ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project narrative The endoplasmic reticulum is a ubiquitous cellular organelle that plays a central role in lipid metabolism. The three projects in this proposal investigate how cells generate and regulate subdomains within the endoplasmic reticulum that maintain cellular lipid homeostasis. Gaining insight into these processes is critical for understanding how defects in them contribute to several disease states, particularly obesity, type 2 diabetes, and atherosclerosis.

PI_NAMEs: PRINZ, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Address;Atherosclerosis;Biogenesis;biological adaptation to stress;Biological Assay;Carrier Proteins;Cell Physiology;Cells;Defect;Disease;disease-causing mutation;Endoplasmic Reticulum;Family;Genetic Screening;Homeostasis;Hydrophobicity;In Vitro;insight;interdisciplinary approach;Knowledge;lipid metabolism;lipid transport;Lipids;Membrane;Mitochondria;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Organelles;Oxidative Stress;Play;Process;Proteins;response;Role;Signal Transduction;Site;Stress;Tube;Ubiquinone

PROJECT_TITLE: Roles of endoplasmic reticulum subdomains in regulating intracellular lipid distribution and organelle biogenesis

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Public Health Relevance: Investigations will be undertaken on the conformational properties of biological macromolecules, including RNA, carbohydrates, and proteins to relate their structural and dynamical properties to their biological functions. Efforts will include the development of improved mathematical models and methods for computational modeling of macromolecules and small, drug-like molecules. These tools will be applied to facilitate our understanding of immune response and for the development of novel therapies for diseases targeting infectious disease and cancer.

PI_NAMEs: MACKERELL, ALEXANDER D (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Amaze;Amino Acids;Antibodies;Binding;Biological;Biological Process;biological systems;Carbohydrates;Chemicals;Communicable Diseases;Computer Models;deep neural network;Dependence;Development;Disease;drug discovery;drug-like compound;Equilibrium;Exhibits;Freedom;Generations;Glycoproteins;Heterogeneity;Immune response;improved;Investigation;Ions;Laboratories;Ligand Binding;Ligands;macromolecule;Malignant Neoplasms;mathematical methods;mathematical model;method development;Methods;Molecular Conformation;molecular dynamics;novel;novel therapeutics;Nucleic Acids;Oligonucleotides;Peptides;Pharmaceutical Preparations;Phosphorylation;Polysaccharides;programs;Property;Proteins;public health relevance;Reaction;receptor;Research;RNA;RNA Folding;Role;Sampling;Signal Transduction;simulation;Site;solute;Structure-Activity Relationship;System;Therapeutic;tool;Water;Work

STUDY_SECTION: MRAE

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - E Study Section[MRAE]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: ATHENS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: PROJECT NARRATIVE The goal of the proposed work is to understand the molecular underpinnings of fundamental metabolic and physiologic processes in microbial cells, especially in human pathogens, with the goal of providing potential therapeutic targets to treat human disease.

PI_NAMEs: ESCALANTE, JORGE C (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Affect;Anabolism;Biochemical;Biochemical Pathway;Bioinformatics;Cell membrane;Cells;Chemicals;cobamamide;Coenzymes;Collaborations;Complement;Complex;Enzymes;Epigenetic Process;Equilibrium;Event;flexibility;Generations;Genes;Genetic;genetic regulatory protein;Goals;Health;Human;human disease;human pathogen;Infection;innovation;insight;interest;iron metabolism;Laboratories;Liposomes;Membrane;Metabolic;Metabolism;Methodology;Microbe;microbial;Microscopy;Mission;Modeling;Molecular;Molecular Biology;Molecular Structure;Multienzyme Complexes;Oxidative Phosphorylation;Pathogenesis;Pathway interactions;Physiological;Physiological Processes;Polymers;Process;Prokaryotic Cells;protein function;Proteins;Research;Salmonella;Salmonella infections;Testing;therapeutic target;transcription factor;United States National Institutes of Health;Visualization;Work

PROJECT_TITLE: Analysis of the Metabolic Capabilities of Prokaryotic Cells

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Natural Products

ORG_CITY: NEW HAVEN

ORG_DEPT: CHEMISTRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative We wish to continue our development of new paradigms for the selective synthesis of complex bioactive molecules. Progress in this field enables efficient syntheses of candidates for new medicines, and eventually of the new drugs themselves. A particular emphasis involves catalysis in complex molecular environments, which is a next-generation challenge in synthetic and medicinal chemistry.

PI_NAMEs: MILLER, SCOTT J (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Site-Selective Catalysis for Bioactive Scaffold Diversification


ADMINISTERING_IC: TR

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

ORG_CITY: WINSTON-SALEM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATVE This Academic Learning Health System Scholars Program (aLHSSP) will provide the next generation of translational scientists with the methodologic and professional skills to a) conduct rigorous research in the complex environments of health systems, and b) disseminate and implement findings from such research into practice. The aLHSSP will offer a postdoctoral training experience that will lead to a Master of Science in Learning Health System Science; Scholars will also conduct a mentored research project that addresses a pressing health system issue. They will be guided by teams of experienced and committed faculty who are subject-matter experts and well-grounded in the principles of effective mentoring.

PI_NAMEs: HOUSTON, THOMAS K;TOOZE, JANET A. (contact)

PROGRAM_OFFICER_NAME: CONROY, JENNIE LYNN

PROJECT_TERMS: Postdoctoral Fellow

PROJECT_TITLE: CTSA Postdoctoral T32 at Wake Forest

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 CI-7 (01)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research;Health Services

PHR: Project Narrative The Wake Forest (WF) Clinical and Translational Science Institute (CTSI) K12 Program is a component of the WF CTSI and shares its overall vision of catalyzing our health system’s transformation into an exemplary Learning Health System. To develop a highly trained workforce of scientists prepared to accomplish this vision, the CTSI K12 Program will provide a rigorous training and team mentoring program for outstanding early-career faculty with a focus on 1) promoting a deep understanding of the translational science process; 2) developing expertise in the eight learning health system science competencies central to an Academic Learning Health System; and 3) continuing to expand on the strengths of our CTSI KL2 Program and of our collaborations with other CTSA hubs to exchange learning experiences and share highly successful training models.

PI_NAMEs: ALLRED, NICHOLETTE D. (contact)

PROGRAM_OFFICER_NAME: GOPAL-SRIVASTAVA, RASHMI

PROJECT_TERMS: Award;care delivery;career;Caring;Clinical;Clinical Sciences;cohort;Communities;Competence;Data;Development;Development Plans;Dimensions;E-learning;early-career faculty;Education;education research;education resources;Educational Curriculum;Educational Status;Elements;Eligibility Determination;Evaluation;evidence base;Funding;Goals;health equity promotion;Health system;Healthcare Systems;Individual;Institution;International;Intervention;Laboratories;Learning;Manuscripts;Mentored Clinical Scientist Development Program;Mentorship;National Center for Advancing Translational Sciences;novel;Patients;Policies;pre-clinical;Process;programs;Publishing;recruit;response;Scholarship;Science;Scientist;Site;System;Teacher Professional Development;Testing;tool;Training;Training Programs;trait;translational pipeline;Translational Research;translational scientist;Translations;United States Agency for Healthcare Research and Quality;Vision;Wages;Work

PROJECT_TITLE: CTSA K12 Program at Wake Forest


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Stanford CTSA's Mentored Research Career Development Program (K12) will train the next generation of translational Scholars in biomedical research. The program emphasizes practical, individualized training tailored to the Scholars and focuses on community engagement, informatics, and rigor and reproducibility, and the new science of translation to ensure translated products truly benefit patients from all walks of life. Our accomplished faculty are committed to mentoring Scholars across disciplines and translational stages and building on a 15-year history of diverse scholars who have gone on to independent research funding and leadership roles.

PI_NAMEs: ASCH, STEVEN M. (contact);LINOS, ELENI

PROGRAM_OFFICER_NAME: ATIENZA, AUDIE A

PROJECT_TERMS: Acceleration;analytical method;Area;Award;Biomedical Research;career;career development;Characteristics;Clinical Research;Communities;community advisory board;community engagement;Creativeness;design;Development;digital health;Ecosystem;Education;Ensure;Evaluation;experience;Faculty;Funding;improved;Informatics;innovation;instructor;Investments;Leadership;lectures;Mentored Clinical Scientist Development Program;Mentors;Mentorship;next generation;Outcome;Patients;peer coaching;Philosophy;pragmatic implementation;Program Development;programs;Publications;Recording of previous events;recruit;Reproducibility;Research;Research Project Grants;Rest;Scientist;Silicon;skills;Societies;Structure;success;Training;Training Programs;Translating;translational pipeline;Translational Research;translational scientist

PROJECT_TITLE: CTSA K12 Program at Stanford


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Social Determinants of Health

PHR: PROJECT NARRATIVE The Wake Forest Clinical and Translational Science Institute (CTSI) seeks to create a model for advancing translational science in a large academic health system with activities grounded in a culture of accountability for enhancing diversity, equity, and inclusion. Development of such a model would have great impact on human health given the rapid consolidation of academic and non-academic health systems in the United States and the challenges in conducting research in busy practice settings. Overcoming roadblocks and challenges associated with translational science in environments of the size and scope of large medical centers will greatly accelerate the development of effective techniques for the prevention and treatment of disease.

PI_NAMEs: ARD, JAMY D;FOLEY, KRISTIE L;ROSENTHAL, GARY E (contact)

PROJECT_TERMS: Acceleration;Accident and Emergency department;Accountability;Achievement;Address;Adoption;Advocate;Ambulatory Surgical Procedures;behavioral health;Biological Models;care delivery;Caring;Child;Clinic;Clinical effectiveness;Clinical Sciences;clinical translation;Collaborations;Communities;community setting;Data;Development;Disease;disparity reduction;Dissemination and Implementation;Education;Educational process of instructing;electronic health data;Electronic Health Record;Elements;Emergency Situation;Environment;equity, diversity, and inclusion;Evidence based practice;experience;Extramural Activities;Funding;Goals;Growth;Health;health care disparity;Health care facility;health care settings;health equity;Health system;Hospitals;Human;improved;Incentives;Informatics;innovation;Integrated Health Care Systems;Knowledge;Learning;Link;Medical center;medical specialties;Methods;Midwestern United States;Mission;Modeling;North Carolina;novel;novel therapeutics;Patient Recruitments;Patients;Pilot Projects;population survey;practice setting;pragmatic study;Prevention;Primary Care;Process;programs;Reaction Time;recruit;Reduce health disparities;Rehabilitation therapy;Research;Research Design;Resources;Respondent;safety net;Sampling;Scholarship;Science;Service delivery model;Site;social health determinants;Source;Structure;System;systems research;Techniques;Testing;Training;Translational Research;Translations;United States;Vision;Work

PROJECT_TITLE: CTSA UM1 Program at Wake Forest

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 CI-9 (01)]


ORG_DEPT: PEDIATRICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative The mission of the Johns Hopkins University (JHU) Institute for Clinical and Translational Research (ICTR) Predoctoral Clinical Research Training Program (T32) is to provide an integrated set of training opportunities focused on the core principles of translational science. Our partnerships with MSU, a Historically Black University (HBU), and UMB will provide additional access to diverse perspectives to help address health disparities. The program offers trainees intensive and hand-on learning experiences that prepare them to be exemplary clinical and translational scientists in any discipline, specialty or subspecialty.

PI_NAMEs: ATKINSON, MEREDITH ANN (contact)

PROGRAM_OFFICER_NAME: DIBELLO, ANTHONY THOMAS

PROJECT_TERMS: pre-doctoral

PROJECT_TITLE: CTSA Predoctoral T32 at Johns Hopkins


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative The Emory University Clinical Research Center will carry out the mission of the Pediatric Heart Network to improve health outcomes in patients with pediatric acquired and pediatric and adult congenital heart disease (CHD). This will be achieved by supporting research trials in these populations and communicating the findings to patients, families, and care providers.

PI_NAMEs: BOOK, WENDY M.;KOCHILAS, LAZAROS K.;MAHLE, WILLIAM T (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: Address;Adult;Affect;Agreement;Area;Budgets;Cardiac;care providers;Caring;Categories;Child;Child Care;Child Health;Child health care;Childhood;Clinical;Clinical and Translational Science Awards;Clinical Research;Clinical Trials;Clinical Trials Network;Collaborations;Communication;Communities;Conduct Clinical Trials;congenital heart abnormality;Congenital Heart Defects;Data;Data Analyses;Data Coordinating Center;data dissemination;data submission;Databases;Dedications;Development;Disease;Enrollment;Ensure;Evaluation;Evidence Based Medicine;experience;Faculty;Family;Gender;Goals;Health;Heart;Heart Diseases;Human Resources;improved;Individual;Information Dissemination;Informed Consent;Infrastructure;innovation;Institutional Review Boards;Intervention;Investigational Drugs;Lead;Leadership;life span;Medical;medical schools;meetings;Methodology;Minority;Mission;Monitor;Multicenter Studies;National Heart, Lung, and Blood Institute;novel;Nurses;Operative Surgical Procedures;Outcome;Outcome Measure;Participant;patient retention;Patients;pediatric department;Performance;Pharmaceutical Services;Population;Population Heterogeneity;programs;Protocols documentation;Quality of life;Recording of previous events;recruit;Registries;Research;Research Design;Research Personnel;Research Support;Resolution;Resources;Site;skills;Standardization;Structure;success;Techniques;Training;Universities;Work;Writing

PROJECT_TITLE: Pediatric Heart Network Emory University

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-Q (O2)]


NIH_SPENDING_CATS: Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE The goal of this proposal is to benefit health through the creation of a center (the Hub) that will catalyze new research, training, and community outreach. Our first theme, From Lab To Life, highlights our focus on accelerating the translation of basic biomedical discovery to possible clinical application. Our second theme, From Hub to Health, reflects our strategy to ensure that Hub innovations are effectively implemented to actually improve public health and reduce health disparities and inequities in our community, our region, and across the nation.

PI_NAMEs: COOPER, DAN M;VILAIN, ERIC J. (contact)

PROGRAM_OFFICER_NAME: MERCHANT, CAROL

PROJECT_TERMS: Acceleration;acronyms;Address;African;Asian Americans;Award;Black race;care systems;Caribbean region;Cells;Clinical;clinical application;Clinical Research;Clinical Sciences;clinical translation;Clinical Trials;Collaborations;Communities;community collaboration;Community Developments;community engagement;Community Outreach;community partners;Complex;County;Data;Data Science;design;Diagnostic;Discipline;Disease;Disparity;Dissemination and Implementation;diversity and inclusion;Education;Education and Outreach;Elements;Ensure;Environment;equity, diversity, and inclusion;Ethnic Origin;Faculty;flexibility;Flowers;Funding;Goals;Growth;haptics;Health;Health Benefit;health care availability;health care disparity;health data;health disparity;health inequalities;Health Sciences;Health Services;Healthcare;higher education;Hispanic;implementation science;improved;Inequity;Informatics;innovation;Inpatients;insight;Institution;Joints;Latino;Lead;Leadership;Life;Medical Education;Medical Students;Mentors;Modeling;multidisciplinary;National Center for Advancing Translational Sciences;Native Americans;neurological rehabilitation;novel;novel strategies;open data;Oranges;Outpatients;Pacific Island Americans;pandemic disease;Pediatric Hospitals;Persons;Play;Policies;Population;population health;Population Heterogeneity;Positioning Attribute;programs;Public Health;Public Health Informatics;Qualifying;Rare Diseases;recruit;Reduce health disparities;Research;Research Personnel;Research Support;Resource Allocation;Resources;Robotics;Role;school reopening;Schools;Science;Seminal;Services;socioeconomics;structured data;success;synergism;Talents;Technology;Therapeutic;Training;training data;training opportunity;translational applications;Translational Research;Translations;United States Department of Veterans Affairs;United States National Institutes of Health;unstructured data;virtual;virtual laboratory;Vision;Voice;Work

PROJECT_TITLE: Institute for Clinical and Translational Science


ADMINISTERING_IC: AI

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: Project Narrative Targeted covalent inhibitors are an important class of drugs and chemical probes, especially for viral targets, but they are challenging to describe in succinct computational models. This proposal seeks to experimentally determine and computationally model an underdescribed aspect of this compound class, the intrinsic reactivity, which is especially important to predicting the potency of these compounds.

PI_NAMEs: SARAFIANOS, STEFAN G;TORBETT, BRUCE EDWARD (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Academia;Address;Advanced Development;Affinity;antiviral drug development;Binding;Chemicals;Chemistry;combinatorial chemistry;Communities;Compensation;Complex;Computer Models;convolutional neural network;Core Facility;Cysteine;Data Set;Databases;Descriptor;design;Development;Distal;diverse data;Drug Design;Electronics;Evaluation;Fluorides;Funding;Goals;Graph;HIV;HIV Infections;HIV-1;Hydrolysis;improved;Industry;inhibitor;innovation;laboratory experiment;large datasets;Lead;lead optimization;Learning;Libraries;Ligands;machine learning model;machine learning prediction;Measures;Methodology;Methods;Modeling;Modification;Molecular;novel;Pharmaceutical Preparations;Pharmacodynamics;predictive modeling;prevent;Property;prospective;protein structure;Proteins;Proteome;Quantum Mechanics;random forest;rational design;Resources;Running;small molecule;Structure-Activity Relationship;Sulfur;Therapeutic;tool;Toxic effect;training data;trait;United States National Institutes of Health;Viral;virtual;virtual screening;Work

PROJECT_TITLE: Experimental characterization and computational modeling of intrinsic bioreactivity of SuFEx/covalent nucleophile warheads


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PHR: By identifying and overcoming barriers in the translational pathway, increasing scientific collaboration, providing consultative services, clinical research infrastructure, and technology cores that bridge the gap between the laboratory and the clinic, the ICTR helps to speed the pace of scientific discovery, bringing effective therapies to the public, and ultimately improving the health of Americans. Our large ICTR includes the universities and health system in Maryland that have the most research activity. We expect to leverage these organizations to create high impact research that can move Maryland to better health outcomes and health equity.

PI_NAMEs: DAVIS, STEPHEN N.;FORD, DANIEL ERNEST (contact)

PROGRAM_OFFICER_NAME: CURE, PABLO

PROJECT_TERMS: Acceleration;Acute;Address;American;Area;Baltimore;Big Data;burden of illness;career;Chronic;Clinic;clinical care;Clinical Research;Clinical Research Protocols;Clinical Trials;Collaborations;college;Communication;Communities;Community Health;community partners;Complex;Computerized Medical Record;County;Data Sources;disability;Dissemination and Implementation;Ecosystem;effective therapy;Emergency Situation;Environment;Ethnic Origin;Evaluation;Event;expectation;experience;Faculty;Family;Foundations;Goals;Grant;Health;health care delivery;health equity;Health system;hearing disability;Image;improved;Individual;Informatics;informatics infrastructure;Infrastructure;innovation;Institution;Intellectual functioning disability;Interdisciplinary Study;Intervention;investigator training;Joints;Knowledge;Laboratories;Lead;Maryland;Measurable;Measures;Mentors;Methodology;Modeling;multidisciplinary;National Center for Advancing Translational Sciences;older patient;Outcome;Participant;Pathway interactions;patient oriented;physically handicapped;Population;population health;precision medicine;Process;process improvement;Productivity;programs;Race;randomized, clinical trials;recruit;Reduce health disparities;Research;Research Activity;Research Infrastructure;Research Institute;Research Personnel;Research Project Grants;Research Support;Resources;response;responsible research conduct;satisfaction;Science;Secure;Services;skills;Speed;success;System;Technology;translational impact;Translational Research;translational research program;treatment as usual;Trust;underserved rural area;Universities;urban area;Vision;Visual disability;Work

PROJECT_TITLE: Johns Hopkins Institute for Clinical and Translational Research


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: PROJECT NARRATIVE Antibody-drug conjugates (ADCs) are an attractive therapeutic strategy because they can deliver cytotoxic compounds directly to cancer cells, and two ADCs were recently approved for use in metastatic bladder cancer. Radiation is the backbone of a curative, bladder-sparing treatment approach for localized bladder cancer, but the combination of ADCs and RT has not been investigated in any bladder cancer context. We will test the hypothesis that radiation upregulates ADCs targets on bladder cancer cells and leads to a synthetic lethal combination between ADCs and radiation that could be harnessed to improve bladder-sparing treatment outcomes for bladder cancer patients.

PI_NAMEs: MOUW, KENT W (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: aggressive therapy;Antibodies;Antibody-drug conjugates;Biological;biomarker identification;Bladder;Bladder Neoplasm;cancer cell;Cancer cell line;cancer diagnosis;Cancer Model;Cancer Patient;cancer therapy;cell killing;Cessation of life;chemoradiation;chemotherapy;Cisplatin;Clinical;Clinical Research;Clinical Trials;Clinical Trials Design;clinically relevant;common treatment;curative treatments;Cystectomy;cytotoxic;Cytotoxic agent;Data;design;Diagnosis;Disease;Disease Outcome;DNA Damage;DNA Repair Pathway;Gene Mutation;gene repair;Genes;Goals;homologous recombination;homologous recombination deficiency;Human;improved;improved outcome;In Vitro;in vivo;Malignant neoplasm of urinary bladder;Measures;Microtubules;Modeling;Molecular;muscle invasive bladder cancer;Mutation;nectin;Neoadjuvant Therapy;neoplastic cell;novel;novel strategies;Nucleotide Excision Repair;Operative Surgical Procedures;patient derived xenograft model;Patients;Poison;pre-clinical;Pre-Clinical Model;preclinical study;Property;Proteins;Quality of life;Radiation;Radiation Dose Unit;Radical Cystectomy;randomized trial;rational design;recombinational repair;Recurrence;Refractory;Reporting;response;Role;Safety;Survival Rate;System;systemic toxicity;Testing;Therapeutic;Time;Topoisomerase-I Inhibitor;Treatment outcome;trial comparing;tumor;Vertebral column;Work

PROJECT_TITLE: Investigating Interactions Between Radiation and Antibody-Drug Conjugates in Bladder Cancer

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Cellular senescence is a key mechanism driving age-related bone loss and other aging co-morbidities. The overall goal of this application is to leverage our novel tools and mouse models in order to better define the mechanisms driving cellular senescence in the bone microenvironment and to characterize the key senescent cell populations that contribute to skeletal aging.

PI_NAMEs: KHOSLA, SUNDEEP  (contact);MONROE, DAVID G

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Age-Related Bone Loss;age-related disease;Aging;aging mechanism;Apoptosis;Apoptotic;Automobile Driving;BCL1 Oncogene;bone;Bone Marrow;CD 200;CDKN2A gene;cell age;Cell Aging;Cell Cycle;cell growth;Cells;Characteristics;comorbidity;cytokine;Cytometry;Degenerative Disorder;Etiology;Genes;Goals;Growth;Heterogeneity;in vivo;Inflammatory;Intervention;Lead;LOX gene;Lung;Maintenance;Mediating;meetings;Mesenchymal;Modeling;mouse model;Mus;novel;novel strategies;old mice;Osteoblasts;Osteoclasts;Osteocytes;paracrine;Pathway interactions;Phenotype;phenotypic biomarker;Population;Population Heterogeneity;prevent;Proliferating;Protein Analysis;Proteins;Reporter;Resistance;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;single cell proteins;single-cell RNA sequencing;skeletal;Sorting;stem cell biomarkers;Testing;Time;tool;Up-Regulation;Work;Youth

PROJECT_TITLE: Characterization of senescent cell populations in skeletal aging

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project narrative The Hedgehog and Wnt cell-cell signaling pathways govern critical processes in embryonic development, adult stem cell maintenance, regeneration, and in the pathogenesis of several human cancers and birth defects. We propose to use biochemistry, structural, cell and chemical biology, to elucidate essential mechanisms that govern how the Hedgehog and Wnt ligands are released from producing cells, how they are delivered to their receptors, and how the signals are transduced in target cells. These studies will have broad impact on human health, by advancing our understanding of how certain types of cancer and birth defects develop, and by defining novel targets and strategies for cancer therapy.

PI_NAMEs: SALIC, ADRIAN  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: adult stem cell;Area;Binding;Biochemistry;Biological;Biology;cancer therapy;cancer type;Carrier Proteins;Cell Maintenance;Cells;Cellular biology;Cellular Membrane;Chemicals;Cholesterol;Complex;Congenital Abnormality;Dedications;Development;Disease;DNA;Embryonic Development;Environment;Erinaceidae;Event;extracellular;Health;hedgehog signal transduction;Human;intercellular communication;interest;Ligands;Lipids;Malignant Neoplasms;Mediating;Modification;Molecular;Natural regeneration;novel;Oncogenic;Pathogenesis;Pathway interactions;Play;Process;Proteins;receptor;receptor binding;RNA;Role;Signal Pathway;Signal Transduction;Surface;Tissues;tool;Travel;Water;WNT Signaling Pathway;Work

PROJECT_TITLE: Sending and transducing Hedgehog and Wnt signals

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Unlike humans, many animals can regenerate large portions of their body after major injury by using conserved genes and molecular pathways in unique ways. The goal of this proposal is to use the simple and highly regenerative animal Hydra to uncover the regulatory mechanisms that connect injury to the regeneration of new structures. Defining these mechanisms in regenerative animals is a key to ultimately harnessing these powers for therapeutic medicine.

PI_NAMEs: JULIANO, CELINA  (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: adult stem cell;Animals;appendage;Atlases;Behavior;Biology;cell type;Chromosomes;Cnidaria;Development;Event;Fresh Water;Funding;Future;gene conservation;Gene Expression Profile;Gene Expression Regulation;gene regulatory network;Gene Transfer Techniques;Genes;Genome;genome-wide;Genomic approach;Goals;Head;Human;Injury;knock-down;Laboratories;Maps;Medicine;Molecular;Morphogenesis;Natural regeneration;Nerve Regeneration;Nervous System;neurogenesis;Neurons;Organ;Organism;Pathway interactions;regenerative;Regenerative capacity;Regenerative Medicine;Regulatory Element;Research;Resources;response to injury;restoration;Specific qualifier value;Structure;Technology;Therapeutic;transcription factor;transcriptomics;WNT Signaling Pathway;Work

PROJECT_TITLE: Mechanisms of Hydra Development and Regeneration


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Rural Health;Social Determinants of Health

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Narrative The UAMS K12 program is designed to build a diverse cohort of successful translational scientists that can develop and test translational science innovations that will drive real world solutions to enhance health equity for rural and underrepresented populations. The program emphasizes gaining experience and expertise in Translational Science through interdisciplinary training opportunities, mentored research projects, individualized training, and education of mentors. The program will leverage the unique resources available through the TRI to produce a successful and diverse cohort of investigators that will produce Health and Societal Benefits for rural and underserved populations.

PI_NAMEs: FARRAR, JASON ELI;KENNEDY, JOSHUA ;SCHOOTMAN, MARIO  (contact)

PROGRAM_OFFICER_NAME: NAGEL, JOAN DAVIS

PROJECT_TERMS: Arkansas;Assessment tool;career;Child;cohort;Collaborations;college;Communities;Competence;disadvantaged background;Education;Effectiveness;Evaluation;experience;Funding;Geography;Goals;Grant;Health;Healthcare Systems;implementation science;improved;Informatics;innovation;Knowledge;life span;Malignant Neoplasms;Manuscripts;Medical;Medicine;Mentored Clinical Scientist Development Program;Mentors;Mission;Pediatric Hospitals;Population;Process;Productivity;programs;Publishing;recruit;Research Institute;Research Personnel;Research Project Grants;Resources;Rural health equity;Rural Population;Science;skills;success;System;telehealth;Testing;Training;training opportunity;Translational Research;translational scientist;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Universities;Veterans;Woman

PROJECT_TITLE: CTSA K12 Program at the University of Arkansas for Medical Sciences


PHR: PROJECT NARRATIVE  We propose a new T32 Postdoctoral Training Program focused on Health Sciences Innovation and Entrepreneurship (HSIE) Training Program, which will offer mentored research training to postdoctoral fellows in the Colleges of Medicine, Nursing, Pharmacy and Public Health. This inter-professional training will be coupled to didactic and experiential learning to equip trainees with the skillset to catalyze research discoveries into health care applications. Program graduates will be uniquely positioned as translational scientists to succeed as academic investigators or pursue other exciting career options that depend on scientific and operation principles of the translation process.

PI_NAMEs: IMIG, JOHN D (contact)

PROJECT_TITLE: CTSA Postdoctoral T32 at University of Arkansas for Medical Sciences


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Congenital Heart Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Patient Safety;Pediatric;Rare Diseases;Rural Health;Social Determinants of Health

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative This collaborative research project is between two large academic health centers with long-standing clinical partnership in the area of pediatric and adult congenital heart disease and acquired pediatric heart disease. The proposed Clinical Research Center will develop and participate in research protocols as part of the Pediatric Heart Network. The goal is to generate new understanding of health and disease in this population with resulting equitable improvement in outcomes.

PI_NAMEs: BEZOLD, LOUIS ;CNOTA, JAMES  (contact)

PROJECT_TERMS: Acceleration;Address;Adult;adverse outcome;Affect;Anesthesia procedures;Appalachian Region;Area;Blood Vessels;Cardiac Surgery procedures;Cardiology;Cardiovascular system;career;career development;Caring;Case Management;Child;Child Mental Health;Childhood;Clinic;Clinical;clinical center;Clinical Research;clinical research site;Clinical Trials Network;Collaborations;Communities;community engagement;congenital heart abnormality;Congenital Heart Surgery;Data Coordinating Center;data integration;Data Science;Data Set;Databases;Dimensions;Disease;Disparity;diversity and inclusion;Economics;Electronic Health Record;Enrollment;Ensure;Equity;experience;Faculty;Family;Fostering;Future;Generations;Genomics;Geography;Goals;Health;health disparity;health outcome disparity;Heart;Heart Diseases;Hospitalization;Image;improved;improved outcome;Indiana;industry partner;Inequity;Infrastructure;innovation;Inpatients;Institution;Institutional Review Boards;Joints;Kentucky;Laboratories;Learning;Location;Magnetic Resonance Imaging;medical specialties;member;Mentors;Modeling;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;novel therapeutics;Ohio;Outcome;Outpatients;Outreach Research;Participant;patient population;Patients;Pediatric Cardiac Genomics Consortium;Pediatric Hospitals;physical conditioning;Population;Positioning Attribute;Productivity;programs;Protocols documentation;Quality of life;readmission rates;Recommendation;recruit;Registries;Reporting;Research;Research Personnel;Research Project Grants;Resources;Role;Rural;Safety;Site;social;Societies;Socioeconomic Factors;Special Population;Structure;symposium;Testing;Thoracic Surgeon;Time;Training;Translational Research;Underrepresented Populations;United States;Universities;West Virginia

PROJECT_TITLE: Pediatric Heart Network Joint Heart Program Consortium


NIH_SPENDING_CATS: Neurosciences

PHR: Title: Defining microtubule cytoskeleton regulatory pathways in development and disease P.I. Kassandra Ori-McKenney Project Narrative: DYRK1a kinase has been implicated in a range of intellectual disability disorders and neurodegenerative diseases. Little is known about the molecular network of this kinase and the distinct roles it plays during different cellular functions, but we have found that DYRK1a regulates the microtubule cytoskeleton by directly phosphorylating several microtubule-associated proteins (MAPs). This proposal seeks to delineate the pathways that orchestrate the dynamic microtubule cytoskeleton by combining live imaging of cellular and organismal systems with in vitro biochemical reconstitution assays. The overall goal of this project is to elucidate the multifaceted mechanisms of the DYRK1a-MAP network in regulating essential microtubule-based processes in order to provide insight into the contribution of this pathway to multiple human diseases.

PI_NAMEs: ORI-MCKENNEY, KASSANDRA MARIE (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Affect;Architecture;Behavior;Binding;Binding Proteins;Biochemical;Biological Assay;Cell Culture Techniques;Cell Line;Cell Physiology;Cells;Complement;Cytoskeletal Modeling;Cytoskeleton;Data;Development;Disease;Drosophila genus;Environment;Enzymes;Epithelial Cells;ex vivo imaging;Exhibits;experimental study;Genetic;Goals;human disease;Human Pathology;Imaging Techniques;In Vitro;in vivo;Individual;insight;Intellectual functioning disability;interdisciplinary approach;live cell imaging;Malignant Neoplasms;Microtubule-Associated Proteins;Microtubules;Molecular;Morphogenesis;Motor;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurons;neuropathology;Output;Pathologic;Pathway interactions;Pattern;Peripheral Nervous System;Phosphorylation;Phosphotransferases;Play;Post-Translational Protein Processing;Process;Proteins;Publishing;reconstitution;Regulation;Regulatory Pathway;Role;Structure;System;Total Internal Reflection Fluorescent;Tubulin


NIH_SPENDING_CATS: Genetics

ORG_CITY: Boulder

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE Regulated exocytosis is central to a wide range of fundamental physiological processes. Mechanistic insights gleaned from this study will substantially broaden our knowledge of regulated exocytosis and will shed light upon the pathogenesis of diseases linked to regulated exocytosis.

PI_NAMEs: SHEN, JINGSHI  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Biochemical;Biological Process;Candidate Disease Gene;Cell Physiology;Cells;Clathrin;Clustered Regularly Interspaced Short Palindromic Repeats;Coupled;CRISPR screen;Cytosol;Dedications;Development;Disease;Endocytosis;enhancer-binding protein AP-2;Exocytosis;Genetic Screening;Genetic study;Glean;GLUT 4 protein;Goals;Homeostasis;human disease;insight;Insulin;Knowledge;Lead;Light;Link;Mediating;Membrane;Modeling;Molecular;Molecular Chaperones;novel therapeutic intervention;Nutrient;Pathogenesis;Pathway interactions;Physiological;Physiological Processes;Proteins;Research;response;Signal Transduction;Stimulus;trafficking;Vesicle;Viral;Work

PROJECT_TITLE: Discovering protein networks underlying regulated exocytosis


NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Cerebrovascular;Emerging Infectious Diseases;Heart Disease;Heart Disease - Coronary Heart Disease;Infectious Diseases;Stroke

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative: This grant application will investigate the poorly understood membrane lipid flip-flop dynamics at molecular and cellular levels, aiming to elucidate its mechanisms in health and disease, and to facilitate the development of novel therapies for conditions like stroke, heart attack, cancer, pregnancy complications, neurological disorders, and infectious disease including AIDS and CoVID19.

PI_NAMEs: YANG, HUANGHE  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Applications Grants;Atherosclerosis;Calcium;Cell fusion;Cell membrane;Cells;Cessation of life;Communicable Diseases;COVID-19;Development;Disease;Epilepsy;Family member;Health;Human;Infection;innovation;Integral Membrane Protein;Ion Channel;Ion Transport;Ions;Life;lipid transport;Lipids;Malignant Neoplasms;Mediating;Membrane;Membrane Lipids;Methods;Molecular;Monitor;Movement;Muscular Dystrophies;Myocardial Infarction;Nervous System Disorder;novel;novel therapeutics;Phospholipids;Physiological;Pregnancy Complications;prevent;Process;Protein Family;Role;Signal Transduction;Stroke;stroke-like outcome;voltage;Work

PROJECT_TITLE: Advancing mechanistic understanding of membrane ion and lipid transport


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE The efficient subcellular localization of specific RNAs is a widespread process that is important for the proper functioning of diverse cell types across a wide range of organisms. Despite this, our understanding of the molecular language that underlies the regulation of this process is quite sparse. This proposal uses genome engineering, subcellular fractionation, single molecule imaging, and high-throughput sequencing to dissect the rules that govern how RNAs are distributed within cells with a focus on discovering RNA cis-elements and RNA-binding trans-factors that regulate the process.

PI_NAMEs: TALIAFERRO, JEFFERSON MATTHEW (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Binding Proteins;Cell Fractionation;cell type;Cells;combinatorial;Consumption;Defect;Destinations;Development;Drosophila genus;Elements;Environment;Eukaryotic Cell;experimental study;Foundations;Gene Expression;Genome engineering;Goals;High-Throughput Nucleotide Sequencing;Human;Knowledge;Language;Language Development;Lead;Location;Mediating;Modeling;Molecular;molecular imaging;Nervous System Disorder;new technology;Organism;Outcome;parallelization;Phenotype;Post-Transcriptional Regulation;predictive modeling;Process;Regulation;RNA;RNA Binding;RNA Splicing;RNA-Binding Proteins;single molecule;Site;System;Time;trafficking;Transcript;transcriptome;Work

PROJECT_TITLE: Understanding the regulatory language of RNA localization

STUDY_SECTION: MRAF

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - F Study Section[MRAF]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Alcoholism, Alcohol Use and Health;Clinical Research;Lung;Microbiome;Neurosciences;Orphan Drug;Physical Injury - Accidents and Adverse Effects;Rare Diseases;Substance Misuse

ORG_DEPT: SURGERY

PHR: Project Narrative Damaging more than just the skin, burn injury can lead to infection and multi-organ failure, often involving damage to the intestine and shifts in the gut microbiome dysbiosis, which allows translocation of bacteria and bacterial products into the circulation and triggers excessive inflammation in the lung and the brain. Nearly half of all adult burn patients consumed alcohol prior to sustaining their injuries and, and since alcohol intoxication and burn injury independently effect the gut microbiome, subjects with the combined insult of alcohol and injury have heightened inflammatory responses and worse outcomes. This MIRA renewal grant will allow us to 1) further examine alterations in the intestine after burn injury an determine if these changes contribute to aberrant inflammatory responses in the lung and the brain and 2) identify interventions to accelerate restoration of intestinal homeostasis using our clinically-relevant model of alcohol intoxication and burn injury and in burn patients who are at risk of developing failure of critical organs like the lung and the cognitive dysfunction.

PI_NAMEs: KOVACS, ELIZABETH J. (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Acceleration;Acute Respiratory Distress Syndrome;Address;Adult;Alcohol consumption;alcohol effect;alcohol exposure;alcohol misuse;Alcoholic Intoxication;Alcohols;Alveolar Macrophages;Bacteria;Blood - brain barrier anatomy;Brain;Burn injury;Burn Trauma;Cells;Circulation;Clinical;clinically relevant;Cutaneous;Delirium;design;Development;drinking;dysbiosis;Environmental Risk Factor;Failure;fecal microbiome;Grant;gut microbiome;Impaired cognition;improved;improved outcome;Incidence;Infection;Inflammation;Inflammatory Response;Inhalation;Injury;Intervention;intestinal epithelium;intestinal homeostasis;Intestines;Intoxication;Knowledge;Lung;Lung infections;lung injury;Macrophage;microbiome;Microglia;Modeling;Morbidity - disease rate;mortality;mouse model;Multiple Organ Failure;Natural Immunity;neuroinflammation;novel therapeutics;Organ;Outcome;patient population;Patient-Focused Outcomes;Patients;Persons;Pneumonia;Population;Predisposition;Process;programs;Pulmonary Inflammation;Research;response;restoration;Risk;Sampling;Secondary to;Skin;systemic inflammatory response;Time;Trauma;United States

PROJECT_TITLE: Alcohol and Burn Trauma: Multi-organ Inflammatory Responses


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Congenital Heart Disease;Congenital Structural Anomalies;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Pediatric;Rare Diseases;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The GATeway to tHe wEst consoRtium (GATHER) is a collaboration between Washington University School of Medicine/St. Louis Children’s Hospital and the University of Colorado/Children's Hospital Colorado aimed at continuing progress in pediatric heart disease care and outcomes as a Pediatric Heart Network (PHN) Clinical Research Center. The consortium brings together unique expertise and resources to complement those of the PHN and draws from a geographically diverse population in the Midwest and Mountain regions of the U.S. with a strong commitment to enhancing diverse perspectives in study populations and training junior investigators. The GATHER consortium aims to develop a multi-center prospective registry, PROSPECT-HF, to study practice variation and response to guideline-directed medical therapy in pediatric and single ventricle heart failure (HF) and to embed clinical trials of novel HF therapies. As the prevalence of HF in children grows without a significant improvement in outcomes, this proposal offers a paradigm shift in the way that HF therapies are studied and administered in children and may offer insight into how to individualize HF therapies in this population.

PI_NAMEs: BUCHOLZ, EMILY MARIE;GLATZ, ANDREW CHARLES (contact);MIYAMOTO, SHELLEY DEANNE;SILVA, JENNIFER N

PROJECT_TERMS: Adult;advanced analytics;Advocate;Area;Basic Science;Big Data;biobank;Cardiac Myosins;Cardiology;Caring;Child;Childhood;Circulation;Clinical;Clinical Research;Clinical Trials;Collaborations;Colorado;Common Ventricle;Communities;community engagement;community partners;Complement;congenital heart abnormality;Creativeness;Data;Data Collection;data sharing;design;Development;digital health;disease model;equity, diversity, and inclusion;Ethnic Origin;Etiology;Family;family support;Foundations;Functional disorder;Funding;Geography;Goals;Guidelines;Health;health care service utilization;health disparity;Health Services Research;Health Technology;Heart;Heart Diseases;Heart failure;heart failure with reduced ejection fraction;improved;Individual;Informatics;innovation;insight;Institution;Investments;Leadership;Machine Learning;Medical;medical schools;Mentorship;Midwestern United States;Mission;Modeling;multiple omics;National Heart, Lung, and Blood Institute;novel;novel strategies;Operative Surgical Procedures;Outcome;Outcome Measure;Outcomes Research;palliative;Participant;Patient Outcomes Assessments;patient population;patient response;Patient-Focused Outcomes;Patients;pediatric heart failure;Pediatric Hospitals;Phase Ib/II Clinical Trial;Population;Population Heterogeneity;Pragmatic clinical trial;Prevalence;prospective;Race;Recording of previous events;recruit;Registries;Research;Research Design;Research Personnel;Research Support;Resources;responders and non-responders;response;risk prediction model;Role;Single ventricle congenital heart disease;Site;skills;social health determinants;socioeconomics;Solid;study population;Techniques;Technology;tool;Training;Translational Research;Treatment Failure;treatment response;Universities;Variant;Washington;wearable device;Work

PROJECT_TITLE: Pediatric Heart Network - GATHER - between Washington University in St Louis and Children's Hospital Colorado


NIH_SPENDING_CATS: Data Science;Genetics;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Narrative Drugs can cure disease and reduce suﬀering. Unfortunately, for some patients drugs cause unacceptable side eﬀects or do not work at all. Our research focuses on discovering the reasons for variation in individual drug response. We use computational methods to combine molecular, cellular and clinical data to gain a deeper understanding of how drugs work in order to enable more precise prescribing decisions.

PI_NAMEs: ALTMAN, RUSS BIAGIO (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Adverse event;Automobile Driving;Basic Science;biobank;Clinical;Clinical Data;Collaborations;Computerized Medical Record;Computing Methodologies;Critical Pathways;Data;data integration;Data Set;Databases;Disease;Drug Interactions;Drug Modulation;Drug Targeting;Environment;Environmental Exposure;Epigenetic Process;epigenetic variation;Explosion;Gene Expression;Genes;Genetic;Genetic Variation;Goals;Human Genetics;Individual;Knowledge;knowledgebase;Lead;Medical;Methods;Modeling;Molecular;Molecular Target;novel;Pathway interactions;Patients;Performance;Pharmaceutical Preparations;Pharmacogenetics;Pharmacotherapy;Phenotype;Physiology;Population;Proteins;Proteome;Research;response;screening;side effect;Source;three dimensional structure;Variant;Work

PROJECT_TITLE: Computational methods for characterizing sources of variability in drug response

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-H (56)]


NIH_SPENDING_CATS: Aging;Biotechnology;Genetics;Human Genome;Neurodegenerative;Orphan Drug;Rare Diseases

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Molecular machines that function in DNA repair maintain integrity of the genome by promoting faithful repair of the most genotoxic DNA lesions and faithful genome replication. Defects in their regulation can lead to genetic instability and chromosomal rearrangements causing cancer, aging, and diseases associated with progressive expansion of repeated sequences (including Huntington's disease, myotonic dystrophy and Fragile X syndrome). Understanding the fundamental molecular mechanisms of how DNA repair is regulated and its dysregulation will reveal features, which can be exploited in developing novel therapeutics.

PI_NAMEs: SPIES, MARIA  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Affect;age related neurodegeneration;Aging;Binding;Binding Proteins;Biochemistry;Biology;Biophysics;BRCA2 gene;cancer cell;Cancer Etiology;Cells;Chemicals;Chemotherapy and/or radiation;Chromosomal Rearrangement;Complex;cytotoxic;Defect;Disease;DNA biosynthesis;DNA Damage;DNA lesion;DNA metabolism;DNA Repair;DNA Repair Gene;DNA Repeat Expansion;DNA Replication Damage;DNA replication fork;DNA Structure;DNA-Directed DNA Polymerase;Equilibrium;Event;Expanded DNA Repeat;Fragile X Syndrome;Genetic;Genetic Recombination;Genome;genome integrity;Genome Stability;genotoxicity;Goals;helicase;homologous recombination;Human;human DNA;Huntington Disease;Individual;Kinetics;macromolecular assembly;Maintenance;Malignant Neoplasms;Mediator;Microscopic;Molecular;molecular dynamics;Molecular Machines;Myotonic Dystrophy;Neurodegenerative Disorders;novel therapeutics;Nucleoproteins;Post-Translational Protein Processing;programs;Proteins;Rad51 recombinase;RAD52 gene;Regulation;repaired;replication factor A;Research;Resistance development;Signal Transduction;single molecule;Single-Stranded DNA;Sorting;Surface;therapeutic target;tool;Visualization;Yeasts

PROJECT_TITLE: Assembly and Dynamics of Molecular Machines in Genome Maintenance

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Congenital Heart Disease;Congenital Structural Anomalies;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Pediatric;Precision Medicine;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE The Pediatric Heart Network New York Consortium (PHN-NYC) draws upon our unique, interdisciplinary expertise to: 1) create a novel infrastructure, linking existing locally held clinical registry, administrative, social determinants of health and National Death Index data with prospectively collected genomic, proteomic, and clinical trial data to support enhanced registry-based investigations, capable of identifying modifiable mediators of health inequities; 2) expand engagement of families affected by congenital heart disease traditionally underrepresented in research; and 3) leverages existing NIH-funded investigator training initiatives to expand and support a next generation of diverse congenital heart clinical researchers.

PI_NAMEs: ANDERSON, BRETT ROMEO;GELB, BRUCE D;LEWIS, MATTHEW ;RICHMOND, MARC ERIC (contact)

PROJECT_TERMS: Adult;Affect;beneficiary;Big Data;biobank;Birth;Black race;Cardiac Surgery procedures;career;Caribbean Hispanic;Caring;Cessation of life;Child;Childhood;Clinical;clinical outcome measures;Clinical Research;clinical risk;Clinical Trials;Clinical Trials Design;Communities;community engagement;Congenital Abnormality;congenital heart abnormality;Congenital Heart Defects;Congenital Heart Surgery;contextual factors;Data;data lake;Data Linkages;Data Sources;Databases;Development;Diagnostic;Disease;disorder subtype;Disparity;Economics;Education;Effectiveness;Emergency department visit;Environment;Family;Funding;Future;Genetic;Genomics;hazard;health inequalities;Heart;Heart Research;Heterogeneity;high risk;Hispanic;Hospital Mortality;Hospitalization;Hospitals;improved;improved outcome;Income;indexing;Individual;Inequity;Infrastructure;innovation;Inpatients;Intervention;Investigation;investigator training;Length of Stay;life span;Link;Low income;lower income families;Mediator;Medicaid;Mentors;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Neighborhoods;New York;next generation;Not Hispanic or Latino;novel;operation;Operative Surgical Procedures;Outcome;patient oriented;patient population;patient subsets;Patients;Perioperative;Phenotype;Population;post-transplant;Postoperative Period;Pragmatic clinical trial;prospective;Proteomics;Provider;Race;Registries;repaired;Reporting;Research;Research Personnel;Resources;Risk Adjustment;Risk Factors;Science;social determinants;social health determinants;socioeconomics;Source;Spanish;Tissues;Training;Transplantation;Underrepresented Populations;United States;United States National Institutes of Health


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE This proposed study will investigate the function of lysosomal membrane transporting proteins and lysosomal protein quality control system. Lysosome dysfunction leads to lysosomal storage diseases (LSD, ~70 in humans) and contributes to aging-related neurodegenerative diseases. Our discoveries will shed light on the development of new treatment strategies for LSDs and neurodegenerative diseases.

PI_NAMEs: LI, MING  (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: age related neurodegeneration;Alzheimer's Disease;Cell Proliferation;Dependence;detection of nutrient;Development;Functional disorder;Future;Human;Huntington Disease;Ion Channel;Link;lysosomal proteins;Lysosomal Storage Diseases;lysosome membrane;Lysosomes;Membrane Proteins;Membrane Transport Proteins;metabolomics;Methods;Neurodegenerative Disorders;novel therapeutic intervention;Organelles;Parkinson Disease;Pathway interactions;Process;protein degradation;Proteins;Quality Control;reconstitution;Recycling;Regulation;System;Ubiquitin;ubiquitin-protein ligase

PROJECT_TITLE: Functional characterization of lysosome membrane and its protein quality control system


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_DEPT: BIOLOGY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: PROJECT NARRATIVE Mutation and recombination are the sources of all genetic variation, the fuel of evolution, and the ultimate cause of heritable diseases as well as of many cancers. This proposal describes a set of research projects aimed at understanding how and why these fundamental genetic processes differ among humans and across species.

PI_NAMEs: PRZEWORSKI, MOLLY F (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Cancer Biology;Disease;Evolution;Genetic;Genetic Processes;Genetic Recombination;Genetic study;Genetic Variation;Genome;Genomic approach;Germ Lines;Goals;Heritability;Human;Human Genetics;Individual;interest;Learning;Malignant Neoplasms;mathematical model;Meiosis;Meiotic Recombination;Mutagenesis;Mutation;Organism;Point Mutation;Population Genetics;Process;Property;Research Project Grants;sex;Source;Statistical Data Interpretation;Time;tool;Variant;Vertebrates;Work

PROJECT_TITLE: Mechanisms of mutation and recombination and their evolution in vertebrates


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: JAMAICA

ORG_NAME: YORK COLLEGE

PHR: Project Narrative The purpose of this study is to test the protection of mitochondria and retinal ganglion cells in adult mice with high-density aromatic peptides (HDAP) following optic nerve crush. This approach has novel potential to optimize mitochondria functions and to minimize oxidative stress that occurs following neural trauma.

PI_NAMEs: MACNEIL, MARGARET  (contact)

PROGRAM_OFFICER_NAME: BISSONETTE, GREG

PROJECT_TERMS: Adult;Affect;Animals;Axon;Blood-Retinal Barrier;Calcium;Cardiolipins;Cell Survival;Cells;Cellular Membrane;Cessation of life;Crista ampullaris;Cytoprotection;Dendrites;density;Diabetic Retinopathy;experience;Exposure to;Eye;Functional disorder;ganglion cell;Ganglion Cell Layer;Glaucoma;Glutamates;improved;in vivo;Injury;Inner mitochondrial membrane;Laboratories;Length;Maintenance;Membrane Potentials;Metabolic;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Morphology;Mus;Nerve Crush;Nerve Degeneration;neural;Neurodegenerative Disorders;Neurons;neuroprotection;novel;Optic Nerve;Optic Nerve Injuries;Oxidative Stress;Oxidative Stress Induction;Peptides;preservation;prevent;Procedures;Production;red dye CMXRos;Retina;Retinal Ganglion Cells;Serum;Starvation;Surface;Synapses;Testing;Transgenic Mice;Trauma;Width

PROJECT_TITLE: Neuroprotection of retinal ganglion cells.

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-W (SU)]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Suicide;Suicide Prevention;Violence Research;Youth Violence;Youth Violence Prevention

PHR: PROJECT NARRATIVE Disproportionately high rates of early substance use among American Indian (AI) youth put them at greater risk for developmental disruption and long-term health consequences than their non-AI peers. Social network researchers have examined adolescents’ social networks and used them to enhance prevention; these efforts, however, have not reached AI communities. This longitudinal mixed methods study will collect social network data at the individual and community level to explore the structure and function of AI adolescent social networks and examine how network features relate to risk and protection for substance use, suicide, and exposure to violence over time.

PI_NAMEs: IVANICH, JERREED DEAN (contact);SCHULTZ, KATIE

PROGRAM_OFFICER_NAME: VIDAL, SARAH

PROJECT_TERMS: Adolescence;Adolescent;Adolescent Risk Behavior;Alaska Native;American Indian community;American Indians;Area;Behavior;career;Characteristics;Childhood;cohort;Communities;community engaged research;Community Networks;community organizations;community-level factor;Complex;Coordination and Collaboration;critical period;Data;design;Development;disorder prevention;Disparity;early onset substance use;Effectiveness;effectiveness testing;Environmental Risk Factor;Exclusion;experience;Family;Gender;Geography;Health;Health Promotion;Indian reservation;Individual;innovation;Institution;Interpersonal Relations;Intervention;Interview;Kinship Networks;Leadership;lens;Location;Maintenance;Measures;Methods;Mission;multidisciplinary;National Institute of Drug Abuse;Nature;Northern Plains;Outcome;Pathway Analysis;peer;Policies;Population;Prevention;Prevention approach;Prevention strategy;preventive intervention;Principal Investigator;programs;protective factors;Race;Research;Research Personnel;reservation-based;Reservations;resilience;Resources;Risk;Risk Factors;Role;Schools;Services;Shapes;social;Social Development;social influence;Social Interaction;Social Network;social network intervention;Structure;substance misuse;substance use;substance use prevention;suicidal risk;Suicide;Surveys;Testing;theories;Time;tribal community;Tribes;Violence;violence exposure;virtual;Work;Youth

PROJECT_TITLE: Tribal Adolescent Connections Study - R01

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-P (55)]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative My proposed research program will provide technologies to extend the reach of optical microscopy, from subcellular dynamics up to entire model organisms. At the same time, we will bridge these different scales through smart microscopy, which autonomously adjusts temporal and spatial resolution to efficiently (in terms of time, amount of data and sample irradiation) explore a specimen. If successful, these technologies may prove transformative in biological and biomedical research.

PI_NAMEs: FIOLKA, RETO PAUL (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TITLE: Transformative microscopes to image across spatiotemporal scales


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE All animal cells use microtubules during division to create the mitotic spindle and during differentiation for cell polarity, shape, and transport. The proposed research will define the mechanisms that control how microtubules become spatially organized to carry out these fundamentally different processes. An understanding of the mechanisms that control microtubule organization should provide therapeutic insight into the growing number of specific birth defects and human cancers that have been linked to defects in the microtubule cytoskeleton.

PI_NAMEs: FELDMAN, JESSICA LYNN (contact)

PROJECT_TERMS: Address;Afferent Neurons;Animals;Apical;apical membrane;Axon;Caenorhabditis elegans;Carcinoma;cell behavior;Cell Differentiation process;Cell Physiology;Cell Polarity;cell type;Cells;Cellular biology;Centrosome;Cilia;Congenital Abnormality;Cytoskeleton;Defect;Dendrites;Development;Developmental Biology;Epithelial Cells;Generations;Genetic;Goals;Hand;Human;in vivo Model;insight;intestinal epithelium;Label;Link;Location;Malignant Neoplasms;Maps;Microcephaly;Microtubule-Organizing Center;Microtubules;Mitosis;Mitotic spindle;Molecular;Muscle Fibers;National Institute of General Medical Sciences;Neurons;novel;Nuclear Envelope;Organelles;Physiological;Process;Property;Proteins;Research;Shapes;Site;Surface;Testing;Therapeutic;Tissues;tool

PROJECT_TITLE: Mechanisms controlling microtubule organization during cell differentiation


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE The overall vision of Stanford’s CTSA-supported research “Hub” is to transform clinical, translational, and science of translation research and education (CTSRE), by making CTSRE more effective and efficient at discovery, clinical, translational, and science of translation research and education to serve the health needs of diverse individuals. In the next seven years, we believe the Stanford CTSA can best achieve this vision by capitalizing on our greatest strengths, namely a) educating and training the next generation of clinical, translational, and science of translation researchers; b) developing and implementing across all elements of our CTSA the principles of the science of translation, including rigor and reproducibility (SPORR), team science, health policy, and Research Equity, Accessibility, Diversity, and Inclusiveness (READI); and c) developing and implementing innovative, data driven, and clinical operational approaches to accelerate, scale, and diversify our translational research and science of translation efforts. We aim to employ state-of-the-field evaluative approaches to determine the effectiveness and maximize the impact of our Stanford CTSA CTSRE efforts locally, regionally, nationally, and across our networks, including the CTSA consortium.

PI_NAMEs: DESAI, MANISHA ;FELSHER, DEAN W;O'HARA, RUTH M (contact)

PROGRAM_OFFICER_NAME: ATIENZA, AUDIE A

PROJECT_TERMS: Acceleration;Child;Clinical;clinical center;Clinical Research;clinical trial participant;Collaborations;Communities;community engagement;community partners;Data;Data Science;data science infrastructure;design;diversity and inclusion;Education;education resources;effectiveness evaluation;Elderly;Elements;Ensure;Environment;Equitable healthcare;Equity;Ethics;Goals;Hawaii;Health;health care delivery;Health Policy;Health Services Accessibility;Healthcare Systems;implementation science;improved;Individual;informatics infrastructure;Information Systems;Infrastructure;innovation;Institution;Knowledge;Leadership;life span;Measures;Methods;Minority;Mission;National Center for Advancing Translational Sciences;next generation;Outcome;Patients;Persons;Population;Population Heterogeneity;Positioning Attribute;Process;Productivity;programs;Public Health Informatics;Rare Diseases;Reproducibility;Research;Research Personnel;Research Support;Research Training;Resources;Science;Services;skills;Time;tool;Training;Training and Education;training opportunity;Translating;translational medicine;translational pipeline;Translational Research;translational scientist;Translations;Universities;Vision;Woman

PROJECT_TITLE: Stanford Center for Clinical and Translational Research and Education


PHR: Project Narrative Genetic exchange between species, or hybridization, has made major contributions to the genomes of species across the tree of life, including our own. We propose to characterize the consequences of hybridization from the single gene to the genome-wide scale. We will build maps of genetic incompatibilities caused by hybridization, investigate the molecular mechanisms through which incompatibilities act, and discover variables impacting the outcomes of hybridization at a genome-wide scale.

PI_NAMEs: SCHUMER, MOLLY  (contact)

PROJECT_TERMS: Address;Base Pairing;Biological Models;Biological Process;Chromosome Mapping;Computing Methodologies;density;Disease;DNA Transposable Elements;Embryo;Evolution;Family;Funding;Genes;Genetic;Genetic Recombination;Genome;genome sequencing;genome-wide;Genomic Hybridizations;Genomics;Human;Hybrids;Life;Maps;Melanoma;Modernization;Molecular;Outcome;Population;Process;protein complex;Recording of previous events;Research;Research Personnel;Role;Shapes;Trees;Vertebrates;Work

PROJECT_TITLE: The population genomics of hybridization: from genetic incompatibilities to genome evolution


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Social Determinants of Health

PHR: The overall objective of the proposed work is to test how individuals respond to repeated bouts of social success or defeat and the neurological and physiological mechanisms underpinning these long-term changes. By coupling together a novel mechanistic framework, Bayesian updating, with high-resolution behavioral tracking and molecular techniques in a powerful naturally clonal vertebrate model system, this work will provide comprehensive insight into the patterns and mechanisms of social status gain and loss. This work has implications for understanding how the effects of positive and negative social experiences can ripple forward through the lifetime of an individual.

PI_NAMEs: LASKOWSKI, KATE  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TITLE: Bayesian updating as a framework to predict the cognitive, neural and physiological mechanisms underlying social status


NIH_SPENDING_CATS: Genetics;Neurodegenerative

PHR: Project Narrative (from parent grant): Mammalian cells use biological zip codes to transport mRNAs, which encode the information for the synthesis of proteins, to specific locations in the cell, so that proteins are made in their appropriate location. This RNA localization process is critical to early development, learning and memory, and at the level of the individual cell, to the secretion of hormones and neurotransmitters as well the cell surface localization of proteins functioning in signaling and cell-cell communication. The findings from this study are expected to reveal new mechanisms of RNA localization and identify conserved pathways that may be dysregulated in diseases of development, metabolism, and ageing.

PI_NAMEs: NICCHITTA, CHRISTOPHER V. (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Acceleration;Address;Aging;Biogenesis;Biological;Biology;Cell Communication;Cell surface;Cells;cohort;Coupled;Cytoplasmic Granules;Development;Disease;Dissection;Endoplasmic Reticulum;Experimental Models;frontotemporal lobar dementia amyotrophic lateral sclerosis;Gene Expression;Genes;Genetic Transcription;Health;Hormone secretion;Individual;insight;Knowledge;Learning;Length;Light;Link;Location;Macromolecular Complexes;Mammalian Cell;Membrane;Memory;Messenger RNA;Metabolism;Molecular;mRNA Export;Neurodegenerative Disorders;Neurotransmitters;Organelles;parent grant;Pathway interactions;Phase;Population;Post-Transcriptional Regulation;posttranscriptional;Process;Protein Biosynthesis;protein function;Proteins;recruit;Research;response;RNA;RNA-Binding Proteins;Role;Sampling;Signal Transduction;Stress;stress granule;transcriptome;Translation Initiation;Untranslated Regions

PROJECT_TITLE: Research Supplements to Promote Diversity in Health-Related Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homelessness;Lung;Lung Cancer;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Homeless people have a 3.5-fold higher prevalence of cigarette smoking in comparison to non-homeless people, contributing to 2-fold higher rates of lung cancer and 3- to 5-fold higher rates of tobacco-attributable death. To advance the public health objective of improving smoking cessation in socioeconomically disadvantaged populations, we will conduct a community-based randomized controlled trial to assess the effect of financial incentives on smoking abstinence among adult smokers at Boston Health Care for the Homeless Program. The findings of this study could inform tobacco treatment efforts for the 934,000 people served annually in US Health Care for the Homeless programs.

PI_NAMEs: BAGGETT, TRAVIS P. (contact)

PROGRAM_OFFICER_NAME: PRUTZMAN, YVONNE M

PROJECT_TERMS: Abstinence;Address;Adult;Aftercare;Alkaloids;Anabasine;Area;arm;attributable mortality;Behavior Therapy;Behavioral;behavioral economics;Behavioral Sciences;Boston;Carbon Monoxide;Cessation of life;cigarette smoke;cigarette smoking;Clinic;Clinical Trials;Cognitive;Collaborations;Communities;comorbidity;comparison control;contextual factors;Control Groups;Counseling;Data Collection;design;Dimensions;disparities in morbidity;Distant;Economically Deprived Population;Enrollment;Exhalation;experience;experimental study;financial incentive;Future;Goals;Guidelines;Healthcare;High Prevalence;Homeless persons;Homelessness;improved;Incentives;Incidence;Income;innovation;Intervention;Interview;Investigation;Malignant neoplasm of lung;malignant oropharynx neoplasm;Medical center;Methods;Modification;mortality;multidisciplinary;nicotine patch;nicotine replacement;Operant Conditioning;Participant;Patients;payment;Persons;Pharmacological Treatment;Population;Productivity;programs;Public Health;Publishing;Randomized;Randomized, Controlled Trials;recruit;reduce tobacco use;Resistance;Resources;response;retention rate;Rewards;Sampling;Schedule;Shelter facility;Site;Smoke;Smoker;Smoking;smoking abstinence;smoking cessation;socioeconomic disadvantage;standard care;Testing;theories;Time;Tobacco;Tobacco use;treatment effect;treatment response;Urine;Vulnerable Populations;Work

PROJECT_TITLE: Financial incentives for homeless smokers: A community-based RCT

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Digestive Diseases;Foodborne Illness;Infectious Diseases

ORG_CITY: SALT LAKE CITY

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Infectious diarrhea is a growing public health issue in the United States and globally a major cause of death in children under 5. We have identified an evolutionary conflict between mammals and bacteria that cause diarrhea by targeting the host receptor guanylyl-cyclase c, which maintains fluid balance in the gut. The goal of this project is to expand our study of this conflict and identify inhibitors of the bacterial toxins to guide potential treatment of infectious diarrhea.

PI_NAMEs: CULBERTSON, MICHELLE  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Address;Affinity;Antibiotics;arms race;Bacteria;Bacterial Infections;Bacterial Toxins;Basic Science;Binding;Biochemical;Biological Assay;candidate identification;Cause of Death;Cells;Cessation of life;Child;Childhood;Chiroptera;Clinical;clinical care;Clinical Skills;Clinical Treatment;Codon Nucleotides;Communicable Diseases;Communication;Conflict (Psychology);Cyclic GMP;Dehydration;design;Diarrhea;diarrheal disease;Educational process of instructing;Electrolyte Balance;enteric infection;enterotoxigenic Escherichia coli;enterotoxin receptor;Enterotoxins;Evolution;Exposure to;fitness;Fluid Balance;fundamental research;Future;Genes;genetic analysis;Genetic Variation;global health;Goals;Grant;Human;improved;In Vitro;Infection;inhibitor;Intestines;Knowledge;Learning;Ligands;Liquid substance;Malnutrition;Mammals;Measures;medical schools;Medicine;member;Mentors;Mentorship;Methods;Modeling;mortality;Motility;multidisciplinary;Natural Selections;Organoids;Outcome;pathogen;pathogenic bacteria;Pathogenicity;Pathway interactions;Patient Care;Peptide Signal Sequences;Peptides;Persons;Phylogenetic Analysis;Physicians;Physiological;Preparation;pressure;prevent;Primates;Production;Public Health;Recurrence;Research;Resistance;response;Running;Sampling;Scientist;Shapes;side effect;Signal Pathway;Signal Transduction;Site;skills;Stable Disease;supportive environment;symptom treatment;targeted treatment;Testing;Training;treatment strategy;United States;uroguanylin;Variant;Water;Work;Writing

PROJECT_TITLE: Diarrheal pathogens and the evolution of intestinal signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07A-H(20)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

PHR: The Inflammatory Bowel Diseases (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), are diseases of the gastrointestinal tract that result from abnormal immune responses to luminal antigens in genetically-susceptible individuals. IBD represents a disease with among the highest hospitalization rates within military veteran populations (>100,000 hospitalizations from 1975-2006), high readmission rates with incidence of IBD are on the increase in some populations. A recent study of more than 100,000 military service members estimated the incidence of IBD to be 2-10 times greater than non-service members, with a striking relationship between IBD incidence and the number of life stressors. The studies proposed here are designed to harness information from novel inflammation-related metabolic pathways that promote tissue healing in representative models of human IBD. It is our hope that results from these studies will provide new therapeutic options for military patients with IBD.

PI_NAMEs: COLGAN, SEAN P (contact)

PROJECT_TERMS: Actins;Acute;Address;adenylate;Adherens Junction;American;Antigens;Apical;attenuation;Back;Bacteria;Brain;cell type;Cells;Cellular Metabolic Process;Colitis;Colon;Complex;Creatine;Creatine Kinase;Crohn's disease;Cytoskeleton;Defect;design;Development;Digestive System Disorders;Disease;Energy Metabolism;Environment;Enzymes;Epithelial Cells;Epithelium;Etiology;falls;Family;Flare;Flow Cytometry;Gastrointestinal Diseases;Generations;gut inflammation;healing;Hospitalization;hospitalization rates;Human;human model;Immune;Immune response;Impairment;In Vitro;in vivo;Incidence;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;Innate Immune Response;inorganic phosphate;insight;interest;intestinal epithelium;Invaded;Investigational Therapies;kinase inhibitor;knock-down;Life;Link;Location;loss of function;Maintenance;Measures;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;microbial products;military patient;military service;military veteran;Mitochondria;Molds;Molecular;mouse model;Mucositis;Mucous Membrane;murine colitis;Mus;Mutant Strains Mice;NADH;Natural Immunity;novel;novel therapeutics;Nutrient;Oxidation-Reduction;Pathway interactions;Peripheral Blood Mononuclear Cell;Phosphocreatine;Population;Predisposition;Process;Production;Protein Isoforms;readmission rates;Recombinants;Regulation;Resolution;response;Role;service member;Severity of illness;Signal Transduction;Site;Splenocyte;Stress;stressor;Supplementation;T-Lymphocyte;Testing;Therapeutic Agents;Tight Junctions;Tissues;TNF gene;Translating;Tryptophan Metabolism Pathway;Ulcerative Colitis;Western World;Work

PROJECT_TITLE: Metabolic Regulation of Mucosal Inflammation


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Colorectal Cancer;Complementary and Integrative Health;Digestive Diseases;Immunization;Immunotherapy;Liver Disease

PHR: PROJECT NARRATIVE Cancer immunotherapies have demonstrated significant clinical success for subgroups of patients with varying malignancies. However, due in part to their systemic administration, therapeutic limitations include immune- related adverse effects and diminished efficacy due to poor tumor penetration. This proposal seeks to engineer immunotherapeutic probiotic bacteria that target primary cancers and associated metastases and locally deliver immunotherapy and adjuvants to stimulate systemic antitumor immunity with minimal side effects.

PI_NAMEs: ARPAIA, NICHOLAS ;DANINO, TAL  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Adjuvant;antagonist;anti-cancer;anti-tumor immune response;Antibodies;Antigen-Presenting Cells;Area;autoimmune toxicity;Bacteria;Body Temperature;Body Weight;cancer immunotherapy;Cancer Model;cancer therapy;CD47 gene;Clinical;clinical practice;Clinical Trials;Clone Cells;colon cancer patients;Colorectal;Colorectal Cancer;colorectal cancer metastasis;Colorectal Neoplasms;Combination immunotherapy;comparative efficacy;CTLA4 gene;cytokine;Cytolysis;delivery vehicle;Distant;Dose;Dose Limiting;Engineered Probiotics;Engineering;Escherichia coli;Evaluation;Excision;exhaustion;Exhibits;Genetic Engineering;Goals;Growth;Health;Heart Rate;Hepatic;immune cell infiltrate;immune checkpoint;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;Immune Targeting;immune-related adverse events;Immunity;Immunologic Adjuvants;Immunophenotyping;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;in vivo imaging system;innovation;Intravenous;Kinetics;Lead;Lesion;Liver;Liver neoplasms;Local Therapy;Lung;Malignant Neoplasms;Measurement;metastatic colorectal;Metastatic Neoplasm to the Liver;Methods;Modality;Monitor;Monoclonal Antibodies;Monoclonal Antibody Therapy;mouse model;Mus;Mutate;Mutation;nanobodies;Necrosis;neoantigens;Neoplasm Metastasis;novel;Oral;Oral Administration;patient subsets;Patients;Penetration;prevent;Primary Neoplasm;probiotic therapy;Probiotics;Production;programmed cell death ligand 1;Recombinants;Regimen;Renaissance;Research;response;Safety;side effect;Solid Neoplasm;Specificity;success;Survival Rate;synthetic biology;System;systemic toxicity;T cell response;T-Lymphocyte;Therapeutic;Toxic effect;Treatment Efficacy;Treatment Protocols;tumor;Tumor Antigens;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Promotion;Vascularization;Work

PROJECT_TITLE: Engineering immunotherapeutic probiotics to mitigate irAE


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research;Youth Violence

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The proposed research is relevant to public health as it addresses an important gap in understanding relational health risks that affect child health and development. The purpose of this exploratory mixed-methods study is to develop knowledge of post-separation abuse and examine how post-separation abuse impacts children’s health needs and flourishing outcomes. This research is relevant to NICHD’s priority to understand the developmental impact of adverse childhood experiences, identify opportunities for intervention, and ensure that all children have the chance to live healthy, safe, and productive lives.

PI_NAMEs: SPEARMAN, KATHRYN JANE (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: Abuse Reporting;Address;Adult;adverse childhood events;Affect;Age;Area;arm;Assessment tool;Attention;Behavior;Behavioral;care systems;career;Caring;Child;Child Development;Child Health;Child Rearing;Child Welfare;Childhood;Chronic;Communities;Complex;court;Cross-Sectional Studies;Curiosities;Data;Development;Device or Instrument Development;Discipline of Nursing;discount;divorce/separation;Economics;Emotional;Emotions;Ensure;Environment;experience;Exposure to;Face;Family;Foundations;harassment;Health;health care availability;health care service;health data;health disparity;Health Professional;Health Surveys;Healthcare;Individual;innovation;interest;Intervention;Interview;intimate partner violence;Knowledge;Learning;Legal;Logistic Regressions;Measures;Methods;Minor;Modeling;Morbidity - disease rate;Mothers;National Institute of Child Health and Human Development;Outcome;outcome prediction;Pattern;Perception;Phase;Policy Maker;Prevalence;Process;Productivity;Psyche structure;Psychometrics;Public Health;recruit;Research;Research Personnel;Resources;response;Risk;Risk Assessment;Risk Factors;Safety;Sampling;Schools;Secure;Strategic Planning;Structure;Surveys;Survivors;System;Testing;Time;traumatized children;Validity and Reliability;violence exposure;Woman

PROJECT_TITLE: Understanding the Impact of Post-Separation Abuse on Children's Health and Flourishing Outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: While sexual dimorphisms have been reported in the adipose tissue’s metabolic adaptation to environmental temperature or nutritional challenges, the sex-specific mechanisms regulating adipose tissue’s responses are not fully understood. This research proposal aims to test whether estrogen-initiated ERα signaling in the ventrolateral region of the ventromedial hypothalamus contributes to sex dimorphic regulation of adipose tissue metabolic adaptation.

PI_NAMEs: TORRES IRIZARRY, VALERIA CECILIA (contact)

PROGRAM_OFFICER_NAME: BODDIE, THOMAS ARTIS

PROJECT_TERMS: Adipocytes;Adipose tissue;Brain;brain tissue;Brown Fat;Chronic;Clinical;combat;Comprehension;Data;dorsal raphe nucleus;Electrophysiology (science);energy balance;Energy Metabolism;ESR1 gene;Estradiol;Estrogens;Fasting;Fatty acid glycerol esters;Female;female sex hormone;Fiber;Functional disorder;Hypothalamic structure;Impairment;improved;in vivo;insight;male;Mediating;Metabolic;Metabolic syndrome;Metabolism;Modeling;Monitor;Mus;neural;neural circuit;neural network;Neurons;neurotransmission;Nutrient;Nutritional;Obesity;optogenetics;Output;Ovarian hormone;Ovariectomy;Pathologic;Photometry;Physiologic Thermoregulation;Physiological;Play;Property;Regulation;Reporting;Research Proposals;response;Role;sex;sexual dimorphism;Signal Transduction;Site;Structure;subcutaneous;Supplementation;Synapses;Temperature;Testing;Thermogenesis;Tracer;women versus men;Work

PROJECT_TITLE: Estrogen Signaling in the Ventromedial Hypothalamus Modulates Adipose Tissue Metabolic Adaptation


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: WASHINGTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Cardiovascular diseases present a major global public health burden. Epigenetics-based regulation of cardiac health and pathophysiology is poorly understood. This project aims to investigate the roles of epigenetic modifiers in cardiac electromechanics and to build computational models for applications in cardiac therapeutics and cardio-oncology.

PI_NAMEs: POZO, MARIA  (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Acetylation;Action Potentials;Acute;Arrhythmia;Autoimmune Diseases;Automobile Driving;Autophagocytosis;Behavior;Biological Assay;Calcium;cancer therapy;Cardiac;Cardiac Electrophysiologic Techniques;Cardiac health;cardioprotection;Cardiotoxicity;Cardiovascular Diseases;Cardiovascular system;Cell Cycle;Cells;chromatin remodeling;Complex;Computer Models;Contractile Proteins;cost estimate;CRISPR interference;CRISPR-mediated transcriptional activation;Cytoskeletal Proteins;Data;Development;disease model;Electrophysiology (science);Emergency Situation;Epigenetic Process;epigenetic regulation;epigenomics;Event;Exhibits;experience;experimental study;Feedback;Fibrosis;Frequencies;Functional disorder;Gene Expression;gene regulatory network;gene repression;Genes;Genetic Transcription;Guide RNA;Health;Heart;heart function;Heart Injuries;Histone Deacetylase;Histone Deacetylase Inhibitor;Homeostasis;Human;human induced pluripotent stem cells;Hypertrophy;Immune System Diseases;improved;Individual;induced pluripotent stem cell derived cardiomyocytes;Inflammatory Response;interest;Intervention;Ion Channel;Ischemia;knock-down;Libraries;Link;loss of function;Malignant Neoplasms;Measurement;Measures;Mechanics;Mitochondria;Modeling;Morbidity - disease rate;mortality;mouse model;novel;Oncology;Optics;Oxidative Stress;Pathology;patient prognosis;pharmacologic;Phenotype;Predisposition;Process;Proteins;Public Health;Regulation;Regulator Genes;Reperfusion Injury;Repression;Research;response;RNA Interference;Role;Sampling;screening;Shapes;Small Interfering RNA;Specificity;Stimulus;Techniques;Therapeutic;Tissues;tool;transcription factor;transcriptome sequencing;transcriptomic profiling;transcriptomics;tumor progression;United States;Validation;Variant;voltage;Work

PROJECT_TITLE: Gene Modulation of Acetylation Modifiers to Reveal Regulatory Links to Human Cardiac Electromechanics


ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE STATEMENT Strokes occur when blood flow to the brain is disrupted – a condition that is one of the leading causes of death and disability in the United States, affecting ~800,000 patients every year. It is critical therefore to gain a better understanding of scenarios involving the abrupt loss of blood flow and associated mechanisms that translate changes in physical forces into intracellular signals, especially with respect to the components of brain blood vessels, namely pericytes and endothelial cells. The ultimate goal is to identify molecular and cellular mechanisms that will inspire the design of novel stroke therapies and build upon established ones to improve patient outcomes.

PI_NAMEs: ABDELAZIM, HANAA  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Ablation;Acute;acute stroke;Address;Adjuvant;Adult;Affect;Age;Antibodies;Automobile Driving;Binding;Biological Assay;Biomechanics;Biophysics;Blood;Blood - brain barrier anatomy;Blood capillaries;Blood flow;Blood Vessels;blood-brain barrier function;Brain;brain endothelial cell;cadherin 5;Capillary Permeability;Cause of Death;CD31 Antigens;Cell Communication;Cell Physiology;Cells;central nervous system vasculature;cerebral microvasculature;Cerebrospinal Fluid;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular system;clinically significant;Coagulation Process;confocal imaging;Cues;Data;design;Development;disability;Disease;Economic Burden;Effectiveness;Embryonic Development;Endothelial Cells;Extracellular Matrix;Face;Gene Expression;Glucose;Goals;Health;hemodynamics;Hemorrhage;Homeostasis;Human;Hypoxia;Image;Impairment;improved;improved outcome;in vivo;in vivo Model;Incubated;Individual;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injections;Integrin Inhibition;Intercellular Junctions;Interleukin-1 beta;Ischemic Stroke;ITGA5 gene;Knowledge;laboratory experience;Lasers;Legal patent;Lentivirus;Life;Link;long term recovery;Measures;mechanical signal;Mechanics;Mediating;Metabolic;Microcirculation;Modeling;Molecular;Molecular Analysis;Morphology;Mus;next generation;novel;novel therapeutics;Organ;overexpression;particle;Patient-Focused Outcomes;Patients;Perfusion;Pericytes;pharmacologic;Phase;Physiology;Population;postnatal;Preparation;prevent;Process;Protein Biosynthesis;Proteins;public health relevance;receptor;Recovery;Reperfusion Therapy;Reporter;response;Risk;Scanning Electron Microscopy;Signal Transduction;Signaling Protein;Slice;Small Interfering RNA;Societies;Stroke;stroke patient;stroke therapy;Technology;Testing;Thrombectomy;thrombolysis;Thrombus;Time;Tissues;tool;Translating;United States;Up-Regulation;Vascular System;vector;Vitronectin

PROJECT_TITLE: The Effect of Blood Flow Changes in Brain Microvasculature on Pericyte-Endothelial Cell Interaction


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Infectious Diseases;Prevention;Urologic Diseases;Women's Health Research

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Project Narrative Risk factors for breast cancer, the second most lethal cancer in American women, require identification and further study. This project will investigate a link between the whole-body response to urinary tract infection and the development of breast cancer. This proposal represents an opportunity for improved disease prevention and targeted therapy.

PI_NAMEs: LEWIS, STEVEN MACAULEY (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: American;Antibody Formation;Antigens;B-Lymphocyte Subsets;B-Lymphocytes;Biological Assay;Biological Markers;Biological Models;biomarker development;BRCA1 gene;BRCA1 Mutation;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Prevention;Breast Cancer Risk Factor;Breast Cancer Treatment;Breast Epithelial Cells;cancer risk;cancer stem cell;career;Cell Communication;Cell Physiology;Cell Separation;Cell surface;Cells;clinically relevant;Coculture Techniques;Color;Counseling;demographics;Development;differential expression;disorder prevention;DNA Repair Gene;early detection biomarkers;Early treatment;Epigenetic Process;Epithelial Cells;Epithelium;Event;Exhibits;experience;experimental study;Extracellular Matrix;Family;Fibroblasts;Flow Cytometry;Foundations;Future;gene environment interaction;Genetic;Germ-Line Mutation;Gland;Goals;Histopathology;Immune;Immune system;Immunization;improved;in vivo evaluation;Incidence;Infection;Inflammation;Knock-out;Knockout Mice;Laboratory Finding;Life;life history;Life Style;Link;loss of function;loss of function mutation;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;mammary epithelium;Mammary gland;Mammary Tumorigenesis;Mature B-Lymphocyte;Medical History;Molecular;Mus;Mutation;mutation carrier;novel;Organoids;Outcome;Ovum;Pathway interactions;Patients;Physicians;Play;Population;Pregnancy;Prevention;Prevention therapy;Research;response;Risk;Risk Assessment;Risk Factors;Role;Scientist;Signal Transduction;single-cell RNA sequencing;Solid Neoplasm;System;targeted treatment;Testing;Tissues;Training;transcriptome;Transplantation;tumor;Tumor Expansion;tumor growth;tumor initiation;tumor microenvironment;tumor progression;tumorigenesis;tumorigenic;Urinary tract infection;Woman;Work

PROJECT_TITLE: Investigating the relationship between the systemic response to infection and tumor initiation and progression in Brca1 breast cancer