ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PI_NAMEs: ALVAREZ-BUYLLA, ARTURO  (contact);HASENSTAUB, ANDREA RAYNE;STRYKER, MICHAEL P

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Adult;Affect;Apoptosis;Brain;brain dysfunction;Bypass;Calcium;Cell Adhesion Molecules;Cell Death;Cells;Cerebral cortex;Code;Cognition;combinatorial;conditional knockout;critical period;Data;Development;Electrophysiology (science);Elements;Esthesia;Excision;Family;Functional disorder;Gene Cluster;Goals;hippocampal pyramidal neuron;Homologous Gene;Image;Impairment;In Vitro;in vivo;Interneurons;Life;Link;Medial;Mediating;Mental disorders;Microelectrodes;migration;Morphology;Mus;mutant;Mutant Strains Mice;Mutation;Neocortex;Nervous System;neural circuit;neuronal survival;Neurons;Pattern;postnatal;postnatal development;Process;Prosencephalon;Protein Isoforms;Pyramidal Cells;Regulation;Resolution;Retina;Role;Signal Transduction;Slice;Spinal Cord;System;Testing;Transfection;Transplantation;two-photon;visual information;visual plasticity

PROJECT_TITLE: Clustered protocadherin regulation of cortical interneuron survival circuit assembly and plasticity


ADMINISTERING_IC: AR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Chronic Pain;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Pain Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: DURHAM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ORTHOPEDICS

ORG_FIPS: US

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Low back pain that continues beyond three months is not well understood. Reasons, why this pain persists, may be due to the body's reaction to this initial painful event. Identifying these reasons that individuals have low back pain could lead to new treatments to prevent chronic LBP.

PI_NAMEs: GOODE, ADAM  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: actigraphy;Acute;Anxiety;B-Lymphocytes;Behavior Therapy;Biochemical;Biochemical Reaction;Biologic Characteristic;Biological;Biological Factors;Biological Markers;biopsychosocial factor;Black Populations;Black race;Blood Cells;Blood specimen;Cell Death;Cell Physiology;Cells;Characteristics;Chronic low back pain;clinical phenotype;Cluster Analysis;Cognitive Therapy;Cohort Studies;Communities;Complex;cost;Counseling;County;cytokine;Data;Dependence;desensitization;Development;Enrollment;Event;Exercise;experience;Funding;Gender;Goals;High Prevalence;Immune;immune activation;Immune response;Immune system;immunoreaction;Immunotherapy;improved;Individual;Inflammation;Inflammatory;Inflammatory Response;Interleukin-1 beta;Interleukin-6;Intervention;intervertebral disk degeneration;Life Style;Ligands;Low Back Pain;Machine Learning;Measurement;Measures;Medical;Mental Depression;Modeling;monocyte;necrotic tissue;new therapeutic target;North Carolina;novel;observational cohort study;Pain;pain chronification;Pain Free;Pain Research;pain score;Pain Threshold;Participant;Patient Self-Report;Patients;Peripheral;Phase;Phenotype;Physical activity;Physical Function;Physical Performance;Plasma;Predictive Factor;pressure;prevent;primary endpoint;Productivity;programs;Proteoglycan;psychologic;psychological distress;psychosocial;Psychosocial Factor;Questionnaires;Race;racial difference;random forest;Reaction;Regulation;Reporting;Research;Resolution;response;risk stratification;Sampling;social;Social Work;sociodemographic factors;sociodemographics;Source;Surveys;systemic inflammatory response;T-Lymphocyte;Testing;TNF gene;United States;unsupervised learning;Validation;Work;years lived with disability

PROJECT_TITLE: Biomarkers to Advance Clinical Phenotypes of Low Back Pain (BACk)

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Machine Learning and Artificial Intelligence

ORG_CITY: Columbus

ORG_DEPT: CHEMISTRY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative  A paradigm of molecular evolution and biophysics is that proteins adopt regular three-dimensional shapes necessary for their cellular functions, yet recent studies of intrinsically disordered proteins support that protein dynamics contribute to both functional plasticity and evolvability over millions of years. The goals of this R35 MIRA are to integrate high throughput mutagenesis screens with biophysical assays and the development of new deep learning models to understand how rapid evolution shapes molecular dynamics and interfaces. These questions will be explored using species-specificity of fertilization as a model.

PI_NAMEs: WILBURN, DAMIEN BEAU (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: 3-Dimensional;abalone;Acceleration;Adopted;Affinity;analytical tool;Animals;Binding;Biochemical;Biological Assay;biophysical analysis;Biophysics;Cell Physiology;Complex;deep learning;deep learning model;Development;Disease;Egg Proteins;empowerment;Evolution;Fertilization;functional plasticity;Genes;Genomics;Germ Cells;Goals;graduate student;Human Genome;Immune;Kinetics;Life;marine;Mass Spectrum Analysis;Mechanics;Methods;Modeling;molecular dynamics;Molecular Evolution;molecular shape;Mutagenesis;Natural Selections;NMR Spectroscopy;Postdoctoral Fellow;Property;Protein Biochemistry;Protein Dynamics;Proteins;Proteomics;Reaction;reproductive;Research;Research Personnel;Shapes;Species Specificity;sperm protein;Structure;System;tool;training opportunity;Trees;undergraduate student;Work

PROJECT_TITLE: Integration of biophysics and deep learning to understand species-specificity of fertilization and the rapid evolution of protein disorder

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Wound Healing and Care

ORG_CITY: BIRMINGHAM

ORG_NAME: SOUTHERN RESEARCH INSTITUTE

ORG_STATE: AL

PHR: The current countermeasures against arsenical-induced toxicity are chelating agents of arsenic and are not effective and highly toxic. We recently reported that Bromodomain 4 (BRD4) inhibitors can significantly improve the severe cutaneous injuries caused by phenylarsine oxide (PAO), an arsenical surrogate that demonstrates similar pathophysiological alterations in the skin and other organs that are caused by other warfare arsenicals. The proposed effort will be focused on the development of orally/topically active hybrid inhibitors of BRD4, RIPK3 and IL6 that lead to the development of a novel and highly effective treatment in reducing arsenical-induced cutaneous inflammation.

PI_NAMEs: ATHAR, MOHAMMAD ;AUGELLI-SZAFRAN, CORINNE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: absorption;Acids;analog;Anti-Inflammatory Agents;Antidotes;Arsenic;Arsenicals;Attenuated;Binding;Biological Assay;Biological Availability;British;Bromodomain;Bulla;candidate identification;Cell Death;Cells;Chelating Agents;Chemical Warfare Agents;Chemicals;cheminformatics;chemokine;Complex;computational chemistry;Computer software;Cutaneous;Cytochrome P450;cytokine;cytotoxicity;Data;design;Development;DMSA;Docking;Drug Design;drug development;Drug Kinetics;effective therapy;efficacy evaluation;Excretory function;Exhibits;experience;Exposure to;Funding Mechanisms;Genes;Goals;Half-Life;high throughput screening;Hybrids;IL-6 inhibitor;IL6 gene;improved;in silico;In Vitro;in vitro testing;in vivo;in vivo evaluation;Inflammation;Inflammatory;Inflammatory Response;Inflammatory Response Pathway;inhibitor;Interleukin-6;Laboratories;Lead;lead candidate;lead optimization;lewisite;machine learning model;Mediating;medical countermeasure;member;Metabolic;Metabolism;Microsomes;Modeling;Molecular Biology;molecular modeling;mouse model;Mus;novel;Oral;Organ;Oxides;Pain;Pathway interactions;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phase;Phosphotransferases;Play;Poison;pre-clinical;preclinical toxicity;Property;propylsulfonic acid;Protein Family;Protein Kinase Interaction;Proteins;Receptor-Interacting Protein;Regulation;Reporting;response;RIPK3 gene;Role;Safety;Series;side effect;Skin;skin damage;Skin injury;small molecule inhibitor;Solubility;Specificity;Structure;Testing;Therapeutic;Therapeutic Index;Tissues;tool;Toxic effect;Vesicants;Work

PROJECT_TITLE: Development of small molecule inhibitors as anti-inflammatory agents and antidotes for arsenicals

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-F(50)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative Pathologically altered affective learning is at the core of nearly every psychiatric disorder. Despite this, little is known about the patterns of neural activity or pathways that are engaged when learning is enhanced or diminished by varying task demands. Using a combination of behavioral tasks, neurophysiology, chemogenetic, and computational modeling approaches this project will establish the specific pathways and mechanisms through which affective learning can be altered.

PI_NAMEs: RUDEBECK, PETER  (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: Affective;Amygdaloid structure;Animal Model;Anxiety Disorders;Area;Attention;Behavior;behavior influence;Behavioral;biomarker identification;Cell Nucleus;Communication;Computer Models;Computing Methodologies;Corpus striatum structure;cortico-limbic circuits;Cues;Data;Environment;experimental study;Feedback;frontal lobe;Genetic;genetic approach;Genetic Models;Goals;Human;human model;Individual;innovation;insight;Investigation;Knowledge;Lead;Learning;Limbic System;Link;Macaca;Measures;Memory;Mental Depression;Mental disorders;Monkeys;Mood Disorders;neural;neural circuit;Neural Network Simulation;Neural Pathways;neural patterning;neuroimaging;neuromechanism;Neurons;neurophysiology;neuroregulation;nonhuman primate;Pathologic;Pathway interactions;Pattern;Perception;Prefrontal Cortex;Probability;Process;psychologic;Punishment;recurrent neural network;response;Rewards;Rodent;Role;Signal Transduction;Stimulus;Testing;Time;Update;Work

PROJECT_TITLE: Neural circuit mechanisms of affective probabilistic learning

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Genetics;Heart Disease;Networking and Information Technology R&D (NITRD);Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: NARRATIVE The ability to reproduce clinical aspects of human heart disease in cellular models using induced pluripotent stem cells (iPSCs) has enormous potential for drug discovery. Realizing this potential, however, has been hampered by the lack of sophisticated tools to read out disease-relevant parameters and relate drug effects to alterations in disease processes. The proposed project will deliver reagents and software to evaluate genes, proteins and drugs for disease-modifying activity in iPSC models in a user-friendly, accessible manner suitable for drug discovery in the biopharmaceutical setting.

PI_NAMEs: MERCOLA, MARK  (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: Acceleration;Adherent Culture;Adoption;Adult;Affect;Assessment tool;Automation;Basic Science;Benchmarking;Biological;Biological Assay;Biological Products;biopharmaceutical industry;Calcium;calcium indicator;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cell Line;Cell model;cell type;Cells;Clinical;Code;computer program;Computer software;computerized tools;Data;Data Analyses;Data Set;Dependence;Development;Diastolic heart failure;Disease;disease model;disease phenotype;drug candidate;drug development;drug discovery;Drug Screening;drug use screening;feature detection;Fluorescence;Generations;Genes;Genetic;Genetic study;genetic variant;graphical user interface;Heart Diseases;Heart failure;heart function;Heterogeneity;Human;human induced pluripotent stem cells;Image;imaging system;Individual;individual patient;induced pluripotent stem cell;insight;instrumentation;Kinetics;Measurement;Measures;mechanical force;meter;Methods;Microscopy;millisecond;Modeling;Modernization;mortality;Myocardial dysfunction;novel therapeutics;patient derived induced pluripotent stem cells;Patients;Performance;Pharmaceutical Preparations;Physiology;Population;Preparation;Procedures;Process;Proteins;Protocols documentation;ratiometric;Readiness;Reagent;Relaxation;Resolution;Rest;Run-On Assays;Scientist;sensor;skills;stable cell line;Standardization;Stem Cell Assay;stem cell model;Systolic heart failure;Technology;Technology Assessment;Time;tool;Traction Force Microscopy;user-friendly;Validation;Viral;Viral Vector;Visualization

PROJECT_TITLE: High throughput platform for simultaneous multiparametric assessment of cardiac physiology for heart failure drug development


NIH_SPENDING_CATS: Genetics

PHR: PROJECT NARRATIVE Transfer RNAs (tRNAs) are the universal adaptor molecules essential for protein synthesis in all living cells and their coordinated and accurate processing is critical to ensure production of a high-quality tRNA pool. Mutations in the human tRNA methyltransferase enzyme Trm10 are associated with a multi-faceted disease phenotype that indicates important functions for Trm10. This project will uncover how diverse Trm10 enzymes modify their specific tRNA substrates and the biological effects of the modification they introduce, to define the role of Trm10 in maintaining optimal cellular health and as a potential novel target for therapies for human disease.

PI_NAMEs: CONN, GRAEME L;JACKMAN, JANE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Address;Adopted;Amino Acid Sequence;analog;Archaea;Aspartic Acid-Specific tRNA;Award;base;Biochemical;biochemical tools;Biological;biological adaptation to stress;Biological Assay;Biological Models;Biological Process;Biology;Cell Physiology;Cells;Chemicals;cofactor;Complex;Cryoelectron Microscopy;Defect;dimer;Disease;disease phenotype;drug sensitivity;Endocrine;Ensure;Enzymatic Biochemistry;Enzymes;Eukaryota;Exhibits;Family;fitness;Functional disorder;Generations;Genetic;genetic approach;Genetic Code;Genetic Models;Health;Homologous Gene;Human;human disease;in vitro Assay;in vivo;Individual;insight;interdisciplinary approach;Investigation;Knowledge;Life;Ligation;loss of function;Maintenance;member;Methylation;Methyltransferase;Modeling;Modification;Molecular;monomer;mutant;Mutation;Neurologic;new therapeutic target;Nucleic Acids;Nucleotides;Organism;Orthologous Gene;Pathway interactions;Pattern;Phenotype;Positioning Attribute;posttranscriptional;Process;Production;Protein Biosynthesis;Proteins;Purine Nucleotides;Quality Control;Ribosomes;RNA;RNA Biochemistry;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;Saccharomyces cerevisiae;Specificity;Structure;Substrate Specificity;Syndrome;System;Time;Tissues;Transfer RNA;Translations;tRNA Methyltransferases;yeast genetics;Yeasts;Zebrafish

PROJECT_TITLE: Mechanisms and biological functions of SPOUT methyltransferases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-V(02)M]


ADMINISTERING_IC: EY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Prevention

ORG_CITY: SALT LAKE CITY

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Age-related changes in the vitreous can cause retinal detachment, which often leads to permanent vision problems that affect quality of life. The goal of this project is to find out why the vitreous changes with age, so that ways to prevent vitreous aging can be developed to prevent retinal detachment in high-risk individuals.

PI_NAMEs: HWANG, EILEEN S (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Address;Advisory Committees;Affect;Age;age related;age related changes;aged;Aging;Animal Model;Area;Award;Biochemistry;Biological;career development;Cell Culture Techniques;Cells;Cold Therapy;Collagen;Collagen Fiber;Collagen Type II;Collagen Type IX;collagenase;Computer Models;Data;Degradation Pathway;density;Deterioration;Digestion;Etiology;Excision;Experimental Models;experimental study;Eye;Eye Movements;Fiber;Future;Gases;Goals;Heterogeneity;high risk population;Human;Image Analysis;Imaging Techniques;Incidence;Incubated;Individual;innovation;International;Intervention;Knock-out;Knowledge;Leadership;Licensing;light scattering;Link;Macrophage;Mechanics;member;Mentors;Methods;Modeling;Molecular;Morbidity - disease rate;Motion;Mus;novel strategies;novel therapeutics;Oryctolagus cuniculus;Pathway interactions;Posterior Vitreous Detachments;prevent;Prevention strategy;Process;Proteins;Quality of life;quantitative imaging;reflectance confocal microscopy;Research;Research Personnel;research study;Retina;Retinal Detachment;Role;skills;Specificity;Structure;Surface;Surgeon;System;targeted treatment;Testing;Therapeutic Studies;Translational Research;United States;Vision;Visualization;Work

PROJECT_TITLE: Cellular, molecular and physical mechanisms of vitreous structural heterogeneity underlying posterior vitreous detachment


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Lung;Neurosciences;Physical Activity

ORG_CITY: TORRANCE

ORG_NAME: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER

PHR: PROJECT NARRATIVE Non-invasive cardiopulmonary exercise testing (CPET) is a quantitative, clinical assessment of the integrated functioning of the neuromuscular, cardiovascular and ventilatory systems under the stress of exercise. It uses combined pulmonary gas exchange, electrocardiography, blood pressure and pulse oximetry to identify functional abnormalities and inform diagnosis and prognosis. This study develops a novel modified CPET protocol and reference values that enriches the clinical utility of CPET by independent assessment of neuromuscular system performance (weakness, fatigue, limitation), at rest and peak exercise, in combination with standard CPET measurements.

PI_NAMEs: ROSSITER, HARRY B (contact)

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: Abdomen;Acute;Aerobic;Affect;age stratification;aged;Biopsy;Blood Pressure;Blood Vessels;Cardiopulmonary;Cardiopulmonary Physiology;Cardiovascular Abnormalities;Cardiovascular Diseases;Cardiovascular Physiology;Cardiovascular system;Caring;Cell Respiration;Chest;Chronic Disease;Chronic Obstructive Pulmonary Disease;Clinical;Clinical assessments;clinical decision-making;clinical practice;clinical prognostic;Data;deconditioning;demographics;Diagnosis;Diagnostic;diagnostic value;Disease;disease prognosis;Disease Progression;Dual-Energy X-Ray Absorptiometry;Dyspnea;Echocardiography;Education;EFRAC;Elderly;Electrocardiogram;Enrollment;Equation;Equipment;Exercise;exercise intolerance;Exercise Test;Exercise Tolerance;exercise training;experience;Fatigue;Functional disorder;Gases;Guidelines;Health system;Heart Diseases;Heart failure;heart preservation;Heart Transplantation;hemodynamics;improved;indexing;Individual;Interruption;Intervention;Isotonic Exercise;laboratory experiment;Leg;Life Expectancy;Lung;male;manufacturing test;Measurement;Measures;men;Monitor;Morphology;Muscle;muscle form;Muscle Weakness;Muscular Atrophy;neuromuscular;Neuromuscular Diseases;neuromuscular function;neuromuscular system;Normal Range;Normalcy;novel;Operative Surgical Procedures;Outcome;Participant;Patients;Performance;Peripheral;Population;Postoperative Period;predictive modeling;preservation;Prognosis;Property;Protocols documentation;Publishing;pulmonary function;Pulmonary Gas Exchange;Pulse Oximetry;Race;reduced muscle mass;Reference Values;Rehabilitation therapy;Reproducibility;response;Rest;risk stratification;Sampling;Sensitivity and Specificity;Severities;sex;Skeletal Muscle;Specificity;Speed;Stratification;Stress;System;Technology;Testing;Therapeutic;Thinness;Training;Training Programs;Translating;Triage;Woman;Work

PROJECT_TITLE: Novel cardiopulmonary exercise testing variables to differentiate neuromuscular deconditioning from disease

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE The Cleveland Alzheimer's Disease Research Center (CADRC) is a collaborative effort amongst Northeast Ohio physicians and scientists from Case Western Reserve University (CWRU), Cleveland Clinic Foundation (CCF), MetroHealth Systems (MHS), University Hospitals (UH), and the Louis Stokes Cleveland VA Medical Center (LSCVAMC) to improve our understanding of why Alzheimer's disease (AD) and Alzheimer's disease- related dementias (ADRD) vary from person to person. The CADRC will create an infrastructure to increase the speed of research efforts of local, national and international investigators and to train the next generation of investigators. Ultimately, the CADRC will contribute to a more individualized treatment approach for individuals suffering with aging-associated brain disorders such as AD and AD-related dementias.

PI_NAMEs: PILLAI, JAGAN AYYAPPAN (contact)

PROGRAM_OFFICER_NAME: SILVERBERG, NINA B

PROJECT_TERMS: Acceleration;Address;African American;aging related;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;amyloid imaging;Autopsy;Behavioral;Biological Markers;Biology;Brain;Brain Diseases;career;career development;cell repository;Cessation of life;Clinic;Clinical;Cognitive;cohort;Collaborations;collaborative environment;Collection;Communities;community center;Consent;Data;data management;data repository;demented;Dementia;Dementia with Lewy Bodies;design;Development;Diagnosis;Disease;Disease Progression;drug discovery;Early identification;education research;Enrollment;Ensure;ethnic minority;Evaluation;Financial Support;Fostering;Foundations;Freezing;Funding;Genetic;Genetic Risk;Goals;health disparity;Heterogeneity;high risk;Human;Image;Impairment;improved;Individual;individualized medicine;Infrastructure;insight;Institution;International;Intervention;Laboratory Finding;Link;Medical center;Memory;mild cognitive impairment;Molecular;Monitor;Motor;National Institute on Aging;neuroimaging;neuropathology;next generation;novel therapeutics;Ohio;outreach;Participant;participant retention;Pathologic;Pathology;patient engagement;Persons;Phenotype;Physicians;Population;precision medicine;Professional Education;programs;protective factors;racial minority;recruit;Research;Research Design;Research Personnel;Resources;Risk;Risk Factors;Scientist;shared repository;social stigma;Speed;Standardization;statistics;success;System;targeted biomarker;therapeutic target;Tissue Sample;Tissues;tool;Training;Translating;Translational Research;translational therapeutics;Translations;Underrepresented Populations;United States Department of Veterans Affairs;United States National Institutes of Health;Universities;University Hospitals;Veterans

PROJECT_TITLE: Cleveland Alzheimers Disease Research Center


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PROJECT_TERMS: Acceleration;Address;Administrator;Advisory Committees;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Biological Markers;Biology;Clinic;Clinical;Collaborations;Communities;COVID-19;Data;data exchange;data management;Dementia;Development;Disease Progression;Early identification;Enrollment;Ensure;ethnic minority;Faculty;Fostering;Foundations;Funding;Goals;Guidelines;Heterogeneity;human subject;Image;Institution;Institutional Review Boards;International;Intervention;Lead;Medical;Medical center;meetings;member;Modification;Molecular;Monitor;Nerve Degeneration;neuroimaging;neuropathology;Ohio;outreach;Pathologic;prevent;Process;Program Research Project Grants;programs;protective factors;Protocols documentation;racial minority;recruit;repository;Research;Research Personnel;Research Support;Risk Factors;Role;Sampling;Site;statistics;Students;success;System;Training;Training Programs;Translating;Translational Research;transmission process;United States Department of Veterans Affairs;United States National Institutes of Health;Universities;University Hospitals;Veterans;Visit;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences

PI_NAMEs: KRAUS, ALLISON L (contact)

PROJECT_TERMS: Address;African American population;Alleles;alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid beta-42;biobank;Biological Assay;biological heterogeneity;Biological Markers;biomarker discovery;Blood;Cataloging;Catalogs;CCL2 gene;Cerebrospinal Fluid;chemokine;Clinic;Clinical;Clinical Data;clinically relevant;Collaborations;Collection;Communities;Consultations;CXCL10 gene;CXCR3 gene;cytokine;Data;data exchange;data management;Data Set;Data Storage and Retrieval;Databases;Dementia;Dementia with Lewy Bodies;Diagnosis;Discrimination;Disease;Disease Progression;distributed data;DNA;education research;Ensure;Foundations;Future;Genetic;genetic analysis;Genetic Diseases;genetic variant;Genotype;Goals;Heterogeneity;Human;Human Resources;Image;improved;Inflammation;Infrastructure;innovation;International;Light;Link;Medical center;Mentors;Mission;Molecular;Molecular Analysis;Molecular Genetics;Monitor;National Institute on Aging;Neurochip;Neurodegenerative Disorders;neurofilament;neuropathology;Other Genetics;Participant;Pathogenicity;Pathology;Plasma;Population;Population Heterogeneity;presenilin-1;Process;programs;protein aggregation;Protein Analysis;protein biomarkers;repository;Research;Research Personnel;Research Project Grants;Saliva;Sampling;Secure;Skin;specific biomarkers;Specimen;success;Symptoms;System;tau Proteins;tau-1;Therapeutic;Time;Training;translational therapeutics;Translations;TREM2 gene;Underrepresented Populations;United States Department of Veterans Affairs;Universities;University Hospitals;Urine

PROJECT_TITLE: Biomarker Core


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Rural Health;Social Determinants of Health

ORG_CITY: RICHMOND

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Public Health Relevance Statement Providing the education community and students with knowledge of the various health professions and multiple ways to reach these professions is a critical need of public health. In addition, an understanding of the various social impacts on health (Social Determinants of Health) and use of data science tools modeled after Precision Health’s use of large data will inform teachers and students of how these tools may inform healthcare. PATHS will use a culturally relevant lens to develop curriculum materials and deliver professional development designed to support teachers and their students and will provide an array of supports for community-engaged projects such as health fairs.

PI_NAMEs: ABRAMS, LISA M;DEMARS, YONELLA ;EDMONDSON, ELIZABETH  (contact);PARKHOUSE, HILLARY E

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Achievement;Address;Ally;Area;Area Health Education Centers;Awareness;career;career awareness;Case Study;Collaborations;Communities;community engagement;Community Health;Community Health Education;Data;Data Science;Dental Hygiene;design;Development;Education;Educational Curriculum;Educational process of instructing;Educational Technology;Enrollment;Environmental Risk Factor;Equipment;Ethnic Origin;Evaluation;Event;experience;Exposure to;Focus Groups;follow-up;formative assessment;Group Interviews;Health;health disparity populations;Health Fairs;health literacy;Health Occupations;Health Sciences;Healthcare;High School Faculty;improved;indexing;Individual;innovation;Instruction;interest;Knowledge;large datasets;Learning;lens;Measures;Medical;meetings;Methods;Modeling;Occupational Therapy;Online Systems;Outcome;Participant;Pathway interactions;peer;Persons;Physical Education;Physical therapy;Precision Health;profession allied to medicine;Program Development;programs;Public Health;public health relevance;Quasi-experiment;Race;Radiation;Research;rural underserved;Schools;Science;Secondary to;simulation;skills;social factors;social health determinants;Social Impacts;STEM career;Students;success;summer institute;Surveys;symposium;teacher;Testing;tool;Training;treatment comparison;treatment group;Virginia;virtual;virtual coach;Work

PROJECT_TITLE: PATHS

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: APPLEBY, BRIAN STEPHEN (contact)

PROJECT_TERMS: Address;Affect;Alleles;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;apolipoprotein E-4;Autopsy;Basic Science;Behavioral;Behavioral Symptoms;Biological Markers;Biology;biomarker development;Blood;Blood specimen;Brain;brain behavior;brain magnetic resonance imaging;Cerebrospinal Fluid;Characteristics;Clinic;Clinical;Clinical Data;clinical heterogeneity;Clinical Sciences;Cognitive;cohort;Collaborations;Collection;Communities;Consent;Data;data management;data sharing;Dementia;Dementia with Lewy Bodies;Development;Disease;Education;education research;Enrollment;ethnic diversity;experience;follow-up;Functional Imaging;Future;Genetic Risk;Goals;Guidelines;Heterogeneity;Human;Image;Individual;inflammatory marker;Infrastructure;insight;International;Language;Lewy Body Dementia;Logistics;Medical;meetings;Mentors;mild cognitive impairment;Minority Recruitment;Mission;Motor;Nerve Degeneration;neuroimaging;neuropathology;Neuropsychology;next generation;nuclear imaging;Older Population;Outcome;outreach;Participant;Pathologic;Pathology;Persons;Phenotype;Population;Population Heterogeneity;Positron-Emission Tomography;precision medicine;Process;recruit;Registries;Research;Research Personnel;Research Support;Resources;Retrieval;Safety;Sampling Studies;Scientist;Sleep;social;socioeconomics;statistics;structural imaging;Target Populations;Therapeutic;Therapeutic Trials;Training;Translating;translational therapeutics;Update;Variant;Visual;Work

PROJECT_TITLE: Clinical Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Osteoporosis;Physical Injury - Accidents and Adverse Effects;Prevention

PHR: Project Narrative Because older adults with Alzheimer's disease and related dementias (ADRD) have a 2-fold increased risk of clinical bone fracture, the project is relevant to public health by measuring the effect of acetylcholinesterase inhibitors on bone metabolism (bone density, bone turnover, and bone quality) among older adults with ADRD. In line with several NIA priorities including multiple comorbidities and care for adults with ADRD, the study will focus on fracture risk factors among older adults with ADRD.

PI_NAMEs: LEE, RICHARD HSANG-YANG (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Acetylcholinesterase Inhibitors;Ache;Address;Adult;aged;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Apoptosis;Area;Biological Markers;bone;Bone Density;bone metabolism;bone quality;Bone Resorption;bone turnover;C-telopeptide;Capsicum;Caring;Cholinergic Receptors;Clinic;Clinical;clinical risk;clinically significant;Cognitive;cohort;comorbidity;design;Diagnosis;donepezil;Dose;Epidemiology;Fracture;fracture risk;Goals;Harm Reduction;hip bone;improved;innovation;Intervention;Knowledge;Measures;Memory Disorders;Morbidity - disease rate;mortality;Muscarinics;N-terminal;Newly Diagnosed;older adult;older men;osteoblast proliferation;Osteoblasts;Osteoclasts;Osteogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacologic Actions;Physical Function;Pilot Projects;Placebos;preclinical study;prevent;Prevention program;Probability;Procollagen;programs;prospective;Public Health;Publishing;Quality of life;Randomized;rational design;recruit;Regimen;Resources;Risk Factors;Roentgen Rays;Side;Trabecular Bone Score;Work

PROJECT_TITLE: Effect of Acetylcholinesterase inhibitors on Bone Metabolism and Fracture Risk Factors among older adults with mild to moderate Alzheimer's Disease

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PI_NAMEs: HAINES, JONATHAN L (contact)

PROJECT_TERMS: Adopted;Agreement;Alzheimer's Disease;Alzheimer's Disease Core Center;Alzheimer's disease related dementia;Area;Biological Markers;Biometry;Clinical;Clinical Data;Collaborations;Collection;Communities;Complication;Computational Biology;Data;data acquisition;Data Analyses;data format;data integration;data management;Data Management Resources;data mining;Data Set;data storage site;Databases;design;electronic data;electronic data sharing;empowerment;Enrollment;Environment;Error Sources;experience;Family;follow-up;Foundations;Funding;Generations;Genetic;Genetic Diseases;Genomics;Goals;human disease;Human Resources;Image;improved;Individual;Informatics;Infrastructure;Institution;Lead;Longitudinal Studies;Machine Learning;Measures;Methods;National Institute on Aging;Neurodegenerative Disorders;Paper;Participant;Policies;Positioning Attribute;Privacy;Procedures;Process;Recording of previous events;Records;Research;Research Design;Research Personnel;research study;Resources;Sampling;Secure;Security;software infrastructure;statistics;success;System;Training;Universities;virtual

PROJECT_TITLE: Data Management and Statistics Core


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Prevention

ORG_CITY: Chapel Hill

ORG_NAME: QATCH TECHNOLOGIES, LLC

PHR: Subcutaneous injections of protein-based therapeutics enable home administration and reduce the load on the healthcare facilities and healthcare costs. However, the injectability of protein-based formulations at the necessary high concentrations for injection cannot be determined at early stages of drug development due to a lack of material and still has high time and material costs at later stages. Our technology addresses this by allowing the measurement of viscosity at shear-rate ranges relevant to injectability and manufacturability using very small volumes of formulations. This technology will enable prescreening and optimizing proteins for injectability during early stages of drug development and reduce the risk of scaling, and the associated costs, of uninjectable proteins. In the long-term, the availability of this technology is expected to increase the number of injectable protein-based therapeutics to address patients needs.

PI_NAMEs: PARLAK, ZEHRA  (contact)

PROGRAM_OFFICER_NAME: BILLINGSLEA, EDDIE

PROJECT_TERMS: Acoustics;Address;Antibody Therapy;Behavior;Biological Assay;Biological Products;Blood capillaries;Chronic;commercialization;Computer software;Consumption;cost;Custom;Data;Development;Devices;Disease Management;Drops;drug development;Drug Formulations;Electronics;Failure;FDA approved;Formulation;Health Care Costs;Health care facility;Home;Industry;Infusion procedures;Injectable;injection/infusion;Injections;instrument;Intravenous infusion procedures;Investments;manufacturability;manufacture;manufacturing process;Marketing;Measurement;Measures;Microfluidics;milliliter;Nature;Patient Preferences;Patients;Persons;Phase;Positioning Attribute;preclinical development;prevent;protein protein interaction;Proteins;prototype;Quartz;research and development;Resolution;Rheology;Risk;Risk Reduction;Sampling;scale up;screening;sensor;Small Business Innovation Research Grant;small molecule;Solubility;Subcutaneous Injections;System;Technology;Temperature;temporal measurement;Testing;Therapeutic;Time;Viral Vector;Viscosity

PROJECT_TITLE: High-throughput injectability screening of high concentration protein formulations by microfluidic quartz resonators


PI_NAMEs: COHEN, MARK  (contact)

PROJECT_TERMS: Address;Affect;age related changes;age related neurodegeneration;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Area;Autopsy;Biological Markers;Blood;Brain;brain tissue;Cerebrospinal Fluid;Classification;Clinical;Cognitive;cohort;Collection;Country;Data;Dementia;Diagnosis;diagnosis standard;Diagnostic;Disease;Education;Enrollment;Ensure;Evaluation;experience;Faculty;Fostering;Freezing;Goals;Histology;Human Resources;Image;Individual;Infrastructure;innovation;International;Investigation;Link;Mentors;Methods;mild cognitive impairment;Molecular;molecular pathology;Nerve Degeneration;Neurodegenerative Disorders;neuropathology;Neurosciences;next generation;Participant;Pathology;Patients;Physicians;Prion Diseases;recruit;Reporting;repository;Research;Research Personnel;Research Project Grants;Sampling;Site;Specimen;Standardization;success;Time;tissue processing;Tissues;Training;Urine;Work

PROJECT_TITLE: Neuropathology Core


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative HIV pre-exposure prophylaxis (PrEP) use and adherence among Black men who have sex with men (MSM) is hampered by structural and psychosocial barriers, resulting in inadequate coverage to reduce HIV infections among this population. We will conduct a randomized control trial (RCT) with a standard of care (SOC) waitlist control to determine the efficacy of C4, an intervention based on self-determination theory, to increase PrEP use and adherence among Black MSM. The findings of this trial will result in an intervention tailored for Black MSM which can be implemented in community setting to increase PrEP use and adherence among Black MSM.

PI_NAMEs: MAGNUS, MANYA ;NELSON, LARON EARNEST;WHITFIELD, DARREN LOVELL (contact)

PROGRAM_OFFICER_NAME: STIRRATT, MICHAEL JAMES

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;AIDS prevention;Area;arm;barrier to care;Biological Assay;black men who have sex with men;Black race;care coordination;care systems;Case Management;Client;Clinic;Clinical;clinical research site;Collaborations;Communities;community setting;cost;Data;Data Collection;District of Columbia;dosage;Dose;efficacy evaluation;efficacy trial;Elements;Enrollment;Epidemic;Evaluation;experience;Exposure to;follow-up;Frequencies;Funding;Gays;Goals;health care disparity;Health care facility;Health Insurance;Health Personnel;health training;Healthcare;HIV;HIV Infections;HIV prevention trials network;implementation science;improved;Incidence;Individual;Inequity;innovation;Institutionalization;Intervention;Interview;Job loss;Laboratories;Learning;Length;Life;men who have sex with men;Methodology;Methods;Modeling;multi-component intervention;New York City;novel;Participant;Pharmaceutical Preparations;Population;pre-exposure prophylaxis;prevention service;Provider;psychosocial;Psychosocial Factor;Public Health;racial disparity;Racial Equity;racism;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;recruit;Regimen;Reporting;Research;Risk;Risk Reduction;Sampling;scale up;Science;Secure;Self Determination;Serum;Service delivery model;service providers;Services;social stigma;Specific qualifier value;staff intervention;standard of care;Statistical Methods;Supportive care;Surveys;Testing;theories;Time;Transportation;trial design;United States;United States National Institutes of Health;Visit;Waiting Lists;Washington;Work

PROJECT_TITLE: A randomized clinical trial of client-centered care coordination to improve pre-exposure prophylaxis use for Black men who have sex with men

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Bioengineering;Dissemination and Implementation Research;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Environmental exposures profoundly shape lifespan health and disease trajectories. The ECHO Measurement Core will advise, orchestrate, and frame the coordinated, sensitive measurement of exposures, developmental processes, and health outcomes central to achieving ECHO's objective of mapping the impact of early exposures on child health and development. We will develop and refine measures for the ECHO Cohort Protocol (ECP), including methods to implement the measures that are culturally sensitive and valid for diverse populations, assist the ECHO Consortium in implementing and evaluating the ECP, and we will lead strategic decision-making and operational strategies to incorporate new and revised measures to advance ECHO Cohort science while minimizing participant and staff burden.

PI_NAMEs: CELLA, DAVID  (contact);GERSHON, RICHARD

PROGRAM_OFFICER_NAME: MASH, CLAY

PROJECT_TERMS: Adoption;Adult;Brain;Child Development;Child Health;Clinical Research;cohort;Cohort Studies;Collaborations;Collection;Communication;Computers;Conceptions;Data;Data Analyses;Data Collection;Data Element;data harmonization;Decision Making;Dedications;Detection;Development;Developmental Process;Disease;Ensure;Environmental Exposure;Environmental Risk Factor;flexibility;Foundations;Goals;Health;implementation fidelity;implementation strategy;improved;innovation;instrument;Investigation;Lead;life span;Link;Manuals;Maps;Measurement;Measures;Methods;mindfulness;Monitor;neurodevelopment;novel;Obesity;Outcome;Participant;participant retention;Perinatal Exposure;Personal Satisfaction;Persons;Population Heterogeneity;postnatal;preclinical study;Predisposition;Procedures;Process;Protocols documentation;Psychometrics;Public Health;Publications;remote assessment;Reproducibility;Resources;Respondent;Risk;Science;Scientist;Shapes;Site;sound;Specific qualifier value;Standardization;standardize measure;Structure;Support System;System;Technology;Testing;Time;Training;Visit;wearable sensor technology;Work

PROJECT_TITLE: The ECHO Measurement Core: A Framework and Resource for Assessing Environmental Exposure and Child Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-G(51)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: SAJATOVIC, MARTHA X (contact)

PROJECT_TERMS: Acceleration;African American;African American population;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;American;apolipoprotein E-4;Awareness;Biological;Caregivers;Caring;Cities;Clinical;clinical center;Clinical Investigator;Clinical Research;Clinical Trials;Cognitive;Collaborations;Communication;Communities;community academic partnership;community collaboration;community engagement;Community Health Education;Community Outreach;Country;County;COVID-19 pandemic;Data;Dementia;Dementia with Lewy Bodies;Diagnosis;Disease;Elderly;Enrollment;Ensure;ethnic minority;ethnoracial minority;Evaluation;experience;Feedback;Foundations;Funding;Goals;Heterogeneity;high risk;Hispanic;Hispanic Populations;Home;human old age (65+);Impaired cognition;improved;Individual;Industrialization;innovation;interest;Investigation;Leadership;marginalized population;member;Methods;metropolitan;mild cognitive impairment;Minority;Mission;Modeling;Nature;Neurocognitive Deficit;Newsletter;Ohio;outreach;Outreach Research;Participant;participant retention;Pathologic;Patient Recruitments;personalized care;Persons;Population;Productivity;programs;progression risk;Protocols documentation;psychologic;racial minority;recruit;Research;Research Personnel;Risk;Rural Community;Sampling;social culture;Special Population;Subgroup;suburban communities;Underrepresented Populations;Veterans;virtual;volunteer;web site;webinar;Work

PROJECT_TITLE: Outreach, Recruitment and Engagement Core


ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Proper segregation of chromosomes during mitosis is essential for genome integrity and cellular viability. Despite chromosome segregation being a fundamental biological process, the DNA and proteins that make up the segregation machinery (i.e. the centromere) rapidly evolve. This proposal studies the functional consequences of rapid centromere evolution on genome integrity during early embryogenesis and how they might contribute to infertility and aneuploidy.

PI_NAMEs: LAMELZA, PIERO  (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Affinity;Aneuploidy;Binding;Biochemical;Bioinformatics;Biological;Biological Assay;Biological Process;career;Cell Line;Cells;Centromere;centromere protein A;centromere protein C;Chromatin Modeling;chromatin remodeling;chromosome missegregation;Chromosome Segregation;Chromosomes;Conflict (Psychology);Cytoplasm;Data;Dicentric chromosome;DNA;DNA Binding;DNA Binding Domain;DNA Sequence;egg;Embryo;Embryonic Development;Eukaryota;Evolution;Exhibits;Female;Fertilization;Genetic;Genome;genome integrity;Goals;Histone H3;hybrid protein;Hybrids;In Vitro;Infertility;Injections;Measures;Meiosis;Mitosis;Molecular Profiling;Mus;mutant;novel;Nucleosomes;Organism;Orthologous Gene;paralogous gene;Positioning Attribute;preference;Process;programs;protein function;Proteins;reconstitution;recruit;reproductive;Role;Satellite DNA;Scaffolding Protein;segregation;Selfish DNA;Selfish Genes;sperm cell;Stretching;System;Techniques;Testing;tool;Training;Untranslated RNA;Variant;zygote

PROJECT_TITLE: Testing the functional consequences of rapid centromeric DNA and protein evolution


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: HALETHORPE

ORG_NAME: GLYCOMANTRA, INC.

PHR: Project Narrative Galectin-3 promotes insulin resistance of type 2 diabetes by interacting with the insulin receptor. GlycoMantra’s commercial goal is to develop a high-affinity galectin-3 antagonist to restore insulin sensitivity. During this funding period, we will complete the critical path preclinical studies required for our IND submission to the FDA to enable the initiation of a first–in–human Phase 1 clinical trial.

PI_NAMEs: AHMED, HAFIZ  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Affinity;Agreement;Animal Experiments;Animal Model;Animals;antagonist;Apoptosis;Area;B-Lymphocytes;Binding;Biological;Biological Markers;Biological Products;Biological Response Modifier Therapy;Blood;Capital;Carbohydrates;cell bank;Cells;Chinese Hamster Ovary Cell;clinical development;Clinical Trials;Critical Pathways;Cyclic GMP;design;Diabetes Mellitus;diet-induced obesity;dietary;Dose;drug candidate;drug development;Engineering;experimental study;Extracellular Matrix;fasting glucose;Fatty acid glycerol esters;FDA approved;first-in-human;Frequencies;Funding;Future;Galectin 3;Genes;glucose tolerance;Goals;High Fat Diet;Home;Human;Immune;impaired glucose tolerance;improved;Industry;Inflammation;Inflammatory;insight;Insulin;Insulin Receptor;Insulin Resistance;insulin sensitivity;insulin signaling;islet;Knowledge;Lectin;Licensing;Ligands;Liver;Macrophage;manufacture;manufacturing process;Measures;Mediating;Modeling;Molecular;Muscle;nanomolar;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Organ;Outcome;Outcome Study;Patients;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pharmacologic Substance;Phase;phase 1 study;Phase I Clinical Trials;Positioning Attribute;preclinical study;primary endpoint;Process;product development;Production;Proteins;Receptor Signaling;Regulation;Research;Resolution;restoration;Running;scale up;Source;subcutaneous;Subcutaneous Injections;Suspensions;technological innovation;Technology;Therapeutic;Time;Toxicology;Training;Transfection;Translating;Work

PROJECT_TITLE: Targeting galectin-3 to overcome insulin resistance in type 2 diabetes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-K(10)B]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: LOWE, MARK J (contact)

PROJECT_TERMS: Address;Alzheimer's Disease;Alzheimer's Disease Core Center;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Amyloid;biomarker development;Blood - brain barrier anatomy;Brain;career;Cerebrovascular Circulation;Clinic;Clinical;Clinical Trials;Collaborations;Communities;contrast enhanced;Data;data acquisition;Data Analyses;data curation;data dissemination;data exchange;data management;Data Storage and Retrieval;Dementia;Diagnostic Imaging;Discipline of Nuclear Medicine;Disease Progression;education research;education resources;Environment;Evolution;experience;Fingerprint;Functional disorder;Generations;Goals;Histopathology;Human Resources;Image;Image Enhancement;image reconstruction;Imaging Techniques;Individual;Infrastructure;interest;Investigation;Laboratory Research;Magnetic Resonance Imaging;Measures;Mentors;Methods;Monitor;multimodality;neuroimaging;neuropathology;Ohio;outreach;Participant;patient population;Population;Positron-Emission Tomography;prospective;protocol development;quality assurance;recruit;Research;Research Personnel;Resolution;Resources;Risk;Software Tools;Specific qualifier value;statistics;Structure;Techniques;Tissues;tool;Training;Training and Education;treatment response;ultra high resolution;Universities;vascular injury

PROJECT_TITLE: Neuroimaging Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences;Precision Medicine

ORG_CITY: South San Francisco

ORG_NAME: SUPERFLUID DX, INC.

PHR: We will optimize and establish clinical-grade protocols to minimize potential assay variabilities for cell free messenger RNA sequencing (cf-mRNA-Seq). Subsequently, we will profile the cf-mRNA transcriptome of well-characterized Alzheimer’s disease (AD), mild cognitive impaired (MCI) subject samples and build and validate diagnostic and prognostic classifiers for AD. If successful, our assay may transform non-invasive diagnosis and prognosis of AD and has a potential of developing a robust and cost-effective clinical assay.

PI_NAMEs: TODEN, SHUSUKE  (contact)

PROGRAM_OFFICER_NAME: RADOJA, NADEZDA

PROJECT_TERMS: abeta deposition;Affect;Age;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease diagnostic;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease test;Alzheimer’s disease biomarker;Amyloid beta-Protein;Autopsy;Bioinformatics;Biological Assay;Biological Markers;biomarker development;Blood;Blood specimen;Brain;brain dysfunction;brain tissue;Cells;Cerebrospinal Fluid;Cerebrospinal Fluid Proteins;Characteristics;Circulation;Clinical;cohort;comparative efficacy;cost;cost effective;Dementia;Development;Diagnosis;Diagnostic;diagnostic biomarker;Diagnostic tests;Disease;disease prognosis;Evaluation;Gene Expression Profile;Genes;Human;Image;imaging modality;Impaired cognition;Individual;Inflammation;Lead;liquid biopsy;Liver diseases;Machine Learning;Malignant neoplasm of liver;Malignant Neoplasms;Measures;Messenger RNA;mild cognitive impairment;misfolded protein;mitochondrial dysfunction;Molecular;Monitor;Nervous System Disorder;Neurodegenerative Disorders;Neurofibrillary Tangles;neuron loss;next generation sequencing;noninvasive diagnosis;Nucleic Acids;Outcome;oxidation;Pathologic;patient stratification;Performance;Persons;Plasma;Plasma Cells;Positron-Emission Tomography;predictive marker;Procedures;profiles in patients;Prognosis;prognostic;protein biomarkers;Protocols documentation;Research Personnel;Resources;Sampling;Severities;Signal Transduction;Solid;Source;Specimen;Symptoms;Synapses;Talents;tau Proteins;Testing;Thinness;Tissue Sample;Transcript;transcriptome;transcriptome sequencing;Validation

PROJECT_TITLE: Development of cell free messenger RNA-based non-invasive diagnostic biomarker for Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-G(13)B]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Hematology;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Narrative Internal tandem duplication within FLT3 (FLT3-ITD) is frequently mutated in acute myeloid leukemia (AML) and correlates with poor prognosis. Mechanisms underlying the aberrant FLT3-ITD subcellular localization and signaling remain poorly understood. We discovered that FLT3-ITD is palmitoylated, disruption of which relocalizes FLT3-ITD and rewires FLT-ITD signaling, thus we propose to define the physiological and clinical significance of FLT3-ITD palmitoylation in AML and identify novel therapeutics to target FLT3-ITD+ AML.

PI_NAMEs: TONG, WEI  (contact)

PROGRAM_OFFICER_NAME: SAYYED, ZULEKHA I

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Acyltransferase;Binding;Biology;Breeding;cell growth;Cell Line;Cell membrane;Chemicals;clinically relevant;clinically significant;Collaborations;combinatorial;Cysteine;Disease;DNMT3a;Endoplasmic Reticulum;Enzymes;Equilibrium;FLT3 gene;Genetic;genetic approach;Goals;Grant;Growth;Hematopoiesis;Hematopoietic stem cells;Human;Impairment;in vivo;in vivo Model;inhibitor;innovation;insight;Knock-in Mouse;leukemia;Leukemic Cell;leukemogenesis;Ligands;Lipids;Malignant - descriptor;MAP Kinase Gene;Mediating;Minor;Minority;Modeling;Modification;Molecular;Molecular Biology;mouse model;Mus;mutant;Mutate;Mutation;Myeloproliferative disease;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;Outcome;palmitoylation;Pathway interactions;Patients;pharmacologic;Pharmacology Study;Phosphorylation;Physiological;PI3K/AKT;PIK3CG gene;Post-Translational Protein Processing;Prognosis;Proliferating;Protein Tyrosine Kinase;Proteins;Proteomics;Proto-Oncogene Proteins c-akt;Receptor Protein-Tyrosine Kinases;Regulation;Relapse;response;Role;Signal Pathway;Signal Transduction;Signaling Protein;Spatial Distribution;Stat5 protein;Surface;synergism;targeted treatment;Therapeutic;Tyrosine Kinase Inhibitor;Ubiquitination;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Regulation of FLT3 Signaling in Leukemia

STUDY_SECTION: BCO

STUDY_SECTION_NAME: Biochemical and Cellular Oncogenesis Study Section[BCO]


ORG_CITY: PASADENA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative:  Biocatalysis is revolutionizing the pharmaceutical and chemical industries, with recent advances in enzyme engineering enabling the synthesis of complex molecules with high efficiency and selectivity. However, the chemical transformations enzymes catalyze are restricted compared to their chemical equivalents, limiting their application. Herein are described two proposals to engineer two distinct enzyme classes, heme enzymes and methionine sulfoxide reductase, to expand their capabilities outside their natural function to synthesize chiral α- CF3 amines, sulfoxides, and sulfoximines, functional groups with great medicinal value.

PI_NAMEs: ALFONZO, EDWIN  (contact)

PROJECT_TERMS: Adoption;Amination;Amines;Biochemical;Biological Availability;Biology;Brain;catalyst;Chemical Industry;chemical reaction;Chemicals;Chemistry;clinical candidate;Clinical Medicine;Complex;cost;Dimethyl Sulfoxide;Directed Molecular Evolution;drug discovery;Drug Industry;Electrons;Engineering;enzyme activity;enzyme mechanism;Enzymes;Exclusion;Exhibits;experience;functional group;Grant;Health;Heme;Hemeproteins;Human;improved;innovation;Knowledge;Laboratories;Ligands;Medicine;Mentors;Metals;methionine sulfoxide reductase;Methods;Molecular;Molecular Structure;nitrene;Nitrogen;Organic solvent product;Organism;Outcome;Oxidants;Oxidases;oxidation;Penetrance;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pharmacologic Substance;Phase;Prevalence;Price;Process;Property;prospective;Reaction;reaction rate;Side;Source;success;Sulfoxide;Sulfur;Technology;therapeutic candidate;thioether;Time;Toxic effect;Transferase

PROJECT_TITLE: Unlocking New Chemistries in Extant Enzymes for Synthesizing Bioactive Molecules


PI_NAMEs: ZHU, XIONGWEI  (contact)

PROJECT_TERMS: Acceleration;Address;Age;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;Articulation;Basic Science;career;career development;Clinical;clinical care;clinical center;Clinical Research;Clinical Sciences;Collaborations;collaborative environment;Communities;Competence;cost of dementia;Dementia;design;Development;Diagnosis;Direct Costs;Disease;Education;education research;education resources;Educational Activities;Educational process of instructing;experience;Extramural Activities;Faculty;faculty mentor;Family;Fostering;Funding;Future Generations;Goals;Grant;Growth;Health Care Costs;Health Services;healthy aging;Human Resources;Incidence;Infrastructure;innovation;Institution;interdisciplinary collaboration;International;Intervention;Knowledge;Laboratory Research;Mentors;Mentorship;Nature;Nerve Degeneration;neurobehavioral;novel;Participant;Patients;Population;Postdoctoral Fellow;programs;Research;research and development;Research Personnel;Research Project Grants;Research Project Summaries;Research Support;Research Training;Resource Sharing;Resources;Science;Scientist;Services;Societies;Specialist;success;Talents;Training;Training and Education;Training and Infrastructure;Training Programs;Training Support;Translating;Translational Research;translational research program;Work

PROJECT_TITLE: Research Education Component


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Disability Research;Health Services;Physical Rehabilitation;Rehabilitation

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Nearly 2 million older persons are admitted to an intensive care unit (ICU) every year; of those who survive, half will not achieve functional recovery, with profound consequences for patients, caregivers, and society. The proposed research is relevant to public health because it will ascertain the unmet needs of older adults who return home (either directly or after short-term rehab) after an ICU hospitalization, evaluate the association of these unmet needs with clinically relevant outcomes, and assess barriers and facilitators to addressing these unmet needs. The proposed research will inform the development and evaluation of a subsequent intervention to improve functional outcomes among older ICU survivors, in alignment with the NIH’s mission to reduce disability.

PI_NAMEs: FERRANTE, LAUREN  (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Activities of Daily Living;Address;Admission activity;Affect;Age;American;Caregivers;Caring;Clinical;clinically relevant;cohort;Communities;Critical Illness;Data;Dependence;Destinations;Development;disability;disability burden;Elderly;Enrollment;Evaluation;evidence base;Evidence based intervention;Foundations;frailty;Frequencies;functional improvement;functional outcomes;Future;Geriatrics;Goals;health management;Health system;Hearing;Home;Home Care Services;Home environment;hospital readmission;Hospitalization;Hospitals;human old age (65+);Impairment;improved;innovation;Intensive Care Units;Intervention;Interview;Left;lens;Logistics;Mission;Modification;mortality;Nursing Homes;older adult;Older Population;Outcome;Participant;Patients;Persons;Population;Public Health;Recovery;Recovery of Function;rehabilitation service;Rehabilitation therapy;Research;Sensory;Sensory impairment;Services;Severities;skills;Societies;Structure;Survivors;Testing;therapy development;United States National Institutes of Health;Vision;Work

PROJECT_TITLE: Evaluating the Unmet Needs of Older Adults to Promote Functional Recovery after a Critical Illness (LANTERN)

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Neurosciences;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Cannabis use is common among adolescents and linked to psychiatric risks. Understanding the neural processes that predict and result from adolescent cannabis use may lead to improved interventions for cannabis use and cannabis use disorder prevention and treatment. Through this award, I will gain training in complementary big data methods and precision neuroimaging within patient intervention designs to optimize neural markers of adolescent cannabis use and provide actionable information towards future clinical translation.

PI_NAMEs: TERVO-CLEMMENS, BRENDEN CRAIG (contact)

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: 14 year old;16 year old;18 year old;Abstinence;addiction;Address;Adolescence;Adolescent;Adult;Age;Award;Big Data;Big Data Methods;Biochemical;Biometry;Brain;Cannabis;career development;Clinical;clinical training;clinical translation;Clinical Trials Design;clinically relevant;Cognitive;cognitive development;contingency management;Corpus striatum structure;Data;data integration;Data Set;design;Development;disorder prevention;Enrollment;Epidemiologic Methods;Epidemiology;expectation;Family history of;Frequencies;Functional Magnetic Resonance Imaging;Funding;Future;Goals;Image;improved;Impulsivity;Incentives;Income;innovation;Intervention;large scale data;Link;Machine Learning;magnetic resonance imaging biomarker;marijuana use;marijuana use disorder;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Meta-Analysis;Methodology;Methods;Monitor;multidisciplinary;Multivariate Analysis;neural;neurodevelopment;neuroimaging;Neurosciences;Outcome;patient oriented;Patients;Pharmacological Treatment;Phenotype;Population;Population Study;pre-clinical;predictive modeling;prevent;Probability;Process;programs;prolonged abstinence;Protocols documentation;Psychiatry;psychosocial;Psychotic Disorders;Randomized;Recovery;Reproducibility;Research;research and development;Research Methodology;response;Rest;reward circuitry;Rewards;Risk;Risk Factors;Role;Sampling;Scanning;skills;social determinants;Specificity;Substance Use Disorder;support vector machine;Testing;therapy design;Time;Training;trait;Translational Research;Translations;Validation

PROJECT_TITLE: Leveraging complementary big data methods and patient intervention designs to optimize neural markers of adolescent cannabis use

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Chronic Liver Disease and Cirrhosis;Clinical Research;Dementia;Digestive Diseases;Liver Disease;Mental Health;Neurodegenerative;Neurosciences;Organ Transplantation;Transplantation

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The spectrum of post-liver transplant (LT) cognitive impairment—from subtle attentional changes to Alzheimer’s Disease and Related Dementias (ADRD)—is not well characterized and as a result, clinicians do not screen for cognitive impairment in the post-LT setting, LT patients are not referred to specialists for timely diagnosis of their cognitive impairment, and strategies that might reduce cognitive decline are not implemented. This project will address an enormous unmet need for deep characterization of the spectrum of cognitive impairment in the LT population that has a high burden of conventional ADRD risk factors but has traditionally been excluded from ADRD studies. Furthermore, we will establish new neuro-hepatology collaborations and develop a unique cohort of LT recipients with rich cognitive data that may yield novel insights into liver- and transplant-specific contributors to ADRD in all populations.

PI_NAMEs: LAI, JENNIFER C. (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Acute;Address;Age;Alcohol consumption;Alzheimer's disease related dementia;Attention;Biological Markers;Blood Pressure;Brain imaging;brain magnetic resonance imaging;Caregivers;Caring;Cessation of life;Chronic;Cirrhosis;Cognition Disorders;Cognitive;cognitive function;cognitive testing;cohort;Collaborations;comorbidity;Cox Models;Data;Delirium;Dementia;dementia risk;Diabetes Mellitus;Diagnosis;Disease;Dose;Enrollment;Etiology;Exclusion;experience;Foundations;frailty;Funding;General Population;Goals;Guidelines;Health;Heavy Drinking;Hepatic Encephalopathy;Hepatology;Hyperammonemia;Hypertension;Immunosuppression;Impaired cognition;improved;Incidence;Infrastructure;insight;Interview;Knowledge;Lewy Bodies;Link;Liver;Liver diseases;liver transplantation;Metabolic syndrome;mixed dementia;Nested Case-Control Study;Neurobehavioral Manifestations;Neurocognitive;Neurologic;neuropsychiatry;novel;Organ Transplantation;Outcome;Participant;Pathway interactions;Patient Care;Patient Outcomes Assessments;Patients;Personal Satisfaction;Pilot Projects;Plasma;Population;postoperative delirium;Practice Guidelines;premature;Prevalence;prospective;Protocols documentation;Recommendation;Research;Research Design;Research Personnel;Risk Factors;Role;screening;sex;Site;Solid;Specialist;Stress;Structure;survival prediction;Testing;Time;tool;Transplant Recipients;Transplantation;United States National Institutes of Health;Vascular Dementia;Visit

PROJECT_TITLE: The spectrum of cognitive impairment including Alzheimer’s Disease and Related Dementias after liver transplantation

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Atherosclerosis;Behavioral and Social Science;Cardiovascular;Childhood Obesity;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Household Energy Combustion;Health Effects of Indoor Air Pollution;Heart Disease;Hypertension;Kidney Disease;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: LEXINGTON

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Household air pollution (HAP) describes the health and environmental impacts of pollutants produced from incomplete combustion of solid fuels such as wood, coal, and charcoal that are burnt on open fires or wood- burning stoves in poorly ventilated homes and releases suspended particulate matter (PM). Exposure to household air pollution is thought to be related to worse cardiovascular and kidney health beginning in childhood and this study will examine how household air pollution increases risk for hypertension in obese children and adolescents. Understanding and identifying these children and adolescents at greatest risk for disease due to household air pollution will develop new treatments to improve their health.

PI_NAMEs: MURPHY, MARGARET O. (contact)

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: 18 year old;Address;Adipocytes;adipokines;adiponectin;Adolescent;Adolescent obesity;Adult;Adverse effects;age group;aged;Air;ambient air pollution;Animals;Appearance;Biological Markers;Biometry;Blood Pressure;blood pressure regulation;burden of illness;Cardiorenal syndrome;Cardiovascular Abnormalities;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;career;career development;Charcoal;Child;Childhood;Chronic;Chronic Kidney Failure;circadian;Cities;Classification;Clinic;Clinical Research;Coal;coarse particles;cohort;Coronary Arteriosclerosis;Devices;Diabetes Mellitus;Diagnosis;Diameter;Disease;disorder risk;Diurnal Rhythm;Early Intervention;Environment;Environmental Exposure;Environmental Impact;Exposure to;Filtration;fine particles;Fire - disasters;Goals;Health;Health Care Costs;high body mass index;high risk;high risk population;High School Student;Home;Household;Household Air Pollution;Human;Hyperlipidemia;Hyperplasia;Hypertension;Hypertrophy;IL6 gene;improved;Inflammation;Inflammatory;insight;instrumentation;intercellular cell adhesion molecule;Intervention;Investigation;Kentucky;Kidney;Left Ventricular Hypertrophy;Link;Literature;low socioeconomic status;Measurement;Measures;Medical;Mentors;meter;Morbidity - disease rate;mortality;Nephrology;Obesity;obesity in children;Participant;Particulate Matter;Patient Recruitments;Patients;Pediatric Hospitals;Pilot Projects;pollutant;Population;Prevalence;Prevention strategy;Public Health;Publishing;Random Allocation;rational design;recruit;Research;Risk;Risk Factors;risk stratification;Role;Rural Population;Severities;solid fuel;statistics;Surveys;synergism;systemic inflammatory response;Testing;TNF gene;Training Programs;Translational Research;ultrafine particle;United States;Variant;ventilation;wasting;Wood material;Wood stove;Youth

PROJECT_TITLE: Household Air Pollution, Adiposity, and Cardiorenal Disease Risk in Children


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Networking and Information Technology R&D (NITRD);Telehealth

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Up to 42% of patients with gastroesophageal reflux disease (GERD) experience uncontrolled, chronic symptoms and nearly 50% demonstrate low patient activation scores. This proposal aims to improve health outcomes for patients with GERD, by harnessing patient activation and motivating behavioral change as a framework for a mobile health (mHealth) Question Prompt List (QPL) intervention. Results will develop a usable mHealth application and collect preliminary data on health outcomes to inform a future R01-funded clinical trial.

PI_NAMEs: KAMAL, AFRIN  (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Acids;Address;Adherence;American;Barrett Esophagus;behavior change;Behavioral;career development;Clinical;clinical care;Clinical Trials;Communication;Communities;community setting;cost;Data;design;Development;Disease;Dose;effective intervention;efficacy testing;Empathy;Esophageal Adenocarcinoma;Esophageal Diseases;Esophagus;experience;Face;Feedback;Focus Groups;Foundations;Funding;Future;Gastroenterology;Gastroesophageal reflux disease;Goals;Health;health care service utilization;health related quality of life;Health Status;Healthcare;ideation;implementation science;improved;Individual;Infrastructure;innovation;insight;Intervention;K-Series Research Career Programs;Knowledge;Manuscripts;Measures;Medical;medication compliance;Mentorship;Methodology;Methods;mHealth;mhealth interventions;mobile application;Mobile Health Application;Modeling;motivated behavior;Outcome;Paper;Patient-Focused Outcomes;Patients;persistent symptom;Physicians;Pilot Projects;pilot test;Population Heterogeneity;primary outcome;Process;Protocols documentation;prototype;Qualitative Methods;Quality of life;Randomized;reduce symptoms;Research;Resources;Risk;Role;Sampling;secondary outcome;Severities;Shapes;skills;Socioeconomic Status;standard of care;success;Symptoms;System;Testing;Thinking;Time;Translating;Update;usability;user centered design;Visit;Work

PROJECT_TITLE: Developing, Refining, and Testing a Mobile Health Question Prompt List in Gastroesophageal Reflux Disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Nutrition;Orphan Drug;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: Narrative More than 200,000 patients every year are affected by malignant brain tumors and these tumors show very high proliferation with increased energy demand for their growth. The goal of this proposal is to identify the key energy sources for brain tumor growth in patients through a translational molecular imaging approach that uses non-radioactive 13C-enriched nutrients and NMR Spectroscopy. Expected outcome of this study will generate key information to develop new targeted therapy.

PI_NAMEs: PICHUMANI, KUMAR  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Acetates;Acetyl Coenzyme A;Acetylcarnitine;Adjuvant Therapy;Affect;aggressive therapy;beta-Hydroxybutyrate;Bioenergetics;Biological;Brain;Brain Neoplasms;cancer cell;Cancer Patient;Carbon;Carbon Isotopes;Cell Line;Cell membrane;Citric Acid Cycle;clinical development;Clinical Protocols;Clinical Trials;clinically relevant;Complex;Data;Death Rate;design;Development;Diagnostic;drug development;drug testing;Energy Metabolism;Energy-Generating Resources;Enrollment;Environment;Erythrocytes;Excision;first-in-human;Generations;Glioblastoma;Glioma;Glucose;Goals;Growth;Histologic;Hospitals;Human;imaging approach;improved;in vivo;in-vivo diagnostics;inhibitor;Institutional Review Boards;Intervention;Intravenous infusion procedures;Isocitrate Dehydrogenase;ketogenic diet;Ketone Bodies;Knowledge;Label;Link;lipid biosynthesis;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Malignant neoplasm of brain;Malignant Neoplasms;Mass Spectrum Analysis;Metabolic;Metabolic Pathway;Metabolism;Metastatic malignant neoplasm to brain;Methodist Church;Methods;Mitochondria;molecular imaging;Mutate;neoplastic cell;new therapeutic target;NMR Spectroscopy;Normal Cell;novel;novel marker;novel therapeutic intervention;novel therapeutics;Nuclear Magnetic Resonance;Nutrient;nutrient metabolism;Operative Surgical Procedures;Oral cavity;Outcome;Outcome Study;overexpression;oxidation;Patient Care;Patients;Phase I Clinical Trials;Physiological;Pilot Projects;Play;pre-clinical;Preclinical Testing;Prediction of Response to Therapy;Primary Brain Neoplasms;Production;Proliferating;Property;Radioactivity;Resected;Slice;small molecule;small molecule inhibitor;Solid Neoplasm;Source;spectroscopic imaging;Starvation;targeted treatment;Technology;Testing;Therapeutic Intervention;Time;Tissue Sample;Tissues;treatment planning;tumor;tumor diagnostic;tumor growth;tumor metabolism;tumor microenvironment;Tumor Tissue

PROJECT_TITLE: Quantitation of nutrient metabolism in brain tumor patients using advanced 13C isotopomer technology

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: NARRATIVE The burden of chronic kidney disease places enormous physical, psychological, social and economic stress on the affected children, their families and our society. This Pediatric Center of Excellence in Nephrology was designed to foster advances in knowledge, new methodologies, training and collaborations in an inclusive and diverse multidisciplinary environment to improve the management of infants and children with renal and urological diseases.

PI_NAMEs: GOMEZ, ROBERTO ARIEL (contact)

PROGRAM_OFFICER_NAME: GIPSON, DEBBIE SUE

PROJECT_TERMS: Adult;Advisory Committees;Affect;Architecture;arteriole;asporin;Award;Bioinformatics;Blood Vessels;candidate selection;Cardiovascular system;Cell Differentiation process;Cell Fate Control;Cells;Child;Childhood;Chronic;Chronic Kidney Failure;Clinical and Translational Science Awards;clinically relevant;Collaborations;collaborative environment;Communities;Country;data repository;design;Development;Disease;Economics;Education;Educational workshop;Embryo;Endowment;Environment;Epigenetic Process;epigenomics;Faculty;Family;fetal;FGF2 gene;Fostering;Funding;Goals;graduate student;Guidelines;Health;Hematology;high school;Homeostasis;Human Resources;hypoperfusion;improved;Individual;infancy;Infant;Injury to Kidney;Institution;interdisciplinary approach;interest;Invaded;Investigation;Joints;Kidney;Kidney Diseases;Knowledge;Laboratories;Letters;Life;Maintenance;mesangial cell;Methodology;Minority;Minority Participation;Mission;multidisciplinary;National Center for Advancing Translational Sciences;nephrogenesis;Nephrology;Newsletter;North Carolina;novel;Outcome;Participant;Pathology;Pericytes;Phenotype;Postdoctoral Fellow;postnatal;Prevention;Principal Investigator;Procedures;Process;progenitor;programs;psychologic;Regulation;Renal Hypertension;Renin;Request for Proposals;Research;Research Institute;Research Personnel;Research Project Grants;Research Support;Research Training;Resources;Role;Scientist;Services;Signal Transduction;Smooth Muscle;Smooth Muscle Myocytes;social;Societies;stem cells;Stress;Students;Study Section;success;symposium;Talents;Technical Expertise;Testing;TNFSF15 gene;Training;transcriptomics;translational health science;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Universities;urologic;Urologic Diseases;Vascular Smooth Muscle;Virginia;web site;Woman;Work

PROJECT_TITLE: Regulation of Cell Fate during Kidney Development and Disease


NIH_SPENDING_CATS: Kidney Disease;Pediatric

PROJECT_TERMS: Address;Adult;Advisory Committees;Area;Award;Awareness;Big Data to Knowledge;big-data science;Bioinformatics;Cardiovascular system;Cell Fate Control;Cells;Charge;Child;Childhood;Collaborations;Committee Members;Communities;Cultural Diversity;Data Science;Development;Diagnostic;Education;Educational workshop;Elements;Ensure;Environment;epigenomics;equity, diversity, and inclusion;Facebook;Fostering;fundamental research;Funding;Future;Genomics;Goals;Grant;Health Professional;Home;improved;Individual;Inflammation;Institution;interest;International;Kidney;Kidney Diseases;Knowledge;Laboratories;Maintenance;meetings;Mentors;Minority Groups;Minority Participation;Minority Recruitment;Mission;Modernization;multidisciplinary;National Center for Advancing Translational Sciences;nephrogenesis;Nephrology;North Carolina;operation;Pediatric Research;Preventive;Principal Investigator;programs;Public Health;Reagent;Recommendation;recruit;Research;research facility;Research Institute;Research Personnel;Schools;Scientist;Series;Structure;Supervision;symposium;Technology;Therapeutic;TNFSF15 gene;Training;Training Programs;transcriptomics;translational health science;Twitter;Underrepresented Minority;United States National Institutes of Health;Universities;Virginia;Vision;Visit;Wages;web site;Workplace

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Chronic Pain;Interstitial Cystitis;Neurosciences;Pain Research;Urologic Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative To date, research has mainly focused on the participation of afferent fibers of the pelvic nerve in the etiology of bladder pathology, such as Overactive Bladder (OAB) or Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS). However, the bladder is also innervated by hypogastric afferents, and little is known about how these afferents contribute to bladder function. Our project will anatomically and functionally map the peripheral fiber types and central projections of the nociceptive bladder afferent pathway in the hypogastric nerve, which could reveal the pathophysiological mechanisms underlying bladder pathology and direct research efforts to develop new drugs/devices targeting the sympathetic hypogastric afferent pathway.

PI_NAMEs: BECKEL, JONATHAN M (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Acetic Acids;afferent nerve;Afferent Pathways;Anatomy;Anesthesia procedures;Animals;Area;Automobile Driving;Bilateral;Bladder;Bladder Control;Bladder Diseases;Bladder Dysfunction;bladder pain;Brain;C Fiber;Central Nervous System;Chemicals;Clinical;Data;Devices;diagnostic strategy;diagnostic tool;Electric Stimulation;Electrophysiology (science);Esthesia;Etiology;experimental study;Felis catus;Fiber;FOS gene;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;Human;Image;Infection;Inflammation;Interneurons;Interoception;Interstitial Cystitis;Irritants;irritation;Limb structure;Location;Lower urinary tract;Lumbar spinal cord structure;Maps;Mediating;Methods;Microelectrodes;Micturition Reflex;micturition urgency;Nerve;Neural Pathways;neuroregulation;Nociception;Nociceptors;novel diagnostics;novel therapeutics;Overactive Bladder;Pain;Pathologic;Pathology;Pathway interactions;Pattern;Pelvic Pain;Pelvis;Peripheral;Peripheral Nerve Stimulation;Physiological;Play;pressure;Reflex action;Research;Role;Sacral nerve;Saline;Sensory;Site;Spinal Cord;Stimulus;Stretching;Techniques;Testing;Travel;treatment strategy;Urination;Urine;Visceral pain

PROJECT_TITLE: Characterization of Hypogastric Afferent Pathway Involved in Urinary Bladder Function and Dysfunction

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Kidney Disease

PI_NAMEs: MEDRANO, SILVIA  (contact)

PROJECT_TERMS: Applications Grants;Area;Bioinformatics;bioinformatics resource;bioinformatics tool;Biological;Biomedical Research;Cell Fate Control;Cells;Cellular Structures;Childhood;ChIP-seq;Cleavage Under Targets and Release Using Nuclease;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;computer infrastructure;Consultations;cost effective;Data;Data Analyses;data to knowledge;Doctor of Philosophy;Education;Ensure;Epigenetic Process;epigenome;epigenomics;Equipment;experience;Funding;Gene Expression;Genes;Genetic Transcription;Goals;Human Resources;immunocytochemistry;In Situ Hybridization;Injury to Kidney;innovation;Institution;instrumentation;Kidney;Kidney Diseases;kidney repair;Knowledge;large scale data;Manuscripts;Mentorship;Mission;multiple omics;nephrogenesis;new technology;next generation sequencing;operation;Phenotype;Pilot Projects;Postdoctoral Fellow;Preparation;Research;Research Personnel;Research Project Grants;Resources;Scientist;Services;Signal Transduction;single cell ATAC-seq;single cell genomics;single-cell RNA sequencing;Students;summer student;Techniques;Technology;Therapeutic;Training;Training Programs;transcriptome;transcriptome sequencing;transcriptomics;Validation;Work;XCL1 gene

PROJECT_TITLE: Single-Cell Epigenomics, Transcriptomics, and Bioinformatics Core


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative This project expands the knowledge on pediatric patient safety by bringing together pediatricians, pediatric specialists, transport teams, parent representatives, design specialists, and engineers. Methodologies that will be used include clinical workflow process evaluation using quality improvement methodologies, and Lean UX and agile methodologies for the design and development of a machine learning augmented tools for transport monitoring and communication with real-time data models to enhance patient safety on inter-facility transports.

PI_NAMEs: UMOREN, RACHEL A (contact)

PROGRAM_OFFICER_NAME: RODRICK, DAVID

PROJECT_TITLE: Pediatric Transport Learning Laboratory

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


NIH_SPENDING_CATS: Genetics;Kidney Disease;Pediatric

PROJECT_TERMS: Ablation;Adolescent;Adult;Affect;Angiotensin Receptor;Angiotensin-Converting Enzyme Inhibitors;Animals;arterial lesion;Arteries;arteriole;Biological;Blood flow;Blood Pressure;Blood Pressure Monitors;Blood Vessels;Captopril;Cardiovascular system;Cell Communication;Cell Fate Control;Cell Lineage;Cell Nucleus;cell transformation;Cells;Child;Childhood;Chromatin;Chromatin Modeling;Chronic;Chronic Kidney Failure;clinically relevant;Comprehension;Cyclic AMP;Data;Dehydration;design;Development;Disease;Drug usage;Embryo;EP300 gene;epigenomics;Evolution;Extracellular Fluid;Fibrosis;Generations;Genes;Genetic Transcription;high risk infant;Histologic;Histones;Homeostasis;Human;Hypertension;Hypertrophy;Hypotension;Immunohistochemistry;imprint;inhibitor;Ischemia;jagged1 protein;Juxtaglomerular Cell;Kidney;Kidney Diseases;Kidney Failure;Knowledge;Laboratories;Lead;Length;Ligands;Maps;Measurement;Mediating;Medical;Morphology;Mus;Mutation;MYH11 gene;nephrogenesis;notch protein;novel;Pathologic;Pathway interactions;Pharmaceutical Preparations;Phenotype;Physiological;prevent;Production;progenitor;Proteinuria;Rattus;receptor;Renin;Renin-Angiotensin System;Reporter;senescence;sensor;Sequence Deletion;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Smooth Muscle Myocytes;Sodium;Stains;Testing;Time;transcriptome;Transferase;translational potential;Trees;valsartan;Vascular Diseases;Work

PROJECT_TITLE: Project #1: Chronic stimulation of renin cells and transformation of the kidney vasculature


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Changes in brain function are thought to underlie the development of obesity and type 2 diabetes. Neurons located in the lateral hypothalamic area control feeding behavior, energy homeostasis, and body weight, but their role in the development of obesity is unclear. Addressing lateral hypothalamic involvement in overeating will help us understand the neurocircuit mechanisms that control diet-induced obesity and will inform future therapeutic interventions.

PI_NAMEs: ROSSI, MARK ALLEN (contact)

PROJECT_TERMS: Ablation;Acute;Address;adverse outcome;Affect;Appetitive Behavior;Area;behavioral impairment;Body Weight;Body Weight decreased;Brain;Calcium;cell type;Central Nervous System;Chronic;Data;design;Desire for food;Development;Diet;diet-induced obesity;dietary control;Dissection;Eating;Eating Disorders;Electric Stimulation;Electrophysiology (science);Exhibits;experimental study;feeding;Feeding behaviors;Food;food consumption;Functional disorder;Future;Genetic Transcription;Glucose;Glucose Intolerance;Glutamates;Goals;hindbrain;Holography;Homeostasis;Human;Hyperactivity;Hyperphagia;Hypothalamic structure;Image;Impairment;in vivo;in vivo imaging;insight;Intake;Laboratories;Lateral;Lateral Hypothalamic Area;Measures;Mediating;Mediator;Metabolic;Metabolic Diseases;Metabolism;Microscopy;Modeling;Molecular;Monitor;multi-photon;multiphoton imaging;Mus;Nervous System control;Neuronal Dysfunction;Neurons;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutritional;Obese Mice;Obesity;obesity development;obesity treatment;obesogenic;Optics;Overnutrition;Pathogenesis;Pathology;Peripheral;Phenotype;Population;Regulation;Resolution;restoration;Role;Satiation;Signal Transduction;single cell mRNA sequencing;Slice;Structure;Synapses;Synaptic plasticity;targeted treatment;Testing;Tetanus Toxin;Therapeutic Intervention;two-photon;Weight Gain;Work

PROJECT_TITLE: Lateral Hypothalamic circuit dysfunction underlying the development of diet-induced obesity

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


PI_NAMEs: RAY, PATRICIO E. (contact)

PROJECT_TERMS: Adrenergic Agents;Affect;Angiotensin II;Angiotensin Receptor;Angiotensin-Converting Enzyme Inhibitors;arteriole;Biological Markers;Blood Vessels;Cell Fate Control;cell growth;cell type;Cells;Child;Chronic;Cyclic AMP;Deterioration;Development;dietary;Disease;Endocrine;Equilibrium;experimental study;Extracellular Fluid;FGF2 gene;Fibroblast Growth Factor;Fluid Balance;Gene Proteins;Growth;Growth Factor;high risk;Homeostasis;Hypertension;Hypertrophy;Hypokalemia;Hypotension;Impairment;improved;infancy;Infant;Injury to Kidney;Intake;Juxtaglomerular Cell;Kidney;Kidney Diseases;kidney fibrosis;kidney vascular structure;Lesion;Life;Mus;nephrogenesis;Pathogenesis;Pathway interactions;Perfusion;Phenotype;Physiological;Play;postnatal;Process;Proliferating;Proteins;RAS inhibition;Rattus;Receptors, Adrenergic, beta-1;recruit;Regulation;Renin;response;Role;Signal Pathway;Signal Transduction;Smooth Muscle;Smooth Muscle Myocytes;Sodium Chloride;stem cells;Stimulus;Testing;Time;time use;Tissues;transcriptome;transcriptomics;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;Transforming Growth Factors;urinary;Urine;Vascular remodeling;Vascular Smooth Muscle;wasting;Wasting Syndrome;Work

PROJECT_TITLE: Project 2: Defining how the TGF- /FGF2 axis alters the fate of renin producing and vascular smooth muscle cells under conditions that threaten homoeostasis in infancy


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Burden of Illness;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Depression;Dissemination and Implementation Research;Mental Health;Neurodegenerative;Palliative Care

ORG_CITY: BUFFALO GROVE

ORG_NAME: BRIGHTOUTCOME INC.

PHR: Project Narrative Despite progress in development of efficacious interventions to reduce stress, depression and burden for dementia caregivers, there has been scant focus on the challenges of broader implementation. In the proposed Phase II project we will further develop SAGE LEAF, a self- guided online positive emotion skills intervention for caregivers of people with Alzheimer’s disease and optimize it for delivery through caregiver-serving organizations.

PI_NAMEs: MOSKOWITZ, JUDITH T.;YANG, DERSHUNG  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: acceptability and feasibility;Administrator;Adoption;Alzheimer's Disease;Alzheimer's disease caregiver;Anxiety;Behavioral;care costs;care giving burden;care recipients;Caregiver Burden;caregiver interventions;Caregivers;caregiving;Caring;Cessation of life;Clinic;cognitive skill;cohort;commercialization;Communities;cost;dashboard;Dementia;dementia burden;Dementia caregivers;Development;Effectiveness;efficacious intervention;Electronics;emotion regulation;Emotions;Environment;Event;Family Caregiver;Feedback;Focus Groups;Fostering;Goals;gratitude;Health;health care service organization;Hour;Human Resources;implementation barriers;implementation strategy;improved;Individual;Intervention;Interview;Learning;Life;Loneliness;Maintenance;Marketing;Medical;Mental Depression;Mental Health;mindfulness;Outcome;Participant;Persons;Phase;physical conditioning;positive emotional state;pragmatic trial;programs;Progress Reports;prototype;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Research;Research Personnel;response;Risk;self-compassion;Shoulder;skills;social;Social isolation;Stress;stress reduction;success;Testing;Time;usability;virtual;Waiting Lists

PROJECT_TITLE: SAGE LEAF 2: An Online Self-Guided Positive Emotion Regulation Program to Reduce Alzheimer's Dementia Caregiver Burden Delivered through Caregiver-Serving Organizations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-C(10)B]


ORG_DEPT: GENETICS

PHR: NARRATIVE In all animals, the fertilized egg undergo activation of its own genome and the regulation of the maternally deposited instructions (mRNAs and proteins). This proposal studies how the vertebrate embryos organizes multiple players to undertake these tasks, with the goal of understanding basic conserved principles of how genes are regulated that can be applied to other systems, including reprogramming of the cellular fates and cancer.

PI_NAMEs: GIRALDEZ, ANTONIO J (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Affect;Age;Animals;Biological Assay;Cell Reprogramming;Cells;Chromatin Structure;Code;Deposition;Development;DNA;early pregnancy loss;Embryo;Embryonic Development;experimental study;Fertilization in Vitro;Gene Expression;gene regulatory network;Genes;Genetic Transcription;Genome;Goals;Human;human disease;imaging approach;in vivo;Individual;Infertility;insight;Instruction;Malignant Neoplasms;Maps;Maternal Messenger RNA;Mediating;Messenger RNA;Molecular;mRNA Decay;mRNA Stability;novel;Oncogene Activation;Output;Pathway interactions;Play;post pregnancy;Post-Transcriptional Regulation;Pregnancy;Process;programs;Proteins;Public Health;Reader;Regulation;Reporter;Repression;reproductive;Reproductive Health;RNA;Role;Shapes;Structure;System;tool;Translational Regulation;vertebrate embryos;Woman;zygote

PROJECT_TITLE: Molecular mechanisms of the maternal to zygotic transition

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Diabetes;Neurosciences;Pediatric;Rare Diseases

PHR: PROJECT NARRATIVE Congenital hyperinsulinism is the most common cause of persistent low blood sugar in infants and children and is associated with high rates of neurocognitive impairment. This project will examine trajectories of neurocognitive development in school-aged children with congenital hyperinsulinism and will guide future strategies to improve neurocognitive outcomes.

PI_NAMEs: ROSENFELD, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: Acceleration;Address;Advisory Committees;Affect;Age;age related changes;aged;Applications Grants;Award;Biostatistical Methods;Blood Glucose;Brain;career;Characteristics;Child;Childhood;Clinical;clinical phenotype;clinical practice;Clinical Trials;Cognition;cognitive development;critical period;Data Analyses;Dedications;Development;Diabetes Mellitus;Diffuse;Disease;Endocrinologist;Environment;Epidemiologist;Epidemiology;experience;Future;Goals;Growth;Hyperinsulinism;Hypoglycemia;improved;Infant;innovation;Intervention;Knowledge;Life;Liquid substance;longitudinal design;Longitudinal Studies;Measures;Mentored Patient-Oriented Research Career Development Award;Mentorship;Methods;Modeling;multidisciplinary;neonatal period;Neurocognitive;Neurocognitive Deficit;Outcome;Outcome Assessment;Outcome Measure;patient oriented research;Patient-Focused Outcomes;Pattern;Pediatric Hospitals;peer;Pennsylvania;Perinatal;Persistent Hyperinsulinemia Hypoglycemia of Infancy;Philadelphia;Physicians;Positioning Attribute;primary outcome;Principal Investigator;programs;Research;Research Design;Research Personnel;Resources;Risk;School-Age Population;Scientist;sex;skill acquisition;Socioeconomic Status;Statistical Methods;Stress;Time;Training;United States National Institutes of Health;Universities;Variant;Work

PROJECT_TITLE: Impact of Congenital Hyperinsulinism on Trajectories of Neurocognitive Function Across School Age