ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE: Overall Section The Mutant Mouse Resource and Research Center (MMRRC) at UC Davis (MMRRC-UCD) is the flagship of the MMRRC Consortim, and serves a leading role in facilitating research by identifying, acquiring, evaluating, characterizing, cryopreserving, and distributing mutant mouse strains to qualified biomedical investigators. The MMRRC-UCD ensures that scientifically valuable transgenic, knockout, and other genetically-engineered mutant mice and related biomaterials of human disease, development, and behavioral abnormalities are maintained for investigational use across the biomedical scientific community. The MMRRC-UCD provides expertise, infrastructure, resources and services to preserve mouse strains in perpetuity, protect them from catastrophic loss, avoid genetic and phenotypic drift, prevent pathogenic contamination and disease, and conduct resource-related research to advance the study of mutant mice as models of human disease, including cancer. The MMRRC-UCD fosters and promotes the discovery of new diagnostics, treatments, and prevention strategies against human diseases, including cancer, optimizes reproducibility of studies, and assures scientific rigor and transparency.

PI_NAMEs: LLOYD, KC KENT (contact)

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Acceleration;Accountability;Advisory Committees;Agreement;Animal Model;Archives;Area;Behavioral;Biocompatible Materials;Biomedical Research;Breeding;Caring;Collaborations;Communities;CRISPR/Cas technology;Crossbreeding;Cryopreservation;Data;data sharing;Deposition;Derivation procedure;Development;diagnostic strategy;Disease;disease model;Embryo;embryonic stem cell;Ensure;ES Cell Line;Fee-for-Service Plans;Feedback;Fostering;Funding;Gene Targeting;Genetic;Genetic Engineering;Genetic Variation;genome editing;Genotype;Germ;Germ Cells;Goals;Guidelines;gut microbiome;Health;Health Services Accessibility;high risk;high standard;Human;human disease;Human Genetics;human model;improved;Informatics;Infrastructure;Knock-out;Maintenance;Malignant Neoplasms;Marketing;meetings;member;Metabolic;Methods;microbiota;Mission;Missouri;Modeling;mouse genetics;mouse model;Mouse Strains;Mus;Mutant Strains Mice;Names;Nerve Degeneration;new technology;North Carolina;novel diagnostics;pathogen;Pathogenicity;Phenotype;Play;Policies;preservation;prevent;Prevention strategy;Procedures;Process;programs;Protocols documentation;Qualifying;Quality Control;Recommendation;Recovery;Registries;repository;Reproducibility;Research;Research Personnel;research study;Resource Sharing;Resources;Role;Scientist;Services;Social Responsibility;Surveys;System;Technology;Testing;The Jackson Laboratory;Tissues;Transgenic Organisms;treatment strategy;United States;United States National Institutes of Health;Universities;Validation;Work

PROJECT_TITLE: Mutant Mouse Resource and Research Center at UC Davis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-C(50)]


ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Biotechnology;Genetics;Microbiome

ORG_CITY: DAVIS

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_STATE: CA

PROJECT_TERMS: Acceleration;Adopted;Advertising;Alleles;Analgesics;Applied Research;Archives;Area;Awareness;Bacterial Artificial Chromosomes;biobank;Biomedical Research;biomedical resource;Biotechnology;blastocyst;Breeding;California;Caring;Collection;Communities;congenic;Contracts;Cost efficiency;Country;CRISPR/Cas technology;Cryopreservation;Custom;Database Management Systems;Development;Disease;Diverse Workforce;Effectiveness;Embryo;embryonic stem cell;Ensure;Environment;Equipment;ES Cell Line;Ethylnitrosourea;Evaluation;Feedback;Freedom;Funding;Gene Targeting;genetic variant;genome editing;Genomics;Genotype;Goals;Guidelines;gut microbiome;Health;high standard;Human Resources;improved;Individual;Informatics;Information Dissemination;Infrastructure;Injections;innovation;Institution;Intracytoplasmic Sperm Injections;Knock-out;Leadership;Marketing;meetings;Mentors;microbiome analysis;microbiota transplantation;Mission;Modeling;Molecular Analysis;mouse model;multiple omics;Mus;mutant;mutant mouse model;Mutant Strains Mice;National Heart, Lung, and Blood Institute;next generation;online resource;operation;Outcome;pathogen;Performance;Phenotype;Policies;Positioning Attribute;Prevention;Procedures;programs;Protocols documentation;Published Comment;Recommendation;repository;Reproducibility;Research;Research Activity;Research Personnel;Research Project Grants;Resource Development;Resources;Role;Scientist;Security;Services;Speed;Technology;tool;Training;Transgenic Organisms;United States National Institutes of Health;Universities;web site;Work;zygote

PROJECT_TITLE: The Resource of the MMRRC at UC Davis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-C]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Digestive Diseases;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Soil-transmitted nematodes (intestinal parasitic nematodes) are one of the most prevalent human parasites on earth, causing significant morbidity, especially in children; they are major drivers of impoverishment in developing countries. This application uses a novel, newly developed drug discovery pipeline and high- throughput screen (HTS) platform to screen two drug libraries for highly active compounds that target divergent intestinal nematode parasites. At the end of the proposed research, we expect to have discovered new compound(s) that have good-excellent therapeutic activity against the parasites in infected animals.

PI_NAMEs: AROIAN, RAFFI V (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Adult;analog;Ancylostoma (genus);Ancylostoma caninum;Anemia;Animals;Anthelmintics;Antiparasitic Agents;Ascaris;Ascaris lumbricoides;Automation;benzimidazole;benzimidazole resistance;Biological Assay;Caenorhabditis elegans;Cell Line;Chemicals;cheminformatics;Child;Clinic;Clinical Research;Colon Carcinoma;Communities;data mining;Developing Countries;Development;Diagnosis;Disease;Dose;drug candidate;drug discovery;Drug Kinetics;Economics;Education;egg;enteric infection;Evaluation;Exclusion;Failure;Follow-Up Studies;Future;Growth;Hamsters;Health;Helminths;high throughput screening;Hookworms;Human;Impaired cognition;Impairment;in silico;In Vitro;in vitro testing;in vivo;in vivo evaluation;indexing;Individual;infected vector rodent;Informatics;Intestines;Intoxication;Larva;Lead;Libraries;Malignant Epithelial Cell;Malnutrition;Mammalian Cell;Maternal complication;Methods;molecular modeling;Morbidity - disease rate;Mothers;Multi-Drug Resistance;Mus;Necator;Nematoda;Nematode infections;novel;Parasite resistance;Parasites;Parasitic infection;Parasitic nematode;parasitism;Persons;Pharmaceutical Preparations;Phylogenetic Analysis;Planet Earth;Poverty;pre-clinical;Preclinical Drug Development;preclinical study;Pregnancy Complications;Pregnant Women;Primary carcinoma of the liver cells;Process;Production;Productivity;productivity loss;Recipe;Research;Resistance;resistance allele;response;Rodent;scaffold;screening;Soil;Sorting;Structure-Activity Relationship;System;Testing;Therapeutic;Toxic effect;transmission process;Trichocephalus trichiura;Trichuris;Validation

PROJECT_TITLE: Automated high throughput compound screening for broadly active anti-parasitic nematode drugs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-F(55)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: ATLANTA

ORG_DEPT: PATHOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE There is an unmet need in the HIV vaccine field for immunogens that consistently elicit potent and broad neutralizing antibodies. We have demonstrated that HIV-1 fusion peptide prime and Env boost is a promising strategy and will test novel immunogens and immunization strategies to improve the breadth, magnitude, and quality of the fusion peptide-directed neutralizing responses.

PI_NAMEs: KONG, RUI  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJALI

PROJECT_TERMS: Address;Amino Acids;Animals;Antibodies;Antibody Response;Antigens;B-Lymphocytes;Binding;Carrier Proteins;Cavia;Cells;Chikungunya virus;Circulation;cross reactivity;Data;design;Epitopes;Evaluation;Frequencies;Future;Heterogeneity;HIV vaccine;HIV-1;Human;Immunization;Immunize;immunogenic;improved;In Vitro;Individual;Keyhole Limpet Hemocyanin;Link;Modification;Monoclonal Antibodies;Mus;N-terminal;neutralizing antibody;nonhuman primate;novel;peptide vaccination;Peptides;Phase II Clinical Trials;Plasma;polyclonal antibody;Polysaccharides;protein aminoacid sequence;Reproducibility;Research Design;response;Science;Serum;Site;Structure;Testing;vaccination strategy;Vaccine Design;Variant;Venezuelan;Venezuelan Equine Encephalitis Virus;Virus;Virus-like particle;Western Equine Encephalitis Virus

PROJECT_TITLE: HIV-1 Fusion Peptide-directed Vaccine Design Using Virus-like Particles

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


PROJECT_TERMS: Address;Antibiotics;Appearance;Archives;autism spectrum disorder;Cecum;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;Colitis;Collection;Colon;Communities;Complex;cost;CRISPR/Cas technology;Cryopreservation;Data;Derivation procedure;Development;Disease;effectiveness evaluation;effectiveness testing;egg;electrical property;Electroporation;Embryo;embryo cryopreservation;embryo quality;Embryo Transfer;Engineering;Environment;Evaluation;evidence based guidelines;expectation;Feces;Female;Fetus;Freezing;Future;Gastrointestinal Contents;Gene Transfer Techniques;Genetic;Genetic Engineering;genetic manipulation;genome editing;Germ-Free;Gnotobiotic;gut microbiota;Health;host microbiota;Human;Immune;improved;Individual;insight;interest;Intracolonic;light microscopy;male;Malignant Neoplasms;Methods;Microbe;microbial community;microbial host;microbiome;microbiota;Mission;Morphology;mouse model;Mouse Strains;Mus;mutant;Mutant Strains Mice;Neurons;new technology;novel;Obesity;Oocytes;operation;Operative Surgical Procedures;Oral;Outcome;Pathway interactions;Performance;Phenotype;Play;preclinical study;prevent;Printing;Procedures;process improvement;Protocols documentation;public repository;Quantitative Evaluations;Recovery;regional difference;repository;Reproducibility;Research;Research Personnel;Research Project Grants;Resources;Role;sensor;Services;Small Intestines;Standardization;Sterility;Stomach;Superovulation;Technology;Testing;Time;Training;Transplantation;Upper digestive tract structure;Variant;Vasectomy;Visual;Wild Type Mouse;Work;zygote

PROJECT_TITLE: Research Projects #1 and #2


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Reduced T cell mediated immunity is a prominent feature of aging with important clinical consequences and is partially driven by diminished thymic function and altered naïve T cell development. Recent evidence suggests heterogeneity amongst naïve T cells that are generated during different developmental windows, but little is known about the intrathymic crosstalk that imprints naïve T cell character. This proposal focuses on understanding the novel role of epithelial-derived IL-13 in establishing medullary thymic function during early adulthood and how these pathways change during thymic aging, which may inform efforts to protect existing thymic function or reverse thymic involution to maximize T cell mediated immunity in the elderly.

PI_NAMEs: MILLER, COREY NICHOLAS (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Adult;Advisory Committees;Affect;Age;Aging;Antigens;arginase;Biology of Aging;career;career development;Cell Compartmentation;Cell Survival;Cells;Cellular biology;Cellular Immunity;Clinical;Communicable Diseases;Communities;cytokine;Data;Development;Development Plans;Doctor of Philosophy;Educational workshop;Elderly;emerging adult;Emigrant;Ensure;Environment;eosinophil;epigenome;Epithelium;Flow Cytometry;Foundations;Frequencies;Functional disorder;Future;genome-wide;Goals;Growth;Hematopoietic;Heterogeneity;Homeostasis;Host Defense;Human;IL7 gene;Immune;immune restorative treatment;Immunity;Immunofluorescence Immunologic;Immunology;imprint;Institution;interest;Interleukin-13;interleukin-13 receptor;Investigation;ITGAM gene;ITGAX gene;K-Series Research Career Programs;knowledge base;Licensing;Life;life span;Link;LoxP-flanked allele;Mediator;medical schools;Mentors;Mentorship;Mesenchymal;Mesenchyme;Metabolic;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Myelogenous;Myeloid Cells;Nature;novel;old mice;Output;Pathway interactions;Peripheral;polarized cell;post-doctoral training;Production;Productivity;programs;Proteins;Publications;Research;Research Institute;Research Proposals;Residencies;response;Role;Shapes;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Sorting;Source;Stains;Stromal Cells;Structure of thymic medulla;symposium;System;T-Cell Development;T-Lymphocyte;Technical Expertise;Thymic epithelial cell;thymocyte;Thymocyte Development;Thymus Gland;Tissues;Training;Tumor Immunity;Vaccination;verdin photosensitizer;Work;young adult;Youth

PROJECT_TITLE: Mechanisms of thymic stromal-immune crosstalk for homeostasis and naïve T cell licensing across life

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Biological Aging Study Section[NIA-B]


NIH_SPENDING_CATS: Genetics

PROJECT_TERMS: Address;Alleles;Alzheimer's Disease;Archives;aspirate;base;Bioinformatics;Biomedical Research;Blindness;brain tissue;Cardiovascular system;Censuses;Communities;Complement;cost;cost effective;cost efficient;Costs and Benefits;Data;Deposition;design;Discipline;Distributional Activity;Ensure;Exhibits;expectation;Exposure to;Freezing;Fresh Tissue;Genetic;Glioblastoma;Goals;Growth;Harvest;Human Biology;human disease;Hypertension;interest;Investments;Knowledge;Laboratories;Liver;Malignant Neoplasms;metabolomics;Mission;Molecular;Molecular Analysis;mouse model;Mouse Strains;multiple omics;Mus;Muscle;mutant;mutant mouse model;Mutant Strains Mice;Obesity;Penetrance;Phenotype;pleiotropism;preservation;Procedures;Process;Proteomics;Protocols documentation;Reproducibility;Research;Research Personnel;Research Project Grants;research study;Resources;Risk;Role;Sampling;Scientist;Services;sexual dimorphism;skeletal tissue;Study models;Testing;Time;Tissues;transcriptomics;United States National Institutes of Health;Validation;Wild Type Mouse

PROJECT_TITLE: Research Project #3


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Orphan Drug;Rare Diseases;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: Persistent HPV infections alone are linked to ~ 4.5% of the total cancer incidence worldwide and there are no targeted therapies for HPV-related cancers. We have large body of literature highlighting the function of NRF2 in HPV- related cancers, however, we have a poor understanding of how NRF2 is activated in HPV-infected cells. In this proposal, we will determine the molecular mechanism by which HPV E1 activates NRF2 and the first high-resolution view of the KEAP1-E1 interface will pave the way for structure-based design of novel therapeutics targeting this critical interaction.

PI_NAMEs: BINNING, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Affinity Chromatography;antagonist;Binding;biological adaptation to stress;Biological Assay;Biology;Biophysics;cancer cell;Cell Nucleus;Cell Survival;Cells;Chronic;Complex;CUL3 gene;Cytoplasm;Data;design;Drug Targeting;Enzymatic Biochemistry;experimental study;Failure;Genes;Genetic Transcription;global health;Goals;Head and Neck Cancer;helicase;high risk;HPV positive;HPV-negative head and neck cancer;Human papilloma virus infection;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16 E1 protein;In Vitro;Incidence;Inhibition of Apoptosis;inhibitor;insight;Knowledge;Link;Literature;Low risk HPV;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Mediating;Metabolism;Metastatic Neoplasm to Lymph Nodes;migration;mimetics;Molecular;mutant;Mutation;Mutation Analysis;new therapeutic target;novel;novel therapeutics;NQO1 gene;oral HPV-positive head and neck cancers;overexpression;Oxidative Stress;pathogen;Pathogenesis;Pathology;Pathway interactions;patient subsets;Phenocopy;Phenotype;Positioning Attribute;Prognostic Marker;Proliferating;Proteins;Regulation;Reporter;Resolution;Role;Signal Transduction;Solid Neoplasm;structural biology;Structure;Structure-Activity Relationship;targeted treatment;Testing;Therapeutic;treatment comparison;tumor;tumorigenesis;ubiquitin-protein ligase;Viral;Viral Pathogenesis;Viral Proteins;Virus;Virus Replication;Work;young adult

PROJECT_TITLE: The role of HPV E1 in regulating the NRF2-KEAP1 pathway

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: CHEMISTRY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: In this proposal we seek to characterize a novel effector from the pathogenic bacteria Legionella pneumophila, the causative agent of Legionnaires’ disease. We will explore the mechanism of action of the effector and its host targets in order to define certain aspects of molecular basis of L. pneumophila infection. We believe our work will pave the way for an improved understanding of the bacterial pathogenesis and creation of novel antimicrobial agents for the benefit of human health.

PI_NAMEs: DAS, CHITTARANJAN  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TITLE: DeADP-ribosylation of host targets mediated by a bacterial effector

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health as about 1 in 8 women in the U.S. will be diagnosed with breast cancer in her lifetime, and about 3 in 4 of those women will experience clinically significant sexual morbidity. Relevant to the mission of the NCI, this study aims to improve cancer care by establishing an Internet intervention that provides breast cancer survivors the greatest sexual health benefit for the least burden. Findings will also improve cancer-related sexual morbidity intervention science by evaluating how intervention components work, for whom they work best, and how they can be made more engaging.

PI_NAMEs: SHAFFER, KELLY MCLEAN (contact)

PROGRAM_OFFICER_NAME: MOLLICA, MICHELLE A

PROJECT_TERMS: Address;adjuvant endocrine therapy;Affect;animation;Behavioral;biopsychosocial;Breast Cancer survivor;Breast Cancer Treatment;cancer care;Cancer Control;Cancer Survivor;Caring;clinically significant;Communication;Community Clinical Oncology Program;Data;Development;Diagnosis;Disease;Distress;Dropout;Education;Electronic Mail;Emotional;Exercise;experience;Functional disorder;Goals;Guidelines;Health Benefit;Healthcare;improved;Individual;innovation;Internet;Intervention;Intervention Studies;intimate behavior;Knowledge;Learning;Malignant Breast Neoplasm;Malignant Neoplasms;Mediation;Mediator;Menopausal Status;Methodology;Mission;Morbidity - disease rate;multiphase optimization strategy;National Cancer Institute;novel;Outcome;Participant;Population;preference;primary outcome;Privacy;programs;Provider;psychoeducation;psychologic;psychological distress;psychosocial;Public Health;Qualitative Research;Randomized;recruit;Reporting;Research;Resources;satisfaction;Science;secondary outcome;Self Efficacy;Sex Functioning;Sexual Health;sexual health intervention;Site;skills;social stigma;Survivors;survivorship;Techniques;Testing;Therapeutic;Time;Training;usability;Woman;Work

PROJECT_TITLE: Optimizing psychosocial intervention for breast cancer-related sexual morbidity: A factorial trial using the National Cancer Institute Community Oncology Research Program (NCORP) network

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Lung;Pediatric

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: Project Narrative: The Children’s National Stimulating Access to Research in Residency (CNStARR) Program is a rigorous mentored program of career development and research training for pediatric residents from Children’s National Hospital and internal medicine residents from the George Washington University. CNStARR expands our existing capacity to recruit and retain outstanding pediatric and internal medicine residents with demonstrated potential and interest in pursuing research careers in content areas of interest to the National Heart, Lung, and Blood Institute (NHLBI), particularly in the areas of asthma and airway disease, congenital heart disease, and hematology and immunology. The overall goal of CNStARR is to develop independent clinician-investigators and academic leaders in scientific domains of relevance to NHLBI.

PI_NAMEs: HAHN, ANDREA LEIGH (contact)

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: Acceleration;Acute;Address;African American population;Airway Disease;Appointment;Area;Asthma;Award;Basic Science;career;career development;Child;Child Health;Childhood;clinical practice;Clinical Research;Clinical Sciences;clinical training;Collaborations;Competence;congenital heart abnormality;Data;Development Plans;Dimensions;Disparity;Doctor of Philosophy;Education;Elements;Enrollment;Environment;Etiology;experience;Face;Faculty;Feedback;flexibility;Fostering;Funding;Future;Goals;graduate medical education;Grant;Heart Diseases;Hematological Disease;Hematology;Hispanic Populations;Hospitals;Human;Immunology;Individual;Infant;Infrastructure;Institution;institutional capacity;interest;Internal Medicine;Investigation;K-Series Research Career Programs;Laboratories;Leadership;life span;Link;Lung Diseases;Medicine;Mentored Clinical Scientist Development Program;Mentors;National Heart, Lung, and Blood Institute;Outcome;Participant;Pediatric cohort;Pediatric Hospitals;pediatrician;Pediatrics;Performance;Physicians;pre-doctoral;Production;programs;Publishing;Ramp;recruit;Reporting;Research;Research Institute;Research Personnel;Research Project Grants;Research Technics;Research Training;Residencies;Resources;responsible research conduct;Scientist;Series;synergism;Time;Training;Training Programs;Translational Research;undergraduate medical education;United States National Institutes of Health;Universities;Wages;Washington;Woman;working group

PROJECT_TITLE: Children’s National Stimulating Access to Research in Residency (CNStARR) Program (NHLBI)


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Neurosciences;Nutrition

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: The sympathetic nervous system controls many important functions in the heart, including metabolism, through alpha-1 and beta-adrenergic receptors. In this proposal, we will pursue our novel preliminary data to determine whether and how alpha-1A adrenergic receptors regulate fatty acid oxidation and oxidative phosphorylation to provide energy for the heart. We also will continue our ongoing exploration of whether drugs that activate alpha-1A adrenergic receptors might be effective treatments for heart failure, a condition in which the heart has an insufficient supply of energy.

PI_NAMEs: JENSEN, BRIAN C (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Adrenergic Receptor;Agonist;alpha-1 adrenergic receptors;antagonist;Anthracycline;aorta constriction;Bioenergetics;Cardiac;Cardiac Myocytes;cardiometabolism;Cardiomyopathies;cardioprotection;Carnitine;Cell Death Induction;Cell Respiration;Chronic;Clinical;clinically relevant;Complex;Consumption;Coupled;Coupling;Data;Defect;diagnostic platform;differential expression;Duchenne muscular dystrophy;effective therapy;Electron Transport;Energy Supply;enzyme activity;Enzymes;Exhibits;experimental study;fatty acid oxidation;Functional disorder;gain of function;Heart;Heart failure;High Fat Diet;Impairment;In Vitro;in vivo;Infusion procedures;Injury;interest;Isoproterenol;Knock-out;Knockout Mice;lipidomics;long chain fatty acid;loss of function;Maintenance;Measures;Mediating;Mediator;Metabolic;Metabolism;Mitochondria;Modeling;mouse model;Mus;Muscle Fibers;Muscle Mitochondria;Myocardial;Myocardial Infarction;Myocardium;Nervous System control;novel;Organ;Oxidative Phosphorylation;Palmitates;Pathologic;Permeability;Pharmaceutical Preparations;Physiological;preservation;prevent;Proteins;Proteomics;Publishing;Receptor Activation;Receptors, Adrenergic, beta-1;Regulation;Research Personnel;Resolution;Skeletal Muscle;Spirometry;stable isotope;Sympathetic Nervous System;Testing;Toxic effect;Transferase;Treatment Failure

PROJECT_TITLE: Metabolic mechanisms of cardioprotection through alpha-1A adrenergic receptor activation

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Infectious Diseases;Neurosciences

ORG_CITY: COLLEGE PARK

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Project Narrative  Cryptococcus neoformans is a pathogenic fungus that causes fatal meningoencephalitis in immunocompromised individuals including HIV/AIDS patients. In this project, we will study the dynamic interactions between C. neoformans and mononuclear phagocytes in the brain in vivo. The study will facilitate the development of therapeutic strategies aimed at clearance of fungal infection in the brain by targeting brain mononuclear phagocytes.

PI_NAMEs: SHI, MEIQING  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Accounting;Animal Model;Animals;Autopsy;Blood;Blood - brain barrier anatomy;blood-brain barrier crossing;Bone Marrow;Brain;brain parenchyma;brain tissue;Cell Communication;Cells;Central Nervous System;Cessation of life;Clinical;Clinical Data;Complex;Cre lox recombination system;Cryptococcosis;Cryptococcus;Cryptococcus neoformans;Cryptococcus neoformans infection;Data;Dendrites;Dendritic Cells;Disease;Disease Progression;Effector Cell;Emigrations;Exhibits;fungicide;fungus;Genetic Engineering;Growth;HIV/AIDS;Host Defense;Human;Immune;Immune system;Immunocompromised Host;In Vitro;in vivo;Individual;Infection;Inflammatory;Inhalation;insight;intravital microscopy;Invaded;ITGAM gene;Life;Lung;Lung infections;Macrophage;Mediating;Meningoencephalitis;Microbe;Microglia;migration;monocyte;Mononuclear;mortality;Mus;mutant;Mycoses;Nerve;novel;Outcome;pathogen;Pathogenesis;pathogenic fungus;Patients;Persons;Phagocytes;Phagocytosis;Play;Population;prevent;Publishing;reconstitution;recruit;Rest;Role;System;Therapeutic;therapeutic development;Tissues;Work;Yeasts

PROJECT_TITLE: Interactions of Cryptococcus neoformans with mononuclear phagocytes in the brain

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ORG_CITY: NEW YORK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Structured RNA elements are essential for viability and virulence of pathogenic bacteria and viruses and therefore represent attractive targets for small molecule drugs. Massive ongoing efforts are focused on identifying RNA-targeting small molecules by high-throughput screening and functional assays; however, the binding of the candidate molecules to RNA cannot be directly assessed in vivo. We propose to develop a novel methodological approach for capturing and identifying small molecules that bind to the RNA in vivo, in live bacterial cells, and apply this method for finding cognate ligands for non-coding RNAs in pathogenic bacteria.

PI_NAMEs: QUARTA, GIULIO ;SERGANOV, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Address;Affinity;Affinity Chromatography;Aminoglycoside Antibiotics;Antibiotics;aptamer;Bacillus subtilis;Benchmarking;Binding;Biochemical;Biological Assay;Biological Models;Biophysics;Cell Extracts;Cell Physiology;Cells;Chemicals;Clinical;Clinical Research;Complex;complex data;Data;Development;Drug Targeting;efficacy evaluation;Elements;Ensure;Escherichia coli;experimental study;Fishes;Gene Expression;Genes;genetic information;Goals;Helicobacter pylori;high throughput screening;Human;human disease;human pathogen;In Vitro;in vivo;Infection;Infectious Agent;interest;Isotope Labeling;lead optimization;Ligand Binding;Ligands;Mammalian Cell;Mass Spectrum Analysis;Medicine;Messenger RNA;Metabolic;Methodology;Methods;Mutation;novel;novel strategies;Oligonucleotides;Orphan;pathogen;pathogenic bacteria;pathogenic virus;Pharmaceutical Preparations;Play;preclinical study;Procedures;Process;Production;protein complex;Proteins;Research Personnel;Ribosomal RNA;RNA;RNA Binding;RNA purification;RNA Viruses;Role;small molecule;Small RNA;Staphylococcus aureus;Structure;success;Therapeutic;Time;transcriptome;Untranslated RNA;viral RNA;Virulence;Virus

PROJECT_TITLE: Novel approach to identify RNA-bound small molecules in vivo

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE. Genome instability is one of the critical drivers of normal and premature aging. This proposal aims to dissect the role(s) of genome maintenance by the Werner syndrome helicase (WRN) and to determine how the loss of WRN results in the accelerated aging phenotypes found in Werner syndrome (WS) patients. Successful completion of the proposed aims will provide a deeper insight into the pathophysiology of WS and WRN’s roles in preventing genome instability and cellular senescence during normal aging .

PI_NAMEs: SONIAT, MICHAEL  (contact)

PROJECT_TERMS: Acceleration;age acceleration;Age related pathologies;age-related disease;Aging;aging related;aging related disease;Architecture;Award;Binding;Binding Proteins;Biochemical;Biochemistry;Biological;Biological Models;Biology;biophysical properties;biophysical techniques;Biophysics;Bloom Syndrome;career;Cell Aging;Cell Line;Cells;Cellular biology;Complex;Cryoelectron Microscopy;cytokine;Data;Dedications;Disease;DNA;DNA Damage;DNA Repair;DNA Repair Enzymes;DNA Repair Pathway;DNA Structure;early onset;exodeoxyribonuclease;Exonuclease;Family;Foundations;Functional disorder;Future;G-Quartets;Genes;Genome;genome integrity;Genome Stability;Genomic Instability;Goals;hallmarks of aging;helicase;Hereditary Disease;Heritability;Human;Human Biology;Immune signaling;Individual;Inflammation;Inflammatory;Insecta;insight;Institution;interdisciplinary approach;Interferons;Length;Maintenance;Malignant Neoplasms;Mentors;Microscopy;Molecular;Molecular Biology;Monitor;mutant;Mutation;Negative Staining;normal aging;nuclease;Outcome;overexpression;Pathology;Pathway interactions;Patients;Phase;Phenotype;Play;Positioning Attribute;post-doctoral training;premature;Premature aging syndrome;prevent;PRKDC gene;programs;Proteins;recruit;Repair Complex;replication factor A;Research;Resolution;Role;senescence;sensor;Signal Transduction;single molecule;Single-Stranded DNA;Stimulator of Interferon Genes;structural biology;Structure;Syndrome;telomere;telomere loss;tenure track;Testing;Training;TREX1 gene;Werner Syndrome;Work

PROJECT_TITLE: Molecular mechanisms of Werner syndrome helicase in genome stability and aging

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Pediatric;Rare Diseases;Tuberculosis

ORG_CITY: NIJMEGEN

ORG_COUNTRY: NETHERLANDS

ORG_FIPS: NL

ORG_NAME: STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM I.O.

PHR: Project Narrative Tuberculous meningitis (TBM) disproportionally affects young children as the most lethal form of tuberculosis. INTERCEPT aims to better understand the biological pathways that determine death or survival from TBM, both in children and adults, and how they might be manipulated therapeutically with better-directed or novel host directed therapeutic strategies.

PI_NAMEs: THWAITES, GUY ;VAN CREVEL, REINOUT  (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Address;Adjuvant;Adjuvant Therapy;Adult;Affect;Aspirin;Biological;biomarker identification;Blood;Blood brain barrier dysfunction;Brain Death;Brain Infarction;Cells;Central Nervous System;Cerebral Edema;Cerebrospinal Fluid;Cessation of life;Characteristics;Child;Childhood;Clinical;clinical phenotype;Clinical Research;Cognitive;cohort;Collaborations;Data;Development;Disease;Disease Outcome;Enrollment;Enzymes;Family;Funding;Future;Genetic;genomic biomarker;genomic data;Genotype;immune function;immunopathology;Indonesia;Inflammation Mediators;Inflammatory;inhibitor;Intercept;Link;Lipids;Long term disability;Matrix Metalloproteinases;Measures;Meningeal Tuberculosis;Metabolic Pathway;Metabolism;metabolome;metabolomics;Metalloproteases;Morbidity - disease rate;mortality;multiple omics;Mycobacterium tuberculosis;new therapeutic target;novel;novel therapeutic intervention;Nutrient;Outcome;Pathogenesis;Pathway interactions;Patients;pediatric patients;Phase III Clinical Trials;phenotypic data;predictive marker;Proteomics;Quantitative Trait Loci;randomized trial;Randomized, Controlled Trials;Role;Sampling;Severities;Severity of illness;stromelysin 2;survival prediction;Testing;Therapeutic;Therapeutic Effect;Tissue Inhibitor of Metalloproteinases;Tissues;trait;Tryptophan;Tryptophan Metabolism Pathway;Tuberculosis;Vietnam;Work

PROJECT_TITLE: INTERCEPT

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Our long-term goal is to understand the rules governing how endothelial cells (EC), vascular smooth muscle cells (VSMC) and sympathetic neurons (SN) interact within the formation of an artery. Through these rules, SN and VSMC maintain a privileged relationship with the arterial vasculature throughout the life of all vertebrates.

PI_NAMEs: NICOLI, STEFANIA  (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Address;Adult;Affect;Animals;Aorta;Area;Arteries;Basic Science;Biological Assay;biophysical techniques;Biophysics;Blood flow;Blood Pressure;blood vessel development;Blood Vessels;Body Temperature;candidate identification;Cardiovascular Pathology;Cardiovascular system;cell behavior;Cell Physiology;cell type;Cells;Circulation;Coculture Techniques;Collaborations;Complex;Congenital Abnormality;Congenital Cardiovascular Abnormality;congenital heart abnormality;constriction;Data;Defect;Dependence;Disease;Dorsal;Embryo;Embryonic Development;Endothelial Cells;Event;Experimental Designs;Functional disorder;Genes;Genetic;genetic manipulation;Goals;hemodynamics;Hemorrhage;Homeostasis;Human;human model;Image;imaging approach;improved;In Vitro;in vivo;Individual;Knowledge;Life;Link;live cell imaging;Maintenance;Maps;Mediating;Metabolism;Microfluidics;microscopic imaging;migration;Modeling;Molecular;Morphogenesis;mouse model;Mus;nerve stem cell;nerve supply;neuron component;Neuronal Differentiation;Neurons;neurovascular;neurovascular coupling;neurovascular unit;novel;Oxygen;Paracrine Communication;Pathway interactions;Patients;Persons;Phenotype;Physiological;postnatal;programs;Proliferating;Regulation;repaired;Research Personnel;Respiration;Science;shear stress;Signal Pathway;Signal Transduction;Smooth Muscle Myocytes;stem;Sympathetic Nervous System;System;Testing;Therapeutic;Tissues;Translating;Vascular Endothelial Cell;Vascular remodeling;Vascular Smooth Muscle;Vascular System;Vertebrates;Work;Zebrafish

PROJECT_TITLE: Defining the cellular and molecular formation of the sympathetic neurovascular unit

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurodegenerative;Neurosciences

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE The thalamus and its subdivisions called nuclei play a critical role not only as a relay to the cerebral cortex but also in memory, emotion, consciousness, and arousal and have been implicated in many neurological and psychiatric disorders. Thalamic nuclei are not easily visualized in conventional MRI and specialized methods proposed for visualization and segmentation of thalamic nuclei are still not accurate, especially for small nuclei. The novel methods for improved visualization and automated segmentation of thalamic nuclei developed in this grant will help identify biomarkers with high sensitivity and specificity to be used in future studies for the identification, evaluation, and monitoring of treatment strategies in different conditions like Alzheimer’s disease, schizophrenia, and essential tremor.

PI_NAMEs: SARANATHAN, MANOJKUMAR  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Age;age stratification;alcohol use disorder;alertness;Alzheimer's Disease;Alzheimer's disease patient;Arousal;Atlases;Atrophic;autism spectrum disorder;automated segmentation;biomarker identification;Cell Nucleus;Cerebral cortex;cohort;Conscious;contrast imaging;convolutional neural network;Data;Databases;Deep Brain Stimulation;deep learning;Development;diffusion anisotropy;Diffusion Magnetic Resonance Imaging;Disease;Echo-Planar Imaging;Emotions;Episodic memory;Essential Tremor;Evaluation;Evaluation Studies;Functional Magnetic Resonance Imaging;Future;Grant;gray matter;healthy aging;Image;image processing;imaging biomarker;imaging modality;imaging study;improved;Individual;Knowledge;Magnetic Resonance Imaging;Manuals;Memory;Mental disorders;Methods;mild cognitive impairment;Monitor;Motion;Motor;Multiple Sclerosis;Nervous System Disorder;Nervous System Physiology;Network-based;Neurodegenerative Disorders;neuroimaging;new therapeutic target;next generation;normal aging;novel;Nuclear;open data;Parkinson Disease;Pathology;Phase;Physiologic pulse;Play;Population;Predisposition;Public Domains;reconstruction;Regulation;Resolution;Rest;Role;Scheme;Schizophrenia;Sensitivity and Specificity;Sensory;Series;Signal Transduction;Sleep;Speed;Stroke;structural imaging;Techniques;Testing;Thalamic Nuclei;Thalamic structure;Therapeutic;Time;Traumatic Brain Injury;treatment strategy;Visualization;white matter;Work

PROJECT_TITLE: Next-Generation Thalamic Nuclei Visualization and Segmentation Methods

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Estrogen;Neurosciences;Substance Misuse;Tobacco;Women's Health Research

ORG_CITY: EL PASO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF TEXAS EL PASO

ORG_STATE: TX

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the findings are expected to constitute an important step toward elucidating the larger neuronal substrates that promote addiction pathology in women. The proposed studies are relevant to the part of the NIH mission that pertains to supporting research aimed at reducing the burden of substance use disorders, especially in women who are most vulnerable to the long-term negative health consequences of chronic nicotine use.

PI_NAMEs: ODELL, LAURA ELENA (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: addiction;Adult women;anxiety-like behavior;base;Behavior;Behavioral;biological adaptation to stress;Chronic;Clinical;Corticotropin-Releasing Hormone;Data;design;Development;Economics;electronic cigarette use;Electronic Nicotine Delivery Systems;Epidemic;Estradiol;Evidence based intervention;experience;Female;Future;gamma-Aminobutyric Acid;Gene Transfer;Goals;Gonadal Hormones;Habenula;Health;Hormones;Human;immunocytochemistry;improved outcome;Inhalation;innovation;insight;interdisciplinary approach;Interneurons;interpeduncular nucleus;Intervention;Knowledge;Learning;Literature;male;Measures;Medial;Mediating;men;Methods;Mission;negative affect;neurochemistry;Neurons;Neurotransmitters;Nicotine;nicotine exposure;nicotine use;nicotine vapor;Nicotine Withdrawal;novel;Outcome;Ovarian hormone;Pathology;Pathway interactions;Peptides;Pharmaceutical Preparations;Play;Population;Precision therapeutics;Predisposition;Production;Progesterone;programs;Public Health;Rattus;receptor;receptor expression;Reduce health disparities;Reporting;Research;Research Support;Rodent;Severities;sex;Sex Differences;Stress;Substance Use Disorder;System;Technology Transfer;Tobacco use;United States National Institutes of Health;Withdrawal;Withdrawal Symptom;Woman;women versus men;Work

PROJECT_TITLE: Sex Differences and The Influence of Ovarian Hormones on the Mechanisms that Promote Nicotine Withdrawal

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Cancer;Patient Safety

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Summary The Clinical Trial Concept in the Oncology Landscape (CTC) is a virtual and in-person, hybrid course designed to educate oncology trainees and junior faculty from any cancer specialty in applying Good Clinical Practice (GCP) and scientific reasoning into effective clinical trial design. The course will accept junior oncologists and fellows/residents in an oncology specialty, who are novice in cancer clinical research. The course will deliver in Part 1, The Fundamentals of Clinical Research, a semester long virtual immersive educational experience across all areas of cancer clinical research, then culminate in an in-person Trial Concept Writing Camp (Part 2) during the annual American Association of Cancer Institute (AACI) Clinical Research Innovation (CRI) meeting where participants will be mentored by experienced clinical investigators from different AACI member institutions during which time, they will finalize a clinical trial concept (also called letter of intent (LOI)), the end product of this course. Participants are selected through a competitive application process consisting of a CV, personal statement, letter of support from a local clinical research mentor, and a career development plan. Accepted participants will first receive scientific and GCP training over 20 virtual sessions covering the 6 major modules of protocol development that encompass the eleven domains of clinical trial expertise, including oncology, science, medicine, business/negotiation, accounting, statistics, pharmacy, pharmacology, laws and regulations, ethics, and clinical trial management. The curriculum will be loaded on a web portal developed for educational purposes under another U24 NCI award to OSUCCC. The virtual training will use a flipped classroom approach to maintain participant attentiveness. At the CRI meeting, participants will interact with Key Faculty mentors, nationwide experts in clinical research, who will help them complete a realistic concept form that meets scientific standards. Participants will take part in pre- and post-tests to determine the cogency of the CTC curriculum for their professional practice, and the effectiveness of the course logistics. They will complete the course by submitting a finalized clinical trial concept to the CTC course directors. Afterwards, they should be able to use their concept to develop a full protocol at their own institutions or though the NCI clinical research networks or other clinical trial networks. After the course, public data will be used to track participants’ career trajectories to determine the long-term effects of the course on their careers, working with Academics Analytics, a company contracted with OSU. Impact. Investigators must apply GCP and the International Conference on Harmonisation (ICH) guidelines to the design and scientific approach of their clinical research. The basics of clinical research are not taught in medical schools or residencies. The pool of clinical investigators has also decreased in the US, creating a serious shortage of clinical trial experts. At the same time, there has been an explosion of biological discoveries and technological advances. This innovative and necessary CTC course will address the need for thorough and specific training on clinical trial design and execution to eventually benefit patients with cancers and support the professional development of junior oncology faculty.

PI_NAMEs: OWEN, DWIGHT H.;VERSCHRAEGEN, CLAIRE F. (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Accounting;Advocate;Area;Association of American Cancer Institutes;Award;Basic Science;Biological;Businesses;cancer clinical trial;Cancer Therapy Evaluation Program;career;career development;career networking;Caring;Clinical;Clinical Investigator;Clinical Management;Clinical Research;Clinical Trials;Clinical Trials Design;Clinical Trials Network;Code;Collaborations;Comprehensive Cancer Center;Conflict of Interest;Contracts;Data;Data Analyses;Data Collection;design;Development;Development Plans;E-learning;Economics;Education;educational atmosphere;Educational Curriculum;Educational process of instructing;Effectiveness;Elements;Environment;Ethics;Evaluation;Exercise;experience;Explosion;Faculty;faculty mentor;flipped classroom;Funding;Goals;Good Clinical Practice;Guidelines;Health;higher education;Hybrids;Infrastructure;innovation;Institution;Institutional Review Boards;interest;International;Intervention;Laws;Learning;Learning Module;lectures;Legal;Letters;Logic;Logistics;Long-Term Effects;Malignant Neoplasms;Marketing;Measures;Mediation;Medical Residency;medical schools;medical specialties;Medicine;meetings;member;Mentors;Methods;Modeling;Monitor;multidisciplinary;next generation;Ohio;Oncologist;Oncology;Outcome;Participant;patient engagement;Patients;Persons;Pharmacologic Substance;Pharmacology;Pharmacy facility;Process;Professional Practice;programs;protocol development;Protocols documentation;Publications;recruit;Regulation;Research;Research Design;research faculty;Research Personnel;Safety;Schedule;Science;secondary endpoint;Series;skill acquisition;sound;statistics;success;Surveys;symposium;System;Technology;Testing;Time;tool;Training;Universities;virtual;web portal;Writing

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Congenital Structural Anomalies;Immunotherapy;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Primary Immunodeficiencies;Rare Diseases

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: A growing appreciation of the clinically relevant interactions between the brain and the immune system has reshaped our understanding of the pathophysiology of mental disorders while providing new insights into their prevention and treatment. This proposal addresses how the brain vasculature interacts with the immune system to impact the brain and behavior during development and in response to an environmental “second hit; all in the context of a condition closely replicating neuropsychiatric disorders, the 22q11.2 deletion syndrome. We propose to correct these abnormalities by interventions targeting dysfunction within the brain-immune axis.

PI_NAMEs: ALVAREZ, JORGE IVAN (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Abate;Address;Adolescence;Adult;Affect;autism spectrum disorder;Automobile Driving;Behavior;behavior influence;Behavioral;behavioral impairment;behavioral outcome;Biological Response Modifiers;Blood - brain barrier anatomy;blood-brain barrier disruption;blood-brain barrier function;Brain;Central Nervous System;Cerebrovascular system;Childhood;Clinic;Clinical;clinical phenotype;clinically relevant;Communication;Competence;cytokine;Data;Development;DiGeorge Syndrome;Disease;disease model;Environment;environmental stressor;Exhibits;Functional disorder;Genes;Genetic Predisposition to Disease;Goals;Hippocampus;Human;human model;IL17 gene;Immune;Immune system;Immune System Diseases;Immune Targeting;immunodeficiency;Immunotherapeutic agent;Immunotherapy;Impairment;improved;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;insight;Interleukin-1 beta;Interleukin-6;Intervention;Lead;Link;Lipopolysaccharides;Mediating;Memory;Mental Depression;Mental disorders;Modeling;mouse model;Mus;Neuroimmune;neuroinflammation;Neurons;neuropsychiatric disorder;neuropsychiatric symptom;neuropsychiatry;neurovascular;Ontology;Outcome;Pathogenicity;Patients;Peripheral;Phenotype;Predisposition;prevent;Prevention;preventive intervention;Process;Property;Research;response;Risk;Role;Schizophrenia;Science;Shapes;small molecule;social;social deficits;Stress;symptomatology;Symptoms;T cell response;T-Lymphocyte;Testing;Therapeutic;therapeutic target;Translating;undue influence;Work;young adult

PROJECT_TITLE: Role of the brain-immune axis in neuropsychiatric disease

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ED_INST_TYPE: HOSPITALS

ORG_CITY: TYLER

ORG_NAME: UNIVERSITY OF TEXAS HLTH CTR AT TYLER

PHR: PROJECT NARRATIVE Inflammation contributes to venous thrombosis, and suppression of inflammation may prevent or resolve venous thrombosis. The current proposal investigates the mechanism by which a newly identified inflammatory signaling pathway promotes venous thrombosis. The knowledge gained from our proposed studies will provide new insights into how inflammation contributes to thrombosis and aid in developing new drugs to treat venous thrombosis without increasing bleeding risk, a common problem associated with current anticoagulation therapy.

PI_NAMEs: LELLA, VIJAYA MOHAN RAO (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Adaptor Signaling Protein;Affect;Anticoagulant therapy;Anticoagulants;Anticoagulation;Attenuated;BCL10 gene;Binding Proteins;Blood;Blood flow;Blood Platelets;Blood Vessels;Cell Adhesion Molecules;cell type;Cells;Cessation of life;chemokine;Complex;Couples;Coupling;cytokine;Deep Vein Thrombosis;Development;Diagnosis;Docking;druggable target;Endothelial Cells;Endothelium;Endotoxins;Etiology;Event;Exocytosis;extracellular;Fibrosis;Functional disorder;Gene Expression;growth factor receptor-bound protein 2;Hemorrhage;IL1R1 gene;improved;in vivo;Infection;Inferior vena cava structure;Inflammation;Inflammatory;inhibitor;Injury;innovation;insight;Interleukin-1 beta;Knock-out;Knockout Mice;Knowledge;Leukocytes;Ligation;lung injury;Mediating;Mediator;Molecular;monocyte;Morbidity - disease rate;mortality;mouse model;Mucosa- associated lymphoid tissue lymphoma translocation protein-1;Mus;Myeloid Cells;Myocardial Infarction;neutrophil;NF-kappa B;novel;novel therapeutics;Oral;P-Selectin;Pathogenesis;Persons;Pharmaceutical Preparations;pharmacologic;Play;prevent;Process;Proteins;Publishing;Pulmonary Embolism;Resolution;response;rho;Risk;Role;Signal Induction;Signal Pathway;Signal Transduction;Signal Transduction Induction;Signal Transduction Pathway;Stimulus;Streptococcus pneumoniae;Stroke;structural determinants;Therapeutic;thrombogenesis;thromboinflammation;Thrombophilia;Thromboplastin;Thrombosis;Thrombus;Time;TLR4 gene;TNF gene;TNFRSF1A gene;Transgenic Mice;Veins;Venous;venous thromboembolism;Venous Thrombosis

PROJECT_TITLE: The Role  of Gab2-MALT1-mediated cell signaling in venous thrombogenesis

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: SEATTLE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative A crucial need exists for anesthesiology and perioperative medicine investigators with a broad range of theoretical, methodological, and technical knowledge. These attributes are required to advance scientific opportunities from basic, translational, behavioral, population and clinical sciences to novel applications that reduce the burden placed on patients and their families by pain, stress, and perioperative complications.

PI_NAMEs: PALERMO, TONYA M (contact)

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TITLE: Anesthesiology & Perioperative Medicine Training Grant

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-A (PD)]


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: Aurora

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Biomedical researchers are increasingly linking genome wide data with other omics data to understand the biological relevance and molecular processes underlying genome-wide association study signals. The Multi- Omics and NETwork analysis workshop (MONET) will provide a 7-day immersive experience for ~25 researchers each summer 2024-2028 to learn about multi-omics analysis and the application of network methods through ~50 hours of lectures, discussion sessions, computational labs, tours and team exercises.

PI_NAMEs: KECHRIS-MAYS, KATHERINA  (contact)

PROGRAM_OFFICER_NAME: HINDORFF, LUCIA

PROJECT_TERMS: Archives;Bioinformatics;Biological;biomarker identification;Caring;Chromatin;Clinical;Cloud Computing;Code;Colorado;Competence;Complement;Complex;Computer software;computerized data processing;Data;Data Analyses;data integration;Data Science;Data Set;data sharing;Diagnosis;digital repositories;Disease;disorder prevention;disorder subtype;diverse data;DNA;DNA Methylation;doctoral student;education research;Educational workshop;Electronic Mail;Enzymes;Ethics;Etiology;Evaluation;Exercise;experience;Familiarity;frontier;Generations;Genetic;genetic analysis;genome wide association study;genome-wide;Genomics;graduate student;Graph;Heterogeneity;Hour;industry partner;Infrastructure;insight;Institution;Instruction;instructor;interest;Intuition;Knowledge;Laboratories;Lead;Learning;lecturer;lectures;Link;Medical;Metabolic Pathway;Methodology;Methods;Mission;Modality;Molecular;molecular phenotype;multidimensional data;Multiomic Data;multiple omics;National Human Genome Research Institute;Noise;outreach;Participant;Pathway Analysis;Performance;Persons;Physiological;Policies;Postbaccalaureate;Postdoctoral Fellow;Preparation;Privacy;Procedures;Process;Program Evaluation;programs;Proteins;Publications;Race;recruit;Research;Research Design;Research Personnel;response;responsible research conduct;Rest;Role;Sampling;Science;senior faculty;Signal Transduction;skill acquisition;social media;Source;Surveys;System;Technology;Time;Tissues;tool;Training;trait;Trans-Omics for Precision Medicine;Transcript;Underrepresented Populations;Universities;Variant;web site

PROJECT_TITLE: Multi-Omics and NETwork Analysis Summer Workshop (MONET)

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-W (O1)]


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: 8. PROJECT NARRATIVE Vascular surgeons and scientists provide a practical “hands on” perspective on the relevant problems of devices and interventions on blood vessels. This medical student research program is designed to inspire and create a cadre of physician scientists with the basic tools, expertise and talent to pursue research careers essential to frontline ‘bench to bedside to public policy’ programs in treatment of vascular disease.

PI_NAMEs: FERRAN, CHRISTIANE ;LOGERFO, FRANK W (contact);PRADHAN-NABZDYK, LEENA

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: angiogenesis;Area;atherogenesis;Attention;Basic Science;Bioinformatics;Biomechanics;Blood Vessels;career;Cellular biology;Clinical;clinically relevant;Coagulation Process;Country;Evolution;experience;Faculty;Fostering;Goals;Hyperplasia;Individual;interdisciplinary collaboration;interest;Laboratories;lectures;Light;Medical;medical schools;medical specialties;Medical Students;meetings;Mentors;Mentorship;Minority;Molecular Biology;Operative Surgical Procedures;Outcome;Outcomes Research;Postdoctoral Fellow;programs;Prosthesis;Qualifying;Recording of previous events;Records;recruit;Research;Research Activity;Research Peer Review;Research Personnel;Research Project Grants;Research Training;responsible research conduct;Scientist;Students;Thrombosis;Time;Training;Training Programs;Woman;Work

PROJECT_TITLE: Harvard Longwood Short-Term Research Training in Vascular Surgery

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-B (O1)]


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: Raleigh

ORG_NAME: GLYCAN THERAPEUTICS CORPORATION

PHR: Project Narrative Heparin and low-molecular weight heparins (LMWHs) are mixtures of highly sulfated polysaccharides isolated from animal tissues. In this project, Glycan Therapeutics plans to use an innovative chemoenzymatic technology to synthesize heparin-like glycan. The project is designed to improve the safety of heparin drugs, and to reduce the cost of heparin synthesis.

PI_NAMEs: PAGADALA, VIJAYAKANTH  (contact)

PROJECT_TERMS: Affect;African;African Swine Fever Virus;Animal Sources;animal tissue;Animals;Anticoagulants;Antidotes;Applications Grants;Cessation of life;Chemical Structure;China;Classical Swine Fever;Clinical;Clinical Trials;Complex Mixtures;Congresses;cost;cost effective;COVID-19 pandemic;dalton;depolymerization;design;Development;Disease Outbreaks;Economics;Enoxaparin;Ensure;Epidemic;Family suidae;Formulation;Funding;Goals;Grant;Heparin;Human;Impairment;improved;innovation;Insulin;Intestines;Investigational Drugs;Kidney;Letters;Low-Molecular-Weight Heparin;manufacture;manufacturing process;Marketing;Medicine;meetings;Minor;Modernization;molecular mass;Natural Products;Nitrogen Dioxide;North Carolina;Pathway interactions;Patients;Penetration;Pharmaceutical Preparations;Pharmacodynamics;pharmacophore;Phase;Politics;Polysaccharides;Preparation;Production;Property;Protamines;Recombinants;Regulatory Pathway;Risk;Safety;Secure;Small Business Innovation Research Grant;success;Sulfate;supply chain;Technology;Therapeutic;Toxic effect;Work

PROJECT_TITLE: Development of dekaparin to replace animal-sourced heparin

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-F (O1)]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE Childhood obesity is a persistent epidemic in the United States, yet virtually no effective preventive strategies target the childcare setting where children eat 75% of their meals. ONE PATH will test the effect of adding responsive feeding and appetite regulation components to an existing, evidence-based program that intervenes on the childcare setting environment. The proposed research will evaluate whether ONE PATH increases responsive feeding in the classroom and home settings and promotes child awareness of their hunger/fullness to prevent overeating and unhealthy weight gain among families with children living in rural poverty.

PI_NAMEs: WILLIAMS, JENNIFER SAVAGE (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: 4 year old;5 year old;Academy;Address;Affect;American;Appetite Regulation;Area;attentional control;Awareness;Body mass index;Caregivers;Caring;Categories;Child;Child Care;Child Development;Child Rearing;Childhood;clinically significant;cohort;community setting;cost;cost effective;County;critical developmental period;Cues;Data;design;Desire for food;Development;E-learning;early childhood;Eating;economic disparity;Education;educational atmosphere;Educational Curriculum;Educational process of instructing;efficacious intervention;efficacy testing;Enrollment;Environment;Epidemic;Ethnic Origin;evidence base;Evidence based intervention;Evidence based program;Exercise;experience;experimental study;Family;feeding;food environment;Food Intake Regulation;food security;Fostering;Funding;Future;Goals;Growth;Head Start Program;Health Care Costs;high risk;Home;Home environment;Home visitation;Hunger;Hyperphagia;improved;Individual;Informal Social Control;Infrastructure;innovation;Intervention;intervention effect;Laboratories;Life;Low income;Maternal and Child Health;member;Methodology;Methods;mindfulness;Mission;Modeling;multi-component intervention;multidisciplinary;multiphase optimization strategy;National Institute of Diabetes and Digestive and Kidney Diseases;Nursery Schools;nutrition;nutrition education;Obesity;obesity development;obesity in children;obesity prevention;Outcome;Parenting Education;parenting intervention;Parents;Participant;Pediatrics;Pennsylvania;Physical activity;Play;Policies;Preschool Child;prevent;Prevention program;Prevention strategy;preventive intervention;primary outcome;programs;Provider;Public Health;Race;Randomized;Randomized, Controlled Trials;Recommendation;Recording of previous events;Regulation;Research;Research Personnel;response;Rural;rural area;rural counties;Rural Population;rural poverty;Sampling;School-Age Population;Schools;secondary outcome;Self Assessment;sex;Site;skills;Structure;Subgroup;teacher;Temperament;Testing;Training;Training and Education;Translating;treatment effect;Trust;underserved area;United States;United States National Institutes of Health;virtual;Vulnerable Populations;Weight;Weight Gain;Work

PROJECT_TITLE: ONE PATH: Optimizing Nutrition Education for Parents And Teachers for Healthy Growth

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-J(04)]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: PROJECT NARRATIVE Abdominal aortic aneurysm (AAA) is the most common aortic pathology and accounts for 10,000 deaths annually in the United States. This proposal investigates the development and use of peptide amphiphile nanofibers for targeting unique extracellular matrix features found in AAAs. This technology will serve as the foundation for a targeted therapeutic to prevent, diagnose, and/or regress AAA.

PI_NAMEs: LEDFORD, BENJAMIN  (contact)

PROJECT_TERMS: abdominal aorta;Abdominal Aortic Aneurysm;Agonist;Amino Acid Sequence;Aneurysm;Animal Behavior;Aorta;Aortic Aneurysm;Architecture;autoinflammatory;Bile fluid;Binding;Binding Proteins;Biodistribution;Biological Assay;biomaterial compatibility;Blood;Blood Chemical Analysis;Blood specimen;Brain;Cessation of life;Chronic Disease;Coagulation Process;Collagen;Complement Activation;Contrast Media;cytokine;Data;delivery vehicle;design;Development;Diagnosis;diagnostic platform;diagnostic tool;Diameter;Dimensions;Dose;effective therapy;Elastin;Epitopes;experience;experimental study;Exposure to;Extracellular Matrix;Fatty Acids;Female;Foundations;Functional disorder;Gelatinase A;Goals;Half-Life;Heart;In Vitro;in vivo;interest;Intervention;Intestines;Intravenous;intravenous administration;Kidney;Kinetics;Label;Laboratories;Length;Light;Link;Liver;Lung;male;Matrix Metalloproteinase Inhibitor;Matrix Metalloproteinases;Measures;Medial;Mentorship;Microscopy;MMP14 gene;Monitor;Mus;nanofiber;nanomaterials;nanoscale;Nanotechnology;nanotherapeutic;nile red;novel;Organ;overexpression;Pathology;peptide amphiphiles;Peptides;pharmacologic;Play;pre-clinical;prevent;Property;Rattus;Reader;Reporting;Research Personnel;Research Proposals;Roentgen Rays;Safety;safety assessment;Saline;Site;Skeletal Muscle;Specificity;Spleen;Sprague-Dawley Rats;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Agents;Time;Tissue Sample;Tissues;Transforming Growth Factor beta;Transmission Electron Microscopy;United States;United States National Institutes of Health;Up-Regulation;Urine;Weight

PROJECT_TITLE: Development of an Intravenously Delivered Nanofiber to Target MMP-2 in Aortic Aneurysms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F15-P(20)L]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Osteoporosis and related metabolic bone diseases impose serious health consequences on older adults, and heavy economic costs on public health systems in the United States. In this project we develop specialized MRI scanner technology targeted to more accurate diagnosis of osteoporosis and related metabolic bone diseases, and test this technology in animal and human studies.

PI_NAMEs: ACKERMAN, JEROME L (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: 3-Dimensional;accurate diagnosis;accurate diagnostics;Address;Age;American;animal tissue;Animals;arm;Biological;Biological Markers;bone;Bone Density;bone fragility;bone imaging;Bone Matrix;bone quality;Calibration;Capital;Cessation of life;Chemicals;Clinic;Clinical Data;Clinical Research;Clinical Trials;cohort;cost;Coupled;Data;Dedications;Deformity;density;design;design and construction;Development;Diagnosis;Diagnostic;diagnostic panel;Disease;Dual-Energy X-Ray Absorptiometry;economic cost;efficacy evaluation;Elderly;experimental study;fracture risk;fragility fracture;Funding;Future;Gender;Generations;Goals;Health;Health system;healthy volunteer;Human;Image;image reconstruction;Imaging Techniques;Ionizing radiation;Joints;Knowledge;Laboratories;Leg;Limb structure;Magnetic Resonance Imaging;Measurement;Measures;metabolic abnormality assessment;Metabolic Bone Diseases;Methodology;Methods;mineralization;Minerals;MRI Scans;network architecture;Noise;novel;older adult;Osteomalacia;Osteoporosis;Pain;Patients;Performance;Peripheral;Phosphorus;Physiologic pulse;Postmenopause;Protons;Public Health;Radiation Dose Unit;Radiation exposure;reconstruction;Renal Osteodystrophy;Resolution;RF coil;Safety;Scanning;screening;Serum;Signal Transduction;skeletal;Societies;soft tissue;Solid;solid state;Specimen;stem;Techniques;Technology;technology development;Testing;Time;United States;United States National Institutes of Health;Woman;Writing

PROJECT_TITLE: Bone Quality Assessment with a Novel Three-Bore Magnet Extremity MRI Scanner

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Bipolar Disorder;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Prevention;Serious Mental Illness;Suicide;Suicide Prevention;Violence Research

PHR: NARRATIVE In Bipolar Disorder, rates of suicide attempt and completed suicide are critically high; however, there are no existing medications that have been developed specifically to decrease the burden of suicide. Previous suicide attempt is a primary predictor of completed suicide; thus, there is a critical need to identify molecular mechanisms that underlie suicidal behavior in bipolar disorder, which could lead to new therapeutic targets for more effective treatments for suicidal behavior in both men and women. We propose an innovative approach using positron emission tomography brain scanning alongside symptom and cognitive assessments of individuals with bipolar disorder to study a novel target, the glutamatergic receptor mGluR5, which has been newly implicated in suicidal behavior in bipolar disorder.

PI_NAMEs: ESTERLIS, IRINA  (contact)

PROGRAM_OFFICER_NAME: LAWHORN, COLLENE

PROJECT_TERMS: Acute;Advisory Committees;Age;Animal Model;Autopsy;Behavior;Behavioral;Behavioral Mechanisms;Bipolar Disorder;Brain;Brain region;Brain scan;Chronic;cognitive process;cognitive testing;comparison control;comparison group;completed suicide;Data;design;Detection;Development;Disease;disorder risk;effective therapy;emotion regulation;endophenotype;Exhibits;experience;Face;Feeling suicidal;Functional disorder;Functional Magnetic Resonance Imaging;Genes;Glutamates;High Prevalence;high risk;improved;Impulsive Behavior;Impulsivity;in vivo;in vivo imaging;Individual;innovation;insight;interdisciplinary approach;Knowledge;Left;Life;Measures;men;Methods;Molecular;Molecular Target;monoamine;mood regulation;Moods;neural;neuromechanism;neurotransmission;new therapeutic target;novel;Patient Self-Report;Patients;Persons;Pharmaceutical Preparations;Play;Positron-Emission Tomography;pre-clinical;Prefrontal Cortex;Prevalence;Prevention;Proteins;Psychiatry;receptor;Recording of previous events;reducing suicide;Reflex action;Regulation;Research;Research Domain Criteria;response;reward processing;Rewards;Risk;Risk Reduction;Role;Scaffolding Protein;Severities;sex;Sex Behavior;Sex Differences;suicidal behavior;suicidal risk;Suicide;Suicide attempt;suicide attempter;suicide mortality;Suicide prevention;suicide rate;Symptoms;Synaptic plasticity;System;Time;trait;treatment strategy;Woman

PROJECT_TITLE: In vivo imaging of a neural marker of suicidal behavior in Bipolar Disorder

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Digestive Diseases;Liver Disease;Patient Safety

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Project Narrative Iatrogenic hypoglycemia is the most prominent barrier to the safe, effective management of blood sugar in people with type 1 diabetes due to periodic over-insulinization. During insulin-induced hypoglycemia, glucagon secretion is diminished in type 1 diabetes which, in turn, reduces hepatic glucose production and increases the depth and duration of hypoglycemic episodes. We have observed that the naturally occurring protein C-peptide increases glucagon secretion in dogs during insulin-induced hypoglycemia, which increases hepatic glucose production; the experiments in this application will shed light on the translation of this finding to the human.

PI_NAMEs: WINNICK, JASON  (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Abate;Address;Agreement;Beta Cell;Blood Glucose;blood glucose regulation;Blood Vessels;C-Peptide;canine model;Canis familiaris;Carbohydrates;Cell Physiology;Closure by clamp;comorbidity;Consumption;counterregulation;Data;diabetes control;Diagnosis;Disease;Dose;Epinephrine;Exhibits;experience;experimental study;falls;Freedom;Fright;Glucagon;Glucose;glucose metabolism;glucose production;glycemic control;Hepatic;Hormonal;Hormones;Human;hyperglucagonemia;Hyperglycemia;Hypoglycemia;Iatrogenesis;improved;Infusion procedures;Ingestion;Insulin;insulin secretion;Insulin-Dependent Diabetes Mellitus;Intravenous infusion procedures;Metabolic;metabolic abnormality assessment;Monitor;Oral;Pancreatic Hormones;Patient Care;Patients;Periodicals;Persons;Play;preservation;primary outcome;protective effect;Protein C;Proteins;Regulation;Research;Research Design;response;Risk;Role;Saline;Scientist;secondary analysis;Somatostatin;subcutaneous;Testing;translational impact;translational potential;Translations;Vascular Diseases;Visit;Work

PROJECT_TITLE: On the regulation of hepatic glucose metabolism during insulin-induced hypoglycemia

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: RELEVANCE (See instructions): Picornaviruses represent an existing and emerging threat to U.S. public health. Achievement of the goals of the application will provide novel targets and mechanisms for development of inhibitors to treat infections by picornaviruses, especially those for which vaccines are not available.

PI_NAMEs: CAMERON, CRAIG E. (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Ablation;Achievement;Anabolism;Appearance;Biochemical;Biological Process;biophysical properties;Categories;Cell Line;Cell Nucleus;Cell Physiology;Cells;Consensus;Cytidine Diphosphate Diglycerides;Cytoplasm;Defect;Development;Ectopic Expression;Educational process of instructing;Enterovirus;Enzymes;experimental study;falls;Family;Family Picornaviridae;Fatty Acids;FOS gene;Genetic Transcription;Genome;Goals;Human poliovirus;Hydantoins;Immunofluorescence Immunologic;Impairment;Infection;inhibitor;insight;Instruction;Laboratories;Life Cycle Stages;Ligase;lipidome;Lipids;Mammalian Cell;Membrane;membrane biogenesis;Monitor;novel;Organelles;paralogous gene;particle;Pathway interactions;Phosphatidylcholine Biosynthesis;Phosphatidylglycerols;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylinositols;Phospholipids;Picornaviridae Infections;posttranscriptional;Protein Isoforms;protein transport;Proteins;Public Health;recruit;Research;RNA;RNA Viruses;trafficking;Translations;Vaccines;Very Long Chain Fatty Acid;Vesicle;Viral Proteins;Virion;Virus;Virus Assembly;Virus Diseases;Virus Replication

PROJECT_TITLE: Picornavirus Genome Replication

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Pediatric;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Prevention;Transplantation;Wound Healing and Care

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative: We propose to study the effects of cutaneous radiation on immunodeficient mice grafted with living, immunologically intact human skin to identify biomarkers that detect radiation exposure and predict radiation induced tissue injury. We will develop point-of-care tests to rapidly screen potentially exposed populations and identify individuals at risk for tissue damage who will require further medical attention.

PI_NAMEs: CLARK, RACHAEL ANN (contact)

PROGRAM_OFFICER_NAME: VEDAMONY, MERRILINE M

PROJECT_TERMS: Adult;Age;Antigen-Presenting Cells;Biological;Biological Markers;biomarker discovery;biomarker identification;biomarker validation;Childhood;cohort;Cutaneous;Detection;DNA Repair;Epithelium;Event;Exposure to;External Beam Radiation Therapy;Gene Expression;Genetic;Goals;Hour;Human;Immune system;Immunocompromised Host;immunodeficiency;Immunodeficient Mouse;Immunologics;Individual;innovation;Intervention;irradiation;Measures;Medical;medical attention;Modality;Modeling;Morphology;mouse model;Mus;Neonatal;neonatal human;Nuclear Accidents;penis foreskin;Phase;Phenotype;point of care testing;Population;Population Heterogeneity;predictive marker;Probability;Proteins;Proxy;Radiation;Radiation Accidents;radiation detector;radiation effect;Radiation exposure;radiation risk;Radiation Tolerance;radiation-induced injury;radiation-induced tissue damage;Rapid screening;Reactive Oxygen Species;Risk;risk prediction;Sampling;Site;Skin;Skin graft;stem cell population;T-Lymphocyte;Testing;tissue injury;Tissues;Validation;vascular bed;Visual

PROJECT_TITLE: Using human skin grafted mice to identify biomarkers of exposure and study effects of radiation on skin


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: PROJECT NARRATIVE This project uses a multimodal, longitudinal approach to uncover the neurobiology of psychosocial stress in human opioid use disorder, with potential to yield novel biomarkers that can be used to identify individuals who are especially vulnerable to stress-related relapse. This will ensure the most efficient allocation of scare clinical resources, as well as provide key empirical support for developing new evidenced-based treatments that target and fortify stress circuitry in opioid use disorder, in service of addressing the opioid public health crisis.

PI_NAMEs: MOELLER, SCOTT J (contact)

PROGRAM_OFFICER_NAME: PARIYADATH, VANI

PROJECT_TERMS: Abstinence;Acute;acute stress;addiction;Addictive Behavior;Address;Adherence;Adrenal Glands;Affect;alpha-amylase;Amygdaloid structure;Area;Aversive Stimulus;Behavioral;Biological;biological adaptation to stress;Biology;brain circuitry;Chronic;Chronic stress;Clinical;Cognitive;cognitive function;combat;craving;Data;Decision Making;design;Development;Diagnosis;Disease;Dose;Drug usage;Emotions;Endocrine;Ensure;Environmental Risk Factor;Evidence based treatment;experience;Exposure to;Food;Fortification;Frequencies;Functional Magnetic Resonance Imaging;Gender;gray matter;Heroin;heroin use;Human;Hydrocortisone;Hypersensitivity;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;Image;Imagery;Impairment;improved;Individual;Individual Differences;insight;Intervention;Interview;Investigation;Knowledge;Laboratories;Longitudinal Studies;Magnetic Resonance Imaging;Matched Group;Measures;Medial;medication-assisted treatment;Methadone;Morphology;morphometry;multimodality;neural;Neurobiology;new therapeutic target;novel;novel marker;Opiate Addiction;Opioid;opioid epidemic;opioid use;opioid use disorder;Outcome;Participant;Patient Noncompliance;Patients;Pattern;Peripheral;Persons;Pharmaceutical Preparations;Phenotype;Pituitary Gland;pre-clinical;Pre-Clinical Model;preclinical study;Prefrontal Cortex;prospective;psychosocial;Psychosocial Stress;Public Health;Reaction Time;Relapse;Research;Resources;response;Salivary;Services;Severities;social;social cognition;Stress;stress reactivity;stressor;Structure;System;Testing;Time;trait;Translating

PROJECT_TITLE: Neural, endocrine, and behavioral markers of psychosocial stress predicting drug use outcomes in human opioid addiction

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Telehealth

ORG_DEPT: MISCELLANEOUS

PHR: PROJECT NARRATIVE To fully leverage the potential of the child care setting for childhood obesity prevention, initiatives must not intervene solely at the child care level, but rather they should also address the health needs of the child care providers. Providers suffer disproportionately high rates of obesity and their own poor eating and physical activity behaviors reduce their confidence and ability to model and promote healthy lifestyle behaviors to children. Go NAPSACC’s weight management program offers a highly implementable, scalable, and sustainable strategy that would improve our understanding of how child care providers own weight and health behaviors impact child care- based obesity prevention initiatives and, if effective, would optimize obesity prevention in the child care setting.

PI_NAMEs: WILLIS, ERIK A (contact)

PROJECT_TERMS: 5 year old;Address;Adopted;arm;Behavior;behavior change;Body mass index;care providers;Caring;Child;Child Care;Cluster randomized trial;Data;Diet;dietary;Dietary intake;early childhood;Eating;Effectiveness;eHealth;Enrollment;Environment;Evaluation;evidence base;Habits;Health;Health and Behavior in Children;Health behavior;Health Personnel;Health Promotion;Healthy Eating;healthy lifestyle;healthy weight;High Prevalence;improved;Instruction;interest;Intervention;Knowledge;meetings;Modeling;nutrition;Obesity;Obesity Epidemic;obesity in children;obesity management;obesity prevention;obesity risk;Organizational Change;Outcome;Outcome Measure;pediatrician;Physical activity;Play;Policies;Prevention program;Process;programs;Provider;provider behavior;Public Health;Randomized;randomized trial;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Research;secondary analysis;Specific qualifier value;Testing;Weight;weight loss intervention;Weight maintenance regimen

PROJECT_TITLE: My weight-their weight: eHealth intervention for managing obesity in child care settings

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-B(02)]


NIH_SPENDING_CATS: Complementary and Integrative Health;Dietary Supplements;Nutrition;Prevention

ORG_DEPT: PEDIATRICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Inflammation is the primary cause of cell death and organ dysfunction in many diseases. Research proposed in this application will open the possibility of using acute intravenous (IV) treatments of emulsion containing medium-chain and omega-3 (n-3) triglycerides enriched in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in targeting rapid n-3 fatty acid membrane enrichment as a new therapeutic approach to ameliorate adverse inflammatory responses. The planned experiments in cells and animal models will establish innovative methods that are adaptable for targeted, rapid delivery of oil-like therapeutic agents to specific cells or tissues, which will be significant to many fields, including immune responses to infection and inflammation-related tissue injury and organ dysfunction.

PI_NAMEs: CHANG, CHUCHUN LIZ (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Acceleration;Acute;acute infection;Address;advanced analytics;Affect;Animal Model;Anti-Inflammatory Agents;Antiinflammatory Effect;Apoptosis;Apoptotic;Area;Bioenergetics;biophysical properties;biophysical techniques;Biophysics;Blood Platelets;Bolus Infusion;Brain Death;Cell Death;Cell membrane;Cell Membrane Structures;Cell model;Cell Separation;Cells;Cellular Structures;Cerebral Ischemia;Chronic;Clinical;Coupled;Data;design;Dimensions;Disease;Docosahexaenoic Acids;Eicosanoids;Eicosapentaenoic Acid;Emulsions;Endothelial Cells;Experimental Animal Model;experimental study;fatty acid oxidation;Fatty Acids;Fish Oils;Fishes;Free Radicals;Functional disorder;healing;Homeostasis;human model;Hydrolysis;Hydrophobicity;Immune;Immune response;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;Injections;innovation;Intake;Intravenous;Intravenous Bolus;Intravenous infusion procedures;intravenous injection;Ischemic Stroke;Laboratories;Leukocytes;lipid disorder;lipid metabolism;lipidomics;Lipids;lipophilicity;Liquid substance;Macrophage;Mass Spectrum Analysis;Mediating;Medium chain triglycerides;Membrane;membrane activity;Membrane Lipids;membrane model;Metabolic;Methods;Modeling;Molecular Conformation;Monoclonal Antibodies;monocyte;Morbidity - disease rate;mouse model;multidisciplinary;Myocardial Infarction;Non-Steroidal Anti-Inflammatory Agents;novel;novel therapeutic intervention;Nuclear Magnetic Resonance;Oils;Omega-3 Fatty Acids;Operative Surgical Procedures;optical imaging;Oral;Organ;organ injury;Parenteral Nutrition;particle;Pathway interactions;Phospholipids;Physical Chemistry;Physiological;Plasma;post stroke;preservation;prevent;Prevention;Production;Property;Regulation;Reporting;Research;Resolution;response;Route;Series;Spinal cord injury;Stimulus;synergism;System;systemic inflammatory response;Therapeutic;Therapeutic Agents;tissue injury;Tissues;TNF gene;Triglyceride Metabolism;Triglycerides;uptake

PROJECT_TITLE: Synergistic Effects of Medium-chain and Omega-3 Triglycerides on Cellular Omega-3 Fatty Acid Enrichment: Characterization, Mechanisms, and Optimization

STUDY_SECTION: INMP

STUDY_SECTION_NAME: Integrative Nutrition and Metabolic Processes Study Section[INMP]


ORG_CITY: AMHERST

ORG_DEPT: PHARMACOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative The Initiative for Maximizing Student Development at the University at Buffalo facilitates successful completion of PhD degrees in biomedical and behavioral sciences. The goal is to provide trainees with research mentoring, career, and professional development to enhance outstanding research, excel in graduate school and successfully enter the biomedical and behavioral scientific workforce. A workforce of talented individuals bringing different perspectives will enhance team science research, discovery of novel therapies and reduce the impact of health disparities.

PI_NAMEs: DUBOCOVICH, MARGARITA L (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Development;Students;Universities

PROJECT_TITLE: Initiative for Maximizing Student Development at University at Buffalo

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Genetic Testing;Genetics;Health Services;Human Genome;Prevention

PHR: Preconception carrier screening is a proven, evidence-based genetic screening approach that has the potential to prevent pregnancies affected by severe recessive genetic conditions, but widespread and equitable implementation of this testing has not been achieved. The proposed research program will evaluate diverse stakeholders’ preferences for how preconception carrier screening could be performed and the personal health implications of carrier screening. This program has the potential to inform implementation efforts to expand access to preconception carrier screening among diverse populations.

PI_NAMEs: HULL, LELAND  (contact)

PROGRAM_OFFICER_NAME: KULCHAK RAHM, ALANNA LEE

PROJECT_TERMS: Address;Adult;advocacy organizations;Advocate;Affect;Age;All of Us Research Program;American;American College of Obstetricians and Gynecologists;Applications Grants;autosome;Award;care coordination;career;carrier testing;Child;Clinical;clinical care;Clinical Trials;Communities;Conceptions;consumer product;cost;Counseling;Cystic Fibrosis;Data;design;Development;Diagnosis;Disease;disease phenotype;effectiveness/implementation study;Embryo;Equity;evidence base;experience;experimental study;Family Planning;Foundations;Future;Gaucher Disease;Genes;Genetic Carriers;Genetic Counseling;Genetic Diseases;Genetic Screening;genetic testing;genetic variant;Genomic medicine;Genomics;Goals;Guidelines;Health;health care delivery;Health Status;Healthcare;Heritability;high risk;implementation barriers;implementation efforts;implementation strategy;Individual;Inequity;informant;Interview;Measurable;Medical Genetics;medical schools;Mentors;Methods;Neighborhood Health Center;Newborn Infant;novel;offspring;Online Systems;Parents;Participant;Pathogenicity;Patient advocacy;Patient Care;patient oriented;Patient Preferences;patient-level barriers;Patients;payment;Perception;phenome;Phenotype;Policies;Policy Making;Population;population based;Population Heterogeneity;preference;Pregnancy;preimplantation;prevent;Preventive;Professional Organizations;programs;prospective;provider-level barriers;randomized, clinical trials;Recessive Genetic Conditions;reproductive;Research;Research Personnel;Research Project Grants;response;Risk;Role;Sampling;screening;screening program;Sickle Cell Anemia;skills;Surveys;System;system-level barriers;Technology;Testing;testing access;Time;tool;Training;Variant;Weight;Women's cohort

PROJECT_TITLE: Elucidating the barriers and facilitators to widespread implementation of preconception genetic carrier screening

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


NIH_SPENDING_CATS: Cardiovascular;Digestive Diseases;Heart Disease;Infectious Diseases;Microbiome;Nutrition;Obesity

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Obesity is a disease that affects more than one-third of the U.S. adult population, resulting in 300,000 deaths per year, and is highly associated with cardiovascular disease and intestinal inflammation. However, our knowledge about the pathways linking obesity to heart and intestinal disease manifestations is incomplete. This application will elucidate how obesogenic high-fat diet mediated intestinal changes increase the risk for atherosclerosis, which will provide critical new insights into the contribution of host-associated microbial communities to health and disease.

PI_NAMEs: BYNDLOSS, MARIANA XAVIER (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Acceleration;Address;Adult;Aerobic;Affect;Amines;Atherosclerosis;atherosclerosis risk;Automobile Driving;Cardiovascular Diseases;cardiovascular disorder risk;Cessation of life;Choline;Chronic;Circulation;Colon;colonic crypt;Complex;Data;Development;Diet;diet-induced obesity;Disease;dysbiosis;Enterobacteriaceae;Epithelial Cells;epithelial repair;Event;experimental study;Exposure to;Goals;gut dysbiosis;gut inflammation;gut microbiota;Health;Heart Diseases;High Fat Diet;host-associated microbial communities;Hyperplasia;In Vitro;in vivo;Inflammatory;innovation;insight;interest;Intestinal Diseases;intestinal epithelium;Intestines;Knowledge;Link;Mediating;Metabolism;microbial;microbiota composition;mitochondrial dysfunction;Modeling;Molecular;monocyte;mouse model;Mucous Membrane;novel;Obesity;obesogenic;Oxides;Pathway interactions;Population;Production;recruit;Research Personnel;Respiration;response;Role;Saturated Fatty Acids;shift work;Study models;Taxon;Testing

PROJECT_TITLE: Obesogenic diet-induced intestinal epithelium repair responses link dysbiosis and cardiovascular disease

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Behavioral and Social Science;Genetics;Human Genome;Mental Health;Prevention;Suicide;Violence Research

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Narrative This project will identify and characterize genetic variants leading to suicide risk in a resource of DNA from >10,000 suicides. Variants are identified from state-of-the-art whole genome sequence data in cases selected for enhanced genetic risk using unique genealogical data and young age at death. Suicides with identified risk variants will be further characterized using demographic data, diagnostic and medication data, autopsy data, familial risk, and polygenic background.

PI_NAMEs: COON, HILARY  (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Age;Autopsy;Back;Behavior;Cause of Death;Cessation of life;Collaborations;Complex;Data;data resource;demographics;Development;Diagnosis;Diagnostic;DNA;effective intervention;Environment;Environmental Exposure;Feeling suicidal;Genes;Genetic;Genetic Enhancement;Genetic Risk;Genetic study;genetic variant;genome sequencing;genome wide association study;genome-wide;Geography;Hand;Health;Heritability;high risk population;Individual;innovation;Intervention;Knowledge;Link;Medical;Medical Examiners;Medical Records;Meta-Analysis;Methods;Molecular;novel;Outcome;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phenotype;phenotypic data;Play;polygenic risk score;Population;population based;Population Database;preventable death;protein protein interaction;Public Health;Recording of previous events;Records;Recurrence;Research;Resources;Risk;Risk Factors;risk perception;risk variant;Role;sample collection;Sample Size;Sampling;Services;Single Nucleotide Polymorphism;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;suicide rate;trait;Utah;Validation;Variant;variant detection;whole genome

PROJECT_TITLE: Genetic risk discovery using WGS from a population-based resource of 10,000 suicide deaths with DNA

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: PROJECT NARRATIVE The proposed research is relevant to the public health because type 2 diabetes and insulin resistance, increasing in prevalence, represents a major burden for both public health and economy. This study will elucidate the role of lysophosphatidylcholine acyltransferase 3 (Lpcat3) in modulating insulin signaling and glucose metabolism, which may unravel potential targets for the intervention of type 2 diabetes.

PI_NAMEs: WANG, BO  (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Acute;Acyltransferase;ADD-1 protein;Affect;Antisense Oligonucleotides;Binding;Binding Proteins;Biochemical;Biological;biophysical properties;blood glucose regulation;Cell membrane;Cells;Data;Development;diet-induced obesity;Endocytosis;Energy Metabolism;enzyme activity;Enzymes;Feedback;FGF21 gene;fibroblast growth factor 21;fluidity;Functional disorder;Glucose;glucose metabolism;glucose production;glucose tolerance;glucose uptake;Goals;Hepatic;High Fat Diet;Homeostasis;Hormones;Hyperglycemia;Hypertriglyceridemia;Impairment;improved;Insulin;Insulin deficiency;Insulin Receptor;insulin regulation;Insulin Resistance;insulin sensitivity;insulin signaling;Insulin Signaling Pathway;Intervention;Knock-out;lipid biosynthesis;lipid metabolism;Lipids;Liver;Lysophosphatidylcholines;Lysophospholipids;Measures;Mediating;Membrane;Membrane Fluidity;Metabolic;Metabolism;microscopic imaging;Molecular;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Nuclear Receptors;Obese Mice;Organ;overexpression;Pathogenesis;Peroxisome Proliferator-Activated Receptors;Phospholipids;Physiology;Play;Polyunsaturated Fatty Acids;Prevalence;Public Health;Regulation;Research;Role;Series;Signal Transduction;Site;Structure of beta Cell of islet;Testing;therapeutic evaluation;Thermogenesis;Triglycerides;Very low density lipoprotein;Work

PROJECT_TITLE: Novel regulation of insulin action in the liver

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative Reference cigar tobacco products are a necessary tool for measuring and reporting harmful and potentially harmful constituents in tobacco products as required under the Family Smoking Prevention and Tobacco Control Act. Three new, machine-made, sheet-wrapped, certified cigar reference products representative of large cigars (processed leaf filler, non-premium), little cigars (brown cigarettes) and small cigars (cigarillos) will be manufactured in one manufacturing run each to ensure product uniformity, and will have certified characteristics to allow for a proficiency testing program, instrument calibration, employee/student training, method validation and for investigational purposes. The University of Kentucky Center for Tobacco Reference Products (CTRP) will expand our program for tobacco analysis and reference tobacco products to support collaborative studies, improved constituent analysis, storage and stability research and the manufacture and distribution of cigar tobacco reference products with significant proposed improvements and development in all of these areas.

PI_NAMEs: CHAMBERS, ORLANDO  (contact)

PROGRAM_OFFICER_NAME: WAKEFIELD, CHRISTI

PROJECT_TITLE: Cigar Reference Products Program


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Since our discovery of Fic domains that mediate AMPylation, other diverse activities performed by bacterial Fic domains have been identified. In metazoans, Fic regulates by reversible AMPylation another protein called BiP(GRP78), which is an essential chaperone found in the endoplasmic reticulum that helps to maintain homeostasis in healthy cells. Our goal is to understand how Fic's activity is regulated, why it has been conserved in mammals and what other chemistries are used by orphan Fic domains.

PI_NAMEs: ORTH, KIM  (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Active Sites;Adenosine Monophosphate;aging related disease;Binding Sites;Biochemistry;Biological;Biological Process;Biology;cancer cell;Cell Physiology;Cells;Chemistry;Drosophila genus;Endoplasmic Reticulum;endoplasmic reticulum stress;Enzymes;Genetic;Goals;Growth;Health;Homeostasis;In Vitro;in vivo;Inflammation;interest;Mammals;Mediating;Modification;Molecular;Molecular Chaperones;Molecular Target;Neurodegenerative Disorders;Neuronal Plasticity;Neurons;Orphan;Play;Proliferating;Proteins;Regulation;response;Role;Sodium Chloride;Stress;Threonine;Transgenic Mice

PROJECT_TITLE: Biochemistry, biology and diversity of Fic domains

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]