NIH_SPENDING_CATS: Infectious Diseases

ORG_DEPT: CHEMISTRY

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative This proposal describes the development of chemical and biochemical tools to probe the incorporation of bacterial sugars into the cell surface. In doing so, we will provide a better understanding of bacterial cell envelope assembly, and the molecular recognition of unique (rare) bacterial sugars during host-pathogen interactions. The outcome of this work has applications in the development of long sought-after antibiotics to treat Gram- negative bacterial infections, and will provide a fundamental understanding of bacterial glycosyltransferase function.

PI_NAMEs: LUPOLI, TANIA  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Antibiotics;Area;Bacteria;Bacterial Polysaccharides;Bacterial Proteins;Bar Codes;biochemical tools;Biochemistry;Biology;Cause of Death;cell envelope;Cell surface;Chemicals;Development;Educational process of instructing;Environment;Epitopes;glycosyltransferase;Gram-Negative Bacteria;Gram-Negative Bacterial Infections;Human;improved;Infection;insight;interdisciplinary approach;Label;Laboratories;Mediating;Membrane;Microbiology;Molecular;Molecular Chaperones;molecular recognition;Monosaccharides;novel diagnostics;novel strategies;O Antigens;Oligosaccharides;Organic Chemistry;Organism;Outcome;pathogen;pathogenic bacteria;Pathway interactions;Pattern;Planets;Polymers;Polysaccharides;Predisposition;Production;programs;protein protein interaction;Proteins;Public Health;Reagent;Route;Skin;small molecule;Structure;sugar;Surface;symbiont;Work

PROJECT_TITLE: MIRA: Probing Glycan Polymer Patterns on Bacterial Cell Surfaces

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-U(55)R]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Radiation Oncology

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative As the management of multiple intracranial metastases is rapidly evolving, the demands for detection and delineation of a large number of potentially very small metastatic lesions in the brain on 3D magnetic resonance images (MRI) are increasing dramatically. We aim to develop an artificial intelligence (AI) system to assist both the radiologist as well as radiation oncologist in their roles in management of patients with multiple tumors metastatic to the brain. The intended clinical utilities of the system will be evaluated through observer studies and radiation dose analyses.

PI_NAMEs: CAO, YUE  (contact)

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: 3-Dimensional;Address;Anatomy;Architecture;Artificial Intelligence;Binding;Blinded;Brain;Clinic;Clinical;clinical imaging;Clinical Management;Clinical Treatment;Computer Assisted;Data;deep learning;deep neural network;Detection;detection method;detector;Diagnosis;Dose;Equilibrium;Expert Systems;Feedback;Image;improved;Industrialization;industry partner;Inferior;Injections;Institution;Lesion;Magnetic Resonance Imaging;Medical;Metastatic malignant neoplasm to brain;Michigan;Neoplasm Metastasis;neural network;New York;North Carolina;object recognition;Patient imaging;Patients;Performance;Physicians;Quality of life;Radiation Dose Unit;Radiation Oncologist;Radiation therapy;radiologist;Radiosurgery;Research Personnel;response;Role;Structure;System;Techniques;Technology;Testing;Therapeutic;Time;tool;Training;training data;Translating;treatment planning;treatment response;tumor;Tumor Volume;Uncertainty;Universities;Variant

PROJECT_TITLE: A clinical tool for automated detection and delineation of intracranial metastases from MRI


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: NARRATIVE Despite the increase in disease burden in the areas of kidney, urology and hematology, there is a shortage of workforce to advance scientific discoveries and technology for all Americans. The Commonwealth of Virginia is home to 3 major centers for biomedical research, but they remain somewhat isolated due to distance between institutions. Furthermore, undergraduate students in the Commonwealth that are underrepresented in science may not have adequate access or exposure to KUH training opportunities. The Integrated Virginia Research Training Centers in Kidney, Urology and Hematology (IGNITE KUH) was designed to address these limitations by developing a collaborative and integrated partnership involving three major research training centers in the Commonwealth of Virginia that are committed to developing the next generation of diverse KUH researchers.

PI_NAMEs: CHAPPELL, JOHN CHRISTOPHER;LLOYD, JOYCE A.;OKUSA, MARK DOUGLAS (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Address;American;Appalachian Region;Area;Award;Biomedical Engineering;Biomedical Research;burden of illness;career;catalyst;Clinical and Translational Science Awards;clinical center;Clinical Research;Clinical Sciences;Collaborations;college;COVID-19 pandemic;Data Science;design;Development;Dialysis procedure;Discipline;Disease;Doctor of Medicine;Doctor of Philosophy;drug discovery;Education;Educational process of instructing;efficacy evaluation;End stage renal failure;Enrollment;Environment;Event;Exposure to;faculty mentor;Fostering;functional genomics;fundamental research;Funding;Future;Goals;Growth and Development function;Health;Healthcare;Hematology;Historically Black Colleges and Universities;Home;Human Resources;Immunity;Inflammation;innovation;Institution;inter-institutional;Investigation;Kidney;Kidney Diseases;Kidney Transplantation;Medicine;Mentors;Modernization;nanotherapeutic;next generation;outreach;parity;Pathway interactions;Patient Care;peer;Phase;Population Heterogeneity;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Predictive Analytics;Program Development;Program Evaluation;programs;prospective;recruit;Research;Research Institute;Research Methodology;Research Personnel;Research Training;Resource Development;Resources;Rural;Science;Scientific Advances and Accomplishments;Services;Students;Surveys;Systems Biology;Technology;Telecommunications;Teleconferences;telehealth;Telemedicine;tool;Training;training opportunity;Training Programs;translational health science;Translational Research;undergraduate student;underrepresented minority student;underserved students;United States National Institutes of Health;Universities;Urology;Virginia;Work

PROJECT_TITLE: Integrated Virginia Research Training Centers in KUH (IGNITE KUH)


NIH_SPENDING_CATS: Hematology;Kidney Disease

PI_NAMEs: OKUSA, MARK DOUGLAS (contact)

PROJECT_TERMS: Advisory Committees;Award;Career Mobility;Collaborations;Committee Members;Communication;Communities;conflict resolution;Decision Making;design;Development;Disease;Diverse Workforce;Ensure;Environment;equity, diversity, and inclusion;Evaluation;Future;Goals;Grant;Hematology;innovation;Institution;Kidney;Leadership;Legal patent;Measures;member;Minority Groups;Modeling;Monitor;next generation;Outcome;Outcome Measure;Outcomes Research;Patient Care;Postdoctoral Fellow;pre-doctoral;Process;programs;Publications;recruit;Reporting;Research;Research Personnel;Research Training;Resources;Schedule;Services;skills;Structure;success;Surveys;synergism;Training;underrepresented minority student;underserved community;Universities;Urology;Virginia

PROJECT_TITLE: IGNITE KUH Administrative Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE The overall goal of this proposal is to demonstrate the potential neuroprotective role of adropin, a newly identified endogenous peptide, in subarachnoid hemorrhage-associated cerebral infarction. The proposed research is relevant to public health because it will help to understand the potential therapeutic value of adropin to reduce brain damage and improve neurological recovery following subarachnoid hemorrhage and lead to the development of novel therapeutic strategies. Thus, this proposal is relevant to the part of NINDS's mission that pertains to developing significant knowledge in basic research that will create the foundation for treating subarachnoid hemorrhage and reduce the burden of this neurological disease.

PI_NAMEs: HOH, BRIAN LIM (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Acute;Adhesions;antagonist;Astrocytes;Autologous;Basic Science;beta Actin;Binding Proteins;Biological Assay;Biological Availability;Blood;Blood Platelets;Brain;brain endothelial cell;Brain Injuries;C57BL/6 Mouse;Cerebral Edema;Cerebral endothelium;Cerebral Infarction;Cerebrovascular Circulation;Cerebrovascular Spasm;Cerebrum;Cessation of life;chromatin immunoprecipitation;clinical translation;Clinical Trials;Cognitive deficits;Data;Development;disability;Endothelial Cells;Erythrocytes;experimental study;Florida;Foundations;Functional disorder;Gene Expression;Goals;Hemoglobin;Hemorrhage;Hour;Human;improved;In Vitro;Infarction;inhibitor;Injections;Injury;Intraventricular;Ischemia;Knock-out;Knockout Mice;Knowledge;Magnesium Sulfate;Mediating;Mediator;Meta-Analysis;Mission;Modeling;Molecular;monolayer;Mus;National Institute of Neurological Disorders and Stroke;nerve injury;Nervous System Disorder;neurobehavioral;neurological recovery;neuron apoptosis;neuroprotection;neurovascular;Nimodipine;Nitric Oxide;Nitric Oxide Donors;Nitric Oxide Signaling Pathway;Nitric Oxide Synthetase Inhibitor;Nitrogen;NOS3 gene;novel;novel therapeutic intervention;Nucleic Acid Regulatory Sequences;Oral;Outcome;overexpression;Oxidative Stress;Pathway interactions;Patients;peptide hormone;Peptides;Pericytes;Permeability;Phase;Phosphorylation;Placebos;PPAR alpha;pre-clinical;preservation;prevent;Production;prophylactic;protective effect;protein expression;Public Health;radiological imaging;randomized trial;Reactive Oxygen Species;Regulation;Reporter;Research;Research Personnel;response;Role;Simvastatin;Subarachnoid Hemorrhage;Surgical Clips;Therapeutic;therapeutic target;Thrombosis;Tight Junctions;transcriptome sequencing;Transgenes;Transgenic Mice;Uncertainty;Universities;Vasodilation;Vasospasm

PROJECT_TITLE: Neurovascular protection by adropin in acute neural injury from subarachnoid hemorrhage

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


PI_NAMEs: LINDEN, JOEL M. (contact)

PROJECT_TERMS: Acceleration;Address;Applications Grants;Area;Award;Basic Science;Biomedical Research;career;career development;Career Mobility;career networking;Clinical Research;Communication;communication aid;Continuing Education;design;Development;Development Plans;Education;Educational process of instructing;Educational workshop;Emerging Technologies;Ensure;Entrepreneurship;Evaluation;experience;Exposure to;Faculty;Fostering;Future;Hematology;improved;Individual;innovation;Institution;Intellectual Property;Investments;Kidney;Leadership;Learning;lectures;Medical;Medicine;Mentors;Methodology;Online Systems;Oral;pandemic disease;Participant;Patients;Persons;Postdoctoral Fellow;pre-doctoral;product development;Program Development;programs;recruit;remediation;Research;Research Training;Resource Development;Resources;response;Science;Scientist;Series;skill acquisition;skills;strength training;Students;success;symposium;Technical Expertise;Technology;telehealth;Training;Training Programs;Universities;Urology;Virginia;Writing

PROJECT_TITLE: IGNITE KUH Professional Development Core


NIH_SPENDING_CATS: Cancer;Clinical Research;Diabetes;Digestive Diseases;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE The Stanford Clinical Center will continue to lead and actively participate in the research objectives of the Chronic Pancreatitis, Diabetes, and Pancreas Cancer (CPDPC) Consortium by recruiting into the 4 key clinical studies. Collected specimens from these studies will be studied to develop and validate new immunological insights into how chronic pancreatitis progresses and complications develop including diabetes and pancreas cancer. These insights will inform new diagnostic tests and treatments.

PI_NAMEs: PARK, WALTER GWANG-UP (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Abdomen;acute pancreatitis;Adult;Ancillary Study;biological specimen archives;Childhood;chronic pancreatitis;Clinical;clinical center;Clinical Research;Clinical Trials;cohort;Collaborations;cytokine;Data;Data Coordinating Center;data submission;Development;Diabetes Mellitus;Diagnosis;Diagnostic tests;Early Diagnosis;Endocrinology;Ensure;epidemiology study;Evaluation;Fibrosis;Foundations;Image;Immune;Immune signaling;Immune system;Immunologics;Immunology;insight;International;Lead;Longitudinal cohort;Longitudinal cohort study;Malignant neoplasm of pancreas;Molecular;Natural History;novel;novel diagnostics;Pancreatitis;Pathogenesis;Pathogenicity;Patient Recruitments;patient retention;Patients;Prevention;Primary Care;Procedures;Productivity;Prognosis;prospective;Prospective Studies;Protocols documentation;Quality Control;Radiology Specialty;recruit;Recurrence;Research;response;Role;Sampling;Secondary to;Signal Transduction;Specimen;Testing;Time;Translational Research;translational study;validation studies;working group

PROJECT_TITLE: The Stanford Clinical Center for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer


PI_NAMEs: SHARMA, RAHUL  (contact)

PROJECT_TERMS: Adult;Affect;Appalachian Region;Benign;Biological Models;Black American;burden of illness;career;career networking;Caring;catalyst;Child;Collaborations;Communication;Competence;Creativeness;design;Development;Discipline;Disease;diversity and inclusion;Educational Status;Environment;Equity;Ethnic Origin;experience;Faculty;Fostering;Funding;Future;Gender;geographic barrier;Goals;Health Resources;Hematological Disease;Hematology;high school;Historically Black Colleges and Universities;Home;improved;innovation;Institution;inter-institutional;interdisciplinary collaboration;Interdisciplinary Study;interest;Interest Group;junior high school;Kidney;Kidney Diseases;Learning;lower urinary tract symptoms;member;Mentors;Mentorship;Minority Groups;Minority-Serving Institution;Newsletter;next generation;novel;outreach;Participant;Patients;peer;peer coaching;peer networks;Postdoctoral Fellow;pre-doctoral;Program Appropriateness;programs;Race;Research;Research Training;Resources;Rural;Rural Population;Scholarship;Science;Scientist;Sickle Cell Anemia;Site;skills;social;Social Distance;Students;symposium;System;Talents;telehealth;TNFSF15 gene;Training;Training and Infrastructure;Training Programs;translational impact;undergraduate research experience;undergraduate student;Underrepresented Students;Universities;Urology;Virginia;virtual;Vision;Vocational Guidance;web page

PROJECT_TITLE: IGNITE KUH Network Core


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: Newark

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Project Narrative Low back pain, a substantial burden on the global health and social systems, is often attributed to pathological disc mechanics, yet in vivo measures of structural changes from magnetic resonance images have had little success discriminating pathology from natural aging. The objective of this proposal is to provide methodologies for evaluating disc function in vivo, establish a function-based grading scheme for disc health to aid in pathology diagnosis and treatment planning and to develop a transformation matrix between the in vivo and cadaveric conditions for relating research outcomes to clinical applications. The primary impact of this work will be the methodologies and techniques necessary for basic and clinical research to investigate disc pathology and in the long term, clinical tools for the diagnosis and assessment of treatment options for low back pain.

PI_NAMEs: NEWMAN, HARRAH  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: 3-Dimensional;Activities of Daily Living;Age;Aging;Animal Model;base;Basic Science;Cadaver;Characteristics;Classification;Clinical;clinical application;Clinical Research;clinically relevant;Data;Diagnosis;Elements;expectation;Family suidae;Geometry;global health;Health;Health Status;Height;Human;human subject;Image;in vivo;in vivo evaluation;in vivo Model;Intervertebral disc structure;intervertebral disk degeneration;Low Back Pain;Magnetic Resonance Imaging;Maps;Measures;mechanical behavior;mechanical load;Mechanics;Methodology;Methods;Modeling;Motion;normal aging;novel;Outcome;Outcomes Research;Pathologic;Pathology;porcine model;Positioning Attribute;Prone Position;Property;Protocols documentation;Research;Scheme;sex;social;Statistical Models;Structure;success;System;Techniques;Testing;Time;Tissues;tool;trait;Translations;treatment planning;Vertebral column;Work

PROJECT_TITLE: Non-Invasive Evaluation of In Vivo Intervertebral Disc Mechanical Function


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: EUGENE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: Project Narrative—Health Relevance This project will identify pharmacological interventions that improve the length of life and/or the quality of aging in a simple animal model that shares many hallmark features of aging in humans. Data obtained at three assay sites by rigorously testing a genetically diverse test set is anticipated to identify chemical treatments with high potential to be efficacious in a diverse human population. Our study may lead to treatments that protect against physical deterioration, cognitive decline, and disease susceptibility in the elderly human population.

PI_NAMEs: PHILLIPS, PATRICK C. (contact)

PROGRAM_OFFICER_NAME: FOX, JENNIFER THERESA

PROJECT_TERMS: Accountability;Achievement;Adopted;Age;age-related disease;Aging;aging clocks;aging process;American;Animal Model;Back;bioinformatics pipeline;Biological Assay;Biological Models;Biology of Aging;Caenorhabditis;Caenorhabditis elegans;Caregivers;Chemicals;Chronic Disease;Chronology;Clinical Sciences;Collection;Communities;community setting;Computer software;Data;Data Analyses;data centers;Data Coordinating Center;data dissemination;data portal;data repository;database schema;Databases;Dementia;design;Deterioration;Development;Diabetes Mellitus;Disease;Disease susceptibility;Economics;Educational Materials;efficacy testing;Elderly;Elements;extend lifespan;Genes;Genetic;Genetic Drift;Genetic Heterogeneity;genome editing;Goals;hallmarks of aging;hazard;Health;Healthcare Systems;healthspan;healthy aging;Heart;Heterogeneity;High-Throughput RNA Sequencing;Human;human old age (65+);Impaired cognition;improved;innovation;Internet;Intervention;Laboratories;late life;life span;Link;Longevity;Malignant Neoplasms;Maps;Medical Research;Modeling;Mus;Nematoda;Neurodegenerative Disorders;novel;novel strategies;open source;Outcome;Pathway interactions;pharmacologic;Population;Population Heterogeneity;pre-clinical;Price;Privatization;Process;programs;Proportional Hazards Models;Publishing;quality assurance;Quality of life;rate of aging;Recommendation;Records;repository;Reproducibility;Research;Research Personnel;Resistance;Risk Factors;Science;Site;Societies;Standardization;Stress;Structure;Students;success;System;Systems Analysis;Technology;Testing;therapy development;tool;transcriptome sequencing;transcriptomics;Translating;user-friendly;Validation;Variant;Virus Diseases;web portal;web site;whole genome;Work

PROJECT_TITLE: Caenorhabditis Testing Program Data Coordinating Center


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative This project will field the fifteen year follow up of the Study of the Tsunami Aftermath and Recovery (STAR), a large-scale longitudinal study of individuals differentially exposed to the 2004 Indian Ocean tsunami. The data provide unique information on the evolution of population health of a group of 27,000 individuals first interviewed before the tsunami, including biomarker measurements and integrated information on environmental change.

PI_NAMEs: FRANKENBERG, ELIZABETH A (contact);THOMAS, DUNCAN

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: acetone hydrazone;Adolescence;adverse childhood events;Affect;Age;Area;Attention;Behavioral;behavioral response;Biological Markers;Categories;Censuses;Cessation of life;Characteristics;Child;Child Health;Child Welfare;Cicatrix;Cognition;cognitive performance;cohort;Collection;Communities;Community Surveys;Data;data resource;design;Disasters;Documentation;Earthquakes;Education;emerging adult;Emotional;environmental change;Event;Evolution;executive function;experience;Exposure to;Family;follow-up;Frequencies;Health;health assessment;health economics;Height;Heterogeneity;Household;human capital;Hurricane;Imagery;in utero;Indian Ocean;Individual;Indonesia;Infusion procedures;innovation;Interview;Life;Life Cycle Stages;Link;Literature;Long-Term Effects;Longitudinal Studies;Machine Learning;Measurement;Measures;member;Natural Disasters;Natural experiment;Outcome;Outcome Measure;Parents;Pathway interactions;Personal Satisfaction;Persons;Phase;physical conditioning;Policies;Population;population health;Privatization;programs;psychosocial;psychosocial resources;Public Domains;reconstruction;Recovery;Research;resilience;Resources;Respondent;Rest;Science;Scientific Inquiry;sea level rise;Shock;Siblings;Socioeconomic Status;Stress;success;Sumatra;Surveys;Survivors;Time;tool;Tsunami;Variant;Water;weather patterns;young adult

PROJECT_TITLE: Longer term effects of a natural disaster on health and socio-economic status

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: BALTIMORE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Traumatic brain injury (TBI) is a major cause of long-term disability and dementia, afflicting millions of individuals. Chronic pro-inflammatory activation of brain immune cells called microglia contributes to progressive neurodegeneration after injury. In this proposal, we will refine and test a novel strategy to arrest the progression of neurological impairments following TBI by selectively targeting deleterious microglial subpopulations that exhibit dysfunctional mitochondria. Our plan includes testing a clinically safe drug in an animal model of TBI.

PI_NAMEs: POLSTER, BRIAN M (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: 2-oxoglutarate 3-dioxygenase proline;Affective;Animal Model;Antioxidants;Attenuated;behavior test;Binding;Brain;brain cell;Brain Injuries;Cell Fraction;Cells;Chronic;Clinical;clinically relevant;Cognitive;Cognitive deficits;Complex;Consumption;controlled cortical impact;cytokine;Data;Dementia;Disease;Drug usage;effective therapy;efficacy evaluation;Encephalitis;Enzymes;Exhibits;experimental study;Female;Flow Cytometry;Fluorescence;Gene Expression;Genetic;glial activation;Glycolysis;Goals;Histopathology;HMGB1 gene;Hydroxylation;Hypoxia;idebenone;Immune;Impairment;In Vitro;in vitro Model;in vivo;Incubated;Individual;Inflammatory;inflammatory marker;Injury;Interferons;Interleukin-1 beta;Interleukins;Intervention;Knock-out;Long term disability;Lysosomes;male;Mechanics;men;Metabolic;Methods;Microglia;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Monitor;Motor;mouse model;Mus;Nerve Degeneration;Neurologic;Neurologic Deficit;neuroprotection;Nitric Oxide;novel;novel strategies;Outcome;Oxidative Phosphorylation;Oxidative Stress;Oxygen;Oxygen Consumption;Pathogenicity;Pathway interactions;Pharmaceutical Preparations;Phenotype;Positron-Emission Tomography;prevent;Process;Production;progressive neurodegeneration;Proline;Proteins;Proteomics;Quality Control;Reporter;Reporting;Research;response to injury;restoration;Role;Severities;sex;Signal Transduction;Sorting;Source;TBI treatment;Testing;TLR4 gene;translational study;Traumatic Brain Injury;Woman

PROJECT_TITLE: Reprogramming proinflammatory microglia by restoring mitochondrial function

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: GM

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: Project Narrative: Overall Louisiana is in the highest decile for mortality from chronic diseases. The Louisiana Clinical and Translational Research (LA CaTS) Center is an IDeA-CTR dedicated to resolving this devastating health burden by training and promoting clinical and translational research that addresses health disparities and focuses on improving health outcomes in our state. Major areas of research include obesity, diabetes, cardiovascular disease, cancer, and COVID-19, particularly in underrepresented minority and underserved communities.

PI_NAMEs: KIRWAN, JOHN P. (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: Academic Medical Centers;Address;Administrative Supplement;Advisory Committees;Applications Grants;Area;Award;Bioinformatics;Biomedical Research;Biometry;Black race;Cardiovascular Diseases;Center for Translational Science Activities;Chronic Disease;Clinic;Clinical;Clinical Research;Clinical Sciences;clinical translation;Clinical Trials;cohort;Collaborations;Communication;Communities;community advisory board;community engagement;COVID-19;COVID-19 pandemic;COVID-19 patient;COVID-19 testing;COVID-19 vaccination;Dedications;Development;Diabetes Mellitus;Disease Management;Disparity;Diverse Workforce;diversity and inclusion;Education;Ensure;experience;Federally Qualified Health Center;Funding;Generations;Goals;Grant;Growth;Health;health disparity;health equity;health literacy;Health Sciences;Healthcare;Healthcare Systems;high risk population;Hurricane;improved;Infrastructure;Inosine Dialdehyde;Institution;Institutional Review Boards;investigator training;Investments;Long COVID;Longterm Follow-up;Louisiana;Malignant Neoplasms;minority communities;Mission;Modeling;mortality;multidisciplinary;Obesity;operation;Outcome;pandemic disease;Patients;Pediatric Hospitals;Persons;Positioning Attribute;Post-Acute Sequelae of SARS-CoV-2 Infection;precision medicine;precision nutrition;pressure;Productivity;Professional Education;programs;Provider;Public Health;Publications;RADx Underserved Populations;recoverin protein;recruit;Research;Research Infrastructure;Research Personnel;resilience;Resources;response;Role;Rural;rural health clinic;safety net;Scholars Program;School Dentistry;Scientist;Services;skills;social health determinants;Structure;synergism;System;Teacher Professional Development;Testing;Time;Training;Translational Research;Trust;Underrepresented Minority;underserved community;Underserved Population;United States National Institutes of Health;Universities;Vaccination;Veterans;virtual platform;Work

PROJECT_TITLE: Louisiana Clinical and Translational Science Center


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Precision Medicine;Rural Health;Social Determinants of Health;Vaccine Related

PROJECT_TERMS: 2019-nCoV;Acceleration;Address;Administrative Supplement;Advisory Committees;Applications Grants;Award;Biomedical Research;Black race;Businesses;Center for Translational Science Activities;Centers of Research Excellence;Charge;Clinical Research;Clinical Sciences;Clinical Trials;Clinical Trials Unit;cohort;Collaborations;Communication;Communities;community based participatory research;community engagement;community partners;COVID-19;COVID-19 testing;COVID-19 therapeutics;COVID-19 vaccination;Creativeness;design;Elements;Ensure;Environment;Equity;equity, diversity, and inclusion;Faculty;Faculty Recruitment;Felis catus;Fostering;Funding;genome analysis;genome sequencing;Goals;Growth;Health;health disparity;Home;Hurricane;improved;Inosine Dialdehyde;Institution;Leadership;Long COVID;Louisiana;Mission;Monitor;multidisciplinary;National Institute of General Medical Sciences;novel;operation;Outcome;patient population;Population;Post-Acute Sequelae of SARS-CoV-2 Infection;precision medicine;precision nutrition;Pregnancy Complications;Principal Investigator;Process;programs;RADx Underserved Populations;Recommendation;Reporting;Research;Research Infrastructure;Research Personnel;resilience;Resistance;Resource Allocation;Resources;Rural Health;Scholarship;Science;Secure;Services;Strategic Planning;Structure;success;telehealth;Therapeutic Intervention;therapeutic vaccine;Time;tool;Training;Translational Research;translational research program;Trust;Underserved Population;United States National Institutes of Health;Universities;Vaccine Clinical Trial;vaping;Viral Genome;Vulnerable Populations;Women's Health;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: JOHNSON, WILLIAM  (contact)

PROJECT_TERMS: Address;analytical method;Area;Award;Biometry;Center for Translational Science Activities;citizen science;Clinical;Clinical Research;Clinical Sciences;Collaborations;Communities;community based research;community engagement;Community Outreach;Consultations;Data;Dedications;design;Development;Disparity;Education;Ensure;Epidemiology;Faculty;Feedback;Funding;Future;Goals;Grant;Health;health disparity;health equity promotion;high dimensionality;improved;Individual;Institution;Instruction;interest;Investigation;Knowledge;Leadership;lectures;Location;Louisiana;member;Methodology;Outcome;Outcomes Research;Peer Review;Pilot Projects;programs;Publications;quantitative imaging;Reduce health disparities;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Resources;Scientific Advances and Accomplishments;Series;Services;social;sound;Statistical Data Interpretation;Subgroup;success;support network;System;Techniques;Training;Translational Research;translational scientist;transmission process;Trust;Underrepresented Populations;Underserved Population;user-friendly;Vertebral column;virtual;Vision;Work

PROJECT_TITLE: Core 02: Biostatistics, Epidemiology & Research Design Core


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: TULSA

ORG_NAME: OSU CENTER FOR HEALTH SCIENCES

ORG_STATE: OK

PHR: Project Narrative Various adverse and protective environments may affect child development. The Healthy Brain and Child Development National Consortium (HBCD-NC) will follow 7,500 mothers and their children from 24 locations across the U.S. from before birth to 10 years of age to better understand which harmful and protective environments exert the greatest impact on child development. This study will help to improve the health and development of children across the nation.

PI_NAMEs: CROFF, JULIE MAY (contact);HAYS-GRUDO, JENNIFER ;MORRIS, AMANDA S

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: 10 year old;Address;Adverse event;Affect;Alcohols;Behavioral;Biological;Birth;Brain;Caregivers;caregiving;Child;child bearing;Child Development;cohort;Communities;Conceptions;COVID-19;critical period;Data;Data Collection;Data Coordinating Center;data integrity;Data Set;data standards;design;Development;DNA;early experience;early life exposure;Electroencephalography;Enrollment;Environment;Environmental Exposure;Environmental Hazards;Epigenetic Process;Ethics;Ethnic Origin;Event;experience;Exposure to;Feedback;General Population;Genes;Goals;hazard;Health;Helping to End Addiction Long-term;Human;improved;Infant;Infection;innovation;insight;Life;Link;Location;Magnetic Resonance Imaging;Malnutrition;maltreatment;Marijuana;Maternal Health;maternal stress;Measures;Methods;Modality;Monitor;Mothers;multidimensional data;multimodality;neurodevelopment;neuroimaging;Newborn Infant;novel;Opiate Addiction;Opioid;opioid misuse;Outcome;Participant;Persons;Physiological;Population;postnatal;Pregnancy;pregnant;Pregnant Women;prenatal;prenatal exposure;Process;protective factors;Protocols documentation;psychologic;Psychopathology;Public Health;Public Policy;Race;recruit;remote assessment;Research;Research Design;Research Personnel;Sampling;Second Pregnancy Trimester;Severities;Shapes;Site;socioeconomics;sound;Speed;stem;Stress;Structural Racism;substance use;Time;Time Study;Tobacco;tool;Toxicant exposure;Training;United States;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: 10/24 Healthy Brain and Child Development National Consortium

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-D(51)R]


ORG_CITY: IOWA CITY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Overall Project Narrative The University of Iowa Wellstone Muscular Dystrophy Specialized Research Center (MDSRC) promotes the NIH mission by enabling pre-clinical and clinical translational research for dystroglycan-associated muscular dystrophies (dystroglycanopathies), progressive neuromuscular diseases characterized by severe skeletal muscle degeneration. Our MDSRC has a program for successfully training the next generation of muscular dystrophy basic and clinical research investigators, and a nationally recognized core makes available tissues and cells from a shared-resource repository to the broader neuromuscular disease research community. The coordinated focus of the three highly integrated cores (adminsitrative, shared resource and training) and two projects (pre-clincial and clincial research) is to translate discoveries from basic science research to improve diagnosis and treatment of patients with dystroglycanopathy.

PI_NAMEs: CAMPBELL, KEVIN P. (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Acceleration;Advisory Committees;Basic Science;Binding;Biochemical;Biological Markers;Biopsy;Blood;Cell Culture Techniques;cell repository;Cells;Clinical;clinical care;Clinical Research;clinical research site;clinical translation;clinical trial readiness;Clinical Trials;Clinical Trials Design;cohort;Collaborations;Communication;Communities;Community Outreach;Cryopreservation;Development;Diagnosis;Diagnostic;Diagnostic tests;Disease;Dystroglycan;dystroglycanopathy;Environment;Fellowship;Fibroblasts;follow-up;fukutin related protein;Functional disorder;Genes;Genotype;Goals;graduate school;Human Resources;improved;Infrastructure;insight;interest;Iowa;Laboratories;Laminin;Length;Measures;medical schools;Medical Students;member;Mission;Molecular;Motor;mouse model;Muscle;muscle degeneration;Muscle function;Muscular Dystrophies;Myoblasts;Myocardial tissue;Natural History;Neuromuscular Diseases;next generation;novel;novel diagnostics;novel therapeutic intervention;Patient Care;patient engagement;Patients;Pediatric Neurology;Postdoctoral Fellow;pre-clinical;pre-clinical research;programs;Property;Proteins;Proteomics;Qualifying;rational design;receptor function;recruit;Regulation;repository;Research;Research Personnel;Resource Sharing;Resources;Role;Scientist;Severities;Skeletal Muscle;skills;Structure;sugar;Testing;tissue culture;tissue/cell culture;Tissues;Training;training opportunity;Translating;Translational Research;Translations;undergraduate research;undergraduate student;United States National Institutes of Health;Universities;Urine;user-friendly;web site;α-Dystroglycan


PROJECT_TITLE: Core A: Administrative Core


PI_NAMEs: MATHEWS, KATHERINE DIANNE (contact)

PROJECT_TERMS: Acceleration;Affect;Award;Basic Science;Biopsy;career;Career Mobility;Caring;Childhood;Clinic;Clinical;Clinical Trials;Collaborations;college;Communication;Communities;design;Development;Discipline;Disease;Doctor of Philosophy;Education;Educational workshop;Electronic Mail;Enrollment;Environment;Evaluation;experience;Exposure to;Faculty;Family;Feedback;Fellowship;Fostering;Funding;Funding Agency;Goals;Growth;Growth and Development function;Human Resources;improved;Individual;individual patient;interest;Internships;Iowa;Knowledge;Laboratories;Literature;Medical;Medical Students;Medicine;Mentors;Mission;Muscle;Muscular Dystrophies;neurogenetics;Neurologist;Neurology;neuromuscular;Neuromuscular Diseases;Neuromuscular research;neuromuscular training;next generation;Online Systems;Outcome;Pathology;Patient Care;Patient observation;Patient Participation;Patients;Pediatric Neurology;Physicians;Postdoctoral Fellow;programs;Research;Research Personnel;Research Support;Research Training;Residencies;Resources;Rotation;Scientist;Side;Students;Supervision;symposium;Testing;Training;Training Activity;training opportunity;Training Support;Translational Research;translational scientist;undergraduate research;undergraduate student;Universities;web site;Work

PROJECT_TITLE: Core C: Training Core


PI_NAMEs: GOLDMAN, SYLVIA  (contact)

PROJECT_TERMS: Achievement;Address;Area;Attention;Award;Budgets;Businesses;Cardiovascular Diseases;Center for Translational Science Activities;Clinical Research;Clinical Sciences;cohort;Collaborations;Communication;comorbidity;COVID-19;Data;Data Collection;Data Reporting;data visualization;Development;Diabetes Mellitus;Disease;Ensure;Evaluation;Felis catus;flexibility;Funding;Geographic Locations;Goals;Growth;Health;health disparity;improved;Infrastructure;innovation;Institution;Leadership;Louisiana;Malignant Neoplasms;member;Methods;Mission;Monitor;National Institute of General Medical Sciences;Obesity;Outcome;Pathway Analysis;Process;Productivity;program costs;Program Development;programs;Publications;Recording of previous events;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;Resource Allocation;Resources;Services;Shapes;System;tool;Translational Research;Underserved Population;Vision;Visualization software;Vulnerable Populations

PROJECT_TITLE: Core 05: Tracking and Evaluation Core


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Congenital Muscular Dystrophy;Congenital Structural Anomalies;Intellectual and Developmental Disabilities (IDD);Muscular Dystrophy;Neurosciences;Pediatric;Rare Diseases

PI_NAMEs: MOORE, STEVEN A (contact)

PROJECT_TERMS: Amino Acid Substitution;Area;Autopsy;Basic Science;Binding;Biological;Biological Assay;Biological Markers;Biopsy;Blood;Blood specimen;Canada;Cell Culture Techniques;cell repository;Cells;Clinical;Clinical Trials;Clinics and Hospitals;Collaborations;congenital muscular dystrophy;Consent;Country;Cryopreservation;Development;Diagnosis;Diagnostic;Diagnostic Services;Diagnostic tests;Disease;dystroglycanopathy;dystrophinopathy;enzyme structure;Europe;Evaluation;Fibroblasts;Genetic;glycosyltransferase;Goals;Infrastructure;interest;International;Iowa;Laboratories;Laminin;Limb-Girdle Muscular Dystrophies;medical specialties;Muscle;Muscular Dystrophies;Myoblasts;Myocardial tissue;Neuromuscular Diseases;novel diagnostics;Online Systems;Operative Surgical Procedures;Pathology;Pathway interactions;Patients;Positioning Attribute;preclinical study;Procedures;Process;Productivity;Proteins;Protocols documentation;repository;repository infrastructure;Research;research and development;Research Personnel;Research Support;Resolution;Resources;Sampling;Services;Site;Skeletal Muscle;skin biopsy;Techniques;Testing;Therapeutic;tissue culture;tissue/cell culture;Tissues;Translational Research;Universities;Urine;variant of unknown significance

PROJECT_TITLE: Core B: The Muscle Tissue/Cell Repository and Specialty Diagnostics Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Social Determinants of Health;Telehealth

PI_NAMEs: ALEXANDER, DAVID EUGENE (contact)

PROJECT_TERMS: Access to Information;Address;Adoption;Award;burden of chronic illness;career networking;Caring;Catalogs;Center for Translational Science Activities;Clinic;Clinical;Clinical Research;Clinical Sciences;Collaborations;Communication;Communities;community engaged research;community engagement;computing resources;Country;COVID-19;COVID-19 pandemic;Custom;cyber infrastructure;Data;data management;Databases;Development;Disparate;Disparity;Education;Electronic Mail;Felis catus;flexibility;Goals;Grant;Growth;Health;health disparity;Hybrids;improved;Infrastructure;infrastructure development;innovation;Institution;Internet;Louisiana;meetings;Mission;Modeling;Network Infrastructure;operation;Optics;Outcome;pandemic disease;Pediatric Hospitals;personalized approach;post-pandemic;Publications;Reduce health disparities;repository;Research;Research Activity;Research Personnel;Research Project Grants;resilience;Resource Informatics;Resources;scale up;Secure;Services;social media;success;Technology;telehealth;tool;Translational Research;Underserved Population;Update;Videoconferencing;virtual;Vision;web-based tool;website development;Workforce Development

PROJECT_TITLE: Core 08: Cyberinfrastructure Enhancement Core


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Congenital Muscular Dystrophy;Congenital Structural Anomalies;Intellectual and Developmental Disabilities (IDD);Muscular Dystrophy;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

PROJECT_TERMS: Affinity;Binding;Biochemical;Biological Assay;Biopsy;Cells;Clinical;clinical phenotype;Data;Defect;design;Development;Diagnosis;Diagnostic;Diagnostic Procedure;Disease;Dystroglycan;dystroglycanopathy;ECM receptor;enzyme substrate complex;Enzymes;Extracellular Matrix Proteins;Fibroblasts;Functional disorder;Gene Transfer;Genes;Genetic study;Goals;Immunofluorescence Immunologic;Impairment;improved;insight;Laminin;Lead;Length;Limb-Girdle Muscular Dystrophies;Measurement;Measures;Molecular;Monitor;Monoclonal Antibodies;Mus;Muscle;Muscle function;Muscular Dystrophies;Mutation;novel;novel diagnostics;novel therapeutic intervention;Pathogenesis;Pathologic;Pathology;Patients;Physiological;Play;Production;Property;Proteins;rational design;receptor;receptor function;Regulation;Research;Role;Severities;Stains;Structure;sugar;Techniques;Therapeutic;therapeutic effectiveness;therapy development;Treatment Efficacy;Validation;α-Dystroglycan

PROJECT_TITLE: Muscular Dystrophy Specialized Research Center: Project 1


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research

PI_NAMEs: LAMONICA, LEIGH  (contact)

PROJECT_TERMS: Address;Advocacy;animal safety;Area;biomedical informatics;Biometry;burden of chronic illness;Center for Translational Science Activities;Clinical Research;Clinical Sciences;Clinical Trials Design;Collaborations;Communities;community advisory board;community engagement;Community Outreach;Community Participation;Consultations;COVID-19 pandemic;Data Analyses;design;Development;Disease;Disparity;early screening;Economics;Ethical Issues;Ethics;Excision;Feedback;Felis catus;Funding;Goals;Health;Human;IACUC;improved;informal learning;Institution;Institutional Review Boards;interdisciplinary collaboration;Interest Group;Knowledge;Learning;Louisiana;meetings;Mission;Modeling;Monitor;multidisciplinary;Outcome;Participant;Procedures;Process;Protocols documentation;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Subjects;Resources;responsible research conduct;Review Committee;Services;Site;social;sound;Structure;Subgroup;success;Surveys;tool;Training;Translational Research;Trust;working group

PROJECT_TITLE: Core 09: Ethics and Regulatory Knowledge Core


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Congenital Muscular Dystrophy;Congenital Structural Anomalies;Genetics;Intellectual and Developmental Disabilities (IDD);Muscular Dystrophy;Neurosciences;Pediatric;Precision Medicine;Rare Diseases;Telehealth

PROJECT_TERMS: Address;Adult;Age;aged;Agreement;Alleles;Biological Markers;biomarker identification;Blood;candidate marker;candidate validation;Clinical;clinical care;clinical phenotype;Clinical Trials;Clinical Trials Design;cohort;congenital muscular dystrophy;Data Collection;detection method;Disease;disease phenotype;Disease Progression;dystroglycanopathy;early childhood;Evaluation;follow-up;fukutin related protein;Functional disorder;Genes;Genotype;Goals;Grouping;Heterogeneity;Individual;insight;Interview;Life;Limb structure;Longitudinal Studies;Measures;Medical;meetings;minimally invasive;Motor;Muscular Dystrophies;Mutation;Natural History;novel;Outcome;Outcome Measure;Participant;patient biomarkers;Patient Care;patient population;patient stratification;Patients;Peptides;Performance;Phenotype;Physical assessment;Plasma;protein biomarkers;Proteins;Proteomics;Protocols documentation;Rare Diseases;remote assessment;Research;Research Personnel;respiratory;Sampling;Serum;Site;Standardization;Study Subject;telehealth;Telephone;Therapy Clinical Trials;Travel;Urine;Validation;Work

PROJECT_TITLE: Muscular Dystrophy Specialized Research Center: Project 2


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Infectious Diseases

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Despite their profound importance for human health worldwide, the functional and genetic diversity of the highly polymorphic human leukocyte antigens (HLA) and killer cell immunoglobulin-like receptors (KIR) have not been adequately characterized in the Eastern Hemisphere. In addressing these deficiencies, we will test the broad hypothesis that natural selection to local pathogen environments has shaped geographic distribution of HLA and KIR diversity. This work will be critical for understanding and treating multiple immune-mediated and infectious diseases across Asia and the Pacific Island regions, which encompass over half the human population.

PI_NAMEs: NORMAN, PAUL JOHN (contact)

PROGRAM_OFFICER_NAME: KULKARNI, SHILPA S

PROJECT_TERMS: Address;Admixture;Affect;Algorithms;Alleles;analytical tool;Asia;Autoimmune Diseases;Autoimmunity;Bioinformatics;bioinformatics pipeline;cancer risk;Cell Physiology;Cells;Characteristics;Chronic;Chronic Disease;combinatorial;Communicable Diseases;Complex;Country;CRISPR/Cas technology;Data;Development;Disease;Disease susceptibility;Disparity;Donor person;Environment;Evolution;Experimental Designs;experimental study;Far East;fetal;Genes;Genetic;Genetic Polymorphism;genetic variant;Genetic Variation;Genome;Genomic Segment;Genotype;Geographic Distribution;Geographic Locations;Geography;Goals;Haplotypes;Health;High-Throughput Nucleotide Sequencing;Histocompatibility Antigens Class I;HLA Antigens;Human;Human Genome;Immune;Immune response;Immune system;Immunity;Immunogenetics;Immunoglobulins;immunoregulation;Immunotherapy;implantation;Individual;Indonesia;Infection;Inflammation;innovation;Investigation;Killer Cells;Knowledge;Laboratories;Life;Ligands;Link;Malignant Neoplasms;Maps;Mediating;Methods;MHC Class I Genes;Modeling;Morbidity - disease rate;mortality;multi-ethnic;Native-Born;Natural Killer Cells;Natural Selections;Nature;neglect;Nervous System Disorder;novel;novel strategies;Oceania;Organ Donor;Outcome;Pacific Islands;pathogen;pathogen exposure;Pattern;personalized medicine;Phenotype;Population;Predisposition;Pregnancy;pressure;Property;receptor;Registries;reproductive;Research;Resolution;response;Role;Severities;Shapes;Signal Transduction;Southeastern Asia;Specificity;study population;Syndrome;targeted sequencing;Testing;Tissues;training data;trait;Treatment Efficacy;tumor;Underrepresented Populations;Variant;whole genome;Work

PROJECT_TITLE: Evolution and Function of Immunogenetic Diversity across the Eastern Hemisphere

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-F(03)M]


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Patient Safety;Prevention;Primary Health Care;Rural Health;Social Determinants of Health

PI_NAMEs: DAVIS, TERRY C (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Advisory Committees;American Cancer Society;Center for Translational Science Activities;chemotherapy;Chicago;Chronic Disease;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;colon cancer screening;Communities;community advisory board;community clinic;Country;COVID-19;COVID-19 testing;COVID-19 vaccine;design;diabetes self-management;digital applications;digital platform;Disparity population;disparity reduction;Electronics;Enrollment;Equity;Ethnic Origin;Exclusion;Faith;feasibility research;Federally Qualified Health Center;Funding;Goals;Health;health disparity;Health education;health equity;health goals;health literacy;health outcome disparity;Health Technology;Hispanic;Home;hospital care;Imprisonment;Improve Access;improved;Individual;inner city;Institution;Institutional Review Boards;Lead;Leadership;Lesbian Gay Bisexual Transgender Queer;literacy;Louisiana;Low income;Medicaid;medical schools;medication compliance;minority patient;Obesity;Oral;Outcome;outreach;Participant;patient portal;Patient-Focused Outcomes;patient-level barriers;Patients;Population;Prevention trial;Preventive care;Process;Provider;racial diversity;RADx Underserved Populations;recruit;Reduce health disparities;Research;Research Design;Research Institute;Research Personnel;Research Project Grants;Resources;Rural;rural area;rural patients;Services;social health determinants;Texas;Training;treatment trial;Trust;United States Dept. of Health and Human Services;United States National Institutes of Health;Universities;vulnerable community;Vulnerable Populations;Work

PROJECT_TITLE: Core 10: Health Literacy Core


PI_NAMEs: FONSECA, VIVIAN A (contact)

PROJECT_TERMS: Address;Advertising;Affect;Alabama;biobank;Biomedical Research;Cardiovascular Diseases;career;career development;Center for Translational Science Activities;Clinical;clinical center;clinical development;Clinical Research;Clinical Sciences;clinical trial enrollment;cohort;Collaborations;Communication;Communities;COVID-19;COVID-19 pandemic;Dedications;design;Development;Diabetes Mellitus;Discipline;Discipline of Nursing;Disease;Disease Outcome;Disparity population;Distance Learning;early-career faculty;education research;education resources;Educational Curriculum;Educational process of instructing;Educational workshop;Enrollment;equity, diversity, and inclusion;experience;Faculty;Funding;Goals;Grant;Health;health disparity;Health Occupations;Health Sciences;Healthcare;Home;improved;Individual;Infrastructure;Institution;interest;K-Series Research Career Programs;Learning;lectures;Louisiana;Malignant Neoplasms;Master of Science;Medicine;meetings;Mentors;Mentorship;Mission;Nursing Faculty;Obesity;Online Systems;Outcome;Pilot Projects;Play;Positioning Attribute;Postdoctoral Fellow;Process;programs;Public Health;recruit;Recruitment Activity;Reduce health disparities;Reporting;Research;Research Methodology;Research Personnel;Research Training;Resources;Role;Scholars Program;Science;Series;Site;Social Work;stem;Structure;Students;success;System;Targeted Research;Time;tool;Training;Training Programs;Translational Research;translational scientist;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Universities;Update;virtual

PROJECT_TITLE: Core 01: Professional Development Core


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Hepatitis;Liver Disease;Pediatric

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative  Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of liver disease, ranging from nonalcoholic fatty liver to nonalcoholic steatohepatitis (NASH). Nonalcoholic fatty liver disease, and especially NASH, are a leading cause of chronic liver disease in both adults and children, and are associated with increased liver-related morbidity and mortality. The NASH CRN aims to transform innovative scientific discoveries from clinical and translational research to better understand the natural history of the disease, develop a better means of diagnosis and treatment, understand the pathogensis, and reduce the incidence and burden of adverse outcomes due to NAFLD and NASH.

PI_NAMEs: CLARK, JEANNE M;SHADE, DAVID M (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Adult;adverse outcome;Affect;Ancillary Study;Archives;Biological Markers;Biological Specimen Banks;Biometry;Cardiovascular system;Cessation of life;Child;Childhood;chronic liver disease;Cirrhosis;Clinical;clinical center;Clinical Management;Clinical Research;clinical trial implementation;Clinical Trials;Clinical Trials Network;Cohort Studies;Collaborations;Communication;Control Groups;cost;Data;Data Coordinating Center;data management;Development;Diagnosis;digital imaging;disease natural history;Emerging Technologies;Enrollment;Ensure;Ethics;Fibrosis;Funding;Future;Genomics;Health;Hepatic;Histology;Historical Cohort Studies;image archival system;improved;Incidence;Industry;innovation;Institutional Review Boards;Leadership;lipidomics;Liver;Liver diseases;liver transplantation;Losartan;Malignant neoplasm of liver;Malignant Neoplasms;Measures;Metabolic;metabolomics;Metadata;Methods;microbiome research;Mission;Morbidity - disease rate;mortality;multidimensional data;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;neoplastic;non-alcoholic fatty liver;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;North America;novel;novel therapeutic intervention;Outcome;pathogen;Pathogenesis;Patients;pediatric non-alcoholic fatty liver disease;Phase;prevent;Primary carcinoma of the liver cells;Private Sector;programs;Proteomics;Public Health;Publications;Qualifying;Quality Control;Research;Research Design;Research Personnel;response;Safety;Scientist;Therapeutic Clinical Trial;Translational Research;treatment strategy;treatment trial;United States;United States National Institutes of Health

PROJECT_TITLE: Continuation of the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) Data Coordinating Center


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: SARPONG, DANIEL F (contact)

PROJECT_TERMS: Address;Applications Grants;Award;Biomedical Research;Categories;Center for Translational Science Activities;clinical center;Clinical Research;Clinical Sciences;Communication;Communities;community academic partnership;community advisory board;community based participatory research;community center;community engaged research;community engagement;Community Health;Community Health Systems;community involvement;community organizations;Community Outreach;community partners;community partnership;community setting;Development;Disease;Education;effective intervention;falls;Federally Qualified Health Center;forging;Fostering;Foundations;Funding;Goals;Health;Health behavior;health disparity;health equity;Health Priorities;Health Promotion;Healthcare;improved;Infrastructure;Institution;Interest Group;Intervention;Knowledge;Louisiana;member;Mentorship;Minority Groups;Mission;Online Systems;Outcome;outreach;Persons;Pilot Projects;Population Study;practice-based research network;Primary Care Physician;Process;programs;Recording of previous events;recruit;Reduce health disparities;Research;Research Design;Research Personnel;Research Priority;Research Project Grants;Resources;Scholars Program;Secure;Services;Side;social health determinants;study population;success;systems research;Training;translational engagement;Translational Research;translational scientist;Trust;Underserved Population;Vision;Work

PROJECT_TITLE: Core 03: Community Engagement and Outreach Core


PI_NAMEs: OCHOA, AUGUSTO C. (contact)

PROJECT_TERMS: Address;Affect;Award;burden of chronic illness;Center for Translational Science Activities;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;COVID-19;Development;Disease;diversity and inclusion;Ensure;Extramural Activities;Faculty;Felis catus;Financial Support;Fostering;Funding;Funding Opportunities;Future;Goals;Grant;Health;health disparity;health equity promotion;Healthcare;Home;improved;Infrastructure;innovation;Institution;inter-institutional;investigator training;Investments;Learning;Louisiana;Manuscripts;Methods;Minority Groups;minority investigator;novel;Outcome;Peer Review;Pilot Projects;Population;Procedures;programs;Publishing;Recommendation;Reduce health disparities;Research;Research Personnel;Research Project Grants;Research Technics;Research Training;Resources;Scholars Program;Science;Senior Scientist;Strategic Planning;success;Training;Training and Education;training opportunity;Translating;translational physician;Translational Research;translational scientist;Translations;Underrepresented Minority;United States National Institutes of Health;visiting scholar;Work

PROJECT_TITLE: Core 04: Pilot Projects Program


ORG_CITY: BIRMINGHAM

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Public Health Relevance Statement CD4+ T cell differentiation has a big impact on both cellular and humoral immune responses. Memory T cell formation is also the scientific basis for the development of many vaccines. Our proposal to understand CD4+ T cell differentiation and memory will provide important knowledge on how to control infectious diseases, autoimmune disorders, and to aid vaccine development for new pandemic threats.

PI_NAMEs: HU, HUI  (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: arm;Autoimmune Diseases;B-Lymphocytes;BACH2 gene;Biological Models;BLR1 gene;CD4 Positive T Lymphocytes;Cell Differentiation process;Cells;Chromatin;Communicable Diseases;Complex;cytokine;cytotoxic;Data;design;Development;Generations;Genes;Goals;Helper-Inducer T-Lymphocyte;Humoral Immunities;IL2RA gene;Immune response;Immunization;infectious disease treatment;Inflammatory;Interleukin-6;intraperitoneal;Knowledge;Maintenance;Maps;Memory;memory CD4 T lymphocyte;Modeling;Molecular;mouse model;Mus;new pandemic;novel;novel marker;pandemic potential;pandemic response;Pathway interactions;Population;Positioning Attribute;Process;programmed cell death protein 1;Proteins;public health relevance;receptor;Regulation;Reporter;Research;response;Role;single cell ATAC-seq;single-cell RNA sequencing;Structure of germinal center of lymph node;T cell differentiation;T cell response;T memory cell;T-Lymphocyte Subsets;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;vaccine development;vaccine strategy;Vaccines;Work

PROJECT_TITLE: Transcriptional Regulation of CD4+ T Cell Differentiation and Diversified Memory

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Data Science;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Social Determinants of Health

PI_NAMEs: MIELE, LUCIO  (contact)

PROJECT_TERMS: 2019-nCoV;Academic Medical Centers;Address;Alabama;All of Us Research Program;Applications Grants;Artificial Intelligence;Award;Awareness;biobank;Bioinformatics;biomedical informatics;Biomedical Research;career development;Center for Translational Science Activities;Centers of Research Excellence;citizen science;Clinic;Clinical;clinical center;Clinical Data;clinical database;Clinical Research;Clinical Sciences;Code;cohort;Collaborations;Communities;Correlation Studies;COVID-19;COVID-19 pandemic;Data;data enclave;data infrastructure;data pipeline;data resource;Data Science;Data Scientist;data sharing;Development;Drug Exposure;Education;epidemiology study;Funding;Geography;Goals;Grant;Health;Health Disparities Research;health disparity;High-Throughput Nucleotide Sequencing;Hospitals;Human Resources;improved;Informatics;informatics infrastructure;Infrastructure;Institution;inter-institutional;Louisiana;Machine Learning;machine learning algorithm;Master of Science;Measures;Medical;Mentorship;Mission;multidisciplinary;National Institute on Minority Health and Health Disparities;next generation;Obesity;Oncology;Outcome;Pilot Projects;Play;Population;Prevalence;programs;Publications;Research;Research Design;Research Personnel;Resolution;Resources;response;Role;rurality;SARS-CoV-2 antibody;SARS-CoV-2 variant;Seroprevalences;Services;social deprivation;Staging;Training;transcriptomics;translational pipeline;Translational Research;triple-negative invasive breast carcinoma;United States National Institutes of Health;Universities;Variant;Vertebral column;Viral;virtual;Virus;virus testing

PROJECT_TITLE: Core 06: Biomedical Informatics Core


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Networking and Information Technology R&D (NITRD);Prevention;Sexually Transmitted Infections;Social Determinants of Health;Stimulant Use and Misuse

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Narrative  The proposed research focuses on developing and prospectively testing the efficacy of a clinic-affiliated app (myCareLink) to deliver an integrated HIV prevention intervention in Malaysian MSM. We expect that this project will lead to the development of an innovative and culturally tailored app that will promote HIV testing and linkage to PrEP by addressing co-morbid psychiatric and substance use disorder (P/SUD) in Malaysian MSM.

PI_NAMEs: SHRESTHA, ROMAN  (contact)

PROGRAM_OFFICER_NAME: NEWSOME, BRAD

PROJECT_TERMS: Acceleration;Achievement;Acquired Immunodeficiency Syndrome;Address;Adherence;AIDS prevention;Amphetamines;Asia;Benchmarking;care systems;Caring;Cellular Phone;Client;Clinic;clinical care;cost effective;Counseling;Country;Decision Making;depressive symptoms;design;Development;Discrimination;Disparity;Drug usage;efficacy evaluation;efficacy outcomes;efficacy testing;Epidemic;evidence base;Face;Focus Groups;Fright;Guide prevention;Health;health care delivery;health disparity;health management;Health Personnel;Health Professional;Health Services;Healthcare;high risk;HIV;HIV Infections;Homosexuality;Human immunodeficiency virus test;Hybrids;implementation outcomes;Implementation readiness;implementation science;improved;Incidence;Income;innovation;insight;Institution;integrated care;interest;Interview;Laws;Learning;Link;low and middle-income countries;Malaysia;Malaysian;Measures;men;men who have sex with men;Mental Depression;Mental disorders;Mental Health;mHealth;mhealth interventions;mobile application;Modeling;mortality;Motivation;Muslim population group;Outcome;overtreatment;Patients;Persons;Phase;Population;pre-exposure prophylaxis;preference;Prevalence;Prevention;prevention practice;prevention service;preventive intervention;prospective test;prototype;Provider;provider communication;Psyche structure;psychiatric comorbidity;Psychoses;Recommendation;Research;research and development;Research Personnel;response;Risk Assessment;Risk Behaviors;scale up;screening;Services;sex;Sexual Health;Sexual Transmission;Sexuality;Sexually Transmitted Diseases;social stigma;southeast Asian;stakeholder perspectives;Statutes and Laws;Stigmatization;stimulant use;Strategic Planning;Study models;substance use;Substance Use Disorder;suicidal;syndemic;Technology;Testing;Translating;treatment as usual;Universities;Unsafe Sex;uptake;usability;virtual

PROJECT_TITLE: Development and Testing of a Mobile Application to Enhance HIV Prevention Cascade in Malaysian MSM


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Rural Health;Social Determinants of Health

PI_NAMEs: SHELLITO, JUDD E (contact)

PROJECT_TERMS: Academic Medical Centers;Agriculture;Behavioral;Center for Translational Science Activities;Chronic Disease;Clinical;clinical center;Clinical effectiveness;clinical infrastructure;Clinical Research;Clinical Sciences;clinical trial implementation;Clinical Trials;Clinical Trials Unit;Communities;community collaboration;community engagement;Community Networks;Community Outreach;COVID-19;COVID-19 pandemic;Data Collection;Dental Schools;Development;Devices;Diabetes Mellitus;Disease;Disparity population;Educational workshop;Ensure;Evaluation;Federally Qualified Health Center;Funding;Goals;Grant;Health;Hospitals;Human Resources;improved;Infrastructure;infrastructure development;Inpatients;Institution;Institutional Review Boards;intervention program;investigator training;Journals;lifestyle intervention;Location;Long COVID;Louisiana;Malignant Neoplasms;marginalization;Marketing;Medicine;member;Methods;Mission;New England;Obesity;operation;Outcome;Outpatients;participant retention;patient population;Persons;Pharmacologic Substance;Post-Acute Sequelae of SARS-CoV-2 Infection;Procedures;programs;Protocols documentation;Publishing;RADx Underserved Populations;recruit;Reduce health disparities;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;Rural;Rural Community;Rural Population;Schedule;Site;Source;support network;Testing;Training;Training Activity;Translational Research;translational research program;Translational trial;Underrepresented Populations;underserved community;Underserved Population;United States National Institutes of Health;vaccine hesitancy;Visit;web site

PROJECT_TITLE: Core 07: Clinical Research Resources Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Genetics;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

PHR: PROJECT NARRATIVE Many high-grade serous ovarian cancers originate from the fallopian tubes, from where the shedding of transformed fallopian tube secretory cells leads to metastasis. In this work, we will investigate if the fluidic environment around transformed fallopian tube cells has any roles in their release within the peritoneal organs. With the in vitro and in vivo models developed in our labs, we will establish the importance of shear stresses in the fluidic niches of fallopian tubes, that could be utilized in early detection of ovarian cancers.

PI_NAMEs: MEHTA, GEETA  (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: 3-Dimensional;Abdominal Cavity;Acceleration;Affect;Anatomy;Animal Model;Bioinformatics;Biological Assay;Biology;Biophysical Process;Bioreactors;BRCA1 gene;cancer cell;cancer diagnosis;cancer initiation;cancer therapy;Carcinoma;CDK4 gene;Cell Culture Techniques;Cell Death;cell growth;Cell Line;Cells;clinical diagnosis;clinical translation;Collagen;Custom;Cytoskeleton;Data;Death Rate;design and construction;Detection;Development;differential expression;Disease;Disease Progression;DNA Sequence Alteration;driver mutation;early detection biomarkers;Early Diagnosis;effective therapy;Environment;Epithelial Cells;Epithelium;Exposure to;F-Actin;fluid flow;gain of function;Genes;Genetic;genetic signature;Genetic Variation;Goals;Greater sac of peritoneum;Growth;Harvest;Human;Immune;Immune system;Immunocompetent;Immunocompromised Host;immunodeficiency;Immunodeficient Mouse;Immunotherapy;implantation;improved;In Vitro;in vivo;in vivo evaluation;in vivo Model;intraperitoneal;Intraperitoneal Injections;Invaded;Lesion;Link;Liquid substance;Location;loss of function;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Mammalian Oviducts;mechanical signal;mechanical stimulus;Mechanics;mechanotransduction;Microfluidic Microchips;Microfluidics;migration;Modeling;Molecular;Molecular Profiling;mouse model;Movement;Mus;Mutate;Mutation;Neoplasm Metastasis;neoplastic cell;novel;Omentum;Organ;Ovarian;Ovary;Pathway interactions;Patient-Focused Outcomes;Patients;Perfusion;Peritoneal;Peritoneum;Pharmaceutical Preparations;Play;Polysaccharides;Premalignant Cell;Prevention;Proliferating;Proteomics;Publishing;Randomized;RB1 gene;Recurrent disease;Regulation;Research;Role;Scaffolding Protein;screening;Screening for Ovarian Cancer;Secretory Cell;Sepharose;Serous;shear stress;Signal Pathway;Signal Transduction;Site;sobriety;Stage at Diagnosis;statistics;stem;stemness;Structure;subcutaneous;Surface;Survival Rate;Testing;TP53 gene;trait;transcriptome sequencing;Tube;tumor;Tumor Burden;tumor initiation;Validation;viscoelasticity;women's diagnosis;Work

PROJECT_TITLE: Profiling the Fluid Assisted Dissemination of Pre-malignant cells in Fallopian Tubes

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Hematology;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative Acute myeloid leukemia (AML) is an aggressive hematologic malignancy with no major progress in therapy in the past 20 years. The lack of specific targets, and an understanding of the molecular and cellular mechanisms of AML stem cells (AML-SC) restrict the development of treatments to improve the outcome. The proposed studies aim to identify the utility of DPP4 inhibitors (a useful type two diabetes medicine) in human AML treatment and to understand the role of DPP4 in the regulation of AML development.

PI_NAMEs: KANG, XUNLEI  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: 3-Dimensional;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Age;AML1-ETO fusion protein;Apoptosis;Binding;Biological Assay;Bone Marrow;cancer stem cell;cancer therapy;Cell Communication;cell growth;Cell surface;Cell Surface Proteins;Cell Transplantation;chemotherapy;Clinical;Colony-forming units;Colony-Forming Units Assay;comorbidity;Complete Blood Count;cytokine;Data;Databases;Development;Diagnosis;Dipeptidyl Peptidases;Disease;Engraftment;Exhibits;Extracellular Fluid;Feedback;Gene Expression;Goals;Growth;Hematologic Neoplasms;high resolution imaging;Human;imaging study;improved;improved outcome;in silico;In Vitro;in vivo;inhibitor;Investigation;knock-down;Knock-out;leukemia;leukemia treatment;leukemic stem cell;Malignant Neoplasms;Mediating;Medicine;Membrane Proteins;Methods;migration;MLL-AF9;Molecular;mortality;mouse model;Mus;Myelosuppression;NF-kappa B;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;p65;Patients;Peripheral;Persons;Play;prevent;Proteins;Regulation;Relapse;Research;restoration;restraint;Role;self-renewal;Serum;Signal Transduction;small hairpin RNA;src-Family Kinases;standard care;stem cell survival;Stromal Cells;Survival Rate;Testing;therapy development;trafficking;transcriptome sequencing;Treatment Protocols;Tumor Burden;United States;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Membrane protein target for leukemia therapy

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Gene Therapy;Genetics;Immunization;Infectious Diseases;Influenza;Lung;Nanotechnology;Pneumonia and Influenza;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Vaccine Related

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE This research will develop scalable and cost-effective gene therapy to elicit directed immunity against pathogenic respiratory infections which impact tens of millions of patients worldwide. We are proposing to use gold nanoparticles to deliver precise genetic insertion of protective monoclonal antibodies against viral pathogens in immune cells and repopulating hematopoietic stem and progenitor cells. This single step approach combines the latest CRISPR delivery technology with a new strategy to direct adaptive immunity to pathogenic infections for which standard vaccination approaches have had limited to no success.

PI_NAMEs: ADAIR, JENNIFER EILEEN (contact);TAYLOR, JUSTIN J

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: adaptive immunity;Aftercare;Antibodies;Antibody Formation;Antibody Response;Antibody titer measurement;Antigens;B-Cell Activation;B-Lymphocyte Subsets;B-Lymphocytes;Blood Cells;cell type;Cells;cellular engineering;Cessation of life;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Coronavirus;cost effective;Country;Coupled;COVID-19 pandemic;cytotoxicity;Development;efficacy evaluation;engineered stem cells;Engineering;Ensure;Equity;Formulation;Gene Delivery;gene therapy;gene-editing approach;Genes;Genetic;Genetic Engineering;genetically modified cells;genomic locus;Health;Hematopoietic stem cells;HIV;Hospitalization;Human;Immune;Immune response;Immunity;Immunology;in vivo;in vivo evaluation;Individual;Infection;Influenza;influenza virus strain;Injections;Laboratories;Leukocytes;Maintenance;manufacture;Mediating;Memory;Memory B-Lymphocyte;Monoclonal Antibodies;mortality;mouse model;Mus;nanoformulation;nanoGold;nanoparticle;Nature;neutralizing antibody;novel;novel strategies;pathogenic virus;Pathogenicity;Patients;peripheral blood;Plasma;Plasma Cells;prevent;Process;Production;promoter;Property;Provider;Publications;rational design;Research;Resources;respiratory;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Respiratory Tract Infections;respiratory virus;response;Role;safety and feasibility;Science;selective expression;Serum;Single-Stranded DNA;Societies;Source;success;synergism;System;targeted delivery;Technology;Testing;therapeutic genome editing;Time;Tissues;tool;Toxic effect;United States;Vaccination;vaccine strategy;Vaccines;Viral;Viral Respiratory Tract Infection;Virus;Virus Diseases;Visit;Work;World Health Organization

PROJECT_TITLE: Targeted genetic engineering of B cells to induce protective antibody responses to viral pathogens

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;HPV and/or Cervical Cancer Vaccines;Health Services;Immunization;Infectious Diseases;Pediatric;Prevention;Primary Health Care;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: Project Narrative Millions of US teens remain at risk of developing human papillomavirus (HPV)-related cancers due to inadequate HPV vaccine uptake despite strong endorsement in clinical guidelines; yet intervention studies have not fully addressed the multilevel, multi-factorial and heterogeneous barriers to HPV vaccination improvement. We propose an innovative 3-arm cluster randomized controlled trial to compare the effectiveness of a local-tailored strategy that allows local tailoring of multilevel, multi-component interventions based on local barriers and context, versus a prescribed strategy that pre-specifies the multilevel, multi-component interventions that are fixed across sites, versus usual care. This study will be conducted in one of the largest community-based pediatric care organizations in the US and has high potential to provide much needed guidance on strategies for optimizing HPV vaccination in diverse health care settings.

PI_NAMEs: CHAO, CHUN R. (contact);HAHN, ERIN ELIZABETH

PROGRAM_OFFICER_NAME: CHOLLETTE, VERONICA

PROJECT_TERMS: Address;Advisory Committees;Affect;Age;arm;California;cancer care;Caring;Child health care;Childhood;Clinic;Clinical;Cluster randomized trial;Communication;Communities;community setting;compare effectiveness;Consolidated Framework for Implementation Research;Continuity of Patient Care;cost effectiveness;Cost Effectiveness Analysis;Data;design;effective intervention;Effectiveness;effectiveness evaluation;Electronic Health Record;Environment;Family;Guidelines;health care settings;Health Personnel;Health system;Healthy People 2020;Heterogeneity;HPV vaccine acceptance;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Immunization;implementation framework;implementation science;implementation strategy;improved;innovation;insight;Intervention;intervention refinement;Intervention Studies;Interview;Intuition;Investments;Knowledge;Measures;Mediation;Methods;multi-component intervention;Nature;novel;Office Visits;Outcome;Parenting Education;Parents;Patients;Perception;practice setting;preadolescence;primary outcome;process evaluation;programs;Provider;Public Health;Randomized, Controlled Trials;Recommendation;Research;Resources;response;Risk;secondary outcome;Series;Site;Specific qualifier value;Subgroup;success;Support System;Surveys;Teenagers;Testing;Thinking;Training;treatment as usual;Vaccination;vaccine acceptance;Variant;Work

PROJECT_TITLE: Effectiveness and Mechanisms of Multilevel Implementation Strategies to Improve Provider Recommendation and Advance HPV Vaccination: a Cluster Randomized Trial

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ORG_CITY: INDIANAPOLIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Destruction of the insulin-producing beta cell is the underlying cause of nearly all forms of diabetes. To develop new cellular or regenerative therapies to prevent or treat diabetes, the mechanisms and factors necessary to expand beta cell mass must be defined. We have discovered hypusine biosynthesis to be required for exocrine pancreas development and beta cell growth, and using novel mouse models and human tissues we will bring to light unrecognized mechanisms that expand beta cell mass, which may be exploitable for diabetes therapeutic development.

PI_NAMEs: MASTRACCI, TERESA LOUISE (contact)

PROGRAM_OFFICER_NAME: ZAGHLOUL, NORANN

PROJECT_TERMS: Ablation;Acinar Cell;Adult;Affect;Alleles;Amino Acids;Anabolism;Area;Beta Cell;Biology;Blood Glucose;cell growth;Cell Physiology;Cell Proliferation;cell regeneration;Cell Therapy;Cells;Cellular Stress;chronic pancreatitis;Cre driver;Cystic Fibrosis;Data;deoxyhypusine synthase;Development;Diabetes Mellitus;Diabetic mouse;Diet;Digestion;Diphtheria Toxin;Disease;Drug Targeting;eIF-5A;Embryo;Endocrine;enzyme deficiency;Enzyme Inhibitor Drugs;Enzymes;Eukaryotic Cell;Eukaryotic Initiation Factors;Exocrine pancreas;Functional disorder;Genes;Goals;Growth;Hormones;Human;human tissue;hypusine;in vivo;Incidence;Individual;inducible Cre;Insulin;Insulin-Dependent Diabetes Mellitus;interest;islet;Islet Cell;islet stem cells;Islets of Langerhans;Knockout Mice;Link;Lysine;Mass Spectrum Analysis;Metabolic;Metabolic dysfunction;Metabolism;Modeling;Molecular;mouse model;mRNA Translation;Mus;mutant;mutant mouse model;Natural regeneration;novel;novel therapeutics;Organ;Outcome;Pancreas;pancreas development;Pancreatic enzyme;Pathway interactions;Post-Translational Protein Processing;postnatal;preservation;prevent;Protein Biosynthesis;Proteins;Publishing;regenerative therapy;Reporting;Research;Role;Signal Transduction;Tamoxifen;Testing;therapeutic development;Tissues;tool;translation factor;translational impact;Translations;Weaning;Work

PROJECT_TITLE: Exocrine-Endocrine Crosstalk and Determinants of Beta Cell Growth

STUDY_SECTION: CADO

STUDY_SECTION_NAME: Cellular Aspects of Diabetes and Obesity Study Section[CADO]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Nutrition;Obesity;Pediatric;Physical Activity;Prevention

ORG_CITY: PROVIDENCE

ORG_NAME: MIRIAM HOSPITAL

ORG_STATE: RI

PHR: Project Narrative This project seeks to improve weight management outcomes among adolescents with obesity by enhancing adolescent emotion regulation skills and improving dietary and physical activity behaviors.

PI_NAMEs: HADLEY, WENDY S;JELALIAN, ELISSA  (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: 15 year old;17 year old;19 year old;Address;Adolescence;Adolescent;adolescent mental health;Adolescent obesity;Adult;Age;Attention;Behavior;Behavior Control;Behavior Therapy;behavioral construct;Behavioral Weight Control;Body mass index;Body Weight decreased;Chronic;control trial;Data;Development;diabetes control;Dialectical behavior therapy;Diet;dietary;distress tolerance;Eating;efficacious intervention;efficacy evaluation;emotion dysregulation;emotion regulation;Emotional;emotional eating;Energy consumption;Enrollment;executive function;Failure;Feeling;Food;food consumption;Goals;Health;high body mass index;Hour;improved;innovation;Intervention;intervention effect;Laboratories;Maintenance;meetings;Mental Health;mindfulness;moderate-to-vigorous physical activity;multi-site trial;negative affect;Nutrient;Obesity;obesity in children;obesity treatment;Outcome;Outpatients;Overweight;Participant;Pediatric Hospitals;peer;Physical activity;Pilot Projects;pilot trial;Prevalence;Prevention;Process;programs;Randomized;Randomized, Controlled Trials;rapid weight gain;Reporting;response;Sampling;sedentary;sedentary lifestyle;sex;Site;skills;skills training;Symptoms;Teenagers;Testing;Time;Treatment Efficacy;Weight;Weight maintenance regimen;Work;Youth

PROJECT_TITLE: Enhancing Emotion Regulation to Support Weight Control Efforts in Adolescents with Overweight and Obesity

STUDY_SECTION: PRDP

STUDY_SECTION_NAME: Psychosocial Risk and Disease Prevention Study Section[PRDP]


NIH_SPENDING_CATS: Aging;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Digestive Diseases;Nutrition;Orphan Drug;Pain Research;Pancreatic Cancer;Patient Safety;Precision Medicine;Prevention;Rare Diseases;Sarcopenia

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Diabetes mellitus is a risk factor for pancreatitis and pancreatic cancer, as well as a consequence and complicating illness for both diseases. The ongoing work of the CPDPC aims for improving outcomes in these related and difficult to treat conditions, through earlier and more accurate diagnosis, more effective therapeutic options, and ultimately personalized approaches informed by more mechanistic understanding. The University of Florida will contribute to the ongoing work of the CPDPC consortium studying these disease relationships, by participating as a high volume center contributing to the ongoing patient cohorts and patient biological samples, as well as proposing and supporting future studies using the platform of the CPDPC for identifying accurate biomarkers and more effective therapies.

PI_NAMEs: CUSI, KENNETH ;FORSMARK, CHRISTOPHER E (contact);HUGHES, STEVEN J

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: accurate diagnosis;Acute;acute pancreatitis;Adopted;Affect;Anatomy;Area;Biological;Biological Markers;biomarker development;biomarker validation;Cancer Patient;central sensitization;Chronic;chronic pain;chronic pancreatitis;Clinical;Clinical Cancer Center;clinical center;Clinical Data;Clinical Research;Clinical Trials;clinically relevant;cohort;common symptom;Complex;Continuous Glucose Monitor;Cross-Sectional Studies;Data;Development;Devices;Diabetes Mellitus;diabetes mellitus therapy;Disease;Drainage procedure;drug development;drug repurposing;Early Diagnosis;effective intervention;effective therapy;Eligibility Determination;Excision;Exocrine pancreatic insufficiency;Florida;follow-up;Future;Glucose;glycemic control;Goals;health organization;Health system;high risk;Hormones;Hypoglycemia;Image;improved;improved outcome;Individual;individual patient;Insulin;Insulin deficiency;Insulin Resistance;Intervention;Intervention Trial;Islet Cell;Islets of Langerhans;Knowledge;Malignant neoplasm of pancreas;Malnutrition;Measures;Medical;member;metabolic profile;Morbidity - disease rate;mortality;novel marker;nutrient absorption;Operative Surgical Procedures;Opiate Addiction;Opioid;Outcome;Pain;Pancreas;Pancreatic Diseases;Pancreatitis;Patients;personalized approach;personalized screening;Phase;precision medicine;Precision therapeutics;Prevalence;prevent;Prevention;Prognosis;Protocols documentation;Quality of life;recruit;Relapse;Research;Resources;response;Risk;Risk Factors;risk stratification;Role;Sampling;sarcopenia;Study Subject;surgery outcome;Technology;Testing;Therapeutic;Therapeutic Intervention;Therapeutic Trials;therapeutically effective;treatment risk;trial comparing;Universities;Work

PROJECT_TITLE: U-01 CONSORTIUM FOR THE STUDY OF CHRONIC PANCREATITIS,DIABETES AND PANCREATIC CANCER CLINICAL CENTERS


ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: OMAHA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative: This interdisciplinary training program is designed to train the next generation of scientists and clinicians to gain the knowledge and support necessary to tackle the complexities presented by Alzheimer’s Disease (AD) and Related Dementias (ADRD). The mission of this training program is to address the critical need to connect the current disparities between significant scientific advances in the science and treatment of AD and the implementation of drug design and discovery for human trials. Students who graduate this program will examine critical hypotheses regarding the etiology, pathophysiology, and effective drug therapies for those diagnosed with ADRD and other neurodegenerative disorder

PI_NAMEs: FOX, HOWARD S;TRIPPIER, PAUL  (contact)

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: Alzheimer's disease related dementia;drug discovery;Training Programs

PROJECT_TITLE: UNMC Training Program in Alzheimer’s Disease and Related Dementias Drug Discovery


NIH_SPENDING_CATS: Cancer

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: PROJECT NARRATIVE BCL-2 family proteins are master arbiters of mitochondrial apoptosis and deregulation of their protein interaction mechanisms contributes to the development, maintenance, and chemoresistance of human cancer. The overarching goal of this R35 research program is to develop unique chemical probes and apply the latest analytical technologies to tackle longstanding enigmas of the apoptotic pathway, including how death proteins self-associate to permeabilize the mitochondria, novel modes of post-translational BCL-2 family regulation, and unanticipated interaction partners that integrate apoptosis with critical cellular signaling pathways. By revealing new apoptotic mechanisms, targets, and binding surfaces, our studies not only inform fundamental cancer biology but also provide next-generation treatments for reactivating apoptosis in human cancer.

PI_NAMEs: WALENSKY, LOREN DAVID (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Advanced Development;Apoptosis;Apoptotic;BAX gene;BCL-2 Protein;BCL1 Oncogene;BCL2 gene;Binding;Binding Sites;Biochemistry;Cancer Biology;cancer therapy;Cells;Cellular biology;Cessation of life;Chemicals;Chemistry;Chemoresistance;Cysteine;Development;Enzymes;Family;fatty acid metabolism;fatty acid oxidation;Goals;Human;in vivo evaluation;inhibitor;insight;interdisciplinary approach;Length;Ligands;Long-Chain-Acyl-CoA Dehydrogenase;Maintenance;Malignant Neoplasms;MCL1 gene;Mediating;Metabolic;Mitochondria;Modification;Molecular;Molecular Conformation;monomer;mutant;next generation;novel;novel therapeutics;Pathogenesis;Pathologic;Pathway interactions;Pediatric Oncologist;Permeability;pharmacologic;Phase;Post-Translational Protein Processing;programs;Protein Family;Proteins;Proteomics;prototype;refractory cancer;Regulation;Relapse;Research;Resistance;Role;Signal Pathway;structural biology;structural determinants;Structure;Surface;Technology;tool;tumor metabolism;Work

PROJECT_TITLE: Dissecting and Targeting Deregulated Mitochondrial Apoptosis in Human Cancer


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Genetics;Infectious Diseases;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE More than 12,000 women are diagnosed with cervical cancer annually in the U.S. Although squamous cell cancer of the cervix can be prevented through cervical screening programs, adenocarcinoma of the cervix cannot. This project will evaluate molecular markers that may identify precursors of adenocarcinoma of the cervix that will facilitate prevention through new screening strategies.

PI_NAMEs: BURK, ROBERT D (contact);STRICKLER, HOWARD D

PROGRAM_OFFICER_NAME: STARKS, VAURICE

PROJECT_TERMS: Adenocarcinoma;Adenocarcinoma In Situ;Age;Area Under Curve;Automobile Driving;Biological Assay;Biology;Biopsy;California;cancer cell;Cancer Etiology;cancer invasiveness;carcinogenesis;cell dedifferentiation;Cells;Cervical;Cervical Adenocarcinoma;Cervical Cancer Screening;Cervical Intraepithelial Neoplasia;Clinical;clinical application;Clone Cells;cohort;Colposcopy;comparison control;cost;cost effective;Cytology;Data;Detection;Developed Countries;Development;Diagnosis;DNA;Epigenetic Process;Europe;Evaluation;Evolution;Exposure to;Frequencies;gene panel;Generations;Genes;Genome;Genotype;Goals;High Risk Woman;Histologic;HPV vaccine acceptance;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16;Human papillomavirus 18;In Situ Lesion;Infection;Infection Control;integration site;Investigation;Lesion;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Malignant Squamous Cell Neoplasm;Measures;Methylation;Modeling;Molecular;molecular marker;Natural History;Natural Selections;Neoplasms;next generation sequencing;Oncogenes;Oncogenic;Pathogenesis;premalignant;prevent;Prevention;Preventive vaccine;Process;prophylactic;prospective;Public Health;Reporting;Risk;risk prediction model;Sample Size;Sampling;screening;screening program;Specimen;Squamous cell carcinoma;Technology;Testing;Vaccines;Viral;Viral Genome;virtual;Virus Integration;Woman;women's diagnosis

PROJECT_TITLE: Investigations Into The Molecular Pathogenesis Of Cervical Glandular Neoplasias

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Immunotherapy;Infectious Diseases

ORG_CITY: CAMBRIDGE

ORG_NAME: ADA FORSYTH INSTITUTE, INC.

PHR: PROJECT NARRATIVE Periodontitis is characterized by episodic recurrence throughout the patient's life, a growing global public health problem due to its bidirectional association with general health. This project will identify the generation, persistence, and pathogenic role of periodontitis-induced CD4+ memory T cell subtypes in a model of recurring periodontal disease. Using a novel T cell periodontal enriching strategy, we will dissect the functional properties of constitutively versus pathologically developed CD4+ memory T cells and assess the therapeutic potential of targeting these cells to prevent periodontitis recurrence.

PI_NAMEs: ALVAREZ RIVAS, CARLA  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acceleration;Acute;Adult;Alveolar Bone Loss;Antigens;Apoptosis;Award;Bacteria;Biological Assay;Birth;bone;bone loss;career;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Compartmentation;cell type;Cells;Cervical lymph node group;checkpoint inhibition;Chronic Disease;chronic inflammatory disease;Clinical;clinically relevant;Complex;Data;Development;Disease;disease model;Disease Progression;Down-Regulation;effector T cell;Fostering;Future;Generations;germ free condition;Germ-Free;Gingiva;Goals;Growth;Health;Health Transition;healthy aging;Human;Immune;Immunologics;Immunology;in vivo Model;Inflammation;Inflammatory;inflammatory bone loss;Intervention;Knowledge;Life;Ligature;Link;Literature;lymph nodes;Memory;memory CD4 T lymphocyte;Metabolic;Methods;microbial;microbial colonization;microorganism antigen;Modeling;mouse model;Mucous Membrane;Mus;National Institute of Dental and Craniofacial Research;novel;Oral;Oral Characters;oral microbiome;Pathogenicity;Pathologic;Patients;Periodontal Diseases;Periodontitis;Phase;Phenotype;Population;Postdoctoral Fellow;Pre-Clinical Model;prevent;Process;Productivity;programs;Property;Public Health;Recurrence;Recurrent disease;Regulatory T-Lymphocyte;Relapse;Research;Research Personnel;Resolution;response;Role;spatiotemporal;T cell infiltration;T memory cell;T-Lymphocyte;Testing;Therapeutic;therapeutic target;Time;Tissue Expansion;Tissues;Tooth Loss;transcriptomics;translational scientist;translational study

PROJECT_TITLE: The Role of CD4+ Memory T cell Subtypes in Periodontal Disease Recurrence

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Aging;Social Determinants of Health

ORG_NAME: NATIONAL BUREAU OF ECONOMIC RESEARCH

PHR: OTHER PROJECT INFORMATION – Project Narrative The NBER Training Program in Aging and Health Economics will offer pre- and post-doctoral research fellowships in the economics of aging and health care. The goal is to provide a strong research background to a new generation of emerging scholars in economics who will contribute to our understanding of health trends and disparities, the dynamics of the health care ecosystem, and approaches to improving health outcomes for an aging population.

PI_NAMEs: CUTLER, DAVID M;FINKELSTEIN, AMY N. (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY