ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Physical Injury - Accidents and Adverse Effects;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE The proposed study will be the first to quantitatively investigate the demand for, barriers to, and preferences for health services among sexual violence (SV) survivors. Study findings can inform interventions that facilitate health service utilization among victims of SV in low-income countries (LICs) like Uganda, ultimately improving the overall reproductive health, mental health, and related health outcomes for women in communities where rates of SV are high. Lessons learned from public health efforts in LICs, such as Uganda, may be relevant to improving overall care for vulnerable populations, such as women experiencing sexual violence, in high- income countries, including the United States where utilization of sexual violence health services remains low.

PI_NAMEs: MUTUMBA, MASSY ;SSEWAMALA, FRED M;STARK, LINDSAY B (contact)

PROGRAM_OFFICER_NAME: CAMPBELL-ROSEN, HOLLY RENEE

PROJECT_TERMS: Address;Africa South of the Sahara;Age;Alcohol consumption;Behavior;Behavioral Model;care seeking;Caring;Child;Chronic stress;Communities;community building;Country;Decision Making;design;Development;Drug usage;Economic Development;Economic Factors;Economics;Education;effective intervention;effective therapy;emergency contraception;Emergency treatment;Ensure;experience;experimental study;Exposure to;Female;Financial cost;follow-up;Forcible intercourse;Fright;Future;global health;Goals;Health;Health care facility;health service use;Health Services;Health Services Accessibility;HIV;improved;Income;Individual;Injury;innovation;Intervention;Interview;Investments;Knowledge;Language;Lead;Life;low income country;Marital Status;medical supply;Mental Depression;Mental Health;Methodology;Methods;National Institute of Mental Health;Outcome;Perception;Phase;physical conditioning;Population;preference;Process;Prophylactic treatment;psychologic;Public Health;Qualifying;Qualitative Research;Recommendation;recruit;Reporting;reproductive;Reproductive Health;Research;Research Personnel;Resources;Risk Behaviors;Safety;self esteem;service uptake;Services;sexual coercion;sexual risk taking;sexual violence;Sexually Transmitted Diseases;Social Development;Social Network;social norm;social stigma;sociodemographic variables;Structure;Survivors;Testing;therapy design;Trauma;Trust;Uganda;United States;United States National Institutes of Health;Unwanted pregnancy;uptake;user centered design;Utility Theories;Violence;violence victimization;Visit;Vulnerable Populations;Woman;Women's Health;women's outcomes

PROJECT_TITLE: Obuvumu: Improving Health Service Uptake for Survivors of Sexual Violence

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Contraception/Reproduction;HIV/AIDS;Infectious Diseases;Prevention;Sexually Transmitted Infections;Topical Microbicides;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_FIPS: US

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: RELEVANCE TO PUBLIC HEALTH The benefit of multipurpose prophylaxis to women with high risk of HIV/STIs infection is significant. Long-acting intravaginal formulations providing steady release over weeks or months of antiretroviral drugs in combination with a contraceptive drug can potentially increase compliance to STIs and unintended pregnancy prophylactic regimen and transform the HIV prevention landscape. The overarching goal of this proposal is to develop and evaluate an innovative approach to multipurpose intravaginal rings that can contribute to curb the HIV epidemic.

PI_NAMEs: BENHABBOUR, SOUMYA RAHIMA (contact)

PROGRAM_OFFICER_NAME: PORTER, KRISTEN AMY

PROJECT_TERMS: 3-Dimensional;3D Print;Acceleration;Address;Adherence;Affinity;AIDS prevention;Anatomy;Animal Model;Anti-Retroviral Agents;Behavioral;Biological;Cervical;Characteristics;Clip;Complex;Contraceptive Agents;Contraceptive methods;contraceptive microbicide;controlled release;cost effective;Dapivirine;Data;design;Development;Development Plans;Device Designs;Device Removal;Devices;Diffusion;Drug Delivery Systems;Drug Kinetics;drug release kinetics;Effectiveness;efficacy evaluation;Engineering;Epidemic;Epidemiology;Ethinyl Estradiol;Etonogestrel;Evaluation;Excision;experience;Female;Formulation;Fostering;Geometry;Goals;Grant;Health Benefit;high risk;Histology;HIV;HIV/STD;Hormone replacement therapy;Human Herpesvirus 2;Human Papillomavirus;implementation design;improved;In Vitro;in vitro Assay;in vivo;Infection;Injections;innovation;Link;Liquid substance;Macaca;manufacture;manufacturing technology;Measures;mechanical properties;Methodology;Methods;microbicide;Molds;multidisciplinary;next generation;nonhuman primate;older women;Patients;Pattern;Perception;Performance;Permeability;Persons;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;pharmacologic;Physiology;Plasma;Population Heterogeneity;pre-clinical;preference;prevent;Prevention;Process;Production;Property;prophylactic;Prophylactic treatment;prototype;Public Health;quality assurance;Recording of previous events;Regimen;Safety;safety assessment;Sensory;sex;Sheep;simian human immunodeficiency virus;sound;Steroids;success;Surface Properties;System;Tail;Technology;Testing;Time;Tissues;tool;transmission process;unintended pregnancy;User Compliance;Vagina;vaginal microbicide;vaginal microbiome;Vaginal Ring;Viral;willingness;Woman;young woman

PROJECT_TITLE: Next Generation Multipurpose Intravaginal Ring Technology Using Innovative CLIP 3D Printing


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: MADISON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE The studies proposed in this application will provide critical information regarding fusion pore formation and exocytosis, which play a key role in neurological, mental, and endocrine function. The proposed research will significantly advance our understanding of hormone and neurotransmitter release. This will, in turn, aid in efforts to alter hormone and neurotransmitter release in disease states in which too much, or too little, release occurs.

PI_NAMEs: CHAPMAN, EDWIN R (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TITLE: Structure and dynamics of exocytotic fusion pores


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The goals of our research are to identify and characterize the molecular machinery that contributes to synaptic signaling in the nervous system, with a focus on signaling mediated by the excitatory neurotransmitter glutamate and the NMDA-subtype of postsynaptic ionotropic glutamate receptors. Our goal is to obtain a mechanistic understanding of how the function of NMDARs is regulated by the presynaptically released auxiliary protein, NRAP-1. These studies will help direct efforts for new drug targets, and ultimately contribute to the development of new therapeutic modalities for the treatment of neurological and psychiatric disorders.

PI_NAMEs: MARICQ, ANDRES VILLU (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Active Biological Transport;Amino Acids;Behavior;Binding;Biological Models;Caenorhabditis elegans;Cell model;chemical genetics;Chimera organism;Clinical;Data;Development;Disease;Drosophila genus;Exhibits;experimental study;Genes;Genetic;Genetic Screening;Genetic Techniques;Glutamate Receptor;Glutamates;Goals;Homologous Gene;in vivo;insight;Invertebrates;Kinetics;Learning;Long-Term Potentiation;Maps;Mediating;Memory;Mental Depression;Mental disorders;Mental Health;Modality;Modeling;Molecular;Molecular Motors;Mutation;N-Methylaspartate;Nervous System;Nervous System Disorder;neural;neural circuit;Neurodegenerative Disorders;Neurons;Neurophysiology - biologic function;Neurotransmitters;new therapeutic target;novel;novel therapeutics;optogenetics;overexpression;postsynaptic;presynaptic;Process;protein protein interaction;Proteins;receptor;Recombinants;Regulation;Research;Resolution;Role;Scaffolding Protein;Schizophrenia;Signal Transduction;Site;Structure;Synapses;synaptic function;Synaptic plasticity;Testing;Transgenic Organisms;Work

PROJECT_TITLE: Regulation of NMDAR-Mediated Synaptic Signaling


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Brain Disorders;Childhood Obesity;Clinical Research;Multiple Sclerosis;Neurodegenerative;Neurosciences;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Multiple sclerosis (MS) is an immune-mediated, neurodegenerative disorder that can affect children and results in progressive brain volume loss over time. Obesity is highly associated with progressive brain atrophy in people without MS. While early-life obesity is known to be a risk factor for developing MS, obesity’s impact on MS disease severity and course is unknown; thus, this proposal seeks to define the relationship between obesity, inflammatory disease activity, and neurodegeneration in children with MS.

PI_NAMEs: BRENTON, JAMES NICHOLAS (contact)

PROGRAM_OFFICER_NAME: HARTMAN, ADAM L

PROJECT_TERMS: Acceleration;Adipocytes;adipokines;adiponectin;Adipose tissue;Adolescence;Adult;Affect;Age;Animal Model;Atrophic;Award;Biological;Biological Markers;Body mass index;Brain;brain volume;career development;Categories;cell injury;Central Nervous System;cerebral atrophy;Child;Childhood;Clinical;Clinical Research;CNS autoimmune disease;cohort;Cohort Studies;Conduct Clinical Trials;Cross-Sectional Studies;cytokine;Data;Data Set;Demyelinations;design;Development;Development Plans;Diagnosis;disability;Disease;Disease Progression;Epidemic;Exhibits;experience;Failure;Fasting;Funding;Future;Goals;gray matter;Growth;Health;Image;Immune;Immune response;Immune system;immunoregulation;Immunotherapy;Inflammation;Inflammatory;Injury;International;Intervention Studies;Leptin;Lesion;Life;Light;Link;Longitudinal cohort study;Magnetic Resonance Imaging;Measures;Mediating;Mentors;Modeling;modifiable risk;Modification;Molecular Weight;Multi-site clinical study;Multiple Sclerosis;Nerve Degeneration;Neurocognitive;Neurodegenerative Disorders;neurofilament;neuroimaging;Neurological disability;Neurologist;Neurons;Non obese;novel;Obesity;obesity in children;Only Child;Outcome;Overweight;overweight child;Patients;Pediatric Hospitals;pediatric multiple sclerosis;pediatric patients;Persons;Philadelphia;Prospective Studies;Protein Isoforms;Publishing;Radiology Specialty;recruit;repository;Research;Research Methodology;Research Personnel;Risk;Risk Factors;Role;Sampling;Science;Scientist;Serology;Serum;Severities;Severity of illness;sex;Techniques;Therapeutic;Time;tool;Training;United States National Institutes of Health;Weight;Work;young adult

PROJECT_TITLE: Obesity as a Driver of Inflammation and Brain Volume Loss in Pediatric Multiple Sclerosis

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Regenerative Medicine;Rehabilitation;Spinal Cord Injury;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Transplantation;Traumatic Head and Spine Injury

ORG_CITY: COLLEGE STATION

ORG_DEPT: BIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY

ORG_STATE: TX

PHR: Spinal cord injury causes lifelong paralysis due to the permanent loss of spinal cord neurons that relay motor (movement) commands from the brain to the body. We can provide new neurons to the injured spinal cord by transplanting neural progenitor cells; however, it is not clear how these cells can support recovery of motor function. We will examine how transplanted neurons connect with motor control centers in the brain, test their ability to elicit activity in the muscles in the arm, and examine whether cell transplantation combined with rehabilitation therapy can promote greater recovery of hand function following spinal cord injury.

PI_NAMEs: DULIN, JENNIFER N (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acceleration;Acute;Address;Anatomy;Animals;arm;axon regeneration;Biological;Brain;Cell Differentiation process;Cell Transplantation;Cells;Central Nervous System;Cervical spinal cord injury;Cervical spinal cord structure;Chronic;Clinical Treatment;Complex;Development;Dorsal;effective therapy;Electrophysiology (science);Engraftment;Experimental Designs;Forelimb;Foundations;functional outcomes;functional restoration;Genetic;hand dysfunction;Hand functions;hand rehabilitation;Human;improved;Individual;injured;Injury;Interneurons;Knowledge;Mediating;Modeling;Motor;motor control;motor function recovery;mouse model;Movement;Muscle;Natural regeneration;nerve stem cell;Nervous System;Nervous System Physiology;Nervous System Trauma;neural;neural circuit;neural graft;Neurological outcome;Neurons;neurotransmission;Outcome;Paralysed;Phenotype;pre-clinical;Quality of life;Recovery;Recovery of Function;Recovery Support;Rehabilitation therapy;Reporting;Reproducibility;Research;Respiratory Diaphragm;response;Role;Site;skills;Spinal Cord;Spinal cord injury;Stem cell transplant;Synapses;synaptogenesis;Testing;Therapeutic;therapeutically effective;Time;Training;Transplantation;transplantation therapy;Work

PROJECT_TITLE: Dissecting Connectivity and Function of Transplanted Interneurons in the Injured Spinal Cord

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Prevention;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Inherited retinal diseases that lead to devastating blinding conditions were previously considered incurable, but a handful of them can now be treated with emerging new gene therapy options. However, before potential therapies can be made available for patients, it is critical that they are tested for effectiveness and evaluated for safety in appropriate clinically-relevant model systems. The research proposal aims to understand the mechanisms of genetic mutations causing retinal diseases, and to establish preclinical proof-of-principle by developing and testing new therapies that prevent or delay the retinal degeneration that leads to blindness.

PI_NAMEs: AGUIRRE, GUSTAVO DAVID (contact);BELTRAN, WILLIAM A.

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Acceleration;Address;Affect;Age;Animal Diseases;Animal Model;Biological;Biological Models;Blindness;Breeding;canine model;Canis familiaris;cell type;Cells;Cellular biology;Clinical;Clinical Trials;clinically relevant;Collaborations;combinatorial;cone-rod dystrophy;cost effective;Data;design;Development;Disease;disease model;disorder prevention;DNA Sequence Alteration;effective therapy;effectiveness testing;efficacy testing;Ensure;experience;Fostering;Funding;Future;gene augmentation therapy;gene complementation;gene replacement therapy;gene therapy;Genes;Genetic;Genotype;Goals;Grant;Health;Human;human disease;Inflammation;Inherited;Investigation;Leber's amaurosis;Macrophage;man;Marketing;Methods;Microglia;Modeling;Molecular;Monitor;mutant;Mutation;neuroprotection;Night Blindness;novel therapeutic intervention;novel therapeutics;Ophthalmology;Outcome;Outcome Measure;Pathogenesis;Pathogenicity;Patients;Pennsylvania;Peptide Hydrolases;Persons;Phenotype;photoreceptor degeneration;Photoreceptors;pre-clinical;preclinical evaluation;predicting response;prevent;Prevention;Process;Productivity;programs;Progress Reports;reproductive;Research;research facility;Research Personnel;Research Proposals;research study;Resources;response;Retina;Retinal Degeneration;Retinal Diseases;Retinitis Pigmentosa;Role;RPE65 protein;RPGR gene;Safety;Series;Site;sound;Structure of retinal pigment epithelium;success;targeted treatment;Testing;Therapeutic Studies;therapeutic target;therapy outcome;translational study;treatment response;U-Series Cooperative Agreements;United States National Institutes of Health;Universities;vector;Visual;Vitelliform macular dystrophy

PROJECT_TITLE: Models for Therapy of Hereditary Retinal Degeneration

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: The first four years immediately following separation from military service is a high-risk period for suicide among Veterans. During this time, as Veterans are reintegrating into civilian life, they face a number of health- and functioning-related challenges, which can be categorized into six key domains. However, very little work has investigated how the process of negotiating reintegration challenges affects suicide risk among reintegrating Veterans over time, and which subgroups of Veterans may be most vulnerable to developing suicide risk. Importantly, surveillance data and prior research suggests that women and men experience this reintegration period differently, but not enough is known to tailor prevention strategies for women in this population. The proposed national cohort study of reintegrating Veterans will gather critically needed data to inform gender-tailored suicide prevention efforts and direct valuable resources across the six domains of functioning to subgroups of reintegrating Veterans most at risk of suicide.

PI_NAMEs: DENNESON, LAUREN M (contact)

PROJECT_TERMS: Affect;Area;base;Baseline Surveys;Categories;Classification;Cognition;cohort;Cohort Studies;Cross-Sectional Studies;Data;data repository;Data Set;Department of Defense;design;Deterioration;Development;Dimensions;Disease susceptibility;Disparity;Dissemination and Implementation;Emergency department visit;Employee;Employment;Enrollment;experience;Face;falls;Feeling suicidal;follow-up;Gender;gender difference;Health;Healthcare;high risk;improved;Individual;Individual Differences;innovation;Inpatients;Institution;Left;Life;Life Cycle Stages;Link;Longitudinal Studies;Longitudinal Surveys;Measurement;Measures;Mediation;men;Mental Health;Methodology;military service;Modeling;Modification;mortality risk;Outcome;Outpatients;Parents;Participant;Pattern;Personal Satisfaction;personalized approach;physical conditioning;Population;Predisposing Factor;Prevention;Prevention approach;Prevention strategy;Probability;Process;psychologic;Recording of previous events;Research;Research Design;resilience;Resources;Risk;Role;Sampling;selective prevention;Services;Severities;Social Work;Spirituality;Statutes and Laws;Stress;Subgroup;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;surveillance data;Surveys;systematic review;theories;Time;Trauma;Veterans;Visit;Woman;Women's prevalence;Work

PROJECT_TITLE: Gender differences in Veteran reintegration and associated suicide risk

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


ORG_CITY: INDIANAPOLIS

ORG_NAME: RLR VA MEDICAL CENTER

ORG_STATE: IN

PHR: In response to widespread opioid-related harms and high-quality evidence supporting nonpharmacological treatments (NPTs) for chronic pain, VHA and other organizations have advanced policies to move away from opioid prescribing toward multimodal approaches to pain that prioritize evidence-based NPTs. However, NPTs are consistently underutilized, and chronic, disabling pain remains a persistent problem, affecting up to 66% of Veterans. Although VHA is addressing system-level barriers to NPT use through expansion of availability of complementary and integrative health therapies, Veteran-level barriers to NPT use and adherence remain. OPTIONS directly addresses Veteran-level barriers with an intervention consisting of individual coaching and a decision aid focused on available, evidence-based NPTs. OPTIONS directly addresses VA priorities of managing chronic pain and sustaining patient engagement in non-medication treatment.

PI_NAMEs: MATTHIAS, MARIANNE S (contact)

PROJECT_TERMS: addiction;Address;Adherence;Affect;Area;arm;Behavior;behavioral health;Belief;Chronic;chronic musculoskeletal pain;chronic pain;chronic pain management;Cognitive Therapy;Communities;Complement;Complementary Health;Control Groups;Decision Aid;Effectiveness;effectiveness testing;effectiveness/implementation trial;Ensure;evidence base;Fostering;Future;future implementation;Goals;group intervention;Guidelines;health related quality of life;hybrid type 1 study;Hybrids;implementation barriers;implementation evaluation;implementation facilitation;implementation facilitators;improved;Individual;innovation;Integrative Medicine;Intervention;intervention effect;Interview;Investments;Life;Life Style;Light;Maintenance;Methodology;Modality;Motivation;motivational enhancement therapy;multimodality;Nonpharmacologic Therapy;novel;Opioid;opioid tapering;Outcome;Pain;Pain interference;Pain management;pain-related disability;patient engagement;patient oriented;Patient-Centered Care;patient-level barriers;Patients;Pharmaceutical Preparations;Policies;prescription opioid;primary care provider;primary endpoint;primary outcome;Provider;psychologic;Qualitative Methods;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Recovery;Reporting;Research;Research Design;response;Risk;Sampling;secondary outcome;Self Efficacy;Site;success;System;system-level barriers;Testing;Time;tool;uptake;Variant;Veterans;Waiting Lists;whole health;Work

PROJECT_TITLE: Options for Pain Management using Nonpharmacological Strategies (OPTIONS)

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Immunization;Infectious Diseases;Vaccine Related

ORG_CITY: LUBBOCK

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: TEXAS TECH UNIVERSITY

PHR: Project Narrative The proposed research is relevant to public health because it will develop a novel technology that can deliver a range of injectable drugs across the skin. The proposed devices will be easy-to-use, low-cost, and scalable, so they are suited for use in developing countries. The project is also perfectly aligned with current NIH goals to increase the range of platform technologies for delivery of nucleic acids.

PI_NAMEs: MARSTON, JEREMY  (contact)

PROGRAM_OFFICER_NAME: FALCONE, JESSICA

PROJECT_TERMS: Address;Back;Biological;Bulla;Cavia;clinically relevant;Communicable Diseases;cost;Dermal;design;Developing Countries;Development;Devices;DNA;DNA Vaccines;Dose;Dyes;Ebola;Environment;fabrication;Family suidae;Gene Expression;Goals;Grant;Head;Hepatitis B;HIV;Human;hypodermic needle;Image;Immune response;Immune System Diseases;improved;in vivo;Injectable;Injections;intradermal injection;Jet Injections;Liquid substance;Marketing;Mass Immunization;Methods;microCT;Middle East Respiratory Syndrome;Modeling;monomer;Needles;Needlestick Injuries;new technology;novel strategies;nucleic acid delivery;Nucleic Acids;pain reduction;Patient Compliance;Patients;Pharmaceutical Preparations;Phobias;plasmid DNA;Polymers;pressure;prototype;Public Health;Research;Self Administration;Skin;Skin Tissue;Statistical Factor Analysis;Suspensions;Techniques;Technology;technology platform;Testing;Tissues;Training;United States National Institutes of Health;Vaccination;Viscosity;wasting;ZIKA

PROJECT_TITLE: Development of Blister packs for intradermal delivery of high-viscosity suspensions

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Prevention;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: GAINESVILLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Untreated anxiety and depression are exceedingly common in people living with HIV (PLWH) in the rural South, a population critically affected by the HIV epidemic. However, outside of routine clinical care, few interventions target anxiety and depression in this population. This project aims to address the mental health treatment gap that exists in PLWH in the rural South, by incorporating an evidence-based mental health intervention into an existing mHealth application with the goal of improving HIV care engagement, antiretroviral therapy adherence and maximizing virologic suppression.

PI_NAMEs: MANAVALAN, PREETI  (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: Address;Adopted;Adoption;Affect;Africa South of the Sahara;antiretroviral therapy;Anxiety;anxiety reduction;anxiety symptoms;Award;Behavior Therapy;Behavioral;Caring;clinical care;Communicable Diseases;Communities;Community Health Aides;Complex;Consolidated Framework for Implementation Research;Consultations;Counseling;Data;depressive symptoms;design;effective intervention;Effectiveness;effectiveness evaluation;effectiveness outcome;effectiveness/implementation study;effectiveness/implementation trial;Epidemic;Evaluation;evidence base;Evidence based intervention;experience;Failure;Florida;Friendships;Goals;Health;Health Personnel;Health Services Accessibility;Health system;Health Technology;HIV;HIV disparities;Hybrids;implementation evaluation;implementation intervention;implementation outcomes;implementation science;improved;Individual;Intervention;intervention delivery;Investments;Maintenance;Medical;Medicine;member;Mental Depression;Mental Health;Mental Health Services;Mentored Patient-Oriented Research Career Development Award;Mentorship;mHealth;mhealth interventions;Modality;Modeling;novel;Outcome;Persons;Physicians;pilot test;Population;problem solving therapy;professor;Program Development;programs;Provider;Qualitative Research;Randomized;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Proposals;Rural;rural area;rural counties;Rural Population;Science;Scientist;skills;social;Societal Factors;Specialist;stakeholder perspectives;System;Target Populations;Technology;technology intervention;therapy adherence;Training;Transportation;Treatment outcome;trial design;underserved community;Underserved Population;Universities;Viral

PROJECT_TITLE: Adaptation and implementation of a behavioral mHealth intervention to reduce anxiety and depression and end the HIV epidemic in the rural South

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: Los Angeles

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative In this proposed project we will investigate different cell types of the inferior colliculus (IC) that are specified by molecular markers identified from single-nucleus RNA sequencing as well as their spatial distribution patterns to interrogate their functional contributions to the central auditory processing and the underlying circuit mechanisms. The study will establish comprehensive understandings of the cellular and organizational bases for different functional roles of the IC in auditory processing and perception, and may provide new mechanistic insights for IC associated hearing impairments.

PI_NAMEs: ZHANG, LI I (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Address;Anatomy;Animals;Auditory;Auditory area;Auditory Perception;auditory processing;Auditory system;awake;base;Behavior;Bioinformatics;biomarker identification;Brain;Brain Stem;candidate marker;Cataloging;Cell Nucleus;cell type;Communication;Coupled;Development;Dorsal;Electrophysiology (science);Endowment;excitatory neuron;Exhibits;Feedback;Genetic Markers;Genomics;Hearing;hearing impairment;Ice;Impairment;in vivo;Inferior Colliculus;inhibitory neuron;insight;Label;Mediating;Methods;Molecular;molecular marker;Mus;Neural Pathways;Neurons;Nitric Oxide Synthase;Nitric Oxide Synthase Type I;optogenetics;Output;Pattern;Physiological;Population;Procedures;Property;Research;response;Role;screening;single nucleus RNA-sequencing;Slice;Somatostatin;sound;Source;Spatial Distribution;Specific qualifier value;Synapses;Testing;transcriptome sequencing;Transgenic Organisms;Viral;Whole-Cell Recordings;Work

PROJECT_TITLE: Cell-type basis for auditory processing in the inferior colliculus


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Gene Therapy;Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: NARRATIVE This work aims to further the development of gene editing for curing human disease.

PI_NAMEs: MCMANUS, MICHAEL T (contact)

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Acceleration;Adenine;Animal Model;Animals;base editing;base editor;Cell model;Cells;Clinic;Clinical;clinical application;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;cost;CRISPR/Cas technology;Cytosine;Data;Data Reporting;design;Development;DNA cassette;ds-DNA;efficacious treatment;Engineering;Ensure;ES Cell Line;experimental study;flexibility;Fluorescence;gene editing technology;gene therapy;Genes;Goals;Histology;human disease;in vivo;Laboratories;LacZ Genes;Liver;Luciferases;Measurement;Modality;monomer;mouse development;Mouse Embryonic Stem Cells;mouse genetics;mouse model;Mus;Nature;novel;Organ;Outcome;Patients;Positioning Attribute;Postdoctoral Fellow;prime editing;prime editor;Proteins;Race;Reagent;redshift;Reporter;Reporter Genes;Reproducibility;Research;Research Personnel;research study;Safety;sensor;Solid Neoplasm;Stains;standard care;System;Technology;Testing;Therapeutic;Time;Tissues;Transgenes;Transgenic Organisms;Validation;Visual;Work;Writing

PROJECT_TITLE: Illuminating gene therapy

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Biotechnology;Chronic Pain;Genetics;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE While chronic pain remains an urgent healthcare issue, our understanding of the brain mechanisms underlying this disease state lack the resolution that has been uncovered for spinal nociceptive circuits. In this application we will use viral-genetic technologies to locate neuronal ensembles that contribute to the process of affective pain chronification. We will then attempt to prevent chronification through targeted modulation of identified ensembles, demonstrating a causative role in the development of chronic pain. The successful completion of these studies will yield new brain targets for the translational development of effective chronic pain treatments that allow patients to still sense pain but without the unpleasant aversion.

PI_NAMEs: BEIER, KEVIN T (contact);CORDER, GREGORY

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Acceleration;Acute;Acute Pain;adaptive learning;Affective;Amygdaloid structure;Anatomy;Animals;Anterior;Area;Automobile Driving;Behavior;Brain;brain circuitry;Brain imaging;brain tissue;cell type;Cells;Chromosome Mapping;Chronic intense pain;chronic neuropathic pain;chronic pain;chronic pain management;chronic pain patient;chronic painful condition;Classification;Color;combat;Complex;Data;Development;Dimensions;Disease;Drug Delivery Systems;Emotional;Emotions;Etiology;Evolution;experience;Female;Functional Magnetic Resonance Imaging;Future;Genetic;genetic approach;genetic manipulation;Genetic Recombination;genetic technology;Glutamates;Goals;healing;Healthcare;Human;human imaging;Image;imaging modality;imaging study;Immediate-Early Genes;In Situ Hybridization;innovation;Insula of Reil;interest;Intervention;invention;Investigation;Light;Link;Literature;male;Maps;Mediating;Mental Health;Methods;Microscopy;Microspheres;Molecular Profiling;motivated behavior;Motivation;multimodal data;Mus;negative affect;Negative Valence;nerve injury;Nervous System;Nervous System Disorder;neural;neural circuit;Neurons;Nociception;Nociceptors;novel;Opioid;opioid mortality;Pain;pain behavior;pain chronification;Pain management;Pain Map;pain patient;pain perception;Pain quality;pain reduction;pain relief;pain sensation;Pathway interactions;Patients;Peripheral;Peripheral nerve injury;Pharmacological Treatment;Pharmacology;Play;Population;Positive Valence;Precision therapeutics;preservation;Presynaptic Terminals;prevent;Process;Rabies;rabies label;rabies viral tracing;receptor;Reporting;Resolution;Rewards;Role;Sensory;side effect;Signal Transduction;single cell sequencing;single nucleus RNA-sequencing;Site;spatiotemporal;Spinal;Structure;System;targeted treatment;Testing;Time;transcriptomics;Virus;virus genetics;Work

PROJECT_TITLE: Investigation of neural ensembles driving pain chronification

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics

ORG_CITY: VALHALLA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: NEW YORK MEDICAL COLLEGE

ORG_STATE: NY

PHR: Vascular diseases continue to be a major cause of death in the US and worldwide. The focus of this proposal is to determine the contributions of altered metabolism and increased glucose-6-phosphate dehydrogenase (G6PD) activity and expression to the development of deadly vascular diseases. We anticipate the results of this project will reveal the direct linkage between G6PD and expression of genes that contribute to vascular pathology and will further the development of new treatments to reduce vascular diseases.

PI_NAMEs: GUPTE, SACHIN A (contact);MIANO, JOSEPH M

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Affect;African;arterial stiffness;Arteries;ATAC-seq;Biology;Blood Vessels;Cardiovascular system;Carotid Arteries;Cause of Death;Cell Nucleus;Cessation of life;Chromatin;Coronary Arteriosclerosis;Coronary artery;design;Development;Disease;DNA;DNA Binding;DNA Methylation;DNA Modification Methylases;DNase-I Footprinting;Enzymes;Epigenetic Process;epigenome;epigenomics;Evolution;Experimental Designs;FAIRE sequencing;Frequencies;gain of function;Gene Expression;Gene Expression Profile;Genes;Genetic Polymorphism;Genetic Transcription;glucose metabolism;Glucosephosphate Dehydrogenase;Goals;Growth;Heart failure;High Fat Diet;histone methylation;Histones;Human;Hypertension;Individual;Inflammatory;Injury;Knowledge;Laboratories;Life;Link;loss of function;Lysine;Mechanics;Medicine;Metabolic;Metabolic syndrome;Metabolism;metabolomics;Methylation;migration;Modeling;Modernization;Modification;Molecular Weight;myocardin;NADP;new therapeutic target;novel;Nuclear;Obesity;Oxidation-Reduction;Pathogenesis;Pathogenicity;Pathology;Phenotype;Predisposition;prevent;prime editing;promoter;Property;Protein Isoforms;Proteins;Pulmonary artery structure;Rattus;Regulation;Repression;Role;Signal Transduction;Single Nucleotide Polymorphism;Smooth Muscle Myocytes;Switch Genes;Technology;Testing;thrombotic;transcription factor;Variant;Vascular Diseases;Vascular remodeling;Vascular Smooth Muscle

PROJECT_TITLE: Regulation of Vascular Smooth Muscle Cell Phenotype by a Novel Isoform of Glucose-6-Phosphate Dehydrogenase

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: LA JOLLA

ORG_DEPT: ZOOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Many human diseases and malformations are caused by disruption of the early stages of life. Animal model organisms are essential for studying how these early stages work, and for understanding how diverse environmental agents – from toxic chemicals to pathogens – affect health. Here we will develop transformative new tools to enable rapid genetic manipulation of a classical developmental animal model, used widely to understand these relationships between development and disease. The resulting resource will dramatically accelerate the tempo and impact of more than 20 current NIH sponsored projects using this research organism.

PI_NAMEs: HAMDOUN, AMRO M (contact)

PROGRAM_OFFICER_NAME: ZOU, SIGE

PROJECT_TERMS: Acceleration;Adult;Affect;Animal Genetics;Animal Model;animal resource;Binding;Biogenesis;Biological;Biomedical Research;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Communities;Cre-LoxP;CRISPR/Cas technology;Cyclins;design;Development;Disease;DNA;DNA Transposable Elements;early life exposure;Embryo;experimental study;Fertility;Fertilization;fluorescence imaging;Foundations;Gene Expression Regulation;gene regulatory network;Gene Transfer Techniques;Generations;Genes;Genetic;genetic approach;genetic manipulation;Genetic Recombination;Genome;Genome engineering;Germ Lines;Goals;Health;Human;human disease;improved;Injections;innovation;Integrase;Investments;Knock-out;Knowledge;Laboratories;Life;Lytechinus;malformation;Mediating;Membrane;Messenger RNA;Methodology;Methods;Mitotic;model organism;Modeling;Modernization;Modification;Mutagenesis;mutant;National Institute of Child Health and Human Development;National Institute of Environmental Health Sciences;National Institute of General Medical Sciences;Nobel Prize;Nonhomologous DNA End Joining;Optics;Organism;Outcome;pathogen;Phenotype;Phylogenetic Analysis;Poison;Production;programs;promoter;recombinase-mediated cassette exchange;repaired;Reporter;Reproducibility;Reproduction;Research;Research Infrastructure;Research Personnel;Resource Sharing;Resources;Sea Urchins;Seminal;Site;Specificity;Structure;Study models;success;Techniques;Technology;Time;Tissues;tool;Toxic effect;Toxic Environmental Substances;transgene expression;Transgenic Organisms;Transmembrane Transport;Transposase;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Development of foundational building blocks for stable genetic modification of sea urchin embryos

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE Respiratory virus infection in early life increases asthma risk in susceptible individuals, imposing a major public health burden. The primary goal of this project is to define the molecular mechanisms by which GSDMB, a well-replicated gene associated with asthma in genome-wide association studies (GWAS), promotes virus- induced innate immune response, thereby contributes to asthma development. This novel concept may shed fresh insights into the biological mechanisms for variable virus-induced innate immune response and pinpoint to novel treatment for asthma.

PI_NAMEs: ZHOU, ANNY XIAOBO (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: 17q;17q21;2019-nCoV;Acute;Affect;Age;Air;airway epithelium;airway hyperresponsiveness;airway inflammation;analog;Anti-viral Response;Asthma;asthma exacerbation;asthmatic;asthmatic patient;Binding;Biochemical;Biological;bronchial epithelium;Cell model;Cells;chemokine;Child;Childhood Asthma;Chromosomes;Data;Development;DNA;Double-Stranded RNA;Drug Targeting;Environmental Risk Factor;Epithelial Cells;Family member;gene environment interaction;Genes;Genetic;Genetic Transcription;genome wide association study;genome-wide analysis;Genotype;Goals;Guide RNA;Health;Homologous Gene;Human;Hyperplasia;Immune response;In Vitro;in vivo;Individual;inducible gene expression;infancy;Infant;Infection;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Innate Immune Response;insight;Interferon Activation;Interferons;Invaded;Knock-out;late life;Life;Liquid substance;Measures;Mediating;Modeling;Molecular;mouse model;Mucous body substance;mucus hypersecretion;Mus;Neonatal;neonatal mice;novel;Nucleic Acids;overexpression;pandemic disease;Persons;Poly I-C;Precision therapeutics;Predisposition;prevent;Production;promoter;Public Health;respiratory;Respiratory Disease;respiratory infection virus;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;respiratory virus;response;Rhinovirus infection;Risk;risk variant;RNA;RNA Virus Infections;RNA Viruses;Role;School-Age Population;sensor;Series;Severities;Signal Pathway;Signal Transduction;social;Susceptibility Gene;Testing;Time;Transgenic Mice;unpublished works;Viral;Viral Proteins;viral RNA;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Molecular understanding of the GSDMB-regulated innate immune response

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Viruses in the Reoviridae family infect a wide range of hosts, including animals, plants, fungi, and bacteria; within this family, rotaviruses cause 450,000 deaths worldwide each year, and BTV kills livestock, with devastating economic and social consequences. The proposed structural and functional studies focus on BTV and CPV to provide structural answers to fundamental questions of replication of these and other dsRNA viruses. The results will provide profound insight into the structural basis of dsRNA virus spread and inform rational development of anti-viral drugs and vaccines against these and other viruses.

PI_NAMEs: ZHOU, Z HONG (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: 2019-nCoV;Animals;Anti-viral Response;antiviral drug development;Aquareoviruses;Bacteria;Basic Science;Biochemical;Biological Models;Bluetongue virus;Capsid;Capsid Proteins;Cells;Cessation of life;Child;Chimeric Proteins;Classification;Communities;comparative;Complex;Cryoelectron Microscopy;Cues;Cytoplasm;Cytoplasmic Polyhedrosis Viruses;Detection;Double Stranded RNA Virus;Double-Stranded RNA;Drug Delivery Systems;Economics;electron tomography;Electrons;endosome membrane;Engineering;Environment;Enzymes;Event;Family;Flu virus;Funding;fungus;Gastroenteritis;General Population;Genetic Transcription;Genome;genomic RNA;Goals;Grant;Health Sciences;HIV;Human;In Situ;Infectious bursal disease virus;Insect Viruses;Insecta;insight;interest;Invaded;Ions;Iris;Lead;Life Cycle Stages;Link;Literature;Livestock;member;Membrane Proteins;Messenger RNA;Modeling;Molecular Biology;Molecular Conformation;mRNA capping;Multienzyme Complexes;Mutagenesis;N-terminal;nanometer resolution;novel;nucleoside triphosphatase;particle;pathogen;Pattern;Phase;Plants;Polymerase;Proteins;Public Health;Publishing;reconstruction;Recording of previous events;Reoviridae;Reovirus;replicator;Rhesus;RNA;RNA Caps;RNA replication;RNA-Directed RNA Polymerase;Role;Rotavirus;social;Structure;Surface;System;Techniques;Technology;Testing;Transcriptional Activation;Trichomonas vaginalis;vaccine development;Vaccines;Variant;Viral;Viral Genome;Virion;Virus;Virus Assembly;virus core;Visualization;Work

PROJECT_TITLE: Genome structure, transcription and packaging of dsRNA viruses

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Mental Health;Pediatric;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: Young adults experiencing homelessness have high rates of mental health conditions but low rates of service utilization and the point of transition from homelessness to supported housing provides a window of opportunity for intervention. Therefore, there is a critical need to develop interventions to support young adult mental health at the point of transition from homelessness to housing. The goal of this study is to adapt the evidenced-based intervention, Critical Time Intervention, for young adults with mental health conditions and test the adapted intervention in a randomized feasibility pilot trial.

PI_NAMEs: NARENDORF, SARAH CARTER (contact)

PROGRAM_OFFICER_NAME: MAVANDADI, SHAHRZAD

PROJECT_TERMS: Address;Administrator;Adult;Age;Anxiety;care coordination;Caring;Case Management;Case Manager;Characteristics;Clinic;Communities;Community Healthcare;Continuity of Patient Care;Coupled;COVID-19 pandemic;Development;Diagnosis;Effectiveness;Elements;Ensure;Evidence based intervention;Evidence based practice;experience;Face;family support;federal policy;Feedback;Focus Groups;Foundations;Funding;Future;Goals;Health;health service use;High Prevalence;Homelessness;Housing;housing instability;improved;Individual;innovation;Institute of Medicine (U.S.);Intervention;Intervention Studies;Investigational Therapies;Manuals;marginalized population;member;Mental disorders;Mental Health;Mental Health Services;Mentors;Modeling;Moods;National Institute of Mental Health;Outcome Measure;Outcomes Research;Outpatients;peer support;person centered;Phase;pilot test;pilot trial;Population;Population Heterogeneity;preference;primary outcome;Procedures;Process;programs;Protocols documentation;Provider;Randomized;Randomized, Controlled Trials;Recommendation;Recovery;Recurrence;reduce symptoms;Research Priority;Self Efficacy;service utilization;Services;severe mental illness;Signal Transduction;skill acquisition;social stigma;Social support;Structure;substance use;success;supported housing;Symptoms;Testing;therapy design;therapy development;Time;Training;Trauma;United States;Variant;Work;working group;young adult;Youth

PROJECT_TITLE: Adaptation of Critical Time Intervention for Young Adults with Mental Health Challenges in the Transition from Homelessness to Housing


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Digestive Diseases;Immunization;Orphan Drug;Rare Diseases;Stomach Cancer;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE – The vast majority of patients with HER2-positive breast and gastric cancers become refractory to anti-HER2 antibody-drug therapies, and HER2-negative or several other non-breast/non-gastric tumors do not respond to classical anti-HER2 therapy. We found that methodologies increasing the internalization rates of the HER2 receptor can be exploited by antibody-drug conjugates to effectively treat heterogeneous HER2 diseases. This proposal seeks to optimize a methodology of antibody-drug internalization to overcome drug resistance in HER2-positive and HER2-negative tumors.

PI_NAMEs: RIBEIRO PEREIRA, PATRICIA MANUELA  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Affinity;Antibodies;Antibody Binding Sites;Antibody Therapy;Antibody-drug conjugates;Binding;Biodistribution;Breast;Breast Cancer Cell;Breast Cancer Model;cancer cell;Cancer cell line;Cancer Etiology;Cell surface;Classification;Clinical;clinical translation;Clinical Trials;Complex;Copper;crosslink;Cyclooctenes;cytotoxic;Data;Dimerization;Disease;Disease Progression;Dose;dosimetry;Drug Delivery Systems;Drug Kinetics;Drug resistance;drug sensitivity;effective therapy;Effectiveness;Eligibility Determination;Endocytosis;Epitopes;ERBB2 gene;extracellular;Foundations;Future;gastric cancer cell;Goals;Heterogeneity;Human;Image;imaging study;Imaging technology;Immunohistochemistry;improved;improved outcome;Incidence;Investigation;Label;Malignant Breast Neoplasm;Malignant Neoplasms;malignant stomach neoplasm;Mammary Neoplasms;Medical;Membrane;Methodology;Molecular;molecular imaging;Monitor;mortality;Mutation;novel;novel strategies;novel therapeutic intervention;Oncogenic;Organoids;Pathway interactions;Patient Care;patient derived xenograft model;Patients;permissiveness;Pertuzumab;Pharmaceutical Preparations;Pharmacotherapy;Population;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;preclinical study;Predisposition;prevent;Protein Overexpression;Proteins;Randomized;Reaction;receptor;Receptor Protein-Tyrosine Kinases;Refractory;Resistance;Resistance development;resistance mechanism;response;Safety;Scheme;Signal Pathway;Site;standard of care;Stomach;Stomach Neoplasms;Surface;targeted delivery;Testing;Therapeutic;Therapeutic Studies;therapeutically effective;therapy resistant;Time;Tissues;Toxic effect;trafficking;Translations;Trastuzumab;Treatment Efficacy;Treatment outcome;treatment response;tumor;tumor heterogeneity;uptake;Xenograft procedure

PROJECT_TITLE: Reversing Drug Resistance in Tumors with Clickable Antibody Pairs

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Pediatric;Primary Health Care

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative The primary goal of this research is to conduct a randomized, controlled feasibility trial to investigate whether ADHD question prompt lists, a pre-visit video, or ADHD question prompt lists and a pre-visit video improve communication during pediatric visits which in turn improves adolescent ADHD symptoms, school and social performance, and quality-of-life compared to those in the usual care group. The findings will be used to plan a larger trial. If successful, this intervention could be easily disseminated to pediatric practices across the country, improving the health of adolescents with ADHD.

PI_NAMEs: SLEATH, BETSY LYNN (contact)

PROGRAM_OFFICER_NAME: MARRO, MARY ACRI

PROJECT_TERMS: Adolescent;adolescent health;Age;Asthma;Attention deficit hyperactivity disorder;Caring;Childhood;Clinic;Communication;Country;Diagnosis;Education;Effectiveness;Effectiveness of Interventions;Enrollment;Family;feasibility trial;Feedback;Focus Groups;Goals;group intervention;Hyperactivity;improved;improved outcome;Impulsivity;inattention;Institute of Medicine (U.S.);Intervention;Intervention Trial;Learning;Link;Medical;Medical Records;Medicine;Mental Health;novel;Office Visits;Outcome;Parents;Participant;Performance;Pharmaceutical Preparations;pilot trial;Primary Care;primary care setting;primary care visit;Provider;provider communication;Quality of life;Randomized;Reporting;Research;Safety;Schools;Self Efficacy;shared decision making;social;social cognitive theory;Symptoms;Testing;treatment arm;treatment as usual;video visit;Visit;Work;Youth

PROJECT_TITLE: Improving the outcomes of adolescents with ADHD via a pre-visit question prompt list/video intervention: a randomized controlled feasibility trial


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Narrative These studies are relevant to obstructive vascular disease, an important process that is the root cause of myocardial infarctions (‘heart attacks’) and strokes. Obstructive vascular disease results from changes in cells in blood vessel walls as they respond to various stresses and disease conditions, including high blood pressure, high cholesterol, diabetes, smoking, and genetic factors. We focus here on a protein called FAT1 that controls the production within cells of energy and biochemical ‘building blocks’ necessary for cell growth and other activities, and also affects gene expression. We believe that these different effects of FAT1 arise from fragments of the protein that are located in distinct compartments within cells. The studies we propose here are designed to understand how these FAT1 fragments control important cellular activities, and how these activities in turn affect the development of vascular obstruction. Such understanding may lead to new ways to intervene to decrease vascular obstruction.

PI_NAMEs: SIBINGA, NICHOLAS E (contact)

PROJECT_TERMS: Acceleration;Affect;Affinity;Animal Model;Apolipoprotein E;Arterial Fatty Streak;Arterial Injury;Arteries;Arteriosclerosis;Atherosclerosis;Biochemical;Biology;Blood Vessels;Cadherins;cancer cell;Cell Differentiation process;cell growth;Cell membrane;Cell Nucleus;Cell Polarity;Cell Proliferation;Cell surface;cell type;Cells;Cellular Metabolic Process;Cholesterol;comparison control;Complex;Cytoplasm;Cytoplasmic Protein;design;Development;Diabetes Mellitus;Disease;disease model;DNA;Drosophila genus;extracellular;Failure;Family;FAT gene;Fatty acid glycerol esters;Feedback;gain of function;Gene Expression;Gene Expression Regulation;Genetic;Genetic Markers;Goals;GPC3 gene;Growth;Human;Hypertension;In Vitro;in vivo;injured;Injury;Integral Membrane Protein;Length;Lesion;Link;Location;loss of function;Mammals;Membrane Proteins;Metabolic;Metabolism;migration;Mitochondria;Mitochondrial Proteins;Modeling;mouse model;Mus;Myocardial Infarction;Myocardial Ischemia;NADH dehydrogenase (ubiquinone);new therapeutic target;Nuclear;Obstruction;Oxidative Phosphorylation;Pathogenesis;Pathway interactions;Peptide Hydrolases;Peripheral arterial disease;Phenotype;Positioning Attribute;Process;Production;programs;Proliferating;Protein Fragment;protein function;Protein Isoforms;Proteins;Regulation;Reporting;response;restenosis;revascularization;RNA;RNA Splicing;Role;Saphenous Vein;Signal Transduction;Smoking;Smooth Muscle Myocytes;Stents;Stress;Stroke;success;Testing;transcription factor;Transplantation;Up-Regulation;Vascular Diseases;vascular injury;Vascular remodeling;Vascular Smooth Muscle;Vein graft

PROJECT_TITLE: FAT cadherins and vascular remodeling

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative Majority of deaths in breast cancer patients are attributed to the metastatic spread of the disease to distant sites potentiated by an immunosuppressive tumor-microenvironment and their resistance to various therapeutic strategies, including immune checkpoint blockade (ICB). This study aims to understand the mechanism(s) by which mesenchymal carcinoma cells resist elimination by ICB with the goal of identifying and interrupting signalling channels specifically associated with mesenchymal carcinomas to potentiate the effects of ICB. Thus, the proposed work highlights the prospect of using the polarization of carcinoma cells towards the epithelial-mesenchymal spectrum as a surrogate marker for predicting responses to ICB.

PI_NAMEs: DONGRE, ANUSHKA  (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: anti-CTLA4;Biological Process;Breast Cancer Patient;Breast Carcinoma;Carcinoma;Cell Line;Cells;Cessation of life;Characteristics;chemokine;cytokine;Cytoprotection;cytotoxic CD8 T cells;Data;diagnostic biomarker;Disease;Distant;Endocrine;Epithelial Cells;epithelial to mesenchymal transition;Epithelium;Exclusion;exhaust;exhaustion;Exhibits;Goals;Immune;immune cell infiltrate;immune checkpoint blockade;immune clearance;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;in vivo Model;Infiltration;Interruption;Intervention;Intrinsic factor;Macrophage;Maintenance;Malignant Breast Neoplasm;Malignant Epithelial Cell;Mediating;Mesenchymal;Mesenchymal Cell Neoplasm;Minority;Modeling;Molecular;Motility;neoplastic cell;novel;novel diagnostics;Outcome;paracrine;Patients;Pharmaceutical Preparations;predicting response;Prognostic Marker;Property;recruit;Refractory;Regulatory T-Lymphocyte;Resistance;response;Sampling;Signal Transduction;Site;Surrogate Markers;Therapeutic;tumor;tumor initiation;tumor microenvironment;tumor-immune system interactions;Work

PROJECT_TITLE: Potentiating the Efficacy of Immune Checkpoint Blockade by Targeting Epithelial-Mesenchymal Transition (EMT)-induced Immunosuppression in Breast Carcinomas


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Foodborne Illness;Neurosciences;Pediatric

ORG_CITY: VENTURA

ORG_NAME: COASTAL MARINE BIOLABS

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE This research education project will create novel opportunities for high school teachers and students to explore the interplay of naturally occurring marine neurotoxins, environmental health science, and public health safety. Although the research experience is interdisciplinary in scope, conceptual emphasis will be placed upon the clinical syndromes associated with consumption of shellfish containing marine neurotoxins (e.g., amnesic and paralytic shellfish poisoning) and effects of phytoplankton-derived marine biotoxins on neurotransmission. The experience will also enable students to explore the efforts of public health agencies to mitigate the health risks of marine neurotoxins.

PI_NAMEs: IMONDI, RALPH  (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: Affect;Algae;Aquaculture;Area;Award;Biological Monitoring;Biological Sciences;Bivalvia;California;Clinical;Collaborations;Communication;Communities;Complement;computational reasoning;Consultations;Consumption;Data Analyses;Data Set;design;Development;Economics;Education Projects;education research;Educational Curriculum;Educational process of instructing;eleventh grade;Environmental Health;Evaluation;experience;Fisheries;food security;Fostering;Future;Goals;Grant;Harvest;Health;high school;High School Faculty;High School Student;Human;Industry;industry involvement;innovation;Instruction;interest;Internships;Investigation;K-12 science education;Knowledge;Laboratories;Learning;learning community;Link;Location;marine;Marine Toxins;Marketing;Mathematics;meetings;Methodology;Modeling;Monitor;National Oceanic and Atmospheric Administration;National Research Council;neurotoxic;Neurotoxins;neurotransmission;Next Generation Science Standards;novel;Oceanography;Paralysed;Patients;pedagogy;Phase;Phytoplankton;Poisoning;Privatization;Process;Production;programs;Protocols documentation;Public Health;public health relevance;Recommendation;Recreation;Research;Resources;Risk;Role;Safety;Science;science education;science teacher;Scientist;Seafood;Shellfish;skills;Structure;student participation;Students;Syndrome;teacher;Teacher Professional Development;Teaching Method;Toxic Environmental Substances;Translating;twelfth grade;United States Food and Drug Administration;Universities;vision science;Water

PROJECT_TITLE: Marine Neurotoxins:  Examining the impacts of a pedagogically focused RET model that explores the interplay of marine biotoxins, commercial shellfish aquaculture, and public health safety


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: EAST LANSING

ORG_DEPT: PEDIATRICS

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Cancer cells use autophagy, a cellular recycling process that plays an essential role in treatment resistance and allows cancer cells to survive nutrient and oncogenic stress. As such, targeting autophagy has become a critical therapeutic strategy in cancer, and our laboratory has discovered the most selective and potent autophagy inhibitor to date: ULK-101. This proposal will evaluate the efficacy of ULK-101 in mouse models of pancreatic cancer with dual immune checkpoint blockade, which will provide critical data to support autophagy inhibitors as a viable pancreatic cancer treatment option.

PI_NAMEs: MACKEIGAN, JEFFREY PAUL (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Address;American;Anti-malarials;anti-PD-1;Autophagocytosis;Benchmarking;cancer cell;Cancer cell line;cancer therapy;Cell Line;Cell surface;Cell Survival;Cells;Cessation of life;chemoproteomics;Chemotherapy and/or radiation;Clinic;Combination immunotherapy;Curative Surgery;Cyclic AMP-Dependent Protein Kinases;Data;Dependence;Development;Diagnosis;Disease;Disease Progression;DNA Binding;drug testing;efficacy evaluation;Environment;Excision;Extracellular Matrix Proteins;Face;Fibroblasts;Genetic;Genetic Complementation Test;Genetic Engineering;Genetically Engineered Mouse;Half-Life;Human;Hydroxychloroquine;Immune;immune checkpoint blockade;Immune Evasion;Immune system;Immunotherapy;Impairment;improved;in vivo;inhibition of autophagy;inhibitor;innovation;Investigation;KRAS oncogenesis;KRAS2 gene;KRASG12D;Laboratories;Major Histocompatibility Complex;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;MEKs;Metabolic;Modeling;mouse model;Mus;mutant;Mutation;neoplastic cell;NOD/SCID mouse;novel;Nutrient;Oncogenic;Organ;Pancreas;pancreatic cancer cells;pancreatic cancer model;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;pancreatic stellate cell;Patients;pharmacologic;Phosphotransferases;Play;pre-clinical;Pre-Clinical Model;preclinical development;Predisposition;Process;Qualifying;Radiation therapy;Recycling;Refractory;Reporting;Role;side effect;Site;small molecule inhibitor;Specificity;Starvation;Stress;Stromal Cells;Survival Rate;synergism;targeted agent;Technology;Testing;Therapeutic;therapy resistant;Tissues;TP53 gene;Translations;Treatment Efficacy;tumor;Tumor Burden;tumor growth;tumor hypoxia;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Suppressor Proteins;Tumor Tissue;United States;Xenograft procedure

PROJECT_TITLE: ULK1 Inhibitor in Combination with Immune Checkpoint Blockade in PancreaticCancer


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Dietary Supplements

ORG_DEPT: CHEMISTRY

PHR: Proteoglycans important roles in many biological processes such as inflammation, cell proliferation and cancer development. In this project, new methods will be developed to greatly expedite the synthesis of proteoglycan like molecules bearing homogeneous carbohydrate chains. The availability of these complex molecules can significantly aid in the better understanding of their fascinating biological functions, and provide potential targets for the development of novel therapeutics.

PI_NAMEs: HUANG, XUEFEI  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Abbreviations;Acids;Alkynes;Alzheimer's Disease;Anti-Inflammatory Agents;Aspartic Acid;Azides;bikunin;Biological;Biological Process;Carbohydrates;CCL13 gene;Cell Proliferation;Cell surface;chemical synthesis;Chemicals;Chondroitin Sulfate A;Chondroitin Sulfate C;chondroitin sulfate glycosaminoglycan;Chondroitin Sulfate Proteoglycan;Chondroitin Sulfates;Complex;Copper;Core Protein;cycloaddition;Cysteine;Deacetylase;Development;Dipeptides;Disaccharides;Enzymes;epimerase;Event;Exhibits;Extracellular Matrix;fascinate;FGF2 gene;Fluorescein;Fluorescein-5-isothiocyanate;Galactose;Glucosamine;Glucuronic Acids;Glucuronosyltransferase;Glycine;Glycopeptides;Glycoproteins;Glycosaminoglycans;Grant;Heparan Sulfate Proteoglycan;Heparitin Sulfate;Heterogeneity;Histidine;Inflammation;Inflammatory;Interferometry;Interleukins;Investigation;Isothiocyanates;Life;Ligands;Ligation;Link;Lipopolysaccharides;Malignant Neoplasms;Mammalian Cell;Mass Spectrum Analysis;Mediating;Methodology;Methods;Molecular;Molecular Probes;Nature;novel;novel therapeutics;Nuclear Magnetic Resonance;Output;Peptides;Pharmaceutical Preparations;Pharmacotherapy;Play;Polyethylene Glycols;polypeptide;Polysaccharides;Property;Proteoglycan;Role;Sepsis;Serine;sortase;Structure;Sulfate;sulfotransferase;syndecan-4;Synthesis Chemistry;tau aggregation;Threonine;Time;TLR4 gene;TNF gene;tool;Transferase;Trifluoroacetic Acid;Uridine Diphosphate;Vertebral column;Xylose

PROJECT_TITLE: Enabling synthesis and biological studies of homogeneous heparan sulfate and chondroitin sulfate glyco-polypeptides and proteoglycans

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: PROJECT NARRATIVE The proposed work aims to develop and optimize a new class of super-resolution imaging, referred to as spectroscopic single-molecular localization microscope or sSMLM. It will allow biomedical researchers, for the first time, to achieve multi-color imaging with molecular specificity at sub 5-nm spatial precision and 0.5-nm spectral resolution. sSMLM will open up new frontiers in biological research, in which it is possible to image sophisticated intracellular multi-molecular interactions with nanometer resolution in three dimensions.

PI_NAMEs: SUN, CHENG  (contact);ZHANG, HAO F

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 3-Dimensional;Address;Algorithms;Astigmatism;Astronomy;Binding;Biological;Biological Models;Biological Process;biological research;Biomedical Research;Blinking;Budgets;Calibration;Cell Physiology;Cells;Cellular Structures;Color;Communities;Complex;Computer software;computerized data processing;Data;design;Development;Engineering;Ensure;Environment;Experimental Designs;Foundations;frontier;Goals;Hybrids;Image;image processing;Imaging Device;imaging platform;Imaging technology;Individual;innovation;Location;Measures;meetings;Methodology;Microscope;microscopic imaging;Microscopy;Modeling;Modernization;Modification;Molecular;molecular imaging;nano;nanoengineering;nanometer resolution;nanoscale;Noise;novel;Nuclear Pore Complex;open data;open source;operation;optical emission;optical imaging;optical nanoscopy;optical spectra;Optics;Performance;Photons;Physiological;Play;Plug-in;programs;Protocols documentation;Research;Research Personnel;Resolution;Role;Sampling;Science;single molecule;software development;Specificity;Spectrum Analysis;superresolution imaging;System;Techniques;Technology;technology research and development;Theoretical model;Three-Dimensional Imaging;Time;tool;ultra high resolution;Validation;Visualization;Work

PROJECT_TITLE: Development of spectroscopic Single-Molecule Localization Microscopy

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Antibacterial resistance (AR) is one of the world’s top health threats. It is a complex, growing problem. Reducing the burden of AR requires a sustained program that simultaneously addresses critical issues from many perspectives. Our goal is to continue to advance our success of the Antibacterial Resistance Leadership Group (ARLG) that has developed, designed, implemented, and managed a clinical research agenda that increases knowledge of AR, and reduces the factors that drive its emergence.

PI_NAMEs: FOWLER, VANCE G. (contact);HENRY CHAMBERS, HENRY F

PROGRAM_OFFICER_NAME: MOON, KYUNG

PROJECT_TERMS: Address;Area;Award;Bacteria;Bacterial Drug Resistance;Bacterial Infections;bacterial resistance;Bacteriophages;biobank;Biometry;Childhood;Clinical;clinical diagnostics;clinical epidemiology;Clinical Research;Clinical Trials;Clinical Trials Network;Collaborations;Communities;Complement;Complex;Data Analyses;Data Coordinating Center;data management;design;Development;Diagnostic;Diagnostic tests;Drug Industry;Drug resistant Pseudomonas aeruginosa;Ensure;Evaluation;experience;fundamental research;Gene Expression;Genitalia;Goals;Gonorrhea;Gram-Negative Bacteria;Gram-Negative Bacterial Infections;Gram-Positive Bacterial Infections;Health;Human;improved outcome;Infrastructure;innovation;Interdisciplinary Study;International;Knowledge;Laboratories;Laboratory Research;Lead;Leadership;member;Mentors;Messenger RNA;methicillin resistant Staphylococcus aureus;Methodology;Molecular Epidemiology;Monoclonal Antibodies;Multi-Drug Resistance;multi-drug resistant pathogen;next generation;novel diagnostics;operation;organizational structure;Paper;Participant;pathogen;Patients;Phenotype;Pneumonia;Positioning Attribute;Principal Investigator;Productivity;Program Sustainability;programs;protocol development;Protocols documentation;Publications;Publishing;Randomized, Controlled Trials;Research;Research Activity;Research Design;Research Infrastructure;Research Institute;Research Personnel;Resources;Respiratory Tract Infections;Robin bird;scaffold;Sepsis;Services;Site;statistics;success;Technology;Testing;Therapeutic;Therapeutic Clinical Trial;Training;Training Support;United States Food and Drug Administration;Viral;virtual group;World Health Organization


ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

PHR: Project Narrative  Drug resistance due to activation or reactivation of alternative RTK signal pathways has been a major clinical challenge for the treatment of lung cancer. Successful completion of this project will offer effective GRB2-targeting degraders as lead compounds for a new targeted therapy to address this difficult problem.

PI_NAMEs: JI, HAITAO MARK (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: acquired drug resistance;Adaptor Signaling Protein;Address;anaplastic lymphoma kinase;Binding;Binding Proteins;Biochemical;Biological;Biological Assay;Biological Availability;Cancer cell line;Cancer Model;Cancer Patient;Carboxylic Acids;Cell Line;Cells;cellular targeting;Clinic;Clinical;Complex;CRISPR interference;Data;design;Down-Regulation;Drug resistance;efficacy evaluation;Epidermal Growth Factor Receptor;experience;Generations;Genes;genome-wide;genome-wide analysis;Goals;Growth Factor;immune checkpoint blockade;Immunotherapy;Impairment;improved;inhibitor;innovation;kinase inhibitor;knock-down;KRAS2 gene;Lead;Length;Ligands;Link;lung cancer cell;Malignant neoplasm of lung;Maps;Mediating;Membrane;molecular targeted therapies;mutant;Mutation;new growth;new therapeutic target;Oncogenic;Pathway interactions;Patients;Permeability;Pharmaceutical Preparations;pharmacologic;Pilot Projects;Protac;protein protein interaction;Proteins;Receptor Activation;Receptor Protein-Tyrosine Kinases;Receptor Signaling;Recurrent disease;Relapse;Resistance;response;Signal Pathway;Signal Transduction;small hairpin RNA;Structure;success;Systems Biology;targeted treatment;Testing;therapy development;tumor;Tyrosine Kinase Inhibitor;ubiquitin-protein ligase;vector

PROJECT_TITLE: Developing GRB2-PROTACs for Treatment of Lung Cancer


ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Micronuclei are aberrant nuclear compartments that can form as a result of chromosome mis-segregation. Frequent loss of micronuclear envelope integrity exposes DNA to the cytoplasm, leading to genomic DNA re- arrangements and immune activation. Building on our prior work, we now propose to determine the mecha- nisms of DNA damage and immune activation at micronuclei.

PI_NAMEs: MACIEJOWSKI, JOHN  (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Anaphase;anti-tumor immune response;Automobile Driving;Biochemical;cancer genome;Cell division;Cell Nucleus;Cells;Cellular biology;Chromatin;Chromosomal Instability;chromosome missegregation;Chromosome Segregation;Chromosomes;chromothripsis;Chronic;Collaborations;Complex;Crows;Cytoplasm;Data;Defect;Digestion;Disease;DNA;DNA Binding;DNA Damage;DNA Sequence Rearrangement;DNA-Binding Proteins;Docking;Electron Transport Complex III;endonuclease;Endoplasmic Reticulum;Environment;Etiology;Evolution;Exhibits;Functional disorder;Gene Rearrangement;Genes;Genome;genome integrity;Genomic DNA;Genomic Instability;Goals;Health;Human;Immune;immune activation;Immune signaling;Immune System Diseases;immunoregulation;improved;Incentives;Individual;Inflammatory;insight;Interphase;Laboratories;Lead;Letters;Malignant Neoplasms;Membrane;Methods;micronucleus;Missense Mutation;Mitosis;Modeling;Molecular;Mutagenesis;Mutate;Mutation;mutation carrier;N-terminal;novel;Nuclear;Nuclear Envelope;Numerical Chromosomal Abnormality;Pathway interactions;Pattern;Penetration;Phase;Play;polyproline;Positioning Attribute;prevent;Process;Prognosis;protein protein interaction;Proteins;Proteomics;pseudotoxoplasmosis syndrome;recruit;repaired;Resected;Role;Rupture;sensor;Site;Source;Stimulator of Interferon Genes;Structural Chromosomal Abnormality;Structure;Testing;Therapeutic;therapy resistant;Three Prime Repair Exonuclease 1;Topoisomerase;TREX1 gene;TREX2 gene;tumor;Tumor Immunity;Vesicle;Viral;Work

PROJECT_TITLE: Immune control and genomic instability at micronuclei

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Orphan Drug;Rare Diseases;Skin Cancer

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE This R21 research project will identify innovative small molecule compounds that target alternative regions of the cancer protein focal adhesion kinase (FAK). This project will help identify a new class therapeutics for multiple solid tumors; including breast, pancreatic, melanoma, ovarian, colorectal, and lung cancers. Furthermore, it will develop advanced drug screening technologies to target protein-protein interactions in cancer cells and improve upon current therapies that target FAK.

PI_NAMEs: MARLOWE, TIMOTHY A (contact);THATCHER, GREGORY R. J

PROJECT_TERMS: 3-Dimensional;Affinity;alpha helix;analog;angiogenesis;anti-cancer;Antineoplastic Agents;Apoptosis;Apoptotic;beta catenin;Binding;Binding Sites;Biochemical;Biological;Biological Assay;Biological Availability;biophysical techniques;Biophysics;Breast;C-terminal;cancer cell;cancer therapy;CD47-SIRPα;Cell Adhesion;cell motility;Cells;Cellular Assay;Chemicals;Clinical;Clinical Trials;Colorectal;Colorectal Cancer;comparative efficacy;Complex;counterscreen;Cytostatics;cytotoxicity;Data;DCC gene;design;Development;Dimethyl Sulfoxide;Dominant-Negative Mutation;Drug Kinetics;Drug Screening;Drug Targeting;Engineering;Epithelium;experimental study;Fluorescence Resonance Energy Transfer;Focal Adhesion Kinase 1;Focal Adhesions;Future;genetic manipulation;Glioblastoma;Hydrocarbons;improved;in vivo;Induction of Apoptosis;inhibitor;innovation;Invaded;kinase inhibitor;knock-down;Knockout Mice;Label;Laboratories;Lead;leupaxin;Libraries;Ligands;Lymphangiogenesis;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;Measures;Mediating;Melanoma;Melanoma Cell;Mesenchymal;meter;migration;Morphologic artifacts;mutant;Mutation;myristoylation;N-terminal;Neoplasm Metastasis;Normal Cell;novel;novel therapeutics;Oncogenic;Oral;Ovarian;overexpression;Pancreas;Pathway interactions;paxillin;peptide drug;peptidomimetics;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Phase I/II Clinical Trial;Phosphotransferases;PI3K/AKT;Proliferating;Protein Isoforms;protein protein interaction;Protein Tyrosine Kinase;Proteins;recruit;Regional Cancer;Reporting;Research;Research Project Grants;response;Role;scaffold;Scaffolding Protein;screening;Series;Signal Pathway;Signal Transduction;small molecule;Solid Neoplasm;stapled peptide;System;targeted cancer therapy;targeted treatment;Technology;Tertiary Protein Structure;Testing;Therapeutic;Transfection;tumor growth;tumor progression

PROJECT_TITLE: Discovery of PPI inhibitors for the FAK FAT domain


NIH_SPENDING_CATS: Aging;Cancer;Cardiovascular;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Health Services;Heart Disease;Prevention

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE The goal of this proposal is to identify optimal strategies for primary prevention of cardiovascular disease (CVD) for survivors of breast (BC), prostate (PC) and lung (LC) cancer by developing and validating a novel Integrated Multi-Ethnic Cancer model (IMEC) to incorporate the development, progression, and outcomes of CVD among a diverse population of BC, PC and LC survivors. We will then assess the effectiveness and cost- effectiveness (CE) of different primary CVD prevention strategies for this large group of cancer survivors (>6 million in the US). The study will be innovative in applying state-of-the-art modeling approaches to evaluate primary CVD prevention strategies in a diverse population of cancer survivors, an understudied group at risk for poorer outcomes, and our results will have direct implications for the management of large numbers of cancer survivors and guide patient decision-making.

PI_NAMEs: KONG, CHUNG YIN ;LIN, JENNY J.;WISNIVESKY, JUAN P (contact)

PROGRAM_OFFICER_NAME: SHELBURNE, NONNIEKAYE F

PROJECT_TERMS: Affect;Aspirin;Atherosclerosis;Attenuated;Biochemical;Breast;Calcium;Calibration;Cancer Model;cancer recurrence;cancer risk;Cancer Survivor;cancer therapy;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;Cardiovascular system;Cause of Death;Cessation of life;chemotherapy;chest computed tomography;Clinical Trials;cohort;comorbidity;comparative effectiveness;computed tomography screening;coronary calcium scoring;cost effectiveness;Cost Effectiveness Analysis;Data;data harmonization;Decision Making;Development;Disease Outcome;effectiveness evaluation;ethnic minority;General Population;Genetic;Genetic Risk;genetic risk factor;Goals;Guidelines;High Prevalence;Hyperlipidemia;Hypertension;improved;in silico;Incidence;innovation;Life;Lipids;low dose computed tomography;Lung;Malignant Neoplasms;men;Methods;Modeling;models and simulation;Morbidity - disease rate;mortality;multi-ethnic;Natural History;novel;Outcome;Patients;polygenic risk score;Population;population based;Population Heterogeneity;Populations at Risk;Prevention strategy;Preventive care;Primary Prevention;Prostate;Quality of life;Quality-Adjusted Life Years;racial minority;Radiation therapy;Randomized, Controlled Trials;Recommendation;Recurrence;Regional Disease;Risk;Risk Factors;Risk Reduction;sex;simulation;Source;Stratification;Survivors;targeted treatment;Testing;Treatment-Related Cancer;United States;Woman;Women's mortality

PROJECT_TITLE: Modeling Best Approaches for Cardiovascular Disease Prevention in Cancer Survivors

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative  Oxidative nickel compounds are well-established human lung carcinogens. This proposal aims to investigate the functional role of N6-methyladenosine (m6A) and its demethylase ALKBH5 in nickel-induced malignant transformation and lung carcinogenesis. The success of this research proposal will significantly improve our understanding of the mechanism of nickel lung carcinogenicity and provide new aspects on m6A demethylase as a prognostic biomarker or therapeutic target to improve clinical outcomes of lung cancer.

PI_NAMEs: SUN, HONG  (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Address;Anchorage-Independent Growth;base;Binding Proteins;bronchial epithelium;cancer cell;Cancer Patient;carcinogenesis;carcinogenicity;Carcinogens;cell transformation;Cells;Clinical;DNA Methylation;Down-Regulation;Ectopic Expression;Environmental Exposure;Environmental Impact;Enzymes;epidemiology study;Epigenetic Process;Epithelial Cells;epitranscriptome;Event;Exhibits;Exposure to;Genes;histone modification;Human;imprint;improved;In Vitro;Incidence;insight;knock-down;Lung;lung carcinogenesis;Lung Neoplasms;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Messenger RNA;methyl group;Methylation;Methyltransferase;Modification;Monitor;mRNA Expression;mRNA Stability;Nickel;Nose;Nude Mice;Occupational Exposure;Outcome;Phenotype;Play;Prognostic Marker;protein expression;Proteins;Reporting;Research Proposals;response;RNA;RNA metabolism;RNA methylation;RNA Splicing;RNA Stability;RNA-Binding Proteins;Role;Series;Signal Transduction;Stress;success;therapeutic target;transcriptome;Translations;tumor;Tumor Suppressor Genes;tumor xenograft;Tumorigenicity;Up-Regulation

PROJECT_TITLE: ALKBH5 and nickel-induced lung carcinogenesis

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


NIH_SPENDING_CATS: Asthma;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Diabetes;Lung;Maternal Health;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

PHR: Asthma is common in childhood and a growing body of evidence suggests that metabolic derangements during pregnancy play a role in asthma inception. Diabetes during pregnancy has the potential to have lifelong effects on child respiratory and immune health through associated systemic inflammatory, immunologic, or oxidative stress changes that influence the developing pulmonary or immune system of the fetus. The aims of this study will be met by allowing the candidate to mentor new clinical investigators in patient-oriented research and conduct studies of prenatal risk factors for asthma, including prenatal diabetes, in a research program that serves to delineate risks factors and mechanisms of disease for asthma prevention.

PI_NAMEs: CARROLL, KECIA NICOLE (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: Academic Medical Centers;Address;Adult;Age;Anti-Inflammatory Agents;Antioxidants;Asthma;asthma prevention;Award;Board Certification;Body mass index;Breast Feeding;career;Child;Child Health;Childhood;Childhood Asthma;Chronic;Classification;Clinical Data;Clinical Investigator;Clinical Research;clinical translation;cohort;comorbidity;cost efficient;Data;Data Sources;Development;Diabetes Mellitus;Disease;Disease Outcome;Effectiveness;Electronic Health Record;Environment;Epidemiologist;experience;Exposure to;Faculty;Fellowship;Fetus;Fostering;Funding;Future;Gestational Age;gestational weight gain;Growth;high risk;immune health;Immune system;Immunologics;in utero;Infant;Inflammatory;interest;Investigation;K-Series Research Career Programs;Lead;Life;Link;Lung;lung health;maternal diabetes;Mentors;Metabolic;mid-career faculty;Midcareer Investigator Award in Patient-Oriented Research;Morbidity - disease rate;Mothers;National Institute of Allergy and Infectious Disease;novel;Nutritional;offspring;Outcome;Oxidative Stress;patient oriented;patient oriented research;pediatrician;Pediatrics;Play;Policies;Pregnancy;prenatal;prenatal exposure;prenatal risk factor;prepregnancy;prepregnancy obesity;Prevention;programs;prospective;Prospective cohort;Prospective Studies;Publications;pulmonary function;Pulmonology;recruit;Research;Research Design;Research Personnel;respiratory health;response;Risk;Risk Factors;Role;secondary analysis;Site;skills;smoking during pregnancy;Time;Training;translational study;traumatic stress;Universities;Wheezing

PROJECT_TITLE: Midcareer Investigator Award in Patient-Oriented Research in Pediatric Asthma

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Lymphatic Research;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BALTIMORE

ORG_NAME: HUGO W. MOSER RES INST KENNEDY KRIEGER

ORG_STATE: MD

PHR: Our overall goal is to develop and optimize several clinically translatable MRI schemes that can non- invasively detect cerebrospinal fluid (CSF) water exchange in brain and apply them as potential MRI biomarkers for the early-stage Alzheimer’s disease. These include a molecular imaging method, dynamic glucose-enhanced (DGE) imaging, as well as a set of spin-labeling based MRI methods, named magnetization transfer indirect spin labeling and phase alternate labeling with null recovery. The new methods can be translated to other neurodegeneration diseases such as multiple sclerosis, Huntington’s disease, and Parkinson’s disease.

PI_NAMEs: XU, JIADI  (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: abeta deposition;absorption;Acetazolamide;Age;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer’s disease biomarker;Amyloid beta-Protein;amyloid imaging;Animal Disease Models;Animals;Appearance;aquaporin 4;Biological Markers;Brain;brain parenchyma;cerebral atrophy;Cerebrospinal Fluid;Circulation;Clinical;clinical translation;Contrast Media;Data;Dementia;Dependence;Deposition;Development;Diagnostic;Diffusion;Disease;early detection biomarkers;Etiology;Evaluation;fluid flow;Fluids and Secretions;Foundations;Gadolinium;Glucose;glymphatic dysfunction;glymphatic system;Goals;Human;Huntington Disease;Image;Image Enhancement;imaging modality;Impaired cognition;In Situ;in vivo;Infusion procedures;Injections;Intercellular Fluid;Intrathecal Injections;Intravenous;Knockout Mice;Label;Liquid substance;longitudinal design;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measurement;Measures;Meninges;Methods;mild cognitive impairment;molecular imaging;Monitor;Motion;mouse model;Multiple Sclerosis;Mus;Names;Nerve Degeneration;neurofibrillary tangle formation;Neurofibrillary Tangles;neuropathology;Neurotic Disorders;Non-Invasive Detection;older adult;Parkinson Disease;Pathology;Patients;Perfusion;perivascular channels;Persons;Phase;Physiologic pulse;Process;Property;protein aggregation;Proteins;rapid technique;Recovery;Scheme;Senile Plaques;Signal Transduction;Spin Labels;System;Techniques;Therapeutic;Time;Tissues;Tracer;Translating;Vasopressins;wasting;Water;Wild Type Mouse

PROJECT_TITLE: Cerebrospinal fluid exchange in Alzheimer's disease characterized by advanced MRI techniques

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Project Narrative ApoE is the strongest genetic risk factor for Alzheimer’s disease for unclear reasons. We have found that the pathway which regulates cholesterol metabolism also regulates the lipid content and release of ApoE from astrocytes in the brain. Better understanding how the different ApoE types are impacted by inhibiting this pathway could lead to better strategies for preventing or treating Alzheimer’s disease in the future.

PI_NAMEs: FERRIS, HEATHER  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Abeta synthesis;Address;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Anticholesteremic Agents;Apolipoprotein E;apolipoprotein E-2;apolipoprotein E-3;apolipoprotein E-4;arm;Astrocytes;Automobile Driving;Behavior;Brain;Cell Death;Cell Physiology;Chemicals;chemoproteomics;Cholesterol;Cholesterol Homeostasis;Cholesterol Synthesis Inhibition;Complement 1q;conditional knockout;Confocal Microscopy;Data;Drops;Enzyme-Linked Immunosorbent Assay;Ethidium;experimental study;Flow Cytometry;Future;Genetic;genetic risk factor;Genetic Suppression;Genotype;Human;improved;in vivo;Individual;inhibitor;Interleukin-1 alpha;Knock-in Mouse;Knock-out;Late Onset Alzheimer Disease;Link;Lipids;Measures;Mediating;Membrane Biology;Membrane Microdomains;mevalonate;mouse model;Mus;neuron loss;neuronal survival;Neurons;novel strategies;novel therapeutics;particle;Pathway interactions;Pharmacology;Phenotype;prenylation;preservation;prevent;Prevention;Production;Protein Isoforms;Protein Isoprenylation;Protein Secretion;Proteins;Regulation;Risk;Role;Saturated Fatty Acids;Senile Plaques;Serum-Free Culture Media;small hairpin RNA;superresolution imaging;Techniques;Testing;Therapeutic;TNF gene;tool

PROJECT_TITLE: Mevalonate Pathway Regulation of Astrocyte ApoE

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG-R]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Nutrition;Obesity;Prevention;Women's Health Research

ORG_DEPT: PATHOLOGY

PHR: Project Narrative We have discovered that non-alcoholic fatty liver disease (NAFLD) promotes breast cancer liver metastasis, probably by providing hepatocyte-derived lipids as an energy source for tumor growth. Our goal is to determine if prevention of NAFLD retards liver metastasis and the mechanisms by which hepatocyte-derived lipids are transferred to tumor cells and promote their growth. If as our preliminary data suggest, our observations extend to patients, prevention and cure of NAFLD will be a priority in those with potentially metastatic cancer.

PI_NAMEs: TEITELBAUM, STEVEN L (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: Acceleration;Address;Adipose tissue;Affect;American;breast cancer metastasis;Breast Cancer Patient;Breast Cancer Risk Factor;breast cancer survival;Breast Cancer Treatment;Calories;cancer cell;Cancer Prognosis;chemotherapy;Data;Disseminated Malignant Neoplasm;Early treatment;Energy-Generating Resources;Environment;Enzymes;Event;Exhibits;Fatty Acids;Fatty Liver;fatty liver disease;glucose metabolism;Goals;Grant;Growth;Health;Hepatic;Hepatocyte;High Fat Diet;Histology;Human;Immune;improved;Intake;Lipids;Lipolysis;Liver;liver biopsy;Macrophage;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Metabolic;Metabolic syndrome;Metastasis Induction;Metastatic breast cancer;Metastatic Neoplasm to the Liver;Mitochondria;Modeling;Mus;Neoplasm Metastasis;neoplastic cell;non-alcoholic fatty liver disease;Obesity;oxidation;Patients;Phenotype;Predisposition;prevent;Prevention;Probability;Process;Prognosis;Property;Resistance;response;Role;Site;Societies;targeted treatment;Therapeutic;Tissue Transplantation;Triglycerides;tumor;Tumor Burden;tumor growth;tumor microenvironment;Tumor Promotion;Tumor-associated macrophages;Weight;Woman;women's diagnosis

PROJECT_TITLE: Hepatic steatosis promotes liver metastasis

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Pediatric;Prevention;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE This K99/R00 proposal will investigate longitudinal trajectories and social mechanisms of depression in adolescent girls with ASD. The studies will characterize momentary and cumulative social and emotional experiences in adolescent girls with ASD and identify risk and protective social-emotional factors relevant to depressive symptoms. Findings will have direct implications for designing ecologically valid prevention and treatment strategies for depression in ASD.

PI_NAMEs: ZHENG, SHUTING  (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Acceleration;Adolescence;Adolescent;adolescent mental health;adolescent with autism spectrum disorder;Age;autism spectrum disorder;Behavioral;boys;Characteristics;Clinical;completed suicide;Coping Skills;Data;Data Analyses;Data Collection;depression prevention;depressive symptoms;design;Development;Diagnosis;early adolescence;Ecological momentary assessment;effective intervention;emotion regulation;Emotional;emotional experience;emotional factor;Emotions;Ensure;Equation;experience;Female;Female Adolescents;Friendships;girls;Goals;high risk;Impairment;Individual;individualized medicine;individuals with autism spectrum disorder;Institution;interest;Intervention;Learning;Life;Loneliness;Longitudinal Studies;male;Maps;Measurement;Measures;Mental Depression;Mental disorders;Mental Health;Mentors;Methodology;Methods;Modeling;Mood Disorders;mood symptom;Moods;Motivation;National Institute of Mental Health;negative mood;novel;Pattern;peer victimization;Phase;Population;Positioning Attribute;Prevention;Prevention strategy;programs;protective factors;Protocols documentation;Psychological Impact;Psychopathology;psychosocial;Puberty;Reporting;Research;Research Activity;Research Personnel;Resources;Risk;Risk Factors;Sampling;sex;skills;social;Social Interaction;social relationships;Strategic Planning;success;Symptoms;Techniques;therapy development;Time;Training;Training Activity;treatment strategy;Vulnerable Populations;Well in self

PROJECT_TITLE: Tracking Depression and Associated Modifiable Social-Emotional Factors in Adolescent Girls with Autism


NIH_SPENDING_CATS: Immunotherapy;Kidney Disease;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_DEPT: SURGERY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative  A cornerstone of several common therapies for human diseases is the use of a vein as a conduit to increase blood flow such as the arteriovenous fistula, the preferred access for hemodialysis. However, fistulae have extremely high rates of both early and late failure, and these poor clinical results lead to patient suffering and extensive expenditure of precious healthcare dollars and other resources for additional re-do procedures and surgery. The work to be accomplished within this proposal addresses the knowledge gap in the biology of venous remodeling that has created a serious unmet need for novel approaches to enhance venous adaptation to the fistula environment and enable successful long-term use of venous conduits in both women and men.

PI_NAMEs: DARDIK, ALAN  (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: adaptive immune response;adaptive immunity;Address;Affect;Age;Arteriovenous fistula;Biology;Blood flow;Blood Vessels;Cell Physiology;Cells;Chronic Kidney Failure;Clinical;clinical translation;Clinical Trials;Cyclosporine;Data;Encapsulated;End stage renal failure;Environment;Expenditure;experience;Failure;Female;Fistula;Gonadal Steroid Hormones;Healthcare;Hemodialysis;hemodynamics;Hormones;Human;human disease;Hyperplasia;Immune;Immune response;improved;in vivo;in vivo Model;Innate Immune Response;innovation;Intervention;Investigation;Knowledge;Legal patent;local drug delivery;Macrophage;male;Mechanics;Mediating;men;Methodology;Modeling;mouse model;Mus;nanoparticle;Needles;Nephrectomy;next generation;novel;novel strategies;Operative Surgical Procedures;Outcome;Patients;Persons;Physiology;Pregnancy;Procedures;programmed cell death ligand 1;Puncture procedure;Resources;response;Role;Sex Differences;sexual dimorphism;shear stress;Specimen;T cell therapy;T-Lymphocyte;Techniques;Testing;Thick;tool;transcriptomics;Vein graft;Veins;Venous;Woman;Work

PROJECT_TITLE: Adaptive immunity regulates arteriovenous fistula remodeling

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Antibiotic-resistant bacterial infections pose a major threat to human health. This project establishes methods to study assembly of the bacterial cell wall and uses them to characterize newly discovered antibacterial targets. These studies may lead to the discovery of antibiotics to treat resistant infections.

PI_NAMEs: KAHNE, DANIEL ;WALKER, SUZANNE  (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Acceleration;amidase;Anabolism;analog;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;Bacteria;Bacterial Antibiotic Resistance;bacterial genetics;Bacterial Infections;bacterial resistance;beta-Lactams;Binding;Biochemical;Biochemistry;Biological;Biological Assay;Cell division;Cell membrane;Cell Separation;Cell surface;Cell Wall;Cells;Cellular biology;Chemicals;Collaborations;Collection;Complex;crosslink;Cytoplasm;daughter cell;design;Development;Enzymatic Biochemistry;enzyme structure;Enzymes;Family;Foundations;genetic approach;Glean;Glucosaminidase;Glycopeptides;Goals;Grant;Health;high throughput screening;Human;Hydrolase;In Vitro;Infection;inhibitor;insight;Knowledge;Learning;Letters;Lipids;Membrane Potentials;Membrane Proteins;Methods;Molecular Conformation;muramyl-NAc-(pentapeptide)pyrophosphoryl-undecaprenol;mutant;Nature;novel;novel strategies;Organism;Pathogenesis;Pathway interactions;Peptidoglycan;Peptidyltransferase;Physiology;Play;Polymerase;Polymers;Process;programs;protein complex;Proteins;Publishing;reconstitution;Recording of previous events;Research;Research Support;Resistance;response;Role;Staphylococcus aureus;Staphylococcus aureus infection;Structure;technological innovation;tool;Vancomycin;Variant

PROJECT_TITLE: Discovery and characterization of new bacterial cell wall targets and inhibitors to treat resistant infections

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]