ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: MINNEAPOLIS

ORG_NAME: MINNEAPOLIS VA  MEDICAL CENTER

ORG_STATE: MN

PHR: In previous years the total cost of care for Veterans with psychoses has consumed 16% of the Veterans Health Administration (VHA) Veterans Equitable Resource Allocation (VERA) funds. The current investigation is intended to reveal the importance of brain waves – or oscillations - to abnormal visual perceptual experiences and symptoms of psychosis such as hallucinations and illusions. The value of the work is that oscillatory abnormalities can serve as targets for brain interventions that reduce perceptual dysfunction and psychotic symptomatology. Through state-of-the-art analysis of brain electrical activity in people with schizophrenia, this study will test whether the speed of a dominant brain oscillation (i.e., the alpha rhythm) accounts for difficulties in adapting to visual input and accurately seeing objects in one’s environment. The work includes a manipulation of the rhythm to determine if perception can be improved. Alpha manipulation will be personalized and inform neuromodulatory treatment focused on the speed of a Veteran’s alpha rhythm.

PI_NAMEs: SPONHEIM, SCOTT R (contact)

PROJECT_TERMS: Alpha Rhythm;Award;behavior measurement;Binocular rivalry;Brain;brain electrical activity;Brain region;care costs;Characteristics;Clinical;Cognition;Consumption;Data;deviant;Disease;Electroencephalography;Environment;Equity;Exhibits;experience;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Funding;future implementation;Hallucinations;High Frequency Oscillation;Illusions;Image;Impaired cognition;Impairment;improved;Individual;Intervention;Investigation;Magnetism;Measures;Mediating;neural;Neurophysiology - biologic function;neuroregulation;Occipital lobe;Perception;Perceptual distortions;Perceptual disturbance;Performance;Persons;Photic Stimulation;precision neuromodulation;Process;Psychopathology;Psychoses;psychotic;Psychotic Disorders;Research;Research Personnel;Resource Allocation;response;Rest;Role;Sampling;Schizophrenia;Severities;Speed;Stimulus;symptomatology;Symptoms;Task Performances;Techniques;Testing;Thalamic structure;Time;time use;treatment optimization;treatment response;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;Visual;visual information;Visual Perception;visual processing;visual stimulus;Waxes;Work

PROJECT_TITLE: Deviant Synchronization of Neural Functions in Schizophrenia


ADMINISTERING_IC: EY

ARRA_FUNDED: N

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: Goleta

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: PRAEVIUM RESEARCH, INC.

ORG_STATE: CA

PHR: This program will develop high performance optical coherence tomography (OCT) imaging technologies that will enable high resolution, three-dimensional spatial mapping of blood oxygenation in human retinal vasculature. This new imaging technology has the potential to improve early detection and monitoring of many ocular diseases, including diabetic retinopathy, glaucoma and age-related macular degeneration. Wider commercial availability of this high-performance OCT technology promises to accelerate fundamental research as well as clinical studies.

PI_NAMEs: JAYARAMAN, VIJAYSEKHAR  (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: 3-Dimensional;absorption;Acceleration;Age related macular degeneration;Air;Amplifiers;Angiography;Biological Markers;Blood;Blood capillaries;Blood flow;Calibration;Clinical;Clinical Research;cohort;commercialization;deoxyhemoglobin;design;Detection;Development;diabetic;Diabetic Retinopathy;Early Diagnosis;Engineering;Eye;Eye diseases;fabrication;Frequencies;Functional Imaging;fundamental research;Future;gallium arsenide;Generations;Glaucoma;Grant;heterodyning;Human;Image;imaging study;Imaging technology;improved;Indium;innovation;instrument;Investigation;Lasers;Length;Light;lithium niobate;manufacture;manufacturing technology;Maps;Massachusetts;Measurement;Methods;Microscope;Monitor;multidisciplinary;next generation;Noise;novel;operation;Optical Coherence Tomography;Optics;Oxygen;Oxygen saturation measurement;Oxyhemoglobin;Pathogenesis;Patients;Performance;Phase;programs;Research;Resolution;Retina;Retinal Diseases;retinal imaging;Scanning;second harmonic;Semiconductors;Shapes;Signal Transduction;Small Business Innovation Research Grant;Source;Speed;Surface;System;Systems Development;Technology;Testing;United States National Institutes of Health;Visualization;waveguide;Width;Work

PROJECT_TITLE: Swept source retinal visible optical coherence tomography using broadly tunable frequency doubling of NIR MEMS-VCSELs


FUNDING_MECHANISM: OTHERS

ORG_CITY: White River Junction

ORG_NAME: WHITE RIVER JUNCTION VA MEDICAL CENTER

ORG_STATE: VT

PHR: While the VA has made considerable progress in predicting and preventing suicide for patients at the highest risk—including those who previously attempted suicide, were recently released from inpatient mental health treatment, or use opioids—no comparable achievements have been made for patients in lower-risk tiers. Indeed, even though they constitute the vast majority of VA suicide deaths, very little is known about VA patients who die by suicide but are not identified as being at high-risk by existing programs. The proposed study is highly relevant to Veterans’ health because it will advance epidemiological understanding and targeted prediction and prevention resources for these non-high-risk suicide decedents. This work would be highly scalable and could have a large positive impact on Veterans’ health by preventing suicide in patients whose risk otherwise would go undetected. The proposed research is highly relevant to the VA’s top clinical priority, aiding development of accurate and effective suicide prevention services that reach deeper into the risk pool.

PI_NAMEs: LEVIS, MAXWELL ELI JOSHUA (contact)

PROJECT_TERMS: Accounting;Achievement;Adult;Age;Area;associated symptom;Award;Big Data;Big Data Methods;career;career development;Cessation of life;Classification;classification algorithm;Clinical;Clinical Research;Clinical Sciences;Data;Data Set;data warehouse;deep learning;demographics;Development;dexterity;Education;Electronic Health Record;Epidemiology;Evaluation;evidence base;Exclusion;experience;Feeling suicidal;Future;Goals;Health;high risk;improved;Individual;innovation;Inpatients;Intervention;Investigator-Initiated Research;K-Series Research Career Programs;Location;Machine Learning;machine learning classification;machine learning method;Mental Health;Mentors;Mentorship;Modeling;Natural Language Processing;opioid use;Patients;Pharmacotherapy;Population;population based;prediction algorithm;predictive modeling;Prevention;Prevention Research;prevention service;Prevention strategy;Preventive measure;Preventive service;programs;Psychotherapy;public education;reducing suicide;Research;research and development;Research Personnel;Research Proposals;Research Support;Resources;response;Risk;Risk Factors;risk prediction model;Sampling;Services;sex;skill acquisition;skills;Societies;statistics;Structure;suicidal morbidity;suicidal patient;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Symptoms;Testing;Text;Time;time use;Training;Treatment Efficacy;Treatment Factor;United States;United States Department of Veterans Affairs;unstructured data;Veterans;Work

PROJECT_TITLE: Using big data to develop universal and selective suicide prevention strategies


ORG_CITY: WEST HAVEN

ORG_NAME: VA CONNECTICUT HEALTHCARE SYSTEM

ORG_STATE: CT

PHR: This Career Development Award (CDA)-2 proposal will offer comprehensive training in psychiatric genetics for Dr. Peter Na to advance his research skills to become an independent VA researcher. The proposed research project will investigate environmental (e.g., adverse childhood experiences), and psychosocial (e.g., purpose in life, social support) (EP) factors that moderate the genetic liability for substance use disorders (SUDs) in Veterans using polygenic risk scores derived from large genome-wide association studies (GWAS). Further, the proposed study will advance our understanding of the biopsychosocial etiology of SUDs using cutting-edge genetic research methodologies such as epigenetic, gene enrichment and drug-repositioning analyses. The moderating EP factors identified in the study will elucidate targets for clinical interventions to prevent and treat SUDs in Veterans and ultimately help guide VHA clinical practices.

PI_NAMEs: NA, PETER  (contact)

PROJECT_TERMS: addiction;Address;adverse childhood events;Affect;Alcohol consumption;alcohol use disorder;Animals;Area;Award;Biological;Biological Process;biopsychosocial;candidate identification;career;Childhood;Chronic;Clinical;clinical practice;Clinical Research;Cocaine use disorder;cohort;Data;Data Set;Disabling;Disease;disorder risk;DNA Methylation;drug repurposing;Drug usage;Drug Use Disorder;Education;Educational workshop;Environmental Risk Factor;Epidemiology;Epigenetic Process;Etiology;experience;follow-up;functional genomics;Genes;Genetic;Genetic Research;Genetic Risk;genetic variant;genome wide association study;genome-wide;Grant;Health;healthcare burden;Institution;Intervention;K-Series Research Career Programs;Knowledge;large datasets;Life;Literature;Longitudinal cohort;Machine Learning;marijuana use disorder;Measures;Mentors;Mentorship;Methods;military veteran;Molecular;novel therapeutics;opioid use disorder;optimism;Personality Character;Pharmaceutical Preparations;Phenotype;Pilot Projects;polygenic risk score;precision medicine;Predisposition;prevent;Prevention;Process;programs;protective factors;Psychiatric epidemiology;psychiatric genomics;Psychiatrist;psychogenetics;psychosocial;Psychosocial Factor;Public Health;Research;Research Methodology;Research Personnel;Research Priority;Research Project Grants;resilience;Risk;Risk Factors;Role;Sampling;skills;Social support;statistics;Structure;substance use;Substance Use Disorder;Testing;Training;training project;Transition Career Development Award (K22);Universities;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Understanding the role of modifiable environmental and psychosocial factors in moderating genetic risk for substance use disorders in Veterans


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: SEATTLE

ORG_NAME: INSTITUTE FOR SYSTEMS BIOLOGY

ORG_STATE: WA

PHR: Overall Narrative The proposed U54 program Spatiotemporal Tumor Analytics for Guiding Sequential Targeted-Inhibitor -- Immunotherapy Combinations (ST-Analytics) is designed to develop the recent conceptual advance that targeted inhibitor + cancer immunotherapy (IT) combination treatments may yield significantly greater patient benefit if those treatments are administered in sequence rather than as monotherapies or as simultaneously administered combinations.

PI_NAMEs: HEATH, JAMES R. (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Acceleration;Address;Adoptive Cell Transfers;Algorithms;Automobile Driving;biobank;Biological;Biopsy;Calibration;cancer immunotherapy;Cell Physiology;Cells;Clinical;Clinical Data;Clinical Trials;Clinical Trials Design;Combination immunotherapy;combinatorial;Combined Modality Therapy;Communities;computing resources;Coupled;Data;Databases;demographics;design;Development;Dimensions;Disadvantaged;disease model;Distal;Dose;Education and Outreach;Educational Models;Environment;Environment Design;Epigenetic Process;Evaluation;Genetic Transcription;Immune;immune checkpoint blockade;Immune system;Immunologic Factors;Immunooncology;Immunotherapy;in silico;in vivo;Individual;inhibitor;inhibitor therapy;Internships;K-12 Education;Kinetics;Knowledge;Lead;Leadership;Malignant Neoplasms;Measurement;medical schools;Melanoma;Metastatic malignant neoplasm to brain;Mitogen-Activated Protein Kinase Inhibitor;model design;Modeling;mouse model;multiple omics;Nature;Neoplasm Metastasis;Outcome;outreach;outreach program;Patients;Pharmaceutical Preparations;Pilot Projects;Play;prevent;Primary Neoplasm;programs;Proteomics;recruit;Research;Research Personnel;Research Project Grants;Resistance;Resources;Role;Science;Science, Technology, Engineering and Mathematics Education;Scientist;Self-Examination;Series;spatiotemporal;Structure;System;Systems Biology;Therapeutic;Time;Tissues;tool;transcriptomics;tumor;tumor-immune system interactions;Visual;Work

PROJECT_TITLE: Spatiotemporal Tumor Analytics for Guiding Sequential Targeted-Inhibitor: Immunotherapy Combinations (ST-Analytics)


ED_INST_TYPE: SCHOOLS OF NURSING

ORG_CITY: GAINESVILLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE – OVERALL COMPONENT The long term goals of the CaRE2 center are to reduce cancer disparities in Black/African American and Hispanic/Latinx individuals, to train and increase the pool of 120 underrepresented Black/African American and Hispanic/Latinx scientists conducting health disparity research, to increase research capacity at an HBCU (FAMU), and to increase cancer disparity research at UF and USC-NCCC. The proposed two full projects and pilot project include investigators from the three institutions and will leverage on specimens collected across the partnership from Black/African American and Hispanic/Latinx, representing a wide range of subpopulations within these minority groups. Thus, our studies will reveal unprecedented findings about these two understudied minority populations, will be instrumental in transferring cutting edge and innovative technologies to FAMU, and will expand in a significant way the research focus at UF and USC-NCCC to address cancer health disparities in pancreas and lung cancers.

PI_NAMEs: HUGHES-HALBERT, CHANITA A.;REAMS, ROMONIA RENEE;REDDA, KINFE KEN;STERN, MARIANA C;WILKIE, DIANA J (contact)

PROGRAM_OFFICER_NAME: BARFIELD-STEWARD, WHITNEY

PROJECT_TERMS: Address;Advocate;African;African American;American;anti-cancer research;Award;Back;Benchmarking;Bioinformatics;Biological;Biological Models;Biomedical Research;Black American;Black Populations;Black race;California;Cancer Center;Cancer Control;cancer health disparity;Cancer Model;Cancer Patient;cancer prevention;career development;Caribbean region;Caring;Catchment Area;Censuses;Central American;Communities;Community Outreach;community partnership;Complex;Comprehensive Cancer Center;Cultural Diversity;Development;Disparity;disparity reduction;Doctor of Philosophy;drug development;Education;education research;Educational Materials;Effectiveness;Evaluation;Extramural Activities;Florida;Fostering;Funding;genetic makeup;genome resource;Goals;Grant;Health;Health Disparities Research;health disparity populations;health equity;Heterogeneity;Hispanic;improved;improved outcome;Incidence;Individual;Infrastructure;innovation;innovative technologies;Institution;Latino;Latino Population;Latinx;Latinx population;Leadership;Location;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;meetings;member;Mentors;Methodology;Methods;Mexican Americans;Minority;minority communities;Minority Groups;minority patient;minority trainee;mortality;novel anticancer drug;Outcome;outreach;patient population;Pilot Projects;podcast;Population;Population Heterogeneity;Postbaccalaureate;Postdoctoral Fellow;Process;programs;Publications;Publishing;Reporting;repository;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Training;Resource Sharing;Resources;Scientist;Series;social determinants;South American;Specimen;Students;success;Tissue Model;tool;Training;Training and Education;translational cancer research;Translational Research;Underrepresented Minority;Underrepresented Students;Underserved Population;understudied cancer;United States;Universities;University of Southern California Norris Cancer Center;US State;Use Effectiveness;Work

PROJECT_TITLE: 2/3 Florida-California Cancer Research, Education and Engagement (CaRE2) Health Equity Center


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Orphan Drug;Racial and Ethnic Minority Health Research;Rare Diseases;Tobacco;Tobacco Smoke and Health

PI_NAMEs: HUANG, YONG  (contact)

PROJECT_TERMS: 3-Dimensional;Address;Affect;African American;African American population;alpelisib;Alveolar;alveolar epithelium;Amides;Angiogenesis Inhibition;anti-cancer therapeutic;BAY 54-9085;Bioinformatics;Biological;Biological Factors;Biological Models;Biomedical Engineering;Black American;black men;Black Populations;Black race;black women;bone;BRAF gene;Bronchiolo-Alveolar Adenocarcinoma;California;cancer cell;cancer health disparity;Carcinogens;Caring;Cell Line;Cell Survival;Cells;Collection;Combined Modality Therapy;cytotoxicity;Data Analyses;Development;Disparity;DNA;Doctor of Philosophy;driver mutation;Drug Combinations;drug development;effective therapy;Epidermal Growth Factor Receptor;Epithelial Cells;Erlotinib;Ethnic Origin;Ethnic Population;exome sequencing;exposure to cigarette smoke;Florida;follow-up;Formalin;Funding;Gel;Gelatin;Gene Mutation;Genes;Genetic;Growth;health disparity;high risk;In Vitro;in vitro Model;Individual;Inhalation;inhibitor;innovation;interdisciplinary collaboration;Invaded;Knowledge;KRAS2 gene;Leukocytes;Lung Adenocarcinoma;Malignant Bone Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;MAP Kinase Gene;Measures;Medicine;member;men;Metabolism;Metastatic Neoplasm to the Bone;Methodology;Methods;migration;Modeling;Molecular;mutant;Mutate;Mutation;Neoplasm Metastasis;neoplasm registry;Nicotine;novel;novel therapeutics;Organoids;osteogenic;Paraffin Embedding;Pathway interactions;Patients;Pattern;Perfusion;Pharmaceutical Preparations;PIK3CG gene;Porosity;Printing;progenitor;Race;racial difference;racial population;Resources;response;Risk Factors;Sampling;Site;Source;STK11 gene;System;targeted treatment;Testing;Therapeutic;therapeutic evaluation;therapeutic target;Time;Tissue Model;Tobacco smoke;tool;TP53 gene;Treatment Efficacy;treatment response;two-dimensional;Variant;Vascular Endothelial Cell;Woman;Work

PROJECT_TITLE: Project 4 LUNG


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Breast Cancer;Cancer;Gene Therapy;Genetics;Immunotherapy;Neurosciences;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE  Breast cancer brain metastasis (BCBM) is associated with deadly outcomes due to limited therapeutic options and poor response, urgently calling for the development of novel therapeutic intervention strategies. We have found that oncolytic herpes simplex virus-1 (oHSV) therapy induces neutrophil infiltration and neutrophil extracellular trap (NET) formation through induction of Insulin-like growth factor-2 (IGF2) expression and secretion into tumor microenvironment (TME), hampering therapeutic efficacy of oHSV. In this proposed research, we will uncover the mechanistic relationship between oHSV-induced IGF2 and oHSV-triggered neutrophil infiltration and NET in BCBM, and characterize the preclinical therapeutic impact of novel IGF2- scavenging oHSV in combination with radiation therapy as well as NET-mitigating oHSV for significant advance of BCBM treatment in the future clinical application.

PI_NAMEs: YOO, JI YOUNG  (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Acceleration;Actins;Acyclovir;Address;advanced breast cancer;anti-tumor immune response;Anti-viral resistance;Breast Cancer Patient;cancer cell;Cancer Patient;cancer type;Clinical;clinical application;Clinical Data;Complex;cytotoxic;Development;Diagnostic Imaging;extracellular;FDA approved;Future;Generations;Glioblastoma;Goals;Hyperactivity;Immune Evasion;Immunity;immunotherapeutic virotherapy;Immunotherapy;improved;In Vitro;in vivo;Incidence;Infiltration;Inflammatory;inhibitor;Injectable;Insulin-Like Growth Factor II;Intervention;Japan;Lymphocyte;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Melanoma;Metastatic malignant neoplasm to brain;Microglia;Modality;Modeling;Mus;neoplastic cell;neutrophil;Neutrophil Infiltration;novel;novel therapeutic intervention;oncolytic herpes simplex virus;Outcome;Patients;pre-clinical;pre-clinical assessment;preclinical efficacy;prevent;Quality of life;Radiation therapy;Research;Resistance;resistance mechanism;response;Role;Safety;Signal Pathway;Survival Rate;synergism;Systemic Therapy;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Time;Translations;Treatment Efficacy;tumor;tumor heterogeneity;Tumor Immunity;tumor microenvironment;tumor progression;tumor-immune system interactions;Viral;Virotherapy;Virus;Virus Replication

PROJECT_TITLE: Enhanced Viro-Immunotherapy for Breast Cancer Brain Metastasis

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


ADMINISTERING_IC: AG

ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Alzheimer’s disease and Alzheimer’s disease-related dementias (AD/ADRD) are a major public health problem, and identifying the causes is a priority for research. This project will quantify the impact of a common exposure, traumatic stress, to improve understanding of AD/ADRD etiology. In addition, the work will identify factors that exacerbate or ameliorate effects of traumatic stress across the lifecourse on AD/ADRD risk, which will inform high-risk groups and opportunities for intervention to prevent AD/ADRD.

PI_NAMEs: HAYES-LARSON, ELEANOR LOUISE (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Acceleration;Address;Adult;Affect;African American population;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Award;Biological Markers;Biometry;Black American;Brain;brain health;career;Characteristics;Child;childhood adversity;Clinical;Cognition;Cognitive;Cognitive aging;cohort;Data;Data Pooling;Data Set;Dementia;dementia burden;dementia risk;Disparity;Education;Epidemiology;Ethnic Origin;Etiology;experience;Exposure to;Foundations;Gender;Health;Health and Retirement Study;healthy aging;Heterogeneity;high risk population;Image;Impaired cognition;improved;Individual;Intervention;Knowledge;late life;Life;Life Cycle Stages;Life Experience;Machine Learning;Measures;Mentorship;Methods;middle age;Modeling;Neurocognitive;neuroimaging;neuroimaging marker;Neurological outcome;Outcome;Pathology;Pathway interactions;pediatric trauma;Physical activity;Population Heterogeneity;prevent;Psychopathology;psychosocial;Psychosocial Factor;Public Health;Race;Research;Research Priority;resilience;resilience factor;Science;Security;sex;skills;social;Social Network;Social support;Societal Factors;sociodemographic group;Statistical Methods;Stress;Stress Tests;Subgroup;Symptoms;Training;Trauma;trauma exposure;traumatic event;traumatic stress;treatment effect;Woman;Work

PROJECT_TITLE: Effects of lifecourse traumatic stress on late-life cognitive decline, dementia, and neuroimaging biomarkers

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alcoholism, Alcohol Use and Health;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Chronic Liver Disease and Cirrhosis;Dementia;Digestive Diseases;Liver Disease;Neurodegenerative;Neurosciences;Substance Misuse

ORG_CITY: CLAREMONT

ORG_NAME: KECK GRADUATE INST OF APPLIED LIFE SCIS

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) is the sixth leading cause of death in the United States with approximately 5.8 million Americans living with AD. Many studies show a positive association between heavy alcohol consumption and AD development and progression. Our proposal explores how chronic alcohol consumption affects the liver and brain to induce and/or exacerbate AD.

PI_NAMEs: HAN, DERICK S (contact);SUMBRIA, RACHITA

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Abeta clearance;AD transgenic mice;Affect;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol research;Alcohol-Induced Disorders;Alcoholic Liver Diseases;Alcohols;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;American;Amyloid beta-Protein;Area;Biological Products;Blood - brain barrier anatomy;Blood brain barrier dysfunction;blood-brain barrier permeabilization;Brain;brain health;Cause of Death;Cerebral endothelium;Chimeric Proteins;Chronic;chronic alcohol ingestion;Data;Deposition;Development;Dichloromethylene Diphosphonate;Down-Regulation;Etanercept;Fc(alpha) receptor;feeding;Goals;Hepatic;Homeostasis;In Vitro;in vivo;Inflammation;insight;Knowledge;knowledge of results;Kupffer Cells;Lipoprotein Receptor;Liposomes;Liver;liver function;liver injury;Low Density Lipoprotein Receptor;Mediating;Metabolic;migration;Modeling;Mus;Nerve Degeneration;Neurofibrillary Tangles;neuroinflammation;Neuronal Injury;neurovascular;new therapeutic target;novel;old mice;Organ;overexpression;Pathology;Peripheral;Plasma Proteins;problem drinker;receptor;receptor for advanced glycation endproducts;Research;Role;Source;Specialist;success;synergism;tau Proteins;Techniques;Testing;TNF gene;TNFRSF1A gene;United States;wasting;Work

PROJECT_TITLE: Modulation of the liver-brain axis by alcohol and its impact on Alzheimers disease pathology


ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;HIV/AIDS

ORG_CITY: BOSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: Contact PD/PI: Fawzi, Wafaie W Project Narrative The HBNU Fogarty Global Health Training Program, a consortium of Harvard University, Boston University, Northwestern University and the University of New Mexico, proposes to continue to contribute to global health research capacity building and the use of research to improve the health outcomes related to priority health areas in low- and middle-income countries (LMICs) in partnership with 18 sites throughout Africa, Asia, and South America. The Program will recruit US and LMIC trainees to strengthen global health research networks and programs at academic institutions and ultimately help sustain global health research in the US and LMICs. Project Narrative Page 8

PI_NAMEs: FAWZI, WAFAIE W (contact);HAMER, DAVIDSON HOWES;HAWKINS, CLAUDIA A;PERKINS, DOUGLAS JAY

PROGRAM_OFFICER_NAME: KATZ, FLORA N

PROJECT_TERMS: Award;Biomedical Research;Boston;Cardiovascular Diseases;career;co-infection;Collaborations;Competence;Creativeness;Diabetes Mellitus;Discipline;Disease;E-learning;Education;Evaluation;experience;Fostering;Future;Future Generations;global health;HIV/AIDS;Individual;Institution;Interdisciplinary Study;International;Investments;low and middle-income countries;Malignant Neoplasms;Maternal and Child Health;medical schools;member;Mental Health;Mentors;Morbidity - disease rate;mortality;New Mexico;next generation;nutrition;Output;Peer Review;Persons;Postdoctoral Fellow;pre-doctoral;Principal Investigator;programs;Public Health Schools;Publications;Qualifying;Readiness;recruit;Research;research and development;Research Design;Research Methodology;Research Project Grants;Research Support;Research Training;Scientist;Site;Students;symposium;tool;Training;Training Programs;Underrepresented Populations;United States National Institutes of Health;Universities

PROJECT_TITLE: Launching Future Leaders in Global Health (LAUNCH) Research Training Program - Supplement for OAR


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PI_NAMEs: LUNN, MITCHELL RYAN (contact);OBEDIN-MALIVER, JUNO

PROGRAM_OFFICER_NAME: JAMES, SHEILA LENETTE

PROJECT_TERMS: Academy;African;African American;Age;All of Us Research Program;Annual Reports;biological heterogeneity;Birth;Caring;Caucasians;Censuses;Cities;citizen science;Clinical;Collection;Communities;Consensus;County;Data;design;Discrimination;Enrollment;Ensure;Equity;Ethnic Origin;Etiology;experience;Gender Identity;gender minority;gender minority community;gender minority group;gender minority health;gender minority health research;Geographic Distribution;Geography;Goals;Health;health care availability;health care disparity;health disparity;health disparity populations;Health Personnel;Health Status;Hispanic;HIV Infections;Income;Individual;Inequity;Institute of Medicine (U.S.);Intervention;Language;Legal;Lesbian Gay Bisexual;Lesbian Gay Bisexual Transgender;Lesbian Gay Bisexual Transgender Queer;Linguistics;Malignant Neoplasms;maltreatment;Manuscripts;marginalization;Measures;Medicine;member;Mental Depression;Minority Groups;minority patient;minority stress;National Health and Nutrition Examination Survey;National Health Interview Survey;Personal Satisfaction;Persons;Politics;Population;population based;Population Study;Race;Recommendation;Reporting;Research;Research Personnel;Sampling;San Francisco;Science;sex assigned;Sex Orientation;Sexual and Gender Minorities;sexual minority;sexual minority group;Smoking;social;Societies;socioeconomics;Stigmatization;Suicide attempt;Training;Underrepresented Minority;Underserved Population;United States;United States National Center for Health Statistics;United States National Institutes of Health

PROJECT_TITLE: PRIDEnet for the All of Us Research Program


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety;Prevention

ORG_CITY: CHICAGO

ORG_NAME: ALLIANCE NCTN FOUNDATION

ORG_STATE: IL

PHR: PROJECT NARRATIVE The Alliance NCI Community Oncology Research Program (NCORP) Research Base conducts research in cancer prevention, cancer symptom control, and cancer care delivery with a special emphasis on minority, underserved, and older patients and with a strong commitment to building collegial relationships with NCORP Community sites and Minority/Underserved Community sites. The Alliance NCORP seeks to continue its mission into the next grant cycle of generating practice-changing research that directly and favorably impacts the lives of cancer patients and those at risk for cancer.

PI_NAMEs: GALANIS, EVANTHIA ;HAHN, OLWEN ;PASKETT, ELECTRA D. (contact)

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: Academic Medical Centers;Address;Advocate;Area;base;Blood;cancer care;cancer clinical trial;Cancer Patient;cancer prevention;cancer risk;cancer therapy;care delivery;chemotherapy;Clinical;Clinical Oncology;Clinical Research;Clinical Trials;Collaborations;Collection;Committee Membership;Communities;Community Clinical Oncology Program;data sharing;Databases;Diagnosis;Funding;Grant;Human;innovation;Intervention;Malignant Neoplasms;Manuscripts;Mentorship;Metastatic malignant neoplasm to brain;Metastatic Neoplasm to the Bone;Minority;Mission;National Clinical Trials Network;Nausea and Vomiting;older patient;Oncology;Parents;Patient Outcomes Assessments;Patients;premalignant;Prevention;programs;Publishing;Quality of life;repository;Research;Research Personnel;Risk;Site;skeletal-related events;Source;Symptoms;Tissue Sample;Training;translational oncology;Translational Research;treatment trial;Tumor Tissue;underserved community;United States;Work

PROJECT_TITLE: Alliance NCORP Research Base - BIQSFP A211901 GY11 Supplement


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Pediatric;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: TALLAHASSEE

ORG_DEPT: CHEMISTRY

ORG_NAME: FLORIDA STATE UNIVERSITY

PHR: Acute lower respiratory infection (ALRI) is a predominant cause of morbidity and mortality worldwide. Respiratory viruses are the major cause of ALRI, with influenza virus, SARS-CoV-2, respiratory syncytial virus, human metapneumovirus, and the parainfluenza viruses causing the major burden. Our major objective is to define the structural and mechanistic determinants mediating the neutralization and protection against paramyxoviruses, with a specific focus on the parainfluenza viruses.

PI_NAMEs: MOUSA, JARROD  (contact)

PROGRAM_OFFICER_NAME: KIM, SONNIE

PROJECT_TERMS: 2019-nCoV;5 year old;Acute;Adult;Advanced Development;Age;Antibodies;B cell repertoire;B-Lymphocytes;Binding;candidate identification;Cessation of life;Child;Chimeric Proteins;Collaborations;Cotton Rats;cross reactivity;Cryoelectron Microscopy;Data;Death Rate;Disease;disorder prevention;Epitopes;Family;Future;Generations;Glycoproteins;Grant;Hemagglutinin;Hematologic Neoplasms;Hematopoietic stem cells;High-Throughput Nucleotide Sequencing;Hospitalization;Human;Human Metapneumovirus;human monoclonal antibodies;Immunodominant Epitopes;infectious disease treatment;influenzavirus;innovation;Laboratories;Laboratory Research;Life Cycle Stages;Lower Respiratory Tract Infection;Mediating;member;Membrane Proteins;Mesocricetus auratus;Molecular;Molecular Conformation;Monoclonal Antibodies;Morbidity - disease rate;mortality;National Institute of Allergy and Infectious Disease;Neuraminidase;neutralizing monoclonal antibodies;Organ Transplantation;pandemic potential;parainfluenza virus;Parainfluenza Virus Infections;Paramyxovirus;Prevention;protective efficacy;Proteins;receptor binding;Receptor Inhibition;Research;Respiratory syncytial virus;Respiratory Syncytial Virus Vaccines;respiratory virus;response;Rodent Model;screening;Solid;Specificity;Structure;success;Therapeutic;Therapeutic Monoclonal Antibodies;tool;Translating;vaccine access;vaccine candidate;Vaccine Design;vaccine development;Vaccines;Viral;Virus;Virus Diseases;Zoonoses

PROJECT_TITLE: Antibody recognition of paramyxovirus surface proteins

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: NEW YORK

ORG_DEPT: PEDIATRICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Measles (MeV) causes a severe transient immunosuppression in healthy individuals and can cause lethal encephalitis in immunocompromised people. The current live vaccine virus is effective but requires low temperature for transport and cannot be used in severely immune compromised individuals. Recent advances in our MeV research are ready to be applied to developing a new vaccine strategy that will lead to a thermostable subunit vaccine that will also be safe for the severely immune compromised individuals.

PI_NAMEs: POROTTO, MATTEO  (contact);SAPHIRE, ERICA OLLMANN

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Active Immunization;Acute;Amnesia;Antigens;Attenuated;Attenuated Vaccines;base;Cell Culture Techniques;Cells;Cellular Immunity;Central Nervous System Infections;Child;Chimeric Proteins;Clinical;Cold Chains;cold temperature;Collaborations;Communicable Diseases;Complex;conformational conversion;Contracts;Coupled;COVID-19 pandemic;Data;design;Developing Countries;Disease;Disease Outbreaks;editorial;efficacy evaluation;emerging virus;Encephalitis;Engineering;Fetus;Glycoproteins;Grant;Hemagglutinin;Herd Immunity;High temperature of physical object;Home;Hospitalization;Immune;Immune response;Immune system;Immunity;Immunization;Immunocompromised Host;immunogenic;Immunology;Immunosuppression;Impairment;improved;in vivo;Individual;Infection;Infectious Agent;Joints;Kinetics;Knowledge;Length;Measles;Measles Vaccine;Measles virus;Medical center;Membrane;Membrane Fusion;Membrane Glycoproteins;Molecular Conformation;Mothers;Mutation;National Institute of Allergy and Infectious Disease;nectin;Neurologic;neutralizing antibody;novel vaccines;Ohio;Passive Immunization;Persons;Play;Pneumonia;Predisposition;Pregnant Women;Proteins;Publishing;receptor;Recombinants;Reporting;Research;Respiratory syncytial virus;Respiratory Tract Infections;Risk;Role;Route;SLAM protein;Structure;Subunit Vaccines;Testing;thermostability;United States;Universities;Vaccinated;Vaccination;vaccination strategy;Vaccine Design;vaccine immunogenicity;vaccine strategy;Vaccines;Vertical Transmission;Viral;Viral Physiology;Virus;Work

PROJECT_TITLE: Thermostable measles fusion glycoprotein as a new vaccine strategy

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Nashville

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE The long-term goal of the proposed research is to understand mechanisms of ribosome assembly, its quality control as well as the consequences of their failure, when misassembled ribosomes escape into the translating pool, leading to diseases phenotypes. These questions will be addressed in a combination of biochemical, genetics, genomics and structural tools, largely using yeast as a model organism, but addressing questions of disease-relevance in human cells.

PI_NAMEs: KARBSTEIN, KATRIN  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Address;Affect;Biochemical;Biogenesis;cancer cell;Cells;Cellular biology;conformational conversion;Degradation Pathway;Disease;disease phenotype;Ensure;Failure;frontier;Genetic;Genomics;Goals;Head;Human;human disease;insight;Link;Mediating;Messenger RNA;model organism;Molecular Biology;novel;Pathway interactions;Protein Biosynthesis;Proteins;proteostasis;Quality Control;Regulation;Research;Ribosomal Proteins;Ribosomes;RNA Folding;Role;Structure;System;tool;Translating;Work;Yeasts

PROJECT_TITLE: Dissecting the Mechanisms of Regulation and Quality Control in Ribosome Assembly and the Consequences of their Failure

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Antimicrobial Resistance;Digestive Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project Narrative The goal of the research is to improve derivatives of oxamniquine (OXA) that are cidal against all human schistosomes, not just S. mansoni. We have identified a OXA derivative that will kill S. mansoni, S. haematobium and S. japonicum adult and liver stage worms as well as praziquantel resistant worms in in vivo assays. The purpose is to provide a second drug to be used in combination with praziquantel that will improve efficacy and mitigate resistance.

PI_NAMEs: ALWAN, SEVAN NAJM;CAMERON, MICHAEL DARIN;LOVERDE, PHILIP T (contact);MCHARDY, STANTON FURST

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: absorption;Adult;Affect;Africa South of the Sahara;Animal Model;Animals;Anthelmintics;Appearance;aqueous;Binding Proteins;Biological Assay;Biological Availability;Caco-2 Cells;chemical property;chemical synthesis;chemotherapy;Clinical Research;Combined Modality Therapy;Data;design;Development;Disease;Dose;drug discovery;Drug resistance;drug resistant pathogen;efficacy study;efficacy testing;egg;Engineering;Enzymes;Esterification;Excretory function;Exhibits;experimental study;Formulation;Generations;Goals;Hamsters;Health;Hepatocyte;Human;improved;In Vitro;in vitro Assay;in vivo;in vivo Model;Infection;innovation;Intestines;Laboratories;Liver;Measures;Metabolic;Metabolism;Methods;Microsomes;Modeling;Morality;Morbidity - disease rate;mortality;Mus;neglected tropical diseases;next generation;novel;novel therapeutics;Oral;Outcome;Pan Genus;Parasite resistance;Permeability;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phase;Portal vein structure;Praziquantel;Praziquantel resistance;pre-clinical;Preclinical Testing;pressure;prevent;Process;Prodrugs;Production;programs;Property;Research;Resistance;resistant strain;response;Safety;scale up;Schistosoma;Schistosoma japonicum;Schistosoma mansoni;Schistosome Parasite;Schistosomiasis;screening;Series;Solubility;Structure;sulfotransferase;Testing;Toxic effect;transmission process;Treatment Efficacy;Weight;Work

PROJECT_TITLE: Preclinical Testing of Potential Next-generation Antischistosomal Compounds


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Orphan Drug;Pediatric;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: Columbus

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Current acellular pertussis vaccines do not prevent nasal colonization or transmission of B. pertussis, highlighting the need for next-generation vaccines that generate mucosal immunity. Here we will test a novel booster vaccine for adults and a novel pediatric vaccine that incorporates novel CD4+ T cell recognized antigens from B. pertussis that generate tissue-resident T cells in the nose and lungs. We hypothesize that these vaccines will reduce nasal colonization in individuals previously immunized with acellular pertussis vaccines and prevent development of a B. pertussis nasal reservoir in infants who are immunized this new formulation.

PI_NAMEs: DEORA, RAJENDAR K;DUBEY, PURNIMA  (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Acellular Vaccines;Adjuvant;Adolescent;Adult;Antibodies;Antibody Response;Antigen Presentation;antigen-specific T cells;Antigenic Diversity;Antigens;Biological Assay;booster vaccine;Bordetella;Bordetella pertussis;burden of illness;CD4 Positive T Lymphocytes;Cells;Cellular Assay;Child;Childhood;Clinical;Communities;Containment;Coughing;Country;Development;Disease;Disease Outbreaks;draining lymph node;Drug Metabolic Detoxication;efficacy testing;Epitopes;experimental study;factor A;Formulation;functional status;Generations;Goals;high dimensionality;Human;human pathogen;Immune response;Immunity;Immunization;Immunize;immunogenic;immunogenicity;Individual;Infant;Infection;Intradermal Tests;Intramuscular;Laboratories;Longevity;Lower respiratory tract structure;Lung;lung colonization;Mass Spectrum Analysis;MHC Class II Genes;Mucosal Immunity;Mucous Membrane;Mus;mutant;Nasopharynx;next generation;Nose;novel;novel vaccines;Pathogenesis;pathogenic bacteria;Persons;Pertussis;Pertussis Toxin;Pertussis Vaccine;Phagocytes;prevent;protective efficacy;protein purification;Proteins;Publications;recruit;Regimen;Resistance;Resolution;Respiratory System;response;Role;Route;Safety;Spleen;Subunit Vaccines;T cell response;T-Lymphocyte;Testing;tissue resident memory T cell;Tissues;Toxin;transmission process;Upper respiratory tract;Vaccination;Vaccine Adjuvant;Vaccine Antigen;vaccine delivery;vaccine formulation;Vaccinee;Vaccines;vaccinology;Vulnerable Populations;Whole Cell Vaccine;Work

PROJECT_TITLE: Novel B. Pertussis vaccines that elicit mucosal immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-B(02)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Cystic Fibrosis;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases

ORG_CITY: ATLANTA

ORG_DEPT: BIOLOGY

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Project Narrative Microbial cooperative and competition interactions are common, and in pathogenic organisms, often important drivers of biofilm formation and antimicrobial resistance. In the airways of cystic fibrosis patients, Pseudomonas aeruginosa cells frequently grow in freely suspended aggregates, however, the mechanisms that govern the shape and size of bacterial aggregates during infection are not well defined. This project will provide greater understanding of the interplay between physical environmental constraints imposed by polymers, properties of the bacterial cell surface and how these factors impact on aggregate formation, antimicrobial tolerance and quorum sensing-dependent cell-to-cell interactions.

PI_NAMEs: DIGGLE, STEPHEN PAUL (contact)

PROJECT_TERMS: Acute;Age;Alginates;Anabolism;anti-microbial tolerance;Antibiotic Therapy;antibiotic tolerance;Antibiotics;Antigens;Antimicrobial Resistance;Cell Communication;Cell surface;Cells;Chronic;chronic infection;combat;Conflict (Psychology);Cystic Fibrosis;cystic fibrosis airway;cystic fibrosis patients;Cytoprotection;Data;design;Environment;Environmental Risk Factor;experience;fitness;follow-up;Frequencies;Future;Genes;Genetic Diseases;Goals;Heterogeneity;Hydrophobic Surfaces;Hydrophobicity;Immune Evasion;Immune response;Individual;Infection;insight;Invaded;Life;Lipopolysaccharide Biosynthesis Pathway;Lipopolysaccharides;Lung;Lung Diseases;Lung infections;microbial;Microbial Biofilms;microbiome research;Modeling;Modification;Mucins;mutant;Mutation;O Antigens;Organism;pathogenic bacteria;Pathogenicity;Patients;Phenotype;Polymers;Population;Production;Property;Pseudomonas aeruginosa;Pulmonary Cystic Fibrosis;Pulmonary Fibrosis;pulmonary function;pulmonary function decline;quorum sensing;Research;response;Role;Sampling;Serotyping;Shapes;social;Social Behavior;social influence;Social Interaction;Source;Sputum;stressor;Structure;sugar;Surface Properties;Therapeutic Intervention;Time;trait;treatment planning;Variant;Work

PROJECT_TITLE: Deciphering How Bacterial Surface Properties Influence Social Behaviors

STUDY_SECTION: IMII

STUDY_SECTION_NAME: Interspecies Microbial Interactions and Infectious Study Section[IMII]


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Herpes simplex virus causes infection in mucosal epithelial cells and causes lesions and spreads to sensory neurons where it establishes a latent infection, from which it can later reactivate and cause recurrent disease. This application investigates how human host cells attempt to prevent the viral DNA from expressing its genes and how the virus has mechanisms to neutralize this effect. Knowledge of this battle between virus and its host cell will provide opportunities to develop antiviral strategies to combat viral infection and disease.

PI_NAMEs: KNIPE, DAVID M. (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Acyclovir;Afferent Neurons;Area;ATAC-seq;Back;Binding;Bulla;Capsid;Cell Nucleus;Cells;cellular transduction;ChIP-seq;Chromatin;Chromatin Loop;Chromatin Structure;combat;Cytomegalovirus Infections;Cytoplasm;cytotoxicity;Deoxyribonucleases;DNA;DNA biosynthesis;DNA Damage;DNA Virus Infections;DNA Viruses;Drug resistance;Epigenetic Process;epigenetic regulation;epigenetic silencing;Epithelial Cells;Event;Face;Fibroblasts;Gene Expression;Gene Transduction Agent;Genes;Genetic Transcription;genital herpes;Genome;Herpes Simplex Infections;Herpesviridae;Herpesvirus 1;Heterochromatin;histone modification;Hour;Human;Immediate-Early Genes;Immune response;Infection;Insulator Elements;Integration Host Factors;Interferons;Inverted Repeat Sequences;Knowledge;latency associated transcript;latent infection;Lesion;Location;Lytic Phase;Maintenance;Modeling;Mucous Membrane;Normal Cell;Nuclear;Nuclear Envelope;nucleoside analog;Pathway interactions;Pharmaceutical Preparations;prevent;Proteins;Recurrent disease;response;RNA Polymerase II;Role;Sequence Deletion;Signal Transduction;Simplexvirus;Structure;transgene expression;Transgenes;transmission process;TREX1 gene;vector;vector genome;Viral;viral DNA;Viral Genes;Viral Genome;viral genomics;viral resistance;Virion;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Nuclear Sensing of Herpesviral DNA

STUDY_SECTION: VDT

STUDY_SECTION_NAME: Viral Dynamics and Transmission Study Section [VDT]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Physical Injury - Accidents and Adverse Effects;Social Determinants of Health;Substance Misuse;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE This study involves identifying antecedents (i.e., psychological distress, drinking motives, and microaggressions) of heavy drinking in real-time among bisexual and heterosexual women with and without histories of sexual assault. Investigation of antecedents of heavy drinking is of immediate public health importance due to the very high rates of heavy drinking and sexual assault among bisexual women, particularly those with histories of sexual assault. Identifying event-level antecedents will aid in the development of ecological momentary and/or just-in-time interventions to decrease heavy drinking among bisexual women.

PI_NAMEs: LÓPEZ, GABRIELA  (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: Adult;Age;Alcohol abuse;Alcohol consumption;alcohol intervention;Anxiety;Area;assault;binge drinking;Bisexual;Characteristics;Chronic;Clinical;Communities;coping;Data;Data Analyses;depressive symptoms;Development;Discrimination;Disparity;drinking;Ecological momentary assessment;Event;evidence base;experience;Exposure to;Gays;Goals;Heavy Drinking;Heterosexuals;high risk population;improved;Individual;informant;Intervention;Interview;Investigation;Knowledge;Lesbian;Life;Lived experience;Measures;Mediating;Mental Depression;Mentors;Methods;microaggression;minority stress;minority stressor;Minority Women;Modeling;Motivation;neglect;Occupational;Outcome;Pathway interactions;perceived discrimination;Persons;Phase;Play;post-traumatic stress;programs;Protocols documentation;psychologic;psychological distress;Public Health;Publishing;Qualitative Methods;Recording of previous events;Reporting;Research;Risk;Risk Factors;Role;Sample Size;Sampling;Scientist;sexual assault;sexual identity;sexual minority;sexual minority men;sexual minority women;skill acquisition;social stigma;Stress;stressor;Structure;Surveys;Testing;therapy development;Time;Training;Woman;Women's Group;Work

PROJECT_TITLE: Event-level Antecedents of Heavy Drinking Among Bisexual and Heterosexual Women with and without Histories of Sexual Assault


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases;Rare Diseases

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Type III secretion (T3S) is arguably the most important route through which gram-negative animal pathogens cause disease in humans. The characterization of secretion-substrate recognition and the T3S-specificity switch for the Salmonella injectisome systems will further our understanding of host-pathogen interactions, protein- secretion specificity, nanomachine self-assembly and coupled gene regulatory mechanisms. These complex mechanisms provide a wealth of potential therapeutic targets to inhibit T3S-associated pathogenesis.

PI_NAMEs: HUGHES, KELLY T (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Amino Acids;Animals;antimicrobial;Antimicrobial Resistance;Bacteria;Bacterial Proteins;base;beta-Lactamase;Binding Sites;Biogenesis;Biology;Cell membrane;Cell Physiology;Cells;Characteristics;Chlamydia;Chromosome Mapping;Chromosomes;Codon Nucleotides;colicin;Complex;Coupled;Couples;Cytoplasm;Cytoplasmic Protein;Cytoskeleton;Disease;Docking;Drug Design;Drug Targeting;Dysentery;Ensure;Experimental Designs;experimental study;field study;fighting;Gastroenteritis;Gene Expression Regulation;Genes;Genetic;genetic approach;Genetic Screening;genetic selection;Goals;Health;Human;human pathogen;hypodermic needle;Infection;insight;Knowledge;Length;Measures;Membrane;Methods;migration;Molecular;Molecular Conformation;Molecular Machines;Motility;nanomachine;next generation sequencing;novel;novel therapeutics;Organelles;Organism;Outcome;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity Island;Pathway interactions;Peptide Signal Sequences;Peptides;Plague;Plants;preference;Prevention;Process;Protein Secretion;Proteins;Pseudomonas;Qualifying;Randomized;Reporter;Research;Route;Salmonella;Salmonella infections;screening;self assembly;Sexually Transmitted Diseases;Shigella;Signal Transduction;Site;Specificity;Structure;Substrate Specificity;Symbiosis;System;Systemic infection;Technology;Therapeutic;therapeutic target;Type III Secretion System Pathway;Typhoid Fever;Uncertainty;uptake;Vacuole;Vibrio;Virulence;Virulence Factors;Work;Yersinia

PROJECT_TITLE: Salmonella type III secretion: substrate targeting and injectisome assembly

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Immunization;Infectious Diseases;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Vaccine Related;Women's Health Research

PHR: Although there have been over 250,000 pregnant women with SARS CoV-2, there are limited data on rates of in utero transmission of SARS-CoV-2 due to diagnostic challenges. The overall goal of this study is to identify newborns with in utero SARS-CoV-2 infection and investigate clinical, virologic, and immunologic factors that may contribute to MTCT and neonatal immune and clinical outcomes. We plan a comprehensive algorithm to screen newborns for in utero SARS-CoV-2 and will determine if there are immunologic dysfunctions impacting clinical, neurodevelopmental, neurologic, and other abnormalities that may require long-term follow-up, treatments and/or interventions.

PI_NAMEs: KOVACS, ANDREA A.Z. (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 2019-nCoV;Algorithms;anti-IgA;anti-IgM;Antibodies;antibody detection;Biological Assay;Biological Markers;Birth;Blood specimen;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cellular Immunity;Clinical;Color;congenital infection;COVID-19 detection;COVID-19 screening;COVID-19 vaccine;Data;Development;Diagnostic;Disease;Evaluation;exhaustion;Feces;fetal;Flow Cytometry;Functional disorder;Goals;Hospitals;Hour;Humoral Immunities;Hybrids;IL8 gene;Immune;immune activation;Immune response;Immune System Diseases;Immunity;Immunoglobulin A;Immunoglobulin G;Immunoglobulin M;Immunohistochemistry;Immunologic Factors;Immunologics;in utero;Infant;Infant Development;infant infection;infant outcome;Infection;Inflammation;inflammatory marker;Interferon Type II;Interleukin-1 beta;Interleukin-15;Interleukin-6;Intervention;Life;Longterm Follow-up;maternal vaccination;Maternal-Fetal Transmission;Measures;Meconium;Morbidity - disease rate;mortality;Mothers;Multivariate Analysis;Neonatal;neonatal infection;Neonatal Screening;neurodevelopment;Neurologic;Neuropsychology;Newborn Infant;Oral;Outcome;Pathogenesis;Pathology;Placenta;placental infection;Pregnancy;Pregnant Women;prospective;Protocols documentation;Public Health;Recording of previous events;Reporting;Sampling;SARS-CoV-2 antibody;SARS-CoV-2 infection;SARS-CoV-2 infection history;SARS-CoV-2 transmission;screening;senescence;Stains;Standardization;stool sample;T cell response;T-Cell Activation;T-Lymphocyte;Testing;Time;TNF gene;Umbilical Cord Blood;Vaccination;Variant;Viral Load result;viral RNA;Whole Blood;Work

PROJECT_TITLE: Pathogenesis and Outcomes of SARS-CoV-2 In Utero Transmission - Immunologic and Virologic Evaluations

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Infectious Diseases;Rare Diseases;Sexually Transmitted Infections

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE  Syphilis affects millions of people worldwide, and its global rates are on the rise. Syphilis causative agent, Treponema pallidum (T. pallidum), can cause severe neurological sequelae, and individuals with syphilis are at higher risk of transmitting and acquiring HIV. Applying our newly developed genetic engineering approach to the syphilis agent will provide us with a better understanding of syphilis pathogenesis and pathogen persistence, and help devise new methods to control this serious infection.

PI_NAMEs: GIACANI, LORENZO  (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Acetates;Adopted;Adult;Affect;Animals;Antibiotics;Antigen Targeting;Antigenic Variation;Antigens;Aorta;arm;Attenuated;Biopsy;Cardiovascular Manifestation;Cause of Death;Cell Culture Techniques;Cessation of life;Communities;Comparative Study;congenital infection;Congenital Syphilis;Data;Dementia;design;Disease;DNA cassette;Engineering;Enzymes;Event;Fetal Death;Future;Gene Conversion;Gene Modified;Gene Silencing;Genes;Genetic Crossing Over;Genetic Engineering;genetic manipulation;Genetic Recombination;Genetic Transcription;global health;Goals;helicase;high risk;HIV;homologous recombination;Immune;Immune Evasion;Immune response;Immunity;Immunocompetent;immunosuppressed;improved;In Vitro;in vivo;Income;Individual;Infant Mortality;Infection;Injections;innovation;Kanamycin A;Kanamycin Resistance;Knock-out;Knowledge;Lesion;low and middle-income countries;lymph nodes;Manuscripts;Mediating;Methods;Methylprednisolone;Molecular;mutant;Mutation;Neurologic;novel;Oryctolagus cuniculus;Paralysed;pathogen;Pathogenesis;pathogenic bacteria;Patients;Persons;Phenotype;Population;Pregnancy;Proliferating;promoter;Proteomics;Publishing;Reporting;Research;response;Role;Site;stroke-like outcome;success;suicide vector;Surface;Syphilis;System;Testing;Time;transmission process;Treponema pallidum;Treponema pallidum subspecies pallidum;Uncertainty;United States;vaccine development;Variant;Virulence Factors;Writing

PROJECT_TITLE: Investigating Syphilis Pathogenesis Through Genetic Engineering of Treponema pallidum


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: The nervous system has the remarkable ability to sustain its function over lifetime of an organism. The goals of this research program are to advance our knowledge of how axons and synapses are formed and maintained, and the proposed experiments will identify new mechanisms underlying dynamic cellular processes that ensure function of neural circuits. The findings will offer fundamental insights into how genetic mutations and environmental insults cause dys-regulation of neural circuits, leading to neurological disorders.

PI_NAMEs: JIN, YISHI  (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Adolescent;Adult;Animal Model;Animals;Axon;axon injury;axon regeneration;biological adaptation to stress;Brain;Caenorhabditis elegans;Calcium;Cell Physiology;Coupled;Development;Dissection;DNA Sequence Alteration;Ensure;Event;experimental study;Functional disorder;gene discovery;Genetic Models;Genetic Screening;Goals;Growth;holistic approach;Homologous Gene;Human;in vivo evaluation;in vivo imaging;innovative technologies;insight;interest;Knowledge;Maintenance;Membrane;molecular dynamics;Molecular Genetics;Motor;Mus;Nerve Degeneration;Nervous System;Nervous System Disorder;neural circuit;Neurons;Neurophysiology - biologic function;Organelles;Organism;Pathologic Processes;Pathway interactions;Pattern;Phase;Physiological;Play;Process;programs;Property;Proteins;regeneration model;Repression;Research;Resolution;Role;Signal Transduction;single-cell RNA sequencing;Stereotyping;Subcellular structure;Synapses;synaptogenesis;Transcriptional Regulation;Visualization

PROJECT_TITLE: Molecular genetics of axon and synapse development and maintenance


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Rare Diseases;Vector-Borne Diseases

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative Mosquitoes infect hundreds of millions of people with deadly pathogens every year. Since mosquitoes rely heavily on their sense of smell to find and bite humans, one promising strategy to control such pathogens is the deployment of repellant and attractive odor blends that push mosquitoes away from humans or pull them into lethal traps. Our research will provide a transformative inroad into the rational design of such blends by mapping individual odor-sensing neurons on mosquito antennae to the molecular receptors they express and the human odorants they detect.

PI_NAMEs: MCBRIDE, CAROLYN SARAH (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Administrative Supplement;Aedes;Arboviruses;Area;Bite;cell type;Chemicals;cost;CRISPR/Cas technology;Culicidae;Dengue;Detection;Female;Funding;Gene Library;Genetic;genome editing;Goals;Human;Human Bites;Individual;Ligands;Maps;Maxilla;Microscope;microscopic imaging;Molecular;neuroimaging;Neurons;Odors;Olfactory Pathways;olfactory receptor;parent project;pathogen;Persons;Property;Publications;rational design;receptor;repaired;Research;Resources;response;single nucleus RNA-sequencing;Smell Perception;tool;two-photon;vector control;vector mosquito;Volatilization;Work;Yellow Fever;ZIKA

PROJECT_TITLE: Molecular and functional characterization of olfactory pathways in the arbovirus vector mosquito Aedes aegypti


NIH_SPENDING_CATS: Genetics;Immunotherapy

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE The long-term goal of the proposed research is to understand how cells acquire the capacity to elicit specific responses to environmental cues. We aim to define the mechanistic roles of a novel chromatin remodeling complex in equipping T cells early in development with the potential to kill, secrete cytokines, and promote other T cell-specific functions. Understanding these fundamental processes will allow the modulation of T cell effector programming which can enhance vaccination, cancer immunotherapy and ameliorate autoimmunity.

PI_NAMEs: KOH, ANDREW S (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Achievement;ATP phosphohydrolase;Autoimmunity;base;Biological Models;Biological Process;cancer immunotherapy;Cell Physiology;Cells;Cellular biology;Chromatin;Chromatin Remodeling Factor;clinical application;Complex;Cues;cytokine;Decision Making;Development;effector T cell;experimental study;Foundations;Genes;Genome;Goals;Growth;human DNA;interest;Laboratories;Mediating;Molecular;Molecular Conformation;Motor;novel;Nuclear;Nucleosomes;Process;programs;receptor;Regulation;Research;response;Role;Seminal;Signal Pathway;Stimulus;T-Cell Receptor;T-Lymphocyte;transcription factor;Vaccination

PROJECT_TITLE: Epigenesis of Cell Fate Potential

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PI_NAMEs: SENA, ARLENE  (contact)

PROJECT_TERMS: Clinical Research;diagnostic development;Diagnostics Research;Performance;Resources;sample collection;Syphilis

PROJECT_TITLE: Syphilis Specimen Collection


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Obesity;Patient Safety;Prevention;Women's Health Research

ORG_NAME: EMORY UNIVERSITY

PI_NAMEs: CWIAK, CARRIE  (contact)

PROJECT_TERMS: Clinical Trials Network;Conduct Clinical Trials;Contraceptive Agents;Contraceptive methods;Development;Female Contraceptive Agents;Future;Goals;Medical;Methods;Mission;National Institute of Child Health and Human Development;Obesity;product development;Program Development;protocol development;Protocols documentation;Risk Reduction;Services;Site;unintended pregnancy;venous thromboembolism;Woman

PROJECT_TITLE: CCTN-CONTRACEPTIVE DEVELOPMENT PROGRAM – CORE FUNCTION ACTIVITIES FOR SITES OF FEMALE CONTRACEPTIVE STUDIES - EMORY


NIH_SPENDING_CATS: Contraception/Reproduction;Obesity;Patient Safety;Prevention;Women's Health Research

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PI_NAMEs: EDLMAN, ALISON  (contact)

PROJECT_TERMS: Clinical Trials Network;Conduct Clinical Trials;Contraceptive Agents;Contraceptive methods;Development;Female Contraceptive Agents;Future;Goals;Medical;Methods;Mission;National Institute of Child Health and Human Development;Obesity;Oregon;product development;Program Development;protocol development;Protocols documentation;Risk Reduction;Services;Site;unintended pregnancy;venous thromboembolism;Woman

PROJECT_TITLE: CCTN-CONTRACEPTIVE DEVELOPMENT PROGRAM – CORE FUNCTION ACTIVITIES FOR SITES OF FEMALE CONTRACEPTIVE STUDIES - OREGON


ORG_CITY: MENANDS

ORG_NAME: NYSDOH/HEALTH RESEARCH, INC.

PI_NAMEs: MICHELE, CAGGANA  (contact)

PROJECT_TERMS: Advisory Committees;Affect;American;Annual Reports;Authorization documentation;Biological Assay;Cessation of life;Child;Child Health;Clinical;Clinical Treatment;Collaborations;Contractor;Contracts;Development;Developmental Disabilities;Disabling condition;Disease;Early Diagnosis;Early treatment;Evaluation;Goals;Hereditary Disease;Intellectual functioning disability;Laboratories;Left;Medical Genetics;medical schools;meetings;member;National Institute of Child Health and Human Development;Neonatal Screening;Nervous System Trauma;new technology;Newborn Infant;physically handicapped;Pilot Projects;programs;Published Comment;Rare Diseases;Recommendation;Reporting;Schedule;screening guidelines;screening panel;Severities

PROJECT_TITLE: NEWBORN SCREENING PILOT STUDIES - CORE FUNCTION ACTIVITIES


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: MALVERN

ORG_NAME: VENATORX PHARMACEUTICALS, INC.

ORG_STATE: PA

PI_NAMEs: PEVEAR, DANIEL  (contact)

PROJECT_TERMS: Advanced Development;Bacterial Antibiotic Resistance;Bacterial Drug Resistance;bacterial resistance;biodefense;candidate selection;Chemistry;Clinical assessments;Combating Antibiotic Resistant Bacteria;efficacy evaluation;Emerging Communicable Diseases;lead optimization;manufacture;pathogen;pre-clinical;product development;research and development;Research Support;safety assessment;Therapeutic;therapeutic candidate;therapeutic development

PROJECT_TITLE: Development of Therapeutic Products for Antibiotic Resistant Bacteria


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PI_NAMEs: BURKE, M.D., MPH, ANNE  (contact)

PROJECT_TITLE: CCTN-CONTRACEPTIVE DEVELOPMENT PROGRAM – CORE FUNCTION ACTIVITIES FOR SITES OF FEMALE CONTRACEPTIVE STUDIES - JHU


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative Enhanced antioxidant capacity in cancer cells is an important contributor to the malignancy, metastatic potential and lethality of tumors. Antioxidants display heterogenous distribution among subcellular compartments, through its involvement in cancer progression and metastasis remains poorly understood. Using mitochondrial glutathione as a model, this proposal seeks to determine its role in metastasis, decipher its sensing mechanism and develop new tools to profile its distribution in the tumor microenvironment at the single-cell resolution.

PI_NAMEs: LIU, YUYANG  (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: activity-based protein profiling;Animal Model;Antioxidants;Binding;Biochemical;Biological Process;Biomass;Breast Cancer cell line;breast cancer metastasis;cancer cell;Cancer Model;Cancerous;Cell Survival;cell type;Cells;CRISPR screen;Cytosol;detection of nutrient;Engineering;Ensure;Enzymes;Epitopes;Eukaryotic Cell;Feedback;Gene Expression;Glutathione;Glutathione Metabolism Pathway;Growth;Heterogeneity;Homeostasis;Immune system;Immunoprecipitation;Immunotherapy;insight;Iron;Knock-out;Label;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Messenger RNA;Metabolic;Metabolic stress;Metabolism;Metastatic breast cancer;Mitochondria;Modeling;Mus;mutant;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;Nutrient;Organelles;Oxidation-Reduction;Paint;Pathologic;Pathway interactions;Peptide Hydrolases;Phase;Physiological;Play;Post-Translational Regulation;posttranscriptional;prevent;Process;Proteins;Proteolysis;prototype;Publishing;Radioactive;Reduced Glutathione;Refuse Disposal;Regulation;Reporter;Resolution;response;Role;single cell sequencing;single-cell RNA sequencing;Stress;Sulfur;Testing;tool;tumor;tumor heterogeneity;tumor microenvironment;tumor progression;Tumor stage;uptake;Work

PROJECT_TITLE: Dissecting the role of mitochondrial glutathione homeostasis in cancer


ORG_CITY: MINNEAPOLIS

ORG_NAME: MINNEAPOLIS VA  MEDICAL CENTER

ORG_STATE: MN

PHR: Cognitive aging is the decline in performance with age seen in otherwise healthy people free of even of asymptomatic degenerative brain disease. The anterior cingulate cortex (ACC) appears to be the principal site of hypometabolism in cognitive aging; this decline correlates with declining executive function. A hypothesis posits ACC dysfunction is related to oxidative stress that is seen universally in models of aging. Furthermore, emotional stress can contribute to oxidation thereby aggravating ACC hypometabolism. This project tests whether aging and emotional stress, the latter as indexed by PTSD, is associated with redox stress in the ACC. If demonstrated and quantified, use of antioxidants such as nicotinamide riboside or N-acetyl cysteine will be motivated to treat and prevent this aging-related cognitive decline.

PI_NAMEs: PARDO, JOSE V (contact)

PROJECT_TERMS: Accounting;Adenine;Adult;Aerobic Exercise;aerobic glycolysis;Age;age acceleration;age related decline;Age-associated memory impairment;Aging;aging brain;aging related;Alzheimer's Disease;American;Amyloid;Anterior;antioxidant therapy;Antioxidants;Apoptosis;Area;Atrophic;Attention;baby boomer;Behavior Disorders;Biochemical Pathway;Biological Markers;Biology;Brain;Brain Diseases;Buffers;Cell Aging;Cell Respiration;Chronic;Chronic Post Traumatic Stress Disorder;cingulate cortex;Clinical;Clinical Trials;cofactor;Cognition;Cognition Disorders;Cognitive;Cognitive aging;cognitive change;Cognitive deficits;cognitive reserve;combat;Cysteine;Data;Deposition;Development;Diet;Dinucleoside Phosphates;Discipline;Disease;DNA Damage;DNA Methylation;DNA Repair;Drug Metabolic Detoxication;Economics;Elderly;Emotional Stress;endophenotype;Environment;epigenetic marker;executive function;Exposure to;Functional disorder;Future;Generations;Gluconeogenesis;glucose metabolism;Glutathione;Health;Health behavior;Human;human old age (65+);Impaired cognition;Impairment;in vivo;indexing;Inflammation;Infrastructure;interest;Intervention;ketogenesis;Laboratories;lipid biosynthesis;Lipids;Magnetic Resonance;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measures;medial temporal lobe;Mediating;Medical;Memory;Memory impairment;Mental disorders;Metabolic;Metabolic dysfunction;Metabolism;Methods;mitochondrial dysfunction;Modeling;NADH;NADP;Nerve Degeneration;Neurodegenerative Disorders;neuronal excitability;Neuropsychological Tests;nicotinamide-beta-riboside;Nicotine;nicotine use;novel;novel diagnostics;Occipital lobe;Outcome;Oxidants;oxidation;Oxidation-Reduction;Oxidative Phosphorylation;Oxidative Stress;Pathologic;pathological aging;Pathway interactions;Patients;Pellagra;Performance;Persons;Pharmacologic Substance;Plasma;Play;Post-Traumatic Stress Disorders;pre-clinical;prevent;Prevention;Prevention strategy;Proteins;Psyche structure;Quality of life;Reactive Oxygen Species;Regulation;rehabilitation strategy;Research;Research Priority;response;Risk Factors;Role;Secondary Prevention;Severities;Signal Transduction;Sirtuins;Site;Stress;stress disorder;stress management;Symptoms;System;tau Proteins;Telomere Shortening;Testing;Therapeutic;therapeutic target;Trauma;Universities;verbal;Veterans;Visit;Work;young adult

PROJECT_TITLE: Aging, PTSD, and the Anterior Cingulate Cortex (ACC)


ORG_CITY: MATHER

ORG_NAME: VA NORTHERN CALIFORNIA HEALTH CARE SYS

ORG_STATE: CA

PHR: The burden of COVID-19 on survivors and health care systems is greater than we imagined. Most Veterans recover from the illness, but a considerable number have lingering symptoms that affect mental health and sleep. Cognitive problems are commonly reported in post-acute COVID-19, with a substantial impact on social and occupational function. Yet self-reported “brain fog” appears to be an under- investigated outcome. A distinct gap in the literature to date is objective cognitive testing in Veterans who had a positive test for COVID-19. The current project will use a web-based platform to directly assess cognitive function over time and its relationship to mental health in COVID survivors. Determining which factors are most associated with the negative consequences of compromised cognitive function post- COVID is a critical question not yet addressed by current studies. The results will have important implications for Veterans and the VA, especially since new variants of the virus will appear in the future.

PI_NAMEs: SWICK, DIANE  (contact)

PROJECT_TERMS: 2019-nCoV;Address;Affect;Anxiety;Anxiety Disorders;associated symptom;brain fog;breakthrough infection;Cardiovascular system;Caring;Cognitive;cognitive function;cognitive performance;cognitive testing;Commerce;Communities;comorbidity;comparison control;comparison group;COVID-19;COVID-19 burden;COVID-19 diagnosis;COVID-19 impact;COVID-19 pandemic;COVID-19 patient;COVID-19 survivors;COVID-19 test;daily functioning;design;Development;Diabetes Mellitus;Diagnosis;Disease;Education;Employment;epidemiology study;Episodic memory;executive function;Fatigue;follow-up;Follow-Up Studies;Future;Health;Healthcare Systems;Heart Diseases;Hypertension;Impaired cognition;Impairment;improved;Individual;Infection;Intervention;Investigation;Literature;Long COVID;long term consequences of COVID-19;Measures;Mental Depression;Mental Health;Metabolic Diseases;military veteran;Minority;Modeling;Monitor;neurocognitive disorder;Observational Study;Occupational;Online Systems;Outcome;Outcome Measure;pandemic disease;Participant;Patient Self-Report;Patients;Performance;persistent symptom;Persons;Phase;physical symptom;Population;Post-Acute Sequelae of SARS-CoV-2 Infection;post-COVID conditions;post-COVID-19;Post-Traumatic Stress Disorders;Printing;Process;prospective;Psyche structure;Quality of life;Recording of previous events;Reporting;Resistance;respiratory;Risk;SARS-CoV-2 B.1.1.529;SARS-CoV-2 infection;SARS-CoV-2 negative;SARS-CoV-2 positive;selective attention;Services;Severe Acute Respiratory Syndrome;Short-Term Memory;Sleep;Sleeplessness;social;social relationships;Societies;Surveys;Survivors;sustained attention;Symptoms;System;Testing;Time;Trauma;trend;unvaccinated;Vaccines;Variant;Veterans;Virus;web platform;Work

PROJECT_TITLE: Long-Term Effects of COVID-19 on Cognitive Function and Mental Health


NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision

ORG_CITY: BOSTON

ORG_NAME: SCHEPENS EYE RESEARCH INSTITUTE

PHR: No PHR

PI_NAMEs: KEMPEN, JOHN H;LUO, GANG  (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Africa;Caring;Cellular Phone;Vision

PROJECT_TITLE: Overcome the barriers of vision care in Africa using smartphones


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE The hippocampus is the central brain structure without which we could not navigate our environment or remember recent events. The hippocampal synaptic circuits that mediate information transfer and contribute to the storage and retrieval of memories are therefore crucial to our understanding of memory deficits associated with aging and neurological disorders such as Alzheimer’s disease. In this project we will dissect the mechanisms that contribute to plasticity of a hippocampal synapse and determine how this contributes to specific forms of episodic memory.

PI_NAMEs: CONTRACTOR, ANIS  (contact);SAVAS, JEFFREY NICHOLAS

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: 2'-adenylic acid;Affect;Aging;Alzheimer's Disease;Anatomy;Animals;Anxiety Disorders;Behavioral;Biochemical;Brain;Chemosensitization;Coupling;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Dense Core Vesicle;dentate gyrus;Electrophysiology (science);Environment;Episodic memory;Event;Exocytosis;experience;Goals;Heart;hippocampal pyramidal neuron;Hippocampus;Impairment;In Situ;In Vitro;insight;Knock-out;Label;Learning;Mammals;Mediating;member;Memory;Memory impairment;memory process;memory retrieval;Microscopy;Molecular;mossy fiber;Mus;nanoenvironment;Nervous System Disorder;neural circuit;Neurodegenerative Disorders;Neurons;Neuropeptides;neuropsychiatric disorder;neurotransmitter release;Pattern;pharmacologic;Phosphorylation;Physiological;Physiology;Play;postsynaptic;presynaptic;Process;Protein Kinase Protein Phosphorylation;Proteins;Proteomics;Research;Resolution;Retrieval;Role;Schizophrenia;Signal Pathway;Signal Transduction;social;Structure;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;Synaptic Vesicles;Testing;Vesicle;Visit;way finding

PROJECT_TITLE: Effectors of presynaptic cAMP dependent potentiation at mossy fiber synapses

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Infant Mortality;Lung;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: PROJECT NARRATIVE Tetralogy of Fallot (TOF) is a critical congenital heart disease that affects about 1 in 2520 babies born in the US each year, and frequently requires lifesaving surgery within the first year of life and valve replacement. Due to the characteristic blood flow dynamics in TOF, fetal semilunar heart valves and their supporting structures are susceptible to flow-induced prenatal pathophysiological remodeling that alters deposition of important constituents (such as collagen and elastin) in valve leaflets, impacting their competence. Using in vivo echocardiography and correlative multiscale imaging, as well as computational and mathematical modeling, this project will establish predictive relationships between abnormal blood flow in fetal TOF and detrimental remodeling of valves, ultimately guiding lifesaving treatment strategies for babies with TOF.

PI_NAMEs: RUGONYI, SANDRA  (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: 3-Dimensional;Address;Affect;Aorta;Arteries;Birds;Birth;Blood;Blood flow;Cardiac;Cell Differentiation process;Cells;Characteristics;Chemicals;Chick;Chick Embryo;Collagen;Collagen Fiber;Competence;Computer Models;Confocal Microscopy;Congenital atresia of pulmonary valve;congenital heart abnormality;Critical Congenital Heart Defects;critical congenital heart disease;Cues;Data;Deposition;Development;Diameter;Echocardiography;Elastin;Elastin Fiber;Embryo;Event;Exhibits;experience;Extracellular Matrix;Face;fetal;Fetal Development;fetal diagnosis;Fetal Heart;Fetus;Functional disorder;Future;hatching;Heart;heart function;heart imaging;Heart Valves;hemodynamics;Human;Image;imaging modality;Impairment;improved;in vivo;in vivo imaging;Intervention;Knowledge;Left ventricular structure;Life;light microscopy;Longitudinal Studies;Lung;Maps;mathematical model;microCT;Microscopy;Modeling;Morphology;Natural regeneration;Newborn Infant;novel;Operative Surgical Procedures;Organ;Pathologic;Pattern;predictive modeling;Predisposition;prenatal;Process;Pulmonary artery structure;Pulmonary Valve Stenosis;Resolution;response;Right ventricular structure;Scanning Electron Microscopy;semilunar valve;shear stress;Side;Smooth Muscle Myocytes;Structure;Surface;Testing;Tetralogy of Fallot;Time;Tissues;treatment strategy;valve replacement;Ventricular Septal Defects

PROJECT_TITLE: Prenatal valve formation in congenital heart disease

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Achieving Maternal Equity and Transforming Health through Implementation Science and Training (AMETHIST@Penn) The Achieving Maternal Equity and Transforming Health through Implementation Science and Training (AMETHIST@Penn) Hub will support the vision of the NIH IMPROVE initiative by providing consultation and technical assistance to Maternal Health Research Centers of Excellence and other IMPROVE investigators. The AMETHIST@Penn team will work closely with NIH staff and the Data Innovation and Coordinating Hub/Resource Center and will support equity-focused maternal health implementation research through five Cores: (1) Administration, Leadership, and Evaluation; (2) Equity, Community, and Stakeholder Engagement; (3) Design, Methods, and Analysis; (4) Policy, Dissemination, and Communication; and (5) Training and Capacity Building. AMETHIST@Penn will serve IMPROVE investigators by advising them in engaging diverse and sometimes marginalized communities; guiding the process of implementation research including the selection of theories, models, frameworks, strategies, and outcomes; and accelerating implementation skills development in emerging and established maternal health scientists.

PI_NAMEs: HAMM, REBECCA FELDMAN;LANE-FALL, MEGHAN BROOKS (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Acceleration;Accountability;acute care;Address;advanced analytics;Centers of Research Excellence;Clinical;Communication;Communities;community partners;Consultations;Data;data integration;design;Discipline of obstetrics;Disparity;Equity;Evaluation;experience;falls;Health;health disparity populations;health economics;implementation outcomes;implementation research;implementation science;improved;innovation;Institution;International;Leadership;Maps;marginalized community;marginalized population;Maternal Health;Maternal health equity;Maternal Mortality;Maternal-fetal medicine;Mentors;Methods;Modeling;Outcome;Patients;Pennsylvania;Perinatal Care;Policies;postpartum care;Pregnancy Outcome;Prenatal care;Procedures;Process;programs;prospective;Public Health;Research;Research Methodology;Research Personnel;Resources;Scientist;skill acquisition;skills;Source;Specialist;success;theories;Training;Training Programs;United States National Institutes of Health;Universities;Vision;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(70)-R]


ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative Mitochondrial calcium transport proteins regulate important physiological functions, including cell bioenergetics, cytoplasmic calcium signaling, and the initiation of cell death. This project will determine their molecular mechanisms and the mechanisms by which small-molecule compounds modulate their activities. The results will advance our molecular understanding of the physiologically crucial mitochondrial calcium transport process, and can provide key information to facilitate the development of new medicines to treat diseases related to abnormal mitochondrial calcium homeostasis.

PI_NAMEs: TSAI, MING-FENG  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: antiport;Back;Biochemical;Bioenergetics;Biophysics;Calcium;Calcium Signaling;calcium uniporter;Carrier Proteins;Cell Death;Cells;CLC Gene;Complex;Cysteine;Cytoplasm;design;Development;Disease;Electrophysiology (science);Future;Goals;Heart failure;Homeostasis;improved;Inner mitochondrial membrane;innovation;Ion Transport;Kinetics;Knowledge;Liposomes;Mediating;Medicine;member;Methods;Mitochondria;Mitochondrial Matrix;Molecular;Neoplasm Metastasis;Neurodegenerative Disorders;Neurons;novel;novel therapeutic intervention;oxidation;Oxidative Phosphorylation;Pathologic;Pathway interactions;pharmacologic;Physiological;Property;Proteins;reconstitution;Regulation;Reperfusion Injury;Research;Role;Side;Signal Transduction;small molecule;structural biology;System;Testing;tool;Transport Process;Work

PROJECT_TITLE: Molecular mechanisms of the mitochondrial calcium transport system

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: PROJECT NARRATIVE Therapeutic interventions, such as exposure therapy, reduce pathological fear in patients with anxiety disorders—but this fear reduction is often transient and vulnerable to relapse. Stress undermines exposure therapy by disabling brain circuits critical for extinction learning. The long-term goal of this project is to understand the circuit and cellular mechanisms by which stress undermines extinction learning, a program of study that is essential for improving the long-term efficacy of exposure-based therapies .

PI_NAMEs: MAREN, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TITLE: Neural Circuits for Stress-Impaired Extinction Learning

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: This project will evaluate whether a novel influenza vaccine antigen elicits broadly cross-reactive T cell responses in cattle and ferrets, and protects ferrets against challenge with the avian influenza (H5N1) virus that is currently infecting and spreading among cows in the US. These studies have implications in the development of an effective avian influenza vaccine for animals and humans.

PI_NAMEs: KLEIN, BRUCE STEVEN;SURESH, MARULASIDDAPPA  (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Adjuvant;Administrative Supplement;Affect;Agonist;Animals;Antibodies;Avian Influenza;Avian Influenza A Virus;Bird Flu vaccine;Cattle;Circulation;Clinical;COVID-19 pandemic;cross reactivity;Dairying;design;Development;Disease;Disease Outbreaks;Domestic Fowls;Epidemic;Epitopes;Exhibits;Felis catus;Ferrets;Human;Immunity;immunogenic;Influenza A virus;Influenza A Virus, H5N1 Subtype;influenza infection;influenza virus vaccine;influenzavirus;Lipid A;Lung;Mammary gland;mosaic;Mus;Mutate;novel;Nucleoproteins;Outcome;pandemic influenza;pathogenic fungus;pathogenic virus;programs;respiratory;Severity of illness;swine influenza;T cell response;Testing;transmission process;Upper respiratory tract;Vaccine Antigen;vaccine development;vaccine formulation;vaccine strategy;Vaccines;Viral Proteins;viral transmission;Virus

PROJECT_TITLE: Combination Adjuvants to Program Durable Immunity to Respiratory Viral and Fungal Pathogens


NIH_SPENDING_CATS: Genetics

ORG_CITY: Columbus

ORG_DEPT: GENETICS

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative tRNAs are essential for decoding the genome and regulating the proteome in response to nutrient availability and stress. We employ the powerful budding yeast model system and genetics/genomics, microscopy, molecular, and biochemical in vivo technologies to resolve key unknowns including tRNA nuclear/cytoplasmic bidirectional trafficking, quality control, and intron turnover/function. The requested Integra Mini 96-well channel pipette will facilitate genome-wide screens to discover importers/regulators of tRNA retrograde nuclear import and identify tRNA intron turnover machinery by allowing high throughput biochemical/molecular procedures to be conducted in the 96-well format.

PI_NAMEs: HOPPER, ANITA K (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Adaptor Signaling Protein;Address;Affect;Amino Acids;Aniline;Apoptosis Regulation Gene;Archaea;Back;Biochemical;Biological;Biological Assay;Biological Process;Biology;Cell Nucleus;cell preparation;Cells;Code;Codon Nucleotides;Complex;crosslink;Cytoplasm;Data;Defect;Disease;Equilibrium;Equipment;Eukaryotic Cell;Explosion;Exportins;Family;Formaldehyde;Funding;Gel;gene conservation;Gene Expression;gene product;Genes;Genetic;Genetic study;Genetic Transcription;Genome;genome wide screen;Genomics;Growth;Health;Human;human disease;Importins;in vivo;Individual;Introns;Knowledge;Learning;Licensing;Malignant Neoplasms;Messenger RNA;Metabolic Diseases;Methodology;Microscopy;Modification;Molecular;Movement;mRNA Stability;mutant;Neuromuscular Diseases;novel;Nuclear;Nuclear Export;Nuclear Import;nuclease;Nutrient availability;Organism;overexpression;parent grant;Pathway interactions;Phenylalanine-Specific tRNA;Play;posttranscriptional;preference;Procedures;Process;programs;protein function;Proteins;Proteome;Quality Control;Regulation;Regulator Genes;Reporting;Research;response;Ribonucleases;Ribosomes;RNA;RNA Splicing;Role;Saccharomycetales;Safety;Signal Transduction;Specific qualifier value;Specificity;Stress;Stretching;Technology;Testing;Time;trafficking;Transfer RNA;Translating;translational engagement;Translational Regulation;Translations;Travel;tRNA Precursor;Untranslated RNA;Vertebrates;Work;Yeast Model System;Yeasts

PROJECT_TITLE: tRNA processing and nuclear-cytoplasmic dynamics

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Diabetes;Nutrition;Physical Activity;Prevention

ORG_CITY: BLACKSBURG

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

PHR: PROJECT NARRATIVE Low exercise capacity is one of the strongest predictors for the risk of chronic disease and mortality. However, improvements to exercise capacity in response to exercise training can be blunted in people and animal models with hyperglycemia; a condition that is becoming increasingly prevalent as rates of metabolic disease rise globally. This study will determine the cellular and molecular mechanisms for low response to exercise training associated with hyperglycemia, and test specific therapies to improve exercise capacity, which may ultimately lead to better health and increased lifespan.

PI_NAMEs: LESSARD, SARAH  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Aerobic;Aerobic Exercise;angiogenesis;animal data;Animal Model;Biological Markers;Blood Glucose;Breeding;cardiorespiratory fitness;Cardiovascular Diseases;Chronic;Chronic Disease;circulating biomarkers;Clinical;clinical investigation;Cultured Cells;Data;Development;Diabetes Mellitus;dietary;effective therapy;Endothelial Cells;endothelial stem cell;Event;Exercise;exercise capacity;exercise training;extend lifespan;Extracellular Matrix;genetic selection;Glucose;glucose metabolism;glucose tolerance;glycation;Goals;Health;healthspan;Human;human subject;Hyperglycemia;impaired glucose tolerance;Impairment;improved;In Vitro;Individual;Investigation;Knockout Mice;Link;Longevity;MAPK8 gene;Measures;mechanical signal;Mediator;Metabolic;Metabolic Diseases;metabolic rate;Metabolic syndrome;Methodology;Modeling;Modification;Molecular;mortality;mouse model;Muscle;Muscle Fibers;Muscle function;muscle progenitor cell;Non-Insulin-Dependent Diabetes Mellitus;novel;Oxygen Consumption;Persons;Phenotype;Physical activity;Physiological;Population;prevent;Prevention;Process;Proteins;Proteomics;Rattus;Research;Resistance;response;Risk;Risk Factors;Risk Marker;Risk Reduction;screening;Serum;Signal Transduction;Skeletal Muscle;Testing;tissue culture;Tissues;Training;translational approach;treatment strategy;type I and type II diabetes;virtual

PROJECT_TITLE: Mechanisms for Impaired Adaptation to Aerobic Exercise with Metabolic Disease

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Cancer;Clinical Research;Diabetes;Digestive Diseases;Pancreatic Cancer;Prevention;Rare Diseases

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PROJECT NARRATIVE Chronic pancreatitis is a painful and debilitating disease with few medical treatment options. Patients often require pancreatic surgery for relief of pain, but pancreatic surgery may increase the risk for blood glucose abnormalities and diabetes mellitus. At the University of Minnesota, we will enroll patients in multiple clinical research studies in the Chronic Pancreatitis Diabetes Pancreatic Cancer (CPDPC) Consortium and will develop new clinical studies that better define how different pancreatic surgeries impact diabetes risk.

PI_NAMEs: BEILMAN, GREGORY J;BELLIN, MELENA D. (contact);TRIKUDANATHAN, GURU V

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: acute pancreatitis;Adult;Anatomy;Ancillary Study;anti-cancer research;Autoantibodies;Autologous Transplantation;Beta Cell;Biological Markers;Blood Glucose;Cell Death;Child;chronic pancreatitis;Clinical;clinical care;clinical center;Clinical Research;Collaborations;Complex;Control Groups;Defect;Development;Diabetes Mellitus;diabetes risk;Disease;Drainage procedure;Endocrine;Enrollment;Environment;Functional disorder;genetic risk factor;Glucose;Goals;Hormone secretion;Hyperglycemia;Hypoglycemia;incretin hormone;innovation;Insulin;insulin sensitivity;Intestines;intravenous glucose tolerance test;islet;Lead;Malignant neoplasm of pancreas;Manuscripts;Medical;Minnesota;non-diabetic;novel;Ohio;Operative Surgical Procedures;Pain;pain relief;Pancreas;Pancreatectomy;Pancreatic Diseases;Pancreatic Hormones;Pancreaticoduodenectomy;Pancreatitis;participant enrollment;Patient Care;patient subsets;Patients;Polypeptide Hormones;prevent;Procedures;protocol development;Protocols documentation;Regulation;Research Personnel;research study;Risk;Risk Factors;Sampling;Series;Structure;Surgical Management;Testing;Total Pancreatectomy;Universities;working group

PROJECT_TITLE: University of Minnesota Clinical Center for the Study of Pancreatic Disease