NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: Antimicrobial resistance is a life-threatening public concern. The major goal of this research is to design, synthe- size and investigate a new class antimicrobial agents derived from AApeptide biomaterials with novel mecha- nisms. Thus, a new generation of antibiotic agents combating antibiotic-resistant bacteria pathogens will be re- sulted from our work.

PI_NAMEs: CAI, JIANFENG  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: analog;Anti-Bacterial Agents;anti-microbial drug;Antibiotic Resistance;Antibiotics;antimicrobial;Antimicrobial Resistance;Bacteria;Bacterial DNA;Bacterial Infections;bacterial resistance;bactericide;Binding;Biochemical;Biocompatible Materials;Biophysics;clinically relevant;combat;Combating Antibiotic Resistant Bacteria;Complex;Data;Derivation procedure;design;Development;Drug resistance;drug resistant pathogen;emerging antibiotic resistance;Enzymes;Exhibits;experimental study;Fluorescence Microscopy;Fluoroquinolones;Foundations;Generations;Goals;Gram-Negative Bacteria;Host Defense Mechanism;Hydantoins;improved;In Vitro;in vivo;Infection;innovation;interest;Lead;Life;Literature;Membrane;methicillin resistant Staphylococcus aureus;Methods;Modeling;Modification;Molecular;mouse model;Multi-Drug Resistance;Mus;National Institute of General Medical Sciences;Nitrofurantoin;novel;novel antibiotic class;novel strategies;Outcome;pathogenic bacteria;Peptides;Probability;Pseudomonas aeruginosa;Publishing;Research;Resistance;Ribosomes;Series;small molecule;sound;Testing;Therapeutic;Thigh structure;Time;Toxic effect;Urinary tract infection;Work;World Health Organization

PROJECT_TITLE: Antimicrobial agents derived from AApeptide biomaterials

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Genetic Testing;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Acute leukemia (AL), a cancer of the blood, has variable prognosis, treatment response and survival depending on the specific subtype, which is characterized by genetic alterations, but current standard-of-care testing takes 2 to 4 weeks to fully characterize and subtype an AL and requires highly skilled staff as well as multiple expensive instruments and reagents. We have developed an ultrarapid (same day sample to reporting) assay using real-time long read DNA sequencing to achieve faster and more cost-effective detection of AL mutations/fusions and build upon our current computational methods and software tools to support reproducible data analysis and enable interactive interpretations for biomedical users. We propose to first expand this assay to add additional targets for AL prognostication and therapy guidance, then to validate an optimized CSRL assay and bioinformatics workflow, and finally to run a pilot trial to show feasibility of clinical implementation.

PI_NAMEs: YEUNG, CECILIA C (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, LOKESH

PROJECT_TERMS: Acute leukemia;Acute Myelocytic Leukemia;Allogenic;Bioinformatics;Biological Assay;Cancer Center;Characteristics;Chemistry;Chromosome abnormality;Clinic;Clinical;clinical decision-making;clinical implementation;Clinical Services;Clinical Trials;clinically actionable;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Computing Methodologies;cost;cost effective;cost efficient;Cytogenetics;Data;Data Analyses;Death Rate;design;Detection;detection method;Development;Devices;Diagnosis;Disease;DNA;DNA sequencing;Drug Targeting;Ensure;feasibility testing;Flow Cytometry;FLT3 gene;fusion gene;Gene Mutation;Genes;genomic profiling;Genomics;Goals;Guide RNA;Guidelines;Hematopoietic Neoplasms;Hematopoietic Stem Cell Transplantation;Hour;improved;Individual;instrument;JAK2 gene;Karyotype;Laboratories;leukemia;Libraries;Methodology;Methods;Molecular;Molecular Abnormality;Molecular Diagnosis;Molecular Profiling;Morphology;multiplex assay;Mutate;Mutation;nanopore;National Comprehensive Cancer Network;Newly Diagnosed;next generation sequencing;novel;NPM1 gene;Nucleic Acids;Oncologist;Outcome;Pathology;Patient Care;Patient-Focused Outcomes;Patients;Performance;Phase;Physicians;Pilot Projects;pilot trial;Polymerase Chain Reaction;Prediction of Response to Therapy;predictive marker;Preparation;Prognosis;prognostic;Prognostic Marker;prognostication;Protocols documentation;Reagent;Recommendation;Reporting;Reproducibility;Research Design;response;risk stratification;Running;RUNX1 gene;sample collection;Sampling;Selection for Treatments;Sensitivity and Specificity;single molecule;skills;Software Tools;Specimen;standard of care;Surveys;System;t(8;21)(q22;q22);targeted treatment;Technology;Testing;Time;TP53 gene;Training;treatment response;Tumor Burden;Variant;Visualization software

PROJECT_TITLE: Rapid Acute Leukemia Genomic Profiling with CRISPR enrichment and Real-time long-read sequencing


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: FRESNO

ORG_DEPT: CHEMISTRY

ORG_NAME: CALIFORNIA STATE UNIVERSITY FRESNO

ORG_STATE: CA

PHR: Narrative  We hypothesize that increasing AbcA1 and Ldlr while reducing ApoE with small molecules, will diminish and clear amyloid plaques from affected brains in Alzheimer’s disease. This proposal aims at the identification of new leads that correctly modulate the three proteins. The SuRE support will enable the PI to recruit, retain, train, and motivate undergraduate and graduate research students toward building research careers via higher education.

PI_NAMEs: MAITRA, SANTANU  (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Affect;Aging;Alzheimer's Disease;Amines;Amyloid;amyloid formation;amyloid pathology;analog;antagonist;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Apolipoproteins;appendage;Astrocytoma;ATP binding cassette transporter 1;ATP-Binding Cassette Transporters;Biological;Blood - brain barrier anatomy;Brain;brain cell;career;Carrier Proteins;Cell Line;chemical synthesis;Chemicals;Cholesterol;Dementia;Deposition;Drug Kinetics;Endocytosis;Enzyme-Linked Immunosorbent Assay;experimental study;extracellular;Future;Genes;genetic risk factor;Goals;Grant;higher education;Human;In Vitro;in vivo;Individual;Laboratories;Lead;Libraries;Link;Lipids;lipophilicity;Low Density Lipoprotein Receptor;medical schools;Modification;molecular mass;Mus;Nervous System Disorder;novel;overexpression;Pathogenesis;Pharmaceutical Preparations;pharmacophore;Phase;Play;Process;Production;Protein Isoforms;Proteins;recruit;replication factor C;Research;Role;scaffold;screening;Senile Plaques;small molecule;Structure-Activity Relationship;Student recruitment;Students;Sulfonamides;Therapeutic;Toxicology;Training;Transgenic Mice;undergraduate student;Underrepresented Students;Western Blotting

PROJECT_TITLE: Targeting AbcA1 and Ldlr production for the Discoveryof Alzheimer's disease Drugs


ADMINISTERING_IC: DK

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Maternal Health;Maternal Morbidity and Mortality;Neurosciences;Physical Activity;Physical Rehabilitation;Regenerative Medicine;Rehabilitation;Urologic Diseases;Women's Health Research

ORG_CITY: CLEVELAND

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CLEVELAND STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE This proposal aims to develop a biodegradable and implantable piezoelectric platform that can provide wireless, local, and on-demand mechano-electrical stimulation of pudendal nerve upon applied mechanical forces for postoperative stress urinary incontinence treatment. This unconventional approach will challenge the standard paradigm by modulating injured neurons and endogenous cells via local mechano-electrical cues created by rehabilitative exercise movements. In the long run, this piezoelectric platform technology has the potential to be synergistically combined with Kegel exercise to promote pudendal nerve regeneration and provide a positive impact on economic and societal needs of patients with stress urinary incontinence.

PI_NAMEs: UZ, METIN  (contact)

PROGRAM_OFFICER_NAME: KIRKALI, ZIYA

PROJECT_TERMS: Action Potentials;Affect;Anatomy;Anxiety;biomaterial compatibility;blind;Brain-Derived Neurotrophic Factor;Cell Survival;Cells;Clinic;Clinical;clinical translation;Cues;cytokine;Denervation;design;Deterioration;Discipline;Economic Burden;Economics;electric field;Electric Stimulation;Electrodes;Engineering;Exercise;exercise rehabilitation;experience;Exposure to;Feasibility Studies;flexibility;Generations;Health;Home;Hour;Human;Human Resources;Implant;implantation;In Vitro;in vivo;Incontinence;injured;Injury;innovation;Kegel exercise;Life;mechanical force;mechanical properties;Mechanics;Mental Depression;Metals;Methods;Microfluidics;Modeling;Motor Neurons;Movement;Muscle;Natural regeneration;Nerve;Nerve Entrapment;nerve injury;Nerve Regeneration;Neuronal Injury;Neurons;neurotrophic factor;Operative Surgical Procedures;Patients;Pelvic floor structure;Penetration;Performance;Physical activity;Polymers;Population;Postoperative Period;Pregnant Women;Prevalence Study;Property;prototype;Quality of life;Rattus;Recovery;Recovery of Function;regenerative;Rehabilitation therapy;reinnervation;Reporting;Research;response;Risk;Running;Safety;Schwann Cells;simulation;Site;Social isolation;Sphincter;stem cell therapy;Stress Urinary Incontinence;Stretching;success;Symptoms;technology platform;Testing;Therapeutic;Time;Tissues;Toxic effect;translational approach;Treatment Efficacy;Urethral sphincter;urinary;Urinary Incontinence;Urology;Vaginal delivery procedure;wireless;Woman

PROJECT_TITLE: Wireless mechano-electrical stimulation of pudendal nerve using piezoelectric platform for stress urinary incontinence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-W(05)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: BIOLOGY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative Neurodegenerative diseases are characterized by the presence of protein aggregates that result in dementias and movement disorders. Purification of amyloid filaments from the protein aggregates for structural studies has been challenging. An affinity purification method will be developed in this project to improve amyloid isolation and cryoEM structural studies for better understanding of the diseases.

PI_NAMEs: JIANG, WEN  (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: 3-Dimensional;Actins;Affinity;Affinity Chromatography;alpha synuclein;Alzheimer's Disease;American;Amino Acid Sequence;Amyloid;Amyloid beta-Protein;amyloid formation;Amyloid Proteins;amyloid structure;Area;Autopsy;Binding;Biological Assay;Brain;brain tissue;Buffers;Cell Culture Techniques;Cell model;Centrifugation;Cerebrospinal Fluid;Characteristics;Collagen;Column Chromatography;Congo Red;cost;Cryoelectron Microscopy;Dementia;density;Deposition;design;Detergents;Development;Diagnostic Procedure;Diagnostic Reagent;Disease;Disease Progression;Drug Design;Dyes;Economic Burden;Economics;Etiology;Exclusion;Exhibits;experimental study;Feasibility Studies;feasibility testing;Ferritin;Filament;Fluorescence;Fluorescent Probes;Freezing;graphene;histological specimens;Hour;Image;Immobilization;improved;In Vitro;in vivo;Individual;interest;Kinetics;Length;Life Expectancy;magnetic beads;Mass Spectrum Analysis;meter;Methods;Modernization;Molecular Conformation;monolayer;motor disorder;Movement Disorders;Nature;Neurodegenerative Disorders;neuropathology;Nuclear Magnetic Resonance;Oxides;Patients;Peptides;Pharmaceutical Preparations;Post-Translational Protein Processing;Preparation;preservation;prevent;Prions;Procedures;Property;protein aggregation;Protein Analysis;protein folding;protein purification;protein structure;Proteins;Recombinant Proteins;Recombinants;reconstruction;Reporting;Research Personnel;Resolution;Sampling;Senile Plaques;Severities;Societies;socioeconomics;Source;Specificity;structural biology;Surface;tau Proteins;technology development;Therapeutic;Thioflavin S;Time;tissue degeneration;Tissue Sample;tool;Ultracentrifugation;Vesicle;Width;Work;X-Ray Crystallography

PROJECT_TITLE: Affinity purification of cross-ß fibrils using immobilized thioflavin

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: DETROIT

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Nearly half of the adult U.S. population suffer from hypertension, a major risk factor leading to heart disease, stroke, and kidney failure. Combined intake of fructose and salt equivalent to three 12-oz cans of sugared soft drinks and ~6 gm of sodium raises blood pressure, induces prediabetes, and increases stiffness of the arteries, all strong predictors of cardiovascular morbidity and mortality. Our proposal investigates drug therapies that improve blood pressure, insulin sensitivity, and arterial stiffness in a preclinical model and provides insights into underlying causes leading to novel approaches at an early stage of these disorders and prevent frank disease.

PI_NAMEs: ROSSI, NOREEN F (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Ablation;Acute;Adult;Aging;Angiotensins;Animal Model;Aorta;arterial stiffness;Attention;attributable mortality;Baroreflex;Blood - brain barrier anatomy;Blood Pressure;blood pressure elevation;blood pressure reduction;Blood Vessels;Brain;cardiometabolism;Cardiovascular Diseases;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;Cessation of life;Chronic;Chronic disability;Chronic Kidney Failure;clinical practice;Clinical Research;Collaborations;Conscious;Consumption;Data;Deafferentation procedure;Denervation;Development;Diet;Diet Habits;dietary;disability;Disease;DOCA;Early Diagnosis;Early identification;effective therapy;Endothelium;Event;Exercise;exercise training;Fluorescein-5-isothiocyanate;food consumption;Fructose;Functional disorder;Glomerular Filtration Rate;Goals;Heart;Heart Diseases;Heart failure;heart function;high salt diet;Human;Hypertension;Impairment;improved;in vivo;indexing;Individual;Ingestion;insight;Insulin Resistance;insulin sensitivity;Intake;Interruption;Intervention;Kidney;Kidney Diseases;kidney dysfunction;Kidney Failure;Knowledge;Laboratories;Measurable;Measurement;Modeling;Morbidity - disease rate;mortality;Motivation;Musculoskeletal;Myocardial;Myocardial Infarction;Myography;Nerve;novel strategies;Oxidative Stress;Pain;pharmacologic;Pharmacotherapy;Physiologic pulse;Physiological;Population;Positioning Attribute;pre-clinical;Pre-Clinical Model;preclinical study;Prediabetes syndrome;pressure;prevent;Principal Investigator;programs;Publishing;Pulse Pressure;Rattus;receptor;renal artery;Renal Blood Flow;Renal function;Renin-Angiotensin System;Renin-Angiotensin-Aldosterone System;research clinical testing;Risk;Risk Factors;Rodent Model;salt intake;salt sensitive hypertension;screening;sex;sexual dimorphism;Societies;Sodium;Sodium Chloride;soft drink;Sprague-Dawley Rats;Stroke;Subfornical Organ;sweetened beverage;Sympathectomy;Sympatholytics;Symptoms;Systolic heart failure;Technology;Testing;Therapeutic Intervention;Time;TNFRSF1A gene;Translating;Tumor Necrosis Factor Receptor;Ultrasonography

PROJECT_TITLE: Impact of Dietary Fructose and High Salt Diet on Neurocardiovascular and Renal Function

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ED_INST_TYPE: OVERALL MEDICAL

ORG_CITY: COLLEGE STATION

ORG_DEPT: GENETICS

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

ORG_STATE: TX

PHR: Project Narrative The major histocompatibility complex (MHC) is critical for effective immune responses, but is deregulated in common malignancies, such as duodenal and colorectal cancer. Using cell culture, animal, and patient organoid approaches, this project repurposes standard-of-care clinical agents and a novel epigenetic drug candidate in the context of an evolving new paradigm for immune- based cancer interception in the gut. Increasing MHC expression according to the central hypothesis will enhance immune surveillance and foster clearing of precancerous lesions, at doses likely to be well-tolerated when translated to at-risk human subjects.

PI_NAMEs: DASHWOOD, RODERICK H (contact);VILAR SANCHEZ, EDUARDO

PROGRAM_OFFICER_NAME: MALONE, WINFRED F

PROJECT_TERMS: adaptive immune response;adenoma;Adenomatous Polyps;Animals;anti-cancer;Antibodies;Antigen Presentation;Antineoplastic Agents;ApcMin/+ mice;Apoptosis;Autologous;Binding;Biological Assay;Biological Markers;Biopsy;cancer cell;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Culture Techniques;cell killing;Cell Proliferation;Cell surface;Cell Survival;Cells;Cellular Structures;chemokine;Clinic;Clinical;clinical care;Clinical Research;clinical translation;Clinical Trials;Coculture Techniques;Colectomy;Colon;Colonic Neoplasms;Colonic Polyps;Colorectal Cancer;Complex;Coupled;Critiques;cytokine;Data;Diet;Dose;drug candidate;Drug Combinations;Duodenal Neoplasms;Duodenum;Duodenum Cancer;Ectoderm;Effectiveness;efficacy study;EGFR gene;Embryo;Epidermal Growth Factor Receptor;epigenetic drug;Epigenetic Process;Epithelium;Erlotinib;Eye;Familial Adenomatous Polyposis Syndrome;Female;Fostering;Future;Gene Expression;Genes;Genetic;Granzyme;Histocompatibility Antigens Class II;histone methylation;Histones;Human;human subject;Image;Immune;Immune Evasion;Immune response;Immune system;Immune Targeting;Immunologic Surveillance;inhibitor;innovation;insight;Interferons;Intervention;Knockout Mice;Lesion;Major Histocompatibility Complex;male;Malignant Neoplasms;member;men;Modeling;Modification;Mus;mutant;neoplastic;next generation;Non-Steroidal Anti-Inflammatory Agents;Normal Cell;novel;novel strategies;Operative Surgical Procedures;Oral;Oral Administration;Organoids;overexpression;Patients;Peptides;perforin;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Pharmacotherapy;Phase;Polycomb;polyposis;Polyps;pre-clinical;Pre-Clinical Model;premalignant;Proteins;Rattus;Reader;Receptor Inhibition;Recommendation;recruit;Regulation;Research;Resistance;response;response biomarker;Risk;Risk Reduction;Safety;Signal Transduction;standard of care;stem;Sulindac;T-Lymphocyte;Testing;Therapeutic Equivalency;Time;Tissues;Titrations;Toxic effect;transcriptomics;Translating;tumor;Tumor Escape;Up-Regulation;Western Blotting;Woman

PROJECT_TITLE: Immunoepigenetic targeting of MHC regulators in FAP

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ADMINISTERING_IC: AA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Excessive drinking is a significant public health problem that may be powerfully driven by what people learn and remember about their experiences with alcohol. The proposed research uses functional neuroimaging and neuroendocrine assays to investigate the cognitive and neurobiological mechanisms by which binge/heavy drinkers form different types of memories about alcohol-related cues. We will explore how the engagement of multiple neural memory systems is modulated by glucocorticoids and drinking history, and determine whether these processes predict real-world drinking behavior.

PI_NAMEs: GOLDFARB, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: KUMAR, SHAILESH

PROJECT_TERMS: Acute;acute stress;addiction;Address;Affective;Alcohol consumption;alcohol cue;alcohol exposure;alcohol memory;alcohol response;Alcoholic beverage heavy drinker;Alcoholism;Alcohols;Amygdaloid structure;Attenuated;Behavior;Behavioral;Biological;biological adaptation to stress;Biological Assay;blood oxygen level dependent;career;career development;Cellular Phone;Chronic Disease;Cognitive;cognitive neuroscience;collaborative environment;Computer Models;Corpus striatum structure;craving;Cues;Data;design;Development;Dorsal;drinking;drinking behavior;Ecological momentary assessment;Emotional;experience;flexibility;Functional Magnetic Resonance Imaging;Glucocorticoids;Goals;Growth;Habits;Heavy Drinking;high risk drinking;Hippocampus;Hormones;Human;Hydrocortisone;hypothalamic-pituitary-adrenal axis;Impairment;improved;Intervention;Investigation;Laboratories;Learning;Light;Link;Measurement;Measures;medical schools;member;Memory;Memory impairment;memory process;memory retrieval;men;Mentors;Methods;Modeling;Monitor;National Institute on Alcohol Abuse and Alcoholism;neural;neural circuit;neurobiological mechanism;Neurobiology;neuroimaging;neuromechanism;Neurosecretory Systems;novel;Participant;Persons;Play;Population;Prefrontal Cortex;Process;programs;Protocols documentation;Public Health;Recording of previous events;Reporting;Research;response;Response to stimulus physiology;Retrieval;Risk;Role;Salivary;Scientist;Signal Transduction;social;Stress;System;Testing;Time;Training;training opportunity;Woman;Work

PROJECT_TITLE: Neuroimaging multiple memory processes, glucocorticoids and alcoholism risk

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: LA JOLLA

ORG_NAME: LA JOLLA INSTITUTE FOR IMMUNOLOGY

PHR: PROJECT NARRATIVE This proposal will determine the impact of enteroviral infections on beta cells in a new model of living pancreatic slices (in vitro) and the surrounding compartments and their respective role in the initiation of autoimmune type 1 diabetes. The goals of this proposal are to determine if tissue-resident macrophages under viral infection initiate an autoimmune reaction and if other pancreatic compartments could play a role in T1D onset.

PI_NAMEs: BENKAHLA, MEHDI  (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: 3-Dimensional;Antibodies;Autoimmune;autoimmune pathogenesis;Autoimmunity;Autologous;Autophagocytosis;autoreactive T cell;autoreactivity;Beta Cell;Blood;blood glucose regulation;Capsid Proteins;Cell Death;Cell Physiology;Cell Survival;cell type;Cells;Cellular Stress;Child;chronic autoimmune disease;Coculture Techniques;Coxsackie Viruses;Coxsackievirus Infections;Data;Development;Diabetes Mellitus;diabetes pathogenesis;Disease;Enterovirus;Environment;Environmental Risk Factor;Epidemiology;Etiology;Exocrine pancreas;Genetic Predisposition to Disease;Goals;Homeostasis;Human;Human Biology;Human Pathology;human tissue;Immune;immune activation;Immune mediated destruction;Immune system;In Vitro;Inbred NOD Mice;Incidence;Infection;Insulin;insulin dependent diabetes mellitus onset;insulin secretion;Insulin-Dependent Diabetes Mellitus;islet;islet cell antibody;Islets of Langerhans;Link;Macrophage;Metabolic stress;meter;Modeling;monocyte;Morphology;Mus;Neurons;non-diabetic;Pancreas;Patients;Peripheral Blood Mononuclear Cell;Physiology;Play;Predisposition;Reaction;Reporting;Research;response;Role;Signal Transduction;single-cell RNA sequencing;Slice;Structure of beta Cell of islet;T cell response;T-Cell Activation;T-Lymphocyte;Thick;Tissue Sample;Tissues;trend;Viral;viral RNA;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Dynamic analysis of beta cell attacks in response to virus infection in Human pancreatic slices


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Immunotherapy;Precision Medicine;Radiation Oncology;Skin Cancer

ORG_CITY: Aurora

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE  We propose to develop novel theranostic 203Pb/212Pb-DOTA-Linker-Nle-CycMSHhex(KD) peptides for imaging-guided melanocortin-1 receptor-targeted alpha radionuclide therapy (MC1R-TART) and then combine MC1R-TART with immune checkpoint inhibitors (ICIs) for melanoma treatment, enhancing the opportunity for cure to metastatic melanoma patients.

PI_NAMEs: MIAO, YUBIN  (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: Acids;Affinity;alternative treatment;anti-CTLA4;anti-PD-1;anti-PD-L1;Award;Biodistribution;BRAF gene;Clinical Trials;CTLA4 gene;curative treatments;design;Dose;dosimetry;Evaluation;FDA approved;first-in-human;Future;Human;Image;image guided;Imaging Device;Immune checkpoint inhibitor;Immune system;improved;Inbred BALB C Mice;Incidence;insight;Kidney;Legal patent;lung metastatic;Maximum Tolerated Dose;Melanocortin 1 Receptor;Melanoma;Melanoma Cell;Melanoma patient;Metastatic Melanoma;Modeling;Molecular Target;molecular targeted therapies;Mus;novel;Organ;originality;Patient Monitoring;patient response;Patients;Peptides;personalized diagnostics;personalized medicine;programmed cell death protein 1;Property;Radionuclide therapy;receptor;receptor binding;Regimen;Research;Research Design;Skin Cancer;success;targeted treatment;theranostics;Therapeutic;Treatment Efficacy;treatment strategy;tumor;United States;uptake;Xenograft procedure

PROJECT_TITLE: Combinations of Receptor-Targeted Alpha Radionuclide Therapy and Immune Checkpoint Inhibitors for Melanoma Treatment

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Neurosciences;Pain Research;Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation;Spinal Cord Injury;Telehealth;Traumatic Head and Spine Injury

ORG_CITY: HOUSTON

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative: The proposed research is relevant to public health because the identification of affordable and accessible adjuvant treatments for managing pain in people with SCI will result in improved quality of life and better pain management compared to ineffective pharmacological interventions with significant side effects.

PI_NAMEs: KORUPOLU, RADHA  (contact);RATCLIFF, CHELSEA GILTS

PROGRAM_OFFICER_NAME: CHIDEYA-CHIHOTA, SEKAI RUTENDO

PROJECT_TERMS: acceptability and feasibility;active control;addiction;Adherence;adherence rate;Adjuvant;Adjuvant Therapy;Affect;anti-depressive agents;anti-epileptic agents;Anxiety;Award;Categories;chronic pain;chronic pain management;Clinical;Clinical Trials;college;community advisory board;comparison intervention;Consent;Constipation;coping;cost;COVID-19 pandemic;Data;Data Collection;design;Diagnosis;Educational Intervention;efficacy evaluation;efficacy study;efficacy trial;Eligibility Determination;Exercise;experience;Feedback;follow up assessment;follow-up;Funding;Goals;Grant;handheld mobile device;health care availability;health related quality of life;Healthcare Systems;Home;Impaired cognition;improved;Individual;innovation;inter-institutional;International;Internet;Intervention;Life;Measures;Medicine;Meditation;Mental Depression;Mental Health;mindfulness;mindfulness meditation;mobile application;multidisciplinary;Nonpharmacologic Therapy;online delivery;Opioid;Outcome;Pain;Pain interference;Pain management;pain outcome;Pain quality;pain reduction;pain relief;pain self-management;Participant;Patient Outcomes Assessments;Persistent pain;Persons;Pharmaceutical Preparations;pharmacologic;Physical Medicine;physical symptom;Physiological;Pilot Projects;Population;post intervention;Prevalence;primary outcome;Procedures;Proliferating;Protocols documentation;Psyche structure;Public Health;Quality of life;Randomized;Recommendation;recruit;remote delivery;Remote management;Reporting;Research;Research Assistant;Research Personnel;response;retention rate;Risk;Running;satisfaction;secondary outcome;Sedation procedure;Self Care;side effect;Spinal cord injury;Spinal cord injury patients;Surveys;Telemedicine;Therapeutic;Time;tool;Training;Translating;United States Department of Veterans Affairs;Visit;Withdrawal;Work

PROJECT_TITLE: Feasibility of Mindfulness Meditation Training and Home Practice in Persons with Spinal Cord Injury: A Pilot Study


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Resident-to-resident aggression (RRA) is a prevalent issue in long-term care with severe health consequences to residents, many of whom suffer from Alzheimer's Disease and Related Dementias (ADRD) and are minority racial/ethnic backgrounds. We propose to comprehensively examine the role of race and ethnicity in RRA using already existing prospective prevalence data, in addition to collecting nursing home stakeholder input to improve understanding of the role of race/ethnicity in RRA to inform a novel staff education RRA intervention development. This proposal thus has the potential to reduce race/ethnicity-related RRA, strengthen workforce training by improving provider competency for resolving race and ethnicity-related aggression among residents, and benefit residents with ADRD from diverse racial/ethnic backgrounds who are at higher risk of RRA involvement due cognitive impairment related behavioral symptoms.

PI_NAMEs: CHANG, E-SHIEN  (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: acceptability and feasibility;Active Learning;Address;Administrator;Advocacy;Aggressive behavior;Alzheimer's disease related dementia;Automobile Driving;Award;Basic Science;Behavior Therapy;Behavioral Symptoms;career;career development;Caring;Certification;Characteristics;Cluster randomized trial;Cohort Studies;community setting;Competence;Conflict (Psychology);Data;Data Set;Dementia;design;Development;Discipline;Discipline of Nursing;Disinhibition;Education;Educational Intervention;efficacy evaluation;Elder Abuse;Elder abuse prevention;Equity;ethnic diversity;ethnic health disparity;ethnic minority;Ethnic Origin;evidence base;experience;feasibility testing;Feedback;Focus Groups;Funding;Goals;Health;health disparity;health equity;Health equity research;high risk;Impaired cognition;implementation science;improved;Individual;Injury;Intervention;intervention program;Knowledge;Lead;Leadership;Learning Module;Long-Term Care;maltreatment;Measurable;Mentors;Mentorship;Methods;mild cognitive impairment;Minority;Modeling;multilevel analysis;novel;Nursing Homes;Older Population;Pattern;pilot test;Play;Policy Making;Population;Positioning Attribute;Prevalence;prevent;Prevention;Prevention strategy;Productivity;programs;prospective;Prospective Studies;Provider;psychological distress;public health priorities;public health research;Race;racial diversity;racial health disparity;racial minority;racism;Research;Research Personnel;resilience factor;response;Risk;Role;Safety;Scientist;skills;social;social health determinants;Societies;Summary Reports;Surveys;Symptoms;System;Testing;therapy development;Time;Training;trend;United States National Institutes of Health;verbal;Violence;Work

PROJECT_TITLE: "Improving Health Equity in Long-Term Care Residents with Dementia: The Role of Race and Ethnicity in Resident-to-Resident Aggression"

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: Nashville

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Narrative: This project tests the hypothesis that small extracellular vesicles secreted in the breast cancer microenvironment drive tumor aggressiveness and metastasis. It is relevant to public health because it may identify key molecular determinants driving breast cancer outcome.

PI_NAMEs: PONIK, SUZANNE MARIE;WEAVER, ALISSA M (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: adhesion receptor;Adhesions;Adhesives;autocrine;Autocrine Communication;Automobile Driving;Binding;Biogenesis;Biological Assay;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Patient;breast cancer progression;cancer cell;cancer subtypes;Cell Adhesion Molecules;cell motility;Cell Survival;Cells;comparison control;conditioning;Data;Defect;Distant;ECM receptor;Epithelium;exosome;Extracellular Matrix;extracellular vesicles;Fibroblasts;Fibronectins;Grant;Growth;In Vitro;in vivo;Integrin Binding;Integrins;Invaded;Laminin;Ligands;Lung;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mediating;Microscopy;migration;Modeling;Molecular;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;novel;Outcome;Paracrine Communication;Primary Neoplasm;Process;Prognosis;Proteins;Proteomics;Public Health;Reporting;Role;Sampling;scaffold;Site;Small Cell Carcinoma;Speed;syndecan;Testing;Tissue Microarray;Tissues;Tube;tumor;tumor growth;tumor microenvironment;Western Blotting

PROJECT_TITLE: Exosome secretion in breast cancer progression

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Aphasia;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Prevention;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE This study will use novel analysis techniques to investigate biological processes in the brain that are related to disease progression in patients with the non-fluent/agrammatic variant of primary progressive aphasia. We will measure brain neuroinflammation using neuroimaging, as well as biomarkers of neuroinflammation and neurodegeneration from blood samples, and determine how these biological processes relate to clinical disease progression and structural and functional abnormalities in the brain. The study will improve our understanding of disease progression in these patients, provide new biomarkers of disease, and lead to better targeted future treatments.

PI_NAMEs: WHITWELL, JENNIFER LOUISE (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Address;Aphasia;Apraxia;Area;astrogliosis;Atrophic;Autopsy;Biological;Biological Markers;Biological Process;Biology;Blood specimen;blood-based biomarker;Brain;brain abnormalities;Broca's area;Chitinase;Clinical;Clinical Trials;Cognitive;comparison control;Data;Deposition;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Disease Progression;Functional Magnetic Resonance Imaging;Future;Generations;Glial Fibrillary Acidic Protein;Grant;improved;in vivo;Inflammation;inflammatory marker;Injury;Knowledge;Language;Ligand Binding;Ligands;Light;Magnetic Resonance Imaging;Measures;Mediating;Modeling;Motor;Motor Cortex;MRI Scans;Multimodal Imaging;multimodal modeling;Nerve Degeneration;Neurodegenerative Disorders;neurofilament;neuroimaging;neuroinflammation;Neurologic;novel;Participant;Pathologic Processes;Patients;Pattern;Plasma;Play;Positron-Emission Tomography;Primary Progressive Aphasia;Process Measure;prognosis biomarker;Prognostic Marker;Proteins;recruit;research study;Rest;Role;Severities;Severity of illness;Signal Transduction;Speech;Structure;tau aggregation;tau Proteins;Tauopathies;Techniques;Time;tractography;uptake;Variant;Visit;white matter;Work

PROJECT_TITLE: Longitudinal multi-modality imaging in non-fluent/agrammatic primary progressive aphasia

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Pediatric

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PUBLIC HEALTH RELEVANCE: Recent evidence suggests that the same event can engage different brain circuits at different ages with transitions between these circuits considered periods of vulnerability that can initiate a pathway to pathology. Yet, we have little understandin of how a child can switch between these circuits or why access to an early life circuit is lost. To address this gap, we propose to use a model system where two different circuits are evoked by the same event at two different ages, and a brief developmental period when both circuits co-exist and maternal presence controls which circuit is used.

PI_NAMEs: SULLIVAN, REGINA MARIE (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Adaptive Behaviors;Address;Adult;Age;Agonist;Amaze;Amygdaloid structure;analytical tool;antagonist;Anterior;Area;Attention deficit hyperactivity disorder;Avoidance Learning;Behavior;Behavioral;Biological Models;Brain;Brain region;Caregivers;Child;Child Behavior;cingulate cortex;Complex;conditioned fear;conditioning;Data;Dependence;Development;developmental disease;Dopamine;Electrophysiology (science);Equation;Event;Exhibits;flexibility;FOS gene;Fright;frontal lobe;Functional disorder;Functional Magnetic Resonance Imaging;Growth;Health;Human;Immediate-Early Genes;Immunohistochemistry;Individual;Infant;juvenile animal;Learning;learning ability;Lesion;Life;Measures;Mental Depression;Modeling;Mothers;Neonatal;neonate;neural;neural circuit;neurobehavioral;novel;novel strategies;Odors;Organism;Pain;Pathology;Pathway interactions;Pattern;preference;Prefrontal Cortex;Preparation;public health relevance;pup;Rattus;receptor;Research;response;Role;Shock;Signal Transduction;Source;Stimulus;Structure;System;Techniques;Testing;Translational Research;Translations;Ventral Tegmental Area;Weaning

PROJECT_TITLE: Maternal Control Over Developing Prefrontal Cortex and Transition in Independence

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Digestive Diseases;Neurosciences

ORG_CITY: CHARLESTOWN

ORG_NAME: SPAULDING REHABILITATION HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The primary aims of this single-blind, randomized, sham-controlled cross-over study are to 1) evaluate gastric function and brain response to gastric interoceptive signaling following calibrated meal ingestion in healthy adults; 2) investigate transcutaneous auricular vagus nerve stimulation (taVNS) modulation of gastric function and brain response to gastric interoceptive signaling in healthy adults. Using our fully non-invasive framework including gastric and brain MRI and taVNS, we aim to link the central gastric interoceptive circuitry to objective outcomes of gastric function.

PI_NAMEs: NAPADOW, VITALY ;SCLOCCO, ROBERTA  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEN G

PROJECT_TERMS: Adult;Amygdaloid structure;Animal Model;Anterior;Area;Brain;Brain imaging;brain magnetic resonance imaging;Brain region;Brain Stem;Breathing;Calibration;Cell Nucleus;Cells;cingulate cortex;Clinical;cohort;contrast enhanced;Cross-Over Studies;dorsal motor nucleus;Esophagus;Evaluation;experimental study;Feedback;Food;Four-dimensional;Functional Gastrointestinal Disorders;Functional Magnetic Resonance Imaging;gastrointestinal;Gastrointestinal Diseases;Gastrointestinal tract structure;Goals;gut-brain axis;Human;Hypothalamic structure;Image;improved;Individual;Ingestion;insight;Insula of Reil;Interoception;Intervention;kinematics;Lead;Link;Magnetic Resonance Imaging;Measures;Mechanoreceptors;mechanotransduction;Methods;Molecular;Muscle Tonus;Nerve;neural circuit;neuroimaging;neuroregulation;Nodose Ganglion;novel;Nucleus solitarius;Organism;Outcome;parabrachial nucleus;Pathway interactions;Peristalsis;Physiology;Pontine structure;Process;Proxy;Randomized;Rectum;Relaxation;Reporting;Research;response;Role;Signal Transduction;Single-Blind Study;Source;Spinal;Stomach;Techniques;Thalamic structure;tool;Upper digestive tract structure;vagus nerve stimulation;Vagus nerve structure;Visceral

PROJECT_TITLE: Non-invasive assessment and modulation of brain-gut interoception in humans

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE Genetic exchange between homologous chromosomes is essential to ensure that they segregate accurately in meiosis, the specialized cell division that gives rise to eggs and sperm. Errors in recombination can lead to an incorrect number of chromosomes, which is the most common cause of birth defects and miscarriage. However, the same type of exchange in other cells can lead to cancer. This proposal seeks to understand how exchange is promoted in cells undergoing meiosis but avoided in other tissues, in terms of both regulation and molecular mechanisms of recombination processes.

PI_NAMEs: SEKELSKY, JEFF J. (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Aneuploidy;Biochemistry;Biology;career;Cell division;Cell Proliferation;Cells;Cellular biology;Chromosome Segregation;Chromosomes;Congenital Abnormality;CRISPR gene drive;Dangerousness;Defect;design;DNA Damage;DNA Double Strand Break;Double Strand Break Repair;Drosophila genus;egg;experimental study;gene drive system;Genetic;Genetic Crossing Over;Genetic Recombination;Genomic Instability;Genomics;Germ Cells;Investigation;Laboratories;Malignant Neoplasms;mathematical model;Meiosis;Meiotic Recombination;Mitotic;Mitotic Recombination;model organism;Molecular;Outcome;Pattern;Pregnancy loss;Process;Regulation;repaired;Research;Scientist;segregation;sperm cell;Spontaneous abortion;Sterility;Time;Tissues;Training;Trisomy;tumorigenesis

PROJECT_TITLE: Mechanisms of meiotic and mitotic recombination

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Neurosciences;Nutrition;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Narrative Treatment options for Glioblastoma (GBM) – a deadly disease with median survival of ~15 months – have changed little over the past 50 years, but preclinical data suggest a ketogenic diet (KD) may have anti-GBM effects. Given many GBM patients attempt to adopt some version of KD despite the lack of high-quality data supporting its use, we recently completed a phase 1 KD trial for newly diagnosed GBM, wherein we achieved the primary aim of safety and feasibility and found an impressive median Overall Survival (OS) of 29.1 months, which is a 99% improvement vs. historic control from the phase 3 trial that established the current standard-of- care. We are now poised to conduct, for the first time, a well-powered multicenter randomized controlled phase 2 trial testing the efficacy of a KD plus standard-of-care vs. standard-of-care to improve OS in newly diagnosed GBM patients, along with correlative studies to uncover the potential mechanisms by which a KD may delay GBM progression and improve quality-of-life, providing key data which can inform clinical care.

PI_NAMEs: FREEDLAND, STEPHEN JAY;HU, JETHRO  (contact)

PROGRAM_OFFICER_NAME: XI, DAN

PROJECT_TERMS: Address;Adherence;Adopted;anti-cancer;anti-tumor immune response;arm;Bioenergetics;Biological Markers;Blood specimen;Brain Neoplasms;cancer therapy;Carbohydrates;Clinical;clinical care;clinical efficacy;clinical practice;Cognition;cognitive function;cognitive performance;Correlative Study;cost;Counseling;cytokine;Data;Diagnostic;Diet;diet and cancer;Disease;Early identification;efficacy testing;Environment;experience;Fatigue;Fatty acid glycerol esters;Feces;fitbit;Future;genome sequencing;Glioblastoma;Glucose;Glycolysis;Goals;Growth;gut bacteria;gut microbiota;Human;Immune;Immune response;immunoregulation;improved;improved outcome;indexing;Inflammasome;Inflammatory;inflammatory marker;Inflammatory Response;Insulin;Insulin Resistance;Insulin-Like Growth Factor Binding Protein 3;Insulin-Like Growth Factor I;Interleukin-1 beta;ketogenic diet;Ketones;Knowledge;Leisures;Malignant Neoplasms;Measures;Mediating;Metabolic;Metabolism;metabolomics;Modeling;Monitor;Moods;Newly Diagnosed;Outcome;Patient Care;Patient-Focused Outcomes;Patients;Peripheral;Personal Satisfaction;Persons;Persuasive Communication;Phase;phase 1 study;phase 2 study;phase II trial;phase III trial;Physical activity;Physical Function;Physiology;PIK3CG gene;pre-clinical;predicting response;Production;Prognosis;programmed cell death ligand 1;Progression-Free Survivals;prospective;Quality of life;Quality of Life Assessment;Questionnaires;radiological imaging;Randomized;Resistance;response;safety and feasibility;secondary endpoint;Seizures;Serum;Shapes;Signal Transduction;single cell analysis;Stains;standard care;standard of care;stool sample;T cell response;T-Lymphocyte;Testing;Therapeutic;Time;Tissue-Specific Gene Expression;Toxic effect;Trail Making Test;transcriptome sequencing;transcriptomics;Translational Research;translational study;treatment optimization;tumor;Tumor Immunity;tumor metabolism;Tumor Tissue;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;tumorigenesis;whole genome;Work

PROJECT_TITLE: A randomized controlled phase 2 study of the ketogenic diet for patients with newly diagnosed glioblastoma in combination with standard-of-care treatment


NIH_SPENDING_CATS: Natural Products

PHR: Project Narrative The reactions that are targeted in this study have the capacity to deliver functional group-rich compounds that will be immediately useful for preparation of a range of chiral small molecule building blocks. The proposal seeks to provide those in the biomedical community straightforward access to new families of molecules that will be useful for a range of applications.

PI_NAMEs: JOHNSON, JEFFREY S (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Address;analog;Biological;Catalysis;catalyst;Chemicals;Communities;Complex;Conversion disorder;Development;enantiomer;Evaluation;Family;functional group;Goals;Knowledge;Laboratories;Methods;Natural Products;next generation;Preparation;Productivity;programs;Reaction;Research Activity;small molecule;small molecule therapeutics;Sodium Chloride;Structure;Synthesis Chemistry

PROJECT_TITLE: Synthesis of Bioactive Small Molecule Building Blocks

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: ATLANTA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Increasing antibiotic resistance is a major problem that threatens to end the clinical usefulness of many antibiotics and fundamentally alter our ability to treat bacterial infections. This proposal will extend our studies of enzymes that chemically modify specific RNA molecules to alter antibiotic activity and will also establish a new paradigm for understanding how these modifications impact antibiotic-target interactions. Detailed understanding of mechanisms of resistance and antibiotic-target interactions are necessary prerequisites for the development of new strategies to extend the clinical life of current antibiotics or to create novel designer drugs to combat resistant bacteria.

PI_NAMEs: CONN, GRAEME L (contact);DUNHAM, CHRISTINE M

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: active method;Address;Affect;Aminoglycoside resistance;Aminoglycosides;analog;Antibiotic Resistance;Antibiotics;antimicrobial;Antimycobacterial Agents;Bacteria;Bacterial Antibiotic Resistance;Bacterial Infections;bacterial resistance;base;Binding;Biochemical;Biological Assay;Capromycin;Cessation of life;chemical synthesis;Chemicals;Clinical;clinically relevant;combat;Computer Models;crosslink;Cryoelectron Microscopy;design;Designer Drugs;Deuterium;Development;Docking;drug efficacy;Drug resistance;Drug resistance in tuberculosis;enzyme substrate complex;Enzymes;Essential Drugs;experimental analysis;experimental study;flexibility;Foundations;functional group;Future;Goals;Healthcare;human pathogen;Hydrogen;In Vitro;Infection;inhibitor;innovation;insight;Knowledge;Life;Measurement;Mediating;Medical;Methylation;Methyltransferase;Modernization;Modification;Molecular;Molecular Conformation;Molecular Mechanisms of Action;mycobacterial;Mycobacterium tuberculosis;novel;particle;Persons;Pharmaceutical Preparations;Population;Predisposition;Protein Dynamics;rational design;Resistance;Resistance development;resistance mechanism;Resolution;Ribosomal RNA;Ribosomes;RNA;RNA Binding;RNA methylation;RNA, Ribosomal, 16S;Role;Site;Structure;Substrate Specificity;Surface;Therapeutic;Work;X-Ray Crystallography

PROJECT_TITLE: RNA modification and antibiotic resistance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-U(02)M]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE Dementia due to Alzheimer’s disease and related dementias (ADRD) disproportionately impacts racial/ethnic minorities and the socioeconomically disadvantaged; groups more often exposed to neighborhood disadvantage. Prior research supports that neighborhood disadvantage is modifiable and interacts with biological processes to produce disease, yet little is known of its impact on ADRD. This project leverages data within 22 Alzheimer’s Disease Research Centers across the US to conduct the largest study of its kind on social determinants of health in the context of AD and to develop a novel collaborative infrastructure of contextual exposure for future social-biological phenotypic evaluation-- a potential pathway to new therapeutics directly responsive to the NIA mission.

PI_NAMEs: BENDLIN, BARBARA BRIGITTA;KIND, AMY J. (contact)

PROGRAM_OFFICER_NAME: ELLIOTT, CERISE

PROJECT_TERMS: Address;Age;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Animal Model;Area;Atlases;Autopsy;Back;Behavior;Biological;Biological Process;Biological Specimen Banks;Brain;burden of illness;California;Clinical;Code;Cognitive;cognitive change;cognitive function;Collaborations;comorbidity;Consent;Data;Dementia;deprivation;Development;Diagnosis;Disadvantaged;Disease;Disparity;Distal;dosage;Dose;Education;effective intervention;Employment;ethnic minority;Ethnic Origin;Evaluation;Exposure to;Foundations;Funding;Future;Geography;Goals;Health;Health behavior;Housing;Human;Impaired cognition;improved;Income;indexing;Individual;Individual Adjustment;Industry;Infrastructure;Interdisciplinary Study;Life Cycle Stages;Link;Magnetic Resonance Imaging;Mediating;Mediator;Methodology;Mission;mortality;National Institute on Aging;neighborhood association;neighborhood disadvantage;Neighborhoods;Nerve Degeneration;neuroimaging;neuropathology;neurophysiology;novel;novel therapeutic intervention;novel therapeutics;Outcome;Participant;Partner in relationship;Pathologic;Pathway interactions;Persons;Phenotype;Populations at Risk;Positron-Emission Tomography;Poverty;Prevalence;prospective;public database;Race;racial minority;randomized trial;Recording of previous events;Research;Research Design;Research Support;Risk;Risk Assessment;Risk Factors;Sampling;Science;secondary outcome;sex;social;social health determinants;socioeconomic disadvantage;socioeconomics;sociologist;Standardization;Surveys;tau Proteins;theories;therapy development;Time;Tissues;Universities;Wisconsin;Work

PROJECT_TITLE: The Neighborhoods Study: Contextual Disadvantage and Alzheimer’s Disease and Related Dementias (ADRD)


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Immunization;Neurodegenerative;Neurosciences

ORG_CITY: ANN ARBOR

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: The goal of this research is to improve the delivery of neuroprotective antibodies to the brain by generating bifunctional antibodies that target both a protein at the blood brain barrier and a target within the brain. This research will involve optimizing bifunctional antibodies to achieve high and sustained antibody levels in the brain, and then using them to prevent Alzheimer's disease-like pathology in animal models. The bifunctional antibodies and insights gained in this work are expected to accelerate the development of therapeutics for treating Alzheimer's disease and other neurodegenerative disorders.

PI_NAMEs: GREINEDER, COLIN FRED;TESSIER, PETER M (contact)

PROGRAM_OFFICER_NAME: GROTHAUS, PAUL G

PROJECT_TERMS: Acceleration;Address;Adult;Adverse effects;Affect;Affinity;Age;age effect;age related neurodegeneration;aged;Agonist;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease therapeutic;American;Amino Acid Transport System L;Amino Acids;Animal Model;antagonist;Antibodies;Avidity;Biological Products;Bispecific Antibodies;Blood - brain barrier anatomy;blood-brain barrier penetration;Brain;brain parenchyma;cerebrovascular;Characteristics;Clinic;Clinical;clinical efficacy;Cognitive deficits;Combined Modality Therapy;cross reactivity;Data;Dementia;Development;Disease;Dose;efficacy evaluation;efficacy outcomes;Endothelium;Enzyme-Linked Immunosorbent Assay;Epitopes;Functional disorder;Generations;Goals;Growth Factor;Hormones;human old age (65+);Immunoglobulin G;Impaired cognition;improved;Individual;Injections;insight;Knowledge;Ligands;Mediating;mouse model;Mus;Neurodegenerative Disorders;Neurons;neuroprotection;Neuroprotective Agents;novel therapeutics;Outcome;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Phosphorylation;pre-clinical;preservation;prevent;Property;Proteins;receptor;Research;Safety;Signaling Molecule;small molecule therapeutics;Specificity;Synapses;targeted treatment;tau Proteins;tau-1;Technology;Testing;TFRC gene;Therapeutic;therapeutic development;therapeutic protein;uptake;Viral;Viral Vector;Western Blotting;Work

PROJECT_TITLE: CD98hc Brain Shuttles for Delivering Off-the-shelf Neuroprotective Antibodies in Alzheimer's Disease


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Rehabilitation;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: Los Angeles

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE This research is relevant to public health because it will uncover new neurobiological influences on how people regain motor and sensory function after a stroke. Specifically, this study will examine the role of global brain health measures, which represent deterioration of systems across the whole brain, in stroke recovery by analyzing both: (a) a large existing database of neuroimaging and behavioral data on stroke patients and (b) new data that will be collected in the first 3 months following stroke, when the majority of stroke recovery is thought to occur. The project is relevant to the NIH’s mission because it will create important new knowledge on the relationships of global brain health to post-stroke brain injury, brain repair, and sensorimotor recovery, which can be used to identify novel therapeutic targets to improve stroke recovery.

PI_NAMEs: LIEW, SOOK-LEI  (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Accounting;Acute;acute stroke;Affect;Age;Alzheimer's Disease;American;Atrophic;Automobile Driving;Behavioral;Blood Vessels;Brain;brain health;Brain imaging;Brain Injuries;Brain Mapping;brain repair;chronic stroke;Corticospinal Tracts;Cross-Sectional Studies;Data;Data Collection;Data Set;Databases;Deterioration;diffusion anisotropy;Diffusion Magnetic Resonance Imaging;Distant;effective therapy;experience;Factor Analysis;Geography;Global Change;Health Care Costs;Image;improved;indexing;Individual;Infarction;Injury;innovation;Knowledge;Lesion;Link;Longitudinal Studies;Measures;Mission;Modeling;mortality;Motor;Motor Evoked Potentials;neural repair;Neurobiology;neuroimaging;Neuronal Plasticity;new therapeutic target;novel;Outcome;outcome prediction;Persons;Population;post stroke;Process;prospective;Public Health;Recovery;Research;research and development;Resources;Risk;Role;secondary analysis;Sensory;Severities;Site;Spatial Distribution;Stroke;stroke outcome;stroke patient;stroke recovery;Structure;System;Techniques;Testing;therapeutic development;therapeutic target;Transcranial magnetic stimulation;Traumatic Brain Injury;United States National Institutes of Health;Ventricular;White Matter Hyperintensity;Work;working group

PROJECT_TITLE: Effects of global brain health on sensorimotor recovery after stroke

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ORG_CITY: MINNEAPOLIS

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: OVERALL: NARRATIVE The Minnesota Population Center (MPC) provides critical research infrastructure to advance fundamental knowledge about human population dynamics and population health. MPC supports innovative scholarship and research infrastructure development in the areas of population health and health systems; spatial and environmental demography; reproductive health; work, family, and time; and structural racism and health inequities.

PI_NAMEs: OSYPUK, THERESA LOUISE (contact)

PROGRAM_OFFICER_NAME: CLARK, REBECCA L

PROJECT_TERMS: Area;career;cohort;college;Communication;Communities;Country;Data;data infrastructure;Demography;design;Development;Discipline;Environment;Faculty;Family;Fostering;Foundations;Funding;Goals;health inequalities;Health Policy;Health system;Human;Incubated;Influentials;infrastructure development;innovation;Institution;Interdisciplinary Study;International;Investments;Journals;Knowledge;marginalized population;Measures;member;Methodology;Minnesota;National Institute of Child Health and Human Development;next generation;Peer Review;Population;Population Dynamics;population health;Population Research;Principal Investigator;Process;Productivity;Public Health;Public Policy;Publications;Publishing;Reproductive Health;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;Scholarship;Schools;Scientist;Services;social media;Source;Structural Racism;success;Time;Training;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Minnesota Population Center


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Nutrition

ORG_CITY: DALLAS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Nonalcoholic steatohepatitis (NASH) has become a leading cause of liver-related morbidity and mortality. We recently discovered that macrophage TREM2, whose expression is positively and tightly associated with NASH progression, protects mice from NASH. In this study, we will comprehensively investigate how TREM2 expression is regulated during NASH progression, what TREM2 does in macrophages to prevent NASH development, and whether blocking TREM2 cleavage can inhibit NASH.

PI_NAMEs: LIANG, SHUANG  (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Acceleration;Amino Acid Substitution;Apoptotic;Automobile Driving;Back;Biological Process;Cells;Cessation of life;Chronic;chronic liver disease;chronic liver inflammation;Cirrhosis;combat;cytokine;Data;Defect;design;Development;dietary;Down-Regulation;Event;Exhibits;experimental study;Fatty Liver;feeding;Fibrosis;Foundations;Gatekeeping;Genetic;Goals;Hepatic;Hepatocyte;hepatocyte injury;High Fat Diet;in vivo;in vivo evaluation;Inflammation;Inflammatory;inorganic phosphate;insight;Interleukin-6;Knock-in;Knock-in Mouse;Knockout Mice;Kupffer Cells;Length;Licensing;Lipids;Liver;liver inflammation;liver injury;liver transplantation;Macrophage;Mediating;Messenger RNA;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Myelogenous;Myeloid Cells;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel therapeutic intervention;novel therapeutics;Obesity;overexpression;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pattern;Peptide Hydrolases;Phagocytes;Phagosomes;Phenotype;Play;Population;preservation;Prevalence;prevent;Primary carcinoma of the liver cells;Process;Production;Proteins;Resistance;Resolution;Role;Signal Pathway;Signal Transduction;simple steatosis;Site;Surface;Testing;therapy development;TNF gene;transcriptome sequencing;transcriptomics;TREM2 gene;Up-Regulation;western diet

PROJECT_TITLE: Deciphering the role of TREM2 in Non-Alcoholic Steatohepatitis

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


PROJECT_TITLE: Minnesota Population Center Administrative Core


ORG_CITY: HERSHEY

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE In the current grant proposal, we will study how endogenous opioids (called endomorphins) and clinically employed opiates (such as fentanyl, remifentanil) regulate the entry of Na+ ions through acid sensing ion channels (ASIC) in rat sensory neurons. We will also investigate the ability of endomorphins to enhance blood pressure increases mediated by lactic acid and contracting muscle. We will employ rats with “freely perfused” femoral arteries and those that have had their femoral artery “ligated”—a model of peripheral artery disease.

PI_NAMEs: RUIZ-VELASCO, VICTOR  (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Acidosis;Acids;Acute;Address;Affect;Afferent Neurons;Affinity;Analgesics;Applications Grants;Arteries;ASIC channel;Atherosclerosis;Attention;Attenuated;attenuation;Biophysics;Blood Pressure;blood pressure elevation;Cardiac;Chemosensitization;Chest Pain;Chronic;claudication;Clinical;Contracts;Coronary Arteriosclerosis;Data;disease model;Drops;endogenous opioids;endomorphin 1;Environment;Exercise;experimental study;femoral artery;Fentanyl;Fibroblasts;Goals;Health;Heart Rate;Hyperalgesia;In Vitro;in vivo;Inflammation;Inflammatory;Intermittent Claudication;interstitial;ion channel blocker;Ions;Ischemia;Knock-out;L Cells;Lactic acid;Ligation;limb ischemia;Mechanoreceptors;Mediating;Metabolic;Modeling;mu opioid receptors;Muscle;Muscle Contraction;Muscle Fibers;Naloxone;Neurons;novel;Opioid;Opioid agonist;Opioid Peptide;Oxycodone;Pain;Pain in lower limb;Patients;Perception;Perfusion;Peripheral arterial disease;pharmacologic;Phase;Physiology;Play;prescription opioid;pressure;Production;Protein Isoforms;Rattus;Receptor Activation;Reflex action;remifentanil;Reporting;Resistance;response;Rest;Role;Sensory;Site;skeletal;Spinal Ganglia;Testing;Text;Thinness;Tissues;Toxin;Transfection;ventilation;voltage;Walking

PROJECT_TITLE: Opioid-induced potentiation of the exercise pressor reflex via acid-sensing ion channels (ASIC3) in health and simulated peripheral artery disease

STUDY_SECTION: HM

STUDY_SECTION_NAME: Hypertension and Microcirculation Study Section[HM]


ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Neuronal miscommunication, neuronal death, and abnormal depositions of proteins forming amyloid plaques and neurofibrillary tangles are the basic pathological hallmarks of Alzheimer's disease (AD), the most common form of dementia currently affecting more than six million Americans. The amyloid precursor protein (APP) is the precursor of the beta amyloid peptide (Aβ), the basic component of the amyloid plaques, but it is also involved in the regulation of neuronal communication and neuronal death. The proposed research program will enable us to investigate the molecular architecture of APP and related proteins using advanced structural biology techniques, and open the way towards understanding how the molecular architecture of the protein enables its physiological functions and how it may permit dysregulation of these functions in AD.

PI_NAMEs: PETROU, VASILEIOS I (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: abeta accumulation;Adult;Affect;Alzheimer's Disease;American;Amyloid;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Architecture;Behavior;beta secretase;Biochemical;Biological;Biological Process;Birth;Brain;C-terminal;Cell surface;cerebral atrophy;Communication;Complement;Cryoelectron Microscopy;cryogenics;Dementia;density;Deposition;Detergents;Disease;Drug Design;early onset;Early Onset Familial Alzheimer's Disease;Elements;Exhibits;experience;extracellular;familial Alzheimer disease;Family member;flexibility;Functional disorder;Future;gamma secretase;Gene Family;Gene Proteins;Goals;Homeostasis;Individual;Inherited;Intracellular Transport;Investigation;Knock-out;Learning;Length;Link;Location;Maintenance;Mammalian Cell;member;Membrane;Membrane Glycoproteins;Membrane Proteins;Methods;Microscope;Molecular;Molecular Sieve Chromatography;Mutation;N-Methyl-D-Aspartate Receptors;Nerve Degeneration;Nervous System;Neurites;Neurodegenerative Disorders;Neurofibrillary Tangles;neuron development;neuron loss;Neurons;neuropsychiatric disorder;neurotransmitter release;Nicotinic Receptors;Orthologous Gene;particle;Pathogenesis;Pathologic;Pathway interactions;Pattern;Peptides;Performance;Physiological;Play;Positioning Attribute;postsynaptic;Preparation;presynaptic;prevent;Procedures;Process;Program Description;programs;Proliferating;Property;Protein Biochemistry;protein complex;Protein Family;Proteins;receptor;reconstitution;Recycling;Regulation;Reporting;Research;Resolution;Resources;Role;Sampling;screening;secretase;Senile Plaques;Shapes;Signal Transduction;structural biology;Structure;Synapses;synaptic function;Synaptic plasticity;Synaptic Vesicles;synaptogenesis;System;Techniques;thermostability;Vertebral column;X-Ray Crystallography

PROJECT_TITLE: Structural characterization of APP family proteins


NIH_SPENDING_CATS: Clinical Research

PI_NAMEs: KAMP DUSH, CLAIRE M (contact)

PROJECT_TERMS: Address;cohort;Collaborations;Collection;Country;COVID-19;Data;Data Collection;Demography;design;Development;Ensure;Environment;Event;experience;Funding;Future;Goals;Grant;high reward;high risk;Hour;Individual;innovation;Institution;Interdisciplinary Study;Investments;Journals;Leadership;Literature;live stream;member;Mentors;Mentorship;Minnesota;National Institute of Child Health and Human Development;next generation;novel;online resource;Outcome;Persons;pilot test;Population;Population Dynamics;programs;Public Health;Publications;Race;Research;research and development;Research Assistant;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;response;scale up;Scholars Program;Services;success;Time;Underrepresented Populations;Universities;Writing

PROJECT_TITLE: Minnesota Population Center Development Core


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Infectious Diseases;Microbiome;Pediatric;Women's Health Research

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative The transfer of microbes from mother to infant at birth is widely recognized as a critical life event that impacts life-long health for the infant. At present, factors that promote an optimal transfer of microbes to the infant are not well-defined, and medical interventions that perturb microbial transfer, such as maternal antibiotics, put the infant at increased risk of adverse health outcomes. This proposal will investigate the influence of human breastmilk components produced during pregnancy in shaping the mother’s vaginal microbes and vaginal immune responses to promote transfer of beneficial microbes to the infant.

PI_NAMEs: PATRAS, KATY  (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: 3-Dimensional;Acceleration;adverse pregnancy outcome;Amniotic Fluid;Animal Model;Animals;Antibiotics;antimicrobial;Area;Bacteria;bacterial community;bacterial fitness;Bacteroides;beneficial microorganism;Biological;Biology;Birth;Breast Feeding;Cells;Clinical Research;Communicable Diseases;Communities;Complex;Development;Disease;dysbiosis;Environment;Enzymes;Epithelial Cells;Epithelium;Event;experience;fetal;Foundations;gastrointestinal epithelium;genetic variant;genome analysis;Germ-Free;Gnotobiotic;Growth;gut microbiota;Hand;Health;host microbiome;Human;Human Activities;Human Biology;Human Microbiome;human microbiota;Human Milk;human milk oligosaccharides;Immune;Immune response;Immune System Diseases;Immunity;immunoregulation;improved;In Vitro;in vivo;Infant;Infant Development;Infant Health;Inflammation;innovation;insight;Institution;Intervention;intrapartum;Knowledge;Lactation;Life;Link;Literature;maternal serum;Medical;Metabolic Diseases;Metabolism;Microbe;microbial;microbial community;microbiome;microbiome signature;microbiota;microbiota composition;model development;Modeling;Mothers;mouse model;Mucous Membrane;Mus;Neonatal;novel;Oligosaccharides;Organism;Organoids;Outcome;pathobiont;pathogen;Pathogenesis;Pathway interactions;Plasma;Polysaccharides;prebiotics;Pregnancy;Premature Birth;prevent;Process;Production;Publications;reproductive tract;Research;response;Risk;Role;Sampling;Shapes;Testing;Therapeutic;tissue culture;Urine;Vagina;vaginal microbiome;vaginal microbiota;vaginal mucosa;Work

PROJECT_TITLE: Evaluating the impact of human milk oligosaccharides on the vaginal microenvironment


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Immunotherapy;Lung;Lung Cancer;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project narrative Brain tumor is the leading cause of death by cancer in the pediatric population; thus there is a great need for novel therapies. Radiation is an important part of therapy for many high-grade tumors including medulloblastoma, the most common malignant pediatric brain tumor, but it is rarely curative and comes with significant side effects. This project aims to identify reversible causes of immune suppression in medulloblastomas treated with radiation so that we can leverage the benefits of immunotherapy to achieve long-term remission for patients with treatment-resistant tumors.

PI_NAMEs: DANG, MAI T (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Ablation;adaptive immune response;adaptive immunity;Adult;Affect;anti-tumor immune response;Antigen Presentation;Antigen-Presenting Cells;Antigens;antitumor effect;Area;arm;Biological Assay;Brain;Brain Glioblastoma;Brain Neoplasms;cancer stem cell;career;Cause of Death;CD8-Positive T-Lymphocytes;cell killing;Cell Physiology;Cell Survival;Cells;Cellular Immunity;chemotherapy;Child;Childhood;Childhood Brain Neoplasm;Childhood Malignant Brain Tumor;Clinical;clinical training;Coupled;cytotoxic;Cytotoxic T-Lymphocytes;Data;Dendritic Cells;Development;Disease remission;draining lymph node;Fellowship;Functional disorder;Genetic;Genetic Transcription;Genetically Engineered Mouse;Goals;Head;Heterogeneity;Immune;immune checkpoint blockade;Immune response;Immune system;Immunity;Immunology;Immunosuppression;Immunotherapy;Impairment;improved;improved outcome;Infiltration;Institution;Intervention;Investigation;Knowledge;Laboratories;Macrophage;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Mediating;Medulloblastoma;Melanoma;Mentors;Mentorship;Microglia;monocyte;Morbidity - disease rate;Mus;Myeloid Cells;Myeloid-derived suppressor cells;Natural Immunity;neoplastic cell;Nervous System Disorder;neuro-oncology;Neurology;Neurosciences;neutrophil;Neutrophil Infiltration;new therapeutic target;Non-Small-Cell Lung Carcinoma;novel;novel therapeutics;Oncology;Operative Surgical Procedures;Patients;Pediatric Hospitals;Pediatric Neurology;pediatric patients;Pharmaceutical Preparations;Phenotype;Philadelphia;Physicians;Play;Population;Positioning Attribute;professor;Radiation;radiation effect;Radiation therapy;recruit;Recurrence;Regulation;Research;Resistance;response;Role;Scientist;Seasons;side effect;single cell analysis;Site;skill acquisition;T cell response;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;tenure track;Testing;Therapeutic Intervention;tool;Training;Training Programs;transcriptomics;Treatment Efficacy;treatment response;treatment strategy;tumor;Tumor Immunity;tumor immunology;tumor microenvironment;tumor-immune system interactions;Universities;Washington;Work

PROJECT_TITLE: Contribution of myeloid cells to the anti-tumor adaptive immune response after radiation in a pediatric brain tumor

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Data Science;Genetic Testing;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: New York

ORG_NAME: ISABL INC.

PHR: Project Narrative Isabl GxT is a comprehensive sequencing diagnostic approach for pediatric patients and others with rare cancers, who rarely benefit from gene panel based testing. The goal of this SBIR proposal is to make precision medicine more inclusive and a possibility for every cancer patient.

PI_NAMEs: MEDINA, JUAN SANTIAGO (contact)

PROGRAM_OFFICER_NAME: LOU, XING-JIAN

PROJECT_TERMS: Academic Medical Centers;Address;algorithm development;Authorization documentation;Bioinformatics;Biological Assay;Biological Markers;biomarker discovery;biomarker driven;Breakthrough device;cancer diagnosis;cancer genome;Cancer Patient;Caring;Clinical;Clinical Research;clinically actionable;clinically relevant;Cloud Computing;commercial application;Commercial grade;companion diagnostics;complex data;cost;cost effective;Data;data integration;data modalities;Data Science;Data Set;design;detection limit;Diagnosis;Diagnostic;diagnostic development;diagnostic strategy;Diagnostic tests;DNA;empowerment;FDA approved;Formalin;Fresh Tissue;gene panel;Genetic;Genetic Markers;Genome;genome sequencing;Germ Lines;Goals;Grant;improved outcome;Infrastructure;Knowledge;Laboratories;large scale data;Malignant Childhood Neoplasm;Malignant Neoplasms;Marketing;Memorial Sloan-Kettering Cancer Center;mortality;multimodality;Mutation;novel marker;Oncology;Outcome;Outcome Study;Paraffin Embedding;Patients;pediatric patients;Phase;phase 2 study;Physicians;Positioning Attribute;precision medicine;Process;prospective;rare cancer;Reporting;Reproducibility;Research;research and development;research study;RNA;sample fixation;Sampling;Signal Transduction;Small Business Innovation Research Grant;technological innovation;Testing;Therapeutic;Training;transcriptome;transcriptome sequencing;treatment planning;tumor;tumor heterogeneity;validation studies;Variant;whole genome

PROJECT_TITLE: Isabl GxT: A clinically actionable whole genome and transcriptome precision medicine platform

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-V(13)B]


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: FITCH, CATHERINE A (contact)

PROJECT_TERMS: archive data;Communities;complex data;computer infrastructure;Computer software;Consultations;cost;cost effective;Data;data access;data archive;data centers;data dissemination;data format;data infrastructure;data integration;data preservation;Data Science;Data Scientist;Data Sources;data visualization;design;Development;digital object identifier;Emerging Technologies;Environment;experience;Facility Accesses;Floods;Funding;Goals;Health Service Area;High Performance Computing;Imagery;innovation;Institution;Investments;Life Cycle Stages;Machine Learning;Maintenance;Maps;member;Metadata;Methodology;Methods;Minnesota;Modeling;National Institute of Child Health and Human Development;next generation;operation;Pilot Projects;Population;Population Dynamics;Population Sciences;preservation;Process;Productivity;Provider;remote sensing;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Risk;Scanning;Science;Scientist;Secure;Services;software development;Software Engineering;Source;Specialist;Structure;Talents;Technical Expertise;Techniques;Technology;Time;tool;Training;Visualization;Work

PROJECT_TITLE: Minnesota Population Center Science and Technical Core


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE The Stanford K12 Clinician-Scientist Career Development Program will offer junior clinician investigators an individually tailored program with research mentoring, didactic education, and formal career development programming to bridge their transition to academic independence. The program's ultimate goal is to develop diverse, highly trained, creative and productive independent investigators who are able to achieve their career goals in ophthalmology and vision research.

PI_NAMEs: GOLDBERG, JEFFREY L (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Appointment;Basic Science;career;career development;Clinical;Clinical Research;clinically relevant;Communities;design;Development Plans;Educational Curriculum;Ethics;Exposure to;Eye;Faculty;Fellowship;Funding;Future;Goals;Infrastructure;Institution;interest;investigator training;K-Series Research Career Programs;Leadership;Measures;Mentored Clinical Scientist Development Program;Mentors;Mission;Ophthalmology;Outcome;Paper;peer coaching;Physicians;Postdoctoral Fellow;Productivity;Program Development;programs;recruit;Research;research faculty;Residencies;Resources;responsible research conduct;Role;Scientist;skills;Solid;statistics;success;supportive environment;System;Training;Training Programs;Translational Research;Underrepresented Minority;Universities;Vision;Vision research;Visual Fields;Woman;Writing


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Hearing Loss;Neurodegenerative;Neurosciences

ORG_CITY: AMHERST

ORG_DEPT: PSYCHOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative These experiments will address a significant gap in what we know about the causal link between hearing loss and Alzheimer’s disease by using mouse models with specific brain pathologies. Most studies on the effects of age, sex, and noise using these models test them with physiological and reflexive techniques, which do not accurately reflect how sounds are perceived in an awake, behaving state akin to people out and about in the world. This study aims to characterize the relationship between behavioral and physiological measures of hearing in quiet and noisy environments to learn more about the relationship between hearing loss and Alzheimer’s Disease.

PI_NAMEs: DENT, MICHEAL L (contact);LAUER, AMANDA M.

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: 3xTg-AD mouse;Acceleration;Active Listening;Affect;Age;age effect;Aging;aging process;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;Anesthesia procedures;Animal Model;Animals;APP-PS1;Audiology;Auditory;Auditory Brainstem Responses;Auditory Evoked Potentials;auditory processing;Auditory system;awake;base;Behavior;behavior measurement;Behavioral;Biological Assay;Brain Pathology;Brain Stem;Chronic;Clinical Research;Cochlea;cognitive function;Communication;Compensation;effectiveness testing;Environment;Epidemiology;epidemiology study;Evoked Potentials;experience;experimental study;Exposure to;Female;Functional disorder;Goals;Hair Cells;Health;healthy aging;Hearing;hearing impairment;hearing measurement;hearing screening;Hearing Tests;Human;Impairment;improved;Laboratories;Learning;life span;Link;male;Measurement;Measures;Mediating;Methods;Modeling;mouse model;Mouse Strains;Mus;Mutation;Nature;Neurofibrillary Tangles;neuropathology;Noise;normal aging;Operant Conditioning;Organism;Pathologic;Pathology;Patients;Performance;Peripheral;Persons;Phenotype;Physiological;Positive Reinforcements;Process;Psychoacoustics;Reporting;Research;Research Personnel;Response Latencies;Role;selective attention;Severities;sex;sound;Stimulus;Structure;Techniques;Testing;Time;Training

PROJECT_TITLE: Behavioral and physiological measurements of hearing in mouse models of Alzheimer's Disease

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Chronic Pain;Infectious Diseases;Pain Research;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Wound Healing and Care

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative Nearly every minute, someone in the United States sustains a burn injury serious enough to require treatment (~500,000 a year). Burn dressing removal is reportedly the time of most pain (after the burn itself) and opioids are the main treatment for such pain. This proposal describes the synthesis, characterization, and evaluation (in vitro, in vivo, and preclinical) of the first supramolecular hybrid hydrogel burn dressing that is on-demand dissoluble -for easy trauma-free removal from burn wound-, antimicrobial, and self-healable.

PI_NAMEs: ASATEKIN, AYSE ;USTA, OSMAN BERK (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Acceleration;Acute;Adamantane;Adoption;Adult;Anesthesia procedures;Animal Model;Animals;Antibiotics;antimicrobial;aqueous;Area;Bacterial Infections;Biocompatible Materials;biomaterial compatibility;Burn injury;burn wound;Caring;Cells;Cessation of life;Chemicals;Chemistry;Child;clay;Clinic;Clinical;clinically relevant;copolymer;cost;Critical Care;crosslink;cytokine;Data;Debridement;design;Development;disability;Economics;Electric Burns;Electrostatics;Emergency department visit;Emotional;Endothelial Cells;Epithelium;Evaluation;Excision;experience;experimental study;Exposure to;Face;falls;Family;Family suidae;Fibroblasts;Fire - disasters;Foreign-Body Reaction;Generations;Goals;Gram-Negative Bacteria;healing;Histology;Hour;Human;Hybrids;Hydrogel Bandage;Hydrogels;Immune;Immune Tolerance;Impaired healing;improved;In Vitro;in vitro Model;in vivo;in vivo evaluation;Inbred BALB C Mice;Infection;infection management;Infection prevention;Inflammatory;Inflammatory Response;Injury;Intensive Care Units;Interleukin-6;keratinocyte;Kinetics;Length of Stay;Life;Lymphocyte;Macrophage;mechanical properties;Mechanics;Methods;Mission;Modeling;Multiple Organ Failure;Mus;nanosheet;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Natural regeneration;novel;open wound;Operative Surgical Procedures;Opioid;Pain;Pain Free;pain reduction;Patient Care;Patients;pediatric patients;Performance;Persons;physical property;polyacrylate;pre-clinical;Predisposition;Procedures;Process;Property;psychologic;rational design;Regenerative Medicine;Reporting;Reproducibility;response;Risk;second degree burn;Sepsis;severe burns;Silver;Skin;skin wound;Sodium;Sterile coverings;Strategic Planning;Sulfadiazine;Surface;Survivors;Swelling;Testing;Time;tissue repair;Tissues;TNF gene;Toxic effect;Trauma;United States;Water;wound;wound healing;Wound Infection;Wound models

PROJECT_TITLE: On Demand Dissoluble Supramolecular Hydrogels: Towards Pain Free Burn Dressings

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Public Health Relevance: The microbes living on/in the human body, known as “the human microbiota”, metabolize various dietary nutrients, impact host metabolism, and are essential for human health. This proposal aims to investigate the molecular mechanisms behind microbiota-Type 2 diabetes (T2D) association and provides mechanistic insights of some microbial pathways involved in mediating host amino acid and glucose homeostasis. It will also pave the way for a systematic regulation of these health- related microbial pathways in the human gut using synthetic biology and microbial genetics to treat age-related disease like T2D.

PI_NAMEs: GUO, CHUN-JUN  (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Affect;Age;age related;age-related disease;amino acid metabolism;Amino Acid Metabolism Pathway;Amino Acids;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;bacterial genetics;Bioinformatics;Biological;Biological Assay;Biological Availability;Biology;blood glucose regulation;Cells;Clinical;Code;Collection;Communities;Complex;Consumption;Data;Diabetic mouse;Diet;dietary;Disease;Economic Burden;Engineering;Enterochromaffin Cells;Environmental Risk Factor;Epigenetic Process;Etiology;Fermentation;Functional disorder;Gene Modified;gene synthesis;Genes;Genetic;genetic manipulation;Genomics;Germ-Free;Glucose;glucose metabolism;glucose tolerance;Gnotobiotic;gut bacteria;gut microbes;gut microbiome;gut microbiota;Health;Homeostasis;Human;Human body;human microbiota;In Vitro;in vivo;inhibitor;insight;Intestines;Investigation;Knockout Mice;Kynurenine;Learning;longitudinal dataset;Mediating;member;Metabolic;Metabolic Diseases;Metabolic Pathway;metabolic phenotype;Metabolism;metabolomics;Microbe;microbial;microbial community;Microbial Genetics;microbiome;microbiota;microbiota composition;Molecular;Motivation;mouse model;multiple omics;Mus;mutant;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutic intervention;Nutrient;pan-genome;Pathway interactions;Patients;Peripheral;Phylogenetic Analysis;Play;Population;Prevalence;prevent;Public Health;public health relevance;Publishing;Receptor Signaling;Regulation;Role;Sampling;Serotonin;Severity of illness;Signal Pathway;Signal Transduction;Site;synthetic biology;System;Testing;Therapeutic;Tissues;Tryptophan;Work

PROJECT_TITLE: Molecular mechanisms behind microbiota regulation of host amino acid and glucose homeostasis

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Gene Therapy;Genetics;Immunotherapy;Lung;Lung Cancer

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA AGRICULTURAL AND MECHANICAL UNIV

ORG_STATE: FL

PHR: Project Narrative Natural Killer derived EVs ( NKEVs) carrying LMNB2 and PDL1 micro RNA will deliver their payload to Osimertinib resistant NSCLC and will be able to overcome resistance by using in combination with carboplatin with minimal side effects.

PI_NAMEs: SACHDEVA, MANDIP SINGH (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: anti-cancer;anti-cancer treatment;Antineoplastic Agents;Biological Assay;Bioreactors;Carboplatin;cell killing;Cells;Clinical Research;comparison control;cytotoxicity;Data;Dose;Down-Regulation;Drug Kinetics;Electroporation;Embryo;Encapsulated;Engineering;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Evaluation;exosome;Exposure to;extracellular vesicles;Fibroblasts;Formulation;Future;Gene Expression;Goals;heme oxygenase-1;Histological Techniques;Human;In Vitro;in vivo;Inbred BALB C Mice;Induction of Apoptosis;Interleukin-15;Intravenous;Kidney;kidney cell;Laboratories;lamin B2;Lung;Malignant neoplasm of lung;Malignant Neoplasms;manufacture;MAP Kinase Gene;Mesenchymal Stem Cells;microRNA delivery;MicroRNAs;Molecular;Monoclonal Antibodies;Mus;Mutate;Mutation;Natural Killer Cells;NF-kappa B;NOD/SCID mouse;Non-Small-Cell Lung Carcinoma;Outcome;p38 Mitogen Activated Protein Kinase;particle;patient derived xenograft model;Patients;Pharmacodynamics;Phase;phase 1 study;pre-clinical;Prognosis;programmed cell death ligand 1;programmed cell death protein 1;protein expression;Proteins;Proteomics;Research Personnel;Resistance;Resistance development;Reverse Transcriptase Polymerase Chain Reaction;Role;side effect;Study models;success;Techniques;Testing;Therapeutic;Toxic effect;Toxicology;transcriptome sequencing;tumor;Tumor Burden;Tyrosine Kinase Inhibitor;uptake;Vimentin;virtual;Western Blotting;Work;Xenograft procedure

PROJECT_TITLE: Exosomal Based micro RNA delivery for Resistant Lung Cancer


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

PHR: Project Narrative Due to relentlessly evolving drug resistance, a continual pipeline of new drug discovery is required to combat mortality caused by the malaria parasite. We have identified three new chemical series based on phenotypic screening and will conduct a medicinal chemistry and target identification program to determine if they have the potential to be developed for the treatment of malaria. Our multidisciplinary team has extensive experience working together and a successful track record in identifying drug candidates.

PI_NAMEs: PHILLIPS, MARGARET A. (contact);READY, JOSEPH M

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: absorption;acquired drug resistance;ADME Study;African;Ames Assay;Amides;analog;Anti-malarials;Antiparasitic Agents;azetidine;Biochemical;Biological;Biological Assay;Biology;Blood;Cell Line;Cells;Cessation of life;Chemicals;Chemistry;Chemoprevention;Child;Clinical;clinical candidate;clinical development;combat;Communicable Diseases;comparative efficacy;crosslink;Data;Development;Disease;Dose;drug candidate;drug discovery;Drug Kinetics;Drug resistance;drug-sensitive;Erythrocytes;Evaluation;Excretory function;experience;Genetic;genome sequencing;Goals;Half-Life;HepG2;high throughput screening;Human;Human Cell Line;human disease;In Vitro;in vivo;Insecticides;insight;Ion Channel;Kinetics;Lead;lead optimization;Life Cycle Stages;Liver;Malaria;Mammalian Cell;Mass Spectrum Analysis;Measures;Medicine;Metabolic;Metabolism;Modeling;Molecular Target;mortality;mouse model;multidisciplinary;Mus;novel;novel therapeutics;Parasite resistance;Parasites;Parents;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phenotype;piperidine;Plasmodium;Plasmodium falciparum;Plasmodium vivax;Population;Positioning Attribute;pre-clinical;preclinical development;pressure;Process;programs;Property;Proteomics;Protocols documentation;Publishing;Rattus;Recrudescences;Resistance;Risk;Safety;safety assessment;scaffold;SCID Mice;screening;Series;small molecule libraries;Solubility;Structure;Testing;Tetrazoles;Time;transmission blocking;Vaccines;Validation;whole genome;Work

PROJECT_TITLE: Optimization of novel phenotypic screening hits for treatment of Malaria

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

PHR: PROJECT NARRATIVE This Research Training in Endocrinology and Metabolism will provide outstanding young physician- scientists and PhD scientists with the resources, skills, knowledge and mentorship they need to launch careers in metabolic research. Providing rigorous, personalized instruction to our amazing trainees will give them a foundation to become successful scientists and leaders in the fields of diabetes, obesity, islet regeneration, thyroid biology and molecular metabolism.

PI_NAMEs: ALONSO, LAURA C (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Endocrinology;Research Training

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Lung;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE This project aims to understand how increased gut permeability and translocation of fungal products from the gut impacts lung function, respiratory symptoms, and disease progression in patients with chronic obstructive pulmonary disease (COPD). This project will also explore if the fungal cell wall product, 1,3 beta-d-glucan, has direct pathogenic effects on the lung and can be targeted as a novel therapy for COPD.

PI_NAMEs: BON, JESSICA  (contact);MORRIS, ALISON

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: absorption;Acute;Air;Antiinflammatory Effect;Apical;Attenuated;Bacteria;Bacterial Translocation;Binding;bronchial epithelium;CCL2 gene;CCL20 gene;Cell Wall;Cells;Cellular Structures;chest computed tomography;Chronic Obstructive Pulmonary Disease;cigarette smoke;Circulation;Clinical;Clinical Trials;cohort;CXCL10 gene;CXCL5 gene;cytokine;Data;dectin 1;Dendritic Cells;Disease;Disease Marker;Disease Outcome;Disease Progression;EphA2 Receptor;Epithelial Cells;Epithelium;Exercise;experimental study;Exposure to;exposure to cigarette smoke;follow-up;former smoker;Foundations;Frequencies;functional decline;Fungal Components;Future;gastrointestinal epithelium;gut-lung axis;Human;Hypoxia;IL8 gene;Immune;immune activation;Immune response;Immunoassay;Impairment;improved;In Vitro;indexing;Inflammation;Inflammation Mediators;Inflammatory;insight;Interleukin-6;Intestinal Mucosa;Intestinal permeability;Intestines;knock-down;Lactulose;laminaran;Liquid substance;Lung;lung injury;Macrophage;Macrophage Activation;Mannitol;Measures;Mediating;Mediation;Mediator;Metformin;Microbe;microbial;microbial products;Molecular;Movement;mRNA Expression;Mycoses;novel strategies;novel therapeutic intervention;novel therapeutics;Organism;Outcome;pathogen;Pathogenesis;Pathogenicity;Patients;Pattern;Pattern recognition receptor;Peripheral;Physical activity;Play;polyglucosan;Polysaccharides;prospective;Protein Secretion;Proteins;Pulmonary Emphysema;pulmonary function;pulmonary function decline;respiratory;respiratory morbidity;Respiratory Signs and Symptoms;Rest;Reverse Transcriptase Polymerase Chain Reaction;Risk Factors;Role;Severity of illness;Small Interfering RNA;small molecule inhibitor;Smoker;Smoking;sugar;Symptoms;targeted treatment;Testing;Tissues;TNF gene;Validation;Western Blotting

PROJECT_TITLE: Fungal Translocation in Chronic Obstructive Pulmonary Disease

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]