NIH_SPENDING_CATS: Biotechnology

PHR: Project Narrative The Xu Lab will persist in its efforts to uncover novel mechanisms for intracellular transport and organelle biology through the continued development and application of next-generation super-resolution microscopy methods. Major topics include intraorganellar diffusion and pH dynamics, anomalous diffusion in the living cell, the structure and physical properties of the ER exit site, the integration of FIB-SEM and super-resolution microscopy for ultrathin organelles, and new methods to quantify protein charge states at the super-resolution level.

PI_NAMEs: XU, KE  (contact)

PROJECT_TERMS: Biogenesis;Biological;Biology;Biophysics;cell behavior;Cell Physiology;Cells;Cellular biology;Charge;Chemicals;Complex;Cytoskeleton;Development;Diffusion;Dimensions;Electrophoresis;empowerment;Intracellular Transport;Maps;Membrane Biology;method development;Methods;Microscopy;Morphology;nanometer resolution;nanoscale;next generation;novel;Organelles;physical property;protein transport;Proteins;Research;Resolution;Role;single molecule;Site;Structure;Subcellular structure;success;superresolution microscopy;synergism;System;Thinness;tool;Tubular formation;ultra high resolution;Work

PROJECT_TITLE: Intracellular transport and organelle biology at the nanoscale: A multidimensional super-resolution approach

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Lung;Pediatric;Rare Diseases

ORG_CITY: CHICAGO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_FIPS: US

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative The pediatric population poses unique challenges for developing diagnostic imaging techniques. I aim to develop and optimize an MRI method that is suitable for all ages, from infants to adults, that will enable physicians to effectively and reliably assess cardiac flow over a patient's lifetime. The technique will be used for evaluating and monitoring patients with congenital heart disease to better understand and manage their disease progression.

PI_NAMEs: WEISS, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: 3-Dimensional;4D MRI;Acceleration;Address;Adult;Age;age related;analysis pipeline;Anesthesia procedures;Arteries;Blood flow;Body Size;Breathing;Bypass;Cardiac;cardiac magnetic resonance imaging;Case Study;Cessation of life;Child;Childhood;Circulation;Clinical;cohort;Complex;Complication;congenital heart abnormality;Data;data acquisition;Development;Diagnostic Imaging;diagnostic tool;Disease Progression;Doppler Echocardiography;Echocardiography;Electrocardiogram;Environment;expiration;Failure;flexibility;Fontan Procedure;General Anesthesia;Goals;Heart;heart function;Heart Rate;Heart Transplantation;hemodynamics;image reconstruction;imaging modality;Imaging Techniques;improved;in vivo;Individual;Infant;Legal patent;Life;Live Birth;Lung;Magnetic Resonance Imaging;Measurement;Measures;Methods;middle age;Monitor;Noise;novel;Operative Surgical Procedures;palliation;Patient Monitoring;Patients;Pattern;pediatric patients;Pediatrics;Phase;Physicians;Physiology;Population;pressure;Procedures;Prospective Studies;Pulmonary artery structure;Pulmonary Circulation;Pulmonary Vascular Resistance;Pulsatile Flow;Radial;reconstruction;recruit;Reproducibility;Resolution;Respiration;respiratory;Route;Running;Sampling;Scanning;Secondary to;Series;Single ventricle congenital heart disease;standard of care;Techniques;temporal measurement;Testing;Time;tool;United States;Validation;Veins;Venous;Viscosity;Work

PROJECT_TITLE: Dual-Venc 5D flow for Assessment of Congenital Heart Disease in Pediatrics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F15-B(20)L]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

ORG_CITY: FAYETTEVILLE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE

ORG_STATE: AR

PHR: PROJECT NARRATIVE Large-scale protein conformational changes play a crucial role in the function of proteins; however, these processes are not well-understood at the molecular level. This project aims at bridging the gap between the computational methods and real-world biological problems by developing and employing enhanced sampling molecular dynamics simulations to study proteins from human fibroblast growth factor to coronavirus spike protein.

PI_NAMEs: MORADI, MAHMOUD  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Address;Algorithms;Binding;Biological;Computing Methodologies;Coronavirus spike protein;Coupled;differential geometry;Fibroblast Growth Factor;Free Energy;Growth Factor;Hand;Human;Influenza Hemagglutinin;Membrane;Methodology;Methods;Molecular;Molecular Conformation;molecular dynamics;Oligopeptides;Physics;Play;Process;Protein Conformation;protein function;Proteins;Protocols documentation;Protons;real world application;Role;Sampling;serotonin transporter;single-molecule FRET;Statistical Mechanics;structural biology;Supercomputing;System;Techniques;Technology;tool

PROJECT_TITLE: Physics-based characterization of functionally relevant protein conformational dynamics


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Data Science;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Patient Safety;Pediatric;Prevention;Stroke

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: The silent development and progression of neurologic morbidity, or neuromorbidity, among hospitalized, critically ill patients represents a newly recognized and emerging epidemic. Despite this, no standard clinical tool exists to identify patients at risk for neuromorbidity or for real-time neurologic monitoring, in stark contrast to the heart, kidney, liver, and many other organs. To fill this gap and transform the way clinicians detect and monitor for evolving brain injury, we propose to validate and deploy a bio-digital process for 24/7 point-of-care neurologic monitoring for early detection of neuromorbidity in critically ill patients.

PI_NAMEs: AU, ALICIA K;CLARK, ROBERT S B (contact);HOCHHEISER, HARRY S;HORVAT, CHRISTOPHER MICHAEL

PROGRAM_OFFICER_NAME: HARTMAN, ADAM L

PROJECT_TERMS: Acute;Acute Respiratory Distress Syndrome;Address;Admission activity;Adult;Age;Automobile Driving;Biochemical;Biological;Biological Assay;Biological Markers;biomarker identification;biomarker signature;Blinded;Brain;Brain Injuries;Caring;Cerebral Edema;Cerebral hemisphere hemorrhage;Cessation of life;Characteristics;Childhood;Clinical;clinical diagnosis;Clinical Management;cohort;Consultations;Coupled;COVID-19;Critical Illness;Critically ill children;Data;data pipeline;Data Set;Dedications;Delirium;Detection;Development;Diagnosis;digital;Disease;Early Diagnosis;Elderly;Electronic Health Record;Encephalopathies;Enrollment;Equipment and supply inventories;Fast Healthcare Interoperability Resources;Feeds;Focus Groups;Friends;functional status;Future;Gender;Heart;Hospitalization;Hospitals;Immobilization;Impaired cognition;Incidence;Infant;Inflammatory;Informatics;Infrastructure;Intensive Care Units;interoperability;Intracranial Hemorrhages;Kidney;Kidney Failure;Laboratories;Link;Liver;Liver Failure;Machine Learning;machine learning method;Malignant Neoplasms;Mechanics;Modeling;Monitor;Morbidity - disease rate;neonate;Neurologic;neuromuscular;neurotropic;new epidemic;Organ;Organ failure;Patient Admission;Patients;Pediatric Hospitals;Pediatric Intensive Care Units;Performance;Persons;Pharmaceutical Preparations;Physiological;point of care;Predictive Analytics;prevent;Process;prospective;prototype;Quality of life;Race;rapid detection;Risk;Sampling;Seizures;Sepsis;Serum;side effect;specific biomarkers;Stroke;support tools;Testing;Time;tool;usability;Validation;vector;Virus Diseases

PROJECT_TITLE: Bio-digital Rapid Alert to Identify Neuromorbidity


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Services;Mental Health;Prevention

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Sustained retention in HIV care is a critical determinant of viral suppression for the 26 million people living with HIV in sub-Saharan Africa, but many frequently transition in and out of care over time, potentially contributing to viremia, drug resistance, transmission, and overall morbidity and mortality. The proposed research seeks to 1) assess patient and healthcare worker needs and preferences for strategies to strengthen reengagement in HIV care and 2) use human centered design to develop and pilot a multicomponent strategy to optimize care delivery and support long-term engagement among patients returning to HIV care after loss to follow-up. This research agenda will lead to a full-scale cluster randomized trial to assess this reengagement strategy to improve long- term patient outcomes and prevent ongoing lost to follow-up in this high-risk patient population, a critical global public health priority.

PI_NAMEs: MODY, AALOKE  (contact)

PROGRAM_OFFICER_NAME: POLLARD-BRANCHARD, SUZANNE LEE

PROJECT_TERMS: Address;Adherence;Africa South of the Sahara;Aftercare;Attitude;Back;Behavior;behavior change;care delivery;Caring;Clinic;Clinical;Cluster randomized trial;Collaborations;Consolidated Framework for Implementation Research;Counseling;critical period;Data;design;Development;Drug resistance;Effectiveness;effectiveness/implementation hybrid;Ensure;evidence base;experience;experimental study;Feedback;Focus Groups;follow-up;Foundations;Future;Health;Health Personnel;Health system;high risk;high risk population;HIV;Home;Human;human centered design;implementation evaluation;implementation strategy;improved;improved outcome;Individual;Infectious Diseases Research;Interruption;Intervention;intervention mapping;Interview;Lead;Leadership;Life Experience;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;Nurses;Outcome;patient population;Patient-Focused Outcomes;Patients;peer;Persons;Physicians;Population;preference;prevent;Process;programs;Protocols documentation;prototype;Provider;Psychosocial Factor;public health priorities;Qualitative Methods;Reporting;Research;Research Infrastructure;Research Personnel;response;rural health clinic;service delivery;Services;Structure;Testing;Time;Training;transmission process;Travel;Universities;Viral;Viral Load result;Viremia;Washington;Zambia

PROJECT_TITLE: Optimizing Care Delivery to Support Reengagement in PLWH Returning to HIV Care after Treatment Lapses in Zambia

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Regenerative Medicine;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE Glial cells play a crucial role in the pathological changes in both vascular dementia and Alzheimer’s disease. Dysfunction and/imbalance of microglial immunometabolism and phagocytosis contributes to cognitive decline. This study investigates role of Na/H exchanger in regulation of microglial phagocytosis and immunometabolism and its impact on post-stroke brain repair and cognitive function recovery.

PI_NAMEs: SUN, DANDAN  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acceleration;Alzheimer's Disease;Alzheimer's disease related dementia;Apolipoprotein E;Axon;Biogenesis;Biological Assay;Brain;brain repair;brain tissue;Cell Physiology;Cholesterol;cognitive function;Diffusion Magnetic Resonance Imaging;Disease associated microglia;Energy Metabolism;Enzymes;Event;Exhibits;Functional disorder;Genes;Genetic Transcription;Genus Hippocampus;Glycolysis;Goals;Homeostasis;Hydrolysis;Image;Impaired cognition;improved;Inflammation;Inflammatory;Ischemic Stroke;Knowledge;Lead;lipid metabolism;Luciferases;Mediating;Metabolism;metabolomics;Microglia;Mitochondria;Mus;Myelin;NADPH Oxidase;Nerve Degeneration;Nervous System Physiology;neurobehavioral;Neurodegenerative Disorders;Neuroglia;new therapeutic target;novel therapeutic intervention;Outcome;Oxidative Phosphorylation;Pathologic;Pathway interactions;Phagocytosis;Play;post stroke;protein aggregation;Protein Isoforms;Proteins;Recovery of Function;Regulation;remyelination;repair function;Reporting;Research;Respiration;response;Role;RXR;single-cell RNA sequencing;Stress Tests;Stroke;Synapses;Testing;therapeutic target;tissue repair;Tissues;transcriptome;transcriptome sequencing;transcriptomics;TREM2 gene;Vascular Dementia;Vertebral column;Warburg Effect

PROJECT_TITLE: Na/H Exchanger in Microglial Metabolism and Function

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ORG_CITY: LITTLE ROCK

ORG_NAME: ARKANSAS CHILDREN'S HOSPITAL RES INST

PHR: PROJECT NARRATIVE Lymphatic malformations are congenital anomalies that can cause significant or life-threatening morbidity due to infiltration and compression of critical structures. Targeting Angiopoietin-2, a vital lymphatic growth factor, may have the potential to reverse the abnormal phenotype of lymphatic malformation endothelial cells and would have a substantial impact on the field given current therapeutic limitations. The goal of this project is to identify novel mechanisms underlying lymphatic malformation endothelial cell dysfunction which may provide suitable targets for the development of deliverable, molecular therapeutics for the treatment of lymphatic malformations.

PI_NAMEs: SUN, RAVI  (contact)

PROJECT_TERMS: alpelisib;Anatomy;Angiopoietin-2;Automobile Driving;Biological Assay;Biology;Blood;Blood Vessels;cadherin 5;career;Cell Physiology;Cell Proliferation;clinical practice;Complex;congenital anomaly;Data Set;Dermal;Development;differential expression;Down-Regulation;Endothelial Cells;Environment;Excision;Exclusion;Functional disorder;gain of function;gain of function mutation;Goals;Growth;Growth Factor;Homeostasis;Human;immunocytochemistry;improved;Infiltration;Inflammation;inhibitor;insight;Integrins;Investigation;knock-down;Laboratories;Lesion;Life;Liposomes;Lymphangiogenesis;Lymphatic;lymphatic development;Lymphatic Endothelial Cells;lymphatic malformations;Lymphatic Metastasis;lymphatic vessel;Mediating;Mediator;Mentors;Messenger RNA;MicroRNAs;migration;miRNA expression profiling;Molecular;Molecular Biology;Morbidity - disease rate;mRNA sequencing;multidisciplinary;Multiomic Data;multiple omics;mutant;Mutation;new therapeutic target;novel;Nuclear;Operative Surgical Procedures;Outcome;overexpression;Pain;Pathogenesis;Pathway interactions;Permeability;pharmacologic;Phenotype;Phosphorylation;Physicians;PIK3CA gene;PIK3CG gene;Plasmids;Play;posttranscriptional;primary lymphedema;Proliferating;protein expression;Proteins;Proteomics;Receptor Protein-Tyrosine Kinases;Recurrence;Regulation;Role;Scientist;Sclerotherapy;Signal Transduction;Sirolimus;Small Interfering RNA;Structure;Systems Biology;targeted treatment;Testing;Therapeutic;therapeutic target;Training;transcription factor;Transfection;translational medicine;Tube;Up-Regulation;Vascular Endothelial Cell;Vascular Permeabilities;Western Blotting

PROJECT_TITLE: Altered miRNA Expression Drives Proliferation of Lymphatic Malformation by Activating Pro-Growth Signaling Cascades


ADMINISTERING_IC: TR

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Rural Health;Social Determinants of Health;Vaccine Related

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative Page 303

PI_NAMEs: CASTRO, MARIO  (contact);LEEDER, JAMES STEVEN

PROGRAM_OFFICER_NAME: KRASNOVA, IRINA N

PROJECT_TERMS: Acceleration;Address;Adopted;AstraZeneca COVID-19 vaccine;Biological Markers;career development;Career Mobility;catalyst;Child;Cities;Clinical Informatics;Clinical Research;Clinical Sciences;Clinical Trials;Clinical Trials Unit;Collaborations;collaborative approach;Communication;Communities;community organizations;community partners;Conduct Clinical Trials;County;COVID-19;COVID-19 pandemic;COVID-19 pathogenesis;COVID-19 testing;COVID-19 therapeutics;COVID-19 treatment;COVID-19 vaccine evaluation;Creativeness;Data;Data Set;Decision Making;design;Development;Diagnostic;Discipline;Disease;Diverse Workforce;Ensure;Environment;Equity;Exclusion;experience;Fostering;frontier;Funding;Genomic medicine;Genomics;Goals;Grant;Health;health care quality;health disparity;health equity;Health Priorities;Health system;Healthcare;Healthcare Systems;Hospitals;Human;human subject;improved;Individual;Informatics;Infrastructure;innovation;Institution;Intervention;Intervention Trial;Investments;Kansas;Knowledge;Latinx;Leadership;Learning;life span;Maps;Measures;Medical center;Methods;Midwestern United States;Mission;Missouri;multi-component intervention;nano;novel;patient advocacy group;Patients;point of care;Population;Population Heterogeneity;preventive intervention;programs;Public Health;RADx Underserved Populations;Rare Diseases;recruit;Research;Research Design;Research Methodology;Research Personnel;Resources;response;Rural;Rural Community;Safety;SARS-CoV-2 infection;Science;Structure;symposium;Therapeutic Intervention;TNFSF15 gene;tool;Training;Translating;Translational Research;Underrepresented Populations;Universities;vaccine trial;Vision;Work;Workforce Development

PROJECT_TITLE: Frontiers Clinical and Translational Science Institute at the University of Kansas


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

ORG_STATE: OH

PHR: Stroke affects upwards of 800,000 Americans every year and has an enormous impact on the well-being of the American veteran population with 6,000 new stroke admissions every year. Many of these stroke survivors are living with walking disabilities. Gait problems result in inability to function independently, high risk of falls and poor quality of life. Unfortunately, current gait rehabilitation treatments are limited and many stroke survivors do not achieve full recovery. Therefore, it is critical to develop new approaches to enhance gait rehabilitation methods. We propose to evaluate a brain stimulation treatment called transcranial Direct Current Stimulation (tDCS) that can be added to physical therapy. tDCS has been applied for arm rehabilitation after stroke with positive results, but gait-related investigations are lacking. We will test whether simultaneous tDCS and gait training produces greater improvement in walking abilities than gait training alone. Adjunct tDCS therapy may improve outcomes, and reduce cost of both rehabilitation and post-stroke care. !

PI_NAMEs: PUNDIK, SVETLANA  (contact)

PROJECT_TERMS: Activities of Daily Living;Address;Admission activity;Affect;American;Anodes;Area;arm;Bilateral;Brain;Brain Stem;Caregivers;Caring;Chronic;chronic stroke;Clinical;clinically significant;Cohort Studies;Communities;Corticospinal Tracts;cost;Cross-Over Studies;Data;density;Dependence;design;Diffusion Magnetic Resonance Imaging;disability;Distal;effectiveness study;Electrodes;Enrollment;Equilibrium;Exhibits;fall risk;falls;follow-up;Functional Magnetic Resonance Imaging;Future;Gait;gait rehabilitation;Gait speed;high risk;Impairment;improved;improved outcome;Individual;insight;Intervention;Intervention Studies;Investigation;Ipsilateral;kinematics;Lesion;Limb structure;Lower Extremity;Measures;meter;Methods;military veteran;Minor;Modeling;Motor;Motor Cortex;Motor Evoked Potentials;motor impairment;motor learning;Motor output;motor recovery;Movement;multidisciplinary;neurological rehabilitation;Neuronal Plasticity;neurophysiology;noninvasive brain stimulation;novel;novel strategies;novel therapeutic intervention;Outcome Measure;Paresis;Pathway interactions;patient population;Performance;Peripheral;Personal Satisfaction;Physical therapy;Pilot Projects;post stroke;Predictive Factor;primary outcome;Protocols documentation;Quality of life;Randomized;randomized, controlled study;Randomized, Controlled Trials;Reaction;Recovery;recruit;Recurrence;Rehabilitation Outcome;Rehabilitation therapy;Research Design;Residual state;response;Rest;Safety;secondary outcome;Sensory;spatiotemporal;Stroke;stroke rehabilitation;stroke survivor;Technology;Testing;Therapeutic;Time;tool;Training;transcranial direct current stimulation;treadmill;Upper Extremity;virtual reality environment;Walking

PROJECT_TITLE: Transcranial Direct Current stimulation for post-stroke gait rehab

STUDY_SECTION_NAME: Brain Health and Injury[RRD1]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Networking and Information Technology R&D (NITRD)

ORG_DEPT: PHYSICS

ORG_NAME: ILLINOIS INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE The biological functions of proteins and nucleic acids is a result of both their three-dimensional structure and their conformational dynamics. In this work, computer simulations are utilized to explore and quantify these dynamic properties, as well as how they are linked to the function and regulation of biomolecular complexes. Specific projects will provide a basis for how dynamics affect DNA condensation and gene expression in chromatin fibers, the molecular mechanisms of heme extraction by Gram-positive bacteria, how synthetic peptide-mimics interact with the outer membrane of Gram-negative bacteria, and how experimental small angle X-ray scattering experiments can be interpreted to better understand the structure/function/dynamics relationship in diverse biomolecular complexes.

PI_NAMEs: WERESZCZYNSKI, JEFFERY  (contact)

PROJECT_TERMS: Address;Affect;Area;Award;Bacteria;Biological Process;Chromatin Fiber;Chromatin Remodeling Factor;Collaborations;Complex;Computational Technique;Computer Simulation;Computing Methodologies;computing resources;Dimensions;DNA;Epigenetic Process;experimental study;Fostering;Foundations;Future;Gene Expression;Gene Expression Regulation;Goals;Gram-Negative Bacteria;Gram-Positive Bacteria;Heme;Human;improved;insight;Iron;Knowledge;Length;Link;Membrane;Methods;Modeling;Molecular;Molecular Biology;Molecular Conformation;Nucleic Acids;Nucleosomes;peptidomimetics;Physical condensation;Prevention;Property;protein function;Regulation;Retinal blind spot;Roentgen Rays;Scientific Inquiry;Series;Structure;synchrotron radiation;synergism;synthetic peptide;Techniques;three dimensional structure;Time;Virulence Factors;Work

PROJECT_TITLE: Probing the Structure/Function/Dynamics Relationship in Biomolecular Complexes with Multiscale Computational Techniques

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: Murray

ORG_NAME: IHC HEALTH SERVICES, INC.

ORG_STATE: UT

PHR: PROJECT NARRATIVE: The proposed multi-site cluster randomized controlled trial will use a hybrid-type 2 implementation- effectiveness design to evaluate the effectiveness and implementation outcomes of two low-cost pragmatic interventions of different intensities to increase prescribing of recommended short antibiotic durations (5 days) for acute otitis media for children 2 years of age and older. Mixed-methods will be used to compare a High- intensity intervention comprised of provider education, electronic health record (EHR) changes, and individualized provider audit and feedback with peer comparison to a Low-intensity intervention comprised of provider education and EHR changes.

PI_NAMEs: FROST, HOLLY  (contact)

PROGRAM_OFFICER_NAME: HENDERSON, SUSAN

PROJECT_TITLE: RELAX: Reducing Length of Antibiotics For Children With Ear Infections

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research;Pediatric;Prevention

ORG_CITY: SAN FRANCISCO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Constructing a Community of Teen Health Science Leaders (THSL) will build teens’ knowledge and understanding of cutting-edge NIH-funded research that underlies the health recommendations on topics that are highly relevant to adolescents. The program will provide high school students with the evidence-based rationale for making health positive decisions and promoting better health in both the short and long term. THSL will recruit and work intensively with teens from backgrounds underrepresented in the biomedical sciences, developing these students as teen health science leaders in their community with the goal of increasing these students’ belonging in science, ultimately increasing their interest in and persistence to careers in the health sciences.

PI_NAMEs: NIELSEN, KATHERINE M (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Adolescent;Area;Behavior;California;career;Collaborations;Communities;Community Health Education;Control Groups;design;evidence base;Faculty;Festival;Funding;Goals;Grant;Health;Health behavior;Health education;Health Professional;Health Promotion;Health Sciences;High School Student;instrument;interest;Intervention;Journals;Knowledge;Lead;Leadership;Learning;Life;Measures;Participant;peer;Peer Review;Persons;programs;Public Health;Publishing;Recommendation;recruit;Research;Research Personnel;response;San Francisco;Science;science education;skills;social media;STEM career;STEM field;Student Selections;Students;Surveys;symposium;Teenagers;Testing;United States National Institutes of Health;Universities;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Hematology;Orphan Drug;Osteoporosis;Pain Research;Rare Diseases;Sickle Cell Disease

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Osteonecrosis of the femoral head is a prevalent skeletal complication of sickle cell disease that causes severe chronic pain and significant disability. Low bone density, another prevalent skeletal manifestation of sickle cell disease, co-occurs with osteonecrosis and may further exacerbate chronic sickle cell pain. Repurposing alendronate, an inexpensive oral drug that inhibits bone resorption and is FDA-approved for treatment of osteoporosis (or severe low bone density), as a non-opioid treatment of femoral head osteonecrosis may alleviate pain, increase mobility and improve the health-related quality of life of adults living with sickle cell disease.

PI_NAMEs: ADESINA, OYEBIMPE OLUYEMISI (contact)

PROGRAM_OFFICER_NAME: FRANK, DANIEL J

PROJECT_TERMS: Acute;Adherence;Adolescent;Adult;Adverse event;Affect;Age;Alendronate;Analgesics;arm;Arthralgia;Biological Markers;bisphosphonate;Blood flow;bone;Bone Density;Bone Diseases;Bone necrosis;Bone Pain;Bone Resorption;Bone Resorption Inhibition;bone turnover;California;career;Child;Childhood;Chronic;chronic pain;Clinical;clinical efficacy;Clinical Investigator;clinical translation;cohort;Complication;Cyclophosphamide;Data;disability;effective therapy;Enrollment;FDA approved;Feasibility Studies;femur head;Genotype;Goals;Headache;health related quality of life;Hematopoietic Stem Cell Transplantation;hip surgery;improved;Incidence;insight;ischemic injury;Knowledge;Lifelong disability;Link;Measurement;Measures;medication compliance;meetings;Multicenter Studies;non-opioid analgesic;Operative Surgical Procedures;opioid use;Oral;Oral cavity;Osteogenesis;Osteoporosis;Outcome Measure;Pain;Pain management;pain relief;pain score;Patient Outcomes Assessments;Patients;Persons;Pharmaceutical Preparations;Phase;Phase II Clinical Trials;Phenotype;Physical therapy;post-transplant;Predisposition;prevent;primary endpoint;programs;Prospective cohort;Proxy;Public Health;Quality of life;Questionnaires;randomized placebo controlled trial;recruit;Replacement Arthroplasty;Reporting;Research;Research Project Grants;retention rate;Roentgen Rays;Safety;secondary endpoint;Serum;sex;Sickle Cell;Sickle Cell Anemia;side effect;skeletal;skill acquisition;skills;Specimen;Steroids;Study Subject;Surrogate Markers;Symptoms;System;targeted treatment;Testing;Therapeutic;Time;Training Programs;Translational Research;translational study;Transplant Recipients;transplantation therapy;Trauma;Type I Procollagen;Urine;Vertebral column;Vitamin D;Work

PROJECT_TITLE: A feasibility study of alendronate therapy for osteonecrosis of the femoral head in adults with sickle cell disease

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Narrative The Core grant provides ongoing support to the vision science research community on the UC Berkeley campus, engaged in a broad range of research of the eye and visual system - from basic mechanisms of vision through translation and application of new therapies to people with vision disorders.

PI_NAMEs: KRAMER, RICHARD H (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Animal Model;Animals;Bioinformatics;Brain;Cells;Cellular biology;Collaborations;Communities;Core Grant;Cost Sharing;Data;Dedications;density;design;Discipline;Ensure;Eye;Eye diseases;Faculty;Functional Imaging;Funding;Gene Delivery;Genes;Genetic;Genomics;Gifts;Grant;Human;imaging facilities;imaging modality;Individual;interest;large datasets;member;Microscope;microscopic imaging;Molecular;Molecular Biology;Names;Neurosciences;novel therapeutics;optical imaging;Optometry;Pathology;Persons;Physiology;Principal Investigator;Psychophysics;Recording of previous events;Reporter;Research;Research Personnel;Resource Sharing;Resources;Retina;Schools;Scientist;Seminal;Services;success;Tissues;transcriptomics;Transgenic Animals;Translations;Viral Vector;Vision;vision development;Vision Disorders;Vision research;vision science;Visual Fields;Visual Perception;Visual System;Visualization

PROJECT_TITLE: UC Berkeley Vision Science CORE


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Eye Disease and Disorders of Vision;Neurosciences

PROJECT_TERMS: Animal Model;Animals;Bioinformatics;Brain;Cells;Cellular biology;Communities;Core Grant;Cost Sharing;Data;Dedications;density;design;Discipline;Ensure;Eye;Eye diseases;Faculty;Functional Imaging;Funding;Gene Delivery;Genes;Genetic;Genomics;Gifts;Grant;Human;imaging facilities;imaging modality;Individual;interest;large datasets;member;Microscope;microscopic imaging;Molecular;Molecular Biology;Names;Neurosciences;novel therapeutics;optical imaging;Optometry;Pathology;Persons;Physiology;Principal Investigator;Psychophysics;Recording of previous events;Reporter;Research;Resource Sharing;Retina;Schools;Scientist;Seminal;Services;success;Tissues;transcriptomics;Transgenic Animals;Translations;Viral Vector;Vision;vision development;Vision Disorders;Vision research;vision science;Visual Fields;Visual Perception;Visual System;Visualization

PROJECT_TITLE: Administrative


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurosciences

PHR: Narrative Gene Delivery Core The Gene Delivery Core will serve the UC Berkeley Vision Science community by designing and producing viral vectors, introducing new gene delivery technologies to users, and assisting researchers in generating transgenic animal models.

PI_NAMEs: GONG, XIAOHUA  (contact)

PROJECT_TERMS: Acceleration;Address;Age;Animal Model;base editing;Brain;Capsid;cell type;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communities;Complex;Consumption;CRISPR/Cas technology;Custom;Degenerative Disorder;design;Development;Directed Molecular Evolution;Engineering;Eye;Eye diseases;Fostering;Funding;Gene Delivery;gene delivery system;gene editing technology;Gene Expression;Gene Proteins;gene therapy;Genes;Genetically Engineered Mouse;Genome engineering;Goals;improved;In Vitro;in vivo;Individual;invention;knock-down;Knock-in Mouse;Knock-out;Mammals;Mediating;member;Mouse Strains;Mus;new technology;novel;optogenetics;Pathology;Physiology;Play;prime editing;Production;Productivity;Proteins;Research;Research Personnel;response;restoration;Retina;Role;Services;Site;System;Technology;Therapeutic Studies;Time;Tissues;Transgenic Animals;Transgenic Organisms;Variant;Viral;Viral Vector;Vision;Vision research;vision science;Visual System

PROJECT_TITLE: Gene Delivery


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Neurosciences

PHR: Narrative Optical Imaging Core The Optical Imaging Core will serve the UC Berkeley Vision Science community by introducing and training investigators into the world of advanced optical techniques, assisting investigators in customizing their own imaging equipment for new uses, and assist investigators in assembling sophisticated imaging systems from component parts, including confocal and 2-photon microscopes.

PI_NAMEs: FELLER, MARLA  (contact)

PROJECT_TERMS: adaptive optics;Animals;Biological Assay;Cells;Communities;computerized data processing;cost;cost effective;Custom;design;detector;Equipment;Experimental Designs;experimental study;Eye;Fluorescent Probes;Gifts;Goals;Holography;Human;Image;image processing;imaging modality;imaging system;Imaging technology;improved;in vivo;instrument;instrumentation;investigator training;Ion Channel;Length;Light;Lighting;Measures;Methods;Microscope;Microscopic;microscopic imaging;Microscopy;Modality;Modernization;neural;neuroregulation;new technology;optical imaging;Optics;optogenetics;Paper;Pattern;Pharmacology;Photons;Publications;repaired;Research;Research Personnel;Resources;Retina;Scientist;Services;Sorting;Specialist;Specific qualifier value;Structure;Subcellular structure;System;tallow;Technical Expertise;Techniques;Technology;Tissue imaging;Tissues;tool;Translations;two photon microscopy;two-photon;Vision;vision science;Visual System;visual tracking;Work;Writing

PROJECT_TITLE: Microscopic Imaging


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: HEALTH RELEVANCE: The advent of newborn screening for severe combined immunodeficiency (SCID), coupled with new genome- wide analysis and editing capabilities, constitutes an unprecedented opportunity to establish by direct testing how human genetic sequences control immune cell development, and ultimately to treat SCID by genome editing of causal mutations in patient cells. Our comprehensive program will address the major challenges that must be overcome to capitalize on this transformative opportunity.

PI_NAMEs: MARSON, ALEXANDER  (contact);PUCK, JENNIFER M.

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Animal Model;Autologous;Bioinformatics;Biological Assay;Blood;California;Candidate Disease Gene;candidate identification;Caring;causal variant;CD34 gene;Cells;Clinical;Clinical Data;Clustered Regularly Interspaced Short Palindromic Repeats;Code;congenital immunodeficiency;Country;Coupled;deep sequencing;Defect;Development;Diagnosis;differentiation in vitro;disease-causing mutation;DNA;Doctor of Philosophy;Dryness;Elements;Etiology;Excision;exome;exome sequencing;Exons;Feedback;Fox Chase Cancer Center;gene discovery;Gene Expression Profile;Genes;Genetic;genetic manipulation;genetic variant;genome editing;genome sequencing;genome-wide analysis;genomic data;Genomic Segment;Genomics;Goals;Health;Hematopoietic stem cells;Human;Human Genetics;human model;human pluripotent stem cell;Immune;Immune System Diseases;Immunology;in vitro Model;Infant;Inherited;insight;Investigation;Ligands;Literature;Lymphopenia;Maps;Mature T-Lymphocyte;Medical;Methods;Microspheres;Molecular;mutant;Mutation;Neonatal Screening;notch protein;novel;novel strategies;novel therapeutic intervention;Output;Parents;Patients;Phenotype;population based;Procedures;programs;rapid growth;Resolution;Resources;RNA analysis;San Francisco;screening;Severe Combined Immunodeficiency;Spottings;stem cell differentiation;T-Cell Development;T-Cell Immunodeficiency;T-Cell Receptor;T-Lymphocyte;Testing;therapeutic genome editing;Thymus Gland;tool;transcriptome;transcriptome sequencing;Universities;Untranslated RNA;Validation;Variant;whole genome;Work;Zebrafish

PROJECT_TITLE: Inherited T cell defects: Diagnosis, Mechanisms and Treatments


NIH_SPENDING_CATS: Biotechnology;Genetics

PI_NAMEs: MARSON, ALEXANDER  (contact)

PROJECT_TERMS: Bioinformatics;California;candidate identification;Collaborations;Communication;Complex;Defect;Diagnosis;disease-causing mutation;Ensure;Evaluation;experience;Foundations;genetic variant;genome editing;Genomics;Goals;Grant;Individual;informatics infrastructure;Infrastructure;Inherited;Leadership;Mission;Monitor;Occupational activity of managing finances;participant enrollment;Patients;pediatric department;personalized approach;Principal Investigator;programs;Research Personnel;Research Project Grants;Resources;Sampling;San Francisco;synergism;System;T-Lymphocyte;Universities;Validation;Work

PROJECT_TITLE: Administrative Core


PHR: Relevance to public health. Gene regulation is largely defined by the interactions between different epigenetic marks under the genetic context within the cells. To understand the gene regulation in heterogeneous tissues, we propose to develop several computational methods and experimental assays in single-cell multi-omics. My long-term goal is to understand gene regulation from genetic variations to phenotypic variations, which will eventually pave the road for the discovery of drug targets and early intervention strategy for the different complex diseases.

PI_NAMEs: LIU, YAPING  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 3-Dimensional;Academic Training;Address;Aliquot;Binding;Biological Assay;cell type;Cells;Complex;Computing Methodologies;Cultured Cells;design;Development;Disease;DNA Methylation;Drug Targeting;Early Intervention;Epigenetic Process;epigenomics;experimental study;Gene Activation;Gene Expression;Gene Expression Regulation;gene repression;Genetic;genetic variant;Genetic Variation;Genome;Genomics;Goals;histone modification;individual variation;infancy;Intervention;Knowledge;Maps;Measurement;Measures;method development;Modification;multidisciplinary;multiple omics;Pathologic;Phenotype;predictive modeling;Protocols documentation;Public Health;Role;Sampling;single cell sequencing;single-cell RNA sequencing;Techniques;Technology;Tissues;transcription factor;transcriptomics;Variant

PROJECT_TITLE: Method Development for Single-Cell Multi-omics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: BRENNER, STEVEN E (contact)

PROJECT_TERMS: Administrator;analysis pipeline;Bioinformatics;Cells;Code;Collaborations;Communities;Computer Analysis;Computer software;Computer Systems;computing resources;Creativeness;CRISPR screen;Data;Data Analyses;Data Provenance;Data Security;Data Set;data sharing;Databases;Defect;Deposition;design;Diagnosis;Environment;experimental study;firewall;gene correction;Genes;genome analysis;genome sequencing;Human;informatics infrastructure;Information Resources;Inherited;innovation;Licensing;Maps;Memory;Metadata;Modernization;Nature;novel;Nucleic Acid Regulatory Sequences;Ontology;Open Reading Frames;Participant;Patients;Phenotype;Population;Process;programs;Protein Analysis;Protocols documentation;public database;public repository;Qualifying;Quality Control;Reproducibility;Research;Research Activity;Research Personnel;Resources;RNA;RNA Sequences;Secure;Site;software infrastructure;Specialist;Specificity;Statistical Methods;System;T-Lymphocyte;Transcript;transcriptome;transcriptome sequencing;Variant;whole genome

PROJECT_TITLE: Informatics Infrastructure and Bioinformatics Analysis


NIH_SPENDING_CATS: Data Science;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD);Neurosciences

PHR: Narrative Bioinformatics Core The Bioinformatics Core will serve the UC Berkeley Vision Science community by establishing cloud-based pipelines for pre-processing, storage and retrieval of high-throughput single-cell transcriptomics and imaging data, developing, and maintaining bioinformatic pipelines to support downstream analysis of new and publicly available datasets, and providing advisory and training services to investigators on bioinformatic methods.

PI_NAMEs: GRONERT, KARSTEN  (contact)

PROJECT_TITLE: Bioinformatics


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetic Testing;Genetics;Human Genome;Infant Mortality;Pediatric;Precision Medicine;Primary Immunodeficiencies;Rare Diseases

PI_NAMEs: PUCK, JENNIFER M. (contact)

PROJECT_TERMS: Affect;Aliquot;Animal Model;Archives;Artemis deficiency;B-Lymphocytes;Bioinformatics;Blood;Blood specimen;Case Report Form;CD34 gene;Cell Count;Cell Line;Cell Physiology;Cell Survival;Cells;Clinical;Clinical Data;clinically relevant;Code;congenital immunodeficiency;Consent;Consent Forms;CRISPR/Cas technology;Cryopreservation;Data;data de-identification;data exchange;Databases;deep sequencing;Defect;Deposition;Diagnosis;Disease;DNA;DNA sequencing;DNA Sequencing Facility;Dryness;Eligibility Determination;Enrollment;Ensure;Freezing;Functional disorder;gene correction;Genes;Genetic;genetic disorder diagnosis;genetic variant;genome editing;genome sequencing;Genomic DNA;Genomics;Goals;Human;Human Herpesvirus 4;human subject;Immunology;Individual;Informed Consent;Inherited;Institutional Review Boards;Investigation;Lead;Liquid substance;Lymphocyte;Mediating;Neonatal Screening;Nitrogen;novel strategies;Ontology;Parents;Participant;Patients;Peripheral Blood Mononuclear Cell;personalized medicine;Phenotype;phenotypic data;Plasma;population based;programs;Protocols documentation;Provider;public database;Publications;rapid growth;Rare Diseases;Records;Regulation;Research;Research Personnel;RNA;Role;Sampling;Sampling Studies;screening;Secure;Severe Combined Immunodeficiency;Source;Spottings;Standardization;System;T-Lymphocyte;Testing;Training;transcriptome;transcriptome sequencing;transforming virus;United States National Institutes of Health;Untranslated RNA;Validation;Variant;Venous blood sampling;whole genome;X-Linked Severe Combined Immunodeficiency

PROJECT_TITLE: Human Participants and Sequencing


NIH_SPENDING_CATS: Biotechnology;Genetic Testing;Genetics;Human Genome;Primary Immunodeficiencies;Rare Diseases

PROJECT_TERMS: Affect;Alleles;Allogenic;analysis pipeline;Biology;candidate identification;causal variant;Characteristics;clinical practice;Code;computer studies;congenital immunodeficiency;cost;CRISPR screen;Data;data integration;Data Set;Databases;Defect;Deficiency Diseases;Diagnosis;Diagnostic;Disease;disease diagnosis;disease phenotype;disease-causing mutation;Engraftment;Etiology;Event;exome;exome sequencing;Exons;experimental study;Gene Expression Profile;Genes;genetic disorder diagnosis;Genetic Transcription;Genetic Variation;Genome;genome sequencing;Genomics;Goals;Hematopoietic Stem Cell Transplantation;Immunology;Individual;Inherited;insertion/deletion mutation;Internet;Investigation;Messenger RNA;Methods;Molecular;Nucleic Acid Regulatory Sequences;Parents;Pathway interactions;Patients;Phenotype;proband;Proteins;Reporting;Research;Resources;RNA Splicing;Severe Combined Immunodeficiency;Severities;Signal Transduction;Single Nucleotide Polymorphism;T-Cell Development;T-Lymphocyte;Testing;Tissues;trait;transcriptome;transcriptome sequencing;transcriptomic profiling;Untranslated RNA;Validation;Variant;variant of unknown significance;whole genome

PROJECT_TITLE: Identification of Candidate Disease-Causing Variants


ADMINISTERING_IC: DE

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Pediatric

ORG_CITY: PHILADELPHIA

ORG_NAME: OSTIIO LLC

PHR: NARRATIVE Each year, ~200,000 newborns worldwide, 80-85% of whom require surgical intervention, are afflicted with congenital conditions that cause impaired growth of the skull or mandible, leading to abnormalities that affect breathing, hearing, speech, visual function, neurologic development, and mastication. Distraction osteogenesis (DO) is a widely recognized treatment modality for craniofacial abnormalities that harnesses the body’s natural ability to regenerate bone in order to correct skeletal deficiencies and defects. While surgeons have shown the utility of DO for restoring functional discrepancies in patients born with craniofacial differences, the technique has not been widely adopted due to numerous limitations of current DO systems stemming from their semi- buried design and burdensome reliance on caregivers to follow precise treatment protocols. The Ostiio distraction system addresses many of these issues as the first fully subcutaneous, contactless DO system for the CMF skeleton, thereby markedly reducing potential for infection, scarring, and manipulation noncompliance.

PI_NAMEs: DESNOYER, JESSICA  (contact);WES, ARI M

PROGRAM_OFFICER_NAME: GRISIUS, MARGARET

PROJECT_TITLE: A Smart, Fully Subcutaneous Distraction System to Improve Outcomes in Patients with Congenital or Acquired Craniofacial Differences


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

PHR: This Center of Research Translation is focused on understanding the autoimmune disease, systemic sclerosis (SSc) and to better understand the cellular and molecular processes driving this disease when it affects the skin and lungs. Lung complications of SSc are particularly lethal, but recent technological advances are providing new opportunities for understanding the pathologic processes directly from human diseased skin and lung tissues by examining the molecular alterations associated with disease cell-by-cell. Metabolic changes in cells have also recently become better understood to lead to disease and will be investigated in circulating cells known as platelets, as well as through a novel imaging approach. Thus, this Center proposes to better understand the pathogenic pathways driving SSc skin and lung disease through translational studies, identifying informative biomarkers and developing novel targeted therapeutics. The focus of each of the projects on different SSc clinical manifestations, mediators of disease, and drug inhibitors will provide a rich, highly collaborative environment for fundamental discovery within bridging project topics and core resources.

PI_NAMEs: LAFYATIS, ROBERT A. (contact)

PROGRAM_OFFICER_NAME: GREEN PARKER, MELISSA C

PROJECT_TERMS: Affect;Animal Model;Autoimmune Diseases;Automobile Driving;Binding Sites;biobank;Bioinformatics;bioinformatics tool;Biological;Biological Markers;Biological Models;Biology;Blood;Blood Platelets;Blood Vessels;Cell Communication;Cell Energetics;cell type;Cells;Center for Translational Science Activities;Childhood;Chromatin;Clinical;Clinical Data;clinical translation;Clinical Trials;collaborative environment;Connective Tissue;Cutaneous sclerosis;cytokine;Data;data integration;Data Set;Databases;detection method;Development;Disease;Disease Marker;Disease Pathway;drug discovery;Epigenetic Process;epigenomics;experience;Fibroblasts;Fibrosis;gene discovery;Gene Expression;genetic regulatory protein;genomic data;Genomics;Glutaminase;Glutamine;Goals;Heterogeneity;human disease;human tissue;imaging approach;In Vitro;inhibitor;innovation;Interleukin-6;Interstitial Lung Diseases;Lead;Localized scleroderma;Lung;Lung Diseases;Lung Transplantation;Macrophage;Mediating;Mediator;Medical center;medical schools;Metabolic;Metabolism;Modeling;Molecular;Multiomic Data;multiple omics;Myofibroblast;new therapeutic target;novel;novel marker;novel therapeutics;Observational Study;Organ;Oxidative Phosphorylation;Pathogenesis;Pathogenicity;Pathologic Processes;Pathway interactions;Patients;Perfusion;Pharmaceutical Preparations;Phenotype;PIK3CG gene;Population;Positioning Attribute;Positron-Emission Tomography;preclinical study;Process;profibrotic fibroblast;programs;protein expression;Proteomics;Protocols documentation;pulmonary arterial hypertension;Pulmonary Fibrosis;repository;Research Personnel;Resources;Rheumatology;Role;Sclerosis;Serum Markers;single cell technology;single nucleus RNA-sequencing;single-cell RNA sequencing;Skin;skin biopsy;skin disorder;Skin Tissue;Slice;specific biomarkers;Structure of parenchyma of lung;Systemic Scleroderma;Systems Biology;Talents;targeted treatment;Technology;Testing;therapeutic target;Tissues;tool;transcription factor;transcriptome;transcriptomics;Translational Research;translational study;Universities;Vacuolar Protein Sorting;vascular injury

PROJECT_TITLE: Clinical-Translational Studies in Skin, Lung, and Vascular Complications in Systemic Sclerosis


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Human Genome;Orphan Drug;Pediatric;Primary Immunodeficiencies;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Transplantation

PROJECT_TERMS: Address;Allogenic;Autologous;Autologous Transplantation;B cell differentiation;Base Sequence;Benign;Blood;Candidate Disease Gene;candidate identification;Cataloging;causal variant;CD34 gene;Cells;Clinical;Clinical Medicine;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Code;congenital immunodeficiency;course development;CRISPR interference;CRISPR screen;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;deep sequencing;Defect;Deficiency Diseases;design;Development;Diagnosis;disease-causing mutation;DNA;DNA sequencing;Donor person;Elements;Essential Genes;Etiology;exome sequencing;Exons;Family;Fluorescence-Activated Cell Sorting;follow-up;frontier;gene correction;gene discovery;gene therapy;Generations;Genes;Genetic;genetic disorder diagnosis;genetic variant;Genome;genome editing;Genome engineering;genome sequencing;Genomics;Graft Rejection;graft vs host disease;Guide RNA;Hematopoietic stem cells;high throughput technology;Human;human cord blood CD34+ cell;Human Genetics;human pluripotent stem cell;IL2RG gene;Immune;immune function;Immune System Diseases;immunodeficiency;Immunology;Impairment;improved;In Vitro;in vivo;Incidence;Inherited;Knock-out;Knowledge;Laboratories;Lead;Libraries;Link;Lymphoid;Maps;Methods;Molecular;multidisciplinary;Mutate;Mutation;mutation correction;new technology;novel;novel therapeutics;nuclease;Nucleotides;Pathogenicity;Patients;Positioning Attribute;Regulatory Element;Ribonucleoproteins;scalpel;Site;T cell differentiation;T-Cell Development;T-Lymphocyte;Technology;Testing;Therapeutic;therapeutic genome editing;Translating;Untranslated RNA;Variant;whole genome;Writing

PROJECT_TITLE: Editing to Create and Correct Gene Variants


NIH_SPENDING_CATS: Autoimmune Disease;Lung;Orphan Drug;Rare Diseases;Scleroderma

PHR: The CORT Administrative Core will foster a scientific environment that promotes CORT goals advancing understanding of systemic sclerosis pathogenesis, identifying new biomarkers of disease, and discovering novel therapies for patients with SSc. A strong leadership team will organize and manage CORT investigator, project and core activities to promote this mission. An external advisory committee will provide oversight and guidance in new scientific directions..

PROJECT_TERMS: Advisory Committees;Area;Basic Science;Biological Markers;Biology;biomarker identification;Blood Vessels;Boston;Budgets;Clinical;clinical translation;Collaborations;Communication;Critiques;Disease;Ensure;Environment;Evaluation;experience;Fostering;Goals;Grant;Human Resources;Immunology;Individual;Interstitial Lung Diseases;Leadership;Lung;Medicine;meetings;Mentors;Minority;minority investigator;Mission;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;novel therapeutics;organizational structure;Outcome;Pathogenesis;Patients;Physicians;Program Reviews;programs;pulmonary arterial hypertension;Recommendation;Reporting;Research Personnel;Science;Scientist;Site;Skin;skin disorder;System;Systemic Scleroderma;Systems Biology;Time;Translational Research;translational study;Universities;web site


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Lung;Rare Diseases;Scleroderma;Transplantation

PHR: PROJECT NARRATIVE The specific purpose of Core B: Clinical and Biorepository Core is to provide essential linked clinical data with blood, skin and lung biospecimens to facilitate the proposed translational research Projects. The Core will furnish experienced statistical support with both disease and clinical data familiarity to assist in the completion of the three Projects. Through these two aspects Core B will supply the necessary resources to ensure successful completion of the three proposed translational research Projects.

PI_NAMEs: DOMSIC, ROBYN THERESE (contact)

PROJECT_TERMS: Acceleration;Age;Autoantibodies;Autoimmune Diseases;biobank;Biological;Biometry;Blood;Blood Vessels;Cause of Death;Cell model;Cells;Classification;Clinical;Clinical Data;clinical data repository;clinical investigation;clinical phenotype;clinical translation;cohort;Collaborations;Collection;Data;data repository;design;Development;Diffuse Scleroderma;disability;Discipline;Disease;disease model;Ensure;Evaluation;experience;experimental study;Faculty;Familiarity;Generations;Goals;graduate school;Human;human disease;improved;Individual;Institution;Interdisciplinary Study;Interstitial Lung Diseases;Link;Lung;Lung Transplantation;Modeling;Molecular;Morbidity - disease rate;mortality;multidisciplinary;Nature;Organ;Organ Procurements;Pathogenesis;Pathway interactions;Patients;programs;prospective;Protocols documentation;Public Health Schools;Publications;pulmonary arterial hypertension;Recording of previous events;repository;Research;Research Personnel;Research Project Grants;Resources;Rheumatology;Schools;Scleroderma;Serum;single cell analysis;Skin;skin disorder;Skin Tissue;Slice;Specimen;Standardization;Statistical Data Interpretation;Statistical Models;Structure of parenchyma of lung;Study models;System;Systemic Scleroderma;Techniques;Testing;Therapeutic;Therapeutic Intervention;Tissue Model;tissue processing;Tissue Sample;Tissues;Translational Research;translational research program;translational study;Transplantation;Universities

PROJECT_TITLE: Clinical and Biorepository Core


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Infant Mortality;Pediatric;Primary Immunodeficiencies;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

PI_NAMEs: WIEST, DAVID L. (contact)

PROJECT_TERMS: Affect;Bioinformatics;CD34 gene;CD8B1 gene;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Collaborations;CRISPR screen;Defect;Development;Diagnosis;Diagnostic;Disease;disease-causing mutation;DNA Sequence;Elements;Embryo;Embryonic Development;Essential Genes;Etiology;Evaluation;exome sequencing;Expression Profiling;Flow Cytometry;Gene Cluster;Gene Expression Profile;gene product;Genes;Genetic Epistasis;genetic variant;genome editing;genome sequencing;Genomics;Hematopoietic;Hematopoietic stem cells;high throughput analysis;Human;human model;IL2RG gene;IL7R gene;Impairment;In Vitro;in vivo;Individual;Inherited;insight;knock-down;Knowledge;Ligands;Link;loss of function;Maps;member;Messenger RNA;Methods;Microspheres;Modeling;Molecular;Mus;mutant;Neonatal Screening;notch protein;novel;novel therapeutics;Organ;Orthologous Gene;Pathogenesis;Patients;personalized approach;Play;population based;Process;programs;PTPRC gene;Research Personnel;Resolution;Role;screening;Severe Combined Immunodeficiency;single-cell RNA sequencing;stem cell differentiation;stem cell model;stem cells;System;T cell differentiation;T-Cell Development;T-Cell Receptor;T-Lymphocyte;Testing;Transcend;transcriptome;Umbilical Cord Blood;Untranslated RNA;Validation;Variant;whole genome;Zebrafish

PROJECT_TITLE: Functional Analysis of Variants Underlying T Cell Defects


PHR: PROJECT NARRATIVE – Overall As the US population becomes increasingly older and more diverse, the number of Americans with dementia is expected to rise substantially, particularly among those with concomitant vascular disease. The Clinical significance of INciDEntal white matter lEsions on MRI in a Diverse population with cognitive complaints (INDEED) proposes to comprehensively examine the impact of individual and combined MRI measures of white matter injury on cognitive performance among a diverse, non-demented, stroke free population with cognitive complaints over an extended period of observation.

PI_NAMEs: DECARLI, CHARLES  (contact);FORNAGE, MYRIAM

PROGRAM_OFFICER_NAME: GARCIA, LINA FERNANDA

PROJECT_TERMS: Address;African American population;aging process;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer’s disease biomarker;American;Amyloid;Awareness;Biological Markers;Black Populations;Black race;Blood;Blood Vessels;Brain;brain health;Caring;Censuses;cerebrovascular;Characteristics;Clinical;Clinical assessments;clinical phenotype;clinically significant;Cognition;Cognitive;cognitive performance;cohort;Data;Dementia;dementia burden;dementia risk;effective therapy;endothelial dysfunction;Epidemiology;Ethnic Origin;Evolution;executive function;Future;Genetic Predisposition to Disease;Goals;Health;Hispanic;Hispanic Populations;Impaired cognition;inclusion criteria;Individual;Infarction;Inflammation;inflammatory marker;injury burden;Knowledge;late life;Lesion;Life;Location;Magnetic Resonance Imaging;Measures;Mediating;Medical;Memory;Microvascular Dysfunction;Minor;Nerve Degeneration;neuroimaging;non-demented;novel;novel marker;Outcome;Pathology;Patients;Play;polygenic risk score;Population;Population Heterogeneity;precision medicine;Process;Public Health;Race;radiologist;Risk;Risk Factors;risk prediction model;Role;screening;sex;Stroke;Therapeutic Studies;Vascular Cognitive Impairment;Vascular Diseases;vascular risk factor;Water;white matter;White Matter Hyperintensity;white matter injury

PROJECT_TITLE: The Clinical Significance of Incidental White Matter Lesions on MRI Amongst a Diverse Population with Cognitive Complaints (INDEED)


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Immunization;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: STANFORD

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Artificial neural networks have contributed significantly to many areas of medical data science, but they have not been fully explored for 3D protein structure design tasks. This project builds on our existing efforts to develop generative neural network models and engages the challenging issues that face conventional design methods. For their significance in biotechnology and therapeutics today, antibodies provide a rich and diverse venue for developing and applying our cutting-edge protein design technology, and our goals are to achieve fully-automated, epitope-specific antibody design.

PI_NAMEs: HUANG, POSSU  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: 2019-nCoV;3-Dimensional;Acceleration;Address;Adopted;Agonist;Algorithm Design;Antibodies;antibody engineering;Antivenins;APLN gene;Architecture;Area;artificial neural network;Binding;Biotechnology;Cardiac Myocytes;chemokine receptor;Clinical;cluster computing;combinatorial;Complex;Computational algorithm;computational platform;Computing Methodologies;cost;CXCR4 gene;Data;Data Science;deep learning;deep neural network;design;detection platform;Development;Diagnostic tests;Docking;Engineering;Environment;Epitopes;Evolution;Experimental Designs;Face;Fingers;flexibility;G-Protein-Coupled Receptors;Generations;generative adversarial network;generative models;Goals;Home;Image;Immune;Immunoglobulins;improved;interest;interfacial;knowledge base;Learning;Libraries;loss of function;Marketing;Medical;Medical Technology;method development;Methods;model design;Modeling;Modernization;Molecular;Molecular Conformation;molecular recognition;Myocardial Ischemia;nanobodies;neural network;Neural Network Simulation;novel;Outcome;Performance;Play;Positioning Attribute;Probability;Process;programs;Protein Engineering;protein structure;Proteins;receptor;receptor binding;Recording of previous events;Reporting;Research;Research Personnel;response;Role;Sampling;scaffold;Scheme;screening;Side;Signal Transduction;Snake Venoms;Snakes;Specificity;Speed;Structure;Technology;Testing;Therapeutic;Time;tool;Toxin;Training;Variant;Vertebral column

PROJECT_TITLE: Generative neural networks for structure-based antibody design

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Rare Diseases;Scleroderma

PI_NAMEs: SINGH, HARINDER  (contact)

PROJECT_TERMS: Address;Biological;Biological Markers;Blood Vessels;cell type;Cells;Chromatin;Chromatin Remodeling Factor;clinical translation;combinatorial;Complex;complex data;computational suite;computerized tools;Data;Data Set;Decision Trees;dimension reduction;Disease Outcome;Elasticity;Epigenetic Process;Fibroblasts;Functional disorder;gene regulatory network;Gene set enrichment analysis;Genes;Genetic Transcription;Genomics;Goals;Individual;innovation;insight;Logic;Lung;Machine Learning;machine learning model;Modeling;Molecular;Molecular Profiling;multidimensional data;Multiomic Data;multiple omics;Myeloid Cells;novel;Outcome;Pathway interactions;Population;predictive marker;predictive modeling;Process;programs;protein protein interaction;Proteins;Proteomics;random forest;Research Project Grants;Signal Pathway;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Skin;Structure;Systemic Scleroderma;Systems Biology;Testing;Tissue-Specific Gene Expression;Tissues;tool;transcription factor;translational study;Validation;Visualization;Work

PROJECT_TITLE: Systems Biology Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: DECARLI, CHARLES  (contact)

PROJECT_TERMS: Address;Alzheimer's Disease;Ancillary Study;Black race;Budgets;Characteristics;clinical practice;Clinical Trials Design;clinically significant;Cognitive;Collaborations;Communication;comorbidity;Data;Data Analyses;Data Collection;data repository;Data Set;data sharing networks;Dementia;design;Ensure;expectation;experience;flexibility;Funding;Future;Goals;Health;Hispanic;human subject;Impaired cognition;Individual;Infrastructure;innovation;International;Knowledge;Laboratories;Leadership;Lesion;Logistics;Magnetic Resonance Imaging;Manuscripts;Measures;Medical;meetings;Methods;Monitor;multidisciplinary;National Institute of Neurological Disorders and Stroke;neuroimaging;non-demented;organizational structure;Outcome;Output;outreach;Performance;performance site;Persons;Phase;Policies;Population Heterogeneity;Process;programs;Protocols documentation;Publications;Quality Control;Reaction Time;recruit;Research;Research Personnel;Resource Allocation;Resources;Risk;Role;sample collection;Sampling;Science;Scientific Advances and Accomplishments;Scientist;Site;Specific qualifier value;Standardization;Stroke;Structure;success;Teleconferences;timeline;transmission process;United States National Institutes of Health;white matter


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Human Genome;Lung;Rare Diseases;Scleroderma

PHR: Skin fibrosis in systemic sclerosis (SSc) leads to significant morbidity resulting from disfiguring, painful and itchy skin, and joint contractures. We propose to understand at a molecular level the roles different inflammatory and profibrotic cells pay in the skin of SSc patients at a single cell level. We anticipate that our findings will reveal novel insights into the pathways driving the scarring process, and motivate targeted drug development .

PROJECT_TERMS: Adult;Aftercare;ATAC-seq;Automobile Driving;Binding;biomarker identification;Blood Vessels;CCL18 gene;Cells;Child;Chromatin;Chromatin Structure;Cicatrix;Clinical;clinical translation;Collection;Communication;Computing Methodologies;connective tissue growth factor;Contracture;Cutaneous;Cutaneous sclerosis;cytokine;Data;Data Set;Dermal;differential expression;Diffuse;DNA;drug development;Drug Targeting;Epigenetic Process;epigenome;Fibroblasts;FOSL2 gene;FOXP1 gene;functional disability;Gene Expression;Genes;Genome;HIF1A gene;IL-6 inhibitor;Immune;In Vitro;Inflammatory;insight;interest;Interleukin-6;Interstitial Lung Diseases;Joints;knock-down;Link;Localized scleroderma;Lung;Lung Diseases;Macrophage;Macrophage Activation;MADH3 gene;Measures;Mediator;Methodology;Molecular;Morbidity - disease rate;mortality;multiple omics;Myelogenous;Myeloid Cells;Myofibroblast;novel;Pain;Pathogenesis;Pathway interactions;Patients;Phenotype;Population;Predictive Factor;predictive marker;Process;Profibrotic signal;progenitor;Regulon;Rheumatism;Role;Sampling;Severity of illness;SFRP4 gene;Signal Transduction;single cell ATAC-seq;single nucleus RNA-sequencing;single-cell RNA sequencing;Skin;skin biopsy;skin disorder;skin fibrosis;Source;STAT1 gene;Systemic disease;Systemic Scleroderma;Systems Biology;THBS1 gene;tocilizumab;tool;transcription factor;transcriptome;transcriptomics;translational study

PROJECT_TITLE: Cell epigenetics & communication in systemic sclerosis and localized scleroderma skin disease


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative Heart failure is typically preceded by cardiomyocyte hypertrophy. Hypertrophy is regulated by a complex intracellular signaling network which is not targeted by current therapeutics. Computational modeling allows for the discovery and predicted efficacy of drugs that target cardiomyocyte hypertrophy to prevent heart failure.

PI_NAMEs: EGGERTSEN, TAYLOR  (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Address;Agreement;Behavior;Biochemical;Biological;Cardiac;Cardiac Myocytes;career;Cause of Death;Cells;Clinical;Complex;Computer Models;cytokine;Data;Databases;design;Disease;drug action;drug efficacy;Drug Industry;Drug Modelings;drug repurposing;Drug Screening;Drug Targeting;drug testing;Drug usage;experience;experimental study;FDA approved;follow-up;Grant;Growth;Heart;Heart Diseases;Heart failure;Heart Hypertrophy;Hypertension;Hypertrophy;In Vitro;Literature;Mechanical Stress;Mediating;Modeling;Myocardial Ischemia;Neonatal;network models;new therapeutic target;novel;novel therapeutics;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Pharmacology;predictive modeling;prevent;Process;Proteins;Rattus;response;Role;Signal Transduction;simulation;System;Systems Biology;targeted treatment;Testing;Therapeutic;therapeutic target;Training;translational applications;virtual;Work

PROJECT_TITLE: Virtual drug screen reveals context-dependent inhibition of cardiomyocyte hypertrophy


ORG_CITY: SANTA BARBARA

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: Project Narrative Bioelectrochemistry is currently an underused experimental tool that enables to study bioelectrochemical process that cannot be applied by other methods for studying the system's thermodynamic and kinetics. The proposed projects aim to bring new electrochemical techniques to the forefront of studying biological redox reaction. Ultimately, the research proposed is expected to (i) promote a deeper understanding of how single enzymes operate individually, and (iii) develop a new generation of biosensors, potentially stimulating the development of targeted approaches to rapid diagnosis of infectious diseases.

PI_NAMEs: SEPUNARU, LIOR  (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TITLE: Bioelectrochemistry at the Nanoscale: Fundamentals and Applications

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-R(55)R]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Hematology;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Sepsis

ORG_CITY: BATON ROUGE

ORG_DEPT: PATHOLOGY

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: NARRATIVE Sepsis is a global public health threat. Numerous clinical trials have failed to come out with new therapies. Sepsis is a prominent cause of organ dysfunction and failure in adults and children. Lower respiratory tract infections are a vital cause of septicemia/sepsis (aka pneumonia-derived sepsis). The goal of the project is to explore the innate immune mechanisms associated with pneumonia-derived sepsis in order establish new therapies to reduce multiple organ dysfunction and failure.

PI_NAMEs: LE, JOHN  (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Ablation;Adult;Alveolar;Alveolar Macrophages;Antibiotic Resistance;Antibiotics;Bacteria;Bacterial Infections;Binding;Candida albicans;Cause of Death;Cell Physiology;Cells;Chemotaxis;Child;Clinical Trials;common treatment;CXC Chemokines;Cytokinesis;Data;Development;Drug usage;Epithelial Cells;experience;experimental study;extracellular;Faculty;Failure;Family;Foundations;Functional disorder;Goals;Gram-Positive Bacteria;Health Expenditures;High Prevalence;Host Defense;Human;human pathogen;Immune response;Immunocompetent;Immunologic Receptors;immunosuppressed;Immunotherapy;In Vitro;in vivo;Infection;Inflammasome;Inflammation;innate immune mechanisms;Innate Immune Response;insight;Invaded;Knock-out;Knockout Mice;Knowledge;Leucine;Leucine-Rich Repeat;Leukocytes;Ligands;Lower Respiratory Tract Infection;Lung;Lung infections;Macrophage;marenostrin;Mediating;Mediator;Membrane;Mentors;methicillin resistant Staphylococcus aureus;Methods;Morbidity - disease rate;mortality;mouse model;Mus;Myelogenous;Myeloid Cells;National Research Service Awards;Natural Immunity;neutrophil;Neutrophil Infiltration;novel therapeutic intervention;novel therapeutics;Organ;Organ failure;pathogen;Pathogenesis;Pathologic;Phagocytosis;Play;Pneumonia;Population;Positioning Attribute;Predisposition;pressure;Production;Proteins;Public Health;receptor;recruit;Reporting;Research Training;Respiratory Tract Infections;response;Role;sensor;Sepsis;septic;Septicemia;Spleen;Staphylococcus aureus infection;Stromal Cells;System;Testing;tissue injury;Tissues;Toll-like receptors;Up-Regulation;Vaccines

PROJECT_TITLE: NLRP10 Inflamasome in Gram-positive Sepsis


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Hydrocephalus;Neurosciences;Patient Safety;Pediatric;Rare Diseases

ORG_CITY: SALT LAKE CITY

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF UTAH

PHR: Hydrocephalus is a potentially debilitating neurological condition that primarily affects babies under a year of age and has traditionally been treated by inserting a shunt between the brain and the abdomen. A newer endoscopic procedure offers hope of shunt-free treatment that may reduce complications over a child's life, but it is not clear if the endoscopic procedure results in similar intellectual outcome as shunt. We propose, therefore, a randomized trial to compare intellectual outcome and brain structural integrity between these 2 treatments, to help families make the best treatment decision for their baby.

PI_NAMEs: HOLUBKOV, RICHARD ;KESTLE, JOHN  (contact);KULKARNI, ABHAYA V;LIMBRICK, DAVID DELMAR

PROGRAM_OFFICER_NAME: HARDY, KRISTINA KOREN

PROJECT_TERMS: 1 year old;Abdomen;Accounting;Affect;Age;Age Years;American;Anisotropy;Brain;Cauterize;Cerebrospinal Fluid;Cerebrospinal fluid shunts procedure;Cerebrum;Child;Child health care;Childhood;Clinical Research;Cognitive;cohort;Corpus Callosum;Corticospinal Tracts;Data;Development;Diffusion;Diffusion Magnetic Resonance Imaging;Family;Hospital Charges;Hydrocephalus;Image;Infant;insight;Language;Length of Stay;Life;Measures;Methods;Motor;NCAM1 gene;Neurologic;neurosurgery;North America;Operative Surgical Procedures;optimal treatments;Outcome;Pediatric Hospitals;Performance;Postoperative Period;primary outcome;Procedures;Quality of life;randomized trial;Repeat Surgery;Risk;Shunt Device;Structure of choroid plexus;Surveys;tertiary care;Toddler;treatment arm;Treatment Failure;Ventricular;Ventriculostomy;white matter

PROJECT_TITLE: Endoscopic versus Shunt Treatment of Hydrocephalus in Infants

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders K Study Section[NSD-K]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Sleep Research;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BOSTON

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative Seventy million Americans suffer from chronic sleep disturbances and are at a high risk of developing intestinal dysfunction, which can promote acute cardiovascular and cardiometabolic diseases. However, little is known about the fundamental biological molecular, and cellular mechanisms affecting the intestinal tract when sleep is low. This proposal will elucidate the impact of sleep loss on the intestinal tract's cellular composition and function.

PI_NAMEs: LAUREANO RUIZ, ALEJANDRA SOFIA (contact)

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: Acute;Address;Affect;American;Animals;Back;Binding;Biological;Biological Models;Brain;Cardiometabolic Disease;Cardiovascular Diseases;Cause of Death;Cell Differentiation process;cell growth;Cell secretion;Cells;Cessation of life;Chronic;Communication;Compensation;Complex;Data;daughter cell;Disease;Drosophila genus;Enteroendocrine Cell;Event;experimental study;Fellowship;fly;Functional disorder;Future;gastrointestinal epithelium;Genetic;Goals;Health;high risk;Homeostasis;Immunofluorescence Immunologic;Individual;Intestinal Diseases;Intestines;knock-down;Knowledge;Lead;life span;Long-Term Effects;Longevity;Mammals;Mentors;Modeling;Molecular;Molecular Profiling;Neurobiology;nutrient absorption;nutrition;Organ;Oxidative Stress;Pathway interactions;Peptides;Physiology;poor sleep;Population;premature;Process;programs;Proliferating;Reactive Oxygen Species;Recovery;Regenerative capacity;Reporter;Research;response;Risk;Role;Secretory Cell;Sensory;severe injury;Signal Pathway;Signal Transduction;Sleep;sleep behavior;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep quality;sleep quantity;stem cell proliferation;stem cells;Technical Expertise;Testing;tool;tumor growth;Work

PROJECT_TITLE: Understanding the effects of sleep deprivation on the gut's cellular homeostatic process


NIH_SPENDING_CATS: Genetics

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: Project Narrative The proper development of vertebrates requires the deployment of morphogen signaling gradients and the ability of cells exposed to the morphogen to interpret different levels of signal. This proposal will identify mechanisms by which cells interpret the Bone Morphogenetic Protein (BMP) morphogen gradient, which when disrupted can lead to disorders such as cardiac defects, undifferentiated mesoderm, lack of germ cells, eye abnormalities, gastrointestinal diseases, Sjögren’s syndrome, and various cancers. By understanding how cells interpret levels of BMP signaling, my research will shed light on the mechanisms of BMP-derived diseases and congenital syndromes and provide important insight into how cells interpret other types of morphogen gradients.

PI_NAMEs: TELLO, COURTNEY  (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Affect;Animals;Auxins;Binding;Blood;Body System;Bone Morphogenetic Proteins;cell behavior;Cell Fate Control;cell motility;Cell Transplantation;cell type;Cells;Characteristics;combat;Communication;Complex;Confocal Microscopy;Critical Pathways;Defect;Development;Disease;Dose;Elements;Embryo;Environment;Exposure to;Eye Abnormalities;Fishes;Fluorescent Probes;Gastrointestinal Diseases;gastrulation;Gene Activation;Gene Expression;Gene Expression Profiling;Genes;Genetic;Genetic Transcription;Germ Cells;Germ Layers;Goals;heart defect;Heat-Shock Response;Human;Human Development;human disease;Immune system;Immune System Diseases;In Situ Hybridization;in vivo;insight;intercellular communication;Kidney;Knowledge;Lead;Length;Light;Link;Location;Malignant Neoplasms;Mesoderm;Mesoderm Cell;Methods;Microscopy;migration;Modeling;Modification;Molecular;morphogens;mosaic;mosaic analysis;notochord;novel;organ growth;Outcome;Output;overexpression;Paraxial Mesoderm;Pathway interactions;Pattern;Positioning Attribute;progenitor;Pronephric structure;Proteins;Regenerative Medicine;Reporter;Research;Resolution;Role;short bone;Signal Induction;Signal Pathway;Signal Transduction;Signaling Protein;Sjogren's Syndrome;Somites;Specific qualifier value;stem cells;Syndrome;synergism;System;Systems Development;Techniques;Temporal bone structure;Testing;Time;Tissues;transcription factor;transgene expression;Transgenic Organisms;Translating;Transplantation;Undifferentiated;Vent;Vertebrates;Work;Zebrafish;zebrafish development

PROJECT_TITLE: Interpreting Bone Morphogenetic Protein Gradients in Vertebrate Development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Human Genome;Lung;Orphan Drug;Precision Medicine;Pulmonary Fibrosis;Rare Diseases;Scleroderma

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PI_NAMEs: EICKELBERG, OLIVER  (contact)

PROJECT_TERMS: Affect;Area;Autoimmune;Autoimmune Responses;Automobile Driving;Biological Assay;Biological Markers;biological systems;Biology;biomarker identification;Blood;Blood Proteins;Blood Vessels;Cause of Death;Cell Communication;cell type;Cells;Chromatin;Chromium;clinical translation;Collagen;Connective Tissue Diseases;Coughing;Cues;Data;Deposition;diagnostic biomarker;Disease;Disease Progression;drug candidate;drug development;Drug Screening;Drug usage;Effector Cell;Epigenetic Process;epigenomics;Etiology;Exhibits;Extracellular Matrix;Fibroblasts;Fibrosis;Gene Expression;Genetic;Genome;Genomics;Goals;Histologic;Human;human tissue;idiopathic pulmonary fibrosis;Immune;improved;Inflammation;inhibitor;innovation;insight;Interstitial Lung Diseases;Longitudinal cohort;Lung;Lung Diseases;MADH3 gene;Maps;Mass Spectrum Analysis;Mediating;Mediator;Medical;Medicine;Mesenchymal;Methods;Midlife women;Minority;Modality;Modeling;Molecular;Monitor;Morbidity - disease rate;mortality;multiple omics;Mus;Myofibroblast;Network-based;neural network;new technology;new therapeutic target;nintedanib;Nonspecific Interstitial Pneumonia;novel;novel therapeutics;Nuclear;Organ;Pathogenesis;Pathway interactions;Patients;Pattern;Peripheral;peripheral blood;PIK3CG gene;predictive marker;Preparation;Prevalence;Prognostic Marker;Proteins;Proteome;Proteomics;pulmonary arterial hypertension;Pulmonary Fibrosis;pulmonary function decline;Raynaud Disease;Resolution;Scleroderma;Severity of illness;Skin;skin disorder;skin lesion;Slice;Structure of parenchyma of lung;Suspensions;Systemic Scleroderma;Testing;Therapeutic;therapeutic target;Tissues;tocilizumab;trait;transcriptome;transcriptomics;Transforming Growth Factor beta;translational study;United States Food and Drug Administration;Usual Interstitial Pneumonia;Vacuolar Protein Sorting;Vascular Diseases;vascular injury;Work;XCL1 gene

PROJECT_TITLE: From proteomics and genomics to therapeutics in systemic sclerosis interstitial lung disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Data Science;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

PI_NAMEs: RAJAN, KUMAR B. (contact)

PROJECT_TERMS: analytical method;Area;Biological Models;biological systems;Biomechanics;Biophysics;Characteristics;Clinical;clinical research site;clinically significant;Cognition;Cognitive;cognitive change;cohort;Collection;Complex;complex modeling;computer framework;computerized data processing;Country;Data;data access;Data Collection;data collection site;data de-identification;data harmonization;data integration;data management;Data Management Resources;data pipeline;Data Pooling;data portal;data repository;Data Security;Data Set;data sharing;data tools;Database Management Systems;database query;Databases;deep learning;Dementia;design;Development;Disease Progression;Enrollment;follow-up;Genetic;Goals;Image;Impaired cognition;Injury;innovation;Internet;Lesion;Machine Learning;Magnetic Resonance Imaging;Measures;member;Methods;Modeling;multimodality;neuroimaging;Outcome;Participant;participant enrollment;Performance;Plasma;Population;Population Heterogeneity;precision medicine;Process;programs;Protocols documentation;Qualifying;Quality Control;recruit;Reporting;repository;Research;Research Design;Research Personnel;Resources;Risk;Risk Factors;risk prediction;risk prediction model;Role;Secure;Site;Source;Standardization;Statistical Data Interpretation;statistics;Stratification;System;Testing;user-friendly;web app;web based interface;white matter;white matter injury;Work

PROJECT_TITLE: Statistics Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: OVERALL PROJECT NARRATIVE The tobacco industry has historically manipulated nicotine in its products to increase their appeal and potential for addiction for the widest possible audience, including young people and non-users. They are now doing this with newer products, like e-cigarettes and oral nicotine pouches. Our center will study how these manipulations affect young people and adults, with the goal of helping the FDA develop regulations that will make these products less appealing to young people, including non-users, but not older adult smokers and smokeless tobacco users who may benefit from their use.

PI_NAMEs: SHIELDS, PETER G.;WAGENER, THEODORE LEE (contact)

PROGRAM_OFFICER_NAME: PRUTZMAN, YVONNE M

PROJECT_TERMS: 3-Dimensional;absorption;abuse liability;addiction;addiction liability;Address;Adult;Advocate;Affect;Behavior;Biological Availability;career;Characteristics;Chemicals;Cigarette;Communication;Complementary therapies;Congresses;Data;Decision Making;demographics;Dermal;design;Dimensions;Drug Kinetics;Electronic cigarette;electronic cigarette use;electronic liquid;Environment;Evaluation;experience;Faculty;Flavoring;Fostering;Goals;Health;Human;improved;Industry;Intervention Studies;Isomerism;Laboratory Study;Marketing;Metabolism;Modeling;Monitor;Nicotine;nicotine craving;nicotine use;Nicotine Withdrawal;Observational Study;Occupational activity of managing finances;Ohio;Oral;Pattern;Persons;Population;population health;Postdoctoral Fellow;prevent;psychologic;Public Health;Regulation;Research Personnel;Research Project Grants;response;Rewards;Risk;risk perception;Sales;satisfaction;Science;Sensory;Signal Transduction;Smoke;Smokeless Tobacco;smokeless tobacco use;smokeless tobacco user;Smoker;student training;Testing;Time;Tobacco;Tobacco Industry;tobacco products;tobacco regulatory science;Tobacco Surveillance;Tobacco use;tobacco user;tool;Toxic effect;Toxicology;United States Food and Drug Administration;Universities;uptake;Withdrawal Symptom;Youth

PROJECT_TITLE: The Ohio State University Tobacco Center of Regulatory Science (OSU-TCORS)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-R(50)R]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities and Racial or Ethnic Minority Health Research;Pain Research;Physical Activity;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE The proposed research addresses a key public health problem, the need for feasible psychosocial interventions for people with chronic pain, that follow evidence-based guidelines and improve all aspects of physical function assessed by self- report, performance based and objective/ambulatory step count. Combining mind-body skills with walking aided by a Fitbit is feasible and has the potential to sustainably improve all aspects of physical and emotional function (whole person). This proposal follows IMMPACT and ICF criteria and directly addresses NCCIH's mission to apply rigorous scientific methods to the identification of complementary and integrative health interventions to improve management of chronic pain and the whole person.

PI_NAMEs: GREENBERG, JONATHAN ;VRANCEANU, ANA-MARIA  (contact)

PROGRAM_OFFICER_NAME: MURRAY, PETER DANIEL

PROJECT_TERMS: acceptability and feasibility;Accountability;actigraphy;Address;Adherence;Adult;Ambulatory Monitoring;Area;Benchmarking;Chronic;chronic musculoskeletal pain;chronic pain;chronic pain management;chronic pain patient;Classification;Clinical Trials;Competence;Complementary Health;cost;Data;disability;efficacy trial;emotional functioning;Enrollment;Ensure;ethnic minority;Ethnic Origin;evidence based guidelines;Expectancy;Feedback;fitbit;Focus Groups;follow-up;Funding;Future;Geography;Goals;Health;Impairment;implementation protocol;impression;improved;improved outcome;Individual;innovation;Integrative Medicine;International;Intervention;Interview;Measurement;Measures;meetings;Methodology;Methods;mind/body;Minority;Mission;Motivation;multi-site trial;multimodality;Musculoskeletal Pain;National Center for Complementary and Integrative Health;Non-Malignant;novel;Outcome;Pain;Pain Clinics;Pain Measurement;Participant;patient oriented;Patient Self-Report;Patients;Performance;Persons;Physical activity;Physical assessment;Physical Function;Population;preference;Preparation;Procedures;programs;Protocols documentation;Psychological reinforcement;psychosocial;Public Health;Publications;Questionnaires;Race;racial minority;Randomized;randomized, clinical trials;Recommendation;recruit;Relaxation;Research;Research Project Grants;resilience;response;routine care;Sampling;satisfaction;sedentary;Self Assessment;Signal Transduction;Single-Blind Study;Site;skills;success;Surveys;Testing;theories;Time;Training;Walking;whole health

PROJECT_TITLE: Improving multimodal physical function in adults with heterogeneous chronic pain; Multi-site feasibility RCT


NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Clinical Research;Lung;Pulmonary Hypertension;Rare Diseases;Scleroderma

PHR: In this proposal, we aim to define how cells in the blood vessels in the lung from persons who suffer from systemic sclerosis communicate with each other and promote the development of disease in those blood vessels. In doing so, we will embark on a first-in-human study to define a new imaging technique for better detection of blood vessel disease in lungs. If successful, our work could shape the principles of how blood vessel disease in the lungs develops, offering much needed and more effective ways to detect and treat this deadly condition in systemic sclerosis.

PI_NAMEs: CHAN, STEPHEN Y (contact)

PROJECT_TERMS: 18F-Glutamine;Automobile Driving;biobank;Bioenergetics;Biological Markers;Blood Platelets;Blood Vessels;cell type;Cells;Clinical;clinical diagnostics;Clinical Research;clinical translation;clinically relevant;Coculture Techniques;Collagen;Communication;Critical Pathways;Data;Deposition;Detection;Development;Diagnostic;Disease;early detection biomarkers;Enzymes;Fatty Acids;Feedback;Fibroblasts;first-in-human;Functional disorder;Gene Expression Profile;Glucose;Glutaminase;Glutamine;Human;human RNA sequencing;human study;Image;Imaging Techniques;innovation;Link;Lung;Maintenance;Measures;Mediating;Metabolism;Mitochondria;Molecular;multidisciplinary;novel;novel diagnostics;oxidation;Oxidative Phosphorylation;Pathogenicity;Patients;Persons;PET/CT scan;Positioning Attribute;Positron-Emission Tomography;pulmonary arterial hypertension;Pulmonary vessels;Right ventricular structure;Rodent;Role;Severities;Shapes;Signal Transduction;single-cell RNA sequencing;Skin;Symptoms;System;Systemic Scleroderma;Testing;Tracer;Transcription Coactivator;translational study;uptake;Vascular Proliferation;Vascular remodeling;Work;X-Ray Computed Tomography

PROJECT_TITLE: A platelet-fibroblast axis connecting bioenergetics and metabolism in SSc-pulmonary arterial hypertension


ORG_CITY: ANN ARBOR

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The proposed study seeks to define and overcome barriers to surgical video visit adoption. Improving avenues toward video adoption among surgeons will improve healthcare access, patient experience, and outcomes for millions of Americans undergoing surgical care, especially rural patients who travel long distances for care.

PI_NAMEs: ELLIMOOTTIL, CHANDY SKARIA (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Improving Video Visit Adoption by Surgeons

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: JIN, LEE-WAY  (contact)

PROJECT_TERMS: 3-Dimensional;Affect;Alzheimer's Disease;Alzheimer’s disease biomarker;Amyloid beta-42;Anatomy;apolipoprotein E-4;Bar Codes;Biological;Biological Markers;biomarker discovery;Blood;Blood specimen;Brain Injuries;Categories;Clinic;Clinical;Clinical Data;clinical research site;clinically significant;Cognitive;Collaborations;Collection;Communities;comorbidity;cost efficient;Data;data integrity;Data Set;data sharing;Databases;Dementia;Deposition;Derivation procedure;DNA;endothelial dysfunction;Ensure;Equipment and supply inventories;exome sequencing;experience;Freezing;Future;Genetic;Genetic Predisposition to Disease;genome-wide;Genotype;Glial Fibrillary Acidic Protein;Goals;IL18 gene;Impaired cognition;Individual;Inflammation;Inflammatory;Infrastructure;interest;Leadership;Lesion;Light;Liquid substance;Location;Longitudinal Studies;Machine Learning;Magnetic Resonance Imaging;Measures;Mission;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;neurofilament;neuroimaging;NOTCH3 gene;novel marker;Pathology;Pathway interactions;Phenotype;Plasma;polygenic risk score;Population;Population Heterogeneity;precision medicine;Procedures;Process;programs;Protocols documentation;Qualifying;Quality Control;Recommendation;recruit;Regulation;repository;Reproducibility of Results;Research;Research Personnel;Research Support;Resource Sharing;Resources;Retrieval;Risk;risk prediction model;Role;Sampling;Secure;Services;Shipping;Site;Specimen;Standardization;standardize measure;synergism;System;tau Proteins;Therapeutic;Time;Validation;Variant;vascular risk factor;white matter;White Matter Hyperintensity;white matter injury;Work

PROJECT_TITLE: Repository Core


ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: PROJECT NARRATIVE As a public health response to the COVID-19 pandemic, telehealth was widely implemented, including in pediatric primary care where it is highly likely to continue being a frequent mode of care after the pandemic. However, telehealth changes the communication and structure of healthcare interactions which may impact shared decision making and health outcomes for children with chronic conditions. Having an in-depth understanding of the impact of telehealth on shared decision making and health outcomes will position us to develop targeted interventions aimed at ensuring the use of telehealth does not increase health disparities, particularly for the large number of inner-city and minority children with chronic conditions.

PI_NAMEs: LIPSTEIN, ELLEN A (contact)

PROGRAM_OFFICER_NAME: EDEN, AIMEE

PROJECT_TITLE: Comparing Family Decision Making Engagement in Telehealth versus In-person Primary Care for Children with Chronic Conditions

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: Groton

ORG_NAME: VIRTUS THERAPEUTICS CORPORATION

ORG_STATE: CT

PHR: NARRATIVE Pantothenate kinase-associated neurodegeneration (PKAN) is a rare genetic disorder that causes progressive extrapyramidal dysfunction and dementia and characterized by iron deposition in the brain. The disease is caused by autosomal recessive mutations in the PANK2 gene, which encodes the enzyme pantothenate kinase, responsible for the metabolism of vitamin B5 (pantothenate). Herein, we propose biochemical, cell biological and mouse studies to evaluate the efficacy and safety of a novel class of molecules for the treatment of the disease.

PI_NAMEs: REGAN, JESSICA  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, FLOY ANNETTE

PROJECT_TERMS: Anabolism;analog;Animals;autosome;Binding;Biochemical;Biological;Biological Assay;Brain;candidate identification;Cells;cellular imaging;Cessation of life;Chemicals;Clinical;clinical candidate;clinical development;Coenzyme A;cofactor;Collaborations;Cytoplasm;Data;Defect;Dementia;Deposition;Development;Disease;Disease Progression;Drug Kinetics;efficacy evaluation;emerging adult;enzyme activity;Enzymes;Family;Functional disorder;Future;Generations;Genes;Goals;high throughput screening;Homeostasis;Human;Human Activities;Human Cell Line;Human Genome;Immobilization;improved;In Vitro;in vitro activity;in vivo;in vivo evaluation;Iron;Kinetics;Knowledge;Lead;lead candidate;lead optimization;Libraries;Life;Metabolic;Metabolic Pathway;Metabolism;Mitochondria;Mitochondrial Diseases;mitochondrial metabolism;Monitor;mouse model;Mus;Mutate;Mutation;Neurodegenerative Disorders;Normal Cell;novel;novel marker;Organ;Pantothenate kinase;Pantothenate kinase-associated neurodegeneration;Pantothenic Acid;Patient-Focused Outcomes;Patients;Permeability;Pharmaceutical Chemistry;Phase;Phenotype;Phosphorylation;Physiological;Plasma;Production;Property;Protein Isoforms;Protein Kinase;rare genetic disorder;repaired;Research;research clinical testing;response;Safety;screening;Small Business Innovation Research Grant;small molecule;small molecule libraries;Solubility;success;symptom management;Testing;Therapeutic;Therapeutic Index;Tissues;Toxic effect;treatment strategy;Triazoles;vitamin metabolism

PROJECT_TITLE: PANK Activators for the treatment of pantothenate kinase-associated neurodegeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-P(11)B]


PI_NAMEs: WAGENER, THEODORE LEE (contact)

PROJECT_TERMS: 21 year old;abuse liability;Acclimatization;addiction;Address;Adult;Air;animal data;base;Behavior;Behavioral;blind;Blood specimen;cancer biomarkers;cancer risk;Cardiovascular Diseases;cardiovascular endothelium;Cardiovascular system;Cell Culture Techniques;Cell Cycle;Cell Proliferation;Chemicals;Cigarette;Cigarette Smoker;combustible cigarette;Cotinine;Cross-Over Trials;Crossover Design;cytotoxicity;Data;design;Dimensions;Double-Blind Method;Drug Kinetics;e-cigarette aerosols;Electronic cigarette;electronic cigarette use;electronic cigarette user;electronic liquid;Endothelial Cells;Epithelium;Exposure to;Fostering;Health;Hour;Human;human data;hydroxycotinine;In Vitro;Industry;Inhalation;innovation;Isomerism;Liquid substance;Malignant neoplasm of lung;Malignant Neoplasms;Manufacturer;Marketing;Measures;Metabolic;metabolic profile;metabolic rate;Metabolism;Methods;Modeling;Modernization;Nicotine;nicotine use;Ohio;older adult;Outcome;Outcome Assessment;Participant;Pattern;Persons;pharmacologic;Population;Public Health;Randomized;Reactive Oxygen Species;Regulation;Research;respiratory;Respiratory Disease;Risk;Route;Salts;satisfaction;Science;senescence;Smoker;Smoking;Smoking History;stem;Stereoisomer;Surrogate Markers;Testing;Tobacco;tobacco flavor;Tobacco Industry;tobacco products;tobacco user;Toxic effect;toxicant;Toxicology;transcriptome sequencing;Universities;uptake;vaping;Visit;young adult;Youth

PROJECT_TITLE: Project 1: Manipulating E-cigarette Nicotine to Promote Public Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-R]