NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases

PI_NAMEs: LOUIS, JOHN  (contact)

PROJECT_TERMS: 2019-nCoV;Active Sites;Adopted;Affinity;Anti-viral Agents;antiviral drug development;Appearance;Binding;Biochemical;biophysical techniques;C-terminal;Caspase;Chymase;Complex;COVID-19 treatment;Dengue Virus;dimer;Dimerization;Dissociation;Drug resistance;Engineering;Enzymes;Equilibrium;Escherichia coli;improved;In Vitro;inhibitor;insight;Investigation;Kinetics;Length;Mediating;method development;Methods;mimetics;Modeling;Molecular;Molecular Conformation;Monitor;monomer;mutant;Mutation;N-terminal;nirmatrelvir;Norovirus;Pathway interactions;Paxlovid;Peptide Hydrolases;Polyproteins;Population;Process;Protease Inhibitor;Protein Dynamics;Rapid screening;Reaction;Recombinants;Reporting;resistance mutation;Sampling;SARS coronavirus;SARS-CoV-2 protease;single molecule;Site;Spectrum Analysis;Structure;Temperature;Thermodynamics;three dimensional structure;Time;Variant;Viral;Virus;Visualization;X-Ray Crystallography

PROJECT_TITLE: Biochemical and Structural Studies of Viral Proteases


ACTIVITY: ZIA

ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Neurosciences;Nutrition;Obesity

PI_NAMEs: LUTAS, ANDREW  (contact)

PROJECT_TERMS: Animal Behavior;Animals;Area;awake;Axon;Behavior;behavioral response;Biochemical;Biochemistry;Biosensor;Body Weight;Brain;Brain region;Brain Stem;Complex;Cyclic AMP;Desire for food;Diabetes Mellitus;Dopamine;Eating;Fluorescence;Fluorescence Microscopy;Food;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;GCG gene;Genetic;Goals;Hour;Hypothalamic structure;imaging approach;Implant;in vivo;in vivo fluorescence imaging;lens;Ligands;Measures;Modeling;Molecular;Monitor;Motivation;Mus;neural circuit;Neuromodulator;Neurons;neuroregulation;neurotransmitter release;novel therapeutic intervention;novel therapeutics;obesity treatment;Opioid;Optics;parabrachial nucleus;pharmacologic;Physiological;Population;presynaptic;Presynaptic Terminals;Process;receptor;Receptor Activation;Reporting;Resolution;Role;Signal Transduction;Signaling Molecule;Site;Slice;Stimulus;Synaptic Vesicles;Time;two photon microscopy;vesicular release;Visualization

PROJECT_TITLE: Compartmentalized molecular signaling in neural circuits controlling appetite


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity

ORG_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

PROJECT_TERMS: Address;adult obesity;Affect;American;Amygdaloid structure;Animals;Area;awake;Behavior;Behavioral Assay;Biochemical;Biosensor;Brain;Calories;Cues;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Decision Making;Diabetes Mellitus;Dopamine;Dorsal;Eating;Enkephalins;Equipment;feeding;Feeding behaviors;Fluorescence;Food;food craving;food marketing;G-Protein-Coupled Receptors;Genetic;Glutamates;Goals;Heart Diseases;Hormones;Human;Image;inhibitor;Learning;Microscope;model organism;Molecular;Monitor;motivated behavior;Motivation;Mus;neural;neural circuit;Neuromodulator;Neurons;Neuropeptides;neuroregulation;Obesity;Obesity Epidemic;Operant Conditioning;optogenetics;parabrachial nucleus;Pharmacological Treatment;Physiological;Play;postsynaptic;Presynaptic Terminals;Reporting;Resolution;response;Risk;Role;Sensory;Serotonin;Signal Pathway;Signal Transduction;social;Stimulus;synergism;System;Therapeutic;transcription factor;two-photon;Ventral Tegmental Area

PROJECT_TITLE: Neuromodulator signals regulating cue-induced feeding


PROJECT_TERMS: addiction;Address;Adenylate Cyclase;Animal Model;Area;awake;Behavior;Biosensor;Brain Stem;cell type;Central Nervous System;Chronic;comorbidity;Consumption;craving;Desire for food;Diet;Dopamine Receptor;Eating;effective therapy;Energy consumption;Equipment;Fasting;feeding;Fluorescence;Fluorescence Microscopy;Food;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;GCG gene;Goals;hedonic;Hunger;Hypothalamic structure;improved;in vivo fluorescence;Ligands;Measurement;Measures;melanocortin receptor;Methods;Microscopy;Molecular;Monitor;Motivation;Mus;neural circuit;Neurons;Obesity;obesity treatment;optical imaging;pharmacologic;phosphoric diester hydrolase;Photometry;Population;receptor;Receptor Activation;Receptor Signaling;Resolution;Rodent Model;Safety;Satiation;Signal Transduction;Transgenic Mice;Treatment Efficacy;two photon microscopy;Viral Genes;Visualization;Work

PROJECT_TITLE: Investigating appetite control by G protein-coupled receptors


PI_NAMEs: MIROSHNIKOVA, YEKATERINA  (contact)

PROJECT_TERMS: 3-Dimensional;Aggressive behavior;Aging;Aneuploidy;Architecture;Area;Attenuated;Behavior;Biochemical;biological adaptation to stress;Biological Models;Cancer Patient;cell fate specification;Cell Maintenance;Cell Nucleus;Cells;Cellular biology;Chromatin;clinically relevant;Colorectal Cancer;Complex;Cytoskeleton;Disease;Elements;emerin;Environment;Exhibits;experimental study;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic Transcription;Genome;Health;Heterochromatin;high throughput screening;Homeostasis;Human Genome;Immune;Immunofluorescence Immunologic;immunopathology;Impairment;In Vitro;interest;Intrinsic factor;Link;Malignant Neoplasms;Mammalian Cell;mechanical drive;mechanical force;Mechanical Stress;Mechanics;mechanotransduction;Mediating;Metabolic;Morphology;morphometry;Nature;Neoplasm Metastasis;Nuclear;Nuclear Envelope;Nuclear Lamina;Nuclear Pore;Organoids;Outcome;Paper;Pathway interactions;Patients;Peripheral;Process;prognostic;Proteins;Proteomics;Publications;quantitative imaging;Repression;Research;Risk;Role;Shapes;Signal Transduction;stem cell fate specification;Stereotyping;superresolution imaging;System;Tissues;TP53 gene;transcriptome;Work;Writing

PROJECT_TITLE: Nuclear and chromatin mechanics in cell fate specification


NIH_SPENDING_CATS: Bioengineering;Biotechnology

PI_NAMEs: WANG, QUAN  (contact)

PROJECT_TERMS: Adopted;Area;Base Pairing;Binding;Biochemical;Biological;Biological Assay;Complement;CRISPR/Cas technology;design;Detection;detector;Disease;DNA;Dyes;Exhibits;Experimental Designs;experimental study;Fluorescence;Fluorescence Resonance Energy Transfer;follow-up;frontier;gene editing technology;Goals;Guide RNA;Heterogeneity;Holoenzymes;Immobilization;Individual;insight;instrument;instrumentation;Investigation;Kinetics;Learning;Measurement;Methamphetamine;Methods;millisecond;Modality;Molecular;Molecular Conformation;Molecular Probes;Molecular Structure;Nature;new technology;Noise;novel;Pathway interactions;Performance;Photons;Publishing;Reaction;Resolution;Ribonucleoproteins;RNA;RNA Conformation;single molecule;single-molecule FRET;Site;Source;Specificity;Spectrum Analysis;structural biology;Structure;Surface;System;Time;tool;ultra high resolution;Uncertainty

PROJECT_TITLE: Probing single-molecule structure and dynamics with an anti-Brownian trap


PI_NAMEs: FRAKES, ASHLEY  (contact)

PROJECT_TERMS: Age of Onset;age related;Aging;Animals;Astrocytes;Awareness;Behavioral Assay;Biological Models;Brain;brain health;Caenorhabditis elegans;Cells;Cellular Stress;Central Nervous System;Communication;Disease;endoplasmic reticulum stress;extend lifespan;first responder;functional genomics;Genetic;Goals;Homeostasis;Longevity;Metabolic Diseases;Microscopy;misfolded protein;Mus;Neurodegenerative Disorders;Neuroglia;Neurologist;Nutrient;Patients;Peripheral;Play;prevent;protein aggregation;Proteins;Publishing;Regulation;Resistance;response;Role;Signal Transduction;Signaling Molecule;stem;Stress;stressor;therapeutic biomarker;therapeutic target;Tissues;tool;transcription factor;Transcriptional Activation;Viral;Work;XBP1 gene

PROJECT_TITLE: Glial regulation of ER stress resistance


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Obesity;Prevention

PI_NAMEs: SIMONDS, WILLIAM F (contact)

PROJECT_TERMS: Acceleration;Affect;Alzheimer's Disease;analytical method;Behavioral;Disease;disorder risk;Disparity;Etiology;Gender;gene discovery;Genes;Genetic;genetic analysis;genetic variant;Genetic Variation;Genome;genome-wide;Genomics;high risk;Hypertension;indexing;Intercistronic Region;Introns;Investigation;Maps;Missense Mutation;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Risk;risk variant;RNA Splicing;Single Nucleotide Polymorphism;Site;Variant

PROJECT_TITLE: Analysis of polygenic disease risk and etiology by indexing ancestry- and gender-specific gene variants predicted to impact function


NIH_SPENDING_CATS: Genetics

PI_NAMEs: RODGERS, MARGARET  (contact)

PROJECT_TERMS: 5' Splice Site;Address;Area;Base Pairing;Binding Proteins;Biological;Biology;Collaborations;Coupling;Disease;Genetic;Genetic Transcription;Goals;Guide RNA;In Vitro;in vivo;in vivo imaging;interest;Kinetics;Laboratories;Messenger RNA;Microscopy;Modification;Molecular;Molecular Biology;National Institute of Child Health and Human Development;Nucleotides;Pathway interactions;Process;Protein Biochemistry;Proteins;reconstitution;Regulation;Reporter;Research;Resolution;Ribonucleoproteins;Ribosomal RNA;Ribosomes;RNA;RNA Biochemistry;RNA Folding;RNA Processing;RNA Splicing;single molecule;Site;Small Nucleolar Ribonucleoproteins;Small RNA;Spliceosome Assembly Pathway;Spliceosomes;Structure;System;Time;tool;Transcription Elongation;U1 Small Nuclear Ribonucleoprotein;United States National Institutes of Health;Work;yeast genetics

PROJECT_TITLE: Molecular mechanisms for co-transcriptional assembly of ribonucleoproteins


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Cancer;Liver Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Rare Diseases

PI_NAMEs: HSU, CHRISTINE  (contact)

PROJECT_TERMS: Abdomen;Academic Medical Centers;American;Artificial Intelligence;artificial intelligence model;Biological Markers;cancer risk;Carcinoma;Cirrhosis;Clinical;Clinical Data;clinical predictors;cohort;Collaborations;Data;Data Set;Demographic Factors;Development;Fibrosis;Image;image processing;Institutional Review Boards;Laboratories;Liver diseases;Magnetic Resonance Imaging;Malignant neoplasm of liver;model building;Modeling;Outcome;Patients;Primary carcinoma of the liver cells;Protocols documentation;radiological imaging;Radiology Specialty;Recommendation;recruit;Retrospective Studies;Risk;screening;Screening for Hepatocellular Cancer;ultrasound;United States National Institutes of Health

PROJECT_TITLE: Retrospective Study to Develop a Model Using Artificial Intelligence to Predict Hepatocellular Carcinoma Risk in Cirrhosis


NIH_SPENDING_CATS: Clinical Research;Kidney Disease;Rare Diseases

PI_NAMEs: WALDMAN, MERYL  (contact)

PROJECT_TITLE: Studies of Immunologically-Mediated Kidney Diseases


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease;Rare Diseases

PROJECT_TERMS: arm;B-Lymphocytes;belimumab;Benefits and Risks;Cells;Cyclosporine;Disease remission;Dose;Effectiveness;effectiveness evaluation;Enrollment;Idiopathic Membranous Nephropathy;Intravenous;Intravenous infusion procedures;Membranous Glomerulonephritis;Multicenter Trials;Nephrotic Syndrome;Partial Remission;Participant;Pharmaceutical Preparations;Pilot Projects;Placebos;primary endpoint;Proteinuria;Randomized;Regimen;response;rituximab;Safety;Schedule;Serum Albumin;subcutaneous;Testing;treatment duration;treatment trial

PROJECT_TITLE: Treatment trials- Rituximab plus cyclosporine for  MN and Belimumab plus rituximab for MN  (REBOOT)


PROJECT_TITLE: Towards cryogenic single-molecule FRET spectroscopy as a structural biology tool


PI_NAMEs: CHELOHA, ROSS  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affinity;Anti-viral Agents;anti-viral efficacy;Antibodies;Binding;Biological;CCR5 gene;CD4 Positive T Lymphocytes;Cell surface;cell type;chemical synthesis;clinical application;Collection;CXCR4 gene;Development;Dose;Generations;Goals;HIV;HIV Envelope Protein gp120;HIV Infections;improved;Individual;Infection prevention;inhibitor;Length;Link;Mammalian Cell;Medical;Membrane;Methods;Monoclonal Antibodies;mutant;nanobodies;novel;novel strategies;Pathogenicity;Peptides;Pharmaceutical Preparations;polypeptide;Predisposition;Proteins;receptor;Recombinants;Regimen;Reporting;Research;resistance mechanism;Role;Scheme;side effect;Site;Specificity;synthetic peptide;Therapeutic;therapeutic target;tool;Toxic effect;transmission process;Viral;Viral Drug Resistance;Viral Physiology;Viral Proteins;viral resistance;Virus;Virus Diseases;virus infection mechanism;Virus Inhibitors

PROJECT_TITLE: Development of new antibody-fusion inhibitor conjugates to block HIV infection


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Atherosclerosis;Biodefense and Related Countermeasures;Cardiovascular;Coronaviruses;Emerging Infectious Diseases;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Infectious Diseases;Kidney Disease

PI_NAMEs: ZELDIN, DARRYL C (contact)

PROJECT_TERMS: 2019-nCoV;Acids;Action Potentials;Affect;Alteplase;Anabolism;Anatomy;angiogenesis;animal model selection;Antiinflammatory Effect;Apoptosis;arachidonate;Arachidonic Acids;Area;Atherosclerosis;attenuation;beta-adrenergic receptor;Biochemical;Blood Vessels;Cardiac;Cardiac Electrophysiologic Techniques;Cardiac Myocytes;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular Physiology;Cardiovascular system;Cell Adhesion Molecules;cohort;COVID-19;CYP2C19 gene;CYP2J2 gene;CYP2J5 gene;Cytochrome P450;cytokine;cytokine release syndrome;eicosanoid metabolism;Eicosanoids;Endothelial Cells;Endothelium;Enzymes;Epoxide hydrolase;Evaluation;Exhibits;Gene Expression;Genes;Genetic Polymorphism;Glycols;Goals;Growth;Heart;heart function;Human;human coronavirus;human disease;human model;Hydrolase;Hydrolysis;Hypertension;Hypoxia;improved;in vivo;inhibitor;Injury;Ischemia;ischemic injury;Kidney;Kidney Diseases;Knockout Mice;Left Ventricular Function;Malignant Neoplasms;Microsomal Epoxide Hydrolase;Molecular;multi-ethnic;Mus;Myocardial Ischemia;Myosin Heavy Chains;Nitric Oxide;novel coronavirus;Pathway interactions;Physiology;promoter;Recovery;Recovery of Function;Renal function;Research;Retina;Role;SARS coronavirus;Severe Acute Respiratory Syndrome;Sodium-Restricted Diet;Tennessee;Transgenic Mice;Tumor Promotion;Variant;vascular smooth muscle cell migration;Vascularization;Vasodilator Agents;Ventricular Cardiac alpha-Myosin;Work

PROJECT_TITLE: Characterization And Functional Significance Of P450 Arachidonate Epoxygenases


NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Clinical Research;Food Allergies;Health Effects of Indoor Air Pollution;Health Services;Lung;Social Determinants of Health

ORG_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

PROJECT_TERMS: Adherence;Adoption;Age;Agreement;allergen Bla g 1;Allergens;Allergic;Allergic Disease;Area;Asthma;asthma exacerbation;asthmatic patient;Attitude;care systems;Characteristics;cockroach allergen;Collaborations;comorbidity;Complex;cooking;Data;design;Development;Disease;Dust;Endotoxins;Environment;Environmental Exposure;environmental intervention;Environmental Risk Factor;environmental tobacco smoke;Exposure to;food allergen;Goals;Guidelines;Health;Home;Housing;Human;Hypersensitivity;IgE;Immunologics;implementation strategy;improved;indoor air;indoor allergen;insight;Investigation;Irritants;Knowledge;large datasets;Lead;Measures;Mediating;Medical;Modeling;Monitor;Morbidity - disease rate;mortality;National Ambulatory Medical Care Survey;National Health and Nutrition Examination Survey;Neighborhood Health Center;Participant;Patient Care;Patient Self-Report;Patients;Pattern;Prevalence;Primary Care;programs;Provider;Questionnaires;Recommendation;Research;Research Personnel;Respiratory Disease;Role;Schools;Self Efficacy;Serum;skills;Source;Specialist;Surveys;Testing;Time;trend;U.S. Department of Housing and Urban Development;United States National Center for Health Statistics;uptake;Work

PROJECT_TITLE: Indoor Allergens And Asthma


NIH_SPENDING_CATS: Asthma;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza

PROJECT_TERMS: Acute;adaptive immune response;airway hyperresponsiveness;Allergens;Allergic;allergic airway inflammation;Alveolar Cell;Alveolar Macrophages;alveolar type II cell;Anabolism;Appearance;Attenuated;Biochemical;Bleomycin;Body Temperature Changes;Body Weight;Breeding;Bronchoalveolar Lavage Fluid;Bronchoconstriction;CCL17 gene;Cell Adhesion Molecules;Cell Count;Cells;chemokine;Clara cell;cyclooxygenase 1;cyclooxygenase 2;cysteinyl-leukotriene;Cytochrome-c Oxidase Deficiency;cytokine;Data;Defect;Dinoprostone;Distal;Endotoxins;Environment;environmental agent;eosinophil;Eotaxin;Equilibrium;Exhibits;Genes;Genotype;Goals;Histopathology;Host resistance;Human;Hydroxyproline;IgE;immune function;Immune response;In Vitro;in vivo;indexing;Infection;Inflammation;Inflammatory;Inflammatory Response;Inflammatory Response Pathway;Influenza;influenza infection;influenzavirus;Inhalation;Intercellular adhesion molecule 1;Interleukin-13;Interleukin-4;Interleukin-5;Knock-out;Knockout Mice;Leukotriene B4;Leukotrienes;Lipopolysaccharides;Liquid substance;Lung;Lung Compliance;Lymphocyte;Mechanics;methacholine;Modeling;Morphology;mortality;MUC5AC gene;Mus;Ovalbumin;overexpression;Pharmaceutical Preparations;Physiological;promoter;Prostaglandin Production;Prostaglandin-Endoperoxide Synthase;Prostaglandins;PTGS2 gene;Pulmonary Fibrosis;pulmonary function;Pulmonary Inflammation;respiratory;response;Role;Stimulus;T-Lymphocyte;Transgenes;Transgenic Mice;Trichrome stain;Type II Epithelial Receptor Cell;Up-Regulation;vanadium pentoxide;Vascular Cell Adhesion Molecule-1;Viral;Virus Diseases;Wild Type Mouse

PROJECT_TITLE: Alterations In Pulmonary Immune Function And Host Resistance In COX Null Mice


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Data Science;Eye Disease and Disorders of Vision;Lung;Machine Learning and Artificial Intelligence;Macular Degeneration;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_NAME: NATIONAL LIBRARY OF MEDICINE

PI_NAMEs: LU, ZHIYONG  (contact)

PROJECT_TERMS: Advanced Development;age related;Age related macular degeneration;Algorithms;American;Anterior;Appearance;Area;Area Under Curve;Benign;Blindness;Blood Vessels;Body Regions;Cataract;Categories;Characteristics;Classification;Clinic;Clinical;Clinical Data;clinical decision support;clinical decision-making;clinical imaging;clinical investigation;Clinical Research;Clinical Trials;Color;Communities;Computer software;Computerized Medical Record;Confidence Intervals;Data;Data Set;deep learning;deep learning algorithm;Detection;Diagnosis;Disease;disease diagnosis;disease prognosis;Epidemiology;Evaluation;Eye diseases;Fundus;Fundus photography;Human;Image Analysis;improved;Individual;insight;Label;large-scale imaging data;lymph nodes;lymphadenopathy;Machine Learning;machine learning algorithm;Magnetic Resonance Imaging;Malignant - descriptor;Medical Imaging;Methods;Mining;Modernization;MRI Scans;multimodality;Natural Language Processing;Neoplasm Metastasis;neural network;novel;Nuclear;Ophthalmologist;Ophthalmology;Participant;Patient Care;patient population;Patients;Pelvis;Performance;Persons;Play;Population;Process;Prognosis;prognostic;radiologist;Radiology Specialty;Reading;Rectum;Regional Anatomy;Reporting;Research;Retina;retinal imaging;Risk;Role;screening;Severities;Singapore;Specialist;Staging;success;System;Techniques;Testing;Text;Thoracic Radiography;Training;United States National Institutes of Health;Update;Visualization;Work;X-Ray Computed Tomography;X-Ray Medical Imaging

PROJECT_TITLE: Machine learning for medical imaging: automated disease diagnosis and prognosis


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biomedical Imaging;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Rare Diseases;Tuberculosis

PI_NAMEs: JAEGER, STEFAN  (contact)

PROJECT_TERMS: 15 year old;Acquired Immunodeficiency Syndrome;Africa;Aftercare;Agreement;antiretroviral therapy;Asia;Bacteriology;Cardiac;Caribbean region;Central America;Clinic;Clinical;clinical center;Clinical Data;clinical diagnosis;Clinical Research;co-infection;cohort;Communities;comorbidity;Country;Data;data portal;Data Set;Database Management Systems;Databases;Diagnosis;Disease;Disease Management;Drug resistance;Drug resistance in tuberculosis;drug-sensitive;Epidemic;Epidemiology;Etiology;experimental study;Funding;Future;genomic data;Geographic Locations;Geography;Guidelines;Health;Hepatitis;HIV;HIV Seronegativity;HIV Seropositivity;HIV/AIDS;HIV/TB;Impairment;Individual;insight;interest;International;Laboratories;Language;Lung;Machine Learning;machine learning classifier;machine learning method;Malawi;Malignant Neoplasms;member;Mental Health;Modeling;Mozambique;multidisciplinary;National Institute of Allergy and Infectious Disease;neglect;NIH Office of AIDS Research;North America;Outcome;Paper;Participant;Patient-Focused Outcomes;Patients;Persons;Phenotype;Pilot Projects;Prediction of Response to Therapy;predictive modeling;Preventive Medicine;programs;prospective;Pulmonary Tuberculosis;Quality of life;Radiologic Finding;radiological imaging;Records;Research;Research Personnel;Research Priority;Research Project Grants;Resources;Risk;Sample Size;Sampling;Series;Severities;Site;Social Medicine;socioeconomics;South Africa;South America;Southern Africa;standard of care;Substance Use Disorder;Switzerland;System;Thoracic Radiography;Training;training data;treatment and outcome;Treatment outcome;Tuberculosis;tuberculosis treatment;United States National Institutes of Health;United States National Library of Medicine;Universities;Update;working group;X-Ray Computed Tomography;X-Ray Medical Imaging;Zambia;Zimbabwe

PROJECT_TITLE: Enhancing the International Epidemiology Databases to Evaluate AIDS (IeDEA): A Pilot Study in Utilizing Machine Learning to Predict Treatment, Outcomes, and Phenotypes for HIV Patients Living with TB


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: OVCHARENKO, IVAN  (contact)

PROJECT_TERMS: Address;Animal Model;Binding Sites;cardiogenesis;Cardiovascular Diseases;Cause of Death;cell type;Code;Cognitive;Collaborations;comparative;comparative genomics;Complement;Computational algorithm;Computational Biology;computerized tools;Computing Methodologies;Development;Diagnostic;diagnostic development;Disease susceptibility;DNA Sequence;DNA Sequence Rearrangement;drug development;drug discovery;Elements;encryption;Enhancers;Evolution;Extramural Activities;follow-up;Gene Expression;Gene Expression Regulation;Gene Rearrangement;gene repression;Genes;Genetic Diseases;Genetic Enhancer Element;Genetic Transcription;Genome;Goals;Heart;Heart Diseases;Human;Human Genome;in vivo;in vivo evaluation;laboratory experiment;Machine Learning;Maps;model organism;Motivation;Mus;Mutation;novel;Organ;Pathway interactions;Phenotype;Play;Population;Proteins;Rana;Recording of previous events;Regulation;Regulatory Element;Regulatory Pathway;Research;Role;Sequence Analysis;Shapes;Site;Specificity;statistics;Techniques;therapeutic development;Tissues;transcription factor;transgene expression;United States;Untranslated RNA;Validation;Variant;whole genome;Zebrafish

PROJECT_TITLE: Regulatory landscape of the human genome: comparative and evolutionary analysis.


NIH_SPENDING_CATS: Bioengineering;Cancer;Data Science;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: PRZYTYCKA, TERESA  (contact)

PROJECT_TERMS: Address;advanced system;Algorithmic Software;Algorithms;Awareness;Binding;Biological;biological systems;cancer biomarkers;cancer type;Cell Adhesion;Cell Physiology;Cell Proliferation;Cells;Collaborations;Complex;Computational algorithm;Computational Biology;Computer Models;Computing Methodologies;Data;data integration;Dependence;Development;diagnostic biomarker;Disease;DNA;Drosophila genus;Elements;Environment;Epithelium;Evolution;explainable machine learning;Exposure to;fly;Future;G Protein-Coupled Receptor Signaling;Gene Dosage;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene function;Genes;Genetic;Genotype;Germ Cells;Germ Lines;Goals;gonad development;Gonadal structure;Graph;graph theory;Growth Factor;Health;heterogenous data;Immune;Immune response;innovation;insight;intercellular communication;interest;Investigation;Karyotype;Language;large datasets;large scale data;Machine Learning;machine learning model;Malignant Neoplasms;Melanoma;Mesenchymal;Methods;Modeling;Molecular;Mus;Mutation;National Institute of Diabetes and Digestive and Kidney Diseases;non-genetic;Normal tissue morphology;Pathway interactions;Phenotype;Play;Population;predictive marker;Process;Prognostic Marker;Property;Regulation;Regulatory Element;Reporting;Research;Resources;response;RNA;Role;Sampling;sex;Sex Chromosomes;sex determination;sexual dimorphism;Signal Transduction;Somatic Cell;Structure;System;Systems Biology;Techniques;Technology;The Cancer Genome Atlas;theories;Tissues;tool;tumor;tumor initiation;tumor microenvironment;tumor progression;Tumor Promotion

PROJECT_TITLE: Algorithmic approaches to systems biology, data integration, and evolution


PI_NAMEs: JIANG, XIAOFANG  (contact)

PROJECT_TERMS: Anatomy;Animals;Bacteria;Bacteriophages;Bilirubin;Binding Proteins;Cloud Computing;Collection;Communities;Comparative Genomic Analysis;Data;Databases;deep learning;Development;Diet;Enzymes;Evolution;Family;Firmicutes;Funding;Future;gastrointestinal;Gene Cluster;Genes;Genetic;genomic data;Genomics;Goals;gut microbiome;Health;Heme;Human;human disease;Human Microbiome;Icterus;Infant;Inflammatory Bowel Diseases;insight;interest;Manuscripts;Maryland;Metagenomics;microbial;Microbial Biofilms;microbial genome;microbial genomics;Microbiology;microbiome;model organism;Nature;novel;Outcome;Oxidoreductase;Patients;Phage Receptors;Phenotype;Prophages;Protein Family;Proteins;Publishing;receptor binding;Recording of previous events;Resources;Role;Shapes;Side;Specificity;therapy development;tool;trait;Translating;Universities;Vibrio;Viral Genome;Virulence Factors;Work

PROJECT_TITLE: Comparative genomic analysis of bacteria species


PI_NAMEs: PORTER, LAUREN  (contact)

PROJECT_TERMS: Adopted;Algorithms;Alzheimer's Disease;Amino Acid Sequence;Autoimmune;Bacterial Infections;Biochemistry;Biological;Biological Process;Cells;Communication;Disease;Functional disorder;Genome;Genomics;Goals;Health;Heterogeneity;Homologous Gene;Human;human disease;Life;Malignant Neoplasms;Methods;Molecular Conformation;Nature;news;Paper;protein aminoacid sequence;protein folding;protein structure;Proteins;Publications;Publishing;Research;Role;Structure;Testing;Textbooks;Training;Validation;Work;Writing

PROJECT_TITLE: Predictions and experimental validation of fold-switching proteins


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PROJECT_TITLE: Machine Learning and Natural Language Processing for Biomedical Applications


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Coronaviruses;Coronaviruses Therapeutics and Interventions;Data Science;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine

PI_NAMEs: LUNA, AUGUSTIN  (contact)

PROJECT_TERMS: 2019-nCoV;Address;Area;Basic Science;Biochemical;bioinformatics pipeline;Biological;biological standardization;Biology;cell behavior;Cell Line;Cells;Characteristics;clinical decision-making;Clinical Research;clinical subtypes;Clinical Trials;Communities;Complex;Computer Analysis;Computer Models;COVID-19;COVID-19 pandemic;Data;Data Reporting;Data Set;Development;Disease;DNA Sequence Alteration;drug repurposing;Drug Targeting;Elements;experimental study;Feedback;Gene Expression Regulation;Generations;Goals;Graph;graph database;Heterogeneity;human disease;improved;Institution;interoperability;Knowledge;Machine Learning;machine learning method;Malignant Neoplasms;Maps;Measurement;Measures;member;Metabolism;Methodology;Methods;molecular subtypes;Mutation;novel;Oncogenic;Pharmaceutical Preparations;Pharmacogenomics;Pharmacotherapy;Pre-Clinical Model;predictive marker;Property;Proteomics;rare cancer;Research;Research Personnel;response;Sarcoma;Scientist;Semantics;Signal Transduction;single cell analysis;Standardization;symposium;System;Systems Biology;Systems Development;Testing;tool;Translational Research;usability;Visual;Work

PROJECT_TITLE: Computational Analysis of Drug Response in Biological Networks


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Pediatric;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health;Telehealth;Tobacco;Tobacco Smoke and Health

PI_NAMEs: EL-TOUKHY, SHERINE  (contact)

PROJECT_TERMS: access disparities;adaptive intervention;Adolescent;adolescent health;Adult;Age;American Public Health Association;Awareness;Behavior;behavior change;Behavioral;Behavioral Medicine;Black Populations;Blood;Bluetooth;Body Temperature;Cellular Phone;Characteristics;Cigar;cigarette smoke;cigarette smoking;Cognitive;cohort;COVID-19 patient;COVID-19 test;Data;design;Devices;Diagnosis;digital;digital health;digital technology;Disease;Disease Surveillance;disparity reduction;Documentation;Ecological momentary assessment;Education;Effectiveness;efficacy evaluation;Electronic cigarette;Electronic Health Record;Eligibility Determination;Enrollment;Environment;Ethnic Origin;evidence base;experimental study;Female;Future;Goals;handheld mobile device;Health;Health behavior;Health Benefit;health data;Health Disparities Research;health disparity;health disparity populations;Health Information National Trends Survey;Health Personnel;Health Professional;Heart Rate;heart rate variability;human old age (65+);Improve Access;improved;Individual;insight;Internet;Intervention;Journals;Latino Population;Long COVID;Longitudinal, observational study;male;Manuscripts;Measures;meetings;member;Mental Health;mHealth;minority disparity;mobile computing;Monitor;never smoker;Nicotine;Operating System;Paper;Patient Outcomes Assessments;Patient Self-Report;Patients;Pattern;Peer Review;Persons;physical conditioning;Physiological;Population;Post-Acute Sequelae of SARS-CoV-2 Infection;precision medicine;Predisposition;Prevention Research;primary endpoint;Procedures;Protocols documentation;Provider;Publishing;Race;remote monitoring;Reporting;Research;respiratory;SARS-CoV-2 positive;screening;secondary endpoint;sex;Sleep;sleep onset;Sleep Stages;Smoking;smoking cessation;social media;Societies;sociodemographics;socioeconomic disadvantage;Subgroup;Surveys;Symptoms;System;Tablets;Technology;Telephone;Test Result;Time;Tobacco;tobacco prevention;tobacco products;Tobacco use;tobacco user;tool;trend;Update;uptake;wearable device;Youth

PROJECT_TITLE: Digital Health and Health Disparities Research Lab


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Depression;Electronic Nicotine Delivery Systems;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Tobacco

ORG_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

PI_NAMEs: WILLIAMS, FAUSTINE  (contact)

PROJECT_TERMS: Accounting;Adult;Affect;African American;aged;Alcohol consumption;alcohol measurement;Anxiety;Asian;Behavior;biopsychosocial factor;Black race;Cannabis;Cardiovascular system;Caring;Categories;Cessation of life;Characteristics;Chronic Disease;chronic pain;Clinical;Communication;COVID-19 pandemic;culturally appropriate intervention;Data;depression prevention;depressive symptoms;Electronic cigarette;electronic cigarette use;Emotional;Employment;Ethnic Origin;Ethnic Population;Exhibits;experience;food insecurity;food security;Generations;Health;health care delivery;Health Fairs;Health Insurance;Healthcare;High Prevalence;Hispanic Populations;Hypertension;Immigrant;Immigration;improved;Individual;Insurance Coverage;Intervention;Interview;Life;marijuana use;Mediation;Mental Depression;Mental disorders;Mental Health;mortality risk;multi-racial;Not Hispanic or Latino;Outcome;pandemic disease;Participant;Patient Self-Report;Pattern;Personal Satisfaction;Persons;Physical activity;Physical Function;Population;Prevalence;Probability;psychological distress;Psychosocial Factor;Race;racial population;Reporting;Research;Respondent;Risk;Sampling;satisfaction;screening;sex;Sleep Disorders;social;Social support;sociodemographics;Stress;structural determinants;substance use;Surveys;Symptoms;trend;Unemployment;Well in self

PROJECT_TITLE: Understanding Immigrants Stress-Related Mental Health to Promote and Improve Mental Wellbeing


NIH_SPENDING_CATS: American Indian or Alaska Native;Bioengineering;Biotechnology;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: MARIÑO-RAMÍREZ, LEONARDO  (contact)

PROJECT_TERMS: Admixture;African;Age;Algorithms;Area;biobank;Biomedical Research;case control;Catalogs;Code;cohort;Computer software;Country;Data;Data Set;Databases;deprivation;Diagnosis;directed attention;Disease;Disparate;Disparity;Electronic Health Record;Ethnic Population;European;European ancestry;Funding;Genes;Genetic;genetic analysis;genetic architecture;Genetic Programming;genetic variant;Genetic Variation;genome wide association study;genome-wide;genomic data;Genomics;Goals;Health;health determinants;health disparity;Health equity research;health inequalities;Healthcare;High Prevalence;Hispanic Americans;improved;Individual;interest;International Classification of Diseases;International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10);Internet;Latin America;Latin American;Least-Squares Analysis;Low Prevalence;Maps;Methods;Modernization;Native American community;Native Americans;Non-Insulin-Dependent Diabetes Mellitus;Participant;Pattern;Performance;personalized genomic medicine;Persons;Phenotype;Population;Population Group;Prevalence;Principal Component Analysis;programs;Public Health;repository;Research;Research Project Grants;residence;Running;Rye cereal;Sampling;Sampling Biases;sex;socioeconomics;Speed;Time;tool;Underrepresented Populations;Underserved Population;Variant;Visualization

PROJECT_TITLE: Genomics and Biobank Research for Health Equity


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Cancer;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Lung;Lung Cancer;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related

PI_NAMEs: FORDE, ALLANA  (contact)

PROJECT_TERMS: Address;Adult;African American;African American Women;African ancestry;Alaska Native;American Indians;Anxiety;Asian;Behavior;Biological;Black race;black women;cancer diagnosis;cardiovascular health;cardiovascular risk factor;Caucasians;Centers for Disease Control and Prevention (U.S.);Characteristics;Chi-Square Tests;Chronic;Code;cost;County;COVID-19;COVID-19 test;COVID-19 treatment;COVID-19 vaccination;COVID-19 vaccine;Data;Data Sources;Decision Making;depressive symptoms;Development;Discrimination;Education;Educational Status;Eligibility Determination;Equitable healthcare;ethnic difference;ethnic discrimination;ethnic disparity;ethnic health disparity;ethnic minority population;Ethnic Population;experience;Factor Analysis;Focus Groups;Fright;Future;future pandemic;Goals;Government;Health;Health Disparities Research;health disparity;Healthcare;Healthcare Systems;Heterogeneity;High Prevalence;high risk;Hispanic;Hypertension;indexing;Inequity;Insurance Coverage;Intervention;Interview;Laboratories;Language;Latina;Latino;Loneliness;lung cancer screening;Malignant neoplasm of lung;Malignant Neoplasms;maltreatment;Manuscripts;marginalization;Measures;Medical;models and simulation;Morbidity - disease rate;mortality;mortality disparity;multi-racial;Native Hawaiian or Other Pacific Islander;Nested Case-Control Study;Not Hispanic or Latino;Participant;perceived stress;Persons;preference;Prevalence;Preventive;Preventive service;programs;psychological distress;psychosocial;Psychosocial Factor;Qualitative Methods;Race;racial difference;racial discrimination;racial disparity;racial minority population;racial population;racism;Recommendation;Regression Analysis;Reporting;Research;response;Risk;Safety;Science;screening;side effect;simulation;Sister;Sleep disturbances;Spanish;stressor;Structural Racism;Structure;Surveys;Testing;Transportation;treatment services;trend;Trust;Vaccination;vaccine acceptance;White Women;willingness

PROJECT_TITLE: Race Related Stressors and Health Disparities Research Program


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Childhood Obesity;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Social Determinants of Health;Women's Health Research

PI_NAMEs: TAMURA, KOSUKE  (contact)

PROJECT_TERMS: access disparities;Address;Adolescent;Adult;African American Women;biobank;Biological Markers;boys;C-reactive protein;Cardiovascular Diseases;cardiovascular disorder risk;Caring;Characteristics;cohort;Cohort Studies;Collaborations;Communities;community violence;Cost Savings;County;Data;Data Set;density;depressive symptoms;deprivation;Diabetes Mellitus;Disease;Disparity;disparity elimination;disparity reduction;Extramural Activities;Female;Gender;girls;Goals;Health;health determinants;Health Professional;Hour;indexing;Inflammatory;Intervention;Investments;Jackson Heart Study;Laboratories;Link;Longitudinal Studies;male;Manuscripts;Mediating;Medical Care Costs;men;Mental Depression;Mental Health;Metabolic syndrome;middle age;mortality;Multi-Ethnic Study of Atherosclerosis;National Longitudinal Survey of Adolescent to Adult Health;neighborhood safety;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;Obesity;older adult;Outcome;Overweight;Participant;Physical activity;Physical environment;Population;Postbaccalaureate;Postdoctoral Fellow;Prevalence;productivity loss;Psychiatric Hospitals;Psychosocial Factor;Public Health;Publishing;Research;Research Personnel;Research Project Grants;residential segregation;Risk;Risk Factors;Role;Safety;Savings;sedentary lifestyle;segregation;Severities;Sleep;sleep health;social cohesion;Social Environment;Stress;structural determinants;Substance Use Disorder;Testing;Time;Weight;Woman;Work

PROJECT_TITLE: Socio-Spatial Determinants of Health (SSDH)


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Comparative Effectiveness Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: JAYASEKERA, JINANI  (contact)

PROJECT_TERMS: Address;Aerobic Exercise;Age;aged;Behavioral;Big Data;Biopsy;Breast;Breast Cancer Detection;Breast Cancer Prevention;Breast Cancer survivor;breast density;cancer care;Cancer Intervention and Surveillance Modeling Network;care delivery;Caring;Cessation of life;Characteristics;Clinical;clinical practice;Collaborations;Collection;comorbidity;Complex;Conduct Clinical Trials;Confidence Intervals;Data;Data Sources;Databases;Death Rate;Decision Aid;Decision Making;Development;Diagnosis;Dose;efficacy evaluation;Equity;ethnic disparity;Event;Exercise;Family;Future;Genomics;Guidelines;hazard;health equity;Health equity research;health goals;health literacy;Health Personnel;Health Services;High Risk Woman;human old age (65+);human very old age (85+);improved;Individual;instrument;International;Intervention;knowledge base;Laboratory Research;Life;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Mammography;Manuscripts;mathematical ability;mathematical model;Mathematical Model Simulation;Measurement;Measures;meetings;Meta-Analysis;Metastatic breast cancer;Modeling;models and simulation;mortality;network models;novel;Observational Study;older women;Online Systems;Outcome;Output;Participant;Patient-Focused Outcomes;Patients;Pattern;Peer Review;personalized decision;personalized health care;Policies;Process;programs;Publications;PubMed;racial disparity;Recommendation;Recording of previous events;Recreation;Recurrence;Reporting;Research;research study;response;Risk Factors;Science;screening;Second Primary Cancers;shared decision making;simulation;Structural Racism;Study models;Subgroup;survivorship;systematic review;Target Populations;Testing;tool;Uncertainty;uptake;usability;Validation;Variant;web based interface;Woman;Women's mortality;working group

PROJECT_TITLE: Health Equity and Decision Sciences


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Human Genome;Immunotherapy;Lymphatic Research;Lymphoma;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_NAME: DIVISION OF CLINICAL SCIENCES - NCI

PI_NAMEs: JAFFE, ELAINE  (contact)

PROJECT_TERMS: Address;Adipocytes;Adipose tissue;African American;Age;Alleles;American;Asian population;Autoimmune Diseases;Awareness;B-Cell Lymphomas;B-Cell Neoplasm;B-Lymphocytes;Biology;BRAF gene;Caucasians;Cell Differentiation process;Cell Proliferation;cell type;Cells;Childhood;Classification;Clinical;Clinical Management;clinical practice;Clonal Expansion;Clonality;Consensus;CSF1R gene;Cutaneous;Cytotoxic T-Lymphocytes;Dendritic Cells;Diagnosis;Diagnostic;diagnostic criteria;diagnostic tool;Disease;disease classification;East Asian;eosinophil;Eosinophilia;Eosinophilic Granuloma;Ethnic Origin;ETV3 gene;European;Exhibits;follow-up;Functional disorder;General Population;Genetic;genetic approach;Genomic approach;genomic profiles;Genomics;Genotype;Germ-Line Mutation;Goals;Heel;Hematologic Neoplasms;Hematopoietic Neoplasms;Hispanic;histiocyte;Histiocytosis;Histologic;Immune system;Immunohistochemistry;immunomodulatory therapies;Immunophenotyping;improved;Individual;Inferior;insight;International;Ki-1 Large-Cell Lymphoma;Knowledge;KRAS2 gene;langerin;Link;Literature;Lobular;Lymphocyte;lymphoid neoplasm;Lymphoma;Malignant Neoplasms;MAP2K1 gene;Modification;Molecular;Morphology;Mutation;Mutation Analysis;NCOA2 gene;Neoplasms;Nodal;Nomenclature;North America;novel diagnostics;Panniculitis;Pathogenesis;Pathologic;Patients;Phenotype;Plasma Cells;Polynesian;Process;Prognosis;Property;Publications;Recommendation;Reporting;Scientist;Series;Signal Pathway;South Asian;Stains;subcutaneous;Subcutaneous Nodule;Symptoms;T-Cell Lymphoma;T-Lymphocyte Gene Rearrangement;Terminology;Time;Tissues;transcriptome sequencing;Translating;treatment response;tumor;Update;Variant;Work

PROJECT_TITLE: Lymphoma Disease Discovery and Definition


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;HIV/AIDS;Human Genome;Immunization;Immunotherapy;Microbiome;Pediatric;Pediatric - AIDS;Prevention;Vaccine Related;Vaccine Related - AIDS;Women's Health Research

PI_NAMEs: BERZOFSKY, JAY A (contact)

PROJECT_TERMS: Adenoviruses;Adjuvant;Affect;Affinity;Age;Agonist;Allogenic;alpha-galactosylceramide;analog;anergy;anti-PD-1;anti-PD-L1;Antibodies;Antigen Presentation;Antigens;Arylsulfatases;Autologous;Avidity;Binding;Biotechnology;Breeding;Cancer Etiology;cancer immunotherapy;Cancer Vaccines;CCR;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;cell killing;Cells;Cholesterol;Clinic;Clinical;Clinical Trials;Combined Vaccines;Cooperative Research and Development Agreement;cytokine;Cytoprotection;Cytotoxic T-Lymphocytes;Data;Dose;Endometrial Carcinoma;Endosomes;Epitopes;Equilibrium;ERBB2 gene;Evaluable Disease;Excision;extracellular;Failure;FOXP3 gene;Gene Expression Profile;Glycolipids;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Growth;gut microbiome;Helper-Inducer T-Lymphocyte;Histocompatibility;HLA-A2 Antigen;Human;IL17 gene;Immune checkpoint inhibitor;Immune response;Immunity;Immunologic Surveillance;Immunology;immunoregulation;Immunotherapy;improved;inhibitor;Interleukin-12;Interleukin-13;Interleukin-15;invention;KDR gene;Knock-in Mouse;Knockout Mice;Ligands;Lipids;Lung;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Mammary Neoplasms;Mediating;Melanoma patient;Metastatic Neoplasm to the Lung;Microbe;microbiome;microbiome alteration;Modification;Mucosal Immunity;Mucous Membrane;Mus;Myeloid Cells;Myeloid-derived suppressor cells;Natural Immunity;Neoplasm Metastasis;neoplastic cell;novel;novel strategies;Omega-3 Fatty Acids;Pathway interactions;Patients;PD-1 blockade;PD-L1 blockade;Peptides;Phase I Clinical Trials;phase I trial;Phase I/II Trial;PPBP gene;preclinical study;prevent;Primary Neoplasm;Process;Publishing;Purinergic P1 Receptors;Rattus;receptor for advanced glycation endproducts;recruit;Regulation;Regulatory T-Lymphocyte;Research;response;Role;Safety;Sampling;scavenger receptor;single-cell RNA sequencing;Skin;Stimulant;Structure;Sulfoglycosphingolipids;synergism;T cell response;T-Cell Depletion;T-Lymphocyte;Testing;Therapeutic Effect;Time;Tissues;TLR3 gene;Toll-like receptors;Training;transcriptome sequencing;Transforming Growth Factor beta;Transgenic Mice;Translating;Translations;Transmembrane Domain;Trastuzumab;Tropism;tumor;Tumor Antigens;tumor growth;Tumor Immunity;Tumor Promotion;Vaccine Adjuvant;Vaccine Design;vaccine efficacy;vaccine immunogenicity;vaccine strategy;Vaccinee;Vaccines;Viral Cancer;viral transmission;Virus;Virus Diseases;Work

PROJECT_TITLE: Vaccine and immunotherapy strategies for cancer and viruses causing cancer


PI_NAMEs: MITCHELL, JAMES  (contact)

PROJECT_TERMS: Attention;Blood flow;cancer cell;cancer therapy;Cell Cycle;Cells;chemotherapy;Clinical Trials;contrast enhanced;Cytolysis;Data;Diameter;Dose;Electron Spin Resonance Spectroscopy;Exposure to;Functional Imaging;Gamma-H2AX;Goals;Heat-Shock Proteins 90;Hemoglobin;Human;Hypoxia;Image;improved;In Vitro;in vivo;inhibitor;interest;Ionizing radiation;KRAS2 gene;Lactate Dehydrogenase;lactate dehydrogenase A;Lymphocyte;Magnetic Resonance Imaging;Manuscripts;Measurement;Mediating;metabolic imaging;Metabolism;Mitochondria;Modification;Molecular;molecular imaging;Molecular Target;Mus;Mutation;neoplastic cell;Normal tissue morphology;novel;Oncology;Oxygen;Oxygen Consumption;Physiology;pre-clinical research;Process;programmed cell death protein 1;Publications;Publishing;Pyruvate;Radiation;radiation effect;Radiation induced damage;radiation response;Radiation Tolerance;Radiation-Protective Agents;Radiosensitization;Ras Inhibitor;Research;Research Design;Resistance;response;Rodent;senescence;senescent cell;T-Cell Activation;T-Lymphocyte;targeted agent;Therapeutic;tissue oxygenation;Tissues;Toxic effect;Translating;treatment response;tumor;tumor hypoxia;tumor microenvironment;Tumor Tissue;vasculogenesis

PROJECT_TITLE: Modulation of Therapeutic Response


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Networking and Information Technology R&D (NITRD);Radiation Oncology

PI_NAMEs: MILLER, ROBERT  (contact)

PROJECT_TITLE: Radiation Field Modeling and Computerized Treatment Planning


PROJECT_TERMS: Animals;Anti-Inflammatory Agents;Antioxidants;Bacteria;Bile Acids;Body Weight decreased;cancer therapy;carcinogenesis;catalase;cell injury;Cells;Chemicals;Chemoprevention;Consumption;Control Animal;Control Groups;Diet;Disease;Drug Targeting;Environment;fatty acid metabolism;feeding;Free Radicals;Gene Expression;Genes;germ free condition;glucagon-like peptide 1;Goals;gut microbiome;gut microbiota;High Fat Diet;Human;Immune;Ionizing radiation;Laboratories;Lead;Mediating;Metabolism;Modeling;Molecular;Mus;Nerve Degeneration;Obesity;Outcome;Oxidative Stress;Oxygen;pathogen;Pathologic;Pathway interactions;Phenotype;prevent;Process;Proteins;Publications;Radiation;Radiation induced damage;Reaction;Reactive Oxygen Species;Role;Signal Pathway;Signal Transduction;Superoxide Dismutase;tempol;Thinness;Tissues;United States National Institutes of Health;Weight Gain;Weight maintenance regimen

PROJECT_TITLE: Nitroxides as Protectors Against Oxidative Stress


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Natural Products;Orphan Drug;Rare Diseases

PI_NAMEs: FIGG, WILLIAM DOUGLAS (contact)

PROJECT_TERMS: 3-Dimensional;Affect;Alkaloids;analog;angiogenesis;Angiogenesis Inhibition;Angiogenesis Inhibitors;Angiogenesis Pathway;Anti-Bacterial Agents;anti-cancer;anti-fungal agents;Anti-Inflammatory Agents;antiangiogenesis therapy;Antineoplastic Agents;Aorta;Attention;Binding;Biological;Biological Assay;Biological Markers;Biological Models;C-terminal;cancer therapy;Chemical Structure;chemotherapy;Chick Embryo;Clinical;Collaborations;Complex;Cysteine;Cytochrome P450;design;Development;Drug Design;drug development;Drug resistance;Drug Screening;Endothelial Cells;Energy Metabolism;EP300 gene;Exhibits;Fluorescence;Fluorine;glutarimide;high throughput screening;Histidine;Human;Hypoxia;Hypoxia Inducible Factor;hypoxia inducible factor 1;Imides;immune modulating agents;immunoregulation;improved;In Vitro;in vivo;in vivo Model;Inflammation;Inflammatory;inhibitor;interest;Invaded;Isoenzymes;Laboratories;Lead;lead candidate;Legal patent;Libraries;Malignant neoplasm of prostate;Malignant Neoplasms;marine;Measures;Metabolic Biotransformation;migration;Modeling;Molecular;Molecular Target;Multiple Myeloma;Natural Product Drug;Natural Products;Natural Products Chemistry;New Agents;New Zealand;novel;novel therapeutics;Patients;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Phthalimides;Play;Porifera;pre-clinical;Pre-Clinical Model;preclinical development;preclinical study;Preparation;Property;protein expression;protein protein interaction;Pyrroloiminoquinones;rational design;Rattus;Regimen;Relapse;Reporting;repository;Research;research clinical testing;Resistance;Role;Saphenous Vein;Scanning;secondary analysis;Series;small molecule inhibitor;Solid Neoplasm;spheroids;Structure;Structure-Activity Relationship;Synthesis Chemistry;targeted treatment;Thalidomide;Therapeutic;therapeutically effective;Time;Toxic effect;Transactivation;Tube;tumor;Tumor Angiogenesis;tumor growth;ubiquitin-protein ligase;United States National Institutes of Health;Viral;Western Blotting;Zebrafish

PROJECT_TITLE: Development of Anticancer Agents


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunotherapy;Infectious Diseases;Prevention

PI_NAMEs: YARCHOAN, ROBERT  (contact)

PROJECT_TERMS: AIDS related cancer;Anti-HIV Agents;Anti-HIV Therapy;anti-PD-1;anti-PD-L1;Binding;Collaborations;Development;Diagnosis;Goals;HIV;HIV Infections;HIV Protease;HIV resistance;HIV-1;HIV-1 integrase;Immune checkpoint inhibitor;Immune response;Impairment;Life Cycle Stages;Nature;novel;novel therapeutics;Nuclear Localization Signal;Oncology;Pathogenesis;Patients;pembrolizumab;Peptide Hydrolases;Pharmaceutical Preparations;Prevention strategy;Preventive therapy;Protease Inhibitor;Research;Resistance;Variant;Viral;Viral reservoir;Virus;Virus Diseases

PROJECT_TITLE: Development of Preventive Strategies and Therapy for HIV Infection


PI_NAMEs: MITSUYA, HIROAKI  (contact)

PROJECT_TERMS: Acetals;Acetates;Acquired Immunodeficiency Syndrome;Active Sites;Affect;Affinity;Amides;Annual Reports;Anti-Retroviral Agents;Anti-viral Therapy;antiretroviral therapy;antiviral drug development;Area;Aspartate;benzenesulfonamide;Binding;Binding Sites;Biological;Biological Assay;Carboxylic Acids;Cardiovascular Diseases;Cells;chloroacetate;Chronic;Clinical;Cyclosporine;Data;design;Development;Disease;drug development;Effectiveness;Elements;enantiomer;Enzyme Inhibition;Enzymes;Epidemic;Ethane;Evaluation;Exhibits;FDA approved;General Population;Genetic;high risk;HIV;HIV Infections;HIV resistance;HIV-1;HIV-1 drug resistance;HIV-1 protease;HIV-Associated Lipodystrophy Syndrome;HIV/AIDS;Hydrogen Bonding;Hydrophobicity;Hyperlipidemia;improved;indexing;Individual;Infection;inhibitor;inhibitor therapy;insight;Integrase;Lead;Life Expectancy;Ligand Binding;Ligands;Lipase;Lipids;Molecular;Molecular Conformation;Multi-Drug Resistance;mutant;nanomolar;non-nucleoside reverse transcriptase inhibitors;novel;Nucleosides;Optics;Oxygen;Patients;Peptide Hydrolases;Periodicity;Pharmaceutical Preparations;pharmacologic;Population;Prognosis;Protease Inhibitor;Proteins;Quality of life;Regimen;Reporting;Research;Resolution;Reverse Transcriptase Inhibitors;Risk Estimate;Roentgen Rays;scaffold;Series;Side;side effect;Signal Transduction;Stains;Structure;success;Sulfonamides;System;tetrahydrofuran;Treatment Failure;Treatment Protocols;Variant;Vertebral column;Viral;Viral Physiology;X-Ray Crystallography

PROJECT_TITLE: Development of Antiviral Therapy of HIV-1 Infection


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Orphan Drug;Pediatric;Pediatric - AIDS;Rare Diseases

PI_NAMEs: WILSON, WYNDHAM H (contact)

PROJECT_TERMS: Adverse effects;Advisory Committees;AIDS-Related Lymphoma;B-Cell Activation;B-Cell Lymphomas;B-Lymphocytes;Burkitt Lymphoma;Categories;Cells;chemotherapy;Cities;Classification;Clinical;Clinical Research;Clinical Trials;Collaborations;Consensus;Cytotoxic agent;Development;Dose;Doxorubicin;Drug Kinetics;Drug Targeting;druggable target;effective therapy;Elements;Empiricism;gene therapy;Genetic;Gray Zone Lymphoma;Hepatic;high risk;HIV;HIV Infections;Human Herpesvirus 4;immunodeficiency;Immunosuppression;Impairment;improved outcome;Incidence;indexing;Indolent;Inflammasome;insight;International;large cell Diffuse non-Hodgkin's lymphoma;lymphoid neoplasm;Lymphoma;Lymphoproliferative Disorders;Macrophage;Mantle Cell Lymphoma;Mediastinal;Molecular;Molecular Biology;molecular subtypes;Mycoses;NF-kappa B;novel;Outcome;Pathway interactions;Patients;Pharmacodynamics;Research;research study;Role;Schedule;Signal Transduction;standard of care;Structure of germinal center of lymph node;targeted agent;Therapeutic;therapy outcome;Thymus Gland;Toxic effect;Translating;translational study;treatment program;tumor DNA;Validation;Variant

PROJECT_TITLE: Therapeutic Strategies and Molecular Correlates in Aggressive B-cell Lymphomas


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Women's Health Research

PI_NAMEs: LIPKOWITZ, STANLEY  (contact)

PROJECT_TERMS: Adaptive Immune System;Agonist;Animals;Antibodies;Apoptosis;Binding Proteins;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Model;Breast Cancer Patient;Breast Cancer Treatment;cancer cell;cancer subtypes;Caspase;Cell Death;Cell Death Induction;cell killing;Cells;Cessation of life;chemotherapeutic agent;Clinical Trials;Collaborations;Combined Modality Therapy;Credentialing;Data;Drug Synergism;Drug usage;Endometrial Carcinoma;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Epigenetic Process;Family;functional genomics;Genes;Genetic;Induction of Apoptosis;Innate Immune System;Ligands;Malignant Breast Neoplasm;Mediating;member;Mitochondria;National Center for Advancing Translational Sciences;Necrosis;novel;novel drug class;Pathway interactions;Patients;Peptide Hydrolases;Pharmaceutical Preparations;Phase II Clinical Trials;pre-clinical;preclinical study;Protein Tyrosine Kinase;Proteins;receptor;recruit;Resistance;targeted agent;targeted treatment;TNF gene;TNFRSF10A gene;TNFRSF10B gene;TNFRSF1A gene;Toxic effect;Trastuzumab;tumor initiation;Tumor Necrosis Factor Ligand Superfamily Member 6;Tumor Necrosis Factor Receptor;Work

PROJECT_TITLE: Activating Cell Death Pathways in Breast Cancer Cells


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Cardiovascular;Infectious Diseases;Women's Health Research

PI_NAMEs: WINK, DAVID  (contact)

PROJECT_TERMS: 4T1;Adjuvant;Alzheimer's Disease;Antineoplastic Agents;Antioxidants;Antitumor Response;Biological;Biology;Biopsy;breast cancer progression;cancer therapy;cancer type;Cardiovascular Diseases;chemical reaction;Chemicals;Chemistry;Chemotherapy and/or radiation;Clinical Treatment;Clinical Trials;Collaborations;Communicable Diseases;Development;Disease;Disease Progression;DNA;DNA Repair;drug efficacy;Estrogen receptor negative;Future;genotoxicity;Goals;Growth;Heart Diseases;Heart failure;Hospitals;Immune system;improved;Inflammation;Inflammatory;Kinetics;Malignant Breast Neoplasm;Malignant Neoplasms;Mediator;Metabolic;Methodist Church;migration;Modeling;Myocardial Ischemia;Neoadjuvant Therapy;Nerve Degeneration;Nitric Oxide;Nitric Oxide Donors;Nitric Oxide Synthase;Nitric Oxide Synthetase Inhibitor;NOS2A gene;novel;novel therapeutic intervention;Oncogenic;Outcome;Oxidation-Reduction;Oxidative Stress;pathogen;Pathway interactions;Patients;Phase;preconditioning;Production;Prognosis;Proliferating;PTGS2 gene;Radiation therapy;Reactive Oxygen Species;Reperfusion Injury;Reperfusion Therapy;Reporting;Research;Research Personnel;Series;Siblings;Signal Transduction;Solid;stem;System;Thermodynamics;Time;Toxicology;triple-negative invasive breast carcinoma;tumor;Work;Xenograft Model

PROJECT_TITLE: Nitric Oxide as a Modifier of Oxidative Stress


PI_NAMEs: LEVENS, DAVID L. (contact)

PROJECT_TERMS: Active Sites;Acute;Affinity Chromatography;Binding;Binding Proteins;Binding Sites;Biological Assay;c-myc Genes;cancer cell;Cell Differentiation process;cell growth;Cells;Chromatin;Chromatin Loop;Chromatography;Development;DNA;DNA sequencing;Elements;experimental study;Feedback;Gene Expression;Genes;Genetic;Genetic Transcription;genome-wide;Genomics;Goals;Human;In Vitro;in vivo;insight;knock-down;Knock-in;Knock-out;Knockout Mice;Laboratories;Malignant Neoplasms;Measures;melting;Molecular;Molecular Conformation;Monitor;Mus;MYC gene;nanopore;Normal Cell;nuclease;Output;Pathologic;Pathology;Pathway interactions;Phase;Physical condensation;Physiologic pulse;Physiological;Preparation;prevent;promoter;Proteins;Pump;rapid test;Reaction;reconstitution;Regulation;response;Series;Signal Pathway;Signal Transduction;Site;Stress;System;Testing;Therapeutic;tool;Topoisomerase;transcription factor;transcription factor TFIIH;Transcriptional Activation;Work

PROJECT_TITLE: Mechanisms of transcription factor integration at the c-myc promoter


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Hematology;Immunotherapy;Radiation Oncology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

PI_NAMEs: ROBERTS, DAVID D (contact)

PROJECT_TERMS: Acute;adaptive immune response;Adult;Affect;aged;Agonist;aldehyde dehydrogenase 1;angiogenesis;Angiogenesis Inhibition;Angiogenesis Inhibitors;antagonist;Anthracycline;anti-tumor immune response;Antibodies;Antigen Presentation;Autophagocytosis;Blocking Antibodies;Blood flow;Blood Platelets;Blood Pressure;Bone Marrow;Breast Carcinoma;c-myc Genes;cancer cell;cancer immunotherapy;cancer stem cell;CD34 gene;CD47 gene;CD47-SIRPα;CD8-Positive T-Lymphocytes;Cell Line;Cell Surface Receptors;Cell Survival;Cells;Clinical Trials;Cyclic GMP;Cyclic GMP-Dependent Protein Kinases;cytotoxic;Data;DNA Repair;Epithelium;Erythrocytes;Erythroid;Erythropoiesis;Excision;Exhibits;Extracellular Matrix;Extramedullary;Family suidae;Flow Cytometry;Gene Expression;Genes;Genetic Transcription;Glycoproteins;Growth;Hemostatic function;Human;immune checkpoint;inhibiting antibody;innate immune checkpoint;Ionizing radiation;Irradiated tumor;Ischemia;ischemic injury;KDR gene;Knockout Mice;Ligands;Macrophage;Maintenance;Malignant Breast Neoplasm;Malignant Epithelial Cell;Malignant Neoplasms;Mammospheres;MDA MB 231;Mediating;Mesenchymal;Metabolism;mouse model;mRNA Expression;Multipotent Stem Cells;Mus;Myeloid Cells;Myocardium;Natural Killer Cells;Neoplasm Metastasis;neoplastic cell;Nitric Oxide;Non-Malignant;NOS3 gene;novel;Null Lymphocytes;Pathway interactions;Phagocytes;Play;progenitor;Prognosis;Proliferating;protein expression;PTPN6 gene;PTPNS1 gene;Radiation Injuries;radiation resistance;Rattus;receptor;Recombinants;Recovery;Regulation;Reperfusion Injury;Reporting;response;Role;self-renewal;SHPS-1 protein;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Smooth Muscle Myocytes;soft tissue;Soluble Guanylate Cyclase;Spleen;stem cells;Stromal Cells;T-Lymphocyte;Therapeutic;Thrombospondin 1;Thrombospondins;tissue culture;tissue stress;Tissue Survival;Tissues;transcription factor;transcriptome;Transgenic Mice;transmission process;treatment response;tumor;Tumor Immunity;tumor progression;tumor xenograft;Vascular Smooth Muscle;Wild Type Mouse

PROJECT_TITLE: Cellular Interactions with Thrombospondin


NIH_SPENDING_CATS: Cancer;Immunotherapy;Skin Cancer

PROJECT_TERMS: adaptive immune response;Aging;Anabolism;anti-CTLA4;Antibodies;Antigens;antiviral immunity;autocrine;Autoimmune Diseases;B-Lymphocytes;Biological Markers;Blood Platelets;CD47 gene;cell behavior;Cell Differentiation process;Cell Surface Receptors;cell type;Cells;checkpoint therapy;Communicable Diseases;CTLA4 gene;cytokine;Cytotoxic T-Lymphocytes;Dendritic Cells;Development;Eating;Extracellular Matrix;Extracellular Space;FDA approved;Glycoproteins;Human;Hydrogen Sulfide;Hyperglycemia;Immune;Immune checkpoint inhibitor;Immune response;Immunity;Immunocompetent;Immunosuppression;In Vitro;in vivo;Inflammatory;Injury;Innate Immune Response;insight;Interleukin-2;ipilimumab;irradiation;Ischemia;Macrophage;Mediating;Mediator;Melanoma;Melanoma Cell;Modeling;Mus;nanomolar;Natural Killer Cells;neoplastic cell;neutrophil;new combination therapies;Nitric Oxide;NK Cell Activation;Patients;Phagocytosis;Physiological;Plasma;Production;Prognostic Marker;receptor;Receptor Signaling;Reporting;response;Role;SHPS-1 protein;Signal Transduction;Stress;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Therapeutic;Thrombospondin 1;Transforming Growth Factor beta;translational applications;tumor;Tumor Immunity;tumor immunology;tumor microenvironment;Vascular Endothelial Growth Factors;Work

PROJECT_TITLE: Roles of CD47 Signaling in Tumor Immunology


NIH_SPENDING_CATS: Cancer

PI_NAMEs: STETLER-STEVENSON, WILLIAM  (contact)

PROJECT_TERMS: Acute Disease;Alanine;Angiogenesis Inhibitors;Apoptosis;Basement membrane;Behavior;Biological;Breast Cancer cell line;C-terminal;cancer cell;cell growth;cell motility;Cell Physiology;Cell surface;Cell Surface Receptors;cell type;Chronic Disease;Complex;Cultured Tumor Cells;Data;Development;Disintegrins;Disulfides;Elements;Endothelium;Enzyme Inhibitor Drugs;Enzymes;Equilibrium;experimental study;Extracellular Matrix;Family;Fibroblasts;fibrosarcoma;Future;Gelatinase A;gene product;Genes;Glioblastoma;Goals;Growth;Growth Factor;Growth Factor Inhibition;Human;In Vitro;in vivo;Inhibition of Matrix Metalloproteinases Pathway;inhibitor;Interstitial Collagenase;Invaded;Investigation;Laboratories;link protein;Lung;lung cancer cell;Matrix Metalloproteinase Inhibitor;Matrix Metalloproteinases;Mediating;member;Metalloproteases;Methods;migration;MMP14 gene;MMP9 gene;N-Glycosylation Site;N-terminal;Neoplasm Metastasis;neoplastic cell;Normal tissue morphology;novel;Pathology;Physiology;prevent;Protease Inhibitor;Proteins;Receptor Protein-Tyrosine Kinases;Reporting;Research;Residual state;Role;Signal Pathway;Signal Transduction;Tail;Therapeutic;Thrombospondins;TIMP2 gene;TIMP3 gene;Tissue Inhibitor of Metalloproteinase-1;Tissue Inhibitor of Metalloproteinases;Tissues;tumor;tumor microenvironment;tumor progression;tumorigenic;Vascular Endothelial Cell;Zinc

PROJECT_TITLE: The Role of TIMPs in Cell Growth, Tumor Progression and Metastasis


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Genetics;Prostate Cancer;Urologic Diseases

PI_NAMEs: NECKERS, LEONARD  (contact)

PROJECT_TERMS: Address;Alternative Splicing;androgen independent prostate cancer;Androgen Receptor;Androgens;Anti-androgen Therapy;Area;Binding;cancer site;Carbon;Castration;Cells;Citric Acid Cycle;Client;Collaborations;Compensation;Complex;Dependence;deprivation;Development;drug development;Electron Transport;enzalutamide;Genetic Transcription;glucose uptake;Glutamine;Heat-Shock Proteins 70;Heat-Shock Proteins 90;Homologous Gene;HSF1;In Vitro;in vivo;inhibitor;Knock-out;Length;Ligand Binding Domain;magnetic resonance spectroscopic imaging;Magnetic Resonance Spectroscopy;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mediating;Metabolic;Mitochondria;Molecular Chaperones;monomer;Neoplasm Metastasis;non-invasive imaging;novel;novel strategies;Oncogenic;Outcome;Oxidative Phosphorylation;Pharmaceutical Preparations;Phenocopy;Phosphotransferases;preference;Production;programs;Prostate;Proteins;Publications;Pyruvate;Regulation;Renal Carcinoma;Reproducibility;Research;Residual state;Resistance;Respiration;RNA Splicing;Role;Signal Transduction;Source;Translations;Urologic Diseases

PROJECT_TITLE: HSP90 and HSP70 Chaperone Proteins and Interactors in Cellular Signal Transduction


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Esophageal Cancer;Genetics;Human Genome;Immunization;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Vaccine Related

PI_NAMEs: SCHRUMP, DAVID  (contact)

PROJECT_TERMS: Aberrant DNA Methylation;Adjuvant Therapy;Adoptive Immunotherapy;aerosolized;Antigen Presentation Pathway;Antigens;Apoptosis;Azacitidine;Biodistribution;BMX gene;cancer cell;Cancer Center;Cancer Patient;cancer stem cell;cancer/testis antigen;Cell Separation;Cells;chromatin remodeling;Chromatin Structure;Chronic;Clinical;Clinical Protocols;Clinical Trials;COVID-19 pandemic;cytokine;Data;Decitabine;demethylation;derepression;DNA;DNA Methylation;Drug Kinetics;Drug Stability;Early Diagnosis;epigenetic drug;Epigenetic Process;epigenetic therapy;epigenomics;Evaluation;Event;Exhibits;experience;first-in-human;Gene Expression;Genes;Germ Lines;Goals;Growth;Hawaii;HDAC8 gene;Histone Deacetylase Inhibitor;Histone-Lysine N-Methyltransferase;Histones;Human;immune checkpoint blockade;Immune response;Immunocompetent;immunogenicity;Immunosuppression;Immunotherapy;In Vitro;in vivo Model;Individual;Inhalation;inhibitor;Institution;Interleukin-12;Interleukin-15;International;Intervention;laboratory experiment;Life;liquid biopsy;Lung;Malignant - descriptor;Malignant neoplasm of esophagus;Malignant neoplasm of lung;Malignant neoplasm of thorax;Malignant Neoplasms;Malignant Pleural Mesothelioma;Manuscripts;Mediating;Mesothelial Cell;Mesothelioma;Metastatic Neoplasm to the Lung;minimally invasive;Modeling;Modification;Molecular;Mus;Mutation;Neoadjuvant Therapy;Neoplasm Metastasis;Neoplasms;Nivolumab;Non-Small-Cell Lung Carcinoma;Normal Cell;Nucleosomes;Operative Surgical Procedures;Oral;Oral Examination;Participant;Pathway interactions;Patients;Peer Review;pembrolizumab;Perioperative;Pharmaceutical Preparations;Phase;Phase I/II Clinical Trial;phase II trial;Positioning Attribute;preclinical study;prevent;programs;Proteins;Protocols documentation;Publications;Publishing;radiological imaging;Regimen;response;Scanning;Series;symposium;Syndrome;systemic toxicity;Techniques;Testis;Tetrahydrouridine;Thoracic Neoplasms;Thoracic Oncology;Toxic effect;TP53 gene;Translational Research;Treatment Protocols;treatment response;tumor;Tumor Suppressor Genes;Universities;Vaccines;virtual;Writing

PROJECT_TITLE: Epigenetic Therapy for Thoracic Malignancies


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Neurofibromatosis;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

PI_NAMEs: WIDEMANN, BRIGITTE  (contact)

PROJECT_TERMS: Acceleration;Achievement;Adolescent;Adult;Age;Atlases;Benign;Biological Markers;Biology;Biopsy;cell free DNA;Cells;Child;Childhood;Clinic;Clinical;Clinical Investigator;Clinical Trials;Clinical Trials Network;Collaborations;Combined Modality Therapy;Country;Cutaneous;Data;Decision Making;Development;Developmental Therapeutics Program;Disease remission;Dose;drug development;drug discovery;Early Intervention;early phase clinical trial;Educational workshop;effective therapy;Enrollment;Evaluation;Excision;Extramural Activities;functional outcomes;Funding;Genetic;Genetic Predisposition to Disease;Goals;Growth;high risk;Histologic;hyperactive Ras;Image;inhibitor;innovation;insight;Intervention;Intervention Trial;Knowledge;Lesion;Liquid substance;Location;Magnetic Resonance Imaging;Malignant - descriptor;Malignant Childhood Neoplasm;Malignant Neoplasms;Manuscripts;Measurement;Medical;MEKs;Mission;Molecular;Morbidity - disease rate;Natural History;neurofibroma;Neurofibromatoses;Neurofibromatosis 1;Neurofibrosarcoma;Nodular Lesion;novel;novel therapeutics;participant enrollment;Pathogenesis;Pathologic;Pathway interactions;Patient Care;Patients;Pediatric Oncology;Pediatric Oncology Group;Peripheral Nerve Sheath Neoplasm;Persons;pet animal;Pharmacodynamics;Phase;phase I trial;phase II trial;Plexiform Neurofibroma;Population;Positioning Attribute;Predisposition;premalignant;prevent;Prevention;Prevention strategy;Prevention trial;programs;rare cancer;Recommendation;Refractory;refractory cancer;Registries;Reporting;Research Personnel;Resources;response;Risk;Sarcoma;Science;Secondary Prevention;Series;Site;Solid Neoplasm;Syndrome;targeted agent;targeted treatment;therapy development;Toxic effect;treatment strategy;trial design;tumor;United States;United States National Institutes of Health;young adult

PROJECT_TITLE: Therapies for patients with rare tumors and genetic tumor predisposition


PI_NAMEs: TOSATO, GIOVANNA  (contact)

PROJECT_TERMS: angiogenesis;Angiogenesis Inhibitors;Angiogenic Factor;Biochemical;Blood Cells;cancer care;cancer cell;Cancer Model;Cancer Patient;cancer therapy;cell growth;Cell Physiology;Characteristics;chemotherapy;Clinic;Complex;Development;Drug Targeting;Endothelial Cells;Endothelial Growth Factors;Epigenetic Process;Extracellular Matrix;Genetic;Goals;Heterogeneity;Immune Targeting;Individual;Knowledge;Link;Malignant Neoplasms;Metabolic;migration;Neoplasm Metastasis;neoplastic cell;new therapeutic target;Nutrient;Oxygen;Performance;Pericytes;Pharmaceutical Preparations;Physiological;pre-clinical;Process;receptor;recruit;Research;Resistance;Signal Transduction;Site;targeted treatment;Testing;Therapeutic;therapeutic target;Time;treatment response;tumor;Tumor Angiogenesis;Tumor Expansion;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Vascular blood supply;Vascular Endothelial Growth Factors;VEGFA gene

PROJECT_TITLE: Angiogenesis and Tumor Growth


NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;HIV/AIDS;Hematology;Immunotherapy;Infectious Diseases;Lung;Lung Cancer;Lymphatic Research;Lymphoma;Rare Diseases

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;AIDS related cancer;angiogenesis;Angiogenesis Inhibitors;body cavity;cancer type;Cause of Death;cell growth;Cell Proliferation;Cells;Clinical;cytokine;Development;Dose;Drug Targeting;Endothelial Cells;Environment;Environmental Risk Factor;experimental study;Exposure to;Genes;Genetic;Goals;HIV Infections;HIV/AIDS;Hodgkin Disease;Human;Human Herpesvirus 8;Immunity;improved;Inflammatory;interest;Kaposi Sarcoma;lenalidomide;Leukemic Cell;Link;Lymphatic Endothelial Cells;Lymphoma cell;Malignant neoplasm of lung;Malignant Neoplasms;Molecular;Multicentric Angiofollicular Lymphoid Hyperplasia;Mus;mutant;Mutant Strains Mice;Nature;novel therapeutics;Oryctolagus cuniculus;Pathogenesis;patient population;Patients;Pharmaceutical Preparations;pomalidomide;primary effusion lymphoma;Process;Proliferating;Proteins;Reporting;Research;Role;Signal Transduction;success;Syndrome;T-Lymphocyte;Testing;Thalidomide;Therapeutic;Time;Tissues;tumor;Tumor Angiogenesis;tumor progression;Tumor Promotion;tumorigenic;Vascular Endothelial Cell;Viral;virus related cancer;Work

PROJECT_TITLE: A Role for KSHV in the Pathogenesis of Malignancies


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Cervical Cancer;Digestive Diseases;Emerging Infectious Diseases;Genetics;HIV/AIDS;Hematology;Human Genome;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases;Sexually Transmitted Infections;Women's Health Research

PI_NAMEs: ZHENG, ZHI-MING  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adenosine;Alternative Splicing;Animal Model;B-Cell Lymphomas;B-Lymphocytes;Binding;biomarker identification;body cavity;cancer gene expression;carcinogenesis;CASP7 gene;Cell Proliferation;cell transformation;Cells;Cervical dysplasia;Chromosomes;chronic infection;clinical diagnosis;clinical prognosis;Code;cytokine;Development;dimer;DNA Tumor Viruses;Elements;Exons;Gene Expression;Genes;Genetic Transcription;Genome;genome-wide;Goals;Gossypium;Herpesviridae Infections;high risk;HIV;hnRNP A1;HPV E7;HPV-High Risk;Human Herpesvirus 8;Human papilloma virus infection;Human Papillomavirus;Human papillomavirus 16;IL6 gene;Infection;Inflammation;Interleukin-10;Interruption;Introns;Kaposi Sarcoma;Laboratories;Lesion;Lytic;Lytic Phase;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;Malignant Neoplasms;malignant oropharynx neoplasm;Mediating;MicroRNAs;Modeling;monomer;mRNA Precursor;Multicentric Angiofollicular Lymphoid Hyperplasia;Mus;Natural Immunity;Oncogenic;Oncogenic Viruses;Open Reading Frames;Oryctolagus cuniculus;overexpression;Papillomavirus;Papillomavirus Infections;Papillomavirus Transforming Protein E6;Patients;Play;Post-Transcriptional Regulation;posttranscriptional;pre-clinical;Pre-mRNA Polyadenylation Factor;primary effusion lymphoma;Production;Proteins;Proto-Oncogenes;Regulation;RNA;RNA Caps;RNA Instability;RNA Splicing;RNA-Binding Proteins;RNA-Protein Interaction;Role;Series;Sexual Transmission;Site;Spliceosomes;Stress;stress granule;Structure;Study models;Tail;Therapeutic;Transcript;Translation Initiation;Translational Repression;Translations;tumor;Tumor Suppressor Proteins;Untranslated RNA;Viral;viral carcinogenesis;viral DNA;Viral Oncogene;viral RNA;virology;Virus Integration

PROJECT_TITLE: Gene Expression and Post-Transcriptional Regulation of DNA Tumor Viruses


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Data Science;Genetic Testing;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

PI_NAMEs: KHAN, JAVED  (contact)

PROJECT_TERMS: Artificial Intelligence;Attention;biomarker development;cancer genomics;Classification;Clinical;convolutional neural network;Data;deep learning;Diagnosis;DNA analysis;DNA Sequence Alteration;driver mutation;Event;Genes;Genetic;Germ Lines;Goals;Hematoxylin and Eosin Staining Method;Histologic;Image;improved;large language model;Malignant Childhood Neoplasm;Maps;Modeling;Molecular;molecular subtypes;Morphology;multimodality;Neural Network Simulation;next generation sequencing;Outcome;outcome prediction;Pathway interactions;Patients;Play;predicting response;predictive modeling;Prognosis;Proteomics;Rhabdomyosarcoma;risk prediction;Role;therapeutic target;Time;tumor DNA

PROJECT_TITLE: Predicting Response and Prognosis in Pediatric Cancers


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

PI_NAMEs: CAMPHAUSEN, KEVIN  (contact)

PROJECT_TERMS: Affect;Biogenesis;Biology;blood-brain barrier penetration;Characteristics;Clinic;Clinical;Clinical Trials;clinically relevant;Collaborations;Development;DNA;Dose;Drug Delivery Systems;Drug Kinetics;drug testing;experience;Failure;FDA approved;Functional disorder;Glioblastoma;Goals;Histone Deacetylase Inhibitor;Image;improved;In Vitro;in vivo;inhibitor;irradiation;Megakaryocytes;metabolic imaging;Metabolism;MGMT gene;Modeling;Molecular;National Center for Advancing Translational Sciences;novel;novel marker;Patients;Pharmaceutical Preparations;Pharmacology;pre-clinical;preclinical development;preclinical study;predictive modeling;Primary Neoplasm;programs;Proteins;Publishing;Radiation therapy;Radiation-Sensitizing Agents;Reaction Time;Recurrence;response;Ribosomes;Role;Testing;Toxicology;Translating;Translations;tumor;Work

PROJECT_TITLE: Pre-clinical Development of Radiation Sensitizers for Patients with Glioblastoma


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Patient Safety;Radiation Oncology

PROJECT_TERMS: Address;Agreement;arm;Biopsy;Brain Neoplasms;brain volume;Cancer Therapy Evaluation Program;chemotherapy;Clinic;Clinical;clinical care;clinical center;clinical development;Clinical Trials;clinically relevant;cohort;Collaborations;Common Terminology Criteria for Adverse Events;Cooperative Research and Development Agreement;Data;Databases;Development;DNA;Dose;European Organization for Research and Treatment of Cancer;Excision;follow-up;Image;improved;Industry;inhibitor;Intramural Research Program;irradiation;Location;Long-Term Survivors;Magnetic Resonance Imaging;Modernization;Molecular Target;Morbidity - disease rate;Nature;Neurologic Symptoms;Neurology;Newly Diagnosed;Newly Diagnosed Disease;novel;novel therapeutics;Pain;Patient imaging;Patients;Pattern;Performance Status;Pharmaceutical Preparations;Pharmacologic Substance;Phase;phase 1 study;phase 3 study;phase II trial;phase III trial;preclinical study;Publications;Publishing;Radiation;Radiation Dose Unit;Radiation therapy;Radiation Therapy Oncology Group;Radiation-Sensitizing Agents;radiological imaging;Recommendation;Recurrence;Recurrent tumor;Reporting;Research;response;Role;Running;Scheme;standard of care;Structure;success;synergism;Systemic Therapy;targeted agent;Time;time interval;Toxic effect;Translating;tumor;United States National Institutes of Health;Valproic Acid;Work

PROJECT_TITLE: The Synergy Between Radiotherapy and Molecularly Targeted Agents


NIH_SPENDING_CATS: Cancer;Genetics

PI_NAMEs: SINGER, DINAH S. (contact)

PROJECT_TERMS: 26S proteasome;Affect;Alanine;Binding;Biogenesis;Biological Assay;Biological Process;Breast Cancer cell line;cancer cell;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell Line;Cell Nucleus;Cell Physiology;Cell Proliferation;Cell Survival;cell type;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Cytoplasm;Dissociation;DNA;DNA Polymerase II;DNA-Directed RNA Polymerase;embryo cell;Endosomes;Event;experimental study;Future;Gene Expression;Gene Expression Regulation;Genetic Transcription;Goals;Heat-Shock Proteins 70;Immunoprecipitation;In Vitro;in vivo;Individual;insight;interest;Maps;Mediating;Mediator;melting;Molecular;Molecular Chaperones;Molecular Conformation;Multiprotein Complexes;Mus;mutant;Mutate;Mutation;Nucleotides;Peripheral;Phenotype;Phosphorylation;Phosphotransferases;Play;Point Mutation;Polyribosomes;Post-Translational Modification Site;Post-Translational Protein Processing;Productivity;programs;Proliferating;promoter;Protein Biosynthesis;Proteins;recruit;Recycling;Regulation;Reporting;Research;Rest;RNA;RNA Binding;RNA chemical synthesis;RNA Splicing;RNA Transport;Role;Series;Signal Transduction;Site;STAT3 gene;success;TAF1 gene;TAF7 gene;Technology;thymocyte;TP53 gene;trafficking;Transcript;Transcription Elongation;transcription factor;transcription factor TFIIE;transcription factor TFIIF;transcription factor TFIIH;Transcription Initiation;Transcription Process;Transcriptional Regulation;Transgenic Mice;Translations

PROJECT_TITLE: TAF7: A Check-point Regulator in Transcription Initiation and Translation


NIH_SPENDING_CATS: Breast Cancer;Cancer;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Women's Health Research

PI_NAMEs: LIU, ZHENG-GANG  (contact)

PROJECT_TERMS: Achievement;Acquired Immunodeficiency Syndrome;Acute;anti-cancer research;Antineoplastic Agents;Apoptosis;apoptosis inducing factor;Apoptotic;Arthritis;Autoimmune Diseases;Binding;Biological;Breast Cancer Model;cancer therapy;cancer type;CD8-Positive T-Lymphocytes;Cell Death;Cell Death Induction;Cell Proliferation;Cell surface;Cell Surface Proteins;Cells;Cessation of life;Chronic;chronic inflammatory disease;COVID-19;COVID-19 treatment;Crohn's disease;cytokine;cytokine release syndrome;cytotoxicity;Data;deprivation;Development;Diagnosis;Disease;Dose;E-Cadherin;Equilibrium;Event;Future;genetic regulatory protein;Glucose;Goals;Human;Immune;improved;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Knowledge;KRAS2 gene;Laboratories;Life;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Mediator;Molecular;Mus;Necrosis;Neoplasm Metastasis;neoplastic cell;novel;Pathogenesis;Pathology;Pathway interactions;Peptide Hydrolases;Physiological;Play;Production;Proteins;receptor;Regulation;Research;response;Rheumatoid Arthritis;Role;Septic Shock;Signal Pathway;Signal Transduction;Specific qualifier value;T-Lymphocyte;Therapeutic;Therapeutic Agents;Thrombosis;Tissues;TNF gene;Transforming Growth Factors;Translating;tumor;Tumor Promotion;tumorigenesis;Virus Diseases;Work

PROJECT_TITLE: TNF Signaling, Cell Death and Cancer


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Genetics;Hematology;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: APLAN, PETER  (contact)

PROJECT_TERMS: Acute Myelocytic Leukemia;Aneuploidy;Animal Model;Animals;Cell Line;Cells;chemotherapy;Childhood Acute Myeloid Leukemia;Chromosomal translocation;chromosome missegregation;Chromosomes;Clinical;Collaborations;Development;efficacy evaluation;experimental study;FLT3 gene;fusion gene;gene cloning;Generations;Genes;Genetic;Hematologic Neoplasms;Hematopoietic;Hematopoietic stem cells;in vivo;inhibitor;Lesion;leukemia;Link;Malignant - descriptor;Malignant Neoplasms;Manuscripts;Menin;Mus;Mutate;Mutation;Nodal;novel;NUP98 gene;Oncogenic;overexpression;Patients;pediatric patients;Point Mutation;premalignant;Process;Proto-Oncogenes;Publishing;Recurrence;response;Testing;Time;TP53 gene;Transgenic Mice;Translocation Breakpoint;Transplantation;Yeasts

PROJECT_TITLE: Activation of Proto-Oncogenes by Chromosomal Translocation


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases

PROJECT_TERMS: ABCB1 gene;Acute Myelocytic Leukemia;Acute T Cell Leukemia;acute T-cell lymphoblastic leukemia cell;B-Lymphocytes;Biological Assay;Biological Models;cancer cell;CCR;CDKN1A gene;Cell Line;Cells;Chemoresistance;chemotherapy;childhood sarcoma;Chromosomal Rearrangement;Chromosomal translocation;Clonal Expansion;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Cytarabine;Cytidine;Cytosine;Development;Distant;DNA;DNA copy number;DNA Double Strand Break;DNA Insertion Elements;DNA Methyltransferase Inhibitor;driver mutation;Event;exome sequencing;experimental study;Frequencies;fusion gene;Fusion Oncogene Proteins;Genes;Genetic Transcription;Genome;Genomic Segment;genotoxicity;Goals;Human;In Vitro;in vitro Assay;in vivo Model;Induced Mutation;interstitial;leukemia;Link;Lymphoblastic Leukemia;Malignant - descriptor;Malignant Childhood Neoplasm;Malignant Neoplasms;Manuscripts;Mediating;Methotrexate;Methylation;Mitochondria;Molecular;Mus;Mutagens;Mutation;NF1 gene;novel;Nuclear;Oncogenes;Oncogenic;Phenotype;Phosphorylation;Phosphotransferases;Point Mutation;Pre-Clinical Model;Preparation;prevent;Production;Proto-Oncogenes;PTEN gene;Publishing;Recurrence;repaired;Reproducibility;Resistance;Resistance development;RNA;Role;Single Nucleotide Polymorphism;Structure;T-Cell Leukemia;T-Lymphocyte;thyroid neoplasm;Tumor Suppressor Genes;Vincristine

PROJECT_TITLE: Mutation Mechanisms Leading to Malignant Transformation, Including Chromosomal Translocation and Point Mutations


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Gene Therapy;Genetics;Hematology;Orphan Drug;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PI_NAMEs: HICKSTEIN, DENNIS  (contact)

PROJECT_TERMS: Allogenic;Animal Model;Autologous;Bone Marrow;Bone Marrow Cells;Bone Marrow Stem Cell;canine model;Canis familiaris;Cells;Child;clinical phenotype;Clinical Trials;Complication;conditioning;Defect;Detection;Disease;disease phenotype;Dog Diseases;donor stem cell;Engraftment;Flow Cytometry;Future;gene correction;Gene Expression;Gene Modified;gene replacement;gene therapy;Gene Transfer;gene transfer vector;Generations;Genetic;Genetic Diseases;genotoxicity;graft vs host disease;Hematopoietic;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Homologous Transplantation;Human;immune reconstitution;Individual;ITGB2 gene;Lentivirus Vector;Leukocyte Adhesion Deficiency;Leukocytes;Membrane;Methods;Modeling;Patients;Pre-Clinical Model;promoter;receptor;Regimen;Retroviral Vector;Spumavirus;stem cell biology;stem cell gene therapy;Study models;success;Surface;Testing;Transgenes;Transplantation;vector;Viral;Viral Genes;Viral Vector

PROJECT_TITLE: Hematopoietic Stem Cell Gene Therapy for Leukocyte Adhesion Deficiency


ACTIVITY: ZIC

ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering

PI_NAMEs: GADINA, MASSIMO  (contact)

PROJECT_TERMS: Acoustics;Aerosols;Area;assay development;ATAC-seq;atopy;Autoimmune Diseases;bench to bedside;Biological Sciences;Biology;bone;Bone Diseases;cell analyzer;Cell fusion;Cell Separation;Cells;ChIP-seq;Clinical;Clinical Investigator;Clinical Research;Color;color detection;Computer software;computerized;Consultations;Contractor;Core Facility;Cytometry;Data;data acquisition;Data Analyses;Data Science;Dedications;Deposition;design;Detection;detector;developmental disease;Dimensions;Discipline;Doctor of Philosophy;Electronics;Equipment;Equipment and supply inventories;experience;Fellowship;flexibility;Flow Cytometry;Functional disorder;Goals;high dimensionality;high resolution imaging;Human;Human Resources;Hypersensitivity;Image;Image Analysis;imaging capabilities;Imaging technology;Immune;Immune System Diseases;Immunology;Immunophenotyping;Instruction;instrument;instrumentation;Interest Group;International;Intramural Research Program;Laboratories;Lasers;Leadership;Learning;meetings;Mid-Atlantic Region;Mission;Modernization;Morphology;multiple omics;Muscle;Myopathy;National Heart, Lung, and Blood Institute;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;new technology;novel;operation;Optics;Patients;peer;Policies;Population;Postdoctoral Fellow;Proteins;Research;research and development;Research Personnel;Research Project Grants;Research Support;Safety;Sampling;Scanning;Scientist;Services;single-cell RNA sequencing;Skin;skin disorder;Societies;Sorting;Specimen;System;Techniques;Time;Training;Training Technics;transcriptome sequencing;Tube;United States National Institutes of Health;Vendor

PROJECT_TITLE: Flow cytometry support to research in immune, skin, muscle and bone  diseases


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Data Science;Diabetes;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Lupus;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Rare Diseases;Rheumatoid Arthritis;Wound Healing and Care

ORG_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

PI_NAMEs: SUN, HONG-WEI  (contact)

PROJECT_TERMS: Active Sites;Address;Adult-Onset Still's Disease;Affect;age effect;Alternative Splicing;Amino Acids;Analysis of Variance;analysis pipeline;Apoptosis Promoter;Architecture;Area;Arteritis;Arthritis;Artificial Intelligence;ATAC-seq;Autoimmune Diseases;BCL2L1 gene;Benign;big biomedical data;Bioinformatics;Biological Assay;Biomedical Research;bisulfite sequencing;Blood;Blood coagulation;Bone Diseases;Calcinosis;CCL21 gene;CD3 Antigens;CD4 Positive T Lymphocytes;CDC2 gene;Cell Differentiation process;Cell Line;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Child;ChIP-seq;Chromatin;Cleavage Under Targets and Release Using Nuclease;Clinical;Clone Cells;cohesin;cohort;collaborative environment;Colon Carcinoma;comparison control;Complications of Diabetes Mellitus;Computational Biology;Computer Models;Consultations;coronavirus disease;COVID-19;COVID-19 vaccine;crosslinking and immunoprecipitation sequencing;Data;Data Analyses;Data Science;Data Set;data standards;data submission;data wrangling;Dedications;deep learning model;density;design;Detection;Development;Diabetic Foot Ulcer;Diabetic mouse;diabetic ulcer;Diagnosis;Disease;Disease remission;Disseminated eosinophilic collagen disease;DNA sequencing;DNA Sequencing Facility;Drug resistance;Ectopic Expression;empowerment;Enhancers;Ensure;Epidermis;Event;Exhibits;experience;Experimental Designs;Exposure to;Female;Flare;Fostering;gain of function;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;Genetic Markers;Genetic Transcription;Genome;genome sequencing;genome-wide;genomic data;Genomics;Germ-Line Mutation;global run on sequencing;granulocyte;healing;high dimensionality;histone modification;Homeostasis;Immune;Immune System Diseases;Individual;Inflammation;inhibitor;Injury;innovation;Interferons;Intramural Research Program;Introns;Investigation;JAK1 gene;Joints;Junk DNA;keratinocyte;Knock-out;large cell Diffuse non-Hodgkin's lymphoma;Linear Models;Lupus;lymph nodes;Lymphocyte;male;Malignant Neoplasms;Manuscripts;Maps;Mentors;Merkel cell carcinoma;Methodology;Methods;microbiome;MicroRNAs;Mining;Modeling;mouse model;Multiomic Data;multiple omics;Mus;Muscle;muscle progenitor cell;Mutation Analysis;Myopathy;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Natural History;neutrophil;next generation sequencing;novel;old mice;oral cavity epithelium;Pathogenicity;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Pharmacotherapy;Play;potential biomarker;Process;programs;promoter;Prospective Studies;protein function;Proteins;Quality Control;random forest;rare variant;Regulation;Relapsing polychondritis;Research;Research Personnel;Research Project Grants;response;Rheumatoid Arthritis;RNA Splicing;Role;Sampling;SARS-CoV-2 infection;Scientific Advances and Accomplishments;Scleroderma;single cell analysis;single cell ATAC-seq;single-cell RNA sequencing;Skin;Skin wound healing;Somatic Mutation;Spondylarthritis;Structure;success;systemic autoimmune disease;systemic juvenile idiopathic arthritis;Systemic Lupus Erythematosus;T cell differentiation;Techniques;Technology;Testing;three dimensional structure;Time;Tissue-Specific Gene Expression;tool;Training;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;transcriptomics;Transgenic Mice;tumor progression;Vaccination;Variant;Vasculitis;Vision;whole genome;Wild Type Mouse;Withholding Treatment;wound;wound healing

PROJECT_TITLE: Applying Bioinformatics to Research in Immune, Muscle, and Bone Diseases


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Genetics;Human Genome;Immunotherapy;Lupus;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: DELL'ORSO, STEFANIA  (contact)

PROJECT_TERMS: Adult;alpha ketoglutarate;Autoantibodies;Autoimmune Diseases;autoinflammatory diseases;Biological Assay;Bone Diseases;Cell Lineage;Cell Maintenance;Cells;CHD4 gene;Chromatin;Collaborations;Data Analyses;Data Collection;data sharing;derepression;Dermatomyositis;DNA sequencing;early onset;Embryonic Induction;embryonic stem cell;Enhancers;Ensure;Epigenetic Process;epigenomics;Experimental Designs;experimental study;Genes;genetic risk factor;Genetic Transcription;Genome;Genomic approach;Genomics;Glutamine;Idiopathic Inflammatory Myopathies;Immune checkpoint inhibitor;instrumentation;Libraries;Mentors;Merkel cell carcinoma;Mesoderm;Metabolism;MicroRNAs;Mining;Molecular;Molecular Biology;multidisciplinary;multiple omics;Mus;Muscle;Muscle Fibers;muscle progenitor cell;Myopathy;Myositis;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Natural regeneration;neutrophil;notch protein;NuRD complex;Pathogenesis;pathogenic autoantibodies;Patients;Polycomb;Preparation;Process;Protocols documentation;Publications;Publishing;Quality Control;Regulation;Research;Research Personnel;Research Project Grants;Resolution;RNA;Role;Services;Signal Transduction;single cell sequencing;Skin;skin disorder;Somatic Mutation;Specific qualifier value;stem cells;syntax;Systemic Lupus Erythematosus;Technology;Training;transcriptome;transcriptome sequencing;transcriptomic profiling;transcriptomics;United States National Institutes of Health

PROJECT_TITLE: High Throughput Next Generation Sequencing, Single-Cell Omics and Spatial Transcriptomic: supports genomics and epigenomics research in muscle, skin, bone and autoimmune diseases


ORG_NAME: DIVISION OF BASIC SCIENCES - NCI

PI_NAMEs: CROSSMAN, ASSIATU  (contact)

PROJECT_TERMS: anti-cancer research;Antigen-Presenting Cells;Apoptosis;Area;B cell repertoire;B-Cell Activation;B-Lymphocytes;Basic Science;Biological Assay;Biology;Blood Cells;Cancer Research Project;Cell Cycle;Cell Death;Cell Lineage;Cell membrane;Cell Physiology;cell preparation;Cell Proliferation;Cell Separation;Cell surface;Cell Survival;Cells;Cellular biology;CISH gene;Computer software;Consultations;Core Facility;Cost efficiency;Cultured Cells;Custom;Cytokine Signaling;Data;Data Analyses;Defect;Development;Electronics;Epithelial Cells;Evaluation;Event;Experimental Autoimmune Encephalomyelitis;Experimental Designs;Flow Cytometry;FOXO1A gene;Gene Expression Regulation;Generations;Genetic Transcription;Genetically Modified Animals;Goals;Histocompatibility Antigens;Immune;Immunobiology;Immunology;In Vitro;in vivo;Individual;instrument;instrumentation;Interleukin 7 Receptor;intestinal barrier;intestinal epithelium;intraepithelial;Investigation;Lymphocyte Biology;lymphocyte proliferation;Manufacturer;Mediating;member;Membrane Microdomains;Metabolic;MHC Class I Genes;MHC Class II Genes;MicroRNAs;Mucosal Immune Responses;Multiparametric Analysis;National Cancer Institute;NCI Center for Cancer Research;Outcome;Pathogenesis;Phenotype;Phosphotransferases;Post-Transcriptional Regulation;proteostasis;Provider;Reagent;receptor;receptor expression;Regulation;Regulation of Exocytosis;Regulatory T-Lymphocyte;Research Personnel;Research Project Grants;Research Support;response;Role;Signal Transduction;Signaling Molecule;single cell analysis;Specific qualifier value;stem cells;Sterility;Stimulus;T cell differentiation;T-Cell Development;T-Cell Receptor;T-Lymphocyte;TAF7 gene;Techniques;Technology;thymocyte;Thymus Gland;Tissues;trafficking;Transcription Initiation

PROJECT_TITLE: Application of Flow Cytometry to Cell Biology


NIH_SPENDING_CATS: Cancer;HIV/AIDS

PI_NAMEs: NICKLAUS, MARC  (contact)

PROJECT_TERMS: Algorithms;Anniversary;Area;Cactaceae;Catalogs;Chemical Structure;Chemicals;Collection;Computer Assisted;Computers;Data;database structure;Databases;design;Drug Design;drug development;Education;Generations;Goals;improved;Informatics;informatics tool;migration;Paper;Property;Publications;Readability;Records;Research Personnel;Resources;Running;Sampling;screening;Services;small molecule;Structure;tautomer;tool;tool development;United States National Institutes of Health;Update;Vendor;virtual;web server;web services;web site;web-based tool;Work

PROJECT_TITLE: Large Databases of Small Molecules - Drug Development Tool and Public Resource


NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;Infectious Diseases;Prevention

PROJECT_TERMS: 2019-nCoV;analog;Apoptotic;Binding Proteins;Biological Assay;CCR;Cell Death Induction;Cells;Chemistry;Clinical;cofactor;Collaborations;Computer software;conformer;Databases;design;Development;Docking;EP300 gene;Epithelial Cells;Generations;Genes;Goals;HIF1A gene;HIV-1;in silico;In Vitro;inhibitor;interest;Malignant Neoplasms;Molecular Target;N-terminal;neoplastic cell;novel;novel lead compound;novel therapeutics;Principal Investigator;programs;Property;Resources;screening;Screening for cancer;Signal Transduction;small molecule;STAT3 gene;tool;transcription factor;United States National Institutes of Health;virtual library;Work

PROJECT_TITLE: In Silico Screening for Cancer Targets