ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Narrative Diversity supplement funding is requested to support the research and career training of Ms. Anna Kelly, who is a graduate of the Bioengineering Department at the University of Pittsburgh and whose career goal is to become a physician-scientist to provide accessible care to her patients and to contribute to the science that impacts them. Ms. Kelly will receive research and career training under the parent grant investigating the charge transfer, electrochemical, and biocompatibility properties of electrodes on the efficacy and safety of microstimulation, with her independent research project under the parent grant focusing on the effects of microstimulation on the integrity of the blood-brain barrier and brain vasculature. This research and career training will be invaluable for Ms. Kelly in achieving her future goal of becoming a physician-scientist in neural engineering and will contribute significantly to her future success in the field.

PI_NAMEs: CUI, XINYAN TRACY (contact)

PROGRAM_OFFICER_NAME: HWANG, GRACE MEI-HUA

PROJECT_TERMS: Acute;Address;Animals;Auditory;Autopsy;Behavior;bioelectronics;Biological;biomaterial compatibility;Biomedical Engineering;Blood - brain barrier anatomy;Blood Vessels;Brain;BRAIN initiative;brain tissue;calcium indicator;career;Caring;Cells;Cerebrovascular system;Charge;Chronic;Cultured Cells;Devices;electric impedance;Electrodes;Engineering;experience;experimental study;Extravasation;Funding;Future;Gliosis;Goals;Health;Histology;Implant;implantation;improved;In Vitro;in vivo;Inflammatory;interest;Label;Laboratories;Leukocytes;Link;Medicine;Microelectrodes;Microglia;microstimulation;Mus;neural;neural implant;neural stimulation;Neuroglia;neuron loss;Neurons;parent grant;parent project;Parents;Patients;Performance;Peripheral;Physicians;Physiological;Plasma;Predisposition;programs;Property;Proteins;Publications;Research;Research Personnel;Research Project Grants;Research Support;response;restoration;Safety;Science;Scientist;Secure;somatosensory;Structure;success;Technology;Tissue Engineering;Tissues;Training;Transgenic Mice;two photon microscopy;Universities;Visual;Work

PROJECT_TITLE: Efficiency and Safety of Microstimulation Via Different Electrode Materials


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Nutrition;Sleep Research

ORG_CITY: LA JOLLA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative  Alzheimer’s disease (AD) affects more than 5 million Americans over the age of 60 and manifests with progressive memory loss, decline in cognitive abilities, and altered circadian regulation, which affects sleep- wake patterns and behavior and represents the main factor of hospitalization and morbidity. The daily feed/fast cycle is a powerful regulator of the circadian system, and we recently demonstrated that time-restricted feeding improves key disease components including memory, sleep, disease pathology, and brain transcription in mouse models of AD. We will investigate the safety, feasibility, and effectiveness of prolonged night fasting in reducing cognitive decline and disease markers in patients with cognitive impairment due to AD.

PI_NAMEs: DESPLATS, PAULA ALEJANDRA (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, BENFEARD LEECHELLE

PROJECT_TERMS: Address;Adherence;Adult;Affect;Age;Aging;aging biomarker;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;American;Amyloid;Amyloid beta-42;Amyloid deposition;Animal Model;Attention;Attenuated;Behavior;Behavioral;Biological Clocks;Blood;blood-based biomarker;Brain;Caloric Restriction;Cardiometabolic Disease;circadian;Circadian Dysregulation;circadian pacemaker;circadian regulation;Circadian Rhythms;Clinical;clinical diagnosis;clinical efficacy;Clinical Management;Clinical Trials;Cognition;Cognition Disorders;Cognitive;cognitive ability;cognitive function;Collection;cost;Data;Death Rate;Dementia;design;Diagnosis;Dietary Intervention;Disease;Disease Marker;Disease Progression;drug development;Eating;Effectiveness;effectiveness testing;Elderly;Enrollment;Environment;epigenetic aging;epigenetic profiling;Episodic memory;Evaluation;executive function;experience;Family;Fasting;feasibility testing;feeding;food restriction;Formulation;Genes;Genetic Transcription;Glucose;Glycosylated hemoglobin A;Goals;group intervention;Health;Hospitalization;Hour;Human;Human body;human old age (65+);Hyperactivity;Impaired cognition;improved;improvement on sleep;Individual;Inflammation;Insulin;Intervention;Investigation;Ketones;Lipids;Longevity;Memory;Memory impairment;Memory Loss;Metabolic;Metabolism;Methods;mild cognitive impairment;Modeling;Monitor;Morbidity - disease rate;mouse model;Mus;Nature;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;neuropathology;Nursing Homes;Nutrient;older adult;Outcome;Outcome Assessment;Oxidative Stress;Participant;Pathologic;Pathology;Patients;Pattern;Persons;Pharmaceutical Preparations;Phase;Physiology;Pilot Projects;pilot trial;Plasma;Polysomnography;Population;preclinical study;primary outcome;Protocols documentation;Randomized;recruit;Regimen;Research;Role;Safety;safety and feasibility;safety testing;Senile Plaques;Sleep;Sleep disturbances;Special Equipment;Stimulus;System;Therapeutic;Time;time use;Time-restricted feeding;Visit;Work

PROJECT_TITLE: Time Restricted Eating intervention for Alzheimer's disease (TREAD)

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: NEW ORLEANS

ORG_DEPT: PEDIATRICS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative The University of Sierra Leone, College of Medicine and Allied Health Sciences (COMAHS) and Kenema Government Hospital (KGH), in partnership with Tulane University; will build upon successes of its first five-year period to continue developing implementation science and clinical trial research capacity for emerging infections in Sierra Leone. The overarching five-year goal of the PREVSL project, in Phase II, will be to provide the support necessary to COMAHS and its newly launched PhD degree program in Biomedical Sciences and Public Health that will anchor effective systems over time and ensure the PhD programs long-term sustainability. We will do this while continuing to strengthen the KGH clinical research program as a training site for future student and researchers through the promotion of ongoing implementation science and clinical trial research in emerging infections from which trainees can attain practical and applied research skills.

PI_NAMEs: GRANT, DONALD SAMUEL;SAMAI, MOHAMED ;SCHIEFFELIN, JOHN SCRIBNER (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: 2019-nCoV;Africa;Agriculture;Allied Health Sciences;Animals;Antimicrobial Resistance;Applied Research;Automobile Driving;Award;Capital;chikungunya;Chiroptera;Cities;Clinical Research;Clinical Trials;college;Communicable Diseases;Country;Crimean Hemorrhagic Fever;Dengue;detection limit;Discipline;Disease Outbreaks;Doctor of Philosophy;doctoral student;Emerging Communicable Diseases;Emerging infection;Ensure;experience;Foundations;Future;Geography;Government;Health;health science research;Healthcare;Hospitals;implementation science;Incidence;Infectious Diseases Research;Influenza;Infrastructure;Institution;institutional capacity;International;Lassa Fever;Marburgvirus;Master of Science;medical schools;Medicine;Monkeypox;next generation;pandemic preparedness;Persons;Phase;Population;programs;Province;Public Health;Research;Research Personnel;Scientist;Sierra Leone;Site;skills;System;Training;Universities;Viral Hemorrhagic Fevers;Virus Diseases;Yellow Fever;Zoonoses

PROJECT_TITLE: Partnership for Research in Emerging Viral Infections-Sierra Leone (PREVSL)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-D (55)]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Regenerative Medicine;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE As the U.S HIV population ages the proportion of those diagnosed with cancer (such as HIV-related lymphomas) will continue to rise, emphasizing an urgent need for equitable access to curative lymphoma treatments such as hematopoietic cell transplants (HCT). This project will characterize the inequitable utilization of HCTs based on social determinants of health among California patients with HIV-related lymphomas, and elucidate differences in care outcomes based on HIV status and transplant type. Through the use of an innovative linked cancer registry dataset, the findings from this project will expand the knowledge base on inequitable HCT utilization and the related social determinants of health to support interventions that will close the gap in health disparities within this vulnerable population.

PI_NAMEs: DAVID, KURT A (contact)

PROGRAM_OFFICER_NAME: WILLIS, LEIGH ANDREW

PROJECT_TERMS: Address;Adoption;Adult;Advanced Malignant Neoplasm;African American;Age;AIDS-Related Lymphoma;Anti-Retroviral Agents;Autologous;Biometry;Black race;Blood;Bone Marrow Transplantation;California;cancer epidemiology;Cancer Patient;cancer therapy;care outcomes;Caring;case control;chemotherapy;Chemotherapy and/or radiation;Clinical;clinical care;Clinical Management;cohort;Communicable Diseases;Communities;comorbidity;curative treatments;Data;Data Set;design;Development;Diagnosis;disparity gap;Drug Interactions;Eligibility Determination;Epidemiology;Equity;ethnic minority;experience;Face;Future;Goals;Grant;Guidelines;health care disparity;health disparity;health equity;Hematopoietic Stem Cell Transplantation;HIV;HIV diagnosis;Hospitalization;Hospitals;improved;Inequity;infection risk;innovation;insight;Insurance;international center;Intervention;Intervention Studies;Knowledge;knowledge base;Leadership;lens;Link;low socioeconomic status;Lymphoma;Malignant Neoplasms;Measures;Mentors;Modeling;National Institute of Nursing Research;Neighborhoods;neoplasm registry;Nurses;older adult;Opportunistic Infections;Outcome Study;Patient Discharge;Patients;Persons;Pharmaceutical Preparations;Population;population health;Principal Investigator;Privatization;Process;racial minority;Research;Risk;Sampling;San Francisco;Scientist;secondary analysis;skill acquisition;skills;social health determinants;social influence;sociodemographic factors;sociodemographics;Socioeconomic Status;Stage at Diagnosis;Statistical Methods;Supportive care;survival outcome;Survival Rate;System;Testing;Training;transplant centers;Transplant Recipients;Transplantation;Universities;Vulnerable Populations

PROJECT_TITLE: Examining Health Disparities in the use of Hematopoietic Cell Transplants for HIV-related Lymphoma

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: National Institute of Nursing Research Initial Review Group[NRRC (88)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Animal survival is dependent on locomotion to successfully find shelter, locate a mate, capture prey, and avoid predators. The goal of this proposal is to utilize the optically transparent and genetically tractable zebrafish model system to elucidate the mechanisms of glutamatergic signaling responsible for regulating the properties of in vivo spinal locomotor output, which will set the basis for a better understanding for the control of vertebrate locomotion. Since many principles of CPG function are conserved across vertebrates it is likely that these findings will translate to other animals, including humans.

PI_NAMEs: MASINO, MARK A (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: AMPA Receptors;Animals;antagonist;Behavior;Behavioral;Biological Models;Brain;Calcium;central pattern generator;Complement;Data;Electrophysiology (science);experimental study;Foundations;Frequencies;Future;Generations;Glutamate Receptor;glutamatergic signaling;Glutamates;Goals;Head;Human;Image;in vivo;innovation;Investigation;Knowledge;Larva;Locomotion;Mediating;Metabotropic Glutamate Receptors;model organism;Molecular;Motor Activity;Motor Neurons;Motor output;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;Nature;Neurons;neuroregulation;Optics;optogenetics;Output;Partner in relationship;Periodicity;Peripheral Nerves;pharmacologic;Pharmacology;Play;Preparation;Property;Proteins;Publishing;receptor;receptor function;Receptor Signaling;recruit;Reporter;Role;Shelter facility;Side;Speed;Spinal;Swimming;Tail;Time;tool;Translating;Vertebrates;Zebrafish

PROJECT_TITLE: Dissecting the roles of glutamatergic receptor subtypes in spinal locomotor circuit function

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homelessness;Mental Health;Mental Illness;Opioids;Pediatric;Prevention;Social Determinants of Health;Suicide;Violence Research;Youth Violence

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Projective Narrative Youth experiencing homelessness (YEH) face high rates of childhood adversity and trauma on the streets, which are associated with impaired mental health. The purpose of this study is to examine associations between adversity profiles, social network processes (support and behavior), psychological distress (depressive symptoms, suicidal ideation, and suicide attempt), and physiological stress (hair cortisol concentration) among YEH, and the potential for social networks processes to buffer the negative effects of adversity. The results of this study may contribute to targeted interventions for YEH after adversity and prevent subsequent negative health outcomes.

PI_NAMEs: FITZPATRICK, MARGARET M. (contact)

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: Address;Adolescence;Adolescent;Affect;Age;Behavior;Buffers;career;Caregivers;Child Abuse;Child Abuse and Neglect;Childhood;childhood adversity;Chronic;critical period;Data;Data Set;demographics;depressive symptoms;deviant peer;Discipline of Nursing;disparity reduction;emerging adulthood;emotional abuse;Environment;Evidence based intervention;experience;Exposure to;Face;Family;Feeling suicidal;Foundations;Friends;Funding;Future;Goals;Hair;Health;health equity;health inequalities;Health Priorities;Heterogeneity;Homeless Youth;Homelessness;Housing;Hydrocortisone;hypothalamic-pituitary-adrenal axis;Impairment;Institution;Intervention;Investigation;Knowledge;lens;Life Cycle Stages;marginalization;marginalized population;Measures;Mental Depression;Mental Health;Mental health promotion;mortality;Motivation;National Institute of Drug Abuse;National Institute of Nursing Research;neglect;Nursing Faculty;Opioid;opioid use disorder;Outcome;Pathway interactions;Pattern;pediatric trauma;peer;person centered;physical abuse;Physiological;Physiology;Population;pre-doctoral;prevent;Prevention;prevention service;Process;programs;protective factors;protective pathway;psychologic;psychological distress;Randomized, Controlled Trials;Regression Analysis;Reporting;Research;Research Personnel;Research Priority;residence;Risk;Role;satisfaction;Science;secondary analysis;Sexual abuse;skills;social health determinants;Social isolation;Social Network;Social support;Societies;Stress;Suicide;Suicide attempt;support network;System;Training;Trauma;United States;United States National Institutes of Health;Victimization;Violence;Work;young adult;Youth

PROJECT_TITLE: Associations Between Adversity and Psychological Distress and Physiological Stress Among Youth Experiencing Homelessness: The Buffering Role of Social Network Processes


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: BOSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: PROJECT NARRATIVE Although peripheral viremia is suppressed in people living with HIV (PLWH) since the advent of combination anti-retroviral therapy, a significant portion of PLWH still suffer from comorbidities and complications. This project aims to determine the molecular mechanism of chronic inflammation, the chief driver of non-AIDS complications, caused by persistent HIV infection in PLWH on suppressive therapy. Successful completion of this proposal would help develop new therapeutics towards a functional cure of HIV.

PI_NAMEs: AKIYAMA, HISASHI  (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, GERARD

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;Aging;antiretroviral therapy;base;Binding Sites;Bioinformatics;bioinformatics tool;Boston;Brain;Cells;Chronic;cohort;Collaborations;comorbidity;Complication;crosslink;Cytoplasm;Data;Deposition;effective therapy;epitranscriptomics;Genetic Transcription;HIV;HIV Infections;HIV-1;Human;Human immunodeficiency virus test;immune activation;Immunoprecipitation;Individual;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;Innate Immune Response;Introns;knock-down;Life Cycle Stages;Link;Macrophage;Mediating;Medical center;Microglia;Modification;Molecular;monocyte;mutant;nanopore;neurocognitive disorder;novel therapeutics;Nucleotides;Pathway interactions;Peripheral;Peripheral Blood Mononuclear Cell;Persons;Physicians;Plasma;Play;posttranscriptional;prevent;protein expression;Proteins;Proviruses;Pseudouridine;Reader;Reading;Regimen;Reporting;Research;Resolution;Risk Reduction;RNA;RNA Binding;RNA Stability;RNA-Protein Interaction;Role;Scientist;Site;Small Interfering RNA;systemic inflammatory response;Technology;Testing;Tissues;transcriptome sequencing;Viral Genes;viral RNA;Viremia;Work

PROJECT_TITLE: RNA modification and innate immune activation in HIV infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 JBS-A (J1)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Orphan Drug;Orthopoxviruses;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Vaccine Related

ORG_CITY: NEW YORK

ORG_DEPT: DERMATOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PUBLIC HEALTH RELEVANCE Infections and tumors evade early immune detection in barrier tissues such as the skin, lung, and gut. The application offers foundational insight into how tissue-specific immunity is generated, and maintained in our, for which there is a current urgent need, given the SARSCoV2 pandemic (lung) and Monkeypox (skin) outbreak. We predict mechanisms being investigated in this application are central to modeling better vaccine immunizations, to understanding the efficacy and toxicity from immune based drugs being used in patients, to generating better adoptive cell therapies, and to therapeutically limit autoimmunity.

PI_NAMEs: ANANDASABAPATHY, NIROSHANA  (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: 2019-nCoV;Adoptive Cell Transfers;Affinity;anti-PD1 therapy;antigen challenge;Antigens;Apoptosis;Autoimmune;autoimmune pathogenesis;Autoimmunity;autoinflammation;Biology;CD8B1 gene;Cell Cycle;Cell Death;Cell Therapy;Cells;Cellular Immunology;Chickenpox;Chronic;combat;COVID-19 pandemic;Data;Dendritic Cells;Detection;Development;Disease;Disease Outbreaks;effector T cell;Engraftment;Ensure;Epitopes;Equilibrium;Event;exhaustion;Future;Genetic;Goals;Health;Homeostasis;Immune;immune checkpoint;immune modulating agents;Immune Tolerance;immune-related adverse events;Immunity;Immunization;Immunologic Memory;Immunology;improved;in vivo;in vivo Model;Infection;Inflammation;Influenza;Injury;insight;Intervention;Knowledge;Length;Life Cycle Stages;life span;Ligands;Longevity;Lung;Maintenance;Malignant Neoplasms;Mediating;Melanoma;Memory;memory recall;Methods;Modeling;Molecular;Monkeypox;mouse model;Neoplasm Metastasis;novel;novel therapeutics;Organ;pathogen;Pathogenicity;Patients;Peptides;Peripheral;Pharmaceutical Preparations;pharmacologic;Phase;physiologic model;Population;Pre-Clinical Model;preservation;prevent;progenitor;programmed cell death ligand 1;programmed cell death protein 1;Proliferating;Proteins;Psoriasis;public health relevance;Receptor Activation;Receptor Signaling;recruit;Recurrence;Residencies;Role;SARS coronavirus;Sentinel;Shapes;Signal Transduction;Site;Skin;Skin Tissue;Smallpox;Smallpox Vaccine;sound;stemness;Surveys;Synapses;Systems Biology;T cell response;T cell therapy;T memory cell;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;telomere;Testing;Therapeutic;tissue injury;Tissue Model;tissue resident memory T cell;Tissues;tool;Toxic effect;Transgenic Mice;Tumor Escape;vaccination strategy;Vaccine Design;Vaccines;Vaccinia virus;Viral;Virus;Vitiligo;Work

PROJECT_TITLE: New mechanisms governing skin tissue residency memory T cells

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative: Skin immunity plays a pivotal role in mitigating tick feeding. In this R21 application, we will determine how the salivary protein sialostatin L2 affects alarmin immune signaling in keratinocytes during a tick bite. The epidermis, which interfaces with the external environment, has been neglected when studying ectoparasite feeding on a mammalian host. Collectively, this R21 project will advance fundamental knowledge of tick-borne diseases.

PI_NAMEs: PEDRA, JOAO  (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: acquired immunity;Affect;Anaplasma phagocytophilum;Anesthetics;Annexins;Anticoagulants;Applications Grants;Arthropods;Binding;Biological Process;Black-legged Tick;Blood;Borrelia burgdorferi;Castor Bean Tick;Cathepsins;Cattle;Cavia;Cell surface;Cells;Chromatin;Clinical;Coupled;Cysteine Proteinase Inhibitors;Data;Dendritic Cells;Dermis;Disease;Engineering;Environment;Epidermis;Event;extracellular;feeding;Fermentation;functional plasticity;Genetic Transcription;Growth;HMGB1 gene;Homeostasis;human disease;Immune;Immune response;Immune signaling;Immunity;Immunobiology;Immunologics;Immunology;immunoregulation;Immunosuppression;Impairment;Infection;Inflammasome;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;insight;Interferon Type I;Ixodes;keratinocyte;Knowledge;learning community;Link;Location;Mammals;Mediating;Microbe;Modeling;Molecular;Molecular Biology Techniques;Mus;neglect;novel;Nuclear;Orthologous Gene;Oryctolagus cuniculus;Pattern;Pattern recognition receptor;Play;pluripotency;Post-Translational Protein Processing;prevent;Property;Proteins;Resistance;response;Rickettsia;Role;Salivary;Salivary Glands;Salivary Proteins;scaffold;Severities;Signal Transduction;Skin;Structure;success;synthetic biology;Systems Biology;tick bite;tick feeding;tick saliva;Tick-Borne Diseases;Tick-Borne Encephalitis;Ticks;transcriptomics;transmission process;United States National Institutes of Health;Vaccines;Work

PROJECT_TITLE: Subversion of Keratinocyte Function by a Tick Salivary Protein

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-B (02)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: ATLANTA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Tuberculosis (TB) is the leading cause of death due to an infectious disease globally and remains a serious public health problem in Ethiopia which is on the WHO “high burden countries” lists for TB and TB/HIV. A shortage of well-trained TB investigators in Ethiopia and globally remains a major barrier to achieving the WHO End TB Strategy goals to eliminate TB by 2035. The goals of this D43 renewal application for the “Ethiopia- Emory TB Research Training Program (EETB-RTP)” include: 1) Continue to build relevant and sustainable research capacity in Ethiopia by aligning research training activities with the research priorities outlined in the Ethiopian MOH’s “National Tuberculosis Research Roadmap (2022-2026)”; 2) Support career development to promote the 7 professional characteristics of a translational scientist aligned with leadership in TB research; 3) Implement a new Advanced Training Track which will provide advanced grant writing instruction, mentor training, and leadership training to former Ethiopian Fogarty trainees to optimize their transition into independent investigators and mentors for the next generation of Ethiopian investigators; and 4) Enhance the diversity of the Ethiopian TB biomedical workforce by continuing to increase the number of women engaged in TB research.

PI_NAMEs: BLUMBERG, HENRY M (contact);BOBOSHA, KIDIST ;KEMPKER, RUSSELL RYAN

PROJECT_TERMS: career development;Cause of Death;Characteristics;Clinical Research;Country;COVID-19;COVID-19 impact;Doctor of Philosophy;Drug resistance in tuberculosis;Ethiopia;Ethiopian;Funding;Generations;Goals;Grant;Health;HIV;HIV/TB;Infectious Agent;Influentials;innovation;Institution;Instruction;International;Investigation;Leadership;Mentors;next generation;Peer Review;programs;Public Health;Publications;Research;Research Infrastructure;Research Institute;Research Personnel;Research Training;Secure;success;Training;Training Activity;Training and Infrastructure;Training Programs;Translational Research;translational scientist;Tuberculosis;Universities;Woman;Writing

PROJECT_TITLE: Ethiopia-Emory TB Research Training Program


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: COLLEGE PARK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: Project Narrative In this supplement proposal we build on a unique randomized controlled trial of foster care as an alternative for institutional care based in Bucharest, Romania. This valuable sample of children is being studied when participants are 22 years of age to examine the long-term consequences of early adversity and early intervention, as well as the effects of positive caregiving during adolescence on brain development, psychopathology, and competent functioning in young adulthood. We are requesting support for our staff for six months to complete data collection on the sample.

PI_NAMEs: FOX, NATHAN A (contact);NELSON, CHARLES ALEXANDER;ZEANAH, CHARLES HENRY

PROGRAM_OFFICER_NAME: GARVEY, MARJORIE ANN

PROJECT_TERMS: 21 year old;Address;Adolescence;Adolescent;Adult;Affective;Age Years;anti social;antisocial behavior;Anxiety;Behavior;Behavioral;Brain;brain shape;Buffers;Caregivers;caregiving;Caring;Child;Child Development;Childhood;Cognition;Cognitive;cognitive control;cognitive function;Competence;Coupled;COVID-19;Data;Data Collection;deprivation;Development;early childhood;early experience;Early Intervention;early life adversity;Education;Electroencephalography;emerging adult;emerging adulthood;Emotional;emotional functioning;Emotions;Environment;executive function;Exhibits;experience;Exposure to;foster care;Friendships;higher education;improved;Independent Living;Individual;infancy;Infant;Influentials;Institution;Institutionalization;Internal Capsule;Intervention;Life;Link;longitudinal design;Magnetic Resonance Imaging;Marketing;Measures;Mediating;Mediator;Mental Depression;Mental Health;Moods;neglect;neural;Neurobiology;neuroimaging;novel;Outcome;Participant;Play;prepuberty;Process;prospective;Psychopathology;Psychoses;Psychosocial Deprivation;Randomized;Randomized, Controlled Trials;Research Domain Criteria;Rewards;Risk;Role;Romania;Sampling;Seminal;Shapes;skills;social;Social Functioning;social relationships;Structure;Substance abuse problem;substance use;therapy design;Time;transition to adulthood;treatment as usual;trial design;white matter;young adult

PROJECT_TITLE: The Effects of Early Psychosocial Deprivation on Mental Health in Early Adulthood- COVID Supplement


PHR: Not Applicable no PHR

PI_NAMEs: MCMAHON, MOIRA MEI (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: Doctor of Philosophy;Funding;United States National Institutes of Health

PROJECT_TITLE: MSPP NIH MD/PhD Funding Application

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-U (22)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Head and Spine Injury

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE Even in the healthy aging brain there is a progressive decline in cognitive capabilities and vascular health, yet paradoxically brain energy consumption is close to normal. Our goal is to understand how the loss of vascular health impacts the accumulation in tissue of metabolic nutrients and waste products, which may interfere with brain function. Achieving this goal is expected to have broad impact to guide potential interventions to improve or preserve brain health in aging and beyond, including neurological conditions such as dementia, stroke, traumatic brain injury and cancer.

PI_NAMEs: MANGIA, SILVIA  (contact);ROTHMAN, DOUGLAS LYLE

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Address;Age;age related;Aging;aging brain;awake;Behavioral;Blood;Blood capillaries;blood glucose regulation;Blood Vessels;Brain;brain dysfunction;brain health;Brain Mapping;Brain region;brain tissue;Calibration;Carbon Dioxide;cerebral capillary;Cerebrovascular Circulation;cerebrovascular health;Cerebrum;Cognitive;cognitive function;connectome;Coupling;Data;Data Set;Dementia;dementia risk;density;Elderly;Electroencephalography;Energy consumption;Functional Magnetic Resonance Imaging;Glucose;glucose metabolism;glucose production;glycogen metabolism;Goals;Health;healthy aging;high risk;Homeostasis;Human;imaging study;improved;in vivo;Intervention;Lead;Literature;Magnetic Resonance Imaging;Malignant neoplasm of brain;Maps;Measurement;Measures;Mediating;Metabolic;Metabolism;Methodology;Modeling;neuroimaging;Neurologic;Neurons;neurovascular coupling;novel;Nutrient;Oxygen;pH Homeostasis;Photic Stimulation;Positron-Emission Tomography;preservation;Production;prospective;Protons;Reporting;Research;respiratory;Rest;Signal Transduction;Stroke;Testing;Time;tissue mapping;Tissues;Traumatic Brain Injury;Validation;Waste Products;young adult

PROJECT_TITLE: Homeostatic modeling of functional neuroimaging data in humans: a novel methodology to obtain brain maps of tissue pCO2, pO2 and pH in aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-Q (81)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Comparative Effectiveness Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Patient Safety;Primary Health Care;Rare Diseases;Tuberculosis

ORG_CITY: LIMA

ORG_COUNTRY: PERU

ORG_FIPS: PE

ORG_NAME: SOCIOS EN SALUD SUCURSAL PERU

PHR: PROJECT NARRATIVE. The purpose of this research is to confirm that the current treatment regimen for isoniazid-resistant tuberculosis (the most common drug-resistant tuberculosis) is well tolerated, has few side effects, and meets the WHO recommended efficacy target (90 percent treatment success). It will also assess blood concentrations of the most important drugs in the regimen to consider making dose adjustments that improve efficacy and safety. If the regimen is safe and effective, its duration could be reduced by adjusting doses; alternatively, exposure to specific drugs could be reduced or doses adjusted to improve efficacy while avoiding safety concerns.

PI_NAMEs: MENDOZA, ALBERTO  (contact)

PROGRAM_OFFICER_NAME: LAUGHON, BARBARA E

PROJECT_TERMS: Adult;Adverse event;Aftercare;alternative treatment;bactericide;Blood;Cause of Death;Centers for Disease Control and Prevention (U.S.);Clinical;Clinical Research;clinical risk;clinically significant;cohort;Collaborations;Communicable Diseases;Country;COVID-19;Dangerousness;Data;design;Disease;dosage;Dose;Drug Kinetics;Drug resistance in tuberculosis;Early treatment;Effectiveness;effectiveness evaluation;Enrollment;Environment;Ethambutol;Exposure to;Florida;follow-up;Foundations;Funding;gastrointestinal;Genome;Guidelines;Health;Hepatotoxicity;High Prevalence;Home;improved;Individual;Infectious Agent;Institution;isoniazid;Isoniazid resistance;Laboratories;Levaquin;Location;Measures;medical examination;medical schools;Meta-Analysis;metropolitan;Minimum Inhibitory Concentration measurement;Molecular;Monitor;Multidrug-Resistant Tuberculosis;Mutation;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;Nested Case-Control Study;Observational Study;Organism;Outcome;Participant;Patient Recruitments;Patients;Periodicals;Persons;Peru;Peruvian;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacovigilance;Phenotype;Plasma;Predisposition;Prevalence;Primary Care;primary health center;prospective;Prospective cohort;Public Sector;Pyrazinamide;Recommendation;Regimen;Relapse;Reporting;Research;Research Infrastructure;Resistance;Rifampicin resistance;Rifampin;Risk;Safety;safety assessment;Sampling;Scientific Societies;side effect;Sputum;success;Target Populations;Telephone;Testing;Toxic effect;Treatment Failure;Treatment outcome;Treatment Protocols;treatment response;treatment risk;Tuberculosis;tuberculosis drugs;tuberculosis treatment;United States National Institutes of Health;Universities;Work;World Health Organization

PROJECT_TITLE: Treatment of isoniazid-resistant tuberculosis: closing evidence gaps on safety, effectiveness, and pharmacokinetics of the standard regimen

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 SAS-W (J1)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Immunization;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Despite effective prevention tools, the annual incidence of new HIV-1 infections remains high, emphasizing the need for a vaccine. This proposal introduces an innovative approach using deep learning to design immunogens computationally, expanding structural design possibilities to generate gp120 core immunogens that more closely resemble the pre-fusion gp120 and assess their potential to elicit potent B-cell responses for broadly neutralizing antibodies. This research will provide valuable insights into new antigen design techniques and their application in HIV-1 vaccine strategies.

PI_NAMEs: ALDON, YOANN ;PANCERA, MARIE  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJALI

PROJECT_TERMS: Address;Adjuvant;alpha helix;Animals;Antibodies;Antibody Response;Antigen Presentation;Antigens;Attention;B cell repertoire;B-Cell Activation;B-Lymphocytes;Binding;Binding Sites;biophysical properties;Cell Ontogeny;Cells;Characteristics;Clinical Trials;Complement 4b;Complex;Core Protein;Data;deep learning;design;Development;Elements;Engineering;env Gene Products;Epitopes;Evaluation;Flow Cytometry;Fostering;Germ Lines;HIV 1 Envelope Protein gp120;HIV Envelope Protein gp120;HIV-1;HIV-1 vaccine;Human;Immune response;Immunization;Immunize;immunogenic;immunogenicity;improved;In Vitro;in vivo;Incidence;Infection;innovation;insight;Investigation;Kinetics;Knock-in Mouse;Light;Mammalian Cell;Membrane;Memory B-Lymphocyte;Messenger RNA;Monoclonal Antibodies;mouse model;mRNA delivery;nanoparticle;nanoparticle delivery;neutralizing antibody;novel;Pathway interactions;Polishes;preservation;Prevention;Process;Property;Protein Engineering;Proteins;Regimen;Research;Research Proposals;response;Role;screening;Shapes;Structure;Structure of germinal center of lymph node;Techniques;Testing;tool;Transgenic Mice;vaccine development;vaccine strategy;Vaccinee;Vaccines;Vertebral column

PROJECT_TITLE: Deep Learning-based Protein Design of HIV-1 Env GP120 Core Immunogens for CD4 Binding Site Germline Targeting

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ADMINISTERING_IC: DP

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

ORG_STATE: NC

PHR: PROJECT NARRATIVE Reducing disparities in the burden of chronic disease requires tools to support policy makers’ and communities’ understanding of which health-related policies, practices, or programs (PPP) could effectively and cost-effectively improve health, mortality, and equity outcomes. Building on our prior work developing chronic disease and economic models for the Centers for Disease Control and Prevention’s National Center for Chronic Disease Prevention and Health Promotion, we will develop an interactive web-based simulation model of six chronic diseases (heart disease, stroke diabetes, cancer, chronic kidney disease, and Alzheimer’s disease) that allows users to explore the impacts of PPPs on chronic disease incidence and disparities over the next 5 to 30 years. The model will produce results at local, state, and national levels of the impacts of using PPPs to address disparities by race/ethnicity, age, income, education, urban versus rural status, and sex, thus encouraging the use of community-based participatory approaches to confront SDOH and chronic disease disparities.

PI_NAMEs: ALLAIRE, BENJAMIN  (contact)

PROJECT_TITLE: RFA-DP-23-001, Simulation Model of Interventions Linking Evidence to SDOH (SMILES)


ADMINISTERING_IC: IP

IC_NAME: NATIONAL CENTER FOR IMMUNIZATION AND RESPIRATORY DISEASES

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE This research study will use economic survey methods to collect data on public/parent/patient preferences for vaccine outcomes and vaccination programs. Using this information, the CDC will be better able to measure the value of future vaccination programs and to design strategies to increase uptake of vaccination.

PI_NAMEs: PROSSER, LISA A. (contact)

PROJECT_TITLE: RFA-IP-23-007, Collaborative Surveys to Provide Inputs into Vaccine-Related Economic Evaluations


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Complementary and Integrative Health;Hematology;Immunotherapy;Nanotechnology;Orphan Drug;Rare Diseases

ORG_CITY: DALLAS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Narrative  We will develop an oxygen- and tissue depth-independent nano-phototherapy platform using nanophotosensitizers to treat cancer and bone lesions. The research will include a method to deliver enormous amounts of nanoparticles to tumors, destroy cells that support cancer cells, and explore if combined eradication of cancer and supporting cells will improve treatment outcome.

PI_NAMEs: ACHILEFU, SAMUEL  (contact)

PROGRAM_OFFICER_NAME: GRODZINSKI, PIOTR

PROJECT_TERMS: absorption;Adrenal Cortex Hormones;Affect;Award;Binding;Biological;Biological Availability;bone;Bone Marrow;Bone Matrix;Bortezomib;cancer cell;cancer imaging;cancer therapy;CAR T cell therapy;Carbon;Cell Death;cell dimension;Cells;chemotherapy;Cherenkov Radiation;clinical translation;Clinical Treatment;Clonal Expansion;Combined Modality Therapy;Complex;Coupled;cytotoxic;Data;Dimensions;Disease;Disease-Free Survival;Dose;Drug Delivery Systems;Drug resistance;effective therapy;Encapsulated;Engineering;Environment;Event;Exhibits;field study;Fluorine;fluorodeoxyglucose;Fracture;Funding;Glucose Transporter;Grant;Hematologic Neoplasms;Hematopoietic Neoplasms;High Dose Chemotherapy;Human;human disease;Hypoxia;Image;imaging agent;Immunomodulators;Immunosuppression;improved;in vivo;Infection;Intervention;Intravenous;Lesion;Light;Lipids;Liver;Lung;Malignant - descriptor;Malignant Neoplasms;Mediating;Medical;Medicine;Metals;Methods;Modality;Molecular;Monoclonal Antibodies;Multiple Myeloma;nano;nanomaterials;nanomedicine;nanoparticle;nanoparticle delivery;nanoscale;nanoscience;Nanotechnology;nanotechnology platform;nanotherapy;Natural regeneration;neurotoxicity;novel;novel therapeutic intervention;Nucleic Acids;Organelles;Osteolysis;Outcome;Oxidation-Reduction;Oxygen;Paper;Patients;Penetration;Peripheral Nervous System Diseases;Pharmaceutical Preparations;Photosensitizing Agents;Phototherapy;Plasma Cells;prevent;Process;Prodrugs;Production;Progression-Free Survivals;Property;Proteasome Inhibitor;Proteins;Quality of life;Quantum Dots;Radioisotopes;Radiolabeled;Radiopharmaceuticals;Reactive Oxygen Species;regenerative;Relapse;relapse patients;Research;Residual Neoplasm;Resistance;Science;Seminal;side effect;Signal Pathway;Site;Solid Neoplasm;Source;spatiotemporal;Spleen;stem;Stromal Cells;Supporting Cell;Surface;systemic toxicity;Technology;Testing;Therapeutic;Therapeutic Effect;therapy outcome;Thrombocytopenia;Tissues;titanium dioxide;titanocene;Toxic effect;Transducers;Transferrin;Treatment outcome;treatment response;treatment strategy;tumor;tumor growth;Ultraviolet Rays

PROJECT_TITLE: NANOPHOTOSENSITIZERS FOR REGENERATIVE PHOTOTHERAPY

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: This research is relevant for Veterans, as stroke is one of the leading causes of long-term disability in Veterans. An estimated 15,000 Veterans suffer a stroke each year. A novel rehabilitation treatment option developed as a result of this research has the potential to reduce the consequences of stroke for Veterans. Therefore, the proposed research is expected to contribute to providing Veterans with better post-stroke rehabilitation care with improved performance for activities of daily living.

PI_NAMEs: SEO, NA JIN  (contact)

PROJECT_TERMS: Activities of Daily Living;Acute;Address;Animals;arm;Articular Range of Motion;assistive robot;Caring;Compensation;cost estimate;design;Educational Status;effectiveness evaluation;Ensure;exoskeleton;Feedback;Finger joint structure;Fingers;follow-up;Freedom;Future;Goals;grasp;Hand;hand dysfunction;Hand functions;hand rehabilitation;hand therapy;Human;Impairment;improved;individual patient;Individuation;innovation;inpatient service;Intervention;joint mobilization;Joints;Laws;Learning;Left;Leisures;Long term disability;Macaca;Measures;military veteran;Monkeys;Movement;Neurologic;novel;Outcome;Participant;Patient Participation;patient safety;Patients;Pattern;Performance;post stroke;prevent;programs;Quality of life;Recovery;recruit;Rehabilitation therapy;rehabilitative care;Research;Robot;robot control;robot rehabilitation;Robotics;Self Care;Stroke;stroke model;stroke patient;stroke survivor;Study models;System;Testing;Time;tool;Torque;Training;Upper Extremity;Veterans;Work

PROJECT_TITLE: Feasibility of Using Maestro Hand Exoskeleton in Post-stroke Hand Rehabilitation to Improve Joint Coordination

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases;Rare Diseases

ORG_CITY: GREENVILLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: EAST CAROLINA UNIVERSITY

PHR: PROJECT NARRATIVE  Non-cholera Vibrio species are a significant threat to human health through food poisoning and wound infection exacerbated by biofilms. This project will use structural and biochemical techniques to probe a central component of a highly relevant biofilm regulatory pathway. The resulting information will provide us with greater insight into the mechanisms governing this system and advance the field by broadening our understanding of how bacteria regulate biofilm formation.

PI_NAMEs: MILTON, MORGAN EILISE (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: Address;antagonist;Bacillus subtilis;Bacteria;bacterial community;Bacterial Infections;bacterial resistance;Binding;Biochemical;Biophysics;Communities;Complex;Data;Disease;Drug resistance;Environment;experimental study;Extracellular Matrix;Food Poisoning;Food Safety;Funding;Future;Gene Expression;Genetic;genetic analysis;genetic approach;genetic regulatory protein;Genetic Transcription;Goals;Health;Homologous Gene;host-associated biofilms;Human;human pathogen;Infection;innovation;insight;K22 Award;Knowledge;Microbial Biofilms;model organism;Molecular;novel;nucleoside triphosphatase;Outcome;Pathogenesis;Pathway interactions;Phosphorylation;Play;Polysaccharides;Positioning Attribute;Process;Production;protein complex;Protein Family;protein protein interaction;protein structure;Proteins;Public Health;Publications;Regulation;Regulatory Pathway;Research;Research Personnel;Resources;response;Role;Sigma Factor;Signal Pathway;Structure;Subgroup;sulfate transporter;Surface;Symbiosis;System;Techniques;Tertiary Protein Structure;Therapeutic Intervention;United States;Vibrio;Vibrio fischeri;Vibrio Infections;Vibrio parahaemolyticus;Vibrio vulnificus;Virulence;Work;Wound Infection

PROJECT_TITLE: Regulatory mechanism of novel host-relevant biofilm formation protein in non-Cholera Vibrio species

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Lung;Neurosciences;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prescription Drug Misuse;Substance Misuse

ORG_CITY: MORRISTOWN

ORG_NAME: PARK THERAPEUTICS, INC.

ORG_STATE: NJ

PHR: NARRATIVE The U.S. is experiencing a crisis of opioid misuse, addiction, and overdose; in the most recent year, there were over 100,000 drug-related overdose deaths, 75% of which involved opioids. There is a clear, urgent need for improved pharmacotherapies for the treatment of opioid use disorder (OUD) that do not possess a high potential for abuse, physical dependence, or overdose. Park Therapeutics is developing cebranopadol as a safe and potentially effective alternative treatment for OUD.

PI_NAMEs: CICCOCIOPPO, ROBERTO ;GREENWALD, MARK K;GRIECO, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: HUBNER, CAROL B

PROJECT_TERMS: abuse liability;Acute;addiction;Address;Affect;Affinity;Agonist;alternative treatment;analog;antagonist;Apnea;attenuation;Behavior;Binding;Breathing;Buprenorphine;Clinical;Clinical Data;Clinical Research;cocaine self-administration;Confidence Intervals;craving;Crossover Design;Data;Death Rate;Development;Dosage Forms;Dose;Double-Blind Method;Drug Metabolic Detoxication;effective therapy;efficacy evaluation;efficacy study;Evaluation;experience;Fentanyl;fentanyl self-administration;Future;Heroin;Hour;Human;Hydromorphone;improved;Incidence;Intravenous;intravenous administration;Maintenance;Measures;Mediating;meetings;Methadone;Morphine;morphine administration;Motor;Naltrexone;nociceptin;Opiate Addiction;opiate tolerance;Opioid;opioid epidemic;opioid injection;opioid misuse;opioid overdose;Opioid Peptide;Opioid Receptor;opioid use;opioid use disorder;opioid user;opioid withdrawal;Oral;Oral Administration;ORL1 receptor;Outcome Measure;Overdose;overdose death;overdose risk;Oxycodone;Oxygen;Pain;Participant;Patients;Peptide Receptor;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phase;Physical Dependence;Placebos;Precipitation;preclinical safety;preclinical study;primary outcome;programs;Randomized;Rattus;receptor;Receptor Activation;Recreation;Regimen;Respiratory physiology;Risk;Safety;safety study;Schedule;Self Administration;Signs and Symptoms;Solid;synthetic drug;Testing;Therapeutic;Tramadol;Treatment Efficacy;Ventilatory Depression;verbal;Visual;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Development of cebranopadol, a potent dual MOP/NOP agonist, for the treatment of Opioid Use Disorder (OUD)

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Medication Development Research Study Section[NIDA-L]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: THE HOST PATHOGEN MAP INITIATIVE 2.0 OVERALL NARRATIVE The Host-Pathogen Map Initiative (HPMI) 2.0 applies a state-of-the-art suite of systems biology approaches to study the molecular interactions of bacterial and viral respiratory pathogens with the host cell machinery in disease-relevant primary cell models. In the previous funding period, these approaches identified several new host factors with unexpectedly opposite roles in resistance to viral and bacterial pathogens. Here, we will uncover the protein-protein and genetic interactions of the most important pulmonary infectious agents of humans, Mycobacterium tuberculosis (Mtb) and SARS-CoV-2 - including currently circulating variants of concern omicron and delta - to deeply probe the functional roles of host and pathogen factors in infection and disease progression and identify therapeutically actionable targets for host-directed therapies, circumventing the risk of pathogen treatment resistance. Finally, the integration of such network information with clinical information will allow us to determine predictors of disease severity.

PI_NAMEs: KROGAN, NEVAN J (contact)

PROGRAM_OFFICER_NAME: KWON, KEEHWAN

PROJECT_TERMS: 2019-nCoV;3-Dimensional;Alveolar Macrophages;Animal Model;Anti-viral Agents;Antibiotics;Automobile Driving;Bacterial Genes;Bacterial Genome;Binding;Bioinformatics;Biological Markers;Biological Sciences;cell dimension;Cell model;cell type;Cells;Cellular Assay;Chromosome Mapping;Clinical;Clinical Data;Clinical Research;clinically relevant;co-infection;cohort;Collaborations;Collection;combinatorial;Communicable Diseases;Communication;Complex;COVID-19;COVID-19 patient;Critical Pathways;cytokine release syndrome;Data;data integration;data management;Data Set;deep learning;Disease;Disease Outcome;disease prognosis;Disease Progression;disorder risk;drug efficacy;Environment;equity, diversity, and inclusion;Event;Fostering;Funding;Gene Combinations;Genetic;genetic analysis;Genetic Screening;genome wide association study;Goals;Growth;Heterogeneity;Human;Human Genome;improved;In Vitro;in vivo;Infection;Infectious Agent;Inflammatory;Inflammatory Response Pathway;Influenza;Information Networks;innate immune mechanisms;Innate Immune Response;innovation;Integration Host Factors;Intervention;Leadership;lectures;Lung;Macrophage;Maps;Mission;Modality;Modeling;Molecular;Mutation;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;network models;new technology;novel;novel therapeutic intervention;Organoids;Outcome;outreach;parainfluenza virus;pathogen;Pathogenesis;pathogenic bacteria;pathogenic virus;Pathogenicity;Pathway interactions;Patients;peripheral blood;permissiveness;Pharmaceutical Preparations;Plasma;Population;Post-Translational Protein Processing;Predisposition;programs;protein complex;Protein Secretion;Proteins;Proteome;Proteomics;Regimen;Resistance;Resources;Respiration;Respiratory Disease;respiratory pathogen;Respiratory syncytial virus;Respiratory Therapy;Respiratory Tract Infections;respiratory virus;Risk;Risk Factors;RNA Viruses;Role;Sampling;SARS-CoV-2 infection;SARS-CoV-2 variant;Series;Serum;Severity of illness;Signal Transduction;spatiotemporal;structural biology;Structure;success;Susceptibility Gene;symposium;System;Systems Biology;targeted treatment;Technology;Therapeutic;therapeutic target;therapy resistant;tool;transcriptome;transcriptomics;Tuberculosis;Universities;variants of concern;Vietnam;Viral;Viral Proteins;viral resistance;Viral Respiratory Tract Infection;Virus Diseases;virus identification;Virus Replication;whole genome

PROJECT_TITLE: HPMI: Host Pathogen Mapping Initiative


NIH_SPENDING_CATS: Infectious Diseases

PROJECT_TERMS: Advocate;Area;Basic Science;Bioinformatics;Clinical Research;Collaborations;Communicable Diseases;Communication;Communities;data management;Dedications;Development;Educational workshop;Electronic Mail;Ensure;Environment;equity, diversity, and inclusion;Evaluation;Event;experience;Faculty;Feedback;Fostering;Foundations;Future;Goals;Grant;Human Resources;Infectious Diseases Research;interest;International;Joints;Leadership;Maintenance;Maps;meetings;member;Mission;National Institute of Allergy and Infectious Disease;next generation;outreach;pathogen;podcast;Productivity;Publications;Reporting;Research;Research Personnel;Research Project Grants;Resource Sharing;Schedule;Scientist;Series;symposium;Systems Biology;Training;underserved community;United States National Institutes of Health;Vietnam;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Genetics;Infectious Diseases;Networking and Information Technology R&D (NITRD)

PI_NAMEs: SALI, ANDREJ  (contact)

PROJECT_TERMS: Affect;bacterial genetics;Bioinformatics;Biological;candidate validation;Cell model;Cells;Chromosome Mapping;Computer software;Data;Data Analyses;data and analysis portal;data exchange;data integration;data management;Data Set;Databases;Development;digital object identifier;Disease;disease prognosis;Ecosystem;Ensure;Genetic;genetic information;genome wide association study;Human;Infrastructure;Integration Host Factors;Intuition;Journals;Link;Maps;Mission;Modeling;Molecular;network models;novel;Ontology;pathogen;Pathway interactions;Peer Review;Performance;Proteins;Proteomics;Publications;Publishing;Reproducibility;Research;Research Personnel;Resources;respiratory virus;Site;Software Tools;Source;Supercomputing;targeted treatment;tool;transcriptomics;Tuberculosis;Visual;Visualization;web portal;web site

PROJECT_TITLE: CORE 1: Data Management and Bioinformatics Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung

PI_NAMEs: SWANEY, DANIELLE L (contact)

PROJECT_TERMS: 2019-nCoV;3-Dimensional;A549;Acetylation;Affinity Chromatography;airway epithelium;Alveolar;Back;Bacterial Infections;beamline;Biochemical;Bioinformatics;Biological Assay;Biological Sciences;Cell Line;Cell Separation;Cells;Classification;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communicable Diseases;Complex;Core Facility;crosslink;Cryoelectron Microscopy;Crystallography;Data;data management;Dedications;Deuterium;Disease;Disease Outcome;Education;electron crystallography;Equipment;Generations;Genetic;genetic approach;Genetic Screening;genome-wide;Genomics;Goals;Human;Hydrogen;IL17 gene;Infection;Infrastructure;innovation;insight;Integration Host Factors;interest;knock-down;Knock-out;Label;Laboratories;Macrophage;Maps;Mass Spectrum Analysis;Measures;Mentors;method development;Microscopy;model building;Modeling;Molecular;Mus;Mycobacterium tuberculosis;new technology;new therapeutic target;Organoids;outreach;pathogen;Pathogenesis;Patients;Peripheral;Phosphorylation;Physiological;Post-Translational Protein Processing;protein complex;protein expression;protein protein interaction;protein purification;Proteins;Proteomics;Research Personnel;Research Project Grants;Research Support;Resolution;Resources;respiratory;Respiratory Disease;respiratory pathogen;respiratory virus;Sampling;Serum;Services;Severity of illness;Signal Transduction;Site;Small Interfering RNA;structural biology;Structure;System;Systems Biology;targeted treatment;Techniques;Technology;therapeutic development;three dimensional cell culture;tissue culture;tool;Training;Validation;Variant;variants of concern;Viral;Virus Diseases;Visualization;Work;X-Ray Crystallography

PROJECT_TITLE: CORE 2: Technology Core


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Natural Products

ORG_CITY: SALT LAKE CITY

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE All organisms produce a bevy of small molecules, many of which are not required for primary metabolic processes but confer selective advantage to the producing organism in complex biological environments. The biosynthetic pathways to these molecules often involve complex enzymatic transformations, which in many cases remain to be discovered. Understanding the biosynthetic pathways to these small molecule natural products is an important step in gleaning their role in physiology, with an ultimate goal of introducing them in the clinic.

PI_NAMEs: BANDARIAN, VAHE  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TITLE: Discovery and mechanisms of biosynthetic enzymes


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

PHR: PROJECT NARRATIVE – UCSF LIVER CENTER The Liver Center is a community of scientists performing research on a variety of topics pertinent to liver health and disease. Some study normal liver, including normal liver development and function; others study how livers become diseased, and use this insight to develop new therapies. Liver Center scientists cover the complete spectrum of liver disease research, from basic cell biology to clinical trials and studies of the impact of social and environmental factors on the outcome of liver diseases. The Liver Center supports these lines of research by facilitating access to research technologies, promoting exchange of knowledge and ideas, and launching innovative projects by gifted scientists.

PI_NAMEs: WILLENBRING, HOLGER  (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Acceleration;Aphorisms;Applications Grants;Autoimmune Diseases;Award;base;biobank;Bioinformatics;Biology;Biomedical Research;Blood;Board Certification;California;career development;cell growth;Cell Separation;Cells;Cellular biology;Clinical;Clinical Research;Clinical Trials;Collaborations;Collection;combat;Communication;Communities;Consultations;Critiques;Databases;Dedications;Development;Digestive System Disorders;Direct Costs;Disease;Educational workshop;Environmental Risk Factor;Equilibrium;Equipment;faculty support;falls;feasibility research;Fibrosis;Fostering;Functional disorder;Funding;Genes;Gifts;Goals;Grant;Growth;Growth and Development function;Health;Hepatocyte;Hepatology;Histology;Homeostasis;Human;Human Resources;Image;Immune response;Immunology;improved;Infiltration;Infrastructure;innovation;insight;interest;Investments;Joints;Knowledge;Laboratories;Leadership;Liver;liver development;Liver diseases;liver function;liver injury;liver metabolism;Liver Regeneration;Malignant Neoplasms;Medical center;member;Mentorship;Metabolism;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;Newsletter;novel therapeutics;Nutritional Science;Organ;organ growth;Outcome;Patients;Physicians;professor;programs;prospective;Publications;Recovery Support;Research;Research Personnel;Research Project Grants;Research Support;Resources;response;San Francisco;Scientist;senior faculty;Services;single-cell RNA sequencing;social factors;Specimen;square foot;symposium;Technology;Tissues;Toxicology;Translational Research;translational scientist;Transplantation;Universities;Viral;Vision;Visit;web site;Woman

PROJECT_TITLE: UCSF Liver Center


NIH_SPENDING_CATS: Digestive Diseases;Liver Disease

PHR: PROJECT NARRATIVE Please refer to the Project Narrative in the OVERALL section of the application.

PI_NAMEs: MAHER, JACQUELYN J. (contact)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Rare Diseases;Tuberculosis

PI_NAMEs: IDEKER, TREY  (contact)

PROJECT_TERMS: 2019-nCoV;Affect;Alveolar Macrophages;Architecture;Binding;Biological;Biological Markers;Cells;Cellular biology;Cellular Structures;Chromosome Mapping;Clinical;clinical translation;cohort;combinatorial;Communicable Diseases;Complex;computer framework;confocal imaging;CRISPR/Cas technology;Cryoelectron Microscopy;Data;Data Analyses;deep learning;deep learning model;design;Development;Disease Outcome;DNA Sequence Alteration;Epithelial Cells;Evaluation;Expert Systems;Generations;Genes;Genetic;Genetic study;genetic variant;genome-wide;Human;Immunofluorescence Immunologic;improved;Infection;interest;Knowledge;Laboratories;Learning;Lung;Machine Learning;machine learning model;Maps;Medicine;Methodology;Methods;Modeling;Molecular;molecular modeling;Molecular Structure;Mutation;Mycobacterium tuberculosis;Organelles;pathogen;Pathway interactions;Phenotype;Population;precision medicine;predictive modeling;protein complex;Protein Dynamics;Protein Isoforms;Proteins;Proteomics;Resistance;Risk;SARS-CoV-2 infection;Severity of illness;structural biology;Structural Models;Structural Protein;Structure;System;Techniques;three-dimensional modeling;Training;transfer learning;Vietnam;Virulence Factors;Virus;Work

PROJECT_TITLE: CORE 3 : Modeling Core


NIH_SPENDING_CATS: Clinical Research;Hematology;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Sepsis

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Sepsis endotypes are biological subtypes defined by distinct pathophysiologic mechanisms and identified by corresponding biomarkers. Endotypes may respond differently to sepsis treatment. Moving the science of sepsis endotypes from offline to online learning in the electronic health record has the potential to broaden our understanding of sepsis biology, improve causal inference, and advance precision care.

PI_NAMEs: SEYMOUR, CHRISTOPHER WARREN (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: American;Artificial Intelligence;Award;Biological;Biological Markers;Biology;Blood;Cessation of life;clinical decision-making;clinical translation;Collection;Computational Biology;E-learning;Early treatment;Electronic Health Record;Ethers;Funding;health information technology;Hospitalization;Immunology;improved;improved outcome;Inflammation;insight;Integrated Health Care Systems;Laboratories;Learning;Machine Learning;machine learning method;Mentorship;Methods;microbiome;Molecular;National Institute of General Medical Sciences;Outcome;pathogen;Patients;personalized care;point of care;Policies;pressure;programs;Psychological reinforcement;Science;Scientist;Sepsis;Systems Biology;targeted treatment;Testing;Time;treatment optimization;treatment response;Uncertainty;Work

PROJECT_TITLE: Sepsis online: learning while doing to understand biology and treatment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Liver Disease

PROJECT_TERMS: Acceleration;Antibodies;arm;Biology;Cell Separation;Cells;Cellular biology;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Client;Collaborations;Color;Communities;Consultations;Cytometry;design;Development;disease model;Equipment;experimental study;Flow Cytometry;General Hospitals;Grant;Hepatocyte;Hepatology;Human;Hybrids;Immune;Immunity;Immunologics;Immunology;improved;Individual;Infiltration;innovation;instrument;Laboratories;Leadership;Liver;Liver diseases;member;Phase;Population;Productivity;Reporting;Research;Research Personnel;Resources;San Francisco;Scientist;Services;single-cell RNA sequencing;Source;Specimen;Structure;Technical Expertise;Techniques;Technology;Universities;University resources;Update

PROJECT_TITLE: Liver Cell Isolation, Analysis & Immunology Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

PI_NAMEs: COX, JEFFERY S (contact)

PROJECT_TERMS: aerosolized;Affect;Alveolar;Alveolar Macrophages;antimicrobial;Bacterial Genes;bacterial genetics;Bacterial Genome;Bacterial Infections;Behavior;Bioinformatics;Biological Assay;Cell model;Cells;Clinical;clinically relevant;co-infection;Collaborations;Collection;Complex;Coupled;Critical Pathways;cytokine;Data;Data Collection;data integration;data management;data modeling;Data Set;Disease;Etiology;Event;Fetal Liver;gene discovery;Gene Targeting;Generations;Genes;Genetic;Genetic Determinism;Genetic Transcription;Genetically Engineered Mouse;genome editing;genome wide association study;Growth;Heterogeneity;Human;human disease;Human Genome;human model;human tissue;Immune response;in vivo;in vivo Model;induced pluripotent stem cell;Infection;Inflammatory;Inflammatory Response;Innate Immune Response;Innate Immune System;insight;Integration Host Factors;Interferon Type I;Knockout Mice;Link;Lung;Macrophage;Mammalian Genetics;Maps;Mass Spectrum Analysis;Medical Genetics;Modeling;Molecular;molecular dynamics;monocyte;mouse model;Mycobacterium tuberculosis;Nature;novel;Outcome;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Phagocytes;Post-Translational Protein Processing;protein protein interaction;Proteomics;recruit;Research;response;Role;Sampling;Severity of illness;Shapes;Signal Pathway;Speed;Study models;synergism;Systems Biology;Technology;Testing;therapeutic target;Tissues;transcriptome sequencing;transcriptomics;Tuberculosis;Variant;Vietnam;Viral;Virus Diseases;Work

PROJECT_TITLE: PROJECT 1: Identification of host and bacterial pathways that control tuberculosis pathogenesis in humans


NIH_SPENDING_CATS: Neurosciences;Rare Diseases

ORG_CITY: GREENWOOD

ORG_NAME: GREENWOOD GENETIC CENTER

PHR: PROJECT NARRATIVE Maintaining the normal activity of lysosomes, the recycling centers of the cell, is essential for human health, as evidenced by the many rare disorders caused by defects in the formation or function of lysosomes. How lysosomal dysfunction leads to the symptoms of these disorders is poorly understood. Our long-term goal is to define those disease mechanisms, and use that information to identify new therapeutic strategies.

PI_NAMEs: STEET, RICHARD  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Address;Affect;Anabolism;Animal Model;Automobile Driving;Biogenesis;bone;Carbohydrates;cardiogenesis;Cartilage;cartilage development;cathepsin K;Cathepsins;cell type;Cells;Cholesterol;Chondrogenesis;Cysteine;Defect;Development;Disease;disease model;Embryo;Enzymes;Etiology;Event;Exocytosis;extracellular;Extracellular Space;Functional disorder;Genetic;genetic manipulation;Glycosaminoglycan Degradation Pathway;Glycosaminoglycans;Goals;Grant;Growth Factor;Health;Homeostasis;Human;Hydrolase;I-Cell Disease;Impairment;improved;in vivo;innovation;Investigation;Link;Lipomucopolysaccharidoses;Lysosomal Storage Diseases;Lysosomes;mannose 6 phosphate;Mediating;model organism;Modeling;Molecular;Monitor;mutant;myelination;Neurons;novel;novel therapeutic intervention;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Peptide Hydrolases;pharmacologic;Phenotype;Phosphotransferases;Polysaccharides;Rare Diseases;receptor;Recycling;Signal Transduction;skeletal;Sorting;stem;Sulfate;Symptoms;System;Testing;TFE3 gene;Therapeutic;Tissues;tool;Transgenic Organisms;Zebrafish

PROJECT_TITLE: Pathogenic Mechanisms of Lysosomal Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(80)S]


PI_NAMEs: GRENERT, JAMES P. (contact)

PROJECT_TITLE: Liver Tissue Analysis Core


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Infectious Diseases;Influenza;Lung;Orphan Drug;Pediatric;Pneumonia and Influenza;Prevention;Rare Diseases;Tuberculosis

PI_NAMEs: OTT, MELANIE MARIA (contact)

PROJECT_TERMS: 2019-nCoV;3-Dimensional;5 year old;access disparities;Acute respiratory infection;Affect;Animal Model;Anti-viral Agents;Bioinformatics;Biological;bronchial epithelium;burden of illness;candidate identification;cell dimension;Cell Line;Cell model;Cells;Cessation of life;Child;Clinical;Clinical Data;clinically relevant;Cloning;Clustered Regularly Interspaced Short Palindromic Repeats;Computer Models;COVID-19 pandemic;COVID-19 severity;CRISPR screen;cytokine;Data;data integration;data management;Data Set;Dependence;Development;Disease;Disease Outbreaks;Economics;Engineering;Epithelial Cells;Event;Evolution;experimental study;Failure;flexibility;follow-up;functional genomics;Future;future pandemic;Gene Expression Profile;Genetic;genetic analysis;genetic technology;genome wide association study;genome wide screen;genome-wide;genomic data;Global Change;Health;health care availability;Human;In Vitro;in vivo;Individual;Inequity;Infection;Inflammatory;Influenza A virus;Influenza B Virus;influenzavirus;innovation;insight;Integration Host Factors;knock-down;Knock-out;Lung;Maps;Mass Spectrum Analysis;Measures;Modeling;mortality;mouse model;Mycobacterium tuberculosis;novel;novel therapeutic intervention;Open Reading Frames;Organoids;overexpression;parainfluenza virus;pathogen;Pathogenesis;Pathogenicity;Pathway Analysis;Pathway interactions;Patients;Phosphorylation;Post-Translational Protein Processing;prevent;protein protein interaction;Protein Secretion;Proteins;Proteomics;Public Health;receptor;Recombinants;Recording of previous events;Resistance;Resistance development;Respiration;respiratory;Respiratory Disease;respiratory infection virus;respiratory pathogen;Respiratory syncytial virus;Respiratory Tract Infections;respiratory virus;reverse genetics;RNA Viruses;Role;Sampling;SARS-CoV-2 B.1.1.529;SARS-CoV-2 genome;SARS-CoV-2 infection;SARS-CoV-2 variant;Sequence Deletion;Serum;Signal Transduction;social;System;Systems Biology;targeted treatment;Technology;Terminator Codon;Testing;Therapeutic Intervention;Therapeutic Monoclonal Antibodies;therapeutically effective;transcriptome;transcriptome sequencing;transcriptomics;Tuberculosis;underserved area;Vaccination;vaccine access;Vaccinee;Validation;variants of concern;Viral;Viral Pathogenesis;Viral Proteins;Viral Respiratory Tract Infection;Virus;Virus Diseases;virus host interaction;Virus Inhibitors;Virus Replication

PROJECT_TITLE: PROJECT 2: Determine clinically relevant host-viral dependency networks for respiratory infections including SARS-CoV-2


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Headaches;Machine Learning and Artificial Intelligence;Neurosciences;Pain Research;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Prevention;Traumatic Head and Spine Injury

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: Project Narrative: Currently, there are no adequate methods to predict whether an individual with post-traumatic headache (PTH) will have resolution of headaches during the acute phase or will have persistence of PTH (PPTH). The goal of this study is to identify a prognostic biomarker signature that will accurately predict the persistence of PTH using clinical data and structural and functional brain neuroimaging data collected in the semi-acute post-concussion phase. The ability to predict who will develop PPTH would help clinicians determine how aggressively to manage patients with PTH during the acute phase and would allow for optimizing enrollment into PTH clinical trials by preferentially enrolling individuals who are likely to have PTH persistence.

PI_NAMEs: CHONG, CATHERINE DANIELA (contact)

PROGRAM_OFFICER_NAME: ARUDCHANDRAN, RAMACHANDRAN NMN

PROJECT_TERMS: Acute;Age;Algorithms;Biological Markers;biomarker development;biomarker signature;Brain;Brain Concussion;Brain imaging;Brain Injuries;brain magnetic resonance imaging;Characteristics;Clinical;clinical biomarkers;Clinical Data;clinical decision-making;clinical practice;Clinical Trials;cohort;common symptom;Data;Deformity;demographics;detection sensitivity;Development;Diagnostic;disability;Early identification;early phase clinical trial;Early treatment;Enrollment;experience;Goals;Headache;Healthcare;high risk;Image;imaging biomarker;Individual;individual patient;Innovative Therapy;Intention;Knowledge;Laboratories;Machine Learning;machine learning algorithm;machine learning model;Magnetic Resonance;Magnetic Resonance Imaging;Measures;Medical History;Methods;Military Personnel;Modeling;neuroimaging;neuroimaging marker;non-opioid analgesic;Patients;Pattern;Perfusion;Persons;Pharmaceutical Preparations;Phase;Phenotype;Population;Post-Traumatic Headaches;post-traumatic symptoms;predictive marker;predictive modeling;prevent;Prognostic Marker;prognostic model;prognostication;Questionnaires;Recommendation;Recording of previous events;Recovery;research clinical testing;Resolution;Scanning;sex;side effect;Speech;Symptoms;Testing;Thick;Toxic effect;Translating;Traumatic Brain Injury;Weight;white matter;Work

PROJECT_TITLE: Biomarker Signature to Predict the Persistence of Post-Traumatic Headache


NIH_SPENDING_CATS: Biotechnology;Data Science;Digestive Diseases;Genetics;Human Genome;Liver Disease

ORG_STATE: CA

PI_NAMEs: WANG, BRUCE MAO ZHENG (contact)

PROJECT_TERMS: Acceleration;Attention;Bioinformatics;California;Cells;Client;Collaborations;Consultations;Contracts;cost comparison;Data;Data Analyses;Data Science;Data Scientist;Data Set;data visualization;Development;Elements;Environment;Equipment;experience;Experimental Designs;Fluorescent in Situ Hybridization;Gene Expression;Genes;genome sciences;Genomics;Goals;Hepatocyte;Hepatology;Hour;Infrastructure;innovation;Knowledge;laboratory equipment;Liver;Mainstreaming;Mediation;member;Methodology;Methods;Modeling;Patients;Phase;Pilot Projects;Positioning Attribute;Price;Publications;recruit;Research;Research Personnel;response;Services;single molecule;single-cell RNA sequencing;skills;Stains;Structure;success;System;Testing;Time;Tissues;Training;transcriptome sequencing;transcriptomics;Universities;Work

PROJECT_TITLE: Liver Gene Analysis Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative  The Clinical Proteomic Tumor Analysis Consortium (CPTAC) seeks to expand the proteogenomic approach developed during the past 10 years to more cancer types and to translational research focusing on clinically relevant problems. This application proposes an integrative proteogenomic data analysis center (iPGDAC) built on our established expertise and resources. The overarching goal of the iPGDAC is to accelerate the translation of cancer proteogenomic data into better understanding of cancer biology and improved cancer treatment.

PI_NAMEs: ZHANG, BING  (contact)

PROGRAM_OFFICER_NAME: HILTKE, TARA

PROJECT_TERMS: Acceleration;Address;Amino Acid Sequence;Area;Base Sequence;Benchmarking;Biological;Biological Assay;Biological Markers;Biological Models;Cancer Biology;cancer diagnosis;cancer therapy;cancer type;candidate identification;candidate marker;Center for Translational Science Activities;Clinical;clinical center;Clinical Data;clinical translation;Clinical Trials;clinically relevant;Collaborations;Communities;computerized data processing;computerized tools;Data;Data Analyses;data integration;data quality;Data Set;deep learning;Disease;epigenomics;functional genomics;Funding;genetic variant;genomic aberrations;genomic predictors;Genomics;Goals;Human;Immunophenotyping;improved;Individual;insight;Knowledge;Leadership;machine learning algorithm;Malignant Neoplasms;Mass Spectrum Analysis;Molecular;natural language;Network-based;novel;Pathway Analysis;Pathway interactions;patient prognosis;Patients;Peptides;Phase;Phenotype;Play;Portraits;Post-Translational Modification Site;Post-Translational Protein Processing;predictive modeling;Prognosis;programs;protein biomarkers;Proteins;proteogenomics;Proteomics;Publishing;Quality Control;Resources;Role;Sampling;Specific qualifier value;success;targeted biomarker;Techniques;tool;tool development;transcriptomics;Translational Research;Translations;treatment response;tumor;tumor microenvironment;verification and validation;web portal;Work;working group

PROJECT_TITLE: iPGDAC, An Integrative Proteogenomic Data Analysis Center for CPTAC


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Infectious Diseases;Nanotechnology;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: ATHENS

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: Bacterial infections and in particular Mycobacterium tuberculosis infections (TB) cause millions of deaths each year. All anti-TB drugs have serious limitations due to the lack of timely antibacterial effect, their inability to eliminate slow growing “persister-like” cells, human toxicity over extended the treatment regimens required, the emergence of multidrug resistant strains, the lack of new effective pan-antibacterial drugs, and because the cost of extended drug therapies can bankrupt a poor family. Herein we explore DectiSomes, a transformative new drug design and conceptual framework in which antibacterial drug-loaded liposomes are coated with pathogen receptors, targeting them to bacterial cells and increasing drug efficacy by orders of magnitude.

PI_NAMEs: MEAGHER, RICHARD BRIAN (contact)

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: Address;Aerosols;Amphotericin B;Animal Model;Anti-Bacterial Agents;anti-fungal agents;Anti-Infective Agents;Antibiotic Therapy;Antimycobacterial Agents;Area;Aspergillus fumigatus;aspirate;Bacterial Infections;Binding;Biological Assay;C-Type Lectins;Candida albicans;Capsid Proteins;CD209 gene;Cell Density;Cell Wall;Cells;Cessation of life;Chronic;Complex;cost;crosslink;Cryptococcus neoformans;Dangerousness;Data;dectin 1;design;Development;disease model;Dose;Drug Delivery Systems;Drug Design;drug development;drug efficacy;Drug resistance;drug resistance development;Drug toxicity;effective therapy;experience;experimental study;extracellular;Family;Functional disorder;fungus;Genus Mycobacterium;Granuloma;Helminths;Human;Immune signaling;Immune system;Immunocompromised Host;improved;In Vitro;in vivo;Individual;Infection;Infectious Skin Diseases;innovation;intravenous injection;Kinetics;Laboratories;Laser Scanning Microscopy;Life;lipid nanoparticle;lipomannan;Liposomes;Lung;Lung infections;Medical Device;medical implant;member;Metabolic;Microbial Biofilms;Modeling;mouse dectin-2;mouse model;Multi-Drug Resistance;Mus;mycobacterial;Mycobacterium avium;Mycobacterium avium Complex;Mycobacterium Infections;Mycobacterium tuberculosis;Mycobacterium ulcerans;mycolactone;non-tuberculosis mycobacteria;novel therapeutics;Oligonucleotides;Oral;Organ;Outcome;pathogen;Pathogenesis;pathogenic bacteria;pathogenic fungus;Pathogenicity;Patients;Pharmaceutical Preparations;Pharmacotherapy;Pilot Projects;Polysaccharides;Population;Protein Chemistry;Protein Isoforms;Protozoa;Publications;Publishing;receptor;Refractory;Research;resistant strain;Rhodamine;Rifampin;skin lesion;Technology;Testing;therapeutic nanoparticles;Thick;Tissues;Toxic effect;Toxin;Treatment Protocols;Tuberculosis;tuberculosis drugs;Variant

PROJECT_TITLE: Targeted pan-antibacterial liposomes to control pathogenic mycobacteria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DDR-C(01)]


PI_NAMEs: LAI, JENNIFER C. (contact)

PROJECT_TERMS: Acceleration;Appointment;Basic Science;biobank;Biological Specimen Banks;Biomedical Research;Biometry;Blood specimen;Charge;Clinical;Clinical Research;Clinical Sciences;Collaborations;Collection;Complex;Consultations;Data;Databases;Dedications;Dimensions;Disease;Ensure;Environment;Epidemiology;Faculty;Freezing;Grant;Hepatology;Human;human subject;human tissue;Infrastructure;Institution;investigator-initiated translational research;Liver;Liver diseases;liver transplantation;machine learning method;member;Modeling;Modification;Names;patient registry;Patients;Positioning Attribute;professor;programs;prospective;Publications;Qualifying;Research;Research Design;Research Personnel;Research Support;Resources;response;Role;Science;Services;Specimen;statistics;System;Time;Tissue Banks;Tissue Sample;Tissues;Translational Research;Universities

PROJECT_TITLE: Patient-Facing Research Core


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Complementary and Integrative Health;Infectious Diseases;Natural Products

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE Actinomycete bacteria have historically been an incredibly rich source of useful chemical compounds, often called natural products. These natural products include antibiotics, antifungals, and anti-cancer compounds. Pathogen resistance to many antibiotics is on the rise, however, the pace of antibiotics discovery has slowed. We now know that natural product biosynthesis by actinomycetes is often triggered during microbial interactions. We will study how social interactions between actinomycetes lead to biosynthesis of natural products at the molecular genetic and systems levels, and use these insights to leverage microbial interactions for novel antimicrobial discovery.

PI_NAMEs: TRAXLER, MATTHEW F (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Actinobacteria class;Anabolism;anti-cancer;anti-fungal agents;Antibiotics;antimicrobial;Antineoplastic Agents;Bacteria;Bacterial Infections;Bacterial natural products;Cells;Chemicals;Clinical;Cues;Foundations;Future;Gene Expression;Genetic;Goals;GTP-Binding Proteins;Individual;insight;Knowledge;Lead;Metabolism;Microbe;microbial;microorganism interaction;Modeling;Molecular;Molecular Genetics;Natural product discovery;Natural Products;novel;pathogen;Production;protein activation;Regulation;Reporting;Research;Resistance;Signal Transduction;social;Social Interaction;Source;Streptomyces coelicolor;System;Translating;Work

PROJECT_TITLE: Connecting specialized metabolism to social cues in actinomycete bacteria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Sleep Research

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Sleep and circadian (24-hour) rhythms are fundamental functions of human beings that promote physical, mental, and cognitive health, but show substantial disparities across the population. Given the recent explosion of scientific knowledge about sleep and circadian rhythms, the scientific workforce in these areas remains small and insufficiently diverse. The aim of this grant is to train a new and diverse generation of sleep and circadian rhythms researchers, including doctoral, predoctoral, and short-term scholars.

PI_NAMEs: BUYSSE, DANIEL J. (contact);FRANZEN, PETER L

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TITLE: Translational Research Training in Sleep and Circadian Science

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease

PROJECT_TERMS: Academic support;Adult;Autoimmune Hepatitis;Award;base;Basic Science;Biotechnology;Categories;Childhood;Clinical;clinical investigation;Clinical Research;cohort;cost;Coupled;Dedications;diversity and equity;Ensure;Equilibrium;Faculty;Female;Financial Support;follow-up;Funding;Gastroenterology;Genes;Genetic;Goals;Grant;Hepatology;Incubators;innovation;Institution;interest;Investments;Journals;Leadership;Letters;Liver;liver transplantation;Longevity;Measures;medical schools;Medicine;member;Nature;non-alcoholic fatty liver disease;outreach;Patients;Price;Process;Productivity;professor;programs;Publications;recruit;Research;Research Personnel;Research Project Grants;Resources;Scientist;sequencing platform;Services;single-cell RNA sequencing;Source;success;Talents;Techniques;Technology;Time;translational medicine;Translational Research;Transplant Recipients;Work

PROJECT_TITLE: Pilot & Feasibility Grant Program


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Tobacco;Tobacco Smoke and Health;Women's Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Current eligibility guidelines for lung cancer screening exclude a greater percentage of high-risk African Americans than whites. To remedy this, we will build a lung cancer risk prediction model for African Americans and use the new model to identify racially equitable screening strategies in the US population. Finally, we will produce a web-based tool to aid personalized risk prediction at shared decision-making visits to equitably help African Americans assess whether lung screening is desired.

PI_NAMEs: ALDRICH, MELINDA  (contact);BLUME, JEFFREY D.

PROGRAM_OFFICER_NAME: CHOLLETTE, VERONICA

PROJECT_TERMS: Accounting;Address;African American;African American population;Age;age group;Algorithms;Biometry;black women;Calibration;cancer epidemiology;cancer risk;Cessation of life;Clinical;Clinical Data;clinical implementation;cohort;Cohort Studies;Communities;community advisory board;community engaged approach;community engagement;comorbidity;Data;data harmonization;Decision Aid;design;Development;Diagnosis;Diagnostic;Eligibility Determination;Equity;Etiology;Exclusion;experience;Failure;Focus Groups;Guidelines;health disparity;high risk;improved;Individual;innovation;Knowledge;Life;low socioeconomic status;Lung;lung cancer screening;Machine Learning;machine learning algorithm;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Mission;Modeling;mortality;multi-ethnic;multidisciplinary;National Cancer Institute;National Health Interview Survey;Natural History;novel;Online Systems;patient oriented;Patients;personalized predictions;personalized risk prediction;Population;population based;Precision Health;Predictive Cancer Model;predictive modeling;predictive tools;Property;prospective;Prospective cohort;Provider;Public Health Informatics;Publishing;Race;racial difference;racial disparity;racial diversity;Racial Equity;real world application;Research;Risk;Risk Factors;risk prediction model;Rural;rural area;screening;Screening for cancer;screening guidelines;screening program;shared decision making;simulation;Smoking;Smoking Behavior;Smoking History;statistical and machine learning;Statistical Methods;Statistical Models;study population;Surveys;Techniques;Testing;Translating;United States;United States Preventative Services Task Force;urban area;Validation;Variant;Visit;web based decision aid;web-based tool;Woman;Women's Health;Work

PROJECT_TITLE: Addressing racial disparities in lung cancer screening

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


PROJECT_TITLE: Enrichment Program


NIH_SPENDING_CATS: Cancer

ORG_CITY: CHICAGO

ORG_DEPT: SURGERY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE We propose the development of the COllaborative Northwestern Surgical Oncology Research Training (CONSORT) program to develop the next generation of surgical oncology-focused scientists. The CONSORT program is anchored by our successful history of two-year dedicated research training by (1) a highly accomplished team of Northwestern University researchers and clinicians to provide tailored mentoring for the trainees and (2) the unique 15-year partnership in training surgical research trainees in conjunction with the American College of Surgeons’ Cancer Programs. The CONSORT program will be a national leader in increasing the pipeline of qualified surgical oncology physician and PhD scientists who go on to faculty positions, with independently funded research agendas, making seminal contributions to the field, and mentoring their own trainees, while also delivering high-quality, compassionate care to cancer patients.

PI_NAMEs: ACKERMANN, RONALD T.;KHAN, SEEMA AHSAN (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Research Training;Surgical Oncology

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Emerging Infectious Diseases;Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Rare Diseases

PHR: Project Narrative Kaposi's sarcoma-associated herpesvirus (KSHV) causes several human cancers including Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease. These malignancies inflict morbidity and mortality to the society in US and worldwide. This project will investigate the mechanisms regulating the replication of KSHV by RNA modifications, and identify potential therapeutic targets for developing novel prevention and treatment approaches.

PI_NAMEs: GAO, SHOU-JIANG  (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;African;Alternative Splicing;base;Binding;Binding Proteins;Biogenesis;carcinogenesis;Cell Physiology;cell type;Cells;clinically relevant;Communities;Country;CRISPR/Cas technology;crosslink;Data Set;epitranscriptome;Etiology;expectation;Funding;gain of function;Genetic Transcription;Genome;Goals;Herpesviridae Infections;Highly Active Antiretroviral Therapy;HIV Seropositivity;Human;Human Herpesvirus 8;Immunity;Immunoprecipitation;Individual;innovation;insight;Intervention;Kaposi Sarcoma;knock-down;Knock-out;Life Cycle Stages;loss of function;lytic replication;Malignant Neoplasms;Maps;Mediating;Messenger RNA;metaplastic cell transformation;Methyltransferase;MicroRNAs;Modeling;Modification;Morbidity - disease rate;mortality;mRNA Translation;Multicentric Angiofollicular Lymphoid Hyperplasia;neoplastic cell;new technology;novel;novel therapeutics;Nuclear Export;Nucleotides;overexpression;Pathogenesis;Patients;Phase;Point Mutation;Poly(A)+ RNA;Population;Prevention;primary effusion lymphoma;Prognostic Marker;programs;Protein Overexpression;Proteins;Reader;Reagent;Regulation;Resolution;reverse genetics;RNA;RNA Degradation;RNA immunoprecipitation sequencing;RNA Splicing;RNA Viruses;Role;Site-Directed Mutagenesis;Societies;Stains;System;Testing;therapeutic target;Time;Transcript;transcriptome;Translations;tumor;tumorigenesis;Viral;Virus Diseases;Virus Latency;Virus Replication;Work

PROJECT_TITLE: Regulation of KSHV replication by N6-methyladenosine (m6A)

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Moving the field of cancer population science forward will require enhancing our ability to translate basic and clinical advances into populations, communities and policy. Training a new generation of cancer population scientists to meet these challenges and opportunities will improve future cancer outcomes.

PI_NAMEs: ADAMS-CAMPBELL, LUCILE LAUREN;O'NEILL, SUZANNE C. (contact);SCHWARTZ, MARC D

PROJECT_TERMS: Malignant Neoplasms;Population Sciences;Training Programs

PROJECT_TITLE: Training Program in Cancer Population Science (CaPS)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PHOENIX

ORG_NAME: ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER

PHR: Project Narrative The proposed studies will provide novel information on the role of microglia in disease mechanisms and neuronal dysfunction in C9orf72 patients clinically diagnosed with frontotemporal dementia (FTD). While microglia activation is known to occur in this patient population through postmortem autopsy studies, a much better understanding is needed regarding the extend of microglia-neuron co-regulation and the existence or absence of non-cell autonomous disease mechanisms similar to what has been described for astrocyte and motor neurons in other neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). The proposed studies will provide novel opportunities for drug target identification and future drug discovery efforts with the hope of identifying novel therapeutics for these affected patient populations.

PI_NAMEs: HUENTELMAN, MATT ;SATTLER, RITA  (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Amyotrophic Lateral Sclerosis;Area;Astrocytes;Autopsy;Brain;Brain region;C9ALS;c9FTD/ALS;C9ORF72;Candidate Disease Gene;cell cortex;Cell Differentiation process;Cell Line;cell type;Cells;chemokine;Clinical;clinical diagnosis;Coculture Techniques;Communication;cytokine;Data;Data Set;Dementia;density;Department of Defense;Development;Dipeptides;Disease;disease phenotype;drug discovery;Drug Targeting;Etiology;Executive Dysfunction;executive function;Expression Profiling;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Funding;Future;Gene Expression Profile;Gene Expression Profiling;Genes;genetic profiling;Gliosis;Goals;Hot Spot;Human;human induced pluripotent stem cells;Immune;Immunohistochemistry;Impaired cognition;In Vitro;Induced pluripotent stem cell derived neurons;Investigation;Knowledge;Label;Laboratories;Lysosomes;Maintenance;Measures;Microglia;Modeling;Molecular;molecular phenotype;Morphology;Motor Neurons;Mutation;Nerve Degeneration;neural;Neurodegenerative Disorders;Neurofibrillary Tangles;neuron loss;Neuronal Dysfunction;neuronal excitability;neuronal survival;Neurons;neuropathology;novel;novel therapeutics;Outcome;Pathogenesis;Pathologic;Pathology;patient derived induced pluripotent stem cells;patient population;patient subsets;Patients;PGRN gene;Phagocytes;Phenotype;pluripotent stem cell differentiation;Prefrontal Cortex;Process;Property;Prosencephalon;protein expression;protein TDP-43;Proteins;Reporting;RNA;Role;single nucleus RNA-sequencing;single-cell RNA sequencing;Specificity;Symptoms;Synapses;System;Time;Tissue-Specific Gene Expression;Tissues;transcriptome;transcriptome sequencing;Validation;Variant

PROJECT_TITLE: Microglia contribution to disease pathogenesis in C9orf72 ALS/FTD

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]