NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Pediatric;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: BALTIMORE

ORG_DEPT: GENETICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Narrative Tibetan refugees have extreme TB rates and >50% of the cases occur in boarding schools and monasteries. I propose to study TB epidemiology, transmission, and preventive therapy outcome in these settings by analyzing epidemiologic, spatial, and whole genome sequencing data for children and young adults.

PI_NAMEs: DORJEE, KUNCHOK  (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: acquired factor;Adolescent;Adolescent and Young Adult;Award;Behavioral;Biological Assay;burden of illness;case finding;Child;Communicable Diseases;Communities;Data;data exchange;data modeling;Demography;Disease;Disease Progression;disorder risk;epidemiologic data;Epidemiology;epidemiology study;experience;follow-up;Funding;genome sequencing;genomic data;Genomics;Goals;hazard;Health;Hospitals;Household;Incidence;India;Infection;Institution;Interruption;Intervention;isoniazid;Knowledge;Link;Maps;mathematical model;Medical History;Mentorship;Methodology;Methods;Molecular Epidemiology;Multicenter Studies;Nature;novel;Outcome Study;Participant;Pathway Analysis;Persons;Pharmaceutical Preparations;Phylogenetic Analysis;Population;Predisposition;Prevalence;Prevention;Prevention strategy;Preventive therapy;programs;Public Health;Pulmonary Tuberculosis;Refugees;Research;Research Personnel;Resistance;Rifampin;Risk;Risk Factors;routine screening;scale up;Schools;screening;Sequence Analysis;side effect;Single Nucleotide Polymorphism;skill acquisition;social;Social Network;Specimen;study characteristics;Symptoms;Testing;therapy outcome;Thoracic Radiography;tool;Training;transmission process;Travel;Tuberculin Test;Tuberculosis;Universities;Vulnerable Populations;whole genome;young adult

PROJECT_TITLE: Tuberculosis Transmission and Preventive Therapy in Tibetan Children and Young Adults in India

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cerebrovascular;Clinical Research;Complementary and Integrative Health;Dietary Supplements;Neurosciences;Nutrition;Precision Medicine;Prevention;Stroke;Women's Health Research

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Proteomic approaches may identify novel precursors of disease and targets for drug therapy. This grant will measure 3072 proteins to test and validate their association with risk of ischemic stroke using five cohorts and will conduct integrative proteomic data and previously measured metabolomic and biomarker data. Discovery of proteins and molecular markers that are involved in the development of stroke could ultimately lead to new approaches for prevention of stroke in the general population.

PI_NAMEs: REXRODE, KATHRYN M (contact)

PROGRAM_OFFICER_NAME: PRICE, CANDICE

PROJECT_TERMS: adipokines;adjudication;adrenomedullin;Alleles;Arteries;biobank;Biological;Biological Markers;Biological Process;Cardiovascular Diseases;Cause of Death;CD95 Antigens;Cessation of life;Classification;cohort;Cohort Studies;Coronary heart disease;cost;Creativeness;CSF1 gene;Data;design;Development;disability;Disease;Documentation;Etiology;Evaluation;follow-up;Framingham Heart Study;GDF15 gene;General Population;Genetic;Goals;Gonadal Steroid Hormones;Grant;Health;improved;Incidence;Inflammation;innovation;Interleukins;Ischemic Stroke;lifestyle data;Long term disability;Longitudinal cohort;Matrix Metalloproteinases;Measures;Medical Records;men;Mendelian randomization;Meta-Analysis;metabolomics;Methods;molecular marker;multiple omics;National Heart, Lung, and Blood Institute;new therapeutic target;novel;novel strategies;Nurses' Health Study;offspring;Omega-3 Fatty Acids;Participant;Pathway interactions;Phenotype;Population;Prevention strategy;pro-brain natriuretic peptide (1-76);prospective;protein biomarkers;protein function;Proteins;Proteome;Proteomics;Race;receptor;Research;Risk;Risk Factors;risk variant;sex;Stroke;stroke incidence;Stroke prevention;success;Surface;targeted treatment;Techniques;Testing;Tissues;Urokinase;Validation;Vasodilation;Vitamin D;Woman;Women's cohort;Women's Health;Women's mortality;Women's trial;Work

PROJECT_TITLE: Risk Factors for Ischemic Stroke in Women

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: High-risk neuroblastoma remains an incurable disease with an urgent need for the identification of novel therapeutic targets and design of novel therapeutics. In our preliminary studies, we used a CRISPR-based knockout screening and identified CAMKV kinase, a novel member of serine/threonine kinase (CAMK) family, as an important mediator of an oncogenic signaling pathway in neuroblastoma cells. In this research proposal, we aim to determine the role of CAMKV kinase activity in neuroblastoma development in mouse models and the therapeutic potential of CAMKV inhibition by knockout/knockdown as well as its small molecule inhibitors for treating neuroblastoma and overcoming chemotherapy resistance in preclinical animal models.

PI_NAMEs: YANG, JIANHUA  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Animal Model;biological heterogeneity;Biological Markers;Ca(2+)-Calmodulin Dependent Protein Kinase;Calcium;Cell Line;Cell Proliferation;Cephalic;Cessation of life;Chemoresistance;chemotherapeutic agent;Child;clinical heterogeneity;Clustered Regularly Interspaced Short Palindromic Repeats;conditional knockout;CREB1 gene;Defect;design;Development;Disease;Disease Outcome;Dose;experimental study;Family;Goals;Growth;high risk;improved;in vivo;Inhibition of Cell Proliferation;inhibitor;innovation;K 252a;knock-down;Knock-out;Knockout Mice;Malignant - descriptor;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediator;member;Molecular;mouse development;mouse model;MYCN gene;Neuroblastoma;neuroblastoma cell;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;overexpression;Patient-Focused Outcomes;Pediatric Neoplasm;Phosphorylation;Phosphotransferases;Play;pre-clinical;Protein-Serine-Threonine Kinases;Proteins;Recurrence;Refractory;Regimen;Regulation;Research;Research Proposals;Role;Sampling;screening;Serine;Signal Pathway;Signal Transduction;small molecule inhibitor;Solid Neoplasm;Somatic Mutation;Stimulus;Testing;Therapeutic;therapy design;transcription factor;Transgenic Mice;Transgenic Model;Transgenic Organisms;tumor;tumor growth;Tumor Promotion;tumorigenesis;Vesicle;Work;Xenograft procedure

PROJECT_TITLE: CAMKV Kinase Signaling in Neuroblastoma

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: SAINT LOUIS

ORG_DEPT: PATHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The activation of CD8 T cells against pathogens and tumors requires the activity of a specific type of dendritic cell, called cDC1, which captures antigens that interact with the T cell receptor of the CD8 T cell. However, cDC1 must first be “licensed” in order to be able to activate CD8 T cells for effective responses against pathogens or tumors. The process of DC licensing is incompletely understood, and our published and preliminary data indicate that our current models are incomplete. This proposal aims to define novel pathways activated by Batf3 and CD40 signaling responsible for DC licensing and the cell types capable of initiating this process.

PI_NAMEs: MURPHY, KENNETH M (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Antigen Presentation;Antigen-Presenting Cells;Antigens;Antitumor Response;arm;Cardiolipins;CD4 Positive T Lymphocytes;CD40 Ligand;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Communication;cell type;Cells;Cross Presentation;Data;Dendritic Cells;Development;Enhancers;Exclusion;Gene Deletion;Genes;Helper-Inducer T-Lymphocyte;in vivo;Individual;Knowledge;Licensing;Ligands;Lipids;Methods;Modeling;Mus;Nature;neoantigens;new therapeutic target;novel;pathogen;Pathway interactions;Process;programs;Publishing;response;Role;Signal Induction;Signal Transduction;Source;T cell response;T-Cell Receptor;T-Lymphocyte;Testing;Time;TNFRSF5 gene;TNFSF5 gene;transcription factor;transgene expression;tumor;Tumor Immunity;Tumor Promotion;Tumor-Derived;Virus;Work;γδ T cells

PROJECT_TITLE: Understanding the Mechanisms of DC Licensing in CD8 T Cell Priming

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it seeks to advance understanding of the biology of DNA break formation and repair in neurons of the mature brain, which has important implications for cognitive function, aging, and brain disorders that cause significant human suffering and a serious economic burden. The proposed project is relevant to NIH's mission because the expected results will increase fundamental knowledge about the brain and form the basis for strategies to improve brain health in the long term.

PI_NAMEs: SCHWER, BJOERN  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: 3-Dimensional;Address;Affect;Age;age related;age related changes;Age-associated memory impairment;Aging;aging brain;aging related;Animals;awake;Biological Assay;Biology;Brain;Brain Diseases;brain health;cell type;Cells;Cerebral cortex;Chromatin Structure;cognitive function;Dementia;Detection;Development;Disease;DNA;DNA Double Strand Break;DNA Repair;DNA Sequence Alteration;Double Strand Break Repair;Economic Burden;Electrophysiology (science);Epigenetic Process;epigenome;epigenomics;ERG gene;Future;Gene Expression;Gene Expression Profile;Genes;genetic approach;genetic manipulation;Genome;Genome Stability;Genomics;Goals;Head;Hippocampus;Histologic;Homeostasis;Human;Impaired cognition;improved;In Vitro;Induced Neurons;innovation;innovative technologies;insight;interdisciplinary approach;Knowledge;life span;Maintenance;Maps;Mediating;Mission;Modeling;Mosaicism;multidisciplinary;Mus;Natural regeneration;Nerve Degeneration;neural;neural circuit;neurobehavioral test;Neurobiology;Neurodegenerative Disorders;Neuronal Plasticity;Neurons;neurophysiology;Neurophysiology - biologic function;Nonhomologous DNA End Joining;old mice;Optics;Organizational Change;Pathway interactions;Phenotype;Physiological;Physiology;Positioning Attribute;postmitotic;prevent;Prevention;Process;Public Health;repaired;Research;Research Proposals;Role;single cell genomics;Sleep;Structure;targeted sequencing;Techniques;Technology;Testing;theories;therapeutic development;therapeutically effective;Time;tool;transcriptome;United States National Institutes of Health

PROJECT_TITLE: Role of DNA double-strand breaks in neural function and homeostasis

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Project Narrative Metalloenzymes perform challenging but essential transformations of inert chemical bonds in biological systems. We seek a unified understanding of how four different metalloenzyme superfamilies control reaction outcomes. These efforts will enable enzyme engineering or targeting for inhibition in pathogens.

PI_NAMEs: BOAL, AMIE K (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Biological;biological systems;chemical bond;chemical reaction;Chemicals;cofactor;comparative;DNA biosynthesis;drug synthesis;Drug Targeting;Engineering;Environment;Enzyme Inhibition;Enzymes;Family;Friends;Maps;metalloenzyme;Metals;Modification;novel;Outcome;pathogen;pathogenic bacteria;Process;Reaction;Route;Structure;System;Technology;tool;Trace Elements;Transition Elements;Work

PROJECT_TITLE: Mapping the structural basis for mechanistic diversity in metalloenzyme superfamilies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Physical Activity;Prevention;Women's Health Research

ORG_CITY: MILWAUKEE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: MARQUETTE UNIVERSITY

ORG_STATE: WI

PHR: PROJECT NARRATIVE  Advanced age is accompanied by weaker and more fatigable limb muscles making it difficult for older men and especially women (≥65 years) to generate the power necessary to perform daily activities. The proposed studies will address this issue and identify potential sex differences by determining whether the greater fatigability of older adults performing dynamic contractions is due to impaired skeletal muscle bioenergetics and/or vascular dysfunction. Furthermore, we will conduct a clinical trial testing the effectiveness of coupling high-velocity resistance exercise with blood flow restriction of the limb to improve function, power and fatigability in older men and women.

PI_NAMEs: FITTS, ROBERT H;HUNTER, SANDRA K;SUNDBERG, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: active lifestyle;age related;age-related disease;Aging;aging population;arteriole;ATP phosphohydrolase;Atrophic;Bioenergetics;Biopsy;Blood flow;Blood Vessels;Ca(2+)-Transporting ATPase;Cardiovascular Diseases;clinical development;clinical translation;Clinical Trials;clinically relevant;clinically significant;Coupled;Couples;Coupling;Development;Diabetes Mellitus;Disease;Doppler Ultrasonography;Educational Intervention;effectiveness evaluation;effectiveness study;effectiveness testing;efficacy testing;Elderly;Exercise;exercise program;exercise training;Extensor;Fatigue;femoral artery;Fiber;Functional disorder;functional improvement;Goals;Healthcare;human old age (65+);Hydrogen;Impairment;improved;improved mobility;In Vitro;in vivo;inorganic phosphate;insight;Intervention;Knee;Knowledge;Leg;Life;Limb structure;Lower Extremity;Measures;mechanical stimulus;Metabolic;Microscopy;Muscle;muscle form;Muscular Atrophy;Near-Infrared Spectroscopy;NMR Spectroscopy;novel;older adult;older men;older women;Perfusion;Physiology;protective effect;quadriceps muscle;Quality of life;resistance exercise;risk mitigation;sarcopenia;Sarcoplasmic Reticulum;Sex Differences;Skeletal Muscle;Techniques;Testing;tissue oxygenation;Training;Training Programs;Translating;Vascular Diseases;vastus lateralis;Video Microscopy;Woman;young adult

PROJECT_TITLE: Fatigability of Limb Muscle in Older Adults: Protective Effects of Exercise

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases

ORG_CITY: DURHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Prolonged injury to the pancreas causes pancreatic fibrosis and is associated with an increased risk of pancreatic cancer. We recently discovered that pancreatic stellate cells, which are the source of fibrosis, react to pressure through the mechanically-activated ion channel, Piezo1. The current proposal will determine if blocking Piezo1 prevents stellate cell activation and protects against pancreatic fibrosis. These studies could lead to new therapies for chronic pancreatitis.

PI_NAMEs: LIDDLE, RODGER A. (contact)

PROGRAM_OFFICER_NAME: ANDERSEN, DANA K

PROJECT_TERMS: Acinar Cell;acute pancreatitis;Agonist;Cations;Cell secretion;Cell surface;Cells;Chronic;chronic pancreatitis;Cicatrix;Circulation;Collagen;Common bile duct structure;Data;Deposition;Development;direct application;Duct (organ) structure;Ductal Epithelial Cell;Endocrine;Exhibits;Exocrine pancreas;Extracellular Matrix;Extracellular Matrix Proteins;Fibrosis;Generations;Genetic;Gland;Inflammation;injured;Injury;insight;Investigation;Ion Channel;islet;Islet Cell;Link;Malignant neoplasm of pancreas;mechanical force;Mechanics;Mediating;Modeling;Molecular;Mus;Natural regeneration;novel;novel therapeutics;Nuclear;Obstruction;Pancreas;pancreas development;Pancreatic duct;Pancreatic Injury;pancreatic juice;pancreatic stellate cell;Pathogenesis;Pathway interactions;Physiological;Piezo 1 ion channel;pressure;prevent;protective pathway;Proteins;Reaction;receptor;Recurrence;response;Retinoids;Risk;Role;Signal Pathway;Source;stellate cell;Tissues

PROJECT_TITLE: Mechanisms of Pancreatic Fibrosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-A(90)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Prevention;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PUBLIC HEALTH RELEVANCE: In recent years, severe outbreaks and epidemics of Ebola, Lassa, and Zika have illustrated how vulnerable the world is to threats from RNA viral pathogens. To counter the dangers posed by these viruses, we must develop flexible and scalable technologies for diagnostics, surveillance, pathogen discovery and transmission, and deploy them in the most outbreak-prone regions of the world. Here, we will establish the West African Research Network for Infectious Diseases with partners in the United States, Senegal, Sierra Leone, Liberia, and Nigeria, to develop effective strategies, and deploy the necessary tools, for detecting, mitigating, and preventing future outbreaks from emerging and re-emerging infectious diseases.

PI_NAMEs: ANDERSEN, KRISTIAN GRAUGAARD (contact);GARRY, ROBERT F;SABETI, PARDIS CHRISTINE

PROGRAM_OFFICER_NAME: WOODSON, SARA ELAINE

PROJECT_TERMS: Acceleration;Acute;Affect;Africa;African;Animals;Area;Awareness;Biological Assay;Chiroptera;Clinical;Clinical Management;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collaborations;Communicable Diseases;Communication;Communities;computerized tools;Country;data sharing;Decentralization;Detection;Development;Diagnostic;diagnostic assay;diagnostic criteria;diagnostic technologies;Diagnostic tests;diagnostic tool;Disease Outbreaks;Ebola;Educational workshop;Emerging Communicable Diseases;emerging pathogen;emerging virus;Ensure;Epidemic;Epidemiologist;Evolution;experience;flexibility;Foundations;Frequencies;Funding;Future;future outbreak;future pandemic;genome sequencing;Genomics;Goals;Health;Human;Immune response;improved;Infection;Infectious Diseases Research;Infrastructure;Knowledge;Lassa;Lassa virus;Liberia;metagenomic sequencing;Metagenomics;Methods;microbial;Molecular Epidemiology;National Institute of Allergy and Infectious Disease;Natural History;new outbreak;new technology;Nigeria;novel;Outcome;pandemic potential;pandemic preparedness;pathogen;Pathogenesis;pathogenic virus;Patients;Persons;Prevalence;prevent;Prevention strategy;priority pathogen;Protocols documentation;Public Health;public health emergency;public health intervention;public health relevance;Rapid diagnostics;Reaction;Reagent;Research;Research Personnel;response;Risk;Risk Factors;RNA;RNA Viruses;Rodent;Security;Senegal;Sierra Leone;Standardization;Surveys;System;technology development;Technology Transfer;Testing;tool;Training;transmission process;United States;United States National Institutes of Health;Viral Hemorrhagic Fevers;viral transmission;Virus;Virus Diseases;Work;World Bank;ZIKA

PROJECT_TITLE: West African Emerging Infectious Disease Research Center (WA-EIDRC)


NIH_SPENDING_CATS: Asthma;Biotechnology;Clinical Research;Health Effects of Indoor Air Pollution;Immunization;Immunotherapy;Lung;Vaccine Related

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: INDOOR BIOTECHNOLOGIES

ORG_STATE: VA

PHR: PROJECT NARRATIVE IgE sensitization to house dust mites and other indoor allergens is associated with development of asthma, a disease that affects 26 million people in the U.S. Monoclonal IgE antibodies specific for asthma-associated allergens will be isolated for the first time as they occur in vivo, to analyze IgE antibody epitopes on group 1 and 2 mite allergens and their associated IgE antibody repertoire. The goal is to elucidate the importance of the intrinsic properties of these allergens on their role in causing allergic disease, and to produce hypoallergenic mutants that will be tested for B and T cell reactivity, to generate information that will facilitate a rational design of mite allergy vaccines.

PI_NAMEs: CHAPMAN, MARTIN D.;CHRUSZCZ, MAKSYMILIAN ;POMES, ANNA  (contact)

PROGRAM_OFFICER_NAME: LIN, ADORA ASHELY

PROJECT_TERMS: Accident and Emergency department;Admission activity;Affect;Allergens;Allergic;Allergic Disease;Amino Acids;Antibodies;Antibody Repertoire;Antibody Response;Asthma;asthmatic;asthmatic patient;Award;B-Lymphocyte Epitopes;B-Lymphocytes;Binding;Biological Assay;Canis familiaris;Caspase;Cells;Characteristics;Child;Clinical Research;cockroach allergen;combinatorial;Complex;Crystallization;cytokine;Data;Data Set;Databases;Dermatophagoides farinae antigen f 1;Dermatophagoides pteronyssinus antigen p 1;Dermatophagoides pteronyssinus antigen p 2;design;Development;Dictyoptera;Disease;dust mite allergy;Engineering;Epitope Mapping;Epitopes;Felis catus;Funding;Future;Goals;Grant;Health;Homologous Gene;House Dust Mite Allergens;Human;Hybridomas;Hypersensitivity;IgE;Immune;Immune response;Immunoassay;Immunoglobulin G;Immunologics;immunoreactivity;Immunotherapeutic agent;Immunotherapy;immunotherapy trials;impaired capacity;improved;in vivo;indoor allergen;Innate Immune System;inner city;innovation;Libraries;Light;lipopolysaccharide-binding protein;Mammalian Cell;Maps;Mediator;Mites;Molecular;Molecular Conformation;Monoclonal Antibodies;Multiple Myeloma;Mus;mutant;Mutate;Nuclear Magnetic Resonance;Patients;Persons;Phage Display;Phase;Play;Prevalence;Property;Pulmonary Inflammation;Pyroglyphidae;rational design;Recombinant Antibody;Recombinant Proteins;Recombinants;Reporting;response;Risk Factors;Role;Site-Directed Mutagenesis;Source;Specificity;Structure;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;Technology;Testing;three dimensional structure;Time;Toll-like receptors;tool;Vaccine Design;vaccine immunotherapy;Vaccines;Variant;X-Ray Crystallography

PROJECT_TITLE: Antigenic determinants of asthma-associated allergens for design of immunotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(57)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Trans-ancestry genetic analysis can facilitate genomic discoveries and is critical for equal delivery of precision healthcare globally. However, current trans-ancestry genetic research is impeded by limited genomic resources for non-European populations and inadequate statistical methods that can appropriately model and analyze data from ancestrally diverse populations. This project will address these challenges by aggregating and harmonizing data from large-scale biobanks across the globe, and developing novel statistical methods that can integrate data from multiple populations for improved trans-ancestry genetic studies.

PI_NAMEs: GE, TIAN  (contact)

PROGRAM_OFFICER_NAME: ZHANG, LI

PROJECT_TERMS: All of Us Research Program;Architecture;Benchmarking;biobank;Biological;biomarker performance;Calibration;causal variant;Clinical;comparative;Complex;Computer software;Data;Data Aggregation;data harmonization;data integration;Data Linkages;Data Set;Disease;disorder risk;Electronic Health Record;epidemiology study;Ethnic Origin;Evaluation;experience;flexibility;Future;Genes;Genetic;genetic analysis;genetic architecture;genetic predictors;Genetic Research;Genetic study;genetic variant;genome resource;genome wide association study;genome-wide;genomic locus;Genomics;Haplotypes;Health;Healthcare Systems;Human;improved;Japan;Knowledge;Koreans;Laboratories;large scale data;Link;Linkage Disequilibrium;Maps;Measures;Medicine;Meta-Analysis;method development;Methods;Modeling;novel;open source;Pattern;personalized health care;polygenic risk score;Population;population based;Population Genetics;Population Heterogeneity;portability;Research Design;Resolution;Resources;risk prediction;Sample Size;Sampling;simulation;Statistical Methods;statistics;Taiwan;Testing;training data;trait;United States;Universities;Validation;Variant;Weight;Work

PROJECT_TITLE: Improving Methods and Practices for Trans-Ethnic Genetic Studies

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative The proposed studies will investigate a novel aspect of prohibitin (PHB) in that the function of this important protein is dictated by the cellular environment. This form of functional regulation is directly related to its role in the ischemic neuronal injury and on mitochondrial functions. The findings will advance our understanding of the fundamental processes governing neuronal survival and death through regulation of mitochondrial functions, and have the potential of identifying mitochondria targeted treatment strategies for stroke and other neurological diseases linked to mitochondrial dysfunction.

PI_NAMEs: ZHOU, PING  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Address;Affect;artery occlusion;Astrocytes;Binding;Bioenergetics;Biological Assay;Brain;Brain Injuries;Brain Pathology;brain tissue;cell type;Cells;Cerebral Ischemia;Cerebrum;Coculture Techniques;Code;Crista ampullaris;Cysteine;deprivation;design;Electron Microscopy;Embryo;Environment;Event;Gel;Genus Hippocampus;Glucose;In Vitro;in vivo;inhibitor;Ischemia;Ischemic Brain Injury;ischemic injury;Ischemic Neuronal Injury;Knock-in;Knock-in Mouse;Laboratories;Life;Link;Maintenance;Mediating;Messenger RNA;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modeling;Molecular;Mus;mutant;Mutant Strains Mice;Mutate;Mutation;Nervous System Disorder;Neuroglia;Neurologic;neuron loss;neuronal survival;Neurons;neuroprotection;Nitric Oxide;Nitric Oxide Donors;novel;Oxidative Phosphorylation;Oxygen;Pathology;Patients;Pattern;Phosphorylation;Play;Positioning Attribute;Post-Translational Protein Processing;prevent;Process;Production;prohibitin;protein protein interaction;Protein S;Proteins;Reactive Oxygen Species;Regulation;Respiratory Chain;restoration;Role;S-Nitrosoglutathione;Scaffolding Protein;Somatic Mutation;Specificity;Stress;Stroke;stroke risk;Structure;System;targeted treatment;Testing;Therapeutic;therapy design;Transgenic Mice;translational potential;treatment strategy;Work

PROJECT_TITLE: Role of Prohibitin Nitrosylation in its Neuroprotective Functions

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Digestive Diseases;HIV/AIDS;Hepatitis;Hepatitis - B;Immunization;Infectious Diseases;Liver Disease;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE The proposed research will develop a single LC/MS-based platform that allows for discovery proteomics as well as the targeted analysis of immune system-relevant protein groups requiring less material and less time than previous methods. Such assay will enable us to establish molecular immune profile with hundreds of protein analytes even from the most vulnerable populations such as premature newborns or frail elderly adults, for whom samples availability is often extremely limited. These immune profiles of unprecedented resolution will enable faster response to challenges to the immune system such as infections and will inform a more rational approach to designing vaccines that work in all age groups.

PI_NAMEs: STEEN, HANNO  (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Adolescent;Adult;age group;Agreement;Aliquot;anti-hepatitis B;Antibodies;Antibody titer measurement;Autoimmunity;Bacterial Infections;Biological Assay;biomarker identification;Blood Plasma Volume;Blood Volume;Boston;C-reactive protein;Cells;clinical biomarkers;cohort;Communicable Diseases;Communities;Complement;complement pathway;complement system;Consumption;Data;Development;Disease;Elderly;Erythrocyte Sedimentation Rate;experimental study;Frail Elderly;Funding;Funding Opportunities;Future;gene product;Health;Hepatitis B Surface Antigens;Hepatitis B Vaccination;Hepatitis B Vaccines;Human;Human body;Hypersensitivity;Immune;immune function;Immune response;Immune system;Immunity;immunodeficiency;Immunoglobulin Domain;Immunoglobulins;Immunologic Monitoring;immunological status;Immunology;immunoregulation;improved;Individual;Infant;Infection;innovation;insight;interest;liquid chromatography mass spectrometry;Maps;Measures;Methods;milliliter;Modality;Molecular;Monitor;Mycoses;nanolitre;National Institute of Allergy and Infectious Disease;Neonatal;Newborn Infant;novel;Organism;Parasitic infection;Participant;Patients;Pediatric Hospitals;Persons;Plasma;Plasma Proteins;Population;Populations at Risk;Predisposition;premature;Preparation;preterm newborn;Prevention;procalcitonin;Proteins;Proteome;Proteomics;Regulation;Research;Research Design;Resolution;response;Sampling;Serology;Serum;Set protein;Specimen;System;Systems Biology;Term Birth;Testing;Time;Transplantation;Vaccine Design;vaccine immunogenicity;vaccinology;Virus Diseases;Vulnerable Populations;Work

PROJECT_TITLE: High-throughput proteomics using submicroliter amounts of plasma for comprehensive assessment of the immune status


ORG_CITY: TUCSON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on discovering and characterizing the evolutionarily conserved mechanisms that control the behaviors of centrosomes and their assembly -- processes that, when dysfunctional, contribute to ciliopathy, birth defects and tumorigenesis. Thus, the project is relevant to a part of the NIH's mission because it will enhance our knowledge as to the etiology of numerous centrosome- related human diseases.

PI_NAMEs: ROGERS, GREGORY CHARLES (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Behavior Control;Biological Models;cancer cell;Cell Cycle;Cells;Centrioles;Centrosome;Cilia;ciliopathy;Congenital Abnormality;Daughter;Drosophila genus;Drosophila polo protein;Elements;Equipment and supply inventories;Etiology;Eukaryotic Cell;Explosion;fascinate;functional genomics;Funding;Goals;Growth;human disease;Image;Knowledge;Length;Malignant Neoplasms;Microtubules;Mission;Mitotic;Mitotic spindle;Molecular;Mothers;Organelles;overexpression;Pathology;Phosphorylation;Phosphotransferases;PLK1 gene;prevent;Procentriole;Process;programs;protein complex;Proteins;Proteomics;Public Health;Publishing;recruit;Regulation;Research;restraint;Series;Shapes;Site;Structure;tumorigenesis;Ubiquitination;United States National Institutes of Health

PROJECT_TITLE: Characterizing the molecular mechanisms of centriole duplication, growth and maturation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention;Primary Health Care;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: The US continues to grapple with an opioid epidemic, with close to 70,000 opioid overdose deaths in 2020. This project will test whether combining machine-learning based overdose risk prediction tools with simple behavioral ‘nudge’ interventions in the electronic health record can improve clinician prescribing behavior to reduce overdose risk. If successful, the project will demonstrate how risk prediction can help target low cost and scalable interventions to reduce overdose risk, opening the door to larger scale implementation and substantial public health benefit.

PI_NAMEs: GELLAD, WALID F. (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Accountability;Address;algorithmic bias;Algorithms;Area;arm;Behavior;Behavioral;Benzodiazepines;Calibration;Caring;Classification;Cluster randomized trial;cost;Coupled;design;Discrimination;dosage;Dose;effectiveness evaluation;Electronic Health Record;Epidemic;experience;Face;Focus Groups;Foundations;Funding;Goals;gradient boosting;Health Benefit;health care settings;Health system;high risk;high risk population;improved;Individual;innovation;Intervention;Machine Learning;machine learning algorithm;machine learning prediction;Malignant Neoplasms;Methods;milligram;Modeling;Morphine;mortality risk;Naloxone;National Institute of Drug Abuse;novel strategies;Opioid;opioid epidemic;opioid misuse;opioid mortality;opioid overdose;Outcome;Overdose;Overdose reduction;overdose risk;patient health information;Patient risk;Patients;Performance;Phase;pilot test;Population;prediction algorithm;predictive tools;prescription opioid;prevent;primary care practice;primary outcome;provider behavior;Public Health;Qualifying;Randomized;response;Risk;Risk Factors;risk prediction;Risk Reduction;Safety;secondary analysis;statistics;Substance Use Disorder;success;synergism;Testing;Time;tool;treatment as usual;United States;usability;Work

PROJECT_TITLE: Machine-Learning Prediction and Reducing Overdoses with EHR Nudges (mPROVEN)

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: AMES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: PROJECT NARRATIVE  Oral drug delivery via the mucosal route is considered to have practical advantages, including reduced need for trained medical personnel, cost efficiency, and increased safety. While progress has been made increasing stability and innate activation of potential mucosal drugs, significant knowledge gaps exist at the intercellular and intracellular levels, which leaves poor understanding of the specific and non-specific factors determining recognition and transport of drug candidates across the intestinal epithelia. The proposed research is relevant to the NIBIB's mission because that understanding how nanoparticles-based oral drug delivery systems transport through intestinal epithelium and how the transport behavior can be manipulated through surface modification to create guided transport pathways through intestinal epithelium will provide fundamental and essential knowledge on future design and development of effective drug delivery systems for oral administration.

PI_NAMEs: WANG, QUN  (contact)

PROGRAM_OFFICER_NAME: CHEN, JERMONT

PROJECT_TERMS: Antigens;Behavior;Biological;cell attachment protein;Cells;Chemistry;clinical application;clinical practice;Coculture Techniques;Communicable Diseases;Cost efficiency;Data;design;Development;Disease;drug candidate;Drug Delivery Systems;Drug Targeting;Drug Transport;Encapsulated;Epithelium;Friends;Future;Glean;Goals;Gut Mucosa;Harvest;Health Personnel;Immune response;Immunological Models;improved;in vivo;Inflammatory;insight;intestinal barrier;intestinal epithelium;Intestinal Mucosa;Intestines;Intravenous infusion procedures;Knowledge;Learning;Liposomes;M cell;Mammalian Orthoreovirus;Mediating;Methods;Mission;Modeling;Modification;monolayer;mucosa-associated lymphoid tissue;Mucosal Immune System;Mucous Membrane;Mutation;nanocage;nanoGold;nanoparticle;National Institute of Biomedical Imaging and Bioengineering;Oral;Oral Administration;Organ;Organoids;Outcome;Pathway interactions;Patients;Peyer's Patches;Pharmaceutical Preparations;Phycoerythrin;Polymers;Productivity;Proteins;Publishing;rational design;Research;Research Design;Route;Safety;Solid;stem cells;Subcutaneous Injections;Surface;synergism;targeted delivery;Testing;Training;translational impact;Transport Process;Transportation;treatment response;uptake;Vaccines;Virus-like particle

PROJECT_TITLE: Rational Design of Oral Drugs Targeting Mucosa Delivery

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: ATLANTA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative The research outlined in this proposal will determine if atypical opsins and their stimulation by blue or violet light influence the development of oxygen-induced retinopathy, and whether controlling the spectral composition of light that neonates are exposed to may offer a non- invasive treatment to prevent or diminish the severity of retinopathy of prematurity.

PI_NAMEs: BOATRIGHT, JEFFREY H;IUVONE, P MICHAEL (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Affect;Age related macular degeneration;Air;Blindness;Blood capillaries;Blood Vessels;Caring;Cells;Clinical;Contrast Sensitivity;Data;density;Detection;Development;Diabetic Retinopathy;Disease;Dopamine;experience;experimental study;Exposure to;Eye;Eye Development;Female;Gene Deletion;Histology;Homeostasis;Incubators;Infant;innovation;KDR gene;Knock-out;Knockout Mice;Light;Lighting;male;melanopsin;Modeling;mouse model;Mus;Mutant Strains Mice;Nature;Neonatal;neonatal care;neonate;neovascularization;neurodevelopment;Neurons;Opsin;Outcome Measure;Oxygen;Oxygen Therapy Care;Pathologic Neovascularization;Pathway interactions;Perinatal;perinatal period;Phototherapy;Physicians;postnatal;Predisposition;Pregnancy;Premature Infant;prenatal;prevent;Preventive treatment;Protocols documentation;Research;response;Retina;Retinal Diseases;Retinal Ganglion Cells;Retinal Pigments;Retinopathy of Prematurity;Risk;Role;Severities;Signal Transduction;supplemental oxygen;Testing;Vascular Endothelial Growth Factors;VEGFA gene;Vertebrate Photoreceptors;Viola;Vision;Visual Acuity

PROJECT_TITLE: Atypical opsins and the OIR model of retinopathy of prematurity

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Genetics

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative This project examines the genetic and molecular mechanisms responsible for the diversity of living things. This diversity includes variation within a species as well as between species. This work will improve public health because understanding how phenotypic differences arise on both evolutionary and developmental timescales provides insight into the origin and effects of genetic and molecular changes that impact not only normal trait variation, but also disease.

PI_NAMEs: WITTKOPP, PATRICIA JEAN (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TITLE: Genetic mechanisms and evolutionary processes underlying diversity within and between species

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE MARC at the University of Colorado Denver prepares undergraduate students from groups underrepresented in the biomedical sciences for doctoral programs in academic biomedical research through skills-based in-class learning and on and off-campus research experiences. Diversity in the Ph.D. workforce in higher education and research settings contributes to biomedical advances, to economic growth in a global, knowledge-based economy, and to addressing the needs of underrepresented communities regarding health-related research. Programs that are wholistic (knowledge, research, communication, professional, and wellness skills-based) and interdisciplinary (including behavioral and biomedical focuses) can best prepare future scientists with sophistication and resiliency in research careers that study and address complex health challenges.

PI_NAMEs: ALLEN, RICHARD M (contact);FLORES, SONIA CASTRO

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Address;Bachelor's Degree;base;Biomedical Research;career;career development;CCL7 gene;Color;Colorado;Communication;Community Healthcare;Degree Completion;Development;Disparity;Educational Status;Eligibility Determination;Enrollment;Equity;experience;Funding;Goals;higher education;improved;innovation;Institution;Investments;K-Series Research Career Programs;Knowledge;life-long learning;matriculation;Medical;Mentors;model building;Outcome;outcome disparities;Population;Positioning Attribute;Program Evaluation;programs;Research;resilience;Science;skill acquisition;skills;Structure;Students;success;System;Thinking;Training;Training Activity;undergraduate research;undergraduate student;underrepresented minority student;Underrepresented Populations;United States;Universities

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE  Diffusion magnetic resonance imaging (dMRI) has a unique ability to non-invasively characterize microstructure and long range connectivity in brain tissues with coherent organization, such as white matter (WM), but has been less effective in more complex tissues that lack such coherency, such as gray matter (GM). This has limited its potential in detection and characterization of widespread but often subtle brain GM and WM changes associated with Alzheimer's disease and its related dementias (ADRD), Our proposal will optimize and validate a novel extension of dMRI that can simultaneously assess both GM and WM microstructure and connectivity in order to translate it into a new practical clinical imaging method for improved detection of Alzheimer's disease-related microstructural abnormalities.

PI_NAMEs: BONDI, MARK W;FRANK, LAWRENCE R (contact);HUTCHINSON, ELIZABETH B

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: abeta deposition;Activities of Daily Living;Aging;aging process;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Anisotropy;Architecture;Arizona;Autopsy;Brain;Brain imaging;brain tissue;Clinical;clinical imaging;Cognitive;cognitive ability;cohort;Complex;Computational Technique;Computer Simulation;Data;Dementia;Detection;Diffusion;diffusion anisotropy;Diffusion Magnetic Resonance Imaging;Dimensions;economic implication;Entropy;experimental study;Ferrets;Fiber;Geometry;Goals;gray matter;Heterogeneity;Histologic;Human;human subject;human tissue;Hybrids;Image;imaging modality;Imaging Techniques;Impaired cognition;improved;in vivo;in vivo evaluation;insight;Joints;Magnetic Resonance Imaging;Maps;Measures;Methodology;Methods;Microscopic;mild cognitive impairment;Morphologic artifacts;Motion;Multimodal Imaging;Nerve Degeneration;neural;neural tract;Neurofibrillary Tangles;new technology;normal aging;novel;Participant;Pathologic;Pathology;Patients;Performance;Physiologic pulse;Protocols documentation;Proxy;Radiology Specialty;Reporting;Research;Resolution;Scanning;Sensitivity and Specificity;Signal Transduction;simulation;simulation environment;social implication;Source;Specificity;Structural defect;Structure;Techniques;Testing;Time;Tissue Model;Tissues;tool;Translating;Translations;Universities;Validation;Water;white matter;white matter change;Work

PROJECT_TITLE: Joint Estimate Diffusion Imaging (JEDI) for improved Tissue Characterization and Neural Connectivity in Aging and Alzheimer's Disease

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Digestive Diseases;Inflammatory Bowel Disease;Microbiome;Nutrition;Prevention

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Novel imaging technologies are needed to facilitate the study and visualization of the early and low-grade gastrointestinal (GI) inflammation. Our proposal aims to establish fluorescence lifetime imaging (FLIm) as a nondestructive and label-free research tool to visualize and quantify the tissue-level response to microbiome- mediated inflammation using the in vivo murine colon as a study model. The long-term goal of this research seeks to translate FLIm as a clinical tool for the early diagnosis of human GI inflammatory diseases.

PI_NAMEs: ALFONSO-GARCIA, ALBA  (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Abscess;Adult;Agonist;Animal Model;Animals;Antibiotic Therapy;Antibiotics;Applications Grants;Autopsy;Biochemical;Biological Assay;Biopsy;Characteristics;Chronic;Clinical;cofactor;Colon;Colonic inflammation;Colonoscopy;Colorectal;Communicable Diseases;Contrast Media;Data;Diagnosis;Diameter;dietary;Disease;disease diagnosis;disease model;Disease Progression;dysbiosis;Dysplasia;Early Diagnosis;Endoscopy;Energy Metabolism;Environment;Epithelium;Exhibits;Female;Fiber;Fistula;Fluorescence;fluorescence lifetime imaging;Funding;gastrointestinal;Gastrointestinal Diseases;gastrointestinal imaging;Gastrointestinal tract structure;Glycolysis;Goals;gut dysbiosis;health care service utilization;High Fat Diet;Histopathology;host microbiota;Hour;Human;human imaging;Hypoxia;Image;image processing;imaging detection;Imaging Device;imaging modality;imaging probe;Imaging Techniques;Immune response;In Situ;in vivo;in vivo fluorescence;in vivo imaging;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;Intervention;intestinal epithelium;Intestines;Knockout Mice;Label;Laboratories;Lateral;Length;Link;Magnetic Resonance;male;Malignant Neoplasms;Mediating;Medical;Metabolic;Metabolism;meter;Methods;microbiome;microbiota;Modality;Modeling;Monitor;Motion;Mus;NADH;novel;novel imaging technology;Nutritional;operation;Operative Surgical Procedures;optical fiber;Optics;Outcome;oxidation;Oxygen;Pathogenesis;patient prognosis;Patients;Perforation;Personal Satisfaction;pharmacologic;physical conditioning;PPAR gamma;Process;Property;Quality of life;Recording of previous events;Research;Research Project Grants;Resolution;response;Side;Speed;Statistical Data Interpretation;Streptomycin;Structure;Study models;Symptoms;Technology;Testing;Thick;Time;Tissues;tool;Translating;treatment response;United States;Visual;Visualization;Wild Type Mouse;X-Ray Computed Tomography

PROJECT_TITLE: Fluorescence Lifetime Imaging (FLIm): a method to evaluate colon inflammation in vivo

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ORG_CITY: NEW HAVEN

ORG_DEPT: PHARMACOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative ALK receptor expression and mutation are oncogenic drivers in multiple cancers, particularly in pediatric neuroblastoma. The ALK receptors form a unique family of receptor tyrosine kinases whose mechanisms of regulation are poorly understood. This proposal aims to elucidate the molecular underpinnings that dictate and direct ALK receptor signal transduction to uncover novel therapeutic opportunities.

PI_NAMEs: KLEIN, DARYL EWALD (contact)

PROGRAM_OFFICER_NAME: KYI, CINDY WIN

PROJECT_TERMS: Address;Adopted;Affect;Amino Acids;anaplastic lymphoma kinase;Antibodies;Architecture;Binding;Biochemical;Biological Assay;Biological Products;biophysical properties;Biophysics;Caenorhabditis elegans;Cells;Cellular Assay;Cessation of life;Childhood;Clinical;Complex;Complex Analysis;Crystallography;Cysteine;design;Development;dimer;Disease;disorder risk;Drosophila genus;Embryonic Development;Epitope Mapping;Epitopes;extracellular;Family;Fibronectins;Foundations;Genetic;Genetic study;Glycine;Goals;high risk;Homologous Gene;Immunoglobulin Fragments;In Vitro;inhibitor;insight;Invertebrates;Knowledge;Length;Ligand Binding;Ligands;Link;Logic;LTK gene;Malignant Childhood Neoplasm;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Mediating;member;Membrane;Molecular;Monoclonal Antibodies;mutant;Mutation;neural;Neuroblastoma;neuron development;new therapeutic target;Normal tissue morphology;novel therapeutics;Oncogenic;Outcome;overexpression;Pathogenicity;Pathway interactions;Peptides;Peripheral Nervous System;Phage Display;Phosphotransferases;Play;polyglycine;pre-clinical;Proteins;rational design;receptor;Receptor Activation;receptor expression;receptor function;Receptor Protein-Tyrosine Kinases;Receptor Signaling;Regulation;Regulatory Element;Reporting;Research;response;Sensory;Signal Induction;Signal Pathway;Signal Transduction;Structure;System;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Intervention;tool;Translating;transmission process;tumor;Vertebrates;virtual

PROJECT_TITLE: Identifying opportunities for extracellular inhibition of ALK signaling

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

PHR: Project Narrative The proposed research is relevant to public health because it will identify the pathways and mechanisms by which ENPP1 induces low bone mass, as well as an investigation into a therapeutic treating paradoxical mineralization states, which fracture and survival rates demonstrate to be poorly understood and treated by current therapies. The deliverables of the proposal are not only important for understanding an unknown form of hereditary osteoporosis, they may also contribute to our understanding of an adynamic bone disease present in chronic renal failure known as chronic kidney disease bone mineralization disorder CKD-MBD, in which ENPP1 activity is also known to be reduced.

PI_NAMEs: BRADDOCK, DEMETRIOS  (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Adolescent;Adult;Aging;Animal Model;arterial calcification of infancy;Automobile Driving;autosome;bench to bedside;Biochemical;Biological;Biological Availability;Biological Markers;Biological Products;bone;Bone Diseases;bone fragility;Bone Growth;bone loss;bone mass;Bone Matrix;calcification;Calcitriol;candidate identification;Catalysis;Cells;Chronic Kidney Failure;Clinic;conventional therapy;Data;design;Development;Diet;Disease;early onset;Engineering;enzyme replacement therapy;Enzymes;Exhibits;Experimental Designs;experimental study;Familial hypophosphatemic bone disease;Fracture;fracture risk;Genetic;Genetic Transcription;Genetic Transduction;Goals;Growth;Human;in vivo;Inherited;inhibitor;inorganic phosphate;Investigation;Kidney;Ligaments;Mammals;Medical;mineralization;Minerals;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Mutation;novel;Organ;Osteoporosis;Pathway interactions;Patient Agents;Patients;Phenotype;Physiologic calcification;Physiologic Ossification;Plasma;plasma cell membrane glycoprotein PC-1;Population;posterior longitudinal ligament ossification;Primary Cell Cultures;Proteomics;Public Health;Publications;Recording of previous events;Regulation;Regulatory Pathway;Reporting;Research;response;Risk;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Signaling Protein;skeletal;skeletal disorder;Skeleton;soft tissue;success;Supplementation;Survival Rate;Tendon structure;Therapeutic;Therapeutic Agents;Tissues;Transgenic Mice;translational study;United States National Institutes of Health

PROJECT_TITLE: ENPP1 regulation of mammalian bone mass

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Aging;Clinical Research;Diabetes

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Numerous studies support the premise that inflammation rises in aging. Drugs with anti- inflammatory actions such as metformin may promote healthspan, the length of one's life spent in good health, especially if given prior to onset of age-related declines. We will analyze deidentified samples from an NIA-funded clinical trial to test the possibility that baseline insulin sensitivity impacts the ability of metformin to ameliorate pathogenic inflammation.

PI_NAMEs: NIKOLAJCZYK, BARBARA  (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Address;Age;Age of Onset;age related;Age related comorbidities;age related decline;aged;Aging;aging biomarker;aging related;Ancillary Study;Anti-Inflammatory Agents;arm;Autophagocytosis;Bioenergetics;Bioinformatics;Blood specimen;Body Composition;Cell Physiology;Cells;Chronic;clinical practice;Clinical Trials;Complex;Confusion;Coupled;cytokine;Data;Defect;Diabetes Mellitus;Disease;Double-Blind Method;Enhancers;Equilibrium;Exercise;FRAP1 gene;Funding;glycemic control;Goals;Health;healthspan;Human;Immune;improved;In Vitro;Inflammaging;Inflammation;Inflammatory;inflammatory marker;insight;Insulin;Insulin Resistance;insulin sensitivity;Interleukin-10;Interleukin-6;Intervention;Length;Life;life span;Link;Mediating;Metabolic;Metabolism;Metformin;Methods;Mitochondria;Muscle Fibers;Muscle function;Muscle Mitochondria;Myeloid Cells;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Organelles;Outcome;Overweight;Oxidation-Reduction;Pathogenicity;Pathway interactions;Persons;Pharmaceutical Preparations;Placebos;Positioning Attribute;predictive modeling;primary endpoint;Production;recruit;repaired;Reporting;response;Risk;Sampling;Serum;Skeletal Muscle;Source;success;systemic inflammatory response;T-Lymphocyte;Testing;Tissues;trait;Variant;Work

PROJECT_TITLE: The impact of insulin sensitivity on the potential of metformin to delay age-related inflammation

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Dietary Supplements;Nutrition

ORG_DEPT: ORTHOPEDICS

PHR: PROJECT NARRATIVE Macrophages are immune cells that propagate inflammation in many inflammatory and autoimmune diseases. Choline metabolism during macrophage activation is essential for lipid remodeling and cytokine production. Identifying the cellular responses that are fueled by choline during macrophage differentiation and activation are essential for defining innovative therapeutic manipulations critical to myriads of inflammatory diseases including rheumatic diseases such as osteoarthritis, gout, or rheumatoid arthritis.

PI_NAMEs: SANCHEZ-LOPEZ, ELSA  (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Advisory Committees;Affect;Animal Model;Anti-Inflammatory Agents;Arthritis;Autoimmune Diseases;autoinflammatory diseases;Bioenergetics;Biology;Blood;CD14 gene;Cd68;Cells;Cellular Membrane;Choline;Choline Kinase;choline transporter;Clinical;collaborative environment;coping;cytokine;Data;Degenerative polyarthritis;deprivation;Development;Disease;Disease Progression;Exhibits;experience;Familial amyloid nephropathy with urticaria and deafness;Funding;Genetic;Gout;Hallmark Cell;Heterogeneity;Human;IL18 gene;Immune;In Vitro;in vivo;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;innovation;Institution;interest;Interleukin-1 beta;Joints;Lecithin;lipidomics;Lipids;Macrophage;Macrophage Activation;Membrane;Mentors;Mentorship;Metabolic;Metabolic Pathway;Metabolism;metabolome;metabolomics;Mitochondria;Mitochondrial DNA;mitochondrial membrane;Mitochondrial Proton-Translocating ATPases;Molecular;monocyte;mouse model;Myelogenous;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;novel;novel therapeutic intervention;Nutrient;nutrient metabolism;Organizational Change;oxidation;Patients;Pattern;peripheral blood;pharmacologic;Phenotype;Phospholipids;Phosphorylation;Play;Population;Positioning Attribute;prevent;Prevention;Production;Productivity;Research;Research Personnel;Resolution;Resources;response;Rest;Rheumatism;Rheumatoid Arthritis;Role;Spain;Spirometry;Stimulus;Synovial Fluid;Synovial Membrane;Texas;Therapeutic;therapeutic target;Tissues;tool;Training;Translational Research;translational study;Universities;uptake;Vision;Vitamins;Work

PROJECT_TITLE: Role of choline metabolism in activated macrophage phenotypes

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Burden of Illness;Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Machine Learning and Artificial Intelligence;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE Given the extraordinary rise in the number of wildfires in the Western US over the past decade, we seek to use Medicare data and emergency department visit data to quantify the relationships between acute and chronic exposure to wildfire smoke and cardiovascular disease outcomes. Combining advanced chemical transport models and machine learning techniques, we will generate detailed estimates of major air pollutants in smoke, then establish concentration-response functions of multiple CVD endpoints, and then estimate future smoke- related CVD burden due to climate change. The findings of this study will fill major knowledge gaps and improve our understanding of the serious threat of increasing wildfire activities to population health.

PI_NAMEs: FU, JOSHUA S;LIU, YANG  (contact)

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: Acute;Acute myocardial infarction;Affect;Air;Air Pollutants;Air Pollution;ambient air pollution;Area;atmospheric chemistry;Atrial Fibrillation;burden of chronic illness;burden of illness;Calibration;Canada;Carbon;Cardiotoxicity;Cardiovascular Diagnostic Techniques;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cessation of life;Chemicals;Chronic;Climate;climate change;climate zone;Communities;cost;Crossover Design;Data;Data Set;design;Disease Outcome;Elements;Emergency department visit;Emergency response;Epidemiology;epidemiology study;Event;experience;Exposure to;fine particles;Fire - disasters;Formaldehyde;Future;Gases;Goals;greenhouse gases;Health;Healthcare;Heart failure;Hospitalization;improved;Industrialization;Knowledge;Link;Longitudinal cohort;Machine Learning;machine learning model;Measurement;Measures;Medicare;Modeling;models and simulation;Morbidity - disease rate;mortality;Nitrates;Ozone;Pathway interactions;Patients;pollutant;Population;Population Growth;population health;Public Health;Records;Research;Resolution;response;Risk;Seasons;sensor;Smoke;socioeconomics;Stroke;study population;Sulfate;supercomputer;Survival Analysis;Techniques;Tennessee;Time;Travel;Universities;US State;Vehicle Emissions;Wildfire

PROJECT_TITLE: The impact of wildfire smoke exposure on cardiovascular health in the western US

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: CLEMSON

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: PROJECT NARRATIVE The homologous recombination pathway plays critical roles during the response to replication stress and disruption of the response leads to a wide variety of human diseases. We are elucidating the molecular mechanisms of recombination proteins at stalled replication forks. Our discoveries will lead to a better understanding of how disruption of the pathway results in human disease potentially leading to identification of novel targets for therapeutics for recombination-deficient inherited disorders and cancer.

PI_NAMEs: MASON, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Alleles;Area;biological adaptation to stress;cancer predisposition;cellular targeting;Chromosomal Instability;Data;Defect;Development;Disease;Dissection;DNA biosynthesis;DNA replication fork;Double Strand Break Repair;Enzymes;experimental study;Face;Foundations;Future;Genes;Genetic;Genetic Recombination;genome integrity;Genome Stability;Genomic Instability;Goals;Hereditary Disease;homologous recombination;human disease;hydroxyurea;Inherited;insight;Malignant Neoplasms;Modeling;Molecular;Molecular Biology;new therapeutic target;novel;novel therapeutics;Pathway interactions;Patients;Play;Proteins;Proteomics;replication stress;response;Role;Series;Source;Stress;Syndrome;Testing;therapeutic development;Work

PROJECT_TITLE: Role of homologous recombination in the replication stress response

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-I(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Summary Lewy body diseases (LBDs), including Parkinson's disease (PD), Parkinson's disease dementia (PDD), and dementia with Lewy bodies (DLB), share a common spectrum of disease pathology but also have distinct Lewy Body deposition patterns which were correlated with regional-specific neuronal loss and the unique clinical manifestations in each disease. This proposal will dissect the molecular mechanisms of selective neuronal and regional vulnerability in LBDs via novel genomics technologies and bioinformatics tools. Our study will provide molecular biomarkers and tools for neuron cell-type-specific protection and targeted astrocyte/microglia subpopulation isolation and manipulation as well as molecular biomarkers for distinguishing PD, PDD, and DLB.

PI_NAMEs: XU, JINBIN ;ZHAO, GUOYAN  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Address;Affect;alpha synuclein;amyloid pathology;Animal Model;Astrocytes;Bioinformatics;bioinformatics tool;Brain;Brain Diseases;Brain Pathology;Brain region;Brain Stem;case control;Cell Nucleus;cell type;Cells;Clinical;Cognitive;Collaborations;comparative;Data;Dementia;Dementia with Lewy Bodies;Deposition;Disease;Disease associated microglia;Disease Progression;dopaminergic neuron;Female;frontal lobe;Functional disorder;Gene Expression Profile;Genetic Markers;genetic signature;Genomics;Human;Inflammation;Inflammatory;insight;Knowledge;Lewy Bodies;Lewy Body Dementia;Lewy Body Disease;Lewy neurites;Libraries;male;Microglia;Molecular;molecular marker;Monitor;motor symptom;Mus;Neocortex;Nerve Degeneration;Neurites;Neurodegenerative Disorders;Neuroglia;neuron loss;neuronal cell body;Neurons;new technology;novel;Onset of illness;Parkinson Disease;Parkinson's Dementia;Pathogenesis;Pathology;Pathway interactions;Patients;Pattern;Pilot Projects;protein aggregation;putamen;regional difference;response;Rest;Sampling;single nucleus RNA-sequencing;Substantia nigra structure;Suspensions;Symptoms;Technology;Testing;Time;tool

PROJECT_TITLE: Dissect the mechanisms of selective regional vulnerability in Lewy Body Dementias via comparative snRNA-seq analysis


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Pediatric

ORG_CITY: BOSTON

ORG_STATE: MA

PHR: NARRATIVE  Pediatric cardiology, like all of medicine, is poised to benefit from burgeoning advancements in genetics, genomics, bioengineering, and developmental, cellular and molecular biology. It is also fertile ground for rigorous prospective clinical investigation related to bioengineering, transcatheter, and pharmacological interventions, as well as cell therapy and regeneration for selected cardiovascular diseases. This Training Program will recruit basic, translational, and clinical researchers to these tasks and train them to bridge the still substantial gap between the laboratory and the bedside in pediatric cardiology.

PI_NAMEs: DE FERRANTI, SARAH D;NEWBURGER, JANE W.;PU, WILLIAM TSWENCHING (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TITLE: Research Methods in Pediatric Cardiovascular Disease

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


NIH_SPENDING_CATS: Arthritis;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dissemination and Implementation Research;Mental Health;Pain Research;Pediatric;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE There is a critical need to improve the long-term physical and psychosocial outcomes of adolescents with chronic musculoskeletal pain (CMP) in order to reduce healthcare utilization and mitigate the psychosocial sequelae of ongoing chronic pain in this vulnerable patient population. The goal of the proposed research is to examine the impact of a resilience coaching program adapted for adolescent chronic musculoskeletal pain in a pilot randomized controlled trial (RCT). Achievement of the study aims has the potential to be a significant contribution to building and fostering resilience among adolescents with chronic musculoskeletal pain, as the proposed research will inform a future multicenter RCT of the resilience coaching program and thereby augment current interdisciplinary management of adolescent CMP.

PI_NAMEs: GMUCA, SABRINA ANDREA (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: acceptability and feasibility;Achievement;Address;Adolescent;Adolescent and Young Adult;Adult;Affect;Age;aged;Anxiety;arm;behavioral health intervention;bone;burden of illness;career;career development;Caregivers;Caring;Child;Child health care;Child Psychology;Childhood;Chronic Childhood Arthritis;Chronic Disease;chronic musculoskeletal pain;chronic pain;chronic pain management;Clinical;Clinical Trials;Clinical Trials Design;Cognitive;Cognitive Therapy;cohort;Collaborations;comorbidity;Complement;Data;Development;Educational Intervention;Effectiveness;efficacy evaluation;enhanced care;experience;Face;Feedback;Fostering;functional disability;Future;future implementation;Goals;health care service utilization;implementation efforts;implementation evaluation;implementation intervention;implementation outcomes;implementation science;Improve Access;improved;innovation;insight;Institution;inter-individual variation;interdisciplinary approach;Intervention;Interview;Investigation;Joints;K-Series Research Career Programs;Knowledge;Learning;Lupus;Medical Care Costs;Mental Depression;Mentorship;Methods;mindfulness;Multicenter Trials;multidisciplinary;Muscle;novel;Occupational;Outcome;Pain;Pain intensity;pain outcome;Pain Research;Parents;Participant;patient population;Patients;Pediatric Hospitals;pediatric rheumatic diseases;Pennsylvania;Persistent pain;Phase;Philadelphia;pilot trial;Population;post intervention;preference;prevent;primary outcome;Process;programs;promote resilience;Provider;psychologic;psychological distress;psychosocial;Psychosocial Factor;psychosocial outcome;Randomized, Controlled Trials;Recommendation;remote delivery;Research;Research Methodology;Research Personnel;resilience;Resources;rheumatologist;Rheumatology;Role;routine care;Scientist;secondary outcome;Severities;sex;skills;Societies;soft tissue;stress management;Structure;Surveys;Symptoms;Teenagers;tertiary care;theories;Training;treatment as usual;Treatment outcome;Treatment Protocols;treatment responders;treatment response;Universities;Work;Youth

PROJECT_TITLE: A Pilot Randomized Controlled Trial of Resilience Coaching for Adolescents with Chronic Musculoskeletal Pain


NIH_SPENDING_CATS: Drug Abuse (NIDA only);Substance Misuse

ORG_DEPT: PSYCHIATRY

PHR: The past five years have been transformative in our understanding of the neurobiology of the addictive and therapeutic potential of drugs of abuse. Given the highly polygenic and multi-factorial nature of drug use and misuse, and the growing emphasis on incorporating neuroscience into precision medicine, there is an immediate need for young investigators with training in biomedical approaches. Led by scientists who are deeply invested in human (Dr. Agrawal) and animal (Dr. Moron-Concepcion) addiction neurobiology, the competing continuation of this training grant will continue to provide research training in genetics, neuroscience, neuroimaging, neuropharmacology, statistics/computation and biology as well as career development to 6 postdoctoral scholars with MDs or PhDs. Situated within the Department of Psychiatry at Washington University School of Medicine, and supported by 27 preceptors, this T32 will leverage the extensive array of coursework, workshops and seminars available across the medical and arts and sciences campuses and rich assortment of large datasets available to trainees.

PI_NAMEs: AGRAWAL, ARPANA  (contact);MORON-CONCEPCION, JOSE A

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Biomedical Research;Drug abuse;Research Training

PROJECT_TITLE: Biomedical Research Training in Drug Abuse


ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: This R01 application will investigate a targeted nanoparticle that possesses the ability to selectively knockdown multiple proteins in drug resistant lung cancer cells and thereby sensitize tumors to therapy. The project goal is to assess safety and efficacy of the nanoparticle-platform in murine and canine models to ease clinical translation for patients with drug resistant non-small cell lung cancer.

PI_NAMEs: KANNAN, RAGHURAMAN  (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: acquired drug resistance;analytical method;Animal Cancer Model;Animal Model;Antibodies;Automobile Driving;axl receptor tyrosine kinase;Binding;Biodistribution;Biological Assay;Bypass;Cancer Etiology;Cancer Model;Cancer Patient;cancer therapy;canine model;Canis familiaris;Cell Death;Cells;checkpoint therapy;Chemoresistance;Clinical;clinical efficacy;clinical translation;Clinical Trials;clinically relevant;combat;Combined Modality Therapy;Data;Disease remission;Dose;Down-Regulation;Drug Kinetics;Drug resistance;Drug Targeting;efficacy evaluation;Epidermal Growth Factor Receptor;Exhibits;Future;Gelatin;Goals;Guidelines;Hepatic;Human;Immune;Immune checkpoint inhibitor;immune resistance;Immune response;Immunocompetent;immunoregulation;Immunotherapy;improved;In Vitro;in vivo;in vivo Model;inhibitor;inhibitor therapy;Kidney;knock-down;large scale production;Lead;Libraries;lung cancer cell;Malignant neoplasm of lung;manufacture;men;Metastatic Neoplasm to the Lung;Mind;Molecular;mortality;mouse model;Mus;mutant;Mutate;Mutation;Nanoconjugate;nanoparticle;nanoparticle drug;NF-kappa B;Non-Small-Cell Lung Carcinoma;novel;novel strategies;novel therapeutics;Oncogenes;Outcome;overexpression;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Production;protein expression;Proteins;Protocols documentation;Publishing;Quality Control;Radiology Specialty;Resistance;response;RNA Degradation;Safety;safety assessment;Sarcoma;Signal Pathway;Signal Transduction;Small Interfering RNA;stem;survival outcome;Survival Rate;synergism;System;Therapeutic;Therapeutic Agents;therapeutic target;therapeutically effective;therapy outcome;Toxic effect;Toxicology;Translations;Treatment Efficacy;tumor;tumor growth;tumor microenvironment;Tyrosine Kinase Inhibitor;Woman;Xenograft procedure

PROJECT_TITLE: Towards Translation of MU-CN29: New Therapeutic Nanoparticle for Drug-Resistant NSCLC


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Malaria;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT SUMMARY/ABSTRACT Malaria cases and deaths primarily caused by Plasmodium falciparum have declined significantly in sub- Saharan Africa as a result of the broad deployment of vector control and effective clinical management. In low to moderate-transmission settings slated for elimination, imported cases become an increasingly important epidemiological consideration. In these settings, imported cases may a) represent a high but poorly defined proportion of the overall malaria burden, b) result in secondary transmission that can impede local elimination efforts, and c) may require additional or alternative interventions than standard control measures. Imported cases, when currently evaluated at all, are operationally defined as infections acquired outside of a defined geographic area and identified based on travel history. However, lack of capture of asymptomatic infections together with variable quality of travel history collection limit the utility of this standard approach to identifying imported infections and quantifying their role in transmission. Further, there are no routinely collected data that would allow evaluation of the impact of imported cases on local transmission. In this proposal, we will collect detailed travel histories, perform active surveillance for asymptomatic infections, and generate parasite genomic data to more accurately define the role of imported infections in two representative border regions of sub-Saharan Africa (Tororo District, Uganda and Mutasa District, Zimbabwe) that leverage substantial surveillance infrastructure from the NIH-funded International Centers of Excellence for Malaria Research (ICEMR) network and will employ active (via a longitudinal study) and passive (via health facility surveillance) designs to capture asymptomatic and symptomatic infections. We propose the following Specific Aims.1) To quantify and characterize imported malaria infections. We will use a probabilistic approach to classify infections as imported or local via detailed travel and other behavioral survey data and determine the travel patterns and risk factors associated with importation. 2) To determine the impact of importation on local transmission and identify appropriate targeted interventions. We will use parasite genomics and epidemiological data to define local transmission and the impact of imported infections, taking advantage of dense sampling of symptomatic and asymptomatic infections in focused geographies. We will use a robust set of statistical modeling approaches, including Bayesian estimation of transmission networks incorporating all genomic and epidemiologic data. We will use these data to model the predicted impact of various combinations of targeted interventions. The expected outcome of the proposed research is evidence on appropriate surveillance methods for imported malaria infections and on the contribution of these infections to sustaining transmission. By identifying ways to better target interventions, these results will impact malaria control efforts as they strive for elimination and require evidence on how to mitigate the risk of imported malaria infections.

PI_NAMEs: RODRÍGUEZ-BARRAQUER, ISABEL  (contact);WESOLOWSKI, AMY

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Adult;Africa South of the Sahara;Alternative Therapies;analytical method;Area;Behavioral;Cessation of life;Classification;Clinical Management;Collection;Data;design;Diagnosis;epidemiologic data;Epidemiology;Failure;Funding;genomic data;Genomics;Geographic Locations;Geography;Health care facility;Household;Impact evaluation;improved;Individual;Infection;Infrastructure;International;international center;Interruption;Intervention;Longitudinal Studies;Malaria;malaria infection;malaria transmission;Measures;Mozambique;Outcome;Parasites;Pattern;Plasmodium falciparum;predictive modeling;Recording of previous events;Reporting;Research;Residual state;Resources;Risk Factors;risk mitigation;Role;Sampling;Site;Statistical Models;Surveillance Methods;Surveys;Testing;transmission process;Travel;Uganda;United States National Institutes of Health;vector control;Zimbabwe

PROJECT_TITLE: Malaria across borders:  Measuring imported infections and contributions to local transmission in Uganda and Zimbabwe

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Contraception/Reproduction;Infertility;Neurosciences;Nutrition;Women's Health Research

PHR: PROJECT NARRATIVE Many metabolic disorders are associated with infertility and sex hormone dysregulation, though the molecular mechanisms that link nutrient status to reproductive events are not well understood. The evolutionarily conserved Integrated Stress Response (ISR) pathway responds to environmental and cellular stress cues like starvation, directing transcriptional changes that prioritize survival at the temporary expense of nonessential processes like oogenesis and mating. The work proposed herein will combine genetic, biochemical, and neuromodulatory tech- niques to examine how the ISR links nutrient status to reproductive potential via steroid hormones, revealing new insights into how metabolism impacts fertility across organisms.

PI_NAMEs: GRMAI, LYDIA  (contact)

PROGRAM_OFFICER_NAME: GIBBS, KENNETH D

PROJECT_TERMS: Address;Adipose tissue;Anorexia Nervosa;Attenuated;Award;Behavior;Behavioral;Biochemical;biological adaptation to stress;Body fat;Brain;brain control;Cells;Cellular Stress;Cessation of life;Collaborations;cost;Courtship;Cues;Data;Defect;Deposition;detection of nutrient;Disease;Drosophila genus;Drosophila melanogaster;Ecdysone;ecdysone receptor;Ecdysterone;egg;Egg Yolk Proteins;Endowment;Energy Metabolism;Event;Fat Body;feeding;Female;Fertility;fitness;forging;Foundations;Gametogenesis;Genetic;Genetic Transcription;Germ Cells;Gonadal Steroid Hormones;Gonadal structure;Graafian Follicles;Homeostasis;Hormonal;hormonal signals;Hormones;Human;Infertility;insight;intestinal homeostasis;Intestines;Laser Scanning Confocal Microscopy;Link;Lipids;Liver;Mentors;Metabolic;Metabolic Diseases;Metabolism;Methods;model organism;Molecular;Nervous System control;neural;neuronal circuitry;Neurons;Neuropeptides;neuroregulation;Neurosciences;novel;novel therapeutics;Nutrient;Nutrient availability;nutrient deprivation;nutrition;Nutritional;Nutritional status;offspring;oocyte maturation;Oocytes;Oogenesis;Organ;Organism;Ovary;Ovulation;Partner in relationship;Pathway interactions;Peripheral;Phase;Physiological;Physiology;Polycystic Ovary Syndrome;Process;Production;programs;Protein Biosynthesis;Proteins;receptor;Regulation;Reporter;Reproduction;reproductive;Reproductive Behavior;Research;Research Personnel;Resource Allocation;response;Role;Sense Organs;sensor;Signal Pathway;Signal Transduction;Site;Starvation;stem cells;steroid hormone;steroid hormone receptor;Stress;Stress Response Signaling;Synapses;System;Techniques;Testing;Tissues;tool;Training;transcription factor;Universities;Whole Organism;Work

PROJECT_TITLE: Stress response signaling as a metabolic sensor in reproduction


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Social Determinants of Health

PHR: Project Narrative The University of Arizona Center on Aging (ACOA) proposes to implement the ACOA/MSTEM THRIVE Program, a focused (improving health, wellbeing and independence of older adults in diverse groups), structured, longitudinal, mentored research education program targeting undergraduates from groups underrepresented in the health sciences (URHS) enrolled at the University of Arizona (UA). These students will be principally of Latino and American Indian/Native American descent, or from U.S-México border region. The project is designed to cultivate, support, advance and sustain undergraduate student progress toward careers in biomedical, behavioral and clinical research.

PI_NAMEs: FAIN, MINDY J;PHILLIPS, LINDA R (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Address;Aging;Alaska Native;American Indians;Arizona;Behavioral;Behavioral Research;Biological Factors;Biomedical Research;biopsychosocial;career;Clinical Research;Country;cultural competence;design;Discipline of Nursing;Economics;Education;education research;Enrollment;ethnic diversity;experience;Geography;Geriatrics;Gerontology;Goals;graduate school;Health;Health Disparities Research;health disparity;Health Sciences;Health Status;Hispanic;improved;innovation;interest;Knowledge;Latino;literacy;matriculation;Medicine;Mentors;Mexico;Native American population;Native Americans;older adult;Older Population;Output;Personal Satisfaction;Pharmacy facility;Population;Population Heterogeneity;Positioning Attribute;programs;Public Health;Qualifying;rapid growth;recruit;Research;Research Personnel;Resources;response;rural area;Scientist;skills;social;Strategic Planning;Structure;student participation;Students;success;summer research;Talents;Teacher Professional Development;Training and Education;Training Programs;undergraduate education;undergraduate student;Underrepresented Populations;United States;United States National Institutes of Health;Universities

PROJECT_TITLE: ACOA/MSTEM THRIVE Program for Undergraduates


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: GRAND FORKS

ORG_NAME: UNIVERSITY OF NORTH DAKOTA

ORG_STATE: ND

PHR: Overall Project Narrative American Indians (AIs) experience disproportionately high rates of trauma-related health disparities. This COBRE aims to mentor junior faculty at UND to enhance research capacities and skills and to address AI health disparities related to trauma, and the health promoting effects of resilience. Three individual research projects include: (1) Historical trauma and resilience as a biological state and its association with the effects of the traditional Indigenous food chokeberry; (2) Impact of boarding school attendance on perceived stress, allostatic load and resilience; and (3) Stress and health in American Indian pregnancies.

PI_NAMEs: GEIGER, JONATHAN DAVID (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: academic program;addiction;Address;Advisory Committees;Age;allostatic load;American Indian community;American Indians;Award;Basic Science;Behavioral;Biological;career;Centers of Research Excellence;Cessation of life;Chippewa;Chronic Disease;Collection;Communities;community based participatory approach;community based participatory research;community engagement;Community Outreach;Core Grant;Development;Disparity;Education;emotional trauma;Enrollment;Ensure;Epigenetic Process;experience;Faculty;Food;Funding;Funding Opportunities;Future;Goals;graduate student;Grant;Health;health disparity;health inequalities;Health Promotion;human subject;Human Subject Research;improved;Indigenous;indigenous community;Individual;Infant Mortality;infrastructure development;Institution;Interdisciplinary Study;interest;intergenerational;Link;member;Mentors;Methods;Native-Born;North Dakota;Outcome;Peer Review;perceived stress;Personal Satisfaction;Pine Ridge Indian Reservation;poor health outcome;Post-Traumatic Stress Disorders;Poverty;Pregnancy;Principal Investigator;programs;protective factors;psychological trauma;Publishing;R24;Research;Research Assistant;Research Infrastructure;Research Personnel;Research Project Grants;resilience;resilience research;Risk Factors;Sampling;Scholarship;Schools;Senior Scientist;Services;skills;Social Conditions;Stress;success;Suicide;Teton Sioux Indian;Training;Training Activity;Translational Research;Trauma;Trauma Research;tribal community;Tribes;Turtles;Unemployment;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Indigenous Trauma & Resilience Research Center


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Injury - Accidents and Adverse Effects;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: WARNE, DONALD KEITH (contact)

PROJECT_TERMS: adverse childhood events;Advisory Committees;American Indians;Awareness;career;career development;Centers of Research Excellence;Communities;community engagement;Community Outreach;Dedications;Development;Development Plans;Discipline;Ensure;Epigenetic Process;Evaluation;Event;experience;Faculty;Funding;Future;Goals;Health;health disparity;human subject;Indigenous;Individual;Infrastructure;knowledge base;Leadership;Link;meetings;member;Mentors;Mentorship;Methods;multidisciplinary;North Dakota;Pilot Projects;Principal Investigator;Process;programs;Progress Reports;Public Speaking;Publications;recruit;Research;Research Personnel;Research Project Grants;Research Training;resilience research;Senior Scientist;Series;skills;Students;success;symposium;Teacher Professional Development;timeline;Training;Trauma;Trauma Research;Universities;Work;Writing

PROJECT_TITLE: Indigenous Trauma & Resilience Research Center- Administrative Core


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Prevention;Psychosis;Serious Mental Illness;Suicide;Suicide Prevention

ORG_CITY: LA JOLLA

PHR: PROJECT NARRATIVE Opportunity and motivation to seek help are vital to long-term suicide prevention and to outreach in times of acute suicide-related crises, and yet almost half of people do not disclose suicidal thoughts to anyone. This study combines lab-based and digital data collection tools to investigate how specific deficits in the reward system interfere with long-term supportive relationships and to social outreach behavior during crisis, in order to identify new treatment targets for improving the interpersonal aspects of an array of suicide prevention strategies.

PI_NAMEs: DEPP, COLIN A. (contact);TAYLOR, CHARLES

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Accounting;Acute;Affect;Affective;affective psychoses;approach behavior;avoidance behavior;Basic Science;Behavior;Buffers;Chronic;Code;Computing Methodologies;Data;Data Collection;data integration;Data Set;data streams;design;Diagnosis;Diagnostic;digital data;digital mental health;Disclosure;dynamic system;Ecological momentary assessment;Elements;Emotions;experience;Face;Feeling suicidal;help-seeking behavior;ideation;Impairment;improved;Individual;innovation;interest;Intervention;Learning;Link;longitudinal design;Longitudinal Studies;Measurement;Measures;Mediating;mHealth;Modeling;Mood Disorders;Motivation;motivational processes;National Institute of Mental Health;Natural Language Processing;Negative Valence;novel;outreach;Participant;Patient Recruitments;Persons;Play;Populations at Risk;Positive Valence;predictive modeling;Prevention;Prevention strategy;preventive intervention;Process;Psychopathology;psychotic;Psychotic Disorders;recruit;Research;Research Domain Criteria;Resources;response;Rewards;Role;Safety;Sampling;smartphone based assessment;social;Social Behavior;Social Network;Social outcome;Social Processes;social relationships;Specific qualifier value;speech processing;Strategic Planning;suicidal behavior;suicidal risk;Suicide;suicide attempter;Suicide prevention;suicide rate;Syndrome;System;Testing;Time;tool;Translating;Withdrawal;Work

PROJECT_TITLE: Transdiagnostic Reward System Dynamics and Social Disconnection in Suicide

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Digestive Diseases

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: NARRATIVE This proposal will investigate how epithelial cells that line mucosal surfaces, and macrophages that are a key innate immune cell involved in host defense against infection, communicate with each other to cross-regulate each other’s function in homeostasis and following microbial challenge. We will investigate how modification of an essential protein tyrosine phosphatase in one cell type changes the behavior of the other cell using novel model systems with complementary in vivo and in vitro approaches. In addition, we will identify novel mediators and mechanisms of cellular cross-talk that are vital for macrophage polarization, epithelial barrier maintenance and protection against infection at mucosal surfaces.

PI_NAMEs: MCCOLE, DECLAN  (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Activities of Daily Living;Address;Adoptive Transfer;Affect;Anti-Inflammatory Agents;antimicrobial;behavior change;Biological Models;Biology;Cell Communication;cell growth regulation;Cell Line;Cell Physiology;cell type;Cells;chronic autoimmune disease;Citrobacter rodentium;Coculture Techniques;Communication;Complex;cytokine;Data;DNA Sequence Alteration;Elements;enteric pathogen;Epithelial Cells;Epithelium;Event;experimental study;Exposure to;Gastrointestinal tract structure;Goals;gut inflammation;Homeostasis;Host Defense;Human;human model;Immune;Immune response;Immunity;Immunobiology;improved;In Vitro;in vivo;Infection;Inflammation;innate immune function;innate immune mechanisms;innovation;intestinal barrier;intestinal epithelium;intestinal homeostasis;Intestinal permeability;Intestines;Knock-out;Knockout Mice;Link;Macrophage;Maintenance;Mediating;Mediator;microbial;Modification;Molecular;monocyte;mouse model;Mucous Membrane;Mus;Myelogenous;Nature;novel;Peptide Signal Sequences;Permeability;Phosphoric Monoester Hydrolases;Play;preservation;Property;Protein Tyrosine Phosphatase;Regulation;Research Personnel;response;Role;Series;Signal Pathway;Signal Transduction;Surface;synergism;System;T-cell protein tyrosine phosphatase;Testing;Tight Junctions;Transgenic Mice;Work

PROJECT_TITLE: Tyrosine Phosphatase Regulation of Mucosal Macrophage-Epithelial Cell Cross-talk

STUDY_SECTION: GMPB

STUDY_SECTION_NAME: Gastrointestinal Mucosal Pathobiology Study Section[GMPB]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Methamphetamine;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: CHICAGO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: Narrative: A significant population of HIV infected people abuse drugs such as Methamphetamine (Meth). Both Meth and HIV can affect the brain negatively. HIV also hides in the brain even if it is not detected in the blood. Studying where HIV hides in the brain and effects of HIV and Meth on the brain is difficult because the brain cannot be accessed unless the person is deceased and even then, there are limits to what one can learn from these brains. As a result, there are animal models that are half human/half mouse brain that can be used to understand where HIV hides in the brain of Meth users. We will u se these models in a unique way by taking cells from Meth using/ HIV positive people and reprogramming them to become brain cells to put into these mice to understand the extent of where HIV hides, effects on the brain, and how HIV genotype changes over time (evolution). Together, these studies will allow us to define the scope of the challenge to be in a better place to solve it.

PI_NAMEs: AL-HARTHI, LENA  (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: abuse victim;Acquired Immunodeficiency Syndrome;Address;Affect;AIDS population;Animal Model;Animals;antiretroviral therapy;Area;astrocyte progenitor;Astrocytes;Autopsy;Biological Assay;Biology;Blood;Blood - brain barrier anatomy;blood-brain barrier disruption;Brain;brain cell;brain tissue;CD34 gene;cell repository;Cells;Chimera organism;cohort;Collaborations;comorbidity;DNA Repository;Drug abuse;drug of abuse;Engraftment;Evolution;experience;Functional disorder;Gene Expression Profile;genetic signature;Genetic study;Genetic Transcription;genome sequencing;Genotype;Glues;HIV;HIV envelope protein;HIV Infections;HIV Seronegativity;HIV Seropositivity;HIV-associated neurocognitive disorder;HIV/AIDS;Homeostasis;Human;human model;humanized mouse;Immunofluorescence Immunologic;immunoregulation;Impaired cognition;In Situ;In Vitro;in vitro activity;in vivo;Individual;Induced Neurons;induced pluripotent stem cell;Infection;Inflammatory;Inflammatory Response;innovation;Invaded;Kinetics;Knockout Mice;Knowledge;Learning;Link;long term abstinence;Lymphocyte;lymphocyte trafficking;Mediating;Mediator;METH abuser;Methamphetamine;methamphetamine effect;methamphetamine use;methamphetamine user;Modeling;Molecular;mouse model;Mus;National Institute of Drug Abuse;National Institute of Neurological Disorders and Stroke;neglect;nerve stem cell;Neurocognitive Deficit;Neurodegenerative Disorders;Neuroglia;Neuronal Injury;Neuropathogenesis;Neurotransmitters;neurotrophic factor;neurotropic;news;next generation;novel;Organ;Peripheral;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Phenotype;Population;programs;psychostimulant;repaired;Research;Resources;Risk Factors;Role;stem cell model;Techniques;Testing;Time;Tissues;tool;United States National Institutes of Health;Viral

PROJECT_TITLE: Human/Animal Brain Chimera in drugs of abuse and HIV

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Injury - Accidents and Adverse Effects;Racial and Ethnic Minority Health Research;Rural Health

PI_NAMEs: NADEAU, MELANIE  (contact)

PROJECT_TERMS: Address;American Indian community;American Indian Population;American Indians;Back;Basic Science;Centers of Research Excellence;Communication;Communities;community advisory board;community based participatory research;community based research;community engaged research;community engagement;Community Outreach;Data Analyses;Development;Doctor of Philosophy;Education and Outreach;emotional trauma;Equipment and supply inventories;experience;Focus Groups;Goals;Growth;Health;health disparity;Health Priorities;Health Resources;Health Status;Human Resources;improved;Indigenous;Individual;informant;Institutional Review Boards;Interview;Letters;Link;Medicine;meetings;Mentors;Methods;multidisciplinary;North Dakota;Outcome;outreach;Persons;Pilot Projects;Policy Developments;Process;Program Development;programs;protective effect;Protocols documentation;Public Health;Reduce health disparities;Reporting;Research;Research Activity;Research Personnel;Research Priority;Research Project Grants;Research Training;resilience;resilience research;Senior Scientist;success;Time;Training;Training and Education;Translating;Trauma;Trauma Research;tribal community;tribal health;tribal leader;tribal medicine;tribal member;Tribes;Universities;Washington;Work

PROJECT_TITLE: Community Engagement O Core


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: The discovery of GPIHBP1 as the transporter of lipoprotein lipase (LPL) transformed textbook descriptions of intravascular triglyceride processing, but the model remains incomplete. Our objectives are to investigate the function of GPIHBP1's intrinsically disordered acidic domain and to refine our understanding of GPIHBP1 and LPL localization and function within the capillary lumen. An improved understanding of plasma triglyceride physiology is quite relevant to human metabolic diseases, including atherosclerotic coronary heart disease.

PI_NAMEs: BEIGNEUX, ANNE ;FONG, LOREN GI (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Address;Amino Acid Sequence;Autoantibodies;Binding;Biochemical;Blood capillaries;Capillary Endothelial Cell;Cell membrane;Complex;Confocal Microscopy;Coronary heart disease;Cysteine;Disease;Electron Microscopy;Electrostatics;Endothelial Cells;experimental study;Fingers;Functional disorder;Funding;Genes;Glycocalyx;Grant;Heparan Sulfate Proteoglycan;Human;human disease;Hydrolase;Hypertriglyceridemia;Image;imaging modality;improved;in vivo;insight;interest;Investigation;Journals;Knock-in Mouse;Link;Lipolysis;Lipoprotein Binding;lipoprotein lipase;Lipoproteins;Manuscripts;Metabolic Diseases;Metabolism;Microscopy;Missense Mutation;Modeling;monomer;Movement;Mus;Mutagenesis;mutant;Mutant Strains Mice;Mutation;National Heart, Lung, and Blood Institute;novel;Paper;Physiological;Physiology;Plasma;Positioning Attribute;preservation;prevent;Principal Investigator;Productivity;Proteins;Publishing;Reagent;Risk Factors;rituximab;Role;Site;Structure;Surface;Surface Plasmon Resonance;Techniques;Testing;Textbooks;tool;trafficking;TRAP Complex;Triglyceride Metabolism;Triglycerides;ultra high resolution;Work

PROJECT_TITLE: Refining Physiologic Mechanisms for Intravascular Triglyceride Metabolism

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]