ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Rare Diseases

ORG_CITY: Loma Linda

ORG_DEPT: DENTISTRY

ORG_NAME: LOMA LINDA UNIVERSITY

PHR: PROJECT NARRATIVE This application responds to the PAR-22-131 RFA by validating a minimally invasive, robust, multi-stage artificial intelligence (AI)-based cytologic, histologic and epigenetic (multi-omic) biomarker to identify oral premalignant lesions (OPL) with high risk of progression to invasive oral cavity squamous cell carcinoma (OSCC). Our biomarker, named the PROSPECT score, will be validated in a massive data set and a prospective study in racially and socioeconomically diverse OPL patients. There is currently no reliable clinical, histologic or molecular marker to determine individual risk in patients with the same dysplasia grade. A reliable biomarker will optimize survival in patients by optimizing risk stratification of OPLs and encouraging closer surveillance of patients with high cancer transformation risk.

PI_NAMEs: AOUIZERAT, BRADLEY E;VIET, CHI T. (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: access restrictions;Accounting;Address;Agreement;American;Artificial Intelligence;Biological Markers;Biopsy;cancer diagnosis;cancer risk;Cessation of life;Clinical;Clinical Research;clinical research site;Clinical Trials;cohort;Collection;community setting;Computing Methodologies;cost;Cytology;Data;Data Set;Death Rate;deep learning;deep learning model;design;Development;Diagnosis;Diagnostic;Diagnostic tests;digital;digital pathology;Discipline;Disease;Dysplasia;epidemiologic data;epigenetic marker;Epigenetic Process;epigenomics;experience;Geography;Head and neck structure;health disparity;Health Services Accessibility;Hematoxylin and Eosin Staining Method;High grade dysplasia;high risk;Histologic;Histology;Hour;Image;imaging biomarker;improved;indexing;Individual;Institution;International;Intervention;Lesion;Location;Longitudinal cohort;Malignant - descriptor;Malignant Neoplasms;Methods;Microscopy;minimally invasive;Modeling;Molecular;molecular marker;Monitor;Morbidity - disease rate;mouth squamous cell carcinoma;multimodality;multiple omics;Names;novel;Operative Surgical Procedures;Oral;oral dysplasia;oral lesion;Oral mucous membrane structure;Outcome;participant enrollment;Pathologist;Pathology;patient population;Patients;Pattern;Phenotype;Population;Population Heterogeneity;predictive modeling;predictive tools;premalignant;Prognosis;Prognostic Marker;prognostic value;prognostication;progression risk;prospective;Prospective cohort;Prospective Studies;Race;racial diversity;Recommendation;recruit;Resources;Retrospective cohort;Risk;Risk Assessment;risk prediction;risk stratification;Sampling;Scheme;Series;Site;Slide;social disparities;socioeconomic disparity;socioeconomics;Stains;Standardization;Stratification;Surgeon;Swab;Testing;Tissue Sample;Tissues;tool;Training;tumor progression;Validation

PROJECT_TITLE: PROSPECT: Premalignant Oral Lesions Pathology and Epigenetic Risk Prediction Tool

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


ADMINISTERING_IC: ES

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Breast Cancer;Cancer;Endocrine Disruptors;Estrogen;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lead Poisoning;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: CHICAGO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE Heavy metal pollution by arsenic (iAs) and lead (Pb) disproportionally affects low income communities and minority groups nationally and internationally. We found that these metals alone and in combination, at doses much lower than the World Health Organization (WHO) recommended limits, promote the reprogramming of treatment responsive ER+/PR+ breast cancer to ER+/PR- treatment refractory disease. As nuclear ROS were found to be mechanistically linked to PR downregulation this project proposes to test new and existing strategies based on organelle-targeted ROS scavengers as adjuvant therapeutics to restore treatment efficacy thereby providing short term pharmacologic solutions for patients impacted by socioeconomic and environmental health disparities.

PI_NAMEs: BONINI, MARCELO G. (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Address;Adjuvant;Adjuvant Therapy;Affect;Air Pollution;Alanine;Antineoplastic Agents;Antioxidants;Arsenic;Arsenites;authority;Automobile Driving;Biosensor;Breast Cancer Cell;Breast Cancer Patient;cancer cell;Cell Nucleus;cell transformation;Cells;Chemoresistance;chemotherapy;Chronic;Clinical;Communities;cost;Diagnosis;Disease;Dose;Down-Regulation;Environmental Exposure;Environmental Health;environmental health disparity;Environmental Impact;Epigenetic Process;Estrogen Receptors;Evolution;Exposure to;FDA approved;Gene Expression;gene network;Genes;Genetic;Goals;Health;Heavy Metals;in vivo;International;intravital microscopy;Lead;lead exposure;lead ion;Lead levels;Link;Low income;Maintenance;Malignant Breast Neoplasm;Mammary Neoplasms;Metals;Metastasis Induction;Metastatic/Recurrent;Minority;Minority Groups;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Molecular Profiling;Morbidity - disease rate;mortality;mouse model;Neoplasm Metastasis;neoplastic cell;novel;Nuclear;Organelles;Organoids;Oxidases;Oxidation-Reduction;Particulate;Patients;pharmacologic;Phenotype;pollutant;Pollution;prevent;Production;Progesterone;progesterone receptor positive;Progesterone Receptors;Prognosis;prognostic;Reactive Oxygen Species;Receptor Signaling;Recommendation;Refractory;Refractory Disease;Resistance;Risk;Selective Estrogen Receptor Modulators;Signal Transduction;Site;socioeconomics;Specific qualifier value;System;Tamoxifen;Testing;Therapeutic;therapy design;transcriptome sequencing;transcriptomics;Treatment Effectiveness;Treatment Efficacy;treatment response;treatment strategy;tumor;Tumor Cell Nuclei;tumor xenograft;Water Supply;women's treatment;World Health;World Health Organization;Xenograft procedure

PROJECT_TITLE: Suppression of progesterone receptor signaling by heavy metals promotes tamoxifen resistance and metastasis or ER+ breast cancer

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PHR: NARRATIVE As we age, our cells begin losing the ability to properly respond to environmental or genetic stresses, decreasing cell viability while increasing the likelihood of developing age-related diseases such as Alzheimer’s, Parkinson’s, or Huntington’s. Here, we will study one of the critical cellular pathways that is involved in helping a cell recover from stress, pinpointing the critical signaling factors that enable the cell to return to a healthy state. The molecular definitions resulting from this work will provide an atomic-level roadmap for the development of targeted therapeutics aimed at treating age-related diseases.

PI_NAMEs: LANDER, GABRIEL C (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Age;age related;Age related pathologies;age-related disease;Aging;Alzheimer's Disease;Alzheimer's disease patient;Amyotrophic Lateral Sclerosis;Binding;Biochemical;biological adaptation to stress;Biological Assay;Biophysics;Brain;Brain Diseases;C-terminal;Cell Survival;Cells;Cellular Assay;Cellular Stress;Coiled-Coil Domain;Complex;coping;Cryoelectron Microscopy;Crystallography;Cytosol;Development;Diagnosis;Dimerization;Double-Stranded RNA;EIF-2alpha;Elements;Enabling Factors;endoplasmic reticulum stress;Genetic;hallmarks of aging;Heme;Human;Huntington Disease;In Vitro;Induction of Apoptosis;inhibitor;insight;kinase inhibitor;Length;Link;Mediating;Mediator;Methodology;Mitochondria;Mitochondrial Proteins;Molecular;molecular marker;monomer;Mutagenesis;N-terminal;Neurons;novel;Parkinson Disease;particle;Pathologic;Pathology;Pathway interactions;Phosphorylation;Phosphotransferases;Physiological;PRKR gene;Production;Protein Kinase;Proteins;proteostasis;proteostasis loss;Recombinants;recruit;Resolution;response;Role;scaffold;sensor;Signal Transduction;Signaling Molecule;Stress;Stress Response Signaling;Structure;targeted treatment;Testing;Therapeutic Intervention;transcription factor;Translations;Virus Diseases;Work

PROJECT_TITLE: Structure-function studies of DELE1-mediated activation of the integrated stress response

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Aging;Biotechnology;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative In mammals, while DNA methylation levels at specific CpG sites correlate with age and have led to the development of epigenetic aging clocks, the causal relationship between methylation and aging-related phenotypes remains unclear. This proposal aims to refine these clocks by incorporating causality, using Mendelian Randomization to identify causal CpGs, and further harnessing protein language models in the K00 phase to understand and design proteins linked to longevity. The outcome could revolutionize aging research by distinguishing age-related damage from adaptation, leading to precise aging biomarkers and a new approach to treat aging through proteome redesign.

PI_NAMEs: YING, KEJUN  (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Address;Age;age acceleration;age related;age related changes;Aging;aging biomarker;aging clocks;aging mechanism;aging population;aging process;aging related;anti aging;biological age;Biological Markers;Blood;Categories;Chronic;clinical application;Communities;Complex;Data;Databases;design;Development;DNA Methylation;DNA Structure;Elderly;Engineering;Epigenetic age;epigenetic aging;epigenetic clock;epigenome;Etiology;Evolution;Exhibits;Foundations;functional outcomes;Gene Expression;Generations;generative models;Genomics;Health;Human;improved;in silico;In Vitro;insight;Intervention;Knowledge;Language;large language model;life span;link protein;Longevity;Machine Learning;machine learning model;Mammals;Measures;Mendelian randomization;Metadata;Methods;Methylation;model design;Modeling;Molecular;Mus;novel;novel strategies;Organism;Outcome;Phase;Phenotype;Postdoctoral Fellow;practical application;pro-aging;Process;protective effect;Protein Engineering;protein structure;Proteins;Proteome;Research;Research Personnel;Research Project Grants;Resources;Sampling;screening;Site;small molecule;Standardization;Structure;System;Testing;Tissues;tool;trait;Variant;Work

PROJECT_TITLE: Using causal aging biomarkers and protein design to develop novel anti-aging interventions

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-J (M1)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

PHR: Project Narrative Spatially-resolved single-cell sequencing data have the potential to explain how cells communicate and interact, how cell state is impacted by its local environment, how specific dysregulation might eventually lead to disease, and how targeted interventions might modify cell state to treat disease. Our goal in this proposal is to develop spatial statistical methods to ensure that this potential is achieved; in particular, our proposed methods will i) create robust software to build multiscale, three-dimensional, queryable, cell-type aware, and reference- free atlases of tissues and organs from a handful of two-dimensional spatial genomics samples, ii) annotate these atlases by finding spatially-resolved expression patterns within and across cell types, and iii) quantify the influence of each aligned cell in the atlas on their local environment. In this proposal, we are motivated by existing data from mouse and human heart, mouse and human brain, and human brain tumors, where both common and rare cell types, expression gradients critical to tissue function, and essential cell-cell interactions are just beginning to be discovered and understood.

PI_NAMEs: ENGELHARDT, BARBARA  (contact)

PROGRAM_OFFICER_NAME: SEN, SHURJO KUMAR

PROJECT_TERMS: 3-Dimensional;Address;Adult;analytical method;Atlases;Awareness;Biological;Biological Assay;Brain;Brain Neoplasms;Budgets;Catalogs;Cell Communication;cell type;Cells;Cellular biology;Complex;Computer software;Computing Methodologies;Data;data modalities;design;Development;differential expression;Disease;Disparate;Dissociation;diverse data;Environment;Experimental Designs;flexibility;Gene Expression;genomic biomarker;genomic data;Genomics;Glioblastoma;Goals;graphical user interface;Heart;Histology;Human;human disease;Image;imaging Segmentation;In Situ;Individual;insight;interest;Intervention;Manuals;Maps;Measures;Methods;Modeling;multi-scale atlas;multimodal data;Mus;Neighborhoods;Organ;Organism;Pattern;Process;Proteomics;reconstruction;Research Personnel;Resolution;Resources;Sampling;scaffold;single cell ATAC-seq;single cell sequencing;single-cell RNA sequencing;Slice;Slide;Solid;spatial integration;Specificity;Statistical Methods;Statistical Models;Structure;System;Technology;Tissue atlas;Tissues;tool;transcriptomics;tumor;two-dimensional;user-friendly;Validation;Variant;Visualization;Walking

PROJECT_TITLE: Methods to build and annotate tissue atlases using spatial genomic data

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: SEATTLE

ORG_NAME: BENAROYA RESEARCH INST AT VIRGINIA MASON

ORG_STATE: WA

PHR: PROJECT NARRATIVE  Systemic lupus erythematosus is a complex autoimmune disease characterized by the presence of circulating autoantibodies to nucleic acids and proteins with which they associate. These antibodies form immune complexes that then activate white blood cells, including plasmacytoid dendritic cells that are important in lupus disease. In this proposal, we investigate how different autoantibody types contribute to immune complexes, activation of plasmacytoid dendritic cells, and lupus disease.

PI_NAMEs: HAMERMAN, JESSICA A (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Affect;Antibodies;Antigen-Antibody Complex;Antigens;Antinuclear Antibodies;Asian ancestry;Asian population;Autoantibodies;Autoantigens;Autoimmune Diseases;Autologous;Automobile Driving;B-Lymphocytes;Binding;Biological;Black Populations;Black race;Brain;Cardiovascular system;Cells;cohort;Complex;cytokine;Cytoplasmic Tail;Dendritic Cells;Diagnosis;Disease;DNA;ds-DNA;Endosomes;Family member;Fc Receptor;Genomic DNA;Hispanic ancestry;Histone H1;Histone H2A;Histone H2B;Histones;Human;IgA1;Immune;Immunoglobulin A;Immunoglobulin G;In Vitro;in vivo;Individual;Inflammatory Response;innovation;Interferon alpha;Interferons;ITAM;Joints;Kidney;Leukocytes;Lung;Lupus;Lupus Nephritis;Mediator;Multivesicular Body;novel;Nuclear Antigens;Nucleic Acids;Nucleosomes;Organ;Pathogenesis;Pathology;Pathway interactions;Patients;POLB gene;Production;Proteins;Race;Research;Research Institute;response;Ribonucleoproteins;RNA;Role;Sampling;Serum;Severities;Signal Transduction;Single-Stranded DNA;Skin;Structure;synergism;System;Systemic Lupus Erythematosus;Testing;therapeutic target;TLR7 gene;tool;U1 Small Nuclear Ribonucleoprotein;Variant;Woman

PROJECT_TITLE: Plasmacytoid dendritic cells and IgA autoantibodies in SLE

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: SYRACUSE

ORG_NAME: SYRACUSE VA  MEDICAL CENTER

ORG_STATE: NY

PHR: Many Veterans experience impairing symptoms of anxiety and seek treatment in the primary care setting, yet behavioral (non-medication) anxiety treatment options in primary care are quite limited. Primary Care-Mental Health Integration (PCMHI), in which mental health clinicians embedded in primary care provide behavioral treatment, can help bridge this treatment gap, but brief anxiety interventions that are compatible with PCMHI practice are needed. This proposal evaluates a brief anxiety intervention that is evidence-based, transdiagnostic (applicable to a wide range of anxiety symptoms), feasible for delivery in PCMHI (brief sessions), and Veteran-centered (tailored to Veterans and personalized to individual patients). This research addresses a major gap in VHA treatment options for anxiety and will facilitate high quality Veteran healthcare that improves clinical outcomes and patient experience. The intervention’s innovative modular design, in which Veterans collaboratively select which coping skills to learn, improves treatment engagement and acceptability.

PI_NAMEs: SHEPARDSON, ROBYN LEANNE (contact)

PROJECT_TERMS: Address;Adult;Anxiety;Anxiety Disorders;anxiety reduction;anxiety symptoms;anxiety treatment;Area;associated symptom;Behavior Therapy;Behavioral;behavioral health;brief intervention;care providers;care systems;Caring;Client satisfaction;Clinical;clinically significant;Cognitive;Cognitive Therapy;comorbidity;Consultations;coping;Coping Skills;Data;Depressed mood;depressive symptoms;design;Development;Diagnosis;Diagnostic;diagnostic strategy;Early treatment;Educational Intervention;Effectiveness;effectiveness evaluation;effectiveness-implementation RCT;Ensure;evidence base;Evidence based intervention;experience;Face;flexibility;follow-up;Funding;future implementation;Health Personnel;Health Services Accessibility;Health Services Research;Healthcare;High Prevalence;Hybrids;Impairment;implementation efforts;implementation science;improved;individual patient;innovation;Intervention;intervention delivery;Leadership;Learning;Logistic Regressions;Maintenance;Manuals;Measures;medical specialties;Mental Health;Mental Health Services;Methodology;Methods;Modeling;multilevel analysis;Nonpharmacologic Therapy;Outcome;Participant;Patient Preferences;Patients;Pharmacotherapy;Philosophy;preference;prevent;Primary Care;primary care patient;primary care setting;primary outcome;Procedures;process evaluation;Protocols documentation;Provider;psychoeducation;Psychotherapy;Quality of life;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;relapse prevention;Relaxation;Research;research and development;Research Methodology;routine care;satisfaction;secondary outcome;Severities;Site;skills;skills training;Sleeplessness;Stress;suicidal;Suicide prevention;Supervision;Symptoms;Techniques;therapy design;treatment as usual;Treatment Protocols;treatment response;trial comparing;United States Health Resources Administration;Use Effectiveness;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Improving Anxiety Treatment Engagement and Effectiveness in Primary Care-Mental Health Integration: Multi-site Hybrid I RCT of a Brief Veteran-Centered Anxiety Intervention

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Chronic Pain;Depression;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioids;Pain Research;Substance Misuse

ORG_CITY: BOCA RATON

ORG_DEPT: CHEMISTRY

ORG_NAME: FLORIDA ATLANTIC UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE Pain is a major global health problem, causing a significant economic and social burden. To address the need for novel therapeutics to treat acute and chronic pain, we designed new peptide- based analgesics suitable for intranasal administration that combine selective opioid and antidepressant pain-relieving mechanisms. These novel peptide-based dual-mechanism analgesics may exhibit improved efficacy in treating pain while reducing negative side effects associated with the traditional opioid pain medications.

PI_NAMEs: CUDIC, PREDRAG  (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: abuse liability;Acute Pain;addiction;Address;Adverse effects;Affinity;Agonist;American;Amino Acid Sequence;Analgesics;anti-depressive agents;Binding;Biological;Biological Assay;Blood;Blood - brain barrier anatomy;blood cerebrospinal fluid barrier;Blood specimen;Brain;brain tissue;Bypass;Central Nervous System;Chemistry;chronic neuropathic pain;chronic pain;Chronic pain syndrome;Clinical;collaborative environment;Continuity of Patient Care;Cyclic Peptides;Data;design;Development;Dose;dysphoria;Economics;Exhibits;experience;global health;Goals;High Pressure Liquid Chromatography;improved;In Vitro;Injury;Innovative Therapy;insight;Intranasal Administration;Intravenous;kappa opioid receptors;Knowledge;Lead;lead optimization;Ligands;Mediating;Metabolic;Metabolic Biotransformation;Methods;Modeling;multidisciplinary;Mus;Neurotransmitters;Norepinephrine;Nose;novel;novel therapeutics;Olfactory Nerve;Oligosaccharides;Operative Surgical Procedures;Opioid;Opioid agonist;Opioid Analgesics;Opioid Receptor;opioid use;Oral;Pain;pain inhibition;Pain management;pain model;pain relief;Parents;Patients;peptide analog;peptide drug;Peptides;Pharmaceutical Preparations;Physical Dependence;Physiological;Polypharmacy;pre-clinical;preclinical development;preclinical study;Property;receptor;Receptor Activation;Research;response;Rodent Model;Role;Route;Safety;scaffold;Series;Serotonin;side effect;social;Societies;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Students;Syndrome;System;Testing;Therapeutic;Therapeutic Agents;Tissue Sample;Training

PROJECT_TITLE: Novel Cyclic Peptide Analgesics for Intranasal delivery

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Human Fetal Tissue;Immunization;Infectious Diseases;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Vaccine Related;Women's Health Research

ORG_CITY: LONDON

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE

ORG_ZIPCODE: SW7 2AZ

PHR: Human Cytomegalovirus (HCMV) is the most common cause of congenital infection, leading to hearing loss and various developmental disabilities in affected newborns, with the potential for life-long consequences. Despite its substantial clinical and economic impact, our understanding of how HCMV crosses the placenta to infect the fetus remains incomplete, and the specific role of placental macrophages in managing or permitting HCMV transmission is especially obscure. This research will contribute fundamental knowledge about the mechanism and functional impact of HCMV infection in placental macrophages; vital in our efforts to develop preventative and therapeutic strategies against congenital HCMV.

PI_NAMEs: HOLDER, BETH  (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Affect;Antibodies;antibody test;antibody-dependent cell cytotoxicity;antibody-dependent cellular phagocytosis;Area;Binding;bioinformatics pipeline;Birth;carbohydrate binding protein;carbohydrate receptor;Cell Communication;Cell membrane;Cell Separation;cell type;Cell-Matrix Junction;Cells;Cellular Assay;Chorionic villi;Circulation;Clinical;Coculture Techniques;Communities;Complex;congenital infection;Cytomegalovirus;Cytomegalovirus Infections;Cytomegalovirus Vaccines;Data;Data Set;deafness;Decidua Basalis;Development;Developmental Disabilities;economic impact;experimental study;Fc Receptor;fetal;Fetus;Fibroblasts;First Pregnancy Trimester;Future;Generations;Glycoproteins;glycoproteomics;Goals;hearing impairment;Human;Human Biology;Humoral Immunities;Immune;Immune Evasion;Immunologist;improved;In Vitro;Infection;innovation;insight;interest;Intervention;Investigation;Knowledge;Label;Lectin;Life Cycle Stages;Macrophage;Mass Spectrum Analysis;Maternal antibody;maternal serum;Maternal-Fetal Exchange;Mediating;Mediator;Membrane Proteins;Methodology;Modification;Molecular;monocyte;Newborn Infant;novel;novel therapeutics;pathogen;Patients;Pharmaceutical Preparations;phase III trial;Phenotype;Placenta;Play;Polysaccharides;Pregnancy;prevent;Primary Infection;Process;Proteins;Proteome;Proteomics;Publishing;receptor;Research;response;Risk;Role;Running;Second Pregnancy Trimester;Sensorineural Hearing Loss;Serum;sex;Site;superinfection;System;targeted treatment;Techniques;Technology;Therapeutic;Therapeutic Intervention;therapeutic target;Time;transmission process;Vaccine Design;Vaccines;Viral;Virion;virology;Virus;Virus Diseases;virus host interaction

PROJECT_TITLE: The role of placental macrophages in cytomegalovirus infection at the maternal-fetal interface

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 HSC-X (M1)]


NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: Nashville

ORG_DEPT: BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE (Public Health Relevance) As the world's population ages, the search for cellular rejuvenation, a way to restore cells to a youthful state, offers hope for addressing age-related health challenges. This project aims to explore cellular rejuvenation mechanisms, emphasizing the rejuvenating potential of transcription factors in post-mitotic cells. The success of this work could lead to new and safer treatments, and the identification of universal rejuvenating factors with the potential to rejuvenate multiple tissues, setting a stage for translation into human therapy.

PI_NAMEs: HAN, DONGSHENG  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Address;Affect;Age;age related;aged;Aging;aging population;Binding;Biochemical;Biological;Biological Assay;Biology;Bromodomain;CDKN2A gene;cell age;Cell Aging;Cell division;cell injury;Cell model;Cells;Chromatin;Chromatin Remodeling Factor;Clinical;Co-Immunoprecipitations;Complex;Data;Defect;Development;Disease;DNA;DNA biosynthesis;DNA Damage;DNA Sequence Alteration;Down-Regulation;Drosophila genus;Epigenetic Process;experimental study;extend lifespan;EZH2 gene;Fibroblasts;fly;Fractionation;Gene Expression;Gene Expression Profile;Genome;Goals;hallmarks of aging;Health;helicase;histone modification;Human;Impairment;improved;In Vitro;in vivo;Induced Neurons;Intervention;Kinetics;Lysine;Maintenance;Malignant Neoplasms;Mediating;Methylation;Mitochondria;Mitotic;Modeling;Modification;Molecular;Molecular Biology;molecular phenotype;Mus;mutant;Neurons;novel;origin recognition complex;overexpression;Phase;Polycomb;Population;postmitotic;Process;Proteins;proteostasis;proteostasis loss;public health relevance;recruit;Regulation;Rejuvenation;Replication Initiation;Replication Origin;Research;Risk;senescence;Site;skills;success;System;Testing;Time;Tissues;Training;transcription factor;transcriptome;transcriptomics;Translations;tumorigenic;Ubiquitin;Ubiquitination;Work

PROJECT_TITLE: Unravel the Epigenetic Mechanisms of Cellular Rejuvenation and Identify Universal Rejuvenating Transcription Factors


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Individuals with Autism Spectrum Disorders (ASD) have significant difficulties with organization, planning, prioritizing, memory, and materials management which negatively impacts their educational performance (e.g., academic achievement, grades, etc.). Given that the lifetime cost for an individual with ASD is estimated to be $1.4 million per patient, with the largest of these costs for special education and parental productivity loss, there is a clear need for interventions that target increasing academic skills that lead to more successful outcomes. Developing psychosocial skills-based treatments that target academic success for students with ASD and their parent as they manage the increased demands of middle school may improve immediate academic and educational outcomes as well as buffer long-term impairment.

PI_NAMEs: DUNCAN, AMIE MARIE;TAMM, LEANNE  (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Academic achievement;Academic skills;Achievement;active comparator;Address;adolescent with autism spectrum disorder;Age;Agreement;Auditory;autism spectrum disorder;autistic;autistic children;Behavior;Behavioral;Buffers;Caregivers;Child;Clinical Trials;cohort;college;Communication;comorbidity;Control Groups;cost;design;Disabilities experience;Early treatment;Education;Educational Curriculum;Educational process of instructing;efficacy evaluation;efficacy testing;elementary school;Employment;evidence base;Evidence based intervention;Executive Dysfunction;executive function;expectation;falls;Family;Feedback;Focus Groups;follow-up;Funding;Future;Goals;group intervention;high school;Home environment;Impairment;improved;improved outcome;individuals with autism spectrum disorder;Instruction;Intellectual functioning disability;Intervention;junior high school;Learning;life time cost;Linguistics;Link;Maintenance;Mediating;Memory;Middle School Faculty;Modeling;multitask;National Institute of Child Health and Human Development;novel;Outcome;Outpatients;Parents;Participant;Patients;peer;Performance;pharmacologic;Population;post intervention;primary endpoint;Problem Solving;Process;productivity loss;psychosocial;Puberty;Public Health;Randomized;randomized, clinical trials;Reporting;Research Priority;Rewards;satisfaction;school environment;Schools;secondary endpoint;Self Determination;sex;skills;social;Special Education;Structure;Students;success;System;task analysis;teacher;Technology;Teenagers;therapy development;Time;Time Management;tool;trial comparing;Visual;Youth

PROJECT_TITLE: Achieving Independence and Mastery in Schools – An RCT for Middle-Schoolers with Autism

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Precision Medicine;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PI_NAMEs: REIS, STEVEN E (contact);VISWESWARAN, SHYAM

PROGRAM_OFFICER_NAME: MCNEIL FORD, NICOLE

PROJECT_TERMS: Acceleration;Adult;All of Us Research Program;Area;Biomedical Research;Black church;Black Populations;Black race;career;Caring;Child;Cities;Clinical Management;Clinical Sciences;cohort;Communication;Communities;community advisory board;community engaged research;community engagement;Community Health;community organizations;community partnership;Community Pharmacy;community research;Community Services;County;Data;Data Analytics;data exchange;Dedications;design;disability;Disabled Persons;Empathy;empowerment;Enrollment;Environment;Equity;ethnic diversity;ethnic minority;Evaluation;Event;experience;Faith;Fostering;Friends;Goals;health care availability;health care delivery;Health Personnel;Healthcare;Hispanic;hispanic community;Hospitals;Human;human centered design;Human Engineering;Immigrant;Independent Living;Individual;Informatics;Infrastructure;Institutional Review Boards;interest;Laboratory Research;Latino;Leadership;Learning;Lived experience;Location;Maps;marginalized population;Marketing;Media Campaign;meetings;member;Methods;Minority;Mission;Modeling;Multimedia;neighborhood disadvantage;Neighborhoods;operation;Outpatients;outreach;Parents;Participant;participant enrollment;participant retention;patient engagement;Pennsylvania;Pharmacists;Pharmacy facility;Philadelphia;physically handicapped;Population;Process;programs;Protocols documentation;prototype;racial diversity;racial minority;Ramp;Registries;Research;research and development;Research Ethics;Research Support;Research Training;Resources;Rural;rural area;Rural Community;Self-Help Devices;service organization;Services;Site;skills;Spinal;success;Time;Training;Training Activity;Translational Research;trustworthiness;United States;Universities;virtual;Work

PROJECT_TITLE: All of Us Pennsylvania (AOU PA) Research Program


ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Mental Illness;Prevention;Schizophrenia;Serious Mental Illness;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE The study goal is to promote viral load suppression among women with serious mental illness (SMI) and HIV in Botswana, given that these women are especially vulnerable to psychiatric medication nonadherence and symptom exacerbation, which are made worse by stigma and threaten antiretroviral therapy (ART) adherence. We propose to test an intervention to reduce stigma due to the statuses of SMI and HIV, against an attention control condition, in the high-risk transition period after discharge from an initial psychiatric hospitalization. Enabling women with SMI and HIV to resist stigma has the potential to improve their HIV outcomes and empower these women to elicit broader, structural-level change.

PI_NAMEs: YANG, LAWRENCE H (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: 2 arm randomized control trial;Acute;Address;Adherence;Africa South of the Sahara;Ambulatory Care;antiretroviral therapy;arm;Articulation;Attention;attentional control;Binding;Botswana;Caring;Client;Communities;community reintegration;compare effectiveness;coping;Depressive disorder;depressive symptoms;Educational workshop;empowerment;Ensure;Face;Family;Family Caregiver;Family member;follow-up;Foundations;Funding;Future;Goals;Health system;high risk;HIV;Household;improved;inpatient psychiatric treatment;Inpatients;Intervention;intervention effect;Lived experience;marginalization;marginalized population;Measures;medication nonadherence;Mental Health;Modeling;Mothers;novel;Outcome;peer;Perception;personalized approach;Personhood;Persons;Pharmaceutical Preparations;Placebo Control;Policies;Policy Maker;post intervention;Postpartum Period;Pregnant Women;Prevalence;primary outcome;Professional counselor;Public Health;Randomized;Randomized, Controlled Trials;reduce symptoms;Reporting;Research;Respondent;Risk;scale up;Schizophrenia;secondary outcome;Services;severe mental illness;Social outcome;social stigma;Symptoms;Testing;therapy adherence;therapy design;treatment adherence;Viral;Viral Load result;Woman;Women Status;women's outcomes

PROJECT_TITLE: RCT of an intersectional stigma intervention to sustain viral suppression among women living with serious mental illness and HIV in Botswana

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine;Rural Health

ORG_CITY: BIRMINGHAM

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PI_NAMEs: FOUAD, MONA N.;KORF, BRUCE R (contact);LEWIS, CORA E

PROJECT_TERMS: Agreement;Alabama;All of Us Research Program;Ancillary Study;Area;authority;Awareness;Bioethics Consultants;Biomedical Research;Cessation of life;Child;Childhood;Cities;Clinic;clinical center;Clinical Research;Clinical Sciences;Collaborations;Communication;Communities;community advisory board;Community Healthcare;Compensation;Computer Assisted;Computers;COVID-19;Dedications;Development;digital;Disabled Persons;Enrollment;Ensure;Event;Evolution;expectation;experience;Feedback;financial incentive;follow-up;Foundations;Funding;Genomic medicine;Geography;Goals;habituation;Health Personnel;Health Sciences;Health Services;impression;improved;Income;Individual;innovation;Inpatients;Institution;Internet;Lead;Learning;Letters;Location;Louisiana;Medical center;medical schools;meetings;member;Mississippi;Modeling;Monitor;Outcome;outreach;Participant;participant enrollment;participant retention;Pediatric Hospitals;Persons;Phase;Pilot Projects;Population;Positioning Attribute;Precision Health;precision medicine;precision nutrition;Productivity;programs;Protocols documentation;Questionnaires;Race;recruit;Resources;rural area;Rural Community;Site;Stretching;Structure;Students;success;Suggestion;Telephone Interviews;Time;Touch sensation;Translational Research;Trust;underserved community;Underserved Population;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: All of Us Southern Network v.2.0


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Biotechnology;Brain Disorders;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Xeroderma pigmentosum-Cockayne syndrome (XP-CS) is a rare, severe genetic syndrome that has characteristics of two classic DNA repair disorders that are usually clinically distinct: XP and CS. We have characterized a mouse model for one genetic subtype of XP-CS (XPG) and have designed a gene therapy vector to treat the severe neurodegeneration and extend lifespan in these mice. The goal of this project is to refine our gene therapy strategy to optimize efficacy and safety in preparation for translation of this approach into human clinical trials.

PI_NAMEs: PACAK, CHRISTINA A. (contact)

PROGRAM_OFFICER_NAME: CONRAD, CHRISTOPHER GARNER

PROJECT_TERMS: Acceleration;adeno-associated viral vector;Affect;Age;age acceleration;Alleles;Antibiotics;Ataxia;Biological Markers;Biological Models;biomarker evaluation;Brain;Capsid;cell type;Cells;cerebral atrophy;Cerebrum;Cessation of life;Characteristics;Clinical;Clinical Trials;clinically relevant;CMV promoter;Cockayne Syndrome;Codon Nucleotides;cohort;Complement;Complementary DNA;Cytomegalovirus;Dementia;Dependovirus;design;Development;Disease;DNA Damage;DNA Repair;DNA Repair Disorder;Dose;ERCC3 gene;Euthanasia;Evaluation;Excision Repair;experience;extend lifespan;Family;Future;gene therapy;Gene Transduction Agent;gene-targeted therapy;Generations;Genes;Genetic;Genetic Transcription;Goals;Histologic;Human;human induced pluripotent stem cells;human model;Impaired cognition;improved;induced pluripotent stem cell;Inherited;Knock-out;Knowledge;Life Expectancy;life span;Liver;Liver Failure;Metronidazole;Modeling;mouse model;Mus;Nerve Degeneration;Neurologic;Neurologic Symptoms;Neurological outcome;Neurons;Nuclear;Organoids;Other Genetics;Pathogenicity;Patients;Peripheral Nervous System Diseases;Phase;Phenotype;Pilot Projects;Preparation;promoter;protein expression;Proteins;Quality of life;Reaction;Review Literature;Route;Safety;Serotyping;Serum;Survival Rate;Syndrome;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;Tissues;Toxic effect;Translating;translational approach;translational barrier;Translations;treatment strategy;Tremor;uptake;Variant;vector;Xeroderma Pigmentosum

PROJECT_TITLE: Gene Therapy for Xeroderma Pigmentosum - Cockayne Syndrome.

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders B Study Section[NSD-B]


ADMINISTERING_IC: OH

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: BUTTE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: MONTANA TECHNOLOGICAL UNIVERSITY

ORG_STATE: MT

PHR: Relevance to Public Health The Montana Tech Safety, Health and Industrial Hygiene Department provides high quality, accessible, science and technology curricula and research opportunities designed to prepare students for successful OSH and IH careers. This is especially relevant to our public health because the burden of occupational injuries and illnesses in the U.S. has been estimated to be similar to the burden from cancer and exceed that of AIDS, Alzheimer’s disease, and arthritis.1 Despite the tremendous burden that occupational injuries and illnesses have on our society, fewer than half of the anticipated OSH professionals needed in the U.S. are anticipated to graduate in the coming years.2 We’ve been working hard to meet this demand since our first program was established in 1975 and we continue to grow and produce more qualified graduates thanks in large part to the support of the NIOSH TPG program.

PI_NAMEs: HART, JULIE F (contact)

PROGRAM_OFFICER_NAME: MAPLES, ELIZABETH

PROJECT_TITLE: Montana Tech Training Project Grant Application

STUDY_SECTION_NAME: Special Emphasis Panel[ZOH1 DVN (03)]


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Precision Medicine;Rural Health

ORG_CITY: TUCSON

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PI_NAMEs: MORENO, FRANCISCO A (contact);RADOVICK, SALLY ;REIMAN, ERIC MICHAEL;THEODOROU, ANDREAS A

PROGRAM_OFFICER_NAME: LOPEZ-CLASS, MARIA

PROJECT_TERMS: Academic Medical Centers;access disparities;Age;All of Us Research Program;Area;Arizona;Award;Awareness;Biomedical Research;Childhood;Colorado;Communities;community organizations;Data;Data Set;Electronic Health Record;Eligibility Determination;Enrollment;Ensure;Equity;experience;Family;Foundations;Funding;geographic disparity;Geography;Goals;Health;Health care facility;Health Personnel;Health system;Hispanic;improved;Individual;Information Technology;Infrastructure;innovation;Institution;interest;Knowledge;Latino;Leadership;Learning;literacy;Medical center;meetings;Methodology;Modeling;Nebraska;Nevada;New Mexico;New York;outreach;Participant;participant retention;patient engagement;Pediatrics;peer;Persons;Productivity;Program Accessibility;programs;prospective;Protocols documentation;Provider;recruit;Research;retention rate;rural area;Scientific Advances and Accomplishments;Services;Site;Spanish;success;Technical Expertise;Technology;United States National Institutes of Health;Universities;Utah;Wyoming

PROJECT_TITLE: University of Arizona-Banner Health Mountain Consortium


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: The outcomes of the proposed study will identify potential panels of miRNA biomarkers associated with early cognitive dysfunction, providing avenues for early disease detection through a simple and relatively unexpensive drop test. Moreover, the study will provide critical insights into molecular mechanisms that underlie AD development and progression. The findings will provide important foundational data to support an R01 study focused on identification of miRNA-related molecular mechanisms of AD and clinical trials to assess biomarker efficacy.

PI_NAMEs: KARERE, GENESIO  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: abeta deposition;Address;Affect;Age;Alzheimer's Disease;Alzheimer's disease diagnostic;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-42;Amyloid beta-Protein;Area Under Curve;Attention;attenuation;Biological Assay;Biological Markers;biomarker development;biomarker discovery;biomarker identification;Blood;Blood Tests;Brain;Brain region;brain tissue;Cardiovascular Diseases;Cerebrospinal Fluid;circulating microRNA;Clinical;clinical efficacy;Clinical Trials;Code;Cognition;Cognitive;Complex;cost;Data;Dementia;Deposition;Detection;Development;Diagnosis;diagnostic biomarker;diagnostic value;differential expression;Disease;Disease Progression;Drops;early detection biomarkers;early onset;Early treatment;Enrollment;Etiology;FDA approved;frontal lobe;Functional disorder;Future;Gene Expression;Gene Silencing;Genes;Goals;human old age (65+);human subject;Impaired cognition;Individual;ineffective therapies;insight;Intervention;Linear Models;Measurement;Mediator;Methods;microRNA biomarkers;MicroRNAs;mild cognitive impairment;Molecular;Molecular Profiling;Monitor;multiple omics;neuroimaging;new therapeutic target;novel;Outcome;Participant;Pathway interactions;Patients;Pattern;Peptides;Persons;Plasma;Positron-Emission Tomography;posttranscriptional;potential biomarker;pre-clinical;prevent;Process;Production;protein expression;Proteins;Receiver Operating Characteristics;Research;Risk;RNA Stability;Role;sample archive;Sampling;Sensitivity and Specificity;sex;Statistical Data Interpretation;tau Proteins;tau-1;Temporal Lobe;Testing;Therapeutic Agents;therapeutic target;Tissues;transcriptome sequencing;Translations;Universities;Untranslated RNA;Validation;Washington

PROJECT_TITLE: Potential miRNA biomarkers and miRNA regulatory targets underlying early congnitive impairement and progression to Alzhiemer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-W (02)]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Disability Research;Mental Health;Neurosciences;Rehabilitation;Stroke

ORG_DEPT: PSYCHOLOGY

PHR: Project Narrative The proposed research is relevant to public health because it capitalizes on intentional music listening to test the feasibility of a clinical trial aimed at improving mental health and wellness in chronic stroke. Findings will have direct, translational implications enabling clinicians to design large-scale clinical trials that allow for the optimization of music-based interventions for mental health recovery in stroke. Thus, the proposed research is relevant to the part of the NIH mission that pertains to reducing illness and disability.

PI_NAMEs: FUENTES, MAGDALENA ;RIPOLLES, PABLO  (contact);SCHAMBRA, HEIDI

PROGRAM_OFFICER_NAME: CHIDEYA-CHIHOTA, SEKAI RUTENDO

PROJECT_TERMS: Acoustics;Acute;acute stroke;Adherence;Affect;Age Years;aging related disease;Animal Model;Anxiety;Attention;Basic Science;Benchmarking;Brain;Brain Diseases;Brain Injuries;Cause of Death;Cessation of life;Chronic;chronic stroke;Clinical;Clinical Research;Clinical Trials;Clinical Trials Design;Cognitive;cognitive neuroscience;cognitive recovery;Data;Death Rate;design;disability;disability risk;Dose;Early treatment;Effectiveness;environmental enrichment for laboratory animals;experience;feasibility testing;feasibility trial;Feedback;Future;General Population;high risk;Impairment;improved;Incidence;Information Retrieval;Intervention;intervention refinement;Leisure Activities;Long term disability;Measures;member;Mental Depression;Mental disorders;Mental Health;Mission;Moods;mortality;mortality risk;Motor;motor impairment;motor recovery;motor rehabilitation;multidisciplinary;Music;Music Therapy;neuroimaging;Older Population;Outcome;Patients;Persons;post stroke;post stroke depression;programs;Property;Public Health;Randomized;Randomized, Controlled Trials;Recommendation;Recovery;recruit;remote delivery;Research;Research Personnel;Route;Sample Size;Sampling;Sensory;side effect;Social Environment;Standardization;Stroke;stroke patient;stroke recovery;stroke rehabilitation;stroke survivor;success;Survivors;Testing;Time;United States;United States National Institutes of Health;Upper Extremity;Veins;Well in self

PROJECT_TITLE: Feasibility of a music listening intervention for mental health recovery in chronic stroke

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 MH (09)]


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Disability Research;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Neurosciences;Pain Research;Primary Health Care;Social Determinants of Health

ORG_NAME: NORTHERN CALIFORNIA INSTITUTE/RES/EDU

PHR: The overarching goal of the wHOPE (Whole Health Options for Pain Education) study is to test the VA Whole Health model for chronic pain care in VA. Across six geographically distinct VA healthcare systems, we will test a Whole Health Team approach that includes an integrative medicine provider, a complementary integrative health provider (e.g., acupuncturist), and a Whole Health coach who collaborate with patients to identify a multi-modal non-drug approach for chronic pain management. The comparator will be more traditional Primary Care Group Education (modified group Cognitive Behavioral Therapy for Chronic Pain), and both will be compared to Usual Primary Care for pain care in VA. The enrollment target is 765 veterans, and the primary outcome is pain interference. An implementation evaluation and budget impact analysis will be conducted.

PI_NAMEs: BECKER, WILLIAM C;SEAL, KAREN H (contact)

PROGRAM_OFFICER_NAME: MURRAY, PETER DANIEL

PROJECT_TERMS: Address;Administrative Supplement;adverse outcome;Analgesics;Benzodiazepines;budget impact;Caring;chronic pain;chronic pain management;chronic pain patient;Clinical;Cognitive Therapy;cohort;Collaborations;collaboratory;comparison control;comparison intervention;cost;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;Development;Disability outcome;disability risk;Economics;Education;effectiveness/implementation trial;eligible participant;Enrollment;ethnic minority;evidence base;experience;Funding;Geography;Goals;health care delivery;Health Personnel;health plan;Healthcare;Healthcare Systems;high risk;Housing;Human Resources;human subject;Hybrids;implementation evaluation;improved;Infrastructure;instructor;Integrative Medicine;Intervention;Intervention Studies;Job loss;male;Masks;Medical;Mental Health;military service;Mission;Modeling;multimodality;non-drug;Nonpharmacologic Therapy;Nutritionist;Opioid;Pain;Pain intensity;Pain interference;Pain management;pain reduction;pain symptom;pandemic disease;Paper;Participant;participant enrollment;Patient Outcomes Assessments;Patient Recruitments;Patients;Persons;Pharmaceutical Preparations;Phase;Population Sizes;pragmatic trial;prescription opioid;Primary Care;primary outcome;Process;process evaluation;Protocols documentation;Provider;Psyche structure;Publishing;Quality of life;racial minority;Reporting;Research;Rural;Sample Size;Sampling;secondary outcome;Services;Severities;Sick Leave;Site;Sleep Disorders;Social Impacts;Subgroup;suicidal;Symptoms;System;Telephone;Testing;three-arm study;Time;Training;Trauma;United States National Institutes of Health;urban dwelling;Veterans;virtual delivery;War;whole health;Woman;Yoga

PROJECT_TITLE: Implementation of a Pragmatic Trial of Whole Health Team vs. Primary Care Group Education to Promote Non-Pharmacological Strategies to Improve Pain, Function and Quality of Life in Veterans


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Aging;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

PHR: Aging demonstrates striking individual diversity, as evidenced by the differing health paths and results observed among individuals of the same chronological age and is often influenced by environmental factors. In the F99 phase, I explore the interplay between environmental adversity and epigenetic changes during aging using a canine cohort. While the K00 phase expands on the previous research to focus on gender-specific environmental determinants of aging in women, drawing from diverse human cohort studies to identify high-risk groups and develop targeted interventions for enhancing healthy aging.

PI_NAMEs: MCCOY, BRIANAH  (contact)

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: Address;Affect;Age;age acceleration;Age disparity;age related;age related biomarkers;age related changes;age-related disease;Aging;aging population;aging process;Animal Model;Animals;Autoimmune Diseases;Automobile Driving;Bioinformatics;Biological;Biological Markers;Biology of Aging;Canis familiaris;Cardiovascular Diseases;Cessation of life;Chronology;Clinical;cohort;Cohort Studies;companion animal;Cues;Data;Development;Diabetes Mellitus;Diagnosis;Disease;Disease Marker;disorder risk;diverse data;DNA Methylation;drivers of aging;effective intervention;Environment;Environmental Exposure;Environmental Impact;Environmental Monitoring;Environmental Risk Factor;epigenetic clock;Epigenetic Process;epigenome;epigenomics;Equity;Ethnic Origin;Exclusion;Exhibits;experience;Face;Fellowship;Gender;Genes;Genetic;Genomics;Geroscience;Goals;Health;health care availability;health care disparity;healthspan;healthy aging;Heterogeneity;high risk population;Human;Immune system;Impairment;Individual;individual variation;insight;Interdisciplinary Study;Intervention;Knowledge;late life;life span;Link;Lived experience;Longevity;Longitudinal cohort;Longitudinal cohort study;Medical;men;Menopause;Minor;model organism;Molecular;Molecular Biology;mortality;novel;Onset of illness;Outcome;Perimenopause;Personal Satisfaction;personalized health care;Persons;Phase;Play;Population;Populations at Risk;Positioning Attribute;Postdoctoral Fellow;Pre-Eclampsia;Predisposition;Prevalence;Prevention;Process;psychologic;Race;Reproductive Health;Research;Research Project Grants;Risk;Role;Route;sex;Sex Differences;Shapes;Site;social;Social support;Study of Women's Health Across the Nation;Surveys;Techniques;Testing;Training;United States;Variant;Weight;Woman;Women's Group;Women's Health;Work

PROJECT_TITLE: Effects of environmental adversity on molecular aging in the immune system of companion dogs


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics

ORG_CITY: WACO

ORG_NAME: BAYLOR UNIVERSITY

ORG_STATE: TX

PHR: Project Narrative – To ensure genomic integrity, it is essential that DNA synthesis is efficient and error-free, and that DNA damage is bypassed quickly to maintain an active replisome. Therefore, cells have evolved several translesion DNA polymerases to respond to different lesions with limited processivity. Substitution of a high-fidelity polymerase for a translesion polymerase are multidimensional and rely on specific contacts for the initial recruitment, insertion, and extension processes; however, the molecular mechanisms for these events are unknown.

PI_NAMEs: TRAKSELIS, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: 8-hydroxyguanosine;Active Sites;Affinity;Aging;Archaea;Back;Bacteria;Biochemical;Biochemistry;Biological Models;biomedical scientist;Bypass;C-terminal;cancer initiation;Cells;Chemoresistance;Complex;Data;Dependence;design;Dimensions;Disease;Dissociation;DNA;DNA Binding;DNA biosynthesis;DNA Damage;DNA-Directed DNA Polymerase;Ensure;Enzymatic Biochemistry;Enzymes;Event;experimental study;Family;Fingers;Genetic;genome integrity;Genomics;Goals;graduate student;Health Sciences;Holoenzymes;Human;human DNA;Influentials;insight;Kinetics;Length;Lesion;Malignant Neoplasms;Measures;Mediating;Mentors;Modeling;Molecular;mutant;Mutation;next generation;novel;Patients;Polymerase;Positioning Attribute;prevent;Process;programs;protein purification;Proteins;recruit;Regulation;Research;Research Personnel;response;restraint;Specificity;structural biology;Structure-Activity Relationship;Students;Supervision;System;targeted treatment;Testing;therapeutic target;TNFRSF5 gene;tool;Training;training opportunity;undergraduate student;Universities;Work;X-Ray Crystallography

PROJECT_TITLE: Molecular control of translesion synthesis fidelity beyond the lesion


ORG_NAME: PACIFIC NORTHWEST RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Public health relevance: Approximately 50% of the human genome is constituted by repeats some of which contribute to genomic instability and DNA variation. This project will uncover the role of repeats to the formation of copy-number variants spanning dosage sensitive genes and their impact to gene regulation and disease.

PI_NAMEs: FONSECA, CLAUDIA CARVALHO (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Affect;Alleles;Architecture;Biological;Biological Process;Childhood;Cicatrix;Clinical;cohort;Complex;Congenital Abnormality;Copy Number Polymorphism;Data;Diagnosis;Disease;DNA biosynthesis;DNA Repair;DNA Sequence Rearrangement;dosage;Elements;Event;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Generations;Genes;Genetic;Genetic Diseases;Genetic Predisposition to Disease;Genetic Recombination;genetic variant;Genome;Genome Mappings;Genomic DNA;Genomic Instability;genomic locus;genomic predictors;Genomic Segment;Genomics;Genotype;Germ Lines;Haplotypes;homologous recombination;Human;human disease;Human Genome;Individual;insight;interest;Knowledge;Malignant Neoplasms;Maps;Mediating;Meiosis;Methodology;Modeling;Molecular;Mutation;nanopore;Nature;neurodevelopment;Neurodevelopmental Disorder;novel;Ontology;Optics;Pathogenicity;Phase;Phenotype;phenotypic data;Population;Predisposition;proband;Process;Property;public health relevance;Publishing;Rare Diseases;Recurrence;repaired;Role;Sampling;Sequence Deletion;Severity of illness;Structure;Syndrome;Testing;trait;transcriptome;transcriptome sequencing;transcriptomics;Variant;Work;Yeasts

PROJECT_TITLE: Investigating the Function of Highly Similar Intrachromosomal Repeats to Genomic Instability and Perturbed Gene Expression in Genetic Disorder

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Services;Precision Medicine;Social Determinants of Health

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: The AoURP at Mount Sinai contributes data from participants to a dataset that researchers could use to advance precision medicine, study diseases, and determine effective treatments. In the long term, data and insights from the AoURP may be used to determine new approaches for preventing disease.

PI_NAMEs: AZAN, ALEXANDER ;GELB, BRUCE D;HOROWITZ, CAROL R;JAY, MELANIE ;KAUSHAL, RAINU ;KRAFT, MONICA  (contact);NADKARNI, GIRISH NITIN;ROSS, MARGARET ELIZABETH;SHROFF, NANDINI ;SHUMAN, SASKIA ;TRINH-SHEVRIN, CHAU ;TROUSDALE, RHONDA

PROJECT_TERMS: Academic Medical Centers;Adult;Advocate;All of Us Research Program;Area;Arizona;Asian population;biobank;Biomedical Research;Child;Childhood;Cities;Clinical;clinical infrastructure;Clinical Trials Network;Collaborations;Communities;community collaboration;community consultation;community engagement;Community Health Aides;Community Networks;community organizations;Country;COVID-19;dashboard;Data Set;data tools;Databases;Enrollment;Ensure;Equity;ethnic minority population;experience;Family health status;Federally Qualified Health Center;Funding;Genomics;Geography;Goals;Grant;Health;health care delivery;Health equity research;Health system;Healthcare;Hospitals;improved;Infrastructure;Inpatients;insight;Institution;interest;Lead;Learning;Link;Marketing;Medicine;meetings;metropolitan;Municipalities;Neighborhoods;New York;New York City;non-genomic;Outpatients;outreach;Participant;Patient Recruitments;Patient-Focused Outcomes;Patients;Population Heterogeneity;programs;Provider;Qualifying;racial minority population;Recording of previous events;Recovery;recruit;Research;Research Institute;Research Personnel;Researching COVID to Enhance Recovery;retention rate;Services;Site;success;System;Training Programs;Trust;Underrepresented Populations;United States;United States Health Resources and Services Administration;United States National Institutes of Health;Universities

PROJECT_TITLE: All of Us Research Program New York Consortium


ORG_CITY: BOSTON

ORG_NAME: JOSLIN DIABETES CENTER

PHR: Project Narrative This project provides fundamental insights into how insulin regulates aging-associated genes. In addition, this project also sheds light on how aging shifts the cell response to insulin to promote metabolic diseases. Ultimately, this project has the potential to provide new genes or DNA elements as targets to achieve tissue rejuvenation, and new therapies for aging-associated type 2 diabetes and insulin resistance.

PI_NAMEs: LIU, XIANGYU  (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: 3-Dimensional;Aging;aging related;aging related disease;Animals;Apoptosis;Binding;Caenorhabditis elegans;CCCTC-binding factor;Cell Aging;Cells;Chromatin;Chromatin Loop;Data;Data Analyses;Data Set;Distal;DNA;DNA Methylation;Elements;Endoplasmic Reticulum;endoplasmic reticulum stress;Enhancers;Epigenetic Process;Exhibits;Fasting;Fatty acid glycerol esters;feeding;FOXO1A gene;Frequencies;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Genome;Genomics;Glucagon;hallmarks of aging;Hepatic;Hepatocyte;Homeostasis;Hormones;in vivo;insight;Insulin;Insulin Resistance;insulin signaling;knock-down;life span;Link;Liver;Mediating;Membrane;Metabolic;Metabolic Control;Metabolic Diseases;Metabolic dysfunction;Metabolic stress;Metabolic syndrome;methylome;Modeling;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Obesity;old mice;Play;Process;programs;promoter;Proteins;Pump;Rejuvenation;response;Role;senescence;Stress;Structure;System;Tissue-Specific Gene Expression;Tissues;Training;transcription factor

PROJECT_TITLE: Insulin regulates aging-associated genes through chromatin topology


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE. Alzheimer's disease (AD) is the sixth leading cause of death in the United States, affecting almost 6 million people which is expected to more than double by mid-century. The neuropathologic hallmarks of AD including β-amyloid (Aβ) plaques and tau neurofibrillary tangles accumulate in the brain decades before symptom onset, and drive downstream neurodegeneration, cognitive impairment, and death. Identifying genetic drivers of early neuropathologic changes like conversion to Aβ positivity (Aβ+) may lead to novel therapeutic targets useful earlier in the disease cascade when treatment is most effective.

PI_NAMEs: KORAN, MARY ELLEN IRENE (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Abeta clearance;Affect;Age;age effect;Age of Onset;Age Years;Aging;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Area;Artificial Intelligence;Biological;biological sex;Biology;Brain;Candidate Disease Gene;career;career development;Cause of Death;Cessation of life;Clinical;clinical diagnosis;clinical heterogeneity;cohort;Complex;Data;data harmonization;Data Set;design;Disease;Endocytosis;Female;Future;Gene Expression Profiling;Genes;Genetic;genetic analysis;genetic architecture;Genetic study;genetic testing;genome wide association study;genome-wide;Genomic Imprinting;genomic locus;Genomics;Geriatrics;Goals;Heritability;Heterogeneity;human imaging;Image;imaging biomarker;imaging genetics;Impaired cognition;Individual;Inflammatory;innovation;insight;Intervention;large-scale imaging data;Ligands;Light;Link;Masks;Mentors;Methods;Modeling;Molecular;Nerve Degeneration;Neurobehavioral Manifestations;Neurobiology;neuroimaging;neuropathology;new therapeutic target;Non-linear Models;novel;Participant;Pathway interactions;personalized intervention;Persons;Phagocytosis;Phenotype;Physicians;Play;Positioning Attribute;Positron-Emission Tomography;Publishing;Radiology Specialty;Research;Research Proposals;Resources;response;Risk;risk variant;Role;Sample Size;Scientist;Senile Plaques;serial imaging;sex;sex as a biological variable;Sex Differences;skill acquisition;Symptoms;tau aggregation;Techniques;Tissues;tool;Training;trait;treatment strategy;Underrepresented Populations;United States;Variant;Woman;Work;X Chromosome;β-amyloid burden

PROJECT_TITLE: Genetic architecture of age of onset of amyloid positivity: Integrating imaging and genetic tools to identify novel drivers of disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-6 (M1)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Biotechnology;Estrogen;Genetics;Human Genome;Lung;Women's Health Research

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

PHR: Project Narrative The current proposal will investigate the interaction between sex, sex hormones, hormone receptors gene expression and genetic variants in the risk for severe asthma across the lifespan in men and women.

PI_NAMEs: ZEIN, JOE  (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: Address;admixture mapping;Adrenal Glands;Adult;Affect;African American population;airway inflammation;airway obstruction;Allergic inflammation;Androgens;Asthma;Attenuated;Binding;biobank;Biological;Biological Markers;Biological Process;Blood;boys;bronchial epithelium;Bronchoscopy;caucasian American;Cells;Classification;Clinical;clinical phenotype;clinically actionable;cohort;Coupled;Cytokine Receptors;Data;Databases;Dehydroepiandrosterone Sulfate;Development;Disease;Disproportionately impacts women;DNA;Elements;endophenotype;Enrollment;Epithelial Cells;ESR1 gene;Estradiol;Estrogen Receptor 2;Estrogens;Excision;Exhibits;Female;follow-up;Future;Gender;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;gene interaction;Gene Order;gene regulatory network;Genes;Genetic;Genetic Risk;genetic variant;Genetic Variation;Genome;genome sequencing;genome wide association study;genome-wide;Genomics;Germ Lines;girls;Goals;Gonadal Steroid Hormones;Hormonal;Hormone Receptor;Hormones;human interactome;IL13RA1 gene;IL17 gene;IL4R gene;IL5RA gene;Immune;Immune system;Inflammation;Inflammatory;Interferons;Intervention;Knowledge;life span;Lung Diseases;male;Maps;Measures;member;men;Micro Array Data;Midlife women;Mitochondria;Modality;molecular phenotype;Multiomic Data;multiple omics;National Heart, Lung, and Blood Institute;Not Hispanic or Latino;novel;Nuclear Receptors;Outcome;Participant;Pathogenesis;Pathogenicity;Pathway interactions;Perimenopause;Persons;Phenotype;Play;Population;precision medicine;Prevalence;Production;Progesterone;Progesterone Receptors;programs;protein protein interaction;Proteins;Puberty;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;receptor expression;Regulation;Research;Research Proposals;Risk;risk stratification;risk variant;Role;Same-sex;Serum;Severities;sex;Sex Differences;sexual dimorphism;Signal Transduction;Sputum;Steroid Receptors;Systems Biology;Testing;Testosterone;transcriptome sequencing;Variant;whole genome;Woman

PROJECT_TITLE: Gender and Asthma

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Precision Medicine;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: The All of Us Research Program is building a cohort of over a million individuals who consent for the use of their data and biospecimens for health-related research. The Coast-to-Coast (C2C) Consortium is composed of a set of healthcare provide organizations that help All of Us recruit, retain, and facilitate interactions with the populations cared by their health systems.

PI_NAMEs: BOROWSKY, ALEXANDER D;GOODMAN, MARC T;HIATT, ROBERT A;KIM, SUE ELIZABETH;MEEKER, DANIELLA ;MONTALVO-ORTIZ, JANITZA LIZ;OHNO-MACHADO, LUCILA  (contact);SILVA, AMARILYS ;SITAPATI, AMY MONTAGUE

PROGRAM_OFFICER_NAME: ALEXANDER-TROUPE, STEPHANIE MELANIA

PROJECT_TERMS: Absenteeism at work;All of Us Research Program;Area;Awareness;Biomedical Research;Blood Banks;California;Catchment Area;Childhood;Church;Clinic;clinical infrastructure;clinical research site;Collaborations;collaborative environment;Collection;Communication;Communities;Community Healthcare;community organizations;community partners;Complement;Computers;Connecticut;Consent;Contract Services;cost;cost estimate;Costs and Benefits;Country;Creativeness;Data;data dictionary;data exchange;data sharing;Decision Making;Disease;Doctor of Philosophy;Education;Electronic Health Record;Enrollment;Equilibrium;ethnic minority population;Ethnic Origin;Ethnic Population;Event;experience;Faith-based organization;Geography;Goals;Grant;Growth;Health;Health Insurance Portability and Accountability Act;Health Personnel;Health system;Healthcare;Hot Spot;implementation science;improved;Income;Information Technology;Infrastructure;innovation;Institution;Internet;Joints;Knowledge;Latinx;Leadership;Learning;lens;Life Cycle Stages;literacy;Location;Low income;male;Marketing;Measurement;Medical center;member;Mission;Modeling;Monitor;multidisciplinary;novel;Outcome;outreach;outreach program;Participant;patient outreach;Patient Schedules;Patients;pediatrician;Persons;Population;Population Heterogeneity;Poverty;Precision Health;precision medicine;precision nutrition;Process;programs;Provider;Puerto Rico;Qualifying;Race;racial minority population;racial population;recruit;Research;Research Institute;retention rate;Retrieval;Rhode Island;Rural;rural area;rural setting;safety net;Schedule;Site;skills;Socioeconomic Status;socioeconomics;Spanish;success;Support Groups;System;Training;Underserved Population;United States;United States National Institutes of Health;Universities;urban setting;volunteer;Vulnerable Populations;wireless fidelity;Work;Youth

PROJECT_TITLE: All of Us Coast-to-Coast Strong recrUitment, Retention, and Facilitation (C2C SURF)


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Major Depressive Disorder;Mental Health;Mental Illness;Physical Activity;Rehabilitation;Serious Mental Illness

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Asian Americans with depression disorder frequently complain having co-occurring somatic distress, and there is no effective treatment for this co-occurring condition. This randomized clinical study will examine the feasibility, acceptability, and safety of integrating the Stress Management and Resiliency Training (SMART) with Qigong/Tai Chi (QTC) to treat Asian Americans with co-occurring major depressive disorder and somatic distresses. The findings of this study will provide the preliminary evidence for a large and more definitive study.

PI_NAMEs: YEUNG, ALBERT S. (contact)

PROGRAM_OFFICER_NAME: MUDD, LANAY MARIE

PROJECT_TERMS: acceptability and feasibility;American;Asian Americans;Attention;Awareness;Behavior Therapy;bilingualism;Boston;Caring;China;Clinical Research;Cognition;Cognitive;Cognitive Therapy;Communities;Control Groups;Depressed mood;depressed patient;depressive symptoms;design;Development;Disease;Distress;Educational process of instructing;effective therapy;Effectiveness;efficacy trial;emotional symptom;Emotions;Enrollment;Esthesia;evidence base;experience;feasibility testing;Focus Groups;Future;Hamilton Rating Scale for Depression;innovation;Inpatients;Intervention;intervention delivery;Knowledge;Major Depressive Disorder;Manuals;Medical;Medical Care Costs;member;Mental Depression;Mental Health Services;Mind;Mind-Body Intervention;mind/body;Modeling;Movement;National Center for Complementary and Integrative Health;online delivery;Outcome;Outpatients;patient population;Patients;Pattern;Persons;Physical Exercise;pilot test;Population Heterogeneity;preference;Prevalence;primary care setting;programs;Protocols documentation;Psychiatric therapeutic procedure;Psychiatrist;psychoeducation;psychologic;Psychology;Qi Gong;Randomized;randomized trial;recruit;Relaxation;remote intervention;Research;response;Safety;satisfaction;sedentary;Serious Adverse Event;Shapes;skills;social stigma;Strategic Planning;stress management;stress resilience;Structure;Symptoms;Tai Ji;teacher;Therapeutic Uses;Thinking;Time;Training;treatment arm;whole health

PROJECT_TITLE: Development and Pilot Testing of a Combined SMART and Tai Chi Intervention for Asian Americans with Depression and Somatic Symptoms

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 BH (02)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Climate-Related Exposures and Conditions;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: ALBUQUERQUE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: The US population has been progressively aging, resulting in prolonged duration of environmental toxicant exposures and a potential for increased vulnerability to new environmental insults. Consequently, there is a growing population at risk for Alzheimer’s disease and related dementias. This project will examine the effect of various pollutants, including wildfire smoke, microplastics, and heavy metals, on neurological conditions and multi-omic pathways leading to neurodegenerative disease.

PI_NAMEs: BHASKAR, KIRAN ;CAMPEN, MATTHEW J (contact);GU, HAIWEI ;YIM, SUN HEE

PROGRAM_OFFICER_NAME: PETANCESKA, SUZANA

PROJECT_TERMS: Acceleration;Age;Age Months;Aging;aging brain;Air;Air Pollutants;Air Pollution;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloidosis;anthropogenesis;Aridity;Arizona;Autopsy;behavioral health;behavioral impairment;behavioral phenotyping;Betula Genus;Biochemical;Biology;Blood - brain barrier anatomy;blood-brain barrier crossing;Brain;brain health;Cadmium;Cardiovascular Diseases;climate change;Climatology;cohort;Collaborations;Copper;Country;Data;Dementia;design;Diet;Disparate;DNA;early life exposure;Environment;Environmental Exposure;environmental justice;Environmental Pollutants;environmental stressor;Epigenetic Process;Event;extreme heat;fine particles;Flow Cytometry;Food;hazard;Health;Heavy Metals;high dimensionality;high risk;Human;Human body;indigenous community;Knock-in Mouse;late life;Lead;Life;life span;lipidomics;Malignant Neoplasms;Manganese;Medicine;Meta-Analysis;metabolic profile;metabolome;metabolomics;Metals;Mining;Molecular;mouse model;multiple omics;nano;Nature;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;Neurologic;Neurological outcome;neuropathology;New Mexico;novel;Oral;Outcome;Ozone;Particulate Matter;Pathogenesis;Pathologic;Pathway interactions;Pattern;Phenotype;Plastics;pollutant;Population;Populations at Risk;pre-clinical;pre-clinical research;programs;Proteins;Proteomics;proteostasis;Regimen;Research;Resistance;respiratory;risk prediction;Smoke;Source;Sweden;Tauopathies;Texas;Toxic Environmental Substances;toxicant;Toxicant exposure;transcriptomics;Transition Elements;Uncertainty;Universities;University resources;Vascular Dementia;Water;Wildfire;wood smoke

PROJECT_TITLE: PRE3BAD: Preclinical Research on Emerging Environmental Exposures, Brain Aging, and Dementia

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-P (M3)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Precision Medicine

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative The proposed project will use personalized approaches to study how brain networks vary across younger and older adults with and without Alzheimer’s Disease. Individual-centered approaches will help elucidate sources of variability in brain networks that lead to different patterns of cognitive decline in healthy and pathological aging.

PI_NAMEs: PEREZ RIVERA, DIANA CAROLINA (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Academia;Adult;Affect;Age;age group;age related changes;Aging;aging process;Alzheimer's Disease;anatomic imaging;Anatomy;Architecture;Atrophic;Attention;Attenuated;Behavior;behavior prediction;Benchmarking;Biological Markers;biomarker development;Brain;Brain region;career;Cerebellum;Cerebral cortex;Characteristics;Clinical;Cognition;Cognitive;cognitive change;cognitive function;Communication;Data;Data Pooling;Data Set;Dedications;denoising;Development;Disease;Disease Progression;diversity and inclusion;endophenotype;Ensure;executive function;Exhibits;Fostering;Functional Magnetic Resonance Imaging;Future;Goals;healthy aging;Impaired cognition;improved;Individual;Individual Differences;inter-individual variation;Intervention;Knowledge;life span;Link;Maps;Measurement;Measures;Memory;Mentors;Methodology;Methods;Nature;Neurobehavioral Manifestations;Neurocognitive;Neurodegenerative Disorders;older adult;Older Population;Participant;Pathologic;pathological aging;Pattern;personalized approach;Persons;Play;Population;Postdoctoral Fellow;pre-doctoral;Property;Research;Research Personnel;Rest;Role;Sampling;scaffold;Science;segregation;Severities;Signal Transduction;skills;Source;Symptoms;System;Techniques;tool;Training;Variant;Work;young adult

PROJECT_TITLE: Precision Mapping of Functional Networks in Healthy and Pathological Aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-J (M1)]


NIH_SPENDING_CATS: Aging;Clinical Research;Health Services;Patient Safety

ORG_CITY: LOS ANGELES

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Millions of older adults rely on care from home health aides (HHAs) to safely age in place, but high turnover and severe workforce shortages among HHAs increasingly prevent older adults from obtaining the care they need. Given a substantial body of evidence showing greater participation in workplace decisions is a key driver of HHA job satisfaction and retention, this proposal uses a cross-sectional survey to examine the role of home care cooperatives – businesses designed to prioritize HHA workplace participation – in HHA turnover, job quality, and care quality, and also designs and pilot tests a scalable digital training product aimed at enhancing HHA workplace participation. The project will also provide critical training and mentorship for Geoffrey Gusoff, MD, MBA, MS, an early career investigator seeking to be a leader in long-term care workforce innovation.

PI_NAMEs: GUSOFF, GEOFFREY M (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Activities of Daily Living;Aging;aging in place;arm;Businesses;career;Caring;clinical care;cognitive interview;Communities;community partnership;Cross-Sectional Studies;Data;design;Development;digital;Effectiveness;Empirical Research;Entrepreneurship;Evaluation;Exclusion;experience;Family Physicians;Foundations;Funding;Geriatrics;Goals;Health;Health Priorities;Health Services Accessibility;Health Surveys;Healthcare;Home;Home Care Agencies;Home Care Services;Home Health Aides;Hour;implementation science;improved;Industry;innovation;insight;International;Intervention;Intervention Trial;Job Satisfaction;Knowledge;Long-Term Care;Measures;Mediating;Mentors;Mentorship;Modeling;Occupations;older adult;Outcome;Ownership;Patient Care Planning;patient home care;patient retention;Patient-Focused Outcomes;Patients;Pilot Projects;pilot test;Population;Postdoctoral Fellow;prevent;Psychometrics;Quality of Care;Regression Analysis;Reporting;Research;Research Personnel;Role;Scholars Program;Services;skills;Small Business Innovation Research Grant;Structure;Surveys;Testing;Time;tool;Training;Wages;Work;Workplace

PROJECT_TITLE: The Role of Home Care Cooperatives in Home Health Aide Turnover, Job Quality, and Care Quality

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Disability Research;Hearing Loss;Rehabilitation;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Millions of older adults have hearing loss and a concurrent chronic illness, yet how hearing loss impacts self- care practices for chronic illness, health communication and healthcare use is poorly understood. This proposal examines these associations among diverse populations. Findings are anticipated to inform the development of a clinical intervention to improve chronic illness care delivery, enable care engagement and improve health outcomes for the millions of adults aging with hearing loss and a chronic illness.

PI_NAMEs: WALLACE, LAURA GIAMBATTISTA (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Address;Adult;Age;age related chronic disease;age-related disease;Aging;Atherosclerosis Risk in Communities;Award;Behavior;burden of illness;care delivery;career;career development;Caring;Chronic Care;Chronic Disease;Clinical;Clinical Data;clinical development;Communication;Communication impairment;Communities;cost;Data;Data Collection;Data Set;Decision Making;design;Development;Diabetes Mellitus;disability;Discipline of Nursing;Discourse analysis;Disparity;doctoral student;Education;Emergency department visit;Enrollment;Environment;epidemiologic data;Epidemiology;Equipment and supply inventories;Ethics;experience;Fellowship;Foundations;Gender;Health;health application;health communication;Health Promotion;Healthcare;Hearing;hearing impairment;Heart failure;hospital readmission;Hospitalization;human old age (65+);improved;improved outcome;Income;Intervention;Interview;Knowledge;lens;Link;low health literacy;Maintenance;Medicare claim;Mentorship;Methodology;Methods;Monitor;National Institute on Aging;older adult;Outcome;Outpatients;patient-clinician communication;Patients;Perception;Persons;Pharmaceutical Preparations;Phase;Population;Population Heterogeneity;Postdoctoral Fellow;pre-doctoral;Presbycusis;Prevalence;prevent;Process;prospective;Provider;Public Health;Pure-Tone Audiometry;Race;Research;Research Personnel;Research Project Grants;Research Training;Resources;Role;Sampling;Science;Self Care;Severities;Severity of illness;Shapes;skills;social consciousness;social determinants;social health determinants;Social support;Structure;Surveys;Symptoms;therapy development;Training;trend;Work

PROJECT_TITLE: The Influence of Hearing Loss on Care Engagement and Health Outcomes


NIH_SPENDING_CATS: Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: SAINT LOUIS

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: Neuropathic pain, a debilitating chronic pain condition that affects millions of individuals is difficult to treat and drugs currently used have numerous side effects, high abuse liability and limited efficacy. Here, we will establish a multidisciplinary team with relevant experience in drug development, translational pain research, pain biology and clinical trials and create the required infrastructure for the development of novel non-opioid, GPR34 receptor antagonists for the treatment of neuropathic pain.

PI_NAMEs: ARNATT, CHRISTOPHER K;SALVEMINI, DANIELA  (contact);WALKER, JOHN K.

PROGRAM_OFFICER_NAME: BACHMAN, JULIA LYNN

PROJECT_TERMS: Absence of pain sensation;abuse liability;Address;Affect;Agonist;allodynia;Analgesics;analog;antagonist;anti-depressive agents;Anticonvulsants;antinociception;Automobile Driving;Behavioral;behavioral phenotyping;behavioral response;behavioral study;beta-arrestin;Binding;Biochemical;Biological;Biology;Cells;Central Nervous System;Chemicals;chronic painful condition;Clinical;Clinical Trials;Coupled;Cryoelectron Microscopy;Data;design;Development;Development Plans;Disease;Dose;drug candidate;drug development;efficacy testing;endogenous opioids;experience;Fertility;Future;Genes;Human;Hypersensitivity;improved;in silico;in vivo;Individual;Inflammatory Response;Infrastructure;infrastructure development;Injections;Intellectual Property;Ipsilateral;Knockout Mice;Lead;Ligands;Link;lysophosphatidylserine;Mediating;Metabolic;meter;Methods;Microglia;Mitogen-Activated Protein Kinases;Modeling;Molecular;Motor;mouse model;multidisciplinary;nerve injury;Nervous System Trauma;neuroinflammation;Neurotoxins;Nociception;non-opioid analgesic;novel;Opioid;Pain;Pain Research;painful neuropathy;Penetration;Permeability;Persistent pain;Persons;Pertussis Toxin;Pharmaceutical Preparations;Phenotype;Property;Proteins;Rattus;receptor;recruit;Reflex action;Reporting;response;Rewards;Rodent;Rodent Model;Role;scaffold;side effect;Signal Pathway;Signal Transduction;Site;Solubility;Spinal Cord;Spinal cord posterior horn;Structure;System;targeted treatment;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;Time;transcriptomics;Trauma;Traumatic Nerve Injury;virtual screening;Withdrawal

PROJECT_TITLE: Development of selective GPR34 antagonists for the treatment of neuropathic pain

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-S (20)]


NIH_SPENDING_CATS: Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cerebrovascular;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: DEARBORN

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF MICHIGAN AT DEARBORN

ORG_STATE: MI

PHR: Public Health Relevance Statement: The neurovascular unit changes fundamentally during brain injury, which leads to neuroinflammation and neurodegeneration. Studying chirality, polarization, and cell-cell interactions of the cells of the neurovascular unit could be critical for the development of novel therapeutic solutions for various brain disorders associated with blood-brain barrier disruption.

PI_NAMEs: ZHANG, ZHI  (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Achievement;Animal Model;Astrocytes;Biological;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier disruption;Brain;Brain Diseases;brain endothelial cell;Brain Injuries;Cardiac Myocytes;career;cell behavior;Cell Communication;Cell Shape;cell type;Cells;Central Nervous System;Cerebrovascular Circulation;Cerebrum;Chick;Data;Development;Embryonic Development;Endothelial Cells;Endothelium;Engineering;Extracellular Matrix;Female;First Generation College Students;Foundations;Goals;Heart;Homeostasis;Immune;Impairment;Inflammatory;Injury;injury and repair;innovation;Institution;Knowledge;Left;Maintenance;Microglia;migration;Morphogenesis;Nerve Degeneration;Nervous System Disorder;Neuroglia;neuroinflammation;Neurologic;Neurons;neuroprotection;neurotoxic;neurovascular unit;novel;novel therapeutics;Organ;Organelles;Outcome;Pathologic;Pericytes;Phenotype;Physiological;Play;Positioning Attribute;Process;Property;public health relevance;Regulation;Research;Role;Shapes;Smooth Muscle Myocytes;STEM student;Structure;Students;TBI treatment;Techniques;Therapeutic;Tissues;Translating;Traumatic Brain Injury;undergraduate student;university student;Work

PROJECT_TITLE: Understanding cell chirality and cell-cell interactions at neurovascular unit after brain injury

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Burden of Illness;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Palliative Care;Social Determinants of Health

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Public Health Relevance Statement  The purpose of this study is to develop and validate an inclusive Alzheimer’s disease and Alzheimer’s disease-related dementia (AD/ADRD)-focused measure of financial hardship for use by a diverse population of care contributors to persons living with dementia (PLWD). A validated screener that is inclusive enough to capture the unique experiences of PLWD —without distinction of race, religion, political belief, economic or social condition—and their care contributors in the context of AD/ADRD, will help with the early identification of those at greatest risk of financial hardship and related negative physical and mental health outcomes. The increasing prevalence of older adults with AD/ADRD, the growing diversity of the population, and projections that AD/ADRD is becoming the most expensive disease in the world suggest that this project has the potential to make a significant impact not only on the lives of PLWD and their care contributors but may also contribute vital knowledge to inform future programs and policies.

PI_NAMEs: BYBEE, SARA  (contact)

PROJECT_TERMS: abuse victim;Address;Adult;Advance Care Planning;adverse outcome;Advocacy;aged;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Caregiver Burden;Caring;cognitive interview;Communities;cost;Dementia;dementia care;Disease;Disparity;Early identification;Education;Elderly;Emotional;experience;Face;Factor Analysis;falls;Family;Family member;Feedback;Financial Hardship;Focus Groups;Future;gender minority;gender minority group;gender minority status;Goals;group intervention;Health;Health Care Costs;health disparity populations;health inequalities;health related quality of life;high risk;Impaired cognition;improved;Income;income disparities;Individual;Inequity;Institutionalization;Intervention;Intervention Studies;Knowledge;Legal;Lesbian Gay Bisexual Transgender;Lesbian Gay Bisexual Transgender Queer;marginalization;Measurement;Measures;Mental Health;Methods;older adult;Older Population;Outcome;Participant;peer;Persons;physical conditioning;Policies;Population;Population Heterogeneity;Prevalence;Primary Care;programs;Property;Psychometrics;Quality of life;Research;Research Design;Risk;Risk Factors;Sampling;Savings;screening;Services;Sexual and Gender Minorities;sexual minority;Shoulder;social;Social Network;Social support;stem;Structure;support network;Surveys;Testing;United States National Institutes of Health;Work

PROJECT_TITLE: Developing an Inclusive Measure of Financial Hardship for People Living with Dementia and their Care Contributors

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-5 (M1)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Nutrition;Obesity;Pancreatic Cancer;Prevention;Rare Diseases

ORG_DEPT: BIOCHEMISTRY

PHR: PROJECT NARRATIVE Obesity increases the risk for pancreatic cancer in patients, and high fat diet increases pancreatic cancer progression in mice. However, the mechanisms by which obesity and high fat diet increase pancreatic cancer remain unknown. This study will examine how diets enriched in specific fatty acids alter the pancreas to promote pancreatic cancer initiation and progression.

PI_NAMEs: CHRISTOFK, HEATHER  (contact);EIBL, GUIDO ERWIN MICHAEL;PLATH, KATHRIN

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Acceleration;Acinar Cell;Acute;Biological;Biology;cancer initiation;cancer risk;cancer therapy;Cancerous;cell type;Cellular Metabolic Process;Chromatin Structure;Coconut Oil;conditioning;Data;Development;Diagnostic;Diet;dietary;dietary control;Dietary Fats;Disease;Epidemiology;Epigenetic Process;Euthanasia;experience;Experimental Neoplasms;experimental study;Fatty acid glycerol esters;Fatty Acids;Gene Expression;Genetic Transcription;Health Promotion;Healthy Eating;High Fat Diet;Histologic;Histology;Human;in vivo;Incidence;Inflammation;Inflammatory;Injections;insight;interest;ketogenic diet;KRAS2 gene;KRASG12D;lard;Lesion;Link;Lipids;long chain fatty acid;Malignant neoplasm of pancreas;Malignant Neoplasms;Medium chain fatty acid;Metabolic;metabolic abnormality assessment;Metabolism;metabolomics;Methods;Modeling;Molecular;mouse model;Mus;neoplastic cell;Obesity;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pancreatic Intraepithelial Neoplasia;pancreatic neoplasm;pancreatic tumorigenesis;Pathogenesis;Patient risk;Patients;Persons;Phenotype;premalignant;prevent;Procedures;Recommendation;Risk;Role;Sampling;Saturated Fatty Acids;Serum;single cell ATAC-seq;single-cell RNA sequencing;Source;Survival Rate;Tamoxifen;Testing;Time;Tissues;transcriptomics;tumor;tumor growth;tumor initiation;tumor microenvironment;tumor progression;Tumor Promotion;tumorigenesis;tumorigenic;Work

PROJECT_TITLE: Impact of dietary lipids on pancreas cancer initiation and progression

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-F (M2)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Down Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Those with Down syndrome (DS) are at markedly increased risk for Alzheimer disease (AD); this disorder is referred to as DS-AD. Studies in animal models of DS-AD have provided important insights into pathogenesis and have phenocopied many DS-AD features. Importantly, as for DS-AD, increased APP gene dose is necessary for DS-AD-related phenotypes in models. Nevertheless, existing models fail to demonstrate the amyloid plaques, congophilic angiopathy and tau pathology of DS-AD. Given the importance of these lesions we propose to create them by genetically modifying the TcMAC21 model of DS through humanizing the Aβ sequence in mouse APP and introducing a wild type of human Tau transgene. We will seek internal validation in Aim 1 and external validation in Aim 2. Go/NoGo criteria for internal validation in Aim 1 and milestones for both Aims are defined. Our hypothesis is that genetically modified TcMAC21 mice will prove to be a fully valid of DS-AD to support studies of DS-AD pathogenesis and treatment.

PI_NAMEs: MOBLEY, WILLIAM C (contact)

PROGRAM_OFFICER_NAME: ROOF, REBECCA

PROJECT_TERMS: Acceleration;Age;age related;age related changes;Aging;aging population;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;Amyloid;Amyloid Beta A4 Precursor Protein;Amyloid beta-42;Amyloid beta-Protein;amyloid pathology;amyloid structure;Amyloidosis;Animal Model;Astrocytes;Biological Markers;Biological Models;C-terminal;Cause of Death;Cell Physiology;Cells;Cerebral Amyloid Angiopathy;Characteristics;Chromosomes;Clinical;clinical biomarkers;Clinical Trials;Cognition;Cognitive deficits;demented;Dependence;Diagnosis;Disease;disease phenotype;Disease Progression;Dose;Down's Syndrome;Elderly;Evaluation;Event;Face;Financial Hardship;Gene Dosage;Gene Modified;Genes;Genetic;genomic signature;Human;Human Chromosomes;human model;insight;Intervention;Lesion;Link;Measures;Microglia;model development;Modeling;Molecular;mouse model;Mus;Neurodegenerative Disorders;neurodegenerative phenotype;Neurofibrillary Tangles;neuroinflammation;neuron loss;Neurons;Pathogenesis;Pathologic;Pathology;Pattern;Peptides;Persons;Phase;Phenocopy;Phenotype;Population;prevent;protein aminoacid sequence;Proteins;Role;Senile Plaques;Synapses;tau expression;tau Proteins;tau-1;Testing;transcriptomics;Transgenes;Validation

PROJECT_TITLE: Develop and Validate a Mouse Model for Alzheimer Disease in Down Syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-M (19)]