ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: YORK

ORG_NAME: ASSOCIATION OF FOOD AND DRUG OFFICIALS

ORG_STATE: PA

PHR: RFA-FD-22-021 AFDO’s System for Agriculture, Food, Health, E-Inspections and Registration (SAFHER): Project Narrative The Association of Food and Drug Officials’ (AFDO) efforts under this cooperative agreement are intended to support the planning, development, implementation, operation, and maintenance of data management system to be utilized by State, Local, Tribal, and Territorial (SLTT) partners in both human and animal food programs. AFDO will build on an already established user community of stakeholders to enhance FDA’s ORA Data Exchange capabilities by utilizing software development methodologies (i.e. Agile) to ensure a long-term sustainable data management system that is easy to use and maintain by state regulatory partners during and after this cooperative agreement. Through effective governance, vendor procurement, and resource management, this project will deliver a national regulatory data repository that will work towards achieving a national Integrated Food Safety System (IFSS) while promoting One Health and supporting domestic mutual reliance initiatives to protect the food supply and advance public health.

PI_NAMEs: MANDERNACH, STEVEN  (contact)

PROGRAM_OFFICER_NAME: LAC, ANH

PROJECT_TITLE: System for Agriculture, Food, Health, E-inspection, and Registration (SAFHER)


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: CHAPEL HILL

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Calprotectin is a metal binding, innate immune protein that accumulates at extremely high levels at the site of infection. We discovered that calprotectin has enzymatic activity that leads to the inactivation of -lactam antibiotics, including ampicillin, amoxicillin, and oxacillin. Here, we propose to measure how calprotectin mediated antibiotic inactivation affects antibiotic treatment of infected mice, while also elucidating the molecular mechanism of -lactam inactivation.

PI_NAMEs: CONLON, BRIAN PATRICK (contact);KEHL-FIE, THOMAS EVERETT

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Affect;Affinity;Amoxicillin;Ampicillin;Antibiotic Resistance;Antibiotic Therapy;antibiotic tolerance;Antibiotics;Bacteremia;Bacteria;Bacterial Infections;beta-Lactamase;beta-Lactams;Binding;Binding Sites;Biological Assay;Biological Process;Carbapenems;Clinic;Complement;Cytoplasm;Data;Dependence;Development;drug development;enzyme activity;Escherichia coli;extracellular;Failure;Future;Growth;Human;Hydrolysis;Immune;immune activation;improved;in vivo;Infection;inhibitor;innate immune function;Innate Immune Response;innovation;Ions;Kinetics;Lactams;Leukocyte L1 Antigen Complex;Manganese;Measures;Mediating;Meropenem;Metal Binding Site;Metals;Methods;minimal inhibitory concentration;Modeling;Molecular;Monobactams;multidisciplinary;Mus;mutant;neutrophil;Nutrient availability;Outcome;Oxacillin;pathogen;Penicillins;Pharmaceutical Preparations;Pharmacodynamics;Physiological;pressure;Production;Proliferating;Protein Biochemistry;Proteins;Reaction;Research Personnel;response;Salts;Serine;Site;Staphylococcus aureus;Staphylococcus aureus infection;Structure;success;Sulbactam;Systemic infection;Temperature;Testing;Therapeutic;tissue culture;TLR4 gene;Wild Type Mouse;Wound Infection;Zinc

PROJECT_TITLE: Calprotectin and Antibiotic Activities at the Infection Interface

STUDY_SECTION: AIRT

STUDY_SECTION_NAME: Anti-Infective Resistance and Targets Study Section [AIRT]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Human Genome;Precision Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ANN ARBOR

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative: Cardiomyopathies are heart muscle disorders that occur in 1 out of 250 individuals in the general population and are often due to genetic variants that reduce the effective gene “dose” (also referred to as “haploinsufficiency”). However, despite knowledge of the primary genetic causes, prediction of which individuals are at highest risk is currently not possible because additional variants in the genetic code probably “modify” the risk associated with the primary genetic causes. Focusing on genes that are commonly associated with cardiomyopathy, this proposal will find these additional genetic modifiers with the goal that high-risk patients can be more accurately predicted and receive better treatments in the future.

PI_NAMEs: HELMS, ADAM S (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: Affect;Alleles;Allelic Imbalance;autosome;Binding Sites;Biological Assay;Biomechanics;Cardiac;Cardiac Myocytes;Cardiomyopathies;causal variant;Cells;cellular pathology;Clinical;Clinical Data;CRISPR/Cas technology;Data;Disease;Dose;Exhibits;Future;Gene Expression;General Population;Genes;Genetic;Genetic Code;Genetic Diseases;Genetic Transcription;genetic variant;genome sequencing;genome wide association study;genomic variation;Genomics;Goals;high risk;homologous recombination;Human;human induced pluripotent stem cells;Hypertrophic Cardiomyopathy;Impairment;Individual;induced pluripotent stem cell;Knowledge;Left;Linkage Disequilibrium;loss of function;Maps;Messenger RNA;Modeling;mouse model;mRNA Expression;Mus;Muscle function;muscular structure;Mutagenesis;Myocardial dysfunction;Myocardium;Myopathy;Pathway interactions;Patients;Penetrance;personalized medicine;Phenotype;phenotypic data;Population;precision medicine;Probability;Proteins;prototype;Quality Control;Quantitative Trait Loci;Regulatory Element;Reporter;Resolution;Risk;Role;Series;Severities;Single Nucleotide Polymorphism;Structure;Testing;transcription factor;Untranslated RNA;Variant;Ventricular;whole genome;Work

PROJECT_TITLE: Cis regulatory variants of haploinsufficiency genes as cardiomyopathy modifiers

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Prevention;Sarcopenia

ORG_CITY: SALT LAKE CITY

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Sarcopenia represents a highly prevalent, unresolved medical issue in an increasing aging and sedentary population. A pharmacologic therapy for muscle loss does not exist, and current diet/exercise therapeutic approaches are often ineffective and/or unfeasible. Findings from these studies may lead to novel approaches for the treatment of skeletal muscle atrophy.

PI_NAMEs: DRUMMOND, MICAH J;FUNAI, KATSUHIKO  (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Acceleration;Acyltransferase;Affect;Age;Aging;aging population;Aldehydes;ATG3 gene;Atrophic;Autophagocytosis;Autophagosome;Carboxy-Lyases;Cardiovascular Diseases;Cell Death Induction;cell injury;Cell Size;cell type;Clinical;Collection;Data;Diameter;diet and exercise;Enzymes;experimental study;glutathione peroxidase;healthy aging;Hydroxyl Radical;In Vitro;in vivo;inhibition of autophagy;Knowledge;Lecithin;Lipid Peroxides;Lipids;Lysophosphatidylcholines;Lysosomes;Maintenance;Medical;Membrane;Metabolic Diseases;Mitochondria;Mobility decline;Modeling;Molecular;Mus;muscle aging;Muscle Cells;Muscle Fibers;muscle form;Muscle function;muscle strength;Muscle Weakness;Muscular Atrophy;Nature;novel strategies;old mice;overexpression;Oxidative Stress;Pathway interactions;pharmacologic;Phosphatidylethanolamine;Phosphatidylserines;Phospholipids;pi bond;Play;Polyunsaturated Fatty Acids;Population;prevent;Production;Protein Biosynthesis;protein degradation;Proteolysis;Quality of life;Reaction;Reactive Oxygen Species;Role;sarcopenia;sedentary;Signal Transduction;Skeletal Muscle;skeletal muscle wasting;Source;Stress;Testing;Therapeutic;Water

PROJECT_TITLE: LOOH-induced muscle atrophy with age

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Palliative Care;Prevention;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE: We propose to address a pressing need to improve quality of life of older adults with advanced cancer by studying how their social networks provide needed instrumental and emotional support and guidance that, in turn, facilitate frank conversations about their illness, advance care planning and engagement with palliative care. While prior studies have examined the structure of social networks (i.e., family, friends, clergy, internet contacts, cancer survivors), ours will be the first to assess how networks function to provide support, and the qualities of interpersonal relationships within the network that facilitate (or impede) behaviors linked to improved quality of life at the end of life. We will use innovative quantitative, qualitative and mixed methods to analyze surveys and network maps of 300 older patients with advanced cancer and in-depth interviews with a diverse subset of 70 patients and their social network members to characterize potentially malleable aspects of structure, function, and quality of relationships that can inform future social network interventions.

PI_NAMEs: EPSTEIN, RONALD M.;MOHILE, SUPRIYA G. (contact);YOUSEFI NOORAIE, REZA

PROGRAM_OFFICER_NAME: GREEN, PAIGE A

PROJECT_TERMS: Address;Advance Care Planning;Advanced Malignant Neoplasm;Affect;aging related;anti-cancer treatment;Behavior;behavior change;Cancer Survivor;cancer therapy;Caring;Characteristics;chemotherapy;Clergy;clinically significant;Data;density;Disease;Education;Emotional;end of life;Evolution;Family;Friends;Future;Gender;Goals;Health behavior;health literacy;human old age (65+);improved;improved outcome;Individual;Influentials;innovation;Internet;Interpersonal Relations;Interview;Life Expectancy;Link;Maps;member;Methods;Misinformation;Morals;older adult;older patient;Palliative Care;Pathway Analysis;Pathway interactions;patient subsets;Patients;Perception;preference;Process;promote resilience;Quality of life;randomized trial;Research;resilience;response;rurality;Sampling;social;social determinants;Social Network;social network intervention;social relationships;social structure;Social support;stressor;Structure;Surveys;therapy development;Treatment-related toxicity;tumor progression;Typology;United States National Institutes of Health;Work

PROJECT_TITLE: Pathways to Resilience of Social Networks of Older Adults with Advanced Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-L (A1)]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Firearms Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Primary Health Care;Social Determinants of Health;Violence Research

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Secure firearm storage programs are an evidence-based approach to mitigate firearm injury and mortality among all young people in the United States and they are low-cost, scalable, and non-politically divisive. S.A.F.E. Firearm is an evidence-based primary prevention program to promote secure storage of firearms that has been implemented in pediatric primary care within two large health systems in Colorado and Michigan, and there is now an opportunity to implement S.A.F.E. Firearm in community settings, including federally qualified health centers (FQHCs) and look-alike safety net health centers where 1 in 11 Americans currently receive health care. The proposed project will be conducted in collaboration with AllianceChicago and the Illinois Primary Health Care Association and will: (a) systematically adapt the S.A.F.E. Firearm program and implementation approach for FQHCs in collaboration with clinicians, health center leaders, parents, and community members; (b) test the effectiveness and identify mechanisms of the adapted program and implementation strategies for supporting equitable delivery of S.A.F.E. Firearm in Illinois FQHCs; and (c) provide insights for equitable implementation of secure firearm storage programs in lower-resourced settings that can be taken to scale nationally to save lives.

PI_NAMEs: BEIDAS, RINAD SARY (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Accident and Emergency department;acute care;Age;Ambulatory Care;American;analog;Area;Automobiles;Behavior;Cause of Death;Cessation of life;Characteristics;Chicago;Childhood;Clinic;clinical decision support;Collaborations;Colorado;Communities;community setting;Consolidated Framework for Implementation Research;cost;Counseling;COVID-19;COVID-19 pandemic;Effectiveness;effectiveness outcome;effectiveness testing;effectiveness-implementation RCT;effectiveness/implementation hybrid;Electronic Health Record;Eligibility Determination;Environment;Equity;Ethnic Origin;evidence base;Evidence based practice;Evidence based program;experience;Federally Qualified Health Center;firearm storage;Firearms;Future;future implementation;Gun injury;Harm Reduction;Health;Health Resources;Health system;Healthcare;Hybrids;Illinois;implementation outcomes;implementation science;implementation strategy;implementation study;Inequity;Injury;insight;Intervention;Interview;Knowledge;Life;member;Methods;Michigan;minority communities;Minority Groups;mortality;Parents;Participant;Patients;Persons;Population;practice-based research network;Preparation;pressure;Prevention program;Primary Care;Primary Health Care;Primary Prevention;Problem Solving;programs;Race;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Reporting;Resource-limited setting;Safety;safety net;Seat Belts;Secure;Services;social health determinants;Strategic Planning;stressor;suicidal morbidity;System;Testing;Training;United States;Visit;Well Child Visits;wellness visit

PROJECT_TITLE: Implementing A Secure Firearm Storage Program in Illinois Health Centers in Partnership with AllianceChicago and the Illinois Primary Health Care Association

STUDY_SECTION_NAME: Special Emphasis Panel[ZNR1 REV-N (04)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Machine Learning and Artificial Intelligence;Women's Health Research

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project Narrative Breast conserving surgery is used as part of the treatment of breast cancer, the leading cancer among women in the US, in which the lumpectomy specimen containing breast cancer is excised with a minimum rim of normal tissue. If the breast cancer close to the specimen edge, referred to as the positive margin, is missed during the surgery, it can lead to a high rate of re-surgery. We develop an X-ray dual-energy cone-beam microCT technology for point-care, intraoperative positive-margin identification, allowing for reduction of re- surgery rate in breast conserving surgery and for tumor cataloguing in breast cancer research and treatment.

PI_NAMEs: PAN, XIAOCHUAN  (contact);SIDKY, EMIL Y

PROGRAM_OFFICER_NAME: WU, YICONG

PROJECT_TERMS: 3-Dimensional;Address;Adipose tissue;Adoption;advanced breast cancer;Algorithms;anti-cancer research;attenuation;Breast;Breast Cancer Treatment;breast imaging;breast lumpectomy;Breast-Conserving Surgery;cancer therapy;Cataloging;Catalogs;Characteristics;Clinical;clinical application;Clip;Cone;cost;Data;Data Analyses;Databases;Dedications;deep learning;design;Development;Duct (organ) structure;Evaluation;Excision;Histologic;Image;Image Analysis;Image Enhancement;image reconstruction;Image-Guided Surgery;imaging properties;Imaging Techniques;improved;innovation;Learning;Lobular Carcinoma;Machine Learning;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mastectomy;meetings;Metals;Methods;microCT;Morphologic artifacts;Morphology;Nature;Normal tissue morphology;Operative Surgical Procedures;Outcome;Patient imaging;Patients;quantitative imaging;radiological imaging;radiologist;Research;Research Personnel;Residual state;Roentgen Rays;Sampling;Scanning;Source;Specimen;Speed;success;Surgeon;System;Techniques;Technology;Testing;Time;Tissues;tomosynthesis;tumor;Tumor Tissue;virtual;Woman;X-Ray Computed Tomography;X-Ray Medical Imaging

PROJECT_TITLE: Intraoperative quantitative CT imaging of breast specimen for reducing re-surgery rate and tumor cataloguing

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: HG

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: SANTA CRUZ

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

ORG_STATE: CA

PHR: PROJECT NARRATIVE This grant proposal aims to develop novel computational methods and software tools for analyzing pangenomic data. The proposal is divided into five specific aims, which include creating a pangenome mapper supporting long-reads, developing personalized pangenomes, creating a pangenome variant calling and imputation method for unified genome inference, genotyping complex SVs involving protein-coding genes, and developing mature rGFA based variant calling for reporting both SV and small variants within polymorphic sequence. The proposed software tools and methods will enable researchers to analyze pangenomic data more effectively and efficiently, leading to new insights into genetic variation and its role in disease and other biological processes.

PI_NAMEs: LI, HENG ;MARSCHALL, TOBIAS ;PATEN, BENEDICT  (contact)

PROGRAM_OFFICER_NAME: DAYAL, JYOTI

PROJECT_TITLE: Tools for comprehensive variant characterization using the pangenome

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-M (M2)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Postmortem studies show that there is normative loss of synaptic connections in the prefrontal cortex into adulthood believed to support cognitive development but which has also been implicated in mental illness, which often emerges in adolescence. However, evidence from live humans has not been possible until the recent progress in MRI, including those we have proposed in the original grant. Here, we add gold-standard PET based measures in adults of the original study in order to confirm the characterization of the non-invasive MRI measures of the original study and electroencephalography (EEG) to understand the effects of synapse loss on brain function.

PI_NAMEs: LUNA, BEATRIZ  (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Addendum;Adolescence;Adolescent;Adult;Affect;age related;age related changes;Animals;Attention deficit hyperactivity disorder;autism spectrum disorder;Automobile Driving;Autopsy;Binding;Bipolar Disorder;Brain;Childhood;Clinical;Cognitive;cognitive ability;cognitive control;cognitive development;cohort;Coupled;critical period;Data;density;Development;Diffusion Magnetic Resonance Imaging;Discipline;Electroencephalography;Electrophysiology (science);Equilibrium;Excitatory Synapse;experience;Funding;Glutamates;Glycoproteins;Grant;Human;improved;in vivo;indexing;insight;Link;Longitudinal cohort;Magnetic Resonance Imaging;magnetic resonance imaging/electroencephalography;Measurement;Measures;Mediating;Mental disorders;Mental Health;Methodology;Modeling;Mood Disorders;MRI Scans;neural;neural circuit;Neurites;Neurocognitive;neurodevelopment;Neurodevelopmental Disorder;neuroimaging;neuroimaging marker;neuromechanism;Neuronal Plasticity;Neurons;neurophysiology;Neurophysiology - biologic function;neurotransmission;Noise;novel;Outcome;parent grant;Parents;Participant;Patient Recruitments;Periodicals;phosphodiester;Population;Positron-Emission Tomography;Prefrontal Cortex;Process;Process Assessment;Property;Psychopathology;recruit;Recurrence;Research;Research Personnel;Risk;Running;Schizophrenia;Shapes;signal processing;Signal Transduction;Specificity;spectroscopic imaging;Substance Use Disorder;Support System;Synapses;synaptic pruning;Synaptic Vesicles;Testing;Time;tool;Tracer;transition to adulthood;Trees;Universities;uptake;Validation;validation studies;Work

PROJECT_TITLE: Effects of adolescent synaptic pruning on cortical signal processing

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Obesity

ORG_CITY: IRVINE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative  Endocrine interactions have been demonstrated as causal and contributory to most common, most notably obesity, type 2 diabetes and resulting cardiovascular complications. The goal of this proposal is to closely bridge computational and experimental methods to systematically dissect mechanisms by which tissues communicate and how these interactions are perturbed in disease settings. Collectively, we will begin with newly developed and unbiased computational approaches which survey population data, validate using high-throughput in vitro assays and evaluate therapeutic potential of new endocrine interactions using mouse models of metabolic disease.

PI_NAMEs: SELDIN, MARCUS MICHAEL (contact)

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: Address;Bayesian Network;Bioinformatics;bioinformatics pipeline;Cardiovascular system;cell type;Communication;Complex;computerized tools;Data;Disease;disease model;Dissection;Endocrine;Gene Expression;Genetic Variation;Goals;guided inquiry;high throughput screening;Human;in silico;in vitro Assay;in vivo;Individual;insight;Link;Machine Learning;Metabolic Diseases;Metabolism;Methods;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Organ;Organism;parent grant;Pathway interactions;Plasma;Population;population survey;Proteins;Proteomics;Resources;Series;Signal Transduction;Signaling Molecule;success;Surveys;Therapeutic;Tissues;tool;Training;Validation;Variant;Visualization;Work

PROJECT_TITLE: Integrative approaches to dissection of endocrine communication


NIH_SPENDING_CATS: Cardiovascular;Complementary and Integrative Health;Dietary Supplements;Heart Disease;Nutrition

ORG_CITY: NEW HAVEN

ORG_DEPT: PHARMACOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative: The neutrophil is the most abundant white blood cells and plays critical roles in inflammatory diseases including various heart diseases. Polyunsaturated fatty acids (PUFAs), which include omega-3 fatty acids and are enriched in foods such as fish oil, are known to have beneficial effects on heart health, but how they protect hearts is not well understood. This study will shed lights into how PUFAs help to reduce inflammation pertinent to heart health.

PI_NAMEs: WU, DIANQING  (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Acids;Acute;Address;Adult;Affect;Amino Acid Sequence;Animals;beta catenin;Binding;Binding Proteins;Biological;Biology;Cardiac health;Cell surface;Cell Surface Receptors;Cells;deprivation;Diet;Disease;Eicosapentaenoic Acid;Embryo;Embryonic Development;Epidemiology;Essential Fatty Acids;extracellular;Extracellular Domain;fatty acid transport;Fatty Acids;Fish Oils;follow-up;Food;glucose metabolism;Health;Heart;Heart Diseases;Heart Injuries;Homeostasis;Human;Immune response;Infection;Inflammation;Inflammatory;insight;Knockout Mice;Knowledge;Leukocytes;lipid metabolism;lipidomics;Low-Density Lipoproteins;Lysosomes;Mediating;metabolomics;microbial;Modeling;multiple omics;Mus;Myocardial Reperfusion Injury;neutrophil;Neutrophil Activation;novel;Oleic Acids;Omega-3 Fatty Acids;pathogen;Pathway interactions;Phenotype;Play;Polyunsaturated Fatty Acids;Process;Proteins;Proteomics;Publishing;recruit;Regulation;Reporting;Role;Signal Transduction;Site;Specificity;Testing;Tissues;transcriptomics;tumorigenesis;uptake;Wnt proteins;WNT Signaling Pathway

PROJECT_TITLE: A novel mechanism for polyunsaturated fatty acid uptake and action in neutrophils

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Kidney Disease;Lupus;Precision Medicine

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: There is a clear need for identifying easily measurable biomarkers for diagnosing and monitoring disease  progression in systemic lupus erythematosus, predicting response to therapy and prognosticating long term  outcome in this chronic systemic autoimmune disease. In this study, we will perform extended clinical validation  of selected biomarker proteins in multiple patient cohorts in order to define the potential clinical utility of these  test proteins. The availability of accurate biomarkers to gauge each phase of the disease can significantly  improve patient outcome in lupus.

PI_NAMEs: MOHAN, CHANDRA  (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: Address;Affect;Age;aggressive therapy;Arthritis;Autoimmune;Autoimmune Diseases;Biological Assay;Biological Markers;biomarker identification;biomarker selection;Biopsy;Body Fluids;Body System;Cerebrospinal Fluid Proteins;Chronic;Clinical;clinical predictors;Clinical Treatment;Clinical Trials;cohort;Connective Tissue;Connective Tissue Diseases;Decision Making;Dermatitis;Diagnosis;Diagnostic;diagnostic biomarker;Disease;Disease Progression;Disease remission;Early treatment;Enzyme-Linked Immunosorbent Assay;Ethnic Origin;Excretory function;Exhibits;Flare;follow-up;Follow-Up Studies;Functional disorder;Funding;Goals;Histologic;improved;indexing;Kidney;Kidney Diseases;Longitudinal cohort;Lupus;Measurable;Monitor;Morbidity - disease rate;multi-ethnic;Neoadjuvant Therapy;Nephritis;Neurologic;Neuropsychiatric Systemic Lupus Erythematosus;novel;novel therapeutics;Organ;Outcome;Pathology;Patient Selection;Patient-Focused Outcomes;Patients;Performance;Pharmaceutical Preparations;pharmacodynamic biomarker;Pharmacodynamics;Phase;Prediction of Response to Therapy;predictive marker;Prevalence;Prognostic Marker;prognostication;protein biomarkers;Proteins;Proteomics;Reporting;Research;response;response biomarker;Rheumatism;Sampling;Sampling Biases;Serum;sex;systemic autoimmune disease;Systemic disease;Systemic Lupus Erythematosus;Testing;tissue injury;Tissues;tool;Training;treatment response;Urine;Validation;Visit

PROJECT_TITLE: Monitoring Disease in Lupus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-W (04)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CORAL GABLES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE In this study, we will determine differences in neighborhood social and built environment (SBE) exposures over the life course among Hispanic individuals born in and outside the US, will evaluate whether associations between neighborhood SBE and cognitive and MRI outcomes differ by place of birth, and will conduct semi- structured interviews to develop a richer understanding of neighborhood SBEs at various life stages among foreign-born and US-born Hispanic individuals. Limited data are presently available on how neighborhood SBE differ based on place of birth and how they relate to the healthy immigrant effect and impact late life brain health among US Hispanic immigrants. This study targets these scientific gaps to elucidate social/structural causes of Hispanic disparities in ADRD risk that may be targeted via community-level interventions.

PI_NAMEs: BESSER, LILAH  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: access restrictions;Acculturation;Address;Affect;Age;Aging;Alzheimer's disease related dementia;Area;Birth Place;brain health;BRAIN initiative;brain volume;built environment;Centers for Disease Control and Prevention (U.S.);Childhood;Cognition;Cognitive;cognitive change;cognitive function;cohort;Collaborations;community intervention;Complement;Data;Data Collection;Dementia;dementia risk;density;deprivation;Device or Instrument Development;disorder risk;Disparity;Education;Employment;Ensure;Environment;Episodic memory;ethnic disparity;Ethnic Origin;Ethnic Population;ethnic segregation;experience;Florida;Funding;Future;Geographic Information Systems;Goals;Grant;Green space;Health;Health behavior;Health Benefit;health disparity;Health Promotion;Healthcare;Hippocampus;Hispanic;Hispanic Populations;Imagery;Immigrant;improved;indexing;Individual;insight;interest;Interview;late life;Learning;Life;Life Cycle Stages;Link;Longitudinal cohort study;Magnetic Resonance Imaging;Maps;Measures;Mental health promotion;middle age;mild cognitive impairment;Minority Groups;multidisciplinary;Neighborhoods;Not Hispanic or Latino;novel;older adult;Outcome;Participant;Persons;Phenotype;Physical activity;Pilot Projects;Population;Population Intervention;Publishing;Qualitative Methods;Questionnaires;Race;racial disparity;racial population;Recording of previous events;Reporting;Research;Residencies;resilience;Resources;Sampling;segregation;Site;social;social capital;social cohesion;social determinants;social engagement;Social Environment;social health determinants;Societal Factors;Socioeconomic Status;socioeconomics;Structure;success;Testing;Time;Translating;Variant;White Matter Hyperintensity;Work;young adult

PROJECT_TITLE: Associations between neighborhood environments across the life course and Alzheimer's disease and related dementia outcomes among Hispanic older adults born in and outside the US

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-9 (M1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;HIV/AIDS;Infectious Diseases;Machine Learning and Artificial Intelligence;Mental Health;Microbiome;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Cognitive and mood disorders occur more commonly in people with HIV than in the general population but the field still does not fully understand why and has no effective therapies for most of those who are affected. This project will take a new approach to understanding how cognition, mood, substance use, and medical characteristics cluster together and will identify new biological mechanisms associated with these conditions. The successful project could lead to new diagnostic tests and therapies for these disorders, which would have substantial public health relevance.

PI_NAMEs: ELLIS, RONALD J.;LETENDRE, SCOTT L (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;AIDS dementia;antiretroviral therapy;Biological;Biological Assay;Biological Markers;Biology;biopsychosocial;Blood;Brain imaging;Categories;Central Nervous System;Central Nervous System Diseases;Cerebrospinal Fluid;Characteristics;Classification;Clinical;Cognition;Cognition Disorders;Cognitive;Cognitive deficits;Cohort Studies;comorbidity;daily functioning;Data;Diagnosis;Diagnostic tests;Disease;disease classification;effective therapy;Encephalitis;Frequencies;Funding;General Population;Genetic;genome wide association study;Goals;Gut associated lymphoid tissue;gut dysbiosis;Heterogeneity;high dimensionality;HIV;HIV anti-retroviral;HIV-associated neurocognitive disorder;Image;Individual;Inflammation;Injury;innovation;Intervention;Investments;Life;Machine Learning;machine learning method;magnetic resonance spectroscopic imaging;Mediating;Medical;metabolome;Methods;microbial;microbiome;microbiome analysis;Mood Disorders;Moods;multidimensional data;neuroAIDS;neurobehavioral;Neurocognitive Deficit;neurocognitive disorder;Neuropsychological Tests;novel;novel diagnostics;novel strategies;novel therapeutics;Participant;Pathogenesis;Pathology;Performance;Persons;Pharmaceutical Preparations;Phenotype;Production;progression risk;Proteins;public health relevance;Research;Research Priority;Risk Factors;RNA;sex;Sex Differences;Site;Specimen;Standardization;substance use;supervised learning;United States National Institutes of Health;unsupervised learning;Work

PROJECT_TITLE: Biopsychosocial Phenotypes and Potential Mechanisms in CHARTER

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pediatric;Sleep Research;Social Determinants of Health;Substance Misuse

ORG_CITY: NORFOLK

ORG_NAME: OLD DOMINION UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative Early life social isolation and loneliness produce deleterious effects on socioemotional and cognitive development and can increase drug and alcohol usage in adolescent humans and animals. We will assemble a multidisciplinary team with expertise in translational SUD research/addiction, neurocognitive testing, neural signal processing, sleep neurobiology, neurohistology and circadian rhythms to determine how SI and loneliness impact drug seeking and consummatory behavior, cognition and neurocircuit activity and the role that sleep may play in altered cognition and addictive behavior. Our goal is to identify, and develop methods to pursue, promising lines of research that will increase understanding of the effects of early life SI and loneliness on subsequent cognition and addictive behavior.

PI_NAMEs: BRITTEN, RICHARD ANTONY;GUO, MINGLEI ;SANFORD, LARRY D (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: addiction;Addictive Behavior;Adolescence;Adolescent;Adult;Adverse effects;Animals;Astrocytes;Behavior;Brain;Brain region;Chronic;Circadian Rhythms;Cocaine;Cognition;cognitive development;cognitive performance;cognitive testing;Consummatory Behavior;Data;Decision Making;Development;Drug usage;Electroencephalography;Emotional;experimental study;Female;Goals;Health;Hearing;Housing;Human;Inflammasome;Life;Loneliness;Maintenance;male;marenostrin;Mediator;Methamphetamine;Methods;Microglia;Modeling;Morphology;multidisciplinary;Mus;neural;Neurobiology;Neurocognitive;neurocognitive test;Neuroimmune;neuroinflammation;neurotransmission;Outcome;Pharmaceutical Preparations;Play;polycarbonate;prevent;Procedures;Proteins;Public Health;Rat Strains;Rattus;regional difference;Relapse;Research;response;Risk;Role;Self Administration;sex;Sex Differences;signal processing;Sleep;Sleep disturbances;Smell Perception;Social Conditions;Social isolation;Stress;Substance Use Disorder;Testing;underage drinking;Visual;Weaning;young adult

PROJECT_TITLE: Effects of social isolation and loneliness during early life on neurocognitive development and addiction

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 CEM-N (M1)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Dietary Supplements;Microbiome;Natural Products;Neurodegenerative;Nutrition;Physical Activity;Prevention

ORG_CITY: RALEIGH

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: Project Narrative Our goal is to validate an age-appropriate and achievable lifestyle modification to proactively protect cognitive health in an aging population. We hypothesize that the cognitive benefits boosted by dietary flavonoids (e.g. from berries) and by physical exertion (movement) are both mediated by the diversity, functionality and composition of gut microbiota, which control delivery of cognition-relevant phenolic metabolites into human circulation. This project will explore the dynamic interplay between physical activity-driven, microbe-mediated flavonoid biotransformation into bioactive phenolic metabolites, and age-related cognitive function.

PI_NAMEs: CHEATHAM, CAROL L;LILA, MARY ANN ANN (contact);NIEMAN, DAVID CHRISTOPHER

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: absorption;Acceleration;active lifestyle;Aerobic;Aerobic Exercise;Age;age related;age related cognitive change;age related decline;Aging;aging brain;aging demography;aging population;Alzheimer's Disease;American;Animal Testing;Animals;Anti-Inflammatory Agents;Antibiotics;Attenuated;Berry;Biological Markers;Blueberries;Circulation;Clinical;Clinical Trials;Cocoa Powder;Cognition;Cognitive;cognitive benefits;cognitive change;cognitive enhancement;cognitive function;cognitive performance;colon microbiota;Complex;Dementia;Dependence;Diet;Diet Modification;Dietary Flavonoid;disability;Economic Burden;Environment;Exercise;Exertion;Exhibits;experience;experimental study;family burden;fecal transplantation;Flavonoids;Food;Genetic;Goals;good diet;gut microbiome;gut microbiota;gut-brain axis;Health;healthspan;Hepatic;High Fat Diet;Human;human old age (65+);immunoregulation;Impaired cognition;improved;in vivo;Individual;Inflammation;Ingestion;Intake;Intervention;Libraries;Life Expectancy;Life Style Modification;Link;Lower Gastrointestinal Tract;Mediating;Metabolic;Metabolic Biotransformation;Metagenomics;Microbe;microbiome;microbiome alteration;microbiota profiles;Modeling;Moderate Exercise;mouse model;Movement;Mus;neuroinflammation;older adult;Older Population;Outcome;Participant;Physical activity;Plasma;Population;prebiotics;prevent;primary outcome;Research;Resources;Risk;Role;Running;secondary outcome;Shotguns;Societies;stool sample;Supplementation;synergism;Tea;transmission process;uptake;Walking;Work

PROJECT_TITLE: Age-related Cognitive Changes: Effects of Combined Flavonoid Intake and Physical Exertion Mediated by the Gut Microbiome

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Infectious Diseases;Radiation Oncology;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE The standard of care treatment for locally advanced cervical cancer is the same for all patients and results in cure only 30-60% of the time. Those who die of the disease are most often young, otherwise healthy women who lose many productive years of life. The overarching goal of this proposal is to improve survival for women with cervical cancer through the first test of a new and shorter treatment paradigm in a clinical trial, and by testing new drug and radiation combinations using a novel animal model of cervical cancer in a manner that will ultimately allow patient-specific selection of treatment approaches in the future.

PI_NAMEs: CONTRERAS, JESSIKA ;MARKOVINA, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: VIKRAM, BHADRASAIN

PROJECT_TERMS: Acceleration;Affect;Animal Model;antagonist;anti-tumor immune response;Antigens;Antitumor Response;barrier to care;Bioinformatics;Biological Markers;biomarker driven;Blood;Brachytherapy;candidate marker;candidate validation;Cells;Cervix Carcinoma;Cervix Neoplasms;Cessation of life;checkpoint inhibition;checkpoint therapy;chemokine;chemoradiation;chemotherapy;Chemotherapy and/or radiation;chronic infection;circulating biomarkers;Cisplatin;Clinic;Clinical Trials;Clinical Trials Design;Collection;Combination immunotherapy;Combined Modality Therapy;Cytotoxic T-Lymphocytes;Data;design;Disease;Distant;Dose;draining lymph node;Effectiveness;Engineering;Exclusion;External Beam Radiation Therapy;Failure;falls;Flow Cytometry;fluorodeoxyglucose positron emission tomography;Future;Goals;Grant;Harvest;Head and Neck Cancer;Heterogeneity;high risk;Human Papillomavirus;Immune;Immune response;Immune system;Immunocompetent;Immunohistochemistry;Immunologic Stimulation;Immunotherapy;improved;In Vitro;in vivo;Infiltration;Inflammatory;inflammatory milieu;inhibitor;Life;Link;Malignant neoplasm of cervix uteri;Metastatic/Recurrent;Modeling;mouse model;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Neoplasm Metastasis;neutrophil;novel;novel strategies;novel therapeutics;patient population;patient stratification;Patients;Pelvic lymph node group;Pelvis;permissiveness;Pharmaceutical Preparations;Phase I/II Clinical Trial;Phase I/II Trial;Platinum;pre-clinical;Pre-Clinical Model;Primary Neoplasm;Productivity;programmed cell death protein 1;Radiation;radiation resistance;randomized trial;recruit;Recurrence;Regimen;Regulatory T-Lymphocyte;Resistance;response;response biomarker;Safety;safety testing;secondary endpoint;Selection for Treatments;Signal Transduction;Specimen;Spleen;Squamous cell carcinoma;standard of care;success;synergism;System;T cell receptor repertoire sequencing;T-Lymphocyte;Testing;therapy resistant;Time;Toxic effect;translational study;treatment response;tumor;Tumor Immunity;Tumor-associated macrophages;tumor-immune system interactions;United States;Woman

PROJECT_TITLE: Accelerated Brachytherapy Forward Chemoradiation Therapy (ABC-RT) for Cervical Cancer

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Physical Activity;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_CITY: PROVIDENCE

ORG_NAME: MIRIAM HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE Individuals with overweight and obesity can experience substantial health benefits from behavioral weight loss treatment, but there are barriers to in-person programs and remote programs are rarely reimbursed by third- party payers. As decisions for insurance coverage for obesity treatment continue to evolve, it is important that reimbursement considerations for remote programs are evidence based and that patients are referred to the type of remote program that is most likely to benefit them. This study represents a critical first step towards informing those decisions, by comparing remote weight loss programs which vary in delivery format and level of support, and seeking to develop algorithms to predict for whom each treatment should be recommended.

PI_NAMEs: UNICK, JESSICA L (contact)

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: Accountability;Adherence;Adult;African American population;Aftercare;Age;algorithm development;Algorithms;Behavioral;Black race;Body mass index;Body Weight decreased;Characteristics;Communication Methods;comorbidity;Computerized Medical Record;cost;cost effective;cost effectiveness;Data;design;Diet;diet and exercise;Diet Monitoring;Education;Educational Status;Effectiveness;Electronic Health Record;Elements;Employment Status;Enrollment;Ethnic Origin;Evidence based program;Exercise;experience;Feedback;Fostering;Frequencies;Geography;Goals;Health Benefit;health care settings;health literacy;Hispanic;Hour;Household;Human;improved;Income;Individual;Individual Differences;Insurance Coverage;Intervention;intervention effect;Kilogram;Latino Population;Learning;male;Measures;Medical;Modeling;Monitor;Motivation;Nonverbal Communication;Obesity;obesity treatment;online intervention;Overweight;Participant;Patient Self-Report;Patients;personalized medicine;Persons;Physical activity;preference;Problem Solving;Procedures;program dissemination;programs;Psychosocial Factor;psychosocial outcome;Public Health;Race;Randomized;randomized trial;Recommendation;recruit;remote delivery;remote intervention;remote therapy;Sample Size;Sampling;Self Efficacy;sex;Socioeconomic Status;success;telephone coaching;Testing;Third-Party Payer;Time;Touch sensation;Travel;treatment response;trial comparing;videoconference;Videoconferencing;virtual delivery;Weight;weight loss intervention;weight loss program;Work

PROJECT_TITLE: Comparison of behaviorally-based remote approaches to optimize weight loss and identification of factors which characterize treatment response

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-W (02)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Palliative Care;Skin Cancer

ORG_CITY: DURHAM

ORG_DEPT: SURGERY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE: Improving the quality of care for older adults with melanoma is public health priority because 1) it affects a large and growing number of people, 2) it can reduce ineffective or unwanted care, 3) it can maximize goal- concordant effective care. This project aims to address these priorities by improving the quality of evidence and adapting a shared decision-making framework designed to improve communication between providers and patients. Given trends in the incidence of melanoma in older adults, the proposed work in this study could impact approximately 40,000 older Americans annually who develop melanoma.

PI_NAMEs: LEE, JAY SOONG-JIN (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Adjuvant Therapy;Affect;Aging;American;Benefits and Risks;Biology;BRAF gene;cancer clinical trial;Caregivers;Caring;chemotherapy;Clinical Trials;Communication;Communication Tools;Data;Databases;Decision Making;design;Disease;Educational process of instructing;Effectiveness;Elderly;end of life;evidence base;experience;Face;Feedback;Focus Groups;Goals;Guidelines;Health;Health Personnel;Healthcare;high risk;human old age (65+);Immune checkpoint inhibitor;improved;Incidence;ineffective therapies;Intervention;Link;Lymph Node Dissections;Malignant neoplasm of lung;Malignant Neoplasms;Medical Oncologist;Medicare;MEKs;Melanoma;Modification;Observational Study;older adult;Oncology;operation;Operative Surgical Procedures;Outcome;Patient Outcomes Assessments;Patient Preferences;Patients;Pattern;personalized medicine;Persons;Pilot Projects;Positioning Attribute;preference;Provider;public health priorities;Quality of Care;Quality of life;Recommendation;Reporting;Research;Research Project Grants;routine practice;SEER Program;Sentinel Lymph Node Biopsy;shared decision making;Surgeon;Surveys;targeted treatment;tool;Treatment outcome;trend;Variant;Work;young adult

PROJECT_TITLE: Improving decision-making for older adults with melanoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-R (M1)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE Fifty percent of all blindness is due to retinal degenerative diseases, which are a group of conditions caused by damage to light sensing neurons of the eye. We have identified a cell type in the retina, called microglia, that protects the retina from damage associated with these diseases. This project is aimed at understanding the protective mechanisms, which in turn will help to identify new potential targets for treatment of these disease.

PI_NAMEs: SABAN, DANIEL RAPHAEL (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Acute;Address;Affect;age related;Age related macular degeneration;Aging;Alzheimer's Disease;Amyloidosis;Anti-Inflammatory Agents;Autopsy;Biology;Blindness;Cell Adhesion Molecules;cell type;Cells;Cessation of life;Clinical Management;Computer Analysis;conditional knockout;Data Analyses;Data Set;Defect;Development;Disease;Disease Progression;Drug or chemical Tissue Distribution;Elements;Environment;experience;experimental study;Eye;Fringe Benefit;Funding;Galectin 3;Gene Expression Profile;Genetic;genetic approach;Glucose;Glycolysis;Homeostasis;Human;Inflammation Mediators;Inherited;Injury;Knock-out;Knockout Mice;Knowledge;laser capture microdissection;Lecithin;Ligands;Light;lipidomics;Lipids;Macrophage;Maps;mass spectrometric imaging;Mediating;Medical;Metabolic;Metabolism;Microglia;migration;Modeling;molecular dynamics;monocyte;mouse model;Multiple Sclerosis;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neurons;novel;Outcome;Oxidative Stress;Paralysed;Pathology;Pathway interactions;Patients;Pattern;Penetration;Phagocytosis;Phenotype;photoreceptor degeneration;Photoreceptors;Poison;Population;Positioning Attribute;prenatal;preservation;Process;programs;protein biomarkers;receptor;recruit;Recycling;resilience;Resolution;Resources;response;Retina;retinal damage;Retinal Degeneration;Retinal Detachment;Retinal Pigments;Role;Series;Shapes;Signal Transduction;single-cell RNA sequencing;SLC2A1 gene;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Structure of retinal pigment epithelium;Technology;Testing;Tissues;Toxin;transcriptome;transcriptome sequencing;transcriptomics;treatment strategy;TREM2 gene;Vision;Work

PROJECT_TITLE: Cellular and Molecular Dynamics of Retinal Microglial in the Context of Photoreceptor Degeneration

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Prevention;Rare Diseases;Substance Misuse;Tuberculosis

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative Unhealthy alcohol use among people with HIV (PWH) can interrupt engagement in HIV care, adherence to antiretroviral therapy, and viral suppression. As a result, alcohol use is a barrier to HIV elimination. We are testing whether an intervention that focuses on alcohol reduction integrated into HIV care in Pune, India can clinical outcomes and overall health.

PI_NAMEs: CHANDER, GEETANJALI ;GUPTA, AMITA  (contact)

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: Adherence;Administrative Supplement;Adoption;alcohol abuse therapy;Alcohol consumption;alcohol misuse;alcohol screening;alcohol use disorder;Alcohols;antiretroviral therapy;Behavioral;binge drinking;Biological Markers;Caring;Clinic;Clinical;co-infection;Cognitive;compare effectiveness;cost;Counseling;Country;Databases;disability-adjusted life years;Disease Progression;drinking;Effectiveness;effectiveness evaluation;effectiveness outcome;effectiveness/implementation study;Epidemic;Ethanol;Evidence based intervention;Evidence based treatment;Exclusion;Funding;Government;Health;Health system;Heavy Drinking;HIV;HIV anti-retroviral;HIV Infections;HIV/TB;Hybrids;implementation framework;implementation outcomes;improved outcome;inclusion criteria;incremental cost;incremental cost-effectiveness;India;Individual;Infrastructure;Interruption;Intervention;intervention delivery;Maintenance;Measures;medical schools;medication compliance;Methods;modifiable risk;Monitor;Morbidity - disease rate;mortality;motivational enhancement therapy;neglect;Outcome;Outcome Measure;pandemic disease;Patient Self-Report;Patients;Persons;Policies;Procedures;Professional counselor;Provider;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Resources;Risk;Risk Factors;RNA;screening;standard care;standard of care;success;System;Testing;therapy adherence;Training;transmission process;treatment as prevention;Treatment outcome;Tuberculosis;Viral

PROJECT_TITLE: Hybrid trial for Alcohol reduction among people with TB and HIV in India (HATHI)


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Depression;Drug Abuse (NIDA only);Mental Health;Mental Illness;Pediatric;Serious Mental Illness;Substance Misuse;Suicide

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Cannabis use during adolescence co-occurs with depression and suicidal ideation at greater than expected rates. However, little is known about the impact of acute cannabis use and withdrawal on depression and suicidal ideation, particularly among high-risk adolescents. This study seeks to disentangle the time-varying relationships between acute cannabis use and withdrawal on proximal depression and suicide risk using ecological momentary assessment within the context of a randomized controlled design in order to guide the development of scalable and individualized interventions aimed to reduce depression and suicide risk among adolescents.

PI_NAMEs: SCHUSTER, RANDI MELISSA (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: Abstinence;Acute;Address;Adolescence;Adolescent;Adolescent marijuana use;adolescent suicide;Age;Alcohols;Cannabinoids;Cannabis;cannabis withdrawal;Cellular Phone;child depression;clinical decision-making;clinically relevant;comorbidity;contingency management;Data;Data Collection;depressive symptoms;Development;Distal;Ecological momentary assessment;Event;Feeling suicidal;high risk;high-risk adolescents;Hour;improved;Incentives;Individual;Intervention;Intoxication;Knowledge;Legal;Major Depressive Disorder;marijuana legalization;marijuana use;Measures;Mental Depression;Mental disorders;Methods;Monitor;Moods;Motivation;negative mood;Negative Reinforcements;Nicotine;Participant;Patient Self-Report;Pattern;Pharmaceutical Preparations;Phase;pilot test;prolonged abstinence;prospective;Prospective Studies;Protocols documentation;Psychopathology;Randomized;randomized controlled design;Recording of previous events;Recovery;recruit;Reporting;Residual state;Resolution;Risk;Sampling;Schools;Severities;Social Environment;substance use;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Testing;Therapeutic Effect;Time;twelfth grade;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Characterizing Proximal Risk for Depressive Symptoms and Suicidal Ideation with Acute Cannabis Use and Withdrawal Among Adolescents Using Ecological Momentary Assessment

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: PROJECT NARRATIVE The Health Equity Research Hub at the University of Maryland Baltimore (UMB) will provide localized technical assistance and scientific support for assigned CHESIs in addition to partnership support, research capacity-building, and training. Our vision and proposed activities align with modeling and teaching our authentic community-academic partnership (CAP) approach in addition to providing technical and scientific support. Our overarching goal is to not only serve as a catalyst for CHESIs to complete their ComPASS projects in a rigorously scientific manner but to achieve their goals in a manner that demonstrates how communities of patients and researchers can collaborate to address social determinants of health (SDOH) and advance health equity in neighborhoods and society at large.

PI_NAMEs: MULLINS, C. DANIEL  (contact)

PROGRAM_OFFICER_NAME: MOMIN, BEHNOOSH RAMJI

PROJECT_TERMS: Academia;Academy;Acceleration;Address;Award;Baltimore;Baptist Church;Caring;catalyst;clinical practice;Clinical Research;Clinical Sciences;Collaborations;Collection;Common Data Element;Communication;Communities;community academic partnership;community engaged research;community engagement;Community of Practice;community organizations;community partnership;community research;Community-Led Health Equity Structural Intervention;Data;data management;Data Science;Democracy;Development;disorder prevention;disparity reduction;Dissemination and Implementation;Educational process of instructing;Ensure;Equity;equity, diversity, and inclusion;Ethnic Population;Evaluation;experience;Fostering;Funding;Funding Agency;Goals;Health;Health Disparities Research;health disparity;health equity;Health equity research;Health Policy;Health Professional;Health Promotion;Health Sciences;Healthcare;Human Resources;Infrastructure;innovation;insight;Institution;Intervention;Intervention Studies;Lead;Leadership;Learning;Lebanon;lens;Maryland;meetings;member;Methodology;Modeling;Monitor;multidisciplinary;Neighborhoods;Output;Patients;Phase;Play;Population;professor;programs;Protocols documentation;Public Health;Qualifying;racial minority population;Reduce health disparities;Reporting;Research;Research Activity;Research Design;Research Ethics;Research Infrastructure;Research Methodology;Research Personnel;Resources;Role;Science;science and society;skills;social health determinants;Societies;Technical Expertise;Training;Translational Research;Trust;trustworthiness;Underserved Population;United States;United States National Institutes of Health;Universities;uptake;Vision;Voice;Workforce Development

PROJECT_TITLE: ComPASS Health Equity Research Hub at UMB

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-P (52)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Nutrition;Prevention;Social Determinants of Health

ORG_DEPT: NUTRITION

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE The world population is growing older yet living to age 90 is still considered to be exceptional. In this project, we will assess whether modifiable factors in older adults impact their likelihood of living to age 90. The project will generate critical evidence targeted towards older adults on the role of modifiable factors on longevity to promote health span and to re-orient medical practice to focusing on holistic prevention efforts.

PI_NAMEs: SMITH-WARNER, STEPHANIE A (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Accounting;Address;Adherence;Adult;Age;aged;Aging;Alcohol consumption;Alcohols;Behavioral;Birth;Body mass index;Cardiovascular Diseases;Cessation of life;Chronic Disease;Classification;Coffee;cohort;comorbidity;comorbidity Index;Complement;DASH diet;Data;data repository;Diabetes Mellitus;Diet;diet and cancer;dietary;Dietary Factors;Dietary Fiber;disability;Disease;disorder prevention;disorder risk;Education;Enrollment;Europe;Evaluation;Exposure to;follow-up;Food;food consumption;Genetic Determinism;Geographic Locations;Glean;Goals;Health;health related quality of life;healthspan;healthy aging;Healthy Eating;healthy lifestyle;Human;human old age (65+);improved;indexing;Individual;insight;Intake;Life Expectancy;life span;Life Style;lifestyle factors;Longevity;Measures;Meat;Medical;Mediterranean Diet;men;modifiable risk;mortality;multiple chronic conditions;North America;novel;older adult;Older Population;Outcome;Participant;Physical activity;Physical Function;Physiological;Play;Population;population based;premature;Prevention;primary outcome;Process;Processed Meats;prospective;Prospective cohort;Prospective Studies;Recommendation;Recording of previous events;Risk Factors;Role;sex;Smoking History;Smoking Status;social;social factors;Social support;sociodemographic variables;sociodemographics;synergism;trend;Update;Woman

PROJECT_TITLE: LIFEstyle factors and LONGevity (LIFELONG) Study

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Neurosciences;Substance Misuse

ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative Binge alcohol consumption poses a major public health burden in the U.S., leading to increased rates of mortality and other pathophysiologies, such as anxiety and depression. The proposed work will examine how repeated cycles of binge-like alcohol drinking dysregulate serotonin signaling in a discrete neural circuit, which may drive future binge alcohol intake and contribute to negative health outcomes. This may lead to the identification of more effective therapeutic strategies for the treatment of alcohol use disorder.

PI_NAMEs: PINA, MELANIE M (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Alcohol consumption;alcohol reward;alcohol use disorder;Alcohols;Amygdaloid structure;anatomical tracing;Anxiety;Award;Behavioral;binge drinking;Cell Nucleus;Communication;Complex;Confocal Microscopy;Death Rate;Doctor of Philosophy;dorsal raphe nucleus;Education;Efferent Pathways;Foundations;Functional disorder;Future;Genetic;Goals;Health;Heavy Drinking;Immunohistochemistry;Individual;Maps;Mental Depression;Mentors;Mentorship;neural circuit;neural patterning;Neurosciences;neurotransmission;Operative Surgical Procedures;Oral;Outcome;parent grant;Pathway interactions;programs;Public Health;Publications;Research;Risk;Role;Serotonergic System;Serotonin;Signal Transduction;skills;Solid;symposium;System;Techniques;therapeutically effective;Training;treatment strategy;Work;Writing

PROJECT_TITLE: Alcohol-Induced Alterations in Orbitofrontal Cortex Serotonin Signaling

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: ALBANY

ORG_DEPT: BIOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

PHR: Project Narrative The proposed research addresses a relevant public health issue, as proper development of the neurons that secrete Gonadotropin-releasing hormone (GnRH-1) is essential for sexual development and function throughout life. In this project, we will elucidate molecular mechanisms controlling the development of olfactory support cells and the formation of the terminal nerve, processes essential for supporting the migration of GnRH-1-expressing neurons from the nasal area to the brain, a key event in establishing hormonal regulation. The proposed research is relevant to the mission of NICDH/NIH and will provide essential information needed for diagnosing and treating hypogonadotropic hypogonadism in humans.

PI_NAMEs: FORNI, PAOLO E (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Ablation;Address;Adult;Affect;Afferent Neurons;Area;Axon;Bioinformatics;Brain;cell type;Cells;Cephalic;Classification;Cleavage Under Targets and Release Using Nuclease;Clinic;Clinical;cohort;Cranial Nerves;Data;Defect;design;Development;Developmental Process;Diagnosis;diagnostic criteria;Disease;Dose;Embryo;Embryonic Development;Event;Fertility;Gene Expression;Gene Targeting;Genes;Genetic;Genetic Transcription;GLI3 gene;GNRH1 gene;Goals;Gonadal Steroid Hormones;Gonadotropin Hormone Releasing Hormone;Health;Heterozygote;hormone deficiency;hormone regulation;Human;Hypothalamic structure;Idiopathic Hypogonadotropic Hypogonadism;Image;Immunoprecipitation;improved;Infertility;innovation;Kallmann Syndrome;Klinefelter's Syndrome;Knockout Mice;Life;Ligands;Link;loss of function;loss of function mutation;Mammals;migration;Mission;Molecular;mouse genetics;mouse model;Mouse Strains;Mus;mutant;Nerve;Neural Crest;Neuregulin 1;neurogenesis;Neuroglia;neuron development;Neurons;Nose;novel;novel diagnostics;novel therapeutics;null mutation;olfactory bulb;Olfactory Pathways;olfactory sensory neurons;Pathologic;Patients;Peripheral;personalized medicine;Phenotype;Pituitary Gland;Pituitary Gonadotropins;Presynaptic Terminals;prevent;Process;programs;Puberty;Public Health;receptor;Reporting;reproductive;reproductive development;Research;residence;Role;Schwann Cells;screening;Sex Functioning;Sexual Development;Signal Transduction;single-cell RNA sequencing;Smell Perception;Solid;Supporting Cell;Syndrome;System;Testing;Therapeutic;transcription factor;transcriptome;transcriptomics;United States National Institutes of Health;Vertebrates;Work

PROJECT_TITLE: Understanding the role of the transcription factor Gli3 in Kallmann syndrome and normosmic forms of idiopathic hypogonadotropic hypogonadism

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Screening and Brief Intervention for Substance Misuse;Substance Misuse;Underage Drinking

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: BROWN UNIVERSITY

PHR: Project Narrative This research will support the development of a fully immersive Virtual Reality (VR) experience that can be used in interventions inspired by motivational interviewing to help develop a personal and vivid sense of discrepancy between users’ desired behavior and current levels of drinking. The proposed research will first develop the VR experience through several cycles of user-centered design research with hazardous drinking, young adult users (Phase 1), and then pilot test whether young adults who received a VR-enhanced brief motivational intervention (BMI) drink less and experience fewer alcohol-related problems over six months than those receiving a standard BMI (Phase 2). We will also explore clinic-level barriers to VR implementation among directors of college and community addiction counseling clinics (Phase 3).

PI_NAMEs: WRAY, TYLER BLAKE (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: addiction;Address;Adult;Age;age group;Alcohol abuse;Alcohol consumption;alcohol related problem;Alcohols;Anxiety Disorders;Back;Behavior;behavior change;Behavioral;binge drinking;brief intervention;brief motivational intervention;Cessation of life;Client;Clinic;Cognitive;Collaborations;college;college drinking;commercialization;Communities;community setting;Conflict (Psychology);Consolidated Framework for Implementation Research;Consumption;Counseling;Cues;Data;design;Development;drinking;effective intervention;efficacy testing;Empathy;Exercise;experience;Foundations;Future;Goals;hazardous drinking;Heavy Drinking;heavy drinking young adult;implementation barriers;implementation facilitators;improved outcome;Injury;innovation;interest;Intervention;Interview;Investments;Life;Mental Depression;Mental Health;Meta-Analysis;Methods;Motivation;motivational enhancement therapy;Nature;novel;Outcome;Participant;Pattern;Perception;Phase;pilot test;pilot trial;Population;post intervention;premature;Process;Professional counselor;Program Development;programs;prototype;public health priorities;Randomized;Randomized, Controlled Trials;reduced alcohol use;Reporting;Research;Research Design;Research Methodology;Resistance;Risk Factors;Smoking;Substance abuse problem;substance use;success;Surveys;Techniques;Testing;tool;treatment center;United States;university student;user centered design;virtual reality;virtual reality environment;Work;young adult

PROJECT_TITLE: Using Virtual Reality to help develop discrepancy and elicit change talk in brief motivational interventions for heavy drinking young adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 DD (05)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Drug Abuse (NIDA only);HIV/AIDS;Harm Reduction for Substance Misuse;Health Services;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Opioid Misuse and Addiction;Opioids;Prevention;Primary Health Care;Social Determinants of Health;Substance Misuse;Telehealth

PHR: PROJECT NARRATIVE Tele-Harm Reduction seeks to engage people who inject drugs (PWID) into HIV care by bringing healthcare out of the traditional healthcare system and leveraging syringe services programs as trusted venues to deliver telehealth-enhanced access to antiretrovirals, medications for opioid use disorder, and hepatitis C cure. We urgently need a robust evidence base to prove that Tele-Harm Reduction can help us End the HIV Epidemic in PWID and save lives. We seek to set the foundation to build a new standard of care to treat HIV among PWID.

PI_NAMEs: TOOKES, HANSEL EMORY (contact)

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;addiction;Address;Administrative Supplement;AIDS prevention;Anti-Retroviral Agents;care delivery;care outcomes;Caring;Case Management;Climacteric;combat;Communicable Diseases;Communities;County;Developed Countries;Diagnosis;Disease Outbreaks;Drug user;efficacy study;efficacy testing;efficacy trial;Enrollment;Ensure;Environment;Epidemic;evidence base;experience;Federally Qualified Health Center;flexibility;Florida;Foundations;Goals;Harm Reduction;harm reduction programs;Health;health care delivery;Healthcare;Healthcare Systems;Hepatitis C;Hepatitis C Therapy;Hepatitis C virus;HIV;HIV Infections;HIV Seropositivity;Incidence;Injecting drug user;injection drug use;Intervention;marginalization;medication for opioid use disorder;meetings;Modeling;Needle-Exchange Programs;novel strategies;opioid use disorder;Outcome;patient navigation;Patients;Persons;Play;Population;prevent;Provider;Randomized;recruit;Research;response;Role;service programs;Site;standard of care;Stigmatization;Substance Use Disorder;syndemic;System;telehealth;Trust

PROJECT_TITLE: Recruitment for the efficacy trial of Tele-Harm Reduction in a federally qualified health center operated syringe services program


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Physical Activity;Physical Rehabilitation;Rehabilitation;Social Determinants of Health

ORG_CITY: IOWA CITY

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Voice disorders are common in older adults and can have significant impacts on social interaction. This proposal investigates the impact of voice impairment in older adults on social interaction, loneliness, social disconnectedness, and depression. A series of questionnaires, voice assessments, and interviews will be performed to improve our understanding of how voice disorders affect older adults and how treatment of voice impairment with voice therapy may improve quality of life.

PI_NAMEs: HOFFMAN, MATTHEW R (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Acoustics;Address;Adherence;Adverse effects;Adverse event;Affect;Age;age related changes;Aging;Alabama;Anatomy;Assessment tool;Caring;Characteristics;Clinical;cognitive testing;Collaborations;Communication;Communities;design;Deterioration;Development;Dysphonia;Effectiveness;Emotional;Environment;Event;Exercise;Exercise Therapy;Exhibits;experience;Focus Groups;Gerontology;Health;Hearing;human old age (65+);Impaired cognition;Impairment;impression;improved;Injections;innovation;interest;Intervention;Interview;Iowa;Knowledge;Language;Larynx;life span;Loneliness;Measures;Mental Depression;Methods;Moods;Muscular Atrophy;older adult;Older Population;Outcome;Outcome Measure;Participant;Pathologist;Patient Outcomes Assessments;Patients;Personal Satisfaction;Persons;Phonation;Photography;Physiological;Population;primary outcome;programs;Published Comment;Qualitative Research;Quality of life;Questionnaires;Reporting;Research;resistance exercise;Respiratory physiology;Respiratory System;response;Risk;Scientist;Series;sex;Site;social;Social Functioning;Social Interaction;Social isolation;Social outcome;Speech;Speech Pathology;Structure;Techniques;Thyroarytenoid Muscle;Time;United States;Universities;vocal cord;vocalization;Voice;Voice Disorders;voice therapy;Withdrawal;Work

PROJECT_TITLE: Characterizing the impact of presbyphonia on social interaction


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Mental Health;Neurodegenerative;Neurosciences;Patient Safety;Prevention

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE PUBLIC HEALTH RELEVANCE STATEMENT: Post Operative Delirium (POD) is notorious for its association with poor outcomes including post-operative cognitive decline (POCD) and high mortality, and exposes elderly patients to a greater risk of developing Alzheimer’s disease, and Alzheimer’s disease patients are more likely to develop POD. The discovery of epigenetics biomarkers whereby those at high risk for POD can be identified would lead to optimized patient care, improved patient outcomes, and more efficient allocation of hospital resources. As such, the proposed research investigating the role of epigenetics in POD and POCD is expected to provide important and new information that can be used to help guide the prevention of POD, POCD, and dementia and is likely to facilitate the development of treatments for elderly patients who experience POD.

PI_NAMEs: SHINOZAKI, GEN  (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Age;aged;Aging;aging process;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Area;BDNF gene;Biological Markers;biomarker identification;Blood;Blood specimen;Brain;brain tissue;cell type;Cognitive deficits;cohort;cytokine;Cytokine Gene;Dangerousness;Data;Data Set;Delirium;Dementia;Development;Diagnosis;Disease;DNA biosynthesis;DNA Methylation;Early Diagnosis;Early identification;Elderly;Environmental Risk Factor;epigenetic marker;Epigenetic Process;experience;Functional disorder;Gene Expression;Genome;genome-wide;Goals;Guide prevention;high risk;Hip Fractures;Hospitals;Human;human study;Impaired cognition;improved;improved outcome;Individual;Inflammation;Inflammatory;Inflammatory Response Pathway;Knowledge;Lead;Length of Stay;life span;Literature;long term memory;Medical;Methods;Microglia;Modification;Molecular;monocyte;mortality;mouse model;neurotrophic factor;old mice;older patient;Operative Surgical Procedures;Outcome;Pathogenesis;Pathologic;Patient Care;Patient-Focused Outcomes;Patients;Peripheral Blood Mononuclear Cell;Play;Population;postoperative delirium;Postoperative Period;potential biomarker;predictive marker;Predisposition;Prevention;Production;prospective;public health relevance;Publishing;Reporting;Research;Resources;response;Risk;Risk Factors;risk prediction;Role;Sampling;Signal Transduction;Testing;therapy development;TNF gene;tool;Whole Blood

PROJECT_TITLE: Epigenetics Biomarker of Post Operative Delirium and Long Term Cognitive Decline among Elderly Dementia Patients

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE There exists a pressing and unaddressed medical necessity to formulate efficacious therapeutic approaches for high-grade serous ovarian cancer and triple-negative breast cancer. Our research endeavors will encompass comprehensive mechanistic investigations and preclinical assessments of PRMT-targeted therapies for the treatment of these diseases. The outcomes of our proposed studies have the potential to furnish a compelling justification for the utilization of protein arginine methyltransferase inhibitors in oncology.

PI_NAMEs: ZHANG, LIN  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: addiction;American Society of Clinical Oncology;Animals;anti-tumor immune response;Arginine;Bromodomains and extra-terminal domain inhibitor;cancer cell;cancer genome;cancer genomics;Cells;Characteristics;Clinic;Clinical;clinical application;clinical development;Clinical Trials;Combined Modality Therapy;Communication;Defect;design;Development;Disease;DNA Damage;DNA Repair;Dose;Drug Combinations;Drug Screening;early phase clinical trial;efficacy evaluation;Enzymes;Epigenetic Process;Exhibits;Functional disorder;Gene Expression;Genes;Genetic Transcription;Genome;genomic profiling;Genomics;homologous recombination;homologous recombination deficiency;Immune response;Immunocompetent;immunoreactivity;Impairment;inhibitor;innate immune pathways;insight;Investigation;Maintenance Therapy;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Medical;Metastatic/Recurrent;Methylation;Minority;Molecular;mouse model;mutant;Mutate;Nature;neoplastic cell;novel;novel strategies;Oncogenes;Oncology;Outcome;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Phase Ib/II Trial;Poly(ADP-ribose) Polymerase Inhibitor;Post-Translational Protein Processing;pre-clinical assessment;Pre-Clinical Model;preclinical evaluation;preclinical study;Prognosis;Proliferating;Protein Inhibition;Protein-Arginine N-Methyltransferase;Proteins;Proteome;Reporting;Repression;Research;research clinical testing;Research Personnel;Resources;RNA Splicing;screening;Serous;success;Systems Biology;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapeutic target;therapeutically effective;translational medicine;Translational Research;treatment response;triple-negative invasive breast carcinoma;tumor;tumorigenesis;Woman

PROJECT_TITLE: Protein arginine methyltransferase inhibitors in treatment of high-grade serous ovarian cancer and triple-negative breast cancer

STUDY_SECTION: MCTC

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics C Study Section [MCTC]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Prevention;Substance Misuse;Substance Misuse Prevention;Violence Research

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The proposed training program “Alcohol Prevention Research on Violence, Equity, and Novel Techniques (A- PREVENT)” T32 Training Program will equip a diverse cohort of new alcohol prevention researchers with the methodological acumen capable of transformative advances in health equity, and formulating solutions that are both pragmatic and pioneering in addressing health disparities. Supported by 20 faculty mentors across 2 departments, the A-PREVENT T32 Training Program will provide advanced research training in alcohol and violence prevention with a focus on: 1) health equity; 2) designing and implementing multi-level interventions; 3) innovative methodological and statistical approaches to assess efficacy across multiple levels of the social- ecological model and 4) learning to critically apply principles of the ethical and responsible conduct of research. This innovative training program will not only diversify the biomedical research workforce with our trainees from diverse backgrounds, but also prepare them to develop and evaluate multi-level preventive interventions that address health disparities in alcohol and violence.

PI_NAMEs: GILMORE, AMANDA KATHERINE (contact);SALAZAR, LAURA F

PROGRAM_OFFICER_NAME: CASTLE, I-JEN

PROJECT_TERMS: alcohol prevention;Equity;novel;Prevention Research;Training Programs;Training Technics;Violence

PROJECT_TITLE: Alcohol Prevention Research on Violence, Equity, and Novel Techniques (A-PREVENT) Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-N (51)]


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Certified Registered Nurse Anesthetists (CRNAs) are the sole anesthesia providers in 80% of rural counties in the United States. However, CRNA burnout is as high as 72%, yielding an increased intention to leave one’s primary position. This will be the first research project to examine organizational factors impacting CRNA burnout and turnover and to identify interventions aimed at sustaining the supply of high-quality surgical and anesthesia care providers in rural populations.

PI_NAMEs: CONGDON, CHRISTINA  (contact)

PROGRAM_OFFICER_NAME: CHANLONGBUTRA, AMORNRAT

PROJECT_TITLE: Anesthesia Care Delivery in Rural America: The Impact of Organizational Climate on Burnout, Job Satisfaction, and Intention to Leave among Certified Registered Nurse Anesthetists

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dietary Supplements;Genetics;Pediatric;Rare Diseases

ORG_CITY: WASHINGTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Public Health Relevance. Combined D/L-2-HydroxyGlutaric Aciduria (D/L-2HGA) is considered a rare yet very severe systemic disease that leads to death within the first months of life and for which there is no therapy. Our data identify novel pathways and mechanisms involved in this disease that enlighten nodes of therapeutic attack for the treatment of this devastating disorder.

PI_NAMEs: AVANTAGGIATI, MARIA L (contact)

PROGRAM_OFFICER_NAME: SHARMA, KARLIE ROXANNE

PROJECT_TERMS: Acids;Advocate;Affect;Alleles;Animals;antagonist;Biochemical;Body Fluids;Cells;Cessation of life;Chromosome 22;Chromosome Mapping;citrate carrier;Citrates;Clinical;Compensation;Craniofacial Abnormalities;Cytosol;Data;Dependence;Development;developmental disease;dietary;DiGeorge Syndrome;Disease;Embryo;Embryonic Development;empowerment;enantiomer;Event;Exhibits;experimental study;Fibroblasts;Future;Genes;Heterozygote;Human;human disease;human model;improved;In Vitro;Inflammation;Inflammatory Response;insight;Life;Link;lipid biosynthesis;Lipids;loss of function;Mediating;Metabolic;metabolomics;microdeletion;Missense Mutation;Mission;Mitochondria;Modeling;Molecular;mouse model;Mus;Mutation;neonatal encephalopathy;neurotoxic;Normal Cell;Normal tissue morphology;novel;novel therapeutic intervention;Outcome;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;patient prognosis;Patients;Phenotype;Pilot Projects;premature;Production;public health relevance;Rare Diseases;Reporting;Respiratory Insufficiency;Seizures;senescence;Source;Structure-Activity Relationship;Supplementation;Symptoms;Syndrome;Systemic disease;Testing;Therapeutic;Time;transcriptomic profiling;transcriptomics;Ventilator;Work

PROJECT_TITLE: A novel murine model of 2-Hydroxyglutaric aciduria

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 RD-8 (01)]


NIH_SPENDING_CATS: Prevention;Social Determinants of Health

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative The UC Berkeley Training Health Equity ScholaRs in InnoVation, PrEvention, and Social Impact (UCB-THRIVES) T32 Fellowship Program aims to equip emerging health equity scholars with the structural competency and methodological expertise essential for developing and evaluating multi-level, preventive interventions to address health inequities in collaboration with marginalized communities. The program will welcome 3 pre-doctoral students each year who receive comprehensive didactic training and immerse research experiences in health equity, multi-level preventive interventions, and rigorous methodological and statistical approaches. In addition to these foundational areas, three crucial cross-cutting themes will underpin the UCB- THRIVES T32 Program and be pivotal in driving sustainable progress in health equity: 1) community engagement, 2) anti-racism, and 3) social impact.

PI_NAMEs: FERNALD, LIA C. H.;MUJAHID, MAHASIN S (contact)

PROGRAM_OFFICER_NAME: KHAN, SHAHNAZ

PROJECT_TERMS: Fellowship Program;health equity;health training;innovation;Prevention;Social Impacts

PROJECT_TITLE: Training Health Equity ScholaRs in InnoVation, PrEvention, and Social Impact (THRIVES) Fellowship Program


NIH_SPENDING_CATS: Aging;Bioengineering;Eye Disease and Disorders of Vision;Lymphatic Research;Neurodegenerative;Neurosciences

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Project Narrative The elevated eye pressure in glaucoma is a result of increased resistance to the outflow of the aqueous humor into the lumen of Schlemm’s Canal. The extent of outflow resistance is associated with the cytoskeletal mediated stiffness of Schlemm’s Canal endothelial cells as these cells have to substantially deform to create the openings required to drain aqueous humor into the canal. I will determine how a major cytoskeletal system in these cells, namely vimentin intermediate filament cytoskeleton, contributes to the mechanics required to form the necessary openings, and thus generation of outflow resistance.

PI_NAMEs: VAHABIKASHI, AMIR  (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Adrenal Cortex Hormones;Affect;Apical;Aqueous Humor;Atomic Force Microscopy;Biochemistry;Biomechanics;career;Cells;Characteristics;Cytoskeletal Filaments;Cytoskeleton;density;Disease;Effectiveness;Endothelial Cells;Endothelium;ex vivo perfusion;Extracellular Matrix;Eye;Eye Enucleation;feasibility testing;Generations;Glaucoma;Homeostasis;Human;In Situ;In Vitro;interest;Intermediate Filaments;knock-down;Knockout Mice;Life Cycle Stages;Measures;mechanical properties;Mechanics;Mediating;Methods;Microfabrication;Microscopy;mouse model;Mus;normotensive;novel;novel therapeutic intervention;Ocular Hypertension;Pathway interactions;Perfusion;Physiologic Intraocular Pressure;Play;pressure;Property;Regulation;Resistance;response;Role;Structure of sinus venosus of sclera;superresolution imaging;Technology;Testing;Therapeutic;therapeutic target;Trabecular meshwork structure;Traction Force Microscopy;Vacuole;Vimentin;Western Blotting

PROJECT_TITLE: The Role of Vimentin Cytoskeleton in the Mechanobiology of Schlemm's Canal Endothelium.


ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative Epidemiological studies clearly show that advanced age is the most important risk factor for cardiovascular disease, but we have an incomplete understanding of how aging promotes cardiovascular disease progression. The accumulation of somatic DNA mutations over time has recently been demonstrated to be a hallmark of aging in many human cell types. The overarching goal of this proposal is to define the extent of somatic mutations in aging human cardiomyocytes, provide an understanding of the mutational processes acting on aging human cardiomyocytes, and explore the link between somatic mutational burden and cardiovascular pathologies, for developing new strategies to treat millions of adults with heart disease associated with aging.

PI_NAMEs: CHOUDHURY, SANGITA  (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: Adopted;Adult;age related;Aging;Algorithms;Alleles;Autopsy;Brain;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular Pathology;cardiovascular risk factor;Cell Nucleus;cell type;Cells;Data;Development;Disease;Disease Progression;DNA Sequence Alteration;DNA sequencing;Dropout;Elderly;Environmental Risk Factor;epidemiology study;Freezing;Genome;genome analysis;Genomic DNA;Genomics;genotoxicity;Goals;hallmarks of aging;Heart;heart disease prevention;Heart Diseases;Heart failure;Human;human old age (65+);In Vitro;innovation;insight;Interphase Cell;Knowledge;Link;Malignant Neoplasms;Methods;Modeling;Mutation;Myocardial dysfunction;Myocardium;Neurons;normal aging;novel;Organ;Oxidative Stress Induction;Phenotype;Ploidies;postmitotic;Premature aging syndrome;pro-aging;Process;Radiation;radiation during childhood;radiation effect;Radiation therapy;Research;Resolution;Role;Series;Single Nucleotide Polymorphism;Somatic Mutation;Techniques;Time;Troponin T;whole genome

PROJECT_TITLE: Single cell, whole genome analysis of the aging human cardiomyocyte Diversity Supplement

STUDY_SECTION: MIM

STUDY_SECTION_NAME: Myocardial Ischemia and Metabolism Study Section[MIM]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PHR: PROJECT NARRATIVE This project will develop a suite of statistical and computational methods for genomics that are robust and efﬁcient. This research will enable inference under complex population genetic models, and help biomedical researchers integrate information from various types of genomic data to reveal fundamental biological processes, thereby broadly facilitating efforts to understand the genetic basis of human biology and disease risk.

PI_NAMEs: SONG, YUN S (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: analytical tool;Area;Attention;Basic Science;Big Data;Biological;Biological Assay;Biological Process;Biology;Biomedical Research;Catalogs;Cells;Collaborations;Communities;Complex;computer scientist;computerized tools;Computing Methodologies;Data;Data Analyses;Development;disorder risk;epigenetic variation;Gene Expression Profiling;Genetic;Genetic Models;Genetic Transcription;Genetic Variation;genomic data;Genomics;Goals;Human Biology;human disease;Immunology;mathematical analysis;mathematical model;Metagenomics;Methods;Modeling;mRNA Translation;novel;Population;Population Genetics;Population Heterogeneity;programs;Research;Research Personnel;sound;Statistical Methods;structural biology;Technology;tool;Transcription Process;Translation Process;Translations

PROJECT_TITLE: Robust and efficient statistical inference methods for genomics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative The proposed research is relevant to public health and the mission of the NIH and NCI because it will test and define a novel targetable mechanism to overcome resistance and enhance responses to immune checkpoint inhibitors in melanoma. Thus, these studies will provide the basis for the development of unique combinatorial approaches to treat patients suffering from melanoma and possibly other cancers.

PI_NAMEs: NORA VAZ SALEIRO, DIANA  (contact)

PROGRAM_OFFICER_NAME: HARRIS, RAYMOND D

PROJECT_TERMS: Affect;anti-PD-1;Antibody Therapy;Autophagocytosis;Binding;Biological Assay;Biopsy;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cells;checkpoint therapy;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;combinatorial;Combined Modality Therapy;CRISPR/Cas technology;Critical Pathways;Development;Drug Targeting;Frequencies;Gene Expression;Gene Targeting;Generations;Genes;Genetic;Genetic Transcription;Goals;Human;IFNGR1 gene;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune response;immunogenic;Immunosuppression;Immunotherapy;improved;In Vitro;in vivo;in vivo Model;interest;Interferon Type II;IRF1 gene;Knock-out;Knockout Mice;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Melanoma;Melanoma Cell;Melanoma patient;Melanoma Tumor;Metastatic Melanoma;Mission;Modeling;Mus;mutant;Natural Killer Cells;novel;Nuclear;Pathway interactions;Patients;perforin;pharmacologic;phosphoproteomics;Phosphorylation;Phosphorylation Site;Phosphotransferases;Promoter Regions;Proteins;Public Health;Regulation;Regulatory T-Lymphocyte;Relapse;Repression;Research;Resistance;resistance mechanism;response;Role;Signal Pathway;Signal Transduction;Site;Splenocyte;T-Lymphocyte;Testing;therapeutic target;therapy resistant;transcription factor;tumor;Tumor Escape;tumor growth;tumor microenvironment;tumor-immune system interactions;United States National Institutes of Health

PROJECT_TITLE: A novel pathway to overcome resistance to immunotherapy in melanoma

STUDY_SECTION: TIR

STUDY_SECTION_NAME: Therapeutic Immune Regulation Study Section[TIR]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Primary Health Care;Social Determinants of Health

PHR: Medicaid and health systems are investing billions of dollars in programs to address health-related social needs, such as food and housing insecurity, but the effectiveness of these programs on health and medical spending are unknown. The overall objective of this research is to extend and expand on the research team’s current evaluation of a Massachusetts Medicaid food and housing insecurity program (i.e., Flexible Services) funded by a Section 1115 waiver to determine the program’s impact on health-related social needs, health, and health care use and spending. Rigorous evaluation of this ongoing natural experiment will provide essential data to guide other states and health systems and inform national policy decisions.

PI_NAMEs: THORNDIKE, ANNE N (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: accountable care organization;Acute;Address;Adult;Anxiety;Arkansas;Blood Pressure;Cardiovascular Diseases;contextual factors;cost;COVID-19 pandemic;Data;Data Collection;Diabetes Mellitus;Diet;Effectiveness;Electronic Health Record;electronic health system;Emergency department visit;Enrollment;Ensure;Evaluation;experience;experimental study;flexibility;follow-up;Food;food insecurity;food security;Funding;Glycosylated hemoglobin A;Health;health assessment;health care service utilization;health equity;Health system;Healthcare;Hospitalization;Housing;housing instability;Hypertension;implementation determinants;implementation evaluation;improved;Inpatients;Intervention;Interview;Investments;Knowledge;Link;Maintenance;Massachusetts;Medicaid;Medical;medication compliance;member;Mental Depression;Mental Health;Methods;Natural experiment;Neighborhood Health Center;Non-Insulin-Dependent Diabetes Mellitus;novel;nutrition;Obesity;Oregon;Outcome;pandemic disease;Participant;patient oriented;Patients;Phase;Policies;Population;Practical Robust Implementation and Sustainability Model;Program Effectiveness;Program Sustainability;programs;prospective;Prospective cohort;psychological outcomes;psychosocial outcome;Quality of life;Ramp;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Research;service organization;service programs;Services;social;Social Work;Standardization;Stress;Surveys;United States Centers for Medicare and Medicaid Services;waiver

PROJECT_TITLE: LiveWell 2: Assessment of a Medicaid ACO natural policy experiment to address food and housing insecurity

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]