NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Genetics;Human Genome;Nanotechnology;Prevention;Women's Health Research

ORG_CITY: MILWAUKEE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: We have identified germline variants that impact breast cancer risk and therapy response through the tumor microenvironment. In this renewal application we will leverage these findings and a novel tool (Consomic Xenograft Model) for elucidating the mechanisms of increased breast cancer therapy resistance and drug delivery barriers in the tumor microenvironment.

PI_NAMEs: JOSHI, AMIT  (contact)

PROGRAM_OFFICER_NAME: DEY, SUMANA MUKHERJEE

PROJECT_TERMS: Ablation;Abraxane;Affect;Age of Onset;Albumins;angiogenesis;antibody conjugate;Award;Backcrossings;Binding;Biological Assay;Biological Models;Blood Vessels;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Model;breast cancer progression;Breast Cancer Risk Factor;Breast Cancer therapy;Breeding;cancer cell;cancer therapy;causal variant;Cell Line;Chromosome 3;Chromosome Mapping;Chromosomes;Clinical;comparative;congenic;consomic;contrast imaging;Data;density;Dependence;Disease;Disease-Free Survival;Distant;Dose;Drug Carriers;Drug Delivery Systems;Endothelium;Environment;Estrogen receptor positive;Experimental Genetics;Extravasation;Fatty acid glycerol esters;Female;Fluorescence;Formulation;Genes;Genetic;genetic manipulation;genetic variant;Germ Lines;Germ-Line Mutation;Growth;Hematogenous;Heritability;Human;Image;image guided;Imaging Device;Immunity;Immunocompetent;Immunocompromised Host;improved;in vivo evaluation;Inbred Strain;Incidence;Inherited;innovation;insight;intravital microscopy;Link;Liposomal Doxorubicin;Magnetic Resonance Imaging;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Maps;Measurable;Mediating;Modeling;Molecular;Molecular Target;Monoclonal Antibodies;Morphology;nanocarrier;nanoGold;nanomedicine;nanoparticle;nanotherapy;Neoplasm Metastasis;Neoplasms in Vascular Tissue;neoplastic cell;non-invasive imaging;Non-Malignant;Norway;notch protein;novel;Optics;overexpression;Paclitaxel;Parents;patient derived xenograft model;Perfusion;Pharmaceutical Preparations;pharmacologic;Phenotype;photothermal therapy;prognostic;prognostic indicator;Proliferating;Rat Strains;Rat Transgene;Rattus;receptor;Recovery;Reporting;Research;Resistance;response;risk variant;Role;salt sensitive;Sequence Analysis;Severe Combined Immunodeficiency;Signal Transduction;Testing;therapeutic nanoparticles;Time;Tissues;tool;Toxic effect;transcriptome sequencing;Treatment Efficacy;treatment response;triple-negative invasive breast carcinoma;tumor;Tumor Angiogenesis;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;tumor xenograft;tumorigenesis;Tumorigenicity;uptake;Variant;Vascular remodeling;vasculogenesis;whole body imaging;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Leveraging genetic mapping for personalized targeting of breast cancer microenvironment

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Estrogen;Nutrition;Obesity;Prevention;Uterine Cancer;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE This project tests two strategies to help premenopausal patients with endometrial precancer and obesity lose weight, preserve their uterus for fertility, and avoid developing cancer.

PI_NAMEs: HAGEMANN, ANDREA  (contact)

PROJECT_TERMS: Address;Aftercare;Agonist;Atypia;Atypical Endometrial Hyperplasias;bariatric surgery;Behavior Therapy;Behavioral;biomarker identification;Biopsy;Body Weight decreased;cancer prevention;Combined Modality Therapy;Development;Diagnosis;Early Diagnosis;efficacy evaluation;Endometrial;Endometrial Carcinoma;Endometrial Hyperplasia;Enrollment;Ensure;Equity;Estrogen Receptors;Estrogens;experience;FDA approved;Fertility;Funding;Future;Genetic Transcription;GLP-I receptor;Hyperplasia;Hysterectomy;Impairment;improved outcome;Injections;Institution;Insulin Resistance;insulin secretion;Intrauterine Devices;Levonorgestrel;Live Birth;Malignant Neoplasms;Measures;Metabolism;metabolomics;Obesity;Overweight;Pathology;Patients;Persons;Pharmaceutical Preparations;Placebos;Plasma;Population Sciences;predicting response;Pregnancy Rate;premalignant;Premenopause;preservation;prevent;Prevention;Primary Prevention;Progesterone;Progesterone Receptors;Progestin Therapy;Progestins;Proliferation Marker;Psychologist;Randomized;randomized, clinical trials;Randomized, Controlled Trials;recruit;Relapse;response;Route;secondary endpoint;Serum;Standardization;Telemedicine;Testing;Therapeutic;Time;Tissues;treatment as usual;Universities;Uterus;Washington;Weight;Weight Gain;weight loss intervention;Woman;women's diagnosis;Work

PROJECT_TITLE: Project 3: Primary Prevention and Uterine Preservation in Premenopausal Women with Obesity and Endometrial Hyperplasia/Cancer


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: BOSTON

ORG_DEPT: CHEMISTRY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: NARRATIVE Training young scientists and engineers in translational research in biomaterials facilitates the translation of biomaterials-based technologies to the clinic. Specifically, the Translational Research in Biomaterials (TRB) curriculum enables students to develop the creative, analytical, quantitative, and professional skills they need to make new discoveries that will revolutionize fields ranging from diagnostics and drug delivery to tissue engineering. These advances will improve patient care in multiple areas of medicine and ensure an academic and industrial workforce to meet the challenges of the 21st century.

PI_NAMEs: GRINSTAFF, MARK W. (contact);VEGAS, ARTURO

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TITLE: Translational Research in Biomaterials


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Patient Safety;Primary Health Care;Rehabilitation;Substance Misuse

ORG_CITY: PULLMAN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: PROJECT NARRATIVE Alcohol use disorder leads to a devastatingly diverse set of negative health outcomes, including significantly increased risk of hypertension, stroke, pancreatitis, liver cirrhosis, Alzheimer’s disease, multiple cancers, and multiple types of cognitive dysfunction. Theoretically framed within the Addiction Neuroclinical Assessment with hypothesized mechanisms in core domains (i.e., incentive salience, negative emotionality and cognitive function), and proceeding from a sound scientific premise we will target reduced alcohol use among alcohol use disorder patients in primary care using a carefully designed combination of contingency management (CM, or incentives in exchange for objectively verified evidence of behavior) delivered at thrice-weekly visits during the first 4-weeks of zonisamide treatment to jumpstart reductions in drinking. For the remaining 8-weeks of zonisamide, CM will be delivered at weekly visits in exchange for evidence of 100% or higher medication adherence.

PI_NAMEs: MCPHERSON, STERLING M (contact)

PROGRAM_OFFICER_NAME: FALK, DANIEL EVAN

PROJECT_TERMS: acamprosate;addiction;Address;Adherence;adherence rate;Adult;Adverse event;alcohol abuse therapy;Alcohol consumption;alcohol measurement;Alcohol Phenotype;alcohol seeking behavior;alcohol use disorder;Alcohols;Alzheimer's Disease;Animals;Anticonvulsants;Behavior;Bibliotherapy;Biochemical;biological sex;Clinical Trials;cognitive function;Community Health;contingency management;cost;Data;design;Devices;Disulfiram;Double-Blind Method;drinking;efficacy evaluation;Emotional;emotional functioning;Executive Dysfunction;experience;FDA approved;follow-up;Glucuronides;Glutamates;Goals;Health;Heavy Drinking;Heterogeneity;Human;Hypertension;Impaired cognition;improved;incentive salience;Incentives;Individual;Laboratories;Learning;Liver Cirrhosis;Malignant Neoplasms;Measures;Mediator;medication compliance;Mental Depression;Naltrexone;new technology;novel;Odds Ratio;Outcome;Pancreatitis;Participant;Patient Self-Report;Patients;Pharmaceutical Preparations;Pharmacotherapy;Placebo Control;Placebos;point of care;Population;Primary Care;primary care setting;Primary Health Care;primary outcome;prospective;Public Health;Randomized;randomized placebo-controlled clinical trial;randomized, clinical trials;recruit;reduced alcohol use;Risk;Safety;secondary outcome;Severities;Single-Blind Study;sound;standard care;Stroke;Testing;Time;Titrations;tool;treatment duration;treatment group;treatment response;two-arm trial;Urine;Visit

PROJECT_TITLE: Zonisamide for the Treatment of Alcohol Use Disorder in the Addiction Neuroclinical Assessment Framework


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Precision Medicine;Uterine Cancer;Women's Health Research

PI_NAMEs: LU, ESTHER  (contact)

PROJECT_TERMS: Adverse event;Bioinformatics;Biological Markers;Biometry;Cancer Center;career;Clinical Research;Clinical Trials;Collaborations;Computer Analysis;Consult;Core Facility;Data;Data Analyses;Data Collection;data integration;data management;data sharing;Databases;design;Development;Endometrial Carcinoma;Ensure;experience;Faculty;genomic data;Genomics;Health Sciences;Immunotherapy;medical schools;meetings;member;Minority;Monitor;New Mexico;next generation sequencing;Oklahoma;Output;personalized medicine;programs;Quality Control;Reporting;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Resources;Route;Statistical Methods;System;targeted therapy trials;Tissue Sample;Training;trial design;Universities;Visualization;Washington;Work

PROJECT_TITLE: Core 1: Biostatistics and Bioinformatics Core


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Spatially resolved single-cell transcriptomic methods promise a transformative new window into a wide array of biological questions. However, the promise of these techniques—whole-transcriptome expression profiles collected for millions of cells rapidly over large sample regions in any tissue or organism—remain practically out of reach with current implementations. Here we will develop an improved single-cell transcriptomics methodology that dramatically increases the speed, robustness, range of targeted RNAs, and breadth of organisms and tissues that can be routinely measured with such methods, transforming these techniques from bespoke methodologies to ones that can be rapidly and routinely applied broadly.

PI_NAMEs: MOFFITT, JEFFREY  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Acceleration;Adoption;Algorithms;Area;Atlases;Bar Codes;Behavior;Biological;Biomedical Research;Brain;Catalogs;Categories;cell behavior;Cell Count;Cell Culture Techniques;Cell Physiology;cell type;Cells;Clinical;Color;cost;Data Analyses;Data Collection;Data Compression;design;DNA;empowerment;Excision;Exons;Fluorescence;Fluorescence Microscopy;Fluorescent in Situ Hybridization;Formalin;Gene Expression;Genome;Image;Image Compression;imaging approach;improved;In Situ;Individual;Kinetics;Life;Location;Maps;Measurement;Measures;Methodology;Methods;microbial community;microscopic imaging;Microscopy;Modification;Molecular;molecular imaging;molecular scale;Morphology;Names;novel;novel strategies;Organism;Paraffin Embedding;Performance;Phylogenetic Analysis;Preparation;Protein Isoforms;Protocols documentation;Quality Control;Resolution;Retrieval;RNA;RNA Splicing;Role;sample fixation;Sampling;Scheme;Signal Transduction;single molecule;single-cell RNA sequencing;Speed;Stains;submicron;Synapses;Techniques;Technology;Time;Tissue Embedding;Tissue Harvesting;tissue preparation;Tissues;tool;transcriptome;transcriptomic profiling;transcriptomics;tumorigenesis;Variant

PROJECT_TITLE: Rapid, Robust, and Routine:  Multiplexed Microscopy for Spatially Resolved Whole-Transcriptomic Single-Cell Profiling and the Construction of Cell Atlases of all Tissues and in all Organisms

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Uterine Cancer;Women's Health Research

PI_NAMEs: HAGEMANN, IAN S. (contact)

PROJECT_TERMS: anti-cancer research;Award;biobank;Biostatistics Core;Blood;Cancer Center;Cancer Model;Cancer Patient;career;Catalogs;Cells;Characteristics;Clinical;Clinical Data;clinical database;Collaborations;Collection;Communities;Consent;Correlative Study;Credentialing;Data;data interoperability;data sharing;Databases;Development;Diagnosis;Disease;Eligibility Determination;Endometrial Carcinoma;Ensure;Equipment and supply inventories;Equity;Evaluation;experience;Experimental Designs;Freezing;Future;genome sequencing;Goals;Grant;Infrastructure;Institution;Institutional Review Boards;Isotopes;Leadership;Link;Liquid substance;Manuscripts;Metabolic;metabolomics;Methods;model development;New Mexico;Newly Diagnosed;Nucleic Acids;Oklahoma;operation;Organoids;Outcome;Pathology;patient derived xenograft model;Patients;Peer Review;Plasma;Preparation;preservation;prevent;Process;Prognostic Factor;programs;prospective;Protocols documentation;Publications;Qualifying;Recurrence;Research;Research Design;Research Personnel;Research Project Grants;Resources;Route;sample collection;Sampling;secondary analysis;Serum;Services;Specimen;Standardization;Structure;success;Time;Tissues;tool;Translational Research;Universities;Validation;Washington;whole genome;Work

PROJECT_TITLE: Core 2: Biospecimen, Metabolomics, and Pathology Core


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

ORG_CITY: CAMBRIDGE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Narrative: The research proposes to develop methods to fabricate magic angle spinning (MAS) NMR rotors and drive tips from single crystal diamond samples using laser micromachining techniques. The reasons for using diamond are (1) that it is stronger than other materials such as ZrO2, (2) it is transparent to microwaves and therefore better for DNP experiments, and (3) has excellent thermal conductivity so that samples will cool more efficiently. The higher strength will enable higher spinning rates and better sensitivity will lead to molecular structures with higher precision and could have a profound impact on structural biology, medical imaging and solid state NMR.

PI_NAMEs: GERSHENFELD, NEIL  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Address;Amyloid Fibrils;Area;Biological;biological systems;Bite;Chemicals;Circulation;commercialization;Compensation;Complex;complex biological systems;cost;Data;Deposition;Development;Diamond;Dimensions;Equipment;experience;experimental study;Explosion;fabrication;Failure;Frequencies;Gases;Generations;Goals;Health;Heating;Helium;Human;improved;instrumentation;Isotope Labeling;Laboratories;Lasers;Magic;manufacture;Medical Imaging;Membrane Proteins;method development;Methods;microwave electromagnetic radiation;Molecular Structure;novel;Nuclear;Nuclear Magnetic Resonance;Planet Earth;Plastics;Process;Property;Proteins;Radiation;repaired;Research;Research Personnel;Research Project Summaries;Resolution;Resources;Sampling;Signal Transduction;solid state nuclear magnetic resonance;Specific qualifier value;structural biology;Structure;System;Techniques;Technology;Temperature;Testing;Thermal Conductivity;Time;tool;vapor;zirconium oxide

PROJECT_TITLE: Diamond Rotors

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Patient Safety

ORG_CITY: LOS ANGELES

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative: Cellular proteins coordinate complex responses to stimuli, including medications, and downstream protein responses are responsible for disease-modifying effects and unintended side-effects. However, we lack an understanding of the general rules governing downstream protein responses created by medications, especially in cases where medicines bind many cellular proteins. This research aims to learn the general rules of how multi-protein stimuli influence downstream protein responses to eventually improve how medications are designed to treat disease symptoms.

PI_NAMEs: WILSON, JENNIFER LYNN (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Adverse drug event;Binding;Binding Proteins;career;Cells;Clinic;Clinical Data;Complex;Data;data integration;design;Disease;Drug Targeting;flexibility;Healthcare;improved;innovation;Learning;Link;Medicine;Mind;Modeling;network models;Outcome;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Productivity;programs;Property;protein protein interaction;Proteins;Research;Research Project Grants;response;Serious Adverse Event;side effect;Stimulus;Symptoms;Treatment Efficacy

PROJECT_TITLE: Understanding cascading cellular protein responses following multi-protein stimuli using network modeling and real-world evidence


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prevention;Uterine Cancer;Women's Health Research

PI_NAMEs: LESLIE, KIMBERLY K. (contact)

PROJECT_TERMS: Advocate;anti-cancer research;Applied Research;Basic Science;Black race;Cancer Control Research;cancer prevention;career;Clinical;Data;Dedications;Development;disability;Discipline of obstetrics;Endometrial;Endometrial Carcinoma;Ensure;Epidemiology;Faculty;Funding;Future;Goals;Grant Review;Gynecologist;Gynecology;innovation;Institution;Knowledge;Life;Malignant Neoplasms;member;Minority;Monitor;New Mexico;novel therapeutic intervention;Oklahoma;Oncologist;Outcome Assessment;Patients;Pilot Projects;Prevention strategy;Program Research Project Grants;programs;Recommendation;recruit;Request for Applications;Research;Research Personnel;Research Project Grants;Review Committee;Route;Science;Scientist;Secure;success;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;Washington;Woman;Work

PROJECT_TITLE: Developmental Research Program


ORG_CITY: CLEMSON

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: NARRATIVE Musculoskeletal disease is one of the leading causes of disability and health care expenses where an estimated 126.6 million Americans (one in two adults) are affected by a musculoskeletal condition costing an estimated $213 billion each year in treatment and lost wages. With an aging population, this figure is only set to increase and become worse since research is hampered by a low and slow rate of translation of basic discoveries into clinical practice, e.g. only 25% of highly promising biomedical discoveries resulted in a published randomized clinical trial and less than 10% were established in clinical practice within 20 years. This COBRE center implements a new concept for translational research, i.e. Virtual Human Trials, to expedite the process from concept development to new deliverable therapeutics, interventions, and devices for musculoskeletal health.

PI_NAMEs: YAO, HAI  (contact)

PROGRAM_OFFICER_NAME: NANDA, JAGPREET SINGH

PROJECT_TERMS: 3-Dimensional;Adult;Affect;aging population;American;Animal Testing;Animals;Area;arthropathies;Artificial Intelligence;authority;Award;Big Data;Bioinformatics;biomarker development;Biomedical Engineering;Biomedical Research;bioprinting;Biosensor;Bone Diseases;Cadaver;career development;Cell Nucleus;Centers of Research Excellence;Clinical;clinical practice;Clinical Research;cluster computing;Collaborations;college;commercialization;Computer Models;Computing Methodologies;Conceptions;cost;cost estimate;Development;Devices;digital;disability;Discipline;Evaluation;experience;Exposure to;Extramural Activities;fabrication;Faculty;flexibility;forging;Foundations;Funding;Generations;Goals;Grant;Growth;Health;Health Resources;Health system;Healthcare;Human;imaging modality;improved;in silico;in vivo;Infrastructure;innovation;Institution;interest;International;Intervention;Leadership;Machine Learning;manufacturing technology;member;Mentors;Microfabrication;Modeling;multi-scale modeling;multidisciplinary;Musculoskeletal;Musculoskeletal Diseases;Musculoskeletal System;new technology;novel;novel therapeutics;Outcome;Patient Care;Patients;Performance;Persons;Phase;Positioning Attribute;pre-clinical assessment;Process;Program Development;programs;Publishing;randomized, clinical trials;Recovery;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Role;Schools;Science;sensor technology;skills;Source;South Carolina;Specimen;Speed;Stretching;success;Systems Biology;Talents;Techniques;Technology;technology platform;Technology Transfer;tenure track;Testing;Therapeutic;Time;Tissue Model;Tissues;training opportunity;Translational Research;Translational trial;Translations;trend;United States National Institutes of Health;Universities;Validation;Veterinary Medicine;veterinary science;virtual human;Wages;Woman;Work

PROJECT_TITLE: SC COBRE for TranslationalResearch Improving MusculoskeletalHealth (SC-TRIMH)


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative The proportion of advanced degrees awarded to underrepresented groups in the biomedical sciences continues to be very small and does not reflect the current demographics in the US. To address this shortage, the IRACDA-UNC program provides training in research, teaching, and mentoring, along with professional development that prepares postdoctoral scholars to advance science education and inspire a full range of students, particularly those from underrepresented groups, to pursue careers in the sciences.

PI_NAMEs: LYSLE, DONALD T (contact);REISSNER, KATHRYN JOANNA

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: academic preparation;Admission activity;anti-racism;career;career development;Development;educational atmosphere;Educational Curriculum;Educational process of instructing;Environment;Equity;experience;Faculty;Fellowship Program;Grant;innovation;Institution;interest;K-Series Research Career Programs;Laboratories;Laboratory Research;Manuscripts;member;Mentors;Mentorship;Mission;North Carolina;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;Preparation;programs;Recording of previous events;Research;Research Project Grants;Research Training;Science;Scientist;skills;STEM field;student mentoring;Students;summer research;symposium;Techniques;Training;undergraduate research experience;undergraduate student;Universities;virtual;Writing

PROJECT_TITLE: Institutional Research and Academic Career Development Awards (IRACDA) - UNC Postdoctoral Fellowship Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding

PHR: NARRATIVE The mission of the ADMIN core of the South Carolina Translational Research Improving Musculoskeletal Health (SC-TRIMH) COBRE is to continue to provide sound organizational structure and a coordinated administrative framework to ensure optimum management, utilization, integration, evaluation, and oversight of this Center in its Phase II. The goal of SC-TRIMH is to enable researchers to improve muscle, bone, and joint health by implementing a concept of Virtual Human Trials (VHT) using scientific cores, collaboration, and research mentoring among others. The mission of the ADMIN Core is fostered by the Executive Committee supported by the Advisory Committee.

PROJECT_TERMS: Abbreviations;Accountability;acronyms;Advisory Committees;Animals;Award;base;Biomedical Engineering;Biomedical Research;bone;Cadaver;Centers of Research Excellence;Clinic;Clinical;Clinical Research;Collaborations;Communication;Computer Simulation;Data;design;Development;Devices;Disease;Doctor of Philosophy;Engineering;Ensure;Evaluation;experience;Extramural Activities;fabrication;Faculty;Feedback;formative assessment;Fostering;functional improvement;Funding;Glossary;Goals;Health;Health Resources;Health system;Human;Human Resources;improved;in vivo;Infrastructure;innovation;Institution;Investments;Joints;Knowledge;Leadership;Life;malformation;manufacturing technology;Medical;meetings;member;Mentors;Mission;multi-scale modeling;multidisciplinary;Muscle;Musculoskeletal;Names;Natural regeneration;novel strategies;organizational structure;Outcome;pathogen;Patient Care;Performance;Phase;Pilot Projects;pre-clinical assessment;Process;programs;Research;Research Institute;Research Personnel;Research Project Grants;Schools;Scientist;SCTR gene;Services;skills;sound;South Carolina;Teacher Professional Development;Technology;Testing;Tissues;tool;Training;Translational Research;Trauma;United States National Institutes of Health;Universities;virtual human;Work

PROJECT_TITLE: Administrative Core


PI_NAMEs: MUTCH, DAVID G (contact)

PROJECT_TERMS: anti-cancer research;Applications Grants;Cancer Etiology;career;career development;Catchment Area;Collaborations;Comprehensive Cancer Center;Dedications;Development Plans;Diagnosis;disability;Disparity;Early Diagnosis;early-career faculty;Education;Endometrial;Endometrial Carcinoma;Equity;equity, diversity, and inclusion;Extramural Activities;Faculty;Feedback;Fostering;Funding;Goals;Grant;Grant Review;Health Sciences;improved;Individual;innovation;Institution;inter-institutional;interest;Laboratories;Malignant Neoplasms;medical schools;Medicine;member;Mentors;New Mexico;novel strategies;Oklahoma;Outcome;Patient Care;peer;Peer Review;Population Sciences;Prevention;Productivity;Program Reviews;programs;Quality of life;recruit;Research;Research Design;Research Personnel;Risk;Route;Science;skills;Training;translational cancer research;Translational Research;Underrepresented Minority;Universities;Wages;Washington;Woman;Work

PROJECT_TITLE: Career Enhancement Program


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Nutrition

ORG_CITY: STANFORD

ORG_DEPT: SURGERY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative The massive loss of the small intestine results in short bowel syndrome. These patients rely on intravenous nutrition that can lead to liver failure. This research proposal will obtain the safety and efficacy data of a spring- loaded device to lengthen the intestine in a large animal model.

PI_NAMEs: DUNN, JAMES C (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Affect;Animal Model;Animals;Area;Back;Cells;Clinical;Clinical Trials;Coiled Springs;curative treatments;Data;Devices;Diameter;Dimensions;Disease;distraction;Eating;end stage liver disease;Excision;Failure;Family suidae;functional improvement;Goals;Growth;Health;Health Care Costs;improved;innovation;Intestinal Obstruction;Intestinal Perforation;Intestines;Intravenous;jejunum;Length;Liver Failure;Malabsorption Syndromes;Measures;mechanical device;Mechanics;Mediating;Modeling;nitinol;novel;nutrition;Operative Surgical Procedures;Parenteral Nutrition;Patients;Phase I Clinical Trials;porcine model;Positioning Attribute;preclinical study;Rattus;Research;Research Proposals;Residual state;Rodent;Rodent Model;Safety;scale up;Short Bowel Syndrome;Small Intestines;Supportive care;Surface;Surgical sutures;Techniques;treatment strategy;United States;Weaning;Work

PROJECT_TITLE: Spring Mediated Enterogenesis

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Genetics;Human Genome;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

ORG_STATE: NY

PHR: Major depressive disorder (MDD) is a common disease with high risk of suicide, great social and economic costs, and poor treatment response, where smaller hippocampus, with loss of neurons and astrocytes, have been reported, as well as gene variants potentially implicated in brain function. This project will identify differentially expressed proteins and genes between MDD and non-psychiatric control hippocampus cell clusters, at a regional and single cell level, together with spatial co-mapping of RNA, epigenetic (Assay for Transposase-Accessible Chromatin, ATAC) and protein changes (using DBiT-seq and Visium), and determination of cell fate trajectories based on RNA splicing profiles (RNA velocity). Identified molecular regulators of hippocampus cell viability and function will provide potential druggable targets for new MDD treatments, to be later tested in cellular and animal models.

PI_NAMEs: BOLDRINI, MAURA  (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA JOY

PROJECT_TERMS: Adult;adult neurogenesis;Age;allostatic load;Amygdaloid structure;Anatomy;Animal Model;anti-depressive agents;Apoptosis;Astrocytes;ATAC-seq;Atlases;Autopsy;Bar Codes;Biological Assay;biomarker identification;Brain;Brain Diseases;Cell Adhesion;Cell Cycle Inhibition;cell determination;Cell Lineage;Cell model;Cell Nucleus;Cell Physiology;Cell Survival;Cells;Chromatin;cognitive function;Complex;Custom;Cytoplasmic Granules;Data;Decision Making;dentate gyrus;depressive symptoms;differential expression;Disease;DNA Repair;early life adversity;economic cost;Emotional;emotional functioning;Epigenetic Process;epigenomics;excitatory neuron;Female;Functional disorder;Gene Expression Regulation;Genes;genetic variant;genome wide association study;Genomics;Glucocorticoid Receptor;granule cell;Heterogeneity;high risk;hippocampal pyramidal neuron;Hippocampus;Human;Hydrocortisone;Immunity;Inflammation;inhibitory neuron;Life;life span;Link;Major Depressive Disorder;male;Maps;Mass Spectrum Analysis;Memory;Messenger RNA;Meta-Analysis;Microglia;Mitosis;Molecular;mood regulation;mRNA Expression;multiple omics;Mus;Neurites;neurogenesis;Neuroglia;neuron loss;Neuronal Plasticity;Neurons;neuropsychiatry;new technology;new therapeutic target;Ontology;Pathogenesis;Pathogenicity;Patients;Phenotype;Pilot Projects;Predisposition;Prefrontal Cortex;prevent;progenitor;Proliferating;Proteins;Proteomics;Published Database;Publishing;Reporting;Resolution;response;Rewards;RNA;RNA Splicing;Rodent;Sampling;Severities;single nucleus RNA-sequencing;Slide;Small Nuclear RNA;social;stem cell proliferation;Stress;Sudden Death;suicidal risk;synaptogenesis;Technology;Testing;Tissues;Toxicology;transcription factor;transcriptomics;Transposase;treatment response;Uniport;Variant;Woman;XCL1 gene

PROJECT_TITLE: Human brain multi-omics to decipher major depression pathophysiology

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PHR: NARRATIVE The Multi-scale Computational Modeling (MCM) Core will continue to provide support for SC-TRIMH investigators toward building a patient-specific and precision-care musculoskeletal system through computer simulations at molecular, cellular, tissue, body, and population levels, with a new addition of Artificial Intelligence/Machine Learning (AI/ML) capacities for big data driven modeling in the COBRE Phase II. This core will take full advantage of the current resources and capabilities at Clemson University, which entails Clemson's powerful supercomputing capability, known as the “Palmetto Cluster” (listed on the TOP500 in the world), the well-established Multiphysics Modeling Studio, the extensive AI research capacity at Clemson, and the large amounts of patient-specific data available for model building at the PRISMA Health System.

PROJECT_TERMS: Adopted;Algorithms;Area;Artificial Intelligence;artificial intelligence algorithm;Big Data;Biomedical Engineering;Centers of Research Excellence;cluster computing;Code;cohort;Communities;Complex;Computer Models;Computer Simulation;Computer software;computerized tools;Coupled;Data;data exchange;data-driven model;Development;Devices;diagnostic strategy;Differential Equation;Discipline;Educational workshop;Ensure;experience;Finite Element Analysis;Health;Health system;Human body;improved;Infrastructure;Intervention;Laws;Machine Learning;machine learning model;Mentors;Methods;Mission;model building;Modeling;Molecular;molecular dynamics;multi-scale modeling;multidisciplinary;Musculoskeletal;Musculoskeletal System;novel diagnostics;Outcome;parallel computer;Patients;personalized care;Phase;Physics;Population;Research;Research Personnel;Research Project Grants;Resources;Running;simulation;Software Tools;South Carolina;Specimen;Statistical Models;Strategic Planning;Supercomputing;Therapeutic;Thermodynamics;Tissues;tool;Training;treatment strategy;Universities;virtual human

PROJECT_TITLE: Multi-Scale Computational Modeling Core (MCM)


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Rheumatoid Arthritis

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Rheumatoid arthritis (RA) is a disease that affects the joints that is characterized by immune dysregulation resulting in chronic inflammation that damages cartilage and bone and can lead to permanent joint damage and disability. We are studying how the fibroblast tissue cells in the joint regulate inflammation and drive joint damage in RA. We are determining what drives the abnormal cells in order to find new ways to target treatments for RA.

PI_NAMEs: BRENNER, MICHAEL B. (contact);RAYCHAUDHURI, SOUMYA

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Abnormal Cell;Acceleration;Affect;Anatomy;Automobile Driving;B-Lymphocytes;Blood Vessels;bone;Cartilage;cell type;Cells;Characteristics;chemokine;Chronic;chronic inflammatory disease;comparison control;cytokine;Cytokine Activation;Data;Degenerative polyarthritis;Development;disability;Discriminant Analysis;Disease;Endothelium;experimental study;Fibroblasts;Fibrosis;Flow Cytometry;Gene Expression;Genetic Transcription;HLA-DR Antigens;Human;Image;Immune;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Arthritis;insight;Interferon Type II;Interferons;Interleukin-1 beta;Interleukin-6;joint injury;Joints;Knowledge;leukocyte activation;Leukocytes;Ligands;Location;lymph nodes;Lymphoid Tissue;Macrophage;Medicine;mouse model;notch protein;NOTCH3 gene;novel strategies;Organ;Organoids;Pathology;Pattern;Peripheral;Phenotype;Play;Population;prevent;Production;receptor;recruit;Rheumatoid Arthritis;Role;Signal Transduction;single-cell RNA sequencing;Synovial Membrane;Synovitis;System;Systemic Lupus Erythematosus;T-Lymphocyte;targeted treatment;Testing;Tissues;TNF gene;transcriptome sequencing;transcriptomics

PROJECT_TITLE: Expanded fibroblast subset drives pathology in rheumatoid arthritis

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


PHR: NARRATIVE The Advanced Fabrication and Testing (AFT) Core will continue to be the innovation engine of the SC-TRIMH program by providing essential engineering and technological support and mentoring for the TRIMH investigators to succeed in their projects. As the centralized resource in engineering (electrical, optical, mechanical, and materials) designs, rapid prototyping, sensors and instrumentation, and advanced testing, the AFT Core will bring the latest tools and technology innovations to the minds and hands of the biomedical researchers, and become a leading, centralized, and sustainable engineering resource for translational musculoskeletal health research at Clemson University, South Carolina, and beyond.

PI_NAMEs: XIAO, HAI  (contact)

PROJECT_TERMS: 3-Dimensional;3D Print;Applications Grants;Area;Automation;Award;Biocompatible Materials;Biological;Biomedical Engineering;Centers of Research Excellence;Ceramics;Client;Clinical;Complex;data acquisition;design;Diagnosis;Discipline;Engineering;engineering design;Equipment;Event;experience;fabrication;Funding;Generations;Glass;Goals;Grant;graphical user interface;Hand;Harvest;Health;human model;Image;Imaging technology;improved;In Situ;Industrialization;innovation;instrument;instrumentation;Lasers;Light;manufacture;manufacturing systems;Measurement;Mechanics;meetings;member;Mentors;Metals;Mind;models and simulation;Molecular;multidisciplinary;Musculoskeletal;Musculoskeletal Diseases;operation;Optics;Patients;Phase;Physical environment;Pilot Projects;Procedures;Process;Program Sustainability;programs;prototype;Publications;Research;Research Personnel;Research Project Grants;Research Proposals;Research Support;Resources;second harmonic;Secure;sensor;Services;signal processing;Source;South Carolina;Standardization;Strategic Planning;success;System;technological innovation;Technology;Testing;Time;Tissues;tool;Training;Training Activity;Translating;Translations;United States National Institutes of Health;Universities;Validation;virtual human;Work

PROJECT_TITLE: Advanced Fabrication and Testing Core (AFT)


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Contraception/Reproduction;Pain Research;Patient Safety;Women's Health Research

ORG_CITY: CLEVELAND

ORG_DEPT: UROLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The goal of this study is to not only identify which surgery for treatment of uterovaginal prolapse is objectively better, but how to best identify the correct procedure for each individual patient. This study will merge traditional surgical research trial design with qualitative research methodology, to gain a deep understanding of what is most important to a woman when she is deciding on a treatment option and how it relates to her perception of recovery after surgery and long-term treatment success. We hope that this study will also create an individualized approach for surgical treatment of pelvic organ prolapse.

PI_NAMEs: HIJAZ, ADONIS K (contact)

PROGRAM_OFFICER_NAME: DEYAMPERT, TARA LYNN

PROJECT_TERMS: Abdomen;Accounting;Address;Affect;Aftercare;American;Apical;Atopobium vaginae;Bladder;Body Image;Calibration;Caregivers;Caring;Clinical Trials;Clinical Trials Design;comparative;Comparative Study;Data;Decision Making;Defect;Diagnosis;Dimensions;Effectiveness;effectiveness evaluation;expectation;experience;Failure;Fatigue;Goals;hymen;Hysterectomy;improved;individual patient;Institution;Intervention;Interview;Intestines;Knowledge;Lead;lifetime risk;Ligaments;Literature;Litigation;Measures;Methods;minimally invasive;Modality;Morbidity - disease rate;Nausea;Observational Study;Operative Surgical Procedures;Opioid Analgesics;Outcome;pain score;patient expectation;patient oriented;Patient Outcomes Assessments;patient safety;Patient-Focused Outcomes;Patients;Pelvic Floor Disorders;pelvic organ prolapse;Pelvis;Perception;Perioperative;Perioperative Care;personalized approach;Persons;Pessaries;Postoperative Complications;Postoperative Pain;Postoperative Period;postoperative recovery;preference;Probability;Procedures;Professional Organizations;Ptosis;Qualitative Research;Quality of life;Questionnaires;Randomized;randomized, clinical trials;Recovery;repaired;Reporting;Research;Research Methodology;Retreatment;Selection for Treatments;Seminal;Series;Severities;Sex Functioning;shared decision making;social stigma;Societies;success;Surgeon;surgery outcome;surgical research;Surgical Specialties;Suspensions;symptom treatment;Symptoms;Time;tissue repair;trial comparing;trial design;United States;Vagina;Vaginal Hysterectomy;Vaginal Prolapses;Voice;Woman;women's clinical trial;Work

PROJECT_TITLE: Patient-Centered Outcomes of Sacrocolpopexy versus Uterosacral Ligament Suspension for the Treatment of Uterovaginal Prolapse

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Hepatitis;Liver Disease;Substance Misuse

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Alcohol associated liver disease (ALD) caused by chronic alcohol abuse is a major health problem with high economic burden and limited treatment options. Our previous studies have established a pathogenic role for proteostasis mediator HSP90 in ALD. This R01 renewal resubmission application proposes investigation of epigenetic and metabolic pathways in macrophage activation. We will extend our analysis to assessment of HSP90 and metabolic genes in monocytes of alcoholic hepatitis patients. These studies will provide novel mechanisms and extend our horizons to identify new therapeutic avenues for ALD.

PI_NAMEs: MANDREKAR, PRANOTI  (contact)

PROGRAM_OFFICER_NAME: PERRUCCIO, ELIZABETH M

PROJECT_TERMS: Acetylation;activating transcription factor 3;aerobic glycolysis;Affect;Alcohol abuse;Alcohol consumption;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Bioenergetics;Cell Nucleus;Cellular Stress;Chromatin;Chronic;Cirrhosis;clinical development;Cytoplasm;Data;disease model;Economic Burden;Endoplasmic Reticulum;endoplasmic reticulum stress;Endothelial Cells;Enzymes;Epigenetic Process;Ethanol;extracellular vesicles;Fatty Liver;Funding;Future;Gene Expression;Genes;Glucose Transporter;Glycolysis;GRP78 gene;Health;Heat-Shock Proteins 90;Hepatocyte;Hexokinase 2;HIF1A gene;HSF1;HSP 90 inhibition;Human;immune activation;In Vitro;in vivo;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Interleukin-1 beta;Investigation;Kupffer Cells;lipid metabolism;Liver;Liver diseases;liver inflammation;liver injury;Macrophage;Macrophage Activation;Malignant Neoplasms;Mediating;Mediator;Messenger RNA;Metabolic;Metabolic Pathway;Metabolism;Molecular Chaperones;monocyte;Mus;Myelogenous;nanoparticle;novel;novel therapeutics;paralogous gene;Pathogenicity;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;prevent;Primary carcinoma of the liver cells;Protein Isoforms;Proteins;Proteome;proteostasis;receptor;Reporting;Resolution;Role;Signal Transduction;Signaling Molecule;SLC2A1 gene;Steatohepatitis;Stress;therapeutic target;tissue injury;TLR4 gene;TREM2 gene

PROJECT_TITLE: Heat shock protein 90 in alcoholic liver disease: targeting macrophage Function

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


PHR: NARRATIVE The Pre-Clinical Assessment Core (PAC) will continue to provide expertise and skills for SC-TRIMH investigators to further evaluate the potential of their technologies, diagnostic methods, or treatments for the advancement of patient care. PAC uses donated human cadavers and live animals to test devices or new treatments for bone and joint diseases. Phase II PAC offers expanded facilities and integrated capabilities for assessment of innovative musculoskeletal technology, which is an important step to assure the safety and effectiveness of any devices or treatments before they can be used in the clinics.

PI_NAMEs: JONES, JERYL  (contact)

PROJECT_TERMS: Accreditation;Address;Anatomy;animal care;animal imaging;Animal Model;Animals;arthropathies;Attention;Autopsy;Awareness;bench to bedside;Biochemistry;Biological Markers;Biomedical Engineering;Biomedical Research;Bone Diseases;Budgets;Cadaver;Caring;Center for Translational Science Activities;Centers of Research Excellence;Charge;Clinic;Clinical;clinical practice;clinically relevant;Collaborations;Computer Models;Consultations;Core Facility;Development;Devices;Diagnostic Procedure;diagnostic strategy;Effectiveness;Evaluation;Experimental Designs;experimental study;Farm;flexibility;Foundations;Future;Goals;Harvest;Health;Health system;histotechnology;Human;Human Resources;human tissue;Image Analysis;imaging facilities;Implant;implantation;improved;In Vitro;in vivo;innovation;invention;Laboratories;Leadership;Location;Logistics;Medicine;Mentors;Methodology;Methods;Mission;model design;Modeling;Musculoskeletal;new technology;novel;Operative Surgical Procedures;Optics;Orthopedics;Patient Care;Patients;Phase;Physical therapy;pre-clinical assessment;Pre-Clinical Model;pre-clinical research;preservation;Process;programs;Protocols documentation;Research;Research Design;Research Personnel;Resources;Role;Safety;Sampling Studies;Scientist;Service animal;service organization;Services;skills;South Carolina;Speed;Sports Medicine;stem cells;Strategic Planning;Support Groups;Surgeon;Technology;technology development;Testing;Tissue Procurements;Tissue Sample;Training;Training Programs;Translational Research;Travel;Universities;virtual human

PROJECT_TITLE: Preclinical Assessment Core (PAC)


ORG_CITY: Princeton

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Understanding how tissues are assembled and organized into complex three dimensional arrangements is a central challenge in the fields of tissue engineering and regenerative medicine. The collective polarization and alignment of cells across a tissue is a phenomenon known as planar cell polarity (PCP) that is conspicuously lacking in vitro organs, yet is absolutely essential for proper organ formation and function. Ultimately, deciphering the mechanisms that establish PCP will help us to understand how misregulation of this pathway causes developmental defects, and bring us closer to developing fully functional organs in vitro.

PI_NAMEs: DEVENPORT, DANELLE N (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: 3-Dimensional;Adhesives;Anisotropy;Architecture;Binding;Biochemical;Biological;Biological Assay;Biological Models;Biophysics;Cadherins;Cell Aggregation;cell assembly;cell behavior;Cell Communication;cell motility;Cell Separation;Cells;Characteristics;Cilia;ciliopathy;Complex;Congenital Abnormality;Congenital Heart Defects;Cues;Cultured Cells;deafness;Defect;Development;Embryo;Embryonic Development;Epidermis;Epithelial Cells;Epithelium;Event;Feedback;Goals;Hair follicle structure;Human;Hydrocephalus;Image;Imaging Techniques;In Vitro;innovation;insight;Intercellular Junctions;keratinocyte;Laboratories;Length;Maps;mechanical signal;Mediating;Membrane;Methods;Modeling;Molecular;molecular scale;Monitor;Mus;nanoscale;Neural Tube Closure;Organ;Organism;Organoids;Pathway interactions;Pattern;planar cell polarity;Positioning Attribute;Protein Dynamics;Proteins;reconstitution;Regenerative Medicine;regenerative tissue;Role;self assembly;self organization;Skin;skin organogenesis;Sorting;stem cells;Structure;superresolution imaging;System;technology development;Tissue Engineering;Tissues;Work

PROJECT_TITLE: Multiscale coordination of planar cell polarity

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Clinical Research;Lung;Patient Safety;Pulmonary Hypertension

ORG_CITY: AUSTIN

ORG_NAME: BRIDGESOURCE MEDICAL CORPORATION

ORG_STATE: TX

PHR: Project Narrative Respiratory disorders affect over 10% of the US population and can be better managed using an aerosol delivery device that does not depend on specific breathing patterns that are difficult to execute, especially by elderly patients. Such a device can be used to optimize administration, and positively effect compliance in pulmonary hypertension, improving outcomes.

PI_NAMEs: PORTERFIELD, JOHN E (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Academic Medical Centers;aerosolized;Aerosols;Affect;Air Movements;Area;Arteries;Back;Blood capillaries;Breathing;Cessation of life;Clinical;Clinical Research;commercialization;Consult;Custom;Deposition;design verification;Development;Device Designs;Devices;Diagnosis;Disease;Disease Management;Dose;Drug Delivery Systems;Drug Formulations;effective therapy;Equilibrium;Exhalation;experience;expiration;Formulation;Goals;Heart;Heart failure;Hour;Housing;hypertension treatment;Iloprost;improved;improved outcome;Inhalation;Inhalation Therapy;Interstitial Lung Diseases;invention;Lead;Leadership;Left;Life;Life Expectancy;Lung;Lung Diseases;mechanical force;Medial;Medical;medication administration;meter;miniaturize;Nebulizer;novel;older patient;Oral;particle;Particle Size;Pathway interactions;Patient Compliance;Patient Monitoring;Patients;Pattern;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacotherapy;Pharyngeal structure;Phase;Physician Executives;Population;Population Sizes;Positioning Attribute;pressure;Principal Investigator;Prognosis;Prostaglandins;pulmonary arterial hypertension;Pulmonary Hypertension;Radial;Research;Respiration;Respiration Disorders;respiratory;Respiratory Therapy;sensor;side effect;Small Business Innovation Research Grant;Speed;Spottings;System;Techniques;Testing;Texas;therapeutic target;Time;tool;United States Food and Drug Administration;Universities;wasting

PROJECT_TITLE: Novel Device to Optimize Aerosol Drug Delivery for Pulmonary Hypertension Treatment


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Estrogen;Genetics;Pediatric;Women's Health Research

PHR: NARRATIVE Differences between males and females is termed sexual dimorphism and causes significant variation in the craniofacial skeleton. These changes between sexes produce functional changes in mandible movement, common conditions that require surgical correction, and distinct prevalence and progression of several diseases. This proposal will directly address how sex generates variation in the shape of the craniofacial skeleton, including developmental origins, genetic risk factors, and the influence of hormones.

PI_NAMEs: POWDER, KARA E (contact)

PROJECT_TERMS: Address;Adult;Affect;Animals;Bioinformatics;Biological;Biology;Bite;bone;Bone Density;Bone Development;Candidate Disease Gene;candidate identification;cell type;Cells;Centers of Research Excellence;Chemicals;Chickens;Cichlids;Cleft lip with or without cleft palate;craniofacial;craniofacial development;cranium;Data;Degenerative polyarthritis;Development;Disease;Embryo;Embryonic Development;Environment;Estradiol;fabrication;Face;Female;Fishes;Foundations;Future;Genes;Genetic;genetic analysis;Genetic Polymorphism;genetic risk factor;Genomics;Gonadal Steroid Hormones;Grant;Health;hormonal signals;Hormones;Human;human model;Immersion;improved;innovation;insight;Jaw;kinematics;Knowledge;Libido;male;Mandible;Mechanics;Medical;men;Mentorship;microCT;model organism;Modeling;Molecular;Morphology;Movement;multi-scale modeling;Mus;Musculoskeletal;Musculoskeletal System;novel therapeutics;Operative Surgical Procedures;optical imaging;orofacial cleft;Outcome;Paper;Patients;Pattern;Phase;Phenotype;Physiologic Ossification;pre-clinical assessment;Prevalence;Progesterone;Property;Publishing;Research Project Grants;Risk Factors;Role;Series;Severities;sex;sex as a biological variable;sexual dimorphism;shape analysis;Shapes;Signal Transduction;Skeleton;symposium;synergism;System;Temporomandibular Joint Dysfunction Syndrome;Testing;Time;transcriptome sequencing;Universities;Variant;Vertebrates;Woman;Work;X-Ray Computed Tomography

PROJECT_TITLE: Origins of Sexual Dimorphism in the Craniofacial Skeleton


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Physical Injury - Accidents and Adverse Effects;Prevention;Tobacco;Tobacco Smoke and Health

PHR: NARRATIVE Rotator cuff tendon tears account for more than 4.5 million physician visits annually, and multiple risk factors can lead to pre-existing degenerations, putting an estimated 17 million Americans at increased risk for rotator cuff impairment and tearing. This proposal aims to understand how cigarette smoking, an important yet complicated risk factor for rotator cuff injuries, influences the structures within the tendon-bone interface and their biomechanics. A computational modeling framework will be developed to more fully understand the mechanisms of the degenerative effects of smoking on the rotator cuff tendon-bone interface and as a foundation for future work on developing better therapeutics and surgical approaches for repairing the interface.

PI_NAMEs: MENG, ZHAOXU  (contact)

PROJECT_TERMS: Adopted;Adult;Adverse effects;Affect;American;Animal Model;Animals;Architecture;Behavior;Biochemical;bioimaging;Biomechanics;bone;Bone Tissue;Cadaver;calcification;Calcium;Centers of Research Excellence;Cigarette;cigarette smoke;cigarette smoking;Collagen;Collagen Fiber;Complex;computer framework;Computer Models;Control Groups;Coupled;crosslink;Custom;Data;Dependence;Deterioration;Diameter;Distal;Elements;Environment;Failure;Fiber;Fluorescence;Foundations;Future;Generations;Goals;Grain;healing;high risk;high school;Histologic;Human;humerus;Image;Impairment;improved;In Situ;innovation;insight;interest;Knowledge;Laws;Length;Measurement;mechanical properties;Mechanics;Methods;Microscopic;microscopic imaging;Minerals;Modeling;Modulus;molecular dynamics;molecular scale;Morphology;multi-scale modeling;Musculoskeletal System;Nicotine;novel;Operative Surgical Procedures;Osmosis;Patients;Pattern;Phase;Physicians;Pump;Rattus;repair strategy;repaired;Reporting;Research;Risk;Risk Factors;Role;Rotator Cuff;rotator cuff injury;rural area;sample fixation;second harmonic;Smoke;Smoking;soft tissue;South Carolina;Structure;Structure-Activity Relationship;supraspinatus muscle;surgery outcome;Techniques;Tendon structure;Testing;Therapeutic;Tissues;tool;Tracer;treatment strategy;two-photon;Validation;Visit;Work;Youth

PROJECT_TITLE: Effects of Smoking on the Rotator Cuff Tendon-Bone Enthesis


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Lung;Mental Health;Neurosciences;Patient Safety;Pediatric;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Ventilated pediatric patients are frequently over-sedated and the majority suffer from delirium, a form of acute brain dysfunction that is an independent predictor of increased risk of dying, length of stay, and costs. Universally prescribed sedative medications—the GABA-ergic benzodiazepines—worsen this brain organ dysfunction and independently prolong duration of ventilation and ICU stay, and the available alternative sedation regimen using dexmedetomidine, an alpha-2 agonist, has been shown to be superior to benzodiazepines in adults, and may mechanistically impact outcomes through positive effects on innate immunity, bacterial clearance, apoptosis, cognition and delirium. The mini-MENDS trial will compare dexmedetomidine and midazolam, and determine the best sedative medication to reduce delirium and improve duration of ventilation, and functional, psychiatric, and cognitive recovery in our most vulnerable patients— survivors of pediatric critical illness.

PI_NAMEs: PANDHARIPANDE, PRATIK ;SMITH, HEIDI A B (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Acute;Admission activity;Adult;Age;aged;alpha 2 agonist;Anesthetics;Anti-Inflammatory Agents;Antioxidants;Apoptosis;Behavioral;Benzodiazepines;Biological Markers;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Brain;brain dysfunction;Cessation of life;Characteristics;Child;Childhood;Clinical;Cognition;Cognitive;cognitive development;cognitive recovery;Coma;Communication;Complement;confusion assessment method;Conscious;cost;Critical Care;Critical Illness;cytokine;Data;Delirium;Developmental Delay Disorders;Dexmedetomidine;E-Selectin;endothelial dysfunction;Endothelium;Enrollment;epidemiology study;Exposure to;Failure;Functional disorder;functional status;GABA Agents;GABA Agonists;Goals;Guidelines;Hospital Costs;Iatrogenesis;Impaired cognition;improved;improved outcome;Incidence;Infant;infection rate;Inflammation;Inflammatory;Infusion procedures;Injury;Interleukin-1 beta;Interleukin-10;Interleukin-6;Length;Length of Stay;Link;Mechanical ventilation;Mediating;Mediation;Medicine;Memory;Mental Health;Midazolam;Modeling;Morbidity - disease rate;mortality;Myocardial;Natural Immunity;Neurocognitive;Neurologic Dysfunctions;neuropsychiatry;Nursery Schools;Organ;Outcome;Patient-Focused Outcomes;Patients;Pediatric Intensive Care Units;pediatric patients;Persons;Pharmaceutical Preparations;Phase;Plasminogen Activator Inhibitor 1;Post-Traumatic Stress Disorders;post-traumatic symptoms;Predictive Value;Prevalence;Problem Solving;Procedures;Propofol;Protocols documentation;Psychiatrist;Publishing;Randomized;Recommendation;Recovery;reduce symptoms;Regimen;Reporting;respiratory;Risk;Role;Screening procedure;Sedation procedure;sedative;Severity of illness;Societies;Specificity;Survivors;Syndrome;Testing;TNF gene;Toddler;tool;Validation;ventilation

PROJECT_TITLE: Maximizing Efficacy of Goal-Directed Sedation to Reduce Neurological Dysfunction in Mechanically Ventilated Infants and Children Study (mini-MENDS)

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(JA)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Emergency Care;Hematology;Rare Diseases

ORG_CITY: DANBURY

ORG_NAME: PEROSPHERE TECHNOLOGIES INC.

ORG_STATE: CT

PHR: Project Narrative Work under this proposal supports development and commercialization of a broad-spectrum coagulometer based on novel technology that promises to enable rapid and precise measurements of the effects of anticoagulants, their reversal agents and thrombolytic drugs on blood clotting and clot lysis processes, respectively, directly at the point-of-care. Initial marketing efforts will focus on use of the coagulometer for monitoring of the direct oral anticoagulants (DOACs) and low molecular weight heparins (LMWHs) with a Clotting Time assay. The proposed research will yield clinical clotting time reference ranges for the DOACs, in direct support of initial, future marketing goals, and assessment of the device’s ability to detect and measure inherited or acquired coagulopathies as well as to monitor effects of the novel factor XI/XIa inhibitor abelacimab, in support of future device applications.

PI_NAMEs: BAKHRU, SASHA H (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Accident and Emergency department;Activated Partial Thromboplastin Time measurement;Address;Anti-phospholipid Syndrome;Anticoagulants;Anticoagulation;Biological Assay;biomarker development;Blood;Blood coagulation;Blood Coagulation Disorders;Blood Platelets;Blood specimen;Caring;Citrates;Classification;Clinic;Clinical;clinical development;Clinical Trials;Coagulation Process;commercialization;Cytolysis;Detection;Development;Devices;Diagnostic;Disease;Documentation;Dose;Emergency Situation;Emergency treatment;Event;F8 gene;Factor V;Factor XI;Fibrin;Fibrinolytic Agents;Functional disorder;fundamental research;Future;Gene Mutation;gene therapy;Glass;Goals;Health Care Costs;Health Professional;healthy volunteer;Hemophilia A;Hemorrhage;Hospitals;Hyperhomocysteinemia;improved;Inherited;inhibitor;Inpatients;Label;Light;Liver diseases;Low-Molecular-Weight Heparin;Manuals;Marketing;Measurement;Measures;Medical;Medical Device;Methods;Microfluidics;Monitor;new technology;Normal Range;novel;Operative Surgical Procedures;Oral;Outcome;Outpatients;Pathway interactions;Patient Care;patient screening;Patients;Pharmaceutical Preparations;Pharmacy facility;Phase III Clinical Trials;Physicians;Plasma;point of care;Point of Care Technology;potential biomarker;Process;Protein C Deficiency;Protein S Deficiency;Prothrombin;Recombinants;Reference Values;Research;response;restoration;Risk;routine care;Sales;Sampling;Schedule;Scheme;Silicon;Surface;Surrogate Endpoint;Technology;temporal measurement;Testing;Therapeutic;Thrombin;Time;transmission process;Venous;Vitamin K Deficiency;volunteer;von Willebrand Disease;Whole Blood;Work

PROJECT_TITLE: Novel Broad-Spectrum Point-of-Care Coagulometer


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: NARRATIVE Neovascular age-related macular degeneration is a leading cause of vision loss and blindness. A challenging subtype of this disease develops chorioretinal anastomoses, vascular lesions which unfortunately can be resistant to treatment. Our research aims to understand the developmental and molecular mechanisms driving these lesions to help guide new therapies.

PI_NAMEs: KIM, TYSON NAM (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Adult;Age related macular degeneration;Anastomosis - action;angiogenesis;Animal Model;Arteries;Atrophic;Attention;Automobile Driving;Blindness;Blood capillaries;Blood flow;Blood Vessels;candidate identification;career development;Cells;Choroid;choroidal circulation;Chronic;Classification;Collagen Type IV;Communities;Data Set;Development;Disease;disorder subtype;Elderly;Endothelial Cells;Endothelium;Exudate;Exudative age-related macular degeneration;Eye;Fibrosis;Gene Expression;Genes;Goals;Hemorrhage;High Prevalence;Histologic;Hot Spot;human disease;Image;innovation;insight;Interdisciplinary Study;intravital imaging;Lesion;Mentorship;Modeling;Modernization;Molecular;mouse model;multiphoton imaging;multiphoton microscopy;Mus;Mutant Strains Mice;Mutation;neovascularization;Newly Diagnosed;novel;novel strategies;novel therapeutics;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pattern;Physiologic arteriovenous anastomosis;Population;Prognosis;Protocols documentation;Recurrence;Refractory;Research;Research Personnel;Research Project Grants;Research Proposals;resilience;Resistance;Resolution;Retina;retina circulation;Retinal Detachment;RNA;Role;Sclera;serial imaging;Serous;Shunt Device;single-cell RNA sequencing;skills;spatiotemporal;Specific qualifier value;Specificity;Specimen;Structure of retinal pigment epithelium;Testing;Therapeutic;three photon microscopy;Tissues;transcriptomics;Vascular Diseases;Vascular Endothelial Growth Factors;Vascular Proliferation;Veins;Venous;vision science;Visual;Work

PROJECT_TITLE: Elucidating the developmental and molecular mechanism of chorioretinal anastomoses in a model of type 3 neovascular age-related macular degeneration


NIH_SPENDING_CATS: Arthritis;Building Research Capacity at Institutions with Limited NIH Funding;Organ Transplantation;Osteoarthritis;Transplantation

PHR: NARRATIVE Meniscal allograft transplantation (MAT), a medically necessary treatment for patients with symptomatic meniscal loss, has been restricted by the donor-recipient size-matching challenge resulting from ineffective preservation of donor fresh allografts. We propose to overcome the limitations of MAT by developing an ice- free cryopreservation method incorporating special warming technology to preserve cell viability, tissue structure, and biomechanical properties in meniscal allografts during long term storage. This research will lay the foundation for more efficient preservation of various meniscal grafts including human meniscal allografts, tissue-engineered grafts, and xenografts for future treatment of meniscal injuries.

PI_NAMEs: WANG, SHANGPING  (contact)

PROJECT_TERMS: 3-Dimensional;Address;Allografting;American;amorphous solid;Anatomy;Animal Behavior;Animals;animation;Architecture;articular cartilage;Biochemical;Biomechanics;Blood Vessels;Cadaver;Cell Survival;Cells;Centers of Research Excellence;Clinical;Collaborations;Collagen;Complex;Computer Models;Contralateral;cryogenics;Cryopreservation;Crystal Formation;Data;Degenerative polyarthritis;Dependence;Development;Diffusion;effusion;Elements;Equilibrium;Excision;Extracellular Matrix;Family suidae;Foundations;Freezing;Future;Goals;Heating;Heterogeneity;Human;Ice;improved;In Vitro;in vivo;Infiltration;Knee;Knee Injuries;Knee Osteoarthritis;Knowledge;Location;Logistics;Medial meniscus structure;medically necessary care;meniscal tear;meniscus injury;Meniscus structure of joint;Methodology;Methods;Modeling;Morphology;nanowarming;Nature;novel strategies;Operative Surgical Procedures;Outcome;Outcomes Research;Pain;Patients;Penetration;Phase;Pilot Projects;Poison;porcine model;Postoperative Period;pre-clinical;preservation;Preservation Technique;prevent;Process;Property;Protocols documentation;Refrigeration;Replacement Arthroplasty;Research;Research Personnel;Sampling;screening;Spectroscopy, Fourier Transform Infrared;standard of care;Structure;Suspensions;symptom treatment;Technology;Temperature;Testing;Therapeutic;Time;Tissue Banks;Tissue Donors;Tissue Engineering;Tissues;Toxic effect;Transplantation;United States;Validation;Work;Xenograft procedure

PROJECT_TITLE: Ice-free Cryopreservation with Nanowarming for Banking of Viable Meniscal Transplants


NIH_SPENDING_CATS: Anxiety Disorders;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Neurosciences;Opioids;Serious Mental Illness

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Obsessive-compulsive disorder (OCD) often responds inadequately to serotonin reuptake inhibitors (SRIs). Given the morbidity and dysfunction OCD imposes on millions of U.S. adults, exploring whether SRI non- responders are helped by adding drugs with different mechanisms of action is urgently needed. Emerging data support ketamine’s rapid and sustained anti-obsessional effects in OCD. The proposed mechanistic trial would be the first to probe the role of ketamine’s opioid properties in modulating fronto-striatal circuitry and bringing about reduction of OCD symptoms.

PI_NAMEs: RODRIGUEZ, CAROLYN I (contact)

PROGRAM_OFFICER_NAME: SABBAGH, JONATHAN JACOB

PROJECT_TERMS: Acute;Adult;antagonist;Anti-Cholinergics;antidepressant effect;arm;brain abnormalities;Childhood;cognitive control;cohort;Corpus striatum structure;cost;Data;Development;Diameter;Direct Costs;Drug Exposure;economic cost;Exposure to;Facilities and Administrative Costs;financial incentive;Functional disorder;Functional Magnetic Resonance Imaging;Funding Opportunities;Hour;Human;Hyperactivity;improved;Inferior;Insula of Reil;Ketamine;Major Depressive Disorder;Medial;Mediating;Memantine;Midazolam;Modeling;Morbidity - disease rate;Morphine;mu opioid receptors;N-Methylaspartate;Naltrexone;neural;neural circuit;neuroimaging;NMDA receptor antagonist;Obsessive-Compulsive Disorder;Opioid;Opioid agonist;Opioid Antagonist;Opioid Receptor;Oral;Participant;patient engagement;Pharmaceutical Preparations;Placebos;Prefrontal Cortex;Productivity;Prolactin;Property;Psychiatric therapeutic procedure;Randomized;Receptor Activation;Refractory;Reporting;response;Rest;Rewards;Role;Saline;Selective Serotonin Reuptake Inhibitor;Serum;Severities;Speed;Symptoms;System;Testing;Therapeutic;Time;Work

PROJECT_TITLE: Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCD

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Diabetes;Immunotherapy;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: PROJECT NARRATIVE  β-cells derived from human stem cells represent a transformative, unlimited source of insulin-producing cells for the treatment of type 1 diabetes, but translation of these cells is hindered by limited development of mature insulin-producing cells and the lack long-term engraftment and function without chronic immunosuppression. The objective of this project is to develop biomaterials for the transplantation of human stem cell-derived β-cells that promote maturation and function of the cells while also protecting the cells from attack by the immune system without the need for long-term systemic immunosuppression.

PI_NAMEs: GARCIA, ANDRES J (contact);SHIRWAN, HAVAL

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Acceleration;Address;Adhesives;Adult;Adverse effects;Affect;arm;Autoimmune;Autoimmune Diseases;Beta Cell;Biochemical;Biocompatible Materials;Biophysics;Blood Glucose;Body Weight;C-Peptide;Cadaver;Cell Maturation;Cell Physiology;cell replacement therapy;Cell Transplantation;Cells;Characteristics;Child;Chronic;Clinical;clinical translation;Clinical Trials;Cues;Cytoprotection;Development;diabetic;Diagnosis;Encapsulated;Engineering;Engraftment;ethylene glycol;euglycemia;Evaluation;Extrahepatic;Fasting;Fatty acid glycerol esters;Formulation;Foundations;Future;Gel;Glucose;Glucose tolerance test;glycemic control;Greater omentum;Health Care Costs;Hematopoietic stem cells;Homologous Transplantation;Human;human embryonic stem cell;human embryonic stem cell transplantation;human pluripotent stem cell;human stem cell-derived;human stem cells;humanized mouse;Hydrogels;Hypoglycemia;Immune;Immune mediated destruction;Immune system;Immunocompetent;Immunocompromised Host;Immunology;immunoregulation;Immunosuppression;Immunosuppressive Agents;improved;In Vitro;induced pluripotent stem cell;innovation;Insulin;insulin secretion;Insulin-Dependent Diabetes Mellitus;islet;Islets of Langerhans Transplantation;Ligands;Lymphocyte;Maleimides;mechanical properties;Modeling;Monitor;mouse model;Mus;nonhuman primate;novel;novel strategies;Ovarian;Patients;Peptide Hydrolases;Peripheral Blood Mononuclear Cell;Permeability;Phase III Clinical Trials;Population;prevent;Signal Transduction;Site;Source;stem cell biology;stem cells;Structure of beta Cell of islet;Technology;Translations;Transplantation;Vascularization;Vasculogenic;Work

PROJECT_TITLE: BIOMATERIALS FOR STEM CELL-DERIVED BETA CELL TRANSPLANTATION

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-V(02)M]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Physical Injury - Accidents and Adverse Effects

PHR: NARRATIVE The absence of a universally accepted, standardized fracture classification system is a critical barrier in the development of research on how best to treat proximal humerus fractures (PHF). A standardized approach for PHF classification can be accomplished with computer assisted image analysis of X-rays, and archived X-rays stored in the medical records of past patients will help inform how to treat current and future patients. The use of computers to classify fractures will not only enable historical patient data to be used for research on PHF treatment effectiveness, but also has the potential to improve the accuracy and efficiency of fracture diagnosis in clinical practice and thereby improve patient outcomes.

PI_NAMEs: FLOYD, SARAH BAUER (contact)

PROJECT_TERMS: Acute;Adoption;Adult;Archives;Area;Caring;Centers of Research Excellence;Cessation of life;Characteristics;Classification;clinical care;clinical practice;Clinical Practice Guideline;clinically relevant;Complex;Computer Models;Computer-Assisted Image Analysis;Computers;Consult;Data;Data Set;Decision Making;deep learning;deep learning model;deep neural network;Development;Diagnosis;Diagnostic Imaging;Dislocations;E-learning;Elderly;Electronic Health Record;electronic health record system;evidence based guidelines;Evidence based treatment;experience;Foundations;Fracture;Future;Generations;Goals;Health;Humeral Fractures;Image;Image Analysis;improved;Individual;individual patient;Informatics;Injury;interest;Joints;Label;Location;Long term disability;Medical Records;Methods;Modeling;Neural Network Simulation;Operative Surgical Procedures;Orthopedics;Outcome;Pain;Patient-Focused Outcomes;Patients;Pattern;Performance;Persistent pain;personalized medicine;Physicians;practice setting;prisma;Process;prognostic value;Quality of Care;Recommendation;Records;Reporting;Research;research and development;ROC Curve;Roentgen Rays;Shoulder;Specialist;Standardization;Surgeon;Surgical complication;System;Testing;therapy development;Training;Trauma;treatment choice;Treatment Effectiveness;United States;usability;Validation;Work;X-Ray Medical Imaging

PROJECT_TITLE: The Application of Deep Learning Methods for Proximal Humerus Fracture Feature Identification


PHR: Narrative Circadian rhythms, our 24 daily biological rhythms, control nearly all our basic biological functions and are sensitive to the environment. The overall vision of this research program is a multifaceted and innovative approach to understanding the underlying mechanisms of the human circadian system and its role in human health leading to integration of the temporal axis of our biology into preventative clinical care and treatment.

PI_NAMEs: LANE, JACQUELINE MARIE (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Address;Behavior;Behavioral Assay;biobank;Biological Assay;Biological Process;Biological Rhythm;Biology;Cardiometabolic Disease;Caring;cell type;Cellular Assay;circadian;circadian biology;Circadian Dysregulation;circadian pacemaker;Circadian Rhythm Disorder;Circadian Rhythms;Clinical;clinical care;Clinical Treatment;Development;Disease;Drosophila genus;educational atmosphere;Environment;experience;follow-up;Future;Genes;Genetic;Genetic Population Study;Genetic study;Goals;Health;Human;Human Genetics;Individual;innovation;insight;Intervention;Investigation;knockout gene;Knowledge;Lead;Link;Malignant Neoplasms;Methods;Molecular;neuropsychiatric disorder;novel;novel therapeutics;Outcome;Pathway interactions;pharmacologic;Pharmacologic Substance;Phenotype;Physiology;Population;Positioning Attribute;programs;rare variant;Research;risk prediction;risk stratification;Role;success;System;tool;translational applications;Vision;Workplace

PROJECT_TITLE: Genetics of human circadian rhythms: using sequencing, novel phenotyping methods, and functional assays to move towards a deeper understanding of circadian mechanisms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-L(55)R]


ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative The proposed research is relevant to public health as it focuses on developing mathematical algorithms for understanding and tracking the physiological processes and health states related to inflammation, metabolism, fatigue, and interoceptive awareness. As wearable monitoring rises in popularity, and new portable physiological monitoring devices become available for continuous monitoring of physiological signals, the dynamic response to external influences such as surgery, medication, disease, and environmental inputs can be quantified. The multimodal estimators for sensing health proposed here will offer insights into the complexity of interactions between physiological signals, which will significantly improve medical diagnosis and patient outcomes by also considering the medical expertise of physicians, and eventually help inform treatments and interventions to improve the quality of healthcare.

PI_NAMEs: FAGHIH, ROSE  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Affect;Algorithms;Awareness;Biological Response Modifiers;Cardiac Surgery procedures;Clinical;Clinical Data;computerized tools;cytokine;Data;data de-identification;Data Set;Devices;Diagnosis;Disease;Endocrinology;Eye Movements;Fatigue;Feedback;Goals;Health;health care quality;Homeostasis;Hormones;Immune response;improved;individualized medicine;Infection;Inflammation;insight;Interdisciplinary Study;Intervention;Knowledge;Label;Laboratories;mathematical algorithm;Measurement;Medical;Metabolism;Modeling;Monitor;monitoring device;multimodality;Neurons;Neurosciences;neurosurgery;Operative Surgical Procedures;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Physicians;Physiologic Monitoring;Physiological;Physiological Processes;Play;portability;Production;programs;Psychiatry;Public Health;Publishing;Recovery;Research;response;Rheumatology;Role;Signal Transduction;Stimulus;Stress;System;wearable device;wearable monitor

PROJECT_TITLE: MESH: Multimodal Estimators for Sensing Health


NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Eye Disease and Disorders of Vision;Prevention;Transplantation

ORG_NAME: SCHEPENS EYE RESEARCH INSTITUTE

PHR: Corneal transplantation is the most common form of tissue grafting, and diabetes affects over 10% of the US population, accounting for over 34 million cases. Remarkably, while there is increasing data implicating a history of diabetes among tissue donors as a risk factor for subsequent transplant failure, there is little scientific insight into the mechanisms that underlie this association. This grant proposes to continue our ongoing investigations that suggest a strong link between the diabetic state and activation of resident immune cells in the tissue, a line of investigation that could potentially have major implications for eye banking and corneal transplantation.

PI_NAMEs: DANA, REZA  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Accounting;Adult;Affect;Algorithms;Allografting;American;Antigen-Presenting Cells;Antigens;Area;Cell Maturation;cell motility;Cell Survival;Cells;Coculture Techniques;Cohort Studies;Cornea;corneal allograft;cytokine;Data;Diabetes Mellitus;diabetic;Diabetic mouse;Endothelium;Epidemic;Exclusion;Exhibits;experience;Eye Banks;Eye Surgeon;Failure;Functional disorder;glycemic control;Graft Rejection;Graft Survival;Grant;Homeostasis;Immune;Immunity;Impaired healing;Impairment;improved;Inflammation;Inflammatory;insight;Insulin;Investigation;isoimmunity;Keratoplasty;Kinetics;Knowledge;Letters;Link;Longevity;Lymphoid Tissue;Measures;Mediating;Mus;non-diabetic;novel;Operative Surgical Procedures;Organ Transplantation;Outcome;Panthera leo;Penetrating Keratoplasty;Penetration;Persons;Phenotype;Population;Prevalence;Procedures;prophylactic;Recording of previous events;Registries;Regulatory T-Lymphocyte;Reporting;response;Risk;Risk Factors;Risk Reduction;risk stratification;Role;success;Survival Rate;Techniques;Testing;Tissue Donors;Tissue Grafts;Tissues;Transplantation;United States

PROJECT_TITLE: The Impact of Donor Diabetes on Corneal Immune Cells and Graft Survival

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Genetics;Human Genome;Neck Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: SEATTLE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE The lack of understanding of the molecular mechanisms that drive chronic neck pain has hampered the development of effective mechanism-specific therapeutics. We will use RNA sequencing on joint and nerve tissues of patients with chronic and acute neck pain coupled with computational biology methods and careful patient phenotyping to examine how molecules produced in the diseased tissue drive chronic pain. Our work has the potential to reveal new molecular targets for future drug development.

PI_NAMEs: CURATOLO, MICHELE  (contact);HOFSTETTER, CHRISTOPH PAUL;PRICE, THEODORE J.

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Acute;Acute Pain;Arthritis;arthropathies;Atlanto-Axial joint;Bilateral;burden of illness;Cell Proliferation;Cells;Cervical spine;Characteristics;Chronic;Chronic neck pain;chronic pain;chronic pain patient;Clinical;clinical pain;cohort;Computational Biology;Coupled;Data;Databases;Development;differential expression;disability;Disease;drug development;Electrophysiology (science);Fracture;Future;Genes;Genetic Transcription;Genome;Genomics;Health Expenditures;Human;Individual;Infiltration;Inflammatory;innovation;insight;Joints;Knowledge;Ligands;Link;Macrophage;Maps;Methods;Modeling;Molecular;molecular sequence database;Molecular Target;Neck;Neck Pain;Nerve;nerve supply;Nerve Tissue;Nervous System;Neurons;Neurosciences;new therapeutic target;Nociceptors;Operative Surgical Procedures;opioid epidemic;Organ Donor;Pain;Pain Measurement;pain outcome;pain patient;pain sensitivity;pain signal;painful neuropathy;Painless;Pathologic;Pathway interactions;Patient Recruitments;Patients;Persons;pharmacologic;Phenotype;pressure;radicular pain;receptor;Resolution;Sampling;Sensory;Side;Signal Transduction;Site;Spinal Ganglia;stem;Stimulus;Techniques;Testing;Therapeutic;Tissue Sample;Tissues;transcriptome;transcriptome sequencing;transcriptomics;Vertebral column;Work

PROJECT_TITLE: Identifying novel therapeutic targets for chronic neck pain: RNA-sequencing in human painful atlanto-axial arthropathy


NIH_SPENDING_CATS: Immunotherapy

ORG_CITY: BOSTON

PHR: Project Narrative While transfusion of red blood cells (RBCs) represents one of the most common therapeutic interventions in medicine, RBC transfusion is not without risk. Development of alloimmune responses to RBC antigens can lead to adverse clinical reactions and increased mortality. While RBC alloimmunization can become particularly problematic when patients develop alloantibodies against multiple alloantigens, what factors may regulate the development of additional alloantibodies following initial alloimmunization remains largely unknown. These studies will use pre-clinical models to elucidate key initiating factors responsible for RBC alloimmunization in an effort to reduce or eliminate this process in transfusion-dependent individuals. !

PI_NAMEs: ARTHUR, CONNIE M (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Adoptive Transfer;Alloantigen;Alloimmunization;Antibody Formation;Antigen Targeting;Antigens;B-Cell Activation;B-Cell Antigen Receptor;B-Lymphocytes;CD4 Positive T Lymphocytes;Cellular Structures;Chronic;Clinical;Data;Dendritic Cells;Development;enhancing factor;Erythrocyte Transfusion;Erythrocytes;Event;Future;Genetic Polymorphism;Goals;Immune;immune function;Immune system;Immunologic Factors;Immunologics;Immunology;imprint;Individual;Inflammation;innate immune pathways;insight;Interferon Type I;interferon-alpha B;Isoantibodies;Mediating;Medicine;memory CD4 T lymphocyte;Morbidity - disease rate;mortality;Ovum;Pathway interactions;Patients;Peptide Initiation Factors;Poly I-C;Population;Pre-Clinical Model;prevent;Process;Reaction;Receptor Signaling;response;Risk;Role;Series;stem;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic Intervention;Toll-like receptors;trafficking;Transfusion;Viral;Work

PROJECT_TITLE: Examining the Mechanisms of RBC Alloimmunization Hyperresponders

STUDY_SECTION: HT

STUDY_SECTION_NAME: Hemostasis and Thrombosis Study Section.  Committee was terminated on 11/30/2020. [HT]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Regenerative Medicine

ORG_CITY: MOSCOW

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF IDAHO

ORG_STATE: ID

PHR: Public Health Impact Statement: Macrophage Determinants of Retinal Regeneration In both zebrafish and humans, an immune response occurs in reaction to retinal damage and death of neurons, but whereas zebrafish regenerate their damaged retinal neurons, humans develop a gliotic response. In addition, responding immune cells (specifically microglia and macrophages) appear to contribute to pathology in humans. This project will investigate contributions of microglia and macrophages to retinal degeneration and regeneration in the zebrafish model system, to provide foundational knowledge that will ultimately inform the design of therapeutic strategies and treatments for human retinal injury and disease.

PI_NAMEs: MITCHELL, DIANA  (contact)

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: Acute;Affect;Biological Models;cell type;Cells;Central Nervous System;Cessation of life;Characteristics;Comparative Study;cytotoxic;Data;design;Disease;Foundations;Future;Gene Expression;Gene Expression Profiling;Gliosis;Goals;Growth;healing;Health;Heterogeneity;Histologic;Human;Immune;Immune response;Infiltration;Inflammatory;Inflammatory Response;Injury;Intervention;Knowledge;Lesion;Macrophage;Mammals;Measures;Mediating;Microglia;Modeling;Molecular;Morphology;Muller's cell;mutant;Natural regeneration;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;neuroinflammation;neuron loss;neuron regeneration;Neurons;novel;Organism;Outcome;Participant;Pathologic;Pathology;Pathway interactions;Peripheral;pharmacologic;Phase;Phenotype;Physiological;Population;Population Heterogeneity;Process;Public Health;Publishing;Reaction;regenerative;regenerative approach;Regenerative capacity;repaired;Research;response;Retina;retinal damage;Retinal Degeneration;Retinal Diseases;retinal neuron;retinal regeneration;Role;Shapes;Signal Transduction;Source;System;targeted treatment;Testing;Therapeutic;Time;Tissues;tool;trafficking;transcriptome;Vesicle;Vision;Work;wound healing;Zebrafish

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: BINGHAMTON

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

PHR: Project Narrative: We seek to address a gap in the fundamental understanding of mechanisms in two areas of contemporary catalysis – photoredox catalysis and biocatalysis by engineered enzymes. This proposal utilizes a battery of experimental and theoretical mechanistic probes to gain atomistic insight into several fundamental reactions. The outcome of the proposed studies will enable the rational design and development of more powerful chemical transformations for the synthesis of medicinally relevant molecules.

PI_NAMEs: HIRSCHI, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Mechanistic Investigation into Modern Catalytic Reactions


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Machine Learning and Artificial Intelligence

ORG_CITY: Newark

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE This project aims to develop microscale machines for controlling cell fate and driving the formation of cellular structures. Using this technology would enable us to reduce noise in gene expression in cells to support gene- and cell- based therapies for application in regenerative medicine.

PI_NAMEs: DAS, SAMBEETA  (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: 3-Dimensional;automated algorithm;Automobile Driving;behavior change;Biological;biological systems;Biology;cell behavior;Cell Communication;Cell Culture Techniques;Cell Fate Control;Cell Therapy;cell type;Cells;Cellular Structures;Cellularity;Complex;design;Development;Diffusion;Embryo;Engineering;Event;Feedback;Fibrosis;Gene Expression;Genes;human-in-the-loop;In Vitro;Individual;Malignant Neoplasms;Mediating;Methodology;Methods;microrobot;Mitotic;morphogens;Noise;novel;optogenetics;Organ;Organoids;Pattern;Pattern Formation;Positioning Attribute;Reaction;Regenerative Medicine;Research;Shapes;Signal Transduction;Signaling Molecule;spatiotemporal;Stimulus;Surface;System;Technology;Tissues;Work

PROJECT_TITLE: Controlling Cellular Fate using Micromachines


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE These studies seek to understand the impact of dendritic cells on therapeutic responsiveness to radiation therapy in pancreas cancer.

PI_NAMEs: DENARDO, DAVID G (contact);DESELM, CARL

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: Aftercare;Agonist;Animal Model;Animals;antigen-specific T cells;Antigens;Automobile Driving;Biochemical;Biological Assay;Biological Markers;Bone Marrow;cancer cell;cancer type;checkpoint therapy;chemotherapy;Chemotherapy and/or radiation;Circulation;Clinical;Clinical Research;clinical translation;Clinical Trials;cohort;Combined Modality Therapy;Conduct Clinical Trials;Correlative Study;Cross Presentation;Cytometry;Cytotoxic agent;Data;Dendritic Cells;density;Development;Exclusion;experimental study;FLT3 gene;Functional disorder;Future;Human;Image;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immunity;Immunologic Tests;Immunologics;Immunosuppression;immunosuppressive macrophages;Immunotherapy;Impairment;improved;Infiltration;Ligands;Limes;Malignant neoplasm of pancreas;member;mouse model;Myeloid Cells;Nature;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;patient response;Patients;Phase I/II Clinical Trial;Positioning Attribute;pre-clinical;Productivity;Prognosis;Radiation therapy;Reporting;Research;Research Personnel;response;restraint;Role;Safety;Signal Transduction;single cell analysis;Stimulant;T cell infiltration;T cell response;T-Lymphocyte;Testing;Therapeutic;Tissues;TNFRSF5 gene;Translating;Treatment Efficacy;treatment strategy;trial design;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;Tumor-Derived;Work

PROJECT_TITLE: Re-wiring PDAC Tumor Immunity Through Dendritic Cells

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE: The Canary CREST Program fulfills the mission of the Canary Center at Stanford by educating and training a new generation of scientists as they explore new research experiences in the biological sciences. The importance of this training offered at the undergraduate level, with a focus on cancer early detection, provides a new understanding of career opportunities in biomedical research, including clinical translational science.

PI_NAMEs: DEMIRCI, UTKAN  (contact);PITTERI, SHARON

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Achievement;anti-cancer research;Area;Award;Biochemistry;Bioinformatics;Biological;Biological Sciences;biomarker discovery;biomarker validation;Biomedical Engineering;Biomedical Research;Blood;Cancer Biology;cancer biomarkers;Cancer Diagnostics;cancer imaging;career;Career Choice;career development;clinical imaging;clinical translation;Communication;Communities;Country;Data Analyses;Dedications;design;Development;Device or Instrument Development;diversity and inclusion;Early Diagnosis;Education;education research;Educational workshop;effectiveness evaluation;effectiveness research;Engineering;Ensure;Ethics;Ethnic Origin;Evaluation;experience;Faculty;faculty mentor;Feedback;Fostering;Future;Generations;Goals;hands on research;imaging approach;in vivo;in-vitro diagnostics;Individual;innovation;Institution;Instruction;Interdisciplinary Study;Internships;Laboratory Research;liquid biopsy;Malignant Neoplasms;mathematical sciences;Medicine;meetings;Mentors;minimally invasive;Minority Groups;Mission;molecular imaging;multidisciplinary;Participant;physical science;Population;posters;Productivity;programs;Publications;Race;Recommendation;recruit;Reporting;Research;research facility;Research Personnel;Research Project Grants;Science;Scientist;Screening for cancer;Series;Serinus;Shapes;skills;socioeconomics;Structure;Students;success;summer internship;summer program;summer research;symposium;Talents;Testing;Training;Training Programs;Translational Research;Travel;undergraduate research experience;undergraduate student;Underrepresented Minority;Work;Writing

PROJECT_TITLE: CANARY CANCER RESEARCH EDUCATION SUMMER TRAINING (CANARY CREST) PROGRAM

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Project Narrative The proteinopathy condition of Alzheimer’s disease (AD) is the leading cause of dementia and the sixth leading cause of death in the United States. Indeed, it is estimated that 13.8 million Americans will be affected by AD by the year 2050 unless effective disease-modifying treatments are developed. We will characterize human neuronal and glial cell genomic and epigenomic signatures and networks that confer vulnerability to AD proteinopathies, such as amyloid-b, Tau or/and TDP-43, in order to identify new mechanistic drug targets and disease-modifying repurposable medicines that we will then evaluate in real-world patient data and in laboratory models of AD.

PI_NAMEs: BONAKDARPOUR, BORNA ;CHENG, FEIXIONG  (contact);FLANAGAN, MARGARET E;PIEPER, ANDREW A

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: abeta accumulation;Acetylation;Affect;Age;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;American;Amyloid beta-Protein;Animal Model;Astrocytes;ATAC-seq;Autopsy;biobank;Biological;Brain;brain cell;Brain region;Cause of Death;Cell Nucleus;cell type;Cells;Cerebellum;Clinical;Clinical Data;Cognitive;cohort;Complex;cost effective;Data;Data Analyses;Data Analytics;Dementia;Diflunisal;Disease;Disease associated microglia;Disease Progression;drug development;Drug Modulation;drug repurposing;Drug Targeting;Drug usage;effective therapy;epigenome;epigenomics;ethnic diversity;Freezing;Frontotemporal Dementia;Functional disorder;functional genomics;Funding;gene regulatory network;generative models;Genes;Genetic;genetic signature;genome sequencing;genome wide association study;genomic data;Genomics;Heterogeneity;Hippocampus;Human;human data;human disease;Individual;induced pluripotent stem cell;Inflammation;inflammatory marker;intercellular communication;Investigation;Knowledge Portal;Laboratories;Link;Medicine;Microglia;Molecular;mouse model;multimodal data;multimodality;multiple omics;Nature;Neocortex;Nerve Degeneration;Neuroglia;Neurons;neuropathology;novel;Outcome;Pathogenesis;Pathologic;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Pharmacological Treatment;Population;preclinical efficacy;Preclinical Testing;Process;protein TDP-43;Quantitative Trait Loci;Reproducibility;Research;resilience;Risk;risk variant;Sampling;Severities;sex;sildenafil;single cell genomics;single nucleus RNA-sequencing;stem cell model;Systems Biology;tau aggregation;tau Proteins;tau-1;Technology;Testing;transcriptome;Transgenic Mice;treatment response;United States;Universities;Vulnerable Populations;whole genome

PROJECT_TITLE: Characterize neuronal and glial cell-specific vulnerability to proteinopathies in Alzheimer's disease using multimodal single-nuclei genomic and epigenomic approaches


NIH_SPENDING_CATS: Biotechnology;Infectious Diseases

ORG_CITY: SANTA CRUZ

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: Shelbi L Russell Project Narrative Microbial symbiosis is ubiquitous among eukaryotes and has enabled many remarkable lifestyles and strategies, however little is known about the cellular mechanisms that maintain these associations. The  Wolbachia  bacterial symbiont of many insect and filarial nematode species, exhibits a range of transmission strategies and is highly tractable in the lab. Here, I propose to use the K99 period of a NIH NIGMS Pathway to Independence Award to develop tools, datasets, and techniques that will enable me to ask deeper and more complex questions about host-symbiont interactions during the R00 phase.

PI_NAMEs: RUSSELL, SHELBI LIANNE (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Agriculture;Antibodies;Arthropods;Award;Bacteria;Bioinformatics;Biological Models;Biology;Candidate Disease Gene;Carbon;career;Career Transition Award;Cell Culture System;Cell Line;Cell Physiology;Cells;Cellular biology;Chloroplasts;Communities;Complex;Conflict (Psychology);Data Set;Development;Diet;Disease Vectors;Disparate;Doctor of Philosophy;Dominant-Negative Mutation;Drosophila genus;Drosophila melanogaster;Ecosystem;endosymbiont;Environment;Epidemic;Equilibrium;Eukaryota;Evolution;Exhibits;feeding;fly;Funding;Future;Generations;Genes;Genome;Genomics;Germ Lines;Homologous Gene;Horizontal Disease Transmission;Human;In Vitro;in vivo;Individual;Infection;Inherited;Insecta;insight;Intuition;Kinesin;knock-down;Label;Learning;learning strategy;Life Style;Light;Mediating;Medicine;Methodology;microbial;Microtubules;Mitochondria;Modeling;Molecular;Molecular Biology;Motility;Motor;mutualism;National Institute of General Medical Sciences;Nature;Nematoda;Nitrogen;novel;Oogenesis;Organelles;Organism;Outcome;Parents;pathogen;Pathogenicity;Pathway interactions;Phase;Plants;Postdoctoral Fellow;Process;Proteins;Recording of previous events;Reproduction;Research;Resistance;Resources;skills;Source;symbiont;Symbiosis;System;Techniques;Testing;Time;tool;trait;transmission process;United States National Institutes of Health;vector control;Vent;Vertical Transmission;Western Blotting;Wolbachia;Work;X-Ray Crystallography

PROJECT_TITLE: Cellular mechanisms of endosymbiont transmission between host generations