NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Epilepsy;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Rare Diseases;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Epilepsy is a chronic, debilitating neurological disorder that affects millions of people across the globe. Epilepsy due to head injury, known as post-traumatic epilepsy, represents an opportunity to understand the changes in the brain that lead to epilepsy. This research will help us understand the unique structural and functional changes in the brain leading to post-traumatic epilepsy and develop tools for epilepsy risk stratification after head injury—a prerequisite for feasible clinical trials of therapies for the prevention of epilepsy.

PI_NAMEs: GUGGER, JAMES J (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Affect;animal data;Animal Model;Antiepileptogenic;Area;Atrophic;Axon;axon injury;Big Data;Bioinformatics;Biological Markers;biomarker identification;Brain;Brain imaging;brain magnetic resonance imaging;Caring;case control;Case Series;cerebral atrophy;Chronic;Clinical;Clinical Trials;cohort;Craniocerebral Trauma;Data;design;Development;Diffuse;Diffuse Brain Injury;Diffusion Magnetic Resonance Imaging;Disease;endophenotype;Epilepsy;Epileptogenesis;experience;experimental study;Frequencies;Functional Magnetic Resonance Imaging;Future;Goals;high risk;human data;Human Pathology;Image;improved;Injury;K-Series Research Career Programs;Knowledge;Lesion;Location;Magnetic Resonance Imaging;Magnetism;Maps;Measurement;Measures;Mentors;Mentorship;Methods;military injury;multimodal neuroimaging;multimodality;Nervous System Disorder;neural network;Neurobiology;neuroimaging;Neurology;Participant;Patient Care;Patients;Pennsylvania;Persons;Phenotype;Physicians;Play;Positioning Attribute;Post-Traumatic Epilepsy;prevent;preventable epilepsy;Prevention trial;Process;professor;Prognostic Marker;prospective;Records;Research;Rest;Risk;risk prediction;risk stratification;Role;Scientist;Seizures;Severities;skill acquisition;Statistical Models;study population;TBI Patients;Techniques;Temporal Lobe;Testing;Therapy Clinical Trials;Thick;tool;Training;translational study;Traumatic Brain Injury;Universities;Work

PROJECT_TITLE: Neuroimaging Phenotypes of Post-Traumatic Epilepsy

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Biotechnology;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Autism spectrum disorder (ASD) is a life-long neurodevelopmental disorder of which there are currently no effective treatments for due to a limited understanding of the underlying pathophysiology. This work focuses on understanding how ASD risk genes converge in the dendrites of pyramidal neurons in the prefrontal cortex, a brain region implicated in ASD etiology. This project will shed light on the cellular processes that contribute to ASD and may reveal new therapeutic strategies to rescue cellular and network functions.

PI_NAMEs: NELSON, ANDREW D (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Action Potentials;Adult;Advisory Committees;Affect;ANK2 gene;Ankyrins;Apical;Area;autism spectrum disorder;Binding;Biological Process;brain circuitry;Brain region;Categories;Cell Physiology;Cognitive;Collaborations;Communication;CRISPR-mediated transcriptional activation;Dendrites;Detection;detector;Distal;effective therapy;Electrophysiology (science);Etiology;Functional disorder;gene discovery;Gene Expression Regulation;gene therapy;Generations;Genes;Genetic;Genetic Transcription;Genome;Glutamates;Goals;Heterozygote;high risk;hippocampal pyramidal neuron;Image;Imaging Techniques;Impairment;Individual;insight;member;Membrane;model of autism spectrum disorder;Molecular;mouse model;Mus;Neocortex;neocortical;network dysfunction;Neurodevelopmental Disorder;Neuronal Dysfunction;Neurons;novel therapeutic intervention;Pattern;Phenotype;Physiological;Physiology;Postdoctoral Fellow;Prefrontal Cortex;Process;Proteins;Pyramidal Cells;Regulator Genes;risk variant;Role;Scaffolding Protein;SCN2A protein;social;Sodium Channel;Synapses;synaptic function;Synaptic plasticity;Technology;Testing;Therapeutic;therapy development;Training;Translations;two-photon;voltage;Work

PROJECT_TITLE: Convergent cellular and network mechanisms of ASD risk genes

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-M (05)]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Microbiome;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_CITY: RICHMOND

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE This career development award proposes a multi-omic systems biology approach to elucidate the roles of the vaginal microbiome and psychological stress in progression of precancerous cervical lesions to cancer, notably, in the known disparities between Black and White women. The proposed plan will accelerate this early-stage investigator’s career trajectory to independence by providing targeted bioinformatic, statistical and molecular biology training to analyze microbiome and stress experience data, using an integrative systems biology framework to inform future clinically relevant prognostic biomarkers, risk stratification protocols, and interventions to intercept cervical cancer development.

PI_NAMEs: TOSSAS, KATHERINE Y (contact)

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: Acceleration;Address;Anti-Inflammatory Agents;Area;Award;Bioinformatics;Black Populations;Black race;black women;carcinogenesis;career;Caring;Cervical;cervical biopsy;Cicatrix;clinical development;clinically relevant;Data;Deposition;Development;Diagnosis;Disparity;dysbiosis;Ecological momentary assessment;Endocervical Curettage;Endocrine;Environment;Etiology;experience;follow-up;Future;Glycogen;Hemorrhage;high risk;Homeostasis;HPV positive;HPV vaccine acceptance;Human papilloma virus infection;Human Papillomavirus;Hydrocortisone;improved;Incidence;Infertility;Inflammation;insight;Intercept;Intervention;K-Series Research Career Programs;Lactobacillus;Lesion;Link;Malignant neoplasm of cervix uteri;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Mediating;Mediator;Mentorship;metabolic profile;Metabolism;microbiome;microbiome alteration;microbiome analysis;microbiome composition;Molecular Biology;multiple omics;outcome disparities;Pain;Pap smear;Pathway interactions;Pattern;Physiological;Predisposition;premalignant;Premature Birth;Procedures;Prognosis;prognostic;Prognostic Marker;Property;prophylactic;protective effect;Protocols documentation;psychologic;Psychological Stress;Race;racial difference;racial disparity;Reporting;Research;Research Personnel;response;Risk;risk stratification;Role;Salivary;screening;skills;Spontaneous abortion;Squamous intraepithelial lesion;Stress;Systems Biology;targeted treatment;Taxonomy;Testing;Time;tool;Training;translational scientist;Vagina;vaginal microbiome;White Women;Woman;women's diagnosis

PROJECT_TITLE: Elucidating the Role of the Vaginal Microbiome in Racial Disparities in Precancerous Cervical Lesions: A Multi-level Study

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: BIOLOGY

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative This proposal aims to investigate how stochastic neuronal circuit is built during development by using Drosophila color vision circuit as a model. Our work will reveal general principles coordinating stochastic cell fate choice and synaptic partner matching during circuit assembly. The molecules underlying synaptic connectivity during development identified here will also provide insights into the regenerative mechanisms and novel therapeutic approaches for neurodegenerative diseases.

PI_NAMEs: CHEN, YU-CHIEH  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Ablation;Address;Advisory Committees;Afferent Neurons;Award;Axon;axon guidance;Brain;Brain region;career;Cell Adhesion Molecules;cell fate specification;Cell surface;cell type;Cells;Code;Collaborations;Color;Color Visions;Dasen;Data Set;Dedications;Detection;Development;Distal;Drosophila genus;Electron Microscopy;Ensure;experimental study;Eye;Face;fly;Funding;gain of function;Genetic;genetic manipulation;Goals;Grant;Human;Image;insight;interest;Invertebrates;Knowledge;Logic;loss of function;Mediating;Mentors;Mentorship;Modeling;Molecular;Motion;mutant;Neurites;Neurodegenerative Disorders;neurodevelopment;neuronal circuitry;neuronal survival;Neurons;Neuropil;New York;novel;novel therapeutic intervention;Olfactory Pathways;Optic Lobe;Pathway interactions;Pattern;Photoreceptors;postsynaptic;presynaptic;Process;programs;regenerative;Research;Resolution;Retina;Robin bird;Rodent;Role;Scientist;sensory system;Side;single cell genomics;single-cell RNA sequencing;skills;Specific qualifier value;Specificity;Synapses;synaptogenesis;Testing;tool;Training;transcriptome;Universities;Vertebrates;Work

PROJECT_TITLE: Molecular control of stochastic color vision circuit assembly

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (03)]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Lung;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Pulmonary Hypertension

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: NARRATIVE  A multi-lineage, transcriptional, and epigenetic understanding of alveologenesis and re-alveologenesis upon injury is a timely response to the burden of pulmonary diseases and leverages latest single-cell technology. The proposed project leverages our expertise in multiple lung cell lineages, single-cell genomics, mouse genetics, and bioinformatics; tackles fundamental questions of cell fate, plasticity, and signaling; relates to pulmonary diseases during development and upon injury; and opens the door to single-cell functional genomics applicable to any organ.

PI_NAMEs: CHEN, JICHAO  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Acute Lung Injury;Alveolus;Bioinformatics;Blood capillaries;Bronchopulmonary Dysplasia;burden of illness;Cause of Death;Cell Lineage;Cell Physiology;cell type;Cells;COVID-19;Development;Endothelium;Epigenetic Process;Epithelium;Foundations;functional genomics;Gases;Genetic Transcription;genome wide association study;Injury;Knowledge;Lung;Lung Diseases;Mesenchymal;mouse genetics;novel;Organ;Population;Pulmonary Hypertension;Reaction Time;Regulation;Signal Transduction;single cell genomics;single cell technology;Untranslated RNA;Variant

PROJECT_TITLE: Transcriptional and epigenetic mechanisms of alveologenesis and re-alveologenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-I (O1)]


ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Project narrative Lymphatic dysfunctions are associated with many cardiovascular and metabolic diseases such as obesity, atherosclerosis, lymphedema, and immune suppression, which have limited or no clinical approaches to treat. Restoring impaired lymphatic vessels and maintaining a proper lymphatic drainage plays a crucial role in lipid metabolism and cholesterol transport. The proposed studies in this project are significant as a better understanding of these processes may enable the development of novel therapeutic treatment for cardiovascular and metabolic diseases.

PI_NAMEs: CUI, KUI  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: absorption;Adaptor Signaling Protein;Address;Adult;Affect;Alleles;Animal Model;Aorta;Apolipoprotein E;Arterial Fatty Streak;atherogenesis;Atherosclerosis;Attenuated;Blood;Blood Vessels;Cardiovascular Diseases;Cells;Cholesterol;Chronic;Clinical;combat;Data;Deposition;Development;diet-induced obesity;Disease;Embryo;epsin;Family;Fatty acid glycerol esters;Fluid Balance;FOXC2 gene;gain of function;Genetic;Genetic Transcription;Goals;Health;High Fat Diet;Human;hypercholesterolemia;Immune;Immune response;Immunosuppression;improved;In Vitro;Inflammation;Insulin Resistance;Intercellular Fluid;lipid metabolism;lipid transport;Lipids;loss of function;lymph flow;Lymphangiogenesis;Lymphatic;lymphatic development;lymphatic drainage;lymphatic dysfunction;Lymphatic Endothelial Cells;Lymphatic Endothelium;Lymphatic function;Lymphatic System;lymphatic vessel;Lymphedema;Macrophage;Medical;Mentors;Metabolic;Metabolic Diseases;Metastasis Suppression;Modeling;Molecular;mouse model;Mus;nanoparticle delivery;nanotherapy;new therapeutic target;novel;novel therapeutics;Obese Mice;obese patients;Obesity;older adult;Pathogenesis;Pathologic;Peripheral;Phase;Physiological;Play;post-doctoral training;Postdoctoral Fellow;prevent;Process;Publishing;regenerative;Research Personnel;Resolution;restoration;reverse cholesterol transport;Role;Signal Induction;Signal Transduction;Stream;symposium;System;targeted treatment;Techniques;Testing;Therapeutic;Tissues;tool;trafficking;transcription factor;Tumor Suppression;Vascular Endothelial Growth Factor Receptor-3;Work

PROJECT_TITLE: Novel role of Foxc2 in regulating metabolic disease

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI (OA)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Genetics;Microbiome

ORG_CITY: LOS ANGELES

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Factors that promote microbial colonization in complex and dynamic communities such as the human gastrointestinal microbiome are poorly understood, but knowledge of their functions could lead to therapeutic interventions that reverse dysbiotic states. We predict that rapid gene diversifiers, such as Diversity Generating Retroelements (DGRs), provide bacteria with selective fitness advantages through rapid evolution of ligand binding proteins that facilitate colonization within the gut microbiome. By testing this prediction, we expect to generate a toolkit for engineering adaptative systems in beneficial microbes that allow efficient engraftment in the gut microbiome.

PI_NAMEs: MACADANGDANG, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Acceleration;Adhesives;Advisory Committees;Anatomy;Antibiotics;Archaea;Award;Bacteria;Bacterial Adhesins;Bacterial Genes;Bacteroides;beneficial microorganism;Binding Proteins;Bioinformatics;Cardiovascular Diseases;career development;Cells;Codon Nucleotides;Communities;competitive environment;Complex;Computing Methodologies;deep sequencing;Development Plans;Diet;Disease;dysbiosis;Ecology;Ecosystem;Engineering;Engraftment;Environment;Evolution;Exhibits;experience;fitness;Funding;Generations;Genes;Genetic;genetic element;Genome;genome-wide;Genotype;Gnotobiotic;Goals;Growth;gut microbiome;gut microbiota;Health;Human;in vivo;Inflammatory Bowel Diseases;insight;Knowledge;Ligand Binding;Ligands;Maintenance;Mass Spectrum Analysis;Measures;Mediating;member;Membrane;Mentors;Microbe;microbial colonization;microbial community;microbiome;mouse model;multidisciplinary;Mutagenesis;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutics;Nucleotides;Nutritional;Obesity;Pattern;Periplasmic Proteins;Permeability;Phenotype;Pilum;programs;protein function;Proteins;Regulation;Research;response;Retroelements;Role;Scientific Inquiry;Shapes;Signal Transduction;structural biology;Structure;System;Technology;Testing;Therapeutic Intervention;timeline;Training;Variant;Virus;Work

PROJECT_TITLE: Diversity generation in the gastrointestinal microbiome

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ORG_DEPT: PATHOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: NARRATIVE Brain metastasis remains a serious complication for melanoma patients. We aim to study the contribution of CNDP1 to melanoma cells’ adaptation to the brain microenvironment, and assess the value of targeting this enzyme as a novel therapeutic approach against these tumors.

PI_NAMEs: HERNANDO, EVA  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Amino Acids;Amino Acyl Transfer RNA;Area;Back;biological adaptation to stress;Biological Assay;Blood - brain barrier anatomy;Brain;brain parenchyma;brain size;Cancer cell line;Cancer Patient;cancer type;Carnosine;Cell Proliferation;Cells;Cephalic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Codon Nucleotides;cohort;Complementary DNA;Complication;Culture Media;Data;Defect;Diabetic Nephropathy;diabetic patient;dietary supplements;Dipeptidases;Disease;Doxycycline;Ectopic Expression;Electron Microscopy;Environment;Enzymes;Excision;Flow Cytometry;FRAP1 gene;Gene Silencing;Genes;Genetic;Genetic Polymorphism;Genus Hippocampus;Global Change;Growth;Histidine;Immunotherapy;Impairment;improved;In Vitro;in vivo;inhibitor;Injections;Investigation;knock-down;Ligase;Liver;loss of function;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Melanoma;Melanoma Cell;Melanoma patient;Metabolic;metabolomics;Metastatic malignant neoplasm to brain;Metastatic Melanoma;Mitochondria;Mitochondrial Proteins;Modeling;Molecular;Morphology;mouse model;mRNA Decay;Muscle;mutant;Neoplasm Metastasis;neuroprotection;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Oxidative Phosphorylation;Oxidative Stress;Patient-Focused Outcomes;Patients;pharmacologic;Play;pre-clinical;Pre-Clinical Model;preference;prevent;Proliferating;Proteins;Proteomics;Radio;research clinical testing;ribosome profiling;RNA;Role;small hairpin RNA;small molecule inhibitor;Specificity;Supplementation;Surface;Systemic Therapy;Testing;Therapeutic Effect;therapeutic evaluation;transcriptome sequencing;transcriptomics;Translations;tumor;tumor progression;tumorigenic;Up-Regulation;Xenograft procedure;β-Alanine

PROJECT_TITLE: Metabolic adaptations in melanoma brain metastasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-P (O2)]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Complementary and Integrative Health;Digestive Diseases;Emerging Infectious Diseases;Gene Therapy;Genetics;Infectious Diseases;Microbiome

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Targeted strategies to combat enteric infections are needed to overcome deficiencies with conventional antibiotic treatment such as access and stability in the GI tract, antibiotic resistance, and collateral damage to the native microbiome. Within this proposal, I will (1) define and expand the expression capacity of Saccharomyces cerevisiae var. boulardii (Sb)-produced anti-infective therapeutics in conditions mimicking the gut environment, and (2) establish tolerability and treatment outcomes of engineered Sb carrying a variety of anti-pathogen payloads as single agents or in combination. This work will generate innovative engineered probiotic therapies that can directly and safely mitigate the specific pathogens Clostridioides difficile and enterotoxigenic Bacteroides fragilis from the mammalian gut.

PI_NAMEs: WALLACE, MIRANDA  (contact)

PROGRAM_OFFICER_NAME: KIM, HYE-SOOK

PROJECT_TERMS: Aerobic;Alternative Therapies;Anti-Infective Agents;anti-microbial peptide;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;antibody mimetics;antimicrobial;Bacteria;Bacteriophages;Bacteroides fragilis;Bile Acids;Binding;Binding Proteins;Biological Availability;built environment;Chemicals;Clinical;clinically significant;Clostridium difficile;Collection;combat;combinatorial;commensal microbes;conventional therapy;Development;Disease;Dose;efficacy testing;Encapsulated;endolysin;Engineered Probiotics;engineered T cells;Engineering;Ensure;enteric infection;enteric pathogen;Environment;experimental study;gastrointestinal;Gastrointestinal Diseases;gastrointestinal infection;Gastrointestinal tract structure;Gene Modified;Genetic;Genetic Engineering;gut microbes;gut microbiota;Health;Hospitalization;Host Defense;host microbiome;host microbiota;improved;In Situ;In Vitro;in vivo;Infection;Inflammation;Inflammatory;innovation;Lead;Malignant Neoplasms;Metabolic;microbiome;microbiota;Modeling;Morbidity - disease rate;mortality;Motivation;mouse model;Mus;nanoparticle;Natural Source;Nature;next generation;novel;Oral;Organism;pathogen;Pathogenesis;Peptide Hydrolases;Peptides;Phase;Population;potency testing;Predisposition;probiotic therapy;Probiotics;Production;promoter;protein function;Proteins;prototype;Regimen;Reporter;Resistance;Saccharomyces cerevisiae;Series;Signal Transduction;Site;Specificity;stem;stressor;Structure;System;targeted treatment;Temperature;Testing;Therapeutic;Therapeutic Effect;therapeutic protein;therapeutic target;Time;tool;Toxin;Treatment outcome;Treatment Protocols;United States;Virulence;Work;Yeast Model System

PROJECT_TITLE: Expanding the therapeutic capacity of Saccharomyces cerevisiae var. boulardii for the treatment of gastrointestinal infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 AM (01)]


NIH_SPENDING_CATS: Asthma;Eczema / Atopic Dermatitis;Endocrine Disruptors;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Lung;Pediatric;Prevention;Social Determinants of Health

PHR: PROJECT NARRATIVE The prevention of asthma development in children is a pressing, unmet need of utmost priority. There is also a need to identify periods of susceptibility to persistent environmental chemical exposures in children. The proposed research will determine if perfluoroalkyl substance (PFAS) exposures are associated with aeroallergen sensitization, a known precursor to asthma development, in young children (aged 24-47 months) risk for developing asthma.

PI_NAMEs: JACKSON-BROWNE, MEDINA SAMIRA (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: 3 year old;Address;Affect;African American;Age;Age Months;aged;airborne allergen;airway inflammation;Allergens;Allergic;Allergic Disease;allergic response;Antibodies;Antibody Formation;Asthma;asthma prevention;Atopic Dermatitis;bioaccumulation;Biological Markers;Biostatistical Methods;Black race;Boston;C-reactive protein;Canis familiaris;career;career development;Chemicals;Child;Childhood;Childhood Asthma;clinical investigation;Clinical Research;Clinical Trials;Clinical Trials Design;cytokine;Data;database design;Database Management Systems;Development;Dictyoptera;Disease;Doctor of Philosophy;early childhood;early life exposure;Eczema;Environment;environmental chemical;environmental chemical exposure;Environmental Risk Factor;Epidemiologist;Epidemiology;epidemiology study;Ethnic Origin;Exhalation;exposure reduction interventions;Exposure to;Felis catus;Fetal Development;Five-Year Plans;Food Packaging;Foundations;Future;Goals;Health;Helper-Inducer T-Lymphocyte;High Prevalence;high risk;high risk infant;Hispanic Populations;Home environment;Human;Hypersensitivity;IgE;Immune response;Immune system;Infant;Inflammation;inflammatory marker;Infrastructure;interest;Intervention;K-Series Research Career Programs;Life;Low income;man;Measures;Mediator;Mentors;modifiable risk;Modification;National Toxicology Program;Neighborhoods;neonate;Nitric Oxide;novel;parent grant;Pattern;Pediatric Hospitals;perfluorooctane sulfonate;perfluorooctanoic acid;Placenta;Poly-fluoroalkyl substances;Population;Positioning Attribute;Predisposition;Pregnant Women;Process;Public Health;pulmonary function;pyroglyphid;Race;Randomized;Reaction;Reporting;Research;Research Personnel;Resistance;Resources;respiratory health;Respiratory physiology;Respiratory System;Risk;Risk Factors;Role;Serum;sex;skills;skin prick test;Stains;symposium;Systems Development;Textiles;Time;Training;Translating;United States National Institutes of Health;urban area;urban children;Vulnerable Populations;Water;Wheezing;Work

PROJECT_TITLE: Associations between Perfluoroalkyl Substances (PFAS) Exposure and Aeroallergen Sensitization among Infants at High-Risk for Developing Asthma

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-O (O3)]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Alzheimer’s disease and related dementias (ADRD) is a public health priority and is well-established as a health disparity for some racial and ethnically minoritized groups. Transgender and gender diverse (TGD) people (i.e., those with a gender identity that differs from their sex assigned at birth) are a marginalized group that share many of the same psychosocial stressors and adverse health conditions linked to ADRD risk among cisgender adults (i.e., non-TGD) from minoritized ethnoracial communities; yet little is understood about the epidemiology and risk of ADRD among TGD adults. This proposal will determine the extent of ADRD disparities and ADRD risk among TGD adults, characterize TGD-specific experiences (e.g., TGD status disclosure) and psychosocial stressors (e.g., anti-TGD discrimination, social isolation) expected to influence cognition, and explore associations between cognitive function, TGD psychosocial stressors, and ADRD risk and protective factors among a cohort of middle-aged and older TGD adults.

PI_NAMEs: CICERO, ETHAN COLLIN (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Address;Adult;Affect;age stratification;aged;Aging;Alzheimer's disease related dementia;Alzheimer's disease risk;Birth;brain health;cardiometabolism;Cardiovascular Diseases;cisgender;clinical practice;Clinical Research;Cognition;Cognitive aging;cognitive function;cohort;Communities;community engaged research;Data;Data Analyses;Data Collection;Dementia;dementia risk;Disclosure;Discrimination;Disparity;early onset;Education;Electronic Health Record;Epidemiology;Equity;ethnic minority population;Ethnic Origin;ethnoracial minority;experience;Future;Gender;gender affirming hormone therapy;gender difference;gender diverse;Gender Identity;Goals;Health;health disparity;High Prevalence;human old age (65+);Impaired cognition;Incidence;Inequity;intersectionality;Interview;Knowledge;Life;life history;Link;longitudinal analysis;marginalized population;Measures;Medicare claim;member;Memory;Mental Depression;Mentored Patient-Oriented Research Career Development Award;middle age;Morbidity - disease rate;nonbinary;older adult;Outcome;Participant;Performance;Persons;pilot test;Population;Prevalence;Process;Prospective, cohort study;protective factors;Protocols documentation;prototype;psychosocial;psychosocial stressors;public health priorities;Qualitative Methods;Race;racial minority population;Research;Research Methodology;Research Personnel;research study;Risk;Sampling;sex assigned;skills;social;Social isolation;Statistical Methods;Structure;Subgroup;Testing;Training;transfeminine;transgender;transmasculine

PROJECT_TITLE: The Brain Health of Transgender and Gender Diverse Adults: An Examination of Alzheimer’s Disease and Related Dementias Risk and Psychosocial Stressors

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Lymphatic Research;Lymphedema;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Wound Healing and Care

PHR: PROJECT NARRATIVE Dysfunction of lymphatic vessels can lead to lymphedema and no-healing ulcers, affecting over 250 million people worldwide. Here I propose to examine the role of repair and immune-modulatory functions of lymphatic vessels in the control of wound repair to further our understanding of the cellular and molecular factors that underlie this complex process. My studies will uncover novel targets aimed at modulating lymphatic vessels, immune cells, and epidermal stem cells to advance therapeutic approaches in pathological tissue repair.

PI_NAMEs: KONIECZNY, PIOTR  (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Address;Affect;Behavior;Biology;Blood;Blood capillaries;career;career development;Cells;Chronic;chronic ulcer;chronic wound;Clinical;Communication;Complement Factor D;Complex;cytokine;Data;Dermal;Dermis;Development Plans;Drainage procedure;epidermal stem cell;Epidermis;epithelial repair;epithelial wound;Epithelium;experimental study;Fibroblasts;Fibrosis;fluid flow;Foundations;Future;Gene Expression;Genomics;Grant;Growth;Growth Factor;Hair follicle structure;healing;Human body;Image;Immune;immune cell infiltrate;immune function;Immune response;Immunologic Surveillance;immunoregulation;Impaired healing;improved;Inflammation;Injury;innovation;Intercellular Fluid;interstitial;Knowledge;Link;Liquid substance;Lymph;Lymphangiogenesis;Lymphatic;lymphatic circulation;lymphatic drainage;lymphatic dysfunction;Lymphatic function;Lymphatic System;lymphatic vessel;Lymphedema;Macrophage;Mediating;Medical;Mentors;Modeling;Molecular;morphogens;mouse model;multidisciplinary;Mus;Natural regeneration;non-healing wounds;novel;novel therapeutics;Pathologic;Patients;Peptides;Persons;Phase;Physiological;Physiology;Positioning Attribute;pressure;Prevalence;Process;Production;Productivity;programs;Proteins;re-epithelialization;recruit;regeneration function;Regulation;repaired;Research;research and development;Research Personnel;response;restoration;Role;single-cell RNA sequencing;Skin;Skin repair;skin wound;Source;stem cells;Swelling;Technology;Testing;Therapeutic;tissue repair;Tissues;tool;Ulcer;Vascular Endothelial Growth Factor C;Vascular Endothelial Growth Factor D;Vascular System;wound;wound closure;wound healing;wound treatment;Writing

PROJECT_TITLE: Decoding the repair and immunomodulatory functions of lymphatic vessels in wound healing

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative: The proportions and patterning of photoreceptor subtypes in the retina generate many primate-specific features of vision, including trichromatic color vision and high-acuity spatial vision. Disruption of photoreceptor specification results in disorders causing blindness. To unravel the temporal signaling mechanisms that specify primate photoreceptors, I will compare development in human and marmoset retinal organoids, "mini retinas" grown from primate stem cells.

PI_NAMEs: HAGEN, JOANNA FRANCES DONNELLY (contact)

PROJECT_TERMS: Address;Affect;Age related macular degeneration;Birth Order;Blindness;Callithrix;Callithrix jacchus jacchus;candidate validation;cell fate specification;Cells;Color;Color blindness;Color Visions;Communities;comparative;Cone;cone-rod dystrophy;CRISPR/Cas technology;data integration;Date of birth;Development;Developmental Biology;differential expression;Disease;Environment;experimental study;Generations;Genes;Genetic;Goals;hormonal signals;Human;Human Development;in vivo;Knock-out;Laboratory Finding;Light;Mammals;Mediating;Mentors;Modeling;Molecular;multiple omics;Neurons;nucleoside analog;Opsin;Organoids;Pattern;pharmacologic;Phase;Photophobia;Photoreceptors;primate development;Primate Diseases;Primates;Proteins;Protocols documentation;Regulatory Element;Retina;Retinitis Pigmentosa;rho;Rhodopsin;RNA;Rod;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;spatial vision;Specific qualifier value;stem cell organoids;stem cells;Technology;Testing;Thyroid Hormones;Time;timeline;Training;Tretinoin;Universities;Vertebrates;Vision;Vision Disorders;Visual

PROJECT_TITLE: Comparative analysis of photoreceptor developmental mechanisms in retinal organoids


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences

PHR: Project Narrative  Amyloids are a hallmark of neurodegenerative diseases and systemic amyloidoses. The examination of patient-derived amyloid structures reveals a correlation between the amyloid assembly and clinicopathology, but the role of amyloids in these illnesses is still largely unknown. The capability to design proteins that exhibit specific epitopes of amyloids would allow for the identification of pathological biomarkers and the development of effective treatments.

PI_NAMEs: YANG, HYUNJUN  (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: 3-Dimensional;Adopted;alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;Amino Acids;Amyloid;Amyloid beta-Protein;amyloid formation;Amyloid Proteins;amyloid structure;Amyloidosis;Area;Award;beta pleated sheet;Binding;Biochemical;Biochemistry;Biological Assay;Biological Markers;biomarker identification;Biophysics;Brain;catalyst;Cell model;Cells;Characteristics;computerized tools;Cryoelectron Microscopy;Crystallization;Deposition;design;design verification;Development;Disease;drug development;Drug Screening;effective therapy;Epitopes;Event;Exhibits;Fluorescence;Frontotemporal Dementia;Goals;Human;Immunohistochemistry;In Situ;In Vitro;innovation;Laboratories;Learning;Lesion;Libraries;Ligands;macromolecule;Mammalian Cell;Maps;Mediating;Metabolism;Methods;Microglia;Microscopic;Molecular;Molecular Conformation;molecular dynamics;Monoclonal Antibodies;monomer;mouse model;Negative Staining;Neurodegenerative Disorders;neuropathology;Neurosciences;overexpression;Pathogenesis;Pathologic;Patients;polyclonal antibody;Production;Protein Engineering;protein TDP-43;Proteins;receptor;Resolution;Role;Sampling;screening;small molecule;small molecule libraries;Solubility;Solvents;Structure;Study models;Sulfhydryl Compounds;Surface;targeted treatment;tau conformation;tau Proteins;Tauopathies;therapeutic target;tool;Transfection;TREM2 gene;Vertebral column;X-Ray Crystallography

PROJECT_TITLE: Patching Amyloid Surface onto Soluble Protein

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: Genetic studies involving thousands of individuals have identified many genes associated with glaucoma risk, though this has not yet translated to personalized approaches for diagnosis, monitoring or treatment of this common, blinding disease. This mentored clinician-scientist career development proposal will investigate the clinical impact and underlying disease mechanisms for glaucoma-associated genes that function in the mitochondria, the energy-producing parts of our cells. The approach is designed to help pave the way for personalized glaucoma care for individuals whose disease is driven by mitochondrial gene variants; the methodologies employed in this proposal can also be readily applied to other genes and pathways in the future to lay the foundation for precision glaucoma care.

PI_NAMEs: ABOOBAKAR, INAS F. (contact)

PROJECT_TERMS: Affect;Age;Antioxidants;aqueous;archetypal analysis;Axon;biobank;Bioinformatics;Blindness;Blood Vessels;career;career development;Caring;Cell Physiology;Cells;Clinic;Clinical;clinical care;Clinical Data;clinical phenotype;Clinical Research;Code;common treatment;Communities;Consumption;Cytoprotection;Data;Data Science;Databases;design;Development;Development Plans;Devices;Diagnosis;Disease;disease diagnosis;disorder subtype;Ear;Environment;Environmental Risk Factor;ex vivo perfusion;Exercise;Extracellular Matrix;Eye;Fellowship;Follow-Up Studies;Foundations;Functional disorder;Funding;Future;Gene Combinations;gene function;Genes;Genetic;Genetic Risk;Genetic study;genetic variant;genome wide association study;genomic locus;Glaucoma;Glutathione;Goals;Health Professional;high intraocular pressure;Homeostasis;Human;human stem cell-derived;Hydrogen Peroxide;Image;Impairment;improved;In Vitro;Individual;Injury;Intake;knock-down;Life Style;malic enzyme;Measures;member;Membrane Potentials;Mentors;Mentorship;Meta-Analysis;Methodology;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Modeling;Molecular;Monitor;Morphology;NADP;neuroprotection;Niacinamide;Nicotinic Acids;Nurses' Health Study;Optic Disk;overexpression;Oxidation-Reduction;oxidative damage;Pathogenesis;Pathogenicity;Pathway interactions;Patient Recruitments;Patients;Pattern;Peripheral;personalized approach;Physiologic Intraocular Pressure;polygenic risk score;Population;precision medicine;Precision Medicine Initiative;Predisposition;Prevalence;Prevention;Primary Open Angle Glaucoma;Production;Reactive Oxygen Species;Research;Research Design;Research Personnel;Resources;response;Retina;Retinal Ganglion Cells;Risk;Risk Factors;risk stratification;risk variant;Role;Scientist;Severity of illness;Signal Transduction;skills;Smoking;Superoxides;targeted treatment;Testing;thioredoxin reductase 2;Toxic Environmental Substances;Trabecular meshwork structure;Training Programs;Transforming Growth Factor beta;Translating;United States National Institutes of Health;Variant;Visual Fields;Work

PROJECT_TITLE: Clinical and functional assessment of glaucoma-associated mitochondrial gene variants to facilitate precision eye care

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (04)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biomedical Imaging;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Physical Injury - Accidents and Adverse Effects;Social Determinants of Health;Violence Research;Youth Violence

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE  Bruising in young children is a frequent indicator of physical abuse and can have significant medical, legal and social consequences if identified. It is vital that we have an objective means of identifying bruises in children, as doing so can impact proper healthcare utilization, diminish unnecessary child welfare investigations, and minimize racial disparities in medical, social (i.e., child welfare) and legal invesigations.

PI_NAMEs: NARANG, SANDEEP  (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: absorption;Abuse Reporting;Acceleration;Affect;Age;Appearance;Area;Arteriovenous malformation;Benign;Bilirubin;Biliverdine;Blood;blood product;Blood Vessels;Cellular Phone;Cessation of life;Characteristics;Child;Child Abuse and Neglect;child physical abuse;child protective service;Child Welfare;Childhood;chromophore;Clinical;Clinical assessments;clinical practice;Clinical Research;Color;Color Perception;Contusions;Data;Data Set;deoxyhemoglobin;Dermal;Dermatologic;Development;Diagnosis;Diagnostic;diagnostic tool;diffuse reflectance spectroscopy;Disadvantaged;Enrollment;Ensure;Evaluation;Evolution;Extravasation;Forensic Medicine;Goals;health care service utilization;Hemoglobin;high risk infant;Human;Hyperpigmentation;imaging modality;Individual;Infant;Inflammation;Inflammatory;Injury;innovation;Interpersonal Violence;Investigation;Laboratories;Least-Squares Analysis;Legal;Lesion;Light;machine learning algorithm;Magnetic Resonance Imaging;malformation;Measures;Medical;medical attention;Medical Research;Melanins;Melanoma;Metabolic;Methemoglobin;Methods;Modeling;Mongolian Spot;Monte Carlo Method;Morbidity - disease rate;Neonatal Jaundice;novel;Optics;Outcome;Painless;patient population;Patients;Pattern;Pediatric Hospitals;physical abuse;Play;point of care;prediction algorithm;predictive modeling;Process;prospective;Prospective Studies;Race;racial disparity;recruit;Reporting;Roentgen Rays;Sensitivity and Specificity;Sentinel;Severities;Signal Transduction;Skin;skin discoloration;social;Spectrum Analysis;standard of care;stem;Survivors;Technology;Time;tool;United States National Institutes of Health;Vasculitis;Visible Radiation;Visual

PROJECT_TITLE: The Objective Identification of Bruising in Children using Diffuse Reflectance Spectroscopy

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Genetics;Precision Medicine

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Ankylosing Spondylitis (AS) causes decreased physical functioning and disability due to aberrant bone formation and damage of the spine. In this proposal we will develop tools that can help prognosticate AS patients’ risk of severe spinal disease through molecular profiling and biomarker identification. Furthermore, the results will provide a foundation for studies investigating the pathophysiology of AS spinal disease and enhance recruitment in clinical trials studying treatments for this disease-specific outcome.

PI_NAMEs: HWANG, MARK CHIAWEI (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Acceleration;Affect;Ankylosing spondylitis;Applications Grants;Award;Bioinformatics;bioinformatics tool;Biological Markers;biomarker identification;Blood Cells;bone metabolism;career development;cell type;Cells;Chronic;Clinical;clinical biomarkers;clinical care;Clinical Data;Clinical Markers;clinical phenotype;clinical predictors;Clinical Trials;cohort;Collection;Data;Data Set;design;Development;disability;Disease;Disease Progression;DNA;effective therapy;Environment;Foundations;Functional disorder;Funding;Future;Gene Expression;Gene Expression Profile;Genetic;genetic signature;Goals;Grant;Heterogeneity;Hyperostosis;Immune;Immunology;improved;Inflammation;Inflammatory Arthritis;Infrastructure;Institution;Instruction;Interferon Type II;Knowledge;Longitudinal Studies;Medicine;Mentors;Mentorship;Methodology;Modeling;Molecular;Molecular Analysis;molecular marker;molecular phenotype;Molecular Profiling;Monitor;monocyte;Morbidity - disease rate;next generation;novel;Observational Study;Osteogenesis;Outcome;Outcome Study;Pathogenesis;Patient risk;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;personalized approach;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Physical Function;physically handicapped;Population;predictive modeling;predictive tools;Preparation;Productivity;Prognosis;Prognostic Marker;prognostic model;prognostic signature;prognostication;programs;prospective;Prospective Studies;Proteins;Proteomics;radiological imaging;recruit;Research;Research Design;Research Personnel;Resources;rheumatologist;RNA;Sacroiliac joint structure;Sampling;Scientist;Severities;Severity of illness;single-cell RNA sequencing;skills;Spinal;Spinal Diseases;Spinal Fusion;spine bone structure;Spondylarthritis;System;Systemic Scleroderma;T-Lymphocyte;Technology;tool;Training;Transcript;transcriptome sequencing;transcriptomics;Translational Research;treatment strategy;United States National Institutes of Health;Validation;Vertebral column;Work;Writing

PROJECT_TITLE: Molecular Profiling of Spinal Disease Progression in Ankylosing Spondylitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZAR1 FY (M1)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Muscular Dystrophy;Neurosciences;Rare Diseases

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE With clinically-available genetic testing, the majority of patients with suspected monogenic muscle diseases lack a genetic diagnosis which impedes medical management. The goal of this project is to develop best practices for combined analysis of genome (DNA), transcriptome (RNA), and proteome (protein) research technologies to identify novel variants and genes and improve the diagnostic yield for patients with muscle disease.

PI_NAMEs: GANESH, VIJAY S (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Address;Adult;Affect;artificial neural network;autoencoder;Biopsy;Boston;career development;Clinical;clinical diagnosis;clinical sequencing;clinical training;Code;cohort;collaborative environment;Collagen Type VI;Complement;congenital muscular dystrophy;Development;Diagnosis;Diagnostic;Diagnostic tests;disability;Disease;disease-causing mutation;DNA;DNA Methylation;Etiology;Evaluation;Exons;Facioscapulohumeral Muscular Dystrophy;Fibroblasts;gene discovery;Gene Expression;gene-targeted therapy;Genes;genetic architecture;genetic disorder diagnosis;genetic testing;Genetic Transcription;genome analysis;genome sequencing;Goals;Histologic;Hospitals;Human Genome;improved;in silico;Individual;insertion/deletion mutation;Label;Lead;Limb structure;loss of function;Loss of Heterozygosity;Medical;Medical Genetics;medical schools;Medicine;Mentors;Methods;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;Molecular Diagnosis;molecular diagnostics;mortality;multiple omics;Muscle;Myopathy;Myotonic Dystrophy;Nervous System Disorder;neuromuscular;novel;Pathogenicity;Pathologic;patient oriented research;Patients;Pediatric Hospitals;Physicians;Positioning Attribute;Prevalence;protein expression;Protein Isoforms;Proteins;Proteome;Proteomics;Rare Diseases;real world application;Research;research and development;research clinical testing;Resolution;RNA;RNA Splicing;Scientist;Short Tandem Repeat;Single Nucleotide Polymorphism;skills;Somatic Mutation;Syndrome;Tandem Repeat Sequences;Technology;Testing;Tissues;tool;Training;transcriptome;transcriptome sequencing;Translational Research;United States National Institutes of Health;Untranslated RNA;Variant;variant of unknown significance;Whole Blood;Woman;Work

PROJECT_TITLE: Integrating multiomic analyses for gene discovery andgenetic diagnosis of Mendelian myopathies


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: CHICAGO

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE  Appropriately responding to environmental perturbations is key to proper genome function, but how genetic variation affects these responses is poorly understood. This project uses comparative genomic approaches to understand the gene regulatory mechanisms underlying variation in the response to immune stimulation (a well understood environmental perturbation) among humans and other primates. The results will yield a detailed molecular understanding of gene-by-environment interactions across cell types, conditions, and species, providing insight into the mechanisms shaping complex traits, genome function, and human health.

PI_NAMEs: VILGALYS, TAURAS P (contact)

PROGRAM_OFFICER_NAME: WETTERSTRAND, KRIS A

PROJECT_TERMS: Affect;antagonist;Atlases;Automobile Driving;Bacteria;Biological Assay;Biological Process;Biological Response Modifiers;Biology;Blood Cells;career;causal variant;cell type;Cells;Chromatin;Chromosome Mapping;Communicable Diseases;comparative;comparative genomics;Comparative Study;Complex;Data;Disease;Disease susceptibility;Double Stranded RNA Virus;Enhancers;Environment;Environmental Risk Factor;Evolution;experience;experimental study;Faculty;gene environment interaction;Gene Expression;Genes;Genetic;genetic approach;Genetic Transcription;genetic variant;Genetic Variation;Genome;Genomic approach;Genomics;Grain;Gram-Negative Bacteria;Health;health difference;Human;Immune;immune function;Immune response;Immune system;Immunologic Stimulation;Immunologics;Immunology;improved;in vitro Assay;in vivo;Individual;Infection;Infectious Agent;insight;interest;Light;Link;Mediating;Mentors;Modeling;Molecular;Mutation;Natural Selections;nonhuman primate;novel;Nucleic Acid Regulatory Sequences;Organism;parallelization;pathogen;Pathway interactions;Peripheral Blood Mononuclear Cell;Play;Population Genetics;Predisposition;Primates;Process;Regulatory Element;Reporter;Research;Research Design;response;Role;Sampling;Severities;Severity of illness;Shapes;single cell ATAC-seq;single cell sequencing;single-cell RNA sequencing;Stimulus;System;time use;Tissues;TLR3 gene;TLR4 gene;Training;trait;transcription factor;transcriptomics;Variant;Virus;Work

PROJECT_TITLE: Genomic basis of variation in the transcriptional response to pathogens among primates

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Obligately intracellular tick-borne disease agents, those that can only replicate inside a vertebrate or tick host cell, are a severe and growing threat to human and animal health world-wide. Studying gene function of bacterial pathogens using mutational analysis in which genes are inactivated by insertion of an interruptive sequence such as a transposon, is an important step towards designing treatments and preventive strategies such as vaccines, but this approach has been very difficult to implement with obligately intracellular bacteria, including those transmitted by ticks. We have pioneered large-scale mutagenesis of tick-borne Anaplasma phagocytophilum in human cells, demonstrated that mutant Rickettsia parkeri are safe and effective vaccinogens, and we now propose to expand on these previous achievements by generating a library of A. phagocytophilum mutants in which the function of mutated genes can be easily restored to verify mutant and wild-type phenotypes, and to test the effect of mutations on mouse infectivity and tick transmissibility.

PI_NAMEs: OLIVER, JONATHAN D (contact)

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: Achievement;Adopted;Affect;Algorithms;Alleles;Anaplasma;Anaplasma phagocytophilum;Anaplasmosis;Animals;Antibodies;Arthropod Vectors;Award;Bacteria;Bar Codes;Bioinformatics;Cattle;Cell Culture Techniques;Cell Line;Cells;Climate;Collection;Communities;Coupled;Cre lox recombination system;Cre-LoxP;Culicidae;Databases;design;Dideoxy Chain Termination DNA Sequencing;Disease;DNA;Ehrlichia;Ehrlichia chaffeensis;Ehrlichiosis;Enterobacteria phage P1 Cre recombinase;Gene Expression Profile;gene function;gene product;Gene Proteins;Generations;Genes;Genetic;genetic manipulation;Genetic Transcription;Genome;genome sequencing;Global Change;Health;HL60;Human;human pathogen;Immunology procedure;In Vitro;in vivo;Infection;interest;Knock-in;knockout gene;Laboratories;Libraries;Life;Life Cycle Stages;Link;LoxP-flanked allele;Mammalian Cell;Mediating;Modeling;Molecular;Molecular and Cellular Biology;monocyte;Movement;Mus;Mutagenesis;mutant;Mutate;Mutation;Mutation Analysis;Organism;pathogen;pathogenic bacteria;Pharmaceutical Preparations;Phase;Phenotype;Population;Prevention strategy;Reaction;recombinase-mediated cassette exchange;Reporting;Reproducibility;restoration;Reverse Transcriptase Polymerase Chain Reaction;Rickettsia;Rickettsia parkeri;Rickettsia rickettsii;RNA;Rocky Mountain Spotted Fever;Shuttle Vectors;Site;success;System;Techniques;Testing;therapy design;therapy development;tick transmission;tick-borne;Tick-Borne Diseases;tick-borne pathogen;Ticks;Time;tissue tropism;Transcript;Translations;transmission process;Transposase;treatment strategy;uptake;Vaccines;vector tick;Vector-transmitted infectious disease;whole genome

PROJECT_TITLE: Reversible transformation of Anaplasma phagocytophilum using Cre-Lox recombination

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 FDS-M (S1)]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Nutrition;Pancreatic Cancer;Rare Diseases

ORG_CITY: Columbus

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE The hexosamine biosynthetic pathway synthesizes UDP-GlcNAc that is necessary for a wide range of glycosylation reactions, and inhibition of this pathway has shown promise as anti-cancer treatment. We propose to identify how the hexosamine pathway promotes the storage of lipids within tumor cells and evaluate if simultaneous inhibition of hexosamine biosynthesis and lipid metabolism improves therapeutic outcomes.

PI_NAMEs: PAPANDREOU, IOANNA  (contact)

PROJECT_TERMS: Ablation;Acceleration;Anabolism;anti-cancer treatment;Apoptosis;Cancer Model;cancer therapy;CASP3 gene;Cd68;CD8B1 gene;cell growth;Cell Physiology;Cell Proliferation;Cell Separation;Cells;Characteristics;Chemicals;Cholesterol;Cholesterol Esters;Communication;deprivation;detection of nutrient;diacylglycerol O-acyltransferase;Engineering;Ensure;Equilibrium;Esterification;Event;Fatty Acids;Fructose;fructose-6-phosphate;Gene Expression;Genetic;genome wide screen;genome-wide;Glutamine;glycosylation;Growth;Hexosamines;Homeostasis;Hypoxia;Immune;immune cell infiltrate;improved;improved outcome;In Vitro;in vitro Model;in vivo;inhibitor;Investigation;knock-down;Link;lipid biosynthesis;lipid metabolism;Lipids;Lipolysis;liquid chromatography mass spectrometry;loss of function;macromolecule;Malignant - descriptor;Malignant Neoplasms;Measures;membrane synthesis;Metabolic;Metabolism;Modeling;Mus;mutant;neoplastic cell;normoxia;novel;Nutrient;Nutrient availability;Nutritional;Nutritional Requirements;Oncogenic;Organelles;Output;oxidation;Oxygen;Pancreatic Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Population;Post-Translational Protein Processing;pre-clinical;Pre-Clinical Model;preclinical development;programs;Proliferation Marker;Protein Glycosylation;protein transport;Reaction;Scheme;sensor;Signal Transduction;Small Interfering RNA;small molecule;Stress;success;targeted treatment;Therapeutic;therapeutic development;therapy outcome;Toxic effect;Transaminases;treatment strategy;Triglycerides;tumor;Tumor Cell Line;tumor growth;uptake;Uridine;Withdrawal

PROJECT_TITLE: Exploring the interaction of lipid metabolism with the hexosamine pathway and tumor growth

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-F (O1)]


ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: The efficacy and durability of anti-tumor immunity and immunotherapies for cancer are limited by insufficient development of memory CD4+T cells, which mediate immunological memory and maintain immune responses. Although safe and effective methods to increase memory CD4+T cells have been lacking, we recently discovered that oral administration of the dietary sugar L-fucose increases anti-tumor immunity and the abundance of memory CD4+T cells inside melanomas, suppressing tumor growth and enhancing durable responses to immune checkpoint blockade. In this application, we propose to delineate the underlying molecular mechanism(s) and test how L-fucose may enhance immunological memory and suppress tumor recurrence.

PI_NAMEs: LAU, ERIC KIRK (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Adoptive Cell Transfers;anti-melanoma immunity;anti-PD-1;anti-tumor immune response;Biological;Biological Assay;Biology;cancer immunotherapy;CD4 Positive T Lymphocytes;Cell surface;Cellular biology;Clinical;Combination immunotherapy;Combined Modality Therapy;cytotoxic;Data;Development;Dietary Sugars;Effector Cell;Excision;exhaustion;fitness;Fucose;Gene set enrichment analysis;gene therapy;glycosylation;HLA-DRB1;Human;Immune;immune checkpoint blockade;Immune response;Immunocompetent;Immunologic Memory;Immunologics;Immunotherapy;in vivo;Infection;Infusion procedures;knock-down;knowledge translation;Maintenance;Malignant Neoplasms;Mediating;Mediator;Medicine;Melanoma;Melanoma Cell;Melanoma patient;Memory;memory CD4 T lymphocyte;Methods;Microarray Analysis;Modeling;Molecular;mouse model;Mus;Nature;neoplasm immunotherapy;novel strategies;Oncogenes;Oral;Oral Administration;Pathologic;Pathway Analysis;Pathway interactions;patient response;patient subsets;Patients;Phenotype;Plants;Play;Population;Primary Neoplasm;Proteins;Recurrence;Recurrent tumor;response;Role;self-renewal;Signal Transduction;single-cell RNA sequencing;Sorting;Stains;sugar;survival outcome;T cell receptor repertoire sequencing;T memory cell;T-Lymphocyte;targeted agent;Testing;translational potential;tumor;tumor growth;Tumor Immunity;Tumor Suppression;Tumor Tissue;Tumor-Derived;Tumor-infiltrating immune cells;Validation

PROJECT_TITLE: L-fucose-mediated enrichment of memory CD4+T cells and enhanced anti-melanoma immunity


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Pregnancy

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE The current project aims to delineate how neural circuits change before and immediately following birth, corresponding to rapid formative growth and transition from the womb to a sensory-abundant world. We will also explore how preterm birth and maternal inflammation may interact with maturational processes during this time. This work holds the potential to uncover novel mechanisms underlying common disorders of early human development, which may, in turn, inform development of new, biologically-informed, targeted therapeutic interventions.

PI_NAMEs: JI, LANXIN  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Address;Affect;Age;Architecture;Award;Beginning of Life;Behavior;Behavior assessment;behavioral outcome;biobehavior;Birth;Blood;Brain;brain based;Brain imaging;career;career development;Child;Chronology;Clinical;Clinical Research;cognitive neuroscience;Complex;computational neuroscience;computerized data processing;connectome;Data;Data Collection;Data Set;deep learning;deep learning model;Development;Development Plans;Diffusion Magnetic Resonance Imaging;Disease;Documentation;Educational Status;Environment;experience;fetal;Functional Magnetic Resonance Imaging;functional MRI scan;Future;Goals;Graph;Growth;healthy volunteer;high risk;High-Risk Pregnancy;Human;Human Development;Image;immune activation;indexing;Individual;individual variation;Infant;infant outcome;Inflammation;innovation;insight;interest;Knowledge;knowledge base;Life;Linear Models;Link;Literature;longitudinal dataset;Magnetic Resonance Imaging;Maps;maternal risk;Measurement;Mediating;Medical;Mentorship;Methodology;Methods;Modeling;Motor;multimodality;Neonatal;neonatal period;neural circuit;neurobiological mechanism;neuroimaging;Neuropsychology;Neurosciences;Neurosciences Research;Non-linear Models;novel;Outcome;Pathway Analysis;Pattern;Perinatal;Phase;Play;postnatal;Pregnancy;premature;Premature Birth;Premature Infant;Preparation;Prevention strategy;Process;Public Health;quality assurance;Research;Research Personnel;Research Project Grants;Role;Sampling;Sensory;skills;Statistical Models;System;targeted treatment;Technical Expertise;Techniques;Testing;Therapeutic Intervention;therapy development;Time;tool;Training;treatment strategy;Uterus;Work

PROJECT_TITLE: Longitudinal assessment of human brain connectome changes across the birth transition in both term and preterm pregnancies

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Biobehavioral and Behavioral Sciences Study Section[CHHD-H]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: NARRATIVE  Use of multiple tobacco products is becoming increasingly prevalent in the United States, with dual use of cigarettes and e-cigarettes representing the most common combination. The Food and Drug Administration Center for Tobacco Products has announced plans to implement a nicotine-limiting product standard for cigarettes and policy makers at the state and federal levels have proposed limiting the amount of nicotine in e- cigarettes. We propose a 12-week double-blind randomized controlled trial to investigate how a nicotine-limiting standard for cigarettes affects smoking among adult dual users and whether these effects are impacted by constraints on e-cigarette nicotine content.

PI_NAMEs: KLEMPERER, ELIAS M (contact)

PROGRAM_OFFICER_NAME: KAUTZ, MARY A

PROJECT_TERMS: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol;Abstinence;addiction;Address;Adult;Affect;Agreement;Behavior;Blood;Carbon Monoxide;Carcinogen exposure;Chronic;Cigarette;cigarette smoke;Cigarette Smoker;cigarette smoking;Controlled Study;Dependence;design;Double-Blind Method;Electronic cigarette;electronic cigarette use;electronic cigarette user;electronic liquid;Exclusion;Goals;Health;innovation;Laboratories;Laboratory Study;liquid nicotine;low nicotine content cigarette;Modeling;Morbidity - disease rate;mortality;next generation;Nicotine;Nicotine Dependence;Outcome;Outcome Measure;Participant;Policies;Policy Maker;Population;pressure;Public Health;Randomized;Randomized, Controlled Trials;Research;Risk;Risk Reduction;Smoke;Smoker;Smoking;smoking abstinence;smoking addiction;Sodium Chloride;Testing;Tobacco;tobacco products;tobacco user;Toxicant exposure;United States;United States Food and Drug Administration;Visit;Weight;Youth

PROJECT_TITLE: A randomized controlled trial of reduced nicotine cigarettes and e-cigarettes among dual users

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-X (56)]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: LEXINGTON

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Helicobacter pylori chronically colonizes the stomach of more than half of the global population and is the strongest known risk factor for the development of gastric cancer. The proposed studies will explore the mechanisms by which H. pylori delivers microbial DNA into gastric cells trigger innate immune signaling. These investigations will advance our understanding of how an important bacterial carcinogen regulates host immunity to promote chronic inflammation and stimulate the development of stomach malignancies.

PI_NAMEs: SHAFFER, CARRIE  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Address;Bacteria;Biochemical;Biological;Biological Assay;Biology;Cancer Biology;carcinogenesis;carcinogenicity;Carcinogens;Cells;Chronic;Coupled;cytokine;Data;Development;Devices;Disease Outcome;DNA;DNA delivery;DNA relaxase;endonuclease;Eukaryotic Cell;Future;Gastritis;Goals;Helicobacter Infections;Helicobacter pylori;Human;Immune response;Immune signaling;Immunity;Immunologic Surveillance;Immunology procedure;in vivo;Incidence;Infection;infection related cancer;Inflammation;Inflammatory;innovation;Interferons;Intervention;Investigation;Isomerism;Kinetics;Knowledge;Lesion;Malignant Neoplasms;malignant stomach neoplasm;Mediating;Microbe;microbial;Microscopy;Modeling;Molecular;mouse model;nanomachine;novel therapeutic intervention;Nucleic Acids;Oncogenic;Oncoproteins;Orthologous Gene;Outcome;pathogen;Pathway interactions;Polysaccharides;Population;premalignant;Production;Proteins;Reporter;Research;Resolution;Risk Factors;Rodent;Role;secretion process;segregation;Severities;Signal Transduction;Stomach;Stomach Diseases;System;translational study;transposon/insertion element;tumorigenesis;Type IV Secretion System Pathway;Virus;Work

PROJECT_TITLE: Molecular mechanisms of Helicobacter pylori trans-kingdom DNA conjugation

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Kidney Disease;Pediatric;Physical Activity;Prevention

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

PHR: Project Narrative: Young people with chronic kidney disease (CKD) have a high lifetime risk for cardiovascular disease, including heart failure with preserved ejection fraction (HFpEF). However, youth with CKD have been largely excluded from studies that improve detection of HFpEF at the earliest stages and from trials of medications that prevent heart disease in adults with CKD. This study will leverage insights developed in adults with CKD to better define early and subtle changes in heart function in youth with CKD and to begin to test the reversibility of these changes using an interventional study.

PI_NAMEs: KULA, ALEXANDER JAMES (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: 18 year old;Address;Adolescent;Adult;Advisory Committees;Age;aged;Albuminuria;Area;arm;Blood Pressure;Cardiac;cardioprotection;Cardiopulmonary;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;career development;Cause of Death;Chicago;Child;Childhood;Chronic Kidney Failure;Clinic;Clinical;clinical phenotype;Clinical Trials;Clinical Trials Design;cohort;Collaborations;Committee Members;Complication;Consent;Data;design;Detection;Development;Development Plans;Disease;Echocardiography;EFRAC;Ensure;Environment;Exclusion;Exclusion Criteria;Exercise;exercise capacity;Exercise Test;experience;Feasibility Studies;Functional disorder;Future;Glucose;Goals;Heart Atrium;heart disease prevention;Heart failure;heart function;high risk;Image;Impairment;improved;Incentives;inclusion criteria;Individual;inhibitor;innovation;insight;Institution;Intervention;Intervention Studies;Knowledge;Learning;Left;lifetime risk;Measures;medical schools;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Monitor;multidisciplinary;Myocardial;Nephrology;open label;Parents;Participant;participant enrollment;patient oriented research;Patient Recruitments;Patients;pediatric department;Pediatric Hospitals;pediatric patients;Persons;Pharmaceutical Preparations;Phenotype;Physicians;Physiological;pilot trial;Population;Positioning Attribute;preservation;prevent;primary endpoint;pro-brain natriuretic peptide (1-76);Procedures;professor;Qualifying;Questionnaires;Randomized;recruit;Research;Research Infrastructure;Research Institute;Research Methodology;Research Personnel;research study;response;Rest;retention rate;Risk;Risk Reduction;Safety;Schedule;Scientist;secondary analysis;secondary endpoint;sex;skills;Sodium;standard of care;Stress;Stress Echocardiography;symporter;Testing;Training;transition to adulthood;Universities;Visit;Youth

PROJECT_TITLE: Advancing the Approach to Subclinical Diastolic Dysfunction in Youth with Chronic Kidney Disease

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Pelvic Inflammatory Disease;Sexually Transmitted Infections;Urologic Diseases;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE This proposal focuses on Mycoplasma genitalium (MG), a sexually transmitted bacterium of men and women that is highly resistant to antibiotics. We recently discovered that MG is susceptible to nitroimidazole antibiotics, adding a possible new therapy to the short list of effective treatments. This study will identify which nitroimidazoles are most effective against MG, how these antibiotics kill MG, and how MG becomes resistant to these drugs.

PI_NAMEs: WOOD, GWENDOLYN  (contact)

PROGRAM_OFFICER_NAME: CONNOLLY, KRISTIE LEE

PROJECT_TERMS: 18 year old;Adolescent;Aerobic;Affect;Alleles;Anaerobic Bacteria;analog;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Antimicrobial Resistance;Awareness;Azithromycin;azithromycin resistance;Bacteria;bactericide;Biochemical;Ceftriaxone;Cell Death;Cell Wall;Cervicitis;Chlamydia trachomatis;Clinical;clinical efficacy;clinical predictors;Clinical Research;Clinical Trials;Collection;Data;Development;Diagnosis;Diagnostic tests;DNA Repair Gene;Dose;Doxycycline;Drug Metabolic Detoxication;Drug resistance;effective therapy;Effectiveness;efficacy evaluation;Endometritis;Endometrium;Enzyme Interaction;Enzymes;Female infertility;fitness;Flavin Mononucleotide;Fluoroquinolones;Future;Genetic;genome sequencing;Growth;Health;high risk;high risk population;Human;In Vitro;in vitro activity;Infection;Infertility;Kinetics;Laboratories;Literature;Macrolide-resistance;Macrolides;Measures;Membrane;men;men who have sex with men;Metronidazole;Microbial Biofilms;Minimum Inhibitory Concentration measurement;Molecular Mechanisms of Action;Moxifloxacin;mutant;Mutation;Mycoplasma;Mycoplasma genitalium;Neisseria gonorrhoeae;Nitrofurans;Nitroimidazoles;Nonspecific urethritis;novel therapeutics;Organism;Oxidoreductase;pathogen;pathogenic bacteria;Patients;Pelvic Inflammatory Disease;Peptidoglycan;Pharmaceutical Preparations;Population;Population Study;Predisposition;Pregnant Women;Premature Birth;Prevalence;Prodrugs;Proteins;Publishing;quinolone resistance;Recommendation;Reporting;reproductive tract;Resistance;resistance mechanism;resistance mutation;resistant strain;Role;Safety;Serum;Sexual Transmission;Sexually Transmitted Diseases;side effect;Syndrome;synergism;Time;Toxic effect;translational impact;treatment choice;Trichomonas vaginalis;Urethritis;whole genome;Woman;women's treatment;Wood material

PROJECT_TITLE: Nitroimidazole susceptibility and mechanisms of resistance in Mycoplasma genitalium

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AIRT-J (01)]


NIH_SPENDING_CATS: Asthma;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Primary Health Care;Social Determinants of Health

PHR: PROJECT NARRATIVE Asthma affects 25 million patients in the United States; however, the effects of asthma are inequitably experienced with asthma disproportionately burdening patients living in lower-resource communities. In this career development award, the candidate and his mentoring team will partner with a network of federally qualified health centers in St. Louis, Missouri to assess if the single maintenance and reliever therapy (SMART) implementation bundle improves providers’ prescription of guideline-recommend SMART (Aim 1, 1° effectiveness outcome) while concomitantly using the RE-AIM framework to evaluate implementation outcomes including adoption (Aim 2, 1° implementation outcome). The potential impact of this study is high for the scientific community, local community health centers, and the applicant as it provides the mentored training needed to prepare him to subsequently lead an R01-level hybrid effectiveness-implementation trial for guideline-recommend SMART therapy.

PI_NAMEs: KRINGS, JAMES  (contact)

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: Address;Adoption;Affect;American Lung Association;Area;Asthma;asthma exacerbation;asthmatic patient;Award;Black race;career;career development;Caring;Cessation of life;Cities;Clinic;Clinical;cluster randomized design;Cluster randomized trial;Communities;community academic partnership;community based participatory research;cost;Critical Care;design;Development Plans;didactic education;disadvantaged background;Education;Educational Status;effectiveness evaluation;effectiveness outcome;effectiveness/implementation trial;Electronics;Emergency Care;Emergency department visit;Equity;evidence base;experience;Faculty;Federally Qualified Health Center;Feedback;Fostering;Funding;Future;Goals;Guidelines;Health;health care disparity;Household;Hybrids;implementation evaluation;implementation framework;implementation outcomes;implementation science;improved;improved outcome;Individual;Inequity;Inhalators;innovation;Institution;K-Series Research Career Programs;Knowledge;Lead;long-standing disparities;low socioeconomic status;Lung;Maintenance;medical schools;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentors;Methodology;Missouri;National Heart, Lung, and Blood Institute;Neighborhood Health Center;Outcome;Outcome Assessment;patient oriented;Patient risk;Patients;Pattern;Persons;Physicians;Population;Prevention education;Prevention program;professor;programs;Provider;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Relative Risks;Research;Research Methodology;Research Personnel;Research Project Grants;Resource Development;Resource-limited setting;Respiratory Disease;Risk;Schools;Scientist;Supervision;tool;Training;United States;United States National Institutes of Health;Universities;Update;Washington;Work

PROJECT_TITLE: Implementation of SMART therapy for asthma patients in low-resource community health centers

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (OA)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cardiovascular;Heart Disease;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: Narrative It is imperative that less cardiotoxic drugs and drug combinations be developed for patients at highest risk of developing treatment-associated cardiomyopathy, especially children, adolescents, and young adults with sarcoma. This study will bring together experts in pediatric oncology and cardiology to address this need. The team will use innovative animal models to investigate novel cancer therapies that hold promise as effective but less cardiotoxic treatment regimens, focusing on combining epigenetic drugs with minimally cardiotoxic anthracyclines.

PI_NAMEs: LAWLOR, ELIZABETH R (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Acceleration;Address;Adolescence;Adolescent and Young Adult;Amino Acid Motifs;Animal Model;Anthracycline;Antineoplastic Agents;Bromodomain;Bromodomains and extra-terminal domain inhibitor;cancer therapy;Cardiology;Cardiomyopathies;Cardiotoxicity;Cause of Death;Cell Line;Child;childhood cancer survivor;Chronic;Clinical;clinical remission;Clinical Trials;Collaborations;Combination Drug Therapy;Combined Modality Therapy;Cytotoxic Chemotherapy;Data;Diagnosis;Dose;Doxorubicin;Drug Combinations;Drug Screening;Drug Targeting;early phase clinical trial;epigenetic drug;Epigenetic Process;epigenetic regulation;epigenome;Ewings sarcoma;Exposure to;Future;Gene Expression Regulation;Goals;Heart;high risk;Histone Deacetylase Inhibitor;histone methyltransferase;immunodeficiency;improved;in vivo;in vivo Model;innovation;Investigation;Investigational Drugs;Investigational Therapies;Knowledge;Libraries;Life Expectancy;Malignant Childhood Neoplasm;Modeling;multidisciplinary;Mus;Mutation;Normal tissue morphology;novel;Oncology;Outcome;Patients;Pediatric cardiology;Pediatric Oncology;Pharmaceutical Preparations;Pharmacotherapy;pre-clinical;Pre-Clinical Model;Quality of life;Recurrent disease;Regimen;Relapse;Safety;Sarcoma;screening;Screening procedure;small molecule;small molecule libraries;standard of care;synergism;Testing;Tissues;Translations;Treatment Protocols;tumor;Wild Type Mouse;Work;Xenograft Model;Xenograft procedure;Zebrafish

PROJECT_TITLE: Identifying non-cardiotoxic drug combinations for patients with relapsed sarcoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-P (O2)]


NIH_SPENDING_CATS: Aging;Autoimmune Disease;Biomedical Imaging;Brain Disorders;Clinical Research;Multiple Sclerosis;Neurodegenerative;Neurosciences;Prevention

PHR: PROJECT NARRATIVE Chronological age is the most important risk factor for disease progression in multiple sclerosis (MS), but the role of biological aging in MS is poorly understood. This proposed study aims to determine the associations of biological aging with outcomes and immune dysregulation in MS. Results linking accelerated biological aging to worse MS outcomes may lead to future studies using biological age as a predictive biomarker in MS or trials of anti-aging therapies to mitigate disability progression in MS.

PI_NAMEs: ZHANG, YINAN  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Address;Adult;Affect;Age;age acceleration;age related;age related chronic disease;aggressive therapy;Aging;aging mechanism;aging population;Animal Model;anti aging;Atrophic;Award;biological age;Biological Aging;Biological Assay;Biological Markers;Brain;career development;CDKN2A gene;Cell Aging;Cell surface;Cells;Central Nervous System;Central Nervous System Diseases;Chronic;Chronology;Clinical;clinical biomarkers;clinical practice;Cognitive;cognitive function;comparison control;Country;Cross-Sectional Studies;Data;Diffusion Magnetic Resonance Imaging;disability;Disease;Disease Outcome;Disease Progression;Disease remission;disorder risk;DNA Methylation;Early treatment;Elderly;Enrollment;epigenetic aging;epigenetic clock;experience;Failure;Fiber;Flow Cytometry;follow-up;frailty;Frequencies;Future;Genetic Processes;Geroscience;glial activation;Goals;high risk;Immune;Immune system;Immunologics;immunosenescence;Impairment;Incidence;indexing;Individual;Inflammatory;instrument;interdisciplinary approach;Interdisciplinary Study;Interest Group;Intervention;K-Series Research Career Programs;Life;Light;Link;longitudinal analysis;Magnetic Resonance Imaging;Measures;Mediating;medical specialties;Mentors;Mentorship;methylation pattern;middle age;Molecular;multidisciplinary;Multiple Sclerosis;multiple sclerosis patient;multiple sclerosis treatment;Nerve Degeneration;Nervous System Trauma;neurofilament;neuroimaging;neuroimaging marker;Neurologic Dysfunctions;Neurological disability;Neurology;Neuronal Injury;Neuropsychological Tests;old mice;Outcome;Peripheral;Persons;Phase;Phenotype;Physical Function;Physiology;predictive marker;premature;prevent;processing speed;Prognostic Marker;Progressive Disease;rate of aging;Relapse;Research;Research Personnel;Resolution;Risk Factors;Role;Scientist;Secondary Progressive Multiple Sclerosis;Secondary to;senolytics;Serology;Serum;Severities;Severity of illness;Short-Term Memory;systemic inflammatory response;T memory cell;T-Lymphocyte;T-Lymphocyte Subsets;Thalamic structure;Thinness;Time;Tissues;Translating;United States;United States National Institutes of Health;white matter;Work;young adult

PROJECT_TITLE: Associations of biological aging with outcomes and immune dysregulation in multiple sclerosis


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Pregnancy;Prevention;Primary Health Care;Rehabilitation;Serious Mental Illness;Social Determinants of Health;Telehealth;Women's Health Research

PHR: PROJECT NARRATIVE Perinatal depression affects an estimated 13% of pregnant people in the US. While effective interventions exist to prevent perinatal depression, access to facility-based in-person interventions is limited. This proposal will refine a digital group adaptation of an evidence-based prevention intervention, and evaluate its preliminary effectiveness and implementation outcomes through a pilot randomized controlled trial.

PI_NAMEs: RONEN, KESHET  (contact)

PROGRAM_OFFICER_NAME: CHU, SERENA PO-LAN

PROJECT_TERMS: Address;Administrator;Adverse effects;Affect;Age;aged;arm;Behavioral;Caring;Child;Client;Cognitive Therapy;Communication;Communities;Counseling;COVID-19 pandemic;Data;depression prevention;depressive symptoms;digital;digital intervention;effective intervention;Effectiveness;effectiveness outcome;effectiveness trial;effectiveness/implementation trial;Enrollment;Equilibrium;Ethnic Origin;Evaluation;evidence base;Evidence based intervention;experience;Facility Accesses;Focus Groups;Frequencies;Future;Goals;group intervention;Health Personnel;Health Services;Health Services Accessibility;high risk;human centered design;implementation determinants;implementation intervention;implementation outcomes;implementation protocol;implementation tool;Improve Access;Individual;Inequity;Infant;innovation;interpersonal therapy;Intervention;Interview;intimate partner violence;Language;Life Experience;Low income;low socioeconomic status;Major Depressive Disorder;Manuals;maternal morbidity;Mental Depression;Mental Health Services;mobile computing;Modeling;Modification;mood regulation;Moods;Morbidity - disease rate;Mothers;Multimedia;Names;negative mood;Participant;peer support;perceived stress;Perinatal;perinatal mental health;peripartum depression;Persons;pilot test;pilot trial;Postpartum Period;Pregnancy;pregnant;Premature Birth;Preparation;prevent;prevention service;preventive intervention;Process;programs;Provider;Public Health;Questionnaires;Race;racial minority population;racial minority women;racism;randomized trial;Randomized, Controlled Trials;Recommendation;Recording of previous events;recruit;remote intervention;Resources;Risk;Risk Factors;service providers;Services;skills;Social support;Social Workers;Spanish;Structure;success;targeted treatment;Technology;telehealth;Testing;Therapeutic Intervention;therapy design;Thinking;Time;tool;Transportation;treatment as usual;unintended pregnancy;United States Preventative Services Task Force;usability;video chat;Washington;Youth

PROJECT_TITLE: IMAGINE: pilot trial of a digital group intervention to prevent perinatal depression

STUDY_SECTION: EMHI

STUDY_SECTION_NAME: Effectiveness of Mental Health Interventions Study Section[EMHI]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Genetic Testing;Genetics;HIV/AIDS;Health Services;Human Genome;Infectious Diseases;Precision Medicine;Prevention;Sexually Transmitted Infections

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Anal cancer is a major source of morbidity in people living with HIV. Screening has been demonstrated to prevent anal cancers but current procedures are suboptimal. The objective of this study is to validate a novel genomic panel for identification of high-risk anal pre-cancers and find genomic biomarkers associated with anal cancer recurrence.

PI_NAMEs: SILVERA, RICHARD  (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Ablation;Active Learning;Address;Adoption;Age;aged;anti-cancer research;Anus;Area;Biological;Biological Markers;biomarker development;biomarker identification;biomarker panel;Biopsy;cancer genetics;cancer genomics;cancer invasiveness;cancer recurrence;Carcinoma;career;career development;Cervical;Characteristics;Chromosomes;classification algorithm;Clinical;clinical predictors;Clinical Research;Clonality;cohort;Collection;Copy Number Polymorphism;cost;Cytology;Data;Data Collection;Detection;detection test;Development Plans;Disease;DNA;DNA Sequence Alteration;DNA sequencing;driver mutation;Early Diagnosis;Electrocoagulation;Eligibility Determination;Enrollment;genomic biomarker;Genomic Instability;Genomics;Goals;high risk;high risk population;HIV;HPV-High Risk;Human;Human Papillomavirus;improved;Lesion;machine learning prediction;Malignant neoplasm of anus;Malignant Neoplasms;Mentors;Mentorship;Methods;Morbidity - disease rate;mortality;novel;novel strategies;patient oriented;Patients;Performance;Persons;Physicians;Population;Positioning Attribute;premalignant;prevent;Prevention;Procedures;Process;prospective;Prospective cohort;Provider;Recurrence;Research;research and development;Research Design;Research Personnel;Research Proposals;Resolution;Resources;Risk;risk stratification;Sampling;screening;Screening for cancer;Screening procedure;screening program;Senior Scientist;Solid;Solid Neoplasm;Source;Specificity;Squamous intraepithelial lesion;standard of care;supportive environment;Swab;Testing;Tissues;tool;Training Support;Treatment Failure;treatment group;Treatment outcome;tumor;tumor diagnosis;whole genome

PROJECT_TITLE: Optimization of anal cancer screening for people with HIV using genomic methods

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Cancer;Hematology;Immunotherapy;Orphan Drug;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE Blood cancers account for approximately 10% of all malignancies and allogeneic bone marrow transplantation (BMT) is a preferred curative therapy due to the graft-versus-leukemia (GVL) effects, in which donor T and NK cells eradicate host malignancy. Although recently, the types of APC that induce and enhance GVHD have been elucidated, the presence and nature of GVL-specific APC remain unknown. In this proposal, we will focus on identifying GVL-dependent APC in order to generate new therapeutic approaches to enhance GVL within bone marrow that do not exacerbate GVHD.

PI_NAMEs: KOYAMA, MOTOKO  (contact)

PROJECT_TERMS: Abate;Acute Graft Versus Host Disease;Alloantigen;Allogeneic Bone Marrow Transplantation;Allogenic;Antibodies;Antigen Presentation;Antigen-Presenting Cells;Antigens;Attenuated;Bone Marrow;Bone Marrow Transplantation;cancer cell;Cell Lineage;cell motility;Cell Physiology;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cessation of life;Clinical;Clinical Research;Colon;curative treatments;CXCR4 gene;Data;Disease;Endothelial Cells;engineered T cells;Excision;Exposure to;Extramedullary;Failure;Flow Cytometry;Fluorochrome;Gastrointestinal tract structure;Glucocorticoids;graft failure;graft vs host disease;graft vs leukemia effect;Hematopoietic;Hematopoietic Neoplasms;IL18 gene;Immune;Immunofluorescence Microscopy;immunological intervention;Immunologics;Immunotherapy;improved;in vivo;interleukin-18 binding protein;intravenous injection;ITGAX gene;Lead;leukemia;leukemia relapse;Light;lymph nodes;lymphoid organ;Maintenance;male;Malignant Neoplasms;Mediating;MHC Class I Genes;MHC Class II Genes;migration;Monoclonal Antibodies;Monozygotic twins;mortality;mouse model;Mus;nanobodies;Natural Killer Cells;Nature;New Agents;Normal tissue morphology;novel;novel therapeutic intervention;Opportunistic Infections;Organ;Outcome;Phase;pre-clinical;prevent;Prevention;Procedures;Process;Proto-Oncogene Protein c-kit;Recurrent disease;Relapse;relapse prevention;Resistance;response;Risk Reduction;Role;SELL gene;Site;stem cells;Stromal Cells;Syngeneic Bone Marrow Transplantation;T cell response;T-Cell Activation;T-Cell Depletion;T-Lymphocyte;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;therapy development;transcriptome sequencing;Transplant Recipients;Transplantation;villin;Viola

PROJECT_TITLE: Targeting alloantigen presentation in bone marrow to enhance graft-versus-leukemia effects

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-K (O1)]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Women's Health Research

ORG_CITY: RICHMOND

ORG_DEPT: GENETICS

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: NARRATIVE STATEMENT This project is designed to address the problem of low cancer immunogenicity by evaluating the capacity of a combination of epigenetic inhibitory agents to eliminate breast tumor cells by enhancing the antitumor immune response. Studies will include the optimization of novel inhibitors to epigenetic remodeling complexes to achieve improved effectiveness in animals.

PI_NAMEs: LANDRY, JOSEPH WILLIAM (contact);POMERANTZ, WILLIAM CHARLES KRAUSE

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: 4T1;Address;Adult;analog;Animals;anti-tumor immune response;Antigen Presentation Pathway;antitumor effect;Antitumor Response;ATAC-seq;Bioinformatics;Biological Assay;Biological Models;Biophysics;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Treatment;Bromodomain;cancer cell;Cells;Cellular Assay;chemokine;chemotherapy;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Clinical;Combined Modality Therapy;Complex;cytokine;design;Disease remission;DNA;DNA Methyltransferase Inhibitor;Down-Regulation;drug efficacy;Drug Targeting;Effectiveness;Effector Cell;Enzymes;Epigenetic Process;epigenetic therapy;Flow Cytometry;Generations;genome-wide;genome-wide analysis;Human;humanized mouse;Immune;Immune system;Immunocompetent;immunogenic;immunogenicity;Immunologic Stimulation;immunoregulation;Immunotherapy;improved;In Vitro;in vivo;in vivo Model;inhibitor;innovation;Knockout Mice;Lead;Liver Microsomes;Malignant Neoplasms;Mammals;Mediating;Metabolic;Mind;Modeling;Molecular;mouse model;Mus;Myeloid-derived suppressor cells;Natural Killer Cells;neoplastic cell;new therapeutic target;novel;novel strategies;Nucleosomes;NURF;Outcome;overexpression;Pathway interactions;Patient-derived xenograft models of breast cancer;Permeability;Pharmaceutical Preparations;pharmacologic;Property;Sampling;Series;small molecule;Sorting;Structure;Structure-Activity Relationship;success;synergism;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapy outcome;transcriptome sequencing;Transferase;Translating;translational potential;translational study;treatment strategy;triple-negative invasive breast carcinoma;tumor;Tumor Antigens;tumor growth;Tumor Immunity;Up-Regulation;Validation

PROJECT_TITLE: Enhancing Tumor Cell Immunogenicity using Improved Molecules Targeting Chromatin Remodeling

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-A (O1)]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Rare Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Glioblastoma (GBM) is the most common malignant primary brain tumor in adults, and carries a dismal prognosis that has improved little in recent decades. The goal of this study is to identify effective drug combinations tailored to the unique composition of each tumor by (1) identifying and isolating the distinct cell populations that comprise individual glioblastoma tumors, and (2) testing the drug sensitivities of each cell population. This approach has the potential to change the way this disease is studied and treated by establishing a pipeline for the identification of personalized, combinatorial drug treatments.

PI_NAMEs: PETTI, ALLEGRA ADELE (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Adult;Antibodies;antibody conjugate;Biological;biomarker identification;Cell Culture Techniques;Cell Line;Cell Separation;Cell surface;Cell Surface Proteins;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clinic;Clinical;combinatorial;Data;Development;Disease;Drug Combinations;drug resistance development;Drug Screening;drug sensitivity;drug testing;Exhibits;exome sequencing;Experimental Designs;experimental study;FDA approved;Genetic;Genetic Heterogeneity;Genetic Transcription;Genome;Glioblastoma;Goals;Heterogeneity;improved;Individual;Machine Learning;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;Molecular;multimodality;Natural Selections;neoplastic cell;new technology;novel;novel strategies;Oligonucleotides;Pathology;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacotherapy;Population;precision drugs;Primary Brain Neoplasms;Primary Neoplasm;Prognosis;Property;Proteins;Publishing;Radiology Specialty;response;RNA;Sampling;single-cell RNA sequencing;Sorting;Specificity;standard of care;Survival Rate;Techniques;temozolomide;Testing;Therapeutic;tool;tumor;tumor eradication;tumor heterogeneity;tumor-immune system interactions;Work

PROJECT_TITLE: A multimodal single-cell approach to developing personalized combinatorial treatments for glioblastoma


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Endocrine Disruptors;Maternal Health;Nutrition;Pediatric;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Microplastic contamination of the environment is ubiquitous with human exposure likely occurring though air, drinking water, food, and personal care products. Microplastics can be absorbed across cell membranes and may pose significant risks to human health. The proposed research will develop methods for measuring and characterizing microplastic exposure among the general pregnant population, which in turn will allow us to begin understanding sources of exposure and investigating human health risks associated with exposure.

PI_NAMEs: COWELL, WHITNEY  (contact)

PROGRAM_OFFICER_NAME: RAVICHANDRAN, LINGAMANAIDU V

PROJECT_TERMS: absorption;Address;Air;Behavior;Behavioral;Biological;Birth;Cell membrane;Characteristics;Chemicals;Child Health;China;Clinical;Clothing;cohort;Cohort Studies;Communities;consumer product;Cosmetics;Databases;Decidua Basalis;Delivery Rooms;density;Deposition;design;Diet;dietary;Discipline of obstetrics;drinking water;Ecosystem;Endocrine Disruptors;Environment;Environmental Exposure;Environmental Health;Europe;evidence base;exposed human population;exposure route;Exposure to;fetal;Food;food consumption;General Population;Goals;Health;Human;Individual;Infrastructure;Ingestion;Inhalation;insight;Intake;Joints;lifestyle factors;marine;Measures;Membrane;meter;Methods;milligram;modifiable lifestyle factors;Mothers;Organ;Outcome;particle;Pattern;Penetration;Perfusion;Perinatal;perinatal health;personal care products;Persons;phthalates;physical property;Placenta;Plastic Embedding;Plastics;Pollution;Polyethylene Terephthalates;Polyethylenes;Polymers;Population;Positioning Attribute;Predictive Factor;Predisposition;Pregnancy;pregnant;prenatal exposure;Production;Property;prospective;Public Health;reproductive toxicity;Research;Resistance;Risk;Risk Assessment;sample collection;Sampling;sociodemographics;Source;System;Tissues;Toxic effect;toxicant;Translating;uptake;urinary;Urine

PROJECT_TITLE: Characterizing human exposure to microplastics during pregnancy

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Hematology;Lymphatic Research;Lymphoma;Precision Medicine;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: TRANSLATION OF NONINVASIVE METABOLIC BIOMARKERS TO TARGETED THERAPY FOR CANCER PROJECT NARRATIVE  Genetic mutations in cancer alter chemical processes modifying the tumor content of substances called me- tabolites. In this program, we want to assess the possibility of measuring these metabolites using magnetic resonance spectroscopic imaging (MRSI). Using MRSI, we could measure treatment-related changes in tumor metabolites in cancer patients without obtaining tumor pieces, using injections or radiation.

PI_NAMEs: ARIAS-MENDOZA, FERNANDO ;NATH, KAVINDRA  (contact)

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: Affect;Agammaglobulinaemia tyrosine kinase;Age;Alanine;Anatomy;Aspartate;Attention;B lymphoid malignancy;B-Cell Activation;B-Cell Antigen Receptor;B-Lymphocytes;Biological Markers;Body part;Cancer Patient;cancer therapy;Carbon;Cardiac;Cell division;cell growth;Cell Line;Cells;Chemicals;Clinical;clinical translation;cohort;DNA Sequence Alteration;Ensure;Evaluation;Feasibility Studies;Fermentation;Funding;Future;Glucose;glucose uptake;Glutamates;Goals;Growth Factor Receptors;healthy volunteer;Human;human subject;Hyperactivity;imager;imaging modality;improved;In Situ;Indolent;Injections;interest;Lipids;Location;loss of function;Lymphocyte;macromolecule;magnetic field;Magnetic Resonance;magnetic resonance spectroscopic imaging;Malignant lymphoid neoplasm;Malignant Neoplasms;Mantle Cell Lymphoma;Measures;Metabolic;Metabolism;Methods;Mitochondria;Modeling;Movement;Mus;Oncogenes;Oxidative Phosphorylation;Oxygen;Pathogenesis;Pathway interactions;Patients;preclinical study;predictive marker;Procedures;Process;programs;Proliferating;Protein Biosynthesis;Publishing;quantum;Radiation;Receptor Signaling;Relapse;Respiration;response;response biomarker;Sample Size;Serine;sex;Signal Pathway;Signal Transduction;targeted cancer therapy;targeted treatment;Testing;Tissues;Translations;treatment choice;treatment response;tumor;Tumor Burden;tumor growth;Tumor Suppressor Genes;Tumor Volume;tumor xenograft;United States Food and Drug Administration;Vertebral column;Warburg Effect;Water;Work;Xenograft procedure

PROJECT_TITLE: Translation of Noninvasive Metabolic Biomarkers to Targeted Therapy for Cancer