NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Heart Disease - Coronary Heart Disease;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Narrative: This proposal will study how social determinants of health, including measures of structural racism, affect coro- nary heart disease and heart failure outcomes. An interdisciplinary group of accomplished investigators will conduct studies of incident and recurrent heart disease, designed specifically to inform policies. We will provide rigorous adjudicated data and Medicare data for investigators outside our study group and provide mentorship to young investigators building careers in health equity research.

PI_NAMEs: LEVITAN, EMILY B;SAFFORD, MONIKA M (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: acute stress;adjudication;Adult;Advocacy;Affect;aged;Aging;American Heart Association;Ancillary Study;Area;Behavioral;Biological Markers;Black race;Cardiovascular Diseases;career;career development;Cause of Death;Centers for Disease Control and Prevention (U.S.);Childhood;cohort;Communities;Competence;Coronary heart disease;Data;Dedications;design;Development;Disparity;EFRAC;Enrollment;Epidemiologist;Event;Foundations;Funding;Future;Genetic;geographic disparity;Goals;Grant;Health;Health Campaign;Health Disparities Research;health disparity;health equity;Health equity research;health service use;Health Services;Heart;Heart Diseases;Heart failure;heart failure with reduced ejection fraction;Hospitalization;Incidence;Infrastructure;interest;Lead;Life;Life Cycle Stages;Link;Measures;Medicare;Mentors;Mentorship;multidisciplinary;Myocardial Infarction;National Heart, Lung, and Blood Institute;novel;Outcome;Participant;patient oriented;Patient Self-Report;Patient-Focused Outcomes;Peer Review;Policies;Policy Making;Population;preservation;Professional Organizations;Program Development;programs;Public Health;Publications;Publishing;racial disparity;Reasons for Geographic And Racial Differences in Stroke;Recovery;Recurrence;Reporting;Research;Research Personnel;resilience;Risk;Role;Sampling;Series;social health determinants;social influence;sociologist;Strategic vision;Stroke;Structural Racism;Study Section;summer institute;therapy design;Training;training opportunity;Underrepresented Minority;United States National Academy of Sciences;US State;Work;World Health Organization

PROJECT_TITLE: REasons for Geographic And Racial Differences in Stroke-Myocardial Infarction-4 (REGARDS-MI-4)

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Coronaviruses;Infectious Diseases

ORG_CITY: MAYWOOD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The assembly and egress of coronaviruses is controlled by peptide motifs that are found on the cytoplasmic extensions of virion membrane proteins. These peptide motifs interact with host machineries directing intracellular protein and vesicle transport. Here we will construct recombinant coronaviruses and virus‐like particles containing alternative peptide motifs, with comparative analyses aimed at discerning the mechanisms by which coronaviruses incorporate membrane proteins and then transport out of infected cells.

PI_NAMEs: GALLAGHER, THOMAS MILLER (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: Affect;Anti-viral Agents;Binding;Biochemical;Cell membrane;Cell surface;Cells;Cellular Structures;Coat Protein Complex I;Code;Communication;comparative;Complex;Coronavirus;Coronavirus Infections;COVID-19 vaccine;Cytoplasm;Cytoplasmic Tail;Data;E protein;Endoplasmic Reticulum;Endosomes;Foundations;Goals;Human;improved;Infection;Integration Host Factors;intracellular protein transport;knockout gene;Knowledge;Laboratories;Membrane;Membrane Proteins;Methods;Molecular Chaperones;Mus;novel coronavirus;Organelles;particle;Pathogenicity;Pathway interactions;Peptides;pharmacologic;Process;protein transport;Proteins;recombinant virus;Recombinants;Recycling;Research;Site;sorting nexins;System;trafficking;Vesicle;vesicle transport;Viral;Viral Matrix Proteins;Viral Proteins;Virion;Virus;Virus Diseases;virus host interaction;Virus-like particle

PROJECT_TITLE: Dissecting the peptide motifs controlling coronavirus infections


ADMINISTERING_IC: DK

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative One major reason for the current obesity epidemic and its associated lack of effective treatment is due to incomplete understanding of neuronal control of complex feeding behavior. Using a combination of fiber photometry and mouse genetic approaches, the current proposal will determine whether paraventricular hypothalamic corticortropin-releasing hormone (CRH) neuron responsiveness functions as a neural basis underlying diet-induced obesity and time-restricted feeding or clock-enhancement inducing obesity prevention. The results will identify a previously unknown neural basis that dictates metabolic outcomes in response to diet changes and therefore form a foundation for effective treatments against obesity.

PI_NAMEs: TONG, QINGCHUN  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Ablation;Adrenal Cortex Hormones;Adrenal Glands;Adult;Anxiety;Behavioral;biological adaptation to stress;Black race;Blood;Body Weight;Body Weight Changes;Body Weight decreased;Brain;Chronic stress;Circadian Rhythms;Closure by clamp;Code;Color;Complex;Consumption;Corticotropin-Releasing Hormone;design;Development;Diet;diet-induced obesity;Diurnal Rhythm;Economic Development;effective therapy;Energy Metabolism;experimental study;Fatty acid glycerol esters;Feedback;feeding;Feeding behaviors;Fiber;fighting;Food;Foundations;Functional disorder;GABA Receptor;genetic approach;Glutamate Receptor;Glutamates;Goals;High Fat Diet;Homeostasis;Hormonal;Hormone Responsive;Hormones;Human;Hypothalamic structure;improved;Intake;Knowledge;Lead;Mediating;Metabolic;Metabolism;mouse genetics;Mus;neural;Neural Pathways;neuronal excitability;Neurons;neurotransmitter release;Neurotransmitters;nobiletin;Obesity;obesity development;Obesity Epidemic;obesity prevention;obesity treatment;Outcome;Pattern;Periodicity;Pharmaceutical Preparations;Pharmacological Treatment;Photometry;Pituitary Gland;Positioning Attribute;postsynaptic;Prevention;Reducing diet;Regimen;Regulation;Research;response;Rewards;Rodent;Role;side effect;Signal Transduction;Site;Stress;stressor;Synapses;Testing;Therapeutic;therapeutic development;Time-restricted feeding;Weight maintenance regimen

PROJECT_TITLE: Hypothalamic CRH Neurons in Diet-induced Obesity

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Neurosciences;Nutrition;Obesity;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Eating and drinking are controlled by neural mechanisms in the brain that remain poorly understood. A better understanding of the structure and regulation of the underlying neural circuits would advance our ability to develop new therapeutic approaches for the treatment of medical conditions such as obesity and eating disorders. This proposal utilizes state-of-the-art approaches to selectively manipulate and record the activity of key neurons in the mammalian brain that influence eating and drinking.

PI_NAMEs: BERKE, JOSHUA D;KNIGHT, ZACHARY A. (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Animal Feed;Animals;awake;Behavior;Behavior Control;Behavioral;Brain;Cells;Communication;Conditioned Reflex;conditioning;Consumption;Cues;Data;Dedications;Detection;detection of nutrient;Dopamine;dopamine system;dopaminergic neuron;drinking;Eating;Eating Disorders;Educational process of instructing;Electrophysiology (science);energy balance;experience;experimental study;Fluid Balance;Food;Goals;Homeostasis;Hunger;Hypothalamic structure;Image;in vivo calcium imaging;individual response;Infusion procedures;Ingestion;insight;Lateral;learned behavior;Learning;Link;Liquid substance;Maps;Measures;Mediating;Medical;Midbrain structure;Modeling;Monitor;motivated behavior;Motivation;Mus;neural;neural circuit;neuromechanism;Neurons;novel therapeutic intervention;Nutrient;Nutritional;Obesity;Optics;Pathway interactions;Physiological;Play;Process;Prosencephalon;Regulation;response;Rewards;Role;Signal Transduction;Stimulus;Stomach;Structure;System;Taste Perception;Testing;Thirst;Time;Water

PROJECT_TITLE: Neural mechanisms linking need to reward


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE Parkinson’s disease, the second most common cause of age-related neurodegeneration in the U.S., in part reflects abnormal mitochondrial function in midbrain neurons, which produces cell death. Current therapies relieve the hallmark symptoms of abnormal movements, but they do not prevent neurodegeneration, disease progression, dementia, or death. This proposal will explore the novel hypotheses that there is a previously unrecognized link between hormones secreted by the intestine and midbrain neurons that protects their mitochondria against toxic injury, and that those hormones can be used as drugs to prevent and treat Parkinson’s disease.

PI_NAMEs: CHESLOW, LARA  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: 1-Methyl-4-phenylpyridinium;Abbreviations;age related neurodegeneration;Apoptosis;Autoimmunity;Body Weight;Brain;Cell Death;Cell Nucleus;Cessation of life;Chronic;Colorectal Cancer;Constipation;Data;Dementia;density;Desire for food;Development;Disease;Disease Progression;DNA Damage;Dopamine;dopaminergic neuron;Dyskinetic syndrome;Electrolyte Balance;Endocrine;enterotoxin receptor;FDA approved;Fluid Balance;Functional disorder;Gastrointestinal Hormone Receptors;gut-brain axis;Hormone secretion;Hormones;Human;Hyperphagia;Hypothalamic structure;In Vitro;in vivo;Inflammation;Injury;Intestinal Secretions;Intestines;Leptin;Ligands;Limb structure;Link;Malignant Neoplasms;Midbrain structure;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modeling;motor disorder;motor symptom;MPTP Poisoning;MPTP treatment;mRNA Expression;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neuronal Injury;Neurons;novel;novel therapeutic intervention;novel therapeutics;Obesity;Oral;Outcome;Oxidative Stress Induction;paracrine;Parkinson Disease;Pharmaceutical Preparations;Physiological;preservation;prevent;Primates;Production;protein expression;Reactive Oxygen Species;receptor;reduce symptoms;Respiration;Rodent;Role;Satiation;Signal Transduction;Structure;Substantia nigra structure;Symptoms;Syndrome;targeted treatment;Therapeutic;Toxic effect;toxicant;Toxin;transcriptome;Transgenic Mice;Translating;translational potential;translational study;uroguanylin

PROJECT_TITLE: Parkinson's disease therapies targeting GUCY2C


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: LA JOLLA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Lipoprotein(a) [Lp(a)] is a lipid-carrying particle that is causally associated with elevated cardiovascular disease risk when at elevated levels, which occurs in roughly 30% of the population. However, there are limited therapeutic options available for people with high Lp(a), especially for primary prevention. The proposed studies would help to address this unmet need by potentially providing an option for therapy with aspirin for primary prevention of cardiovascular events in a very large group of people with elevated cardiovascular risk.

PI_NAMEs: BHATIA, HARPREET SINGH (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Address;American;Antifibrinolytic Agents;Antisense Oligonucleotides;Aortic Valve Stenosis;apolipoprotein B-100;apolipoprotein Lp(a+);Aspirin;atherogenesis;Atherosclerosis;Atherosclerosis Risk in Communities;Award;Biometry;Black race;Blood Platelets;Blood specimen;Cardiology;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;career;career development;Clinic;clinical practice;clinical trial analysis;cohort;Cohort Studies;Collaborations;County;Data;Dedications;Development Plans;Diabetes Mellitus;diabetic;Dose;Elderly;Epidemiology;ethnic diversity;Event;experience;FDA approved;Fibrinolysis;Foundations;Funding;Genes;genetic analysis;genetic epidemiology;Genetic Polymorphism;Goals;Grant;Guidelines;Heart;Hemorrhage;Individual;inhibitor;Institution;Internal Medicine;Ischemia;lipid disorder;Lipids;Lipoprotein (a);Literature;Low-Density Lipoproteins;Measures;Medical;Messenger RNA;Methods;multi-ethnic;Multi-Ethnic Study of Atherosclerosis;novel;Participant;particle;patient subsets;Patients;Persons;Phase;Placebos;Plasma;Plasminogen;platelet function;Population;preservation;Prevalence;prevention clinical trial;Prevention trial;Preventive;Preventive therapy;Primary Prevention;Probability;professor;Proprotein Convertases;prospective;Prospective, cohort study;Random Allocation;Randomized;randomized trial;Recording of previous events;Research;Research Personnel;Resources;Risk;Risk Factors;risk stratification;risk/benefit ratio;Role;Sampling;secondary analysis;Secondary Prevention;Single Nucleotide Polymorphism;skills;Societies;Specific qualifier value;statistics;Subgroup;Subtilisins;Testing;Therapeutic;Thrombosis;tool;Training;United States;vascular inflammation;Woman;Women's Health;Work

PROJECT_TITLE: Aspirin for Primary Prevention of Cardiovascular Disease in Patients with Elevated Lipoprotein(a)

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


ORG_CITY: STANFORD

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE  This project aims to establish a new method for creating vaccine candidates. These vaccine candidates will work by focusing the antibody response toward particular regions of an infectious disease agent, resulting in neutralization. This new approach could be applied broadly for the creation of important, novel vaccine candidates to prevent infectious disease.

PI_NAMEs: KIM, PETER S (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Antibodies;Antibody Response;Antigens;Binding;Clinical Trials;Communicable Diseases;Ebola virus;Epitopes;Escape Mutant;Funding;high reward;high risk;HIV-1;Infection prevention;Infectious Agent;influenzavirus;Methods;Monoclonal Antibodies;neutralizing antibody;neutralizing monoclonal antibodies;novel;novel strategies;novel vaccines;prevent;Property;Research;Resolution;Surface;Testing;tool;vaccine candidate;Vaccines;Variant;Work

PROJECT_TITLE: Creating high-resolution, epitope-focused vaccines


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: We propose to study lung cancer in Uganda and Tanzania and the relationship to HIV-1 infection through three project-based and three cores. The results of these studies of the epidemiology, molecular characterization and imaging of lung cancer and the relationship to HIV infection will lead to technological transfer of instrumentation to characterize lung cancer and artificial intelligence algorithms to aid in discerning pulmonary granulomatous disease from lung cancer on radiological imaging. Findings herein may lead to the development of country-specific guidelines in the evaluation and management of lung cancer.

PI_NAMEs: GERSON, STANTON L. (contact);KIRENGA, BRUCE JAMES;MFINANGA, GODFREY SAYOKI

PROGRAM_OFFICER_NAME: DOMINGUEZ, GERALDINA

PROJECT_TERMS: actionable mutation;Address;Advocacy;Africa;African;anti-cancer research;Artificial Intelligence;artificial intelligence algorithm;biobank;Cancer Burden;cancer care;cancer diagnosis;Cancer Diagnostics;Cancer Research Network;Caring;Clinical;clinical care;clinical diagnosis;clinical epidemiology;Collaborations;Country;Detection;Development;Diagnosis;Diagnostic radiologic examination;Diagnostic Services;Disease Outcome;Epidemiology;epidemiology study;Evaluation;Future;granulomatous lung disease;Guidelines;Histologic;HIV;HIV Infections;HIV-1;Image;Immunotherapy;improved;Incidence;Individual;Infection;Institution;instrumentation;Leadership;Lung;lung cancer screening;Lung Capacity;lung imaging;Machine Learning;Malignant neoplasm of lung;Mentors;Molecular;Molecular Epidemiology;Molecular Profiling;Outcome;Pathology;Patients;Population;Prevalence;radiological imaging;Radiology Specialty;Research Personnel;Risk;Role;Sampling;scale up;screening program;Specimen;Tanzania;targeted treatment;Technology Transfer;Tissues;Training;Tuberculosis;Uganda

PROJECT_TITLE: Lung cancer in East Africa and the relationship to HIV-1 infection: epidemiology, molecular characterization and imaging


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cancer;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Lung Cancer;Rare Diseases;Telehealth;Tuberculosis

PHR: RELEVANCE – Admin Core The Administrative Core supports the goals of this U54 proposal by facilitating implementation of scientific communication, resources, and interaction between all projects, cores, and early career investigator developmental projects interrogating the underlying biology of HIV-1 infection and the causal relationship to lung cancer. The Administrative Core provides the assistance to facilitate technological equipment transfer to Uganda for lung cancer somatic mutation analysis and for DNA methylome analytics at the Joint Clinical Research Center in Kampala to which Tanzanian samples will also be sent for molecular analysis.

PI_NAMEs: GERSON, STANTON L. (contact)

PROJECT_TERMS: Address;Africa;anti-cancer research;Biology;Budgets;career;Clinical Research;Collaborations;Communication;Comprehensive Cancer Center;Development;Diagnosis;DNA;Epidemiology;Equipment;experience;Goals;granulomatous lung disease;HIV;HIV-1;Hospitals;Image;implementation facilitation;Infection;Infrastructure;Joints;Lung;Malignant neoplasm of lung;Malignant Neoplasms;Medical Research;meetings;mentoring community;Mentors;methylome;Molecular;Molecular Analysis;Mutation Analysis;Oceans;Pathology;programs;Progress Reports;Research Personnel;Research Support;Resources;Role;Sampling;Somatic Mutation;Tanzania;Technology;Telepathology;Teleradiology;Time;Training;Travel;Tuberculosis;Uganda;Universities

PROJECT_TITLE: Admin-Core


PHR: RELEVANCE - Developmental Core Lung cancer is a major national and international health problem resulting in more cancer deaths than any other cancer. The rates are increasing in the low to middle income countries where the epidemiology, outside the effect of tobacco, is not well understood. HIV-positive patients are increased risk of developing lung cancer. By providing developmental and pilot funds to highly qualified investigators early in their career we can make develop novel ideas and grow the next generation of physician scientists tackling these issues.

PI_NAMEs: DOWLATI, AFSHIN  (contact)

PROJECT_TERMS: Africa;AIDS related cancer;Applications Grants;Area;Award;Biomedical Engineering;career;career development;Cessation of life;Climate;clinical epidemiology;Clinical Oncology;Collaborations;Communication;Country;Data;Development;Development Plans;Education;Educational workshop;Ensure;Environment;Epidemiology;experience;Faculty;falls;Funding;Future;Generations;Goals;Grant;HIV Seropositivity;HIV-1;Image;imaging biomarker;Income;Infection;Infrastructure;innovation;Institution;Interdisciplinary Study;International;International Health Problems;Joints;K-Series Research Career Programs;Leadership;Link;Malignant neoplasm of lung;Malignant Neoplasms;Manuscripts;Medical Oncology;meetings;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Methods;Molecular;Molecular Medicine;Monitor;next generation;novel;Online Systems;Pathology;patient population;Patients;peer;peer coaching;Physicians;Pilot Projects;Program Development;programs;Pulmonology;Qualifying;Radiation Oncology;Radiology Specialty;Recording of previous events;recruit;Regulation;Research;Research Personnel;Research Project Grants;Resources;Risk;Running;Scholars Program;Scientist;Site;skills;Source;success;Talents;Technology;Tobacco;Training;Uganda;Universities;University Hospitals;Visit;webinar;Writing

PROJECT_TITLE: Developmental Core


NIH_SPENDING_CATS: Cancer;Clinical Research;HIV/AIDS;Infectious Diseases;Lung;Lung Cancer

PHR: RELEVANCE – Path Core The Pathology Core supports the goals of this U54 proposal, by provision of high quality diagnoses enabling enrollment of patients into each of the projects of this proposal. The Pathology Core provides abilities to digitalize images of tissues obtained from patients in Uganda and Tanzania suspected of having lung adenocarcinoma – a lesion universally recognized as being under reported in East Africa. The Core will also engage in teaching and technology transfer to sites in East Africa – since deficiencies in pathology services are regarded as one of the most pressing problems to improvement of the delivery of health care in Africa.

PI_NAMEs: WILLIS, JOSEPH EDWARD (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;Africa;African;Algorithms;American;Area;Artificial Intelligence;Awareness;Biological Specimen database;Biopsy;Biopsy Specimen;Cancer Etiology;cancer risk;case control;Categories;Classification;Clinical;Clinical Pathology;Clinical Research;Computer software;Consensus;Consultations;Core Facility;Data;Databases;demographics;design;Diagnosis;diagnosis quality;Diagnostic;diagnostic accuracy;digital;digital imaging;DNA;Educational process of instructing;Eligibility Determination;Enrollment;Epidemiology;Epidermal Growth Factor Receptor;ERBB2 gene;Ethnic Origin;Europe;Expenditure;experience;Faculty;flexibility;Funding;Gene Mutation;Goals;health care delivery;Histologic;HIV;HIV-1;Hospitals;Image;Immunohistochemistry;improved;Individual;Infection;Informatics;Infrastructure;infrastructure development;Institution;Joints;Karnofsky Performance Status;KRAS2 gene;Laboratories;Lesion;Link;Lung Adenocarcinoma;lung lesion;Malignant neoplasm of lung;Malignant Neoplasms;material transfer agreement;Medical center;Medical Research;Mission;Modernization;Molecular;mortality;Mutation Analysis;next generation sequencing;Oncology;Online Systems;Outcome;participant enrollment;Pathologic;Pathology;Patients;personalized diagnostics;Persons;Physicians;Population;programs;prospective;Pulmonary Mass;radiological imaging;Reporting;repository;Research;Resources;Risk Factors;RNA;routine care;Sampling;Scanning;Serum;Services;Site;Slide;Somatic Mutation;Specimen;Standardization;success;Surgical Pathology;System;Tanzania;Techniques;Technology;Technology Transfer;Telepathology;Tissue imaging;Tissue Sample;Tissues;translational goal;Translational Research;transmission process;Tribes;Tumor stage;Uganda;United States National Institutes of Health;Universities;University Hospitals;user-friendly;Visit;Work

PROJECT_TITLE: Pathology Core


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Clinical Research

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE Computational modeling is an enabling technology for scientific discovery and clinical care but the potential of simulations in knee biomechanics is hampered by the diversity and ambiguity of modelers’ preferences. Consensus-based workflows, which are established and evaluated for intended uses of knee models, are sorely needed to elevate knee modeling and simulation as an efficient, reliable, and scalable practice. With these, modelers will be empowered to confidently conduct large scale virtual cohort studies and routine individualized simulations that are unified across research institutions and healthcare settings.

PI_NAMEs: ERDEMIR, AHMET  (contact);HALLORAN, JASON

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: Acceleration;Adoption;Adult;Anatomy;Award;biomechanical model;Biomechanics;cartilage degradation;Clinic;Clinical;clinical care;Clinical Research;clinical translation;cohort;Cohort Studies;Collaborations;Communities;community engagement;Computer Models;Computer software;computing resources;Consensus;Consensus Development;cost effective;Data;Degenerative polyarthritis;Dependence;Development;Diagnosis;digital twin;disability;Discipline;Disease;Ecosystem;empowerment;Engineering;Etiology;Evaluation;experimental study;Foundations;Goals;Health;health care settings;Healthcare;healthcare community;Homeostasis;Implant;improved;in silico;Infrastructure;Inherited;injured;Injury;innovation;Institution;Joints;Knee;knee mechanics;Knowledge;Life Cycle Stages;Ligaments;Mechanics;Meniscus structure of joint;Methods;model building;Modeling;models and simulation;Musculoskeletal;Musculoskeletal Diseases;musculoskeletal injury;operation;Operative Surgical Procedures;Organ;Orthopedics;Outcome;Output;outreach;Pathologic;Patients;Performance;Physics;pre-clinical research;predictive modeling;preference;Prevalence;Process;Prognosis;prototype;Publishing;PubMed;Quality of life;Reconstructive Surgical Procedures;rehabilitation strategy;Rehabilitation therapy;Replacement Arthroplasty;Reproducibility;Research;Resolution;Resources;Risk;Risk Factors;Rupture;Safety;Science;simulation;Site;Source;Specificity;Standardization;Structure;Structure-Activity Relationship;Team Process;Technology;Testing;therapy design;Time;tissue reconstruction;Tissues;Uncertainty;Variant;virtual;virtual delivery;virtual experiments;Visit;Work

PROJECT_TITLE: Reproducibility in simulation-based prediction of natural knee mechanics

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Cancer;Clinical Research;HIV/AIDS;Health Services;Infectious Diseases;Lung;Lung Cancer;Prevention

PHR: RELEVANCE – Project 1 This project will provide an overall picture of lung cancer in East Africa specifically in Uganda and Tanzania and clarify the role of HIV-1 infection as a risk factor for lung cancer and progression. We will examine the clinical and demographic features of patients with lung cancer, HIV-1 infection status, laboratory and radiographical findings, and treatments administered as well as identify epidemiological risk factors.

PI_NAMEs: KASASA, SIMON  (contact)

PROJECT_TERMS: Africa;Africa South of the Sahara;Age;Air;antiretroviral therapy;Area;Biological Specimen Banks;Cancer Etiology;cancer risk;cancer survival;Caring;case control;Cessation of life;Clinical;Clinical Distribution;clinical epidemiology;Cohort Analysis;Collaborations;Cross-Sectional Studies;Data;Databases;design;Diagnosis;Disease;Epidemiologist;Epidemiology;Epidermal Growth Factor Receptor;ERBB2 gene;Etiology;Female;Genomics;Guidelines;Health Personnel;Histology;Histopathology;HIV;HIV Infections;HIV-1;HIV/AIDS;Image;Incidence;Individual;Infection;innovation;Knowledge;KRAS2 gene;Laboratories;Life;lifetime risk;Link;Logistic Regressions;low and middle-income countries;Lung nodule;male;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;men;Modeling;Modification;Molecular;mortality;multidisciplinary;Mutation;Outcome;Patients;personalized medicine;Persons;Phase;Physicians;Prevalence;Prevention program;Primary Prevention;radiological imaging;Recurrence;Reporting;Research Proposals;residence;Risk;Risk Factors;Role;ROS1 gene;screening;screening program;Series;sex;Sex Differences;Smoking;Smoking Behavior;Smoking Status;Somatic Mutation;Standardization;survival outcome;Tanzania;Thoracic Radiography;Time;tumor progression;Uganda;understudied cancer;Universities;Woman;World Health Organization

PROJECT_TITLE: Characterization of the clinical epidemiology of lung cancer and relationship to HIV-1 infection in Uganda and Tanzania


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Genetics;HIV/AIDS;Infectious Diseases;Lung;Lung Cancer;Prevention;Tobacco;Tobacco Smoke and Health

PHR: RELEVANCE – Project 2 The molecular risks of lung cancer mutation and co-incidence of HIV and accelerated aging as a factor in lung cancer incidence and progression in two East African countries will be assessed. We will characterize lung cancer somatic mutations, link them to HIV subtype/viral load/CD4 T cell counts, and explore the hypothesized role of DNA methylome aging in HIV-infected versus HIV-uninfected individuals. We will also train and transfer technological equipment to build capacity for lung cancer mutational analysis and DNA methylome aging for lung cancer and HIV in Uganda and Tanzania.

PROJECT_TERMS: Address;Adenocarcinoma;advanced disease;Africa;Africa South of the Sahara;African;Age;age acceleration;Aging;antiretroviral therapy;base;Biological Markers;Blood Cells;Cancer Patient;cancer risk;CD4 Positive T Lymphocytes;Cell Count;cohort;cooking;Country;Data;Development;Diagnosis;Disease;Disease Outcome;Disease Progression;DNA;DNA Methylation;Eastern Cooperative Oncology Group;Environmental Risk Factor;environmental tobacco smoke;Epidemiologic Factors;Epidemiology;Equipment;Future;Genomics;Genotype;Histology;HIV;HIV Infections;HIV-1;Home;Image;Immune;Immunosuppression;Incidence;Individual;Indoor Air Pollution;Infection;International;Link;Lung Capacity;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Medical center;Methylation;methylation pattern;methylome;Molecular;Molecular Profiling;Multivariate Analysis;Mutation;Mutation Analysis;Outcome;Pathologic;Patients;Performance Status;Persons;Policies;Premature aging syndrome;prospective;Relative Risks;Reporting;Risk;Risk Factors;Role;Sampling;screening;Smoker;Smoking;Somatic Mutation;South Africa;Squamous cell carcinoma;standard of care;Tanzania;Technology;Technology Transfer;therapeutically effective;Tobacco smoking behavior;Training;Transference;Tuberculosis;Tyrosine Kinase Inhibitor;Uganda;University Hospitals;Viral Load result;Virus Diseases;World Health Organization

PROJECT_TITLE: Molecular determinants of lung cancer in HIV infected and uninfected individuals in Uganda and Tanzania


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biomedical Imaging;Burden of Illness;Cancer;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Rare Diseases;Tuberculosis

PHR: RELEVANCE – Project 3 In this project, we will develop a radiomics based machine classifier called LunIRiS (Lung Image Risk Score) for predicting risk of malignancy for a nodule on a chest computed tomography (CT) or X-ray scan for use in patients in Uganda and Tanzania which has a higher prevalence of tuberculosis (TB) and hence TB- induced granulomas. Additionally, we will seek to employ these tools to identify possibly differences in the radiographic phenotype on CT and chest X-rays between HIV+ and HIV- lung cancer patients and to employ these differences to develop HIV status specific lung cancer screening models.

PI_NAMEs: MADABHUSHI, ANANT  (contact)

PROJECT_TERMS: 3-Dimensional;Affect;Africa;Age;Appearance;Architecture;Area;Artificial Intelligence;Benign;Biological Markers;Biopsy;Blood Vessels;Cancer Patient;Cells;Chest;chest computed tomography;Chronic;Clinical;cohort;Computer-Assisted Diagnosis;computerized;Decision Support Model;Detection;Development;Diagnosis;Diagnostic Specificity;Discrimination;Epidemiology;Granuloma;Granulomatous;Health;High Prevalence;HIV;HIV-1;HIV/AIDS;Human;Human Resources;Image;imaging biomarker;Immune;Immune response;improved;Incidence;Incidental Findings;Infection;innovation;Link;low dose computed tomography;Lung;lung cancer screening;lung imaging;Lung nodule;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Measurement;Medical center;Modeling;Molecular;Morphology;Nodule;novel;Online Systems;Outcome;Patients;Pattern;Persons;Phenotype;Population;radiological imaging;radiologist;Radiology Specialty;radiomics;Reaction;Reader;Reporting;respiratory;Risk;risk prediction;ROC Curve;Roentgen Rays;Scanning;screening;screening program;Sensitivity and Specificity;Services;Shapes;skills;Specificity;Specimen;Standardization;success;support tools;Surface;symptomatology;Tanzania;Technology;Teleradiology;Texture;Thoracic Radiography;Tissues;tool;Transference;Tuberculosis;Uganda;Validation;web portal;X-Ray Computed Tomography

PROJECT_TITLE: Artificial Intelligence for Lung Cancer Characterization in HIV affected populations in Uganda and Tanzania


ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Once the regulatory and signaling logic of the cell is irreversibly dysregulated by mutations, cells are no longer constrained to well-defined physiologic states but rather transition to a novel dysregulated and highly plastic landscape, where de-differentiation and trans-differentiation events become common and novel synergies with other non-transformed cell populations are forged, leading to the emergence of bona fide neomorphic organs. We propose that identifying vulnerabilities that are more universal and less likely to be defeated by the cancer cell’s remarkable adaptive nature will require a quantum leap in our ability to dissect and interrogate intra- and inter-cellular network models that are predictive of the dynamic behavior of cancer as a bona fide neomorphic organ. For this purpose, we will leverage breakthrough technology allowing silencing of thousands of genes in millions of individual cells, followed by RNA-seq profiling, thus creating the first generation of genome- and proteome-wide network models that can effectively predict the probabilistic, time-dependent response of mammalian cells to small molecule and genetic perturbations, as well as their ability to plastically reprogram across the relatively small number of molecularly distinct states detected in virtually all human malignancies.

PI_NAMEs: CALIFANO, ANDREA  (contact)

PROGRAM_OFFICER_NAME: DUECK, HANNAH RUTH

PROJECT_TERMS: Address;Affect;Behavior;Biological Assay;cancer cell;cell behavior;Cell model;Cells;CRISPR interference;curative treatments;Data;Educational process of instructing;Etiology;Event;expectation;forging;Funding;Generations;Genes;Genetic;genetic regulatory protein;Genetic Transcription;Genome;Goals;Human;Individual;Intervention;knock-down;Learning;learning network;Logic;Malignant - descriptor;Malignant Neoplasms;Mammalian Cell;Mediating;Molecular;Molecular Profiling;Mutation;Nature;network models;Normal Cell;novel;Organ;Pharmaceutical Preparations;pharmacologic;Physiological;Population;predictive modeling;Process;programs;Proteins;Proteome;quantum;Reagent;Regulation;Research;response;Series;Signal Transduction;Signaling Protein;single-cell RNA sequencing;small molecule;Statistical Models;synergism;Technology;Time;transcriptome sequencing;transdifferentiation;tumor;tumor microenvironment;virtual

PROJECT_TITLE: Predicting Cancer Cell Response to Endogenous and Exogenous Perturbations at the Single Cell Level


ADMINISTERING_IC: EY

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences;Nutrition

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Dysregulation of lipid metabolism is strongly associated with age-dependent retinal diseases based on genetic and epidemiological studies. Using mouse models showing impairment of lipid metabolism and cellular homeostasis in the retina, we propose to study how dysregulated lipid metabolism impacts retinal health and lead to age-dependent retinal diseases. This study may provide insights into how age-dependent retinal pathologies are caused and offer therapeutic strategies for prevention of retinal conditions associated with aging and age-dependent retinal disorders.

PI_NAMEs: IKEDA, AKIHIRO  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Ablation;Abnormal Epithelial Cell;Acetyl-CoA Carboxylase;Affect;age acceleration;age related;age related changes;Age related macular degeneration;age-related disease;Aging;aging related;Binding;Cells;Choroid;Data;Development;differential expression;disease phenotype;Docosahexaenoic acid supplementation;epidemiology study;fatty acid metabolism;Fatty Acids;functional loss;Funding;Gene Expression;Genes;Genetic study;Health;Hepatic;Homeostasis;Impairment;Inflammation;insight;Integral Membrane Protein;Lead;lipid metabolism;lipidomics;Liver;Mitochondria;Molecular Genetics;Morphology;mouse model;Mouse Strains;Mus;mutant;Mutant Strains Mice;Mutation;novel;Organelles;overexpression;Pathology;Pathway interactions;Patients;peroxisome;Photoreceptors;Play;Prevention strategy;Process;Production;Regulation;Regulatory Element;Retina;Retinal Degeneration;Retinal Diseases;Role;Site;Sterols;Structure of retinal pigment epithelium;Supplementation;Testing;Therapeutic;tool;transcription factor;Up-Regulation

PROJECT_TITLE: Molecular Genetics of Age-Dependent Retinal Degeneration

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Bioengineering;Cardiovascular

ORG_CITY: Aurora

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Narrative This program aims to train the next generation of scientists to perform research and training at the interface between cardiovascular medicine and bioengineering. The program aims to provide trainees with sound engineering breadth and depth, as well as a robust understanding of clinical and biomedical research and vocabulary in the cardiovascular sciences.

PI_NAMEs: SHANDAS, ROBIN  (contact)

PROJECT_TITLE: Cardiovascular Biomechanics and Imaging

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Immunization;Prevention;Regenerative Medicine

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Heart attacks are the major cause of heart failure in the Western world. In this proposal we identify and develop a clinical monoclonal antibody candidate targeting a specific protein in the heart that worsens heart repair after heart injury.

PI_NAMEs: DEB, ARJUN  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Acute;Acute myocardial infarction;Adenine;Adenosine;Adrenergic beta-Antagonists;Affect;Aldosterone;Aldosterone Antagonists;Anabolism;Angiotensin Receptor;Angiotensin-Converting Enzyme Inhibitors;Angiotensins;Animals;antagonist;antibody engineering;Apoptosis;Apoptotic;Attenuated;base;Biodistribution;Biological;Biological Response Modifier Therapy;Biotechnology;Cardiac;Cardiac Myocytes;cardiac repair;cardiovascular pharmacology;Cardiovascular system;Catalytic Domain;Cell Cycle;Cell Death;Cell Death Induction;Cell Proliferation;Cells;Chronic;Cicatrix;Clinical;clinical candidate;clinical investigation;Collaborations;Computational Biology;CRISPR/Cas technology;Data;Development;Diagnosis;Dilatation - action;DNA Damage;Dose;Drug Kinetics;ecto-nucleotidase;efficacy study;Endothelial Cells;Engineering;Enzymes;extracellular;Fibroblasts;Fibrosis;Functional disorder;Future;gain of function;Generations;Genetic;Genetic Transcription;Genetically Engineered Mouse;Goals;Half-Life;healing;Heart;Heart failure;heart function;Heart Injuries;hemodynamics;Human;humanized monoclonal antibodies;humanized mouse;Impairment;Induced Cardiomyocytes;Infarction;Inflammation;Inflammatory;insight;Integral Membrane Protein;Investments;ischemic injury;Journals;loss of function;Macrophage;Medical;Metabolic;Metabolism;metabolomics;Modeling;Molecular;Monoclonal Antibodies;mouse model;multidisciplinary;Mus;Muscle Cells;Myocardial Infarction;Myocardial Ischemia;Myocardium;Natural regeneration;Necrosis;novel;Nuclear;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;phosphoric diester hydrolase;Phosphorylases;Physiological;Physiology;plasma cell membrane glycoprotein PC-1;porcine model;preclinical study;preservation;prevent;Prevention;Proteins;Publishing;Purine Nucleosides;Purines;Pyrimidine;pyrophosphatase;repaired;response;response to injury;Role;safety study;Signal Transduction;Survival Rate;Technology;Testing;Therapeutic;Therapeutic Uses;Time;Tissue-Specific Gene Expression;Tissues;Toxic effect;Transgenes;treatment strategy;United States;Ventricular;Ventricular Remodeling;Western World;wound healing

PROJECT_TITLE: Targeting a ectonucleotidase in the heart with a monoclonal antibody to prevent post-infarct heart failure

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RCCS-Q(02)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Genetics;Human Genome;Immunization;Immunotherapy;Networking and Information Technology R&D (NITRD);Precision Medicine;Vaccine Related

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Narrative The creation of the Cancer Immune Monitoring and Analysis Center (CIMAC) program as part of the Cancer Moonshot Research Initiative established an unprecedented multi-institute network that delivers a more standardized analysis of biospecimens from immunotherapy clinical trials. The goal of this application is to not let this valuable resource go to waste but rather to continue the work by applying proven assays to a greater number of trials and by expanding the scope and sophistication of analysis with more comprehensive methods coupled with enhanced bioinformatic tools for facile data processing and improved biomarker identification. Our network will continue its mission to support, harmonize, compare, and disseminate existing and new approaches aimed at learning the mechanisms underlying responses to immune-based therapies for the treatment of cancer.

PI_NAMEs: HODI, FRANK S;WU, CATHERINE JU-YING (contact)

PROGRAM_OFFICER_NAME: THURIN, MAGDALENA

PROJECT_TERMS: Acceleration;Address;Adoptive Cell Transfers;Allogenic;Antigens;Automobile Driving;bioinformatics tool;Biological;Biological Assay;Biological Markers;Biology;biomarker identification;Blood;Blood specimen;cancer cell;cancer immunotherapy;cancer therapy;Cancer Therapy Evaluation Program;cancer type;Cells;chimeric antigen receptor T cells;Clinical;Clinical Trials;Clone Cells;Collaborations;Communication;Complex;computerized data processing;computerized tools;Coupled;Dana-Farber Cancer Institute;Data;Data Analyses;data integration;Data Set;data standards;design;Detection;Development;Epitopes;Evaluation;flexibility;Fostering;Genomics;Germ Lines;Goals;high dimensionality;imaging modality;Immune;immune checkpoint blockade;Immune response;Immunologic Monitoring;Immunooncology;Immunotherapeutic agent;Immunotherapy;immunotherapy clinical trials;immunotherapy trials;improved;Individual;innovation;Institution;inter-institutional;investigator-initiated trial;Knowledge;Laboratories;Learning;Life;Link;Machine Learning;Malignant Neoplasms;Methods;Mission;Modality;molecular marker;Monitor;Motivation;Movement;Multiomic Data;multiple omics;novel;novel strategies;novel therapeutics;Oncolytic viruses;patient subsets;Patients;Performance;Peripheral;personalized cancer therapy;Phase;Phenotype;Population;Principal Investigator;Process;process improvement;programs;Protocols documentation;Radiation therapy;Recording of previous events;Research;Resistance;Resources;response;response biomarker;Role;Series;single cell analysis;Site;Specimen;Stains;standard of care;Standardization;Stem cell transplant;success;T-Cell Immunologic Specificity;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Testing;Therapeutic;therapy resistant;Tissue Sample;Tissues;tool;tool development;Toxic effect;transcriptomics;treatment response;tumor;tumor microenvironment;tumor-immune system interactions;United States National Institutes of Health;Vaccine Therapy;Validation;Variant;wasting;Work;Writing


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project narrative The proposed research is relevant to public health because it is aimed at addressing low utilization of mental health services that leads to delayed diagnosis and treatment, and increased morbidity and mortality related to mental illness among Black adults. The proposed research is relevant to the mission of the NIMH to enhance the efficacy and precision of interventions, as it is proposed to design and test the feasibility of an anti-stigma intervention that better defines the optimal intervention conditions and mechanistic targets (stigma and medical mistrust) to promote uptake of mental health services. Thus, the findings are expected to enhance mental health treatment outcomes among millions of Black adults with mental illness in the United States.

PI_NAMEs: BAMGBOSE PEDERSON, ADERONKE  (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adult;Affect;Anxiety;Anxiety Disorders;Applications Grants;Attitude;Award;Behavior;Belief;Black Populations;Black race;care providers;Caring;Characteristics;Chronic;Chronic Disease;clinical trial analysis;Clinical Trials;community building;community engaged research;community engagement;Conduct Clinical Trials;Country;Data;design;Diagnosis;digital mental health;disability;Disease;Ethnic Origin;experience;feasibility testing;Foundations;Future;Goals;Health;health disparity;health inequalities;Health Knowledge Attitudes Practice;Health Promotion;health service use;Health Services Accessibility;Healthcare;Healthcare Systems;help-seeking behavior;improved;Individual;innovation;Institution;internalized stigma;Intervention;intervention effect;intervention refinement;Intervention Trial;Literature;Major Depressive Disorder;Measures;Mediating;Mediation;Medical;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Mentors;Mentorship;Meta-Analysis;Methodology;mhealth interventions;Mission;mobile application;Morbidity - disease rate;mortality;National Institute of Mental Health;novel;Outcome;Participant;Patients;personal narratives;personalized intervention;Persons;post intervention;preference;Premature Mortality;primary outcome;Process;Public Health;Qualitative Research;Race;racism;Randomized;randomized trial;Randomized, Controlled Trials;Recording of previous events;Recovery;recruit;Religiosity;Research;Research Methodology;Research Personnel;Role;satisfaction;secondary outcome;Self Administration;service engagement;service utilization;skills;social stigma;Stigmatization;Symptoms;Testing;therapy design;therapy development;Training;treatment arm;Treatment outcome;trial design;United States;uptake;usability;user centered design;Waiting Lists

PROJECT_TITLE: Design and Feasibility of a Mobile Mental Health Stigma Reducing Intervention towards Optimization of Care for Black Adults with Depression and Anxiety

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_DEPT: PHARMACOLOGY

PHR: Soluble adenylyl cyclase (sAC) is essential for sperm function, and both men and male mice with the sAC gene deleted are sterile with no other immediate phenotypes. Mice given a single dose of an acute acting sAC inhibitor are temporarily infertile with no other observable side effects. Our goal is to develop sAC inhibitors into safe, `on-demand' male birth control pills whose effects would be temporary and taken only when, and as often as needed.

PI_NAMEs: BUCK, JOCHEN ;LEVIN, LONNY R (contact)

PROGRAM_OFFICER_NAME: LINDSEY, CHRISTOPHER CHARLES

PROJECT_TERMS: Acrosome Reaction;Acute;Adenylate Cyclase;Adverse effects;Affinity;Animal Model;Bicarbonates;Binding;Biochemistry;Biological Availability;Biology;Biotechnology;Cervix Uteri;Characteristics;Chemicals;Chronic;Clinical;clinical development;Contraceptive Agents;contraceptive efficacy;Contraceptive methods;Data;Deposition;design;Dose;Drug Design;drug development;drug discovery;Drug Kinetics;early phase clinical trial;Ejaculation;Epididymis;Equilibrium;Event;expectation;experimental study;Fertility;Fertilization in Vitro;Gene Deletion;Glaucoma;Goals;Human;improved;in vivo;in vivo evaluation;Infertility;inhibitor;innovation;Investigational Drugs;Investigational New Drug Application;Investments;Kidney Calculi;Kinetics;Knock-out;knockout gene;Knockout Mice;lead candidate;male;Male Contraceptive Agents;male fertility;Mammalian Oviducts;Measures;Medicine;men;Methodology;Methods;Molecular;Motility;Mouse Strains;multidisciplinary;Mus;Mutation;novel;Oocytes;Oral;Oral Contraceptives;Oryctolagus cuniculus;Ovulation;Partner in relationship;Pharmaceutical Preparations;pharmacodynamic biomarker;pharmacologic;Pharmacologic Substance;Pharmacology;Phase;Phenotype;Physiologic Intraocular Pressure;Physiology;pre-clinical;preclinical study;prevent;Process;Property;Research;research and development;Research Contracts;Research Project Grants;Resources;Safety;scaffold;Series;sex;side effect;small molecule inhibitor;sperm cell;sperm function;Sperm Motility;Spermatocytes;Sterility;structural biology;Structure;success;Swimming;Testing;Therapeutic;Time;Tissues;Topical application;Travel;USAID;Uterus;Vagina;Vaginal Ring;Validation;Woman;Work;zygote

PROJECT_TITLE: On-demand nonhormonal male contraception via ADCY10 inhibition


NIH_SPENDING_CATS: Contraception/Reproduction;Prevention

PI_NAMEs: LEVIN, LONNY R (contact)

PROJECT_TERMS: Adenylate Cyclase;Advisory Committees;Affect;Animal Model;Biochemistry;Biological Availability;Biotechnology;Characteristics;Chemicals;Communication;Computer Models;Contraceptive Agents;contraceptive efficacy;Contraceptive methods;Crystallography;Data;design;drug development;drug discovery;Drug Kinetics;drug quality;early phase clinical trial;Elements;Ensure;Enzymatic Biochemistry;Evaluation;Fertilization;Fostering;Funding;Goals;Human;Human Resources;improved;in vivo;Infertility;inhibitor;Institution;Institutional Review Boards;Investigational New Drug Application;Lead;Link;Maintenance;male;Male Contraceptive Agents;Marketing;mating behavior;Medicine;member;men;Mus;National Institute of Child Health and Human Development;Oral;Oral Contraceptives;outreach;Partner in relationship;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacodynamic biomarker;pharmacologic;Pharmacologic Substance;Pharmacology;Physiology;pill;Positioning Attribute;preclinical development;preference;prevent;Principal Investigator;programs;Property;Quality Control;recruit;Reproductive Biology;Research;Research Activity;Research Personnel;Resources;scaffold;Series;sperm cell;Sperm Motility;structural biology;Structure;Therapeutic;Time;tool;Work

PROJECT_TITLE: Administrative Core


PROJECT_TERMS: Acute;Adenylate Cyclase;analog;Anti-viral Agents;Binding;Biochemical;Biochemistry;Biological Assay;biophysical analysis;Biophysics;Cell Line;Cellular Assay;Characteristics;chemical synthesis;Chemicals;Complex;Computer Models;Contraceptive Agents;contraceptive efficacy;Contraceptive methods;Crystallography;Cyclic AMP;Darkness;Deposition;design;Development;Devices;Dose;Drug Design;drug development;Drug Kinetics;efficacy evaluation;Ejaculation;Elements;Engineering;Environment;Enzymes;experimental study;female reproductive tract;Goals;GTP-Binding Proteins;Guanylate Cyclase;Human;improved;In Vitro;in vivo;Individual;Infertility;inhibitor;Kinetics;Laboratories;Lead;lead optimization;Light;male;Male Contraceptive Agents;male fertility;man;Measures;Medicine;Membrane;Modeling;Molecular Conformation;Mus;novel;Oral Contraceptives;Oranges;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phase;Physiology;pre-clinical;Printing;Property;Proteins;Protocols documentation;Publications;rational design;Reproducibility;Research;residence;Resolution;scaffold;scale up;Seminal fluid;Series;sex;Specificity;sperm cell;structural biology;Structure;Surface Plasmon Resonance;Testing;Time;tool;Topical application;Toxic effect;Update;uptake;USAID;Vaginal Ring;Woman;Work;X-Ray Crystallography

PROJECT_TITLE: Target Engagement


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Immunization;Infectious Diseases;Lyme Disease;Prevention;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: SAN ANTONIO

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

PHR: PUBLIC HEALTH RELEVANCE: Borrelia burgdorferi (Bb), the causative agent of Lyme disease, is the most prevalent arthropod-borne infectious agent in the US and causes significant morbidity and extensive health care costs in endemic areas where the disease is prevalent. The proposed studies are directed at evaluating genetically defined mutants that hyper-express a number of lipoproteins as reservoir bait vaccines to limit or eliminate the survival of Bb in experimental and reservoir mouse models. Several adjuvants will be evaluated for stimulating protective immune response against Lyme disease pathogen as a single dose, oral, reservoir-targeted vaccine to interrupt natural history of infection leading to a reduction in the incidence of Lyme disease.

PI_NAMEs: SESHU, JANAKIRAM  (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: adaptive immune response;Adjuvant;Aftercare;Anti-Bacterial Agents;Antibiotics;Antibodies;Antigens;Area;arthropod-borne;Bite;Black-legged Tick;Borrelia;Borrelia burgdorferi;C3H/HeN Mouse;Carbon;Centers for Disease Control and Prevention (U.S.);Cues;Disease;dosage;Dose;efficacy evaluation;Engineering;enzootic;Escherichia coli;Formulation;Gene Expression Regulation;Gene Modified;Genetic Engineering;Genetically Modified Organisms;Goals;Health Care Costs;Human;Immune response;Immunity;Immunization;Immunize;Incidence;Infection;Infectious Agent;Interruption;Larva;Life Cycle Stages;Lipoproteins;Lyme Disease;M cell;Molecular Conformation;Morbidity - disease rate;mouse model;Mus;mutant;Natural History;Nature;novel;novel strategies;Nymph;Oral;Oral Administration;oral vaccine;Order Spirochaetales;Organism;OspA protein;OspC protein;parenteral administration;pathogen;pathogenic bacteria;Patients;Peptides;Peromyscus;prevent;Prevention;Property;public health relevance;Recombinant Proteins;Recommendation;reconstitution;Reporting;Research;response;RNA-Binding Proteins;Route;Site;Surface;Symptoms;System;Testing;Tick-Borne Diseases;tick-borne pathogen;Ticks;tool;transmission blocking;transmission process;treatment choice;Vaccinated;Vaccination;vaccine access;vaccine development;vaccine platform;Vaccines;vector tick;White-Footed Mouse

PROJECT_TITLE: Efficacy of novel reservoir-host targeted bait formulations against a tick-borne pathogen


NIH_SPENDING_CATS: Anxiety Disorders;Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Both adversity and psychopathology experienced in early childhood are profound, yet nonspecific, risk factors for adolescent mental health problems. Identifying neural pathways through which early adversity and psychopathology lead to this risk may improve our prediction models, directly addressing prevention and intervention science. The current study, building on a large and well-characterized existing cohort, is efficiently designed to test specific neural pathways linking adversity and psychopathology in preschool to adolescent psychopathology individually and interactively.

PI_NAMEs: CARPENTER, KIMBERLY L H;COPELAND, WILLIAM ;SHERIDAN, MARGARET ANN (contact)

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: 10 year old;Address;Adolescence;Adolescent;adolescent mental health;adverse childhood events;Age;aged;Amygdaloid structure;Anxiety;Anxiety Disorders;anxiety symptoms;associated symptom;Attention deficit hyperactivity disorder;Behavior;Behavioral;Brain;case control;Child;Childhood;Cognitive;cognitive control;cognitive function;cohort;Communities;comorbidity;cost effective;Data;deprivation;design;Development;Diagnosis;Diagnostic;Dimensions;Disease;disorder risk;Disruptive Behavior Disorder;early childhood;early life adversity;emotion dysregulation;emotion regulation;Enrollment;experience;Functional disorder;Functional Imaging;Future;gray matter;Hyperactivity;imaging study;Impairment;improved;Impulsivity;Individual;innovation;Interpersonal Violence;Intervention;Knowledge;Lead;Limbic System;Link;Mediator;Methods;Modeling;National Institute of Mental Health;Nature;negative affect;neural;neural circuit;Neural Pathways;Neurobiology;neurodevelopment;Neurophysiology - biologic function;novel;Nursery Schools;Oppositional Defiant Disorder;Outcome;Parents;Participant;Pathway interactions;poor communities;predictive modeling;Prefrontal Cortex;Preschool Child;Prevention;preventive intervention;primary care clinic;Process;Psychopathology;Questionnaires;recruit;Reporting;Research;Resources;Rest;Risk;Risk Factors;Sampling;Science;serial imaging;Severities;social;Strategic Planning;structural imaging;Structure;Testing;Vulnerable Populations

PROJECT_TITLE: Neural pathways linking early adversity and preschool psychopathology to adolescent mental health

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PROJECT_TERMS: Acute;Adenylate Cyclase;Affinity;analog;Animal Testing;Bicarbonates;Binding;Biological Assay;Biological Availability;Biotechnology;Cells;Characteristics;Chemicals;clinical development;Contraceptive Agents;Contraceptive methods;cross reactivity;Cyclic AMP;cytotoxicity;Data;design;Development;Dose;Drug Design;Drug Kinetics;Ejaculation;Enzymes;Epididymis;Exhibits;experimental study;female reproductive tract;Fertilization;Fertilization in Vitro;Funding;Genetic;Glaucoma;Goals;Hour;Human;improved;In Vitro;in vivo;Infertility;inhibitor;Injections;Investigational New Drug Application;Investments;Kidney Calculi;Kinetics;Knock-out;Knockout Mice;lead optimization;loss of function;male;Male Contraceptive Agents;male fertility;Male Infertility;Mammalian Oviducts;Mediating;Medicine;member;men;Metaphase;middle age;Molecular;Motility;Mouse Strains;Mus;Mutation;novel;Oocytes;Oral;Oral Contraceptives;Oryctolagus cuniculus;Ovulation;Partner in relationship;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phenotype;Physiologic Intraocular Pressure;pill;pre-clinical;preclinical development;Preclinical Testing;prevent;Process;Property;Proteins;Research;research and development;research clinical testing;Research Project Grants;residence;Resources;response;reversible contraceptive;scaffold;Second Messenger Systems;Series;sex;side effect;Source;sperm cell;sperm function;Sperm Motility;Spermatocytes;Sterility;Structure;Swimming;Testing;Tissues;tool;Topical application;Travel;USAID;Vaginal Ring;validation studies

PROJECT_TITLE: Optimization of in vivo validated ADCY10 inhibitors


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Aging is characterized by a gradual decline in function across multiple organ systems and this decline sensitizes these systems to disease. As a consequence, chronological age is a well-known risk factor for many human diseases including cancer, osteoporosis, cardiovascular disease, dementia, type 2 diabetes, glaucoma and others. The research proposed will contribute new therapies to promote brain health across age, and help postpone the cognitive and mental health deterioration that occurs with age.

PI_NAMEs: DAVIS, RONALD L (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Abbreviations;Adult;Age;age effect;age-related disease;Aging;aging brain;Algorithms;analog;Anxiety;Behavior;Behavioral Assay;Biological Assay;Body System;Brain;brain health;Cardiovascular Diseases;Cell Physiology;Chronic;Chronology;Clinical;Clinical Treatment;Cognition;Cognitive;Collection;Data;Dementia;Deterioration;Disease;drug discovery;drug metabolism;Drug Screening;drug-like compound;Elderly;functional decline;Functional disorder;Future;Generations;Glaucoma;Goals;hallmarks of aging;Health;Health Status;Human;human disease;Impairment;improved;In Vitro;in vitro Assay;in vivo;in vivo evaluation;Laboratory Animals;Lead;lead optimization;Learning;Length;Libraries;Literature;Malignant Neoplasms;Measures;Memory;Mental Depression;Mental Health;Metabolic;middle age;Mitochondria;mitochondrial therapeutics;Modeling;Neurons;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;old mice;Organelles;Organism;Osteoporosis;Parents;Penetration;Pharmaceutical Preparations;Phase;Pilot Projects;Population;Prevention;Property;Recording of previous events;Research;research and development;response;Risk Factors;Sampling;screening;Shapes;small molecule;small molecule therapeutics;success;System;Testing;Therapeutic;Time;Triage

PROJECT_TITLE: Mitochondrial therapeutics for healthy brain aging

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


PI_NAMEs: BUCK, JOCHEN  (contact)

PROJECT_TERMS: Acute;Adenylate Cyclase;Animal Model;Animals;Bicarbonates;Biological Markers;birth control;Cervical;Cervix Mucus;Clinical;Clinical Research;Clinical Trials;Clinical Trials Design;Collection;Contraceptive Agents;contraceptive efficacy;Contraceptive methods;Couples;Cyclic AMP;Data;Deposition;Development;Dose;drug candidate;Drug Design;drug development;Drug Kinetics;Drug Packaging;early phase clinical trial;efficacy evaluation;Ejaculation;Environment;Epididymis;experimental study;Family Planning;Female;female reproductive tract;Fertilization;Fertilization in Vitro;first-in-human;flexibility;Genetic;Goals;Hour;Human;In Vitro;in vivo;in vivo evaluation;Infertility;inhibitor;Injections;innovation;Investigational Drugs;Investigational New Drug Application;Knock-out;knockout gene;Lead;lead candidate;loss of function;male;Male Contraceptive Agents;male fertility;Mammalian Oviducts;Mediating;Medicine;men;Menstrual cycle;Methods;Motility;Mus;new chemical entity;novel;Oocytes;Oral;Oral Contraceptives;Oryctolagus cuniculus;Ovulation;Partner in relationship;Pharmaceutical Preparations;pharmacodynamic biomarker;pharmacologic;Phase;Phase I Clinical Trials;Phenotype;pre-clinical;pre-clinical research;prevent;Process;Property;Reflex action;Research;Research Project Grants;residence;response;Rodent;Safety;safety testing;Second Messenger Systems;Seminal fluid;sex;side effect;Source;sperm cell;Sperm Motility;Spermatocytes;Sterility;Structure;Study models;Swimming;Testing;Time;Tissues;Toxicology;Translational Research;Travel;Uterus;Vagina;Woman

PROJECT_TITLE: Assessing inhibitor efficacy in vivo and developing a biomarker for use during early phase clinical trials


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Genetics;Immunotherapy;Pancreatic Cancer;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE The goal of this grant is to dissect the contribution of fibroblast derived WNT ligands to activation of WNT signaling in T cells and to the shaping of the tumor microenvironment. We will then study the role of the WNT effector TCF1 in pancreatic cancer infiltrating T cells. Finally, we will harness our findings to design and test a novel combination targeting approach for this disease.

PI_NAMEs: PASCA DI MAGLIANO, MARINA  (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Ablation;Acylation;Adult;advanced disease;Affect;Animals;Binding;cancer infiltrating T cells;carcinogenesis;CD4 Positive T Lymphocytes;Cell Communication;Cell Compartmentation;cell type;Cells;Characteristics;chemotherapy;Coculture Techniques;Combined Modality Therapy;Data;design;Disease;disease model;Disease Progression;Embryo;Enzymes;Epithelial Cells;Epithelium;Family;Fibroblasts;Gene Expression Profile;Genes;Genetically Engineered Mouse;Goals;Grant;Growth;Human;human RNA sequencing;Immune;immune cell infiltrate;immune checkpoint blockade;Immunologic Sensitization;immunoregulation;Immunosuppression;Immunotherapy;inhibitor;KRAS oncogenesis;KRAS2 gene;Lesion;Ligands;Maintenance;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;MAP Kinase Gene;Maps;Mediating;Mediator;MEKs;Membrane;Mus;Mutation;Neoplasm Transplantation;neoplastic cell;Non-Malignant;novel;novel therapeutic intervention;Oncogenic;Organoids;Pancreas;Pancreas Transplantation;pancreatic cancer cells;pancreatic cancer model;pancreatic cancer patients;Pancreatic Intraepithelial Neoplasia;pancreatic tumorigenesis;Pathway interactions;pharmacologic;Phenotype;Porcupines;prevent;Proteins;Reaction;receptor;recombinase;Regulation;Resistance;Role;Sampling;Shapes;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Source;System;T cell differentiation;T-Cell Activation;T-Lymphocyte;TCF Transcription Factor;Testing;transcription factor;tumor;tumor ablation;Tumor Immunity;tumor microenvironment;Tumor Suppressor Proteins;tumor-immune system interactions;Up-Regulation;WNT Signaling Pathway

PROJECT_TITLE: Targeting the fibroblast-immune cell crosstalk to relieve immune suppression in the pancreatic cancer microenvironment

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Eye Disease and Disorders of Vision;Prevention

PROJECT_TERMS: Acute;Adenylate Cyclase;Animal Model;Bicarbonates;Binding;Biochemical;Biochemistry;Biological Assay;Cells;Chemicals;clinical development;Contraceptive Agents;Contraceptive methods;cross reactivity;Cyclic AMP;cytotoxicity;Data;Development;Dose;Drug Design;drug discovery;Ejaculation;Epididymis;Exhibits;experimental study;Failure;Female;female reproductive tract;Fertilization;Fertilization in Vitro;Funding;Genetic;Glaucoma;Goals;high throughput screening;Hour;Human;improved;in vivo;Infertility;inhibitor;Injections;Institution;Kidney Calculi;Kinetics;Knock-out;Knockout Mice;Lead;lead optimization;loss of function;male;Male Contraceptive Agents;male fertility;Male Infertility;Mammalian Oviducts;Measures;Mediating;Medicine;men;Metaphase;Methods;middle age;Molecular;molecular modeling;Motility;Mouse Strains;Mus;Mutation;novel;novel therapeutics;Oocytes;Oral Contraceptives;Ovulation;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phenotype;Physiologic Intraocular Pressure;pre-clinical;prevent;Process;Property;Proteins;Reproductive Physiology;Research;research and development;Research Project Grants;residence;response;reversible contraceptive;scaffold;Second Messenger Systems;Series;sex;side effect;small molecule;Source;sperm cell;sperm function;Sperm Motility;Spermatocytes;Sterility;structural biology;Structure;success;Swimming;Testing;Therapeutic;Time;Tissues;Travel

PROJECT_TITLE: Development of new ADCY10 inhibitors


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Networking and Information Technology R&D (NITRD);Patient Safety;Physical Activity;Physical Rehabilitation;Rehabilitation;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Twenty percent of patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease (COPD) are readmitted within 30 days of discharge. Pulmonary rehabilitation is associated with a reduction in hospitalization in patients with COPD, but significant barriers in availability and access limit its use. We propose a multicenter randomized controlled trial that will test whether a video telehealth pulmonary rehabilitation intervention that overcomes these barriers will reduce hospital readmissions, improve quality of life, and be cost-effective.

PI_NAMEs: BHATT, SURYA P. (contact)

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: Activities of Daily Living;Acute;Admission activity;Aerobic Exercise;Affect;Anti-Inflammatory Agents;biological adaptation to stress;Breathing Exercises;Bronchodilator Agents;care delivery;Case Report Form;Certification;Chronic Obstructive Pulmonary Disease;Communities;comparative cost effectiveness;comparative efficacy;copayment;cost;cost effective;Cost Savings;cost-effectiveness evaluation;cost-effectiveness ratio;Data;Data Management Resources;deconditioning;Development;Disease;Dropout;Dyspnea;Economic Factors;Education;Effectiveness of Interventions;Eligibility Determination;Enrollment;Equipment;Event;Exercise;exercise capacity;Exercise Tolerance;Feedback;Fees;Focus Groups;follow-up;Functional disorder;functional status;Geographic Locations;Health;Health Care Costs;Healthcare;Home;hospital readmission;Hospitalization;Hospitals;improved;incremental cost-effectiveness;indexing;Insurance Coverage;Intervention;Length of Stay;Lung;Manuals;Medical;Monitor;Moods;Morbidity - disease rate;Multi-Institutional Clinical Trial;Multicenter Trials;muscle strength;Online Systems;Outcome;Oxidative Stress;Patients;Pharmaceutical Preparations;Phase;prevent;Procedures;programs;prospective;Protocols documentation;psychologic;pulmonary rehabilitation;Quality of life;Quality-Adjusted Life Years;Randomized;Randomized, Controlled Trials;readmission rates;readmission risk;Recovery of Function;Rehabilitation Centers;Reporting;resilience;resistance exercise;Resource-limited setting;Resources;respiratory;respiratory morbidity;rural area;rural patients;Safety;secondary outcome;Self Efficacy;Service delivery model;Skeletal Muscle;social;socioeconomics;standard of care;Stress;symptom treatment;Symptoms;telehealth;Testing;Time;Transportation;trial comparing;underserved area;United States;uptake;urban area;urban underserved;Visit;Walking

PROJECT_TITLE: 1/2 Video Telehealth Pulmonary Rehabilitation to Reduce Hospital Readmission in Chronic Obstructive Pulmonary Disease (Tele-COPD)

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(MA)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Hypertension;Patient Safety;Prevention

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative This project proposes a systematic, large-scale observational study comparing the effectiveness and safety of the second antihypertensive drugs added to monotherapy in people with hypertension in real-world settings. The proposed project is relevant to public health because it provides critical information to inform decisions about randomized trials for hypertension treatment escalation and the highest quality non-randomized evidence to support guideline recommendations. The proposed research is relevant to National Heart, Lung, and Blood Institute’s Strategic Goals and Objectives, specifically objective 6, to optimize clinical and implementation research to improve health and reduce disease.

PI_NAMEs: LU, YUAN  (contact)

PROGRAM_OFFICER_NAME: POOL, LINDSAY REGINA

PROJECT_TERMS: active comparator;Acute Kidney Failure;Address;Adult;Adverse event;Age;American;American Heart Association;Angioneurotic Edema;Anti-Hypertensive Agents;Benefits and Risks;blood pressure control;Calibration;Cardiology;Cardiovascular system;Characteristics;Clinical;Clinical Informatics;clinical practice;Clinical Practice Guideline;Clinical Research;college;comorbidity;comparative;comparative effectiveness;comparative safety;compare effectiveness;Consumption;Data;Data Set;Databases;design;Development;Disease;Drug Combinations;Effectiveness;effectiveness evaluation;Electronic Health Record;Ethnic Origin;evidence based guidelines;experimental study;Future;Gastrointestinal Hemorrhage;Goals;Guidelines;head-to-head comparison;Health;Healthcare;Heart failure;Heterogeneity;Hospitalization;hyperkalemia;Hypertension;hypertension control;hypertension treatment;implementation research;implementation science;improved;innovation;Level of Evidence;Methods;Modeling;Morbidity - disease rate;mortality;multidisciplinary;Myocardial Infarction;National Heart, Lung, and Blood Institute;Observation in research;Observational Study;Outcome;patient subsets;Patients;Pattern;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;Pharmacotherapy;prevent;Public Health;Publication Bias;Race;randomized trial;Randomized, Controlled Trials;Recommendation;Reproducibility;Research;Research Design;Research Methodology;Risk;Safety;sex;Specific qualifier value;Stroke;Testing;Time;Translating;trial comparing;United States Department of Veterans Affairs;Variant;Work

PROJECT_TITLE: Real-world Evidence to Inform Decisions for Hypertension Treatment Escalation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-P(90)S]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Substance Misuse

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Project Narrative The rapid formation of new memories and the recall of old memories to inform decisions is essential for human cognition, but the underlying neural mechanisms remain poorly understood. The objective of this application is to assemble a multi-disciplinary and multi-site team with the expertise and patient volume to test key predictions on the neural substrate of human memory that can only be evaluated by observing and studying neurons in-vivo in humans enabled by rare neurosurgical opportunities. This innovative approach permits us to investigate circuit-level mechanisms of human memory that cannot be studied non-invasively in humans nor in animal models due to their unclear relevance to human memory and its diseases.

PI_NAMEs: MAMELAK, ADAM NATHANIEL;RUTISHAUSER, UELI  (contact)

PROGRAM_OFFICER_NAME: GEBREHIWET, HERMON RUSSOM

PROJECT_TERMS: Animal Model;Area;Attention;awake;Behavior;Behavioral;Behavioral Model;Binding;Brain;BRAIN initiative;Cells;Child;Clip;Cognition;Cognitive;Communities;Computer Analysis;Computer Models;Data;Data Set;data standards;Decision Making;design;Detection;Development;Disease;Electric Stimulation;Electrodes;Epilepsy;Episodic memory;Ethics;Etiology;Event;experience;experimental study;flexibility;Fostering;frontal lobe;Goals;Human;Implant;Implanted Electrodes;in vivo;Infrastructure;innovation;insight;Institution;Intractable Epilepsy;Investigation;Knowledge;Link;long term memory;Maintenance;Medial;medial temporal lobe;meetings;Memory;Memory Disorders;memory recognition;memory retrieval;Methods;Modeling;movie;multidisciplinary;Nervous System;neural;neural patterning;neuromechanism;Neuronal Differentiation;Neurons;neurophysiology;Neurosciences;neurosurgery;neurotransmission;novel;Ocular Physiology;Operative Surgical Procedures;Outcome;Patients;Physiology;Procedures;Process;programs;Property;Research;response;Retrieval;Role;Short-Term Memory;Signal Transduction;Site;Source Code;Stimulus;Structure;System;Techniques;Temporal Lobe;Testing;Time;timeline;Translating;verbal;visual tracking;Work

PROJECT_TITLE: Neuronal mechanisms of human episodic memory


ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

ORG_CITY: ATHENS

ORG_NAME: OHIO UNIVERSITY ATHENS

PHR: Project Narrative Weakness is an important contributor to age-related physical impairments. The proposed research is relevant to public health because it will advance the understanding of the causes of age-related weakness. As such, this application is highly relevant to NIH’s mission of extending healthy living and reducing the burdens of physical disability in old age.

PI_NAMEs: ARNOLD, WILLIAM DAVID;CLARK, BRIAN C (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Accounting;Acute;age related;age-related muscle loss;aged;Aging;Agonist;Animals;Chronic;Clinical;Clinical Research;Cre lox recombination system;Data;design;Dose;Exhibits;experimental study;Extensor;Future;Generations;Genetic;Hand Strength;Health;Human;human data;human old age (65+);indexing;Injury;insight;Intervention;Isotonic Exercise;Leg;Level of Evidence;Link;Longevity;longitudinal design;Longitudinal Studies;Mission;Modeling;Motor;motor disorder;Motor Neurons;Muscle;muscle form;muscle strength;neural;neuromechanism;neuronal excitability;old mice;older adult;pharmacologic;Phenotype;physical impairment;physically handicapped;pre-clinical;Public Health;Rattus;Reporting;Research;response;Rodent;Role;Sepsis;septic;Serotonin;Serotonin Receptor 5-HT2C;Shapes;Tamoxifen;Testing;Thigh structure;Thinness;Translating;treatment strategy;United States National Institutes of Health;Work

PROJECT_TITLE: Neural mechanisms of age-related weakness

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Metastatic breast cancer and relapse following therapy are dependent on (1) development of intrinsic resistance to targeted and endocrine therapies, and (2) resistance to recognition and destruction of cancer cells by the immune system. The Stanford Breast Metastasis Center (SBMC) is focused on (1) quantifying the timing of metastatic dissemination in breast cancer (2) functionally delineating the contribution of cellular and microenvironmental crosstalk on metastatic proclivity, and (3) characterizing the mechanisms of responses by metastatic cells to therapies. To achieve these goals, we harness an integrated systems biology, functional genomic and evolutionary dynamic approach applied to longitudinal breast cancer tissue cohorts and patient- derived organoid models.

PI_NAMEs: CURTIS, CHRISTINA N (contact)

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: 3-Dimensional;Address;bean;biobank;Biological Models;Breast;breast cancer metastasis;Breast Cancer Model;Breast Cancer Patient;breast cancer progression;cancer cell;Cancer Relapse;Cell Communication;Cells;Classification;Clinical;cohort;Collection;computer framework;Computer Models;computerized tools;CRISPR screen;CRISPR/Cas technology;Data;data integration;Dependence;Development;Diagnosis;Disease;disease heterogeneity;ERBB2 gene;Estrogen receptor positive;Experimental Models;functional genomics;genome-wide;Genomic approach;Genomics;Goals;high risk;hormone therapy;Image;Immune;Immune system;In Situ;innovation;invention;Lead;Longitudinal cohort;Machine Learning;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Metastatic breast cancer;Modeling;Molecular;Molecular Profiling;multidisciplinary;Multiplexed Ion Beam Imaging;Nature;Neoplasm Metastasis;neoplastic cell;Non-linear Models;Oncogenic;Organoids;Outcome;Pathologist;Pathology;Patients;Phagocytosis;Population;Primary Neoplasm;Process;Property;prospective;Relapse;relapse risk;Research Project Grants;Research Support;Resistance;Resolution;Resource Sharing;response;Sampling;single cell technology;Site;Spatial Distribution;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Stromal Cells;Subgroup;System;Systems Biology;targeted treatment;Technology;Therapeutic;therapeutic target;therapy resistant;Time;Tissue Model;tissue resource;Tissue Sample;Tissues;triple-negative invasive breast carcinoma;tumor;Tumor Tissue;Vision;Visualization

PROJECT_TITLE: Evolutionary dynamics and microenvironmental determinants of metastatic breast cancer


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

PROJECT_TERMS: Advisory Committees;Advocate;Archives;Bioinformatics;Breast;breast cancer metastasis;Calendar;Cancer Biology;Communication;Communities;Computational Biology;dashboard;Data;data exchange;design;Ensure;Evaluation;Event;experience;flexibility;Fostering;functional genomics;Future;Hearing;Immunology;Interdisciplinary Study;Link;Logistics;Medical Oncology;meetings;Metastatic breast cancer;Methods;Modeling;Monitor;multidisciplinary;Neoplasm Metastasis;Operative Surgical Procedures;organizational structure;Pathology;Patients;Performance;Process;Productivity;programs;Progress Reports;Recommendation;repository;Research;Research Personnel;Resolution;Site;statistics;success;Update;web site;Work;working group

PROJECT_TITLE: Stanford Breast Metastasis Center Administrative Core


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHESTNUT HILL

ORG_NAME: BOSTON COLLEGE

PHR: PROJECT NARRATIVE Health equity is a public health priority and key outcome of the federal initiative to end the HIV epidemic. However, public health professionals lack tools to assess the ability of a given program to produce equitable outcomes. This research will not only address this gap but also make a significant contribution to the public health and health equity landscape through the development of the Health Equitability Assessment and Readiness Tool (HEART). The HEART will be a valid and practical tool used to assess the equitability of public health programs.

PI_NAMEs: IRIE, WHITNEY CHIVONNE (contact)

PROGRAM_OFFICER_NAME: ROE, JOANAD'ARC C

PROJECT_TERMS: Acceleration;Address;AIDS prevention;Assessment tool;Award;Biomedical Research;black men;Black Populations;Black race;black women;Child;Client;Clinical;cognitive interview;Communicable Diseases;Communities;Complex;concept mapping;Conceptual Domain;COVID-19;Data;design;Development;Device or Instrument Development;Disease;disorder prevention;Disparity;Disparity population;Ensure;Epidemic;Equity;Evaluation;Evidence based intervention;flu;Future;Generations;Geography;health equity;health inequalities;Health Priorities;Health Professional;Health system;HIV;Hospitalization;Human Papillomavirus;implementation evaluation;implementation science;improved;Incidence;Inequity;Influenza;innovation;instrument;Intervention;Investments;Link;Longitudinal Studies;Maps;Measurable;Measurement;Measures;Methods;Mission;Monkeypox;Not Hispanic or Latino;Outcome;outcome disparities;Pathway interactions;Policy Maker;population health;Positioning Attribute;premature;Prevalence;prevent;preventable death;Prevention;Principal Investigator;Process;programs;Psychometrics;Public Health;public health priorities;racial disparity;Readiness;Reporting;Reproducibility;Research;Research Design;Research Personnel;Resources;Services;sexual minority;social determinants;Sorting;Structure;Surveys;System;Testing;tool;tool development;United States;usability;Vaccination;Vaccines;Validation;Visualization;White Women

PROJECT_TITLE: HEART Study: Development of the Health Equitability Assessment and Readiness Tool


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Precision Medicine;Women's Health Research

PROJECT_TERMS: 11q13;17q23;8q24;Address;Aftercare;ATAC-seq;Bar Codes;Biological Markers;biomarker driven;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Patient;breast cancer progression;Cancer Relapse;CCND1 gene;CDK4 gene;Cell surface;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clinical;Clinical Data;Clinical Trials;cohort;Collaborations;Colorectal Cancer;Computer Models;Cues;Data;Data Set;Diagnosis;digital;Disease;Distant;EIF4EBP1 gene;Endocrine;Engineering;ERBB2 gene;Estrogen receptor positive;FGF3 gene;FGFR1 gene;Fibroblast Growth Factor Receptors;FRAP1 gene;genomic data;Genomics;glycosyltransferase;HBXAP gene;high risk;hormone therapy;Immune;Immunosuppression;improved;in silico;In Situ;In Vitro;in vivo;inhibitor;Link;Longitudinal cohort;Longterm Follow-up;Lymphocyte;Macrophage;Malignant Breast Neoplasm;Malignant neoplasm of lung;mathematical model;MCF10A cells;Measures;Metastatic breast cancer;Modeling;monocyte;nano-string;Nature;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel therapeutic intervention;Oncogenic;Organoids;overexpression;Patients;Pattern;Polysaccharides;predictive modeling;Primary Lesion;Primary Neoplasm;Prognosis;Progression-Free Survivals;prospective;Proto-Oncogene Proteins c-akt;PVT1 gene;receptor expression;Recurrence;Relapse;relapse risk;Resistance;resistance mechanism;response;RNA;Route;Sampling;Site;spatiotemporal;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Subgroup;targeted sequencing;targeted treatment;Techniques;Testing;Time;Tissues;transcriptomics;treatment response;triple-negative invasive breast carcinoma;tumor;tumor progression;Xenograft procedure

PROJECT_TITLE: Project 1:Evolutionary dynamics and drivers of breast cancer metastasis and relapse


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

PHR: GABAergic dysfunction is strongly associated with autism, schizophrenia and childhood epilepsy. Increasing experimental evidence points towards imbalances between the excitatory and inhibitory circuits in the brain as a prominent component in the etiology of these illnesses. This project is aimed at further our understanding on how electrical activity affects early brain maturation during critical periods of development with an emphasis on cortico-cortical pathways.

PI_NAMEs: DE MARCO GARCIA, NATALIA VANESA (contact)

PROGRAM_OFFICER_NAME: DOSS, ARGENIA LANISHA NECOLE

PROJECT_TERMS: Ablation;Adolescent;Adult;Affect;Anatomy;Angelman Syndrome;Area;ASD patient;autism spectrum disorder;barrel cortex;Behavior;Behavioral;Brain;brain abnormalities;Brain region;Calcium;Cerebral cortex;Child;childhood epilepsy;Cognitive;Contralateral;critical period;Defect;Development;Developmental Process;Disease;Distant;Emergency Situation;Environmental Risk Factor;Equilibrium;Etiology;experimental study;Functional disorder;gamma-Aminobutyric Acid;Genes;Genetic;Genetic Predisposition to Disease;Goals;Head;high risk;Image;Impairment;in vivo;innovation;Interneurons;Ipsilateral;Knowledge;Lead;Motor Cortex;Mus;mutant;Mutation;Neonatal;neonate;neuronal circuitry;Neurons;neuropathology;Outcome;Parietal Lobe;Pathway interactions;Patients;Pattern;Perception;Phenotype;Process;pup;Pyramidal Cells;rabies viral tracing;receptor;Research;Role;Schizophrenia;Sensory;Signal Pathway;Signal Transduction;Somatosensory Cortex;Source;Stimulus;Study models;Techniques;Testing;translational impact;two-photon;Vibrissae;Virus;Work

PROJECT_TITLE: A Circuit Mechanism for the Development of Cortico-cortical Connectivity

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Services

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE In response to an inadequate and declining number of scientists with expertise in clinical research methods, coupled with an increasing recognition of the importance of rigorous epidemiological research, we created an undergraduate research opportunity, the Undergraduate Clinical Scholars Program (UCSP); the program is closely linked with the University of Pennsylvania's world-renowned Center for Clinical Epidemiology and Biostatics, the interdisciplinary home of epidemiology and biostatistics research at Penn. Students receive career mentoring, a comprehensive core curriculum spanning the methods of clinical epidemiology and biostatistics; and participate in structured and mentored research projects the output of which will be abstracts,publications, presentations and applications for next-stage fellowships. Our first five years have shown that early exposure to this rich environment encourages these talented young students to pursue careers in clinicalinvestigation, in line with the NIDDK's missions.

PI_NAMEs: LEWIS, JAMES D (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Address;Admission activity;Advisory Committees;Award;Awareness;Basic Science;Behavioral Sciences;Bioinformatics;Biomedical Research;Biometry;career;Career Choice;Clinical;clinical center;clinical epidemiology;clinical investigation;Clinical Investigator;Clinical Research;Clinical Services;Clinical Trials;cohort;Communication;Comparative Effectiveness Research;Competence;Coupled;COVID-19 pandemic;Decision Making;Decision Modeling;Degree program;design;Development;Diabetes Mellitus;diabetic;disability;disadvantaged background;Discipline;Disease;drug development;Early Intervention;Economics;Educational Curriculum;Educational workshop;Endocrine;Environment;Epidemiology;epidemiology study;Equity;Ethics;experience;Exposure to;Faculty;faculty mentor;Fellowship;Fostering;Funding;Geography;Goals;Graduate Education;graduate school;Health;health economics;Health Services Research;Home;Human;implementation science;improved;Industry;Infrastructure;innovation;Institution;interest;investigator training;Kidney;Knowledge;Laboratories;lectures;Link;Liver;matriculation;Medical;Medical Device;medical schools;Medicine;meetings;member;Mentors;Mentorship;Methods;minority student;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;novel strategies;Observational epidemiology;Outcome;Output;Pancreas;Participant;Pathway interactions;Patients;Peer Review;Pennsylvania;Persons;Pharmacologic Substance;Population;population health;Procedures;programs;Public Health;Public Policy;Publications;Qualifying;Race;recruit;Research;Research Methodology;Research Project Grants;research study;Resources;response;Scholars Program;Scholarship;Science;Scientist;skills;Social Sciences;statistics;Strategic Planning;Structure;student mentoring;student participation;Students;success;summer program;Surveys;symposium;Talents;Training;Translational Research;undergraduate research experience;undergraduate student;Underrepresented Minority;United States;United States Food and Drug Administration;United States National Institutes of Health;Universities;Woman;Work;Workforce Development;Writing

PROJECT_TITLE: Undergraduate Clinical Scholars Program: Pathway to Clinical Research Careers

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


PI_NAMEs: ANGELO, ROBERT MICHAEL (contact)

PROJECT_TERMS: 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine;Antibodies;Automobile Driving;Avidity;Binding;biobank;Biopsy;breast cancer metastasis;breast cancer progression;breast imaging;Cell Communication;cell type;Cells;Clinical;clinically significant;Collagen;collagenase;CRISPR interference;crosslink;Data;Data Set;Deaminase;Disease Progression;Distant;Enzymes;Estrogen receptor positive;Excision;Extracellular Matrix;Family;Fibroblasts;Frequencies;glycosylation;glycosyltransferase;high risk;Hydroxylation;Image;imaging modality;Immune;immune activation;Immune Evasion;Immunosuppression;Invaded;Label;Libraries;Location;Machine Learning;Macrophage;Malignant Breast Neoplasm;Maps;mass spectrometric imaging;Mass Spectrum Analysis;Metabolic;Metals;Metastatic breast cancer;Methods;Mixed Function Oxygenases;Modeling;Modification;Molecular;Morphology;Multiplexed Ion Beam Imaging;Neighborhoods;Neoplasm Metastasis;neoplastic cell;Nivolumab;Normal tissue morphology;Operative Surgical Procedures;Organoids;Outcome;Pathogenesis;Patients;Peptide Hydrolases;Peptides;permissiveness;Play;Polysaccharides;Population;prevent;Process;Procollagen-Proline Dioxygenase;Protein Glycosylation;Proteins;Proteomics;receptor;recruit;Resolution;Resources;response;Risk;Role;Sampling;sialylation;Site;Specimen;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Stains;Stromal Cells;Structure;Testing;Therapeutic;Time;Tissue imaging;Tissue Sample;Tissues;tool;transcriptomics;triple-negative invasive breast carcinoma;tumor;Tumor Cell Migration;tumor microenvironment;Visualization;Work

PROJECT_TITLE: Project 2: Cellular topography and function of the breast cancer tissue microenvironment


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Lung;Mental Health;Neurosciences;Pediatric;Sleep Research

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: Project Narrative  Down syndrome (DS) is one of the most common genetic conditions in the United States with a prevalence rate estimated at 6.7 people with DS per 10,000 of the population in 2010 and is characterized by global developmental delays, intellectual disability, and obstructive sleep apnea (OSA), which can have negative effects on daily life for children with DS. Hypoglossal nerve stimulation (HGS) is a novel therapy for OSA in adults as well as children with preliminary data suggesting improved cognition and language in this population. Therefore, this proposal is a formal clinical trial to focus upon the effects on neurocognition and expressive language before and after hypoglossal nerve stimulation treatment of OSA.

PI_NAMEs: HARTNICK, CHRISTOPHER J (contact);SKOTKO, BRIAN GARY

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: 21 year old;Adolescent;Adult;Age;alternative treatment;Apnea;Attention;Blinded;cardiopulmonary system;Caregivers;Cessation of life;Child;Childhood;Clinical Trials;Cognition;Continuous Positive Airway Pressure;Data;Disease;Down's Syndrome;Ear;Enrollment;executive function;exhaust;Eye;FDA approved;Genetic Diseases;Genetic Transcription;global developmental delay;Goals;Hypoglossal nerve structure;Impairment;Implant;implantation;improved;improvement on sleep;indexing;Intellectual functioning disability;Intelligence;Language;Language Tests;Life;life span;Link;Masks;Massachusetts;Measures;memory consolidation;Motor;Neurocognition;Neurocognitive;neurocognitive test;non-compliance;novel;novel therapeutics;Obstructive Sleep Apnea;Operative Surgical Procedures;Outcome;Outcome Measure;Outcome Study;Parents;Patients;pediatric patients;Persons;Phase;Phase I Clinical Trials;Pilot Projects;Population;Postoperative Period;Prevalence;primary outcome;Procedures;processing speed;Pulmonary Heart Disease;Quality of life;recruit;Reporting;Research Personnel;Safety;Sample Size;Sampling;Schools;Sensory;Severities;Site;skills;Sleep;sleep quality;Speech;standard measure;Surveys;sustained attention;syntax;Tail;Testing;Tongue;United States;verbal;Vocabulary

PROJECT_TITLE: Effects of Hypoglossal Nerve Stimulation on Cognition & Language in Down Syndrome

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]