NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Neurofibromatosis;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

PHR: PROJECT 3: PROJECT NARRATIVE Advances in genomics have uncovered molecular drivers of clinically relevant biological groups of meningiomas. Our studies will identify metabolic biomarkers that can be used to interrogate these molecular characteristics in a non-invasive manner. Clinical translation of our studies will provide physicians with much-needed tools for stratifying and monitoring meningioma patients.

PI_NAMEs: VISWANATH, PAVITHRA  (contact)

PROJECT_TERMS: Address;Adult;Alanine;Amino Acids;Biochemical;Biological;Biological Markers;biomarker identification;Biopsy;Brain Neoplasms;Cells;Characteristics;Choline;Clinic;Clinical;Clinical Research;clinical translation;Clinical Trials;clinically relevant;Data;drug development;Enzymes;epigenomics;Evaluation;Evolution;FOXM1 gene;genetic information;genomic signature;Genomics;Glucose;glucose metabolism;Glutamine;Goals;Health Care Costs;high risk;Image;imaging biomarker;Immune;improved;in vivo;in vivo imaging;Individual;individual patient;individualized medicine;innovation;Knowledge;Light;Link;Magnetic Resonance Spectroscopy;Malignant Neoplasms;meningioma;Metabolic;metabolic imaging;Metabolism;Modeling;Molecular;molecular imaging;Molecular Profiling;Monitor;Mus;Mutation;neuro-oncology;Neurofibromin 2;non-invasive imaging;novel therapeutics;Oncogenes;Oncogenic;Outcome;overexpression;Pathway interactions;Patients;Phospholipid Metabolism;Physicians;pre-clinical;precision medicine;Primary Brain Neoplasms;procedure cost;programs;Proliferating;Proteomics;Pyruvate;Quality of life;Recurrence;research and development;Risk;Signal Pathway;Stratification;Time;Tissue Sample;Tissues;tool;transcription factor;Translating;treatment planning;tumor;tumor heterogeneity;Tumor Suppressor Proteins;Tumor Tissue;tumor xenograft;Up-Regulation;Visualization;WNT Signaling Pathway

PROJECT_TITLE: Project 3: Preclinical metabolic imaging of molecular alterations of meningiomas


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT 4: PROJECT NARRATIVE Glioblastoma is the most common malignant primary brain tumor, whereas meningioma is the most common primary brain tumor. The proposed study will utilize hyperpolarized carbon-13 metabolic imaging to investigate these two most common brain tumors to assess early biomarkers of treatment response and to differentiate subgroups. The findings of this study will improve the management of patients with brain tumors.

PI_NAMEs: LI, YAN  (contact)

PROJECT_TERMS: Accounting;Address;Adult;aggressive therapy;Alanine;alpha ketoglutarate;anatomic imaging;Appearance;Atlases;Benign;Bicarbonates;Biological;Biological Markers;Brain Neoplasms;Carbon;chemotherapy;Classification;Clinical;clinical implementation;clinical practice;clinical translation;Data;Development;DNA Methylation;early detection biomarkers;early phase clinical trial;Evaluation;Evolution;Excision;experience;genomic signature;Genomics;Glioblastoma;Glioma;Goals;Heterogeneity;Histologic;Histopathology;Image;image guided;imaging probe;imaging study;Imaging Techniques;improved;Infrastructure;innovation;Magnetic Resonance Imaging;Malignant - descriptor;Malignant Neoplasms;Measures;meningioma;Metabolic;Metabolic dysfunction;metabolic imaging;Metabolic Pathway;Metabolism;Methods;Molecular;molecular marker;molecular subtypes;Monitor;Motivation;Multimodal Imaging;Mutation;Newly Diagnosed;Noise;non-invasive imaging;novel;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Outcome;Patient Care;Patient Schedules;Patients;Pharmaceutical Preparations;pharmacodynamic biomarker;Pharmacodynamics;Phase;Population;Positioning Attribute;preclinical study;Primary Brain Neoplasms;Production;prognostic;Progression-Free Survivals;Pyruvate;Radiation therapy;radiological imaging;recruit;Recurrence;regional difference;Research;Research Personnel;Resected;Resistance;Resolution;Resources;response;risk stratification;Scanning;Series;Signal Transduction;Subgroup;success;System;Techniques;Technology;Testing;Therapeutic;Therapeutic Agents;Time;Tissue Sample;Tissues;Tracer;Translating;treatment planning;treatment response;trial planning;tumor;Tumor Biology;tumor heterogeneity;uptake;Validation

PROJECT_TITLE: Project 4: Clinical translation and validation of metabolic probes to evaluate brain tumors

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-F (M1)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

PHR: BIOSPECIMEN AND BIOMARKER CORE: PROJECT NARRATIVE The Biospecimen and Biomarker Core, will provide expert staff and technology dedicated to the procurement, processing, distributing, and analysis of high-quality, spatially and regionally mapped brain tumor biospecimens. This will ensure rigorous and optimal biospecimen quality and maximize biospecimen use and data sharing to accelerate advances in translational brain tumor research.

PI_NAMEs: PHILLIPS, JOANNA  (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;advanced analytics;analytical method;Animal Model;Biological Assay;Biological Markers;Brain Mapping;Brain Neoplasms;cancer imaging;central database;Clinical;Clinical Services;Collaborations;Complement;Confidentiality of Patient Information;Data;data sharing;Databases;Dedications;Diagnosis;Ensure;Equipment and supply inventories;Evolution;experimental analysis;Foundations;genomic data;genomic signature;Genomics;Glioblastoma;Goals;Grant;Histologic;Human;Image;Image Analysis;image guided;improved;improved outcome;In Situ Hybridization;Informed Consent;Infrastructure;insight;Knowledge;Leadership;Link;Magnetic Resonance Imaging;meningioma;metabolic imaging;Methods;Molecular;Molecular Analysis;Molecular Profiling;neuropathology;Newly Diagnosed;novel;novel therapeutic intervention;Operating Rooms;Pathology;Patient-Focused Outcomes;Patients;preclinical imaging;preservation;Procedures;Process;Proteins;Recurrence;Regulation;Research;Research Project Grants;Resources;RNA;Sampling;Science;Standardization;Techniques;Technology;Testing;Time;Tissue Sample;Tissues;transcriptomics;tumor;tumor heterogeneity;tumor metabolism;Tumor Tissue;tumor xenograft;Variant;whole slide imaging

PROJECT_TITLE: Core B: Biospecimen and Biomarker Core (BSBM)


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Neurosciences;Precision Medicine;Rare Diseases

PHR: IMAGING TUMOR HETEROGENEITY & METABOLISM CORE: PROJECT NARRATIVE The Imaging Tumor Heterogeneity & Metabolism Core provides Projects of the P01 with the high degree of research and clinical imaging support by applying advanced imaging methods and novel data analysis procedures to facilitate the collection of image-guided tissue samples during surgical resection and providing metabolic and physiologic imaging correlates of gene expression that describe intra- and inter- tumor heterogeneity. Core functions will include the development of new methods and the translation and maintenance of technologies developed in the Projects from the prior and upcoming cycles into the clinic, creating the required framework to acquire, analyze, visualize, and interpret relationships between advanced metabolic and physiologic imaging features and underlying genomic drivers of intra- and inter-patient heterogeneity from spatially mapped tissue samples.

PI_NAMEs: LUPO, JANINE MARIE (contact)

PROJECT_TERMS: 3-Dimensional;Alanine;analysis pipeline;Animal Model;Biology;Brain Neoplasms;cancer imaging;Characteristics;Clinic;Clinical;clinical imaging;Clinical Management;clinical practice;clinical translation;Collection;Computer Analysis;Computer software;Data;data acquisition;Data Analyses;data standards;Databases;Development;Diagnosis;Dimensions;Epigenetic Process;Evolution;Excision;experience;experimental analysis;Foundations;Functional Imaging;Gene Expression;genomic signature;Genomics;Glioblastoma;Goals;Grant;Heterogeneity;Histologic;Histopathology;human error;Human Resources;Image;image guided;Imaging Device;imaging modality;Immunohistochemistry;improved;Individual;Infrastructure;Inter-tumoral heterogeneity;interest;Knowledge;Lesion;Location;Magnetic Resonance Imaging;Maintenance;Maps;meningioma;Metabolic;metabolic imaging;Metabolism;Methodology;Methods;Modeling;multidisciplinary;novel;Operative Surgical Procedures;Patient-Focused Outcomes;Patients;Phenotype;Physiologic pulse;Procedures;Process;Property;prospective;Protocols documentation;Pyruvate;Recurrence;Research;Research Personnel;Research Project Grants;Resources;Services;Technology;Testing;Time;tissue mapping;tissue processing;Tissue Sample;Tissues;tool;Translating;Translations;tumor;Tumor Biology;tumor heterogeneity;tumor metabolism;Update;Validation;Visualization

PROJECT_TITLE: Core C: Imaging Tumor Heterogeneity and Metabolism Core (ITHM)


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Treatment of the frequent indications for anticoagulation among adults with epilepsy is complicated by theoretical pharmacokinetics, as well as in vitro and animal data, that support interactions between widely-used enzyme- inducing antiepileptic drugs (EI-AEDs) and direct-acting oral anticoagulants (DOACs), which would be expected to lead to a reduction in the therapeutic effectiveness of DOACs and an elevated risk of thromboembolic events. However, this may not translate to real-world changes in thromboembolic event risk upon co-prescription of these drugs, and there is scant research on EI-AED/DOAC interactions in humans, with the small number of available studies having highly inconsistent findings, major methodological limitations that impede interpretability, and an overall lack of consideration of the potential role of higher-order drug interactions. Leveraging large-scale administrative claims data to evaluate a nationally representative population of adults with epilepsy in the real- world setting, the proposed research will assess the associations between thromboembolic events and EI-AED/DOAC interactions, as well as the contributions of concomitant medications via three-way drug interactions, in order: to provide vital foundations for prescribing decisions in the substantial proportion of epilepsy patients that require anticoagulation; to report observed three-way drug interactions signals associated with EI-AEDs and DOACs to drive further investigations; and, to advance potential approaches for higher-order drug interaction screenings using real-world data.

PI_NAMEs: ACTON, EMILY KATE (contact)

PROGRAM_OFFICER_NAME: HARTMAN, ADAM L

PROJECT_TERMS: absorption;active comparator;Address;Adult;Affect;animal data;Animal Experimentation;anti-epileptic agents;Anticoagulants;Anticoagulation;Atrial Fibrillation;Benchmarking;Biological;career;Carrier Proteins;Case Study;Clinical;clinical risk;cohort;comparative safety;comparison group;complex data;Crossover Design;CYP3A4 gene;Data;Data Set;Databases;deep vein;design;Disease;Drug Interactions;Drug Kinetics;Drug Prescriptions;Enzyme Induction;Enzyme Interaction;Enzymes;Epilepsy;Event;experience;experimental study;Exposure to;Failure;Foundations;Future;Glycoproteins;Goals;Graph;health care service utilization;Hemorrhage;high dimensionality;High Prevalence;high risk;Human;improved;In Vitro;Incidence;Individual;Intestinal Absorption;Investigation;Kidney;Knowledge;Link;Medical;Mentors;Metabolism;Methodology;Methods;Nature;Nervous System Disorder;Neuroepidemiology;novel;Observational Study;Oral;Outcome;Patients;Permeability;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;Polypharmacy;Population;Postdoctoral Fellow;Practice Guidelines;Prevalence;Proxy;Pulmonary Embolism;Reporting;Research;Research Personnel;Risk;Role;screening;Series;Signal Transduction;skills;Therapeutic;therapeutic effectiveness;thrombotic;Thrombus;Training

PROJECT_TITLE: Interactions of Enzyme-Inducing Antiepileptic Drugs with Direct-Acting Oral Anticoagulants: Risk of Thromboembolic Events

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-D(20)L]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: MADISON

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE This project is directed towards the development of powerful new bioanalytical research tools for identifying and quantifying biological macromolecules. These tools, which will be made widely available to all researchers, will reveal new information essential to the understanding of both normal and disease biology, deepening and accelerating the study of human disease processes.

PI_NAMEs: SMITH, LLOYD M (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Acceleration;Algorithms;Amino Acid Sequence;Atlases;Bioinformatics;Biological;Biological Process;biological systems;Biology;Cell Physiology;Cells;Complex;complex biological systems;Complex Mixtures;Computer software;Data;data acquisition;Data Analyses;Databases;Development;Dimensions;Disease;Dissociation;Effector Cell;Enzymes;field study;Genome;Human;human disease;Individual;infancy;informatics tool;interest;Ions;Laboratories;macromolecule;Manuals;Measurement;Methods;model organism;Molecular;novel strategies;Pathway interactions;Post Translational Modification Analysis;Post-Translational Protein Processing;Process;Proteomics;Quantitative Trait Loci;Research;Research Personnel;Resolution;response;Sampling;Scientist;Source;System;Systems Biology;Technology;Time;tool;transcriptome sequencing;Validation;Visualization software;Work

PROJECT_TITLE: Revealing Proteoforms: The Primary Effectors of Biological Function

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: DURHAM

ORG_DEPT: SURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE SLC25A4 deficiency is an inherited disorder that manifests as a progressive skeletal myopathy and hypertrophic cardiomyopathy; there are no effective systemic therapies for affected patients. Preliminary data from our laboratory demonstrate that recombinant AAV vectors with specific tropism for skeletal muscle cells and cardiomyocytes can be synthesized. Here, we investigate the efficacy of myotropic AAV-mediated gene replacement as a therapeutic option for SLC25A4 deficiency.

PI_NAMEs: BENKERT, ABIGAIL  (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Adrenergic Agents;Affect;autosome;Base Pairing;Biochemical;Cardiac Myocytes;Cardiomyopathies;career;Cell Line;Cell model;Cells;Codon Nucleotides;cohort;Complementary DNA;Data;delivery vehicle;Development;Disease;disease phenotype;Disease Progression;DNA;efficacy evaluation;Evaluation;Exertion;experimental study;Family;Fellowship;Foundations;Frameshift Mutation;Functional disorder;gene replacement;gene replacement therapy;Generations;genetic pedigree;Goals;Heart failure;Heart Transplantation;Hereditary Disease;human induced pluripotent stem cells;Hypertrophic Cardiomyopathy;Impairment;improved;In Vitro;in vitro Model;Individual;Inherited;Inner mitochondrial membrane;Laboratories;Lactic Acidosis;Link;loss of function;Mediating;member;Mendelian disorder;Mennonite;Mitochondria;mitochondrial metabolism;Mitochondrial Proteins;Modality;Modeling;Modification;Molecular;Muscle Cells;Muscle Fibers;Mutation;Myocardial;Myocardial dysfunction;Myocardium;Myopathy;Natural History;next generation;Nuclear;null mutation;Organ;Organoids;Oxidative Phosphorylation;patient derived induced pluripotent stem cells;Patients;Phenotype;Pre-Clinical Model;premature;prevent;Protein Isoforms;Proteins;Recombinants;Recovery;reduce symptoms;Research;Research Personnel;restoration;Scientist;Secondary to;skeletal;Skeletal Development;Skeletal Muscle;skills;SLC25A4 gene;solute;Structure;Surgeon;Systemic Therapy;Therapeutic;therapeutic gene;Tissues;Training;Transgenes;Translating;Translational Research;Translations;treatment strategy;Tropism;vector;vector biodistribution;Viral;Viral Vector

PROJECT_TITLE: Evaluation of adeno-associated viral (AAV) mediated gene replacement therapy as a therapeutic option for SLC25A4 deficiency


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Proteoforms, the diverse molecular entities that comprise a protein, can have myriad biological functions and roles in disease. The most powerful method for proteoform measurement is mass spectrometry, but proteoform measurement using this instrument tends to be slow and difficult. We aim to develop technologies to enable rapid and simpler proteoform measurement by mass spectrometry for the purpose of enabling more biomedical research into proteoform function in biology and human disease.

PI_NAMEs: MANICKE, NICHOLAS E (contact)

PROJECT_TERMS: accurate diagnostics;Affinity;Antibodies;Biological;Biological Process;Biology;Biomedical Research;Cell Culture Techniques;chemical property;Chemicals;Chemistry;Complex;cost;Coupled;Crowding;design;Detection;detection limit;Development;Devices;Diagnostic;Diagnostic tests;Digestion;Disadvantaged;Disease;Disease Marker;disease prognostic;Disease Progression;DNA Sequence Alteration;Electrophoresis;Electrospray Ionization;Engineering;exome sequencing;experimental study;frontier;Goals;high throughput analysis;Human Biology;human disease;human genome sequencing;Immobilization;Immobilized Enzymes;improved;Indiana;instrument;ionization;Ions;Liquid substance;mass spectrometer;Mass Spectrum Analysis;Measurement;Measures;Membrane;metabolomics;Methods;Molecular;Neurofibromin 2;novel strategies;Paper;Parents;Pepsin A;Peptide Hydrolases;Peptides;Performance;physical property;Porosity;portability;Post-Translational Protein Processing;Process;Protein Analysis;protein purification;Proteins;Proteome;Pump;Research;Research Personnel;Resolution;RNA Splicing;Role;Sampling;scale up;Scientist;Serum;Single Nucleotide Polymorphism;Specialist;specific biomarkers;Specificity;Speed;System;tandem mass spectrometry;targeted treatment;Technology;Time;tool;Trypsin;Universities;Variant;Western Blotting;Work

PROJECT_TITLE: Combining Separation, Digestion, and Ionization on a Mass Spectrometry Cartridge to Enable Biomedical Research on Proteoforms

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Machine Learning and Artificial Intelligence

ORG_CITY: SEATTLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE This research seeks to develop predictive and cell type-specific models of alternative splicing by learning from millions of synthetic splicing constructs, characterized across a large number of cell types. Models will be combined with molecular design algorithms to engineer splicing constructs that target protein production to cells of interest thus providing a path toward increasing the specificity of future gene therapies.

PI_NAMEs: SEELIG, GEORG  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Algorithm Design;Alternative Splicing;Animals;Biological Assay;biological systems;Biology;Brain;cancer cell;Cell Line;cell type;Cells;Code;convolutional neural network;Data;design;Development;Disease;disease diagnosis;Engineering;exon skipping;Future;Gene Expression;gene therapy;generative models;Genes;Genetic;High-Throughput Nucleotide Sequencing;Human Cell Line;improved;insight;interest;Introns;Learning;Libraries;Machine Learning;machine learning model;Maps;Measures;Modeling;Molecular;Mouse Cell Line;Mutation;network architecture;Neurobiology;novel;novel strategies;predictive modeling;Primary Cell Cultures;Production;protein expression;Protein Isoforms;Proteins;Rat Cell Line;Rattus;Reading;recurrent neural network;Regulation;Regulatory Element;Reporter;Reporter Genes;Research;RNA Splicing;RNA-Binding Proteins;Role;side effect;single cell analysis;single-cell RNA sequencing;Slice;Specificity;synthetic biology;System;Testing;therapeutic gene;Tissues;tool;Training;training data;transcriptome;Variant;Work

PROJECT_TITLE: Engineering cell type-specific splicing regulation

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Aging;Burden of Illness;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE Colorectal cancer (CRC) is the third most common cancer and the third leading cause of cancer death, but it affects some racial and ethnic groups more than others. Our proposed research will summarize current knowledge about racial/ethnic disparities in CRC screening, treatment, and outcomes, and will use this information to estimate the extent to which disparities in care explain disparities in CRC outcomes, and to evaluate policies to reduce disparities.

PI_NAMEs: RUTTER, CAROLYN M (contact)

PROGRAM_OFFICER_NAME: WHITE, DOLLY PENN

PROJECT_TERMS: Accounting;Address;Affect;Age;Alaska Native;Algorithms;American;American Indians;Asian;Awareness;Bayesian Analysis;Black American;black patient;Black Populations;Black race;Calibration;cancer care;Cancer Etiology;cancer health disparity;care costs;care outcomes;Caring;Case Study;caucasian American;Cessation of life;Characteristics;Clinical;Collaborations;colon cancer patients;Colonoscopy;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;colorectal cancer screening;colorectal cancer treatment;Complex;Continuity of Patient Care;cost;Costs and Benefits;curative treatments;Data;Decision Making;design;Diagnosis;Disadvantaged;Disease;Disparity;disparity reduction;Early Diagnosis;economic outcome;Economics;electronic health system;Elements;Equity;ethnic difference;ethnic disparity;Ethnic Origin;Ethnic Population;experience;Feces;Financial cost;follow-up;Future;Goals;Guidelines;Health;Health Care Costs;health care disparity;Health Policy;Healthcare;Hispanic;Human;improved;Incidence;Income;Individual;information gathering;innovation;insight;Institutional Racism;Insurance;Insurance Coverage;Intervention;Knowledge;Life;Malignant Neoplasms;Measures;Mediating;member;Methods;model development;Modeling;models and simulation;mortality;multidisciplinary;Natural History;Not Hispanic or Latino;Outcome;outcome disparities;outreach;Pacific Islander;patient population;Patients;Persons;Policies;Polypectomy;Population;Process;Qualifying;Quality-Adjusted Life Years;Race;racial difference;racial disparity;racial population;Recommendation;Records;Research;Review Literature;Risk;Rural;screening;simulation;societal costs;Stage at Diagnosis;statistics;success;Testing;Treatment Cost;trend;Uncertainty;Update;uptake;urban residence;Variant;Work;years of life lost

PROJECT_TITLE: Health and Financial Costs of Unequal Care: Colorectal Cancer as a Case Study

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

PHR: PROJECT NARRATIVE  The proposed research is relevant to public health because it will investigate a novel method of reducing the impact of implicit bias on therapeutic relationships, healthcare delivery, and consequent patient health outcomes. This could have a revolutionary impact on reducing bias in healthcare delivery and resulting health disparities nationwide. This project directly responds to recommendations from several institutes and research groups who have identified reduction of implicit bias in healthcare and resulting health disparities as a matter of extreme importance and urgency, including the National Institute of Health (NIH), the Agency for Healthcare Research and Quality (AHRQ), and the Center for Disease Control (CDC).

PI_NAMEs: JAMES, LOIS  (contact)

PROJECT_TERMS: addiction;Address;Affect;African American population;Analgesics;Attitude;Awareness;Belief;Care given by nurses;care outcomes;Centers for Disease Control and Prevention (U.S.);Cessation of life;Client satisfaction;college;Communication;Complex;Conscious;Control Groups;Decision Making;design;Development;disability;Discipline of Nursing;Disparity;economic impact;Effectiveness;effectiveness testing;Ethnic Origin;experience;explicit bias;Gender;healing;Health;health care delivery;health care disparity;health disparity;Health Professional;Healthcare;Homelessness;Hospitals;Hour;Human;Implicit Association Test;implicit bias;Inequality;Inequity;innovation;Intervention;Learning;lectures;Lesbian Gay Bisexual Transgender Queer;Manikins;Measures;Medical center;medication administration;member;Methods;Military Personnel;minority health disparity;minority healthcare;novel;novel strategies;Nurses;Outcome;Patient Care;Patients;Performance;Persons;Pharmaceutical Preparations;Police;Police officer;post intervention;Prejudice;programs;Public Health;Questionnaires;Race;racial bias;Randomized, Controlled Trials;Recommendation;Research;Review Literature;simulation;skills;social group;Social Justice;Socioeconomic Status;Testing;Therapeutic;Training;Training Programs;treatment group;unconscious bias;Unconscious State;United States Agency for Healthcare Research and Quality;United States National Institutes of Health;Universities;virtual experiments;Washington

PROJECT_TITLE: Counter Bias Training Simulation (CBTsim) Healthcare: A Novel Approach for Reducing the Impact of Implicit Bias on Healthcare Delivery


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cancer;Dementia;Genetics;Neurodegenerative;Neurosciences;Parkinson's Disease;Skin Cancer

ORG_CITY: PORTLAND

ORG_DEPT: NEUROLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Parkinson’s Disease and melanoma are two diseases of aging that show a positive epidemiological association. Both characterized by genomic instability, the role of alpha-synuclein in nucleolar DNA double-strand break repair could hold a molecular connection between these two diseases. This proposal aims to determine the role of alpha-synuclein in nucleolar DNA double-strand break repair and melanoma growth and metastasis through cellular senescence modulation.

PI_NAMEs: ARNOLD, MORIAH REBECCA (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Affect;Age;Aging;aging related disease;alpha synuclein;Alzheimer's Disease;Animals;Antibodies;Binding;Biogenesis;Biological Assay;Biotinylation;Brain;Breeding;Cell Aging;cell growth;Cell Line;Cell Nucleolus;Cell Nucleus;Cell Proliferation;Cell Survival;Cells;Central Nervous System;Clinical;Complex;Cutaneous Melanoma;Cytoplasmic Inclusion;Data;Development;Diagnosis;Disease;disorder risk;DNA;DNA Double Strand Break;DNA Repair;Double Strand Break Repair;Electron Microscopy;endonuclease;Environmental Risk Factor;Epidemiology;epidemiology study;Eukaryotic Cell;gain of function;Genes;genetic risk factor;Genetic Transcription;Genome Stability;Genomic Instability;Goals;Growth;Histologic;Human;Human Cell Line;Image;Immunofluorescence Microscopy;Impairment;In Vitro;in vivo;Incidence;Individual;insight;Invaded;Knock-out;Knockout Mice;Label;Lewy Bodies;Lewy Body Dementia;Lewy Body Disease;Link;loss of function;Malignant Neoplasms;Measures;Melanogenesis;Melanoma;Melanoma Cell;Melanoma patient;Melanoma Tumor;melanomagenesis;Metastatic Melanoma;Metastatic Neoplasm to Lymph Nodes;Methodology;Methods;Modeling;Molecular;mouse model;Movement;Mus;mutant;Mutate;Mutation;Neoplasm Metastasis;Nerve Degeneration;Neurodegenerative Disorders;Neurons;new therapeutic target;novel;Nuclear;overexpression;Parkinson Disease;Pathologic;Pathway interactions;Patients;Persons;Phenotype;Play;Presynaptic Terminals;Primary Neoplasm;Proteomics;Publishing;Regulation;repair function;repaired;Ribosomal DNA;Ribosomes;Risk;Role;senescence;Skin Cancer;SNCAIP gene;Substantia nigra structure;Techniques;Testing;Tissues;tumor growth;Up-Regulation;Variant;Work

PROJECT_TITLE: The role of alpha-synuclein in nucleolar DNA double-strand break repair and cellular senescence


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Biomedical scientists use descriptions of biomedical concepts (and of the relationships among concepts) known as ontologies to standardize how researchers and clinicians talk about biomedical phenomena. There are hundreds of such ontologies covering different areas of biomedicine, and finding, accessing, and putting ontologies to use can be extremely challenging. BioPortal provides a knowledgebase that integrates more than 800 biomedical ontologies, making it easy for scientists and clinicians to use the resulting knowledge to describe their data, to access information more reliably, to build other knowledge resources in standardized ways, and to bring biomedical knowledge both to the laboratory and to the point of care.

PI_NAMEs: MUSEN, MARK A (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Academia;Access to Information;Adopted;Adoption;Area;Biological Sciences;biomedical ontology;biomedical scientist;Businesses;Collection;Communities;community engagement;computer infrastructure;Data;data integration;Discipline;Environmental Science;Government;Graph;Growth;Healthcare;improved;Industry;Information Management;Information Resources;Infrastructure;Knowledge;knowledge graph;knowledge integration;Knowledge Management;knowledge of results;knowledgebase;Laboratories;Link;Medical;Mission;Monitor;natural language;Natural Language Processing;Ontology;Paper;phrases;point of care;programs;Recording of previous events;repository;Research Personnel;Resources;Running;Science;Scientist;Semantics;Services;Source;Standardization;Suggestion;System;systems research;Technology;Text;Time;United States National Institutes of Health;web server;web services;Work

PROJECT_TITLE: BioPortal: An Expansive Knowledgebase of Biomedical Entities and Relations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T(55)R]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular

ORG_CITY: MILWAUKEE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: PROJECT NARRATIVE Cardiovascular disease (CVD) remains the leading cause of death in the United States, with atherosclerosis being a major cause of CVD. Our research is designed to study FFAR4, a novel protein that protects against lipid accumulation in macrophages (or foam cell formation), the hallmark of atherosclerosis. The outcomes of these proposed studies will uncover the underlying mechanisms that drive FFAR4’s cardio-protective properties, and may ultimately identify FFAR4 as a novel therapeutic target for atherosclerosis.

PI_NAMEs: STUTTGEN, GAGE M (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Adipocytes;Agonist;Anti-Inflammatory Agents;Aorta;Area;Arterial Fatty Streak;Arteries;atheroprotective;Atherosclerosis;ATP binding cassette transporter 1;Attention;Biological Process;Blood specimen;Bone Marrow Transplantation;cardioprotection;Cardiovascular Diseases;Cause of Death;CD36 gene;Cell Nucleus;Cholesterol;cholesterol transporters;cytokine;Cytoplasm;Data;design;Development;Diabetes Mellitus;Disease;Endothelial Cells;Experimental Designs;experimental study;Fasting;Foam Cells;Future;G-Protein-Coupled Receptors;Harvest;Homeostasis;Image;immune activation;in vivo;Incubated;Infiltration;Inflammation;Inflammatory;Inflammatory Response;insulin sensitivity;Knockout Mice;lipid biosynthesis;Lipids;Literature;Low Density Lipoprotein Receptor;Macrophage;Measures;Mediating;Metabolic;migration;Mus;new therapeutic target;Nonesterified Fatty Acids;novel;obesity prevention;Outcome;oxidized low density lipoprotein;Pathway interactions;Peritoneal Macrophages;Phosphorylation;Physiological;Play;prevent;Prevention;Process;Property;Proteins;Publishing;receptor;Research;Role;Severities;Signal Pathway;Signal Transduction;Testing;therapeutic target;transcription factor;United States;Unsaturated Fatty Acids;uptake;western diet;Wild Type Mouse

PROJECT_TITLE: Investigating the Novel Roles of FFAR4 in Foam Cell Formation and Atherosclerosis


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Contraception/Reproduction;Maternal Health;Pediatric;Pregnancy;Women's Health Research

ORG_CITY: Chicago

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE Invading extravillous trophoblasts (EVTs) are specialized cells of the placenta that directly contact maternal decidual immune cells and play a critical role in vascular remodeling at the onset of pregnancy. These cells expressed an enigmatic molecule called HLA-F; our study is designed to provide a better understanding of HLA-F molecules and their interactions with receptors on decidual natural killer cells. Given that inadequate tolerance of EVTs by decidual immune cells can lead to miscarriages and other pregnancy disorders, the results of our study on HLA-F have implications for our understanding of these pathologies and treatments.

PI_NAMEs: BOUVIER, MARLENE  (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Address;Aminopeptidase;Binding;Biochemical;Biological Assay;biophysical techniques;Blood;Cell Shape;cell type;Cells;Communication;Complex;conformer;Decidua;design;early pregnancy;Endometrium;Ensure;Family;fetal;Fetus;fetus cell;First Pregnancy Trimester;healthy pregnancy;HLA-A gene;HLA-B Antigens;HLA-C Antigens;Immune;Immune Tolerance;Immunobiology;Immunoglobulins;Immunologics;immunoregulation;implantation;In Vitro;Infant Mortality;Invaded;Investigation;killer inhibitory receptor;KIR3DS1;Knowledge;Length;Leukocytes;Major Histocompatibility Complex;Mass Spectrum Analysis;Maternal-Fetal Exchange;Maternally-Acquired Immunity;migration;Molecular;Natural Killer Cells;NK cell receptor NKB1;Pathology;Peptides;Physiological Processes;Placenta;Play;Population;Pregnancy;Pregnancy Complications;pregnancy disorder;Property;receptor;Receptor Cell;Risk;Role;Scheme;Spiral Artery of the Endometrium;Spontaneous abortion;Surface;Tissues;trophoblast;tumor-immune system interactions;Uterus;Vascular remodeling;Villous;Work;X-Ray Crystallography

PROJECT_TITLE: HLA-F in maternal-fetal immune crosstalks

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Asthma;Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Lung;Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Respiratory viruses cause strong activation of sensory C-fibers, which in turn causes sneezing, coughing, and secretions. It is also likely that the activation of C-fibers contributes to reflex bronchoconstriction in children with asthma and the exacerbation of their disease. Since little is known about the mechanisms by which respiratory viruses lead to C-fiber activation, we will address the hypothesis that, with regard to coronaviruses, activation is partially mediated by direct interaction between the viral spike proteins and C-fiber terminals in the airway mucosa.

PI_NAMEs: KIM, JOYCE SOOYEON (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: 2019-nCoV;ACE2;Action Potentials;activated Protein C;Address;afferent nerve;Affinity;Alveolus;Angiotensin Receptor;Asthma;asthma exacerbation;betacoronavirus;Binding;Bronchi;Bronchoconstriction;C Fiber;Cell membrane;Cells;Child;Chronic;Chronic Obstructive Pulmonary Disease;Common Cold;Communities;Coronavirus;Coronavirus spike protein;Coughing;COVID-19 pandemic;Data;Disease;Electrophysiology (science);Embryo;Epithelial Cells;extracellular;Fellowship;Functional disorder;Goals;human disease;Imaging Techniques;Individual;Infection;insight;Ion Channel;Lead;Lung;Mediating;Mediator;Membrane;Membrane Glycoproteins;Middle East Respiratory Syndrome Coronavirus;Molecular;mRNA Expression;Mus;Nerve;Nervous System;Neural Crest;Neurons;Nociception;Nociceptors;Nodose Ganglion;Nose;novel;Oropharyngeal;patch clamp;Phenotype;Process;Production;Protein Subunits;Proteins;receptor;Reflex action;Research Proposals;respiratory;Respiratory Disease;Respiratory Mucosa;Respiratory System;Respiratory Tract Infections;respiratory virus;Reverse Transcriptase Polymerase Chain Reaction;SARS coronavirus;SARS-CoV-2 spike protein;Secondary to;Sensory;Sneezing;Sore Throat;Spinal;Spinal Ganglia;Stimulus;Surface;Symptoms;theories;TLR4 gene;Toll-like receptors;Trachea;transmission process;TRPA channel;TRPV1 gene;two-photon;Viral;virtual;Virus;Virus Diseases;virus morphology

PROJECT_TITLE: Vagal airway sensory nerve activation by beta-coronavirus spike protein


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Suicide Prevention;Violence Against Women;Violence Research;Women's Health Research

PHR: PROJECT NARRATIVE This proposed study addresses aligns with NIMHD’s Research’s Strategic Plan, which highlights the crucial need to take life course and multi-level approaches to advance the science of minority health disparities through dissemination and implementation of novel scientific and community-driven approaches. Social determinants of health contribute to the disparate impact of migration-related trauma and suicide on Latina immigrants, and this innovative study will further inform our understanding of cultural resilience by exploring salient communal and cultural factors that have been less explored in this population. With an enhanced understanding of how migration-related trauma influences mental health symptom severity and risk of suicide in the context of salient cultural and communal resources, we will be better positioned to develop targeted trauma-informed, suicide- prevention interventions to promote health equity and the psychological wellbeing of Latina immigrants.

PI_NAMEs: MATA LOPEZ, LAURA REBECA (contact)

PROGRAM_OFFICER_NAME: GARRIDO, CARLOS OSWALDO

PROJECT_TERMS: Address;Adopted;Adult;aged;Anxiety;Area;Baltimore;Cause of Death;Cessation of life;Chronic;Chronic Disease;Chronic stress;Collaborations;commune;Communities;community advisory board;community based participatory research;community collaboration;community engagement;community partners;Complex;Conflict (Psychology);coping;Country;Cross-Sectional Studies;deprivation;Development;Discipline of Nursing;Disease Management;Disparity;Dissemination and Implementation;Documentation;Economics;experience;Exposure to;Face;Family member;Feedback;Feeling suicidal;Focus Groups;Funding;Future;Gender;Growth;healing;Health;health equity promotion;Immigrant;Immigrant community;Individual;innovation;International;Interview;Kidnappings;Knowledge;Language;Latin America;Latina;Latina Population;Latino;Legal;Length;Life Cycle Stages;Literature;Lived experience;member;Mental Depression;Mental Health;Mentorship;Methods;metropolitan;migration;minority health;minority health disparity;National Institute on Minority Health and Health Disparities;Natural Disasters;novel;Nurses;Outcome;outcome disparities;Pattern;Personal Satisfaction;Politics;poor health outcome;Population;Positioning Attribute;Post-Traumatic Stress Disorders;pre-doctoral;preventive intervention;promote resilience;protective factors;Provider;psychological distress;psychosocial;racism;Religiosity;Research;Research Personnel;resilience;resilience factor;Resources;Review Literature;Risk;Risk Factors;Ritual compulsion;Science;Self Efficacy;Severities;sexual assault;Shapes;social determinants;social health determinants;Social isolation;social stressor;Social support;Spirituality;Strategic Planning;Stress;suicidal risk;Suicide;Suicide attempt;Suicide prevention;Survey Methodology;Symptoms;systematic review;Time;Trauma;trauma exposure;United States;United States National Institutes of Health;Violence;Well in self;Woman;Work

PROJECT_TITLE: Hardship and Survival: The Impact of Migration-Related Trauma, Communal Coping, and Social Stressors on the Suicide and Mental Health Outcomes of Latina Immigrant Women

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: PROJECT NARRATIVE Human induced pluripotent stem cells (hiPSCs) have tremendous potential in the development of preclinical heart models but are limited in their clinical relevance due to low, inconsistent, and heterogeneous cardiomyocyte (CM) yield after differentiation. The proposed work will investigate how different hiPSC clonal lineages respond to differentiation cues, characterize lineages based on affinity for becoming CMs, and target low-affinity lineages with additional differentiation cues to increase quantity, consistency, and homogeneity of CM yield. This will elucidate mechanisms affecting hiPSC cardiac differentiation and generate methods for producing hiPSC- derived CMs on a clinically relevant scale.

PI_NAMEs: SOHN, SOGU  (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Accounting;Address;Adult;Affect;Affinity;Bar Codes;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Categories;Cause of Death;Cell Lineage;cell type;Cells;clinical translation;clinically relevant;cost;Cues;Data;Disease;disease model;Frequencies;Gene Expression;Gene Expression Profile;Genes;Genetic;Goals;Guide RNA;Heart;Heart Atrium;heart function;Heritability;Heterogeneity;Human;human induced pluripotent stem cells;improved;induced pluripotent stem cell derived cardiomyocytes;Label;Libraries;Measures;Methods;Modeling;Monitor;next generation sequencing;Outcome;Pacemakers;Pathway interactions;Patients;pluripotency;pluripotent stem cell differentiation;Population;Population Heterogeneity;Pre-Clinical Model;preclinical development;Predisposition;Procedures;Process;Production;Public Health;Research;response;Risk;small molecule;Somatic Cell;Source;Specific qualifier value;stem cell function;Stem cell pluripotency;stem cell population;Stem Cell Research;Stimulus;Teratoma;Testing;theories;Time;Tissue Model;tool;transcriptome;transcriptomics;tumor;United States;Ventricular;Work

PROJECT_TITLE: Elucidation and improved control of human induced pluripotent stem cell cardiac differentiation by using single-guide RNA-based cellular barcoding to track and manipulate lineages

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric

PHR: PROJECT NARRATIVE  Chromatin regulators are disproportionately mutated in individuals with neurodevelopmental disorders. Dot1L, a methyltransferase, is one such protein in which patients with monoallelic de novo mutations solely in Dot1L have deficits such as global developmental delay. This proposal aims to examine Dot1L’s contribution to transcriptional regulation in the brain and Dot1L’s impact on neuronal function and behavior with hopes to provide insights into a broader understanding of chromatin regulators role in brain function and neurodevelopmental disorders.

PI_NAMEs: MARONI, MARISSA  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Address;Affect;AMPA Receptors;autism spectrum disorder;Behavior;behavior test;Behavioral;Brain;causal variant;Cell Nucleus;cell type;Cells;Cerebellum;Child;Chromatin;Cognition;conditional knockout;Coupled;Data;de novo mutation;Deposition;Development;Developmental Delay Disorders;DNA;Electrophysiology (science);epigenetic regulation;exome sequencing;experimental study;Gene Expression;Genes;Genetic Transcription;Genomic Segment;global developmental delay;Heterozygote;Hippocampus;histone methylation;histone methyltransferase;Histone-Lysine N-Methyltransferase;Histones;Individual;insight;Intellectual functioning disability;knock-down;Knockout Mice;Label;Language Development;Lead;long term memory;loss of function;loss of function mutation;Loss of Heterozygosity;Lysine;Measures;Memory impairment;Methylation;Methyltransferase;Modeling;mouse model;Mutate;Mutation;nerve stem cell;Neurodevelopmental Disorder;neuron development;Neurons;object recognition;old mice;Output;patch clamp;Patients;Phenotype;Play;Post-Translational Protein Processing;postmitotic;Prosencephalon;Protein Analysis;protein function;Proteins;receptor;Regulation;Reversal Learning;Role;Running;stem cell proliferation;Synapses;Synaptic Receptors;Time;Tissues;Transcriptional Regulation;transcriptome sequencing;Ultrasonics;vocalization;Western Blotting;Work;wound

PROJECT_TITLE: The Role of H3K79 Methylation and Dot1L in Neuronal Function and Neurodevelopmental Disorders


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Precision Medicine;Prevention;Social Determinants of Health

ORG_CITY: Prairie View

ORG_DEPT: BIOLOGY

ORG_NAME: PRAIRIE VIEW AGRI & MECH UNIVERSITY

PHR: Public Health Relevance Section Prairie View A&M University (PVAMU) will partner with the Children’s Nutritional Research Center at the Baylor College of Medicine to create a T32 training program to train Ph.D. students and post- doctoral fellows to study precision nutrition research with AI and machine learning skills. The training program at PVAMU, can prepare the future practitioners in precision nutrition research.

PI_NAMEs: ANTWI, JANET ;KIM, SEUNGCHAN  (contact);MUSAAD, SALMA

PROGRAM_OFFICER_NAME: BICKHAM-WRIGHT, UTIBE RONALD

PROJECT_TERMS: Future;health equity;nutrition;Nutritional Study;precision nutrition;Underserved Population

PROJECT_TITLE: Increasing and Diversifying Future AI-Precision Nutrition Research Workforce to Promote Nutrition Health Equity among Underserved Populations


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: ANN ARBOR

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Normal-tension glaucoma (NTG) is characterized by the progressive degeneration of the optic nerve in patients who have an intraocular pressure within the normal range. Understanding the molecular mechanisms of pathogenesis for this disorder may improve the early screening and treatment options available to patients.

PI_NAMEs: PRESLEY, WILLIAM THOMAS (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: 12q13;Adult;Affect;ATP phosphohydrolase;autosome;biobank;Biological Assay;Blindness;Blood;Blood specimen;Candidate Disease Gene;career;Cells;Chromosomes;Classification;Co-Immunoprecipitations;Code;cohort;Coupling;Data;Databases;Defect;Diagnosis;Disease;Disease Progression;early screening;Early treatment;Electrostatics;Escherichia coli;exome;experimental study;Extracellular Matrix;Extracellular Matrix Proteins;Family;Family member;Functional disorder;Future;gene discovery;Gene Expression;Gene Expression Profiling;gene function;Gene Mutation;Genes;Genetic;Genetic Diseases;genetic pedigree;genetic variant;genome analysis;genome sequencing;genome wide association study;Genomics;Glaucoma;Goals;Heat-Shock Proteins 90;Heritability;human disease;Impairment;improved;in silico;In Vitro;Individual;Link;Maintenance;member;Mendelian disorder;Methods;Missense Mutation;Modeling;modifiable risk;Molecular;Molecular Chaperones;molecular diagnostics;mutant;Mutation;N-terminal;Normal Range;novel;novel therapeutics;Nucleotides;Optic Atrophy;Optic Nerve;optic nerve disorder;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Physiologic Intraocular Pressure;Population;Positioning Attribute;Prevalence;Production;protein protein interaction;Proteins;rare variant;Recording of previous events;Regulation;retinal ganglion cell degeneration;Risk;Risk Factors;risk variant;RNA Polymerase II;Role;Running;scaffold;Scaffolding Protein;Scientist;screening;segregation;skills;Structure;Tertiary Protein Structure;Testing;Therapeutic;Tissue-Specific Gene Expression;traditional therapy;transcriptome sequencing;Variant;whole genome

PROJECT_TITLE: Validating novel candidate genes for normal-tension glaucoma


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Black people with disabilities disproportionately experience poor physical and behavioral health outcomes due to compounding socioeconomic challenges and stigma-related stressors. Intersectionality theory suggests that such magnified health inequities may be in part driven by experiences shaped by both racism and ableism, though few quantitative measures exist to capture this dynamic, multifaceted construct as it fluctuates over time and across contexts. To address this empirical gap, the proposed project will develop and validate a brief self-report measure of daily intersectional stigma experiences for Black people with disabilities via a three- phase, multimethod approach, with the goal of facilitating future observational and intervention research geared towards addressing the deleterious impact of intersectional stigma on this multiply marginalized population.

PI_NAMEs: WANG, PENG  (contact)

PROGRAM_OFFICER_NAME: GILLMAN, ARIELLE SAMANTHA

PROJECT_TERMS: ableism;Address;African American population;Age;Anxiety;behavioral health;Black Populations;Black race;Cardiovascular Diseases;Characteristics;Chronic;cognitive interview;cognitive process;Communities;cultural competence;Diabetes Mellitus;diaries;disability;Disability status;Disabled Persons;Discrimination;Disparity;Domestic Violence;emotion regulation;Empirical Research;Event;experience;Feedback;Fostering;Functional impairment;Future;Gender;Goals;Health;health care availability;health disparity populations;Health equity research;health inequalities;help-seeking behavior;improved;insight;intersectionality;Intervention Studies;Interview;Literature;Lived experience;marginalization;marginalized population;Measurement;Measures;Mediating;Mediator;Medical;member;Mental Depression;Mental Health;Methods;minority health;minority health disparity;Minority Health Research;Mission;National Institute on Minority Health and Health Disparities;novel;Observational Study;Outcome;Participant;Patient Self-Report;Perception;Persons;Phase;physical conditioning;physical inactivity;Pilot Projects;pilot test;poor health outcome;Population;Poverty;Prevalence;Probability;prospective;psychological distress;Psychometrics;psychosocial;psychosocial outcome;psychosocial stressors;Race;racism;recruit;Reporting;Research;Research Design;response;Risk Behaviors;Sampling;Services;sexual minority group;Shapes;Smoking;social;social determinants;Social Processes;social stigma;Social support;Socioeconomic Status;socioeconomics;Source;stressor;Structure;Testing;theories;Time;tool;Transportation;women of color;Work

PROJECT_TITLE: Developing and validating a quantitative measure of daily intersectional stigma experiences for Black people with disabilities

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because cell division is a fundamental process of broad importance, yet the mechanisms underlying how cells grow and elongate in highly confining microenvironments for cell division are unclear. Therefore, the proposed research on understanding of the force-based mechanisms of cell division in highly confining microenvironments, via combined experimental and computational approaches, is relevant to part of NIH’s mission that seeks to develop fundamental knowledge that will help reduce the burdens of human disability and disease. Ultimately, it is anticipated that this study will uncover new insights and provide a new perspective on cell division, which will contribute to our understanding of processes in development, homeostasis, regeneration, and disease, and will also potentially lead to new therapies.

PI_NAMEs: KIM, TAEYOON  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: 3-Dimensional;Alginates;Automobile Driving;Behavior;Biological Process;Cell Culture Techniques;Cell division;cell growth;Cell membrane;Cell Mobility;cell osmotic pressure;Cell Separation;cell type;Cell-Matrix Junction;Cells;Characteristics;Collagen;Collagen Type I;Complex;Computer Models;Cultured Cells;defined contribution;Development;disability;Disease;Elasticity;Experimental Models;experimental study;Extracellular Matrix;Feedback;force feedback;G1 Phase;Gel;Generations;Goals;Growth;Homeostasis;Human;insight;Ion Channel;Knowledge;Location;Measurement;Mechanics;Mediating;Mission;Mitosis;Mitotic;Modeling;Morphology;Movement;Myosin ATPase;Natural regeneration;novel;novel therapeutics;Osmotic Pressure;Physiological;Process;Property;Public Health;Recommendation;Relaxation;Research;spheroids;Stress;Text;three dimensional cell culture;United States National Institutes of Health;viscoelasticity

PROJECT_TITLE: Mitosis in Confining Microenvironments


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease

ORG_DEPT: MISCELLANEOUS

PHR: PROJECT NARRATIVE Mitral regurgitation is the backward leakage of blood towards the lungs when the heart contracts, often as a consequence of heart attacks or degeneration of the mitral valve tissue. Current surgical repair techniques for mitral regurgitation have alarmingly high rates of long-term regurgitation recurrence, and clinical trials studying transcatheter edge-to-edge repair have reported highly contradictory outcomes, largely due to the widespread variation in patients' preoperative clinical characteristics. Our objective is to understand how the mitral regurgitation disease process and transcatheter repair alter the mitral valve's geometry and function, and to preoperatively simulate transcatheter repair directly on a 3D model of the patient's mitral valve to predict long-term recurrence and select the best method of repair to improve the patient's long-term outcomes.

PI_NAMEs: SIMONIAN, NATALIE  (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Adverse effects;Age;Behavior;Biological Markers;Biomechanics;Blinded;Blood;Calibration;Cardiomyopathies;Cardiovascular Diseases;case-by-case basis;Characteristics;Clinical;clinical imaging;Clinical Trials;Clip;cohort;Complex;computational pipelines;Computer Models;Contracts;Data;Data Set;Databases;Disease;Elements;Etiology;experience;Extravasation;Geometry;Growth;Heart;Heterogeneity;Human;Image;imaging modality;improved;in silico;in vivo;insight;Ischemia;Lead;Left atrial structure;Left ventricular structure;Link;Lung;mechanical load;Methods;Mitral Valve;Mitral Valve Insufficiency;Myocardial Degeneration;Myocardial Infarction;Nature;novel;Operative Surgical Procedures;Outcome;outcome prediction;Patient imaging;patient population;patient stratification;Patient-Focused Outcomes;Patients;Population;Positioning Attribute;Postoperative Period;postoperative state;pre-doctoral;preoperative state;Procedures;Process;Prognostic Factor;Property;Race;Radial;Recurrence;repair model;repaired;Reporting;Selection for Treatments;sex;Shapes;simulation;Stress;success;Techniques;Testing;Therapeutic;Three-Dimensional Echocardiography;three-dimensional modeling;Time;Tissues;Treatment Efficacy;treatment optimization;Treatment outcome;treatment strategy;trial comparing;Variant;Work

PROJECT_TITLE: In-Vivo Patient-Specific Optimization of Transcatheter-Edge-to-Edge Repair in Mitral Regurgitation


NIH_SPENDING_CATS: Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: Project Narrative Pneumonia is a major cause of death worldwide and involves widely varying responses in the lung that are postulated to cluster into distinct sub-phenotypes. Different sub-phenotypes would be responsive to different host-directed treatments, making elucidating and characterizing lung pathobiology variations a major research priority. This F32 will provide training in lung pathobiology and help define pulmonary underpinnings of pneumonia sub-phenotypes, which will aid in the development and proper utilization of host-directed pneumonia treatments.

PI_NAMEs: HILLER, BRADLEY  (contact)

PROJECT_TERMS: 2019-nCoV;Age;Air;Alveolar;Alveolus;Autopsy;Biology;Blood;C57BL/6 Mouse;Cause of Death;Clinical;Clinical Trials;Coagulation Process;Deposition;design;Development;Elderly;Escherichia coli;experience;Feedback;Fibrin;Freezing;Functional disorder;Histopathology;Human;human model;Immune;Immune response;Immunohistochemistry;improved;Infection;Infiltration;Influenza A virus;Klebsiella pneumoniae;Life;Link;Lung;Lung infections;Lymphocyte;Lymphocytic Infiltrate;Measures;Mediating;Mediator;Modeling;mouse model;Mus;neutrophil;Neutrophil Activation;Neutrophil Infiltration;Neutrophilia;pathogen;Pathogenesis;Pathology;Patient Care;Patients;Pattern;Phenotype;Plasma;Pneumonia;pneumonia model;pneumonia treatment;Polymers;Pulmonary Pathology;Research Priority;respiratory pathogen;response;Sampling;Sendai virus;Serotyping;Severities;single nucleus RNA-sequencing;Stains;Streptococcus pneumoniae;Structure of parenchyma of lung;Testing;Therapeutic;Tissue Sample;Training;Variant;Virus Diseases

PROJECT_TITLE: Sub-phenotyping pneumonia by lung pathobiology


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Coronaviruses;Data Science;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PHR: The modeling platforms will be unique to study large-scale protein conformational changes by bridging  multiple spatial and temporal scales involved in the virus fusion process. The machine learning facilitated  enhanced sampling schemes, molecular and membrane models are generalizable, and should be broadly  applicable for the study of many viruses and pathogens, and other processes involving protein  conformational changes including endocytosis, exocytosis and sperm-egg fertilization.

PI_NAMEs: LIU, JIN  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: 2019-nCoV;Acceleration;Address;Biological;Biological Process;Cell membrane;Cells;Chimeric Proteins;Cholesterol;Complex;Computer Models;Computer Simulation;COVID-19 pandemic;Dengue;Development;dimension reduction;effective intervention;Endocytosis;env Gene Products;Event;Exocytosis;experience;experimental study;flexibility;Freedom;Future;Grain;Health;Herpesviridae;HIV;Human;Infection;innovation;insight;Lipids;Liquid substance;Machine Learning;machine learning algorithm;machine learning method;Measurement;Membrane;Membrane Fluidity;Membrane Fusion;membrane model;Methods;model generalizability;Modeling;Molecular;Molecular Conformation;molecular modeling;Monoclonal Antibodies;Morbidity - disease rate;mortality;multi-scale modeling;multidisciplinary;mutant;nanosized;National Institute of General Medical Sciences;neural network;novel;novel coronavirus;obligate intracellular parasite;Organism;pathogen;Pathway interactions;Process;Protein Conformation;Proteins;Reaction;Research;Role;Sampling;Scheme;Simplexvirus;simulation;Solid;Spanish flu;sperm cell;Structure;Surface;Techniques;Variant;Viral;Viral Fusion Proteins;Virion;Virus;Virus Diseases;zygote

PROJECT_TITLE: DMS/NIGMS 2: Integrated Analysis of Fusion Protein Conformational Changes for Virus Entry


NIH_SPENDING_CATS: Brain Disorders;Congenital Structural Anomalies;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: ATLANTA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Menkes disease is a rare genetic condition that disrupts copper in the body and prominently affects the brain, with neurodegeneration and other neurological symptoms appearing soon after birth. Copper plays a role not only in Menkes but in a number of neurological conditions including Parkinson’s and ALS, consistent with the high energy demands of the nervous system and the crucial role of copper in mitochondrial function. The proposed research will clarify the metabolic pathways responsive to copper and their effects on neuronal function. The application of this knowledge will inform our understanding, research, and treatment of neuropathology of diseases known to be associated with dysregulated metals and/or metabolism for which there are currently limited therapeutics.

PI_NAMEs: LANE, ALICIA R (contact)

PROJECT_TERMS: Acute;Affect;Animal Model;Binding;Bioenergetics;Biological;Birth;Brain;calcium indicator;Cell Death;cell injury;Cells;cellular engineering;chromatin immunoprecipitation;Copper;cytochrome c oxidase;Data;Disease;Engineering;enzyme activity;Epilepsy;epileptic encephalopathies;Equilibrium;Exhibits;experimental study;extracellular;Gene Expression;Genes;Genetic Diseases;Genetic Models;Genetic Transcription;Glycolysis;Goals;Homeostasis;Human;Hypoxia;Infant;inorganic phosphate;Intake;Intellectual functioning disability;Knock-out;Knowledge;Link;Menkes Kinky Hair Syndrome;Metabolic;Metabolic Pathway;metabolic phenotype;Metabolism;Metals;Mitochondria;mitochondrial metabolism;Modeling;Molecular;molecular phenotype;Molecular Target;mouse model;Mus;Mutant Strains Mice;Mutation;nano-string;National Research Service Awards;Nerve Degeneration;Nervous System;neuroblastoma cell;Neurologic;Neurologic Symptoms;neuron loss;neuronal excitability;Neurons;neuropathology;neurotransmission;Neurotransmitters;Nutrient;Oxidative Phosphorylation;Oxygen;Oxygen saturation measurement;Parkinson Disease;Pathology;Pathway interactions;Phenotype;Predisposition;Production;protein expression;rare genetic disorder;Reactive Oxygen Species;Regulation;Research;Respiration;response;Role;Testing;Therapeutic;transcription factor;transcriptome sequencing;transcriptomic profiling

PROJECT_TITLE: Metabolic Mechanisms of Copper-Dependent Neurodegeneration and Excitability in Menkes Disease


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Post-Traumatic Stress Disorder (PTSD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: PROJECT NARRATIVE This multi-method project aims to better understand behavioral health disparities among racial/ethnic minority and women post-9/11 veterans, who make up a growing proportion of the veteran population but for which few theoretically informed, longitudinal studies exist. Using qualitative interviews, repeated longitudinal assessments, and innovative machine learning methods, we will test a comprehensive model of individual and environmental factors contributing to disparities in alcohol use, attitudes towards care, and actual care receipt among a large and diverse sample of post-9/11 veterans recruited outside of VA settings.

PI_NAMEs: DAVIS, JORDAN P (contact);PEDERSEN, ERIC R.

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: Address;African American;Alcohol consumption;alcohol research;Alcohols;Attitude;Behavior;behavior influence;behavior prediction;Behavioral;behavioral health;Black race;care systems;Caring;catalyst;Censuses;Chronic;community violence;Data;Data Set;demographics;deprivation;Disadvantaged;Discrimination;Disease;Disparity;distilled alcoholic beverage;Economics;Enrollment;Ensure;Environmental Risk Factor;ethnic diversity;ethnic minority;ethnic minority population;Ethnic Minority Women;experience;follow-up;Future;health care availability;health care disparity;Health care facility;health care service;health care service utilization;health difference;health disparity;Healthcare;Healthcare Systems;Hispanic;Income;Individual;Inequality;innovation;Intervention;Interview;Life;Link;Lived experience;Longitudinal cohort;Longitudinal Studies;machine learning method;machine learning model;male;Measurement;men;Mental Depression;Methods;microaggression;Military Personnel;military trauma;military veteran;Minority;Modeling;Neighborhoods;Not Hispanic or Latino;Outcome;outreach;perceived discrimination;Policies;post 9/11;Post-Traumatic Stress Disorders;Poverty;Prevention;Race;racial discrimination;racial minority;racial minority population;racial minority women;racism;Recommendation;Recording of previous events;recruit;Reporting;Research;resilience;Role;Sampling;segregation;Series;Sex Discrimination;Sexism;Sexual Harassment;social;stressor;Surveys;Symptoms;System;Testing;theories;Time;Veterans;Veterans Health Administration;Violence;Woman;Work

PROJECT_TITLE: Multimethod Examination of Individual and Environmental Factors Associated with Alcohol Use and Behavioral Health Care Disparities Among Racial/Ethnic Minority and Women Veterans

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Immunotherapy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: We propose to develop and validate a technology for the multi-scale profiling of cells at the single-cell level. We anticipate that this technology will fundamentally alter the characterization of immune cells in the context of immunotherapy and vaccines.

PI_NAMEs: VARADARAJAN, NAVIN  (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Adoptive Cell Transfers;Antibodies;antibody immunotherapy;Apoptosis;B lymphoid malignancy;Bar Codes;Biological Assay;Biological Markers;Biology;Biomanufacturing;cancer cell;cancer therapy;CD19 gene;cell behavior;Cell Communication;Cell Cycle;cell motility;Cell Physiology;Cell Proliferation;Cell Therapy;cell type;Cells;Cellular Assay;Cellular biology;cellular imaging;Cellular Morphology;chimeric antigen receptor;chimeric antigen receptor T cells;Classification;Clinical;Clinical Data;clinically relevant;Computer Vision Systems;contrast imaging;convolutional neural network;Crosslinker;Cytogenetics;Cytometry;Data;data modeling;deep neural network;Detection;Development;Disease remission;DNA;engineered T cells;Engineering;Exhibits;Gene Expression;genotyped patients;Goals;Heterogeneity;Human;Image;Image Analysis;imaging system;Immune;Immune response;Immune system;Immunotherapy;In Vitro;Individual;Infusion procedures;Label;Link;Machine Learning;Malignant Neoplasms;manufacture;Maps;Measurement;metabolic profile;Microscopy;migration;Molecular;Molecular Profiling;morphometry;Motility;Motion;multiscale data;nano;neoplastic cell;Nuclear Translocation;Oncology;Organelles;patient response;Patients;Permeability;Phase;Phenotype;Population;Proliferating;Property;Protein translocation;Research Personnel;Resolution;response;Retrieval;sample fixation;single cell technology;single-cell RNA sequencing;software systems;Specificity;Subcellular structure;success;System;Systems Development;T-Cell Receptor;T-Lymphocyte;Technology;technology development;technology validation;Therapeutic;Tissues;Training;tumor;United States Food and Drug Administration;Vaccines;Validation;Work

PROJECT_TITLE: MusIC: A multi-scale technology for integrating dynamic cellular function and molecular profiles

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Brain Disorders;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: The human polyomavirus JC (JCPyV) infects most people for life but only causes diseases in persons with a compromised immune system. JCPyV reactivation in the brain causes the often fatal progressive multifocal leukoencephalopathy (PML). There is currently no effective treatment for PML. Natural killer cells help the body defend itself against viral infections, and the proposed studies will determine how these immune cells contribute to the control of JCPyV replication and curtail PML. The outcome of these studies will provide basis for potentially discover immune targets for novel therapeutics against JCPyV.

PI_NAMEs: JOST, STEPHANIE ;TAN, CHEN SABRINA (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Adult;Anti-viral Response;Antibodies;antibody-dependent cell cytotoxicity;Antibody-Dependent Enhancement;Antigens;Autoimmune Diseases;Autologous;Brain;Cell Physiology;Cells;Clinical;Cloning;cytokine;Cytomegalovirus;cytotoxic;Data;Development;Diagnosis;Disease;effective therapy;Effector Cell;Endowment;Epitopes;Exhibits;Future;Gene Expression Profile;Hepatitis C virus;Herpesviridae Infections;HIV;HIV Seropositivity;Human;Immune;immune function;Immune response;Immune system;Immune Targeting;Immunocompromised Host;Immunologic Deficiency Syndromes;Immunotherapeutic agent;Immunotherapy;Impairment;Individual;influenzavirus;Innate Immune System;innovation;Intervention;Investigation;JC Virus;Knowledge;Life;Ligands;Mediating;Memory;Morbidity - disease rate;mortality;mouse model;multiple sclerosis patient;Natural Killer Cells;Neoplasms;new therapeutic target;novel;Onset of illness;Outcome;Outcome Study;Pathogenesis;Patients;Peptides;Persons;Phenotype;Play;prevent;Progressive Disease;Progressive Multifocal Leukoencephalopathy;Property;protective efficacy;receptor;Reporting;response;Role;Sampling;sensitizing antigen;Survivors;Testing;Time;Viral;Viral Load result;Viral Physiology;Virus;Virus Diseases;Work

PROJECT_TITLE: NK cell responses to JC polyomavirus

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Telehealth

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

PHR: PROJECT NARRATIVE Assertive sexual communication is linked to higher condom use rates, and, in turn, lower rates of human immunodeficiency virus (HIV) and sexually transmitted infections (STIs). However, adolescent sexual minority males (ASMM), a population disproportionately at-risk for acquiring HIV/STIs, do not receive adequate information or skills surrounding assertive sexual communication with a partner. The proposed project will help us adapt an existing digital intervention to increase sexual assertiveness among ASMM, with a specific focus on condom negotiation, to increase condom use rates.

PI_NAMEs: JAVIDI, HANNAH  (contact)

PROJECT_TERMS: Address;Adolescent;Advocate;Affect;Age;Area;Assertiveness;Attitude;Award;Behavior;behavior change;Behavior Therapy;behavioral health intervention;behavioral outcome;career;career development;Clinical Trials;Code;Coitus;Collaborations;Communication;community led intervention;condom use rate;condoms;Consent;Cost efficiency;Data;Dedications;design;Development;digital health;digital intervention;disparity reduction;effectiveness/implementation design;Elements;Evaluation;experience;Feedback;Focus Groups;follow-up;Future;Gender;General Population;Goals;Health;Health behavior change;health disparity;Health Sciences;Heterosexuals;high risk;high school;HIV;Hour;implementation determinants;implementation evaluation;implementation facilitators;implementation science;implementation/effectiveness;improved;Indiana;Intervention;Knowledge;Language;Lead;Learning;Lesbian Gay Bisexual Transgender Queer;Link;male;male health;Mediation;Medical;medical schools;Mentors;Mentorship;Methodology;Methods;Minority Groups;National Institute on Minority Health and Health Disparities;Needs Assessment;non-heterosexual;Outcome;Parents;Participant;peer;Persuasive Communication;Phase;Planning Theory;Population;Privacy;Program Effectiveness;Program Evaluation;programs;Public Health;Public Health Schools;Qualitative Research;Randomized, Controlled Trials;Recording of previous events;recruit;Reduce health disparities;Reporting;Research;Research Activity;Research Methodology;Research Personnel;Research Project Grants;response;responsible research conduct;Risk;Risk Reduction;Sampling;School-Age Population;Schools;Scientist;Self Efficacy;Sex Behavior;Sex Education;sexual encounter;Sexual Health;sexual minority male;sexual minority youth;sexually active adolescent;Sexually Transmitted Diseases;skill acquisition;skills;Social Sciences;STI prevention;Surveys;Teenagers;Testing;theories;therapy design;Training;Training Activity;transmission process;Universities;Update;usability;viral transmission;Work;Writing;Youth

PROJECT_TITLE: A digital health intervention to increase condom use among adolescent sexual minority males


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Rural Health;Social Determinants of Health

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE The United States is experiencing a healthcare clinician maldistribution that negatively affects access to care and health outcomes for millions of Americans. The rural-urban access to care disparity is a well-known but growing public health threat for rural Americans. The findings of this study will identify an optimal set of policy options and incentives that would attract clinicians to a rural area.

PI_NAMEs: GILLETTE, CHRIS  (contact);OSTERMANN, JAN

PROGRAM_OFFICER_NAME: HUELSNITZ, CHLOE OLIVIA

PROJECT_TERMS: access disparities;Address;Affect;American;Appalachian Region;Area;Characteristics;Clinical;Communities;Data;Decision Analysis;Decision Making;design;Disparity;disparity reduction;Ensure;Equitable healthcare;Equity;experience;experimental study;Face;Future;Health;health care availability;Health Care Costs;health disparity;health inequalities;health professional shortage areas;Health Promotion;Health Services Accessibility;Healthcare;improved;Incentives;Individual;Inequity;inner city;innovation;Life;Location;Medical;Medicine;Methodology;Methods;Mission;Morbidity - disease rate;mortality;National Institute on Minority Health and Health Disparities;novel;Nurse Practitioners;Occupations;Outcome;Patients;Persons;Physician Assistants;Physicians;pilot test;Policies;Policy Maker;Population;Positioning Attribute;preference;Primary Care;Provider;Public Health;recruit;Research;Research Methodology;Rest;Rural;rural Americans;Rural Appalachia;rural area;Rural Population;Students;suburb;Survey Methodology;Surveys;Time;United States;uptake;urban area;urban disparity;Work;Workplace

PROJECT_TITLE: AHCRA: Access to Health Care in Rural Appalachia


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: BOSTON MEDICAL CENTER

PHR: Project Narrative Patients with limited English proficiency (LEP) receive inferior preparation to leave the hospital after a medical admission. The goal of this application is to address disparities in patient safety, clinical outcomes, and patient experience related to the hospital discharge process for patients with LEP. The proposed Aims will adapt an evidence-based intervention (ReEngineered Discharge), which has been shown to improve outcomes around hospital discharge, to the needs of patients with LEP, thereby directly aligning with NIMHD’s Strategy to “adapt evidence-based interventions for implementation and evaluation within health disparity populations.”

PI_NAMEs: AUSTAD, KIRSTEN  (contact)

PROGRAM_OFFICER_NAME: SOLIS SANABRIA, CAROLINA VANESSA

PROJECT_TERMS: acceptability and feasibility;Address;Admission activity;Adverse event;Appointment;barrier to care;Boston;Calendar;care coordination;care providers;Caring;Client satisfaction;Clinical;Clinical Trials Design;Communication Barriers;Communication difficulty;Communities;Comprehension;Conduct Clinical Trials;Dangerousness;Data;Disparity;Disparity population;disparity reduction;Educational process of instructing;Effectiveness;effectiveness/implementation trial;Engineering;Ensure;Environment;Equity;Ethnic Origin;Evaluation;evidence base;Evidence based intervention;Exclusion;experience;experimental study;Face;Failure;Family;feasibility trial;Frequencies;Goals;Haitian;health disparity;health disparity populations;health equity;Health equity research;high risk;Home;Hospital Costs;hospital readmission;Hospitalists;Hospitalization;Hospitals;Hybrids;implementation intervention;implementation outcomes;implementation science;improved;improved outcome;Inequity;Inferior;insight;Instruction;Intervention;Interview;Knowledge;Language;Lead;Limited English Proficiency;Linguistics;Logit Models;Measures;Medical;Medical center;medication compliance;Medication Errors;Mentors;Methodology;Methods;Minority Groups;Modeling;Modification;multi-component intervention;multidisciplinary;National Institute on Minority Health and Health Disparities;Nurses;Outcome;Participant;Patient Care;Patient Discharge;Patient Education;Patient Preferences;patient safety;Patients;person centered;Pharmaceutical Preparations;pilot trial;poor health outcome;Population;Positioning Attribute;preference;Preparation;Primary Care;Process;programs;Provider;Randomized, Controlled Trials;readmission rates;recruit;Reporting;Research;Research Personnel;response;retention rate;Review Literature;Safety;safety net;Sampling;Science;Series;service coordination;Site;social health determinants;social vulnerability;Spanish;standardize measure;Structure;success;Survey Methodology;Symptoms;Testing;Time;Training;Translations;treatment as usual;Underserved Population;United States;verbal;Work;Writing

PROJECT_TITLE: Adapting an Evidence-Based Intervention to Improve the Hospital Discharge Process for Patients with Limited English Proficiency


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

PHR: PROJECT NARRATIVE: Fragile X Syndrome, the most common form of inherited intellectual disability and monogenic cause of autism, is caused by the loss of the RNA-binding protein FMRP. FMRP regulates translation by cooperating with microRNAs; however, the magnitude of microRNA dysregulation in human-specific models of FXS remains unclear. This study will determine the extent of microRNA dysregulation in human models of FXS and reveal whether RNA-binding proteins and microRNAs operate bimodally.

PI_NAMEs: KOSTI, ADAM  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: 3-Dimensional;Affect;Animal Model;autism spectrum disorder;base;Base Pairing;Biochemical;Brain;Cell Culture Techniques;Cells;Clinical Trials;Communities;Coupled;Development;Environment;Event;experimental study;Failure;Fellowship;FMR1 gene;Fragile X Syndrome;Gene Expression;Gene Expression Regulation;gene repression;Gene Silencing;Goals;Human;human model;Individual;induced pluripotent stem cell;Inherited;Intellectual functioning disability;Light;Malignant Neoplasms;Mammals;Measures;Mediating;medical schools;Mentorship;messenger ribonucleoprotein;Messenger RNA;Methods;MicroRNAs;Microscopy;Modality;Modeling;Molecular;mouse model;Mus;neural;neuronal cell body;Neurons;neuropsychiatric disorder;Organoids;Pattern;Phenotype;posttranscriptional;Primates;Principal Investigator;Process;Production;Prosencephalon;Protein Biosynthesis;Proteins;Proteome;Regulation;Repression;RNA;RNA Interference;RNA-Binding Proteins;RNA-Induced Silencing Complex;Role;Schizophrenia;skills;Small RNA;Synapses;Techniques;Testing;Training;Transcript;transcriptome sequencing;Translational Regulation;Translational Repression;Translations;Universities

PROJECT_TITLE: Mechanisms of microRNA dysregulation in Fragile X Syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F03A-E(20)]


NIH_SPENDING_CATS: Clinical Research;Social Determinants of Health

PHR: The physician-scientist pipeline persistently struggles to attract and retain individuals historically underrepresented in medicine (URiM), including individuals who are Black, Hispanic, American Indian or Alaskan Native, Native Hawaiian, and other Pacific Islander. This is a 5-year, longitudinal, mixed-methods study that will identify trajectories of research career intentions, and determinants thereof, in 400 URiM students matriculating into MD programs and compare these with trajectories and determinants among 200 non-URiM students. This study is significant and innovative because it will provide granular data about the formative experiences of URiM MD students that can be used to support growth of the racial and ethnic diversity of the physician-scientist workforce.

PI_NAMEs: BOATRIGHT, DOWIN ;CHAUDHRY, SARWAT I (contact)

PROJECT_TERMS: Affect;Alaska Native;American;American Indians;Association of American Medical Colleges;Black race;career;Clinical;Clinical Medicine;Clinical Sciences;cohort;Data;Development;Discrimination;Disparity;Doctor of Philosophy;Engineering;ethnic diversity;ethnic minority;Ethnic Origin;Ethnic Population;Evaluation Research;Evolution;Exclusion;experience;follow-up;Funding;Future;Growth;health inequalities;Hispanic;Individual;Influentials;innovation;Institution;Intention;interest;Interview;Leadership;Lived experience;matriculation;Measures;Medical Education;medical schools;Medical Students;Medicine;Mentorship;Methodology;Methods;Native Hawaiian or Other Pacific Islander;novel;Patients;perceived discrimination;Physicians;Play;Positioning Attribute;pressure;programs;Publishing;Qualitative Methods;Race;racial diversity;racial minority;racial population;racism;Reduce health disparities;Reporting;Research;Research Design;Residencies;Role;Sampling;Scholarship;Schools;Scientist;Shapes;Students;success;Surveys;Time;Training;Underrepresented Populations;Underrepresented Students;United States National Academy of Sciences;United States National Institutes of Health;Work

PROJECT_TITLE: Longitudinal Evaluation of Research Career Intentions among Students Underrepresented in Medicine

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(02)M]


NIH_SPENDING_CATS: Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative. Neurons and astrocytes have unique demands in regulating the quality of their proteome that require the autophagy degradation pathway, but how autophagy is regulated to facilitate cell type-specific functions and responses to stress is largely unknown. This proposal will elucidate cell type-specific functions for the autophagy receptor p62 in neurons and astrocytes, and how ALS-linked mutations in p62 impair p62 function in each cell type. Insights from this study will generate new ideas for how neurons and astrocytes use p62 differently in basal, stress, and disease conditions, and may uncover new and more precise cell-specific targets to modify autophagy for the treatment of neurodegenerative disease.

PI_NAMEs: SIDIBE, DAVID KADER (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Affect;Antioxidants;Area;Astrocytes;Autophagocytosis;Autophagosome;bafilomycin A1;Binding;biological adaptation to stress;cell type;Cells;Cellular Stress;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;combat;Cytoplasm;Data;Defect;Degradation Pathway;design;Disease;falls;Genes;Goals;Impairment;in vivo;inhibitor;insight;Investigation;knock-down;Knowledge;Link;Lysosomes;Measures;Metabolic stress;mutant;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neurons;neuroprotection;Oxidative Stress;Oxidative Stress Induction;Pathology;Pathway interactions;protein aggregation;Proteins;Proteome;proteotoxicity;receptor;Regulation;Resolution;response;Role;Serine;Small Interfering RNA;Specific qualifier value;Stress;Structure;superoxide dismutase 1;System;targeted treatment;Testing;therapeutic development;transcription factor;Ubiquitin;Ubiquitination;Western Blotting

PROJECT_TITLE: Defining cell type-specific functions for the selective autophagy receptor p62 in neurons and astrocytes


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lupus;Patient Safety;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on improving patient-clinician communication as a mechanism for improving medication adherence and health outcomes for patients with SLE. The project is relevant to NIMHD’s mission and directly addresses the purpose of the funding opportunity on Patient-Clinician Relationship by testing an intervention aimed to improve equity in communication and medication adherence for patients with SLE, a population that experience substantial health disparities.

PI_NAMEs: SUN, KAI  (contact)

PROGRAM_OFFICER_NAME: PATEL, ANURADHA DIPAK

PROJECT_TERMS: Address;Adherence;Adoption;Area;Autoimmune Diseases;Award;Behavior;black patient;Black Populations;Black race;Clinic;Clinic Visits;Cluster randomized trial;Communication;Conduct Clinical Trials;culturally appropriate intervention;Data;Decision Making;Disparity;Education;Equity;experience;Eye;flexibility;Frequencies;Funding Opportunities;Goals;Health;health care disparity;health disparity;Health system;hybrid type 1 design;implementation evaluation;implementation outcomes;implementation science;improved;Incidence;innovation;Intervention;intervention delivery;intervention effect;Kidney Failure;Life Expectancy;Lupus;Maintenance;Mediating;Mediation;Medical;medication compliance;medication nonadherence;Medicine;Methods;Mission;Modeling;multidisciplinary;National Institute on Minority Health and Health Disparities;Organ;Outcome;outcome disparities;Patient Care;Patient Compliance;Patient Noncompliance;patient oriented;Patient Outcomes Assessments;patient-clinician communication;Patient-Focused Outcomes;Patients;Persons;Pharmacy facility;pilot test;poor health outcome;Population;Positioning Attribute;Public Health;Quality of life;racial disparity;racial diversity;Randomized;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Research;Rheumatology;Severities;skills;Standardization;success;Surveys;System;Systemic Lupus Erythematosus;Techniques;Testing;Therapeutic;tool;Training;treatment as usual;trial comparing;Trust;Visit;Work

PROJECT_TITLE: CO-LEADER: Intervention to Improve Patient-Provider Communication and Medication Adherence among Patients with Systemic Lupus Erythematosus

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ORG_NAME: DANA-FARBER CANCER INST

PHR: We've used kidney cancer, one of the 10 most common cancers in the U.S., as a prototype for treating cancers that are caused by “undruggable” mutations (in this case, inactivation of the VHL tumor suppressor gene). We aim to identify new kidney cancer treatments and to establish paradigms that can be applied to other cancers.

PI_NAMEs: KAELIN, WILLIAM G. (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: alpha ketoglutarate;beta catenin;Binding;Biochemical;Biological Assay;c-myc Genes;Cachexia;Cancer Etiology;cancer therapy;CDK4 gene;Cell Line;Cells;Chemicals;Clear cell renal cell carcinoma;Clustered Regularly Interspaced Short Palindromic Repeats;Compensation;Cyclin D1;Development;DHODH gene;Dioxygenases;DNA;Drosophila genus;Drug Targeting;Endogenous Retroviruses;Event;Failure;Genetic Screening;Genomics;Glioma;histone demethylase;Human;Hydroxylation;Hypercalcemia;hypoxia inducible factor 1;immunogenic;inhibitor;insight;interest;knockout gene;KRAS2 gene;leukemia;Link;Malignant Neoplasms;mouse model;Multiple Myeloma;mutant;Mutation;Oncoproteins;Oxygen;paralogous gene;Patients;Peptides;Procollagen-Proline Dioxygenase;programs;Protein Secretion;Proteins;prototype;recruit;Renal Carcinoma;Resistance;Retinoblastoma Protein;Site;small molecule;somatic cell gene editing;Source;Thalidomide;transcription factor;Translating;tumor;ubiquitin ligase;Validation;Vegf Inhibitor;VHL gene;VHL Gene Inactivation;Von Hippel-Lindau Tumor Suppressor Protein;Work

PROJECT_TITLE: The von Hippel-Lindau Tumor Suppressor Gene and Kidney Cancer: Insights into Oxygen Sensing and Treating Cancers Caused by Undruggable Mutations


NIH_SPENDING_CATS: Bioengineering;Biotechnology

PHR: Project Narrative Understanding the complex nanoscale spatial architecture of organelles is highly relevant to public health as it provides mechanistic and functional insights into the cellular processes that are disrupted in cancer, neurodegenerative and developmental diseases (e.g. ciliopathies). In this project we will develop an innovative and flexible multiplexed imaging approach to visualize the nanoscale organization and remodeling of cellular organelles.

PI_NAMEs: BEWERSDORF, JOERG  (contact);TOOMRE, DEREK K.

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 3-Dimensional;Acceleration;Algorithms;Alzheimer's Disease;Anatomy;Architecture;Area;automated analysis;Biological;biological development;Biology;Blinking;Cell membrane;Cell Physiology;Cells;Cellular biology;Cilia;ciliopathy;Color;Complex;cost;Cues;Data;Data Set;Development;developmental disease;Diabetes Mellitus;Disease;DNA;Electron Microscopy;Epidermal Growth Factor Receptor;extracellular;Face;Feedback;flexibility;Functional disorder;Future;Goals;Golgi Apparatus;Image;Image Analysis;imaging approach;imaging platform;improved;Individual;innovation;insight;instrumentation;interest;Label;Light;light microscopy;Link;Malignant Neoplasms;Maps;Medial;Membrane;meter;microbial;Microfluidics;Molecular;Morphology;multiplexed imaging;nano;nanoscale;nanoscope;Nanoscopy;Nervous System Disorder;Neurodegenerative Disorders;new technology;novel;open source;Oranges;Organelles;Pathogenesis;Physics;Physiological;PIK3CG gene;Proteins;Proto-Oncogene Proteins c-akt;Public Health;Reagent;Reporter;Resolution;Sampling;segregation;Signal Transduction;single molecule;Sorting;Specificity;Speed;superresolution imaging;superresolution microscopy;Surface;System;Techniques;Technology;technology validation;ultra high resolution;user-friendly;Validation;Visualization

PROJECT_TITLE: Development of a Versatile Multiplexing Nanoscopy Platform for Cell Biology


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Contraception/Reproduction;Infertility;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation;Urologic Diseases

ORG_CITY: Pittsburgh

ORG_NAME: MAGEE-WOMEN'S RES INST AND FOUNDATION

PHR: PROJECT NARATIVE Immature testicular tissues have been cryopreserved for thousands of patients worldwide with anticipation that they can be thawed in the future and matured to produce sperm. Autologous transplantation of frozen/thawed testicular tissues/cells will not be appropriate or safe for all patients. In this proposal, we test three different physiomimetic systems for maturing immature testicular tissues or cells and producing sperm outside the body. In addition to clinical applications, these systems can be used to gain fundamental insights into human testis development or used as platforms to screen of toxicologic or pharmaceutical compounds or develop drugs that promote or prevent sperm production.

PI_NAMEs: LARONDA, MONICA M;ORWIG, KYLE EDWIN (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: 3-Dimensional;3D Print;Adult;Age;Air;Animals;Architecture;Assisted Reproductive Technology;Autologous;Autologous Transplantation;Benchmarking;bioink;Blood-Testis Barrier;Bone Marrow Transplantation;boys;cancer cell;cancer therapy;cell age;Cell Fraction;Cell Maturation;Cells;Chemotherapy and/or radiation;Chicago;Clinic;clinical application;Cryopreservation;Cryopreserved Tissue;Development;drug development;egg;Embryo;Endothelial Cells;Engineering;Excision;experience;Extracellular Matrix;Family suidae;Fertility;Fertilization;Freezing;Future;gender affirming therapy;gender dysphoria;Genetic Transcription;Germ Cells;girls;Goals;Gonadotropins;Grant;Human;human model;Hydrogels;In Vitro;in vivo;Individual;Infertility;insight;Institution;leukemia;leydig interstitial cell;Life;Liquid substance;male;Malignant neoplasm of testis;Medical;Microfluidic Microchips;Microfluidics;Morphology;Mus;Neonatal;Newborn Infant;next generation;novel;novel strategies;oocyte cryopreservation;Organ Culture Techniques;Organoids;Ovarian Tissue;Patients;Pediatric Hospitals;Peptides;Pharmaceutical Preparations;Pharmacologic Substance;Positioning Attribute;Pregnancy;prepuberty;prevent;Printing;Production;Proteomics;Puberty;Publishing;reconstruction;Reproducibility;Reproduction;reproductive;Reproductive Technology;Research;Resources;restoration;Rodent Model;safe patient;scaffold;screening;Seminiferous tubule structure;sertoli cell;Somatic Cell;sperm cell;Spermatogenesis;Stem cell transplant;stem cells;Structure;Support System;System;Technology;Testicular Tissue;Testing;Testis;Testosterone;Tissue Grafts;Tissue Survival;Tissues;transgender;Translating;Transplantation;Tubular formation

PROJECT_TITLE: Organizing and Reorganizing Human Testis Development In Vitro