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Actins;Adhesions;Bioinformatics;Biological Models;Biomedical Engineering;Biophysics;Cells;Cellular biology;Collaborations;Cytoskeleton;Data;design;Devices;DNA;Embryonic Development;Environmental Risk Factor;Epithelial Cells;epithelial to mesenchymal transition;Epithelium;Extracellular Matrix;fluidity;Fluorescence;Frequencies;Generations;Geometry;Goals;graduate student;Growth;Homeostasis;Intercalated Cell;journal article;kinematics;Maintenance;Measures;mechanical properties;mechanical signal;Mechanics;Mediating;Medical Device;Mesenchymal;migration;millimeter;Molecular;Molecular Biology;Molecular Biology Techniques;Neurosciences;novel;Pattern;Play;Postdoctoral Fellow;Process;Productivity;Proliferating;Property;Publishing;regenerative healing;Research;Research Personnel;Role;sensor;single-cell RNA sequencing;spatiotemporal;Stimulus;Tissues;tool;TP53 gene;Traction Force Microscopy;transcriptomics;undergraduate student;Work;wound healing

PROJECT_TITLE: Biophysics and Cell Biology of Meso-scale Gap Closure

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Cardiovascular disease accounts for 1 in every 3 deaths in the US, many of which are caused by ischemic heart disease and acute myocardial infarction, which can lead to heart failure, for which there is no cure. Our proposed studies aim to decipher the molecular mechanisms contributing to ischemic heart disease. We anticipate that in the future this knowledge will help to develop new, mechanistically specific and selective treatments for heart disease and, thus, reduce mortality.

PI_NAMEs: GLEMBOTSKI, CHRIS  (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: Acute myocardial infarction;Affect;Antioxidants;ATF6 gene;Binding;biological adaptation to stress;Biological Assay;Biotin;Cardiac;Cardiac Myocytes;cardioprotection;Cardiovascular Diseases;Catalytic Domain;Cell Line;Cell model;Cessation of life;Complex;Cytosol;Development;Endoplasmic Reticulum;endoplasmic reticulum stress;Equilibrium;Future;Genes;Genome;Heart;Heart Diseases;Heart failure;heart function;Heat shock proteins;In Vitro;in vivo;Infarction;innovation;Ischemia;Kinetics;knock-down;Knowledge;Label;Life Cycle Stages;Link;Mass Spectrum Analysis;Measures;Mediating;Membrane;Methods;misfolded protein;Modeling;Molecular;mortality;mouse model;multicatalytic endopeptidase complex;Mus;Mutate;Myocardial;Myocardial Ischemia;novel therapeutics;overexpression;Pathology;Process;programs;Protein Biosynthesis;protein degradation;protein function;protein misfolding;Protein Secretion;Proteins;Proteome;Proteomics;proteostasis;receptor;Reperfusion Injury;Reperfusion Therapy;Research;Ribosomes;Role;Ros protein;selenoprotein;sensor;SERCA2a;small hairpin RNA;Stable Isotope Labeling;Stress;Structure;Time;Toxic effect;transcription factor;transcriptome sequencing;ubiquitin-protein ligase

PROJECT_TITLE: Roles for endoplasmic reticulum associated degradation (ERAD) in Myocardial Proteostasis

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome

ORG_CITY: BOSTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE When a genetic variant causes increased risk of developing a disease, it can provide valuable insight into disease biology. However, a major challenge is often to understand the functional effect of disease-causing variants. This application proposes the development of computational methods to link disease association data with diverse functional datasets, in order to understand the relationship between the functional effect of a variant and its effect on the risk of disease.

PI_NAMEs: O'CONNOR, LUKE JEN (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: 3-Dimensional;Alleles;Architecture;Area;Artificial Intelligence;Binding Proteins;Biological;Biology;Code;Complement;Computing Methodologies;Data;Data Set;Development;Disease;disease-causing mutation;disorder risk;Dissection;exome;Genes;Genetic;genetic architecture;genetic association;Genetic Code;genetic variant;Genetic Variation;Genome Scan;genome wide association study;Heterogeneity;Individual;insight;interest;Learning;Link;Measurement;Methods;Modeling;Mutation;Pathogenicity;Phenotype;Productivity;Property;protein structure prediction;Protein Truncation;Proteins;Publishing;rare variant;Risk;RNA Splicing;Series;Site;Source;Statistical Methods;Testing;trait;Translating;Untranslated Regions;Variant

PROJECT_TITLE: The functional and phenotypic effects of protein coding genetic variation


ADMINISTERING_IC: OD

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Gene Therapy;Genetics;Human Genome;Neurodegenerative;Rural Health

ORG_CITY: COLUMBIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative The use of genetically engineered (GE) pigs is critical for advancing both biomedical and agricultural applications but are underutilized, in part, due to the safety and efficacy of the technology, as well as, the time required to establish and propagate these models. Developing strategies that assist in preserving genome integrity and for rapid identification of phenotypes will allow for the rapid expansion of GE pig models. Increasing the availability of GE pig models will have clear impacts on preclinical models for gene therapy and quickly identifying pigs with improved agricultural traits.

PI_NAMEs: LEE, KIHO  (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: Agriculture;Alleles;Anatomy;Animal Model;Animals;Area;Biochemical;Biological;Biological Assay;Biology;Breeding;Clinic;Clinical;clinical effect;clinical outcome assessment;clinical phenotype;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Cystic Fibrosis;Data;design;Detection;detection platform;Disease;disease phenotype;Early Diagnosis;efficacy evaluation;Embryo Cloning;Event;Exclusion;Family suidae;fetal;Fetus;Food production;gene function;gene therapy;Genes;Genetic;Genetic Diseases;genetic element;Genetic Engineering;Genome;genome editing;genome integrity;genome sequencing;Genomics;Goals;Heritability;Human;human disease;Immune;Immune response;immunodeficiency;improved;in vivo;inhibitor;Investments;Knowledge;Length;Life Cycle Stages;Link;Livestock;Methods;Modeling;Modification;Molecular;Monitor;novel;novel strategies;Outcome;Patients;Phenotype;Physiology;pig genome;porcine model;Porcine respiratory and reproductive syndrome virus;postnatal;Pre-Clinical Model;predictive tools;Pregnancy;preservation;Procedures;Process;Production;Puberty;Research;Research Activity;Resistance;Resources;response;Safety;Secure;side effect;single-cell RNA sequencing;Site-Directed Mutagenesis;small molecule;Somatic Cell;Symptoms;System;Technology;Testing;therapy outcome;Time;tool;trait;United States Department of Agriculture;United States National Institutes of Health;Variant;whole genome

PROJECT_TITLE: Enhancing The Value of Pigs for Agriculture and Biomedical Applications By Using Novel Genome Editing Strategies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(56)-R]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Low-income pregnant and postpartum people (PPP) enrolled in Medicaid experience suboptimal and inequitable quality of care and pregnancy-related outcomes, especially PPP from racial/ethnic minorized groups. Federally qualified health centers (FQHCs) could play a key role in improving maternal health outcomes and equity at scale by addressing drivers of maternal health care inequities, as FQHCs may improve access, care integration and coordination, and address unmet social needs, yet very limited evidence is available to guide policymakers, health systems, managed care plans, or FQHCs. This research will therefore fill this critical evidence gap by evaluating if and how FQHCs, and direct provision of maternity care at FQHCs, can improve quality and equity of care for PPP by leveraging a novel natural experiment using national claims data and qualitative interview data.

PI_NAMEs: COLE, MEGAN B. (contact)

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: Accident and Emergency department;Address;Affect;Age;Back;Birth;black patient;Black race;care coordination;care seeking;care systems;Caring;clinical risk;Contracts;County;Coupled;cultural competence;Data;Data Sources;design;Enrollment;Entropy;Equilibrium;Equity;ethnic identity;ethnic minority population;Ethnic Origin;Event;experience;Failure;Federally Qualified Health Center;follow-up;Geographic Locations;Goals;Health;health care disparity;health plan;Health Services Accessibility;Health system;Heterogeneity;Improve Access;improved;improved outcome;Income;Inequity;Information Systems;Interview;Leadership;Link;Literature;Location;Low income;Managed Care;Managed Care Programs;Maternal Health;Maternal Health Services;Measures;Medicaid;medical specialties;Methods;Minor;Modeling;Natural experiment;novel;Outcome;Outpatients;Patients;people of color;perinatal outcomes;perinatal period;Persons;Play;Policies;Policy Maker;postpartum care;Postpartum Period;Pregnancy;Pregnancy Outcome;pregnant;Premature Birth;prenatal;Prenatal care;Primary Care;primary care setting;primary health center;Private Practice;Provider;Proxy;Quality of Care;Quasi-experiment;Race;racial difference;racial minority population;Research;Role;screening;Services;severe maternal morbidity;Shapes;Site;social;Social Work;Structure;success;System;underserved area;Visit

PROJECT_TITLE: Assessing the role of Federally Qualified Health Centers in advancing quality and equity of care for pregnant and postpartum Medicaid enrollees

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-D (90)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

ORG_CITY: PITTSBURGH

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: NARRATIVE – OVERALL COMPONENT The Core Grant for Vision Research supports the work of a diverse group of vision scientists in the Pittsburgh area conducting research on vision, infectious disease, causes of blindness, and developing new therapies to prevent blindness. The grant provides critical support to NEI-funded investigators, and it supports pilot studies that can be incorporated into new NIH/NEI R01 applications from new investigators or established investigators moving into vision research. The services and equipment provided by this grant allow our vision scientists to integrate diverse scientific approaches into their vision research projects and thereby enhance their overall impact.

PI_NAMEs: ASH, JOHN D (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Area;Award;base;Biomechanics;Blindness;cell regeneration;Cellular biology;Cities;Clinical;Collaborations;Communicable Diseases;Communities;Core Facility;Core Grant;Cornea;Creativeness;data submission;Dedications;Development;Environment;Equipment;experience;Faculty;Faculty Recruitment;Floor;Fostering;Foundations;Funding;Glaucoma;Goals;graduate student;Grant;Growth;Home;Hour;Human Resources;Image;Immunology;innovation;International;Knowledge;Laboratories;Methodology;Names;Natural regeneration;novel therapeutics;ocular microbiome;operation;Ophthalmology;Pilot Projects;Play;Postdoctoral Fellow;pre-doctoral;prevent;Productivity;programs;Prosthesis;Qualifying;recruit;Request for Proposals;Research;research faculty;Research Methodology;Research Personnel;Research Project Grants;Research Support;Research Training;Resources;Retina;Role;Scientist;Services;stem cell biology;stem cell therapy;student training;Students;success;Technology;Trabecular meshwork structure;Training;Training Programs;undergraduate student;United States National Institutes of Health;Universities;Vision;Vision research;vision science;Visual;visual neuroscience;Work

PROJECT_TITLE: Core Grant for Vision Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (07)]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

PROJECT_TITLE: Administration Module


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD)

PI_NAMEs: SIGAL, IAN A (contact)

PROJECT_TERMS: Applications Grants;Cell Culture Techniques;Cells;Complex;Computer software;Computer Workstations;Computers;confocal imaging;Consultations;Core Grant;Custom;Darkness;Data;data acquisition;Data Analyses;Data Collection;data integrity;design;Development;Digital Photography;Dissection;Environment;Equipment;Ethics;Experimental Designs;Faculty;faculty support;Fluorescence;Four-dimensional;Freezing;Funding;Histologic;Histology;Image;Image Analysis;image processing;Immunohistochemistry;Implant;Knowledge;Label;Laboratories;laser capture microdissection;Lasers;light microscopy;live cell imaging;live cell microscopy;member;Methods;Microscope;Microscopic;microscopic imaging;Microscopy;Modality;Modernization;monolayer;Paraffin Embedding;Phase;Plastic Embedding;polarized light;Preparation;programs;Protocols documentation;Publications;quantitative imaging;reconstruction;Research;Research Personnel;Resources;sample fixation;Sampling;Scanning;Scientist;screening;Secure;Services;Stains;success;Technical Expertise;Techniques;Tissue Embedding;tissue preparation;tissue processing;Tissue Sample;Tissues;Training;Training Support;Vision;Vision research;Visualization

PROJECT_TITLE: Histology, Imaging, and Analysis Module


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurosciences

PI_NAMEs: ROSSI, ETHAN A (contact)

PROJECT_TERMS: Acceleration;Animals;Biological Assay;Brain;Calibration;clinically relevant;Collaborations;Collection;Computer software;Conceptions;Core Grant;Custom;Data;Dedications;design;Development;Devices;Diagnostic;Electronics;Engineering;Ensure;Equipment;experience;Eye;fabrication;Faculty;faculty research;Floor;Funding;Funding Opportunities;fundus imaging;Future;Goals;Image;Imaging Device;Imaging technology;in vivo;in vivo evaluation;in vivo Model;Individual;innovation;instrumentation;Investigation;KRAS2 gene;Laboratories;Lead;Location;manufacture;Measurement;Measures;Mechanics;microelectronics;Modernization;Names;Nature;Neurosciences;new technology;next generation;optical imaging;Optics;Pathway interactions;Phase;Procedures;Process;Production;prototype;Research;Research Personnel;Resources;Retina;retinal imaging;Rodent;Schools;Services;Specialist;Speed;Structure;success;Testing;Time;Tissues;tool;Training;Translating;Translational Research;United States National Institutes of Health;Universities;Update;Vision;Vision research;Visual;visual processing;Visual System;Work

PROJECT_TITLE: In Vivo Testing and Instrumentation Module