NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

PHR: NARRARTIVE We are using a basic biology approach grounded in host-pathogen interactions to discover new compounds that disrupt the infection process. This represents the earliest possible stage of antibiotic discovery and relies upon bacterial cell physiology, in vitro, and in vivo infection models to identify workable new research directions.

PI_NAMEs: DETWEILER, CORRELLA S (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Affect;Animals;Anti-Bacterial Agents;Antibiotics;antimicrobial;Antimicrobial Resistance;antimicrobial resistant infection;Bacteria;Bacterial Infections;bactericide;Biological;biological adaptation to stress;Biology;Ceftriaxone;Cell Culture System;Cell Culture Techniques;cell envelope;cell injury;Cell Membrane Permeability;Cell Physiology;cell type;Cells;cellular targeting;Chemicals;Clinical;Combating Antibiotic Resistant Bacteria;Cytolysis;Data;Disease;efflux pump;fighting;fluidity;Generations;Goals;Gram-Negative Bacteria;Gram-Negative Bacterial Infections;Gram-Positive Bacteria;Growth;human pathogen;In Vitro;in vivo;Infection;inhibitor;innate immune mechanisms;Ion Transport;Laboratories;Lipid Bilayers;Macrophage;Maintenance;Mammalian Cell;Membrane;Microbial Biofilms;Modeling;multi-drug resistant pathogen;Mus;mutant;Natural Immunity;novel strategies;pathogen;pathogenic bacteria;Pathway interactions;periplasm;Permeability;Predisposition;prevent;Process;Production;Protons;Protoplasts;Research;Salmonella;Salmonella typhimurium;Signal Transduction;small molecule;Stress Response Signaling;Testing;Tissues;tool;Toxic effect;transcriptome;voltage

PROJECT_TITLE: Infection-Dependent Vulnerabilities of Gram-negative Bacterial Pathogens


ADMINISTERING_IC: DA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Pediatric;Primary Health Care;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE/RELEVANCE Despite rising rates of daily cannabis use in young adults and elevated risk for adverse cognitive, psychiatric, and social outcomes, very few young adults with cannabis use disorder (CUD) receive treatment, with disparities by sex and race/ethnicity. This project will use rigorous quantitative and qualitative methods to test the feasibility and preliminary efficacy of MOMENT-V, a novel, fully-remote telehealth and mHealth intervention in primary care, as a means of facilitating treatment for the vulnerable and underserved population of young adults with CUD.

PI_NAMEs: SHRIER, LYDIA A. (contact)

PROGRAM_OFFICER_NAME: SEYMOUR, KAREN ELIZABETH

PROJECT_TERMS: addiction;Address;Adherence;adverse outcome;Affect;aged;Area;barrier to care;behavior test;Behavior Therapy;Benchmarking;Brain;brief intervention;brief motivational intervention;Cannabis;Cognition;Cognitive;cognitive function;Counseling;design;Development;disparity reduction;Education;education resources;Educational Materials;Effectiveness;effectiveness testing;effectiveness trial;Electronics;Eligibility Determination;Emotions;Enrollment;ethnic minority population;Ethnic Origin;experience;Eye;Face;Feasibility Studies;feasibility testing;feasibility trial;Feedback;Feeling;follow-up;Frequencies;Fright;Goals;improved;innovation;innovative technologies;interest;Intervention;Interview;Legal;Life;Liquid substance;marijuana use;marijuana use disorder;medical specialties;Mental disorders;Methods;mHealth;mhealth interventions;Monitor;Motivation;motivational enhancement therapy;motivational intervention;novel;Opioid;Oral;Outcome Assessment;Participant;Patient Self-Report;Persons;Population Heterogeneity;Primary Care;primary care clinic;primary outcome;Procedures;Process;Process Measure;psychological distress;Qualitative Methods;Quality of life;Race;racial minority population;Randomized, Controlled Trials;recruit;reduced alcohol use;remote delivery;remote grading;remote intervention;Reporting;Research;research and development;retention rate;Risk;satisfaction;screening;secondary outcome;self reliance;Services;sex disparity;Social Environment;social influence;Social outcome;social stigma;Source;substance use;support tools;Surveys;Symptoms;telehealth;Test Result;Testing;Tetrahydrocannabinol;Therapeutic;therapy adherence;therapy development;Time;treatment as usual;Underserved Population;Video Recording;virtual;virtual environment;Vulnerable Populations;web site;Work;young adult;Youth

PROJECT_TITLE: Developing a Telehealth + mHealth Cannabis Use Intervention for Young Adults (MOMENT-V)

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Precision Medicine

ORG_CITY: GAINESVILLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: No Text

PI_NAMEs: COTTLER, LINDA B. (contact);EDER, MILTON

PROGRAM_OFFICER_NAME: MCMASTER, SYDNEY JAYD

PROJECT_TERMS: community engagement;programs;Text

PROJECT_TITLE: All of Us Consortium of CTSA Community Engagement Programs


NIH_SPENDING_CATS: Pediatric;Precision Medicine

ORG_CITY: WASHINGTON

ORG_NAME: DELTA RESEARCH AND EDUCATIONAL FOUNDATION

ORG_STATE: DC

PI_NAMEs: HARRIS WILLIAMS, KIMIYO Y;THOMAS, CHERYL MARIE (contact)

PROGRAM_OFFICER_NAME: BLACKBURNE, FAITH THERESA

PROJECT_TERMS: Adult;African American;Biomedical Research;Child;Clinical Trials;cohort;Communities;Data Set;Enrollment;Health;Historically Black Colleges and Universities;Individual;Interdisciplinary Study;Parents;programs;Research;Research Personnel;Research Project Grants;School-Age Population;United States;volunteer

PROJECT_TITLE: DREF Research Matters: Creating Possibilities to Achieve Health and Wellness for All of Us Through Community and Researcher Engagement, Enrollment and Retention


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Breast Cancer;Cancer;Diabetes;Prevention;Women's Health Research

ORG_CITY: DETROIT

ORG_DEPT: CHEMISTRY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Public Health Relevance This proposal aims to determine key mechanisms by which altered cellular metabolism drives disease risk, for instance an up to 28% higher rate of breast cancer incidence in patients with type 2 diabetes. Our innovative solutions map events driven by the metabolism-linked protein modification O-GlcNAc with control over cellular timing and the cellular location in which they operate, filling critical existing gaps in knowledge that do not track spatiotemporal mechanistic aspects. We apply our “time and space” cellular tools to the oncogenic transcription factor NFkB to determine actionable therapeutic strategies for metabolism-linked cancer risk and establish a well-rounded research program to target fundamental and applied mechanisms able to link metabolism with human disease risks.

PI_NAMEs: FEHL, CHARLIE  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Address;Awareness;Biology;Breast Cancer Risk Factor;cancer risk;Cell Nucleus;Cells;Cellular Metabolic Process;Chemicals;Collaborations;Communities;Cytosol;Development;Diabetes Mellitus;diabetic patient;Disease;Disease Pathway;disorder risk;Drug Targeting;Endoplasmic Reticulum;Ensure;Event;Funding;Glucose;Glycobiology;Goals;Hour;Human;human disease;Hyperglycemia;Incidence;Industrialization;Inflammation;innovation;Insulin;insulin signaling;Knowledge;Label;Laboratories;Lead;Link;link protein;Location;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;Metabolic;Metabolic Diseases;Metabolism;Methods;Modification;Molecular;Molecular Probes;Morphologic artifacts;Movement;NF-kappa B;Non-Insulin-Dependent Diabetes Mellitus;Nutrient;Oncogenic;Output;Pathology;Patients;Photochemistry;Physiologic pulse;Physiological;Physiology;Post-Translational Protein Processing;Process;programs;Proteins;public health relevance;Publishing;Real-Time Systems;Reporting;Research;Resolution;Scientist;Sialic Acids;Signal Transduction;spatiotemporal;Specialist;Stress;Subcellular Spaces;success;sugar;System;technology development;Therapeutic;Time;tool;tumor metabolism;United States National Institutes of Health;Work

PROJECT_TITLE: Spatiotemporal tools to interrogate O-GlcNAc functions in cellular signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: TUCSON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: The All of Us Research Program has created a national research dataset that is unprecedented in size and scope to advance precision medicine. This project aims to enable researchers to effectively and rigorously utilize All of Us data for scientific discovery. The proposed research is relevant to public health because it has the potential to accelerate biomedical research, generate new knowledge, and reduce the public health burden of a wide variety of diseases. Thus, the proposed projects are relevant to the part of the NIH mission that pertains to a focus on improving population health and supporting rigorous, reproducible, and unbiased research.

PI_NAMEs: KARNES, JASON HANSEN (contact);MORENO, FRANCISCO A;SOLOMON, TESHIA G. ARAMBULA;SUBBIAN, VIGNESH

PROGRAM_OFFICER_NAME: ALFARANO, ALEXANDRIA SKYE

PROJECT_TERMS: Acceleration;Achievement;Address;All of Us Research Program;Area;Arizona;Automobile Driving;Awareness;biomedical informatics;Biomedical Research;career;cloud based;Communities;community based participatory research;Coupled;Data;Data Set;data standards;Decision Making;Dedications;Development;Ecosystem;education resources;empowerment;Ensure;Equity;experience;flexibility;Funding;Generations;Grant;Health equity research;Hispanic-serving Institution;Incentives;Informatics;innovation;Institution;interest;Investments;literacy;Mentors;outreach;Participant;Peer Review;Pharmacogenomics;Positioning Attribute;precision medicine;programs;Publications;Recommendation;recruit;Research;research and development;Research Personnel;Research Project Grants;Resources;scientific organization;success;Training;Underrepresented Populations;Universities;Work

PROJECT_TITLE: Precision Medicine for All of Us Researchers’ Collective


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: NEW YORK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: In this one-year project, we will create a digital twin for rectal cancer treatments by extending our radiobiology- based tumor simulation model. We will conduct this project using personnel, tools, and data readily available to us, including a prospectively collected, outcome-annotated institutional rectal cancer cohort consisting of patients treated with total neoadjuvant therapy, with tumor genomic assay data, including either long-course chemoradiotherapy or with short-course radiotherapy. In addition to the implications for rectal cancer treatment in general, the results of this project could be particularly useful in establishing a digital twin model for use as a baseline component of our parent ImmunoRad ROBIN U54 rectal cancer analyses.

PI_NAMEs: DEASY, JOSEPH O;FORMENTI, SILVIA C. (contact);WEICHSELBAUM, RALPH R

PROGRAM_OFFICER_NAME: VIKRAM, BHADRASAIN

PROJECT_TERMS: Acceleration;Address;Archives;Artificial Intelligence;automated segmentation;bioinformatics tool;Biological;Biological Assay;Biology;Biopsy;Blood;Blood Vessels;Budgets;Cancer Patient;cancer radiation therapy;cancer site;cancer therapy;Carrying Capacities;cell killing;Cells;chemoradiation;chemotherapy;Clinic;Clinical;Clinical Data;Clinical Investigator;Clinical Trials;clinically relevant;cohort;Collaborations;Colonoscopy;Common Neoplasm;Communities;Complex;Computer software;cone-beam computed tomography;Consent;COVID-19;Cytostatics;cytotoxic;Data;data acquisition;data harmonization;data sharing;Dedications;deep learning;Dependence;digital data;digital twin;Discipline;Disease;DNA Sequence Alteration;Doctor of Medicine;Doctor of Philosophy;Dose;dose individualization;Environment;Europe;experience;Faculty;FDA approved;Feces;Fertilization;Foundations;Fractionation;Funding;Future;genomic data;genomic variation;Genomics;Grant;Hand;Harvest;Human Resources;Hypoxia;Image;imaging modality;Imaging Techniques;Immune;Immune system;Immunity;Immunophenotyping;improved outcome;Institution;interest;International;Ionizing radiation;Lead;longitudinal analysis;lymph nodes;Magnetic Resonance Imaging;Malignant Neoplasms;Maps;Methodology;microbiome;Modeling;models and simulation;multiple omics;Nature;Neoadjuvant Therapy;neoplastic cell;next generation sequencing;Non-Small-Cell Lung Carcinoma;novel;Operative Surgical Procedures;Organ;Outcome;Oxidative Stress Induction;Parents;Patients;Pattern;Peripheral Blood Mononuclear Cell;Phase;Postdoctoral Fellow;Preparation;Procedures;Proliferating;prospective;Radiation;radiation effect;Radiation Oncology;Radiation therapy;Radiobiology;radiomics;Rectal Cancer;Rectum;Regulation;Research;Research Personnel;response;Sampling;Scientist;sequencing platform;simulation;Site;Sorting;Specimen;standard care;Standardization;Structure;synergism;Testing;Time;Tissues;tool;Training;Translations;treatment response;tumor;tumor growth;Tumor Volume;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: A Digital Twin for rectal cancer to guide adaptive radiotherapy


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Deficits in effortful control (the top-down control of self-regulation) represent a major transdiagnostic risk factor for childhood psychopathology, yet associations between the caregiving and neurobiological mechanisms that disrupt the early development of effortful control are unknown. This prospective longitudinal study investigates the development of effortful control in the first three years of life, examining the extent that maternal mind- mindedness (accurately interpreting infant behavior as resulting from infant mental states), as a specific yet critically understudied component of parenting, alters infant brain structural and functional connectivity in key brain regions underlying effortful control development. Findings will elucidate maternal mind-mindedness as a modifiable component of the caregiving environment that can be targeted in early parent-child interventions to enhance infant brain connectivity and support development of effortful control to reduce risk for developmental psychopathology.

PI_NAMEs: LEAN, RACHEL EMMA (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: 2 year old;3 year old;Address;Affect;Age;Anxiety;Attention;Award;Behavior;Behavioral;behavioral response;Birth;Brain;Brain region;Caregivers;caregiving;caregiving research;Child;Child Development;Child Psychiatry;Child Rearing;Childhood;Code;Cognitive deficits;cohort;design;Development;Diagnostic;Diffusion;Diffusion Magnetic Resonance Imaging;early childhood;Emotional;Environment;Evaluation;follow-up;Foundations;Functional disorder;Functional Magnetic Resonance Imaging;functional MRI scan;Goals;high risk infant;Impairment;improved;infancy;Infant;Infant Behavior;Infant Development;Inferior;Informal Social Control;innovation;Institution;Intervention;Investigation;Life;Life Stress;Link;longitudinal, prospective study;Magnetic Resonance Imaging;maternal depression;Measures;Mediating;Mediator;Mental Depression;Mental disorders;mental state;Methods;Mind;Mothers;MRI Scans;multidisciplinary;neonate;neurobiological mechanism;neuroimaging;Neuropsychology;Neurosciences Research;novel;Parent-Child Relations;Parents;Parietal;Perinatal;peripartum depression;Poverty;preventive intervention;Process;prospective;Protocols documentation;Psychologist;Psychopathology;psychosocial;Published Comment;Regulation;Research;response;Rest;Risk;Risk Factors;Risk Reduction;Scheme;School-Age Population;Self Assessment;Shapes;skills;Source;Standardization;Stress;Structure;Testing;Time;Training;verbal;white matter

PROJECT_TITLE: Investigating Links Between Dysfunctional Parenting and Infant Brain Connectivity on Development of Effortful Control


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: LA JOLLA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative In the parent award, we aim to improve image-guidance of pediatric cardiac catheterizations by developing a closed-loop, multi-beat data synthesis reconstruction pipeline. Recently, our group, led by the Candidate for supplemental support, has developed a fast, inline approach to score image quality. In this supplement, we request support for this current graduate student to pursue the use of image quality as a metric to extend our imaging framework and further their graduate training.

PI_NAMEs: CONTIJOCH, FRANCISCO J (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: anatomic imaging;Biomedical Engineering;Cardiac;Cardiac Catheterization Procedures;Cardiology;Catheterization;Childhood;Clinical;clinical care;Collaborations;Data;data acquisition;Development;Devices;Doctor of Philosophy;doctoral student;experience;Fluoroscopy;graduate student;Image;Image Analysis;image guided;image reconstruction;improved;in silico;In Vitro;in vivo;Laboratories;Magnetic Resonance Imaging;Morphologic artifacts;Motion;multidisciplinary;novel;parent project;Patient Care;Patients;pediatric cardiologist;Physicians;Principal Investigator;Publications;Publishing;Radiology Specialty;reconstruction;Research;respiratory;Roentgen Rays;Sampling;Scientist;soft tissue;symposium;Testing;Time;Training;Training Activity;Training Programs;Training Support;Visualization;Work

PROJECT_TITLE: Improved MRI guidance of pediatric catheterization via autonomous multi-beat data synthesis

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ORG_CITY: BERKELEY

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative: Consistent with its fundamental roles in neurobiology and cell development, complete knockouts of dynein stop the entire MT transport machinery and inhibit mitosis. Mutations that alter the processivity or velocity of cytoplasmic dynein movement lead to pathogenesis of motor neuron degeneration, Alzheimer’s disease, ALS, lissencephaly and schizophrenia, and the absence of axonemal dynein arms causes male infertility and primary ciliary dyskinesia. A detailed investigation of dynein’s mechanochemical cycle and its regulation by dynactin and cargo adaptor proteins will significantly contribute to our understanding of how points mutants in the dynein/dynactin complex contribute to human disease and the development of specific chemical inhibitors of dynein function for the treatment of these diseases in future studies.

PI_NAMEs: YILDIZ, AHMET  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Adaptor Signaling Protein;Alzheimer's Disease;arm;Autophagosome;Behavior;Binding;Binding Sites;biophysical analysis;Cells;Chemicals;Cilia;cilium motility;cofactor;Complex;Cryoelectron Microscopy;Cytoplasm;Development;Disease;dynactin;Dynein ATPase;Exclusion;Exhibits;Future;Generations;Geometry;Goals;human disease;In Vitro;in vivo;inhibitor;Intracellular Transport;Investigation;Kinesin;Knock-out;Lead;Liquid substance;lissencephaly;Male Infertility;Microtubule-Associated Proteins;Microtubules;Mitochondria;Mitosis;Mitosis Inhibition;Modeling;Molecular;molecular imaging;Motility;Motor;motor neuron degeneration;Movement;mutant;Mutation;Neurobiology;Neuropathy;optic trap;optical traps;Pathogenesis;Physiological;Play;predictive modeling;Primary Ciliary Dyskinesias;programs;Recombinants;reconstitution;Regulation;Research;retrograde transport;Role;Schizophrenia;simulation;single molecule;Slide;success;System;tau Proteins;Testing;Tetrahymena;Tubulin;vesicle transport;Work

PROJECT_TITLE: The Mechanism and Regulation of Cytoplasmic and Ciliary Dyneins

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Social Determinants of Health

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE This real-world efficacy study (NIH stage 3) will determine whether overcoming common information and communication technology (ICT) access barriers (i.e., to stable cellular phone, broadband internet, and navigation) can enhance community services' ability to address social needs and improve health outcomes for socioeconomically disadvantaged populations. In a randomized controlled trial of 600 patients seeking care in urban, suburban, and rural emergency departments, we will collaborate with community and digital service providers and leverage existing protocols and scalable health information technology to evaluate the integration of ICT access and digital navigation assistance. By facilitating stable cellphone access and digital navigation within our screening and referral infrastructure, we aim to gain critical insights into whether these interventions lead to more successful connections to social services and improved health outcomes for disadvantaged populations.

PI_NAMEs: WALLACE, ANDREA SCHNEIDER (contact)

PROGRAM_OFFICER_NAME: BOWEN, MARY ELIZABETH

PROJECT_TERMS: Accident and Emergency department;Address;Adoption;Anxiety;arm;Automobile Driving;care seeking;Cellular Phone;Characteristics;Clinical;Clinical Services;Communication;Communities;community collaboration;community engagement process;community partners;Community Services;Computer software;cost;Data;Devices;digital;digital tool;Disparity population;Economically Deprived Population;efficacy study;Electronic Mail;Emergency Department patient;Emergency department visit;Equity;experience;follow-up;Food;Fostering;Frequencies;global health;Goals;Health;Health behavior;health disparity;health disparity populations;health equity;health information technology;Health Services Accessibility;Healthcare;Healthcare Systems;Home;Household;Housing;improved;Individual;Infrastructure;insight;Internet;Intervention;Interview;Lead;Life;Link;literacy;Loneliness;meetings;Mental Depression;National Institute of Nursing Research;Outcome;outreach;outreach services;patient engagement;Patients;Persons;Play;Policies;Poverty;programs;prospective;Protocols documentation;Public Health;Quality of life;Randomized;Randomized, Controlled Trials;Reduce health disparities;Reporting;Research;Resource Allocation;Resources;Role;Rural;satisfaction;screening;service providers;Services;social;Social Environment;social health determinants;Social support;Social Work;socioeconomic disadvantage;Spanish/English;suburb;Technology;Telephone;Testing;Transportation;treatment arm;treatment as usual;United States National Institutes of Health;Utah;Visit

PROJECT_TITLE: Enhanced Digital Access to Bridge Social Needs and Reduce Health Disparities: The e-SINCERE Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZNR1 REV-N (07)]


NIH_SPENDING_CATS: Genetics;Hematology;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PALO ALTO

ORG_NAME: PALO ALTO VETERANS INSTIT FOR RESEARCH

PHR: Narrative The proposed research is relevant to public health because it will identify new approaches to treating a group of blood disorders called myeloproliferative neoplasms (MPN), that arise due to mutations in the gene, calreticulin (CALR). MPN is characterized by excess blood cell production, an increased risk of blood clotting and bleeding, in addition to increased risk of transformation to acute leukemia and no curative treatment options apart from stem cell transplantation. Thus, the proposed research is relevant to the part of the NIH’s mission that pertains to understanding mechanisms of disease with the goal of identifying better, more specific treatment options, thus reducing the burden of human disease.

PI_NAMEs: MULLALLY, ANN  (contact)

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: Acute leukemia;Acute Myelocytic Leukemia;Biochemical;Bioinformatics;Biology;Blood Cells;Blood coagulation;Blood typing procedure;Bone Marrow;calreticulin;Cells;Chemicals;Chromatin;Clinic;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;curative treatments;Data;Dependence;Development;Disease;Disease Progression;Dissection;Event;FDA approved;functional genomics;Genes;Genetic;glycosylation;Goals;Hematological Disease;Hematopoietic;Hematopoietic stem cells;Hemorrhage;histone modification;Human;human disease;In Vitro;in vivo;inhibitor;innovation;insight;JAK2 gene;Knock-in Mouse;Knock-out;Knowledge;Mass Spectrum Analysis;Measures;Mission;Molecular;mouse model;multicatalytic endopeptidase complex;mutant;Mutate;Mutation;Myelofibrosis;Myeloproliferative disease;Natural History;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Oncogenic;Outcome;palliative;Pathway interactions;Patients;pharmacologic;Phenotype;Production;Prognosis;prognostic;Property;Proteasome Inhibition;Protein Biosynthesis;Protein Secretion;Proteomics;proteostasis;Public Health;Publishing;Reagent;Repression;Research;Risk;screening;single cell sequencing;Stem cell transplant;Testing;Therapeutic;thrombocytosis;Transcriptional Activation;transcriptome;Translating;translational impact;treatment strategy;United States National Institutes of Health;whole genome;Work

PROJECT_TITLE: Functional and Molecular Dissection of Mutant Calreticulin in Myeloproliferative Neoplasms

STUDY_SECTION: MCH

STUDY_SECTION_NAME: Molecular and Cellular Hematology Study Section[MCH]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Prevention

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PI_NAMEs: ALTMAN, JOHN  (contact)

PROJECT_TERMS: biomedical resource;Communicable Diseases;Communities;Core Facility;Databases;Disease;HIV/AIDS;Immune;Immune response;improved;Major Histocompatibility Complex;Mediating;National Institute of Allergy and Infectious Disease;novel therapeutics;Peptides;Performance;Prevention;programs;Public Health;Reagent;repository;Research;research and development;Research Personnel;Research Support;Technology;Therapeutic Agents;United States National Institutes of Health;vaccine development

PROJECT_TITLE: NIH TETRAMER CORE FACILITY (HIV/AIDS)


PROJECT_TERMS: Basic Science;biomedical resource;Communicable Diseases;Communities;Core Facility;Databases;Disease;Immune;Immune response;improved;Mediating;National Institute of Allergy and Infectious Disease;novel therapeutics;Prevention;Public Health;Reagent;repository;Research;Research Personnel;Research Support;Therapeutic Agents;United States National Institutes of Health;vaccine development

PROJECT_TITLE: NIH TETRAMER CORE FACILITY FOR INFECTIOUS DISEASES


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Prevention

PROJECT_TERMS: Basic Science;biodefense;biomedical resource;Communities;Core Facility;Databases;Disease;Emerging Communicable Diseases;Immune;Immune response;improved;Mediating;National Institute of Allergy and Infectious Disease;novel therapeutics;Prevention;Public Health;Reagent;repository;Research;Research Personnel;Research Support;Therapeutic Agents;United States National Institutes of Health;vaccine development

PROJECT_TITLE: NIH Tetramer Core Facility


FUNDING_MECHANISM: INTERAGENCY AGREEMENTS

NIH_SPENDING_CATS: Bioengineering;Cancer;Machine Learning and Artificial Intelligence

ORG_NAME: NATIONAL CANCER INSTITUTE

PROJECT_TERMS: Advanced Development;Agreement;anti-cancer research;Biomedical Research;Cancer Biology;Collaborations;Communities;Computer Models;Computer software;Data;Department of Energy;Development;Disease;Ecosystem;Foundations;Funding;Future;Goals;Machine Learning;Malignant Neoplasms;Modeling;National Cancer Institute;next generation;Patient Care;Patient-Focused Outcomes;Patients;predictive modeling;Private Sector;Research;Research Activity;Resources;simulation;Source;Strategic Planning;Technology;Testing;tool;Work;working group

PROJECT_TITLE: DOE Collaboration


NIH_SPENDING_CATS: Burden of Illness;Cancer;Prevention;Social Determinants of Health

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PI_NAMEs: CHARLTON, MARY  (contact)

PROJECT_TERMS: Annual Reports;anti-cancer research;Cancer Control;Cancer Patient;cancer statistics;Data;Diagnosis;Disease;Geography;Incidence;Infrastructure;insight;Malignant Neoplasms;Monitor;National Cancer Institute;Patients;Population;Prevalence;SEER Program;Social Characteristics;Subgroup;Time;treatment pattern;trend

PROJECT_TITLE: SEER CORE INFRASTRUCTURE SUPPORT


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: LAFAYETTE

ORG_NAME: UNIVERSITY OF LOUISIANA AT LAFAYETTE

ORG_STATE: LA

PI_NAMEs: VILLINGER, FRANCOIS  (contact)

PROJECT_TERMS: AIDS prevention;AIDS Vaccines;Area;Breeding;clinical efficacy;Development;Evaluation;evaluation/testing;flexibility;germ free condition;HIV vaccine;Housing;Immune response;immunogenicity;Macaca mulatta;Maintenance;Modality;Modeling;Mucosal Immune Responses;National Institute of Allergy and Infectious Disease;nonhuman primate;operation;preclinical evaluation;preclinical study;prevent;Prevention Research;Prevention strategy;programs;research clinical testing;Research Personnel;Resources;Risk;Testing;United States National Institutes of Health;vaccine efficacy;vaccine evaluation;Vaccine Research;vaccine trial;Vaccines;Virus;Virus Diseases

PROJECT_TITLE: Simian Vaccine Evaluation Unit: Operation of a Nonhuman Primate Breeding Colony


PROJECT_TERMS: AIDS prevention;AIDS Vaccines;Area;Breeding;Caring;clinical efficacy;Development;Evaluation;evaluation/testing;flexibility;HIV vaccine;Housing;Immune response;immunogenicity;Maintenance;Modality;Modeling;Mucosal Immune Responses;National Institute of Allergy and Infectious Disease;nonhuman primate;preclinical evaluation;preclinical study;prevent;Prevention Research;Prevention strategy;programs;Quarantine;research clinical testing;Research Personnel;Resources;Risk;Testing;United States National Institutes of Health;vaccine efficacy;vaccine evaluation;Vaccine Research;vaccine trial;Vaccines;Virus;Virus Diseases

PROJECT_TITLE: Simian Vaccine Evaluation Unit: Maintenance of Nonhuman Primates


ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

PI_NAMEs: AYE, PYONE  (contact)

PROJECT_TERMS: AIDS prevention;AIDS Vaccines;Area;Blood;Breeding;Cells;clinical efficacy;Data;Databases;Development;Evaluation;evaluation/testing;flexibility;HIV vaccine;Housing;Immune response;immunogenicity;Maintenance;Modality;Modeling;Mucosal Immune Responses;Mucous Membrane;National Institute of Allergy and Infectious Disease;nonhuman primate;Occupational activity of managing finances;Plasma;preclinical evaluation;preclinical study;prevent;Prevention Research;Prevention strategy;programs;Reporting;research clinical testing;Research Personnel;Resources;Risk;Sampling;Testing;Tissues;United States National Institutes of Health;vaccine efficacy;vaccine evaluation;Vaccine Research;vaccine trial;Vaccines;Virus;Virus Diseases

PROJECT_TITLE: Simian Vaccine Evaluation Unit: Core Activities - Administrative and Technical Support


ORG_CITY: ROCKVILLE

ORG_NAME: BIOQUAL, INC.

ORG_STATE: MD

PI_NAMEs: LEWIS, MARK  (contact)


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: ANN ARBOR

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: An increase in unexplained persistent respiratory complaints in Gulf War [and Post-9/11 Veterans] has led to mounting concerns that region or conflict specific inhalational hazards cause occult lung injury resulting in chronic small airways inflammation and fibrosis, referred to as deployment-related chronic bronchiolitis (DR-CB) in this proposal. [At present, DR-CB is difficult to diagnose without resorting to surgical lung biopsy. This study will determine whether parametric response mapping, a new CT scan analytical technique, can substantially advance our ability to non-invasively diagnose DR-CB and assess its prevalence in symptomatic SW Asia- deployed Veterans, including those with Gulf War Veterans Illness. The pathogenesis of DR-CB is poorly understood and no treatments for this disorder have been tested in humans or animal models. This proposal utilizes a novel murine model of chronic bronchiolitis to elucidate critical pathologic pathways and potential treatments for this disorder.]

PI_NAMEs: OSTERHOLZER, JOHN  (contact)

PROJECT_TERMS: Academic Medical Centers;Acceleration;active method;Address;Age;airway epithelium;Airway Fibrosis;airway inflammation;Animal Experiments;Animal Model;Apoptotic;Asia;Azithromycin;Biopsy;Bronchioles;Bronchiolitis;CD36 gene;cell injury;Cells;Characteristics;chest computed tomography;Chronic;Chronic lung disease;Classification;Clinical;Clinical Trials;cohort;Collaborations;Conflict (Psychology);Data;Data Set;density;Development;Diagnosis;Disease;Dyspnea;Epithelial Cells;Evaluation;Exercise;Exercise Tolerance;Exposure to;Fibrosis;Future;Gender;Gulf War;Gulf War veteran;hazard;High Resolution Computed Tomography;human model;Human Resources;Impairment;improved;Incidence;Inflammation;Inhalation;Injury;Investigation;Link;Literature;Lung;lung injury;Macrophage;Maps;Measures;Mediating;mouse model;Mus;New Jersey;noninvasive diagnosis;novel;Operative Surgical Procedures;Oxidative Stress;Pathogenesis;Pathologic;Pathway interactions;Phenotype;post 9/11;Prevalence;prevent;Preventive treatment;progenitor;Pulmonary Emphysema;pulmonary function;Pulmonary function tests;radiological imaging;Receptor Cell;Reporting;Research Personnel;Resort;respiratory;Respiratory Signs and Symptoms;respiratory toxin;response;Scanning;severe injury;small airways disease;Soldier;Spirometry;Techniques;technology/technique;Terminal Bronchiole;Testing;Toxin;Transgenic Organisms;translational study;Veterans;War;X-Ray Computed Tomography

PROJECT_TITLE: Advancing Non-Invasive Diagnostics and Treatments of Deployment-Related Chronic Lung Disease in Gulf War Veterans


ORG_CITY: BALTIMORE

ORG_NAME: BALTIMORE VA MEDICAL CENTER

PHR: Traumatic brain injuries occur frequently in combat and are among the leading causes of chronic disabilities in the Veteran population. A well-recognized complication of penetrating brain injury is post-traumatic epilepsy (PTE). The treatment of PTE is often inadequate. The VA has a clear mission to improve the outcome of combat casualties, and to reduce the disabilities of these Veterans currently suffering from complications of Traumatic Brain Injury (TBI). This mission is based on the mandate to provide to provide support to the Department of Defense for the care of combat casualties, and to treat those diseases that are disproportionally represent in the Veteran population. In this project, we seek to further improve and validate a novel PTE animal model which will aid in improving therapies for PTE.

PI_NAMEs: TANG, CHA-MIN  (contact)

PROJECT_TERMS: Anatomy;Animal Model;anti-epileptic agents;Anticonvulsants;Area;Behavioral;Caring;Characteristics;Chronic disability;combat;combat casualty;Complex;Complication;controlled cortical impact;Deafferentation procedure;Department of Defense;disability;Disease;Down-Regulation;drug development;drug discovery;Drug Prescriptions;Drug Screening;Electrodes;Enhancers;Epilepsy;Epileptogenesis;Exclusion;experimental study;Face;Follow-Up Studies;Frequencies;Functional disorder;Hippocampus;improved;improved outcome;in vivo;Injury;Keppra;Lateral;Lead;Lesion;Levetiracetam;Life;Liquid substance;Medical;military veteran;Mission;Modeling;mouse model;Mus;new therapeutic target;novel;Pathologic;Penetrating Brain Injury;Penetration;Percussion;Post-Traumatic Epilepsy;postsynaptic;Preparation;presynaptic;Procedures;Rattus;Reporting;Research;Resources;screening;segregation;Seizures;Slice;Stimulus;Synapses;Testing;Time;Tissues;Traumatic Brain Injury;Validation;Variant;Veterans

PROJECT_TITLE: Validation of a novel animal model of post-traumatic epilepsy


ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: Project Narrative This study aims to improve the health and satisfaction of Veterans with chronic musculoskeletal pain by better understanding the effectiveness of five types of evidence-based complementary and integrative health, which are non-pharmacologic options to treat their pain and comorbid mental health conditions.

PI_NAMEs: TAYLOR, STEPHANIE L (contact);ZELIADT, STEVEN BACCHUS

PROJECT_TERMS: Acupuncture Therapy;addiction;Address;arm;Back;Caring;chiropracty;chronic musculoskeletal pain;Clinical;clinical care;Code;Collaborations;collaboratory;Combined Modality Therapy;comorbidity;comparative effectiveness;comparative effectiveness trial;Complementary Health;Congresses;Data;Data Collection;design;Development;dissemination strategy;Education;Effectiveness;effectiveness clinical trial;effectiveness evaluation;effectiveness measure;Electronic Health Record;evidence base;examination questions;Fatigue;Health;Healthcare;Healthcare Systems;improved;Individual;instrument;Integrative Medicine;Learning;Measurement;Meditation;Mental Health;Methods;mindfulness;Modeling;Musculoskeletal Pain;Neck;Nonpharmacologic Therapy;novel;opioid use;Outcome;Pain;Pain management;Pamphlets;Patient Outcomes Assessments;Patient-Centered Care;Patients;Personal Satisfaction;Phase;physical conditioning;Policies;pragmatic trial;prevent;Primary Care;Process;programs;Provider;Randomized;Recovery;Reporting;Research;Research Personnel;Resources;response;Review Literature;Role;Sampling;satisfaction;Self Care;Site;Standardization;Statutes and Laws;Surveys;Tai Ji;tool;treatment effect;United States National Institutes of Health;Veterans;Yoga

PROJECT_TITLE: Complementary and Integrative Health for Pain in the VA: A National Demonstration Project


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: Narrative Policy makers and policy researchers remain challenged by the rapidly evolving opioid-related public health crisis. The RAND-USC Schaeffer Opioid Policy Tools and Information Center (OPTIC) is a national resource, fostering innovative research in the opioid policy arena and developing and disseminating methods, tools, and information to the research community, policymakers, other stakeholders, and the general public.

PI_NAMEs: STEIN, BRADLEY D (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: 2019-nCoV;Achievement;addiction;Address;Adopted;Advocate;Affect;Area;Buprenorphine;Collection;Communities;COVID-19 pandemic;Data;Data Set;design;Development;Dimensions;Disparity;Disparity population;effective therapy;Effectiveness;Elements;ethnic disparity;Fatality rate;Fentanyl;Fostering;General Population;Goals;Grant;Growth;health inequalities;Illicit Drugs;illicit opioid;improved;Individual;Inequality;Inequity;Information Centers;innovation;Institution;Institutional Racism;Knowledge;Laws;Lead;Methodology;Methods;models and simulation;multidisciplinary;Naloxone;Nature;Opioid;Opioid Analgesics;opioid epidemic;opioid overdose;opioid policy;opioid use disorder;Outcome;overdose death;Overdose reversal;Pain management;Pharmaceutical Preparations;Policies;Policy Maker;Policy Making;Policy Research;Population;Population Heterogeneity;prescription monitoring program;prescription opioid;prevent;Public Health;racial disparity;recovery services;Research;Research Personnel;Resources;Risk;Science;Series;simulation;social;societal costs;Speed;Substance abuse problem;Substance Use Disorder;Swelling;synthetic opioid;Talents;Time;tool;treatment services

PROJECT_TITLE: Center to Advance Research Excellence (OPTIC)


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PITTSBURGH

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative This project will examine how a strategy called storytelling may help to reshape perceptions of brain aging and conditions like dementia in African American communities. The ultimate goals of this work are to combat stigma around brain health and to make infrastructure improvements that will reduce disparities in the detection and diagnosis of dementia among Black and African American adults.

PI_NAMEs: LINGLER, JENNIFER HAGERTY (contact)

PROGRAM_OFFICER_NAME: SANKAR, CHERYSE A

PROJECT_TERMS: acceptability and feasibility;Address;Adult;African American;African American population;Age;Ageism;Aging;aging brain;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease related dementia;American;Amyloid;Awareness;Black American;Black race;blood-based biomarker;Brain;brain health;Bypass;Capital;Caring;Cognitive;cognitive change;Color;combat;Communities;community building;Complex;County;Dementia;Detection;Diagnosis;Discrimination;Disease;Disparity;disparity reduction;Early Diagnosis;Equity;experience;Failure;falls;Fostering;Goals;Health;Health behavior;health disparity;health equity;Health Promotion;Healthcare Systems;high risk;Housing;Impaired cognition;implicit bias;improved;Individual;Infrastructure;innovation;insight;Intercept;Intervention;Labor Unions;late life;Learning;Life;Mainstreaming;Medical;member;minority communities;Minority Groups;Modeling;Multimedia;National Institute on Minority Health and Health Disparities;novel therapeutics;Pathway interactions;perceived discrimination;Perception;Persons;Pharmacy facility;Play;Positioning Attribute;preservation;Public Health;Request for Applications;Research;response;Risk;Route;Science;Sea;Services;Shapes;Social Conditions;social health determinants;social norm;social stigma;Societies;Stigmatization;structural determinants;Structural Racism;Testing;Therapeutic;Time;tool;United States National Institutes of Health;Voice;Work

PROJECT_TITLE: Brain CHEC-AC (Brain and Cognitive Health Equity Campaign for Allegheny County)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-H (50)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Hepatitis;Liver Disease;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Alcoholic hepatitis is a disease of intense liver inflammation and injury caused by heavy alcohol use that can be deadly when severe. Cytokine IL17 may contribute to the development of alcoholic hepatitis by stimulating liver sinusoidal endothelial cells (LSECs) to produce chemokines that drives the inflammatory response. In this study, we will explore the mechanisms of IL17-mediated LSEC activation in alcoholic hepatitis and experiment with novel ways of inhibiting IL17 production by targeting a gene regulatory element.

PI_NAMEs: LIU, MENGFEI  (contact)

PROGRAM_OFFICER_NAME: LIN, LI

PROJECT_TERMS: Affect;alcohol abuse therapy;Alcoholic Hepatitis;Alcoholic Liver Diseases;Antibodies;Autoimmune;Biological;Biological Assay;Cells;chemokine;Chromatin Conformation Capture and Sequencing;chromatin immunoprecipitation;chromosome conformation capture;Clustered Regularly Interspaced Short Palindromic Repeats;CXCL1 gene;cytokine;Data;Development;Discontinuous Capillary;Disease;DNA;Dominant-Negative Mutation;Endothelial Cells;Endothelium;Enhancers;experimental study;Family;gene network;Genes;Guide RNA;Heavy Drinking;Human Resources;IL17 gene;Immune;immune activation;immune cell infiltrate;in vivo;Infiltration;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Interleukin Suppression;Knock-in;Knockout Mice;Knowledge;Ligands;Liver;liver inflammation;liver injury;Liver parenchyma;Mediating;member;Microfluidic Microchips;migration;Mission;Modeling;Molecular Target;Mus;National Institute on Alcohol Abuse and Alcoholism;neutrophil;Neutrophil Infiltration;new therapeutic target;novel;novel therapeutics;Nuclear;paracrine;Paracrine Communication;Pathogenesis;Pathway Analysis;Pathway interactions;Patients;pharmacologic;Phosphorylation;Process;Production;promoter;Protein Isoforms;Regulation;Regulatory Element;response;Role;Sampling;Signal Pathway;Signal Transduction;Small Interfering RNA;Source;synergism;System;T-Lymphocyte;T-Lymphocyte Subsets;Testing;therapeutic target;Threonine;Tissues;TNF gene;Training;transcription factor;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Transgenic Mice;Up-Regulation;Variant;Work

PROJECT_TITLE: IL17 dependent angiocrine signaling drives inflammation in alcohol associated hepatitis


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Telehealth;Violence Research;Youth Violence

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE This project aims to develop and evaluate a digital mental health intervention (DMHI) for adolescents who engage in nonsuicidal self-injury (NSSI) and who are not currently engaged in treatment. I will employ user- centered design methodologies to understand adolescents’ specific needs and preferences, which will guide the development of a scalable, low-intensity DMHI designed to be implemented within the digital offerings of a large mental health advocacy website. The DMHI will support the acquisition and practice of skills to reduce NSSI frequency, and encourage use of external supports to increase further help-seeking among high-risk adolescents who are currently unable or uninterested in accessing traditional psychological treatments.

PI_NAMEs: KRUZAN, KAYLEE PAYNE (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: 17 year old;Adolescence;Adolescent;Advocacy;advocacy organizations;Affect;Attitude;Behavior;career;Collaborations;Conduct Clinical Trials;cost;design;Development;digital;digital delivery;digital intervention;digital mental health;Dissemination and Implementation;Early Intervention;early onset;effectiveness/implementation trial;efficacy testing;Ensure;evidence base;Evidence based practice;Frequencies;Future;Goals;health literacy;help-seeking behavior;high risk;high-risk adolescents;improved;Informal Social Control;Intervention;Link;Mental Health;Methodology;Methods;Modeling;non-suicidal self injury;Pathway interactions;Persons;Population;Positioning Attribute;preference;Prevalence;prevent;Process;psychoeducation;psychologic;Quality of life;Randomized;Randomized, Controlled Trials;Reporting;Research;Research Personnel;Research Project Grants;skills;social stigma;Suicide;Testing;therapy design;Time;Training;usability;user centered design;web site

PROJECT_TITLE: Developing a Digital Intervention for Adolescent Nonsuicidal Self-injury

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Aiming to address the significant mental health needs and barriers to care faced by refugee and immigrant “newcomer” youth in the United States, this project proposes a community-based intervention, “Meet Me on the Pitch,” that integrates behavioral health services, school, and sports programming. The study will apply a mixed-methods approach to develop and refine the intervention, assess its feasibility and acceptability among newcomer youth, and measure the short-term impact of the intervention on mental health outcomes and related social determinants of health including access to healthcare services, school engagement, and social connection of participants. Through rigorous evaluation and authentic community engagement to develop and implement this intervention, this project offers an innovative, upstream approach to transforming behavioral and mental health service delivery and can inform strategies to improve health equity for underserved youth.

PI_NAMEs: DECKER, MARA  (contact)

PROGRAM_OFFICER_NAME: SEAY, JULIA SUSAN

PROJECT_TERMS: acceptability and feasibility;Address;Advisory Committees;Age;Area;Awareness;barrier to care;behavioral health;behavioral health intervention;Caring;Communities;community empowerment;community engagement;community intervention;community violence;Country;COVID-19 pandemic;design;Development;Discrimination;Disparity;Economics;Education;Effectiveness;Emotional;Ensure;ethnic minority population;Evaluation;Evidence based intervention;Evidence based practice;experience;Face;Feedback;flexibility;Focus Groups;Fostering;Fright;Future;Gender;Goals;Health;health care availability;health care delivery;health care service;health disparity;health equity;health equity promotion;health inequalities;Health Services;Health Services Accessibility;Health system;Healthcare;Housing;Immigrant;implementation evaluation;Improve Access;improved;Individual;informant;innovation;insight;Insurance;Intervention;intervention effect;intervention refinement;Interview;Language;Linguistics;Longitudinal Surveys;Low income;low socioeconomic status;Measures;member;Mental Health;Mental Health Services;Methods;model development;Modeling;novel strategies;Outcome;Participant;Pathway interactions;positive youth development;Prevention;primary outcome;Process Assessment;programs;Protocols documentation;Provider;psychologic;racial minority population;Randomized;randomized trial;Randomized, Controlled Trials;recruit;referral services;Refugees;Resources;school health;Schools;screening;secondary analysis;secondary outcome;Self Determination;Service delivery model;Services;skills;Soccer;social;social health determinants;social stigma;Social support;Social Work;Sports;Statistical Data Interpretation;Stress;Surveys;System;Testing;therapy design;therapy development;Training;Trauma;Trust;United States;Youth;youth sports

PROJECT_TITLE: Meet Me on the Pitch: Developing and testing a community-based sports and behavioral health intervention for newcomer youth


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: COLUMBIA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: NARRATIVE The proposed grant will support current and expanded programming by the Tobacco Online Policy Seminar Series in year 2024 and beyond to facilitate the production and sharing of tobacco regulatory sciences knowledge. Thus, the proposed grant is relevant to the part of NIH's mission that pertains to developing fundamental knowledge that will ensure the Nation's capability to prevent diseases and death caused by tobacco use.

PI_NAMEs: PESKO, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: STATON, JILL

PROJECT_TITLE: Tobacco Online Policy Seminar 2024 +

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CTP-T (01)]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Mental Health;Networking and Information Technology R&D (NITRD);Social Determinants of Health;Telehealth

PHR: PROJECT NARRATIVE Globally, linkage to HIV care and retention on antiretroviral therapy are challenges to achieving successful HIV outcomes. mHealth approaches to improving HIV outcomes have not been tailored to older people with HIV in resource-limited settings. We will adapt an evidence-based mHealth intervention and tailor for older people with HIV in the Ukrainian context, test extensively using established methods to ensure a fully functional prototype, and then evaluate feasibility, acceptability, and efficacy of the adapted mHealth intervention.

PI_NAMEs: INGERSOLL, KAREN S;ROZANOVA, JULIA ;SHENOI, SHEELA  (contact);ZEZIULIN, OLEKSANDR

PROGRAM_OFFICER_NAME: NEWSOME, BRAD

PROJECT_TERMS: Acceleration;Address;Administrator;Age;antiretroviral therapy;Appointment;barrier to care;Benchmarking;brief intervention;Caring;CD4 Lymphocyte Count;Cellular Phone;Central Asia;Clinic;Communities;comorbidity;Complex;Conflict (Psychology);Country;craving;Data;Depression screen;depressive symptoms;design;Development;Dropout;Eastern Europe;Education;education resources;effectiveness/implementation trial;efficacy evaluation;Ensure;evidence base;experience;Focus Groups;Future;General Population;handheld mobile device;Health Benefit;HIV;HIV diagnosis;Hybrids;implementation outcomes;Implementation readiness;implementation research;implementation science;improved;Incidence;Income;Individual;informant;innovation;interdisciplinary collaboration;interest;Intervention;Interview;Language;Learning;low and middle-income countries;Medical;medication compliance;Mental Depression;Mental Health Services;Methods;mHealth;mhealth interventions;Modeling;Modification;Moods;mortality;multiple chronic conditions;neglect;Newly Diagnosed;Older Population;Outcome;overtreatment;pandemic disease;peer support;Persons;Phase;pilot test;Policy Maker;Prevention;prototype;psychological distress;Public Health;Randomized;Randomized, Controlled Trials;Recommendation;referral services;Research;research and development;research clinical testing;Research Personnel;Resource-limited setting;response;Russia;screening;Secure;social engagement;Social isolation;social stigma;Social support;Stress;Subgroup;Target Populations;Technology;Terminology;Testing;Time;treatment as usual;Treatment outcome;Ukraine;United States;usability;Viral;Viral Load result;War;Work

PROJECT_TITLE: Adapting mHealth to improve HIV outcomes among older people with HIV in Ukraine

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-J (57)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative Racial and ethnic disparities in food insecurity have persisted over decades and are associated with higher rates of chronic diseases like diabetes and depression, worse chronic disease management, and increased healthcare costs. Aware of the importance of addressing food insecurity to reduce health disparities, there has been a rapid increase in food insecurity interventions, yet evidence to support the effectiveness of these interventions to improve health outcomes remains mixed. Leveraging a clinical-community partnership that has developed a patient-centered, multi-component food insecurity intervention, we will conduct a hybrid effectiveness-implementation study to understand the food interventions’ impact on health outcomes, impact on health care costs and identify implementation strategies for program scale out and sustainment.

PI_NAMEs: BYHOFF, ELENA  (contact)

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: Acute;Address;Adult;Affect;Awareness;Blood Pressure;care costs;Caring;Child;Chronic Disease;Clinical;Communities;community collaboration;community organizations;community partnership;Complex;cooking;cost;Counseling;Data;design;Diabetes Mellitus;dietary;Disease Management;effective intervention;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness/implementation study;Eligibility Determination;Emergency department visit;Enrollment;ethnic disparity;experience;experimental study;Family;Federally Qualified Health Center;flexibility;Food;food insecurity;Glycosylated Hemoglobin;Guidelines;Health;Health Care Costs;health care service organization;health care service utilization;health care settings;health disparity;Healthcare;Hospitalization;Hybrids;Hypertension;implementation evaluation;implementation facilitators;implementation framework;implementation intervention;implementation strategy;improved;Incentives;Individual;innovation;Inpatients;interest;Intervention;intervention delivery;Interview;Investments;Low income;low socioeconomic status;Managed Care;Massachusetts;Medicaid;Medical;Mental Depression;Mental Health;Minority Groups;multi-component intervention;Natural experiment;nutrition;nutrition education;Outcome;Participant;Pathway interactions;patient oriented;patient population;Patient Preferences;Patients;Persons;physical conditioning;Policies;Policy Maker;Population;Population Heterogeneity;Prevention;Program Sustainability;programs;Qualifying;Quasi-experiment;racial disparity;Recording of previous events;Reduce health disparities;screening;Secure;Service delivery model;Services;Site;United States Centers for Medicare and Medicaid Services;uptake;voucher;waiver

PROJECT_TITLE: A clinical-community partnership to understand health impacts of a food insecurity intervention


NIH_SPENDING_CATS: Lung;Pulmonary Fibrosis

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE We will determine the molecular mechanism(s) by which Amino Acid Transporter, SLC7A5 regulate profibrotic TGF-β signaling. We plan to further unravel the downstream cellular, molecular, and metabolic mechanism(s) by which SLC7A5, HIF and antiapoptotic protein, BCl-2 crosstalk in fibrosis and the critical role of SLC7A5 in fibroblast apoptosis and mitophagy. Furthermore, we will investigate whether targeting SLC7A5 will ameliorate severe disease and promote efficient recovery in a therapeutic model of lung fibrosis of both young and aged hosts.

PI_NAMEs: CHOUDHURY, MALAY  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Address;Adult;aged;Aging;aging related;amino acid metabolism;Amino Acid Transporter;Amino Acids;Anchorage-Independent Growth;Apoptosis;Apoptotic;Attenuated;Automobile Driving;BCL2 gene;Biogenesis;Biological;Biomass;Bleomycin;c-myc Genes;cell growth;cell motility;Cell Proliferation;Cells;cellular targeting;Cessation of life;Chemosensitization;Chronic;conditional knockout;cytokine;Data;Defect;Development;Diagnosis;Disease;drug development;effective therapy;Essential Amino Acids;Etiology;Extracellular Matrix Proteins;Family;Feedback;Fibroblasts;Fibrosis;fibrotic lung;FRAP1 gene;Glutamine;Glycolysis;human very old age (85+);idiopathic pulmonary fibrosis;Impairment;improved;in vivo;indium-bleomycin;Induction of Apoptosis;Inhibition of Apoptosis;inhibitor;Interstitial Lung Diseases;Leucine;Lung Diseases;lung repair;Mediating;member;Metabolic;Metabolic Pathway;Metabolism;Mitochondria;Modeling;Molecular;mouse model;Mus;Myofibroblast;Neutral Amino Acids;new therapeutic target;novel;novel therapeutic intervention;Pathogenesis;Patient-Focused Outcomes;pharmacologic;Phenotype;pre-clinical;precision medicine;Predisposition;Process;Production;Proliferating;Protein Biosynthesis;Proteins;Public Health;Pulmonary Fibrosis;pulmonary function;Recovery;Regulation;Resistance;Resolution;Respiratory Failure;response;Role;Signal Transduction;solute;targeted treatment;Therapeutic;Toxic effect;Transforming Growth Factor beta;treatment strategy;uptake

PROJECT_TITLE: Targeting the Amino Acid Transporter SLC7A5 for Pulmonary Fibrosis

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Relevance Black patients with advanced cancer who receive cancer care in outpatient settings have unmet spiritual needs, receive care isolated from their faith communities, and are more likely to receive overly aggressive, burdensome, futile, and less hospice, end-of-life care than their white counterparts. This study will provide evidence of how integration of health-care chaplaincy into outpatient oncology clinics, and its linkage with faith community spiritual care providers, promotes spiritual wellness and results in higher quality end-of-life decision-making and care for Black patients with advanced cancer.

PI_NAMEs: ASTROW, ALAN BENNETT;MACIEJEWSKI, PAUL K (contact);PRIGERSON, HOLLY GWEN

PROGRAM_OFFICER_NAME: LONG, SYLVIA ELISABETH

PROJECT_TERMS: Address;Admission activity;Advance Care Planning;Advanced Malignant Neoplasm;Affect;African American;Ambulatory Care Facilities;arm;Belief;black patient;Black race;cancer care;Cancer Patient;care providers;Caring;Cessation of life;Chaplain;Clinic;commune;Communities;connected care;Consensus;coping;Data;Decision Making;Distant;Distress;end of life;end of life care;end of life outcomes;ethnic minority;experience;Faith;Healthcare;Hospice Care;hospice environment;hospice utilization;implementation barriers;implementation intervention;Inequity;Intensive Care Units;Intervention;intervention effect;Interview;Logic;Malignant Neoplasms;Mediating;Medical;meetings;member;Methods;minority patient;Oncology;Outcome;Outpatients;Pain;Participant;Patients;post intervention;Prayers;primary outcome;Quality of life;racial disparity;racial minority;Randomized;Randomized, Controlled Trials;Readiness;Religion;Religion and Spirituality;Reporting;Risk;secondary outcome;social deprivation;Spiritual care;Spiritual well-being;Spirituality;System;Trust

PROJECT_TITLE: Bridge to Better End-of-Life Care for Black Patients with Cancer: Connecting Healthcare Chaplains with Spiritual Care Providers in Faith Communities


NIH_SPENDING_CATS: Bioengineering;Cancer;Lung;Lung Cancer

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: NARRATIVE Darwinian evolution drives the emergence of resistance to targeted therapy in cancer. We propose to use results from our in vitro evolutionary game assay to parameterize a computer model to allow us to predict 3-dimensional dynamics on clinically relevant timescales. Further, we will extend our assay to function in vivo, allowing the community to test mathematically derived evolutionary therapy hypotheses in preclinical models.

PI_NAMEs: MARUSYK, ANDRIY ;SCOTT, JACOB GARDINIER (contact)

PROGRAM_OFFICER_NAME: MILLER, DAVID J

PROJECT_TERMS: 3-Dimensional;abiraterone;actionable mutation;Address;anti-cancer research;Antibiotic Resistance;Automobile Driving;Biological;Biological Assay;Biological Process;Biology;Cancer Model;cancer therapy;Clinic;Clinical;Clinical Medicine;clinical translation;Clinical Trials;clinically relevant;Code;Communities;Complex;Computer Models;Data;design;Disease;Ecosystem;Epidermal Growth Factor Receptor;Evolution;Exhibits;experience;Extinction;Favorable Clinical Outcome;Fisheries;Game Theory;Generations;Genes;Glean;Grain;Growth;Heterogeneity;in silico;In Vitro;in vitro Model;in vivo;inhibitor;insight;interdisciplinary approach;Intuition;invention;Life;Literature;Malignant neoplasm of prostate;Malignant Neoplasms;mathematical model;Mathematics;Measurement;Measures;Methods;Modeling;multi-scale modeling;mutant;Mutation;neoplastic cell;New Agents;next generation;Non-Small-Cell Lung Carcinoma;novel;pathogen;Patients;Pesticides;Pharmaceutical Preparations;Phase II Clinical Trials;Phenotype;physical science;Population;Population Heterogeneity;Pre-Clinical Model;pressure;Process;Protein Tyrosine Kinase;Proteins;Qualitative Methods;Race;Refractory;Relapse;Research;Resistance;response;Role;spatiotemporal;success;System;targeted cancer therapy;targeted treatment;Testing;Theoretical model;Theoretical Studies;theories;Therapeutic;Therapeutic Intervention;therapy design;Time;tool;Translating;trial design;tumor;two-dimensional;Tyrosine Kinase Inhibitor;Work

PROJECT_TITLE: Extending experimental evolutionary game theory in cancer in vivo to enable clinical translation: integrating spatio-temporal dynamics using mathematical modeling


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homelessness;Infectious Diseases;Mental Health;Post-Traumatic Stress Disorder (PTSD);Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Narrative. The study addresses significant gaps in evidence on the effectiveness and implementation of clinic- community partnerships to improve health outcomes for abused women living with HIV/AIDS by addressing social determinants of health, housing instability and food security.

PI_NAMEs: GLASS, NANCY E (contact);JONES, JOYCE L.

PROGRAM_OFFICER_NAME: WILLIS, LEIGH ANDREW

PROJECT_TERMS: Address;Adherence;Advocacy;African American;AIDS prevention;antiretroviral therapy;Baltimore;Battered Women;Behavior;Black race;Caring;Clinic;community clinic;community organizations;community partners;community partnership;Complex;contextual factors;Counseling;Disclosure;Disproportionately impacts women;Education;Effectiveness;effectiveness evaluation;effectiveness/implementation study;Environment;Equity;experience;food insecurity;food security;future implementation;Health;health care service organization;health care settings;health disparity;health equity;HIV;HIV/AIDS;Housing;housing instability;Hybrids;implementation barriers;implementation facilitation;improved;Individual;Inequity;Intervention;intimate partner violence;Life;Link;Maryland;Measures;medical specialties;member;Mental Depression;Mental Health;older women;Organizational Culture;Outcome;physical conditioning;Policies;Post-Traumatic Stress Disorders;prevention practice;primary outcome;programs;Provider;Psyche structure;Public Health;Qualitative Methods;Reduce health disparities;Reporting;Reproductive Health;Resources;Safety;scale up;School Nursing;Security;Self Efficacy;Services;social;social health determinants;Social Problems;Survivors;Technology;Trauma;treatment adherence;treatment as usual;Treatment Failure;Treatment outcome;Violence;violence exposure;Viral Load result;Visit;Woman;Women's Health

PROJECT_TITLE: Clinic-Community Bridge-to-Care Initiative: Trauma and Violence Informed Care (TVIC) with Women Survivors of Intimate Partner Violence (IPV) and Living with HIV/AIDS


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Precision Medicine

ORG_CITY: MADISON

ORG_NAME: MORGRIDGE INSTITUTE FOR RESEARCH, INC.

ORG_STATE: WI

PHR: PROJECT NARRATIVE Improved treatment strategies for patients with cancer require enhanced tools to better predict patient response, model clonal heterogeneity, and identify novel treatment options for individual patients. This study validates accessible optical imaging tools and heterogeneity analysis to assess patient-derived tumor organoids for this purpose. These insights could ultimately lead to improved treatment options for cancer patients.

PI_NAMEs: DEMING, DUSTIN A;SKALA, MELISSA CAROLINE (contact)

PROGRAM_OFFICER_NAME: SORG, BRIAN S

PROJECT_TERMS: 3-Dimensional;Architecture;Cancer Patient;cancer type;Cell Communication;Cell Line;Cells;chemotherapy;Clinic;Clinical;clinical predictors;Clonal Evolution;Coenzymes;colon cancer patients;Colorectal Cancer;colorectal cancer treatment;Complex;cost;Culture Techniques;Development;disease model;drug candidate;drug development;Drug resistance;Drug Screening;Dyes;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Evolution;experience;Fluorescence;Genetic;Genetic Heterogeneity;Goals;Heterogeneity;high throughput screening;Hour;Human;human model;Image;Image Analysis;Imaging Device;Imaging Techniques;improved;in vivo;individual patient;insight;Label;Laboratories;Maintenance;Malignant Neoplasms;Measures;Metabolic;metabolic imaging;metastatic colorectal;Methods;Microscopy;Modeling;Molecular;Monitor;Multivariate Analysis;non-invasive imaging;novel;novel drug combination;novel therapeutics;optical imaging;Optics;Organoids;Patient imaging;patient response;Patients;Pharmaceutical Preparations;Photons;predicting response;Prediction of Response to Therapy;prevent;Reader;Reagent;Receptor Inhibition;Resistance;response;sample fixation;Sampling;screening;targeted treatment;Techniques;Technology;Testing;Time;tool;Translational Research;translational study;treatment planning;treatment response;treatment strategy;tumor;tumor DNA;two-photon;validation studies;Work

PROJECT_TITLE: Functional optical imaging for rapid, label-free predictions of treatment response and clonal evolution in patient-derived cancer organoids


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Gigantism is a childhood disease that causes excessive growth with serious side effects. While there are drugs that can treat the symptoms of gigantism, they have side effects, are expensive, and require repeated injections. I propose to study at a molecular level how these drugs work so that better therapies can be developed.

PI_NAMEs: ROBERTSON, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: PILEGGI, ANTONELLO

PROJECT_TERMS: Agonist;analog;antagonist;Antineoplastic Agents;Arrestins;Behavior;Binding;Biochemical;Biological Assay;Bioluminescence;Blindness;Cell Line;Cells;Cellular Assay;Child;Childhood;clinically relevant;Complex;cost;Cryoelectron Microscopy;Data;Data Collection;design;Development;developmental disease;Diabetes Mellitus;differential expression;Disease;drug development;Energy Transfer;Exhibits;Family member;FDA approved;Free Energy;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Gigantism;Goals;Growth;GTP-Binding Proteins;Height;Heterotrimeric GTP-Binding Proteins;improved;Injections;insight;Insulin;Intervention;Knowledge;Ligands;Modeling;Molecular;Molecular Conformation;molecular dynamics;Molecular Weight;nanobodies;Neuroendocrine Tumors;next generation;Octreotide;Operative Surgical Procedures;Oral;Pathway interactions;peptide analog;peptide drug;Peptides;Pharmaceutical Preparations;Pharmacodynamics;Pharmacologic Substance;Pharmacology;Pituitary Gland;Pituitary Gland Adenoma;Production;Property;Protein Biochemistry;receptor;Receptor Activation;receptor coupling;Receptor Signaling;recruit;reduce symptoms;Resolution;Running;side effect;Signal Transduction;simulation;skills;small molecule;small molecule therapeutics;Social isolation;Somatostatin;Somatostatin Receptor;Somatotrophin increased;Somatotropin;SSTR1 gene;SSTR2 gene;SSTR3 gene;Structure;success;symptom treatment;Symptoms;Testing;Therapeutic Effect;Therapeutic Uses;Training;Transmembrane Domain;tumor;Work

PROJECT_TITLE: Improved Targeting of Somatostatin Receptors for Pediatric Conditions

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Lung;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative The proposed project, Housing, Environment, And Living Conditions for Transformed Health (HEALTHe Birmingham), will seize a once-in-a-generation opportunity to determine the effectiveness of large-scale, multicomponent social determinants of health (SDoH) initiatives in reducing health disparities through improved housing and neighborhood conditions and indoor air quality. We will compare the cost-effectiveness, translation potential, and health equity implications of specific intervention components for lung health and chronic disease risk. This innovative approach will help us fill a knowledge gap regarding the potential of SDoH interventions to improve health equity.

PI_NAMEs: BATEMAN, LORI BRAND;OATES, GABRIELA R (contact)

PROJECT_TERMS: Address;Affect;Area;authority;Award;Behavioral;Biological;Black race;built environment;Businesses;Censuses;Chronic;Chronic Disease;Cities;college;Communities;comparative cost effectiveness;comparison control;Computerized Medical Record;Cost Analysis;cost effectiveness;Cost Effectiveness Analysis;Crime;Data;Diabetes Mellitus;Diet;Disease;disorder risk;Disparity;Economic Burden;economic evaluation;Education;effectiveness evaluation;endothelial dysfunction;Environment;Environmental Exposure;Environmental Pollution;Evaluation;evidence base;Exposure to;Federal Government;Focus Groups;General Population;Generations;Grant;Green space;Health;Health behavior;health disparity;health equity;health inequalities;Health Promotion;Heart Diseases;Housing;Human;implementation efforts;implementation science;improved;indoor air;Indoor Air Quality;Industrialization;Inequality;Inflammation;innovation;insight;Instruction;Internet;Intervention;Interview;Investments;Knowledge;Learning;Libraries;Life;Local Government;Location;Lung Diseases;lung health;Modification;Motivation;multiple data types;Natural experiment;Neighborhoods;Outcome;Pathway interactions;Physical activity;physical conditioning;Physical environment;Physiological;Policies;policy implication;Pollution;Privatization;Program Development;prospective;Public Health;Public Housing;Public Policy;Recommendation;Reduce health disparities;Research;Research Personnel;scale up;Site;Sleep;social;social cohesion;social culture;Social Environment;social health determinants;Social Work;stress reactivity;Surveys;Technology;Time;translational potential;Translations;U.S. Department of Housing and Urban Development;Workforce Development


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Chronic Pain;Clinical Research;Infectious Diseases;Natural Products;Neurosciences;Pain Research;Primary Immunodeficiencies;Rare Diseases

ORG_DEPT: DERMATOLOGY

ORG_STATE: MA

PHR: The immune system dysfunction underlying Hidradenitis Suppurativa (HS) is poorly understood and the devastating effects this disease has on quality of life disproportionately affect women and minorities, highlighting a critical health care gap. This study will comprehensively characterize activated immune cells surrounding hair follicles within HS lesions, which represent the pathologic anatomic unit, with spatial precision and test the novel hypothesis that neurogenic inflammation contributes to dysregulated microbe sensing in HS by inducing strong Interleukin (IL)-1, TNF- and IL-17-mediated immune responses. We expect that the proposed studies will identify neurotransmitter inhibitors, many of which are FDA-approved for other indications, as promising treatments for HS.

PI_NAMEs: WHITLEY, SARAH KERN (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Abscess;Affect;Anatomy;antagonist;antimicrobial;Apocrine Glands;Area;Award;Axilla;Biological Products;Biology;botulinum toxin treatment;Botulinum Toxins;Candida albicans;career;CCL2 gene;CD4 Positive T Lymphocytes;Cell Density;Cells;Characteristics;chronic inflammatory disease;Cicatrix;Clinical;clinical care;Clinical Trials;Computational Biology;Cutaneous;cutaneous sensory nerve;cytokine;Data;Dendritic Cells;Dermatology;Development;Disease;Disease remission;disorder control;Disproportionately impacts women;Doctor of Philosophy;Dose;dysbiosis;economic impact;effective therapy;efficacy evaluation;Environment;expectation;experience;experimental study;FDA approved;Fistula;functional outcomes;Gene Expression Profiling;Genomics;Hair follicle structure;Health;Health Care Costs;Healthcare;Hidradenitis Suppurativa;Human;IL17 gene;Immune;immune cell infiltrate;Immune response;Immune System Diseases;Immunology;improved;In Vitro;in vitro Assay;Infection;Inflammation;Inflammatory;inhibitor;innate immune mechanisms;Innate Immune System;innovation;Institution;Interferon Type I;Interleukin-1;interleukin-23;Interleukin-6;K-Series Research Career Programs;Lesion;Ligands;Link;lipoteichoic acid;Macrophage;MAP Kinase Gene;mast cell;Measures;Mediating;Memory;Mental Depression;Mentors;Messenger RNA;Methods;Microbe;microbial colonization;microbial products;Minority;Nerve;Neurobiology;Neurogenic Inflammation;Neuropeptide Receptor;Neuropeptides;neurotransmitter antagonist;next generation sequencing;Nociceptors;novel;Pain;pain relief;pain signal;Pathogenesis;Pathologic;Patient Care;Patients;Population;Production;protein expression;Proteins;Quality of life;randomized controlled design;Randomized, Controlled Trials;receptor expression;Receptor Signaling;Research;response;Scientist;Sensory;Signal Transduction;single-cell RNA sequencing;Sinus;Skin;skin disorder;skin microbiota;Stimulus;Substance P;T cell response;T-Lymphocyte;TACR1 gene;targeted agent;Technology;Testing;Tissues;TLR2 gene;TNF gene;Toll-like receptors;Training;transcriptomics;Translational Research;TRPV1 gene;Universities;Work

PROJECT_TITLE: Targeting cutaneous nociceptors to reduce Type-17 inflammation in hidradenitis suppurativa

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Esophageal Cancer;Genetic Testing;Genetics;Human Genome;Orphan Drug;Precision Medicine;Prevention;Rare Diseases

ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE While millions of Americans harbor the pre-cancerous lesion, Barrett’s esophagus, putting them at elevated risk of esophageal cancer, many will not develop cancer and this progression is poorly understood. This proposed research will provide valuable training to a URM young scientist and determine important contributors to progression and identify how they can be used to predict progression risk.

PI_NAMEs: STACHLER, MATTHEW D (contact)

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: American;Barrett Esophagus;Bile Reflux;Biological Assay;Biological Markers;biomarker panel;cancer genomics;career development;Chronic;clinically significant;Data;Data Analyses;Diagnosis;disorder risk;DNA copy number;Doctor of Philosophy;Dysplasia;Early Diagnosis;Esophageal Adenocarcinoma;Esophageal Tissue;Esophagus;Gastroesophageal reflux disease;Goals;graduate school;high risk;improved;Incidence;Intestines;Laboratories;Lesion;Malignant neoplasm of esophagus;Malignant Neoplasms;Mentors;Mentorship;Methods;Methylation;Molecular;novel therapeutics;Parents;patient stratification;Patients;Persons;premalignant;Preparation;Process;programs;progression risk;Research;Research Personnel;response;Risk;risk stratification;Scientist;Training;Validation

PROJECT_TITLE: Optimization and validation of a biomarker panel for risk stratification in Barrett's esophagus


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Eye Disease and Disorders of Vision;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE Acanthamoeba keratitis is a blinding eye infection with poor treatment options. This study will determine whether steroid eye drops improve vision outcomes and also assess for genetic predictors of severe inflammation using metagenomic sequencing. The study will help ophthalmologists better treat this debilitating eye infection.

PI_NAMEs: KEENAN, JEREMY DAVID (contact)

PROGRAM_OFFICER_NAME: EVERETT, DONALD F

PROJECT_TERMS: Acanthamoeba;Acanthamoeba Keratitis;Adrenal Cortex Hormones;Advocate;Affect;Amoeba genus;anterior chamber;Anti-Inflammatory Agents;Bacteria;Biological;Brazil;Clinical;clinical practice;clinical predictors;Clinical Research;Collaborations;Contact Lenses;Cornea;corneal scar;Cyst;Data;deep sequencing;Development;Diagnosis;Disease Outbreaks;Eligibility Determination;endosymbiont;Enrollment;Equipoise;evidence base;Eye;Eye Infections;Eyedrops;Fright;Gene Expression;Gene Expression Profile;Genes;genetic information;genetic predictors;Growth;Image;Immunologic Factors;improved;In Vitro;India;Infection;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Integration Host Factors;Interleukin Gene;Intervention Trial;Keratoplasty;Knowledge;Masks;metagenomic sequencing;Metagenomics;Natural Immunity;Observational Study;ocular pain;Ophthalmologist;Organism;Outcome;Pain;Participant;pathogen;Pathway interactions;Patients;Perforation;Pharmaceutical Preparations;Placebos;polyhexamethylene biguanide;Polymerase Chain Reaction;prednisolone;primary outcome;Process;Prospective cohort;Prospective Studies;Provider;Quality of life;Randomized;randomized trial;Randomized, Controlled Trials;Recurrence;Regimen;Research Design;Research Personnel;Resolution;response;Risk;Risk Factors;Safety;Sample Size;Scleritis;secondary analysis;secondary outcome;sodium phosphate;Specialist;Specific qualifier value;standard of care;Steroid therapy;Steroids;Swab;Techniques;Therapeutic;Thinness;Time;TLR4 gene;TLR8 gene;topical antiseptic;Topical Corticosteroids;transcriptome;treatment trial;trial design;Ulcer;United Kingdom;United States;Virulence Factors;Vision;Visual;Visual Acuity;Work

PROJECT_TITLE: Parasitic Ulcer Treatment Trial - Diversity Supplement


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Networking and Information Technology R&D (NITRD);Pediatric

ORG_CITY: STANFORD

ORG_DEPT: PEDIATRICS

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative: Pediatric acute care is woefully insufficient among the low- and middle-income countries (LMICs) of sub- Saharan Africa due primarily to provider proficiency gaps. Our proposed studies will determine a strategy for blending a novel adaptive eLearning tool with face-to-face skills learning that includes key elements of repetition and reach to even the most rural providers, and ultimately understand its effect on improving quality of care in LMICs. Together, these results will create a model for provider education that integrates global health perspectives in advancing safe and effective treatment of children, worldwide.

PI_NAMEs: AGWEYU, AMBROSE ;HOKORORO, ADOLFINE ;MEANEY, PETER A (contact)

PROJECT_TERMS: Accreditation;acute care;adaptive learning;Admission activity;Adopted;Africa South of the Sahara;Area;Attitude;Behavior;care outcomes;care providers;Caring;Cellular Phone;Cementation;Certification;Cessation of life;Child;Child Health;Childhood;Clinical;Competence;cost;cost effectiveness;Data;Development;Devices;E-learning;Education;Educational Models;effective therapy;effectiveness study;Electronic Health Record;Electronics;Elements;Engineering;Ensure;Evidence based intervention;Foundations;Future;Geography;global health;Goals;Grant;Guidelines;Health;Health care facility;Health Personnel;Health system;Hospitals;Human Resources;implementation research;implementation strategy;implementation study;improved;Individual;Information Networks;innovation;International;Intervention;Knowledge;Leadership;Learning;Learning Module;Learning Skill;learning strategy;Link;long term memory;low and middle-income countries;Measures;meetings;Methodology;Methods;Modeling;Newborn Infant;novel;Outcome;Paper;Patient-Focused Outcomes;Pattern;Performance;Persons;Phase;Pilot Projects;primary outcome;Process;programs;prospective;Provider;Qualitative Research;Quality of Care;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reaction;recruit;Regional Disease;Resources;response;Rural;scale up;skills;skills training;Standardization;success;System;Tanzania;theories;Time;tool;Training;Work

PROJECT_TITLE: Using adaptive e-learning and smartphones to improve newborn and pediatric admission care outcomes in Mwanza, Tanzania

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-P (56)]


NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: LA JOLLA

ORG_NAME: LA JOLLA INSTITUTE FOR IMMUNOLOGY

PHR: Project Narrative O-GlcNAc is the only known intracellular glycosylation signaling pathway in mammals, and is implicated in nearly every basic biological process from signal transduction and gene expression to cell division and differentiation. Here, we propose to apply new groundbreaking tools we have recently developed to uncover the principles of O-GlcNAc signaling, including its dynamics, how its propagated, and its role in transcriptional control of stem cell differentiation. This Equipment Supplement request for a high- throughput sonication device to lyse cells and nuclei without denaturing protein complexes will enable and facilitate the ongoing success of the projects.

PI_NAMEs: MYERS, SAM ANTHONY (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Adaptor Signaling Protein;Affect;Amino Acid Sequence;Antibodies;Biochemical;Biological Process;Biology;Cell Differentiation process;Cell division;Cell Nucleus;Cell Physiology;Cells;Chemicals;Complex;Coupled;crosslink;Cues;Cytoplasmic Protein;Data;Deposition;Development;Devices;Disease;embryonic stem cell;Equipment;Excision;extracellular;flexibility;follow-up;Fractionation;Funding;Gene Expression;Gene Expression Process;Genomic DNA;glycoproteomics;glycosylation;Health;Hydrolase;innovation;insight;Investigation;Knowledge;mammalian genome;Mammals;Mass Spectrum Analysis;Modification;Monitor;Nature;Nuclear Proteins;O-GlcNAc transferase;parent project;Peptides;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;pluripotency;Post-Translational Protein Processing;programs;protein complex;Proteins;Reagent;Research;Resolution;response;Role;Sampling;Serine;Signal Pathway;Signal Transduction;Site;Sonication;stem cell differentiation;success;Technology;Threonine;Tissues;tool;Totipotency;Transcriptional Regulation

PROJECT_TITLE: Elucidating the signaling and protein interaction networks of the O-GlcNAc transferase during embryonic stem cell state transitions

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: SEATTLE

ORG_NAME: ACCESS TO ADVANCED HEALTH INSTITUTE

ORG_STATE: WA

PI_NAMEs: FOX, CHRISTOPHER  (contact)

PROJECT_TERMS: Advanced Development;Animal Model;Clinical;Communicable Diseases;Contracts;Disease Outbreaks;efficacy evaluation;efficacy testing;Emerging Communicable Diseases;Entamoeba histolytica;Formulation;immunogenicity;Individual;manufacture;research clinical testing;response;Safety;stability testing;Toxicology;vaccine development;Vaccines

PROJECT_TITLE: Advanced Development and Clinical Evaluation of an Entamoeba Histolytica Vaccine


NIH_SPENDING_CATS: Burden of Illness;Cancer;Prevention;Social Determinants of Health

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

PI_NAMEs: DOHERTY, JENNIFER  (contact)

PROJECT_TERMS: Annual Reports;anti-cancer research;Cancer Control;Cancer Patient;cancer statistics;Data;Diagnosis;Disease;Geography;Incidence;Infrastructure;insight;Malignant Neoplasms;Monitor;National Cancer Institute;Patients;Population;Prevalence;SEER Program;Social Characteristics;Subgroup;Time;treatment pattern;trend

PROJECT_TITLE: SEER CORE INFRASTRUCTURE SUPPORT


ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PI_NAMEs: LIU, LIHUA  (contact)


ORG_CITY: OAKLAND

ORG_NAME: PUBLIC HEALTH INSTITUTE

PI_NAMEs: CRESS, ROSEMARY  (contact)


PI_NAMEs: LIN-GOMEZ, SCARLETT  (contact)


ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PI_NAMEs: DURBIN, ERIC  (contact)


ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

PHR: The rotator cuff (RC) of the shoulder is a common source of pain and disability. Full-thickness RC tendon tears occur in >20% of the adult population and Veterans are particularly affected, due to the presence of injuries incurred during active duty and greater average age. Conventional magnetic resonance imaging (MRI) and ultrasound (US) can be used to assess tendon tear size, muscle atrophy, and fatty infiltration, but are less well- suited for evaluation of tendon degeneration and muscle fibrosis. Both of these important variables can increase surgical complexity and lead to lower patient outcome scores. We propose to develop, optimize, validate and translate novel quantitative MRI and US techniques for comprehensive assessment of RC collagen abnormalities and fibrosis. These techniques may guide treatment decisions, operative planning, and yield prognostic information. In addition, these techniques may be useful for many applications that are highly relevant to the VA population, such as muscle wasting due to aging, cachexia, chronic bed rest, and nervous system injury.

PI_NAMEs: CHANG, ERIC Y (contact)

PROJECT_TERMS: Acoustics;active duty;Adult;Affect;Age;Aging;Animal Model;arthropathies;attenuation;Award;Bed rest;Biological Markers;Biopsy Specimen;Cachexia;Cadaver;cartilage degradation;Chronic;Clinic;Clinical;cohort;Collagen;Couples;Data;density;Deterioration;Development;Diffusion;disability;elastography;Evaluation;experimental study;Fatty acid glycerol esters;Fibrosis;Frequencies;Functional disorder;Gender;Goals;Histologic;Histology;Human;human imaging;Image;imaging biomarker;imaging modality;Imaging Techniques;in vivo;Individual;Infiltration;Injury;Joint structure of shoulder region;Joints;kinematics;Least-Squares Analysis;Magic;Magnetic Resonance;Magnetic Resonance Imaging;Maps;Measurement;Measures;Methods;Modeling;Muscle;muscle degeneration;Muscular Atrophy;Myelin;Nerve;Nervous System Trauma;novel;Operative Surgical Procedures;Pain;Pathology;Patient-Focused Outcomes;Patients;Physiologic pulse;Population;prognostic;Property;Quantitative Evaluations;quantitative ultrasound;radio frequency;Rattus;Reference Standards;Relaxation;repaired;Reporting;Reproducibility;Resolution;Rotator Cuff;rotator cuff tear;Shapes;Shoulder;Skeletal Muscle;Source;Specimen;statistics;Structure;success;Techniques;Tendinopathy;Tendon structure;Thick;Time;Tissues;Translating;Translations;Ultrasonography;ultrasound;Veterans;virtual;Water

PROJECT_TITLE: Quantitative Magnetic Resonance and Ultrasound Imaging of Human Rotator Cuff Muscle and Tendon


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Estrogen;Mental Health;Neurosciences;Women's Health Research

ORG_CITY: PISCATAWAY

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative Chronic exposure to stressful experiences can result in maladaptive affective states yielding behavioral disturbances in rodents and stress-related mood disorders in humans. One potential cause is corticotropin- releasing hormone (CRH) signaling in bed nucleus of the stria terminalis (BNST), which is a sexually dimorphic integrative center for limbic information and valence monitoring. CRH-expressing BNST neurons (in the oval subnucleus) are critical mediators of the chronic stress response and may underlie sex differences therein. Our proposed studies will examine the role of BNST CRH signaling as a nexus for chronic stress-induced behavioral outcomes increasing our understanding of the impact of chronic stressors on affective states in both sexes.

PI_NAMEs: ROEPKE, TROY ADAM (contact);SAMUELS, BENJAMIN A

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Address;Affect;Affective;Amygdaloid structure;Anxiety;Area;Aromatase;Arousal;Behavior;Behavior Disorders;Behavioral;behavioral outcome;biological adaptation to stress;Brain region;Cell Nucleus;cell type;Cells;Chronic;Chronic Disease;Chronic stress;Cognition;Collaborations;Corticotropin-Releasing Hormone;Corticotropin-Releasing Hormone Receptors;Coupled;CRF receptor type 1;Data;Electrophysiology (science);Estrogen Receptors;Estrogens;Exposure to;Female;Genetic;Genomics;Hippocampus;hormonal signals;Human;Hypothalamic structure;Immunohistochemistry;Knockout Mice;locus ceruleus structure;male;Mediating;Mediator;Membrane Potentials;Molecular;Monitor;Mood Disorders;mouse model;Mus;Negative Valence;neural circuit;neuronal excitability;Neurons;neurophysiology;novel;optogenetics;Output;Pathway interactions;physiologic stressor;Population;Positive Valence;Predisposition;prevent;Property;psychological stressor;receptor binding;Receptor Signaling;Rest;Rodent;Role;sex;Sex Differences;sexual dimorphism;Signal Transduction;social;social defeat;social stressor;Steroids;Stress;stress disorder;stress resilience;Stressful Event;stressor;Structure;Structure of terminal stria nuclei of preoptic region;Techniques;transcriptome;Transgenic Mice;Transgenic Organisms;Translating;Variant;Viral

PROJECT_TITLE: Sex differences in CRH signaling in the ovBNST underlie effects of chronic stressors

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Nutrition;Pancreatic Cancer;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE  Most pancreatic ductal adenocarcinomas have a dense, fibrotic, and hypo-vascular stroma, rendering them hypoxic, nutrient deprived, and chemoresistant. The overall goal of this project is to gain a better understanding of the stromal components – vasculature and cancer associated fibroblasts – by which pancreatic cancer cells acquire essential nutrients. The information gained from these studies will provide guidance for precision medicine-based approaches targeting these essential metabolic “supply lines” in pancreas cancer.

PI_NAMEs: SIMON, M. CELESTE;STANGER, BEN Z (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: Actins;Address;Amino Acids;Anabolism;Angiogenesis Inhibitors;Biogenesis;Biological Assay;Biomass;Blood Vessels;cancer cell;Cancer cell line;Cell division;Cell Line;Cell model;Cell Proliferation;Cells;Centrifugation;Chemoresistance;Chemotaxis;Clinical Trials;clinically relevant;cohort;CRISPR/Cas technology;CXCL1 gene;cytokine;Data;Data Set;Development;Dominant-Negative Mutation;Ecosystem;Enzyme-Linked Immunosorbent Assay;experimental study;Exposure to;fatty acid biosynthesis;Fibroblasts;Flow Cytometry;FRAP1 gene;Gene Expression;Genetically Engineered Mouse;Genome;Geography;Goals;Heterogeneity;Hour;Human;human data;human tissue;Hypervascular;Hypoxia;Image Cytometry;imaging platform;Immunoblot Analysis;immunocytochemistry;Implant;inhibitor;innovation;Intake;Intercellular Fluid;Interleukin-8;Intervention;Iron;Iron Chelation;Label;lipid metabolism;Lipid Peroxidation;Lipids;live cell imaging;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Mediating;Metabolic;metabolomics;migration;Modeling;Molecular;Monitor;mouse model;Neighborhoods;neoplastic cell;neutrophil;Neutrophil Infiltration;normoxia;Nutrient;nutrient deprivation;Oxygen;Palmitates;Pancreas;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Pathway interactions;Peripheral;peripheral blood;Peripheral Blood Mononuclear Cell;pharmacologic;Physiological;Polyunsaturated Fatty Acids;precision medicine;Process;programs;Proliferating;Protein Biosynthesis;Proteins;reconstitution;regional difference;response;Sampling;Shapes;single-cell RNA sequencing;small molecule;Source;Stearoyl-CoA Desaturase;sugar;supply chain;Techniques;Testing;Therapeutic;Time;tissue resource;transcriptome sequencing;trend;Triglycerides;tumor;tumor heterogeneity;tumor microenvironment;Unsaturated Fatty Acids;Western Blotting

PROJECT_TITLE: Stromal and vascular inputs into pancreatic cancer tumor neighborhoods

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]