ORG_CITY: NEW YORK

PHR: PROJECT NARRATIVE The effectiveness of the widely prescribed drug, levodopa, in treating motor impairment in Parkinson’s disease declines over time, in part due to a progressive shortening in the time for which each dose of levodopa is effective. We recently found that repeated optogenetic stimulation of a specific neuron type in the external globus pallidus – the parvalbumin-expressing neurons – led to long-term rescue of locomotion deficit in parkinsonian mice, which recapitulates aspects of levodopa’s long-term rescue (its “long-duration response”). This project will examine the neural circuitry that underlies this beneficial effect of external globus pallidus stimulation; its elucidation will advance our knowledge of both therapeutic utility and potential side effects of globus pallidus deep brain stimulation for Parkinson’s disease.

PI_NAMEs: KANG, UN JUNG (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Accounting;Acute;Animal Model;Brain;Calcium;Data;Deep Brain Stimulation;Disabling;Discrimination;Discrimination Learning;dopaminergic neuron;Dose;Drug Compounding;Drug Delivery Systems;Drug Prescriptions;Effectiveness;Environment;experience;experimental study;Fiber;follow-up;Future;Genetic;Globus Pallidus;Hour;Impairment;improved;Knowledge;Learning;Levodopa;Locomotion;Mediating;Methods;Motor;Motor Activity;motor impairment;motor symptom;Movement;Mus;neural;neural circuit;Neurons;optogenetics;Parkinson Disease;Parkinsonian Disorders;parkinsonian rodent;Parvalbumins;Pathway interactions;Patients;Performance;pharmacologic;Phase;Photometry;Plasma;preservation;Property;response;Reversal Learning;Role;side effect;Substantia nigra structure;success;Testing;Thalamic structure;Therapeutic;Time;Withdrawal

PROJECT_TITLE: Neural Substrates of the long-duration response

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: AMES

ORG_COUNTRY: UNITED STATES

ORG_DEPT: VETERINARY SCIENCES

ORG_FIPS: US

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: PROJECT NARRATIVE  Highly pathogenic avian influenza remains a significant threat to the poultry industry as well as to human health. In fact, human deaths continue to occur throughout the world from these strains. We have developed a universal influenza vaccine to protect poultry and humans from these strains and seek to determine its efficacy.

PI_NAMEs: VERHOEVEN, DAVID E (contact)

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: 1918 influenza pandemic;Adjuvant;Adverse effects;American;Animals;anti-influenza;Antigens;Asia;Asian;Attenuated;Attenuated Vaccines;Avian Influenza;biosecurity;Birds;Cessation of life;chicken egg;Chickens;Circulation;Code;Cold Chains;cold temperature;Containment;cost;cross immunity;delivery vehicle;design;Disease Outbreaks;DNA;Domestic Fowls;efficacy evaluation;efficacy study;egg;Equus caballus;Exposure to;Farm;feeding;Ferrets;flu;Future;future pandemic;hatching;Health;Hemagglutinin;Human;Immunity;Implant;In Vitro;Indiana;Industry;Infection;Influenza;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H3N2 Subtype;Influenza A Virus, H3N8 Subtype;Influenza A Virus, H5N1 Subtype;Influenza Hemagglutinin;influenza virus strain;influenza virus vaccine;Injections;Insecta;Iowa;Licensing;Lipids;Literature;Mammals;manufacture;Meleagris gallopavo;Messenger RNA;Midwestern United States;Molecular Conformation;Mucous Membrane;Mus;Mutate;neutralizing antibody;news;Newspapers;novel;Oral;pathogen;Pathogenicity;Pattern;Persons;Polyanhydrides;Population;Pregnancy;prevent;Prevention;Proteins;receptor;RNA vaccination;RNA vaccine;Rod;Route;Sales;Sea;Speed;Strigiformes;Technology;Tenebrio;Tennessee;Testing;thermostability;Transcript;transgenic insect;Transgenic Organisms;United States Department of Agriculture;universal influenza vaccine;universal vaccine;Vaccinated;Vaccination;vaccine candidate;vaccine delivery;vaccine evaluation;Vaccines;Viral;Virus;Virus Diseases;wild bird

PROJECT_TITLE: Indirect Prevention of High Path Flu Zoonosis through Universal Vaccination

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-Y (02)]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Gene Therapy;Genetics;Immunotherapy;Myasthenia Gravis;Neurosciences;Rare Diseases

ORG_CITY: WASHINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: NARRATIVE Myasthenia gravis is a chronic debilitating autoimmune disease caused by autoantibodies to nicotinic acetylcholine receptor of skeletal muscles. The goal of this proposal is to develop an antigen-specific cell therapy for myasthenia gravis by infusing chimeric antigen receptor-engineered regulatory T cells using a rodent disease model. This study will provide a proof-of-principle for the effectiveness of the therapy and outline a road map for translating the discovery to clinical use.

PI_NAMEs: LUO, JIE  (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Address;Adoptive Transfer;Animal Experiments;Animal Model;Antibodies;Antigen-Presenting Cells;Antigens;assault;Autoantibodies;Autoimmune;Autoimmune Diseases;Autoimmune Responses;autoreactivity;B-Lymphocytes;Binding Proteins;CD8B1 gene;Cell Line;Cell Therapy;Cells;cellular transduction;chimeric antigen receptor;Cholinergic Receptors;Chronic;Clinical;clinically relevant;cytokine;Cytoplasmic Tail;Data;disease model;dosage;Dose;Effectiveness;effectiveness evaluation;effector T cell;Engineering;Epitopes;Experimental Autoimmune Myasthenia Gravis;extracellular;Extracellular Domain;FOXP3 gene;Functional disorder;Generations;Genetic Engineering;Goals;Histopathology;Human;Hybridomas;IL2RA gene;Immunize;immunogenic;Immunosuppression;Impairment;improved;In Vitro;in vivo;Infiltration;Inflammatory;Interleukin-2;lentivirally transduced;manufacture;Maps;Mediating;Methods;Modeling;Modification;Muscle;Myasthenia Gravis;neuromuscular transmission;Nicotinic Receptors;novel;novel strategies;Organ;particle;Pathologic;Patients;Phenotype;Population;pre-clinical;preservation;prevent;Prevention;Rattus;reconstitution;Regulatory T-Lymphocyte;response;Risk Reduction;Rodent;Rodent Diseases;Safety;Schedule;Skeletal Muscle;Specificity;Surface;T cell therapy;T-Cell Proliferation;T-Lymphocyte;Therapeutic;Toxic effect;trafficking;transduction efficiency;Translating;Treatment Efficacy;Work

PROJECT_TITLE: Antigen-Specific Immunosuppression of Myasthenia Gravis by CAR-Engineered Tregs

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Services;Mental Health;Mental Illness;Opioid Misuse and Addiction;Opioids;Post-Traumatic Stress Disorder (PTSD);Social Determinants of Health;Substance Misuse;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: CHARLESTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE d Opioid use disorder (OUD) frequently co-occurs with intimate partner violence (IPV) and posttraumatic stress disorder (PTSD), and there is an imminent need for the development of digital clinical decision-support tools to screen, assess, and appropriately refer individuals with IPV and PTSD to treatment. The proposed study will design and test the implementation and effectiveness of a digital toolkit for screening, referral, and planning for IPV and PTSD in three opioid treatment programs in South Carolina. Findings will demonstrate how a digital toolkit for may reduce IPV and PTSD, increase uptake of referral, and decrease opioid use and associated psychiatric conditions among a population in dire need.

PI_NAMEs: JARNECKE, AMBER  (contact);SARAIYA, TANYA CHANDRESH

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: Address;Adopted;Adoption;Advocacy;Algorithms;Assessment tool;Automation;care seeking;Caring;Clinic;Clinical;clinical decision support;clinical decision-making;Clinical effectiveness;clinical practice;Clinical Trials;Consolidated Framework for Implementation Research;coping;craving;Data;design;Development;Diagnosis;diagnostic criteria;digital;digital intervention;dissemination science;Effectiveness;effectiveness outcome;effectiveness/implementation hybrid;Emotional;evidence base;experience;Feedback;Goals;health care settings;Health Personnel;Health Services Accessibility;implementation evaluation;implementation fidelity;implementation outcomes;implementation science;implementation/effectiveness;Improve Access;improved;Individual;innovation;interest;Interview;intimate partner violence;Knowledge;Maintenance;medication for opioid use disorder;Mental Depression;Mental Health;novel;Opioid;opioid misuse;opioid overdose;opioid treatment program;opioid use;opioid use disorder;opioid withdrawal;Outcome;Pain;patient retention;Patients;Persons;Phase;Population;Post-Traumatic Stress Disorders;Process;programs;Provider;psychoeducation;Randomized;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Reporting;Research;Research Personnel;Resources;Risk;Risk Factors;Safety;screening;screening and brief intervention;Screening procedure;secondary outcome;Service delivery model;Services;Shelter facility;South Carolina;Specialist;Structure;substance use;suicidal;support tools;Survivors;Symptoms;Technology;technology platform;Testing;Time;tool;Training;Translating;Translations;uptake;usability;Violence;violence exposure;web platform;Withdrawal Symptom

PROJECT_TITLE: A Digital Toolkit to Address Intimate Partner Violence in Opioid Use Disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SKP-E (M2)]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Mental Health;Prevention;Rehabilitation;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: CAMBRIDGE

ORG_NAME: CHARLES RIVER ANALYTICS, INC.

ORG_STATE: MA

PHR: Project Narrative No engaging, immersive intervention exists for vaping cessation therapy, and there is no clinical trial to test the efficacy of embedding cognitive behavioral therapy (CBT) content into virtual reality (VR) to increase success at quitting. We are expanding on our previous work, CESSATION—Charles River’s VR-based CBT-embedded app for smoking cessation—to focus on vaping, producing Novel, On-demand VR for Accessible, Practical, and Engaging therapy (NO VAPE). Current vaping cessation treatments lag far behind treatment for other substance use disorders (SUDs); therefore, a commercially available VR app to be combined with hybrid live and digitized CBT or used alone that increases access, reduces costs, is engaging, realistic, available on-demand, and effective for initiating and maintaining abstinence will help more people quit vaping.

PI_NAMEs: BRACKEN, BETHANY K (contact)

PROGRAM_OFFICER_NAME: GUTOWSKI, STACIE MARIE

PROJECT_TERMS: Abstinence;Alcohols;Clinical Trials;Clover;Cognitive Therapy;commercialization;cost;design;efficacy testing;Evaluation;Feedback;Funding;Goals;Grant;Health;Human;Hybrids;improved;Individual;Innovation Corps;Intervention;Interview;Medical Device;meetings;Mental Health;National Institute of Drug Abuse;Nicotine;novel;Persons;Phase II Clinical Trials;Post-Traumatic Stress Disorders;programs;Resources;skills;Small Business Innovation Research Grant;smoking cessation;Stimulant;Substance Addiction;Substance Use Disorder;success;tool;vaping;virtual reality;Work

PROJECT_TITLE: Novel, On-demand VR to Amplify Practice Efficacy (NO VAPE)


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Infectious Diseases;Pediatric

ORG_CITY: EDINBURG

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS RIO GRANDE VALLEY

ORG_STATE: TX

PHR: The objective is to acquire and install state-of-the-art individually ventilated caging in a newly constructed animal facility, which is dedicated to breeding and conducting biomedical research with laboratory opossums. The cages will provide an optimal environment for the animals, and are highly efficient with respect to requirement for energy and provision of care. This laboratory opossum research resource is the only large one of its kind in the world, and it serves the nation’s biomedical research community by providing opportunities for collaborative research on site, and by providing animals and biological materials from them to investigators at other institutions.

PI_NAMEs: VANDEBERG, JOHN L (contact)

PROGRAM_OFFICER_NAME: LI, XIANG-NING

PROJECT_TERMS: Adolescent;Age;Age Months;Aggressive behavior;Air;Allergens;animal care;Animal Experimentation;animal facility;Animal Welfare;Animals;Area;Biocompatible Materials;Biomedical Research;Breeding;care systems;Caring;Cell Nucleus;Censuses;Collaborations;Communicable Diseases;Communities;comparative;Complement;Country;Crowding;Dedications;density;design;Development;Developmental Process;Didelphidae;disease transmission;Educational process of instructing;Embryo;energy efficiency;Environment;Equipment;Evolution;exhaust;Exhibits;experimental study;Faculty;Fetal Development;Funding;Future;Genetic;Goals;Housing;Human;human pathogen;in vivo;Inbred Strain;Individual;Infectious Agent;Institution;Intervention;Laboratories;Laboratory Animals;Location;Mammals;Manufacturer;Marsupialia;Medicine;meetings;member;Modernization;Monodelphis Domestica;Mothers;Motor;Mus;Nature;Outcome;Partner in relationship;Physiological Processes;programs;pup;Quarantine;Research;research facility;Research Personnel;Resources;risk minimization;Risk Reduction;Rodent;Same-sex;Schedule;Secure;Services;sex;Sexual Transmission;Site;Source;Students;System;Technology;Texas;Time;Universities;ventilation;Vertical Transmission;welfare

PROJECT_TITLE: Individually ventilated cage system for laboratory opossum vivarium

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-U (91)]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

ORG_CITY: Chicago

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative The University of Illinois Chicago (UIC) has a robust animal-based research program that supports over $110 million in biomedical research and an average daily census of approximately 40,000 animals. UIC proposes to modernize its centrally managed animal facilities by purchasing and installing a cloud-based environmental monitoring system that will improve animal well-being, safety, regulatory compliance, and ensure experimental reproducibility while also resulting in significant efficiencies in operational management. Such an upgrade will directly improve the institution's animal facility infrastructure to facilitate both biomedical research discoveries and research reproducibility.

PI_NAMEs: FORTMAN, JEFFREY D (contact)

PROJECT_TERMS: Academy;Affect;animal care;Animal Experimentation;animal facility;Animal Housing;Animal Husbandry;Animal Technicians;Animals;Biological;Biomedical Research;Board Certification;Canis familiaris;Cavia;Censuses;Certification;Chemicals;Chicago;cloud based;Communication Methods;Data;Data Collection;Electronic Mail;Ensure;Environmental Monitoring;Equipment;Evaluation;experimental study;Extramural Activities;falls;Family suidae;Fishes;Funding;Goals;Guidelines;hazard;Health;Housing;Human Resources;Humidity;Illinois;improved;Individual;Infrastructure;Institution;Laboratories;Laboratory Animal Medicine;Laboratory Animal Production and Facilities;Laboratory Animals;laboratory facility;Length;Light;Location;member;Modeling;Modernization;Mole Rats;Monitor;Mus;nonhuman primate;Notification;Oryctolagus cuniculus;Personal Satisfaction;Postdoctoral Fellow;Preparation;pressure;prevent;programs;Publishing;Rattus;Reporting;Reproducibility;Research;research facility;Research Personnel;Research Project Grants;Research Support;Resources;response;Risk;Rodent;Safety;sensor;Signal Transduction;Site;square foot;System;Technology;Telephone;Temperature;Text;Time;United States National Institutes of Health;Universities;ventilation;Veterinarians;wireless sensor

PROJECT_TITLE: UIC Animal Facility Environmental Monitoring System


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: PATHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Experience drives structural and functional remodeling of neuronal circuits in the brain during discrete developmental windows called critical periods, after which circuits stabilize. Premature closure of critical periods is thought to contribute to the development of autism spectrum disorders due to an early loss of neural plasticity, and in turn, reduced cognitive flexibility. The experiments outlined in this proposal will test whether critical period plasticity can be reopened and will assesses the structural and functional consequences of boosting neural plasticity in mature circuits.

PI_NAMEs: ACKERMAN, SARAH D (contact)

PROGRAM_OFFICER_NAME: JOHNSON, KARI ANNE

PROJECT_TERMS: Affect;Animal Model;Architecture;Astrocytes;autism spectrum disorder;Award;Behavior;Biological Models;Brain;Cell Shape;Cognitive;critical period;Dendrites;Development;developmental plasticity;Disease;Drosophila genus;Ensure;Environment;Epilepsy;experience;experimental study;Faculty;Failure;flexibility;Genetic;genetic approach;Goals;Human;Immunology;Laboratories;Maintenance;medical schools;Mentors;Microtubules;Molecular;Molecular Genetics;Motor;myelination;nervous system development;neural circuit;Neuroglia;neuronal circuitry;Neuronal Plasticity;Neurons;Neurosciences;neurotransmission;novel;Pathology;Pathway interactions;Pattern;Physicians;Predisposition;premature;reverse genetics;Role;Series;Shapes;Stereotyped Behavior;Structure;Testing;Training;Zebrafish

PROJECT_TITLE: The role of astrocyte-neuron signaling in closing a critical period required for motor circuit structure function and behavior


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Digestive Diseases;Infant Mortality;Lung;Neonatal Respiratory Distress;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: PEDIATRICS

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Bronchopulmonary dysplasia (BPD), also known as chronic lung disease of prematurity, is the most consequential complication of preterm birth and is a leading pediatric cause of disability and early death. Pathologic gastroesophageal reflux (GER) contributes to respiratory disease in >40% of very preterm infants with BPD through induction of bronchospasm, hypoxemia, and aspiration induced lung injury. Transpyloric feeding reduces aerodigestive sequelae of GER in high-risk older children and adults but has uncertain safety and efficacy in infants; this randomized trial will be the first to determine the tolerability and physiologic efficacy of transpyloric feeding to reduce objectively diagnosed GER in preterm infants with BPD.

PI_NAMEs: JENSEN, ERIK ALLEN (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Acids;Adult;Adverse event;Affect;aspirate;Aspiration Pneumonia;Benefits and Risks;Bile Acids;Biological Markers;Birth;Bronchial Spasm;Bronchopulmonary Dysplasia;Cardiac;Caring;Cause of Death;Cessation of life;Child;Childhood;Chronic;Chronic Lung Injury;Clinical;clinical diagnosis;Clinical Research;Cognition;Collection;Complication;Conduct Clinical Trials;cost;cytokine;Data;design;Diagnosis;Diagnostic;diagnostic value;disability;Disease Management;electric impedance;endotracheal;Enrollment;Ensure;Enteral Feeding;Enteral Nutrition;Equilibrium;Esophagus;Event;evidence base;experience;extreme prematurity;feeding;Foundations;Functional disorder;Fundoplication;Future;Gastric Feeding Tubes;Gastroesophageal reflux disease;Goals;Growth;Health;Health Care Costs;Heterogeneity;high risk;Hypoxemia;Impairment;improved;improved outcome;Infant;infant outcome;Infection;Inflammation;injured airway;Intervention;Knowledge;Liquid substance;Lung;Lung Diseases;lung injury;Measures;Methodology;Monitor;mortality;Motility;Multicenter Trials;Narcotics;Neurologic;Operative Surgical Procedures;Oral;Outcome;Pathologic;Pepsin A;Performance;Pharmaceutical Preparations;Physiological;pilot trial;Population;positive airway pressure;Pregnancy;Premature Birth;Premature Infant;primary outcome;Publishing;Pulmonary Inflammation;Randomized;randomized trial;Records;Research;Research Personnel;respiratory;Respiratory Disease;response;Risk;Route;Safety;Saliva;Sampling;secondary outcome;Serious Adverse Event;Severities;Site;Specific qualifier value;Subgroup;success;Testing;Time;tool;treatment effect;treatment response;trial comparing;ventilation

PROJECT_TITLE: Pilot trial comparing transpyloric to gastric feeding in very preterm infants with bronchopulmonary dysplasia

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric

ORG_CITY: PITTSBURGH

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Narrative Cleft Lip and palate is a common, but poorly understood birth defect. It is known to have genetic, epigenetic and environmental causes, yet most animal models for its development only include genetics. Here, we develop an epigenetic model of cleft lip and palate to model how an epigenetic change can cause a cleft to form.

PI_NAMEs: GREEN, REBECCA MICHELLE (contact)

PROGRAM_OFFICER_NAME: CHOU, ALICIA YESIU

PROJECT_TERMS: 3-Dimensional;A/J Mouse;Affect;Animal Model;Apoptosis;Biological;Cells;Cleft Lip;cleft lip and palate;Cleft lip with or without cleft palate;Cleft Palate;Complex;Computer Models;Congenital Abnormality;Data;Development;DNA Methylation;DNA methylation profiling;DNA Transposable Elements;Embryo;Epigenetic Process;epigenome;Exposure to;Face;Family member;Frequencies;Future;Gene Expression;Gene Proteins;Genes;Genetic;Genetic Models;Genetic study;Genotype;Grant;Growth;Human;Imaging Device;Inbred BALB C Mice;Individual;Knock-out;Knowledge;Lead;Link;Maps;Methods;Methylation;model development;Modeling;Modification;Molecular;Monozygotic twins;Morphology;mouse model;Mouse Strains;Mus;Mutation;Nature;nonsyndromic cleft lip with or without cleft palate;novel;orofacial cleft;Penetrance;Phenotype;Prevalence;Proliferating;Property;protein function;Proteins;Retrotransposon;Role;Signal Transduction;Structural Congenital Anomalies;Syndrome;Tertiary Protein Structure;Testing;trait;Transcript;transcriptome sequencing;Variant;Work;Zinc Fingers

PROJECT_TITLE: Epigenotype- Genotype -Phenotype interactions in facial development

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 JC (11)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences

ORG_CITY: EUGENE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: Project Narrative A primary reason we forget is because we store a vast number of memories and interference between these memories becomes inevitable. The proposed research seeks to identify how memories, and corresponding neural representations of memories, adapt to interference such that forgetting is prevented. By establishing fundamental new insight into how the brain resolves interference between similar memories, this research will be broadly relevant to disorders and diseases which affect the memory system.

PI_NAMEs: KUHL, BRICE ALAN (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Affect;Aging;Agreement;Behavioral;Benign;Brain;clinically significant;Code;Complement;Computer Analysis;Computer Models;Computing Methodologies;Confusion;Data;data mining;Dementia;Dimensions;Disease;Doctor of Philosophy;Episodic memory;forgetting;Functional Magnetic Resonance Imaging;Funding;Future;Goals;Hippocampus;Human;insight;Investigation;Learning;Link;Machine Learning;Memory;Methods;Names;neural;neural patterning;neuroimaging;neuromechanism;Neurosciences;novel strategies;Oregon;parent project;Pattern;prevent;programs;Psychology;recruit;Research;Role;System;Techniques;Universities

PROJECT_TITLE: Neural mechanisms for reducing interference during episodic memory formation

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Prevention

ORG_CITY: ORANGEBURG

ORG_NAME: NATHAN S. KLINE INSTITUTE FOR PSYCH RES

ORG_STATE: NY

PHR: NARRATIVE This application requests funds to acquire specialized laboratory mouse housing systems - Digital Ventilated Caging (DVC) designed to initiate a new generation of animal welfare management and research data acquisition. The DVC promotes both ‘Reduction and Refinement’ principles of animal research; automatic data collection reduces errors; and bias and automatic monitoring complements animal welfare initiatives. The core equipment will be shared for use for multiple funded grants at NKI.

PI_NAMEs: KLINGER, MARK M (contact)

PROJECT_TERMS: Accreditation;Aging;Alzheimer's Disease;animal care;Animal Experimentation;animal facility;Animal Housing;Animal Model;Animal Welfare;Animals;Behavior;Behavior monitoring;behavioral study;Biological Markers;Brain;Breeding;Caring;Charities;Communication;Data;data acquisition;Data Collection;design;Development;Diagnostic;digital;Disease;Effectiveness of Interventions;Emotions;Environment;Environmental Monitoring;Equipment;Evaluation;Exercise;experimental study;Foundations;Funding;Gene Deletion;Gene Modified;Generations;Grant;Health;Health Promotion;Home;Hour;Housing;improved;Institution;Laboratory mice;Measurement;Medical Research;Methods;Modeling;Modernization;Molecular;Monitor;monitoring device;mouse model;Mus;Neurodegenerative Disorders;Pathologic;Pathology;Pharmacologic Substance;Phenotype;Physiology;programs;remote monitoring;Request for Applications;Research;Research Personnel;Resource Sharing;Rodent;Running;Schizophrenia;Scientist;Sleep;System;Technology;Transgenic Mice;Transgenic Organisms;Treatment outcome;Trust;United States National Institutes of Health;ventilation;Vision research

PROJECT_TITLE: Use of DVC® systems to acquire and remotely view data for improved monitoring of animal models and their environment.


NIH_SPENDING_CATS: Cystic Fibrosis;Infectious Diseases;Lung;Rare Diseases

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Pseudomonas aeruginosa and Mycobacterium abscessus are versatile opportunistic pathogens that can cause devastating persistent infections. We have demonstrated that P. aeruginosa potently antagonizes M. abscessus when co-cultured as dual-species biofilms and propose that inter-bacterial antagonism of M. abscessus by P. aeruginosa is mediated by a novel antibacterial strategy. This research will directly benefit people with inflammatory and muco-obstructive lung disorders as well as in patients infected with these organisms in wounds and abscesses.

PI_NAMEs: HALL-STOODLEY, LUANNE ;WOZNIAK, DANIEL J (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Abscess;antagonist;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;antimicrobial;biofilm species;bronchial epithelium;Bronchiectasis;Candidate Disease Gene;Cell Culture Techniques;chronic infection;Chronic Obstructive Pulmonary Disease;Clinical;Coculture Techniques;Combined Antibiotics;Communities;Cystic Fibrosis;cystic fibrosis patients;Data;Defense Mechanisms;Development;Disease;Exhibits;experimental study;Genes;Growth;Human;Immunity;In Vitro;in vivo;Incidence;Individual;Infection;Infectious Agent;Inflammatory;inflammatory lung disease;insight;Iron;Libraries;Life Style;lonely individuals;Lung;Lung Diseases;Lung infections;Mediating;Microbe;Microbial Biofilms;microbial community;Microbiology;microorganism;Modeling;mortality;Motility;Mucins;Mus;mutant;Mycobacterium abscessus;Mycobacterium avium;Mycobacterium Infections;Mycobacterium smegmatis;non-tuberculosis mycobacteria;novel;Operative Surgical Procedures;opportunistic pathogen;Organism;Oxygen;pathogen;Patients;Persons;Play;Predisposition;Prevalence;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;public health relevance;Publishing;Reporting;Research;Site;Soft Tissue Infections;Soil;Surface;Testing;Time;transcriptome sequencing;Variant;Water;Work;wound

PROJECT_TITLE: Surface dependent inhibition of Mycobacterium abscessus by Pseudomonas aeruginosa

STUDY_SECTION: IMII

STUDY_SECTION_NAME: Interspecies Microbial Interactions and Infectious Study Section[IMII]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Microbiome;Nutrition;Obesity;Prevention

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Understanding how the immune system is able to interact with the organisms that live on our body has revealed unique immune-microbe interactions that are now known to influence mammalian health. This has yet to be done with our resident viral community. Our proposal will be the first to catalog and identify what commensal viruses interact with antibodies in humans, which has the potential to identify novel viruses that are relevant to human health and will facilitate future mechanistic studies.

PI_NAMEs: ROUND, JUNE LOUISE (contact);STEPHENS, ZAC

PROGRAM_OFFICER_NAME: KIM, HYE-SOOK

PROJECT_TERMS: 16S ribosomal RNA sequencing;adaptive immunity;Animal Model;Animals;Antibodies;Antibody Formation;Antibody Response;Antigens;Archaea;Area;Arizona;Bacteria;bacterial community;Bacteriophages;biobank;Biomedical Research;Catalogs;Child;Clinic;cohort;commensal bacteria;Communities;Dairying;Data;data resource;Diet;dietary;Disease;DNA Binding;Eosinophilic Esophagitis;Excision;fecal transplantation;Feces;Food;fungus;Future;gastrointestinal;Germ-Free;Gluten;Gnotobiotic;Health;Homeostasis;Human;Human body;human microbiota;Idaho;Immune;Immune response;Immune system;Immunity;Immunoglobulin A;Immunoglobulin G;Immunologic Stimulation;Immunology;Individual;Infection prevention;Inflammatory Bowel Diseases;insight;interest;intestinal barrier;intestinal epithelium;Intestinal permeability;Intestines;Mammalian Cell;Microbe;microbiota;Montana;mucosal site;Mucous Membrane;Mus;Native-Born;New Mexico;novel marker;novel virus;Obesity;obesity prevention;Organism;particle;Permeability;Population;predicting response;Publishing;Reaction;Reporting;research facility;responders and non-responders;RNA;Rural;Sampling;Serum;Severities;Shapes;Site;Small Intestines;Sorting;stool sample;Surface;Systems Development;Techniques;tool;transplantation therapy;Underserved Population;Universities;Utah;Viral;virome;Virus;Work

PROJECT_TITLE: Antibody targeting of the virome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-E (50)]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: WORCESTER

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Recent research indicates that conventional health interventions focusing on individual knowledge and behavior are of limited effectiveness. Nutrition based disease in childhood, specifically Early Childhood Caries and obesity, are closely linked to social context and environment. Low income and immigrant children are at particularly high risk. The Mothers’ Action Project for Child Health (MAP- CH) seeks to intervene at the level of social level by creating new social networks for low income South Asian mothers. Mothers living in close proximity will be recruited into Mothers’ Clubs of 10-12 mothers. While receiving health education and skill building over a 12 month program, mothers will engage in activities designed to strengthen social ties among Club members. If successful, the project will provide a model for the development of social network interventions to improve child nutrition-based disease.

PI_NAMEs: FOUNTAIN, CHRISTINE ;KARASZ, ALISON  (contact)

PROGRAM_OFFICER_NAME: MATTIA, JILL

PROJECT_TERMS: Address;aged;arm;Assertiveness;Attitude;Basic Science;Behavior;behavior change;Behavior Therapy;Behavioral;Carbohydrates;Child;Child Health;Child Nutrition;Child Rearing;Childhood;Clinical Trials;Cluster randomized trial;Cognition;cohesion;Communities;comparison control;Data;density;Dental;Dental caries;Dental Hygiene;design;Diagnostic;Diet;Dietary Sugars;Disease;Documentation;early childhood;Educational Curriculum;Educational Intervention;Educational Materials;Effectiveness;efficacy testing;Elderly;empowerment;Environment;experience;feeding;Feeding behaviors;Food;Fostering;Goals;group intervention;Health;health disparity;Health education;Health Promotion;high risk;Home;Home visitation;Household;Immigrant;Immigrant family;implementation evaluation;improved;Incidence;Individual;Infant;Intake;Intervention;intervention effect;Knowledge;Life Cycle Stages;Link;Low income;Maintenance;Measures;Mediating;Mediator;meetings;member;Mental Depression;Metabolic;Milk;model development;Modeling;Monitor;Mothers;Neighborhoods;novel;novel strategies;Nursery Schools;nutrition;Obesity;Oral;Oral health;Outcome;Parenting Education;peer;Persons;Phase;Pilot Projects;Play;Preschool Child;pressure;primary outcome;programs;Protocols documentation;Provider;psychologic;Randomized;recruit;Research;Risk;Role;Safety;Science;skills;social;Social Behavior;Social Environment;social influence;social integration;Social isolation;social media;Social Network;social network intervention;Social Processes;Social support;South Asian;sugar;therapy design;Toddler;treatment arm;treatment effect;United States National Institutes of Health;Weight Gain

PROJECT_TITLE: MAP for Child Health: Using Social Networks to Improve child health and oral health


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Clinical Research;Disability Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: GAINESVILLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative For many individuals with incomplete spinal cord injury, walking recovery is a primary goal. While functional walking requires trunk control and stepping, rehabilitation emphasizes stepping and overlooks trunk control, leaving individuals with severe trunk control impairments that increase fall risk and cause reliance on assistive devices. The proposed project will quantify neuromechanical control of the trunk during walking and provide a foundation to address this critical component of walking function after incomplete spinal cord injury.

PI_NAMEs: HAWKINS, KELLY A (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Abnormal coordination;Acceleration;Achievement;Address;Age;Articular Range of Motion;Articulation;Ataxia;Behavior;Biomechanics;Caring;Chest;Clinical;Clinical assessments;Complex;Cross-Sectional Studies;Equilibrium;Fall prevention;fall risk;Fostering;Foundations;Future;Gait;Gait abnormality;Glean;Goals;Head Movements;Human;Impairment;improved;Individual;insight;Intervention;Investigation;Investments;kinematics;Knowledge;Leg;limb movement;Limb structure;locomotor control;Lower Extremity;Motion;Motor;Movement;Muscle;Neurologic;Neuromechanics;neuromuscular;Pattern;Pelvis;Periodicity;Persons;Phase;Population;Posture;primary outcome;Recovery;Rehabilitation therapy;Research;Resources;Role;Self-Help Devices;sex;Spinal cord injury;synergism;Testing;therapy development;transmission process;Vertebral column;vestibular system;Visual;Walking

PROJECT_TITLE: Trunk control after human spinal cord injury

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD-K]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Drug Abuse (NIDA only);Neurosciences;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: RESTON

ORG_NAME: SPACERX LLC

ORG_STATE: VA

PHR: Project Narra+ve Smoking is responsible for over 8 million preventable deaths annually. Currently, varenicline is the most eﬀec+ve non- nico+ne replacement therapy (non-NRT) for smoking cessa+on. However, its success rate is only 22%, and over 67% of pa+ents discon+nue treatment due to adverse events and ineﬀec+veness. Enhancing varenicline's eﬃcacy and pa+ent compliance could have a signiﬁcant impact on overall health outcomes and healthcare costs. The objec+ve of our STTR Phase I grant is to develop a more eﬀec+ve smoking cessa+on treatment. This will be achieved by crea+ng and tes+ng prodrugs of varenicline with a longer dura+on of ac+on and the ability to be formulated into various administra+on methods. Our prodrugs will be tested to evaluate their impact on speciﬁc markers associated with nico+ne addic+on. The goal is to iden+fy and select the most promising prodrug candidates that stabilize basal dopamine levels and reduce nico+ne self-administra+on. Successful execu+on of our strategy has the poten+al to help over 20 million adult smokers in the US who are trying to quit. Given the overall health impacts of smoking, even a modest increase in eﬃcacy and pa+ent compliance with the best available non-NRT will have a drama+c eﬀect. As part of our development plan, we seek mentorship through the I- Corps™ program to help us deﬁne the unique value proposi+on for our prodrug.

PI_NAMEs: BETLEY, JOHN NICHOLAS;LEE, PETER H (contact)

PROGRAM_OFFICER_NAME: NGUYEN, TAM L

PROJECT_TERMS: Address;Adult;Adverse event;Biological Markers;Biosensor;Brain;Corpus striatum structure;craving;Data;design;Development Plans;Dopamine;Drama;drug candidate;Dura Mater;Failure;FDA approved;Goals;Grant;Health;Health Care Costs;improved;in vivo;Innovation Corps;Insurance Carriers;Knowledge;Marketing;Mentorship;Methods;Monitor;novel;novel therapeutics;Oral;Outcome;Pharmaceutical Preparations;Phase;Physicians;premature;preventable death;Prodrugs;programs;Replacement Therapy;response;Rewards;side effect;Signal Transduction;Small Business Innovation Research Grant;Small Business Technology Transfer Research;Smoker;Smoking;smoking cessation;Smoking treatment;success;Testing;Therapeutic Effect;Time;varenicline;Work

PROJECT_TITLE: Using in-vivo Real-time Biosensor to Evaluate Prodrugs Designed to Prolong Therapeutic Effects for Smoking Cessation.


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The gene, protein and lipid changes that contribute to the enlargement of adipocytes or hypertrophy resulting in obesity remain largely unknown. This gap in knowledge limits the ability to successfully develop therapeutics for weight loss or weight gain prevention, which we aim to address using our novel model of adipocyte hypertrophy in combination with an unbias multi-omic approach. In addition to providing critical insight into the cellular processes underlying adiposity, the proposed studies have the potential to identify Zfp949 gene regulation as a possible therapeutic candidates for obesity and other lipid-associated disorders.

PI_NAMEs: RUIZ, HENRY H (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Address;Adipocytes;Adipose tissue;Body Weight decreased;Brown Fat;Cardiovascular Diseases;cardiovascular risk factor;Cell model;Cell Physiology;Cells;Characteristics;clinically significant;Collaborations;comparison control;Data;Diabetes Mellitus;Diet;diet-induced obesity;dietary manipulation;Disease;Embryonic Development;Event;Exhibits;experimental study;Exposure to;Family;Fatty acid glycerol esters;fatty acid oxidation;Fatty Acids;Fatty Liver;fatty liver disease;Future;Gene Expression;Gene Expression Regulation;gene repression;gene-targeted therapy;Genes;Genetic;genetic manipulation;Genetic Transcription;High Fat Diet;human subject;Hypertrophy;Impairment;In Vitro;in vivo;innovation;insight;Insulin;Insulin Resistance;knock-down;Knockout Mice;Knowledge;Laboratories;Light;Link;lipid biosynthesis;lipid metabolism;lipidome;lipidomics;Lipids;Literature;Liver;Mediating;Metabolic Pathway;Modeling;mouse model;multiple omics;Mus;new therapeutic target;novel;Obesity;obesity prevention;obesity treatment;Oleates;overexpression;Palmitates;Pathogenesis;Pathway interactions;Physiological;Play;precursor cell;Prevalence;prevent;Prevention;Process;programs;protein function;Proteins;Proteome;Proteomics;Publishing;Regulation;Reporting;Rest;Risk;Role;Sampling;Techniques;Testing;Therapeutic;therapeutic candidate;therapeutic target;Thinness;tool;Transcription Repressor;transcriptome;transcriptome sequencing;Triglycerides;Up-Regulation;weight gain prevention;Wild Type Mouse;Zinc Fingers

PROJECT_TITLE: Zinc Finger Protein 949 as a Potential Transcriptional Suppressor of Adipocyte Hypertrophy - Resubmission - 1

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: CA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Hematology;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ROCHESTER

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Acute myeloid leukemia (AML) is the most aggressive type of adult leukemia that results in less than 30% of 5- year survival rates. Most AML studies focus on discovering the intrinsic mutations that generate AML cells, however, less is known about the role of the bone marrow microenvironment (BMME) in progressing the disease. The project is taking an innovative approach to explore the role of CCL3-mediate BMME dysregulation and polypharmacy impact during AML chemotherapy using an in vitro model of the human BMME-on-a-chip.

PI_NAMEs: SHARIPOL, AZMEER  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: 3-Dimensional;Acute leukemia;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adult;adult leukemia;Adverse drug event;adverse outcome;aging population;Apoptosis;Award;Azacitidine;Bioinformatics;Blast Cell;Bone Marrow;Cancer Biology;cancer cell;cancer therapy;Captopril;career;Career Choice;CCL3 gene;CCR1 gene;CCR5 gene;CD34 gene;Cell Communication;Cell Compartmentation;Cell Differentiation process;cell growth;Cell Lineage;Cell Maintenance;Cell Physiology;Cells;Cessation of life;chemokine;Chemoresistance;chemotherapy;Clinical Pharmacology;clinically relevant;Collection;Colony-Forming Units Assay;comorbidity;Cytarabine;Data;Daunorubicin;Diagnosis;Disease;disease mechanisms study;Distress;drug discovery;Drug Interactions;Encapsulated;Endothelial Cells;Endothelium;Enzyme-Linked Immunosorbent Assay;Fellowship;Fibrin;Flow Cytometry;Goals;Hematopoiesis;Hematopoietic stem cells;High Prevalence;high risk;Homeostasis;Human;human model;Hydrogels;improved;In Vitro;in vitro Model;in vivo;in vivo Model;inhibitor;innovation;Knowledge;leukemia;leukemia treatment;Ligands;Malignant Neoplasms;Marrow;Mediating;Mentors;Mentorship;Messenger RNA;Metformin;Methodology;Microfluidics;microphysiology system;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Mutation;Myelogenous;Osteoblasts;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Physiological;Polypharmacy;Population;post-doctoral training;Postdoctoral Fellow;predicting response;Proteins;Publishing;receptor;Relapse;Research;Research Personnel;Research Project Grants;Role;Signal Transduction;single-cell RNA sequencing;skill acquisition;skills;small molecule inhibitor;Stains;standard of care;stem cell proliferation;stem cells;Stromal Cells;Structure;Survival Rate;System;three-dimensional modeling;Training;treatment response;Umbilical vein;Work

PROJECT_TITLE: Investigating the Microenvironmental Dysregulation and Polypharmacy Impact during Acute Myeloid Leukemia in an in vitro model of the human bone marrow and in vivo models.

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-U (M1)]


NIH_SPENDING_CATS: Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Microbiome;Prevention;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE “Ending the HIV Epidemic in the US” is an ambitious initiative launched in 2019, aiming to eradicate HIV by 2030 in the United States. To achieve this, a critical need is to identify the root causes contributing to HIV acquisition. Finding causal effects between drug use disorders and HIV acquisition and how these causal effects are mediated by the hosts’ gut microbiota and immune responses are essential for designing effective prevention and intervention strategies, guiding public health policies, understanding the mechanisms involved, and ultimately reducing the burden of HIV in populations affected by drug use.

PI_NAMEs: MA, SHUANGGE ;YANG, BAO-ZHU  (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: Acceleration;Address;Affect;Aging;Antigen-Antibody Complex;Biological Markers;Cannabis;causal model;Cells;Clinical;Cocaine;cohort;Cohort Studies;Complex;computer framework;Data;Data Pooling;Data Set;design;Development;Disease Management;disorder risk;Drug abuse;Drug usage;Drug Use Disorder;Epidemic;Equilibrium;Etiology;Exhibits;experience;Gastrointestinal tract structure;Genetic;Genetic Markers;genetic variant;genome wide association study;genome-wide;gut dysbiosis;gut microbiome;gut microbiota;Health Policy;HIV;HIV Genome;HIV risk;HIV/AIDS;Home;Human;Immune;Immune response;Immune Targeting;indexing;Individual;Inflammation;Injections;insight;Intervention;Investigation;Knowledge;Linkage Disequilibrium;marijuana use disorder;Mediating;Mediation;Mediator;Mendelian randomization;Meta-Analysis;Methods;Microbe;microbial;microorganism;Neuroimmune;neuroinflammation;Neurologic;Nicotine;novel;Opioid;Organ;Outcome;Persons;Pharmaceutical Preparations;Play;pleiotropism;Population;Predisposition;Prevention strategy;programs;Public Health;Reporting;Research;response;Role;Sampling;Shapes;specific biomarkers;statistics;Stimulant;Substance Use Disorder;System;Tobacco;trait;United States;Variant;Veterans

PROJECT_TITLE: HIV Complex Causal Modeling: Gut Microbiome, Drug Use, and Immune Responses

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 LXF-E (M1)]


NIH_SPENDING_CATS: Aging;Brain Disorders;Genetics;Human Genome;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: DURHAM

ORG_DEPT: NEUROLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative The most common cause of idiopathic and familial Parkinson’s disease, an adult onset movement neurodegenerative disorder, are mutations in leucine-rich repeat kinase 2 (LRRK2). The overarching goal of this proposal is to understand how the DNA repair enzyme PARP1 impacts mitochondrial function. It is hoped that cellular pathways involved in maintaining genome integrity will reveal potential new therapeutic strategies to treat this devastating disease.

PI_NAMEs: SANDERS, LAURIE H (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Adult;Automobile Driving;Bioenergetics;career;Cell Death;Complement;Data;Disease;Disease Progression;DNA Damage;DNA lesion;DNA Repair;DNA Repair Enzymes;experimental study;Functional disorder;Genetic;genome integrity;Goals;Grant;Idiopathic Parkinson Disease;Impairment;insight;Lead;Learning;LRRK2 gene;Mediating;Methodology;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial genome;Molecular;Movement;Movement Disorders;Mutation;Nerve Degeneration;Neurodegenerative Disorders;novel therapeutic intervention;novel therapeutics;Parkinson Disease;Pathogenicity;Pathway interactions;Persons;Phenotype;Phosphotransferases;Play;Proteins;Publishing;Reactive Oxygen Species;Research;response;Role;Signal Transduction;Technical Expertise

PROJECT_TITLE: Mechanisms of mitochondrial genome integrity in familial and idiopathic Parkinson's disease


ADMINISTERING_IC: HL

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Arthritis;Back Pain;Behavioral and Social Science;Chronic Pain;Neurosciences;Pain Research;Prevention;Sleep Research;Social Determinants of Health

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because chronic pain imposes a substantial burden on the healthcare system and exerts an enormous impact on the quality of life of approximately 20-30% of U.S adults and their families. As poor sleep is a risk factor of chronic pain, understanding specific mechanisms of how sleep impacts chronic pain is important. The proposed research is directly relevant to the part of NIH's mission that pertains to improving the health of the nation by conducting research onsleep and pain.

PI_NAMEs: LEE, SOOMI  (contact)

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: actigraphy;Adult;Affect;Affective;alertness;Back Pain;Behavior;Behavior Therapy;Behavioral;Behavioral Mechanisms;Biological;Black race;Characteristics;chronic pain;chronic painful condition;Clinical;cohort;Cohort Studies;Degenerative polyarthritis;Development;Dimensions;experience;Family;Frequencies;Friends;Functional impairment;Funding;Future;Health;Health behavior;Healthcare Systems;high risk;improved;Individual;Inflammation;Inflammatory;inflammatory pain;Influentials;insight;Intervention;Joints;knee pain;Life;Life Style;Link;Measures;Mediating;Mediator;meetings;Mental Health;middle age;Mission;Multicenter Studies;neural circuit;Nonpharmacologic Therapy;older adult;older men;Outcome;Pain;Pain interference;Pain management;pain outcome;pain perception;Pain Threshold;Pathway interactions;Patient Self-Report;Pharmaceutical Preparations;physical conditioning;Polysomnography;poor sleep;Population;Prognostic Marker;Public Health;Quality of life;Race;Reporting;Research;Risk;Risk Factors;Sampling;satisfaction;Sensory;Severities;sex;Sleep;Sleep Disorders;Sleep disturbances;sleep health;sleep pattern;sleep quality;social;social disparities;social engagement;sociodemographics;Subgroup;systemic inflammatory response;Time;United States;United States National Institutes of Health;Visit;volunteer;Withdrawal;Woman

PROJECT_TITLE: Sleep, Pain, Active Social Life, and Inflammation (SPAI)

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: BOSTON

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: NEW ENGLAND COLLEGE OF OPTOMETRY

PHR: PROJECT NARRATIVE Measurement of the axial length (AL) of the eye has wide applications in eye research and clinical practice; however, it relies on an estimate of the refractive index of the lens (NLens), which has never been accurately measured for individual eyes in vivo. The primary goal of this proposed project is to combine a ray-traceable Scheimpflug imaging system (RTSI), developed recently by the contact PI, Dr. He, with a whole-eye OCT (WE- OCT) to measure the (NLens) and axial length (AL) simultaneously for human eyes in vivo. This system will be used to derive accurate AL measurements for a group of young adults and cataract patients and will present a substantial breakthrough in the methodology for accurately measuring the AL of the eye.

PI_NAMEs: HE, JI CHANG (contact);WANG, JIANHUA

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Affect;Anterior;anterior chamber;Cataract;Cataract Extraction;Clinic;clinical care;clinical practice;Clinical Treatment;Cornea;Crystalline Lens;Development;direct application;experimental study;Eye;Eye Segment;Goals;Human;Image;imaging system;Implant;improved;in vivo;Individual;individual variation;insight;Intraocular lens implant device;Intraocular Lens Implantation;Investigation;Laboratories;Length;lens;Measurement;Measures;Methodology;Methods;Myopia;novel;Operative Surgical Procedures;Ophthalmology;Optometry;Patient Care;Patients;Positioning Attribute;Postoperative Period;Refractive Errors;Refractive Indices;Research;research study;Role;Site;System;Techniques;Testing;Thick;Vision;Visual;Visual Accommodation;Vitreous Chamber;young adult

PROJECT_TITLE: Investigation of the effect of lens refractive index on the measurement of axial length of the human eye for accommodation and cataract surgery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease;Microbiome

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will reveal specific details about how microbes and the host interact during a critical developmental period of early-life to determine invariant Natural Killer T (iNKT) cell levels and susceptibility or resistance to enteric diseases in later-life. Such information is of potential im- portance to diseases of the esophagus (e.g. eosinophilic esophagitis), small intestine (e.g. celiac disease) and colon (e.g. infections, cancer and inflammatory bowel disease) where iNKT cells have been shown to play a role. The proposed studies are relevant to the mission of the NIDDK because they will identify a new cell type that regulates immune cells and provide information that could be potentially used to prevent or treat mucosal dis- eases that depend upon iNKT cells.

PI_NAMEs: BLUMBERG, RICHARD S (contact)

PROGRAM_OFFICER_NAME: PERRIN, PETER J

PROJECT_TERMS: Address;Adult;Antibiotic Therapy;Birth;Bone Morphogenetic Proteins;Celiac Disease;Cell Count;Cell Physiology;Cell Proliferation;cell type;Cells;Colitis;Collaborations;Colon;commensal microbes;critical developmental period;critical period;Cytotoxic T-Lymphocytes;Development;Disease;Disease susceptibility;Embryo;Emigrant;Engraftment;Enteral;enteric pathogen;Eosinophilic Esophagitis;Esophageal Diseases;Event;fetal;genetic approach;Geography;germ free condition;Germ-Free;Goals;Human;Immune;Immune system;imprint;Infection;Inflammatory Bowel Diseases;insight;Intestines;Lamina Propria;late life;Life;Long-Term Effects;Lymphocyte;Macrophage;Malignant Neoplasms;Mediating;Microbe;microbial;microbiota;Mission;Molecular;mouse model;Mucous Membrane;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;Neonatal;novel;Outcome;Oxazolone;pathogen;Pathogenesis;Pathology;Pathway interactions;pharmacologic;Phenotype;Play;Population;Predisposition;prevent;Public Health;Regulation;Research;Research Proposals;Residencies;Resistance;Role;Signal Transduction;Signaling Protein;single-cell RNA sequencing;Small Intestines;Stromal Cells;T-Cell Proliferation;Testing;Thymus Gland;Time;Tissues;transcriptome;Ulcerative Colitis;Weaning

PROJECT_TITLE: Characterization of Mucosal Lymphocytes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-Y (05)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: LUBBOCK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: TEXAS TECH UNIVERSITY HEALTH SCIS CENTER

PHR: Public Health Relevance Statement (Project Narrative) Alzheimer’s disease (AD) is a slowly progressing disease with significant health, social and occupational consequences, but its subtle development and untreatable nature require broader understanding of the underlying molecular mechanisms leading to it. The proposed research project focuses on alternative polyadenylation (APA) as a molecular mechanism regulating protein expression in a cell type-specific manner in the brain during the development of AD. The successful completion of the project’s aims will provide knowledge about molecular pathways altered by APA in AD in a cell type-specific manner, thus contributing to the development of new therapies for the prevention and/or treatment of Alzheimer’s disease.

PI_NAMEs: GROZDANOV, PETAR  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: 3' Untranslated Regions;abeta accumulation;Abeta clearance;abeta toxicity;Advanced Development;Affect;Age;Alternative Splicing;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease patient;American;Amyloid beta-Protein;Animal Model;Applications Grants;Astrocytes;bioinformatics pipeline;Brain;brain cell;Brain Diseases;Brain region;Cell Nucleus;Cell Physiology;cell type;Cells;Cessation of life;Code;computational pipelines;Data;Data Set;Dementia;design;Development;differential expression;Disease;Etiology;Excision;Executive Dysfunction;extracellular;Fluorescent in Situ Hybridization;Foundations;Functional disorder;Future;Gene Expression;Gene Expression Regulation;gene interaction;Genes;Glial Fibrillary Acidic Protein;Global Change;Goals;Health;High-Throughput Nucleotide Sequencing;Human;human subject;hyperphosphorylated tau;Impaired cognition;Impairment;In Situ Hybridization;Individual;innovation;insight;Intervention;Knowledge;Length;Link;Memory Loss;Messenger RNA;Molecular;Nature;neural;Neurodegenerative Disorders;Neuroglia;neuroinflammation;neuron loss;Neurons;novel;novel therapeutics;Occupational;Open Reading Frames;Pathway interactions;Pattern;Persons;pharmacologic;Physiology;Polyadenylation;Polyadenylation Pathway;Post-Transcriptional Regulation;Prefrontal Cortex;Prevention therapy;Production;protein expression;Protein Isoforms;Proteins;public health relevance;Publishing;Research Project Grants;RNA;Role;Senile Plaques;sex;single nucleus RNA-sequencing;Site;Slice;social;Specificity;Symptoms;Synapses;synaptic function;tau Proteins;Technology;therapeutic development;Transcript;transcriptome;transcriptomics;Translations;Untranslated Regions

PROJECT_TITLE: Cell Type-Specific Alternative polyadenylation of mRNA in Alzheimer's disease

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The goal of this proposal is to study the human virome in tissues from across the whole-body and determine the mechanisms by which viruses persist in these deep tissues. We will leverage the unique San Francisco POstmortem Systematic InvesTigation of Sudden Cardiac Death (POST SCD) study and our prospective tissue collection cohort for in-depth study of host-virus responses that facilitate the virome and impact overall health.

PI_NAMEs: HENRICH, TIMOTHY JENSEN (contact);TSENG, ZIAN H

PROJECT_TERMS: adaptive immune response;Address;Adult;Anatomy;Area;aspirate;Autopsy;Award;Biopsy;Birth;Blood;Body System;Bone Marrow;Brain;Cells;Cellular Tropism;Cessation of life;Clinical;co-infection;cohort;County;COVID-19;COVID-19 pandemic;Cryopreservation;Development;end stage disease;Environment;Formalin;Fostering;Funding;Gene Expression;Genes;Goals;Health;Heart;Histologic;Hospitals;Human;Human body;human disease;Human Papillomavirus;human tissue;human virome;Immune;Immune response;immunoregulation;In Situ;In Situ Hybridization;in vivo;Individual;Infection;Inflammation;Inflammatory Response;Innate Immune Response;innovation;Inpatients;insight;interest;Investigation;Knowledge;life span;Link;Liver;Lung;lymph nodes;Messenger RNA;Metagenomics;microbiome;Morbidity - disease rate;National Heart, Lung, and Blood Institute;novel;Nucleic Acids;Outpatients;Pancreas;pandemic disease;Paraffin Embedding;Pathogenicity;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Play;Population;post SARS-CoV-2 infection;Post-Acute Sequelae of SARS-CoV-2 Infection;post-COVID-19;pressure;programs;prospective;protein expression;Proteins;Proteomics;Protocols documentation;Proviruses;Research;Research Project Grants;Resolution;Respiratory System;response;Role;Sampling;San Francisco;sex;sex assigned;Skin colonization;Spleen;Stress;Structure of parenchyma of lung;sudden cardiac death;Sudden Death;Surveys;Testing;Time;Tissue Banks;Tissue Sample;Tissues;transcriptomics;Viral;Viral Load result;virome;Virus;Virus Diseases;Visualization

PROJECT_TITLE: Whole Body Deep Tissue Characterization of the Human Virome


NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Microbiome;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project narrative Abnormal gut microbiota (dysbiosis) has been implicated in the pathogenesis and progression of Parkinson’s disease (PD), but definitive evidence is lacking. We propose a cross-sectional and longitudinal study to collect symptoms, biomarkers, and microbiota data from PD patients of different phenotypes and demographics (both White and Black populations), with age- and sex- matched healthy controls included as well. We will test the hypothesis that dysbiosis and microbiota metabolomics are markers of PD phenotypes, predictive of the development and progression of PD and PD phenotypes, and potential targets for disease modifying therapies.

PI_NAMEs: CHANG, EUGENE B;XIE, TAO  (contact)

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: Address;Affect;Age;alpha synuclein;arm;Artificial Intelligence;Back;Biochemistry;Biological Markers;Biopsy;Black Populations;Black race;Brain;Chicago;Clinical;clinical phenotype;Clinical Research;cohort;Communities;Constipation;Data;Data Coordinating Center;Databases;demographics;Deposition;Development;Disease;disease phenotype;Disease Progression;disorder prevention;Disparity;distrust;dopamine transporter;drivers of aging;dysbiosis;early onset;fecal microbiota;Foundations;Gait abnormality;Generations;Genetic;Goals;gut dysbiosis;gut microbiome;gut microbiota;gut-brain axis;Health;health care availability;Incidence;insight;Intervention;Knowledge;Link;longitudinal analysis;Longitudinal Studies;Machine Learning;machine learning algorithm;Measures;Mediator;Medical;Medicine;Metabolic;metabolome;metabolomics;Metadata;microbial;microbiome;microbiome therapeutics;microbiota;migration;motor symptom;multidisciplinary;Neurobiology;Neurology;non-motor symptom;novel;Onset of illness;Parkinson Disease;Pathogenesis;Pathologic;Pathology;patient population;Patients;Phenotype;Play;posture instability;predictive marker;Prevalence;prevent;Prognosis;prognostic assays;Race;Randomized;Recording of previous events;Reporting;Research;Research Design;Role;Sampling;Severities;sex;Side;Skin;Socioeconomic Status;statistics;Symptoms;System;Technology;Testing;therapy development;Time;tool;Training;Transfer RNA;Tremor;Universities;Urban Community;urban underserved;Validation;Variant

PROJECT_TITLE: A cross-sectional and longitudinal study of gut microbiota in Parkinson's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-C (M2)]


ORG_CITY: PITTSBURGH

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Narrative: Functional near-infrared spectroscopy (fNIRS) is a popular neuroimaging method for pediatric brain imaging studies. However, since the sensitivity of fNIRS varies exponentially with the depth of the brain from the sensors placed on the scalp, it is impossible to distinguish between changes in the magnitude of evoked brain activity signals and changes in thicknesses of the extracerebral layers of the head or systematic variations in anatomy. This project introduces a novel analysis approach to use priors on the distribution of structural factors extracted from existing databases of structural MRI to incorporate marginal anatomical uncertainty per demographics as part of group level statistical tests for fNIRS in pediatric studies.

PI_NAMEs: HUPPERT, THEODORE JAMES (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Age;age group;Analysis of Variance;Anatomy;Blood;blood oxygen level dependent;Brain;Brain imaging;cerebral hemodynamics;Cerebrospinal Fluid;Cerebrum;Childhood;cognitive task;Computer software;connectome;Data;Data Set;Databases;Dedications;Demographic Factors;demographics;Development;Electroencephalography;Environment;Equation;Equipment;Functional Imaging;Functional impairment;Functional Magnetic Resonance Imaging;functional near infrared spectroscopy;Gender;Goals;Head;Hemoglobin;Heterogeneity;Human;imaging study;Imaging Techniques;improved;Infant;Length;Light;light weight;Location;Longitudinal Studies;Magnetic Resonance Imaging;Measurement;Measures;Mediation;Methods;Modality;Modeling;Monte Carlo Method;Movement;neuroimaging;novel;open source;optical sensor;Optics;Oxygen;Performance;Photons;Population;Positioning Attribute;Property;Publications;Race;Records;Reporter;Sampling;Scalp structure;Sensitivity and Specificity;sensor;Signal Transduction;simulation;Sinus;Statistical Bias;Statistical Distributions;Statistical Methods;structural determinants;Structure;Surface;System;Systematic Bias;Techniques;Technology;Testing;Thick;Tissues;Uncertainty;United States National Institutes of Health;Variant;Work;Writing;X-Ray Computed Tomography

PROJECT_TITLE: Mitigating the statistical bias due to anatomical variation in pediatric fNIRS

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative Periodontitis, one of the most prevalent oral diseases, is a leading cause of tooth loss, but standard mechanical debridement cannot effectively treat patients with severe periodontitis. This project aims to develop engineered cytokine-secreting Limosilactobacillus reuteri encapsulated in a microneedle patch to treat periodontitis in preclinical models. The results will advance the applications of engineered microorganisms combined with novel biomaterials in treating periodontitis through host modulation.

PI_NAMEs: LEE, CHUN-TEH  (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Adult;Affect;Alginates;alveolar bone;Alveolar Bone Loss;Animals;Anti-Inflammatory Agents;Area;Bacteria;Biocompatible Materials;biomaterial compatibility;Biotechnology;Blood;Cells;Characteristics;chronic inflammatory disease;Clinical;clinical application;clinical efficacy;combinatorial;cytokine;Debridement;Diet;Disease;Dose;dysbiosis;Effectiveness;Encapsulated;Engineering;Etiology;Frequencies;Gel;Genes;Genetic;Genetic Engineering;Gingiva;Goals;healing;Human;Hydrogels;Immune;Immune response;improved;Inflammation;Inflammatory Bowel Diseases;inflammatory marker;Interleukin-10;Ligature;malignant mouth neoplasm;Measures;Mechanics;Methods;Microbe;microbial;Microbial Biofilms;microbiota;microorganism;Modeling;Molecular;mouse model;Mouth Diseases;Mus;National Health and Nutrition Examination Survey;Needles;novel;novel strategies;Oral;Oral cavity;oral microbial community;Osteitis;Outcome;Pathogenesis;Patients;Periodontal Diseases;Periodontitis;Pharmaceutical Preparations;Phenotype;polydimethylsiloxane;pre-clinical;Pre-Clinical Model;Probiotics;programs;Proteins;Severities;side effect;Site;standard care;synthetic biology;System;Testing;Therapeutic;Therapeutic Agents;Tissues;tool;Tooth Loss;Tooth structure;United States

PROJECT_TITLE: Engineered Cytokine-Secreting Bacteria to Treat Periodontitis.

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Neurodegenerative;Neurosciences;Rare Diseases

ORG_DEPT: PHYSIOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative The proposed research is relevant to public health because the GGGGCC hexanucleotide repeat expansion in the C9orf72 locus is the most common cause of amyotrophic lateral sclerosis (ALS) and the related neurodegenerative disorder, frontotemporal dementia (FTD). We propose to apply our DNA methylation editing tools to study the epigenetic mechanisms contributing to the pathogenesis of C9orf72 ALS/FTD. Precise editing of C9orf72 methylation will establish the functional role of these epigenetic events in the pathogenesis of C9orf72 ALS/FTD and demonstrate the therapeutic potential that editing methylation may have for the most commonly known cause of ALS/FTD.

PI_NAMEs: LIU, X. SHAWN (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Affect;ALS patients;Amyotrophic Lateral Sclerosis;Bacterial Artificial Chromosomes;Brain region;C9ORF72;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CpG Islands;Defect;Development;Diagnosis;Dipeptides;Disease;Disease Progression;DNA Methylation;DNA methylation profiling;effective therapy;Epigenetic Process;Etiology;Event;Fibroblasts;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Future;Genetic;Genetic Transcription;Genome;Human;Hypermethylation;induced pluripotent stem cell;loss of function;Methylation;methylome;Motor;Motor Neurons;Mus;mutant;Mutation;Neurodegenerative Disorders;Neurons;novel;Onset of illness;Pathogenesis;Pathologic;Patients;Phenotype;Play;Prefrontal Cortex;promoter;protective factors;Proteins;Public Health;Research;Risk;RNA;Role;Sampling;Signal Transduction;Signs and Symptoms;Skin;Testing;Therapeutic;tool;Transcript;transcriptome;transcriptome sequencing;Transgenic Mice;Twin Studies;Variant

PROJECT_TITLE: Epigenetic mechanisms contributing to the pathogenesis of ALS/FTD with GGGGCC repeat expansion mutation at the C9orf72 locus

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: The research proposed here is relevant to the mission of the NIH because understanding how networks of gene expression are generated in individual neurons is critical to understanding how these neurons arise and function, and understanding how individual neurons arise and function is critical to understanding normal and aberrant function of the human nervous system.

PI_NAMEs: NORRIS, ADAM  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Affect;Alternative Splicing;Behavior;Caenorhabditis elegans;Cataloging;cell type;Cells;combinatorial;CRISPR/Cas technology;Data;Defect;Depressed mood;Development;Dissection;egg;experimental study;Gene Expression;Gene Expression Regulation;gene network;Genes;Genetic;Genetic Techniques;Goals;Human;in vivo;Individual;innovation;insight;Lead;Link;Mediating;Mission;Modeling;Molecular;Molecular Analysis;mutant;Nematoda;Nervous System;neuron development;Neurons;Outcome;Pattern;Phenotype;Phosphotransferases;Positioning Attribute;programs;Property;Regulation;Reporter;Research;RNA;RNA Splicing;RNA-Binding Proteins;Sensory;Shapes;Sorting;Specific qualifier value;Testing;tool;Touch sensation;Transcript;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Work

PROJECT_TITLE: COORDINATE CONTROL OF INDIVIDUAL NEURONAL TRANSCRIPTOMES BY TRANSCRIPTION FACTORS AND RNA BINDING PROTEINS

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_DEPT: PHARMACOLOGY

PHR: Project Narrative Orphan G Protein Coupled Receptors (oGPCRs) constitute an untapped pool of pharmacological targets. Here, we will adopt optimized tools and cell-based assays to identify endogenous and synthetic candidate ligands for GPR156, a clinically relevant drug target for treating hearing and balance disorders. At the same time, we will define the components of the signaling complex involving GPR156 in establishing planar cell polarity in hair cells of the inner ear.

PI_NAMEs: ORLANDI, CESARE  (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: Address;Adopted;Affinity;Animals;aqueous;Area;Auditory;Baculoviruses;Binding;Biochemical;Biological Assay;Biology;Biosensor;Brain;candidate selection;Cells;Central Nervous System;Chemicals;Chimeric Proteins;clinically relevant;Cloning;Collaborations;Complex;Coupled;Coupling;Custom;Cyclic AMP;Data;deafness;delta opioid receptor;design;disease-causing mutation;Drug Targeting;Engineering;equilibration disorder;Equilibrium;Equipment;Family;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Gene Mutation;Generations;Genomics;Goals;GTP-Binding Proteins;Hair Cells;Hearing problem;Human;In Vitro;in vivo;Inner Hair Cells;innovation;Knock-in Mouse;Label;Labyrinth;Libraries;Ligands;Mammalian Cell;Mass Spectrum Analysis;Measurement;Mediating;member;Methods;Modeling;mouse genetics;mouse model;Mouse Strains;Mus;Names;nanobodies;Nature;neurophysiology;Noise;novel;novel therapeutics;Organ;Organ Culture Techniques;Orphan;Outcome;Output;Patients;Pattern;Peptide Library;Peptides;pharmacologic;Pharmacology Study;Physiological;Physiology;planar cell polarity;plasma protein Z;Plasmids;Process;Property;Protein Family;protein protein interaction;Proteins;Proteomics;receptor;Receptor Activation;Reproducibility;Research;Resources;Role;Route;screening;Screening procedure;sensor;Sensory;Sensory Hair;Signal Transduction;stable cell line;System;Technology;Testing;therapeutic target;Time;Tissues;tool

PROJECT_TITLE: Discovery of synthetic and endogenous ligands for orphan GPCR GPR156

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Rare Diseases

ORG_CITY: ALBUQUERQUE

ORG_NAME: NEURINSIGHT, LLC

ORG_STATE: NM

PHR: Narrative Surgical removal of brain tumors requires a delicate balance between maximum resection of the tumor and maximum preservation of neurological function, also known as maximum safe resection. Resting-state functional Magnetic Resonance Imaging (MRI) is a rapidly developing approach for presurgical mapping of cortical brain function that does not require patient participation. It can complement task-based functional MRI in patients who have difficulties performing tasks and can efficiently map a large number of functional brain systems to guide surgery. It replaces traditional approaches of functional MRI that require patient participation in patients with functional impairment and holds considerable promise for intra-operative guidance of minimally invasive surgery. Here, we propose a fully automated, highly sensitive and cost-effective real-time resting-state functional Magnetic Resonance Imaging analysis software tool on a custom high-performance computer workstation for presurgical and intraoperative mapping of cortical brain function, building on TurboFIRE, a powerful real-time rtfMRI and sfMRI analysis software tool and the success of a prior Phase I STTR program. This approach meets urgent clinical needs and has high commercial potential for seamlessly integrating resting-state functional Magnetic Resonance Imaging into the clinical workflow of presurgical planning and intra-operative MRI. This technology will have significant clinical and commercial potential for a wide range of neurological and psychiatric applications beyond pre-surgical mapping in patients with brain tumors. It opens up functional brain mapping to patient populations that have been difficult to study in the past.

PI_NAMEs: DENNIG, DIETER W (contact);POSSE, STEFAN

PROGRAM_OFFICER_NAME: AUBRECHT, TARYN GRACE

PROJECT_TERMS: Anesthesia procedures;Applications Grants;Area;Artificial Intelligence;awake;Brain;Brain imaging;Brain Mapping;Brain Neoplasms;Clinical;Complement;Computer Workstations;connectome;Consumption;cortex mapping;cost effective;Custom;data quality;Data Set;deep learning;Development;Edema;Equilibrium;Excision;experience;FDA approved;Feasibility Studies;Functional impairment;Functional Magnetic Resonance Imaging;Generations;Glioblastoma;Goals;Grant;Growth;Hair;health care service organization;high end computer;Human;Imaging technology;improved;Innovation Corps;International;Language;Lead;Legal patent;Magnetic Resonance Imaging;Manufacturer;Maps;Market Research;Marketing;Medial;meetings;member;minimally invasive;Monitor;Nervous System Physiology;neuroimaging;Neurologic;New Mexico;Operative Surgical Procedures;Patient Participation;patient population;Patients;Performance;Phase;Positron-Emission Tomography;Preparation;preservation;programs;prototype;Quality Control;Research;Rest;Scanning;Sensitivity and Specificity;Small Business Technology Transfer Research;Software Tools;Speed;success;System;Technology;technology development;technology validation;Testing;Time;Tissues;tool;tumor;Tumor Tissue

PROJECT_TITLE: Towards intra-operative guidance in brain tumor surgery using real-time resting-state functional MRI


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Violence Research;Youth Violence

ORG_NAME: NEW SCHOOL UNIVERSITY

PHR: Project Narrative  This Dissertation Award (R36 Substance Use/Substance Use Disorder Dissertation Research Award (R36 Clinical Trials Optional)) challenges existing conceptualizations of racism-related experiences through an innovative framework that includes historical and present-day dimensions. Historical trauma may intensify traumatic stress-related reactions in response to present-day racial discrimination for Black young adults and may provide critical insight into the observed disparities in polysubstance use risk beyond what a unidimensional approach of racial discrimination can provide. Lastly, the omission of historical trauma in research examining racial discrimination as a risk factor for polysubstance use presents a critical barrier for the development of novel, comprehensive culturally-relevant tools and interventions that effectively reduce polysubstance use in Black young adults.

PI_NAMEs: EBRAHIMI, CHANTEL TANNAZ (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: Accounting;addiction;Adult;age effect;Anger;Award;Biometry;Black Populations;Black race;career;Clinical Trials;Complex;Development;Diagnosis;Dimensions;Disparity;effective intervention;Enrollment;Ethnic Origin;ethnoracial minority;Evaluation;Event;experience;Factor Analysis;Goals;Grief reaction;Health;health disparity;health equity;Indigenous;Individual;innovation;insight;Institution;intergenerational;Intervention;K-Series Research Career Programs;lens;Link;Measures;Mediating;Mental disorders;Mental Health;Mentorship;Methods;microaggression;Minority Groups;Minority-Serving Institution;Modeling;mortality risk;National Institute of Drug Abuse;New York City;novel;overdose death;overdose risk;Participant;Pathway interactions;Persons;polysubstance use;Population;Post-Traumatic Stress Disorders;Prevention;Property;psychological symptom;Psychometrics;Questionnaires;Race;racial discrimination;racism;Reaction;recruit;Reduce health disparities;Research;Research Personnel;response;Risk;Risk Factors;rumination;Severities;social determinants;Strategic Planning;stressor;Students;substance use;Substance Use Disorder;Symptoms;Testing;tool;Trauma;trauma symptom;traumatic stress;Work;young adult;Youth

PROJECT_TITLE: Exploring Historical Trauma, Racial Discrimination, PTSD, and Substance Use Among Black Young Adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (20)]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Mental Illness;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prescription Drug Misuse;Prevention;Serious Mental Illness;Substance Misuse

ORG_CITY: PRINCETON

ORG_NAME: ZENA THERAPEUTICS INC.

ORG_STATE: NJ

PHR: Anxiety is highly prevalent in those with opiate use disorder, and is linked to earlier and more rapid progression, and high probability of co-use GABAA receptor positive modulators, such as benzodiazepines (BZDs), the current standard of care treatment for fast-acting relief of anxiety. BZDs are involved in an estimated 12,000 overdose fatalities each year in the US, largely due to the concomitant use with other CNS depressants, such as opioids. Our innovation is aimed at providing equally effective fast-acting treatments for anxiety that do not enhance opioid-induced respiratory depression to prevent overdose fatalities.

PI_NAMEs: CARRY, EILEEN  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, TAM L

PROJECT_TERMS: Anxiety;Anxiety Disorders;anxiety treatment;Benzodiazepines;Biological Availability;Central Nervous System Depressants;commercialization;comparative efficacy;Data;Development;effective therapy;Enrollment;Epidemic;Funding;high risk population;in vivo;Individual;innovation;Innovation Corps;Lead;Link;Marketing;nanomolar;novel;Opioid;opioid overdose;opioid use disorder;Oral;overdose death;Panic Disorder;parent grant;Pathway interactions;prevent;Probability;programs;receptor;Rodent Model;Series;Small Business Technology Transfer Research;standard of care;Testing;United States National Institutes of Health;Ventilatory Depression

PROJECT_TITLE: Development of compound RUEC2-118, a novel partial GABAAR positive modulator, a fast-acting treatment for general anxiety and panic disorder, to prevent opioid and benzodiazepine overdose fatalities.


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: 8. Project Narrative: Fusion oncoproteins act as the key drivers of cancer formation and progression in many forms of pediatric and adolescent cancer. Our team of investigators will develop novel small molecules that impair the function of critical fusion oncoproteins through two approaches: 1) identifying small molecules that target transcriptional regulatory complexes that are co-opted by fusion oncoproteins to induce oncogenic gene expression programs, and 2) developing small molecules that impair protein sequences required for self-association of intrinsically disordered regions that are essential to the oncogenic nature of many fusion oncoproteins.

PI_NAMEs: MCFADDEN, DAVID GLENN (contact);READY, JOSEPH M

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: addiction;Adolescent;Amino Acid Sequence;Amino Acids;Binding;Biochemical;Biochemistry;Biological Assay;cancer cell;CDC2 gene;Cell Line;Cells;Chemicals;Childhood;Chimeric Proteins;Complex;CRISPR screen;Cyclin-Dependent Kinase Inhibitor;Cyclin-Dependent Kinases;Development;Disease;DNA Binding Domain;Drug Design;drug discovery;Ewings sarcoma;EWSR1 gene;FLI1 gene;Fusion Oncogene Proteins;Gene Expression;Genetic;Genetic Transcription;genome-wide;Goals;high throughput screening;Impairment;inhibitor;innovation;lead optimization;Link;Malignant Childhood Neoplasm;Malignant Neoplasms;Maps;Mediating;Mediator;Methods;Molecular;mutant;Nature;novel;novel therapeutics;Oncogenic;Oncoproteins;pharmacologic;Phase;Phosphotransferases;Pre-Clinical Model;preclinical evaluation;preclinical study;programs;Protein Region;Protein-Serine-Threonine Kinases;Proteins;recruit;Research;Research Personnel;Rhabdomyosarcoma;Sarcoma;Serine;Signal Transduction;small molecule;small molecule inhibitor;Structure;targeted treatment;Transcription Coactivator;transcription factor;TRAP Complex;tumorigenesis;Vaccinia

PROJECT_TITLE: Targeting transcriptional addiction in fusion-driven sarcoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-P (M2)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE There is currently no therapy that can prevent the development of epilepsy after brain trauma. Here we propose to test the efficacy of a novel compound, and determine its efficacy and tolerability in an animal model of posttraumatic epilepsy, in a setting that resembles the clinical practice of care of people with severe traumatic brain injury. We also aim to identify and validate novel biomarkers that can predict who will develop epilepsy and who may respond to a treatment that can prevent epilepsy, in hope that this may accelerate and optimize future efforts to develop new antiepileptogenic therapies.

PI_NAMEs: AGOSTON, DENES V.;COLES, LISA D;DUNCAN, DOMINIQUE ;GALANOPOULOU, ARISTEA S (contact);MAZARATI, ANDREY M;O'BRIEN, TERENCE JOHN;STABA, RICHARD

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Acceleration;acquired epilepsy;Acute;Advisory Committees;Advocate;Anatomy;Animal Model;Anticonvulsants;Antiepileptogenic;Autophagocytosis;Axon;Bioinformatics;Biological Markers;biomarker discovery;biomarker identification;biomarker panel;biomarker selection;Blood;Blood Vessels;Brain;brain magnetic resonance imaging;Brain Pathology;Calcium-Binding Proteins;California;candidate marker;Caring;Cell Death;Cessation of life;Classification;Clinical;clinical practice;Collaborations;college;Corpus Callosum;Data;Deposition;design;Development;Discriminant Analysis;Disease;Double-Blind Method;early detection biomarkers;Early Post-Traumatic Seizures;Early treatment;efficacy testing;Electroencephalography;Epilepsy;Epileptogenesis;experience;External Capsule;fluid percussion injury;Free Radicals;functional outcomes;Funding;Future;Glial Fibrillary Acidic Protein;Guidelines;Health Services;Hemorrhage;High Frequency Oscillation;high standard;histological stains;HMGB1 gene;Image;improved;in vivo;Inflammatory;Injury;Interferon Type II;Interleukin-1 beta;International;Intervention;Investigation;Iron;Iron Chelation;Isoenzymes;Laboratories;Lateral;Learning;Levetiracetam;Link;Machine Learning;Magnetic Resonance Imaging;Medicine;Memory;Metabolic;Minnesota;Modeling;Modification;Molecular;Monitor;Motor;multimodality;National Institute of Neurological Disorders and Stroke;Neuroglia;neuroimaging;Neurons;novel;novel marker;Oxidative Stress;Pathologic;Pathology;Patients;Peripheral;Persons;pharmacokinetic model;Physiological;Plasma;Populations at Risk;Post-Traumatic Epilepsy;pre-clinical;Pre-Clinical Model;Preclinical Testing;predictive marker;Predictive Value;prevent;primary endpoint;Process;prophylactic;protein biomarkers;Randomized;Rattus;Recovery of Function;Research;Risk;Risk Factors;Seizures;Site;standard of care;synergism;tau Proteins;tau-1;Testing;Therapeutic;Time;Tissues;Translational Research;Traumatic Brain Injury;treatment response;ubiquitin C-terminal hydrolase;Universities;University Health Services;Visuospatial

PROJECT_TITLE: Translational Platform for Epilepsy Therapy and Biomarker Discovery


NIH_SPENDING_CATS: Biotechnology;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative Neurons relies on lysosomal activity to maintain homeostasis and its disruption results in an irreversible process called neurodegeneration. This project will define how the deficiency of the TBCK protein disrupts the levels of the JIP4 protein and how this disruption could result in impairments to the maturation and motility of lysosomes. Such studies are crucial to understand how the novel interaction and mechanism between TBCK and JIP4 influences lysosomal functionality in neurons, and how this mechanism can be translated to other disorders, such as lysosomal storage disorders.

PI_NAMEs: ORTIZ-GONZALEZ, XILMA R (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Address;Administrative Supplement;Affect;Age;Axon;Bioenergetics;Biological Assay;Cells;Child;Childhood;Complex;confocal imaging;Confocal Microscopy;Data;Defect;differential expression;Disease;Distal;Early Endosome;Endosomes;experimental study;Fibroblasts;Functional disorder;functional restoration;Goals;Homeostasis;Human;human induced pluripotent stem cells;Image;Impairment;indexing;Induced Neurons;induced pluripotent stem cell;insight;Integral Membrane Protein;Knowledge;late endosome;Lead;Link;Lysosomes;MAPK8 gene;Mediating;Membrane Potentials;Messenger RNA;Microfluidics;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Mitochondrial Proteins;Modeling;Morphology;Motility;mRNA Translation;Mutation;N-terminal;NADP;Nerve Degeneration;Neurodegenerative Disorders;neurodegenerative phenotype;Neurodevelopmental Disorder;neuronal cell body;Neurons;new therapeutic target;novel;Organelles;Oxygen Consumption;Patients;Peptide Synthesis;Phenotype;Phosphotransferases;Physiological;Plasmids;polypeptide;Population;Positioning Attribute;Predisposition;Process;Production;Protein Biosynthesis;protein complex;Protein Import;Protein Kinase;Protein Kinase Interaction;Proteins;Proteome;Proteomics;Proxy;Puerto Rican;Quality Control;Reporter;Reporting;respiratory;Ribosomes;RNA;Role;senescence;Severities;single molecule;stem;Stress;superoxide dismutase 1;Syndrome;Testing;Thiosulfate Sulfurtransferase;trafficking;Transcript;transcriptome;transcriptome sequencing;Translating;Translations;Variant;Visualization;Work

PROJECT_TITLE: Administrative Supplement for Unraveling the Mechanisms of Neurodegeneration in TBCK Encephaloneuronopathy

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Emergency Care;Health Services;Physical Injury - Accidents and Adverse Effects;Prevention;Screening and Brief Intervention for Substance Misuse;Social Determinants of Health;Substance Misuse

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative Globally, alcohol causes more than 3 million deaths and is a leading avoidable risk factor. Currently, in low-resource settings like Tanzania, alcohol-related treatment and resources are scarce and our team has created an effective brief intervention to reduce alcohol use among patients at Kilimanjaro Christian Medical Center. This program planning project will conduct a mixed method feasibility assessment and co-design final intervention, implementation strategy and trial design work products to implement this innovative intervention in the Northern Tanzania region.

PI_NAMEs: MMBAGA, BLANDINA THEOPHIL;STATON, CATHERINE ANN (contact)

PROGRAM_OFFICER_NAME: KWAKO, LAURA ELIZABETH

PROJECT_TERMS: Accident and Emergency department;Acute;addiction;Adoption;Agreement;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol related consequences;alcohol-related injury;Alcohols;Behavior;binge drinking;brief alcohol intervention;brief intervention;care seeking;Caring;Cessation of life;Clinical Trials;Clinical Trials Design;cost;cost effective;cost effectiveness;Data;Data Collection;design;Development;Dissemination and Implementation;drinking behavior;Effectiveness;effectiveness evaluation;Emergency Care;Emergency Situation;Enrollment;Evaluation;Event;evidence base;Evidence based intervention;Evidence based treatment;Funding;Future;Goals;Grant;Guidelines;Harm Reduction;hazardous drinking;Health;Health Policy;Healthcare;high risk;Hospitals;Hybrids;implementation design;implementation intervention;implementation strategy;implementation trial;improved;Injury;innovation;Intervention;Intervention Trial;K-Series Research Career Programs;low and middle-income countries;low income country;Mediation;Medical center;Mental Health;Methods;Modeling;modifiable risk;Motivation;National Institute on Alcohol Abuse and Alcoholism;Nature;Nurses;Patients;Persons;post intervention;Pragmatic clinical trial;pragmatic trial;Privatization;Process;programs;Protocols documentation;Public Health;Randomized;reduced alcohol use;Reporting;Research;Resource-limited setting;Resources;Risk;Risk Factors;Rural;Site;Tanzania;Technology;Text;Text Messaging;Training;treatment services;trial design;United States National Institutes of Health;Visit;Work

PROJECT_TITLE: PRICE- Alcohol: Planning the Regional Implementation of a Culturally Adapted Brief Intervention for Alcohol for Tanzanian Emergency Departments

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Palliative Care;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE PUBLIC HEALTH RELEVANCE: The proposed study is relevant to public health because it addresses the critical lack of psychosocial interventions adapted and studied in Latin America for Spanish-speaking Latinos diagnosed with advanced cancer. Meaning-Centered psychotherapy (MCP), a novel psychotherapeutic intervention designed to help patients with advanced cancer sustain or enhance a sense of meaning, and it will be tested in a type 1 hybrid randomized clinical trial with Spanish-speaking Mexican patient with advanced cancer treated at the National Mexican Cancer Institute.

PI_NAMEs: COSTAS-MUNIZ, ROSARIO  (contact);GALINDO VÁZQUEZ, OSCAR

PROGRAM_OFFICER_NAME: VEDHAM, VIDYA

PROJECT_TERMS: acceptability and feasibility;acronyms;Address;Advanced Malignant Neoplasm;Aftercare;Anxiety;anxiety symptoms;Brain;Cancer Center;Cancer Patient;Caring;Central American;Cessation of life;Clinical;clinical training;Cognitive Therapy;Collaborations;comparison control;depressive symptoms;Diagnosis;Disease;Dissemination and Implementation;dissemination science;Distress;efficacy evaluation;Emotional;end of life;Environment;evidence base;Feasibility Studies;Feeling hopeless;Fright;Funding;Future;Grant;Health Personnel;high risk;Hybrids;implementation design;implementation determinants;implementation framework;implementation intervention;implementation science;implementation strategy;improved;Individual;information gathering;Infrastructure;innovation;Institution;Institutional Review Boards;Intervention;intervention effect;Latin America;Latin American;Latino;Latino Population;Life;literacy;low and middle-income countries;Malignant Neoplasms;Mediating;Mediation;Mediator;member;Memorial Sloan-Kettering Cancer Center;Mental Depression;Mental disorders;Mental Health;Methods;Mexican;Mexico;Modeling;Mood Disorders;mood symptom;mortality;Nervous System Physiology;New York;novel;Oncology;oncology service;Outcome;Palliative Care;Patients;peace;Peer Review;Personal Satisfaction;physical symptom;Pilot Projects;Population;post intervention;Practical Robust Implementation and Sustainability Model;Prevalence;primary outcome;programs;Protocols documentation;Psychological Impact;Psychologist;psychosocial;Psychotherapy;Public Health;public health relevance;Quality of life;randomized, clinical trials;Research;Research Personnel;Research Project Grants;Research Training;Resources;Science;Scientist;secondary outcome;socioeconomics;Spanish;Spiritual well-being;Spirituality;Study of Latinos;Symptom Burden;Symptoms;Testing;therapy design;Training;Uncertainty;Writing

PROJECT_TITLE: Trial of Meaning Centered Psychotherapy for Mexican Patients with Advanced Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-L (55)]