NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_CITY: MILWAUKEE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE In order to address the high rates of overweight/ obesity in Puerto Rican men, we propose a proof-of-concept study to determine if a telehealth intervention, tailored to target Puerto Rican men of varying levels of acculturation, is acceptable and feasible, and can achieve clinically meaningful weight loss. The “TeleSalud Healthy Eating, Physical Activity, and Sedentary Behavior Intervention” (TeleSalud HE-PA/SB) will consist of 4 months of twice-weekly classes on increasing HE and PA and decreasing SB, followed by a 4-month HE, PA and SB maintenance intervention. This intervention will be compared to the “TeleSalud General Health” (GH) intervention, consisting of 4 months of twice weekly telehealth classes on general health issues, followed by a 4-month General Health intervention.

PI_NAMEs: SANCHEZ-JOHNSEN, LISA  (contact)

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: Accelerometer;acceptability and feasibility;Acculturation;Address;Adherence;Adolescent;Affect;Behavior;Behavior Therapy;behavioral health;Belief;Body mass index;Body Weight decreased;Calories;cardiovascular disorder risk;Categories;Chicago;Clinical;Clinical Trials;clinically significant;community advisory board;Community Health;culturally appropriate intervention;Data;Diet;Dietary intake;Disease;Eating;Energy Intake;Equipment;ethnic minority;Ethnic Origin;Exercise;expectation;feasibility testing;Food;Foundations;Frequencies;fruits and vegetables;Funding;Future;Health;Health behavior;health equity;Healthy Eating;High Prevalence;high risk;Hispanic;Hispanic Community Health Study/Study of Latinos;Hour;hypercholesterolemia;Individual;Intake;International;Intervention;Latino;Latino Population;lifestyle factors;lifestyle intervention;low socioeconomic status;Maintenance;Measures;men;Metabolic;Mexican;Mission;Modality;moderate-to-vigorous physical activity;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity risk;obesity treatment;Outcome;Overweight;Physical activity;physical inactivity;Population;Prevalence;Process Measure;promoter;Public Health;Publishing;Puerto Rican;Questionnaires;Randomized;Recommendation;recruit;response;Rural Community;satisfaction;saturated fat;sedentary lifestyle;Self Efficacy;social cognitive theory;Social support;Specialist;Subgroup;Technology;telehealth;translational medicine;trend;tv watching;United States National Institutes of Health;Universities;Weight;weight loss intervention

PROJECT_TITLE: Puerto Rican Obesity Intervention for Men

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: OD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics

ORG_CITY: CAMBRIDGE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE  The goal of the proposed research is to produce an integrative study of the epigenetic process of caste development in ants. The research will advance our understanding of this cell-type-like differentiation process using three complementary scientific approaches: laboratory, field, and museum studies. Caste is one of the most exaggerated and robust examples of phenotypic plasticity in nature, and this research important advances in understanding the mechanisms and evolution of animal development.

PI_NAMEs: TRIBLE, WARING  (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TITLE: The Molecular Basis of Caste Development and Evolution in Ants

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-H(70)R]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Clinical Research;Lung;Pediatric;Prevention

ORG_CITY: ORANGE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: CHAPMAN UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Adolescents with asthma have alarmingly low medication adherence rates and thus novel approaches to increasing medication adherence and subsequent asthma health are needed. The proposed research will examine how momentary-positive-affect prospectively relates to adherence and stress, and subsequent asthma health in adolescents with moderate to severe persistent asthma. Understanding these associations at the momentary level will help inform future positive affect interventions to treat asthma in adolescents.

PI_NAMEs: JENKINS, BROOKE  (contact)

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: Adherence;adherence rate;Adolescence;Adolescent;Adrenal Cortex Hormones;adverse outcome;Affect;Age;Area;Asthma;Behavior Therapy;Caregivers;Caring;Childhood;Childhood Asthma;Chronic Disease;Clinic;Clinical;Compensation;Data Collection;design;Development;Diagnosis;Effectiveness of Interventions;Emotions;Ensure;experience;follow-up;Foundations;Funding;Future;Guidelines;Happiness;Health;Health behavior;Healthcare;improved;Individual;Inhalation;innovation;Intervention;Investigation;Life;Literature;Measures;Medical;medication compliance;Modeling;Nature;novel strategies;Outcome;Participant;participant retention;Patient Recruitments;Peer Review;Persons;Pharmaceutical Preparations;Play;Preventive;primary caregiver;prospective;Psychology;Recommendation;recruit;Research;Research Personnel;Role;Schools;Seasons;Self Management;skills;Social Network;Stress;stress management;stress reduction;Surveys;Testing;Time;trait;United States National Institutes of Health;Work

PROJECT_TITLE: Positive Affect and Pediatric Asthma: An Innovative Positive Psychology Model to Improve Asthma Management and Health

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences;Pediatric

ORG_CITY: COLLEGE STATION

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

ORG_STATE: TX

PHR: Project Narrative This project will investigate the efficacy and safety of the synthetic neurosteroid ganaxolone in reducing seizures and brain injury that result from exposure to nerve agents in pediatric and aged rat models. This proposal will address a data gap concerning unique vulnerability of children and the elderly civilians to nerve agents. It will help developing a specific pediatric anticonvulsant antidote for nerve agent exposures.

PI_NAMEs: REDDY, DOODIPALA SAMBA (contact)

PROGRAM_OFFICER_NAME: SPRIGGS, SHARDELL M

PROJECT_TERMS: Acute;Address;Adult;Age;aged;aging population;Amendment;animal rule;Anticonvulsants;Antidotes;Atropine;attenuation;Behavior;behavior test;Benzodiazepines;Biological;Brain;Brain Injuries;Child;Childhood;Cholinergic Agents;Chronic;Clinical;Clinical Trials;Consultations;Data;design;Development;Dose;Drug Kinetics;efficacy evaluation;efficacy testing;efficacy validation;Elderly;Epilepsy;Event;Exhibits;experimental study;Exposure to;FDA approved;Female;Formulation;GABA-A Receptor;ganaxolone;Glial Fibrillary Acidic Protein;Goals;Injections;Intoxication;Lead;lead optimization;Letters;Life;male;Mediating;medical countermeasure;Memory;Metabolic;Midazolam;Modeling;Molecular;Morbidity - disease rate;mortality;nerve agent;Nerve Degeneration;neuroinflammation;Neurologic;Neurologic Dysfunctions;Neuronal Injury;Neurons;neuropathology;neuroprotection;Neuroprotective Agents;neurosteroids;neurotoxicity;novel;novel therapeutics;organophosphate poisoning;Organophosphates;Outcome;Outcome Measure;Pathway interactions;pesticide poisoning;Pesticides;Pharmaceutical Preparations;Phase;Pilot Projects;Population;Predisposition;prevent;Prevention;primary outcome;programs;Protocols documentation;Rattus;Refractory;Regimen;Risk;Safety;safety study;Sarin;Schools;secondary outcome;Seizures;sex;Sex Differences;Soman;Special Population;Status Epilepticus;stem;success;Synapses;Testing;Therapeutic;Toxicokinetics;Treatment Effectiveness;Treatment Protocols;Validation;Women's cohort;Work

PROJECT_TITLE: Novel pediatric anticonvulsants for nerve agents


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Diabetes;Kidney Disease;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Prevention

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Non-traumatic lower extremity amputations (NLEA) in people with diabetic peripheral neuropathy have devastating consequences, most notable a 3-year mortality rate of up to 71%. The highest rate of NLEA occurs in individuals with diabetes-induced end-stage chronic kidney disease, who have marked loss of bone quantity and quality and an increase in vascular calcification due to the progression of both diabetic peripheral neuropathy and chronic kidney disease. This renewal application will extend our discoveries and test the central hypothesis that chronic kidney disease-mineral bone disorder syndrome synergistically combines with diabetic peripheral neuropathy in the bone and vascular deterioration pathway to place the diabetic neuropathic foot at the highest risk for NLEA.

PI_NAMEs: HASTINGS, MARY K (contact)

PROGRAM_OFFICER_NAME: GOROSPE, RAFAEL

PROJECT_TERMS: Affect;Age;Amputation;Aorta;Award;bench to bedside;Blood Vessels;bone;Bone Density;Bone Diseases;bone loss;bone quality;Bone remodeling;calcification;California;Chronic Kidney Failure;chronic ulcer;clinical practice;Clinical Research;clinical risk;clinically relevant;Coronary;cortical bone;Data;Death Rate;Deformity;Deterioration;Diabetes Mellitus;diabetic;Diabetic Foot;Disease Progression;disorder prevention;Early Intervention;follow-up;foot;foot bone;Foot Deformities;Fracture;Glomerular Filtration Rate;high risk;Hip region structure;Image;Impaired wound healing;Impairment;improved;Individual;inhibitor;Injury to Kidney;innovation;Intervention;Kidney Diseases;Link;Lower Extremity;Measurement;Measures;Mediating;Methods;Minerals;Monitor;Natural regeneration;Neuropathy;Osteocytes;Outcome;Participant;Pathway interactions;Perfusion;Peripheral;Peripheral Nervous System Diseases;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Porosity;Predisposing Factor;Prevention;Preventive care;Radiology Specialty;Renal function;repaired;Research;Resolution;response;Risk;Risk Factors;risk prediction;Risk Reduction;Role;San Francisco;Serum Markers;Severity of illness;sex;Site;Skeletal bone;Smoking;Smooth Muscle;Syndrome;Technology;Testing;Tissues;Translating;Trees;Type 2 diabetic;Ulcer;Universities;Vascular calcification;Washington;Weight;Work;X-Ray Computed Tomography

PROJECT_TITLE: Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) Syndrome in the Diabetic, Neuropathic Foot

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Autoimmune Disease;Celiac Disease;Clinical Research;Digestive Diseases;Nutrition;Prevention

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The proposed research will provide a molecular understanding of the mechanisms that control the activation of resident cytolytic T cells that mediate tissue destruction. Furthermore, our study will provide a knowledge base that will help with the interpretation of the outcome of clinical trials and identify appropriate treatment strategies to individual patients. It will have a significant positive impact on human health because it will help define curative and preventive strategies that have the potential to prevent tissue destruction in celiac disease. Thus, this work will directly support the NIDDK mission of developing fundamental knowledge that will help reduce the burden of human disease, and improve the health of patients with digestive disease.

PI_NAMEs: JABRI, BANA  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: adaptive immunity;Adult;Affect;Antibodies;Architecture;Atrophic;Biopsy;CD4 Positive T Lymphocytes;CD8B1 gene;Celiac Disease;Cell Compartmentation;cell motility;Cells;chemokine;Clinical;Clinical Trials;Complex;cytokine;cytotoxic;Cytotoxic T-Lymphocytes;Data;Development;dietary;Digestive System Disorders;Disease;Effector Cell;Epithelial Cells;Flow Cytometry;Funding;Genetic Transcription;Gluten;Gluten-free diet;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Health;Heterogeneity;high dimensionality;high risk;HLA-DQ2;HLA-DQ8 antigen;Human;human disease;immune modulating agents;Immunity;Immunology;immunopathology;improved;Individual;individual patient;Inflammatory;interest;Interferon Type II;Interleukin-15;intestinal epithelium;Intestines;intraepithelial;Killer Cells;Knowledge;knowledge base;Lamina Propria;Licensing;Lymphocyte;Lymphocyte Activation;Mediating;MHC Class I Genes;migration;Mission;Molecular;Morphology;mouse model;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Natural Immunity;new therapeutic target;novel therapeutic intervention;novel therapeutics;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Phenotype;Population;predictive marker;prevent;Prevention strategy;Prognostic Marker;programs;Proxy;recruit;Research;Resolution;Role;Signal Transduction;single cell technology;single-cell RNA sequencing;Sphingosine-1-Phosphate Receptor;Stress;Subgroup;SYK gene;T-Lymphocyte;Tissue Transglutaminase Antibodies;Tissues;TNF gene;transcriptome sequencing;treatment strategy;Up-Regulation;Villous Atrophy;Villus;Work;γδ T cells

PROJECT_TITLE: Innate and adaptive immunity in celiac disease

STUDY_SECTION: GMPB

STUDY_SECTION_NAME: Gastrointestinal Mucosal Pathobiology Study Section[GMPB]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety;Physical Activity;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE Chemotherapy for primary breast cancer causes significant declines in cardiorespiratory fitness (CRF) predisposing patients to increased symptom burden and increased risk of morbidity and mortality from cancer and non-cancer conditions. We propose to investigate the effects of flexible and response-adapted aerobic training (AT) on CRF response rate in patients with primary breast cancer. Results from this investigation will identify the AT regimen that maximizes CRF response rate with potential translational value to clinical cancer care.

PI_NAMEs: SCOTT, JESSICA  (contact)

PROGRAM_OFFICER_NAME: BERRIGAN, DAVID

PROJECT_TERMS: Address;Adherence;Adverse event;Aerobic;Aerobic Exercise;Attenuated;attenuation;Biometry;Breast Cancer Patient;Breast Oncology;cancer care;Cancer Etiology;cancer initiation;cancer therapy;Cardiopulmonary;cardiorespiratory fitness;chemotherapy;Clinical;clinical care;clinical implementation;Common Terminology Criteria for Adverse Events;conventional dosing;Data;design;digital;Dose;efficacy evaluation;Ensure;Exercise;exercise intensity;Exercise Test;flexibility;Frequencies;Impairment;improved;Individual;instrument;Investigation;Knowledge;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;Memorial Sloan-Kettering Cancer Center;Morbidity - disease rate;mortality;multidisciplinary;Newly Diagnosed;Oncology;Oxygen Consumption;patient oriented;Patient Outcomes Assessments;Patient Schedules;Patients;Pharmaceutical Preparations;Phase;Population;primary endpoint;Qualifying;Quality of life;Random Allocation;Randomized;randomized trial;Recovery;Regimen;Research;Research Personnel;response;Risk;Safety;Schedule;secondary endpoint;Severities;Structure;Symptom Burden;Testing;translational potential;Translations;treadmill;treatment adherence;treatment as usual;Treatment Efficacy;trial comparing;Walking;Work

PROJECT_TITLE: Flexible versus Standard Aerobic Training Dosing in Primary Breast Cancer: A Randomized and Response-Adapted Trial


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer

ORG_CITY: LOS ANGELES

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Cancer remains the top killer of adults under 85 worldwide, but recent advances that unleash the power of the immune system against tumors has shown impressive progress against many forms of intractable cancer, necessitating the advanced training of research specialists at the interface of oncology and immunology. The UCLA Tumor Immunology Training Program (TITP) is dedicated to mentored, interdisciplinary team-based training of a new generation of academic and industry leaders in basic, translational, and clinical research in tumor immunology. By deploying facilities and resources of a renowned immunotherapy trials epicenter that includes the NCI-designated Jonsson Comprehensive Cancer Center and the Parker Institute for Cancer Immunotherapy, we aim to fulfill this training mission while uncovering basic principles in host-tumor interactions and developing next-generation therapies based in fundamental tumor immunology for the betterment of cancer patients and their families.

PI_NAMEs: DUBINETT, STEVEN M.;TEITELL, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TITLE: UCLA Tumor Immunology Institutional Training Grant


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health;Telehealth

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: PROJECT NARRATIVE Nigerian sexual minority men (SMM) have high rates of HIV infection and pre-exposure prophylaxis (PrEP) uptake remains low. This project will investigate how a telehealth intervention might help improve PrEP knowledge, uptake, and adherence among SMM in Nigeria. The study will provide pertinent data to inform effective design of culturally appropriate PrEP interventions for this vulnerable group.

PI_NAMEs: OGUNBAJO, ADEDOTUN  (contact)

PROGRAM_OFFICER_NAME: STIRRATT, MICHAEL JAMES

PROJECT_TERMS: acceptability and feasibility;Adherence;Africa South of the Sahara;AIDS prevention;Awareness;Behavior Therapy;Biological Assay;Blood;care outcomes;Caring;Cellular Phone;Clinic;community based participatory research;Consolidated Framework for Implementation Research;cost;Data;design;Development;digital health;Dryness;eligible participant;Epidemic;Epidemiology;Face;feasibility testing;follow-up;Funding;Future;General Population;Goals;Grant;harassment;Health Personnel;Health Services;high risk;HIV;HIV Infections;HIV Seronegativity;Homophobia;Homosexuality;Hour;Human immunodeficiency virus test;implementation barriers;implementation framework;implementation science;improved;Incidence;innovation;Intervention;Interview;iterative design;Knowledge;Mentorship;Modeling;Nigeria;Nigerian;Oral;Outcome;Output;Ownership;peer;Persons;Phase;Population;Positioning Attribute;pre-exposure prophylaxis;Process;prototype;Qualitative Methods;Randomized;randomized trial;Randomized, Controlled Trials;Research;Research Personnel;Risk;Risk Reduction;self testing;Services;sexual minority men;Site;social cognitive theory;social stigma;Spottings;Structure;telehealth;Telemedicine;Testing;therapy development;Training;Treatment Efficacy;treatment services;uptake;Victimization;Vulnerable Populations

PROJECT_TITLE: Developing and testing a telehealth intervention to increase HIV pre-exposure prophylaxis uptake and adherence among sexual minority men in Nigeria

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Bioengineering;Genetics;Lung;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE  With each breath and across the lifespan in health and disease, the lung is under dynamic changes of mechanical force. How this force is sensed and translated into molecular cues that impact lung formation, injury repair and function is poorly understood. In this study, we will investigate the role of the cardinal mechanosensor PIEZO channels at the center a molecular feedback mechanism that controls gas exchange niche size and composition during the construction and reconstruction of the lung.

PI_NAMEs: SUN, XIN  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Adult;Aging;Alveolar;alveolar epithelium;Alveolus;Architecture;Area;ATAC-seq;Biophysics;Birth;Bleomycin;Breathing;Bronchopulmonary Dysplasia;Calcineurin;Calcium;Cations;Cell Fate Control;Cell Nucleus;Cell Size;Cells;Childhood;Chromatin;Cues;Cytoskeleton;Data;Dedications;Development;Diagnosis;Disease;Endothelial Cells;Endothelium;Epithelial Cells;Epithelium;Equilibrium;Exhalation;Failure;Feedback;Fibrosis;Fluorescent in Situ Hybridization;Gases;Generations;Genes;Genetic;Genetic Transcription;Gestational Age;Health;improved;in vivo;Infant;Inhalation;Injury;injury and repair;Knowledge;Life;life span;Ligands;Lung;Lung Capacity;lung maturation;mechanical force;Mechanics;mechanotransduction;Mediator;Membrane;Mesenchymal;Mesenchyme;Molecular;mutant;Natural regeneration;Nature;Neurons;Nuclear;Nuclear Lamina;Organ;Organ Size;Pathogenesis;Periodicity;Peripheral;pharmacologic;Piezo 2 ion channel;Piezo ion channels;postnatal;postnatal period;Predisposition;Premature Birth;Proliferating;reconstruction;regenerative;repaired;Resistance;respiratory;response;Role;Saccule structure;Shapes;Signal Transduction;Structural defect;Surface;Technology;Testing;Tissues;transcriptome sequencing;transcriptomics;Translating

PROJECT_TITLE: Mechanosensor Function in the Control of Gas Exchange Surface Size and Composition

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Neurosciences;Pediatric

ORG_CITY: STRATFORD

ORG_NAME: ROWAN UNIVERSITY SCHOOL/OSTEOPATHIC MED

ORG_STATE: NJ

PHR: Project Narrative Social interactions affect the way we think and feel and impact our overall health, which makes understanding the biology of social behavior an important research topic. The neuropeptide vasopressin is an important modulator of social behavior and is predicted to impact brain circuits involved in motivated behaviors and emotional state making it an important target for study. Proposed projects combine new models with modern tools in behavioral neuroscience, cellular physiology, and neuroanatomy to discover the link between vasopressin-responsive brain regions and motivational and emotional processing during social behavior and to identify cellular mechanisms that could be targeted therapeutically.

PI_NAMEs: ROOD, BENJAMIN DAVID (contact);WEST, ELIZABETH A

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Adolescent;Affect;Aggressive behavior;Agonist;Amygdaloid structure;Anatomy;antagonist;anti social;antisocial behavior;Argipressin;autism spectrum disorder;Behavior;behavior test;Behavior Therapy;Behavioral;behavioral study;Biology;Brain;Brain region;Caring;Cell Physiology;cell type;Cells;Child;Child Rearing;Cognition;Cognitive;cognitive testing;Decision Making;delivery vehicle;Disease;Dopamine;Dorsal;electrical property;Electrophysiology (science);Emotional;Emotions;experience;experimental study;flexibility;Gene Expression;Gene Expression Profile;Genetic;genetic approach;Goals;Health;Heterogeneity;Human;improved;improved outcome;in vivo;Individual;insight;interest;Investigation;Knowledge;Life;Link;Literature;loss of function;male;Measures;Medial;Medical;Memory;Mental Depression;Modeling;Modernization;Molecular Genetics;motivated behavior;Motivation;mouse model;Mus;National Institute of Mental Health;nerve supply;neural;neural circuit;Neuroanatomy;Neurobiology;neuromechanism;Neurons;Neuropeptides;Neurosciences;Outcome;Pair Bond;Partner in relationship;patch clamp;Pathway interactions;Pattern;peer;Personality Disorders;pharmacologic;Phenotype;Physiological;Play;Prefrontal Cortex;Psychoses;Psychosocial Stress;Quality of life;Rattus;receptor;Regulation;Reporter;Research;response;Rewards;Rodent;Role;Sampling;Serotonin;sex;Short-Term Memory;Signal Transduction;single-cell RNA sequencing;social;social anxiety;Social Behavior;social influence;Social Interaction;Social Network;social stress;Stimulus;Stream;Stress;Structure of terminal stria nuclei of preoptic region;supportive environment;System;targeted treatment;Territoriality;Testing;Thalamic structure;Therapeutic Intervention;tool;transcriptomics;Transgenic Mice;V1a vasopressin receptor;Vasopressin Receptor;Vasopressins;Viral;Viral Vector;women subjects

PROJECT_TITLE: Role of brain Avpr1a-expressing neurons in modulation of social behavior

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Regenerative Medicine

ORG_CITY: ROCHESTER

ORG_NAME: ADVANCES IN MINERAL METABOLISM

ORG_STATE: MN

PHR: Relevance AIMM annual meeting – E.M. Shore, P.I.  Advances in Mineral Metabolism (AIMM) was established as a scientific conference to present and actively discuss state-of-the-art basic and clinical bone biology in a forum that would be highly stimulating for established experts in the field as well as be collegial and welcoming for young investigators and scientists-in-training. The 35+ year AIMM history, along with the high retention rate of AIMM’s young investigators in the bone field, attests to the value and importance of this meeting. 1

PI_NAMEs: SHORE, EILEEN M (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Aging;Area;Basic Science;Biology;bone;bone cell;bone fracture repair;Bone Growth;bone lead;Bone Regeneration;career;career development;Cartilage;cartilage cell;Case Study;Cell Physiology;Cellular biology;Clinical;Clinical Research;Clinical Sciences;Clinical Treatment;collaborative environment;Colorado;combinatorial;Communication;Connective Tissue;Creativeness;Data;Drug Industry;Education;Educational workshop;Endocrine;Equilibrium;Exercise;Exercise Physiology;Faculty;Fostering;Future;Generations;Goals;Hematopoietic;Implant;improved;Individual;Industrialization;interest;Knowledge;Lead;Learning;Maintenance;mammalian COMP;manufacture;Marrow;meetings;Mentors;Metabolism;Minerals;Modeling;Molecular Genetics;Muscle;Musculoskeletal;Mutation;Natural regeneration;novel;Oral;Orthopedics;Osteogenesis;Participant;Physiology;Postdoctoral Fellow;Process;professor;progenitor;programs;Proteins;Pseudoachondroplastic spondyloepiphyseal dysplasia syndrome;Recording of previous events;repaired;Reporting;Research;Research Personnel;retention rate;Role;Scientist;Senior Scientist;Signal Transduction;Skeletal Development;skeletal stem cell;skeletal tissue;Skeleton;stem cell biology;stem cells;success;symposium;Talents;Technology;Time;Tissues;Training;Translations;treatment strategy;Update;Work

PROJECT_TITLE: Advances in Mineral Metabolism (AIMM) Annual Meeting

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative This proposal will develop new tools for real-time sensing of absolute concentrations of multiple neuromodulatory signals in the brain, using advanced one-photon and two-photon imaging. A detailed understanding of the levels of many neuromodulators and how this neuromodulatory signature changes across behavioral states is sorely lacking. Improved understanding and technology will allow testing of more sophisticated brain neuromodulation methods for improving cognitive and correction of chemical imbalances in the brain across neurologic and psychiatric disorders.

PI_NAMEs: ANDERMANN, MARK L (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: 3-Dimensional;Acetylcholine;Acute;Adenosine;Arousal;awake;Axon;Bathing;behavior test;Behavioral;Boston;Brain;brain cell;Brain region;brain tissue;Calibration;Cannulas;Cells;cellular imaging;Cerebrospinal Fluid;Chemicals;Child;Chronic;Clinical;Closure by clamp;Cognitive;Collaborations;Corticotropin-Releasing Hormone;cost effective;Cultured Cells;Disease;Dopamine;Dose;Drug Delivery Systems;Exhibits;experimental study;Fiber;Fluorescence;fluorescence imaging;Green Fluorescent Proteins;Harvest;Head;high dimensionality;Histamine;Hour;Hydrogels;Hypothalamic structure;Image;Implant;improved;in vivo;Individual;intraperitoneal;lateral ventricle;lens;Liquid substance;Locomotion;Measurement;Measures;Medial;Melatonin;Mental disorders;Methods;Microdialysis;Microfluidics;Monitor;Mus;Nature;Nervous System Disorder;neural patterning;Neuromodulator;Neurons;neuropsychiatry;neuroregulation;Neurosciences;Neurosciences Research;Norepinephrine;novel;optical fiber;optical sensor;optogenetics;Oxytocin;Pattern;Peptides;Pharmaceutical Preparations;Photometry;Photons;preference;Preoptic Areas;quantitative imaging;rational design;Refractive Indices;response;Retinal blind spot;Robotics;sensor;Serotonin;side effect;Signal Transduction;social;Somatostatin;Technology;Testing;Time;tool;two-photon;Vasoactive Intestinal Peptide;Vasopressins;virtual reality

PROJECT_TITLE: Multiplexed Sensing and Control of Neuromodulators and Peptides in the Awake Brain


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative Subretinal fibrosis is a major clinical complication in nAMD patients receiving anti-VEGF therapy. Studies proposed in the current project will define the types of retinal cells that are involved in the formation of fibrotic lesions, and examine the intercellular signaling mechanisms mediated by growth factors and cytokines.

PI_NAMEs: CAI, JIYANG  (contact);MA, JIAN-XING

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Actins;Adoptive Transfer;Aftercare;Age;Age related macular degeneration;Amino Acids;angiogenesis;Area;Blindness;Blood Vessels;Bone Marrow;cell type;Cells;Cellular Structures;Chimeric Proteins;Choroid;Choroidal Neovascularization;Cicatrix;Clinical;Collagen;Complication;Conditioned Culture Media;connective tissue growth factor;cytokine;Development;digital;Disease;effective therapy;Effector Cell;Endothelial Cells;Endothelium;Epithelium;Event;Experimental Models;Exudative age-related macular degeneration;Eye;Fibroblasts;Fibrosis;follow-up;Gene Expression Profile;Genes;Genetic;Genetic Transcription;Glycolysis;Glycolysis Inhibition;Goals;Growth Factor;Human;human tissue;Immunofluorescence Immunologic;In Vitro;in vitro testing;in vivo;inhibitor;intercellular communication;Interleukins;intravitreal injection;Knock-out;Knockout Mice;Laser injury;laser photocoagulation;Lasers;Lesion;Macrophage;Measures;Mediating;Mesenchymal;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Microglia;Mitochondria;Modeling;Molecular;Monitor;mouse model;Mouse Protein;Muller's cell;Mus;Myeloid Cells;nano-string;neovascular;neuroinflammation;novel;Oxidative Phosphorylation;Patients;Pattern;precursor cell;preference;Production;programs;Proliferating;Property;protein biomarkers;Publishing;receptor;Receptor Gene;Recombinant Interleukins;Recombinants;recruit;repaired;response;Retina;retinal damage;Role;Signal Transduction;single-cell RNA sequencing;small molecule inhibitor;Smooth Muscle;Source;Spatial Distribution;Stains;stemness;success;targeted treatment;Testing;Therapeutic Effect;Therapeutic Intervention;Tissues;transcription factor;transdifferentiation;Transforming Growth Factor beta;Transforming Growth Factors;Treatment Factor;validation studies;Vascular Endothelial Growth Factors;Vimentin;Vision;Visual Acuity;VLDL receptor;Wild Type Mouse

PROJECT_TITLE: Metabolic reprogramming of endothelial precursor cells in subretinal fibrosis

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_DEPT: ANESTHESIOLOGY

PHR: Project Narrative Responsible for fast synaptic transmission throughout the nervous system, pentameric ligand-gated ion channels (pLGICs) are the targets of many drugs essential to the modern practice of anesthesiology and critical care medicine, but drug development in this field has been stagnant for many years. In this proposal, I will use advanced computational techniques to understand the structural determinants of pLGIC modulation via lipids, which have been suggested to have molecular mechanisms that overlap with anesthetics. The outcome of this work will be a detailed molecular model of how lipophilic species allosterically modulate pLGICs, opening new avenues for drug discovery in anesthesia.

PI_NAMEs: ARCARIO, MARK JOSEPH (contact)

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TERMS: addiction;Address;Advisory Committees;Affect;Affinity;alpha-bungarotoxin receptor;Anesthesia procedures;Anesthesiology;Anesthetics;Award;Binding;Binding Sites;Biophysics;career;career development;Characteristics;chronic pain management;Computational Technique;computer studies;Contracts;Critical Care;Cryoelectron Microscopy;Data;Dementia;desensitization;design;Development;Docosahexaenoic Acids;Drug Design;drug development;drug discovery;Electrophysiology (science);Elements;Equilibrium;Erwinia;Essential Drugs;Family;Fatty Acids;Fluorescent Probes;Free Energy;Goals;Grain;Human;innovation;insight;interest;Ion Channel;Ion Channel Gating;Ions;Knowledge;Ligands;Lipid Binding;Lipids;lipophilicity;Medicine;member;Membrane;Membrane Proteins;Mentors;method development;Methods;Modeling;Modernization;Molecular;Molecular Conformation;molecular dynamics;molecular modeling;Movement;Nervous System;Neuromuscular Blocking Agents;Neuromuscular Diseases;neurosteroids;new therapeutic target;Nicotinic Receptors;novel;novel therapeutics;Outcome;Pharmaceutical Preparations;Pharmacology;Phospholipids;Physicians;Physiological;Polyunsaturated Fatty Acids;protein function;protein structure;Proteins;Publishing;rational design;Research;research and development;Rest;Scientist;simulation;Site;skills;structural determinants;Structure;supportive environment;Synaptic Transmission;System;Techniques;Testing;Thermodynamics;Transmembrane Domain;Universities;Washington;Work

PROJECT_TITLE: Unraveling how Lipophilic Modulators Alter pLGIC Function via Interactions with the M4 Transmembrane Helix

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE – Overall UCSF Older Americans Independence Center (OAIC) The UCSF OAIC provides investigators a comprehensive suite of resources, mentorship, and support to advance science in our theme area, which is focused on predictors, outcomes, and amelioration of late-life disability in medically and socially vulnerable older adults. We seek to continue our superb track record of developing an interdisciplinary cadre of investigators whose research yields major, clinically impactful advances in our theme area and is ultimately translated to improving care and quality of life for vulnerable older adults with or at risk for disability.

PI_NAMEs: COVINSKY, KENNETH E. (contact);STEINMAN, MICHAEL A.

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Acceleration;Achievement;Address;Advance Care Planning;advanced disease;Affect;age acceleration;Aging;American;Area;Award;Capsicum;career development;caregiver quality of life;Caring;Clinical;clinical practice;Clinical Research;Collaborations;Communities;community center;Complex;Consultations;cost;Data;data resource;Data Sources;Dedications;Dermatology;Development;Diabetes Mellitus;disability;Disability research;disability risk;disabled;Discipline;Education;Elderly;Enrollment;Ensure;experience;forging;Fostering;Funding;Future;Geriatrics;Goals;Guidelines;Healthcare;HIV;Homelessness;Hospitals;Impaired cognition;Imprisonment;improved;improved outcome;innovation;instrument;interdisciplinary collaboration;Internet;Journals;late life;Leadership;literacy;Malignant Neoplasms;medical specialties;medical vulnerability;Mentors;Mentorship;Mission;multiple chronic conditions;Neurology;next generation;Nursing Homes;older adult;Older Population;Oncology;Operative Surgical Procedures;Outcome;Outcomes Research;Patients;Persons;Pilot Projects;Policies;Poverty;prevent;prognostic;programs;Publications;Quality of life;Research;Research Methodology;Research Personnel;Research Support;Resources;Risk;safety net;Science;Screening for cancer;Social Interaction;Social isolation;social vulnerability;Structure;success;Sum;therapy development;tool;Translating;user-friendly;Vulnerable Populations;web site;web-based tool;Work


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: COVINSKY, KENNETH E. (contact)

PROJECT_TERMS: Achievement;Address;advanced disease;Aging;American;Area;Award;Benchmarking;career;Caring;Clinical;clinical care;Clinical Research;Collaborations;Communication;Communities;comorbidity;cost;data resource;Dedications;Development;disability;Discipline;Elderly;Enrollment;Ensure;Family Caregiver;Fostering;Funding;Glues;Goals;Grant;Health;Healthcare;Impaired cognition;improved;innovation;Investments;Journals;Lasers;late life;Lead;Leadership;Link;Lung Diseases;Malignant Neoplasms;Medical;medical specialties;medical vulnerability;Mentors;Mission;Monitor;multidisciplinary;next generation;older adult;Older Population;Outcome;outreach;Persons;Policies;Poverty;pro-aging;Productivity;programs;Progress Reports;Publications;Quality of life;remediation;Research;Research Personnel;research study;Research Support;Resources;Review Committee;Science;Scientist;social;social disparities;social vulnerability;stem;success;Translating;translational potential;translational scientist;United States National Institutes of Health;Vision;Vulnerable Populations;Work

PROJECT_TITLE: Leadership and Administrative Core (LAC)


PI_NAMEs: BOSCARDIN, W. JOHN (contact)

PROJECT_TERMS: Address;Aging;American;Area;Biological Markers;career development;Cohort Studies;Complex;Consultations;COVID-19 pandemic;Data;Data Analyses;data management;Data Set;design;Development;disability;education research;Electronic Health Record;Ethnic Origin;Future;Genetic;Growth;Health;Health and Retirement Study;improved;Individual;innovation;Interdisciplinary Study;Investments;longitudinal analysis;Measurement;Measures;Medicare;Methodology;Methods;novel;older adult;outcome prediction;personalized approach;Physical Performance;Problem Solving;Procedures;programs;Race;Recording of previous events;Research;Research Design;Research Methodology;Research Personnel;research study;Research Support;Risk;Science;Services;socioeconomics;success;trend

PROJECT_TITLE: RC1 - The Data and Analysis Core (DAC)


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Respiratory viral infections can lead to acute respiratory distress syndrome (ARDS), which is characterized by detrimental hyperinflammation that damages the pulmonary vascular endothelium, causing impaired gas exchange and a patient mortality rate as high as 45%. The fundamental vascular progenitor cell(s) that restore the capillary network after influenza injury is unknown. This proposal will therefore investigate the origin and molecular regulation of a putative vascular progenitor population derived from the venous endothelium, providing a groundwork for future studies aimed at enhancing vascular repair after pulmonary injury.

PI_NAMEs: WONG, JOANNA  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: 2019-nCoV;Ablation;Acute Respiratory Distress Syndrome;Alveolar;Alveolar Macrophages;Alveolus;angiogenesis;apoAI regulatory protein-1;Area;Automobile Driving;beta-Chemokines;Blood capillaries;Blood Vessels;Brain;Cell Proliferation;Cell secretion;Cell Separation;cell type;chemokine;chemokine receptor;Chemotaxis;Clone Cells;conditional knockout;Data;Death Rate;Development;Dichloromethylene Diphosphonate;Edema;Endothelial Cells;endothelial regeneration;endothelial repair;endothelial stem cell;Endothelium;Epithelium;Exhibits;Frequencies;Future;Gases;Goals;Height;Human;Immune;Immune response;Impairment;improved;in vivo;Individual;Infiltration;Inflammatory;Inflammatory Response;Influenza;Influenza A Virus, H1N1 Subtype;influenza infection;Injury;innovation;interstitial;Intravenous;Label;Ligands;Liposomes;Liquid substance;Lung;lung injury;lung microvascular endothelial cells;lung regeneration;Macrophage;Mediating;Modeling;Molecular;monocyte;mortality;Mus;Myeloid Cells;Organ;Organogenesis;paracrine;Pathway interactions;Patient-Focused Outcomes;Patients;Physiological;Pneumonia;preservation;prevent;progenitor;Proliferating;Pulmonary Edema;pulmonary function;Pulmonary veins;reconstitution;recruit;Regenerative response;Regulation;repaired;Reporter;Respiratory Tract Infections;response;restoration;Risk Factors;Role;Signal Transduction;single-cell RNA sequencing;Source;Specific qualifier value;stem cell population;stem cells;targeted treatment;Techniques;Testing;Time;tissue regeneration;tissue repair;transcription factor;Transplantation;Umbilical vein;Vascular Endothelium;Vascular regeneration;Vascular remodeling;Veins;Venous;venule;Viral;Viral Respiratory Tract Infection;Virus;Virus Diseases;Zebrafish

PROJECT_TITLE: Pulmonary Vascular Regeneration via Venous Endothelial Progenitors


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homelessness;Patient Safety;Social Determinants of Health

PI_NAMEs: SUDORE, REBECCA L (contact)

PROJECT_TERMS: Address;Advanced Development;Affect;Aging;Alzheimer's disease related dementia;American;Area;Capsicum;Caring;Collaborations;Communities;community advisory board;community engaged research;Complex;Consent;Consultations;Data;Data Collection;Dementia;design;Development;Diabetes Mellitus;disability;Disease;education research;Enrollment;Evolution;Faculty;food insecurity;frailty;Funding;Future;Geriatrics;Health;health literacy;Homelessness;human subject;Impaired cognition;Impairment;implementation science;Incidence;Informed Consent;innovation;Institutional Review Boards;Interdisciplinary Study;International;Intervention;Knowledge;late life;literacy;marginally housed;Measures;medical vulnerability;Methodology;Methods;multiple chronic conditions;novel;older adult;Older Population;Outcome;Outcome Measure;outreach;Participant;patient safety;Pharmaceutical Preparations;Population;Poverty;Procedures;Prospective Studies;Protocols documentation;randomized trial;recruit;Research;Research Methodology;Research Personnel;Resources;response;Science;Services;skills;Social isolation;Social support;social vulnerability;support tools;Testing;theories;Work

PROJECT_TITLE: RC2 - The Vulnerable Aging Research Core (VARC)


NIH_SPENDING_CATS: Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: EAST LANSING

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

ORG_STATE: MI

PHR: Project Narrative Many important problems in child health and development may result from a mother’s environment during pregnancy. We are a coalition of scientists in Michigan who plan to 1) continue collecting information from the 1,600 families we have already enrolled in the Environmental influences on Child Health Outcomes (ECHO) study; and 2) enroll another 540 families from diverse populations. Working together with other study groups who are part of the national ECHO program, we hope to learn what changes might be made during a woman’s pregnancy that could prevent later problems in child health and development.

PI_NAMEs: BARONE, CHARLES JAMES;ELLIOTT, MICHAEL R.;FUSSMAN, CHRIS ;KERVER, JEAN MARIE (contact);PANETH, NIGEL SEFTON;RUDEN, DOUGLAS M

PROGRAM_OFFICER_NAME: LAESSIG, SUSAN ALISON

PROJECT_TERMS: Acceleration;Advisory Committees;African American;Area;Birth;Body mass index;Chemical Exposure;Child;Child Development;Child Health;Cities;Clinic;cohort;Collaborations;Conceptions;Consent;Data;Data Collection;design;Development;early life adversity;Eligibility Determination;Enrollment;Environment;epigenetic aging;Epigenetic Process;Exposure to;extracellular;Family;Feeding Patterns;follow-up;Follow-Up Studies;Funding;Future;Goals;gut microbiome;Health;Heavy Metals;improved;infancy;Infant;Institution;Iodine;Iron;Leadership;Learning;Left;Live Birth;Location;Maternal and Child Health;Mediator;men;Metabolic;Michigan;Micronutrients;Mothers;National Children's Study;Neighborhoods;neurodevelopment;Nutritional;Obesity;offspring;Outcome;Outcome Study;Paper;Participant;Patient Recruitments;Perinatal Exposure;Phase;phthalates;Plasma;Poly-fluoroalkyl substances;Population Heterogeneity;Positioning Attribute;Pregnancy;Pregnant Women;Premature Birth;prenatal;Prenatal care;prenatal exposure;prevent;programs;Protocols documentation;recruit;Recurrence;Research;Resources;Risk;Rural;Rural Community;rural underserved;Sampling;Sampling Studies;Science;Scientist;Site;sperm cell;stressor;study population;Testing;Visit;Woman;Work;working group;Writing

PROJECT_TITLE: Prenatal Exposures and Child Health Outcomes 2: Increasing ECHO Urban and Rural Diversity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-S(50)R]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Duchenne/ Becker Muscular Dystrophy;Gene Therapy;Genetics;Heart Disease;Muscular Dystrophy;Nanotechnology;Orphan Drug;Pediatric;Pediatric Cardiomyopathy;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Patients with Duchenne muscular dystrophin lack dystrophin expression and die of dilated cardiomyopathy in the second or third decade of life. This proposal seeks to investigate whether gene therapy strategies to deliver full-length dystrophin can prevent the pathogenic progression of diseased cardiomyocytes. This innovative platform capitalizes on bioengineered hydrogels and patient-derived induced pluripotent stem cells to assess gene therapy strategies that address the root cause of the disease.

PI_NAMEs: EGUCHI, ASUKA  (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Address;adeno-associated viral vector;Advisory Committees;Affect;Award;Biochemical;Biochemistry;Biological Assay;Biomedical Engineering;Calcium;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiovascular Diseases;Cardiovascular system;career;career development;Cell Death;Cell membrane;Cell Survival;Cells;Cellular biology;Cellular Morphology;Cicatrix;Code;Contracts;coronary fibrosis;Cytoskeletal Proteins;Data;Defect;Dependovirus;design;Development Plans;Dilatation - action;Dilated Cardiomyopathy;Disease;disease model;Disease Progression;Duchenne cardiomyopathy;Duchenne muscular dystrophy;Dyes;Dystrophin;Echocardiography;efficacy evaluation;Engineering;Ensure;Exhibits;experimental study;extend lifespan;Extracellular Matrix;Fibrosis;Functional disorder;gene therapy;Heart;Heart Diseases;Heart failure;heart function;Histology;human induced pluripotent stem cells;Hydrogels;Image;Impairment;improved;induced pluripotent stem cell;innovation;Learning;Left ventricular structure;Length;Life;life span;link protein;lipid nanoparticle;Luciferases;male;Measures;Mendelian disorder;Mentored Research Scientist Development Award;Mentors;Mentorship;Methods;Microscopy;mouse model;Muscle;muscle degeneration;Muscular dystrophy cardiomyopathy;Mutation;mutation correction;nanoparticle delivery;novel;Onset of illness;Pathogenicity;Pathologic;patient derived induced pluripotent stem cells;Patients;pediatric cardiologist;Phenotype;premature;prevent;programs;promoter;protein expression;Proteins;Quality of life;ratiometric;Reactive Oxygen Species;reduce symptoms;Reporter;Research;Research Personnel;Respiratory Failure;response;restoration;Skeletal Muscle;skeletal muscle wasting;skills;Stroke Volume;Symptoms;Techniques;Telomere Shortening;Testing;Therapeutic Effect;therapy design;Thinness;Tissues;Traction Force Microscopy;Training;Variant;vector;Ventricular;Western Blotting

PROJECT_TITLE: Gene Therapy Design Principles for Duchenne Muscular Dystrophy


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: SMITH, ALEXANDER KELIIMOEANU (contact)

PROJECT_TERMS: Address;Affect;Aging;American;Area;Attention;Award;career;Caring;Child;Clinical Sciences;Communities;comorbidity;COVID-19 pandemic;Data;Development;disability;Equity;Exclusion;experience;Faculty;flexibility;Funding;Future;Goals;Grant;Growth;Heart failure;Homelessness;Impaired cognition;innovation;interest;K-Series Research Career Programs;late life;Lung Diseases;Medical;Medical Students;medical vulnerability;member;Mentors;mid-career faculty;Mission;Nursery Schools;older adult;Outcome;Parents;Population;Population Heterogeneity;Poverty;pressure;programs;Progress Reports;Quality of life;Race;recruit;Research;Research Design;Research Personnel;Resources;senior faculty;social determinants;social vulnerability;success;Talents;Training;Transition Career Development Award (K22);Translational Research;Vulnerable Populations

PROJECT_TITLE: Pilot / Exploratory Studies Core (PESC)


NIH_SPENDING_CATS: Aging

PI_NAMEs: WALTER, LOUISE C. (contact)

PROJECT_TERMS: Acceleration;Aging;American;Anesthesiology;Area;Basic Science;career;Career Choice;career development;Clinical;Clinical Research;Communication;Competence;Data Analyses;Data Collection;Data Element;Dermatology;design;Development;Development Plans;disability;Discipline;Discipline of Nursing;early-career faculty;Education;education research;education resources;Educational Activities;Educational Curriculum;Educational workshop;Elderly;experience;Faculty;faculty mentor;Fostering;Funding;Geriatrics;Geroscience;Goals;Grant;Health;health equity;Health Occupations;Hepatology;HIV;Hospitals;improved;Internal Medicine;Journals;K-Series Research Career Programs;late life;Leadership;Manuscripts;medical specialties;Medicine;Mentors;Mentorship;Minority;Mission;Needs Assessment;Nephrology;Neurology;Oncology;Operative Surgical Procedures;Outcome;Palliative Medicine;Pathway interactions;peer coaching;Physical therapy;programs;Psychiatry;Publications;Publishing;Research;Research Personnel;Research Support;Resources;Scholars Program;Schools;Services;skills;Social Sciences;Structure;success;Talents;Time;tool;Training;Training and Education;Translations;Underrepresented Students;United States National Institutes of Health;Urology;Vulnerable Populations;Wages;Work;Writing

PROJECT_TITLE: Research Education Core (REC)


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Cancer;Hematology;Neurodegenerative;Neurosciences;Orphan Drug;Ovarian Cancer;Peripheral Neuropathy;Rare Diseases;Women's Health Research

ORG_CITY: Frederick

ORG_NAME: UP THERAPEUTICS, INC.

ORG_STATE: MD

PHR: Project Narrative: Three new proteasome-targeting chemotherapeutic drugs reached the market in the past decade. Although these peptide-based proteasome inhibitors are effective against multiple myeloma, unfortunately they have not proven useful to treat solid tumors (e.g. Ovarian Cancer). Up Therapeutics is developing novel small molecule inhibitors that are not peptide-based and target a different component of the proteasome (RPN13) as drug candidates for the treatment of solid tumors, notably ovarian cancer.

PI_NAMEs: ANCHOORI, RAVI KUMAR (contact)

PROGRAM_OFFICER_NAME: POND, MONIQUE ADRIANNE

PROJECT_TERMS: Acute;Address;analog;anticancer activity;Antigens;Apoptosis;Australia;Award;behavior test;Biochemical;Biological Assay;Blood;Body Weight Changes;Bortezomib;CA-125 Antigen;cancer cell;Cancer cell line;Cancer Model;Cancer Patient;cancer therapy;Canis familiaris;Carboplatin;Cardiotoxicity;cell killing;chemotherapy;Chemotherapy-Oncologic Procedure;Cisplatin;Clinical;Clinical Trials;Country;Data;design;Deubiquitination;Development;Dose;Dose Limiting;drug candidate;Drug resistance;Drug Targeting;Effectiveness;endoplasmic reticulum stress;Epithelial ovarian cancer;Exhibits;experience;Female;Formulation;Goals;Greater sac of peritoneum;Gynecologic Pathology;Half-Life;Human;Improve Access;improved;improved outcome;in vitro activity;in vivo;Industry;inhibitor;Lead;Legal patent;Licensing;Liquid substance;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mantle Cell Lymphoma;manufacture;Marketing;Medical;Medical Oncologist;method development;misfolded protein;Molecular Weight;Monitor;mouse model;multicatalytic endopeptidase complex;Multiple Myeloma;Mus;neoplastic cell;neurophysiology;neurotoxicity;Neutropenia;Normal Cell;Normal tissue morphology;novel;novel therapeutics;Nucleosome Core Particle;Operative Surgical Procedures;Organ;Ovarian;Paclitaxel;patient derived xenograft model;Patients;peptide drug;Peptides;Peripheral Nerves;Peripheral Nervous System Diseases;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Pharmacologic Substance;Platinum;Platinum Compounds;Poly(ADP-ribose) Polymerase Inhibitor;preclinical development;Predisposition;Process;Property;Proteasome Inhibition;Proteasome Inhibitor;protein aggregation;protein metabolism;Proteins;proteotoxicity;Rattus;receptor;Recurrence;refractory cancer;Regimen;Resistance;response;Safety;safety study;Scientist;side effect;small molecule;small molecule inhibitor;Solid;Solid Neoplasm;Speed;standard of care;Stress;Structure;Survival Rate;Symptoms;targeted agent;Testing;Therapeutic;therapeutic evaluation;Therapeutic Index;Thrombocytopenia;Tissues;Toxic effect;Toxicology;TP53 gene;Treatment Efficacy;treatment response;tumor;Tumor Debulking;Tumor Tissue;tumor xenograft;Ubiquitin;ubiquitin isopeptidase;Universities;Validation;Vascular Endothelial Growth Factors;Vertebral column

PROJECT_TITLE: Development of a novel small molecule RPN13 inhibitor and therapeutic for advanced ovarian cancer patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-T(10)B]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: AMHERST

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Public Health Significance Medication harm is a leading cause of injury and avoidable harm in health care systems across the world. This Patient-Driven Medication Safety Learning Laboratory in Care Transitions project will ultimately lead to the design of interventions that are highly targeted to older adults and their caregivers who are residing in some of the most marginalized communities. The interventions created through this research, from the patient perspective, will further address health equity, and will make all communities, regardless of what zip code a person lives in, healthier.

PI_NAMEs: CHEN, HEUI-YEN ;JACOBS, DAVID ;SINGH, RANJIT  (contact)

PROGRAM_OFFICER_NAME: SAMAD, FARZANA

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ORG_NAME: DREXEL UNIVERSITY

PHR: Project Narrative Parents of infants hospitalized in a neonatal intensive care unit (NICU) experience significant trauma and chronic stress which can impair parental mental health and functioning as well as parent-infant interactions and infant development. Since NICUs are not equipped to routinely screen parents for depression, trauma and anxiety, most parents do not receive the mental health support and treatment they need to cope effectively with this experience. EmBRACE (Empower NICU – A Bridge to Resources for Adjusting and Coping with Emotions) is a novel mobile health (mHealth) application that will be developed and tested for screening and monitoring all NICU parents for psychological symptoms, and connecting them with customized referral information, support and coping strategies to optimize parent mental health and infant outcomes.

PI_NAMEs: GELLER, PAMELA A (contact)

PROGRAM_OFFICER_NAME: LOMOTAN, EDWIN A

PROJECT_TITLE: Empower NICU - A Bridge to Resources for Adjusting and Coping with Emotions (EmBRACE)

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Hematology;Infectious Diseases;Sepsis

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative More than one-half of patients with life-threatening infections (sepsis) have evidence of injury to the heart muscle called ‘myocardial injury’. Myocardial injury increases the risk of death, but there is currently little information to inform the best approach to evaluate or treat patients with myocardial injury during sepsis. We propose the “Informing best practices for evaluation and treatment of myocardial injury during sepsis” study to better understand and guide the care provided to the millions of patients per year with myocardial injury during sepsis.

PI_NAMEs: WALKEY, ALLAN J. (contact)

PROGRAM_OFFICER_NAME: SIDDIQUI, AYESHA SAEED

PROJECT_TERMS: Acute;Address;Adoption;Adrenergic beta-Antagonists;Affect;Angiography;Anticoagulants;Anticoagulation;Aspirin;Atherosclerosis;atherosclerotic plaque rupture;Benchmarking;Big Data;Biological Markers;Cardiac;Cardiology;cardiovascular risk factor;Cardiovascular system;Caring;Clinical;Clinical Pathways;clinical practice;clinical risk;Clinical Trials;clinically actionable;cohort;Collaborations;Complication;Coronary Arteriosclerosis;Critical Illness;Data;Data Analyses;design;Diagnosis;Diagnostic;Echocardiography;effectiveness evaluation;Electrocardiogram;Electronic Health Record;Evaluation;Event;Exhibits;Functional disorder;Future;Guidelines;Healthcare;Healthcare Systems;Hemorrhage;hospital care;Hospital Mortality;Hospitalization;Hour;Immune response;improved;individual patient;Infection;Injury;innovation;Inpatients;Integrated Health Care Systems;Intervention;Intervention Trial;Ischemia;Judgment;Knowledge;Learning;Life;Link;longitudinal dataset;Machine Learning;Measures;Methods;Modeling;Morbidity - disease rate;mortality;mortality risk;Myocardial Infarction;myocardial injury;Myocardium;novel strategies;Observational Study;optimal treatments;Organ;Outcome;Pathway interactions;Patient Care;Patients;Pattern;Practice Management;Practice Pattern Variations;Predictive Factor;predictive modeling;Probability;randomized trial;Recommendation;Recording of previous events;Research Methodology;Risk Factors;risk stratification;Sepsis;Serum;structural heart disease;Testing;Thallium Myocardial Perfusion Imaging Stress Test;Therapeutic;treatment effect;Treatment Protocols;Troponin;Uncertainty;United States;Variant;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(02)M]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Breast Cancer;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases;Women's Health Research

PHR: PROJECT NARRATIVE Dr. Bonnie Ky proposes to augment her scientific skills in biomedical informatics, data science, the social determinants of health, and racial inequities in cardio-oncology; mentoring skills in training the next generation of physician scientists; and program building and leadership skills in cardio-oncology patient-oriented research.

PI_NAMEs: KY, BONNIE  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Age Years;Algorithms;androgen deprivation therapy;Anthracycline;Area;Award;Biological Markers;biomedical informatics;Black American;Black race;black women;Breast Cancer Patient;Breast Cancer therapy;cancer care;cancer clinical trial;Cancer Patient;cancer prevention;cancer survival;Cancer Survivor;cancer therapy;Cardiotoxicity;Cardiovascular system;career;career development;Cause of Death;Cessation of life;Characteristics;Clinical;Clinical Sciences;cohort;Cohort Studies;Collection;comorbidity;Computerized Medical Record;Data;Data Science;Derivation procedure;Development;Disease;Disease Outcome;disorder control;Disparity;Early Diagnosis;Echocardiography;Education;electronic data;Ensure;Environment;Equity;ethnic disparity;Ethnic Origin;experience;Future;Goals;Health;health care disparity;health difference;health inequalities;Health Sciences;Health system;Heart failure;hormone therapy;Hyperlipidemia;Hypertension;improved;Incidence;Individual;individual patient;Inequity;innovation;insight;Institution;K-Series Research Career Programs;Knowledge;Lead;Leadership;Life Expectancy;Longitudinal cohort study;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Mechanics;medical schools;Medicine;men;Mentors;Mentorship;Metabolic;Methodology;mid-career faculty;mortality;mortality risk;Myocardial;Myocardial Infarction;Natural Language Processing;new growth;next generation;Oncology;Outcome;patient oriented;patient oriented research;Patient risk;Patient-Focused Outcomes;Patients;Pennsylvania;phase III trial;Phenotype;Physicians;Population;population based;Productivity;Prognosis;Prognostic Factor;programs;prospective;Prostate Cancer therapy;Qualifying;Race;racial disparity;racial diversity;Radiation therapy;Recording of previous events;Reproducibility;Research;Research Design;Research Personnel;Risk;Risk Factors;risk mitigation;Science;Scientist;skills;social health determinants;social structure;Sociology;Statistical Methods;Stroke;success;Sudden Death;Survivors;System;targeted treatment;Time;Training;tumor;Universities;Woman;Work

PROJECT_TITLE: MENTORING IN PATIENT-ORIENTED RESEARCH IN DEEP PHENOTYPING IN CARDIO-ONCOLOGY

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: The Yale OAIC will promote the functional independence of older Americans by increasing scientific knowledge related to multifactorial geriatric conditions, by advancing the science of clinical decision making in multimorbid older persons, by educating and training early-stage investigators in aging research from a multifactorial perspective, and by developing and implementing innovative methods that will facilitate rigorous and high impact research on multifactorial geriatric conditions.

PI_NAMEs: GILL, THOMAS MICHAEL (contact)

PROJECT_TITLE: Claude D. Pepper Older Americans Independence Center at Yale


PROJECT_TERMS: Adherence;Administrator;Advisory Committees;Aging;American;Award;Basic Science;Biometry;Board Certification;Capsicum;career;career development;Center Core Grants;Clinical;Clinical Research;clinically relevant;cohesion;Collaborations;Communities;Complement;design;Development;Discipline;Discipline of Nursing;Elderly;Ensure;environmental enrichment for laboratory animals;Evaluation;Evaluation Research;experience;Faculty;federal policy;Fostering;Funding;Geroscience;Gills;Goals;Government;Grant;improved;innovation;Institution;Interdisciplinary Study;Intervention;Investigation;K-Series Research Career Programs;Knowledge;knowledge base;Lead;Leadership;Maintenance;medical schools;meetings;Mentorship;Monitor;operation;Outcome;Persons;Physicians;Policies;Preparation;Procedures;Productivity;programs;Progress Reports;Public Health;recruit;Report (document);Reporting;Research;Research Personnel;Resource Allocation;Resources;Scientific Advances and Accomplishments;Scientist;senior faculty;Strategic Planning;success;Talents;Testing;Time;Training;Training Programs;Translational Research;Translations;Universities

PROJECT_TITLE: Leadership and Administrative Core


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Lung;Patient Safety;Rehabilitation

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE The proposed research will evaluate whether targeted respiratory muscle exercises preserve breathing function, reduce shortness of breath, and accelerate mobility after total joint replacement surgery. The proposal is relevant to public health because the knowledge learned it will increase our understanding of the impacts of surgery on breathing and could lead to improved approaches to prepare and recover from total joint replacement surgery.

PI_NAMEs: SMITH, BARBARA K (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Academic Medical Centers;Acceleration;Acute;Address;Adult;Age;Anesthesia procedures;Attenuated;Biological;Breathing;Cardiac Surgery procedures;Caring;Chemosensitization;Clinical;clinical practice;Clinical Research;comorbidity;Consent;Controlled Study;Coughing;Data;Day Surgery;Destinations;Deterioration;Dyspnea;Enrollment;Evidence based treatment;Exercise;Exploratory/Developmental Grant;Face;Fiber;follow-up;Frequencies;Future;Generations;Health Services Accessibility;high reward;high risk;Hospitalization;Hospitals;Hour;Impairment;improved;Individual;Inpatients;Inspiratory Capacity;Knowledge;Learning;Length of Stay;Lower Extremity;Lung;Lung Diseases;Mechanical ventilation;Medical;Medical center;Methods;Morbidity - disease rate;Motor;Muscle;Muscle function;neural;neuromuscular;neuromuscular function;neuromuscular plasticity;novel;older adult;Operative Surgical Procedures;Outcome;patient population;Patients;Postoperative Complications;Postoperative Period;postoperative recovery;Preoperative Care;Preparation;prescription opioid;preservation;pressure;Proteolysis;Public Health;pulmonary function;Randomized;Readiness;Recovery;recruit;Rehabilitation therapy;Replacement Arthroplasty;Research;Resources;respiratory;Respiratory Diaphragm;Respiratory Muscles;Respiratory physiology;Risk;Risk Factors;safety net;Schedule;sex;Shortness of Breath;Smoker;socioeconomic disadvantage;standard of care;Supervision;surgery outcome;Testing;Time;Training;ultrasound;ventilation;Vital capacity;Walking

PROJECT_TITLE: Inspiratory Muscle Training to Improve Total Joint Arthroplasty Outcomes


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Digestive Diseases;Liver Disease;Networking and Information Technology R&D (NITRD)

ORG_CITY: Woburn

ORG_NAME: JAVELIN BIOTECH

PHR: During drug development, it is crucial to understand the clearance mechanisms, clearance rate, and any potential drug-drug interactions of small molecule drugs to ensure safety; however, the rat models currently used for this purpose are sub-optimal in terms of time, cost, and applicability to humans. Our solution to this unmet need is an integrated platform that merges a human liver tissue chip and translational software that will reduce the cost and risk associated with drug development. Successful completion of this proposal by optimizing the chip design to enhance usability, evaluating and validating different drug clearance mechanisms, and comparing Javelin’s clinical predictions to known human clearance profiles, will advance the commercial readiness and accelerate commercial adoption of Javelin’s Hepatic Clearance platform, delivering improved R&D productivity to industry and better drugs to patients.

PI_NAMEs: CIRIT, MURAT  (contact)

PROGRAM_OFFICER_NAME: RUDNICKI, DOBRILA DODA

PROJECT_TERMS: 3-Dimensional;Acceleration;Adoption;African American;Albumins;Algorithms;Animal Model;Animals;Architecture;Asian;Biliary;Biological;Biological Markers;candidate selection;Canis familiaris;Caucasians;Cells;Clinical;clinical predictors;clinical translation;Clinical Trials;cloud based;Coculture Techniques;Collection;commercialization;Complex;Computer software;Consumption;cost;cost effective;Data;Data Analyses;design;Development;Differential Equation;Diffusion;drug candidate;drug clearance;Drug Combinations;drug development;drug discovery;drug disposition;Drug Industry;Drug Interactions;Drug Kinetics;drug metabolism;Ensure;Enzymes;Equipment;Ethnic Origin;Evaluation;Excretory function;Family suidae;Fee-for-Service Plans;Female;Financial Hardship;Hepatic;Hepatocyte;Hispanic;Human;improved;in silico;In Vitro;in vivo;Industry;insight;Lead;lead optimization;Liver;liver function;male;manufacturing scale-up;Mass Spectrum Analysis;Measurement;Measures;Mediating;Metabolic;Metabolic Clearance Rate;Metabolism;Methods;microphysiology system;Modeling;nonhuman primate;novel strategies;Outcome;Patients;Perfusion;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacology and Toxicology;Phase;Physiological;Physiology;Population;Pre-Clinical Model;predict clinical outcome;Productivity;Property;Qualifying;Rattus;Readiness;Reproducibility;Reproducibility of Results;research and development;Risk;Risk Reduction;Rodent;Safety;Sampling;scale up;Service delivery model;Small Business Innovation Research Grant;small molecule;Suspensions;System;Technology;Testing;Time;Tissue Engineering;Tissue Microarray;Tissues;tool;Training;Translating;Translations;uptake;Urea;usability

PROJECT_TITLE: Hepatic Clearance Chip for Pharmacokinetics


NIH_SPENDING_CATS: Aging;Bioengineering;Networking and Information Technology R&D (NITRD)

PI_NAMEs: FERRANTE, LAUREN  (contact)

PROJECT_TERMS: Aging;American;Award;Biometry;Biostatistics Core;Budgets;Capsicum;Caring;Clinical Informatics;Collaborations;Communities;Computer software;Consultations;Data;Data Collection;data management;Data Mart;Data Reporting;data sharing;database design;design;Development;Education;Elderly;electronic data;electronic data capture system;Ensure;Equipment;Extramural Activities;Fostering;Funding;Funding Agency;Future;Goals;Grant;Health system;improved;Informatics;informatics infrastructure;Infrastructure;innovation;Institution;Investigation;Mentors;Methodology;Mission;Monitor;next generation;novel;older adult;operation;participant safety;Peer Review;Policies;Population;programs;Publications;recruit;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resources;Services;Silver;skills;Software Design;software development;Software Tools;System;technological innovation;tool;Training;United States National Institutes of Health;Veterans Health Administration;Work

PROJECT_TITLE: CORE-001 - OPERATIONS CORE


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurosciences

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE Perception reflects a combination of sensory drive from the periphery and inputs from central brain regions. This proposal will use electrical brain stimulation to control inputs from cognitive brain areas that project to the ventral visual pathway in the human brain, and measure and model how these projections influence the representation and perception of complex visual stimuli. These studies will provide the basis for future research to design perturbation based strategies that mimic human attentional conditions.

PI_NAMEs: HERMES, DORA  (contact);KAY, KENDRICK NORRIS;WORRELL, GREGORY A

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Affect;Animal Model;Anterior;Area;Attention;Behavior;behavior measurement;Behavioral;Brain;Brain region;brain surgery;Categories;Clinic;Clinical;Cognitive;Complex;Cortical Column;Data;design;Diffusion Magnetic Resonance Imaging;Effectiveness;Electric Stimulation;electrical potential;Electrical Stimulation of the Brain;Electrocorticogram;Electrodes;Electroencephalography;Epilepsy;Feedback;Frequencies;Functional Magnetic Resonance Imaging;Goals;gray matter;Human;Image;Implanted Electrodes;insight;Instruction;intraparietal sulcus;Judgment;Location;Measurement;Measures;mental representation;Methods;Modeling;Monitor;MRI Scans;multidisciplinary;network models;neural;neuroimaging;Neurons;neurotransmission;novel;Outcome;Parietal;Pathway interactions;Patients;Perception;Performance;Physical environment;Physiologic pulse;Physiological;Play;predictive modeling;Process;Reaction Time;Research;response;Role;Schedule;Sensory;Shapes;Signal Transduction;Surface;Temporal Lobe;Testing;theories;Tissues;ventral visual stream;Visual;Visual Cortex;visual information;visual neuroscience;Visual Perception;visual processing;visual stimulus;Visual System;white matter

PROJECT_TITLE: Electrical stimulation to control feedback modulation of perception

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


PI_NAMEs: ESSERMAN, DENISE  (contact)

PROJECT_TERMS: Address;Aging;Algorithms;American;Applications Grants;Basic Science;Bayesian Method;Biometry;Biostatistical Methods;Biostatistics Core;Capsicum;Clinical;Clinical and Translational Science Awards;clinical implementation;Clinical Investigator;Clinical Research;Clinical Trials Design;Code;Collaborations;Complement;cost;Data;Data Science;design;Development;econometrics;efficacy evaluation;Elderly;Engineering;Ensure;Epidemiologist;Epidemiology;experience;Extramural Activities;Faculty;Funding;Genetic Complementation Test;Gerontology;Goals;Grant;Health Promotion;Home;implementation science;innovation;International;Intervention;Knowledge;Leadership;lectures;Machine Learning;Mediation;Medical;meetings;member;Mentors;Mentorship;Methodology;Methods;Mission;next generation;novel;novel strategies;older adult;Older Population;operation;Outcome;Outcome Assessment;Peer Review;Personal Satisfaction;Postdoctoral Fellow;Pragmatic clinical trial;primary outcome;Procedures;Productivity;programs;Publications;Quality Control;Reproducibility;Reproducibility of Results;Research;Research Design;Research Personnel;research study;Resources;Role;Science;Services;skills;Statistical Methods;Techniques;therapy design;Time;Training;Translational Research;Treatment Efficacy;web site;Work

PROJECT_TITLE: Core-002-Biostatistical Core


NIH_SPENDING_CATS: Genetics;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: PROJECT NARRATIVE Heterotopic ossification (HO) represents significant functional impairment, not only in genetic disorders like fibrodysplasia ossificans progressiva (FOP), but also in nongenetic conditions caused by invasive musculoskeletal procedures or trauma related to burns or major blast injuries as unfortunately occurs in modern conflicts. This project will redefine FOP as a cilia-mediated disease, put forth a new paradigm of cilia- mediated HO formation, and develop potential interventional targets based on this new mechanism. The proposed research is relevant to the part of the NIH mission that pertains to reducing illness and disability.

PI_NAMEs: WANG, HAITAO  (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: acquired heterotopic ossification;activin A;Activin Receptor;ACVR1 gene;Animal Model;ARL3 gene;Binding;Blast Injuries;BMP4;bone;Bone Morphogenetic Proteins;Burn injury;Cell Separation;Cell Surface Extensions;Cells;Chondrogenesis;Cilia;ciliopathy;Classification;Clinical;Clinical Treatment;combat;Complex;Connective Tissue;Data;deciduous tooth;Development;disability;Disease;experimental study;FK506 binding protein 5;Flare;Functional disorder;Functional impairment;Future;gain of function mutation;Genes;Genetic;Genetic Diseases;Goals;Heterotopic Ossification;Homeostasis;Human;human disease;Immobilization;In Vitro;in vivo;in vivo Model;Inherited;inhibitor;Injury;innovation;Intervention;Ligaments;Ligands;Link;lipid nanoparticle;loss of function;Mediating;Mesenchymal Stem Cells;Mission;Modeling;Modernization;Molecular;mouse model;Muscle;Musculoskeletal;mutant;Mutation;Nephronophthisis;non-genetic;novel;novel strategies;Orthopedic Surgery;Osteogenesis;Pathogenicity;Pathologic;Pathologic Processes;Pathway interactions;Patients;Pharmaceutical Preparations;Phosphorylation;Play;prevent;Prevention;Procedures;progressive myositis ossificans;receptor;Research;response;Role;Sensory;Signal Pathway;Signal Transduction;Signaling Protein;skeletal;Skeletal Development;Small Interfering RNA;soft tissue;spatiotemporal;stem cells;Structure;Surface;System;Tacrolimus Binding Proteins;Tendon structure;Testing;Therapeutic;tissue trauma;Tissues;Tooth Cell;Trauma;treatment strategy;United States National Institutes of Health

PROJECT_TITLE: The essential roles of primary cilia in heterotopic ossification

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: UNIVERSITY

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MISSISSIPPI

ORG_STATE: MS

PHR: PROJECT NARRATIVE Molecular models of biomolecular structures have led to a revolution in the way we understand and manipulate the molecules of life. However, due to limitations of current technology, large gaps remain in our understanding of the three-dimensional structure and dynamics of biomolecules and biomolecular complexes, including many critical to human health. Here, we propose to develop powerful and flexible technologies that allow researchers to measure biomolecular structures that change over time, as well as measure protein structures and complexes within mammalian whole blood.

PI_NAMEs: SHARP, JOSHUA S (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: adalimumab;Address;Amino Acids;Antibody Binding Sites;Antithrombin III;Area;Binding;Biological Sciences;biophysical properties;Blood;Blood Proteins;Buffers;Carbohydrate Chemistry;carbohydrate structure;Carbohydrates;cell injury;Cell model;Cells;chemical stability;Chromatography;Complex;Complex Mixtures;Computer Analysis;Computer Models;Computer Simulation;conformer;Coupled;Data;Development;Dose;dosimetry;dynamic system;Emerging Technologies;Engineering;Epitopes;experience;experimental study;Family;flexibility;Freezing;Generations;Health;Heparin;High Pressure Liquid Chromatography;high standard;Histones;Human;Hydrogen Peroxide;Hydrophobic Interactions;Hydroxyl Radical;Immune response;Immunoglobulin G;improved;In Situ;In Vitro;in vivo;Individual;innovation;Ion Exchange;Ions;Label;Life;Liquid Chromatography;Mass Spectrum Analysis;Measurement;Measures;mechanical force;Mediating;Membrane Proteins;Methods;Modernization;Modification;Molecular;Molecular Conformation;molecular mechanics;molecular modeling;Molecular Structure;Monoclonal Antibodies;mouse model;Mus;Organelles;Ovalbumin;Patients;Pharmaceutical Preparations;Pharmacology;Plasma;Play;Polysaccharides;Post-Translational Protein Processing;protein aggregation;Protein Analysis;protein complex;Protein Conformation;Protein Dephosphorylation;Protein Footprinting;Protein Isoforms;protein structure;Protein Structure Databases;Proteins;Proteome;reaction rate;Reagent;Reporting;Reproducibility;Research Personnel;Resolution;Role;Side;Site;Solvents;structural biology;Structure;Surface;System;Techniques;Technology;Testing;therapeutic protein;three dimensional structure;Time;Tissues;TNF gene;tool;tool development;Whole Blood;Work

PROJECT_TITLE: Molecular Structure Determination by Mass Spectrometry and Computational Modeling


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Breast Cancer;Cancer;Clinical Research;Dementia;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences;Patient Safety;Prevention;Women's Health Research

PI_NAMEs: SHAW, ALBERT C (contact)

PROJECT_TERMS: Address;Adipose tissue;Advisory Committees;age related changes;Age related macular degeneration;Aging;Alzheimer's Disease;Alzheimer's disease patient;American;Apoptosis;Applications Grants;Area;Award;Biometry;Biopsy;Biostatistics Core;Blindness;Breast Cancer Detection;Capsicum;cell injury;Clinical;clinical decision-making;cohort;Collaborations;Communicable Diseases;Core Grant;cost;cost effective intervention;COVID-19 diagnosis;Data;design;Development;Diabetes Mellitus;Diagnosis;Doctor of Medicine;Doctor of Philosophy;Elderly;Encapsulated;Enrollment;Ensure;Environment;Etiology;Extramural Activities;Fatty acid glycerol esters;Fostering;Funding;Future;Glaucoma;glial activation;Goals;Grant;Health Services;Human;human subject protection;Image;Immune system;immunosenescence;Inflammasome;Inflammatory;Infusion procedures;innovation;insight;Internist;Investments;Laboratory Research;Macular degeneration;Malignant Breast Neoplasm;Mammography;Medicine;Metabolic syndrome;Methodology;Microglia;Mid-Career Clinical Scientist Award (K24);Monitor;neuroinflammation;older adult;Older Population;older women;operation;Ophthalmology;Outcome;Pathogenesis;Pathology;Pathway interactions;Patients;Physicians;Prefrontal Cortex;Prevention;professor;programs;Publications;Recommendation;Recording of previous events;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;Research Proposals;Resources;Retina;Role;Safety;Scientist;single cell analysis;Study Section;success;Testing;Therapeutic Intervention;therapy development;Training;transcriptomics;United States National Institutes of Health;Vaccines;Vertebrates;vision science;Work;young adult

PROJECT_TITLE: Core 003 - Pilot Exploratory Studies Core


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: SACRAMENTO

ORG_NAME: CALIFORNIA DEPARTMENT OF PUBLIC HEALTH

PHR: CalFERT – RRT Maintenance – RFA-FD-23-019 Project Narrative The main goal of the proposed project is to continue maintenance of California’s best practices for a high-quality regulatory program to enhance food safety. This entails continued interagency collaboration, cooperation, and communication; maintenance and sustainment of conformance with the Manufactured Food Regulatory Program Standards (MFRPS); along with maintenance and sustainment of California’s Food Emergency Response Team. These activities are intended to further enhance California’s food safety program and its ability to respond to food and feed emergencies and better align it with a National Integrated Food Safety System.

PI_NAMEs: BOND, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: ANDREWS, THANH

PROJECT_TITLE: California Rapid Response Team 2023-2026 (CalFERT) - maintenance


NIH_SPENDING_CATS: Aging;Clinical Research

PI_NAMEs: FRIED, TERRI R. (contact)

PROJECT_TERMS: Address;Advisory Committees;Aging;aging related;American;Applications Grants;Area;Award;Basic Science;Biological;Capsicum;career development;Career Mobility;Clinical Research;cohort;Collaborations;collaboratory;design;Development;didactic education;Discipline;Doctor of Philosophy;education research;Educational Curriculum;Educational workshop;Elderly;Ensure;experience;Faculty;Financial Support;Fostering;Funding;Funding Agency;Funding Opportunities;Geriatrics;Goals;Growth;Home;Individual;interest;Journals;K-Series Research Career Programs;Knowledge;Leadership;leadership development;Learning;Medical;meetings;Mentors;Mentorship;Monitor;Outcome;Physicians;programs;Publications;Research;research and development;Research Personnel;Research Project Grants;Resources;Role;Services;skills;Source;success;Time;Training;translational pipeline;translational research program;translational study;Underrepresented Populations;Update;Work;Writing

PROJECT_TITLE: Research Education Core


ORG_CITY: LANSING

ORG_NAME: MICHIGAN STATE DEPT OF AGRICULTURE

PHR: MI RRT Project Narrative RFA-FD-23-019 The RRT Maintenance funding support will allow Michigan the opportunity to continue enhancing the MI RRT’s integrated strategy for a sustained, multidisciplinary, multi-agency approach to protect human and animal health through food and feed safety efforts. The Michigan Department of Agriculture and Rural Development (MDARD) has, given the diversity and scope the food and agricultural infrastructure, demonstrated that rapid response capacities for food and feed emergencies are best developed through the active engagement of individuals and task forces with a wide range of expertise to protect public health, the environment, and the economy. MDARD’s compliance and conformance with the Manufactured Food Regulatory Program Standards (MFRPS) and the Animal Food Regulatory Program Standards (AFRPS) provides a solid foundation for the MI RRT and help advance Michigan’s efforts to improve consistency and uniformity with federal standards and other state RRT programs; maintain the highest-quality investigation work; establish a basis for measuring and improving performance; share data and investigational findings with partners and industry; and develop and share best practices and other resources to support state and national response capacity and capability development to improve and influence the nationally integrated food safety system protection efforts.

PI_NAMEs: BONSKY, JENNIFER M;DEACON, BRADLEY NIELSEN (contact)

PROJECT_TITLE: Rapid Response Team (RRT) Maintenance TrackMichigan Department of Agriculture and Rural Development (MDARD)


ORG_CITY: FRANKFORT

ORG_NAME: KY ST CABINET/HEALTH/FAMILY SERVICES

ORG_STATE: KY

PHR: Kentucky Department for Public Health-Division of Public Health Protection & Safety  Food Safety Branch  Project Narrative/Intended Outcomes RE: Development and Maintenance of Human and Animal Food Rapid Response Teams (U2F) Clinical Trials Not Allowed (Funding Opportunity Announcement (FOA) Number RFA-FD-23- 019). The primary goal of the Kentucky Rapid Response Team is to minimize exposure to foodborne illnesses in the population. To meet this goal, the KY RRT will maintain and expand the current multiagency, interdisciplinary team to assist in all hazard responses including continued upkeep and development of our state Food Complaint System. This team will continue supporting the framework by providing training to state and local partners to increase their proficiency in event response.

PI_NAMEs: BELL, WILLIAM D (contact)

PROJECT_TITLE: Kentucky's Application for RRT


ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA STATE DEPARTMENT OF HEALTH

ORG_STATE: IN

PHR: Project Narrative: The Indiana Rapid Response Team (IN RRT) is dedicated to protecting the health of the public through efficient and effective response to human and animal food related emergencies. The mission is to improve and strengthen interagency communication, capacity, and capabilities through continual process improvements. Through enhanced training, collaboration, relationship building, and data sharing, our goals can be accomplished, and our contribution can lead to a more robust nationally integrated food safety system.

PI_NAMEs: YOUNG, JORDAN  (contact)

PROJECT_TITLE: Development and Maintenance of Human and Animal Food Rapid Response Teams for the State of Indiana


ORG_CITY: ATLANTA

ORG_NAME: GEORGIA STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: GA

PHR: Project Narrative Over the previous project periods the Georgia Food & Feed Rapid Response Team (GA RRT) has built upon the foundation and nationally demonstrated the effectiveness, success, and impact a RRT can have on contributing toward an integrated food safety system. This project continuation opportunity will allow Georgia to continually improve, maintain, and sustain the mission and resources of the GA RRT while building mutual reliance between partner agencies and established relationships. The team will continue to operate within the RRT Capacity Building Process and Mentorship Framework while innovating new ideas, tools, and resources to improve response outcomes and prevention efforts. To meet the goals and objectives the project will focus on developing metrics, measuring success and impact of RRT projects and operations as well as communicating impact with both internal and external stakeholders.

PI_NAMEs: NIELSEN, CRAIG  (contact)

PROJECT_TITLE: Georgia Department of Agriculture (GDA) Maintenance of Georgia's Human and Animal Food Rapid Response Team (RRT)


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Autism;Bioengineering;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: The goal of this project is to identify what is common, what varies, and what is abnormal in the human  brain structure by developing a transformative brain structural network descriptor with the help of massive  brain imaging data and computational model. The outcomes of this study are expected to have a broad and  highly positive impact on public health by advancing our fundamental understanding of brain development and autism spectrum disorders (ASD), and potentially informing better interventions for ASD and other  neurodevelopmental disorders.

PI_NAMEs: WANG, XIANQIAO  (contact)

PROGRAM_OFFICER_NAME: HARDY, KRISTINA KOREN

PROJECT_TERMS: Affect;Algorithmic Software;Architecture;autism spectrum disorder;Axon;Biomechanics;Brain;brain abnormalities;brain based;Brain Diseases;brain health;Brain imaging;brain magnetic resonance imaging;Cephalic;Child;Childhood;Clinical;Computer Models;Computer Simulation;computerized tools;Coupled;Data;data modeling;density;Descriptor;Development;Diagnosis;Electronic Medical Records and Genomics Network;fetal;Fiber;Goals;gray matter;Growth;Heterogeneity;Human;Image;Individual;infancy;innovation;Intervention;Knowledge;life span;Lifelong disability;Machine Learning;Magnetic Resonance Imaging;mechanical properties;Mechanics;Microscopic;model building;Modeling;multi-scale modeling;Neurodevelopmental Disorder;neuroimaging;novel;Outcome Study;Pattern;personalized predictions;Play;preservation;Process;Property;Public Health;Reporting;Reproducibility;Research;Role;Scientific Advances and Accomplishments;simulation;Structural defect;Structure;Surface;Testing;United States;white matter;Work

PROJECT_TITLE: SCH: Using Data-Driven Computational Biomechanics to Disentangle Brain Structural Commonality, Variability, and Abnormality in ASD


ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative This study will test strategies to reduce the use of unnecessary preoperative testing in patients undergoing low- risk surgery in Michigan. The information gained from this study will be invaluable in informing ongoing efforts to reduce low-value tests and treatments.

PI_NAMEs: DOSSETT, LESLY A (contact);NATHAN, HARI

PROGRAM_OFFICER_NAME: SIMPSON, MATTHEW

PROJECT_TITLE: De-implementation of Low-Value Testing in Patients Undergoing Low-Risk Surgery

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ORG_CITY: DES MOINES

ORG_NAME: IOWA STATE DEPT/ INSPECTIONS AND APPEALS

ORG_STATE: IA

PHR: The Iowa RRT continue and expand an all-hazards food and feed protection program in collaboration with other RRTs and the FDA. The mission of the Iowa RRT is to effectively respond to foodborne outbreaks and identify potential preventive practices to protect the food supply and consumer health nationally and globally.

PI_NAMEs: BOYD, MICHELLE L. (contact)

PROJECT_TITLE: Iowa Department of Inspection & Appeals RRT Maintenance


ORG_CITY: HARRISBURG

ORG_NAME: PENNSYLVANIA DEPARTMENT OF AGRICULTURE

PHR: PROJECT NARRATIVE Human food and animal feed emergencies, such as foodborne outbreaks or contamination events, can result in severe illness, long-term health effects, and even death. State, local, and federal food safety agencies all have an important role in identifying outbreaks and other emergencies, and rapidly responding with the goal of protecting public health. Rapid Response Teams (RRTs) are the current best practice to ensure states have trained staff who can work as coordinated multi-agency, multi- disciplinary teams to rapidly respond to and investigate foodborne outbreaks or other human food/animal feed emergencies.

PI_NAMEs: KLINE, KELLY  (contact);MORRIS, SHERI L

PROJECT_TITLE: RRT Maintenance Pennsylvania Department of Agriculture (PDA)


ORG_CITY: AUSTIN

ORG_NAME: TEXAS STATE DEPT OF HEALTH SERVICES

ORG_STATE: TX

PHR: TEXAS RAPID RESPONSE TEAM PROJECT NARRATIVE - RFA-FD-23-019 The Texas Rapid Response Team (TRRT) seeks to protect the citizens of Texas by prioritizing the safety of food, which may be compromised by various circumstances. The TRRT partners possess multi-disciplinary expertise and inter- jurisdictional authority to respond to complex foodborne illness investigations and emergency situations. The TRRT uses collaboration, information exchange, resource sharing, and relevant training to limit the adverse effects of contaminated and unsafe foods.

PI_NAMEs: COLEMAN, TISHARA  (contact)

PROJECT_TITLE: TX RRT


ORG_CITY: NASHVILLE

ORG_NAME: TENNESSEE STATE DEPARTMENT OF HEALTH

ORG_STATE: TN

PHR: Narrative: Tennessee Rapid Response Team Application 2023 The Tennessee Department of Health strongly desires to continue work with the Food and Drug Administration’s (FDA’s) Rapid Response Team (RRT) consortium. Since 2018 we have been a voluntary RRT member and recognize our mission is aligned with the stated purposes and objectives in the Development and Maintenance of Human and Animal Food Rapid Response Teams funding opportunity. We believe that becoming a funded RRT will improve our ability to fully develop the RRT structure, cultivating our existing outbreak response metrics. We have proposed a plan that we feel can enhance our ability to respond to human and animal food emergencies by completely enacting the FDA RRT framework in Tennessee. Our activities will foster a collaborative network between a range of programs in Tennessee and nationally.

PI_NAMEs: GARMAN, KATIE  (contact)


ORG_CITY: SAINT PAUL

ORG_NAME: MINNESOTA STATE DEPT OF AGRICULTURE

PHR: Minnesota RRT Project Narrative Funding provided through this Cooperative Agreement will ensure the continued development of a sustainable Rapid Response Team (RRT) that consists of expanding knowledge through data sharing, training, and exercises; strengthening the link between epidemiology, laboratory, and environmental health components of emergency response; and seeking out projects to enhance response capabilities. During this project period, the MDA RRT will conduct exercises with non- traditional response partners, complete RRT training with three FFSD inspection programs, and share project outcomes related to live animal market outbreaks, pesticide misuse data, and shopper history use impact. Continued funding will allow the MDA RRT to provide valuable input at a national level to the RRT Manual, CAT revisions, response-related procedures, and other national workgroups supporting RRT work.

PI_NAMEs: OPSAHL, DAN  (contact)

PROJECT_TITLE: Expanding Minnesota's Rapid Response Team through Outreach, Engagement, and Enhancements