NIH_SPENDING_CATS: Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: OLSON, JESSICA M (contact)

PROJECT_TERMS: 2 arm randomized control trial;Address;adverse maternal outcomes;adverse outcome;Advocate;African American;American;Attitude;Birth;Black Populations;Black race;black women;Breast Feeding;Censuses;Cesarean section;Cities;Clinical;Communities;community advisory board;community engagement;Community Health;community partnership;compare effectiveness;Complex;County;Data;Death Rate;Discipline of obstetrics;Disparity;Education;Emotional;experience;Family;Feedback;First Pregnancy Trimester;Focus Groups;Frequencies;Health;health care availability;health care service organization;health disparity;Health Personnel;Health Professional;Health system;Healthcare;Healthcare Systems;Hospitals;improved;Inequity;Infant Health;Interview;Maternal Health;maternal morbidity;Maternal-fetal medicine;Measures;Medical;Mental Health;Methods;Midwife;model building;Modeling;Morbidity - disease rate;Mothers;multidisciplinary;Municipalities;Needs Assessment;Not Hispanic or Latino;Nurses;Occupational;Outcome;Participant;Patients;perceived discrimination;Perinatal;Persons;Play;Policies;Policy Maker;Postpartum Depression;Postpartum Period;Pregnancy;pregnant;Premature Birth;prenatal;Prenatal care;prenatal health;primary outcome;programs;Provider;Qualitative Research;racial disparity;Randomized;Reaction;Recommendation;Reporting;Research;Resources;Risk Factors;Role;secondary outcome;segregation;severe maternal morbidity;social;social structure;Social Workers;Source;structural determinants;Surveys;symposium;System;Testing;therapy development;Trust;Vaccination;Visit;White Women;Wisconsin

PROJECT_TITLE: Building TrUst and UNiting Teams Through DouLa partnErship-BUNDLE


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Hematology;Microbiome;Nutrition;Orphan Drug;Prevention;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Graft-versus-host disease (GvHD) is a common complication of allogeneic hematopoietic cell transplantation (HCT) associated with substantial morbidity and mortality. GvHD has been linked to loss of gut bacterial diversity and changes in bacterial community composition that commonly occur after HCT. This study seeks to determine the optimal method for restoring gut bacterial diversity using fecal microbiota transplantation from normal donors and supplemental dietary fiber, with the ultimate goal of advancing our understanding of mechanisms for microbe-mediated attenuation of GvHD.

PI_NAMEs: FREDRICKS, DAVID NEAL (contact);HOCKENBERY, DAVID M.

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Activities of Daily Living;Acute;Affect;Allogenic;Animals;Antibiotics;Area;attenuation;Bacteria;bacterial community;beneficial microorganism;Bile Acids and Salts;Biological;Biology;Blood;Blood Flow Cytometry;burden of illness;Butyrates;capsule;Carbohydrates;Cells;Clinical;Clinical Data;Clostridium difficile;Colon;Colonoscopy;Complication;Coupled;Data;design;Diarrhea;Diet;Diet Surveys;dietary;Dietary Fiber;Dietary intake;Dietary Supplementation;Disease Outcome;disorder risk;efficacy trial;Engraftment;Enteral Nutrition;Environment;Exposure to;fecal microbiome;fecal transplantation;Feces;Fermentation;Fiber;Flow Cytometry;follow-up;Fostering;Frequencies;functional loss;Future;Gastric Acid;gastrointestinal;Genes;Goals;graft vs host disease;gut bacteria;gut colonization;gut health;gut microbiome;gut microbiota;healing;Health;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;High Prevalence;high risk;Human;ileum;Immune;Immunity;Immunologics;immunoregulation;Immunosuppressive Agents;Impact evaluation;improved;Injury;insight;Intervention;Intervention Studies;Intestines;Investigation;leukemia;Life;Link;liquid chromatography mass spectrometry;Liquid substance;Mass Spectrum Analysis;Measures;Mediating;Metabolic;Metabolism;metagenomic sequencing;Metagenomics;Methods;Microbe;microbial;microbial colonization;microbiome;microbiota;microbiota composition;Morbidity - disease rate;mortality;Mucosal Immune System;next generation sequencing;Nutrient;Nutritional;Observational Study;Oral;Oral Administration;Outcome;Participant;Patients;Pharmaceutical Preparations;Physiology;Pilot Projects;Population;prebiotics;primary endpoint;Production;Publishing;Quality of life;Randomized;Randomized, Controlled Trials;reconstitution;Recovery;recruit;Regulatory T-Lymphocyte;Reporting;Research Personnel;Resolution;Risk;Role;Route;rRNA Genes;safety outcomes;sample collection;secondary endpoint;Shapes;stool sample;Supplementation;Surveys;Symptoms;T-Lymphocyte Subsets;Testing;Transplant Recipients;Transplantation;transplantation therapy;treatment choice;Uncontrolled Study;Volatile Fatty Acids

PROJECT_TITLE: Fecal Microbiota Transplantation and Fiber for the Treatment of Graft-versus-host Disease After Hematopoietic Cell Transplantation

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Cyanide poisoning and Leigh syndrome are both related conditions involving major neurological consequences, mitochondrial dysfunction and redox imbalance. Because of the limitations and/or lack of treatment for both, studies establishing the therapeutic value of restoring redox balance will advance drug development for both.

PI_NAMEs: TIPPETTS, EMILY  (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Affect;Aftercare;Age;alternative treatment;Antidotes;Association Learning;Behavioral;Binding;Biological Assay;Birth;Brain;cell injury;Cells;Characteristics;cofactor;Collection;Complex;complex IV;conditioning;Consumption;Cyanides;Cytosol;Deacetylase;Deacetylation;design;Disease;disease phenotype;disease-causing mutation;drug development;effective therapy;electron donor;Electron Transport;Electrons;Equilibrium;experimental study;extend lifespan;Family suidae;Functional disorder;Genes;Genetic;Genus Hippocampus;glyoxylate;Homeostasis;Human;Immunohistochemistry;improved;improved outcome;Industrial Accidents;inhibitor;Inner mitochondrial membrane;Intraperitoneal Injections;Investigation;Knock-out;Leigh Disease;Link;Locomotion;Metabolic;metabolic poison;Metabolism;Mitochondria;Mitochondrial Diseases;mitochondrial dysfunction;Modeling;Monitor;Motion;mouse model;Mus;Mutate;Mutation;NADH;NADH oxidase;Neurologic;Neurological outcome;Nicotinamide Mononucleotide;Oryctolagus cuniculus;oxidation;Oxidation-Reduction;Oxygen Consumption;Patients;pharmacologic;Phenotype;Poisoning;prevent;Production;protein complex;Protons;Reaction;restoration;Risk;Role;sensor;Sirtuins;smoke inhalation;Syndrome;Technology;Therapeutic;Time;Tissues;Toxic effect;Zebrafish

PROJECT_TITLE: The role of redox balance in cyanide toxicity and mitochondrial disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Prevention

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PI_NAMEs: PECK, JENNIFER DAVID (contact)

PROJECT_TERMS: Address;Adoption;American Indian Tribe;analytical method;analytical tool;Applications Grants;Applied Research;Biometry;Biostatistical Methods;Clinical;clinical care;Clinical Informatics;Clinical Research;Clinical Sciences;Clinical Skills;Collaborations;Communities;community based research;Community Health;community partners;Computerized Medical Record;computerized tools;computing resources;Consult;Data;Data Analyses;Data Collection;data quality;Data Set;Data Sources;data visualization;Degree program;design;Diagnostic Procedure;Discipline;Disease;Dissemination and Implementation;Educational workshop;Effectiveness;Ensure;Epidemiologic Methods;Epidemiologic Research Design;Epidemiology;Extramural Activities;Faculty;Funding;Grant;Growth;Health;health assessment;health data;health organization;Health Professional;implementation study;improved;Informatics;Infrastructure;innovation;Institution;instrument;intervention program;Laboratory Research;Learning;Maintenance;Master of Science;Measurement;Medical;member;Methodology;Methods;Mission;Multimedia;novel;novel strategies;Oklahoma;Patients;Peer Review;Personal Satisfaction;Population;population health;preclinical study;Prevention strategy;Process;Productivity;programs;Publications;Qualitative Research;Quality Control;Randomized Controlled Clinical Trials;Recommendation;Reporting;Reproducibility;Research;Research Design;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;research study;Research Support;Resources;Risk Factors;Sample Size;Science;skills;Source;Statistical Methods;Students;success;Surveys;Techniques;Therapeutic;tool;Training;Translational Research;translational scientist;translational study;treatment strategy

PROJECT_TITLE: Biostatistics, Epidemiology, and Research Design Core


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: ATLANTA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: MOREHOUSE SCHOOL OF MEDICINE

ORG_STATE: GA

PHR: Narrative Developed through a partnership among the Morehouse School of Medicine (an HBCU committed to social justice and health equity), Emory University (an R1 university with a strong record of maternal and behavioral health research), and a host of community partners, the mission of the Center to Advance Reproductive Justice and Behavioral Health among Black pregnant/postpartum women (CORAL) is to help Black women survive and thrive while pregnant and postpartum, by translating maternal behavioral health research into multilayered action with communities. CORAL will achieve its mission by developing and sustaining a robust transdisciplinary community-drive research infrastructure; conducting rigorous, ethical transdisciplinary research in partnership with communities; building the capacity of the next generation of investigators; and collaborating with academic, governmental, and community to disseminate and translate discoveries.

PI_NAMEs: COOPER, HANNAH LF;DUNLOP, ANNE LANG;HERNANDEZ, NATALIE DOLORES (contact)

PROGRAM_OFFICER_NAME: FABIYI, CAMILLE

PROJECT_TERMS: Address;Affect;Anxiety;behavioral health;Birth;Black race;black women;Caring;Centers of Research Excellence;Childbirth;Clinical;Collaborations;Communities;community engagement;Community Networks;community organizations;community partners;community partnership;coral;Country;Death Rate;Development;Discrimination;effective intervention;Epidemic;Equity;Ethics;Exclusion;experience;Gender Identity;Generations;Goals;Grant;health equity;Income;Individual;Infrastructure;innovation;Institution;Intention;Intervention;Justice;Language;Lived experience;Maternal Health;maternal morbidity;Maternal Mortality;Mental Health;Mission;Modeling;Morehouse School of Medicine;neglect;next generation;Overdose;Perinatal;Persons;Post-Traumatic Stress Disorders;Postpartum Depression;Postpartum Period;Postpartum Women;Pregnancy;Pregnancy Complications;pregnant;Pregnant Women;programs;Public Health;reproductive;Research;Research Infrastructure;Research Personnel;Research Project Grants;Review Committee;Scientist;Site;Social Justice;Substance Use Disorder;technological innovation;Training;Translating;Translational Research;Underrepresented Minority;Universities;White Women;Woman;Work

PROJECT_TITLE: Center to Advance Reproductive Justice and Behavioral Health among Black Pregnant/Postpartum Women and Birthing People (CORAL).

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-F(71)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PROJECT_TERMS: Address;Adopted;adverse pregnancy outcome;Advocacy;African American;African American population;Area;Birth;Black race;Cancer Science;Cardiovascular Diseases;Caring;Centers of Research Excellence;Chronic Disease;Clinical;Communication;Communities;community academic partnership;Community Health Aides;community organizations;community partnership;community science;community setting;Complex;Continuity of Patient Care;Country;Data Collection;Death Rate;Dedications;design;Discipline;Disparity;Ensure;Equity;Ethnic Origin;Evaluation;Family;Federally Qualified Health Center;Feedback;Focus Groups;Goals;Government;Grant;Health;health care service organization;health disparity;Health Personnel;Health Professional;Healthcare;High-Risk Pregnancy;Home;Housing;housing instability;Hypertension;improved;Income;Individual;innovation;interdisciplinary collaboration;Knowledge;Low income;low socioeconomic status;Malignant Neoplasms;Maternal Health;maternal morbidity;Maternal Mortality;Medicaid;Medical;medical schools;meetings;member;Modeling;mortality risk;Outcome;outcome disparities;outreach;Participant;Patients;Persons;Policies;Policy Maker;Population;population health;postpartum care;Postpartum Period;Pregnancy;Pregnancy Complications;pregnancy disorder;prenatal;Preparation;Race;racial disparity;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resources;Risk Factors;Risk Reduction;Social Development;social health determinants;social structure;supported housing;symposium;System;Training;Trust;Wisconsin;Woman;Work

PROJECT_TITLE: Transdisciplinary and Equitable Approach to Maternal health (TEAM)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-F]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: RADER, JANET S. (contact)

PROJECT_TERMS: Academia;Address;Adherence;adverse outcome;Affect;Applications Grants;Benchmarking;Biomedical Research;Birth;career;Caring;Clinic;Clinical;Clinical Research;Clinical Trials;Clinical Trials Design;college;Communities;community engaged research;community engagement;community intervention;Conceptions;Conduct Clinical Trials;Data Collection;design;Development Plans;Educational Curriculum;effective therapy;Ensure;Equity;ethnic diversity;ethnic minority;Ethnic Origin;Evaluation;Exclusion;expectation;Extramural Activities;Faculty;Funding;Future;Goals;Grant;Health;health disparity;health training;higher education;improved;Individual;Institution;interest;Intervention;Lactation;Learning;Letters;Limited English Proficiency;Linguistics;Maternal Health;Maternal health equity;maternal morbidity;Maternal Mortality;Medical;medical schools;member;Mentors;Methodology;Morbidity - disease rate;mortality;Participant;Patient Outcomes Assessments;Performance;Persons;Physicians;Positioning Attribute;Postdoctoral Fellow;Postpartum Period;Pregnancy;Pregnancy Outcome;pregnant;Prevalence;Process;Program Evaluation;programs;prospective;Publications;Race;racial disparity;racial diversity;racial minority;racial population;Randomized;recruit;Research;Research Institute;Research Methodology;Research Personnel;Research Project Grants;resilience;Resources;Risk Factors;satisfaction;social health determinants;social media;social structure;socioeconomics;Structural Racism;success;Surveys;Testing;Training;Training Programs;Underrepresented Populations;United States;United States National Institutes of Health;Universities;urban area;Wisconsin;Writing

PROJECT_TITLE: Early Career-CeNtered EnricHment to AdvaNce Research Careers in Maternal HEalth  -ENHANCE-M


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Immunization;Infectious Diseases;Lyme Disease;Prevention;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: Narrative  Approximately 500,000 Americans contract Lyme disease and urgently require antibiotic therapy early in their infection to prevent irreversible damage to their joints, heart, and brain. The proposed research seeks to understand the basis of a patient’s inability to clear the bacterial infection and develop a sustained immune response that can provide protection from future reinfections. These results will also inform the development of potential biomarkers to improve diagnostic testing and glycoengineering of intravenous antibody therapy.

PI_NAMEs: COMUNALE, MARY ANN (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Acute;Acute Disease;American;Anti-Inflammatory Agents;Antibiotic Therapy;Antibodies;Antibody Therapy;antibody-dependent cell cytotoxicity;antibody-dependent cellular phagocytosis;Antigenic Variation;Antigens;B-Lymphocytes;Bacterial Infections;Binding;Biological Assay;Biological Markers;Borrelia;Borrelia burgdorferi;Borrelia burgdorferi Group;Brain;Cells;Clinical;clinical diagnostics;Complement;Complement 1q;Complement Activation;Complex;Contracts;COVID-19;Cytolysis;Data;Deposition;Development;diagnostic assay;Diagnostic tests;Disease;Early Diagnosis;Early treatment;Enzymes;Exoglycosidases;Fab domain;Fab Immunoglobulins;Fc domain;Fc Receptor;Functional disorder;Future;Galactose;Glycoengineering;glycosylated IgG;glycosylated IgM;glycosylation;Goals;Health;Heart;HIV;Human;Immune;Immune Evasion;Immune response;Immune signaling;Immune Targeting;Immunoglobulin Alterations;Immunoglobulin G;Immunoglobulin M;Immunoglobulins;Immunology procedure;immunoregulation;Impairment;improved;in vitro Assay;Incidence;Incubated;Infection;Inflammation;Inflammatory;Inflammatory Response;Intravenous;Intravenous Immunoglobulins;Joints;Label;Link;Lyme Disease;Lyme disease diagnosis;Lyme disease diagnostic;lyme pathogenesis;Masks;Measures;Mediating;Mucocutaneous Lymph Node Syndrome;Multiple Sclerosis;Nature;neutravidin;novel;Order Spirochaetales;Organ;pathogen;Patients;Pattern;Peptides;Polysaccharides;Population;Post-Translational Protein Processing;potential biomarker;prevent;receptor;Reporting;Research;response;Rheumatoid Arthritis;Role;Sampling;seroconversion;Serum;Serum Proteins;Sialic Acids;Signal Transduction;Solid;Structure of germinal center of lymph node;sugar;Testing;Tuberculosis;Work

PROJECT_TITLE: Immune Modulation During Acute Lyme Disease Infection as the Result of Aberrant Immunoglobulin Glycosylation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-M(90)]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

ORG_STATE: NY

PHR: NARRATIVE We will generate machine learning, predictive models designed to optimize patient monitoring, using large clinical datasets from diverse communities, providing clinicians with new tools to enable early, targeted, potentially life-saving therapies to hospitalized patients. We will develop these advanced prediction tools and a better understanding of these patient populations, using our large dataset from more than 2.4 million hospitalizations across multiple hospitals and a prospective cohort of 2,000 continuously monitored patients. These models can optimize patient monitoring, while reducing clinician workload, identify in advance patients likely to deteriorate and the underlying reasons of their deterioration to enable timely interventions.

PI_NAMEs: DAVIDSON, KARINA W.;ZANOS, THEODOROS  (contact)

PROGRAM_OFFICER_NAME: MCNAMARA, KAREN MARIE

PROJECT_TERMS: Address;Admission activity;Adult;Algorithms;base;Caring;Cessation of life;Clinical;Clinical Data;clinical predictors;Cluster Analysis;cohort;Communities;cost;Country;COVID-19 patient;Data;Data Set;deep learning model;design;Deterioration;Devices;Diagnosis;Diagnostic;diagnostic value;Electronic Health Record;Floor;Health;Health system;Heart Arrest;high risk;Hospitalization;Hospitals;Hour;improved;innovative technologies;Inpatients;Intensive Care Units;Intervention;Intubation;large datasets;learning strategy;Life;Link;Machine Learning;machine learning algorithm;machine learning prediction;Manuals;Measurement;Measures;Medical;model design;Modeling;Monitor;monitoring device;Morbidity - disease rate;mortality;multimodal learning;Natural Language Processing;Neural Network Simulation;Nurses;Operative Surgical Procedures;Outcome;Patient Admission;Patient Monitoring;patient population;Patient-Focused Outcomes;Patients;personalized care;Phenotype;prediction algorithm;predictive modeling;predictive tools;preventable death;prospective;Prospective cohort;Publishing;Recommendation;Recording of previous events;Recurrence;recurrent neural network;Research;Resources;response;Risk;Sleep;Specific qualifier value;Staff Work Load;support tools;Symptoms;Target Populations;targeted treatment;Time;tool;Training;treatment strategy;unsupervised clustering;unsupervised learning;Validation;vector;ward;wearable device;wearable monitor;Work;Workload

PROJECT_TITLE: Optimization of monitoring, prediction and phenotyping of deterioration of inhospital patients using machine learning and multimodal real time data

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: SPICER, PAUL G (contact)

PROJECT_TERMS: Address;adverse childhood events;Affect;Alaska Native;Arthritis;Attention;Award;Beds;burden of chronic illness;Cancer Center Planning Grant;cancer health disparity;cardiovascular health;career;Cherokee Nation;Chickasaw Nation;Choctaw Nation of Oklahoma;Chronic;Clinical;Clinical Research;Collaborations;Communities;community based research;community engaged research;community engagement;Community Health;Community Healthcare;community involvement;community organizations;Community Outreach;community partners;community research;community-centered;Contact Tracing;COVID-19 testing;Development;diabetes management;Diabetes Mellitus;disability;Disease;Dissemination and Implementation;Ethics;experience;Extramural Activities;Faculty;Fostering;Funding;Future;Genetic;Genomics;Grant;Growth;Health;health care delivery;Health care facility;health equity;health organization;Health system;Heart Diseases;implementation research;improved;Indigenous;Individual;Infant Mortality;information gathering;Infrastructure;Institution;Institutional Policy;Institutional Practice;interest;lung cancer screening;Malignant Neoplasms;Maternal Mortality;Minority Groups;Mission;Modeling;Native American Research Center for Health;NCI-Designated Cancer Center;Obesity;Oklahoma;Opioid;Outcome;pandemic disease;Patients;Pediatrics;Population Scientist Supplement (R25);practice-based research network;Preventive service;Primary Care;primary care practice;Primary Health Care;Productivity;Proliferating;Provider;Public Health;RADx Underserved Populations;Research;Research Personnel;Research Project Grants;Research Support;Resources;Rheumatism;Risk;Rural;Rural Community;rural healthcare;Rural Population;Science;screening;Series;South Dakota;Students;Substance abuse problem;success;Testing;Tobacco use;Training;Translational Research;tribal community;Tribal group;tribal health;tribal Nation;Tribes;Underrepresented Populations;Underserved Population;United States National Institutes of Health;uptake;vaccine hesitancy;Work

PROJECT_TITLE: Community Engagement and Outreach Core


ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PI_NAMEs: MCMANUS, DAVID D. (contact)

PROGRAM_OFFICER_NAME: CHEN, JUE

PROJECT_TERMS: Advisory Committees;Blood;Businesses;Clinical;Collaborations;commercialization;Communication;Communities;Community Health;Complex;Developmental Process;Device or Instrument Development;Diagnosis;Engineering;experience;Foundations;Funding;Goals;health equity;health organization;Health Personnel;Health system;Heart;Heart Diseases;Hematological Disease;Home;improved;Incubators;Industry;industry partner;International;Knowledge;Leadership;Lung;Lung Diseases;Massachusetts;Medical;Medical Device;medical schools;Modeling;novel;organizational structure;patient advocacy group;patient oriented;point of care;Point of Care Technology;Principal Investigator;product development;programs;RADx Tech;Research;Research Personnel;Resources;Role;Running;Services;Site;Sleep;Sleep Disorders;Structure;technological innovation;Technology;technology development;technology research and development;Testing;United States National Institutes of Health;Universities;usability;Validation;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Cooley's Anemia;Gene Therapy;Genetics;Hematology;Immunotherapy;Orphan Drug;Rare Diseases;Regenerative Medicine;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Sickle cell disease (SCD) and transfusion-dependent b-thalassemia (TDT) are severe blood disorders for which the only currently available curative therapies require chemotherapy, which comes with substantial short-term and long-term drawbacks. We have developed a novel approach where we produce base edits in blood stem cells to both re-activate therapeutic fetal hemoglobin and create cells resistant to immune-based therapies. Our premise to be tested is that this approach could allow the development of curative therapies for SCD and TDT that do not require chemotherapy (or radiation therapy), and thus sidestep inherent risks such as nausea, hair loss, mucositis, life-threatening infections, infertility, DNA damage, and cancer.

PI_NAMEs: BAUER, DANIEL EVAN (contact);GENOVESE, PIETRO

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Address;Affect;Allogenic;Amino Acids;Antigens;Autologous;Autologous Transplantation;base editing;beta Thalassemia;Biological Assay;Bone Marrow;Bone Marrow Purging;Bypass;Cell Transplantation;Cells;cellular engineering;chemotherapy;chimeric antigen receptor T cells;Clinic;Clinical;clinical efficacy;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;conditioning;Coupling;curative treatments;Cytokine Receptors;Data;Defect;derepression;Development;Disease;DNA Damage;Drug Kinetics;efficacy validation;Endowment;Engineering;Engraftment;Epitopes;Erythroid Cells;Extracellular Domain;Face;Fetal Hemoglobin;FLT3 gene;Future;Gene Modified;gene therapy;Gene Transfer;Genetic;Genetic Engineering;genome-wide;genotoxicity;Globin;Goals;Guide RNA;Hair;Hematological Disease;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hemoglobin;hemoglobin B;Hemoglobinopathies;Homologous Transplantation;Human;IL3RA gene;Immune;Immunotherapy;Immunotoxins;Infection;Infertility;Infusion procedures;innovation;Intervention;Life;Ligands;Malignant Neoplasms;manufacturing process;Measurable;Medical;Modeling;Modification;Monoclonal Antibodies;Mucositis;Nature;Nausea;new technology;novel strategies;nuclease;Parameter Estimation;Pathologic;Patients;Pharmaceutical Preparations;Physiological;Pre-Clinical Model;preservation;Production;protein function;Radiation therapy;receptor;Regimen;Regulation;research clinical testing;Resistance;response;Risk;scale up;Sickle Cell Anemia;sickling;Specificity;stem cell engraftment;System;Testing;Therapeutic;Therapeutic antibodies;Time;tool;Toxic effect;Transfusion;Translations;Transplantation;Treatment Efficacy;Validation

PROJECT_TITLE: Chemotherapy-free cure of hemoglobin disorders through base editing

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: AR

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: LOS ANGELES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Damage to the vascular endothelium is not only responsible for cardiovascular disease – the leading cause of mortality in patients with autoimmune diseases – but also implicated in the pathogenesis of idiopathic inflammatory myopathies (IIM). This study will investigate the possible link between vascular damage and dysfunctional pro-inflammatory HDL, which is known to promote lipid oxidation and perpetuate endothelial damage, in a longitudinal cohort of patients with IIM. Understanding how HDL function contributes to not only macrovascular damage but also microvascular damage in IIM could offer promise for emerging therapeutic targets to improve the lives of patients with IIM as well as other autoimmune diseases.

PI_NAMEs: BAE, SANGMEE  (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: Acceleration;Address;Affect;Anti-Inflammatory Agents;Antibodies;antioxidant enzyme;Antioxidants;Apolipoprotein A-I;Area;Arylesterase;Atherosclerosis;Autoimmune Diseases;biomarker panel;Blood Vessels;burden of illness;California;Cardiopulmonary;Cardiovascular Diseases;cardiovascular health;career development;cell injury;chest computed tomography;Cholesterol;circulating biomarkers;Clinical;cohort;Complex;Complication;Core Facility;Creatine Kinase;Data;Data Collection;Dermatomyositis;Dietary Intervention;Disease;Disease Outcome;disorder control;Endothelial Cells;endothelial dysfunction;Endothelium;Enzymes;fecal microbiome;fecal transplantation;follow-up;Foundations;Goals;gut microbiome;High Density Lipoproteins;Idiopathic Inflammatory Myopathies;Impairment;improved;Inflammatory;Institution;Interstitial Lung Diseases;Knowledge;Laboratories;Link;lipid mediator;Lipid Peroxides;Lipids;Longitudinal cohort;Los Angeles;Low-Density Lipoproteins;lung health;Measures;Mediating;Mediator;Mentors;Methods;microbial;microbial composition;microbiome;microbiome research;microbiota;Modification;mortality;mouse model;multidisciplinary;Neutrophil Infiltration;new therapeutic target;novel;novel therapeutics;Organ;Outcome Measure;oxidation;Oxidative Stress;particle;Pathogenesis;Patients;peptidomimetics;Peroxidases;Phospholipids;Physicians;prevent;Probiotics;Process;Progressive Disease;Property;Proteins;pulmonary vascular disorder;pulmonary vascular permeability;quantitative imaging;Research;Research Design;Resources;Rheumatoid Arthritis;Scientist;Severities;Standardization;Statistical Data Interpretation;stool sample;Subgroup;System;Systemic Lupus Erythematosus;Taxonomy;Techniques;Testing;therapeutic candidate;Therapeutic immunosuppression;therapeutic target;Time;Training;ultrasound;Universities;Vascular Diseases;Vascular Endothelium;vascular injury;Work

PROJECT_TITLE: Altered High-Density Lipoprotein function in Patients with Idiopathic Inflammatory Myopathies

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Hematology;Lung;Sleep Research;Social Determinants of Health

PI_NAMEs: HAFER, NATHANIEL SCOTT (contact)

PROJECT_TERMS: Address;Affect;Award;Blood;Businesses;Caregivers;Caring;Clinic;Clinical;Clinical Research;Collaborations;Collection;commercialization;Communities;community partners;cost;data integration;design;Development;Device or Instrument Development;Devices;Diagnosis;digital health;Engineering;Ensure;Evaluation;Funding;Goals;Grant;health care disparity;health disparity;health management;Health Sciences;Health system;Healthcare;Heart;Heart Diseases;Hematological Disease;Home;implementation science;improved;Incubators;Industry;Inpatients;Intellectual Property;Letters;Lung;Lung Diseases;Marketing;Massachusetts;Medical;Medical Device;medical schools;member;Minority Groups;Monitor;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Needs Assessment;new technology;novel;operation;Outcome;Patients;Performance;point of care;Point of Care Technology;Process;prototype;Provider;Quality of Care;Resource-limited setting;Resources;Services;Sleep;Sleep Disorders;sleep health;social health determinants;Source;success;technological innovation;Technology;technology development;Testing;tool;Underserved Population;Universities;usability;Validation;Work

PROJECT_TITLE: Technology Core


NIH_SPENDING_CATS: Bioengineering;Coronaviruses;Data Science;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: PITTSBURGH

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative The project will continue development of WESTPA software to power the next decade of rare- events research at any scale (e.g., molecular, cellular) via enhancements in performance and ease of use on high-performance clusters as well as cloud computing. The primary impact will be to facilitate simulations throughout the community at the frontiers in biology, making possible computations that otherwise would be out of reach for typical research groups. Research to be performed directly by the investigators will include studies of drug membrane permeability and viral infections with potential to enhance drug design efforts.

PI_NAMEs: CHONG, LILLIAN T (contact);ZUCKERMAN, DANIEL M

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: 2019-nCoV;Age;Algorithms;Amber;Biological;Biology;Budgets;Calcium;cell behavior;Cell Membrane Permeability;Cell model;Cells;Cloud Computing;Communities;computational platform;Computer software;Computers;conformational conversion;Coronavirus;Development;Diffusion;Documentation;Drug Design;Educational workshop;Effectiveness;Engineering;Environment;Equilibrium;Event;Family;flexibility;frontier;improved;Infrastructure;interoperability;Kinetics;machine learning framework;machine learning pipeline;Mathematics;Membrane;Methodology;model building;Modeling;Modernization;Molecular;molecular scale;next generation;Nuclear Pore Complex;outreach;parallelization;Pathologic;Pathway interactions;Peer Review;Performance;Persons;Pharmaceutical Preparations;Production;Proteins;Reaction;Research;Research Personnel;Ribosomes;Running;Sampling;Scheme;Scientist;Series;Silicon;simulation;software development;Software Tools;Statistical Computing;Stress Tests;supercomputer;Supercomputing;Testing;Time;Training;tutorial review;Vesicle;virtual;Virus Diseases

PROJECT_TITLE: WESTPA: A high-performance framework for simulating at the frontiers of biology

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Aging;American Indian or Alaska Native;Arthritis;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Patient Safety;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: SCOFIELD, ROBERT HAL (contact)

PROJECT_TERMS: Acceleration;Address;Adopted;American Indians;Area;Arthritis;Autoimmunity;Basic Science;biobank;Cardiovascular Diseases;career;Centers of Research Excellence;Certification;Cherokee Nation;Child Health;Childhood;Chronic;Clinical;Clinical Data;Clinical Informatics;clinical infrastructure;Clinical Investigator;Clinical Research;Clinical Trials;Clinical Trials Data Monitoring Committees;Clinical Trials Network;cohort;Collaborations;community engagement;community organizations;Community Outreach;Contract Services;Contracts;COVID-19;COVID-19 pandemic;COVID-19 testing;COVID-19 therapeutics;COVID-19 vaccine;Data;Data Analyses;data warehouse;Databases;Degenerative polyarthritis;Development;Diabetes Mellitus;Disease;Disease Outcome;Dissemination and Implementation;Effectiveness;Ensure;Feasibility Studies;Funding;Growth;Health;Human Resources;human subject;Human Subject Research;implementation research;improved;Individual;Informatics;informatics infrastructure;Infrastructure;innovation;Inpatients;Institution;Institutional Review Boards;Investigation;Investments;K-Series Research Career Programs;Learning;Life Expectancy;Malignant Neoplasms;Mediation;Medical;member;Mentors;minority communities;Minority Groups;minority health disparity;National Center for Advancing Translational Sciences;Native American Research Center for Health;new growth;Obesity;Oklahoma;Outcome;Participant;Patient Recruitments;Patients;Phase;Play;Population;population health;Post-Acute Sequelae of SARS-CoV-2 Infection;Process;programs;Protocols documentation;RADx Underserved Populations;recruit;Registries;repository;Reproducibility;Research;Research Activity;research facility;Research Personnel;Research Project Grants;Resources;response;Role;Rural;rural health disparities;Rural Minority;sample collection;Sampling;satisfaction;Scientist;Site;System;Therapeutic Intervention;therapeutic vaccine;Translational Research;translational scientist;tribal community;Tribes;Underrepresented Minority;United States Indian Health Service;United States National Institutes of Health;vaccine hesitancy;Variant;Viral;West Virginia;Work

PROJECT_TITLE: Clinical Resources Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Ovarian Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Project Narrative: The most lethal gynecologic malignancy in the US is ovarian cancer (OCa). Currently accepted standards of care for serous OCa patients include surgery and cytotoxic therapy. However, about 90% experience recurrence and eventually pass away from a disease that is chemo-resistant. This proposal aims to establish the significance of LIF/LIFR signaling in hypoxia-driven OCa therapy resistance and identify the mechanisms through which LIFR autocrine signaling contribute to chemotherapy resistance of serous OCa. The study has clinical relevance since it will clarify the role of the LIFR axis in the resistance to antiangiogenic therapy and chemotherapy in OCa and identify LIFR as a novel therapeutic target for the treatment of OCa. This F99/K00 award will also give me needed training for my academic career as a cancer researcher.

PI_NAMEs: EBRAHIMI, BEHNAM  (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: ABCG2 gene;Affect;Angiogenesis Inhibitors;Area;Ascites;autocrine;Autocrine Communication;Award;cancer cell;Cancer Patient;cancer recurrence;cancer stem cell;cancer therapy;career;Caring;cell growth;Cells;Cellular Metabolic Process;Chemoresistance;chemotherapy;Chemotherapy-Oncologic Procedure;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Colorectal Cancer;Complex;Conditioned Culture Media;cytokine;Cytotoxic Chemotherapy;Databases;Death Rate;Defense Mechanisms;Development;Disease;Disease Resistance;Doxorubicin;Epithelium;experience;Family;FRAP1 gene;Gene Expression;Genetic;Genomic approach;glycoprotein 130;Grant;Human;Hypoxia;Hypoxia Inducible Factor;Hypoxia-Responsive Elements;inhibitor;Interleukin-6;Knowledge;LIF gene;LIFR gene;Link;Maintenance Therapy;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;MAP Kinase Gene;Mediating;member;Mesenchymal;mouse model;new therapeutic target;Normal tissue morphology;Operative Surgical Procedures;Organoids;Ovarian;Pathway interactions;Patients;Phase;prevent;Proliferating;promoter;Proto-Oncogene Proteins c-akt;Publishing;Recurrence;Research;Research Personnel;Resistance;Resistance development;response;Role;Serous;Signal Pathway;Signal Transduction;standard of care;STAT3 gene;stemness;Stress;targeted treatment;Testing;Therapeutic;therapy resistant;Training;treatment response;tumor;tumor hypoxia;tumor microenvironment;tumor progression;Tumor Tissue;United States;vasculogenesis;Xenograft Model

PROJECT_TITLE: Targeting chemotherapy resistant high grade serous ovarian cancer


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research

ORG_NAME: AMERICAN ASSOCIATION FOR CANCER RESEARCH

PHR: Public Health This project is a pivotal initiative by the American Association for Cancer Research to address the challenges of minority underrepresentation in cancer research, to support an increasing number of minority investigators to contribute, thrive, and to gain health equity in the field of cancer research. Minority cancer researchers have many unique roles to play in cancer research, including adding a diverse voice to this field of study with the promise of producing innovation and mentoring opportunities for future minority students. One of the most important results of the program is to improve outcomes for minority and medically underserved patients. Minority research scientists have the potential to be more successful in balancing the diversity of clinical trial subjects and more successful in inspiring the trust of subjects. Because of sensitivity to cultures and even the locations of targeted populations, dedicated minority researchers also hold promise for succeeding with behavioral interventions that require outreach to minority communities.

PI_NAMEs: FOTI, MARGARET  (contact);HAIT, WILLIAM N.

PROGRAM_OFFICER_NAME: CALZOLA, JESSICA MARIE

PROJECT_TERMS: Achievement;Address;Advanced Malignant Neoplasm;American Association of Cancer Research;anti-cancer research;Area;Award;Awareness;Behavior Therapy;Caliber;Cancer Science;career;Career Choice;career development;Clinical;Clinical Trials;Collaborations;COVID-19 impact;Dedications;Development;Economics;Education;expectation;experience;Exposure to;field study;Funding;Funding Mechanisms;Future;Goals;Grant;Growth;Health Disparities Research;health equity;health inequalities;improved outcome;innovation;Institution;International;Knowledge;knowledge base;Learning;Location;Malignant Neoplasms;Medical Students;medically underserved;Medicine;meetings;Mentors;Minority;minority children;minority communities;Minority Graduate Student;Minority Groups;Minority Health Research;minority investigator;minority scientist;minority student;National Cancer Institute;Outcome;outreach;Patients;Play;Postdoctoral Fellow;programs;Public Health;Publications;Race;Research;Research Personnel;Role;Science;Scientist;skills;social;success;symposium;Target Populations;Time;Training;Travel;Trust;Underrepresented Minority;United States National Institutes of Health;Voice

PROJECT_TITLE: Young Minority Scientists in the Field of Cancer Research


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hematology;Infectious Diseases;Lung;Patient Safety;Sleep Research;Social Determinants of Health

PROJECT_TERMS: Acceleration;acute care;Address;Adherence;Adoption;advanced disease;Advisory Committees;Antigens;Blood;Caregivers;Chronic;Clinical;Clinical Research;Clinical Trials;Clinical Trials Data Monitoring Committees;Clinical Trials Network;clinically relevant;commercialization;Communication;Community Health Networks;community organizations;Competence;COVID-19;COVID-19 pandemic;COVID-19 test;Data;Data Collection;design;Device or Instrument Development;Devices;Diagnosis;digital;digital health;Disease Management;Elements;empowerment;Enrollment;Ensure;ethnic diversity;Evaluation;experience;Geography;Goals;Health;health equity;health equity promotion;health inequalities;Health Personnel;Health Promotion;Health system;Heart;Heart Diseases;Hematological Disease;Home;home test;improved;industry partner;Informatics;Infrastructure;innovation;Investments;Lung;Lung Diseases;member;Methods;Monitor;new technology;novel;operation;Participant;patient advocacy group;Patient Care;patient engagement;patient oriented;Patient Recruitments;Patients;point of care;Point of Care Technology;Practice Guidelines;pragmatic study;prevent;Process;Provider;Race;racial diversity;RADx Tech;Reporting;Research;Resource-limited setting;Resources;SARS-CoV-2 infection;Services;Sleep;Sleep Disorders;success;Technology;technology research and development;Testing;Time;tool;Translations;trial design;underserved community;United States National Institutes of Health;usability;Validation;validation studies;Work

PROJECT_TITLE: Clinical Core


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Immunotherapy;Infectious Diseases;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Public Health Relevance: Our specific aims are to identify the importance the immune-modulatory proteins PILRA and HVEM in herpes stromal keratitis (HSK). Understanding the role of these cellular receptors and how they contribute to the disease will provide insight for the development of novel therapeutics for the treatment of HSK, which is a frequent cause of corneal blindness in the US.

PI_NAMEs: LONGNECKER, RICHARD M (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Antibodies;Biological Assay;Blindness;Brain;Cell surface;Cell Surface Receptors;cell type;Cells;chemokine;Chronic;Clinical;clinically relevant;Cornea;corneal epithelium;corneal scar;cross reactivity;cytokine;Data;detection platform;Developed Countries;Development;Disease;Disease Progression;Event;Experimental Designs;Eye;Eye Infections;Flow Cytometry;Foundations;genital herpes;Glycoproteins;granulocyte;Herpes encephalitis;Herpes Labialis;Herpes Simplex Infections;Herpes stromal keratitis;Herpetic Keratitis;Human;Image;imaging system;Immune;immune activator;immune cell infiltrate;Immune response;Immune System Diseases;immune system function;Immunofluorescence Immunologic;Immunoglobulins;Immunomodulators;immunoregulation;Immunotherapy;in vivo;in vivo Model;Infection;Infiltration;Inflammation;Inflammatory;innovation;insight;Investigation;Knock-out;Knockout Mice;Lesion;Letters;Ligands;liquid crystal polymer;Lytic;Macrophage;Mediating;Mediator;Microglia;Modeling;monocyte;mouse model;multiplex assay;Mus;neovascularization;Neurons;novel;novel therapeutics;Oral cavity;Pathogenesis;pathology imaging;Patients;Phenotype;Primary Infection;Proteins;public health relevance;Publications;Publishing;PVRL1;receptor;Recurrence;Research;Role;Sampling;Signal Transduction;Simplexvirus;Skin;spectrograph;Structure of trigeminal ganglion;Swab;Symptoms;Syndrome;System;targeted treatment;Therapeutic;Therapeutic Intervention;time use;Tissues;Viral;Virus;Virus Diseases;Virus Replication;Visual impairment;Visualization

PROJECT_TITLE: Receptor Usage and Regulation of the Immune Response in HSV Infection

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health

PI_NAMEs: CAMPBELL, JANIS E (contact)

PROJECT_TERMS: Achievement;Address;American Indian Tribe;American Indians;Bibliometrics;Caliber;career;catalyst;Clinical;clinical data warehouse;Clinical Research;Clinical Trials;Collaborations;Communities;community engagement;Community Networks;community-centered;Data;Decision Making;Development;Disease;Effectiveness;Evaluation;Evaluation Research;Evaluation Studies;experience;Funding;Goals;Grant;Health;Health Priorities;Health system;Healthcare;High Prevalence;improved;Individual;Infrastructure;innovation;Institution;interest;Investments;Knowledge;Leadership;Learning;Logic;Measurement;Measures;Mentors;minority investigator;Mission;Modeling;Monitor;next generation;Oklahoma;Outcome;Outcome Measure;Participant;Pathway Analysis;peer learning;Pilot Projects;Population;Process;Process Measure;programs;Registries;repository;Research;Research Personnel;research to practice;Resource Allocation;Resources;Rural;satisfaction;Scientist;Services;Social Network;Strategic Planning;success;tool;Training;Training and Infrastructure;Training Programs;Translating;Translational Research;translational research program;tribal health;tribal organization;Underrepresented Minority;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Work

PROJECT_TITLE: Tracking and Evaluation Core


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Lung;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Acute lung injuries (ALI) are a leading cause of morbidity and mortality worldwide. After injury, the lung undergoes reparative processes and regulatory T cells (Tregs) are lymphocytes that play critical roles in lung repair, yet there is little mechanistic understanding of how Tregs are regulated and maintained within the lung. This work investigates the role of lung Tregs and how they are locally regulated and maintained, which would inform the design of new precision therapeutics to ameliorate ALI in humans.

PI_NAMEs: CHANG, ANTHONY  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: 3-Dimensional;Ablation;Acute Lung Injury;Acute Respiratory Distress Syndrome;Adipose tissue;allergic airway disease;Biological Response Modifiers;candidate identification;CD4 Positive T Lymphocytes;Cell Count;Cell Physiology;Cell Survival;Cells;Cellular biology;Coculture Techniques;Data Set;design;Development;differential expression;epithelium regeneration;experimental study;Fibroblasts;Flow Cytometry;Foundations;FOXP3 gene;GATA3 gene;Genetic;Goals;high dimensionality;Homeostasis;Human;Image;Immune;Immune response;immunoregulation;In Vitro;Inflammation;Inflammatory;Influenza A virus;Injury;insight;Integrins;intercellular cell adhesion molecule;Ligands;Location;Lung;Lung Diseases;lung injury;lung repair;Lymphocyte;Lymphoid;Maintenance;Measurement;Mediating;mesenchymal stromal cell;Microscopy;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;novel;Outcome;Pathway interactions;Pericytes;Play;Positioning Attribute;Precision therapeutics;Production;Proliferating;pulmonary function;Pyroglyphidae;receptor;Recovery;Regulation;Regulatory T-Lymphocyte;reparative process;Reporter;Role;Signal Transduction;single-cell RNA sequencing;Sorting;Stromal Cells;Structure of parenchyma of lung;Surface;System;T cell response;T-bet protein;T-Cell Proliferation;T-Lymphocyte Subsets;Testing;Th2 Cells;Therapeutic Uses;Thick;Tissues;transcriptome sequencing;TSLP gene;Vascular Cell Adhesion Molecule-1;Visceral;Work

PROJECT_TITLE: Defining a stromal niche for type 2-like lung regulatory T cells


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Clinical Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Microbiome;Nutrition;Obesity;Pediatric;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: HANOVER

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative The purpose of this renewal application is to provide scientific expertise and leadership to investigate new hypotheses while contributing critical data and biospecimens to address major gaps in our knowledge about early life environmental influences on child health and development in a US pregnancy cohort. Together, the unique strengths of our rural birth cohort and the national ECHO consortium will allow us to address health disparities, emerging public health crises, foster workforce diversity and ensure responsiveness of the program to a broad range of stakeholders.

PI_NAMEs: KARAGAS, MARGARET RITA (contact);MADAN, JULIETTE

PROGRAM_OFFICER_NAME: LAESSIG, SUSAN ALISON

PROJECT_TERMS: 2019-nCoV;3 year old;Address;Advisory Committees;Agriculture;Air;Airway Disease;Antibiotics;Award;biobank;Biological;Biological Markers;Birth;Blood;career;central database;Characteristics;Chemicals;Child;Child Development;Child Health;Childhood;Code;cohort;Cohort Analysis;Cohort Studies;Collaborations;community-level factor;Conceptions;Congresses;Consent;COVID-19;Data;Data Collection;Data Element;design;Diet;dietary;Dietary Factors;diversity and inclusion;DNA;Early identification;early life exposure;Early-life trauma;Employment;Enrollment;Ensure;Environmental Exposure;Environmental Risk Factor;epidemiology study;Evaluation;Event;experience;Family;Feces;Feedback;Fibrinogen;follow-up;Food;Food Supply;Fossil Fuels;Fostering;Generations;Genetic;genome wide association study;Geographic Locations;Geography;Goals;Growth;gut microbiome;Hair;Hand;Health;health determinants;health disparity;health equity;Health Food;health inequalities;Health Personnel;Healthcare;Human Milk;Income;Individual;Infrastructure;Institutional Review Boards;Instruction;Knowledge;Laboratories;Lead;Leadership;Life;Light;Livestock;Manuscripts;marginalized community;Marketing;Measures;Meconium;Mediating;Medical;metabolomics;microbiome;Mission;Modification;Molecular Epidemiology;neighborhood safety;neurodevelopment;New Hampshire;Noise;novel;Nutrient;Obesity;obesity genetics;obesity risk;offspring;Outcome;Participant;Pediatric cohort;perceived stress;Perinatal;Persons;pet animal;Phase;Physical activity;Placenta;Policies;Pollution;Poly-fluoroalkyl substances;Population;Population Heterogeneity;Pregnancy;pregnant;programs;prospective;Prospective Studies;Protocols documentation;Psychosocial Factor;Public Health;public health priorities;recruit;Research Personnel;Respiratory Tract Infections;Rice;Role;Rural;Rural Health;rural setting;rurality;sample collection;Sampling;Schools;Science;Site;social;social factors;Social isolation;Solid;Source;Structure of nail of toe;success;Talents;Temperature;Time;Tooth structure;toxicant;Trace Elements;Travel;United States National Institutes of Health;Urine;vaccine response;virtual;Vulnerable Populations;Water;Weather;well water;Wood stove;Work;working group

PROJECT_TITLE: A prospective study of critical environmental exposures in formative early life that impact lifelong health in rural US children: the New Hampshire Birth Cohort Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-S(50)R]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Substance Misuse;Women's Health Research

PI_NAMEs: DEBBINK, MICHELLE PRECOURT (contact)

PROJECT_TERMS: addiction;Address;Adult;Alaska Native;Alaska Native population;American Indian community;American Indian Population;Area;care coordination;Caring;Cessation of life;Cities;Clinic;Clinical;clinical center;Clinical effectiveness;clinical implementation;Clinical Services;cohort;Communities;community based participatory research;community engagement;Contracts;Counseling;County;Data;Dependence;design;Diné Nation;disorder risk;Education;effectiveness/implementation study;Enrollment;evidence base;Evidence based practice;Face;Feedback;follow-up;Foundations;Goals;Health Personnel;high risk;human centered design;hybrid type 1 design;Hybrids;implementation evaluation;implementation process;implementation science;improved;Infant;informant;innovation;Intervention;Interview;Knowledge;Length of Stay;lens;Manuals;maternal morbidity;Maternal Mortality;maternal outcome;Measures;Medical Records;medication for opioid use disorder;Mental Health;Mental Health Services;Modeling;Morbidity - disease rate;mortality;Mothers;multidisciplinary;Native American community;Navajo;Neonatal;neonatal outcome;Not Hispanic or Latino;novel;Outcome;Participant;patient oriented;Patient-Focused Outcomes;peer support;Perception;Perinatal;Perinatal Care;Persons;Phase;phase 2 testing;Population;postpartum care;Postpartum Period;Pregnancy;Pregnancy Outcome;pregnant;Prenatal care;preventable death;Process Assessment;Production;prospective;Protocols documentation;Randomized;Recovery;Research;Reservations;resilience;Review Committee;Risk;Risk Reduction;Rural;Services;simulation;social stigma;Social support;Sodium Chloride;substance use;Substance Use Disorder;substance use prevention;Testing;Toxicology;Training;Trauma;tribal community;Tribes;Universities;Urine;Utah;virtual experiments;Work

PROJECT_TITLE: CEREMONY: Culturally Engaged REcovery - MOms connected through Native community


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Genetics;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: ATHENS

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: Project Narrative The emergence of artemisinin-resistant Plasmodium falciparum threatens the recent gains in malaria control. In this project we will test the hypothesis that resistance develops in a two-step process comprised of an enhanced dormancy phenotype followed by acquisition of resistance conferring mutations. The results are expected to reveal a new mechanism of artemisinin-resistance.

PI_NAMEs: KYLE, DENNIS E (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Anti-malarials;Artemisinins;artesunate;Bacteria;Biological Assay;burden of illness;Candidate Disease Gene;Cells;Chromosome 10;Chromosome 13;Circulation;Clinical;clinically relevant;Combined Modality Therapy;Complex;Copy Number Polymorphism;CRISPR/Cas technology;Culicidae;Data;Development;drug discovery;Drug Exposure;Drug resistance;effective therapy;enhancer-binding protein AP-2;Erythrocytes;Exhibits;Exposure to;Gene Amplification;Genes;Growth;Half-Life;Image;imaging modality;In Vitro;Infection;Investigation;Laboratories;Link;Malaria;Malignant Neoplasms;Methods;Molecular;Multi-Drug Resistance;Mutation;novel;overexpression;Parasites;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Physiologic pulse;Plasmids;Plasmodium falciparum;Predisposition;pressure;prevent;Probability;Process;Publishing;Recovery;Refractory;Resistance;Resistance development;resistance mechanism;resistant Plasmodium falciparum;resistant strain;response;Role;Survival Rate;Testing;transmission process;treatment duration;Treatment Failure;Tuberculosis;Work

PROJECT_TITLE: Elucidating mechanisms for artemisinin-induced dormancy in Plasmodium falciparum

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIRT-J(01)]


PROJECT_TERMS: Academia;Acceleration;Awareness;Biotechnology;care delivery;Caregivers;Caring;Clinic;Clinical;Clinical and Translational Science Awards;commercialization;Communities;Community Developments;Detection;Development;Device or Instrument Development;Diagnosis;Discipline;Disparate;Education;Educational Curriculum;Educational process of instructing;Elements;Engineering;Event;evidence base;Exposure to;Feedback;Goals;Health;Healthcare;Heart Diseases;Hematological Disease;Home;Human Biology;improved;Industry;innovation;Innovation Corps;insight;interest;International;Knowledge;Lead;Learning;Lung Diseases;Massachusetts;Medical;Medical center;Medical Device;Medical Students;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;Needs Assessment;novel;Outcome;Patients;Persons;point of care;Point of Care Technology;Prevention;Process;product development;Professional Organizations;programs;prototype;Publications;remote monitoring;Reporting;Research;research clinical testing;Self Care;Series;Sleep Disorders;software development;Speed;Students;success;Symptoms;Technology;Technology Assessment;technology development;Training;training opportunity;Training Programs;Translation Process;undergraduate student;Validation;web site;webinar;Work

PROJECT_TITLE: Dissemination Core


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Physical Injury - Accidents and Adverse Effects;Pregnancy;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Women's Health Research

PI_NAMEs: COOPER, HANNAH LF (contact);LIVINGSTON, MELVIN D;RICE, WHITNEY SMITH

PROJECT_TERMS: Accountability;administrative database;American College of Obstetricians and Gynecologists;analytical method;Area;behavioral health;Birth;Black Populations;Black race;black women;Caring;Case Study;Child Abuse and Neglect;child protective service;Communities;community organizations;coral;Country;Death Rate;design;Discrimination;drug classification;Drug usage;drug use in pregnancy;Epidemic;Epidemiology;evidence base;experience;fighting;Harm Reduction;Health Personnel;health service use;Healthcare;Income;Inequity;interest;Intervention;Justice;Laws;Legal;Location;Maternal Health;Maternal Mortality;Medicaid;Medicine;Methods;Modeling;neglect;Outcome;Overdose;overdose risk;Pathway interactions;Persons;Pharmaceutical Preparations;Postnatal Care;Postpartum Period;Postpartum Women;Poverty;pregnant;Pregnant Women;prenatal;Public Health;reduced substance use;Reporting;reproductive;Research;Shapes;Social Workers;spatiotemporal;Substance Use Disorder;Theoretical model;Time;treatment program;United States Substance Abuse and Mental Health Services Administration;Variant;White Women;Woman;Women's Health

PROJECT_TITLE: OVAL: Overdoses Among Black pregnant/Postpartum People and Laws Governing Drug Use in Pregnancy: A Mixed-Methods Project to Support Mobilization


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases

ORG_DEPT: CHEMISTRY

PHR: Coronaviruses can cause severe respiratory infections in humans. We will investigate the molecular mechanisms by which coronaviruses remodel host cell membranes, which is an essential part of their replication. This work will help determine if membrane remodeling by coronaviruses may be a useful target for the development of future antiviral drugs.

PI_NAMEs: RAGUSA, MICHAEL JOSEPH (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;Amino Acids;Anti-viral Agents;Appearance;Binding;Biochemical;Biological Assay;Cell membrane;Cells;Cessation of life;Complex;Confocal Microscopy;Coronavirus;Coronavirus Infections;Cryo-electron tomography;Cryoelectron Microscopy;Death Rate;Detergents;Development;Drug Targeting;Endoplasmic Reticulum;experimental study;fighting;Fluorescence Spectroscopy;Freezing;Future;Genetic Transcription;Healthcare Systems;Human;human pathogen;In Vitro;Infection;insight;Integral Membrane Protein;Investigation;Length;Liposomes;Membrane;membrane model;membrane reconstitution;Membrane Structure and Function;Middle East Respiratory Syndrome Coronavirus;Molecular;mortality;Nonstructural Protein;novel;novel coronavirus;pandemic disease;particle;Population;Positioning Attribute;Process;Production;protein purification;Protein Region;protein structure;Proteins;reconstitution;Resolution;Respiratory Tract Infections;RNA Transport;RNA Viruses;Role;SARS coronavirus;screening;Shapes;Site;Social Distance;Structure;success;Surface;Testing;tool;Transmembrane Domain;transmission process;unilamellar vesicle;Vaccines;Vesicle;Viral Nonstructural Proteins;viral RNA;Virus;Virus Replication;Work

PROJECT_TITLE: Investigating the molecular mechanisms of membrane remodeling by coronaviruses

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Social Determinants of Health;Substance Misuse;Women's Health Research

PI_NAMEs: COHEN, SUSANNA ROSE (contact)

PROJECT_TERMS: Accident and Emergency department;adaptive intervention;adaptive learning;Address;adverse outcome;Artificial Intelligence;Birth;burnout;care delivery;Caring;Clinical;Clinical Skills;Collaborations;Communication;Communities;dashboard;Data;design;Disparity;Dissemination and Implementation;Educational Curriculum;Empathy;Enrollment;Environment;evidence base;Evidence based intervention;Face;Feedback;Focus Groups;Goals;Health;Health Professional;Healthcare;high risk;Hospitals;human centered design;implementation evaluation;implementation framework;improved;Individual;informant;innovation;Inpatients;Institution;Intervention;Interview;intrapartum;Justice;Language;Learning;learning strategy;Linear Regressions;marginalized population;maternal morbidity;Maternal Mortality;maternal risk;Measures;Medical;Medical Care Team;Medical Records;medical specialties;member;Modality;Modeling;Motivation;Newborn Infant;obstetric care;Outcome;Participant;participant enrollment;patient oriented;Patient Self-Report;Patient-Focused Outcomes;Patients;perinatal morbidity;Perinatal mortality demographics;person centered;Persons;post intervention;Postpartum Period;Pregnancy;pregnant;primary outcome;programs;prototype;Provider;Qualitative Methods;Quasi-experiment;Reach, Effectiveness, Adoption, Implementation, and Maintenance;reduced substance use;Research Infrastructure;resilience;response;rurality;Safety;Sampling;scale up;severe maternal morbidity;simulation;skills;social stigma;Specific qualifier value;Stigmatization;Substance Use Disorder;success;Surveys;System;Technology;Testing;therapy design;Time;Training;treatment adherence;Trust;United States National Institutes of Health;Universities;uptake;Utah;ward;webinar;Woman

PROJECT_TITLE: Project INSPIRE – (Interprofessional Simulation Program for Clinical Resilience and Empathy) for healthcare teams caring for birthing individuals with substance use disorder in Utah


NIH_SPENDING_CATS: Cancer;Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: Project Narrative  Maintenance of a healthy and functional skin throughout the adulthood, and in the face of constant mutational and physical challenge, depends on a balanced regulation of dynamic tissue growth promoting and suppressing behaviors. This proposal aims to take advantage of a series of novel findings into how skin epithelium can tolerate oncogenic mutations and recent improvements in experimental methods to characterize how the interaction between mutated cells and their normal epithelial neighbors, and mutated cells and their stromal neighborhood, coordinates growth promoting and suppressing choices critical to skin health and homeostasis.

PI_NAMEs: BERONJA, SLOBODAN  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Adult;Automobile Driving;axon guidance;Behavior;Biological Assay;Biology;Blood Vessels;cell type;Cells;Communication;Cues;Data;Dermal;Development;DNA Damage;driver mutation;Engineering;Engraftment;Ensure;Environmental Hazards;Ephrins;epidermal stem cell;Epidermis;Epithelial Cells;Epithelium;Equilibrium;Exposure to;Failure;frontier;Future;gain of function;gene function;Gene Targeting;Genetic Epistasis;Goals;Growth;Health;Homeostasis;Human;Immunofluorescence Immunologic;improved;innovation;intercellular communication;intravital imaging;Life;Ligands;loss of function;Maintenance;Malignant Neoplasms;Mediating;Methods;Molecular;mouse model;Mus;Mutagens;Mutate;Mutation;Neighborhoods;Normal Cell;novel;Oncogenes;Oncogenic;Pathogenicity;Pathologic;Pathway interactions;Pattern;Phenotype;Physically Challenged;postmitotic;prevent;progenitor;Proliferating;Publishing;receptor;Regulation;Research;response;self-renewal;Series;Signal Pathway;Signal Transduction;Site;Skin;stem cell differentiation;stem cell division;stem cell fate;stem cell growth;stem cell population;stem cells;Stromal Cells;synergism;Technology;Testing;Therapeutic;therapy design;Tissues;tumorigenesis;two photon microscopy;Wild Type Mouse;Work

PROJECT_TITLE: Differentiation balances oncogene-driven proliferation to maintain epidermal homeostasis

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Diabetes;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: GAINESVILLE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative: Tissue renin-angiotensin system (RAS) dysfunction contributes to increased inflammation, oxidative stress, and tissue damage in diabetes and its associated complications including diabetic retinopathy, the most common diabetic complication and the leading cause of blindness in the working-age population. The exact mechanisms how tissue RAS contribute to pathogenesis of diabetic retinopathy are still not well-understood. This proposal aims to determine the mechanisms of a critical component of RAS, the prorenin receptor and its soluble form, in pathogenesis of diabetic retinopathy; better understanding of these mechanisms will be vital for developing more effective therapeutic strategies for prevention and treatment of diabetic retinopathy.

PI_NAMEs: LI, QIUHONG  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Adaptor Signaling Protein;Age;Angiotensin II;Animal Model;Animals;antagonist;Binding;Blindness;Blood Circulation;Cardiovascular Diseases;Catalytic Domain;Cell Physiology;Cells;Clinical;Complex;Complications of Diabetes Mellitus;Data;Development;Diabetes Mellitus;diabetic;diabetic patient;Diabetic Retinopathy;effective therapy;Enzymes;Event;Eye;Functional disorder;Generations;Goals;Human;in vitro Assay;Inactive Renin;Inflammation;Inflammatory;inhibitor;Kidney;Knowledge;Link;Liquid substance;MAP Kinase Gene;MAPK3 gene;Mediating;Metabolic syndrome;Mitogens;Molecular Conformation;neurovascular;Obesity;Organ;Oxidative Stress;Pathogenesis;Pathologic;Pathway interactions;Patients;Peptide Hydrolases;Peptides;pH Homeostasis;Plasma;Play;Population;Prevention strategy;Production;proliferative diabetic retinopathy;prorenin receptor;Protein Kinase;Publishing;Reactive Oxygen Species;receptor;receptor binding;receptor function;receptor-mediated signaling;Renin;Renin-Angiotensin System;Reporting;response;Retina;Rodent;Role;Signal Pathway;Signal Transduction;Testing;therapeutically effective;Tissues;type I and type II diabetes;vacuolar H+-ATPase;WNT Signaling Pathway

PROJECT_TITLE: Pro/renin receptor-mediated signaling in pathogenesis of diabetic retinopathy

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pregnancy;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: HERNANDEZ, NATALIE DOLORES (contact)

PROJECT_TERMS: Accountability;Achievement;Acute;Address;Affect;Agreement;Anxiety Disorders;Area;behavioral health;behavioral health intervention;Birth;Black race;black women;Cessation of life;Child Health;Childbirth;Clinical;Collaborations;Communication;Communities;community empowerment;community engagement;community led intervention;community organizations;community partners;community partnership;Complex;coral;Country;Death Rate;depressive symptoms;Development;Equity;ethnic minority;experience;Family;Family health status;Goals;health inequalities;Healthcare;improved;Inequity;Infant;Infrastructure;innovation;intergenerational;Intervention;Investigation;Investments;Justice;Knowledge;Laws;Learning;Life Cycle Stages;Lived experience;Low income;Maintenance;Maternal Health;maternal morbidity;Maternal Mortality;maternal risk;Medical;member;Mental Health;Methods;minority communities;minority investigator;Modeling;Mothers;novel;Outcome;Overdose;Pathway interactions;Perinatal;Persons;physical conditioning;Policies;Policy Maker;Population;Post-Traumatic Stress Disorders;Postpartum Depression;Postpartum Women;Pregnancy;Pregnancy Complications;pregnancy related death;Pregnant Women;prevent;Process;Public Health;racial disparity;racial minority;reproductive;Research;Research Personnel;Research Project Grants;response;Review Committee;Scientist;social;social determinants;Social Policies;structural determinants;substance misuse;Substance Use Disorder;Techniques;Training;Translations;Trust;Underrepresented Minority;Voice;Woman;Work

PROJECT_TITLE: The CORAL Community Core


NIH_SPENDING_CATS: American Indian or Alaska Native;Brain Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Racial and Ethnic Minority Health Research;Rural Health;Substance Misuse;Women's Health Research

ORG_NAME: UNIVERSITY OF UTAH

PI_NAMEs: TANANA, HEATHER  (contact)

PROJECT_TERMS: Acceleration;addiction;Advocate;authority;Awareness;Black race;Clinic;Clinical;Collaborations;Communities;community advisory board;community center;community collaboration;community engagement;Community Health;community partners;community partnership;Dependence;Development;Disparity;Ensure;Equity;experience;Foundations;Future;Goals;Health;Inequity;Infrastructure;innovation;Knowledge;Leadership;Lived experience;marginalization;marginalized population;maternal morbidity;Maternal Mortality;meetings;Mission;Mothers;Outcome;Paiute Tribe;Pathway interactions;Patient Recruitments;Persons;Positioning Attribute;Postpartum Period;Pregnancy;pregnant;Qualitative Research;Recovery;recruit;Research;Research Personnel;Research Priority;Reservations;resilience;Resources;rural area;Rural Hospitals;scaffold;simulation;Strategic Planning;Structure;substance use;Substance Use Disorder;Training;Tribes;Trust;United States Dept. of Health and Human Services;Universities;uptake;Utah;virtual;Voice;Work

PROJECT_TITLE: Community Partnership


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_NAME: MOREHOUSE SCHOOL OF MEDICINE

PI_NAMEs: RICE, WHITNEY SMITH;TYUS, DAWN  (contact)

PROJECT_TERMS: Accountability;African American;Award;behavioral health;Birth;Black race;black women;career development;Career Mobility;Collaborations;Communities;community building;community collaboration;community engaged research;community engagement;community organizations;community partners;community partnership;Competence;coral;design;Ethics;experience;Faculty;Fostering;Funding;Generations;Goals;Grant;health disparity;Individual;innovation;interest;Intervention;Justice;Knowledge;Learning;learning community;Link;Maternal Health;Maternal-Child Health Centers;member;Mental Health;Mentors;Modeling;Morehouse School of Medicine;next generation;Persons;Postpartum Women;Pregnant Women;Principal Investigator;Production;programs;Public Health Schools;reproductive;Research;research and development;Research Personnel;Resources;Role;Scholars Program;Scientist;Shapes;Training;Translations;Underrepresented Minority;Universities;visiting scholar

PROJECT_TITLE: The CORAL Training Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: NEUROLOGY

PHR: Project narrative We will compare the responses of two groups of neurons in the brain that are defined by molecules that support brain development. We will make this comparison in adult animals to determine how these neurons support cognitive behavior even once brain development is complete. Disruption of the molecules we propose to study is known to drive developmental abnormalities, so understanding how they support cognitive behaviors is critical.

PI_NAMEs: CHURCHLAND, ANNE KATHRYN (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Address;Affect;Anatomy;Animals;Anterolateral;Area;area striata;Auditory;Award;Behavior;Brain;Calcium;candidate identification;cell type;Cells;clinically relevant;Cognitive;Communication;Corpus striatum structure;Coupled;Coupling;Data;Decision Making;Development;Disease;Dorsal;Event;excitatory neuron;experimental study;extrastriate visual cortex;Goals;hippocampal pyramidal neuron;Image;Individual;inhibitory neuron;insight;Interneurons;Laboratories;Life;Linear Models;Link;Maps;mature animal;Measurement;Measures;Modeling;Molecular;Motor;Movement;neural;neural circuit;neuromechanism;Neurons;novel;optogenetics;Pathway interactions;Pattern;Performance;Pontine structure;Population;Positioning Attribute;Pyramidal Tracts;recruit;Reporting;response;Retina;Role;Sensory;Shapes;Short-Term Memory;Signal Transduction;Specific qualifier value;Specificity;Spinal Cord;Stimulus;Stress Tests;Structure;superior colliculus Corpora quadrigemina;Testing;Thalamic structure;Theoretical model;Time;Training;transcription factor;two-photon;Update;Visual;visual stimulus;Work

PROJECT_TITLE: A cell-type specific explanation of visual decision circuits.

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Racial and Ethnic Minority Health Research;Rural Health;Substance Misuse;Women's Health Research

PI_NAMEs: TUROK, DAVID  (contact)

PROJECT_TERMS: addiction;Advocacy;Advocate;Affect;Alaska Native;American Indians;Attention;Awareness;biobehavior;Career Choice;Cessation of life;Clinic;Clinical;clinical care;clinical center;Clinical Research;Clinical Sciences;Collaborations;Communication;Communities;community engagement;community partnership;Dependence;Development;Discipline;Discipline of obstetrics;Discrimination;Disparity;dissemination science;doctoral student;Educational Curriculum;Empathy;Enrollment;Equity;experience;Faculty;faculty mentor;faculty research;Family;Foundations;Future;future implementation;Goals;Gynecology;Health Sciences;implementation science;implementation study;indigenous community;Individual;informant;Infrastructure;Institution;interdisciplinary collaboration;Intervention;Interview;Investigation;investigator training;Knowledge;Link;maternal morbidity;Maternal Mortality;Medical Examiners;Medicine;Mentors;Mission;Modeling;Morbidity - disease rate;mortality;Mothers;Perinatal;perinatal medicine;Persons;Politics;Positioning Attribute;Postdoctoral Fellow;Postpartum Period;Pregnancy;pregnancy related death;pregnant;programs;Public Health;Recovery;reduced substance use;Research;Research Personnel;Research Project Grants;Research Training;Resources;response;Review Committee;Role;Rural Community;Rural Population;Scholars Program;Scientist;skills;social;social stigma;Students;substance use;Substance Use Disorder;System;Training;training opportunity;Training Programs;Translational Research;Universities;Utah

PROJECT_TITLE: ELEVATE Training Integration Core


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Data Science;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases

ORG_CITY: ACCRA

ORG_COUNTRY: GHANA

ORG_FIPS: GH

ORG_NAME: COLLEGE OF HEALTH SCIENCES, UNIVERSITY OF GHANA

PHR: PROJECT NARRATIVE The aim of the proposed training program is to enhance research into zoonoses and food-borne infections in West Africa through the application of data science. The training program provides one-year research training to MSc students and faculty members in West Africa, as well as organizing training workshops to wider communities in the sub-region.

PI_NAMEs: SAMPANE-DONKOR, ERIC  (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Address;Africa;African;authority;Bioinformatics;career;Communicable Diseases;Communities;Data Science;Data Scientist;Disease;disease model;Educational workshop;Faculty;faculty support;Food;foodborne infection;Goals;Government;graduate student;Health;health data;Institution;interest;member;Mentorship;Pharmaceutical Preparations;Procedures;programs;Public Health;recruit;Research;Research Project Grants;Research Training;Scientist;skills;Students;tool;Topical application;Training;training data;Training Programs;Training Support;Universities;Work;Zoonoses

PROJECT_TITLE: Application of Data Science to Build Research Capacity in Zoonoses and Food-Borne Infections in West Africa

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BTC-L(70)R]


NIH_SPENDING_CATS: Contraception/Reproduction;Infectious Diseases;Maternal Health;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Leveraging recent and novel findings from our human studies and mouse models, we propose an innovative approach to study sPTB. With a multidisciplinary team of scientists, we will utilize both in vitro and in vivo models to comprehensively analyze how cervicovaginal bacteria induce EMT and cervical remodeling. These studies will reveal key steps in the pathogenesis of sPTB. Findings from this proposal will provide insight as to new therapeutic targets to limit or prevent sPTB and in this manner, will fundamentally advance this field.

PI_NAMEs: ELOVITZ, MICHAL AVIVA (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Address;Automobile Driving;Bacteria;Biological Process;Biomechanics;Birth;Cancer Biology;Cervical;cervical remodeling;cervicovaginal;Cervix Uteri;clinically relevant;cohort;commensal bacteria;Epithelial Cells;Epithelium;Etiology;experimental study;Extracellular Matrix;fetal;Fetal Membranes;Fibrosis;Fostering;Gardnerella vaginalis;Gelatinase B;Germ-Free;Goals;Human;Immune response;In Vitro;in vivo;in vivo Model;Infection;Inflammation;Inflammation Mediators;innovation;insight;intraamniotic infection;Knowledge;Measures;Mesenchymal;Metabolic;metabolic profile;microbial community;microbiota;mouse model;Mucous Membrane;multidisciplinary;Mus;new therapeutic target;novel;Pathogenesis;Peptide Hydrolases;Placenta;Pregnancy;pregnant;Pregnant Women;premature;Premature Birth;prevent;Preventive;Process;Production;Proteomics;reproductive tract;response;Scientist;Series;Structure;Study models;successful intervention;Techniques;Term Birth;Testing;Therapeutic;therapeutic target;Time;Tissues;uterine contractility;Uterus;Vagina;vaginal infection;Work

PROJECT_TITLE: Unraveling mechanisms by which cervicovaginal microbiota can promote or prevent cervical remodeling and preterm birth


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE A new biotechnology for type 1 diabetes will be developed that utilizes innovative biodegradable nanoparticles for delivery of biological cargos to target immune cells. The nanoparticles will be designed to program a specific tolerogenic immune response to prevent and treat type 1 diabetes.

PI_NAMEs: DOLOFF, JOSHUA CHARLES;GREEN, JORDAN  (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Affect;Antigen Presentation;Antigen-Presenting Cells;antigen-specific T cells;Antigens;Autoantigens;Autoimmune;Autoimmune Diseases;Biocompatible Materials;Biodistribution;Biological;biophysical properties;Biotechnology;Cell secretion;cell type;Cells;cellular engineering;chemical property;Coculture Techniques;cytokine;cytotoxicity;Dendritic Cells;design;Development;Diabetes prevention;diabetic;Disease;Disease Progression;Drug Kinetics;Engineering;Ensure;Environment;Esters;Gene Delivery;Gene Expression;Genes;Genetic Engineering;Human;humanized mouse;Immune;immune activation;Immune response;Immune system;Immune Targeting;immunoengineering;immunoregulation;Immunosuppression;In Vitro;in vitro Model;in vivo;Inbred NOD Mice;Injections;innovation;Insulin;Insulin-Dependent Diabetes Mellitus;Islet Cell;Islets of Langerhans;Kinetics;Life;Liver;Macrophage;Maintenance;Mediating;Messenger RNA;Methods;Modeling;monocyte;mouse model;mRNA delivery;Mus;nanobiotechnology;nanoparticle;nanoparticle delivery;Non obese;Nucleic Acids;Oligonucleotides;Organ;Pancreas;particle;Patients;Phenotype;prevent;Prevention;programs;Property;recruit;Regulatory T-Lymphocyte;Reporter;Reporter Genes;Safety;Severity of illness;Signal Transduction;Sirolimus;small molecule;Specificity;Spleen;System;T cell receptor repertoire sequencing;T-Lymphocyte;Technology;Therapeutic Uses;Transfection;Transgenic Mice;Translations;United States;Vaccines

PROJECT_TITLE: Tolerance-Inducing mRNA Nanoparticles to Treat Type 1 Diabetes


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics

ORG_DEPT: DERMATOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE  Aging causes disorganization of three-dimensional chromatin architecture. This project aims to determine the mechanism by which changes in chromatin architecture during aging contribute to age-associated deterioration, which will expedite the development of new and effective therapeutics against age-related diseases.

PI_NAMEs: BECK, SAMUEL  (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: 3-Dimensional;Address;age acceleration;Age of Onset;age related;age related deterioration;Age related pathologies;age-related disease;aged;Aging;aging related disease;Architecture;Automobile Driving;Bromodomain;Bromodomains and extra-terminal domain inhibitor;Caenorhabditis elegans;Cardiomyopathies;Cell Aging;Cell Nucleus;Cells;Chromatin;Chronic;Computer Analysis;CpG Islands;cytokine;Data;Deterioration;Development;drug repurposing;Echocardiography;Elements;Exhibits;frailty;Functional disorder;Gene Expression;Genes;Genetic Transcription;hallmarks of aging;Heart;Heterochromatin;Histology;Homeostasis;Human;Immune;Immunofluorescence Immunologic;in silico;indexing;Inflammation;Inflammatory;innovation;ischemic cardiomyopathy;life span;Mediating;mouse model;mRNA sequencing;Mus;Noise;normal aging;novel;Nuclear;Nuclear Lamina;Oncogene Deregulation;Organ;Pattern;pharmacologic;Physiological;Plasma;Premature aging syndrome;promoter;Protein Family;Proteome;Pulmonary Fibrosis;Reporting;Research;RNA;single-cell RNA sequencing;Stroke;System;systemic inflammatory response;Testing;therapeutically effective;Time;Tissues

PROJECT_TITLE: Loss of transcriptional homeostasis of genes lacking CpG islands during aging

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: The future of biomedical and molecular biological research in the U.S. is dependent on the training of high quality, passionate PhD scientists who have learned to think critically and independently. The Molecular Biology Program at the University of Colorado Anschutz Medical Campus fosters the development of critically minded, dedicated researchers who can communicate effectively, investigate across disciplinary boundaries, and understand the human health implications of their studies.

PI_NAMEs: HESSELBERTH, JAY R;PREKERIS, RYTIS  (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Molecular and Cellular Biology;pre-doctoral;Training Programs

PROJECT_TITLE: Predoctoral Training Program in Molecular and Cellular Biology

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it employs novel approaches to investigate mechanisms of the developmental effects of ethanol as seen in Fetal Alcohol Spectrum Disorders (FASD), a leading cause of intellectual and behavioral disabilities and mental health disorders. The proposed studies will provide insights on how alterations in astrocytes (brain cells essential for the proper development and function of the brain) will result in altered adult brain functions leading to altered behavior. The proposed research is relevant to the NIAAA's mission because the aforementioned insights, obtained using emerging clinical animal models and “-omic” approaches in a cell-type specific manner (astrocytes), will provide new mechanistic and understanding on the impact of fetal alcohol on disease outcomes in adulthood andwill lead to therapeutic interventions that are not only specific for a given molecular target, but also for a given cellular target and, for this reason, safer.

PI_NAMEs: GUIZZETTI, MARINA  (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Address;Adult;Affect;Affinity Chromatography;alcohol effect;alcohol exposure;Alcohols;Animal Model;Astrocytes;Behavior;Behavioral;Biological Process;Brain;brain cell;Brain region;Cell Nucleus;Cell Separation;cell type;Cells;cellular targeting;Clinical;Data;Development;disability;Disease;Disease Outcome;Ethanol;Extracellular Matrix;Extracellular Matrix Proteins;Female;fetal;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fluorescence;Fluorescent in Situ Hybridization;Functional disorder;Gene Expression;Genes;Genetic Transcription;Health;Heterogeneity;Hippocampus;Immunohistochemistry;in vivo;Inflammatory Response;insight;interest;Knowledge;Lead;male;Mediating;Mental disorders;Messenger RNA;Methods;Mission;Molecular;Molecular Target;mouse model;Mus;National Institute on Alcohol Abuse and Alcoholism;Neonatal Alcohol Exposure;neuron development;new technology;NIH Program Announcements;novel strategies;Nuclear;Nuclear RNA;Pathway Analysis;Play;posttranscriptional;Prefrontal Cortex;Process;promoter;Proteins;Public Health;Publishing;Reporting;Research;response;Ribosomal Proteins;Ribosomes;RNA;Role;sex;Sorting;Specificity;Synapses;synaptogenesis;System;Therapeutic Intervention;transcriptome;transcriptome sequencing;Translating;Translations;translatome;United States National Institutes of Health;Western Blotting

PROJECT_TITLE: Astrocyte gene expression and translation in an in vivo FASD mouse model

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dementia;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Neurodegenerative;Patient Safety;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW ORLEANS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PUBLIC HEALTH RELEVANCE: In the proposed study, we will test a multifaceted strategy for implementing an intensive blood pressure intervention protocol targeting systolic BP <120 mmHg on cognitive decline in racial minority and low-income hypertensive patients in primary care. The proposed study will generate urgently needed data on effective, adoptable, and equitable intervention strategies to reduce blood pressure-related cognitive decline in low- income and minority populations. If proven effective, the implementation strategy for intensive blood pressure reduction could be adapted and scaled up in diverse primary care settings to prevent cognitive decline and clinical dementia.

PI_NAMEs: HE, JIANG ;MILLS, KATHERINE TERESA (contact);WILLIAMSON, JEFF DOUGLAS

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: adjudication;Adopted;Adoption;Adult;Adverse effects;African American;Age Years;aged;Algorithms;Blood Pressure;blood pressure control;blood pressure intervention;blood pressure reduction;Clinic;Clinical;Clinical Trials;Clinical Trials Data Monitoring Committees;Cluster randomized trial;Cognitive;cognitive function;cognitive testing;collaborative care;Communication;Consent Forms;cost;cost effectiveness;Data;Data Collection;Dementia;dementia burden;Development;Diastolic blood pressure;Effectiveness;effectiveness evaluation;effectiveness outcome;effectiveness testing;effectiveness/implementation design;Electronic Health Record;Ensure;Equity;Evaluation;executive function;Federally Qualified Health Center;Feedback;follow-up;Global Change;Health;Home Blood Pressure Monitoring;human old age (65+);Hypertension;hypertension control;hypertensive;Impaired cognition;implementation evaluation;implementation outcomes;implementation strategy;implementation trial;improved;Institutional Review Boards;Intensive Care;Intervention;intervention delivery;Intervention Trial;Interview;Journals;Louisiana;Low income;Low Income Population;Memory;Meta-Analysis;mild cognitive impairment;Minority;Minority Groups;Mississippi;multi-component intervention;Outcome;Outcome Measure;Outcome Study;Participant;participant enrollment;patient oriented;Patients;Penetrance;Phase;prevent;Primary Care;primary care practice;primary care setting;primary outcome;Protocols documentation;Public Health;public health relevance;Published Comment;Quality of life;racial minority;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Research Design;Resources;retention rate;Review Committee;Risk;Rural Population;Sample Size;Sampling;scale up;secondary outcome;shared decision making;Side;staff intervention;Surveys;Testing;Training;treatment as usual;treatment strategy

PROJECT_TITLE: Effectiveness of Implementing an Intensive Blood Pressure Reduction Intervention on Cognitive Decline in Low-income and Minority Hypertensive Patients