ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE The research program of this center focuses on the impact of substance use on risk for, development, and progression of chronic diseases. Better understanding of this relationship is expected to benefit individuals with substance use disorders and/or chronic diseases. The center’s projects are led by early career scientists to prepare them for advanced research careers in service of public health.

PI_NAMEs: MONTI, PETER M. (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: addiction;Affect;Alcohol consumption;anxiety symptoms;Applications Grants;Area;Award;biobehavior;biopsychosocial;Businesses;Cannabis;career;career development;Centers of Research Excellence;Child;Chronic Disease;Clinical;clinically relevant;cohort;commune;Communities;Community Health;cost effectiveness;Development;digital;Disease;disorder risk;Enrollment;Environment;ethnic health disparity;Evaluation;experience;Faculty;faculty mentor;Fostering;Funding;Goals;Health;health disparity;high risk;Human Resources;Human Subject Research;Individual;Infrastructure;innovation;insight;Interdisciplinary Study;interest;intergenerational;Intervention;Knowledge;Laboratories;Lead;Learning;life course persistent;Life Cycle Stages;Link;longitudinal, prospective study;Manuscripts;marijuana use;Measures;member;Mental Health;Mentors;Mentorship;mid-career faculty;mood symptom;multidisciplinary;Needles;next generation;Nicotine;novel;Obesity;organizational structure;Outcome;Peer Review;people of color;perinatal period;Persons;Phase;Physiological;Pilot Projects;pregnant;Prevention;Productivity;programs;public health relevance;Publications;Publishing;racial health disparity;recruit;Reproducibility;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Rhode Island;Risk;Risk Factors;Science;Scientist;Services;shared database;Smoke;Smoking;social health determinants;socioeconomics;stress symptom;substance use;Substance Use Disorder;success;Technology;Translational Research;United States National Institutes of Health;United States Public Health Service;Universities;Weight;Work

PROJECT_TITLE: Center for Addiction and Disease Risk Exacerbation


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: RELEVANCE (PARENT GRANT) The ultimate goal of this proposal is to uncover how pre-mRNA splicing and trafficking through nuclear speckles is controlled by the kinase TAO2, and why TAO2 is required for successful Influenza virus (IAV) replication. This work will have implications not only for viral infections but also for general mechanisms of RNA splicing and nuclear speckle function.

PI_NAMEs: COBB, MELANIE H.;FONTOURA, BEATRIZ MA;LYNCH, KRISTEN W (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Alternative Splicing;Biochemistry;Cells;Chemicals;Data;genetic manipulation;Genetic Transcription;Goals;Human;Impairment;influenza infection;influenzavirus;Integration Host Factors;Mass Spectrum Analysis;Messenger RNA;Microscopy;mRNA Precursor;Nuclear;Nuclear Proteins;parent grant;Phosphorylation;Phosphotransferases;Protein Kinase;Proteins;Regulation;RNA;RNA Splicing;RNA-Binding Proteins;Role;trafficking;viral RNA;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Kinase Regulation of Nuclear Speckle Function and Splicing during Influenza Virus Infection


NIH_SPENDING_CATS: Biotechnology;Immunization;Infectious Diseases;Prevention;Sexually Transmitted Infections;Vaccine Related

ORG_CITY: BOSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: PROJECT NARRATIVE After an initial infection with many pathogens, the immune system provides protection against re-infection with the same pathogen. However, infection of the human female reproductive tract with Chlamydia trachomatis provides limited protection against reinfection, and reoccurring infections can cause permanent damage and infertility. The goal of this proposal is to 1) determine why the cells of the immune system fail to provide protection against C. trachomatis, and 2) reprogram these faulty cells using new vaccine approaches to provide protection.

PI_NAMEs: STARNBACH, MICHAEL N (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Adaptive Immune System;Adjuvant;Binding;Biological Response Modifiers;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cellular Immunity;Cellular Immunology;Chlamydia;Chlamydia trachomatis;Cytotoxic T-Lymphocytes;Encapsulated;Failure;female reproductive tract;Goals;Health Care Costs;Human;human female;Immune system;Immunity;Impairment;Infection;Infertility;Mediating;Memory;Methods;Morbidity - disease rate;Mus;nanoparticle;novel vaccines;Organism;pathogen;Persons;prevent;Primary Infection;programs;Reagent;reproductive tract;response;T memory cell;T-Lymphocyte;Testing;vaccine development;vaccine formulation;vaccine strategy;Vaccines;Work

PROJECT_TITLE: Cytotoxic T Cell Mediated Immunity to Chlamydia


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: WASHINGTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative To widen the HIV research career pathway for early-stage scholars from diverse groups, the National Institutes of Health supported the development of the Centers for AIDS Research (CFAR) Diversity, Equity, and Inclusion Pathway Initiative (CDEIPI). The local CFAR Pathway program, now in its third year under supplemental funding, was developed to enhance the current aims of the Developmental Core by creating a pathway for high school and undergraduate students to engage in HIV research. The pre-professional workshops, didactic seminar series and proposed one-credit course focusing on HIV and Health Disparities align with our aim to provide educational and networking activities that promote multidisciplinary, cross- institutional, and community collaborative HIV research.

PI_NAMEs: GREENBERG, ALAN EDWARD (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adopted;after-school program;AIDS prevention;Award;Biomedical Research;career;Career Choice;cohort;Communities;community collaboration;Degree program;Development;District of Columbia;driving force;Education;Educational process of instructing;Educational workshop;elementary school;Enrollment;Epidemic;equity, diversity, and inclusion;Ethnic Population;Event;experience;Exposure to;Faculty;Fostering;Funding;Gender;Generations;Goals;graduate student;Grant;Health;health disparity;high school;High School Student;HIV;HIV disparities;improved;innovation;Institution;interest;Lead;Leadership;meetings;member;Mentors;Mentorship;Mission;multidisciplinary;next generation;Outcome;parent grant;Parents;Pathway interactions;peer coaching;Persons;programs;Quality of life;racial population;Research;Research Personnel;Research Support;Research Training;Science;Scientist;Self Efficacy;Series;skills;Students;undergraduate student;Underrepresented Populations;United States National Institutes of Health;Universities;Washington;Work

PROJECT_TITLE: District of Columbia Center for AIDS Research (Dev Core)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 SA-A (S1)]


NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS;Infectious Diseases

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adopted;Affect;Attention;Award;Behavioral;Behavioral Research;Biomedical Research;career;Clinical;cohort;Communities;Community Developments;community partners;Complement;Data;Degree program;design;Development;District of Columbia;Environment;equity, diversity, and inclusion;Ethnic Population;experience;Exposure to;Faculty;Financial Support;Fostering;Future;Gender;Goals;graduate student;Grant;Health;high school;High School Student;higher education;HIV;Infrastructure;innovation;Institution;interest;Intervention;Lead;Leadership;leadership development;member;Mentors;Mentorship;Minority Groups;multidisciplinary;National Institute of Neurological Disorders and Stroke;outreach;Pathway interactions;peer coaching;Phase;Population Sciences;Postdoctoral Fellow;programs;racial minority population;racial population;recruit;Research;Research Personnel;Research Training;Role;Science;Scientist;Self Efficacy;skills;social;Strategic Planning;student mentoring;student retention;Students;success;Training;undergraduate student;Underrepresented Minority;Underrepresented Populations;Universities;volunteer

PROJECT_TITLE: DC CFAR Developmental Core


ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE A major issue related to successful transplantation in patients is the shortage of human organs available, in addition to the high levels of immunosuppression necessary to prevent xenograft rejection, without guarantee of success. This need to establish pig-specific tolerance in humans leads to this proposal to investigate the direct and indirect pig-specific human regulatory T cell response. We will identify and characterize the directly pig- reactive human Treg repertoire using healthy control human PBMCs and pig PBMCs, in addition to characterizing the indirectly pig-reactive human Treg response, which will involve the use of human APCs to present pig antigen with healthy control PBMCs.

PI_NAMEs: SACHS, DAVID H;SYKES, MEGAN  (contact)

PROGRAM_OFFICER_NAME: NABAVI, NASRIN N

PROJECT_TERMS: Address;Antigens;B-Lymphocytes;Chimerism;Defect;Development;Epithelium;Family suidae;Genetic Polymorphism;Graft Rejection;Human;Hybrids;immune function;Immunosuppression;improved;Investigation;Methods;Modeling;Mus;Organ;Organ Transplantation;Papio;parent grant;Parents;Patients;Peripheral Blood Mononuclear Cell;prevent;Regulatory T-Lymphocyte;response;Role;Specificity;success;T cell response;T-Cell Development;T-Lymphocyte;Thymus Gland;thymus transplantation;Transplantation;Xenograft procedure

PROJECT_TITLE: A Tolerance Approach to Xenotransplantation


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Mental Health;Mental Illness;Pediatric;Prevention;Sleep Research;Suicide;Suicide Prevention

ORG_CITY: PISCATAWAY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Rates of adolescent suicide have increased in recent years, alongside rates of social media use, which has raised public concern about the relationship between social media and suicidal ideation in adolescents. The purpose of this application is to examine the temporal and unique relationships between different aspects of social media use and suicidal ideation in adolescents, and evaluate sleep disruption as a potential mechanism. Results of this study have the potential to inform scalable and equitable suicide prevention programs and evidence-based social media use guidelines to improve adolescent mental health.

PI_NAMEs: HAMILTON, JESSICA LEIGH (contact)

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: actigraphy;Adolescent;adolescent mental health;adolescent suicide;Affect;Cause of Death;Cellular Phone;Clinical;Collection;Communities;Consultations;Coupling;critical period;Data Analyses;design;Development;diaries;Ecological momentary assessment;emotion regulation;Emotional;Ensure;Equity;ethnic minority;Event;evidence base;experience;Feeling suicidal;Focus Groups;Frequencies;Future;gender minority;Guidelines;high risk;high-risk adolescents;Hospitalization;Hospitals;Impairment;improved;Infrastructure;innovation;inpatient psychiatric treatment;Intervention;Link;Maps;media use;meetings;Methodology;Methods;Minority;Modeling;Monitor;Nature;Parents;Pathway interactions;Patient Self-Report;Pattern;Persons;Policies;Prevention;Prevention program;Process;prospective;psychiatric inpatient;Public Health;racial minority;Recommendation;recruit;Research;response;Risk;Risk Factors;Role;Sampling;Self-control as a personality trait;sexual minority;Site;Sleep;Sleep Deprivation;Sleep disturbances;social;social influence;Social Interaction;social media;Social support;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide prevention;suicide rate;theories;Time;United States;Youth

PROJECT_TITLE: Bidirectional relationships between positive and negative social media use and suicidal ideation in high-risk adolescents

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-R (05)]


PHR: PROJECT NARRATIVE This proposal would revise the NIH-funded District of Columbia AIDS Research (DC CFAR) to include the CFAR Pathway Program Coordinating Center (CPPCC) which would coordinate and support HIV research training and mentoring pathway programs for high school, undergraduate, graduate, and postdoctoral students in the national network of CFARs. The CPPCC would expand upon the work of the Coordinating Center for the CFAR Diversity, Equity and Inclusion Pathway Initiative (CDEIPI) in which CFARs developed HIV research training programs for students with an emphasis on persons from groups underrepresented in the HIV-related scientific workforce. The overall goal of CFAR pathway programs is to contribute to the development of the next diverse generation of HIV investigators who can contribute to ending the HIV epidemic in the United States.

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Amendment;Area;Award;Behavioral Research;Behavioral Sciences;Biomedical Research;career;Clinical;Clinical Research;Collaborations;Communication;Communities;COVID-19;Development;District of Columbia;doctoral student;Education;Elements;Epidemic;equity, diversity, and inclusion;ethnic minority;Evaluation;experience;Fostering;Funding;Funding Opportunities;Generations;Goals;Government;Grant;high school program;HIV;Individual;Infrastructure;innovation;Institution;interdisciplinary approach;Language;Leadership;Left;Medicine;Mentors;Mission;Monitor;Monkeypox;multidisciplinary;next generation;Outcome;Participant;Pathway interactions;Persons;phrases;Postdoctoral Fellow;Prevention;programs;racial minority;recruit;Research;Research Personnel;Research Support;Research Training;Scholars Program;Science;Scientist;Social Sciences;Students;Training;training opportunity;Training Programs;undergraduate student;Underrepresented Minority;Underrepresented Populations;United States;United States National Institutes of Health;Washington;Woman;Work

PROJECT_TITLE: District of Columbia Center for AIDS Research (Admin Core)


PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Behavioral Sciences;Characteristics;Collaborations;Communication;community partners;Consensus;Development;District of Columbia;Evaluation;experience;Feedback;Funding;Goals;Government;Individual;innovation;Institution;Leadership;Maintenance;meetings;Mentors;Monitor;multidisciplinary;Newsletter;Outcome Measure;Pathway interactions;Process Measure;Program Development;Program Evaluation;programs;Publications;Research;Research Personnel;Resources;Schedule;Science;Site;social science research;success;United States National Institutes of Health;Universities;web site;working group

PROJECT_TITLE: DC CFAR Administrative Core


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Autoimmune Disease;Eye Disease and Disorders of Vision

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE – NO CHANGES FROM PARENT GRANT Autoimmune-mediated eye disease is a pathological hallmark of multiple systemic autoimmune diseases. With a severe lack in efficacious treatment options that is driven by a combination of inadequate early detection strategies and a poor understanding of disease mechanisms, patients suffer life-long morbidity. Using innovative new technologies, we seek to define the mechanisms driving dry eye disease development at the single cell level, with the goal of discovering new targets for therapeutic intervention.

PI_NAMEs: KNOX, SARAH MONICA (contact);MCNAMARA, NANCY A

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Anterior;aqueous;Autoimmune;Automobile Driving;Awareness;Cell Lineage;Cell Nucleus;cell type;Cells;Chronic;Clinical;Confocal Microscopy;Cornea;Corneal Diseases;corneal epithelium;curative treatments;Data;Development;Diagnostic;Disease;Disease Progression;driving force;Dry Eye Syndromes;Early Diagnosis;Early Intervention;efficacious treatment;Endothelial Cells;Epithelial Cells;Epithelium;Exocrine Glands;Eye;Eye diseases;eye dryness;Generations;Genetic;Genetic Variation;Goals;Heterogeneity;Homeostasis;Human;Hyperplasia;Immune;Immunofluorescence Immunologic;Impairment;Inbred BALB C Mice;Infiltration;Inflammation;Inflammatory;innovation;insight;Lacrimal gland structure;limbal;Lupus;Maps;Mediating;microbial;Modeling;Molecular;Morbidity - disease rate;mouse model;Mus;nerve supply;Neural Crest;new technology;new therapeutic target;novel;ocular surface;Organ;Outcome;Outcome Study;parent grant;Pathologic;Patients;prevent;Process;repaired;Rheumatoid Arthritis;Signal Transduction;single nucleus RNA-sequencing;Sjogren's Syndrome;stem cell population;stem cells;Stromal Cells;stromal progenitor;systemic autoimmune disease;Therapeutic;therapeutic development;Therapeutic Intervention;Time;Tissues;transcriptome sequencing;treatment strategy;ultra high resolution

PROJECT_TITLE: Defining mechanisms driving dry eye disease progression

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: KINGSTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF RHODE ISLAND

PHR: Project Narrative This project will provide novel insights for HIV interventions among marginalized populations that use illicit substances by studying spillover in HIV risk networks with potential for applications to other infectious diseases and intervention research methodology. Despite advances in HIV treatment and prevention, young black men who have sex with men (BMSM) experience a disproportionate burden of HIV infection and critical work remains to evaluate the potential for benefit beyond the treated individual (spillover) in these interconnected HIV risk networks among BMSM. We propose to evaluate spillover of HIV interventions in marginalized populations using both secondary data analyses of existing data and simulation approaches requiring the development of novel study design, inferential, and modeling methods.

PI_NAMEs: BUCHANAN, ASHLEY LYNN (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Address;Affect;AIDS prevention;black men who have sex with men;Calibration;Chicago;Cohort Studies;Communicable Diseases;Communities;Complex;Computer Models;Contact Tracing;Data;Data Analyses;Data Set;Dependence;design;Development;Disease;Drug usage;Environment;Epidemic;Evaluation;experience;Future;Goals;Health;Health Resources;HIV;HIV Infections;HIV risk;Illinois;improved;Individual;innovation;insight;Intervention;Intervention Studies;Leadership;marginalized population;Measures;men who have sex with men;Methodology;Methods;Modeling;Neighborhoods;network models;Network-based;novel;novel strategies;Outcome;Participant;peer;Policies;Population;Population Study;Populations at Risk;Positioning Attribute;power analysis;pre-exposure prophylaxis;prevent;Prevention;programs;Public Health;racial disparity;Research;Research Design;Research Methodology;Research Personnel;Resources;Rhode Island;Risk;Risk Behaviors;Role;Sample Size;Scientist;simulation;Social Environment;Social Network;substance use;System;tool;transmission process;treatment as prevention;Universities;uptake;Vaccines;Work;Writing

PROJECT_TITLE: Network-based study design, statistical, and modeling solutions for HIV among populations that use illicit substances: Informing interventions and policy in real-world settings using existing data

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 LXF-E (A1)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Decision making based on reinforcement learning (RL) is a fundamental process of animal behavior that is impaired in psychiatric disorders such as schizophrenia and ADHD. We propose to study neural circuit mechanisms mediating RL-based decision making using cutting-edge circuit dissection tools in mice.

PI_NAMEs: KOMIYAMA, TAKAKI  (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TERMS: Animal Behavior;Architecture;Area;Artificial Intelligence;Attention deficit hyperactivity disorder;Behavioral;Brain;Calcium;Cognition Disorders;Cognitive;Complex;Decision Making;deep reinforcement learning;Development;Diagnosis;Dissection;Dopamine;flexibility;Impairment;insight;Learning;Learning Disorders;learning network;learning strategy;Mediating;Mental disorders;Modeling;mouse genetics;Mus;neural circuit;neuroimaging;neuromechanism;Neurosciences;novel;optogenetics;Performance;Play;Population;Process;Psychological reinforcement;Psychology;Role;Schizophrenia;Signal Transduction;Synaptic plasticity;Technology;tool;Training;two-photon;Work

PROJECT_TITLE: Cortical plasticity during reinforcement learning - Diversity Supplement

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: DP

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: This project aims to examine the effect of 3 durations of moderate to vigorous intensity physical activity (45 min/week, 90 min/week, and 150 min/week) on arthritis-attributable outcomes in adults with arthritis as well was explore whether these doses have differential effects on momentary symptoms. These results will provide insight on whether engaging in activity below physical activity guidelines has beneficial effects on arthritis- related outcomes.

PI_NAMEs: PELLEGRINI, CHRISTINE ANN (contact);WILCOX, SARA

PROGRAM_OFFICER_NAME: DARLING, NATALIE

PROJECT_TITLE: Examination of the Dose Response Relationship Between Physical Activity and Arthritis-Attributable Outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZDP1 FMC (10)]


ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Modified Public Health Relevance Section  The Implementation Science Coordination Initiative seeks to maximize the value of implementation science (IS) in the national Ending the HIV Epidemic plan by: (1) supporting high-quality IS in funded projects by providing technical assistance from experts on IS concepts and methods, and (2) creating opportunities for local knowledge to become generalizable knowledge by encouraging the use of shared frameworks and measures, synthesizing data across projects, and promoting collaboration. In collaboration with the Regional Consultation Hubs (RCH), ISCI will expand its infrastructure as a national resource to guide the field of HIV IS.

PI_NAMEs: D'AQUILA, RICHARD ;MUSTANSKI, BRIAN  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;African American;age acceleration;aging mechanism;aging related;aging related disease;AIDS prevention;Aquila;Behavioral;behavioral and social science;Behavioral Sciences;Biological Assay;Biological Markers;Black race;career;Career Choice;Caring;Cells;Chicago;Clinical;clinical phenotype;Clinical Sciences;cohort;Collaborations;Communication;Communities;community engagement;community organizations;community partners;comorbidity;Consultations;Data Analytics;Data Science;design;Development;Diagnostic;Discipline;Disease remission;Doctor of Philosophy;empowerment;Engineering;Epidemic;equity, diversity, and inclusion;Foundations;Funding;gender minority group;Growth;Health;health data;health organization;Health Professional;Health Services;Heart;HIV;HIV/AIDS;Illinois;Image;Immunity;implementation science;improved;Indigenous;Informatics;Infrastructure;innovation;Institution;interdisciplinary collaboration;Intervention;Leadership;Market Research;Mentored Clinical Scientist Development Program;Mentors;Minority;Minority Graduate Student;minority health;minority health disparity;Minority Health Research;Modeling;multidisciplinary;National Heart, Lung, and Blood Institute;Outcome;Partnership Practice;people of color;Persons;Populations at Risk;Postdoctoral Fellow;pre-exposure prophylaxis;Prevention;Productivity;programs;Public Health;recruit;Reporting;Research;Research Personnel;Research Priority;Research Training;Resources;Risk;Scholars Program;Science;Scientist;Services;Sexual and Gender Minorities;skills training;Sleep;social;Social Sciences;Specimen;Speed;Strategic Planning;synergism;Systems Biology;Technology;Testing;Training;training opportunity;transgender women;Translational Research;Underrepresented Minority;United States National Institutes of Health;Universities;Viral;Viral Pathogenesis;Viremia;virology;Vulnerable Populations;Work;working group;young men who have sex with men

PROJECT_TITLE: Third Coast Center for AIDS Research


NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: DACUS, JAGADISA-DEVASRI  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adolescent;Affect;AIDS prevention;Behavioral;Biomedical Research;Black race;Black, Indigenous, People of Color;Businesses;career;Career Choice;career development;Collaborations;Communities;community organizations;Complement;Creativeness;Data Set;Development;Disabled Persons;Discrimination;Disparity;empowerment;Epidemic;equity, diversity, and inclusion;Evaluation;falls;Future;gender diverse;gender minority community;gender minority group;gender minority health;gender minority health research;gender nonconforming;General Population;Goals;Guidelines;Health;health disparity;Health Services;high risk;Historically Black Colleges and Universities;HIV;HIV/AIDS;Home;improved;Individual;Infrastructure;insight;Institution;Intervention Studies;Latinx;Lesbian Gay Bisexual Transgender Queer;Lived experience;Mentors;Mentorship;Minority;Minority Graduate Student;minority health;minority health disparity;Minority Health Research;Minority Status;Minority-Serving Institution;multidisciplinary;National Institute on Minority Health and Health Disparities;next generation;nonbinary;Participant;Pathway interactions;Personal Satisfaction;Persons;Policy Maker;Population;Postdoctoral Fellow;Prevention Research;programs;Publishing;recruit;Research;Research Institute;Research Personnel;Research Priority;Research Training;Resources;Scholars Program;Science;Scientist;service providers;Sexual and Gender Minorities;sexual minority men;Social Sciences;social stigma;Structural Racism;symposium;Training;training opportunity;transgender;Translational Research;Underrepresented Minority;Underrepresented Populations;underserved community;Underserved Population;United States National Institutes of Health;Universities;Woman;Youth

PROJECT_TITLE: Partnering and Programming for a BIPOC SGM Pathway to HIV Research


NIH_SPENDING_CATS: Complementary and Integrative Health;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Nutrition;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: AMHERST

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: PROJECT NARRATIVE We will test the hypothesis that VLCPUFAs can alter cholesterol metabolism and oxidation in RPE cells, and thereby affect RPE cell function. Since the RPE is a key player in regulating retinal cholesterol homeostasis, we anticipate that VLCPUFAs will affect that process, in a manner that would be protective against retinal degeneration in vivo.

PI_NAMEs: FLIESLER, STEVEN J. (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Affect;Antioxidants;Applications Grants;Autophagocytosis;Award;bench to bedside;Biological;Biological Models;cardiometabolic risk;Cattle;Cell Membrane Structures;Cell Physiology;cell type;Cells;Cholesterol;Cholesterol Homeostasis;comparative;Defect;Development;Digestion;Disease;Equilibrium;Eukaryotic Cell;Family;Fish Oils;Funding;Genetic Diseases;Goals;Human;human induced pluripotent stem cells;improved;In Vitro;in vivo;induced pluripotent stem cell;Inflammatory;Inherited;insight;Intervention;Investigation;Lipids;Lipoproteins;Liver;lysosome membrane;Membrane;Methods;Molecular;Neural Retina;Neuroglia;Niacinamide;novel;Outcome;outcome prediction;Outcome Study;oxidation;oxidative damage;Oxidative Stress;parent project;Pathologic;Patients;Phagocytes;Phagocytosis;Polyunsaturated Fatty Acids;Process;Retina;Retinal Degeneration;Retinal Diseases;retinal neuron;retinal rods;Risk Factors;Rod Outer Segments;Signal Transduction;Sirolimus;Sterols;Structure of retinal pigment epithelium;Testing;Therapeutic Intervention;Tissues;TNF gene;trafficking;United States National Institutes of Health;uptake;Vascular blood supply;Vision

PROJECT_TITLE: Cholesterol homeostasis in the vertebrate retina


ADMINISTERING_IC: FD

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: ITHACA

ORG_DEPT: NUTRITION

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative The Produce Safety Alliance (PSA) serves to help ensure the safety of fresh fruits and vegetables by providing training, educational materials, technical assistance, and facilitating discussion among stakeholders, including growers, packers, shippers, regulators, educators, and others in the produce industry. Diverse produce commodities continue to be implicated in foodborne outbreaks, highlighting the importance of effective identification of risks and implementation of practices to reduce risks, such as Good Agricultural Practices (GAPs), those outlined in the Food Safety Modernization Act (FSMA) Produce Safety Rule (PSR), and third- party audits. Supporting the produce industry through effective education and training programs helps to provide access to safe, wholesome fruits and vegetables, to prevent economic losses associated with recalls and foodborne illnesses, and to bolster farm economic viability through market maintenance and expansion.

PI_NAMEs: BIHN, ELIZABETH A (contact)

PROGRAM_OFFICER_NAME: DUCHARME, DIANE

PROJECT_TITLE: Continuation of the Produce Safety Alliance to Enhance Understanding and Compliance with the FSMA Produce Safety Rule

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CFSN-T (04)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: MILLER, GARY W (contact)

PROGRAM_OFFICER_NAME: ROTUNNO, MELISSA

PROJECT_TERMS: Adopted;Africa;African;African ancestry;Air Pollution;anti-cancer research;Automation;biobank;Biological;black patient;Blood specimen;Budgets;cancer health disparity;cancer risk;Chromatography;cloud based;cohort;Collaborations;Communities;Complex;computer framework;Computer software;Data;Data Element;data repository;Databases;early onset;Environment;environmental chemical;Environmental Exposure;Epigenetic Process;Equity;Gas Chromatography;Genetic;genome sequencing;Genomics;Geography;Germ Lines;Green space;Immunoassay;Immunologic Factors;Immunologics;improved;Incidence;industry partner;Inequality;Link;Liquid Chromatography;Lived experience;Machine Learning;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;marginalized population;Mass Spectrum Analysis;Measurement;Measures;member;Methods;Molecular;novel;novel strategies;outcome disparities;Participant;Pathway interactions;Patient advocacy;Patient Self-Report;Patients;Persons;Phase;Plasma;Policies;Population;precision oncology;Predisposition;Preparation;Primary Neoplasm;Procedures;profiles in patients;racism;Research;Research Personnel;Resolution;Resources;response;Sampling;Science;Scientist;Site;small molecule;social;social determinants;Surveys;sustainability framework;Technology;Training;transcriptomics;treatment and outcome;trial design;tumor;Tumor Tissue;Underserved Population;virtual;wasting;whole genome;Work

PROJECT_TITLE: SAMBAI-Columbia


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE The University of Chicago (UChicago) Center for Healthy Aging Behaviors and Longitudinal InvestigationS (CHABLIS) will promote research in the demography and economics of aging and assist junior scholars as they engage in this research domain. We draw on projects such as NSHAP and CCP to develop opportunities for scholars, both junior and senior, to collaborate on science and survey methods in a longitudinal context.

PI_NAMEs: MELTZER, DAVID O (contact);WAITE, LINDA J

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Aging;aging population;Area;Attention;Behavior;career development;Centers for Population Health;Chicago;Collaborations;Comprehensive Health Care;Data;Data Collection;Demographic Factors;Demography;design;Discipline;early-career faculty;Economic Factors;Economics;Evaluation;Future;Goals;Health;healthy aging;Individual;Influentials;Infrastructure;infrastructure development;innovation;Intervention Studies;Investigation;Joints;Lead;Life;Life Cycle Stages;Measurement;Medical;Medicine;member;Mentors;Methodology;Methods;next generation;Observational Study;older adult;Outcome;Persons;Physicians;Pilot Projects;Process;Productivity;Program Development;programs;Research;research and development;Research Support;Resources;Schools;Science;social;Social Sciences;Sociology;Survey Methodology;synergism;Universities

PROJECT_TITLE: Center for Healthy Aging Behaviors & Longitudinal InvestigationS (CHABLIS)


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Contraception/Reproduction;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Infertility;Rare Diseases

ORG_CITY: ROCHESTER

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Polymers that display many copies of important sugars are being developed to specifically treat cholera disease and to diagnose sperm dysfunction. Understanding how these polymers work will provide better strategies to combat bacterial disease, and to understand causes of infertility. Monomers for use in alternating ring-opening copolymerization methods will be developed to create new materials.

PI_NAMEs: SAMPSON, NICOLE S (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TITLE: Polymer Approaches to Receptor Activation and Inhibition


ORG_CITY: PORTLAND

ORG_NAME: MAINEHEALTH

ORG_STATE: ME

PHR: The dramatic underrepresentation of Non-English speakers (NES) in clinical trials contributes to health inequities and compromises the generalizability of research. Despite focus on this issue over the last decade, including the identification of barriers to enrollment, there has been little progress toward increasing enrollment. This study uses a modified Delphi method to reach consensus on best practice to overcome regulatory barriers and tests the resulting process in a simulated environment using principal investigators, research staff, interpreters and standardized patients.

PI_NAMEs: CHESSA, FRANK  (contact)

PROGRAM_OFFICER_NAME: HSIEH, JULIE

PROJECT_TITLE: INcreasing CLinical Trial OpportUnities anD Enrollment of Non-English Speaking Research Subjects: A Revised Research Pathway (INCLUDE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 OC-T (02)]


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE – OVERALL UNC CFAR The UNC Center for AIDS Research provides essential infrastructure support for the wide range of HIV related research for its members. This research contributes to the major goals of Ending the HIV Epidemic and HIV prevention and cure, and has overarching public health impact.

PI_NAMEs: SWANSTROM, RONALD I (contact)

PROGRAM_OFFICER_NAME: WONG, ELAINE WAI-KEN

PROJECT_TERMS: Abbreviations;Acquired Immunodeficiency Syndrome;AIDS prevention;Ally;Area;Award;Behavioral;biobehavior;Biological Specimen Banks;career;Caring;China;CLIA certified;Clinical;Clinical Data;Clinical Research;Clinical Sciences;cohort;Collaborations;Color;Communicable Diseases;Communities;community engagement;comorbidity;Comprehensive Cancer Center;Country;Development;Discipline;Distance Learning;Education;Educational Curriculum;Educational workshop;Enrollment;Ensure;Epidemic;Equity;equity, diversity, and inclusion;experience;Faculty;Family health status;Funding;global health;Goals;graduate student;Health;Historically Black Colleges and Universities;HIV;Immunology;Infrastructure;innovation;Interdisciplinary Study;Interest Group;International;Internships;Journals;Knowledge;Laboratories;Leadership;Learning;lectures;Libraries;Link;Malawi;Master of Public Health;Medical;medical schools;meetings;member;Mentors;Microbiology;North Carolina;novel therapeutics;outreach;Pathway interactions;Patients;Persons;Pharmacology;Physicians;prevent epidemics;programs;Public Health;Reporting;Research;Research Personnel;Research Support;Risk;Schools;Series;Site;South Africa;South Carolina;Strategic Planning;Students;summer research;System;Talents;Training;Translational Research;transmission process;undergraduate student;underrepresented minority student;Underrepresented Populations;United States Dept. of Health and Human Services;United States National Institutes of Health;Universities;Vietnam;virology;working group;Writing;Zambia

PROJECT_TITLE: The University of North Carolina Center for AIDS Research


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Administrative Supplement;Agriculture;Ally;Award;Belief;Biomedical Research;care providers;career;career development;Clinical Research;Collaborations;Communicable Diseases;community based research;community engagement;Critical Thinking;design;Development;diversity and equity;diversity and inclusion;Education;Educational Curriculum;effectiveness evaluation;Epidemic;equity, diversity, and inclusion;experience;Experimental Designs;experimental study;Faculty;Fostering;Funding;Generations;graduate student;hands-on learning;Health;health disparity;Historically Black Colleges and Universities;HIV;Immunology;improved;Individual;Infrastructure;Institution;interest;Internships;Journals;Knowledge;Laboratories;Learning;lectures;medical schools;Mentors;Methods;Microbiology;multidisciplinary;Names;next generation;North Carolina;novel;Pathway interactions;posters;Program Effectiveness;Program Evaluation;programs;Public Health Education;Research;Research Personnel;Research Project Grants;Science;scientific literacy;Scientist;Series;skill acquisition;skills;student participation;Students;summer program;summer research;symposium;Training;undergraduate student;Underrepresented Populations;Universities;university student;Visit


ADMINISTERING_IC: EB

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEW HAVEN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative The IEEE Medical Imaging Conference (MIC) aims to disseminate and foster new research in physics and bio-engineering methods in medical imaging. The conference covers a variety of medical imaging topics, including quantitative imaging, PET/SPECT techniques, image reconstruction, imaging in radiation therapy, portable imaging, multi-modality systems, new medical imaging technologies, CT/MR/optical/ultrasound, parametric/kinetic image modeling, and signal/image processing and modeling. One of the major objectives of the conference is the education and encouragement of young investigators. Therefore, this NIH R13 proposal seeks funding to provide grants for each of the next three years to graduate students and postdoctoral fellows based at US institutions to partially cover the costs of MIC conference registration or short course fees.

PI_NAMEs: EL FAKHRI, GEORGES  (contact);GROGG, KIRA

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: Academia;Area;Artificial Intelligence;Attention;Award;Biomedical Engineering;Canada;Clinical;Clinical Management;clinical practice;Collaborations;Communities;Computer software;Computing Methodologies;cost;Dedications;deep learning;design;Detection;detector;Development;Diagnosis;disability;Disabled Persons;Discipline of Nuclear Medicine;Disease Management;Education;Educational Activities;Educational workshop;Emission-Computed Tomography;Engineering;Evaluation;Exposure to;Fees;Fostering;Funding;Gamma Rays;Generations;Government;graduate student;Grant;high resolution imaging;Housing;Image;Image Analysis;image guided intervention;image processing;image reconstruction;imaging modality;imaging system;Imaging technology;Industrialization;Industry;innovation;Institution;instrumentation;interest;International;Japan;Joints;kinetic model;Kinetics;Lead;Learning;Machine Learning;Mathematics;Medical Care Costs;Medical Imaging;Medical Technology;meetings;member;Methods;Minority;Minority Groups;Modeling;models and simulation;Modernization;Monitor;multidisciplinary;Multimodal Imaging;multimodality;novel;Nuclear;nuclear science;Optics;Oral;Participant;particle therapy;Photons;Physics;portability;Positron-Emission Tomography;Postdoctoral Fellow;posters;programs;public education;quantitative imaging;radiation detector;Radiation therapy;Radionuclide therapy;reconstruction;Research;Research Personnel;Research Project Grants;Roentgen Rays;Running;Scientist;Semiconductors;signal processing;Signal Transduction;Standardization;statistics;Students;Suggestion;symposium;System;Techniques;Technology;Temperature;Therapeutic Intervention;tomography;Translations;ultrasound;Underrepresented Populations;United States National Institutes of Health;Woman;Work;X-Ray Medical Imaging

PROJECT_TITLE: IEEE Medical Imaging Conference


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

PHR: PROJECT NARRATIVE The Yale Liver Center is one of 17 Silvio O. Conte Digestive Diseases Research Core Centers (DDRCC) supported by the NIH/NIDDK and one of only three that focus on the study of liver structure, function, and disease. This supplement application aims to support the Annual DDRCC meeting to foster collaborations among centers and a scientific symposium for early-stage investigators to present their liver or digestive disease research. The symposium will also include opportunities for scientific feedback, career development, mentoring and networking for the early-stage investigators.

PI_NAMEs: NATHANSON, MICHAEL H (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Active Learning;Administrative Supplement;Administrator;Area;Autoimmune Diseases;base;Basic Science;bench to bedside;Biology;career;career development;Cholestasis;Cirrhosis;Clinical Research;clinical translation;clinically relevant;Collaborations;community center;Consumption;Core Facility;cost;Dedications;Diagnosis;Digestive System Disorders;Discipline;Disease;diversity and inclusion;Environment;Epithelium;Etiology;Event;Feedback;Fibrosis;Fostering;Funding;Genetic Diseases;Goals;Growth;Immunobiology;Infection;Inflammation;innovation;Institution;interest;Knowledge;Learning;Liver;Liver diseases;liver metabolism;Malignant neoplasm of liver;meetings;Mentors;Mission;Molecular;Morphology;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Nursing Faculty;Oral;Organizational Efficiency;Participant;Physiology;posters;Procedures;programs;Public Health;Research;research facility;Research Personnel;Scientist;Secure;Services;Structure;symposium;Techniques;Technology;Time;Training;training opportunity;Translational Research;translational study;Travel;United States National Institutes of Health;Universities;Voice;Work

PROJECT_TITLE: Yale Liver Center


ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative The New York City (NYC) Cancer Prevention and Control Research Network Collaborating Center (CPCRN) of the NYU-CUNY Prevention Research Center (PRC) aims to continue its collaborative work across the CPCRN network and employ social determinants of health (SDoH) strategies to reduce preventable cancers, increase early cancer screening and detection, and improve cancer equity among low-income, minoritized populations in urban areas. We propose conducting two core projects that will each leverage an established network of NYC community and clinical partners serving Asian American, Black, Latine, and other understudied immigrant communities in order to reduce cancer disparities and improve cancer control. The first is an implementation research evaluation to assess the impact of evidence-based strategies to improve uptake and adoption of lung cancer screening among high-risk, low-income racial and ethnic minoritized communities in NYC, and the second will conduct a formative research assessment to inform a multi-level, healthcare provider intervention to improve human papilloma virus (HPV) vaccine rates among high-risk and understudied communities in NYC.

PI_NAMEs: ISLAM, NADIA S;TRINH-SHEVRIN, CHAU  (contact)

PROJECT_TITLE: NYU-CUNY Prevention Research Center - Revision - 5- 24-003

STUDY_SECTION_NAME: Special Emphasis Panel[ZDP1 FMC (04)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: The proposed research is relevant to public health because it utilizes fully integrated survey methods, ecological momentary assessment, and passive assessments from smartphones to test the within-per- son bidirectional mechanisms that underlie online experiences and offline risk, resilience, and mental health among a clinical and non-clinical sample of adolescents as well as disparities by sex and for sex- ual and gender minority youth. This is a necessary next step to understanding the digital ecology of youth development and identifying potentially modifiable targets for interventions to prevent poor mental and behavioral health and promote resilience in the digital age. Thus, the proposed research is aligned with NIMH’s mission to transform the understanding and treatment of mental illnesses though basic and clini- cal research, paving the way for prevention, recovery, and cure.

PI_NAMEs: GABRIELLI, JOY ;LYNNE, SARAH DELPHIA (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Acute;Address;Adolescent;adolescent mental health;Affect;Age;Anecdotes;Area;Basic Science;Behavior;Behavioral;behavioral health;Cellular Phone;Clinic;Clinical;Clinical Research;cyberbullying;Data;Data Collection;data streams;Development;digital;Disease;Ecological momentary assessment;Ecology;Emotional;Emotions;Environment;Equation;evidence base;experience;Exposure to;Family;Female;Future;gender minority;gender minority youth;girls;Goals;Human;Human Resources;Internet;Intervention;intervention program;Knowledge;Language;Link;Literature;Maps;Mediation;Mental disorders;Mental Health;Mental health promotion;mental state;Methods;Mission;Modeling;Moods;Motivation;Music;National Institute of Mental Health;Natural Language Processing;Negative Finding;Outcome;Participant;Pathway interactions;Patient Self-Report;Periodicity;Personal Satisfaction;Persons;prevent;Prevention;Prevention program;preventive intervention;Problem behavior;Process;promote resilience;Public Health;Recovery;recruit;Research;Research Activity;resilience;Risk;Sampling;Schools;sex;Sex Differences;sex disparity;Sexual and Gender Minorities;sexual minority;sexual minority youth;Shapes;Sleep;social media;Social Network;Survey Methodology;Surveys;Symptoms;Testing;theories;therapy development;Time;trend;Well in self;Work;Youth

PROJECT_TITLE: Online and offline multiverse spillover: Mapping the ecology of youth mental health


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Comparative Effectiveness Research;Dementia;Health Services;Hypertension;Kidney Disease;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Patient Safety;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Chronic individuals dementias target project kidney disease (CKD) is a highly morbid disease t hat disproportionately affects older and is associated with a significantly increased risk of Alzheimer's and related (ADRD) compared to the genera l population. Research is needed to identify and t herapies towards older patients with CKD who are at high risk for ADRD. This proposed aims toutilize electronic health record data from the Veterans Health Administration linked with Medicare to estimate the effects of ARB- vs. ACEI-based medication regimens on incidence of ADRD using advanced causal inference methods and to apply machine learning methods to identify high-risk older adults, who may differentially benefit from therapy.

PI_NAMEs: BRESS, ADAM P;COHEN, JORDANA B. (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Affect;Alzheimer's disease related dementia;Alzheimer's disease risk;Angiotensins;Anti-Hypertensive Agents;Benign;Chronic;Clinical;Cluster Analysis;Cognitive;cognitive benefits;comparative effectiveness analysis;Data;Dementia;dementia risk;Development Plans;Disease;Electronic Health Record;experience;General Population;health record;Heart Diseases;high risk;Incidence;Individual;K-Series Research Career Programs;Kidney;Kidney Diseases;Laboratories;Learning;Link;machine learning method;Malignant Neoplasms;Manuscripts;Medicare;Methods;normal aging;older adult;older patient;Older Population;Outcome;Pathologic;Patients;Pharmaceutical Preparations;Phenotype;Population;Prevention;Public Health;Quality of life;Regimen;Renin;Research;Risk;senescence;Subgroup;System;targeted treatment;Techniques;Testing;Training;Vertebral column;Veterans Health Administration;Vulnerable Populations

PROJECT_TITLE: Informing optimal first-line antihypertensive therapy: A rigorous comparative effectiveness analysis of ARBs vs. ACEIs on long-term risk of dementia, cancer, heart disease, and quality of life


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Pediatric

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Adolescent mental health has worsened in recent years and increased time spent on social media is cited as a contributing factor. This study provides a prospective, high-resolution, multi-informant, and experimental test of bi-directional influences between young adolescents’ social media use and mental health symptoms. In doing so, the research is positioned to advance science, support adolescents, and respond to calls from policymakers, researchers, educators, and parents to better understand how social media engagement can impact adolescents’ mental health.

PI_NAMEs: ODGERS, CANDICE  (contact)

PROJECT_TERMS: 15 year old;Address;Adolescence;Adolescent;adolescent mental health;Adopted;Age;Anxiety;anxiety symptoms;application programming interface;boys;Caregivers;Clinical;Collaborations;Collection;cost;Data;depressive symptoms;Development;digital;early adolescence;Ecological momentary assessment;Evaluation;Exhibits;experience;experimental study;Exposure to;Female Adolescents;Future;girls;help-seeking behavior;Household;improvement on sleep;industry partner;informant;Intervention;Measures;media use;Mediating;Mental Depression;Mental disorders;Mental Health;Minority Groups;Modeling;Modification;novel;open source;Parents;Patient Self-Report;Persons;Policies;Policy Maker;Population;Positioning Attribute;Privacy;prospective;Randomized;Recording of previous events;reduce symptoms;Reporting;Research;Research Personnel;Resolution;Resources;response;Sampling;scaffold;Science;sleep quality;social;social media;socioeconomics;Subgroup;Symptoms;Testing;Time;wearable device;Youth

PROJECT_TITLE: Real-time and randomized tests of social media and mental health interplay in early adolescence


NIH_SPENDING_CATS: Biodefense and Related Countermeasures

PI_NAMEs: WOLOSCHAK, GAYLE E. (contact)

PROGRAM_OFFICER_NAME: WINTERS, THOMAS A


ADMINISTERING_IC: HL

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Nanotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MERCED

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA, MERCED

PHR: PROJECT NARRATIVE Patients with critical limb ischemia (CLI) patients continue to suffer from severely reduced quality of life and high mortality rates with revascularization remaining an important first line of treatment. Clinical trials of revascularization procedures and medical therapies, like angioplasty or bypass surgery, are associated with some improvement in subsequent amputation-free survival by about 6 months, but the quality of life assessments remain extremely low compared with normal population values. The proposed studies will deliver tip-specific endothelial cells (ECs) derived from pluripotent stem cells to direct the growth of new blood vessels in murine ischemic hind limbs to address this unmet need for patients with CLI.

PI_NAMEs: HUANG, NGAN F.;MCCLOSKEY, KARA E (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: Address;Amputation;Angioplasty;Biocompatible Materials;bioscaffold;Blood Vessels;Bypass;Cell Survival;Cell Therapy;Cells;Clinical Trials;Collagen;critical limb Ischemia;Death Rate;Endothelial Cells;Hindlimb;human induced pluripotent stem cells;improved;in vivo;induced pluripotent stem cell;Investigation;Ischemia;limb ischemia;Limb structure;Maintenance;Medical;mouse model;mRNA delivery;Mus;Muscle;nanopattern;new growth;Operative Surgical Procedures;Patients;Perfusion;PGF gene;Phenotype;Pluripotent Stem Cells;Population;Procedures;Quality of life;Quality of Life Assessment;Reproducibility;revascularization;Source;stem cells;success;Tissues;Transplantation

PROJECT_TITLE: Biomaterials for delivery and maintenance of tip endothelial cells


NIH_SPENDING_CATS: HIV/AIDS;Immunotherapy

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Not applicable

PI_NAMEs: YAO, CHEN  (contact)

PROGRAM_OFFICER_NAME: ZHOU, YAN

PROJECT_TITLE: Harnessing Stem-like CD8 T Cells for Immunotherapies to Eradicate HIV Reservoirs


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Serious Mental Illness

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative of Parent Grant The proposed research is relevant to public health because understanding of the neural mechanism by which meditation training improves emotional health in healthy and depressed adolescents is ultimately expected to help us develop safe and effective methods of treating and preventing adolescent depression. Thus, the proposed research is relevant to the part of NIH's mission to ensure that all youth have the chance to achieve their full potential for healthy and productive lives, free from disease or disability.

PI_NAMEs: YANG, TONY TUNG-I (contact)

PROGRAM_OFFICER_NAME: QUINLAN, ERIN BURKE

PROJECT_TERMS: Adolescence;Adolescent;adolescent health;Affect;Age;Anhedonia;Attenuated;Brain;Brain region;Caring;Characteristics;child depression;Clinical;Clinical Trials;cohort;comparison control;Compassion;connectome;Control Groups;Data;Depressed mood;depression prevention;depressive symptoms;design;Diffusion Magnetic Resonance Imaging;disability;Disease;effective intervention;effectiveness study;Emotional;expectation;experience;Goals;Happiness;Health;improved;indexing;innovation;Intervention;Knowledge;Literature;Love;Magnetic Resonance Imaging;Maps;Measures;Mediating;Meditation;Mental Depression;Methods;mindfulness meditation;Mindfulness Training;Mission;Modeling;myelination;neural;neurodevelopment;neuromechanism;novel;Outcome;parent grant;Participant;Patient Self-Report;Phase;pleasure;Population;positive emotional state;Prefrontal Cortex;prevent;Prevention;Primary Care;Productivity;Public Health;putamen;Questionnaires;Randomized;recruit;relapse prevention;Research;response;Sampling;Scanning;Severities;Symptoms;Techniques;Teenagers;Testing;Training;United States National Institutes of Health;Waiting Lists;Weight;white matter;Work;Youth

PROJECT_TITLE: Diversity Supplement: Neural mechanisms of meditation training in healthy and depressed adolescents: An MRI connectome study


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Telehealth;Women's Health Research

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: NARRATIVE Gestational diabetes rates rising, disproportionately affect people of color. We propose to study how to leverage patient-centered digital health interventions to improve care for diverse patients with GDM. Long-term goals are to prevent type 2 diabetes and other metabolic diseases in diverse maternal communities.

PI_NAMEs: BROWN, SUSAN DENISE (contact);FERRARA, ASSIAMIRA

PROGRAM_OFFICER_NAME: LINDER, BARBARA

PROJECT_TERMS: Adoption;Affect;Area;Behavior Therapy;Birth;Black Populations;Black race;black women;California;cardiometabolic risk;career;career development;Career Mobility;Caring;Center for Translational Science Activities;Client satisfaction;Clinical;Clinical Sciences;Clinical Trials;Communities;community engaged research;Data;Death Rate;Dedications;design;Developed Countries;Development;Development Plans;Diabetes Mellitus;Diabetes prevention;digital;digital health;digital intervention;Equity;Evaluation;evidence base;experience;Familiarity;Fortification;Foundations;Funding;Future;Gestational Diabetes;Goals;Guidelines;Health;health equity;Health Professional;Health system;Healthcare;high risk;improved;Individual;Intervention;Intervention Trial;Manuscripts;Maternal health equity;maternal morbidity;Maternal Mortality;Medical Students;Mentors;Mentorship;Metabolic Diseases;Methodology;mhealth interventions;mortality risk;neglect;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Outcome;outreach program;parent grant;parent project;Parents;Participant;patient engagement;patient oriented;Patients;Peer Review;people of color;Perinatal;Persons;Physicians;Population;Population Heterogeneity;Populations at Risk;Postpartum Period;Pregnancy;Preparation;prevent;preventable death;preventive intervention;Procedures;process evaluation;Productivity;professional students;Publications;randomized, clinical trials;Recommendation;Research;Research Activity;research and development;Research Project Grants;Research Training;Resources;Review Literature;Risk;Risk Reduction;Scientist;symposium;Target Populations;Testing;timeline;TNFSF15 gene;Training;Translational Research;United States National Institutes of Health;Universities;White Women

PROJECT_TITLE: Optimizing a scalable intervention to maximize guideline-recommended diabetes testing after GDM - Diversity Supplement


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Dietary Supplements;Mental Health;Mental Illness;Microbiome;Neurosciences;Nutrition;Pediatric;Prevention;Serious Mental Illness

ORG_CITY: SAN FRANCISCO

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because understanding the mechanism of action by which probiotics reduce adolescent depressive symptoms will lead to the development of safe and effective methods for treating and preventing adolescent depression.

PI_NAMEs: LEUNG, CHERRY  (contact);YANG, TONY TUNG-I

PROGRAM_OFFICER_NAME: WEBER, WENDY J

PROJECT_TERMS: 15 year old;Adherence;Administrative Supplement;Adolescence;Adolescent;adolescent-onset depression;Adult;Affect;Age;Bacteria;Biological;Brain;child depression;Clinical;clinical diagnosis;clinical practice;clinical remission;Consensus;Data;Depressed mood;depressed patient;Depressive disorder;depressive symptoms;design;Development;Diagnosis;dietary supplements;disability;Dose;efficacy trial;Engineered Probiotics;Exhibits;Female;Formulation;Functional Magnetic Resonance Imaging;Future;Gastrointestinal tract structure;Genetic Materials;gut dysbiosis;gut microbiome;gut microbiota;gut-brain axis;Hippocampus;hypothalamic-pituitary-adrenal axis;improved;innovation;insight;Intake;Intervention;Knowledge;Lactobacillus;Left;Literature;male;Mental Depression;Mental Health;Methods;microbiome composition;microbiota;microorganism;Neurosecretory Systems;Outcome;parent grant;Pathway interactions;Patients;Phase;physical conditioning;placebo group;Placebos;Practice Guidelines;Predisposition;Prevalence;prevent;Prevention;probiotic therapy;Probiotics;Public Health;Publishing;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research;Rest;Safety;Severities;Structure;Testing;tetrahydrobiopterin;timeline;treatment group;Youth

PROJECT_TITLE: Administrative Supplement to Probiotic Administration for Adolescent Depression


NIH_SPENDING_CATS: Bioengineering;Brain Cancer;Brain Disorders;Cancer;Genetics;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: PHARMACOLOGY

ORG_NAME: STANFORD UNIVERSITY

PI_NAMEs: GRAY, NATHANAEL SCHIANDER (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Acids;Acute;Adoption;age group;Amides;Amino Acids;analog;Animals;aspirate;Binding;Biochemical;biochemical model;Biological;Biological Assay;Biological Models;Biology;blood-brain barrier penetration;Brain;Brain Neoplasms;Breast;cancer cell;Cancer Prognosis;Carbamates;Carbon;Categories;Cell Line;Cell model;Cells;Cellular Assay;Chemicals;Chemistry;chemoproteomics;Chemotherapy and/or radiation;Child;Childhood;Childhood Solid Neoplasm;chimeric antigen receptor T cells;Chimeric Proteins;Chromatin;Chromatin Remodeling Factor;Chromosomal translocation;Clinical;clinical implementation;Clinical Trials;Collaborations;Coupled;Coupling;CRISPR screen;CRISPR/Cas technology;Crystallization;Crystallography;Cysteine;Data;Dependence;design;Development;Dimerization;Disease;Down-Regulation;drug development;Drug Exposure;Drug Targeting;drug testing;early phase clinical trial;Electrons;Engineering;Ependymoma;Equilibrium;Ethers;Evaluation;Event;Ewings sarcoma;EWS-FLI1 fusion protein;Exhibits;expectation;Family member;flexibility;follow-up;Fusion Oncogene Proteins;Future;Gastrointestinal Neoplasms;Generations;Genes;Genetic;Genetic Transcription;Glioma;Glues;glutarimide;Goals;high risk;Histones;Homeostasis;Human;improved;In Vitro;in vivo;Individual;Indoles;inhibitor;innovation;insight;interest;Intervention;Label;Laboratories;Lead;lenalidomide;Length;leukemia;Libraries;Ligands;Lung;Maleimides;Malignant Childhood Neoplasm;Malignant neoplasm of central nervous system;Malignant Neoplasms;MAPK8 gene;MAPK9 gene;Mass Spectrum Analysis;Measurement;Mediating;member;MEN1 gene;Menin;Messenger RNA;Methods;Methylation;MLL gene;Modeling;Modification;Molecular;Molecular Conformation;Molecular Mechanisms of Action;mortality;Mus;Mutate;Mutation;neural;Neuroblastoma;neuroblastoma cell;Neuroepithelial, Perineurial, and Schwann Cell Neoplasm;Normal tissue morphology;novel;Nuclear Export;Oncogenic;Oncoproteins;patient engagement;Patient Representative;Patients;Pediatric Neoplasm;Pediatric Oncology;Peptides;Periodicity;Permeability;personalized approach;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacology;Phase;Phenotype;Phosphotransferases;pi bond;Polyethylene Glycols;pomalidomide;pre-clinical;Process;Production;programs;promoter;Property;protein degradation;Protein Inhibition;protein protein interaction;Proteins;Protocols documentation;prototype;Pyrimidine;Reaction;Reagent;Recombinant Proteins;Recombinants;RELA gene;Reporter;Reporting;Research Personnel;Resistance;resistance mechanism;Resources;Risk;Roentgen Rays;Route;scaffold;Scaffolding Protein;screening;Series;Serine;Side;small molecule;small molecule inhibitor;Solid;Solid Neoplasm;structural biology;Structure;success;Succinimides;Survival Rate;synovial sarcoma;System;tertiary amine;Testis;Thalidomide;Therapeutic;Threonine;Time;Toxicology;transcription factor;Triage;TRIM Motif;tumor;Tumor Biology;ubiquitin-protein ligase;Urea;Vaccinia;Validation;Work;X-Ray Crystallography;Zinc Fingers

PROJECT_TITLE: PROTECT - Harnessing PROTEin degradation for Advanced Childhood Tumors


ORG_CITY: LAS CRUCES

ORG_NAME: NEW MEXICO STATE UNIVERSITY LAS CRUCES

ORG_STATE: NM

PHR: PROJECT NARRATIVE Nitric oxide (NO) is an important signaling molecule that mediates interactions between the host and bacterial pathogens. Vibrio cholerae, the causative agent of cholera, expresses two putative NO-sensor proteins that are likely important for virulence and biofilm formation within the host, although this has never been evaluated largely due to the lack of appropriate animal models for cholera disease. This collaborative project will use a novel human intestinal organoid model as well as in vitro biofilm characterization and advanced proteomics to determine NO sensor function and mechanism in V. cholerae with implications for the development of improved cholera treatments.

PI_NAMEs: LUSETTI, SHELLEY  (contact)

PROGRAM_OFFICER_NAME: MATUKUMALLI, LAKSHMI KUMAR

PROJECT_TERMS: Address;Affect;Animal Model;anti-microbial drug;Applications Grants;Area;Bacteria;base;Behavior;Binding Proteins;Biological Models;Biomass;Biomedical Research;career;Cells;chemical reaction;Cholera;Coculture Techniques;Collaborations;commune;Complex;confocal imaging;Core Facility;cytokine;Data;Development;diarrheal disease;Disease;enteric infection;Epithelium;Etiology;Event;experience;Experimental Models;experimental study;Fluids and Secretions;follow-up;Follow-Up Studies;Funding Opportunities;Future;gastrointestinal;Gene Expression Profiling;Genes;Glass;Goals;Helicobacter Infections;Heme;High Pressure Liquid Chromatography;Human;human disease;Immune;Immune response;Immunobiology;improved;In Vitro;Individual;Infection;insight;intestinal crypt;intestinal epithelium;Intestines;Investigation;Laboratories;Macrophage;Mammals;Manuscripts;Maps;Mass Spectrum Analysis;Measures;Mediating;Mediator;Methods;Microbial Biofilms;Microscopy;Modeling;Modernization;monocyte;Montana;Mucous Membrane;multidisciplinary;mutant;Nevada;New Mexico;Nitric Oxide;Nitric Oxide Donors;Nitric Oxide Signaling Pathway;NOS2A gene;novel;Organism;Organoids;Oxygen;parent project;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathway interactions;Periodicity;Phenotype;phosphoproteomics;phosphoric diester hydrolase;Phosphorylation;Physiological;Play;Positioning Attribute;Postdoctoral Fellow;Prevention;Process;Production;programs;protein-histidine kinase;Proteins;Proteome;Proteomics;Pseudomonas aeruginosa;Publishing;quorum sensing;Research;Resistance;Resolution;Resources;response;Role;Science;sensor;Signal Pathway;Signal Transduction;Signaling Molecule;Signaling Protein;Source;Stains;Stomach;Structure;Students;System;targeted treatment;Teacher Professional Development;Testing;Therapeutic Uses;Training;training opportunity;transcriptome sequencing;transcriptomics;undergraduate student;United States National Institutes of Health;Universities;Up-Regulation;Vibrio cholerae;Vibrio cholerae infection;Virulence;Work

PROJECT_TITLE: New Mexico IDeA Networks of Biomedical Research Excellence (INBRE)


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Support development of promising therapies for neurological disorders

PI_NAMEs: KAUFMAN, JULIA  (contact)

PROJECT_TERMS: Area;Development;Nervous System Disorder;operation;Performance;Pharmacology and Toxicology;programs;small molecule;Therapeutic

PROJECT_TITLE: PERFORMANCE AREA 1 - MANAGEMENT AND OPERATIONS SUPPORT


ORG_CITY: MENLO PARK

ORG_NAME: SRI INTERNATIONAL

PHR: Developing therapies for neurological disorders

PI_NAMEs: HO, LYNNE  (contact)

PROJECT_TERMS: Area;Drug Kinetics;Nervous System Disorder;operation;Performance;Pharmacology and Toxicology;programs;Rodent;Therapeutic;therapy development

PROJECT_TITLE: SRI 2023 RODENT AND NON-RODENT PHARMACOKINETIC STUDIES


ADMINISTERING_IC: IP

IC_NAME: NATIONAL CENTER FOR IMMUNIZATION AND RESPIRATORY DISEASES

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE ENHANCED SURVEILLANCE NETWORK (ESN) MANDATORY CORE The Enhanced Surveillance Network (ESN) will provide a national network of pediatric inpatient, emergency department and outpatient surveillance sites to advance the health of children by determining the disease burden and epidemiology of enteric and respiratory viruses including rotavirus, norovirus, influenza, RSV, parainfluenza viruses, human metapneumoviruses, rhinoviruses, enteroviruses (including EV-D68), adenoviruses and coronaviruses (including SARS-CoV-2). Within the framework of this network the impact of the US Rotavirus, Influenza and SARS-CoV-2 Immunization Programs will be monitored by assessing the effectiveness of these vaccines and examining the impact on the epidemiology of these diseases pre- and post-licensure. The ESN will also conduct surveillance for acute flaccid myelitis and multisystem inflammatory syndrome in children (MIS-C) to determine the incidence, clinical features and risk factors for these conditions.

PI_NAMEs: STAAT, MARY A (contact)

PROJECT_TITLE: IP21-002 US Enhanced Surveillance Network to Assess Burden, Natural History, and Effectiveness of Vaccines to Prevent Enteric and Respiratory Viruses in Children


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE – Mandatory Component A Continuing our established surveillance systems for pediatric acute respiratory illness (ARI) and acute gastroenteritis (AGE) within the New Vaccine Surveillance Network at Monroe Carell Jr Children's Hospital at Vanderbilt, we will determine population-based rates of viral ARI due to common etiologies (e.g., RSV, influenza, metapneumovirus, rhinovirus, adenovirus, parainfluenza viruses, and coronaviruses [including severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2)] and viral AGE due to common etiologies (e.g., rotavirus and norovirus) among children residing in Davidson County, TN. We will enroll children <18 years from inpatient and emergency department settings who present with fever and/or respiratory symptoms (ARI) or who have a history of vomiting or diarrhea (AGE) and collect nose/throat or stool specimens, respectively. We will identify individuals with acute flaccid myelitis (AFM) and define epidemiologic features, clinical characteristics, and risk factors of AFM in the surveillance area.

PI_NAMEs: HALASA, NATASHA BASSAM (contact)

PROJECT_TITLE: IP21-002 Enhanced Surveillance for New Vaccine Preventable Diseases


ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: NARRATIVE (For Components A, B, and C) Acute gastroenteritis (AGE) and acute respiratory illness (ARI) are leading causes of childhood disease, accounting for a large proportion of hospitalizations and medically attended visits annually in the US. Moreover, several viral causes of AGE and ARI are associated with important emerging childhood syndromes, including enteroviruses with acute flaccid myelitis (AFM) and SARS-CoV-2 with multisystem inflammatory syndrome in children (MIS-C). We propose to conduct active, prospective, population-based surveillance to define the disease burden of these viruses, determine population-based incidence, characterize clinical features, course, and outcomes, and establish vaccine effectiveness of licensed and pending vaccines; the results will inform public health policies and interventions.

PI_NAMEs: MICHAELS, MARIAN G (contact)

PROJECT_TITLE: IP21-002, New Vaccine Surveillance Network


ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: We will perform population-based surveillance for infectious pathogens in emergency department and hospitalized pediatric patients and asymptomatic healthy controls who live in King and Snohomish Counties, WA and receive care for acute respiratory and enteric disease at Seattle Children’s Hospital, a regional medical center caring for hospitalized children in the Seattle metropolitan area. We will capture demographic characteristics, interview parents and collect electronic medical record information describing clinical and laboratory findings, vaccine uptake, and prospectively collect clinical specimens to characterize viral pathogens using sensitive standardized molecular assays. We will describe the epidemiology and incidence of disease in our catchment area, the burden of disease and assessment of vaccine effectiveness or impact of other interventions.

PI_NAMEs: ENGLUND, JANET A (contact);KLEIN, EILEEN

PROJECT_TITLE: IP21-002, Enhanced Surveillance to Assess Vaccine Preventable Enteric and Respiratory Virus Illnesses


ORG_CITY: KANSAS CITY

ORG_NAME: CHILDREN'S MERCY HOSP (KANSAS CITY, MO)

ORG_STATE: MO

PHR: Component A: Project Narrative The Kansas City-New Vaccine Surveillance Network site proposes to conduct prospective, active surveillance of children with symptomatic respiratory or gastrointestinal illness in the emergency department and inpatient settings, children with acute flaccid myelitis (AFM) and asymptomatic control children for the next five years. The project goal is to detect the infectious causes of respiratory and gastrointestinal illnesses, identify the clinical syndromes and disease burden associated with these pathogens, and assess the effectiveness of licensed/upcoming vaccines, immunoprophylaxis, and therapeutics against respiratory and gastrointestinal illnesses as well as determine the baseline rates and clinical spectrum of AFM and compare its rates to pathogens causing respiratory and gastrointestinal illness. This network will inform public health authorities on priorities and policies relating to vaccine development and prevention and provide timely and highly useful data for public health interventions against these diseases in children.

PI_NAMEs: SCHUSTER, JENNIFER E;SELVARANGAN, RANGARAJ  (contact)

PROJECT_TITLE: IP21-002, US Enhanced Surveillance Network to Assess Burden, Natural History, and Effectiveness of Vaccines to Prevent Enteric and Respiratory Viruses in Children


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative: Components A, B, and C  The over-arching goal of the Rochester NVSN site is to inform the nation about the burden of vaccine- preventable diseases, and the impact of new vaccines and vaccine policies upon the healthcare and health outcomes of children in the US. To accomplish this, we will enhance our ongoing population-based surveillance for acute respiratory and gastrointestinal infections in children in the hospital, in emergency departments, and in doctors' offices. By combining precisely collected medical information from infected children's charts, parent interviews, and molecular testing of nasal and stool samples, we can accurately define the causes of respiratory and gastrointestinal disease, in order to better formulate vaccine policies and study conditions such as influenza, RSV, rotavirus, norovirus, and SARS-CoV-2.

PI_NAMEs: WEINBERG, GEOFFREY ALAN (contact)

PROJECT_TITLE: IP21-002, Enhanced Surveillance Network for Enteric and Respiratory Viruses in Children: Assessing Disease Burden, Natural History, and Vaccine Effectiveness


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Mental Health;Neurosciences

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC FOUNDATION

PI_NAMEs: CIERI, FILIPPO  (contact)

PROGRAM_OFFICER_NAME: ZHOU, YANG

PROJECT_TERMS: 10 year old;Adaptive Behaviors;Aging;Amyloid;Attention;Behavior;brain health;Centers of Research Excellence;Characteristics;Childhood;Clinic;Cognitive;Creativeness;Dorsal;Education;Environment;executive function;flexibility;Foundations;Functional Magnetic Resonance Imaging;Graph;Health;higher education;Hippocampus;human old age (65+);Individual;Inflammation;innovation;Learning;Leisure Activities;Life;Literature;Maintenance;Measures;mild cognitive impairment;Nerve Degeneration;Neurocognitive;neurophysiology;Neuropsychological Tests;Neuropsychology;Outcome;Pathology;Patient Recruitments;Patients;Peripheral;Phase;Population;Problem Solving;protective factors;resilience;Rest;Risk;Risk Factors;Role;segregation;sex;Short-Term Memory;social;standard measure;Testing;Time;Woman

PROJECT_TITLE: Beyond Reserve: Dynamic Neurocognitive Adaptation


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: INDIANAPOLIS

ORG_NAME: RLR VA MEDICAL CENTER

ORG_STATE: IN

PHR: PROJECT NARRATIVE  Objective molecular correlates (biomarkers) of suicide risk would make a significant difference in our ability to diagnose and treat suicidality in veterans, eliminating subjectivity and reliance on patient’s self- report of symptoms. Blood gene expression studies have emerged as a particularly interesting area of research in the search for peripheral biomarkers. We propose to conduct such studies as a way of accelerating the discovery of clinical useful universal biomarkers at the interface of TBI and suicidality.

PI_NAMEs: NICULESCU, ALEXANDER B (contact)

PROJECT_TERMS: Acceleration;Acute;Animal Model;Animals;Area;Award;Behavioral;Biological Markers;biomarker identification;Blood;Blood specimen;Brain;Clinical;clinical application;clinically relevant;Cognitive;Data;Diagnosis;Diagnostic;Disease;Drug abuse;Enrollment;Evaluation;experimental study;FDA approved;follow-up;Foundations;frontal lobe;Functional disorder;functional genomics;Gene Expression;Genes;genomic data;Glial Fibrillary Acidic Protein;high risk;Human;human imaging;human model;human subject;ideation;IL6 gene;Image;imaging study;Impulsive Behavior;Impulsivity;Individual;Inflammation;Inflammatory;inpatient psychiatric treatment;Inpatients;Interferon Type II;Link;longitudinal design;Mental Depression;Military Personnel;Molecular;neural circuit;neurobehavioral test;Neurobiology;neuroinflammation;Neurons;New Jersey;Patient Self-Report;Peripheral;phenomics;Prevention;psychiatric inpatient;Rattus;Recording of previous events;Research;response;Risk;Risk Factors;Sampling;secondary analysis;Series;Serotonergic System;Serotonin;Site;Stress;Study models;Study Subject;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;Symptoms;TBI Patients;Testing;trait;Transcript;transcriptomics;Traumatic Brain Injury;UCHL1 gene;Veterans;Visit

PROJECT_TITLE: CTBI: Traumatic brain injury-induced inflammation effects on cognitive evaluations and response inhibition: Mechanisms of increased risk for suicidality


ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PI_NAMEs: WOLOSCHAK, GAYLE E. (contact)


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Networking and Information Technology R&D (NITRD)

ORG_CITY: LONDON

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: UNIVERSITY COLLEGE LONDON

ORG_ZIPCODE: WC1E 6BT

PI_NAMEs: QUEZADA, SERGIO  (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Address;algorithm development;Algorithms;alpha-beta T-Cell Receptor;Antigen Presentation;Antigen Targeting;Antigens;Biochemical;cancer therapy;cancer type;cohort;Collection;combinatorial;Complement;Computer Models;Computing Methodologies;cytotoxicity;Data;Data Set;design;Development;Engineering;Event;exome sequencing;extend lifespan;Face;Feedback;Generations;Goals;Grant;Human;immune checkpoint blockade;Immune response;Immune system;Immunity;Immunology;Immunotherapy;improved;insight;Institution;large scale data;Lung;Machine Learning;Malignant neoplasm of lung;Malignant Neoplasms;Melanoma;method development;Methods;Modeling;Molecular;mouse model;next generation;Non-Small-Cell Lung Carcinoma;novel drug class;Patients;Peptide/MHC Complex;personalized medicine;Pharmaceutical Preparations;Primary Neoplasm;quantum;Research Personnel;response;Source;Specificity;structural biology;Structure;System;T cell response;T cell therapy;T-Cell Antigen Receptor Specificity;T-Cell Receptor;T-cell receptor repertoire;T-Cell Receptor Therapy;T-Lymphocyte;Testing;Therapeutic;therapy design;Toxic effect;Training;training data;transcriptome sequencing;tumor;Tumor Antigens;Tumor-Infiltrating Lymphocytes;Uncertainty;Vision;Work

PROJECT_TITLE: MATCHMAKERS - large-scale generation of reactive TCR-pMHC pairs from human NSCLC


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hematology;Liver Disease;Rare Diseases;Sickle Cell Disease

ORG_CITY: MILWAUKEE

ORG_NAME: VERSITI WISCONSIN, INC.

ORG_STATE: WI

PHR: Project Narrative Hepatic crisis affects 10-40% of hospitalized sickle cell disease (SCD) patients, which is characterized by liver injury and cholestasis that can progress to fatal liver failure. The current treatment for hepatic crisis in SCD is primarily supportive, and the molecular mechanism is largely unknown. This proposal will determine novel inflammatory and nuclear receptor signaling pathways that may serve as useful therapeutic targets for the future treatment of Sickle cell hepatobiliary injury.

PI_NAMEs: PRADHAN-SUNDD, TIRTHADIPA  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Affect;Age;Agonist;American;Apical;apical membrane;Area;autosome;Award;bile acid transporter;Bile Acids;Bile fluid;Biochemical;Biochemistry;career;Cholestasis;Chronic;chronic liver injury;Experimental Models;faculty research;Future;Genes;Genetic;Genetic Diseases;Goals;Hematology;Hemoglobin;Hemolysis;Hemolysis Induction;Hepatic;Hepatobiliary;Hepatocyte;Hepatomegaly;Hospitalization;Human;human disease;humanized mouse;Hyperbilirubinemia;Immunohistochemistry;Impairment;improved;In Vitro;in vivo;in vivo imaging;Incidence;Inflammation;Inflammatory;Injury;Institution;Intrahepatic Cholestasis;Ischemia;life span;Liver;liver biopsy;Liver diseases;Liver Failure;Liver Fibrosis;liver injury;medical schools;meetings;Mendelian disorder;Mentors;Mentorship;Modeling;Molecular;mouse model;multi-photon;Mus;NF-kappa B;novel;Nuclear Receptors;Oncology;Outcome;Oxidative Stress;Pathway interactions;Patients;Persons;Preventive therapy;prognostic;Proteins;recessive genetic trait;Reperfusion Injury;Reporting;Research;Research Personnel;Research Training;Role;Sampling;Scientist;Secondary to;Serum;sex;Sickle Cell;Sickle Cell Anemia;sickling;Signal Pathway;Signal Transduction;Sterility;Testing;Therapeutic;therapeutic target;Time;tissue injury;Tissues;Toxic effect;Training;transcriptome sequencing;Transgenic Organisms;United States National Institutes of Health;Universities

PROJECT_TITLE: Molecular Mechanism of Sickle Cell Hepatic Crisis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Immunotherapy;Networking and Information Technology R&D (NITRD)

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PI_NAMEs: DEKOSKY, BRANDON JAMES (contact)

PROJECT_TERMS: Address;algorithm development;Algorithms;Alleles;alpha-beta T-Cell Receptor;Antigen Presentation;Antigen Targeting;Antigens;B-Lymphocytes;Benchmarking;Binding;Biochemical;cancer therapy;cancer type;Cell Line;Clonal Expansion;Cloning;Collection;combinatorial;Computer Models;Computing Methodologies;cost;cytotoxicity;Data;Data Set;design;Development;Engineering;Epitopes;Event;expression vector;extend lifespan;Face;Feedback;Generations;Genetic Screening;Goals;Grant;high throughput screening;High-Throughput Nucleotide Sequencing;Human;immune checkpoint blockade;Immune response;Immune system;Immunity;Immunology;Immunotherapy;improved;Individual;insight;Institution;large scale data;Libraries;Machine Learning;Malignant neoplasm of lung;Malignant Neoplasms;Melanoma;method development;MHC antigen;Mining;model development;Modeling;Molecular;mouse model;neoantigens;next generation;Non-Small-Cell Lung Carcinoma;novel;novel drug class;Output;Patients;Peptide/MHC Complex;personalized medicine;Pharmaceutical Preparations;Population;preservation;Proteins;quantum;Recombinants;Research Personnel;response;Sampling;screening;Sorting;Source;Specificity;structural biology;Structure;System;T cell receptor repertoire sequencing;T cell response;T cell therapy;T-Cell Antigen Receptor Specificity;T-Cell Receptor;T-cell receptor repertoire;T-Cell Receptor Therapy;T-Lymphocyte;Techniques;Technology;Testing;Therapeutic;therapy design;Thymus Gland;Toxic effect;Training;training data;tumor;Tumor Antigens;Tumor-Infiltrating Lymphocytes;Uncertainty;Variant;Vision;Work;Yeasts

PROJECT_TITLE: MATCHMAKERS - Solving T-cell receptor recognition and design via integrated high-throughput screening and structural, functional and computational approaches


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Immunotherapy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: OSLO

ORG_COUNTRY: NORWAY

ORG_FIPS: NO

ORG_NAME: OSLO UNIVERSITY HOSPITAL, RIKSHOSPITALET

PI_NAMEs: OLWEUS, JOHANNA  (contact)

PROJECT_TERMS: Address;algorithm development;algorithm training;Algorithms;Antibodies;Antigen Presentation;Antigen Targeting;Antigen-Presenting Cells;Antigens;Biochemical;cancer therapy;cancer type;Cell Line;Collection;combinatorial;Complex;Computer Models;Computing Methodologies;Coupled;cross reactivity;cytotoxicity;Data;Data Set;design;Development;Engineering;Epitopes;Event;extend lifespan;Face;Feedback;Generations;Goals;Grant;high throughput screening;HLA Antigens;Human;immune checkpoint blockade;Immune response;Immune system;Immunity;Immunology;Immunotherapy;improved;insight;Institution;large datasets;large scale data;Machine Learning;Magnetism;Malignant neoplasm of lung;Malignant Neoplasms;Melanoma;method development;Microspheres;Modeling;Molecular;mouse model;Names;Natural Immunity;next generation;novel drug class;Peptide/MHC Complex;Peptides;personalized medicine;Pharmaceutical Preparations;Physiological;Proteins;quantum;Reporter;Research Personnel;response;Source;Specificity;structural biology;Structure;Synthetic immunology;System;T cell response;T cell therapy;T-Cell Antigen Receptor Specificity;T-Cell Receptor;T-cell receptor repertoire;T-Cell Receptor Therapy;T-Lymphocyte;Technology;Testing;Therapeutic;therapy design;Thymus Gland;Toxic effect;Training;training data;tumor;Tumor Antigens;Uncertainty;Vaccination;Viral;Vision;Work

PROJECT_TITLE: MATCHMAKERS - SOLVING TCR RECOGNITION AND DESIGN VIA INTEGRATED HIGH-THROUGHPUT SCREENING, STRUCTURAL, FUNCTIONAL, AND COMPUTATIONAL APPROACHES


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Cocaine;Comparative Effectiveness Research;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Health Services;Maternal Health;Maternal Morbidity and Mortality;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Stimulant Use and Misuse;Substance Misuse;Women's Health Research

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Clinical guidelines recommend medication treatment of opioid use disorder during pregnancy to improve fetal and maternal outcomes, but there are critical gaps in our understanding of the comparative safety and effectiveness of alternative treatment options. Using nationwide cohorts of publicly and commercially insured pregnancies, we will examine newly emerging questions related to the impact of co-exposure to other psychoactive substances, the surge in fentanyl in the drug supply, the safety of naltrexone, and modifiable factors affecting treatment retention. The resulting evidence will help guide providers toward optimal treatment choices for individual patients and will identify factors that can be intervened upon directly to improve retention in treatment, a critical aspect of successful substance use disorder treatment.

PI_NAMEs: BATEMAN, BRIAN THOMAS;HUYBRECHTS, KRISTA F (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: addiction;Address;Admission activity;Affect;Age;alcohol use disorder;alternative treatment;Amphetamines;Benzodiazepines;Buprenorphine;Caring;Cesarean section;Characteristics;Clinical;Cocaine;cocaine use;Cocaine use disorder;cohort;comorbidity;comparative effectiveness;comparative safety;Complex;Congenital Abnormality;Data;Databases;Diagnosis;Discipline of obstetrics;Dose;Epidemiologic Methods;experience;Exposure to;Fentanyl;fetal;General Population;Guidelines;Gynecology;High Prevalence;high risk;Home;illicit opioid;improved;individual patient;Injectable;innovation;Inpatients;Internal Medicine;Low Birth Weight Infant;marijuana use disorder;maternal outcome;maternal risk;Measures;Medicaid;medical specialties;medication for opioid use disorder;Mental disorders;Methadone;methadone treatment;Modification;Naltrexone;Neonatal Abstinence Syndrome;neonatal outcome;non-opioid analgesic;opioid use;opioid use disorder;optimal treatments;Oral;Outpatients;Overdose;overdose death;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pharmacotherapy;Pharmacy facility;Planned Pregnancy;Population;Postpartum Period;Pregnancy;pregnant;Premature Birth;Prevalence;Provider;Recommendation;reproductive;Research;retention rate;Risk;Risk Reduction;Safety;Schedule;Selective Serotonin Reuptake Inhibitor;Service delivery model;severe maternal morbidity;Small for Gestational Age Infant;Spontaneous abortion;stillbirth;stimulant use;substance misuse;Substance Use Disorder;Suspensions;Testing;treatment choice;Treatment Protocols;treatment strategy;trend;United States;Update;Woman

PROJECT_TITLE: The Comparative Effectiveness and Safety of Pharmacotherapies for the Treatment of Opioid Use Disorder in Pregnancy


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Disability Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Mental Health;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

ORG_STATE: NH

PHR: PROJECT NARRATIVE Opioid misuse affects almost 700,000 women of reproductive age in the United States, and infants exposed to opioids during pregnancy are more likely to be born preterm, small for their gestational age, and to develop neonatal opioid withdrawal syndrome. Beyond infancy, outcomes in opioid exposed infants are poorly understood, especially in Hispanic and non-White populations. This research will rapidly address this knowledge gap, identifying neurodevelopmental and health outcomes in opioid-exposed children during the critical period of birth until five years of age, characterizing disparities in these outcomes on the basis of maternal race, ethnicity, rurality and disability, and identifying health system factors that may be protective, thereby informing clinical and public health interventions to support this vulnerable population.

PI_NAMEs: LEYENAAR, JOANNA  (contact)

PROGRAM_OFFICER_NAME: VIDAL, SARAH

PROJECT_TERMS: 5 year old;Address;Adult;Affect;Age;behavioral health;Birth;Birth Certificates;Black race;Caring;Characteristics;Child;Child Care;Child Health;Child health care;Chronic;Client;Clinical;Clinical Research;clinically relevant;Cohort Analysis;Community Services;Complex;complex chronic conditions;Confounding Factors (Epidemiology);Congenital Abnormality;critical period;Data;Data Scientist;Data Set;Development;Diagnosis;Diagnostic;disability;Disabled Persons;Discipline of obstetrics;Disparity;Disparity in diagnosis;early childhood;Education;Ensure;ethnic diversity;ethnic minority population;Ethnic Origin;experience;Exposure to;Fetal Growth;Fetal Growth Retardation;fetal opioid exposure;gastrointestinal symptom;Geography;Gestational Age;Goals;Guidelines;Health;health care disparity;Health Services;Health system;Healthcare;Hispanic;hospital care;Hospitalization;Hospitals;improved;Incidence;infancy;Infant;Infant Mortality;intergenerational;Knowledge;Life;Link;Maternal and Child Health;Maternal Health Services;Medicaid;Medical;Mental Health;mortality;mortality risk;multidisciplinary;multilevel analysis;National Institute of Drug Abuse;Neonatal Abstinence Syndrome;neonatal care;Neurologic Symptoms;Newborn Infant;Not Hispanic or Latino;Nutritional Support;opioid exposure;opioid misuse;opioid use disorder;opioid use in pregnancy;Outcome;Parents;Patient Self-Report;Persons;Pharmacy facility;physical abuse;Policies;Policy Maker;Population;postnatal;postnatal period;Poverty;Pregnancy;pregnant;Premature Birth;Prevalence;programs;protective factors;Public Health;public health intervention;Race;racial diversity;racial minority population;racism;Recording of previous events;Reporting;reproductive;Research;Research Personnel;Risk;Rural;rurality;Series;Severity of illness;Sexual abuse;social;social factors;Special Supplemental Nutrition Program for Women, Infants, and Children;Strategic Planning;Structure;Texas;United States;Variant;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Disparities in early childhood health outcomes following prenatal opioid exposure and protective health system factors: a population perspective


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Networking and Information Technology R&D (NITRD);Social Determinants of Health

ORG_CITY: Pretoria

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF PRETORIA

PI_NAMEs: DLAMINI, ZODWA  (contact)

PROGRAM_OFFICER_NAME: ROTUNNO, MELISSA

PROJECT_TERMS: Adopted;Africa;African;African ancestry;Air Pollution;anti-cancer research;Automation;biobank;Biological;black patient;Blood specimen;Budgets;cancer health disparity;cancer risk;Chromatography;cloud based;cohort;Collaborations;Communities;Complex;computer framework;Computer software;Data;Data Element;data repository;Databases;early onset;Environment;environmental chemical;Environmental Exposure;Epigenetic Process;Equity;Gas Chromatography;Genetic;genome sequencing;Genomics;Geography;Germ Lines;Green space;Immunoassay;Immunologic Factors;Immunologics;improved;Incidence;industry partner;Inequality;Link;Liquid Chromatography;Lived experience;Machine Learning;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;marginalized population;Mass Spectrum Analysis;Measurement;Measures;member;Methods;Molecular;novel;novel strategies;outcome disparities;Participant;Pathway interactions;Patient advocacy;Patient Self-Report;Patients;Persons;Phase;Plasma;Policies;Population;precision oncology;Predisposition;Preparation;Primary Neoplasm;Procedures;profiles in patients;racism;Research;Research Personnel;Resolution;Resources;response;Sampling;Science;Scientist;Site;small molecule;social;social determinants;Surveys;sustainability framework;Technology;Training;transcriptomics;treatment and outcome;trial design;tumor;Tumor Tissue;Underserved Population;virtual;wasting;whole genome;Work

PROJECT_TITLE: Societal, Ancestry, Molecular AND Biological Analyses Of Inequalities (SAMBAI)