ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Arthritis;Bioengineering;Neurosciences;Osteoarthritis;Physical Injury - Accidents and Adverse Effects

PHR: PROJECT NARRATIVE Anterior cruciate ligament (ACL) injury is a common orthopedic injury that results in an immediate shutdown of neural activation to the quadriceps muscle that leads to strength deficits and drives poor patient outcomes. Neuromuscular electrical stimulation (NMES) is commonly prescribed as part of the standard of care to activate the inhibited motoneurons to promote strength recovery, however the clinical success is mixed. The goal of this proposal is to maximize the effectiveness of NMES by testing specific treatment parameters and the underlying mechanisms of action in preclinical studies to provide fundamental knowledge to guide clinical practice.

PI_NAMEs: LEPLEY, LINDSEY K (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Action Potentials;Aging;Anterior Cruciate Ligament;anterior cruciate ligament injury;antioxidant therapy;Antioxidants;Architecture;Area;Biomechanics;bone;bone health;Botulinum Toxins;Calcium Signaling;Characteristics;Clinical;clinical application;clinical practice;Computer software;Custom;Data;deep learning;Development;Effectiveness;electrical property;Etiology;Exhibits;experimental group;experimental study;Future;Gait;Goals;Health;Human;Immunohistochemistry;Impairment;improved;Inflammation;Injury;Joints;Knee;Knee joint;Knowledge;limb injury;Link;Measures;Meta-Analysis;microCT;Mitochondria;mitochondrial dysfunction;Modeling;Motor;Motor Neurons;Muscle;Muscle Fibers;muscle strength;Muscular Atrophy;Musculoskeletal;neural;Neural Inhibition;neuromuscular stimulation;neurotransmission;novel;Operative Surgical Procedures;Orthopedics;Outcome;Patient-Focused Outcomes;Patients;Physical activity;Porosity;postsynaptic;Pre-Clinical Model;preclinical study;preservation;primary outcome;Production;protective effect;Protocols documentation;quadriceps muscle;Randomized;Rattus;Reactive Oxygen Species;Recovery;Rehabilitation therapy;Research;respiratory;Risk;Risk Factors;Risk Reduction;Rodent;standard of care;Stimulus;Structure;subchondral bone;success;Testing;Thick;Time;Torque;Translating;translational approach;Traumatic Arthropathy;Treatment Cost;Work

PROJECT_TITLE: Translational strategies for optimizing musculoskeletal recovery after ACL injury

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Physical Injury - Accidents and Adverse Effects;Racial and Ethnic Minority Health Research

ORG_CITY: GRAND FORKS

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF NORTH DAKOTA

ORG_STATE: ND

PI_NAMEs: MILAVETZ, BARRY IRA (contact)

PROJECT_TERMS: Adverse event;American Indians;Biological Specimen database;Biometry;Biostatistics Core;Centers of Research Excellence;Clinical Trials;Clinical Trials Data Monitoring Committees;Collaborations;Communication;Communities;community collaboration;community engagement;Community Outreach;Consent Forms;Data Analyses;data management;Databases;Engineering;Ensure;Environment;Environmental Protection;Epidemiology;Epigenetic Process;experience;Funding Agency;Funding Mechanisms;Future;Growth;Guidelines;Health Sciences;human subject;Human Subject Research;Indigenous;indigenous community;Individual;Informed Consent;Institution;Institutional Review Boards;International;Manuscripts;Methods;North Dakota;nutrition;operation;Outcome;Participant;Pilot Projects;Policies;Positioning Attribute;Process;professor;programs;Publishing;recruit;Reporting;Research;Research Design;Research Personnel;Research Project Grants;resilience research;Resources;Role;Safety;Schedule;Scholarship;Science;Services;Study Subject;synergism;Training;Trauma Research;Tribal group;tribal institution;Tribes;United States National Institutes of Health;Universities

PROJECT_TITLE: Human Subject Core


ADMINISTERING_IC: AG

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Services;Opioid Misuse and Addiction;Opioids;Patient Safety;Substance Misuse

ORG_CITY: CAMBRIDGE

ORG_NAME: NATIONAL BUREAU OF ECONOMIC RESEARCH

ORG_STATE: MA

PHR: OTHER PROJECT INFORMATION – Project Narrative Using variation in medical malpractice protection of military members and their families, this project explores the impact of malpractice pressure on the quality and quantity of patient treatment, including an analysis of liability's effects on “high-value” and “low-value” outpatient care and on opioid use. The project draws on a unique new set of data provided by the Military Health System that includes information on patient treatments and outcomes for all active military and their families.

PI_NAMEs: FRAKES, MICHAEL D. (contact);GRUBER, JONATHAN

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: active duty;Adherence;Age;age-related disease;Aging;Ambulatory Care;Attention;base;Cardiovascular Diseases;care delivery;care systems;Caring;Code;Communities;comparison group;Contracts;cost;Data;Data Set;Database Management Systems;Defensive Medicine;Diabetes Mellitus;Diagnostic tests;Dimensions;Disclosure;Disease;Environment;Equilibrium;Evaluation;Event;Family;fascinate;Fright;Health Care Costs;Healthcare;Healthcare Systems;Immunize;inpatient service;Institution;interest;Life Cycle Stages;Literature;Malignant Neoplasms;Malpractice;Measures;Medical;medical attention;Medical Liabilities;medical malpractice;Methodology;military health system;Military Personnel;Negligence;Opiate Addiction;Opioid;opioid misuse;opioid use;Patients;Pattern;Pharmacy facility;Physician-Patient Relations;Physicians;Play;Policies;Population;prescription monitoring program;prescription opioid;pressure;Privatization;Procedures;Protocols documentation;Provider;provider behavior;Quality of Care;Research;retiree;Role;service member;Services;Side;stem;surgical risk;System;Testing;treatment and outcome;treatment group;Variant;Veterans Health Administration;Work

PROJECT_TITLE: The Impact of Exempting Medical Providers from Malpractice Liability

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: TR

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Data Science;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Our study systematically addresses unresolved ethical concerns and barriers to harnessing emotional and biobehavioral PC data to improve clinical care by identifying diverse stakeholders' informational needs and perceived ethical challenges for translating PC metrics into actionable clinical knowledge. This research will carefully examine diverse stakeholders' concerns and perspectives toward risk/benefit tradeoffs of PC and will evaluate impacts of integrating PC into clinical assessments. Our methods will generate policy solutions for responsibly translating PC into clinical care, with far-reaching potential to advance precision medicine and to improve and personalize care across a range of disorders where quality of care depends on accurately eliciting and interpreting information about emotional states and behavior.

PI_NAMEs: HERRINGTON, JOHN DAVID;KOSTICK, KRISTIN MARIE (contact);STORCH, ERIC A.

PROGRAM_OFFICER_NAME: COLLIER, ELAINE S

PROJECT_TERMS: Address;Anthropology;Area;Artificial Intelligence;artificial intelligence algorithm;Asthma;Awareness;Behavior;Behavioral;Benefits and Risks;Big Data;biobehavior;Bioethics;Bioethics Consultants;Biological Markers;Cancer Detection;Caregivers;Cellular Phone;chronic pain;Classification;Clinical;Clinical assessments;clinical care;clinical research site;clinically actionable;cognitive interview;Collaborations;Collection;Communication;computer science;Consensus;Data;Decision Analysis;Decision Making;design;Deterioration;Devices;Diagnosis;digital;digital data;Disease;disorder subtype;Early Diagnosis;Emotional;emotional behavior;emotional functioning;Ensure;Ethics;Evaluation;experience;Goals;Guidelines;Healthcare;Heart failure;high standard;Human;Image;improved;indexing;Individual;Informed Consent;innovation;insight;Intake;Interview;Investments;Knowledge;Machine Learning;Maternal Health;Measures;Medical;medical specialties;Medicine;Mental disorders;Mental Health;Methodology;Methods;mHealth;Monitor;multimodality;Nervous System Disorder;novel;Ophthalmology;Outcome;Participant;patient privacy;patient safety;Patients;personalized care;personalized medicine;Phase;Policies;Policy Maker;precision medicine;Prediction of Response to Therapy;Primary Prevention;Psychiatric therapeutic procedure;Psychiatry;Psychology;Publications;Quality of Care;Radiology Specialty;Recording of previous events;Research;Research Personnel;Rest;Risk Assessment;risk mitigation;Science;Scientist;Site;Social Behavior;stem;success;Surveys;symposium;Symptoms;Technology;Telemedicine;tool;Translating;Translations;United States National Institutes of Health;wearable device

PROJECT_TITLE: Ethical and Human Factors Impacting Successful Translation of Perceptual Computing to Improve Clinical Care


ADMINISTERING_IC: DK

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: PISCATAWAY

ORG_DEPT: NUTRITION

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: The intestine is an important regulatory and signaling organ, enabling diet-derived nutrients to perform essential actions. In this project, we explore a novel role for an intestinal lipid-metabolizing protein, stearoyl- CoA desaturase-1 (SCD1), in regulating whole body lipid levels and metabolic health. These studies have important translational implications to the development of novel nutritional and pharmaceutical therapies for maintaining and improving cardiometabolic health.

PI_NAMEs: SAMPATH, HARINI  (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Ablation;absorption;Acids;Acute;Address;Agonist;Animal Feed;Animals;bile acid metabolism;Bile Acids;Bile fluid;Biliary;Brown Fat;Caco-2 Cells;cardiometabolism;Cardiovascular Diseases;Cell Line;Cholesterol;Chylomicrons;Data;Development;Diet;dietary;energy balance;Energy Metabolism;Enterocytes;Epithelial Cells;Esterification;Fatty Acids;Fatty Liver;feeding;G-Protein-Coupled Receptors;Gene Expression;glucagon-like peptide 1;glucose metabolism;glucose tolerance;GPBAR1 gene;Health;Hepatic;Hepatobiliary;Homeostasis;Human;Hyperlipidemia;improved;inhibitor;Insulin Resistance;Intestinal Content;intestinal epithelium;Intestines;Knowledge;Link;lipid metabolism;lipidomics;Lipids;Lipoproteins;Liver;LoxP-flanked allele;Measurement;Measures;Mediating;Metabolic;metabolic phenotype;Monounsaturated Fatty Acids;mouse model;Mus;Mutation;novel;Nutrient;Nutritional;Oral Administration;Organ;Pathology;Peroxisome Proliferator-Activated Receptors;Pharmacologic Substance;Plasma;Proteins;receptor;Receptor Signaling;Regulation;reuptake;Role;Saturated Fatty Acids;Signal Transduction;SIRT1 gene;Skin;Stearoyl-CoA Desaturase;Sucrose;Testing;Tissues;uptake;virtual

PROJECT_TITLE: The role of intestinal SCD1 in regulating metabolic health


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative Alzheimer's disease (AD) and AD related dementia (AD/ADRD) poste a serious public health crisis in the aging population. Although the disease disproportionately affect the elderly, with women having a significantly higher rate than men, few sex-specific studies have been conducted in older women. In the study, we have two specific aims: Aim 1: To examine the association of vascular, metabolic and inflammatory biomarkers with risk of incident MCI and dementia in women aged 65 and older. Aim 2: To develop a machine learning (ML)-enabled algorithm to predict individuals who are at high risk of incident MCI and dementia.

PI_NAMEs: LIU, LONGJIAN  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Address;Adult;Affect;Age;aged;aging population;aging related;Algorithms;Alleles;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid beta-Protein;Apolipoprotein E;Biological Markers;Blood;Blood Vessels;Brain;Chronic;Cognitive;cohort;Cohort Studies;Data;Dementia;dementia risk;Development;Diabetes Mellitus;Diagnosis;Dimensions;Disease;disorder risk;Dyslipidemias;Early Diagnosis;Elderly;Encephalitis;experience;fluorodeoxyglucose positron emission tomography;Functional disorder;Genes;Genetic;genetic risk factor;hazard;health care settings;high risk;human old age (65+);Hyperglycemia;Impairment;indexing;Individual;Inflammation;Inflammatory;innovation;insight;Ionizing radiation;Journals;Judgment;Late Onset Alzheimer Disease;Literature;Longevity;Machine Learning;Magnetic Resonance Imaging;Measures;meetings;Memory;men;mental state;Metabolic;Metabolic Diseases;Metabolic syndrome;Methods;middle age;mild cognitive impairment;Modeling;Modification;neuroimaging;Neurosciences;normal aging;novel;older adult;older women;Outcome;Outcome Study;Participant;Pathology;Patients;Population;Population Study;Predictive Factor;predictive modeling;Predictive Value;Predictive Value of Tests;Prevention;Prevention Measures;Primary Health Care;Proteins;Public Health;Publishing;Questionnaires;Reporting;Research;Research Design;Risk;Risk Factors;risk prediction;risk prediction model;Sample Size;Sampling Studies;Secondary to;sex;Short-Term Memory;Signal Transduction;Special Equipment;tau Proteins;Testing;Thinking;Time;tool;Vascular Diseases;vascular risk factor;volunteer;Woman;Women's Health

PROJECT_TITLE: The predicative values of vascular and metabolic disorders for risk of incident mild cognitive impairment and dementia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Q(55)R]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics;Human Genome;Osteoporosis

ORG_CITY: SEATTLE

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE  By 2050, osteoporosis is expected to affect >50% of Americans over the age of 50; further, osteoporotic hip fracture incidence is expected to increase by >200% compared to rates in 1990. Recent studies have identified a large number of loci associated with bone mineral density (BMD), an important clinical marker for osteoporosis diagnosis. This project aims to define causal genes at these loci to understand their biological mechanisms, and in turn, identify new drug targets for osteoporosis therapies.

PI_NAMEs: KWON, RONALD Y (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Adult;Affect;Age;American;Biological;Biology;bone;Bone Density;bone fragility;bone mass;bone quality;Candidate Disease Gene;Case Study;causal variant;Characteristics;Chromosomes;Chronic Disease;Clinical;Clinical Markers;CRISPR/Cas technology;Data;Diagnosis;Drug Targeting;Exhibits;gene discovery;Gene Expression;gene function;Genes;Genetic;genetic analysis;genetic risk factor;Genetic Screening;genetic variant;genome wide association study;genome-wide;Genomic Segment;Germ Lines;Goals;Health;Heritability;Hip Fractures;Human;Human Genetics;human genomics;in vivo;Incidence;Individual;innovation;Knowledge;loss of function;loss of function mutation;Measures;Meta-Analysis;microCT;Modeling;Modification;Molecular;Morphology;Mus;mutant;new therapeutic target;novel;Osteoblasts;Osteogenesis Imperfecta;Osteoporosis;Osteoporotic;Pathway interactions;Persons;Phenotype;Proteins;Rapid screening;reverse genetics;Risk;Serine;Signal Transduction;skeletal;Skeleton;Testing;trait;Translating;virtual;Work;Zebrafish

PROJECT_TITLE: Causal Genes at BMD Loci

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Narrative The proposed studies will yield fundamental and novel knowledge regarding the role of human constitutive androstane receptor (hCAR) in liver cancer development, which is profoundly different from its rodent counterparts. The anticipated outcomes will offer proof-of-concept evidence that hCAR has an anticancer function that represses the growth of hepatoma cells. These studies will also explore the mechanisms underlying hCAR-mediated suppression of human liver cancer, which may eventually lead to novel strategies in controlling liver cancer.

PI_NAMEs: WANG, HONGBING  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Affect;Agar;Amino Acids;anti-cancer;Apoptosis;Apoptotic;Carcinogens;Cell Line;Cell Proliferation;Clinical;constitutive androstane receptor;Data;design;Development;Diagnosis;Disease;DNA biosynthesis;Down-Regulation;drug clearance;drug metabolism;Ectopic Expression;Environment;epidemiology study;Erythropoietin;Erythropoietin Receptor;Event;Exhibits;Gene Cluster;Genes;genetic approach;Genetic Transcription;Growth;Growth Factor;Hepatic;Hepatocarcinogenesis;Hepatocyte;hepatoma cell;Homeostasis;Human;Human Activities;In Vitro;in vivo;Incidence;insight;Invaded;Knowledge;Liver;liver cancer model;liver cell proliferation;Liver neoplasms;Malignant neoplasm of liver;Mediating;migration;Modeling;Molecular;Mus;novel;novel marker;novel strategies;novel therapeutics;Nuclear;Nude Mice;Oncogenes;Oncogenic;Outcome;overexpression;Patient-Focused Outcomes;pharmacologic;Phenobarbital;Physiological;Play;Primary carcinoma of the liver cells;Prognosis;Protein Isoforms;Proteins;Rattus;Receptor Activation;receptor expression;Receptor Inhibition;Receptor Signaling;Repression;response;RNA Splicing;Rodent;Role;Sampling;sensor;Signal Transduction;Testing;Therapeutic;Tissues;transcriptome;transcriptome sequencing;Transgenic Mice;Transgenic Organisms;tumor;tumor growth;tumor progression;Tumor Promoters;Tumor Suppressor Proteins;tumor xenograft;tumorigenesis;Variant;Xenobiotics;Xenograft procedure

PROJECT_TITLE: Novel noncanonical actions of CAR in human Liver

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Overall – PROJECT NARRATIVE Decades of research have generated new knowledge and tools with the potential to prevent all new HIV infections and improve the lives of all persons living with HIV. Unfortunately, reality falls far short of these goals. The Tennessee Center for AIDS Research leverages complementary strengths of its four partner institutions to have broad and substantial impact on the HIV epidemic.

PI_NAMEs: KOETHE, JOHN  (contact)

PROGRAM_OFFICER_NAME: SCHOONMAKER, ANNALISE ROSA

PROJECT_TERMS: Academic Medical Centers;Acquired Immunodeficiency Syndrome;Address;Affect;African American population;Area;career development;Collaborations;Communities;community engaged research;community engagement;community organizations;community partnership;data dashboard;design;Development;Disease Outbreaks;Doctor of Philosophy;Environment;Epidemic;experience;Extramural Activities;falls;Fostering;Funding;Goals;Health;Health Sciences;high risk;HIV;HIV Infections;HIV Seronegativity;HIV/AIDS;implementation science;improved;Institution;Knowledge;Laws;Leadership;Medical;medical schools;Minority Groups;Mission;multidisciplinary;Needle-Exchange Programs;next generation;novel;Persons;Populations at Risk;Postdoctoral Fellow;prevent;Public Policy;Research;Research Personnel;Resources;Rural;Science;Scientist;Southeastern United States;success;surveillance data;synergism;Tennessee;tool;translational impact;Underserved Population;United States;United States National Institutes of Health;Vision;Work;working group

PROJECT_TITLE: Tennessee Center for AIDS Research (TN-CFAR)


NIH_SPENDING_CATS: Aging;American Indian or Alaska Native;Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

PHR: Project Narrative Cardiovascular disease is the leading cause of mortality among American Indian populations, and investigations of early-life determinants of cardiovascular disease are warranted. The proposed project will examine multiple pathways linking maternal ACEs and infant growth, a recognized risk factor for cardiovascular disease in adulthood. This project will highlight specific pathways that could potentially be modified to reduce future risk of cardiovascular disease among American Indian populations.

PI_NAMEs: WILLIAMS, ANDREW DAVID (contact)

PROJECT_TERMS: Acculturation;Address;Adult;adverse childhood events;Age;aged;aging population;American Heart Association;American Indian community;American Indian Population;American Indian Women;American Indians;Biological;Birth;Breast Feeding;cardiometabolic risk;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;career;Centers of Research Excellence;Child;childhood adversity;Chronic stress;cohort;culturally appropriate intervention;Data;Death Rate;Development;Dose;Enrollment;Epidemiology;Ethnic Population;Event;Exposure to;feeding;follow-up;Future;Gestational Diabetes;Goals;Growth;Hair;Health;health disparity;Hydrocortisone;Hypertension;hypothalamic-pituitary-adrenal axis;Indigenous;Individual;Infant;infant outcome;intergenerational;Investigation;Life;life span;Linear Regressions;Link;Logistic Regressions;Low Birth Weight Infant;Maternal and Child Health;Maternal Health;maternal outcome;Measurement;Measures;Mediating;Mediator;Medical;Medical Records;Mental Health;Mentors;Methods;Morbidity - disease rate;mortality;Mothers;North Dakota;Northern Plains;novel;obstetric outcomes;Pathway interactions;pediatric trauma;Population;Postpartum Period;Pregnancy;pregnancy disorder;pregnant;Premature Birth;Premature Mortality;prenatal;Prospective, cohort study;Psychosocial Factor;racial population;Reporting;Research;Research Project Grants;resilience research;response;Risk;Risk Factors;Role;Sampling;Small for Gestational Age Infant;social;Stress;Substance abuse problem;Surveys;Testing;Time;transmission process;Trauma;Trauma Research;traumatic event;tribal community;United States;Violence;White Women

PROJECT_TITLE: Stress and Health in American Indian Pregnancies


NIH_SPENDING_CATS: Aging;Arthritis;Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease;Neurosciences;Rheumatoid Arthritis

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

ORG_STATE: NY

PHR: Public Health Relevance NIGMS supported work in the Tracey lab leads the field of bioelectronic medicine, holding promise to benefit patients by using electronic devices to replace their drugs. It is based on the science of targeting molecules to stop inflammation, which affects millions of patients with arthritis, inflammatory bowel disease, diabetes, asthma, Alzheimer's, heart disease and stroke. The studies proposed here focus on how the brain and nervous system control inflammation in order to design new bioelectronic therapies.

PI_NAMEs: TRACEY, KEVIN J (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Affect;Alzheimer's Disease;Anatomy;Arthritis;Asthma;Award;Basic Science;bioelectronics;Brain;brain control;clinical investigation;clinical practice;Clinical Trials;Crohn's disease;design;Diabetes Mellitus;disease model;Electronics;Electrophysiology (science);Environment;experience;Funding;Heart Diseases;Imaging technology;Immune system;Immune System Diseases;Immunity;Immunobiology;Immunology;Inflammation;Inflammatory;Inflammatory Bowel Diseases;innovation;Knockout Mice;Lead;Medicine;Methods;Mission;Molecular;National Institute of General Medical Sciences;Natural Immunity;Nervous System;Nervous System control;neural;Neurobiology;neurophysiology;neurotransmission;optogenetics;Patients;Pharmaceutical Preparations;programs;public health relevance;Publications;Reflex action;Reporting;Research;Rheumatoid Arthritis;Science;Series;Stroke;Transgenic Organisms;Translating;Vagus nerve structure;Work

PROJECT_TITLE: Molecular basis of bioelectronic medicine

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: MALLAL, SIMON ALEXANDER (contact)

PROJECT_TERMS: Academic Medical Centers;Acquired Immunodeficiency Syndrome;Address;aged;base;biomedical informatics;career development;centralized portal;Collaborations;collaborative environment;Communication;Communities;community engaged research;community organizations;County;Data Collection;empowerment;Epidemic;Event;experience;Feedback;flexibility;Fostering;Funding;Future;Goals;Grant;Health;HIV;HIV/AIDS;Human Resources;improved;Individual;informatics tool;Infrastructure;innovation;Institution;Leadership;male;medical schools;member;Mentors;Mission;Monitor;next generation;Occupational activity of managing finances;Office of Administrative Management;Operating System;Operations Research;Persons;Prevalence;Process;Productivity;programs;Research;Research Activity;Research Personnel;Research Support;Resources;Risk;rural area;Science;Services;Southeastern United States;Strategic Planning;Structure;success;Supervision;symposium;Tennessee;Time;Trust;United States;United States National Institutes of Health;urban area;web site;Work;working group

PROJECT_TITLE: Administrative Core (Core A)


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Rare Diseases

ORG_CITY: ATLANTA

ORG_DEPT: NEUROSURGERY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The overarching goal of this proposal is to advance a large animal model of spinal cord glioma (SCG) as a translational platform. We will accomplish this by scaling and adapting previously implemented strategies for vector- driven gene transfer of oncogenes and shRNA knockdown of genes implicated in gliomagenesis to induce SCG of variable phenotype. This will provide improved utility for preclinical therapeutic testing and surgical device development with varied grade, growth rate, and underyling genetic lesions.

PI_NAMEs: BOULIS, NICHOLAS M (contact);CANOLL, PETER

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: Address;Anatomy;Animal Model;Animals;Astrocytoma;Behavioral;Biological Models;Biopsy;Canis familiaris;CDKN2A gene;Characteristics;Chemoresistance;Clinical;clinically relevant;Contrast Media;Convection;Data;design;Development;Device or Instrument Development;Disease;Drug Delivery Systems;drug distribution;effective therapy;Epidermal Growth Factor Receptor;Evaluation;Excision;experience;experimental group;Failure;Family suidae;Future;Gadolinium;Gene Transfer;Genes;Genetic;Glioma;Gliomagenesis;Goals;Growth;High Pressure Liquid Chromatography;Histopathology;Human;human disease;Immunocompetent;Implantable Pump;improved;Individual;Indolent;Infusion procedures;knock-down;Knowledge;Laboratories;Lesion;Magnetic Resonance Imaging;Malignant - descriptor;Measures;Mediating;Miniature Swine;Modeling;Molecular;Monitor;Morbidity - disease rate;mortality;Nature;Neurologic Deficit;neurosurgery;Oncogenes;Operative Surgical Procedures;Outcome;Pathway interactions;Patients;PDGFB gene;Phase;phase I trial;Phenotype;PIK3CG gene;Platelet-Derived Growth Factor;porcine model;pre-clinical;Process;PTEN gene;radiation resistance;Radiology Specialty;Rare Diseases;Recurrence;Reflux;Refractory;Reporting;Rodent;Rodent Model;Safety;Serial Magnetic Resonance Imaging;small hairpin RNA;Spinal Cord;Spinal Cord Neoplasms;standard of care;Study models;Surgical margins;Surgical Models;Survival Rate;System;Testing;Therapeutic;therapeutic evaluation;TP53 gene;transcriptomics;transgene delivery;Transgenes;translational impact;translational study;Translations;tumor;tumor growth;Tumor Suppression;vector

PROJECT_TITLE: Lentiviral-Induced Swine Model of Spinal Cord Glioma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-N(55)R]


PROJECT_TERMS: Academic Medical Centers;Academic skills;Acquired Immunodeficiency Syndrome;African American;Applications Grants;Award;base;Blood;career;career development;Center for Translational Science Activities;Clinical Research;Collaborations;Communicable Diseases;community organizations;comorbidity;Development;Doctor of Philosophy;Ensure;Evaluation;experience;Extramural Activities;Faculty;Feedback;Fostering;Funding;Funding Agency;Funding Mechanisms;Funding Opportunities;Goals;Grant;Health;Health Disparities Research;Heart;HIV;HIV/AIDS;Immunology;innovation;Institution;Leadership;Link;Lung;Manuscripts;Medical center;medical schools;Medicine;meetings;member;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Microbiology;mid-career faculty;minority health;minority investigator;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;outreach;Periodicals;Physicians;Physiology;Pilot Projects;Positioning Attribute;Productivity;professor;programs;Public Health;Research;Research Personnel;Research Project Grants;Research Training;Resource Development;Resources;response;Role;Scientist;Series;skill acquisition;skills;Sleep;Strategic Planning;Structure;success;Teacher Professional Development;Tennessee;Training;Translational Research;Tuberculosis;United States National Institutes of Health;Women's Health;Work;Writing

PROJECT_TITLE: Developmental Core (Core B)


PI_NAMEs: HAAS, DAVID W (contact)

PROJECT_TERMS: Academic Medical Centers;Acquired Immunodeficiency Syndrome;aged;Agreement;AIDS clinical trial group;Applications Grants;Award;base;Biological;career;career development;Clinic;Clinical;Clinical Research;Clinical Sciences;cohort;Collaborations;Communities;community based participatory research;community organizations;community partners;Comprehensive Health Care;Consultations;County;Coupled;Data;Data Science Core;Data Set;database design;Databases;Development;Disease Outbreaks;Doctor of Philosophy;Environment;Epidemic;Epidemiology;Extramural Activities;Fostering;Funding;Goals;Grant;Harm Reduction;Health;Hepatitis C virus;HIV;HIV Infections;HIV-1;HIV/AIDS;HIV/HCV;Infection;Infrastructure;Institution;Investigation;Joints;Laws;Leadership;male;Manuscripts;medical schools;Mission;Modeling;next generation;Outcome;Participant;Patient Recruitments;Persons;Placenta;Policies;Postpartum Period;Prevalence;Process;Productivity;programs;Publications;Publishing;recruit;Research;Research Design;Research Personnel;Research Project Grants;research study;Research Support;Resources;response;Risk;Risk Assessment;rural area;Science;Scientist;Services;Southeastern United States;Specimen;success;Support Groups;Tennessee;Time;Tissues;Translational Research;United States National Institutes of Health;urban area;volunteer;Woman;Work

PROJECT_TITLE: Clinical Sciences Core (Core C)


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Microbiome;Prevention;Substance Misuse

PI_NAMEs: KALAMS, SPYROS A (contact)

PROJECT_TERMS: Academic Medical Centers;Acquired Immunodeficiency Syndrome;Address;Adipose tissue;Administrative Supplement;Adoption;Area;B-Cell Antigen Receptor;B-Lymphocytes;Basic Science;Biological Assay;Biomass;career development;Cell Physiology;Cell Separation;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clinical;Clinical Sciences;Collaborations;Consultations;Core Facility;Cryopreservation;design;digital;Discipline;Disease;DNA;DNA sequencing;Equipment;Flow Cytometry;Funding;Future;Gene Expression Profiling;genetic variant;genomic platform;Genomics;Grant;Health;HIV;HIV Genome;host microbiome;human genomics;Immunology;In Vitro;Individual;innovation;Institution;integration site;Investments;Laboratories;laboratory experience;Leadership;Lymphocyte;Measures;medical schools;Metagenomics;Methodology;microbial;microbial genomics;microbiome analysis;microbiome sequencing;Mission;nano-string;Nucleic Acids;Pathogenesis;Performance;Peripheral Blood Mononuclear Cell;Phenotype;Plasma;Population;Procedures;Proteins;Protocols documentation;Recording of previous events;Research;Research Design;Research Personnel;Resources;Ribosomal RNA;RNA;Role;Saliva;Sampling;Schedule;Science;Sequence Analysis;Services;single cell genomics;single cell sequencing;Skin;Sorting;Specimen;Stains;success;synergism;System;T cell receptor repertoire sequencing;T-Lymphocyte;Techniques;Technology;Tennessee;Tissues;Training;transcriptomics;Translational Research;Viral Genome;viral genomics;Work

PROJECT_TITLE: Laboratory Sciences Core (Core D)


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Complex structural variants are a frequent but underexplored aspect of cancer genomes that may drive aggressive tumors and reflect treatable defects in DNA repair. While long-range and single cell genomic profiling technologies have matured, algorithms for inferring complex structural variants from these data are lacking. This proposal will develop such algorithms and apply them to study the evolution of pyrgo, a recently identified complex structural variant class prevalent in ovarian and prostate cancer.

PI_NAMEs: CHOO, ZI-NING  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Algorithms;Alleles;Automobile Driving;cancer genome;Cells;Chromatin Loop;Chromatin Structure;Complex;computer framework;computerized tools;Data;data modalities;data structure;Defect;Development;DNA;DNA copy number;DNA Repair;dosage;driver mutation;Evolution;Gene Rearrangement;Genome;genome sequencing;genomic profiles;genomic profiling;Genomic Segment;Genomics;Graph;Haplotypes;Homologous Gene;Individual;Lesion;Link;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;Modeling;Mutation;new technology;novel;Ovarian Adenocarcinoma;Pattern;Phase;Phylogenetic Analysis;Positioning Attribute;Prognostic Marker;Prostate Adenocarcinoma;Recurrence;repaired;single cell genomics;Single-Stranded DNA;Structure;Systemic Therapy;Taxonomy;Technology;Tissue Sample;tool;tumor;Variant;whole genome;Work

PROJECT_TITLE: Inferring the structure and evolution of tandem duplication towers


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: SHEPHERD, BRYAN EARL (contact)

PROJECT_TERMS: Academic Medical Centers;Acquired Immunodeficiency Syndrome;Address;analytical method;Applications Grants;Area;Atmosphere;Award;Bioinformatics;bioinformatics pipeline;biomedical informatics;Biometry;Cells;Clinic;Clinical Sciences;Collaborations;Communities;community organizations;community partners;computer science;Consult;cost;Data;Data Analyses;Data Analytics;Data Collection;data curation;Data Linkages;data resource;Data Science;Data Science Core;Data Scientist;Data Set;data tools;Databases;Development;Doctor of Philosophy;experience;Feedback;Fruit;Funding;genomic data;Goals;Group Meetings;Health;HIV;HIV/AIDS;Immunology;improved;Informatics;informatics tool;Infrastructure;Institution;Instruction;International;investigator training;Journals;Knowledge;Laboratories;Leadership;Link;medical schools;member;Mentorship;method development;Methods;Microbiology;mid-career faculty;Mission;Names;novel;Outcome;Pathology;professor;programs;Publications;Records;Research;Research Design;Research Personnel;Research Support;Resources;Role;Rotation;Science;Services;Site;Statistical Data Interpretation;Statistical Methods;Strategic Planning;success;Technology;Tennessee;tool;tool development;Training;transcriptomics;Trust;United States National Institutes of Health;Walking;Work;working group

PROJECT_TITLE: Data Sciences Core (Core E)


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Staphylococcus aureus is the leading cause of cardiac device infections, a devastating complication that jeopardizes the function of these lifesaving devices. This research proposal will build novel bioengineered model systems to examine how specific patient and bacterial factors interact to influence why some people with S. aureus bloodstream infection and cardiac devices (pacemakers, artificial heart valves) develop an infection of their cardiac device while others do not. The results from this research can be used to develop new diagnostics to identify patients at high risk for developing a cardiac device infection or new therapeutics to augment a person's ability to fight these infections.

PI_NAMEs: MASKARINEC, STACEY A (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: 3-Dimensional;Academic Medical Centers;Affect;Antibiotic Resistance;Automobile Driving;Award;Bacteremia;Bacterial Model;biobank;Biological;Biological Markers;Biological Models;Biology;biomarker identification;biomarker panel;biomarker signature;Biomedical Engineering;Blood Vessels;cardiac device;cardiac implant;Cardiovascular Diseases;Cardiovascular system;career;cell behavior;Cell Communication;Characteristics;Clinical;Clinical Data;Clinical Research;cohort;Cohort Studies;Collaborations;Complication;cost;cytokine;Device Removal;Devices;Diagnosis;Disease;Early identification;Economic Burden;Endothelial Cells;Endothelium;Engineering;Etiology;Excision;experience;Faculty;fighting;follow-up;Goals;Healthcare Systems;Heart Valve Prosthesis;high risk;Homeostasis;Human;Hydrogels;Immune;Immune response;improved;In Vitro;in vitro Model;Individual;Infection;infection risk;International;Leadership;Left;Life;mechanical properties;mechanical stimulus;Mechanics;Mentors;Methods;microbial;Modeling;Molecular;mortality;National Heart, Lung, and Blood Institute;novel;novel diagnostics;novel therapeutics;Operative Surgical Procedures;Outcome;outcome prediction;Pacemakers;Patients;Performance;Persons;Phenotype;Physicians;Physiological;Play;Predisposition;Prevention;prospective;Prospective cohort;Published Comment;Publishing;Quality of life;Research;Research Personnel;Research Proposals;Resources;response;Risk;Risk Factors;Role;Sampling;Schools;Scientist;Selectins;Sepsis;Serum;shear stress;skills;Staphylococcus aureus;Staphylococcus aureus infection;Symptoms;System;Testing;therapeutically effective;Tissue Engineering;Tissue Model;treatment response;Validation;Variant;Vascular Diseases;Work;working group

PROJECT_TITLE: Staphylococcus aureus Cardiac Device Infections - From the Vascular Viewpoint

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project Narrative Each year, more than 12 million women in the U.S. will be recommended for diagnostic work-up for concern of breast cancer and must navigate multiple steps including breast imaging tests, breast biopsies, and specialist consultations before diagnostic resolution. Compared to screening mammography, surprisingly little is known about how differences in breast cancer diagnostic work-up contribute to the persistently higher morbidity and mortality experienced by women of minority race/ethnicity and lower socioeconomic status. We will conduct the largest observational study to date on breast cancer diagnostic evaluation involving 1.4 million U.S. women across 198 individual practices to identify novel diagnostic quality of care indicators that can be used to develop interventions and guidelines aimed at closing the persistent breast cancer disparities gap.

PI_NAMEs: LEE, CHRISTOPH I (contact)

PROGRAM_OFFICER_NAME: CROSWELL, JENNIFER

PROJECT_TERMS: Address;Adherence;advanced breast cancer;Advanced Malignant Neoplasm;Affect;Biometry;Biopsy;black women;Breast biopsy;Breast Cancer Detection;breast cancer diagnosis;Breast Cancer Epidemiology;Breast Cancer Surveillance Consortium;breast imaging;burden of illness;Cancer Diagnostics;cancer health disparity;cancer imaging;care coordination;care episode;Caring;Characteristics;clinically significant;Complex;Consultations;Continuity of Patient Care;Data;data resource;Data Science;Data Sources;Decentralization;Diagnosis;Diagnostic;Diagnostic Imaging;diagnostic technologies;disadvantaged women;Disparity;disparity gap;Disparity in diagnosis;Disparity population;disparity reduction;Education;Equity;ethnic minority;Ethnic Origin;Ethnic Population;Evaluation;experience;Failure;follow-up;Future;Goals;Guidelines;health care delivery;health care disparity;health determinants;Health Services Research;Image;Image Guided Biopsy;Imaging technology;improved;Individual;Inequity;innovation;Insurance;Intervention;Link;Low income;low socioeconomic status;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Mammography;Mediating;Mediation;Medicine;Morbidity - disease rate;mortality;multilevel analysis;multiple data sources;Nature;novel;novel diagnostics;Observational Study;Operative Surgical Procedures;Outcome;outcome disparities;Play;Policies;Positioning Attribute;practice factors;Practice Guidelines;Procedures;Provider;Quality of Care;Race;racial disparity;racial minority;racial minority women;racial population;Radiology Specialty;Recommendation;Registries;Research;Residential Treatment;Resolution;Role;rural residence;screening;screening disparities;Services;socioeconomic disadvantage;socioeconomic disparity;Socioeconomic Status;Specialist;Stage at Diagnosis;standard of care;Statistical Models;Survival Rate;Testing;Time;Tissues;Transportation;tumor;ultrasound;Underinsured;Vulnerable Populations;White Women;Woman

PROJECT_TITLE: Racial and Socioeconomic Disparities in Breast Cancer Diagnostic Work Up and Outcomes

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE To advance our understanding of Glioblastoma (GBM) therapeutic resistance, it is essential to characterize the individual cell during therapy those fueling tumor recurrence in GBM. We have identified a novel mechanism of Ribonucleotide Reductase promoting resistance by performing a single-cell RNA sequencing screen in the patient-derived xenograft model of GBM during temozolomide (TMZ) TMZ therapy. This application is set to evaluate Ribonucleotide Reductase as a target to overcome therapeutic resistance in GBM.

PI_NAMEs: AHMED, ATIQUE U. (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Address;Anabolism;Attention;Blood;Brain;Cancer Patient;cancer stem cell;cell growth;Cell Proliferation;Cells;Chemoresistance;chemotherapy;ChIP-seq;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Combined Modality Therapy;Complex;Data;deoxyguanosine triphosphate;Disease Progression;DNA;DNA biosynthesis;DNA Damage;DNA Maintenance;DNA Repair;Engraftment;Enzymes;Epigenetic Process;epigenetic regulation;Equilibrium;experimental study;Family;Funding;Genome;Glioblastoma;Goals;Guanine;Heterogeneity;Human;improved outcome;In Vitro;in vivo;Individual;inhibitor;insight;Inter-tumoral heterogeneity;Isotope Labeling;Isotopes;Knock-out;Knowledge;Learning;Legal patent;Measures;Mediating;Metabolic;Modification;Molecular;Mus;nanodrug;neoplastic cell;novel;novel strategies;Nucleotides;Pathway interactions;patient derived xenograft model;Patients;Permeability;Pre-Clinical Model;prevent;Primary Brain Neoplasms;Primary Neoplasm;Process;Production;Protein Isoforms;Purines;Radiation therapy;Recurrence;Recurrent tumor;Regulation;Research;Resistance;resistance mechanism;response;Ribonucleotide Reductase;Ribonucleotide Reductase Subunit;RRM1 gene;Safety;Sampling;single cell analysis;single-cell RNA sequencing;stem cell population;stemness;Stress;temozolomide;Testing;Therapeutic;therapy resistant;Time;Toxic effect;Treatment Efficacy;treatment response;Triapine;tripolyphosphate;tumor

PROJECT_TITLE: Cellular Plasticity and equilibrium in GBM Progression

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PHR: NARRATIVE Alzheimer’s disease (AD) is the most common neurodegenerative disorder and currently has no disease- modifying treatment. Regulatory T cells (Tregs) express several NMDA-type glutamate receptors (NMDARs), including GluN1, GluN2A, GluN3A and GluN3B; however, the effect of glutamate on Tregs migration/activation has not been reported, and, specifically, it is not known how this might impact neurons in Alzheimer’s disease (AD) brain. In this study we will utilize human cells: Tregs isolated from blood and hiPSC-derived microglia and neurons to study the interaction between these cells and understand how glutamate regulates the crosstalk between microglia and Tregs in Alzheimer’s disease.

PI_NAMEs: LIPTON, STUART A (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: abeta oligomer;acquired immunity;Adaptive Immune System;adaptive immunity;Affect;alpha synuclein;Alzheimer's Disease;Alzheimer's disease brain;Amyloid beta-Protein;Anti-Inflammatory Agents;Astrocytes;Binding;Blood;Blood donor;Bone Marrow;Brain;Cell Communication;Cell Death;cell motility;Cell Physiology;Cell Separation;Cells;Central Nervous System;Cessation of life;chemokine;Coculture Techniques;Cues;cytokine;Development;Disease;Electrophysiology (science);Excitatory Amino Acid Antagonists;exposed human population;Exposure to;Fluorescent Probes;Functional disorder;Future;gene correction;Gene Expression;Glutamate Receptor;Glutamates;Human;human induced pluripotent stem cells;human old age (65+);Immune;Immune response;immunoregulation;Induced pluripotent stem cell derived human neuron;Inflammation;Inflammatory;Inflammatory Response;Innate Immune System;insight;Interleukin-10;Ion Channel;Knowledge;Macrophage;Measures;Memantine;Methods;Microglia;misfolded protein;Mutation;N-Methylaspartate;Natural Immunity;Neurodegenerative Disorders;neuroinflammation;neuronal survival;Neurons;neuroprotection;NMDA receptor A1;novel therapeutic intervention;patch clamp;Pathogenesis;Pathway interactions;Persons;phosphoneuroprotein 14;Prevalence;prevent;Protocols documentation;Publishing;Receptor Activation;receptor expression;recruit;Regulatory T-Lymphocyte;Reporting;response;Signal Transduction;Stimulus;Synapses;System;T-Cell Activation;T-Lymphocyte;Testing;Time;Transforming Growth Factor beta;Western Blotting;Work;Yolk Sac

PROJECT_TITLE: Crosstalk between innate-immunity human microglia and adaptive-immunity Tregs in Alzheimer's disease


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Harm Reduction for Substance Misuse;Health Services;Infectious Diseases;Prevention;Substance Misuse

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE For people who use drugs in Uganda, services for harm reduction as well as HIV prevention remain in their infancy, despite a growing epidemic and potential for up to 45% of drug users to be living with HIV. The proposed work leverages methods from implementation science to develop, pilot, and determine the cost of two approaches to integrated harm reduction and PrEP delivery – a facility-based model within a medication-assisted treatment program and a community-based model for needle and syringe exchange. Results will have implications for the Ugandan context, as well as communities in the US, by demonstrating co-location of PrEP and harm reduction services and novel data on PrEP adherence and retention among people who use drugs.

PI_NAMEs: HEFFRON, RENEE A. (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: addiction;Adherence;Advocate;Africa;AIDS prevention;antiretroviral therapy;Attention;budget impact;Buprenorphine;Capital;Cities;Cocaine;Communicable Diseases;Communities;community based participatory research;Consensus;Consolidated Framework for Implementation Research;Consultations;cost;cost estimate;Data;Drug usage;Drug user;Educational workshop;Empathy;Ensure;Epidemic;Equipment;evidence base;experience;follow-up;Funding;Guidelines;Harm Reduction;Health;Hepatitis C;Heroin;HIV;HIV Seronegativity;Human immunodeficiency virus test;implementation science;improved;infancy;Injectable;Injecting drug user;Injections;Intervention;Interview;Knowledge;Measures;medication-assisted treatment;member;Methods;Modeling;multidisciplinary;Needle-Exchange Programs;Needles;novel;Oral;pathogen;Persons;Pharmaceutical Preparations;Plasma;Police Forces;Policies;Population;pre-exposure prophylaxis;preference;prescription pain reliever;Prevalence;Prevention;Prevention Guidelines;prevention service;programs;Provider;Qualitative Research;recruit;Reporting;Research;Risk;scale up;Scientist;Service delivery model;Service provision;Services;Site;social;social stigma;Surveys;Syringes;Tenofovir;trafficking;transactional sex;transmission process;treatment program;Uganda;Update;uptake;willingness;Work

PROJECT_TITLE: Implementation science research on PrEP delivery and costing within MAT andNSP services for PWUD in Uganda


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Cystic Fibrosis;Lung;Pediatric;Rare Diseases

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE  The advent of CFTR modulators, a new class of therapies which correct the underlying protein defect in CF, have led to a dramatic improvement in the lives of those with CF. However, underlying airway inflammation persists and currently no studies that have examined the effect of inflammation on response to modulators or trialed therapies to augment response. The knowledge gained in this study will improve understanding of the impact of airway inflammation in the post-modulator era and potentially identify a widely-available, well-tolerated therapy (losartan) to improve response to CFTR modulator therapy.

PI_NAMEs: BENGTSON, CHARLES  (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Affect;airway inflammation;airway surface liquid;Angiotensin II Receptor;Anti-Hypertensive Agents;Anti-Inflammatory Agents;Biometry;Blinded;bronchial epithelium;career development;Childhood;Chlorides;Chronic;Clinic;Clinical;Clinical Research;Clinical Trials;Clinical Trials Design;Cross-Sectional Studies;cyclooxygenase 2;Cystic Fibrosis;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;cytokine;Data;Defect;Delta F508 mutation;design;Development Plans;Diagnostic;Double-Blind Method;Enrollment;Ensure;Epithelial Cells;Evaluation;experience;FDA approved;functional restoration;Genes;Genetic Diseases;Goals;Human;Hydration status;Hyperglycemia;Ibuprofen;Impairment;improved;improved outcome;In Vitro;in vivo;Individual;individualized medicine;Inflammation;Inflammation Mediators;inflammatory marker;inhibitor;insight;Ion Channel;Knowledge;Lead;Length;Life;Link;Liquid substance;Losartan;Lung;Lung infections;Measurement;Measures;Mediator;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;microbial colonization;Morbidity - disease rate;mortality;mRNA Expression;Mucociliary Clearance;Mucous body substance;mutant;Mutation;Nasal Epithelium;next generation;Nose;novel;Observational Study;Outcome;patient screening;Patients;peripheral blood;Persons;Pharmaceutical Preparations;Pilot Projects;Population;Positioning Attribute;pre-clinical;prognostic;Property;Proteins;Pulmonary Cystic Fibrosis;pulmonary function;pulmonary function decline;Quality of life;Randomized;Regression Analysis;Research;Research Personnel;response;Sampling;secondary outcome;Signal Transduction;Surrogate Markers;targeted treatment;Techniques;Testing;TGFB1 gene;Therapy trial;Time;Training;Transforming Growth Factor beta;Translating;treatment response;United States;VX-770

PROJECT_TITLE: Targeting inflammation to improve rescue of CFTR by modulator therapy

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


NIH_SPENDING_CATS: Diabetes;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Narrative: Gestational diabetes mellitus (GDM) is characterized by high blood sugar levels during pregnancy. About 1 out of 10 pregnant women develops GDM - a major complication that imposes a significant risk on the health of both mothers and babies. Our goal is to understand how pancreatic β-cells compensate for pregnancy to gain mechanistic insights into β-cell failure in GDM.

PI_NAMEs: DONG, HENGJIANG HENRY (contact)

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: Address;Adverse effects;Affect;Beta Cell;Blood;Blood Glucose;Cellular Metabolic Process;ChIP-seq;Compensation;Complication;Cues;Data;Development;Diabetes Mellitus;Diagnosis;euglycemia;Failure;Fasting;Female;Fetus;forkhead protein;FOXO1A gene;Gestational Diabetes;Glucose;Glucose Intolerance;glucose metabolism;Goals;Health;hormonal signals;Hormones;Hyperglycemia;impaired glucose tolerance;Impairment;in vivo;insight;Insulin;Insulin Resistance;insulin secretion;insulin signaling;islet;Knockout Mice;Link;maternal weight;Mediating;Metabolic stress;Modeling;Mothers;Mus;Nuclear;Nutritional;Outcome;Pathway interactions;Phosphorylation;Physiological;Plasma;Play;Predisposition;Pregnancy;pregnant;Pregnant Women;Prolactin;Prolactin Receptor;Proliferating;Protein Tyrosine Kinase;Receptor Signaling;Regulation;response;Risk;Role;Signal Transduction;single-cell RNA sequencing;Structure of beta Cell of islet;Techniques;Third Pregnancy Trimester;transcription factor;transcriptome;transcriptome sequencing;Tyrosine Phosphorylation;Weight Gain;Wild Type Mouse

PROJECT_TITLE: FoxO1 in Gestational Diabetes

STUDY_SECTION: CADO

STUDY_SECTION_NAME: Cellular Aspects of Diabetes and Obesity Study Section[CADO]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cerebral Palsy;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Rehabilitation;Precision Medicine;Rehabilitation

ORG_CITY: BOYS TOWN

ORG_NAME: FATHER FLANAGAN'S BOYS' HOME

ORG_STATE: NE

PHR: PROJECT NARRATIVE Cerebral palsy (CP) is one of the most prevalent and costly developmental disabilities in the United States. Many adolescents with CP do not respond well to the current physical therapy protocols, and the mechanisms underlying the response variability are not fully understood. This proposal will use neuroimaging to understand the underlying mechanisms for responders and non-responders to current treatments.

PI_NAMEs: KURZ, MAX J (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: Acceleration;Address;Adolescent;Aftercare;Axon;Brain;Brain imaging;Cerebral Palsy;Characteristics;Childhood;Classification;Clinical;clinically relevant;cohort;cost;Coupled;Data;density;design;Development;Developmental Disabilities;Diameter;Direct Costs;Economic Burden;Exhibits;Face;Feedback;Fiber;foot;Future;Gait;gait rehabilitation;imaging approach;imaging study;Imaging Techniques;Impairment;improved;improved mobility;indexing;Individual;Influentials;innovation;insight;Interneurons;Investigation;kinematics;Knowledge;Leg;Lower Extremity;Magnetic Resonance Imaging;Magnetoencephalography;Mechanoreceptors;meter;Mobility decline;Motor;Movement;multimodality;Muscle;Muslim religion;myelination;neural;neuroimaging;Neurologic;neurophysiology;Neurosciences;novel;Outcome;Perception;Perinatal Brain Injury;Peripheral;Physical therapy;Play;Positioning Attribute;prevent;Production;Protocols documentation;Reaction Time;Research Design;responders and non-responders;response;Sensory;Sensory impairment;Series;Societies;somatosensory;Somatosensory Cortex;Spinal Cord;spinal cord imaging;Structure;targeted treatment;temporal measurement;Testing;Therapeutic;Therapeutic Intervention;Tissues;Treatment outcome;treatment program;treatment response;United States;walking speed;Work;Youth

PROJECT_TITLE: NEUROPHYSIOLOGY OF RESPONDERS AND NON-RESPONDERS WITH CEREBRAL PALSY


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: CORAL GABLES

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE Black/African American (AA) older adults are vastly underrepresented in Alzheimer’s disease (AD) research despite the high prevalence of the disease in this population. This novel and innovative study will reduce prevalent barriers to participation by implementing home-based assessment and blood collection, provide technology, and facilitate door-to-door transportation services to MRI and amyloid PET imaging facilities. Novel cognitive assessment using our Cognitive Challenge Tests (CCTs) and the deep phenotyping proposed including state-of the-science blood-based biomarkers of AD and neurodegeneration using advanced Single Molecule Array (SiMoA) technology, MRI and PET neuroimaging, and examining the potential contributions of common co-morbid conditions (e.g., cerebrovascular disease, diabetes, and chronic kidney disease, etc.) and social determinants of health will answer important questions regarding how our novel CCTs map onto sensitive biomarkers for the early detection of preclinical and prodromal AD among AA individuals.

PI_NAMEs: CURIEL CID, ROSIE E;LOEWENSTEIN, DAVID  (contact)

PROGRAM_OFFICER_NAME: PERCY-LAURRY, ANTOINETTE LOIS

PROJECT_TERMS: Acceleration;Accounting;Address;African American;African American population;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;amnestic mild cognitive impairment;Amyloid;Amyloid beta-42;Amyloidosis;Apolipoprotein E;Basal Nucleus of Meynert;Biological Markers;Black race;Blood;blood-based biomarker;Brain region;Cerebrospinal Fluid;cerebrovascular;Cerebrovascular Disorders;Chronic;Chronic Kidney Failure;Clinical;Clinical Research;Clinical Trials;Cognition;Cognitive;cognitive change;Cognitive deficits;cognitive performance;cognitive testing;cohort;Collection;comorbidity;computerized;Data;Databases;design;Diabetes Mellitus;Diagnostic;Diffusion Magnetic Resonance Imaging;Disease;early detection biomarkers;Early Diagnosis;Enrollment;Ensure;entorhinal cortex;Equipment;European ancestry;Exhibits;experience;extracellular;Failure;follow-up;Funding;genetic risk factor;Glial Fibrillary Acidic Protein;Goals;High Prevalence;Hippocampus;Hispanic;Home;imaging facilities;imaging study;Impaired cognition;Individual;Inflammation;inflammatory marker;innovation;Kidney Diseases;Knowledge;Latino;Learning;learning materials;Light;Location;Magnetic Resonance Imaging;Maps;Measures;Medical;Memory;Metabolic;mild cognitive impairment;Modeling;Nerve Degeneration;neurofilament;neuroimaging;neuropathology;Neuropsychology;Not Hispanic or Latino;novel;older adult;Older Population;Participant;Performance;performance tests;Phenotype;Plasma;Population;Positron-Emission Tomography;pre-clinical;prodromal Alzheimer's disease;prognostic;recruit;Reproducibility;Research;Research Proposals;research study;Resource Sharing;Risk;Sampling;Science;Semantics;Services;single molecule;social health determinants;structural determinants;Technology;Testing;Therapeutic;Time;Transportation;user-friendly;Water;water diffusion;Work

PROJECT_TITLE: Innovative Deep Phenotyping of African Americans at Risk for Alzheimers disease

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Biomedical Imaging;Chronic Pain;Clinical Research;Osteoarthritis;Pain Research

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The proposed project aims to 1) comprehensively quantify cartilage and bone pathologies in the development of human knee OA to better understand disease pathogenesis and 2) develop an innovative quantification method of subchondral bone microstructure to assess and potentially predict knee OA progression in human subjects.

PI_NAMEs: GUO, X. EDWARD (contact);SHANE, ELIZABETH J

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: 3-Dimensional;Accounting;Address;Adult;Affect;Age;Animals;articular cartilage;Basic Science;Biological Markers;bone;bone loss;Bone remodeling;Bone Resorption;Cartilage;cartilage degradation;Clinical;Clinical Research;Clinical Sciences;clinically significant;Collection;comparison control;Computed Tomography Scanners;Data;Degenerative polyarthritis;Development;diagnostic tool;disability burden;Disease;disorder prevention;Drug usage;Early Diagnosis;Etiology;Evaluation;follow-up;Fractals;Generations;Human;human subject;Imaging Techniques;in vivo;in vivo evaluation;in vivo imaging;Individual;innovation;insight;Joints;Knee;Knee Injuries;Knee Osteoarthritis;Knowledge;Link;longitudinal analysis;Magnetic Resonance Imaging;Measurement;Measures;men;Methods;microCT;Monitor;Musculoskeletal Diseases;novel;novel marker;Pain;Pathogenesis;Pathologic;Pathology;Patients;Peripheral;radiological imaging;Reporting;Research;Resolution;Rod;Roentgen Rays;Role;Scanning;Sclerosis;Secondary to;Structure;subchondral bone;substantia spongiosa;Synovial Membrane;Techniques;Texture;Thick;Tissues;tool;Validation;Woman;X-Ray Computed Tomography

PROJECT_TITLE: Subchondral Trabecular Plate and Rod Abnormalities in Human Osteoarthritis


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: RELEVANCE  The proposed project has direct clinical relevance to Alzheimer’s disease, a devastating neurodegenerative disorder that is the sixth leading cause of death in the US and affects 44 million people worldwide. The disease presents a significant economic burden as it costs the US over billions of dollars each year and places significant social and psychological burden on caregivers. In response to this looming public health crisis in the United States, the proposed study will obtain experimental evidence for the role of cerebral microvasculature in the disease and provide a computational framework to better investigate and understand the role.

PI_NAMEs: LEE, JONGHWAN  (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: abeta accumulation;Address;Affect;Age;age related;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Animal Husbandry;Behavioral;Biological Markers;Biological Models;Biomedical Engineering;Blood capillaries;Blood flow;Blood Vessels;Caregiver Burden;Cause of Death;cerebral microvasculature;Cerebrum;Clinical Research;clinically relevant;comorbidity;computer framework;Computer Models;Consensus;cost;Data;Defect;Dementia;Development;Diagnosis;Dietary Intervention;Disease;Early Diagnosis;Early treatment;Economic Burden;Epidemic;Etiology;exercise intervention;Failure;Functional disorder;gene therapy;human old age (65+);Hyperemia;hypoperfusion;Image;image processing;Imaging technology;Impaired cognition;improved;in vivo;in vivo imaging;Individual;insight;interest;Knowledge;Laboratory Animals;life span;Measures;Medical History;Microcirculation;Modeling;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;Neurons;Neurosciences;neurovascular coupling;new technology;normal aging;Optical Coherence Tomography;Oxygen;Pathogenesis;Pathology;Persons;Pharmaceutical Preparations;pharmacologic;Play;Population;Process;Property;psychologic;Public Health;Research Project Grants;Resolution;response;Risk Factors;Role;Senile Plaques;simulation;social;Structure;System;Techniques;Technology;Testing;therapeutic target;Thinness;Three-Dimensional Image;Time;tool;United States;vascular factor

PROJECT_TITLE: Long-Term Tracking of Cerebral Microvascular Structural and Functional Alterations between Normal and Alzheimer's Aging


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Narrative:  Increasing evidence suggests that “reservoirs” of HIV-infected cells which persist on anti-HIV medicines (“ART”), and especially those cells that produce HIV RNA and/or protein (“active reservoirs”), cause ongoing damage despite treatment and also allow the virus to relapse when treatment is stopped, preventing cure. In this program project grant, multiple novel and cutting-edge technologies will be applied to samples from different groups of HIV-infected individuals in order to understand how the diverse reservoirs of HIV-infected cells that do or do not produce different forms of HIV RNA and/or protein differ in many respects, including their cell numbers, survival, clearance by immune responses, contribution to inflammation, production of human RNA and proteins, differences across tissues, contribution to virologic relapse after stopping anti-HIV medicines, and susceptibility to new therapies aimed at HIV cure. Findings from these studies will generate a wealth of new knowledge about these HIV-infected reservoirs, which may lead to new approaches aimed at HIV cure or improved tolerance of lifelong infection.

PI_NAMEs: YUKL, STEVEN A (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Acute;acute infection;Autopsy;Binding;Bioinformatics;Biological Assay;Blood;Cell Count;Cells;chronic infection;Clinical;clinical phenotype;cohort;Collaborations;Complex;Custom;Data;Defect;differential expression;DNA;Drug or chemical Tissue Distribution;Environment;experimental study;Frequencies;Funding;Gene Expression;Genes;Genetic Transcription;Goals;Heterogeneity;HIV;Human;Immune;immune activation;immune clearance;Immune response;improved;In Situ;in vivo;Individual;Infection;Inflammation;Integration Host Factors;Interruption;Intervention;Knowledge;Lead;Life Expectancy;lymph nodes;Lymphoid Cell;Measures;Medicine;Metabolic Clearance Rate;Monitor;multidimensional data;multidisciplinary;Myeloid Cells;nano-string;novel;novel strategies;novel therapeutics;Organ;Persons;Phenotype;Population Heterogeneity;Predisposition;prevent;Production;Program Research Project Grants;programs;Proteins;Proteome;Proteomics;Proviruses;Relapse;Research;Research Personnel;Residual state;Resource Allocation;Resources;RNA;RNA Splicing;Sampling;single-cell RNA sequencing;Sudden Death;Survival Rate;synergism;Technology;Testing;Time;Tissues;Transcript;transcriptome;transcriptomics;Translating;Translations;Viral;Viral Genes;viral rebound;viral RNA;Virus

PROJECT_TITLE: The heterogeneous HIV expressing reservoir: dynamics, persistence mechanisms, tissue distribution, and contribution to rebound


NIH_SPENDING_CATS: Kidney Disease;Prevention

ORG_CITY: TAMPA

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: Acute kidney injury (AKI) is associated with higher risk of developing chronic kidney disease (CKD). In the present proposal, we will examine the significance of macula densa NOS1 and NOS1-modulated tubuloglomerular feedback in AKI to CKD transition.

PI_NAMEs: LIU, RUISHENG  (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: 3-Phosphoinositide Dependent Protein Kinase-1;Acute Renal Failure with Renal Papillary Necrosis;Address;Adenosine;Adult;adverse outcome;African American population;arteriole;Blood Pressure;Cells;Chronic Kidney Failure;Closure by clamp;constriction;cost;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;cytokine;Data;Development;Elderly;Excretory function;Exhibits;Feedback;Generations;Glomerular Filtration Rate;Health;High Prevalence;high risk;Histology;improved;In Vitro;in vivo;Injury to Kidney;Juxtaglomerular Apparatus;Kidney;Laboratories;laser capture microdissection;Macula densa;Measurement;Measures;Mediating;Microdissection;Micropuncture;Modeling;mouse model;Mus;Nephrons;new therapeutic target;Nitric Oxide;Nitric Oxide Synthase;Nitric Oxide Synthase Type I;Optics;Outcome;overexpression;Pathway interactions;Perfusion;Persons;Phosphatidylinositols;Play;prevent;Prevention;Recovery;Renal function;renal ischemia;Reperfusion Injury;response;Risk Factors;RNA Splicing;Role;Sodium;Survivors;Techniques;Testing;therapeutic target;Time;Tubular formation;Variant;Waste Products

PROJECT_TITLE: Tubuloglomerular feedback response in AKI to CKD transition

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-W(05)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative The human pathogen Neisseria gonorrhoeae (Ngo) is the causative agent of gonorrhea and remains a major public health concern due to increasing rates of antibiotic resistance and lack of a protective vaccine. The work will investigate a protein that I hypothesize Ngo uses to acquire zinc in metal-limited conditions. Understanding the metal transport mechanism Ngo utilizes to undermine host-mediated metal limitation will translate into development of targeted new therapies against this antibiotic-resistant bacterium.

PI_NAMEs: LIYAYI, IAN KIMANI (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Affect;Antibiotic Resistance;Bacterial Antibiotic Resistance;bacterial genetics;Bacterial Physiology;Binding;Biochemistry;Bioinformatics;career;Cells;chelation;Collaborations;combat;Data;Development;drug resistant bacteria;Epithelial Cells;Epithelium;Exposure to;extracellular;gene product;Genes;Gonorrhea;Growth;Human;human pathogen;Immune;Immunity;in vivo;Infection;Iron;Laboratory Research;Lactoferrin;Leukocyte L1 Antigen Complex;Macrophage;Manganese;Mediating;member;Membrane Transport Proteins;Metals;Microbiology;Mucositis;Mucous Membrane;Neisseria;Neisseria gonorrhoeae;neutrophil;new therapeutic target;novel;novel therapeutics;Nutrient;Nutritional Immunity;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;periplasm;Proteins;psoriasin;Public Health;Regulation;Regulon;Repression;Role;Sexually Transmitted Diseases;Site;Starvation;Surface;System;Testing;Training;Transcript;Transferase;Transferrin;Translating;uptake;Vaccine Therapy;Vaccines;Work;Zinc;zinc-binding protein

PROJECT_TITLE: Understanding the role of Ngo1049 in subverting host-mediated metal starvation in Neisseria gonorrhoeae


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

ORG_CITY: CHAPEL HILL

ORG_DEPT: SURGERY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Narrative: Aortic Aneurysm (AA) is a major cause of morbidity and mortality; AAs weaken the vessel wall and lead to dilation that often progresses to rupture in the absence of symptoms. There are no point-of-care diagnostic tests available that either screen for AAs or follow disease progression to optimize timing for surgical intervention. This award will advance a standardized screening technique that determines aneurysm presence, location, and diameter; such information may be used for risk stratification and will surely mitigate life-threatening aortic complications in the general population.

PI_NAMEs: AKERMAN, ADAM WILLIAM (contact)

PROGRAM_OFFICER_NAME: STABLEY, JOHN N

PROJECT_TERMS: access disparities;Advanced Development;Algorithms;Aneurysm;Aorta;Aortic Aneurysm;Aortic Rupture;Award;Basic Science;biobank;Biochemical;Biological Assay;Biological Markers;Blood;Blood specimen;Blood Tests;Blood Vessels;Cardiovascular system;Cause of Death;Cell Communication;Cells;Charge;circulating microRNA;classification trees;Clinical;clinical diagnostics;Collagen;cost;cost efficient;Data;Detection;Development;Diagnosis;Diagnostic;diagnostic assay;Diagnostic tests;diagnostic tool;Diameter;digital;Disease;Disease Progression;disenfranchised population;Dissection;Early Diagnosis;Early identification;economic disparity;Elastin;Elderly;Elements;Enzymes;Epidemiologist;Equipment;Etiology;Evaluation;exosome;experimental study;Exposure to;Extracellular Matrix;extracellular vesicles;General Population;Geography;Growth;health care availability;health equity;Hospitals;Human;Image;Imaging Techniques;insight;instrument;Laboratories;Life;Location;Magnetic Resonance Imaging;marginalized community;Matrix Metalloproteinase Inhibitor;Matrix Metalloproteinases;Measures;Mediator;Methods;MicroRNAs;microvesicles;Molecular Sieve Chromatography;Monitor;Morbidity - disease rate;mortality;novel;novel diagnostics;nucleic acid detection;Operative Surgical Procedures;Pathologic;Pathology;Pathway interactions;Patients;Peptide Hydrolases;Persons;Physiologic pulse;Pilot Projects;Plasma;Play;point of care;point-of-care diagnostics;Predictive Value;Process;Proteolysis;Radiation;regression trees;repository;Reproducibility;Resources;Risk;Risk Assessment;risk stratification;Rupture;Sampling Studies;Scientist;screening;Severities;Signal Pathway;Specificity;Standardization;Stress;Structure;Surface;Surgeon;Suspensions;Symptoms;Techniques;Technology;Testing;Thoracic Aortic Aneurysm;Tissue Inhibitor of Metalloproteinases;Tissues;Transforming Growth Factor beta;Translating;Translational Research;Translations;United States;Untranslated RNA;X-Ray Computed Tomography

PROJECT_TITLE: Enhanced Biochemical Monitoring for Aortic Aneurysm Disease

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Genetics

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Disrupted cell metabolism is the root cause for numerous diseases. We have identified a novel protein modification that regulates metabolism and cellular redox. This proposal will elucidate the regulation of these modifications in health and disease.

PI_NAMEs: GALLIGAN, JAMES J (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Antioxidants;Autoimmunity;Award;Biological;Biology;Carbon;Cell Line;Cell model;Cells;Cellular Metabolic Process;Chromatin;CRISPR/Cas technology;Cues;Dedications;Diabetes Mellitus;Disease;Global Change;Glutathione;Glycolysis;Goals;Health;Histones;Homeostasis;in vivo;Inflammatory;Knock-out;Laboratories;Lactoylglutathione Lyase;Lysine;Malignant Neoplasms;Metabolic;Metabolic Diseases;Metabolism;Methods;Modification;novel;Output;Oxidation-Reduction;Oxidative Stress;Post-Translational Protein Processing;programs;Proliferating;Proteins;Proteomics;Reader;Reduced Glutathione;Regulation;Research;response;Role;Sampling;sensor;Sepsis;Signal Transduction;Site;Site-Directed Mutagenesis;Therapeutic;Transcriptional Regulation;Treatment Efficacy;treatment strategy;Xenograft Model

PROJECT_TITLE: Establishing Glyoxalase 2 as a Viable Target for the Treatment of Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Clinical Research;Complementary and Integrative Health

ORG_CITY: CHARLESTOWN

ORG_NAME: SPAULDING REHABILITATION HOSPITAL

ORG_STATE: MA

PHR: A critical component of acupuncture theory and therapy is the existence of specific locations across the body surface where inserting and manipulating a needle can engender salubrious, clinically beneficial effects. These locations are termed acupuncture points, or acupoints, and have been the source of great controversy for the acupuncture research field. Our platform, called the Topological Atlas and Repository for Acupoint research (TARA), forms an invaluable Research Resource Center for the acupuncture research and clinical community by strengthening the biological basis of acupoints, facilitating acupuncture integration into clinical care.

PI_NAMEs: HARRIS, RICHARD E;HELMER, KARL GERARD;NAPADOW, VITALY  (contact)

PROGRAM_OFFICER_NAME: HORGUSLUOGLU, EMRIN U

PROJECT_TERMS: 3-Dimensional;Acupuncture Points;Acupuncture Therapy;Anatomy;Atlases;Biological;Body Surface;Cadaver;Caring;chronic painful condition;Clinical;clinical care;Communication;Communities;Cryoultramicrotomy;Data;data access;Data Collection;Data Set;Databases;East Asian;Ensure;evidence base;experience;Female;Foundations;Funding;Future;Human;human female;human model;International;interoperability;Knowledge Management;Lead;Link;Location;Magnetic Resonance Imaging;male;Maps;Medicine;method development;Modernization;National Center for Complementary and Integrative Health;Needles;Nomenclature;novel;Ontology;open-access repositories;Organ;outreach;Peripheral;Persons;Physiological;Physiology;Publishing;Rattus;repository;Research;Research Personnel;Resolution;Resources;Rodent;Scanning;Science;searchable database;Societies;Source;Standardization;Switzerland;System;Technology;theories;United States National Institutes of Health;Universities;Visualization software;web portal;Work;World Health Organization


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Regenerative Medicine;Transplantation

ORG_CITY: SEATTLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative Liver disease causes more than two million deaths worldwide per year, and unlike most other major killers, deaths due to liver disease are rapidly rising rather than falling. We are working to address this major medical challenge by building bioartificial livers that can serve as a bridge or alternative to transplantation. Here, we will 3D print human liver tissue that grows within the body and therapeutically rescues mice with liver disease.

PI_NAMEs: STEVENS, KELLY R (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: 3D Print;Acceleration;Address;Architecture;Artificial Liver;Artificial tissue;Biocompatible Materials;bioink;Biological;Biomedical Engineering;bioprinting;Bioreactors;Blood capillaries;Blood Vessels;Cellular biology;Cessation of life;Clinical;Collaborations;Data;density;Diameter;Disease;drug metabolism;Engineering;Engraftment;falls;Formulation;Generations;Goals;Growth;Heart Diseases;Hepatic;Hepatocyte;hepatocyte engraftment;Hepatology;Human;implantation;improved;In Situ;in vivo;in vivo engraftment;injured;Ink;innovation;interstitial;Kidney Diseases;Libraries;Life;Liver;Liver diseases;Liver Failure;liver injury;liver metabolism;liver transplantation;Lobule;Measures;Medical;meter;Methods;multidisciplinary;Mus;Natural regeneration;novel strategies;novel therapeutics;Operative Surgical Procedures;Organ;Organ Transplantation;Osteogenesis;Pancreatic Diseases;Patients;Pattern;Physiology;Printing;Protein Biosynthesis;Public Health;regenerative growth;Research;Resolution;Role;Route;scale up;self assembly;support network;Technology;Testing;Therapeutic;Tissue Engineering;Tissues;Transplantation;vascular tissue engineering;Vascularization;Work

PROJECT_TITLE: Photoabsorbing bioinks for expanding 3D printed human liver in situ

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Organ Transplantation;Racial and Ethnic Minority Health Research;Social Determinants of Health;Transplantation

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Project Narrative Racial disparities in the incidence and treatment of end-stage kidney disease are well-documented and largely consistent across outcomes, and an emerging consensus indicates that these disparities are likely to be primarily driven by structural racism (SR). We will develop theoretically-driven, innovative measures of SR using restricted microdata and other sources, analyze the role of SR in racial/ethnic disparities in end-stage kidney disease incidence and mortality outcomes, determine how best to operationalize meaningful racial/ethnic disparities in sequences of kidney disease therapies, and work with two established community advisory boards to develop proposed interventions to ameliorate racial/ethnic disparities in kidney disease on the basis of our findings.

PI_NAMEs: DAW, JONATHAN KYLE (contact)

PROGRAM_OFFICER_NAME: NORTON, JENNIFER MICHELLE

PROJECT_TERMS: Affect;Alaska Native;Alaska Native population;American Indians;Black race;Characteristics;Chronic Disease;Chronic Kidney Failure;Clinical;Communication;Communities;community advisory board;community engagement;complex data;Consensus;Data;Data Analyses;Data Set;Demographer;Development;Dialysis procedure;Dimensions;Disease;disease disparity;Disparate;Disparity;Economics;Education;Eligibility Determination;End stage renal failure;ethnic disparity;ethnic minority;Ethnic Origin;Etiology;experience;Future;graft failure;hazard;Health;Health Professional;Health Services;Health Surveys;Healthcare;Hemodialysis;high risk;Hispanic;Hispanic Populations;Incidence;Information Systems;innovation;Institution;Institutional Policy;Intervention;Interview;Kidney;Kidney Diseases;Kidney Transplantation;Life Cycle Stages;Link;living kidney donor;Measures;Medical;Medicare;Medicare claim;mortality;Not Hispanic or Latino;novel;optimal treatments;Outcome;Participant;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Peritoneal Dialysis;Politics;Population;Positioning Attribute;post-transplant;Process;Race;racial disparity;racial minority;Research;Research Personnel;Respondent;Role;Sampling;Selection Bias;Sequence Analysis;shape analysis;Social Conditions;Social Policies;Source;Structural Racism;Surveys;Survival Rate;Techniques;Testing;Time;Transplantation;treatment disparity;United States;Waiting Lists;Work

PROJECT_TITLE: The Impact of Structural Racism on Racial/Ethnic Disparities in End-Stage Kidney Disease from Healthy Population to Mortality


ORG_CITY: CINCINNATI

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative The human genome encodes a diverse collection of membrane tethered enzymes that play vital roles in human health and disease pathogenesis; however, the molecular and atomic details that govern enzyme activity are poorly understood. Here, I present a basic research program to study these different enzyme families, using a multidisciplinary approach, to reveal unifying themes in ectodomain shedding and unique characteristics that position the enzyme into its biological niche.

PI_NAMEs: SEEGAR, TOM C M (contact)

PROJECT_TERMS: Address;Affect;Basic Science;Binding;Biological;Biology;Cell Adhesion;Cells;Cellular biology;Characteristics;Collection;Complex;Development;Disease;Disintegrins;Electron Microscopy;Enzyme Activation;enzyme activity;Enzyme Precursors;Enzymes;Event;experience;Family;Fertilization;Foundations;genetic regulatory protein;Goals;Health;Heart Valves;Homeostasis;Human;Human Genome;Immunity;innovation;interdisciplinary approach;Knowledge;Mass Spectrum Analysis;Membrane;Membrane Proteins;Metalloproteases;Modeling;Molecular;Pathogenesis;Peptide Hydrolases;Play;Positioning Attribute;Principal Investigator;Process;programs;Property;Proteins;Proteomics;Regulation;Research;rhomboid;Role;Signal Transduction;Signal Transduction Pathway;skin morphogenesis;skin organogenesis;Specificity;structural biology;Structure;Translating;X-Ray Crystallography

PROJECT_TITLE: Structure and Regulation of Ectodomain Sheddases in Development and Disease

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: PROJECT NARRATIVE Elevated risk of maternal mortality in African-American women is a complex and urgent problem in the US, and approaches that take into account social determinants of health along with clinical factors to understand and mitigate this risk are sorely needed. We propose to develop, in collaboration with patient, provider, and community support personnel stakeholders, a machine learning-based technology to link biological, clinical, and social determinants of health data, identify risk factors for conditions antecedent to maternal mortality, and translate this understanding of risk into user-facing apps designed to support the individual and shared decision-making of patients, providers, and community support personnel. The project will include needs assessment, systems development, pilot-level deployment, and evaluation phases.

PI_NAMEs: GURCAN, METIN NAFI;PAGE, CHARLES DAVID;STUEBE, ALISON M (contact)

PROGRAM_OFFICER_NAME: BOUGH, KRISTOPHER J

PROJECT_TERMS: Address;African American Women;analytical method;Architecture;Awareness;Biological;Board Certification;Caring;Clinical;clinical decision support;clinical predictors;clinical risk;Collaborations;Communication;Communities;Complex;Comprehensive Health Care;Computer software;Custom;Data;data integration;Data Mart;Death Rate;design;Development;digital health;Disparity;Education;Elements;Evaluation;experience;falls;fetal medicine;Goals;health application;health data;health disparity;Health Technology;Healthcare;Healthcare Systems;Heart Diseases;Hemorrhage;high risk;Housing;Human;Human Resources;Hypertension;improved;Income;Individual;Informatics;informatics tool;Information Systems;Infrastructure;innovation;Institution;interest;Intervention;Intervention Studies;Link;Machine Learning;machine learning algorithm;machine learning method;Maternal Health;maternal morbidity;Maternal Mortality;maternal risk;Maternal-fetal medicine;Measurement;mortality;mortality risk;Needs Assessment;North Carolina;nutrition;Outcome;outcome prediction;patient portal;Patient risk;Patients;Phase;Pilot Projects;Play;population health;Practical Robust Implementation and Sustainability Model;Provider;Public Health Informatics;racial disparity;Research;Research Personnel;Resource-limited setting;Risk;Risk Factors;risk mitigation;risk prediction;risk stratification;Role;severe maternal morbidity;shared decision making;Site;social health determinants;Socioeconomic Status;Structure;System;system architecture;Systems Development;Technology;technology intervention;technology platform;Testing;Translating;Transportation;Trust;usability;White Women

PROJECT_TITLE: Analytics & Machine-learning for Maternal-health Interventions (AMMI): A Cross-CTSA Collaboration


ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: PROJECT NARRATIVE We have uncovered an emerging role for protein ubiquitination in regulating beta-cell death in T1D. Here, we will use tools from chemical biology, cell biology, and mouse biology to develop a greater understanding of the complex signaling in the beta cell during T1D development and pursue an innovative therapeutic hypothesis for the treatment of T1D.

PI_NAMEs: CHOUDHARY, AMIT  (contact);KULKARNI, ROHIT N.

PROJECT_TERMS: activity-based protein profiling;Alberta province;analog;Apoptosis;Area;Autoimmune Diabetes;Autoimmune Diseases;Beta Cell;Binding;Biology;Cell Death;Cell Line;Cell Physiology;Cell Survival;Cellular biology;cellular targeting;Chemicals;chemoproteomics;Clinical;Complex;Complications of Diabetes Mellitus;cytokine;Cytokine Signaling;Development;Diabetes Mellitus;Diabetic mouse;Disease;early detection biomarkers;Equilibrium;Event;Gene Expression Profiling;Genetic;Goals;Heart;Human;Hypoglycemia;Immune;Immune Targeting;improved;In Vitro;in vivo;Individual;Inflammatory;innovation;Insulin;Insulin-Dependent Diabetes Mellitus;Interferon Type II;Interleukin-1 beta;islet;JAK2 gene;Kidney;kinase inhibitor;knock-down;Label;Lysine;Measurable;Measurement;Mediating;Methods;Modeling;Morbidity - disease rate;mortality risk;mouse model;Mus;Mutate;Non obese;novel therapeutic intervention;Outcome;Pancreas;Pathway interactions;Patients;Peripheral Nerves;Phenotype;Phosphorylation;Phosphotransferases;Post-Translational Protein Processing;preservation;prevent;Process;Proteins;Proteomics;response;Retina;Risk;Role;screening;Signal Transduction;small molecule;STAT1 gene;Structure of beta Cell of islet;Therapeutic;TNF gene;tool;Tyrosine;Ubiquitin;ubiquitin isopeptidase;Ubiquitination;Universities

PROJECT_TITLE: Interrogating the ubiquitin pathway to understand and treat cytokine-induced beta-cell death in type 1 diabetes

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: Jupiter

ORG_NAME: ALPHA YOUNG LLC

PHR: PROJECT NARRATIVE Patients with chronic kidney disease (CKD) are at high risk for developing cardiovascular disease, but as diseas progression leads to costly dialysis or high-risk transplantation, therapies to protect the heart and vasculature and to increase lifespan do currently not exits. Soluble klotho (sKL) is a protein in the blood with protective effects on various organs, and sKL levels are reduced in CKD patients and are thought to contribute to CKD-associated pathologies, such as cardiovascular damage. Alpha Young LLC has developed an early-stage mimetic protein of sKL, and here we will introduce and test additional mutations to increase sKL’s stability and bioactivity, in order to develop a novel drug with widespread protective effects that can be injected into patients with CKD and prolong their survival.

PI_NAMEs: YANUCIL, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: CONAGE-POUGH, JASON EDWARD

PROJECT_TERMS: Affinity;Animal Model;Animals;Binding;Biological;Biological Assay;Biological Markers;Blood;bone;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;cardiovascular injury;cardiovascular risk factor;Cardiovascular system;Caring;Cause of Death;Cell Culture Techniques;cell type;Cells;Cessation of life;Chronic Kidney Failure;Circulation;Clinical Trials;cost;design;Dialysis procedure;drug candidate;drug development;Drug Targeting;Excretory function;extend lifespan;FGFR4 gene;Fibroblast Growth Factor;fibroblast growth factor 23;Fibroblast Growth Factor Receptor 1;Fibroblast Growth Factor Receptors;Fibroblasts;Fibrosis;Functional disorder;Future;Generations;Genetic;glycosylation;Goals;Half-Life;Heart;heart damage;Heart Hypertrophy;Heparin;Heparin Binding;high risk;Hormones;Hypertrophy;improved;in vivo evaluation;Individual;Inflammation;Inhibition of Apoptosis;Injections;inorganic phosphate;Integral Membrane Protein;Kidney;Kidney Transplantation;klotho protein;Label;Laboratories;Length;Liver;Lysine;Mass Spectrum Analysis;Measures;Mediating;Metabolism;Methods;mimetics;Minerals;Modeling;mortality;mouse model;Mus;mutant;Mutate;Mutation;novel;novel therapeutic intervention;novel therapeutics;Organ;overexpression;Oxidative Stress;paracrine;Pathologic;Pathology;Patients;Phage Display;Phase;Physiological;Point Mutation;preclinical study;preservation;prevent;Procedures;Production;Property;protective effect;Proteins;Rattus;receptor;receptor binding;Recombinants;renal damage;senescence;Serum;Severity of illness;Signal Transduction;Site;Source;Technology;Testing;Therapeutic;therapeutic evaluation;Time;tissue injury;Tissues;tool;Transplantation;Tubular formation;uptake;Variant;Vascular calcification;Virus

PROJECT_TITLE: Design of a bioactive mimetic of soluble klotho for the treatment of chronic kidney disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-B(92)]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Contraception/Reproduction;Endometriosis;Precision Medicine;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Narrative  We propose to develop and use mass spectrometry technologies in conjunction with statistical methods to better understand, detect, and diagnose endometriosis. By leveraging the advantages of the chemical sensitivity and specificity of mass spectrometry with the simplicity, speed, and spatial correlation offered by ambient mass spectrometry techniques, we aim to develop new methods that can improve the diagnosis and management of endometriosis at multiple stages of patient treatment using a large cohort of patient samples. The experiments proposed will explore the molecular differences between eutopic and ectopic endometrium tissues, correlate molecular data with patient phenotypes and disease presentation, advance development of a diagnostic method for endometriosis, and improve the surgical resection of endometriosis lesions in vivo during surgical procedures, leading to new understanding of this disease and offering improved treatment options for patients.

PI_NAMEs: SCHIAVINATO EBERLIN, LIVIA  (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: Abdominal Pain;accurate diagnosis;Advanced Development;Affect;Age;Benign;Biological;Biopsy;Caring;Chemicals;Chronic;Clinical;clinical biomarkers;clinical decision-making;clinical phenotype;Clinical Research;cohort;Data;Detection;Development;Devices;Diagnosis;diagnostic biomarker;Diagnostic Procedure;Disease;disease diagnosis;Electrospray Ionization;Endometrial;endometriosis;Endometrium;eutopic endometrium;Excision;expectation;experimental study;Functional disorder;Goals;Gynecologic;Gynecologic Surgical Procedures;improved;In Situ;in situ imaging;in vivo;Incidence;innovation;insight;ionization;Knowledge;Laparoscopy;Lesion;machine learning algorithm;Manuals;mass spectrometric imaging;Mass Spectrum Analysis;Metabolic;Metabolic Marker;Methods;minimally invasive;Molecular;Molecular Analysis;Molecular Diagnosis;molecular imaging;molecular marker;Molecular Profiling;new technology;noninvasive diagnosis;Operative Surgical Procedures;Pathogenesis;Pathologic;Pathology;Patient Care;patient subsets;Patients;Performance;Phenotype;predictive signature;preservation;Prevalence;Procedures;prospective;protein biomarkers;Proteomics;Quality of life;rapid diagnosis;rapid technique;Recurrent disease;Reporting;reproductive;Robotics;Sampling;Sensitivity and Specificity;specific biomarkers;Specificity;Spectrometry, Mass, Electrospray Ionization;Speed;Statistical Data Interpretation;Statistical Methods;statistics;subfertility;Symptoms;Techniques;Technology;Testing;theories;Time;Tissue imaging;Tissue Sample;Tissues;tool;Training;Translating;treatment strategy;Validation;Woman;Work

PROJECT_TITLE: Molecular Imaging and Diagnosis of Endometriosis using Mass Spectrometry Technologies

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]