ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: NUTRITION

PHR: PROJECT NARRATIVE Standard behavioral weight loss interventions have been less effective for Black adults, who have the highest prevalence of obesity and would benefit from interventions that address important cultural factors. Family- centered behavioral weight loss interventions address the cultural significance of the familial social network in weight loss among Black adults and the need to move beyond individual approaches for health behavior changes in chronic disease management. We propose a study using the Multiphase Optimization Strategy (MOST) to determine the optimal combination of family components and component levels, and Social Network Analysis (SNA) to identify how interactions within social networks (family and non-family) influence individual behaviors among Black adults in a family-centered behavioral weight loss intervention.

PI_NAMEs: SAMUEL-HODGE, CARMEN D (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Address;Adult;Area;Behavior;behavior change;Behavior monitoring;Behavioral;Black race;Body mass index;Body Weight;Body Weight Changes;Body Weight decreased;cardiovascular health;Chronic Disease;clinically significant;cohesion;Communication;Communities;Conflict (Psychology);contextual factors;coping;Coupled;Couples;data warehouse;Diabetes Mellitus;diabetes self-management;dietary;Disease Management;Distal;Eating;Effectiveness;Engineering;Ethnic Population;Evaluation;evidence base;experience;Experimental Designs;experimental study;Family;Family member;family support;follow-up;Gender;Glycosylated hemoglobin A;Goals;Health;Health behavior change;health disparity;High Prevalence;improved;indexing;Individual;innovation;Interpersonal Relations;Intervention;intervention delivery;Joints;Life Style;Malignant Neoplasms;Marketing;Mediation;Mediator;member;Methodology;Methods;Modeling;multi-component intervention;multiphase optimization strategy;Obesity;obesity treatment;Outcome;Participant;Pathway Analysis;Persons;Physical activity;Population Group;Prevalence;programs;racial population;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;recruit;relative effectiveness;Research;Resources;Sampling;Services;skills;skills training;Social Network;Social support;Spouses;statistics;stressor;Structure;Subgroup;Testing;Training;United States;Weight;weight loss intervention;weight loss program

PROJECT_TITLE: FAMily-centered WEight Loss for Black Adults (FAM WEL B-ing): Optimization and Evaluation using Multiphase Optimization Strategy (MOST) and Social Network Analysis (SNA)

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT (JA)]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: COLLEGE PARK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHOLOGY

ORG_FIPS: US

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: PROJECT NARRATIVE Investigating developmental risk and protective factors that are associated with anxiety symptoms within a racially diverse autistic population is critical to prevent or reduce negative mental health outcomes. The current study aims to collect a large sample of racially diverse autistic and nonautistic adolescents to evaluate whether the presence of atypical autonomic activity is a biomarker of anxiety in autistic youth. Such knowledge will allow for identification of anxiety in autistic youth that would otherwise be unable to report on anxiety and inform the development of interventions that are generalizable to a racially diverse population.

PI_NAMEs: YARGER, HEATHER  (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: 14 year old;Adolescent;adolescent with autism spectrum disorder;African American;aged;Aggressive behavior;Anxiety;Anxiety Disorders;anxiety symptoms;autism spectrum disorder;autistic;autistic children;Biological;Biological Markers;Black race;career development;Child;Clinical Sciences;Communities;contextual factors;Data;demographics;depressive symptoms;Development;Development Plans;Diagnosis;diagnostic biomarker;Ecological momentary assessment;Electrocardiogram;empowerment;Ensure;Environment;Ethnic Origin;Exclusion;Exhibits;experience;Family member;Goals;health equity;heart rate monitor;heart rate variability;improved;Individual;individuals with autism spectrum disorder;Intervention;Investigation;Knowledge;male;Maryland;Measurement;Measures;Mental Health;Methodology;Methods;Minority;Moods;multilevel analysis;multimodality;Outcome;Outcome Measure;Parasympathetic Nervous System;Participant;Patient Self-Report;peer;Physiological;Population;Population Heterogeneity;Positioning Attribute;prevent;primary outcome;protective factors;Psychopathology;Psychophysiology;Quality of life;Race;racial diversity;recruit;Reporting;Research;Research Personnel;Respiration;respiratory;response;Rest;Risk Factors;Role;Sample Size;Sampling;Self-Injurious Behavior;Sinus Arrhythmia;skills;standard measure;Stimulus;Stress;supportive environment;Sympathetic Nervous System;System;teacher;therapy development;Time;Training;trait;Well in self;Youth

PROJECT_TITLE: Assessing Anxiety in Adolescents with Autism Spectrum Disorder: The Role of Autonomic Activity as a Biomarker

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BALTIMORE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative  Among the increasing number of dementia patients worldwide, most patients have additional contributors other than plaques and tangles, such as vascular disorders. This project will develop a non-invasive magnetic resonance imaging method to measure arterial cerebral blood volume and determine its relationship with cognitive function in the early stage of dementia. Identifying vascular contribution to cognitive impairment and dementia advances understanding of the disease pathology, diagnosis, and intervention at an early stage.

PI_NAMEs: XU, FENG  (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Applications Grants;arterial spin labeling;Atrophic;Autopsy;bioimaging;Biological Markers;Biomedical Engineering;Blood Vessels;Blood Volume;career;cerebral blood volume;cerebrovascular reactivity;Clinical;Clinical Research;clinical training;Cognition;Cognitive;cognitive function;cognitive performance;cohort;Core-Binding Factor;cost effective;Dementia;Development;Diagnosis;Disease;Engineering;experience;Foundations;Fourier Transform;Funding;Goals;grasp;Hypercapnia;Image;imaging biomarker;imaging modality;imaging scientist;Imaging Techniques;Impaired cognition;Individual;innovation;insight;Intervention;Knowledge;Life;Liquid substance;Longitudinal Studies;Magnetic Resonance Imaging;Measurement;Measures;Mentors;Mentorship;Metabolic;Methods;Microvascular Dysfunction;mild cognitive impairment;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroimaging;normal aging;novel;Older Population;Outcome;Participant;Pathology;Patients;Persons;Play;Principal Investigator;quantitative imaging;Radiology Specialty;Reporting;Research;Research Design;Research Personnel;response;Role;skills;Structure;symposium;Techniques;Testing;Time;Tissues;tool;Training;Training Activity;Translating;United States;United States National Institutes of Health;vascular cognitive impairment and dementia;Vascular Dementia;Vascular Diseases;vascular factor;Vasodilation;Work

PROJECT_TITLE: Imaging Vascular Function in Normal Aging, MCI, and Mild Dementia

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Hematology;Immunization;Immunotherapy;Infectious Diseases;Pediatric;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation;Vaccine Related

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: PROJECT NARRATIVE The proposed research will study whether infusions of T cells targeting the SARS-CoV-2 virus are safe and effective in restoring immunity in patients who have undergone bone marrow transplant. It will additionally study ways to produce T cells targeting SARS-CoV-2 that will function even in the presence of immunosuppressive drugs that interfere with T cell function. This application outlines an experimental plan, mentorship team, and targeted didactics that will provide the candidate with the experience and support needed for her to attain graduated research independence by the end of the award period.

PI_NAMEs: CONWAY, SUSAN  (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: 2019-nCoV;adaptive immunity;Adoptive Cell Transfers;Adoptive Immunotherapy;Adoptive Transfer;Adult;Advisory Committees;alemtuzumab;Allogenic;antiviral immunity;Award;Bioinformatics;Biological Assay;Blood;Blood specimen;Bone Marrow Transplantation;Cancer Center;career;CD8B1 gene;CDW52 gene;Cell Physiology;Cell Therapy;Cells;Child;Childhood;Clinical;Clinical Sciences;Clinical Trials Design;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;COVID-19 vaccine;CRISPR/Cas technology;Critical Care;Critically ill children;cytokine;cytokine release syndrome;Cytomegalovirus;Cytometry;cytotoxicity;deep sequencing;Development;Dose;early phase clinical trial;effective therapy;efficacy evaluation;Engineered Gene;engineered T cells;Enrollment;Environment;experience;experimental study;Flow Cytometry;Foundations;Frequencies;Future;gene therapy;Genes;Genetic Engineering;Genetic Medicine;genetically modified cells;Goals;Good Manufacturing Process;graft vs host disease;Half-Life;Hematopoietic Stem Cell Transplantation;High-Throughput Nucleotide Sequencing;Hospitals;Human Herpesvirus 4;Immune;immune reconstitution;Immunity;Immunobiology;Immunology;immunomodulatory therapies;Immunosuppressive Agents;Immunotherapy;in silico;In Vitro;in vitro activity;in vivo;Infection;Infusion procedures;Institution;Institutional Review Boards;Interferon Type II;International;K-Series Research Career Programs;Knock-out;Laboratories;Life;Medical;Memory;Mentors;Mentorship;Monitor;Monoclonal Antibodies;Morbidity - disease rate;neutralizing antibody;next generation;novel;Oncogenes;Oncology;patient population;Patients;pediatric patients;Persons;Pharmaceutical Preparations;Phase I Clinical Trials;Phenotype;Population;Positioning Attribute;post-transplant;predictive tools;prevent;Prevention;Prevention strategy;Production;prophylactic;Prophylactic treatment;Proteins;Protocols documentation;Qualifying;reconstitution;Regimen;Research;Research Personnel;Research Proposals;Resistance;Resources;respiratory virus;Risk;Safety;SARS-CoV-2 immunity;SARS-CoV-2 infection;Scientist;Serotherapies;single-cell RNA sequencing;Site;T cell receptor repertoire sequencing;T cell therapy;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapy trial;Toxic effect;Training;Translational Research;Transplant Recipients;Transplantation;transplantation therapy;United States National Institutes of Health;Vaccinated;Vaccination;Vaccines;Variant;Viral;Viral Physiology;Virus;Virus Diseases;Virus Shedding;Work

PROJECT_TITLE: K23 Resubmission - Impact of adoptive T cell therapy on immunity to SARS-CoV-2 after bone marrow transplant

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (JA)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Underage Drinking;Women's Health Research

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

ORG_STATE: MA

PHR: Project Narrative [Sexual minority women experience disproportionate health inequities including risky drinking behaviors, partly due to structural stigma, and these impacts may extend to their offspring; however, the mechanisms that mediate and moderate these associations, as well as how they unfold throughout the lifecourse, remain un- known. The proposed research will examine how exposure to structural stigma throughout life impacts alcohol consumption of sexual minority women and their offspring in two unique, linked, longitudinal, intergenera- tional cohorts. These findings will lay the groundwork to reveal which individual resiliency factors and inter- personal determinants protect against the effects of structural stigma, advancing understanding of mechanisms of risk and modifiable protective factors—ultimately informing future modifiable targets for protecting against the impact of stigma on risky drinking.]

PI_NAMEs: MCKETTA, SARAH CLAIBOURNE (contact)

PROGRAM_OFFICER_NAME: BALACHOVA, TATIANA NIKOLAYEVNA

PROJECT_TERMS: Address;Adolescence;Adult;Adverse effects;Age;Alcohol consumption;alcohol misuse;alcohol risk;Alcohols;Attitude;Award;career development;Characteristics;Child;Child Health;Child Rearing;cohort;Cohort Studies;Congresses;Data;data structure;Disparity;drinking behavior;Enrollment;examination questions;experience;Exposure to;Female;Foundations;Future;Generations;Geography;Health behavior;health disparity;health inequalities;Heterosexuals;high risk;high risk drinking;high risk population;Hostility;Individual;Infant;Infant Health;innovation;Institutional Policy;intergenerational;Knowledge;Lesbian;Lesbian Gay Bisexual Transgender;Libraries;Life;Life course epidemiology;Life Cycle Stages;Link;marginalized population;Measurement;Measures;Mediating;Mental Health;Mentors;Mentorship;Minority Groups;modifiable risk;Mothers;National Institute on Alcohol Abuse and Alcoholism;Natural Language Processing;news;Newspapers;novel;Nurses;Nurses' Health Study;offspring;Parents;Participant;Pattern;Personal Satisfaction;Phase;Policies;protective factors;Questionnaires;Reporting;Research;Research Personnel;Research Proposals;resilience factor;Resources;Respondent;Risk;Risk Factors;Risk Reduction;self esteem;Sex Orientation;sexual minority;sexual minority health;sexual minority women;sexual minority youth;Social Environment;social group;social stigma;Stigmatization;Techniques;Testing;Text;Time;time use;tool;Training;US State;Woman;Work

PROJECT_TITLE: Associations between structural stigma and alcohol use among sexual minority women and their offspring

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Neurosciences;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: BOSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: This project is relevant to public health because it directly addresses two opportunity gaps in biomedical science education that are particularly relevant to students from Historically Underrepresented Groups (HUGs - BIPOC, women, first generation college students and people from economically disadvantaged backgrounds) namely their need for the information and skills that allow them to make informed decisions about their health and that fosters their participation in the STEM+M workforce. This innovative three-phase program 1) integrates in-school instruction in the science underlying addiction with instruction in the high level competencies required for health literacy and participation in 21st century STEM+M careers; 2) provides teachers with comprehensive professional development to optimize implementation in the classroom and 3) performs a rigorous research study to evaluate the impacts of the curriculum on student self-efficacy toward seeking out health information and career awareness. Teaching the science behind addiction while helping students develop their scientific reasoning skills in the context of career awareness will therefore foster both health literacy and informed career choices.

PI_NAMEs: MEIRI, KARINA F (contact)

PROGRAM_OFFICER_NAME: BECK, LAWRENCE A

PROJECT_TERMS: addiction;Addictive Behavior;Address;Adopted;Adult;Affect;Age;age group;Applied Skills;Attention;Biology;Black, Indigenous, People of Color;Boston;Brain;broadening participation research;career;career awareness;Career Choice;case-based;Cognitive;Communities;Competence;cost;Data;Data Analyses;design;Development;digital;disadvantaged background;Disease;doctoral student;E-learning;Eating;economic impact;Economically Deprived Population;Educational Curriculum;Educational process of instructing;Educational workshop;Equilibrium;European;Evaluation;Exclusion;experience;Exposure to;First Generation College Students;Fostering;Goals;Health;Health behavior change;health literacy;health management;Health Promotion;Health Sciences;Healthcare Systems;high school;High School Student;Individual;innovation;Instruction;instrument;interest;Intervention;Knowledge;Learning;Life;literate;Measures;Medical;Medical Students;Mentors;Minority;model development;Modeling;multidisciplinary;National Institute of Drug Abuse;Neurobiology;Neurosciences;novel;Palpable;Pathway interactions;pedagogy;Persons;Phase;Postdoctoral Fellow;Predisposition;preventive intervention;Problem Solving;Program Sustainability;programs;Public Health;Readiness;Recovery;Research;research study;response;Rewards;Risk;Risk Assessment;Role playing therapy;Schools;Science;science education;science teacher;science, technology, engineering, mathematics, and medicine;Scientist;Self Efficacy;skills;social;Social Impacts;social stigma;Specialist;Strategic Planning;student mentoring;Students;substance use;Substance Use Disorder;substance use prevention;Surveys;teacher;Teacher Professional Development;Teenagers;theories;Time;tv watching;Underrepresented Populations;Vulnerable Populations;Woman

PROJECT_TITLE: Addictive Behaviors: A collaborative co-design program to promote health literacy and career awareness in high schools

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-L (55)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Neurosciences;Nutrition;Prevention;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE Psychostimulant use disorder accounts for a third of overdose deaths, however, currently there is no FDA- approved pharmacotherapy to treat it. Recent evidence suggests a role for diet and gut signaling in modulating the dopaminergic reward signaling and SUD behavior. I propose to use a recently developed amphetamine preference assay in Drosophila to identify the environmental factors, like dietary components, as well as signaling pathways that modulate this SUD-related behavior.

PI_NAMEs: TITOS VIVANCOS, IRIS  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: addiction;Affect;Alcohol consumption;alcohol response;Amino Acids;Amphetamines;Behavior;Behavior Disorders;Behavior Therapy;Behavioral Assay;behavioral response;Biological;Biological Assay;Brain;career;Cell secretion;Cessation of life;Cocaine;Consumption;Development;Diet;Dietary Component;Disease;disorder prevention;dopaminergic neuron;Drosophila genus;Drug abuse;Drug Regulations;Endocrine system;Environmental Risk Factor;experience;experimental study;Exposure to;FDA approved;feeding;fly;Food;Food Supplements;gene conservation;Generations;Genes;Genetic;Goals;gut endocrine cell;gut-brain axis;Hand;high throughput screening;Human;Individual;insight;Intervention;Investigation;knock-down;Knowledge;Lifestyle-related condition;Link;Mammals;Mediating;Mental Health;Methamphetamine;model organism;Modeling;Molecular;Monitor;Neurobiology;Neurons;Neuropeptide Receptor;Neuropeptides;neurotransmission;novel;novel strategies;Nutrient;Orthologous Gene;overdose death;Peptides;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Population;preference;Prevention;Preventive;programs;Proteins;psychostimulant;Public Health;Reaction;Reagent;receptor;Recovery;Reporter;Research;Research Personnel;response;Rewards;Risk Factors;Role;Signal Pathway;Signal Transduction;Sleep;stimulant use disorder;Substance Use Disorder;substance use treatment;System;Time;tool;Training

PROJECT_TITLE: Mechanisms of diet modulating experience-dependent amphetamine preference

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ADMINISTERING_IC: CA

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: College Station

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

ORG_STATE: TX

PHR: PROJECT NARRATIVE Dietary supplements are an important contributor to overall micronutrient (i.e. vitamins and minerals) exposures for a large proportion of the population. We developed and validated a metric, the total nutrient index (TNI), that captures multiple micronutrient exposures inclusive of supplements for use in research, clinical, and monitoring settings. This current project will update the TNI to identify critical micronutrients and in what combinations optimally benefit the health and nutrition of individuals across the life course, and relate the TNI to risk factors, health outcomes, and mortality.

PI_NAMEs: BAILEY, REGAN  (contact);TOOZE, JANET A.

PROGRAM_OFFICER_NAME: REEDY, JILL

PROJECT_TERMS: Address;Adherence;Adult;Agreement;American;Award;bioactive food component;Biological Availability;Biological Markers;Blood Pressure;Body Composition;bone;Child;Chronic Disease;Clinical;cohort;Consumption;Data;design;Development;Diet;dietary;Dietary Component;dietary guidelines;Dietary intake;dietary supplements;Disease;disorder prevention;disorder risk;Eating;Exposure to;Food;Food Supplements;Future;Health;Health Benefit;Health Promotion;Health Status;Healthy Eating;Human;improved;indexing;Individual;Infant;Inflammation;innovation;Intake;Lactation;Life;Life Cycle Stages;Literature;Machine Learning;Markov Chains;Measures;Methods;Micronutrients;Minerals;Modeling;Monitor;Morbidity - disease rate;mortality;mortality risk;National Health and Nutrition Examination Survey;novel;Nutrient;nutrition;Nutritional;nutritional approach;Nutritional status;older adult;Outcome;Pattern;Population;precision nutrition;pregnant;Public Health;public health relevance;Research;Research Personnel;Risk;Risk Factors;risk prediction;Sampling;Scientific Advances and Accomplishments;Scientist;Source;Subgroup;Surrogate Markers;System;Techniques;United States National Institutes of Health;Update;Vitamins;Woman

PROJECT_TITLE: Development of a Total Nutrient Index

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Lung;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: GAINESVILLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Cervical spinal cord injury induced respiratory complications are a leading cause of mortality and morbidity in this patient population, underscoring a critically unmet need. The fundamental goal of this proposal is to employ a combinatorial approach (transcutaneous spinal direct current stimulation in conjunction with ampakine pharmacotherapy) to enhance respiratory function after a cervical spinal cord injury. These studies will directly test whether this combinatorial therapy can be used as a safe and neuroplasticity-inducing rehabilitation modality for eventual translation into humans with incomplete chronic spinal injury, all the while, setting a foundation for the applicant (Dr. Rana) to launch an independent research career.

PI_NAMEs: RANA, SABHYA  (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Acids;Acute;Address;AMPA Receptors;Anesthesia procedures;Animals;awake;Behavior;Blood gas;Brain Stem;Breathing;career;Career Choice;Cervical;Cervical spinal cord injury;Cervical spinal cord structure;Chronic;combinatorial;Communities;Coughing;Cutaneous;Data;design;Development;Disease;Dose;efficacy testing;Electrodes;Environment;experience;experimental study;Florida;Foundations;Glutamates;Goals;Home;Human;improved;in vivo;Injury;instrument;interdisciplinary approach;Laboratories;Legal patent;Letters;Mentors;Methods;Modality;Modeling;Monitor;Morbidity - disease rate;mortality;Motor;motor control;motor disorder;Motor Neurons;Motor output;motor recovery;Muscle;neural;Neurobiology;neurological rehabilitation;neuronal excitability;Neuronal Plasticity;Neurons;neurophysiology;neuroregulation;neurotransmitter release;novel;Output;Pathway interactions;patient population;Pharmacotherapy;Phase;Phrenic Motor System;Physiological;Population;positive allosteric modulator;Preparation;preservation;programs;Protocols documentation;Rana;Rattus;receptor;rehabilitation paradigm;Rehabilitation therapy;Research;respiratory;respiratory challenge;Respiratory Diaphragm;Respiratory Insufficiency;Respiratory physiology;Rodent;Scientist;Secure;skills;Skin;Spinal;Spinal cord injury;Spinal Injuries;spinal pathway;Stimulus;Structure;Structure of phrenic nerve;Surface;sustained recovery;System;Technical Expertise;Testing;Therapeutic;Tissues;Translations;Universities;ventilation;Work

PROJECT_TITLE: Spinal Direct Current Stimulation to Enhance Breathing Following Cervical Spinal Cord Injury

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Cardiovascular;Genetics;Human Genome;Lymphatic Research;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: PROJECT NARRATIVE The vascular and lymphatic systems are essential for delivering oxygen and nutrients to organs, removing waste products and regulating tissue fluid homeostasis and immune cell trafficking. We propose to define the role of nuclear hormone receptor NR2F1/2 in the specification of arterial, venous and lymphatic endothelium, reveal the molecular mechanisms that regulate ligand-dependent NR2F1/2 transcription and provide a structural basis for designing synthetic agonists/ antagonists to modulate NR2F1/2 activity. The proposed research is relevant to public health because a thorough understanding of transcriptional networks driving endothelial development is critical for designing regenerative treatments to repair blood and lymphatic vessels damaged by congenital conditions or disease. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to developing of fundamental knowledge that will help reduce the burdens of illness and disability.

PI_NAMEs: IVANOVA, NATALIA B (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Acceleration;Affect;Agonist;Amino Acids;Anabolism;analog;angiogenesis;Angiogenesis Inhibition;antagonist;apoAI regulatory protein-1;Atherosclerosis;Automobile Driving;base;Binding;Biochemical;Biological Assay;Blood;Blood Vessels;burden of illness;cancer immunotherapy;Cardinal vein;cdc Genes;Cell Cycle Regulation;Cell Differentiation process;cell type;Cells;Chemicals;chicken ovalbumin upstream promoter-transcription factor;Clinical;cofactor;Complex;CRISPR screen;Cryoelectron Microscopy;Data;Defect;design;Development;Diet;differentiation in vitro;Dimerization;disability;Disease;Embryo;Endothelial Cells;endothelial stem cell;Endothelium;Family;Fluid Balance;gain of function;Genes;Genetic;Genetic Transcription;genome-wide;Genomics;Germ Lines;Homologous Gene;Human;human embryonic stem cell;Iliac Vein;Image;Immune;In Vitro;in vitro Model;in vivo;innovation;Knowledge;Ligand Binding;Ligands;loss of function;Lymphangiogenesis;Lymphatic;lymphatic development;Lymphatic Endothelial Cells;Lymphatic Endothelium;Lymphatic System;lymphatic vasculature;lymphatic vessel;MAP Kinase Gene;Maps;Mediating;member;Metabolic Control;Metabolism;Methodology;Mission;Modeling;Molecular;Mus;mutant;Mutate;Mutation;Myocardial Infarction;neovascular;notch protein;Nuclear Hormone Receptors;Nuclear Receptors;Nutrient;Organ;organoid transplantation;Orphan;Oxygen;Pathway interactions;Physiological;Physiology;prevent;progenitor;protein structure;Public Health;receptor;regenerative treatment;repaired;Research;Resolution;Role;secondary lymphedema;Signal Transduction;single-cell RNA sequencing;small molecule;Source;Specific qualifier value;Sphingolipids;stem cells;Structure;success;Supplementation;Technology;Testing;therapeutic target;three-dimensional modeling;tissue regeneration;Tissues;trafficking;transcription factor;transplant model;tumor growth;United States National Institutes of Health;uptake;Validation;Vascular Diseases;Vascular Endothelial Cell;Vascular System;Veins;Venous;Waste Products;Work;wound healing

PROJECT_TITLE: Metabolic control of human endothelial development via the COUP-TF/1-deoxysphingosine axis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-C (02)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Autism;Brain Disorders;Climate-Related Exposures and Conditions;Clinical Research;Contraception/Reproduction;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Social Determinants of Health

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: The study will examine the role of paternal factors in risk of autism spectrum disorder (ASD). I will examine whether exposure to air pollution during the sperm development period preceding a conception is associated with risk of autism in the offspring, and the additive or synergistic effects of paternal comorbidities and related pharmacologic treatments during spermatogenesis. I will also examine whether exposure to air pollution is associated with changes in the sperm methylome overall and specifically in ASD related loci, which might inform mechanistic pathways.

PI_NAMEs: ROTEM, RAN  (contact)

PROGRAM_OFFICER_NAME: LAWLER, CINDY P

PROJECT_TERMS: Address;Affect;Age;Air Pollution;ambient air pollution;Animal Model;Animals;Attenuated;autism spectrum disorder;Behavioral;Biological;Birth;Characteristics;Child;Clinic;Clinical;cohort;comorbidity;Conceptions;Data;Data Set;Development;Diabetes Mellitus;Disease;disorder risk;DNA Methylation;Dyslipidemias;Environmental Exposure;Environmental Health;Environmental Pollutants;Environmental Risk Factor;Epidemiology;Epigenetic Process;Etiology;Exposure to;Financial cost;Functional disorder;Future;Gene Expression;Genetic;genome wide methylation;genomic locus;Genomics;Goals;Human;human data;imprint;improved;Inflammation;Inherited;innovation;Intervention;Joints;Lead;Link;Location;Maternal Exposure;Mediating;men;Mentors;methylome;Modeling;Neurodevelopmental Disorder;Neuroepidemiology;Neurologic;neurotoxic;novel;Obesity;offspring;Outcome;Oxidative Stress;Parents;Paternal Age;Paternal Exposure;Pathway interactions;perinatal period;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Phenotype;Play;postnatal period;Pregnancy;prenatal;Prevalence;psychosocial;Reporting;Research;Research Design;Research Personnel;Risk;Risk Factors;Role;Seminal fluid;Severities;skills;societal costs;sperm cell;sperm quality;Spermatogenesis;stem;Subgroup;Symptoms;Thyroid Diseases;Tissues;Toxic Environmental Substances;Training;trait;transmission process;Twin Studies;Work

PROJECT_TITLE: Paternal exposures, sperm epigenetic marks, and autism spectrum disorder in offspring

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LWJ-W (K9)]


ADMINISTERING_IC: HS

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: DURHAM

ORG_NAME: NORTH CAROLINA CENTRAL UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE The goal of this project is to improve clinical practice for autistic children by eliciting Black caregivers’: a) suggestions for clinical decision support customization; b) perceptions of a novel digital autism screener and c) thoughts on facilitators and barriers to study engagement. Early intervention can mitigate long-term disability associated with autism, but Black children continue to experience disparities in access to early services due, in part, to inaccurate screening, lack of evaluation referrals resulting in limited linkage to services after positive screening results, and underrepresentation in research samples. The proposed research is relevant to AHRQ goals because it can advance knowledge concerning improvement of the quality, equity, and accessibility of health care for autistic children.

PI_NAMEs: FANNIN, DANAI CONNIE FRANCIS (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Acceptability, Feasibility, and Appropriateness of Digital Autism Screening, Clinical Decision Support, and Research Engagement for Black Children

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Social Determinants of Health;Suicide;Suicide Prevention;Telehealth;Violence Research;Youth Violence

PHR: Project Narrative  Text-message-based services have the potential to greatly improve access to crisis support for persons who are at risk of suicide, especially for adolescents and young adults, who may be more comfortable using text- based platforms than voice-based telephone services. Utah has made a statewide text-message-based crisis service (SafeUT) available to teens and young adults since 2017. We propose to use advanced statistical analysis methods to assess, in a geographically-sensitive manner, the causal impact of SafeUT on key markers of adolescent crisis outcomes throughout the state, including emergency room visits, hospitalizations for psychiatric reasons, and suicide deaths, using comparison data from Colorado.

PI_NAMEs: KIOUS, BRENT MICHAEL (contact);MEDINA, RICHARD

PROGRAM_OFFICER_NAME: LUSHIN, VICTOR

PROJECT_TERMS: Access to Information;Accident and Emergency department;Admission activity;Adolescent;Adolescent and Young Adult;Age;Altitude;Appointment;Behavior;Cause of Death;Cellular Phone;Censuses;Collection;Colorado;Communities;Counseling;Country;Data;data resource;Data Sources;Databases;Death Records;Demographic Factors;Development;economic determinant;Emergency department visit;Evaluation;evidence base;experience;Firearms;Geography;Goals;Health;Health care facility;health determinants;health service use;Healthcare;Hospitalization;Improve Access;improved;Incidence;Individual;inpatient psychiatric treatment;Interruption;Intervention;Label;Location;Measurable;Measures;Medical;Medical Examiners;Mental Health;Mental Health Services;mental representation;Methods;Modeling;Outcome;Outpatients;Ownership;Pattern;Persons;Population Database;Population Density;Poverty;Primary Care;programs;Reporting;Resources;response;Rest;rurality;Safety;school district;Schools;Series;service delivery;Services;social disparities;sociodemographics;Socioeconomic Status;spatiotemporal;Statistical Data Interpretation;Statistical Methods;Students;substance use;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide prevention;suicide rate;System;Teenagers;telephone based;Text;Text Messaging;Time;Universities;uptake;Utah;Visit;Voice;young adult;Youth

PROJECT_TITLE: Impact of a mobile phone crisis text messaging application on the spatiotemporal distribution of mental health outcomes among Utah adolescents.

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Contraception/Reproduction;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Immune cells in a mother’s uterus help the embryo receive the blood and nutrients it needs to grow. When a fetus fails to grow in the womb, both mother and fetus are in danger of death or major disability. This project will provide important information about how specialized immune cells called macrophages help the uterus to nurture the fetus throughout pregnancy, keeping mother and fetus safe from harm.

PI_NAMEs: GORDON, SCOTT MICHAEL (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Acceleration;adaptive immune response;adverse pregnancy outcome;Advisory Committees;Affect;American;ATAC-seq;Award;Biochemical;Biochemistry;Bioinformatics;Biological;Blood;career development;Cells;Cellular Immunology;cellular targeting;Cessation of life;Child Support;Chromatin;Clinical;conditional knockout;congenital infection;cost;cytokine;Cytokine Signaling;Data;Development;disability;Disease;Distal;Doctor of Philosophy;Embryo;Ensure;Environment;Enzyme-Linked Immunosorbent Assay;epigenomics;Exposure to;Faculty;Fellowship;fetal;Fetal Development;Fetal Growth Retardation;Fetal health;Fetus;Flow Cytometry;Foundations;Functional disorder;functional outcomes;Funding;Genes;Genetic Transcription;Goals;Growth;health of the mother;healthy pregnancy;Homeostasis;Human;IL2RB gene;Immune;Immunity;Immunologics;Immunologist;in vivo;in vivo Model;Inflammation;Inflammatory;inflammatory modulation;innovation;instructor;interest;Interferons;Interleukin-10;Interleukin-15;interleukin-15 receptor;International;Investigation;K-Series Research Career Programs;Kinetics;Knockout Mice;Knowledge;Life;Literature;Lymphocyte;Macrophage;Maternal Health;maternal outcome;Maternal-Fetal Exchange;Mediating;Mentors;Mentorship;Methods;Molecular;Mothers;mouse model;Mus;Myeloid Cells;Natural Immunity;Natural Killer Cells;Neonatal;Neonatology;next generation sequencing;novel;Nutrient;Outcome;Oxygen;Pathway interactions;Pediatric Hospitals;Pediatrics;Pennsylvania;perinatal medicine;Personal Satisfaction;Philadelphia;Phosphorylation;Physicians;Placenta;Placental Biology;Placentation;Play;Population;Pre-Eclampsia;Pregnancy;Pregnancy Complications;Pregnancy Outcome;Productivity;Property;Public Health;reproductive;Reproductive Biology;Reproductive Immunology;Research;Research Personnel;Residencies;Resources;response;Role;Scientist;Shapes;Signal Transduction;STAT3 gene;Stat5 protein;Techniques;Testing;Training;transcriptome sequencing;transcriptomics;Universities;Uterus;Vascular remodeling;Viral;Virus Diseases;Western Blotting;Work

PROJECT_TITLE: Functions for novel IL-15-responsive macrophages in the uterus during pregnancy

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Emergency Care;Networking and Information Technology R&D (NITRD)

ORG_CITY: SAN ANTONIO

ORG_NAME: MEDCOGNITION, INC.

PHR: The proposed research is relevant to public health because it enables more effective training for HAZMAT professionals, which will result in saving lives. This project is relevant to NIEHS’s mission because it applies mixed reality treatments in a novel approach to enhance the realism of HAZMAT simulation and training, thereby better preparing trainees for real scenarios.

PI_NAMEs: UNRATH, RUSSELL  (contact)

PROGRAM_OFFICER_NAME: PERSAUD, ERIC

PROJECT_TERMS: Address;Algorithms;Ambulances;animation;artist;automated assessment;Back;commercialization;Competence;Computer software;Corrosives;cost;Coughing;Crackles;Crying;Data;Defibrillators;Development;Diarrhea;E-learning;Education;Electricity;Emergency medical service;Emergency Medicine;Emotional;Environment;Epinephrine;Erythema;Evaluation;Eye;Fees;first responder;Funding;Gases;Goals;Grant;haptics;Hazardous Substances;heart rhythm;Hospitals;Human Resources;improved;Individual;Inhalation;Injury;innovation;Institution;instructor;Internet;Interview;irritation;Lacrimation;Learning;learning outcome;lectures;Legal patent;Literature;Manikins;Mechanics;Medical;Miosis disorder;Mission;mixed reality;Modeling;Muscle;National Institute of Environmental Health Sciences;Nausea;novel;novel strategies;operation;Outcome;Pain;Participant;Patient Recruitments;Patient Simulation;Patients;Performance;Persons;Pharmaceutical Preparations;Pharyngeal structure;Physiologic Monitoring;Population;portability;Procedures;Process;prototype;Public Health;Questionnaires;Research;research and development;Resolution;Respiratory Sounds;response;Series;Signs and Symptoms;simulation;simulation game;skills;Skin;skin irritation;Small Business Innovation Research Grant;sound;Steel;Students;success;Surface;Symptoms;System;Tablets;Technology;Text;Texture;Time;Training;Underserved Population;Urination;usability;user centered design;Vesicle;virtual;Visual;Vomiting;Work

PROJECT_TITLE: Interactive Treatments for HAZMAT Training with the PerSim Mixed Reality Patient Simulator

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 ARL-K (R4)]


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: Atlanta

ORG_NAME: COUNCIL OF STATE & TERRITORIAL EPIDEM

PHR: Project Narrative Occupational injuries and illnesses are significant public health problems, resulting in substantial human and economic costs. The initiatives outlined in this proposal by CSTE will enable state, local, tribal and territorial jurisdiction to increase their capacity to collect, analyze surveillance data on work-related injuries and illnesses across all NORA sectors and cross sectors. Enhanced surveillance systems will allow jurisdictions to more effectively identify and prevent work-related injuries and illness, thereby improving the health and safety in workplaces across the U.S.

PI_NAMEs: ROSENMAN, KENNETH D (contact)

PROJECT_TITLE: Enhancing State, Local, Tribal, Territorial Occupational Safety and Health Surveillance, Collaboration, Education, and Translation to Reduce Worker-Relation Injury and Ilness


FUNDING_MECHANISM: OTHERS

ORG_CITY: AUSTIN

ORG_NAME: TEXAS STATE DEPT OF HEALTH SERVICES

PHR: PROJECT NARRATIVE States can provide data from case- and population-based surveillance and in-depth investigations of occupational injuries and illnesses and contribute to the national occupational safety health surveillance efforts. These data can help guide targeted intervention efforts to reduce and prevent work-related mortality and morbidity. Given more than 50% of Texas residents are employed, this will lead to overall improvement in population health.

PI_NAMEs: PATEL, KETKI  (contact)

PROGRAM_OFFICER_NAME: O'NEILL, EDUARDO

PROJECT_TITLE: Texas Occupational Safety and Health Surveillance- Fundamental Program


ORG_CITY: STONY BROOK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: PROJECT NARRATIVE SARS-CoV-2 infection causes potentially deadly disease called COVID-19, which has severely affected aging and vulnerable populations in the United States and around the world, possibly leading to serious long-term health effects among survivors. This research project aims to evaluate risk factors for COVID-19 severity and assess the long-term health outcomes of COVID-19 among World Trade Center responders – an aging population with high prevalence of pre-existing respiratory and pulmonary conditions, and occupational risk factors. The results of this study will inform targeted interventions to manage negative outcomes of COVID-19 among World Trade Center responders and will have broader implications by helping us understand the impact of genetic factors, toxic environmental exposures, occupational factors and pre-existing conditions on the course and long-term effects of COVID-19.

PI_NAMEs: LUFT, BENJAMIN J (contact)

PROJECT_TITLE: Severity and long-term health effects of COVID-19 among World Trade Center responders


ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Utilizing an extensive amount of qualitative and quantitative imaging, clinical, and functional data, the overall goal of this study is to characterize the transitions over time into chronic obstructive pulmonary disease (COPD) among former workers and volunteers at the WTC disaster site. Our multidisciplinary investigative team proposes to establish the quantitative computed tomography (QCT) characteristics that may differentiate WTC-related from non-WTC-related COPD, investigate characteristics and longitudinal lung function trajectories of WTC patients with pre-COPD, and investigate lung mechanical strain (LMS) as an early QCT marker of lung injury associated with chronic disease and accelerated longitudinal lung function decline.

PI_NAMEs: DE LA HOZ, RAFAEL E. (contact)

PROJECT_TITLE: Chronic Obstructive Pulmonary Disase in WTC Workers - Diagnoses and Transitions


ADMINISTERING_IC: CE

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Project Narrative The proposed research has enormous public health implications given the tremendous burden of child sexual abuse on social, emotional and physical well-being. Evidence-based primary prevention interventions to eliminate child sexual abuse are needed and this study has the opportunity to demonstrate the efficacy of the Health Relationships Project (HRP) that has been operating for over 30 years, in 30 U.S. states, elevating it to the echelon of evidence-based programming. The innovative and novel stepped wedge cluster randomized trial of HRP conducted in 16 high need Washington, DC public charter schools, carried out by a highly skilled academic/community-based partnership, will have the methodological rigor and community input to make contributions to the field about how to implement and sustain a highly regarded and feasible school-based primary prevention intervention for child sexual abuse.

PI_NAMEs: MOLNAR, BETH ELLEN (contact)

PROJECT_TITLE: CE21-006 - Evaluation of the school-based Healthy Relationships Project for primary prevention of child sexual abuse among children pre-K through 5th grade


ORG_CITY: FLUSHING

ORG_NAME: QUEENS COLLEGE

PHR: The main goal of the proposed study is to provide guidance for whether effective treatment for PTSD would aid in the prevention of cardiovascular disease (CVD), a leading cause of death. Its innovative aspects are a) a consideration of the influence of cumulated symptoms of PTSD over time (PTSD “dose”) in relation to cardiovascular disease risk in the full cohort; b) the ability to stratify theses analyses by race/ethnicity, and c) an examination of the association between PTSD dose and behavioral and biological, and trauma history plausibility markers of stress and CVD risk in a subsample of the cohort.

PI_NAMEs: MORABIA, ALFREDO  (contact)

PROJECT_TITLE: Association of PTSD dose with cardiovascular disease risk in multi-ethnic WTC Heart Cohort: 13 year follow up


ADMINISTERING_IC: EY

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: NEUROSCIENCES

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Photoreceptor dystrophies and age-related macular degeneration cause permanent loss of cone photoreceptors and lead to blindness, but there are few to no treatment options for these diseases. In fish and amphibians, Müller glia cells in the retina proliferate in response to retinal damage, and their daughter cells differentiate to replace lost retinal neurons. In this project, I propose to use AAV technology to overexpress genes that promote early-stage retinal progenitor cell identity and repress genes associated with Müller glia cell identity, which may induce adult mouse Müller glia to proliferate and produce new cone photoreceptors.

PI_NAMEs: PANNULLO, NICOLE  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Address;adeno-associated viral vector;Adult;Advanced Development;Age related macular degeneration;Amphibia;ATOH7 gene;Blindness;Cell Differentiation process;cell type;Cells;combinatorial;Competence;competence factor;Data;daughter cell;Development;Disease;Dominant-Negative Mutation;Electroporation;Fishes;Gene Expression Profile;gene repression;gene therapy;Generations;Genes;Gliosis;Immunohistochemistry;In Situ;Individual;Injury;innovation;Length;loss of function;Mammals;Mediating;Muller's cell;multiple omics;Mus;N-Methylaspartate;Neonatal;novel;novel therapeutics;overexpression;Phenotype;Photoreceptors;postnatal;prenatal;Process;Production;progenitor;programs;Proliferating;Reagent;Repression;response;Retina;Retinal Cone;retinal damage;retinal neuron;retinal progenitor cell;Retinitis Pigmentosa;selective expression;single-cell RNA sequencing;Specific qualifier value;Stargardt's disease;Technology;Testing;Time;transcription factor;transcription regulatory network;Vision

PROJECT_TITLE: AAV-mediated Müller glia reprogramming to early-stage retinal progenitor cells


ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative In this proposal, we will study the role of an antigen specific CD8 regulatory T cell subtype, restricted to HLA-E, in controlling kidney transplant rejection. We will study in particular its role in suppressing T follicular helper cells and donor specific antibody generation in kidney transplantation. If successful, these studies will provide proof-of-concept data for application of CD8 Treg-based therapy to the clinical problem of kidney transplantation.

PI_NAMEs: AZZI, JAMIL  (contact);CANTOR, HARVEY

PROGRAM_OFFICER_NAME: KEHN, PATRICIA J

PROJECT_TERMS: Acceleration;Agonist;Alleles;Allogenic;allograft rejection;Allografting;Antibody Formation;Antibody Response;Antibody Therapy;antibody-mediated rejection;antigen test;antigen-specific T cells;Antigens;Autoimmunity;B cell differentiation;B-Lymphocytes;Binding;Biology;Blocking Antibodies;CD4 Positive T Lymphocytes;CD44 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Maturation;Cell Proliferation;Chronic;Clinical;clinical translation;clinically relevant;clinically significant;Clustered Regularly Interspaced Short Palindromic Repeats;Complement Activation;complement C4d;Complex;Data;defined contribution;Deposition;Development;donor-specific antibody;E protein;Generations;Genes;Genetic;Genetic Polymorphism;Graft Rejection;Graft Survival;Helper-Inducer T-Lymphocyte;Human;IL2RB gene;Immune response;improved;in vivo;Infection;Injury;isoimmunity;Kidney;kidney allograft;Kidney Transplantation;KLRA1 gene;Knock-in Mouse;Knockout Mice;Laboratories;Lymphocytic choriomeningitis virus;Mediating;Modeling;mouse model;Mus;Mutagenesis;Mutant Strains Mice;Natural Killer Cells;new therapeutic target;novel;novel strategies;Outcome;pathogen;Patients;peptide vaccination;Peptides;Point Mutation;Production;Proliferating;Publishing;Qa-1 Antigen;receptor;Regimen;Regulatory T-Lymphocyte;Reporting;Research;response;Role;Signal Transduction;Specificity;Stress;Structure of germinal center of lymph node;Study models;Surface;System;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;TCR Activation;Testing;Time;Tissue Grafts;tool;Transgenic Mice;translatable strategy;translational potential;transplant model

PROJECT_TITLE: The novel role of HLA-E restricted CD8 regulatory T cells in kidney allograft rejection

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Services;Networking and Information Technology R&D (NITRD);Patient Safety;Substance Misuse

ORG_CITY: TEMPE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: NARRATIVE This research is relevant to the public health because addiction treatment is at a crossroads, seeking a balance between protecting the privacy needs of patients with substance use disorder (SUD) and increasing patient safety through data access. This is the first study to integrate patient and health provider perspectives, interdisciplinary research and mixed methods to produce and evaluate generalized insights and strategies for sensitive SUD medical record sharing to improve health and health care for those with SUD. SHARES introduces novel, standard-based, institution-independent, EHR-agnostic and scalable sensitive health data segmentation methods and technology to improve data sharing and interoperability between healthcare organizations and service delivery and patient outcomes for those with SUD.

PI_NAMEs: GRANDO, MARIA ADELA (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: addiction;Adopted;Advocate;automated segmentation;Award;care delivery;Caring;Clinic;Clinical;Clinical Treatment;Clinical Trials Network;Collaborations;Communication;Computer software;Data;data access;data interoperability;data privacy;Data Protection;data sharing;Diagnosis;Drug abuse;Effectiveness;Electronic Health Record;Emergency department visit;Equilibrium;Ethics;Evaluation;Focus Groups;follow-up;Health;health care service organization;health data;Health Personnel;health plan;health record;Health system;Healthcare;Healthcare Systems;Hydrocodone;improved;Informatics;insight;Institution;integrated care;Interdisciplinary Study;International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10);interoperability;Knowledge;Language;Laws;Legal;Literature;Manuals;Marijuana Dependence;Medical;Medical Records;Medicine;Mental Health;Methods;Modeling;novel;novel strategies;Opioid;Outcome;Patient Data Privacy;patient engagement;patient oriented;Patient Preferences;patient safety;Patient-Focused Outcomes;Patients;Performance;Pharmaceutical Preparations;Policies;preference;Privacy;privacy protection;Procedures;Process;Provider;Public Health;Publications;Qualitative Research;Quality of Care;Recommendation;Recording of previous events;Research;service delivery;Site;social stigma;Spanish;Spanish/English;Standardization;substance use;Substance Use Disorder;Surveys;Technology;Terminology;Testing;tool;United States Substance Abuse and Mental Health Services Administration;Voice;willingness

PROJECT_TITLE: SHARES: Substance use HeAlth REcord Sharing

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: DURHAM VA MEDICAL CENTER

PHR: Tinnitus (“ringing in the ears”) has long been a problem for Veterans. The problem continues to escalate due to high levels of noise in the military, and because tinnitus often is associated with traumatic brain injury and post- traumatic stress disorder. In spite of limited research support, sound-based (acoustic) therapies are most often used for tinnitus intervention, and increasing numbers of commercial devices are becoming available that offer various acoustic-stimulus protocols. The proposed study will provide evidence from a randomized controlled trial comparing effects of acoustic-stimulus methods that are purported to suppress tinnitus and/or reduce its functional effects. The study will focus on methods with the strongest scientific rationale, i.e., noise that is notched around the predominant tinnitus-frequency region. Special ear-level devices will deliver these acoustic-therapy protocols that are purported to modify tinnitus-related neural activity. The study will follow a study recently completed by the applicant that provides preliminary evidence supporting this method.

PI_NAMEs: QUINN, CANDICE MANNING (contact)

PROJECT_TERMS: Acoustics;Adopted;Aftercare;Area;Attention;Auditory;Auditory Evoked Potentials;Behavioral;career;Caring;catalyst;Central Nervous System;Chronic;Clinical;Development;Devices;disability;Ear;efficacy evaluation;Electroencephalography;Electrophysiology (science);emotional distress;Enrollment;Evaluation;evidence base;Evidence based treatment;Exhibits;experience;Foundations;Frequencies;Goals;habituation;Hearing Aids;hearing impairment;help-seeking behavior;Hour;Immersion;improved;indexing;Individual;insight;instrument;Intervention;Lateral;Loudness;Loudness Perception;Maintenance;Marketing;Measures;Methods;Military Personnel;military veteran;neural;neurophysiology;Noise;notch protein;Outcome;Outcome Assessment;Outcome Measure;Participant;patient oriented;Patient Self-Report;Patients;Perception;Physiological;Post-Traumatic Stress Disorders;Process;programs;Protocols documentation;Psychoacoustics;Randomized;Randomized, Controlled Trials;Reaction;Research;Research Support;sensory gating;Services;Severities;Sleep disturbances;Solid;sound;Stimulus;theories;Therapeutic Intervention;therapy development;Tinnitus;tool;Training;Training Programs;Traumatic Brain Injury;treatment center;treatment duration;trial comparing;Veterans;whole health;Work

PROJECT_TITLE: Notched Noise Therapy for Suppression of Tinnitus: A Randomized Controlled Trial

STUDY_SECTION_NAME: Career Development Program - Panel II[RRD9]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: MADISON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Narrative Being able to characterize the impact of genetic variants on phenotypes is critical for interpreting the roles these variants play in human health and disease. The proposed research will significantly advance our ability to predict the impact of genetic variants thereby boosting the effectiveness of genomic analyses ranging from genome-wide association studies for common diseases to diagnostic odysseys searching for genetic causes of rare diseases.

PI_NAMEs: CRAVEN, MARK W. (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: Active Learning;Address;Benchmarking;Biological;Catalogs;causal variant;Clinical;Clinical assessments;Code;Communities;Creativeness;Data;Data Collection;data integration;Data Set;deep learning;deep neural network;design;Diagnostic;Disease;disease diagnosis;disease phenotype;diverse data;Effectiveness;Elements;experimental study;Gene Expression;gene function;gene product;Genes;Genetic;genetic variant;Genetic Variation;Genome;genome wide association study;genomic variation;Genomics;Genotype;Health;Human;improved;Individual;insight;interest;Knowledge;Learning;learning algorithm;learning network;learning strategy;Link;Machine Learning;Methodology;Methods;Modeling;Molecular;Molecular Profiling;molecular scale;Organism;Outcome;Pathway interactions;Penetrance;Phenotype;Play;predictive modeling;Prognosis;Rare Diseases;rare variant;Research;Resolution;response;Role;Series;Technology;Testing;Training;Validation;Variant;Work

PROJECT_TITLE: Linking Variants to Multi-scale Phenotypes via a Synthesis of Subnetwork Inference and Deep Learning


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Disability Research;Machine Learning and Artificial Intelligence;Neurosciences;Rehabilitation;Stroke

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative Aphasia (acquired language impairment) is one of the most common consequences of stroke and often leads to significant long-term disability. This project seeks to better characterize the neural correlates of recovery from aphasia after stroke, and to determine which patterns of functional reorganization are associated with more or less favorable language outcomes. A better understanding of the biological mechanisms that underlie recovery from aphasia will contribute to the development of neuromodulatory and therapeutic interventions, and will improve the clinical management of individuals with aphasia.

PI_NAMEs: DE RIESTHAL, MICHAEL R (contact);WILSON, STEPHEN M

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Acute;acute stroke;Address;Aphasia;aphasia recovery;Area;Behavior Therapy;Biological;Brain region;Chronic;Chronic Phase;chronic stroke;Clinical;Clinical Data;clinical infrastructure;Clinical Management;Cognitive;cohort;Complement;Complex;Development;Equation;Evaluation;experience;follow-up;Functional Imaging;Goals;high dimensionality;Image;improved;Individual;innovation;Intervention;Knowledge;Language;Language Development;Language Disorders;language impairment;language outcome;language processing;Left;Lesion;Location;Long term disability;Longitudinal Studies;machine learning algorithm;Magnetic Resonance Imaging;Maps;Measures;Modeling;multimodality;neural correlate;neuroimaging;Neuronal Plasticity;neuroregulation;Outcome;Participant;Patients;Pattern;Performance;Persons;Phase;post stroke;predictive modeling;Process;Prognosis;Protocols documentation;Recovery;recruit;Rehabilitation therapy;Reproducibility;Research;Resolution;Resources;Role;Sample Size;Sampling;Site;Stimulus;Stroke;stroke patient;support vector machine;Task Performances;Testing;Therapeutic Intervention;Time;Tissue Survival;Validity and Reliability;Work

PROJECT_TITLE: Neural Correlates of Recovery from Aphasia After Stroke

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Narrative This proposal will elucidate how excessive free hemoglobin in circulation binds to von Willebrand factor (VWF) and alters the interaction between VWF and fibrinogen at very high flow conditions. This project will also characterize the function of VWF derived from platelets in the presence of elevated levels of hemoglobin. The proposed work will lay the foundation for the development of anti-thrombotic agents targeting the VWF-hemoglobin interaction.

PI_NAMEs: CRUZ, MIGUEL ANGEL (contact);YEE, ANDREW

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: Adhesions;Adsorption;age group;Antibodies;Anticoagulation;Avidity;Binding;Biochemical;Blood;Blood Platelets;Circulation;Coagulation Process;Complex;Complication;Cryoelectron Microscopy;Death Rate;Development;Devices;enhancing factor;Environment;Exposure to;Extracorporeal Membrane Oxygenation;Fibrin;Fibrinogen;Fibrinolytic Agents;Formalin;Foundations;Glycoproteins;Hemoglobin;Hemoglobin A;Hemoglobin concentration result;Hemolysis;Hemolysis Induction;Hemorrhage;Hemostatic Agents;Hemostatic function;Intervention;Investigation;Measures;mechanical circulatory support;Mediating;Molecular;Molecular Conformation;Monitor;Mus;novel therapeutic intervention;Organ;Outcome;Pathology;Patients;Plasma;Process;Proteins;Publishing;Reaction;Recombinant Proteins;Reporting;Risk;Risk Factors;Role;shear stress;Surface;surface coating;targeted agent;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Thrombosis;thrombotic;thrombotic complications;Thrombus;Variant;ventricular assist device;Visualization;von Willebrand Disease;von Willebrand Factor;von Willebrand factor receptor;Whole Blood;Work

PROJECT_TITLE: Molecular Studies of Hemolytic Thrombosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-C(02)M]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Newark

ORG_DEPT: PEDIATRICS

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Children from low-income Latino backgrounds are at elevated risk for delays in language and social-emotional skill acquisition that negatively impact school readiness and perpetuate existing health disparities. Primary care is an innovative, near-universal platform for preventive parenting interventions like literacy promotion a pediatric care standard that can help mitigate these disparities. The current proposal tests novel approaches to literacy promotion that have the potential to change the way primary care interventions are designed and implemented to promote equity in developmental health and school readiness.

PI_NAMEs: JIMENEZ, MANUEL E (contact)

PROGRAM_OFFICER_NAME: KING, TRACY

PROJECT_TERMS: Academy;Address;arm;Behavior;Books;care coordination;Case Management;Child;Child Development;Child Health;Child health care;Child Language;Child Rearing;Childhood;Clinic;Clinic Visits;Collaborations;Communities;Cues;Data;design;Development;Developmental Delay Disorders;Disparity;disparity reduction;Dissemination and Implementation;early childhood;economic disparity;Emotional;Ensure;Environment;Equity;Ethnic Origin;evidence base;experience;Family;Food;Frequencies;Future;Health;Health behavior;health disparity;Hearing;Home;Housing;Improve Access;improved;Income;infancy;innovation;Intake;Intention;Intervention;intervention effect;Interview;Knowledge;Language;Language Development;Latino;Life;literacy;Literature;Low income;lower income families;Maternal and Child Health;Mediating;Methods;Modeling;National Institute of Child Health and Human Development;Neighborhood Health Center;novel strategies;Outcome;outreach;parenting intervention;Parents;Poverty;poverty alleviation;poverty reduction;Preventive;Primary Care;process evaluation;programs;Randomized;randomized, clinical trials;Readiness;Reading;recruit;Reporting;Research;Resources;response;Risk;Schools;Services;skill acquisition;skills;social;standard of care;Stress;stressor;Surveys;Testing;Text Messaging;theories;therapy design;Work

PROJECT_TITLE: Addressing Disparities in Language and Social-emotional Skill Acquisition through Literacy Promotion in Primary Care

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Food Allergies;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Pediatric

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because children's food allergies are on the rise as are major efforts to develop safe and effective therapies to treat them. The book resulting from this research will critically examine how stakeholders, especially parents, clinicians, and researchers, perceive the risks and benefits of these treatments. Findings from the project could inform guidelines about how parents should be informed about the risks and benefits of FDA-approved, investigational, and unregulated treat- ment options for their children's food allergies.

PI_NAMEs: FISHER, JILL A (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Accidents;Adolescent;Advocate;Affect;aged;Allergens;Allergic;Allergy to peanuts;American;Benefits and Risks;Biomedical Research;Black race;Books;Cessation of life;Child;Childhood;Clinic;clinical practice;Clinical Trials;Data;Development;effective therapy;Empirical Research;Enrollment;Ethnic Population;Ethnography;experience;Family;Food;food allergen;food avoidance;Food Hypersensitivity;Funding;Grant;Guidelines;Health;Hypersensitivity;innovation;interest;Interview;Investments;lens;Life;Literature;Low income;Magic;Manuscripts;Marketing;Medical;Modeling;novel therapeutics;Parents;Pathway interactions;Patients;Perception;Pharmaceutical Preparations;Pharmacologic Substance;Powder dose form;Private Practice;Privatization;Protocols documentation;Public Health;Qualifying;Quality of life;racial population;Reaction;recruit;Reporter;Research;research and development;Research Personnel;Risk;risk perception;Safety;Sales;Sampling;Social Sciences;Stress;Structure;Therapeutic;Therapeutic Intervention;treatment comparison;Treatment/Psychosocial Effects;Underrepresented Minority;United States;United States Food and Drug Administration;United States National Institutes of Health;urban area;Work;Writing

PROJECT_TITLE: Challenging Allergies: The Search for a Magic Bullet for Pediatric Food Allergies


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Prevention;Social Determinants of Health;Vaccine Related

ORG_CITY: PITTSBURGH

ORG_NAME: VETERANS HEALTH FOUNDATION

PHR: Our project will answer crucial questions about the real-world effectiveness of novel oral antiviral agents against COVID-19 in specific high-risk populations. These agents have received Emergency Use Authorization but have not yet been fully approved by the Food and Drug Administration. It is critical to assess their effect on specific high-risk populations and understand their role in the management of COVID-19 in the real-world setting.

PI_NAMEs: BUTT, ADEEL A (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Acute myocardial infarction;Address;Affect;Ambulatory Care Facilities;Anti-viral Agents;Authorization documentation;booster vaccine;breakthrough infection;Cardiovascular system;Caring;Case Study;Cessation of life;Characteristics;Clinic Visits;Clinical;clinical investigation;clinical practice;Collaborations;Communicable Diseases;comorbidity;comparative effectiveness;COVID-19;Data;data sharing networks;data warehouse;Databases;demographics;Diabetes Mellitus;Diagnosis;Disease;Disparity;Early treatment;Effectiveness;effectiveness evaluation;effectiveness study;Emergency department visit;Emergency Situation;Endocrine system;epidemiology study;ethnic minority status;Event;evidence base;experience;FDA Emergency Use Authorization;gastrointestinal;Geographic Locations;Grant;health care service utilization;Hepatic;high risk;high risk population;Homelessness;Hospitalization;Immunity;Incidence;Institutional Review Boards;Internal Medicine;International;Journals;Kidney;Knowledge;Laboratories;Medical;Medicine;Mental disorders;Metabolic;molnupiravir;mortality;Natural History;Nature;New Agents;New England;nirmatrelvir;novel;Older Population;Oral;Outcome;Paper;Patients;Peer Review;Persons;Pharmaceutical Preparations;pharmacologic;physically handicapped;Policy Maker;Population;Poverty;prevent;progression risk;Provider;public health emergency;Publications;Publishing;racial minority;Recovery;Renal function;Reporting;residence;respiratory;Ritonavir;Role;SARS-CoV-2 infection;Severities;social vulnerability;Source;Stroke;Therapeutic Agents;Time;United States Department of Veterans Affairs;United States Food and Drug Administration;Update;Vaccination;Vaccinee;Vaccines;Variant;Vulnerable Populations

PROJECT_TITLE: Oral Antivirals against COVID-19 and Clinical Outcomes in High Risk Populations

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Hypertension;Kidney Disease;Patient Safety

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE Heart failure affects 5.7 million people in the United States, and approximately one-half of patients with heart failure die within five years of diagnosis. A novel drug that combines the heart medicine valsartan (an angiotensin receptor blocker) with a new type of medicine called a neprilysin inhibitor reduces death in patients with heart failure, but its use has been limited by side effects such as low blood pressure and we do not fully understand how it works. The purpose of this grant is to determine whether this combined angiotensin receptor blocker/neprilysin inhibitor acts by increasing the actions of specific chemicals in the body (bradykinin, substance P, and brain natriuretic peptide) so that we can optimize the use of this medication while minimizing side effects and potentially identify new drug strategies to reduce the burden of heart failure.

PI_NAMEs: BROWN, NANCY J. (contact);STEVENSON, LYNNE W

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: Acute;Adrenergic beta-Antagonists;Adverse effects;Affect;Alteplase;Aminopeptidase P;Angioneurotic Edema;Angiotensin I;Angiotensin II;Angiotensin Receptor;Angiotensin-Converting Enzyme Inhibitors;antagonist;Anti-diabetic Drugs;aprepitant;Atrial Natriuretic Factor;Biological Assay;Blood flow;Blood Pressure;blood pressure reduction;Bradykinin;Bradykinin B2 Receptor;Brain natriuretic peptide;C-Type Natriuretic Peptide;cardiovascular pharmacology;Catecholamines;Cessation of life;Chemicals;Clinical;clinical practice;Complex;Congestive Heart Failure;Diabetes Mellitus;Diagnosis;Dipeptidyl Peptidases;Diuresis;Diuretics;Dose;Drug Interactions;Eligibility Determination;Enalapril;Endothelin;Endothelium;experience;FDA approved;Fiber;Fibrinolysis;Forearm;Gender;Grant;Heart;Heart failure;heart failure with reduced ejection fraction;hemodynamics;hospital readmission;Hospitalization;Hypotension;Hypotensives;icatibant;Immunoassay;improved;individual patient;inhibitor;Investigational Drugs;Kidney;Kidney Failure;Label;Life Expectancy;Measures;Medicine;Mineralocorticoid Receptor;Molecular;Morbidity - disease rate;mortality;Natriuresis;Natriuretic Peptides;Neprilysin;novel;novel drug class;novel drug combination;novel therapeutics;Patients;peptide P;Peptides;Peptidyl-Dipeptidase A;Persons;Pharmaceutical Preparations;Prevalence;prevent;pro-brain natriuretic peptide (1-76);Prodrugs;prospective;Race;randomized, clinical trials;receptor;Receptor, Angiotensin, Type 1;Renin-Angiotensin-Aldosterone System;Research;response;saluretic;Sensory;side effect;Substance P;TACR1 gene;Testing;Titrations;Treatment Failure;United States;valsartan;Vascular Permeabilities;Vasodilation;Vasodilator Agents;Work

PROJECT_TITLE: Mechanism(s) Underlying Hypotensive Response to ARB/NEP Inhibition

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Sex differences in brain structure and sex-biased penetrance of neurodevelopmental disorders have long been appreciated, where X chromosome gene dosage contributes to sex-specific developmental programs. This project seeks to characterize how X-linked gene dosage leads to sex-dimorphic responses to retinoic acid during development, contributing to sex-specific vulnerabilities to neurological disorders. This work will provide important insights into the genes that lead to disparate developmental phenotypes in response to retinoic acid, providing insight into the etiology of neurodevelopmental disorders and uncovering possible targets for therapeutic interventions.

PI_NAMEs: HENNICK, KELSEY  (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Address;Anatomy;Anterior;autism spectrum disorder;Basic Science;Biological Assay;Biomedical Research;Brain;cell type;Central Nervous System;CRISPR interference;Data;Data Set;demethylation;Development;differential expression;Disease;Disparate;dosage;Enhancers;Enzymes;Epigenetic Process;Etiology;Exhibits;experimental study;Exposure to;Female;FOXP1 gene;Fragile X Syndrome;Gene Dosage;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;genome-wide;Genomics;Glutamates;Gonadal Steroid Hormones;gray matter;histone modification;Histones;Human;human female;human induced pluripotent stem cells;Immunohistochemistry;In Vitro;Incidence;insight;KDM5B gene;knock-down;Lead;Link;Lysine;male;Mediating;Methylation;Modeling;Molecular;morphogens;Mutation;nervous system development;Nervous System Disorder;neurodevelopment;Neurodevelopmental Disorder;Neurons;Organoids;Pattern;Penetrance;Phenotype;Prefrontal Cortex;programs;receptor function;response;Retinoic Acid Receptor;retinoic acid receptor alpha;Rett Syndrome;risk variant;RORA gene;Sampling;sex;Sex Bias;Sex Chromosomes;Sex Differences;sexual dimorphism;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;stem cell differentiation;stem cell organoids;stem cells;Structure;targeted treatment;Testing;therapeutic candidate;Therapeutic Intervention;Tissues;transcription factor;Transcription Initiation;Transcriptional Regulation;Tretinoin;Up-Regulation;Vitamin A;Work;X Chromosome;X Inactivation

PROJECT_TITLE: Characterizing the mechanistic basis for sex-dimorphic responses to retinoic acid signaling in the developing brain


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative. This R01 study will advance our understanding of the neurobiological impact of early life stress and its impact on risk of psychopathology during the neurodevelopmentally sensitive period of early childhood. Our neurobiological and developmental model will help identify biological profiles that signal risk during a period of heightened brain plasticity and will ultimately guide novel treatment approaches aimed at intervening on early biological changes before they translate into behaviors and psychopathology.

PI_NAMEs: MELHEM, NADINE M.;PERLMAN, SUSAN B (contact)

PROGRAM_OFFICER_NAME: ZEHR, JULIA L

PROJECT_TERMS: Adolescence;Adult;Affect;Age;aged;Amygdaloid structure;Animals;Area;Behavior;Behavioral;Biological;biological adaptation to stress;biological systems;Brain;Caregivers;caregiving;Cessation of life;Child;Chronic;Chronic stress;comparison control;Conflict (Psychology);Development;Divorce;Down-Regulation;early childhood;early life stress;Emotional;Environment;Exposure to;Family;Family Process;Foundations;Frequencies;Hair;Hippocampus;Human;Hydrocortisone;Hyperactivity;hypothalamic-pituitary-adrenal axis;improved;Institutionalization;Intake;Intervention;Magnetic Resonance Imaging;Measures;Mediating;Mental disorders;Mental Health;middle childhood;Modeling;neural;neural circuit;Neurobiology;neurodevelopment;Neuronal Plasticity;novel;Outcome;Parent-Child Relations;Parents;Pathway interactions;Patient Self-Report;peer;Peripheral;Population;Prevention;psychiatric symptom;Psychological Stress;Psychopathology;Race;Recording of previous events;recruit;Reporting;Research;response;Risk;Role;Salivary;sex;Signal Transduction;Socioeconomic Status;Stress;Stressful Event;stressor;Symptoms;System;teacher;Temperament;Time;Translating

PROJECT_TITLE: Biological Substrates of Maladaptive Stress Response in Early Childhood


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Substance Misuse;Transplantation

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

PHR: PROJECT NARRATIVE A major hurdle in developing effective neurological treatments has been translation of scientific discoveries from rodent models to humans. To close this critical translational gap, we will use pluripotent stem cell-, CRISPR/Cas9-based gene editing-, male germ line-, 3D organoid-, and marmoset tissue-derived-tools to explore ARX-associated mutations linked to brain cortex malformation, epilepsy, and intellectual disability. The overarching goals of this project are to develop a marmoset model system to represent the neurobiology of the human brain and to develop a novel pluripotent stem cell/male germline-mediated transgenesis approach to advance the utility of the marmoset model to benefit the brain health research community.

PI_NAMEs: HERMANN, BRIAN PETER (contact);HSIEH, JENNY ;MCCARREY, JOHN R;NAVARA, CHRISTOPHER

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: 3-Dimensional;Address;Adult;Affect;Alleles;Allogenic;Anatomy;Animals;Area;Behavioral Assay;Biological Models;bisulfite sequencing;Brain;Brain Diseases;brain health;brain research;Breeding;Callithrix;Callithrix jacchus jacchus;cell cortex;Cell Transplantation;cell type;Cells;Chimerism;Chromatin;Clinic;clinical predictors;Clinical Trials;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;cognitive process;Communities;Complex;Cortical Malformation;CRISPR/Cas technology;Defect;Derivation procedure;design;Development;differentiation in vitro;disability;Disease;DNA Methylation;Embryo;Enterobacteria phage P1 Cre recombinase;Epigenetic Process;epigenomics;Epilepsy;experience;Failure;fetal;Fostering;Gene Expression;Gene Transfer Techniques;Genes;Genetic;Genome;genome editing;Germ Cells;Germ Lines;germline stem cells;Goals;Health;Histology;histone modification;Homeobox;Homeobox Genes;Human;human model;In Vitro;in vivo;induced pluripotent stem cell;infancy;Injections;innovation;innovative neurotechnologies;Intellectual functioning disability;interest;Interneurons;Knock-in;Knowledge;Laboratories;life span;Link;lissencephaly;Magnetic Resonance Imaging;male;Marketing;Mediating;Methodology;Methods;migration;Modeling;Modification;Mus;mutant;Mutation;Nervous System Disorder;neural;Neuroanatomy;Neurobiology;Neurodegenerative Disorders;neurogenetics;Neurologic;neuron development;Neurons;neuropsychiatric disorder;neuropsychiatry;Newborn Infant;non-invasive imaging;nonhuman primate;Normalcy;novel;novel strategies;novel therapeutics;offspring;Operative Surgical Procedures;Organoids;Pathway interactions;Pharmaceutical Preparations;Pluripotent Stem Cells;polyalanine;Population;postnatal;Pregnancy;Primates;Production;Protocols documentation;Publishing;reconstitution;Reporter;Research;Research Personnel;Rodent;Rodent Model;single cell genomics;single-cell RNA sequencing;skills;Source;sperm cell;Spermatocytes;Spermatogenesis;Study models;success;System;Testis;Therapeutic;therapeutically effective;therapy design/development;Tissues;tool;transcriptome sequencing;Transgenes;Transgenic Organisms;Translating;Translations;transmission process;Transplantation;United States National Institutes of Health;Validation;whole genome;Xenograft procedure

PROJECT_TITLE: Advancing brain health research through male germline editing in marmosets


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Pediatric

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative  Despite the high need for effective emotion regulation interventions in adolescents and the potential for peer relationships to improve emotion regulation in this age group, no research to date has examined whether peer-facilitated activation of neural reward circuitry can effectively regulate emotion in adolescence. The goal of this project is to test whether regulating emotions with help from a friend is more effective and long-lasting in adolescents than regulating alone, and to characterize age-related differences in the neural mechanisms supporting social versus cognitive emotion regulation. Examining the mechanisms underlying social emotion regulation in adolescents will advance our understanding of how social contexts shape adolescent brain development, and how peer influence can be applied towards improving adolescent health, laying the groundwork for positive emotional wellbeing into adulthood.

PI_NAMEs: EISENBERGER, NAOMI ILANA;LIEBERMAN, MATTHEW DYLAN;SILVERS, JENNIFER ASHLEY (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Adolescence;Adolescent;adolescent brain development;adolescent health;Adult;Age;age difference;age group;Amygdaloid structure;Behavior;Behavioral;Brain;Brain region;Buffers;Cognitive;cognitive control;cognitive reappraisal;Collection;Cues;Data;Decision Making;Development;Down-Regulation;efficacy evaluation;emotion dysregulation;emotion regulation;Emotional;Emotions;Event;experience;Frequencies;Friends;Functional Magnetic Resonance Imaging;Goals;improved;Intervention;Lateral;Link;National Institute of Child Health and Human Development;negative affect;neural;neurodevelopment;neuromechanism;novel;Pathway interactions;Patient Self-Report;peer;peer influence;Play;Prefrontal Cortex;recruit;Regulation;Research;reward circuitry;Rewards;Risk Behaviors;Role;scaffold;Shapes;showing emotion;social;Social Environment;Social Facilitation;social interventions;Source;Stimulus;success;Symptoms;Testing;therapy design;Time;Ventral Striatum;vulnerable adolescent;Well in self;Work

PROJECT_TITLE: Social Facilitation of Emotion Regulation in Adolescence

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Narrative LUBAC dysfunction has been found to be one of several underlying causes of primary immune deficiencies. Our proposed studies aim to understand the basic cellular mechanisms that protect cells from aberrant cell death and inflammation. This research will have the potential to positively impact our understanding of TNF signaling.

PI_NAMEs: LOPEZ-MOSQUEDA, JAIME  (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Alleles;Animals;Apoptosis;Automobile Driving;Biomedical Research;CASP1 gene;Cell Death;Cell Death Inhibition;Cell Survival;Cells;Cessation of life;Chronic;cohort;Collaborations;Complex;congenital immunodeficiency;cytokine;Cytoprotection;Decision Making;Etiology;Event;Functional disorder;Gene Activation;Gene Deletion;Genes;Genetic Transcription;Germ-Line Mutation;Goals;In Vitro;in vivo;Inflammation;Inflammatory;insight;Life;Mediating;Modification;Molecular;mouse model;Mus;mutant;NF-kappa B;Organ;Outcome;Pathway interactions;Patients;Phenocopy;Phenotype;Phosphorylation;Post-Translational Protein Processing;prevent;Prevention;Production;Proteins;Publishing;Research;Research Training;response;Role;Sepsis;sharpin;Signal Induction;Signal Transduction;Signaling Molecule;Site;systemic inflammatory response;Testing;Tissues;TNF gene;tool;Tumor Necrosis Factor Receptor;Ubiquitin;ubiquitin isopeptidase;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;Work

PROJECT_TITLE: Biomedical Research and Research Training

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Behavioral and Social Science;Mental Health

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Understanding development is critical for understanding psychopathology, particularly for identifying the precursors and early manifestations of illness. This postdoctoral training program, entering its 43rd year, focuses on training scientists in areas related to translational developmental neuroscience. The scientists trained by this program become leaders in identifying the child and adolescent causes of and precursors to mental illness, and in developing novel strategies for treatment and prevention.

PI_NAMEs: TREGELLAS, JASON R (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TITLE: Development of Psychopathology, Psychobiology, & Behavior


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Diabetes;Heart Disease;Heart Disease - Coronary Heart Disease;Nutrition;Obesity;Prevention;Regenerative Medicine

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: Project Narrative The fundamental processes of myocardial response to obesity and diabetes and the reasons for failed therapeutic clinical trials in patients with cardiac illness are currently unknown. We will combine multi-omics and physiological data to build the first comprehensive molecular portrait of cardiac mechanisms in response to metabolic syndrome, obesity, and treatment with sitagliptin and canagliflozin. We will identify critical pathways, molecular targets, and myocardial treatment options in patients with obesity and diabetes using our integrative approach and the pig model of cardiac disease.

PI_NAMEs: SELLKE, FRANK W (contact);USHEVA-SIMIDJIYSKA, ANNY

PROGRAM_OFFICER_NAME: KIRBY, RUTH

PROJECT_TERMS: Affinity;ameroid;angiogenesis;Animal Model;Animals;Area;Awareness;base;Binding;Blood Glucose;blood glucose regulation;Blood Pressure;Blood Vessels;Bypass;Calpain;Cardiac;cardioprotection;Cardiovascular Abnormalities;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular Physiology;Cell Culture Techniques;Cells;Chronic;Citric Acid Cycle;Clinical;Clinical Research;comparative;comparison control;Complex;Coronary Arteriosclerosis;Critical Pathways;Data;Data Analyses;density;Development;Diabetes Mellitus;Diet;dietary control;Diffuse;Disease;DNA;Dose;Drug Targeting;Ectopic Expression;effective therapy;enzyme activity;Equilibrium;Event;experimental study;Failure;Family suidae;Fatty acid glycerol esters;feeding;Female;Funding;Gender;Generations;Glucose;glycemic control;glycogen synthase kinase 3 beta;glycosylation;Goals;Grant;Growth;Heart Diseases;heart function;Hexosamines;High Fat Diet;Human;Hyperglycemia;Hypertension;Hypoglycemia;Image;Impairment;improved;In Vitro;in vivo;Inflammatory;Insulin;Insulin Resistance;insulin signaling;Ischemia;knock-down;Laboratories;Left;male;Metabolic;Metabolic Control;metabolic imaging;Metabolic Pathway;Metabolic syndrome;metabolomics;Metformin;Modeling;Modeling of Functional Interactions;Molecular;molecular modeling;Molecular Target;mortality;Multiomic Data;multiple omics;Myocardial;Myocardial Ischemia;Myocardial perfusion;Myocardial tissue;Myocardium;Natural regeneration;Non-Insulin-Dependent Diabetes Mellitus;obese patients;Obesity;Operative Surgical Procedures;overexpression;Pathway interactions;Patients;Perfusion;Physiological;PIK3CG gene;polyol;Population;porcine model;Portraits;Prevention strategy;primary endpoint;Process;promoter;protein expression;Proteins;Proteomics;Public Health;Publishing;Recommendation;Reporting;response;Risk;Risk Factors;Rodent Model;Role;Schedule;Small Interfering RNA;Specificity;Therapeutic;Therapeutic Clinical Trial;Therapy Clinical Trials;Thinness;tissue culture;Tissue Engineering;Tissues;Toxic effect;transcriptomics;treatment response;treatment strategy;Vascular Diseases;Vascular regeneration;Ventricular;YY1 Transcription Factor

PROJECT_TITLE: Vascular Dysfunction in Myocardial Ischemia and Metabolic Syndrome

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Regenerative Medicine

ORG_CITY: WYNNEWOOD

ORG_NAME: LANKENAU INSTITUTE FOR MEDICAL RESEARCH

PHR: Project Narrative Periodontal disease is the main cause of tooth loss and takes a significant toll on patient health in both young and old and has a major economic impact. Achieving regeneration of oral tissues such as bone and periodontal ligament that are affected by periodontal disease in aged individuals using a drug delivered from an injectable biomaterial would be of major importance in dental medicine and health in general.

PI_NAMEs: HAJISHENGALLIS, GEORGIOS ;HEBER-KATZ, ELLEN S. (contact);MESSERSMITH, PHILLIP B

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: Affect;aging population;Agonist;AMD3100;animal old age;antagonist;Anti-Inflammatory Agents;Biocompatible Materials;bioscaffold;bone;Bone Regeneration;Bone remodeling;Bone Tissue;Breeding;Cartilage;Cell Count;CXCR;CXCR4 gene;cytokine;Defect;Dental;design;Development;Disease;disease model;Distal;Dose;Drug Delivery Systems;Drug Modulation;Ear;economic impact;Evolution;experimental study;G-Protein-Coupled Receptors;Gel;Genetic Transcription;Grant;Hair follicle structure;healing;Health;human old age (65+);Hydrogels;Hypoxia Inducible Factor;Immune response;immunoregulation;In Situ;in vivo;Inflammation;Inflammatory;inhibitor;Injectable;Injections;Injury;Intervention;Jaw;juvenile animal;Laboratories;Lesion;Ligature;local drug delivery;Mammals;Mediating;Medicine;Messenger RNA;Metabolic;Modeling;Molecular;Mus;Mussels;Myeloid Cells;Natural regeneration;new therapeutic target;Newts;novel;novel therapeutics;old mice;oral tissue;Osteoblasts;PAR-1 Receptor;Pathway interactions;Patients;Peptides;Periodontal Diseases;Periodontal Ligament;Periodontitis;Pharmaceutical Preparations;Polyethylene Glycols;Polymers;Predisposition;Prevalence;Prodrugs;Proteinase-Activated Receptors;Proteins;regenerative;Regenerative response;regenerative therapy;Regulation;Regulatory T-Lymphocyte;Resolution;response;Role;self assembly;Series;Severities;Site;small hairpin RNA;small molecule;soft tissue;stem cell population;stem cells;subcutaneous;System;T memory cell;Testing;Thrombin;tissue regeneration;Tissues;Tooth Loss;trait;Translations;Up-Regulation;Work;wound healing;young adult

PROJECT_TITLE: New upstream targets for HIF-1a-mediated regeneration in young and aged animals

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE MicroRNAs and other types of non-coding RNAs have emerged as key regulators of gene expression, and errors in pathways controlled by these RNAs have been linked to numerous human diseases, including cancer, heart ailments and neurological disorders. This research program focuses on understanding how regulatory RNAs are expressed and function in the context of normal organismal development and in response to stressful conditions.

PI_NAMEs: PASQUINELLI, AMY E. (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Animals;Binding;Biochemical;Biogenesis;Biology;Caenorhabditis elegans;Complex;computational pipelines;Defect;design;Development;Disease;Foundations;Gene Expression;genomic data;Goals;Heart;Heat-Shock Response;human disease;in vivo;innovation;insight;Knowledge;Link;Malignant Neoplasms;Mediator;Methods;MicroRNAs;Modeling;Nervous System Disorder;novel;Organism;Pathway interactions;Phase;Play;Post-Transcriptional Regulation;programs;Recovery;Regulation;Regulator Genes;Research;Resources;response;RNA;Role;Stress;therapeutic RNA;Untranslated RNA

PROJECT_TITLE: Biogenesis and Function of Regulatory RNAs

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]