ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: Project Narrative Rates of neonatal opioid withdrawal syndrome (NOWS) have drastically increased in the past decade, with about 80 babies per day born with NOWS, and the combined associated medical and educational costs projected to be more than $400 million, annually. Recent evidence has suggested that inflammation is present as a result of in utero opioid exposure, and, while inflammation is present during periods of withdrawal in adult rodent models of heroin addiction, the molecular mechanisms of withdrawal in NOWS and long-term effects, such as those related to cognition, remain incomprehensible. Utilizing a rat model of NOWS, we will evaluate inflammation as it relates to physical withdrawal symptoms and subsequent cognitive function in associated brain regions to better understand this debilitating and costly disease.

PI_NAMEs: MILLS-HUFFNAGLE, SARA LYNN (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Address;Adult;Amygdaloid structure;Animal Model;Attention;Attenuated;Behavioral;Birth;Brain;Brain region;Brain Stem;career;Characteristics;chemokine;Child;Clinical;clinically relevant;Cognition;Cognitive;Cognitive deficits;cognitive development;cognitive function;cognitive testing;cohort;Compensation;Corpus striatum structure;cost;Cost of Illness;cytokine;Diagnosis;Disease;education cost;emerging adult;endogenous opioids;Evaluation;experience;experimental study;Exposure to;Female of child bearing age;Foundations;Future;Genetic Induction;Heroin;Heroin Dependence;Hippocampus;Hyperactivity;Immunohistochemistry;in utero;indexing;Infant;Inflammation;Inflammatory;inflammatory marker;inhibitor;insight;Intellectual impairment;interest;Intervention;Learning;Life;locus ceruleus structure;Long-Term Effects;Longitudinal Studies;Measures;Medial;Medical Care Costs;Memory;Memory impairment;Microglia;Minocycline;Modeling;Molecular;Molecular Target;Motor Activity;mu opioid receptors;multiplex assay;Mutation;Naloxone;Neonatal;Neonatal Abstinence Syndrome;neonatal brain development;neonate;Neuroglia;Neurons;Neuropeptides;Neurotransmitters;Norepinephrine;novel;Operative Surgical Procedures;Opioid;opioid exposure;opioid use;opioid use disorder;opioid withdrawal;Pennsylvania;Phenotype;physical symptom;Population;postnatal;pre-clinical;Pre-Clinical Model;preadolescence;Pregnancy;Pregnant Women;Proteins;Publishing;pup;Rattus;Regulation;Research;Rewards;Rodent Model;Role;Saline;Source;stem;Symptoms;Syndrome;System;targeted treatment;Techniques;Testing;TLR4 gene;Training;Translational Research;treatment strategy;Ultrasonics;United States;Up-Regulation;vocalization;Weaning;Withdrawal;Withdrawal Symptom;Work

PROJECT_TITLE: Evaluation of inflammation in the locus coeruleus during physical withdrawal symptoms and cognitive development in a rat model of neonatal opioid withdrawal syndrome (NOWS)


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Heart Disease;Human Genome;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: DALLAS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative 22q11.2 deletion syndrome is the most common chromosomal deletion problem reported in humans, leading to multiple clinical problems that affect the immune, heart, and nervous systems. Our recent work is revealing important roles for coding and noncoding RNAs in affecting the severity of the disease. We will use patient studies and mouse models of 22q11.2 deletion syndrome to determine the impact of these RNA species in the formation and function of the thymus.

PI_NAMEs: VAN OERS, NICOLAI STANISLAS CYRILLE (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: 22q11;22q11.2;Affect;Binding Proteins;Biogenesis;Biomedical Engineering;Blood;Blood specimen;Brain;capsule;Cells;Child;Chromosome Deletion;Chromosomes;Cleft Palate;Clinical;Code;comparative;congenital anomaly;Congenital Heart Defects;Coupled;Data;Defect;Deterioration;Development;Developmental Delay Disorders;differential expression;DiGeorge Syndrome;Disease;Embryo;Embryonic Development;Engineering;Epithelial Cells;experimental study;Face;fetal;Fetal Thymic Organ Culture;Genes;Grant;Growth;Heart;Human;Hypoparathyroidism;Immune;immune function;immunodeficiency;Impairment;Individual;Infant;insight;Link;Longitudinal Studies;Lymphopenia;Mediating;Mesenchymal;microdeletion;MicroRNAs;Molecular;mouse model;Nervous System;Neural Crest;Neurologic;Neurophysiology - biologic function;Organoids;Output;Patients;Pattern;peripheral blood;Pharyngeal Apparatus;Pharyngeal pouch;postnatal;Process;Proteins;Pseudogenes;Reporting;RNA;Role;Severities;Severity of illness;single-cell RNA sequencing;Source;Study models;Supporting Cell;Syndrome;T-Cell Development;T-Lymphocyte;thymic aplasia;thymic hypoplasia;Thymic Tissue;Thymus Gland;Tissue Expansion;tissue regeneration;Tissues;Transcript;transcription factor;transcriptome;transcriptome sequencing;Untranslated RNA;Work

PROJECT_TITLE: Coding and Noncoding RNA Contributions to 22q11.2 Deletion Syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-K(52)]


ADMINISTERING_IC: DE

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Cancer;Dental, Oral, and Craniofacial Disease;Radiation Oncology;Rare Diseases

ORG_CITY: LEXINGTON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE The goal of this project is to establish novel optical strategies for rapid systematic metabolic characterization of biological models in vivo to address questions in the field of HNSCC radio-resistance and recurrence using orthotropic HNSCC models. We will also integrate our optical strategies with the state-of-art Stable Isotope- Resolved Metabolomics (SIRM) to provide rapid and comprehensive understanding in tumor metabolism that relates to radio-resistance. Our synergistic approach will provide the metabolic underpinnings of radio- resistance and recurrence and facilitate advances in the understanding of tumor biology, assessment of recurrence risk and design of therapies that can mitigate radio-resistance and recurrence altogether.

PI_NAMEs: ZHU, CAIGANG  (contact)

PROGRAM_OFFICER_NAME: LOPEZ, ORLANDO

PROJECT_TERMS: Address;aerobic glycolysis;Algorithms;angiogenesis;Animal Model;Animals;anti-cancer research;Benchmarking;Bioenergetics;Biological;Biological Assay;Biological Models;Blood Vessels;Cancer Biology;Cancer Model;Cancer Patient;cancer therapy;Citric Acid Cycle;computerized data processing;Development;Devices;Dimensions;Disease;extracellular;Fiber;Genes;Genetic;genome editing;Genus Hippocampus;Geometry;glucose uptake;Glycolysis;Goals;Guidelines;Head and Neck Squamous Cell Carcinoma;Hemoglobin;Human;Immunohistochemistry;improved;in vivo;in vivo Model;insight;lens;Lipids;Malignant Neoplasms;Measurement;Measures;Mediating;Membrane Potentials;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methodology;mitochondrial membrane;mitochondrial metabolism;Modeling;Monitor;nanoparticle;novel;Optics;Outcome;overexpression;Oxygen;Oxygen Consumption;point of care;prevent;Proteins;Publishing;radiation resistance;Radiation therapy;Radiation Tolerance;radioresistant;ratiometric;Recurrence;Risk;Spectrum Analysis;stable isotope;Stains;Survival Rate;System;Targeted Radiotherapy;Techniques;Technology;Testing;therapy design;Tissues;tool;Treatment Efficacy;trend;tumor;Tumor Biology;tumor metabolism;Validation;vector;Viral

PROJECT_TITLE: Point-of-care optical spectroscopy platform and novel ratio-metric algorithms for rapid and systematic functional characterization of biological models in vivo

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Narrative Protein allostery is a fundamental phenomenon in which ligand binding at one site affects substrate activity or ligand binding at a second, distal site of the protein. Allostery is a primary mode of regulation for enzymes and other proteins that drive signal transduction and metabolism, and it is now being used in some drug development efforts, even though the mechanisms of allostery are not well understood. The work in this project will characterize dynamics and allosteric communication pathways for the homodimeric enzymes chorismate mutase and thymidylate synthase, and for engineered optogenetic conformational switch proteins.

PI_NAMEs: LEE, ANDREW L (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Address;Affect;Allosteric Regulation;Antineoplastic Agents;Area;Attention;base;Behavior;Binding Sites;Biochemistry;Biology;biophysical analysis;biophysical techniques;Calorimetry;Catalysis;chemical conjugate;Chemistry;Chorismate Mutase;Communication;dimer;Distal;drug development;drug discovery;Engineering;Enzymes;Escherichia coli;Exhibits;falls;flexibility;Fluorouracil;Foundations;Goals;Guanosine Triphosphate Phosphohydrolases;Human;improved;interest;Investigation;Label;Laboratories;Ligand Binding;Ligands;Metabolism;Molecular Conformation;molecular dynamics;Movement;Nature;NMR Spectroscopy;optogenetics;Pathway interactions;Property;Protein Engineering;protein function;Proteins;Protomer;Regulation;Relaxation;Role;Signal Transduction;Signaling Protein;Site;small molecule;Structure;System;Technology;Thymidylate Synthase;Work;X-Ray Crystallography;Yeasts

PROJECT_TITLE: Mechanisms and dynamics of allosteric function in proteins

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Networking and Information Technology R&D (NITRD);Pancreatic Cancer;Rare Diseases

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

ORG_STATE: CA

PHR: PROJECT NARRATIVE – Administrative and Biostatistics Core Pancreatic ductal adenocarcinoma is a highly lethal malignancy that will soon become the second-leading cause of cancer-related death, in large part because patients often exhibit inherent and/or adaptive resistance to therapy. This program project will explore the epigenetic programs, signaling pathways, and metabolic adaptations that drive therapeutic resistance, with the end goal of revealing new therapeutic targets. The Administrative and Biostatistics Core will provide the leadership framework, communication pipelines, project management services, biostatistical expertise, and data storage/sharing solutions necessary to coordinate the activities of the three Research Projects and three Shared Resource Cores that comprise this P01 effort, thereby providing an organizational foundation for success.

PI_NAMEs: HUNTER, TONY R. (contact)

PROJECT_TERMS: Adopted;Bioinformatics;Biometry;Biostatistics Core;Cancer Etiology;Cessation of life;Collaborations;Communication;Communities;cost effective;Data;Data Analyses;Data Analytics;data exchange;data integration;Data Set;data sharing;Data Storage and Retrieval;Decision Making;Deposition;Disparate;Ensure;Epigenetic Process;Exhibits;Experimental Designs;experimental study;Faculty;Foundations;Future;Goals;Heterogeneity;Information Technology;Lead;Leadership;Malignant neoplasm of pancreas;Malignant Neoplasms;meetings;member;Metabolic;Methods;Monitor;new therapeutic target;novel;organizational structure;Pancreatic Ductal Adenocarcinoma;Patients;programs;public repository;Reagent;Recommendation;Reporting;Reproducibility;Research;Research Project Grants;Resource Sharing;Resources;response;Risk;Services;Signal Pathway;success;System;therapy resistant;tumor;Work

PROJECT_TITLE: Administrative and Biostatistics Core


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Rare Diseases

PHR: PROJECT NARRATIVE – Core 1: Tumor and Microenvironment Heterogeneity Core The Tumor and Microenvironment Heterogeneity Core (TMH Core) will provide essential support for all three Projects in their efforts to delineate tumor and stromal cell programs that underlie therapeutic resistance in pancreatic ductal adenocarcinoma (PDA). Specifically, the TMH Core will assist with digital spatial profiling of tissues, quantitative and functional characterization of tumor immune cells, and single-cell transcriptomic and epigenomic experiments, as well as provide the necessary bioinformatic and computational support to effectively utilize the resulting data. In combination, these services will facilitate the determination of how heterogeneity in cell type-specific function and localization contributes to therapeutic resistance in PDA.

PI_NAMEs: KAECH, SUSAN M (contact)

PROJECT_TERMS: Affect;analysis pipeline;ATAC-seq;Automobile Driving;Autophagocytosis;base;Bioinformatics;Biological Assay;Biometry;Biostatistics Core;Blood Vessels;Cancer Biology;Cell Separation;cell type;Cells;Characteristics;Collaborations;Collection;Complement;Complex;cytokine;Data;Data Analyses;Data Set;Dedications;deep sequencing;design;Desmoplastic;digital;Disease;Dissociation;DNA;Ecosystem;effective therapy;Ensure;Epigenetic Process;epigenomics;Exclusion;Experimental Designs;experimental study;extracellular;Extracellular Matrix;Fibroblasts;Flow Cytometry;Genetic Transcription;Genome Mappings;genome-wide;genomic locus;Genomics;Goals;Growth;Heterogeneity;Human;Hypoxia;Image;Immune;Immune Evasion;Immune response;Immunology;Individual;Inflammation Mediators;Inflammatory;Infrastructure;insight;interest;Knowledge;Lead;Libraries;Link;Macrophage;Malignant Neoplasms;Maps;Massive Parallel Sequencing;Measures;Metabolic;mouse model;Mus;nano-string;Neoplasm Metastasis;neoplastic cell;neutrophil;Normal tissue morphology;novel;Organoids;Pancreatic Ductal Adenocarcinoma;Pharmaceutical Preparations;Phenotype;Preparation;programs;protein expression;Proteomics;reference genome;Refractory;Research Personnel;response;RNA;Role;Services;Signal Transduction;single cell analysis;single cell ATAC-seq;single cell genomics;single-cell RNA sequencing;Specimen;Standardization;Stromal Cells;T-Lymphocyte;Technology;Testing;Therapeutic;therapy resistant;Tissues;transcription factor;Transcriptional Regulation;transcriptomics;Treatment Efficacy;treatment response;tumor;Tumor Cell Invasion;tumor growth;tumor heterogeneity;tumor microenvironment;tumor-immune system interactions;Tumor-infiltrating immune cells;Variant;Work

PROJECT_TITLE: Core 1: Tumor and Microenvironment Heterogeneity Core (TMH Core)


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_CITY: RALEIGH

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: RELEVANCE TO PUBLIC HEALTH The knee meniscus has a unique mechanical function that is dictated by its three-dimensional (3D) structure, and injuries to the meniscus represent a large socioeconomic problem. The overall goal of this proposal is to develop a bioactive nonwoven scaffold that recapitulates the complex multiscale structural and mechanical characteristics of the meniscus and assess its long-term function and the ability to prevent joint degeneration in- vivo. On completion, fundamental knowledge gained about the micro- and macro-level process-structure- function relationships using our new high throughput 3D nonwovens approach can be extended to develop new and translational technologies for the treatment of injuries to other important tissues, including the intervertebral disc, ligaments, and tendons.

PI_NAMEs: FISHER, MATTHEW B (contact);MCNULTY, AMY L;SHIRWAIKER, ROHAN

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: 3-Dimensional;3D Print;Anatomy;Architecture;base;Behavior;bioactive scaffold;Biological;Biomechanics;Biopolymers;cartilage degradation;Cell Culture Techniques;Cell Differentiation process;Cell Survival;Cells;Characteristics;clinical application;Clinical Treatment;Collagen;Complex;Control Groups;Cues;Data;design;Diameter;Electrospinning;Engineering;Extracellular Matrix;fabrication;Family suidae;Fiber;Formulation;Geometry;Goals;Hybrids;Implant;improved;In Vitro;in vivo;Infiltration;Injury;Intervertebral disc structure;joint destruction;Joints;Knee;Knee Injuries;Knowledge;Ligaments;mechanical properties;Mechanics;melting;meniscal tear;meniscus injury;Meniscus structure of joint;Modeling;Morphology;novel;Operative Surgical Procedures;Orthopedics;Outcome;Patient-Focused Outcomes;Patients;Physiological;Polyesters;Polymers;Polyurethanes;Porosity;prevent;Process;Production;Property;Proteomics;Public Health;Regenerative Medicine;repair model;repaired;Reporting;Reproducibility;Research;scaffold;Shapes;socioeconomics;Soft Tissue Injuries;Stifle joint;Structure;Structure-Activity Relationship;Surgical sutures;Synovial Cell;System;Techniques;Technology;Tendon structure;Testing;three dimensional structure;Tissue Engineering;Tissues;translational approach;Work

PROJECT_TITLE: Using 3D Nonwovens Fabrication to Engineer Region-Specific Extracellular Matrix Structure and Bioactivity of the Knee Meniscus

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: Project Narrative Infectious diseases are leading causes of death in newborns who have distinct immunity and metabolic needs. Vaccines are the most effective biomedical intervention to prevent infection and may confer off-target health benefits, but the mechanisms by which they do so are incompletely characterized in early life. The proposed research will explore the effects of Bacille Calmette-Guérin (BCG) vaccine, given yearly to ~150 million newborns across the globe, on neonatal immunity and cellular metabolism to identify molecular signatures of broad vaccine protection against infection that can be harnessed to optimize current and future vaccines tailored to the very young.

PI_NAMEs: ANGELIDOU, ASIMENIA  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Acetyl Coenzyme A;adaptive immunity;Adult;Advisory Committees;age related;alpha ketoglutarate;Attenuated;Award;BCG Live;BCG Vaccine;Bioenergetics;Biological Assay;Birth;Blood specimen;Boston;career;career development;Cause of Death;chemokine;Childhood;clinical training;cofactor;cohort;Communicable Diseases;cytokine;Data;Development;Disease;Enzyme Inhibitor Drugs;Enzymes;epidemiology study;Epigenetic Process;experience;experimental study;Exposure to;Funding;Future;Glycolysis;Goals;Health;Health Benefit;Human;human model;Immune;immune activation;Immune system;Immune Tolerance;Immunity;Immunization;Immunize;Immunologic Memory;Immunology;immunoregulation;Impairment;In Vitro;in vitro Assay;in vitro Model;in vivo;Infant;Infection;Infection prevention;innate immune mechanisms;insight;instructor;Intervention;Israel;Leukocytes;Life;Link;Lipids;Mass Spectrum Analysis;Mediating;Mediator;Medical center;medical schools;Mentors;Mentorship;Metabolic;Metabolic Pathway;Metabolism;metabolome;metabolomics;Molecular;Molecular Profiling;monocyte;Morbidity - disease rate;mortality;multidisciplinary;Mycobacterium bovis;National Institute of Allergy and Infectious Disease;Neonatal;neonatal human;neonatal immunity;neonatal morbidity;Neonatal Mortality;neonate;Neonatology;Newborn Infant;novel;Participant;pathogen;Pathway interactions;Pediatric Hospitals;Pediatrics;Peripheral;Phenotype;Plasma;prevent;Program Development;programs;Publishing;randomized trial;receptor;Research;Respiratory Tract Infections;response;Scientist;Sepsis;Shapes;skills;Small Interfering RNA;Stimulus;Succinates;Systems Biology;Techniques;Training;Tuberculosis;Tuberculosis Vaccines;Vaccination;vaccine development;vaccine formulation;vaccine response;Vaccines;vaccinology;Vulnerable Populations;Whole Blood;Work;World Health Organization

PROJECT_TITLE: Immunometabolic signatures of BCG-induced neonatal trained immunity

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ROCHESTER

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Project Narrative This project is relevant to public health because it addresses a novel mechanism by which interactions of aggressive cancers such as acute myeloid leukemia (AML) with their niche can promote disease progression. If successful, this work will provide a scientific basis for development of new strategies to treat these aggressive cancers with less than 25% survival rates. This is highly relevant to the NIH mission of developing fundamental knowledge to help reduce the burdens of human disability.

PI_NAMEs: BAJAJ, JEEVISHA  (contact)

PROGRAM_OFFICER_NAME: SAYYED, ZULEKHA I

PROJECT_TERMS: Activities of Daily Living;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Adhesives;adult stem cell;Blast Phase;Bone Marrow;cancer cell;Cell Death;Cell Line;Cell surface;Cells;Chronic Myeloid Leukemia;comparison control;CRISPR screen;Data;Data Set;Development;disability;Disease;disease model;Disease Progression;Endothelial Cells;Environment;Enzymes;Genes;Genetic;genome-wide;Goals;Growth;Growth Factor;Hematopoiesis;Hematopoietic stem cells;Human;Impairment;In Vitro;in vivo;interest;knock-down;Knowledge;leukemia;Leukemic Cell;leukemic stem cell;leukemogenesis;Malignant Neoplasms;Mediating;Mission;MLL-AF9;mouse model;Mus;Mutation;Myelogenous;Myeloid Leukemia;myeloid leukemia cell;Myeloproliferative disease;new therapeutic target;Non-Essential Amino Acid;novel;Oncogenes;Osteoblasts;osteogenic;osteoprogenitor cell;Patients;Pilot Projects;Prognosis;Proliferating;Public Health;Receptor Signaling;reconstitution;Resistance;Role;self-renewal;Signal Transduction;single-cell RNA sequencing;small hairpin RNA;stem cell self renewal;stem cells;Stromal Cells;Surface Antigens;Survival Rate;Taurine;taurine transporter;Testing;The Cancer Genome Atlas;therapy resistant;transcriptome sequencing;United States National Institutes of Health;Work;Xenograft Model

PROJECT_TITLE: Targeting Microenvironmental Signals in Myeloid Malignancies

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

PHR: PROJECT NARRATIVE – Core 2: Human Specimen and Organoid Core The Human Specimen and Organoid Core (HSO Core) will provide expertise and essential resources for all three Research Projects in their efforts to develop effective approaches for overcoming therapeutic resistance in pancreatic ductal adenocarcinoma (PDA). The HSO Core will leverage a large biobank of patient-derived organoid models as well as organotypic slice models that recapitulate the PDA microenvironment to test therapeutic combinations and define novel vulnerabilities. The HSO core will also collaborate with the Project teams to develop novel mouse organoid cultures and co-culture systems that incorporates cell types that define the tumor microenvironment to interrogate signaling networks ex vivo.

PI_NAMEs: TIRIAC, HERVE  (contact)

PROJECT_TERMS: 3-Dimensional;Autophagocytosis;biobank;Biological Assay;Cancer Center;cell type;Cells;Chemoresistance;Coculture Techniques;cohort;Collaborations;Combination Drug Therapy;Combined Modality Therapy;Complement;Complex;curative treatments;Data Set;Diagnosis;Disease;Dissection;DNA;Drug resistance;drug sensitivity;drug testing;Ensure;Epigenetic Process;Epithelium;Excision;Fibroblasts;Fluorouracil;gemcitabine;Generations;Genetic;Genetically Engineered Mouse;Genomics;Goals;Hour;Human;Human Characteristics;human disease;human model;Immune;Immunocompetent;in vivo;Incidence;Individual;inhibitor;irinotecan;KRAS2 gene;Leucovorin;Libraries;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;Mathematics;Metabolism;Methodology;Modeling;Molecular;mouse model;Mus;mutant;neoplastic;next generation;novel;novel therapeutics;Operative Surgical Procedures;Organoids;oxaliplatin;Paclitaxel;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;pancreatic stellate cell;patient response;Patients;Pharmaceutical Preparations;Phenotype;Physiological;predictive signature;preservation;quality assurance;Quality Control;Quality of life;Receptor Protein-Tyrosine Kinases;Refractory;Reproducibility;Research;Research Personnel;Research Project Grants;Resistance;Resistance development;resistance mechanism;Resource Sharing;Resources;response;Signal Transduction;Slice;Specimen;stem;Stromal Cells;Survival Rate;synergism;System;targeted treatment;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;therapeutically effective;therapy resistant;Time;TP53 gene;Training Programs;transcriptome sequencing;transcriptomics;Transplantation;Treatment Effectiveness;Treatment Protocols;treatment response;tumor;tumor microenvironment;tumorigenic;Validation

PROJECT_TITLE: Core 2: Human Specimen and Organic Core (HSO Core)


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Cardiovascular;Dementia;Genetics;Heart Disease;Human Genome;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: SYRACUSE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: Many older adults show the biological signs of Alzheimer's disease yet remain cognitively intact; it may be useful to identify and harness the factors that influence such resilience. Here we propose to catalog the genes, molecules, brain structures, and clinical features that increase risk for Alzheimer's disease, and determine how those factors relate to the emergence of cognitive deterioration over time on the path to dementia. Our findings may help clinicians accurately predict, diagnose, treat, and even prevent cognitive decline over time, and also may help scientists understand the biology of resilience to Alzheimer's disease.

PI_NAMEs: HESS, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: Acceleration;Accounting;Address;adversarial learning;Aging;Algorithms;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease risk;Applied Genetics;Automobile Driving;Bioinformatics;Biological;Biology;Blood;Brain;brain based;Brain Diseases;Brain imaging;Cardiac;cardiovascular disorder risk;Cardiovascular system;Catalogs;Clinical;clinical risk;Cognition;Cognitive;cognitive performance;cohort;Complex;Data;data imputation;deep neural network;Dementia;demographics;Deterioration;Diagnosis;Diagnostic;differential expression;Dimensions;Disease;Disease Progression;experience;Functional disorder;Functional impairment;Gene Expression;gene interaction;gene network;Genes;Genetic;genetic architecture;Genetic Risk;genome wide association study;Genomics;Genotype;Genotype-Tissue Expression Project;Heart;Human;Impaired cognition;improved;indexing;Individual;insight;Institution;interest;Intervention;Investigation;Knowledge;Measurement;Measures;Mediating;Medical Research;Memory;mental state;Metabolic;Methods;mild cognitive impairment;Modeling;Molecular;multiple data types;Myocardial;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;Nervous System Disorder;neural network;Neural Network Simulation;neurobiological mechanism;Neurobiology;neuroimaging;Neuropsychology;novel;novel marker;older adult;Ontology;Outcome;Participant;Pathway interactions;Pattern;peripheral blood;Persons;Pharmaceutical Preparations;Phenotype;Pilot Projects;polygenic risk score;prevent;Recovery;religious order study;Research Institute;resilience;Risk;Risk Factors;risk variant;Scientist;Signal Transduction;Source;Strategic Planning;Structure;Symptoms;System;Testing;Time;Tissue-Specific Gene Expression;Tissues;tool;Training;Transcript;transcriptome;transcriptomics

PROJECT_TITLE: Integrating Genetic, Neuroimaging, Transcriptomic, and Clinical Risk Factors as Multivariate Predictors of Cognitive Deterioration in Alzheimer's Disease.


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Inorganic metals have long been a focus of biomedical research in New Mexico, due to the high prevalence of mining-related metal contaminants in the region. At the University of New Mexico Center for Metals in Biology and Medicine our main focus will be on both studying adverse health outcomes of metal contaminants as well as on harnessing the chemical properties of metals for therapeutic and nutritional purposes. The outcomes of our program have clear benefit to clinical populations and communities in the southwest, including the underserved populations disproportionately impacted by legacy waste from mining operations. 1

PI_NAMEs: CAMPEN, MATTHEW J (contact)

PROGRAM_OFFICER_NAME: MATUKUMALLI, LAKSHMI KUMAR

PROJECT_TERMS: Analytical Chemistry;Area;Binding;Biochemistry;biological systems;Biology;Biomedical Research;Cancer Biology;career;career development;Centers of Research Excellence;Characteristics;chemical property;Chemistry;Clinical;Clinical Sciences;Communities;Community Health;community intervention;Community Outreach;Complex;Computers and Advanced Instrumentation;Core Facility;Development;Disease;Drug Delivery Systems;Environmental Hazards;Environmental Health;environmental toxicology;Exhibits;Extramural Activities;Faculty;Funding;Funding Opportunities;global health;Goals;Growth;Health;Health Benefit;Health Sciences;Heavy Metals;High Prevalence;Home;Human;Immunology;improved;innovation;Inorganic Chemistry;Intervention;Investigation;Knowledge;Leadership;Link;Lung;Malignant Neoplasms;Medical;Medicine;member;Mentors;Mentorship;metallicity;Metals;Mexican;Mining;Molecular;Molecular Analysis;multidisciplinary;Native American population;Neurologic;Neurosciences;New Mexico;novel;nutrition;Nutritional;operation;Outcome;Patients;Physiology;Play;Population;Prevalence;Principal Investigator;Productivity;programs;Property;Public Health;receptor;Recording of previous events;Research;Research Personnel;Research Training;Resources;Risk Assessment;Role;Science;Scientist;Services;Southwestern United States;Therapeutic;Tissue Model;Toxicology;Toxin;Training;Transition Elements;Translational Research;Underserved Population;Universities;wasting;Work


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Acceleration;Address;Advisory Committees;Analytical Chemistry;Area;Award;Biochemistry;Biological;biological systems;Biology;Biomedical Research;Cancer Biology;carcinogenesis;career;career development;chemical property;Clinical;Communication;community setting;Computers and Advanced Instrumentation;Development;Ensure;Environmental Pollutants;Evaluation;experience;Extramural Activities;Faculty;Fostering;Foundations;Funding;Funding Opportunities;Future;Goals;Grant;Growth;Health;Human;improved;Infrastructure;innovation;Inorganic Chemistry;Institution;interdisciplinary approach;interest;International;Leadership;Medical;Medicine;member;Mentors;Metals;Methods;Mining;Molecular Analysis;multidisciplinary;New Mexico;Nutritional;Outcome;Pilot Projects;Prevalence;Principal Investigator;Productivity;Program Sustainability;programs;Recording of previous events;recruit;Research;Research Institute;Research Personnel;Research Project Grants;Research Training;Resources;Role;Science;Scientist;Strategic Planning;Strategic vision;success;Talents;Therapeutic;Toxicology;Training;Translational Research;Translations;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Administrative Core


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Primary Health Care;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Despite the ongoing opioid crisis and the availability of effective medications that help individuals with opioid use disorder maintain remission, few health care providers prescribe these treatments, leading to inadequate access to care for patients, especially in rural and other underserved communities. This application will support a new investigator seeking to conduct research that examines the full continuum of dissemination, implementation, and sustainment of substance use disorder treatment, with the goal of identifying effective strategies for aligning the evidence base with actual treatment received by patients. The K01 award will provide mentorship and rich opportunities for developing new research skills and knowledge, enabling the investigator to transition to an independent researcher who will lead national efforts to improve treatment access, reduce drug-related harms, and decrease inequities in access and outcomes.

PI_NAMEs: YARBROUGH, COURTNEY R. (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: Abstinence;Acceleration;access disparities;Accident and Emergency department;addiction;Address;Admission activity;Adopted;Adoption;American;Area;Buprenorphine;Caring;Case Study;Characteristics;Clinical;Communities;community-level factor;Consolidated Framework for Implementation Research;Country;County;Data Set;Dedications;design;deviant;Diffusion;Diffusion of Innovation;Disease remission;Disparity population;Dissemination and Implementation;Drug Prescriptions;Effectiveness;empowerment;Ethnic Origin;evidence base;Evidence based practice;Formulation;Foundations;Future;Geography;Goals;Health Personnel;Health Services Accessibility;Health system;implementation facilitators;implementation framework;implementation process;implementation science;implementation strategy;improved;improved outcome;Incentives;Income;Individual;Inequity;Influentials;innovation;insight;Interview;Knowledge;Lead;Maintenance Therapy;Measures;medication for opioid use disorder;Medicine;Mentored Research Scientist Development Award;Mentors;Mentorship;Methadone;Methods;Modeling;mortality;Naltrexone;National Institute of Drug Abuse;Nonpharmacologic Therapy;novel;novel strategies;Opioid;opioid epidemic;opioid mortality;opioid use disorder;Outcome;Overdose;Pain;Patient Care;Patients;peer;Pharmaceutical Preparations;Pharmacists;Pharmacotherapy;Physicians;Policies;Portraits;Prevalence;Primary Care;primary care provider;primary care setting;Process;professor;Provider;psychosocial;Public Health;Public Health Schools;Qualitative Methods;Race;Recommendation;Regulation;Reporting;Research;Research Personnel;resilience;Resources;Rural;rurality;Sales;skills;Socioeconomic Status;Structure;Subgroup;Substance Use Disorder;System;system-level barriers;Testing;Theoretical model;theories;Time;Training;training opportunity;Treatment outcome;underserved area;underserved community;Universities;waiver;Withdrawal;Work

PROJECT_TITLE: Opioid Treatment Adoption in Primary Care Settings: Barriers and Facilitators to Implementation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DIRH-N(09)]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Orphan Drug;Pancreatic Cancer;Rare Diseases

PHR: PROJECT NARRATIVE – Core 3: Mouse Models Core Pancreatic ductal adenocarcinoma is projected to become the second leading cause of cancer death in the United States within the next several years, and an important goal of the NCI has been to develop the knowledge needed to improve diagnostic and treatment strategies for this recalcitrant cancer. Each Project in this P01 proposal is reliant on mouse models to investigate epithelial and stromal interactions that drive both intrinsic and acquired therapeutic resistance, which together contribute to poor outcomes for patients with pancreatic cancer. The Mouse Models Core will work with each Research Project to: 1) investigate hypotheses generated from in vitro model systems using multiple in vivo experimental strategies, 2) test the efficacy and survival benefits of a variety of new therapeutic approaches based on fundamental advances generated by each Project, and 3) assure experimental consistency, rigor, and an economy of scale by serving as a center for performing complex surgeries and orthotopic transplants, and for monitoring survival enhancement in autochthonous models.

PI_NAMEs: WAHL, GEOFFREY MYLES (contact)

PROJECT_TERMS: Affect;Alleles;Animals;Autophagocytosis;Biological Models;Breeding;CA-19-9 Antigen;Cancer Etiology;Cell Compartmentation;Cell Line;Cell Physiology;Cessation of life;chemotherapy;cohort;Collaborations;Complex;Consultations;cost;cost effectiveness;Data;Dedications;design;Development;Diagnostic Procedure;diagnostic strategy;Disease;Disease Resistance;DNA Damage;Drug Combinations;Drug resistance;drug sensitivity;efficacy testing;Enrollment;Ensure;Epigenetic Process;Epithelium;Evaluation;Exhibits;Fibroblasts;Genes;genetic manipulation;Genotype;Goals;Heterogeneity;Histone Deacetylase;Human;Image;imaging modality;Immune;Immune system;Immunotherapy;improved;In Situ;in vitro Model;in vivo;in vivo Model;Injections;Investigational Therapies;Isogenic transplantation;Knowledge;KPC model;Lead;LIF gene;Malignant neoplasm of pancreas;Malignant Neoplasms;Metabolic;Modeling;Monitor;mouse model;Mus;Mutate;neoplastic cell;novel therapeutic intervention;Operative Surgical Procedures;organoid transplantation;Organoids;Pancreas;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;pancreatic tumorigenesis;Paracrine Communication;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;pre-clinical;Procedures;programs;Protocols documentation;Records;Refractory Disease;Regimen;Reproducibility;Reproducibility of Results;Research;Research Project Grants;Resistance;resistance mechanism;response;Role;Services;Standardization;STAT3 gene;success;synergism;Techniques;Testing;Therapeutic;Therapeutic Studies;Therapeutic Trials;therapy resistant;Time;transmission process;Transplantation;Treatment Efficacy;treatment response;treatment strategy;tumor;tumor growth;tumor microenvironment;tumor-immune system interactions;tumorigenesis;tumorigenic;Ultrasonography;United States;Viral;Work

PROJECT_TITLE: Core 3: Mouse Models Core (MM Core)


PHR: INTEGRATIVE MOLECULAR ANALYSIS CORE – PROJECT NARRATIVE The University of New Mexico Center for Metals in Biology and Medicine (UNM CMBM) Integrative Molecular Analysis Core has direct public health relevance as it will improve molecular analysis research and formally integrate existing UNM Health Sciences Center scientific resources, to foster research training and productivity for mentored investigators, as well as to bolster research quality and depth for our institute. Enhancing our molecular analysis capabilities will further strengthen capacity, quality, and impact of biomedical research for UNM as a whole, as the UNM CMBM will promote synergy primarily in the areas of cancer biology, nutrients and environmental health sciences.

PI_NAMEs: FENG, CHANGJIAN  (contact)

PROJECT_TERMS: advanced analytics;Analytical Chemistry;Area;base;Biochemistry;Biological;biological systems;Biology;Biomedical Research;Cancer Biology;Cells;Centers of Research Excellence;cohort;Collaborations;Communities;Complex;Computers and Advanced Instrumentation;Consultations;Core Facility;cost effective;Data Analyses;Dedications;design;Development;Disease;Educational workshop;Ensure;Environmental Health;Equipment;Faculty;Fostering;Funding;Goals;Growth;Health Sciences;Human Resources;improved;in vivo;Individual;Inductively Coupled Plasma Mass Spectrometry;innovation;Institution;instrumentation;Interdisciplinary Study;Investigation;Knowledge;knowledgebase;Laboratory Research;Leadership;Mass Spectrum Analysis;Mediating;Medicine;member;Mentors;Metals;Methodology;Methods;Modernization;Molecular;Molecular Analysis;multidisciplinary;New Mexico;novel;novel therapeutics;Nutrient;Outcome;outreach;Oxidative Stress;Persons;Price;Productivity;programs;protocol development;public health relevance;Reproducibility;Research;research facility;Research Personnel;Research Support;Research Training;Resources;Sampling;Schedule;Science;Scientific Advances and Accomplishments;Scientist;Services;Specialist;Spin Trapping;Strategic vision;Structure;Students;synergism;Technical Expertise;Technology;tool;Trace metal;Training;training opportunity;United States National Institutes of Health;Universities;web page;Work

PROJECT_TITLE: Integrative Molecular Analysis Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: HADLEY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: PROJECT NARRATIVE Patients undergo bladder reconstruction to improve or recover normal urinary function that has been impaired due to non-malignant conditions or as a consequence of surgical treatment of bladder cancer. Herein we propose the application of intrasurgical irreversible electroporation to decellularize an intestinal segment, engineering different types of tissue scaffolds that can aid bladder regeneration, further augmented by a biochemical agonist that can simulate the effects of mechanotransduction. The anticipated clinical impact is to improve the outcomes of reconstructive bladder surgery by reducing patient morbidity and through sustained increase in long-term bladder function, where the significance of our proposed work is underscored by the creation of new tools and techniques for tissue engineering and regenerative medicine.

PI_NAMEs: SRIMATHVEERAVALLI, GOVINDARAJAN  (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Acceleration;Agonist;Autologous Transplantation;Basement membrane;Biochemical;Biocompatible Materials;Bioreactors;Bladder;bladder surgery;Blood Vessels;Cell Death Induction;Cell Differentiation process;cell killing;Cells;Cicatrix;Clinic;Clinical;Congenital Disorders;Data;Development;efficacy evaluation;electric field;Electroporation;Engineering;Esophagus;Extracellular Matrix;Family suidae;Frequencies;Functional Regeneration;Gastrointestinal tract structure;Heterogeneity;Histocompatibility;Immunohistochemistry;Impairment;improved;improved outcome;in silico;In Vitro;in vivo;Inflammation;innovation;Intestines;knock-down;Knowledge;Malignant neoplasm of urinary bladder;Malignant Neoplasms;manufacture;Mechanics;mechanotransduction;Metabolic;Metabolic acidosis;Modeling;Molecular Biology Techniques;Morbidity - disease rate;Mucous Membrane;Natural regeneration;Neurogenic Bladder;new technology;Non-Malignant;novel;Operative Surgical Procedures;Organ;Pathway interactions;Patients;Pelvis;Perfusion;Phenotype;Physiologic pulse;Physiological;Piezo 1 ion channel;Population;porcine model;preservation;Production;Rattus;reconstruction;Reconstructive Surgical Procedures;Regenerative Medicine;Research;Research Design;response;Risk;Role;Safety;Second Primary Cancers;Small Intestinal Submucosa;Smooth Muscle Myocytes;Source;standard of care;Stretching;Techniques;Technology;Tissue Engineering;tissue support frame;Tissues;tool;Trachea;Translating;Translations;Tubular formation;tumor ablation;urinary;Urinary Diversion;urogenital tract;Urothelium;voltage;Work

PROJECT_TITLE: Intrasurgical tissue engineering of autologous grafts using irreversible electroporation for bladder reconstruction

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: WASHINGTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Public Health Relevance A relationship-centered shared decision-making process assessment can improve the quality of care for severely and chronically disabled persons who cannot participate in decision-making due to limited cognitive capacities and their care partners by identifying observable, modifiable collaboration and information exchange skills that impact equitable and transparent shared decision-making.

PI_NAMEs: MALLINSON, TRUDY RUTH (contact);PAPADIMITRIOU, CHRISTINA

PROGRAM_OFFICER_NAME: ZHANG, XINZHI

PROJECT_TITLE: Developing a Standardized Process Assessment for Relationship-Centered Shared Decision-Making (SPARCSdm)

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


NIH_SPENDING_CATS: Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Lung;Women's Health Research

PI_NAMEs: BOLT, ALICIA M. (contact)

PROJECT_TERMS: Accidents;Address;Affect;Animals;Automobile Driving;Biology;Birth;bone;Bone Marrow;Brain;breast cancer metastasis;Breast Cancer Patient;breast cancer progression;breast tumorigenesis;cancer therapy;carcinogenesis;carcinogenicity;cell growth;Cells;chemokine;Classification;cohort;Complex;Cues;cytokine;Data;Development;Epidemiology;exposed human population;exposure route;Exposure to;Fibroblasts;Growth;Growth and Development function;Health;Heavy Metals;Human;Immune;implantation;In Vitro;in vivo;in vivo Model;Industrialization;Industry;Inhalation;Intraoperative Radiation Therapy;Invaded;Investigation;Knowledge;Liver;Lung;lung metastatic;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Measures;Mediating;Mediator;Medicine;mesenchymal stromal cell;Metals;Metastatic Neoplasm to the Lung;Mining;Molecular Mechanisms of Action;mouse model;Mus;Navajo;Neoplasm Metastasis;neoplastic cell;New Mexico;novel;novel therapeutic intervention;Oral;pharmacologic;Play;Population;Process;Proteins;Radiation therapy;recruit;Reporting;Research;Risk;Role;Route;Site;Soil;Source;Surveys;Testing;Time;Toxic Environmental Substances;toxicant;Toxicology;tumor;Tumor Cell Invasion;tumor microenvironment;tumor progression;Tumor Promotion;tumorigenesis;tumorigenic;Tungsten;tungsten carbide;Universities;urinary;wasting;Woman;Work

PROJECT_TITLE: Tungsten and Breast Cancer: Impact of the Tumor Microenvironment


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Genetics;Lung;Lung Cancer;Prevention

PI_NAMEs: ZHOU, XIXI  (contact)

PROJECT_TERMS: Address;Agar;Amino Acids;Arsenic;Arsenic Trioxide;Arsenites;Base Excision Repairs;Binding;Biochemical;Biological;Biology;biophysical techniques;Cancer Etiology;cancer stem cell;carcinogenesis;carcinogenicity;Cell Line;cell transformation;Cells;Chronic;cigarette smoke;Classification;Code;Communities;cytotoxicity;Development;DNA Binding;DNA Damage;DNA Repair;DNA Repair Gene;DNA Repair Inhibition;Dose;Dust;Environment;Epithelial Cells;Epithelium;exome sequencing;exposure route;Exposure to;Foundations;Generations;Genes;Genome;genome sequencing;Goals;Growth;Health;Human;Impairment;improved;Ingestion;Inhalation;insight;Knowledge;Lung;lung carcinogenesis;Malignant neoplasm of liver;Malignant neoplasm of lung;Mediating;Medicine;Metals;Modification;Molecular;mortality;Mutagenesis;Mutation;Nature;New Mexico;novel;Open Reading Frames;oxidative DNA damage;Oxidative Stress;Parents;Particulate;Particulate Matter;Poly(ADP-ribose) Polymerases;Population;Prevention;Process;Property;Proteins;Reactive Oxygen Species;repaired;Risk;Risk Assessment;Risk Management;Site;Skin;Solubility;Somatic Mutation;Source;Specificity;Surface;Tail;Testing;Time;Universities;uptake;Urinary tract;Urologic Cancer;whole genome;Work;Zinc

PROJECT_TITLE: Mutagenesis and Carcinogenesis of Particulate Arsenic in Lung


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Patient Safety;Prevention;Sleep Research

ORG_CITY: CORVALLIS

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Poor sleep health is an underappreciated risk factor for disease, death, errors, and accidents among shift workers, who make up 20% of the US workforce. The purpose of the proposed K23 is to prepare the applicant for an independent clinical sleep research career by developing, refining, and pilot-testing a comprehensive, personalized, media-augmented telehealth intervention designed to improve sleep health among shift workers. This proposal will address the critical lack of evidence-based, accessible interventions by targeting shift workers' unique sleep health problems which manifest during both sleep (e.g., insomnia symptoms, short sleep duration) and wake (e.g., fatigue, sleepiness, poor executive function, depressive symptoms).

PI_NAMEs: DIETCH, JESSICA R (contact)

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: acceptability and feasibility;Accidents;actigraphy;Address;adequate sleep;Area;Automobile Driving;barrier to care;Biology;cardiovascular disorder risk;Care given by nurses;career;career development;Cessation of life;circadian;circadian biology;Circadian Dysregulation;Circadian Rhythms;Clinical;Clinical Investigator;clinical training;Clinical Trials Design;Cognitive Therapy;comparison control;Complement;Conduct Clinical Trials;Confidence Intervals;Data;depressive symptoms;design;Development;Development Plans;diaries;Dimensions;Discipline of Nursing;Disease;disorder risk;Drowsiness;Education;effective intervention;Enrollment;evidence base;executive function;experience;Fatigue;feasibility research;Feedback;flexibility;follow-up;Food Services;Future;Grant;Health;health assessment;Heart Diseases;Hematological Disease;Hour;Impairment;implementation facilitation;implementation science;improved;improvement on sleep;Individual;Intervention;intervention refinement;Lung Diseases;Malignant Neoplasms;Manuals;Manuscripts;Measures;Medical Errors;meetings;Mental Depression;Mentors;Mentorship;Metabolic Diseases;mortality;multidisciplinary;Napping;National Heart, Lung, and Blood Institute;novel;novel therapeutic intervention;Nurses;Occupations;Outcome;Participant;Pathway interactions;Patient Compliance;patient handout;Patients;Personal Satisfaction;Phototherapy;Pilot Projects;pilot test;poor sleep;Population;power analysis;Preparation;prevent;programs;Public Health;Randomized;Randomized, Controlled Trials;Recommendation;Reporting;Research;Research Design;Research Project Grants;Research Training;Risk;Risk Factors;Rotation;Safety;Schedule;secondary outcome;Series;shift work;Sleep;Sleep Disorders;Sleep disturbances;sleep health;sleep pattern;Sleeplessness;Stroke;Structure;Symptoms;telehealth;Testing;therapy design;Time;Training;Training Activity;Transportation;trial comparing;Underserved Population;usability;Visit;Work

PROJECT_TITLE: Developing a sleep health intervention for shift workers

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Colorectal Cancer;Digestive Diseases;Nutrition

PI_NAMEs: XUE, XIANG  (contact)

PROJECT_TERMS: Affect;Animal Model;Aspartate;Automobile Driving;Biology;cancer cell;Cancer Etiology;cancer genomics;Cancer Model;cancer risk;Carbamyl Phosphate;cBioPortal;cell growth;Cell Proliferation;Cell Survival;Cells;Cessation of life;Clinic;Colon;colon cancer patients;colon carcinogenesis;colon tumorigenesis;Colonic Neoplasms;Colorectal Cancer;colorectal cancer progression;Consumption;Data;Deferoxamine;Development;Diet;Dihydroorotase;DNA biosynthesis;DNA Polymerase III;DNA-Directed DNA Polymerase;Enzymes;epidemiology study;Exhibits;Future;Genetic;Glucose;glucose metabolism;Glutamine;Glycolysis;Goals;Growth;Human;Hypoxia;improved;Incidence;inhibitor;Iron;Iron Chelating Agents;Iron Chelation;iron supplement;Knock-out;Knowledge;Ligase;Link;Macronutrients Nutrition;Malignant Neoplasms;MCC gene;Measures;Mediating;Medicine;Metabolic;Metabolism;metabolomics;Metals;Methods;Molecular;Mus;neoplastic cell;New Mexico;Normal Cell;novel therapeutic intervention;novel therapeutics;Nucleotide Biosynthesis;nucleotide metabolism;Pathway interactions;Patients;PDH kinase;Pentosephosphate Pathway;pharmacologic;Polymerase;Proliferating;Pyrimidine;Repression;Role;Signal Transduction;SLC2A1 gene;stable isotope;Testing;therapeutic target;Tissues;TP53 gene;transcarbamylase;tumor;tumor growth;Universities;Uridine Kinase;Work

PROJECT_TITLE: Profiling iron-regulated metabolic reprogramming for nucleotide biosynthesis in colon tumors


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA CITY VA MEDICAL CENTER

ORG_STATE: OK

PHR: Stroke represents a major cause of death and disability in our elderly veterans. Stroke also represents a critical, and potentially preventable, risk factor for cognitive decline mostly in the form of vascular cognitive impairment. Silent brain infarctions are a recently recognized manifestation of covert cerebrovascular disease, without obvious clinical deficit, strongly linked to increased rates for both stroke and cognitive decline. Identifying early markers of stroke risk in all veterans is crucial for developing novel prevention and effective treatment strategies. An increased understanding of mechanisms responsible for silent brain infarcts will improve health care delivery for veterans by identifying potential targets for preventive pharmacological interventions that involve platelet reactivity in the preclinical stage of stroke. This will, in turn, lead to improved quality of life, better medical care and a decreased financial burden for the VA and for society as a whole.

PI_NAMEs: PRODAN, CALIN IOAN (contact)

PROJECT_TERMS: Aging;Aspirin;Biological Markers;Blood Platelets;Brain Infarction;Caring;Cause of Death;Cerebrovascular Disorders;Cessation of life;Clinical;clopidogrel;cognitive performance;Collagen;Controlled Clinical Trials;Data;diagnostic criteria;differential expression;disability;Double-Blind Method;Early identification;effective therapy;efficacy evaluation;Elderly;experimental study;Financial Hardship;Gene Expression;Grant;health care delivery;Hemorrhage;Image;Impaired cognition;improved;Incidence;Infarction;Intervention;Ischemic Stroke;Knowledge;Lesion;Link;Location;Measures;Mediating;Medical;MicroRNAs;military veteran;multidisciplinary;novel;Patients;Pharmaceutical Preparations;pharmacologic;post stroke;pre-clinical;prevent;Prevention;Prevention strategy;Preventive;Production;Publishing;Quality of life;Randomized;Recurrence;Research;Risk;Risk Assessment;Risk Factors;risk stratification;Role;Societies;Stroke;Stroke prevention;stroke risk;Testing;Thrombin;tool;Transient Ischemic Attack;Translational Research;treatment strategy;Vascular Cognitive Impairment;Veterans

PROJECT_TITLE: Stroke and Coated-Platelets - A Translational Research Initiative


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Digestive Diseases;Digestive Diseases - (Gallbladder);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PI_NAMEs: GULLAPALLI, RAMA  (contact)

PROJECT_TERMS: Address;Animal Model;anti-cancer research;Archives;Arkansas;Automobile Driving;Basic Science;Bile fluid;biliary tract;Biodistribution;Bioinformatics;Biological Assay;Biology;Bolivia;Cadmium;cancer diagnosis;cancer health disparity;Cancer Patient;carcinogenesis;Caucasians;Cell Line;cell motility;Cells;Chelating Agents;Chile;Chilean;Cholelithiasis;Chronic;Clinical;clinical translation;cohort;Collaborations;Country;Data;Demographic Analyses;Disparity;Epithelial Cells;Epithelium;Ethnic Origin;exome sequencing;Exposure to;Functional disorder;Future;Gallbladder;gallbladder carcinogenesis;Gastrointestinal tract structure;Gender;genetic linkage analysis;Geography;Goals;Heavy Metals;Hispanic;hispanic community;Hispanic Populations;Household;Human;Incidence;India;Inductively Coupled Plasma Mass Spectrometry;Inflammation;innovation;Intervention Studies;Libraries;Link;Malignant neoplasm of gallbladder;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;MAP Kinase Gene;MAPK Signaling Pathway Pathway;Mass Spectrum Analysis;Measures;Medicine;Metal exposure;Metals;Mexican;Minority;Modeling;Molecular;Mucous Membrane;Native Americans;New Mexico;novel;Nutritional;Outcome;overexpression;Pathway interactions;Patients;Pattern;Permeability;phosphoproteomics;PIK3CG gene;population based;preventive intervention;Proteomics;Protocols documentation;PTGS2 gene;Research;Risk Factors;Role;Sampling;screening;Seminal;Signal Transduction;socioeconomic disadvantage;Somatic Mutation;Southwestern United States;survival outcome;Survival Rate;Testing;Therapeutic Intervention;Time;Tissues;translational study;United States;Universities;Uranium;wound healing;Zinc

PROJECT_TITLE: Molecular Drivers of Elevated Gallbladder Cancer Incidence in New Mexico


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Pediatric;Rare Diseases

ORG_CITY: CAMBRIDGE

ORG_NAME: ADA FORSYTH INSTITUTE, INC.

PHR: Narrative This proposal investigates the multifaced function of β-catenin in odontogenesis. Using genetically modified mouse strains, we developed new models to elucidate mechanisms underlying tooth morphogenesis mediated by classical and nonclassical signaling of β-catenin. The results obtained are highly relevant to the health of human development because Wnt signaling is causally linked to tooth agenesis and renewal, and understanding the odontogenic potential can facilitate the efficacy of stem cell-based tissue regeneration.

PI_NAMEs: HSU, WEI  (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: Ameloblasts;Amelogenesis;Autologous;AXIN2 gene;beta catenin;Cell Communication;Cells;Characteristics;comparative;Comparative Study;Crowns;Data;Defect;Dental;Dental Enamel;Dental Implants;Dental Pulp;Development;Developmental absence of tooth;differential expression;Disease;Drosophila genus;Epithelium;Evaluation;Gene Expression Profile;Gene Modified;Generations;Genes;Genetic;genetic approach;Genetic Models;Genetic study;Genetic Transcription;genome editing;Germ;Health;Human;Human Development;Human Genetics;Hypodontia;insight;Interruption;Knowledge;knowledge base;Link;loss of function;Maintenance;Mediating;Medicine;Mesenchymal;Mesenchyme;Modeling;Morphogenesis;mouse genetics;mouse model;Mouse Strains;Mus;mutant;Mutant Strains Mice;Mutation;next generation;novel;Odontoblasts;Odontogenesis;Organ Culture Techniques;Pathogenesis;Pathway interactions;permanent tooth;Phenotype;Play;Prosthodontic specialty;Proteins;regenerative;regenerative approach;Regulation;repaired;restorative dentistry;Role;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;stem cells;Supernumerary Tooth;Syndrome;Testing;tissue regeneration;Tissues;Tooth Germ;Tooth regeneration;Tooth structure;transcriptomics;Transforming Growth Factor beta;Transplantation;WNT Signaling Pathway;WNT10A gene

PROJECT_TITLE: Nonclassical β-catenin signaling in odontogenesis

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: EAST LANSING

ORG_NAME: TARN BIOSCIENCES, INC.

ORG_STATE: MI

PHR: The spread of tuberculosis is a global health crisis leading to over one million deaths annually. The global burden of tuberculosis is a threat to the health of all Americans, and directly relevant to the mission of the National Institute of Allergy and Infectious Diseases, given the easy transmission of the disease through the air and the emergence of drug resistant strains that are difficult to treat. Moreover, there exists an increasing population of Americans with enhanced susceptibility to TB due to factors associated with compromised immune systems, including: HIV infection, the use of anti-rejection and anti-inflammatory drugs, as well as natural decreases in immunity associated with an aging population.

PI_NAMEs: VRBANAC, JOHN JAMES (contact)

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: Acute;Adverse drug effect;aging population;Air;American;analog;Anti-Inflammatory Agents;Antibiotics;Antitubercular Antibiotics;aqueous;Bacteria;bactericide;Biological Availability;Biological Sciences;Caring;cell envelope;Cells;Cessation of life;Chemicals;Chemistry;Chronic;chronic infection;clinical development;Combined Modality Therapy;commercial application;Complex;Cord Factors;cost effective;Country;Data;Development;disease transmission;Drug resistance;Drug resistance in tuberculosis;drug-like compound;efficacy study;Evolution;Exhibits;Formulation;Foundations;global health;Glycolipids;Goals;Granulomatous;Growth;Health;HIV Infections;Immune system;Immunity;improved;In Vitro;in vivo;inhibitor;innovation;interest;isoniazid;knock-down;Legal patent;Licensing;Lung;Macrophage;Mediation;Metabolism;Michigan;Microsomes;Mission;Modeling;mouse model;Multidrug-Resistant Tuberculosis;Mus;mutant;Mycobacterium Infections;Mycobacterium smegmatis;Mycobacterium tuberculosis;mycolate;Mycolic Acid;National Institute of Allergy and Infectious Disease;New Agents;non-tuberculosis mycobacteria;novel therapeutics;Oral;Outcome;Pathway interactions;Patient Compliance;Patient Noncompliance;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Phenotype;pill;Pilot Projects;Plasma;Population;preclinical development;Predisposition;Property;Regimen;Resistance;resistant strain;safety study;scaffold;Series;Small Business Technology Transfer Research;small molecule;Solubility;standard of care;Structure-Activity Relationship;therapeutic target;treatment duration;Trehalose;Tuberculosis;tuberculosis drugs;tuberculosis treatment;Universities;Work

PROJECT_TITLE: Development of the HC2099 series of MmpL3 inhibitors to treat tuberculosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-F(12)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Narrative Cell fate programs are initiated by ‘pioneer factors’ that recognize their genomic target sites within the context of nucleosomes and induce gene regulatory programs. We will develop technologies to investigate the influence of genomic sequence features and histone marks on the interactions of human pioneer factors with nucleosomes.

PI_NAMEs: BULYK, MARTHA L (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Affect;Binding;Binding Sites;Biochemical;Biological Assay;Breathing;Cell Differentiation process;cell type;Cells;ChIP-seq;Chromatin;cofactor;Computer Analysis;Data;DNA;DNA Binding;DNA Binding Domain;DNA Sequence;Elements;Epigenetic Process;Etiology;Eukaryota;Family;Gatekeeping;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genets;Genome;genomic data;Genomics;Heterochromatin;high throughput screening;high throughput technology;Histone H2A;histone modification;Histones;Human;In Vitro;in vivo;in vivo evaluation;Invaded;Manuscripts;molecular modeling;novel;Nuclear;Nucleic Acid Regulatory Sequences;Nucleosomes;Periodicity;Play;Positioning Attribute;Post-Translational Protein Processing;preference;Preparation;programs;Property;Reader;reconstitution;recruit;Regulator Genes;Regulatory Element;Role;Site;Slide;Specificity;Surveys;Technology;transcription factor;Variant

PROJECT_TITLE: Influences of DNA sequence and histone features on transcription factor binding to nucleosomes

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Hematology;Human Genome;Immunotherapy;Infectious Diseases;Lymphatic Research;Lymphoma;Malaria;Pediatric;Pediatric Cancer;Rare Diseases;Vector-Borne Diseases

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: This proposal focuses on understanding the role of malaria in diminishing T cell immunity to Epstein-Barr Virus in children. These two infections interact to increase the risk of endemic Burkitt lymphoma, which is the most common childhood cancer in Equatorial Africa. Results from this study will help us understand how to prevent this cancer and to design better treatments to improve survival for these children.

PI_NAMEs: MOORMANN, ANN M (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: 1 year old;6 year old;9 year old;Activities of Daily Living;Acute;Adult;Africa;African;African Burkitt's lymphoma;Antigens;Area;B-Lymphocytes;Biological Assay;Blood;Burkitt Lymphoma;cancer cell;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Line;Cell Physiology;Cells;Child;Childhood;Chronic;chronic infection;co-infection;Coculture Techniques;cohort;CTLA4 gene;cytokine;Cytotoxic T-Lymphocytes;cytotoxicity;density;design;Development;Diagnosis;EBV specific T-cells;effector T cell;Enrollment;Environment;Epstein-Barr Virus Infections;Epstein-Barr Virus-Related Malignant Neoplasm;Etiology;exhaustion;experience;experimental study;Exposure to;Falciparum Malaria;Family member;Fever;Flow Cytometry;FOXP3 gene;Frequencies;Granzyme;Herpesviridae Infections;Heterogeneity;Homeostasis;Human;Human Herpesvirus 4;IL2RA gene;Immune;Immunity;Immunocompetent;Immunologic Surveillance;Immunologics;immunopathology;immunoregulation;Impairment;improved;In Vitro;in vitro testing;Individual;infected B cell;Infection;Inflammatory;Interferon Type II;interleukin 20;Interleukin-10;interleukin-19;interleukin-22;Interleukin-24;Intervention;Lead;Ligands;Link;lymphoblastoid cell line;Malaria;malaria infection;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;Mediating;Mediator;Memory;Mus;Natural Killer Cells;OX40;Parasites;Pathogenesis;Pathologic;Pathway interactions;Patients;permissiveness;Plasmodium falciparum;prevent;programmed cell death protein 1;receptor;receptor expression;Recording of previous events;Regulatory T-Lymphocyte;restraint;Risk;Role;Schedule;Shapes;Signal Transduction;single-cell RNA sequencing;Site;T cell response;T memory cell;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Time;transcriptome sequencing;transforming virus;tumor;tumorigenesis;Viral;Viral load measurement;Virus Replication;Visit;γδ T cells

PROJECT_TITLE: Impact of malaria on shaping immunity to EBV in the etiology of Burkitt lymphoma

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Mental Health;Pediatric;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: AUSTIN

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE Throughout the developing world, health disparities begin at birth, in part because social discrimination and family contexts influence the health of pregnancy. In this mentored training project, PI Diane Coffey will be trained in the use of biomarkers and in the biology of stress as it relates to pregnancy. Such training will empower a research agenda that uses demographic data to explain inequalities in lifelong wellness as resulting, in part, from social and family structures that are embodied in biologically-measurable dimensions of healthy pregnancy.

PI_NAMEs: COFFEY, DIANE  (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Affect;Anthropometry;Asia;Attention;Biochemical;Biological;Biological Markers;Biological Models;Biological Process;Biology;Biometry;Biosocial;Birth;Blood Pressure;burden of illness;career;Child;Child Development;Clinical;Complement;Corwin;Country;Data;Data Analyses;Data Set;Data Sources;Demography;Developing Countries;Dimensions;Disadvantaged;Discrimination;Doctor of Philosophy;econometrics;Economic Development;Economics;Educational workshop;empowerment;evidence base;experience;Family;Family dynamics;family structure;Foundations;Future;Generations;Glucose;Health;health assessment;health disparity;Health Surveys;healthy pregnancy;Hemoglobin;Household;Human Development;Hydrocortisone;Hypertension;India;Inequality;International;Life;maternal stress;Measurable;Measurement;medical schools;Mentors;Mentorship;Methods;migration;Modeling;Mothers;National Institute of Child Health and Human Development;Needs Assessment;Neonatal Mortality;Nuclear;Nuptiality;Obesity;Outcome;Pattern;Physiology;Population;Population Sciences;Population Study;Positioning Attribute;Pregnancy;pregnant;Pregnant Women;Process;programs;Public Health;Reading;Research;residence;Risk Factors;Rural;Scientist;Sex Discrimination;Site;skills;social;Social Change;Social Discrimination;Social status;social structure;Social support;Societies;Stress;Structure;Surveys;symposium;theories;Training;training project;Universities;Urbanization;Woman;Women's study

PROJECT_TITLE: Family dynamics, maternal stress, and the biomarkers of healthy pregnancy

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


NIH_SPENDING_CATS: Natural Products

ORG_CITY: AMES

ORG_DEPT: CHEMISTRY

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: Single atom changes are often used in the pharmaceutical industry to modulate the biological properties of a small molecule, but the introduction of such changes require time-consuming re-designing of synthesis routes. The proposed research will lead to the development of new catalysts and reaction sequences that directly modify the core of molecules relevant to human health.

PI_NAMEs: LI, JUNQI  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Atom-swapping reaction sequences enabled by decarbonylation and decarboxylation


ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: NARRATIVE. Genetic mitochondrial respiratory chain diseases result in severe disease, affecting nearly every organ system, including brain, heart, liver and eyes. Diagnosing primary respiratory chain deficiency is difficult, especially in the subset of diseases that affect Complex V (ATP Synthase; CV), the primary source of cellular energy. This work seeks to understand how CV deficiency affects cellular function both in resting cells and cells undergoing metabolic stress, providing a potential avenue for future diagnostic & treatment approaches.

PI_NAMEs: GANETZKY, REBECCA  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Affect;alpha ketoglutarate;Ataxia;ATP Synthesis Pathway;Biochemical;Biological Assay;Body System;Brain;Candidate Disease Gene;Cardiomyopathies;Cell Line;Cell model;Cell Physiology;Cells;Cellular Stress;Classification;Clinical;clinical diagnostics;clinical predictors;clinically significant;Crista ampullaris;Defect;Diagnosis;Diagnostic;diagnostic assay;Disease;Electron Transport;Enzymes;Exposure to;Eye;Fibroblasts;Foundations;Functional disorder;Future;Galactose;Genes;Genetic;genetic variant;Genetic Variation;Glucose;Goals;Heart;Human;Interphase Cell;Lipopolysaccharides;Liver;Membrane Potentials;Metabolic;Metabolic stress;Mitochondria;mitochondrial membrane;Mitochondrial Respiratory Chain Deficiencies;Modeling;Morphology;Mutation;Neuropathy;novel;Nutrient;Nutritional;oligomycin sensitivity-conferring protein;Oxygen Consumption;Pathogenicity;Phenotype;Physiological;prevent;Procedures;Prognosis;Proton-Motive Force;Protons;research clinical testing;Respiratory Chain;Response to stimulus physiology;Retinal Diseases;Series;Severities;Source;Stroke;Structure;Symptoms;System;Testing;Therapeutic;treatment response;Variant;variant of unknown significance;Work

PROJECT_TITLE: Biochemical and Physiological Phenotypes of CV Dysfunction In Human Cell Models

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-L(55)R]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: OVERALL: PUBLIC HEALTH NARRATIVE  American Indians, Alaska Natives, Native Hawaiians, and Pacific Islanders are increasingly concerned about Alzheimer’s disease, dementia, and cognitive impairment. These conditions will soon have a major impact on their communities because the life expectancies for these groups have improved over the last 50 years by as much as 30 years, resulting in a large increase in the number of older adults. Unfortunately, the healthcare systems that serve these populations are unprepared for the clinical, economic, and social burdens associated with Alzheimer’s disease, dementia, and cognitive impairment. Our goal is to reduce disparities related to these conditions by testing various sustainable and culturally-appropriate interventions. The leadership, resources, and experience of our team can help address the National Institute on Aging’s research priorities for underrepresented minorities and respond to its interest in diversifying the scientific workforce.

PI_NAMEs: GALVIN, JAMES E;KAUWE, JOHN SAI KEONG;MCPHERSON, STERLING M (contact)

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: Address;Adherence;Alaska Native;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;American Indians;Area;Articulation;Awareness;Behavior Therapy;Behavioral Sciences;Blood specimen;Cataloging;Catalogs;Cholesterol;Clinic;Clinical;Clinical Sciences;cognitive function;cohort;Collection;Communities;Community Healthcare;community partners;community partnership;culturally appropriate intervention;Data;Dementia;dementia risk;demographics;Detection;Disparity;disparity elimination;disparity reduction;DNA;Economic Burden;Economics;effective intervention;effectiveness testing;Elderly;Ensure;experience;Family;Frequencies;Friends;Genetic Markers;Genetic Research;genetic risk factor;Genotype;Goals;Hawaii;Hawaiian;Health;Health Benefit;health disparity;Healthcare Systems;High Prevalence;high risk;human old age (65+);Hypertension;Impaired cognition;improved;Indian reservation;innovation;interest;Intervention;Island;Knowledge;Leadership;Life Expectancy;low socioeconomic status;mild cognitive impairment;Minnesota;National Institute on Aging;native elder;Native Hawaiian;Native Hawaiian or Other Pacific Islander;Native-Born;natives;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Observational Study;Obstructive Sleep Apnea;older adult;Persons;Physical activity;polygenic risk score;Population;preservation;prevent;programs;Provider;Public Health;public health research;Quality of life;randomized trial;Randomized, Controlled Trials;recruit;repository;Research;Research Methodology;Research Personnel;Research Priority;Research Project Grants;Resources;rural health clinic;Saliva;saliva sample;Sampling;Satellite Centers;Sleep Apnea Syndromes;Smoking;social;Social Sciences;Special Population;Testing;Training;Translating;tribal community;Underrepresented Minority;Universities;Washington;Work

PROJECT_TITLE: Natives Engaged in Alzheimer's Research


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

PI_NAMEs: BUCHWALD, DEDRA S (contact)

PROJECT_TERMS: Advisory Committees;Alaska Native;Alzheimer's Disease;Alzheimer's disease related dementia;American Indians;Appointment;Articulation;Biology;brain health;Budgets;Businesses;career development;Clinical Trials Data Monitoring Committees;Collaborations;Collection;college;Communication;Communities;Community Actions;community based participatory approach;community organizations;Computers;data sharing;Doctor of Philosophy;Education;Ensure;Evaluation;experience;Faculty;Genetic;Goals;Hawaii;Health;Health care facility;health disparity;Human Resources;implementation facilitation;Institution;Institutional Review Boards;International;Leadership;Medicine;meetings;Mental Health;Minnesota;Minority Groups;Mission;Monitor;National Institute on Aging;Native Hawaiian;Native Hawaiian or Other Pacific Islander;natives;Neurology;operation;Oral;outreach;Pacific Islander;physical conditioning;Policies;Population Research;Preparation;Principal Investigator;Process;professor;programs;Publications;recruit;Regulation;Research;Research Activity;Research Methodology;Research Personnel;Research Project Grants;Research Support;Rural;Satellite Centers;Scholarship;Scientist;Site;Specialist;Travel;Tribes;Underrepresented Minority;Underrepresented Populations;Underserved Population;Universities;urban Native American;Washington;Work;Writing

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are two fatal and incurable neurodegenerative diseases linked by a shared genetic cause – a heterozygous hexanucleotide (GGGGCC) repeat expansion in a single allele of the C9orf72 gene. The goal of this work is to develop novel CRISPR based therapeutic gene editing technologies and test whether gene editing can reverse the cellular pathology caused by this repeat expansion in patient derived cells. The results of these studies will advance our use of CRISPR technologies for therapeutic editing in FTD/ALS, inform our understanding of the regulation of C9orf72 gene, and will be applicable to many other repeat expansion and single gene disorders.

PI_NAMEs: CLELLAND, CLAIRE  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Address;Alleles;ALS patients;Area;Autopsy;Award;Bioinformatics;Biological Sciences;Brain;c9FTD/ALS;C9ORF72;career;Cell Line;Cell model;Cell Physiology;Cell Survival;cell type;Cells;cellular pathology;Clinical;clinical training;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communication;CRISPR therapeutics;CRISPR/Cas technology;curative treatments;Dementia;design;Disease;disease model;DNA;DNA sequencing;effective therapy;Elements;Engineering;Environment;Equipment;Exons;experience;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Funding;gene editing technology;Gene Expression;Gene Expression Regulation;Gene Silencing;gene-editing approach;Genes;Genetic;Genetic Transcription;genome analysis;Genomics;Goals;Guide RNA;Heritability;Heterozygote;human disease;human induced pluripotent stem cells;human tissue;Individual;induced pluripotent stem cell;innovation;K-Series Research Career Programs;Knowledge;Link;Measures;Mendelian disorder;Mentors;Mentorship;Methods;Microglia;Modeling;Molecular;Motor Neurons;mutant;Mutation;mutation carrier;Neurodegenerative Disorders;Neuroglia;Neurons;novel;novel therapeutic intervention;novel therapeutics;Pathogenicity;Pathologic;Pathology;patient derived induced pluripotent stem cells;Patients;Phase;promoter;Regulation;Research;Research Personnel;Research Training;Role;Running;Scientist;single molecule;skills;Specificity;Spinal Cord;Technical Expertise;Technology;Testing;Therapeutic;therapeutic genome editing;Tissues;tool;Training;Transcription Initiation Site;whole genome;Work

PROJECT_TITLE: CRISPR-Cas9 editing in C9orf72 patient derived iPSC

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE Osteosarcoma is an aggressive pediatric solid malignancy that remains difficult to cure even with intensive chemotherapy and surgery. In this study, blood samples from patients with osteosarcoma will be used to profile circulating tumor DNA and circulating osteosarcoma cells to identify genomic features that are associated with a high-risk of treatment failure. Results from this study will enable the development of new risk-based and personalized treatment strategies for patients with osteosarcoma.

PI_NAMEs: CROMPTON, BRIAN  (contact)

PROGRAM_OFFICER_NAME: DEY, SUMANA MUKHERJEE

PROJECT_TERMS: Address;Adult;Anesthesia procedures;Biological Assay;Biology;biomarker development;Biopsy;Biopsy Specimen;Blood;Blood specimen;bone;burden of illness;Cancer Patient;cell free DNA;Cells;chemotherapy;Child;Childhood;Clinical;cohort;Collecting Cell;Collection;Complex;Correlation Studies;Decalcification;deep sequencing;Detection;Development;Diagnosis;Disease;disease natural history;Disease Surveillance;Event;Evolution;Exclusion;Future;Genome;genome sequencing;Genomic Instability;Genomics;Goals;Hematopoietic Neoplasms;Heterogeneity;high risk;improved;Individual;individualized medicine;liquid biopsy;Localized Disease;Malignant Neoplasms;Measurement;mortality;Neoplasm Circulating Cells;neoplastic cell;Newly Diagnosed;next generation sequencing;novel;novel marker;Operative Surgical Procedures;Osteosarcoma;Outcome;Patients;Pattern;peripheral blood;personalized medicine;Plasma;Population;prevent;Prognosis;prognostic;Prognostic Marker;Prospective cohort;Recurrence;Recurrent disease;Relapse;Research;Resistance;response;Retrospective cohort;Risk;risk stratification;Safety;Sampling;single cell sequencing;Solid;Source;standard care;surveillance strategy;Techniques;Technology;Testing;Therapeutic;therapy resistant;Time;tissue biomarkers;Tissues;Treatment Failure;treatment strategy;tumor;tumor DNA;tumor heterogeneity;Variant;whole genome;young adult

PROJECT_TITLE: Liquid biopsy approaches to inform osteosarcoma prognosis and tumor evolution

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Emergency Care;Health Services;Mental Health;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW YORK

ORG_NAME: NDRI-USA, INC.

PHR: Project Narrative A national sample of emergency medical service (EMS) providers will provide a qualitative and quantitative look into the use of alcohol by EMS providers and its role in occupational culture. Associations between alcohol use and occupational, physical, and mental health outcomes will be explored. Understanding the culture of alcohol in EMS is key to the development of programs and interventions aimed at increasing the health and wellness of this vulnerable occupational group of first responders.

PI_NAMEs: KOEPPEL, MARIA  (contact)

PROGRAM_OFFICER_NAME: CASTLE, I-JEN

PROJECT_TERMS: Accidental Injury;Accidents;Address;Adverse effects;adverse outcome;Alcohol abuse;alcohol behavior;Alcohol consumption;alcohol effect;alcohol expectancy;alcohol misuse;Alcohols;Anxiety;Attention;Attitude;binge drinking;Caring;cohesion;Communicable Diseases;Data Set;Development;drinking;drinking behavior;Driving While Intoxicated;DSM-V;Emergency medical service;Emergency Medical Technicians;Employment Status;Evaluation;experience;fire fighter;first responder;fitness;General Population;Health;Health protection;Heavy Drinking;Human Resources;Impairment;Injury;insight;Intervention;Interview;Knowledge;Law Enforcement;Law Enforcement Officers;Liver diseases;Medical;Mental Depression;Mental Health;Methods;military service;musculoskeletal injury;Neurologic;Obesity;Occupational;Occupational Groups;Occupational Health;Occupational injury;Occupations;Outcome;Overweight;pandemic disease;Paramedical Personnel;physical conditioning;physical inactivity;Police officer;Policies;poor sleep;Population;Post-Traumatic Stress Disorders;Prevalence;Principal Investigator;Probability;professional atmosphere;Program Development;prospective;Provider;Random Allocation;Reporting;Research;response;Risk;Risk Factors;Role;Safety;safety net;Sampling;service organization;service providers;Sleep;Sleep Disorders;sociodemographics;Stress;Symptoms;System;Transportation of Patients;Trauma;trauma exposure;Violence;Wellness Program;Work;Workplace

PROJECT_TITLE: Looking through the bottle: Exploring alcohol use among emergency medical service providers

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: MULLER, CLEMMA JACOBSEN (contact)

PROJECT_TERMS: Aging;Alaska Native;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease risk;American Indians;Behavior Therapy;Behavioral Research;Biometry;Chippewa;Clinical;Clinical Trials;Collaborations;college;Communities;Community Health;community partners;community setting;Data;Data Analytics;Data Collection;database design;design;Diagnosis;Disease;Disparity;Education;Ensure;Epidemiologist;Epidemiology;ethnic health disparity;Ethnic Population;Evaluation;evidence base;experience;Faculty;flexibility;Funding;genetic epidemiology;Goals;Grant;Health;Health behavior;health inequalities;Health Personnel;Health Status;Healthcare;Healthy People 2020;High Prevalence;Hypertension;improved;Indigenous;Individual;Infrastructure;innovation;instrument;Intervention Studies;Intervention Trial;Life Expectancy;Life Style;low socioeconomic status;Measurable;Measurement;Measures;Medicine;member;Methodology;Methods;mid-career faculty;mild cognitive impairment;Minnesota;Minority;Native Hawaiian or Other Pacific Islander;Native-Born;natives;Non-Insulin-Dependent Diabetes Mellitus;Persons;Physical activity;Play;Policies;Policy Maker;Population;Prevalence;Prevention;professor;Public Health;Qualitative Research;racial disparity;racial population;randomized trial;Reproducibility;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Resource Allocation;Resources;Risk;Role;Sample Size;Sampling;Science;Services;skills;Sleep Disorders;Smoking;social;Standardization;Statistical Data Interpretation;Training;Trust;United States National Institutes of Health;Universities;Validity and Reliability;Washington;Work

PROJECT_TITLE: Research Methods Core


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Experience-dependent adjustments of brain function, as it happens during learning and memory, critically rely on activity-dependent modifications of neural circuits that mainly occur at synapses. Alterations of this process is thought to underlie several brain diseases such as autism, epilepsy and major psychiatric disorders. The proposed studies seek to demonstrate a role for local protein synthesis in activity-dependent remodeling of the presynaptic compartment and long-term changes in neurotransmitter release.

PI_NAMEs: CASTILLO, PABLO E (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Actins;Affinity;autism spectrum disorder;Axon;Biological Models;Brain;Brain Diseases;Brain-Derived Neurotrophic Factor;Cognition Disorders;Cytoskeleton;Data;Dendrites;Dendritic Spines;Developmental Disabilities;disability;Drug Addiction;Epilepsy;Excitatory Synapse;experience;FMR1 gene;Functional disorder;functional plasticity;Hippocampus;Inherited;Inhibitory Synapse;insight;Intellectual functioning disability;Learning;Long-Term Depression;Long-Term Potentiation;loss of function mutation;Mediating;Memory;Mental disorders;Messenger RNA;Modification;Molecular;Mood Disorders;Mutation;neural circuit;neuropsychiatry;neurotransmission;neurotransmitter release;Pathway interactions;Phosphotransferases;postsynaptic;presynaptic;presynaptic neurons;Presynaptic Terminals;Process;Property;Protein Biosynthesis;Proteins;Proteome;Proteomics;receptor;Receptor Protein-Tyrosine Kinases;release factor;response;RNA;RNA-Binding Proteins;Rodent;Role;Schizophrenia;Signal Transduction;Site;Structural defect;Structure;Synapses;Synaptic plasticity;Testing;Transcript;Translation Initiation;Translational Repression;Translations;Tropomyosin;Visualization

PROJECT_TITLE: Presynaptic forms of long-term plasticity in the CNS

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Arctic;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

PI_NAMEs: SINCLAIR, KA'IMI ALOHILANI (contact)

PROJECT_TERMS: Address;aged;Alaska Native;Alaska Native population;Alzheimer's Disease;Alzheimer's disease related dementia;American Indians;Arizona;Articulation;Award;Awareness;Brain;career;Collaborations;Collection;Communities;community engagement;Community Participation;community partners;community research;Community Services;Congresses;Data;Data Collection;design;Disparity population;Disputes;Education;Educational workshop;Employment;Ensure;Equity;expectation;Future;General Population;Genetic Research;Goals;Havasupai;Health;health disparity populations;Hostility;human old age (65+);informant;Information Dissemination;innovation;Institution;Institutional Review Boards;instrument;interest;Intervention;Interviewer;Knowledge;Life Expectancy;Litigation;Mass Media;meetings;member;Methods;Modeling;Monitor;National Institute on Aging;native elder;Native Hawaiian or Other Pacific Islander;Native-Born;natives;neglect;novel;Outcome;outreach;Ownership;participant retention;Perception;Persons;Population;Positioning Attribute;programs;Readiness;Recommendation;recruit;Registries;Remunerations;Reporting;Research;research data dissemination;Research Personnel;Research Project Grants;research study;Resolution;Resources;Satellite Centers;Site;skill acquisition;Stigmatization;Surveys;Tissue Sample;Training;tribal member;Tribes;United States National Institutes of Health;Universities;webinar;Work

PROJECT_TITLE: Recruitment and Engagement Core


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: The Vanderbilt Nephrology Training Program provides a structured and mentored training experience in basic and clinical and translational research for selected MD and PhD post-doctoral trainees. The goal of this program is to provide the training necessary to develop into an independent researcher in kidney-related research.

PI_NAMEs: HARRIS, RAYMOND C. (contact);IKIZLER, TALAT ALP

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TITLE: Renal Biology and Disease Training Program


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: DENTISTRY

PHR: Project Narrative Dental decay and tooth loss constitute an important public health issue. Stem cells in continuously growing dental tissues provide an excellent model for deciphering mechanisms that enable repair and regeneration of teeth, as well as other organs. This proposal will use state-of-the-art approaches to study how dental stem cells in the mouse incisor differentiate into enamel-producing ameloblasts, which will lay the long-term groundwork for clinical applications of stem cell biology in human dentition.

PI_NAMEs: SUNG, DAVID  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Ablation;Adult;Affect;Ameloblasts;Apoptosis;Behavior;Bromodeoxyuridine;California;career;Catalytic Domain;Cell Differentiation process;cell growth regulation;Cells;Chromatin;chromatin modification;Chromatin Remodeling Factor;Cleavage Under Targets and Release Using Nuclease;clinical application;clinical training;Complex;Dental;Dental caries;Dental Enamel;Dental Schools;Dentists;Dentition;Deposition;design;Development;Enhancers;Environment;Epithelial Cells;epithelial stem cell;Epithelium;Equilibrium;Fluorescence-Activated Cell Sorting;Fluorouracil;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic Transcription;Growth;Histones;Homeostasis;Homologous Gene;Human;Immunofluorescence Immunologic;Incisor;Injury;Journals;Kinetics;Label;Laboratories;Lysine;Mediating;meetings;Mentorship;Methylation;Modeling;Mus;mutant;Natural regeneration;Organ;Pattern;Polycomb;Population;preservation;progenitor;Proliferating;promoter;protein expression;Proteins;Public Health;Qualifying;Regulation;repaired;Repression;Research;Role;San Francisco;Scientist;self-renewal;single cell ATAC-seq;Stains;stem cell biology;stem cell differentiation;stem cell fate;stem cell self renewal;stem cells;Structure;symposium;System;TdT-Mediated dUTP Nick End Labeling Assay;Technology;Testing;Tissues;Tooth Loss;Tooth regeneration;Tooth structure;Training;Universities;Wild Type Mouse

PROJECT_TITLE: Chromatin modifier Polycomb Repressive Complex 2 as a regulator of dental epithelial progenitor cells

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Estrogen;Genetics;Liver Disease;Substance Misuse;Women's Health Research

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

PHR: PROJECT NARRATIVE Title: Human pregnane X receptor and sexual dimorphism in alcoholic liver disease. Alcoholic liver disease (ALD) is a disease that disproportionately affect women and African Americans (AAs). We have shown that the nuclear receptor pregnane X receptor (PXR) in mice promotes the development of ALD. Unexpectedly, we found that alcohol produced a more severe liver injury in female mice which carry the human PXR gene than female wild type mice. This study will use humanized animal models and human liver and blood samples of both sexes to provide important new insights into the mechanisms by which the human PXR gene promotes in ALD, especially in women and treatment options for ALD.

PI_NAMEs: GYAMFI, MAXWELL AFARI (contact)

PROGRAM_OFFICER_NAME: PERRUCCIO, ELIZABETH M

PROJECT_TERMS: Acetaldehyde;Address;African American population;Alcohol consumption;alcohol exposure;Alcoholic Liver Diseases;Alcoholic steatohepatitis;Alcohols;Alleles;Animal Model;AODR mortality;Apoptosis;Biological Assay;Blood;Blood specimen;Caucasians;Cell Death Induction;Cells;Chemicals;Chronic;Clinical Research;clinically relevant;constitutive androstane receptor;Data;Death Rate;Development;diagnostic biomarker;Disease;disorder risk;Disproportionately impacts women;DNA Fragmentation;DNA Library;Dose;Drug Kinetics;Drug Metabolic Detoxication;Estrogens;Ethanol;Ethanol Metabolism;ethnic difference;Fatty acid glycerol esters;feeding;Female;Gene Expression;Gene Expression Profile;Gene Frequency;Generations;Genes;Genetic Polymorphism;Genetic Transcription;Genomic DNA;Genotype;Hepatic;Hepatocyte;Hepatotoxicity;Homologous Gene;Human;human tissue;humanized mouse;insight;Intervention;Intestines;Knockout Mice;lipid biosynthesis;Lipids;Liver;liver injury;male;Mediating;men;Messenger RNA;Metabolic;Metabolic Diseases;metabolomics;Modeling;mouse model;Mus;novel;novel diagnostics;Nuclear;Nuclear Receptors;Orthologous Gene;Pathogenesis;Pathologic;Pathology;Patients;Pharmaceutical Preparations;pharmacologic;PPAR gamma;pregnane X receptor;problem drinker;Production;Proteins;Reactive Oxygen Species;receptor;Receptor Gene;Receptor Signaling;Regulation;Reporting;Rodent;Role;sex;Sex Differences;sexual dimorphism;Signal Transduction;Single Nucleotide Polymorphism;small hairpin RNA;specific biomarkers;Testing;therapeutic target;Tissues;transcription factor;Up-Regulation;Variant;Wild Type Mouse;Woman;Xenobiotics

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]