NIH_SPENDING_CATS: Biotechnology;Complementary and Integrative Health;Dietary Supplements;Kidney Disease;Microbiome;Nutrition;Prevention;Rare Diseases;Urologic Diseases

ORG_CITY: LARAMIE

ORG_NAME: UNLOCKED LABS INC.

ORG_STATE: WY

PHR: Project Narrative Our long-term goal is to advance the development and market deployment of a probiotic Bacillus subtilis strain called OX164, which has an optimized ability to biodegrade oxalic acid. The ultimate goal is to develop a novel and innovative tool to prevent kidney stones that is not only cost-effective and widely accessible but also inherently safe. Our promising SBIR Phase I results, the societal need for new, innovative and improved kidney stone prevention tools, and the commercial potential strongly justify our proposed SBIR Phase II project.

PI_NAMEs: GEISLER, CHRISTOPH  (contact)

PROGRAM_OFFICER_NAME: CONAGE-POUGH, JASON EDWARD

PROJECT_TERMS: absorption;Address;adherence rate;Advanced Development;Adverse effects;Animals;Bacillus subtilis;Bacteriology;Birds;Calcium Oxalate;Cells;Clinical Trials;commercialization;cost;cost effective;Data;design;Development;Diet;Diet Modification;dietary;Distress;dosage;Dryness;economic impact;Enzymes;Evaluation;Excretory function;Food;Gastrointestinal tract structure;Genetic;Goals;Government;Growth;gut microbiome;Health;Human;Hyperoxaluria;Hypokalemia;improved;In Vitro;in vivo;innovation;insight;Intake;Journals;Kidney;Kidney Calculi;Legal patent;Letters;Life;Liquid substance;manufacturing scale-up;Manuscripts;Marketing;Medical;Metabolism;microCT;Modeling;No-Observed-Adverse-Effect Level;novel;overexpression;Oxalates;Oxalic Acids;Pain;Peer Review;Personal Satisfaction;Persons;Phase;potassium citrate;Prevalence;prevent;Prevention;Prevention approach;Probiotics;Process;psychological distress;Publications;Publishing;Qualifying;Rattus;Recommendation;Recurrence;Reproducibility;Research;research and development;Running;Safety;scale up;side effect;Small Business Innovation Research Grant;Small Intestines;Source;stability testing;Standardization;Stomach;Testing;Thiazide Diuretics;Thinness;tool;Toxicology;urinary;Urine;Urology;X-Ray Computed Tomography

PROJECT_TITLE: Oxalate Biodegrading Probiotic for Kidney Stone Prevention

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-R (11)]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Immunization;Immunotherapy;Orphan Drug;Rare Diseases

ORG_CITY: REDWOOD CITY

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: ELIXERA, INC.

ORG_STATE: CA

PHR: Project Narrative: Acromegaly is a rare but potentially lethal disorder of the endocrine system caused by a benign tumor in the pituitary gland that produces excess growth hormone. There is an unmet medical need for drug treatment that can control the growth hormone to within normal levels consistently across the patient population. Elixera has discovered and developed a novel antibody therapeutic for treatment of acromegaly that will be validated in preclinical models before beginning clinical testing.

PI_NAMEs: ZANGHI, ADIBA  (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Acromegaly;Adult;Affect;Affinity;antagonist;Antibody Therapy;Benign;Binding;Biological;Biological Assay;Cardiovascular Diseases;Cell Line;Cells;Chronic;clinical development;Clinical Trials;commercialization;comorbidity;Complex;Consensus;Data;Development;Diagnosis;Disease;Dose;Drug Kinetics;effective therapy;Emerging Technologies;Endocrine system;Endocrine System Diseases;Engineering;Epitope Mapping;experimental study;Fc domain;first-in-human;Funding;Generations;Genetic;Genetic Engineering;Goals;Grant;Growth Hormone Receptor;Health;Hormone secretion;Hormones;human monoclonal antibodies;immunogenicity;Impairment;improved;In Vitro;in vivo;innovation;Insulin-Like Growth Factor I;Intellectual Property;Investments;lead candidate;Left;Life Expectancy;lipid metabolism;manufacturability;manufacture;Marketing;Medical;Metabolic Diseases;Modeling;Monoclonal Antibodies;mortality;Mus;Non-Insulin-Dependent Diabetes Mellitus;nonhuman primate;novel;novel therapeutics;Operative Surgical Procedures;patient population;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phase;Pituitary Diseases;Pituitary Gland;Pituitary Gland Adenoma;Pituitary Neoplasms;Point Mutation;Positioning Attribute;pre-clinical;Pre-Clinical Model;Production;Radiation;Recombinants;research clinical testing;Respiration Disorders;Small Business Innovation Research Grant;somatostatin analog;Somatotrophin increased;Somatotropin;Somavert;synergism;Technology;Testing;Therapeutic;Therapeutic antibodies;therapeutic candidate;Tissues;Toxicology;tumor;United States National Institutes of Health;Work

PROJECT_TITLE: A First-in-Class Therapeutic Antibody for Treatment of Acromegaly

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-S (10)]


ADMINISTERING_IC: DE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Dental, Oral, and Craniofacial Disease;HIV/AIDS;Infectious Diseases;Prevention;Social Determinants of Health

ORG_CITY: ALEXANDRIA

ORG_NAME: INTERNATIONAL ASSN FOR DENTAL RESEARCH

ORG_STATE: VA

PHR: Project Narrative Many communities such as at-risk populations of men who have sex with men, transgender people, sex workers, people who use drugs, and adolescents, still lack access to HIV/AIDS prevention, treatment, and care services that they need due in part to HIV-related stigma and discrimination which impedes the current response to HIV/AIDS around the world. WW9 will appraise the state of the science, foster research collaborations, share resources and findings with early career investigators, and identify research gaps, with special attention to the oral health care and disease in high-risk populations including transgender communities. It is anticipated that those receiving support from this grant will take the knowledge acquired at the workshop back to and apply it in their own programs, thus contributing to HIV/AIDS research, care, and education in their own countries.

PI_NAMEs: FOX, CHRISTOPHER H (contact)

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adolescent;AIDS prevention;Area;Attention;Award;Back;care systems;career;Caring;Collaborations;Communities;comorbidity;connected health;cost;Country;craniofacial;Dental;Dental Research;Discrimination;Disease;Drug user;early-career faculty;Education;Educational workshop;Equity;Exposure to;Fostering;Funding;Funding Agency;Future;graduate student;Grant;Health;Healthcare;high risk behavior;high risk population;HIV;HIV Infections;HIV/AIDS;improved;India;Individual;Indonesia;Institution;International;Knowledge;Knowledge acquisition;low and middle-income countries;meetings;men who have sex with men;Mouth Diseases;National Institute of Dental and Craniofacial Research;Oral;Oral health;oral HIV;Participant;Patients;Personal Satisfaction;Persons;Populations at Risk;Postdoctoral Fellow;preference;Prevalence;prevention service;Prevention strategy;Process;programs;Publications;Recommendation;Reporting;Research;Research Personnel;Research Priority;Resource Sharing;Resources;response;Science;Scientific Societies;Series;sex;Shapes;social stigma;symposium;Time;tool;transgender;Translating;translational approach;Transportation;Travel;treatment services;trend;Work

PROJECT_TITLE: 9th World Workshop on Oral Health & Disease in AIDS - Translating Knowledge to Improve Equitable Oral Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 JC (11)]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: SYDNEY

ORG_COUNTRY: AUSTRALIA

ORG_FIPS: AS

ORG_NAME: UNIVERSITY OF SYDNEY

PHR: PROJECT NARRATIVE During effective antiretroviral therapy, human immunodeficiency virus (HIV) persists in memory T cells and the virus from this cellular reservoir typically rebounds when people living with HIV (PLWH) stop therapy. In a clinical study where PLWH underwent 3 consecutive treatment interruptions, we observed that 10% of the participants controlled their viral rebound after the repeated treatment interruptions. This study will determine the viral and immunological mechanisms contributing to viral control in the absence of therapy, accelerating the development of therapeutic strategies that enhance host immunity against HIV with the ultimate goal of achieving virological remission.

PI_NAMEs: PALMER, SARAH ELIZABETH (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Acceleration;Acute;antiretroviral therapy;Binding;Biological Assay;CD8-Positive T-Lymphocytes;Cells;Characteristics;Clinical Research;Clinical Trials;Development;Disease remission;DNA;DNA sequencing;experience;Exposure to;Genetic;Goals;HIV;HIV Antigens;HIV Infections;Immune;Immune response;Immunity;Immunologic Factors;Immunologics;improved;Infection;Interruption;Length;Mediating;Mutate;Mutation;novel;novel therapeutic intervention;Participant;participant enrollment;Persons;Plasma;Population;Protein Region;protein structure;Proteins;Protocols documentation;Proviruses;response;RNA;RNA Sequences;Shapes;T cell response;T memory cell;therapeutic development;Time;transcriptome sequencing;Viral;Viral Load result;Viral Proteins;viral rebound;Viremia;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Delineating the viro-immunological factors contributing to transient HIV control during consecutive analytical treatment interruptions

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Brain Disorders;HIV/AIDS;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: NORFOLK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: OLD DOMINION UNIVERSITY

PHR: Narrative Microglia play critical roles in maintaining brain homeostasis as well as aging. Reversing or eliminating senescent Mg and replenishing with new-born Mg have been suggested as treatment for aging and neurodegenerative disease. Explore whether Mg depletion and repopulation (MgDR) could have therapeutic effects on HIV- associated neurological disorders could provide a novel treatment to improve life quality of chronic HIV (+) individuals.

PI_NAMEs: GUO, MINGLEI  (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Acceleration;Acute Brain Injuries;Adult;Aftercare;Age;Aging;aging brain;Alzheimer's Disease;antiretroviral therapy;Anxiety;behavior test;Blood;Brain;brain dysfunction;Brain Injuries;Brain Pathology;brain repair;Brain-Derived Neurotrophic Factor;Chronic;Cognitive;Data;Defect;differential expression;Disease;DLG4 gene;effective therapy;Enzyme-Linked Immunosorbent Assay;Feeling suicidal;Gender;high reward;high risk;Hippocampus;HIV;HIV Infections;HIV-associated neurocognitive disorder;Homeostasis;IL6 gene;Impaired cognition;improved;in vivo;Incidence;Individual;Inflammation;Interleukin-1 beta;Life Expectancy;Lipids;Lipofuscin;Liver;Locomotion;Lung;Macrophage;male;Mechanics;Memory;Memory impairment;Mental Depression;Microglia;middle age;Monitor;Morphology;Mus;neuroAIDS;Neurodegenerative Disorders;neuroinflammation;Neurologic;neuropsychiatric disorder;neuropsychiatric symptom;Newborn Infant;novel;novel therapeutic intervention;Organ;Pathogenesis;Pathologic;Pathway interactions;Penetration;Peripheral;Phagocytosis;Pharmaceutical Preparations;Phenotype;Physiological;Pilot Projects;Play;Population;Preparation;Preventive;Proteins;Quality of life;Quantitative Reverse Transcriptase PCR;Rat Transgene;Reactive Oxygen Species;Regimen;Research;restoration;RNA;Rodent Model;Role;senescence;Signal Transduction;Spleen;Synapses;System;Testing;Therapeutic;Therapeutic Effect;TNF gene;transcriptome sequencing;Western Blotting

PROJECT_TITLE: Mg-based therapy for mitigating HAND and neuropsychiatric symptoms in the condition of chronic HIV infection

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE We will develop a series of trimeric HIV-1 envelope glycoprotein (Env) antigens designed to elicit a subclass of neutralizing antibodies whose progenitors are abundant in uninfected persons. We will then demonstrate our ability to transform these antibodies into broadly HIV-1 neutralizing antibodies (bnAbs) in our newly developed mouse model that emulates key aspects of the human antibody response.

PI_NAMEs: FARZAN, MICHAEL R. (contact)

PROGRAM_OFFICER_NAME: CHAKRABARTI, BIMAL KUMAR

PROJECT_TERMS: Affinity;Amino Acids;Antibodies;Antibody Repertoire;Antibody Response;Antibody-mediated protection;antigen binding;Antigens;Apical;B Cell Proliferation;B cell repertoire;B-Cell Antigen Receptor;B-Lymphocytes;Binding;Characteristics;Chimera organism;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;Complementarity Determining Regions;Consensus Sequence;Cryoelectron Microscopy;design;Development;Engraftment;Epitopes;Event;Family;Frequencies;Genes;Glycoproteins;Goals;HIV;HIV Seronegativity;HIV-1;HIV-1 vaccine;Human;human model;Humoral Immunities;Immunity;Immunization;Immunize;Immunodominant Epitopes;immunogenic;immunogenicity;Immunoglobulin Somatic Hypermutation;in vivo;insight;Laboratories;Libraries;Light;lipid nanoparticle;Macaca;Mediating;Modeling;mouse model;mRNA delivery;Mus;neutralizing antibody;novel;pandemic disease;Pathway interactions;Persons;Physiological;Polysaccharides;Population Heterogeneity;prevent;Process;progenitor;Property;Proteins;rational design;response;Rodent;Series;Structure;Surface;Technology;Testing;Transgenic Mice;Transmembrane Domain;transmission process;tyrosine O-sulfate;Vaccination;vaccination strategy;vaccine evaluation;vaccine strategy;Vaccines;Variant;Virus;Wild Type Mouse;Writing;Yin

PROJECT_TITLE: An Env apex-focused HIV-1 vaccine strategy


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention

ORG_CITY: HERSHEY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE Despite clear evidence at the couple-level that HIV test-and-treat strategies are successful at reducing HIV transmission, population-level trials have shown mixed effectiveness of test-and-treat strategies to reduce HIV incidence. Through network analyses and simulations, contextualized with community interviews, this career development award will assess whether sexual network clustering impacts the effectiveness of HIV treatment as prevention in Malawi, Uganda, and Nigeria, to help us better understand situations where the population- level impact of test-and-treat strategies are successful and where they are not. These results will inform population-level treatment targets and will allow tests of the utility of network-driven strategies to drive testing and treatment, providing clear guidance to maximize the impact of these interventions.

PI_NAMEs: RISHER, KATHRYN  (contact)

PROGRAM_OFFICER_NAME: SCOTT-SHELDON, LORI ANN JENNIFER

PROJECT_TERMS: Africa South of the Sahara;Age;arm;career;career development;Caring;Characteristics;Cohort Studies;Collaborations;Communities;Couples;Data;Data Collection;Disparity;Effectiveness;effectiveness testing;efficacy testing;Epidemic;experience;Funding;Future;General Population;high risk population;HIV;HIV Infections;HIV Seropositivity;Human immunodeficiency virus test;Incidence;Individual;Intervention;Interview;K-Series Research Career Programs;Malawi;marginalized population;men who have sex with men;Mentorship;Modeling;Morbidity - disease rate;mortality;network models;Newly Diagnosed;Nigeria;novel;Partner Notification;Pathway Analysis;Persons;Population;population based;Positioning Attribute;prevent;randomized trial;Reporting;Research;Risk;Science;Sexual Partners;simulation;skills;sociodemographics;Source;South Africa;Structure;Study models;success;Testing;Training;transgender women;Translating;Translations;transmission process;treatment as prevention;Treatment Efficacy;Uganda;uptake;Viral;Work

PROJECT_TITLE: Sexual network structure and HIV testing and treatment in sub-Saharan Africa: understanding the implications for ending the HIV epidemic.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-Y (03)]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Depression;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Mental Health;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Despite the widespread use of efficacious antiretroviral therapies in controlling peripheral infection and improving life of HIV patients, impulsivity, cognitive depression has become an urgent issue in in people living with HIV (PLWH) in concurrent with substance use. In the United States, approximately 39% of HIV-infected individuals are reported to suffer from depression and the lifetime prevalence of depression in PLWH (11.9%) is twice higher than in the general population (4.6%). This project will determine a novel, previously uncertain molecular mechanism(s) driving Tat-induced dysfunction of monoamine system by direct interaction with serotonin transporter, which is associated with Tat-induced impulsivity and depression-like behavior.

PI_NAMEs: MCLAUGHLIN, JAY P.;ZHAN, CHANG-GUO ;ZHU, JUN  (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: Acute;Amygdaloid structure;antiretroviral therapy;Attenuated;attenuation;Automobile Driving;Behavior;Behavioral;Behavioral Model;Binding;Binding Sites;Brain;Brain region;Calcium;Cell Line;Chemicals;Chemosensitization;Chronic;Cocaine;Cocaine Abuse;cocaine exposure;cocaine reward;cocaine use;Cognitive;Computer Models;Control Animal;Data;depressive behavior;depressive symptoms;Dopamine;dopamine transporter;Exhibits;experience;Exposure to;Face;Fiber;Functional disorder;Funding;General Population;genetic approach;high risk;Hippocampus;HIV;HIV Infections;HIV Seropositivity;HIV-1;Homeostasis;Human;humanized mouse;Hybrids;Impaired cognition;improved;Impulsive Behavior;Impulsivity;In Vitro;in vivo;Incidence;Individual;Infection;inhibitor;insight;Intervention;Knock-in;Life;Medial;Mediating;Mental Depression;Midbrain structure;Modeling;Molecular;molecular dynamics;monoamine;mouse model;Mus;mutant;Mutate;Mutation;Nervous System Trauma;neuroAIDS;neuroblastoma cell;Neurocognitive Deficit;noradrenaline transporter;novel;novel therapeutics;Patients;PC12 Cells;Periodicity;Peripheral;Persons;pharmacologic;Photometry;Physiological;Population;Prefrontal Cortex;Prevalence;Reporting;Role;Scanning;Serotonin;serotonin transporter;Severities;Site-Directed Mutagenesis;Slice;Social Interaction;Substance abuse problem;substance use;Synapses;System;tat Protein;Therapeutic;Therapeutic Intervention;Transgenic Mice;Transgenic Organisms;transmission process;United States;uptake;Validation;Viral Proteins;Virion

PROJECT_TITLE: Molecular mechanisms: Dysregulation of monoamine transporters by HIV-1 Tat and cocaine


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Many people with HIV live in resource-deprived neighborhoods that are harmful to their health. This research addresses the effects of neighborhood deprivation on the health of people with HIV. The knowledge gained will inform policies and programs that improve health and reduce health inequities among people with HIV.

PI_NAMEs: ZALLA, LAUREN C. (contact)

PROGRAM_OFFICER_NAME: ROE, JOANAD'ARC C

PROJECT_TERMS: Accounting;Address;Adult;Affect;Applied Skills;Area;Award;Baltimore;Black race;care outcomes;career;Caring;Censuses;Cessation of life;Cities;Clinic;Clinical;clinical care;cohort;comparative;Continuity of Patient Care;County;Death Rate;deprivation;design;Environment;Epidemic;Epidemiologist;epidemiology study;Equity;Exposure to;Foundations;Funding;Future;Gender;Goals;Health;health care disparity;health determinants;health disparity;health equity;health inequalities;Health system;Hispanic;HIV;HIV diagnosis;improved;Incentives;Incidence;indexing;Individual;Institution;Interruption;Intervention;Investments;Knowledge;Link;Longitudinal Studies;Maryland;Measures;Mentorship;Methods;mortality;Neighborhoods;Newly Diagnosed;Outcome;Participant;Pathway interactions;patient health information;Patients;Persons;Phase;Policies;Population;population health;Privatization;programs;Public Health Schools;Public Policy;Qualifying;Race;Recording of previous events;Reduce health disparities;Research;Resources;Role;secondary analysis;Series;Services;Shapes;skills;social group;social health determinants;Social stratification;social vulnerability;Socialization;structural health determinants;Study Skills;Taxes;Time;Training;transmission process;United States;urban setting;Viral;Work

PROJECT_TITLE: The Urban Environment as a Modifiable Social Determinant of Health among People with HIV

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Cardiovascular;Clinical Research;Contraception/Reproduction;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Experiences of stress and trauma across the life course may result in poor cardiometabolic outcomes during pregnancy, postpartum, and later life. This project aims to use data on stress and trauma across the life course to examine the impact of cumulative stress on cardiometabolic function during pregnancy and following childbearing and cardiometabolic risk behaviors postpartum. The results of this project will inform theory, potential intervention development, and the understanding of the impact of stress and trauma on health.

PI_NAMEs: STANHOPE, KAITLYN K (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Adult;adverse pregnancy outcome;Behavior;biological adaptation to stress;Biological Markers;Black race;Blood;Blood Pressure;Body mass index;Body Weight decreased;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;child bearing;Childhood;Clinic;Clinical;cohort;Communities;Conceptions;Data;Data Collection;data registry;Data Set;depressive symptoms;Development;Diagnosis;diet and exercise;Discipline of obstetrics;Disparity population;Environment;Epidemiology;experience;Exposure to;Face;Family;fasting glucose;follow-up;Functional disorder;Gestational Diabetes;Goals;Health;Health Services Accessibility;high risk;Hypertension;Income;Individual;infant outcome;Lactation;late life;Life Cycle Stages;Life Stress;Lipids;long-term sequelae;Longitudinal Studies;Low income;maternal morbidity;Maternal Mortality;maternal risk;Measurement;Measures;Mediation;Medical;Medical Records;Mentors;Mentorship;Metabolic;middle age;Modeling;Modification;multi-ethnic;Neighborhoods;Not Hispanic or Latino;novel;Outcome;Participant;Pattern;Perinatal;Persons;Phase;placental morphology;post pregnancy;Post-Traumatic Stress Disorders;postpartum outcome;Postpartum Period;postpartum weight;Postpartum Women;Pregnancy;Pregnancy Complications;pregnancy disorder;Pregnancy Histories;pregnant;Pregnant Women;prenatal;prevent;Prevention strategy;prospective;Prospective, cohort study;psychosocial wellbeing;Questionnaires;racial disparity;racial minority;racism;rate of change;Recording of previous events;recruit;Registries;Research;Risk;Risk Behaviors;Risk Factors;Role;Sampling;Secondary Prevention;Sleep;sleep quality;social health determinants;Social support;socioeconomic disparity;Stress;stressor;structural determinants;Surveys;Symptoms;theories;therapy development;Time;Training;Trauma;United States;Urine;Woman

PROJECT_TITLE: Accumulation of stress and trauma across the life course and cardiometabolic risk during pregnancy and postpartum

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ORG_CITY: PITTSBURGH

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: This competitive renewal application will assess the role of microbiome in inducing intestinal dysfunction and progression to AIDS in people living with HIV (PWH). Enteropathy is characteristic to HIV/SIV infection and was described early in the pandemic, but a direct causative relationship between GI dysfunction and HIV/SIV disease progression has yet to be established. Natural hosts of SIVs (i.e., African green monkeys, AGMs) are ideal for dissecting the relative contribution of the different potential mechanisms resulting in mucosal dysfunction, because they maintain mucosal integrity throughout infection in spite of high levels of viral replication. We designed a set of interventions in the AGMs to induce dysbiosis, mucosal damage and/or impact liver clearance of the translocated microbes and thus dissect the mechanisms that may impact GI integrity and disease progression in HIV infection. Our studies may thus inform future therapeutic strategies aimed to alleviate gut dysfunction, reduce related comorbidities, improve quality of life and survival in PWH.

PI_NAMEs: APETREI, CRISTIAN ;VASILE PANDREA, IVONA  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, KHOA DINH DANG

PROJECT_TERMS: Abbreviations;Acquired Immunodeficiency Syndrome;adaptive immune response;Address;Adipose tissue;African Green Monkey;Alcohols;Anti-Inflammatory Agents;Anti-Retroviral Agents;Antibiotics;Antibodies;antiretroviral therapy;Atherosclerosis;Automobile Driving;Behavioral;Cardiovascular system;CD4 Positive T Lymphocytes;Cell Death;Characteristics;Chemicals;Circulation;Clinical;comorbidity;Complex;Consumption;Coupled;Data;design;Development;Diphtheria Toxin;Disease Progression;Dissociation;dysbiosis;Epithelium;experimental study;Functional disorder;Funding;Future;gastrointestinal;gastrointestinal epithelium;Gastrointestinal tract structure;gut microbiome;Gut Mucosa;Heavy Drinking;High Fat Diet;HIV;HIV Enteropathy;HIV Infections;HIV/AIDS;immune activation;Immunohistochemistry;Immunologics;impaired capacity;improved;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;inflammatory milieu;Innate Immune Response;Interleukin-2;Intervention;Intestinal permeability;Intestines;Intravenous;Liver;Macaca mulatta;Macaca nemestrina;Microbe;microbial;microbial products;microbiome;Modeling;Mucous Membrane;Outcome;pandemic disease;Pathogenicity;Pathway interactions;Persons;Play;preservation;prevent;Prognosis;Quality of life;Role;SIV;Sodium Dextran Sulfate;T-Cell Activation;T-Cell Depletion;T-Lymphocyte;Testing;Therapeutic;Therapeutic Intervention;thrombotic;Vancomycin;Viral Load result;virtual;Virus;Virus Replication;western diet

PROJECT_TITLE: Assessing the Role of GI Tract Dysfunction to HIV/SIV Disease Progression


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_CITY: BLOOMINGTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative Although antiretroviral therapies are effective at improving long-term outcomes for people living with HIV-1, the narrow selection of antiretrovirals against drug-resistant HIV strains necessitate the search for alternative viral targets for inhibition. An essential yet poorly understood step in HIV replication is Rev-response element (RRE) mediated nuclear export of the viral RNAs. This project will establish a mechanistic and structural basis for RRE and Rev protein interaction, and provide a new avenue for development of novel antiretroviral drugs.

PI_NAMEs: CHOI, KYUNG H (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: 3-Dimensional;Acquired Immunodeficiency Syndrome;Affinity;AGFG1 gene;Anti-Retroviral Agents;Antibodies;antiretroviral therapy;Architecture;Binding;Binding Proteins;Binding Sites;Biochemical;Biological;Biological Assay;Cell Nucleus;Cells;Complex;Cryoelectron Microscopy;Cytoplasm;Development;dimer;drug development;effective therapy;Event;Generations;Heterogeneity;HIV;HIV drug resistance;HIV Infections;HIV-1;image processing;Immune system;Immune Targeting;improved;Infection;insight;Introns;Investigation;Laboratories;Left;Length;Life Cycle Stages;Malignant Neoplasms;Mediating;Messenger RNA;Modeling;Molecular Conformation;Molecular Structure;mRNA Translation;mutant;novel;Nuclear Export;Outcome;Patients;Persons;Pharmaceutical Preparations;Phase;Prevention;Process;Protein Biosynthesis;reconstruction;recruit;Resolution;Response Elements;rev Protein;RNA;RNA Sequences;RNA Splicing;scaffold;Shapes;stem;Structure;System;Testing;therapeutic development;therapeutic target;Transcript;Transfer RNA;Variant;Viral;Viral Proteins;viral RNA;Virion;Virus Assembly;X-Ray Crystallography

PROJECT_TITLE: Structure of HIV Rev response element

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CORAL GABLES

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE The proposed research examines the configurations of online gaming and offline friendship networks of Latinx men who have sex with men (LMSM) and the extent to which these network structures and compositions can influence LMSM access to pre-exposure prophylaxis (PrEP) information and promote the distribution of HIV self- testing kits (HIVST). This mixed-methods study will utilize dyadic, egocentric, and two-mode network visualizations and analyses and qualitative interview data to inform the development and implementation of culturally-tailored game- and social network-based interventions to enhance HIV prevention services for LMSM and other underserved communities. These findings will guide the development of the applicant’s future K99/R00 application.

PI_NAMEs: CRAKER, LACEY  (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Address;Adult;AIDS prevention;Area;Attitude;Award;Awareness;Behavior;behavior change;Characteristics;combination intervention strategy;Communication;Communities;community partners;Computers;contagion;County;Data;Data Analyses;Data Sources;density;design;Detection;Development;Diagnostic Reagent Kits;Diffusion;digital health;disadvantaged background;Ego;Elements;Epidemic;ethnic minority population;Ethnic Origin;experience;Florida;Fostering;Foundations;Frequencies;Friends;Friendships;Future;Gender;gender minority group;gender minority youth;Goals;Health;Health behavior;health disparity;Health education;Health Knowledge Attitudes Practice;HIV;improved;Incidence;Individual;infancy;Intervention;Interview;Knowledge;Latino Population;Latinx;Latinx population;medical schools;member;men who have sex with men;Mentors;Methods;metropolitan;mHealth;Modeling;network models;Network-based;outreach program;Pathway Analysis;Persons;Play;pre-exposure prophylaxis;predoctoral investigator;Prevalence;prevention service;preventive intervention;racial disparity;racial minority population;Research;research and development;Research Methodology;Research Personnel;Role playing therapy;self testing;Services;Sex Orientation;Sexual Health;sexual minority group;sexual minority men;sexual minority youth;social;Social Network;social network intervention;social networking website;sociodemographics;Structure;Study of Latinos;testing uptake;theories;therapy design;tool;Training;underserved community;Universities;uptake;Visualization;Work

PROJECT_TITLE: Exploring Acceptability & Potential Reach of Game-Based & Social Network Strategies for Improving PrEP & HIV Self-Testing Uptake among Latinx Sexual Minority Men Living in an EHE Priority Jurisdiction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F17B-K (20)]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Genetics;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Perinatal Period - Conditions Originating in Perinatal Period

ORG_DEPT: PEDIATRICS

PHR: HIV-1 creates a hidden pool of proviruses that allow the virus to rebound after treatment. The proposed studies will help researchers learn about these proviruses and how they function in newborns and infants. This research will identify which therapies work on which proviruses, advancing the hope of drug-free remission for children who would otherwise face a lifetime of treatment.

PI_NAMEs: PERSAUD, DEBORAH  (contact)

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: Adult;Aftercare;Antibody Therapy;antiretroviral therapy;Binding;Biological Assay;Biological Markers;Birth;Cells;Child;Childhood;Clinical Trials;Clinical Trials Network;Clonal Expansion;Clonality;Collaborations;Collecting Cell;Data;Disease remission;DNA;Early treatment;efficacy trial;Enrollment;Evaluation;Event;Evolution;Face;Genes;Genetic Transcription;genome sequencing;Genomic DNA;Genotype;HIV;HIV-1;Hour;immune clearance;Immunotherapeutic agent;improved;in silico;in utero;Infant;Infection;insight;integration site;International Maternal Pediatric Adolescent AIDS Clinical Trials;Interruption;Intervention Trial;Investigation;latent HIV reservoir;Learning;Length;Life;memory CD4 T lymphocyte;Molecular;Neonatal;neonate;neutralizing antibody;Newborn Infant;NIH Vaccine Research Center;novel;novel therapeutic intervention;Participant;perinatal HIV;Perinatal transmission;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Phenotype;Population;postnatal;Predisposition;prenatal;Prevalence;prevent;Prevention strategy;Proviruses;Regimen;Repetitive Sequence;Reporting;Research;Research Personnel;Resistance;Rest;Testing;Therapeutic;Therapeutic Intervention;Time;United States National Institutes of Health;Vertical Transmission;Viral;Viremia;Virus;Work

PROJECT_TITLE: Impact of Neonatal ART and Broadly Neutralizing Antibodies on HIV-1 Reservoirs in Infants: Towards ART-free Remission


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Rural Health

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative In collaboration with the Shelby County Health Department and other health jurisdictions, we will simulate alternative policies to maximally reduce HIV incidence and improve overall health in three settings (New York City, Memphis, and northwest Mississippi). We will place special emphasis on the role of alcohol, substance and mood disorders on HIV transmission and progression. We will also incorporate inequality-aversion measures to address uneven health burden in vulnerable subgroups.

PI_NAMEs: BRAITHWAITE, RONALD SCOTT (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adjusted Life Years;AIDS prevention;Alcohols;Arkansas;Benchmarking;Black American;Budgets;Caring;caucasian American;Cities;cofactor;Collaborations;Country;County;Diagnosis;Epidemic;Ethnic Population;Funding;Goals;Health;HIV;HIV Infections;HIV risk;improved;Incidence;Inequality;Inequity;Injectable;insight;interest;International;Intervention;Link;Location;mathematical model;Measures;Mental Health;Mississippi;Modality;Modeling;Mood Disorders;Moods;New York City;Newly Diagnosed;Outcome;outcome disparities;Pattern;Persons;Policies;Population;pre-exposure prophylaxis;prevent;Quality-Adjusted Life Years;Race;racial population;Recommendation;Resource Allocation;Resources;Risk;Risk Behaviors;Role;Rural;screening;Specificity;Subgroup;Target Populations;Testing;Time;transmission process;Viral Load result;willingness;willingness to pay;Work

PROJECT_TITLE: Are Ending the HIV Epidemic goals attainable across race/ethnic groups, risk groups, and settings?

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE PrEP My Way is a novel PrEP delivery system consisting of clinic-based PrEP initiation, followed by peer- delivered kits for HIV self-testing, PrEP refills, vaginal swabs for sexually transmitted infection self-sampling, pregnancy tests, and family planning, if desired. When combined with choice of PrEP formulation and adherence support tools, PrEP My Way is well positioned to create an optimized means to promote adherence and persistence to PrEP among young women in sub-Saharan Africa. This study will test the impact of PrEP My Way versus enhanced standard of care on PrEP use among young women in Kisumu, Kenya, while also determining key implementation metrics, including cost, to promote future integration and scale-up of the intervention within Kenya Ministry of Health HIV prevention efforts.

PI_NAMEs: BUKUSI, ELIZABETH ANNE;HABERER, JESSICA ELIZABETH (contact)

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;Adherence;Africa;Africa South of the Sahara;African Women;Age;AIDS prevention;arm;Blood;Caregivers;Caring;Client;Clinic;clinical care;Clinical effectiveness;Clinical Trials;Communities;Community Health Aides;Contraceptive methods;cost;cost effectiveness;Cost Effectiveness Analysis;cost-effectiveness ratio;Coupled;Dapivirine;Data;design;Dryness;Educational workshop;effectiveness/implementation design;effectiveness/implementation trial;Eligibility Determination;empowerment;emtricitabine;Enrollment;Ensure;Environment;evidence base;experience;Family Planning;Formulation;Future;group intervention;Health;health care delivery;Health Services;HIV;HIV Infections;HIV risk;Human immunodeficiency virus test;Hybrids;implementation science;improved;Incidence;incremental cost-effectiveness;Individual;Infection;Injectable;Injections;innovation;Intervention;Interview;Kenya;microcosting;Modeling;novel;Nurses;Oral;Outcome;Participant;Patient Self-Report;peer;peer support;Pharmaceutical Preparations;Plasma;Population;Positioning Attribute;pre-exposure prophylaxis;Pregnancy Tests;Prevention;primary outcome;Privacy;Process;Proctor framework;programs;Publishing;Randomized;Regulation;Reporting;Research;Research Personnel;routine care;Safety;Sampling;scale up;secondary outcome;self testing;Services;Sexual Health;Sexual Partners;Sexually Transmitted Diseases;skills;social cognitive theory;social stigma;Spottings;standard of care;success;supply chain;support tools;Swab;System;Tenofovir;Testing;therapy design;Time;Time and Motion Studies;Translating;Unsafe Sex;uptake;user-friendly;Vagina;Vaginal Ring;Woman;young man;young woman

PROJECT_TITLE: PrEP My Way: A hybrid type 1 clinical effectiveness-implementation trial to promote PrEP persistence among young Kenyan women

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases

ORG_CITY: PROVIDENCE

ORG_NAME: MIRIAM HOSPITAL

ORG_STATE: RI

PHR: HIV Drug Resistance in the New ART Era in Kenya Rami Kantor, MD NARRATIVE This Proposal aims to thoroughly study drug resistance in people with HIV in a large healthcare program in western Kenya, at a time when new and improved medications are being widely introduced for HIV treatment. This approach will enable us to study the expected rise in development of resistance to these medications over time, and gain insights on how to improve patient care and address the increasing global challenge of HIV drug resistance in the era of new HIV therapy.

PI_NAMEs: KANTOR, RAMI  (contact)

PROGRAM_OFFICER_NAME: CRAWFORD, KEITH W

PROJECT_TERMS: acquired drug resistance;Address;Adherence;advanced disease;Affect;Anti-Retroviral Agents;Anti-retroviral drug resistance;antiretroviral therapy;Caring;clinical care;co-infection;Collaborations;comorbidity;Country;Data;design;Development;drug development;Drug Interactions;Drug resistance;emerging virus;Enrollment;Ensure;Epidemic;experience;Failure;fighting;Formulation;Frequencies;Future;Guidelines;Healthcare;HIV;HIV drug resistance;HIV resistance;HIV therapy;HIV-1;HIV/TB;improved;Individual;inhibitor;inhibitor therapy;insight;Integrase;International;Interruption;Intervention;Kenya;Location;Monitor;novel therapeutics;Patient Care;Patient Monitoring;Persons;Pharmaceutical Preparations;Polypharmacy;Pregnancy;Process;programs;prospective;Race;Regimen;Research;Resistance;Resistance development;resistance mechanism;Resource-limited setting;Risk;scale up;Shapes;Special Population;success;Testing;Time;timeline;Toxic effect;transmission process;Treatment Failure;Uncertainty;Vertical Transmission;Viral Load result;viral resistance;Viremia;Virus;Zidovudine

PROJECT_TITLE: HIV Drug Resistance in the New Antiretroviral Therapy Era in Kenya


NIH_SPENDING_CATS: Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Emergency Care;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: STANFORD

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE Emergency departments (EDs) provide a growing amount of all care in the U.S. but, compared with other settings, have some of the lowest rates of HIV testing; decision makers in EDs cite several barriers to more routine HIV testing, including concerns about cost and the impact of increased testing on overcrowding and boarding. Given the public health benefits of more routine HIV screening, Dr. Bennett proposes to investigate the cost-effectiveness of ED-based HIV screening, to create a typology of HIV screening strategies used by 28 local EDs that recently received funding to implement or expand routine, opt-out HIV screening, and to illuminate barriers and facilitators encountered during the real-world implementation of HIV screening programs by employing semi-structured interviews of frontline ED providers implementing HIV screening and persons tested for HIV. These analyses will help guide decision-makers toward effectively deploying available resources to optimize ED-based HIV screening among their unique populations, providing valuable knowledge to help EDs play a more active role in ending the HIV epidemic.

PI_NAMEs: BENNETT, CHRISTOPHER L (contact)

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: Accident and Emergency department;American;antiretroviral therapy;Award;Benchmarking;California;career development;Caring;Charge;clinical training;cohort;Collaborations;Communities;Consolidated Framework for Implementation Research;cost;Cost Analysis;cost effective;cost effectiveness;Cost Effectiveness Analysis;cost-effectiveness ratio;COVID-19 pandemic;Crowding;Data;Death Rate;Decision Aid;design;Early Diagnosis;economic evaluation;Emergency department screening;Emergency Medicine;Epidemic;Epidemiology;ethnic minority population;experience;Extramural Activities;Funding;Future;gender minority group;Geographic Locations;Goals;Health Benefit;health care settings;Health Services Research;Healthcare;Healthcare Systems;HIV;HIV Infections;HIV/AIDS;Human immunodeficiency virus test;implementation science;implementation strategy;improved;Incidence;incremental cost-effectiveness;Individual;Infection;innovation;insight;Interview;Knowledge;Lead;Life Expectancy;member;Mentors;Mentorship;Minority;Mission;multidisciplinary;National Institute of Allergy and Infectious Disease;Outcome;patient oriented;Patients;Pattern;Persons;Physicians;Play;Population;Populations at Risk;Positioning Attribute;Poverty;pragmatic implementation;Preventive care;Preventive Health Services;Preventive service;Process;professor;Provider;Public Health;public health relevance;Publishing;Qualitative Methods;racial minority population;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Personnel;Resources;Role;routine screening;Scientist;screening;screening program;Secure;sexual minority group;Sexually Transmitted Diseases;Site;social health determinants;Source;stem;Strategic Planning;Structure;Techniques;Testing;Training;Typology;Uninsured;United States National Institutes of Health;Universities;Update;uptake;Variant;Work

PROJECT_TITLE: Cost-Effectiveness of HIV Testing in U.S. Emergency Departments


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

PHR: PROJECT NARRATIVE Despite the availability of antiviral drugs as treatment and prevention strategies for HIV, there is still no cure and there are ongoing challenges with adherence and delivery of current daily regimens. Our approach is to develop a new slow-releasing formulation for highly potent antiviral drugs that will provide a novel delivery system using biodegradable microneedle patches that can be painlessly self-administered and can be used in adult and pediatric populations. This approach could provide a strategy for simplified, long-term administration of antiviral drugs for up to several months to increase medication adherence and treatment efficacy.

PI_NAMEs: PRAUSNITZ, MARK R.;TAO, SIJIA  (contact)

PROGRAM_OFFICER_NAME: PROTOPOPOVA, MARINA

PROJECT_TERMS: 2'-deoxyadenosine;Adherence;Adult;Africa South of the Sahara;Animals;Anti-Retroviral Agents;Anti-viral Agents;biodegradable polymer;Biological Assay;Biomedical Engineering;Blood;Caring;Cessation of life;Child;Childhood;Clinical;Clinical Data;Collaborations;Contraceptive Agents;Data;design;Development;Dose;Drug Administration Routes;Drug Delivery Systems;Drug Kinetics;emtricitabine;Encapsulated;experience;Family suidae;Formulation;Funding;Future;Goals;Half-Life;HIV;HIV Infections;HIV-1;Homelessness;Hormones;Implant;improved;In Vitro;in vivo;inhibitor;Injections;Kinetics;Lamivudine;Lymphocyte;Measures;Mechanics;Medical;medication compliance;Medicine;nanomolar;Needles;New Zealand;novel;novel therapeutics;Nucleosides;Oral Administration;Oryctolagus cuniculus;Outcome;Painless;pediatric patients;Persons;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;Phase II Clinical Trials;phase III trial;Plasma;poly(lactic acid);polycaprolactone;Polyvinyl Alcohol;Polyvinyls;Population;Populations at Risk;prevent;Prevention;Prevention strategy;prophylactic;Prophylactic treatment;Pyrrolidinones;Quality of life;Rattus;Regimen;Research;Research Personnel;Resource-limited setting;RNA-Directed DNA Polymerase;Sampling;Seasons;Self Administration;Skin;skin patch;Solvents;Subcutaneous Injections;Sucrose;Surface;System;Tablets;technology development;technology platform;Testing;Therapeutic;transmission process;Treatment Efficacy;treatment strategy;tripolyphosphate;United States National Institutes of Health;Universities;Water;Work

PROJECT_TITLE: Self-administered microneedle patch for long-acting release of antiretroviral agents


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;HIV/AIDS;Hematology;Infectious Diseases;Lung;Prevention;Pulmonary Hypertension;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

PHR: PROJECT NARRATIVE Despite the advent of combination antiretroviral therapy, people with HIV (PWH) still suffer from lung and heart diseases, which contribute to the dramatic reduction of their life expectancy. Despite this knowledge, the mechanisms damaging the blood vessels of the lungs of PWH remain ill-defined and unstudied. The proposed study will combine the use of novel genetically engineered animal models, human specimens, and cultured cells with pharmacological approaches to test whether viral proteins produces by HIV damage lung blood vessels.

PI_NAMEs: BELIN DE CHANTEMELE, ERIC J (contact);KOVACS, LASZLO

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Acceleration;Adoptive Transfer;Aging;aging related;AIDS prevention;American;Animal Model;Antibodies;antiretroviral therapy;Aorta;blood damage;Blood Vessels;Bone Marrow Transplantation;Cardiopulmonary;cardiovascular disorder risk;Cardiovascular system;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Proliferation;Cell Separation;Cells;Chronic;Chronic Disease;Circulation;Coculture Techniques;Collagen;Cultured Cells;Data;Deposition;Development;Disease;Exposure to;Female;Genetic;Genetic Engineering;Heart Diseases;Hematopoietic;high risk;HIV;HIV diagnosis;HIV Seropositivity;HIV-1;Human;in vivo;Individual;inhibitor;Interleukins;Knowledge;Life Expectancy;Lung;Lung Diseases;lung injury;male;Measures;Mediating;Molecular;mouse model;Mus;neutralizing antibody;new therapeutic target;novel;novel marker;novel therapeutics;Outcome;overexpression;Pathologic;Peripheral Blood Mononuclear Cell;Persons;pharmacologic;Phenotype;Population;Prevalence;Prevention;Production;promoter;Prophylactic treatment;Proteins;Pulmonary arterial remodeling;Pulmonary artery structure;Pulmonary Heart Disease;pulmonary vascular cell proliferation;pulmonary vascular disorder;pulmonary vascular remodeling;Reporting;Right Ventricular Hypertrophy;Role;Sex Differences;Signal Pathway;single-cell RNA sequencing;Smooth Muscle Myocytes;Specimen;System;Systolic Pressure;T-Lymphocyte;tat Protein;Testing;Time;transcriptome sequencing;transcriptomics;Vascular Smooth Muscle;vascular smooth muscle cell proliferation;Ventricular;Viral;Viral Proteins;Viremia;Wild Type Mouse

PROJECT_TITLE: Novel mechanisms of HIV-associated pulmonary vascular disease


ORG_CITY: SAN ANTONIO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Restriction factors—cellular proteins whose activity interferes with specific steps in viral replication and protects cells against infection—are important components of innate immunity defenses against viral pathogens. Modulating activity of the host’s restriction factors and/or targeting viral evasion from them is an attractive, albeit largely unexplored, intervention strategy for treatment and/or prevention of viral infections. This proposal is focused on SAMHD1, a protein that impedes HIV-1 infection of non-dividing myeloid cells and resting T cells. The goal of the studies described here is to characterize biochemical properties of SAMHD1 and to understand how the biochemical activity of the protein shapes its anti-retroviral function.

PI_NAMEs: IVANOV, DMITRI N (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Affect;Allosteric Regulation;Allosteric Site;Anabolism;Anti-Retroviral Agents;antiviral immunity;Binding;Biochemical;Biochemistry;Biogenesis;Biological Process;Cell Differentiation process;cell growth regulation;Cells;Cytoprotection;Decision Making;DNA biosynthesis;DNA Repair;Equilibrium;Funding;Goals;HIV;HIV Infections;HIV-1;Homeostasis;Human;Hydrolase;Immune;Immune system;Immunologic Factors;Infection;insight;Intervention;Ligands;Mediating;Metabolic;Metabolism;Mitochondria;Modality;Modeling;Molecular Conformation;Mutation;Myeloid Cells;Natural Immunity;novel;Nucleic Acid Binding;Nucleic Acids;Nucleotides;Pathogenesis;pathogenic virus;Pathogenicity;Pathway interactions;permissiveness;Post-Translational Protein Processing;Post-Translational Regulation;Predisposition;Prevention;Process;Production;Property;Proteins;response;Rest;Sampling;Series;Shapes;T-Lymphocyte;Testing;treatment strategy;tripolyphosphate;Viral;viral DNA;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Biochemistry of SAMHD1-mediated innate immunity responses


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Cost Effectiveness Research;Data Science;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE HIV-related opportunistic infections (OIs) cause substantial morbidity and mortality, especially among uninsured people with HIV (PWH), yet machine learning has not been deployed sufficiently to optimize outcomes for PWH. This work will use machine learning to predict the effect of Medicaid expansion on OI hospitalization and mortality rates and use artificial intelligence to predict poor outcomes for PWH with a focus on disadvantaged, priority populations. Quantifying the profound health impact of being uninsured and creating a tool to predict poor outcomes among PWH will provide a lasting foundation to continue working towards the White House Office of National AIDS Policy’s goal of improving HIV-related health outcomes of all PWH.

PI_NAMEs: BIELICK, CATHERINE  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Admission activity;Advisory Committees;Age;AIDS prevention;AIDS-Related Opportunistic Infections;Area;Artificial Intelligence;Award;Biometry;Caring;Cause of Death;Centers for Disease Control and Prevention (U.S.);Cessation of life;Clinical;Code;Collaborations;Communicable Diseases;Communities;Computerized Medical Record;Cost Effectiveness Analysis;COVID-19 pandemic;Data;Data Analytics;Data Science;Data Scientist;data warehouse;Databases;Death Rate;deep learning;deep learning model;demographics;Development;Diagnosis;Disadvantaged;Disease;Disparity;Environment;Ethnic Origin;Failure;Foundations;Future;Gender Identity;Goals;Health;health care availability;health data;health disparity;health inequalities;Health Insurance;Health Sciences;Healthcare;Height;High Performance Computing;high risk;HIV;Hospital Mortality;Hospitalization;hospitalization rates;Hospitals;Immunosuppression;improved;improved outcome;Incidence;Individual;Infection;Inpatients;Institution;Insurance Coverage;Intervention;K-Series Research Career Programs;learning network;long short term memory;Low income;Machine Learning;machine learning method;machine learning model;Measures;Mediating;Medicaid;Mentors;Mentorship;Methods;mHealth;model generalizability;Modeling;modifiable risk;Morbidity - disease rate;mortality;Opportunistic Infections;Outcome;patient population;Persons;Physicians;Policies;Population;Privacy;Public Health;Public Policy;Race;Records;Reporting;Research;Research Personnel;Resources;Risk;Risk Factors;risk prediction;Safety;Sampling;Schools;Series;Site;social health determinants;sociodemographics;Subgroup;Testing;Time;Time Series Analysis;tool;Training;Translating;Underrepresented Populations;Uninsured;United States;Universities;Viral;Viral Load result;Virginia;Work

PROJECT_TITLE: Localizing Health Disparities and Predicting Morbidity and Mortality for HIV-Related Opportunistic Infections


NIH_SPENDING_CATS: Aging;Atherosclerosis;Biomedical Imaging;Cardiovascular;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research

PHR: PROJECT NARRATIVE: People with HIV currently experience an increased risk for atherosclerotic cardiovascular disease (ASCVD), despite successful viral suppression that is not entirely explained by traditional risk factors. Our proposal examines the hypothesis that lipoprotein(a) (Lp[a]), a novel risk factor, and the increased oxidized phospholipids they carry as a result of the pro-inflammatory state associated with HIV, contribute to this HIV-specific increased ASCVD risk. It also examines two proposed mechanisms explaining how Lp(a) contributes to ASCVD risk in people with HIV and the regulation of hepatic Lp(a) production in people with HIV, particularly through the inflammatory cytokine IL-6 signaling pathway.

PI_NAMEs: LEUCKER, THORSTEN M (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Address;antiretroviral therapy;Atherosclerosis;atherosclerosis risk;attenuation;Baltimore;Black Populations;Black race;black women;Blood Vessels;Calcium;cardiovascular disorder risk;Case/Control Studies;Cells;Chronic;Clinical;Clinical Research;cohort;Cohort Studies;Coronary;coronary artery calcium;coronary computed tomography angiography;CRISPR/Cas technology;cytokine;Data;design;Disease;Disease Outcome;Endothelium;Event;experience;exposed human population;Exposure to;Fatty acid glycerol esters;Future;Genetic Transcription;genetic variant;genome wide association study;genomic data;Genomics;Goals;Hepatic;Hepatocyte;Heterogeneity;high risk;HIV;HIV Infections;Human;human induced pluripotent stem cells;IL6 Signaling Pathway;Impairment;improved;In Vitro;indexing;induced pluripotent stem cell;Inflammation;Inflammatory;Interleukin 6 Receptor;Interleukin-6;Knowledge;Life Expectancy;Life Style;Link;Lipoprotein (a);Liver;Magnetic Resonance Imaging;Measures;men;Methods;Modification;MRI Scans;multidisciplinary;novel;Participant;Pathogenesis;Pathway interactions;patient population;Persons;Phospholipids;pre-clinical;preclinical study;preventive intervention;Production;promoter;Proteins;Publishing;Race;racial disparity;recruit;Regulation;Research;response;Risk;Risk Factors;risk prediction;Role;Scanning;Serum;STAT3 gene;Techniques;Testing;Ultrasonography;United States National Institutes of Health;Universities;Variant;Vascular Endothelium;vascular inflammation;Viral;White Women;Woman;Work;X-Ray Computed Tomography

PROJECT_TITLE: Lipoprotein (a) Modification of the Impact of HIV Infection on Atherosclerotic Cardiovascular Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-R (02)]


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative HIV is a chronic disease that fails to be controlled by the immune system, which may stem, in part, from the virus’ ability to infect hard-to-kill immune cells, such as macrophages. In this proposal, I will investigate mechanisms by which HIV-infected macrophages limit killing by natural killer (NK) cells to promote their survival. This work will identify targetable mechanisms of resistance, to be used for future clinical interventions to enhance early control of HIV, and potentially other pathogens that infect macrophages as well.

PI_NAMEs: GRASBERGER, PAULA  (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Activated Natural Killer Cell;Address;Affect;Antibodies;antiretroviral therapy;Apoptosis;Apoptotic;Autologous;Award;Biological Response Modifiers;CASP8 gene;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Death Induction;Cell Degranulation;cell killing;Cell surface;cell type;Cells;Cessation of life;chemokine;Chronic Disease;Clinical;Coculture Techniques;Complement;Confocal Microscopy;CRISPR/Cas technology;cytokine;Cytoplasmic Granules;cytotoxic CD8 T cells;Data;Data Set;Development;Doctor of Philosophy;Effector Cell;experimental study;Exposure to;extracellular;Failure;Fc Receptor;Feedback;Fellowship;Future;Genes;Germ Lines;Goals;Granzyme;HIV;HIV-1;HIV-2;Human;human tissue;Immune;Immune response;Immune system;immunological synapse;Immunology;In Vitro;in vitro Model;in vivo;Incubated;Induction of Apoptosis;Infection;Innate Immune System;insight;International;Interruption;Intervention;Intervention Studies;Knock-out;Ligands;lysosome membrane;Lysosomes;Lytic;Macaca;Macrophage;Massachusetts;Measures;Mediating;medical schools;Melanoma Cell;Membrane;Microbiology;monocyte;Natural Killer Cells;pathogen;Pathogenesis;pathogenic virus;perforin;Persons;Phenotype;Predisposition;Production;Productivity;programs;protein expression;Proteins;Publishing;receptor;Receptor Signaling;Recombinants;repaired;Research;Research Ethics;Research Personnel;Residencies;Resistance;resistance mechanism;Scientist;Side;Signal Transduction;simian human immunodeficiency virus;single-cell RNA sequencing;SIV;Source;stem;Surface;symposium;System;T-Lymphocyte;Technical Expertise;Tissues;TNF-related apoptosis-inducing ligand;Training;Tumor Necrosis Factor Ligand Superfamily Member 6;Universities;viral rebound;Viral reservoir;Virus;Work

PROJECT_TITLE: Characterizing mechanisms by which HIV-infected macrophages neutralize NK cell effector functions to facilitate their persistence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F17A-G (20)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Pediatric;Prevention

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Long-acting injectable antiretroviral therapy (LAI ART) and Pre-Exposure Prophylaxis (LAI PrEP) have the potential to transform HIV treatment and prevention, especially in reaching individuals such as commercial minibus drivers who have minimal or no contact with traditional health facilities. The project proposes to use a culturally appropriate and community-engaged approach to promote the uptake of HIV self-testing, LAI-ART, and LAI-PrEP among commercial minibus drivers in Nigeria by engaging commercial minibus drivers as peer educators/research facilitators.

PI_NAMEs: CONSERVE, DONALDSON  (contact);NWAOZURU, UCHEOMA CATHERINE

PROGRAM_OFFICER_NAME: DEJLI, JAMAL

PROJECT_TERMS: Address;Adherence;Adolescent;Africa;African;AIDS prevention;antiretroviral therapy;Area;arm;Awareness;Caring;Characteristics;Clinical;Collaborations;Communities;community engaged approach;comparative effectiveness;comparison intervention;Consolidated Framework for Implementation Research;cost effectiveness;cost estimate;Country;Data;Development;Diagnostic Reagent Kits;Effectiveness;effectiveness evaluation;effectiveness/implementation design;effectiveness/implementation study;effectiveness/implementation trial;Evaluation;follow-up;Friends;Funding;Guidelines;Health care facility;Health Services;high risk;high risk men;HIV;HIV Seronegativity;HIV Seropositivity;Home;Hour;Human immunodeficiency virus test;Hybrids;implementation determinants;implementation process;implementation science;Individual;Injectable;innovation;Interdisciplinary Study;Intervention;Intervention Trial;Lesotho;Letters;Leukocyte Adherence Inhibition Test;Local Government;Malawi;male;Mediating;Mediator;Medical Research;men;Mission;Modality;National Institute of Allergy and Infectious Disease;Nature;Nigeria;Oral;Outcome;Participant;peer;Persons;Pharmaceutical Preparations;pill;pre-exposure prophylaxis;preference;Prevalence;prevent;Prevention;prevention service;primary outcome;Privatization;programs;Randomized;Randomized, Controlled Trials;Research;Risk;RNA;Role;Sampling;scale up;secondary outcome;self testing;Sex Behavior;Sexual Partners;Social Network;South Africa;standard of care;Surveys;Teenagers;Testing;testing services;therapy adherence;therapy design;Time;tool;treatment services;trial design;United States National Institutes of Health;uptake;Viral;willingness;Work;World Health Organization;Youth;Zambia;Zimbabwe

PROJECT_TITLE: Innovative Tools to Expand HIV Self-Testing and Long-Acting Injectables for HIV Treatment and Prevention Among Commercial Minibus Drivers (I-TEST LAIs)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-K (02)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: NEW YORK BLOOD CENTER

PHR: Project Narrative The study purpose is to examine how geographic mobility impacts HIV prevention and care among Latino gay, bisexual, and other men who have sex with men (GBMSM) in New York City. The study will involve brief surveys, interviews, and mapping of travel events. This study will provide information on how to design programs to improve HIV and pre-exposure prophylaxis (PrEP) care among immigrant and migrant Latino GBMSM who are mobile.

PI_NAMEs: DIAZ, JOSE E;TIEU, HONG VAN NHU (contact)

PROGRAM_OFFICER_NAME: STENSON, ANAIS FERN

PROJECT_TERMS: Address;Adherence;adherence rate;Affect;AIDS prevention;antiretroviral therapy;barrier to care;Birth;Bisexual;care outcomes;care systems;Caring;Central America;Communities;Complex;Country;cultural competence;Data;design;Destinations;Diagnosis;Dominican Republic;Economics;Ensure;Epidemic;Equity;Event;Exhibits;experience;food insecurity;forgetting;Frequencies;Funding;Future;Gays;Geography;Health Services Accessibility;Heterogeneity;Hispanic;HIV;HIV diagnosis;HIV Seronegativity;Homophobia;Human immunodeficiency virus test;Immigrant;Immigration;improved;Individual;innovation;International Migrations;Intervention;Interview;Knowledge;Language;Latino;Latino Population;Link;Location;Maps;men who have sex with men;Mexico;Migrant;Monitor;multidisciplinary;New York City;novel;Outcome;Pattern;Persons;Pharmaceutical Preparations;Population;Poverty;pre-exposure prophylaxis;prevention service;programs;Public Health;Puerto Rico;racial discrimination;Reporting;Research;Sampling;Seasons;Security;segregation;Services;Sex Behavior;sexual minority group;social stigma;South America;Spanish;structural determinants;Subgroup;support network;Surveys;therapy adherence;therapy design;transmission process;Trauma;Travel;trend;Underinsured;Uninsured;uptake;urban area;Viral;Viral Load result;Vulnerable Populations;Work

PROJECT_TITLE: Impact of geographic mobility on PrEP and HIV care outcomes among Latino gay, bisexual and other men who have sex with men


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Rehabilitation;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Older women represent an increasing proportion of persons living with HIV in the United States. This research will identify how experiences of stigma impact cognitive function and the extent to which social support can serve as a protective factor against the adverse impacts of stigma. Findings from this study will inform best practices for HIV care and management by potentially highlighting modifiable risk factors (HIV and gender based stigma) that could be targeted to offset cognitive decline among this population.

PI_NAMEs: VU, THI  (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Activities of Daily Living;Address;Adherence;Adult women;Affect;Age;age effect;Aging;antiretroviral therapy;Anxiety;Behavior;care seeking;caregiving;Caring;Clinical;Cognition;Cognitive;cognitive change;cognitive function;cognitive performance;cognitive testing;Communities;comorbidity;Continuity of Patient Care;Cross-Sectional Studies;Data;depressive symptoms;design;Diagnosis;disability;Discrimination;Drug usage;Early identification;Enrollment;experience;Family;Financial Hardship;Friends;Gender;gender difference;General Population;Health;Health Personnel;Health Promotion;High Prevalence;HIV;HIV/AIDS;Impaired cognition;improved;Individual;insight;Intervention;intimate partner violence;Knowledge;late life;Link;Loneliness;longitudinal analysis;male;men;Mental Depression;Modeling;modifiable risk;mortality;Neurocognitive;Neurocognitive Deficit;Neurodegenerative Disorders;neuropsychiatry;older adult;older men;older women;Outcome;Participant;Patient Self-Report;Persons;Population;Prospective cohort;Prospective, cohort study;protective factors;psychosocial;Psychosocial Factor;Quality of life;Questionnaires;Reporting;Research;resilience;Resources;Risk;Risk Factors;Role;Sample Size;Sampling;Series;sex;Sexual Health;Shame;Site;social exclusion;social expectations;social stigma;Social support;Standardization;Stigmatization;Surveys;Testing;United States;Violence;Woman;Women's cohort;Work;young adult

PROJECT_TITLE: Influences of Stigma and Social Support on Cognitive Function Among Older Women Living with Human Immunodeficiency Virus


ADMINISTERING_IC: HD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: Newark

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE (from most recent renewal) This very successful and innovative training program fuses two independent training programs, a professional Doctorate in Physical Therapy (DPT) and the PhD in Biomechanics and Movement Sciences. The goal of this training program is to train students with the greatest potential to become outstanding research scientists in the field of physical rehabilitation. The program attracts outstanding students and has trained some of our countries most promising rehabilitation clinician scientists.

PI_NAMEs: REISMAN, DARCY S. (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Doctor of Philosophy;pre-doctoral;Training Programs

PROJECT_TITLE: PT/PHD Predoctoral Training Program Diversity Supplement


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: DREXEL UNIVERSITY

PHR: PROJECT NARRATIVE HIV infection and cocaine act independently and in tandem to dysregulate the glucocorticoid system following stress, which may contribute to stress-induced relapse. Astrocytes have been implicated in relapse-like behaviors and are particularly sensitive to stress-induced modulation of the glucocorticoid system. The proposed project will assess the interaction of EcoHIV infection and cocaine exposure in the regulation of the astrocytic glucocorticoid system and stress-induced reinstatement of cocaine seeking.

PI_NAMEs: GIACOMETTI, LAURA L (contact)

PROGRAM_OFFICER_NAME: MCCLURE-BEGLEY, TRISTAN DAVID

PROJECT_TERMS: acute stress;Adherence;Adrenal gland hypofunction;Adrenal Glands;Affect;Animal Model;antiretroviral therapy;Astrocytes;Attenuated;attenuation;Automobile Driving;Behavior;biological adaptation to stress;Blood;Calcium;Calcium Signaling;Chronic;Cocaine;Cocaine Dependence;cocaine exposure;cocaine seeking;cocaine use;Cocaine withdrawal;comorbidity;conditioned place preference;Corticosterone;craving;Cues;Data;Disease Outcome;Disease Progression;Disease susceptibility;Drug usage;Exhibits;experimental study;Exposure to;Extinction;Female;Food;Functional disorder;General Population;Genetic;Glucocorticoid Receptor;Glucocorticoids;HIV;HIV Infections;HIV-1;Homeostasis;Homologous Gene;Hormonal;Hormones;Hydrocortisone;Immunohistochemistry;Impairment;Infection;Knowledge;Label;male;Mediator;Modeling;Mus;Nucleus Accumbens;Outcome;perceived stress;Perfusion;Persons;Plasma;Progesterone;protein expression;Proteins;receptor expression;Recording of previous events;Regulation;Relapse;relapse prevention;response;Rewards;Rodent;Rodent Model;Saline;Serum;sex;Signal Transduction;Stress;stress reduction;stressor;Substance Use Disorder;Swimming;System;tat Protein;Testing;therapeutic development;therapeutically effective;Training;Transgenic Organisms;Virion;Virus Diseases;Withdrawal

PROJECT_TITLE: HIV effects on astrocytic regulation of stress-induced cocaine reinstatement


NIH_SPENDING_CATS: Biotechnology;Breastfeeding, Lactation and Breast Milk;HIV/AIDS;Immunization;Infectious Diseases;Pediatric;Pediatric - AIDS;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: NORFOLK

ORG_NAME: OLD DOMINION UNIVERSITY

PHR: PROJECT NARRATIVE Although significant progress has been made in reducing the number of children living with HIV these past few decades, mother to baby HIV transmission through breastfeeding remains unacceptably high and is a key contributor to the continuing higher rate of infections. We will fabricate, characterize, and preclinically assess microneedle skin patches containing three broadly neutralizing antibodies for protection against HIV infection, and establish proof-of-concept through plasma and fluid antibody levels and efficacy testing in newborn macaques. This project will demonstrate the potential of a user-friendly skin patch formulation to accomplish minimally invasive passive immunization of newborns with robust doses of multiple broadly neutralizing antibodies for HIV prevention during breastfeeding.

PI_NAMEs: DONCEL, GUSTAVO F. (contact);NGUYEN, THANH

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adherence;Adult;Adverse effects;AIDS prevention;Animal Model;Animals;Anti-Retroviral Agents;Antibodies;Antibody-mediated protection;antiretroviral therapy;Breast Feeding;Breastfed infant;Cessation of life;Characteristics;Child;Childhood;Circulation;Clinic;clinical development;Clinical Trials;Cold Chains;Colorectal;Data;Dermal;design;Development;Dose;Drug Kinetics;Drug or chemical Tissue Distribution;efficacy evaluation;efficacy testing;experience;Exposure to;fabrication;follow-up;Formulation;Goals;Health;Healthcare Systems;HIV;HIV Infections;HIV-1;Immune response;Immunity;Immunoglobulins;In Vitro;in vivo;in vivo evaluation;Individual;Infant;Infection;infection rate;Infusion procedures;Injectable;Injections;innovation;Investigation;irritation;Kinetics;Lead;Liquid substance;Macaca;Macaca mulatta;manufacture;manufacturing process;Measures;mechanical properties;Methods;minimally invasive;Mother-to-child HIV transmission;Mothers;Mucous Membrane;Needles;Neonatal;neonate;Neutralization Tests;neutralizing antibody;Nevirapine;Newborn Infant;novel;Oral;Oryctolagus cuniculus;Pain;Passive Immunization;pediatric human immunodeficiency virus infection;Perinatal;Perinatal Exposure;perinatal HIV;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Plasma;postnatal;Powder dose form;pre-clinical assessment;preclinical evaluation;prevent;Prevention;Process;prophylactic;Prophylactic treatment;prototype;Rattus;Regimen;Resource-limited setting;Safety;safety assessment;safety study;Sampling;Serum;side effect;simian human immunodeficiency virus;Site;Skin;skin patch;Structure;Swab;Technology;Testing;Time;Tissues;transmission process;Transportation;user-friendly;Viral Load result;Vulnerable Populations

PROJECT_TITLE: Advancing Multi-bNAbs Microneedle Patch Technology For HIV-1 Prevention in Breastfeeding Infants.


ORG_CITY: TALLAHASSEE

ORG_DEPT: BIOLOGY

ORG_NAME: FLORIDA STATE UNIVERSITY

PHR: Project Narrative HIV-1 infection establishes a stable provirus in the human genome through the process of integration of its viral DNA into actively transcribing genes. The mechanisms of how HIV-1 finds genes for its integration remain unclear. This project will use cutting-edge imaging, integration site mapping and genomics approach to uncover HIV-1 transport mechanisms in the nucleus towards its integration sites, and advance our understanding of virus cell biology, which is of high public health significance.

PI_NAMEs: FRANCIS, ASHWANTH CHRISTOPHER (contact)

PROJECT_TERMS: Actins;Active Biological Transport;Architecture;Arginine;Automobile Driving;Bass;Binding;Biological Assay;Capsid;CD4 Positive T Lymphocytes;cell growth regulation;Cell Line;Cell model;Cell Nucleus;cell type;Cells;Cellular biology;cellular targeting;Charge;Chromatin;Collaborations;Colorado;Complementary DNA;Complex;Data;Dependence;Disease;DNA;DNA Integration;epigenomics;experimental study;Filament;Foundations;Genes;Genetic Transcription;Genome;Genomic approach;Genomics;Glycols;Grant;Hexanes;HIV;HIV-1;Human Genome;Image;imaging approach;In Vitro;Individual;Infection;insight;Integration Host Factors;integration site;Karyopherins;Lamins;Length;Liquid substance;live cell imaging;Macrophage;Maps;Mass Spectrum Analysis;Mediating;Membrane;Microfilaments;monocyte;Motion;Movement;new technology;novel;Nuclear;Nuclear Envelope;Nuclear Import;Nuclear Pore;Nuclear Pore Complex;Nuclear Pore Complex Proteins;nucleocytoplasmic transport;Nucleoplasm;Nucleosomes;Organelles;Peripheral;Phase;Play;Polyadenylation;Positioning Attribute;prion-like;Process;Productivity;Proteins;Proviruses;Public Health;Recombinants;recruit;release factor;Resolution;response;Reverse Transcription;RNA;Role;Seminal;Serine;Signal Transduction;Site;Small Interfering RNA;small molecule;small molecule inhibitor;SRSF2 gene;trafficking;Transport Process;Tube;Viral;viral DNA;Viral Genes;Viral Genome;Viral Reverse Transcription;Virus;Virus Diseases;virus host interaction;Virus Replication;Visualization

PROJECT_TITLE: Elucidating HIV-1 nuclear trafficking to integration sites


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Patient Safety;Physical Rehabilitation;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Despite strong evidence for integrative non-pharmacologic treatments for chronic pain, only 3% of patients have reliable access with minority and low-income populations affected more than others. Even when access is available, striking health care disparities exist often driven by provider biases and/or systemic or environmental barriers. The INSPIRE project creates an integrative, evidence-based digital system that delivers cognitive-behavioral therapy, physical therapy, mindfulness meditation, and personalized pain coaching using a smartphone app, telehealth visits, and primary care coordination using the electronic health record. Intervention features and trilingual materials will be collaboratively developed with the Black/African- American, Chinese, and Latinx communities then validated in a real world randomized trial.

PI_NAMEs: SATTERFIELD, JASON M (contact)

PROGRAM_OFFICER_NAME: SANKAR, CHERYSE A

PROJECT_TERMS: Acceleration;acceptability and feasibility;Address;Affect;African American;Anxiety;arm;Awareness;behavioral health;Black race;care coordination;Caring;Chinese;chronic pain;chronic pain management;chronic pain patient;Clinical;clinically relevant;Cognitive Therapy;Collection;Common Data Element;Communities;community engagement;comorbidity;dashboard;Data Collection;Decision Making;design;Development;digital;digital health;digital tool;Disparity;dissemination strategy;Documentation;Education;Educational Intervention;Electronic Health Record;Equity;ethnic minority;evidence base;Evidence based intervention;flexibility;Focus Groups;Future;Health;Health Care Costs;health care disparity;health disparity;health disparity populations;health literacy;Health Personnel;Health Services Accessibility;Healthcare;high standard;human centered design;Hybrids;implementation evaluation;implementation outcomes;implementation strategy;Improve Access;improved;Individual;informant;Intake;Integrative Therapy;Intervention;Interview;Knowledge;Language;Latinx;Limited English Proficiency;Linguistics;literacy;Low Income Population;marginalization;Measures;Mediator;Medical;medical specialties;Mental Depression;Methods;mindfulness;mindfulness meditation;Minority;mobile application;Modeling;Morbidity - disease rate;Motivation;Multilingualism;Nonpharmacologic Therapy;Opioid;opioid use disorder;Outcome;overdose death;Pain;Pain intensity;Pain interference;pain outcome;pain reduction;pain symptom;Participant;participant retention;Pathway interactions;Patient Compliance;Patient Isolation;Patient Outcomes Assessments;Patient Recruitments;Patients;Persons;Phase;Physical therapy;Pilot Projects;pilot test;prescription opioid;Primary Care;primary care clinician;primary outcome;Process;process evaluation;programs;Protocols documentation;Provider;provider networks;psychiatric comorbidity;psychologic;Quality of Care;Quality of life;racial minority;randomized trial;Records;Reporting;Risk;satisfaction;secondary outcome;Self Efficacy;smartphone application;social;Social isolation;Social Network;social stigma;standard of care;Stigmatization;substance use;Substance Use Disorder;success;Support Groups;Surveys;System;telehealth;Testing;theories;Time;tool;treatment as usual;treatment effect;treatment program;Trust;tutoring;Validation;Visit;Visualization

PROJECT_TITLE: Integrating Nonpharmacologic Strategies for Pain with Inclusion, Respect, and Equity (INSPIRE): Tailored digital tools, telehealth coaching, and primary care coordination


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Methamphetamine;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

PHR: Project Narrative This project will be among the first to develop and assess the feasibility, acceptability, and preliminary efficacy of a novel behavioral economic informed intervention to address PrEP nonadherence, methamphetamine use and HIV sexual risk behaviors in a sample of sexual minority men – a group disproportionately affected by HIV in the United States. Episodic Future Thinking, a novel behavioral economic informed intervention will be delivered over six months via a smartphone app. Findings from this study will provide preliminary data and lay the groundwork for conducting a larger-scale trial to formally determine efficacy.

PI_NAMEs: OKAFOR, CHUKWUEMEKA NKEMAKONAM (contact);YOON, JIN HO

PROGRAM_OFFICER_NAME: FOSTER, KATRINA L

PROJECT_TERMS: acceptability and feasibility;Accounting;Address;Adherence;adherence rate;Affect;AIDS prevention;arm;Behavior;behavioral economics;Blood;Cellular Phone;condomless anal sex;condoms;consistent condom use;cost;Counseling;Data;Decision Making;Development;Diabetes Mellitus;Diagnosis;discounting;Dose;Drug Screening;Drug usage;Dryness;Educational Intervention;efficacy evaluation;efficacy testing;Elements;Enrollment;Epidemic;Event;Exhibits;experience;Feedback;formative assessment;Future;Goals;Health behavior;HIV;HIV diagnosis;HIV Infections;HIV risk;improved;Individual;Intervention;Interview;Link;medication compliance;Methamphetamine;methamphetamine use;Methods;Motivation;Needle Sharing;novel;Oral;Outcome;Outcome Measure;Participant;Patient Self-Report;Personal Satisfaction;Persons;Pharmaceutical Preparations;Phase;pilot test;preference;prevent;primary outcome;Process;prophylactic;Protocols documentation;Randomized;Randomized, Controlled Trials;recruit;reduced substance use;Rewards;Risk;Risk Behaviors;Safe Sex;Sampling;sex;sexual minority men;sexual risk behavior;Signal Transduction;smartphone application;Spottings;Structure;substance use;System;Testing;Thinking;Time;tool;transmission process;trial comparing;United States;Urine;usability

PROJECT_TITLE: Development of a behavioral economic Intervention to improve HIV-related behaviors among sexual minority men.


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE This proposal is an innovative multilevel intervention that combines a media campaign and peer-based strategy, informed by community engagement and social network analysis, to increase PrEP awareness and use among young Latino sexual minority men. This research will lead to a culturally and developmentally tailored intervention that can serve as a model for HIV prevention efforts in marginalized youth and young adults.

PI_NAMEs: SHAH, HARITA  (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Address;Adult;Age;AIDS prevention;Award;Awareness;barrier to care;behavior change;bilingualism;Caring;Characteristics;Chicago;Communities;community based participatory research;community engagement;Consolidated Framework for Implementation Research;Decision Making;Development;Disparity;effectiveness study;Epidemic;Event;experience;Family;Feedback;Future;Goals;health disparity;Health Services Research;HIV;HIV diagnosis;HIV disparities;Human immunodeficiency virus test;Immigrant;implementation determinants;implementation evaluation;implementation framework;implementation outcomes;implementation science;improved;Incidence;Individual;Influentials;Injections;innovation;Insurance;Internal Medicine;Intervention;Interview;K-Series Research Career Programs;Language;Latino;Latino Population;Latinx;Lead;Limited English Proficiency;Literature;marginalization;marginalized community;marginalized population;Media Campaign;member;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Modeling;Oral;outreach;Pathway Analysis;Pediatrics;peer;peer networks;Persons;Physicians;pilot test;Population;population health;Positioning Attribute;pre-exposure prophylaxis;prevent;preventive intervention;Production;queer;racism;Randomized, Controlled Trials;Recommendation;recruit;Research;Research Personnel;Sexual and Gender Minorities;sexual minority men;Shapes;skills;social;social media;Social Network;social network intervention;social stigma;Spanish;Structure;Surveys;Tablets;Testing;therapy development;Training;uptake;web site;Work;young adult;Youth

PROJECT_TITLE: Leveraging Social Networks to Promote PrEP among Young Latino Sexual Minority Men


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE The remarkable persistence of the HIV latent reservoir in people on antiretroviral therapy is due to the proliferation of infected CD4+ T cells. However, the degree to which homeostatic proliferation versus antigen- driven proliferation maintains the reservoir is difficult to discern because of undersampling of prior HIV provirus sequencing datasets. Here, we will generate deeper near-full length HIV provirus sequencing datasets than have been available in the past, fully characterize the clonality distributions of intact and defective proviruses during antiretroviral therapy, and construct models to estimate the relative contributions of antigen-driven and homeostatic proliferation to the maintenance of the HIV latent reservoir.

PI_NAMEs: ANTAR, ANNUKKA AIDA ROSE (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Antigens;antiretroviral therapy;Blood;CD4 Positive T Lymphocytes;Cell Lineage;Cell Proliferation;Cells;Circulation;Clonality;Clone Cells;cytokine;Data;Data Set;deep sequencing;design;Deuterium Oxide;experimental study;Future;Genes;Genetic Transcription;Genome;Growth;Half-Life;HIV;HIV Infections;Human;in vivo;Kinetics;Knowledge;Label;latent HIV reservoir;Laws;Length;Maintenance;Malignant Neoplasms;mathematical model;Mediating;member;memory CD4 T lymphocyte;Modeling;Myelogenous;Oncogenes;Outcome;Peripheral;personalized therapeutic;Persons;PHEMX gene;Phenotype;Proliferating;Provirus Integration;Proviruses;Publishing;Rest;Sampling;Stimulus;T-Cell Proliferation;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte Subsets;Tail;Techniques;Testing;Therapeutic;Tissues;vaccine trial;Work

PROJECT_TITLE: Deep sequencing of the HIV latent reservoir to discern mechanisms of clonal proliferation and HIV persistence


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurosciences;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Narrative By utilizing rhesus macaque model of HIV/SIV infection, our proposal will address whether sex differences play a role in establishing and maintaining HIV/SIV reservoirs with and without opioids in diverse tissues, including CNS.

PI_NAMEs: BYRAREDDY, SIDDAPPA N (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Address;Adherence;Affect;Age;Animals;Anti-Retroviral Agents;Anti-viral Response;antiretroviral therapy;ATAC-seq;Biological Assay;Biological Factors;Brain;Brain region;Cell Lineage;Cell Nucleus;Cells;Central Nervous System;Chromatin;Chronic;chronic pain;Clinical;Control Animal;craving;Data;Dependence;design;DNA Methylation;Drug Kinetics;Endocrine;Environment;Estrogen Receptors;Etiology;Exhibits;experience;Exposure to;Female;Genetic Transcription;Goals;HIV;HIV Infections;Immune response;Immunologics;Immunology;Immunology procedure;Individual;Infection;insight;integration site;ITGAM gene;Kinetics;Knowledge;Laboratories;Location;lymph nodes;Lymphoid;Lymphoid Tissue;Macaca;Macaca mulatta;Maintenance;male;mathematical model;Mediating;men;Metabolic;methylation pattern;Microglia;Modeling;models and simulation;Molecular;Morphine;mu opioid receptors;Myelogenous;Myeloid Cells;Needle Sharing;novel therapeutics;Opiate Addiction;Opioid;opioid abuse;opioid use;Outcome;Pathogenesis;Peripheral;Peripheral Blood Mononuclear Cell;Persons;Pharmacology;Play;polysubstance abuse;Predisposition;prescription opioid;Process;Reagent;Receptor Signaling;Recrudescences;Rectum;Relapse;Reporting;Research;response;Role;Series;sex;Sex Differences;Sex Factors;SIV;social culture;Socioeconomic Factors;stem;Structure;Substance abuse problem;substance use;Substance Use Disorder;System;Techniques;Tissue Sample;Tissues;Variant;Viral;Viral Load result;Viral reservoir;Virus;Woman

PROJECT_TITLE: Sex differences in modulating HIV/SIV reservoirs in the context of opioids


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: GALVESTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: NARRATIVE The human immune deficiency virus (HIV) affects 38 million people worldwide, and 50% of the people living with HIV (PLWH) show signs of HIV-associated neurocognitive disorder (HAND). Despite effective antiretroviral treatment (ART), viral reservoirs are resistant to treatment and are the major contributors to the cognitive decline in PLWH. We will examine the mechanisms of TNT formation and their contribution to the transfer of viral material and neurotoxic proteins during chronic HIV CNS infection.

PI_NAMEs: VALDEBENITO-SILVA, SILVANA A (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: acute infection;Address;Affect;Amyloid beta-Protein;antiretroviral therapy;Area;Award;Binding;Blood brain barrier dysfunction;Brain;career;Cell Communication;cell motility;Cell Surface Extensions;Cells;Central Nervous System;Central Nervous System Infections;Chronic;clinically relevant;Communicable Diseases;Data;Death Rate;design;Development;Disease;endoplasmic reticulum stress;Equipment;Event;Faculty;fitness;Foundations;Funding;Future;Generations;glial activation;Glioblastoma;Goals;Heat shock proteins;high reward;high risk;HIV;HIV Infections;HIV-1;HIV-associated neurocognitive disorder;Human;Immune;Immune Evasion;Immune system;immunodeficiency;Impaired cognition;Impairment;in vivo;Individual;Infection;Inflammation;innovation;Institution;Interruption;Knowledge;Laboratories;Leucocytic infiltrate;life span;Malignant Neoplasms;Mediating;Mentors;meter;Mitochondria;Molecular;Nanotubes;Nerve Degeneration;Nervous System Disorder;neuroAIDS;neurocognitive disorder;Neurodegenerative Disorders;Neurons;Neurosciences;neurotoxic;neurotoxicity;neurotropic virus;novel;Organelles;Pathology;peer;Permeability;Persons;Play;Positioning Attribute;prevent;Primary Infection;Process;professor;Proliferating;protein aggregation;Proteins;Published Comment;Research;Research Personnel;Research Support;Resistance;response;RNA;RNA Binding;RNA Transport;Route;Science;Scientist;Signal Transduction;Signaling Molecule;Stress;Suggestion;System;tau Proteins;Technology;therapy resistant;Time;Tissues;tool;Toxic effect;Training;Training Support;Translating;transmission process;Treatment-related toxicity;Viral;Viral reservoir;viral RNA;virological synapse;Virus;Work

PROJECT_TITLE: Tunneling nanotubes are a novel mechanism for the propagation of HIV infection and neurodegeneration

STUDY_SECTION: NST

STUDY_SECTION_NAME: Neurological Sciences Training 3 Study Section[NST-3]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: CONSTRUCTION GRANTS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: HIV/AIDS

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PI_NAMEs: RUSSELL-LODRIGUE, KASI E (contact)

PROGRAM_OFFICER_NAME: AGGARWAL, MONIKA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Animal Experimentation;Animals;Applied Research;Area;Basic Science;Biomedical Research;Breeding;Censuses;Complement;Consensus;Dedications;design;Engineering;Ensure;Evaluation;flexibility;Funding;Future;germ free condition;Health;HIV/AIDS;Housing;Human;improved;Infrastructure;Knowledge;Macaca;Macaca mulatta;Medicine;Modeling;nonhuman primate;novel;operation;Personal Satisfaction;Primates;Production;programs;public health emergency;Reporting;Research;Research Personnel;Research Priority;Resources;Science;Scientific Advances and Accomplishments;United States National Academy of Sciences;United States National Institutes of Health;Universities;Weather

PROJECT_TITLE: SPF Rhesus Macaque Breeding Colony Expansion to Support HIV/AIDS-Related Research

STUDY_SECTION: STOD

STUDY_SECTION_NAME: Scientific and Technical Review Board on Biomedical and Behavioral Research Facilities[STOD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Innovative ideas are crucial for developing an effective HIV/AIDS vaccine. The aim of this project is to create AB toxin-based vaccines with the capability to elicit broadly neutralizing antibodies targeting the fusion peptide region of HIV-1 and capable of neutralizing Tier 2 viruses, ultimately paving the way for a protective vaccine.

PI_NAMEs: KONG, XIANGPENG  (contact)

PROGRAM_OFFICER_NAME: DANG, QUE

PROJECT_TERMS: Adjuvant;Advanced Development;Animal Model;Antibodies;Antibody Formation;Antibody Response;Antigens;Binding;Carrier Proteins;chemical conjugate;Cholera Toxin;Cholera Toxin Protomer B;Cytotoxin;design;Development;efficacy study;Engineering;env Gene Products;Epitopes;experimental study;Family;fighting;flexibility;Foundations;Future;Generations;glycosylation;Goals;HIV;HIV Envelope Protein gp120;HIV vaccine;HIV-1;HIV/AIDS;Human;Immune response;immunogenic;immunogenicity;immunoregulation;improved;innovation;Keyhole Limpet Hemocyanin;Mucous Membrane;Mus;nanoparticle;neutralizing antibody;next generation;novel;Oryctolagus cuniculus;pathogen;Penetration;Peptide Vaccines;Peptides;Pertussis Toxin;Pilot Projects;Polysaccharides;Property;protein aminoacid sequence;Protomer;Recombinants;Regimen;Resources;response;scaffold;Shiga Toxin;Site;stem;Structure;Testing;tool;Toxin;vaccine candidate;vaccine development;Vaccines;Variant;Vibrio cholerae;Virus

PROJECT_TITLE: Eliciting Broadly Neutralizing Antibody Responses against HIV-1 Fusion Peptide Epitope by AB Toxin B Subunit-Based Immunogens