NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Disability Research;Pain Research;Pediatric

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE - RELEVANCE Gastroparesis and functional dyspepsia affect both children and adults, is responsible for great morbidity, and is associated with increased mortality. Little is understood regarding the epidemiology, causes, and natural history of these disorders in adults but the knowledge void is even greater in children. The results of this proposal will provide novel insights into their clinical expression and course in children.

PI_NAMEs: CHUMPITAZI, BRUNO PEDRO;PREIDIS, GEOFFREY A (contact)

PROJECT_TERMS: Adolescent;Adult;Affect;age difference;age group;age related;Anxiety;Assessment tool;Caring;Categories;Child;Childhood;children's depression inventory;Clinical;Clinical Research;Clinical Sciences;Clinical Trials;cohort;common symptom;comorbidity;cost;Data;Development;Diabetes Mellitus;dietary;Dietitian;disability;Disease;Distress;Duodenum;Dyspepsia;early satiety;Eating Behavior;eosinophil;Epidemiology;Epigastrium;Equipment and supply inventories;Etiology;field study;Food;functional disability;Functional disorder;Functional Gastrointestinal Disorders;Future;Gastric Emptying;Gastritis;gastrointestinal;Gastroparesis;General Population;Goals;Hospitalization;Hypersensitivity;improved;Incidence;innovation;insight;interdisciplinary approach;Intestinal permeability;Knowledge;Link;mast cell;Measures;Mechanics;Mental Depression;Methodology;Methods;Morbidity - disease rate;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;Nausea and Vomiting;neuropathology;novel;Obstruction;Operative Surgical Procedures;Outcome Assessment;Pain;pain catastrophizing;Parents;Patients;pediatric patients;Population;Prevalence;prospective;Psychologist;psychosocial;Quality of life;Questionnaires;Radionuclide Imaging;recruit;Registries;Research;Role;Sample Size;Satiation;Severities;Severity of illness;Site;Stomach;Symptoms;Testing;Toddler;trait;transition to adulthood;Treatment outcome;Validation;Visceral;Vomiting;Water;Work

PROJECT_TITLE: Advancing Clinical Science in Pediatric Gastroparesis


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Atherosclerosis;Biotechnology;Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: PORTLAND

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PATHOLOGY

ORG_FIPS: US

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Cardiovascular disease and dementia are major health problems, particularly in the elderly population. Vascular pathologies across all vasculature are linked to dementia of all causes, particularly the two major subtypes, Alzheimer’s dementia (AD) and vascular dementia (VaD). The current application seeks to fill the scientific gaps by uncovering a novel function of smooth muscle cell (SMC)-expressed Runx2 in regulating cardio/cerebrovascular pathologies and VaD, and developing a novel paradigm underlying the Runx2-dependent signaling network in regulating SMC phenotypic switch. Results from these studies should also have important clinical implications in developing potential strategies for maintaining vascular integrity and improving cognitive function and quality of life. PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page

PI_NAMEs: CHEN, YABING  (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Acceleration;Address;age acceleration;age related;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;Aneurysm;Animal Model;Aorta;Apolipoprotein E;APP-PS1;arterial stiffness;Arteries;Atherosclerosis;atherosclerosis risk;Biochemical;Bioinformatics;Blood flow;Blood Vessels;Brain;brain dysfunction;calcification;Cardiovascular Diseases;cardiovascular risk factor;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;cerebrovascular pathology;Cerebrovascular system;Cerebrum;Clinical;Clinical Management;Clinical Treatment;cognitive function;Coronary Arteriosclerosis;Dementia;Development;Disease;Elderly;genetic risk factor;Genetic Transcription;genome-wide analysis;Goals;Health;High Fat Diet;Human;human tissue;Hypertension;Impaired cognition;improved;In Vitro;in vivo;insight;Ischemic Stroke;Knowledge;Link;Localized Lesion;Mediating;Molecular;molecular array;mouse model;multidisciplinary;multiple omics;Mus;normal aging;novel;novel strategies;Nutrient;old mice;Organ;Outcome;Oxygen;Pathogenesis;Pathology;Peripheral arterial disease;Phenotype;Play;Population;pre-clinical;Proteomics;Quality of life;Regulation;Reporting;Resources;risk variant;Role;Serum Response Factor;Signal Transduction;single-cell RNA sequencing;Smooth Muscle Myocytes;Stroke;synergism;Systemic disease;Testing;Tissues;tool;transcription factor;treatment strategy;Up-Regulation;Vascular calcification;Vascular Dementia;Vascular Diseases

PROJECT_TITLE: Novel regulation of vascular dementia

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ADMINISTERING_IC: DK

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Digestive Diseases;Microbiome

ORG_CITY: EL PASO

ORG_NAME: TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER AT EL PASO

ORG_STATE: TX

PHR: Project Narrative Gastroparesis affects approximately 10% of the US population, with patients suffering with chronic, severe and difficult to control symptoms of nausea, vomiting, inability to finish normal size meal, fullness and abdominal pain. The NIH GpCRC has generated an extensive number of individual studies, which have increased our knowledge and concepts of understanding of this condition, its complications, diagnostic challenges and clinical outcomes. As the next step in the continuation of our research, we are proposing two new clinical projects: 1- Investigate whether the composition of the gut microbiota, in the stomach and duodenum of GP patients differs in idiopathic, compared to diabetic etiologies and control patients; and 2- investigate how a new medication, utilizing the mechanism of 5 Hydroxytryptamine (5HT) stimulation by a selective 5HT4 receptor agonist, which is already FDA approved for constipation, may help to reduce symptoms of gastroparesis as well as accelerate gastric emptying while having a satisfactory profile adverse event.

PI_NAMEs: MCCALLUM, RICHARD WARWICK (contact);SAROSIEK, IRENE

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Abdominal Pain;Acceleration;Adverse event;Adverse reactions;Affect;Agonist;Antral;Biopsy;Buspirone;capsule;Chronic;Clinical;clinical care;Clinical Research;Clinical Trials;clinically relevant;cohort;Constipation;Control Groups;design;diabetic;diabetic gastroparesis;Diagnosis;Diagnostic;Diagnostic tests;diagnostic value;Dissection;Double-Blind Method;Duodenum;dysbiosis;efficacy evaluation;Endoscopy;Enrollment;Etiology;Exhibits;FDA approved;Functional disorder;Gastric Emptying;gastric microbiota;Gastroparesis;Grant;gut microbiota;Immunologics;improved;Individual;insight;Investigation;Knowledge;Large Intestine;laxative;Medical;meetings;Methodology;Methods;microbiota;microbiota composition;Motility;Mucous Membrane;National Institute of Diabetes and Digestive and Kidney Diseases;Nausea;Operative Surgical Procedures;Outcome;Pathogenesis;Pathologic;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;pharmacologic;Placebo Control;Placebos;Population;Protocols documentation;Pyloric sphincter structure;Qualifying;Radionuclide Imaging;Randomized;randomized placebo controlled trial;Reaction;receptor;Recommendation;reduce symptoms;Registries;Research;Research Design;response;Role;Safety;Sampling;Serotonin;Serotonin Receptors 5-HT4;Severities;Small Intestines;Smooth Muscle;Stomach;Subgroup;Submucosa;symptomatic improvement;Symptoms;Testing;Time;Tissue Sample;Tissues;treatment duration;Treatment Efficacy;United States National Institutes of Health;Upper digestive tract structure;Vomiting;wireless

PROJECT_TITLE: A multicenter, double-blind, randomized, placebo- controlled, parallel study to assess the efficacy of 5- HT4 agonist prucalopride for the treatment of diabetic and idiopathic gastroparesis


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: SALT LAKE CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Uterine cancer is the only cancer type with worse outcomes today than in the 1970s; serous uterine cancer is the deadliest subtype and it disproportionally effects black women. Tumor treatment response and outcomes are impacted not only by cancer cells, but also by cells in their microenvironment. To better understand serous uterine cancer, we will profile the tumor and microenvironment of patient samples following treatment.

PI_NAMEs: ULRICH, CORNELIA M (contact)

PROGRAM_OFFICER_NAME: SHAFIK, HASNAA

PROJECT_TERMS: Accounting;Address;Administrative Supplement;Affect;Age;age effect;Atlases;black women;cancer cell;cancer type;Carcinoma;Caring;cell behavior;Cell Communication;cell type;Cells;Cessation of life;checkpoint therapy;Clinical Trials;Communities;Data;Data Set;Disease;Endometrioid Carcinoma;Endometrium;Endothelial Cells;Evaluation;Exhibits;falls;Fibroblasts;Foundations;Future;Gene Expression;Gene Expression Profile;Goals;Gynecologic Oncology;Hormonal Change;Hormone Responsive;Hormones;Immune;Immune checkpoint inhibitor;Immunotherapy;improved;improved outcome;Incidence;interest;Invaded;Lead;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Molecular and Cellular Biology;mortality;Myometrial;neoplastic cell;novel;novel therapeutic intervention;Outcome;Ovarian hormone;Patient-Focused Outcomes;Patients;Population;Portraits;Prediction of Response to Therapy;predictive marker;response;Sampling;Serous;single-cell RNA sequencing;success;Surveys;Survival Rate;targeted treatment;Treatment outcome;treatment response;tumor;tumor microenvironment;Tumor stage;Tumor Subtype;Uterine Cancer;Uterus;Woman;women's diagnosis;Work

PROJECT_TITLE: Evaluation of the tumor microenvironment in serous uterine cancers


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Data Science;Diabetes;Machine Learning and Artificial Intelligence

ORG_CITY: LA JOLLA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE As the use of a wide array of methods that generate large amounts of complex data become more common in Diabetes research, the data and prior knowledge about the disease contain critical, but hidden, information relevant to addressing the challenge. The NIDDK Information Network (dkNET) AI to Accelerate Diabetes Research Pilot program will bring new and diverse AI experts into the T2D research workforce, new AI models that other T2D researchers can use, and informative use cases of the new models.

PI_NAMEs: CHEN, SHUIBING ;GRETHE, JEFFREY S. (contact);LI, CHEN ;WANG, WEI

PROGRAM_OFFICER_NAME: XIA, ASHLEY

PROJECT_TERMS: Acceleration;Address;artificial intelligence model;Bioinformatics;Biomedical Research;Cloud Computing;Communities;community engagement;complex data;computing resources;Data;Data Science;Development;Diabetes Mellitus;Disease;Foundations;Heterogeneity;Information Networks;Knowledge;Methods;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;Phase;programs;Research;Research Personnel;Techniques;Validation

PROJECT_TITLE: dkNET Coordinating Unit: Harnessing the Power of AI and Data Science forCollaborative Discovery and Sharing in the DK Community


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: NEW YORK

ORG_NAME: INTERNATIONAL AIDS VACCINE INITIATIVE

ORG_STATE: NY

PI_NAMEs: HASSEL, THOMAS  (contact)

PROJECT_TERMS: Adjuvant;Biological Products;Clinical Research;Clinical Trials;Communicable Diseases;Contracts;Cyclic GMP;Development;Development Plans;Human;Influenza;influenza virus vaccine;manufacture;novel vaccines;Phase;product development;Services;System;United States Food and Drug Administration;vaccine delivery;vaccine development;Vaccines

PROJECT_TITLE: Task V02: Manufacture of Influenza for Human Challenge Clinical Trials


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: MISSOULA

ORG_NAME: UNIVERSITY OF MONTANA

ORG_STATE: MT

PI_NAMEs: EVANS, JAY  (contact)

PROJECT_TERMS: absorption;Adjuvant;Antigens;Aspergillus fumigatus;Bordetella pertussis;Candida albicans;Cells;Chemistry;Clinical Trials;combat;Contractor;Contracts;Development;Drug Kinetics;efficacy study;Excretory function;Family suidae;Formulation;Human;Humoral Immunities;Immune response;Immunity;immunogenicity;improved;Investigation;Ligands;manufacture;Mediating;Metabolism;Modeling;mouse model;Mus;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;nanoparticle delivery;National Institute of Allergy and Infectious Disease;nonhuman primate;novel;novel vaccines;pathogen;pathogenic bacteria;pathogenic fungus;Production;programs;Property;Pseudomonas aeruginosa;receptor;research clinical testing;Rodent;Safety;Staphylococcus aureus;Streptococcus pneumoniae;Structure-Activity Relationship;System;thermostability;Toxicology;Trehalose;Vaccination;Vaccine Adjuvant;Vaccines

PROJECT_TITLE: DEVELOPMENT OF UM-1098: A NOVEL SYNTHETIC TH17 INDUCING ADJUVANT AND DELIVERY SYSTEM


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: La Jolla

ORG_NAME: SCRIPPS INSTITUTION OF OCEANOGRAPHY

PI_NAMEs: LAPEK, JENNIFER  (contact)

PROJECT_TERMS: Adjuvant;Agonist;Animal Model;Animals;Chronic Disease;Clinical Trials;Communicable Diseases;Contractor;cross immunity;Development;dosage;Drug Kinetics;efficacy study;Elderly;Fluzone;Formulation;Frequencies;Human;Immune;Immunization;immunogenicity;improved;Individual;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H3N2 Subtype;Influenza B Virus;influenza virus strain;influenza virus vaccine;influenzavirus;manufacture;Modeling;Mus;novel vaccines;old mice;Patients;Prevention;protective efficacy;Route;safety study;seasonal influenza;small molecule;Structure-Activity Relationship;Support Contracts;System;TLR4 gene;TLR7 gene;Toxicology;Vaccine Adjuvant;Vaccines

PROJECT_TITLE: DEVELOPMENT OF SMALL-MOLECULE DUAL ADJUVANT SYSTEM FOR INFLUENZA VIRUS VACCINE


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PI_NAMEs: NORTON, ELIZABETH  (contact)

PROJECT_TERMS: Adjuvant;ADP ribosylation;Antigens;Back;Biological Sciences;Campylobacter;Contractor;cross reacting material 197;Cyclic GMP;Development;Dose;enteric infection;enterotoxigenic Escherichia coli;Enterotoxins;Evaluation;Food;Formulation;gastrointestinal;Goals;Human;Human poliovirus;Immunity;immunogenicity;manufacture;Mucosal Immunity;Mucous Membrane;mutant;novel;Oral;Phase I Clinical Trials;Phase II Clinical Trials;Poliomyelitis;Poliovirus Vaccines;Preparation;Recording of previous events;Research;Route;Saponins;Soapbush;Source;South American;stability testing;stool sample;success;Toxicology;Toxin;Trees;Vaccination;Vaccine Adjuvant;Vaccines

PROJECT_TITLE: DEVELOPMENT OF SAPONIN DMLT ADJUVANT (SDA)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_NAME: INIMMUNE CORPORATION

PI_NAMEs: BURKHART, DAVID  (contact)

PROJECT_TERMS: absorption;Adjuvant;Agonist;Antibodies;Antigens;Bacterial Vaccines;Chemistry;Collaborations;Contractor;Contracts;Cyclic GMP;Development;Drug Kinetics;Excretory function;Exhibits;Ferrets;flu;Formulation;Generations;Head;Immune response;immunogenicity;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H3N2 Subtype;Influenza B Virus;influenza virus vaccine;Lead;manufacture;Metabolism;Modeling;novel;pre-clinical;Proteins;QS21;Recombinants;Safety;Saponins;scale up;seasonal influenza;System;T-Lymphocyte;TLR4 gene;Toxicology;Vaccine Adjuvant;Vaccines;Viral Vaccines

PROJECT_TITLE: DEVELOPMENT OF SAS A SYNTHETIC AS01-LIKE ADJUVANT SYSTEM FOR INFLUENZA VACCINES


NIH_SPENDING_CATS: Biotechnology;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PI_NAMEs: TSUJI, MORIYA  (contact)

PROJECT_TERMS: Adjuvant;Antigens;Attenuated;Binding;Bite;Contractor;Contracts;Culicidae;Cytotoxic T-Lymphocytes;Data;efficacy study;Formulation;Future;gene gun;Glycolipids;Goals;Human;immunogenicity;Liver;Malaria Vaccines;manufacture;mouse model;Mus;nonhuman primate;novel;Nucleic Acids;Parasites;product development;Publishing;Radiation;RNA replication;RNA vaccine;Safety;Solubility;Sporozoites;Toxicology;Vaccine Adjuvant;Vaccine Antigen;vaccine strategy;vaccine trial;Vaccines

PROJECT_TITLE: A GLYCOLIPID ADJUVANT 7DW8-5 FOR MALARIA VACCINES


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Obesity;Patient Safety;Prevention;Women's Health Research

ORG_CITY: CINCINNATI

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PI_NAMEs: THOMAS, MICHAEL  (contact)

PROJECT_TERMS: Clinical Trials Network;Conduct Clinical Trials;Contraceptive Agents;Contraceptive methods;Development;Female Contraceptive Agents;Future;Goals;Medical;Methods;Mission;National Institute of Child Health and Human Development;Obesity;product development;Program Development;protocol development;Protocols documentation;Risk Reduction;Services;Site;unintended pregnancy;venous thromboembolism;Woman

PROJECT_TITLE: CCTN-CONTRACEPTIVE DEVELOPMENT PROGRAM – CORE FUNCTION ACTIVITIES FOR SITES OF FEMALE CONTRACEPTIVE STUDIES - CINCINNATI


ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PI_NAMEs: CREININ, MITCHELL  (contact)

PROJECT_TITLE: CCTN-CONTRACEPTIVE DEVELOPMENT PROGRAM – CORE FUNCTION ACTIVITIES FOR SITES OF FEMALE CONTRACEPTIVE STUDIES - UC DAVIS


ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PI_NAMEs: KANESHIRO, BLISS E (contact)

PROJECT_TERMS: Clinical Trials Network;Conduct Clinical Trials;Contraceptive Agents;Contraceptive methods;Development;Female Contraceptive Agents;Future;Goals;Hawaii;Medical;Methods;Mission;National Institute of Child Health and Human Development;Obesity;product development;Program Development;protocol development;Protocols documentation;Risk Reduction;Services;Site;unintended pregnancy;venous thromboembolism;Woman

PROJECT_TITLE: CCTN-CONTRACEPTIVE DEVELOPMENT PROGRAM – CORE FUNCTION ACTIVITIES FOR SITES OF FEMALE CONTRACEPTIVE STUDIES - HAWAII-MANOA


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vector-Borne Diseases

ORG_CITY: SEATTLE

ORG_NAME: ACCESS TO ADVANCED HEALTH INSTITUTE

ORG_STATE: WA

PI_NAMEs: VOIGT, EMILY  (contact)

PROJECT_TERMS: Advanced Development;Animal Model;biodefense;Chikungunya virus;Clinical;Communicable Diseases;Contracts;Disease Outbreaks;efficacy evaluation;efficacy testing;Emerging Communicable Diseases;Formulation;immunogenicity;Individual;Infection;manufacture;response;Safety;stability testing;therapeutic candidate;therapeutic development;Toxicology;vaccine development;Vaccines

PROJECT_TITLE: Development of Therapeutic Candidates for Biodefense, Infections and Emerging Infectious Diseases


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

ORG_STATE: NC

PHR: “This study is part of the NIH’s Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to understand the basis of pain and enhance clinical pain management.”

PI_NAMEs: HAYES, KATIE  (contact)

PROJECT_TERMS: clinical pain;Contractor;Contracts;Development;Drug Addiction;Evaluation;Helping to End Addiction Long-term;Medical;National Institute of Drug Abuse;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;Neurotoxins;Pain;Pain management;Pharmaceutical Preparations;Poison;programs;repository;Research;research and development;Research Support;Resources;Schedule;screening;Specific qualifier value;Speed;Substance Abuse Detection;Testing;Therapeutic;United States National Institutes of Health

PROJECT_TITLE: PURITY SPECIFICATIONS, STORAGE, AND DISTRIBUTION FOR MEDICATIONS DEVELOPMENT CONTRACT


NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Neurosciences;Pain Research;Prevention

PI_NAMEs: RUNYON, SCOTT P (contact)

PROJECT_TITLE: PURITY SPECIFICATIONS, STORAGE, AND DISTRIBUTION FOR MEDICATIONS DEVELOPMENT CONTRACT. JULY 9, 2022 - JULY 8, 2027


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Data Science

ORG_CITY: PARKTOWN

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: WITS HEALTH CONSORTIUM (PTY), LTD

PHR: The use of dashboards by district health officials to understand and visualize complex health data is a key outcome of MADIVA; the effectiveness of these dashboards depends on data visualization literacy. We will assess levels of data literacy among key stakeholders and develop interventions to improve the ability of nurses and district health officials in African countries to use data science methods, and in particular to use our dashboards.

PI_NAMEs: HAZELHURST, SCOTT  (contact);KYOBUTUNGI, CATHERINE ;RAMSAY, MICHELE MICHELE;TOLLMAN, STEPHEN

PROGRAM_OFFICER_NAME: NEWSOME, BRAD

PROJECT_TITLE: MADIVA  (Multimorbidity in Africa: Digital innovation, visualisation and application)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(70)-R]


NIH_SPENDING_CATS: Bioengineering;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Sexually Transmitted Infections;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative mHealth may facilitate the wider introduction of human papillomavirus-based cervical cancer screening programs in low- and middle-income countries such as Kenya by supporting specimen and patient tracking, patient education, service reminders and counseling support. We propose to develop and evaluate the impact of an integrated digital platform with a mobile application for use by community health volunteers (CHVs), building on a prototype developed to address gaps in CHV-led cervical cancer screening programs identified in previous work in the region. The study will also help determine the impact of a mobile application to support cervical cancer prevention services in Kenya, as well as the personnel and infrastructure needs and implementation strategy for scale-up and sustainability in similar low-resource settings.

PI_NAMEs: HUCHKO, MEGAN J. (contact)

PROGRAM_OFFICER_NAME: PEARLMAN, PAUL C

PROJECT_TERMS: acceptability and feasibility;Address;Adopted;Africa South of the Sahara;age group;aged;arm;Cancer Burden;Cancer Control;cancer risk;Case Management;Cellular Phone;cervical cancer prevention;Cervical Cancer Screening;Clinic;Clinical;Cluster randomized trial;Collaborations;Communities;Community Health;Computerized Medical Record;cost;Counseling;Country;Data;Data Collection;Decision Making;design;Development;digital;digital health;digital platform;Education and Outreach;Effectiveness;effectiveness clinical trial;effectiveness evaluation;effectiveness trial;effectiveness/implementation design;effectiveness/implementation study;Electronics;Eligibility Determination;Ensure;evidence base;experience;falls;Focus Groups;follow-up;Future;Guidelines;Health;Health care facility;Health system;Healthcare;Human Papilloma Virus Vaccination;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human Resources;implementation determinants;implementation facilitators;implementation strategy;improved;Individual;Information Management;Infrastructure;innovation;International;Intervention;Interview;Kenya;Knowledge;Laboratories;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Measures;mHealth;mobile application;Modeling;Morbidity - disease rate;mortality;open source;Patient Education;Patients;Performance;Phase;Pilot Projects;Play;prevent;Prevention;Prevention program;prevention service;Prevention strategy;Process;Program Effectiveness;Program Evaluation;programs;Protocols documentation;prototype;Provider;randomized, clinical trials;Recommendation;recruit;reproductive;Research;Research Design;Resource-limited setting;risk perception;Role;Sampling;scale up;screening;screening program;Services;Specimen;Surveys;System;Technology;Test Result;Testing;Time and Motion Studies;tool;Training;Underserved Population;United States;uptake;usability;Vaccination;volunteer;Woman;women's treatment;Work;World Health Organization

PROJECT_TITLE: mSaada: A Mobile Health Tool to Improve Cervical Cancer Screening in western Kenya

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-J(56)]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Neurodegenerative;Neurosciences

ORG_CITY: BATON ROUGE

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

PHR: NARRATIVE Many hearing and language disorders arise from pathological alterations to the central auditory pathways. This study is relevant to public health since it will investigate the hitherto overlooked contralateral auditory tectothalamic pathways as a neural substrate in these disorders. Therefore, this research is relevant to part of NIH’s mission, since it develops the basic knowledge that will lead to improved methods for diagnosing, preventing, and treating auditory disorders associated with aging, development, trauma, and neurodegeneration.

PI_NAMEs: LEE, CHARLES C (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustics;Affect;Aging;Auditory;auditory pathway;auditory processing;auditory stimulus;Auditory system;auditory thalamus;Behavior;behavioral impairment;Bilateral;Binaural;Binding;Brain;Brain Stem;cell type;Cells;Central Auditory Processing Disorder;Contralateral;Development;Diagnosis;Diagnostic;diagnostic development;diagnostic strategy;Disease;Ear;Equilibrium;Esthesia;experience;experimental study;Failure;Future;Glutamates;Goals;Health;Hearing problem;Impaired cognition;Impairment;improved;In Vitro;in vivo;Inferior;Inferior Colliculus;information processing;Injections;innovation;Investigation;Ipsilateral;Knowledge;Language Disorders;Lasers;life span;Light;Link;Medial geniculate body;Mediating;Methods;Midbrain structure;Mission;Modernization;Mus;Nerve Degeneration;neural;neural circuit;Neuroanatomy;neuromechanism;Neurons;neurophysiology;normal hearing;optogenetics;Outcome;Pathologic;Pathway interactions;Pattern;Physiological;Population;Presbycusis;prevent;Preventive measure;Process;Productivity;Property;prospective;Public Health;Quality of life;Research;response;Role;Scanning;Scheme;Signal Transduction;Slice;Societies;sound;Source;source localization;Stimulus;Structure;Synapses;System;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Tinnitus;Tracer;Trauma;United States National Institutes of Health;Viral

PROJECT_TITLE: Bilateral integration of the auditory scene

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Atherosclerosis;Hematology;Infectious Diseases;Lung;Rare Diseases;Sepsis

ORG_CITY: MOBILE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTH ALABAMA

ORG_STATE: AL

PHR: My career and long-term research goals are to establish an independent academic research program to identify novel signaling mechanisms regulating microvascular endothelial hyperpermeability during sepsis that can be targeted therapeutically for treatment of sepsis-induced organ dysfunction. The proposed research and training in this application will provide a foundation for my career as an independent academic investigator and position me well to achieve my goal of becoming a leader in mechanistic and

PI_NAMEs: MEEGAN, JAMIE E (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Acute Lung Injury;Acute Respiratory Distress Syndrome;Antibodies;Apoptotic;Atherosclerosis;Binding;Blood Vessels;Cardiovascular Diseases;career;cell injury;Cells;Cessation of life;Clinical;clinically relevant;CREB Activation Signaling Pathway;CREB1 gene;Data;Edema;endothelial dysfunction;Endothelium;Erythrocytes;Foundations;Functional disorder;Generations;Goals;Haptoglobins;Hemoglobin;Human;Immune response;Infection;Inflammation Mediators;Inflammatory;inhibitor;Injections;Injury;Lectin Receptors;Link;Low Density Lipoprotein oxidation;Lung;lung injury;lung microvascular endothelial cells;MAP Kinase Gene;Measures;Mediating;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;new therapeutic target;novel;Organ;Oxidants;oxidation;oxidized LDL receptors;oxidized low density lipoprotein;p38 Mitogen Activated Protein Kinase;Pathogenesis;Pathologic;Pathway interactions;Patients;Peptide Hydrolases;Permeability;Plasma;Plasma Cells;polymicrobial sepsis;Positioning Attribute;Prevention strategy;programs;receptor;Receptor Signaling;Regulation;Research;Research Personnel;Role;Sepsis;septic patients;Signal Pathway;Signal Transduction;Small Interfering RNA;systemic inflammatory response;targeted treatment;Testing;Training;treatment strategy;Up-Regulation;Vascular Endothelial Cell;Vascular Endothelium

PROJECT_TITLE: Cell-free hemoglobin-oxidized LDL-LOX-1 axis and microvascular hyperpermeability during sepsis

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Endocrine Disruptors;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: RELEVANCE (See instructions):  Metals and PFAS are neurotoxic, however, nutritional modifiers of their effects on neurodevelopmental disorder diagnoses remain unclear let  alone how to minimize chemical toxicities on human health. This study will investigate the roles of nutritional modifiers of chemicals -  neurodevelopmental disorders relationship, and predict the effects of hypothetical interventions to reduce chemical neurotoxicity. Our findings will  inform interventions and policies to promote children’s mental health and well-being.

PI_NAMEs: CHOI, GIEHAE  (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Address;advanced analytics;Affect;Allergic;analytical method;Attention deficit hyperactivity disorder;autism spectrum disorder;Awareness;Biological Assay;Biological Markers;Birth;Boston;Brain;career;Chemical Exposure;Chemical Modifier;chemical reduction;Chemicals;Child;Child Health;Child Mental Health;clinical diagnosis;cohort;Communication;comorbidity;critical period;Data;Detection;Development;Diagnosis;Dietary Intervention;Dietary Practices;Economic Burden;Electronic Health Record;Environment;Environmental Epidemiology;Environmental Health;Epidemiologist;ethnic diversity;Etiology;European;Exposure to;fetal;Folic Acid;Foundations;Future;gastrointestinal;Goals;Health;Health Care Costs;Heavy Metals;Heterogeneity;Human;improved;in utero;innovation;Instruction;Intervention;intervention effect;Joints;Lead;life span;Link;Literature;Low income;Maternal Exposure;Medical;Metabolic Diseases;Metal exposure;Metals;Methods;Minority;Modeling;Multivitamin;Neurodevelopmental Disability;Neurodevelopmental Disorder;neurotoxic;neurotoxicity;Neurotoxins;nutrition;Nutrition Assessment;Nutritional;offspring;Outcome;Personal Satisfaction;Phase;Phenotype;Policies;Policy Maker;Poly-fluoroalkyl substances;Population;Positioning Attribute;Pregnancy;prenatal exposure;prevent;Problem behavior;prospective;Prospective Studies;Public Health;Public Policy;Quality Control;racial diversity;Research;Research Personnel;Resources;Risk;Risk Factors;Role;Science;Solid;System;Technical Expertise;Time;Toxic effect;Training;Translational Research;Translations;Update;Vitamin B 12;Vitamin D

PROJECT_TITLE: Maternal exposure to chemicals and offspring neurodevelopmental disabilities: informing public health actions by understanding nutritional modifiers and simulating interventions


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: Princeton

ORG_DEPT: CHEMISTRY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative (Public Health Relevance Statement) Formaldehyde is a major environmental toxin and carcinogen whose aberrant exposure is connected to diseases spanning liver and cardiovascular disorders, cancer, diabetes, and neurodegeneration, but at the same time the body continually produces this reactive carbonyl species during normal physiology. We are developing and applying new chemical reagents for selective imaging and proteomics of formaldehyde in living systems to identify its molecular sources and targets, with the long-term goal of understanding how this reactive small molecule contributes both to normal physiology and disease.

PI_NAMEs: CHANG, CHRISTOPHER J. (contact)

PROGRAM_OFFICER_NAME: CUI, YUXIA

PROJECT_TITLE: Chemical Probes to Study Formaldehyde Biology

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ORG_CITY: CLEVELAND

ORG_DEPT: NUTRITION

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Obesity and obesity-related diseases have become one of the greatest threats to human health and a tremendous financial burden for individuals and societies. NLRP3 inflammasome-mediated inflammation in obesity has been recognized to promote the occurrence and progression of obesity-related diseases. The proposed research is of great health relevance because it will pave the way for translating dietary exosome-like nanoparticles and their active biomolecules into an intervention to curb inflammation in obesity.

PI_NAMEs: YU, JIUJIU  (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Allium schoenoprasum;Anti-Inflammatory Agents;Biological Availability;Cause of Death;Cells;chemical reduction;Chemical Structure;Chemicals;Chronic;clinical practice;combat;Complex;Development;Diet;diet-induced obesity;dietary;Dietary Fats;Disease;Disease Progression;Dose;Edible Plants;exosome;feeding;Financial Hardship;Fruit;Gene Expression;gene function;Goals;Health;Heart Diseases;High Fat Diet;Human;improved;Individual;Inflammasome;Inflammation;inhibitor;Innate Immune System;innovation;Intervention;Lipids;lipophilicity;Macrophage;Manuscripts;Mediating;Membrane;Metabolic;Milk;Modality;Mus;nanocarrier;nanoparticle;Non-Insulin-Dependent Diabetes Mellitus;Nutraceutical;Obesity;Obesity associated disease;Oral;Oral Administration;Outcomes Research;particle;Patients;Persons;Phosphorylcholine;Pilot Projects;prevent;Progressive Disease;Proteins;Research;Risk;RNA;Role;sensor;Societies;Stroke;Testing;Therapeutic;Therapeutic Effect;Tissues;Translating;translational applications;translational potential;Translations;United States;Vegetables;Work

PROJECT_TITLE: Role of chive-derived exosome-like nanoparticles in suppressing inflammation in obesity

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Rare Diseases

ORG_CITY: ATLANTA

ORG_DEPT: NEUROSURGERY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The overarching goal of this proposal is to advance a large animal model of spinal cord glioma (SCG) as a translational platform. We will accomplish this by scaling and adapting previously implemented strategies for vector- driven gene transfer of oncogenes and shRNA knockdown of genes implicated in gliomagenesis to induce SCG of variable phenotype. This will provide improved utility for preclinical therapeutic testing and surgical device development with varied grade, growth rate, and underyling genetic lesions.

PI_NAMEs: BOULIS, NICHOLAS M (contact);CANOLL, PETER

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: Address;Administrative Supplement;Anatomy;Animal Model;Animals;Architecture;Astrocytoma;Award;Biological Models;Brain;Budgets;CD44 gene;CDKN2A gene;cell type;Clinical;clinically relevant;Convection;Data;Device or Instrument Development;Disease;effective therapy;Epidermal Growth Factor Receptor;Evolution;Exhibits;experience;Family suidae;Gene Expression;Gene Transfer;Genes;Genetic;Glioblastoma;Glioma;Gliomagenesis;Goals;Growth;Histologic;Human;Human Biology;human disease;human tissue;improved;interest;knock-down;Knowledge;lentivirally transduced;Lentivirus Vector;Lesion;life span;Malignant - descriptor;Miniature Swine;Modeling;Morbidity - disease rate;mortality;Mutation;Nature;Oncogenes;Operative Surgical Procedures;Outcome;parent project;Pathway interactions;patient population;PDGFB gene;Phenotype;PIK3CG gene;Platelet-Derived Growth Factor;porcine model;pre-clinical;Process;PTEN gene;Radiology Specialty;Rare Diseases;Refractory;Research Personnel;response;Risk;small hairpin RNA;Spinal Cord;standard of care;stem cell population;Structure;System;Therapeutic;therapeutic evaluation;therapeutic target;Tissue Model;TP53 gene;transcriptomics;Transgenes;tumor;tumor microenvironment;Tumor-associated macrophages;Universities;vector;Work

PROJECT_TITLE: Supplement: Lentiviral-Induced Swine Model of Spinal Cord Glioma - Tumor Microenvironment in IDH-Mutations Low-Grade Glioma


ORG_CITY: IOWA CITY

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Campylobacter spp. are the leading cause of bacterial-derived gastrointestinal infection in the world with significant impacts on human health in both developed and developing countries. This prevalence is primarily due to the ability of these bacteria to reside in the gastrointestinal tracts of various animals and transmit to humans where they colonize the colon and cause inflammation. This project will work to understand how a novel regulator in C. jejuni controls nutrient acquisition through sensing an uncommon intracellular signal and subsequently upregulating a system that can transport and metabolize a host-derived molecule to obtain the nutrient it contains.

PI_NAMEs: JOHNSON, JEREMIAH  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TITLE: Integration of nutrient availability, TCA cycle activity, and colonization factor expression in Campylobacter jejuni

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Clinical Research;Genetics;Health Services;Human Genome;Precision Medicine

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE The Precision Medicine Initiative Cohort Program will enroll one million volunteers into a national Biobank that broadly reflects the diversity of the U.S. population and help accelerate progress toward a new era of precision medicine on a larger scale than previously possible. The proposed Biobank will be a valuable resource of biological specimens and related health information from human volunteers that can then be used to address a wide range of scientific questions to improve public health. Mayo Clinic proposes to provide a state-of-the-art infrastructure and cost-effective services to ensure the success of the Precision Medicine Initiative Cohort Program.

PI_NAMEs: CEKANOVA, MARIA ;CICEK, MINE  (contact);MAGUIRE, ALANNA

PROGRAM_OFFICER_NAME: CAULDER, MARK

PROJECT_TERMS: Acceleration;Address;Advanced Malignant Neoplasm;arm;Automation;biobank;Biological;Blood;Businesses;Characteristics;Client;Clinic;Clinical;Clinical Services;cohort;Collection;Committee Members;Complex;cost;cost effective;Data;Disaster Planning;Disease;Elements;Enrollment;Ensure;Environment;epigenomics;Feces;Fee-for-Service Plans;genetic disorder diagnosis;Genome;Genomics;Goals;Health;health management;Healthcare Systems;hospital care;Human Volunteers;improved;Individual;individualized medicine;Information Management;Infrastructure;Institution;Intention;International;Label;Laboratories;Laboratory Research;Life Style;Link;Logistics;Management Information Systems;Medical;Medical Records;metabolomics;microbiome;multidisciplinary;Participant;Patient Care;Patients;PMI cohort;Population;precision medicine;Precision Medicine Initiative;Prevention strategy;Process;programs;Protocols documentation;Public Health;quality assurance;Questionnaires;Recovery;recruit;Regulation;Research;Research Personnel;Resources;response;Retrieval;Robotics;Route;Saliva;Sampling;scale up;Scientific Advances and Accomplishments;Secure;Services;Site;Specimen;Specimen Handling;square foot;success;System;Technology;Tissues;transcriptomics;Transportation;treatment strategy;United States;Urine;virtual;volunteer;Work

PROJECT_TITLE: Precision Medicine Initiative Cohort Program Biobank

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-K(51)R]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: SAN ANTONIO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: It is well established that complex mutations and genomic rearrangements are relevant to the development of human diseases, including cancer and many neurological and developmental syndromes. The proposed work will identify factors driving repair of double-strand DNA breaks (DSBs) into a maelstrom of destabilizing repair pathways and will unravel their molecular mechanisms. In addition, this research will define the patterns of genetic instabilities produced by deleterious DSB repair that are similar to those observed in association with human disease, which will contribute to ongoing data mining efforts to develop biomarkers for early detection and to design targeted therapies.

PI_NAMEs: MALKOVA, ANNA L (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Automobile Driving;Biological Assay;Cell Survival;cell type;Cells;chromosomal location;Chromosomes;Complex;Computer software;Congenital Abnormality;Cytidine Deaminase;Data;data mining;design;Detection;Development;digital;DNA biosynthesis;DNA Double Strand Break;DNA lesion;DNA Repair;DNA Repair Pathway;DNA Sequence Rearrangement;Double Strand Break Repair;early detection biomarkers;environmental stressor;Event;Genetic;Genome;genome sequencing;Genome Stability;Goals;high risk;HO nuclease;Human;human disease;innovation;Kinetics;Knowledge;Malignant Neoplasms;Mammals;Measures;Mediating;Meiosis;Methodology;Methods;Molecular;Monitor;Mutation;Names;Neurologic;Pathway interactions;Pattern;Positioning Attribute;programs;Proteins;RAD52 gene;Regulation;repaired;Research;Resolution;Role;Site;Syndrome;System;targeted treatment;tool;whole genome;Work;Yeasts

PROJECT_TITLE: Double strand break repair maelstrom: causes, mechanisms and genome destabilizing consequences

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Infectious Diseases;Maternal Health;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_DEPT: PEDIATRICS

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Undernutrition and infections are common in pregnancy in low-resource settings in the US and abroad. This project will rigorously study how iron and inflammation interact and affect the development of the human brain in utero. We aim to improve mechanistic understanding of how to optimally intervene during critical periods in pregnancy to improve the future neurodevelopmental potential of children worldwide.

PI_NAMEs: LEE, ANNE SHEE CC (contact)

PROGRAM_OFFICER_NAME: DEYAMPERT, TARA LYNN

PROJECT_TERMS: Accounting;Address;Adherence;Affect;Africa;Africa South of the Sahara;Age;Age Months;Animals;antenatal;Anthelmintics;arm;Behavior;Behavioral;Biological;Biological Availability;Biological Markers;Birth;Blood specimen;Brain;burden of illness;C-reactive protein;Cephalic;Child;Childhood;Cognitive;Complex;Counseling;critical period;Data;Development;Dose;early pregnancy;effective intervention;Effectiveness of Interventions;Electroencephalography;energy balance;Enrollment;Ethiopia;Ferritin;fetal;Folic Acid;follow-up;Fortification;Funding;Future;group intervention;Head circumference;helminth infection;Hemorrhage;hepcidin;high risk population;Homeostasis;Human;human fetal brain;improved;in utero;Individual;Infant;Infection;infection management;Infectious Pregnancy Complications;Inflammation;Inflammatory;Intake;Intention;Interleukin 6 Receptor;Interleukin-6;Intervention;intervention effect;iodized salt;Iron;iron deficiency;Iron deficiency anemia;Life;Malnutrition;Measures;Mediating;memory recognition;Metabolic;modifiable risk;Molecular;multimodality;Myelin;National Institute of Child Health and Human Development;neural;neural network;neurobehavior;Neurocognitive;neurodevelopment;Neurologic;neurotropic;Newborn Infant;Nutrient;nutrition;Nutritional;Nutritional Requirements;Nutritional Support;Observational Study;offspring;Orosomucoid;Outcome;Parents;Pathway interactions;Performance;Predisposition;Pregnancy;Pregnant Women;prenatal;Prenatal care;prenatal intervention;Prenatal Nutrition;primary outcome;processing speed;Proteins;psychologic;Randomized;Randomized, Controlled Trials;receptor;reproductive;Research;Resource-limited setting;Rest;Risk Factors;Role;Rural;secondary analysis;Serum;Structure;Subgroup;Supplementation;Testing;TFRC gene;Third Pregnancy Trimester;treatment arm;ultrasound;Umbilical Cord Blood;Underweight;Upper arm;Urinary tract infection;Variant;Ventricular;Visual evoked cortical potential;visual tracking;Vulnerable Populations;white matter;Woman;Work

PROJECT_TITLE: Nutrition and Inflammation in Pregnancy: Impacts on Early Human Brain Development

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Aging;Neurosciences;Sarcopenia

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative: Falls in the elderly most often result from frailty, which is caused by muscle weakness, impaired balance, and unstable walking. Studies in rodents have shown that age-induced changes that lead to frailty are preceded by structural and functional changes at the neurotransmitter release site within the neuromuscular junction. This proposal aims to utilize several new approaches to understand how aging alters neuromuscular synapses at an individual transmitter release site level.

PI_NAMEs: MERINEY, STEPHEN D (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Age;Aging;aging population;Calcium Channel;Computer Simulation;density;Elderly;Electrophysiology (science);equilibration disorder;Equilibrium;experience;falls;frailty;Future;Gait;Goals;imaging approach;Individual;Measurement;Motor;Motor Neurons;mouse model;muscle form;Muscle function;muscle strength;Muscle Weakness;Muscular Atrophy;neuromuscular;Neuromuscular Junction;neurotransmitter release;new therapeutic target;novel strategies;old mice;Optics;Population;presynaptic;recruit;reduced muscle strength;Rodent;sarcopenia;Site;superresolution imaging;Synapses;synaptic function;Testing;therapy development;Time;voltage;Walking

PROJECT_TITLE: Presynaptic active zone alterations that underlie dynapenia at aged mouse neuromuscular junctions


FUNDING_MECHANISM: OTHERS

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PI_NAMEs: VENTURA, ANDREA  (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: Actins;Acute;Adaptive Immune System;Address;Advocate;Affect;Architecture;ATAC-seq;Biology;Cancer cell line;cancer genomics;Cancer Patient;cancer type;Cell Line;Cells;Chemistry;ChIP-seq;Chromatin;Chromosome Pairing;Chromosomes;Circular DNA;Collaborations;combinatorial;Companions;computer scientist;Coordination and Collaboration;Coupled;Data Set;Development;DNA;Engineering;epigenomics;Event;Evolution;experience;experimental study;extrachromosomal DNA;Fostering;Funding Mechanisms;Gene Expression;Gene Order;Generations;Genes;Genetic Recombination;Genetic Transcription;Genetically Engineered Mouse;Genome;genome sequencing;Goals;Hi-C;Human;human cancer mouse model;Human Cell Line;Immune;Immune system;Immunobiology;in vivo;Individual;Induced Mutation;inducible Cre;Infrastructure;innovation;insight;Interferon Activation;International;Libraries;Licensing;machine learning algorithm;Malignant Neoplasms;mathematical model;MDM2 gene;Mediating;member;micronucleus;Modeling;Monitor;mouse model;Mouse Strains;Mus;Mutagenesis;Mutation;nanopore;neoplastic cell;novel;Oncogenes;Oncogenic;overexpression;Pathway interactions;Patients;Penetrance;Pharmaceutical Preparations;pharmacologic;Process;Productivity;programs;Reagent;recruit;Reporter;Reporting;Research Personnel;Resources;response;Role;Sampling;Series;single-cell RNA sequencing;Stimulator of Interferon Genes;Technology;Testing;Time;trait;transcriptome sequencing;Transgenes;tumor;tumor growth;tumor initiation;tumor microenvironment;tumor progression;Tumor Promotion;Tumor stage;tumorigenesis;Variant;whole genome;Work;yeast genetics

PROJECT_TITLE: eDyNAmiC (extrachromosomal DNA in Cancer) - Understanding the biology of ecDNA generation and action, and developing new ways to target these mechanisms in cancer


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: LEXINGTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative: The UK-REI-CC is an innovative coordinating center model centering collectivism and emphasizing the resilience of racial and ethnic marginalized communities. The UK-REI-CC will enhance and support the NIDA REI projects by providing resources for networking and training, conducting community- engaged research, data collection and analyses, and communication and dissemination. An administrative supplement is being requested to support unanticipated changes in personnel costs requiring multiple subawards.

PI_NAMEs: STEVENS-WATKINS, DANELLE J (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: Acceleration;Administrative Supplement;Affect;Black American;Collaborations;Color;Communication;Communities;community academic partnership;community engaged research;community engagement;Community Participation;community partners;Consultations;cost;dashboard;Data;Data Analyses;Data Collection;diversity and inclusion;Ensure;Ethnic Origin;Event;experience;Faculty;forgetting;Goals;healing;HIV;Hospitals;Human Resources;implementation science;Indigenous;Indigenous American;indigenous community;Inequity;innovation;Institution;Intervention;Justice;Kentucky;learning community;Limited English Proficiency;Maps;marginalized community;Measures;meetings;member;Modeling;National Institute of Drug Abuse;Needs Assessment;novel;online resource;overdose death;people of color;Pharmacology;Pharmacotherapy;Positioning Attribute;Press Releases;Publications;Qualifying;Race;Racial Equity;Randomized, Controlled Trials;recruit;Research;Research Personnel;Research Project Grants;resilience;Resource Sharing;Resources;retention rate;rural setting;Science;Series;Site;social media;structural determinants;substance use;Substance Use Disorder;synergism;System;tailored messaging;Testing;Training;Trauma;Universities;urban setting;Voice;webinar;Work

PROJECT_TITLE: The University of Kentucky Racial Equity Initiative Coordinating Center (UK-REI-CC)- Administrative Supplement


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE The objective of this supplement is to advance knowledge and build relationships to improve cancer-related outcomes for American Indian and Alaskan Native (AI/AN) populations. We will accomplish this by establishing and convening an initial meeting of an AI/AN Think Tank at Huntsman Cancer Institute, in Salt Lake City, Utah, with the goal of bringing key stakeholders and partners to the table for listening, discussion, and learning about the critical lack of medical options available to AI/AN populations and determination of potential solutions. This work will be driven by the AI/AN Tribal members, but fully supported and endorsed by 13 NCI-designated Cancer Centers, who have convened to form a consortium of Centers that are highly supportive of and engaged with AI/AN communities.

PI_NAMEs: ULRICH, CORNELIA M (contact)

PROGRAM_OFFICER_NAME: SHAFIK, HASNAA

PROJECT_TERMS: Address;Alaska Native;American Indian Population;American Indian Tribe;American Indians;Cancer Center;cancer survival;Cities;Communities;community intervention;Country;frontier;Goals;Health;Home;Idaho;improved;improved outcome;innovation;Intervention;Knowledge;Learning;Malignant Neoplasms;Medical;meetings;Montana;National Cancer Institute;Nevada;next generation;Outcome;Persons;Population;programs;Research;Research Personnel;Science;Sodium Chloride;Survival Rate;Training;tribal community;tribal member;tribal Nation;Tribes;United States;United States National Institutes of Health;Utah;Work;Wyoming

PROJECT_TITLE: American Indian/Alaskan Native Think Tank


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: KEY BISCAYNE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF MIAMI ROSENTEIL SCHOOL

ORG_STATE: FL

PHR: Aplysia are highly resistant to levels of hypoxia that would be lethal to humans or most other animals. The proposed program will fund a fellowship for a minority postdoctoral fellow to study how a particular type of cellular memory contributes to this ability and how this might inform mechanisms to increase the resistance of human brain cells to hypoxia.

PI_NAMEs: SCHMALE, MICHAEL C (contact)

PROGRAM_OFFICER_NAME: ZOU, SIGE

PROJECT_TERMS: Animals;Aplysia;Area;brain cell;career development;Development;DNA Methylation;Education;epigenetic marker;Epigenetic Process;experimental study;Exposure to;Fellowship;Funding;Future;Gene Expression;Health;Human;Hypoxia;Ischemia;Memory;Mentors;Minority;Modeling;Molecular;Nervous System;Neurodegenerative Disorders;neuroprotection;parent grant;Phenotype;Postdoctoral Fellow;programs;Reperfusion Injury;Research;Resistance;Resources;response;responsible research conduct;Role;Stress;Stroke;Training;transgenerational epigenetic inheritance;United States National Institutes of Health;Untranslated RNA

PROJECT_TITLE: NIH Aplysia Renewal Year 29 - 33


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Human Genome;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Narrative This is a multidisciplinary, highly collaborative consortium that combines next--generation sequencing with state- -of--the--art behavioral screening in a unique, genetically diverse, nonhuman animal model. The goals of this consortium are to identify gene variants that are associated with compulsive-like cocaine intake and behavioral endophenotypes using genome--wide association studies (GWAS) in behaviorally characterized heterogeneous stock rats, and to strengthen the infrastructure of a newly created data/tissue repository (Cocaine Biobank) accessible to all researchers to study the cellular and molecular mechanisms related to cocaine use disorder. Results from these studies have the potential to have a sustained and powerful impact on the field of addiction because they will identify novel druggable targets, provide a comprehensive analysis of cocaine addiction-like behaviors in males and females, and increase the impact of a unique data/tissue repository that will facilitate follow--up and replication studies.

PI_NAMEs: GEORGE, OLIVIER  (contact);PALMER, ABRAHAM A

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: addiction;Animal Model;aptamer;Behavior;Behavioral;biobank;Biological;Blood;Blood specimen;Brain;Chronic;Cocaine;Cocaine Dependence;cocaine self-administration;cocaine use;Cocaine use disorder;Code;cost;Data;DNA;Drug Kinetics;endophenotype;Ensure;Enzymes;esterase;Experimental Designs;experimental study;feasibility testing;Female;follow-up;Genes;Genetic;genetic variant;genome sequencing;genome wide association study;genomic locus;Goals;Implant;improved;in vivo;Individual Differences;Infrastructure;insight;Intake;Intravenous;Machine Learning;male;Measurement;Measures;Modeling;Molecular;multidisciplinary;new therapeutic target;next generation;next generation sequencing;novel;operation;parent grant;pre-clinical;Rattus;Research;Research Personnel;Resistance;Resources;screening;Self Administration;Structure of jugular vein;Tissue Banks;Tissues;Variant;Video Recording;Vulnerable Populations

PROJECT_TITLE: Identification of Genetic Variants that Contribute to Compulsive Cocaine Intakein Rats


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Postpartum hemorrhage occurs when the uterus bleeds excessively after childbirth and is often caused by failure of the uterus to contract properly. This study uses non-invasive genetic biomarkers to determine how well the uterus will respond to oxytocin, a common medication used during childbirth to help uterine contraction and treat hemorrhage. The biomarkers will allow us to develop new ways to predict risk for hemorrhage before birth and design treatments that are more effective, thereby saving mothers’ lives and minimizing long-term health problems.

PI_NAMEs: ERICKSON, ELISE N (contact)

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: Address;Administrative Supplement;Affect;Arizona;Binding;biobank;Biological Markers;Biosocial;Birth;Blood specimen;Blood Transfusion;Case/Control Studies;Cesarean section;Childbirth;Clinical;Clinical Assessment Tool;clinical biomarkers;clinical decision-making;clinical predictors;college;Complication;Contracts;Data;data repository;desensitization;Disadvantaged;Disparity;DNA;DNA Methylation;DNA Modification Process;dosage;Dose;Emergency Situation;Environment;epigenetic marker;Epigenetic Process;epigenetic regulation;epigenetic variation;Ethnic Population;experience;experimental study;Failure;Family;Gene Expression;Genes;Genetic;Genetic Markers;genetic testing;genetic variant;Genetic Variation;Genotype;Goals;Health;Hemorrhage;high risk;Hormones;Hour;improved;In Vitro;Individual;Induced Labor;Institute of Medicine (U.S.);Intervention;Investigation;Labor Onset;Learning;Life;Link;Location;Maternal Health;maternal morbidity;Maternal Mortality;Measurement;Measures;Medical;Medicine;Methods;Methylation;Mothers;Myography;Myometrial;myometrium;novel;Outcome;Oxytocin;Oxytocin Receptor;parent grant;Parents;Participant;Pattern;personalized intervention;Persons;Pharmaceutical Preparations;pharmacologic;Phenotype;Populations at Risk;Postpartum Hemorrhage;Postpartum Period;predictive tools;Pregnancy;prevent;Procedures;prospective;Prospective Studies;Publishing;racial disparity;racial population;receptor;receptor expression;Receptor Gene;Recording of previous events;recruit;Recurrence;Research;response;Risk;risk prediction;Role;Saliva;saliva sample;Salivary;Sample Size;Sampling;Science;Shapes;Social Environment;social health determinants;Specimen;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Surveys;Testing;therapy design;Tissues;United States;Update;uterine contractility;Uterine Contraction;Uterine hemorrhage;Uterine Inertia;Uterus;Variant;Western Blotting;women of color;Work

PROJECT_TITLE: Oxytocin sensitivity and postpartum hemorrhage: testing genetic and epigenetic biomarkers for improving maternal morbidity


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Recovery Support Services;Rehabilitation;Substance Misuse

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Opioid overdoses have increased for the last 20 years. Fortunately, there are evidence-based Medication Assisted Treatments for opioid use disorder (OUD). Unfortunately, fewer than 20% of individuals with OUD receive specialty treatment, and fewer receive optimal evidence-based treatment. It is clear that medication alone will not solve the current opioid epidemic; as a result, national organizations, such as SAMSHA, have emphasized the need for further development of a Recovery-Oriented Systems of Care. This NIDA R24 Project will develop a community-academic partnership to address the lack of evidence regarding recovery support services.

PI_NAMEs: UNICK, GEORGE JAY (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: Address;Administrator;Buprenorphine;care systems;Caring;Clinic;Collaborations;Communication;Communities;community academic partnership;community based care;community based service;cost;Coupled;data infrastructure;design;Development;doctoral student;effective therapy;efficacy study;Epidemic;evidence base;Evidence based treatment;experience;Faith-based organization;Family;Fertilization;Fostering;Funding;Health Services Accessibility;implementation research;implementation strategy;improved;Individual;Infrastructure;innovation;Institution;Insurance;Integrated Health Care Systems;interest;Intervention;Investments;Knowledge;Leadership;Learning;Measures;Medicaid;Medical;medical specialties;medication-assisted treatment;methadone treatment;Mission;National Institute of Drug Abuse;opioid epidemic;opioid misuse;opioid overdose;opioid use disorder;Outpatients;Overdose;overdose death;Patient-Focused Outcomes;Patients;payment;peer;peer recovery;peer support;Pharmaceutical Preparations;Pharmacological Treatment;Policy Maker;Practice based research;Privatization;programs;Provider;psychosocial;R24;Recommendation;Recovery;recovery services;Recovery Support;Reporting;Research;Research Design;Research Infrastructure;Research Methodology;Research Personnel;residence;Resources;Science;Series;Services;Societies;Substance Use Disorder;symposium;System;Testing;Training;treatment program;United States;webinar;Work

PROJECT_TITLE: Innovations in Recovery through Infrastructure Support (IRIS)


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: NOTRE DAME

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: 8. Project Narrative Alcohol use increases the risk for treatment dropout, relapse, and overdose in patients receiving opioid agonist treatment for opioid use. This project will develop and evaluate a modified alcohol-focused intervention tailored to address alcohol use in patients in opioid agonist treatment who are struggling with alcohol use disorder. This brief and scalable tailored intervention will have the potential to decrease alcohol use and improve opioid agonist treatment outcomes with minimal resources, adding in an innovative way to efforts to address the ongoing opioid overdose crisis in the United States.

PI_NAMEs: CARPENTER, RYAN W (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: acceptability and feasibility;addiction;Address;Alcohol abuse;Alcohol consumption;alcohol intervention;alcohol related problem;alcohol use disorder;Alcohols;Attention;Behavior Therapy;Buprenorphine;buprenorphine treatment;Clinic;Cognitive Therapy;cost;COVID-19 pandemic;Development;drinking;Dropout;effective therapy;Enrollment;Feedback;Focus Groups;follow-up;Goals;improved;Individual;individualized medicine;innovation;Intervention;intervention effect;Intervention Studies;Interview;Knowledge;Lead;Letters;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Modification;motivational enhancement therapy;Nurse Practitioners;Opioid;opioid agonist therapy;opioid epidemic;opioid overdose;opioid use;opioid use disorder;Outcome;Overdose;overdose risk;Participant;Patient Self-Report;Patients;peer support;Persons;Physicians;Population;Professional counselor;Protocols documentation;Provider;Public Health;Randomized;randomized, clinical trials;recruit;reduced alcohol use;Relapse;Reporting;Research;Research Personnel;Resources;Risk;Rural;Sampling;Specialist;Structure;suburb;theories;Therapeutic Intervention;therapy development;Time;Training;treatment as usual;Treatment outcome;treatment risk;United States;urban setting;Variant;Work

PROJECT_TITLE: Developing a modified brief alcohol-focused intervention tailored for patients with alcohol use disorder in opioid agonist treatment

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


NIH_SPENDING_CATS: Drug Abuse (NIDA only);HIV/AIDS;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: PROJECT NARRATIVE The United States faces significant challenges from drug overdoses and HIV, especially among populations involved in the criminal–legal system. A Justice HIV and Overdose Research Network will be established to address the intertwined crises of drug overdose and HIV within the U.S. criminal–legal system. The proposed Coordination Center at RTI International, termed the RTI EngageData Hub, aims to enhance the effectiveness of interventions through robust scientific coordination, data management, focused community engagement, and rigorous research dissemination.

PI_NAMEs: CANCE, JESSICA DUNCAN (contact)

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: Address;Administrative Coordination;archive data;Area;Collaborations;Common Data Element;Communication;Communication Methods;Communities;community engagement;Consultations;Data;data archive;data harmonization;data infrastructure;data integrity;data management;Data Management Resources;data sharing;Dedications;design;Development;digital platform;dissemination strategy;Drug user;economic determinant;economic evaluation;Economics;Effectiveness of Interventions;Ensure;Environment;experience;Face;Feedback;flexibility;Fostering;Harm Reduction;healing;Health;high risk population;HIV;HIV risk;improved;Individual;Infrastructure;innovation;Institution;interest;International;Justice;knowledge translation;Lead;Leadership;Legal system;Measures;meetings;Methodology;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;multidisciplinary;National Institute of Drug Abuse;novel;operation;Opioid;opioid epidemic;opioid overdose;Overdose;overdose risk;patient engagement;Patients;Persons;Pharmaceutical Preparations;Policies;Population;Positioning Attribute;Prevention;Principal Investigator;Process;public health intervention;Research;research data dissemination;Research Personnel;Research Project Grants;Resources;response;Services;social health determinants;Speed;Statistical Data Interpretation;Stream;Structure;Substance Use Disorder;support network;Syringes;Translating;translational framework;Translations;Trust;United States;United States National Institutes of Health;Update;web portal;Work;working group

PROJECT_TITLE: EngageData Hub: Collaborative Solutions for Justice, HIV, and Overdose


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Opioids;Pain Research;Substance Misuse

PHR: Narrative This is a multidisciplinary, highly collaborative consortium that combines next-generation sequencing with state-of-the-art behavioral screening in a unique, genetically diverse, nonhuman animal model. The goals of this consortium are to identify gene variants that are associated with oxycodone use, the effects of oxycodone on analgesia and pain using genome-wide association studies (GWAS), and the sensitivity to FDA-approved treatments in behaviorally characterized heterogeneous stock rats, and to maintain a data/tissue repository (Oxycodone BioBank) accessible to all researchers to study the cellular and molecular mechanisms of oxycodone addiction. Results from these studies have the potential to have a sustained and powerful impact on the field of addiction because they will identify novel druggable targets, provide a comprehensive analysis of oxycodone addiction-like behaviors in males and females, and maintain a unique data/tissue repository that will facilitate follow-up and replication studies.

PROJECT_TERMS: Absence of pain sensation;addiction;Affect;Analgesics;Animal Model;Behavior;Behavioral;biobank;Biological;Chronic;Computer software;computerized data processing;cost;Data;data curation;Data Set;Databases;Development;Ensure;Equipment;Failure;FDA approved;Female;follow-up;Genetic;genetic variant;genome sequencing;genome wide association study;Goals;high standard;Hyperalgesia;insight;Intake;Intervention;Intravenous;Maintenance;male;Manuals;Modeling;Molecular;multidisciplinary;new therapeutic target;next generation;next generation sequencing;novel;Oxycodone;oxycodone self-administration;Pain;pre-clinical;Process;Protocols documentation;Rattus;repaired;repository;Research;Research Personnel;Resources;Sampling;screening;Self Administration;Tissue Banks;Update;Validation;Withdrawal

PROJECT_TITLE: Use of Next-Gen Sequencing to Identify Genetic Variants that Influence compulsive Oxycodone Intake in Outbred Rats


NIH_SPENDING_CATS: Infectious Diseases

PHR: Project Narrative: Superoxide is a threat to all forms of life and its toxicity is harnessed by the immune system to combat infection. Superoxide dismutases are metal utilizing enzymes that enable us and invading microbes to cope with superoxide, yet we do not know the molecular or environmental factors that dictate the metal utilized by these enzymes. The proposed studies will address this unanswered question, providing insight into how both humans and invading pathogens overcome the universal threat of superoxide.

PI_NAMEs: KEHL-FIE, THOMAS EVERETT (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Amino Acid Sequence;Anaerobic Bacteria;Archaea;Bacteria;Bacteroides thetaiotaomicron;Binding;Biochemical;Biological Assay;Catalysis;Chemistry;cofactor;combat;coping;cystic fibrosis patients;Data Set;Development;Drug Metabolic Detoxication;Electron Spin Resonance Spectroscopy;Environment;Environmental Risk Factor;Enzymes;Eukaryota;Evolution;experimental study;Exposure to;Family;Family member;Genus staphylococcus;Goals;Growth;Human;Immune;Immune system;improved;In Vitro;Individual;Infection;insight;Invaded;Investigation;Iron;Leukocyte L1 Antigen Complex;Life;Manganese;member;Metagenomics;metalloenzyme;Metalloproteins;Metals;Microbe;Molecular;mutant;Organism;Oxidative Stress;Oxygen;pathogen;pathogenic microbe;Physiological;preference;Property;Protein Family;Proteins;Publishing;Reporting;Resistance;Respiratory Burst;Role;Shapes;SOD2 gene;soft drink;Staphylococcus aureus;Starvation;Streptococcus pneumoniae;Superoxide Dismutase;Superoxides;Testing;Time;tool;Toxic effect;Variant;Work

PROJECT_TITLE: Leveraging host-imposed metal starvation to elucidate the molecular and environmental factors that dictate metal utilization by the iron/manganese superoxide dismutase superfamily

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative: The proposed research aims to develop, translate, and validate innovative in-vivo imaging technologies to improve imaging and studying the development of the human fetal brain before birth. The technology will enable and improve studies on the development of the brain in fetuses with congenital disorders or fetuses at risk of having neurodevelopmental issues later in life. This in-turn is expected to result in timely and more effective treatments and therapeutic interventions that will lead to vastly improved patient outcomes in both the short- and long-term, effectively reducing the burden of human disabilities arising from congenital disorders.

PI_NAMEs: GHOLIPOUR-BABOLI, ALI  (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: 3-Dimensional;absorption;Acceleration;Affect;Algorithms;Anatomy;Birth;Brain;brain tissue;Cell Physiology;Cell Proliferation;Classification;Clinical Trials;Cognitive;cognitive disability;Compensation;Complex;Congenital Disorders;congenital heart abnormality;convolutional neural network;cost effective;Data;Data Set;deep learning;deep learning model;density;Development;disability;effective therapy;fetal;Fetal Development;Fetus;fetus at risk;Gestational Age;Head;Health Care Costs;High Prevalence;Human;Human Development;Hypoxia;Image;image processing;image reconstruction;Imaging technology;improved;in vivo;in vivo imaging;Injury;innovation;Investigation;large datasets;Life;Live Birth;Magnetic Resonance Imaging;Manuals;Measures;Mental Health;migration;Modeling;Morphologic artifacts;Mothers;Motion;Multicenter Studies;myelination;Nervous System Disorder;neurodevelopment;Neurodevelopmental Disorder;neuroimaging;Neurology;Neurons;Neurosciences;new technology;next generation;Noise;novel;Outcome;Patient-Focused Outcomes;Patients;Play;Positioning Attribute;prenatal;Process;Property;prospective;real-time images;Real-Time Systems;reconstruction;recurrent neural network;Relaxation;Reproducibility;Research;Resolution;Role;Rotation;Sampling;Scanning;Second Pregnancy Trimester;Signal Transduction;Site;Slice;Speed;success;System;Systems Integration;Techniques;Technology;Testing;Therapeutic Intervention;Time;Tissues;Training;Translating;Uterus;virtual

PROJECT_TITLE: Next-generation in-vivo fetal neuroimaging


NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Emergency Care;Physical Injury - Accidents and Adverse Effects

ORG_CITY: Moshi

ORG_COUNTRY: TANZANIA U REP

ORG_FIPS: TZ

ORG_NAME: KILIMANJARO CHRISTIAN MEDICAL CENTRE

PHR: Project Narrative Recent work shows that low middle income country trauma systems are limited by patient-payer models, limited personnel with specialized focus, high cost services, very limited access to care, and few specialists with adequate implementation research training to translate knowledge into practice to create and apply implementation science strategies. Optimizing care at each step along this continuum requires a rigorous, patient-centered, and health system–contextualized implementation research strategy and a network of like-minded, invested stakeholders. The objective of this supplement is to strengthen local capacity to train and supervise implementation science postdoctoral researchers and activities, by investing in the professional development of educators and collaborators at Kilimanjaro Christian Medical College and University, as well as expanding professional development activities.

PI_NAMEs: MMBAGA, BLANDINA THEOPHIL (contact);STATON, CATHERINE ANN

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Academic Medical Centers;Accounting;Address;Biometry;care systems;Caring;Collaborations;college;design;Epidemiology;Faculty;Goals;implementation research;implementation science;Injury;injury burden;injury-related death;Investments;low and middle-income countries;medical attention;Medical center;member;Mentors;Methods;Mind;Parents;Persons;post-doctoral training;programs;Research;SERPINI2 gene;Services;System;Tanzania;Training;Training Programs;trauma care;Trauma Research;Universities

PROJECT_TITLE: The TRECK Program Supplement: Trauma REsearch Capacity Building in Kilimanjaro, Tanzania Program Plan Supplement

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(50)-R]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Down Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric

PHR: Narrative Down Syndrome is primarily caused by trisomy of chromosome 21, resulting in an extra copy of over 200 genes and significant intellectual and developmental disability. Generating translational models and identifying the brain cell type specific contribution to Down Syndrome pathophysiology has been difficult and has hampered development and screening of new treatments. This project is relevant to the NIH’s mission to enhance life and reduce disability, aiming to understand how human microglia contribute to the neurodevelopmental pathogenesis of Down Syndrome with a goal of identifying novel treatment targets and screening methodologies.

PI_NAMEs: COUFAL, NICOLE GABRIELE (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Affect;Behavioral;Brain;brain cell;cell type;Cerebrum;Child;Chromosome 21;Coculture Techniques;Cognition;Complex;Data;Defect;Development;disability;Down's Syndrome;Drug Screening;Exhibits;Functional disorder;Gene Expression;Genes;Genetic;Genetic Transcription;genome-wide;Goals;Human;human model;Immune System Diseases;Impaired cognition;improved outcome;In Vitro;in vivo;Individual;innovation;Intellectual functioning disability;Knowledge;Life;Mental disorders;Methodology;Methods;Microglia;Mission;Modeling;Molecular;mouse model;Mus;Neurodegenerative Disorders;neurodevelopment;Neurodevelopmental Deficit;Neurons;neuropathology;new therapeutic target;novel;Organoids;Orthologous Gene;Pathogenesis;Pathology;Phenotype;pre-clinical;Regulation;screening;System;Testing;therapeutic target;translational model;Trisomy;United States;United States National Institutes of Health;Xenograft Model;young adult

PROJECT_TITLE: Microglial contribution to Down Syndrome Neuropathology

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Neurodegenerative;Neurosciences

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative  Developing disease-modifying therapies for neurodegenerative diseases is notoriously diﬃcult and is exacerbated by the lack of accurate statistical models to identify the optimal time for intervention. Here, we will use ﬁve longitudinal datasets of Huntington disease, a genetic neurodegenerative disease, to propose new statistical strategies to accurately estimate the disease course. These strategies can be used to help researchers identify when an experimental therapy could best modify the disease course and design a well-powered clinical trial to test that therapy.

PI_NAMEs: GARCIA, TANYA PAMELA (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Accreditation;Administrative Supplement;Alzheimer's Disease;Area;Award;Biological Markers;career development;clinical diagnosis;Clinical Trials;Clinical Trials Design;cohort;Computer software;Data;Data Set;design;Development;Diagnosis;Disease;Dropout;Funding;Future;Genetic;Huntington Disease;improved;innovation;Intervention;Investigational Therapies;Lead;longitudinal dataset;Measurement;Measures;Mentorship;model building;Modeling;Motor;Neurodegenerative Disorders;novel;open source;parent grant;Parkinson Disease;Patients;Postdoctoral Fellow;prevent;Productivity;Research Personnel;Risk;Science;Scientist;Source Code;Statistical Models;Symptoms;Testing;theories;Time;Training;United States National Institutes of Health;Validation;Visit;Work

PROJECT_TITLE: Landis Award for Outstanding Mentorship: Administrative Supplement to NS131225


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Food Allergies;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Pediatric;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Food allergy impacts 8% of children in the US but racial and ethnic differences in food allergy outcomes are not well understood. The FORWARD study is currently exploring racial and ethnic differences in clinical tolerance, development of new food allergies, food allergy management during adolescence, as well as food allergy phenotypes and endotypes. This supplement proposes to implement food allergy common data elements for data collection in FORWARD and build upon ongoing work to continue to develop a set of common data elements that can help provide consistency in food allergy data collection.

PI_NAMEs: GUPTA, RUCHI S (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Adolescence;Affect;Age;Allergic;Asian population;Asthma;Award;Black race;Child;Clinical;clinical development;Common Data Element;comorbidity;Data;Data Collection;data integration;Development;Documentation;Eczema;electronic data;Ensure;ethnic difference;experience;Family;Food;Food Hypersensitivity;Goals;health care service utilization;Hispanic;Immune Tolerance;Impairment;Individual;Life;Manuals;middle childhood;Observational Study;Outcome;Parents;Patients;Phenotype;Practice Management;Prevalence;Privatization;prospective;psychosocial outcome;racial difference;response;Severities;Site;Standardization;Structure;Surveys;United States;Variant;Work

PROJECT_TITLE: FORWARD Common Data Elements Supplement (CDE)


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: NARRATIVE The proposed project is relevant to public health and to the NIH because it seeks to use public health and clinical data on opioid use disorders (OUD) outcomes for mothers and infants, which is the leading cause of death to mothers one year after deliver and can lead to neonatal withdrawal syndrome (NOWS) and other poor outcomes. Insufficient or incomplete data about OUD and lack of integrated programs for OUD treatment during pregnancy can be barriers to providing optimal care to mothers and infants. Completion of this project is a first step toward creating a data dashboard development methodology that can inform continuous prenatal, maternal, and infant care in other communities.

PI_NAMEs: MARSHALL, JENNIFER  (contact);WRIGHT, TANNER

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: Address;Affect;Age;Agreement;Appointment;Area;behavioral health;Buprenorphine;care coordination;Caring;case finding;Cause of Death;Child;Child Mortality;Child Welfare;Childhood;Clinic;Clinical;clinical care;Clinical Data;clinically relevant;Code;Communication;Communities;Community Healthcare;Consolidated Framework for Implementation Research;cost;Cost Analysis;County;dashboard;Data;Data Aggregation;Data Collection;data dashboard;data integration;Databases;Development;Diagnostic;Discipline of obstetrics;Early Intervention;efficacy study;Equity;Ethnic Origin;Evaluation;Family;Florida;Frequencies;Funding;gaps in access;General Hospitals;Geography;Goals;Grant;Harm Reduction;Health;health data;health inequalities;Health Services Accessibility;Health system;Healthcare;high risk;Home;Hospitals;implementation cost;implementation evaluation;improved;improved outcome;Individual;Infant;Infant Care;infant outcome;Infrastructure;innovation;integrated care;Internal Medicine;Intervention;intervention program;Lead;Live Birth;Location;Maintenance;Maternal Mortality;maternal opioid use;maternal outcome;Measures;medication for opioid use disorder;Medicine;Methadone;Methodology;Methods;Modeling;Morbidity - disease rate;Mothers;National Institute of Drug Abuse;Neonatal;Neonatal Abstinence Syndrome;neonatal outcome;neonate;Opioid;opioid exposure;opioid use;opioid use disorder;Outcome;Outcome Measure;overdose prevention;Parents;Patient-Focused Outcomes;Patients;Pediatrics;peer support;personalized approach;pharmacologic;Pharmacological Treatment;Population;post intervention;post pregnancy;Postpartum Period;Pregnancy;Pregnancy Outcome;prenatal;Prenatal care;Prevention strategy;primary outcome;Process;program costs;programs;Provider;Public Health;Publishing;Quality of Care;Race;racial disparity;Recovery;Recovery Support;Registries;Research;Resources;Services;Site;social health determinants;societal costs;standard care;Standardization;Stream;Substance Use Disorder;System;Telephone;Testing;Thinking;Time;Transportation;United States National Institutes of Health;Universities;Woman

PROJECT_TITLE: CADENCE - Continuous And Data-drivEN CarE


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Endometrial cancer is more common than all other gynecologic cancers combined, and the incidence and death rates have both increased over the past 25 years. The work proposed will lead to both an improved understanding of endometrial cancer biology and new approaches to prevent and treat this disease. Additionally, this SPORE will expand the numbers of researchers dedicated to studying endometrial cancer.

PI_NAMEs: BENBROOK, DORIS MANGIARACINA;LESLIE, KIMBERLY K.;MUTCH, DAVID G (contact)

PROGRAM_OFFICER_NAME: BASA JANAKIRAM, NAVEENA

PROJECT_TERMS: Address;Affect;Aftercare;angiogenesis;anti-cancer research;Atypical Endometrial Hyperplasias;axl receptor tyrosine kinase;behavior test;biobank;Bioinformatics;Biological;Biological Process;biomarker identification;Biometry;Biopsy;Body Weight decreased;Cancer Biology;Cancer Model;Cancer Patient;Cancer Science;cancer therapy;career;Clinical;clinical practice;Clinical Trials;Collaborations;Combination Drug Therapy;Communities;Complement;Data;Data Analyses;Death Rate;Dedications;design;Development;Disease;drug development;Drug Kinetics;Early Diagnosis;early phase clinical trial;effective therapy;Endometrial Carcinoma;Endometrial Hyperplasia;Enrollment;Ensure;Equity;Fertility;fluorescence imaging;forging;Fostering;Funding;Future;Genes;Goals;Health Sciences;Heat shock proteins;Histology;Immunohistochemistry;Immunologics;improved;Incidence;Individual;inhibitor;innovation;Institution;interest;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of ovary;Malignant Neoplasms;Marriage;Measures;member;Mentors;Metabolic;metabolomics;Minority;Molecular;Molecular Chaperones;molecular marker;Mutation;New Mexico;novel;novel drug combination;novel marker;novel strategies;novel therapeutics;Obesity;Oklahoma;Pathologic;Pathology;Patient-Focused Outcomes;Patients;Population Sciences;pre-clinical;Premenopause;preservation;prevent;Prevention;Prevention strategy;Primary Prevention;Progestins;programs;Proteins;recruit;Recurrence;Research;Research Personnel;Research Priority;Research Project Grants;Research Support;Resources;response;response biomarker;Route;Scientist;Specialized Program of Research Excellence;Specimen;stable isotope;Standardization;Testing;Therapeutic;therapy outcome;TP53 gene;Translational Research;translational research program;translational study;treatment response;treatment strategy;Tumor Biology;Underrepresented Minority;Underrepresented Populations;United States;Universities;Uterus;virtual;Washington;Woman;Work

PROJECT_TITLE: Route 66 Endometrial Cancer SPORE


ORG_CITY: SAN DIEGO

ORG_NAME: SCINTILLON INSTITUTE FOR PHOTOBIOLOGY

PHR: Project Narrative This research will test the potential to repurpose a small molecule BRAF kinase inhibitor, dabrafenib, an FDA- approved drug for several cancers, for new use in preventing cisplatin- induced hearing loss. Significant protection against cisplatin-induced hearing loss has been achieved with oral delivery of dabrafenib in mouse models in doses approved in humans. The successful completion of this study will provide the crucial data needed for rapidly advancing dabrafenib to clinical studies in humans for prevention of hearing loss.

PI_NAMEs: TEITZ, TAL  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Affect;Aging;Anti-Inflammatory Agents;Antibiotic Therapy;Antioxidants;Auditory;Benchmarking;Biological;Biological Assay;Biological Availability;Biological Markers;BRAF gene;Cancer Patient;cancer therapy;Cell Death;Cell Death Induction;Cell Line;Cell Physiology;Cells;Cessation of life;chemotherapy;Cisplatin;cisplatin induced hearing loss;Clinic;Clinical;Clinical Research;Clinical Trials;Cochlea;conditional knockout;Data;Dexamethasone;Dose;drug repurposing;ebselen;effectiveness testing;experimental study;FDA approved;Genetic;Goals;Hair Cells;hearing impairment;high throughput screening;Human;in vivo;inhibitor;Inner Supporting Cell;kinase inhibitor;Knockout Mice;Labyrinth;lateral line;Lethal Dose 50;Malignant neoplasm of lung;Malignant Neoplasms;MAP2K1 gene;MAPK3 gene;Medical;Melanoma;Methionine;Modeling;Molecular;Molecular Target;Morphology;mouse model;Mus;Neuroblastoma;neuromast;Noise;noise exposure;Noise-Induced Hearing Loss;Non-Small-Cell Lung Carcinoma;Oral;otoprotectant;ototoxicity;Outer Hair Cells;Pathway interactions;Patients;Performance;Persons;Phalanx;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phosphorylation;postnatal;pre-clinical;prevent;prevent hearing loss;Prevention;Property;Protein Kinase;Proto-Oncogene Proteins B-raf;Protocols documentation;Publishing;Raf Kinase Inhibitor;Regimen;Research;Resistance;Role;Route;Signal Transduction;small cell lung carcinoma;small molecule;small molecule inhibitor;sodium thiosulfate;standard care;standard of care;Stress;Supporting Cell;Testing;Therapeutic;Therapeutic Index;therapeutic target;Time;Toxic effect;Translations;tumor;Tumor Cell Line;Up-Regulation;Work;Zebrafish

PROJECT_TITLE: Repurposing an FDA approved Drug, B-Raf Kinase Inhibitor Dabrafenib for Protection from Cisplatin- and Noise- induced Hearing Loss


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Infant Mortality;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Several registries exist across different study networks. Using existing maternal and neonatal registries to identify common data elements with the same definitions will improve collection of information on mothers and babies in future studies.

PI_NAMEs: CLIFTON, REBECCA GERSNOVIEZ (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Administrative Supplement;Admission activity;antenatal;clinical center;Clinical Research;Clinical Trials;cohort;Collaborations;Collection;Common Data Element;Counseling;Data;Data Collection;Data Coordinating Center;Dedications;Ensure;experience;Funding;Future;high risk;Hospitalization;Hospitals;improved;Incidence;Infant;Link;Maternal-Fetal Medicine Units Network;Medical Records;Mothers;Multicenter Neonatal Research Network;National Institute of Child Health and Human Development;Neonatal;neonatal outcome;Observational Study;Outcome;Parents;Perinatal;periviable;Persons;Pregnancy;pregnant;Principal Investigator;Registries;Research;Research Infrastructure;Sample Size;screening;stillbirth

PROJECT_TITLE: Maternal-Neonatal Registry (PAIR) Supplemental Funding


NIH_SPENDING_CATS: Aging;Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Kidney Disease;Liver Cancer;Liver Disease;Nutrition;Obesity;Orphan Drug;Rare Diseases

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: Project Narrative: There are no approved therapies for Non-alcoholic steatohepatitis (NASH), the most severe form of fatty liver disease that affect approximately 20% of the global population and predisposes them to liver cancer, chronic kidney disease (CKD) and cardiovascular diseases (CVD). The project is relevant to NIH’s mission because it will focus on translating a novel target for the prevention and cure of NASH/HCC and CKD with the goal of improving CVD and overall survival. Specifically, the proposed study will establish the pre-clinical validation of anti-sense oligo (ASO) mediated suppression of Ubiquitin D (UBD) as a potential therapeutic approach for NASH/HCC and CKD.

PI_NAMEs: DHAR, DEBANJAN  (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: 3-Dimensional;Academia;Address;Adipose tissue;Affect;Antisense Oligonucleotides;Brain;Cardiac Myocytes;Cardiovascular Diseases;cardiovascular disorder risk;Cell Culture Techniques;Cells;Central obesity;Chronic Kidney Failure;chronic liver disease;chronic liver inflammation;Cirrhosis;Clinic;Collaborations;Collagen;comorbidity;Complex;Data;Deposition;Development;Diabetes Mellitus;Diet;Disease;Disease Outcome;disease phenotype;Disease Progression;efficacy evaluation;extend lifespan;fatty liver disease;Fibrosis;Foundations;Functional disorder;Future;Gene Expression;Genes;Goals;Health;Health Care Costs;Hepatic;hepatocellular carcinoma cell line;Hepatocyte;high risk;Human;human disease;Hyperphagia;Immune system;improved;Industry;Inflammation;Insulin Resistance;Kidney;Kidney Diseases;kidney fibrosis;life span;lifestyle intervention;Link;Liver;liver injury;liver transplantation;Malignant neoplasm of liver;Mediating;member;Metabolic;Metabolic syndrome;microbiome;Mission;Modeling;mortality;mortality risk;mouse model;Mus;Mutation;MXI1 gene;new therapeutic target;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;novel;novel therapeutics;Obesity;Operative Surgical Procedures;Organ;Pathway interactions;Patients;Pharmacologic Substance;Phenotype;Play;Population;pre-clinical;Pre-Clinical Model;prevent;Prevention;Primary carcinoma of the liver cells;protein aggregation;Protein Family;Proteins;Proteinuria;Reporting;Risk;Role;Severities;side effect;Signal Transduction;spheroids;System;targeted agent;targeted treatment;Testing;Therapeutic;therapeutic evaluation;therapeutic target;TP53 gene;Translating;translational study;Treatment Efficacy;tumor;tumor xenograft;UBD protein;Ubiquitin Like Proteins;Ubiquitination;United States National Institutes of Health;Validation;western diet;Xenograft Model

PROJECT_TITLE: Ubiquitin D as a potential therapeutic target for NASH, HCC and chronic kidney diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-H(55)R]


NIH_SPENDING_CATS: Chronic Pain;Genetics;Human Genome;Pain Research

PHR: Narrative The goal of the Acute to Chronic Pain Signatures (A2CPS) program is to identify biomarkers and their collective biosignatures that predict susceptibility or resilience to the development of chronic pain after an acute pain event. In this administrative supplement, the UC San Diego Omics Data Generation Center (ODGC) will use white blood cells (WBCs) from buffy coat samples collected by the A2CPS to determine single nucleus gene expression signatures associated with the development of chronic pain. This project is relevant to public health because it will aid in our understanding of the role of immune cells in chronic pain and complement biosignatures developed by the parent grant.

PI_NAMEs: FISCH, KATHLEEN MARIE;JEPSEN, KRISTEN LYNN;LAURENT, LOUISE CHANG (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Acute;Acute Pain;Administrative Supplement;biomarker identification;biosignature;Cell Nucleus;Cells;Characteristics;chronic pain;Complement;Data;Development;Event;experimental study;feasibility testing;Gene Expression;Gene Expression Profile;Generations;Goals;Immune;Individual;knee replacement arthroplasty;Leukocytes;Operative Surgical Procedures;parent grant;Population;Postoperative Pain;Predisposition;programs;Public Health;resilience;Role;Sampling;single-cell RNA sequencing;transcriptome

PROJECT_TITLE: Administrative Supplement to U54 DA049115: Exploring Immune Transcriptome Signatures in the Development of Chronic Pain