NIH_SPENDING_CATS: Cancer;Genetics;Uterine Cancer;Women's Health Research

ORG_CITY: COLUMBIA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: Although early-stage and low grade endometrial cancer generally exhibits a favorable prognosis, metastatic and recurrent endometrial cancer is incurable with currently available standard therapies for most women. Therefore, there is an urgent obligation to explore the mechanism of tumor metastasis and recurrence to further elucidate the progression of endometrial cancer. The experiments proposed in this application will employ the first preclinical animal model that closely resembles human endometrial cancer with distant metastasis and recurrence to identify new mechanistic targets that could dramatically improve therapeutic options for endometrial cancer.

PI_NAMEs: JEONG, JAE-WOOK  (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: Abdomen;Ablation;Acceleration;Adjuvant Therapy;Animal Model;atorvastatin;cancer cell;cancer recurrence;Cells;Cholesterol;cholesterol biosynthesis;Data;Development;Diagnosis;Disease;Distant Metastasis;Endometrial Carcinoma;Estrogens;Exhibits;experimental study;FDA approved;Gene Expression;Gene Targeting;Genes;Genetically Engineered Mouse;High Fat Diet;high risk;Histologic;Human;Hysterectomy;improved;in vivo;innovation;Knowledge;Lung;Malignant Female Reproductive System Neoplasm;Mediator;Metastatic Endometrial Carcinoma;Metastatic/Recurrent;Mitogens;Molecular Profiling;mouse model;mTOR inhibition;Mus;Mutant Strains Mice;Mutate;Mutation;Neoplasm Circulating Cells;Neoplasm Metastasis;novel;novel therapeutics;Operative Surgical Procedures;overexpression;Pathway interactions;Patients;pre-clinical;Preclinical Testing;prevent;Primary Neoplasm;Progesterone;Prognosis;Proto-Oncogene Proteins c-akt;PTEN gene;Recurrence;Recurrent tumor;Resolution;Role;Signal Transduction;Staging;Survival Rate;Testing;Therapeutic;transcriptome;tumor;tumor progression;Tumor Suppressor Genes;tumorigenic;Uterus;Visualization;Woman;Work

PROJECT_TITLE: The role of cholesterol biosynthesis in metastatic and recurrent endometrialcancer

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: BAR HARBOR

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: Recent discoveries indicate that subsets of human NK cells mediate adaptive immunity to HIV-encoded antigens; however, NK cell receptor repertoires diversify throughout life, and high NK cell receptor repertoire diversity is associated with increased risk of HIV acquisition. These data present a challenge for vaccine design, as both protective NK cell-mediated memory responses and potentially harmful NK cell receptor repertoire diversifications are consequences of antigen exposures. To solve this problem, this study will identify the NK functional subsets that are most responsive to HIV, and their mechanisms of host protection from HIV disease, providing the rationale to develop novel vaccines that exploit the antiviral effector functions of NK cells to protect humans from HIV infection while avoiding harmful activity.

PI_NAMEs: PAUST, SILKE  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJALI

PROJECT_TERMS: Activities of Daily Living;Adaptive Immune System;adaptive immunity;Adoptive Transfer;Algorithms;Antibodies;Antigens;Attention;B-Lymphocytes;Biological Assay;CD94 Antigen;Cell Differentiation process;Cell surface;Cell Surface Receptors;Cells;Cellular biology;Collaborations;comparison control;Complex;Data;Data Analyses;Disease;Effector Cell;efficacy evaluation;Etiology;experience;Exposure to;Flow Cytometry;Glycoproteins;Goals;Hepatic;Herpesvirus Type 3;HIV;HIV envelope protein;HIV Infections;HIV vaccine;Human;human data;human genomics;humanized mouse;Immunologic Markers;Immunologic Memory;Immunologist;improved;In Vitro;in vivo;Individual;Infection;Knowledge;Learning;Life;Lymphocyte;Measures;Mediating;member;Memory;mouse model;Names;Natural Killer Cells;Nature;neoplastic cell;novel;novel vaccines;Outcome;Pathway interactions;peripheral blood;pharmacologic;Phenotype;Population;Pre-Clinical Model;Proteins;Publishing;receptor;response;Risk;Sampling;Scientist;Shapes;Signal Transduction;single cell sequencing;T-Lymphocyte;Testing;Tissues;transcription factor;transcriptome;Vaccinated;Vaccination;Vaccine Design;vaccine development;vaccine efficacy;vaccine evaluation;Vaccines;Viral;viral genomics;Viral Physiology

PROJECT_TITLE: How antigen exposure shapes the subsequent NK cell response to HIV


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

ORG_CITY: BETHESDA

ORG_NAME: HENRY M. JACKSON FDN FOR THE ADV MIL/MED

ORG_STATE: MD

PHR: PROJECT NARRATIVE The proposed research will elucidate molecular mechanisms through which WT RAS signaling drives transformation of cancers harboring specific mutant RAS isoforms, including the relative contribution of SOS1 and SOS2. Defining the mutant RAS-isoform specific requirements of WT RAS signaling will help us better understand the landscape of RAS mutated tumors and allow us to identify specific vulnerabilities for therapeutic intervention in an isoform-specific manner. Hence, this research will inform novel therapeutic approaches for eradicating subsets of RAS mutated tumors with genotype-dependent precision.

PI_NAMEs: KORTUM, ROBERT  (contact)

PROGRAM_OFFICER_NAME: GHOSH-JANJIGIAN, SHARMISTHA

PROJECT_TERMS: Anoikis;Binding;biobank;Biological Assay;Biological Models;cancer cell;Cancer cell line;Cell Line;Cell Physiology;Cell Survival;Cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Colon Carcinoma;Cytoprotection;Data;Dependence;Drug Synergism;Feedback;Genetic Models;Genetically Engineered Mouse;Genotype;Human;Impairment;in vivo;Individual;inhibitor;Knock-out;KRAS2 gene;Malignant Neoplasms;Mediating;MEK inhibition;MEKs;Molecular;mutant;Mutate;Mutation;mutational status;novel;novel therapeutic intervention;Oncogenic;Organoids;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;PI3K/AKT;PIK3CA gene;PIK3CG gene;Pre-Clinical Model;preclinical trial;predicting response;prevent;Proliferating;Protein Isoforms;RAS genes;RAS inhibition;Ras Inhibitor;ras Proteins;Ras/Raf;reconstitution;Reporting;Research;Resistance;Role;Signal Transduction;Structure;synergism;System;targeted agent;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapeutically effective;therapy resistant;Tipifarnib;Toxic effect;tumor;tumorigenesis;Xenograft procedure

PROJECT_TITLE: Isoform-specific signaling as a determinant of RAS-driven oncogenesis

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Precision Medicine;Rare Diseases;Stomach Cancer

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: Narrative  Success of the proposed research will unveil in-depth mechanisms of ferroptosis, as well as its functional communication with various cancer-relevant intercellular and intracellular molecular events. The proposed research will also lead to the identification of biomarkers that predict cancer responsiveness to future ferroptosis- inducing cancer therapy.

PI_NAMEs: JIANG, XUEJUN  (contact)

PROGRAM_OFFICER_NAME: SALNIKOW, KONSTANTIN

PROJECT_TERMS: Apoptosis;Apoptotic;Automobile Driving;Biochemical;Bioinformatics;Biological;Biology;biomarker identification;cancer cell;cancer genomics;Cancer Patient;cancer therapy;Candidate Disease Gene;carcinogenesis;Cell Adhesion Molecules;Cell Death;Cells;Clinical;clinically significant;Communication;Development;Disease;Down-Regulation;E-Cadherin;effective therapy;Epithelial Cells;Epithelium;Event;Future;Gastric Adenocarcinoma;gastric cancer cell;Gene Mutation;Genes;genetic approach;Genetic Transcription;Genetically Engineered Mouse;genome-wide;genomic data;Grant;in vivo;inhibitor;insight;Investigation;Iron;Lipid Peroxidation;loss of function;loss of function mutation;Malignant - descriptor;Malignant Neoplasms;malignant stomach neoplasm;Mediating;Mesenchymal;Mesothelioma;Metabolism;Missense Mutation;Modality;Molecular;mouse model;mutant;Mutate;Mutation;Neoplasm Metastasis;Neurofibromin 2;novel;Oncogenic;Oncoproteins;Organoids;Pathologic;Pathway interactions;Patients;pharmacologic;Play;pre-clinical;Precision therapeutics;predicting response;predictive marker;Predisposition;promoter;Property;Publishing;Regulation;Research;Resistance;Role;screening;Signal Pathway;Signal Transduction;specific biomarkers;Structure;success;Testing;TFRC gene;The Cancer Genome Atlas;Therapeutic;Transcription Coactivator;tumor;Tumor Suppression;Tumor Suppressor Proteins;tumorigenesis;Validation;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Ferroptosis and Cancer Cell Signaling

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ADMINISTERING_IC: EB

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative The Advanced Technologies-National Center for Image guided Therapy (AT-NCIGT) is a research and technology center with the mission of advancing patient care, by developing novel innovative tools for image guided Therapy (IGT). The three technologies encompass Imaging Cancer Heterogeneity, Deep learning and Intraoperative devices for image guided therapy which will be investigated both individually and in cross TR &D combinations. We will disseminate all technologies through a national network of collaborators, making these discoveries available to the larger medical community.

PI_NAMEs: TEMPANY, CLARE M (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: 3-Dimensional;Acceleration;Acute;Algorithms;Architecture;Atlas of Cancer Mortality in the United States;Augmented Reality;big-data science;Biomedical Research;biomedical resource;Biopsy Specimen;Blood;Brain;Brain Neoplasms;brain surgery;cancer care;cancer heterogeneity;cancer imaging;cancer therapy;Cells;Characteristics;Communities;Compensation;Complex;Computer software;Computer Vision Systems;Conventional Surgery;Data;data curation;data integration;Dedications;deep learning;design;Development;Devices;Diffusion;digital;Discipline;Disease;Early Diagnosis;Effectiveness;Evolution;Foundations;Goals;Healthcare;Heterogeneity;Histopathology;Image;image guided;image guided therapy;image registration;Imaging Device;imaging facilities;imaging modality;Imaging Techniques;Immunotherapy;Implant;improved;in vivo;in vivo monitoring;Individual;Information Retrieval;Infrastructure;innovation;Intervention;Interventional radiology;ion mobility;Knowledge;Lesion;Longitudinal Studies;Lung;machine learning algorithm;Magnetic Resonance;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Maps;mass spectrometer;mass spectrometric imaging;Medical;Medicine;Metabolic;Metabolic Marker;Metabolism;Metadata;Methods;microdevice;Microscopic;Mission;Modeling;Molecular;Morphology;Nanotechnology;Navigation System;Needles;Neoplasm Metastasis;neoplastic;new technology;novel;novel strategies;Operating Rooms;Operative Surgical Procedures;Patient Care;Patient-Focused Outcomes;Pattern;personalized cancer therapy;personalized medicine;Physiologic pulse;precision medicine;Procedures;Prostate;prostate biopsy;protocol development;Radiation Oncology;Recurrence;Research;Resistance;response;Retrieval;Risk Assessment;Sampling;Services;Signal Transduction;Source;Specimen;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Speed;surgery outcome;T2 weighted imaging;Technology;technology platform;technology research and development;technology validation;Testing;Time;Tissue imaging;tissue oxygenation;Tissue Sample;Tissues;tool;trait;tumor;tumor heterogeneity;tumor hypoxia;ultra high resolution;Visualization

PROJECT_TITLE: Advanced Technologies - National Center for Image Guided Therapy (AT-NCIGT)


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

PROJECT_TERMS: Acute;Advisory Committees;Algorithms;Articulation;Attention;Beds;big-data science;Biomedical Research;biomedical resource;Cancer Biology;cancer care;cancer heterogeneity;cancer imaging;care providers;Clinical;Collaborations;Collection;Communication;Communities;Consultations;Data;data curation;data integration;Data Set;Dedications;deep learning;Development;Devices;digital;Early Diagnosis;Ensure;Equipment;Event;Evolution;experience;Feedback;Funding;Geographic Distribution;Geography;Goals;Grant;Group Meetings;Guidelines;Healthcare;Heterogeneity;Human;Image;image guided;image guided therapy;Imaging Device;imaging facilities;imaging modality;Immunotherapy;Information Retrieval;innovation;interest;Investigation;Knowledge;Leadership;Lesion;Manuscripts;Medical;meetings;Mentors;Mission;Monitor;Nanotechnology;Neoplasm Metastasis;neoplastic;new technology;novel;operation;Operative Surgical Procedures;Participant;Patient Care;Patients;Pattern;personalized cancer therapy;personalized medicine;Phase;Policies;precision medicine;Procedures;programs;Publications;Recurrence;Research;Research Activity;Research Design;Research Personnel;research study;Resistance;Resources;response;Services;shared decision making;skills;sound;Strategic Planning;Structure;Technology;technology research and development;Testing;Time;Tissues;tumor;United States National Institutes of Health;Vision;Work

PROJECT_TITLE: Administration Core


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Genetics;Lung;Orphan Drug;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: DURHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Idiopathic pulmonary fibrosis (IPF) and other progressive fibrosing interstitial lung diseases (PF-ILDs) are incurable, scarring lung disorders that lead to respiratory failure and early death despite current therapies. This proposal will evaluate a novel pathway in the development and progression of IPF and other PF-ILDs in order to determine its prognostic and therapeutic potential. Knowledge gained from this study is likely to provide new insights into potential biomarkers of PF-ILD progression and acute exacerbations that will ultimately support generation of more effective therapies leading to improved outcomes in PF-ILD.

PI_NAMEs: SWAMINATHAN, APARNA CHANDRA (contact)

PROGRAM_OFFICER_NAME: CHARYA, ANANTH VELUGALETI

PROJECT_TERMS: Acceleration;Acute;Admission activity;Animal Model;Area;biobank;Biological;Biological Markers;Biology;Biometry;career development;case control;Case/Control Studies;Cessation of life;Chronic;Classification;Clinical Data;Clinical Research;Clinical Trials;clinically relevant;Code;cohort;Complement;Complement 3b;Complement 4b;Complement 5a;Complement Activation;Complement component C1r;complement pathway;Cox Proportional Hazards Models;Data;Data Set;Deterioration;Development;Disabling;Disease Progression;disorder risk;DNA;Dyspnea;effective therapy;Enrollment;Epithelial Cells;Etiology;Event;exome sequencing;experience;externship;Fibroblasts;Fibrosis;fibrotic interstitial lung disease;fibrotic lung;follow-up;Funding;Future;Generations;Genes;Genetic;Genetic Polymorphism;Genetic Risk;genetic risk factor;genetic variant;Genetic Variation;genome sequencing;Goals;hands on research;Hospitalization;Host Defense;idiopathic pulmonary fibrosis;Immunology;improved outcome;Inflammation;insight;Institution;Intervention;Knowledge;Laboratories;Lead;Linear Regressions;Logistic Regressions;Lung;lung development;Lung Diseases;Lung Transplantation;Measures;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Messenger RNA;Modeling;mortality;multidisciplinary;novel;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;personalized medicine;Phenotype;Plasma;Positioning Attribute;potential biomarker;prevent;prognostic;prospective;Prospective cohort;Proteins;Pulmonary Fibrosis;pulmonary function decline;receptor expression;recruit;Registries;Regression Analysis;Research;research and development;Research Institute;Research Personnel;Research Training;respiratory;Respiratory Failure;Risk;Role;Sampling;Structure of parenchyma of lung;symposium;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;Time;Tissues;Training;Transcript;Translational Research;Variant;Vital capacity;whole genome

PROJECT_TITLE: Complement Pathway Activation in Idiopathic Pulmonary Fibrosis and other Progressive Fibrosing Interstitial Lung Diseases

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_DEPT: BIOLOGY

ORG_NAME: HUNTER COLLEGE

PHR: Project Narrative/Relevance Statement The understanding of gene regulation in the nervous system holds the promise of breakthrough treatments brain disorders. Here, our schemes for analyzing odorant receptor gene expression in the mammalian olfactory system will put us on the forefront of solving these problems.

PI_NAMEs: FEINSTEIN, PAUL  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Address;Afferent Neurons;Alleles;Binding;Binding Sites;Biochemical;Biochemistry;Brain Diseases;Cell Nucleus;cell type;Cells;ChIP-seq;chromatin immunoprecipitation;Code;Complex;crosslink;Data;Deposition;derepression;Development;Distant;Elements;Enhancers;Epigenetic Process;epigenetic silencing;Exhibits;Experimental Genetics;experimental study;Gene Cluster;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Diseases;genetic element;Genetic Transcription;Genome;Greek;histone modification;homeodomain;Island;Location;Mammals;Messenger RNA;Modeling;Modification;Molecular;Mus;Nature;Nervous System;Nose;Nuclear;Odorant Receptors;olfactory nuclei;Olfactory Pathways;olfactory sensory neurons;Phenotype;Play;Population;Process;promoter;Property;Proteins;receptor expression;Receptor Gene;Role;Scheme;selective expression;Site;Sucrose;Testing;Time;tool;transcription factor;Transcriptional Activation;Transgenes;Work

PROJECT_TITLE: Defining the components of olfactory singular expression

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Machine Learning and Artificial Intelligence;Neurosciences;Orphan Drug;Precision Medicine;Prostate Cancer;Rare Diseases;Urologic Diseases;Women's Health Research

PI_NAMEs: AGAR, NATHALIE YR (contact)

PROJECT_TERMS: 3-Dimensional;Address;Agar;Architecture;Biopsy;Blood;Brain Mapping;Brain Neoplasms;cancer heterogeneity;cancer imaging;cancer therapy;Categories;Cells;Characteristics;chemotherapy;Clinical Data;Clinical Management;Complement;correctional system;Data;data analysis pipeline;Dedications;deep learning;design;Development;Diagnosis;Diagnostic Procedure;Diffusion;Doctor of Philosophy;dosage;Effectiveness;Environment;Evaluation;Failure;Female Genital Neoplasms;Frozen Sections;Future;Gene Expression;genetic makeup;Genotype;Gland;Goals;Heterogeneity;high dimensionality;Histopathology;Hypoxia;Image;image guided;image guided therapy;imaging facilities;Imaging technology;improved;Individual;individualized medicine;instrument;ion mobility;Knowledge;Location;machine learning method;Magnetic Resonance;Magnetic Resonance Imaging;Malignant neoplasm of cervix uteri;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;mass spectrometer;mass spectrometric imaging;Measurement;Mediating;men;Metabolic;Metabolic Marker;metabolic profile;Metabolism;metabolomics;Methods;Microscopic;Molecular;Nature;neoplastic cell;novel;novel strategies;Operative Surgical Procedures;overtreatment;Oxygen;Patient Care;Patients;personalized medicine;Phenotype;Physiologic pulse;Plague;precision medicine;Procedures;prostate biopsy;prostate lesions;Prostatic Neoplasms;protocol development;Protocols documentation;Radiation therapy;radiomics;Reproducibility;respiratory challenge;Risk Assessment;Role;Sampling;Signal Transduction;Specimen;Spectrometry;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Speed;T2 weighted imaging;targeted imaging;targeted treatment;Techniques;Technology;technology platform;technology validation;Testing;Therapeutic Agents;Time Management;Tissue imaging;tissue oxygenation;Tissues;trait;Translating;treatment planning;tumor;Tumor Burden;tumor heterogeneity;tumor hypoxia;Tumor Volume;ultra high resolution

PROJECT_TITLE: TRD 1 - Imaging Cancer Heterogeneity


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Cannabidiol Research;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Genetics;Natural Products;Nutrition;Patient Safety;Therapeutic Cannabinoid Research;Transplantation

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative The commercial availability of cannabidiol, or CBD oil, has increased in the United Stated and this supplement has the potential to cause a variety of drug-drug interactions, including in solid organ transplant recipients who receive tacrolimus to prevent rejection. Through a series of pharmacokinetic and pharmacodynamics assays, this proposal will identify gene-drug and drug-drug interactions (DDI), including those that place transplant recipients at risk for increased toxicity related to their immunosuppression. The information learned in these studies will help to inform practitioners as to whether cannabidiol needs to be avoided in transplant recipients and how to appropriately adjust doses of CBD and immunosuppression in order to improve health outcomes and long-term treatment success in this high-risk population.

PI_NAMEs: EADON, MICHAEL THOMAS (contact)

PROGRAM_OFFICER_NAME: HOPP, CRAIG

PROJECT_TERMS: Address;Affect;African American population;Agriculture;Allografting;American;Animal Model;Area Under Curve;Asian;Biological Assay;Cannabidiol;Cannabis;Case Study;Cells;Chronic Kidney Failure;chronic pain management;Clinical;Clinical Trials;clinically relevant;Complement;Cross-Over Studies;CYP3A4 gene;CYP3A5 gene;Data;Dose;Drug Interactions;Drug Kinetics;Drug Metabolism Inhibition;Enzymes;Epidiolex;Epilepsy;Ethics;European;Exclusion;experimental study;Explosion;Exposure to;FDA approved;Flow Cytometry;Gene Expression Profile;Genes;Genotype;Glean;Goals;Health;Hepatic;high risk population;Human;Immune;Immune system;Immunologics;Immunology;immunosuppressed;Immunosuppression;Immunosuppressive Agents;improved;In Vitro;Individual;infection risk;inhibitor;interest;Investigation;Ketoconazole;knock-down;Learning;Liver Microsomes;Lymphocyte;Lymphocyte Subtypings;Mediator;Metabolism;Nutraceutical;nutrition;Oils;Organ;organ transplant recipient;Outcome;Patients;Pharmaceutical Preparations;Pharmacodynamics;Pharmacogenomics;pharmacokinetics and pharmacodynamics;Phenotype;pill;Population;prevent;primary outcome;Race;Regulatory T-Lymphocyte;Renal function;Research;Risk;safety assessment;Series;single cell sequencing;Small Interfering RNA;Solid;Study models;success;Tacrolimus;Testing;Toxic effect;Transplant Recipients;Transplantation;United States;volunteer;Vulnerable Populations;Work

PROJECT_TITLE: Drug-gene-nutraceutical interactions of cannabidiol

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Emergency Care

ORG_CITY: PITTSBURGH

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative: There are unique challenges to conducting research in emergency care, and few training programs directly address these challenges. This program offers interdisciplinary training to provide early-career clinical scientists with didactic and experiential training in clinical emergency care research. We will increase the number of highly qualified physicians and scientists working to improve emergency care for the public.

PI_NAMEs: CALLAWAY, CLIFTON W. (contact);YEALY, DONALD M

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Emergency Medicine;Research Training

PROJECT_TITLE: Emergency Medicine Research Training

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Data Science;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Prostate Cancer;Rare Diseases;Urologic Diseases

PI_NAMEs: WELLS, WILLIAM M. (contact)

PROJECT_TERMS: Acoustic Neuroma;Address;annotation  system;anti-cancer research;Brain;Brain imaging;brain magnetic resonance imaging;Brain Neoplasms;Cancerous;Classification;clinical application;Clinical Data;clinically significant;Collaborations;Collection;Communities;coping;Data;data acquisition;data harmonization;data modeling;Data Set;deep learning;deep learning algorithm;deep learning model;design;detection method;Disease;Evaluation;Excision;Gleason Grade for Prostate Cancer;Goals;heterogenous data;Histopathology;Hospitals;Image;image guided intervention;image guided therapy;image registration;imaging facilities;imaging informatics;Imaging problem;Informatics;Infrastructure;Label;Lesion;Lung;Lung CAT Scan;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Manuals;Maps;Medical Imaging;Metadata;Methods;Modeling;Multi-Institutional Clinical Trial;neurosurgery;Nose;novel;open source;Operative Surgical Procedures;Performance;Pituitary Gland;Probability;prospective;Prostate;prostate biopsy;prostate cancer model;Readability;Research;Scanning;success;supervised learning;System;Technology;Therapeutic Studies;three dimensional structure;tool;Training;training data;transfer learning;Ultrasonography;Work

PROJECT_TITLE: TRD 2 - Deep Learning


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Comparative Effectiveness Research;Diabetes;Health Services;Prevention;Primary Health Care

PHR: Project Narrative Cost-related medication restrictions may reduce the effectiveness of glucose-lowering medications among real- world patients with diabetes. The proposed research will generate new scientific knowledge the feasibility of an educational outreach intervention to reduce cost-related restrictions and improve evidence-based medication use. This research can help patients with type 2 diabetes and their healthcare providers make better treatment decisions to improve health outcomes.

PI_NAMEs: LUO, JING  (contact)

PROGRAM_OFFICER_NAME: BURCH, HENRY B

PROJECT_TERMS: Academic Detailing;acceptability and feasibility;Address;Adherence;Agonist;Award;barrier to care;basal insulin;burnout;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;career;career development;Clinical;clinical outcome measures;Cluster randomized trial;Code;cohort;Community Practice;copayment;cost;Cost Sharing;Data;Databases;Deductibles;design;Development Plans;Diabetes Mellitus;Drug Prescriptions;Education and Outreach;Educational workshop;Effectiveness;Enrollment;Event;evidence base;experience;follow-up;Formularies;Foundations;Funding;GLP-I receptor;Glucose;Glucose Transporter;Goals;Guidelines;Health;Health Insurance;Health Personnel;Health system;improved;inhibitor;Insurance Carriers;Intervention;Interview;Knowledge;Measures;Medical;Medicare;medication compliance;Medicine;Mentors;Mentorship;Methods;Modeling;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pilot test;Policies;poor health outcome;Price;primary care provider;primary care setting;prior authorization;Process;Provider;Recommendation;recruit;Reporting;Research;Research Personnel;Risk;Risk Factors;Risk Reduction;Sodium;Structure;Testing;theories;Training;Training Activity;Transcript;Uninsured Medical Expense

PROJECT_TITLE: Developing a provider-facing intervention to address cost-related medication restrictions and improve medication use in patients with type 2 diabetes

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative  Currently, more than 250 million humans worldwide are infected with schistosomes, flatworms in the genus Schistosoma, and approximately 20 million humans suffer from severe morbidity due to schistosomiasis. Humans become infected after exposure to larval parasites (cercariae) that are produced by infected snails in freshwater habitats. This project proposes and evaluates novel ecological hypotheses that could improve the prediction and control of a parasite causing major global health burden.

PI_NAMEs: CIVITELLO, DAVID JAMES (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TITLE: Resource competition drives natural and rebound dynamics of snails and schistosomes

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Adolescents with severe obesity experience significant physical and mental health morbidity, stigma, and premature death. Metabolic and bariatric surgery (MBS) is the most potent treatment available; however, a significant proportion of youth experience ongoing persistent obesity or weight regain after MBS without clear physiologic predictors, which may lead to residual cardiometabolic, mechanical, and psychological risks that must be effectively managed long-term. In the proposed study, we will collect rigorous longitudinal physiologic measures of gut peptides, insulin sensitivity, and cardiovascular structure/function not previously reported in youth after MBS, and will perform the first randomized, controlled trial of semaglutide post-MBS among youth with suboptimal BMI reduction, which in aggregate will refine the definition of MBS success and establish the feasibility and initial efficacy of semaglutide as a potential postoperative treatment adjunct.

PI_NAMEs: MOORE, JAIME M. (contact)

PROJECT_TERMS: Adherence;Adolescence;Adolescent;Adult;Affect;Age;Agonist;arterial stiffness;bariatric surgery;Basal metabolic rate;Behavioral;Biological;Blood Pressure;Blood Pressure Monitors;Body Composition;Body mass index;Body Weight;Body Weight decreased;Cardiac;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;career development;Cessation of life;Childhood;Clinical;Clinical Trials;cohort;comorbidity;Data;Desire for food;Development Plans;diagnostic tool;Disease remission;Double-Blind Method;double-blind placebo controlled trial;Dual-Energy X-Ray Absorptiometry;Eating Behavior;Echocardiography;energy balance;Environment;experience;Fasting;Fatty acid glycerol esters;Funding;Future;Gastrectomy;Gastric Inhibitory Polypeptide;gastrointestinal;ghrelin;GLP-I receptor;glucagon-like peptide 1;Goals;Grant;Health;Health Benefit;heart rate variability;Hispanic;Hour;Hypertension;improved;Indirect Calorimetry;Individual;Injectable;insulin secretion;insulin sensitivity;Intervention;Intervention Trial;Learning;Life Style;Link;Measures;Mechanics;Medicine;Mental Health;Metabolic;Methods;Morbid Obesity;Morbidity - disease rate;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Obesity;obesity in children;Operative Surgical Procedures;Outcome;pediatric department;Peptide YY;Peptides;Pharmaceutical Preparations;Pharmacotherapy;phase 2 designs;Phenotype;physical conditioning;Physiologic pulse;Physiological;Physiology;Placebos;Postoperative Period;predicting response;Predictive Factor;premature;preservation;professor;prospective;Prospective Studies;Protocols documentation;psychologic;Publications;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research;Research Design;Residual state;response;Risk;Risk Factors;Risk Marker;Risk Reduction;risk stratification;Satiation;Social Environment;social stigma;Solid;standard of care;Stroke;Structure;success;Testing;therapy design;Training;Weight;Weight maintenance regimen;Youth

PROJECT_TITLE: Physiologic response to bariatric surgery and the impact of adjunct semaglutide - in adolescents (the PRESSURE trial)


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prostate Cancer;Urologic Diseases

PI_NAMEs: HATA, NOBUHIKO  (contact)

PROJECT_TERMS: 3-Dimensional;Ablation;Address;Algorithms;Anatomy;Architecture;arm;Augmented Reality;Biopsy;Brain;brain tissue;Cancer Patient;Chemical Engineering;Clinical;Clinical Protocols;Clinical Research;Collaborations;Communities;Compensation;Computer software;Computer Vision Systems;controlled release;Data;Descriptor;design;Development;Device Designs;Device or Instrument Development;Devices;Diagnosis;Disease;Dose;drug candidate;drug sensitivity;Ensure;Event;Excision;Extraprostatic;Formulation;Future;Goals;Hospitals;Image;image guided;image guided intervention;image guided therapy;image reconstruction;image registration;Imaging Device;imaging facilities;imaging modality;Implant;implantation;improved;In Situ;in vivo;Individual;innovation;innovative technologies;insight;interstitial;Intervention;Laparoscopes;Lasers;Lead;Lung;Machine Learning;machine learning algorithm;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Maps;Measurement;Mechanics;Medical Device;Methods;microdevice;Modeling;Monitor;Multimodal Imaging;Navigation System;Needle biopsy procedure;Needles;novel;novel therapeutics;Operating Rooms;Operative Surgical Procedures;Pathologic;Patients;Pattern;personalized medicine;Pharmaceutical Preparations;Phase;Phenotype;Play;Polymers;precision drugs;precision medicine;predictive marker;programs;Prostate Ablation;prostate biopsy;prostate lesions;prototype;radiologist;Research;Resolution;response;Retrieval;Sampling;Shapes;simulation;Site;Software Tools;Surface;Surgeon;System;Systemic Therapy;systemic toxicity;targeted imaging;Techniques;Technology;Testing;Tissues;tool;Training;Treatment Efficacy;tumor;tumor heterogeneity;Validation;virtual reality environment;Visualization;Woman;X-Ray Computed Tomography

PROJECT_TITLE: TRD 3 - Enabling Technologies for Intraprocedural Guidance


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: OMAHA

ORG_NAME: OMAHA VA  MEDICAL CENTER

ORG_STATE: NE

PHR: The risks of severe disease or death from bacterial pneumonia are far worse in individuals with pre-existing lung disease, and it has been long established that alcohol use disorders (common in the Veterans’ population) lead to increased lung infections due to compromised innate lung defense. While reactive aldehydes are a source of this lung injury, their source and mechanism of action remains unknown. This study will define which at-risk conditions particularly impact those with AUD and their unique needs in order to empower clinical preventive care.

PI_NAMEs: WYATT, TODD A (contact)

PROJECT_TERMS: 3-Dimensional;Acetaldehyde;active duty;Address;adduct;Adhesions;airway epithelium;Alcohol abuse;Alcohol consumption;Alcohol dehydrogenase;alcohol exposure;alcohol misuse;alcohol research;alcohol use disorder;Alcohols;Aldehydes;Animal Feed;Animal Model;antimicrobial;Bacteria;Bacterial Infections;Bacterial Model;Bacterial Pneumonia;Binding;biobank;career;Cell model;Cells;Cessation of life;Characteristics;Chronic Obstructive Pulmonary Disease;cigarette smoke;Cigarette Smoker;cigarette smoking;Cilia;Clinical;clinical care;Collectins;comorbidity;cost;Cytochromes;Defensins;Disease;empowerment;Enzymes;Epithelial Cells;Epithelium;experience;extracellular vesicles;Functional disorder;Hepatocyte;Human;Impairment;In Vitro;in vivo;in vivo Model;Individual;Infection;inflammatory lung disease;Injury;Innate Immune System;Intervention;Knowledge;Lead;Literature;Liver;liver injury;Lung;lung development;Lung Diseases;Lung infections;lung injury;lung pathogen;lung repair;Macrophage;Malondialdehyde;Mediating;microbicide;military veteran;Modality;Modeling;Morbidity - disease rate;mortality;mouse model;Mucociliary Clearance;Mus;Older Population;Organoids;Pathogenesis;Phagocytosis;Pneumonia;Predisposing Factor;Predisposition;Preventive care;Production;Proteins;pulmonary function;Pulmonary Surfactant-Associated Protein D;Research;Research Personnel;response;Risk;Role;Sampling;Scientist;Severities;Smoke;Smoker;Smoking;Source;Streptococcus pneumoniae;Structure;surfactant;Testing;Time;Tissues;translational impact

PROJECT_TITLE: Reactive aldehydes and alcohol misuse in lung infections


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Digestive Diseases;Liver Disease;Organ Transplantation;Regenerative Medicine;Transplantation

ORG_CITY: MINNEAPOLIS

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Nearly one-third of deceased donor livers ultimately go unused due to the inability to preserve them long enough. We aim to develop a novel technology for indefinitely preserving whole livers in an extremely low-temperature vitrified (glass-like) state and subsequently using nanotechnology to rewarm them on demand. If successful, this novel technology will enable the banking, or “off-the-shelf” availability, of livers for transplantation and other vital biomedical applications such as cell therapy, biomedical research, and drug discovery.

PI_NAMEs: BISCHOF, JOHN C;FINGER, ERIK BRIAN (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Animals;Artificial Liver;Biocompatible Materials;Biological;Biomedical Research;Blood Vessels;Cell Therapy;Cellular Stress;Cessation of life;Chemicals;cold temperature;cryogenics;Cryopreservation;Cryoprotective Agents;Crystal Formation;Crystallization;Devices;disparity reduction;drug discovery;Drug toxicity;Emergency Situation;Family suidae;Frequencies;Functional disorder;Glass;Goals;Heart;Heating;Hepatic;Hepatocyte transplantation;Human;Ice;improved;In Vitro;in vivo;Industry;Injury;Investigation;iron oxide nanoparticle;Ischemia;Kidney;Liquid substance;Liver;liver preservation;liver transplantation;Lobe;Measures;Methods;nanoparticle;Nanotechnology;nanowarming;new technology;novel;Organ;organ allocation;Organ Preservation;Organ Size;Oryctolagus cuniculus;Osmosis;Pathway interactions;Patients;Performance;Perfusion;pharmacologic;Pharmacologic Substance;Phase Transition;post-transplant;Predisposition;Preparation;preservation;Preservation Technique;prevent;Procedures;Protocols documentation;radio frequency;Rattus;Recovery of Function;regenerative;Research;Resource Allocation;Resources;Rewarming;RF coil;scale up;Schedule;Science;Self-Help Devices;Solid;Specimen;Speed;Stress;success;System;Technology;Testing;Therapeutic;Therapeutic Research;Therapeutic Studies;thermal stress;Time;Toxic effect;Toxicity Tests;transplant model;Transplantation;Transplantation Surgery;Water

PROJECT_TITLE: Cryopreservation and nanowarming enables whole liver banking for transplantation, cell therapy and biomedical research

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Networking and Information Technology R&D (NITRD)

PI_NAMEs: KAPUR, TINA  (contact)

PROJECT_TERMS: 3-Dimensional;Academia;Adoption;Applications Grants;Artificial Intelligence;Biology;Biomedical Engineering;Businesses;cancer imaging;career;Clinical;Collaborations;Communication;Communities;Computer Assisted;computer science;Computer software;Data;Education;Educational Curriculum;Educational workshop;Encyclopedias;Engineering;Event;experience;Faculty;Funding;Goals;Government;Grant;hackathon;Hand;Home;Image;Image Analysis;image guided therapy;imaging facilities;imaging program;Industry;innovation;Institution;interest;International;Internet;Intervention;Investigation;Joints;Journals;K-Series Research Career Programs;Knowledge;Link;Magnetic Resonance;Medical Imaging;Medicine;meetings;Mentors;Mission;neuro-oncology;neuroimaging;next generation;North America;open source;Operative Surgical Procedures;outreach;Participant;Patient Care;Patients;Pattern;Physicians;Physics;program dissemination;programs;Publications;Publishing;Qualifying;quantitative imaging;Radiology Specialty;Research;Research Personnel;Resources;Science;Scientific Advances and Accomplishments;Scientist;Secure;Series;Site;Societies;software development;Standardization;success;Supervision;Technology;tool;Training;Training and Education;Training Programs;undergraduate student;United States National Academy of Sciences;United States National Institutes of Health;Visit;web site

PROJECT_TITLE: Training & Dissemination


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

ORG_CITY: ALBUQUERQUE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF NEW MEXICO

ORG_STATE: NM

PHR: PROJECT NARRATIVE Fetal Alcohol Spectrum Disorders are a set of major morphological, neurobiological, and cognitive abnormalities in offspring exposed to alcohol in utero. A common cognitive manifestation of alcohol exposure during neural development in humans, and in animal models of prenatal alcohol exposure, are deficits in spatial learning and memory. The primary objective of the present proposal is to identify the systems and neural circuit-level mechanisms involved in spatial learning and memory deficits after prenatal alcohol exposure by monitoring large ensembles of hippocampal neurons during active behavior and rest. Further investigation of the neurobiological mechanisms underlying spatial learning and memory impairments is critically important for the development of precise diagnostic tools and therapeutic interventions to help manage or reverse disordered brain states.

PI_NAMEs: CLARK, BENJAMIN J (contact)

PROGRAM_OFFICER_NAME: AKBAR, MOHAMMED

PROJECT_TERMS: Action Potentials;alcohol exposure;Animal Model;Animals;Behavior;behavioral phenotyping;Brain;Brain Diseases;Cells;Characteristics;Code;Cognitive;Coupled;dentate gyrus;Development;diagnostic tool;entorhinal cortex;Environment;Failure;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Generations;Goals;Hippocampal Formation;Hippocampus;Human;Immobilization;Impairment;in utero;in vivo;insight;Intervention;Investigation;Learning;Location;Memory;Memory impairment;Monitor;Morphology;Nervous System Physiology;neural;neural circuit;Neurobehavioral Manifestations;neurobiological mechanism;Neurobiology;neurodevelopment;Neurons;novel;offspring;patient population;Pattern;personalized diagnostics;Play;Population;Pre-Clinical Model;Process;programs;Rattus;Research;Rest;Role;Sleep;Spatial Behavior;spatial memory;spatial relationship;System;Testing;Therapeutic Intervention;Translating;Update

PROJECT_TITLE: Neural Basis of Spatial Memory Deficits After Prenatal Alcohol Exposure

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

PHR: Project Narrative Alcohol activates microglia within the central nervous system via the critical innate immune protein MyD88 , although it remains unclear if this activation is helpful or harmful for dependence and abuse. This project will determine the specific impact of chronic alcohol exposure in mice on microglial-MyD88 function and their impact on precise neuronal function and excess drinking behavior.

PI_NAMEs: BILBO, STACI D (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Ablation;Acute;addiction;adverse outcome;Alcohol consumption;alcohol exposure;alcohol response;alcohol use disorder;Alcohols;Astrocytes;Behavior;Brain;Brain Diseases;Buffers;cell type;Central Nervous System;chemokine;Chronic;chronic alcohol ingestion;comparison control;Complement;critical period;cytokine;Darkness;Data;Dependence;design;designer receptors exclusively activated by designer drugs;Development;Disease;drinking;drinking behavior;Electrophysiology (science);Exhibits;Extracellular Matrix;frontal lobe;Gene Expression Profile;Genetic;glial activation;Goals;Heavy Drinking;Immune;Impairment;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Inhibitory Synapse;Injections;innovation;Insula of Reil;Interneuron function;Interneurons;Knock-out;Link;Lipopolysaccharides;male;Measures;Mediating;Microglia;Morphology;mouse model;Mus;Myelogenous;Neuroimmune;neuroinflammation;Neuronal Plasticity;Neurons;neuropsychiatric disorder;novel;Oxidative Stress;Parvalbumins;pathogen;Pathology;Phagocytosis;Pharmaceutical Preparations;prevent;Production;Proteins;Protocols documentation;Regulation;Research Personnel;Resistance;response;Role;Signal Transduction;single-cell RNA sequencing;Sorting;Stimulus;Structure;Synapses;synaptic function;Testing;Toll-like receptors;Transgenic Organisms;Viral Vector;Western Blotting

PROJECT_TITLE: 5/11 Microglial MyD88 in Mouse Models of Excessive Alcohol Intake


NIH_SPENDING_CATS: Lung;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE An aberrant expansion stem-like cells is observed in a number of lung diseases, including chronic obstructive pulmonary disease (COPD), Cystic Fibrosis, and cancer. In this study we propose to use molecular and genetic approaches to define signals resulting from defects in airway epithelial architecture, which our observations suggest contribute to aberrant stem cell expansion and other disease phenotypes associated with lung diseases.

PI_NAMEs: VARELAS, XARALABOS  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Adult;Affect;Airway Disease;airway epithelium;Apical;Architecture;Basal Cell;Binding;Cell Culture Techniques;Cell Fate Control;cell growth;Cell Physiology;Cell Polarity;Cell Proliferation;Cells;Cellular biology;Chronic;Chronic Obstructive Pulmonary Disease;Complex;Cues;Cystic Fibrosis;Defect;defined contribution;Development;Developmental Process;Disease;disease phenotype;Dysplasia;EGFR gene;Epithelial Cells;Epithelium;exhaustion;Exhibits;Extracellular Matrix;Feedback;Functional disorder;Future;genetic approach;Genetic Transcription;Genome;Goals;Goblet Cells;Growth;Homeostasis;Human;in vivo;injury and repair;innovation;insight;Integral Membrane Protein;Integrins;Intercept;keratin 5;Knowledge;Laminin;Lung;Lung Diseases;lung injury;Malignant Neoplasms;Maps;Mediating;Mesenchymal;Methods;Molecular;Multipotent Stem Cells;Mus;Neuregulin 1;novel;Nuclear;Onset of illness;Organ;Pathology;Pathway interactions;Phenotype;Population;potential biomarker;Process;Proliferating;Pseudostratified Epithelium;Regenerative Medicine;regenerative therapy;repaired;Research;response;self-renewal;Signal Transduction;Specific qualifier value;stem cell differentiation;stem cell expansion;stem cell population;stem cells;stem-like cell;synergism;Testing;Therapeutic Intervention;therapeutic target;Trachea;transcription factor

PROJECT_TITLE: Defining epithelial polarity cues that direct cell fate

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: Project Narrative We have recently discovered that a subpopulation of Trypanosoma cruzi parasites (the cause of Chagas disease) is able to enter a metabolically inactive state that makes them resistant to anti-parasitic drugs. The goal of this project is to understand how this state of dormancy is generated and how existing drugs can be delivered, and new drugs discovered, so as to eventually clear these otherwise drug resistant forms from hosts.

PI_NAMEs: TARLETON, RICK L (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Acute;acute infection;Adverse effects;Animals;Antibiotic Therapy;Antiparasitic Agents;Benznidazole;Biology;Chagas Disease;Characteristics;Chronic;chronic infection;Combination Drug Therapy;Complex;cytotoxic;design;Detection;Development;drug discovery;drug efficacy;Drug resistance;Drug usage;effective therapy;environmental stressor;Exclusion;experimental study;Exposure to;Frequencies;Goals;Heart Diseases;Human;Image;Immune;Immune response;Immune system;Immunologics;Immunotherapy;improved;In Vitro;in vivo;Individual;Infection;Insecta;Investigation;Life;Light;Link;Location;Metabolic;microbial;Microscopy;Molecular;Monitor;novel;novel therapeutic intervention;novel therapeutics;Organ;Outcome;Parasites;Parasitology;Pathway interactions;Pattern;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Play;prevent;Process;Property;Regimen;Reporting;Research;Resistance;Risk;Role;small molecule;System;Therapeutic;therapeutic candidate;therapy design;Tissues;tool;transmission process;Treatment Efficacy;Treatment Failure;Treatment outcome;Treatment Protocols;Trypanocidal Agents;Trypanosoma cruzi;Work

PROJECT_TITLE: Trypanosoma cruzi dormancy and its implications for therapeutic treatment

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ORG_NAME: JOSLIN DIABETES CENTER

PHR: PROJECT NARRATIVE The incidence of type 2 diabetes continues to escalate worldwide, but fortunately, it is well established that regular physical activity can prevent or delay the onset of this disease. The long-term goal of this project is to understand the molecular mechanisms through which exercise improves glucose homeostasis and metabolic health, and in the last several years we have determined that when mothers exercise, their offspring have improved metabolic health. The specific focus of this research project for the next five years is to determine how maternal exercise has these remarkable beneficial effects on the health of offspring, which could provide a new paradigm for diabetes prevention and have a tremendous impact on health care worldwide.

PI_NAMEs: GOODYEAR, LAURIE J (contact)

PROGRAM_OFFICER_NAME: SILVA, CORINNE M

PROJECT_TERMS: Adipose tissue;Adult;Affect;Animals;Area;blood glucose regulation;Brown Fat;Cells;Clinical;clinical translation;combat;Consensus;Data;Destinations;Development;Diabetes prevention;Epigenetic Process;epigenetic regulation;Exercise;Exercise Physiology;Exercise Therapy;exercise training;experimental study;Female;Female of child bearing age;Fetal Liver;Fetal Tissues;Foundations;functional improvement;Funding;Generations;Genes;Genetic Transcription;glucose tolerance;glucose uptake;Goals;Health;Health Benefit;Healthcare;Hepatic Tissue;High Fat Diet;Homeostasis;improved;in vivo;Incidence;innovation;insulin sensitivity;Intervention;Investigation;Life Style;Literature;Liver;male;maternal obesity;Mediating;Mediator;Metabolic;Metabolic Diseases;Molecular;Mothers;Mus;Muscle;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;nutrition;Obesity;Obesity Epidemic;offspring;Onset of illness;Oocytes;optimal treatments;pharmacologic;Pharmacological Treatment;Phenotype;Physical activity;Physical Exercise;Placenta;Pregnancy;Pregnancy Proteins;pregnant;prevent;Prevention;protein function;Proteins;Protocols documentation;Publishing;reproductive;Research;Research Project Grants;Risk;Role;secretory protein;sedentary;Serum;Signal Transduction;Skeletal Muscle;skeletal tissue;sperm cell;Superoxide Dismutase;Tissues;tool;Training;transcriptome sequencing;transcriptomics;Transforming Growth Factor beta;transmission process;Vitamin D;Vitamin D3 Receptor;Woman;Work;World Health

PROJECT_TITLE: Exercise Regulation of Glucose Homeostasis

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Behavioral and Social Science;Chronic Pain;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Osteoarthritis;Pain Research;Physical Activity;Prevention;Primary Health Care;Rehabilitation;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: Lay Summary Knee osteoarthritis (OA) is a common, disabling problem in the United States. Walking can help treat and control pain from OA and walking in your neighborhood is a great way to exercise. This study will look at what characteristics of a neighborhood contribute to walking and how doctors should talk to their patients about it to help them accomplish their walking goals.

PI_NAMEs: GEBAUER, SARAH  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Adult;Affect;American;Area;Award;Big Data;big data management;built environment;career development;Caring;Characteristics;Chronic Disease;clinical care;cohort;Computerized Medical Record;cost;Country;Crime;Data;Data Set;Degenerative polyarthritis;design;Development Plans;Diagnosis;disability;Disabling;effective therapy;end stage disease;Epidemic;Epidemiology;evidence base;Exercise;exercise prescription;exercise program;experience;follow-up;Fright;Geographic Information Systems;Geographic Locations;Glean;Goals;Growth;Guidelines;Health;High Prevalence;human old age (65+);improved;Individual;Inequality;Information Sciences;Infrastructure;innovation;Intervention;Interview;Knee Osteoarthritis;knee replacement arthroplasty;Knowledge;Lead;Life;Link;Measures;Medical;Medical Records;Mentored Patient-Oriented Research Career Development Award;Mentorship;Methodology;Methods;metropolitan;Modeling;multilevel analysis;Musculoskeletal;neighborhood disadvantage;Neighborhoods;novel;Obesity;osteoarthritis pain;Outcome;Pain;Pain management;pain reduction;pain relief;pain score;pain symptom;Patient Care;patient engagement;Patients;Physical activity;Population;Prevalence;primary care provider;Provider;Public Health;public health intervention;Qualitative Methods;Reporting;Research;Resources;Retrospective cohort;Risk;Risk Factors;Sampling;sedentary lifestyle;Series;shared decision making;skills;social;social capital;Social Characteristics;Social Environment;social health determinants;Socioeconomic Status;software systems;statistics;Symptoms;Time;Training;United States;United States Department of Veterans Affairs;Urban Developments;Veterans;Veterans Health Administration;violent crime;walkability;Walking

PROJECT_TITLE: Neighborhood Barriers and Facilitators to Walking, the Epidemiology of Knee Osteoarthritis and Developing Effective Exercise Prescriptions

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative Recurrent, truncating driver mutations of PPM1D, the gene encoding the WIP1 protein phosphatase, occur across a range of human cancers, including Diffuse Midline Gliomas (DMG), a devastating brain tumor of childhood. We will evaluate the mechanisms through which PPM1D mutations drive tumor formation and will determine strategies to therapeutically target them. The results generated in this proposal will inform the development of precision medicine approaches for children with DMG, and will be relevant to thousands of other patients diagnosed with PPM1D-mutant tumors including leukemia and endometrial cancers.

PI_NAMEs: BANDOPADHAYAY, PRATITI  (contact)

PROJECT_TERMS: Affect;Apoptosis;Attenuated;attenuation;Biological Assay;Biological Models;Cell Cycle Arrest;Cell Cycle Checkpoint;Cells;CHEK1 gene;CHEK2 gene;Child;Childhood Brain Neoplasm;Childhood Glioma;clinically relevant;combinatorial;Coupling;CRISPR/Cas technology;curative treatments;Data;Dependence;Development;Diagnosis;diffuse midline glioma;DNA;DNA Damage;DNA damage checkpoint;DNA Repair Gene;driver mutation;Endometrial Carcinoma;Event;experimental study;FRAP1 gene;Genes;Genetic;genetic regulatory protein;genome-wide;Glioma;Gliomagenesis;Growth Factor;Histones;Human;Immunoprecipitation;In Vitro;in vivo;in vivo Model;Induced Mutation;inhibitor;insight;leukemia;Malignant Neoplasms;Mass Spectrum Analysis;MDM2 gene;Mitogen-Activated Protein Kinases;Modeling;mutant;Mutation;nerve stem cell;Oncogenes;Oncogenic;optimism;p38 Mitogen Activated Protein Kinase;Pathway interactions;patient population;Patients;Peptide Hydrolases;phosphoproteomics;PIK3CA gene;PPM1D gene;precision medicine;Process;Proliferating;protein degradation;Protein phosphatase;Proteins;Radiation;Recurrence;replication stress;Reporter;response;Role;Secondary to;Signal Pathway;Signal Transduction;stem cell model;Stress;Testing;Therapeutic;therapeutic target;TP53 gene;tumor;Ubiquitin;Variant;whole genome

PROJECT_TITLE: Targeting vulnerabilities of PPM1D-mutant gliomas

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE HIV/AIDS is a leading cause of morbidity and mortality worldwide, the overarching goal of this project is to explore the safety and therapeutic potential of a novel, combined cytokine treatment (IL-12 plus IL-15/IL-15ra) as a curative strategy for HIV/SIV in SIV-infected ART-treated, therapeutically vaccinated rhesus macaques. Specifically, we propose that the sequential administration of IL-12 and IL-15/IL-15ra will have a strong synergistic effect on antiviral responses leading to the reduction of SIV replication. If successful, this strategy will then be translated to the human clinic to achieve a cure for HIV infection without lifelong ART.

PI_NAMEs: AMARA, RAMA RAO ;VELU, VIJAYAKUMAR  (contact)

PROGRAM_OFFICER_NAME: SANDERS, BRIGITTE E

PROJECT_TERMS: Address;Adjuvant;Animal Euthanasia;Anti-viral Response;antiretroviral therapy;antiviral immunity;B-Lymphocytes;Blood;BLR1 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;chemokine receptor;Chronic;Clinic;Combined Modality Therapy;Complex;cytokine;cytokine therapy;cytotoxic;Data;Disease remission;DNA;DNA/MVA vaccine;Goals;Helper-Inducer T-Lymphocyte;HIV;HIV Infections;HIV/AIDS;Homing;Human;Immune;Immunity;Immunotherapeutic agent;improved;In Vitro;in vivo;Infection;Interferon Type II;Interleukin-12;Interleukin-15;Interleukin-2;Interruption;Knowledge;Lymphoid;Lymphoid Tissue;Macaca;Macaca mulatta;Modeling;Morbidity - disease rate;mortality;Natural Killer Cells;novel;novel therapeutics;Plasma;Production;Proliferating;response;restoration;RNA;Role;Safety;safety testing;secondary lymphoid organ;simian human immunodeficiency virus;SIV;SIV Vaccines;Structure of germinal center of lymph node;T cell response;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Tissues;TNF gene;TNFSF5 gene;Translating;Vaccinated;Vaccination;Vaccine Therapy;Viral;Viral reservoir;Viremia;Virus Replication;Work

PROJECT_TITLE: Combined cytokine therapy for sustained HIV remission


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: ROCHESTER

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Triple-negative breast cancer (TNBC) is an aggressive cancer subtype with limited treatment options. We have made the surprising discovery that the antioxidant glutathione (GSH) functions extracellularly, not intracellularly, to support TNBC growth. Our research will challenge the paradigm of antioxidant function in cancer by describing a novel mechanism of GSH function as a circulating source of amino acids and has the potential to reveal a completely new set of therapeutic targets for TNBC intervention.

PI_NAMEs: HARRIS, ISAAC SPENCER (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Ablation;Affect;Amino Acids;antioxidant therapy;Antioxidants;Breast Cancer Cell;breast tumorigenesis;cancer cell;Cancer Intervention;cancer subtypes;cancer therapy;Catabolism;Cells;Cellular Metabolic Process;Cysteine;cysteinylglycine;Cystine;Data;deprivation;Dipeptidases;Dipeptides;experimental study;extracellular;Gamma-glutamyl transferase;Gatekeeping;Genetic;Glutamates;Glutathione;Glycine;Goals;Growth;In Vitro;in vivo;Intercellular Fluid;interest;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mediating;mouse model;new therapeutic target;novel;Outcome;Perception;Plasma;Plasma Cells;Proteins;Research;Role;Source;Supplementation;Testing;Therapeutic;therapeutic target;Tissues;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor microenvironment;Tumor Promotion;tumorigenesis;Work

PROJECT_TITLE: Impact of extracellular glutathione catabolism on triple-negative breast cancer

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Hematology;Infectious Diseases;Sepsis

PHR: Project Narrative Polyphosphates are an understudied class of inorganic polymers, which are accumulated by bacteria as long linear chains of orthophosphate residues. Here, we hypothesize that bacterial polyphosphates interfere with a protective host immune response and mediate harmful outcomes of septic peritonitis after cecum ligation and puncture. The proposed studies aim for new insights into the pathogenesis of polyphosphate-dependent host-microbe interactions in the peritoneal/mucosal microenvironment and will help to better understand the systemic injury response to bacterial sepsis.

PI_NAMEs: BOSMANN, MARKUS  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Address;Affinity Chromatography;Agonist;Alpha Granule;arginase;Bacteremia;Bacteria;Bacterial Infections;bacterial metabolism;Binding Proteins;Biological;Blood coagulation;Blood Platelets;Bradykinin;cecal ligation puncture;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chemicals;chemokine;Coagulation Process;Colon;Complement Activation;cytokine;Data;Environment;Escherichia coli;Event;FDA approved;fighting;Future;Glycolysis;Gnotobiotic;Growth;Heterogeneity;Host Defense;host-microbe interactions;Human;Immune;Immune response;Immunity;improved;Incubated;Infection;Inflammation;inflammatory milieu;inorganic phosphate;insight;Integration Host Factors;Intervention;Intestinal Mucosa;Invaded;Knowledge;Label;Length;Light;Link;Macrophage;Mammalian Cell;mast cell;Measures;Mediating;Metabolic;Metabolism;Modeling;Molecular;Molecular Chaperones;monocyte;Mononuclear;Morbidity - disease rate;mortality;Mucous Membrane;Mus;mutant;Natural Immunity;neutrophil;novel;Nutrient;Organism;Orthophosphate;Outcome;pathogen;Pathogenesis;Patients;Peritoneal;Peritoneal Sepsis;Phagocytes;Pharmaceutical Preparations;Phenotype;Polymers;polymicrobial sepsis;Polyphosphate kinase;Polyphosphates;Prevention;Production;Proteins;proteogenomics;Proteomics;Reaction;Recombinants;recruit;Reporting;Research;Research Project Grants;response;response to injury;Role;Saccharomyces cerevisiae;Sampling;Sepsis;Severities;Shapes;Signal Pathway;Signal Transduction;Source;Sterility;Stress;Surrogate Endpoint;Testing;Therapeutic;Titrations;TLR4 gene;transcriptome;Work

PROJECT_TITLE: Bacterial polyphosphates in sepsis


NIH_SPENDING_CATS: Aging;Women's Health Research

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative  The osteocyte is the most abundant cell in mature bone and functions to sense mechanical stress and regulate bone homeostasis. We have found that the Fibroblast Growth Factor signaling pathway is required for osteocyte viability in adult bone. Understanding the underlying biological mechanisms connecting Fibroblast Growth Factor signaling to osteocyte viability and skeletal homeostasis will lead to the identification of new genes and pathways that could be targeted to promote osteocyte viability and maintain healthy bone.

PI_NAMEs: ORNITZ, DAVID M (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Address;Adolescent;Adult;Adverse effects;Affect;Age;age related;age related decline;aged;Aging;Anoikis;Antineoplastic Agents;Apoptotic;Autophagocytosis;Biological;Biology;Biomechanics;bone;bone health;bone mass;bone quality;Bone remodeling;bone strength;Bypass;cancer therapy;Cell Death;Cell Line;Cells;Cessation of life;Clinical;clinically relevant;conditional knockout;cost;Data;Degenerative polyarthritis;Deterioration;Development;Disease;Endogenous Factors;Etiology;experimental study;FDA approved;FGFR1 gene;Fibroblast Growth Factor;Fibroblast Growth Factor Receptors;Follow-Up Studies;Fracture;Genes;genetic approach;Glucocorticoids;Gonadal Steroid Hormones;Histologic;Homeostasis;hormone deficiency;Impairment;In Vitro;in vivo;in vivo evaluation;Inflammation;inhibitor;Knowledge;loss of function;Maintenance;Malignant Neoplasms;Mature Bone;Mechanical Stress;Modeling;Molecular;Morbidity - disease rate;mouse model;Mus;novel;old mice;Osteoblasts;Osteocytes;Osteogenesis;Ovariectomy;Pathway interactions;pharmacologic;Physiology;Postmenopausal Osteoporosis;pre-clinical;Property;Publications;Publishing;Receptor Inhibition;Receptor Signaling;Regulation;Role;Secondary to;Signal Pathway;Signal Transduction;skeletal;System;Testing;Therapeutic;treatment duration

PROJECT_TITLE: Regulation of Osteocyte Survival by Fibroblast Growth Factor Signaling Pathways

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_NAME: JACKSON LABORATORY

PHR: PROJECT NARRATIVE The oncogene MYC is one of the most commonly altered genes in human cancer, yet there are no FDA-approved MYC-targeting therapies due to a lack of a binding site for standard chemical inhibitors; therefore, it is imperative to develop alternative methods to treat MYC-driven tumors. Recent evidence indicates that the tumor-promoting activity of MYC requires RNA splicing, a process that determines which version of a gene is expressed within cells. In this research, we will identify which proteins controlling RNA splicing and gene versions are impacted by MYC to promote cancer, and we will thereby discover targets for the development of novel therapeutic strategies targeting RNA splicing in tumors and new markers that could be used for clinical diagnosis.

PI_NAMEs: ANCZUKOW-CAMARDA, OLGA  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: 3-Dimensional;Address;Alternative Splicing;Apoptosis;Automobile Driving;Binding;Binding Sites;Biological Assay;Breast;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Model;Breast Epithelial Cells;Cancer Biology;cancer cell;Cancer Cell Growth;Cancer Patient;cell growth;Cell Line;Cell model;Cell Proliferation;Cells;chemical standard;Clinical;clinical biomarkers;clinical diagnosis;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Data;Data Set;Development;Diagnostic Neoplasm Staging;Distant Metastasis;DNA;Dropout;Excision;Exons;Failure;FDA approved;functional genomics;Gene Expression Regulation;Genes;Genetic Transcription;Genomic approach;Goals;Growth;Human;Image;In Vitro;in vivo;Individual;inhibitor;insight;Invaded;knock-down;Knowledge;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mammary Neoplasms;Methods;migration;Molecular;MYC gene;neoantigens;Neoplasm Metastasis;novel;novel marker;novel strategies;novel therapeutic intervention;Oncogenic;Oncoproteins;Organoids;Outcome;overexpression;Pathogenesis;patient prognosis;Patient-Focused Outcomes;predictive signature;predictive tools;Primary Neoplasm;Process;Protein Isoforms;Proteins;Proteomics;Proto-Oncogene Proteins c-myc;public database;RAS genes;Regulation;Research;Resistance;RNA;RNA Splicing;RNA-Binding Proteins;Signal Transduction;targeted treatment;Testing;The Cancer Genome Atlas;therapeutic development;Therapeutic Studies;therapeutic target;Time;Tissues;tool;Transcript;transcription factor;transcriptome sequencing;triple-negative invasive breast carcinoma;tumor;tumor growth;Tumor Markers;Tumor Promotion;Tumor Suppressor Proteins;tumorigenesis;tumorigenic

PROJECT_TITLE: MYC-regulated RNA Binding Protein Networks and Spliced Isoforms Driving Cancer

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Physical Activity;Prevention

ORG_CITY: CHAPEL HILL

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative The accurate assessment of digital media use in children is essential for the development of evidence-based screen use guidelines. We aim to validate wearable light sensors using advanced analytics and data processing in both laboratory and naturalistic settings, thus providing an objective, scalable method to assess children’s screen media use.

PI_NAMEs: WILLIS, ERIK A (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: Accelerometer;Adult;advanced analytics;Algorithms;Behavior;body position;Books;Calibration;Caregivers;Cellular Phone;Characteristics;Child;Child Health;Child Welfare;Classification;classification algorithm;Clip;Code;Color;computerized data processing;Computers;cost effective measures;Data;Data Collection;Detection;Development;Devices;digital media;Disease;Dose;Effectiveness;Electronics;Environment;Error Sources;evidence base;evidence based guidelines;Eyeglasses;Family;Glass;Guidelines;Health;Health behavior;Household;Hybrids;innovation;instrument;Intervention;Knowledge;Laboratories;Learning;Life Style;Light;Location;machine learning algorithm;machine learning method;Measurement;Measures;media use;member;Methods;Modeling;Monitor;Movement;novel;Obesity;open source;Outcome;Parents;Patient Self-Report;Physical activity;Play;poor sleep;Predisposition;Prevalence;prevent;Protocols documentation;Qualifying;Randomized;Reading;Research;Research Personnel;response;Risk;Risk Factors;Risk Management;sedentary;sedentary lifestyle;sensor;Sleep;sleep quality;social contact;standard measure;Structure;Tablets;Techniques;temporal measurement;Testing;Time;tool;Training;tv watching;Validation;Validity and Reliability;Video Recording;wearable data;wearable device;wearable sensor technology;Work

PROJECT_TITLE: Novel wearable sensor calibration and validation for automated measurement of screen time in children

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Cardiovascular;Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Lung

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Current therapy for chronic obstructive pulmonary disease (COPD), which is the fourth leading cause of death in the United States, focuses on inhaled medications without targeting systemic processes although COPD is now recognized as a disease with systemic manifestations. Understanding whether platelet activation, which perpetuates inflammation, regulates immune cell function, and has long been implicated in the development and rupture of atherosclerotic plaques, is associated with respiratory morbidity may uncover a target for systemic therapy in COPD. A potential antiplatelet therapy, aspirin, is no longer recommended as primary prevention for cardiovascular disease, thus a clinical trial to determine an effective aspirin dose that suppresses platelet activation in COPD is timely and provides preliminary data for a larger trial investigating whether aspirin improves respiratory morbidity in COPD that may identify an alternative indication.

PI_NAMEs: FAWZY, ASHRAF  (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Acute;Adenosine Diphosphate;Adrenal Cortex Hormones;Agonist;Algorithms;Arachidonic Acids;Aspirin;atherosclerotic plaque rupture;Biological Markers;Biology;Blood Platelets;Bronchodilator Agents;Cardiovascular Diseases;cardiovascular disorder prevention;Cardiovascular system;career;career development;Cause of Death;Cell Physiology;Cells;Chronic Obstructive Pulmonary Disease;circulating biomarkers;Clinical Trials;Clinical Trials Design;cohort;Collagen;comorbidity;coronary artery calcification;Cross-Over Studies;Data;design;Development;Development Plans;diabetic;digital repositories;Disease;Disease Outcome;Dose;Double-Blind Method;Emergency department visit;Endothelium;epidemiology study;Event;experience;follow-up;former smoker;Future;Goals;Hospitalization;Immune;improved;In Vitro;in vivo;Incidence;Individual;individualized medicine;Inflammation;Infrastructure;Inhalation;Inhalators;Laboratories;Leukocyte Trafficking;Leukocytes;Link;Measures;Membrane;Mentorship;Methodology;monocyte;Morbidity - disease rate;mortality;neutrophil;novel;novel therapeutics;Observational Study;Outcome;Participant;Pathway interactions;Patients;Pharmaceutical Preparations;Platelet Activation;Platelet Count measurement;Population;precision medicine;Predisposition;Primary Prevention;Procedures;Process;prospective;Proteins;pulmonary function;Quality of life;Randomized;randomized trial;Randomized, Controlled Trials;receptor;Recommendation;recruit;respiratory;Respiratory Disease;respiratory morbidity;Respiratory Signs and Symptoms;response;Role;Sampling;Scanning;Selection Bias;SELP gene;Serotonin;Severity of illness;skills;Smoker;Surrogate Markers;Symptoms;systemic inflammatory response;Systemic Therapy;Telephone;Thromboxane B2;Thromboxanes;TNFSF5 gene;trafficking;Training;Translational Research;translational scientist;United States;urinary;Work;X-Ray Computed Tomography

PROJECT_TITLE: Platelet Activation Pathways and Respiratory Morbidity in COPD

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Asthma;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative This is an efficacy-implementation trial comparing brief shared decision-making to a dose-matched attention control. Interventions are integrated into office visits with patients' providers delivering the intervention to 200 black adults with asthma; patients are followed for 12-months.

PI_NAMEs: GEORGE, MAUREEN  (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adoption;Adrenal Cortex Hormones;Adult;Affect;Aftercare;Asthma;asthma exacerbation;attentional control;Belief;Black Populations;Black race;brief intervention;Caring;Centers for Population Health;Cessation of life;Child;Chronic Disease;Client;Clinic Visits;Clinical;clinical application;clinical efficacy;clinical implementation;Clinical Management;clinical practice;Clinical Trials;Communities;community intervention;Consolidated Framework for Implementation Research;Couples;Data;Death Rate;design;Dimensions;Disease;Disparity;disparity reduction;Dose;effective therapy;efficacy testing;efficacy/implementation trial;Enrollment;Ethnic Origin;experience;Federally Qualified Health Center;Foundations;General Population;Goals;health disparity;health disparity populations;Hispanic;Hospitalization;implementation study;improved;Inhalation;Intervention;Knowledge;loved ones;Low income;Measures;Medicine;Methods;New Jersey;New York City;Office Visits;Outcome;Participant;patient engagement;Patients;pilot trial;Population;post intervention;Poverty;Prevalence;prevent;primary care provider;primary care setting;primary outcome;process evaluation;Protocols documentation;Provider;Public Health;Quality of life;Questionnaires;Race;Randomized;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;reduce symptoms;Research;secondary outcome;Self Management;shared decision making;Shortness of Breath;Standardization;Symptoms;Time;Training;Treatment Efficacy;trial comparing;Underinsured;Uninsured;Visit;Wheezing

PROJECT_TITLE: BREATHE: An efficacy-implementation trial of a brief shared decision making intervention among Black adults with uncontrolled Asthma in Federally Qualified Health Centers (FQHC).

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Hypertension prevalence increases with aging and is an important modifiable risk factor for Alzheimer’s disease and related dementias and cardiovascular disease. The overall goals of this K24 program are to investigate the mechanisms (including social determinants of health) of the use, underuse, and unsafe use of antihypertensive medications to prevent aging-related multimorbidity, including Alzheimer’s disease and related dementias and cardiovascular disease, as well as to train the next generation of diverse, patient-oriented, aging-related research scientists in hypertension pharmacoepidemiology. This proposal will have a significant public health impact because it will (1) increase the number of new patient- oriented researchers from diverse backgrounds dedicated to optimizing medication use to prevent aging- related multimorbidity and (2) generate new knowledge on the mechanisms leading to the underuse, misuse, and unsafe use of antihypertensive medications to reduce aging-related multimorbidity across the US population.

PI_NAMEs: BRESS, ADAM P (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Accountability;Age;Aging;aging related;Alzheimer's disease related dementia;Alzheimer's disease risk;Angiotensin II Receptor;Angiotensin-Converting Enzyme Inhibitors;Anti-Hypertensive Agents;Area;Award;Biometry;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure intervention;Brain;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular risk factor;career;Career Choice;career development;Cognitive;cognitive function;Color;Communities;Competence;Data;Dedications;design;Development Plans;Diabetes Mellitus;Educational Curriculum;Educational workshop;Ensure;Environment;Evaluation;experience;frailty;Funding;Future;Geriatrics;Goals;Happiness;health equity;Health Insurance;Health Personnel;Hypertension;improved;Individual;Infrastructure;Institution;Intervention;Intervention Trial;Investments;Knowledge;Learning;Lesion;Manuscripts;Mentors;Mentorship;Midcareer Investigator Award in Patient-Oriented Research;modifiable risk;Morbidity - disease rate;mortality;multiple chronic conditions;Needs Assessment;next generation;Outcome;patient oriented;patient oriented research;Patients;peer coaching;personalized approach;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;Pharmacy facility;Population;population health;Positioning Attribute;Prevalence;prevent;Principal Investigator;Process;Productivity;programs;Public Health;Reasons for Geographic And Racial Differences in Stroke;Regimen;Research;Research Personnel;Research Project Grants;Resources;Risk Factors;Risk Reduction;Role;Scientist;Services;skill acquisition;skills;social health determinants;Structure;success;synergism;Techniques;Testing;Time;Training;training opportunity;Training Programs;Underrepresented Populations;Universities;Update;Utah;white matter;Woman;Work;Writing

PROJECT_TITLE: Using pharmacoepidemiology to optimize antihypertensive medication use to prevent aging-related multimorbidity: Midcareer investigator award in patient-oriented research and mentoring.

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Immunotherapy;Neurodegenerative;Neurosciences

ORG_CITY: IOWA CITY

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project narrative: Many glaucoma patients experience continued vision loss despite maximally reduced intraocular pressure, indicating that additional factors contribute to the pathology of the disease. Our preliminary studies have indicated that the T-cell population of some patients exhibits a markedly pro-inflammatory skew and that the removal of T-cells protects vision in animal models of the disease. The goal of this project is to identify which T-cell population is active in this process and to elucidate the mechanisms of T-cell mediated damage to the retina in glaucoma.

PI_NAMEs: KUEHN, MARKUS H. (contact)

PROGRAM_OFFICER_NAME: HENLE, STEVEN JOHN

PROJECT_TERMS: Affect;Age;Alleles;Animal Disease Models;Animal Model;Animals;axonal degeneration;B-Lymphocytes;Biological Assay;Blindness;Blood specimen;CD3 Antigens;CD4 Positive T Lymphocytes;Cell Death;Cell Fraction;cell injury;cell mediated immune response;cell type;Cessation of life;Chronic;Clinical Research;comparison control;Cytoprotection;cytotoxic;Data;design;Development;Disease;Excision;Exhibits;expectation;experience;Extravasation;Eye;Eye diseases;Frequencies;Functional disorder;Future;Gene Deletion;Gene Expression Profile;Genetic Transcription;Glaucoma;Goals;Human;human disease;Immune response;Immunohistochemistry;immunomodulatory therapies;immunoregulation;improved;in vitro Assay;in vivo;Individual;Inflammation;Inflammatory;innovation;insight;Knock-out;Knockout Mice;lymph nodes;Mature T-Lymphocyte;Mediating;Medical;Methods;Modeling;Molecular;mouse model;Mus;myocilin;normotensive;novel;novel therapeutic intervention;Pathology;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;Persons;Physiologic Intraocular Pressure;Population;preservation;Primary Open Angle Glaucoma;Process;Production;Publishing;Quality of life;Retina;retinal damage;Retinal Ganglion Cells;Rodent Model;Role;single nucleus RNA-sequencing;T cell therapy;T-Lymphocyte;Testing;Therapeutic;Time;TNF gene;Transgenic Mice;translational impact;Treatment Protocols;Vision;Work

PROJECT_TITLE: T-cell mediated RGC damage in glaucoma

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: AMES

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: IOWA STATE UNIVERSITY

PHR: Relevance Antibiotic resistant Campylobacter is a serious antibiotic resistance threat to public health. This project will elucidate a new mechanism used by Campylobacter for multidrug resistance and for coping with selection pressure from use of various antibiotics. The findings will facilitate the development of intervention strategies to control the emergence and spread of antibiotic resistance in this significant human pathogen.

PI_NAMEs: YU, EDWARD W;ZHANG, QIJING  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Affect;Amino Acids;Animal Model;Animals;antibiotic efflux;Antibiotic Resistance;Antibiotics;antimicrobial;bacterial fitness;Bile fluid;Binding;Biological Models;Campylobacter;Campylobacter infection;Campylobacter jejuni;Carbapenems;Centers for Disease Control and Prevention (U.S.);Chimeric Proteins;Clinical;Clinical Treatment;clinically relevant;co-infection;Coculture Techniques;Colistin;conformational conversion;coping;CRISPR/Cas technology;Crystallization;Culture Media;Data;Databases;Development;Diarrhea;Drug Efflux;Drug-resistant Campylobacter;efflux pump;enteric pathogen;experimental study;fitness;fluoroquinolone resistance;Genes;Genetic;Genetic Polymorphism;genome sequencing;Goals;gut colonization;Homologous Gene;Human;human pathogen;Image;In Vitro;in vivo;Individual;insight;Intervention;Intestines;Ion Channel;Knowledge;Ligands;Maps;Mediating;Membrane;Membrane Fusion;Membrane Transport Proteins;Multi-Drug Resistance;Mutation;novel;Pathogen detection;pathogenic bacteria;periplasm;Pharmaceutical Preparations;Physiology;Play;Positioning Attribute;pressure;Prevalence;Proteins;Protomer;Public Health;Pump;Research Personnel;Resistance;resistance mechanism;single-molecule FRET;Solid;Structure;Structure-Activity Relationship;System;Techniques;therapy development;transmission process;Treatment Failure;Variant;whole genome;Work;World Health Organization;X-Ray Crystallography

PROJECT_TITLE: Emerging multidrug resistance mechanisms in Campylobacter

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-S(02)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: AUSTIN

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: PROJECT NARRATIVE Excessive alcohol consumption is a major public health hazard. This component of the Integrative Neuroscience Initiative on Alcoholism-Neuroimmune consortium is a research project that will examine neuroimmune activity in the nucleus accumbens, a brain region that mediates the reinforcing effects of alcohol. The results of this project will shed new light on how interactions between neurons and non-neuronal brain cells promote excessive alcohol consumption.

PI_NAMEs: MANGIERI, REGINA A. (contact)

PROJECT_TERMS: Acute;Alcohol consumption;alcohol effect;alcohol response;Alcohol withdrawal syndrome;Alcoholism;Alcohols;Animals;Astrocytes;Behavior;Behavioral Model;Brain;brain cell;brain health;Brain region;cell type;Cells;Chronic;Collaborations;cytokine;Development;Dopamine D1 Receptor;drinking;drinking behavior;Electrophysiology (science);Ethanol;Ethanol dependence;Exhibits;experience;functional adaptation;Funding;Genetically Engineered Mouse;glial activation;Glutamates;Goals;Health Hazards;Heavy Drinking;Induced Neurons;innovation;insight;Intake;Interleukins;Knowledge;Link;MALAT1 gene;Mediating;Membrane;Microglia;Mission;Molecular;Molecular Analysis;Mus;National Institute on Alcohol Abuse and Alcoholism;Neuroglia;Neuroimmune;neuronal excitability;Neurons;Neurosciences;neurotransmission;Nucleus Accumbens;Output;Pathway interactions;Phenotype;Physiology;Play;Productivity;Public Health;receptor;Recording of previous events;Research Personnel;Research Project Grants;Resources;Rewards;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Slice;Structure;Synapses;synaptic function;Testing;Time;transmission process;Untranslated RNA;Work

PROJECT_TITLE: 9/11 Neuroimmunophysiology of excessive alcohol intake


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: HAT YAI  SONGKLA

ORG_COUNTRY: THAILAND

ORG_FIPS: TH

ORG_NAME: PRINCE OF SONGKLA UNIVERSITY

PHR: PROJECT NARRATIVE Within the tuberculosis (TB) endemic areas in Southeast Asia, Prince of Songkla University and Mahidol University, Thailand and Methodist Hospital, Houston, Texas, will provide a degree- granting and research training program related to the epidemiology of TB, to build research and disease control capacity in Myanmar, Indonesia, and Thailand. The Fogarty International Center's support will allow the regional network of institutes to strengthen their capacity, especially on human resources for research. After five years of the program, there will be altogether 56 researchers from these three countries trained at Doctoral, Master, and short- course level.

PI_NAMEs: CHAIPRASERT, ANGKANA ;CHONGSUVIVATWONG, VIRASAKDI  (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Applications Grants;Biometry;career development;Collaborations;Community Health;Data Analyses;Data Collection;Data Reporting;Doctor of Philosophy;Educational Curriculum;Educational workshop;Ensure;Epidemiology;Faculty;Funding;Home;Hospitals;Human Resources;Income;Indonesia;International;Laboratories;low and middle-income countries;Medical;Medical Research;Microbiology;Multidrug-Resistant Tuberculosis;Myanmar;Phase;programs;Public Health;Research;Research Methodology;Research Personnel;Research Proposals;Research Training;responsible research conduct;Running;Science;Southeastern Asia;Sumatra;Thailand;Training;Training Programs;Universities;Writing

PROJECT_TITLE: TB/MDR-TB Research training and Capacity Strengthening for LMIC in Southeast Asia Phase II

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-Z(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Services;Palliative Care

ORG_CITY: NEW YORK

ORG_DEPT: ANESTHESIOLOGY

PHR: Project Narrative Over 600,000 people die from cancer each year in the United States and many more suffer from other serious illnesses that may benefit from specialist palliative care. By identifying modifiable factors that influence effectiveness of specialist palliative care delivery, this project will directly inform policies for palliative care programs, cancer centers and hospitals to enable and ensure the delivery of effective palliative care for all patients with cancer.

PI_NAMEs: HUA, MAY  (contact)

PROGRAM_OFFICER_NAME: MOLLICA, MICHELLE A

PROJECT_TERMS: acute care;Advanced Malignant Neoplasm;Affect;American Society of Clinical Oncology;cancer care;Cancer Center;Cancer Hospital;care delivery;care systems;Caring;Certification;Characteristics;chemotherapy;Clinical;cohort;Collection;Consultations;cost;Data;Data Set;Data Sources;Decision Making;Disseminated Malignant Neoplasm;Effectiveness;Electronics;end of life;end of life care;Enrollment;Ensure;future implementation;Goals;Growth;Guidelines;health care service utilization;Heterogeneity;hospice utilization;hospital care;hospital readmission;Hospitals;improved;improved outcome;informant;insight;Institution;Intensive Care Units;Interview;Knowledge;Length;Life;Link;Malignant Neoplasms;Measures;Mediation;Medicare claim;Modeling;Morphologic artifacts;National Cancer Institute;novel;Outcome;Outpatients;Palliative Care;Pathway interactions;Patient Care;Patient-Focused Outcomes;Patients;Persons;Physician Data Query;Policies;Population;preference;programs;Protocols documentation;Provider;Psychosocial Assessment and Care;Qualitative Research;Quality of Care;Quality of life;Race;Recommendation;Registries;Research;Research Methodology;Role;Site;Site Visit;Specialist;symptom management;symptomatology;Targeted Research;Time;United States;Visit;Work;Writing

PROJECT_TITLE: Determinants of Palliative Care Effectiveness for Patients with Metastatic Cancer

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


ORG_CITY: INDIANAPOLIS

ORG_NAME: RLR VA MEDICAL CENTER

PHR: US veterans develop diabetes and chronic kidney disease (CKD) at an alarming rate, and comorbidity is twice as common in veterans compared with the general population. Both diseases put patients at increased risk of fracture and when fractures occur, patients are at a greater risk of death compared to other populations. Treatments for skeletal disease typically address deficits in either bone mass or tissue quality, which may be insufficient in cases of combined CKD and diabetes where there are known deficits in both. Unfortunately, models needed to study treatment of these comorbid conditions are lacking. The goal of this project is to study skeletal interactions between diabetes and CKD and to identify effective combination skeletal treatments. Specifically, we propose experiments to study combined treatments for bone mass and tissue quality deficiencies, in the context of disease onset age and duration. The results of this work will provide alternative ways to prevent or treat skeletal deficits associated with diabetes and CKD in our veteran population.

PI_NAMEs: WALLACE, JOSEPH MICHAEL (contact)

PROJECT_TERMS: Address;Adenine;Age;Age of Onset;aged;Animal Disease Models;Animal Model;Biochemical;Biochemical Markers;Biochemistry;Biology;bone;Bone Diseases;bone mass;bone quality;Bone Tissue;Cells;Chronic;Chronic Kidney Failure;Clinical;Collagen;Combined Modality Therapy;comorbidity;comparison intervention;Complex;Coupled;Data;Defect;Diabetes Mellitus;Disease;disease model;Estrogens;Exclusion;Exhibits;experimental study;FDA approved;Fracture;fracture risk;General Population;glucose monitor;Glucose tolerance test;Glycosylated hemoglobin A;Goals;Histology;Hydration status;illness length;improved;in vivo;Individual;Insulin;Insulin Resistance;Intervention;Kidney;Late Effects;Measures;mechanical load;mechanical properties;Mechanics;military veteran;Minerals;Modeling;Molecular;mortality;mortality risk;mouse model;Multiscale Mechanics;Mus;Musculoskeletal;nanoindentation;novel;old mice;Onset of illness;Osteogenesis;Outcome;Patients;Persons;Pharmaceutical Preparations;Pharmacologic Substance;physical property;Population;Prevalence;prevent;Property;Raloxifene;Raman Spectrum Analysis;Resistance;Resistance development;Risk;Severity of illness;sex;skeletal;skeletal disorder;Skeleton;Streptozocin;structural imaging;Structure of beta Cell of islet;Sum;Testing;Therapeutic;Tissues;Translating;Treatment Protocols;United States;Veterans;Work

PROJECT_TITLE: Improving bone mass and quality in comorbid diabetes and chronic kidney disease


ORG_NAME: OMAHA VA  MEDICAL CENTER

PHR: This proposal addresses how the lungs of older people change with age. In particular, we will study how mucin 5AC increases in the airway epithelium with age, how that relates to increased susceptibility to lung cancer and how we can diminish mucin 5AC levels in the lung. This is of importance to Veterans as lung cancer is one of the three most diagnosed cancers in the VA system, while 48% of the Veterans enrolled in the VA are over the age of 65.

PI_NAMEs: BAILEY, KRISTINA L (contact)

PROJECT_TERMS: Accounting;Acetylation;Address;Age;age related changes;aged;Aging;aging mechanism;aging process;aging related;airway epithelium;cancer diagnosis;Cancer Etiology;Cancer Patient;carcinogenesis;carcinogenicity;cell age;Cells;Cellular Stress;Cessation of life;Chronic Obstructive Pulmonary Disease;cigarette smoking;Data;Deacetylation;Development;DNA Damage;Enrollment;Environment;Epithelial Cells;human old age (65+);idiopathic pulmonary fibrosis;K-ras mouse model;Knockout Mice;Link;Lung;lung carcinogenesis;lung development;Lung Diseases;Malignant neoplasm of lung;Malignant Neoplasms;MAPK1 gene;Mitogen-Activated Protein Kinases;Modeling;mouse model;Mucins;multidisciplinary;Mus;Older Population;Oxidative Stress;Oxidative Stress Induction;Patients;phosphatase-1 kinase;Play;Predisposition;Production;Rejuvenation;Research Personnel;Resveratrol;Risk;Risk Factors;Role;SIRT1 gene;System;tumor;tumorigenesis;United States;Up-Regulation;Urethane;Veterans

PROJECT_TITLE: Pulmonary aging increases MUC5AC in the airway epithelium, increasing the risk of carcinogenesis