ADMINISTERING_IC: MH

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Top-down signals from higher-order cortical areas are crucial for appropriate cognitive control of sensory processing, behavior, and learning. Top-down processing is profoundly disrupted across a range of disease states including schizophrenia, autism spectrum disorder, addiction, and dementia. Here we simultaneously record somatic and dendritic activity in large networks of neurons to reveal how top-down inputs control learning, thereby providing general mechanistic principles for how cortex ultimately produces the computations that guide behavior.

PI_NAMEs: HARNETT, MARK THOMAS (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TERMS: addiction;Address;Anatomy;Animals;Apical;Area;area striata;artificial neural network;Attention;autism spectrum disorder;Behavior;Behavioral;behavioral study;Biological;biological systems;Brain;brain computer interface;Cells;Cognition;cognitive control;comparative;Complement;Complex;cost;Cost Control;Data;Dementia;Dendrites;Disease;Down-Regulation;Educational process of instructing;experimental study;Generations;Head;Image;imaging approach;in vivo;Individual;insight;Label;Learning;Link;Maps;Measurement;Mediating;multisensory;Mus;neural;neuronal cell body;Neurons;neuroregulation;novel;novel strategies;Paper;Patients;Pattern;Play;Population;Preparation;prevent;Process;Role;Schizophrenia;Sensory;sensory integration;Signal Transduction;Slice;spatiotemporal;Specific qualifier value;Synapses;Synaptic plasticity;Testing;theories;Thinking;Time;translational potential;two-photon;vector;virtual

PROJECT_TITLE: The role of top-down dendritic processing in credit assignment and cortical dynamics

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative Targeting RAS-mutant tumors using RAF and MEK inhibitors has shown preclinical promise, but only modest results in the clinic. Our preliminary data indicate that the extent of tumor-selective inhibition of MAPK signaling by these drugs is determined by paralog and conformation selectivity of different biochemical classes of RAF and MEK inhibitors. This proposal is aimed at elucidating mechanisms determining tumor-selective potency of RAS pathway inhibitors to enable the design of more effective therapies for RAS-mutant cancers.

PI_NAMEs: POULIKAKOS, POULIKOS I (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Affect;Binding;Biochemical;Biological Assay;biophysical techniques;Biophysics;Body Weight decreased;BRAF gene;cell growth;cell type;Cells;Clinic;Clinical;clinical efficacy;Combined Modality Therapy;Complex;Data;design;dimer;Dose Limiting;Drug Combinations;Drug Targeting;drug-sensitive;effective therapy;Effectiveness;experience;experimental study;Generations;Goals;in vivo;inhibitor;insight;Link;Malignant Neoplasms;MAP Kinase Gene;MEKs;Modeling;Molecular Conformation;monomer;Mus;mutant;Mutation;Normal Cell;Normal tissue morphology;Oncogenic;paralogous gene;Pathway interactions;Pharmaceutical Preparations;posttranscriptional;pre-clinical;programs;protein expression;Proteins;Ras/Raf;rational design;Regulation;Research;Resistance;response;Signal Pathway;Signal Transduction;small molecule inhibitor;targeted treatment;Testing;Therapeutic;therapeutically effective;tool;Toxic effect;tumor;Up-Regulation

PROJECT_TITLE: Mechanisms determining tumor-selective potency of RAS pathway inhibitors

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative The proposed research is relevant to public health because developing novel acid ceramidase inhibitors will improve our ability to halt disease progression among patients with chronic liver disease. Thus, the proposed project is relevant to the NIH’s mission to seek and apply knowledge to lengthen life and reduce illness.

PI_NAMEs: JO, HYUNIL  (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Active Sites;acute toxicity;Address;Affect;American;Biochemical;Biological Assay;Biological Availability;Biological Markers;Carbon Tetrachloride;Cells;Ceramides;Cessation of life;Chemicals;Cholesterol;chronic liver disease;Cirrhosis;Collaborations;Cysteine;cytotoxicity;Derivation procedure;Development;developmental disease;Disease Progression;Dose;Drug Design;drug development;Drug Kinetics;effective therapy;end stage liver disease;Enzyme Inhibition;Enzymes;Farber's lipogranulomatosis;FDA approved;fibrogenesis;Fibrosis;Fructose;galactosylgalactosylglucosylceramidase;Genetic;genetic signature;Goals;Half-Life;Hepatic Fibrogenesis;Hepatic Stellate Cell;Hour;Human;human model;Hydrolysis;improved;In Vitro;in vivo;Inflammation;inhibitor;Intervention;Intraperitoneal Injections;Knock-out;Knowledge;Lead;lead optimization;lead series;Life;Liver;Liver Failure;Liver Fibrosis;Measures;Medical;Medicine;Metabolic;Mission;Modeling;mouse model;nanomolar;nonalcoholic steatohepatitis;novel;novel therapeutic intervention;Oral;Outcome;Palmitates;Pathway interactions;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology Study;Plasma;preclinical study;prevent;Property;Public Health;Rattus;Research;Research Personnel;Roentgen Rays;Safety;Series;Slice;small molecule;Solubility;Specificity;Structure;Therapeutic;Tissues;Toxic effect;Trans Fats;treatment strategy;United States National Institutes of Health;virtual screening;Work

PROJECT_TITLE: Targeting Acid Ceramidase for Hepatic Fibrogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (81)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Neurosciences;Telehealth

ORG_DEPT: NEUROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The integration of biomarker guidance with transcranial direct current stimulation (tDCS) could individualize and optimize dosing to improve its clinical utility. We propose to develop a tDCS system that includes the collection of the nonspecific biomarker of heart rate variability (HRV), by validating impedance-based heart rate (i-HR) and its clinical response to tDCS intervention in adults with depression. With the advantage of home-based data collection, this proposal rigorously builds a breakthrough system that includes wearable neuromodulation and monitoring of vital signs linked to brain health.

PI_NAMEs: PILLONI, GIUSEPPINA  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, KRISTIN HEDGEPATH

PROJECT_TERMS: Acceleration;Adoption;Adult;Anodes;Applied Research;Area;Biological Markers;Biological Sciences;biomarker validation;Biomedical Engineering;brain health;Central Nervous System;Chest;Clinical;clinical application;clinical efficacy;clinical practice;Clinical Trials;Collaborations;Collection;Data;Data Collection;depressive symptoms;design;Development;Devices;digital;digital health;disparity reduction;Distress;Dose;efficacy trial;electric impedance;Electrocardiogram;Equipment and supply inventories;flexibility;Frequencies;Goals;health care availability;health care disparity;Heart Rate;heart rate monitor;heart rate variability;Home;improved;Individual;Individual Differences;individualized medicine;innovation;Intervention;Left;Level of Evidence;Link;Machine Learning;Measurement;Measures;Mental Depression;Methods;Modeling;Monitor;multidisciplinary;neurofeedback;neuropsychiatric symptom;neuropsychiatry;neuroregulation;noninvasive brain stimulation;novel;Output;Participant;Patient Self-Report;Patients;physical science;Pilot Projects;Prefrontal Cortex;premature;Procedures;Protocols documentation;Randomized;recruit;remote therapy;response;Sampling;secondary analysis;signal processing;Signal Transduction;Symptoms;System;targeted biomarker;Techniques;Technology;telehealth;teleintervention;therapeutic development;Time;tool;transcranial direct current stimulation;Translating;treatment response;United States National Institutes of Health;Validation;videoconference;wearable device;Work

PROJECT_TITLE: HRV-guided tDCS: Integrating a biomarker for clinical utility

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-Q (91)]


ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Immunotherapy has become a standard therapy for many cancers, but it is associated with a risk of acute kidney injury, resulting in significantly increased mortality. Overall goal of this study is to delineate the roles of antigen-specific T cells in immunotherapy-associated acute kidney injury, using novel animal models. The study will lead to better understanding of the mechanisms of immunotherapy-associated kidney injury and identification of potential therapeutic targets.

PI_NAMEs: MURAKAMI, NAOKA  (contact)

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;adaptive immune response;Adrenal Cortex Hormones;Adverse event;Affect;Animal Model;anti-CTLA4 antibodies;anti-PD-1;antigen-specific T cells;Antigens;Autoantigens;Autoimmune;Autoimmunity;Biopsy Specimen;cancer therapy;Cardiac Myosins;CD8-Positive T-Lymphocytes;Cells;Characteristics;chemokine;Chronic;Chronic Kidney Failure;Clinical;Clinical Trials;CTLA4 gene;CXCL10 gene;CXCR3 gene;Data;effector T cell;Eligibility Determination;End stage renal failure;Fibrosis;FRAP1 gene;genetic manipulation;Glomerulonephritis;Goals;Heart;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune response;Immune Tolerance;Immunobiology;immunogenic;Immunologics;Immunosuppression;Immunotherapy;improved;Infection;Infiltration;Inflammation;Inflammatory;inhibitor;Injury to Kidney;innovation;insight;Interstitial Nephritis;Kidney;kidney biopsy;Kidney Diseases;Knowledge;Lymphocyte;lymphocyte trafficking;Malignant Neoplasms;MC38;Melanoma;Membranous Glomerulonephritis;Memory;Modeling;mortality;mouse model;Mus;Myocarditis;new therapeutic target;novel;Pathway interactions;Patient-Focused Outcomes;Patients;peripheral blood;Pharmaceutical Preparations;Phenotype;Play;prevent;programmed cell death protein 1;progression risk;Regulatory T-Lymphocyte;renal damage;Renal tubule structure;response;Risk;Role;Self Tolerance;Series;Signal Pathway;Signal Transduction;T cell infiltration;T-Cell Receptor;T-Lymphocyte;Tamoxifen;targeted treatment;therapeutic target;Tissues;trafficking;transcriptomics;tumor

PROJECT_TITLE: Antigen-specific T cells in immunotherapy-associated acute kidney injury

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: CHAPEL HILL

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Due to recent changes in state reproductive health policy landscapes, U.S. obstetrician- gynecologists may experience policy-related stressors and threats to their mental health and wellbeing. This study will produce novel evidence about the effects of state reproductive health policies on obstetrician-gynecologists’ work experiences, mental health, and work-related wellbeing, a nd will identify organizational-level policies and practices that may buffer the effects of policy stressors. By generating actionable recommendations to improve work-related stressors for obstetrician-gynecologists, the study will lead to improvements in the mental health and work-related wellbeing of this essential workforce.

PI_NAMEs: BUCHBINDER, MARA HELENE (contact);SABBATH, ERIKA LEHR

PROGRAM_OFFICER_NAME: LIOCE, MARIA

PROJECT_TITLE: Mental health and work-related wellbeing of U.S. obstetrician-gynecologists in a shifting policy climate

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Genetics;Immunotherapy;Pancreatic Cancer;Rare Diseases

ORG_CITY: Columbus

ORG_DEPT: SURGERY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The presence of tertiary lymphoid structures (TLS) in solid tumors is prognostic for survival in cancer patients, including pancreatic ductal adenocarcinoma, associated with the expression of MHCI-neoantigens and markers of enhanced immune memory. However, there is no evidence that TLS directly augment tumor specific T cell immunity or the mechanisms of how this occurs. We hypothesize that TLS in pancreatic tumors promote the differentiation of stem-like T cells through IL-21 programming, thereby enhancing effector T cell responses leading to improved tumor control.

PI_NAMEs: GUNDERSON, ANDREW  (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Ablation;Address;Adoptive Transfer;Agonist;Algorithms;Anti-CD40;anti-PD-1;Antibodies;Antigen-Presenting Cells;Antigens;B-Lymphocytes;Biological Process;Biology;Blood;Cancer cell line;Cancer Patient;cancer type;CD44 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Differentiation process;Cell Line;Cell Lineage;Cell Physiology;Cells;Cellular Immunity;Chimeric Proteins;Chronic;chronic infection;Collaborations;Complement;computer framework;Data;design;Development;draining lymph node;driver mutation;effector T cell;Fc Receptor;Fibroblasts;Flow Cytometry;Fourier Transform;Frequencies;Gene Modified;Generations;Genes;Genetic;genetic signature;Genomics;Graph;Helper-Inducer T-Lymphocyte;High Endothelial Venule;Human;Immune;immune activation;immune checkpoint blockade;immune function;Immunity;Immunofluorescence Immunologic;Immunologic Memory;Immunologics;immunoreaction;Immunotherapy;implantation;improved;In Situ;innovation;insight;interleukin-21;interleukin-21 receptor;Knockout Mice;KRAS oncogenesis;LoxP-flanked allele;Luciferases;lymph nodes;Lymphatic;lymphotoxin beta receptor;Maintenance;Malignant Neoplasms;Mediating;Memory;Methods;Modeling;Molecular;mouse model;multidisciplinary;Mus;mutant;Mutation;neoantigens;novel;Operative Surgical Procedures;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic neoplasm;Pathway interactions;Patients;Peripheral;permissiveness;Phenotype;pre-clinical;predicting response;Primary Neoplasm;prognostic;prognostic of survival;programmed cell death protein 1;Publishing;Reaction;Reporter;Reporting;Research;Resected;Residencies;Resistance;response;Role;Sampling;SELL gene;Signal Transduction;SIYRYYGL;Solid Neoplasm;Spleen;stem;Structure of germinal center of lymph node;T cell differentiation;T cell response;T memory cell;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;tertiary lymphoid organ;Testing;Time;tissue biomarkers;Tissues;TP53 gene;transcriptomics;Transgenic Mice;Translating;tumor;Tumor Antigens;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Promotion;tumorigenesis;Work

PROJECT_TITLE: ROLES AND MECHANISMS OF TERTIARY LYMPHOID STRUCTURES IN ANTI-TUMOR IMMUNITY

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-Q (80)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Biotechnology

ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE Each cell in the human body experiences aging and its related-diseases differently. This application proposes novel single-cell methodologies using mass cytometry to explore the molecular foundations of aging to inform the design and development of future treatments.

PI_NAMEs: ARRIAGA, EDGAR A (contact);DISTEFANO, MARK D

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: age effect;Aging;analog;Antibodies;Autophagocytosis;Bar Codes;Biological Aging;Biological Assay;Biological Monitoring;Biological Process;Biotechnology;Cell Aging;cell fixation;Cell Survival;cell type;Cells;Characteristics;Cytometry;design;Detection;Development;Disease;DNA;experience;Foundations;Future;Goals;Heterogeneity;Homeostasis;Human body;Image;imaging modality;Individual;Isotopes;Label;Lanthanoid Series Elements;Life;Ligands;Ligation;Link;Liver;liver function;Location;Messenger RNA;Metabolic;Metabolism;Metals;meter;Methodology;Methods;mevalonate;Modeling;Molecular;Molecular Probes;Molecular Target;Monitor;Multiplexed Ion Beam Imaging;Mus;novel;Organism;Pathway Analysis;Pathway interactions;Post-Translational Protein Processing;prenylation;Process;Property;Protein Biosynthesis;Proteins;rational design;Reporter;response;RNA;Sample Size;Sampling;self assembly;senescence;senescent cell;single cell analysis;single cell technology;siRNA delivery;Stains;System;T-DNA;Techniques;therapy design;Time;Tissues;Work

PROJECT_TITLE: Single-Cell Molecular Pathway Analysis in Aging Systems via Novel Mass Cytometry Methods

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Diabetes;Genetics;Human Genome;Obesity

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Insulin resistance (IR) is a common and increasing health problem that precedes development of type 2 diabetes and causes cardiovascular disease, but its genetic determinants are largely unknown. We will combine innovative methods including colocalization studies followed by single cell transcriptomics and single cell epigenomics to establish causal genes and mechanisms of action for novel genes involved in development of IR, and validate the physiological role of causal genes in vitro and in vivo using mouse models in a fat-depot specific way. Our work will lead to mechanistic insights into the development of IR and to better treatments for IR and related conditions.

PI_NAMEs: KNOWLES, JOSHUA WILEY (contact)

PROGRAM_OFFICER_NAME: ZAGHLOUL, NORANN

PROJECT_TERMS: Address;adenovirus mediated delivery;Adipocytes;Adipose tissue;Affect;ATAC-seq;blood glucose regulation;Body mass index;Cardiovascular Diseases;cardiovascular disorder risk;causal variant;Cell Nucleolus;Cell Nucleus;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Computer Analysis;cost effective;Coupling;CRISPR interference;Custom;Data;Data Set;Development;Disease;Disease Clusterings;drug development;Drug Targeting;Enterobacteria phage P1 Cre recombinase;epigenome;epigenomics;Fasting;fasting glucose;Fatty acid glycerol esters;Fibroblasts;Functional disorder;functional genomics;gene regulatory network;Genes;Genetic;Genetic Determinism;genome wide association study;genomic locus;genomic tools;Genotype;Genotype-Tissue Expression Project;glucose metabolism;glucose uptake;GLUT 4 protein;Health;High Density Lipoprotein Cholesterol;Human;human disease;Human Genetics;In Vitro;in vivo;Injections;innovation;insight;Insulin;Insulin Resistance;knock-down;lipid biosynthesis;Lipolysis;Liver;loss of function;Macrophage;Maps;Measures;Mediating;Metabolic;Methods;Mitochondria;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;multi-ethnic;Mus;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;Pancreas;pandemic disease;Pathway interactions;Phenotype;Physiological;Predisposition;Public Health;Quantitative Trait Loci;resistance gene;resistance mechanism;Risk Factors;RNA Splicing;Role;Sampling;Signal Transduction;single cell analysis;single cell ATAC-seq;single-cell RNA sequencing;Skeletal Muscle;Structure;subcutaneous;Susceptibility Gene;System;Testing;Therapeutic;therapeutic target;Time;Tissues;trait;transcriptome;transcriptome sequencing;transcriptomics;Translating;Triglycerides;Visceral;Waist-Hip Ratio;Work

PROJECT_TITLE: Molecular Mechanisms of Insulin Resistance Associated Loci

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Cancer;Uterine Cancer;Women's Health Research

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Linda Duska, MD, MPH is an experienced and prolific Clinical Scientist whose overall research goal is to improve the lives of patients with gynecologic cancer and other solid tumors by offering opportunities to participate in clinical research and by developing novel biomarker driven therapies through the clinical trial mechanism. The goal of this proposal is to increase both overall accrual and diversity of accrual to nationally sponsored clinical trials at the University of Virginia Comprehensive Cancer Center (UVACCC) and to increase UVA’s leadership and collaboration in new clinical trials within the national framework. These goals overlap with the goals of the UVACCC, which include increasing accrual and diversification, as well as building multi- disciplinary teams focused on a biomarker-driven approach to clinical research.

PI_NAMEs: DUSKA, LINDA  (contact)

PROGRAM_OFFICER_NAME: MAHER, MOLLY ELIZABETH

PROJECT_TERMS: Award;biomarker driven;chemotherapy;Clinical;Clinical Research;Clinical Trials;Collaborations;Comprehensive Cancer Center;Development;Early Therapeutic-Clinical Trials Network;experience;Female Genital Neoplasms;Goals;Gynecologic Oncologist;Gynecologic Oncology;improved;Infrastructure;Institution;Lead;Leadership;Maintenance;Malignant Female Reproductive System Neoplasm;medical schools;Mentors;Mentorship;multidisciplinary;novel marker;Operative Surgical Procedures;patient-level barriers;Patients;Positioning Attribute;Principal Investigator;programs;provider-level barriers;Research;Research Infrastructure;Research Personnel;Role;Schools;Scientist;Solid Neoplasm;translational scientist;Universities;Virginia;Woman

PROJECT_TITLE: Enhancing accrual and diversity across gynecologic and solid tumor trials

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-1 (O1)]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Childhood Obesity;Clinical Research;Nutrition;Obesity;Pediatric;Physical Activity;Sleep Research

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: The combination of heart rate and accelerometry provides better estimates of energy expenditure and sleep compared to either metric alone, but current wearable devices that measure both heart rate and acceleration are not designed for children and may be distracting or uncomfortable. Furthermore, current wearable devices use proprietary processing techniques, which means they cannot be truly validated. Therefore, our research team has created and calibrated an open-source wearable PATCH device designed to measure heart rate and acceleration among children 3-8, and the current project will develop and validate open-source algorithms to predict energy expenditure and sleep among children in both laboratory and free-living contexts.

PI_NAMEs: ARMSTRONG, BRIDGET R. (contact)

PROGRAM_OFFICER_NAME: BROWN, ALISON GWENDOLYN MARY

PROJECT_TERMS: 8 year old;Acceleration;Accelerometer;Age;aged;Algorithms;Assessment tool;Behavior;Calibration;Cardiovascular Diseases;Caring;Child;Complex;Data;design;Detection;Development;Device Designs;Devices;Diabetes Mellitus;energy balance;Energy Metabolism;Epidemiology;epidemiology study;Equation;Expenditure;fitbit;free behavior;Goals;Health;Heart Rate;Hour;improved;Indirect Calorimetry;innovation;Intervention;Intervention Studies;Laboratories;Maintenance;Measurement;Measures;Methods;Monitor;Movement;Obesity;Observational Study;open source;Outcome;Photoplethysmography;Polysomnography;Process;Research;Research Personnel;Resistance;Sampling;sedentary;sensor;Series;Signal Transduction;Skin;Sleep;Sleep Stages;Techniques;Technology;Time;validation studies;Water;wearable device;Work

PROJECT_TITLE: Using Open-Source Technology to Measure Energy Expenditure and Sleep Among Children 3 to 8 Years Old

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_DEPT: GENETICS

PHR: NARRATIVE Single-cell methods for assaying RNA, chromatin state, protein abundance, and other molecular features are becoming increasingly common means to investigate biological phenomena, especially in complex, heterogeneous tissues. However, while single-cell data sets are being generated rapidly, creating a massive corpus of single-cell data across multiple measurement modalities, computational methods for interpreting these large-scale data and extracting biological insights from these rich, diverse data modalities are lagging behind the molecular methodological advances that have enabled this prodigious data generation. In this proposal, we aim to address this critical need of the field by further extending a widely used analysis platform, ArchR, to 1) further improve performance on large data sets, 2) elegantly interpret and explore multi-modal data sets from diverse cellular assays, and 3) deploy cutting-edge deep learning platforms to use single-cell data sets to link regulatory activities to individual bases in the genome.

PI_NAMEs: GREENLEAF, WILLIAM JAMES (contact)

PROGRAM_OFFICER_NAME: DI FRANCESCO, VALENTINA

PROJECT_TERMS: Address;Algorithms;analytical tool;Architecture;ATAC-seq;Atlases;base;Base Pairing;Base Sequence;Benchmarking;Biological;Biological Assay;Biological Phenomena;Biological Process;Cell model;cell type;Cells;Cellular Assay;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;commercialization;Communities;Complex;Complex Analysis;Computer Hardware;computer infrastructure;Computer software;Computing Methodologies;cost;Data;Data Compression;Data Linkages;data modalities;Data Set;Data Storage and Retrieval;data streams;de novo mutation;deep learning;deep learning model;deep neural network;design;Development;Disease;diverse data;DNA Sequence;Ecosystem;Engineering;Enhancers;Excision;Feedback;functional genomics;Future;Gene Expression;Gene Expression Profiling;Generations;Genetic Research;Genetic Variation;Genome;genome sequencing;genome wide association study;Genomics;Goals;Health;Heterogeneity;Human;human disease;Human Genetics;improved;Individual;Infrastructure;insight;interest;Joints;Laboratories;large datasets;large scale data;Learning;Libraries;Lifting;Link;Literature;Machine Learning;Measurement;Membrane Proteins;Memory;Methodology;Methods;Modality;Modeling;Molecular;multimodal data;multimodality;Multiomic Data;multiple omics;Nature;operation;Performance;Play;predictive modeling;Process;Proteins;Regression Analysis;Research Personnel;Resolution;Resources;RNA;Running;Sampling;single cell analysis;single cell ATAC-seq;single cell genomics;single cell technology;software development;Software Tools;Stream;Structure;System;Technology;Time;Tissues;tool;Training;transcriptome sequencing;Untranslated RNA;usability;user friendly software;user-friendly;Variant;Visualization;web portal;whole genome;Work

PROJECT_TITLE: Fast, powerful, scalable, usable, and distributable methods for multi-modal single cell analyses

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biotechnology;Brain Disorders;Dementia;Immunotherapy;Neurodegenerative;Neurosciences

PHR: NARRATIVE: Recent FDA conditional approvals of two anti-amyloid antibody treatments for early-stage Alzheimer’s disease provide the first disease-modifying treatments to date, albeit with modest-to-moderate slowing of cognitive decline and vascular side effects. Here, we will test the efficacy of a Glucagon-Like Peptide 1 Receptor (GLP- 1R) agonist, semaglutide, a drug with strong anti-inflammatory, neuroprotective and pro-vascular health effects that is FDA approved for type 2 diabetes and obesity, both alone and in combination with anti-amyloid antibodies in mouse models of Alzheimer’s disease. We hypothesize that the combination therapy will enhance the efficacy beyond that of either treatment alone, and attenuate the vascular side effects seen with anti-amyloid antibodies.

PI_NAMEs: LEMERE, CYNTHIA A (contact)

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: Acceleration;Acute;Aducanumab;Age;aged;Aging;Agonist;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid;Amyloid beta-Protein;analog;Anti-Inflammatory Agents;Antibodies;antibody immunotherapy;Antibody Therapy;apolipoprotein E-4;APP-PS1;Attenuated;Behavior;Behavior Control;behavior test;Binding;Biochemical;Biochemistry;Blood;Blood Vessels;Brain;Brain Pathology;Cells;Cerebrovascular system;chemokine;Cholesterol;Clinical;Clinical Trials;Cognition;Cognitive;Combined Modality Therapy;comparative efficacy;Complement;cytokine;Data;Diabetes Mellitus;dimer;Disease;disease model;Dose;Drainage procedure;Early treatment;Edema;efficacy testing;Electrophysiology (science);Euthanasia;FDA approved;Female;fluorescein isothiocyanate dextran;Gliosis;GLP-I receptor;Glucagon;Glucose;Goals;Health;Hemorrhage;Hippocampus;Human;human data;IgG2;Image;Immune;Immunotherapy;Impaired cognition;improved;Inflammation;Injections;Knock-in Mouse;Laboratories;Lead;male;Maps;Measures;Mediating;Modeling;mouse model;Mus;mutant;Nerve Degeneration;Neurons;neuroprotection;Non-Insulin-Dependent Diabetes Mellitus;Obesity;old mice;Outcome;overexpression;Pathologic;Pathology;Patients;Pharmaceutical Preparations;Phase;Phase III Clinical Trials;Phenotype;Physiological;Plasma;Population;Prevention;Proteins;receptor;Reporting;Safety;side effect;single nucleus RNA-sequencing;stroke model;Subcutaneous Injections;Synapses;Testing;Therapeutic;Time;Titrations;Toxic effect;transcriptome sequencing;transcriptomics;United States National Institutes of Health

PROJECT_TITLE: Combination Therapy with Semaglutide and Anti-Amyloid Antibodies for Alzheimers Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-G (O1)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Genetics;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE In hampered acquired will features used contrast to rain magnetic resonance images acquired in research settings, technical obstacles have to date  our ability to extract valuable quantitative information from the vast amounts of brain imaging data in clinical pediatric settings. Leveraging a recently validated computational approach, this proposal generate brain growth chart models that allow accurate, quantitative benchmarking of brain morphological from clinically-acquired brain scans. Newly extracted i nformation from clinically-acquired scans will be to identify brain neuroanatomical profiles associated with b high genetic risk for neurodevelopmental disorders and behavioral health outcomes.

PI_NAMEs: ALEXANDER-BLOCH, AARON FELIX (contact)

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: Age;Anatomy;autism spectrum disorder;behavioral health;behavioral phenotyping;Benchmarking;biobank;Brain;Brain imaging;brain magnetic resonance imaging;brain morphology;Brain region;Brain scan;brain volume;Caring;Child;Childhood;Clinical;cohort;community research;comparison control;Computer Models;Copy Number Polymorphism;Craniocerebral Trauma;Data;Data Set;deep learning;Development;Electronic Health Record;Ensure;Environmental Exposure;Future;Genes;Genetic;Genetic Risk;Growth;Headache;Health Insurance Portability and Accountability Act;Health system;high risk;Hospitals;Image;image processing;imaging genetics;imaging Segmentation;Individual;individual patient;Infrastructure;Institutional Review Boards;interest;Investigation;Magnetic Resonance Imaging;Maps;Measures;Methodology;Modeling;Molecular;Nature;Neuroanatomy;neurodevelopment;Neurodevelopmental Disorder;neurogenomics;neuroimaging;neuroinformatics;neuropsychiatric disorder;neuropsychiatry;Outcome;Participant;Pathology;Pathway interactions;patient privacy;Pattern;Pediatric Hospitals;Phenotype;Philadelphia;polygenic risk score;Population;Procedures;Properdin;prospective;Protocols documentation;Psychiatry;Psychopathology;Psychoses;Quality Control;Radiology Specialty;radiomics;Rain;rare variant;Recommendation;Records;recruit;Reproducibility;Research;Research Personnel;research study;Resource Sharing;Resources;risk variant;Sample Size;Sampling;Scanning;Science;secondary analysis;Site;SNP array;Statistical Models;Structure;Symptoms;Testing;tool;Trauma;trend;Variant;Work;Youth

PROJECT_TITLE: Radiomics for Clinically-Acquired Brain MRIs of Youth with Neurodevelopmental Disorders

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]


ORG_CITY: LOS ANGELES

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Relevance statement Perseverative and repetitive behaviors accompany multiple psychiatric disorders and require cellular and molecular level understanding in order to develop novel disease modifying therapeutic strategies. We discovered that a specific population of astrocytes in the striatum regulate neurons to cause perseverative and repetitive behavioral phenotypes in mice. We will explore how this happens and thus provide potentially new astrocyte and neuronal targets for therapeutic and diagnostic strategies.

PI_NAMEs: KHAKH, BALJIT  (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Address;Affect;Anatomy;Animal Behavior;Area;Astrocytes;Autopsy;awake;Basal Ganglia;Basal Ganglia Diseases;Behavior;Behavioral;behavioral phenotyping;Cell Nucleus;Cells;Corpus striatum structure;CRISPR/Cas technology;crystallin mu;Crystallins;Data;diagnostic strategy;Disease;Electrophysiology (science);Evaluation;Excision;experimental study;fascinate;frontier;Gene Expression;Genes;Genetic;Goals;Homeostasis;Image;in vivo;in vivo imaging;Individual;innovation;Investigation;Ions;Location;Mediating;Mental disorders;Methods;Molecular;molecular dynamics;Motor;motor behavior;motor control;multiple omics;Mus;neural;neural circuit;Neuroglia;Neurons;Neurotransmitters;neurovascular coupling;novel;Output;Phenotype;Physiological;Population;Property;protein expression;Proteins;Proteomics;repetitive behavior;Reporting;Research;Rest;Role;Synapses;Synaptic Transmission;synaptogenesis;targeted treatment;Therapeutic;Tissues;transcriptome sequencing

PROJECT_TITLE: Functions and mechanisms of a subpopulation of striatal astrocytes

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Digestive Diseases - (Peptic Ulcer);Genetics;Infectious Diseases

ORG_CITY: WASHINGTON

ORG_NAME: HOWARD UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative Inflammation associated diseases have been recognized as the most significant public health problem, not only in the United States but also worldwide. This work will provide mechanistic insight to link defects in DNA polymerase beta to mitochondrial dysfunction and cytosolic nucleic acid signaling in Helicobacter pylori associated inflammation. An understanding the ways of extracellular bacterial infections triggers cytosolic surveillance mediated inflammatory response may reveal new therapeutic possibilities for the future.

PI_NAMEs: KIDANE MULAT, DAWIT  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Acceleration;Adaptor Signaling Protein;Anti-Bacterial Agents;Attenuated;Bacteria;Bacterial Infections;base;Base Excision Repairs;Cell Nucleus;Cell Physiology;Cells;chronic inflammatory disease;Critical Pathways;Cyclic GMP;Cytoplasm;Cytosol;Data;Defect;Disease;DNA;DNA Adducts;DNA biosynthesis;DNA Damage;DNA lesion;DNA Ligation;DNA Polymerase β;DNA receptor;DNA Repair;DNA Repair Gene;DNA Repair Pathway;Double-Stranded RNA;ds-DNA;Epithelial Cells;Excision;Exhibits;experimental study;extracellular;Future;Gastritis;Genes;Goals;Helicobacter Infections;Helicobacter pylori;Homeostasis;Human;human disease;Immune;Immune response;Immune signaling;Immunity;Immunotherapeutic agent;Impairment;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;inorganic phosphate;insight;Interferons;Lead;Left;Lesion;Ligand Binding;Ligation;Link;Lyase;macromolecule;Maintenance;malignant stomach neoplasm;Mediating;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Modeling;Molecular;Mus;Nature;Nitrogen;novel;novel therapeutics;Nuclear;Nuclear Proteins;Nucleic Acids;oxidative DNA damage;Oxygen;pathogen;Pathway interactions;Pattern recognition receptor;Point Mutation;Polymerase;prevent;Proteins;Public Health;Publishing;Reactive Nitrogen Species;Reactive Oxygen Species;receptor;receptor binding;Refractory;repair enzyme;repaired;Research;response;Risk Factors;RNA;Role;sensor;Severities;Shapes;Signal Transduction;Signaling Protein;Site;Source;Stimulator of Interferon Genes;Stomach;Testing;Tissues;Tretinoin;United States;Viral;Work

PROJECT_TITLE: Linking defects in DNA polymerase beta to mitochondrial dysfunction and cytosolic nucleic acid sensor in Helicobacter pylori associated inflammation

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Biotechnology;Lung;Orphan Drug;Pulmonary Hypertension;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: NARRATIVE  Excessive vascular remodeling is a major disease feature of pulmonary arterial hypertension, but how pericytes are involved in capillary remodeling is unclear. We show for the first time that lung pericyte dysfunction reduces distal vessels and increases vessel muscularization in severe pulmonary hypertension. Through a combination of established cellular assays, novel transgenic mouse models and cutting-edge stem cell-derived culturing techniques, we will demonstrate the essential role of RGS5 signaling pathway activation for PC dysfunction. We will use our findings to discover new therapeutic approaches to reverse muscularization and restore lung vascular health.

PI_NAMEs: MELERO-MARTIN, JUAN M;YUAN, KE  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Animal Model;Apoptosis;arteriole;Blood capillaries;Blood Vessels;capillary bed;Cell Communication;Cell Physiology;Cells;Cellular Assay;Cessation of life;Characteristics;Clinical;Coculture Techniques;CRISPR/Cas technology;Culture Techniques;Data;Development;Diameter;Disease;Disease Progression;Distal;Endothelial Cells;Exhibits;Extravasation;Fibroblasts;Foundations;Functional disorder;Genetic Engineering;GTP-Binding Protein Regulators;Health;Homeostasis;Human;Hypoxia;hypoxia-induced pulmonary hypertension;Impairment;implantation;induced pluripotent stem cell;insight;Knock-out;Knowledge;Lesion;Life;Lung;lung pressure;Mediating;meter;migration;Modeling;Molecular;Motility;mouse model;Mus;Muscle;novel;novel therapeutic intervention;novel therapeutics;Nude Mice;Organoids;overexpression;Pathologic;Pathway interactions;Patients;Pericytes;Pharmaceutical Preparations;Phenotype;Play;Population;premature;pressure;prevent;primary pulmonary hypertension;Proliferating;pulmonary arterial hypertension;pulmonary artery endothelial cell;Pulmonary Hypertension;pulmonary vascular remodeling;Regulation;Resistance;right ventricular failure;Right Ventricular Hypertrophy;Role;Sampling;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Skin;Smooth Muscle;stem cells;Stroke;Structure of parenchyma of lung;Testing;therapeutic target;Time;Transgenic Animals;Transgenic Mice;Transgenic Organisms;Tube;tumor;Vascular remodeling

PROJECT_TITLE: Pericyte contribution to capillary remodeling in pulmonary arterial hypertension

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Networking and Information Technology R&D (NITRD)

ORG_CITY: BALTIMORE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Vertebral compression fractures, the most common fragility fractures secondary to osteoporosis, are effectively treated with vertebral augmentation, which rapidly reduces pain and restores function. The goal of this project is to advance surgical robotics technology for vertebral augmentation to reduce radiation dose, increase safety, and improve efficacy. This will be accomplished by developing a novel class of tool-mounted robots and a suite of powerful image-based algorithms for automated intra-operative planning, verification, and control, integrated in mixed reality for remote actuation and assurance.

PI_NAMEs: UNBERATH, MATHIAS  (contact)

PROGRAM_OFFICER_NAME: LIU, GUOYING

PROJECT_TERMS: 3-Dimensional;Acute Pain;Adoption;Affect;aging related;Algorithms;arm;automated algorithm;Automation;Back Pain;bone;Bone Cements;bone loss;Cadaver;Cancer Patient;Cannulas;Clinical;Complement;Complex;Complication;Compression Fracture;cost;Dedications;design;Development;Disease;Dose;effective therapy;efficacious treatment;Ensure;Environment;experience;Exposure to;Family;Feedback;flexibility;Fluoroscopy;fragility fracture;functional restoration;Goals;Image;image guided;Image-Guided Surgery;improved;Individual;innovation;instrument;Intervention;Learning;Malignant Neoplasms;mixed reality;multidisciplinary;novel;Occupational;Operative Surgical Procedures;Osteoporosis;Outcome;Outpatients;pain reduction;pain relief;Palliative Care;Patient-Focused Outcomes;Patients;Performance;Positioning Attribute;Procedures;Provider;Psychosocial Factor;Quality of life;Radiation;Radiation Dose Unit;Radiation exposure;Recommendation;Risk;Robot;robot assistance;robotic system;Robotics;Roentgen Rays;Safety;Secondary to;Secure;Series;Site;spine bone structure;System;Systems Integration;Techniques;Technology;Testing;Time;Tissues;tool;Vertebral column;X-Ray Computed Tomography;X-Ray Medical Imaging

PROJECT_TITLE: A Multi-robot System for Semi-automated Image-guided Vertebral Augmentation

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Comparative Effectiveness Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Physical Activity;Prevention;Telehealth

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The use of smart devices and other wearables to deliver personalized, digital interventions to patients in real time to assist with management of chronic diseases has grown significantly in the past few years. We propose to combine ML algorithms and data integration techniques with the standard statistical tools used to assess causal effect moderation to improve tailoring strategies for prevention and treatment of chronic diseases.

PI_NAMEs: DEMPSEY, WALTER  (contact)

PROGRAM_OFFICER_NAME: YUAN, JEAN

PROJECT_TERMS: Accounting;adaptive intervention;Algorithms;analytical method;arm;Behavioral Medicine;Cardiovascular Diseases;cardiovascular disorder prevention;Cellular Phone;Characteristics;Chronic Disease;Collaborations;Complex;Computer software;Data;Data Analytics;data integration;deep learning;design;digital delivery;digital intervention;effective intervention;Effectiveness of Interventions;Equation;Experimental Designs;Frequencies;gradient boosting;Health;Health system;high dimensionality;hypertensive;improved;Individual;interest;Intervention;intervention cost;intervention delivery;Linear Models;Machine Learning;machine learning algorithm;Methods;mHealth;Modeling;novel;Outcome;outcome prediction;Participant;Patients;Physical activity;Population;portability;Prevention strategy;random forest;randomized trial;Recovery Support;Refit;Research Personnel;response;Sample Size;Scientist;sensor;smart device;smart watch;smoking cessation;Societies;Sodium;Source;Specific qualifier value;statistics;substance use;success;Suicide prevention;Techniques;Technology;therapy design;Time;tool;treatment effect;Uncertainty;user-friendly;Validation;wearable device;Work;Writing

PROJECT_TITLE: Leveraging ML algorithms and data integration techniques to improve efficiency of causal moderation analyses of micro-randomized trial data


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Immunotherapy;Rare Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Arf1 is one of the molecular determinants driving oral cancer development and progression. We propose a novel and more effective Arf1-targeted therapy that can simultaneously inhibit tumor survival and promote antitumor immune response. The successful completion of this project will lay a scientific foundation for the design and execution of Arf1 selective inhibitors and offer new opportunities to revitalize targeted treatment for patients with advanced HPV-unrelated oral cancer.

PI_NAMEs: TENG, YONG  (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: ADP-Ribosylation Factor 1;Affect;anti-tumor immune response;anticancer activity;Antineoplastic Agents;antitumor effect;Apoptosis;Automobile Driving;Biological Availability;C57BL/6 Mouse;Cancer Biology;cancer cell;Cancer Patient;cancer regression;cancer therapy;carcinogenesis;CASP1 gene;CD8-Positive T-Lymphocytes;Cell Death;Cell Maturation;Cells;Cessation of life;Cetuximab;Clinical;cytotoxic;cytotoxicity;Decitabine;Dendritic Cells;design;Development;Diagnosis;Epidermal Growth Factor Receptor;Exhibits;Family;Family member;FDA approved;Foundations;Genetic;Goals;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate Phosphohydrolases;Head and Neck Cancer;HPV negative;Human Papillomavirus;Hyperactivity;Immune;Immune checkpoint inhibitor;Immune response;Immunity;immunogenic;Immunooncology;Impairment;improved;Incidence;Inflammasome;inhibitor;Interruption;keratinocyte;malignant mouth neoplasm;Malignant Neoplasms;marenostrin;Mediating;member;Membrane;Molecular;Monoclonal Antibodies;Monomeric GTP-Binding Proteins;Mouth Neoplasms;Mus;novel;novel therapeutics;Oncogenic;Oral;Outcome;Patients;PD-1/PD-L1;PD-L1 blockade;Pilot Projects;Play;pre-clinical;prevent;Process;Production;Prognosis;programmed cell death protein 1;protein protein interaction;Proteins;rational design;Reactive Oxygen Species;response;Role;Scheme;Signal Transduction;Source;success;Survival Rate;T-Cell Activation;T-Cell Depletion;T-Lymphocyte;targeted agent;targeted treatment;Techniques;Testing;Toxic effect;trafficking;Treatment Efficacy;tumor;tumor eradication;Tumor Immunity;tumor immunology;tumor progression;tumor-immune system interactions;Tumor-infiltrating immune cells

PROJECT_TITLE: Targeted Arf1 inhibition to enhance immune response in oral cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCTC-S (01)]


ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Parasitic intestinal worms and gut bacteria have co-evolved with humans and other mammals. A better understanding of how worms and bacteria interact in the gut may lead to new ways of controlling worm infections and reducing disease.

PI_NAMEs: CADWELL, KEN HASHIGIWA (contact);HUBBARD, E. JANE ALBERT

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Adult;Affect;Anabolism;Anemia;Arginine;Back;Bacteria;bacterial community;Bacterial Proteins;Binding;Biological Assay;Caenorhabditis elegans;Chitinase;Colon;Communities;Deposition;Development;Diet;Disease;Distant;Drug resistance;egg;Environment;Escherichia coli;Feces;Feeds;Frequencies;Gastrointestinal tract structure;Gnotobiotic;gut bacteria;gut microbiota;hatching;Helminths;Hemorrhagic colitis;host colonization;Human;human microbiota;human pathogen;Impaired cognition;improved;In Vitro;in vivo;Individual Differences;Infection;Inflammatory Response;Ingestion;innovation;Intestines;Knock-out;Knowledge;Large Intestine;Larva;Libraries;Life Cycle Stages;Link;Malnutrition;Mammals;Mediating;Microbe;microbial;microbial based therapy;microbiota composition;Modeling;mouse model;Mus;mutant;Nematoda;novel;Outcome;Parasites;Parasitic nematode;Pathway interactions;Persons;Pharmaceutical Preparations;Polyamines;Production;Reproduction;reproductive;reproductive fitness;Role;Severity of illness;Signal Induction;Site;Symptoms;System;Techniques;Testing;therapeutic target;Time;Trichocephalus trichiura;Trichuris;Trichuris trichiura infection

PROJECT_TITLE: Interactions between Trichuris and the gut microbiota

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IMII-U (01)]


NIH_SPENDING_CATS: Digestive Diseases

ORG_CITY: CHICAGO

ORG_DEPT: PATHOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Narrative Soluble epoxide hydrolase plays a critical role in gastrointestinal (GI) mucosa barrier homeostasis and is a crucial enzyme involved in the inactivation of anti-inflammatory epoxy oxylipins and NSAIDs-induced GI ulcer formation. Targeting soluble epoxide hydrolase represents a unique preventive/therapeutic approach against GI mucosa barrier damage and to augment NSAIDs's anti-inflammatory activities while minimizing its adverse effects.

PI_NAMEs: YANG, GUANG-YU  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: 3xTg-AD mouse;Adverse effects;Aflatoxin B1;Agonist;Anti-Inflammatory Agents;Apoptosis;Aspirin;Binding Proteins;Biology;Cell Adhesion Molecules;Cell Lineage;Cytochrome P450;cytokine;cytokine release syndrome;Dinoprostone;Drug Kinetics;Eicosanoids;Endoplasmic Reticulum;endoplasmic reticulum stress;Endothelial Cells;Endothelium;Enterocytes;Enzymes;Epithelial Cells;epithelial injury;Epithelium;epithelium regeneration;Epoxide hydrolase;Fatty Acids;Fibrosis;gastrointestinal;Genetically Engineered Mouse;Glycols;Goblet Cells;healing;Homeostasis;In Vitro;in vivo;Inflammation;Inflammatory;inhibitor;Injury;intestinal barrier;intestinal crypt;intestinal epithelium;intestinal injury;Intestinal Mucosa;Intestines;Knock-out;Knockout Mice;Leukotriene B4;Lipids;Macrophage;Mediating;microorganism toxin;migration;Mitochondria;Modeling;Molecular;Molecular Biology;mouse model;Mucinous;Mucins;Mucous Membrane;Mus;Natural regeneration;NF-kappa B;novel;Organoids;overexpression;Pathway interactions;Pharmaceutical Preparations;Phenotype;Play;Polyunsaturated Fatty Acids;Positioning Attribute;PPAR gamma;preservation;Preventive;Process;Production;receptor;receptor binding;response;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;stem cell proliferation;Stress;Testing;Therapeutic;thyroid hormone receptor associated protein 220;Tight Junctions;TNF gene;Toxic effect;Toxin;transcriptome;Transgenic Mice;Ulcer;Vascular Endothelial Cell;villin

PROJECT_TITLE: Role of epoxy fatty acids - soluble epoxide hydrolase axis in intestinal mucosal barrier defense

STUDY_SECTION: DBDT

STUDY_SECTION_NAME: Drug and Biologic Disposition and Toxicity Study Section[DBDT]


NIH_SPENDING_CATS: Diabetes;Obesity;Prevention

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE Insulin resistance is a major factor in the pathology of obesity-associated type 2 diabetes mellitus. We have identified two enzymes that together control the functional state of the insulin receptor through a novel negative feedback loop, and demonstrate that this receptor inhibition is increased in obesity to drive insulin resistance. Understanding this novel mechanism regulating insulin sensitivity may allow identification of new drug targets to treat insulin resistance in metabolic syndrome and type 2 diabetes mellitus.

PI_NAMEs: STAMLER, JONATHAN S. (contact);ZHOU, HUALIN

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Acute;Adipose tissue;Age;age related;Aging;American;Arginine;Blood Glucose;Body mass index;Chemicals;Chronic;clinically significant;Coenzyme A;cofactor;Correlation Studies;Diabetes Mellitus;Disease;Enzymes;Feedback;Female;Glucocorticoids;Goals;Health;Human;human data;Hypoglycemia;Incidence;inhibitor;insight;Insulin;Insulin Receptor;insulin receptor substrate 1 protein;Insulin Resistance;insulin sensitivity;insulin signaling;Knockout Mice;Link;Liver;male;Mammals;Mediating;Mediator;Metabolic;Metabolic Diseases;Metabolic syndrome;Modeling;Modification;Molecular;Molecular Profiling;Muscle;mutant;NADP;new therapeutic target;Nitric Oxide;Non-Insulin-Dependent Diabetes Mellitus;NOS2A gene;NOS3 gene;novel;novel therapeutics;Obesity;overexpression;Oxidoreductase;Pathologic;Pathology;Patients;Pharmaceutical Preparations;pharmacologic;Physiological;Physiology;Population;Prediabetes syndrome;prevent;Production;Protein S;Proteins;Receptor Inhibition;receptor sensitivity;Refractory;Role;S-Nitrosothiols;Signal Transduction;Site;Skeletal Muscle;skeletal tissue;Sulfhydryl Compounds;Testing;Therapeutic;therapeutic target;Tissues;Work

PROJECT_TITLE: A Novel Nitrosylase Prevents Hypoglycemia and Mediates Insulin Resistance

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: PROJECT NARRATIVE Critical to controlling drug-resistant tuberculosis (DR-TB) are early detection of the disease and accurate detection of drug resistance; however, traditional drug susceptibility tests (DST) are either too slow or too expensive for use as first line diagnostics. Here, we propose to utilize novel probes based on the sugar trehalose to develop a phenotypic, drug-agnostic, rapid, and low-complexity DST designed for resource limited settings. As most countries in the WHO list of high burden countries are developing countries with limited resources, successful development of the proposed DST will significantly impact DR-TB control worldwide.

PI_NAMEs: KAMARIZA, MIREILLE  (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Address;Antitubercular Agents;Bacteria;Benchmarking;Biological Markers;Caring;Cause of Death;Clinical;clinical application;Clinical Research;Combined Modality Therapy;companion diagnostics;cost;cost effective;cost effectiveness;Country;COVID-19;COVID-19 pandemic;design;detection limit;detection method;Developing Countries;Development;Diagnosis;Diagnostic;Diagnostic Procedure;Disease;Drug Controls;Drug resistance;Drug resistance in tuberculosis;Drug resistant Mycobacteria Tuberculosis;drug testing;Drug usage;Early Diagnosis;Evaluation;Extreme drug resistant tuberculosis;Family;Flow Cytometry;Fluorescence;Friends;Future;Genotype;improved;In Vitro;Individual;Infection;Infectious Agent;Knowledge;Label;Measurement;Measures;Metabolic;Methods;Microscopy;Minimum Inhibitory Concentration measurement;Molecular;Multidrug-Resistant Tuberculosis;Mycobacterium tuberculosis;Mycobacterium tuberculosis H37Rv;Newly Diagnosed;next generation;Noise;novel;Nucleic Acid Amplification Tests;Oral mucous membrane structure;Outcome;Patients;Performance;performance tests;Persons;Pharmaceutical Preparations;Phase;Phenotype;point of care;pre-pandemic;Predisposition;programs;Protocols documentation;Reader;Recommendation;Regimen;Reporting;Reproducibility;research clinical testing;Resistance;resistance mutation;Resistance to infection;resistant strain;Resource-limited setting;Resources;Rifampicin resistance;sample collection;Signal Transduction;South Africa;Specificity;Specimen;Sputum;success;sugar;System;Testing;Time;Trehalose;Tuberculosis;Tuberculosis diagnosis;tuberculosis diagnostics;tuberculosis drugs

PROJECT_TITLE: A Rapid Phenotypic Drug Susceptibility Testing System for Tuberculosis

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Congenital Structural Anomalies;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Primary Immunodeficiencies;Psychosis;Rare Diseases;Serious Mental Illness;Social Determinants of Health

PHR: PROJECT NARRATIVE Neuropsychiatric manifestations are common in 22q11.2 deletion syndrome (22qDS), affecting brain development and functioning with marked heterogeneity. We propose to examine developmental trajectories in a cohort of adolescents and young adults and their parents, integrating prospective dimensional and categorical phenotyping of psychopathology, neurobehavioral, environmental exposures, and medical burden. This work will identify convergent risk mechanisms for developmental neuropsychiatric disorders that have relevance to the broader population.

PI_NAMEs: MCDONALD-MCGINN, DONNA MARIE (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: 22q;22q11.2;Acceleration;Address;Adolescence;Adolescent and Young Adult;Affect;Age;Algorithms;Anxiety;Architecture;Attention deficit hyperactivity disorder;Authorization documentation;autism spectrum disorder;Behavior;Behavioral;Brain;brain behavior;case control;Cell Line;Clinical;Clinical Data;Cognitive deficits;cohort;Collaborations;comorbidity;computerized;critical period;Data;data sharing;Development;Developmental Course;Developmental Delay Disorders;DiGeorge Syndrome;Dimensions;Disease;DNA;Early identification;Electronic Health Record;emerging adult;emerging adulthood;Environmental Exposure;Environmental Impact;Environmental Risk Factor;Evaluation;executive function;externalizing behavior;Family;Female;functional outcomes;General Population;Genes;Genetic;Genetic Risk;genetic variant;Genetic Variation;Genome;genome resource;Genomics;Goals;Grain;Heterogeneity;high risk;Home;Individual;insight;Institution;Intellectual functioning disability;intergenerational;International;Investigation;Knowledge;Laboratories;Language;Language Development;Lead;life span;Link;Literature;longitudinal design;male;Measures;Medical;Mental Health;Methods;model building;multimodality;National Institute of Mental Health;Nature;Neighborhoods;neurobehavioral;Neurocognition;Neurocognitive;Neurocognitive Deficit;neuropsychiatric disorder;neuropsychiatry;novel;offspring;Outcome;Parents;Pediatric Hospitals;Performance;Persons;Pharmaceutical Preparations;phenome;phenomics;Phenotype;phenotypic data;Philadelphia;Play;polygenic risk score;Population;Positioning Attribute;precision medicine;prenatal;proband;prospective;Psychiatry;Psychopathology;Psychoses;psychotic symptoms;Public Domains;Recontacts;Recording of previous events;recruit;Research;research clinical testing;resilience;resilience factor;Resources;response;Risk;Risk Factors;risk prediction model;Role;Sampling;severe mental illness;Short-Term Memory;Stress;Syndrome;Testing;Variant;Work;young adult;Youth

PROJECT_TITLE: 2/2 - Neurodevelopmental Trajectories in 22q11.2 Deletion Syndrome in Adolescence and Young Adulthood

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EPH-D (65)]


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Narrative Many eukaryotic cells undergo rapid changes in shape or size, which changes the cell surface area. To accommodate these changes, cells fuse the cell surface to internal membrane structures to allow for the rapid exchange of membranes. This mechanism seems to play an important role not only to avoid cell rupture but also in the function of many human cells, including blood platelets and neuronal development.

PI_NAMEs: BABST, MARKUS  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Acute;acute stress;Address;Affect;anti-fungal agents;Area;biological adaptation to stress;Blood Platelets;Bypass;Cell Differentiation process;Cell fusion;Cell membrane;Cell Shape;Cell surface;Cells;Cellular Stress;Charge;Chemicals;Complex;Cytokinesis;Cytoskeleton;Data;Drops;Elasticity;Endocytosis;Environment;environmental change;Ergosterol;Eukaryotic Cell;Event;Excision;experience;Goals;Growth;Homologous Protein;Human;insight;Ion Channel;Kinetics;lipid transport;Lipids;Mediating;Membrane;membrane flux;Membrane Fusion;Metabolic;Metabolism;Microfluidics;migration;mitochondrial metabolism;Modeling;Morphology;neuron development;Nutrient;Organism;Osmolar Concentration;Osmosis;Osmotic Shocks;Pathway interactions;Phase;Phosphotransferases;Physically Challenged;Physiological;Plasma;Play;Proteins;Recovery;recruit;Regulation;response;Role;Rupture;Saccharomyces cerevisiae;segregation;sensor;Shapes;Shock;Signal Transduction;Site;Sterols;Stress;Structure;Surface;System;Tensile Strength;Testing;trafficking;Transmembrane Transport;Yeasts

PROJECT_TITLE: Plasma membrane stress response

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


NIH_SPENDING_CATS: Atherosclerosis;Bioengineering;Cardiovascular;Clinical Research;Emergency Care;Health Services;Heart Disease;Heart Disease - Coronary Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_DEPT: EMERGENCY MEDICINE

PHR: PROJECT NARRATIVE Women and those of non-white races are over-represented among patients who experience delays in care for the deadliest form of a heart attack, ST-elevation myocardial infarction (STEMI). Each minute of delay increases the risk of death, so we will develop diversity-inclusive artificial intelligence (AI) to support early diagnosis of STEMI. This AI will calculate the risk for a heart attack, with attention to improving the identification of women and non-white patients.

PI_NAMEs: YIADOM, MAAME YAA A.B. (contact)

PROGRAM_OFFICER_NAME: SHIROMA, ERIC JITSUO

PROJECT_TERMS: Accident and Emergency department;acute coronary syndrome;Age;Artificial Intelligence;artificial intelligence model;associated symptom;Attention;Biometry;Cardiology;Caring;Caucasians;Characteristics;Chest Pain;Clinical;Clinical Data;clinical decision support;Clinical Informatics;Data;Data Set;demographics;Diagnosis;Diagnostic;disparity reduction;Disproportionately impacts women;diversity and inclusion;Early Diagnosis;Early identification;Effectiveness;Electrocardiogram;Emergency Care;Emergency Department patient;Emergency department screening;Emergency department visit;Emergency Medicine;Ensure;Equity;Ethnic Origin;Evaluation;experience;Frequencies;Goals;improved;In Vitro;in vivo;innovation;Intake;Intervention;Life;Logistic Regressions;Machine Learning;machine learning model;Manuals;men;Methods;Modeling;mortality;mortality risk;multidisciplinary;Myocardial Infarction;Outcome;outcome disparities;Pathway interactions;Patients;Performance;personalized diagnostics;Physicians;Population;predictive modeling;prevent;programs;Prospective, cohort study;prototype;Race;Recommendation;Reporting;Risk;risk prediction model;Safety;screening;sex;simulation;sociodemographics;Specificity;Structure;Subgroup;Symptoms;Testing;Time;Training;training data;Translating;Translational Research;Translations;Woman;Work

PROJECT_TITLE: Using Predictive Modeling for Acute Coronary Syndrome Screening to Improve Timely Diagnosis and Mortality for STEMI

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Comparative Effectiveness Research;Diabetes;Health Services;Nutrition;Obesity;Prevention

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

PHR: PROJECT NARRATIVE Antiobesity medications can help patients increase their weight loss and achieve better health. Unfortunately, there is very little research comparing the safety and impact of the different available antiobesity medicines, and most eligible patients with obesity are not prescribed one. To make prescribing decisions easier for patients and doctors, we will use insurance claims data from across the United States to study how different antiobesity medications impact health and health care use.

PI_NAMEs: LEWIS, KRISTINA H;TOH, DARREN  (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Address;Adult;Affect;Age;Agonist;American;Arrhythmia;bariatric surgery;Bariatrics;Behavior Therapy;Body mass index;Body Weight;Body Weight decreased;Bupropion;cardiometabolism;Cardiovascular system;Characteristics;Chronic Disease;Clinical;clinical practice;Clinical Research;Clinical Services;Clinical Trials;clinically significant;cohort;comorbidity;comparative;comparative effectiveness;Comparative Effectiveness Research;comparative effectiveness study;Complication;cost;Data;Data Set;design;Development;Diabetes Mellitus;Drug Prescriptions;Dyslipidemias;Economics;Effectiveness;Eligibility Determination;Emergency department visit;Emergency Situation;Epidemiology;Event;FDA approved;follow-up;glucagon-like peptide 1;Guidelines;Head;Health;Health Care Costs;health care service utilization;Health Insurance;health service use;Health Services;Healthcare;Heart failure;Hospitalization;Hypertension;hypertensive;improved;Incidence;Individual;individualized medicine;insurance claims;Intention;Intervention;Lead;Length of Stay;Life Style;lifestyle intervention;liraglutide;Measures;Medical Care Costs;Medicine;Morbid Obesity;Myocardial Infarction;Naltrexone;New Agents;Non-Insulin-Dependent Diabetes Mellitus;obese patients;Obesity;Obesity Epidemic;obesity treatment;Outcome;Outpatients;Patients;Pharmaceutical Preparations;Pharmacotherapy;pharmacy benefit;Pharmacy facility;Phentermine;Physicians;Policies;Procedures;programs;Provider;Qualifying;Recommendation;Research;revascularization;Risk;Safety;sex;Stroke;Techniques;topiramate;treatment choice;United States;Update;Visit;Weight

PROJECT_TITLE: Comparative effectiveness of anti-obesity medications for cardiometabolic health outcomes and health services use

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


NIH_SPENDING_CATS: Atherosclerosis;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Heart Disease;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Statins reduce the risk of major adverse cardiovascular events and mortality. However, providers fail to prescribe statin therapy for about half of patients meeting guideline criteria for initiation. The overall objective of this proposal is to develop and optimize a clinical decision support system, including several electronic health record nudges, to increase guideline-concordant statin prescribing.

PI_NAMEs: RICHARDSON, SAFIYA  (contact)

PROGRAM_OFFICER_NAME: KHAN, SHAHNAZ

PROJECT_TERMS: Adoption;Atherosclerosis;behavior influence;Behavior Therapy;behavioral economics;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Caring;Clinical;Clinical Decision Support Systems;Clinical Sciences;Cognitive;cognitive load;comorbidity;Consent;Data;Decision Making;demographics;design;Development;Dose;Drug Prescriptions;Electronic Health Record;Elements;emotional factor;Engineering;Enrollment;Ensure;Event;evidence base;Goals;Guidelines;Health;improved;Individual;innovation;insight;Intervention;Laboratories;Lead;Measures;Medical History;meetings;Methods;Modeling;mortality;multiphase optimization strategy;novel strategies;Organ Donations;Patient risk;Patients;Pattern;peer;Positive Reinforcements;Process;Provider;provider adoption;provider-level barriers;psychologic;Public Health Informatics;randomized trial;Resources;Risk;Risk Assessment;Risk Management;Risk Reduction;social;Suggestion;Systems Development;Testing;Time;Unconscious State;United States National Aeronautics and Space Administration;usability;user centered design;visual tracking;wasting;Work

PROJECT_TITLE: EHR Nudges: Optimizing a Clinical Decision Support System for Evidence-Based Statin Medication Prescribing to Reduce the Risk of Cardiovascular Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-W (02)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Alzheimer’s disease, characterized by a progressive decline in cognitive function, is the most common form of dementia. Large-scale genomics studies have recently converged on VGF as a critical driver (regulator) in the signaling networks that underlie Alzheimer’s disease pathogenesis and progression in human patients, and data from our labs further demonstrate that VGF overexpression or intracerebroventricular administration of VGF-derived peptides to the 5xFAD mouse model reduces amyloid plaque load, microgliosis and astrogliosis, in the brain. The proposed studies will optimize intranasal nose-to-brain VGF peptide delivery, will determine whether these VGF peptides engage targets in the brain, and will investigate efficacy of intranasal peptides to rescue neuropathology and memory impairment in mouse models of neurodegeneration, providing a firm foundation for future translation of VGF therapeutics to human subjects with Alzheimer’s disease.

PI_NAMEs: EHRLICH, MICHELLE E;SALTON, STEPHEN R (contact)

PROGRAM_OFFICER_NAME: RUNKO, ALEXANDER PETER

PROJECT_TERMS: Acceleration;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer’s disease biomarker;Amino Acids;Amyloid;Amyloid deposition;Amyloidosis;animal imaging;anti-depressive agents;Astrocytes;astrogliosis;awake;Behavior;Behavioral;Biochemical;Biological Availability;Biological Markers;Biotin;Biotinylation;Blood - brain barrier anatomy;Brain;Brain region;Brain-Derived Neurotrophic Factor;Bypass;C-terminal;C3AR1 gene;candidate marker;Cerebral cortex;Chemistry;chemokine;Chronic;Circulation;cognitive function;Collaborations;Complement;CREB1 gene;cyanine dye 5;Data;Dementia;density;Development;Disease;Disease Progression;dosage;Dose;drug discovery;Drug Kinetics;Early Onset Alzheimer Disease;efficacy trial;entorhinal cortex;Enzyme-Linked Immunosorbent Assay;Evaluation;exosome;experimental study;FOS gene;Foundations;Frequencies;frontal lobe;Future;G-Protein-Coupled Receptors;Gene Expression;Genes;genetic approach;Genomic approach;Genomics;Gliosis;Health;Hippocampus;Histologic;Hormones;Human;human subject;Image;Impaired cognition;improved;in vivo imaging;in vivo imaging system;Infusion procedures;Intervention;Intranasal Administration;Label;Late Onset Alzheimer Disease;Length;Lesion;Longevity;Maps;Mass Spectrum Analysis;Measures;Medicine;Memory;Memory impairment;Memory Loss;Mental Depression;Messenger RNA;Methods;Microglia;Modeling;Modification;mouse model;Mus;N-terminal;Names;Nerve Degeneration;neural;Neurodegenerative Disorders;Neurofibrillary Tangles;neurogenesis;neuroinflammation;neuron loss;Neuronal Plasticity;Neurons;neuropathology;Neuropeptides;neurotrophic factor;Nose;Oral;Organ;overexpression;Pathogenesis;Pathologic;Patients;peptide drug;Peptides;Peripheral;Phenotype;Pre-Clinical Model;preclinical study;Process;programs;Proteins;Publishing;Radioimmunoassay;receptor;Schedule;Senile Plaques;side effect;Signal Pathway;Signal Transduction;Spinal;Streptavidin;Support System;Synapses;systemic toxicity;Systems Biology;tau aggregation;tau Proteins;tau-1;Tauopathies;Temporal Lobe;Testing;Therapeutic;Therapeutic Effect;Time;Tissues;Toxic effect;transcriptome sequencing;Translations;treatment effect;Treatment Efficacy;Treatment-related toxicity;uptake;Visualization;Western Blotting

PROJECT_TITLE: Intranasal delivery of VGF-derived peptides in a preclinical model of Alzheimer's disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dietary Supplements;Digestive Diseases;Microbiome;Nutrition;Obesity;Prevention

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE Excess dietary fructose consumption is common and elicits an array of metabolic consequences, including obesity, inflammation, fatty liver, insulin resistance and type 2 diabetes. The human gut microbiome has also been associated with these conditions and may be modified by excess fructose consumption, yet the role of the microbiome as a mediating factor between fructose and metabolic health in humans has not been examined. In this proposal we will evaluate causal relationships between the gut microbiome and metabolic risk using a controlled human dietary trial followed by fecal transplant microbiome studies in germ-free mice.

PI_NAMEs: WALKER, RYAN  (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Address;Adult;American;Animals;arm;Bacteria;blood glucose regulation;Calories;Carbohydrates;Carbon;Characteristics;Child;Clinical;Clinical Trials;Colon;Communities;Complex;Computing Methodologies;Consumption;Cross-Over Trials;Cross-Sectional Studies;cytokine;Data;design;diabetes risk;Diet;dietary;dietary excess;Dietary Intervention;Dimensions;Disease;disorder risk;elastography;Endotoxemia;Etiology;Fatty acid glycerol esters;Fatty Liver;fecal transplantation;Feces;Fructose;Future;Gases;Germ-Free;Glucose;Goals;gut health;gut microbiome;gut microbiota;Health;Human;human disease;human microbiota;improved;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;Insulin Resistance;Intervention;Intervention Studies;Intestinal permeability;Isotopes;Knowledge;Label;Large Intestine;Link;Liver;Magnetic Resonance Imaging;Malabsorption Syndromes;Mass Spectrum Analysis;Measures;Mediating;Mediator;Metabolic;Metabolic Diseases;Metabolism;metabolomics;metagenomic sequencing;Microbe;microbial;microbiome;microbiome alteration;microbiome research;microbiota;Modeling;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Outcome;oxidation;Participant;Population;Prevalence;Prevention;Process;Production;Randomized;Research;Research Design;Risk;Rodent Model;Role;Sampling;Serum Markers;Small Intestines;Statistical Methods;stool sample;Structure;sugar;sweetened beverage;Testing;Transplantation;Vulnerable Populations

PROJECT_TITLE: The effects of a high fructose diet on the gut microbiome and metabolic health: A controlled clinical intervention study

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Biotechnology;Cancer;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: RICHMOND

ORG_DEPT: DENTISTRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: Project Narrative Despite being rare, MYCN-amplified neuroblastoma (NB) accounts for ~7% of all pediatric cancer related deaths and is driven by the oncogenic transcription factor MYCN and a MYCN-directed adrenergic (ADRN) core regulatory complex (CRC) of self-regulating and inter-regulated transcription factors that drive the MYCN- amplified NB transcriptome. In this proposal, we demonstrate MYCN drives a SUMOylation program in NB and MYCN confers synthetic lethality to the in-clinic SUMOylation inhibitor, TAK-981. TAK-981 disrupts the ADRN CRC, only in the presence of MYCN, to induce ADRN CRC collapse and cell death, and thus represents an exciting new therapy for this recalcitrant pediatric tumor.

PI_NAMEs: FABER, ANTHONY CHARLES (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: addiction;Adrenergic Agents;Age;Antibodies;Applications Grants;ASCL1 gene;Categories;Cell Death;Cessation of life;Child;Childhood;Clinic;Clinical;Clinical Trials;clinically actionable;combat;Combined Modality Therapy;Complex;Data;Disease;disorder risk;Down-Regulation;Drug Targeting;effective therapy;efficacy testing;Genetic Transcription;Genomics;Goals;Grant;high risk;Hypersensitivity;Immunotherapy;improved outcome;In Vitro;in vivo;inhibitor;Maintenance Therapy;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;Modeling;mouse model;Mutation;MYCN gene;Natural Killer Cells;Neuroblastoma;neuroblastoma cell;NK Cell Activation;novel;novel therapeutics;Oncogenic;participant enrollment;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;Pediatric Neoplasm;Pharmacologic Substance;Phosphotransferases;pre-clinical;preclinical study;programs;Proteomics;Relapse;research clinical testing;Research Design;Research Personnel;Retinoids;Safety;Series;Sumoylation Pathway;Surface;Testing;Therapeutic;Time;Toxic effect;transcription factor;transcriptome;Tretinoin;tumor;weapons

PROJECT_TITLE: MYCN drives a druggable SUMOylation program in neuroblastoma

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences

PHR: Project Narrative  This multi-disciplinary proposal leverages molecular biology, deep-network learning, and in vivo microscopy to develop a suite of first-in-class tools to directly observe synaptic plasticity in living animals using minimally invasive methods. We seek to explain how dynamic modulation of specific synaptic circuits encodes learning and memory. By studying the fundamental mechanisms of memory encoding, we endeavor to gain insights into treating neurological disorders involving aberrant memory function, such as Alzheimer’s disease and PTSD.

PI_NAMEs: HUGANIR, RICHARD L (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Address;Affective;Algorithms;Alzheimer's Disease;AMPA Receptors;Animals;Aplysia;Architecture;Behavior;Brain;brain cell;Brain region;brain volume;Cell surface;cell type;Cephalic;Chemicals;Cognition;cognitive function;Communication;Complex;complex biological systems;computational pipelines;Computer Vision Systems;Coupled;Data Set;deep learning;Detection;Dyes;Excitatory Synapse;experience;Extinction;extracellular;Fluorescence;Fright;genetic analysis;Glutamate Receptor;Goals;high dimensionality;Human;Image;in vivo;in vivo imaging;in vivo two-photon imaging;Individual;insight;interdisciplinary approach;Investigation;Knowledge;Label;Learning;learning network;long term memory;Manuals;Maps;Measures;Memory;memory encoding;Memory impairment;memory process;Methodology;Methods;Microscopy;minimally invasive;Molecular;Molecular Biology;multidisciplinary;Mus;Nature;Nervous System Disorder;neural;neural circuit;Neurons;Neurosciences;novel;Organism;Pathway interactions;Pattern;PHluorin;Physiological;Post-Traumatic Stress Disorders;postsynaptic;presynaptic;Prevalence;Process;Proteins;Proxy;receptor;Regulation;Reporting;Resolution;restoration;skills;Speed;submicron;Synapses;synaptic function;Synaptic plasticity;Techniques;Time;Tissues;tool;Transgenic Mice;Transgenic Organisms;two photon microscopy;Variant;Viral;Visual;Visualization

PROJECT_TITLE: Exploring synaptic encoding of circuit-specific memory in behaving mice

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 LMDN-J (90)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Diabetes;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Liver Disease;Obesity;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Engagement in evidenced-based diabetes prevention programs has historically been low, particularly in the Latino population, who are disproportionally affected by type 2 diabetes. Identifying both clinical and social determinants of health factors that increase diabetes risk and act as barriers for participation in prevention programs is crucial to improve equitable access to diabetes prevention programs. The proposed research aims to use clinical and social determinants of health data readily available in the electronic health record to develop and validate a diabetes prediction model specific to the needs of Latino patients, and engage with patients, clinicians and health care systems to increase enrollment and engagement in diabetes prevention programs.

PI_NAMEs: RODRIGUEZ, LUIS A (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, JEAN M

PROJECT_TERMS: Address;Adoption;Adult;Affect;Alcohol consumption;American;American Heart Association;Biological;California;career development;Clinical;clinical practice;cohort;Communities;Data;design;Diabetes Mellitus;Diabetes prevention;diabetes prevention program;diabetes risk;Disease;disorder risk;Disparity;Doctor of Philosophy;Education;electronic health data;Electronic Health Record;Enrollment;Ensure;Epidemiologist;Epidemiology;Equity;ethnic disparity;Etiology;evidence base;Fatty Liver;Foundations;Funding;Future;Goals;health data;health equity;health inequalities;Health Priorities;Health Services;Healthcare;Healthcare Systems;High Prevalence;high risk;high risk population;Hispanic Community Health Study/Study of Latinos;Housing;implementation science;improved;Incidence;Inequity;innovation;Integrated Health Care Systems;Intervention;Latin America;Latino;Latino Population;Link;Liver diseases;low socioeconomic status;Machine Learning;member;Mentored Research Scientist Development Award;Mentors;Methodology;Mexican Americans;model development;Modeling;Neighborhoods;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;Outcome;outreach;Patients;Persons;Phenotype;Population;Poverty;Prediabetes syndrome;Predictive Factor;predictive modeling;predictive tools;Prevention program;Prevention Research;preventive intervention;professor;racial disparity;Research;Research Personnel;Risk;Risk Factors;risk prediction model;Role;Science;Scientist;Site;skill acquisition;skills;social determinants;social health determinants;Social outcome;social vulnerability;Subgroup;support tools;Testing;tool;Training;Training Programs;Translational Research;Translations;Underinsured;Unemployment;Uninsured;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Evaluating biologic and social determinants of health to improve diabetes prevention and address health inequities in Latino patients.

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The goal of our project is to develop a comprehensive understanding of unique structural features that form the internal skeleton of apicomplexan parasites that cause serious human diseases. The insights gained from this project may inform future efforts to develop improved treatments for parasitic diseases.

PI_NAMEs: SIBLEY, L. DAVID;ZHANG, RUI  (contact)

PROJECT_TERMS: Adopted;Apical;Apicomplexa;base;Biological Models;Cell Fractionation;Comparative Study;Complex;Connecting Stalk;Core Protein;Cryoelectron Microscopy;Cryptosporidium;Cytoskeleton;Data Analyses;Data Collection;Fiber;filamin;Future;Goals;Histone-Lysine N-Methyltransferase;human disease;improved;insight;Knowledge;Link;Maps;Mass Spectrum Analysis;Microtubule-Associated Proteins;Microtubules;Modeling;Motor;Myelin P2 Protein;Organelles;Orthologous Gene;Parasites;Parasitic Diseases;particle;Plasmodium;Positioning Attribute;Process;protein function;Protein Secretion;Proteins;Research;Resolution;Role;Skeleton;Structure;Structure-Activity Relationship;Study models;three dimensional structure;Toxoplasma;Toxoplasma gondii;Tubular formation;Tubulin;Work

PROJECT_TITLE: Structure and Function of the Conoid in Toxoplasma

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Clinical Research;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Acute kidney injury (AKI) is a life-threatening clinical syndrome prevalent in hospitalized patients and have multiple etiologies and diverse outcomes, which highlights the need for personalized intervention. Building on our recent success in personalized predictive modeling, this project aims to develop personalized transfer learning methods to better quantify individual risk for developing AKI in the hospital setting. Results from this project has a broader impact on personalized decision support for improving patient outcomes.

PI_NAMEs: LIU, MEI  (contact)

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;Affect;Cardiovascular Diseases;Cessation of life;Characteristics;Chronic Kidney Failure;Clinical;clinical decision support;cohort;Communication;complex data;Critical Illness;Data;Disease;disorder risk;Electronic Health Record;Ensure;Equity;Etiology;General Population;Goals;Great Plains;Heterogeneity;high risk;Hospitalization;Hospitals;improved;Incidence;Individual;interest;Intervention;Knowledge;Learning;learning strategy;Life;Machine Learning;Measures;method development;Methods;model building;Modeling;Myocardial Infarction;Nature;Outcome;Pathogenesis;patient subsets;Patient-Focused Outcomes;Patients;personalized decision;personalized intervention;personalized predictions;predictive modeling;Prevention;Process;Prognosis;Publications;Risk;Risk Assessment;risk prediction;Site;Subgroup;success;Syndrome;Techniques;Training;transfer learning;Validation;Work

PROJECT_TITLE: Personalized Machine Learning for Acute Kidney Injury Prediction and Prognosis


NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Infectious Diseases;Microbiome;Prevention;Urologic Diseases;Women's Health Research

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE Urinary tract infections (UTI) affect millions of US women, and there is an urgent need to develop better ways to prevent and treat this painful and costly disease. This research will identify how a vaginal bacterial species commonly found in urine makes UTI outcomes worse. This should provide important information that can be used to develop new screening and treatment approaches to limit recurrent UTI.

PI_NAMEs: GILBERT, NICOLE MARIE (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Acute;Adherence;Affect;Antibiotic Resistance;Antibiotic Therapy;Apoptosis;Atopobium vaginae;Attenuated;Automobile Driving;Bacteria;Bacterial Vaginosis;Bacteriuria;Bladder;C57BL/6 Mouse;Catheters;Cell Death;Clinical;Coitus;cost;Cost of Illness;Data;Development;Disease;Dose;dysbiosis;Environment;Enzyme-Linked Immunosorbent Assay;Epithelium;Escherichia coli;Exposure to;Future;Gardnerella;Genes;Genetic;Genome;genomic signature;Genomics;Goals;Health;High Risk Woman;Hour;human data;in vivo;Infection;infection risk;Infective cystitis;innovation;insight;Invaded;Knowledge;Lactobacillus;Link;Measures;Methods;microbial;microbiome composition;Modeling;Molecular;mouse model;Mus;Nature;novel strategies;Outcome;Pain;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;permissiveness;pre-clinical;prevent;Prevention;Prevention approach;Prevention strategy;Proliferating;Publishing;Recording of previous events;Recurrence;Reporting;repository;Research;Risk;Risk Factors;Sampling;Scientist;screening;Sex Behavior;sexually active;small molecule;Specific qualifier value;success;Swab;Testing;Time;Tissues;translational potential;urinary;Urinary Catheterization;Urinary tract;Urinary tract infection;Urine;Uropathogen;Uropathogenic E. coli;Urothelial Cell;Urothelium;Vagina;vaginal microbiome;whole genome;Woman;women's outcomes;Work

PROJECT_TITLE: Molecular and genomic basis of the relationship between Gardnerella, bladder exfoliation and E. coli UTI

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-Y (05)]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Infectious Diseases;Neurosciences;Prevention;Sexually Transmitted Infections;Stroke;Women's Health Research

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: PROJECT NARRATIVE This research will identify how reactive oxygen species associated with ischemia/reperfusion injury elicit mitochondrial calcium entry and depolarization of mitochondrial membrane potential resulting in vascular apoptosis, and we will investigate how these mechanisms elicit greater cell death in males as compared to females. Our complimentary expertise in microvascular physiology with neurobehavioral analysis will allow us to understand how deficits in vascular function following ischemia/reperfusion effect neuronal survival and function. These experiments will provide fundamental new knowledge for identifying innovative avenues of therapy after ischemia/reperfusion injuries such as stroke.

PI_NAMEs: NORTON, CHARLES E (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Acute;Address;Affect;Age Months;Apoptosis;Arteries;Attenuated;Behavioral;Blood flow;Blood Vessels;Brain;brain endothelial cell;Brain Ischemia;C57BL/6 Mouse;Calcium;Cause of Death;Cell Death;Cell Death Induction;Cell Survival;cell type;Cells;cellular resilience;cerebral artery;Cerebrovascular Circulation;Cerebrovascular system;Cerebrum;Cessation of life;Clinical;clinical application;Development;disability;effective therapy;Electron Transport;Endothelial Cells;Endothelium;Event;experimental study;Exposure to;Female;Fluorescence;Genetic;Hemorrhage;Hydrogen Peroxide;improved;in vivo;Individual;Induction of Apoptosis;Infarction;injured;innovation;insight;Intervention;Ischemia;Ischemic Stroke;Knowledge;male;Mediating;Membrane Potentials;Middle Cerebral Artery Occlusion;Mitochondria;mitochondrial membrane;Modeling;Molecular;Mus;neurobehavioral;neuronal survival;Neurons;Neuroprotective Agents;new therapeutic target;novel;Outcome;Oxidative Stress;Oxidative Stress Induction;Patients;Perfusion;pharmacologic;Physiology;post stroke;Predisposition;preservation;pressure;Production;Reactive Oxygen Species;receptor;Regulation;Reperfusion Injury;Reperfusion Therapy;Research;Research Project Grants;resilience;Resistance;response;restoration;Role;Safe Sex;Sex Differences;Signal Induction;Signal Transduction;Smooth Muscle Myocytes;Stroke;stroke therapy;Structure of posterior cerebral artery;targeted treatment;Testing;Therapeutic;Tissues;Traumatic Brain Injury;TRP channel;Tube;uptake;Vascular Smooth Muscle;Vasomotor;Women's mortality

PROJECT_TITLE: Female sex protects vascular smooth muscle cells from mitochondrial depolarization to oxidative stress

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Genetic Testing;Genetics;Human Genome;Lung;Orphan Drug;Precision Medicine;Prevention;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Project Narrative: This ancillary study proposal will incorporate computed tomography scanning with quantitative CT analysis using Data-driven texture analysis as an outcome measure into the PRECISIONS trial. It will also assess the additive value of genetic, genomic, and protein markers for disease progression. Validation will be achieved through replication in 2 external cohorts.

PI_NAMEs: NOTH, IMRE  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Acetylcysteine;Age;Anatomy;Ancillary Study;Biological Markers;Blood;CCL18 gene;Cessation of life;Characteristics;Chicago;clinical decision-making;Clinical Trials;cohort;Collection;Cross-Sectional Studies;Data;Detection;Dimensions;Disease;Disease Marker;Disease Progression;drug development;efficacy testing;FDA approved;Fibrosis;follow-up;Foundations;Gender;Genes;Genetic Markers;Genetic Polymorphism;genetic predictors;genetic variant;genome sequencing;genomic biomarker;high dimensionality;idiopathic pulmonary fibrosis;Image;Image Analysis;improved;Length;Lung Transplantation;Measures;Methods;Modeling;molecular marker;Monitor;Morphology;MUC5B gene;novel marker;Outcome Measure;Parents;Participant;Patients;Pattern;Performance;Pharmaceutical Preparations;Pharmacotherapy;Physiological;Physiology;Plasma;Plasma Proteins;Positioning Attribute;precision medicine;Predisposition;Prognostic Marker;prognostic value;prognostication;Progression-Free Survivals;prospective;protein biomarkers;Proteins;Proteomics;Publishing;Pulmonary Fibrosis;pulmonary function;Radiology Specialty;radiomics;recruit;Registries;Regression Analysis;response;risk variant;Role;Scanning;Severities;Severity of illness;survival prediction;telomere;Texture;Therapeutic Trials;Time;TOLLIP gene;transcriptome;transcriptome sequencing;transcriptomics;treatment response;Validation;Variant;Visual;Vital capacity;whole genome;X-Ray Computed Tomography

PROJECT_TITLE: The role of quantitative CT and radiomic biomarkers for precision medicine in pulmonary fibrosis

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Patient Safety;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: Los Angeles

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Primary angle closure glaucoma (PACG), a leading cause of irreversible vision loss worldwide, is more visually damaging but also more preventable than other common types of glaucoma. Gonioscopy, the current clinical standard for detecting patients at risk for PACG, is ineffective and inconvenient for doctors to use, which contributes to poorly defined practice guidelines, delayed disease detection and treatment, and high prevalence of blindness. We propose to establish anterior segment OCT (AS-OCT), a convenient and precise form of ocular imaging, as the new clinical standard to detect and evaluate individuals at risk for PACG and reduce PACG- related vision loss.

PI_NAMEs: XU, BENJAMIN Y. (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Affect;Aging;Anatomy;Anterior;Aqueous Humor;Biometry;Black Populations;Blindness;burden of illness;Caring;Clinical;clinical application;clinical care;clinical risk;clinically significant;Cluster Analysis;cohort;Computer software;Confusion;Custom;Data;density;design;Detection;Diagnosis;Disease;Disease Outcome;Disparity;disparity reduction;Early Intervention;Eye;Glaucoma;Gonioscopy;health care service utilization;Healthcare Systems;High Prevalence;high risk;high risk population;Hispanic Populations;Image;Image Analysis;Impairment;Individual;Iris;Knowledge;Lighting;Manuals;Measurement;Methodology;Methods;multi-racial;Not Hispanic or Latino;novel;ocular imaging;Participant;Pathogenesis;Pathologic;patient stratification;Patients;Persons;Physiologic Intraocular Pressure;Play;Population;Practice Guidelines;predictive modeling;Prevalence;prevent;Primary Angle Closure Glaucoma;Primary Open Angle Glaucoma;Prophylactic treatment;prospective;racial population;Reproducibility;Research;research clinical testing;Resources;Risk;Risk Factors;risk stratification;Role;Statistical Methods;Statistical Models;System;Time;tool;Training;treatment response;United States;Visual

PROJECT_TITLE: Clinical Evaluation and Risk Stratification of Angle Closure Disease Using Quantitative OCT

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]