ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative (Overall) The proposed studies will use a broad range of approaches to understand how intracellular pathogens mediate their pathogenesis and how the host immune system prevents disease. These studies will lead to the characterization of host systems of innate immunity that will lead to vaccines and/or therapeutics to prevent and/or treat infectious diseases, with relevance to domestic and global health.

PI_NAMEs: PORTNOY, DANIEL A (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: adaptive immune response;adaptive immunity;Address;Adjuvant;Affect;anakinra;Antibacterial Response;Antibodies;antiviral immunity;Autophagocytosis;Bacteria;Bacterial DNA;Bacterial Infections;biosafety level 3 facility;Brain;burden of illness;Cells;Classification;Collaborations;collaborative approach;Communicable Diseases;Communities;Complex;Cytosol;Data;Dedications;Defense Mechanisms;design;detection platform;Dinucleoside Phosphates;Disease;DNA;ELF3 gene;Engineering;Enzymes;extracellular;follow-up;Foundations;Future;global health;Goals;Immune;Immune response;Immune system;Immunity;Immunobiology;immunogenicity;improved;Infection;innate immune pathways;Innate Immune Response;Innate Immune System;innovation;insight;Interferon Type I;Interferons;Interleukin-1;International;Intranasal Administration;Invaded;Investigation;Knowledge;Legionella pneumophila;Listeria monocytogenes;Mediating;meetings;Membrane;Microbiology;Modeling;mutant;Mycobacterium tuberculosis;Natural Immunity;novel therapeutic intervention;novel vaccines;Oral;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Peptide Initiation Factors;Perforation;Periodicity;Phagosomes;Placenta;Play;Positioning Attribute;prevent;Production;Program Research Project Grants;programs;Proteins;receptor;Research;Research Support;Resources;response;Role;success;synergism;System;T-Lymphocyte;targeted treatment;Therapeutic;Translating;Tuberculosis;Tuberculosis Vaccines;Ubiquitin;vaccination outcome;vaccine development;vaccine strategy;Vaccines;vector;Virulence;Virulence Factors;Virulent;Virus Diseases

PROJECT_TITLE: The intersection of innate and adaptive immunity to intracellular pathogens


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_STATE: CA

PHR: Project Narrative (Core A, Portnoy) The proposed studies will lead to the characterization of host systems of innate immunity that will lead to vaccines and/or therapeutics to prevent and/or treat infectious diseases, with relevance to domestic and global health. Core A will provide administrative support and promote synergy among all projects and cores.

PROJECT_TERMS: adaptive immunity;Area;biodefense;Biology;California;Cell Nucleus;Collaborations;collaborative approach;Communicable Diseases;Coronavirus;Dedications;Elements;Emerging infection;Ensure;Evaluation;global health;Hour;Human Resources;Immunology;Interview;Joints;Leadership;meetings;microbial;Microbiology;Molecular Genetics;nanosystems;Natural Immunity;Occupational activity of managing finances;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Postdoctoral Fellow;posttranscriptional;prevent;Productivity;professor;Program Evaluation;programs;Research;Research Personnel;response;Series;Services;Subgroup;success;synergism;System;Teleconferences;Therapeutic;vaccine development;Vaccines;vaccinology

PROJECT_TITLE: Administrative Core A


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_CITY: SEATTLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: We anticipate that the successful completion of our aims will advance clinical practice guidelines for cervical cancer prevention for WLWH in diverse geographic settings, influence public health policy, and ultimately reduce healthcare disparities.

PI_NAMEs: BROWN, ELIZABETH RENATA;WINER, RACHEL L. (contact)

PROGRAM_OFFICER_NAME: FRECH, MARIA SILVINA

PROJECT_TERMS: Ablation;Address;Aftercare;antiretroviral therapy;attributable mortality;base;Cancer Control;Cancer Prevention Intervention;career;cervical cancer prevention;Cervical Cancer Screening;Clinical;Clinical effectiveness;clinical implementation;Clinical Practice Guideline;Clinical Research;clinical research site;clinical training;Clinical Trials;Collaborations;Communication;cost;Decision Making;Detection;Development;Discipline;E-learning;Education;Effectiveness;effectiveness outcome;Electronics;Epidemiology;ethnic disparity;follow-up;Fostering;fundamental research;Geography;global health;Goals;Gynecologic Oncology;health care disparity;Health Policy;HIV;HIV-1;HIV/AIDS;HPV positive;HPV screening;Human Papillomavirus;implementation outcomes;implementation research;implementation science;improved;Incidence;Infrastructure;innovation;Interdisciplinary Study;Intervention;Lateral;Lead;Leadership;loop electrosurgical excision procedure;low and middle-income countries;Malignant neoplasm of cervix uteri;Manuscripts;Mentorship;Methodology;Methylation;Modality;Molecular;Morbidity - disease rate;Multi-Institutional Clinical Trial;Nurses;online course;operation;Outcome;pragmatic randomized trial;pragmatic trial;premalignant;Preparation;preventive intervention;Procedures;programs;Protocols documentation;Public Health;quality assurance;racial disparity;Recurrence;Research;Research Personnel;Resource-limited setting;Risk;Sampling;scale up;Scholars Program;Science;scientific hub;screening;screening services;Site;skills;socioeconomic disparity;Stains;standard of care;Statistical Data Interpretation;statistics;Structure;Thermal Ablation Therapy;Training;treatment as usual;treatment services;Triage;trial design;Universities;virtual;Washington;Woman;Women's Health;Women's mortality;women's prevention;women's treatment;Writing

PROJECT_TITLE: The CASCADE CLIMB: Cervical cancer prevention in women Living with HIV research Mobilization Base


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

PHR: Project Narrative (Core B, Stanley) The objective of the BSL3 Core is to provide comprehensive, state-of-the-art research support to all four projects of this P01 in the manipulation and study of M. tuberculosis, a notoriously difficult pathogen to study. This Core serves to lower the substantial barriers inherent in working with this pathogen, to provide access to state-of-the-art technologies, and to ensure standardization across projects.

PI_NAMEs: STANLEY, SARAH A (contact)

PROJECT_TERMS: adaptive immunity;animal care;Animals;Antibiotic Resistance;Autophagocytosis;Biological Assay;biosafety level 3 facility;Cell Separation;Cells;Chromium;confocal imaging;Containment;Core Facility;cost efficient;Dedications;Devices;Ensure;Environmental Health;Equipment;experimental study;fluorescence activated cell sorter device;Generations;Genomics;Goals;Human;human morbidity;human mortality;Human Resources;Image;imaging system;Immune;Immune response;in vivo;Infection;Infection prevention;Infrastructure;innovation;insight;Institution;instrumentation;investigator training;Investments;Laboratories;Legionella pneumophila;Libraries;Listeria monocytogenes;Maintenance;microscopic imaging;Molecular;mortality;Mus;Mycobacterium tuberculosis;Natural Immunity;new technology;novel therapeutic intervention;novel therapeutics;novel vaccines;operation;pandemic disease;pathogen;pathogenic bacteria;Postdoctoral Fellow;Principal Investigator;Procedures;programs;Protocols documentation;Reagent;repaired;Research;Research Personnel;Research Support;resistant strain;Safety;single-cell RNA sequencing;Standardization;success;Technical Expertise;Technology;Testing;tool;Training;Tuberculosis;Tuberculosis Vaccines;Vaccination;vaccine development;vaccine trial;Veterinarians;Work

PROJECT_TITLE: Core B: BSL3 Advanced Technologies and Animal Infection Core


ADMINISTERING_IC: HD

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Disability Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Rehabilitation

ORG_CITY: HOUSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: Project narrative: We propose a fully-faceted summer research training program at the University of Houston IUCRC BRAIN Center to provide specialized training in innovative neuro tools, computational, and neuroengineering techniques to complement and enhance the training of therapists, clinical and research fellows, and orthotists and prosthetists from a diverse neurorehabilitation and neuroengineering community.

PI_NAMEs: CONTRERAS-VIDAL, JOSE LUIS (contact);PARIKH, PRANAV J

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Academy;Address;Adjusted Life Years;Adult;Advertisements;Aging;Alzheimer's Disease;Artificial Intelligence;Awareness;Behavioral Research;Biomedical Engineering;Biomedical Research;Brain;Brain Diseases;BRAIN initiative;brain research;Budgets;career;Child;Child Welfare;Childhood;Chronic Disease;Clinical;Clinical Research;clinically relevant;Cognition;Collaborations;Communities;Complement;computerized tools;Development;Device or Instrument Development;Diagnosis;disability;Disease;Doctor of Philosophy;Educational workshop;Elements;Emerging Technologies;Emotions;Engineering;Ethics;Ethnic Population;experience;Faculty;faculty mentor;Future;General Population;Goals;graduate student;Grant;Health;health management;Health Sciences;Healthcare;Human;human subject;improved;Individual;innovation;innovative neurotechnologies;Institution;Intention;interest;Investigation;Knowledge;Laboratory Research;Literature;Machine Learning;Medical;Medical center;meetings;Mentors;multidisciplinary;Nervous System Disorder;neural;neural patterning;neuroethics;neuroimaging;neurological rehabilitation;neuroregulation;Neurosciences;neurotechnology;new technology;next generation;Parkinson Disease;Participant;Perception;physically handicapped;Population;Postbaccalaureate;Prevention;programs;racial population;Recommendation;recruit;Reporting;Research;Research Methodology;Research Personnel;Research Project Grants;Research Training;Reverse engineering;Science;Scientist;skills;Societies;Spinal cord injury;Stroke;success;summer research;Supervision;Technical Expertise;Techniques;Technology;Texas;tool;Training;Training Programs;Underrepresented Populations;United States National Institutes of Health;Universities;virtual reality;Woman;Work

PROJECT_TITLE: Neuromotor Skill Advancement for Post baccalaureates

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD-K]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative Alternative splicing (AS) is critical for expanding the complexity of genetic information encoded in the mammalian genome. Mutations affecting AS regulation provide an important source of genetic innovations during evolution, but are also implicated in an expanding list of genetic diseases ranging from neurological disorders to cancer. Discoveries from this study can be highly relevant to understand human traits and susceptibility to genetic diseases.

PI_NAMEs: ZHANG, CHAOLIN  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;Affect;Alternative Splicing;Biological Models;Code;Computing Methodologies;Disease;driving force;Event;Evolution;Experimental Models;experimental study;Genes;Genetic;Genetic Diseases;genetic information;Genetic Variation;Health;Human;innovation;insight;Learning;Malignant Neoplasms;mammalian genome;Mammals;Maps;Molecular;multidisciplinary;Mutation;Nature;Nervous System Disorder;new technology;Pan Genus;Pattern;Phenotype;Population;Predisposition;Process;programs;Protein Isoforms;Quantitative Trait Loci;Regulation;Regulatory Element;Research;RNA Splicing;RNA-Binding Proteins;Source;technology development;trait;Transcript;Work

PROJECT_TITLE: Complexity and evolution of splicing-regulatory networks

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Immunization;Infectious Diseases;Prevention;Rare Diseases;Tuberculosis;Vaccine Related;Women's Health Research

PHR: Project Narrative (Project 1, Portnoy) The proposed studies will use a broad range of approaches to understand how intracellular pathogens mediate their pathogenesis and how the host immune system prevents disease. These studies will lead to the characterization of host systems of innate immunity that will lead to vaccines and/or therapeutics to prevent and/or treat infectious diseases, with relevance to domestic and global health.

PROJECT_TERMS: adaptive immunity;Address;Alleles;Anabolism;Antigen Presentation;Bacillus subtilis;Bacteria;Bacterial Infections;bacterial metabolism;Binding;Biological Models;Brain;Cells;Cellular biology;Collaborations;Communicable Diseases;Communities;Data;Dinucleoside Phosphates;Disease;Drug Efflux;efflux pump;Electron Transport;Enterocolitis;extracellular;Flavins;foodborne pathogen;Funding;Genes;global health;Goals;Human;Immune response;Immune system;Immunity;Infection;innate immune pathways;Innate Immune Response;Innate Immune System;interest;Interferon Type I;Interferons;International;isoprenoid;Learning;Legionella pneumophila;Listeria;Listeria monocytogenes;Listeriosis;Longitudinal Studies;Mediating;Metabolism;mevalonate;Microbiology;microorganism;Modeling;Mucous Membrane;Mus;mutant;Mycobacterium tuberculosis;Natural Immunity;novel;Nutritional Requirements;Oral;oral infection;pathogen;Pathogenesis;Pathway interactions;Patient observation;Periodicity;Placenta;placental infection;Play;prevent;Prevention;Primates;Regulation;response;Riboflavin;Role;Shapes;Signal Transduction;Signaling Molecule;System;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;tissue culture;Tuberculosis;tuberculosis immunity;Tuberculosis Vaccines;vaccine development;Vaccines;γδ T cells

PROJECT_TITLE: Project 1: Listeria metabolites and innate immunity


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Diabetes;Genetics;Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Both obesity and consequent diabetes are highly prevalent worldwide, and given their profound impact on morbidity and mortality, limiting these conditions is a major health challenge of our time. This proposal seeks to address critical knowledge gaps in our mechanistic understanding of the molecular and cellular factors driving a process termed fat “fibrosis”, which we showed is associated with insulin resistance in humans, and the extent to which these factors reciprocally govern an alternative process, termed “beiging”, which is associated with metabolic health and insulin sensitivity. The knowledge we gain from this mechanistic inquiry, which will be undertaken using an innovative human fat tissue repository as well as strategically designed mouse models, may be broadly applied to determine clinically relevant links between obesity and diabetes.

PI_NAMEs: ALBA, DIANA LUCIA (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Activities of Daily Living;Address;Adipocytes;Adipose tissue;Automobile Driving;Basic Science;bioinformatics tool;Biology;blood glucose regulation;Body fat;Body mass index;Body Weight;career;career development;CD81 gene;Cell Count;Cell surface;cell type;Clinical;clinically relevant;cofactor;cohort;comorbidity;Complement;Computational Biology;Coupled;Data;Dedications;design;Deterioration;Diabetes Mellitus;diabetes pathogenesis;diabetes risk;Disease;East Asian;Energy Metabolism;Ensure;Environment;Equilibrium;Ethnic Origin;Ethnic Population;Faculty;falls;Fatty acid glycerol esters;Fibrosis;Frequencies;Functional disorder;Funding;Gender;Gene Expression Profile;Genes;Genetic;Genetic Models;Genetic Transcription;Genetic Variation;genome wide association study;Glucose;Goals;Growth;GTF2IRD1 gene;Health;high risk population;Hormones;Human;human old age (65+);Hyperplasia;Hypertrophy;Impairment;Inbred Mouse;Inbred Strains Mice;Individual;Inflammation;innovation;insulin regulation;Insulin Resistance;insulin sensitivity;interest;Intra-abdominal;K-Series Research Career Programs;Knowledge;Learning;Link;lipid biosynthesis;Mediator;member;Mentors;Metabolic;metabolic phenotype;Modeling;Molecular;Molecular Biology;Molecular Probes;Morbidity - disease rate;mortality;mouse model;multi-ethnic;multiple omics;Mus;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Obesity;Participant;Pathway interactions;Pattern;personalized approach;Persons;Phenotype;Physicians;Population;Process;Production;Race;racial diversity;racial population;Recombinants;Research;Research Personnel;Resources;Risk Marker;Role;Scientist;Series;skills;stem cell differentiation;stem cells;subcutaneous;System;Thermogenesis;Time;Tissue Banks;Tissue Expansion;tool;Training;Transcriptional Regulation;transcriptome;Transforming Growth Factor beta;Translational Research;Translations;Visceral;Visceral fat;Vulnerable Populations;Work

PROJECT_TITLE: Dissecting the cellular interplays of adipose tissue remodeling in the regulation of insulin sensitivity

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK(M1)-1-B]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Liver Cancer;Liver Disease;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE  Black patients with chronic liver disease are approximately 50% less likely than White patients to receive curative therapies for hepatocellular carcinoma (HCC) even when presenting with early-stage disease. Reasons for disparities in mortality are multifactorial but may be related to failure to progress through the complex HCC care continuum to access curative therapies as a result of the unequal distribution of social and structural determinants of health. The HCC-EduLink intervention we propose to develop is designed to: a) improve patients’ HCC-related disease and treatment knowledge; b) screen patients for social needs and substance use and refer to social work for linkage to local services; and c) use our multidisciplinary HCC tumor board to facilitate linkage to subspecialty HCC cancer care, improving access to curative therapies for Black patients with chronic liver disease and HCC.

PI_NAMEs: NEPHEW, LAUREN  (contact)

PROGRAM_OFFICER_NAME: JOSEPH, SUSAN KALAPURA

PROJECT_TERMS: access disparities;Active Learning;Address;Alcohols;behavior test;Behavior Therapy;behavioral health;Behavioral trial;black patient;Black race;cancer care;Cancer Center;cancer health disparity;Cancer Prognosis;career;Caring;Characteristics;chronic liver disease;Clinic;Clinical Sciences;cohort;Complement;Complex;Consent;Continuity of Patient Care;curative treatments;Data;Death Rate;design;Disease;disparity reduction;Education;Educational Status;Enrollment;Environment;Epidemiology;Equitable healthcare;Evidence based intervention;Excision;experience;Failure;Funding;Gastroenterologist;Goals;Grant;Health;health difference;health disparity;Health Services Accessibility;Health Services Research;Health system;high school;Hospitals;human centered design;implementation intervention;implementation science;Improve Access;improved;Indiana;Individual;Inequity;information gathering;Intervention;intervention effect;Knowledge;Liver diseases;liver transplantation;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of liver;medically underserved population;Mentors;Mentorship;Methods;mortality;mortality disparity;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Outcome;Participant;patient screening;Patients;pilot test;Poverty;Primary carcinoma of the liver cells;programs;Prospective, cohort study;Provider;racial disparity;Randomized;randomized trial;Randomized, Controlled Trials;Reduce health disparities;Reporting;Research;Research Methodology;Research Personnel;safety net;Services;skill acquisition;skills;social;Social Conditions;social determinants;Social Work;standard of care;structural health determinants;substance use;Surveys;System;Testing;therapy design;therapy development;Time;Training;Training Programs;Translational Research;tumor;Universities;usability;Vulnerable Populations;Waiting Lists;Work

PROJECT_TITLE: Overcoming Racial Disparities in Curative Therapies for Hepatocellular Carcinoma


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Complementary and Integrative Health;Depression;Lung;Mental Health;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: In humans, continuous breathing from birth is essential to life and requires that the nervous system generate a reliable and robust rhythm that drives inspiratory and expiratory muscles. The proposed studies will significantly advance our understanding of how controlled breathing can produce positive effects on emotional state for amelioration of anxiety, fear, and panic.

PI_NAMEs: FELDMAN, JACK L (contact)

PROGRAM_OFFICER_NAME: CHEN, WEN G

PROJECT_TERMS: Ablation;Affect;Anxiety;Behavior;Behavioral;Birth;Blood gas;Brain;Brain Stem;Breathing;Carbon Dioxide;central pattern generator;Clinic;Clinical;Data;Databases;design;detection platform;emotion regulation;Emotional;Emotional disorder;Emotions;experimental study;Exposure to;Fright;Future;Genetic;Goals;Hippocampus;Human;human disease;improved;Learning;Life;locus ceruleus structure;Lung;Maps;Measures;Mediating;Meditation;Mental Depression;Methods;Modeling;Moods;Mus;Muscle;negative emotional state;Nervous System;neural circuit;Neural Pathways;Neuroanatomy;neuromechanism;Neurons;neuroregulation;pain reduction;Panic;Paper;parabrachial nucleus;Pathway interactions;Pattern;Physiological;Placebo Effect;pranayama;preBotzinger complex;Reaction;Research;respiratory;response;Rodent;Rodent Model;Role;sensory system;Signal Transduction;Site;Smell Perception;Stress;stress related disorder;Structure;Synapses;Techniques;Testing;therapy development;transmission process;Vagus nerve structure;Visceral;Yoga

PROJECT_TITLE: RESPIRATORY CONTROL AND EMOTION REGULATION


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Our long-term goal is to engineer vascular composite allografts using patient specific cells for repairing composite tissue defects. The goal of this project is to construct an engineered fasciocutenous flap and validate their utility in a large animal model, which will allow rapid move into clinical translational studies.

PI_NAMEs: UYGUN, BASAK ELIF (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: 3-Dimensional;Accounting;Allografting;Anatomy;Animal Model;Architecture;Autologous;Binding;Biomaterials Research;Blood;Blood capillaries;blood perfusion;Blood Vessels;Cell Density;Cell fusion;cell growth;cell type;Cell-Matrix Junction;Cells;Chemicals;Clinic;Clinical;clinical translation;Clinical Trials;clinically relevant;Complex;Congenital Abnormality;Cues;Data;Defect;Deformity;Dermal;design;Development;disability-adjusted life years;dosage;Elastin;Endothelial Cells;Endothelium;Engineering;Environment;ex vivo perfusion;Extracellular Matrix;Extravasation;Face;Feedback;Fibroblasts;Fibronectins;global health;Goals;Growth;Growth Factor;Histologic;Histology;Immune;immunogenicity;Immunosuppression;in vivo;Inflammation;keratinocyte;Legal patent;Liquid substance;Malignant Neoplasms;Medical;Methods;Modeling;Molecular;Morbidity - disease rate;novel;Patients;Peptides;Physiological;Population;Proliferating;protein aminoacid sequence;Protocols documentation;public health relevance;Reconstructive Surgical Procedures;recruit;repaired;Research;restoration;Safety;scaffold;Scanning;Shapes;Site;Skin;soft tissue;Structure;synergism;System;Techniques;Testing;thrombogenesis;Tissue Engineering;Tissues;translational study;Transplantation;Trauma;Trees;vascular tissue engineering;Vascularization;Whole Blood;Work;X-Ray Computed Tomography

PROJECT_TITLE: Development of engineered fasciocutaneous skin flaps

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Rare Diseases;Tuberculosis;Vaccine Related

PHR: Project Narrative (Project 2, Cox) We have shown that M. tuberculosis initiates both anti-bacterial autophagy responses and pro-bacterial type I interferon responses of host macrophages, an effect that likely requires phagosome perforation mediated by the bacterium. We seek to understand the mechanism by which M. tuberculosis damages host membranes yet minimizes delivery of the bacterium to the autophagy pathway. In this proposal, we seek to use this information to test the effects of increased autophagy and interferon on eliciting protective immunity in order to create an effective vaccine.

PI_NAMEs: COX, JEFFERY S (contact)

PROJECT_TERMS: adaptive immunity;Adjuvant;Adult;Affect;Anti-Bacterial Agents;Antibiotic Resistance;Attenuated;Autophagocytosis;Bacillus;Bacteria;bacterial genetics;BCG Live;Biological Assay;Cell Membrane Permeability;Cell surface;Cells;Collaborations;Complex;Data;ELF3 gene;Endosomes;Engineering;Equilibrium;Gene Mutation;Genetic;genetic approach;Goals;Growth;Host Defense Mechanism;human morbidity;human mortality;Immune response;Immunity;Individual;Infection;innate immune pathways;Innate Immune Response;Interferon Type I;Interferons;Knowledge;Lead;Learning;Listeria monocytogenes;Lung infections;Lysine;Lysosomes;Macrophage;Mediating;Membrane;Modeling;Mus;mutant;Mycobacterium tuberculosis;Natural Immunity;novel;novel strategies;novel vaccines;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Perforation;Permeability;Phagosomes;Positioning Attribute;prevent;Process;Production;Protein Secretion;Proteins;Reagent;Recombinants;recruit;repaired;resistant strain;response;Rest;Role;Route;Safety;Signal Transduction;Signal Transduction Pathway;Sorting;Specific qualifier value;Surface;synergism;System;Testing;Time;Titrations;Toxin;Tuberculosis;Tuberculosis Vaccines;Ubiquitin;ubiquitin ligase;Vaccination;vaccine development;Vaccines;Viral;Virulence;Work

PROJECT_TITLE: Project 2: Innate immune responses triggered by M. tuberculosis phagosomal perforation


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Microbiome

ORG_CITY: BLACKSBURG

ORG_DEPT: BIOLOGY

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative / Public Health Relevance The microbial community in the human gut is linked to numerous aspects of health and disease. Bacteriophages, the viruses of bacteria, are as abundant as bacteria in the gut with compositional correlations to disease, but it remains difficult to experimentally study the direct effect of phages in the gut microbiome. The work in this proposal will develop models to improve the study of phages in relevant models of the gut microbiome and characterize the mechanisms by which phage impact bacteria.

PI_NAMEs: HSU, BRYAN BOEN (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Antibiotics;Area;Bacteria;Bacteriophages;colonization resistance;dietary;Disease;Escherichia coli;experimental study;Goals;gut bacteria;gut microbiome;gut microbiota;Health;Human;Immune system;improved;insight;Laboratories;Link;Metabolic;metabolome;Methodology;microbial;microbial community;Modeling;Mus;Prophages;public health relevance;Research;Role;Virulent;Virus;Work

PROJECT_TITLE: Investigating the role of phage in the gut microbiome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-X(55)R]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Alzheimer's disease (AD) is sever neurodegenerative disease affecting aging Americans and exacts tremendous and increasing demands on patients, caregivers, and healthcare resources. This application will develop new deep learning (DL) based approaches for deriving AD-relevant endophenotypes from neuroimaging data, and associating these endophenotypes to genetic data. We expect to discover new genes relevant to AD which may leads to understanding of molecular basis of AD and potential new treatment.

PI_NAMEs: FORNAGE, MYRIAM ;JI, SHUIWANG ;ZHI, DEGUI  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: 3-Dimensional;Affect;Aging;aging brain;Algorithms;Alzheimer's Disease;Alzheimer’s disease biomarker;American;Area;Back;biobank;Bioinformatics;bioinformatics tool;Biology;biomedical imaging;Brain imaging;Caregivers;Clinical;cognitive function;cohort;Collaborations;Communities;Computer software;connectome;Data;data analysis pipeline;data imputation;data resource;data standards;deep learning;Dementia;disorder risk;Elderly;endophenotype;Functional disorder;Genes;Genetic;genetic architecture;Genetic study;genome wide association study;genome-wide;genomic epidemiology;genomic locus;graph neural network;Healthcare;Heart;Heritability;high dimensionality;human old age (65+);Image;imaging informatics;imaging modality;Impaired cognition;interest;Investigation;Label;loss of function;Machine Learning;Maps;Memory;Mendelian randomization;Methods;Modeling;Molecular;Molecular Epidemiology;multidisciplinary;multimodal neuroimaging;Neurodegenerative Disorders;neuroimaging;novel;Participant;Patients;Pattern;Phenotype;Prevention strategy;Public Health;Research;Research Personnel;Resources;Sampling;Source Code;Structure;Testing;therapeutic development;Time;Training;trait;vector;Visualization;whole genome

PROJECT_TITLE: Genetics of deep-learning-derived neuroimaging endophenotypes for Alzheimer's Disease


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

PHR: Project Narrative (Project 3, Vance) Intracellular bacterial pathogens cause significant mortality and morbidity worldwide. Here we propose to determine how innate immunity mediates resistance or susceptibility to three intracellular bacterial pathogens (Listeria monocytogenes, Legionella pneumophila, and Mycobacterium tuberculosis) with a particular focus on the role of type I interferons. We expect our work to lay a foundation for the rational therapeutic intervention in these infections.

PI_NAMEs: VANCE, RUSSELL E (contact)

PROJECT_TERMS: adaptive immunity;Address;Affect;anakinra;antagonist;Anti-Bacterial Agents;Anti-viral Response;Antibacterial Response;antiviral immunity;Bacteria;Bacterial Infections;Cells;Chromatin;Collaborations;Complex;CRISPR screen;cytokine;Data;Dinucleoside Phosphates;Foundations;Genes;Genetic;Genetic Transcription;Goals;Human;human morbidity;human mortality;IFNAR1 gene;Immunity;Infection;Innate Immune Response;Interferon Type I;Interferon-beta;Interferons;Interleukin-1;Interleukin-1 Receptors;Laboratories;Legionella pneumophila;Listeria monocytogenes;Mediating;Modeling;Morbidity - disease rate;mortality;Mus;Mycobacterium tuberculosis;Natural Immunity;neutrophil;new therapeutic target;novel;Nuclear;Nuclear Structure;pathogen;pathogenic bacteria;Pathway interactions;Periodicity;Play;Predisposition;prevent;Regulation;Regulatory Pathway;Reporter;Repression;Resistance;response;restraint;Role;Signal Transduction;Testing;Therapeutic antibodies;Therapeutic Intervention;Tuberculosis;Up-Regulation;Vaccine Therapy;Virus;Virus Diseases;Work

PROJECT_TITLE: Project 3: Negative regulation of type I interferons during bacterial infection


ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: Overall Narrative: We will continue to study the contribution of a subset of anti-DNA antibodies to cognitive impairment in neuropsychiatric lupus (NPSLE) in a mouse model and in patients, with a view to developing therapeutic strategies (Projects 1 and 2). We will study the impact of in utero exposure to these antibodies on brain development in a mouse model (Project 3).

PI_NAMEs: DIAMOND, BETTY  (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Acute;Adult;Affect;Angiotensin-Converting Enzyme Inhibitors;Anisotropy;Anti-DNA Antibodies;Anti-Hypertensive Agents;Anti-Inflammatory Agents;Antibodies;Antigens;Antinuclear Antibodies;Autoantibodies;Autoimmune Diseases;Autopsy;Behavior assessment;Behavioral;Blood - brain barrier anatomy;blood-brain barrier permeabilization;Body System;Brain;brain dysfunction;brain tissue;Cause of Death;Central Nervous System;Cerebrospinal Fluid;Classification;Clinical;Clinical Trials;Clinical Trials Design;Coagulation Process;Cognitive deficits;cognitive function;cognitive testing;Complement 1q;Confusion;contrast enhanced;Cross Reactions;Data;Defect;Dendrites;design;Development;Diagnosis;Diagnostic;diagnostic value;Diffuse;Disease;DNA;drug development;efficacy evaluation;Electrophysiology (science);Ensure;excitotoxicity;Exposure to;Fc Receptor;Female;fetal;Fetal health;Fetus;Fiber;Functional impairment;Funding;glial activation;Hemorrhage;Hippocampus;Histologic;Impaired cognition;Impairment;improved;Inflammatory;Investigation;Kidney Diseases;Longitudinal Studies;Lupus;Magnetic Resonance Imaging;male;Mediating;meetings;Memory impairment;Meta-Analysis;Metabolic;Microglia;Modeling;Monoclonal Antibodies;Mothers;mouse model;Mus;N-Methyl-D-Aspartate Receptors;neuron loss;neuronal survival;Neurons;Neuropsychiatric Systemic Lupus Erythematosus;offspring;Organ;Pathogenicity;Pathway interactions;Patients;Penetration;Pharmaceutical Preparations;Placenta;Positioning Attribute;prenatal exposure;prevent;Prevention trial;Process;Production;programs;Property;Psychoses;Quality Control;Reagent;Rest;restoration;Serum;Skin Abnormalities;Skin Manifestations;spatial memory;Structural defect;Syndrome;Systemic Lupus Erythematosus;Testing;Therapeutic;Therapeutic Agents;way finding;white matter;Women's mortality;Work

PROJECT_TITLE: Anti NMDA Receptor antibodes in adult brain dysfunction and fetal brain development: lessons from lupus


NIH_SPENDING_CATS: Autoimmune Disease;Lupus;Neurosciences

PHR: PROJECT NARRATIVE – Administrative Core This Core will help with the coordination of all aspects of the research except the experimental work.

PROJECT_TERMS: Address;Adherence;Administrator;Adult;Anti-DNA Antibodies;Biometry;Brain;brain dysfunction;Budgets;cohesion;Cross Reactions;Development;Diamond;Exposure to;Fc Receptor;fetal;Funding;Goals;improved;Lupus;Manuscripts;meetings;mouse model;N-Methyl-D-Aspartate Receptors;Neurodevelopmental Impairment;Pathogenicity;Patients;prenatal exposure;Preparation;programs;Progress Reports;Reporting;Research;Research Personnel;Research Project Grants;Schedule;Science;Scientist;Services;Visit;Work

PROJECT_TITLE: Core A - Administrative Core


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Clinical Research;Immunization;Lupus;Neurosciences

PHR: PROJECT NARRATIVE – Monoclonal Antibody and Reagent Core This Core will provide monoclonal antibodies and assessments of antibody titer for the studies in the Program Project and for laboratories world-wide that are interested in initiating basic or clinical studies of neuropsychiatric lupus. The Core will also produce decoy antigens once a lead candidate is identified. The studies enabled by these antibodies will hasten clinical strategies for neuroprotection in patients with lupus.

PI_NAMEs: KOWAL, CZESLAWA HELENA (contact)

PROJECT_TERMS: Address;Adult;Affinity;Antibodies;Antibody Specificity;Antibody titer measurement;antigen binding;antigen test;Antigens;Area;Basic Science;Binding;Biological Assay;Brain;brain dysfunction;Chronic;Clinical;Clinical Research;cost effective;cross reactivity;Development;Diagnostic;DNA;Enzyme-Linked Immunosorbent Assay;Exposure to;Extracellular Domain;Fc Receptor;fetal;Fetus;G-substrate;Generations;Hippocampus;Human;Human Resources;IgG1;Immunoglobulin G;Impaired cognition;Impairment;In Vitro;Inflammatory;Injury;interest;Label;Laboratories;lead candidate;Lupus;Measures;Mediating;Medical Research;Microglia;Modality;Monoclonal Antibodies;mouse model;murine antibody;Mus;N-Methyl-D-Aspartate Receptors;neuroimaging;neuroprotection;Neuropsychiatric Systemic Lupus Erythematosus;Neuropsychology;novel therapeutics;offspring;Pathogenicity;Patients;Peptides;Phenotype;prenatal exposure;Preparation;preservation;Production;programs;prototype;Quality Control;Reagent;Recombinants;Research;Research Personnel;Resources;Secondary to;Serum;Services;Systemic Lupus Erythematosus;Testing;tool;Training;United States

PROJECT_TITLE: Core B- Monoclonal  Antibody and Reagent Core


NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Lupus;Neurosciences

PHR: PROJECT NARRATIVE – Behavior and Electrophysiology Core This Core will perform the assessments of behavioral and cognitive function and hippocampal electrophysiology of mice for Projects 1 and 3.

PI_NAMEs: HUERTA, PATRICIO T (contact)

PROJECT_TERMS: Adult;Affect;Animals;Anti-DNA Antibodies;Behavior;Behavior assessment;behavior test;Behavioral;behavioral outcome;behavioral study;Brain;brain dysfunction;Cognition;cognitive ability;cognitive function;cognitive task;Computer software;Computers;Core Facility;Cross Reactions;Data;Data Analyses;Data Collection;data standards;Data Storage and Retrieval;design;Development;Electrodes;Electrophysiology (science);Emotional;Ensure;Environment;Equipment;experience;experimental study;Exposure to;Fc Receptor;fetal;Guidelines;Hippocampus;human error;Human Resources;Impaired cognition;Implant;in vivo;Information Dissemination;large datasets;Lead;Learning;Lupus;Lupus Erythematosus;Manuals;Measurement;Measures;member;Memory;Methods;Mouse Strains;Mus;N-Methyl-D-Aspartate Receptors;Nervous System Physiology;Neurodevelopmental Impairment;Neurologic;Neurons;Neuropsychiatric Systemic Lupus Erythematosus;offspring;Physiology;Preparation;Procedures;Process;programs;Protocols documentation;Publications;Reflex action;Reporting;Reproducibility of Results;Research;Research Personnel;Resources;Rest;Running;Services;skills;Slice;Software Tools;Standardization;Syndrome;System;Technical Expertise;Techniques;Testing;Training

PROJECT_TITLE: Core C - Behavior and Electrophysiology Core


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: TUCSON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Lens transparency requires precise maintenance of ion and water content (homeostasis), something that is difficult to achieve because of the unique properties of lens cells. The proposed studies will lead us to understand TRP channel-dependent remote control mechanisms that adjust Na,K-ATPase and NKCC1 activity in lens epithelium in order to make homeostasis possible. The significance to human well-being is that lens optical clarity and refractive index depend on its water content and cataract is frequently associated with failed homeostasis.

PI_NAMEs: DELAMERE, NICHOLAS A (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Actins;arm;ATP1A1 gene;autocrine;Cataract;Cell membrane;Cell surface;Cells;Circulation;Compensation;Connexin 43;Connexins;Cytoskeleton;EGF gene;Epidermal Growth Factor Receptor;Epithelial Cells;Epithelium;Feedback;Fiber;fiber cell;Homeostasis;Human;Hydrostatic Pressure;Integrins;Ion Transport;Ions;lens;lens transparency;Link;Maintenance;MAPK3 gene;mechanical stimulus;Microtubules;Modeling;Monitor;monolayer;Optics;Pathway interactions;Personal Satisfaction;Pilot Projects;preservation;Property;receptor;Recovery;Refractive Indices;Regulation;remote control;Research;response;Rho-associated kinase;Role;Scheme;Signal Pathway;Signal Transduction;src-Family Kinases;Stretching;Surface;Swelling;symporter;Testing;TRP channel;TRPV1 gene;Tubulin;Update;Vision;Water

PROJECT_TITLE: TRP Channels as Master Controllers of Lens Function

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


PHR: Project 1 Narrative: We will study the mechanism of neuronal dysfunction and microglial activation in an antibody-mediated model of neuropsychiatric lupus, identify therapeutic approaches, and determine their mechanism of action.

PI_NAMEs: VOLPE, BRUCE THOMAS (contact)

PROJECT_TERMS: Acute;Adult;Albumins;Angiotensin Receptor;Angiotensin-Converting Enzyme Inhibitors;Animals;Antibodies;Antigen-Antibody Complex;Apoptotic;Autoantibody binding;Autoimmune;Binding;Blood - brain barrier anatomy;Brain;brain dysfunction;Brain Injuries;Brain Pathology;brain tissue;Cells;Central Nervous System;central nervous system injury;Cerebrospinal Fluid;Chronic;Circulation;Clinical;Clinical Trials;cognitive function;Complement 1q;Cross Reactions;cytokine;Dendrites;Development;Disease;DNA;druggable target;ds-DNA;Enzyme Inhibition;excitotoxicity;Exhibits;Exposure to;Fc Receptor;fetal;Functional disorder;Genetic Transcription;glial activation;Hippocampus;HMGB1 gene;human disease;Immune;Immunize;Impaired cognition;Impairment;In Vitro;in vivo;Ingestion;Injury;insight;Interferon Type I;Ligand Binding;Lipopolysaccharides;longitudinal analysis;Lupus;Mediating;Meta-Analysis;Methodology;Microglia;Modeling;Molecular;mouse model;Mus;N-Methyl-D-Aspartate Receptors;nerve injury;Nervous System Physiology;neuroimaging;neuron loss;Neuronal Dysfunction;neuronal survival;Neurons;neuropsychiatric symptom;Neuropsychiatric Systemic Lupus Erythematosus;Oligoclonal IgG;Pathology;Pathway interactions;Patients;pediatric patients;Penetration;Peptidyl-Dipeptidase A;Pharmaceutical Preparations;Porosity;Positron-Emission Tomography;prevent;programs;Property;Receptor Activation;reconstitution;release factor;risk variant;Serum;single nucleus RNA-sequencing;Site;Slice;spatial memory;Stress;Study models;Synapses;Systemic Lupus Erythematosus;targeted agent;Testing;Therapeutic;therapeutic target;Time;TLR4 gene

PROJECT_TITLE: Project 1 - Microglial activation in DNRAb-mediated brain pathology in mice


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

PHR: Project Narrative (Project 4, Stanley) The proposed research will advance our understanding of mechanisms underlying the efficacy of a novel cyclic-di-nucleotide adjuvanted protein subunit vaccine for tuberculosis. In addition, this project will seek to identify a heterologous prime-boost vaccination strategy that induces complementary forms of protective immunity. Thus the proposed research will help contribute fundamental knowledge that will inform translational applications with the goal of reducing the enormous burden that tuberculosis imposes on public health.

PROJECT_TERMS: adaptive immunity;Adjuvant;Adoptive Transfer;Antigen Presentation;Attenuated;Attenuated Vaccines;Autophagocytosis;Bacterial Infections;Biology;Cause of Death;CD8-Positive T-Lymphocytes;cell type;Cells;Collaborations;combat;Combined Vaccines;Data;design;Development;Dinucleoside Phosphates;Dissociation;Engineering;experimental study;Formulation;Goals;Growth;Human;IL17 gene;Immune;Immune response;Immunity;Immunization;Immunologic Memory;improved;Infection;Inflammation;Innate Immune Response;insight;Interferons;Interleukin-1;IRF3 gene;Knockout Mice;Knowledge;Laboratories;Listeria monocytogenes;Lung;mouse model;Mouse Strains;Mucous Membrane;Mus;Mycobacterium tuberculosis;Natural Immunity;novel;Output;pandemic disease;pathogen;Pathway interactions;Perforation;Periodicity;Phenotype;Play;Population;Primary Infection;Production;protective efficacy;Protein Subunits;Public Health;rBCG;Recombinants;recruit;Regimen;Reporting;Research;response;Role;Route;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Subunit Vaccines;T-Lymphocyte;Testing;translational applications;Tuberculosis;tuberculosis immunity;Tuberculosis Vaccines;Vaccinated;Vaccination;vaccination strategy;vaccine delivery;vaccine efficacy;vaccine evaluation;Vaccines;Work

PROJECT_TITLE: Project 4: The intersection of innate and adaptive immunity to M. tuberculosis


NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Lupus;Neurosciences

PHR: Project: Narrative This is a study designed to understand the impact of a defined lupus antibody on cognitive function, brain imaging, and the integrity of the blood brain barrier.

PI_NAMEs: MACKAY, MEGGAN  (contact)

PROJECT_TERMS: Adult;Affect;Anatomy;Antibodies;Antibody titer measurement;Area;arterial spin labeling;Assessment tool;Benzodiazepine Receptor;Blood;Blood - brain barrier anatomy;blood-brain barrier permeabilization;Brain;brain dysfunction;Brain imaging;Brain region;Chronic;Clinical;Cognition;Cognitive;Cognitive deficits;cognitive function;cognitive testing;Communities;contrast enhanced;Data;Descriptor;Development;diagnostic development;Diffusion Magnetic Resonance Imaging;disabling disease;Disease;Disease Marker;DNA receptor;Exhibits;Exposure to;Fc Receptor;fetal;fluorodeoxyglucose positron emission tomography;Functional Magnetic Resonance Imaging;Funding;Gadolinium;glial activation;healthy volunteer;Hippocampus;Human;Image;imaging approach;imaging biomarker;Imaging Device;imaging modality;imaging study;Impaired cognition;Impairment;improved;in vivo;Individual;individual patient;Inflammatory;insight;instrumentation;intravenous injection;Investigation;Ionizing radiation;Ligand Binding;Logistics;Long-Term Effects;longitudinal design;Lupus;Magnetic Resonance;Magnetic Resonance Imaging;Measurement;Measures;Mediating;Metabolic;Metabolism;Methods;Microglia;Molecular;mouse model;Multimodal Imaging;multimodality;Mus;N-Methyl-D-Aspartate Receptors;Neurocognitive;neuroinflammation;neuron loss;neurotoxic;neurotoxicity;neurotransmission;non-invasive imaging;novel;novel therapeutic intervention;Pathogenicity;Pathologic;Pathway interactions;Patients;Performance;Peripheral;Positron-Emission Tomography;Process;Proxy;Psychometrics;Radiation;radiotracer;Reporting;Reproducibility;Research Design;response;Rest;Role;Scanning;Serology;Serum;spatial memory;Structure;Synapses;synaptic function;synaptic pruning;Systemic Lupus Erythematosus;targeted biomarker;Testing;Therapeutic;Time;Tracer;treatment strategy;uptake;white matter;white matter change

PROJECT_TITLE: Project 2- Correlating microglial activation with blood brain barrier integrity and neurocognitive performance


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: KAMPALA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: INFECTIOUS DISEASES INSTITUTE

PHR: PROJECT NARRATIVE African transgender women (TGW) are a stigmatized and marginalized population with high HIV incidence, poor engagement in HIV care and suboptimal ART and PrEP use. Multi-level interventions to reduce intersectional stigma and discrimination could improve HIV outcomes for TGW by addressing immediately modifiable stigma drivers, centering TGW at the core of the stigma response, engaging opinion leaders and building partnerships with TGW. Stigma reduction and status-neutral approaches to HIV care have the potential to decrease HIV burden in this population - “the most vulnerable of the vulnerable” - and generate actionable data for scale-up and program implementation.

PI_NAMEs: MUJUGIRA, ANDREW  (contact);NYBLADE, LAURA

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adoption;Adult;Africa South of the Sahara;African;aged;AIDS prevention;antiretroviral therapy;Caring;Catchment Area;Clinic;Clinical;Clinical Trials;community partners;Complementary therapies;Consolidated Framework for Implementation Research;Consultations;Data;Disclosure;Discrimination;Education;Effectiveness;effectiveness evaluation;effectiveness/implementation trial;Empathy;empowerment;Enrollment;Equity;Evaluation;evidence base;experience;Face;Feedback;Focus Groups;Fright;Gender Identity;gender minority;General Population;health assessment;Health care facility;health care settings;Health Personnel;Health Policy;Health Services;Health Status;health training;Healthcare;High Risk Woman;HIV;HIV Infections;Human immunodeficiency virus test;Hybrids;implementation evaluation;implementation intervention;implementation outcomes;improved;Incidence;Individual;informant;Institution;internalized stigma;intersectionality;Intervention;intervention delivery;Interview;Manuals;marginalized population;Measures;men;men who have sex with men;Modeling;multidisciplinary;Outcome;peer;perceived discrimination;pilot test;Population;post intervention;pre-exposure prophylaxis;Prevalence;Prevention;prevention service;primary outcome;programs;Qualitative Methods;Randomized;Research;residence;response;Risk;RNA;Sampling;scale up;secondary outcome;Services;sex;Sex Orientation;social stigma;standard of care;Stigmatization;Surveys;synergism;Tenofovir;Testing;therapy adherence;therapy design;Training;transgender;transgender women;treatment services;Uganda;uptake;Urine;Viral;Waiting Lists;Well in self;Woman;Work

PROJECT_TITLE: Ssimusango: Multi-level intervention for intersectional stigma reduction to improve HIV outcomes for transgender women

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Autism;Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Immunization;Intellectual and Developmental Disabilities (IDD);Lupus;Mental Health;Neurosciences;Pediatric;Pregnancy;Prevention;Women's Health Research

PHR: Project 3 Narrative: We have shown that lupus antibodies, DNRAbs, with specificity for DNA and the N-methyl-D- aspartate receptor can cause death of female fetuses and cognitive impairment in male offspring. We will determine the mechanism of antibodies-mediated fetal brain injury and develop a strategy to protect the fetuses from these antibodies when they are present in maternal circulation.

PROJECT_TERMS: Adult;Adult Children;Affinity Chromatography;Amino Acids;Anti-DNA Antibodies;Antibodies;antibody-dependent cell cytotoxicity;Antigens;autism spectrum disorder;autistic children;Behavior;Behavioral;behavioral impairment;behavioral phenotyping;Binding;Birth;Brain;brain dysfunction;Brain Injuries;Brain Pathology;Brain Stem;C57BL/6 Mouse;Cause of Death;Child;Chimeric Proteins;Circulation;Cognitive;cohort;Complement;Complement 1q;Complement Receptor;Consensus Sequence;cross reactivity;Data;Development;DNA;Exhibits;experience;Exposure to;Extinction;Fc Receptor;Female;fetal;fetal brain injury;Fetal Development;Fetus;flexibility;Fright;Genetic Engineering;Genotype;Goals;Half-Life;Histologic;Human;IgG1;Immunize;Immunoglobulin G;Impaired cognition;Impairment;in utero;Individual;Injury;Learning;Learning Disabilities;Link;Literature;Lupus;male;Maternal antibody;Mediating;Memory;Modeling;Mothers;Mus;mutant;Mutation;N-Methyl-D-Aspartate Receptors;neurodevelopment;neuron apoptosis;Neurons;offspring;Partner in relationship;Pathogenicity;Pathologic;Pathology;patient variability;Patients;Pattern;Peptides;Phenotype;Placenta;Pregnancy;pregnant;prenatal exposure;prevent;Process;Proliferating;Publishing;Reagent;Receptor Signaling;Reporting;Risk;Role;Saline;Secondary to;Serum;Signal Transduction;Specificity;synergism;Systemic Lupus Erythematosus;Testing;Woman;Women's mortality

PROJECT_TITLE: Project 3 - Mechanisms of DNRAb-mediated damage to the fetal brain


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: PITTSBURGH

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Heart muscle cells must be physically connected for proper heart development and function. Protein complexes control the formation and maintenance of these connections and mutations affecting these proteins are linked to heart disease. Understanding how these protein complexes are formed and how they establish cell connections is critical to human health and the focus of this research.

PI_NAMEs: KWIATKOWSKI, ADAM VINCENT (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Actin-Binding Protein;Actins;Adaptor Signaling Protein;Adherens Junction;Adhesions;Adhesives;Affect;Allosteric Regulation;alpha catenin;Architecture;Binding;Biochemical;Biochemistry;Biological;Cadherins;Cardiac Myocytes;cardiogenesis;Cardiomyopathies;Cell Adhesion;Cell Communication;Cell-Cell Adhesion;Cells;Cellular biology;Collection;Complex;Coupling;Cues;Cytoskeletal Filaments;Cytoskeletal Modeling;Cytoskeletal Proteins;Cytoskeleton;Data;Desmosomes;Development;Epithelium;Equilibrium;Experimental Designs;Extracellular Matrix;Foundations;Goals;Grant;Health;Heart;Heart Diseases;heart function;Homeostasis;Human;In Situ;Individual;insight;Intercalated disc;Intermediate Filaments;Knowledge;Lead;Ligand Binding;Ligands;Link;link protein;Maintenance;mechanical force;mechanical signal;Mechanics;Mediating;Membrane;Microfilaments;Molecular;Mutation;Myofibrils;novel therapeutic intervention;operation;Outcome;Output;Peripheral;Property;protein complex;Proteins;Proteomics;Publishing;reconstitution;recruit;Research;resilience;response;Role;Series;Signal Transduction;System;Testis;Thermodynamics;Tissues;tool;transmission process;Vinculin;Work

PROJECT_TITLE: Alpha-catenin function in cardiomyocyte adhesion and cytoskeletal organization

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: DAVIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Diseased tissue is often nonuniform in presentation of disease markers, making localized sampling methods, such as biopsy, at risk for false negatives. Fluorine-based magnetic resonance imaging has potential for full volume, high sensitivity detection of markers since there is no free fluorine in the body to interfere, but, there is a lack of suitable imaging agents. This project explores development of novel nanodisc structures that are <100nm in diameter and thus, ideal for biomarker imaging.

PI_NAMEs: FISCHER, NICHOLAS OLIVER;LOUIE, ANGELIQUE Y (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Affect;Animals;Apolipoproteins;aqueous;Area;Biodistribution;Biological;Biological Markers;Biopsy;Breast Cancer Model;Cell Culture Techniques;Cell Therapy;Cells;cellular imaging;Characteristics;Charge;chelation;Cholesterol;Circulation;Clinical;clinical imaging;Complex;Contrast Media;Detection;detection sensitivity;Development;Diameter;Dimensions;Disease;disease diagnosis;Disease Marker;Drug Delivery Systems;Environment;Fluorine;Fluorocarbons;fluorophore;Formulation;Foundations;Gadolinium;Goals;Hepatocyte;High Density Lipoproteins;Histology;Hydrophobicity;Image;imaging agent;imaging biomarker;imaging probe;imaging study;Immune;Immunologic Surveillance;improved;innovation;interest;Investigation;Label;Lipid Bilayers;Lipids;Liquid substance;Liver;Longitudinal Studies;Macrophage;Magnetic Resonance Imaging;manufacturing scale-up;Membrane;Methods;Microfluidics;mimetics;Modality;Modeling;molecular imaging;Monitoring Clinical Trials;mouse model;Mus;nanodisc technology;nanodisk;nanoemulsion;nanomaterials;nanoparticle;nanosystems;new technology;Noise;novel;nuclear imaging;Oils;particle;Phagocytes;Phagocytosis;physical property;pilot test;Positioning Attribute;Precision therapeutics;Production;Protons;Radiation therapy;Radioisotopes;Reagent;Reticuloendothelial System;Risk;Sampling;Scaffolding Protein;scale up;Signal Transduction;specific biomarkers;Specificity;stoichiometry;Structure;success;Surface;surfactant;System;T-Lymphocyte;targeted biomarker;Techniques;Technology;Testing;Therapeutic;Thick;Tissues;Toxic effect;Toxicity Tests;Tumor Markers;Tumor-associated macrophages;ultrasound;uptake;Vaccines;Validation;Water;Work

PROJECT_TITLE: Nanodisc Platform for 19F-MRI

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-J(03)M]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease;Pediatric;Precision Medicine

ORG_CITY: PULLMAN

ORG_DEPT: PHARMACOLOGY

ORG_NAME: WASHINGTON STATE UNIVERSITY

PHR: Project Narrative: Children are highly vulnerable to unpredictable drug toxicity and drug-drug interactions due to immature drug elimination in this population. The goal of this project is to establish non-invasive biomarkers for predicting renal secretion of drugs and toxicants in children. Successful validation of the phenotypic biomarkers will result in significant public health benefits as they will allow for the development of clinical tests for safer pediatric drug development and clinical use of drugs in children.

PI_NAMEs: PRASAD, BHAGWAT  (contact)

PROGRAM_OFFICER_NAME: SAMEDY BATES, LESLY

PROJECT_TERMS: 17 year old;Acyclovir;Address;Adult;age related;Aminoglycosides;Animals;Anions;Archives;Avena sativa;Biological Markers;biomarker development;biomarker panel;biomarker validation;Blood;Body Surface Area;Body Weight;Cations;Cell Line;Child;Childhood;Cimetidine;Cisplatin;Clinic;Clinical;clinical development;Clinical Research;Clinical Trials;clinically relevant;Data;Dose;drug disposition;Drug Interactions;Drug Kinetics;Drug Metabolic Detoxication;Drug Prescriptions;Drug toxicity;Drug Transport;Drug usage;Enzymes;Excretory function;Funding;Furosemide;glomerular filtration;Goals;Grant;Growth;Half-Life;Health Benefit;Hepatic;Human;In Vitro;Individual;Infant;innovation;Investigational Drugs;Kidney;Knowledge;Liver;liver metabolism;Measures;Mediating;metabolomics;Metformin;Methods;model development;neonate;nephrotoxicity;novel;novel marker;off-label use;Organ;pediatric drug development;Peer Review;Pharmaceutical Preparations;pharmacokinetic model;Phase II Clinical Trials;phenotypic biomarker;Physiological;Physiology;Play;Population;predictive marker;preterm newborn;prevent;Probenecid;Process;Proteins;Proteomics;Public Health;Rattus;Renal clearance function;Renal function;Reporting;response;Role;Sprague-Dawley Rats;Surrogate Markers;Testing;Tissue Sample;Toxic effect;toxicant;Toxin;Tubular formation;United States Food and Drug Administration;uptake;Uremia;Urine;Validation;Vancomycin;Xenobiotics

PROJECT_TITLE: Ontogeny of drug transport


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE The proposed studies are designed to define the in vivo pathogenic role of heterozygous loss of the epigenetic modifier KMT2D in medulloblastoma genesis using mouse models and to provide epigenetic and mechanistic insights into how heterozygous KMT2D loss promotes medulloblastoma. Because KMT2D is one of the most frequently mutated genes in human medulloblastoma and a majority of KMT2D mutations are heterozygous, our epigenetic and mechanistic findings from the proposed studies will be fundamental to a better understanding of the molecular basis of human medulloblastoma and be beneficial for development of a strategy for therapeutic intervention of human medulloblastoma.

PI_NAMEs: LEE, MIN GYU  (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: Acceleration;AKT1 gene;Alleles;Apoptosis;Brain;Brain region;cancer type;Cell Proliferation;Cells;Cerebellum;Characteristics;ChIP-seq;clinically relevant;Data;design;Development;DNA Sequence;DNA Sequence Alteration;Enhancers;Epigenetic Process;epigenetic regulation;epigenomics;Equilibrium;Future;G Protein-Coupled Receptor Signaling;Gene Expression;Gene Expression Regulation;gene interaction;Genes;Genetic Transcription;Genetically Engineered Mouse;genome-wide;Goals;granule cell;Heritability;Heterozygote;histone demethylase;Histone H3;histone methylation;histone methyltransferase;Histones;Human;in vivo;Induced Neurons;insight;Loss of Heterozygosity;LoxP-flanked allele;Lysine;Malignant - descriptor;Mathematics;Mediating;Medulloblastoma;Methylation;Methyltransferase;MLL2 gene;Modeling;Molecular;Motor;motor control;mouse model;Mus;Mutate;Mutation;NCOR2 gene;neoplastic cell;nestin protein;Neuronal Differentiation;Neurons;Nucleic Acid Regulatory Sequences;Oncogenic;Oncoproteins;Oxidation-Reduction;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pattern;Pediatric Neoplasm;Phenotype;Phosphotransferases;Post-Translational Protein Processing;Primary Brain Neoplasms;Process;programs;promoter;PTCH gene;rational design;Reporting;Repression;Role;SHH gene;side effect;Signal Pathway;Signal Transduction;spatiotemporal;stem cells;Testing;Therapeutic;Therapeutic Intervention;Transcription Coactivator;Transcriptional Regulation;Tretinoin;tumor;Tumor Promotion;Tumor Suppressor Genes;Tumor Suppressor Proteins;tumorigenesis

PROJECT_TITLE: Heterozygous KMT2D Loss and Medulloblastoma

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Complementary and Integrative Health;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: NEUROSURGERY

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: Promoting remyelination is an important area of research. Here, we will test a novel idea that muscle building supplement HMB binds to peroxisome proliferator-activated receptor β (PPARβ) and that HMB and its precursor L-leucine, an essential amino acid, promote maturation of oligodendroglial progenitor cells and stimulate remyelination in animal models of demyelination via PPARβ. This study will enhance the possibility of promoting remyelination and treating patients with multiple sclerosis and other demyelinatingdisorders with L-leucine and its metabolite HMB as primary or adjunct therapy. 1

PI_NAMEs: PAHAN, KALIPADA  (contact)

PROGRAM_OFFICER_NAME: TUTTLE, ALEXANDER H

PROJECT_TERMS: Animal Model;Area;Axon;beta-hydroxyisovaleric acid;Binding;Brain;brain cell;Clinical;Cuprizone;Demyelinating Diseases;Demyelinations;Diffuse;Essential Amino Acids;Exercise;Experimental Autoimmune Encephalomyelitis;Human;improved;Knowledge;Leucine;Ligand Binding Domain;Ligands;Metabolism;Microglia;Modeling;Motor Activity;motor function improvement;Multiple Sclerosis;multiple sclerosis patient;Muscle;muscle strength;Myelin;myelination;novel;Nuclear Hormone Receptors;Nuclear Translocation;Oligodendroglia;Outcome;Pathologic;Performance;Peroxisome Proliferator-Activated Receptors;Physiological;receptor;remyelination;Research;Role;side effect;Skeletal Muscle;stem cells;Testing

PROJECT_TITLE: Muscle building supplement HMB for remyelination


NIH_SPENDING_CATS: Antimicrobial Resistance;Assistive Technology;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Nanotechnology;Prevention

ORG_CITY: TEANECK

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: FAIRLEIGH DICKINSON UNIVERSITY

ORG_STATE: NJ

PHR: NARRATIVE  Despite valiant efforts for infection prevention and treatment with antibiotics or surface coatings of antimicrobial cocktails, the number of infections associated with medical devices has increased drastically due to the emergence of resistant bacteria. Current failing approaches can only exacerbate the emergence and spread of antibiotic-resistance, but have led our group to develop antibiotic-free, anti-infection cross-linked nanocoatings as viable surface modifications with great potential to dramatically improve quality of life for people who now suffer dire contamination complications.

PI_NAMEs: TRABA, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: acrylic acid;American;Anti-Bacterial Agents;Anti-Infective Agents;Antibiotic Resistance;Antibiotics;antimicrobial;Argon;Bacteria;Bacterial Adhesion;Bacterial Antibiotic Resistance;Bacterial Drug Resistance;bacterial resistance;Binding;Biocompatible Materials;Biological;Biological Assay;biomaterial compatibility;Catheters;Cell Line;Cell membrane;Cells;Cessation of life;Charge;Clinical;Coculture Techniques;Collaborations;combat;Complex;complex biological systems;Copper;cost;Coupled;Cross Infection;crosslink;Cytolysis;Data;density;design;Devices;Dryness;Engineering;Environment;Enzymes;Erythrocytes;Escherichia coli;Excretory function;Exposure to;Extravasation;Funding;Future;Grant;Health Personnel;healthcare burden;Hospitals;Human;human tissue;Immobilization;Impairment;implantable device;improved;In Situ;In Vitro;in vivo;Infection;Infection prevention;innovation;Iron;Knowledge;Lead;Length;Leukocytes;Longevity;macromolecule;Medical;Medical Care Costs;Medical Device;medical implant;Medicine;Methicillin Resistance;methicillin resistant Staphylococcus aureus;Microbial Biofilms;Microfluidics;microorganism;Modeling;Modern Medicine;Modification;Monitor;monomer;nanocoating;nanoparticle;operation;Patients;Persons;Plasma;Polymers;prevent;Prevention;Process;programs;Prosthesis;Proteins;Protocols documentation;Public Health;Quality of life;Recurrence;Research;Safety;Silver;Specificity;Stains;Staphylococcus aureus;Staphylococcus epidermidis;STEM student;Students;sugar;Surface;surface coating;System;Techniques;Technology;Testing;Toxic effect;United States;Universities;Visit;Work

PROJECT_TITLE: Plasma-initiated Cross-linked Nanocoatings asAnti-infection Agents

STUDY_SECTION: INN

STUDY_SECTION_NAME: Innovations in Nanosystems and Nanotechnology Study Section [INN]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Hispanic adolescents are disproportionately burdened by type 2 diabetes and social determinants of health that negatively impact health behaviors and contribute to the development of this costly disease. This study will adapt a 12-week, evidence-based, culturally-grounded diabetes prevention program for delivery via telehealth and will test the feasibility, acceptability, and preliminary efficacy of the telehealth intervention. This study will provide novel information on the use of telehealth to reach and engage high-risk youth from vulnerable, health disparate communities in disease prevention efforts.

PI_NAMEs: SOLTERO, ERICA  (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: Accelerometer;acceptability and feasibility;Address;Adolescent;Adult;Age;Area;Award;behavior change;Body mass index;Body Weight decreased;Cellular Phone;Child Care;Childhood;Collaborations;Communication;community clinic;community engaged approach;Cost of Illness;COVID-19;Data Collection;design;Development;Devices;Diabetes Mellitus;Diabetes prevention;diabetes prevention program;diabetes risk;digital;Disease;Disease Outcome;disorder prevention;Disparity;Education;Educational workshop;Effectiveness;Ensure;evidence base;Exhibits;experience;Family;fasting glucose;feasibility testing;Feedback;field study;fitbit;Focus Groups;Foundations;Funding;Glycosylated hemoglobin A;Goals;Health behavior;Health behavior and outcomes;health care delivery;health disparity populations;Health education;Healthcare;high risk;Hispanic;Home;improved;innovative technologies;Insulin;Insulin Resistance;insulin sensitivity;Insurance Coverage;Internet;Intervention;intervention delivery;Interview;K-Series Research Career Programs;Life Expectancy;lifestyle intervention;lifetime risk;meetings;Mentors;Mentorship;Methods;Minority;minority children;multidisciplinary;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;nutrition;nutrition education;Obesity;Outcome;Parents;Participant;Persons;Phase;Physical activity;Population;Prediabetes syndrome;prevent;Prevention;Prevention program;Prevention strategy;preventive intervention;Process;programs;Quality of life;Randomized;recruit;remote delivery;Reporting;Research;Research Personnel;Sampling;Schedule;Science;Scientist;Self Determination;Self Perception;Services;skills;social determinants;social health determinants;Surveys;Technology;technology development;technology intervention;Telecommunications;telehealth;telehealthcare;Testing;Text Messaging;theories;tool;Training;Transportation;treatment as usual;Treatment Efficacy;United States Centers for Medicare and Medicaid Services;usability;usual care arm;vulnerable community;Work;Youth

PROJECT_TITLE: ADAPTING AND ASSESSING THE FEASIBILITY OF A TELEHEALTH DIABETES PREVENTIONPROGRAM FOR HISPANIC ADOLESCENTS


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Rehabilitation

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Narrative The proposed trial has significant public health relevance as it aims to determine the effectiveness of an increasingly popular mind-body therapy of yoga, its effects on cognitive functioning and its potential to remediate and improve cognitive health among older adult populations. Given the modifiable nature of yoga and its suitability for older adults and individuals with different functional abilities, it seems to be a promising cost-effective and feasible mode of activity to promote cognitive, psychological as well as physical well-being in older adults.

PI_NAMEs: GOTHE, NEHA PRAVIN (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: active control group;Activities of Daily Living;Adult;Aerobic;Aerobic Exercise;Affect;Age;age related chronic disease;Age Years;Age-associated memory impairment;Aging;Alternative Therapies;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Anxiety;Area;arm;Attention;behavior measurement;Behavioral;Biological Markers;Blood;Brain;brain health;Brain imaging;Brain-Derived Neurotrophic Factor;Breathing;cardiorespiratory fitness;cardiovascular fitness;Chronic;Cognition;Cognitive;cognitive benefits;cognitive function;cognitive performance;Collaborations;comorbidity;comparative efficacy;Complementary Health;Complementary Medicine;Control Groups;cost effective;Creativeness;Effectiveness;effectiveness evaluation;executive function;Exercise;exercise intervention;exercise program;exercise training;Exhibits;experience;fitness;fitness test;follow-up;Functional Magnetic Resonance Imaging;Future;group intervention;Health;Health Care Costs;Hippocampus;Hour;Hydrocortisone;Impaired cognition;improved;indexing;inflammatory marker;interest;Interleukin-6;Intervention;Investigation;Link;Low Back Pain;Magnetic Resonance Imaging;Maintenance;Measures;Mediating;Memory;Mental Depression;middle age;Mind-Body Intervention;mind/body;Modality;molecular marker;Nature;Neurobiology;Neurocognitive;neurocognitive test;Neurons;neuropathology;Neuropsychology;Neurosciences;Non-Insulin-Dependent Diabetes Mellitus;older adult;Older Population;Outcome;Participant;Performance;Personal Satisfaction;Persons;Physical activity;Physiological;pilot trial;Population;Prefrontal Cortex;Prevalence;prevent;Preventive;Productivity;psychologic;Public Health;public health relevance;Randomized;Randomized, Controlled Trials;Recording of previous events;remediation;Research;Research Personnel;Role;Serum;Single-Blind Study;skills;Speed;Stress;Stretching;Structure;Testing;Therapeutic;Time;Training;Walking;Yoga

PROJECT_TITLE: Yoga, Aerobic and Stretching Exercise Effects on Neurocognitive Performance: A Randomized Controlled Trial


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative The study will advance HIV science on the feasibility and acceptability of strategies to reduce internalized and intersectional stigma experiences at the intra and interpersonal level, and ways to leverage assets such as anti- stigma trained nurses to swerve intersectional stigma at the healthcare facilities to improve HIV outcomes among YSMM from resource-limited settings. This study will also show how building capacity for HIV self-testing alongside addressing intersectional stigma through community level partnership, culturally relevant interventions can increase HIVST uptake among YSMM. The study will also determine in the feasibility of scaling up an adapted 3MV in a clustered randomized control trial for young sexual minority men and slum communities in Ghana, West Africa and other stigmatized and marginalized communities elsewhere, and its utility to continue to positively influence behavioral change among SMM across lifespan and geographical setting.

PI_NAMEs: ABU-BA'ARE, GAMJI RABIU  (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Africa;African ancestry;Age;AIDS prevention;Amendment;Behavior;behavior influence;Black race;Caring;Clinic;Communities;community organizations;Diagnostic Reagent Kits;Discrimination;Economics;Ensure;evidence based guidelines;experience;Face;Feedback;gender expression;Geography;Ghana;Health;Health care facility;Health Care Visit;high risk population;HIV;HIV Infections;Home;Human immunodeficiency virus test;implementation strategy;improved;Intervention;Interview;Knowledge;life span;Location;Manuals;marginalized community;Measures;men;Modeling;Modification;Multiple Partners;Nurses;Outcome;Persons;post intervention;Preparation;Prevalence;preventive intervention;primary outcome;Privacy;Provider;Randomized, Controlled Trials;Recommendation;Research;Research Personnel;Resource-limited setting;Risk;scale up;Science;Scientific Advances and Accomplishments;secondary outcome;self testing;Sexual and Gender Minorities;sexual minority men;Slum;social;social stigma;socioeconomics;Stigmatization;Surveys;Testing;testing uptake;Training;transactional sex;uptake;Voice;willingness;Work;young adult

PROJECT_TITLE: Adaptation and feasibility of Many Men Many Voices (3MV), an HIV prevention intervention to reduce intersectional stigma and increase HIVST among YSMM residing in Ghanaian slums

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Autoimmune Disease;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE In the past two decades, we have seen a paradigm shift in our understanding of the mechanisms underlying autoimmune and autoinflammatory diseases. To continue generating key insights and developing novel therapeutic strategies will require the next generation of scientists to have broad, multidisciplinary understanding and training in the latest advanced technologies. The Training in the Molecular Basis of Autoimmunity and Autoinflammation develops predoctoral investigators in these crucial areas by bringing together highly skilled and collaborative training faculty from multiple disciplines, with the ultimate goal of developing effective treatments, and eventually cures, for these debilitating diseases.

PI_NAMEs: FITZGERALD, KATHERINE A. (contact);MARSHAK-ROTHSTEIN, ANN

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative  The proposed study offers a prospective digital cohort study to quantify how socioecological factors impact changes in HIV care outcomes for Black sexual minority men (BSMM). This theory-guided approach will test the effectiveness of various recruitment methods then validate commonly accepted scales among the target population prior to initiating the longitudinal analyses. The results of this study have crucial implications for understanding the barriers and supports for HIV care outcomes for this highly marginalized population.

PI_NAMEs: DANGERFIELD II, DEREK TRAMEL (contact)

PROGRAM_OFFICER_NAME: STIRRATT, MICHAEL JAMES

PROJECT_TERMS: acceptability and feasibility;Accounting;Adherence;Adolescent;age difference;age effect;age group;Baltimore;Black race;care outcomes;Caring;Chi-Square Tests;Cities;cohort;Cohort Studies;Collaborations;Continuity of Patient Care;COVID-19;Data;design;differences in access;digital;Drug usage;Drug user;Economics;effectiveness testing;Enrollment;epidemic preparedness;Epidemiology;Equity;experience;Generations;Goals;health care service organization;High Prevalence;HIV;improved;improved outcome;Incidence;Knowledge;Life Cycle Stages;Literature;Locales;longitudinal analysis;Longitudinal Studies;Maps;marginalized population;Measures;Medical;men;Mental Depression;Methods;Modeling;novel;Outcome;Participant;Pattern;Phase;Philadelphia;Population;prospective;Prospective cohort;Prospective Studies;Prospective, cohort study;Psychometrics;racism;recruit;Research;Research Personnel;Resources;Risk;Sampling;Service delivery model;sexual minority men;Sexuality;social stigma;Surveys;Target Populations;telehealth;theories;transgender women;treatment adherence;trend;United States National Institutes of Health;Update;Victimization;Viral;Washington;Work

PROJECT_TITLE: Identifying socioecological profiles that impact changes in care outcomes among Black Sexual minority men living with HIV


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

PHR: Project Narrative Rising rates of drug resistance and mortality from fungal infections pose major threats to national health and safety. A major culprit for the increased virulence in pathogens such as Candida albicans, auris, and glabrata is a class of proteins belonging to the MRP family of ABC transporters. This proposal aims to identify the functional and structural determinants of how fungal cells regulated MRP transporters during infection by using hybrid approaches in biochemistry, yeast biology, and cryo-EM to gain invaluable insights into new avenues for preventing drug-resistant infections before they can develop.

PI_NAMEs: TOMASIAK, THOMAS MICHAEL (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: ABCB1 gene;Adopted;Allosteric Regulation;Amino Acids;amphiphilicity;anti-fungal agents;Architecture;ATP-Binding Cassette Transporters;Binding;Binding Sites;Biochemical;Biochemistry;biological adaptation to stress;Biological Assay;Biology;Biophysical Process;Biophysics;Cadmium;Candida;Candida albicans;Carrier Proteins;Cell Line;Cell Survival;Cells;Cellular biology;Cessation of life;Charge;Clinical;Complex;crosslink;Cryoelectron Microscopy;Data;Defect;Disease;Docking;drug development;Drug Metabolic Detoxication;Drug resistance;Drug Tolerance;effective therapy;Electron Spin Resonance Spectroscopy;Electronics;Electrostatics;Elements;Failure;Family member;flexibility;Foundations;Future;Glutathione;glutathione transporter;Goals;Health;HIV;Homeostasis;Homologous Gene;Hybrids;improved;In Vitro;in vivo;Infection;innovation;insight;Integral Membrane Protein;interdisciplinary approach;Investigation;Knock-out;Knowledge;Light;Link;lipid transport;Lipids;Maps;Mass Spectrum Analysis;Mediating;member;Membrane;Membrane Proteins;Microbial Biofilms;Modeling;Molecular;Molecular Conformation;Molecular Mimicry;Monitor;Morphology;mortality;multi drug transporter;Multi-Drug Resistance;Multiple Fungal Drug Resistance;mutant;Mycoses;Natural Killer Cells;Nature;Nucleotides;Oxidants;pathogen;pathogenic fungus;Pathway interactions;Pharmaceutical Preparations;Phosphorylation;Play;prevent;Protein Biochemistry;Protein Family;protein purification;Proteins;Publishing;Regulation;Resistance;Role;Saccharomyces cerevisiae;Safety;Site;stress tolerance;structural determinants;Structure;System;Testing;Therapeutic;therapeutic development;therapeutic target;thermostability;Treatment Efficacy;Tuberculosis;Vacuole;Virulence;Virulence Factors;Work;Yeasts

PROJECT_TITLE: ATP Binding Cassette (ABC) Transporters in Fungal Drug Tolerance

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Contraception/Reproduction;Genetics;Human Genome;Machine Learning and Artificial Intelligence

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Mosaic mutation in sperm is an important source of new mutations and underlies sporadic genetic risk for congenital diseases in offspring, this proposal aims to uncover how mutations in single sperm look like, what impacts they have, and how they accumulate with age. I will obtain training in the related fields of reproductive medicine and human subjects, as well as develop both computational and experimental technologies to study the genomes of individual single sperm and generalize them to other studies. The proposed project will not only advance novel technologies for the analysis of single sperm genomes and detect mosaic variants but will also advance a fundamental understanding of paternal non-clonal sperm mosaicism and predict its significant contributions to child health.

PI_NAMEs: YANG, XIAOXU  (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Address;Age;age effect;age related;age-related disease;aged;Aging;Algorithms;Award;base;Benchmarking;Biological;Biotechnology;Brain;burden of illness;career;career development;Categories;Cells;Chemical Exposure;Child;Child Health;computational pipelines;Computer software;Congenital Disorders;Data;Data Set;Daughter;de novo mutation;deep learning;density;Detection;Diploidy;Disease;DNA amplification;DNA Sequence Alteration;DNA sequencing;Embryonic Development;Environmental Exposure;experimental study;Fathers;Focus Groups;Foundations;Future;Generations;Genetic;Genetic Risk;Genome;genome sequencing;Genome Stability;Genomics;Germ Cells;Goals;Haploidy;Haplotypes;Human;Human Biology;Human Genome;human subject;Human Subject Research;improved;Individual;interdisciplinary approach;Job Application;Knowledge;Lead;male;Measures;men;Mental disorders;Mentors;Metabolism;Methods;Modeling;mosaic;mosaic variant;Mosaicism;Mutation;Mutation Detection;Natural Selections;Nature;Nervous System Disorder;new technology;next generation;next generation sequencing;novel;offspring;Outcome;Parents;Paternal Age;Pattern;Performance;Phase;Population;Positioning Attribute;Postdoctoral Fellow;pressure;Publishing;Recording of previous events;recruit;recurrent neural network;Reporting;Reproductive Medicine;Reproductive Sciences;Research;Research Personnel;Risk;Sampling;Sensitivity and Specificity;Shapes;single cell genomics;Somatic Mutation;Source;sperm cell;Technology;Training;training data;transmission process;Variant;whole genome;young man

PROJECT_TITLE: Understanding genomic stability betweengenerations by assessing mutational burdens in single sperms

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_DEPT: DERMATOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Information from this project will impact on our understanding of the functions of LRRK1/ID3, a novel signaling axis in promoting limbal epithelial stem cell homeostasis. These studies will lead to an improvement in preserving stem cells in ex vivo cultures of limbal epithelial cells. Another benefit from this research will be the development of innovative treatment regimens focused on the modulation of ID3 expression in patients with diseases with compromised limbal epithelial stem cell homeostasis.

PI_NAMEs: PENG, HAN  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: 3-Dimensional;Affect;Alkalies;Basal Cell;Binding;Biological Assay;Biological Models;biomarker evaluation;Cell Maintenance;cell motility;Cells;Cornea;Corneal Diseases;corneal epithelial stem cells;corneal epithelium;Data;Defect;Development;Diabetes Mellitus;diabetic;Disease;Ensure;Epithelial Cells;epithelial stem cell;Epithelium;experimental study;Foundations;Functional disorder;gain of function;Genes;Goals;Heterogeneity;Homeostasis;Human;Impaired wound healing;improved;In Vitro;in vivo;innovation;insight;Intervention;Investigation;Knockout Mice;Knowledge;Label;Leucine-Rich Repeat;limbal;loss of function;Maintenance;Mus;mutant;Mutation;novel;novel therapeutics;overexpression;Pathogenesis;Pathway interactions;Patients;Peripheral;pharmacologic;Phosphotransferases;Play;Population;postmitotic;preservation;Primary Cell Cultures;progressive myositis ossificans;Proliferating;promoter;Property;Proteins;Regulation;Regulatory Pathway;Research;response;Role;Scheme;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Sjogren's Syndrome;stem;stem cell biology;stem cell biomarkers;stem cell homeostasis;stem cell population;stem cells;Stratum Basale;Stress;success;Testing;Tissues;transcription factor;transcriptome;transcriptome sequencing;Translating;translational potential;Transplantation;Treatment Protocols;Undifferentiated

PROJECT_TITLE: Single-cell RNA sequencing reveals novel regulatory pathways in maintaining limbal epithelial stem cell homeostasis


ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PUBLIC HEALTH SIGNIFICANCE Cryptococcus neoformans is a fungus that causes a devastating form of meningitis that occurs most commonly in HIV-infected patients with profound T cell deficiency, but also occurs in patients with organ transplants, on biologics, and people with no apparent immune deficiency. Although anti-retroviral therapy has reduced the risk of cryptococcal meningitis (CM) in resourced areas, CM continues to ravage HIV-infected patients in Africa, Asia and other areas, even with increased availability of anti-retroviral and anti-fungal therapy. The 6- month survival of CM in resource-limited settings is 45-55%. This is worse than glioblastoma multiforme (66% 2-year survival). At present, there is no way to identify patients who will develop cryptococcosis. The goal of this application is to identify a risk profile to help determine which patients are at risk for CM. This will have a significant impact on prevention, diagnosis, and care of patients with CM and be a major public and global health advance.

PI_NAMEs: PIROFSKI, LIISE-ANNE  (contact)

PROGRAM_OFFICER_NAME: RADKE, JOSHUA BRYAN

PROJECT_TERMS: Address;Africa;Anti-Retroviral Agents;Antibodies;Antibody Repertoire;Antibody-mediated protection;Antifungal Therapy;antigen test;Antigens;antiretroviral therapy;Architecture;Area;Asia;B cell repertoire;B-Lymphocyte Subsets;B-Lymphocytes;Bacteria;beta-Glucans;Binding;Biological Markers;Biological Products;Biological Response Modifier Therapy;Biology;Brain;brain control;Carbohydrates;Cell Wall;Cells;Cessation of life;Clinical;Complication;Cryptococcal Meningitis;Cryptococcosis;Cryptococcus;Cryptococcus neoformans;Data;Development;Diagnosis;differential expression;Disease;Effector Cell;Encapsulated;Exposure to;feature selection;fungus;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic Transcription;Glioblastoma;global health;Glucans;glucuronoxylomannan;Goals;Growth;high risk;HIV;Homologous Gene;Human;Human immunodeficiency virus test;human monoclonal antibodies;immune reconstitution;Immunity;immunodeficiency;Immunoglobulin G;Immunoglobulin M;Immunosuppression;Immunotherapy;improved;In Vitro;Incidence;Inflammatory;inhibiting antibody;insight;interest;Iris;Knowledge;laminaran;Link;Lung;Machine Learning;Measurement;Measures;Mediating;Memory;Memory B-Lymphocyte;Meningitis;microbial;Modeling;Monoclonal Antibodies;Morphology;mortality;mouse model;Mouse Strains;Mus;natural antibodies;organ transplant recipient;Organ Transplantation;Pathogenesis;Pathway interactions;Patient Care;Patients;Peripheral Blood Mononuclear Cell;Persons;Phagocytosis;Phenotype;Plasma;Play;Polysaccharides;predictive modeling;Prevention;Principal Investigator;Prognosis;programs;Public Health;random forest;Recurrence;Resistance;Resource-limited setting;Resources;response;Risk;risk prediction;Role;Serology;Serum;Solid;South Africa;Specificity;Statistical Models;stem;Syndrome;T-Lymphocyte;Testing;tool;transplantation therapy;uptake;vaccine development;Vaccines;Virulence

PROJECT_TITLE: Antibodies, B cells and resistance to human cryptococcosis

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Rehabilitation;Stroke

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because stroke is a leading cause of long-term disability among older adults and communication impairments resulting from stroke have a significant negative impact on quality of life. By seeking to better understand post-stroke aphasia, this project lays the groundwork for development of new interventions, and aligns with NIDCD’s priority areas 1 (understanding normal function), 2 (understanding diseases), and 3 (improving diagnosis, treatment, and prevention).

PI_NAMEs: FAROQI SHAH, YASMEEN  (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Address;Agrammatism;Anatomy;Aphasia;Architecture;Area;Brain region;Broca Aphasia;Chronic;Clinical effectiveness;cognitive process;Communication;Communication impairment;comorbidity;Data;Development;Diagnosis;Dimensions;Disease;Electromyography;Foundations;Goals;High-dimensional Modeling;Impairment;improved;Individual;Inferior frontal gyrus;innovation;Intervention;Language;Language Disorders;language impairment;Left;Lesion;lexical;Linguistics;Long term disability;Magnetoencephalography;Measurement;Modeling;Morphology;National Institute on Deafness and Other Communication Disorders;Nerve Degeneration;neural;neural model;Neuroanatomy;Neurocognitive;neuromechanism;neurophysiology;novel;Occupations;older adult;Outcome;Participant;Personal Communication;Persons;post intervention;post stroke;Prevention;Process;Production;programs;Public Health;Quality of life;Research;Research Proposals;Retrieval;Semantics;spatiotemporal;Specific qualifier value;Speech;Speed;Stroke;stroke survivor;stroke-induced aphasia;symptom cluster;Symptoms;syntax;Testing;theories;Time;Variant;Work

PROJECT_TITLE: Neurocognitive Mechanisms of Sentence Production Impairment in Aphasia

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Physical Injury - Accidents and Adverse Effects

ORG_CITY: NEW YORK

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because understanding the complex interactions between vocal fold mucosal injury and the underlying laryngeal muscle will lead to improved diagnosis and treatment of voice disorders. Thus, the proposed research is relevant to the NIH’s mission and, specifically, to that of the NIDCD to research processes of the disordered voice and improve the life of individuals who have communication impairments.

PI_NAMEs: JOHNSON, AARON MATTHEW (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acoustics;Acute;Affect;American;Autocrine Communication;Benign;Big Data;cell type;Cells;Chronic;Chronic Laryngitis;Cicatrix;Classification;Clinical;Clinical Research;Coculture Techniques;Communication impairment;Complex;cost;Data;Development;Diagnosis;disability;Dysphonia;economic cost;efficacious treatment;Etiology;Event;experience;experimental study;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;Female;Fibroblasts;Foundations;Functional disorder;Future;Genes;Goals;healing;Health;Histology;Homeostasis;improved;In Vitro;in vivo;Individual;Inflammation;Inflammation Mediators;Inflammatory;injured;Injury;innovation;insight;Intervention;Investigation;Laboratories;Lamina Propria;Laryngeal Mucosa;Laryngeal muscle structure;Larynx;Lead;Lesion;Life;life span;Literature;Macrophage;male;medical specialties;Methodology;Mission;Motivation;Motor;Mucous Membrane;Muscle;Muscle function;muscle repair;Muscle Tension;Myoblasts;Myosin Heavy Chains;National Institute on Deafness and Other Communication Disorders;neuromuscular;novel;Paracrine Communication;Pathology;Patient observation;Patients;Performance;pharmacologic;Phenotype;Population;Process;Proteins;Proteomics;Public Health;Rattus;Reporting;Research;response;response to injury;Rodent;Rodent Model;screening;Signal Transduction;Skeletal Muscle;Structure;targeted treatment;Therapeutic;Thinking;Thyroarytenoid Muscle;Time;Tissues;Trauma;treatment optimization;Ultrasonics;United States National Institutes of Health;Up-Regulation;vocal cord;vocalization;Voice;Voice Disorders;Wages;Work

PROJECT_TITLE: Effect of vocal fold injury on laryngeal muscle dysfunction

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Narrative All eukaryotic cells use the RNA quality control pathways Nonsense-mediated mRNA decay to recognize and degrade faulty transcripts. NMD also restricts the infection with many RNA viruses, but the mechanisms of antiviral NMD are poorly understood. We seek to uncover the protein-protein and protein-RNA interaction network behind antiviral NMD, with the goal to gain new insight into cell-autonomous antiviral defense strategies and cellular gene regulation control.

PI_NAMEs: STECKELBERG, ANNA-LENA  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Address;Alpha Virus;Binding;Cell Differentiation process;Cell Physiology;Cells;Cellular Stress;Coronavirus;Culicidae;Ensure;Eukaryotic Cell;fighting;Flavivirus;Gene Expression;Gene Expression Regulation;Goals;high throughput screening;Homeostasis;Human;Infection;insight;interdisciplinary approach;Link;Mediating;Messenger RNA;Modeling;mRNA Decay;obligate intracellular parasite;Pathogenicity;Pathway interactions;Phenotype;premature;Proteins;Quality Control;Ribosomes;RNA;RNA Biochemistry;RNA Viruses;RNA-Protein Interaction;Role;Terminator Codon;Transcript;Viral;Viral Proteins;viral RNA;virology;Virus;Virus Diseases;Zika Virus

PROJECT_TITLE: Understanding the antiviral roles of acellular RNA quality control pathway

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-J(55)R]