ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Lung;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE As preterm infant survival continues to improve, uncertainty regarding the best treatment for hemodynamically significant patent ductus arteriosus (HSPDA) can have serious public health implications for this vulnerable population. A novel, US Food and Drug Administration approved duct occluder (ADO-II AS) now offers clinicians a minimally-invasive option for closing HSPDA, but its effectiveness in improving important patient outcomes, relative to supportive, noninterventional HSPDA management, is unknown. This project is relevant to NIH’s mission to understand the processes of human growth and development by determining via a multicenter randomized trial, whether percutaneous HSPDA closure using ADO-II AS improves cardiopulmonary and neurodevelopmental outcomes as compared to supportive, non-invasive therapy.

PI_NAMEs: KING, WENDY C;WISNIEWSKI, STEPHEN R (contact)

PROGRAM_OFFICER_NAME: BURNS, KRISTIN

PROJECT_TERMS: Adoption;Age;Arteries;artery occlusion;Belief;Birth;Brain;Brain Injuries;Cardiopulmonary;Cardiovascular system;Caregivers;Caring;Catheters;Cessation of life;Chronic lung disease;Circulation;Clinical;clinical research site;Communication;Complex;Consensus;Consent;Data;Data Coordinating Center;data management;data sharing;Devices;Diameter;Duct (organ) structure;Effectiveness;efficacy study;Ensure;Equipoise;Ethnic Origin;experience;Exposure to;extreme prematurity;Feasibility Studies;fetal;Gestational Age;Goals;Growth and Development function;Health Personnel;Heart;hemodynamics;Human;improved;improved outcome;in utero;Infant;Infant Health;International;Intervention;Left;Legal patent;Link;Lung;Measures;Mechanical ventilation;Mediating;Medical;Medication Management;minimally invasive;Mission;Monitor;Morbidity - disease rate;mortality;Neonatal;Neonatal Intensive Care;Neonatal Intensive Care Units;neonatal outcome;neurodevelopment;novel;Operative Surgical Procedures;Outcome;Output;Patent Ductus Arteriosus;Patient observation;Patient-Focused Outcomes;Patients;Peripheral;Pharmaceutical Preparations;postnatal;Pregnancy;Premature Infant;Preparation;prevent;Procedures;Process;protocol development;Protocols documentation;Public Health;Publications;Pulmonary artery structure;Pulmonary Hypertension;Race;Randomized;randomized trial;Randomized, Controlled Trials;recruit;Research Design;Respiratory Disease;Risk;Safety;secondary outcome;Severity of illness;sex;specific biomarkers;Statistical Data Interpretation;Techniques;Testing;Thoracic cavity structure;Training;trial comparing;Uncertainty;United States Food and Drug Administration;United States National Institutes of Health;Veins;Ventilator;Ventricular;Vulnerable Populations;Weight

PROJECT_TITLE: 2/2 Percutaneous Intervention Versus Observational Trial of Arterial ductus management in Low-weight infants (PIVOTAL) Data Coordinating Center


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Biotechnology;Brain Disorders;Cerebrovascular;Diabetes;Mental Health;Neurosciences;Rehabilitation;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DETROIT

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: HENRY FORD HEALTH SYSTEM

ORG_STATE: MI

PHR: Narrative: Diabetes mellitus accelerates cognitive decline in the growing aging population, and thus, development of specific therapeutic strategies to address DM induced cognitive impairment is of major clinical importance. Exosomes are naturally occurring nano extracellular vesicles that mediate intercellular communication by transferring their biomolecule content to recipient cells. Our preliminary data suggest that healthy cerebral endothelial cell-derived exosomes have potential for improving cognitive function in the aged DM rats. We therefore propose to develop a novel exosomes based therapy for DM-induced cognitive dysfunction.

PI_NAMEs: ZHANG, LI  (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Acceleration;Address;Adult;aged;Aging;aging population;angiogenesis;Bioinformatics;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier crossing;Brain;brain endothelial cell;Cells;Cerebral endothelium;cerebrovascular;Cerebrovascular Disorders;Cerebrum;Clinical;Cognitive deficits;cognitive function;Cognitive Therapy;Combined Modality Therapy;Communication;Couples;Data;Dementia;Development;Diabetes Mellitus;diabetes mellitus therapy;diabetic;diabetic rat;Elderly;endothelial dysfunction;endothelial stem cell;engineered exosomes;Exhibits;exosome;extracellular vesicles;Extravasation;Functional disorder;Funding;Genes;Harvest;Hippocampus;Human;Impaired cognition;Impairment;improved;Individual;innovation;intercellular communication;intravenous administration;Measures;Mediating;Metabolic Diseases;Microarray Analysis;MicroRNAs;middle age;Myelogenous;nano;nanosized;nerve stem cell;neurogenesis;Niacinamide;novel;Physiological;Play;Population;pre-clinical;Proteins;PTEN gene;Rattus;response;Rodent;Role;Streptozocin;Testing;Therapeutic;Therapeutic Effect;Thrombosis;Thrombospondin 1;Vascular Patency

PROJECT_TITLE: Cerebral endothelial cells derived exosomes as a therapy for cognitive impairment in aged diabetic rats

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: STANFORD

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: NARRATIVE Surgery is common in elders and appropriate postoperative pain management is critical, as poor management can impair recovery, lead to increased morbidity and decreased quality of life. The proposed research will develop evidence needed to identify elder patients at high risk for adverse postoperative pain outcomes. Models will be developed at a tertiary academic health center, validated at the Veterans Health Administration and disseminated to the community via a publicly available website and open source libraries.

PI_NAMEs: CURTIN, CATHERINE MILLS;HERNANDEZ-BOUSSARD, TINA  (contact)

PROGRAM_OFFICER_NAME: RODRICK, DAVID

PROJECT_TITLE: Identifying Optimal Pain Management for Elders

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Narrative: In this proposal, noninvasive imaging biomarkers of glutamatergic system changes in Alzheimer's disease (AD) pathology are developed and evaluated. Specifically, magnetic resonance imaging biomarkers of synapse loss and changes in astrocytic density will be evaluated longitudinally in mouse models that recapitulate the human AD. Results from this work will contribute to the mechanistic understanding of the AD onset and progression and lead to validated and clinically translatable biomarkers that can facilitate the development and evaluation of the efficacy of disease modifying therapies and thereby contribute to enhanced diagnosis and management of patients in the AD spectrum.

PI_NAMEs: REDDY, RAVINDER  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: abeta oligomer;Affect;Age;aging population;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease therapy;Amyloid beta-Protein;Animal Model;Animals;Astrocytes;Behavioral;Biological Markers;Brain;Brain region;brain volume;Cause of Death;cerebral atrophy;Characteristics;Chemicals;Clinical;clinical translation;cognitive change;cognitive skill;cohort;Data;Dementia;density;Detection;Development;Diagnosis;Disease;Disease Progression;early detection biomarkers;efficacy evaluation;Elderly;Etiology;excitotoxicity;Exhibits;extracellular;Gliosis;Glutamate Receptor;Glutamates;Hippocampus;Human;Image;imaging biomarker;imaging modality;Immunohistochemistry;Impairment;in vivo;indexing;Inositol;insight;Knock-in Mouse;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Magnetic Resonance Spectroscopy;Measures;Mediating;Memory impairment;Memory Loss;Methods;Molecular;mouse model;Mus;myoinositol;N-Methyl-D-Aspartate Receptors;Nerve Degeneration;Neurofibrillary Tangles;neuron loss;Neurons;neuropathology;neurotransmission;Neurotransmitters;non-invasive imaging;novel;Onset of illness;Patient Care;Patients;Persons;Play;Protein Isoforms;Reproducibility;Research;Resolution;Role;Senile Plaques;Signal Transduction;Specificity;Surrogate Markers;Synapses;Synaptic Transmission;System;tau Proteins;tau-1;therapy development;Translating;Wild Type Mouse;Work

PROJECT_TITLE: Imaging of glutamatergic system changes in Alzheimer's disease in vivo

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: LM

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention

ORG_CITY: ANN ARBOR

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Medical errors are the 3rd leading cause of death in the United States behind cancer and cardiovascular disease and the largest proportion of medical errors involve medications. These dispensing errors occur approximately 2,400,000 times every year in the United States alone and can result in patient safety issues and add unnecessarily to the already strained healthcare system.The objectives of this proposal are to: 1) design interpretable machine intelligence to double-check dispensed medication images in real-time; 2) evaluate changes in pharmacy staff trust due to the long-term use of interpretable machine intelligence; and 3) determine the effect of interpretable machine intelligence on long-term pharmacy staff work performance.

PI_NAMEs: AL KONTAR, RAED ;LESTER, COREY A (contact);YANG, X. JESSIE

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: Artificial Intelligence;Calibration;Cardiovascular Diseases;care costs;Cause of Death;Classification;Clinical;Cognitive;Communication;cost;Dangerousness;Data;Decision Making;deep learning;design;Detection;Development;Emergency department visit;Evaluation;experience;experimental study;Goals;Healthcare;Healthcare Systems;Hospitalization;Human;Image;improved;insight;Knowledge;Label;Legal;Life;Malignant Neoplasms;Measures;medical appointment;Medical Errors;Medication Errors;Methods;Modeling;Outpatients;Output;patient safety;Patient-Focused Outcomes;Patients;Performance at work;Persons;Pharmaceutical Preparations;Pharmacists;Pharmacy facility;prevent;Process;Provider;Research;sound;Stream;support tools;System;Testing;Thinking;Time;tool;Translating;Trust;Uncertainty;United States;Vial device;visual tracking;Work

PROJECT_TITLE: Preventing medication dispensing errors in pharmacy practice with interpretable machine intelligence

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Work in the proposed project could render a new mechanism of secondary injury for patients with traumatic brain injury. In the long term, the proposed experiments could lead to new therapies targeting receptor interacting protein kinase-3 function or its related pathways, and thereby improve quality of life of TBI survivors.

PI_NAMEs: WHALEN, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Acute;age related neurodegeneration;antagonist;Apoptosis;Astrocytes;Behavior;Bone Marrow;Brain;brain cell;brain endothelial cell;Brain Injuries;brain tissue;CASP8 gene;CD95 Antigens;Cell Death;Cell Fraction;cell type;Cells;Cerebral endothelium;Cessation of life;Chimera organism;Chronic;Chronic Phase;Clinical;Clinical Trials;Cognitive deficits;cognitive function;controlled cortical impact;Cortical Contusions;Data;Detergents;Disease;Down-Regulation;Endothelium;Etiology;Event;Experimental Models;experimental study;Fluorescence-Activated Cell Sorting;functional outcomes;Gaucher Disease;Gene Expression;Genetic;genetic regulatory protein;Goals;grasp;Hippocampus;Histology;HMGB1 gene;Human;Immune;immune cell infiltrate;Immunoprecipitation;improved;improved outcome;inducible Cre;Infiltration;Inflammasome;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;injured;Injury;Interleukin-1 beta;Knock-out;Knockout Mice;Lesion;Link;Macrophage;MAP Kinase Gene;MAP3K7 gene;Mediating;Methodology;Microglia;Modeling;Molecular;morris water maze;Motor;motor deficit;multicatalytic endopeptidase complex;Mus;Necrosis;Nerve Degeneration;Neurologic Dysfunctions;Neurological outcome;neuron loss;Neuronal Injury;Neurons;new therapeutic target;NF-kappa B;novel;object recognition;Outcome;p38 Mitogen Activated Protein Kinase;Pathway interactions;Peripheral;Phosphorylation;Phosphotransferases;Population;Protein Kinase Interaction;Protein-Serine-Threonine Kinases;Proteins;proteostasis;proteostasis loss;Publishing;Quality of life;Reagent;Receptor-Interacting Protein;Regulation;Reporting;Resolution;response;RIPK1 gene;RIPK3 gene;Role;Signal Transduction;stroke model;Survivors;Systemic disease;Tamoxifen;TBI Patients;TBK1 gene;Technology;Testing;therapeutic target;TLR4 gene;TNF gene;TNFRSF1A gene;tool;TRADD gene;Traumatic Brain Injury;Tumor Necrosis Factor Receptor;Ubiquitination;Up-Regulation;Western Blotting;Work

PROJECT_TITLE: Cell Specific RIPK3 Signaling After Traumatic Brain Injury in Mice

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Electronic Nicotine Delivery Systems;Infectious Diseases;Lung;Rare Diseases;Tobacco

ORG_CITY: NEW ORLEANS

ORG_DEPT: PATHOLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE Animal models are needed to better understand the mechanisms resulting in electronic vaping associated lung injury (EVALI). Components of the innate immune system play a major role in EVALI progression in humans. Nonhuman primates are ideally suited to investigate the innate immune mechanism underlying EVALI due to their similar anatomy and immunology to humans.

PI_NAMEs: BLAIR, ROBERT  (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: 2019-nCoV;Acceleration;Acute;Adolescent;Adolescent and Young Adult;Adoption;aerosolized;Aerosols;Affect;airway inflammation;Alveolar;Alveolar Macrophages;Anatomy;Animal Model;Area;Autopsy;Biological Assay;Bronchiolitis;Bronchoalveolar Lavage Fluid;career;career development;Cell Separation;Cells;Centers of Research Excellence;Cessation of life;Chad;chemokine;Clinical;comorbidity;cytokine;Data;Dedications;Defense Mechanisms;Defensins;Development Plans;Devices;Diffuse;Disease;disease model;Disease Outbreaks;Dyspnea;Educational workshop;electronic vape;Ensure;Environment;Enzyme-Linked Immunosorbent Assay;Exposure to;Flow Cytometry;Foundations;Functional disorder;Funding;Funding Agency;Future;Goals;Grant;HIV;Hospitalization;Human;Immune;immune cell infiltrate;Immunohistochemistry;Immunology;improved;Individual;Inflammation;Inflammatory;innate immune function;innate immune mechanisms;Innate Immune Response;Innate Immune System;interest;Investigation;Lipids;Liquid substance;Lower respiratory tract structure;Lung;Lung immune response;Macaca mulatta;Macrophage;Mentors;Mentorship;Microscopic;Modeling;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;National Institute of Drug Abuse;Nicotine;nonhuman primate;novel;Onset of illness;Pathogenesis;Pathogenicity;Pathologic;Patients;Phagocytes;Phagocytosis;Phenotype;Physiology;Play;Pneumonia;Policies;Positioning Attribute;Primates;Privatization;Public Health;pulmonary function;Pulmonary function tests;Pulmonary Inflammation;Pulmonary Pathology;radiological imaging;receptor expression;Reporting;Research;Research Personnel;Resources;Respiratory Disease;response;Rodent Model;Role;Saline;Sampling;SIV;skills;Study models;success;surfactant;System;targeted treatment;Terminal Bronchiole;Testing;Tetrahydrocannabinol;Time;Tissues;Toll-like receptors;Training;Trees;United States National Institutes of Health;Upper respiratory tract;vaping;vaping associated lung injury;Vitamin E Acetate;Writing

PROJECT_TITLE: The impact of vaping aerosol exposure on innate pulmonary defense mechanisms in nonhuman primates


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Machine Learning and Artificial Intelligence;Neurosciences

ORG_CITY: Nashville

ORG_DEPT: BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative The goal of the proposed research is to understand the principles that permit nervous systems to distinguish external from internally-generated sensory stimuli. Here I propose to develop a small circuit model of this process using the antennal mechanosensory system of the fruit fly. The insights gained from a tractable genetic circuit model will enable us to understand how these mechanisms fail in disease, supporting the BRAIN Initiative’s mission to understand the neural circuit basis of a critical brain function.

PI_NAMEs: SUVER, MARIE  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, KARI ANNE

PROJECT_TERMS: active control;Afferent Neurons;Animals;autism spectrum disorder;Behavior;Behavioral;Biological Models;Brain;BRAIN initiative;Cell model;Cells;Characteristics;Closure by clamp;Data;Disease;Drosophila genus;Drosophila melanogaster;Electrophysiology (science);Environmental Wind;Esthesia;expectation;experimental study;Failure;Fingers;fly;Flying body movement;Genetic;Genetic Models;goal oriented behavior;Goals;Grant;Hand;Human;Immunohistochemistry;Insecta;insight;Label;Learning;Location;Machine Learning;machine learning algorithm;Measures;Mechanoreceptors;Mediating;Mentors;Mission;model organism;Modeling;Molecular;Motor;Motor Neurons;Movement;Muscle;Nervous System;Nervous System Physiology;neural circuit;Neurons;Neurotransmitters;novel;Odors;optogenetics;Phase;Population;Postdoctoral Fellow;Process;Regulation;Research;Resolution;response;Role;Schizophrenia;sensor;Sensory;sensory integration;sensory stimulus;Shapes;Signal Transduction;Speed;Stains;Stimulus;Study models;System;Testing;tool;Touch sensation;Translating;Video Recording;Walking;Work

PROJECT_TITLE: Mechanisms of Active Sensing in Drosophila


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Visceral leishmaniasis (VL) is a neglected tropical disease which is fatal if left untreated. Majority of VL cases in the world are reported from Eastern Africa, particularly Ethiopia, Sudan, and Kenya. The goal of this project is to study the risk factors that are associated with transmission of this infection in these high endemic countries, understand the ecology and behavior of sand flies which transmit this disease and identify potential host and parasite factors responsible for disease progression and pathogenesis. These studies will provide critical data required for developing control and prevention strategies for elimination of VL from Eastern Africa.

PI_NAMEs: MATOKE, DAMARIS ;SATOSKAR, ABHAY R (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Address;Africa;Amphotericin;Animals;Asia;Automobile Driving;bacterial community;Behavior;Biology;Blood;bone;Bone Marrow;Breeding;Case Study;Cause of Death;Cells;Cessation of life;Chromosomes;Chronic;Classification;Clinical;Collaborations;Collection;Copy Number Polymorphism;Country;Data;density;Dermal;Development;Disease;disease phenotype;Disease Progression;disease transmission;Eastern Africa;Ecology;Epidemiology;epidemiology study;Ethiopia;feeding;Frequencies;Genes;Genetic;Genotype;global health;Goals;Gossypium;Growth;gut microbiota;healing;Human;Image;Immune;Infection;infection rate;innovation;Integration Host Factors;interdisciplinary approach;Intrinsic factor;Isoptera;Kenya;Knowledge;Left;Leishmania donovani;Leishmania infantum;Leishmaniasis;Lesion;Life;life span;Liposomes;Liver;Longevity;lymphadenopathy;macula;Malaria;Maps;Mutation;Nature;neglected tropical diseases;novel therapeutics;Organ;Outcome;parasite genome;Parasites;Parasitic Diseases;Paromomycin;Pathogenesis;Pathway interactions;Patients;Persons;Phagocytes;Phlebotominae;Phlebotomus;Post Kala-Azar Dermal Leishmaniasis;potential biomarker;preference;Prevention strategy;Proliferating;Public Health;Recommendation;Reporting;Research;Rest;Risk;Risk Factors;Seasons;Serology;single-cell RNA sequencing;Site;Skin;skin lesion;Soil;Somalia;Source;South Sudan;Spleen;Sudan;transcriptome;transmission process;treatment comparison;treatment response;Tropism;Uganda;vector;vector competence;Vector Ecology;Visceral Leishmaniasis;whole genome

PROJECT_TITLE: A multidisciplinary approach to study ecotypes driving transmission and pathogenesis of Visceral Leishmaniasis (VL) and Post kala-azar dermal leishmaniasis (PKDL) in Eastern Africa


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Prevention

ORG_CITY: KAMPALA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES

PHR: Project Narrative. Implementation science (ImS) is key to addressing the persistent challenges to HIV elimination in Uganda, but research capacity is still limited. Building on existing partnerships between Makerere University (MU), its affiliated HIV programs and the University of California, San Francisco, we have established a pioneer ImS Research Training Program at MU, built a strong foundation for ImS in Uganda, and influenced practices along the cascade of HIV care. The Program focus of the next period is to create sustained growth of the ImS research environment at MU and the application of ImS to HIV research and service delivery on a larger scale in Uganda. 1|Page

PI_NAMEs: KAMYA, MOSES ROBERT (contact);SEMITALA, FRED C

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Aging;AIDS prevention;California;care systems;career;Caring;Clinical Trials;comorbidity;Decision Making;Degree program;Developing Countries;Disease;Doctor of Philosophy;efficacious intervention;Eligibility Determination;Emergency Situation;Environment;Epidemic;European;evidence base;Face;Faculty;field study;Foundations;Funding;Geography;Growth;HIV;HIV/AIDS;implementation science;improved;Infection;Institution;Leadership;Master of Science;meetings;men;Mentorship;mortality;Outcome;Policies;Policy Maker;Population;pre-exposure prophylaxis;Prevention;prevention service;programs;Public Health;Research;Research Training;Resources;response;Risk;San Francisco;service delivery;Testing;Training;Training Programs;transmission process;treatment services;Uganda;United States National Institutes of Health;Universities;Viral;Viral Load result;virtual;Work;Youth

PROJECT_TITLE: Building Implementation Science Capacity at Makerere University to Strengthen the Response to the HIV/AIDS Epidemic in Uganda


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Kidney Disease;Pediatric;Prevention;Urologic Diseases

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: PROJECT NARRATIVE Urinary tract obstruction (UTO) during fetal development is the most common cause of chronic kidney disease in children. Research now suggests that a specialized cell population -- called renal urothelium – shields the kidney from injury during UTO. By enhancing our understanding of renal urothelium and its protective actions, we can develop new ways to detect and treat kidney injury in children with UTO.

PI_NAMEs: BECKNELL, BRIAN  (contact)

PROGRAM_OFFICER_NAME: GIPSON, DEBBIE SUE

PROJECT_TERMS: Acceleration;Address;Apical;Area;Attenuated;Basement membrane;Biological Markers;biomarker identification;biomarker validation;Bowman's space;Cells;Cessation of life;Child;Childhood;Childhood Injury;Chronic Kidney Failure;Cre-LoxP;Cytoplasm;Cytoprotection;Data;diagnostic biomarker;Disease Progression;early detection biomarkers;Enhancers;Evaluation;Exhibits;experience;Fetal Development;Generations;genetic approach;Goals;improved;indexing;inducible Cre;Injury;Injury to Kidney;Intervention;keratin 5;keratinocyte growth factor;Kidney;Kidney Diseases;kidney dysfunction;Kidney Failure;Knowledge;Measures;Medical;Messenger RNA;Modeling;mouse model;Mus;novel;novel diagnostics;Obstruction;Operative Surgical Procedures;Outcome;Patient Care;patient stratification;Patients;Pharmacologic Substance;Pioglitazone;Play;Population;Pre-Clinical Model;prevent;Production;progenitor;prognostic;Proteins;Publishing;Research;response;risk stratification;Role;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;tongue papilla;Ureteral obstruction;urinary;urinary tract obstruction;Urine;Urologic Surgical Procedures;Urothelial Cell;urothelial injury;Urothelium;Work

PROJECT_TITLE: Novel roles for urothelium during urinary tract obstruction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-B(90)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Neurosciences;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: WINSTON-SALEM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE Addiction to tobacco products is exceedingly common in the United States, and nicotine withdrawal and subsequent relapse is a significant contributor to the addiction process. The goal of this project is to leverage our well-qualified research team, our innovative tools, and our incisive methods to identify mechanisms that support tobacco addiction. By identifying these mechanisms, our project will promote the development of new and more effective strategies to help people quit smoking.

PI_NAMEs: DRENAN, RYAN MICHAEL (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Abstinence;addiction;Affect;Alkaloids;Area;Attenuated;Award;Behavior;Behavioral;biophysical techniques;Brain;Cessation of life;cholinergic;Cholinergic Receptors;Chronic;Cigarette;Cue-induced relapse;Dendritic Spines;designer receptors exclusively activated by designer drugs;Development;economic cost;Effectiveness;Electronic Nicotine Delivery Systems;Electrophysiology (science);Emotional;experimental study;Fiber;Fluorescence;Fostering;Genetic;Goals;Habenula;Health;hindbrain;Hour;Human Activities;Hypertension;Image;improved;innovation;Intake;interpeduncular nucleus;Intravenous;Knowledge;Lead;Learning;Malignant neoplasm of lung;Medial;Memory;Methods;Modeling;Molecular;Moods;neurobiological mechanism;Neurobiology;Neurons;Nicotine;nicotine cessation;nicotine craving;Nicotine Dependence;nicotine exposure;nicotine seeking behavior;nicotine self-administration;Nicotine Withdrawal;Nicotinic Receptors;novel;Optics;patch clamp;Pathway interactions;Persons;Pharmaceutical Preparations;Pharmacogenetics;pharmacologic;Pharmacology;Pharmacotherapy;Photometry;Physical Dependence;Physiology;Population;pre-clinical;preventable death;Process;Property;Prosencephalon;Pulmonary Emphysema;Qualifying;Rattus;Receptor Up-Regulation;receptor upregulation;Relapse;relapse risk;Research;research study;response;Rewards;Role;Self Administration;Signal Transduction;Slice;Smoker;Smoking;smoking cessation;System;Therapeutic;Time;Tobacco Dependence;tobacco products;Tobacco use;Tobacco Use Cessation;tool;transmission process;two photon microscopy;two-photon;United States;vaping;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Examining nicotine relapse in the habenulo-interpeduncular system

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Huntington's Disease;Lymphatic Research;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Huntington's disease (HD) is a neurodegenerative disorder that presents with progressive motor, psychiatric, and cognitive symptoms leading to early disability and mortality. No treatments to delay the onset or slow the disease progression exist yet. This project will provide fundamental insights into the role of the glymphatic system in HD and may reveal a mechanistic basis for identifying new therapeutics as well as potential biomarkers for HD.

PI_NAMEs: DUAN, WENZHEN  (contact);XU, JIADI

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Acceleration;Address;alpha synuclein;Amyloid beta-Protein;aquaporin 4;Astrocytes;Attenuated;base;Behavioral;Blood Vessels;Brain;Brain Diseases;Brain Pathology;Cerebrospinal Fluid;cerebrospinal fluid clearance;cognitive function;Data;density;Deposition;Development;disability;Disease;disease model;Disease Progression;Drainage procedure;Drug Targeting;effective therapy;extracellular;Fluorescence;Foundations;Glucose;glymphatic clearance;glymphatic dysfunction;glymphatic function;glymphatic system;Goals;Human;Huntington Disease;Huntington gene;Image;Image Enhancement;Imaging Techniques;Impairment;improved;in vivo;insight;Intercellular Fluid;knock-down;Knockout Mice;Magnetic Resonance Imaging;Measures;Membrane;Metabolic;Methods;minimally invasive;Molecular;Monitor;mortality;Motor;motor deficit;motor symptom;mouse model;Mus;mutant;Neurobehavioral Manifestations;Neurobiology;Neurodegenerative Disorders;Neurons;neuropathology;new therapeutic target;novel therapeutics;overexpression;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Physiologic pulse;potential biomarker;prevent;protein aggregation;protein complex;Proteins;psychiatric symptom;Role;screening;solute;Spin Labels;success;syntrophin;System;Techniques;Testing;therapy development;Tracer;Transgenes;Waste Products;wasting;Water;water channel

PROJECT_TITLE: Emerging role of glymphatic clearance in Huntington's disease


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: SAN FRANCISCO

ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

PHR: The proposed study addresses insomnia and posttraumatic stress disorder (PTSD), issues of critical importance that are related to Veterans’ social and occupational functioning and overall health. Insomnia is associated with a host of poor functional outcomes, and has long-term ramifications for Veterans’ health and wellbeing as they mature. Given that poor sleep is one of the most common concerns among Veterans, a behavioral treatment that directly addresses insomnia in this group is of utmost importance to the VA. Veterans report serious barriers to seeking care in mental health clinics, where behavioral insomnia treatment is most commonly provided, and that those most in need are least likely to seek services. Consequently, this treatment is designed to respond to all of these issues by examining the rehabilitative efficacy of a brief video- and telephone-facilitated treatment for insomnia for Veterans with PTSD.

PI_NAMEs: MAGUEN, SHIRA  (contact)

PROJECT_TERMS: Activities of Daily Living;Address;Aftercare;Alcohol consumption;Appointment;Arousal;Attention;Behavior Therapy;Behavioral;behavioral sleep intervention;care seeking;Caring;Clinic;Clinical;clinically significant;Cognitive Therapy;combat;common symptom;comparison group;Conditioned Insomnia;Control Groups;Data;depressive symptoms;design;Diagnosis;Diagnostic;diaries;DSM-V;efficacy testing;emotion regulation;evidence base;Evidence based treatment;Exclusion;executive function;Feeling suicidal;follow-up;functional outcomes;Goals;Health;Health behavior;high risk;Hour;improved;indexing;Individual;Interview;Iraq;Manuals;Measurement;Measures;Mental Health;Mental Health Services;Methods;Military Personnel;Monitor;Muscle relaxation phase;Nightmare;Occupational;Outcome;Paper;Participant;Patient Self-Report;Patients;Personal Satisfaction;Pharmaceutical Preparations;Play;poor sleep;Post-Traumatic Stress Disorders;primary outcome;Productivity;psychosocial;Psychotherapy;Quality of life;Randomized;Randomized, Controlled Trials;reducing suicide;Rehabilitation Outcome;Rehabilitation therapy;Relaxation Therapy;Reporting;Risk;risk mitigation;Role;secondary outcome;Services;Severities;Short-Term Memory;Sleep;Sleep Disorders;Sleep disturbances;sleep health;sleep onset;Sleeplessness;Smoking;social;social stigma;Stimulus;suicidal;suicidal risk;Suicide;Symptoms;Target Populations;Telephone;telephone based;telephone session;Testing;Time;Trauma;treatment group;Veterans;video session;Visit;War

PROJECT_TITLE: Brief Behavioral Treatment for Insomnia in Veterans with Posttraumatic Stress Disorder

STUDY_SECTION: RRDE

STUDY_SECTION_NAME: Behavioral Health & Social Reintegration[RRDE]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Cancer;Clinical Research;Drug Abuse (NIDA only);Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Physical Activity;Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The ABCD Consortium will use multimodal brain imaging, cognitive and clinical assessments, bioassays, mobile monitoring, and careful assessment of substance use, environment, psychopathological symptoms, and social functioning in 11,878 adolescents followed over 10 years to determine the effects of substance use on adolescent brain and cognitive development. Our ABCD Data Analysis, Informatics and Resource Center (DAIRC) will maintain and update harmonized MRI protocols across sites and scanners, perform quality control of raw and derived data, and implement the informatics and computational infrastructure needed for the overall project.

PI_NAMEs: DALE, ANDERS M (contact)

PROGRAM_OFFICER_NAME: DEEDS, BETHANY

PROJECT_TERMS: 10 year old;Address;Adolescent;Affect;Alcohols;Athletic Injuries;Biological Assay;Brain;Brain imaging;Caffeine;Calibration;Childhood;Clinical assessments;Cognitive;cognitive development;cognitive testing;cohesion;cohort;Communities;Complex;Computer Analysis;computer infrastructure;Computer software;computerized;connectome;Data;Data Analyses;Data Analytics;data archive;Data Collection;data exploration;data quality;data resource;data sharing;design;Development;Diffusion Magnetic Resonance Imaging;digital platform;Education;Emotional;Enrollment;Ensure;Environment;Epidemiology;experience;follow-up;Functional Magnetic Resonance Imaging;Funding;Future;gene interaction;Genetic study;Guidelines;handheld mobile device;health assessment;high standard;Human;Image;improved;Individual;Informatics;informatics infrastructure;Information Dissemination;Infrastructure;infrastructure development;Link;Machine Learning;Magnetic Resonance Imaging;Marijuana;Measures;Mental disorders;Mental Health;Methods;mobile computing;Modality;Modeling;Monitor;multidimensional data;multimodality;National Institute of Mental Health;Neurocognition;Neurocognitive;neuroimaging;Nicotine;novel;Online Systems;open data;Outcome;Parents;Participant;Physical activity;physical conditioning;Procedures;Process;Protocols documentation;Quality Control;Questionnaires;Recommendation;recruit;Research;Research Personnel;Research Project Grants;Resources;Rest;retention rate;Role;Sampling;Severities;Site;Sleep;Social Functioning;Specific qualifier value;Standardization;Statistical Data Interpretation;substance use;success;Surveys;Symptoms;Technology;Technology Assessment;Time;tool;Triplet Multiple Birth;tv watching;Twin Multiple Birth;Update;web portal;Youth

PROJECT_TITLE: ABCD-USA Consortium: Data Analysis, Informatics and Resource Center


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: MISSISSIPPI STATE

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: MISSISSIPPI STATE UNIVERSITY

ORG_STATE: MS

PHR: NARRATIVE There is a well-established need (illustrated effectively by the COVID-19 pandemic) for veterinarian-scientists who can investigate the transmission of animal disease microbes to humans. This project will provide veterinary students an opportunity to conduct a meaningful research project and we expect that some of them will pursue additional research training and will contribute to the biomedical research enterprise.

PI_NAMEs: KAPLAN, BARBARA LEE-FAUBERT (contact);SAMUEL, TEMESGEN

PROJECT_TERMS: Accreditation;African;Biomedical Research;career development;Collaborations;college;Communicable Diseases;Computational Biology;Educational Activities;Educational Curriculum;Ensure;Epidemiology;experience;Faculty;Food Safety;functional genomics;Funding;Genomics;Goals;Grant;Individual;Institution;interest;International;Joints;Leadership;Mentorship;Mississippi;National Research Service Awards;Oncology;Positioning Attribute;Preparation;programs;recruit;Research;Research Personnel;Research Training;Students;summer research;Time;Toxicology;Training;training opportunity;Translational Research;Universities;Veterinarians;Veterinary Medicine

PROJECT_TITLE: Summer Research Experience for Veterinary Students


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE New therapeutic strategies to enhance immunotherapy responses are desperately needed for small cell lung cancer (SCLC), a largely immune “cold” cancer for which outcomes have remained virtually unchanged for thirty years. Our preliminary data indicate that DNA damaging therapies (such as PARP inhibitors) may induce changes in the immune microenvironment that are distinct between SCLC subtypes or other biomarker-defined groups. This proposal will investigate therapeutic vulnerabilities of distinct SCLC subtypes to combinations of DNA damaging agents or replication stress targeting with immune checkpoint blockade and has the potential to be rapidly translated into effective, biomarker-driven approaches for patients.

PI_NAMEs: BYERS, LAUREN AVERETT (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Address;advanced disease;Aftercare;BETA2 protein;Bioinformatics;Biological Markers;Biological Models;biomarker driven;Biopsy;blood-based biomarker;cancer cell;Cancer Patient;cancer subtypes;Cell Communication;chemotherapy;Chest;Cisplatin;Clinical;clinical predictors;Clinical Trials;co-clinical trial;Combination immunotherapy;Data;Development;Disease;DNA Damage;Drug Targeting;Gays;humanized mouse;Immune;immune checkpoint blockade;Immune response;Immunotherapy;improved;in vivo;inhibitor;Investigation;longitudinal analysis;Malignant Neoplasms;Mediating;Methods;Modeling;molecular subtypes;multidisciplinary;Neoplasm Circulating Cells;novel;novel therapeutic intervention;novel therapeutics;Outcome;Pathway interactions;patient derived xenograft model;patient population;Patients;Pharmaceutical Preparations;Platinum;Play;Poly(ADP-ribose) Polymerase Inhibitor;predictive marker;Relapse;replication stress;Reporting;Research;Resistance;resistance mechanism;response;Role;Sampling;Selection for Treatments;small cell lung carcinoma;Specimen;Testing;Therapeutic;Translating;treatment response;tumor;tumor heterogeneity;Tumor Immunity;tumor immunology;tumor microenvironment;tumor-immune system interactions;virtual;working group;Xenograft Model;Xenograft procedure

PROJECT_TITLE: DNA damaging therapy and immune response in small cell lung cancer subtypes

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases

ORG_CITY: LEWISBURG

ORG_NAME: BUCKNELL UNIVERSITY

PHR: PROJECT NARRATIVE In the short term, this project will contribute to our understanding of why bats in Africa can serve as hosts for diseases that can spill over to humans. We will learn what physiological properties of bats allow them to carry viruses without getting sick themselves. In the long term, this project will lead to applications to prevent the spillover of infections like Ebola and coronavirus to humans.

PI_NAMEs: FIELD, KENNETH A;REEDER, DEEANN  (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Achievement;Address;Adjuvant;Africa;African;Antibody Formation;antigen challenge;antiviral immunity;Area;Bacterial Antigens;Behavior;Behavioral Mechanisms;Body Temperature;Characteristics;Chiroptera;Coronavirus;Disease;disease model;Disease Reservoirs;Ebola;Ebola Hemorrhagic Fever;Ebola virus;Ecology;Epidemiology;Equilibrium;Exhibits;experimental study;Female;Fever;Filovirus;Goals;Habitats;Human;Hyperthermia;Immune;immune resistance;Immune response;Immune signaling;Immune Tolerance;Immunologics;Infection;innate immune pathways;innovation;insight;Learning;Link;malaria infection;male;Metabolic;Metabolism;Molecular;natural hypothermia;novel;Paramyxovirus;pathogen;pathogenic bacteria;pathogenic virus;Pathology;Pathway interactions;Phenotype;Physiologic Thermoregulation;Physiological;Physiological Adaptation;Physiology;Play;Population;predicting response;pregnant;prevent;Primates;Property;Proxy;Recording of previous events;Resistance;response;Retinal blind spot;Risk;RNA Virus Infections;RNA Viruses;Rodent;Role;Sampling;SARS coronavirus;Signal Transduction;Study models;Temperature;Testing;transmission process;Uganda;Viral;Viral Antigens;Viral reservoir;Virulent;Virus;Virus Diseases;Virus-like particle;Work;Zoonoses

PROJECT_TITLE: Tolerance and resistance responses of African bats to viral antigens: Immunological tradeoffs in zoonotic reservoir hosts.

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Kidney Disease;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Diabetic kidney disease is an enormous and growing public health burden, and significant gaps in guideline- recommended care delivery exist for patients with DKD. This project aims to design and pilot an intervention of targeted, proactive, electronic nephrology consultation to improve care delivery for primary care patients with diabetic kidney disease in an urban public health system, with special attention toward minimizing racial and ethnic disparities. Through this proposal, insights gained from key stakeholders across multiple health delivery systems, as well as preliminary data and implementation experience, will inform the design and implementation of larger system-scale interventions for improving care delivery for diabetic kidney disease and preventing its complications, including cardiovascular disease, kidney disease progression, and kidney failure.

PI_NAMEs: CHU, CHI  (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: acceptability and feasibility;Address;Affect;Attention;burden of illness;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;care delivery;care outcomes;career;Caring;Chronic Kidney Failure;clinical decision support;Collaborations;Consultations;Data;design;Diabetic Nephropathy;Dimensions;Disease Management;Disease Progression;disease registry;Disparity;disparity reduction;Economic Burden;Education;Effectiveness;effectiveness evaluation;effectiveness study;Electronic Health Record;Electronics;Elements;Eligibility Determination;End stage renal failure;Epidemiology;Equity;ethnic disparity;ethnic minority;Ethnic Population;experience;Failure;Foundations;Glucose;Goals;Guidelines;Health;health care delivery;health care disparity;health disparity;health equity;Health system;Healthcare;Healthcare Systems;implementation science;implementation study;improved;inhibitor;insight;Integrated Health Care Systems;Intervention;intervention delivery;Intervention Studies;Interview;Kidney;Kidney Diseases;Kidney Failure;Learning;medical specialties;Mentors;Modeling;models and simulation;Morbidity - disease rate;mortality;Nephrology;novel therapeutics;patient outreach;Patient Selection;Patients;Pattern;Persons;Pharmaceutical Preparations;Pilot Projects;Population;population health;post implementation;pressure;prevent;Prevention;Primary Care;primary care clinician;primary care patient;primary care provider;primary care team;Provider;Public Health;Qualitative Methods;Qualitative Research;racial disparity;racial minority;racial population;Random Allocation;Recommendation;Records;Research;Research Methodology;research study;Resources;response;Risk Factors;Risk Reduction;San Francisco;Scientist;Self Management;Shoulder;skills;Sodium;Specialist;Structure;success;Surveys;symporter;System;therapy design;Touch sensation;Training;treatment as usual;treatment pattern;uptake;urban public health;Variant;Veterans Health Administration;Visit

PROJECT_TITLE: Targeted Automated Nephrology e-Consultation for Diabetic Kidney Disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE This research aims to understand why some retinal ganglion cells survive degeneration when their neighbors perish, and to leverage these differences into new treatments for retinal ganglion cell degenerating diseases like glaucoma and optic neuropathy. We will focus on pathways related to cellular homeostasis, which are associated with multiple forms of age related neurodegeneration. The outcome will advance our understanding of neurodegeneration in retinal ganglion cells and begin the development of novel treatment strategies for these blinding diseases.

PI_NAMEs: WILLIAMS, PHILIP RAYMOND (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Affect;age related neurodegeneration;Animal Model;Axon;axon injury;Axotomy;Biological Assay;Biosensor;Blindness;Brain;Caliber;Cell Death;Cell Energetics;Cell Survival;cell type;Cells;Cessation of life;Clinical;Coping Skills;Data;Degenerative Disorder;Development;Diabetic Neuropathies;Diabetic Retinopathy;Disease;Disease Progression;Endoplasmic Reticulum;experimental study;Eye;Fingerprint;Foundations;Gene Expression;Genes;genetic manipulation;Glaucoma;Goals;Heterogeneity;Homeostasis;Human;human disease;human model;Image;imaging approach;improved;in vivo;in vivo imaging;Individual;Intervention;knock-down;Legal Blindness;legally blind;Maintenance;Measurement;Measures;Metabolic;Metabolism;Mitochondria;Modeling;Mus;Nature;Nerve Crush;Nerve Degeneration;neuron loss;neuronal survival;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Optic Nerve;optic nerve disorder;Optic Nerve Glioma;Optic Nerve Injuries;Optic Neuritis;Outcome;overexpression;Pathway interactions;Patients;pharmacologic;Phenotype;Physiologic Intraocular Pressure;Population;Population Heterogeneity;Predisposition;preservation;prevent;Production;Property;Proteins;Regulation;Repression;Research;resilience;Resolution;response;Rest;Retina;retinal ganglion cell degeneration;Retinal Ganglion Cells;retinal neuron;Role;sample collection;sight restoration;Source;survival outcome;Testing;Therapeutic Agents;Time;trait;Translating;Trauma;treatment strategy;two-photon;Vision

PROJECT_TITLE: Identifying and leveraging strategies of inherently resilient retinal neurons to treat degeneration

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Pain;Neurosciences;Pain Research;Physical Injury - Accidents and Adverse Effects

ORG_CITY: DURHAM

ORG_DEPT: ORTHOPEDICS

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE An estimated 3.9 million fractures occur in the US with an annual economic burden of $116.9 billion in combined medical expenses and work loss. Management of pain arising from orthopedic fractures remains a challenge, as common analgesic medications either interfere with healing or possess potential for addiction. Completion of this proposal will establish a new therapeutic strategy for the care of pain due to orthopedic surgery and fractures.

PI_NAMEs: VARGHESE, SHYNI  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: 3-Dimensional;Acceleration;Acids;Acute Pain;addiction liability;Address;Adenosine;Adenosine A1 Receptor;Affect;Afferent Neurons;Agonist;Analgesics;Animals;antagonist;Appearance;Attenuated;Behavior;behavior test;Biocompatible Materials;Bone callus;bone fracture repair;Bone Injury;Brain-Derived Neurotrophic Factor;Buprenorphine;Caring;Central Nervous System;chronic pain;Clinical;conditional knockout;crosslink;Cyclic AMP;Data;Dependence;Development;Dinoprostone;Dissociation;Dose;Economic Burden;Environment;Esthesia;experimental study;extracellular;Facial Expression;Fracture;gait examination;Gel;Goals;Harvest;healing;Hyaluronic Acid;improved;In Vitro;in vivo;Injectable;Injury;Ion Channel;knock-down;Light;Locomotion;Matrix Metalloproteinases;Mechanics;Mediating;Medical Care Costs;Membrane Potentials;Microfluidic Microchips;Microfluidics;Mus;Nerve;neurite growth;Neurons;Neuropeptides;neurotrophic factor;Nociceptors;Non-Steroidal Anti-Inflammatory Agents;novel therapeutic intervention;novel therapeutics;Opioid;Orthopedic Surgery;Orthopedics;Osteogenesis;Pain;Pain management;pain reduction;pain relief;pain sensitivity;Peripheral;Peripheral Nerves;Pharmaceutical Preparations;Prevalence;Production;Purinergic P1 Receptors;receptor;receptor expression;Receptor Signaling;Regulation;Role;scaffold;Sensory Receptors;Series;side effect;Signal Transduction;Site;skeletal;skeletal tissue;Small Interfering RNA;small molecule;Stains;Stimulus;success;Testing;Therapeutic;Therapeutic Agents;therapeutically effective;tibia;Tibial Fractures;Tissues;transcriptome sequencing;transcriptomics;Trauma;TRPV1 gene;Weight-Bearing state;Work

PROJECT_TITLE: Modulation of local adenosine signaling to attenuate fracture pain


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetic Testing;Genetics;Human Genome;Neurosciences;Prevention;Rare Diseases

ORG_CITY: TORONTO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY HEALTH NETWORK

ORG_STATE: ON

ORG_ZIPCODE: M5G 2C4

PHR: PROJECT NARRATIVE Diagnosis of brain cancers requires high-risk neurosurgery to obtain tissue. Tumor cells shed DNA into the blood circulation and molecular analysis of this DNA may obviate the need for invasive surgeries. The work proposed here aims to demonstrate that methylation profiling of circulating DNA can accurately diagnose, discriminate, monitor response to treatment, and detect early tumor recurrence in both primary and metastatic CNS tumors, leading to a paradigm-shift in patient management.

PI_NAMEs: DE CARVALHO, DANIEL ;ZADEH, GELAREH  (contact)

PROGRAM_OFFICER_NAME: GANGULY, ANIRUDDHA

PROJECT_TERMS: accurate diagnosis;Antibodies;Anxiety;Biological Markers;Blood Circulation;Blood Tests;Brain;Brain Mass;Brain Neoplasms;brain surgery;Breast;cell free DNA;Cells;Central Nervous System;Central Nervous System Neoplasms;Cephalic;Cerebrospinal Fluid;circulating DNA;Circulation;Classification;Clinical;clinical diagnosis;cohort;Data;Development;Diagnosis;Differential Diagnosis;Discrimination;Disease;DNA;DNA analysis;DNA Methylation;DNA methylation profiling;Early Diagnosis;Early Intervention;Evaluation;experience;Glioma;hemangiopericytoma;high risk;Immunoprecipitation;interest;liquid biopsy;Liquid substance;Lung;Lymphoma;Malignant - descriptor;Malignant neoplasm of brain;Malignant neoplasm of central nervous system;Malignant Neoplasms;Medicine;Melanoma;meningioma;Metastatic malignant neoplasm to brain;Methylation;methylation pattern;methylome;Modeling;Molecular Analysis;Monitor;Morbidity - disease rate;mortality;Mutation;Nature;Neoplasm Metastasis;neoplastic cell;neuro-oncology;Neurologic;neurosurgery;Non-Invasive Detection;noninvasive diagnosis;novel;novel strategies;Oncology;operation;Operative Surgical Procedures;optimal treatments;Outcome;Patient Monitoring;Patients;Plasma;Plasma Cells;predictive modeling;Procedures;Prognosis;prognostic;prognostication;prospective;Protocols documentation;Publishing;radiological imaging;Recurrence;Recurrent tumor;Repeat Surgery;response biomarker;Risk;Sampling;Shapes;Signal Transduction;Site;Specimen;Stratification;success;System;Techniques;Tissues;treatment response;tumor;tumor diagnosis;tumor DNA;Tumor Markers;tumor progression;Tumor Tissue;Work

PROJECT_TITLE: Establishing the clinical utility of cell-free tumor DNA methylation profiling as a reliable liquid biopsy approach in brain tumors

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Comparative Effectiveness Research;Conditions Affecting the Embryonic and Fetal Periods;Cost Effectiveness Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE Opioid use disorder in pregnancy has more than quadrupled in the last two decades, resulting in adverse pregnancy and birth outcomes and a subsequent rise in healthcare utilization. This proposal seeks to identify optimal treatment and care processes for pregnant women with opioid use disorder.

PI_NAMEs: LEECH, ASHLEY A (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: addiction;Address;Advisory Committees;Affect;Age;Award;Birth;Budgets;Buprenorphine;Calibration;care delivery;career;Career Mobility;Caring;Characteristics;Child;Clinical;clinical practice;Clinical Trials;Consumption;cost;Cost Effectiveness Analysis;Decision Analysis;Decision Making;Doctor of Philosophy;Drug Withdrawal Symptoms;Environment;evidence base;evidence based guidelines;Expenditure;Exposure to;Family;fetal;follow-up;Frequencies;Funding;Future;Geography;Goals;Grant;Guidelines;Health;Health Benefit;health care delivery;Health Care Sector;health care service utilization;Health Policy;health related quality of life;Health Resources;Health Services;Health Services Accessibility;Health system;Healthcare;Healthcare Systems;Hospitalization;Implant;Improve Access;improved;in utero;Infant;Infant Health;infant outcome;Injectable;Intervention;Leeches;Link;marginalization;Maternal and Child Health;Maternal Exposure;Maternal Health;maternal outcome;Mathematical Model Simulation;Measures;Medical;medical schools;Mentors;Mentorship;Methadone;Methodology;Methods;Modeling;models and simulation;mortality;Naltrexone;Neonatal;Neonatal Abstinence Syndrome;Nonpharmacologic Therapy;Operations Research;Opioid;Opioid agonist;opioid agonist therapy;opioid use;opioid use disorder;opioid withdrawal;optimal treatments;Outcome;overdose risk;Patients;Pattern;Personal Satisfaction;Pharmacotherapy;Policies;Policy Maker;Population;Pregnancy;Pregnant Women;Prenatal care;Process;professor;Provider;Public Health;Quality of life;Recommendation;Recovery;Relapse;Reproducibility;reproductive;Research;Research Personnel;Research Priority;Resources;Risk;Risk Reduction;Science;Scientist;side effect;Syndrome;Techniques;Training;treatment optimization;Treatment outcome;treatment strategy;Uncertainty;Universities;Withdrawal;Woman

PROJECT_TITLE: Advancing Treatment Outcomes for Pregnant Women with Opioid Use Disorder

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pediatric;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE The ABCD Study consortium uses multimodal brain imaging, cognitive and clinical assessments, bioassays, mobile monitoring, and careful assessment of substance use, environment, psychopathological symptoms, and social functioning in 11,878 9-10 year-olds to be followed over 10 years, to determine the effects of substance use on adolescent brain and cognitive development. This ABCD Research Project Site will follow and assess participants enrolled in the study. These data will be shared with the scientific community to address a comprehensive range of questions concerning youth development.

PI_NAMEs: FOXE, JOHN J (contact);FREEDMAN, EDWARD G

PROJECT_TERMS: 10 year old;Address;Adolescence;Adolescent;adolescent substance use;Adult;adverse outcome;Affect;Age;Alcohol consumption;Alcohols;Anxiety;assessment application;Athletic Injuries;Behavior;Behavioral;Bioinformatics;Biological;Biological Assay;Biology;Brain;Brain imaging;Caffeine;Calendar;Cannabis;Child;Child Health;Childhood;Clinical assessments;Cognition;Cognitive;cognitive development;cognitive testing;cohort;college;Communities;Country;Data;Data Analyses;Decision Making;design;Development;emerging adult;Emotional;emotional factor;Enrollment;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiology;Ethics;Event;experience;Feeling suicidal;Female;follow-up;Funding;gene interaction;Genetic;Health;Impairment;Individual;Informatics;informatics infrastructure;Interview;Life;Link;Longitudinal Studies;marijuana use;Mental Depression;Mental disorders;Mental Health;Methodology;Methods;mobile application;mobile computing;Monitor;multimodality;neural;Neurocognition;Neurocognitive;neurodevelopment;neuroimaging;Neuropsychological Tests;novel;Occupations;Outcome;Parents;Participant;participant enrollment;participant retention;Pathway interactions;Persons;Physical activity;physical conditioning;Privatization;Process;Protocols documentation;Psychopathology;Qualifying;recruit;Recurrence;Registries;Research;research and development;Research Personnel;Research Project Grants;Resource Informatics;Resources;response;retention rate;Risk;Role;Sampling;Schools;Science;Secure;Severities;Siblings;Site;Sleep;sleep pattern;social;Social Functioning;Social isolation;social media;Specific qualifier value;Sports;Standardization;substance use;Symptoms;Technology;Teenagers;Telephone;temporal measurement;Text;Time;Tobacco;Tobacco use;Training;Traumatic Brain Injury;trend;Triplet Multiple Birth;tv watching;Twin Multiple Birth;United States;Universities;vaping;Video Games;young adult;Youth

PROJECT_TITLE: 16/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT UNIVERSITY OF ROCHESTER


PHR: Follicular lymphoma (FL) is the second most common form of non-Hodgkin’s lymphoma, and is characterized by recurrent mutations in genes that encode histone modifying enzymes. Mutations in the histone acetyltransferase, CREBBP, are present in approximately two thirds of cases and are acquired as an early event in disease evolution. Here we aim to investigate the molecular mechanisms by which CREBBP mutations alter the epigenome of FL and cooperate with other histone modifying enzymes such as EP300 and EZH2.

PI_NAMEs: GREEN, MICHAEL RICHARD (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Acetyl Coenzyme A;Acetylation;Acetyltransferase;Alleles;Amino Acids;B-Cell Development;B-Cell Lymphomas;B-Lymphocytes;BCL6 gene;Binding;Biochemical;Biology;Cell Line;Cell Survival;Cells;Chromatin;Chromatin Remodeling Factor;Clustered Regularly Interspaced Short Palindromic Repeats;Coenzyme A;combinatorial;Compensation;Complex;conditional knockout;CREBBP gene;Darkness;Deacetylation;Development;Disease;DNA Damage;efficacy evaluation;Enhancers;Enzymes;EP300 gene;Epigenetic Process;epigenetic regulation;epigenome;Etiology;Event;Evolution;EZH2 gene;Failure;Follicular Dendritic Cells;Follicular Lymphoma;Frameshift Mutation;Gene Expression;Gene Mutation;Genes;genetic corepressor;HDAC3 gene;Helper-Inducer T-Lymphocyte;Histone Acetylation;histone acetyltransferase;Histones;Immunoglobulins;improved;in vitro Assay;Indolent;inhibitor;Knock-out;Light;Link;Lymphoma cell;Lymphomagenesis;Lysine;Malignant Neoplasms;Maps;Mediating;Methylation;Missense Mutation;Modeling;Molecular;molecular phenotype;mouse model;mutant;Mutation;mutational status;neglect;Non-Hodgkin's Lymphoma;novel;overexpression;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Phenotype;Play;Polycomb;prevent;programs;Proliferating;Proteins;recruit;Recurrence;Recycling;Repression;Repressor Proteins;response;Role;Structure of germinal center of lymph node;Tail;targeted agent;Therapeutic;transcription factor;Transgenic Mice;tumor

PROJECT_TITLE: Identifying/Targeting Mechanisms of Lymphomagenesis Driven by CREBBP Inactivation

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Services;Precision Medicine;Primary Health Care

PHR: Project Narrative My research agenda is to conduct patient-oriented research that advances understanding of overuse of healthcare among older adults. With the collaboration of junior investigators and other mentees, I will conduct research to understand how health care systems limit the harmful overuse of healthcare resources by their Medicare beneficiaries through their delivery of high quality primary care. The second set of projects involves development of tools to help clinicians to communicate more clearly with patients about heterogeneity of treatment effect in order to reduce the use of healthcare resources in patients unlikely to benefit from their use.

PI_NAMEs: SEGAL, JODI B. (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Academy;Address;Adult;aging process;beneficiary;care delivery;career;Caregivers;Caring;Clinic;Collaborations;Communication;Communication Tools;Communities;cost;Data;Decision Making;density;design;Diagnostic;Elderly;Epidemiologic Methods;Evaluation;Family;frailty;Funding;Goals;Health Status;Health system;Healthcare;Healthcare Systems;Heterogeneity;high risk;Hospital Units;improved;indexing;Individual;individual patient;individualized medicine;Intervention;Learning;Measures;Mediation;Mediator;Medicare;Medicare claim;Medicine;Mentors;method development;Methodology;Methods;Mid-Career Clinical Scientist Award (K24);Modeling;multiple chronic conditions;older adult;older patient;Outcome Measure;Overutilization of Health Services;Pathway interactions;patient oriented;patient oriented research;Patients;peer;Persons;Pharmaceutical Preparations;Phase;Physiological;Population;preference;prevent;Primary Care;Procedures;Process;Regimen;Reporting;Research;Research Personnel;Resources;Role;Self Care;Services;skills;Statistical Methods;Structure;System;Thinking;tool;tool development;treatment effect;Treatment outcome;United States;Variant;Visual;Work

PROJECT_TITLE: Towards Reduction of Harmful Overuse of Healthcare in Older Adults

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Clinical Research;Eye Disease and Disorders of Vision;Headaches;Migraine;Neurosciences;Pain Research;Physical Injury - Accidents and Adverse Effects;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: SALT LAKE CITY

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE: Post-traumatic headache (PTH) is the most common consequence of traumatic brain injury, and is frequently chronic and refractory to typical pain treatments. Autonomic and sensory dysfunction have been recognized in PTH and represent key, objectively measurable candidate disease markers. This proposal will use an innovative, multimodal approach to sensory and autonomic testing to identify clinically meaningful biomarkers for use in PTH diagnosis, disease monitoring, and the development of non-addictive treatments with the goal of reducing the overall health burden of PTH.

PI_NAMEs: CORTEZ, MELISSA  (contact)

PROGRAM_OFFICER_NAME: SYPEK, ELIZABETH IRENE

PROJECT_TERMS: Acute;Advisory Committees;Age;Applications Grants;Area;authority;Autonomic Dysfunction;Award;Biological;Biological Markers;Biometry;Brain Concussion;burden of illness;career;career development;Chronic;Chronic Headaches;chronic painful condition;Clinical;Clinical Research;Color;Colorimetry;Complex;Data;Development;Diagnosis;Diagnostic;Disabling;Disease;Disease Marker;Disease Progression;disorder risk;Early identification;Early Intervention;Early treatment;Environment;Exhibits;experience;Exposure to;Functional disorder;Goals;Headache;Headache Disorders;Health;improved;Incidence;Individual;Injury;innovation;insight;Institution;Learning;lens;Light;Lighting;Manuscripts;Measurable;Measures;Mediating;Mentored Patient-Oriented Research Career Development Award;Mentors;Migraine;mild traumatic brain injury;Monitor;multimodality;Nature;Nerve;Neurologist;Neurology;neurophysiology;novel;Ophthalmologist;Pain;Pain management;patient oriented;Patients;Pattern;persistent symptom;personalized approach;Persons;Phenotype;Photophobia;Photosensitivity;Physiological;Positioning Attribute;post intervention;Post-Traumatic Headaches;preference;primary outcome;progression risk;Psychophysics;Public Health;Pupil light reflex;Recovery;Refractory;Reporting;Research;Research Personnel;response;Risk;Screening procedure;secondary outcome;Sensory;sensory mechanism;Severity of illness;sex;signal processing;skill acquisition;skills;Stimulus;success;Symptoms;System;targeted treatment;Testing;Therapeutic;Traction;Training;Traumatic Brain Injury;treatment trial;Vision;Visual disability;Visual Psychophysics;Work

PROJECT_TITLE: Photophobia and Pupillary Autonomic Dysfunction as Biomarkers of Post-Traumatic Headache

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Networking and Information Technology R&D (NITRD)

ORG_CITY: MADISON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Public Health Statement  Laparoscopic surgery has continued to evolve and is now the gold standard approach for the majority of abdominal operations, offering numerous clinical benefits to patients. The current paradigm has many drawbacks in the visualization of the surgical field, causing lower operative efficiency. Our goal is to overcome these drawbacks and create a new paradigm in laparoscopic visualization by developing a flexible-view, immersive, three-dimensional imaging system. As a result, laparoscopic operative efficiency will be significantly improved.

PI_NAMEs: HEISE, CHARLES P;JIANG, HONGRUI  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TITLE: EasyVis: Flexible, immersive three-dimensional laparoscopic surgical visualization through multi-camera arrays

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Immunization;Immunotherapy;Orphan Drug;Pancreatic Cancer;Precision Medicine;Rare Diseases;Skin Cancer;Vaccine Related

ORG_DEPT: SURGERY

PHR: Conclusions drawn from a model system are only as valid as the understanding of that model system. Our plan to more clearly define the ability of an autologous, fully humanized mouse system to model human biology, immune-biology, and treatment response and toxicity would allow investigators to appropriately and robustly use this system for future, hypothesis-driven cancer research. It fulfils a critical translational gap in modeling human cancers in the context of an intact immune system. Our plan to rigorously validate this model, utilizing the NCI Oncology Models Forum to facilitate collaborations and make these models widely available, will create a tremendous resource for the oncology research community moving forward.

PI_NAMEs: FIELDS, RYAN C (contact);FLAVELL, RICHARD A

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Adaptive Immune System;Address;Animals;anti-cancer research;anti-CTLA4;anti-PD1 therapy;antigen-specific T cells;Antigens;Area;Autologous;Biological Models;Biology;Bone Marrow;cancer immunobiology;cancer immunotherapy;Cancer Model;cancer therapy;CD34 gene;Cells;checkpoint therapy;Clinical Oncology;Collaborations;Colorectal Cancer;Colorectal Neoplasms;Communities;Credentialing;Development;Early Diagnosis;Early treatment;effector T cell;Evaluation;Exposure to;Frequencies;Funding;Future;Goals;Grant;Human;Human Biology;human model;humanized mouse;Immune;immune checkpoint blockade;Immune response;Immune system;Immunocompetent;immunodeficiency;Immunological Models;Immunotherapy;improved;in vivo Model;Individual;Infrastructure;Innate Immune System;Institution;Leukocytes;Lymphocyte;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Melanoma;Melanoma patient;Melanoma Tumor;Modality;Modeling;Monitor;Morbidity - disease rate;mouse model;Mus;mutant;neoantigens;Neoplasm Metastasis;novel;Oncology;pancreatic neoplasm;patient derived xenograft model;patient response;Patient-Focused Outcomes;Patients;peptide based vaccine;peptide vaccination;Phenotype;pre-clinical;Pre-Clinical Model;precision oncology;predicting response;Progressive Disease;Radiation therapy;Regimen;Research;Research Personnel;Research Proposals;Resources;response;single-cell RNA sequencing;Source;Structure;success;System;T cell receptor repertoire sequencing;T cell response;T-Lymphocyte;Techniques;Therapeutic;Tissues;Toxic effect;translational oncology;Treatment Protocols;treatment response;Treatment-related toxicity;tumor;tumor growth;Vaccine Design;vaccine strategy;Work

PROJECT_TITLE: Advancing Precision Oncology in a Humanized, Fully Autologous Mouse Model

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-J(55)R]


ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PI_NAMEs: GARAVAN, HUGH P. (contact);POTTER, ALEXANDRA S

PROJECT_TERMS: 10 year old;Address;Adolescence;Adolescent;adolescent substance use;Adult;adverse outcome;Affect;Age;Alcohol consumption;Alcohols;Anxiety;assessment application;Athletic Injuries;Behavior;Behavioral;Bioinformatics;Biological;Biological Assay;Biology;Brain;Brain imaging;Caffeine;Calendar;Cannabis;Child;Child Health;Childhood;Clinical assessments;Cognition;Cognitive;cognitive development;cognitive testing;cohort;college;Communities;Country;Data;Data Analyses;Decision Making;design;Development;emerging adult;Emotional;emotional factor;Enrollment;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiology;Ethics;Event;experience;Feeling suicidal;Female;follow-up;Funding;gene interaction;Genetic;Health;Impairment;Individual;Informatics;informatics infrastructure;Interview;Life;Link;Longitudinal Studies;marijuana use;Mental Depression;Mental disorders;Mental Health;Methodology;Methods;mobile application;mobile computing;Monitor;multimodality;neural;Neurocognition;Neurocognitive;neurodevelopment;neuroimaging;Neuropsychological Tests;novel;Occupations;Outcome;Parents;Participant;participant enrollment;participant retention;Pathway interactions;Persons;Physical activity;physical conditioning;Privatization;Process;Protocols documentation;Psychopathology;Qualifying;recruit;Recurrence;Registries;Research;research and development;Research Personnel;Research Project Grants;Resource Informatics;Resources;response;retention rate;Risk;Role;Sampling;Schools;Science;Secure;Severities;Siblings;Site;Sleep;sleep pattern;social;Social Functioning;Social isolation;social media;Specific qualifier value;Sports;Standardization;substance use;Symptoms;Technology;Teenagers;Telephone;temporal measurement;Text;Time;Tobacco;Tobacco use;Training;Traumatic Brain Injury;trend;Triplet Multiple Birth;tv watching;Twin Multiple Birth;United States;vaping;Video Games;young adult;Youth

PROJECT_TITLE: 19/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT UVM


ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE Gender diverse youth (GDY) who identify as Black, Indigenous, or People of Color (BIPOC), and those living in rural communities are more likely to experience mental health concerns than their peers. Additionally, GDY experience barriers to receiving care to affirm their identities, which has been shown to improve mental health. The goals of this study are to 1) better understand BIPOC and rural GDY’s care needs, 2) design a platform to support community providers in delivering care to GDY, and 3) conduct a study to explore the impact that use of this platform has on youth, their families, and their community providers.

PI_NAMEs: SEQUEIRA, GINA M (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Using telehealth to improve access to gender-affirming care for BIPOC and rural gender diverse youth

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Genetics;Regenerative Medicine

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: This work will increase understanding of developmental regulation during vertebrate tissue regeneration, and provide important perspective for comprehending, and perhaps changing, the existing limitations in regenerative capacity of human tissues.

PI_NAMEs: POSS, KENNETH D (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Adult;Alleles;Amphibia;Animals;appendage;Binding;Biological;blastema;candidate identification;Cardiac;Catalogs;Cell Proliferation;Cells;Chemicals;Chromatin;chromosome conformation capture;Code;Compensation;Complex;Dedications;deletion analysis;Development;Developmental Biology;Digit structure;Distal;Distant;DNA;DNA Sequence;Elements;Embryonic Development;Engineering;Enhancers;Event;experimental study;gene discovery;Gene Duplication;Gene Expression;Genes;Genetic;Genetic Enhancer Element;Genetic Transcription;Genome;genome-wide;Goals;human tissue;improved;Injury;innovation;insight;Leptin;Ligands;Limb structure;Link;Mesenchymal;Messenger RNA;Methodology;Methods;Molecular;Mutagenesis;mutant;Names;Natural regeneration;paralogous gene;Pattern;programs;Promoter Regions;Proteins;recruit;regeneration potential;regenerative;Regenerative capacity;regenerative healing;Regulation;Regulatory Element;screening;Shapes;skeletal;stem cells;Structure;teleost fish;Testing;tissue regeneration;tissue repair;Tissues;tool;Trans-Activators;transcription factor;Transcription Repressor;Transcriptional Activation;Transcriptional Silencer Elements;Transgenic Organisms;Work;Zebrafish

PROJECT_TITLE: Regulation of Appendage Regeneration in Zebrafish

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Diabetes;Genetics;Human Genome;Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Efforts to combat obesity with diet and exercise have not reversed the steady climb of body weight in western cultures over the last decades. This proposal aims to fight obesity by understanding and ultimately controlling fat tissue development and growth. The findings will highlight therapeutic targets against obesity, which affects up to 30% of the United States population and contributes to diabetes and other debilitating metabolic disorders including hypertension and heart disease.

PI_NAMEs: SEALE, PATRICK  (contact)

PROGRAM_OFFICER_NAME: HAFT, CAROL R

PROJECT_TERMS: activating transcription factor 4;Address;adipocyte differentiation;Adipocytes;Adipose tissue;Affect;Binding Sites;Biological;Biological Assay;Biological Process;Biology;Body Weight;Brown Fat;candidate identification;CCAAT-Enhancer-Binding Protein-beta;Cell Density;Cell Differentiation process;Cell Physiology;cell type;Cells;Chemicals;Chromatin;Collaborations;combat;Complex;Data;Data Set;Detection;Development;Diabetes Mellitus;diet and exercise;Disease;DNA;Enhancers;epigenomics;Exposure to;Fatty acid glycerol esters;fighting;Gene Expression;gene network;gene repression;Generations;Genes;Genetic Screening;Genetic Transcription;genome-wide analysis;Genomics;Glucocorticoid Receptor;Goals;Growth and Development function;Health;Health Benefit;Heart Diseases;Homeostasis;Human;Hyperlipidemia;Hypertension;in vivo;insight;Kinetics;knockout animal;knockout gene;Laboratories;lipid biosynthesis;lipid metabolism;Mass Spectrum Analysis;Mesenchymal Stem Cells;Metabolic Diseases;Metabolism;Modification;Molecular;Multipotent Stem Cells;Mus;Mutation Analysis;Normal tissue morphology;novel;Obesity;Obesity Epidemic;Organ;paralogous gene;Physiological;Play;Population;PPAR gamma;programs;Proteins;Proteome;Proteomics;recruit;response;Risk;Role;Signal Transduction;stem cell fate;subcutaneous;therapeutic target;Tissue-Specific Gene Expression;Tissues;transcription factor;translational potential;United States;Visceral

PROJECT_TITLE: Gene Networks promoting adipocyte cell differentiation and function

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Tau pathology (tauopathy) is a prevailing hallmark of Alzheimer’s disease (AD) and multiple other neurodegenerative diseases. This proposal aims to understand how USP11, multi-functional enzyme known to remove ubiquitin conjugates from proteins, contribute to tauopathy in brain. This proposal will allow us to determine if USP11 enzymatic activity and associated molecular mechanisms represent promising targets to mitigate tau pathogenesis.

PI_NAMEs: KANG, DAVID E (contact);WOO, JUNGA "ALEXA"

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Acetylation;Age;age related;Aging;Alzheimer's Disease;Alzheimer's disease brain;Antibodies;Autophagocytosis;Autopsy;Axonal Transport;Behavioral;Binding;Biochemical;Biological;Biological Assay;Biosensor;Brain;Cells;Complex;Cycloheximide;Defect;Deubiquitination;Electrophysiology (science);Enzymes;experimental study;Family;Female;Fluorescence Resonance Energy Transfer;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Functional disorder;Gene Dosage;Gene Modified;Genetic Models;Human;Human Genome;Image;Impaired cognition;Impairment;In Vitro;in vivo;insight;Link;Lysosomes;male;Mediating;member;Messenger RNA;Modification;Molecular;mouse model;multicatalytic endopeptidase complex;Mus;mutant;Neurodegenerative Disorders;neurofibrillary tangle formation;neuroinflammation;neuron loss;Neurons;neurotoxicity;novel;Outcome;Pathogenesis;Pathology;Pathway interactions;Patients;Peptide Hydrolases;Phenotype;Phosphorylation;Post-Translational Protein Processing;Proteins;Recombinant Proteins;Regulation;Role;sarkosyl;scaffold;Scaffolding Protein;Severities;sex;Sex Differences;Slice;Synapses;Synaptic plasticity;System;tau aggregation;tau function;tau mutation;tau Proteins;tau-1;Tauopathies;Testing;Tissues;Toxic effect;TRAF6 gene;Transgenic Mice;Ubiquitin;ubiquitin isopeptidase;ubiquitin-protein ligase;Ubiquitination;Viral;X Chromosome

PROJECT_TITLE: Deubiquitinase USP11 in tau regulation and age-related tauopathy

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: PROJECT NARRATIVE There is a critical need to identify the cellular and molecular mechanisms underlying cerebrovascular function in both healthy and disease states associated with aging. The studies in this proposal will investigate how the brain endothelial cell enriched enzyme, tissue nonspecific alkaline phosphatase (TNAP), protects against the loss of cerebral function. The results will identify a potential therapeutic target that may be used improve cerebrovascular function and functional recovery in age-related disorders.

PI_NAMEs: BROWN, CANDICE  (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Address;Age;age group;age related;age-related disease;aged;Aging;aging brain;aging population;aging related;Alkaline Phosphatase;artery occlusion;astrogliosis;Behavioral;behavioral outcome;Biology;Blood - brain barrier anatomy;Blood Preservation;Blood Vessels;blood-brain barrier permeabilization;bone;Brain;Brain Diseases;brain endothelial cell;brain health;cadherin 5;Cell Physiology;Cerebral endothelium;Cerebral Ischemia;cerebral ischemic injury;cerebral microvasculature;cerebrovascular;Cerebrovascular Disorders;Cerebrum;conditional knockout;Cre driver;Data;Disease;ecto-nucleotidase;Endothelial Cells;enzyme activity;Enzymes;Exhibits;experimental group;Extravasation;fasudil;Female;Foundations;Functional disorder;Gene Expression;Genetic;Health;Homeostasis;Human;human disease;improved;In Vitro;in vivo;indexing;inhibitor;Injections;injured;Injury;Ischemic Stroke;Knowledge;Label;Link;LoxP-flanked allele;male;Metabolism;middle age;Middle Cerebral Artery Occlusion;Minerals;Modeling;Molecular;mouse model;multiphoton microscopy;Mus;Nervous System Disorder;neurovascular unit;new therapeutic target;normal aging;novel;old mice;Outcome;Pathologic;Pathway Analysis;Pathway interactions;Permeability;pharmacologic;Physiological;post stroke;Prediction of Response to Therapy;preservation;protective pathway;Recovery of Function;Regulation;Reperfusion Therapy;response;restoration;Rho-associated kinase;Role;Signal Pathway;Signal Transduction;Stroke;stroke outcome;Testing;Therapeutic;therapeutic target;Tissues;tool;Tracer;translational impact;Treatment Efficacy

PROJECT_TITLE: The role of tissue nonspecific alkaline phosphatase in brain endothelial cell homeostasis


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Rare Diseases

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECT NARRATIVE Abnormal development of oligodendrocytes contributes to the pathophysiology of a number of neurological diseases and disorders such as amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and glioblastoma, the deadliest of brain cancers. The proposed study utilizes advanced genetic techniques to investigate the mechanism of oligodendrocyte precursor cell development in the brains of mice. Results from these studies may offer new insights into pathological conditions such as demyelination, neuronal degeneration, and CNS cancers, while also providing an entry point to develop therapeutic means to combat these debilitating diseases.

PI_NAMEs: VUE, TOU YIA  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Alleles;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Apical;Area;ASCL1 gene;Astrocytes;Axon;axon guidance;Basic Science;BHLH Protein;Binding Sites;Brain;Cell Adhesion Molecules;cell fate specification;cell motility;Cell Surface Proteins;cell type;Cells;Central Nervous System;ChIP-seq;combat;Complex;conditional knockout;constitutive expression;contactin;Corpus Callosum;Demyelinating Diseases;Demyelinations;design;Development;differential expression;Disease;Dorsal;Electrophysiology (science);Electroporation;Exhibits;experimental study;Fiber;Functional disorder;Generations;Genes;Genetic;Genetic Techniques;Genetic Transcription;Genome;glial cell development;Glioblastoma;gliogenesis;Glioma;Goals;gray matter;Growth Factor;Homing;Immunoprecipitation;insight;learned behavior;Maintenance;Malignant Glioma;Malignant neoplasm of brain;Malignant neoplasm of central nervous system;Malignant Neoplasms;Mediating;Messenger RNA;Modeling;Molecular;mouse model;Multiple Sclerosis;Mus;mutant;Myelin;Myelin Basic Proteins;myelination;neonatal brain;Neoplasm Metastasis;Nerve Degeneration;nerve stem cell;Nervous System Disorder;neurogenesis;Neuroglia;Neurons;novel;oligodendrocyte progenitor;Oligodendroglia;Pathologic;Play;Population;postnatal;precursor cell;Process;progenitor;programs;Proliferating;Property;protein expression;Radial;Regulation;Reporting;response;RiboTag;Role;Schizophrenia;Specific qualifier value;Surface;System;Testing;Tetanus Helper Peptide;Therapeutic;Time;transcription factor;Transcriptional Regulation;transcriptome sequencing;Undifferentiated;Ventricular;white matter

PROJECT_TITLE: Transcriptional control of OPC fate specification and homing to gray matter and white matter in the CNS

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: CHARLESTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative Aberrant expression of PRMT5 is frequently observed in triple negative breast cancer (TNBC). This project will dissect the critical role of TRAF6/PRMT5/ULK1 axis in regulating PRMT5 activation, autophagy induction, and TNBC progression, and determine the synergistic effect of PRMT5 and autophagy inhibitors in TNBC. TNBC cell culture models, xenograft mouse models and de-identified breast cancer patient samples will be used in the proposed studies.

PI_NAMEs: GAN, WENJIAN  (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: American;anti-cancer research;Arginine;Autophagocytosis;Biological Process;Biology;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Patient;breast cancer progression;cancer diagnosis;Cancer Etiology;cancer subtypes;cancer therapy;Cell Culture Techniques;Cell Proliferation;Cessation of life;Clinical Trials;combat;Combined Modality Therapy;Cytoplasm;Cytoprotection;Data;effective therapy;Genetic;improved;inhibition of autophagy;inhibitor;Invaded;Malignant Breast Neoplasm;Mediating;Methylation;migration;Modeling;Molecular;mouse model;mRNA Differential Displays;Neoplasm Metastasis;new therapeutic target;novel;Oncogenic;Organ;pharmacologic;phase II trial;preclinical study;Prognosis;protein activation;protein expression;protein function;Protein-Arginine N-Methyltransferase;Regulation;Resistance;Resources;Role;Sampling;Stress;Survival Rate;targeted agent;Testing;therapeutic target;therapy resistant;TRAF6 gene;triple-negative invasive breast carcinoma;tumor growth;ubiquitin-protein ligase;Ubiquitination;Woman;Xenograft procedure

PROJECT_TITLE: Characterizing and targeting PRMT5 in autophagy for cancer treatment

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: Project Narrative: People with HIV (PWH) are living longer due to effective antiretroviral therapy drugs (ART), but they have higher cardiovascular risk and sudden death, and while the mechanism is not clear, we hypothesize that ART increases cardiovascular risk by inducing cardiac fibrosis, leading to sudden death in PWH. Our proposal focuses on illuminating the mechanism(s) of HIV-ART-mediated organ fibrosis and dysfunction using HIV mouse models. The results from the investigation may provide evidence for novel strategies to prevent or slow organ fibrosis in PWH.

PI_NAMEs: AHAMED, JASIMUDDIN  (contact)

PROGRAM_OFFICER_NAME: KETEMA, FASSIL

PROJECT_TERMS: Acceleration;Acetylcysteine;antifibrotic treatment;Antiplatelet Drugs;antiretroviral therapy;Autopsy;Blood Platelets;cardiovascular disorder risk;cardiovascular risk factor;cell type;Cells;Clinical;Communicable Diseases;comorbidity;coronary fibrosis;Data;Dose;effective intervention;Etiology;Exhibits;Fibrosis;Foundations;Functional disorder;Goals;Heart;Heart failure;HIV;HIV anti-retroviral;Human;improved;In Vitro;in vivo;Individual;inhibitor;Injections;innovation;Intervention;Investigation;Knock-out;Life Expectancy;Link;LoxP-flanked allele;Macrophage;Magnetic Resonance Imaging;Measures;Mediating;Membrane Transport Proteins;Mesenchymal;mouse model;Mus;Myeloid Cells;Myocardial dysfunction;novel strategies;Organ;patient population;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Phenotype;Pilot Projects;Pirfenidone;Plasma;Platelet Activation;Play;Population;potential biomarker;prevent;Prevention strategy;Process;profibrotic cytokine;Protease Inhibitor;Proteins;Publishing;Quality of life;receptor;recruit;Regimen;Research;Risk;Ritonavir;Role;Signal Transduction;Source;Sudden Death;Techniques;Tenofovir;Testing;Transforming Growth Factor beta;Transforming Growth Factors;Transgenic Mice;Transgenic Organisms;translational potential;Xenograft procedure

PROJECT_TITLE: Cardiovascular Risk of Antiretroviral Therapy Drugs in HIV

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Prevention;Substance Misuse

ORG_CITY: LOUISVILLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Alcohol-associated liver disease (ALD) is a spectrum of liver disorders ranging from hepatic steatosis to steatohepatitis with varying degrees of fibrosis and cirrhosis. ALD is a major cause of morbidity, mortality, and health care costs in the US and worldwide. However, there is no FDA-approved therapy for any stage of ALD. The overall goal of this project is to test the therapeutic efficacy of s-EH inhibition at different stages of ALD severity, and to provide a mechanistic foundation for using s-EH inhibition as a novel therapy for alcohol-induced liver pathology.

PI_NAMEs: KIRPICH, IRINA A. (contact)

PROGRAM_OFFICER_NAME: LIN, LI

PROJECT_TERMS: Ablation;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Animal Experiments;Animal Model;Anti-Inflammatory Agents;Attenuated;attenuation;Biological Markers;Blood;Blood specimen;chemokine;Cirrhosis;CXCL1 gene;cytokine;Dietary Supplementation;Disease;Disease Progression;effective therapy;Enzymes;Epoxide hydrolase;Epoxy Compounds;Etiology;Evaluation;FAT gene;Fatty Acids;Fatty Liver;FDA approved;Fibrosis;Foundations;Genetic;Glycols;Goals;Health Care Costs;Heavy Drinking;Hepatic;Hepatitis;Hepatocyte;Human;In Vitro;in vivo;Individual;Infection;Inflammation;Inflammatory;inhibitor;Injury;Kidney;Lipids;Liver;Liver diseases;liver injury;Lung;Macrophage;Mediating;Mediator;Messenger RNA;Metabolic Diseases;Metabolism;monocyte;Morbidity - disease rate;mortality;Mus;N-3 polyunsaturated fatty acid;Names;neutrophil;Neutrophil Infiltration;non-alcoholic fatty liver disease;novel;novel therapeutic intervention;novel therapeutics;Obesity;Organ failure;organ regeneration;Pathogenesis;Pathology;Patients;peripheral blood;pharmacologic;Phenotype;Plasma;Play;PPAR gamma;preservation;prevent;Prevention;Preventive;Production;Property;receptor;Resolution;Role;Severity of illness;Steatohepatitis;systemic inflammatory response;Testing;Therapeutic;therapeutic effectiveness;therapeutic evaluation;therapeutic target;therapeutically effective;tissue regeneration;Transgenic Organisms;Treatment Efficacy;Whole Blood

PROJECT_TITLE: Role of Soluble Epoxide Hydrolase in Alcohol-Associated Liver Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-R(04)]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE Changes in alternative splicing are an important feature of cardiac remodeling and heart failure. This project will employ mass spectrometry and computational methods to decipher how alternative splicing networks rewire cardiac protein composition, structure, and function. The results may provide insights into disease mechanisms by revealing how alternative splicing regulates cardiac gene expression.

PI_NAMEs: LAM, MAGGIE  (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Address;Affect;Aging;Alternative Splicing;Architecture;Area;Biological Assay;Biological Process;biophysical techniques;Biophysics;Cardiac;Complement;Computing Methodologies;Custom;Data;deep learning;detection assay;Development;Disease;Etiology;Exons;experimental study;Failure;Functional disorder;Gene Expression;gene regulatory network;Genes;Genetic;Goals;Guide RNA;Half-Life;Heart;Heart Diseases;Heart failure;Heart Hypertrophy;in vivo;insight;Introns;Knowledge;Large-Scale Sequencing;Mass Spectrum Analysis;Mediating;Metabolic;Methods;Modeling;Molecular;mouse model;multiple omics;Mus;Nonsense-Mediated Decay;Pathologic;Pathway interactions;Pattern;Phenotype;Post-Translational Protein Processing;prediction algorithm;programs;Protein Databases;protein folding;protein function;Protein Isoforms;protein structure;Proteins;Proteome;Proteomics;Quality Control;Regulation;response;RNA Splicing;RNA-Binding Proteins;Role;Solubility;Stable Isotope Labeling;Structure;System;Tissue-Specific Splicing;Tissues;tool;Transcript;transcriptome sequencing;Translating;Variant;Ventricular Remodeling

PROJECT_TITLE: Alternative Protein Isoforms in Ventricular Remodeling

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: NARRATIVE Investigations at cortical layer level in neuroscience not only advance our understanding of the cortical micro-circuitry in vivo in health and disease, but also help bridge the gap between macroscopic (e.g., conventional fMRI, behavior) and microscopic (e.g., extracellular recordings) measures of brain function. In this project, we will develop a whole-brain layer-specific imaging sequence tool in humans, for achieving fMRI at high resolution (£800 µm isotropic), high specificity (not being spatially biased with unspecific vein signals as in BOLD), high sensitivity (robust measurement at layer-level resolution), high spatial accuracy (layer fMRI analysis in native fMRI space to avoid blurring and errors arising from registration), whole brain coverage, and eventually extending layer fMRI to more flexible connectivity- based experiment designs.

PI_NAMEs: CHAI, YUHUI  (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: 3-Dimensional;Address;Adopted;analysis pipeline;Anatomy;Animals;Area;Behavior;Blood;blood perfusion;Blood Volume;Brain;Clinical;clinical development;Code;connectome data;Data;Data Set;data sharing;design;Development;Dimensions;Disease;Experimental Designs;experimental study;extracellular;flexibility;Functional Imaging;Functional Magnetic Resonance Imaging;Goals;Health;high resolution imaging;Hour;Human;human imaging;Image;imaging modality;Imaging Techniques;improved;in vivo;Investigation;Label;Magnetic Resonance Imaging;Maintenance;Maps;Measurement;Measures;meter;Methods;Microscopic;millimeter;movie;Neurosciences;Performance;Physiologic pulse;Play;Preparation;Protons;Research;Resolution;Rest;Role;Sampling;Sensitivity and Specificity;Signal Transduction;Specificity;Techniques;technology development;tool;Training;user-friendly;Veins;Visual;Water

PROJECT_TITLE: Unlocking whole brain, layer-specific functional connectivity with 3D VAPER fMRI

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]