NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Rare Diseases

ORG_CITY: SAN ANTONIO

ORG_NAME: TEXAS BIOMEDICAL RESEARCH INSTITUTE

PHR: NARRATIVE  Many genera of viruses are comprised of different species, each continually evolving new exterior protein landscapes that can make broad spectrum countermeasure development very challenging. We have developed novel nanobodies that target interior proteins which are less prone to evolution and enable uniform binding of all species of the genus Ebolavirus. Our goal is to explore the antiviral potential of these nanobodies in in vitro tissue culture systems to determine if they can inhibit a broad spectrum of ebolaviruses that have emerged over the past 45 years.

PI_NAMEs: HAYHURST, ANDREW  (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Affinity;Antibodies;Antibody Therapy;Antigen Targeting;Area;Avidity;Binding;Capsid;Cells;Compensation;Coronavirus;coronavirus pandemic;crosslink;Crosslinker;design;Detection;Development;Diagnostic;dimer;Disease;DNA;Ebola virus;Engineering;Ensure;env Gene Products;Epitopes;Escape Mutant;Escherichia coli;Evolution;Exhibits;expression vector;Family;Felis catus;Foundations;Future;Generations;Genes;Glycosaminoglycans;Goals;Health;Human;human disease;Immune system;In Vitro;Individual;Infection;Influenza vaccination;interest;Intervention;Intrabody;Mammalian Cell;Mediating;member;Modeling;Monitor;monomer;Mus;mutant;Mutation;nanobodies;Nature;neutralizing antibody;nonhuman primate;novel;novel coronavirus;novel strategies;Nucleoproteins;Parents;particle;pathogenic virus;Penetration;Peptides;Pharmaceutical Preparations;Plasmids;Polymers;Predisposition;preference;Process;protein oligomer;Proteins;Reagent;Research;Resources;Risk;RNA vaccine;RNA Viruses;Seasons;Site;Small Interfering RNA;Specificity;stoichiometry;Structural Protein;success;Surface;System;Technology;Testing;Therapeutic antibodies;Time;tissue culture;Transfection;variants of concern;Viral;Viral Genome;Viral Hemorrhagic Fevers;Viral Physiology;Viral Proteins;Viral Structural Proteins;Virion;Virus;Virus Assembly;Virus Cultivation;Virus Replication;Virus-like particle;Work

PROJECT_TITLE: Novel antiviral strategy offering forward capability and reduced risk of escape

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-S(02)]


ADMINISTERING_IC: HD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Gene Therapy;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Rett Syndrome;Women's Health Research

ORG_CITY: MAYWOOD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

ORG_STATE: IL

PHR: NARRATIVE  Monogenic neurodevelopmental disorders like Rett syndrome appear to be ideal candidates for gene therapy; however, targeting the causative gene (methyl-CpG binding protein 2, MeCP2) itself with traditional gene replacement strategies is complicated by a stringent requirement for protein dosage. Here we propose that the administration of locked nucleic acid (LNA)-modified antisense oligonucleotides (ASOs) designed to outcompete endogenous repressive-miRNA for regulation of the MeCP2 3’untranslated region is a viable therapeutic approach for RTT patients with missense or late-truncating mutations. Our preliminary support this theory, as mir-22, mir-132, and mir-483 site-blocking ASOs increase MeCP2 expression in a dose-dependent manner which is capped at subtoxic levels by the relatively modest contribution of each endogenous miRNA to MeCP2 regulation.

PI_NAMEs: GOGLIOTTI, ROCCO GEORGE (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: 3' Untranslated Regions;Adverse effects;Alleles;Antisense Oligonucleotides;autism spectrum disorder;Binding;Binding Sites;Brain;Candidate Disease Gene;Cell Line;Cells;Cementation;Chemicals;Chemistry;clinical development;Data;derepression;design;Development;Disease;dosage;Dose;effective therapy;experience;Fibroblasts;Foundations;Gene Expression;gene replacement;gene therapy;Genes;Goals;Human;improved;In Vitro;in vivo;Individual;Induced pluripotent stem cell derived neurons;Kinetics;locked nucleic acid;loss of function;loss of function mutation;MeCP2 Duplication Syndrome;Messenger RNA;Methyl-CpG-Binding Protein 2;MicroRNAs;Modification;Morphology;mouse model;mRNA Expression;Mus;mutant;Mutation;Nature;neuroblastoma cell;Neurodevelopmental Disorder;Neurosciences;oligonucleotide delivery;Osmosis;Outcome Measure;overexpression;Pathology;patient subsets;Patients;Phenotype;posttranscriptional;preservation;prevent;protein expression;Proteins;Pump;Reader;Regulation;Reproducibility;Research;response;restoration;Rett Syndrome;RNA Splicing;RNA-Binding Proteins;Role;Safety;safety assessment;Seminal;Series;Site;Spinal Muscular Atrophy;Sugar Phosphates;Surface;Symptoms;Synapses;Syndrome;targeted treatment;Testing;theories;Therapeutic;tool;Transgenic Organisms;treatment strategy;Vertebral column;Viral;Viral Genes;virulence gene

PROJECT_TITLE: miRNA site-blocking ASOs as MeCP2 targeted therapeutics

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome

ORG_CITY: HERSHEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE Over the past three decades, the incidence of early onset colorectal cancer (EOCRC) has been steadily increasing. Genetic analysis of patient-derived colonic tissues and tumors indicate that deregulation of the Wnt/ß- catenin signaling pathway may contribute to colorectal carcinogenesis in this patient population. Work in this proposal will define critical downstream targets of aberrant Wnt/ß-catenin signaling and identify novel pathway interactors that drive EOCRC. This research is needed to support targeting this pathway, or genes whose expression it regulates, to improve patient care.

PI_NAMEs: YOCHUM, GREGORY S. (contact)

PROGRAM_OFFICER_NAME: CERO, CHERYL

PROJECT_TERMS: Address;Adherence;APC gene;APC mutation;Attention;Automobile Driving;beta catenin;biobank;Biochemical;Biological Assay;Biological Models;Cancer Etiology;Caring;Cells;Cessation of life;Chromatin;Colon;colon cancer patients;colon carcinogenesis;colon growth;Colonic Neoplasms;Colonoscopy;Colorectal;Colorectal Cancer;Colorectal Neoplasms;CRISPR/Cas technology;Data;Data Set;design;Development;Diagnosis;Diagnostic;differential expression;Disease;early onset colorectal cancer;early-onset colorectal carcinogenesis;effective therapy;Environmental Risk Factor;Epigenetic Process;Familial Adenomatous Polyposis Syndrome;fusion gene;Future;Gene Expression;Gene Expression Profile;Gene Targeting;Genes;Genetic;genetic analysis;genetic regulatory protein;Genetic Research;Genetic Screening;genetic signature;Genetic Transcription;genome-wide;Genomics;Goals;Green Fluorescent Proteins;Growth;Growth Factor;Human;improved;Incidence;Individual;Knock-out;Knowledge;Lead;lentivirally transduced;Lentivirus;Malignant Neoplasms;Modality;Mutation;novel;novel marker;novel therapeutics;Nuclear;Oncogenic;Operative Surgical Procedures;Organoids;Outcome;Pathogenesis;Pathway interactions;Patient Care;patient population;Patients;Pattern;Population;programs;Proteins;Recommendation;Research;Research Personnel;Resected;Role;Sampling;screening;sedentary lifestyle;Seminal;Signal Pathway;Signal Transduction;small hairpin RNA;Talents;Testing;Therapeutic Intervention;Tissue-Specific Gene Expression;Tissues;Transcription Coactivator;transcriptome sequencing;tumor;Tumor Suppressor Proteins;Uncertainty;Unhealthy Diet;Western Blotting;western diet;Work

PROJECT_TITLE: Wnt/beta-catenin signaling in early-onset colorectal cancer


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Genetics;Neurosciences;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: PHOENIX

ORG_NAME: ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Contusion expansion is a common and devastating secondary injury after traumatic brain injury, causing death, extensive long-term disability, and a significant health-economic burden to society; yet there is no cure. Current guideline-based care is reactive and non-specific- it neither prevents nor limits contusion expansion and struggles to mitigate the life threatening consequences. This study focuses on key actionable pathways and will identify biomarkers and precise therapeutic targets to predict and prevent contusion expansion, thus directly advancing the NINDS mission to reduce the burden of neurological disease.

PI_NAMEs: JHA, RUCHIRA MENKA (contact);KOHANBASH, GARY

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Acute;Address;Affect;Atlases;biobank;bioinformatics pipeline;Biological Markers;biomarker identification;Brain;Caring;Cause of Death;cell type;Cells;Cerebrospinal Fluid;Cerebrospinal Fluid Proteins;Clinical;Clinical Trials;Complex;computational pipelines;Contusions;Custom;Data;Detection;Development;differential expression;Disease;disease heterogeneity;druggable target;Economic Burden;first-in-human;Foundations;Frequencies;Future;Genes;Genetic;genetic signature;genetic variant;Glyburide;Goals;Guidelines;health economics;Heterogeneity;high risk;Human;Image;Immune response;improved outcome;Individual;Individual Differences;Injury;innovation;Knowledge;Life;Link;Long term disability;Measurable;mild traumatic brain injury;Mission;Molecular;Molecular Profiling;Monitor;Morbidity - disease rate;mortality;multidisciplinary;Mus;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurosciences;new therapeutic target;novel;Outcome;Participant;Pathway interactions;Patient Selection;patient stratification;Patients;Pharmaceutical Preparations;Pharmacodynamics;Phase;Phenotype;pre-clinical;precision medicine;prevent;Prevention strategy;Preventive;Process;Prospective cohort;protein biomarkers;Proteins;Proteomics;Research;response;response biomarker;Risk;risk stratification;Sampling;Selection for Treatments;Signal Pathway;single-cell RNA sequencing;Societies;Source;standard care;sulfonylurea receptor;targeted treatment;TBI treatment;Testing;therapeutic target;Tissue-Specific Gene Expression;transcriptome;transcriptomics;Translating;Translations;Traumatic Brain Injury;trial design;Work;X-Ray Computed Tomography

PROJECT_TITLE: A Single Cell and Proteomic Precision Medicine Approach to Glyburide Responsive Contusion Expansion in Severe Traumatic Brain Injury

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: LA JOLLA

ORG_NAME: LA JOLLA INSTITUTE FOR IMMUNOLOGY

ORG_STATE: CA

PHR: NARRATIVE Progress in the use of epitopes for cancer immunology and immunotherapy is hampered by a disconnect in information technology, which segregates investigators from the data and tools needed to appropriately conduct their research. Development of a Cancer Epitope Database and Analysis Resource will overcome this issue by harmonizing and centralizing the capture of cancer epitope data, and by using these data to establish and evaluate epitope analysis and prediction tools that will be made freely available to the research community.

PI_NAMEs: PETERS, BJOERN ;SETTE, ALESSANDRO  (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Address;Adopted;Adoptive Transfer;Animal Model;anti-cancer research;Antibodies;Attention;Autoimmunity;B-Cell Antigen Receptor;B-Lymphocytes;Benchmarking;Binding;Bioinformatics;Biological;Cancer Biology;Cancer Histology;cancer immunotherapy;Catalogs;Clinical;clinical phenotype;Clinical Research;Collection;Communicable Diseases;Communities;Complement;Contracts;cost effective;Data;Data Set;database structure;Databases;design;Development;Disease Outcome;disease phenotype;Engineering;Epitopes;Evaluation;Exclusion;experience;Feedback;functional improvement;Funding;Goals;Human;Hypersensitivity;Immune;immune checkpoint blockade;immunogenicity;Immunologics;Immunology;Immunotherapy;Individual;Informatics;Information Technology;Infrastructure;interest;interoperability;Intuition;Journals;Link;Literature;Machine Learning;Malignant Neoplasms;meetings;Methodology;Modification;Mutation;National Institute of Allergy and Infectious Disease;Nature;neoantigens;novel;Ontology;Outcome;outreach;outreach program;Performance;personalized medicine;predictive tools;Procedures;Process;programs;Property;prospective;prototype;Publications;Publishing;receptor;Recurrence;Reporting;Research;Research Personnel;Resources;Role;Sampling;segregation;single cell sequencing;Specificity;Study models;success;T-Cell Immunologic Specificity;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Epitopes;Technology;Therapeutic;tool;translational cancer research;Transplantation;treatment strategy;tumor;Tumor Antigens;tumor immunology;Tumor Tissue;Tumor-Infiltrating Lymphocytes;United States National Institutes of Health;Vaccination;Vaccines;Validation;web site;web-accessible

PROJECT_TITLE: THE CANCER EPITOPE DATABASE AND ANALYSIS RESOURCE


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Infectious Diseases;Vector-Borne Diseases

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

ORG_STATE: NY

PHR: PROJECT NARRATIVE This project will adapt methods from our current SEPA project to establish DNA barcoding for use in informal settings. Our objective is to equip visitors to science centers and nature preserves and members of community conservation groups to inventory species in local habitats. These citizen scientists will contribute new information to global biodiversity databases and improve range maps that show how species are responding to environmental change.

PI_NAMEs: MICKLOS, DAVID ANDREW (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Ants;arboviral disease;Attitude;Bar Codes;Biochemical;Biodiversity;Bioinformatics;citizen science;climate change;Collaborations;college;Communities;County;Culicidae;Data;Data Analyses;Databases;design;Development;Disease Vectors;DNA;DNA Databases;Education;Education and Outreach;Educational Materials;environmental change;Equipment;Equipment and supply inventories;Evaluation;experience;Faculty;Genbank;Global Warming;Goals;Habitats;Health;high school;High School Student;human disease;improved;Infrastructure;Insecta;interest;Laboratories;Learning;Long Island;Maps;member;Mentorship;Methods;Modeling;Monitor;Museums;Nature;New York;novel;Order Coleoptera;Organism;outreach;outreach program;Participant;Phase;preservation;Program Evaluation;programs;Publishing;Research;Resources;Sampling;Science;science education;science museum;Scientist;Site;Societies;Structure;success;Surveys;symposium;System;Taxonomy;Teacher Professional Development;Techniques;Training;vector;web interface;Work

PROJECT_TITLE: Citizen DNA Barcode Network:  A Community-based Infrastructure for Monitoring Biodiversity and Disease Vectors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Lung;Pulmonary Hypertension;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative  Schistosomiasis-induced pulmonary hypertension (Sch-PH) is a major cause of pulmonary arterial hypertension worldwide, a group of incurable illness marked by progressive narrowing of the blood vessels in the lungs and eventual death due to right heart failure. Despite the high prevalence of the disease, the limited understanding of how Sch-PH develops precludes the establishment of effective treatment. This proposal aims to examine the potential role of glucose metabolism in generating the pathologic changes of Sch-PH, with the ultimate goal of identifying metabolism-modulating therapeutic strategies.

PI_NAMEs: LEE, MICHAEL HYUNJEAN (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Address;arterial lesion;Biological Assay;Blood Vessels;Carbon;career development;Cell Proliferation;Cell Separation;Cessation of life;Citric Acid Cycle;Classification;Coculture Techniques;Confocal Microscopy;Data;Data Analytics;design;Development;Development Plans;Disease;effective therapy;Enzymes;experimental study;Fermentation;fibrogenesis;Flow Cytometry;Genes;Genetic Transcription;Genus Hippocampus;Glucose;glucose metabolism;glucose uptake;Glycolysis;Glycolysis Induction;Goals;Grant;Growth;High Prevalence;Human;hypoxia inducible factor 1;hypoxia-induced pulmonary hypertension;In Situ;Infiltration;inhibitor;insight;interstitial;Knowledge;Label;lactate dehydrogenase A;Lesion;Link;Lung;Macrophage;Mass Spectrum Analysis;Medial;Mentors;Mentorship;Metabolic;Metabolism;Mitochondria;Mus;Myeloid Cells;neglected tropical diseases;novel;Oral;Pathogenesis;Pathologic;Pentosephosphate Pathway;Phenocopy;Phenotype;Positioning Attribute;Production;Proliferating;protective effect;protein expression;Proteomics;pulmonary arterial hypertension;Pulmonary arterial remodeling;Pulmonary artery structure;Pulmonary Hypertension;pulmonary vascular remodeling;Research Personnel;Resistance;Resources;right ventricular failure;Role;Schistosomiasis;Scientist;Severities;skills;Smooth Muscle Myocytes;spatiotemporal;Structure of parenchyma of lung;Tamoxifen;Testing;Therapeutic;Thick;Time;Training;transcription factor;Transgenic Mice;Translational Research;Up-Regulation;uptake;Vascular Proliferation

PROJECT_TITLE: The contribution of hypoxia inducible factor-1-dependent glycolysis in lung interstitial macrophages to the pathobiology of schistosomiasis-induced pulmonary hypertension.

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Estrogen;Menopause;Neurodegenerative;Neurosciences;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Narrative Alzheimer’s disease (AD) is one of the most important public health challenges of our time, with women disproportionately impacted. We will uniquely examine whether mitochondrial function plays a critical role in understanding sex differences in memory circuitry function and the early emergence of AD-related pathology. This study will advance our knowledge on the long-term implications for the co-occurrence of brain and metabolic disorders, and the sex differences therein, and highlight potential mechanistic targets for therapeutic strategies.

PI_NAMEs: KONISHI, KYOKO  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: 8-hydroxy-2'-deoxyguanosine;Affect;Age;aged;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-42;Anterior;Area;Bioenergetics;Biological Markers;Biometry;Blood specimen;blood-based biomarker;Brain;Brain Diseases;Brain imaging;Cardiometabolic Disease;career;Cell Respiration;Cells;Cerebrum;Chronology;cingulate cortex;clinical diagnosis;cohort;Data;Data Analyses;Data Collection;Disproportionately impacts women;Estradiol;Family Study;follow-up;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;Genetic;Glucose;glucose metabolism;Goals;Gonadal Steroid Hormones;Grant;Health;Hippocampus;imaging modality;in vivo;Individual;Inferior;Insulin;Knowledge;knowledge base;Life Expectancy;Light;Link;Lipids;Measures;Mediating;Mediator;Medical;Memory;Memory Loss;men;Menopausal Status;Menopause;Mentored Research Scientist Development Award;Metabolic;Metabolic Diseases;Metabolic dysfunction;middle age;Mitochondria;mitochondrial dysfunction;neurofilament;New England;novel;offspring;Organelles;Oxidative Stress;Parietal Lobe;Pathology;Pathway interactions;Performance;Perimenopause;Peripheral Blood Mononuclear Cell;Persons;Physiological;Play;Positioning Attribute;Postmenopause;precision medicine;Prefrontal Cortex;Premenopause;prenatal;Process;Production;prospective;Public Health;Reproductive History;reproductive senescence;Research;Research Personnel;Respiration;Risk Factors;Role;sex;Sex Differences;Site;skills;Source;Structure;targeted treatment;tau Proteins;Testing;Time;Training;Translational Research;United States National Institutes of Health;white matter;Woman;Work;Writing

PROJECT_TITLE: Sex Differences in Alzheimer's disease-Related Pathology: Role of Mitochondrial Function and Metabolic Health

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Project Narrative ROADmAP incorporates evidence- and theory-based cognitive-behavioral change strategies, including features from the Diabetes Prevention Program, to decrease overweight/obesity rates among taxi/for-hire vehicle (FHV) drivers. It is innovative in 3 key respects: 1) It is the first study to utilize the Multiphase Optimization Strategy to develop an optimized, scalable lifestyle intervention specifically adapted for drivers, including in a virtual environment; 2) It will be implemented in community-embedded settings to address barriers to access experienced by underserved low socioeconomic status, mulitlingual driver communities, reaching drivers who may not otherwise be reached by the traditional health care system; 3) It is the first to use implementation science to facilitate more rapid translation of an effective lifestyle intervention to a multilingual format, in the taxi/FHV driver environment, with tremendous dissemination potential for gig economy essential workers. If successful, ROADmAP can potentially lead to broad implementation among large and growing taxi/FHV and other driver populations (e.g. bus, truck drivers) throughout the US.

PI_NAMEs: GANY, FRANCESCA M (contact);LENG, JENNIFER CF

PROGRAM_OFFICER_NAME: HERREN, OLGA MARINA

PROJECT_TERMS: Address;Adoption;Affect;Attitude;Behavior;behavior change;Behavioral;Belief;Blood Pressure;Body mass index;Body Weight decreased;cancer health disparity;cancer risk;Cardiovascular Diseases;cardiovascular disorder risk;care outcomes;Cholesterol;Cognitive;Communities;community organizations;community setting;Consolidated Framework for Implementation Research;Consumption;cost;cost estimate;Counseling;Data;design;Development;diabetes prevention program;Diet;effectiveness study;effectiveness/implementation hybrid;Environment;Essential worker;Expectancy;experience;Health;Health Benefit;health care availability;health care service;health disparity;Health Fairs;health inequalities;Healthcare Systems;hybrid type 1 design;Hybrids;Immigrant;implementation intervention;implementation science;implementation strategy;implementation study;improved;incremental cost-effectiveness;Individual;innovation;Intake;Intervention;intervention delivery;Interview;Knowledge;Lead;Licensing;lifestyle intervention;Link;Literature;low socioeconomic status;Mediation;Mediator;Methods;Minority;Minority Groups;Monitor;Multilingualism;multiphase optimization strategy;New York City;Not Hispanic or Latino;nutrition;Obesity;obesity risk;obesity treatment;Occupational;Outcome;Outcome Study;Overweight;Participant;Persons;Physical activity;physical inactivity;Population;primary outcome;process evaluation;programs;Randomized;recruit;Resources;Risk;secondary outcome;sedentary lifestyle;Self Efficacy;social cognitive theory;Surveys;Telephone;Testing;Text Messaging;theories;tool;Translations;treatment optimization;Unhealthy Diet;uptake;virtual;virtual environment;waist circumference;Weight;weight loss intervention;weight loss program;Work;Workplace

PROJECT_TITLE: Taxi ROADmAP (Realizing Optimization Around Diet And Physical activity)

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

PHR: Project Narrative:  RAS proteins (KRAS, NRAS, and HRAS) are the most extensively studied set of mutationally activated oncogenes. Yet we do not completely understand the structural impact of RAS mutations in cancer. In this proposal, I will create and analyze a unified RAS structural classification and nomenclature to compare the impact of oncogenic mutations on KRAS, HRAS, and NRAS.

PI_NAMEs: PARKER, MITCHELL ISAAC (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: 3-Dimensional;Agreement;Alanine;Antibodies;Behavior;Binding;Biochemical;Biological;Canada;cancer therapy;Classification;cohort;Complex;computational suite;Computer software;computerized tools;conformer;Databases;design;electron density;Europe;Event;experimental group;experimental study;Future;Genes;GTP Binding;Guanosine Triphosphate;Homodimerization;Human;improved;inhibitor;insight;KRAS2 gene;Ligand Binding;Ligands;Malignant Neoplasms;Missense Mutation;Molecular Conformation;molecular dynamics;Mutate;Mutation;Mutation Analysis;mutational status;Nomenclature;novel;Oncogenes;Oncogenic;Output;Patients;Pattern;Pharmaceutical Preparations;Phosphotransferases;preference;protein data bank;protein protein interaction;protein structure;Proteins;RAS genes;ras Proteins;Resources;Roentgen Rays;Scanning;Signal Pathway;Site;Statistical Data Interpretation;Structure;SWI1;Testing;tumor;United States;Update;Visualization;web server;Work

PROJECT_TITLE: Creating a Unified RAS Structural Nomenclature to Compare the Impact of Oncogenic Mutations on KRAS, NRAS, and HRAS


NIH_SPENDING_CATS: Aging;Atherosclerosis;Behavioral and Social Science;Cardiovascular;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Prevention;Social Determinants of Health

ORG_NAME: BOSTON MEDICAL CENTER

PHR: Project Narrative: Doctors use prediction models to help them prevent heart attacks and stroke in healthy adults. However, these models do not apply to everyone, including transgender and cisgender adults using hormone therapy. This project aims to provide new methods of predicting and preventing heart attacks and strokes in these unique groups of people.

PI_NAMEs: STREED, CARL G (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Accounting;Address;Adult;Affect;Algorithms;Area;Atherosclerosis;Attitude;Birth;Boston;Cardiology;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cessation of life;cis-female;cis-male;cisgender;Classification;clinical decision-making;Clinical Skills;Code;cohort;Collaborations;community engagement;comorbidity;Consolidated Framework for Implementation Research;Data;Data Analyses;Data Collection;data warehouse;Development;Diabetes Mellitus;Diagnosis;Discrimination;disease model;Disease Outcome;Electronic Health Record;Endocrinology;Equation;Exogenous Hormone Therapy;experience;Faculty Workshop;Federally Qualified Health Center;Female;follow-up;Future;Gender;gender affirming care;Gender Identity;gender minority;Goals;Grant;Health;hormone therapy;Hormone use;Hormones;Hyperlipidemia;Hypertension;implementation science;improved;indexing;Individual;Intervention;Intramuscular;K-Series Research Career Programs;Knowledge;male;meetings;Mentored Research Scientist Development Award;Mentors;Mentorship;Methods;Modeling;Morbidity - disease rate;mortality;multidisciplinary;Myocardial Infarction;National Heart, Lung, and Blood Institute;novel;Oral;Outcome;Patients;Persons;Play;Population;predictive modeling;prevent;Preventive care;Primary Prevention;Procedures;programs;Qualitative Research;Recommendation;Records;recruit;Research;Research Personnel;Resources;Review Literature;Risk;Risk Assessment;Risk Factors;Risk Management;risk mitigation;risk prediction model;Role;Route;Scientist;Sensitivity and Specificity;Services;sex;sex assigned;Sexual and Gender Minorities;Site;skills;Statistical Models;statistics;Stroke;success;Surveys;symposium;Tobacco;Tobacco use;Training;transgender;transgender men;transgender women;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Building methods to assess and address cardiovascular health in transgender adults

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Genetics;HIV/AIDS;Human Genome

ORG_CITY: KUALA LUMPUR

ORG_COUNTRY: MALAYSIA

ORG_FIPS: MY

ORG_NAME: UNIVERSITY OF MALAYA

PHR: PROJECT NARRATIVE To meet the need for increasing research ethics capacity in Malaysia and Southeast Asia, in partnership with collaborators from the Berman Institute of Bioethics at Johns Hopkins University, this initiative aims to enhance the leading-edge Master of Health Research Ethics (MOHRE) program at Universiti Malaya (UM). Program enhancements will include increasing program flexibility to increase enrolment of working individuals positioned to make meaningful contributions to research ethics, strengthening the program by using a newly articulated competency framework, and implementing a robust UM faculty development program. By the end of the project period, the MOHRE program will be more sustainable and be positioned to help meet local and regional needs in research ethics.

PI_NAMEs: HANAFI, NIK SHERINA  (contact);KAMARULZAMAN, ADEEBA ;SUGARMAN, JEREMY

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Accreditation;Advocacy;Articulation;Award;Bioethics;Collaborations;Communication;Competence;COVID-19 pandemic;Degree program;design;E-learning;Education;Educational Curriculum;Educational process of instructing;Educational Status;Educational workshop;Enrollment;Ensure;Ethical Issues;Ethics;Ethnic Origin;experience;Faculty;faculty mentor;flexibility;Fogarty International Center;Funding;Future;Goals;Guidelines;Health;Hour;improved;Individual;interest;International;Knowledge;Laws;Leadership;life-long learning;low and middle-income countries;Malaysia;Malaysian;Measures;member;Mentors;novel;Outcome;Persons;Policies;Policy Research;Positioning Attribute;Problem-Based Learning;professional students;Program Development;Program Evaluation;programs;recruit;Regulation;Religion;Research;Research Activity;Research Ethics;Resolution;Resource Sharing;Resources;response;Schedule;Scholarship;Series;skills;skills training;sound;southeast Asian;Southeastern Asia;Structure;Student Selections;Students;System;Teacher Professional Development;Time;Time Study;Trainers Training;Training;Training Programs;Trust;Universities;Vocational Guidance;Work

PROJECT_TITLE: Strengthening the Master of Health Research Ethics Training Program


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Radiation Oncology;Women's Health Research

ORG_DEPT: PATHOLOGY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Triple negative breast cancer cells have higher therapeutic resistance and poor treatment response. This research project will study mechanism of microRNA alteration in cancer cells for inducing key protein upregulation to increase tumor growth and therapeutic resistance. The new findings will elucidate new mechanism of therapeutic resistance and identify new target(s) for improving cancer treatment option in the future.

PI_NAMEs: HE, JUN  (contact)

PROGRAM_OFFICER_NAME: PEREZ, J MANUEL

PROJECT_TERMS: Affect;Alternative Splicing;Amino Acids;angiogenesis;Animal Model;Biology;Breast Cancer Cell;Breast Cancer Patient;Breast Cancer Treatment;cancer cell;cancer survival;cancer therapy;Cell Line;Cell model;Cells;chemotherapy;Chemotherapy and/or radiation;cohort;Data;Development;DNA;DNA Methylation;Doxorubicin;Endothelial Cells;Estrogen receptor positive;experimental study;Family;Future;Goals;Heterogeneous-Nuclear Ribonucleoproteins;HNRPA3 gene;Homologous Gene;Human;Hypermethylation;IL8 gene;improved;knock-down;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;member;Metabolic;Methylation;MicroRNAs;Modeling;Molecular;mortality;multidisciplinary;Muscle;new therapeutic target;orthotopic breast cancer;overexpression;paracrine;Pathway interactions;patient derived xenograft model;Play;Polypyrimidine Tract-Binding Protein;Promoter Regions;Protein Isoforms;Protein Kinase;Proteins;Pyruvate Kinase;Radiation;Radiation therapy;receptor;Research Project Grants;Resistance;Role;Signal Pathway;solute;Testing;Therapeutic;Therapeutic procedure;therapy resistant;Tissues;translational potential;treatment response;triple-negative invasive breast carcinoma;tumor;Tumor Angiogenesis;tumor growth;tumor metabolism;Tumor Tissue;Up-Regulation;Warburg Effect;Woman

PROJECT_TITLE: MiR-152/PKM2/SLC7A5 axis in breast cancer development, chemo- and radiation-treatment response

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE This study identifies the impact of adverse community-level policing (CLP) exposure on Alzheimer’s disease related dementia (ADRD) racial disparities. This proposal leverages data collected from the Health and Retirement Study to explore the correlations between life course adverse CLP exposure with incident dementia, cognitive decline, accelerated aging, and poor psychological health in Black and Latinx/a/o older adults. Results from this study may illuminate a modifiable political factor that could be targeted for intervention to reduce disproportionate incidence of ADRD in historically marginalized communities.

PI_NAMEs: ADKINS-JACKSON, PARIS  (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Accountability;Active Learning;Adult;Affect;age acceleration;Aging;Alzheimer's disease related dementia;Area;Award;biological adaptation to stress;Biological Aging;Black Populations;Black race;burden of illness;Cardiovascular system;career;career development;Cities;cognitive function;Communities;Complement;County;Crime;Data;Dementia;dementia risk;depressive symptoms;deprivation;Development Plans;Dimensions;Disadvantaged;Disparity;Drug usage;Environment;epigenetic clock;experience;Exposure to;Frequencies;Fright;Funding;Goals;Health;Health and Retirement Study;health data;Health Disparities Research;health disparity;healthy aging;Homeostasis;Immigration;Impaired cognition;Imprisonment;Incidence;Inflammation;Injury;intergenerational;Intervention;Justice;killings;Knowledge;late life;Latina;Latino;Latino Population;Latinx;Law Enforcement;Leadership;Life;Life Cycle Stages;life history;Link;Literature;longitudinal analysis;marginalized community;marginalized population;Measures;Medical center;Memory;Mental Health;Mental Health Services;Mentored Research Scientist Development Award;Mentors;middle age;Names;National Institute on Aging;Neighborhoods;Nerve Degeneration;Not Hispanic or Latino;older adult;Outcome;Paris, France;Participant;Pathway interactions;Perception;Performance;Police;Police officer;Political Factor;Population;post-traumatic stress;programs;psychologic;Public Health Schools;racial disparity;racism;Research;Research Personnel;residential segregation;Risk;Role;Schools;Science;segregation;Seminal;social;statistics;Stress;structural determinants;structural health determinants;Structural Racism;System;Taxes;Training;Trauma;United States;Universities;violent crime;Well in self;Work;Writing

PROJECT_TITLE: The role of adverse community-level policing exposure on disparities in Alzheimer's  disease related dementias and deleterious multidimensional aging


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE During cell division, called mitosis, a critical step for maintaining healthy living cells is segregation of the replicated chromosomes to two daughter cells, which is mediated by a dynamic structure called the mitotic spindle. We do not fully understand how the spindle forms, or how it adjusts its size and shape in different cell types. Investigating this process is important, since errors in spindle function can lead to cancer and other human diseases.

PI_NAMEs: HEALD, REBECCA W (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Address;Affect;Architecture;Area;Automobile Driving;Biochemical;Biological;Biological Assay;Biology;Biophysical Process;Cell division;Cell Nucleus;Cell Physiology;Cell Size;cell type;Cells;Centromere;Chromosome Condensation;chromosome missegregation;chromosome replication;Chromosome Segregation;Chromosomes;Ciona intestinalis;Collaborations;Computer Models;Cytoplasm;Cytoskeleton;daughter cell;Defect;Development;DNA;egg;Embryo;embryo cell;Embryonic Development;Ensure;Event;Evolution;Gene Expression;Genome;Genomics;human disease;Hybrids;in vivo;innovation;insight;Interphase;Kinetochores;Laboratories;laser tweezer;Life;Link;Malignant Neoplasms;Measures;Mediating;Meiosis;Microfluidics;Microscopy;Microtubules;Mitosis;Mitotic;Mitotic Chromosome;Mitotic spindle;Molecular;Morphology;novel;novel strategies;Oocytes;optic tweezer;Organelles;Organism;Phylogenetic Analysis;Physiology;Ploidies;Process;Productivity;Proteomics;Rana;reproductive;Research;Resolution;Role;segregation;sensor;Shapes;single molecule;sperm cell;Structure;Surface;System;Techniques;Testing;Time;Urochordata;virtual;Xenopus;xenopus development

PROJECT_TITLE: Mechanisms of mitosis and size control in Xenopus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Lung squamous carcinomas (LUSC) are a leading cause of cancer-related deaths in the U.S., however they are highly idiosyncratic and rarely driven by solitary actionable pathways. We have uncovered a previously unappreciated CDR1as/CDR1 axis that regulates LUSC metastasis and is highly associated with patient survival. This proposal seeks to uncover the fundamental mechanisms responsible for how CDR1 regulates LUSC metastasis through Golgi function, vesicular trafficking and metastasis, and to evaluate the biologic and therapeutic implications of targeting the CDR1as structure.

PI_NAMEs: PECOT, CHAD V (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Accounting;Alternative Splicing;anti-cancer research;Antisense Oligonucleotides;Architecture;Bioinformatics;Biological;Cancer Etiology;Cancer Patient;Cerebellar degeneration;Cerebellar Degeneration Related 1 Antisense;Cessation of life;Chemicals;chemotherapy;Clinical;Coat Protein Complex I;Code;Complex;Couples;Cues;Cytoskeleton;Data;Dependence;Electron Microscopy;Elements;Epithelium;experimental study;genetic approach;Genetic Epistasis;Genetic Transcription;Golgi Apparatus;human disease;Immunohistochemistry;improved;insight;Interruption;Knock-out;Ligands;Light;Lung Adenocarcinoma;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Mediating;Mesenchymal;Messenger RNA;Methods;Microscopy;migration;Modeling;Molecular Profiling;mouse model;Mutate;Neoplasm Metastasis;Non-Small-Cell Lung Carcinoma;novel therapeutics;Nucleotides;Oligonucleotides;Outcome;overexpression;Pathway interactions;Patients;Phenotype;Play;Primary Neoplasm;programs;protein transport;Proteins;Regulation;Resolution;RNA;RNA Stability;Role;Sampling;Site;spatial relationship;Squamous Cell Lung Carcinoma;stem;Structure;Survival Rate;Systemic Therapy;targeted treatment;The Cancer Genome Atlas;Therapeutic;trafficking;tumor;tumorigenic;Untranslated RNA;Vesicle;vesicle transport

PROJECT_TITLE: Circle RNA Regulation of Lung Cancer Metastasis

STUDY_SECTION: TEHM

STUDY_SECTION_NAME: Tumor Evolution, Heterogeneity and Metastasis Study Section[TEHM]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Microbiome;Pediatric;Prevention

ORG_CITY: CAMBRIDGE

ORG_NAME: ADA FORSYTH INSTITUTE, INC.

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because early childhood caries affects up to 90% of Indigenous North American children, and extreme socioeconomic disparities in oral health must be addressed. Successful completion of the proposed research could point to new preventive and therapeutic strategies for dental caries in high-risk populations.

PI_NAMEs: BIDLACK, FELICITAS B (contact);SHI, WENYUAN ;STARR, JACQUELINE R

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Acids;active control;Address;Affect;Aluminum;American;Bacteria;bacterial genetics;Basic Science;Binding;Biochemical;Cadmium;Carbohydrates;cariogenic bacteria;Cells;Child;Classification;commensal bacteria;crystallinity;Data;density;Dental caries;Dental Enamel;Dental Plaque;Dentin;Dimensions;early childhood;Elements;Epidemiology;Etiology;Exclusion;experimental study;Fermentation;Fingerprint;Gene Expression;Genes;Genomics;Goals;Grant;Growth;Hardness;high risk;high risk population;Histology;Hybrids;Image;Imaging Techniques;In Vitro;Indigenous;Indigenous American;innovation;insight;Knowledge;Lead;Legal patent;Mechanics;Methods;Microbe;microbial;Microbial Biofilms;Microbial Genetics;microbiome;microorganism interaction;mineralization;Minerals;Minority;Modeling;Molecular;Molecular Epidemiology;multidimensional data;multimodality;novel;Oral;oral bacteria;Oral cavity;oral commensal;Oral health;oral streptococci;Participant;Physiological;polymicrobial biofilm;Population;population based;Predisposition;prevent;Prevention strategy;Preventive;Production;Property;protective factors;Proteins;Public Health;Recording of previous events;Reproducibility;Research;Research Design;Resistance;resistance mechanism;Risk;Risk Factors;rRNA Genes;Saliva;saliva mediated;Salivary;Sampling;Science;Signal Transduction;socioeconomic disparity;Standardization;Statistical Data Interpretation;Streptococcus mutans;Structure;Sulfur;Taxon;Testing;Therapeutic;Time;Tissues;Tooth structure;transcriptomics

PROJECT_TITLE: Caries resistance mechanisms in high-risk Indigenous children


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Pediatric;Pediatric Cardiomyopathy;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE Pediatric cardiomyopathies (PCM) are rare but devastating disorders of the heart muscle with most children diagnosed before one year of age and limited treatment options often culminating in childhood death. The genetic underpinnings remain poorly understood and are complicated by patients carrying multiple genetic variants and by different variants in the same genes causing different types of PCM. Here we develop bioinformatic tools to prioritize the recently identified 343 PCM candidate genetic variants for modeling in the fly (Drosophila), followed by efficient “gene-level” and “variant-level” functional validation in the fly heart, to provide the much-needed in vivo data to confirm the causality of the candidate variants.

PI_NAMEs: HAN, ZHE  (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: 1 year old;Address;Adult;Affect;Alleles;Antibodies;bioinformatics tool;Biological Assay;Candidate Disease Gene;candidate identification;candidate validation;Cardiac;Cardiomyopathies;Cessation of life;Child;Childhood;Classification;Clinical;Communities;Complex;Data;Defect;Development;Diagnosis;Dilated Cardiomyopathy;disease mechanisms study;disease model;Disease Progression;disease-causing mutation;Drosophila genus;Dyes;early childhood;effective therapy;Etiology;exome sequencing;Family;Feedback;fly;Future;gain of function;Gene Combinations;gene function;gene replacement;Gene Silencing;Genes;Genetic;genetic architecture;Genetic Heterogeneity;genetic variant;Genotype;Goals;Heart;Heart Diseases;Heart Transplantation;Homologous Gene;Human;Hypertrophic Cardiomyopathy;improved;in silico;in vivo;Infant;Injections;insight;Libraries;loss of function;Modeling;mutant;Mutation;Myopathy;Nature;Neonatal Mortality;new technology;Newborn Infant;novel;Pathologic;Patients;Pediatric Cardiomyopathy;Phenotype;Proteins;Publishing;Rapid screening;Research;Research Personnel;RNA Interference;Sample Size;screening;Series;Stains;System;targeted treatment;Testing;tool;Transgenic Organisms;Uncertainty;Validation;Variant

PROJECT_TITLE: Screen and functional validation of Pediatric Cardiomyopathy genetic variants in Drosophila

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: NARRATIVE The goal of this research grant project is to define a neural circuit through which signals from gut bacteria modulate reward behaviors. This knowledge is a foundation to harness the therapeutic potential of gut microbes for disorders of metabolism, pain, and emotional well-being.

PI_NAMEs: BOHORQUEZ, DIEGO V (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: absorption;Acute;Animals;Bacteria;Behavior;Behavior Disorders;Biological Assay;Brain;Brain Stem;Calcium;Cells;Chemicals;Clinic;Colon;Communication;conditioned place preference;Data;design;Desire for food;detection of nutrient;Diet;dietary approach;Disease;Dissociation;Eating;Electrophysiology (science);Epithelial Cells;Epithelium;Fiber;Flagellin;food consumption;Foundations;gastrointestinal;Germ-Free;Goals;gut bacteria;gut health;gut microbes;Human;Hyperphagia;Immune signaling;improved;in vivo;Knock-out;Knowledge;Laboratories;Learning;Ligands;Link;Metabolic;Metabolic Diseases;Microbe;microbial;millisecond;Modeling;Molecular;Mus;Nervous System;neural;neural circuit;Neurons;neurotransmission;Nutrient;Obesity;optogenetics;Organoids;Pain;Pathway interactions;Pattern;Perfusion;Positive Valence;preference;Psyche structure;rabies label;rational design;receptor;reinforced behavior;Reporter;Research Project Grants;response;Rewards;Role;Route;Sensory;sensory mechanism;Signal Transduction;Small Intestines;Stimulus;sugar;Sweetening Agents;Synapses;System;Testing;Therapeutic;therapeutic target;Time;TLR5 gene;Transducers;Translating;Transplantation;Vagus nerve structure;Viral;Well in self;Work

PROJECT_TITLE: Bacteria sensory transduction from gut to brain to modulate behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-H(03)]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Congenital Structural Anomalies;Digestive Diseases;Gene Therapy;Genetics;Lung;Nanotechnology;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human

ORG_CITY: NEW HAVEN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Structural diseases diagnosed before birth, such as diaphragmatic hernia, cause significant morbidity in children due to tissue damage and inadequate organ development. Fetal therapy, to allow more normal organ development, through invasive procedures has demonstrated some benefit but more minimally invasive procedures are needed to allow for treatment earlier in pregnancy to further improve organ development. Synthetic nanoparticles, made from biocompatible polymers, serve as a platform to treat structural fetal diseases in a minimally invasive fashion and we will study these particles with the intent to treat fetal lung disease.

PI_NAMEs: SALTZMAN, W. MARK (contact);STITELMAN, DAVID

PROGRAM_OFFICER_NAME: CHEN, JERMONT

PROJECT_TERMS: Address;Amniocentesis;Amniotic Fluid;Animal Model;Animals;Behavior;Binding Proteins;biocompatible polymer;Biomedical Engineering;Birth;Blood Transfusion;Characteristics;Chemistry;Child;Childhood;Clinical;clinical translation;Congenital diaphragmatic hernia;Cystic Fibrosis;Data;design;Diagnosis;Diaphragmatic Hernia;Disease;disease diagnosis;disease phenotype;Early treatment;effective therapy;Effectiveness;Engineering;Environment;epigenetic therapy;Epithelium;Exposure to;Eye;fetal;fetal blood;Fetal Diseases;Fetal Lung;fetal medicine;Fetal safety;Fetal Tissues;Fetus;fetus surgery;gene therapy;Genes;Genetic Diseases;Goals;Growth;Hematopoietic stem cells;Hemoglobinopathies;Hospitals;Human;human fetus tissue;Image;Impairment;improved;improved outcome;in utero;Intervention;Intravenous;intravenous administration;Liquid substance;Lung;Lung Diseases;Medical;microRNA delivery;MicroRNAs;migration;minimally invasive;Modeling;Morbidity - disease rate;Morphology;mortality;nanoparticle;nanoparticle delivery;Nature;Needles;Operative Surgical Procedures;Organ;organ growth;Outcome;particle;Performance;Polymers;Pre-Clinical Model;Pregnancy;prenatal;prenatal therapy;prevent;Principal Investigator;Procedures;Proliferating;Proteins;Rattus;Rodent;Route;Safety;safety testing;Severities;Site;Spinal Cord;Spinal Dysraphism;stem cells;Structure of parenchyma of lung;success;Surface;Techniques;Testing;Therapeutic Agents;Time;Tissues;Translating;Translations;ultrasound;uptake;Work

PROJECT_TITLE: Engineering of Polymeric Particles for Fetal Therapy

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Malaria;Orphan Drug;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: PORTLAND

ORG_DEPT: CHEMISTRY

ORG_NAME: PORTLAND STATE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Malaria remains one of the major world public health problems, causing about 200 million clinical cases annually and claims nearly half a million lives, mostly children under the age of five and pregnant women. Both treating and preventing the malaria infection with novel drugs that kill the parasite in new ways is highly desirable and challenging. This project investigates a natural product inspired novel antimalarial prodiginine chemotype that is potent across the parasite life cycle with potential to prevent relapsing infections and possible novel mode(s) of action.

PI_NAMEs: KANCHARLA, PAPIREDDY  (contact);KELLY, JANE X;ROTH, ALISON

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: absorption;Age;Anti-malarials;Artemisinins;Attention;Biological Assay;Biological Availability;bioluminescence imaging;Blood;Cessation of life;chemical synthesis;Child;Clinical;combat;Combined Modality Therapy;cost;Cytochrome P450;Disease;DNA analysis;drug candidate;Drug Interactions;Drug Kinetics;Drug resistance;Effectiveness;Evaluation;genome analysis;genome sequencing;Genomic DNA;Glucosephosphate Dehydrogenase Deficiency;Goals;Half-Life;improved;In Vitro;in vivo;in vivo evaluation;Infection;Insecticide Resistance;Isoenzymes;iterative design;Lead;lead candidate;lead optimization;Life Cycle Stages;Liver;liver imaging;Malaria;malaria infection;Measurement;Metabolic;metabolic profile;Microsomes;Modeling;Molecular;Molecular Target;Morbidity - disease rate;mortality;natural product inspired;nonhuman primate;novel;novel therapeutics;Oral;Parasites;Patients;Permeability;Pharmaceutical Preparations;Plasmodium;Plasmodium berghei;Plasmodium cynomolgi;Plasmodium falciparum;Plasmodium vivax;Plasmodium yoelii;preclinical development;Pregnant Women;prevent;Prevention;process optimization;prodiginine;Production;Public Health;Relapse;relapse prevention;Research Project Grants;Resistance;Rodent;Safety;small molecule libraries;Solubility;Time;Toxic effect;Toxicity Tests;Tropical Disease;Vaccines;Validation;vector;whole genome;Work;World Health Organization

PROJECT_TITLE: Natural Product Inspired Novel Antimalarials with Radical Cure Potential

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-J(02)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: HANOVER

ORG_DEPT: PHYSIOLOGY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE This research proposal is relevant to public health because it addresses the molecular and cellular mechanisms through which the ASD-associated gene Pten alters neuronal function. Thus, it is directly relevant to the part of NIH’s mission outlined in PA-20-263- NIH Research Project Grant or PAR-20-263– Molecular and Cellular Substrates of Complex Brain Disorders.

PI_NAMEs: LUIKART, BRYAN W (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Ablation;Address;autism spectrum disorder;autism symptoms;base;Behavioral;Brain;Brain Diseases;cell immortalization;Cell Line;Cell Nucleus;Cellular biology;cognitive function;Complex;Coupled;Cytoskeleton;Dendrites;Development;Distal;Electrophysiology (science);emotional functioning;Equilibrium;Filopodia;FRAP1 gene;Functional disorder;Gene Expression;gene replacement;Genes;Genetic;genetic approach;genetic manipulation;Goals;Growth;Growth Cones;Growth Factor Receptors;Human;Image;in vivo;individuals with autism spectrum disorder;innovation;insight;Knock-out;knockout gene;Knockout Mice;Laboratories;Macrocephaly;Mediating;Microtubule Polymerization;migration;Mission;model of autism spectrum disorder;model organism;Molecular;Molecular Target;Morphology;mouse genetics;mouse model;Mus;Mutate;Mutation;neural circuit;Neurobiology;neuron development;neuronal cell body;neuronal growth;Neurons;neurophysiology;neurotrophic factor;newborn neuron;Pathway interactions;Patients;Phenotype;Phosphatidylinositols;Phosphoric Monoester Hydrolases;PIK3CG gene;polymerization;Polymers;Process;Protein Biosynthesis;Protein Dephosphorylation;Protein Tyrosine Kinase;PTEN gene;Public Health;Receptor Protein-Tyrosine Kinases;Regulation;Research;Research Project Grants;Research Proposals;Role;Signal Pathway;Signal Transduction;Social Behavior;Structure;Synapses;synaptic function;synaptogenesis;targeted treatment;Techniques;Testing;Translations;United States National Institutes of Health;Vinblastine;Viral

PROJECT_TITLE: The Impact of Pten Signaling on Neuronal Form and Function


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Physical Activity;Prevention

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE There is a critical need for effective nutritional strategies to limit energy intake and regulate appetite, and one such strategy that has gained increasing attention is time restricted eating (TRE), or restriction of food intake to a specific window of time during the day. The goal of this project is to evaluate the effects of a 52-week behavioral weight loss program using early vs. late timing of TRE as compared to standard of care (daily caloric restriction) on body weight and cardiometabolic outcomes. This project may result in changes in dietary recommendations and is therefore of significant benefit to public health.

PI_NAMEs: THOMAS, ELIZABETH ANNE (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Adherence;Adult;adult obesity;Attention;Behavior Therapy;Behavioral;blood lipid;Blood Pressure;Body Composition;Body Weight;Body Weight Changes;Body Weight decreased;Caloric Restriction;cardiometabolism;Clinical Data;clinically significant;Control Groups;design;Desire for food;Diet;dietary;dietary adherence;Dietary Intervention;dietary restriction;Eating;Effectiveness;effectiveness evaluation;Energy Intake;evidence base;Failure;Fatty acid glycerol esters;follow-up;food restriction;Glucose;Goals;Guidelines;Health;improved;improvement on sleep;Individual;insight;insulin sensitivity;Intervention Trial;Literature;Metabolic;novel;Nutritional;Obesity;obesity treatment;Outcome;Overweight;Participant;Persons;Physical activity;Pilot Projects;pre-clinical;primary outcome;Public Health;Randomized;Recommendation;Sample Size;sedentary;Sleep;standard of care;Time;Time-restricted feeding;treatment guidelines;trial design;Weight;weight loss program

PROJECT_TITLE: Effects of early vs. late time restricted eating vs. daily caloric restriction on weight loss and metabolic outcomes in adults with obesity

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Health Relevance HIV-1 infection to non-dividing myeloid cells, such as macrophages and microglia (brain macrophages), contributes to HIV-1 pathogenesis. Particularly, HIV-1 infected macrophages serve as a key long-living viral reservoir that persistently produces viral progenies even during the course of intense antiviral therapy. This application attempts to elucidate novel regulatory circuits of a host defense mechanism executed by a host restriction factor, SAMHD1, that kinetically delays multiple steps of HIV life cycle in nondividing viral target cell types, ultimately providing new anti-HIV target strategies that effectively suppress HIV-1 life cycle in non- dividing myeloid cells that contribute to HIV-1 persistence and neuro-AIDS.

PI_NAMEs: KIM, BAEK  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Anabolism;Anti-viral Therapy;Binding;Biological Assay;Brain;Caenorhabditis elegans;CD4 Positive T Lymphocytes;CDC2 gene;CDK2 gene;cell type;Cells;Consumption;Cryoelectron Microscopy;cyclin A2;DNA biosynthesis;Drosophila genus;Engineering;enzyme biosynthesis;Exposure to;Health;HIV;HIV-1;HIV-2;Homeostasis;Host Defense Mechanism;Human;Infection;inhibitor;Interphase Cell;Investigation;Kinetics;Lentivirus;Life Cycle Stages;Macrophage;Mediating;Metabolic;Metabolism;meter;Microglia;Mitotic;Modeling;Molecular;monocyte;multicatalytic endopeptidase complex;Myelogenous;Myeloid Cells;Nature;neuroAIDS;novel;Orthologous Gene;Pathogenesis;Phosphoric Monoester Hydrolases;Phosphorylation;prevent;Protein Dephosphorylation;Protein Phosphatase 2A Regulatory Subunit PR53;Proteins;Regulation;Reporting;Reverse Transcription;Ribonucleotide Reductase;Role;SAM Domain;SIV;Tail;Viral;Viral Proteins;Viral reservoir;X-Ray Crystallography

PROJECT_TITLE: SAMHD1 mediated dNTP regulation and HIV in myeloid cells


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Social Determinants of Health;Stroke

ORG_NAME: NORTHERN CALIFORNIA INSTITUTE/RES/EDU

PHR: Narrative  We need to enhance our collective ability to reduce the overall immense burden of stroke on society, and its disproportionate toll on key sociodemographic groups. The goal of this one-day annual symposium over 4 years is to partner with the pre-eminent national stroke society to encourage more research into disparities around stroke, by providing leading edge science aimed particularly at scientists from various professional and scientific disciplines, with an interest in disparities research. Special efforts will be made to sponsor some early career scientists and invite under-represented in medicine minority and women scholars to participate.

PI_NAMEs: OVBIAGELE, BRUCE  (contact)

PROGRAM_OFFICER_NAME: BENSON, RICHARD T

PROJECT_TERMS: Acceleration;Achievement;Address;Affect;American Stroke Association;Award;Awareness;career;career development;Caring;Cause of Death;Cerebrovascular Disorders;Clinical Trials;cohort;Collaborations;Colorado;Communication;Communities;community burden;community engagement;Community Outreach;Death Rate;Dedications;Dementia;Development;Dimensions;disability;Discipline;Disparity;disparity reduction;Diverse Workforce;economic cost;Education;effectiveness evaluation;ethnic minority;Ethnic Origin;Event;experience;Faculty;Feedback;Financial Support;Fostering;Future;Geography;Goals;health equity;Human Resources;implementation intervention;implementation science;improved;improved outcome;Individual;interest;International;Intervention;Intervention Studies;Journals;Knowledge;Logistics;Los Angeles;low income country;Measurement;medical schools;Medicine;meetings;Mental Depression;Mentors;Minority;minority scientist;multidisciplinary;next generation;Outcome;outcome disparities;Patients;Persons;Policy Maker;Policy Making;Population;population health;Positioning Attribute;Postdoctoral Fellow;posters;Prevalence;Problem Solving;programs;Provider;Public Health;Publications;Race;racial minority;Recovery;Research;research and development;Research Personnel;Resources;rural dwellers;scale up;Schedule;Scholarship;Science;Scientist;Seasons;sex;social media;Societies;sociodemographic group;socioeconomic disadvantage;socioeconomics;Southeastern United States;Stroke;stroke incidence;stroke model;stroke outcome;Stroke prevention;success;symposium;Testing;Training;Translating;translational physician;Translational Research;translational scientist;Travel;United States;United States National Institutes of Health;virtual;volunteer;Woman;Work

PROJECT_TITLE: Health Equity & Actionable Disparities in Stroke: Understanding & Problem-solving (HEADS-UP) Symposium


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: Congenital defects of the outflow tract are clinically serious but poorly understood. This project applies innovative experimental technology and computational analysis to elaborate novel molecular switches that govern how mechanical forces drive endocardial-mesenchymal collective signaling in the outflow tract by potentiating growth vs. maturation programs in the outflow tract.

PI_NAMEs: BUTCHER, JONATHAN TALBOT (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Ablation;Acute;Affect;antagonist;aortic valve;arm;Automobile Driving;Back;Birds;Birth;Cardiac;Cells;Chick;Chronic;Circulation;Clinical;clinically relevant;cohort;Collaborations;Complement;Complex;Computer Analysis;Congenital Abnormality;Congenital Heart Defects;Data;Defect;Distal;Echocardiography;Embryo;Endocardium;Environment;Esthesia;Etiology;Event;Failure;Felis catus;fetal;Fetal Death;Fetal Growth;Future;Genes;Genetic;genetic approach;Growth;hemodynamics;Human;In Situ;in utero;in vivo;innovation;innovative technologies;insight;Lasers;Liquid substance;Live Birth;Lung;malformation;mechanical force;Mechanical Stress;Mechanics;mechanotransduction;Mesenchymal;Mesenchyme;Modeling;Molecular;Morphogenesis;morphogens;Morphology;Mutant Strains Mice;novel;operation;Organ Culture Techniques;Pattern;Phase;Phenotype;Physical condensation;pressure;Process;programs;Proliferating;protein expression;Regulator Genes;Resolution;Resources;response;RNA;Role;Severities;Shapes;shear stress;Signal Transduction;Slide;spatiotemporal;Stratification;Stress;stress state;Technology;Testing;tissue stress;Tissues;transcriptomics;ultrasound;Visualization;Zebrafish

PROJECT_TITLE: Mechanobiology of Cardiac Outflow Tract Morphogenesis

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project Narrative  Genome Wide Association Studies (GWAS) have identified over 100 loci contributing to the risk of Atrial Fibrillation, however, the molecular mechanisms underlying their genetic implication remains unknown. We propose to apply a novel single cell genomic and analytic approach to identify causative risk variants and their target genes, analyze the molecular basis of the risk loci, and interrogate several risk SNPs in detailed molecular, genomic, and electrophysiological studies in human cardiomyocytes. The results will generate biological insight from genetic implication, delivering a greater understanding of the genetic basis of Atrial Fibrillation.

PI_NAMEs: HE, XIN ;MOSKOWITZ, IVAN PAUL (contact);POTT, SEBASTIAN

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Address;Adult;Affect;Alleles;Arrhythmia;Atrial Fibrillation;Biological;Biological Assay;candidate identification;Cardiac;Cardiac Myocytes;causal variant;Cell Physiology;cell type;Cells;Cellular Structures;Chromatin;chromosome conformation capture;Chromosomes;Complex;Data;Data Set;deep learning;Disease;disorder risk;DNA;economic cost;Electrophysiology (science);Enhancers;Etiology;experimental study;Functional disorder;gene discovery;Gene Expression;Gene Expression Regulation;gene regulatory network;Gene Targeting;Genes;Genetic;genetic association;genetic variant;Genetic Variation;genome wide association study;genomic data;Genomics;Goals;Heart;Heart Atrium;Human;improved;In Vitro;Individual;insight;Link;Maps;Modeling;Molecular;multimodality;novel;Nucleic Acid Regulatory Sequences;Pathway interactions;Physiology;Pilot Projects;Principal Investigator;Procedures;promoter;Regulatory Element;Reporter;Resolution;Risk;risk variant;Signal Transduction;single cell ATAC-seq;single cell genomics;socioeconomics;System;Techniques;Tissues;trait;transcription factor;transgene expression;Translating;Untranslated RNA;Variant

PROJECT_TITLE: Discovery and interrogation of genetic regulatory variation impacting Atrial Fibrillation risk

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Precision Medicine

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE: Targeting of the EGF receptor with therapeutic antibodies like cetuximab (and panitumumab) is clinically used in advanced colorectal cancer, however, cetuximab resistance is nearly universal. Our work with three dimensional cultures of CRC cell lines and normal colon and patient-derived tumor xenografts and organoids identified two new modes of resistance to cetuximab that was driven by activation of multiple receptor tyrosine kinases. In this application we propose to identify, characterize, and prevent/overcome these and new resistance mechanisms in CRC with the aim to improving patient selection and efficacy of personalized medicine.

PI_NAMEs: SINGH, BHUMINDER  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: 3-Dimensional;Address;Antibodies;Biological Markers;BRAF gene;Cancer Etiology;Cancer Model;Cessation of life;Cetuximab;Chemicals;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collagen Type I;Colon;colon cancer cell line;Colorectal Cancer;colorectal cancer progression;colorectal cancer treatment;crizotinib;Drug Combinations;Effectiveness;Epidermal Growth Factor Receptor;ERBB3 gene;Exclusion;Exhibits;experimental study;Gene Expression Profile;Genetic;Grant;High Prevalence;Human;Hypersensitivity;imaging probe;Immunocompetent;improved;In Vitro;in vitro Model;in vivo;in vivo Model;inclusion criteria;Individual;inhibitor;Knock-out;KRAS2 gene;Ligands;Link;MAP Kinase Gene;Mediating;Modification;Monoclonal Antibodies;Morphology;Mus;Mutation;Neoplasm Metastasis;neutralizing antibody;non-genetic;novel;NRG1 gene;Nude Mice;Oncogenic;Operative Surgical Procedures;Organoids;overexpression;panitumumab;patient derived xenograft model;patient population;Patient Selection;patient stratification;Patients;personalized medicine;pharmacologic;Pharmacotherapy;Phase I/II Clinical Trial;Phenotype;Phosphorylation;Play;Positron-Emission Tomography;precision medicine;predicting response;Prevalence;prevent;Prognosis;Progression-Free Survivals;Proteins;Ras/Raf;Reaction;receptor;Receptor Protein-Tyrosine Kinases;Receptor Up-Regulation;receptor upregulation;Research;Research Design;Research Personnel;Resistance;resistance mechanism;Resistance profile;response;Role;Sampling;Signal Pathway;Signal Transduction;small molecule inhibitor;Southeastern United States;System;targeted treatment;Testing;Therapeutic antibodies;Therapeutic Monoclonal Antibodies;therapeutic target;Tissue Microarray;treatment response;treatment strategy;tumor;Tumor Tissue;tumor xenograft;Tyrosine Kinase Inhibitor;Tyrosine Kinase Receptor Inhibition;Tyrosine Phosphorylation;United States;Unresectable;uptake;Work;Xenograft procedure

PROJECT_TITLE: Role of Receptor Tyrosine Kinase cross-talk in colorectal cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Digestive Diseases;Food Allergies;Nutrition

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE While eosinophilic esophagitis (EoE) is known to be primarily triggered by food antigens, the mechanisms underlying this food-induced inflammation remain unknown. We expect to demonstrate that IgG4 forms immune complexes with food and stimulates local immune cells in EoE, thereby contributing to food-induced inflammation in this disease. Characterizing the role of IgG4 in EoE could lead to a paradigm shift in our understanding of this condition, as well as novel diagnostic and treatment approaches.

PI_NAMEs: MCGOWAN, EMILY CLARKE (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Address;Allergic;Allergic Disease;Anti-Inflammatory Agents;antigen binding;Antigen Presentation;Antigen-Antibody Complex;Avidity;Biological Assay;Biopsy;Cell Communication;Cells;Co-Immunoprecipitations;Coculture Techniques;Data;Dendritic cell activation;Dendritic Cells;Deposition;Detection;Development;Diagnostic tests;Diet;Disease;Disease remission;eosinophil;Eosinophilic Esophagitis;Epithelium;Esophageal Tissue;Esophagus;Flow Cytometry;Food;food allergen;food antigen;Functional disorder;gastrointestinal;Generations;Goals;IgE;Immune;Immune response;Immunofluorescence Immunologic;Immunoglobulin G;Immunoglobulins;In Vitro;in vitro Assay;in vivo;indexing;individual patient;Infiltration;Inflammation;insight;Knowledge;mast cell;Milk;Milk Proteins;Modeling;Monoclonal Antibodies;Morbidity - disease rate;novel;novel diagnostics;Optics;Outcome;Pathogenesis;Patients;Phenotype;Population;Positioning Attribute;Production;Proteins;Proteomics;response;Role;success;T cell response;T-Cell Activation;T-Lymphocyte;Techniques;Testing;Tissues;TSLP gene;Wheat

PROJECT_TITLE: Defining the Role of Immunoglobulin G4 (IgG4) in Food-Induced Eosinophilic Esophagitis (EoE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDB-K(57)]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Rare Diseases

ORG_CITY: RICHMOND

ORG_DEPT: DENTISTRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: Public Health Relevance Statement Epidermal Growth Factor Receptor (EGFR) and Hippo signaling play critical roles in the development of many types of cancers. The current proposal will explore a novel function of a phosphoinositide kinase in the control of EGFR and Hippo signaling, and will test its role in head and neck squamous cell carcinoma (HNSCC) progression. The control of this kinase will lead to novel strategies to treat HNSCC.

PI_NAMEs: SUN, YUE  (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: 1-Phosphatidylinositol 4-Kinase;Attention;Biological;Biological Assay;Biological Process;cancer stem cell;cancer type;Cell Differentiation process;cell growth;Cell Line;Cell membrane;Cell Nucleus;Cell Proliferation;Cells;Data;design;Development;Down-Regulation;Early Endosome;Endosomes;Enzymes;Epidermal Growth Factor Receptor;Event;Exhibits;Genetic Transcription;Growth;Head and Neck Squamous Cell Carcinoma;In Vitro;in vivo;inorganic phosphate;Invaded;Knockout Mice;Laboratories;LATS2 gene;Link;Lipids;Lysosomes;Malignant Neoplasms;Mammalian Cell;Mediating;migration;Modeling;Molecular;Monomeric GTP-Binding Proteins;mouse model;Neoplasm Metastasis;Neurons;novel;novel strategies;Oncogenes;Pathologic;Pathway interactions;Patients;Phosphatidylinositol 4,5-Diphosphate;phosphatidylinositol phosphate 4-kinase;Phosphatidylinositol Phosphates;Phosphatidylinositols;Phosphotransferases;Play;precursor cell;prevent;Proteins;PTEN gene;public health relevance;Publishing;Receptor Protein-Tyrosine Kinases;Receptor Signaling;recruit;Regulation;Research;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Sorting;stem cell biomarkers;stem cell self renewal;System;Testing;trafficking;Transcription Coactivator;Transportation;tumor;tumor progression;tumorigenesis;ubiquitin-protein ligase;Ubiquitination;Work;Xenograft procedure

PROJECT_TITLE: PIPKIgammai5 in the Control of HNSCC Progression

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Genetics;Precision Medicine;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative: Abnormal white patches of tissue in the mouth, or leukoplakias, are common and may become cancerous over time. This project aims to understand what events make these patches arise, and if we can predict which ones might go on to become cancer. This will permit us better select which people need treatment, as well as possible treatment strategies for these white patches.

PI_NAMEs: TWARD, AARON  (contact)

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: Address;Biological Markers;Biological Models;Biopsy;Biopsy Specimen;Cancer cell line;Cancerous;causal variant;CDKN2A gene;Cell Reprogramming;Cell Separation;Classification;clinical application;Clustered Regularly Interspaced Short Palindromic Repeats;Cold Therapy;Communities;Data;data resource;deep sequencing;Disease;driver mutation;Dysplasia;Engineering;Event;Excision;FDA approved;flexibility;Future;gene editing technology;Genes;Grant;Growth;Head and Neck Cancer;Human;Hybrids;In Vitro;Individual;individual patient;individual response;keratinocyte;Knowledge;Lesion;Leukoplakia;Low-Level Laser Therapy;Maintenance;Malignant Epithelial Cell;Malignant Neoplasms;Mediator;Modeling;Molecular;Monitor;mouth squamous cell carcinoma;Mutation;mutational status;Natural History;Neoplasms;neoplastic;next generation sequencing;novel;novel therapeutic intervention;novel therapeutics;Oral;Oral cavity;oral dysplasia;Pathogenesis;Pathologic;patient subsets;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Phenotype;Phototherapy;precision medicine;Precision therapeutics;predictive marker;premalignant;Prevalence;Protein Analysis;Recurrence;Research;Resolution;response;Retinoids;Signal Transduction;Squamous cell carcinoma;standard of care;success;System;Testing;Therapeutic;Time;Tissues;transcriptome sequencing;treatment strategy;tumor progression;Uncertainty;United States;Validation;Work

PROJECT_TITLE: Defining the mutational pathogenesis of oral preneoplasia

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Rare Diseases

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: Program Narrative Cancers remain the second leading cause of death in the United States with head and neck carcinomas being the sixth most common cancer worldwide. Within this group, mucoepidermoid carcinomas (MEC) are the most common type of malignant salivary gland cancer and the CRTC1/MAML2 (C1/M2) gene fusion arising from a t(11;19)(q21;p13.1) chromosomal translocation is pathognomonic for MEC, and drives aberrant co-activation of the transcription factors CREB and MYC. Using a combination of validated xenograft and genetically engineered mouse models of C1/M2-driven MEC, we will apply our cutting-edge optical reporter technology to systematically and comprehensively define the role of CREB and MYC in coordinating transcriptional programs that drive development and maintenance of salivary MEC, which will enhance our understanding of this disease process and provide an opportunity to develop targeted therapies.

PI_NAMEs: AMELIO, ANTONIO LUIGI (contact)

PROJECT_TERMS: Address;Agonist;Automobile Driving;Binding;Biochemical;Bioinformatics;Cause of Death;Cell Differentiation process;Cells;Characteristics;ChIP-seq;Chromatin;Chromosomal translocation;clinical diagnostics;clinically significant;conventional therapy;CREB1 gene;Custom;Data;Development;Disease;Disease Progression;DNA;Drug resistance;E-Box Elements;Enhancers;epithelial to mesenchymal transition;Equilibrium;Etiology;Event;gain of function;Gel;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Gene Fusion;Genes;Genetic;genetic approach;Genetic Transcription;Genetically Engineered Mouse;Gland;Growth Factor;Head and Neck Cancer;Heterogeneity;Human;human disease;in vitro Assay;in vivo;innovation;Insulin;Insulin-Like Growth Factor I;knock-down;Knowledge;Link;Maintenance;Major Groove;Malignant - descriptor;Malignant neoplasm of salivary gland;Malignant Neoplasms;malignant state;Mass Spectrum Analysis;Mediating;MLL/ELL;Molecular;mouse model;Mucoepidermoid Carcinoma;Mus;National Institute of Dental and Craniofacial Research;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;Oncogenes;Oncogenic;Oncoproteins;Optical reporter;Pathologic;Pathology;Patients;pharmacologic;Phenotype;pluripotency factor;Population;Post-Translational Protein Processing;Prevalence;Primary Neoplasm;Process;Prognosis;programs;promoter;Property;Recurrence;Recurrent disease;Recurrent tumor;Regulation;Residual Neoplasm;Resistance;Role;Salivary;Salivary Gland Neoplasms;Sampling;Signal Pathway;Signal Transduction;single-cell RNA sequencing;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Intervention;Tissue Microarray;Tissues;tool;Transcription Coactivator;transcription factor;transcriptome sequencing;treatment response;tumor;tumor heterogeneity;tumor initiation;tumor microenvironment;Tumor Promotion;tumor xenograft;tumorigenesis;Undifferentiated;United States;United States National Institutes of Health;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Role of CRTC1-MAML2 in Salivary Mucoepidermoid Carcinoma Pathobiology


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Understanding the mechanisms by which cells transport and position intracellular organelles is crucial for defining normal physiology and a wide range of diseases. Our research team is taking an integrative approach to understand this problem, with the goal of achieving an atomic- to-cellular-to-in vivo level understanding of the mechanisms of organelle transport. The roles of spatial organization and dynamic assembly of filaments, mechanical forces, motor activity, and other regulatory elements will be investigated.

PI_NAMEs: DOMINGUEZ, ROBERTO ;HOLZBAUR, ERIKA L;LAKADAMYALI, MELIKE ;OSTAP, E. MICHAEL (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Actins;Adhesions;Automobile Driving;Biochemistry;Biological Models;Biophysics;cell growth regulation;Cells;Cellular biology;Classification;cofactor;Complement;Complex;Computational Biology;Computer Models;Cytoskeletal Filaments;Cytoskeletal Proteins;Cytoskeleton;Degradation Pathway;Disease;Drosophila genus;Dynein ATPase;Endosomes;Filament;genetic regulatory protein;Goals;In Vitro;in vivo;Interdisciplinary Study;Kinesin;Kinetics;mechanical force;Mechanics;Membrane;microsystems;Microtubules;Mitochondria;Modeling;Molecular;Molecular Motors;Motility;Motor;Motor Activity;Myosin ATPase;nanomachine;organelle movement;Organelles;Organism;Physiological;Physiology;Pilot Projects;Positioning Attribute;professional atmosphere;programs;reconstitution;Regulation;Regulatory Element;Research;Research Personnel;Role;Signal Pathway;single molecule;structural biology;Structure;Support System;Testing

PROJECT_TITLE: Integrative mechanisms of organelle dynamics from the atomic-to-cellular level


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

PHR: Project Narrative: 2-3 sentences The diagnosis of drug resistant tuberculosis remains a challenge, especially when the genetic mutations associated with resistance are not completely known, as with the new drugs. We will develop a new rapid test that will speed the detection of resistant tuberculosis in sputum and in culture, enabling early initiation of effective anti-tuberculosis treatment, improving patient outcomes and curtailing spread of drug resistant TB.

PI_NAMEs: KATO-MAEDA, MIDORI  (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Address;Antibiotics;Antitubercular Agents;biobank;Biological Assay;Biological Markers;Cells;Clinical;Clinical Sensitivity;Collection;Colony-forming units;Country;Culture Media;Data;Detection;detection limit;Diagnosis;DNA Sequence Alteration;Drug Exposure;Drug resistance;Drug resistance in tuberculosis;Early Diagnosis;effective therapy;Enzyme Immunoassay;Epidemic;Fluoroquinolones;Goals;Growth;Hour;immunogenic;improved;in vitro Assay;Infrastructure;innovation;Intermediate resistance;isoniazid;Isoniazid resistance;Japan;Laboratories;Linezolid;Liquid substance;Measures;Methods;Molecular;Mutation;Mycobacterium tuberculosis;novel;novel therapeutics;Oral;Patient-Focused Outcomes;Patients;Performance;Pharmaceutical Preparations;Phenotype;Philippines;Predisposition;prospective;Protein Secretion;Protocols documentation;Pulmonary Tuberculosis;rapid technique;rapid test;Regimen;Resistance;Resistance profile;Rifampin;Sampling;Sensitivity and Specificity;Specificity;Speed;Sputum;Testing;Time;Tuberculosis;tuberculosis drugs;tuberculosis treatment;Validation;World Health Organization

PROJECT_TITLE: Innovating anti-tuberculosis drug susceptibility testing with a novel and rapid non-culture based phenotypic test using MPT64 biomarker


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Immunotherapy;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: CHARLESTON

ORG_DEPT: SURGERY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative: The goal of this study is to determine the safety and efficacy of fresh metabolically active allogeneic umbilical cord-derived mesenchymal stromal/stem cells (UC-MSCs) for the treatment of new onset type 1 diabetes (T1D) and to understand any mechanisms of protection. If proven effective, such strategy can be used as a therapeutic option for T1D patients and potentially other autoimmune disorders.

PI_NAMEs: WANG, HONGJUN  (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Adult;adult stem cell;Aftercare;Age;Allogenic;Area Under Curve;Attenuated;Autoimmune;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;Autologous;autoreactive B cell;Beta Cell;Biological Markers;Bone Marrow;C-Peptide;CD80 gene;CD86 gene;Cell Count;Cell Death;Cell Physiology;Cell Therapy;Cells;clinical center;Clinical Data;Clinical Treatment;Clinical Trials;cytokine;Data;Diabetes Mellitus;Disease;DNA;Dose;Double-Blind Method;efficacy evaluation;Enrollment;experience;Fatty acid glycerol esters;Funding;Goals;Grant;Harvest;Hyperglycemia;Immune;Immune response;Immune system;immune system function;immunoregulation;Immunosuppression;Immunotherapy;improved;Inbred NOD Mice;Inflammatory;Infrastructure;Infusion procedures;Institution;insulin dependent diabetes mellitus onset;insulin secretion;Insulin-Dependent Diabetes Mellitus;Interdisciplinary Study;Interleukin-2;Intervention;islet;Lupus;Measures;Mesenchymal Stem Cells;Metabolic;MHC Class II Genes;Morbidity - disease rate;mouse model;mRNA Expression;Natural regeneration;Newly Diagnosed;Pancreas;Pancreatic Injury;participant enrollment;Patient Recruitments;patient retention;Patients;Peripheral Blood Mononuclear Cell;Placebo Control;Placebos;Plastic Surgical Procedures;pre-clinical;preconditioning;preservation;Procedures;Proliferating;Property;Randomized;receptor;regeneration potential;regenerative;Regulatory T-Lymphocyte;Reperfusion Injury;Reporting;response;Running;Safety;safety and feasibility;Serious Adverse Event;Serum;Signal Transduction;Source;standard of care;stem cell expansion;stem cell migration;stem cell therapy;Structure of beta Cell of islet;Sweden;Testing;Th2 Cells;Therapeutic;Tissues;Transforming Growth Factor beta Receptors;Umbilical cord structure;United States;Wound healing therapy

PROJECT_TITLE: Cellular Therapy for Type 1 Diabetes using Mesenchymal Stem Cells

STUDY_SECTION: CIDO

STUDY_SECTION_NAME: Clinical and Integrative Diabetes and Obesity Study Section[CIDO]


NIH_SPENDING_CATS: Cancer;Genetics;Radiation Oncology

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: NARRATIVE Nonhomologous end joining is a pathway for repair of chromosomal DNA double strand breaks, and determines the effectiveness of many cancer therapies, including ionizing radiation. This repair pathway surprisingly often repairs our DNA with elements of RNA; here we propose to investigate how RNA in our DNA chromosomes is then removed, with a focus on therapeutically relevant circumstances. We will additionally work to better understand how clinically employed inhibitors of nonhomologous end joining function in cells.

PI_NAMEs: RAMSDEN, DALE A (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: adaptive immunity;Antigen Receptors;Biological Assay;Blood group antigen S;BRCA deficient;BRCA1 gene;cancer therapy;candidate identification;Cells;Chromosomal Breaks;Chromosomes;Clinical;Complex;Data;DNA;DNA Double Strand Break;DNA Primase;DNA Repair Inhibition;DNA Repair Pathway;DNA-Directed DNA Polymerase;Double Strand Break Repair;Effectiveness;effectiveness evaluation;Elements;Excision;Genetic;Genome;Genome Stability;Genomic Instability;Hereditary Breast Carcinoma;Immune system;Immunoglobulins;Impairment;improved;inhibitor;insight;Ionizing radiation;Ligation;Malignant Neoplasms;Maps;Metabolism;Methods;Modeling;Nonhomologous DNA End Joining;Nucleotides;p53-binding protein 1;Pathway interactions;Polymerase;Publishing;Radiation therapy;receptor;Receptor Gene;repaired;Research;Resected;RNA;RNA primers;RNA replacement;Role;small molecule inhibitor;Specificity;T-Cell Receptor;Therapeutic;therapeutic candidate;Time;treatment response;Work

PROJECT_TITLE: DNA Polymerases in Nonhomologous End Joining


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Disease;Nutrition;Obesity;Orphan Drug;Rare Diseases

ORG_CITY: INDIANAPOLIS

ORG_DEPT: GENETICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE Non-alcoholic fatty liver disease (NAFLD) currently affects 1 in 4 individuals in the USA, and is a leading cause of liver transplantation; no FDA-approved treatments are available. Aberrant transcriptional control of gene expression constitutes a central aspect of the pathophysiology of NAFLD. Using state-of-the-art high- throughput technologies, this research will generate key information on a fundamental mechanism of transcription control, and will facilitate the future development of drug therapies directed at correcting dysregulated gene expression.

PI_NAMEs: MORRAL, NURIA  (contact)

PROJECT_TERMS: Acetylation;Address;Affect;Automobile Driving;Biological;Carbohydrates;Cells;Chromatin;chronic liver disease;Cirrhosis;Complex;Cues;Data;Development;diet-induced obesity;drug development;Drug Targeting;Environment;EP300 gene;Fasting;Fatty acid glycerol esters;FDA approved;feeding;Functional disorder;Future;Gene Expression;Gene Expression Regulation;Gene Silencing;Genes;Genetic;Genetic Transcription;genome-wide;Glucose;Goals;Hepatocyte;high throughput technology;High-Throughput Nucleotide Sequencing;histone acetyltransferase;Histone H3;Homeostasis;Human;Individual;innovation;Insulin;Insulin Resistance;Investigation;leukemia;lipid biosynthesis;Lipids;Liver;liver transplantation;Malignant neoplasm of liver;malignant phenotype;Mediating;Metabolic Diseases;Metabolism;Modeling;Modification;Molecular;Mus;negative elongation factor;new therapeutic target;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;novel;Nutrient;Nutrient availability;obese person;Obesity;obesity treatment;Pharmacotherapy;Prevalence;Process;Production;programs;promoter;public health relevance;recruit;Regulation;Research;response;Risk Factors;RNA;RNA Polymerase II;Role;SCAP protein;Signal Transduction;simple steatosis;SRE-1 binding protein;Steatohepatitis;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;Transcript;Transcription Elongation;transcription factor;Transcription Initiation;Transcriptional Regulation

PROJECT_TITLE: Transcription cycle regulation by nutrients

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Esophageal Cancer;Genetics;Human Genome;Rare Diseases

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECT NARRATIVE This proposal will use genome-wide approaches to investigate transcription-coupled DNA repair in eukaryotes. Studies proposed in this application will help us understand mechanisms of the neurological disorder Cockayne syndrome (CS) and cancer mutagenesis.

PI_NAMEs: MAO, PENG  (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: Address;Alkylation;Apoptosis;ATP phosphohydrolase;base;Base Excision Repairs;Binding;cancer genome;Cells;Chromatin;chromatin remodeling;Cockayne Syndrome;Code;Complex;Coupled;Coupling;Data;DNA;DNA Damage;DNA lesion;DNA mapping;DNA Repair;DNA-Directed DNA Polymerase;DNA-Directed RNA Polymerase;Elongation Factor;Esophageal Adenocarcinoma;Esophageal Neoplasms;Eukaryota;Excision;Foundations;Genes;Genetic Transcription;Genome;genome-wide;Human;Human Genome;improved;innovation;insight;Investigation;Knowledge;Lesion;Malignant Neoplasms;Maps;Mediating;Methods;methylpurine;Molecular Conformation;Mutagenesis;mutant;Mutation;Mutation Analysis;Nervous System Disorder;Nucleosomes;Nucleotide Excision Repair;Nucleotides;Orthologous Gene;Outcome;oxidative damage;oxidative DNA damage;Pathway interactions;Peptide Initiation Factors;Play;Polymerase;prevent;Proteins;Pyrimidine Dimers;Reaction;recruit;Repair Complex;repair enzyme;repaired;Research;Resolution;RNA Polymerase II;Role;Somatic Mutation;SWI2/SNF2;Testing;transcription factor TFIIH;Transcription Initiation;Transcription-Coupled Repair;Transcriptional Elongation Factors;ultraviolet damage;UV induced;yeast genome;Yeasts

PROJECT_TITLE: Mechanism of Transcription-coupled DNA Repair and its Impact on Cancer Mutations

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Neurodegenerative;Neurosciences;Pain Research;Patient Safety;Peripheral Neuropathy;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE The findings from this study will help determine the efficacy of yoga for reducing chemotherapy- induced peripheral neuropathy pain when compared to education and usual care control groups. It will also help evaluate yoga’s effect on improving quality of life, sensory nerve recovery, and reducing the risk of falls. The study findings may contribute to identification of a non- pharmacological method to improve patients’ quality of life and prevent falls.

PI_NAMEs: BAO, TING  (contact)

PROGRAM_OFFICER_NAME: SAMIMI, GOLI

PROJECT_TERMS: Adverse effects;Affect;afferent nerve;American Society of Clinical Oncology;arm;Attention;Brief Pain Inventory;Cancer Center;Cancer Patient;Cancer Survivor;cancer therapy;care providers;chemotherapy;Chemotherapy-induced peripheral neuropathy;Clinical;Clinical Trials;Clinical Trials Design;Complication;Controlled Clinical Trials;Data;disability;Disabling;duloxetine;Education;effective therapy;efficacy evaluation;Equilibrium;experience;Fall prevention;fall risk;Fatigue;Fiber;flexibility;functional improvement;functional outcomes;global health;Goals;Gynecologic Oncology Group;Headache;improved;Information Systems;Intervention;Longterm Follow-up;Malignant Breast Neoplasm;Malignant Female Reproductive System Neoplasm;Measurement;Measures;meetings;Methods;Mind-Body Intervention;minimally invasive;multidisciplinary;Muscle;National Cancer Institute;Nausea;neurotoxic;neurotoxicity;Nonpharmacologic Therapy;Numbness;Numeric Rating Scale;Pain;pain reduction;Participant;Patient Outcomes Assessments;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Physical therapy;Pilot Projects;Placebos;Prevention;primary endpoint;primary outcome;Quality of life;Questionnaires;Randomized;Randomized, Controlled Trials;Recommendation;Recovery;Research;Risk Reduction;Scientist;secondary endpoint;Sensory;Severities;side effect;standard of care;Symptoms;Testing;treatment as usual;Treatment-related toxicity;trial comparing;trial planning;two-arm trial;United States;usual care arm;Yoga

PROJECT_TITLE: Yoga for Chemotherapy-induced Peripheral Neuropathy Treatment (YCT) Trial

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Recent theories suggest that failures of self-control, which are a fundamental part of human behavior and are often triggered by exposure to stress, may emerge because self-control is perceived to be effortful (or ‘costly’) to individuals. Here, we use behavioral, computational and neuroimaging approaches to quantify these self- control costs, identify how they are represented in the brain and examine how they change under different forms of stressor exposure. Identifying behavioral metrics and neural mechanisms for the cost of self-control may offer a more precise approach for predicting when and how stress will compromise self-control processes and further our understanding of self-control failure, which is a transdiagnostic feature across a range of psychiatric disorders.

PI_NAMEs: RAIO, CANDACE M (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: access restrictions;Address;Affect;Affective;Anterior;Behavior;Behavior Control;Behavioral;behavioral response;biological adaptation to stress;Biological Assay;Brain;Brain region;Buffers;Choice Behavior;cingulate cortex;Clinical;Cognitive;cognitive task;Computer Models;Corpus striatum structure;cost;Cost Control;cost estimate;Cost Measures;Data;Decision Making;Diagnostic;Dissociation;Dorsal;Down-Regulation;Economics;Equipment and supply inventories;Exercise;Exposure to;Failure;Food;Future;Goals;Healthy Eating;Human;Impairment;improved;Individual;Intervention;Laboratories;Literature;Maps;Measures;Mediation;Mediator;Mental disorders;Methodology;Modeling;Motivation;neural;neural circuit;neural correlate;Neurocognitive;neuroimaging;neuromechanism;neurophysiology;Neurosecretory Systems;novel;Outcome;Participant;Patient Self-Report;Pattern;Physiological;Play;Population;preference;Prefrontal Cortex;Process;promote resilience;prospective;Psychological Stress;Psychopathology;psychosocial;Reporting;Resources;response;Rewards;Risk Factors;Role;Self Perception;Self-control as a personality trait;Shapes;smoking cessation;social;stem;Stimulus;Stress;Stress Tests;stressor;Testing;theories;Time;tool;Work

PROJECT_TITLE: Neural and affective mechanisms underlying prospective self-control costs

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]