NIH_SPENDING_CATS: Breast Cancer;Cancer;Neurofibromatosis;Neurosciences;Rare Diseases;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: NARRATIVE Merlin protein is notably lost in advanced breast tumor tissues, in particular, those cases with metastases. There are no specific targeted agents for Merlin-deficient tumors (even those of the nervous system). We will test therapeutically translatable strategies to disable invasive, immunosuppressive, and metastatic attributes of Merlin-deficient mammary tumors using multiple model systems of Merlin-deficient breast cancer.

PI_NAMEs: SHEVDE, LALITA A. (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Acceleration;Actins;Adhesions;Biological Models;Breast Cancer Cell;Breast Cancer Model;cancer cell;Cell Proliferation;Cell Survival;Cell-Cell Adhesion;Cells;Chemoresistance;Clinical Trials;clinically relevant;Cytoskeletal Modeling;Cytoskeletal Proteins;Cytoskeleton;Development;Diagnosis;Ectoderm;Embryo;Embryonic Development;epithelial to mesenchymal transition;Epithelium;Erinaceidae;Exploratory/Developmental Grant;Extracellular Matrix;ezrin;F-Actin;Failure;FDA approved;Foundations;Gene Family;genetic approach;Goals;Growth;Immune Evasion;Immunotherapeutic agent;infiltrating duct carcinoma;inhibitor;innovation;Investigation;Knock-out;Knockout Mice;Link;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mammary Neoplasms;member;Membrane;Membrane Proteins;metabolome;metabolomics;Metastatic breast cancer;migration;Modeling;moesin;Molecular;Morphology;Mus;Mutation;Neoplasm Metastasis;neoplastic cell;Nervous System;Neurofibromin 2;Nodal;Nonmetastatic;novel;novel therapeutic intervention;novel therapeutics;Oral;Organoids;Outcome;Patients;permissiveness;pharmacologic;Phenotype;preclinical study;Process;programs;Proliferating;protein expression;Protein Family;Proteins;radixin protein;receptor;receptor-mediated signaling;Reporting;Role;Scaffolding Protein;Signal Pathway;Signal Transduction;System;targeted agent;Testing;therapeutic evaluation;Tissues;translatable strategy;Translating;Tryptophan Metabolism Pathway;Tryptophanase;tumor;tumor progression;Tumor Suppressor Proteins;Tumor Tissue;Tumor-Derived;tumorigenic;Work

PROJECT_TITLE: Targeting actionable liabilities in Merlin-deficient breast cancer


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Contraception/Reproduction;Infectious Diseases;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: DETROIT

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE To prevent morbidity and mortality in older women and enable medical advances, the defense mechanisms that protect the female genital tract (FGT) from infection and are impaired with aging need to be identified. This proposed research will investigate defense mechanisms that exist in neutrophils. The identification of targetable mechanisms that improve protection against infections in the FGT will open new pathways for the development of prevention strategies for all women as they age.

PI_NAMEs: RODRIGUEZ GARCIA, MARTA  (contact)

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: adaptive immune response;Affect;Age;age related;age related decline;Aging;Anti-viral Response;Antibodies;Atrophic;Biological Assay;Candida;Cell Communication;cell type;Cells;Chlamydia;Communication;Defense Mechanisms;Development;Drug or chemical Tissue Distribution;Early identification;Endocervix;Endometrium;Environment;Epithelial Cells;Epithelium;Exclusion;Exocervix;experience;Female genitalia;female reproductive tract;female reproductive tract infection;first responder;Flow Cytometry;Functional impairment;Gene Expression Profile;genital infection;Genitalia;Genitourinary System Infection;Gonorrhea;high dimensionality;Homeostasis;Human;Hysterectomy;Immune;immune function;Impairment;improved;In Vitro;in vitro Assay;Infection;Infiltration;Inflammation;Injury;Innate Immune Response;Intervention;Knowledge;Learning;Ligands;Literature;Location;Mediating;Medical;Menstruation;Morbidity - disease rate;mortality;mouse model;Mucous Membrane;multiple omics;neutrophil;novel;novel strategies;novel therapeutic intervention;older women;pathogen;pathogenic bacteria;pathogenic fungus;pathogenic virus;Pathology;Pathway interactions;Phenotype;Physiological;Positioning Attribute;Premenopause;prevent;Prevention Research;Prevention strategy;Preventive;Process;receptor;Receptor Signaling;repaired;reproductive;reproductive function;Research;response;RNA;Role;Sampling;senescence;Sexually Transmitted Diseases;Signal Pathway;single cell sequencing;Site;Source;STI prevention;Technology;Testing;Therapeutic;Thinness;Time;Tissues;transcriptome;transcriptomics;translational impact;Urinary tract infection;urogenital tract;Viral;Woman;Women's mortality;Work;wound healing;young woman

PROJECT_TITLE: The impact of aging on neutrophil-mediated protection and inflammation in the female genital mucosa

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 VSR-I (S1)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: NEW HAVEN

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The proposed research is relevant to public health because it provides new strategies for the treatment of solid tumors. This work develops novel tools to improve the application of current chimeric antigen receptor (CAR)- based immunotherapy. In particular, a new type of cell therapy, CAR-mast cells will be developed by innovative bioengineering solutions.

PI_NAMEs: SU, XIAOLEI  (contact)

PROGRAM_OFFICER_NAME: HARRIS, RAYMOND D

PROJECT_TERMS: adaptive immune response;Adoptive Transfer;Allergic inflammation;anti-tumor immune response;Antigens;antitumor effect;Biomedical Engineering;cancer cell;cancer infiltrating T cells;CAR T cell therapy;CCL2 gene;CCL3 gene;CCL4 gene;CD276 gene;CD94 Antigen;Cell Death;Cell secretion;Cell Therapy;cell type;Cells;Cellular biology;chemokine;Chemotherapy and/or radiation;chimeric antigen receptor;Clinical Research;Colon Carcinoma;Correlation Studies;CTLA4 gene;CXCL10 gene;cytokine;cytotoxic;Cytotoxic T-Lymphocytes;cytotoxicity;Data;design;Effector Cell;Engineering;Environment;exhaustion;Foundations;Generations;genetic manipulation;Genome;genome editing;Granzyme;Hematopoietic Neoplasms;Histamine Release;IgE;IL3RA gene;Immune;Immune signaling;Immune system;Immunity;Immunotherapy;improved;In Vitro;in vivo;Infiltration;Innate Immune Response;innovation;Knock-out;life span;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;mast cell;Mediator;Melanoma;Modeling;Natural Killer Cells;novel;novel therapeutic intervention;Outcome;Parasitic infection;Patient-Focused Outcomes;Peptide Hydrolases;Positioning Attribute;preclinical study;programmed cell death protein 1;programs;Public Health;Reagent;receptor;recruit;Refractory;refractory cancer;Relapse;Research;Rest;Risk Assessment;Role;sialogangliosides;side effect;Signal Transduction;Solid Neoplasm;success;synergism;T cell infiltration;T-Lymphocyte;Technology;Tissues;tool;Toxic effect;tumor;Tumor Burden;tumor growth;tumor microenvironment;tumor progression;Tumor Tissue;Vascular Endothelial Growth Factors;Work;Xenograft Model

PROJECT_TITLE: CAR mast cell for solid tumor

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-K (O1)]


ADMINISTERING_IC: EB

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Patient Safety

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative The proposed research is relevant to public health because it focuses on developing a new technology to better interpret and understand cerebrovascular imaging. Once developed there is the potential for significant advances in diagnosis, surgical planning and treatment of cerebrovascular malformations. Thus, the proposed research is relevant to the part of the NIH’s mission that pertains to creating biomedical technologies to improve health.

PI_NAMEs: HAOUCHINE, NAZIM  (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: 3-Dimensional;Adoption;Anatomy;Angiography;Architecture;Arteries;Augmented Reality;Biomedical Technology;Blood flow;Blood Vessels;Brain;Brain hemorrhage;Brain imaging;Cerebral Angiography;cerebral hemodynamics;cerebrovascular;cerebrovascular imaging;cerebrovascular surgery;Cerebrovascular system;Circulation;Classification;Clinical;Clip;Complex;cost effective;Data;Decision Making;deep neural network;Development;Diagnosis;Digital Subtraction Angiography;experience;feeding;Goals;Health;hemodynamics;Hemorrhage;Image;Imaging Techniques;improved;innovation;Intervention;Intuition;Lesion;Machine Learning;machine learning model;malformation;Maps;Methods;Microscope;Microsurgery;Mission;Neuronavigation;new technology;novel;novel strategies;Operating Rooms;Operative Surgical Procedures;Patients;prevent;Procedures;Process;Psyche structure;Public Health;Research;Resolution;Resource-limited setting;Retrospective Studies;Risk;Scanning;Series;Surface;Surgeon;System;Technology;Testing;three-dimensional modeling;Time;tool;United States National Institutes of Health;Veins;virtual;Visual;Visualization;Visualization software

PROJECT_TITLE: New Tools for Enhancing Cerebral Angiography: From Planning to Navigation

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-F (O1)]


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

ORG_STATE: CA

PHR: Project Narrative Tumor-associated macrophages are major components in the tumor microenvironment and play critical roles in tumor immunosurveillance. This study aims to understand the role of protein tyrosine phosphatases in macrophage-mediated cancer cell phagocytosis and evaluate the antitumor efficacy of targeting inhibitory protein tyrosine phosphatases. Identification of such mechanisms will facilitate the development of effective macrophage-based cancer immunotherapy.

PI_NAMEs: FENG, MINGYE  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: anti-cancer;B-Lymphocytes;Biological Process;cancer cell;cancer immunotherapy;Cancer Model;cancer therapy;carcinogenesis;Cell Surface Receptors;Cells;Cellularity;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Colorectal Cancer;Communication;Development;Eating;Engraftment;Excision;Genes;Hematopoietic Neoplasms;Human;Immune;immune cell infiltrate;Immune response;Immunologic Surveillance;immunoregulation;Immunotherapy;In Vitro;in vivo;in vivo Model;infancy;loss of function;Macrophage;Malignant - descriptor;Malignant Neoplasms;Mediating;Modeling;Molecular;mouse model;Natural Killer Cells;neoplastic cell;new therapeutic target;Non-Hodgkin's Lymphoma;novel therapeutic intervention;NR0B2 gene;pathogen;Phagocytes;Phagocytosis;Phagosomes;Play;Pre-Clinical Model;Process;Protein Deficiency;Protein Dephosphorylation;Protein Tyrosine Kinase;Protein Tyrosine Phosphatase;PTPN11 gene;response;Role;screening;Signal Transduction;Solid Neoplasm;src-Family Kinases;T-Lymphocyte;targeted treatment;Therapeutic;tumor;tumor immunology;tumor microenvironment;Tumor-associated macrophages;tumor-immune system interactions;Tyrosine Phosphorylation

PROJECT_TITLE: Non-receptor protein tyrosine phosphatases in macrophage-mediated cancer cell phagocytosis.


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Depression;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Suicide;Suicide Prevention;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: SEATTLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PI_NAMEs: WAGENAAR, BRADLEY  (contact)

PROGRAM_OFFICER_NAME: VEDHAM, VIDYA

PROJECT_TERMS: Address;Adolescent;African;Age;aged;Anxiety;arm;budget impact;Cause of Death;clinically significant;Cluster randomized trial;Cognitive Therapy;Communities;Consolidated Framework for Implementation Research;cost;cost effectiveness;cost estimate;Country;Data;depressive symptoms;Diagnostic;economic evaluation;Effectiveness;effectiveness outcome;effectiveness testing;effectiveness/implementation hybrid;Elements;Evaluation;evidence base;Evidence based practice;experience;Feeling suicidal;Friends;Future;global health;Government;High School Student;HIV/AIDS;ideation;implementation determinants;implementation evaluation;implementation fidelity;implementation outcomes;implementation strategy;implementation/effectiveness;improved;Income;incremental cost;Individual;innovation;Intervention;intervention effect;Knowledge;low and middle-income countries;markov model;Mental disorders;Mental Health;Mental Health Services;Meta-Analysis;microcosting;Motion;Mozambique;novel;Outcome;Personal Satisfaction;Persons;Post-Traumatic Stress Disorders;prevent;Prevention;Prevention program;Prevention strategy;preventive intervention;programs;promote resilience;psychiatric comorbidity;psychiatric symptom;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;reducing suicide;Resources;response;Safety;scale up;Schools;screening;Secondary Schools;service programs;Standardization;suicidal adolescent;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Testing;Time;treatment as usual;Universities;Visit;Washington;Work;young adult;Youth

PROJECT_TITLE: Safety Planning and Cognitive Behavioral Therapy for Adolescent Suicide Prevention in Mozambique: A Hybrid Effectiveness/Implementation Cluster Randomized Trial

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_DEPT: CHEMISTRY

PHR: FAM72A is a mammalian protein that helps antibodies to achieve optimal effectiveness by binding an enzyme, UNG2, and promoting antibody "maturation". FAM72A reduces the activity of the enzyme and also promotes its degradation. In this project we will determine whether the inhibition of activity of UNG2 by FAM72A is sufficient for antibody maturation, or it is necessary for UNG2 to be degraded to achieve optimal immune response.

PI_NAMEs: BHAGWAT, ASHOK S (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: activation-induced cytidine deaminase;Active Sites;Affinity;Antibodies;Antibody Repertoire;Antigens;Antineoplastic Agents;B-Lymphocytes;base;Base Excision Repairs;Binding;Cell Culture Techniques;Cell Line;Cells;Chemicals;Cytosine;Cytosine deaminase;DNA;DNA Damage;DNA Repair;DNA Repair Gene;DNA Repair Pathway;drug development;Effectiveness;Effector Cell;Enzyme Activation;enzyme activity;Enzyme Inhibition;Enzymes;Excision;Family;Fluorescence;Frequencies;Genes;Genetic Recombination;Genome;Germinal Center B-Lymphocyte;Goals;Human Cell Line;IGH@ gene cluster;Immune response;Immune system;Immunoglobulin A;Immunoglobulin Class Switching;Immunoglobulin Genes;Immunoglobulin M;Immunoglobulin Somatic Hypermutation;Immunoglobulin Switch Recombination;In Vitro;Infectious Agent;inhibitor;Knock-out;Knockout Mice;Mammalian Cell;Mammals;Mismatch Repair;Modeling;Molecular;Molecular Immunology;Monitor;multicatalytic endopeptidase complex;Mus;Mutation;Nuclear;Paper;Pathway interactions;Pharmacotherapy;Play;Process;Protac;Protein Isoforms;Proteins;Proxy;Purines;Pyrimidine;repaired;Role;Route;Site;Testing;tool;transition mutation;transversion mutation;Uracil;uracil-DNA glycosylase;Vertebrate Biology;Work

PROJECT_TITLE: The Role of UNG2 Degradation in Antibody Maturation

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE Older adults, particularly frail older adults have greatly increased susceptibility to skin disorders and infections. We will investigate how the skin microbiome modulates skin immunity in healthy and unhealthy aging. This work will lay the foundation for modulating the microbiome-immune axis for therapeutic or prophylactic approaches, and identify risk factors for a range of skin disorders in older adults.

PI_NAMEs: OH, JULIA  (contact)

PROJECT_TERMS: Accounting;adaptive immunity;Address;Adverse event;Affect;Age;age related decline;aged;Aging;aging related;Anterior nares;Anti-Inflammatory Agents;Antibiotics;Biomedical Engineering;Blood;Cell Aging;Cells;Characteristics;Chromosome Mapping;Chronology;cohort;Cutaneous;cytokine;Data;Development;Devices;Disease;dysbiosis;Environment;Environmental Exposure;Ethical Issues;Ethics;experience;Feedback;Flow Cytometry;foot;Foundations;Frail Elderly;frailty;Frequencies;Future;Gender;Genes;Genetic Variation;Goals;gut microbiome;Health;healthy aging;Heterogeneity;Human;Human Genetics;human microbiota;human model;Immune;immune function;Immune response;Immunity;Immunology;Impairment;Inbred Strains Mice;indexing;Individual;Infection;infection risk;Infectious Skin Diseases;Inflammation;Inflammatory;Influentials;innovation;insight;Intercellular Fluid;Investigation;Life Style;Link;Maintenance;Medical;Metagenomics;Microbe;microbial;microbial colonization;microbial products;microbiome;microbiome composition;Mitogen-Activated Protein Kinase Inhibitor;Modeling;mouse model;Mus;Natural Immunity;Needles;older adult;oral microbiome;p38 Mitogen Activated Protein Kinase;Painless;pathogen;pathogenic microbe;Pathway interactions;Penetrance;Phenotype;Physiological;Physiology;Population;Predisposition;Productivity;prophylactic;Publishing;reconstitution;Recording of previous events;recruit;Research;response;Risk;Risk Factors;Sampling;senescence;senolytics;Shotguns;Site;Skin;Skin Aging;skin barrier;Skin Cancer;skin disorder;skin microbiome;Skin Tissue;Staphylococcus aureus;Structure;Subcutaneous Injections;Surveys;Swab;Systemic infection;Testing;The Jackson Laboratory;Therapeutic;Thick;ultraviolet irradiation;Viral;Work;young adult

PROJECT_TITLE: Skin immunity as a function of frailty, aging, and skin microbiome composition


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Infectious Diseases

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE Currently used therapeutics for intraocular bacterial infections include antibiotics (which kill organisms) and anti-inflammatory drugs (whose value for these infections is controversial). This proposal will test the utility of blocking key innate immune pathways to eliminate damaging inflammation during intraocular bacterial infections. The proposed experiments are novel, high-impact, translationally relevant, and will identify whether targeting innate immune pathways with antibiotics is a feasible strategy for treating the eye during intraocular infections.

PI_NAMEs: CALLEGAN, MICHELLE C (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Adrenal Cortex Hormones;Anti-Inflammatory Agents;Antibiotics;Area;Bacillus;Bacteria;bacterial endophthalmitis;Bacterial Eye Infections;Bacterial Infections;Bilateral;blind;Blindness;Blood-Retinal Barrier;Cataract Extraction;Cells;cellular targeting;Clinical;clinically relevant;Combined Antibiotics;Communicable Diseases;Dangerousness;Data;Development;Dexamethasone;Diabetic mouse;Dose;Drug Design;Effectiveness;effectiveness evaluation;efficacy evaluation;efficacy testing;Endophthalmitis;Equation;ESKAPE pathogens;Experimental Designs;experimental study;Eye;Eye Infections;falls;Gatifloxacin;Genetic;Goals;Growth;Health;Hour;Human;Immune system;improved;Individual;ineffective therapies;Infection;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;innate immune pathways;intravitreal injection;Klebsiella;Klebsiella pneumoniae;Mediating;migration;Modeling;Multi-Drug Resistance;Mus;Neutrophil Infiltration;novel;Operative Surgical Procedures;Organism;Outcome;oxidized phosphatidyl choline;pathogen;Pathogenesis;Pathway interactions;Patients;Permeability;Pharmaceutical Preparations;Phospholipids;Physicians;Postoperative Period;prednisolone;preservation;prevent;Process;Production;programs;prophylactic;recruit;Regimen;Reporting;Research;response;Retina;Speed;Staphylococcus aureus;Strategic Planning;Streptozocin;success;Systemic infection;Testing;Therapeutic;Therapeutic Uses;therapy outcome;Tissues;Toll-Like Receptor Pathway;Toxin;treatment arm;Vancomycin;Virulent;Vision;Work

PROJECT_TITLE: Targeting Innate Inflammation Pathways to Treat Ocular Infections

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Pediatric Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Rehabilitation;Social Determinants of Health

ORG_CITY: STANFORD

ORG_DEPT: PEDIATRICS

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The long-term health risks of childhood cancer therapy have been known for decades, yet adherence to lifelong survivorship care is poor and inequitable, and this leads to health disparities. Communication among young adult childhood cancer survivors, parents/caregivers, and clinicians is essential for survivors to learn to manage their care, but it is complex and even more challenging for families who prefer a language other than English. This project will address these gaps by partnering with a community organization to develop, pilot test, and refine the first culturally and linguistically tailored family-centered communication intervention for Latinx young adult childhood cancer survivors and their parents/caregivers, working toward the goal of improving survivorship care in this population at risk for health disparities.

PI_NAMEs: SMITH, STEPHANIE M. (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adult;Age;arm;Behavior Therapy;Behavioral Model;bilingualism;California;Cancer Survivor;Cancer Survivorship;cancer survivorship care;cancer therapy;career;career development;Caregivers;Caring;Childhood;childhood cancer survivor;Chronic;Clinical Research;Communication;Communication Barriers;Communities;community academic partnership;community based participatory research;community engaged research;community engagement;Community Health Aides;community involvement;community organizations;community partners;Complex;Data;design;Development Plans;Diagnosis;Disparity;disparity reduction;Education;efficacy testing;Ethnic Origin;experience;Face;Family;Feedback;Focus Groups;Future;Goals;Guidelines;Health;health disparity;health outcome disparity;Hispanic;human centered design;improved;Income;Inequity;Institution;Insurance;Intervention;intervention refinement;Interview;iterative design;Language;Latino;Latinx;Lead;Learning;Life;Linguistics;low socioeconomic status;Malignant Childhood Neoplasm;Malignant Neoplasms;Medical;Medical History;member;Mentorship;Modeling;nonEnglish language;Nonprofit Organizations;novel;Oncology;Outcome;Parents;patient oriented;Physicians;pilot test;Population;Populations at Risk;preference;primary outcome;Process;Race;Randomized;Randomized, Controlled Trials;Recommendation;Recording of previous events;Reduce health disparities;Research;research study;Risk;Role;Science;Scientist;Screening for cancer;Services;skills;social health determinants;social stigma;Socioeconomic Status;Spanish/English;Structure;Survivors;survivorship;Testing;therapy design;therapy development;Training;Translating;Treatment Efficacy;trend;underserved community;Underserved Population;United States National Institutes of Health;Visit;Work;young adult

PROJECT_TITLE: Leveraging a community-academic partnership to pilot a family-centered communication intervention for Latinx young adult childhood cancer survivors

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE When host white blood cells, called macrophages, are infected or injured, a series of signals may cause the macrophage to commit a form of cellular “suicide” called necroptosis. This cell suicide can promote a response of the human immune system called inflammation. We have discovered a new means by which necroptosis suicide may cause inflammation in the body by causing the dying cell to produce molecules called lipids which drive inflammation.

PI_NAMEs: PERKINS, DARREN  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Anabolism;Apoptosis;Cell Death;cell killing;Cell Line;Cell Membrane Permeability;cell suicide;Cell surface;Cells;Cessation of life;Coupled;cytokine;Cytokine Receptors;Cytokine Signaling;Disease;disease model;Eicosanoid Production;Eicosanoids;Elements;Endosomes;experimental study;Family;Genetic Transcription;Genetically Engineered Mouse;healing;Homeostasis;Host Defense;Human;Hyperactivity;Immune;Immune system;Immunologic Receptors;Immunologics;immunoregulation;In Vitro;in vivo;Infection;Infection Control;Inflammation;Inflammatory;Inflammatory Response;injured;Innate Immune Response;insight;ischemic injury;Kinetics;Leukocytes;Ligand Binding;Ligands;Link;lipid mediator;lipid metabolism;Lipids;Macrophage;Mediating;microbial;Modeling;Molecular;Necrosis;operation;Organ;pathogen;Pathogenesis;Pathologic;Pathology;Pathway interactions;Pattern;Pattern Recognition;Phospholipase;Phosphotransferases;Polyunsaturated Fatty Acids;Process;Production;programs;protein protein interaction;response;response to injury;RIPK1 gene;RIPK3 gene;Role;Rupture;Series;Shapes;Signal Transduction;Speed;Suicide;systemic inflammatory response;therapeutic target;Tissues;TLR4 gene;TNF gene

PROJECT_TITLE: Innate immune receptor driven programmed necrosis is coupled to hyper-synthesis of inflammatory lipid mediators in host defense

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Human Fetal Tissue;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE  The proposed research seeks to gain a deeper understanding of the genetic programs that regulate the development of specialized areas within the human cerebral cortex. Abnormalities in this process can result in neurodevelopmental disorders including autism spectrum disorder, epilepsy, intellectual disability, and neuropsychiatric diseases. By exploring the mechanisms behind the development of distinct cortical areas, this research has the potential to provide valuable insights into the causes of these disorders and inform the development of new treatments.

PI_NAMEs: QIAN, XUYU  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Address;Advisory Committees;Affect;Age;Area;autism spectrum disorder;Award;Benchmarking;Bioinformatics;Boston;Brain;career;career development;cell type;Cells;Cerebral cortex;Data;Defect;Development;Developmental Process;Diagnosis;differential expression;Dimensions;Disease;Disease susceptibility;DNA Sequence Alteration;dosage;Embryo;Environment;Epilepsy;Etiology;Experimental Models;fetal;First Pregnancy Trimester;Fluorescent in Situ Hybridization;follow-up;Foundations;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic analysis;Genetic Diseases;Genetic Markers;Goals;Growth;Health;Human;human pluripotent stem cell;human stem cell-derived;human stem cells;human tissue;improved;In Situ Hybridization;in vitro Model;in vivo;insight;Institution;Intellectual functioning disability;Knowledge;Laboratories;medical schools;Mentors;Mentorship;Methodology;Methods;Modeling;morphogens;nerve stem cell;neural patterning;Neurodevelopmental Disorder;neurogenetics;Neurons;neuropsychiatric disorder;Organoids;Outcome;Outcomes Research;Pediatric Hospitals;pharmacologic;Phase;Play;Pregnancy;Process;programs;Protocols documentation;Research;Research Personnel;Resolution;Resources;Role;Sampling;Signal Pathway;Signal Transduction;Specific qualifier value;stem cell model;Structure;supportive environment;Synapses;Testing;Thalamic structure;Time;tissue stem cells;Training;transcriptome;transcriptome sequencing;transcriptomics;Work

PROJECT_TITLE: Development of Distinct Areas in the Human Cerebral Cortex

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: EAST LANSING

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative: Nut Carcinoma (NC) is an aggressive cancer with no effective treatment. We have built the first genetically engineered mouse model of NC and will genetically humanize the model to allow preclinical studies of human NUTM1-targeted therapies. The humanized model can potentially transform the landscape of NC therapy development and benefit NC patients.

PI_NAMEs: GU, BIN  (contact)

PROGRAM_OFFICER_NAME: SHARMAN, ANU

PROJECT_TERMS: Adaptor Signaling Protein;Affinity;Amino Acids;Antisense Oligonucleotide Therapy;Basal Cell;Basal cell carcinoma;Breeding;cancer initiation;Carcinoma;Cell Line;Cells;Characteristics;Child;Childhood Acute Lymphocytic Leukemia;Childhood Leukemia;childhood sarcoma;Chimera organism;Chromosomal translocation;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Complementary DNA;CRISPR/Cas technology;Data;Dependence;design;Development;Diagnosis;DNA;DNA cassette;Ectopic Expression;effective therapy;Ensure;Epithelial Cells;Epithelium;Event;Fostering;Functional dependence;fusion gene;Gene Components;Gene Modified;gene replacement;Gene Structure;gene therapy;Genes;Genetic;Genetically Engineered Mouse;Genomic DNA;Genomics;homologous recombination;Human;Human Characteristics;humanized mouse;in vivo;Karyotype;knock-down;Knowledge;Malignant Neoplasms;Messenger RNA;Modeling;Molecular;mouse model;Mus;Mutation;nanobodies;novel;novel therapeutics;Nut carcinoma;Oncogenic;Patients;Pattern;Pre-Clinical Model;preclinical development;preclinical study;Prognosis;Proliferating;Protac;protein aminoacid sequence;Proteins;Proteolysis;Publishing;Quality Control;Reagent;Reporter;Rest;RNA Splicing;side effect;Site;small molecule inhibitor;Squamous cell carcinoma;Squamous Differentiation;stem cells;Study models;targeted treatment;Testis;Therapeutic;Therapeutic Index;therapeutic target;therapy development;Time;Tissues;Transcript;transcriptome;tumor;tumor growth

PROJECT_TITLE: Developing humanized Nut Carcinoma mouse model for developing NUTM1 targeted therapies.

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-P (O2)]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dental, Oral, and Craniofacial Disease;Eating Disorders;Mental Health;Neurosciences;Nutrition;Obesity

ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: ROCKEFELLER UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATION It seems obvious that when our body is low in energy we will eat, however, it is not known how the sensation of the bodily energy state transforms into the movements of chewing and biting. This interplay of signals reflecting the state of the body and control of muscles and movement that make up behavior is a tightly regulated process, and any decoupling will result in either obesity or eating disorders. Thus, this proposal aims to determine the computations that a simple brain circuit performs to control biting and chewing of food with respect to changes in energy state of the body.

PI_NAMEs: KOSSE, CHRISTIN  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, KARI ANNE

PROJECT_TERMS: Address;Advisory Committees;Afferent Neurons;Area;Behavior;Behavior assessment;Behavior Control;behavioral response;Bite;bodily sensation;body sense;Brain;brain based;Brain Stem;brain tissue;Brain-Derived Neurotrophic Factor;Calcium;career;career development;Cell Nucleus;cell type;Cells;cellular imaging;Code;computer studies;Consumption;Coupling;Data;design;Eating;Eating Disorders;Electrophysiology (science);Esthesia;Etiology;Exclusion;Fasting;feeding;Feeding behaviors;fighting;follow-up;Food;food consumption;Fright;Functional Imaging;Future;Genetic Transcription;Goals;High Fat Diet;Hunger;Hypothalamic structure;Image;In Situ Hybridization;insight;Instinct;Interoception;Jaw;jaw movement;Knock-out;Lead;Mammals;Manuscripts;Maps;Mastication;Mentors;Molecular;molecular marker;Monitor;Motor;motor control;Motor Neurons;Movement;Mus;Muscle;neural;neuromechanism;Neurons;Neuropeptides;neuroregulation;Neurosciences;Nuclear RNA;Obesity;obesity treatment;optogenetics;Partner in relationship;Pattern;Phase;Process;programs;pup;Rabies virus;Research;RNA;Role;Sensory;Signal Transduction;skills;Slice;Smell Perception;social;Social Behavior;Social Interaction;stem;Structure;Structure of nucleus infundibularis hypothalami;Synapses;targeted imaging;Testing;Thinness;Training;training opportunity;transcriptome sequencing;transcriptomics;Universities;Vertebral column;Vision

PROJECT_TITLE: Encoding of Bodily State and Motor Action in a Minimal Circuit for Food Consumption

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-P (02)]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE U.S. universities are unsuccessful at enrolling, retaining, and graduating underrepresented (UR) biomedical science (BS) students, creating a dearth of UR workforce. A diverse BS workforce will address health disparities via a more comprehensive, higher quality research agenda. The aims in this research training plan will increase the number of UR BS students, faculty, and researchers, thereby, serving Arkansas and the U.S.

PI_NAMEs: ALLEN, ANTINO RECIO;THOMAS, BILLY R (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Development;Students

PROJECT_TITLE: Initiative for Maximizing Student Development(IMSD)

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Cancer;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Orphan Drug;Prevention;Radiation Oncology;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Radiation optic neuropathy (RON) is a devastating complication of radiation-based cancer treatments that can lead to blindness, and there are currently no effective treatments to prevent this. Development of a relevant animal model is essential to better understand this disease. The proposed experiments will both develop an animal model of RON and take the first steps toward novel treatment approaches to reduce blindness and maintain quality of life for radiation-treated cancer patients.

PI_NAMEs: DALVIN, LAUREN A;RODDY, GAVIN W (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Acceleration;Address;Adrenal Cortex Hormones;Adult;Anatomy;Animal Model;Appearance;Automobile Driving;Axonal Transport;Blindness;Brain Neoplasms;Cancer Patient;cancer therapy;Characteristics;Choroid Melanoma;Clinical;Clinical Data;clinical practice;cohort;Complication;Connective Tissue;Cranial Irradiation;Data;Development;Disease;disease phenotype;effective therapy;experimental study;Exposure to;Eye;Glaucoma;Goals;Histopathology;Human;human disease;Human Pathology;interest;Intervention;Lead;Left;Magnetic Resonance Imaging;Modeling;Multimodal Imaging;Neuroprotective Agents;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Optic Disk;Optic Nerve;optic nerve disorder;Optic Nerve Injuries;Outcome;Pallor;Pathogenesis;Pathology;Patients;Phenotype;Physiologic Intraocular Pressure;Predisposition;preservation;pressure;prevent;Prevention;Primates;Quality of life;Radiation;Radiation exposure;Radiation induced damage;Radiation Injuries;radiation mitigation;radiation response;radiation risk;Radiation therapy;Regulation;Retrospective Studies;Risk;Risk Factors;Risk Reduction;Rodent;Role;Secondary to;Severities;side effect;Study models;Testing;Thinness;Time;tissue stress;Traction;Treatment Side Effects;tumor;Tupaiidae;Uveal Melanoma;Validation;Vascular Endothelial Growth Factors;Vision;Visual;Weight-Bearing state;Work

PROJECT_TITLE: Characterization and treatment of a novel model of radiation optic neuropathy using the tree shrew

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-X (O1)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Genetics;Hematology;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PHR: PROJECT NARRATIVE Clonal hematopoiesis of indeterminate potential (CHIP), which refers to the presence of detectable recurrent genetic mutations in blood cells, is a common condition of aging. CHIP is significantly associated with many diseases with a strong inflammatory component and is also typified by increased and/or dysregulated inflammatory signals. This proposal seeks to understand how the NLRP3 inflammasome, a central regulator of inflammation, promotes Tet2-mutated clonal hematopoiesis and how it may be targeted therapeutically.

PI_NAMEs: WONG, WAIHAY J (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: Advisory Committees;Aging;Anatomy;ATAC-seq;Biological;Biology;Blood;Blood Cells;bone cell;Bone Marrow;Bone Marrow Transplantation;Cardiovascular Diseases;career;CD34 gene;cell behavior;Cell Compartmentation;Cell Separation;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;chemokine;Chromatin;chronic liver disease;Chronic Obstructive Pulmonary Disease;clinical training;Clonal Expansion;Computer Analysis;Coronary heart disease;CXCL1 gene;cytokine;Dana-Farber Cancer Institute;Development;Disease;disease model;Disease Outcome;DNA Sequence Alteration;DNMT3a;Educational process of instructing;Environment;Epigenetic Process;experience;experimental study;fitness;Gene Mutation;Genes;Genetic Transcription;Goals;Gout;Hematologic Neoplasms;Hematological Disease;Hematology;Hematopathology;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Hospitals;Human;Human Genetics;human model;IL6 gene;Immune;In Vitro;in vivo;Indirect Immunofluorescence;Individual;Inflammasome;Inflammation;Inflammatory;Innate Immune Response;insight;International;K-Series Research Career Programs;Kupffer Cells;Liver;Macrophage;Manuscripts;Marrow;Measures;Mediating;Medical Oncology;medical schools;Medicine;meetings;Mentors;Methods;Modeling;mouse model;Mus;mutant;Mutate;Mutation;Myelogenous;Myeloid Cells;Myeloproliferative disease;Natural Immunity;Nature;neoplastic;next generation sequencing;Osteoporosis;Pathogenesis;Pathology;Pathway interactions;Patients;pharmacologic;Physicians;Population;Pre-Clinical Model;Preleukemia;Preneoplastic Conditions;Production;professor;programs;Proto-Oncogene Protein c-kit;Publications;Recurrence;Research;Research Personnel;Role;Scientist;Signal Transduction;single cell sequencing;Somatic Mutation;Specimen;Steatohepatitis;stem cell population;stem cells;targeted agent;targeted treatment;Technology;Testing;Therapeutic;Tissues;Training;Training Programs;transcriptome sequencing;Transplantation;United States National Institutes of Health;Woman;Work;Xenograft procedure

PROJECT_TITLE: Defining the role of NLRP3 inflammasome in clonal hematopoiesis

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (OA)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);Neurosciences;Nutrition;Substance Misuse

ORG_CITY: Princeton

ORG_DEPT: NEUROSCIENCES

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Humans and other animals learn the value of foods based on their postingestive effects and thereby develop preferences for the taste of foods that are nutrient-rich and aversions towards those that produce illness. This taste learning process is critical for survival but can become maladaptive in eating disorders and obesity and in clinical settings such as during chemotherapy. This proposal will uncover the brainwide neural representations of flavor and test how those representations are reconfigured by the arrival of postingestive feedback from the gut to ultimately shape our preferences and aversions for specific tastes.

PI_NAMEs: ZIMMERMAN, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Amygdaloid structure;Anatomy;Animals;Behavior Control;Brain;Brain region;chemotherapy;Chronic;Clinical;Code;computerized tools;Consumption;Data;density;detection of nutrient;Development;drinking;Eating;Eating Disorders;Electrophysiology (science);Exclusion;experience;experimental study;Feedback;follow-up;Food;Food Preferences;FOS gene;Functional disorder;Genetic;Goals;Hour;Human;Hypothalamic structure;Image;Immediate-Early Genes;Implant;innovation;insight;Label;Lateral;Learning;Link;Machine Learning;Malaise;Measures;Memory;Mission;Modeling;Motivation;Mus;neural;neuromechanism;Neurons;Neurosciences Research;novel;Nutrient;Obesity;Odors;optogenetics;Pathway interactions;Pattern;Phase;Population;Positive Valence;Postdoctoral Fellow;preference;Presynaptic Terminals;prevent;Process;recruit;Shapes;Signal Transduction;Smell Perception;Stimulus;Stomach;Surveys;Synapses;Synaptic plasticity;Taste aversion;Taste Perception;Taste preferences;Technical Expertise;Techniques;Testing;theories;tool;Toxin;Training;Transgenic Organisms;Ventral Striatum;virtual;Visceral;With laterality

PROJECT_TITLE: Cross-region neural mechanisms that support conditioned taste aversion


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Progressive Supranuclear Palsy (PSP) is a severe brain disease of aging that is usually fatal within five to seven years after diagnosis. PSP has no cure, but because it shares a key biological feature with Alzheimer’s disease (AD), accumulation of tau protein in the brain, new treatments developed for AD and other neurodegenerative diseases might be equally or more effective to treat PSP. Building on recent advances in drug development and clinical trial methods, this project will test the ability of three new therapies to slow clinical disease progression and brain volume loss in PSP and will create a large amount of new data to share with other researchers to help develop new PSP diagnostic tests and therapies in the future.

PI_NAMEs: BOXER, ADAM L. (contact);LITVAN, IRENE ;ROJAS-MARTINEZ, JULIO CESAR;WILLS, ANNE-MARIE

PROGRAM_OFFICER_NAME: RYAN, LAURIE M

PROJECT_TERMS: Accounting;Activities of Daily Living;aging related disease;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;arm;axon guidance;Binding;Biological;Biological Markers;biomarker discovery;Blinded;Brain;Brain Diseases;brain volume;Caring;cerebral atrophy;Cessation of life;Chondroitin Sulfate Proteoglycan;Clinical;clinical trial protocol;Clinical Trials;Cognitive;cognitive function;Collaborations;Conduct Clinical Trials;Data;Decision Making;Deposition;design;Diagnosis;diagnostic biomarker;Diagnostic tests;diagnostic tool;Disease Progression;drug development;Drug Industry;effective therapy;efficacy trial;England;Enrollment;Etiology;experience;Funding;Future;Generations;Genes;Genetic;genetic risk factor;Goals;Impaired cognition;impression;inclusion criteria;Individual;Infrastructure;Inherited;International;Investigational Therapies;Lipids;Liquid substance;lysosomal proteins;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;mental state;Methods;Microtubules;Midbrain structure;multimodality;Natural History;Neurodegenerative Disorders;Neuroglia;Neurons;neuroprotection;North America;novel therapeutics;Nucleic Acid Regulatory Sequences;Oncology;open label;Outcome;Parkinson Disease;Participant;Patients;Pharmaceutical Preparations;pharmacodynamic biomarker;Phase;Placebo Control;placebo group;Placebos;Plasma;pre-clinical;preservation;programs;Progressive Supranuclear Palsy;Proteins;Quality of life;Randomized;recruit;Research;Research Infrastructure;Research Personnel;Resources;response;Safety;safety testing;secondary endpoint;Severity of illness;Site;Symptoms;Syndrome;targeted treatment;tau aggregation;tau Proteins;Tauopathies;Testing;Therapeutic;Time;treatment effect;trial planning;United States National Institutes of Health

PROJECT_TITLE: The Progressive Supranuclear Palsy Clinical Trial Platform (PTP)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-D (02)]


NIH_SPENDING_CATS: Clinical Research;Microbiome

PHR: Narrative: ABO(H) blood group antigens were the first human polymorphisms described and corresponding anti-ABO(H) antibodies continue to be the most common immunological barrier to transfusion and transplantation. However, despite their discovery over a century ago, the factors responsible for anti-ABO(H) antibody development remain relatively unknown. Using a series translational studies coupled with a new preclinical model of anti-blood group antibody formation, I will leverage my existing training in transfusion immunology with training in glycobiology to define key factors that influence the overall levels and specificity of anti-ABO(H) antibodies.

PI_NAMEs: JAJOSKY, RYAN P (contact)

PROGRAM_OFFICER_NAME: HAILU, BENYAM

PROJECT_TERMS: ABO blood group system;Antibodies;Antibody Formation;Antibody Response;Antibody titer measurement;Antigens;B-Lymphocytes;Binding;Blood;blood group;Blood Group Antigens;Blood typing procedure;carbohydrate structure;CD4 Positive T Lymphocytes;Cell Count;Clinical;Coupled;Cross Reactions;Data;Development;Enzymes;Etiology;Event;experience;Exposure to;Foundations;gag Gene Products;Genetic Polymorphism;Glycobiology;Goals;Hemolysis;Human;immune function;Immunoglobulin-Secreting Cells;Immunologics;Immunology;Individual;Klebsiella pneumoniae;Knock-out;Lead;Life;Link;lonely individuals;Microbe;microbial;microbiota;Mus;Pathway interactions;Patients;Polysaccharides;Pre-Clinical Model;Process;programs;Reaction;Research;Role;Series;Shapes;skills;Sorting;Specificity;Testing;Training;training opportunity;Transfusion;transfusion medicine;translational immunology;translational study;Transplantation;Welding

PROJECT_TITLE: Etiology of naturally-occurring anti-ABO antibodies


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Precision Medicine

ORG_CITY: Auburn

ORG_DEPT: PSYCHOLOGY

ORG_NAME: AUBURN UNIVERSITY AT AUBURN

PHR: PROJECT NARRATIVE Social avoidance behavior (SAB) plays a key role in the development and maintenance of internalizing disorders such as Major Depressive Disorder and Social Anxiety Disorder, but is largely resistant to current treatments. The proposed research seeks to address this issue by using precision neuromodulation to regulate motivational and neural processes that contribute to SAB across internalizing disorders.

PI_NAMEs: EVANS, TRAVIS CLARK (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Address;Affective;Anger;Anterior;avoidance behavior;Behavioral;Brain Mapping;Chronic;cingulate cortex;Clinical Trials;Conflict (Psychology);Crossover Design;Data;Development;Diagnostic;Disease;Evidence based treatment;Facial Expression;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Happiness;innovation;Intervention;Investigational Therapies;Maintenance;Major Depressive Disorder;Measures;Mentorship;Motivation;motivational processes;network dysfunction;Network-based;neural;neural circuit;neural network;neuroimaging;neuromechanism;neuroregulation;Neurosciences;Nodal;novel;Patients;Play;precision medicine;precision neuromodulation;Prefrontal Cortex;premature;Process;programs;Protocols documentation;remediation;Research;Resistance;response;Rest;Rewards;Role;Severities;social;Social Anxiety Disorder;Social Behavior;social deficits;stem;Symptoms;System;Training;Transcranial magnetic stimulation;translational applications;Withdrawal

PROJECT_TITLE: Personalized Neuromodulation Targeting Dysregulated Motivational Responses Underlying Social Avoidance Behavior

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Clinical Research;Data Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Fetal growth restriction (FGR) is a leading cause of perinatal morbidity and mortality, yet current diagnostic approaches do not allow for individualized risk assessment. We propose to develop individualized models for fetal growth potential and risk of perinatal morbidity using maternal genetic data and a novel explainable artificial intelligence technique. This will generate new insights and lay the groundwork for a shift to personalized fetal growth assessment, assisting clinicians and improving care for women and infants by reducing uncertainty.

PI_NAMEs: BLUE, NATHAN RICHARD (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: Address;Adult;adverse outcome;Area;Artificial Intelligence;artificial intelligence method;Assessment tool;authority;Award;biomedical informatics;Birth;Birth Weight;Black Box;cardiovascular disorder risk;career;career development;Caring;Cerebral Palsy;Cessation of life;Clinical;Clinical Data;clinical decision support;Clinical Research;cohort;Complex;Computational Biology;computerized tools;congenital heart abnormality;Data;Data Science;Dependence;design;Diagnosis;diagnostic strategy;Discipline of obstetrics;explainable artificial intelligence;Family;fetal;fetal diagnosis;Fetal Growth;Fetal Growth Retardation;Fetal Weight;Fetus;fetus at risk;Foundations;Functional disorder;Genetic;genetic information;Genetic Risk;genetic variant;genome sequencing;genomic data;Genomics;Goals;Growth;Height;Human Genetics;improved;Infant;informatics tool;innovation;insight;Interdisciplinary Study;International;Leadership;Link;Maternal-fetal medicine;Medical;Mentors;Metabolic syndrome;Methodology;Methods;Modeling;Monitor;Morbidity - disease rate;Mothers;multidisciplinary;Multiomic Data;Myocardial Infarction;National Institute of Child Health and Human Development;neonatal morbidity;novel;Nulliparity;obstetrical complication;Outcome;Outcome Study;Output;Pediatric cardiology;Perinatal;perinatal complications;perinatal morbidity;Perinatal mortality demographics;personalized predictions;Physicians;Placenta;Population;population based;postnatal;predictive modeling;Pregnancy;Pregnancy Outcome;Pregnant Women;prenatal;prevent;Prospective cohort;Prospective Studies;psychosocial;Psychosocial Factor;Publishing;Pythons;Race;Research;Research Personnel;Risk;Risk Assessment;Risk Estimate;Risk Factors;risk stratification;Scientist;Seizures;Silver;Single Nucleotide Polymorphism;skill acquisition;skills;SNP array;social factors;social health determinants;Software Tools;stillbirth;Stroke;Sudden infant death syndrome;synergism;Techniques;Technology;Testing;time use;tool;transcriptome;Translational Research;trustworthiness;ultrasound;Uncertainty;Visualization;Weight;whole genome;Woman

PROJECT_TITLE: Individualization of Fetal Growth Assessment using Maternal Genetics and Explainable AI

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Obstetrics and Maternal-Fetal Biology Study Section[CHHD-B]


ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative In this proposal we will investigate the in vivo efficacy of an anti-GITR antibody utilizing a novel, engineered Fc domain that induces spontaneous hexamerization upon cell surface binding without inducing immune effector functions. We will study how hexamerization augments antibody mediated signaling in vivo and we seek to understand how the combination of checkpoint blockade with an agonistic antibody remodels the tumor microenvironment and restores anti-tumor immunity.

PI_NAMEs: MARASCO, WAYNE A. (contact)

PROGRAM_OFFICER_NAME: HARRIS, RAYMOND D

PROJECT_TERMS: Address;advanced analytics;anti-PD-1;anti-PD-L1;anti-PD1 antibodies;anti-PD1 therapy;Antibodies;antibody engineering;Antibody Therapy;Antitumor Response;Binding;Biological Assay;Bispecific Antibodies;cancer immunotherapy;Cell surface;Cells;Cellular Immunity;Clear cell renal cell carcinoma;Clinical;Combined Modality Therapy;comparative efficacy;Complement;Complement 1q;Complement-Dependent Cytotoxicity;CTLA4 gene;cytotoxic;Deposition;Development;Engineering;Evaluation;exhaust;exhaustion;Fc domain;Gases;Human;humanized mouse;IgG1;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;Immune system;Immunohistochemistry;Immunotherapy;improved;In Vitro;in vitro testing;in vivo;in vivo evaluation;insight;interest;Ligands;Luciferases;Malignant Neoplasms;Mediating;member;Modeling;Monoclonal Antibodies;monomer;mouse model;Mus;mutant;Mutation;Natural Killer Cells;Nature;neoplastic cell;novel;Orthoptics;Pathway interactions;Patients;PD-1/PD-L1;Principal Investigator;programmed cell death ligand 1;programmed cell death protein 1;programs;receptor;Receptor Signaling;Regulatory T-Lymphocyte;Renal Cell Carcinoma;response;restoration;Role;Series;Signal Transduction;single-cell RNA sequencing;Structure;Surface;T-Cell Activation;Techniques;Technology;Therapeutic;Therapeutic antibodies;Therapeutic Uses;TNFRSF5 gene;Treatment Efficacy;tumor;Tumor Immunity;tumor microenvironment;Tumor Necrosis Factor Receptor;Variant;Writing

PROJECT_TITLE: In vivo testing of an agonistic anti-GITR mAb that induces cell surface clustering to augment signal transduction and a 2nd Gen bispecific anti-GITR/PD1 Ab derivative for improved anti-tumor activity

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-1 (O2)]


NIH_SPENDING_CATS: Biotechnology;Breastfeeding, Lactation and Breast Milk;Clinical Research;Genetics;Human Genome;Microbiome;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Breastfeeding provides health benefits for infants and mothers, but the specific effects of the numerous components of human milk are largely unknown. This project represents a comprehensive genetic and genomic analysis of human milk composition, which will improve our understanding of the genes and biological pathways underlying milk composition and enabling future studies of the health consequences of variation in milk components. This study also leverages multi-omic data integration to assess the effects of milk composition on the infant gut microbiome and infant immune development.

PI_NAMEs: JOHNSON, KELSEY ELIZABETH (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Adult;Amino Acids;Biological;biological systems;Biology;Breast Feeding;career;Cells;Cellular biology;Clinical;Clinical Research;Clinical Virology;cohort;Community Health;Computing Methodologies;Core Facility;cytokine;Cytomegalovirus;Data;data integration;Development;disorder risk;Epidemiology;Exposure to;feeding;Foundations;Future;Gene Expression;Genes;Genetic;genetic epidemiology;genetic variant;Genomic approach;Genomics;gut health;gut microbiome;Health;Health Benefit;Health Status;Hormones;Human;Human Milk;Immune;Immune response;Immune system;Immunity;Immunologics;Immunology;immunoregulation;improved;Infant;Infant Development;infant gut microbiome;Infant Health;infant outcome;Inflammation;inflammatory marker;Institution;Investigation;Knowledge;Kynurenine;Lactation;Learning;Life;Lipids;longitudinal dataset;Machine Learning;mammary;Mammary gland;Maternal Health;Measures;Mentors;metabolome;metabolomics;microbial;microbiome;Milk;Minnesota;Mothers;multimodal data;Multiomic Data;multiple omics;novel;nutrition;Pathway interactions;pediatric department;Phase;Phenotype;poor health outcome;postnatal;postnatal human;Predisposition;Premature Infant;Recommendation;Research;Research Personnel;Research Training;Resources;response;Role;sample collection;Sampling;Serum;Serum Markers;Shapes;skill acquisition;small molecule;sugar;System;Techniques;Technology;Testing;Training;transcriptome;Translational Research;Twin Cities;Universities;Variant;virology;Virus;Work

PROJECT_TITLE: Genetic and genomic influences on human milk composition and impacts on infant health

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Childhood Obesity;Clinical Research;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Networking and Information Technology R&D (NITRD);Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: FORT COLLINS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative Type 2 diabetes (T2D) and cardiovascular diseases (CVD) are serious public health problems that disproportionately affect persons of color and families facing economic hardship. Attention to the role of mental and behavioral health in the prevention of T2D and CVD, prioritization of community-engaged research with diverse stakeholders, and application of dissemination and implementation science are critical to developing significant and innovative preventative interventions to reduce population-level T2D and CVD health disparities. The training and research aims of this K24 proposal leverage Dr. Shomaker's current clinical trials in patient- oriented research on T2D and CVD risk prevention in adolescents and families to train the next generation of clinician investigators in mental/behavioral health and T2D/CVD prevention.

PI_NAMEs: SHOMAKER, LAUREN BERGER (contact)

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;Advisory Committees;Affect;American Psychological Association;Area;Attention;Award;Behavioral;behavioral health;Behavioral trial;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;career;Cause of Death;child depression;Clinical;Clinical Investigator;Clinical Trials;Collaborations;Color;Colorado;Committee Members;Communities;community engaged research;Computers;Development;disorder risk;dissemination science;Doctor of Philosophy;doctoral student;Early Intervention;Economics;Education;Educational process of instructing;Effectiveness;equity, diversity, and inclusion;ethnic health disparity;experience;Faculty;Family;Foundations;Funding;Goals;Grant;Health;health disparity;implementation science;Incidence;Information Technology;innovation;Institution;Insulin Resistance;Intervention;K-Series Research Career Programs;Knowledge;Lead;Leadership;lens;Licensing;Life Cycle Stages;Life Style;Medical;Medical center;Mental Health;Mentors;Mentorship;Metabolic syndrome;Mid-Career Clinical Scientist Award (K24);Midcareer Investigator Award in Patient-Oriented Research;Modeling;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Paper;patient oriented research;Pediatric Hospitals;people of color;Population;pre-doctoral;prevent;Prevention;preventive intervention;programs;progression risk;Psyche structure;psychologic;Psychologist;puberty transition;Public Health;racial health disparity;Research;Research Personnel;Resources;Risk Factors;Role;rural area;Scholarship;Science;Scientist;Secure;Services;Site;skills;social;social adversity;Solid;standard of care;Stress;Students;technology intervention;Time;tool;Training;Translational Research;United States National Institutes of Health;Universities;urban setting;virtual;Work

PROJECT_TITLE: Mentored Research in Adolescent Mental, Behavioral, and Cardiometabolic Health

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (OA)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BURLINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: PROJECT NARRATIVE Brain capillaries are the site of nutrient and waste exchange throughout the entire brain. Ubiquitous coverage of brain capillaries allows them to sense brain activity and modulate blood flow. Here I test the novel hypothesis that brain capillary pericytes and endothelial cells are equipped with KATP channels and are electrically coupled allowing them sense hypoxia and regulate blood flow.

PI_NAMEs: KLUG, NICHOLAS RYAN (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Ablation;Address;Adenosine;ADORA2A gene;Altitude;Alzheimer's Disease;Animal Model;Animals;Arteries;arteriole;Astrocytes;Blood capillaries;Blood flow;Blood Vessels;Brain;brain health;Brain Hypoxia;brain pericytes;Brain region;Capillary Endothelial Cell;Career Mobility;Cell Separation;Cells;Central Nervous System;cerebral capillary;Cerebrovascular Circulation;Cerebrovascular system;Collaborations;Communication;Coupled;Coupling;Cyclic AMP-Dependent Protein Kinases;Dedications;Diameter;Drops;electrical property;Electrophysiology (science);Endothelial Cells;Ensure;Environment;Event;extracellular;Functional Magnetic Resonance Imaging;Funding;Genetic;Hyperemia;Hypertension;Hypotension;Hypoxia;Image;imaging approach;In Situ;in vivo;insight;Internet;Investigation;Ion Channel;Ischemia;Kir2.1 channel;Knock-out;Knowledge;Laboratories;Laser-Doppler Flowmetry;Ligands;Measures;Mediating;Membrane Potentials;Mentored Research Scientist Development Award;Mentors;Metabolic;Microelectrodes;Microvascular Dysfunction;Modeling;Myography;neural;Neuroglia;Neurons;neurovascular coupling;novel;Nutrient;optical imaging;Oxygen;patch clamp;Pathologic;Pericytes;pharmacologic;Phase;Physiological;Physiology;Positioning Attribute;Potassium Channel;Preparation;pressure;Process;Property;Proteins;Purinergic P1 Receptors;receptor;Recording of previous events;Regulation;Research;Research Personnel;response;Role;Sensory;Signal Transduction;Site;Stimulus;Stroke;Structure;Techniques;Testing;Time;Tissues;tool;Training;Tube;tumor growth;two photon microscopy;United States National Institutes of Health;Universities;Vascular blood supply;Vascularization;Washington;wasting

PROJECT_TITLE: Regulation of blood flow in the brain by capillary KATP channels

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-O (O3)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Neurosciences

PHR: Project Narrative Hippocampus is an important brain region for learning and memory, and is frequently impacted in common neurological diseases such as Alzheimer's disease and epilepsy, causing memory impairments. In this project, I propose to use state-of-the-art large-scale electron microscopy imaging techniques followed by reconstruction to map the connectivity between cells in the hippocampus. The results can provide important insights into the neural mechanism of learning and memory in the hippocampus.

PI_NAMEs: ZHENG, ZHIHAO  (contact)

PROJECT_TERMS: Alzheimer's Disease;Anatomy;Brain region;Calcium;cell type;Cells;cellular imaging;Code;Cognitive;connectome data;Data;Data Set;deep learning;Doctor of Philosophy;Ego;Electron Microscopy;Electrophysiology (science);Environment;Epilepsy;Episodic memory;excitatory neuron;Exposure to;Frequencies;Functional Imaging;Goals;Hippocampus;Image;imaging study;Imaging Techniques;Influentials;insight;Interneurons;Learning;Link;Location;Maps;Memory;Memory impairment;Methods;microscopic imaging;millimeter;Modeling;Molecular;nanoscale;Nervous System Disorder;neural;neural circuit;neural patterning;neuroimaging;neuromechanism;Neurons;neurophysiology;Neuropil;Neurosciences;place fields;post-doctoral training;presynaptic;programs;Property;Pyramidal Cells;reconstruction;Recording of previous events;Recurrence;Research;Resolution;skills;spatial memory;Specificity;Structure;success;Synapses;Synaptic plasticity;System;Techniques;Testing;Theoretical model;Time;Tissue Stains;Training;Transmission Electron Microscopy;two-photon;way finding;X-Ray Computed Tomography

PROJECT_TITLE: Circuit structure of cognitive maps in the hippocampus


ORG_CITY: Newark

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: PROJECT NARRATIVE The project proposed here seeks to address a major obstacle for therapeutic gene editing in oncology, namely that of tumor specificity. This will be achieved through the combination of phage display and CRISPR/Cas gene editing, both of which are powerful and well-established technologies with major therapeutic potential for oncology patients.

PI_NAMEs: ARAP, WADIH ;PASQUALINI, RENATA  (contact)

PROJECT_TERMS: Address;Adipose tissue;Angiogenesis Inhibitors;Bacteriophages;Binding;Bone Marrow;Brain;cancer cell;Cancer Model;Capsid;Capsid Proteins;Cell Surface Receptors;cell type;Cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR therapeutics;Data;Dependovirus;design;Development;Diagnostic;Disease;Elements;Engineering;Ensure;Evaluation;Gene Delivery;gene editing technology;Gene Expression;Gene Proteins;gene-editing approach;Genes;genetic element;Goals;Guide RNA;Homing;Human body;Hybrids;In Vitro;in vitro testing;in vivo;in vivo evaluation;Injections;insight;Integrins;Intestines;Kaposi Sarcoma;Kidney;Lead;lead candidate;Ligands;Light;Liver;Malignant - descriptor;Malignant Neoplasms;Mammalian Cell;Mediating;Messenger RNA;Methods;Minor;Modeling;Mus;nanoparticle;Nature;neoplastic cell;novel;novel therapeutic intervention;nuclease;Oncogenic;Oncology;overexpression;Pancreas;particle;Patients;Peptides;Phage Display;phage vector;precursor cell;Prostate;protein expression;Proteins;receptor;receptor binding;RNA Sequences;Sampling;Satellite Viruses;Series;Skeletal Muscle;Specificity;System;targeted treatment;Technology;Testing;Therapeutic;therapeutic development;therapeutic genome editing;therapy design;Tissues;tool;Transgenes;Treatment Efficacy;tumor;Tumor Specific Peptide;tumor specificity;Tumor Tissue;Tumor-Associated Vasculature;tumor-specific gene delivery;vector;Viral Vector

PROJECT_TITLE: Ligand-directed therapeutic CRISPR/Cas gene editing in tumor cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-V (O1)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Gene Therapy;Genetics;Immunotherapy

ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE Failure of transferred immune cells to travel to and infiltrate tumors is a leading cause of failure for adoptive immune cell therapies. Here, we will engineer immune cells to express “homing” molecules to direct these cells to colorectal cancer and overcome this limitation. We will use laboratory models to see if this approach is safe and effective in animal models with the long-term goal of creating a safe and effective therapy for colorectal cancer patients.

PI_NAMEs: KIM, SANGWON VINCENT;SNOOK, ADAM  (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Adoptive Transfer;Anatomy;Animal Model;Antigen Targeting;Biological Models;Cancer Model;cancer therapy;cancer type;CAR T cell therapy;Cell Therapy;Cells;cellular development;Cellular immunotherapy;Cessation of life;chemokine;chemokine receptor;chimeric antigen receptor T cells;Clinic;Clinical;Clinical Management;Clinical Trials;Colon;colon cancer cell line;colon cancer patients;Colorectal;Colorectal Cancer;colorectal cancer treatment;comparative efficacy;Data;Disease;Dissection;effective therapy;engineered T cells;Engineering;Failure;FDA approved;Future;Goals;GPR15 gene;Hematologic Neoplasms;Home;Homing;Human;human model;Immune;Immunity;immunoengineering;Immunologic Factors;Immunologics;imprint;improved;in silico;In Vitro;in vitro testing;in vivo;Infiltration;Laboratories;Ligands;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;manufacture;Metabolic;metastatic colorectal;Modeling;Modification;mouse model;Mucin 1 protein;Mus;Normal tissue morphology;novel therapeutics;overexpression;Patient-Focused Outcomes;Patients;peripheral blood;Phase;Pre-Clinical Model;programs;receptor;recruit;Refractory;Regulatory T-Lymphocyte;Risk;Safety;Schedule;Signal Transduction;Solid;Solid Neoplasm;Survival Rate;T cell infiltration;T-Lymphocyte;Testing;Therapeutic;Tissues;Toxic effect;trafficking;translational approach;translational study;Travel;tumor;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes

PROJECT_TITLE: Ligand-Induced Recruitment of CAR-T Cells to Colorectal Cancers

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-F (O1)]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_CITY: CHAPEL HILL

ORG_DEPT: DENTISTRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE The onset of periodontitis involves an influx of immune cells and a cascade of inflammatory biomolecules in response to a dysbiotic microbiota. Interleukin-37, an anti-inflammatory cytokine, is dysregulated in severe forms of periodontitis; however, its role in the disease’s pathogenesis remains poorly defined. The proposed research will begin to unravel the complex processes that interleukin-37 employs during periodontal inflammation with emphasis on regulatory mechanisms required for its bioactivity in the innate immune response by the periodontium.

PI_NAMEs: LIETZAN, ADAM  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: acquired immunity;Adult;Affect;Animal Model;Anti-Inflammatory Agents;Award;Basic Science;Binding;Binding Proteins;Biological Models;bone;career development;cell type;Cells;Chemicals;Chronic;Clinical;clinical care;Clinical Management;Complex;Coupled;cytokine;Data;Development;Discipline;Disease;Disease Progression;dysbiosis;Environment;Epithelial Cells;Epithelium;Equilibrium;Event;Exhibits;experience;experimental study;Exposure to;extracellular;Extracellular Matrix;Family;Family member;Gene Expression;genome wide association study;Gingiva;Gingival Crevicular Fluid;Glycosaminoglycans;Goals;Health;Heparitin Sulfate;Immune;Immune response;Immunity;Immunohistochemistry;Immunologics;Immunology;improved;In Vitro;in vivo;in vivo Model;Individual;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;inflammatory milieu;Inflammatory Response;Innate Immune Response;interdisciplinary approach;Interleukin-1;Interleukin-1 beta;Interleukins;Intervention;Knowledge;Leadership;Link;Macrophage;Mediating;member;Mentors;Mentorship;Messenger RNA;Microbe;microbial;microbiota;Modeling;Mucous Membrane;multidisciplinary;Natural Immunity;Necrotizing Enterocolitis;Oral;oral cavity epithelium;oral immunity;pathobiont;pathogen;Pathogenesis;Pathway interactions;Periodontal Attachment Loss;Periodontitis;Periodontium;Phenotype;Process;professor;programs;Property;receptor;Research;Research Activity;research and development;Research Assistant;Research Support;Research Training;response;restraint;Role;School Dentistry;Scientist;Severities;Signal Transduction;Signaling Molecule;skills;Specimen;Stimulus;Structure;Surface;Techniques;Testing;Therapeutic;Tissues;Training;Training Activity;United States;Variant;Writing

PROJECT_TITLE: DECIPHERING MECHANISMS OF IL-37 MEDIATED CONTROL OF PERIODONTAL INFLAMMATION

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative The orexin system is an attractive potential therapeutic target that demonstrated its involvement in drug addiction. The development of a novel radioligand for PET imaging targeting orexin 1 receptor would be useful in order to quantify the orexin 1 receptors in vivo.

PI_NAMEs: KOVACIC, ISABELLE  (contact)

PROGRAM_OFFICER_NAME: LE, HOANG VAN

PROJECT_TERMS: Acceleration;addiction;adverse outcome;Affinity;Alcohols;American Psychiatric Association;Amides;analog;Animal Model;antagonist;Area;Behavior;Beta-N-Acetylglucosaminidase;Binding;Biology;Bolus Infusion;Brain;Brain region;Cell Nucleus;Chronic;Cocaine;conditioned place preference;Cues;Data;design;Detection;Development;Disease;Drug Addiction;Drug Design;drug of abuse;Emotions;Evaluation;experimental study;Future;G-Protein-Coupled Receptors;Hippocampus;Human;Hydrogen Bonding;hypocretin;Hypothalamic structure;Image;imaging probe;In Vitro;in vivo;Individual;interest;Investigation;Kinetics;Knockout Mice;Label;Lateral;Lead;Ligands;Link;lipophilicity;Methods;Morphine;Neurons;Neuropeptides;novel;opioid misuse;orexin 1 receptor;orexin A;orexin B;Papio;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Positron-Emission Tomography;prepro-orexin;Radiolabeled;radioligand;radiotracer;receptor;Regulation;Relapse;Reporting;Research;Research Activity;reward processing;Rewards;Rodent;Role;SB-334867;Signal Pathway;Site;Sulfonamides;Symptoms;System;targeted imaging;Testing;Thalamic structure;therapeutic target;Time;Tracer;trait;Urea;Wakefulness;Work

PROJECT_TITLE: Development of novel radioligand for PET imaging targeting the orexin 1 receptor

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Cardiovascular;Clinical Research;Disability Research;Heart Disease;Physical Activity

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Heart failure with preserved ejection fraction (HFpEF) is a growing clinical problem costing the US healthcare system >$30 billion annually by 2030, and characterized by severe exercise intolerance (EI), exertional fatigue, disability, and increased mortality. The proposed research will develop a new MRI-based tool to simultaneously measure skeletal muscle energy metabolism and blood flow, two potentially important contributors to EI in HFpEF, and utilize modern wearable health technology devices to assess EI during activities during daily living. These new tools will also be utilized to examine whether skeletal muscle energy metabolism, blood flow, and activities of daily living improve following administration of a metabolic modulator medicine (sodium-glucose cotransporter-2 inhibitors) in HFpEF patients, the results from which will provide new understanding and possible treatments to improve muscle metabolism and decrease disability in HFpEF patients.

PI_NAMEs: SAMUEL, THOMAS JAKE (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: actigraphy;Activities of Daily Living;Age;Attenuated;Award;Blood flow;Blood Preservation;Cardiac Output;Cardiovascular system;career;career development;Cell Respiration;Chemicals;Clinical;Clinical Research;Clinical Trials Design;comparison control;Complex;Consumption;cost;Data;Devices;disability;Disabling;EFRAC;Elements;Energy Metabolism;Exercise;exercise capacity;exercise intolerance;Exercise Test;Exertion;experience;Fatigue;fitbit;Future;Glucose;Healthcare Systems;Heart failure;heart preservation;Impairment;improved;improved outcome;in vivo;indexing;Inherited;inhibitor;inhibitor therapy;inorganic phosphate;insight;laboratory experiment;Life;Link;Longitudinal Studies;Magnetic Resonance;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measures;Medicine;Mentorship;Metabolic;Metabolism;Methodology;Methods;Mitochondria;mitochondrial oxidative dysfunction;moderate-to-vigorous physical activity;Modernization;Monitor;mortality;multidisciplinary;Muscle;muscle metabolism;Muscle Mitochondria;Myopathy;novel;Outcome;Oxygen;Oxygen Consumption;Pathway interactions;Patients;peripheral blood;Persons;Phosphorus;Pilot Projects;preservation;Quality of life;randomized trial;Randomized, Controlled Trials;Reporting;Reproducibility;Research;Resolution;Resource Development;response;sedentary;sedentary activity;sedentary lifestyle;Skeletal Muscle;skeletal muscle metabolism;Sodium;symporter;Symptoms;Syndrome;Testing;Time;tool;Training;Transferable Skills;Walking;wearable device;wearable health device

PROJECT_TITLE: Muscle metabolism, metabolic modulators and disabling exercise intolerance in the daily life of patients with heart failure and preserved ejection fraction

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI (OA)]


ORG_DEPT: BIOCHEMISTRY

PHR: Narrative Our long-term goal is to produce highly skilled UNC alumni to diversify the biomedical workforce leadership. We have established a comprehensive, personalized, start-to-finish program led by a team of dedicated PhD-trained Directors to develop, recruit, and empower PhD students from groups that are under-represented in the sciences, particularly at key transition points. We implement programs and activities that foster scientific identity, self-efficacy, leadership skills, and a supportive community to equip students to thrive in future scientific careers.

PI_NAMEs: FREEMAN, ASHALLA MAGEE;KASH, THOMAS L.;TAMAYO, RITA  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Development;Students

PROJECT_TITLE: UNC Initiative for Maximizing Student Development


ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

ORG_STATE: MI

PHR: PROJECT NARRATIVE A subgroup of bladder cancer patients who are treated with immune checkpoint inhibitors (ICI) develop and succumb to hyperproliferative immune-related adverse events (HP-irAEs), for reasons that are unknown. I discovered a genetic and metabolic signature for HP-irAE that seems to pre-condition the tumor environment for HP-irAE before ICI treatment. By understanding how the genetic and metabolic pathway is differentially activated in tumor and immune cells within the tumor microenvironment, we will be able to better stratify bladder cancer patients before ICI treatment, and identify new opportunities for future drug discovery and precision medicine efforts to minimize HP-irAE in ICI-treated patients.

PI_NAMEs: JANG, HYO SIK  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Acceleration;Adverse event;Advisory Committees;anti-PD-L1 therapy;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Basic Science;Binding;Bladder;Bladder Neoplasm;Cancer Biology;cancer cell;Cancer Patient;cancer therapy;cancer type;Carcinogens;career;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cessation of life;checkpoint therapy;Clinical;Clinical Trials;CYP1A1 gene;Data;Dependence;Detection;Deterioration;Disease;Dreams;drug discovery;Drug Screening;Environment;Epigenetic Process;Equilibrium;Evolution;exhaust;experimental study;Fatty Acids;Future;Genetic;Genetic Screening;Genetic Transcription;Goals;Grant;Heterogeneity;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune Evasion;Immune System Diseases;immune-related adverse events;Immunology;Immunosuppression;In Vitro;in vivo;in vivo Model;insight;Label;Ligands;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methods;Modeling;Molecular;mouse model;multidimensional data;multidisciplinary;multimodality;Mus;nano-string;Oncogenic;overexpression;Pathway interactions;patient population;Patients;Pattern;Peripheral;Phase;Positioning Attribute;precision medicine;prevent;Process;prognostic indicator;programmed cell death ligand 1;programs;Progressive Disease;Proliferating;protein expression;Proteomics;Receptor Activation;recruit;Research;Resistance;response;Role;Sampling;Shapes;Signal Pathway;Signal Transduction;single cell sequencing;single cell technology;skills;Solid;Source;Subgroup;Testing;Therapeutic;Training;Transcript;Transcriptional Activation;Translational Research;Treatment Efficacy;treatment response;tumor;tumor growth;tumor metabolism;tumor microenvironment;tumor progression;tumorigenesis;Work;Xenobiotic Metabolism;Xenograft Model;Xenograft procedure

PROJECT_TITLE: The role of AHR in modulatingimmunotherapy response and adverse events in bladder cancer

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Social Determinants of Health;Women's Health Research

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Social animals depend on vocal communication for survival in many contexts, and the brain must extract information from acoustic features of calls and communicate with circuits for appropriate behavioral responses. Depending on the call meaning, this processing must occur over time scales needed for guiding various behaviors. The research proposed here tests the overall hypothesis that top-down circuits in the auditory system facilitate vocalization-guided behaviors across contexts, using multiple methods for monitoring and manipulating activity in neurons and ensembles to dissect the circuits involved in driving behavior.

PI_NAMEs: LEMESSURIER, AMY  (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TITLE: Neural circuitry and population dynamics for perception of social vocalizations in the auditory pathway

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-P (02)]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: PROJECT NARRATIVE Pathological synaptic connectivity is implicated in a number of neurological disorders, including devastating neurodegenerative diseases such as Alzheimer's disease. Tools for characterizing the function and synaptic structure of neural circuits in both the healthy and diseased brain are therefore critical for understanding the etiology of such neurological disorders. This proposal thus focuses on developing computational methods for holographic optogenetics to enable large-scale yet precise control and monosynaptic mapping of neural circuits.

PI_NAMEs: TRIPLETT, MARCUS  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, KARI ANNE

PROJECT_TERMS: Algorithms;Alzheimer's Disease;Architecture;authority;Brain;brain behavior;Brain Diseases;Calcium;Cells;Collection;Complex;computational neuroscience;Computing Methodologies;cost;Custom;Data;Data Analyses;design;Electron Microscopy;Electrophysiology (science);Etiology;experimental study;Faculty;Goals;Heterogeneity;hologram;holographic stimulation;Holography;Image;In Vitro;in vivo;Individual;insight;Interneurons;Lasers;Light;Location;Machine Learning;machine learning algorithm;Maps;Mentorship;method development;Methods;Mind;Modeling;Monitor;multimodality;Nervous System;Nervous System Disorder;neural;neural circuit;Neurodegenerative Disorders;neuronal cell body;Neurons;Neurophysiology - biologic function;neuroregulation;Neurosciences;Neurosciences Research;novel;Opsin;Optical Methods;Optics;optogenetics;patch clamp;Pathologic;Pathway interactions;Pattern;Phase;Photons;Physiological;Population;Positioning Attribute;Postdoctoral Fellow;postsynaptic;presynaptic;Recurrence;response;Scientist;Somatosensory Cortex;spatiotemporal;Specific qualifier value;Speed;Stimulus;Structure;success;Synapses;Synaptic Potentials;Target Populations;targeted imaging;Techniques;Technology;Time;tool;Training;two photon microscopy;two-photon;Universities;voltage;Work

PROJECT_TITLE: Computational Methods for Precise Holographic Control and Mapping of Neural Circuits


NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lung;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Project Narrative The proposed study is a secondary data analysis of administrative hospital discharge data to examine environmental risk factors for pediatric acute respiratory disease. The project will utilize participant data that has already been collected as part of the New York Department of Health Statewide Planning and Research Cooperative System (SPARCS) dataset. The overall objective of the proposed work is to examine the independent and combined effect of ambient air pollution and neighborhood-level characteristics on pediatric acute respiratory disease hospitalizations.

PI_NAMEs: FEILER, MARINA OKTAPODAS;KULICK, ERIN RYAN (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: 5 year old;Acute;Acute Disease;Acute respiratory infection;Address;Age;age difference;Air;Air Pollution;Allergic rhinitis;ambient air pollution;Antibody Repertoire;Area;asthma exacerbation;Behavioral;Black Populations;Black race;Body System;built environment;Characteristics;Child;Childhood;Cities;climate change;Clinical;comorbidity;Complex;Crime;Cross-Over Studies;current pandemic;Data;Data Analyses;Data Set;Databases;Demographic Factors;density;deprivation;Development;Disease;Endocrine;Endocrine system;Enrollment;Environmental Risk Factor;ethnic disparity;Ethnic Origin;Ethnic Population;Exposure to;future pandemic;Green space;Growth and Development function;Health;Health Planning;high risk;Hormones;Hospitalization;hospitalization rates;Hospitals;Immune;Immune system;Immunologic Markers;improved;Inequality;Infection;interest;Knowledge;land use;Latinx population;Life;Life Cycle Stages;life span;Low income;Low Income Population;Lower Respiratory Tract Infection;male;Measurement;Measures;Minority;minority children;Minority Groups;Modeling;Neighborhoods;New York;Otitis Media;Outcome;Participant;pathogen;Pattern;Philadelphia;Population;Pregnancy;Public Health;Race;racial population;Research;Research Design;respiratory;Respiratory Disease;respiratory health;respiratory morbidity;Respiratory System;Respiratory Tract Infections;Risk;Risk Factors;Role;Sampling;sex;sociodemographic factors;Socioeconomic Factors;Socioeconomic Status;statistics;Stimulus;stressor;System;Systems Development;Time;Toxic Environmental Substances;Underrepresented Populations;United States;United States Environmental Protection Agency;Upper Respiratory Infections;Urban Population;Vaccination;walkability;Work

PROJECT_TITLE: Examining the Association between Residential Ambient Air Pollution and Pediatric Hospitalization due to Acute Respiratory Disease Across New York State

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


ORG_CITY: HOUSTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative: The Baylor College of Medicine Initiative for Maximizing Student Development (BCM- IMSD) will mentor underrepresented graduate students (UR) in science and medicine to be successful in research-intensive biomedical Ph.D. programs and pursue research and research-related careers. The training includes support for mentoring, original research in a laboratory, science writing and oral presentation skills, analysis of the scientific and medical literature, critical thinking and evaluation, responsible research conduct, and scientific rigor and reproducibility principles. The BCM-IMSD student scholars will develop knowledge and experience in foundational science and clinical and translational research, ask critical questions supplemented with mentorship and training in leadership, teamwork, and communication skills that foster confidence and independence, and serve as role models for UR students, colleagues, and the broader diverse communities about biomedical research and healthcare.

PI_NAMEs: PANGAS, STEPHANIE A.;PEREIRA, FRED A (contact)

PROJECT_TERMS: college;Development;Medicine;Students

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Lung;Pulmonary Hypertension

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Pulmonary Hypertension (PH) is a lethal disease with no effective treatment due to a limited understanding of the underlying mechanisms that cause extreme vascular proliferation and remodeling in the pulmonary circulation. Our data indicate that mitochondrial dysfunction leads to increased expression of Aminopeptidase N in vascular cells - pericytes, causing them to proliferate and contribute to severe vascular remodeling in PH. This discovery has crucial clinical significance, potentially leading to new treatments targeting excessive vascular proliferation.

PI_NAMEs: JAMES, JOEL  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: 3-Dimensional;Address;Advisory Committees;alanine aminopeptidase;angiogenesis;Arizona;Arteries;Attenuated;Behavior;Biology;Blood capillaries;Blood Vessels;Cardiovascular Diseases;career;career development;Cell Communication;Cell Proliferation;cell type;Cells;Characteristics;clinically significant;Coculture Techniques;confocal imaging;Data;Data Analyses;Development;Development Plans;Disease;Dissociation;effective therapy;Endothelial Cells;Ensure;Environment;Event;Exhibits;Extramural Activities;Faculty;Failure;Favorable Clinical Outcome;Funding;Grant;Homeostasis;Human;Impairment;In Vitro;in vitro Assay;in vivo;Incidence;Individual;Institution;interest;Invaded;knock-down;Knowledge;Laboratories;Life;Maintenance;Mediating;Medicine;meetings;member;Mentors;Metabolic;migration;mitochondrial dysfunction;Mitochondrial Proteins;Modeling;Morphology;Mutation;Nature;novel;overexpression;p21-activated kinase 1;Patch-Clamp Techniques;Pathologic;Patients;Peptides;Pericytes;pharmacologic;Phase;Phenotype;Play;Positioning Attribute;Proliferating;Property;Protein Overexpression;Proteins;Publications;Pulmonary arterial remodeling;Pulmonary artery structure;Pulmonary Circulation;Pulmonary Hypertension;Rattus;Records;Research;research and development;Research Methodology;response;Rest;Right Ventricular Hypertrophy;Role;RUNX1 gene;Secure;Signal Transduction;Signaling Protein;single-cell RNA sequencing;skills;Smooth Muscle;Smooth Muscle Myocytes;Source;Stimulus;success;Survival Rate;Technical Expertise;Techniques;tenure track;Testing;Thioctic Acid;Three-Dimensional Imaging;Training;transcription factor;transcriptomics;translational impact;United States National Institutes of Health;Universities;Vascular Proliferation;Vascular remodeling;Western Blotting;Work

PROJECT_TITLE: Aminopeptidase N Driven Signaling in the Development of Pulmonary Hypertension


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Prostate Cancer;Urologic Diseases

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative  The incidence of prostate cancer, the most common malignancy and the second leading cause of cancer- related mortality in men in the United States, increases substantially over 50 years of age and in parallel, the prevalence of hip replacement surgery also increases in that age group. Multiparametric magnetic resonance imaging (mpMRI) plays an important role in the diagnosis and disease management of prostate cancer, however, mpMRI is challenging in men with hip implants due to severe image distortions and signal loss. In this study, we will establish a robust mpMRI using our novel acquisition and reconstruction strategy that can be widely implemented across all MR scanners for better management of prostate cancer patients with hip implants and subsequently improve their quality of life and overall survival.

PI_NAMEs: MADHURANTHAKAM, ANANTH J (contact)

PROGRAM_OFFICER_NAME: KIM, BOKLYE

PROJECT_TERMS: 3-Dimensional;Address;age group;Age Years;American;Biopsy;Cancer Etiology;Cancer Patient;cancer risk;Classification;Clinical;clinical imaging;clinical translation;Clinical Trials;clinically significant;Cold Therapy;density;Detection;Development;Diagnosis;Diffusion;Diffusion Magnetic Resonance Imaging;Disease Management;Echo-Planar Imaging;experience;Focused Ultrasound Therapy;follow-up;Goals;Guidelines;healthy volunteer;high risk men;High-Risk Cancer;Hip region structure;hip replacement arthroplasty;Histopathology;human subject;Image;Implant;improved;in vivo;Incidence;Individual;Information Systems;Lesion;magnetic field;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;men;Metals;Methods;Monitor;Morphologic artifacts;mortality;next generation;Noise;novel;Operative Surgical Procedures;Outcome;Patient Care;Patient Monitoring;patient population;Patients;Pelvis;Peripheral;Play;Prevalence;prospective;Prostate;prostate biopsy;prostate cancer risk;prostate lesions;Prostate-Specific Antigen;Prostatectomy;Quality of life;radioligand;Recommendation;reconstruction;Reference Standards;Reporting;research clinical testing;Role;Signal Transduction;targeted treatment;Techniques;treatment planning;ultrasound ablation;United States;Urethra;urologic;Visualization

PROJECT_TITLE: Novel 3D DWI for Detection and Characterization of Prostate Cancer in Men with Pelvic Metal Implants

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-X (O1)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Sleep Research

ORG_CITY: CHICAGO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative The ability generalize learned knowledge to different contexts is crucial for effective navigation in the world, and impairments in generalization are hallmarks of many disorders, including autism, schizophrenia, and post-traumatic stress disorder. This research aims to expand our understanding of how the hippocampus, a brain structure critical for contextual learning and memory, can encode task information in various contexts. To investigate how the hippocampus can generalize learning, we will record and perturb hippocampal and downstream structures' activity during learning tasks performed in diverse environments.

PI_NAMEs: WIRTSHAFTER, HANNAH S (contact)

PROGRAM_OFFICER_NAME: CHURCHILL, JAMES D

PROJECT_TERMS: Address;Affect;Animals;Area;autism spectrum disorder;Behavior;Behavior Control;behavior influence;Behavioral;behavioral response;Binding;Brain;Calcium;Cells;Characteristics;Code;Conditioned Reflex;Cues;Data;data modeling;Dimensions;Disease;Disparate;Distal;Electrophysiology (science);Environment;Faculty;Fire - disasters;Goals;Hippocampus;Image;Imaging Device;Impairment;Implant;in vivo calcium imaging;Knowledge;Laboratory Research;Lateral;Learning;Location;Maps;Mathematics;Memory;memory consolidation;Methodology;Methods;Modality;Movement;Mus;neural;neural correlate;Neurons;Neurosciences;non rapid eye movement;optogenetics;Outcome;Pattern;Performance;Play;Population;Positioning Attribute;Post-Traumatic Stress Disorders;Principal Investigator;Psychological Transfer;Rattus;REM Sleep;Research;Rest;Role;Schizophrenia;Signal Transduction;Sleep;Sleep Stages;Speed;Stimulus;Structure;System;Techniques;tenure track;Testing;theories;Time;Training;transfer learning;Work

PROJECT_TITLE: Identifying and manipulating behavioral and neural correlates of contextual learning