NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dystonia;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: AMHERST

ORG_DEPT: NEUROLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Narrative: Genetic mutations in ATP1A3 present with an extraordinarily wide range of symptoms, which is an obstacle to both diagnosis and the development of treatments. We are making two major shifts, one to use an unbiased gene-first approach to the discovery of ATP1A3 clinical consequences, and the other to move toward mechanism-based treatments. A shift towards telemedicine will broaden our reach; partnerships with databases that encompass gene and clinical records will give access to information on patients with or without diagnoses; and laboratory studies will investigate mechanisms of treating mutation damage with a pharmacological approach.

PI_NAMEs: BRASHEAR, ALLISON  (contact)

PROJECT_TERMS: Acceleration;Access to Information;Adult;afferent nerve;Anatomy;Apoptosis;ATP1A3 gene;Atrophic;autism spectrum disorder;Biochemical;Blood flow;blood oxygenation level dependent imaging;Brain;candidate identification;Cardiac;causal variant;Cell Line;Cells;Clinical;Clinical Data;Clinical Trials;Code;Cognitive;Consensus;Cytoplasm;Data;Data Analyses;Data Set;Databases;Diagnosis;diagnostic tool;disabling disease;Disease;DNA Sequence Alteration;drug efficacy;Dystonia;Dystonia 12;Electronic Health Record;Epilepsy;Evaluation;FDA approved;Functional disorder;functional restoration;Future;Gait;Gene therapy trial;Genes;Genetic;Genotype;Goals;heart rhythm;Heat-Shock Response;Heterozygote;Impairment;improved;Individual;infancy;Intake;interdisciplinary approach;Ion Transport;Knowledge;Laboratories;Laboratory Study;Link;Magnetic Resonance Imaging;Measures;Mental disorders;Metabolism;Missense Mutation;Molecular;molecular sequence database;Motor;mutant;Mutation;Natural History;Nervous System Disorder;Neurologic;Neurons;novel;novel diagnostics;Parkinsonian Disorders;Pathogenicity;Patient Selection;patient subsets;Patients;Peripheral Nerves;Pharmaceutical Preparations;pharmacologic;Phenotype;phenotypic data;Play;Population;pre-clinical;protein function;protein misfolding;Proteins;psychologic;Publishing;Pump;Quality of life;Records;recruit;response;Risk;Risk Factors;risk variant;Role;Sampling;Severities;Speech;Structure;symptom cluster;Symptoms;Syndrome;Telemedicine;Temperature;Testing;therapy design;therapy development;Time;trafficking;treatment trial;Variant;Work;Youth

PROJECT_TITLE: CLINICAL, GENETIC, AND CELLULAR CONSEQUENCES OF MUTATIONS IN NA,K-ATPASE ATP1A3

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Mental Health;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Radiation Oncology;Rare Diseases;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: ROCHESTER

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Memantine is a drug used for adult dementia patients that has been shown to decrease the changes in thinking and memory that occur after whole brain radiotherapy in adults with brain metastasis. Based on the mechanism of action and animal models we expect memantine will be effective and safe for reducing short and long-term changes in brain function for children receiving radiation for brain tumors. Reduction of specific brain volumes after radiotherapy are associated with memory and thinking changes and we also hypothesize that neuroprotection with memantine will result in a reduction in volume loss in critical regions of the brain.

PI_NAMEs: LAACK, NADIA N (contact)

PROGRAM_OFFICER_NAME: GOOD, MARGE

PROJECT_TERMS: Acceleration;Adult;Adverse effects;Affect;Affinity;Age;Alzheimer's Disease;Amino Acid Neurotransmitters;Animal Model;antagonist;Attention;Behavioral;Biological Markers;Brain;Brain imaging;Brain Neoplasms;Brain region;brain volume;Cell Line;Central Nervous System Neoplasms;Cephalic;Child;Childhood;Childhood Brain Neoplasm;Clinical Trials;Cognition;Cognitive;cognitive function;cognitive testing;Combined Modality Therapy;Complex;Complication;computerized;Cranial Irradiation;curative treatments;Data;Dementia;Development;Dose;dosimetry;Drug usage;Education;effective therapy;efficacy evaluation;efficacy study;emotional distress;Employment;Evaluation;Excitatory Amino Acids;excitotoxicity;executive function;frontal lobe;Functional disorder;Future;Glutamates;Health;Hippocampus;imaging biomarker;Impaired cognition;Impairment;improved;in vivo;Incidence;Injury;Intervention;Ischemia;Learning;Long-Term Potentiation;Magnetic Resonance Imaging;Maintenance;Marriage;Measurement;Measures;Memantine;Memory;Metastatic malignant neoplasm to brain;Methods;Microvascular Dysfunction;Modeling;Morbidity - disease rate;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;Neonatal;Neurodegenerative Disorders;Neuronal Injury;Neurons;neuroprotection;Neuroprotective Agents;Neuropsychology;NMDA receptor antagonist;novel;Oral;Outcome;Participant;Pathologic;Patients;Pediatric Neoplasm;Pediatric Oncology Group;pediatric patients;Phase;phase III trial;Physiological;Placebo Control;Placebos;Population;pre-clinical;Pre-Clinical Model;preservation;prevent;Primary Brain Neoplasms;processing speed;protective effect;Radiation;Radiation Injuries;Radiation therapy;radiation-induced injury;radiological imaging;Randomized;Rattus;receptor;Research Design;Research Personnel;Research Priority;Risk;Role;Severities;Social Adjustment;Structure;Supratentorial Brain;Survivors;survivorship;Testing;Therapeutic Effect;Thinking;Time;tool;Toxic effect;Vascular Dementia;white matter;young adult

PROJECT_TITLE: Utility of memantine in preventing cognitive dysfunction in children receiving cranial radiotherapy


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Asthma;Biotechnology;Genetics;Lung

ORG_CITY: ANN ARBOR

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The proposed research is relevant to public health because elucidation of posttranscriptional control mechanisms is ultimately expected to increase understanding of allergic airway inflammation in asthma which is relevant to the part of the NIH’s mission to increase knowledge that will help t-+-*o reduce morbidity in asthma.

PI_NAMEs: ATASOY, ULUS  (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: 3' Untranslated Regions;adaptive immunity;Affect;airway inflammation;Allergens;allergic airway inflammation;Asthma;asthmatic;asthmatic airway;Binding;CD4 Positive T Lymphocytes;Characteristics;Competitive Binding;cytokine;Cytokine Gene;Data;Disease;economic cost;Elements;Equilibrium;Family member;GATA3 gene;Gene Expression;Genes;Genetic Transcription;genome-wide;Goals;Human;HuR protein;Immune;Immunity;Inflammation;Inflammatory;Knowledge;Mediating;messenger ribonucleoprotein;Messenger RNA;MicroRNAs;Mission;Modeling;Molecular;Morbidity - disease rate;mouse model;mRNA Expression;mRNA Stability;Mus;Network-based;novel;novel therapeutics;Outcome;overexpression;Ovum;Play;Population;Post-Transcriptional Regulation;posttranscriptional;Production;Proteins;Public Health;Publishing;Pulmonary Inflammation;Regulation;Research;Research Personnel;Ribonucleoproteins;RNA-Binding Proteins;Role;symptom treatment;System;T-Lymphocyte;Testing;TIS11 protein;transcriptomics;Translations;United States National Institutes of Health;Work;ZFP36L2 gene

PROJECT_TITLE: Mechanisms of HuR Overexpression in Asthmatic Endotypes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-K(57)]


ADMINISTERING_IC: GM

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SEATTLE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: This project studies the interaction with RNA and activity of a class of small molecules that feature the pharmaceutical properties of successful drugs. Their development into drug candidates with validated cellular activity would open up a large reservoir of untapped targets to treat human disease, but success requires a fundamental chemical and biophysical understanding of how these molecules bind to RNA so potently. This project will pursue fundamental studies of molecular recognition of RNA by drug-like small molecules and utilize this knowledge to discover new inhibitors of replication of the highly pathogenic Dengue and Zika viruses.

PI_NAMEs: VARANI, GABRIELE  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Address;Affinity;Binding;Biophysics;Cells;Chemicals;Chemistry;Clinical;Collaborations;Communicable Diseases;Dengue Infection;Dengue Virus;Development;drug candidate;drug-like compound;experimental study;Goals;human disease;inhibitor;Investigation;Knowledge;Legal patent;Licensing;Literature;Medicine;Messenger RNA;model organism;molecular recognition;nanomolar;Oncology;Pathogenicity;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Property;Publications;RNA;RNA Viruses;scaffold;small molecule;Small RNA;Specificity;Structure;success;Thermodynamics;three dimensional structure;Vaccination;Viral Physiology;Zika Virus

PROJECT_TITLE: ncRNA: structure, function and inhibition

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PHR: PROJECT NARRATIVE TDP-43 is known to be critical to the pathogenesis of frontotemporal lobar degeneration (FTLD) but now has also become an important player in the Alzheimer's disease neurodegenerative process. We have been studying TDP-43 in FTLD and in Alzheimer's disease for over a decade and have made significant discoveries that have contributed to better understanding and recent awareness of the importance of TDP-43 beyond FTLD. In this 3rd cycle we will expand upon our recent discoveries that there are two different types of TDP-43 deposition in Alzheimer's disease and that different molecular specie of TDP-43 are associated with different inclusions in FTLD, as well as develop a biomarker using [18F]-fluorodeoxyglucose PET scan to help predict the presence of TDP-43 in Alzheimer's disease.

PI_NAMEs: JOSEPHS, KEITH A (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;Alzheimer's disease therapy;Amyloid beta-Protein;Attention;Autopsy;Awareness;Biological Markers;Blood Vessels;Brain;C-terminal;cerebral atrophy;Cessation of life;cohort;Data;Deposition;Development;Diagnosis;Diagnostic;Disease;DNA-Binding Proteins;fluorodeoxyglucose positron emission tomography;Frontotemporal Lobar Degenerations;Genetic;Goals;Head;Heterogeneity;hippocampal atrophy;Hippocampus;improved;individual patient;International;Knowledge;Length;Life;Ligands;link protein;Magnetic Resonance Imaging;Manuscripts;Measures;medial temporal lobe;Modeling;Molecular;Morphology;MRI Scans;Neocortex;neocortical;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroimaging;neuropathology;novel;Pathogenesis;Pathologic;Patients;Peer Review;Performance;Phosphorylation;Play;Positron-Emission Tomography;predictive modeling;Process;Prognosis;protein TDP-43;Proteins;Publications;risk variant;Role;Scanning;System;targeted treatment;tau Proteins;Testing;therapeutic target;Time;Variant;Work

PROJECT_TITLE: Understanding the role of TDP-43 in Alzheimer’s disease and FTLD


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Digestive Diseases;Genetics;Infectious Diseases;Prevention;Rare Diseases;Stomach Cancer

ORG_CITY: TUSKEGEE INSTITUTE

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: TUSKEGEE UNIVERSITY

ORG_STATE: AL

PHR: Narrative Communication between cells of gastric epithelial glands and surrounding stromal cells is indispensable for normal stomach function and misregulation of the signaling networks executing this communication can cause inflammation and precancerous lesions that can become cancerous. Helicobacter. pylori infection, the highest risk factor for gastric cancer, disrupts signals originating from stromal cells that maintain normal growth and function of epithelial glands and prevent inflammation. The current proposal will define how misregulation of protein kinase A (PKA) signaling causes inflammation and precancerous lesions via disrupting stromal-epithelial communication.

PI_NAMEs: PURI, PAWAN  (contact)

PROGRAM_OFFICER_NAME: RICHARDS, CRYSTAL LYNETTE

PROJECT_TERMS: Adenocarcinoma;Alleles;American Society of Clinical Oncology;antagonist;Anti-Inflammatory Agents;Antibiotic Therapy;Atrophic;Atrophic Gastritis;Automobile Driving;Biomedical Research;Bone Morphogenetic Proteins;Cancer Etiology;Cancerous;Cause of Death;Cells;Cessation of life;Chronic;Communication;conditional mutant;constitutive expression;Cyclic AMP-Dependent Protein Kinases;cytokine;Data;Down-Regulation;effective therapy;Epithelial-Stromal Communication;Epithelium;experimental study;Gastric Adenocarcinoma;gastric carcinogenesis;gastric intestinal metaplasia;Gastric Parietal Cells;gastric pre-neoplasia;Gastritis;Genetic;Gland;Growth;Helicobacter;Helicobacter felis;Helicobacter Infections;Helicobacter pylori;high risk;Homeostasis;Hyperplasia;Incidence;Infection;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Infiltrate;inflammatory milieu;Inflammatory Response;inhibitor;Intestinal Intraepithelial Neoplasia;Lesion;Ligands;malignant stomach neoplasm;Mediating;Mesenchymal;Mesenchyme;Messenger RNA;Metaplasia;minority student;Modeling;Molecular;Mucous body substance;Mucous Membrane;Mus;Mutant Strains Mice;Neoplasms;neoplastic;novel;Outcome;overexpression;Pathologic;Pathology;Pathway interactions;Patients;Phosphorylation;Predisposition;premalignant;Preneoplastic Conditions;prevent;Prevention strategy;Proliferating;promoter;Proteins;Research;Risk;Risk Factors;Role;Series;Severities;Signal Transduction;Signaling Protein;spasmolytic polypeptide;STAT3 gene;Stimulus;Stomach;Stromal Cells;Students;synergism;Testing;Tissues;Training;Transgenic Mice;Transgenic Organisms;treatment strategy;tumor;Universities;Up-Regulation

PROJECT_TITLE: Role of Protein Kinase A (PKA)-mediated mesenchymal-epithelial crosstalk in gastric preneoplasia


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Infectious Diseases;Neurodegenerative;Neurosciences;Palliative Care;Prevention

ORG_CITY: STANFORD

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative The human cathelicidin peptide LL-37 is unique in our proteome, and is central to innate immunity as an antibacterial and antiviral defense molecule released from immune and epithelial cells. Based on Dr. Barron’s discovery that LL-37 binds the Alzheimer’s-associated peptide Ab, forming a stable nontoxic complex, halting Ab fibril formation, and abolishing Ab cytotoxicity to neurons, this project will determine whether chronic, oral P. gingivalis infection sets the stage for dementia via degradation of LL-37, and a subsequent crippling of the brain’s immune defense and regeneration mechanisms. In vivo studies will explore this novel innate immune etiology and mechanism for sporadic Alzheimer’s dementia, and test whether disease is prevented by early-life upregulation of LL-37 to disallow establishment of infections. !

PI_NAMEs: BARRON, ANNELISE EMILY (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Adopted;Agonist;Alzheimer's Disease;Anti-Bacterial Agents;antimicrobial;B-Lymphocytes;Binding;Brain;brain tissue;Butyrates;cathelicidin;cathelicidin antimicrobial peptide;Cells;Cholecalciferol;Chronic;Clinical Trials;Cognition;Complex;cytotoxicity;Dementia;Disease;Economics;Epithelial Cells;Epithelium;Etiology;Exercise;Funding;Health;Herpesviridae;Herpesviridae Infections;Host Defense;Human;Immune;improved;in vivo;Infection;Infection prevention;insight;Knockout Mice;Knowledge;Life;Macrophage;Microglia;Mus;Natural Immunity;Natural Killer Cells;Natural regeneration;Nerve Degeneration;Neurons;neutrophil;novel;novel therapeutics;Oral;pathogen;pathogenic bacteria;pathogenic virus;Peptides;Pharmaceutical Preparations;Porphyromonas gingivalis;Prevalence;prevent;Process;Production;Proteome;Research Personnel;Risk;Role;RXR;Structure;symptom management;Testing;United States National Institutes of Health;Up-Regulation;Vaccines;Viral;Virulence Factors;wound

PROJECT_TITLE: Role of Innate Immune Dysregulation in the Etiology of Dementia


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;HIV/AIDS;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE Complex clinical questions in neuroHIV require interdisciplinary and translational research approaches. The IRFN is a research education program that includes didactic experiences and close mentoring designed to augment the number of scientists equipped to tackle emerging challenges in neuroHIV.

PI_NAMEs: CHERNER, MARIANA  (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Advisory Committees;Area;base;Basic Science;Behavioral;Brain;brain health;Caliber;career;Central Nervous System;Clinical;clinical application;Clinical Sciences;Communicable Diseases;Competence;Complex;Consequences of HIV;Crystallization;Dedications;design;Development;Discipline;Education;education planning;education research;Educational Curriculum;Educational Models;Educational process of instructing;Environment;Epidemic;equity, diversity, and inclusion;Evaluation;evidence base;experience;Extramural Activities;Faculty;Fellowship;flexibility;Funding;Future;Genetic;Grant;Health Care Costs;Health Priorities;HIV;HIV Infections;Home;Immersion;Immunology;Individual;Individuation;interdisciplinary approach;Interdisciplinary Study;interest;International;Knowledge;Laboratories;Learning;lectures;Left;life-long learning;Link;Mentors;Mentorship;Mining;Modality;Modernization;Molecular;Molecular Biology;multidisciplinary;National Institute of Mental Health;neuroAIDS;neurobehavioral;neuroimaging;neuropathology;Neuropsychology;Neurosciences;Participant;Pathologic Processes;patient oriented;phenomenological models;Pilot Projects;Postdoctoral Fellow;pre-clinical;Problem Solving;programs;Public Health;Recording of previous events;recruit;Research;Research Ethics;Research Infrastructure;Research Personnel;Research Priority;Research Training;Resources;Science;Scientist;skills;Structure;success;Talents;Technology;Thinking;Training;translational approach;translational goal;translational model;Translational Research;United States National Institutes of Health;virology;Virus Replication;Work;Writing

PROJECT_TITLE: Interdisciplinary Research Fellowship in NeuroAIDS


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

PHR: Trainees receive an MD degree and a PhD in a medically-relevant field of research. Program graduates are optimally prepared to establish research-based careers in which the goal is to improve the public's health.

PI_NAMEs: COLLINS, KATHLEEN L. (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TITLE: Michigan Medical Scientist Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: NARRATIVE The prevalence of Alzheimer’s Disease is rising, but existing medications provide only modest control of cognitive decline and associated symptoms, and novel therapies are urgently needed. This randomized controlled trial will determine if an innovative low-risk neurostimulation at home can improve cognitive performance and symptoms in patients with mild to moderate Alzheimer’s Disease. If effective, this novel intervention can substantially enhance Alzheimer’s Disease symptom management at home, improve quality of life of Alzheimer’s Disease patients and their families, and reduce burden associated with this debilitating illness.

PI_NAMEs: KNOTKOVA, HELENA ;VERGHESE, JOE  (contact)

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: Adherence;Adverse effects;aged;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;Animal Model;arm;associated symptom;Behavioral;Benefits and Risks;Brain;brain metabolism;Brain region;Caregivers;Characteristics;Client satisfaction;Clinical;Clinical dementia rating scale;clinical efficacy;Clinical Trials;Clinical Trials Design;Cognitive;cognitive control;cognitive performance;cognitive task;cognitive testing;comorbidity;Coupled;dementia care;Depressed mood;design;Development;Devices;Diffusion Magnetic Resonance Imaging;Disease;Dose;Double-Blind Method;effective therapy;Electrodes;executive function;Family;FDA approved;fluorodeoxyglucose;follow-up;Frequencies;Functional Magnetic Resonance Imaging;geriatric depression;Healthcare Systems;Home;Human;Impaired cognition;improved;Individual;informal caregiver;innovation;Intervention;Intervention Studies;Measures;Medical;Metabolic;minimal risk;Monitor;Moods;Neurobehavioral Manifestations;neuroimaging marker;Neuronal Plasticity;Neurons;neuroregulation;Nonpharmacologic Therapy;novel;novel therapeutics;older adult;Outcome Assessment;Participant;Patients;Performance;Pharmaceutical Preparations;Pilot Projects;Placebos;Population;Positron-Emission Tomography;post intervention;Prefrontal Cortex;Prevalence;primary outcome;Procedures;Protocols documentation;Quality of life;Questionnaires;Randomized;Randomized Controlled Clinical Trials;randomized, clinical trials;Randomized, Controlled Trials;reduce symptoms;Reproducibility;response;Rest;Risk;secondary outcome;Secure;selective attention;side effect;Societies;Surveys;symptom management;Symptoms;Tablets;telehealth;Testing;Time;Training;transcranial direct current stimulation;United States;Videoconferencing

PROJECT_TITLE: Non-Invasive Home Neurostimulation for Mild to Moderate Alzheimer's Disease: Double-Blind, Sham Controlled Randomized Clinical Trial

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Infectious Diseases;Sexually Transmitted Infections;Urologic Diseases;Women's Health Research

ORG_CITY: SAN MARTIN

ORG_COUNTRY: ARGENTINA

ORG_FIPS: AR

ORG_NAME: INSTITUTE/RESEARCH/BIOTECHNOLOGY FDN

ORG_ZIPCODE: B 1650HMP

PHR: Trichomoniasis is a sexually transmitted disease (STI) with important public health ramifications; it has been associated with vaginitis, cervicitis, urethritis, and pelvic inflammatory disease. Trichomoniasis also impacts upon birth outcomes, increased susceptibility to HIV infection and cervical cancer in women. Because of increased resistance to treatment and the important health consequences of infection, new research is needed to understand the mechanism the pathogenesis and to identify new drug targets within the parasite. We propose to analyze the role of DNA methylation in the regulation of gene expression and 3D genome architecture to understand how this mechanism contribute to T. vaginalis pathogenesis. The outcome of these studies will provide significant new insights into gene regulation and may lay the foundation for the basis for an attractive new drug targets against Trichomoniasis.

PI_NAMEs: DE MIGUEL, NATALIA  (contact);STROBL MAZZULLA, PABLO HERNAN

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: 3-Dimensional;Adenine;Adherence;Affect;Antibodies;Architecture;ATAC-seq;Bioinformatics;Biological Assay;Birth;Cell Communication;Cell Nucleus;Cells;Cervicitis;Chromatin;Chromatin Loop;Chromatin Structure;chromosome conformation capture;chronic infection;Code;cytotoxicity;Data;DNA;DNA Methylation;DNA Transposable Elements;Epigenetic Process;epigenetic regulation;epigenome editing;Epitopes;Etiology;Eukaryota;experimental study;extracellular;Foundations;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic Transcription;Genome;genome-wide;Goals;Health;Histone Acetylation;HIV;HIV Infections;Human;Infection;Infertility;Inflammatory;insight;Intercistronic Region;Malignant neoplasm of cervix uteri;Malignant neoplasm of prostate;Mastigophora;Methylation;Modeling;Molecular;Molecular Biology Techniques;Molecular Conformation;new therapeutic target;next generation sequencing;novel;Nuclear;Outcome;Outcome Study;Parasites;Parasitic infection;Parasitology;Pathogenesis;Pelvic Inflammatory Disease;Peptides;Play;Predisposition;preference;Pregnancy;Premature Birth;Process;Proteins;Public Health;recruit;Regulation;Regulator Genes;Regulatory Element;Repression;Research;Resistance;Risk;Role;Sexual Transmission;Sexually Transmitted Diseases;Structure;Testing;tool;Transcriptional Regulation;transcriptome;transcriptome sequencing;Trichomonas;Trichomonas Infections;Trichomonas vaginalis;Urethritis;urogenital tract;Vaginitis;Woman;Work

PROJECT_TITLE: DNA methylation, 3D genome organization and gene expression during Trichomonas vaginalis: host interaction

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Gene Therapy;Genetics;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Project Narrative RNA silencing is a natural process by which small RNAs “silence” genes (or turn genes off), and is required for fertility, brain development, and prevention of cancer. This project aims to understand how small RNAs control gene expression in humans. The proposed research will lead to a better understanding of human gene regulation and contribute to advances in harnessing RNA silencing for the treatment of human disease.

PI_NAMEs: MACRAE, IAN JOHN (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Address;Animals;Area;Biochemical;Biological Process;Biology;Brain;cancer prevention;Cells;Complex;Cullin Proteins;Development;DNA Transposable Elements;Double-Stranded RNA;Fertility;Gene Expression;Gene Expression Regulation;Gene Silencing;Genes;Genome;Health;Hepatitis C virus;Human;human disease;insight;Integral Membrane Protein;Knowledge;Liver;Mammals;Membrane Transport Proteins;Messenger RNA;MicroRNAs;Molecular Genetics;piRNA;Process;Production;protein complex;Research;RNA;RNA Interference;RNA Transport;RNA Viruses;Small Interfering RNA;Small RNA;Structural Biochemistry;structural biology;Structure;therapeutic RNA;Transcriptional Silencer Elements;Translations;ubiquitin-protein ligase;Ubiquitination;Viral;Viral Genome;viral RNA;Virus Diseases;Work

PROJECT_TITLE: Structural and Mechanistic basis for RNA Silencing


ORG_CITY: NEW YORK

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative: The proposed training program will support the training of a diverse group of predoctoral students in genetics and cell biology, with direct implications for human health and disease. The training includes clinically relevant coursework and research opportunities and will prepare trainees for a range of careers in the biomedical workforce.

PI_NAMEs: RISCA, VIVIANA I;STEARNS, TIM  (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TITLE: Genetics and Cell Biology Training Program


ORG_CITY: LOS ANGELES

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The major goal of the proposed project is to test the role of GSTP1 in aggressive prostate cancer. The study will also define novel mechanisms through which GSTP1 contributes to the development of the advanced disease. Completion of the proposed research will give us insights into new mechanisms underlying the development of aggressive prostate cancer and open novel avenues for therapeutic interventions.

PI_NAMEs: STOYANOVA, TANYA I (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: Advanced Development;advanced disease;advanced prostate cancer;Aggressive Clinical Course;aggressive therapy;androgen deprivation therapy;androgen independent prostate cancer;Androgens;Automobile Driving;Binding;Cancer Etiology;Castration;Cells;Cessation of life;Cisplatin;clinically relevant;cohort;combat;Combined Modality Therapy;Development;Disease;Down-Regulation;Drug Metabolic Detoxication;Enzymes;Epithelial Cells;Family;FDA approved;Future;Glutathione S-Transferase;Glycolysis;Goals;Growth;GSTP1 gene;hormone therapy;Human;Incidence;inhibitor;insight;Life Expectancy;Malignant neoplasm of prostate;member;men;Metastatic Prostate Cancer;Modeling;Molecular;mortality;Neoplasm Metastasis;neuroendocrine phenotype;Neurosecretory Systems;new combination therapies;novel;novel strategies;novel therapeutic intervention;overexpression;Pathway interactions;patient derived xenograft model;Patients;Phenotype;Play;pre-clinical;preclinical study;Prostate;prostate cancer metastasis;Proteins;Proteomics;Proto-Oncogene Proteins c-akt;Recurrence;Relapse;Research;Resistance;response;Role;Signal Transduction;standard of care;Testing;Therapeutic;Therapeutic Agents;therapeutic candidate;therapeutic evaluation;Therapeutic Intervention;therapeutic target;therapy resistant;Time;Tissues;tumor;tumor growth;tumor xenograft;United States

PROJECT_TITLE: Delineate the Role of GSTP1 in Advanced Prostate Cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Post-Traumatic Stress Disorder (PTSD);Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research;Youth Violence;Youth Violence Prevention

PHR: NARRATIVE Justice-involved Black/African American female adolescents and their parents/caregivers are particularly vulnerable to post-traumatic stress disorder (PTSD) due to unique life histories and exposure to trauma. Unfortunately, few, if any, PTSD prevention interventions have been tested with this population to address their unique life experiences. The proposed project will use healing tenets to adapt and test a stress reduction intervention with justice-involved Black/African American female adolescents and parent/caregiver dyads to address the critical gaps in health and mental health disparities, interventions, and scientific knowledge to promote health equity and healing in this vulnerable, underserved population.

PI_NAMEs: QUINN, CAMILLE R. (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Address;Adolescent;African American;African American Women;Age;barrier to care;Behavior;behavior change;Behavioral;Biological;biological adaptation to stress;Biological Markers;Black race;boys;Caregivers;Child Abuse;Child Rearing;chronic pain;Chronic stress;Clinical;clinically significant;Communities;Conflict (Psychology);County;court;Crime;Data;design;Development;Diversion Program;Dreams;Drops;Emotional;Enrollment;experience;Exposure to;Family;Feedback;Female Adolescents;Focus Groups;Fostering;Future;girls;Goals;healing;Health;health disparity;health equity;health equity promotion;Hearing;Home;Hostility;Hydrocortisone;hypothalamic-pituitary-adrenal axis;implementation evaluation;improved;Individual;Inflammation;innovation;Institution;interdisciplinary approach;intersectionality;Intervention;Interview;Investigation;iterative design;Justice;juvenile justice system;Knowledge;Life Experience;life history;Link;Literature;Lived experience;male;maltreatment;Manuals;Mental Health;Methods;mindfulness;mindfulness-based stress reduction;Modeling;multimodality;National Institute on Minority Health and Health Disparities;Nature;novel strategies;Outcome;Outcome Study;Parent-Child Relations;Parents;Participant;Patient Self-Report;perceived stress;Personal Satisfaction;Phase;physical conditioning;Physiological;pilot test;Population;Post-Traumatic Stress Disorders;Prevention;preventive intervention;primary outcome;probation;procedure safety;Psychopathology;psychosocial;racial identity;recidivism;recruit;Reduce health disparities;Reporting;Research;Residential Treatment;response;Risk;secondary outcome;Secure;social culture;Social support;Stress;Stress and Coping;stress reduction;Surveys;Symptoms;Testing;Theoretical Domains framework;theories;therapy design;therapy development;Trauma;trauma exposure;Underserved Population;United States;Violence;Youth

PROJECT_TITLE: Exploring PTSD Symptoms, Barriers and Facilitators to Mindfulness-based Stress Reduction for Justice-Involved Black/African American Female Adolescents and Parents/Caregivers

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Narrative By unleashing the potential of UNICEF’s Multiple Indicator Cluster Surveys, the proposed project will create a powerful new data resource for population health researchers worldwide. Once fully harmonized and freely disseminated through a sophisticated, user-friendly website, the MICS data can be used to study global health issues affecting woman and children in a rigorous and reproducible manner. By enabling research on maternal and child health across time and space, this project will have a major impact on public health policy on a global scale.

PI_NAMEs: BOYLE, ELIZABETH H (contact);KING, MIRIAM L;SOBEK, MATTHEW

PROGRAM_OFFICER_NAME: JEKIELEK, SUSAN

PROJECT_TERMS: Adolescent;Adult;Affect;African;Age;Area;Back;Censuses;Child;Child Development;Child Health;Child Labor;Code;comparative;Comparative Study;Computer software;Conflict (Psychology);Contraceptive Usage;cost effective;Country;Data;data access system;data integration;data interoperability;data resource;Data Set;Databases;Demographic and Health Surveys;design;Discipline;Disease;Documentation;Eastern Europe;Education and Outreach;Educational Models;Educational workshop;Ensure;Environment;experience;Fertility Preferences;Fertility Study;Free Will;Funding;Geography;global health;Health;Health behavior;health disparity;Health Policy;Health Surveys;Home;Household;Human Development;improved;Individual;Infrastructure;innovation;International;Internet;interoperability;Investigation;Knowledge;Label;large scale data;life span;Link;marginalized community;Maternal and Child Health;Maternal Mortality;member;Metadata;metadata standards;Minnesota;Minority Groups;Mission;Modeling;Names;National Institute of Child Health and Human Development;Neonatal Mortality;novel;Online Systems;Orphan;outreach;Personal Satisfaction;Policy Maker;Population;Population Dynamics;population health;Portuguese;Protocols documentation;Public Health;Refugees;Reproducibility;Reproductive Health;Research;Research Design;Research Personnel;Resources;response;Sampling;Shapes;skills;social;software development;Source;Spanish;Surveys;System;Time;tool;United Nations;Universities;user-friendly;Violence;web site;webinar;Woman;Work

PROJECT_TITLE: Integrated Global Health on Child Health and Development

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Infectious Diseases;Neurosciences

ORG_CITY: NORTHRIDGE

ORG_DEPT: BIOLOGY

ORG_NAME: CALIFORNIA STATE UNIVERSITY NORTHRIDGE

PHR: Project Narrative Many parasitic nematodes require insect vectors for transmission, but it is not well known how these species modify their host seeking behavior between insects and humans. We use a genetically tractable nematode model with insect host association to study which genes affect preferences for taste and smell during development. A comparison of how homologous genes control neuronal fates across different species could reveal important molecular regulators for wiring chemosensory behavior and thus improve preventive measures for interfering with host detection.

PI_NAMEs: HONG, RAY L (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Address;Adolescent;Adult;Affect;Afferent Neurons;Animals;Behavior;behavior test;Behavioral;Caenorhabditis elegans;Calcium;cell type;Cells;Cellular Morphology;Chemotaxis;Clustered Regularly Interspaced Short Palindromic Repeats;comparative;Comparative Study;Complex;Cues;Data;Defect;Detection;Development;Ensure;Esthesia;Exhibits;forward genetics;Gene Expression;gene regulatory network;Genes;Genetic;Genetic Markers;Genetic study;Genetic Transcription;genome annotation;Germ Lines;Health;Histamine;homeodomain;Homologous Gene;Human;Hydroxysteroid Dehydrogenases;improved;in vivo;Individual;Insect Vectors;Insecta;Ions;knock-down;Knock-out;Larva;Life Cycle Stages;Mammals;Maps;mature animal;Mediating;model organism;Modeling;Molecular;mutant;Nematoda;Nervous System;Neuroanatomy;Neuronal Differentiation;Neurons;Odors;Parasites;Parasitic nematode;Pathway interactions;Persons;Play;preference;Preventive measure;Preventive treatment;Process;Publishing;reproductive;Research;Research Support;response;reverse genetics;Role;sensor;Sensory;Smell Perception;Sodium Chloride;System;Taste Perception;Taste preferences;Testing;transcription factor;Transgenes;Translating;transmission process;vector transmission;Visualization;Zinc Fingers

PROJECT_TITLE: Mapping of chemosensory neuron function to uncover changes in neuronal fates


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The proposed research aims to establish general and flexible synthetic approaches and methodologies to enable access of bioactive natural products and other medicinally important molecules, which are otherwise very difficult to acquire due to their scarcity, structural complexity, and high cost. This research will also open new avenues toward chemical libraries featuring structurally novel small molecules that incorporate the key structural elements of the selected natural molecules for anticancer, antimicrobial, and anti-neurodegenerative drug discovery. The strategies and methodologies developed in this research will significantly enrich the toolbox of both synthetic chemists and medicinal chemists.

PI_NAMEs: DAI, MINGJI  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Alkaloids;anti-cancer;antimicrobial;bioactive natural products;Biological;Biology;cancer therapy;chemical synthesis;Collection;Communicable Diseases;Complex;cost;Development;drug discovery;Drug Industry;Drug resistance;Elements;Evaluation;flexibility;Goals;Health;Human;in vivo;innovation;Institution;Lead;lead optimization;Medicine;Methodology;Natural Products;Natural Selections;Nerve Degeneration;Nervous System Disorder;novel;novel lead compound;novel therapeutics;Organic Synthesis;Outcomes Research;Problem Solving;programs;rational design;Reaction;Research;research clinical testing;small molecule;small molecule libraries;Terpenes;Therapeutic;therapeutic development

PROJECT_TITLE: Synthesis and Study of Medicinally Important Molecules


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Kidney Disease;Orphan Drug;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Although immune checkpoint inhibitors targeting the PD-1 pathway have transformed the management of advanced renal cell carcinoma, the majority of patients do not receive long-term benefit from these therapies, and the determinants of therapeutic response in this immunobiologically distinct tumor type remain largely unknown. By leveraging our expertise in immunogenomics and our unique access to large, clinically annotated, genomic cohorts, we aim to uncover the key genetic and immune determinants of effective, immune checkpoint inhibitor-mediated, anti-tumor immunity in renal cell carcinoma. Overall, this work will impact public health by revealing key mediators of therapeutic response and resistance and by identifying new therapeutic targets for immunomodulation in patients with advanced kidney cancer.

PI_NAMEs: BRAUN, DAVID  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: 9p21.3;Address;advanced disease;Advanced Malignant Neoplasm;Apoptosis;cancer cell;cancer infiltrating T cells;CD8-Positive T-Lymphocytes;Cell Communication;Cell Physiology;Cells;Cessation of life;Chromosome Deletion;Clear cell renal cell carcinoma;Clinical;clinical translation;cohort;Collaborations;Cryopreservation;cytokine;Data;Detection;Disease;exhaust;exome sequencing;Flow Cytometry;Frequencies;Gene Mutation;Genetic;Genetic Transcription;genomic data;Genomics;high dimensionality;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune response;Immunofluorescence Immunologic;immunogenic;Immunogenomics;immunoregulation;immunosuppressive macrophages;Immunotherapeutic agent;In Situ;industry partner;Knowledge;Macrophage;Mediating;Mediator;Medicine;Methods;Modeling;Mutation;Nature;neoantigens;Neoplasm Metastasis;new therapeutic target;Patients;PD-1 pathway;pharmacologic;Phenotype;Population;Primary Neoplasm;Production;Prognosis;Proliferating;Public Health;Recurrence;Renal Carcinoma;Renal Cell Carcinoma;Resistance;response;Role;single-cell RNA sequencing;Solid Neoplasm;Specimen;Statistical Models;Stromal Cells;T cell infiltration;T-Lymphocyte;Therapeutically Targetable;therapy resistant;transcriptome sequencing;transcriptomics;treatment response;tumor;Tumor Burden;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;United States;Validation;Work

PROJECT_TITLE: Tumor and immune determinants of effective anti-tumor immunity in renal cell carcinoma

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Nanotechnology

ORG_CITY: BATON ROUGE

ORG_DEPT: PATHOLOGY

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: Project Narrative  The goal of this project is to develop an innovative drug development platform for antiviral precision medicine. By integrating molecular pattern matching, DNA-based nanotechnology, customizable high- throughput safe pseudoviral detection and inhibition assays, live virus binding and inhibition validations, along with an animal model of COVID-19, we program, synthesize, screen, validate and optimize designer DNA- based nanoconstructs (DDNs) that can directly recognize and block enveloped viruses through their distinct surface epitope distribution features. The designed DDNs exhibited super sensitive binding and potent antiviral effects, suggesting that this DDN designing platform may contribute to a rapid development of antiviral precision medicine against emerging SARS-CoV-2 variants that are highly transmissible and/or resistant to convalescent sera, as well as other enveloped viruses such as influenza and HIV.

PI_NAMEs: HUANG, WEISHAN  (contact);WANG, XING

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 2019-nCoV;ACE2;Agar Gel Electrophoresis;Animal Model;anti-viral efficacy;Anti-viral Therapy;Antigens;antiviral drug development;aptamer;Area;Atomic Force Microscopy;Avidity;Binding;Biological Assay;biomaterial compatibility;Cell model;Cells;Characteristics;Collection;cost;cost estimate;COVID-19;cytotoxic;cytotoxicity;design;Detection;Development;DNA;Dose;drug development;Effectiveness;Emerging infection;emerging virus;Engineering;Epithelial Cells;Epitopes;Etiology;Exhibits;flexibility;future epidemic;genetic technology;Goals;HIV;Human;In Vitro;in vivo;Infection;Influenza;innovation;innovative technologies;Knock-in Mouse;Knowledge;Lung;Mechanics;Medicine;Membrane Glycoproteins;Membrane Proteins;mimicry;Molecular;Molecular Genetics;mouse model;nano;nanobodies;nanoscale;Nanostructures;Nanotechnology;pandemic disease;particle;pathogen;Pattern;Positioning Attribute;post SARS-CoV-2 infection;precision medicine;prevent;Preventive;Price;programs;Property;prophylactic;Proteins;prototype;receptor;receptor binding;Resistance;Route;Safety;SARS-CoV-2 B.1.1.529;SARS-CoV-2 B.1.617.2;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;SARS-CoV-2 P.1;SARS-CoV-2 spike protein;SARS-CoV-2 variant;screening;Sensitivity and Specificity;Series;Shapes;Structure;Surface;Technology;Testing;Therapeutic;Toxic effect;transmission process;United States National Institutes of Health;Validation;variants of concern;Viral;viral entry inhibitor;Virion;Virus;Virus Diseases;Work

PROJECT_TITLE: Programming designer DNA nanostructures for blocking enveloped viral infection

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


NIH_SPENDING_CATS: Genetics

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: RELEVANCE (See instructions): Plasmacytoid dendritic cells (pDCs) play an important role in immune responses to infection and in autoimmunity, and therefore represent attractive targets for novel immunoterapies. The proposed work aims to build a comprehensive molecular view of pDC development and function, paving the way for pDCfocused translational approaches in human diseases.

PI_NAMEs: REIZIS, BORIS  (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Address;Anti-viral Response;Autoimmune Diseases;Autoimmunity;Award;Binding Sites;Cell Differentiation process;Cell Lineage;cell motility;Cell Physiology;cell type;Cells;Cellular biology;chemokine receptor;cohesin;Confocal Microscopy;CRISPR screen;CRISPR/Cas technology;Custom;CXCR3 gene;cytokine;Dendritic cell activation;Dendritic Cells;design;Development;Dissection;draining lymph node;Dropout;E protein;Endogenous Retroviruses;Endosomes;Enhancers;follow-up;Gene Cluster;Gene Targeting;Genes;Genetic;genetic approach;Genetic Enhancer Element;Genetic Transcription;Goals;Heterogeneity;high dimensionality;Homeostasis;Human;human disease;IFNAR1 gene;Image;Immune response;Immunochemistry;In Vitro;in vivo;Individual;Infection;Inflammatory;Instruction;Integrins;Interferon alpha;Interferon Type I;Interferon-beta;Interferons;Lentivirus Vector;Libraries;loss of function;Lymph Node Subcapsular Sinus;Macrophage;Mediating;Methods;microbiome;migration;Mitochondrial DNA;Modeling;Molecular;multiphoton microscopy;Mus;novel;Nucleic Acids;Peripheral;Phenotype;Play;preservation;Process;Production;Progress Reports;promoter;Publishing;Regulation;Regulatory Element;Reporter;Reporting;response;Role;Signal Pathway;Signal Transduction;single cell analysis;Skin;Specific qualifier value;Stimulator of Interferon Genes;Systemic Lupus Erythematosus;TCF7L2 gene;Testing;Therapeutic;therapeutic target;Time;transcription factor;Transcriptional Regulation;translational approach;Vesicular stomatitis Indiana virus;Virus;Virus Diseases;Work

PROJECT_TITLE: Molecular Control of Plasmacytoid Dendritic Cell Development and Function

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Human Genome;Pediatric

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: PROJECT NARRATIVE Retinoic acid is the active form of vitamin A that controls eye development by turning specific genes on or off. In this project we propose studies that will identify the key genes through which retinoic acid controls eye development. By learning how retinoic acid normally controls eye development in vivo, these studies will provide basic knowledge valuable for determining how developmental eye defects occur and for improving strategies to treat eye defects.

PI_NAMEs: DUESTER, GREGG L (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Address;ALDH1A2 gene;All-Trans-Retinol;ATAC-seq;Binding;Biological Assay;Candidate Disease Gene;candidate identification;ChIP-seq;Chromatin;Cleavage Under Targets and Release Using Nuclease;Clustered Regularly Interspaced Short Palindromic Repeats;conditional knockout;Defect;Deposition;Development;Diffusion;Disease;DNA;Embryo;Embryonic Development;Enhancers;EP300 gene;Epigenetic Process;Exhibits;Eye;Eye Development;eye formation;Failure;FOXC1 gene;Gene Activation;gene function;gene regulatory network;gene repression;Gene Silencing;Genes;genetic corepressor;Genetic Enhancer Element;Genetic Transcription;Genome;Goals;Growth;Human;improved;in vivo;insight;interest;Knock-out;Knowledge;Learning;LoxP-flanked allele;Mesenchyme;Methods;Microphthalmos;Morphogenesis;Morphology;Mus;mutant;Mutation;NCOR1 gene;Neural Crest;novel strategies;Nuclear;Nuclear Receptors;optic cup;Optic vesicle;Optics;posttranscriptional;recruit;Repression;retinaldehyde dehydrogenase;Retinoic Acid Binding;Retinoic Acid Receptor;Retinoic Acid Response Element;Retinol dehydrogenase;Signal Pathway;Testing;Tissues;Transcriptional Regulation;transcriptome sequencing;Transgenes;Tretinoin;Untranslated RNA;Vitamin A

PROJECT_TITLE: Retinoic acid target genes and transcriptional mechanisms during eye development

STUDY_SECTION: BVS

STUDY_SECTION_NAME: Biology of the Visual System Study Section[BVS]


ADMINISTERING_IC: AR

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Pain Research;Pediatric;Physical Injury - Accidents and Adverse Effects;Rehabilitation

ORG_CITY: Newark

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE Adolescents with Achilles tendon injury may suffer long-term health detriments and impediments to physically active lifestyles due to a poor understanding of the health and functional impact of heel pain in patients under 18 years old. This project will investigate the effect of heel pain on adolescent Achilles tendon health and lower limb biomechanics. Findings from this research will provide necessary evidence for establishing the pathoetiology of adolescent heel pain, as proper injury diagnosis will allow adolescents with heel pain to receive the appropriate clinical care and maintain physically active lifestyles into adulthood.

PI_NAMEs: SEYMORE, KAYLA  (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: 18 year old;3-Dimensional;achilles tendon;active lifestyle;Adolescence;Adolescent;Adult;Advocate;aged;Ankle;Area;Articular Range of Motion;Biomechanics;calcaneum;career;Child;Childhood;Clinical;clinical care;clinical diagnosis;clinical diagnostics;Computer Models;Cumulative Trauma Disorders;Delaware;Development;Diagnosis;Disease;elastography;Epiphysial cartilage;Etiology;Exhibits;Fellowship;Foundations;functional adaptation;Functional impairment;Goals;Growth;Health;Health Sciences;Heel;Height;Imaging Techniques;Impairment;improved;in vivo;Incidence;Injury;innovation;loss of function;Lower Extremity;mechanical properties;Morphology;Motion;Muscle;muscle strength;Musculoskeletal;musculoskeletal injury;novel;Pain;Pathology;Patients;Physical activity;Population;Populations at Risk;post-doctoral training;premature;pressure;Quality of life;Questionnaires;reduce symptoms;Rehabilitation therapy;Reporting;Research;research clinical testing;Research Personnel;Retirement;Running;Scientist;Severities;Sports;Stress;Symptoms;Task Performances;Techniques;Tendinopathy;Tendon Injuries;Tendon structure;Testing;Training;Triceps Brachii Muscle;ultrasound;Universities;Walking;Work;youth sports

PROJECT_TITLE: Assessment of Achilles Tendon Injury in Adolescents


NIH_SPENDING_CATS: Maternal Health;Pediatric;Pregnancy;Women's Health Research

ORG_CITY: Aurora

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The function of the placenta determines life-long health because changes in placental function play an important role in the development of many pregnancy complications and increases the risk of developing diseases such as obesity, diabetes, cardiovascular disease and cancer in adult life. Our understanding of placental function is however limited, in part because there are currently few scientific meetings specifically focused on the placenta that brings together the best researchers from different disciplines to solve the most urgent questions. To meet this need, we propose to organize a unique annual meeting focused on the role of the placenta in causing diseases of profound public health significance.

PI_NAMEs: JANSSON, THOMAS  (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Address;Adult;Americas;Applications Grants;Area;Brain;Cardiovascular Diseases;career;Cellular biology;Clinical Investigator;Complex;cost;Creativeness;Dedications;design;Development;Diabetes Mellitus;Discipline;Disease;educational atmosphere;epidemiologic data;Fertilization;fetal;Fetal Diseases;Fetal Growth Retardation;Fetal Macrosomia;Fetus;Functional disorder;Future;Goals;graduate student;Grant;Health;Hour;Human;in vivo;innovation;interdisciplinary approach;Intervention;Investigation;investigator training;lectures;Life;Link;Malignant Neoplasms;Mediating;meetings;Metabolic Diseases;Molecular;Molecular Biology;Monitor;multidisciplinary;Mus;novel;Obesity;obstetrical complication;Organ;Outcome;Pathway interactions;Physiology;Placenta;Placental Biology;Play;Pre-Eclampsia;Pregnancy Complications;programs;Public Health;Reproduction;reproductive;Research;Research Personnel;response;Risk;Role;Scientific Inquiry;Scientist;Societies;Structure;symposium;Techniques;Technology;Time;Training;Work

PROJECT_TITLE: Placenta Association of the Americas Conference Grant

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Prevention

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative (Relevance to Public Health) COVID-19 is an ongoing pandemic and threat to human health caused by SARS-CoV-2 infection. The effort of translating exosome discoveries into biomarker-guided therapeutic development will accelerate a better control of the virus and pandemic therefore benefiting the public health.

PI_NAMEs: FANG, DEYU ;LIU, HUIPING  (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;ACE2;acute infection;Angiotensin Receptor;Anti-viral Response;Antibodies;Antibody Specificity;Binding;Biological Assay;Biological Markers;Blood;Cancer Center;CD81 gene;Cells;Cessation of life;Clinical;clinical application;clinical biomarkers;Clinical Trials;commercialization;Communication;convalescent plasma;Coronavirus;COVID-19;COVID-19 pandemic;COVID-19 pathogenesis;COVID-19 patient;COVID-19 severity;COVID-19 therapeutics;COVID-19 treatment;deep learning algorithm;Detection;Devices;Diagnosis;Diameter;Disease;Epithelium;Epitopes;exosome;extracellular vesicles;Future;Good Manufacturing Process;Health;Hospitalization;Human;improved outcome;industry partner;Infection;innovation;Institution;intercellular communication;Kidney;Mediating;Medicine;Membrane Lipids;Membrane Proteins;microvesicles;Molecular;Multivesicular Body;Nature;neutralizing antibody;novel;novel therapeutics;Nucleic Acids;Outcome;pandemic disease;Patients;Persons;Phase;Plasma;pneumocyte;Pre-Clinical Model;preclinical study;preclinical trial;prevent;Prevention;Production;Proteins;Protocols documentation;Public Health;receptor;receptor binding;Recombinants;Research Personnel;response;SARS coronavirus;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;scale up;severe COVID-19;Stains;targeted treatment;Technology;Therapeutic;therapeutic development;Translating;Translations;TSG101 gene;Universities;Vaccinated;Vaccination;Validation;Variant;Viral;Virus;Virus Replication;Vulnerable Populations

PROJECT_TITLE: Clinical analysis and therapeutic development of exosomal ACE2

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Aging;Arthritis;Genetics;Osteoarthritis

ORG_CITY: SAINT LOUIS

ORG_DEPT: ORTHOPEDICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: RELEVANCE Osteoarthritis (OA) is a disease that affects 54 million people in the United States. Despite advances in therapeutics across medicine, there remains no disease-modifying OA drugs (DMOADs). While joint replacement therapy restores mobility and controls symptoms, it is the most costly hospital treated medical condition for Medicare patients in the USA. Thus, there is critical need for better understanding of OA and the identification of new targets for the development of disease modifying treatments. This proposal provides new mechanistic insights toward understanding the role of TGF (via TAK1) and Igf1 in regulation of chondrocyte homeostasis and glucose metabolism, especially glycolysis and HBP in OA. We expect to identify new targets and pathways as new strategies to treat OA.

PI_NAMEs: O'KEEFE, REGIS J (contact);SHEN, JIE

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Ablation;Acceleration;Acetyl Coenzyme A;Address;Affect;Aging;Anabolism;articular cartilage;Attenuated;blood glucose regulation;Carbon;Carrier Proteins;Cartilage;Catabolism;Chondrocytes;Citrates;Clinical Treatment;Cytoplasm;Data;Degenerative polyarthritis;Development;Disease;Enzymes;Equilibrium;fructose-6-phosphate;gain of function;Gene Deletion;Gene Expression;Genes;Genetic;genetic approach;Glucose;glucose metabolism;glucose uptake;Glutamine;Glycolysis;Glycosaminoglycans;Goals;Hexosamines;High Pressure Liquid Chromatography;Homeostasis;Hospital Costs;Hyaluronic Acid;IGF1 gene;In Vitro;in vitro Model;in vivo;Injury;innovation;insight;joint injury;Joints;Knowledge;Label;loss of function;MAP3K7 gene;Mass Spectrum Analysis;Mediating;Medical;Medicare;Medicine;Metabolic;metabolomics;Mitochondria;Mus;novel;overexpression;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;prevent;Production;Proteoglycan;Radiolabeled;receptor;receptor expression;Receptor Gene;Regulation;Replacement Arthroplasty;Replacement Therapy;response;Role;Signal Transduction;Source;Symptoms;Therapeutic;therapeutic target;transcriptome sequencing;United States;Up-Regulation;uptake;Work

PROJECT_TITLE: Metabolic Regulation of Articular Cartilage and Joint Homeostasis


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Cerebrovascular;Clinical Research;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Pediatric;Women's Health Research

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE: Nearly 2% of youth in the United States identify as transgender and many seek treatment to block unwanted secondary sex characteristics and later start gender-affirming hormone treatments (testosterone or estradiol) so that their body aligns with their identity. The effects of these treatments on cardiovascular health and diabetes risk are significantly understudied in adults and adolescents. In this longitudinal, observational study, we will investigate effects of puberty blockers and estradiol on insulin resistance and vascular health in adolescent transgender females.

PI_NAMEs: NOKOFF, NATALIE J (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Adolescence;Adolescent;Adult;Age;arterial stiffness;Bilateral;biological sex;Birth;Blood flow;Blood Vessels;brachial artery;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;career;career development;Caring;Cephalic;cerebrovascular;Childhood;Chromosomes;cis-female;cis-male;cisgender;Clinic;Clinical;clinical care;clinical investigation;Clinical Investigator;Clinical Research;Clinical Sciences;cohort;Colorado;Counseling;design;Development Plans;diabetes risk;Doctor of Philosophy;Elasticity;Endocrinologist;Endocrinology;Endothelium;Environment;Equilibrium;Estradiol;Event;Exposure to;Faculty;Family;Female;Female Adolescents;Future;gender affirming hormone therapy;gender diversity;Gender Identity;Genetic;Glucose;Goals;Gonadal Steroid Hormones;Gonadotropin-Releasing Hormone Analog;Guidelines;Health;Health Transition;high risk;Hormonal;improved;Incidence;Individual;Insulin;Insulin Resistance;insulin sensitivity;International;Investments;Lead;Learning;longitudinal design;Longitudinal, observational study;male;Measures;Mediating;Medical;men;Mentors;Metabolic;Methods;middle age;middle cerebral artery;Modeling;multidisciplinary;Myocardial Infarction;novel;OGTT;Oral;patient oriented;Physiologic pulse;Population;Prevalence;primary outcome;programs;Puberty;puberty blocker;Recommendation;recruit;Research;research and development;Research Design;Research Support;Resources;Risk Factors;sex;Sex Characteristics;Sex Differences;skills;stroke incidence;Testosterone;therapy design;Thinness;Training;Training Activity;transgender;transgender women;Translational Research;treatment effect;treatment guidelines;ultrasound;United States;Universities;venous thromboembolism;Vulnerable Populations;Woman;Women's Health;Youth

PROJECT_TITLE: Pubertal Blockade and Estradiol Effects on Cardiometabolic Health for Transitioning Youth (PUBERTY)

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE Relapse and/or refractory acute myeloid leukemia (AML) display intrinsic resistance to targeted therapies. Venetoclax-resistant AML is functionally reliant upon MCL1 and consequently, vulnerable to MCL1 genetic or pharmacologic perturbation. This proposal aims to define the precise mechanisms by which MCL1 uniquely influences AML therapy resistance through a non-canonical role in regulating mitochondrial fission and β- oxidation, introducing novel pathways for further therapeutic intervention.

PI_NAMEs: ALTHOFF, MARK JORDAN (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Ablation;Activities of Daily Living;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Azacitidine;BCL1 Oncogene;BCL2 gene;Biological Assay;Biology;Cell Line;Cell Separation;Cells;Clinical;Co-Immunoprecipitations;Colony-forming units;Confocal Microscopy;crosslink;Data;Dependence;Development;Disease;Disease Resistance;Drug resistance;Dynamin;Electron Microscopy;Engraftment;Enzymes;Exhibits;fatty acid metabolism;fatty acid oxidation;Fatty Acids;Genetic;Hematologic Neoplasms;immunodeficiency;improved;In Vitro;inhibitor;interest;Jordan;Laboratories;leukemia treatment;leukemic stem cell;Ligation;Link;lipid metabolism;lipidomics;long chain fatty acid;Long-Chain-Acyl-CoA Dehydrogenase;Mass Spectrum Analysis;Measures;Mediating;metabolomics;Mitochondria;Mitochondrial Matrix;Molecular;molecular targeted therapies;Morphology;Mus;myeloid leukemia cell;Newly Diagnosed;novel;Outcome;Output;oxidation;Oxidative Phosphorylation;Pathology;Pathway interactions;Patients;pharmacologic;Phenotype;Phosphorylation;Production;Proteins;Recurrent disease;Refractory;Refractory Disease;Relapse;Reporting;Resistance;response;Role;Sampling;Specimen;targeted treatment;Therapeutic Intervention;therapeutic target;therapy resistant;trafficking;Xenograft procedure

PROJECT_TITLE: Understanding the unique dependency for MCL1 in Ven/Aza resistant AML


NIH_SPENDING_CATS: Aging;Clinical Research;Disability Research;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ORLANDO

ORG_NAME: ADVENTHEALTH ORLANDO

ORG_STATE: FL

PHR: Project Narrative The SOMMA project is a large-scale trial designed to determine key biological properties of skeletal muscle that are related to incident major mobility disability, declines in mobility and declines in fitness in older adults (> 70yr) over the course of three years, while also collecting adipose tissue (AT) and blood. The experiments proposed in this ancillary study will examine the influence of AT structure and function on AT-secreted proteins that are related with mobility disability and can directly impact skeletal muscle function. The proposed work will also quantify the AT-secreted proteins in circulation that are found to directly affect skeletal muscle function, as well as contribute all excess biospecimens to the parent SOMMA project biorepository for future use.

PI_NAMEs: KERSHAW, ERIN E.;SPARKS, LAUREN MARIE (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Address;adipose derived stem cell;Adipose tissue;Affect;Aging;aging biomarker;aging population;aging related;Ancillary Study;Archives;Atrophic;biobank;Biological;Biopsy;Blood;Blood specimen;CD4 Positive T Lymphocytes;Cd68;CDKN2A gene;Cell Aging;Cells;Cessation of life;Circulation;Collaborations;Contractile Proteins;Crowns;Data;Denervation;Diameter;Disability research;Enzyme-Linked Immunosorbent Assay;Etiology;experimental study;fitness;flexibility;functional outcomes;Funding;Future;Generations;glycemic control;Glycerol;Goals;Human;Hydrogen Peroxide;Immunoassay;improved;In Vitro;in vivo;Incubated;Inflammation;Insulin;Insulin Resistance;insulin sensitivity;Isoproterenol;Knowledge;life span;Link;lipid biosynthesis;Longitudinal Studies;Metabolic;Mission;Mitochondria;Mobility decline;Mobility disability;Morbidity - disease rate;mortality;mouse model;Muscle;Muscle Cells;Muscle Fibers;muscle form;Muscle function;Necrosis;novel;older adult;Outcome;oxidative damage;Oxidative Stress;Parents;Physiological Processes;Population;preservation;prevent;Prevention strategy;Process;Production;Property;protein expression;Protein Secretion;Proteins;Proteomics;Publishing;Quality of life;Reporting;Research Personnel;Resources;Respiration;Role;self-renewal;senescence;Skeletal Muscle;skeletal muscle wasting;stem cell proliferation;Structure;targeted treatment;translational impact;trial design;United States National Institutes of Health;VO2max;Walking;walking speed;Work

PROJECT_TITLE: Investigating the role of adipose tissue in mobility and aging (SOMMA-AT)


NIH_SPENDING_CATS: Aging;Atherosclerosis;Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Prevention

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Many genetic research studies have shown that a relatively obscure region on chromosome 2 is highly associated with human coronary artery disease, but how this region of the genome causes heart disease is unknown. This proposed study examines how this obscure region is linked with a gene associated with cancer, ZEB2, and shows how this gene can influence a person’s chance of a heart attack using a combination of state of the art tools including genome editing, cell and animal models, and genetic data at the level of single individual cells.

PI_NAMEs: CHENG, PAUL PO SHENG (contact)

PROJECT_TERMS: Advisory Committees;Affect;Animal Model;Arterial Fatty Streak;ATAC-seq;Atherosclerosis;atherosclerosis risk;Base Pairing;Binding;Biological Assay;Biological Process;Biology;Cardiovascular Diseases;career;causal variant;Cause of Death;Cell model;Cell Physiology;Cells;ChIP-seq;Chromatin Remodeling Factor;Chromosome 2;chromosome conformation capture;Clonal Expansion;Clonality;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Computational Biology;Coronary Arteriosclerosis;Coronary artery;CRISPR interference;Data;design;Development;disorder risk;Enhancers;Epigenetic Process;epigenetic profiling;epigenome editing;epigenomic profiling;Epithelium;Excision;Funding;Gene Expression Profiling;Genes;Genetic;Genetic Epistasis;Genetic Research;Genetic Risk;genetic risk factor;Genetic study;Genetic Transcription;Genome;genome editing;genome wide association study;genome-wide;genomic locus;Genomic Segment;Goals;Heart Diseases;Human;Human Genetics;In Vitro;in vivo;in vivo Model;Individual;insight;K-Series Research Career Programs;Lesion;Link;Luciferases;MADH3 gene;Malignant Neoplasms;Mediating;Mentors;Mesenchymal;migration;Modeling;Molecular;Movement;multiple omics;Mus;Myocardial Infarction;novel;novel therapeutics;Persons;Phenotype;Physicians;Play;prevent;Principal Investigator;programs;promoter;Proteins;Regulatory Element;Research Personnel;research study;Resolution;response;Risk;risk variant;Role;Rupture;Scientist;screening;Signal Pathway;Single Nucleotide Polymorphism;skill acquisition;Smad Proteins;Smooth Muscle Myocytes;Stimulus;Testing;tool;Training;transcription factor;Transcription Repressor;Transcriptional Regulation;transcriptome sequencing;transcriptomic profiling;transcriptomics;Translating;tumorigenesis;Universities;Untranslated RNA;Work

PROJECT_TITLE: From Locus to Function: Role of ZEB2 in Human Risk of Coronary Artery Disease

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;HIV/AIDS;Infectious Diseases;Pediatric;Prevention;Primary Immunodeficiencies;Rare Diseases

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: The protein SAMHD1 is of substantial medical interest because it functions both as a viral restriction factor and a modulator of the innate immune response. Numerous biochemical and cellular properties of SAMHD1 have been investigated, and some of these properties have been found to correlate with SAMHD1 antiviral activity. However, how SAMHD1 is regulated and the mechanisms by which SAMHD1 exerts its effects, both on viruses and the innate immune system, are not fully defined. Filling these knowledge gaps is crucial for both identifying novel antiviral targets and developing therapeutic approaches for the treatment of AGS.

PI_NAMEs: DIAZ-GRIFFERO, FELIPE  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Acetylation;Amino Acids;Anti-Retroviral Agents;Binding;Biochemical;CD4 Positive T Lymphocytes;Cessation of life;Data;Dendritic Cells;Detection;Development;Enzymes;Exhibits;Genes;HIV Infections;HIV-1;HIV-2;Human;Human Herpesvirus 2;Immune;In Vitro;in vivo;Infection;Infection prevention;innate immune function;Innate Immune Response;Innate Immune System;Institution;interest;Interferon Type I;Knockout Mice;Knowledge;Laboratories;Lentivirus;Life Cycle Stages;Limb structure;Macrophage;Mediating;Medical;mutant;Mutation;Natural Immunity;new therapeutic target;novel;Nucleic Acid Binding;Nucleic Acids;Nucleotides;Paralysed;Patients;Phenotype;Phosphorylation;prevent;Preventive vaccine;Privatization;Property;Proteins;pseudotoxoplasmosis syndrome;Publishing;Regulation;Reporting;Research Personnel;Resistance;resistant strain;response;Rest;Reverse Transcription;RNA;Role;sensor;Structure;T-Lymphocyte;Testing;Therapeutic;tool;transmission process;Treatment Protocols;tripolyphosphate;Viral;viral DNA;Viral Physiology;viral RNA;Virus;Virus Diseases

PROJECT_TITLE: Regulation of SAMHD1 antiviral activity


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Rare Diseases;Stomach Cancer

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Tumor heterogeneity has been recognized as one of the leading determinants of therapeutic resistance and treatment failure, contributing to poor clinical outcomes. However, the non-genetic, cell intrinsic origins of tumor cell heterogeneity remain poorly understood particularly in gastric cancer. This project is relevant to human health because it focuses on identification of the origins, evolution, and mechanisms that drive cellular heterogeneity of metastatic gastric cancer as well as how to target this heterogeneity to improve therapy.

PI_NAMEs: MAZUR, PAWEL K.;WANG, LINGHUA  (contact)

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: Aggressive behavior;anti-PD1 therapy;Architecture;Behavior;Biology;Cancer Biology;cancer cell;cancer therapy;Carcinomatosis;cell behavior;Cell Lineage;Cells;chemotherapy;Classification;Clinical;Clonal Evolution;cohort;Complex;Computer Models;Data;Development;Diagnosis;Disease Progression;Distal;Distant;Ecosystem;effective therapy;Ensure;Evolution;Exhibits;Feedback;Gastric Adenocarcinoma;Genetic;Genetically Engineered Mouse;Genomics;Genotype;Goals;Greater sac of peritoneum;Growth;Health;Heterogeneity;Human;Immune;Immunotherapy;improved;in vivo;Invaded;Link;Malignant Neoplasms;malignant stomach neoplasm;Measures;Medicine;Modeling;Molecular;mouse model;Nature;Neoplasm Metastasis;neoplastic cell;non-genetic;novel;Oncogenic;Organ;Outcome;Pathogenicity;Pathway interactions;patient response;Patient-Focused Outcomes;Patients;Peritoneal;pharmacologic;Phenotype;Population;Population Dynamics;Primary Neoplasm;Process;Property;Recurrence;Research;Resistance;Resolution;response;Risk;Role;Sampling;Signal Pathway;single cell analysis;Site;Source;standard of care;System;Therapeutic;therapy resistant;Time;transcriptome;transcriptomics;Treatment Failure;tumor;Tumor Cell Invasion;tumor growth;tumor heterogeneity;tumor progression;Tumor Promotion;tumor-immune system interactions;Tumor-infiltrating immune cells

PROJECT_TITLE: Tumor cell lineage diversity and composition in gastric cancer progression and therapy resistance

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Lung;Neonatal Respiratory Distress;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: ELM GROVE

ORG_NAME: RENEUROGEN, LLC

ORG_STATE: WI

PHR: Project Narrative Bronchopulmonary dysplasia (BPD) is a severe lung disease that occurs in 10% of all preterm births. About 15,000 BPD cases are reported per year in the US. The costs of caring for BPD patients in the Neonatal Intensive Care Unit (NICU) are over $350,000 each just in the first months of life. Such costs are over twice the amount required for NICU patients without BPD. This application aims to develop for human use a novel drug that improves lung development in animal models of BPD.

PI_NAMEs: NAYLOR, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Adolescent;Adult;Alveolar;Amides;Animal Model;Applications Grants;Attenuated;Biological Availability;Biomedical Engineering;Body Weight;Brain;Bronchopulmonary Dysplasia;Businesses;Canis familiaris;care costs;Case Study;Chemistry;Clinical;Clinical Chemistry;Clinical Pathology;Clinical Research;commercialization readiness;cost;Data;design;Development;Disease;Dose;Drug Kinetics;effectiveness evaluation;efficacy evaluation;Ensure;Evaluation;experimental study;food consumption;Foundations;Funding;Future;Goals;Growth;Hand;Hematology;Human;improved;in vivo;Inflammation;Inflammatory;inhibitor;interest;intraperitoneal;Intravenous;intravenous administration;Kidney;Life;Liver;Lung;lung development;Lung Diseases;lung injury;manufacturing scale-up;Medical;meetings;Modeling;Mus;National Heart, Lung, and Blood Institute;Neonatal;Neonatal Intensive Care Units;novel;novel therapeutics;Organ;Organ Weight;Oryctolagus cuniculus;Oxidants;Oxidative Stress;Oxygen Therapy Care;Patients;Peptides;Peroxidases;Pharmaceutical Preparations;Pharmacodynamics;Pharmacology;Phase;phase 2 study;pre-clinical;pre-Investigational New Drug meeting;preclinical development;preclinical safety;Pregnancy;premature;Premature Birth;Premature Infant;premature lungs;preterm newborn;prevent;Process;Production;programs;Publishing;pup;Rattus;Research Design;respiratory health;Risk;Route;Safety;Schedule;Shapes;Site;Small Business Innovation Research Grant;subcutaneous;supplemental oxygen;System;Therapeutic;Tissues;Toxic effect;Toxicokinetics;Toxicology;Urinalysis;Weight Gain;Writing

PROJECT_TITLE: Development of a systems pharmacology agent for treatment of bronchopulmonary dysplasia


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: MANHATTAN

ORG_DEPT: PSYCHOLOGY

ORG_NAME: KANSAS STATE UNIVERSITY

ORG_STATE: KS

PHR: PROJECT NARRATIVE: OVERALL This COBRE Phase 2 application proposes to continue to develop a unique, nationally recognized, thematic research center on Cognitive and Neurobiological Approaches to Plasticity (CNAP). Plasticity refers to the brain’s ability to change and adapt throughout life. CNAP researchers, supported by three multi-user core facilities, will study various aspects of plasticity in humans and animals using a range of research techniques.

PI_NAMEs: THOMPSON, DAVID EDWARD (contact)

PROGRAM_OFFICER_NAME: NANDA, JAGPREET SINGH

PROJECT_TERMS: Achievement;Alzheimer's Disease;Anatomy;Animal Model;Animals;Area;Arts;Avoidance Learning;Award;Behavioral;Brain;Centers of Research Excellence;Climate;Clinical Research;Cognitive;cognitive function;cognitive neuroscience;collaborative environment;college;Complement;Computer Models;Core Facility;design;Development;Discipline;Disease;Disease Progression;Eligibility Determination;Exercise;Extramural Activities;Faculty;Faculty Recruitment;Fostering;Funding;Future;Goals;Grant;Health;Human;improved;Individual;Institution;interest;Kansas;laboratory facility;Learning;Life;member;Memory;memory process;Modeling;Modernization;Neurobiology;neuroinformatics;neuromechanism;Neuronal Plasticity;Neurophysiology - biologic function;neuroregulation;Neurosciences;Pathway interactions;Phase;Physiology;Population;Process;Program Development;programs;psychologic;Rattus;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Research Technics;Resources;Rodent Model;Science;Scientist;Secure;success;synergism;Techniques;tenure track;Training;training opportunity;Translational Research;Veterinary Medicine

PROJECT_TITLE: Cognitive and Neurobiological Approaches to Plasticity (CNAP) Center Phase 2


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

PHR: PROJECT NARRATIVE: ADMINISTRATIVE CORE  Not applicable. See Overall plan.

PROJECT_TERMS: Achievement;addiction;Advisory Committees;Anatomy;animal imaging;Animals;Applications Grants;Area;Arts;Award;Behavioral;biomedical imaging;Biomedical Research;Centers of Research Excellence;Cognitive;cognitive neuroscience;Collaborations;college;Communicable Diseases;Core Facility;Development;Disease Pathway;Elements;Ensure;Evaluation;experience;Faculty;functional MRI scan;Future;Goals;Grant;Growth;Health;Hospitals;Human;imaging facilities;improved;Individual;Kansas;laboratory facility;Medical center;member;Mentors;Molecular Analysis;Neurobiology;neuroinformatics;Neuronal Plasticity;Neurosciences;Nevada;North Dakota;operation;Phase;Physiology;Play;programs;psychologic;recruit;Research;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Role;Science;skills training;success;tenure track;Training Programs;Transcranial magnetic stimulation;Universities;Veterinary Medicine;visual neuroscience;Work;Writing;Zoonoses

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Pediatric;Prevention

ORG_CITY: PORTLAND

ORG_NAME: OREGON MUSEUM OF SCIENCES AND INDUSTRY

ORG_STATE: OR

PHR: Project Narrative The Wildfire and Human Health in a Changing Climate project will develop a 1,400-square-foot bilingual (Spanish/English) traveling exhibition, accompanying website, and related educational resources to promote public understanding of the causes of, health impacts of, and resilient responses to large and severe wildfires. The exhibition will focus on current research in environmental and forest health, include diverse voices from communities directly and indirectly impacted by wildfire, and reach a national audience of family visitors at museums with a special emphasis on youth underrepresented in STEM ages 11–17. The project will draw direct connections between human health and healthy forests and promote collective strategies to mitigate and adapt to wildfires in support of positive health outcomes.

PI_NAMEs: COATS, VICTORIA JEAN (contact);NGUYEN, CECILIA

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Age;Award;Awareness;bilingualism;climate change;Collaborations;Communities;Development;education resources;Environmental Health;exhibitions;Exhibits;experience;Exposure to;Family;Fire - disasters;forest;Forestry;Fostering;Harm Reduction;Health;health management;Health Promotion;Human;human centered design;Human Resources;Industry;land use;Latinx;multidisciplinary;multisensory;Museums;Oregon;Outcome;Persons;Population;Process;programs;Research;resilience;response;restoration;Risk;Risk Assessment;Science;science education;science museum;Smoke;Spanish;Spanish/English;square foot;teacher;Testing;Travel;United States National Institutes of Health;Universities;Voice;web site;Wildfire;Work;Youth

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

PHR: PROJECT NARRATIVE: BEHAVIORAL NEUROSCIENCE CORE Not applicable. See Overall plan.

PI_NAMEs: PICKENS, CHARLES LEE (contact)

PROJECT_TERMS: Advisory Committees;animal care;Animal Experimentation;Animal Husbandry;animal imaging;Animal Model;Animal Technicians;Animals;Area;Award;Behavioral;Behavioral Assay;Biochemical;Biological Assay;Chemistry;Cognitive;cognitive ability;cognitive neuroscience;Collaborations;college;Committee Members;Communities;Complement;Core Facility;Coupled;Decision Making;Dedications;designer receptors exclusively activated by designer drugs;Doctor of Philosophy;Electrophysiology (science);Elements;Ensure;Environment;Equipment;extracellular;Extramural Activities;Faculty;faculty research;Fluorescence Microscopy;Funding;Goals;Grant;Growth;Health;Human;improved;Individual;innovation;Institution;Kansas;Laboratories;laboratory facility;Learning;Letters;Maintenance;member;Mentors;Microscopy;Mission;Modernization;multidisciplinary;neural circuit;Neurobiology;neuroinformatics;Neuronal Plasticity;Neurosciences;Neurosciences Research;optogenetics;Phase;programs;psychologic;Psychology;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Science;success;Techniques;Technology;tenure track;Training;training opportunity;Universities;Update

PROJECT_TITLE: Behavioral Neuroscience Research Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

PHR: PROJECT NARRATIVE: NEUROINFORMATICS CORE Not applicable. See Overall plan.

PI_NAMEs: ANDRESEN, DANIEL  (contact)

PROJECT_TERMS: analytical tool;Artificial Intelligence;artificial intelligence model;Auditory;Award;behavior measurement;Behavioral;Centers of Research Excellence;cloud based;Cognitive;cognitive ability;cognitive benefits;cognitive neuroscience;Collaborations;college;Computer Models;Core Facility;Data;data access;Data Analytics;data dissemination;data management;Data Security;data sharing;Data Storage and Retrieval;design;Development;Diffusion Magnetic Resonance Imaging;Electroencephalography;Electrophysiology (science);Engineering;Environment;Equipment;Extramural Activities;Faculty;Functional Magnetic Resonance Imaging;Funding;Future;Goals;graduate student;Grant;Growth;High Performance Computing;Ice;improved;Institution;Kansas;laboratory facility;large datasets;Learning;Machine Learning;Magnetic Resonance Imaging;Medical center;member;Mission;Modeling;Modernization;neural;Neurobiology;neuroimaging;neuroinformatics;Neuronal Plasticity;Neurosciences;Phase;programs;recruit;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Route;Secure;Services;skills;Statistical Data Interpretation;success;System;Techniques;Technology;Time;tool;Training;training opportunity;Training Support;transgenic model of alzheimer disease;Universities

PROJECT_TITLE: Neuroinformatics Research Core


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative Opioid use disorder and opioid overdose impacted many tens of thousands in the United States alone. However, the fundamental basic mechanisms by which opioids act in the brain to influence natural reward behaviors remain unknown. This proposal will isolate how endogenous opioid systems function in reward circuits within the context of natural reward seeking, providing new insight into how opioid systems natural states may be negatively impact in substance use disorders.

PI_NAMEs: ZAMORANO, CATALINA ALEJANDRA (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Ablation;abuse liability;addiction;Address;Affect;Agonist;Anatomy;Area;Behavior;Behavioral;Biosensor;Brain;calcium indicator;career;career development;chronic pain relief;Clustered Regularly Interspaced Short Palindromic Repeats;Color;Complex;conditional knockout;Consumption;COVID-19 pandemic;Death Rate;Development Plans;Disinhibition;Dopamine;dopaminergic neuron;Drug usage;Electrophysiology (science);endogenous opioids;Excision;experience;experimental study;Fiber;G-Protein-Coupled Receptors;gamma-Aminobutyric Acid;Genes;Goals;Hypothalamic structure;Image;in vivo;Individual;insight;Lateral;Learning;Ligands;Measures;Mentors;Methods;Modeling;Modernization;Molecular;Mouse Strains;mu opioid receptors;National Institute of Drug Abuse;Neurobiology;neuronal excitability;Neurons;Neuropeptides;Neuropharmacology;Nucleus Accumbens;Opioid;opioid epidemic;opioid mortality;opioid overdose;Opioid Peptide;Opioid Receptor;opioid use disorder;pain reduction;Pathway interactions;Phase;Photometry;Play;Property;Prosencephalon;receptor;Receptor Activation;Receptor Signaling;Regulation;Reporting;Research;Resolution;response;Rewards;Role;Series;Severities;Shapes;Signal Transduction;skill acquisition;Slice;Source;spatiotemporal;Substance Use Disorder;Synapses;System;Techniques;Testing;Training;training opportunity;two-photon;United States;Ventral Tegmental Area;Viral;Visualization

PROJECT_TITLE: Isolating the role of endogenous mu-opioid activity in the VTA during natural reward


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Machine Learning and Artificial Intelligence;Neurosciences

PHR: PROJECT NARRATIVE: COGNITIVE NEUROSCIENCE CORE Not applicable. See Overall plan.

PI_NAMEs: ZAKRZEWSKI  , ALEXANDRIA  (contact)

PROJECT_TERMS: Agreement;Area;Artificial Intelligence;artificial intelligence model;Award;biomedical imaging;Brain;Centers of Research Excellence;Cognitive;cognitive ability;cognitive neuroscience;cognitive process;cognitive testing;Collaborations;Communities;Complement;computing resources;Consultations;Core Facility;Coupled;Data;Data Analyses;data modeling;Data Storage and Retrieval;density;Development;Educational workshop;Electroencephalography;Equipment;Extramural Activities;Faculty;Faculty Recruitment;Foundations;Functional Magnetic Resonance Imaging;Funding;Future;Goals;Grant;Hospitals;imaging facilities;improved;independent component analysis;Institution;interest;Kansas;laboratory facility;Lesion;Machine Learning;Magnetic Resonance Imaging;Manufacturer;Medical center;member;Mission;MRI Scans;neural;Neurobiology;neuroimaging;neuroinformatics;Neuronal Plasticity;neuroregulation;North Dakota;novel;outreach;Phase;Positioning Attribute;Process;programs;psychologic;recruit;repetitive transcranial magnetic stimulation;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Role;Science;source localization;success;Techniques;Technology;tenure track;Testing;tool;Training;training opportunity;Transcranial magnetic stimulation;Universities;virtual;Visit;visual neuroscience;wireless

PROJECT_TITLE: Cognitive Neuroscience Core


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Chronic Pain;Clinical Research;Complementary and Integrative Health;Mental Health;Neurosciences;Pain Research

ORG_CITY: LA JOLLA

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative The proposed training activities will investigate the overlapping and distinct psychological and neural mechanisms engaged by mindfulness meditation to induce pain and stress relief. This research will contribute to the optimization of mindfulness meditation as a pain and stress management intervention option for millions of people suffering from these ailments worldwide. My work on this project will equip me with a skillset that fully prepares me for a career as an independent cognitive neuroscientist at a research-focused academic institution, studying complementary approaches to treating pain and comorbid health conditions.

PI_NAMEs: DEAN, JON GREGORY (contact)

PROGRAM_OFFICER_NAME: QUINLAN, ERIN BURKE

PROJECT_TERMS: Absence of pain sensation;Affect;Affective;American;Amygdaloid structure;analog;Anatomy;Anterior;Anxiety;Anxiety Disorders;Area;Arousal;Attenuated;Awareness;Behavioral;blood oxygen level dependent;Books;Brain;Brain region;career;career development;chronic pain;chronic pain patient;chronic painful condition;Chronic stress;cingulate cortex;Clinical;Clinical Trials;Cognitive;comorbidity;Computational Technique;cost effective;Data;Data Set;Development;Diagnosis;economic impact;Emotional;Ethics;Event;Exhibits;Exposure to;Fostering;Functional Magnetic Resonance Imaging;Health;healthy volunteer;Human;imaging study;Individual;insight;Institution;interest;Intervention;Knowledge;Laboratories;Machine Learning;Meditation;Mentors;Mentorship;Methods;mindfulness;mindfulness meditation;Mindfulness Training;negative affect;neural;Neuroanatomy;neuroimaging;Neurologic;neuromechanism;Nociception;novel;Pain;Pain Free;Pain intensity;Pain management;pain reduction;pain relief;Participant;Pattern;Perfusion;Persons;Placebos;predictive signature;Procedures;Process;Prosencephalon;psychologic;Psychophysics;Psychophysiology;Regulation;Research;Residual state;response;Scanning;Sensory;Series;skills;somatosensory;statistics;Stimulus;Stress;stress disorder;stress management;stress reduction;Structure;System;Techniques;Testing;Time;Training;Training Activity;Training Technics;Visual;Work

PROJECT_TITLE: Brain Mechanisms Supporting Mindfulness Meditation-Induced Pain and Stress Relief


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE One of the most well-known hallmarks of human aging is cellular senescence; however the relationship between senescence and Alzheimer’s Disease (AD) is poorly understood. We hypothesize that soluble amyloids, but not fibrils or plaques, link the induction of cellular senescence in brain cells to neurodegeneration, yet it remains unclear which soluble amyloids modulate these behaviors. In order to test this hypothesis, we will utilize a combination of genetic and epigenetic measurements to compare the ability of synthetic and patient-derived amyloids to induce senescence in brain cells, thereby deducing the molecular and epigenetic overlap between senescence and AD.

PI_NAMEs: MIRANKER, ANDREW D. (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: abeta oligomer;Adipocytes;Affect;Age;age related;age-related disease;Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid;Astrocytes;ATAC-seq;Automobile Driving;Autopsy;Behavior;Binding;Biological Assay;Biological Markers;biological systems;Biology;biomarker development;biophysical techniques;Biophysics;Brain;brain cell;Brain region;Cell Aging;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Central Nervous System;Characteristics;Chemicals;Coupled;Data;Development;Disease;Disparate;DNA Methylation;Endothelial Cells;Environment;Epigenetic Process;Exhibits;Experimental Models;experimental study;Exposure to;Fatty Acids;Fibroblasts;gene network;Genetic;Genetic Transcription;Genomic Instability;Grant;hallmarks of aging;Human;human tissue;Hydrogen Peroxide;In Vitro;in vivo;Inflammatory;Ionizing radiation;irradiation;Link;Lipids;Machine Learning;Measurement;Measures;Membrane Proteins;Mesenchymal Stem Cells;Microglia;Modeling;Molecular;molecular modeling;molecular phenotype;Molecular Profiling;Nerve Degeneration;Nervous System Disorder;Neuroglia;neuroinflammation;Neurologic;neuropathology;novel;novel marker;oligodendrocyte progenitor;Oncogene Activation;Organism;Pathogenesis;Pathologic;Pathway Analysis;Patients;Peripheral;Phenotype;Physiological;Play;Radiation;reconstitution;Regional Disease;response;Role;Sampling;senescence;senescence associated secretory phenotype;senescent cell;Severity of illness;Signal Transduction;simulation;single cell ATAC-seq;single-cell RNA sequencing;Slice;Solubility;stem cells;stressor;tau Proteins;Techniques;Telomere Shortening;Testing;Therapeutic;therapeutic target;Tissues;Validation

PROJECT_TITLE: AMYLOIDOGENIC INDUCTION OF CELLULAR SENESCENCE IN ALZHEIMER'S DISEASE

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-A(50)R]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease;Health Services;Infectious Diseases;Patient Safety;Prevention;Primary Health Care

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative There is a great need to improve the quality of dental care delivered to patients. Currently, dentistry does not have broadly accepted quality measures that inform the need for improvements in care. In this project we seek to first understand the reasons for suboptimal performance with regard to caries management at four large dental institutions, and then develop and evaluate system-level approaches to improve the quality of caries management.

PI_NAMEs: KALENDERIAN, ELSBETH ;WALJI, MUHAMMAD  (contact)

PROGRAM_OFFICER_NAME: ELWOOD, WILLIAM N

PROJECT_TERMS: Academic Medical Centers;Adopted;Adult;arm;Award;California;Caring;Child;Clinic;clinical decision support;conduct problem;cost;dashboard;Data;Data Scientist;Dental;Dental Care;Dental caries;Dental Clinics;Dental General Practice;Dentistry;Dentists;design;Diagnosis;Effectiveness;efficacy study;Electronic Health Record;Elements;Engineering;Epidemiologist;evidence base;Feedback;Future;Goals;Group Practice;Health;health care delivery;Health Sciences;Health system;Healthcare;Human;human centered design;improved;Informatics;informatics infrastructure;insight;Institution;Intervention;Interview;Investments;Knowledge;Learning;Measurement;Measures;multi-component intervention;multidisciplinary;Oral;Oral health;Outcome;patient safety;Patient-Focused Outcomes;Patients;Performance;person centered;Phase;prevent;Provider;Publications;Quality of Care;Research;San Francisco;Science;sealant;Site;Specialist;Support System;System;Texas;Time;Universities;Work

PROJECT_TITLE: Implementing Dental Quality Measures in Practice

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]