NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Studies of brain neuroplasticity during learning and memory have been so far restricted to animal research. A significant reason has been the lack of non-invasive imaging technology to probe neuroplasticity with high biological specificity. This project aims to develop and validate a non-invasive marker of neuroplasticity during learning in the human hippocampus subfields of living humans with the latest ultra-high gradient strength diffusion Magnetic Resonance Imaging technology. The marker can be used to detect early signs of pathological remodeling of the hippocampus in Alzheimer’s disease or assess the efficacy of invasive tools for memory function repair.

PI_NAMEs: RAMOS LLORDEN, GABRIEL  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, KARI ANNE

PROJECT_TERMS: Alzheimer's Disease;Anatomy;Animal Experimentation;Animals;Architecture;Award;behavior test;Biological;Boston;Brain;BRAIN initiative;Cell Physiology;Cells;Chemicals;Cognition;cognitive neuroscience;connectome;Cues;Data;Deep Brain Stimulation;density;dentate gyrus;design;diagnostic tool;Diffusion;Diffusion Magnetic Resonance Imaging;Dimensions;Early Diagnosis;efficacy evaluation;expectation;Foundations;Functional Magnetic Resonance Imaging;Funding;gray matter;Hippocampus;Human;Image;Imaging technology;in vivo;Individual;Institution;Knowledge;Learning;Link;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Maps;mathematical model;Memory;memory encoding;Memory impairment;Mentors;Methodology;Methods;millimeter;Modeling;Molecular;neural;Neurites;Neuroanatomy;Neurobiology;neuroimaging;neuronal cell body;Neuronal Plasticity;next generation;non-invasive imaging;Pathologic;Performance;Phase;Physiology;programs;Property;Protocols documentation;reconstruction;repair function;repaired;Research;Resolution;response;Rodent;Role;Route;Signal Transduction;skills;spatial memory;Specificity;Structure;System;Techniques;Technology;Time;tool;Training;Universities;Validation;way finding

PROJECT_TITLE: Revealing the Functional and Microstructural Response of Human Hippocampus to Spatial Learning with High-Gradient Strength Diffusion MRI

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-P (02)]


ADMINISTERING_IC: VA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: SYRACUSE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: SYRACUSE VA  MEDICAL CENTER

ORG_STATE: NY

PHR: The project is relevant to veterans’ health because it will develop a novel wearable, portable device to help veterans with spasticity stretch themselves without additional human assistance. Manual stretching is a primary treatment to manage spasticity and can provide relief from spasms and joint stiffness, and normalize muscle tone. However, providing on-demand, reliable manual stretching is caregiver intensive. The project integrates a wearable exoskeleton and its control system to apply automated forces moving the legs at custom stretching rates while veterans lie on a bed and are sitting down. The study can lead to the development of a safer, personalized on-demand stretching tool compared to manual stretching provided by caregivers. This may provide the patient with more frequent stretching to ultimately decrease the burden of spasticity. The study examines the feasibility and performance of the device in veterans with spasticity.

PI_NAMEs: BROSE, STEVEN W. (contact)

PROJECT_TERMS: Activities of Daily Living;Address;Adverse effects;Algorithms;Ankle;Articular Range of Motion;Beds;Botox;Caregiver Burden;Caregivers;Chronic;Client satisfaction;Clinic;Clinical;clinical care;Contracture;COVID-19;Custom;Data;decubitus ulcer;design;Development;Devices;Disease;Dose;Drowsiness;Effectiveness;Equilibrium;Exercise;exoskeleton;experience;falls;Family;Family member;Family Nursing;Feasibility Studies;Feedback;foot;functional electrical stimulation;Future;Goals;Health;Hip Joint;Home;Hospitals;Human;implementation barriers;improved;Individual;Injury;joint stiffness;Joints;Knee;Knee joint;Leg;light weight;Limb structure;Long-Term Effects;Manipulative Therapies;Manuals;Measures;Modality;motor neuron injury;Motor Neurons;Movement Disorders;Muscle;Muscle Contraction;Muscle Tonus;Muscle Weakness;Myalgia;neurosurgery;novel;Nurses;Oral;Pain;pain reduction;Participant;Patients;Performance;Persons;Pharmaceutical Preparations;Play;portability;Positioning Attribute;Posture;Predisposition;Quality of life;Questionnaires;rehabilitation strategy;Research;Role;Safety;satisfaction;Sedation procedure;Self-Help Devices;side effect;Skeletal Muscle;Skin injury;Sleep;Spasm;spasticity;Spinal cord injury;Stretching;Stroke;Supination;Supine Position;surgical risk;System;Techniques;Technology;Testing;Time;tool;Traumatic Brain Injury;Veterans;vibration;Visit;volunteer;Walking;wearable device

PROJECT_TITLE: Leg Stretching Using a Controllable Wearable Exoskeleton on Demand for People with Spasticity

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Neurosciences;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Glioblastoma is the most common primary brain tumor in adults and is uniformly fatal. We have identified a rare population of tumors cells that may be responsible for treatment resistance resulting from signaling/interactions within its local tumor microenvironment. We now seek to study these cells and their interactions in hopes that inhibiting their signaling mechanisms will result in treatment sensitivity and lead to the identification of novel therapies for patients.

PI_NAMEs: AL-HOLOU, WAJD  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Adult;Aftercare;Automobile Driving;Award;Binding;Bioinformatics;Biological;Biological Models;Biometry;Blood Vessels;Cancer Biology;Cancer Center;cancer genomics;cancer type;career;career development;CD97 gene;Cell Communication;Cell Surface Receptors;Cells;clinical database;clinical training;clinically relevant;collaborative environment;CRISPR/Cas technology;Data;design;Development;Dichloromethylene Diphosphonate;Disease;Ensure;Exhibits;experimental study;Foundations;Gene Expression;Gene Expression Profile;Genomics;Glioblastoma;Glioma;Goals;Grant;Heterogeneity;Human;improved;In Vitro;in vivo;in vivo evaluation;in vivo Model;innovation;Institution;Integrins;International;K-Series Research Career Programs;Knock-out;Ligands;Macrophage;Mediating;Mediator;Mentors;Mentorship;Mesenchymal;Michigan;Modeling;Molecular;multiple omics;neoplastic cell;neurosurgery;new therapeutic target;novel therapeutic intervention;novel therapeutics;Oncology;overexpression;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;Phenotype;Population;Primary Brain Neoplasms;Productivity;professor;programs;Proteins;Publishing;Radiation;radiation resistance;Recurrence;Recurrent tumor;Research;Research Ethics;Resistance;resistance mechanism;Role;Sampling;Scientist;Signal Transduction;single cell analysis;single-cell RNA sequencing;standard of care;stem;stem cell biomarkers;stem cell genes;stem cells;success;System;targeted treatment;temozolomide;Testing;therapy resistant;Training;Transcription Alteration;transcriptomics;tumor;Tumor Biology;tumor microenvironment;Universities;Up-Regulation;Work;Writing

PROJECT_TITLE: Defining Tumor Microenvironmental Interactions that drive THY1-Mediated Treatment Resistance in Glioblastoma

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ADMINISTERING_IC: HG

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Emergency Care;Genetic Testing;Genetics;Health Services;Human Genome;Patient Safety;Precision Medicine;Prevention

ORG_CITY: EVANSTON

ORG_NAME: ENDEAVOR HEALTH CLINICAL OPERATIONS

ORG_STATE: IL

PHR: PROJECT NARRATIVE The proposed project is relevant to public health because medication-related adverse events are a major cause of preventable hospital admissions, morbidity in the United States, and contribute substantially to health care costs. The proposed project will generate data that will inform our understanding of the contribution of gene-x-drug interactions (pharmacogenetics), in combination with multiple medical conditions and risk factors, to Emergency Department visits and hospital readmissions within 90 days of hospital discharge. The results from this project will advance knowledge on the impact of gene-x-drug reactions on adverse medical outcomes, and it will inform predictive models to better identify patients at the highest risk of hospital readmission attributable to adverse drug reactions. If patients at the highest risk of adverse drug reactions could be more accurately identified, we could better justify preemptive pharmacogenetic testing for the highest risk patients to prevent hospital admissions and better manage chronic health conditions.

PI_NAMEs: DAVID, SEAN P. (contact);MELTZER, DAVID O;O'DONNELL, PETER HUGH

PROGRAM_OFFICER_NAME: CHANG, CHRISTINE Q

PROJECT_TERMS: Accident and Emergency department;adjudication;Admission activity;adverse drug reaction;Adverse event;Affect;analytical method;Caring;Cessation of life;Characteristics;Chicago;Chronic;Clinical;clinically relevant;Cohort Studies;comorbidity;Complex;Computer software;Data;Data Set;Databases;design;Diagnosis;dosage;Dose;Drug Interactions;Drug Prescriptions;effectiveness clinical trial;Electronic Health Record;Emergency department visit;ethnic diversity;Event;experience;follow-up;Future;Genes;Genetic;genetic variant;genomic data;Genomic medicine;Genotype;genotyped patients;Goals;Guidelines;Health;Health Care Costs;Health system;Healthcare Systems;high risk;hospital readmission;Hospitalization;Hospitals;Individual;innovation;Inpatients;Intervention;Knowledge;Label;Learning;Length of Stay;Level of Evidence;Logistic Regressions;Measures;Medical;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;multidisciplinary;Natural Language Processing;novel;Outcome;Patient Admission;Patient Discharge;patient population;patient subsets;Patients;Pharmaceutical Preparations;pharmacogenetic testing;Pharmacogenetics;Pharmacogenomics;pharmacovigilance;predictive modeling;prevent;primary endpoint;programs;Protocols documentation;Public Health;Reaction;readmission rates;Research;Resources;response;Risk;Risk Factors;screening;side effect;Site;study population;Symptoms;Toxic effect;Treatment Failure;United States;United States Food and Drug Administration;Universities;Variant;Visit;World Health

PROJECT_TITLE: Integrative Analyses of Clinical Pharmacogenetic Data to Prevent Hospital Readmission in Real-World Health Systems

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-P (O1)]


FUNDING_MECHANISM: OTHERS

ORG_CITY: NORTH LITTLE ROCK

ORG_NAME: CENTRAL ARKANSAS VETERANS HLTHCARE SYS

ORG_STATE: AR

PHR: The overarching goal of my program is to understand how genetic and environmental factors interact to determine non communicable disease risk. For the past 15 years my VA supported research has characterized and validated a lipid signaling pathway as a unique determinant of heritable cardiovascular disease risk. To support these studies, we developed expertise in biomedical mass spectrometry which has become a major focus of my work. This latter issue is of great concern to veterans and active-duty military personnel as recently acknowledged by the Honoring our Promise to Address Comprehensive Toxics Act. I have set up an analytical laboratory that can measure multiple classes of environmental chemicals in small volumes of human biofluids. This laboratory is currently supporting population health studies of health effects of per and poly fluorinated substances using the Million Veteran Program and I am more broadly involved in efforts to enable routine biomonitoring of environmental exposures across the lifespan of Veterans and Service Members.

PI_NAMEs: MORRIS, ANDREW J (contact)

PROJECT_TERMS: active duty;Address;American Heart Association;analytical method;aortic valve disorder;Area;Arkansas;Atherosclerosis;Award;Biological Monitoring;Blood;Cardiovascular Diseases;cardiovascular disorder risk;career;Cells;Cellular Metabolic Process;Chemical Surfactants;Chemicals;cohort;Collaborations;Collection;Core Facility;data repository;Development;Diagnosis;Disease;disease registry;disorder risk;Dryness;Dyslipidemias;editorial;Endocrine;Endowment;Enrollment;Environment;environmental chemical;environmental chemical exposure;Environmental Exposure;Environmental Risk Factor;Epidemiologist;Equipment;Evaluation;Exposure to;Fingers;fire fighter;Funding;Funding Agency;General Population;Genes;Genetic;Goals;Government Agencies;Grant;Health;health determinants;Healthcare Systems;Heritability;Human;Immune System Diseases;Incidence;Individual;Institution;instrumentation;International;Journals;Kentucky;Laboratories;Leadership;life span;lipid metabolism;Lipids;Malignant Neoplasms;man;Mass Spectrum Analysis;Measurement;Measures;Medical;member;Metabolic Diseases;Military Personnel;minimally invasive;Modeling;Monitor;National Institute of Environmental Health Sciences;Nature;novel strategies;Paper;Pathology;peer;Phosphoric Monoester Hydrolases;Physicians;Poison;Poly-fluoroalkyl substances;population health;Population Study;Postdoctoral Fellow;pre-doctoral;Productivity;progenitor;Program Evaluation;programs;Publications;Recording of previous events;Reporting;Research;Research Peer Review;Research Personnel;Research Support;Resources;Risk;risk mitigation;Role;Science;Scientist;screening;Series;service member;Services;Signal Pathway;Signal Transduction;Spottings;structural biology;substance use;Superfund;symposium;Therapeutic;Time;Toxic Actions;Toxin;Training;United States National Academy of Sciences;United States National Institutes of Health;Universities;Validation;vascular inflammation;Veterans;Wages;Work

PROJECT_TITLE: BLRD Research Career Scientist Award Application

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 RCSR-N (01)]


ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

ORG_STATE: OH

PHR: Sepsis and acute respiratory distress syndrome (ARDS) are both life-threatening disorders that are prevalent in the Veteran population; the former caused by a dysregulated host immune response to infection and the latter a severe form of acute lung injury that may be non-infectious in etiology. In our animal models, neuro-inflammation develops in both conditions, and this alters ventilatory patterns. We propose to map changes in the respiratory network activity and brainstem neuro-inflammation due to septic and sterile injuries and test whether these changes can be reversed by central anti-inflammatory therapies.

PI_NAMEs: JACONO, FRANK JOSEPH (contact)

PROJECT_TERMS: 3-Dimensional;Acute Lung Injury;Affect;Anatomy;Animal Model;Anti-Inflammatory Agents;Atlases;Attenuated;awake;Biometry;Bleomycin;Blood;Brain;Brain Stem;Breathing;Cell Nucleus;Central Nervous System;clinical translation;Critical Care;cytokine;Cytokine Receptors;Data;Data Set;density;Disease;Disease Progression;Dorsal;Electrophysiology (science);Equilibrium;Escherichia coli;Etiology;Fluorescent in Situ Hybridization;Goals;Homeostasis;Immune response;Immunohistochemistry;improved;In Situ;Infection;Inflammation;Inflammation Mediators;Inflammatory;Injury;innovation;insight;Interleukin-1 beta;Interleukin-6;Intervention;Life;Lipopolysaccharides;Liver;Lung;lung injury;Magnetic Resonance Imaging;Maps;Measures;Mediating;Medicine;Microinjections;military veteran;Modeling;Molecular;Monitor;Motor;multi-electrode arrays;multimodal data;multimodality;Nerve;network dysfunction;neural network;neuroinflammation;Neurons;neuroregulation;new therapeutic target;Nucleus solitarius;Organ;Pathology;Patients;Pattern;Peripheral;Peritonitis;Pontine structure;Preparation;Process;Publishing;Rattus;Reaction;receptor;receptor expression;Reflex action;Regulation;Research Personnel;Respiration;Respiration Disorders;respiratory;response;RNA;Sensory;sensory feedback;Sepsis;sepsis induced ARDS;septic;Severity of illness;Site;Sleep;Sprague-Dawley Rats;Sterility;Stimulus;Synapses;Systemic infection;targeted treatment;Technology;Testing;tocilizumab;ventilation

PROJECT_TITLE: Neuroinflammation disrupts cardio-respiratory circuits and patterns

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 NURB-H (01)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: Project Narrative  Alzheimer’s disease becomes a leading cause of the death for aged people in developed countries, and understanding the progression of Alzheimer’s disease is crucial for finding the cure for this disease. In this project, we will determine how a transmembrane protein called CD151 regulates the progression of Alzheimer’s disease. Our study will also provide insight into the general mechanisms that govern the brain inflammation and identify promising candidates to combat degenerative diseases and chronic inflammation of brain.

PI_NAMEs: RICE, HEATHER C. (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: abeta accumulation;abeta deposition;Ablation;Aging;aging population;alpha secretase;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Amyloid beta-Protein;amyloid precursor protein processing;Astrocytes;behavior change;beta secretase;Biology;Blood Vessels;Brain;brain endothelial cell;C-terminal;Cause of Death;Cell Adhesion;Cell membrane;Cell model;cell motility;cell type;Cells;Chronic;Clinical;combat;Cultured Cells;Cysteine;Cytoplasm;Cytosol;Degenerative Disorder;Deposition;Developed Countries;Development;differential expression;Disease;disease phenotype;Disease Progression;Encephalitis;Excision;exosome;extracellular;familial Alzheimer disease;Family;Functional disorder;gamma secretase;Genetic;glycosylation;Goals;In Vitro;in vivo;Inflammation;Inflammatory;insight;Integral Membrane Protein;Integrins;Iowa;Knock-in Mouse;Knock-out;Knockout Mice;Life;Link;Measures;member;Membrane;Membrane Microdomains;Memory;Metabolism;Microglia;Molecular;mouse model;Mus;mutant;Mutation;neuroinflammation;Neuronal Dysfunction;Neurons;novel;novel strategies;palmitoylation;Pathogenesis;Pathogenicity;Pathologic;Pathology;Peptide Hydrolases;Phenotype;Plasma;Primary Cell Cultures;Process;promoter;protein degradation;Proteins;Proteolysis;Proteolytic Processing;Regulation;Research Project Grants;restraint;Role;secretase;Senile Plaques;Signaling Molecule;Sorting;Stimulus;Structure;Swedish mutation;Testing;TG gene;therapeutic development;trafficking;Transgenic Organisms;Transmembrane Domain;treatment strategy

PROJECT_TITLE: The role of tetraspanin-regulated endolysosomal trafficking in Alzheimer's Disease

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_NAME: BOSTON MEDICAL CENTER

PHR: PROJECT NARRATIVE Hypertensive disorders of pregnancy (HDPs) present a unique opportunity to improve the health of reproductive-age individuals with elevated cardiovascular disease risks. However, key evidence gaps have limited interventions. Through the proposed K23 research, I will advance our understanding of cardiovascular health (distribution and determinants) after HDPs; pilot test a novel intervention to improve cardiovascular health after HDPs; and develop the skills to become an independent investigator who can develop and disseminate effective, equity-focused interventions.

PI_NAMEs: MURRAY HORWITZ, MARA EVE (contact)

PROGRAM_OFFICER_NAME: SIDDIQUI, AYESHA SAEED

PROJECT_TERMS: acceptability and feasibility;Address;Affect;Age;Ambulatory Care;Area;Award;Black race;black women;Blood Pressure;blood pressure control;Boston;Cardiac health;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;career;Caring;Clinical Trials Design;community engagement;Competence;Complex;Consolidated Framework for Implementation Research;Data;Data Set;Dedications;Drops;effectiveness testing;effectiveness trial;Electronic Health Record;Ensure;Epidemiology;Equity;Evidence based intervention;experience;feasibility testing;follow-up;Funding Opportunities;Future;Goals;Health;health care availability;health care service organization;health care settings;health equity;health inequalities;Health Services;Health system;Healthcare;High Prevalence;Hospitals;housing instability;Hypertension;hypertensive;implementation barriers;implementation facilitators;implementation framework;implementation strategy;improved;Income;Individual;Insurance;Intervention;intervention effect;Justice;Knowledge;Learning;Life;Life Cycle Stages;Link;Low income;Maps;Measures;Medical center;Mentors;Methods;Modeling;multilevel analysis;National Heart, Lung, and Blood Institute;Neighborhood Health Center;New England;novel;Outcome;Pathway interactions;patient navigation;Patients;Persons;pilot test;pilot trial;Population;Population Distributions;Population Heterogeneity;postpartum care;Postpartum Period;Pragmatic clinical trial;predictive modeling;Pregnancy;pregnancy disorder;Prevalence;Preventive care;Process;Qualifying;Qualitative Methods;Qualitative Research;racial disparity;Randomized;Randomized, Controlled Trials;Recommendation;Reduce health disparities;Reproductive Health;Research;Research Methodology;Research Personnel;response;Risk;Risk Assessment;Risk Factors;risk prediction;safety net;Sampling;Science;screening;Site;skills;social;social factors;Specificity;standard care;Strategic vision;structural determinants;Techniques;Training;United States;United States National Institutes of Health;Variant;Woman;Work;World Health

PROJECT_TITLE: From Hypertensive Pregnancy to Heart Health: Understanding and Addressing Multi-Level Barriers to Cardiovascular Health after Hypertensive Disorders of Pregnancy

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (OA)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Globally, 3 million people die from excess salt as the leading dietary risk factor for CVD each year and this is a significant public health problem that must be addressed. The U.S. is one of the top three countries with highest population sodium intake per day and one of top four countries with the largest CVD burden; however, there are not much data regarding which sodium reduction policy ‘has been’ adopted, what ‘might be’ the health gain and its distribution in nationwide policy implementation, and what ‘could be’ implemented in the multi-level system in the U.S. The proposed research is innovative in applying RE-AIM to policy implementation science and developing an interactive tool that can be used in the future as part of a strategy to improve policy implementation to ultimately eliminate preventable cardiovascular health disparities.

PI_NAMEs: SU, YANFANG  (contact)

PROGRAM_OFFICER_NAME: SMITH, SHARON M

PROJECT_TERMS: Acceleration;Accounting;Address;Adopted;Adoption;Adult;Age;American;Area;Award;Awareness;Black race;burden of illness;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Categories;Cessation of life;Child;cohort;Consumption;cost;Country;County;Data;Data Analyses;Data Sources;Dedications;dietary;Dimensions;disease model;Equity;Excess Dietary Salt;Feasibility Studies;food preparation;Formulation;Foundations;Funding;Future;Goals;Health;health disparity;health equity;Hospitals;Household;implementation science;improved;Income;innovation;Institution;Intake;interactive tool;Interview;Label;Language;Learning;Low income;Maintenance;mathematical model;Measures;men;Mentors;Mentorship;Methods;milligram;Modeling;mortality;multidisciplinary;National Heart, Lung, and Blood Institute;Not Hispanic or Latino;novel;Nursing Homes;Outcome Study;Persons;Policies;Policy Maker;Population;post-doctoral training;public education;Public Health;Race;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;Role;Schools;Science;Scientist;sex;simulation;Sodium;System;Target Populations;tool;Training;Translations;United States;United States Food and Drug Administration;Universities;Visualization;Washington;Woman;Workplace;World Health Organization

PROJECT_TITLE: Population strategies to reduce sodium intake and cardiovascular diseases in the United States: Applying RE-AIM to policy implementation

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (OA)]


ORG_CITY: TAMPA

ORG_NAME: JAMES A. HALEY VA MEDICAL CENTER

ORG_STATE: FL

PHR: The apolipoprotein E (APOE) E4 allele represents a major genetic risk factor for Alzheimer’s disease (AD) that is known to cause brain blood vessel damage, compromise the transport of glucose to nerve cells for generating energy, and impair toxic Abeta waste removal from the brain. This proposed work will evaluate and identify ways to regulate the usage of fats as a source of energy in brain blood vessel cells, thereby improving the transportation of nutrients within the brain and supporting the energy needs of astroglia and neurons. Correcting fat utilization in the blood vessels will also restore the astroglia’s ability to remove toxic Abeta from the brain. Ultimately, this will lead to the development of therapeutic interventions for E4 carriers who have an increased risk of developing AD.

PI_NAMEs: ABDULLAH, LAILA  (contact)

PROJECT_TERMS: Abeta clearance;Acetyl-CoA Carboxylase;acylcarnitine;Age;age effect;age related;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer's disease therapy;Amyloid;Amyloid beta-Protein;Animals;Apolipoprotein E;apolipoprotein E-4;aquaporin 4;Astrocytes;Bioenergetics;Blood - brain barrier anatomy;Blood Vessels;Brain;brain endothelial cell;brain parenchyma;burden of illness;Cells;cerebrovascular;Cerebrovascular Disorders;cerebrovascular pathology;Cerebrovascular system;Chemicals;cognitive function;Couples;Cre lox recombination system;Detection;Deterioration;Early Intervention;Energy-Generating Resources;Environment;Enzymes;Equilibrium;Excision;experience;Failure;Fatty acid glycerol esters;fatty acid metabolism;fatty acid oxidation;fatty acid transport;Fatty Acids;flexibility;Genes;Genetic;genetic risk factor;Genotype;Glucose;glucose metabolism;glucose transport;glucose uptake;Glycolysis;glymphatic clearance;glymphatic function;Hemorrhage;Human;Impairment;improved;Individual;Inflammation;inhibitor;insight;Ketones;knock-down;Knock-out;knockout gene;Levocarnitine;Link;lipidomics;long chain fatty acid;Mediating;Metabolism;metabolomics;Mission;Mitochondria;Molecular;mouse model;Mus;Neurons;neurovascular unit;novel;novel therapeutics;Nutrient;oxidation;Oxidative Stress;Pathogenesis;Pathology;Pathway interactions;Persons;pre-clinical;Process;Property;Reporting;Research;Risk;Stable Isotope Labeling;System;tau Proteins;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutic target;Time;transcriptomics;Transportation;Waste Products;wasting;Work;β-amyloid burden

PROJECT_TITLE: the contribution of APOE4 mediated bioenergetic deficits in the cerebrovascular dysfunction in Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 NURD-E (01)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Pain Research;Patient Safety;Women's Health Research

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE Female patients have been excluded from prior clinical trials evaluating groin hernia management, which may result in worse outcomes among females following surgery (e.g., higher rates of recurrent hernia, worse pain) compared to males. This Career Development Award will provide the candidate with the necessary training as well as establish the infrastructure and critical foundational data to conduct the first ever patient-centered clinical trial for females with groin hernia. This work will inform the development of evidence-based guidelines and training to improve care for tens of thousands of females with groin hernia.

PI_NAMEs: EHLERS, ANNE PUGEL (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: acceptability and feasibility;Activities of Daily Living;Address;Board Certification;career;career development;Caring;Characteristics;Chronic;Clinical;Clinical Trials;Clinical Trials Design;Data;Data Analyses;design;Development;Disparity;education planning;Enrollment;EuroQOL;Evaluation;evidence based guidelines;Exclusion;Female;follow-up;Future;Goals;Guidelines;Health Services;Hernia;improved;Inferior;Infrastructure;Inguinal region;innovation;interest;Interview;K-Series Research Career Programs;male;Measures;Mentorship;Methodology;Michigan;Multi-Institutional Clinical Trial;multidisciplinary;novel;Operative Surgical Procedures;Outcome;Pain;Pain intensity;Pain interference;Patient Compliance;patient engagement;Patient observation;patient oriented;Patient Outcomes Assessments;Patient Recruitments;patient retention;Patients;Pilot Projects;Population;population based;Population-Based Registry;Positioning Attribute;Postoperative Pain;Postoperative Period;preference;primary outcome;Procedures;Protocols documentation;Quality of life;Randomized;Recommendation;recruit;Recurrence;Registries;repaired;Research;Research Personnel;Research Priority;Research Proposals;Risk;Sample Size;satisfaction;Scientist;sex as a biological variable;Site;skills;Structure;Surgeon;Surveys;Symptoms;Techniques;Testing;Training;treatment as usual;women patients;women's clinical trial;women's outcomes;Women's study;Work

PROJECT_TITLE: Sex as a Biologic Variable in Groin Hernia

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative  Alzheimer's disease is one of the most common and progressive genetic neurodegenerative disorders in the US with more than 5 million people currently living with Alzheimer's disease with risk factors often associated with age and sex. Women are more likely to develop a rapid progression of Alzheimer's disease, than men when predictive factors such as obesity, lifespan, and enhanced stroke severity are considered. We describe protein arginine methyltransferase 4 modulation as a therapeutic potential against Alzheimer's disease and other vascular cognitive impairment disorders.

PI_NAMEs: LIN, HUNG WEN (KEVIN)  (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: 3xTg-AD mouse;abeta accumulation;Age;age related;aged;Alternative Therapies;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease related dementia;Area;Attenuated;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier disruption;blood-brain barrier permeabilization;Brain;brain metabolism;Cell Adhesion Molecules;Cell Nucleus;Cerebrovascular Circulation;Cerebrovascular Disorders;Circulation;Cognition;Coupled;Cytoplasm;Data;Deterioration;Development;Diameter;discrimination task;Disease;Disease Progression;Embryo;Enzymes;Extravasation;Family;Female;functional outcomes;gender difference;Genetic;Goals;Human;Immunity;Impairment;Inflammation;inhibitor;innovation;Investigation;knock-down;Knockout Mice;Knowledge;Laser Scanning Microscopy;Laser Speckle Imaging;Learning;Leucocytic infiltrate;Leukocyte Rolling;life span;male;Malignant Neoplasms;Measures;Mediating;Memory;Memory impairment;men;Messenger RNA;Methylation;Modality;Mus;Nervous System Disorder;Neurodegenerative Disorders;Neurofibrillary Tangles;Neurons;neurovascular;neurovascular coupling;NOTCH1 gene;novel;Obesity;object recognition;occludin;Pathway interactions;Patients;Persons;Post-Translational Protein Processing;Predictive Factor;preservation;Process;protein expression;Protein Inhibition;Protein-Arginine N-Methyltransferase;Proteins;Regulatory Element;response;Risk Factors;Role;senescence;Severities;sex;Sex Differences;Signal Transduction;Stroke;System;tau aggregation;tau Proteins;Texture;Therapeutic;Tight Junctions;two-photon;Vascular Cognitive Impairment;Vibrissae;Woman

PROJECT_TITLE: Protein Arginine Methyltransferases in Alzheimer's disease

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Hematology;Human Genome;Immunotherapy;Lymphatic Research;Lymphoma;Precision Medicine;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE A substantial subset of follicular lymphoma (FL) patients has an early relapse and a poor clinical outcome; however, little is known of the molecular mechanisms responsible for these aggressive features. We have demonstrated that the tumor microenvironment (TME) plays a key role in treatment failure and found that FLs with increased expression of IRF4 have dysregulated immune signaling, a suppressive TME, and a poor prognosis. In this project, we aim to elucidate the mechanisms by which IRF4 controls tumor immunity and define the concordant immunophenotypic changes, ultimately paving the way for novel precision therapies for this unfavorable patient population.

PI_NAMEs: MONDELLO, PATRIZIA  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Advisory Committees;Affect;Antigen Presentation;B cell differentiation;B-Cell Lymphomas;B-Lymphocytes;Biological;career;Cell Count;Cell Physiology;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;Chromatin Remodeling Factor;Clinic;Clinical;clinical practice;cytokine;Cytometry;Data;Ecosystem;Educational Curriculum;effective therapy;Environment;Epigenetic Process;Equilibrium;experience;Flow Cytometry;Follicular Lymphoma;Funding;Genetic;Genetic Transcription;Goals;Helper-Inducer T-Lymphocyte;high dimensionality;Human;human data;Immune;Immune Evasion;Immune signaling;Immunologic Receptors;immunological synapse;Immunophenotyping;Immunotherapy;improved;Indolent;Infiltration;insight;Interleukin-10;IRF4 gene;knowledge base;Laboratories;Lead;Leadership;Link;Lymphoma;Lymphomagenesis;Malignant - descriptor;Mentorship;Modeling;Molecular;mouse model;Mutation;nano-string;NF-kappa B;novel;Outcome;overexpression;patient population;Patients;Phenotype;Play;precision medicine;Precision therapeutics;Predictive Factor;prevent;Prognosis;prognostic;programmed cell death ligand 1;programs;Proteomics;Relapse;Research Personnel;response;Risk;Role;Sampling;Scientist;Secondary to;Shapes;Signal Transduction;Signaling Molecule;skills;Structure;Structure of germinal center of lymph node;survival prediction;T-Lymphocyte;Testing;Therapeutic;therapeutic target;TNFRSF5 gene;tool;transcription factor;transcriptome sequencing;transcriptomics;Transgenic Mice;translational cancer research;translational research program;Treatment Failure;tumor;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;Tumor-infiltrating immune cells;Universities

PROJECT_TITLE: Elucidating the role of IRF4 in reprogramming the tumor microenvironment in follicular lymphoma

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Immunotherapy

ORG_CITY: BOCA RATON

ORG_DEPT: CHEMISTRY

ORG_NAME: FLORIDA ATLANTIC UNIVERSITY

PHR: PROJECT NARRATIVE The main goal of our research is to prepare novel synthetic tools to explore interactions between various MUC1 glycopeptide models, including glycopeptide libraries, with lectins involved in cancer immune evasion. These studies will elucidate further the mechanism by which tumor-associated glycans contribute to the observed immunomodulatory actions by tumors and enable the development of novel and more effective anti- cancer immunotherapeutic strategies.

PI_NAMEs: CUDIC, MARE  (contact)

PROGRAM_OFFICER_NAME: COUCH, JENNIFER A

PROJECT_TERMS: Affinity;anti-cancer;anti-tumor immune response;Antibodies;antigen binding;Antigen Presentation;Antigens;Atomic Force Microscopy;atomic interactions;B-Lymphocytes;Binding;Biological Assay;Biology;Biotinylation;Calorimetry;cancer immunotherapeutics;cancer immunotherapy;Cancer Patient;cancer site;cancer stem cell;carbohydrate binding protein;carbohydrate receptor;Carbohydrates;Carcinoma;Cell Separation;Cell surface;Cells;Chemistry;Collaborations;combinatorial;Compensation;Complex;density;design;Development;enthalpy;Entropy;Enzyme-Linked Immunosorbent Assay;Epitopes;Funding;Galactose;Germany;Glycobiology;Glycopeptides;Glycoproteins;Glycosides;glycosylation;Goals;graduate student;Grant;Heterogeneity;Human;Hydration status;Immune;immune checkpoint;Immune response;Immune system;Immunology;immunoregulation;improved;insight;interest;Journals;Kinetics;Knowledge;Lectin;Lectin Receptors;Letters;Libraries;Ligands;Macrophage;Measurement;Modeling;Molecular;Monoclonal Antibodies;Mucin 1 protein;Mucins;neoantigens;Neoplasm Metastasis;next generation;novel;Patients;Pattern;Peptides;Polysaccharides;Positioning Attribute;Primary Neoplasm;Progress Reports;Proteins;Publications;receptor;recruit;Research;Role;S phase;Scaffolding Protein;Scanning;Scheme;Scientist;screening;sialic acid binding Ig-like lectin;sialylation;Signal Transduction;Solid;Specificity;Tandem Repeat Sequences;Testing;Thermodynamics;Thompson-Friedenreich Antigen;Time;Titrations;tool;Translating;trend;tumor;Tumor Antigens;Tumor Escape;tumor microenvironment;tumor progression;Tumor-Associated Carbohydrate Antigens;tumorigenic;undergraduate research experience;undergraduate student;Universities;Vertebral column;Water

PROJECT_TITLE: Mechanistic insight into tumor-associated MUC1 glycopeptides binding to macrophage galactose-type lectin

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Anxiety Disorders;Brain Disorders;Cardiovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Mental Health;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative U.S. veterans are an increasingly racially/ethnically and geographically diverse population that may be at increased risk of Alzheimer's Disease and Related Dementias (ADRD) due to their high prevalence of cardiovascular risk factors such as hypertension and heightened exposure to ADRD risk factors such as traumatic brain injury, posttraumatic stress disorder and depression (military-related exposures). The relationships between hypertension, blood pressure targets, and ADRD risk within potential high-risk subgroups are not well understood, but an integrated nationwide healthcare system like the Veterans Health Administration (VHA) provides a unique opportunity to rigorously examine these relationships in a large, national, and increasingly diverse population. In this study, we leverage VHA data to estimate the association of hypertension and ADRD risk, assess how military-related exposures influence this relationship, and estimate hypertension treatment effects at various treatment targets for optimized reduction in ADRD burden.

PI_NAMEs: CALONICO, NESTOR SEBASTIAN;YAFFE, KRISTINE  (contact);ZEKI AL HAZZOURI, ADINA

PROGRAM_OFFICER_NAME: PERCY-LAURRY, ANTOINETTE LOIS

PROJECT_TERMS: Adult;Age;Alaska Native;Alzheimer's disease related dementia;Alzheimer's disease risk;American Indians;Anti-Hypertensive Agents;Area;Asian;Black race;Blood Pressure;Blood Vessels;cardiovascular disorder risk;cardiovascular risk factor;Characteristics;cohort;Data;data integration;Data Set;Databases;Dementia;dementia burden;dementia risk;deprivation;design;Disadvantaged;Disparity;econometrics;Electronic Health Record;ethnic difference;ethnic disparity;ethnic diversity;Ethnic Origin;Ethnic Population;Exposure to;Foundations;General Population;geographic difference;geographic disparity;Geographic Locations;Geography;Goals;Healthcare;Healthcare Systems;High Prevalence;high risk;high risk population;human old age (65+);Hypertension;hypertension treatment;improved;Incidence;indexing;innovation;Investigation;Latinx;member;Mental Depression;Methods;Military Personnel;military service;Minority Groups;modifiable risk;Neighborhoods;novel;older adult;Population;Population Heterogeneity;Post-Traumatic Stress Disorders;Prevalence;Prevention;Prevention strategy;Provider;psychosocial;Public Health;Race;racial difference;racial disparity;racial population;repository;Research;Risk Factors;Risk Reduction;Sampling;Single-Payer System;Statistical Methods;stem;Subgroup;Traumatic Brain Injury;treatment effect;treatment guidelines;Underrepresented Minority;vascular risk factor;Veterans;Veterans Health Administration;Woman

PROJECT_TITLE: Hypertension, Blood Pressure Targets, and Alzheimer’s Disease and Dementia Risk and Disparities among Nationally Representative US Veterans

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Palliative Care;Rare Diseases;Social Determinants of Health

PHR: Project Narrative Patients with malignant primary central nervous system (CNS) tumors experience significant distress about their diagnosis, poor prognosis, and expected neurological decline, often leading to avoidant coping behavior that negatively impacts their mood and quality of life. The proposed research project aims to refine and pilot test a psychosocial intervention designed to alleviate distress, facilitate coping and promote values-driven behavior in patients with newly diagnosed malignant primary CNS tumors. Study findings will drive future research in this understudied area and inform development and delivery of interventions to support patients with malignant primary CNS tumors, with potential application to patients with a wide range of neurological illnesses and cancer.

PI_NAMEs: FORST, DEBORAH A (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: absorption;Address;Advanced Malignant Neoplasm;Adverse effects;Advisory Committees;aggressive therapy;American;Area;Award;Behavior;Behavioral;behavioral outcome;Biometry;career;career development;Caregivers;Central Nervous System;Central Nervous System Neoplasms;Chemotherapy and/or radiation;Clinical;Clinical Investigator;Cognitive;Cognitive deficits;Communication;Communication Barriers;Communication difficulty;coping;Coping Behavior;Coping Skills;Data;Decision Making;Depressed mood;design;Deterioration;Development;Diagnosis;Disease;Distress;Educational workshop;efficacy testing;Elements;Eligibility Determination;Enrollment;evidence base;experience;Face;Family;Feasibility Studies;Feedback;Feeling;Five-Year Plans;Friends;Funding;Glioblastoma;Goals;Impaired cognition;improved;improved outcome;information processing;Intervention;intervention delivery;intervention effect;intervention refinement;Interview;Knowledge;Life;Life Expectancy;Linguistics;loved ones;Malignant - descriptor;Malignant neoplasm of central nervous system;Malignant Neoplasms;Mentors;Mentorship;mindfulness;Modality;Moods;Nervous System;neuro-oncology;Neurologic;Neurologic Deficit;Neurologic Dysfunctions;Neurological status;Newly Diagnosed;novel;Oncologist;Operative Surgical Procedures;Outcome;Participant;Patient Care;patient engagement;Patient-Focused Outcomes;Patients;Personality;Physicians;Pilot Projects;pilot test;Population;Population Intervention;prevent;primary outcome;Prognosis;prognostic;Protocols documentation;psychologic;psychological distress;psychological outcomes;psychosocial;Public Health Schools;Quality of life;Randomized, Controlled Trials;Rehabilitation therapy;Reporting;Research;Research Personnel;Research Project Grants;skills;Social isolation;stressor;Structure;Supportive care;symposium;Symptom Burden;Symptoms;Techniques;Terminal Disease;Testing;therapy design;Thinking;Training;treatment as usual;Treatment Efficacy;tumor;Work

PROJECT_TITLE: An Acceptance and Commitment Therapy-Based Psychosocial Intervention to Alleviate Distress and Promote Adaptive Coping Skills in Patients with Malignant Primary Central Nervous System Tumors


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Prevention

ORG_CITY: MINNEAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PROJECT NARRATIVE Atrial myopathy is a novel biomarker for cardiovascular disease (CVD) risk that can be detected by measuring left atrial function before left atrial enlargement occurs, offering a potential opportunity to identify and treat high risk individuals before clinically symptomatic CVD occurs. We propose to randomize 80 individuals without diabetes and at risk for heart failure to either empagliflozin or placebo and conduct assessments of left atrial and left ventricular function and change in plasma proteins after 9 months of intervention. Results from this trail will provide novel preliminary evidence about the hypothesized effect of empagliflozin on left atrial and left ventricular function in an understudied population and inform a larger R01-funded RCT evaluating the effect on clinical outcomes in this population.

PI_NAMEs: VAN'T HOF, JEREMY R. (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Adult;Atrial Fibrillation;Board Certification;Cardiac;Cardiac Myocytes;Cardiology;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;Cardiovascular system;career;career development;Clinic;Clinical;Clinical Skills;Clinical Trials;Clinical Trials Design;Data;Dementia;design;Detection;Development;Development Plans;Diabetes Mellitus;Diagnosis;Disease Outcome;Double-Blind Method;Early Diagnosis;Echocardiography;Education;Enrollment;Evaluation;Event;experience;Functional disorder;Funding;Future;Glucose;Goals;Grant;Heart Atrium;Heart failure;high risk population;Hospitalization;Hypertension;Image;improved;Individual;Inflammation;Inflammatory;inhibitor;Intervention;Ischemia;K-Series Research Career Programs;ketogenesis;Knowledge;Lead;Leadership;Left;Left Atrial Function;Left atrial structure;Left Ventricular Function;Left Ventricular Mass;Left Ventricular Remodeling;Left ventricular structure;lipid metabolism;Measures;Mediating;meetings;Mentors;Metabolic;Minnesota;Morbidity - disease rate;mortality;multidisciplinary;Myopathy;new therapeutic target;novel;novel marker;Obesity;older adult;oral communication;Outcome;Pathway interactions;patient oriented research;patient screening;Patients;Pharmaceutical Preparations;Phase;Physicians;Pilot Projects;Placebo Control;placebo group;Placebos;Plasma Proteins;Population;pressure;prevent;Preventive;Preventive therapy;primary endpoint;Protein Analysis;Proteins;Proteomics;Randomized;Relaxation;Research;Research Personnel;Risk;Risk Factors;Risk Reduction;Running;Scientist;skills;Sodium;Stroke;Structure;symporter;Testing;Training;treatment duration;treatment effect;two-dimensional;Universities;Ventricular;Visit;Work;Writing

PROJECT_TITLE: Effects of Empagliflozin on Left Atrial Function in Adults at Risk for Heart Failure


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Lung;Microbiome;Nutrition;Pulmonary Hypertension;Rare Diseases

PHR: Project Narrative This proposal is designed to further train Sasha Prisco, MD, PhD in molecular and cellular cardiac physiology and multiple omics techniques to help in the transition to becoming an independently funded physician-scientist who studies the mechanisms of right ventricular dysfunction in pulmonary hypertension. Her project investigates if Lactobacillus supplementation modulates the gut microbiome, systemic inflammation, the microtubule cytoskeleton, and right ventricular function in pulmonary arterial hypertension. During her training, she will refine skills that will enable her to perform clinically-relevant, translational research that will hopefully allow for future development of novel therapies for this rare and devastating disease.

PI_NAMEs: PRISCO, SASHA ZHENG (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Address;Adverse effects;Affect;alpha Tubulin;Attenuated;B-Lymphocytes;Bacterial Translocation;beta Tubulin;Cardiac;Cardiac Myocytes;Cardiovascular system;career;Cells;Cessation of life;clinically relevant;cytokine;Cytokine Activation;Cytokine Receptors;Cytoskeleton;Data;Depressed mood;design;Development;dietary;Disease;Doctor of Philosophy;Down-Regulation;Echocardiography;Exercise Test;experimental study;Family;Fibrosis;Funding;Future;glycoprotein 130;Goals;Goblet Cells;gut dysbiosis;gut microbiome;gut microbiota;hemodynamics;Histologic;Hypertrophy;Hypoxia;Immune;immune activation;Immunofluorescence Immunologic;improved;in vivo;Inflammation;Intermittent fasting;intestinal barrier;Intestinal permeability;intestinal villi;Intestines;jejunum;junctophilin;Knowledge;Lactobacillus;Left Ventricular Dysfunction;Length;Lung;Macrophage;Measures;Mediating;Mentors;Metagenomics;microbiome;microbiome analysis;Microtubules;Modeling;Molecular;Monocrotaline;Morphology;mortality;Mucins;multiple omics;Myocardial Infarction;novel;novel therapeutic intervention;novel therapeutics;Pathologic;pharmacologic;Physicians;Physiologic intraventricular pressure;Physiology;pre-clinical;prevent;Proliferating;Proteins;Proteomics;pulmonary arterial hypertension;Pulmonary Hypertension;Rattus;Receptor Activation;Research;Right Ventricular Dysfunction;right ventricular failure;Right Ventricular Function;Right ventricular structure;Rodent Model;Scientist;Serum;Serum Proteins;Signal Transduction;single-cell RNA sequencing;skills;Structure;Supplementation;survival prediction;systemic inflammatory response;T-Lymphocyte;Techniques;Testing;Time;Training;Translational Research;treadmill;Vascular Diseases;Ventricular;Villus

PROJECT_TITLE: Modulating the Microbiome to Enhance Right Ventricular Function in Pulmonary Arterial Hypertension


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE This study contributes significantly to public health by providing evidence about nurse practitioner (NP) teams in primary care practices caring for persons living with dementia. The evidence produced will help to design future dementia-capable primary care NP teams. Strengthening NPs teams will help to improve dementia care and eliminate persistent racial and ethnic health disparities.

PI_NAMEs: POGHOSYAN, LUSINE  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: Accident and Emergency department;Address;Adult;Advocate;Affect;Age;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;American;Black race;care delivery;Care given by nurses;care systems;Caring;Characteristics;Collaborations;Communication;Competence;Complex;Conflict (Psychology);Creativeness;Data;Delphi Technique;Dementia;dementia care;design;Discipline;Disparity;Effectiveness;Emergency department visit;ethnic disparity;ethnic health disparity;ethnic minority;Exercise;experience;Future;Goals;health disparity;health equity;Health Policy;Hispanic;Hospital Departments;Hospitalization;hospitalization rates;human old age (65+);improved;innovation;interest;Intervention;Interview;Lead;Maps;Medicare claim;member;Methodology;Methods;Modeling;novel;Nurse Practitioners;Nurses;Nursing Assessment;older adult;Outcome;outcome disparities;Pathway Analysis;Patient Care Team;Patient-Focused Outcomes;Patients;Persons;Physicians;Policies;Policy Maker;policy recommendation;Population;Primary Care;Primary Care Physician;primary care practice;Primary Nursing Care;Problem Solving;Productivity;Psychologist;Public Health;Quality of Care;racial disparity;racial health disparity;racial minority;Recommendation;Research;response;Sampling;Science;Service delivery model;skills;Social Network;Social Workers;success;Surveys;System;team-based care;Trust;Work

PROJECT_TITLE: Social Networks in Nurse Practitioner Teams Caring for Patients with Dementia and Impact on Racial and Ethnic Disparities

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Infectious Diseases

ORG_CITY: IOWA CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Mold infections are a significant cause of morbidity and mortality worldwide, and are among the hardest-to- treat fungal infections due to limited efficacy of current antifungal drugs. There is an urgent need for antifungals to treat these infections and in this proposal, we aim to meet that need by performing a high throughput antifungal drug screen directly with the mold Aspergillus fumigatus. The goal of this work is to identify mold- active antifungal scaffolds with novel mechanisms of action for preclinical development to fight life-threatening mold infections.

PI_NAMEs: BEATTIE, SARAH R. (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Address;adenylate kinase;Affect;anti-fungal agents;Aspergillus fumigatus;Biological Assay;Biomass;Blindness;Candida albicans;candidate identification;Cell Line;Cells;chemical genetics;Chemicals;chemotherapy;Clinical;cohort;Cornea;Cytolysis;Death Rate;density;design;Development;Devices;Disease;Disease Outcome;drug development;drug discovery;Drug resistance;Drug Screening;drug-like compound;Enzymes;falls;fighting;Filament;Funding Opportunities;Fungal Drug Resistance;Future;Generations;Genetic Screening;Germination;Goals;Growth;Hematopoietic;high throughput screening;Human;Immune;In Vitro;Individual;Infection;Iowa;Keratitis;Kinetics;Libraries;Life;Liquid substance;Luciferases;Mammalian Cell;Measurement;Measures;Medical;Molds;Morbidity - disease rate;mortality;mutant;Mycoses;Neurofibrillary Tangles;novel;Operative Surgical Procedures;Optics;organ transplant recipient;Organism;Pathway interactions;patient population;Patients;preclinical development;Predisposition;Resistance;scaffold;screening;Severity of illness;small molecule libraries;Solid;Steroids;Testing;Therapeutic Index;Toxic effect;Universities;Work;Yeasts

PROJECT_TITLE: HTS with Aspergillus fumigatus for novel, mold-active antifungals

STUDY_SECTION: DMPA

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology A Study Section [DMPA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Hematology;Infectious Diseases;Neurodegenerative;Neurosciences;Prevention;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Understanding how persistent,pathogenic exosomes promote cerebrovascular disease during and after zoster, thereby accelerating vascular dementia risk, is significant because it will potentially change clinical practice with regards to duration of antiviral therapy and use of anti-platelet agents for zoster, as well as increase support for vaccination to prevent rash and stroke, as well as to decrease vascular dementia risk. Furthermore, our findings will serve as a model for how other pathogens can have long-lasting effects at sites remote from regions of infection and stimulate further research on the biological consequences of pathogen- associated exosomes and potential therapeutics, including agents that block exosome release and fusion.

PI_NAMEs: BUBAK, ANDREW N (contact)

PROJECT_TERMS: Acceleration;Activated Partial Thromboplastin Time measurement;Acute;Adhesions;Age Years;Aging;American;Amyloid;Anti-viral Agents;Anti-viral Therapy;Antiplatelet Drugs;apolipoprotein E-4;biobank;Bioinformatics;Biological;Biological Assay;Biology;Blood flow;Blood Platelets;Blood Vessels;Brain hemorrhage;Brain region;Calmodulin 1;Caveolae;Cells;cerebral artery;Cerebral Thrombosis;cerebrovascular;Cerebrovascular Disorders;Clinic Visits;Clinical;clinical center;clinical practice;Clinical Research;Clot retraction;Complete Blood Count;cytokine;Data;Dementia;dementia risk;Development;Diabetes Mellitus;Diameter;Disease;Distal;DNA Viruses;Ensure;Environmental Risk Factor;epidemiology study;Event;Exanthema;exosome;experimental study;extracellular vesicles;Factor V;Fibroblasts;Flow Cytometry;Generations;Herpes zoster disease;Herpesvirus Type 3;Human;Hyperlipidemia;Hypertension;IL8 gene;Immunoglobulin G;Immunoglobulin M;Impaired cognition;Individual;Infection;Inflammation;Inflammatory;Integration Host Factors;Interferon Type II;Interleukin-1 beta;Interleukin-10;Interleukin-13;Interleukin-2;Interleukin-4;Interleukin-6;Ischemic Stroke;knock-down;Laboratories;Leukocytes;Mass Spectrum Analysis;Mediating;Metabolic;Microfluidics;MicroRNAs;Modeling;modifiable risk;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neurology;neurotropic;P-Selectin;pathogen;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Phosphatidylserines;Plasma;Platelet Activation;platelet function;Prealbumin;prevent;Process;Proteins;Reactive Oxygen Species;Research;Research Personnel;Risk;Risk Factors;Risk Reduction;risk variant;Sampling;Site;Small RNA;Stroke;Testing;Therapeutic;Thrombosis;Thrombospondin 1;Tight Junctions;TNF gene;transcriptome sequencing;Up-Regulation;Vaccination;Vaccines;varicella zoster virus vasculopathy;Vascular Dementia;Vascular Diseases;Vascular Endothelial Cell;Vasculitis;Viremia;Virus Activation;Virus Diseases;Zoster Vaccine

PROJECT_TITLE: Pathogenic exosomes during herpes zoster mediate increased vascular dementia risk

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-V (91)]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Crohn's Disease;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease

ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PUBLIC HEALTH RELEVANCE Genetics contribute significantly to the risk of developing an inflammatory bowel disease (IBD). In this project, we aim to determine how IBD-associated genetic variants contribute to changes in tissue biology. Understanding these mechanisms will increase our understanding of IBD and provide avenues for therapeutic interventions.

PI_NAMEs: FUREY, TERRENCE S. (contact);SHEIKH, SHEHZAD Z.

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Address;Affect;Alleles;Alternative Splicing;Binding;Biocompatible Materials;Biological Assay;Biology;Blood;causal variant;Cell Physiology;Cells;Chemicals;Chromatin;Cleavage Under Targets and Release Using Nuclease;Code;cohort;Colon;Complement;Crohn's disease;Data;Disease;Ensure;Epithelial Cells;Freezing;Gene Expression;Gene Expression Regulation;Gene Targeting;Genes;Genetic;Genetic Diseases;Genetic Transcription;genetic variant;Genetic Variation;genome wide association study;genome-wide;genomic locus;Genotype;Goals;histone modification;Human;human tissue;ileum;Individual;Inflammatory Bowel Diseases;intestinal epithelium;Intestines;Link;Luciferases;Molecular;molecular scale;monolayer;multiple omics;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Nucleic Acid Regulatory Sequences;patient population;Patients;Permeability;Physiological;Play;Protein Isoforms;Proteins;Protocols documentation;public health relevance;Quantitative Trait Loci;recruit;Regulation;Regulatory Element;Reporter;Risk;risk variant;RNA Splicing;Role;Sample Size;Sampling;study population;success;System;Therapeutic Intervention;Tissue Sample;Tissues;transcription factor;transcriptome sequencing;Translating;Untranslated RNA;Variant;Work

PROJECT_TITLE: Multi-omic characterization of genetic variants in IBD risk loci

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-C (O1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Dementia;Maternal Health;Maternal Morbidity and Mortality;Neurodegenerative;Neurosciences;Pediatric;Pregnancy;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

PHR: PROJECT NARRATIVE Placentally-mediated adverse pregnancy outcomes (APO), including hypertensive disorders of pregnancy, preterm birth, and fetal growth restriction, may play an underrecognized role in the development of Alzheimer's disease and related dementias (ADRD), through biological processes such as vascular endothelial dysfunction and angiogenic dysregulation. The overall goal of this study is to capitalize on an ongoing, multi-ethnic cohort study, the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be Heart Health Study, to 1) determine whether those with and without history of APO differ in brain magnetic resonance imaging ADRD risk markers, 10-15 years after the first pregnancy, and 2) correlate levels of the angiogenic regulatory protein placental growth factor (PlGF), measured during and after the index pregnancy, with the same imaging markers, in study participants with and without a history of APO. This will be the first study to use prospectively collected pregnancy data and biomarkers to investigate the relationship between APO, angiogenic dysfunction, and future maternal ADRD risk.

PI_NAMEs: MILLER, ELIZA C (contact)

PROGRAM_OFFICER_NAME: ANDERSON, DALLAS

PROJECT_TERMS: Academic Medical Centers;Address;adjudication;adverse pregnancy outcome;Affect;Alzheimer's disease related dementia;Ancillary Study;Anisotropy;Atrophic;Biological Markers;Biological Process;Blood;Blood Vessels;Brain;brain magnetic resonance imaging;Cardiac health;cardiovascular risk factor;Cerebrovascular Circulation;Cerebrovascular Trauma;Child;Cognitive aging;cohort;Cohort Studies;Conceptions;Data;dementia risk;Development;Diffusion Magnetic Resonance Imaging;Enrollment;Ethnic Origin;Exhibits;Fetal Growth Retardation;First Pregnancy Trimester;follow-up;Functional disorder;Future;genetic regulatory protein;Geography;Goals;gray matter;Hypertension;Image;imaging biomarker;Impaired cognition;indexing;Indiana;Individual;Infrastructure;interest;late life;Life Cycle Stages;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Maternal-fetal medicine;Measures;Mediating;Mediation;Medical center;middle age;Monitor;Mothers;multi-ethnic;Nerve Degeneration;Neurocognitive;neuroimaging;Nulliparity;Outcome;Outcome Study;Participant;Pathway interactions;Persons;PGF gene;Phenotype;Placenta;Play;post pregnancy;Pregnancy;pregnancy disorder;Pregnancy Outcome;pregnant;Premature Birth;prospective;Prospective Studies;Prospective, cohort study;Race;Recording of previous events;regional difference;Reproductive History;Risk Marker;Role;Second Pregnancy Trimester;Site;social health determinants;socioeconomic diversity;Thick;Universities;vascular cognitive impairment and dementia;vascular endothelial dysfunction;Visit;white matter;White Matter Hyperintensity;Woman

PROJECT_TITLE: Investigating Pathways from Adverse Pregnancy Outcomes to Alzheimer's Disease and Related Dementias: the nuMoM2b-Brain Study

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) is the most common cause of dementia and a leading cause of death in the United States, with no effective treatments to slow or halt disease progression. This proposal will develop an assay to visualize the secretion and spreading of nano-sized extracellular vesicles (EVs) in the brain, a process with great relevance to AD pathophysiology, diagnosis, and treatment.

PI_NAMEs: WAITES, CLARISSA LEIGH (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Acceleration;adenovirus mediated delivery;Affect;aged;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease risk;Alzheimer's disease therapeutic;Alzheimer’s disease biomarker;Amyloid beta-Protein;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Biological Assay;Biological Markers;Biological Process;Biology;Blood;Blood - brain barrier anatomy;blood-brain barrier crossing;Body Fluids;Brain;brain cell;Brain region;brain tissue;Cause of Death;CD81 gene;Cell Communication;Cell secretion;cell type;Cells;Complex;Confocal Microscopy;Coupled;delivery vehicle;Dementia;dentate gyrus;Dependovirus;Development;Diagnosis;diagnostic biomarker;Disease;Disease Progression;Drug Delivery Systems;Drug vehicle;effective therapy;Enhancers;Environment;Etiology;experimental study;extracellular vesicles;Fluorescence;Functional disorder;Genes;genetic risk factor;Genotype;granule cell;Green Fluorescent Proteins;Homeostasis;Human;image reconstruction;Immune response;In Vitro;in vivo;intercellular communication;Intercellular Fluid;interest;Label;Ligands;Light;Lipids;Mediating;Membrane Proteins;Methods;Microscopy;Monitor;Mus;nanosized;neuroinflammation;Neurons;neurotoxicity;novel;Nucleic Acids;Pathogenicity;Pathology;Pattern;Physiologic pulse;Physiological;Process;promoter;Proteins;Research;Resolution;Rhodamine;Risk;Risk Factors;Role;Secretory Vesicles;Silicon;Synaptic plasticity;tau Proteins;Techniques;temporal measurement;Testing;Therapeutic;Three-Dimensional Image;Time;Tissue Harvesting;Tissues;tool;Travel;treatment strategy;United States;uptake;Urine;Vesicle;vesicular release;Visualization;Visualization software

PROJECT_TITLE: A pulse-labeling assay to track extracellular vesicle spreading in the brain

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: SHREVEPORT

ORG_NAME: LOUISIANA STATE UNIV HSC SHREVEPORT

ORG_STATE: LA

PHR: Population-bases studies have observed a long-term association between “silent brain ischemia (SBI)” and an increased risk of dementia and Alzheimer's disease (AD). Therefore, research studies to determine the underlying mechanisms and search for approaches to prevent or treat SBI-accelerated AD dementia are urgently needed. This proposal meets this critical need as it will examine the pathogenesis of SBI-accelerated AD dementia by using a SBI model combined with a novel clinically relevant transgenic AD rat model, and will evaluate the therapeutic efficacy of non-invasive pulsed laser therapy for the treatment of SBI-AD dementia.

PI_NAMEs: ZHANG, QUANGUANG  (contact)

PROJECT_TERMS: abeta accumulation;abeta deposition;Ablation;absorption;Acceleration;Affect;aging population;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Animal Diseases;Behavioral;Benign;Blood;Blood - brain barrier anatomy;Blood brain barrier dysfunction;blood damage;Blood Vessels;Brain;Brain imaging;Brain Injuries;Brain Ischemia;Categories;Cell Aging;Cell Line;Cells;Cerebral Ischemia;cerebrovascular;Clinical;clinically relevant;Cognitive;Cystathionine beta-Synthase;cytochrome c oxidase;Dementia;dementia risk;Diagnosis;disability;Disease Progression;DNA;DNA Damage;DNA Repair;efficacy evaluation;Emergency Situation;Endothelium;Extravasation;Functional disorder;functional improvement;Generations;healing;Health;Heart Arrest;Hemoglobin;Hydrogen Sulfide;Imaging Techniques;Impaired cognition;improved;Incidence;innovation;Investigation;Ions;Ischemia;Lasers;Life;Light;Link;Low-Level Laser Therapy;Mechanics;Mediating;Mitochondria;Modeling;Nerve Degeneration;Neurobehavioral Manifestations;Neurologic;neurovascular;neurovascular coupling;novel;Outcome;Pathogenesis;Pathologic;Patients;Penetration;Persons;photobiomodulation;Photons;Physiologic pulse;Play;Population Study;preservation;prevent;Prevention;Production;Public Health;Rat Transgene;Rattus;repaired;Research;research study;response;Risk;Role;senescence;Severities;Signal Transduction;Signaling Molecule;Societies;Stroke;Study models;Symptoms;System;Testing;Therapeutic;therapeutic development;Time;Tissue Preservation;Transgenic Organisms;Treatment Efficacy;United States;Vascular Endothelial Cell;Work

PROJECT_TITLE: Silent brain ischemia accelerates Alzheimer's dementia: pathogenesis and laser treatment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Q (55)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE The proposed study is relevant to public health since in Mexico, marginalized urban populations have a disproportionately high physical inactivity and noncommunicable disease burden. It is imperative to identify and deploy effective approaches that improve the uptake of evidence-based, contextually-relevant physical activity interventions in high need areas. A project of this scale can have a profound effect on health inequities in Mexico, and has the potential of informing translation and scale-up of evidence-based urban health interventions in other global settings, including Latino communities in the US.

PI_NAMEs: SALVO, DEBORAH  (contact)

PROGRAM_OFFICER_NAME: JONES, NANCY LYNNE

PROJECT_TERMS: Acceleration;access disparities;Address;Adoption;Area;Behavior;built environment;burden of illness;Cessation of life;Cities;Climate;cohesion;Collaborations;Communities;community engagement;concept mapping;cost effective intervention;cost estimate;Country;Diabetes Mellitus;Disease;disease disparity;disorder prevention;Dissemination and Implementation;dissemination science;Economics;Educational workshop;Effectiveness;effectiveness testing;Equity;evidence base;Evidence based intervention;Evidence based practice;exercise intervention;experience;Feasibility Studies;Focus Groups;Goals;Health;health disparity;health inequalities;Healthy Eating;Hybrids;implementation framework;implementation intervention;implementation science;implementation strategy;improved;Income;Inequity;Infrastructure;innovation;International;Intervention;Interview;Latin American;Latino;Leisures;low and middle-income countries;Low income;Maintenance;Malignant Neoplasms;marginalization;member;Mental Health;Methods;metropolitan;Mexican;Mexico;Modeling;Neighborhoods;Obesity;Outcome;Peripheral;Persons;Physical activity;physical inactivity;Population;Poverty;Prevention Research;programs;Public Health;public health emergency;Quality of life;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Activity;Research Personnel;resilience;Risk Factors;Safety;scale up;Science;Social Interaction;study population;Surveys;Testing;Time;Translations;Underserved Population;uptake;Urban Community;Urban Health;Urban Population;urban setting;Urbanization;Vulnerable Populations;Work

PROJECT_TITLE: Contextually responsive implementation of place-activation interventions for promoting physical activity in marginalized urban peripheries in Mexico

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-P (50)]


NIH_SPENDING_CATS: Clinical Research;Cystic Fibrosis;Digestive Diseases;Infectious Diseases;Lung;Microbiome;Nutrition;Pediatric;Rare Diseases

PHR: NARRATIVE The goal of this K24 renewal is to provide ongoing salary and research support for Dr. Hoffman to allow him to focus 25% of his time mentoring clinical fellows, students, junior faculty and other trainees in patient-oriented research on the microbial determinants of chronic diseases in children. This proposal will allow Dr. Hoffman to continue his successful, translational research program, integrate fellows and junior faculty into the program, and maintain and refine his mentorship and leadership skills, by providing protected time, research and computational support, an advisory committee focused on his mentorship, and other resources so that he can mentor current and new early-career researchers specifically working in patient-oriented research.

PI_NAMEs: HOFFMAN, LUCAS R (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Adult;Advisory Committees;Age;Airway Fibrosis;Antibiotic Therapy;Antibiotics;bench-to-bedside translation;Bile Acids;Biological;Biological Markers;Body System;Bronchoalveolar Lavage;career;Caring;Child;Childhood;Chronic;Chronic Disease;Clinical;clinical center;Clinical Data;Clinical Research;Collaborations;Communicable Diseases;Computer Analysis;Core Facility;Cystic Fibrosis;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Development;Discipline;Disease;Doctor of Philosophy;doctoral student;dysbiosis;Ecology;effective therapy;Enrollment;Environment;experience;Faculty;Failure;fecal metabolome;fecal microbiome;Fellowship;Funding;Future;Gastroenterology;gastrointestinal;Gastrointestinal Diseases;gastrointestinal function;Gastrointestinal tract structure;Genetic Diseases;Goals;gut microbiome;Impairment;improved;Infant;Infrastructure;Inhalation;Institutional Review Boards;interest;Laboratories;Leadership;Link;Lower respiratory tract structure;Malabsorption Syndromes;Measures;Medicine;Mentors;Mentorship;metabolome;Methods;microbial;Microbiological Techniques;Microbiology;microbiome;microbiome analysis;microbiome sequencing;microbiota;Molecular;Morbidity - disease rate;mortality;Multicenter Studies;novel;Nutrient;nutrition;Nutritional;Observational Study;Organ;Oropharyngeal;oropharyngeal swab;Outcome;Parents;Participant;pathogen;Pathogenesis;patient oriented;patient oriented research;Patients;Persons;Pharmaceutical Preparations;Physicians;Process;Productivity;Program Development;programs;Proteins;Proxy;Pulmonary Cystic Fibrosis;Pulmonology;Research;research and development;Research Personnel;Research Project Grants;Research Support;Residual Neoplasm;Resources;respiratory;respiratory microbiome;Respiratory Tract Infections;response;Sampling;Scientist;skills;Sputum;stool sample;student mentoring;student training;Students;Study Subject;System;Testing;Time;Training;training opportunity;Translational Research;translational research program;Universities;Upper respiratory tract;Visit;Wages;Washington;Work

PROJECT_TITLE: Patient-oriented microbiome and advanced culture approaches to identifying the microbial determinants of chronic pediatric disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-G (O1)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Fatigue Syndrome (ME/CFS);Clinical Research

ORG_CITY: DAVIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Identifying new laboratory tests that can measure the progression of ME/CFS will directly improve the diagnosis and treatment of ME/CFS and contribute to our understanding of mechanisms underlying ME/CFS. This research develops an interdisciplinary approach to assess the recently discovered, oxygen tension-regulated red blood cell capillary velocity as a new laboratory test for ME/CFS and investigate previously unrealized red blood cell cytokine signaling in ME/CFS. Because ME/CFS is a poorly understood, complex, debilitating disease with no specific laboratory diagnostic tests yet, we believe the proposed project is directly relevant to the NIH's mission and should be broadly valuable for research efforts and clinical studies of chronic diseases including recently emerged long COVID.

PI_NAMEs: WAN, JIANDI  (contact)

PROGRAM_OFFICER_NAME: BREEN, JOSEPH J

PROJECT_TERMS: Affect;Age;Binding;Biological Assay;Biology;Blood capillaries;Cell membrane;cerebral capillary;Cerebrovascular Circulation;Cerebrum;Characteristics;Chronic Disease;Chronic Fatigue Syndrome;Classification;clinical diagnosis;Clinical Research;Collaborations;Collecting Cell;Complex;Consumption;COVID-19 survivors;cytokine;Cytokine Signaling;debilitating symptom;Development;Diagnosis;Diagnostic;diagnostic strategy;Diagnostic tests;diphosphoglycerate;Disease;disease diagnosis;Disease Progression;Erythrocytes;Exclusion;Exhibits;experience;experimental study;Gender;Goals;Hemoglobin;Human;Hyperemia;Hypoxia;Immune;Impairment;improved;in vivo;insight;interdisciplinary approach;Laboratories;Long COVID;Machine Learning;machine learning algorithm;Measures;Microfluidics;Mission;Molecular;Monitor;multiphoton microscopy;novel;Operative Surgical Procedures;Oxidative Stress;Oxygen;pandemic disease;Participant;Pathologic;Patients;Perfusion;Persons;Phosphate Buffer;Phosphorylation;physical symptom;power analysis;Property;Race;recruit;Reporting;Research;response;Role;Saline;Severity of illness;Symptoms;Technology;Testing;Time;tool;treatment response;United States National Institutes of Health;Work

PROJECT_TITLE: Develop a novel red blood cell-based microfluidic approach to assess and diagnose ME/CFS

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CFS-J (80)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: MADISON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative: This research aims to establish novel markers of cerebrovascular disease (CVD) for the sensitive and specific evaluation of vascular contributions to cognitive impairment and dementia (VCID) by studying non-invasive vascular specific MRI markers in CADASIL, the most common heritable cause of vascular dementia. Through this, we aim to understand the influence of both macrovascular and microvascular disease on CADASIL neurodegeneration and cognition. The degree of vascular disease involvement at various stages (normal cognition, mild cognitive impairment, and dementia) of CADASIL (Notch3 mutation carriers) will then be compared with cognitively unimpaired normal aging participants without known neurodegenerative diseases including Notch3 mutations, thereby facilitating examination of other types of VCID and mixed dementias.

PI_NAMEs: EISENMENGER, LAURA BURNS (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Address;Affect;age related;Aging;aging population;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;American;Amyloid;Arterial Disorder;Arteries;autosome;Benchmarking;Blood capillaries;Blood Vessels;Brain;cerebrovascular;Cerebrovascular Disorders;Cerebrovascular system;Cerebrum;Circle of Willis;Clinical;Cognition;Cognitive;cognitive change;cohort;Cohort Studies;Collaborations;Data;Dementia;design;Dominant Genes;Enrollment;Evaluation;Gene Expression;Gene Mutation;Genes;Health;Hemorrhage;Heritability;human subject;imaging modality;imaging study;Imaging technology;Impaired cognition;in vivo;insight;Knowledge;knowledge base;Lewy Bodies;macrovascular disease;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;member;Mendelian disorder;Methods;Microvascular Dysfunction;mild cognitive impairment;mixed dementia;Modeling;multidisciplinary;Mutate;Mutation;mutation carrier;Nerve Degeneration;Neurodegenerative Disorders;non-invasive imaging;normal aging;North America;NOTCH3 gene;novel;novel marker;Outcome;Participant;Pericytes;Persons;Phenotype;Physiologic pulse;Positioning Attribute;premature;Process;protective factors;Protocols documentation;receptor;recruit;Research;Research Personnel;Risk Factors;Role;Sensitivity and Specificity;Severities;Site;Smooth Muscle Myocytes;Structure;Study models;Study Subject;Subcortical Infarctions;Subcortical Leukoencephalopathy;Symptoms;synucleinopathy;Techniques;Technology;Time;Tissues;Universities;vascular cognitive impairment and dementia;vascular contributions;Vascular Dementia;Vascular Diseases;vascular risk factor;Vascular Smooth Muscle;Wisconsin

PROJECT_TITLE: Non-Invasive MRI Markers to Elicit the Role of Vascular Disease in CADASIL Compared to Normal Aging

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative Alzheimer’s disease (AD) is the most common cause of dementia affecting over 55 million people worldwide, and this number is expected to triple by 2050. This project aims to examine the role of a new mechanism – N- glycosylation – in AD pathogenesis. Findings of this study are anticipated to provide important new insight into AD pathology and are likely to lead to novel therapeutic tools against AD.

PI_NAMEs: ZHAO, JINYING  (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Accounting;Affect;Age;age related neurodegeneration;Aging;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Autopsy;beta-site APP cleaving enzyme 1;Biological;Biological Markers;Biological Process;Blood;Brain;Carbohydrates;Clinical;clinical phenotype;cohort;Collection;Communities;Cultured Cells;Data;Dementia;design;Development;Disease;DNA Methylation;Drosophila genus;Early Diagnosis;effective therapy;Epigenetic Process;epigenomics;fly;follow-up;Freezing;Genes;Genetic;genetic manipulation;genome wide association study;Genomics;Glycoproteins;glycosylation;Goals;Histone Acetylation;Homologous Gene;Human;Immune;Impaired cognition;in vivo;Individual;innovation;insight;Link;Longitudinal cohort;MALDI-TOF Mass Spectrometry;Maps;Measures;Memory;Meta-Analysis;Metabolic;MicroRNAs;mild cognitive impairment;multidisciplinary;Multiomic Data;multiple omics;neoplastic;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;neuropathology;new therapeutic target;Nitrogen;novel;novel diagnostics;novel marker;novel therapeutics;older adult;Onset of illness;Oxygen;Participant;Pathogenesis;Pathology;Pattern;Peripheral;Persons;Phenotype;phenotypic data;Pilot Projects;Play;Polysaccharides;Population;Post-Translational Protein Processing;Precision therapeutics;Prefrontal Cortex;Process;Prospective cohort;Protein Glycosylation;Proteins;religious order study;Resolution;risk prediction;risk stratification;Role;Sampling;Serum;Signal Transduction;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Structure;Study of serum;sugar;tau Proteins;Testing;therapeutic target;Time;tool;transcriptome sequencing;transcriptomics;Validation;Work

PROJECT_TITLE: Brain and blood N-glycome profiling in Alzheimer's disease


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Prevention;Primary Health Care;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Rapid globalization and urbanization continue to escalate the burden of non-communicable diseases (NCDs) across the world, disproportionally affecting low- and middle-income countries (LMICs). To date, trials have documented that task-sharing with Community Health Workers reduces systolic blood pressure and fasting blood glucose and achieves smoking cessation. However, most trials have been done in rural areas, and most trials of CHWs tested management of a single condition, e.g. just hypertension. In this context, we propose to conduct an implementation research study on task-sharing with CHWs for concurrent management of hypertension, diabetes, and smoking in a metropolitan city of Nepal.

PI_NAMEs: NEUPANE, DINESH  (contact)

PROGRAM_OFFICER_NAME: ROPER, REBECCA

PROJECT_TERMS: Addendum;Address;Adoption;Advocate;Affect;aging population;Blood Glucose;Blood Pressure;blood pressure reduction;burden of illness;Cessation of life;Cities;Communities;Community Health Aides;Community Trial;Consolidated Framework for Implementation Research;cost;Dedications;design;Diabetes Mellitus;Disease;Disease Management;disorder control;disorder risk;driving behavior;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness/implementation hybrid;Environment;Epidemiologist;Equity;evidence base;Fasting;Goals;Health;health care delivery;health determinants;Health Professional;Health Status;Healthcare;Home;Hypertension;hypertension control;implementation research;implementation strategy;improved;Institutionalization;Intervention;low and middle-income countries;Maintenance;metropolitan;mHealth;Names;Nepal;Nurses;Outcomes Research;Patients;Phase;Physicians;Policy Maker;premature;Process;prototype;Psychological reinforcement;Qualitative Methods;Randomized;research study;research to practice;Risk Factors;Role;rural area;scale up;Scientist;Site;Smoking;smoking cessation;Structure;System;systematic review;Testing;Time;tool;Trust;urban area;Urbanization;working group

PROJECT_TITLE: Scaling Up Community-based Noncommunicable Disease Research into Practice in Pokhara Metropolitan City of Nepal (SCALE-NCD)


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: PROJECT NARRATIVE Obesity is a major public health problem that requires interdisciplinary and diverse teams to significantly reduce or eliminate its impact on cardiometabolic health outcomes. The OHD PRIDE research training and mentoring program is designed to provide comprehensive mentorship, education and networking opportunities in obesity health disparities research to early career faculty from underrepresented backgrounds. Mentees who are employed or who were trained at Minority Serving Institutions will participate in a two-year program intended to enhance their skills in research, grant writing, and scientific writing. The work of OHD PRIDE Program will contribute to the diversification of biomedical research by increasing the number of early faculty from underrepresented backgrounds who launch independent research careers focused on obesity disparities and related chronic diseases.

PI_NAMEs: BEECH, BETTINA M. (contact);BRUCE, MARINO A;THORPE, ROLAND J.

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Accountability;Adult;adult obesity;Affect;African American;African American population;Applications Grants;Biomedical Research;Body mass index;cardiometabolism;Cardiovascular Diseases;cardiovascular risk factor;career;career development;Categories;Child;Chronic Disease;Chronic Kidney Failure;cohort;Collaborations;Color;Coronary heart disease;Data;Data Analyses;Dedications;design;Development;Disparity;early-career faculty;Education;effective intervention;effectiveness evaluation;Eligibility Determination;ethnic disparity;evidence base;Faculty;Familiarity;Family;Funding;Geographic Locations;geographic population;Grant;Health;Health Disparities Research;health disparity;Hispanic;Hybrids;Hypertension;improved;Individual;Institution;Investments;Journals;Life Cycle Stages;Low income;Manuscripts;meetings;Mentors;Mentorship;Minority-Serving Institution;Morbid Obesity;multiple chronic conditions;National Heart, Lung, and Blood Institute;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Obesity Epidemic;Outcome;Overweight;peer;Phase;Population Heterogeneity;Postdoctoral Fellow;Prevalence;programs;Public Health;racial disparity;recruit;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Research Training;responsible research conduct;Risk Factors;Science;scientific organization;Severities;Site;skills;Stroke;Study Section;success;summer institute;Teacher Professional Development;Training;trend;Underrepresented Populations;United States;virtual;ward;weight loss intervention;Weight maintenance regimen;Woman;Work;Writing

PROJECT_TITLE: Obesity Health Disparities Research PRIDE Program (OHD PRIDE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-G (O2)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Genetics;Human Genome;Methamphetamine;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE There are currently no FDA-approved therapeutics for psychostimulant use disorders, and our understanding of the neurobiological changes underlying the intensification of methamphetamine craving over increasing periods of abstinence is limited. The role of key projections from the nucleus accumbens in mediating the incubation of methamphetamine craving will be delineated. This project will also use state of the art molecular techniques to identify cell type-specific changes in gene expression and chromatin accessibility in the rat nucleus accumbens associated with the incubation of methamphetamine craving.

PI_NAMEs: SWINFORD-JACKSON, SARAH E. (contact)

PROGRAM_OFFICER_NAME: MCCLURE-BEGLEY, TRISTAN DAVID

PROJECT_TERMS: Abstinence;ATAC-seq;Attenuated;Behavior;Bioinformatics;Candidate Disease Gene;career;Cell Nucleus;cell type;Cells;Chromatin;Cocaine;cocaine seeking;Collaborations;Coupled;Coupling;craving;Data;Deep Brain Stimulation;Dissociation;Dopamine D1 Receptor;Dopamine D2 Receptor;drug craving;Drug Modulation;drug of abuse;Dwarfism;Electrophysiology (science);Epigenetic Process;experience;experimental study;FDA approved;Female;Gene Delivery;Gene Expression;Genes;genetic manipulation;genome-wide;Globus Pallidus;in silico;Incubated;interest;knock-down;Knowledge;male;Mediating;Mentors;Methamphetamine;Methodology;Modeling;Modification;Molecular;neural circuit;Neurobiology;Neurons;Nucleus Accumbens;Opioid;optogenetics;overexpression;patch clamp;Pharmaceutical Preparations;Play;Population;prolonged abstinence;Rat Transgene;Rattus;receptor;Relapse;Research;Research Project Summaries;Research Proposals;Rodent;Role;selective expression;Self Administration;single cell sequencing;single nucleus RNA-sequencing;skills;stimulant use disorder;Sucrose;Synaptic plasticity;Techniques;Testing;Therapeutic;Time;Training;transcriptome sequencing;transcriptomic profiling;transcriptomics;Validation;Ventral Tegmental Area;Viral;Work

PROJECT_TITLE: Molecular mechanisms of incubation of methamphetamine craving

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

PHR: PROJECT NARRATIVE The goals of this project are to determine the protective effects of APOE-R136S on APOE4-driven neural network dysfunction, behavioral deficits, pathologies, and transcriptomic alterations in novel mouse models of AD and to explore the underlying cellular, molecular, and transcriptomic mechanisms. The findings from this study will help to identify novel mechanisms and targets for therapeutic development for treating Alzheimer’s disease.

PI_NAMEs: HUANG, YADONG  (contact);ZILBERTER, MISHA YURI

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: 3-Dimensional;abeta accumulation;Affect;Age;age related;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid beta-Protein;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Behavioral;Brain region;Cell Culture Techniques;Cognition;Dose;early onset;Early Onset Alzheimer Disease;extracellular;Frontotemporal Dementia;Genes;Genetic;genetic risk factor;Goals;Hippocampus;Human;hyperphosphorylated tau;insight;Knock-in;Late Onset Alzheimer Disease;Molecular;mouse model;Mus;mutant;Mutation;Nature;network dysfunction;neural network;Neurofibrillary Tangles;Neurons;novel;Onset of illness;Pathogenesis;Pathologic;Pathology;Performance;presenilin-1;prevent;protective effect;Protein Isoforms;rare variant;Role;Senile Plaques;single nucleus RNA-sequencing;targeted treatment;tau mutation;tau Proteins;therapeutic development;therapy development;transcriptomics;Variant;Virulence Factors

PROJECT_TITLE: Study Alzheimer's Disease Protective APOE Variants