NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Genetics;Heart Disease;Pediatric;Pediatric Cardiomyopathy;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE: The research included in this proposal will improve our understanding of disease mechanisms that contribute to the health burden of hypertrophic cardiomyopathy and heart failure. Studying multiple mutations with divergent effects on molecular function and developing quantitative modeling tools to predict resultant changes in molecular and cellular force generation and cellular remodeling will set the stage for a more precise categorization of and search for new individualized therapeutics for patients with different HCM genotypes. Finally, advanced knowledge on the effects of altered forces on cardiac fibroblast phenotype and extracellular remodeling will provide greater insight into the role of secondary tissue remodeling (fibrosis) that contributes to HCM disease progression.

PI_NAMEs: VANDER ROEST, ALISON SCHROER (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Adhesions;Advisory Committees;Affect;Alleles;Area;ATP phosphohydrolase;Automobile Driving;Award;beta-Myosin;Biological Models;Biomechanics;Biomedical Engineering;Cardiac;Cardiac Myocytes;career;career development;Categories;Cell Adhesion;Cell-Cell Adhesion;Cells;Cellular biology;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Computer Models;Contracts;CRISPR/Cas technology;Cues;Development;Disease;disease phenotype;Disease Progression;disease-causing mutation;Elements;Engineering;Environment;Event;experience;extracellular;Extracellular Matrix;Fibroblasts;Fibrosis;Fluorescence Resonance Energy Transfer;Functional disorder;Gene Expression;Generations;Genes;Genotype;Goals;Health;Heart;Heart Diseases;Heart failure;Heritability;Heterogeneity;Human;human induced pluripotent stem cells;Hypertrophic Cardiomyopathy;Hypertrophy;improved;in silico;In Vitro;in vivo;individualized medicine;Induced Mutation;induced pluripotent stem cell derived cardiomyocytes;innovation;insight;Integrins;Intercellular Junctions;ITGB3 gene;Kinetics;Knowledge;Lead;Link;MAP Kinase Gene;Measurement;Measures;Mechanics;Mediator;Mentors;Mentorship;Modeling;Molecular;Molecular Biology;molecular phenotype;mutant;Mutation;Myofibrils;Myofibroblast;Myosin ATPase;Myosin Heavy Chains;new therapeutic target;novel;Organ;Pathologic;Pathway interactions;Patients;Pattern;personalized therapeutic;Pharmacotherapy;Phase;Phenotype;Point Mutation;Positioning Attribute;Production;Proteins;Regulation;Relaxation;Research;research and development;Research Support;response;Role;Sarcomeres;sensor;Severity of illness;Signal Pathway;Signal Transduction;single molecule;skill acquisition;skills;species difference;System;Technical Expertise;Techniques;Testing;Tissues;tool;Traction Force Microscopy;Training;transcriptome;transcriptome sequencing;transcriptomics;Universities;Validation;Variant;Vinculin

PROJECT_TITLE: Modeling myosin mechanobiology towards understanding the mechanisms of hypertrophic cardiomyopathy

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: DC

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Hearing Loss;Rehabilitation;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative: Enormous unexplained differences in speech recognition outcomes are observed for both newly implanted and experienced adult cochlear implant (CI) users. This project aims to determine how specific attributes of the auditory-social environment impact speech recognition abilities in new CI users, and how their environments change following implantation. Findings will identify factors that are potentially modifiable and reflect the everyday, real-world experience of adult CI users, setting the groundwork for accounting for them in clinical settings.

PI_NAMEs: TAMATI, TERRIN NICHOLE (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Accounting;Address;Adult;Audiology;Auditory;Categories;Clinical;Clinical Assessment Tool;Cochlear implant procedure;Cochlear Implants;Cognitive;Communication;Comprehension;Cues;deafness;Development;effective therapy;Environment;experience;Face;Fatigue;Future;Goals;Implant;implantation;improved;Individual Differences;interdisciplinary approach;Knowledge;Lead;Learning;Linguistics;Maps;Measures;Methods;normal hearing;novel;Operative Surgical Procedures;Outcome;Participant;Patients;Perception;Perceptual learning;Phonetics;phonology;Play;Process;Protocols documentation;Psycholinguistics;Rehabilitation therapy;Research;Role;Sensorineural Hearing Loss;Sensory;sensory input;Signal Transduction;skills;social;social communication;social engagement;Social Environment;Social Functioning;Social Network;Specific qualifier value;Speech;speech recognition;Speech Sound;success;Techniques;Testing

PROJECT_TITLE: Beyond Clinical Measures:  Auditory-Social Experience and Robust Communication Skills in Adults Following Cochlear Implantation

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Data Science;Health Services;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Pulmonary Hypertension;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Heart failure imposes a tremendous morbidity and mortality burden, costing the U.S. healthcare system over $31 billion per year. An under-recognized and yet important contributor to heart failure outcomes is right ventricular dysfunction, which remains understudied due to technical issues that have historically challenged conventional approaches to cardiovascular imaging. We will examine how deep learning models can precisely evaluate right ventricular function – and enable earlier, more accurate assessments of its contributions to cardiovascular risk.

PI_NAMEs: OUYANG, DAVID  (contact)

PROGRAM_OFFICER_NAME: SHANBHAG, SUJATA MADHUKAR

PROJECT_TERMS: Address;Advisory Committees;Architecture;Arrhythmogenic Right Ventricular Dysplasia;automated assessment;Award;Cardiovascular Diseases;cardiovascular imaging;cardiovascular risk factor;Cardiovascular system;career;career development;Categories;Cause of Death;Cessation of life;Characteristics;Classification;Clinical;cohort;Communities;community based care;computer science;Computer Vision Systems;Coronary Arteriosclerosis;cost;Data;Data Science;Data Set;deep learning;deep learning algorithm;deep learning model;deep neural network;Derivation procedure;design;Diagnosis;Disease;Disease Outcome;Dissection;Early Diagnosis;Echocardiography;Engineering;Epidemiology;Etiology;Evaluation;Framingham Heart Study;Future;Goals;hands on research;Health system;Healthcare;healthcare community;Healthcare Systems;Heart failure;heart imaging;Heterogeneity;Hospitals;Human;Image;image translation;imaging science;improved;Incidence;Learning;Machine Learning;Maps;Measures;Medical Imaging;Medicine;Mentors;Modeling;Morbidity - disease rate;Morphology;mortality;Motion;Multi-Ethnic Study of Atherosclerosis;Nature;neural network;neural network architecture;novel;Outcome;outcome prediction;Participant;Patients;Pattern;Performance;performance tests;Phase;Phenotype;Physicians;population based;predictive modeling;Prognosis;prognostic;Program Development;programs;Prospective cohort;public health relevance;pulmonary arterial hypertension;Pulmonary Embolism;Research;Research Personnel;Right Ventricular Dysfunction;Right Ventricular Function;Right ventricular structure;Risk;Risk Factors;Sampling;Scientist;Semantics;skills;spatiotemporal;Standardization;statistics;Stroke;study population;success;Techniques;temporal measurement;Training;Translational Research;United States;Validation;Variant;Ventricular

PROJECT_TITLE: Deep Learning Assessment of the Right Ventricle: Function, Etiology, and Prognosis


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: BATON ROUGE

ORG_DEPT: BIOLOGY

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: PROJECT NARRATIVE The function and regulation of mammalian RNAi machinery in the context of antiviral immunity has remained poorly understood mainly because the RNAi machinery in mammals also regulates basic cellular function, making it impossible to manipulate the RNAi gene expression without causing developmental defects or lethality. We have recently succeeded in uncoupling human RNAi’s functions in antiviral immunity and in development by re-producing the antiviral activity of human RNAi machinery in Caenorhabditis elegans nematodes. Findings from the proposed research will not only advance our understanding on how the antiviral activity of human RNAi machinery is regulated but also facilitate the development of novel therapeutic strategy for treatment of viral infection.

PI_NAMEs: LU, RUI  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: 2019-nCoV;Affinity;Anti-viral Agents;antiviral immunity;Binding;Biogenesis;Caenorhabditis elegans;Cell Differentiation process;Cell division;cell growth;Cell Physiology;Defect;Development;DNA Sequence Alteration;Double-Stranded RNA;ds RNA-Binding Proteins;emerging virus;FBXW7 gene;fungus;Gene Expression;Genes;Genome;Human;Human Activities;improved;In Vitro;in vivo;Infection;Infection prevention;insight;Invertebrates;knockout gene;Mammals;Mediating;MicroRNAs;Molecular;Mus;NCOA6 gene;Nematoda;Newborn Infant;novel therapeutic intervention;Physiological;Plants;Process;Production;Proteins;reconstitution;recruit;Regulation;Research;RNA Interference;RNA Viruses;Small Interfering RNA;stem cells;Structure;Therapeutic;Transcript;Transgenes;treatment strategy;Viral;Viral Load result;Viral Physiology;viral RNA;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Negative regulation of human antiviral RNAi by PACT


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: BALTIMORE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Establishing how combinations of broadly HIV-neutralizing antibodies (bnAbs) with different epitope specificities can be most effectively used to cover HIV variants would have significant impact on the development of approaches to prevent or treat HIV infection. This project will uniquely focus on, and determine, the reactivity of single virions with multiple bnAb classes in situ. The data will fill key information gaps in the process of deciding how to best use bnAb combinations for HIV prevention and therapy.

PI_NAMEs: RAY, KRISHANU  (contact)

PROGRAM_OFFICER_NAME: ZHOU, YAN

PROJECT_TERMS: AIDS prevention;Animal Model;Anti-Retroviral Agents;Anti-viral Agents;Antibodies;Antibody Therapy;Apical;Binding;Binding Sites;Biological Assay;Classification;Clinical;clinical development;Clinical Trials;Data;Detection;detection method;Development;Disease;Engineering;Epitopes;Exhibits;exosome;experience;experimental study;Fluorescence;Fluorescence Resonance Energy Transfer;Future;Goals;HIV;HIV envelope protein;HIV Infections;HIV therapy;HIV/AIDS;immunoreactivity;In Situ;In Vitro;in vivo;indexing;Individual;Infection;innovation;Intervention;Lead;Mannose;Measures;Mediating;member;Methods;Modeling;neutralizing antibody;novel;Outcome;particle;Pattern;Persons;Pharmaceutical Preparations;Pharmacotherapy;Plasma;Play;Population;pre-clinical;preclinical study;prevent;Prevention;Prevention trial;Process;Resistance;Role;Sampling;screening;single molecule;Specificity;Spectrum Analysis;Standardization;Surface;System;Techniques;Testing;Therapy trial;tool;transmission process;Variant;viral rebound;Viremia;Virion;Virus

PROJECT_TITLE: Broadly neutralizing antibody combinations with single virions in HIV+ plasma

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: SAINT LOUIS

ORG_DEPT: GENETICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative This project will directly address a persistent puzzle in developmental gene regulation: how do newly active developmental transcription factors bind and activate their target enhancers, when they are tightly wrapped by nucleosomes that prevent transcription factor binding in the first place? The experiments proposed to solve this puzzle will not only leverage cutting edge molecular technologies to probe the dynamics of transcription factor- chromatin conflicts, but will also probe whether there are biological rationales for the persistence of these conflicts, such as for the maintenance of developmental fidelity across variable metabolic contexts that are commonly experienced in vivo. In summary, the proposed project will improve our understanding of the function of chromatin as a regulator of cell fate that can be applied across myriad developmental and disease contexts, and will integrate this understanding of molecular regulation with our broader understanding of cellular metabolic state.

PI_NAMEs: MEERS, MICHAEL P (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Acetyl Coenzyme A;Address;Award;Base Pairing;Binding;Biological;Biological Models;Buffers;career;Cell Differentiation process;Cell Fate Control;cell fate specification;cell type;Cells;Chromatin;Chromatin Structure;Consumption;Development;Developmental Gene;Disease;Disparity;DNA;DNA Binding;DNA Sequence;Downstream Enhancer;Educational Status;embryonic stem cell;Enhancers;Ensure;Environment;epigenomic profiling;epigenomics;Equilibrium;Event;Excision;expectation;experience;experimental study;forging;Foundations;Future;Gene Expression;Gene Expression Regulation;Genes;Genetic Enhancer Element;genetic manipulation;Genetic Transcription;Genome;Heterogeneity;Histones;Hypoxia;Image;improved;in vivo;innovation;insight;Maintenance;Malignant Neoplasms;Measures;Metabolic;Metabolic Control;Metabolism;metabolomics;Methods;Modeling;Molecular;Mutation;novel;Nucleosomes;Outcome;Oxygen;Phase;Play;Pluripotent Stem Cells;prevent;Process;programs;Regulation;Research;Resolution;response;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;screening;Site;Specific qualifier value;stem cell differentiation;stem cells;Structure;System;Techniques;Technology;Testing;theories;Time;Training;transcription factor;Variant

PROJECT_TITLE: Molecular impediments to fate-specifying pioneer factor activity during development


NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Lung;Pediatric;Pneumonia;Pneumonia and Influenza

ORG_CITY: GALVESTON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Respiratory syncytial virus (RSV) is associated with bronchiolitis, pneumonia and flu-like syndromes, as well as asthma exacerbations, and it is considered a serious public health problem, for which no effective treatment or vaccine is currently available, while many fundamental questions regarding the pathogenesis of its associated lung disease still need to be answered. This project seeks to investigate novel molecular mechanisms regulating host cell responses following infection with RSV. In the long term, our studies could lead to new pharmacologic strategies to prevent or treat serious lower respiratory tract infections, therefore reducing RSV- associated morbidity and mortality.

PI_NAMEs: CASOLA, ANTONELLA  (contact)

PROGRAM_OFFICER_NAME: KIM, SONNIE

PROJECT_TERMS: Acute;Affect;Airway Disease;airway epithelium;Animals;antagonist;asthma exacerbation;Aubergine;Autoimmune Diseases;Bacterial Pneumonia;Biogenesis;Biological Process;Bronchiolitis;cancer type;Candidate Disease Gene;Cardiovascular Diseases;Categories;Cell Physiology;Cell Separation;cell type;Cells;Cessation of life;Child;circular RNA;Clinical;Complex;Conserved Sequence;Cytoplasm;Defense Mechanisms;Developing Countries;Disease;disease diagnosis;disease prognosis;DNA;effective therapy;Elderly;Epigenetic Process;epigenetic regulation;Epithelial Cells;exosome;Family;flu;Gene Expression;Gene Expression Regulation;Gene Targeting;Generations;genetic element;Genetic Transcription;Germ Cells;gonad development;Homologous Gene;Host Defense;Human;Immune;Immune response;Immunity;Immunocompromised Host;Infection;Inflammatory Response;information gathering;Innate Immune Response;Investigation;Knowledge;Licensing;Life;Link;Literature;Location;loss of function;Lower Respiratory Tract Infection;Lung;Lung Diseases;member;Messenger RNA;Methods;MicroRNAs;Modeling;Molecular;Molecular Target;Morbidity - disease rate;mortality;mouse model;Mus;Neurodegenerative Disorders;new therapeutic target;novel;Nuclear;older patient;Organ;Organelles;Other Genetics;Outcome;pathogen;Pathogenesis;Pathway interactions;Pattern;pediatric patients;pharmacologic;physical property;piRNA;Play;Pneumonia;prevent;Property;protein complex;Proteins;Public Health;respiratory morbidity;respiratory pathogen;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Respiratory Syncytial Virus Vaccines;Respiratory Tract Infections;response;Retrotransposon;RNA;RNA analysis;RNA Binding;RNA Interference;Role;Signal Transduction;Small Interfering RNA;Small Nucleolar RNA;Small RNA;Somatic Cell;Spermatogenesis;Subcellular structure;Syndrome;Testing;Therapeutic;therapeutic biomarker;therapeutic target;Transcriptional Regulation;transcriptome;Untranslated RNA;Vaccines;Viral;Virus;Virus Diseases;virus host interaction;Virus Replication

PROJECT_TITLE: PIWIL4 and piRNAs in RSV Infection


NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Brain Disorders;Complementary and Integrative Health;Multiple Sclerosis;Neurodegenerative;Neurosciences;Precision Medicine

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Public Health Relevance Statement (Project Narrative) The proposed research will validate a new metabolic imaging approach allowing for non-invasive assessment of oxidative stress in Multiple Sclerosis (MS). Upon clinical translation, the methods developed in this proposal will serve to ameliorate clinical management of MS patients, help refine therapeutic regimens and, ultimately, lead to better outcome and patient quality of life.

PI_NAMEs: CHAUMEIL, MYRIAM MARIANNE (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Acetates;Acetylcysteine;Adoption;Affect;alternative treatment;Alzheimer's Disease;Amino Acids;Antioxidants;Ascorbic Acid;Autopsy;Biological Assay;Biopsy;Brain;Cancer Model;Caring;Cerebrum;Clinical;Clinical Management;clinical practice;clinical translation;clinically relevant;cognitive function;Cysteine;data quality;Detection;detection method;Diabetes Mellitus;Disease Progression;Disease remission;effective therapy;Etiology;Evaluation;Fumarates;glucose metabolism;Glutathione;Homeostasis;Image;imaging approach;Imaging Device;imaging modality;Immunohistochemistry;immunomodulatory therapies;improved;in vivo;in vivo imaging;Inflammation;Inflammatory;Injections;Injury to Kidney;innovation;Lead;Lesion;Light;Link;Magnetic Resonance Imaging;magnetic resonance spectroscopic imaging;Measures;Metabolic;metabolic imaging;Metabolism;Methods;Monitor;multimodality;Multiple Sclerosis;multiple sclerosis patient;Mus;Nervous System Disorder;Neurologic;Noise;Non-Invasive Detection;novel;Organ;Outcome;Oxidation-Reduction;Oxidative Stress;Oxidative Stress Pathway;Pancreas;Parkinson Disease;patient population;Patients;Penetration;Peripheral;personalized therapeutic;Persons;Play;Population;Pre-Clinical Model;precision medicine;Process;Production;Prognostic Marker;public health relevance;Quality of life;Reaction;Reactive Oxygen Species;Regimen;Relapse;Relapsing-Remitting Multiple Sclerosis;Reporting;Research;Resolution;respiratory;Role;Scheme;Secondary Progressive Multiple Sclerosis;Signal Transduction;Structure;targeted biomarker;targeted treatment;Techniques;Testing;theranostics;Therapeutic;Tissues;tool;Toxic effect;translational potential;treatment response;treatment strategy;Validation

PROJECT_TITLE: Theranostic Metabolic Imaging of Oxidative Stress in Multiple Sclerosis.

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: PHYSIOLOGY

PHR: RELEVANCE (See instructions): Altered sensory processing is the hallmark of most psychiatric conditions, from schizophrenia to autism,  but to this date, it remains unknown how sensory information is processed in the brain and to which extend  perception is influenced by our emotional state. By studying how visual information is integrated and  shaped by internal factors, this project will increase our understanding of the fundamental processing  underlying healthy sensory experience. The outcomes of this project will shed the light on new approaches  and paradigms to investigate pathological conditions.

PI_NAMEs: SAVIER, ELISE L (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Anatomy;Animal Model;Animals;Area;area striata;Arousal;Attention;autism spectrum disorder;Behavior;Behavioral;behavioral study;Brain;Brain region;Calcium;cell motility;cell type;Cells;comparative;Dorsal;Electrophysiology (science);Emotional;Evolution;experience;experimental study;Genetic;Goals;House mice;Image;Instruction;Label;Lateral Geniculate Body;Locomotion;Methods;Midbrain structure;Modality;Molecular;Morphology;Motion;Mus;Neurons;novel strategies;optogenetics;Outcome;Pathologic;Pathway interactions;Pattern;Perception;Phase;Population;Positioning Attribute;preference;Primates;Process;Property;Pulvinar structure;Reporting;Research;Research Personnel;response;Retina;Sampling;Schizophrenia;Sensory;sensory input;Shapes;Source;Stream;Structure;superior colliculus Corpora quadrigemina;System;Testing;Thalamic structure;tool;Tupaia;Tupaiidae;Viral;Vision;Visual;Visual Cortex;Visual Fields;visual information;Visual Pathways;Visual System;Work

PROJECT_TITLE: Integration of visual information and behavioral modulation in the superior colliculus


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: Molecular Biophysics seeks to define the basic underpinning of health and disease by obtaining a quantitative description of the shapes and surface features of molecules, and the network of interactions between the many thousands of molecules that bring cells to life. Our training program provides a highly enriching environment for educating scientists in the language and implementation of Molecular Biophysics so that it can be applied to the most critical questions in medicine and biology. By fostering the development of a cadre of diverse and highly-skilled quantitative scientists, our program will contribute in a significant way to understanding human physiology and the malfunctions that lead to disease, which in turn can be used to develop new approaches and technologies to address the critical challenges at the forefront of biomedical science.

PI_NAMEs: CHAZIN, WALTER J. (contact);JACKSON, LAUREN PARKER;LACY, DANA BORDEN

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TERMS: Biophysics;Grant;Molecular;Training

PROJECT_TITLE: Molecular Biophysics Training Grant at Vanderbilt

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Clinical Research;Hematology

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Hematology Research Training Program (T32 HL-07439) PI/PD: Brass, Lawrence F. Narrative As the pace at which biomedical research advances increases, there is a greater need than ever for physician- scientists and scientists who are trained to work at the intersection between medicine and science. The goal of the Hematology Research Training Program is to identify, train and mentor a diverse group of outstanding men and women and to help them become teachers, scholars, and leaders of biomedical research in academia, industry with an emphasis on fields of endeavor that are applicable to the broad range of hematology.

PI_NAMEs: BRASS, LAWRENCE F (contact);MAILLARD, IVAN

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TITLE: Hematology Clinical Research Training Program

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM (OA)]


NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: BIOPHYSICS

PHR: PROJECT NARRATIVE The proposed research is relevant to human health because cells sense changes in their environment through signaling processes that occur at the plasma membrane which defines the cell surface. This work seeks to decipher how heterogeneous membranes fundamentally contribute to cell sensing in broad functional contexts, with the ultimate goal of providing researchers with novel strategies for the treatment of disease. The proposed research is relevant to the part of NIH’s mission that pertains to seeking fundamental knowledge that will help to prevent and treat these human illnesses.

PI_NAMEs: VEATCH, SARAH L (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Actins;Adaptor Signaling Protein;Allosteric Regulation;Behavior;Biochemical;Biochemistry;Brain;Cell membrane;Cell Physiology;Cell surface;cell type;Cells;Chemicals;Defect;Disease;Environment;Extracellular Space;fluorescence imaging;functional outcomes;Future;Goals;Health;Homeostasis;Human;human disease;Hydrophobicity;Immune;immunodeficiency;Individual;Inhibitory Synapse;Ion Channel;Knowledge;Lead;Lipids;Liquid substance;Malignant Neoplasms;Membrane;Methods;Mission;Modeling;Nerve Degeneration;Neurons;novel strategies;novel therapeutic intervention;Nuclear Envelope;Outcome;pathogen;Phase Transition;Predisposition;prevent;Process;programs;Proliferating;Property;Proteins;receptor;Research;Research Personnel;response;Role;Scaffolding Protein;Shapes;Signal Transduction;single molecule;Stimulus;System;Thermodynamics;transmission process;treatment strategy;United States National Institutes of Health;Vision;Work

PROJECT_TITLE: Functional Roles of the Membrane Phase Transition in Cellular Physiology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-R (55)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: DETROIT

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: Project Narrative/Relevance—Overall Program The identification of genetic contributors to cancer will help identify high-risk groups and support the development of new treatments, as well as refine prevention and screening guidelines. However, even with our current knowledge of susceptibility genes and the expected novel discoveries, there are significant barriers to getting genetic counseling and testing, particularly in the African American population. Until we can overcome these barriers, the implementation of clinical testing will be difficult, therefore the development of novel strategies to overcome barriers to testing will be essential in reducing cancer burden and health disparities.

PI_NAMEs: BEEBE-DIMMER, JENNIFER L;SCHWARTZ, ANN G. (contact)

PROGRAM_OFFICER_NAME: FILIPSKI, KELLY

PROJECT_TERMS: Address;African American;African American population;Age;Automobile Driving;barrier to testing;Bioinformatics;Biology;Cancer Burden;cancer diagnosis;cancer genetics;cancer health disparity;cancer prevention;cancer risk;Cancer Survivor;cancer type;Cancer-Predisposing Gene;carcinogenesis;Classification;clinical implementation;Clinical Management;clinical practice;cohort;Colorectal Cancer;community engagement;Community Outreach;cost;Data;Death Rate;Decision Making;Development;Diagnosis;Disparity;E-learning;Early Diagnosis;Early treatment;Educational Intervention;Endometrial Carcinoma;exome;Family Cancer History;family structure;Family Study;Gene Expression;Genetic;Genetic Counseling;Genetic Predisposition to Disease;Genetic Research;Genetic Risk;Genetic study;genetic testing;genetic variant;Genetic Variation;Genomics;Germ Lines;Germ-Line Mutation;Goals;health disparity;high risk;high risk population;improved;Incidence;Individual;Infrastructure;Inherited;Intervention;Knowledge;Learning;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;medically underserved;metropolitan;Minority Groups;modifiable risk;mortality;Mutation;non-genetic;Not Hispanic or Latino;novel;novel strategies;novel therapeutic intervention;Outcome;Participant;Pathogenicity;Pathway interactions;Penetrance;polygenic risk score;Population;population based;Prevention;Prevention Guidelines;Probability;programs;Race;Research;research clinical testing;Risk;Risk Factors;Role;Science;screening;screening guidelines;Second Primary Cancers;Site;Somatic Mutation;Surveys;Susceptibility Gene;System;Target Populations;testing services;Translating;Underrepresented Populations;Underserved Population;uptake;Variant;variant of unknown significance

PROJECT_TITLE: Genetic Variation in Cancer Risk and Outcomes in African Americans

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RPRB-6 (O1)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research

PHR: Project Narrative Variants of uncertain significance (VUS) in known cancer susceptibility genes are more commonly identified in African Americans compared to whites, and there is a need for innovative approaches to characterizing potentially clinically actionable VUS. Identifying novel pathogenic mutations in known cancer susceptibility genes will improve our ability to provide targeted prevention and treatment options for African Americans with hereditary cancers, and defining the genomic landscape of cancer susceptibility in African Americans will improve identification of high-risk individuals who would benefit from enhanced surveillance and precision treatments.

PI_NAMEs: PURRINGTON, KRISTEN S. (contact)

PROJECT_TERMS: actionable mutation;Affect;African American;African American population;Age;Age of Onset;Alleles;Breast;Cancer Detection;cancer genetics;cancer health disparity;Cancer Prevention Intervention;cancer risk;Cancer Survivor;cancer therapy;Cancer-Predisposing Gene;Catchment Area;Categories;Characteristics;Classification;Clinical;clinically actionable;cohort;Collaborations;Colorectal;Colorectal Neoplasms;cost;Data;Diagnosis;Disease;DNA Repair Gene;DNA Repair Pathway;Early Diagnosis;Endometrial;Epidemiology;European ancestry;Evaluation;Exclusion;exome sequencing;Family;Family Cancer History;Family member;Gene Expression;gene panel;gene repair;Genes;Genetic;genetic architecture;Genetic Counseling;Genetic Databases;genetic panel test;Genetic Predisposition to Disease;genetic testing;genetic variant;Genetic Variation;Genomics;Germ Lines;Germ-Line Mutation;Goals;Guidelines;Hereditary Malignant Neoplasm;Hereditary Neoplastic Syndromes;Heritability;high risk population;homologous recombination;improved;in silico;In Vitro;in vivo;Incidence;Individual;Inherited;innovation;interest;International;machine learning classifier;Malignant Neoplasms;Mammary Neoplasms;Medical Genetics;meetings;metropolitan;Mismatch Repair;Modeling;Molecular Biology Techniques;Molecular Profiling;mRNA sequencing;Mutate;Mutation;National Comprehensive Cancer Network;new technology;novel;Outcome;Participant;Pathogenicity;Patients;Pattern;Population;Population Database;Population Sciences;Population Study;Precision therapeutics;predictive modeling;Predisposition;Prevalence;Prevention;Process;Prostate;protein function;psychologic;racial disparity;racial diversity;recombinational repair;Recontacts;recruit;Registries;Research;RNA;RNA analysis;segregation;Somatic Mutation;Syndrome;System;Time;tool;Training;tumor;Validation;Variant;variant of unknown significance

PROJECT_TITLE: Project 1


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Lung;Lung Cancer;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases;Women's Health Research

PHR: Project Narrative The proposed project will investigate the role of inherited genetic susceptibility as well as select environmental risk factors with the development of multiple primary cancers (MPCs) in African Americans first diagnosed with female breast, prostate or colorectal cancer. We will discover new knowledge about factors underlying MPCs in African Americans, a population experiencing excess cancer morbidity and mortality. This information will inform future screening, prevention, and risk-mitigation strategies and ultimately lessen the cancer burden in this high risk population.

PI_NAMEs: BEEBE-DIMMER, JENNIFER L (contact)

PROJECT_TERMS: Address;African American population;Alcohol consumption;Baseline Surveys;Biological Factors;Blood;breast cancer survival;Cancer Burden;cancer diagnosis;cancer genetics;cancer predisposition;cancer risk;cancer site;Cancer Survivor;cancer type;Cancer-Predisposing Gene;Cessation of life;Characteristics;cohort;Colorectal Cancer;comorbidity;Consent;Data;Death Rate;design;Detection;Development;Diagnosis;Disparate;DNA;DNA Sequence;DNA sequencing;Early Diagnosis;Endometrial Carcinoma;Enrollment;Environmental Risk Factor;Ethnic Population;exome sequencing;experience;Face;Female Breast Carcinoma;Frequencies;Future;General Population;Genes;Genetic;Genetic Predisposition to Disease;Genetic study;genetic variant;Genetic Variation;Genome;genome-wide;Genotype;Germ Lines;high risk population;improved;Incidence;Infrastructure;Inherited;Investigation;Knowledge;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;Medical Records;Morbidity - disease rate;mortality;multi-ethnic;Mutation;non-genetic;Not Hispanic or Latino;novel;Obesity;Outcome;Participant;Pathogenicity;Phenotype;polygenic risk score;Population;Population Heterogeneity;Prevalence;Prevention;Prostate;Race;racial disparity;racial diversity;racial population;rare variant;Research;response;Risk;Risk Factors;risk mitigation;Role;Saliva;screening;Second Primary Cancers;Smoking;SNP array;Specimen;Surveys;Survivors;Susceptibility Gene;Testing;tumor;Tumor Tissue;Update;Variant;Whole Blood

PROJECT_TITLE: Project 2


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: African Americans are more like to be diagnosed with cancers with genetic risk. Interventions that target barriers to genetic counseling and testing unique to African Americans (i.e., limited understanding of genetic information, fears about the abuse of testing results) may be helpful in making sure they get recommended testing, thereby reducing inequalities in cancer outcomes and overall survival rates for African Americans.

PI_NAMEs: HARPER, FELICITY  (contact)

PROJECT_TERMS: Access to Information;Address;Adult;African American;African American population;Behavior Therapy;Biology;Breast;Cancer Burden;cancer care;cancer health disparity;cancer risk;Cancer Survivor;carcinogenesis;clinical practice;Colorectal Cancer;Communities;community collaboration;community engaged approach;community partnership;Consultations;cost;cost effective;Death Rate;Diagnosis;Discrimination;disparity reduction;E-learning;Early Intervention;early onset;Education;Educational Intervention;Equity;experience;Face;Faith leader;Family;Fright;Future;Genetic;Genetic Counseling;genetic information;Genetic Research;Genetic Risk;genetic testing;Genetic Variation;Genomics;Goals;Health;Health Services Accessibility;Healthcare;Hereditary Neoplastic Syndromes;high risk population;implementation barriers;improved;Incidence;Inequality;Intervention;Intervention Trial;Knowledge;literacy;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;Medical Genetics;Medical Research;medically underserved;Methods;Modeling;mortality;novel;Obesity;Outcome;Phase;Population;Prevention;Printing;Prostate;racial disparity;racial health disparity;randomized trial;Recommendation;Recording of previous events;Research;Risk;screening;Services;social;social determinants;social stigma;Survival Rate;Survivors;tailored messaging;Target Populations;Test Result;Testing;therapy design;therapy development;Translating;Translations;Transportation;uptake


NIH_SPENDING_CATS: Cancer;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research

PHR: Project Narrative The Administrative Core provides the leadership and administrative infrastructure to support Program-related activities, provides fiscal and regulatory oversight, and coordinates mechanisms of feedback, evaluation, and official communication with both the NCI and the community. This Core enables scientists to focus on their research by providing efficient overall management.

PI_NAMEs: SCHWARTZ, ANN G. (contact)

PROJECT_TERMS: Address;African American population;Automobile Driving;cancer genetics;cancer risk;Cancer Science;Cancer Survivor;cohort;Communication;Communities;Comprehensive Cancer Center;Data Collection;Decision Making;Effectiveness;Ensure;Evaluation;Feedback;General Population;Genetic;genetic testing;Genetic Variation;Goals;Grant;health disparity;high risk population;improved;Infrastructure;Institution;Leadership;Malignant Neoplasms;Measures;Medical Genetics;meetings;metropolitan;Michigan;National Cancer Institute;neoplasm registry;novel;Occupational activity of managing finances;Outcome;Participant;population based;Population-Based Registry;Procedures;Program Efficiency;programs;Race;Regulation;Research;Research Institute;Research Personnel;Research Project Grants;Resource Sharing;Resources;Scientist;screening;Structure;System;systematic review;United States National Institutes of Health;Universities;uptake

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Prevention;Racial and Ethnic Minority Health Research

PHR: PROJECT NARRATIVE—Data Collection and Clinical Genetics Core The Data Collection and Clinical Genetics Core serves as a hub in support of data and biospecimen collection across multiple projects aimed at understanding the role of inherited susceptibility to cancer in African Americans and improving access to genetic counseling and testing services in this population. It also extends participation in research by providing clinical genetic testing based on research findings.

PROJECT_TERMS: actionable mutation;Address;African American;African American population;Age;Blood;cancer diagnosis;cancer health disparity;cancer risk;cancer site;Cancer Survivor;Clinical;Clinical Services;clinically actionable;Collection;Color;Colorectal Cancer;cost;cost effective;Data;data cleaning;Data Collection;data management;Development;Diagnosis;disparity reduction;DNA;Eligibility Determination;eligible participant;Endometrial Carcinoma;Enrollment;Ensure;exome sequencing;Family Cancer History;follow-up;Frequencies;Genetic;Genetic Counseling;Genetic Predisposition to Disease;genetic testing;genetic variant;Genetic Variation;Genomics;Genotype;Germ Lines;Goals;Guidelines;high risk population;Improve Access;improved;improved outcome;Institution;Intervention;Interview;Link;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Medical Genetics;meetings;metropolitan;Mutation;National Comprehensive Cancer Network;neoplasm registry;Not Hispanic or Latino;novel;Outcome;Participant;Pathogenicity;Patients;Population;population based;Population Study;Prevention Guidelines;Process;programs;Protocols documentation;Quality Control;recruit;Recurrence;Research;research clinical testing;Research Project Grants;Resource Sharing;Resources;RNA;Role;Saliva;Sampling;screening guidelines;Second Primary Cancers;Services;sharing platform;Site;Surveys;survival outcome;System;Telephone;Testing;testing services;tumor;tumor DNA;Tumor Tissue;uptake;voucher

PROJECT_TITLE: Core 1


ORG_CITY: NEW HAVEN

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: This competing renewal of our post-doctoral training grant in anesthesiology will prepare young physician scientists to become independent researchers in areas of medical science that are pertinent to the practice of anesthesiology and perioperative medicine. Areas of scientific focus include Neurobiology, Vascular Biology, Immunology, Biomechanical Engineering, and Clinical Research. Across all of these areas, our foundational mission is to train future independent scientists who will expand and apply knowledge of anesthesiology toward improving public health and well-being.

PI_NAMEs: SCHONBERGER, ROBERT  (contact)

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TERMS: Anesthesia procedures;Research Training

PROJECT_TITLE: Research Training in Anesthesia

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-A (PD)]


PHR: PROJECT NARRATIVE The University of Michigan T32 postdoctoral training program in anesthesiology will benefit public health by developing a diverse, ethical, and professional research workforce that addresses the scientific underpinnings of health problems related to surgical care, critical care, and pain management.

PI_NAMEs: BRUMMETT, CHAD M;KHETERPAL, SACHIN  (contact)

PROJECT_TERMS: Anesthesiology;Michigan;Postdoctoral Fellow;Research Training;Training Programs;Universities

PROJECT_TITLE: University of Michigan Anesthesiology Post-Doctoral Research Training Program


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Pediatric;Prevention;Social Determinants of Health;Vaccine Related

ORG_CITY: PITTSBURGH

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: NARRATIVE The goal of this project is to develop a legal dataset of vaccine consent laws for minors and to model the interplay between these laws and the spread and mortality of COVID-19, leveraging the power of nationally representative data and an agent-based simulation. The project team consists of a group of interdisciplinary researchers and community partners, allowing for a rigorous understanding of the impact of vaccine consent laws and the implications of potential interventions to increase vaccine update in adolescents. We will use an agent-based simulation to model the effects of vaccine consent laws and other real-world effects (e.g., vaccine hesitancy rates) in different locations to provide researchers with valuable information to inform future policy decisions and intervention development and implementation.

PI_NAMEs: CHU, KAR-HAI  (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: 17 year old;Adolescent;adolescent health;assessment application;Authorization documentation;Awareness;Behavior;Caring;Censuses;Cities;Communicable Diseases;Communities;community based participatory approach;community collaboration;community engaged intervention;community engagement;community partners;Computer Models;Consent;Country;COVID-19;COVID-19 impact;COVID-19 mortality;COVID-19 vaccine;Data;Data Set;Databases;Decision Making;design;disease model;dynamic system;Employee;Epidemiology;evidence base;flexibility;Future;General Population;Goals;Health;health data;Healthcare;human centered design;Individual;Intervention;Knowledge;Laws;Legal;Location;mathematical model;Medical;Methods;Minor;model building;Modeling;models and simulation;mortality;multidisciplinary;Outcome;outreach;Parental Consent;Parents;pediatrician;Pennsylvania;Pfizer-BioNTech COVID-19 vaccine;Policies;Politics;Population;population based;Population Dynamics;population health;predictive modeling;Provider;public database;Research;Research Personnel;Risk;SARS-CoV-2 transmission;Schools;simulation;sociodemographics;Surveillance Methods;System;Testing;therapy development;Thinness;transmission process;Update;Vaccinated;Vaccination;vaccine acceptance;vaccine access;vaccine hesitancy;Vaccines

PROJECT_TITLE: Modeling Adolescent Health Care Decision-Making for Vaccines: A Community- Based Participatory Approach

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Genetics;Human Genome;Rare Diseases

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Mitochondrial disease impacts 1 in 5000 adults and causes a range of negative effects on the nervous system, heart, eye, ear, kidney, blood and muscle and healthy aging. One reason we have few treatments and no cures has been the lack of animal models of these often devastating diseases. The purpose of this project is to make the first collection using custom programmed mitochondrial DNA variants of human clinical cases in the pioneering animal model, the zebrafish. Together, these in vivo avatars made using new mitochondrial gene editing technologies will enable new approaches for diagnoses and therapies for these terrible diseases.

PI_NAMEs: EKKER, STEPHEN CARL (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: 3-Dimensional;Address;Adenine;adenosine deaminase;Adult;Aging;Alleles;Animal Disease Models;Animal Model;Animals;Apoptosis;base;base editing;base editor;Basic Science;Biochemical;Biological;Biology;Blood;Cardiac;Cell model;Cells;Clinical;Code;Collection;Communities;community engagement;Custom;Cytosine;Diagnosis;Disease;Ear;Education;effective therapy;empowerment;Endocrine;Eye;Fertility;Fishes;gene complementation;gene editing technology;Gene Structure;Genes;Genetic;Genetic Diseases;genetic manipulation;Genetic Variation;Genome;genome editor;Genotype;Germ Lines;Health;healthy aging;Hearing;Heart;heteroplasmy;Homeostasis;Human;imaging science;in vivo;in vivo Model;International;Kidney;Knock-out;Liver;Maintenance;Measurement;Metabolic;metabolic phenotype;Metabolism;Methods;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;mitochondrial genome;Modeling;Molecular;monomer;muscle aging;muscular system;Nature;Nervous System;neural;Neurologic;novel strategies;Nuclear;Organ;Organelles;Outcome;outreach;Patients;Phenotype;phenotypic data;Prevalence;Printing;Proteins;Publications;Reagent;Research;Resources;RNA;Role;Science;Scientist;Series;Signal Transduction;Single Nucleotide Polymorphism;Skeletal Muscle;System;Technology;Testing;Tissues;tool;Transfer RNA;Validation;Variant;Vertebrates;Visual;Work;Zebrafish

PROJECT_TITLE: Modeling mtDNA Disease in vivo

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-Y (55)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Antimicrobial resistance (AMR) is one of the most critical public-health threats of the 21st century associated with an estimated 4.95 million deaths in 2019. Our postdoctoral training program will prepare the next generation of clinicians and scientists on the complex and multidisciplinary aspects of AMR. These trainees will be poised to become future leaders in the field and tackle the dire impact that AMR has on human health.

PI_NAMEs: ARIAS, CESAR AUGUSTO (contact)

PROGRAM_OFFICER_NAME: BROWN, LILIANA L

PROJECT_TERMS: Antimicrobial Resistance;Medical center;Texas;Training Programs

PROJECT_TITLE: Antimicrobial Resistance Training Program in the Texas Medical Center (AMR-TPT)

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Research Study Section[MID]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Chronic Pain;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pain Research

ORG_CITY: CORAL GABLES

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE Our program aims to provide neurosurgery residents with the opportunity to engage in significant structured research during their residency by coupling residents with established productive mentors. Our trainees will be supported throughout their research project from conception to publication, eventually facilitating their transition to junior faculty positions with dedicated NIH funding (K-or R equivalent). The University of MIami Neurosurgery eDucation Strategy (UMINDS) will foster the development of research scientists in our program and prepare them for careers as independent NIH funded researchers.

PI_NAMEs: DIETRICH, W DALTON;IAVARONE, ANTONIO ;LEVI, ALLAN D. (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Absence of pain sensation;Adaptor Signaling Protein;Address;Affect;Animal Model;Apoptosis;Biochemical Pathway;Biological Markers;biomedical referral center;Blood;Blood specimen;career;CASP1 gene;Caspase;Cell Death;cell injury;Cells;Cellular Stress;Central Nervous System;chronic pain patient;Climate;Clinical Research;Clinical Skills;clinically relevant;cohort;Collection;Combined Modality Therapy;Communities;Complex;Conceptions;Consumption;Coupling;cytokine;dalton;Dedications;Diabetes Mellitus;Disease;Disparity;Doctor of Philosophy;Education;Education Projects;education research;epidemiology study;Etiology;experience;Extracellular Matrix Degradation;Faculty;Fostering;Funding;Future;Genomics;Goals;Health;health disparity;Hypertension;IL18 gene;Immune;improved;In Vitro;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Innate Immune System;Institution;interest;Interleukin-1 beta;Interleukins;Intervention;Intervertebral disc structure;intervertebral disk degeneration;Investigation;K-Series Research Career Programs;Knowledge;Laboratories;Ligation;Liquid substance;Malignant Neoplasms;Measures;mechanical force;Mechanics;Mediating;Mediator;Medical;Mentors;Mentorship;milligram;Morphine;Multiple Sclerosis;Multiprotein Complexes;Narcotics;Nerve;Nerve Root Compressions;Nerve Tissue;Nervous System Trauma;Neurobiology;Neurodegenerative Disorders;Neurological disability;Neurons;Neurosciences;neurosurgery;novel;Occupational Therapy;Operative Surgical Procedures;Opioid;Outcome;Pain;Pain management;pain score;pathogen;Pathologic Processes;Pathway interactions;patient biomarkers;Patients;perineural;Peripheral;peripheral blood;Peripheral Nervous System;Positioning Attribute;Postoperative Pain;Postoperative Period;pre-clinical;Principal Investigator;Productivity;programs;Proteins;Publications;Qualifying;Quality of life;radicular pain;Radiculopathy;receptor;recruit;Reporting;Research;research and development;Research Personnel;Research Project Grants;Residencies;response;Role;Sampling;Schwann Cells;Scientist;Serum;Severities;Signaling Protein;Source;Spinal Degenerative Disorder;Spinal nerve root structure;Spinal nerve structure;Stains;Stroke;Structure;Surgeon;Symptoms;Therapeutic Monoclonal Antibodies;Tissue Survival;Tissues;Training Programs;Translating;Translational Research;United States National Institutes of Health;Universities;Up-Regulation;Work

PROJECT_TITLE: University of MIami Neurosurgery eDucation Strategy UMINDS

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-B (25)]


NIH_SPENDING_CATS: Hematology

PHR: Project Narrative Hematologic diseases affect millions of individuals throughout the United States. The goal of this program is to train the next generation of investigators in academic hematology who will develop new diagnostics and therapeutics for patients with these disorders.

PI_NAMEs: CHOI, SUNG WON ;SHAVIT, JORDAN A (contact)

PROJECT_TERMS: Hematology;Training Programs

PROJECT_TITLE: Boxer Training Program in Hematology


NIH_SPENDING_CATS: Bioengineering;Cardiovascular

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE An interdisciplinary approach is required to better prepare future surgeons and engineers for the challenges and opportunities in cardiovascular research. The CVISE T32 training program synergizes the training of post- doctoral surgeon-scientists and pre-doctoral graduate engineering students to focus on key modern topics spanning the field of cardiovascular disease diagnosis, treatment, and prevention. Graduates from this highly institutional supported program will acquire the skillsets necessary to transition into independent investigators who are capable of collaboratively investigating cardiovascular diseases, and developing innovations that will have a lasting impact on healthcare and society.

PI_NAMEs: GENIN, GUY M;LEUTHARDT, ERIC CLAUDE;ZAYED, MOHAMED A. (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Cardiovascular system;Engineering;innovation;Operative Surgical Procedures;programs

PROJECT_TITLE: Cardiovascular Innovation Program in Surgery & Engineering


PHR: Project Narrative Our program identifies, recruits, trains, and mentors a diverse workforce of compassionate and dedicated future physician-scientists. These Vanderbilt-trained physician-scientists serve critical needs in all aspects of medicine, science, industry, and government to improve human health, reduce disparities, and improve society through leadership in biomedical research and clinical practice. The public health benefit is realized through the integrated clinical and research accomplishments of our graduates as they elucidate the basic mechanisms of disease and capitalize on these discoveries in developing new therapeutic agents and strategies.

PI_NAMEs: WILLIAMS, CHRISTOPHER S. (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: Medical Scientist Training Program

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Pediatric

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Respiratory diseases account for approximately a quarter of all pediatric clinical consultations and hospital admissions in the United States, and pneumonia is the leading cause of death in children worldwide. There remains a critical shortage of trained investigators in pediatric respiratory diseases in the United States, despite clear evidence that the onset of lung disease in childhood is a strong predictor for respiratory disease in later life and prevention and/or treatment of childhood respiratory diseases has the potential to significantly reduce disease and medical costs associated with disease in later life. Our T32 training program in the Eudowood Division of Respiratory Sciences at Johns Hopkins University, now in its 20th year, has a strong track record of success in preparing young investigators who can discover novel mechanisms to improve diagnosis and treatment of pediatric respiratory diseases, attain career development funding, and transition into independent leaders within the field.

PI_NAMEs: COLLACO, JOSEPH MICHAEL (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TITLE: Multidisciplinary Training Program in Pediatric Pulmonary


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Radiation Oncology;Women's Health Research

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE. Triple-negative breast cancer (TNBC) is a highly aggressive sub-type of breast cancer that is characterized by poor survival, early spread of cancer cells to other organs, and a relative lack of therapies which specifically target cancer cells. This goal of this project is to develop a more effective strategy to treat TNBC by targeting specific receptors found on tumor cells, using targeted radionuclide treatments that destroy cancer cells, but are not harmful to normal tissue. To achieve this goal, we will develop a theranostic targeting peptide that will specifically deliver cytotoxic levels of radiation dose precisely to TNBC; this targeting peptide will be optimized, validated, and then tested for imaging and treatment in TNBC mouse models.

PI_NAMEs: BEINAT, CORINNE  (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: Affinity;Antibodies;Base Sequence;Benchmarking;Binding;Biodistribution;Biological;Biology;Breast Cancer Cell;Breast Cancer Patient;cancer cell;cancer diagnosis;Cancer Etiology;Cells;Cessation of life;Chelating Agents;chemotherapy;Clinical;clinical translation;clinically relevant;comparative;Complex;cost;Cyclization;cytotoxic;cytotoxic radiation;density;design;Development;Diagnosis;Diagnostic Imaging;Disease;disorder control;Dose;Drug Kinetics;ERBB2 gene;Estrogen Receptors;Exhibits;Extracellular Domain;FOLH1 gene;Foundations;Future;Gallium;glycosylation;Goals;Hematology;Image;imaging approach;immunogenicity;improved;in vivo;knock-down;Knowledge;Label;Libraries;Lutetium;Malignant Breast Neoplasm;Malignant Neoplasms;Masks;metal chelator;Metastatic breast cancer;Mind;Minisatellite Repeats;Minority Groups;Modeling;Modification;Molecular;molecular subtypes;molecular targeted therapies;Morbidity - disease rate;mortality;mouse model;Mucin 1 protein;Neoplasm Metastasis;neoplastic cell;Normal Cell;Normal tissue morphology;novel;optimal treatments;Organ;overexpression;Patients;Pattern;Peptides;Positron-Emission Tomography;Production;Progesterone Receptors;Prognosis;Property;protein aminoacid sequence;Proteins;Radiation Dose Unit;Radioisotopes;Radiolabeled;Radionuclide therapy;radiotracer;Randomized Controlled Clinical Trials;receptor;receptor binding;receptor density;receptor internalization;safety assessment;Serum;side effect;single photon emission computed tomography;Small Interfering RNA;Somatostatin Receptor;Specificity;subcutaneous;Surface Plasmon Resonance;Systemic Therapy;Tandem Repeat Sequences;targeted treatment;Techniques;Testing;theranostics;Therapeutic Studies;therapeutic target;Toxic effect;triple-negative invasive breast carcinoma;tumor;uptake;Validation;vector;Vertebral column;Woman

PROJECT_TITLE: Novel MUC1 Theranostic Peptides for Imaging and Treatment of Triple-Negative Breast Cancer

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Cerebrovascular;Digestive Diseases;Emerging Infectious Diseases;Hepatitis;Infectious Diseases;Liver Disease;Neurosciences

ORG_CITY: BLACKSBURG

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative Hepatitis E virus (HEV) is an important but extremely understudied human pathogen causing significant clinical problems worldwide including numerous extrahepatic manifestations. We will identify the underlying mechanisms of hepatitis E virus extrahepatic pathogenesis through infection of neuronal cells in vitro and in a rodent animal model during HEV infection. The information obtained from this project will inform potential therapeutic targets for HEV-associated neurological sequelae.

PI_NAMEs: MENG, XIANG-JIN  (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Acute;Acute Hepatitis;adverse outcome;Animal Model;Astrocytes;Brain;brain endothelial cell;brain tissue;CASP1 gene;Cell Death;cell type;Cells;Cessation of life;Chronic Hepatitis;Clinical;comparison control;cytokine;Development;Encephalitis;Extrahepatic;Family suidae;foodborne;Genotype;Gerbils;Goals;Guillain Barré Syndrome;Hepatic;Hepatitis;Hepatitis E;Hepatitis E virus;human pathogen;IL18 gene;Immune;Immunocompetent;In Vitro;in vivo;Individual;Infection;Inflammasome;Inflammatory;Interferon Type II;Interleukin-1 beta;interleukin-1beta-converting enzyme inhibitor;Invaded;Lesion;Literature;Mediating;Microglia;Modeling;mortality;nerve injury;Nervous System Trauma;Neuralgic Amyotrophy;neuroinflammation;Neurologic;Neurons;neurovascular unit;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;Pilot Projects;Predisposition;Pregnancy;Publications;Publishing;Reporting;Rodent;Role;Spinal Cord;therapeutic target;Tissues;TNF gene;VDAC1 gene;viral RNA;Virus Diseases;Zoonoses

PROJECT_TITLE: A gerbil model to delineate the mechanism of hepatitis E virus extrahepatic pathogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 VDT-Q (01)]


ORG_CITY: MINNEAPOLIS

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE As we age, we accumulate “senescent” cells which have a detrimental effect on various organs and tissues, including the immune system, which limits our ability to fight off infections. In this proposal, a team of experts on the biology of aging and immune responses to pathogens combine forces to determine which populations of senescent cells are responsible for these effects, the components of the immune system that they compromise – and how these detrimental effects can be reversed by elimination of senescent cells, using defined and novel therapeutics.

PI_NAMEs: JAMESON, STEPHEN C (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Ablation;Adaptive Immune System;Address;Adverse effects;Affect;Age;Age Distribution;age related;age related changes;aged;Alzheimer's Disease;Bioinformatics;Biology of Aging;Bystander Effect;Cell Aging;Cell Physiology;Cell surface;cell type;Cells;chemokine;clinical application;Clinical Trials;COVID-19 pandemic;COVID-19 patient;cytokine;cytokine release syndrome;Data;Defect;Degenerative polyarthritis;Elderly;exhaustion;experience;Exposure to;fighting;frailty;Functional disorder;Generations;Genetic Models;Genetically Engineered Mouse;Homeostasis;Housing;Human;Immune;immune activation;immune clearance;immune function;Immune response;Immune system;Immune System Diseases;immunodeficiency;Immunologic Memory;immunopathology;immunosenescence;Impairment;improved;Infection;Inflammatory;Innate Immune System;Interruption;Lymphoid;Mediating;microbial;microbial products;Modeling;Molecular;mortality;mouse model;Mus;National Institute of Allergy and Infectious Disease;Nature;novel;novel therapeutic intervention;novel therapeutics;old mice;Organ;Organism;Outcome;pathogen;pathogen exposure;Pathology;Peripheral;Pharmaceutical Preparations;Population;preclinical study;Process;Production;Reporting;Research;Resistance;Resistance to infection;response;Role;SARS-CoV-2 infection;senescence;senescence associated secretory phenotype;senescent cell;senolytics;single cell analysis;Standardization;Surface Antigens;Testing;Tissues;Translating;Virus;Virus Diseases;Work

PROJECT_TITLE: The role of senescent cells in dysregulating immune responses and pathogen control

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 LP-I (S2)]


NIH_SPENDING_CATS: Aging;Infectious Diseases

PROJECT_TERMS: Ablation;Acceleration;adaptive immune response;Adverse effects;Age;age effect;Aging;animal old age;Award;Biochemistry;Biology of Aging;Biophysics;career development;Cell Aging;cell type;Cells;Cessation of life;Chairperson;Chronic;Chronic Disease;Communication;Communities;Complex;Data;data resource;Elderly;Ensure;Excision;experience;Experimental Pathology;Exposure to;Faculty;Fostering;Funding;Genetic;Genetic Models;Goals;Grant;Human Resources;Immune;immune function;Immune response;Immunology;Impairment;Infection;Inflammatory;innovation;interdisciplinary approach;Laboratories;Lead;Leadership;Lymphoid;Medicine;member;Metabolism;Minnesota;Molecular Biology;Monitor;mouse model;Mus;National Institute of Allergy and Infectious Disease;Nature;novel therapeutic intervention;old mice;Organ;pathogen;pathogen exposure;Pathology;Pharmaceutical Preparations;pharmacologic;Physiological;Play;prevent;Production;Productivity;professor;programs;Publications;Publishing;Qualifying;Reagent;Regulation;Research;Research Activity;Research Personnel;Research Project Grants;Resources;Role;Science;Scientific Evaluation;senescence;senescent cell;Senior Scientist;senolytics;Series;sound;synergism;Technology;Testing;Tissue Sample;Tissues;tool;Transgenic Model;Transgenic Organisms;United States National Institutes of Health;Universities;Work


NIH_SPENDING_CATS: Aging;Genetics;Infectious Diseases

PI_NAMEs: HAMILTON HART, SARA ELIZABETH (contact)

PROJECT_TERMS: Ablation;Acute;adverse outcome;Affect;Age;age acceleration;aged;Aging;Animal Experiments;Anti-viral Response;antiviral drug development;AP20187;Autopsy;Beds;Breeding;C57BL/6 Mouse;CASP8 gene;CDKN2A gene;Cell Aging;cell type;Cells;Chronology;cohort;cost;cost effective;Databases;Dimerization;Disease;DNA Damage;DNA Repair Endonuclease;Drug or chemical Tissue Distribution;Ensure;Enterobacteria phage P1 Cre recombinase;ERCC1 gene;experience;experimental study;Exposure to;Flow Cytometry;Genetic;Genetically Engineered Mouse;Goals;Hematopoietic System;Immune;immune function;Immune response;Immune system;Immune System Diseases;immune system function;Immunologics;improved;In Vitro;Infection;innovation;Intravenous;Investigation;Laboratory mice;LoxP-flanked allele;Maintenance;Measurement;Mediating;Methods;Microbe;microbial;Modeling;mortality;mouse model;Mouse Strains;Murine hepatitis virus;Mus;National Institute of Allergy and Infectious Disease;novel;old mice;Ovalbumin;pathogen;pathogen exposure;Peptides;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Polyadenylation;Population;programs;promoter;Quality Control;Reporter;Reproducibility;Research Personnel;Resources;response;Role;senescence;senescent cell;senolytics;Signal Transduction;single-cell RNA sequencing;Specific qualifier value;Standardization;T-Cell Receptor;Tacrolimus Binding Proteins;Testing;Tissue Banks;Tissues;Titrations;tool;Transgenic Mice;Transgenic Organisms;Vendor;Vesicular stomatitis Indiana virus;Virus;Wild Type Mouse;Work

PROJECT_TITLE: Mouse and Infection Models


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Genetics;Human Genome;Infectious Diseases;Networking and Information Technology R&D (NITRD)

PI_NAMEs: DONG, XIAO  (contact)

PROJECT_TERMS: Affect;antibody conjugate;Bioinformatics;bioinformatics pipeline;Biology of Aging;Cell Aging;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Communities;computational pipelines;Computer Analysis;Computers;Computing Methodologies;computing resources;CRISPR screen;Custom;Cytometry;Data;Data Analyses;data exchange;data integration;Data Set;data sharing;Data Storage and Retrieval;Databases;design;Development;Dryness;Ensure;Experimental Designs;Formalin;Gene Expression;Genomics;Goals;Image;Immune;Immune response;Immunology;Individual;Infection;Information Technology;innovation;Laboratories;Lymphoid Cell;Metals;Methods;Minnesota;multiple datasets;Mus;Network Infrastructure;Oligonucleotides;Organ;Paraffin Embedding;pathogen;Phenotype;Population;Program Research Project Grants;programs;Protocols documentation;Reagent;Recommendation;Role;Sampling;senescent cell;Services;single cell analysis;single cell genomics;single-cell RNA sequencing;spatiotemporal;Standardization;Statistical Data Interpretation;Statistical Methods;Supercomputing;Suspensions;synergism;Technology;Time;Tissue Embedding;Tissues;transcriptome sequencing;transcriptomics;Universities;Vaccination;Validation;Visualization;web server

PROJECT_TITLE: Single Cell Analysis Core


NIH_SPENDING_CATS: Aging;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Genetics;Immunotherapy;Infectious Diseases

PI_NAMEs: NIEDERNHOFER, LAURA JANE (contact)

PROJECT_TERMS: 2019-nCoV;adaptive immune response;adaptive immunity;Address;Adipocytes;Adoptive Transfer;Adverse effects;adverse outcome;Age;age related;age-related disease;aged;Aging;aging population;aging related;Animals;AP20187;Astrocytes;Automobile Driving;betacoronavirus;Brain;CD8-Positive T-Lymphocytes;CDKN2A gene;Cell Physiology;Cell Separation;cell type;Cells;Cessation of life;chemokine;Chronic;Community-Acquired Infections;cost;COVID-19 pandemic;COVID-19 patient;cytokine;cytokine release syndrome;Data;DNA Repair Gene;Dose;Elderly;Enterobacteria phage P1 Cre recombinase;Equation;Excision;experience;Exposure to;Fatty acid glycerol esters;Foundations;Functional disorder;gain of function;genetic approach;Genotoxic Stress;Heart;Hematopoietic System;Hepatocyte;high risk;Human;Immune;immune function;Immune response;Immune system;Immune System Diseases;Immunologics;improved;In Vitro;in vivo;Individual;Infection;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;innovation;Kidney;Knowledge;Laboratory mice;Life;life span;Liver;logarithm;loss of function;Macrophage;Measures;Microbe;microbial;Modeling;Molecular;Morbidity - disease rate;mortality;Multiple Organ Failure;Murine hepatitis virus;Mus;Natural Killer Cells;Neurons;normal aging;novel;novel strategies;old mice;Older Population;Organ;Organism;pathogen;Pattern;Pharmaceutical Preparations;pharmacologic;Physiological Processes;Play;Predisposition;prevent;resilience;Role;senescence;senescence associated secretory phenotype;senescent cell;Senotherapeutic;sepsis induced ARDS;Serology;Serum;Specific qualifier value;Splenocyte;Sterility;Syndrome;T-Lymphocyte;Testing;Therapeutic;therapeutic target;Tissues;Transgenic Organisms;Translations;Virus;Virus Diseases;Wild Type Mouse;Work;wound healing

PROJECT_TITLE: Identification of senescent cell types


PROJECT_TERMS: 2019-nCoV;Ablation;Acute;adaptive immune response;Address;Affect;Age;age related changes;age related decline;aged;Aging;animal old age;Animals;Architecture;Attenuated;attenuation;Automobile Driving;B-Lymphocytes;Biological Assay;Bystander Effect;CD8-Positive T-Lymphocytes;Cell Aging;Cell Cycle;cell type;Cells;Characteristics;chemokine;Chronic Disease;COVID-19 patient;CRISPR screen;CRISPR/Cas technology;cytokine;cytokine release syndrome;Data;Defect;Diabetes Mellitus;Elderly;Environment;Exposure to;Feedback;Functional disorder;Generations;Goals;Homeostasis;Human;Immune;immune clearance;immune function;Immune mediated destruction;Immune response;Immune system;Immune System Diseases;Immunity;Immunologic Memory;Immunomodulators;immunopathology;immunoregulation;Impairment;improved;In Vitro;Individual;Infection;Inflammatory;Innate Immune Response;insight;Knowledge;Ligands;Link;Literature;Lymphocyte;Lymphoid;Lymphoid Tissue;Maintenance;Mediating;Memory;Metabolic Diseases;microbial;microbial products;model development;Modeling;Molecular;mouse model;Mus;Natural Killer Cells;novel;novel strategies;Obesity;old mice;pathogen;Pathway interactions;Physiological;Physiology;Play;Population;Production;Publishing;receptor;Regulation;Reporting;resilience;Resistance;Resistance to infection;response;Risk;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;senomorphic;Senotherapeutic;single cell analysis;Source;Sterility;Stress;synergism;T memory cell;T-Lymphocyte;Testing;Tissues;Vaccination;vaccine efficacy;Virus Diseases;Vulnerable Populations;Work

PROJECT_TITLE: Effect of senescent cells


PI_NAMEs: MASOPUST, DAVID  (contact)

PROJECT_TERMS: Ablation;Adult;Affect;Age;age effect;aged;Aging;Antigens;Bioinformatics;Biology;Breast;CD8B1 gene;Cell Culture Techniques;cell type;Cells;Cellular Assay;Cellular Stress;Chronic Disease;Cues;cytokine release syndrome;Elderly;Environment;Event;Gene Expression Alteration;Goals;Hematopoietic;Homeostasis;Human;human tissue;Immune;Immune response;Immune System Diseases;Immunity;Immunologic Memory;Immunologic Surveillance;improved;In Vitro;Individual;Infection;Inflammation;Leukocytes;Longevity;lymph nodes;Maintenance;Malignant Neoplasms;Methods;microbial;Modeling;Mus;old mice;Organism;pathogen;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Population;programs;Rejuvenation;Resources;response;Risk;Role;Sampling;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Senotherapeutic;Senotherapy;Series;Shapes;Signal Transduction;Site;Skin;Stomach;Stress;Study models;T cell differentiation;T-Lymphocyte;Test Result;Testing;Therapeutic;tissue resident memory T cell;Tissues;tumor;Vaccination;Work

PROJECT_TITLE: Effect of aging and senescent cells


NIH_SPENDING_CATS: Cancer;Prevention

ORG_CITY: BOSTON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: Project Narrative This training program is in its 29ᵗʰ year, and has trained 126 fellows in transdisciplinary approaches to cancer prevention and control. Over 80% of trainees are in research positions, and approximately 30% of trainees have come from underrepresented minority (URM) backgrounds (38% in current cycle). The maturity of this Program, extensive resources available through Harvard and synergy across the focal training areas provide an outstanding platform for training the next generation of cancer prevention scientists.

PI_NAMEs: EMMONS, KAREN M. (contact);FRAZIER, ANNE LINDSAY

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TITLE: The Harvard Chan Education Program in Cancer Prevention and Control

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Lung

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Physician scientists play an important role in addressing the prevention and management of heart, lung, blood, and sleep disorders through research whose findings can advance the development of new diagnostic, treatment, and prevention strategies. The goal of this renewal proposal is to continue to provide medical students with skills and knowledge in translational research through mentored research experiences at the University of Alabama at Birmingham that are concentrated in heart, lung, and/or blood fields and through didactics. The impact of the program will be the development of a diverse group of highly motivated, well-trained, early physician scientists who are interested in and motivated for pursuing an academic medicine career involving heart, lung, and/or blood research.

PI_NAMEs: GEISLER, WILLIAM M (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Address;Advanced Development;Alabama;Blood;career;career development;Clinical;Curiosities;Data;Development;diagnostic strategy;Disease;Ethnic Origin;experience;Female;Funding;gender diverse;global health;Goals;Health Professional;Heart;Heart Diseases;Hematological Disease;interest;Knowledge;Lung;Lung Diseases;medical schools;Medical Students;Medicine;Mentors;Mentorship;Motivation;National Heart, Lung, and Blood Institute;next generation;novel diagnostics;Outcome;Participant;Pathway interactions;Pear;peer;Physicians;Prevention strategy;programs;Publications;Race;recruit;Reproducibility;Research;research and development;Research Training;Resources;responsible research conduct;Role;Schools;Scientist;skills;Sleep Disorders;Students;Training;Translational Research;treatment strategy;Universities;Vocational Guidance

PROJECT_TITLE: UAB Short-Term Research Training in Health Professional Schools (SHRT)

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-B (O1)]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: RUTGERS CANCER INSTITUTE OF NEW JERSEY PUBLIC HEALTH RELEVANCE STATEMENT The catchment area of Rutgers Cancer Institute of New Jersey (CINJ) is the state of New Jersey (NJ), with a diverse population of over 9.2 million. In 2019, NJ ranked 6th in cancer incidence rates nationwide with 483.7 cases per 100,000 (54,271 cases). CINJ is the State of New Jersey's only National Cancer Institute (NCI)- designated Comprehensive Cancer Center. The mission of CINJ is to reduce the burden of cancer by advancing cancer research, prevention, screening and education for the most densely-populated and one of the most ethnically and socioeconomically diverse states in the US.

PI_NAMEs: LIBUTTI, STEVEN K. (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Acceleration;Address;Advanced Malignant Neoplasm;Advocacy;Agreement;anti-cancer research;Appointment;Award;Basic Science;biobank;biomedical informatics;Biometry;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Cancer Control;cancer genetics;Cancer health equity;Cancer Hospital;Cancer Institute of New Jersey;Cancer Patient;cancer pharmacology;cancer prevention;cancer risk;Cancer Survivor;cancer therapy;career;Catchment Area;Clinical;clinical investigation;Clinical Research;Clinical Trials;Collaborations;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;County;Data;Education;Equity;equity, diversity, and inclusion;Ethnic Origin;Evaluation;evidence base;Evidence based intervention;Evolution;Faculty;Faculty Recruitment;Family member;Flow Cytometry;Funding;Future;Future Teacher;genome editing;Genomic Instability;Genomics;graduate student;Grant;Growth;health care quality;Health Sciences;Health system;Histopathology;Home;Hospitals;Human;Immunologic Monitoring;improved;Incidence;Individual;innovation;Institution;interdisciplinary collaboration;Intervention;investigator-initiated trial;Investments;Joints;Leadership;leadership development;Malignant Childhood Neoplasm;Malignant Neoplasms;member;metabolomics;Minority Groups;Mission;Modeling;multidisciplinary;National Cancer Institute;New Jersey;novel;Nurses;oncology service;Outcome;outreach;Pathogenesis;Patient Care;patient screening;Patients;Peer Review;Physicians;Policies;Population;Population Heterogeneity;Postdoctoral Fellow;Precision therapeutics;Prevention;Program Development;programs;public health relevance;Public Policy;Quality of life;Research;Research Activity;Research Infrastructure;Research Institute;Research Personnel;Resource Sharing;Resources;Risk;Role;Science;screening;Screening for cancer;Services;Site;socioeconomics;Strategic Planning;Structure;success;System;Therapeutic Intervention;Therapeutic Trials;Training;Training and Education;Translating;tumor immunology;tumor metabolism;undergraduate student;Underrepresented Minority;Underrepresented Populations;Universities;Vision;Visit;Work

PROJECT_TITLE: Cancer Center Support Grant

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer;Immunotherapy

PHR: PROJECT NARRATIVE Not required per PAR-21-321 (Cancer Center Support Grants (CCSGs) for NCI-designated Cancer Centers (P30 Clinical Trial Optional)

PI_NAMEs: TANZER, LINDA LOUGHMAN (contact)

PROJECT_TERMS: Accounting;Achievement;Address;Agreement;Applications Grants;Area;Award;biomedical informatics;Budgets;Businesses;Cancer Center;Cancer Center Support Grant;Cancer health equity;cancer immunotherapy;Cancer Institute of New Jersey;career development;Catchment Area;Clinical Data;Clinical Protocols;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;COVID-19;Data;Data Analytics;Development;Education;Effectiveness;Ensure;equity, diversity, and inclusion;Evaluation;Event;Evolution;expectation;Expenditure;experience;Faculty;Faculty Recruitment;faculty support;Floor;Funding;Goals;Grant;Growth;Guidelines;Health;Health system;Human Resources;impression;improved;Instagram;Institution;International Aspects;Intervention;Journals;Laboratories;Leadership;Malignant Neoplasms;Measures;meetings;Mentorship;Mission;Modeling;Monitor;NCI-Designated Cancer Center;Network Infrastructure;news;Newsletter;novel;Occupations;Operations Research;Patients;Peer Review;Pilot Projects;Play;Policies;Population Sciences;post-COVID-19;Prevention;Process;process improvement;programs;Public Policy;Publications;Quality Control;recruit;Reporting;Research;Research Personnel;Resource Sharing;Resources;response;Role;satisfaction;Schools;Science;Series;service utilization;social media;Strategic Planning;Technology;Thinness;Training and Education;treatment trial;tumor immunology;Twitter;Universities;Update;vigilance;Work;Workforce Development

PROJECT_TITLE: Cancer Center Administration


NIH_SPENDING_CATS: Cancer;Pediatric

PI_NAMEs: LATTIME, EDMUND C. (contact)

PROJECT_TERMS: Address;Advisory Committees;anti-cancer research;Award;Cancer Biology;cancer care;Cancer Center Support Grant;cancer education;cancer genomics;Cancer health equity;Cancer Institute of New Jersey;career;Catchment Area;Clinical;Clinical Trials;college;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;County;curriculum development;Development;Disparity;Diverse Workforce;Doctor of Philosophy;Education;education research;Educational Status;English Language;Environment;equity, diversity, and inclusion;Evolution;Faculty;Family;Funding;Future;Geography;Goals;Grant;high school;Home;Immigrant;Incentives;Income;Individual;Institution;K-12 student;Kansas;Malignant Neoplasms;Medical;Medical center;meetings;member;Mentors;Mentorship;Minority Groups;multidisciplinary;NCI-Designated Cancer Center;New Jersey;next generation;Outcome;Patients;Population;Population Density;post-doctoral training;Postdoctoral Fellow;professor;programs;Reporting;Research;Research Personnel;Resources;Science;science teacher;Scientist;Secure;Specialist;Strategic Planning;Students;summer internship;Systems Biology;Training;Training and Education;Training Programs;Travel;undergraduate student;United States National Institutes of Health;Universities;Youth

PROJECT_TITLE: Cancer Research Training and Education Coordination


NIH_SPENDING_CATS: Cancer

PI_NAMEs: IN, HAEJIN  (contact)

PROJECT_TERMS: Acceleration;Address;Affect;anti-cancer research;Area;Automobile Driving;Awareness;built environment;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Institute of New Jersey;Catchment Area;Clinical Trials;Collaborations;Color blindness;community engagement;Community Outreach;demographics;Ensure;Environment;Equity;equity, diversity, and inclusion;Ethnic Origin;Evaluation;evidence base;Evidence based practice;experience;Faculty;Faculty Recruitment;Focus Groups;Fostering;Gender;Goals;graduate student;Healthcare;Home;improved;Inequity;Institution;Lead;Leadership;Measures;member;Mind;Mission;NCI-Designated Cancer Center;Needs Assessment;Oncology;Outcome;Participant;Patient Care;Patients;Persons;Policies;Population Heterogeneity;Positioning Attribute;Postdoctoral Fellow;Process;Program Evaluation;programs;Race;racial diversity;racism;Recommendation;recruit;Reporting;response;satisfaction;Science;Sexism;social;Strategic Planning;Structure;success;Surveys;Training and Education;undergraduate student;Underrepresented Populations;Woman;women faculty;Work

PROJECT_TITLE: Plan to Enhance Diversity


PI_NAMEs: ZHENG, STEVEN  (contact)

PROJECT_TERMS: Achievement;Address;Antineoplastic Agents;Back;base editing;Basic Science;Bioinformatics;Biological Response Modifier Therapy;Biology;biopharmaceutical industry;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Institute of New Jersey;cancer pharmacology;cancer therapy;Cardiovascular system;care outcomes;career;Catchment Area;cell growth;Cells;Cellular Metabolic Process;checkpoint therapy;Chemicals;Chemistry;chemobrain;chemotherapeutic agent;chemotherapy;chromatin remodeling;Clinic;clinical investigation;Clinical Trials;collaboratory;Communication;Communities;community engagement;Community Outreach;Development;Drug Delivery Systems;drug discovery;early-career faculty;Education;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Epigenetic Process;equity, diversity, and inclusion;Faculty;Faculty Recruitment;Fostering;Funding;Generations;Goals;Grant;Growth;improved;innovation;insight;Institution;interdisciplinary approach;International;Journals;Leadership;Licensing;Malignant Neoplasms;mathematical model;Medicine;member;Mentors;Mentorship;Metabolic;Molecular;Molecular Target;nanotherapeutic;Nature;NCI-Designated Cancer Center;New England;New Jersey;novel;novel therapeutics;Oncogenic;Outcome;painful neuropathy;Paper;Pathway interactions;Patient-Focused Outcomes;Peer Review;Pharmacology;Postdoctoral Fellow;pre-clinical research;Principal Investigator;professor;programs;Proliferating;protein data bank;Publishing;recruit;Regulation;Research;research and development;resistance mechanism;Resource Sharing;Resources;response;Schools;Science;Scientist;Signal Transduction;small molecule;Strategic Planning;targeted cancer therapy;Technology;technology development;Testing;Toxic effect;translational pipeline;Translational Research;Translations;Treatment outcome;undergraduate student;Universities;Work

PROJECT_TITLE: Cancer Pharmacology


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy

PI_NAMEs: ZONG, WEI-XING  (contact)

PROJECT_TERMS: Address;Anabolism;anti-cancer research;anti-tumor immune response;Area;authority;Award;base;Cancer Cachexia;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Institute of New Jersey;cancer therapy;Catchment Area;cell growth;Cell Therapy;Cells;Cellular Metabolic Process;Circulation;Clinical Research;Clinical Trials;Collaborations;community engaged research;community engagement;Community Outreach;Discipline;driver mutation;Foundations;Funding;gene therapy;Genetic;Goals;Grant;Growth;Health system;host neoplasm interaction;Immune;Immune Evasion;Immunologics;Immunology;immunoregulation;improved;innovation;Institution;Invaded;Journals;Malignant Neoplasms;member;Metabolic;metabolic abnormality assessment;Metabolic Control;metabolic fitness;Metabolic Pathway;Metabolism;NCI-Designated Cancer Center;Neoplasm Metastasis;neoplastic cell;novel;novel strategies;Nutrient;Nutritional Requirements;Oncogenic;Oxidation-Reduction;Paper;Peer Review;pharmacologic;Positioning Attribute;post-doctoral training;Process;Production;Prognosis;programs;Proliferating;Publishing;recruit;Regulation;Research;Research Institute;response;Risk Factors;Role;Signal Transduction;Site Visit;Sorbus;Stress;Therapeutic;Translational Research;treatment strategy;tumor;tumor growth;tumor immunology;tumor metabolism;Tumor-infiltrating immune cells;United States National Institutes of Health;Universities

PROJECT_TITLE: Cancer Metabolism and Immunology


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PI_NAMEs: BANDERA, ELISA V (contact)

PROJECT_TERMS: Address;anti-cancer research;Area;Asian population;Behavior;Behavioral Mechanisms;Behavioral Sciences;Biological Factors;Biological Markers;Black race;built environment;Cancer Burden;cancer care;Cancer Center Support Grant;Cancer Control;Cancer Control Research;cancer epidemiology;Cancer Etiology;cancer health disparity;Cancer health equity;Cancer Institute of New Jersey;cancer prevention;cancer risk;care coordination;care delivery;Caring;Catchment Area;Characteristics;Cigar;Cigarette;Clinical;clinical research site;Clinical Trials;cohort;Collaborations;Communication;Communities;community engagement;community organizations;Community Outreach;Development;digital;digital intervention;Direct Costs;Disparity;effective intervention;Electronic cigarette;Epidemiology;epidemiology study;ethnic disparity;Evaluation;experience;Extramural Activities;Faculty;falls;Family;Federally Qualified Health Center;Funding;General Population;Genetic;Genomics;Goals;Grant;Growth;Guidelines;Health;health equity;Health Policy;Hispanic;Human Papillomavirus;implementation evaluation;implementation intervention;implementation science;implementation strategy;improved;improved outcome;Incidence;Individual;Inequity;innovation;Institution;Integrated Health Care Systems;interdisciplinary collaboration;Intervention;Knowledge;Leadership;life span;Life Style;lifestyle factors;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Marketing;member;Mentors;Minority Groups;Modality;Molecular;Morbidity - disease rate;mortality;NCI-Designated Cancer Center;Neighborhoods;neoplasm registry;New Jersey;next generation;non-cigarette tobacco product;novel;Outcome;Paper;Patient Outcomes Assessments;Patients;Peer Review;Policies;Population;Population Research;Prevention;primary care practice;Primary Prevention;Productivity;professor;programs;Public Health;Public Health Practice;Publications;Publishing;Quality of life;racial disparity;Regulation;Reporting;Research;Research Design;Research Personnel;Research Training;Resource Sharing;Resources;Risk;Risk Factors;Risk Reduction;Role;Schools;Scientific Advances and Accomplishments;Scientist;screening;Self Efficacy;Skin tanning;social health determinants;social media;Social support;South Asian;Strategic Planning;survival outcome;Survivors;survivorship;System;technology intervention;Testing;therapy development;Tobacco;tobacco control;tobacco prevention;Tobacco use;Tobacco Use Cessation;Translating;translational impact;Translational Research;Translations;trend;tumor;Underrepresented Populations;Underserved Population;United States Dept. of Health and Human Services;United States Food and Drug Administration;Universities;Vulnerable Populations;Work

PROJECT_TITLE: Cancer Prevention and Control


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine;Prevention

PI_NAMEs: CHAN, CHANG S (contact)

PROJECT_TERMS: Area;Award;Basic Science;Biogenesis;BRCA1 gene;BRCA2 gene;Cancer Center;Cancer Center Support Grant;cancer genetics;cancer genome;Cancer Intervention;cancer risk;cancer type;Catchment Area;Cell Cycle;Cell Cycle Checkpoint;Cell Cycle Regulation;Cells;Chromosome Segregation;Classification;clinical investigation;clinical translation;Clinical Trials;Collaborations;Community Outreach;CRISPR screen;Development;DNA biosynthesis;DNA Damage;DNA Repair;DNA Repair Gene;DNA Sequence Alteration;Epigenetic Process;Exposure to;Faculty Recruitment;Fibroblast Growth Factor Receptor 2;Funding;Gene Expression;Gene Expression Profile;gene network;Genes;Genetic;Genetic Research;genetic resource;Genome;Genome Stability;Genomic approach;Genomic Instability;genomic tools;Genomics;Goals;Grant;Grant Review;Homeostasis;improved;inhibitor;innovation;Institution;interdisciplinary approach;Investigation;Joints;Journals;Knowledge;Leadership;Maintenance;Malignant Neoplasms;Medicine;member;Microtubules;mid-career faculty;Mitotic spindle;mutant;NCI-Designated Cancer Center;Neuroendocrine Tumors;novel;PALB2 gene;Pathway interactions;Peer Review;Pilot Projects;pre-clinical research;precision oncology;Precision therapeutics;Predisposition;prevent;Productivity;professor;Program Research Project Grants;programs;Publications;Qualifying;Radiation Oncology;recruit;replication stress;Research;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Ribosomes;Risk Factors;Role;Schools;Science;Scientist;Secure;single cell analysis;Strategic Planning;Subgroup;Systems Biology;targeted treatment;Technology;Therapeutic;Tissues;TOP1 gene;TP53 gene;Training;Translational Research;Translations;tumor;tumor growth;tumor progression;Tumor Suppression;tumorigenesis;Underrepresented Populations;United States National Institutes of Health;Universities;Validation;working group

PROJECT_TITLE: Genomic Instability and Cancer Genetics


NIH_SPENDING_CATS: Breast Cancer;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Lung;Lung Cancer;Precision Medicine;Prevention;Women's Health Research

PI_NAMEs: GANESAN, SHRIDAR  (contact)

PROJECT_TERMS: Achievement;Awareness;Back;Basic Science;bench-to-bedside translation;Biological Markers;Biological Models;biomarker identification;Black race;Breast Cancer Patient;Burkitt Lymphoma;cancer biomarkers;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genetics;cancer health disparity;cancer immunotherapy;cancer pharmacology;cancer prevention;cancer surgery;cancer therapy;Catchment Area;Cell Cycle Checkpoint;Cell Death;Cell Survival;checkpoint therapy;Classification;Clinic;Clinical;clinical development;clinical investigation;clinical prognostic;Clinical Research;clinical translation;Clinical Trials;clinically actionable;Collaborations;Communities;community engagement;Community Outreach;Dedications;Defect;Development;DNA Repair;early phase clinical trial;early phase trial;Ethnic Origin;FGFR2 gene;first-in-human;Funding;Genomic Instability;Genomics;Glucose;Goals;Grant;Human;Image Analysis;imaging approach;immune checkpoint;Immune Targeting;Immuno-Chemotherapy;improved;Individual;inhibitor;Investigation;Isotopes;Journals;Leadership;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Medical Oncology;meetings;member;Metabolic;Methodology;Modeling;Molecular;multidisciplinary;Mutation;NCI-Designated Cancer Center;Neoadjuvant Therapy;Neuroendocrine Tumors;New Jersey;Non-Small-Cell Lung Carcinoma;novel diagnostics;novel strategies;novel therapeutic intervention;Oncogenes;Outcome;Paper;Pathway interactions;Patients;Peer Review;Phage Display;Population;Population Sciences;Pre-Clinical Model;precision oncology;Precision therapeutics;Prevention;Productivity;prognostic index;programs;Proteins;Publications;Publishing;Radiation Oncology;rational design;recruit;Regimen;Research;Research Personnel;Resistance;response;response biomarker;Sampling;Schools;Science;Screening for cancer;Site Visit;Solid Neoplasm;Specimen;Surgical Oncology;Systems Biology;targeted treatment;Therapeutic;Therapeutic Research;Translating;Translations;triple-negative invasive breast carcinoma;tumor;tumor immunology;tumor metabolism;tumor-immune system interactions;United States National Institutes of Health;Universities;Validation

PROJECT_TITLE: Clinical Investigation and Precision Therapy


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention

PI_NAMEs: KINNEY, ANITA Y. (contact)

PROJECT_TERMS: Academy;Address;Advisory Committees;Advocacy;Affect;Area;Arts;Award;Breast;Cancer Burden;Cancer Center Support Grant;Cancer Control;cancer health disparity;Cancer health equity;Cancer Institute of New Jersey;cancer site;Caring;Catchment Area;Clinical Trials;Colorectal;Communities;community engagement;community organizations;Community Outreach;community partners;community partnership;community science;County;dashboard;Data;Data Collection;data dashboard;Decision Making;Detection;Development;digital;digital media;Disparity;diversity and inclusion;Education;Education and Outreach;Ensure;Equity;ethnic diversity;Evaluation;evidence base;Evidence based intervention;Faculty;Fostering;Foundations;Funding;Geographic Locations;Goals;Grant;Health;health care quality;Health Services Accessibility;Home;Human Papillomavirus;improved;Incidence;Language;Lesion;Logic;Lung;Malignant - descriptor;Malignant Neoplasms;meetings;Melanoma;member;Minority;Mission;model design;Monitor;mortality;NCI-Designated Cancer Center;New Jersey;organizational structure;Outcome;outreach;Policies;Population;Population Heterogeneity;Population Sciences;premalignant;Prevention;Preventive service;Printing;Professional Education;Program Development;programs;Prostate;Public Policy;Publications;Race;racial diversity;Reporting;Research;Research Personnel;Research Support;Risk Factors;Science;Scientist;Screening for cancer;Screening Result;Site;socioeconomics;Stage at Diagnosis;Strategic Planning;Subgroup;Touch sensation;Training;Training and Education;Visit;Voice;Work

PROJECT_TITLE: Community Outreach and Engagement


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PROJECT_TERMS: Acceleration;Address;anti-cancer research;Area;Award;Basic Science;Budgets;Cancer Center Support Grant;cancer health disparity;Cancer health equity;Cancer Institute of New Jersey;Cancer Survivorship;Catchment Area;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;commercialization;Communication;Communities;Community Outreach;Comprehensive Cancer Center;Data;data warehouse;Development;Developmental Process;Extramural Activities;Faculty;Faculty Recruitment;Focus Groups;Fostering;Foundations;Funding;Funding Mechanisms;Generations;Goals;Grant;health equity;Hematological Disease;Immunology;Informatics;innovation;Institution;interest;investigator-initiated trial;Investments;Laboratories;Leadership;Link;Malignant Childhood Neoplasm;Malignant Neoplasms;meetings;member;Metabolism;Mission;Monitor;NCI-Designated Cancer Center;New Jersey;Outcome;Peer Review;Philanthropic Fund;Pilot Projects;Policies;Population Research;Population Sciences;precision medicine;Process;programs;Publications;Recording of previous events;recruit;Reporting;Research;research faculty;Research Personnel;Research Project Grants;Research Support;Resources;Risk Factors;Science;Secure;Source;Strategic Planning;support tools;System;Training;Training Activity;Translational Research;Universities;Work

PROJECT_TITLE: Developmental Funds