ORG_CITY: PITTSBURGH

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE The adenosine-producing (adenosinergic) pathway in tumor-derived exosomes (TEX) emerges as a critical mechanism in suppression of T-cell responses to immunotherapy and in promoting tumor progression. This project will further elucidate the role of TEX in adenosine-mediated immune suppression as well as tumor progression in cancer and will assess the performance of adenosinergic activity in TEX as a potential biomarker of prognosis and response to therapy in patients with cancer.

PI_NAMEs: JACKSON, EDWIN KERRY;WHITESIDE, THERESA L. (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Adenosine;angiogenesis;Apoptosis;Automobile Driving;B-Lymphocytes;Biochemical Pathway;Biogenesis;Biological Assay;Biological Markers;Blood;Body Fluids;cancer biomarkers;Cancer Patient;cancer therapy;carcinogenesis;CD8B1 gene;Cell Line;Cell Physiology;Cell surface;Cells;checkpoint inhibition;Chemistry;Communication;Cyclic ADP-Ribose;Cyclic AMP;Data;Disease;Distant;Effector Cell;Enzymes;Erythrocytes;Exhibits;exosome;extracellular vesicles;G-Protein-Coupled Receptors;Growth;growth promoting activity;Half-Life;Human;Immune;Immune Cell Suppression;immune checkpoint;Immune checkpoint inhibitor;immune function;Immune system;Immune System Diseases;Immune Targeting;Immunologics;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;Infiltration;insight;Laboratories;Ligands;Link;Macrophage;Malignant Neoplasms;Measures;Mediating;Melanoma;Melanoma Cell;Melanoma patient;Messenger RNA;Metabolism;Methods;Molecular;mouse model;Mus;Names;Natural Killer Cells;Neoplasm Metastasis;neoplastic cell;new therapeutic target;Normal Cell;novel;Nucleic Acids;Parents;Pathway interactions;Patients;Performance;Phenotype;Plasma;Play;potential biomarker;Prognosis;prognosis biomarker;Proliferating;Proteins;Purinergic P1 Receptors;Purines;rational design;receptor;Regulatory T-Lymphocyte;response;Role;Sampling;Signaling Molecule;System;T cell response;T-Cell Activation;T-Lymphocyte;Testing;treatment response;tumor;Tumor Escape;tumor growth;tumor immunology;tumor progression;Tumor Promotion;Tumor-Derived;Tumor-infiltrating immune cells;uptake

PROJECT_TITLE: The Adenosinergic Pathway in Tumor-derived Exosomes

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ADMINISTERING_IC: ES

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: DAVIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE - Overall The UC Davis Environmental Health Sciences Center has, in its first four years, advanced understanding of various health conditions and the exposures that contribute to them. These include neurodevelopmental disorders, metabolic conditions like diabetes, and respiratory problems such as asthma. By learning what factors increase the risk or severity of these conditions, this research sets the stage for interventions that can prevent them, and thereby improve public health.

PI_NAMEs: HERTZ-PICCIOTTO, IRVA  (contact)

PROGRAM_OFFICER_NAME: THOMPSON, CLAUDIA L

PROJECT_TERMS: Academia;Acceleration;acceptability and feasibility;Achievement;Address;Adopted;Advisory Committees;Affect;Air;Air Pollution;Animals;Area;Asthma;behavior influence;Biochemical;Biological;Biological Assay;Biological Markers;Biological Models;Biological Sciences;biomarker identification;Biometry;California;career;Cell Culture Techniques;Chemicals;climate-related health;clinical care;Collaborations;college;Communities;Community Actions;Community Developments;community engagement;Complex;Country;design;Devices;Diabetes Mellitus;Dimensions;disability;Disease;Dose;Endocrine system;Engineering;Ensure;Environment;Environmental Exposure;Environmental Health;Environmental Impact;environmental justice;Environmental Pollution;Environmental Science;Epidemiology;epidemiology study;epigenomics;experimental study;exposed human population;exposure route;Faculty;Fostering;Functional disorder;Funding;Generations;Genetic;Genomics;Geography;Health;health equity;Health Professional;health science research;Health Sciences;Home;Human;Immune;Immune system;improved;in silico;In Vitro;Individual;Infrastructure;Integrative Medicine;interdisciplinary approach;interdisciplinary collaboration;Interdisciplinary Study;interest;International;Intervention;Knowledge;Leadership;Learning;Link;Malignant Neoplasms;Measurement;Medicine;member;Metabolic;metabolomics;Methods;Minority Women;Mission;Modeling;Molecular;Molecular Target;Monitor;National Institute of Environmental Health Sciences;Nervous System;Neurodevelopmental Disorder;new technology;novel;nutrition;Outcome;Pathway interactions;Patients;Physiological;Pilot Projects;Policies;Policy Maker;Population;portability;Predisposition;prevent;Process;programs;prototype;Public Health;Public Health Practice;Pump;Radar;recruit;Reproductive system;Research;Research Personnel;resilience;resilience factor;Resources;respiratory;Respiratory System;response;Risk;Schools;Science;Scientist;sensor;Severities;Social Conditions;Social Justice;social media;Strategic Planning;Strategic vision;Stress;success;synergism;Target Populations;Technology;technology development;Testing;Time;Toxic effect;Toxicokinetics;Training;transcriptomics;Translating;translational approach;translational framework;Translational Research;Translations;Underrepresented Minority;Veterinary Medicine;wearable device;Wildfire;Work;working group

PROJECT_TITLE: UC Davis Environmental Health Sciences Core Center

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS(P)]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Atherosclerosis;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Nutrition;Obesity;Prevention

ORG_CITY: LEXINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative Disruptions in biliary cholesterol secretion increases risk for chronic metabolic diseases including insulin resistance, nonalcoholic fatty liver disease, and atherosclerosis. This project investigates the mechanisms by which the G5G8 cholesterol transporter is regulated and opposes metabolic disease.

PI_NAMEs: GRAF, GREGORY A (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Ablation;absorption;adeno-associated viral vector;adenoviral mediated;Alanine Transaminase;Apical;Atherosclerosis;Bile Acids;Bile fluid;Biliary;Biological;cardiovascular risk factor;Cells;Cholesterol;cholesterol absorption;cholesterol transporters;Chronic;Clinical;Complex;Coupling;Data;Development;Diet;diet-induced obesity;dietary;Dietary Cholesterol;Disease;Enzymes;Equilibrium;Excretory function;experimental study;ezetimibe;Fatty acid glycerol esters;Fatty Liver;Fibroblast Growth Factor;Gall Bladder Diseases;Gallbladder;Gene Expression;glycemic control;Glycosylated hemoglobin A;Hepatic;Hepatobiliary;Hepatocyte;High Density Lipoproteins;Homeostasis;Human;improved;In Vitro;in vivo;Inflammation;inhibitor;Insulin Resistance;insulin sensitivity;Intestinal Hormones;Intestines;Investigation;Lipids;Liver;Lysosomes;Measures;Metabolic Diseases;metabolic phenotype;Metabolic syndrome;Modeling;Molecular;Mus;non-alcoholic fatty liver disease;novel;obesity development;Organ;Orthologous Gene;overexpression;Pathway interactions;Phenotype;Phospholipids;Physiological;Plasma;Post-Transcriptional Regulation;Post-Translational Regulation;Predisposition;prevent;Process;Proteins;Publishing;Reagent;Recombinant Proteins;Regulation;response;reverse cholesterol transport;Risk;Role;Signaling Molecule;Small Intestines;Sterols;Stimulus;Structure;Tissues;tool;transcriptome sequencing;Triglycerides;Variant

PROJECT_TITLE: Contributions of Hepatic and Intestinal Pathways to Cholesterol Excretion

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Social Determinants of Health

PROJECT_TERMS: Acceleration;Address;Administrator;Advisory Committees;Air Pollution;Applications Grants;Area;Award;California;career;career development;Center Core Grants;Child;Collaborations;Communication;Communities;community engagement;Community Outreach;Complement;Critiques;Decision Making;disability;Disasters;Disease;Disparate;Documentation;Educational workshop;Environment;Environmental Health;environmental justice;Epidemiology;Evaluation;Event;Faculty;Film;Fostering;Funding;Funding Agency;Goals;Government;Grant;Health;health science research;IACUC;improved;Incubators;Institutional Review Boards;interdisciplinary collaboration;interest;Intervention;Leadership;meetings;member;Mentors;Mission;National Institute of Environmental Health Sciences;news;operation;organizational structure;Outcome;outreach;Pilot Projects;Policies;Policy Maker;Preparation;Productivity;programs;Protocols documentation;Public Health;Public Health Practice;Publications;recruit;Research;research in practice;Research Infrastructure;Research Personnel;Resource Sharing;Resources;response;Science;Services;social media;Strategic Planning;Structure;Suggestion;Teacher Professional Development;Toxicology;Translations;Update;web site;Wildfire;Work;working group

PROJECT_TITLE: Administrative and Career Core

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS]


NIH_SPENDING_CATS: Bioengineering;Climate-Related Exposures and Conditions;Clinical Research;Prevention

PI_NAMEs: KENYON, NICHOLAS J. (contact)

PROJECT_TERMS: Affect;Agriculture;Animal Model;Animals;Applications Grants;Area;Award;base;biobank;Biological;Biological Assay;Biological Markers;Biological Sciences;Biology;Biometry;Biostatistical Methods;California;climate change;college;Communities;Consultations;Core Facility;Data;Data Collection;design;Development;disability;Disasters;Disease;Educational workshop;Environment;Environmental Exposure;Environmental Health;Environmental Risk Factor;Environmental Science;Epidemiology;epidemiology study;epigenomics;Extramural Activities;Fishes;Funding;Funding Opportunities;genome resource;Genomics;Goals;Grant;Health;health science research;Health Sciences;Human;Human Resources;human tissue;In Vitro;in vitro Assay;in vivo;innovation;Integrative Medicine;interdisciplinary collaboration;Intervention;Intervention Studies;Laboratories;Laboratory Animal Models;Leadership;Malignant Neoplasms;meetings;member;metabolomics;metabolomics resource;Methodology;Methods;model organism;Modeling;Molecular;Monitor;Mus;National Institute of Environmental Health Sciences;new technology;nonhuman primate;novel;Outcome;Physiologic Monitoring;Pilot Projects;Play;Population;population health;Population Research;Pre-Clinical Model;Preparation;Primates;programs;Public Health;Research;Research Design;Research Personnel;Research Project Grants;Resources;response;Rodent;Role;sample collection;Sample Size;Science;Scientist;sensor;sensor technology;Services;Smoke;Statistical Data Interpretation;success;Surveys;System;Technology;Time;tool;Translating;Translational Research;Veterinary Medicine;Veterinary Schools;wearable device;Wildfire;Work;Zebrafish

PROJECT_TITLE: Integrated Health Sciences Facility Core


NIH_SPENDING_CATS: Bioengineering;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: BENNETT, DEBORAH HALL (contact)

PROJECT_TERMS: Address;Air Pollutants;Animals;Applications Grants;Benchmarking;Biological;Biometry;Chemicals;Clinic;Collaborations;Communities;Complex;cost effective;Custom;Data;Data Analyses;design;Dust;Elements;Engineering;Ensure;Environment;Environmental Epidemiology;Environmental Health;environmental justice;environmental toxicology;Epidemiologist;Epidemiology;epidemiology study;exposed human population;exposure pathway;Exposure to;Faculty;Funding;Goals;Grant;Human Milk;Human Resources;improved;Inductively Coupled Plasma Mass Spectrometry;Inhalation Toxicology;interest;Isotopes;Laboratories;Leadership;Mass Spectrum Analysis;Measurement;meetings;member;method development;Methods;Modeling;multidisciplinary;particle;Persons;portability;Preparation;programs;recruit;Research;Research Design;Research Personnel;Resources;Sampling;Scientist;Source;Specific qualifier value;Spectroscopy, Fourier Transform Infrared;success;synergism;System;Techniques;Time;Tissues;Toxicology;Toxin;Wildfire;Work

PROJECT_TITLE: Exposure Core


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: LONDON, JONATHAN  (contact)

PROJECT_TERMS: Academy;Address;Advisory Committees;Agriculture;Area;Back;California;Collaborations;Committee Members;Communication;Communities;community building;community empowerment;community engaged research;community engagement;Community of Practice;community organizations;Community Outreach;community partners;community partnership;community research;Consultations;Core Facility;Country;design;Development;Educational workshop;effectiveness evaluation;efficacy evaluation;Ensure;Environmental Exposure;Environmental Health;Environmental Impact;environmental justice;Environmental Pollution;Equity;Evaluation;Event;Fostering;Foundations;Funding;Government Agencies;Health;health literacy;Health Professional;Health Promotion;Health protection;Health Sciences;improved;Individual;Industry;innovation;interest;Leadership;Learning;Logic;Measures;meetings;member;Modeling;Monitor;neighborhood disadvantage;Outcome;outreach;Peer Review;Pilot Projects;Policies;Policy Maker;Poverty;Process;Productivity;programs;Public Health;Publications;Reporting;Research;Research Personnel;Research Training;Risk;Scholarship;Science;Scientist;skills;success;Technology;Training;training opportunity;Translational Research;Translations;United States National Institutes of Health;Universities;Vertebral column;vulnerable community;Work;working group

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Clinical Research

PI_NAMEs: VAN WINKLE, LAURA S (contact)

PROJECT_TERMS: Address;Area;Attention;Award;base;Blood;Cardiovascular system;career;Categories;Clinic;Collection;Communities;community collaboration;community engaged research;community engagement;Complex;Core Facility;Data;Decision Making;design;Direct Costs;Discipline;Environmental Health;Epidemiology;Event;exhaust;Faculty;Fostering;Funding;Generations;Goals;Grant;Health;health science research;Human;Human Milk;innovation;Interdisciplinary Study;Investigation;Knowledge;Leadership;member;Methods;Mission;National Institute of Environmental Health Sciences;neighborhood disadvantage;Neuroimmune;Pilot Projects;Process;programs;Publications;Published Comment;recruit;Request for Proposals;Research;Research Personnel;Resource Development;Resources;respiratory;response;Spottings;Surveys;technological innovation;Technology;Testing;traffic-related air pollution;translational potential;Translational Research;United States National Institutes of Health

PROJECT_TITLE: Pilot Project Program


ADMINISTERING_IC: AR

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Cancer;Eye Disease and Disorders of Vision;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: Project Narrative Understanding epithelial stem cell regulation within tissues will serve to repair or replace cells or organs damaged by injury, disease, and aging. The strategies vary from generating cell types and tissues in a dish for transplantation purposes to directly stimulating the damaged organ in the living organism. This field has been exponentially growing for the past decade, and this conference will allow bringing together scientists from currently disparate areas, which will create synergy and result in faster progress in this field that is highly medically significant.

PI_NAMEs: KLEIN, OPHIR D (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Acceleration;Acute;Adult;Aging;Animals;appendage;Area;Asia;Australia;Biological Models;Biology;Biomedical Engineering;career;cell type;Cells;Clinic;Collaborations;Communication;comparative;Complex;Cornea;Country;craniofacial complex;Data;Development;Disease;disease model;Disparate;Education;Embryo;Environment;Epidermis;Epithelial Cells;epithelial stem cell;Epithelium;epithelium regeneration;Europe;Fertilization;field study;fighting;Floor;Fostering;Generations;Goals;graduate student;Growth;Homeostasis;Human;Image;in vivo;induced pluripotent stem cell;Injury;injury and repair;Institution;interest;Intestines;Life;Location;Lung;Malignant Neoplasms;Mammary gland;Medical;meetings;Metabolism;Mission;model organism;Molecular;Mus;news;next generation;Oral;Organ;Organism;Organoids;Participant;peer;Postdoctoral Fellow;posters;programs;Prostate;regenerative;Regenerative Medicine;Regulation;Regulatory Pathway;repaired;Research;Research Personnel;Rotation;Scientist;self-renewal;Signal Transduction;single cell analysis;Site;Skin;Source;Spain;stem;stem cell function;stem cell niche;Stem Cell Research;stem cells;Structure;Students;symposium;synergism;System;Techniques;Technology;three dimensional cell culture;Tissue Engineering;tissue stem cells;Tissues;Training;Transplantation;Veterans;Work

PROJECT_TITLE: 2024 Epithelial Stem Cells and Niches Gordon Research Conference and Seminar

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: RICHMOND

ORG_NAME: VA VETERANS ADMINISTRATION HOSPITAL

ORG_STATE: VA

PHR: The TBI literature provides preliminary evidence supporting associations between TBI exposures and poor health and functional outcomes, particularly as they occur in the context of the traumatic and stressful circumstances of military deployment. For this proposal, the researchers will work with and support the creation of a curated, unified dataset from LIMBIC and TRACTS prospective, longitudinal studies and demonstrate the feasibility of analytic approaches to detect for associations between objective, functional physiologic measures of TBI-related dysfunction, with clinically relevant outcome measures of TBI, including symptom burden and response to treatment. This proposed research will lay the foundations for the use of extant and ongoing prospective, longitudinal datasets and linked big datasets to generate generalizable, clinically relevant information on the role of objective, measurable assessments of brain function after TBI.

PI_NAMEs: CIFU, DAVID X. (contact)

PROJECT_TERMS: active duty;Address;Affect;Age;Area;associated symptom;Behavioral;Big Data;Biological Markers;Brain;Brain Diseases;Brain imaging;Brain Injuries;Caring;Center for Translational Science Activities;Characteristics;Clinical;clinical examination;clinical translation;clinically relevant;cohort;Collaborations;combat;computerized;Data;Data Analyses;Data Element;Data Set;demographics;Diagnostic;Electroencephalography;Epigenetic Process;Evoked Potentials;Factor Analysis;Foundations;Functional disorder;functional outcomes;Genetic;Health;High Prevalence;Human Resources;Individual;Injury;Knowledge;Link;Literature;Longitudinal cohort;Longitudinal cohort study;longitudinal dataset;longitudinal, prospective study;Machine Learning;Measurable;Measures;Mediator;Mental Depression;Mental Health;Military Personnel;military service;multimodal data;multimodality;neuroimaging;Neuropsychology;Outcome;Outcome Measure;Pain;Participant;Patients;physical conditioning;physical symptom;Physiological;Population;Post-Traumatic Stress Disorders;Predictive Factor;Prognosis;prospective;Quality of life;Questionnaires;Race;Reproducibility;Research;Research Personnel;Research Priority;research study;response;Risk;Risk Factors;risk stratification;Role;Saliva;Serum;service member;sex;Site;Source;Standardization;Statistical Methods;stress disorder;suicidal;Symptom Burden;symptom treatment;Symptoms;Testing;tool;Training;Traumatic Brain Injury;treatment response;Veterans;visual tracking;Work

PROJECT_TITLE: Total Brain Diagnostics (TBD): Analyzing the Impact of Physiologic Measures on Symptom Burden and Function Outcomes after TBI

STUDY_SECTION: RRDB

STUDY_SECTION_NAME: Brain Injury[RRDB]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: NEW HAVEN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The reduced efficacy of vaccines and monoclonal antibodies against SARS-CoV-2 variants of concern underscores the need for more universal antiviral approaches. I will investigate the structure and dynamics of highly conserved regions within Spike, the main target of neutralizing antibodies, and identify structural correlates of broadly reactive antibody Fc effector functions. This work will reveal key vulnerabilities of the Spike protein to inform the design of cross- reactive antibody therapies, Spike inhibitors, and vaccines.

PI_NAMEs: GRUNST, MICHAEL WILLIAM (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;ACE2;Affect;Angiotensin Receptor;Antibodies;Antibody Response;Antibody Therapy;antibody-dependent cell cytotoxicity;antigen binding;Antigens;Avidity;Binding;Cells;Cessation of life;combat;Complex;Coronavirus;cross reactivity;crosslink;Cryo-electron tomography;Data;design;Development;Epitopes;Event;Fc domain;Fc Receptor;Frequencies;Goals;Immune;immune function;immune resistance;Immunity;Immunoglobulin G;in silico;In Situ;Infection;inhibitor;insight;Mediating;Membrane;Membrane Fusion;Methods;Modeling;Molecular;Molecular Conformation;molecular dynamics;Monitor;Monoclonal Antibodies;Mutation;neutralizing antibody;novel;Patients;Peptides;Process;protein protein interaction;Proteins;receptor;receptor binding;recruit;Resistance;SARS-CoV-2 spike protein;SARS-CoV-2 variant;stem;Structure;Surface Antigens;Synapses;System;Temperature;Testing;universal vaccine;vaccine efficacy;vaccine-induced antibodies;Vaccines;Variant;variants of concern;Viral;viral fitness;viral resistance;Virion;Virus;Virus-like particle;Visualization;Work

PROJECT_TITLE: In situ structures of SARS-CoV-2 Spike fusion intermediates and Spike-antibody-Fc receptor complexes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-S (20)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Infant Mortality;Infectious Diseases;Lung;Pediatric;Pediatric - AIDS;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Vaccine Related;Women's Health Research

ORG_CITY: RONDEBOSCH

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF CAPE TOWN

PHR: PROJECT NARRATIVE HIV-exposed uninfected infants (iHEU) are disproportionately affected by GBS and RSV related illnesses owing partly due to lower maternal antibodies and impaired transplacental antibody transfer. Whether maternally acquired antibodies are functionally defective remains unknown. We therefore plan to test the hypothesis that iHEU acquire functionally defective antibodies that rapidly wane during infancy leaving them vulnerable to GBS and RSV illnesses.

PI_NAMEs: DZANIBE, SONWABILE  (contact)

PROGRAM_OFFICER_NAME: LORENZO, ERIC

PROJECT_TERMS: Accounting;Affect;Age Months;Antibodies;Antibody Avidity;Antibody titer measurement;antibody transfer;Antigens;Avidity;B-Lymphocytes;Birth;Blood;Cell Line;Cells;Cessation of life;clinical epidemiology;Clinical Trials;cohort;Collection;Communicable Diseases;Consensus;Data;Development;Disease;Enrollment;epidemiology study;Exposure to;Flow Cytometry;Fluorescent Dyes;Generations;high risk infant;HIV;HIV Infections;HIV-exposed uninfected infant;HL-60 Cells;Hospitalization;Human Milk;Immunity;Immunoassay;immunogenicity;Immunoglobulin A;Immunoglobulin G;Immunoglobulins;Immunologics;Impairment;Incidence;infancy;Infant;Infant Mortality;Infection;infection risk;Kinetics;Label;Licensing;Licensure;Life;Literature;Longevity;Longitudinal cohort;low and middle-income countries;Lower Respiratory Tract Infection;Maternal antibody;maternal vaccination;Measures;Methods;mortality;Mothers;nanoparticle;Neonatal Mortality;neonatal pneumonia;neonatal sepsis;neonate;neutralizing antibody;neutrophil;Newborn Infant;Passive Immunity;Pathway interactions;peripheral blood;Phagocytes;Phagocytosis;Phase III Clinical Trials;Placenta;placental transfer;Plasma;Polysaccharides;Population;Pregnant Women;Prevalence;prevent;Prospective cohort;Reporting;Respiratory syncytial virus;Respiratory syncytial virus RSV proteins;Respiratory Syncytial Virus Vaccines;Sampling;Standardization;Streptococcus Group B;Testing;Time;Umbilical Cord Blood;Vaccinated;vaccine efficacy;vaccine immunogenicity;vaccine-induced immunity;Vaccines;Viral Antigens;Virus Diseases;Vulnerable Populations;Woman

PROJECT_TITLE: Functional longevity of maternally derived antibodies against group B Streptococcus and respiratory syncytial virus in HIV-exposed uninfected and HIV-unexposed uninfected infants.

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-B (56)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative Among structural congenital heart defects (CHDs), abnormal valve development makes up the most common malformations, including defects in valve leaflet anatomy and function. While perturbations of retinoic acid (RA) signaling are associated with CHDs, little is known about the role of RA in vertebrate valve development. The results of this proposal will illuminate mechanisms underlying the requirements of RA in vertebrate valve development, which may provide insight into the causes of valve defects and may aid in the generation of novel strategies for the prevention, repair, and maintenance of valve diseases.

PI_NAMEs: FERNANDES, ANDREW THEODORE DAVID (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Adult;All-Trans-Retinol;Anatomy;Animal Model;Anterior;Automobile Driving;Blood coagulation;Cardiac;Cardiac Myocytes;Cardiac Surgery procedures;cardiogenesis;Cardiomegaly;Cell Proliferation;Child;Congenital Abnormality;Congenital Heart Defects;Consumption;CRISPR/Cas technology;Data;Defect;Development;Disease;Dominant-Negative Mutation;Embryo;Endocardial Cushion Defects;Endocardium;Endothelium;Etiology;Exhibits;expectation;Generations;genome editing;Heart Arrest;Heart Atrium;heart dimension/size;Heart failure;Heart Valves;Heat-Shock Response;Human;Hyperactivity;Infant Mortality;insight;Intake;Lateral;Life;Ligands;Maintenance;malformation;Mammals;Marketing;Mesenchymal;Mesoderm;Metabolic;Mitral Valve;Modeling;Mus;Myocardial;Myocardium;Newborn Infant;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Pattern;Population;prevent;Prevention strategy;Procedures;progenitor;repaired;Resources;restoration;Retinoic Acid Receptor;Role;semilunar valve;Signal Induction;Signal Transduction;Specific qualifier value;Stroke;Structural defect;Testing;Time;Transgenic Organisms;Tretinoin;valve replacement;Ventricular;vertebrate embryos;Vitamin A;WNT Signaling Pathway;Work;Zebrafish

PROJECT_TITLE: Effects of early Retinoic Acid signaling on valve development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-K (20)]


NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Infectious Diseases;Primary Immunodeficiencies;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: MADISON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Viral and bacterial infection and associated inflammation drive expansion and differentiation of hematopoietic stem and progenitor cells. These processes can be corrupted by germline genetic variation, which creates a predisposition to bone marrow failure through unknown mechanisms. We will develop systems and address mechanisms to understand how variation impacts infection/inflammation-instigated genetic networks. As fungal infection is common in patients with bone marrow failure and immunodeficiency, understanding the relationship between variation, infection, and hematopoiesis has critical fundamental and clinical/translational implications.

PI_NAMEs: BRESNICK, EMERY H (contact);SOUKUP, ALEXANDRA A

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Acute;Acute Myelocytic Leukemia;Address;Affect;Alleles;Aspergillus fumigatus;Attenuated;Bacterial Infections;Bar Codes;Bone marrow failure;bone marrow failure syndrome;Bone Marrow Transplantation;Cell surface;Cell Wall;chemokine;chemotherapy;Chronic;Clinical;Coupled;cytokine;cytopenia;Data Set;differential expression;Disease;Dysmyelopoietic Syndromes;Engineering;Enhancers;Epigenetic Process;epigenetic silencing;extracellular;Failure;Focus Groups;Foundations;galactosaminogalactan;GATA2 deficiency;Genes;Genetic;Genetic Models;Genetic Transcription;Genetic Variation;Germ Lines;Granulocyte Colony-Stimulating Factor;Hematopoiesis;Hematopoietic;hematopoietic differentiation;Hematopoietic Stem Cell Mobilization;Hematopoietic stem cells;Hematopoietic System;Heterozygote;Human;human model;immunodeficiency;Immunophenotyping;Impairment;Infection;Inflammation;Inflammatory;insight;Interleukin-8;Libraries;Mediating;mimetics;Modeling;mouse model;Mus;Mutation;Mycobacterium avium;Mycoses;Nucleotides;opportunistic pathogen;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Patients;peripheral blood;Pilot Projects;Polysaccharides;Population;Predisposition;prevent;Process;recurrent infection;Repression;response;RUNX1 gene;Signal Transduction;Single Nucleotide Polymorphism;single-cell RNA sequencing;stem cell biology;stem cell expansion;stem cell function;stem cell population;Sterility;Stimulus;Stress;Syndrome;System;Testing;Transcript;transcription factor;Transplantation;Variant;Viral;Virus Diseases;Wild Type Mouse

PROJECT_TITLE: Genetic Variation and Inflammation-Dependent Hematopoietic Regulatory Networks

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE  Age-dependent neurodegeneration is a major health and socioeconomic burden that will worsen as  human lifespan steadily increases. The mechanisms of degeneration initiation and progression, as well as protective pathways to combat disease, remain poorly understood. We propose to elucidate how proteins implicated in the polyglutamine family of degenerative diseases are regulated in intact animals and in human cells with the purpose of learning new ways to combat them therapeutically.

PI_NAMEs: TODI, SOKOL  (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Affect;age related neurodegeneration;Androgen Receptor;Animals;Autophagocytosis;Award;Biochemistry;Biology;Birds;Cell Physiology;Cells;Cellular biology;combat;comparative;Complement;Data;Degenerative Disorder;Dentatorubral-Pallidoluysian Atrophies;Dentatorubropallidoluysian atrophy pathway;Disease;disease model;Drosophila genus;Economic Burden;Environment;Experimental Designs;Eye;falls;Family;fly;Funding;Genetic;Genetic Screening;Genome;Goals;health economics;Human;human disease;Huntington Disease;improved;in vivo;Individual;Induced Neurons;innovation;insight;Intervention;Investigation;Kennedy Syndrome;knock-down;Learning;Length;Life Cycle Stages;life span;Link;Longevity;Mammalian Cell;Mass Spectrum Analysis;misfolded protein;MJD1 protein;Modeling;Molecular;Morphology;multicatalytic endopeptidase complex;Nerve Degeneration;Neurons;neuroprotection;neurotoxicity;novel;Organism;Paint;Pathology;Pathway interactions;Patients;Peptide Hydrolases;pharmacologic;Pharmacology;Physiological;Physiology;polyglutamine;polyglutamine neurodegenerative diseases;Population;premature;Process;protective pathway;protein aggregation;protein degradation;Protein Family;Proteins;Publishing;Quality Control;Recording of previous events;Reporting;Research;response;Role;Series;Site;socioeconomics;Spinocerebellar Ataxias;stem;Subcategory;Subgroup;System;Testing;Therapeutic;Toxic effect;Transgenes;Transgenic Animals;Transgenic Organisms;Type 1 Spinocerebellar Ataxia;Ubiquitin;ubiquitin isopeptidase;ubiquitin-protein ligase;Work

PROJECT_TITLE: MOLECULAR MECHANISMS OF NEUROPROTECTION IN POLYGLUTAMINE-DEPENDENT DEGENERATION

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-B (02)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Chronic Pain;Dental, Oral, and Craniofacial Disease;Pain Research;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_CITY: Newark

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PI_NAMEs: LIM, JOOHYUN  (contact)

PROGRAM_OFFICER_NAME: KRASNOVA, IRINA N

PROJECT_TERMS: Adult;Affect;Age Years;Biomechanics;bone;Cells;crosslink;Data;Defect;Deformity;Delaware;Development;Disease;FKBP10 gene;Heterotopic Ossification;High Prevalence;Homeostasis;Hydroxylation;Impairment;improved outcome;Individual;intervertebral disk degeneration;jaw movement;Knowledge;Length;Mandibular Condyle;Masseter Muscle;Medial;men;middle age;Mus;Musculoskeletal;National Institute of Dental and Craniofacial Research;Operative Surgical Procedures;Osteogenesis;Pain;Pathogenicity;pharmacologic;postnatal;prevent;Procollagen;Pterygoid Muscle;Research;Research Personnel;Research Proposals;Signal Transduction;stem cell population;stem cells;Temporomandibular Joint;Temporomandibular Joint Disorders;Tendon structure;Testing;Therapeutic Intervention;tissue injury;Tissues;transmission process;Treatment outcome;United States;United States National Institutes of Health;Width;Women's prevalence

PROJECT_TITLE: Mechanisms of heterotopic ossification in TMJ


NIH_SPENDING_CATS: Childhood Injury;Emergency Care;Pediatric;Physical Injury - Accidents and Adverse Effects

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Pediatric critical care and trauma physician-scientists discover knowledge that is vital for the health of children. The nation is facing a shortage of pediatric critical care and trauma physician-scientists. The goal of the PCCTSDP is to increase the number of diverse, well-trained, successfully funded physician-scientists in pediatric critical care and trauma surgery who are capable of sustaining careers in basic, clinical, translational and health services research that advance the understanding and care of critically ill and injured children and their families.

PI_NAMEs: KEENAN, HEATHER T. (contact);WATT, KEVIN M

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: Advisory Committees;Award;Basic Science;career development;Childhood;Childhood Injury;Clinical Management;Clinical Research;Committee Members;Competence;Critical Care;Critical Illness;Department chair;design;Development Plans;Educational workshop;Environment;Extramural Activities;Faculty;Family;Financial Support;Foundations;Functional disorder;Funding;Goals;Grant;Institution;Medicine;Mentored Clinical Scientist Development Program;Mentored Patient-Oriented Research Career Development Award;Mentors;pediatric trauma;Phase;Physicians;Program Development;programs;Reproducibility;Research;Research Personnel;Research Support;Research Training;Scientist;severe injury;skills;Surgeon;Teacher Professional Development;Time;Training;Translational Research;Trauma;trauma care;trauma surgery;United States National Institutes of Health;Work;Writing

PROJECT_TITLE: Pediatric Critical Care and Trauma Scientist Development Program (PCCTSDP)

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-N (55)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Fragile X syndrome (FXS), caused by loss of FMRP, is a common form of inherited intellectual disability and the leading monogenetic cause of autism. This research in a mouse model will identify a novel function for FMRP to regulate endocytic adapter proteins, which are essential for proper communication at synapses in the brain. This research will explore a potential new therapeutic strategy to correct for impairments in synapse plasticity and hyperexcitability in FXS.

PI_NAMEs: BASSELL, GARY J (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Adaptor Protein Complex 2;Adaptor Protein Complex Subunits;Adaptor Signaling Protein;Affect;AMPA Receptors;Area;autism spectrum disorder;Binding Proteins;Biology;Biotin;Brain;Brain Diseases;Clathrin Adaptors;Communication;Complex;Data;Defect;Development;Endocytosis;Epigenetic Process;FMR1 gene;Fragile X Syndrome;Future;Gene Silencing;Genetic;Glutamate Receptor;Goals;Impairment;Inherited;insight;Intellectual functioning disability;Ion Channel;Knowledge;Label;Mass Spectrum Analysis;Mediating;Membrane;Membrane Proteins;messenger ribonucleoprotein;Messenger RNA;Modeling;mouse model;mRNA Translation;Mus;neglect;Neurons;novel;novel therapeutic intervention;Pathway interactions;pharmacologic;Play;Post-Translational Protein Processing;posttranscriptional;Potassium Channel;Protein Biosynthesis;protein expression;protein protein interaction;Proteins;Proteome;Rare Diseases;receptor;Recycling;Regulation;Research;response;RNA;RNA-Binding Proteins;Role;Surface;Synapses;Synaptic plasticity;Testing;TFAP2A gene;therapeutic development;therapeutic target;trafficking;Translations;Trinucleotide Repeat Expansion;Work

PROJECT_TITLE: Fragile X messenger ribonucleoprotein-1 mediated regulation of the Clathrin-Associated Adaptor Complex Protein-2 (AP2)

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 RD-1 (01)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The malaria parasite exercises morphological changes to complete its life cycle. We identified a protein which associates with the parasite cytoskeleton in two life stages and is hypothesized to be essential for parasite replication. We aim to characterize its functional role in the blood stages of malaria infection and map its interactions to explore the parasite cytoskeleton and inform the rational design of antimalarial drugs.

PI_NAMEs: NAVARRO, FRANCESCA MARIA (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Address;Anopheles Genus;Anti-malarials;Apicomplexa;asexual;Biological Assay;Biotin;Biotinylation;Blood;Cell membrane;Cell Nucleus;Cell Shape;Cell Survival;Cessation of life;Complex;Culicidae;Cytoplasm;Cytoskeletal Proteins;Cytoskeleton;Data;Daughter;daughter cell;Development;Epitopes;Erythrocytes;Eukaryota;Excision;Exercise;experimental study;Family;Female;Flow Cytometry;Future;Genetic Materials;Hour;Human;Immunofluorescence Immunologic;Immunoprecipitation;Infection;interest;Intermediate Filaments;Invaded;Knock-out;Knowledge;Label;Laboratories;Life;Life Cycle Stages;Ligase;Malaria;malaria infection;male;Maps;Mass Spectrum Analysis;Membrane;Microscopy;Microtubule-Organizing Center;Microtubules;Molecular;Morphology;Motility;novel;Organelles;Parasites;Pathogenesis;Pathogenicity;Plasmodium;Plasmodium falciparum;Plus End of the Microtubule;Process;Proteins;rational design;Research;Role;Sampling;Sexual Transmission;Stains;Structure;Subcellular Spaces;superresolution imaging;Symptoms;System;Techniques;Testing;Tetanus Helper Peptide;Therapeutic;Transgenic Organisms;transmission blocking;Transmission Electron Microscopy;ultra high resolution;Western Blotting;Work

PROJECT_TITLE: Characterizing a novel Plasmodium cytoskeletal protein

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Electronic Nicotine Delivery Systems;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Switching to e-cigarettes is a harm-reducing alternative to combustible cigarettes for persistent smokers. Flavors may appeal to and aid these smokers unable to quit with traditional approaches. Yet, there are no prospective studies of the effect of flavor on initial and sustained switching from combustible cigarettes to e-cigarettes.

PI_NAMEs: AUDRAIN-MCGOVERN, JANET E (contact)

PROGRAM_OFFICER_NAME: REYES-GUZMAN, CAROLYN

PROJECT_TERMS: Adult;Advocate;Affect;Behavior;behavioral economics;Biochemical;Blueberries;Carcinogen exposure;Cessation of life;Cigarette;cigarette smoke;Cigarette Smoker;cigarette smoking;Clinical Research;Clinical Trials;Collection;combustible cigarette;design;Electronic cigarette;electronic cigarette use;epidemiology study;evidence base;Flavoring;follow-up;Fostering;Fruit;Harm Reduction;Health;interest;Investigation;Laboratories;Laboratory Research;Measures;Mediating;Menthol;Methods;Nicotine;nicotine replacement;nicotine reward;novel;Outcome Measure;Participant;Pharmaceutical Preparations;Phase;primary outcome;prolonged abstinence;prospective;Prospective Studies;Protocols documentation;Public Health;Randomized;Regimen;Regulation;reinforcer;Relapse;Reporting;Research;Rewards;Role;secondary endpoint;Smoke;Smoker;Smoking;smoking abstinence;smoking cessation;smoking exposure;Surgeon;Surveys;theories;Tobacco;tobacco flavor;Toxicant exposure;vaping;Visit;Watermelon

PROJECT_TITLE: The role of flavor in the substitutability of e-cigarettes for combustible cigarettes among persistent smokers

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric;Rare Diseases

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: PROJECT NARRATIVE ALX4 is a transcription factor that is important for proper bone, skull, and limb development, and mutations in ALX4 are associated with several different human birth defects that affect the development of the face, skull, and limbs. The overall goal of this proposal is to determine high-resolution structures of ALX4 and use biochemical/cellular assays to understand how ALX4 disease associated variants affect its function. Completion of these studies is important for understanding ALX4 function under normal physiological and pathophysiological contexts and will lay the groundwork for future studies to study ALX4 using in vivo models and initiate drug discovery projects focused on ALX4.

PI_NAMEs: KOVALL, RHETT ALLEN (contact)

PROGRAM_OFFICER_NAME: SHARMA, KARLIE ROXANNE

PROJECT_TERMS: Affect;Affinity;Alleles;Alopecia;Animal Model;Applications Grants;autosome;Base Pairing;Binding;Biochemical;Biological Assay;biophysical techniques;Biophysics;bone;Calorimetry;Cells;Cellular Assay;Congenital Abnormality;Craniosynostosis;cranium;Data;Defect;Development;dimer;Disease;Disease Progression;DNA;DNA Binding;DNA Binding Domain;drug discovery;Electrophoretic Mobility Shift Assay;Face;Frontonasal dysplasia;Future;Genetic Transcription;Goals;Grant;Hair;Head;Heterozygote;Homeobox;homeodomain;Human;Human Development;human disease;In Vitro;in vivo;in vivo Model;interdisciplinary approach;Knowledge;Limb Development;Limb structure;Luciferases;mammary;Maps;Mediating;milligram;Missense Mutation;monomer;mouse model;Mus;mutant;Mutation;nanomolar;Nose;Orbital separation excessive;Organoids;Parietal;Physiologic Ossification;Physiological;Pilot Projects;Polydactyly;Predisposition;premature;Property;protein function;Proteins;Reporter;Research;Resolution;Risk;Roentgen Rays;Role;screening;Site;small molecule;Structure;suture fusion;Testing;Titrations;tool;Tooth structure;transcription factor;Transcriptional Activation;Variant;X-Ray Crystallography

PROJECT_TITLE: Structure-function analysis of ALX4 disease alleles


ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: NARRATIVE  CAR-T cell therapy has shown astounding success in treating refractory or relapsed B cell malignancies, and is being explored as a promising immunotherapeutic agent against solid tumors as well as HIV, HCV and other public health relevant chronic viral infections with no efficacious vaccines or treatments available yet. Studies outlined in this proposal seek to address a key challenge in solid tumor CAR-T immunotherapy – homing and migration of adoptively transferred CAR-T therapeutic product to solid tumors. Leveraging bioengineering strategies that enhance chemoattractant expression by CAR-T cells in tumor sites, this proposal explores the possibility of transforming CAR-T cells into effector T cell beacons for enhanced therapeutic efficacy.

PI_NAMEs: SARKAR, SUROJIT  (contact)

PROGRAM_OFFICER_NAME: HARRIS, RAYMOND D

PROJECT_TERMS: Acute;Address;Adoptive Transfer;Antigen Receptors;Antigens;Antitumor Response;B lymphoid malignancy;Benchmarking;Biomedical Engineering;cancer infiltrating T cells;cancer therapy;Cancerous;CAR T cell therapy;Cell Count;chemokine;chemokine receptor;Chemotactic Factors;chimeric antigen receptor;chimeric antigen receptor T cells;Chronic;Clinic;Clinical;combat;Combination immunotherapy;Combined Modality Therapy;comparative efficacy;CXCL10 gene;CXCR3 gene;cytokine;Cytokine Receptors;cytotoxicity;Data;design;Development;Ectopic Expression;effector T cell;Engineering;Environment;exhaust;exhaustion;Exhibits;Future;Genetic;Half-Life;Hematologic Neoplasms;Hepatitis C virus;HIV;Homing;Immune;immune checkpoint blockade;Immunocompetent;Immunotherapeutic agent;Immunotherapy;inducible gene expression;Infiltration;Injections;Interferons;Intravenous infusion procedures;leukemia;Location;Macrophage;Malignant Neoplasms;Mediating;Memory;migration;Modification;mouse model;Mus;Natural Killer Cells;Neoplasm Metastasis;neoplastic cell;next generation;novel;Outcome;Penetration;Peripheral;Phenotype;pre-clinical;preclinical study;Production;programmed cell death protein 1;Property;Psychological reinforcement;Public Health;receptor;recruit;Refractory;Relapse;response;Response Elements;Rest;Signal Transduction;single-cell RNA sequencing;Site;Solid Neoplasm;stem;success;Survival Rate;synergism;systemic inflammatory response;T memory cell;T-Cell Homing Receptors;T-Cell Receptor;T-Cell Receptor Therapy;T-Lymphocyte;Therapeutic;Tissues;TNF gene;trafficking;Treatment Efficacy;treatment strategy;tumor;tumor microenvironment;Vaccines;Virus;Virus Diseases

PROJECT_TITLE: Designing inducible chemotactic beacons for enhanced trafficking of CAR T cells to solid tumors

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Adolescent Sexual Activity;Basic Behavioral and Social Science;Behavioral and Social Science;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Maternal Health;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health;Teenage Pregnancy;Women's Health Research

ORG_NAME: DREXEL UNIVERSITY

PHR: Project Narrative East and Southern African (ESA) countries have heavily invested in reducing HIV among adolescent girls by implementing social protection programs designed to promote safer sexual behavior and increase HIV testing. However, adolescent girls are not a monolithic population, and it is likely that marginalized sub-populations, like adolescent mothers, face social and economic barriers to participation which may limit their ability to engage in and benefit from social protection programs. This study will leverage publicly available, nationally representative data from the Population-based HIV Impact Assessment (PHIA) Projects across 8 African countries to understand whether adolescent mothers participate in social protection programs, which adolescent mothers participate in these programs, and which programs to prioritize to optimize impacts of HIV prevention initiatives for AMs across countries with high HIV-burden among girls.

PI_NAMEs: GROVES, ALLISON K. (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: 19 year old;Acceleration;Acquired Immunodeficiency Syndrome;Adolescent;adolescent HIV prevention;Adolescent HIV risk;Affect;Africa South of the Sahara;African;Age;AIDS prevention;Attention;behavior test;Birth;boys;Caring;Childbirth;Clinic;condoms;cost;Country;COVID-19 pandemic;Data;Data Analyses;Data Pooling;design;Economic Conditions;Economics;Education;Educational Subsidies;empowerment;Face;Female Adolescents;Funding;Gender;gender disparity;girls;Goals;HIV;HIV Infections;HIV risk;HIV-infected adolescents;Household;Human immunodeficiency virus test;Incidence;Individual Adjustment;Inequity;Investments;Lesotho;Malawi;marginalization;Marriage;meetings;Mentors;Modeling;motherhood;Mothers;Mozambique;Multiple Partners;Outcome;peer;Population;population based;Positioning Attribute;Pregnancy;pregnant;Prevalence;Program Development;programs;Reproductive History;Research;resilience;Risk;Role;Safe Sex;Services;sex;sexual risk behavior;sexual risk reduction;simulation;social;Social Conditions;Social Protection;social stigma;Southern Africa;statistics;Surveys;Tanzania;teenage mother;Uganda;Unmarried;Zambia;Zimbabwe

PROJECT_TITLE: Examining adolescent mothers' engagement in HIV prevention across high burden HIV countries in Sub Saharan Africa


NIH_SPENDING_CATS: Clinical Research;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Globally, 2.7 million children are living with HIV and over 90% of them live in sub-Saharan Africa where HIV subtypes A, C and D are predominant. In adults, HIV subtypes differ in virulence and transmissibility, but whether the same is true in children is unknown. The goal of this study is to determine the interplay of virologic and immunologic factors that slow disease progression in perinatal HIV and modulate the HIV reservoir size to stimulate innovative approaches towards HIV remission in children with perinatal HIV.

PI_NAMEs: KHAITAN, ALKA  (contact)

PROJECT_TERMS: 5 year old;Acute;Adult;Africa South of the Sahara;Age;Anti-Inflammatory Agents;antiretroviral therapy;biobank;Biological Markers;CD4 Lymphocyte Count;CD4 Positive T Lymphocytes;Cell Physiology;Cells;Child;Childhood;Clinical;cohort;Computer Models;cytokine;Data;Databases;Death Rate;Differential Equation;digital;disease classification;Disease Marker;Disease Progression;Disease remission;DNA;Enrollment;Enzyme-Linked Immunosorbent Assay;exhaust;Flow Cytometry;Future;Goals;HIV;HIV-1;HLA-DR Antigens;Immune;immune activation;Immunologic Factors;Immunologics;Individual;Infant;Infection;Inflammation;Inflammatory;innovation;Integration Host Factors;Interdisciplinary Study;Interleukin-6;Kenya;Knowledge;Life;Link;mathematical model;Mathematics;Measures;Mediator;meetings;Modeling;Multivariate Analysis;nonhuman primate;novel strategies;Outcome;Participant;pathogen;Pathogenesis;Patients;Pediatric cohort;pediatric human immunodeficiency virus;perinatal HIV;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Plasma;Population;predictive modeling;preservation;programmed cell death protein 1;Recommendation;Regulatory T-Lymphocyte;Reporting;Research;response;Role;Sampling;Shapes;SIV;South Africa;T cell response;T-Lymphocyte;Testing;Thailand;Vial device;Viral;viral fitness;Viral Load result;Viral reservoir;Viremia;Virulence;Virulence Factors;Virus Replication

PROJECT_TITLE: Virologic and Immunologic Correlates of Disease Progression in Perinatal HIV


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: PROJECT NARRATIVE Through continuation and enhancement of the Atlanta African American Maternal-Child Cohort, we will further leverage this unique environmental epidemiology cohort, our collaboration with a historically Black medical school, and our team’s expertise in exposure assessment, perinatal health, and omic sciences to advance environmental health science around predictive toxicology and individual susceptibility. We aim to expand: 1) enrollment and engagement in longitudinal follow-up of African American mother-child dyads through key windows of susceptibility (pregnancy through early childhood); 2) data collection to incorporate measures of environmental health equity (area-level measures of deprivation, segregation, air pollution) and environmental injustice (high-resolution metabolomics to identify bio-transformed metabolites linked with personal care product use); and 3) engagement with early stage investigators of the Morehouse School of Medicine NIEHS- supported Frontiers in Environmental Science and Health (FrESH) training program.

PI_NAMEs: DUNLOP, ANNE LANG (contact);JONES, DEAN PAUL

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: accelerated epigenetic aging;adverse birth outcomes;Affect;African American;African American Women;Air Pollution;Ancillary Study;Area;Awareness;Biological;Biological Markers;Black race;cardiometabolism;career;career development;Chemicals;Child;Child Health;cohort;Collaborations;Communities;community-level factor;Complex;Cultural Backgrounds;Data;Data Analyses;Data Collection;data sharing;deprivation;Development;Disease;Disparity;early childhood;early life exposure;early pregnancy;Emotional;Enrollment;Environmental Epidemiology;Environmental Exposure;Environmental Health;Environmental Science;Epidemiology;epigenome;Etiology;experience;Exposure to;Family;follow-up;Formulation;frontier;Health;health disparity;health equity;Health Personnel;in utero;Individual;Infrastructure;intergenerational;Investigation;Knowledge;Life Cycle Stages;Link;Maintenance;Measures;medical schools;member;Metabolic;Metabolic Biotransformation;metabolome;metabolomics;Methods;microbiome;minority investigator;Modeling;Morehouse School of Medicine;Mothers;National Institute of Environmental Health Sciences;Obesity;offspring;Outcome;Pediatric epidemiology;Perinatal;perinatal health;personal care products;Phenotype;population health;postnatal;Predisposition;Pregnancy;Pregnancy Complications;Premature Birth;prenatal;prenatal exposure;Preventive measure;psychosocial stressors;Research;Research Personnel;Research Support;Resolution;Resources;Risk;Role;Schools;Science;Scientist;segregation;Shapes;Small for Gestational Age Infant;Social Environment;social health determinants;Social Sciences;socioeconomics;Source;Stress;stressor;Structural Racism;toxicant;Toxicant exposure;Toxicology;Training Programs;Translations;Underrepresented Minority;United States;United States National Institutes of Health;Vulnerable Populations

PROJECT_TITLE: Maintenance and Enhancement of the Atlanta African American Maternal-Child Cohort

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LKB-D (U2)]


ORG_CITY: CHICAGO

ORG_DEPT: SURGERY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative The project aims to investigate the role of nonclassical monocytes in primary graft dysfunction (PGD) and injury in other organs following lung transplant. The project has two aims: to study how host classical monocytes promote the migration and retention of donor nonclassical monocytes in other organs, and to understand the opposing roles of donor and recipient nonclassical monocytes in PGD and remote organ injury. The insights gained will help develop new strategies to improve outcomes after lung transplant surgery.

PI_NAMEs: BHARAT, ANKIT  (contact);BUDINGER, GR SCOTT

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Affect;Anti-Inflammatory Agents;Cell surface;Cells;chemical release;Clinical Trials;Complex;Data;Development;Distant;Effector Cell;Endothelium;Epithelium;experience;experimental study;extracellular vesicles;fighting;Fractalkine;Functional disorder;Funding;Genetic Transcription;Goals;graft dysfunction;Immune;Impairment;improved outcome;Infection;Inflammatory;Injury;innovation;insight;intercellular communication;Ischemia;Kidney;Life;Lung;lung allograft;Lung Diseases;lung injury;Lung Transplantation;Mediating;Membrane;Messenger RNA;migration;Mitochondria;Molecular;monocyte;neutrophil;Neutrophil Infiltration;novel;novel therapeutic intervention;NR4A1 gene;Nuclear;Nucleotides;Organ;organ injury;pathogen;Pathway interactions;Patients;Persons;Phase;Pre-Clinical Model;prevent;Primary Prevention;Procedures;Publishing;Reactive Oxygen Species;recruit;Reperfusion Injury;Reperfusion Therapy;Research;Research Project Grants;Resolution;Role;Seminal;Severities;Signal Induction;Signal Pathway;Signal Transduction;success;Survival Rate;Therapeutic;therapeutic target;tissue injury;Tissues;TNF gene;Toll-like receptors;transcription factor;Transplant Recipients;Transplantation;Transplantation Surgery;Work

PROJECT_TITLE: Donor nonclassical monocytes mediate primary graft dysfunction and remote organ injury following lung transplant surgery

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE The voltage-gated ion channel CatSper is an exceptionally promising and validated target for male contraception because it is exclusively expressed in sperm, is critical for sperm function, and is required for male fertility. CatSper knock-out mice are completely infertile and naturally occurring CatSper mutations are a cause of male factor infertility in humans. We are developing compounds to inhibit CatSper and sperm function that can be used as male contraceptives.

PI_NAMEs: GEORG, GUNDA I. (contact)

PROGRAM_OFFICER_NAME: LINDSEY, CHRISTOPHER CHARLES

PROJECT_TERMS: absorption;Acrosome;Alkalinization;Binding Proteins;Biological Assay;Biological Availability;Calcium;CatSper;Cell membrane;Cells;Chemicals;Contraceptive methods;Data;Development;Drug Kinetics;druggable target;Effectiveness;efficacy study;egg;Epididymis;experimental study;female reproductive tract;Fertilization in Vitro;Goals;guanidinium;high throughput screening;Human;In Vitro;in vivo;Infertility;inhibitor;Investigational Drugs;Ion Channel;Ion Channel Gating;Ions;Knockout Mice;Lead;lead series;male;Male Contraceptive Agents;male fertility;Male Infertility;Maximum Tolerated Dose;Metabolic;Metabolism;Monitor;monolayer;Motility;Mus;Mutation;novel;Oral;Partner in relationship;Pathway interactions;Pattern;Permeability;pharmacologic;Phase;Pilot Projects;piperidine;Plasma;Potassium;pre-clinical;preclinical study;progenitor;Progesterone;Property;Quinolones;Research;Safety;scaffold;scale up;screening;Seminal fluid;Series;Solubility;Specificity;sperm cell;sperm function;Sperm Motility;Spermatocytes;Spermatogenesis;Sterility;Structure-Activity Relationship;Surface;Testing;Testis;Toxic effect;voltage

PROJECT_TITLE: Catsper Inhibitors for Male Contraception

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-Z (55)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Vector-Borne Diseases;West Nile Virus

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative Flaviviruses, including West Nile virus, remain pathogens of global health importance with limited therapeutic or vaccine interventions. Initiation of antiviral immunity is critical for clearance of viral infection and programming of adaptive immunity; however, we currently lack the understanding of types and localizations of viral RNAs that drive productive innate immune activation. This project aims to identify immunostimulatory viral RNA species that trigger RIG-I-like receptor mediated antiviral immunity during West Nile virus infection and define their localization and accessibility in the context of viral replication compartments and cytosolic pattern recognition receptors.

PI_NAMEs: GENOYER, EMMANUELLE  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: adaptive immunity;Anti-viral Response;antiviral immunity;Arbovirus Infections;Automobile Driving;Binding;Biochemical;Bioinformatics;Biological Assay;burden of illness;Cell Culture Techniques;Cells;Characteristics;combat;Confocal Microscopy;Coupled;crosslink;Cryo-electron tomography;Data;Detection;Disease;Electron Microscopy;emerging pathogen;Event;Family;first responder;Flavivirus;Flavivirus Infections;Fluorescence;Fluorescent in Situ Hybridization;functional genomics;Generations;Genes;Genomics;Germ Lines;global health;Heterogeneity;high resolution imaging;Imaging Techniques;Immune;immune activation;Immune response;Immune signaling;Immunofluorescence Immunologic;Immunoprecipitation;Incidence;Individual;Infection;Innate Immune Response;innovation;Interferon Activation;Interferons;Intervention;Ligation;light microscopy;Location;Maps;Mediating;Membrane;Modeling;Molecular;Natural Immunity;Nature;neurotropic;next generation;novel;Nuclear Translocation;Nucleotides;pathogen;pathogenic virus;Pattern;Pattern recognition receptor;Process;Production;Productivity;Property;Proteins;receptor;Receptor Signaling;Regulation;Research;Research Personnel;Resolution;response;RNA;RNA Binding;RNA replication;Role;sensor;Signal Pathway;Signal Transduction;Site;Sorting;spatial relationship;System;Techniques;Therapeutic;Training;transcription factor;transcriptome sequencing;United States;Vaccines;Vesicle;Viral;viral detection;Viral Genome;viral RNA;virology;Virus;Virus Diseases;virus genetics;Virus Receptors;Virus Replication;Visualization;West Nile viral infection;West Nile virus;Work

PROJECT_TITLE: Identity and Accessibility of Immunostimulatory Viral RNAs During Flavivirus Infection


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Genetics;Maternal Health;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: SAN ANTONIO

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

ORG_STATE: TX

PHR: PROJECT NARRATIVE A significant unmet need for worldwide population control exists due to the lack of available safe, effective, and reversible oral male contraceptives. To close this critical translational gap, we propose to target the testis-specific RNA binding protein RBM46 as a contraceptive approach. The overarching goals of this project are to screen for small molecules that bind RBM46, develop these “binders” into proteolysis targeting chimeras (PROTACs) to specifically degrade RBM46 protein in differentiating spermatogonia, and then determine whether use of these PROTACS induces reversible male sterility in both mice and marmosets, a non-human primate model with closer similarity to humans.

PI_NAMEs: GEYER, CHRISTOPHER BENNETT;HERMANN, BRIAN PETER (contact);YUAN, YAXIA

PROJECT_TERMS: abortion;Address;Adult;Affinity;analog;Basement membrane;Binding;Binding Sites;Biological Assay;Biological Availability;Blood-Testis Barrier;Breeding;Callithrix;cell type;Cells;Characteristics;Chemical Structure;chemical synthesis;Chemicals;Childbirth;Clinic;commercialization;Computer Assisted;Computer software;Contraceptive Agents;contraceptive effectiveness;contraceptive efficacy;Contraceptive methods;contraceptive target;cost effective;design;Development;Dose;Drug Design;drug development;drug discovery;Drug Kinetics;Drug Screening;Drug Targeting;drug-like compound;efficacy study;elective abortion;experience;Fluorescence Polarization;fly;Future;Genomics;Germ Cells;Germ Lines;Goals;Health;high risk;high throughput screening;Human;In Vitro;in vivo;Infertility;interest;Investigation;Investigational Drugs;Kinetics;Knockout Mice;Lead;Libraries;Ligand Binding;Ligands;male;Male Contraceptive Agents;Male Infertility;Male Sterility;Maternal Mortality;Maximum Tolerated Dose;Meiosis;Messenger RNA;Mission;Modeling;Monkeys;Mus;Mutation;National Institute of Child Health and Human Development;nonhuman primate;Normalcy;novel;novel strategies;Oral;Orthologous Gene;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phase;Phenotype;Population Control;Positioning Attribute;pre-clinical;Pregnancy;Primates;progenitor;Protac;Proteins;Publishing;Recombinants;Reproduction;Research;RNA-Binding Proteins;Safety;scaffold;screening;Seminiferous tubule structure;single cell genomics;single-cell RNA sequencing;small molecule;small molecule inhibitor;sperm cell;Spermatids;Spermatocytes;Spermatogenesis;Spermatogenic Cell;Spermatogonia;Stem cell transplant;stem cells;Sterility;Structure-Activity Relationship;success;Surface Plasmon Resonance;Testis;Toxic effect;Transplantation;Undifferentiated;unintended pregnancy;United States National Institutes of Health;virtual screening;Woman

PROJECT_TITLE: Development of small molecule inhibitors of RBM46 as novel male contraceptives


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Parent Application Project Narrative There are no approved drugs targeting pre-mRNA splicing in cancer. We have discovered a new class of small molecule drugs that target pre-mRNA splicing. Our proposed studies, which aim to understand their mechanism of action, will catalyze their development into a new class of cancer therapy.

PI_NAMEs: NIJHAWAN, DEEPAK  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Alleles;anti-cancer;anticancer activity;Binding;Biology;cancer cell;Cancer Cell Growth;cancer therapy;Cause of Death;Cell Death;cell growth;Cells;cellular targeting;Chloroquinoxaline Sulfonamide;clinical development;Complex;Critical Pathways;Cullin Proteins;Data;Defect;Development;Drug Targeting;Exons;experimental study;FDA approved;Functional dependence;Gene Expression;Genes;genome-wide analysis;Goals;Human;human model;immune modulating agents;inhibitor;Introns;Knowledge;lenalidomide;Libraries;Ligase;Malignant Neoplasms;member;mRNA Precursor;Mutation;new therapeutic target;novel therapeutics;Oncogenic;Parents;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;pleiotropism;Pre-Clinical Model;programs;Protein Family;Proteins;Publishing;receptor;recruit;Research;Resistance;resistance mutation;RNA Binding;RNA Splicing;small molecule;Sulfonamides;Testing;Thalidomide;tumor;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;United States;Work

PROJECT_TITLE: Understanding the mechanism of action for anticancer sulfonamides that target splicing


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Rehabilitation

ORG_CITY: GAINESVILLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative  This project seeks to help people with severe essential tremor improve their therapy through advanced closed loop medical device technology. These studies will make important contributions to the public health because it builds on rapid advances in technology to give subjects better treatment of a common illness, essential tremor. It will also help improve our understanding of how the brain perceives and controls limb movement so we can provide better clinical solutions to the affected subjects. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

PI_NAMEs: FOOTE, KELLY D;OWEISS, KARIM G (contact)

PROGRAM_OFFICER_NAME: ROBINSON SCHWARTZ, SARAH ELIZABETH

PROJECT_TERMS: Activities of Daily Living;Address;Adverse effects;Affect;Algorithm Design;Algorithms;Anterior;arm function;arm movement;battery life;Biological Markers;Brain;Cerebellum;Chronic;Clinical;clinical application;Data;Deep Brain Stimulation;Development;disability;Disparate;Dysarthria;effective therapy;effectiveness evaluation;efficacy evaluation;Engineering;Essential Tremor;experience;Failure;Feasibility Studies;Feedback;flexibility;Functional disorder;functional restoration;Globus Pallidus;Goals;Human;human subject;Hybrids;Impairment;Implant;improved;industry partner;Intention Tremor;Knowledge;Lead;limb movement;Medical Device;Microelectrodes;migration;Modeling;Motor;Motor Cortex;Movement;Multiple Sclerosis;multiple sclerosis patient;neural;neural circuit;neural network;neurophysiology;neuroregulation;Neurosciences;Operative Surgical Procedures;Parkinson Disease;Pathologic;Patients;Persons;Population;Progressive Disease;Public Health;Quality of life;receptor;Refractory;Research Personnel;Safety;Second Look Surgery;Severities;side effect;Signal Transduction;Solid;Spinal cord injury;Stroke;Structure;symposium;System;Techniques;Technology;Thalamic Nuclei;Thalamic structure;Therapeutic;Time;Titrations;Tremor;Upper limb movement;Use Effectiveness;Work

PROJECT_TITLE: Dual Lead Thalamic DBR-DBS Interface for Closed Loop Control of Severe Essential Tremor


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Epilepsy;Neurodegenerative;Neurosciences;Pediatric

ORG_CITY: STANFORD

ORG_DEPT: NEUROLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Children with benign epilepsy with centrotemporal spikes (BECTS), the most common pediatric epilepsy syndrome, have a mild seizure disorder but yet have moderate difficulties with language that impact their quality of life more than the seizures. Separate from the seizures, these children have frequent abnormal activity in their brain known as interictal epileptiform discharges (IEDs), which we currently do not treat. This project uses a form of non-invasive brain stimulation (called transcranial magnetic stimulation) to determine the impact of IEDs on brain regions important for language in order to investigate: (1) if treatment of IEDs could improve language; and (2) if brain stimulation may be a novel treatment option.

PI_NAMEs: BAUMER, FIONA MITCHELL (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Acute;Age;Area;Attention;Automobile Driving;Award;Benign;Biological;Blood flow;Brain;Brain region;Cephalic;Child;Childhood;childhood epilepsy;Clinical Research;clinical training;clinically significant;Cognition;Cognitive;comorbidity;comparison control;Complement;Coupled;Cross-Sectional Studies;Data;density;design;Development;Electroencephalography;Epilepsy;epileptiform;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;Future;Generations;Goals;Handedness;improved;Inferior frontal gyrus;innovation;International;Knowledge;Laboratories;Language;Language Development;Language Disorders;language processing;Left;Link;magnetic field;Maps;Measurement;Mentors;Mentorship;Methodology;Methods;minimally invasive;Motor;Motor Cortex;neurodevelopment;Neurologic;Neurosciences;noninvasive brain stimulation;novel;Pathologic;patient oriented research;Patients;Perception;Performance;Pharmaceutical Preparations;Physicians;Population;Positioning Attribute;programs;Quality of life;recruit;Reporting;Research;Research Personnel;response;Rotation;Scientist;Seizures;Sleep;Specificity;Standardization;Superior temporal gyrus;Syndrome;Testing;Therapeutic;Training;Transcranial magnetic stimulation;Universities;Wakefulness;Work

PROJECT_TITLE: Speaking of Spikes: Connectivity and Language in Benign Epilepsy with Centrotemporal Spikes

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Genetics;Orphan Drug;Pancreatic Cancer;Precision Medicine;Rare Diseases

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: Narrative: Mutant KRAS protein drives several cancer related pathways and remains a highly sought after target. We have discovered that targeting nuclear transporter XPO1 by specific inhibitors of nuclear export drugs can synergize with KRAS targeted drugs. We will perform critical pre-clinical analysis of this synergy to bring forward a novel and effective combination therapy targeting the KRAS and nuclear protein transport axis in oncogenic RAS driven tumors.

PI_NAMEs: AZMI, ASFAR S (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: analog;Binding Proteins;Biological;biomarker development;biomarker identification;Cell model;Cell Nucleus;Cells;Clinical;clinical translation;Combined Modality Therapy;Computational Biology;Correlative Study;Coupled;CRISPR/Cas technology;Critical Pathways;Data;Desmoplastic;Disease;Drug Targeting;epithelial to mesenchymal transition;experimental study;exportin 1 protein;Expression Profiling;FBXW7 gene;Fibroblasts;gemcitabine;Genes;genome editing;Global Change;Grant;Growth;improved;in vivo;inhibitor;innovation;Investigation;Karyopherins;Knowledge;KPC model;KRAS2 gene;KRASG12D;Link;Maintenance;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Mediator;MEKs;Methodology;Modeling;mouse model;mutant;Mutation;new therapeutic target;Non-Small-Cell Lung Carcinoma;Normal Cell;novel;novel therapeutic intervention;novel therapeutics;Nuclear;Nuclear Export;Nuclear Protein;nucleocytoplasmic transport;objective response rate;Oncogenic;Oral Administration;Organoids;Outcome;overexpression;Paclitaxel;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pathway Analysis;Pathway interactions;patient derived xenograft model;Patient Recruitments;patient subsets;Patients;Penetrance;Peptide Signal Sequences;personalized medicine;Pharmaceutical Preparations;pharmacodynamic biomarker;Phase;Phase Ib/II Clinical Trial;Phase Ib/II Trial;Phosphorylation;pre-clinical;preclinical study;Process;Proliferating;Protein Export Pathway;Protein Family;protein transport;Proteins;RAS driven tumor;Ras/Raf;Recruitment Activity;Regimen;Reporting;Residual Neoplasm;Resistance;resistance mechanism;response;response biomarker;RNA Interference;Role;Running;Safety;Signal Transduction;Specificity;Specimen;stemness;subcutaneous;success;synergism;targeted treatment;therapy design;therapy outcome;therapy resistant;transcriptome sequencing;Transgenic Organisms;treatment response;tumor;Tumor Suppressor Proteins;Vascularization;Work

PROJECT_TITLE: Clinical Translation of Nuclear Export Inhibitor in Metastatic Pancreatic Cancer


ORG_CITY: NEW YORK

ORG_NAME: ROCKEFELLER UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative This study will identify target genes and mechanisms of action of a B cell-specific transcriptional co-activator (OCA-B) that has been demonstrated to be essential for germinal center (GC) formation and implicated in GC- derived lymphomas. This study will advance our understanding of humoral immune responses and provide insights into the development of new therapeutic strategies for immune deficiencies, autoimmune diseases and lymphomas.

PI_NAMEs: ROEDER, ROBERT G (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Adaptive Immune System;Address;Affinity;Anatomy;Antibodies;Antigens;Autoimmune Diseases;Autoimmunity;B cell differentiation;B-Cell Development;B-Cell Lymphomas;B-Lymphocytes;BCL6 gene;Binding;Biochemical;Bioinformatics;Biological Assay;Burkitt Lymphoma;C-terminal;candidate identification;Cell Culture System;cell growth;Cell Line;Cell Maturation;Cell Proliferation;Cells;Chromatin;Clonal Expansion;cofactor;Complex;Data;Defect;Dependence;Development;Disease;Distal;DNA;Drug Targeting;Enhancers;Epigenetic Process;Gene Activation;Genes;Genetic;genetic approach;Genetic Transcription;Genomic approach;Genomics;Goals;Health;Hematopoietic stem cells;Human;imaging approach;Immune response;Immune system;immunodeficiency;Immunoglobulin Genes;Immunoglobulin Somatic Hypermutation;Immunoglobulin-Secreting Cells;Immunologic Stimulation;Immunotherapy;Impairment;In Vitro;in vivo;insight;Knockout Mice;large cell Diffuse non-Hodgkin's lymphoma;Locus Control Region;Lymphoid;Lymphoma;Lymphoma cell;Lymphomagenesis;Malignant Neoplasms;Mediating;Mediator;Memory B-Lymphocyte;Microanatomy;Molecular Mechanisms of Action;mouse model;Mutation;neoplastic cell;novel therapeutic intervention;Oncogenic;Pathway interactions;Physical condensation;Play;Process;programs;promoter;Proteomics;Recombinants;reconstitution;recruit;Recurrence;Reporter;Reporting;response;Response Elements;Role;secondary lymphoid organ;Series;Signal Pathway;Site;Specific qualifier value;Structure of germinal center of lymph node;System;Time;Transcription Coactivator;transcription factor;Transcriptional Regulation

PROJECT_TITLE: Functions and mechanisms of transcriptional coactivator OCA-B in B cell development and lymphomagenesis

STUDY_SECTION: MGA

STUDY_SECTION_NAME: Molecular Genetics A Study Section[MGA]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Mental Health;Neurosciences;Rehabilitation

PHR: PROJECT NARRATIVE Although gastroesophageal reflux disease (GERD) is a common medical condition affecting at least 10-20% of the adult US population, it is poorly understood in terms of the mechanisms causing reflux and how symptoms are triggered by reflux. This proposal will attempt to develop a better understanding of the complex interaction of the brain-gut connection in promoting reflux symptoms by performing clinical trials using behavioral therapies to improve symptoms in GERD. This project will also enable us to develop a better understanding of how psychological distress can impact gastrointestinal diseases as we will study how changes in stress affect symptoms in patients with the same physiology.

PI_NAMEs: PANDOLFINO, JOHN E (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Acids;Adult;Affect;Arousal;Automobile Driving;Autonomic nervous system;Behavior assessment;Behavior Therapy;Clinical;Clinical Data;Clinical Trials;Cognitive Therapy;comparative effectiveness trial;Complex;cost;Counseling;Data;design;Development;Direct Costs;Disease;Disease Management;Disease Outcome;effectiveness evaluation;efficacy trial;electric impedance;Endoscopy;Esophagus;Event;experimental study;Facilities and Administrative Costs;Funding;Gastroenterology;Gastroesophageal reflux disease;Gastrointestinal Diseases;Goals;gut-brain axis;health care service utilization;Healthcare;heart rate variability;Heartburn;Hour;Hypersensitivity;improved;improved outcome;indexing;Intervention;Life Style;Manometry;Measures;Medical;Modeling;Mucous Membrane;new therapeutic target;Outcome;outcome prediction;Outcome Study;Pathogenesis;Pathologic;Patient-Focused Outcomes;Patients;Perception;Permeability;Phenotype;Physicians;Physiological;Physiology;Population;Process;Provider;psychological distress;psychological stressor;Psychology;Psychophysiology;Quality of life;Randomized;Randomized, Controlled Trials;Reflux;Refractory;Research Design;Resolution;response;Severities;Severity of illness;standard of care;stem;Stress;stressor;symptomatic improvement;Symptoms;Testing;theories;Visceral;Widespread Disease;Work

PROJECT_TITLE: Targeting Hypervigilance and Autonomic Arousal: the Psycho-physiologic Model of GERD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DNPD-A(01)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: IOWA CITY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Memory impairment is a core deficit accompanying many neurological disorders. This proposal will examine how compartmentalized plasticity modulates learning and memory, from the molecular through the circuit levels. These experiments will add to the knowledge base required for rational design of treatments for memory disorders.

PI_NAMEs: TOMCHIK, SETH M (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Acetylcholine;Afferent Neurons;Anatomy;Association Learning;Automobile Driving;Axon;Behavior;Behavioral;behavioral response;Brain;Brain Diseases;Butyrates;Cell Physiology;Cells;Cyclic AMP;Data;Decision Making;Development;Dissociation;Drosophila genus;Drosophila melanogaster;Endoplasmic Reticulum;Event;experience;experimental study;flexibility;fly;Genomics;Goals;Image;in vivo imaging;Individual;insight;Investigation;knowledge base;Learning;Mammals;Mediating;Memory;Memory Disorders;memory encoding;Memory impairment;model organism;Modeling;Molecular;Molecular Biology;Mushroom Bodies;Mutation;Nervous System;Nervous System Disorder;neuronal circuitry;Neurons;Neurosciences Research;neurotransmitter release;novel;Odors;Olfactory Learning;Output;Pathway interactions;Pattern;postsynaptic;presynaptic;Process;rational design;Reporter;Resolution;response;Retrieval;Rewards;RNA Interference;Role;Route;sensor;Sensory;sensory stimulus;Signal Transduction;Stimulus;Sucrose;Synapses;synaptic function;Synaptic plasticity;System;Testing;therapy design

PROJECT_TITLE: Mechanisms of compartmentalized plasticity in learning and memory

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Genetics

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Defects in chromatin organization, gene transcription, and DNA packaging are major causes of human disease, notably cancer. Our studies will uncover the functions of readers and writers of histone post-translational modifications and histone variants, as well as the function of a histone chaperone complex. These studies will advance our fundamental understanding of the chromatin regulators that are dysregulated in human disease, thereby identifying new targets for therapeutic intervention.

PI_NAMEs: STRAHL, BRIAN D (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Address;Award;Binding;Biology;Chromatin;Complex;Defect;DNA Packaging;Enzymes;Event;Genetic Transcription;Genome;Goals;Histones;human disease;Knowledge;Malignant Neoplasms;Modification;Molecular;Molecular Chaperones;new therapeutic target;Nucleosomes;Post-Translational Protein Processing;Proteins;Reader;Regulation;Research Design;Therapeutic Intervention;Transcriptional Regulation;Variant

PROJECT_TITLE: Mechanisms of chromatin and transcriptional regulation

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Genetics;Neurosciences;Pediatric

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: Several neurological diseases are characterized by defects in protein homeostasis within the endoplasmic reticulum (ER) and secretory pathway. The long-term objective of this proposal is to study (i) how ATase1, ATase2 and GDAC collaborate to ensure essential neuronal functions, and (ii) how this collaboration is lost in neurological disorders. The ultimate goal is to explore therapeutic strategies with the potential to define new avenues of research (and treatment) for different neurological diseases.

PI_NAMEs: PUGLIELLI, LUIGI  (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Acetyl Coenzyme A;Acetylation;Acetyltransferase;Animals;autism spectrum disorder;Autophagocytosis;Biochemical;Biological Process;Biology;Brain;Cellular biology;Cessation of life;Collaborations;Communication;Deacetylase;Defect;design;Developmental Delay Disorders;disease phenotype;Endoplasmic Reticulum;Ensure;Equilibrium;Event;experimental study;Functional disorder;Gene Duplication;Genetic;Glutamate-ammonia-ligase adenylyltransferase;Glycoproteins;Goals;Golgi Apparatus;Heterozygote;Human;human disease;in vivo;Intellectual functioning disability;Laboratories;loss of function;Lysine;Maintenance;Mass Spectrum Analysis;Mediating;Membrane Transport Proteins;Metabolic;Modeling;Molecular;Molecular Biology;mouse model;Mus;Mutation;Nervous System Disorder;Neurons;Neuropathy;novel;Organelles;Output;Pathway interactions;Peripheral;pharmacologic;Phenotype;premature;Progeria;protein aggregation;Proteins;proteostasis;Quality Control;Research;response;Series;Techniques;Testing;Therapeutic;trafficking;translational approach

PROJECT_TITLE: ATase1 and ATase2, proteostasis, and neurological diseases

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetic Testing;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Prevention;Rare Diseases

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Project Narrative: Splenic marginal zone lymphoma is the most common form of cancer arising in the spleen. Current diagnosis is based on histopathologic criteria and requires splenectomy despite the fact that virtually all cases involve peripheral blood. We and others have recently determined the genomic aberrations that characterize this disease and propose to employ state–of-the-art and sensitive genomic sequencing approaches to achieve early and accurate disease diagnosis. The studies in this proposal will lead to development of simple blood-based assays that will improve early detection and promote implementation of early and appropriate treatment.

PI_NAMEs: ELENITOBA-JOHNSON, KOJO S. J. (contact)

PROGRAM_OFFICER_NAME: HODGES, NICHOLAS AARON

PROJECT_TERMS: accurate diagnosis;Address;B-Lymphocytes;Biologic Characteristic;Biological;Biological Assay;Biological Markers;Blinded;Blood;Blood specimen;Bone Marrow;Bone Marrow Involvement;Categories;Characteristics;Clinical;clinical diagnosis;Clonality;cohort;Detection;Development;Diagnosis;diagnostic accuracy;Disease;disease diagnosis;DNA Sequence Alteration;early detection biomarkers;Early Diagnosis;exome sequencing;Future;Gene Mutation;Genes;genome sequencing;genomic aberrations;genomic biomarker;Genomics;Goals;High-Throughput Nucleotide Sequencing;Immunoglobulin Gene Rearrangement;Immunoglobulin Genes;immunohistochemical markers;improved;Lymphoma;Malignant Neoplasms;Modeling;Monitor;Mutate;Mutation;Mutation Analysis;Mutation Detection;novel;Operative Surgical Procedures;Patients;Performance;peripheral blood;Peripheral Blood Involvement;Peripheral Blood Mononuclear Cell;Population;prospective;Prospective cohort;Recurrence;Reproducibility;Research;Residual Neoplasm;Retrospective cohort;Risk;Sampling;Spleen;Splenectomy;Splenic Tissue;Techniques;Testing;Tissues;Training;Tumor Tissue;virtual;whole genome

PROJECT_TITLE: Genomic biomarkers of splenic lymphoma

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Maternal Health;Pregnancy;Women's Health Research

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative We will test whether (i) exogenous melatonin during the day increases the number of uterine contractions in full- term pregnant women, (ii) exogenous melatonin can increase light-exposure associated suppression of uterine contractions at night in late-term pregnant women, and (iii) there is a relationship between circulating melatonin levels and number of uterine contractions. The findings in this research project will contribute vital information to our understanding of the causal role of melatonin in changing the number of uterine contractions, and may have important clinical implications.

PI_NAMEs: KLERMAN, ELIZABETH B. (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: Affect;Agonist;antagonist;Binding;Birth;circadian;Clinical;cost;Data;design;Discipline of obstetrics;Dose;Double-Blind Method;Double-blind trial;experimental study;Exposure to;Goals;Home;Hormones;Hospitalization;Hospitals;Hour;Human;improved;In Vitro;in vitro Model;Individual;Inpatients;Intervention;Light;Lighting;Measures;Melatonin;Melatonin Receptors;Midwifery;Monitor;mRNA Expression;Muscle Contraction;myometrium;Neurosecretory Systems;obstetric care;Participant;Pharmacologic Substance;Phototherapy;Physiological;pill;Pilot Projects;Placebos;Pregnancy;Pregnant Uterus;Pregnant Women;protein expression;Protocols documentation;Randomized;reproductive;Research Project Grants;Resources;Risk;Role;Seasons;Testing;therapy design;Up-Regulation;uterine contractility;Uterine Contraction;Variant;Woman;Work

PROJECT_TITLE: Testing Effects of Melatonin on Uterine Contractions in Women

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Aging;Clinical Research;Digestive Diseases;Estrogen;Menopause;Nutrition;Obesity;Prevention;Women's Health Research

PHR: Project Narrative Diverticulitis is a poorly studied but common and costly gastrointestinal disease with no definitive cure or identified means of prevention. Determining the factors driving the association between obesity and diverticulitis risk will ultimately allow for new approaches to the prevention and treatment of diverticulitis.

PI_NAMEs: PEERY, ANNE  (contact)

PROJECT_TERMS: abdominal fat;Address;Adipocytes;adipokines;adiponectin;Adipose tissue;Age;APLN gene;Archives;Automobile Driving;Behavioral;Biological;Biological Markers;Biology;Blood specimen;burden of illness;cardiovascular risk factor;Central obesity;Characteristics;cohort;Colon;cost;cytokine;Data;Data Collection;data standards;Development;Disease;Disparity;Diverticulitis;Dyslipidemias;Endocrine;Event;follow-up;Future;Gastrointestinal Diseases;Glucose;Goals;Gonadal Steroid Hormones;Health Expenditures;High Risk Woman;hormone therapy;Hospitalization;Hypertension;IL18 gene;Inflammatory;insight;Insulin Resistance;Interleukin-1 beta;Interleukin-6;Intra-abdominal;Investigation;Leptin;Medical;men;menopausal hormone therapy;Menopause;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic syndrome;National Institute of Environmental Health Sciences;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;Obesity;obesity biomarkers;operation;Pathogenesis;Patients;Persons;Postmenopause;pre-clinical;Predisposition;Premenopause;Prevention;Prevention approach;prospective;Prospective cohort;Prospective, cohort study;Puerto Rico;reproductive;Research;resistin;Risk;Role;screening;Serum;sex;Sex Differences;Sister;Testing;Variant;Visceral fat;Visit;Woman;Women's study;Work

PROJECT_TITLE: A prospective cohort study to determine the role of obesity in diverticulitis

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pediatric;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

PHR: PROJECT NARRATIVE The ABCD Study consortium uses multimodal brain imaging, cognitive and clinical assessments, bioassays, mobile monitoring, and careful assessment of substance use, environment, psychopathological symptoms, and social functioning in 11,878 9-10 year-olds to be followed over 10 years, to determine the effects of substance use on adolescent brain and cognitive development. This ABCD Research Project Site will follow and assess participants enrolled in the study. These data will be shared with the scientific community to address a comprehensive range of questions concerning youth development.

PI_NAMEs: LUCIANA, MONICA  (contact);WILSON, SYLIA

PROGRAM_OFFICER_NAME: DEEDS, BETHANY

PROJECT_TERMS: 10 year old;Address;Adolescence;Adolescent;adolescent substance use;Adult;adverse outcome;Affect;Age;Alcohol consumption;Alcohols;Anxiety;assessment application;Athletic Injuries;Behavior;Behavioral;Bioinformatics;Biological;Biological Assay;Biology;Brain;Brain imaging;Caffeine;Calendar;Cannabis;Child;Child Health;Childhood;Clinical assessments;Cognition;Cognitive;cognitive development;cognitive testing;cohort;college;Communities;Country;Data;Data Analyses;Decision Making;design;Development;emerging adult;Emotional;emotional factor;Enrollment;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiology;Ethics;Event;experience;Feeling suicidal;Female;follow-up;Funding;gene interaction;Genetic;Health;Impairment;Individual;Informatics;informatics infrastructure;Interview;Life;Link;Longitudinal Studies;marijuana use;Mental Depression;Mental disorders;Mental Health;Methodology;Methods;Minnesota;mobile application;mobile computing;Monitor;multimodality;neural;Neurocognition;Neurocognitive;neurodevelopment;neuroimaging;Neuropsychological Tests;novel;Occupations;Outcome;Parents;Participant;participant enrollment;participant retention;Pathway interactions;Persons;Physical activity;physical conditioning;Privatization;Process;Protocols documentation;Psychopathology;Qualifying;recruit;Recurrence;Registries;Research;research and development;Research Personnel;Research Project Grants;Resource Informatics;Resources;response;retention rate;Risk;Role;Sampling;Schools;Science;Secure;Severities;Siblings;Site;Sleep;sleep pattern;social;Social Functioning;Social isolation;social media;Specific qualifier value;Sports;Standardization;substance use;Symptoms;Technology;Teenagers;Telephone;temporal measurement;Text;Time;Tobacco;Tobacco use;Training;Traumatic Brain Injury;trend;Triplet Multiple Birth;tv watching;Twin Multiple Birth;United States;vaping;Video Games;young adult;Youth

PROJECT_TITLE: 3/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT U MINNESOTA


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_DEPT: DENTISTRY

PHR: Alphaviruses serve as a model system for studying membrane fusion driven by the class II virus fusion proteins. We aim to elucidate the structural progression of Sindbis virus during membrane attachment, fusion and core release. The knowledge gained from this study will provide a general approach for understanding membrane fusion carried out by enveloped viruses and inform the development of anti-viral strategies.

PI_NAMEs: ZHANG, WEI  (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Address;Affect;Alpha Virus;Anti-viral Therapy;antiviral drug development;Area;Arthritis;Back;Biochemical;Biochemistry;Biological Assay;Biological Models;Biophysics;Capsid;Cells;Cellular Membrane;Centrifugation;Chimeric Proteins;Complex;Cryo-electron tomography;Cryoelectron Microscopy;Cytoplasm;Deposition;Disease;Disease Outbreaks;Drops;Early Endosome;Economic Burden;Encephalitis;Endosomes;Environment;Equus caballus;Event;Flavivirus;Glycoproteins;Goals;Human;Human papillomavirus 16 E1 protein;Image;In Vitro;insight;Knowledge;Length;Licensing;Lipid Bilayers;Liposomes;Mediating;Membrane;Membrane Fusion;Membrane Lipids;Methods;Modeling;Molecular;Molecular Conformation;Molecular Structure;Mutagenesis;mutant;Mutation;novel;Orthobunyavirus;prevent;Process;protein structure;Proteins;prototype;Reaction;receptor;receptor mediated endocytosis;recombinant virus;Recurrence;Research;RNA Viruses;Rubella virus;Sindbis Virus;Site;Structural Models;Structural Protein;Structure;System;Testing;uptake;Vaccines;Viral;Viral Envelope Proteins;Viral Genome;Viral Proteins;Virus;Virus Assembly;Virus Diseases;Work

PROJECT_TITLE: Structural Mechanisms of Alphavirus Membrane Fusion

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]