NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Pulmonary embolism (PE) remains a leading cause of death in the United States. This project aims to develop a new ensemble deep learning model and train the model in a distributed fashion on multi-institutional data to automate the risk stratification of PE by integrating diagnostic computed tomography imaging with clinical electronic medical record data. This precision-medicine approach has the potential to rapidly and accurately perform PE risk assessment at the point of care, which could help reduce adverse clinical outcomes and increase our understanding of post-PE complications.

PI_NAMEs: LANGLOTZ, CURTIS P (contact);SHAH, NIGAM H

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Acute;Algorithms;Angiography;Anticoagulant therapy;Architecture;Biological Markers;Blood Vessels;breast imaging;Cardiogenic Shock;care delivery;Caring;Cause of Death;Chest imaging;chronic thromboembolic pulmonary hypertension;Clinical;clinical care;Clinical Data;clinical predictors;Code;Collaborations;Computational Technique;Computerized Medical Record;Computers;Computing Methodologies;Data;Data Analytics;data de-identification;data repository;Data Set;deep learning;deep learning model;demographics;design;Diagnosis;Diagnostic;Diagnostic Imaging;digital medicine;electronic structure;Engineering;Environment;Evaluation;Exhibits;experience;Fostering;Funding;Goals;Health Care Costs;health care quality;health data;Health Insurance Portability and Accountability Act;health record;Healthcare;Heart Arrest;Hemorrhage;heterogenous data;high risk;hospital readmission;Hospitals;Image;imaging biomarker;imaging study;improved;improved outcome;indexing;Individual;Information Systems;Institution;Laboratories;Learning;Lung;Medical Imaging;Medicine;Methods;Modeling;Morbidity - disease rate;mortality;mortality risk;Multicenter Studies;National Heart, Lung, and Blood Institute;neuroimaging;Outcome;Outcome Measure;outcome prediction;Outpatients;Pathology Report;patient safety;patient stratification;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;point of care;Population;precision medicine;predictive modeling;primary outcome;prognostic model;prospective;Pulmonary Embolism;Pulmonary Hypertension;radiological imaging;Radiology Specialty;Recurrence;Research;Resuscitation;Risk;Risk Assessment;risk stratification;Scanning;secondary outcome;Sensitivity and Specificity;Severities;Site;Source;Statistical Models;stem;Structure;Syndrome;System;Testing;Therapeutic;Time;Training;training data;United States;United States National Library of Medicine;unstructured clinical data;X-Ray Computed Tomography

PROJECT_TITLE: Population-level Pulmonary Embolism Outcome Prediction with Imaging and Clinical Data: A Multi-Center Study

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: EUGENE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: NARRATIVE This project will provide the first measurements of visual response properties and functional organization in the octopus visual system. This has the potential to reveal aspects of visual processing that are shared across diverse species, which would suggest fundamental computations that are broadly required for vision.

PI_NAMEs: NIELL, CRISTOPHER M (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Address;Adolescent;Anatomy;Animals;Area;Behavior;Body Patterning;Brain;Brain region;Calcium;Cells;Cephalopoda;Code;Color;Complex;Computer Analysis;detector;Drosophila genus;Encapsulated;Environment;Evolution;Eye;Face;fly;Functional Imaging;Image;image processing;Individual;insight;Invertebrates;Mammalian Cell;Mammals;Measurement;Measures;Mediating;Methods;Modality;model organism;Modeling;Motion;network models;neural;neural circuit;Neural Network Simulation;Neurons;novel;Octopus;Optic Lobe;orientation selectivity;Output;Partner in relationship;Pathway interactions;Population;Process;Property;receptive field;Research;response;Retina;Sensory;Structure;System;transmission process;two-photon;Vertebrates;Vision;Visual;visual coding;Visual Cortex;visual information;visual processing;visual stimulus;Visual System;Work

PROJECT_TITLE: Neural coding and functional organization of the octopus visual system


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Pediatric

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE The education and training of young MD and PhD researchers is the lifeblood of continued progress in medical care. This training grant fills a critical need by preparing these individuals to work at the cutting edge of biomedical research in gastrointestinal, liver, as well as their related nutritional diseases. By training young MD and PhD researchers side by side, this program also reinforces the importance of intellectual cross fertilization.

PI_NAMEs: BURRIN, DOUGLAS G (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Pediatrics;Research Training

PROJECT_TITLE: Research Training in Pediatrics Gastroenterolgy


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: SHREVEPORT

ORG_DEPT: PHYSIOLOGY

ORG_NAME: LOUISIANA STATE UNIV HSC SHREVEPORT

ORG_STATE: LA

PHR: R-loops are DNA:RNA hybrids that have been shown to play parts in normal cellular physiology and in disease states, and this project is designed to investigate a novel mechanism for the resolution of R-loop structures. The successful completion of this project will contribute to the fundamental knowledge of R-loop processing as part of eukaryotic cellular physiology as well as applications to human diseases such as neurologic disorders and cancer.

PI_NAMEs: MACKAY, RYAN PATRICK (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Amino Acids;anaplastic thyroid cancer;ATP phosphohydrolase;Basic Science;Benign;Binding;Binding Proteins;Biology;Biometry;Bromodeoxyuridine;cancer cell;Cancer cell line;Cancer Patient;Cell Death;Cell Physiology;Cells;Chromatin Loop;Clinical;Clinical Research;clinical training;Comet Assay;Complementary DNA;Complex;Conserved Sequence;Core Facility;Data;Data Analyses;data modeling;Deamination;Dedications;design;Development;Discipline;Disease;DNA;DNA Damage;DNA Double Strand Break;DNA fiber assay;DNA replication fork;DNA Structure;DNA-Directed RNA Polymerase;doctoral student;Educational process of instructing;Educational workshop;Enzymes;Evaluation;Exonuclease;experience;Experimental Designs;Faculty;Family;Focus Groups;Functional disorder;Gamma-H2AX;Gene Expression;Genetic Transcription;Genomic Instability;Goals;graduate school;Grant;Health Sciences;Healthcare;helicase;Human;human disease;Hybrids;Immunofluorescence Immunologic;Immunoglobulin Class Switching;Immunoglobulin Switch Recombination;improved;in silico;Institution;Instruction;interest;knock-down;Knowledge;Label;Laboratories;laboratory development;Link;Louisiana;Malignant Neoplasms;malignant neurologic neoplasms;mammalian genome;Measures;medical schools;medical specialties;meetings;Mentors;Messenger RNA;Methods;Mitochondria;mutant;nanomolar;Nervous System Disorder;Normal Cell;novel;nuclease;overexpression;Papillary thyroid carcinoma;Pathologic;Pharmaceutical Preparations;Physiologic pulse;Physiological Processes;Play;prevent;Prevention;Process;programs;Protein Overexpression;Proteins;Publications;Publishing;Recombinants;Replication Initiation;Research;Research Design;Research Personnel;Research Training;Residencies;Resolution;Resources;Review Literature;Ribonucleases;Ribonucleoproteins;RNA;RNA annealing;RNA Binding;RNA Interference;RNA Processing;RNA Splicing;Role;Sampling;Single-Stranded DNA;Site-Directed Mutagenesis;skills;small molecule;Small Nuclear Ribonucleoproteins;Statistical Data Interpretation;statistics;Structure;Students;Superhelical DNA;Techniques;Technology;Testing;Therapeutic;Thyroid Gland;Tissues;TOP2A gene;Topoisomerase;Training;Transcriptional Regulation;Universities;Western Blotting;Writing

PROJECT_TITLE: Investigating a novel role for Top2a in R-loop resolution and in YM155 mechanism of action


ADMINISTERING_IC: HS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The diagnostic process unfolds longitudinally across settings over time; diagnostic harm occurs with similar frequency in outpatient and in-patient settings along this journey. Communication failures underlying diagnostic errors suggests an opportunity for robust communication among teams and with children and families. Using S1 and S2 approaches, among children with multiple chronic conditions, we will characterize the diagnostic journey, focusing on patient/family-clinician communication, and adapt and test the impact of an outpatient structured family-centered communication intervention (PFC I-PASS) on diagnostic success, errors and harm.

PI_NAMEs: LANDRIGAN, CHRISTOPHER PAUL;WALSH, KATHLEEN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: HAUGSTETTER, MONIKA

PROJECT_TITLE: Re-engineering Patient and Family Communication to Improve Diagnostic Safety Resilience


ORG_CITY: MADISON

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PUBLIC HEALTH RELEVANCE/PROJECT NARRATIVE This proposal directly addresses the public health burden of the rising rates of significant falls in older adults which are the leading cause of traumatic morbidity and mortality in the elderly. Specifically, the use of an automated screening tool harnesses existing data resources and information systems to use the ED to better coordinate care between the ED and existing preventive resources in the health system. Beyond improving care for older adults with falls, this study will demonstrate the promise of using information technology to deliver public health interventions in the ED setting without diverting provider resources from the core ED mission of providing quality acute care.

PI_NAMEs: PATTERSON, BRIAN W (contact)

PROGRAM_OFFICER_NAME: SIMPSON, MATTHEW

PROJECT_TITLE: Preventing Future Falls in Older Adult ED Patients: Evaluating the Implementation and Effectiveness of a Novel Automated Screening and Referral Intervention

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_STATE: CA

PHR: PROJECT NARRATIVE Coordinated beating of the heart relies on specialized heart cells known as the cardiac conduction system (CCS). Damage to this system can result in a host of diseases including life-threatening arrhythmias. The proposed research will examine the mechanisms underlying CCS development and function, creating translational opportunities aimed at the prevention and treatment of cardiac rhythm disorders.

PI_NAMEs: GOODYER, WILLIAM R (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Accidents;Adult;Advisory Committees;Alleles;Animals;Antibodies;Area;Arrhythmia;Backcrossings;Basic Science;Biological;Biological Assay;Biological Pacemakers;Calcium;California;Cardiac;Cardiac conduction system;Cardiac Myocytes;Cardiac Output;Cardiac Surgery procedures;Cardiology;Cardiovascular system;career;Categories;Cell Count;Cell Physiology;Cell surface;Cell Surface Proteins;cell type;Cells;Childhood;Circulation;Clinical;Communication;copine;CRISPR/Cas technology;Development;diagnostic tool;Disease;Dose;Dyes;Echocardiography;Educational workshop;Electrocardiogram;Electrophysiology (science);Exercise;experience;experimental study;externship;Foundations;gain of function;Gene Expression Profile;Gene Expression Profiling;Generations;Genes;genome wide association study;Germ Lines;Goals;Grant;Harvest;Heart;heart cell;heart function;Heart Rate;heart rate variability;heart rhythm;Heterogeneity;Human;Human Development;human induced pluripotent stem cells;iatrogenic injury;Image;imaging modality;Immunofluorescence Immunologic;In Vitro;in vivo;in vivo evaluation;International;Intervention;Ion Channel;knock-down;Knock-out;Knockout Mice;Knowledge;Label;Leadership;Life;Link;loss of function;Measures;Medicine;Membrane;Mentors;Mentorship;Methods;Microscopy;mid-career faculty;Molecular;Molecular Analysis;Monitor;Mus;near infrared dye;new therapeutic target;nodal myocyte;novel;novel diagnostics;Operative Surgical Procedures;optical imaging;overexpression;Pediatrics;Phenotype;Physicians;Postdoctoral Fellow;prevent;Prevention;professor;programs;protein transport;Protocols documentation;Publishing;Reporter;Research;Resolution;Role;Safety;Science;Scientist;Signal Transduction;single-cell RNA sequencing;skills;Small Interfering RNA;Stem Cell Research;stem cells;Structure;System;Systems Development;targeted agent;Techniques;Time;Tissue-Specific Gene Expression;Tissues;trafficking;Training;Training Activity;training opportunity;Transgenic Organisms;translational barrier;translational medicine;translational potential;transmission process;Universities;Variant;Visualization;voltage;Work;Writing

PROJECT_TITLE: Elucidation of the Development and Function of the Cardiac Conduction System

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hypertension;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: NARRATIVE: Cardiovascular disease (CVD) is the leading cause of death globally, with 80% of the burden in low- and middle-income countries (LMICs), but little is known about CVD incidence rates and associated risk factors in these settings. Our study will provide the first population-based incidence estimates of CVD risk factors and adjudicated events including heart failure, stroke, ischemic disease, and cardiac death in Haiti, and we will identify modifiable factors that can be targets for future evidence-based CVD prevention. The proposed research is the critical next step towards fighting the CVD epidemic in LMICs and will provide global insights on CVD health disparities in the 21st century.

PI_NAMEs: MCNAIRY, MARGARET LEIGHTON (contact);PAPE, JEAN WILLIAM

PROGRAM_OFFICER_NAME: MASTERSON, MARY YAA SEDEGAH

PROJECT_TERMS: acronyms;Address;adjudication;Adult;Age of Onset;age stratification;Black Populations;Black race;Blood;blood pressure elevation;Cardiac Death;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular risk factor;Cause of Death;Cessation of life;cohort;contextual factors;Country;Data;design;Development;Diabetes Mellitus;dietary salt;Disease;Enrollment;Epidemic;epidemiologic data;Event;evidence base;Evidence based intervention;fighting;follow-up;food insecurity;Future;future implementation;Goals;Grant;Guidelines;Haiti;Haitian;Health;health disparity;Heart;Heart failure;high risk;high salt diet;Hyperlipidemia;Hypertension;hypertension control;implementation strategy;improved;Incidence;Income;Individual;Infection;Inflammation;insight;Intervention;Interview;Ischemia;Kidney Diseases;Knowledge;Lead;lead exposure;Life Cycle Stages;Longitudinal cohort study;low and middle-income countries;Mental Depression;Methods;Modeling;modifiable risk;mortality;Myocardial Infarction;Obesity;Persons;physical inactivity;Policies;Population;Population Attributable Risks;population based;population health;Positioning Attribute;Poverty;premature;preservation;pressure;Prevalence;prevent;Prevention;recruit;Research;Risk;Risk Factors;Risk Marker;Risk Reduction;Role;Sample Size;Secure;sex;Smoking;social;social determinants;Social isolation;social organization;Stress;Stroke;Subgroup;success;Surveys;Target Populations;Training;Transient Ischemic Attack;Unhealthy Diet;United States National Institutes of Health;violence exposure;Woman;young adult

PROJECT_TITLE: A longitudinal cohort study to evaluate cardiovascular risk factors and disease in Haiti - 2

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials and Supportive Activities;Emphysema;HIV/AIDS;Lung;Patient Safety

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Emphysema is a common serious co-morbidity in people living with HIV (PLWH). We will study if doxycycline slows its progression in PLWH (current or former smokers) by measuring diffusing capacity (how well oxygen transfers from air into blood) and quantifying computed tomography (CT) scans of the lungs. We will evaluate if doxycycline improves health status with patient-oriented surveys and functional status with 6 minute walk tests in a multi-center, randomized, placebo-controlled trial.

PI_NAMEs: SPINO, CATHERINE A (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Acceleration;Achievement;Adherence;Adverse event;Age of Onset;Air;Antibiotics;archived data;barometric pressure;Biomedical Research;Biometry;Blood;Budgets;Carbon Monoxide;Carboxyhemoglobin;Case Report Form;Cause of Death;Chronic Obstructive Pulmonary Disease;Clinical;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Data Monitoring Committees;Collaborations;Collection;Communication;comorbidity;comparison control;Computer software;Custom;Data;Data Collection;Data Coordinating Center;data management;Data Set;database design;Databases;design;Diffusion;Disease Progression;Documentation;double-blind placebo controlled trial;Doxycycline;education research;Ensure;Esapent;experience;Faculty;FDA approved;Feasibility Studies;former smoker;Fostering;functional status;Funding;General Population;Goals;Health Status;Hemoglobin;HIV;improved;Incidence;Individual;Information Dissemination;Infrastructure;innovation;Interstitial Lung Diseases;Investigation;Leadership;Lung Diseases;lung imaging;Matrix Metalloproteinase Inhibitor;Matrix Metalloproteinases;Measures;Medicine;meetings;Methodology;Michigan;Monitor;multidisciplinary;National Heart, Lung, and Blood Institute;Online Systems;operation;Outcome;Oxygen;Participant;patient oriented;Persons;Pharmaceutical Preparations;Phase;Phase II Clinical Trials;Pilot Projects;Play;Population;Prevalence;primary endpoint;Procedures;Process;Productivity;programs;Protocols documentation;Provider;Pulmonary Emphysema;Pulmonology;Qualifying;Randomized;randomized placebo controlled trial;Recording of previous events;Reporting;Reproducibility;Reproducibility of Results;Research;Research Design;Research Personnel;Risk;Role;Safety;safety testing;Sample Size;Science;Scleroderma;Secure;Services;Slide;Smoking Status;software development;Statistical Data Interpretation;Statistical Methods;success;Surveys;System;targeted treatment;Teleconferences;Testing;Time;timeline;tool;Training;treatment duration;United States National Institutes of Health;Universities;Walking;web site;webinar;X-Ray Computed Tomography

PROJECT_TITLE: 2/2 Doxycycline for Emphysema in People Living with HIV: The DEPTH Trial

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(JA)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Women's Health Research

ORG_CITY: WALTHAM

ORG_NAME: BRANDEIS UNIVERSITY

PHR: Project Narrative (Public Health Significance) There is little research on the intersection of race, ethnicity, physical disability, and maternal and infant outcomes. The proposed study will investigate pregnancy complications and outcomes among Black women and Latinas with physical disabilities by analyzing existing state and national data from a variety of sources, conducting qualitative interviews with Black women and Latinas who have given birth, and conducting focus groups with obstetric care providers. This study will examine disparities in care and create and disseminate practice recommendations to improve perinatal care for Black women and Latinas with physical disabilities.

PI_NAMEs: HORNER-JOHNSON, WILLI ;MITRA, MONIKA  (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: 1 year old;Achievement;Address;adverse birth outcomes;Adverse event;adverse outcome;adverse pregnancy outcome;Affect;Apgar Score;Birth;black women;California;care costs;care providers;Cesarean section;Characteristics;cost;Data;Development;Disabilities experience;disability;Disability outcome;Disability status;Disabled Persons;Discipline of obstetrics;Discrimination;Disparity;Emergency Situation;ethnic minority;Ethnic Origin;experience;Focus Groups;Foundations;Future;Gestational Diabetes;Goals;Health;Health Care Costs;health care disparity;health care service utilization;health data;health service use;Healthcare;Hospitals;improved;improved outcome;Infant;Infant Health;infant outcome;Inpatients;Intervention;Interview;Knowledge;Latina;Latina Population;Link;marginalization;Massachusetts;maternal outcome;Methods;Monitor;Mothers;National Health Services;obstetric care;Outcome;outcome disparities;Perinatal;Perinatal Care;perinatal health;physically handicapped;poor health outcome;post pregnancy;postpartum care;Pre-Eclampsia;Pregnancy;Pregnancy Complications;pregnancy health;pregnancy hypertension;Pregnancy Outcome;pregnant;Premature Infant;prenatal;Prenatal care;Provider;Public Health;Race;racial minority;Recommendation;Reproductive Health;Research;Research Personnel;Risk;Risk Assessment;Small for Gestational Age Infant;social stigma;Source;System;Testing;White Women;Woman;Women's cohort;women's outcomes

PROJECT_TITLE: Disparities in Perinatal Care and Outcomes among Black Women and Latinas with Physical Disabilities

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biotechnology;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CAMBRIDGE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: We will apply synthetic biology and advanced control theory techniques to genetically program human induced pluripotent stem cells (hiPSCs) that generate vascularized pancreatic organoids suitable for endocrine/exocrine and other developmental studies. Our engineered genetic circuits embedded in hiPSCs will regulate multi-step differentiation of these hiPSCs into desired population ratios of the multiple lineages comprising complex pancreatic organoid structures. Our proposed research represents a departure from current in vitro organoid synthesis protocols and will usher in a fresh perspective on organogenesis that will be germane to the precise synthesis of any organoid, as well as to other feedback regulated multi-cellular systems.

PI_NAMEs: WEISS, RON  (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: 3-Dimensional;Address;Adult;Affect;Biological;Cell Lineage;cell type;Cells;Chemicals;Complex;control theory;design;Development;Developmental Biology;developmental plasticity;DIF factor;Ectopic Expression;Endocrine;Endoderm;Endoderm Cell;Endoribonucleases;Engineering;Exhibits;Feedback;Fibroblasts;Functional disorder;Gene Expression Profile;Genes;Genetic;Genetic Engineering;Growth Factor;Hepatic;human induced pluripotent stem cells;In Vitro;in vivo;Individual;innovation;Investigation;Liver;Manuals;Measures;Mesoderm;Methods;Modeling;novel;Organ;Organogenesis;Organoids;Output;Pancreas;pancreas development;Patients;Physiology;Population;Population Control;Production;progenitor;programs;Protocols documentation;ratiometric;recombinase;Regulation;Reproducibility;Research;sensor;Signal Transduction;single-cell RNA sequencing;small molecule;Specific qualifier value;stem cell biology;stem cell differentiation;Structure;synthetic biology;System;Techniques;Tissues;transcription factor;Vascularization;Work

PROJECT_TITLE: Genetically Programmed Pancreatic Organoids with Self-Adaptive Multi-Lineage Population Control

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Hypertension;Infectious Diseases;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE During the initial SARS CoV-2 (COVID-19) outbreak in the first half of 2020, epicenter areas such as New York City were particularly hard hit and traditional ambulatory care ceased entirely for several months. Older adults with multiple chronic conditions were not only at high risk for poor health outcomes due to COVID-19 infection, but also disruption of ambulatory care for this vulnerable population may have resulted in meaningful short and longer-term impacts on cardiovascular health. This study leverages two large electronic health record networks to measure the impact of care disruptions on cardiovascular health and health disparities following the acute pandemic shutdown.

PI_NAMEs: DODSON, JOHN A (contact);THORPE, LORNA

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Academic Medical Centers;Acute;acute COVID-19;Acute myocardial infarction;Adopted;Adoption;Adult;Age;aged;Ambulatory Care;Area;Biometry;Blood Pressure;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;care delivery;Caring;Categories;Cessation of life;Chronic;Chronic Disease;Clinical;Clinical Research;COVID-19;COVID-19 impact;COVID-19 outbreak;COVID-19 pandemic;Data;data modeling;Data Science;Diabetes Mellitus;Disasters;Disease Outcome;Disparity;disparity reduction;Dyslipidemias;economic disparity;Economically Deprived Population;Economics;Electronic Health Record;Epidemiology;ethnic minority;Ethnic Origin;Event;experience;Future;Gerontology;Glycosylated hemoglobin A;Health;health care delivery;health care service;health care service utilization;Health Disparities Research;health disparity;health disparity populations;health inequalities;Health system;Healthcare;Healthcare Systems;Heart Arrest;Heart failure;high risk;Hospitals;Hypertension;implementation science;improved;Institution;Ischemic Stroke;Joints;Left;Long-Term Effects;Longitudinal Studies;Measures;Mediation;Medical;medical schools;Medicine;Methods;Minority Groups;minority patient;Modeling;multidisciplinary;multilevel analysis;multiple chronic conditions;New York City;Obesity;older adult;Outcome;pandemic disease;pandemic disruption;patient population;Patients;Pattern;Persons;Phase;Policies;poor health outcome;Population;Positioning Attribute;Private Hospitals;Public Hospitals;Race;racial minority;Readiness;Research;Resources;Risk;SARS-CoV-2 infection;sex;social vulnerability;socioeconomic disadvantage;Source;Standardization;Subgroup;System;Telemedicine;Translations;Unstable angina;uptake;Visit;Vulnerable Populations;women patients

PROJECT_TITLE: COVID-19 shutdown: impact of healthcare disruptions on cardiovascular health disparities among people with multiple chronic conditions in New York City.


ORG_CITY: Chicago

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Cesarean delivery, when overused, is harmful to women and newborns, and raises healthcare costs without appreciable benefit; yet, despite significant efforts to reduce overuse, persistent and scalable improvement has been elusive. Organizational culture change strategies have been successful in improving outcomes in other areas of healthcare, but tend to receive little attention in statewide cesarean reduction initiatives as evidence- based tools to facilitate change are lacking. This proposal seeks to use rigorous user-centered design and implementation science principles to develop a “Culture Change Toolset” to target the most upstream causes of L&D units’ failure to adopt and sustain change in cesarean delivery rates.

PI_NAMEs: WHITE VANGOMPEL, EMILY  (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Supporting Vaginal Birth in Illinois: the Role of Unit Culture

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Neurodegenerative;Neurosciences;Opioids;Pain Research;Peripheral Neuropathy;Social Determinants of Health;Telehealth

ORG_CITY: BURLINGTON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: PROJECT NARRATIVE This innovative study utilizes a technology based novel care model to provide timely care to cancer survivors with CIPN in their time of greatest need and strives to improve quality of life while reducing disability and opiate use. It seeks to fill an important gap in knowledge about CIPN care using consensus based guidelines without time consuming face to face encounters. The study has broad potential impact and relevance as this care model can be integrated into health systems encouraging telemedicine, in particular rural or resource poor areas with reduced healthcare access.

PI_NAMEs: KOLB, NOAH ALLAN (contact);MOONEY, KATHLEEN H;SMITH, A. GORDON

PROGRAM_OFFICER_NAME: STRECK, BRENNAN PARMELEE

PROJECT_TERMS: Accidents;active method;Aftercare;Algorithms;Callback;cancer survival;Cancer Survivor;Caring;chemotherapy;Chemotherapy-induced peripheral neuropathy;comparison control;Consensus;Consumption;Data;Dependence;Diagnosis;disability;Disability Evaluation;Disabling;Dose;efficacy evaluation;Emerging Technologies;European Organization for Research and Treatment of Cancer;evidence base;fall risk;FDA approved;follow-up;foot;Fright;Gait;Goals;Guidelines;Hand;health care availability;Health Care Costs;health related quality of life;Health Services Accessibility;Health system;high risk;Home;Hybrids;improved;Individual;innovation;Internet;Intervention;Knowledge;Life;Malignant Neoplasms;Measures;Mediation;mobile application;Modality;Modeling;Monitor;Morbidity - disease rate;Neuropathy;neurotoxic;new technology;novel;Nurse Practitioners;Nurses;Office Visits;Online Systems;Opioid;opioid epidemic;opioid mortality;opioid use;Outcome;Pain;painful neuropathy;Participant;Patients;personalized care;Pharmaceutical Preparations;Physicians;prescription opioid;prevent;Preventive treatment;prospective;Prospective Studies;Protocols documentation;Publishing;Quality of life;Randomized;Recommendation;remote monitoring;Reporting;Resource-limited setting;response;Risk;Running;Rural;secondary outcome;Self Care;Sensory;side effect;Signs and Symptoms;standard care;standardize guidelines;Substance abuse problem;symptom management;symptomatic improvement;Symptoms;System;Technology;Telemedicine;Telephone;telephone based;Time;Titrations;tool;treatment as usual;treatment duration;Visit;web site;Withholding Treatment

PROJECT_TITLE: Remote Monitoring of Management of Chemotherapy induced Peripheral Neuropathy

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Women's Health Research

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: In this proposal, we use an interdisciplinary approach and combine experimental and computational methods to investigate the emergence and role of reactive stroma in ductal carcinoma in situ progression to the invasive tumor. The long-term goal of our work is to identify factors that induce stromal reactivity associated with progression from DCIS to invasive tumors that may be used as a biomarker in the clinic.

PI_NAMEs: DAMAGHI, MEHDI ;REJNIAK, KATARZYNA ANNA (contact)

PROGRAM_OFFICER_NAME: MILLER, DAVID J

PROJECT_TERMS: 3-Dimensional;Acidosis;Algorithms;Basement membrane;Biological Markers;Biomechanics;Breast Cancer Cell;Breast Cancer Model;breast cancer progression;Breast Carcinogenesis;cancer care;cancer cell;cell stroma;Cells;Cellular Morphology;Classification;Clinic;Clinical;Clinical Data;cohort;Collagen Fibril;Complex;Computer Models;computerized tools;Computing Methodologies;Data;Data Analyses;Desmoplastic;Development;Duct (organ) structure;ductal breast carcinoma;Ecosystem;Environment;Epithelial Cells;Experimental Models;experimental study;Extracellular Matrix;Fatty acid glycerol esters;Future;Gene Expression;Generations;Genetically Engineered Mouse;Genotype;Goals;Heterogeneity;histological specimens;Histology;Hypoxia;Image;Image Analysis;immunohistochemical markers;improved;in silico;In Vitro;in vivo;infiltrating duct carcinoma;interdisciplinary approach;intravital imaging;Invaded;Investigation;Lesion;Malignant Breast Neoplasm;mammary;Mammary Duct;mathematical model;Medical Imaging;Metabolic;Metabolism;Modeling;models and simulation;Molecular;Monitor;multidisciplinary;Mutation;neoplastic;neoplastic cell;non-genetic;Noninfiltrating Intraductal Carcinoma;normoxia;novel;Organoids;Oxygen;Pathologist;Patients;Penetration;Preventive;Process;Prognostic Factor;Proliferating;Regulation;Research Personnel;Role;role model;Signal Transduction;spatiotemporal;Specialist;Specimen;Stomas;Stromal Cells;Structure;Testing;Therapeutic;Tissue Banks;Tissues;tumor;Tumor Cell Invasion;tumor microenvironment;Tumor-Derived;Variant;Work

PROJECT_TITLE: Modeling the role and regulation of reactive stroma in breast ductal carcinoma microinvasions

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine;Women's Health Research

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Genetic and epigenetic complexities expand during tumor progression and complicate the clinical management of cancer. Similarly, the incidence of bone metastasis increases in advanced stages of cancer (> 50% rate). Our study will deepen our understanding of epigenetic-driven intra-metastasis heterogeneity in breast cancer and reveal novel therapeutic approaches to overcome resistant metastases.

PI_NAMEs: BADO, IGOR LANDRY (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: 3-Dimensional;Address;Advanced Malignant Neoplasm;Advisory Committees;Advocate;Affect;Anemia;anti-cancer research;Bar Codes;bone;Bone Matrix;Brain;Breast;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Model;Calcium;Calcium Signaling;cancer cell;cancer diagnosis;Cancer Etiology;cancer subtypes;Career Mobility;Cell Survival;Cells;Cessation of life;Chromatin;Clinical Management;Clinical Trials;clinically relevant;Coculture Techniques;college;Coma;Complex;Comprehensive Cancer Center;conventional therapy;Data;DNA methylation profiling;DNA Sequence Alteration;Endocrine;epigenetic drug;Epigenetic Process;epigenomics;epithelial to mesenchymal transition;Epithelium;Estrogen receptor positive;Estrogen Receptors;Estrogens;Evolution;exome sequencing;EZH2 gene;FDA approved;FGF2 gene;FGFR1 gene;Fibroblast Growth Factor;Fostering;Gap Junctions;Genetic;Genetic Heterogeneity;Genetic Transcription;Genomics;Goals;Growth;Growth Factor;Heterogeneity;Hypercalcemia;in vivo evaluation;Incidence;Individual;inflammatory breast cancer;Inherited;Institution;International;laser capture microdissection;Lesion;Libraries;Liver;Lung;Malignant Breast Neoplasm;Malignant Neoplasms;mammary gland development;Maps;Mediating;Medicine;Mentors;Metastatic Neoplasm to the Bone;Micrometastasis;Molecular;multiple omics;Mutation;Neoplasm Metastasis;non-genomic;novel;novel therapeutic intervention;Numbness;Oncologist;Organ;osteoblast differentiation;Osteoblasts;Osteoclasts;overexpression;Pain;Paralysed;parathyroid hormone-related protein;Pathological fracture;Patients;Perfusion;Phase;Phenotype;Platelet-Derived Growth Factor;Positioning Attribute;Process;professor;Proteomics;public health relevance;receptor expression;Receptor Protein-Tyrosine Kinases;Recurrence;Research;Resistance;Resources;Scientist;Senior Scientist;Signal Pathway;Signal Transduction;single cell analysis;single cell ATAC-seq;single-cell RNA sequencing;Site;Spatial Distribution;stemness;System;Techniques;Technology;Testing;Therapeutic;therapy resistant;Tissue Microarray;trait;TRANCE protein;transcriptomics;Transforming Growth Factor beta;treatment response;tumor;tumor growth;tumor heterogeneity;tumor progression;Validation;Variant

PROJECT_TITLE: Tracing and targeting the epigenetic heterogeneity in breast cancer metastasis

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SEATTLE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Schizophrenia is a genetic, neurodevelopmental disorder. In this project, I will use CRISPR-based technologies in induced pluripotent stem cells to examine how severe genetic mutations associated with schizophrenia disrupt gene expression and neurobiology. Findings from these experiments will improve our understanding of these cellular phenotypes of schizophrenia and may lead to new prognostic, diagnostic and treatment approaches.

PI_NAMEs: SUNSHINE, ANNA BROSIUS (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Award;Biological Assay;Biology;Blood;Brain;career development;Case/Control Studies;Cell Line;Cell model;cell motility;Chromatin;chromatin remodeling;Clinic;Clinical;Clinical Data;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Complex;Consent;CRISPR correction;CRISPR interference;CRISPR/Cas technology;Defect;Development;Diagnostic;Disease;disease phenotype;DNA;DNA Sequence Alteration;Enrollment;Epigenetic Process;established cell line;exome;exome sequencing;experimental study;Functional disorder;Future;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic association;Genetic Heterogeneity;genetic variant;Genomics;Genotype;Goals;improved;In Vitro;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Institutional Review Boards;knock-down;Laboratory Study;Lead;Learning;Lesion;lymphoblast;Measures;Mediating;Mentorship;Modeling;Molecular;mutant;Mutation;Neurites;Neurobiology;Neurodevelopmental Disorder;Neuronal Differentiation;Neurons;NR4A2 gene;Oxidative Stress;Parents;Participant;participant enrollment;Pathogenesis;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Persons;Phenotype;Point Mutation;proband;prognostic;Program Development;rare variant;recruit;repaired;Reproducibility;Research;Resources;RNA;Schizophrenia;skills;stem cell model;synaptic function;Therapeutic;Training;Transcriptional Regulation;transcriptome;transcriptome sequencing;transcriptomics;Variant

PROJECT_TITLE: Modeling patient mutations in iPSC-derived neurons to reveal cellular mechanisms of schizophrenia


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE The proposed research is relevant to the NIH because it is focused on fundamental biology that will impact cardiovascular disease and potentially develop a new therapeutic paradigm to treat and prevent sudden cardiac death; many heart disease states result in abnormal trafficking of proteins in the heart muscle cells. Abnormal protein trafficking is related to sudden death, but there are no therapies that address this trafficking defect. We propose to use a protein called GJA1-20k that we have shown improved trafficking of certain proteins to recover this trafficking defect in a mouse heart disease model.

PI_NAMEs: PALATINUS, JOSEPH A. (contact)

PROJECT_TERMS: Actins;Address;Affect;Age;Animal Model;Arrhythmia;arrhythmogenic cardiomyopathy;Biology;Birth;Cardiac Myocytes;cardioprotection;Cardiovascular Diseases;Cardiovascular system;career development;Cell Culture Techniques;Cell model;Cessation of life;Cicatrix;Co-Immunoprecipitations;Confocal Microscopy;Connexin 43;Connexins;Coronary;Coupling;Data;Defect;Defibrillators;desmoglein 2;Desmosomes;Devices;Disease;disease model;Doctor of Philosophy;Echocardiography;Educational workshop;effective therapy;Electron Microscopy;experience;Gap Junctions;Goals;Heart;Heart Diseases;Hela Cells;implantation;improved;in vivo;insight;Intercalated disc;International;Ion Channel;Ischemia;knock-down;Knock-out;Knowledge;Laboratories;Ligation;Link;Location;Mediating;medical schools;Mentors;Metabolic;Mitochondria;Modeling;Molecular;Monitor;Mus;mutant;Mutant Strains Mice;Mutation;Myocardial;Myocardial dysfunction;Names;new therapeutic target;Normal Statistical Distribution;novel;novel therapeutic intervention;novel therapeutics;Outcome;Oxygen;Pathologic;Patients;Persons;Phenotype;Physical activity;Physicians;preservation;prevent;Prevention;professor;Protein Isoforms;protein transport;Proteins;Recovery;Regulation;Reproducibility;Research;Research Personnel;Resolution;Robin bird;Role;Scientist;Signal Transduction;sudden cardiac death;Sudden Death;symposium;Targeted Research;targeted treatment;Techniques;Telemetry;Testing;trafficking;Training;Training Programs;Transfection;Translating;Translational Research;United States;United States National Institutes of Health;Universities;Utah;Virus;Vocational Guidance;Work

PROJECT_TITLE: Targeting Protein Trafficking in Arrhythmogenic Cardiomyopathy


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dietary Supplements;Heart Disease;Kidney Disease;Nutrition

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE This K-24 application will support sub-studies which will expand the scope of an NIH-funded randomized clinical trial evaluating thiamine (vitamin B1) as a medicinal intervention to improve the exceedingly low survival rate and high incidence of injury to other organs after out-of-hospital sudden cardiac arrest. The proposed sub-studies will specifically establish if thiamine prevents post-arrest kidney injury and provide new insight into the impact of thiamine on other key components of metabolism. The K-24 application will simultaneously provide support for an accomplished investigator/mentor in maintaining a much-needed junior investigator mentoring program in resuscitation science.

PI_NAMEs: DONNINO, MICHAEL WILLIAM (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Acetyl Coenzyme A;Acute;Acute Renal Failure with Renal Papillary Necrosis;Address;adverse outcome;Aerobic;Animal Model;Animals;Award;Biological Markers;Blood;Brain;Brain Injuries;Career Mobility;Cause of Death;Cell Respiration;Cerebrum;Cessation of life;Citric Acid Cycle;Clinical;Clinical assessments;Clinical Trials Design;cofactor;Creatinine;Critical Illness;Data;Dependence;Depressed mood;Dialysis procedure;Enzymes;experience;experimental study;Frustration;Funding;Future;glucose metabolism;Glutathione S-Transferase P;Glycolysis;Goals;Heart;Heart Arrest;Human;Impairment;improved;In Vitro;Incidence;Injury;Injury to Kidney;insight;Intervention;Intravenous;Ischemic Brain Injury;K-Series Research Career Programs;Ketoglutarate Dehydrogenase Complex;Kidney;Kidney Diseases;Kidney Failure;Laboratories;Lactic Acidosis;LCN2 gene;Link;Measurement;Measures;Mediator;Medicine;Mentors;Metabolic;Metabolism;Mitochondria;Morbidity - disease rate;mortality;Nervous System Trauma;neuroprotection;Neuroprotective Agents;next generation;Organ;organ injury;out-of-hospital cardiac arrest;Outcome;Oxygen Consumption;Parents;patient oriented;Patients;Pattern;Peripheral Blood Mononuclear Cell;Persons;placebo group;Placebos;post gamma-globulins;Prevalence;prevent;primary outcome;Production;Productivity;programs;Property;protective effect;Publications;Pyruvate;pyruvate dehydrogenase;randomized trial;randomized, clinical trials;rat KIM-1 protein;Reaction;Renal function;Research;Research Infrastructure;Research Personnel;Resuscitation;Sampling;Science;Scientist;Sepsis;Septic Shock;Survival Rate;synergism;System;Testing;Thiamine;Thiamine Deficiency;Thioctic Acid;Time;Training Programs;Translational Research;treatment group;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Thaimine as an adjunct metabolic resuscitator in cardiac arrest

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cervical Cancer;Immunization;Immunotherapy;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: PATHOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative This proposal is designed to support Dr. Shiwen Peng, a dedicated Research Specialist and essential member of the Cervical Cancer Research Lab at the Johns Hopkins University School of Medicine. In particular, this application is intended to support his efforts to develop vaccines and novel immunotherapeutic strategies for the prevention and treatment of human papillomavirus (HPV)-associated diseases. Towards the activities of the CCRL, Dr. Peng will utilize standard immunological laboratory techniques to develop novel preclinical tumor models and human immunological assays, which are intended to facilitate collaboration with clinical investigators for translation to the clinical care setting and human clinical trials.

PI_NAMEs: PENG, SHIWEN  (contact)

PROGRAM_OFFICER_NAME: BASA JANAKIRAM, NAVEENA

PROJECT_TERMS: anti-cancer research;Applications Grants;Cancer Biology;cancer immunotherapy;Cancer Patient;clinical care;Clinical Investigator;clinical translation;Clinical Trials;Collaborations;Data;Dedications;design;Development;Disease;DNA Vaccines;experience;experimental study;Foundations;gene gun;Generations;Goals;Human;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16;Immunologics;Immunology;Immunology procedure;Immunotherapeutic agent;Immunotherapy;improved;in vivo;innovation;innovative technologies;Knowledge;Laboratories;Malignant neoplasm of cervix uteri;malignant oropharynx neoplasm;medical schools;member;Modeling;novel;novel strategies;novel vaccines;Patients;Peer Review;pre-clinical;Prevention;Prevention strategy;programs;Proteins;Publications;Research;Research Personnel;Role;skills;Specialist;success;symposium;Techniques;Testing;Training;translation to humans;Translational Research;translational scientist;tumor;Universities;vaccination strategy;vaccine candidate;vaccine development;vaccine evaluation;Work

PROJECT_TITLE: Development and Characterization of Immunotherapies for HPV-Associated Malignancies


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Maternal Health;Nutrition;Pediatric;Prevention;Women's Health Research

ORG_DEPT: PHARMACOLOGY

PHR: NARRATIVE At present, methods to predict transporter-mediated milk secretion of drugs and drug PK in human breast milk do not exist. We propose a systems pharmacology approach to address this significant knowledge gap. Such studies are important for rational risk assessment of drug exposure to breastfeeding infants.

PI_NAMEs: HEBERT, MARY F (contact);WANG, JOANNE

PROGRAM_OFFICER_NAME: SAMEDY BATES, LESLY

PROJECT_TERMS: ABCG2 gene;absorption;Address;Breast Epithelial Cells;Breast Feeding;Breastfed infant;Cell membrane;Cell Separation;Characteristics;Cimetidine;Clinical;Clinical Research;Confidence Intervals;Consumption;CYP3A4 gene;Data;design;Diffusion;Dose;Drug Exposure;Drug Kinetics;Drug toxicity;Drug usage;enzyme activity;Enzymes;Excretory function;Exposure to;falls;Goals;Health;Human;Human Milk;in silico;In Vitro;in vivo;Individual;Infant;infant outcome;innovation;interest;Knowledge;Lactation;mammary;Mammary gland;Maternal Health;Mediating;Methods;Midazolam;Milk;milk secretion;Modeling;models and simulation;Mus;neonatal health;Oral;Pharmaceutical Preparations;pharmacokinetic model;Pharmacology;Physiological;physiologically based pharmacokinetics;Plasma;Play;Population;Postpartum Period;predictive modeling;Pregnancy;Property;Proteins;Proteomics;Regimen;Riboflavin;Risk;Risk Assessment;Role;rosuvastatin;statistics;System;Topotecan;Toxic effect;Transfection;Translating;Vesicle;Wild Type Mouse;Woman;Xenobiotics

PROJECT_TITLE: PBPK Modeling & Simulation to Predict Transporter-Mediated Drug Secretion into Human Breast Milk

STUDY_SECTION: DBDT

STUDY_SECTION_NAME: Drug and Biologic Disposition and Toxicity Study Section[DBDT]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Hematology;Human Genome;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative We propose to determine how MYC initiates and maintains tumorigenesis. We have generated a library of conditional transgenic mouse models for MYC-driven cancer and human PDX models that we will use to identify novel vulnerabilities in MYC-driven cancers through RNAseq, ChIPseq and DESI-MSI, CRISPR synthetic lethal screens and MYC function reporter systems. Our collaborative research proposal will identify novel therapeutic targets for MYC driven cancer.

PI_NAMEs: FELSHER, DEAN W (contact)

PROGRAM_OFFICER_NAME: GHOSH-JANJIGIAN, SHARMISTHA

PROJECT_TERMS: Acute;Adenocarcinoma Cell;anti-cancer research;bcr-abl Fusion Proteins;Biological Models;cancer therapy;carcinogenesis;Cells;ChIP-seq;Clustered Regularly Interspaced Short Palindromic Repeats;Exhibits;Genes;Glean;Goals;Human;Immune;In Vitro;in vivo;innovation;insight;leukemia;Libraries;lipid biosynthesis;Lung Adenocarcinoma;Lymphoma;Malignant Neoplasms;metabolomics;Methods;Modeling;Molecular;mouse model;MYC gene;new technology;new therapeutic target;novel;novel therapeutics;nucleocytoplasmic transport;Oncogenes;Osteosarcoma;Pathway interactions;patient derived xenograft model;Primary carcinoma of the liver cells;Productivity;programs;Renal Cell Carcinoma;Reporter;Research;Research Personnel;Research Proposals;RNA;Role;Seminal;System;T-Lymphocyte;Tetracyclines;transcriptome sequencing;Transgenic Mice;tumor;tumorigenesis;Work

PROJECT_TITLE: Targeting the MYC Pathway for the Treatment of Cancer


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: Baltimore

ORG_NAME: AGENEBIO, INC.

PHR: The GABA-A α5 Positive Allosteric Modulator (PAM) program represents a novel approach to Mild Cognitive Impairment due to Alzheimer’s Disease (MCI due to AD), a patient population at high risk for dementia and, as such, would address a critical unmet need that will otherwise significantly burden patients, caregivers and the healthcare system in the decades ahead. With no current treatments for this indication, it is critical that novel Discovery and Development Programs, such as the one described in this application, advance novel chemical entities (NCEs) at therapeutically relevant targets as rapidly as possible. The GABA-A α5 PAM program benefits from clinical and regulatory paths in place for MCI due to AD along with appropriate mechanistic and therapeutic biomarkers making this a program that can advance the goals of the National Plan to Address Alzheimer’s Disease.

PI_NAMEs: PAYIE, KENNETH G (contact)

PROGRAM_OFFICER_NAME: REFOLO, LORENZO

PROJECT_TERMS: Acute;Address;Adult;Advanced Development;age related;Age-associated memory impairment;Alzheimer's Disease;Alzheimer's disease model;Amendment;anti-epileptic agents;Area;brain dysfunction;Canis familiaris;Caregivers;Chemicals;Chronic;Clinical;clinical development;Clinical Protocols;Clinical Research;Coupled;Cyclic GMP;dementia risk;Dosage Forms;Dose;Dose Limiting;Dryness;Elderly;Formulation;gamma-Aminobutyric Acid;Goals;Half-Life;Healthcare Systems;high risk;Hippocampus;Human;improved;In Vitro;in vivo;Levetiracetam;manufacture;medial temporal lobe;Memory;Memory Loss;Methods;mild cognitive impairment;Modeling;Monitor;Monkeys;neuronal circuitry;Neurons;novel;novel strategies;Oral;Pathology;patient population;Patients;Performance;Pharmaceutical Preparations;Pharmacology;Phase;phase 1 study;Phase I Clinical Trials;positive allosteric modulator;pre-clinical;pre-Investigational New Drug meeting;preclinical study;Preparation;Process;product development;Program Development;programs;Protocols documentation;Published Comment;Rattus;receptor;Research;Rodent;Role;Safety;safety study;scale up;Therapeutic;therapeutic biomarker;Toxic effect;Toxicology;Treatment Efficacy;volunteer

PROJECT_TITLE: Preclinical and early clinical development of a GABA-A a5 PAM


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Social Determinants of Health

ORG_CITY: IOWA CITY

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE It is well-known that sex (e.g., male, female) matters for medical and mental health outcomes, and that some genetic contributions to health and disease depend on sex. But gender is not the same things as sex, so we developed a questionnaire that describes a person's gender identity, allowing us to investigate how gender influences genetic factors in determining health outcomes. This research will provide value to gender minority groups by seeking a better understanding of how genetic risk and resilience applies specifically to them, and not just the cisgender proportional majority.

PI_NAMEs: MICHAELSON, JACOB JAMES (contact);STRANG, JOHN

PROGRAM_OFFICER_NAME: RIVERS, ROBERT C

PROJECT_TERMS: Address;Adult;Age;autism spectrum disorder;Biomedical Research;Birth;Calibration;Cardiometabolic Disease;Categories;cisgender;clinical care;clinical risk;cognitive performance;Collaborations;Communities;community based participatory approach;community partners;community partnership;Complex;Data;Descriptor;Developmental Disabilities;Dimensions;Discipline;Disease;Disparity;Dissociation;Eating Disorders;Education;Emotional;Equity;Ethics;Exclusion;experience;Female;Gender;gender diverse;gender diversity;Gender Identity;gender minority;gender minority community;gender minority group;gender minority health research;Genetic;Genetic Research;Genetic Risk;Genomics;Genotype;Grant;Health;Heterogeneity;Immune System Diseases;Individual;insight;instrument;Language;Laws;Leadership;Letters;male;Measures;Medical;member;Mental Health;method development;Methods;Minority Groups;Modeling;Nature;nonbinary;novel;novel strategies;Outcome;Patient Self-Report;Pattern;personalized medicine;Persons;Policies;Process;Psyche structure;Psychometrics;Questionnaires;Race;recruit;Research;Research Activity;resilience;resilience factor;Risk;Risk Assessment;Risk Factors;Sampling;Scientist;sex;Societies;Subgroup;suicidal;suicidal risk;Testing;tool;trait;transgender;United States National Institutes of Health;Vocation;Work;Writing

PROJECT_TITLE: A novel approach for equitable characterization of gender and its use in exposing subgroup discrepancies in polygenic score associations


NIH_SPENDING_CATS: Microbiome

ORG_CITY: HERSHEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: Project Narrative We have harnessed the glycan detection machinery possessed by members of the human gut microbiome to develop a new toolkit to complement current glycomics approaches. We demonstrate how these tools can be implemented to surveille crude biological samples for structurally diverse plant, animal, and microbial glycans and subsequently measure the relative abundance of individual substrates present in heterogenous glycan mixtures. Finally, we propose expand the capacity, specificity, and sensitivity of these tools to develop new affinity purification methods that can rapidly isolate individual glycans from a mixture for downstream structural analysis.

PI_NAMEs: TOWNSEND, GUY EDMUND (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Affinity;Affinity Chromatography;Animals;Automobile Driving;Bacteroides;Bacteroides thetaiotaomicron;Binding Proteins;Biological;biological preparation;Biological Process;Carbohydrates;clinically relevant;Complement;Complex;Complex Mixtures;cost;Detection;detection method;detection platform;Disease;Dose;Engineering;Environment;Gene Modified;Genes;Goals;gut bacteria;gut microbes;gut microbiome;gut microbiota;Harvest;health determinants;Human;In Vitro;Individual;interest;Intestinal Content;Intestines;Libraries;Life;Mass Spectrum Analysis;Measurement;Measures;member;Metabolic;Metabolism;Methods;Microbe;microbial;microbiome composition;Modeling;Modification;Natural regeneration;novel;Nuclear Magnetic Resonance;Nucleic Acids;Nutrient;Oligonucleotides;Organism;Output;Plants;Polymers;Polysaccharides;predictive tools;Proteins;Recombinants;Reporter;Reporting;Resources;response;Sampling;Sensitivity and Specificity;Source;Specificity;Standardization;Structure;Surveys;System;Therapeutic;therapeutic target;tool;tool development

PROJECT_TITLE: Harnessing the gut microbiome to detect and quantify glycans

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Prevention;Substance Misuse;Underage Drinking

ORG_CITY: CHAPEL HILL

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PUBLIC HEALTH RELEVANCE STATEMENT High-intensity drinking (HID; consuming 8+/10+ drinks in a row for females/males) is a highly consequential form of excessive alcohol consumption. The proposed study will develop and pilot test a just-in-time adaptive intervention to address risk factors for HID within the drinking context (e.g. social setting of the drinking episode). Findings will directly inform public health practice by documenting the impact of delivering strategies to reduce HID in the time and place they are needed most.

PI_NAMEs: COX, MELISSA JEAN (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: 21 year old;acceptability and feasibility;Acute;adaptive intervention;Address;Age;Alcohol abuse;alcohol availability;alcohol consequences;Alcohol consumption;Alcohol dependence;alcohol measurement;alcohol misuse;Area;Award;behavior change;Behavioral;binge drinking;career;Characteristics;Consumption;contextual factors;Data;design;Development;drinking;Ecological momentary assessment;Ecology;effectiveness evaluation;Elements;Event;experience;Experimental Designs;Female;Focus Groups;follow-up;Funding;Goals;hands on research;Harm Reduction;Health;Health behavior change;Heavy Drinking;high intensity drinking;High Prevalence;high risk;Individual;innovation;Intervention;Interview;Intoxication;K-Series Research Career Programs;Life;Location;male;meetings;Mentors;Mentorship;mhealth interventions;National Institute on Alcohol Abuse and Alcoholism;novel;Outcome;peer;pilot test;Population;prevent;Prevention;Prevention strategy;preventive intervention;psychologic;Public Health Practice;public health relevance;Randomized;randomized, clinical trials;Research;Research Personnel;Research Priority;Risk;Risk Factors;Sampling;Scientist;severe injury;skills;smartphone application;social;Social Environment;Specific qualifier value;Structure;Surveys;Taxonomy;Techniques;Testing;Time;time interval;Training;Training Activity;treatment strategy;United States National Institutes of Health;uptake;usability;Work;young adult;young adult alcohol use

PROJECT_TITLE: Development of a Just-in-Time Adaptive Intervention to Reduce High-Intensity Drinking among Young Adults

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE: Wnt signaling is essential for numerous tumor-types and may play an essential role in the development of aggressive thyroid cancers. In this proposal, I will study the role of Wnt signaling in aggressive thyroid cancer using next generation sequencing, novel thyroid cancer organoids, and a patient-derived xenograft mouse model to discover a potential new therapy for anaplastic thyroid carcinoma.

PI_NAMEs: WEISS, VIVIAN LEE (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Affect;American Cancer Society;anaplastic thyroid cancer;Automobile Driving;Award;beta catenin;Biology;BRAF gene;cancer cell;cancer diagnosis;cancer subtypes;Cell Line;Clinical Trials;cohort;Colorectal Cancer;Combined Modality Therapy;Copy Number Polymorphism;Data;Detection;Development;Disease;Disease Resistance;driver mutation;Effectiveness;Evaluation;Evolution;exome sequencing;experience;Failure;FDA approved;Foundations;Funding;Gene Expression;genetic makeup;Genetic Transcription;Goals;Grant;Growth;improved;in vivo;Incidence;inhibitor;inhibitor therapy;Knowledge;Light;Link;Malignant neoplasm of thyroid;Malignant Neoplasms;malignant phenotype;Mediating;Medical;MEKs;Mentors;Methylation;Modeling;Molecular;mouse model;Mus;mutant;Mutation;Neoplasm Metastasis;next generation sequencing;novel;novel therapeutics;Oncogenic;Organoids;Papillary thyroid carcinoma;Pathogenesis;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;Physicians;Play;pre-clinical;preclinical study;programs;Proliferating;Recurrence;Recurrent disease;refractory cancer;Reporter Genes;Research;Research Personnel;Resistance;resistance mechanism;Resources;Role;Sampling;Scientist;Signal Transduction;standard of care;System;Testing;Thyroid carcinoma;Thyroid Gland;thyroid neoplasm;transcriptome sequencing;tumor;Up-Regulation;WNT Signaling Pathway;Woman;Work

PROJECT_TITLE: The role of Wnt signaling in aggressive thyroid carcinoma

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Colorectal Cancer;Data Science;Digestive Diseases;Infectious Diseases;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative The proposed research project will develop principled and accessible statistical frameworks toward improved and more transparent capture-recapture (C-R) methods for effective use of multiple overlapping data streams for disease surveillance. A key goal of the project is an appropriate merging of statistical with epidemiologic design and implementation principles, to fully harness the power of C-R for enhanced validity and precision in the estimation of case counts while adjusting for false positive signals. These developments draw on current surveillance initiatives and provide immediate applications to improve estimates of breast and colorectal cancer recurrence totals over defined follow-up periods among patients in US-based cancer registries.

PI_NAMEs: LYLES, ROBERT H (contact);WALLER, LANCE A

PROGRAM_OFFICER_NAME: MARIOTTO, ANGELA B

PROJECT_TERMS: Address;Affect;analytical method;Attention;Automobile Driving;Breast;Breast Cancer Patient;burden of chronic illness;cancer recurrence;Cardiovascular Diseases;Cessation of life;Characteristics;Chronic Disease;Code;Colorectal;Colorectal Cancer;Communicable Diseases;comparative;Computer software;Data;Data Sources;data streams;data visualization;design;Development;Diagnostic;Disease;disease registry;Disease Surveillance;Ensure;Epidemiologic Monitoring;Epidemiologist;Epidemiology;flexibility;follow-up;Funding;Future;Goals;HIV Infections;HIV/HCV;improved;Individual;Intuition;Log-Linear Models;Malignant Breast Neoplasm;Malignant Neoplasms;Manufacturer;Medical Records;Methodology;Methods;Modeling;Monitor;Monitoring for Recurrence;mortality;Motivation;multiple data sources;neoplasm registry;novel;pathogen;Pathway interactions;patient registry;Patients;Performance;Population;Predictive Value;Prevalence;Property;Protocols documentation;Recurrence;Registries;Reproducibility;Research Design;Research Personnel;Research Project Grants;Sampling;Sensitivity and Specificity;Signal Transduction;simulation;Specific qualifier value;Statistical Methods;Stream;surveillance data;Surveillance Program;surveillance study;System;Techniques;theories;tool;Training;Tuberculosis;Uncertainty;Validation;Viral

PROJECT_TITLE: Refined Capture-Recapture Methods for Surveilling Cancer Recurrence

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Dissemination and Implementation Research;Genetic Testing;Genetics;Ovarian Cancer;Pancreatic Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE The goal of this project is to develop, evaluate, and implement a new electronic decision aid tool for individuals referred for genetic testing for an inherited cancer syndrome. We propose that such a decision aid can facilitate quality decisions around genetic testing, reduce the dependence upon formal genetic counseling, and improve access to genetic testing. The tools will be evaluated broadly in both academic and community oncology clinics at multiple institutions.

PI_NAMEs: CHUNG, DANIEL C (contact)

PROGRAM_OFFICER_NAME: BURNETT, ANDREA NICOLE

PROJECT_TERMS: acceptability and feasibility;Address;cancer care;Cancer Patient;Clinic;Clinical;Communication;Community Clinical Oncology Program;Complex;Conflict (Psychology);Consensus;Decision Aid;Decision Making;Dependence;Development;Diagnosis;Education;effectiveness evaluation;effectiveness/implementation study;efficacy evaluation;Electronics;gene panel;Genes;Genetic Counseling;genetic counselor;genetic panel test;genetic testing;Goals;Hereditary Neoplastic Syndromes;Human Resources;implementation outcomes;Improve Access;Individual;Inherited;innovation;Institution;Intention;Knowledge;Level of Evidence;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Medical Oncologist;Oncologist;Outcome;pancreatic cancer patients;Pathogenicity;patient population;Patients;Performance;Population Heterogeneity;preference;Procedures;Process;Productivity;Professional counselor;Provider;randomized trial;randomized, clinical trials;Research Design;Resources;Risk;satisfaction;shared decision making;standard of care;Syndrome;targeted treatment;Test Result;Testing;Time;tool;tumor;Update;uptake;Variant

PROJECT_TITLE: Development and Implementation of ElectronicDecision Aids for Genetic Testing in Inherited Cancer Syndromes


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Kidney Disease;Patient Safety;Pediatric;Prevention;Rare Diseases

ORG_CITY: CALGARY

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY OF CALGARY

ORG_STATE: AB

ORG_ZIPCODE: T2N 1N4

PHR: Project Narrative Shiga toxin-producing E. coli (STEC) infection is the most common cause of acquired kidney failure in children, causing acute, life-threatening complications and long-term disabilities. Although no treatment exists to date, preliminary studies have shown that early high volume intravenous fluid administration (hyperhydration) may be effective in mitigating or preventing complications. If effective, the results from this study will change clinical practice and improve the health of children by decreasing the acute morbidity and long-term complications associated with STEC infection and by providing epidemiologic, clinical, and biological data to improve our understanding and ability to combat this disease.

PI_NAMEs: FREEDMAN, STEPHEN BRADLEY (contact);SCHNADOWER, DAVID ;TARR, PHILLIP I

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: 5 year old;absorption;Accident and Emergency department;Acute;Acute Kidney Failure;Acute Renal Failure with Renal Papillary Necrosis;Adverse event;adverse event monitoring;Ambulatory Care;Antibiotics;Azotemia;Binding;biobank;Biological;Blood;Blood Vessels;Blood Volume;Canada;Caring;Centers for Disease Control and Prevention (U.S.);Cessation of life;Child;Child Health;Chronic Kidney Failure;Clinical;clinical care;Clinical Data;clinical practice;Cohort Studies;combat;Complication;Cross-Over Trials;Data;Dehydration;design;Diabetes Mellitus;Diagnosis;Diagnostic;Diarrhea;Disease;effectiveness evaluation;Enrollment;Enteral;Epidemiology;Escherichia coli EHEC;Escherichia coli Infections;Etiology;Event;Evidence based treatment;experience;Extravasation;Feces;Fluid overload;Grant;Hematocrit procedure;Hemolytic Anemia;Hemolytic-Uremic Syndrome;high risk;Hypertension;Implementation readiness;improved;improved outcome;Infection;Injury to Kidney;insight;Intervention;Intervention Trial;IV Fluid;Kidney;Kidney Failure;Life;Link;Liquid substance;Long term disability;long-term sequelae;Mediating;Medical;Meta-Analysis;Metagenomics;Molecular;Morbidity - disease rate;mortality;Motility;Narcotics;National Institute of Allergy and Infectious Disease;Non-Steroidal Anti-Inflammatory Agents;observational cohort study;open label;Outcome;outcome prediction;pathogen genomics;Patients;Phenotype;predictive marker;Prevalence;prevent;Prognostic Marker;Proteomics;Protocols documentation;Proxy;Random Allocation;Randomized;randomized trial;renal damage;Renal function;Renal Replacement Therapy;Research;Risk;Safety;Secondary to;Serious Adverse Event;Severities;Shiga Toxin;Site;Survivors;targeted biomarker;Technology;Testing;Therapeutic;therapeutic target;Thrombocytopenia;thrombotic;Time;transcriptomics;Treatment Protocols;United States;Urine;vascular injury;Work

PROJECT_TITLE: Hyperhydration to Improve Kidney Outcomes in Children with Shiga Toxin-Producing E. Coli Infection (HIKO STEC): A Multinational, Embedded, Cluster, Crossover, Randomized Trial


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Prevention;Rare Diseases;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Squamous cell carcinoma of the head and neck (HNSCC) comprises malignancies arising mainly from the mucosal surface of the oral cavity, pharynx, and larynx. It is a devastating, frequently disfiguring, and often fatal disease, which is expected to affect more than 53,000 people in the U.S. in 2020 and kill more than 10,000. This project will establish a profile analysis of DNA damage in oral cells of cigarette smokers and alcohol drinkers and relate this to the presence of HNSCC so that the profile can be used to identify those individuals who are at high risk for this terrible disease.

PI_NAMEs: HECHT, STEPHEN S (contact);KHARIWALA, SAMIR S

PROGRAM_OFFICER_NAME: WANG, WENDY

PROJECT_TERMS: Acrolein;adduct;Adult;Affect;Alcohol consumption;Alcoholic beverage heavy drinker;Alcoholic Beverages;Alcohols;analytical method;Cancer Etiology;carcinogenicity;Carcinogens;Cells;Characteristics;cigarette smoke;Cigarette Smoker;cigarette smoking;Collecting Cell;comparison group;Data;Disease;DNA;DNA Adducts;DNA analysis;DNA Damage;DNA Structure;Early Diagnosis;Electrospray Ionization;Genes;Goals;Growth;Head and Neck Squamous Cell Carcinoma;Heavy Drinking;high risk;Human;Human Papillomavirus;Incidence;indexing;Individual;Intervention;Larynx;Life Style;Light;Lipid Peroxidation;Malignant Neoplasms;Measurement;Methodology;Methods;Monitor;Mucous Membrane;Mutation;Names;nano-liquid chromatography;non-smoker;Operative Surgical Procedures;Oral;Oral cavity;Oral Examination;Patients;Pattern;Persons;Pharyngeal structure;Predisposition;prevent;Prevention;problem drinker;Process;recruit;Research;Resolution;Risk;Sampling;Smoker;Smoking;smoking cessation;Source;statistics;Surface;tandem mass spectrometry;Testing;Time;Tissues;Tobacco;toxicant;tumor

PROJECT_TITLE: High resolution mass spectrometric profile analysis of carcinogen-DNA adducts in oral cells of cigarette smokers and squamous cell carcinoma of the head and neck

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Suicide;Suicide Prevention;Telehealth

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative Depression and suicide are among the leading causes of disability and mortality, respectively, and prevalence rates for both have been increasing over the past three decades in the United States. Depression, suicidal ideation, and suicide attempts are especially prominent among young adults. This project seeks to develop a low-burden adaptive mobile intervention in which personalized feedback, informed by ecological momentary assessments and mobile/wearable technology data, can be delivered optimally and prevent the negative progression of mood symptoms into depressive episodes and suicidal behavior.

PI_NAMEs: HORWITZ, ADAM GABRIEL (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: acceptability and feasibility;adaptive intervention;Alcohol consumption;American;Applied Research;Awareness;barrier to care;Behavioral;career;Caring;Cause of Death;Cellular Phone;clinically significant;Collection;college;community based participatory research;coping;Counseling;Data;depressive symptoms;design;disability;disabling disease;Early Intervention;Ecological momentary assessment;Effectiveness;efficacy study;Emotional;Enrollment;Evaluation;Evidence based treatment;experience;Feedback;Feeling suicidal;follow-up;Future;Health Services Accessibility;Health Technology;heart rate variability;High Prevalence;Impairment;improved outcome;Individual;Intervention;Intervention Trial;Interview;Investigation;K-Series Research Career Programs;machine learning method;Mental Depression;Mental Health Services;Mentors;Mentorship;mHealth;mhealth interventions;mobile computing;mobile delivery;Mood Disorders;mood symptom;Moods;mortality;Names;Outcome;Participant;patient oriented research;Perception;Performance;Persons;Pharmaceutical Preparations;Physical activity;physical conditioning;Populations at Risk;preference;Prevalence;prevent;Preventive;preventive intervention;programs;Psychotherapy;Randomized;randomized trial;Reporting;Research;Research Methodology;Resources;response;Risk;risk mitigation;sensor;skills;Sleep;smart watch;Social Functioning;Statistical Data Interpretation;stressor;Structure;Students;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Surveys;Symptoms;Target Populations;Technology;therapy design;therapy development;Time;tool;Training;Transcript;United States;United States National Institutes of Health;university student;Waiting Lists;wearable device;wearable sensor technology;Work;young adult

PROJECT_TITLE: Low-burden Adaptive Mobile Interventions for Mood and Suicide Risk

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Digestive Diseases;Health Services;Infectious Diseases;Prevention;Rare Diseases;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: NEW YORK

PHR: PROJECT NARRATIVE Anal cancer incidence is rapidly rising in women and preventive measures such as screening have received little study in this group. Therefore, we will conduct a prospective, longitudinal study evaluating screening modalities for anal cancer precursors women with a history of lower genital tract neoplasia or cancer to determine the performance and acceptability of different screening tests and strategies as well as define the natural history of disease. These data will be used to inform a decision analysis to assess the overall benefits, harms and costs of screening.

PI_NAMEs: CHIAO, ELIZABETH Y.;DESHMUKH, ASHISH A.;SIGEL, KEITH MAGNUS (contact)

PROGRAM_OFFICER_NAME: SAHASRABUDDHE, VIKRANT V

PROJECT_TERMS: Acceleration;age group;Age Years;aged;Anal carcinoma;Anus;Biological Markers;Biopsy;Cancer Etiology;cancer prevention;cancer site;Carcinoma;Cervical;Characteristics;Clinical;Clinical Trials;comparative;cost;cost effective;cost effectiveness;Cytology;Data;Death Rate;Decision Analysis;Development;Disease;disease natural history;Dysplasia;Effectiveness;Epidemiology;evidence based guidelines;experience;Exposure to;Generations;Goals;Guidelines;Healthcare;high risk population;high standard;Histologic;HIV;HPV-High Risk;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papillomavirus;improved;Incidence;Lesion;Longitudinal Studies;longitudinal, prospective study;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;Malignant neoplasm of vulva;Malignant Neoplasms;Malignant Squamous Cell Neoplasm;mathematical model;Mathematics;Methods;Modality;Modeling;Morbidity - disease rate;mortality;multidisciplinary;Natural History;Neoplasms;Oncogenic;patient-level barriers;Patients;Performance;Persons;Population;premalignant;Prevalence;prevent;Prevention;Prevention Guidelines;prevention practice;Preventive measure;Provider;Publishing;Recommendation;Recording of previous events;Registries;Reporting;reproductive tract;Resolution;Resources;Risk;screening;Screening for cancer;screening guidelines;Sensitivity and Specificity;simulation;Site;Squamous cell carcinoma;Squamous intraepithelial lesion;Testing;Vaccines;Vagina;Vulva;Woman

PROJECT_TITLE: The effectiveness of screening women with lower genital tract neoplasia or cancers for anal cancer precursors

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE This application studies a new class of oncogenic mutations that affect the structure and function of histone proteins that complex with DNA to form chromatin. We will determine how these mutations cooperate with oncogenes that cause aberrant signaling and mutant chromatin regulators to drive malignancy, tumor heterogeneity and therapy resistance.

PI_NAMEs: LICHT, JONATHAN D. (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: Address;Affect;Amino Acids;Animal Model;Automobile Driving;Biochemical;Biological Assay;Bladder;BRAF gene;Breast Epithelial Cells;cancer genome;cancer genomics;Cancer Patient;Catalytic Domain;cBioPortal;CDKN2A gene;cell growth;cell immortalization;Cell model;cell transformation;Cells;Childhood Glioma;Chromatin;Chromatin Modeling;chromatin modification;Chromatin Structure;Collaborations;Colorectal Neoplasms;CRISPR/Cas technology;Data;Development;dimer;DNA;DNA Binding;DNA Damage;Dominant-Negative Mutation;Engineering;Enzymes;Epigenetic Process;epigenomic profiling;epigenomics;Gene Activation;Gene Expression;Gene Mutation;gene repression;gene therapy;Genes;genetic regulatory protein;Genetic Transcription;genome sequencing;genome-wide analysis;genomic data;Glutamic Acid;Goals;Head and neck structure;Heterogeneity;Histone Fold;Histone H2A;Histone H2B;histone methyltransferase;Histones;Human;In Vitro;Incidence;inhibitor;Intervention;Knock-in;KRAS2 gene;Lesion;Lung;lung carcinogenesis;Lysine;Malignant neoplasm of lung;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mediating;mouse model;Movement;mutant;Mutate;Mutation;neoplastic cell;novel;Nucleosomes;Oncogene Deregulation;Oncogenes;Oncogenic;oncohistone;Oncoproteins;Paper;Pathogenesis;Pathway interactions;Patients;Phosphatidylinositol 4,5-Diphosphate;Phosphotransferases;PIK3CA gene;prevent;Process;protein complex;Proteins;Publications;Recurrence;Repression;Resistance;Role;Signal Transduction;Signaling Molecule;Site;Structure;System;Tail;targeted treatment;Technology;Testing;Tobacco;TP53 gene;transcription factor;Transcription Initiation;treatment response;tumor;tumor heterogeneity;tumor progression;Tumor Suppressor Proteins;tumorigenesis;virtual;Xenograft Model;Yeasts

PROJECT_TITLE: Histone fold Mutations in Cancer Pathogenesis

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Services;Hypertension;Infectious Diseases;Prevention

ORG_CITY: PARKTOWN

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: WITS HEALTH CONSORTIUM (PTY), LTD

PHR: NARRATIVE People living with HIV around the world have longer lives and are increasingly being diagnosed with hypertension and diabetes which increases their risk for heart disease and stroke. Although there are established guidelines for hypertension and diabetes care, in South Africa, where nearly five million people are receiving treatment for HIV, patients, providers, and health care facilities have not been equipped to address the added challenges of managing these co-morbidities. Our team has strong partnerships with and experiences of supporting clinics and other stakeholders in South Africa to identify new ways of delivering care that overcomes these challenges and addresses patients’ HIV and heart disease risk factors together; in this proposal, we will adapt, implement, and evaluate a package of these proven interventions to improve hypertension and diabetes care within HIV clinics in South Africa and see if they are appropriate and used by clinics and their staff over a 3 year period in a large project in South Africa.

PI_NAMEs: ALI, MOHAMMED KUMAIL;MARCONI, VINCENT CHARLES;VENTER, FRANCOIS  (contact)

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: Address;Administrator;Adopted;Adoption;Adult;African;antiretroviral therapy;Award;Awareness;behavior change;Blood Glucose;Blood Glucose Self-Monitoring;Blood Pressure;budget impact;burden of illness;Cardiac health;Cardiovascular Diseases;cardiovascular disorder risk;care delivery;Caring;Clinic;Clinical;cluster trial;Collaborations;Communities;comorbidity;cost;cost estimate;Country;design;Detection;Diabetes Mellitus;Diagnosis;Disease;Doctor of Philosophy;Documentation;Effectiveness;effectiveness evaluation;Ethics;Event;Evidence based intervention;experience;Feedback;glucose monitor;Goals;Government;Guidelines;Health care facility;heart disease risk;HIV;HIV Seronegativity;Home;Human;human centered design;Human Resources;hybrid type 2 design;Hypertension;hypertension control;hypertension treatment;implementation research;implementation science;implementation strategy;implementation/effectiveness;improved;India;innovation;Institution;International;Intervention;intervention cost;Knowledge;Maintenance;Measurement;Measures;meetings;Mentorship;Meta-Analysis;Methods;Modeling;Modification;Monitor;Morbidity - disease rate;mortality;Motivation;multidisciplinary;National Heart, Lung, and Blood Institute;next generation;Output;Ownership;pandemic disease;patient-level barriers;Patients;Persons;Phase;Preparation;primary outcome;programs;Protocols documentation;Provider;provider-level barriers;Public Sector;Publications;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Recommendation;Research;Research Methodology;Research Personnel;Resources;response;Review Literature;Risk;Risk Assessment;Risk Factors;Risk Reduction;Rural;rural health clinic;scale up;Scientist;screening;Self Management;Site;South Africa;Stroke;Structure;success;support tools;System;system-level barriers;Testing;tool;Training;treatment strategy;Work

PROJECT_TITLE: Integrating HIV and hEART health in South Africa (iHeart-SA)


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Data Science;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

PHR: Project Narrative Lung cancer continues to be the leading cause of cancer-related deaths in both men and women in the United States, accounting for over 140,000 deaths per year (nearly one quarter of all cancer deaths). Bronchoscopy is currently the safest, least invasive, and least expensive diagnostic option, but yields conclusive results only 50-60% of the time, forcing many patients to consider more invasive procedures or leading to delayed diagnoses. We propose to develop computer algorithms that address localization limitations with existing bronchoscopes to improve diagnostic yield and achieve earlier lung cancer diagnosis in more patients.

PI_NAMEs: FRIED, INBAR  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: 3-Dimensional;3D Print;Accounting;Address;Algorithms;Anatomy;Area;Biopsy;Bronchoscopes;Bronchoscopy;cancer diagnosis;Cancer Etiology;career;Cessation of life;chest computed tomography;Clinical;Clinical Skills;Complication;Computational algorithm;computer science;Computer Simulation;Computer Vision Systems;Coupled;Data;Data Set;data-driven model;deep neural network;Devices;Diagnosis;Diagnostic;Diameter;Disease;Distal;Drops;Early Diagnosis;Electromagnetics;Ensure;Environment;Equipment;experience;experimental study;Family suidae;follow-up;Freedom;Frequencies;Future;Health Benefit;Hour;Human;improved;in vivo;Individual;laboratory experiment;large datasets;Lesion;Localized Disease;Localized Lesion;Location;Lung;lung cancer screening;lung lesion;Machine Learning;machine learning model;Malignant neoplasm of lung;Malignant Neoplasms;Measurement;Medical;Medicine;men;Mentors;millimeter;minimally invasive;Minor;Modeling;Morbidity - disease rate;mortality;Motion;Needles;Neoplasm Metastasis;Neural Network Simulation;Nodule;North Carolina;Operative Surgical Procedures;Patient observation;Patients;Physicians;Positioning Attribute;Preparation;Procedures;Psyche structure;Public Health;Puncture procedure;Radial;real time model;Reproducibility;Research;Robot;Robotics;Scientist;screening guidelines;Secondary to;simulation;Site;skills;software development;success;Survival Rate;System;Techniques;Technology;Time;Tissues;tool;Trachea;Training;ultrasound;United States;Universities;virtual;virtual human;Woman;Work;X-Ray Computed Tomography

PROJECT_TITLE: Real-Time Bronchoscope Localization Using Machine Learning To Improve Lung Cancer Diagnosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F15-P(20)L]


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Interstitial Cystitis;Nutrition;Pain Research;Urologic Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: SURGERY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Clinical management of interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome, two chronic, debilitating conditions characterized by pain and urinary symptoms, is currently hindered by a lack of consistently effective therapies. Our proposed study is thus important for public health because it will begin to test the utility of a promising new therapy for these two disabling conditions – personalized exclusion diets informed by food-specific antibody profiling.

PI_NAMEs: SUTCLIFFE, SIOBHAN  (contact)

PROGRAM_OFFICER_NAME: REYNOLDS, WILLIAM STUART

PROJECT_TERMS: Adopted;Affect;American;Antibodies;Antibody Response;arm;Asthma;Biological;Biological Markers;bladder pain;Blinded;Case Study;Cattle;Cell Degranulation;Chronic;Chronic pain syndrome;chronic pelvic pain;Chronic Prostatitis;Citrus Fruit;Clinical Management;clinical phenotype;Clinical Trials;cost;Crohn's disease;Cross-Over Studies;Data;Diet;dietary;Disabling condition;effective therapy;Employment;Evaluation;Exclusion;experience;Failure;Feeling suicidal;Flare;Food;Frequencies;Frustration;Functional disorder;Goals;Healthcare Systems;Histamine Release;Home;Hour;Immunoglobulin G;improved;Individual;interdisciplinary approach;Interstitial Cystitis;Intervention;Irritable Bowel Syndrome;mast cell;Mental Health;Migraine;Milk;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Pain;Participant;Pathology;Patient Self-Report;Patients;Pattern;Pelvic Pain;pharmacologic;Phase;phenotypic data;physical conditioning;Pilot Projects;pilot trial;Placebo Effect;Plasma;Predisposition;Public Health;Randomized, Controlled Trials;Recommendation;reduce symptoms;Reporting;Research;Research Personnel;Sampling;Sexual Health;side effect;success;Surveys;Symptoms;Syndrome;Testing;Text;Time;tool;urinary;urologic chronic pelvic pain syndrome;Work

PROJECT_TITLE: Food-specific antibodies and urologic chronic pelvic pain syndrome.

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy

ORG_CITY: STANFORD

ORG_STATE: CA

PHR: PROJECT NARRATIVE The recent development of immunotherapies that enhance T cell recognition and killing of malignant cells has been transformational for cancer care. However, these therapies are limited by the development of T cell ‘exhaustion,’ a process driven by chronic T cell stimulation that induces immune dysfunction pathways. The proposed research will use novel genome sequencing technologies to identify changes in genome organization that underlie human T cell exhaustion, which could be used to improve durable responses to immunotherapy in patients.

PI_NAMEs: SATPATHY, ANSUMAN  (contact)

PROJECT_TERMS: 3-Dimensional;anti-tumor immune response;Antigens;Architecture;cancer care;cancer cell;cancer immunotherapy;cancer infiltrating T cells;Cancer Patient;cancer type;Cell model;Cell Proliferation;Cell Separation;Cells;chimeric antigen receptor T cells;Chromatin;Chromosome Structures;Chromosomes;Chronic;Clinical;clinical care;Clustered Regularly Interspaced Short Palindromic Repeats;cohesin;Consensus;Coupled;CRISPR/Cas technology;Custom;Data;Data Set;design;Development;Engineering;Enhancers;Epigenetic Process;epigenomic profiling;epigenomics;exhaust;exhaustion;Exhibits;Future;Gene Expression;Genes;Genetic Transcription;Genome;genome editing;genome sciences;genome sequencing;genome-wide analysis;genomic tools;Genomics;Goals;high throughput technology;Human;Immune;Immune System Diseases;Immunology;Immunotherapy;improved;in vivo;inhibitory surface receptor;insight;Laboratories;Malignant Neoplasms;Maps;Measurement;Measures;Memory;Methods;Modeling;Molecular;Molecular Conformation;neoplastic cell;next generation;novel;Pathway interactions;Patients;Phenotype;Process;programs;promoter;Protocols documentation;Regulatory Element;Research;response;Signal Transduction;single cell ATAC-seq;Skin Cancer;Software Tools;T cell regulation;T cell response;T-Cell Development;T-Cell Receptor;T-Lymphocyte;Technology;Testing;transcriptome sequencing;treatment response;tumor;Tumor Antigens

PROJECT_TITLE: 4DN Interrogation of T Cell Exhaustion in Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(71)R]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: Since 1995, the Black Women's Health Study (BWHS), a follow-up study of 59,000 self-identified Black women, has contributed important information on individual, area-level, and genetic risk factors for cancer. With a median age of 64 and most cancers yet to occur in this cohort, and with established repositories of saliva samples, blood samples, tumor tissue samples, and mammograms, continuation of the BWHS infrastructure will further elucidate factors related to cancer incidence and survival in Black women and advance progress toward the ultimate goal of advancing the health of all women.

PI_NAMEs: BERTRAND, KIMBERLY A.;COZIER, YVETTE C;PALMER, JULIE R (contact)

PROGRAM_OFFICER_NAME: CARRICK, DANIELLE M

PROJECT_TERMS: Address;Affect;Age;Alzheimer's Disease;Archives;Behavior;Behavioral;Biological Assay;Biological Markers;Biological Specimen Banks;black women;Blood;Blood specimen;Breast;cancer diagnosis;Cancer Etiology;cancer health disparity;cancer risk;cancer survival;Cancer Survivor;Cancer Survivorship;Cardiovascular Diseases;Cessation of life;Characteristics;cohort;Collection;Colon Carcinoma;Colonic Polyps;Colorectal;Colorectal Cancer;cost;COVID-19;Data;Data Collection;Data Files;data sharing;Death Rate;Diagnosis;Disease;Disparity;DNA;DNA Repository;End stage renal failure;Endometrial;Enrollment;Environmental Exposure;Environmental Risk Factor;Ethnic Population;follow-up;Follow-Up Studies;Frequencies;Funding;Future;Genetic;genetic risk factor;Germ Lines;Goals;Health;health disparities in women;health disparity;health inequalities;Health Status;Hypertension;Impaired cognition;Incidence;indexing;Individual;Infertility;Infrastructure;interest;Knowledge;Length;Leukocytes;Link;Liver;Lung;Lupus;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;Mammary Neoplasms;Mammography;Medical;Medical Records;Medicare;Mentors;Methodology;Methods;microbial;Minority Groups;minority investigator;Modernization;Molecular Epidemiology of Cancer;mortality;Multiple Myeloma;Neighborhoods;neoplasm registry;Newly Diagnosed;Newly Diagnosed Disease;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;observational cohort study;Outcome;Ovarian;Pancreas;Paper;Participant;patient engagement;Peer Review;Pharmaceutical Preparations;Plasma;Premature Birth;Preparation;Prospective, cohort study;Psychosocial Factor;Publications;Quality of life;Questionnaires;racial disparity;racial health disparity;racial population;Recurrence;Renal Carcinoma;Reporting;repository;Research;Research Design;Research Personnel;research study;response;Risk;Risk Factors;Risk Reduction;RNA;Saliva;saliva sample;Sampling;Sarcoidosis;SARS-CoV-2 infection;Serum;Sleep Disorders;social;Source;Specimen;Structural Racism;System;Time;Tissue Banks;Tissue Microarray;Tissue Sample;Training;tumor;Tumor Tissue;Underrepresented Minority;Update;Uterine Fibroids;virtual;Vulnerable Populations;web site;Woman;Women's Health

PROJECT_TITLE: A Follow-up Study for Causes of Cancer in Black Women