ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

ORG_CITY: SILVER SPRING

ORG_NAME: NATIONAL MEDICAL ASSOCIATION

PHR: Project Narrative Approximately 1.5% of the practicing ophthalmologist in the US are under-represented minorities. Increasing the number of minority practitioners would improve access to eye care in underserved communities as these physicians are more likely to practice in these communities than majority physicians. Recruiting more under-represented minority medical students to the field of ophthalmology and supporting these already in residency programs will help decrease health disparities in the US.

PI_NAMEs: MILLER, EYDIE G;OLIVIER, MILDRED MARIE GERARD (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Academia;Academy;African American;American;American Medical Association;Appointment;Awareness;Black Populations;career;Caring;Clinical;Communication;Communities;Development;Educational process of instructing;Exposure to;Eye;Eye diseases;Fellowship;Funding;Goals;Improve Access;instructor;Interview;Medical;medical schools;medical specialties;Medical Students;Medicine;meetings;member;Mentors;Mentorship;Minority;Minority Groups;Names;National Eye Institute;Ophthalmologist;Ophthalmology;Paper;Participant;Pathway interactions;Patient Recruitments;peer;Physicians;posters;Privatization;Process;programs;recruit;Reduce health disparities;Research;Research Personnel;Residencies;role model;Seasons;segregation;Series;skills;skills training;Specialist;Students;Training;Training Programs;Underrepresented Minority;underserved community;Voice;Work

PROJECT_TITLE: Minority Pipeline Program in Ophthalmology Rabb-Venable in Excellence in Research in Conjunction with the Ophthalmology Section National Medical Association


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Newark

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Narrative This application seeks funding for an Initiative for Maximizing Student Diversity Award to support the recruitment and training of predoctoral students from diverse backgrounds with the overall goal of increasing the pool of PhDs from under-represented minorities who engage successfully in biomedical research and research-related careers. Our program structure and activities are designed to bring together and train under-represented predoctoral students - including IMSD trainees and non- trainees - from across the biological/biomedical graduate programs on the flagship Rutgers-New Brunswick campus. Our training program adds IMSD-specific program elements to existing institutional and graduate program-specific initiatives in order to enhance student success and performance and at the same time improve career preparation and outcomes.

PI_NAMEs: MILLONIG, JAMES H.;RUNNELS, LOREN W (contact);SCOTT, TRACY E

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: New Brunswick

PROJECT_TITLE: IMSD at Rutgers - New Brunswick

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: BOSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: OVERALL – PROJECT NARRATIVE The Multicenter Osteoarthritis (MOST) Study has been a major source of new knowledge about the course of OA and factors that affect it, having published over 180 articles providing insights into OA causes and consequences, and serving as the basis for 31 career development awards to date. We will use an integrated approach in the next cycle of MOST (MOST4) overseen by an Administrative Core, involving a Clinical Data Collection and Management Core, Analysis Core, and Imaging Core, to efficiently address key knowledge gaps through the conduct of three Projects that will examine impairments in response to exercise in knee OA, and its risk factors and consequences; synovial fluid proteomics to gain insights into localized versus generalized OA phenotypes; and the relation of intra-articular mineralization and of different crystal types to knee pain, inflammation, and OA structural pathology. This work will produce new actionable insights regarding pain, structural deterioration and function loss in knee OA.

PI_NAMEs: FELSON, DAVID TOBIN (contact);NEOGI, TUHINA

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Address;advanced disease;Adverse effects;Affect;Bathing;Biological Markers;Biology;Biomechanics;blood-based biomarker;Calcium;career;career development;Chronic;Clinical;Clinical Data;Clinical Trials;Clinical Trials Data Monitoring Committees;cohort;community advisory board;Complex;Crystal Formation;Data;Data Collection;data management;Degenerative polyarthritis;Deposition;Deterioration;Diagnostic;disabling disease;Disease;Disease Progression;disorder prevention;effective therapy;Eligibility Determination;Enrollment;Exercise;experience;falls;Fright;functional decline;functional outcomes;Glues;Goals;Grant;Heterogeneity;Image;Impairment;individualized prevention;Inflammation;Inflammatory;insight;interdisciplinary approach;Investigation;Joints;K-Series Research Career Programs;Knee;Knee Osteoarthritis;knee pain;Knowledge;loss of function;Magnetic Resonance Imaging;mineralization;Minority Groups;Mobility disability;Nervous System;novel;novel strategies;novel therapeutic intervention;Older Population;Outcome;Output;Pain;Pain management;Pain Measurement;pain sensitivity;Participant;Pathology;Patient Participation;Patients;personalized approach;personalized medicine;Phenotype;Physical activity;Pilot Projects;Prevention;prognostic;Proteins;Proteomics;Publishing;radiological imaging;Recommendation;reconstitution;recruit;Replacement Arthroplasty;Research Personnel;response;Risk;Risk Factors;Sample Size;Signal Transduction;Source;Synovial Fluid;Talents;therapeutic target;therapy development;treatment guidelines;Underrepresented Minority;Visualization;Work

PROJECT_TITLE: Novel Insights into Osteoarthritis, Pain and Function: MOST4


PI_NAMEs: FELSON, DAVID TOBIN (contact)

PROJECT_TERMS: Address;Aging;Agreement;Alabama;Ancillary Study;Area;Biomechanics;Boston;California;career;Clinical Data;cohort;Collaborations;Communication;Communities;community advisory board;Crystal Formation;Data;Data Collection;data management;data sharing;Degenerative polyarthritis;disability;Disease;Disputes;Ensure;Epidemiologic Factors;Etiology;experience;Faculty;Feedback;Fostering;Funding;Funding Agency;Goals;Grant;human subject;Image;innovation;insight;Institution;Institutional Review Boards;Iowa;Knee;Laboratories;Leadership;loss of function;Magnetic Resonance Imaging;Measurement;meetings;Mission;Monitor;multidisciplinary;Muscle function;novel;Observational Study;Occupational activity of managing finances;operation;Outcome;Output;Pain;Paper;patient oriented;Physical activity;Physical assessment;Policies;Postdoctoral Fellow;Prevention;Process;Productivity;programs;Protocols documentation;Publishing;Reaction;Reading;Recording of previous events;Regulation;Reporting;Research;Research Personnel;Risk Factors;San Francisco;United States National Institutes of Health;Universities

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Aging;Arthritis;Chronic Pain;Clinical Research;Osteoarthritis;Pain Research;Physical Activity

PI_NAMEs: CAWTHON, PEGGY MANNEN (contact)

PROJECT_TERMS: Address;Adherence;advanced disease;Alabama;Blood;Calcium;Clinic;Clinical;clinical center;Clinical Data;Collection;Complex;Crystal Formation;Data;data access;data cleaning;Data Collection;data management;data standards;Databases;Degenerative polyarthritis;Deposition;disability;disabling disease;Disease Progression;Enrollment;Ensure;ethnic minority population;Exclusion Criteria;Exercise;experience;follow-up;Fright;Goals;high risk;Image;Impairment;Incentives;Incidence;inclusion criteria;Infrastructure;insight;Institutional Review Boards;Iowa;Joints;Knee Osteoarthritis;Knowledge;Lead;Leadership;Life;mineralization;Monitor;Nervous System;novel;Observational Study;older adult;Outcome;Outcome Study;Pain;Participant;participant safety;Patient Recruitments;Phase;Physical activity;Prevalence;Procedures;Proteins;Proteomics;Protocols documentation;quality assurance;racial minority population;Reporting;Research;retention rate;Risk Factors;Safety;sample collection;Site;Specimen;success;Synovial Fluid;timeline;Universities;Visit;Work

PROJECT_TITLE: Core B-Clinical Data Collection and Management Core


NIH_SPENDING_CATS: Aging;Arthritis;Biomedical Imaging;Chronic Pain;Clinical Research;Osteoarthritis;Pain Research

PI_NAMEs: NEVITT, MICHAEL C (contact)

PROJECT_TERMS: Address;Adherence;Adopted;Agreement;Ancillary Study;Archives;Arthralgia;Attention;Cartilage;Certification;Clinic;clinical center;Collaborations;computerized data processing;Data;Data Analyses;data de-identification;data management;Data Set;data sharing;deep learning;Degenerative polyarthritis;digital;Disease;Dose;Ensure;Evolution;experience;Feedback;Funding;Glean;Goals;Grant;Hand;Image;image processing;imaging modality;insight;Joints;Knee;Limb structure;Lower Extremity;Machine Learning;Magnetic Resonance Imaging;Manuals;Measurement;Methods;Modeling;Monitor;Musculoskeletal;novel;operation;Pain;Pathogenesis;Pathology;Performance;Positioning Attribute;Procedures;programs;Protocols documentation;quality assurance;Radiology Specialty;Reader;Reading;Research Personnel;Roentgen Rays;Role;Secure;Site;Structure;Symptoms;System;Training;Training Programs;ultrasound;Update;Weight-Bearing state;Work;X-Ray Computed Tomography

PROJECT_TITLE: Core C:  Imaging Core


PI_NAMEs: LAVALLEY, MICHAEL PAUL (contact)

PROJECT_TERMS: Address;advanced analytics;analytical method;Blood;Calcium;Clinical;Clinical Data;clinically relevant;Crystal Formation;Data;Data Analyses;Data Analytics;Data Collection;data management;Degenerative polyarthritis;Deposition;design;Disease Progression;Ensure;Epidemiologist;Epidemiology;Exercise;experience;Fright;Funding;Goals;Grant;Image;Image Analysis;Impairment;Incidence;insight;Joints;Knee Osteoarthritis;Knowledge;Machine Learning;meetings;Methodology;Methods;mineralization;multidimensional data;Nervous System;novel;Observational Study;older adult;Pain;Physical activity;Policies;Procedures;Process;Proteins;Proteomics;Reproducibility;Reproducibility of Results;Research;Research Design;Research Personnel;Risk;Risk Factors;Role;Services;Site;Standardization;success;Synovial Fluid;Techniques;Training;Training and Education;Visualization;Work

PROJECT_TITLE: Core D:  Analysis Core


NIH_SPENDING_CATS: Aging;Arthritis;Behavioral and Social Science;Chronic Pain;Clinical Research;Neurosciences;Osteoarthritis;Pain Research;Physical Activity;Prevention

PI_NAMEs: NEOGI, TUHINA  (contact)

PROJECT_TERMS: Acute;Acute Pain;Address;Adult;adverse outcome;Arthritis;Attention;Autonomic nervous system;Belief;Biological;Central Nervous System;Chronic;chronic pain;cohort;Data;Degenerative polyarthritis;disability;Disease;Esthesia;Exercise;exercise intervention;exercise prescription;expectation;experience;Fright;functional decline;Functional disorder;functional outcomes;Future;heart rate variability;Impairment;improved;insight;Intervention;Knee Osteoarthritis;Knowledge;Light;Mediating;Movement;multisensory;Muscle Weakness;Nervous System;Nervous System Physiology;neurobiological mechanism;novel;novel strategies;older adult;osteoarthritis pain;Outcome;Pain;pain inhibition;Pain management;pain processing;pain reduction;pain sensitivity;Pain Threshold;Participant;Patient Self-Report;Persons;Physical activity;Physical Exercise;Physical Function;physical impairment;Physiological;Pilot Projects;Population;psychologic;psychological outcomes;quadriceps muscle;Recommendation;response;Rest;Risk;Risk Factors;Self Assessment;Sensory;Smell Perception;sound;Structure;System;targeted treatment;Testing;Touch sensation;Work

PROJECT_TITLE: Project 1:  Impaired Exercise Induced Hypoalgesia


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Precision Medicine;Radiation Oncology

ORG_CITY: CHICAGO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Radiotherapy regimens continue to be delivered using a “one-size-fits-all” paradigm and therefore do not currently take into account the genetic content of individual tumors. Our results indicate the primacy of Nrf2 and Braf as regulators of radiation resistance in non-small cell lung cancer. The deliverables of this proposal include new biomarkers calibrated on the basis of radiotherapeutic efficacy and new drug-radiation therapeutic strategies that more precisely and effectively target the most resistant lung tumors to radiation.

PI_NAMEs: ABAZEED, MOHAMED E. (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Acceleration;Accounting;actionable mutation;Adoption;Architecture;Biological Markers;biomarker driven;Biopsy Specimen;BRAF gene;Calibration;cancer cell;Cancer cell line;Cancer Etiology;Cancer Patient;cancer type;Catalogs;Catalytic Domain;Categories;Cell Survival;Cells;Cessation of life;Chemicals;chemoradiation;chemotherapy;Classification;Clinical;Clinical Research;clinical translation;Clinical Trials;clinically actionable;Collection;Complement;Data;Dependence;Drug Combinations;efficacy evaluation;Evolution;exome sequencing;Experimental Models;experimental study;Frequencies;Gene Expression;Genetic;Genetic Determinism;genetic variant;Genetic Variation;genomic data;Genomics;Geography;Goals;Immunofluorescence Immunologic;in vivo;Individual;individual patient;inhibitor;innovation;Investigation;kinase inhibitor;lung cancer cell;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;mathematical model;Measures;MEKs;Methods;Minor;Molecular;mortality;mouse model;Mutation;neoplastic cell;NF-E2-related factor 2;Non-Small-Cell Lung Carcinoma;novel therapeutics;Operative Surgical Procedures;Outcome;outcome prediction;palliative;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phosphatidylinositols;Phosphotransferases;PIK3CA gene;programs;Proto-Oncogene Proteins B-raf;Radiation;radiation resistance;radiation response;Radiation therapy;Radiation Tolerance;radioresistant;Radiosensitization;Recurrence;Regimen;Research;Resistance;response;Role;Sampling;standard of care;synergism;targeted treatment;Technology;Testing;Therapeutic;Time;Translations;tumor;Tumor Cell Line;tumor DNA;United States;Variant;Work

PROJECT_TITLE: A biomarker-driven strategy to guide the use of radiotherapy in non-small cell lung cancer


NIH_SPENDING_CATS: Aging;Arthritis;Biotechnology;Chronic Pain;Clinical Research;Osteoarthritis;Pain Research;Prevention

PROJECT_TERMS: aged;aptamer;Arthralgia;Arthritis;Biological Assay;Biological Markers;Biology;biomarker identification;Biomechanics;Blood;Cartilage;cohort;cost;Degenerative polyarthritis;Development;Disease;Disease Progression;early detection biomarkers;Functional disorder;Goals;Hand;Hand Osteoarthritis;Incidence;Individual;insight;International;Joints;Knee;Knee Osteoarthritis;knee pain;Knowledge;Magnetic Resonance Imaging;Measures;Mechanics;Molecular;Molecular Profiling;novel;novel marker;novel therapeutic intervention;Older Population;osteoarthritis pain;Outcome;Pain;Participant;Pathogenesis;Pathogenicity;Pharmacological Treatment;physically handicapped;Plasma;Plasma Proteins;Process;progression risk;Prospective cohort;Proteins;Proteome;proteomic signature;Proteomics;radiological imaging;Research Design;Risk Assessment;Risk Factors;Sampling;Site;success;Synovial Fluid;Tissues;ultrasound;United States;Visit

PROJECT_TITLE: Project 2:  Synovial Fluid Proteomics


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Severe pneumonia is characterized by an increased bacterial burden, exaggerated host immune response, and cellular damage in the lungs, and is a leading cause of death worldwide. There is an urgent need to better understand host defense mechanisms in the lung, with the goal of yielding new therapies to improve pneumonia treatment. Our proposal directly addresses this need by investigating and employing Factor B — a complement protein that is an important part of the host immune response for killing pathogenic bacteria — to reduce the morbidity and mortality associated with pneumonia by leveraging its ability to protect the lung.

PI_NAMEs: KULKARNI, HRISHIKESH SATISH (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acute;Acute Pneumonia;Address;airway epithelium;alveolar epithelium;Anabolism;Area;arm;Attenuated;Bacteremia;Bacteria;Bacterial Infections;Bacterial Pneumonia;Binding;Biochemical;Biological Assay;Bronchopneumonia;Cause of Death;Cell Death;Cell Death Induction;cell injury;Cell secretion;Cell Survival;Cells;cellular imaging;Cessation of life;Circulation;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;Complement 3 Convertase;Complement 3a;Complement 3b;Complement Activation;Complement Factor B;complement system;CRISPR screen;Cytoprotection;Data;Deposition;design;Enzymes;Epithelial Cells;Epithelium;Gene Delivery;gene therapy;Genetic;Goals;Host Defense;Host Defense Mechanism;Human;human model;humoral immunity deficiency;Immune response;improved;In Vitro;in vivo;Individual;Infection;Inflammatory Response;Knock-out;Knowledge;knowledge integration;Libraries;Ligands;Liquid substance;Liver;Lung;lung injury;Mediating;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mucous Membrane;Mus;mutant;National Heart, Lung, and Blood Institute;novel;novel therapeutics;overexpression;oxidant stress;pathogen;pathogenic bacteria;Pathway interactions;Pattern;pharmacologic;Plasmids;Pneumonia;pneumonia treatment;Predisposition;protective effect;protein transport;Proteins;Proteomics;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Pseudomonas aeruginosa pneumonia;pulmonary function;receptor;Reporting;Research;Research Priority;resilience;Role;Severities;Site;Source;Stress;Structure-Activity Relationship;Surface;Testing;Tissues;Transfection;Transgenic Mice;uptake;Work;working group

PROJECT_TITLE: Lung-derived complement in pneumonia

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative A severe complication of influenza infection is secondary Staphylococcus aureus, and previous data has shown that type I interferons produced during influenza infection result in a defective bacterial immune response. Type III interferons are a more recently discovered family of interferons that share signaling pathways with type I interferons. This project will determine the role of type III interferons in impairment of the immune response against secondary bacterial infection by decreasing lung macrophage function and subsequent type 17 immune induction.

PI_NAMEs: ANTOS, DANIELLE  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Activities of Daily Living;Affect;Alveolar;Antigen Presentation;Antigen-Presenting Cells;Attenuated;attenuation;Bacterial Antigens;Bacterial Infections;Benefits and Risks;Biological Assay;Cause of Death;CD4 Positive T Lymphocytes;cell type;Cells;Complication;cytokine;Data;Dendritic Cells;Environment;Enzyme-Linked Immunosorbent Assay;Epithelial Cells;Epithelium;Exhibits;experimental study;extracellular;Family;Flow Cytometry;Foundations;functional outcomes;Future;Human;IFNGR1 gene;IL17 gene;Immune;Immune response;Immunity;Impairment;In Vitro;in vitro Assay;in vivo;Incubated;Infection;Inflammatory;Influenza;influenza infection;insight;Interferon alpha;Interferon Type I;Interferon Type II;Interferons;interleukin-22;interstitial;Label;Laboratories;Lung;Lung Diseases;lung injury;Macrophage;Measures;methicillin resistant Staphylococcus aureus;Methods;monocyte;Morbidity - disease rate;mortality;Mucous Membrane;Mus;Myelogenous;Myeloid Cells;neutrophil;Outcome;Ovum;pathogen;Pathway interactions;Phagocytosis;Population;Predisposition;Prevalence;Process;Production;receptor;receptor expression;Recombinant Interferon;recruit;Resolution;respiratory pathogen;Respiratory System;response;Role;Secondary to;Severities;Signal Pathway;Signal Transduction;Staphylococcus aureus;Staphylococcus aureus infection;superinfection;Syndrome;Therapeutic;uptake;Viral;Visual;Wild Type Mouse

PROJECT_TITLE: Impact of interferon λ signaling on lung macrophage function and type 17 immunity during bacterial super-infection following influenza


PROJECT_TERMS: Acute;Address;Algorithms;Anatomy;Anti-Cytokine Therapy;Arthritis;Blood;C-reactive protein;calcification;Calcium;calcium phosphate;Calcium Pyrophosphate;Calcium pyrophosphate deposition disease;cardiovascular risk factor;Cartilage;clinically relevant;Collection;Crystal Formation;cytokine;Data;deep learning;Degenerative polyarthritis;Development;differential expression;Disease;experience;Foundations;IL18 gene;Image;Image Analysis;Incidence;Individual;Inflammation;Inflammatory;inflammatory marker;innovation;insight;Interleukin-1 beta;Interleukin-6;Joints;Knee;Knee Osteoarthritis;knee pain;Knowledge;Location;Magnetic Resonance Imaging;Meniscus structure of joint;Methods;mineralization;Modification;novel;Outcome;Pain;Pathology;Pathway interactions;Pattern;Persons;Phenotype;Physics;Placebos;Prevalence;Prevention strategy;Proteomics;Pseudogout;Questionnaires;radiological imaging;Replacement Arthroplasty;Research;Role;Serum;Shoulder;soft tissue;Spectroscopy, Fourier Transform Infrared;Subgroup;Symptoms;Synovial Fluid;systemic inflammatory response;Testing;Traction;treatment strategy;two-dimensional;ultrasound;Urate;Work;X-Ray Computed Tomography

PROJECT_TITLE: Project 3:  Intraarticular Mineralization


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Regenerative Medicine

ORG_CITY: SAN FRANCISCO

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Orthodontic relapse is one of the most challenging and ubiquitous problems in the field that leads to negative treatment outcomes for orofacial aesthetics, oral functions, and increases the risk of dental disease as well as the health care cost burden. Biologic therapies that mitigate this response have shown promise in animal models, but the lack of appropriate drug delivery systems has precluded their translation. The experiments outlined in this application will elucidate the use of anti-osteoclastic OPG administered for local and sustained release via an osteoconductive hydroxyapatite drug delivery system to mitigate relapse.

PI_NAMEs: CUYLEAR, DARNELL  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Acceleration;Address;Adopted;adverse outcome;Aftercare;alveolar bone;Anabolism;Animal Model;Back;Binding;Biological;Biological Assay;Biological Process;Biological Products;Biological Response Modifier Therapy;biomaterial compatibility;Bolus Infusion;bone;bone metabolism;bone quality;Bone Regeneration;bone repair;Bone Resorption;bone turnover;chemical property;Clinical;clinically relevant;controlled release;Data;Defect;Dental caries;Development;Disease;Dose;Drug Delivery Systems;Elements;Engineering;Ensure;Esthetics;experience;experimental study;Financial Hardship;Genes;Goals;Health Care Costs;Hydroxyapatites;Imaging Techniques;Immature Bone;Impairment;impression;improved;In Vitro;in vitro activity;in vivo;Injectable;Injections;insight;Intervention;Kinetics;Knowledge;Mastication;Mechanics;Mediating;Methods;Modeling;Molds;Molecular;Natural regeneration;non-compliance;novel;novel strategies;novel therapeutic intervention;Oral;orofacial;Orthodontic;Osteoclasts;Osteogenesis;Osteolysis;Outcome;particle;Pathologic Processes;Pathway interactions;Patient Compliance;Patients;Periodontal Diseases;Periodontium;Persons;Phase;Positioning Attribute;Predisposition;Property;Proteins;Protocols documentation;Rattus;Recombinants;Relapse;repaired;response;Retreatment;Risk;Site;Speech;Stains;Submucosa;System;Testing;Therapeutic;Therapeutic Uses;Tissues;Tooth Diseases;Tooth Movement;Tooth structure;transcriptome sequencing;transcriptomics;Translations;Treatment Efficacy;Treatment outcome;Tumor necrosis factor receptor 11b

PROJECT_TITLE: Local Sustained Delivery of Osteoprotegerin via Hydroxyapatite Microparticles to Enhance Post-Orthodontic Tooth Stability

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Clinical Research;Microbiome;Neurosciences;Substance Misuse

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Projective Narrative The objective of this proposal is to characterize the microbiome-gut-brain axis in individuals with AUD. Specifically, this proposal seeks to evaluate the relationship between gut dysbiosis, clinical phenomenology of AUD, and a brain-based biomarker in individuals with AUD and matched controls. This study has important clinical implications as it will provide the first data linking the gut-brain axis to AUD in a single sample of human participants.

PI_NAMEs: GRODIN, ERICA N (contact)

PROGRAM_OFFICER_NAME: AKBAR, MOHAMMED

PROJECT_TERMS: 16S ribosomal RNA sequencing;addiction;alcohol craving;alcohol cue;alcohol response;alcohol use disorder;Alcohols;Animal Model;Anxiety;Award;Bacteria;Beverages;Big Data;Biological Markers;Blood specimen;brain based;Cells;Central Nervous System;Chronic;chronic alcohol ingestion;Clinical;Clinical assessments;Corpus striatum structure;cue reactivity;Cues;Data;design;Development;disorder control;dysbiosis;Emotional;Executive Dysfunction;experience;FABP2 gene;Goals;Growth;gut bacteria;gut dysbiosis;gut microbiome;gut microbiota;gut-brain axis;Homeostasis;Human;incentive salience;Individual;intestinal homeostasis;Intestinal permeability;Investigation;Link;Machine Learning;Mental Depression;Mentored Research Scientist Development Award;Mentors;Methods;microbial;microbiome analysis;microbiome composition;microbiota;microbiota-gut-brain axis;Modeling;neural;neural circuit;neuroimaging;Neurosciences;non-alcoholic;Participant;Pathogenesis;pathogenic bacteria;phenomenological models;Phenotype;Positioning Attribute;pre-clinical;problem drinker;Process;Public Health;random forest;Recurrent disease;Research;Research Personnel;Role;Sampling;Scientist;Serum;stool sample;Testing;therapy development;Training;Work

PROJECT_TITLE: Characterizing the Microbiome-Gut-Brain Axis in Individuals with Alcohol Use Disorder

STUDY_SECTION: AA

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Cerebrovascular;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Emerging Infectious Diseases;Genetics;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences;Prevention;Sexually Transmitted Infections;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BALTIMORE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Alzheimer’s disease is a public health crisis with no disease-modifying treatment, so prevention is key to reducing its prevalence. The proposed research will elucidate the extent to which infection with Herpes Simplex Virus Types 1 and 2, Cytomegalovirus, Epstein-Barr Virus, Toxoplasma gondii—measured four times over ~25 years—and SARS-CoV-2 (the virus that causes COVID-19) are associated with subsequent cognitive and functional decline and diagnoses of mild cognitive impairment and dementia, measures of Alzheimer’s disease pathology from blood samples, and accelerated biological aging. Results will advance our understanding of whether common infections increase the risk for Alzheimer’s disease and related dementias and how they might do so.

PI_NAMEs: MAHER, BRION S;SPIRA, ADAM PETER (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: 2019-nCoV;abeta deposition;actigraphy;adjudication;Affect;Age;age acceleration;Aging;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;American;Amyloid beta-Protein;Antibodies;Anxiety Disorders;Apolipoprotein E;Area;Attention;Baltimore;Biological;Biological Aging;Biological Assay;Biology of Aging;Blood;Blood specimen;blood-based biomarker;Brain;brain health;Catchment Area;CD8-Positive T-Lymphocytes;CDKN2A gene;Cell Aging;Chronic;Cognitive;Cognitive aging;cognitive performance;cognitive testing;cohort;Communicable Diseases;COVID-19;Cyclin-Dependent Kinase Inhibitor;Cytomegalovirus;Data;Data Collection;Dementia;dementia risk;Depressive disorder;Development;Diagnosis;Diagnostic;Disease;epidemiologic data;Epidemiology;epigenetic clock;Epigenetic Process;Etiology;Exhibits;follow-up;functional decline;Future;Genetic;Genetic Risk;genome-wide;genomic data;Genotype;Growth;Health;Healthcare Systems;Herpesvirus 1;Human;Human Herpesvirus 2;Human Herpesvirus 4;hyperphosphorylated tau;Immune response;Impaired cognition;Individual;Infection;Inflammation;interest;Interview;latent infection;Length;Life;Life Style;Light;Link;Longitudinal cohort;Measures;Mental disorders;Methylation;microbial;mild cognitive impairment;Mind;modifiable risk;Modification;mouse model;Nerve Degeneration;neurofilament;neuroinflammation;Neuropsychology;Neurovirology;novel;novel therapeutics;older adult;Older Population;Outcome;Participant;pathogen;Pathway interactions;Performance;Persons;Physiological;Plasma;poor sleep;Prevalence;Prevention;Preventive;Public Health;reactivation from latency;Reporting;Research;Risk;Risk Factors;risk variant;Role;Sampling;SARS-CoV-2 infection;senescence;senescence associated secretory phenotype;seropositive;Severe Acute Respiratory Syndrome;sex;Simplexvirus;Stress;Stressful Event;stressor;Structure;Subgroup;Symptoms;T cell differentiation;T cell response;tau Proteins;telomere;Telomere Shortening;Testing;Therapeutic;Time;Toxoplasma gondii;traumatic event;Viral;Virus;Woman;Work;Wrist

PROJECT_TITLE: Microbial Impact on NeuroDegeneration in Alzheimer's Dementia: MIND-AD


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Disability Research;Social Determinants of Health

ORG_CITY: JACKSON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: JACKSON STATE UNIVERSITY

ORG_STATE: MS

PHR: Project Narrative We propose to establish a new national training program designed to increase the size of a highly skilled, successful, and diverse behavioral and biomedical workforce. We will do so through workshops that train researchers who work in a variety of venues to transmit essential professional skills to trainees at their home institutions or scientific societies. Those skills will include preparing grant proposals and manuscripts; securing and maintaining jobs; teaching and mentoring; time, stress, and conflict management; and the responsible conduct of research. Special emphasis will be placed on ensuring that the instructors, the workshop participants, and the participants’ trainees include both ethnic diversity and people with disabilities. Careful evaluation of our effectiveness will occur throughout.

PI_NAMEs: CAMPBELL, ALMESHA L. (contact);HOIT, JEANNETTE D.;TORRES, GONZALO E.

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Active Learning;Address;Administrator;Applications Grants;Behavioral;Behavioral Research;Biomedical Research;career;Climate;Communication;Communities;Conflict (Psychology);conflict resolution;Consultations;cultural competence;Data;Data Reporting;design;Development;Dimensions;disability;Disabled Persons;Discipline;Diverse Workforce;Ecosystem;Educational Materials;Educational process of instructing;Educational workshop;Effectiveness;Electronics;Elements;Employment;Ensure;Environment;Ethics;ethnic diversity;ethnic minority;Ethnic Population;Evaluation;Exhibits;Faculty;follow-up;Funding;graduate student;high standard;Home;improved;Individual;Industry;innovation;Institution;Instruction;instructor;Intuition;Laboratories;Language;Leadership;Learning;Manuals;Manuscripts;member;Mentors;Methods;National Institute of General Medical Sciences;Occupations;Online Systems;Oral;outreach;Participant;Persons;Postbaccalaureate;Postdoctoral Fellow;posters;Privatization;Professional Organizations;Professional Practice;programs;Publishing;Reproducibility;Research;Research Ethics;Research Institute;Research Personnel;Research Training;Resources;response;responsible research conduct;Science;Scientific Societies;Scientist;Secure;Services;skill acquisition;skills;Slide;Social Responsibility;Source;Stress;Students;success;Teacher Professional Development;Time;Time Management;tool;Trainers Training;Training;Training Programs;transmission process;university student;Update;web site;Work;Workplace;Writing

PROJECT_TITLE: A Train-the-Trainers Approach to Developing a Diverse and Successful Workforce in Behavioral and Biomedical Sciences


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: Chicago

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: PROJECT NARRATIVE Cancer vaccines based on peptide tumor antigens have been shown to be an effective treatment option for various cancer states. However, challenges in the delivery and protection of these peptides from degradation and clearance have severely limited their clinical utility. This proposal seeks to address these challenges by utilizing a novel peptide delivery system that allows for the protected delivery of tumor antigens, either alone or in proportion-controlled combinations with multiple different antigens and immunomodulatory compounds.

PI_NAMEs: WANG, MAX  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Address;Adjuvant;Affect;Agonist;Amides;Amino Acids;anti-cancer;anti-PD-1/PD-L1;anti-PD-L1 antibodies;anti-tumor immune response;Antigen-Presenting Cells;Antigens;Antitumor Response;Architecture;Area;Autoimmunity;cancer cell;cancer immunotherapy;Cancer Vaccines;Cell Proliferation;Cells;central tolerance;Characteristics;Chemistry;Clinical;Colon Carcinoma;Combination immunotherapy;combinatorial;Complex;copolymer;Cross Presentation;CT26;cytokine;Data;density;design;Development;disulfide bond;Disulfide Linkage;Drug Kinetics;early phase clinical trial;effective therapy;effectiveness evaluation;efficacy testing;Esters;Exhibits;experimental study;Formulation;Generations;gp100 Antigen;Harvest;Heterophile Antigens;High Pressure Liquid Chromatography;Human papillomavirus 16;Hydrophobicity;Immune;Immune response;immunogenic;immunoregulation;improved;in vitro Assay;in vivo;Incubated;insight;interest;Kinetics;Label;Length;Libraries;Malignant Neoplasms;Mediating;Melanoma;melanoma-associated antigen;Methodology;Methods;Modeling;Molecular Weight;Mus;nanoparticle;nanopolymer;nanotechnology platform;neoantigens;Neoplasm Transplantation;novel;Nucleic Acids;Oncoproteins;Ovalbumin;Patients;Peptides;peripheral tolerance;physical property;polymerization;Polymers;Post-Translational Protein Processing;Predisposition;preservation;prevent;Production;Property;Proteins;Proteolysis;rational design;Reaction;Resistance;Risk Reduction;Side;Signal Transduction;SILV gene;Site;small molecule;Somatic Mutation;spatiotemporal;STING agonists;Structure;Structure-Activity Relationship;Subunit Vaccines;synergism;System;T-Lymphocyte;targeted delivery;Testing;Therapeutic;three dimensional structure;Time;Tissues;Transgenic Organisms;treatment optimization;Treatment Protocols;tumor;Tumor Antigens;Tumor Burden;Tumor Immunity;uptake;Vaccination;vaccine efficacy;vaccine formulation;Vaccines;Vertebral column

PROJECT_TITLE: Development of Rationally Designed Cancer Vaccines Using Protein-like Polymers (PLPs)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-U(20)L]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Digestive Diseases;Microbiome;Neurodegenerative;Neurosciences

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative While an infectious etiology has been proposed to be involved in Alzheimer’s disease, more evidence is needed. We have found that intestinal Bacteroides can increase amyloid-beta plaques in animal models of Alzheimer’s disease, and will now test whether AD patients harbor Bacteroides strains that can contribute to AD. Through the identification of novel pathogenicity factors for AD, this research may lead to new strategies to prevent and treat AD.

PI_NAMEs: COX, LAURA MICHELLE (contact)

PROJECT_TERMS: Address;Affect;aged;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Animal Model;APP-PS1;Bacteria;Bacteroides;Bacteroides fragilis;Brain;Cell Wall;Chronic;Comparative Genomic Analysis;Data;Degradation Pathway;Diagnosis;Disease;DNA Sequence Alteration;Endoplasmic Reticulum;Etiology;Exhibits;fragilysin;Gene Expression;Genes;Genetic Transcription;Genomics;gut inflammation;gut microbiota;Histologic;Human;human disease;immunoreactivity;immunoregulation;Impairment;In Vitro;in vitro Assay;in vivo;Infection;Infectious Agent;insight;Insulinase;Intestines;Macrophage;Measures;Memory;Metagenomics;metatranscriptomics;Metronidazole;microbiota;Microglia;Molecular;monocyte;mouse model;Mus;Nature;Nervous System Disorder;neuron loss;Neurons;neurotoxicity;Neurotransmitters;nonalzheimer dementia;novel;Pathogenesis;Pathway interactions;Phagocytosis;Play;prevent;Prevention;Process;protein degradation;Proteins;Research;response;Role;Senile Plaques;Shotguns;Signal Pathway;stool sample;systemic inflammatory response;tau aggregation;tau Proteins;tau-1;Testing;Tight Junctions;Toxin;transcriptomics;Variant;Virulence Factors

PROJECT_TITLE: Investigating the strain-specific role of Bacteroides in the etiology of Alzheimer's disease


NIH_SPENDING_CATS: Brain Disorders;Intellectual and Developmental Disabilities (IDD);Lung;Neurosciences;Pediatric;Rare Diseases;Rett Syndrome;Women's Health Research

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: PROJECT NARRATIVE Rett syndrome (RTT) is a neurodevelopmental disorder with a high mortality rate caused in part by respiratory dysfunction. RTT is caused by mutations in the gene encoding methyl-CpG-binding protein 2 (MECP2) and evidence suggests MeCP2 regulates expression of astrocyte Kir4.1 channels; however, it is not known how loss of MeCP2 or Kir4.1 channels disrupts breathing. This project seeks to identify astrocytes and Kir4.1 channels as the cellular and molecular basis for breathing problems in a mouse model of RTT.

PI_NAMEs: STRAIN, MONICA  (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: adenovirus mediated delivery;Affect;Animal Model;Animals;Astrocytes;autistic behaviour;Behavior;Brain;Brain Stem;Breathing;Carbon Dioxide;Cell Nucleus;Cessation of life;comorbidity;Data;Death Rate;Disease;Electrophysiology (science);extracellular;Failure;Future;Genes;Genotype;Goals;Homeostasis;human model;In Vitro;insight;Link;loss of function mutation;Mediating;Membrane Potentials;Methyl-CpG-Binding Protein 2;Molecular;mouse model;Mus;Mutation;Neurodevelopmental Disorder;Neurons;Online Mendelian Inheritance In Man;Patients;Phenotype;Positioning Attribute;premature;Process;Quality of life;Reflex action;Regulation;Research Personnel;Respiration Disorders;respiratory;response;Rett Syndrome;Role;Science;Seizures;Site;Slice;Symptoms;targeted treatment;Testing;Tissues;Training;training opportunity;Wakefulness;Whole Body Plethysmography;Work

PROJECT_TITLE: Contributions of Astrocyte Kir4.1/5.1 Channels to Disordered Breathing in Rett Syndrome


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Clinical Research;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Neurosciences;Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE While HIV persistence in resting T cells has been extensively characterized, the role of HIV in brain myeloid cells (BMC) as a reservoir and as a source of rebound upon cessation of antiretroviral treatment (ART) is yet to be determined. Using CNS tissues from 20 participants enrolled in the Last Gift cohort (an ongoing rapid autopsy study), we will determine the role of BMC: (i) in the maintenance of HIV reservoir across the CNS with different ART and opioid penetration, (ii) as a source for HIV dispersal, and (iii) in inflammation-induced neurological damage. This will provide new insights for the development of strategies to effectively clear HIV infection and lessen HIV-associated neurological damage.

PI_NAMEs: CHAILLON, ANTOINE  (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: Accounting;Address;Aftercare;Altruism;Anti-Retroviral Agents;antiretroviral therapy;Autopsy;Basal Ganglia;Binding;Biological Assay;Blood;Blood - brain barrier anatomy;Brain;brain cell;brain health;Brain Injuries;Cd68;CD86 gene;Cell Death;Cell Death Signaling Process;Cell Density;cell injury;cell motility;Cell Physiology;Cell Separation;Cells;Central Nervous System;Cerebellum;Cerebrospinal Fluid;Cessation of life;Characteristics;Clonal Expansion;cohort;Consequences of HIV;cytokine;Data;density;Development;DNA;Enrollment;Event;frontal lobe;Gene Expression;Genes;Genetic Transcription;genome sequencing;Gifts;Goals;gray matter;Heterogeneity;Hippocampus;HIV;HIV Infections;HIV-1;Human;IL18 gene;ileum;Immune response;improved;Inflammasome;Inflammation;Inflammatory;insight;integration site;Interleukin-1 beta;Interruption;Intervention;ITGAX gene;Knowledge;Length;Linear Models;Literature;Macrophage;Maintenance;Maps;Measures;Microglia;migration;Modeling;Modernization;Myeloid Cell Activation;Myeloid Cells;Nervous System Trauma;Neurocognitive;neuroinflammation;Neurons;Opioid;opioid exposure;opioid use;Organ;Parents;Participant;participant enrollment;Pathway interactions;Pattern Recognition;Pattern recognition receptor;Penetration;Peripheral;Persons;Pharmaceutical Preparations;pharmacologic;Phenotype;Population;Predisposition;prescription opioid;Process;protein expression;Proviruses;Residual state;Rest;RIPK1 gene;RNA;Role;single-cell RNA sequencing;Site;Sorting;Source;Spinal Cord;Spleen;T-Lymphocyte;Thalamic structure;Time;Tissues;TNF gene;trafficking;trait;transcriptomics;transmission process;Viral;Virus;white matter

PROJECT_TITLE: Brain Myeloid Cells are Sources of HIV-associated Damage and Viral Dispersal


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

PHR: Project Narrative Most disease-associated genetic variants are suspected to act by regulation of expression of a nearby gene, yet in most cases these regulatory effects have not yet been identified. One challenge for efforts to map these disease loci to target genes is that their regulatory effects are often highly context-specific, varying between cell types or tissues. This work will use a human embryoid body system to study an expansive array of dynamic contexts involved in cellular differentiation, revealing novel dynamic genetic regulatory effects on gene expression and improving our ability to map disease loci to target genes.

PI_NAMEs: POPP, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: FUFA, TEMESGEN D

PROJECT_TERMS: 3-Dimensional;Acceleration;Adult;Biological;Biological Assay;Body mass index;Body System;Cell Differentiation process;cell type;Cells;Chicago;Chromatin;Complex;Computing Methodologies;Coronary Arteriosclerosis;Data;Data Set;Disease;disorder risk;Embryoid bodies;Fetal Tissues;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Risk;genetic variant;Genetic Variation;Genome;genome wide association study;genomic locus;Heterogeneity;Human;human disease;human embryoid body;Human Genetics;Human Genome;improved;In Vitro;in vivo;Individual;Individual Differences;induced pluripotent stem cell;insight;Link;Maps;Measures;Mediating;Modeling;Molecular;Noise;novel;Nucleic Acid Regulatory Sequences;Pattern;Positioning Attribute;Quantitative Trait Loci;Regulation;Research;Research Personnel;risk variant;Sampling;Schizophrenia;single cell analysis;single-cell RNA sequencing;Specificity;Statistical Methods;Statistical Models;statistics;System;Testing;Tissue Sample;Tissues;tool;trait;Universities;Validation;Variant;Work

PROJECT_TITLE: Dynamic genetic regulation of gene expression in diverse differentiation trajectories with human embryoid bodies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Atherosclerosis is the most common underlying cause of cardiovascular disease and is characterized by unresolved chronic inflammation of the vessel wall. Despite the availability of efficient low-density lipoprotein lowering therapies, there remains substantial residual inflammatory risk. As there are no approved therapies limiting the inflammation that contributes to plaque development, we propose to explore the role of the IRG1- itaconate axis in regulating the immune environment within the atherosclerotic plaque, which can be leveraged to treat atherosclerotic cardiovascular disease in a novel way.

PI_NAMEs: BOZAL, FAZLI KAMER (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Aconitic Acid;activating transcription factor 3;Acute;Acute Disease;Agonist;Anti-Inflammatory Agents;anti-microbial drug;Antibodies;Aorta;Area;Arterial Fatty Streak;Arteries;ATF2 gene;Atherosclerosis;Cardiovascular Diseases;Cardiovascular system;Cause of Death;Cell Physiology;Cells;Cellular Metabolic Process;Cessation of life;Cholesterol;Chromatin;Chronic;chronic inflammatory disease;Citric Acid Cycle;Classification;Clinical Trials;cytokine;Data;Development;Economic Burden;Environment;Enzymes;Event;extracellular;Failure;FDA approved;feeding;Gene Expression Regulation;Genes;IL6 gene;Immune;immune activation;Immune Tolerance;immunoregulation;In Vitro;in vivo;indexing;Infection;Infiltration;Inflammasome;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;Interferons;Interleukin-1 beta;Kinetics;LDL Cholesterol Lipoproteins;Lesion;Ligands;Lipids;Lipopolysaccharides;Low-Density Lipoproteins;Macrophage;Measures;Metabolic;Metabolic Pathway;Metabolism;microbial;Modality;Modification;monocyte;mouse model;Mus;Myeloid Cells;Myocardial Infarction;Necrosis;neutrophil;novel;novel therapeutics;nuclear factor-erythroid 2;overexpression;oxidized low density lipoprotein;particle;Pathogenesis;Pathway interactions;patient subsets;Peptide Hydrolases;Permeability;Pharmaceutical Preparations;prevent;Production;Reactive Oxygen Species;recruit;Regulation;Research;Residual state;Risk;Role;Sampling;Sepsis;single cell ATAC-seq;single-cell RNA sequencing;standard of care;Stimulus;Stroke;systemic inflammatory response;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Therapeutic Effect;Thick;Thrombosis;Time;Toll-like receptors;transcription factor;transcriptome;Up-Regulation;western diet;Wild Type Mouse;Work

PROJECT_TITLE: The role of Immune-responsive gene 1 and itaconate in atherosclerotic disease


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Substance Misuse

ORG_CITY: BRENTWOOD

ORG_NAME: COLLEGE ON PROBLEMS OF DRUG DEPENDENCE

ORG_STATE: TN

PHR: PROJECT NARRATIVE The mission of the College on Problems of Drug Dependence (CPDD) annual conference directly aligns with that of NIDA (i.e., to support the advancement and dissemination of knowledge on the neuroscience, medications development, treatment research and translational studies of substance use and its attendant problems). The primary purpose of this competing renewal application is to support attendance at, and participation in, the CPDD annual meeting for trainees, early career researchers, underrepresented minorities and international scientists and to foster their career development in substance use research.

PI_NAMEs: HASIN, DEBORAH S (contact)

PROJECT_TERMS: Academia;Acceleration;addiction;Address;Administrator;Adopted;Alcohols;Animals;Anti-Anxiety Agents;Area;Award;Behavior;Cannabis;career;career development;Career Mobility;Clinical;Collaborations;college;Computer software;Country;Dedications;Development;Discipline;doctoral student;Drug Addiction;drug of abuse;Epidemiology;epidemiology study;Equipment;experience;Fostering;Funding;Future;Genetic;Government;Grant;Hallucinogens;health disparity;Health Services;HIV/AIDS;Human;hypnotic;improved;Industry;innovation;interest;International;Knowledge;Learning;lectures;Medicine;meetings;Mentors;Mission;Molecular Biology;National Institute of Drug Abuse;Nature;neuroimaging;Neurosciences;Nicotine;Nurses;Online Systems;Opioid;outreach;Participant;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacology;Physicians;Policies;Policy Maker;posters;pre-doctoral;Prevention;programs;Psychologist;Psychology;Public Health;Public Policy;Research;Research Personnel;research study;Scientific Societies;Scientist;sedative;Sociology;Stimulant;substance use;Substance Use Disorder;substance use treatment;symposium;Training Activity;translational study;Travel;treatment research;Underrepresented Minority;Underrepresented Populations;United States;virtual

PROJECT_TITLE: Scientific Conferences for The College on Problems of Drug Dependence (CPDD)


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: NEUROSCIENCES

PHR: PROJECT NARRATIVE Based on our extensive preliminary data we now believe we have determined the degradation event that may underlie nuclear pore injury loss that occurs early in the pathogenesis of ALS/FTD. Our preliminary experiments suggest that this novel disease pathway can be pharmacologically manipulated. Thus, candidate ASO therapy could be useful for C9orf72 ALS/FTD patients. Furthermore, the pathological reduction of nucleoporins that make up the nuclear pore complex are present in a substantial subset of sporadic ALS patients and nuclear pore complex injury is a common feature of diseases caused by mutations in specific nucleoporins, Alzheimer’s disease, and Huntington’s disease. As a result, therapeutic targeting of nucleoporin and nuclear pore complex degradation and CHMP7 has potential to extend far beyond C9orf72 mediated disease.

PI_NAMEs: LUSK, CHARLES PATRICK;ROTHSTEIN, JEFFREY D (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Accounting;ALS patients;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Autopsy;Biochemical;Biological Assay;Brain;C9ORF72;Cell Line;Clinical;Complex;Data;Defect;Degradation Pathway;Dementia;Disease;Disease Pathway;efficacy evaluation;Event;Excision;experimental study;familial amyotrophic lateral sclerosis;frontotemporal lobar dementia amyotrophic lateral sclerosis;Genes;genetic manipulation;Genetic Transcription;Homeostasis;Human;human tissue;Huntington Disease;Image;imaging approach;Impairment;Individual;individual patient;induced pluripotent stem cell;Injury;Investigation;knock-down;Link;Mammalian Cell;Mediating;Membrane;Molecular;Mutation;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neurons;novel;Nuclear;Nuclear Envelope;Nuclear Export;Nuclear Pore;Nuclear Pore Complex;Nuclear Pore Complex Proteins;nucleocytoplasmic transport;Nucleoplasm;Pathogenesis;Pathologic;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Peptides;pharmacologic;Phenotype;Proteins;Quality Control;RNA;RNA metabolism;Series;Spinal;sporadic amyotrophic lateral sclerosis;stressor;therapeutic candidate;therapeutic target;Work;Yeasts

PROJECT_TITLE: Nuclear pore complex quality control in ALS/FTD


NIH_SPENDING_CATS: Biotechnology;Cooley's Anemia;Genetics;Hematology;Orphan Drug;Rare Diseases;Sickle Cell Disease

ORG_CITY: NEW HAVEN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: YALE UNIVERSITY

PHR: The major -hemoglobinopathies, sickle cell disease (SCD) and -thalassemia, are two of the most common monogenetic diseases. Although gene therapy by CRISPR gene editing and lentiviral gene delivery have been shown to correct the -globin gene mutations in SCD and -thalassemia, initial clinical efforts have shown low correction frequencies or have resulted in the serious side effects of anemia, leukopenia, neutropenia, thrombocytopenia, or a combination. Harnessing techniques of targeted protein degradation against transcription factors critical in the -globin to -globin switch, namely BCL11A, ZBTB7A, and ZNF410, to reactivate -globin expression and fetal hemoglobin expression is a novel therapeutic avenue towards developing much needed treatments for sickle cell disease and -thalassemia.

PI_NAMEs: ZHENG, SIJIN  (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Academic skills;Adult;Anemia;Antibodies;autosome;Basic Science;Biochemistry;Biological;Biological Assay;Birth;Bone Marrow;Calorimetry;CD34 gene;Cell Differentiation process;Cell Survival;Cells;Cellular biology;CHD4 gene;Chemistry;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Computer software;CRISPR/Cas technology;Cullin Proteins;Deacetylase;Dependence;design;Development;Disease;Dose;Environment;Erythrocytes;Erythroid Cells;Erythroid Progenitor Cells;fetal;Fetal Hemoglobin;Fetal Liver;Firefly Luciferases;Flow Cytometry;Frequencies;Gene Delivery;Gene Mutation;gene therapy;Genes;Genetic Transcription;Globin;Glutamic Acid;Goals;Hematopoiesis;Hemoglobin;Hemoglobin concentration result;Hemoglobinopathies;High Pressure Liquid Chromatography;Human;immune modulating agents;in silico;interest;K562 Cells;Kinetics;knock-down;Knock-out;Lead;Leukopenia;Libraries;Luciferases;model building;Molecular;multicatalytic endopeptidase complex;Mutation;Nature;Neutropenia;novel;novel therapeutics;Nucleosomes;NuRD complex;operation;Patients;Pharmaceutical Chemistry;Physicians;Point Mutation;polypeptide;pomalidomide;Positioning Attribute;pre-clinical;protein degradation;Proteins;Proteome;Proteomics;Publishing;recruit;Repression;Research Training;scaffold;Scientist;screening;Sickle Cell Anemia;Sickle Cell Trait;side effect;small hairpin RNA;small molecule;stable cell line;Stains;stem;Structure;Structure-Activity Relationship;Surface Plasmon Resonance;Symptoms;targeted treatment;Techniques;Testing;Thalassemia;Thalidomide;Therapeutic;Thermodynamics;Thrombocytopenia;Titrations;Toxic effect;Training;transcription factor;ubiquitin-protein ligase;Valine;Western Blotting;Work;Zinc Fingers

PROJECT_TITLE: Development of novel fetal hemoglobin inducers using targeted protein degradation


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Cocaine;Drug Abuse (NIDA only);Endocannabinoid System Research;Estrogen;Neurosciences;Stimulant Use and Misuse;Substance Misuse;Women's Health Research

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE Our capacity to manage substance use disorders (SUDs) is hindered by variability within the diagnosed population. One factor that heavily influences relapse risk is biological sex. This proposal centers on identifying the cellular and neural circuit mechanisms through which hormonally mediated reproductive states and co- occurring stress augment relapse vulnerability in females.

PI_NAMEs: HEARING, MATTHEW CARL;MANTSCH, JOHN R. (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Acute;Address;Attenuated;attenuation;Behavior;biological sex;Brain;Cholecystokinin;Chronic;CNR1 gene;Cocaine;cocaine seeking;Corticosterone;Diagnosis;Dose;drug seeking behavior;effective intervention;Endocannabinoids;Estradiol;Estrogen Receptor 2;Estrogen Receptors;Estrogens;experience;Female;Fiber;gamma-Aminobutyric Acid;Genetic;Goals;Gonadal Steroid Hormones;High Prevalence;hippocampal pyramidal neuron;Hormonal;Hormones;improved;in vivo;Incidence;innovation;Interneurons;Intervention;male;Mediating;men;Mus;Nature;neural circuit;Neurobiology;Neurons;Neurosciences;novel;Nucleus Accumbens;Optics;Output;Parvalbumins;Pathway interactions;Pharmaceutical Preparations;Photometry;Physiology;Population;pre-clinical;Predisposition;Prefrontal Cortex;Proestrus;Rattus;receptor;Regulation;Relapse;relapse risk;reproductive;Research;Risk;Role;Sex Differences;Societies;Stress;stressor;Substance Use Disorder;Synapses;Synaptic Transmission;System;Testing;Thalamic structure;Time;transmission process;Treatment outcome;Variant;Woman

PROJECT_TITLE: Estrogen regulation of the prefrontal cortex and drug seeking

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: The mechanisms used by the immune system to control bacterial infections is incompletely understood. We propose that metabolic intermediates, namely aldehydes, are used by the immune system to kill Mycobacterium tuberculosis and possibly other microbial agents. This proposal will identify sources of metabolic aldehydes that can control bacterial growth as well as bacterial pathways that affect susceptibility to aldehydes.

PI_NAMEs: DARWIN, KATERINA HERAN (contact);STANLEY, SARAH A

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: aerobic glycolysis;Affect;aldehyde dehydrogenases;Aldehydes;Animals;Anti-Bacterial Agents;antimicrobial;Antimycobacterial Agents;Appearance;Bacteria;bacterial genetics;Bacterial Infections;Biochemistry;Cells;Cellular biology;Characteristics;Chronic;Clinical Trials;Copper;Data;Development;disabled;Disease;Disulfiram;Drug Metabolic Detoxication;Enzymes;experimental study;FDA approved;fitness;Generations;Genetic;Glyceraldehyde;Glyceraldehyde 3-Phosphate;Goals;Growth;Human;Immune;Immune response;Immune system;Immunity;Immunology;in vivo;Infection;Infection Control;Inflammation;inhibitor;insight;Interferon Type II;Life;Lipid Peroxidation;Lipids;Lung;macromolecule;Macrophage;Malondialdehyde;Mammalian Cell;Metabolic;Metabolism;microbial;Modeling;mouse genetics;mouse model;Mus;mutant;mycobacterial;Mycobacterium tuberculosis;Nitric Oxide;Nitrogen;Nucleic Acids;Outcome;Oxygen;pathogen;Pathway interactions;Phagocytes;Pharmaceutical Preparations;Pharmacotherapy;Predisposition;Production;programs;Proteins;Publishing;Pyruvaldehyde;Reaction;Reactive Oxygen Species;Resistance;Role;Source;Sterility;synergism;Testing;Therapeutic;Tissues;tool;Toxic effect;Tuberculosis;tuberculosis immunity;tuberculosis treatment;Warburg Effect

PROJECT_TITLE: METABOLIC ALDEHYDES AS IMMUNE EFFECTORS AGAINST TUBERCULOSIS

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Lupus;Women's Health Research

ORG_CITY: New York

ORG_NAME: HOSPITAL FOR SPECIAL SURGERY

PHR: PROJECT NARRATIVE These studies will utilize cutting-edge molecular and genetic approaches to dissect the mechanisms controlling the function and differentiation of Age/Autoimmune-associated B cells (ABCs), an emerging B cell subset whose expansion has recently been associated with the development of Systemic Lupus Erythematosus (SLE), a prototypical systemic autoimmune disorder characterized by autoantibody production and multi-organ involvement. Since peripheral expansion of ABC-like cells in SLE correlates with SLEDAI and specific clinical manifestations, in particular lupus nephritis, and since ABCs from SLE patients are the major producers of autoAbs, understanding the molecular mechanisms responsible for their regulation and differentiation will provide critical information into SLE pathogenesis and help uncover novel therapeutic targets.

PI_NAMEs: PERNIS, ALESSANDRA B (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: 2019-nCoV;Affect;African American;Age;Alleles;Anti-viral Response;Autoantibodies;Autoimmune;Autoimmune Diseases;autoimmune pathogenesis;Autoimmunity;B cell differentiation;B-Lymphocyte Subsets;B-Lymphocytes;C57BL/6 Mouse;Cell Lineage;Cell Physiology;Cells;Cellular biology;Characteristics;Child;Clinical;COVID-19 pandemic;cytokine;Data;Development;Disease;early onset;Effector Cell;Endosomes;Epigenetic Process;Estrogens;Exhibits;Family;Family member;Female;Gene Expression Profile;Genes;Genetic;genetic approach;genetic risk factor;genetic signature;Genetic study;genome-wide;Gonadal Steroid Hormones;HIV;Homologous Gene;Human;Immune response;Immunity;immunoregulation;interest;Interferon Type II;Interferons;interleukin-21;ITGAX gene;Knockout Mice;Link;Lupus;Lupus Nephritis;male;Molecular;monocyte;Mus;Mutation;Myelogenous;new therapeutic target;novel;Organ;Pathogenesis;Patients;Peripheral;Phenotype;Plants;Plasma Cells;Plasmablast;Play;Population;Predisposition;Production;Proteins;Regulation;response;restraint;Risk Factors;Role;sex;Sex Bias;Sex Differences;sexual dimorphism;Signal Transduction;Structure of germinal center of lymph node;Susceptibility Gene;Syndrome;System;systemic autoimmune disease;systemic autoimmunity;Systemic Lupus Erythematosus;T-bet protein;Therapeutic;TLR7 gene;Translating;Up-Regulation;vaccination outcome;Virus;Virus Diseases;Woman;X Chromosome;X Inactivation

PROJECT_TITLE: Mechanisms controlling ABC differentiation and function in SLE

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

PHR: Project Narrative Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused over 32 million cases of Coronavirus disease (COVID-19), with greater than 1 million associated deaths to date. Though vaccine trails are ongoing, the correlates of viral clearance and immune protection from SARS-CoV-2 are unknown. This proposal seeks to understand how innate immune signals drive adaptive immunity to SARS-CoV-2, with the goal of identifying fundamental immunologic rules that govern SARS-CoV-2 immunity to promote development of highly effective vaccines.

PI_NAMEs: GOLDMAN-ISRAELOW, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: 1918 influenza pandemic;2019-nCoV;Acute;adaptive immune response;adaptive immunity;Adjuvant;Advisory Committees;Antibodies;Antibody Formation;Antibody titer measurement;B-Lymphocytes;career;career development;cell type;Cells;Cessation of life;Communicable Diseases;Complex;Coronavirus;coronavirus disease;coronavirus vaccine;COVID-19;COVID-19 mortality;cytokine;Data;Dendritic Cells;design;Development;DNA;Doctor of Medicine;Doctor of Philosophy;efficacy evaluation;Etiology;Fellowship Program;Future;Genotype;Goals;Grooming;Hospitals;human coronavirus;Humoral Immunities;Immune;immune activation;Immune response;Immune signaling;Immunity;Immunobiology;Immunoglobulin A;Immunologics;Immunology;immunopathology;improved;Infection;Influenza A virus;Influenza A Virus, H1N1 Subtype;Infrastructure;inhibiting antibody;Innate Immune Response;Innate Immune System;Interferon Type I;Interferons;Internal Medicine;Journals;Kinetics;Knowledge;Laboratories;Lead;Licensing;Location;medical schools;Medicine;Mentors;Mentorship;Methods;Molecular Virology;Morbidity - disease rate;mouse model;Mucosal Immunity;mucosal vaccination;mucosal vaccine;Mucous Membrane;Mus;Natural Immunity;pandemic disease;pandemic response;pathogen;Pathology;Pathway interactions;Pattern recognition receptor;Physicians;Principal Investigator;Production;Productivity;Program Development;Publishing;receptor;Receptor Signaling;Records;Research;Research Personnel;Residencies;Resources;respiratory virus;response;RNA;Role;SARS-CoV-2 immunity;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;Science;Scientist;sensor;Shapes;Signal Transduction;T-Lymphocyte;tool;Training;Training Programs;translational scientist;Vaccination;vaccine development;vaccine trial;Vaccines;Viral;Viral Respiratory Tract Infection;Virus;Virus Diseases;Wild Type Mouse;Work;Writing;ZIKA

PROJECT_TITLE: Innate Control of Adaptive Immunity to SARS-CoV-2

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Chronic Obstructive Pulmonary Disease;Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases

PHR: Project Narrative  Some patients with shortness of breath progress to respiratory failure while others do not. Abnormal gas exchange, respiratory drive, or lung mechanics probably underlie this progression. Using validated tests, I aim to understand why some patients need life support systems and what can be done to prevent it.

PI_NAMEs: MCGUIRE, WILLIAM CAMERON (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Accident and Emergency department;Acute Respiratory Distress Syndrome;Address;Air;Alveolar;Animal Experiments;Brain;Breathing;Cannulas;career;cisterna magna;Clinical;cohort;Cohort Studies;COVID-19 pandemic;COVID-19 patient;Critical Illness;Data;Deterioration;Devices;Dyspnea;Equipment;experience;Gases;high risk;Hospitalization;human data;Impairment;in vivo;Individual;Injections;Intervention;Intubation;Laboratories;Life Support Systems;Literature;Longitudinal Studies;Lung;Lung Diseases;lung injury;lung pressure;Measurement;Mechanical ventilation;Mechanics;Medical;meter;millisecond;murine nodule inducing virus;Nose;novel;Outcome;Oxygen;Oxygen Therapy Care;pandemic disease;Pathogenesis;Pathology;Patient Triage;Patients;Physiological;Physiology;point of care testing;Predictive Value;pressure;prevent;Probability;Productivity;Prognosis;prognostication;progression risk;Randomized, Controlled Trials;Research Design;respiratory;Respiratory Failure;Respiratory Muscles;Respiratory physiology;Risk;Salicylic Acids;SARS-CoV-2 infection;Shortness of Breath;Stress;Structure of parenchyma of lung;supplemental oxygen;Symptoms;Techniques;Testing;theories;Therapeutic;Tidal Volume;tool;Traction;Training;Vaccines;ventilation;Viral Respiratory Tract Infection

PROJECT_TITLE: Physiologic Predictors of Respiratory Failure in Patients Presenting with Dyspnea


NIH_SPENDING_CATS: Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: WASHINGTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative This project will expand upon the ongoing activities of the DC Cohort, a population-level longitudinal cohort of over 10,000 people living with HIV (PLWH) at 15 clinics in Washington, DC. We will 1) enhance the Cohort database to incorporate new data sources to comprehensively describe and monitor HIV and co-occurring conditions; 2) expand the use of the existing DC Cohort Clinical Dashboard to monitor HIV care outcomes as well as key indicators related to ending the HIV epidemic; and 3) use the Cohort as a platform from which to develop pioneering interventions to improve the quality of care of PLWH. The Cohort is an unparalleled clinical, research, and public health resource to assist in monitoring the local response to the HIV epidemic and to generate lessons learned for other urban areas of high HIV prevalence in the US.

PI_NAMEs: CASTEL, AMANDA DERRYCK (contact);MONROE, ANNE KRESS

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: Achievement;Acquired Immunodeficiency Syndrome;Address;age group;Area;Basic Science;Capital;care outcomes;Caring;Cessation of life;Cities;Clinic;Clinical;clinical research site;cohort;Cohort Studies;Collection;Communities;community engagement;comorbidity;Computerized Medical Record;Continuity of Patient Care;dashboard;Data;Data Collection;data dashboard;Data Linkages;data repository;Data Sources;data visualization;Databases;Effectiveness;efficacy evaluation;Electronic Health Record;Enrollment;Epidemic;Epidemiology;epidemiology study;Feedback;Framingham Heart Study;Funding;Future;Geography;Goals;Health;health disparity;Health Resources;High Prevalence;HIV;HIV diagnosis;implementation science;improved;Infrastructure;Intervention;Intervention Studies;Knowledge;Laboratories;Link;Longitudinal cohort;Longitudinal cohort study;Medical;Molecular Epidemiology;Monitor;National Institute of Allergy and Infectious Disease;Newly Diagnosed;novel;novel therapeutics;Outcome;Participant;Patient Outcomes Assessments;Performance;Persons;Pharmacy facility;Population;population based;Positioning Attribute;Prevalence;Prevention;Productivity;Provider;Public Health;Quality of Care;Reduce health disparities;Research;Research Personnel;Research Proposals;Resources;response;Risk;Services;Social Behavior;Testing;Therapeutic;Thinking;Time;tool;transmission process;United States National Institutes of Health;urban area;Viral;Washington;Work

PROJECT_TITLE: The DC Cohort: A Longitudinal Population-Based Cohort Study of People Living with HIV in Washington, DC


ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: Narratives: Stroke remains a leading cause of disability in the United States. Despite recent advances, interventions to reduce damage and enhance recovery after stroke are absent. In this proposal we will investigate a novel drug target “Purinergic receptor P2X4” for the treatment of ischemic stroke in mice. The overall goal of this proposal is to determine if reduction of acute P2X4R response is a viable therapy for stroke in elderly, working towards our long-term goal of developing and identifying target-based therapies for stroke.

PI_NAMEs: VERMA, RAJKUMAR  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acute;acute stroke;Address;Adenosine Triphosphate;Adverse effects;Affect;Age;aged;Aging;Animal Model;animal old age;Animals;antagonist;Anti-Inflammatory Agents;Antiinflammatory Effect;Area;Attenuated;Beds;Biology;Brain;brain cell;Calcium;CCL2 gene;Cell Death;Cell Physiology;Cells;Chronic Phase;Clinic;CX3CL1 gene;cytokine;Data;disability;Disease;effective intervention;efficacy evaluation;efficacy testing;Elderly;Endothelium;Flow Cytometry;Genetic;Goals;Human;human data;Immune;immune activation;Immune response;improved;in vivo;Infiltration;Inflammasome;Inflammation;Inflammatory;inhibitor;Injury;injury recovery;insight;Intervention;ischemic injury;Ischemic Stroke;Knockout Mice;long term recovery;Macrophage;Measures;Mediating;Medical;Membrane;Microglia;Middle Cerebral Artery Occlusion;migration;Modeling;Molecular;monocyte;Mus;Myelogenous;Myeloid Cells;neuroinflammation;neuroprotection;new therapeutic target;novel;novel therapeutics;old mice;Peripheral;Permeability;Phagocytes;pharmacologic;Phase;Play;post stroke;Proteins;Purinoceptor;receptor;receptor expression;Receptor Inhibition;Recovery;Recovery of Function;Research;Resolution;response;Role;Sorting;spatiotemporal;Stroke;stroke outcome;stroke patient;stroke recovery;stroke therapy;Techniques;Testing;Therapeutic;Tissues;tool;treatment duration;United States;uptake;Validation;Vascular Endothelial Cell;Work;young adult

PROJECT_TITLE: Therapeutic implications of purinergic receptor P2X4 in ischemic stroke

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: CAMDEN

ORG_NAME: CORIELL INSTITUTE FOR MEDICAL RESEARCH

PHR: PROJECT NARRATIVE The NHGRI Sample Repository for Human Genetic Research facilitates studies of human genetic and genomic variation by establishing, characterizing and distributing a large and diverse publicly available collection of biospecimens obtained from human populations living around the world, including the prominent 1000 Genomes Project cell line and DNA collection. We propose to continue Coriell’s record of excellence in the management, maintenance and global distribution of this critically important genomic resource, and we are also proposing several new innovations that will increase the value and impact of the resource to ensure that the NHGRI Repository collection remains relevant and meets the growing needs of the scientific community. We plan to further diversify the NHGRI Repository collection with the addition of new sample submissions collected for the Human Pangenome Reference Consortium, and the development of an unprecedented collection of induced pluripotent stem cells that will include a wide range of human genomic diversity.

PI_NAMEs: SCHEINFELDT, LAURA  (contact)

PROGRAM_OFFICER_NAME: ARGUELLO, ALEXANDER

PROJECT_TERMS: Acceleration;Adherence;biobank;Biocompatible Materials;Biological;Biomedical Research;Catalogs;Cell Line;cell repository;Cells;Collection;Communities;Consent;Country;Custom;Data;data repository;Databases;Development;Diagnosis;DNA;Education;Educational process of instructing;Ensure;Equipment and supply inventories;Event;experience;Genetic;Genetic Diseases;Genetic Research;Genetic Variation;Genome;genome resource;genomic variation;Genomics;Goals;Growth;Human;human disease;Human Genetics;human pangenome;improved;induced pluripotent stem cell;Infrastructure;innovation;International;Maintenance;Medical Research;member;Mission;Molecular Weight;National Human Genome Research Institute;operation;outreach;Population;Preparation;Prevention;public repository;Qualifying;Recording of previous events;Reporting;repository;Reproducibility;Research;Research Personnel;research study;Resource Development;Resources;RNA;Sampling;Secure;Surveys;Suspensions;symposium;Technology;Third Generation Sequencing;Trust;United States National Institutes of Health;web site;Work

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Data Science;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Relevance Successful completion of the proposed project will increase the usability and accuracy of our publicly available segmentation tools, and open up new possibilities, such as integrating them into the MRI scanner and rapidly detecting Alzheimer’s-related changes. These new capabilities well enable other studies to significantly increase their ability to detect AD and other disease effects in research settings as well as phase II and phase III clinical trials due to the radical increase in speed of the new tools, enabling them to be applied to a diverse set of MRI contrasts and much larger datasets, rapidly and accurately. Further, they will allow rapid application of cutting-edge analyses to the ongoing Alzheimer’s Disease NeuroImaging Initiative dataset, improving the ability to extract early biomarkers of this devastating disease.

PI_NAMEs: FISCHL, BRUCE  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Aging;Algorithms;Alzheimer disease detection;Alzheimer's Disease;Anatomy;automated segmentation;Brain;Chemicals;Code;Communities;convolutional neural network;cranium;Data;Data Set;deep learning;deep learning algorithm;Diagnosis;Disease;Documentation;early detection biomarkers;efficacy evaluation;Engineering;Ensure;Excision;flexibility;Functional Magnetic Resonance Imaging;Future;Generations;high resolution imaging;Hour;Human;human disease;Image;improved;Infrastructure;Label;large datasets;Licensing;Magnetic Resonance Imaging;Manuals;Measures;Memory;Modeling;morphometry;Nervous System Disorder;Neuroanatomy;Neurobiology;neuroimaging;novel;open source;open source tool;Pattern;Phase;Phase III Clinical Trials;Physiology;Population;prevent;Procedures;prototype;Publishing;Qualifying;rapid detection;Recording of previous events;Reproducibility;Research;Research Personnel;Resolution;Resources;Rest;Sensitivity and Specificity;skills;spatial relationship;Speed;Staging;Stream;Structure;support tools;Surface;System;Technology;Test Result;Testing;Therapeutic Intervention;Time;tool;Training;usability;Validation;Variant;web site;wiki;Work

PROJECT_TITLE: Deep Learning Algorithms for FreeSurfer

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Neurosciences;Pain Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Acid-sensing ion channels (ASICs) sense extracellular pH and are potential drug targets for stroke, neurodegenerative disorders and pain. Our long-term goal is to understand the molecular mechanisms for ASIC function both at the structural level as well as cellular level. This will help us understand how ASICs contribute to electrical excitability in a diverse array of neurons as well as how to design therapies that target these important molecules.

PI_NAMEs: BANKSTON, JOHN  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: ASIC channel;Binding;Binding Sites;Cells;Central Nervous System;Complex;Data;desensitization;Distal;Drug Targeting;Electrophysiology (science);Event;extracellular;Family;Fluorescence;Fluorescence Resonance Energy Transfer;fluorophore;Goals;Homo;insight;interest;Ion Channel;Ions;Ischemia;Length;Macromolecular Complexes;Measures;member;Modeling;Molecular;Molecular Conformation;Neurodegenerative Disorders;Neurons;Pain;Pain management;patch clamp;Peripheral Nervous System;Prevalence;Property;Protein Family;Protein Isoforms;Proteins;Protons;receptor;Regulation;Research;sensor;Sodium;stoichiometry;Stroke;System;targeted treatment;Techniques;therapy design;Transition Elements;Transmembrane Domain;Work

PROJECT_TITLE: Dynamics of Acid-sensing ion channels

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


NIH_SPENDING_CATS: Genetics;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PI_NAMEs: TIDBALL, JAMES G (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Ablation;Acute;Adult;Affect;Appearance;Biological;Biological Assay;Cell Count;Cell Differentiation process;Cell Physiology;Cell Proliferation;Cells;Cessation of life;Complex;conditional mutant;daughter cell;Defect;Development;Differentiation and Growth;Disease;Enzymes;experimental study;fetal;Gene Activation;Gene Expression;Gene Modified;Genes;Growth;Health;histone demethylase;histone methylation;Histones;In Vitro;in vivo;injured;Injury;insight;Investigation;klotho protein;Knowledge;Learning;Life;life span;Lysine;Mediating;Methylation;Modeling;Molecular;Mus;Muscle;Muscle Development;Muscle Fibers;Muscle function;muscle regeneration;Muscle satellite cell;Mutation;myogenesis;Myopathy;Natural regeneration;neonatal mice;novel;Outcome;Pathologic;Pathway interactions;Perinatal;Play;Population;postnatal;postnatal development;prevent;programs;regeneration following injury;Regenerative capacity;Research Personnel;response;Role;Signal Transduction;Skeletal Muscle;stem cells;Surface;Testing;Transgenes;Transgenic Organisms;WNT Signaling Pathway;Work

PROJECT_TITLE: Novel mechanisms regulating muscle growth and regeneration: elucidating the Klotho/Jmjd3/Wnt axis

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: WALTHAM

ORG_DEPT: BIOLOGY

ORG_NAME: BRANDEIS UNIVERSITY

PHR: NARRATIVE This proposal addresses the mechanisms by which cells coordinate two of their major cytoskeletal polymer systems, septins and actin, to promote intracellular transport and cell morphogenesis. Elucidating these mechanisms will advance our basic understanding of fundamental, conserved biological processes mediated by septins and actin, and how they go awry in a broad array of human disease states caused by mutations in actin, septins, and their regulatory proteins, including cardiovascular disease, renal and immune disorders, cancer, deafness, and autosomal dominant neurological disorder Hereditary Neuralgic Amyotrophy (HNA).

PI_NAMEs: MAGLIOZZI, JOSEPH O (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Actins;Acute;Address;Affect;Affinity;Architecture;autosome;Binding;Biological Assay;Biological Process;Bundling;C-terminal;Cardiovascular Diseases;cell growth;Cell Physiology;Cells;Collaborations;Complex;copolymer;Cytokinesis;Cytoskeleton;Data;deafness;design;experimental study;F-Actin;Filament;Foundations;Future;Genetic;genetic regulatory protein;Goals;Hereditary Neuralgic Amyotrophy;Higher Order Chromatin Structure;Human;human disease;Image;imaging approach;Immune System Diseases;In Vitro;in vivo;in vivo evaluation;inhibitor;insight;Intracellular Transport;Kidney Diseases;Knowledge;Label;Length;Ligands;Link;live cell imaging;Malignant Neoplasms;Mediating;Microfilaments;Mitotic;model organism;Modeling;Molecular;molecular imaging;Morphogenesis;Mutagenesis;mutant;Mutation;Myosin Light Chains;Neck;Nervous System Disorder;novel;Organism;polarized cell;Polymers;Property;Proteins;reconstitution;recruit;Regulation;Role;Saccharomyces cerevisiae;Saccharomycetales;scaffold;Secretory Vesicles;Sedimentation process;Shapes;single molecule;Site;Structure;superresolution microscopy;System;Testing;Total Internal Reflection Fluorescent;Training;Vesicle;Work;Yeasts

PROJECT_TITLE: Mechanisms of septin-actin cytoskeletal crosstalk

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Endocrine Disruptors;Heart Disease;Heart Disease - Coronary Heart Disease;Pediatric

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

PHR: Project Narrative: Phthalate plasticizer exposure is prolific in clinical settings, with toxicity reported in many organ systems including the heart. Neonates and infants undergoing cardiopulmonary bypass have increased exposure to phthalate plasticizers through multiple medical interventions. This project will investigate the direct effects of phthalate plasticizers on human cardiac physiology, while also assessing whether alternative biomaterials or mitigation strategies can decrease phthalate exposure and improve health outcomes.

PI_NAMEs: GUERRELLI, DEVON  (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: 1 year old;Address;Adopted;Age;Arrhythmia;Biocompatible Materials;Blood;blood product;Body System;boys;Bypass;Calcium;Calcium Signaling;Cannulas;Cardiac;Cardiac Electrophysiologic Techniques;Cardiac health;Cardiac Myocytes;Cardiac Surgery procedures;Cardiology;Cardiopulmonary Bypass;Cardiotoxicity;Cardiovascular Physiology;Cells;Chemical Exposure;Chemicals;Childhood;Clinical;clinically relevant;Confocal Microscopy;Data;Decision Making;Development;Devices;Diethylhexyl Phthalate;efficacy evaluation;endotracheal;experience;Exposure to;flexibility;Fresh Frozen Plasmas;Future;Gap Junctions;Goals;Health;Heart;high risk;Human;Impairment;improved;Infant;insight;intercellular communication;Intervention;Laboratory Research;Liquid substance;Low Cardiac Output;manufacture;Manufacturer;Maps;Medical;Medical Device;Methodology;Methods;Microelectrodes;Modeling;mono-(2-ethylhexyl)phthalate;Myocardium;Neonatal;neonate;Optics;Outcome;Patients;Pediatric Hospitals;pediatric patients;Perioperative;phthalates;Physiological;Physiology;Plasticizers;Plastics;Polyvinyl Chloride;Postoperative Period;Pre-Clinical Model;Preparation;Prevalence;Procedures;Recommendation;Reporting;Reproductive Health;Research Project Grants;response;Risk;Safety;stem cells;Technical Expertise;Techniques;Tissues;Toxic effect;Training;Translational Research;Tube;United States;United States Food and Drug Administration;Weight;Whole Blood

PROJECT_TITLE: Plastic Chemicals in Pediatric Cardiopulmonary Bypass: Evaluating Cardiac Toxicity and Investigating Clinical Alternatives


NIH_SPENDING_CATS: Aging;Atherosclerosis;Bioengineering;Biotechnology;Cardiovascular;Gene Therapy;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Nanotechnology

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Atherosclerotic cardiovascular diseases (ASCVDs) represent a major public health crisis in our Nation. This research proposal aims to test a novel anti-atherosclerotic nano-therapy to treat the underlying causes of atherosclerotic plaque formation, while protecting the vascular endothelium. Successful completion of this research will lead to the development of a first of its kind anti-atherosclerotic therapeutic that will result in a paradigm shift in how ASCVDs are treated.

PI_NAMEs: HETHERINGTON, ISABELLA  (contact)

PROJECT_TERMS: 5' Untranslated Regions;Adverse effects;Anti-Inflammatory Agents;Apolipoprotein E;Arterial Fatty Streak;Arteries;Atherosclerosis;Binding Sites;Cardiac;career;Cause of Death;cell assembly;Cell Cycle;cell motility;Cell Physiology;Cell Proliferation;Cell Separation;cell type;Cells;Chronic;Clinical Trials;clinically relevant;Colchicine;college;comparison control;Control Groups;Coronary artery;cytokine;Deposition;design;Development;Disease;Dose;Effectiveness;effectiveness testing;efficacy testing;Endothelial Cells;Endothelium;Environment;Event;experimental study;feasibility testing;Generations;Goals;healing;Health;Heart;Human;hypercholesterolemia;Hypertension;In Vitro;in vivo;Incidence;Infection;Inflammasome;Inflammation;Inflammatory;Inhibition of Cell Proliferation;inhibitor;Injury;innovation;Institution;Interleukin-1 beta;Lipids;Macrophage;Medicine;Mentors;Mentorship;Messenger RNA;Methods;MicroRNAs;migration;Modeling;mortality risk;mouse model;Mus;nanoparticle;nanoparticle delivery;nanotherapy;neointima formation;novel;novel therapeutics;Outcome;overexpression;Patients;Penetration;Peptides;percutaneous coronary intervention;Pharmaceutical Preparations;Postdoctoral Fellow;preservation;Principal Investigator;Procedures;Proliferating;Public Health;Reporting;Research;Research Proposals;Resolution;Resources;Risk Factors;selective expression;self assembly;Series;Site;Small Interfering RNA;Smooth Muscle Myocytes;Stenosis;stent thrombosis;Stents;Targeted Research;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Research;therapeutic RNA;Thrombosis;Training;Transfection;United States;Vascular Endothelium;Vascular Smooth Muscle;Work

PROJECT_TITLE: Development of a novel site-and cell-selective mRNA therapeutic to treat atherosclerosis


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention;Sleep Research

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE The loss of sleep's neuroprotective properties is a major risk factor for the development of Alzheimer's disease, and recent reports suggest that measuring age-related changes in sleep activity may indicate risk of Alzheimer's disease and identify potential targets for novel Alzheimer's disease therapies. Our preliminary data suggest that components of sleep's role in memory processing — termed theta bursts — indicate risk of cognitive decline among aging adults and may be a key connection between sleep and Alzheimer's Disease. Here, we propose to further investigate relationships between changes in theta burst activity during sleep's memory processing and cognitive changes among aging adults.

PI_NAMEs: MCCONNELL, BRICE V (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: Adult;Age;age related changes;Age-associated memory impairment;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer's disease therapy;Alzheimer’s disease biomarker;American;Biological Markers;biomarker development;Brain;Cause of Death;Clinical;Cognition;Cognitive;Cognitive aging;cognitive change;cognitive performance;Communication;Data;Data Set;Dementia;Deterioration;Development;Early Diagnosis;Electroencephalography;Elements;Etiology;Event;experience;experimental study;follow-up;Foundations;Future;Goals;Hippocampus;Home;Homeostasis;Impaired cognition;improved;innovation;Intervention;Knowledge;Measures;Memory;memory consolidation;memory process;Methodology;Methods;Modeling;Monitor;Neurodegenerative Disorders;neuronal patterning;Neurons;neurophysiology;neuroprotection;new therapeutic target;novel;novel diagnostics;Pathogenesis;Pattern;Physiological;Physiology;Pre-Clinical Model;predictive marker;Prevalence;Process;Property;Regression Analysis;Regulation;Reporting;Research;restoration;Risk;Risk Factors;Role;screening;Sleep;Sleep Deprivation;Sleep disturbances;sleep spindle;Slow-Wave Sleep;Surface;Synapses;Testing;tool;treatment response;Visit;wearable device

PROJECT_TITLE: A Breakdown of Memory Replay: Elucidating the Relationship Between Sleep and Alzheimer's Disease from Surface Electroencephalography

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: GEORGETOWN UNIVERSITY

PHR: PROPOSAL NARRATIVE The challenge with treating pediatric brain tumors is how to have an effective but safe treatment. We are focusing on a protein termed Brd4, which is a target in pediatric cancer. Our studies will determine the pathways and developmental times when it is possible to disrupt Brd4 without affecting brain development.

PI_NAMEs: AYAD, NAGI G (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Activity Cycles;Affect;Ataxia;Behavioral;Binding;Biology;Brain;Breeding;casein kinase;casein kinase II;Cell Cycle;Cell Cycle Progression;Cell Proliferation;Cells;Cerebellar Ataxia;Cerebellum;chemotherapy;Childhood Brain Neoplasm;Chromatin;clinical development;Clinical Trials;Cognitive deficits;Cytoplasmic Granules;Defect;Development;Down-Regulation;Epigenetic Process;Essential Genes;gain of function;Gene Expression;granule cell;Growth;In Vitro;in vivo;inhibitor;insight;Knock-out;Knockout Mice;Malignant Childhood Neoplasm;Malignant Neoplasms;Medulloblastoma;mouse model;Mus;mutant;N-terminal;nerve stem cell;Neuronal Differentiation;Neurons;novel therapeutics;Operative Surgical Procedures;Pathway interactions;Patients;Phosphorylation;Phosphotransferases;Plague;Process;progenitor;Proliferating;Proteins;Reader;Regulation;Resistance;Role;Series;SHH gene;Signal Pathway;small molecule;Sonic Hedgehog Pathway;standard of care;stem cell division;stem cell proliferation;stem cells;Testing;Time;Transcript;transcriptome sequencing;tumor growth;Up-Regulation;upstream kinase;Work

PROJECT_TITLE: Epigenetic pathways and cell cycle exit

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Neurosciences;Rare Diseases;Regenerative Medicine

ORG_CITY: COLUMBIA

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: PROJECT NARRATIVE Hyposalivation is directly associated with radiation therapy, which is administered every year to approximately 60,000 head and neck cancer patients in the United States. Hyposalivation contributes to oral microbial infections and impairs activities of daily living (e.g., speaking, chewing, and swallowing) and current treatments for this condition are limited to medications that induce saliva secretion from residual acinar cells and the use of saliva substitutes. However, given that these therapies target relatively surface-level symptoms and provide only temporary relief, development of alternative treatments to restore gland function is essential. This project aims to design a scaffold (consisting of fibrin hydrogels linked to basement proteins and growth factors) and apply it into damaged salivary glands (with the aim of forming new tissue and recovering lost secretory function).

PI_NAMEs: ANDREADIS, STELIOS THEOHARIS;BAKER, OLGA JULIANA (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: 3-Dimensional;Acinar Cell;Activities of Daily Living;Address;alternative treatment;American Cancer Society;Blocking Antibodies;Blood Vessels;cell assembly;cell motility;Cell Proliferation;Cell Separation;Cell Survival;Cell-Matrix Junction;Cells;Conditioned Culture Media;crosslink;Deglutition;design;Development;Effectiveness;Epithelium;FGF10 gene;Fibrin;fibroblast growth factor 9;Food;Fortification;Gland;Growth Factor;Hair follicle structure;Head and Neck Cancer;head and neck cancer patient;Head and neck structure;Human;hydrogel scaffold;Hydrogels;Immobilization;Impairment;improved;In Vitro;in vivo;Infection;irradiation;keratinocyte growth factor;laminin-1;Light;Link;Maintenance;Mastication;Measures;Mesenchymal Stem Cells;Methods;microbial;migration;Morphogenesis;mouse model;Mus;Natural regeneration;Nerve;nerve supply;neurotrophic factor;Oral;oral mucositis;particle;Pathway interactions;Patients;Peptides;Persons;Pharmaceutical Preparations;Physiology;polymerization;Polymers;preservation;Production;Proliferating;Proteins;Radiation therapy;Recombinant Fusion Proteins;Recovery of Function;Residual state;response;Saliva;saliva secretion;Salivary;Salivary Glands;scaffold;Secretory Vesicles;Signal Transduction;Speech;spheroids;Structure;Surface;Swelling;Symptoms;System;targeted treatment;Taste Perception;Therapeutic Intervention;Tight Junctions;Tissues;tyrosyl-isoleucyl-glycyl-seryl-arginine;United States;Vascular Endothelial Growth Factors;Vascularization;Water;Work;wound healing;Xerostomia

PROJECT_TITLE: THE USE OF FIBRIN HYDROGELS TO PROMOTE SALIVARY GLAND REGENERATION


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Atrial Fibrillation (AF) is the most common arrhythmia affecting 46 million people globally. More relevant in vitro models of the condition are needed to identify novel preventative therapeutic targets to curtail the steady increase in prevalence. Our human induced pluripotent stem cell derived atrial cardiomyocytes, cardiac fibroblasts, and decellularized extracellular matrix based engineered heart tissue incorporated into our collaborator’s Cell-in-Gel platform has promising potential to accurately recapitulate AF development and allow us to elucidate the mechanisms underpinnings afterload-induced AF.

PI_NAMEs: DILORETTO, DAPHNE AGOSTINA (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: 3-Dimensional;Action Potentials;Address;Adhesions;Adult;Affect;Animal Model;Anti-Arrhythmia Agents;Anticoagulants;Arrhythmia;Atrial Fibrillation;Biochemical;Biomedical Engineering;Cardiac;Cardiac Myocytes;cardiac tissue engineering;Cell Line;Cell model;Cells;Chronic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;comorbidity;Complex;CRISPR/Cas technology;Cues;Dangerousness;Development;Diabetes Mellitus;Electrophysiology (science);embryonic stem cell;experimental study;Extracellular Matrix;Fibroblasts;Fibrosis;Gel;Gene Silencing;Generations;Goals;graduate student;Heart;Heart Atrium;Heart failure;Heterogeneity;Human;Human Engineering;human induced pluripotent stem cells;human model;human pluripotent stem cell;Hypertension;Image;improved;in vitro Model;induced pluripotent stem cell;Inflammasome;Inflammation;insight;Knowledge;mechanical load;mechanical signal;Mechanical Stress;Mediating;Mentors;Mentorship;Modeling;Morphology;multidisciplinary;Myocardial;Myocardial Ischemia;Myocardium;Nature;novel;Obesity;Outcome;Pathway interactions;Patients;Persons;Physicians;Physiologic intraventricular pressure;Physiological;Physiology;Play;Polyvinyl Alcohol;polyvinyl alcohol hydrogel;Predisposition;pressure;Prevalence;prevent;Prevention strategy;Profibrotic signal;Rattus;Research;Risk;Role;Scientist;side effect;Stress;Stretching;Structure;Techniques;Testing;therapeutic target;three dimensional cell culture;thromboembolic stroke;Thrombosis;Tissue Engineering;Tissues;Training;Work

PROJECT_TITLE: Mechanisms Underpinning Afterload-Induced Atrial Fibrillation