NIH_SPENDING_CATS: Cancer

ORG_CITY: Rockville

ORG_NAME: FEDERATION OF AMER SOC FOR EXPER BIOLOGY

PHR: Program Director/Principal Investigator (Last, First, Middle): Tagliabracci, V.S.,/Yaffe, M. Narrative Protein phosphorylation, regulated by kinases, impacts growth and diseases like cancer and inflammation. The FASEB Conference on Protein Phosphorylation aims to share groundbreaking findings, support young investigators, and enhance our understanding of vital processes. By fostering collaboration, we strive to advance knowledge in this field, leading to better disease diagnosis, prevention, and treatment. OMB No. 0925-0001/0002 (Rev. 01/18 Approved Through 03/31/2020) Page Continuation Format Page

PI_NAMEs: TAGLIABRACCI, VINCENT SCOTT (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Acceleration;anti-cancer research;Antineoplastic Agents;Area;Attention;Automobile Driving;Biochemical;Biochemistry;Biological Process;Biology;career;career development;Career Mobility;Cells;Chemicals;Clinical;clinically relevant;Collaborations;Communication;Communities;Data;Development;Diabetes Mellitus;Diagnosis;Discipline;Disease;disease diagnosis;Drug Industry;Drug Targeting;Educational workshop;empowerment;Ensure;Environment;Event;Faculty;FDA approved;Fertilization;Fostering;Funding;Future;Goals;Growth;Health;Human;human disease;improved;Individual;Inflammation;innovation;insight;interdisciplinary approach;interest;Ireland;kinase inhibitor;Knowledge;Learning;Life;Lighting;Malignant Neoplasms;Medicine;meetings;Mentors;Mentorship;Metabolic syndrome;Methodology;Mission;Molecular;next generation;Oncology;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Play;Postdoctoral Fellow;posters;Prevention;Principal Investigator;Process;programs;Protein Engineering;Protein Kinase;Protein Kinase Protein Phosphorylation;Publications;Recording of previous events;Research;Research Personnel;Role;Science;Scientific Advances and Accomplishments;Scientist;Senior Scientist;Signal Transduction;Site;social;structural biology;Students;summer research;symposium;System;Systems Biology;targeted treatment;Technology;therapeutic development;Time;Translational Research;Underrepresented Minority;Underrepresented Populations;Walking;Work

PROJECT_TITLE: Protein Phosphorylation in Health and Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 PCRB-9 (J1)]


ADMINISTERING_IC: AT

ARRA_FUNDED: N

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Rehabilitation;Rehabilitation

ORG_CITY: ARLINGTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MARYMOUNT UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative This proposal of a one-day, virtual scientific workshop in October 2024 aims to increase knowledge of National Center for Complementary Integrative Health (NCCIH) funded complementary integrative medicine (CIM), support the representation of junior-level, underrepresented minority (URM) background scientists in the CIM workforce, and provide mentored research opportunities to utilize CIM in rehabilitation. Following the virtual workshop the fellows will attend the American Congress of Rehabilitation Medicine’s (ACRM’s) 2024 in-person annual meeting and be offered the opportunity for networking and research mentoring. The fellowship is geared specifically towards early career URM scientists; exposure to the most cutting-edge CIM science will encourage their interest in CIM and ultimately increase the number of promising URM scientists in the CIM field.

PI_NAMEs: HEYN, PATRICIA C. (contact);KIM, SONYA

PROGRAM_OFFICER_NAME: CHIDEYA-CHIHOTA, SEKAI RUTENDO

PROJECT_TERMS: Address;aging related disease;American;Applications Grants;Asian Women;Biofeedback;Brain Injuries;career;career development;clinical practice;Clinical Practice Guideline;Clinical Research;Collaborations;Congresses;design;Development;disability;Educational workshop;Ethnic Origin;Evaluation;Exposure to;Faculty Workshop;Feedback;Fellowship;Fostering;Funding;Goals;Grant;Health;healthy aging;heart rate variability;Hispanic Women;innovation;Integrative Medicine;interest;Justice;Knowledge;Leadership;Manuscripts;medical specialties;meetings;Mentors;Mentorship;minority scientist;multidisciplinary;National Center for Complementary and Integrative Health;Neurodegenerative Disorders;Outcomes Research;Peer Review;peer support;Persons;Physical Medicine;Play;Principal Investigator;process improvement;Publications;Race;recruit;rehabilitation research;Rehabilitation therapy;Research;Research Activity;Research Personnel;Research Project Grants;Research Training;Role;Science;Scientist;skills;social;success;symposium;Texas;Underrepresented Minority;United States National Institutes of Health;virtual;Work;Writing

PROJECT_TITLE: Complementary Integrative Rehabilitation Medicine: Cultivating Diversity in Research and Clinical Practice

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 AM (04)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_STATE: MD

PHR: PROJECT NARRATIVE Our proposal requests partial funding of the 2024 FASEB SRC on “B-Vitamins and One-Carbon Metabolism in Health and Disease” scheduled to take place August 11-16, 2024, at Sheraton Niagara Falls/Niagara Falls Convention Center, in Niagara Falls, NY. The goals of the meeting are to convene world experts as well as trainees in the area of B-Vitamins and One-Carbon Metabolism to present and discuss the latest, cutting-edge research and its implications for Public Health. This conference provides important educational and networking opportunities for the young investigators and trainees attending the meeting, including the opportunity to present their own research.

PI_NAMEs: KRUPENKO, NATALIA IVANOVNA (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: American;Analytical Chemistry;Animal Model;Anniversary;Area;Attention;Award;Biochemistry;Biological Sciences;Biology;cancer prevention;Carbon;career;career development;Cell model;Chronic Disease;Clinical Chemistry;clinical practice;Coin;Collaborations;Communicable Diseases;cost;Country;Dedications;Development;developmental disease;Diabetes Mellitus;Diagnosis;Disease;Education;Educational workshop;Epidemiologist;Epidemiology;epigenomics;evidence base;experimental study;falls;Feedback;Financial Support;Folic Acid;Fortification;Functional disorder;Funding;Future;Generations;Genetic;Genomics;Goals;graduate student;Growth and Development function;Health;Hour;Influentials;Inherited;Knowledge;Link;Malabsorption Syndromes;meetings;Metabolic Diseases;Metabolism;metabolomics;Molecular Biology;Neurologic;nutrition;nutrition related genetics;nutritional genomics;Obesity;Oral;Patient Representative;Perinatal;Physicians;population based;Postdoctoral Fellow;posters;postnatal;Public Health;Recreation;Relaxation;Request for Proposals;Research;research and development;Research Personnel;Schedule;Science;Scientist;Secure;Senior Scientist;Series;Side;Societies;Students;Supplementation;symposium;Travel;Underrepresented Minority;Update;Vitamin B 12;Vitamin B Complex;Vitamin B Deficiency;Work

PROJECT_TITLE: B Vitamins and One-Carbon Metabolism in Health and Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-7 (J3)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

PHR: The Training, Workforce Development and Diversity (TWD) Program Directors’ Meeting would provide ~500 program directors, administrators, and NIGMS program staff with 2.5 days of interactive sessions that advance best practices in developing a diverse biomedical workforce, and catalyze research training interchange. The overarching goal is to build upon and extend the meeting’s past success as the premier conference devoted to NIGMS TWD-funded institutional training program directors and administrators. High-quality interactive presentations of evidence-based research training practices and interventions would be combined with networking and exchange of ideas on 4 major proposed themes: 1) trainee and faculty wellness; 2) advancing research mentoring; 3) inclusive excellence including recruiting and admissions; and 4) promoting positive research laboratory culture.

PI_NAMEs: BERREBI, ALBERT S;GOMES, ALDRIN V.;LLOYD, JOYCE A. (contact);SEGER, YVETTE RENEE;SEPT, DAVID

PROGRAM_OFFICER_NAME: BROWN, ANISSA F

PROJECT_TERMS: Address;Administrator;Admission activity;American;biobehavior;Biology;Biomedical Research;bridge to the baccalaureate;bridge to the doctorate;CCL7 gene;Collaborations;Community Developments;design;evidence base;Faculty;Funding;Future;Goals;improved;Individual;Institution;Intervention;Laboratory culture;Laboratory Research;lectures;meetings;Mentors;National Institute of General Medical Sciences;Persons;Postdoctoral Fellow;posters;programs;Recommendation;recruit;Research;Research Personnel;Research Training;Societies;success;symposium;Text;Training;Training Programs;Underrepresented Populations;Woman;Workforce Development

PROJECT_TITLE: Biomedical Training Program Directors’ Conference

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TRN-Z (CF)]


ADMINISTERING_IC: AA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Hepatitis;Immunotherapy;Liver Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Substance Misuse

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: NARRTIVE Alcohol use can lead to alcoholic liver disease and it also has inhibitory effects on host defense mechanisms. In this project, we will evaluate a new hypothesis that alcohol use reprograms innate immune cells resulting in inappropriate responses to an infectious challenge, a term called “trained immunity”. We will test this hypothesis by using immune cells from blood of patients with alcohol-associated liver disease and perform mechanistic studies in mouse models of alcohol-induced liver disease first, by identifying epigenetic and metabolic drivers of alcohol-induced trained immunity and second, by testing potential interventions with the aim to restore alcohol- induced immune defects.

PI_NAMEs: SZABO, GYONGYI  (contact)

PROGRAM_OFFICER_NAME: LIN, LI

PROJECT_TERMS: Alcohol consumption;alcohol effect;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Blood;Bone Marrow;Cells;checkpoint receptors;Chronic;chronic alcohol ingestion;Clinical;Clinical Research;Data;Defect;design;epigenetic memory;Epigenetic Process;Event;exhaustion;experimental study;Gene Activation;Glycolysis;granulocyte-monocyte progenitors;HDAC9 gene;Hepatitis;Host Defense Mechanism;Human;Immune;immune checkpoint;Immune response;Immunity;Immunosuppression;Immunosuppressive Agents;in vivo;in vivo Model;Infection;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;insight;Integration Host Factors;Intervention;Investigation;Liver;Macrophage;Mediating;Metabolic;Metabolic Pathway;metabolic profile;Molecular;monocyte;mouse model;Mus;Natural Immunity;neutrophil;novel;Nutrient;Outcome;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Phenotype;phosphatidylinositol 3'-kinase-associated serine kinase;Population;programmed cell death protein 1;programs;Protein-Serine-Threonine Kinases;receptor;Repression;response;restoration;Role;sensor;Serine;Signal Transduction;single cell ATAC-seq;Small Nuclear RNA;stem cell population;Testing;Therapeutic Intervention;Training

PROJECT_TITLE: Alcohol and Monocyte Signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-Y (03)]


ADMINISTERING_IC: CA

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Climate-Related Exposures and Conditions;Clinical Research;Digestive Diseases;Hepatitis;Liver Cancer;Liver Disease;Prevention;Rare Diseases

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: Our highly significant proposed study will investigate the role of cyanotoxins--potent liver toxins produced by cyanobacteria, which are common environmental bacteria-- as an emerging risk factor for hepatocellular carcinoma, the major form of liver cancer. Our novel research may lead to improvements in liver cancer prevention and public health policies to improve environmental surveillance and testing and reducing exposure in communities.

PI_NAMEs: HERNANDEZ, BRENDA YUKARI (contact)

PROGRAM_OFFICER_NAME: STARKS, VAURICE

PROJECT_TERMS: Alcohols;Bacteria;bacteriome;Blood;carcinogenesis;carcinogenicity;case control;Central America;Cessation of life;chronic liver disease;cigarette smoking;cohort;Communities;Consumption;contaminated water;Custom;Cyanobacterium;Cyanotoxin;cylindrospermopsin;Data;Development;Diagnostic;disorder risk;DNA;drinking water;Ecosystem;Enzyme-Linked Immunosorbent Assay;Ethnic Population;Etiology;Eutrophication;exposed human population;Exposure to;Fatty Liver;Fibrosis;Food;Future;Gene Expression;Gene Expression Profile;Genes;global temperature;Growth;Guam;Guatemala;Hawaii;Health Policy;Heavy Drinking;Hepatitis B Virus;Hepatitis C virus;Hyperlipidemia;improved;Individual;Inflammation;Insulin Resistance;Investigation;Knowledge;lipid metabolism;liquid chromatography mass spectrometry;Liver;liver cancer prevention;Malignant neoplasm of liver;Measures;Metabolic;Metabolic syndrome;Metagenomics;microcystin;nano-string;nodularin;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Oral;oral diagnostics;Oral Ingestion;Patients;Plants;Policies;Population;Prevention;Primary carcinoma of the liver cells;Production;Property;Public Health;racial population;Recording of previous events;Research;Ribosomal RNA;Risk;Risk Factors;Role;Sampling;Serum;Smoking;Source;source localization;Testing;Toxin;tumor;Tumor Promotion;Tumor Tissue;uptake;Urine;Work

PROJECT_TITLE: Cyanobacteria, cyanotoxins, and liver cancer development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EPH-A (02)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Coronaviruses;Lung;Pulmonary Fibrosis

PHR: Project Narrative The 2024 FASEB Summer Research Conference, “The Lung Epithelium in Health and Disease,” brings together basic scientists, translational researchers and clinician investigators to discuss state-of-the-art approaches to understand the molecular mechanisms which underlie a broad range of respiratory diseases such as asthma, bronchopulmonary dysplasia, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, COVID-19, and others. The objectives of the conference are to 1) stimulate meaningful discussion, 2) facilitate collaboration, 3) establish new research directions and priorities, and 4) serve as a major forum for early stage investigators and trainees to present their work, facilitating development of the “next generation” of lung epithelial biologists. By linking the pathobiology of these disorders to normal lung development and lung cell differentiation, central themes will be identified to provide a mechanistic understanding of these diseases, and will accelerate progress toward the development of novel therapeutic approaches for a variety of lung diseases.

PI_NAMEs: SUCRE, JENNIFER MALCOLMSRYGLEY (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Acceleration;Alveolar;Applications Grants;Area;Asthma;Basic Science;Biology;Bronchopulmonary Dysplasia;career;Cell Differentiation process;cell growth;cell injury;cell type;Cells;Cellular biology;Chronic lung disease;Chronic Obstructive Pulmonary Disease;clinically relevant;Collaborations;Collection;Communication;Communities;Complement;COVID-19;COVID-19 pandemic;COVID-19 sequelae;Data;Development;Disease;disease model;Endothelial Cells;Environment;Epithelial Cells;Epithelium;Faculty;Feedback;Female;Fostering;Goals;gut-brain axis;Health;Homeostasis;idiopathic pulmonary fibrosis;Immune;improved;Industry;Injury;injury and repair;innovation;interdisciplinary collaboration;interest;International;intraepithelial;Knowledge;Link;Lung;lung development;Lung Diseases;lung health;meetings;Mentors;Mesenchymal;Minority;Mission;model organism;Modeling;Molecular;Molecular Biology;mouse model;multiple omics;National Heart, Lung, and Blood Institute;Natural regeneration;next generation;novel;novel therapeutic intervention;novel therapeutics;Occupations;Oral;Organ;Participant;Pathogenesis;Pathway interactions;Physiology;Play;posters;programs;Pulmonary Fibrosis;Pulmonary Surfactants;repaired;Research;Research Personnel;Resolution;Respiratory Disease;response;Role;SARS-CoV-2 infection;Scientific Advances and Accomplishments;Scientist;single cell analysis;Social Interaction;Students;summer research;surfactant;symposium;Techniques;Technology;transcriptomics;translational physician;translational potential;translational scientist;Translations;Underrepresented Minority;Woman;Work

PROJECT_TITLE: Lung Epithelium in Health and Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-L (J2)]


ADMINISTERING_IC: CE

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative The study advances the national priorities of identifying evidence-based primary prevention strategies for the pervasive problem of sexual violence among youth. Findings will advance the science on monitoring and evaluation strategies for emergent interventions that seek to create protective environments. Findings address a priority topic in health promotion and injury prevention in a population of high need.

PI_NAMEs: DECKER, MICHELE R. (contact)

PROJECT_TITLE: RFA-CE-20-001, Supplemental Research to Enhance Engagement & Measurement with Communities Disproportionately Affected by Sexual Violence


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: Narrative: By 12th grade, 10% of youth have been victims of sexual violence and much of this violence was committed by their adolescent peers. The SUSI campaign, a social marketing campaign to promote social norms that protect against sexual bullying and violence, has been funded by CDC's RPE program and implemented in Georgia High-Schools since 2014. The purpose of this project is to conduct formative and summative evaluation of the SUSI campaign's impact on sexual violence among high-school students, including sexual and gender minority youth.

PI_NAMEs: REIDY, DENNIS  (contact)

PROJECT_TITLE: CE20-001 Effectiveness Evaluation of `Step Up Step In' (SUSI): A Campaign to Promote Social Norms against Sexual Violence


ADMINISTERING_IC: EH

IC_NAME: NATIONAL CENTER FOR ENVIRONMENTAL HEALTH

ORG_CITY: NASHVILLE

ORG_NAME: TENNESSEE STATE DEPARTMENT OF HEALTH

ORG_STATE: TN

PHR: Project Narrative The Tennessee Department of Health strongly desires to continue work with the Centers for Disease Control and Prevention (CDC) and other EHS-Net consortium members to conduct practice- based research. Our mission is aligned with the stated purposes and objectives in the EHS-Net Practice Based Research to Improve Food Safety cooperative agreement and we have proposed projects that we feel can enhance foodborne disease investigation and food safety in Tennessee with generalizable outcomes for other jurisdictions. Our goal is to reduce morbidity and mortality associated with foodborne illness.

PI_NAMEs: DUNN, JOHN ROBERT (contact);IRVING, DOUGLAS

PROJECT_TITLE: RFA-EH-20-001: Environmental Health Specialist Network (EHS-Net) - Practice Based Research to Improve Food Safety


ADMINISTERING_IC: OH

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: People of color experience persistent disparities in liver disease outcomes in the U.S.; this project investigates how these disparities affect members of the Mount Sinai World Trade Center (WTC) General Responder Cohort. We will analyze for disparities in mortality, introduce a liver disease screening tool to Mount Sinai WTC Healthcare Program (WTCHP) providers, and study archived specimens to assess for toxins that were present in the WTC dust cloud. Results will provide data to inform CDC/NIOSH decisions about whether liver diseases meet criteria for WTC certification and will help identify and address any disparities that may exist among WTC General Responders.

PI_NAMEs: BRANCH, ANDREA D. (contact)

PROJECT_TITLE: Racial and Ethnic Disparities in Liver Disease in the WTC General Responder Cohort


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

ORG_NAME: UNIVERSITY OF TEXAS ARLINGTON

ORG_STATE: TX

PI_NAMEs: KERNSMITH, POCO  (contact)

PROJECT_TITLE: RFA-CE-20-001, Evaluating Practice-based Programs, Policies, and Practices from CDCs Rape Prevention and Education (RPE) Program: Expanding the Evidence to Prevent Sexual Violence - 2020


ORG_DEPT: OTHER BASIC SCIENCES

PHR: Project Narrative. This project will investigate how exposure to World Trade Center (WTC) dust during the 9/11 attacks impacts prostate cancer recurrence in First Responders with correlative mechanistic studies in relevant mouse genetic models. The results should aid in assessing whether responders with high exposure levels require increased active surveillance for evidence of biochemical recurrence and the presence of more aggressive disease.

PI_NAMEs: AARONSON, STUART A (contact);MULHOLLAND, DAVID ;TAIOLI, EMANUELA

PROJECT_TITLE: Assessing the impact of WTC dust exposure on prostate cancer recurrence


ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Disturbed sleep is a common symptom in the World Trade Center General Responder Cohort (WTCGRC) either due to obstructive sleep apnea (OSA) or from other comorbid conditions and can lead to poor cardiovascular health. In this project we will determine the risk of MACE in responders with OSA, association between hs-CRP, a biomarker of cardiovascular health, and disturbed sleep in WTCGRC subjects with and without OSA. In addition, we will test if the disturbed sleep clinical phenotype of OSA is associated with low arousal threshold and propensity to wakefulness.

PI_NAMEs: AYAPPA, INDU A;SUNDERRAM, JAG  (contact)

PROJECT_TITLE: Disturbed sleep and cardiovascular outcomes in World Trade Center Responders


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics;Human Genome;Osteoporosis

ORG_CITY: NEW ORLEANS

ORG_DEPT: PATHOLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative The long term goal of this study is to develop safer and effective therapeutic approach for bone loss caused by excessive osteoclast (OC) differentiation implicated in many metabolic bone diseases (such as osteoporosis). The study will characterize the function of key epigenetic factor Cbx3 in interacting with C/EBPα to mediate OC formation with implication in bone homeostasis and bone loss. Insights gained from this study will not only address the basic scientific question about epigenetic regulation of gene expression in OC biology, but also will provide the foundation for the ultimate goal of facilitating the design of safer and novel therapeutic approach for osteolytic diseases.

PI_NAMEs: LI, YI-PING  (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Address;Binding;Binding Proteins;Binding Sites;Biology;bone;Bone Diseases;bone loss;Cathepsin C;cathepsin K;CCAAT-Enhancer-Binding Protein-alpha;ChIP-seq;Chromatin;Complex;conditional knockout;Cre lox recombination system;Data;design;Development;Disease;Epigenetic Process;epigenetic regulation;Exhibits;Female;FOS gene;Foundations;gain of function;Gene Expression;Gene Expression Regulation;Gene Silencing;Genes;Genetic Transcription;genome-wide;Goals;Heterochromatin;histone methylation;Homeostasis;Homologous Gene;Immunoprecipitation;insight;Knockout Mice;loss of function;male;Mass Spectrum Analysis;Mediating;Metabolic Bone Diseases;Modeling;Modification;Molecular;monocyte;mouse model;Mus;new therapeutic target;novel therapeutic intervention;osteoclastogenesis;Osteoclasts;Osteolytic;Osteoporosis;Ovariectomy;overexpression;Pathologic;Pattern;Phenotype;Physiological;prevent;promoter;Proteins;Regulation;Role;Signal Transduction;Skeletal bone;Skeletal Development;Testing;therapeutically effective;transcription factor;transcriptome sequencing;Transgenic Organisms

PROJECT_TITLE: Mechanistic basis of the role of Cbx3 in negatively regulating osteoclast differentiation through epigenetic modification

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: JOHNSON CITY

ORG_NAME: EAST TENNESSEE STATE UNIVERSITY

PHR: Project Narrative Invasive fungal infections are a serious public health issue which are associated with unacceptably high mortality rates, suggesting modern therapies are insufficient. One obstacle in developing new therapies is an incomplete understanding of complex host-pathogen interactions during fungal infection, including the role of the recently characterized behavior of neutrophil swarming. This research will utilize novel microscale tools to elucidate key aspects of neutrophil swarming biology, in order to lay the foundation for leveraging swarming function in the design of new therapeutic strategies.

PI_NAMEs: HOPKE, ALEX  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Address;anti-fungal agents;Antifungal Therapy;Automobile Driving;Behavior;Biological Assay;Biology;Candida albicans;career;Cells;Chemicals;combat;Complex;Containment;CSF3 gene;cytokine;Data;Death Rate;Decision Making;design;Development;Devices;Elements;Ensure;Event;Faculty;fighting;Foundations;fungus;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Host Defense;Human;Hyphae;Immune;Immune system;Immunity;improved;Individual;Infection;infection risk;Inflammation;inhibitor;Investigation;Knowledge;Mediating;Mediator;Mentors;Microbial Biofilms;microorganism;Mission;Modernization;Molecular;Molecular Analysis;Molecular Probes;Morbidity - disease rate;Morphology;mortality;Mycoses;National Institute of Allergy and Infectious Disease;Natural Immunity;neutrophil;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;pathogen;pathogenic fungus;pathogenic microbe;Pathway interactions;patient population;Patients;Pattern;Phase;Positioning Attribute;programs;Public Health;Publishing;receptor;Receptor Cell;recruit;Research;research faculty;response;Risk;Role;Scientist;Signal Pathway;Signal Transduction;skills;targeted treatment;tenure track;Therapeutic;therapeutic development;therapeutic target;tool;Visual;Work

PROJECT_TITLE: Characterization of Neutrophil Decision making during Swarming to Fungal Pathogens

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_NAME: FRIENDS RESEARCH INSTITUTE, INC.

PHR: Project Narrative Trans women (TW) achieve suboptimal advancement through the HIV Care Continuum, including poor HIV healthcare utilization, retention in HIV medical care, and rates of viral suppression and these issues are exacerbated by comorbid conditions such as substance use disorder. This application will conduct a comparative-effectiveness research trial with a comprehensive economic evaluation of two HRSA-funded demonstration projects, to identify the optimal intervention for improving rates of viral suppression among TW living with HIV. The public health significance is profound, as comparative- and cost-effectiveness research trials are critical steps in the development and adoption of scalable and effective HIV care intervention, especially among key populations that rely on service provision in community-based settings.

PI_NAMEs: MURPHY, SEAN M.;REBACK, CATHY J (contact)

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adoption;Age;arm;Behavior;Caring;Characteristics;Communities;comorbidity;comparative effectiveness;Comparative Effectiveness Research;Continuity of Patient Care;cost;cost effective intervention;cost effectiveness;Cost Effectiveness Analysis;Cost effectiveness research;County;design;Development;Distal;Drug Screening;Drug usage;economic evaluation;Education;effective intervention;Effectiveness;Effectiveness of Interventions;Emergency department visit;Epidemic;Equipment and supply inventories;ethnic identity;experience;Food;Funding;girls;Goals;Health;health belief;Health Care Costs;Health Care Sector;health care service;health care service utilization;health disparity populations;HIV;HIV diagnosis;HIV Infections;HIV Seropositivity;HIV/AIDS;Housing;Imprisonment;improved;Individual;Inpatients;Insurance;Insurance Carriers;Intervention;intervention effect;Legal;Link;Location;Los Angeles;Measures;Medical;Modeling;National Institute of Drug Abuse;Outcome;overdose death;Participant;peer;Policy Maker;Population;population health;Population Intervention;Poverty;Primary Care;Productivity;Provider;Public Health;Public Policy;Quality of life;Quality-Adjusted Life Years;Race;Randomized;relative effectiveness;Research;Resources;response;safety net;Screening Result;secondary outcome;Self Efficacy;Service provision;Services;Sexual and Gender Minorities;social;social cognitive theory;social determinants;Social support;structural health determinants;Subgroup;Substance Use Disorder;System;Text;Text Messaging;theories;Time;transgender women;treatment adherence;treatment as usual;United States Health Resources and Services Administration;United States National Institutes of Health;Urine;Viral;women of color

PROJECT_TITLE: Comparative- and cost-effectiveness research determining the optimal intervention for advancing transgender women living with HIV to full viral suppression

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: INDIANAPOLIS

ORG_NAME: RLR VA MEDICAL CENTER

ORG_STATE: IN

PHR: PROJECT NARRATIVE Aging is a major risk factor for alcoholic liver diseases and is associated with gradual alteration of liver structure and function as well as significant changes in liver cells including liver sinusoidal endothelial cells. The health relatedness of this grant proposal is that effective treatments are lacking for alcoholic liver diseases that cause vascular dysfunction and senescence in the liver. The rationale for our research is that the successful completion of the studies can ultimately be expected to provide a greater understanding of the functional role of non-coding RNA (ncRNA) mediated endothelial dysfunction and cellular senescence during the progression/recovery of alcoholic liver injuries and increase opportunities for the development of novel treatment paradigms for the management of alcoholic liver diseases.

PI_NAMEs: MENG, FANYIN  (contact)

PROJECT_TERMS: Acceleration;Aging;alcohol-related injury;Alcoholic Liver Diseases;Alcoholic steatohepatitis;Alcohols;Animal Diseases;Applications Grants;Cell Aging;cell growth regulation;cell injury;Cells;chronic alcohol ingestion;chronic liver disease;chronic liver injury;Circulation;Cirrhosis;Clinical;CRISPR/Cas technology;Data;Development;E2F transcription factors;effective therapy;Endothelial Cells;endothelial dysfunction;endothelial stem cell;Endothelium;Endotoxins;Ethanol;Ethanol dependence;Ethanol Metabolism;evidence base;expectation;extracellular vesicles;fatty liver disease;feeding;Fibrosis;Foundations;Functional disorder;Gene Expression;Genes;Genetic Transcription;Goals;Health;Hepatic;hepatic sinusoid;Hepatocyte;Human;IGFBP3 gene;in vivo;Inflammation;Inflammatory;Intervention;Knockout Mice;Link;Lipopolysaccharides;Literature;Liver;liver development;Liver diseases;Liver Fibrosis;liver injury;Mediating;Mediator;MicroRNAs;Morbidity - disease rate;mortality;Mus;novel;Outcome;Pathway interactions;Patients;Phenotype;Plasminogen Activator Inhibitor 1;Play;PPAR alpha;prevent;Prevention strategy;Primary carcinoma of the liver cells;problem drinker;Prognosis;Recovery;Research;Risk Factors;Role;senescence;Severities;SIRT1 gene;Specimen;Stimulus;Structure;Therapeutic Effect;Tissues;TLR4 gene;TNF gene;TP53 gene;treatment strategy;United States;Untranslated RNA;Vascular Diseases;Veterans

PROJECT_TITLE: Functional characters of non-coding RNAs in alcoholic liver injury


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Regenerative Medicine;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: NARRATIVE It has been demonstrated that the human lumbosacral spinal cord can be neuromodulated with epidural (ESS) and transcutaneous (TSS) spinal cord stimulation to enable recovery of standing and volitional control of the lower limbs after complete motor paralysis. The work proposed herein will examine and identify the distinct and potentially overlapping electrophysiological mechanisms underlying TSS and ESS, and define how these approaches determine functional outcomes. We will also directly compare the immediate and delayed training effects of TSS and ESS on the ability to maintain self-assisted standing after SCI, and determine potential biomarkers associated with delayed neurophysiological changes that are thus indicative of plasticity.

PI_NAMEs: SAYENKO, DIMITRY  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Address;Autonomic nervous system;Biological Markers;Biometry;Bladder;Body Weight;Brain;Cardiovascular system;Clinical;clinical application;Clinical Research;Clinical Trials;combinatorial;Communities;cost;cost effective;Data;Development;Effectiveness;Electrophysiology (science);Environment;functional gain;functional improvement;Functional Magnetic Resonance Imaging;functional outcomes;Goals;Human;improved;Individual;individual response;Injury;Intervention;Leg;Lower Extremity;Measurement;Measures;Methodist Church;Methods;minimally invasive;Modality;Modeling;Motor;Motor output;motor rehabilitation;Movement;multidisciplinary;Muscle;Musculoskeletal Equilibrium;Nature;Nerve Regeneration;Nervous System Physiology;neural;neural network;Neural Pathways;neuroimaging;Neuronal Plasticity;neurophysiology;neuroregulation;Neurosciences;Neurostimulation procedures of spinal cord tissue;neurosurgery;Outcome;Paralysed;Participant;Patient Selection;Patients;Performance;Personal Satisfaction;Phase;Physiological;Population;Positioning Attribute;Posture;potential biomarker;Pre-Clinical Model;Protocols documentation;Recovery;Recovery of Function;Regimen;Rehabilitation therapy;relative effectiveness;Research;Research Institute;Research Methodology;Resources;response;Rest;restoration;Severities;Signal Transduction;Site;Spinal;Spinal Cord;Spinal cord injury;spinal nerve posterior root;Stimulus;Techniques;Therapeutic;Training;Transcutaneous Electric Nerve Stimulation;Weight-Bearing state;Work

PROJECT_TITLE: Harnessing Neuroplasticity of Postural Sensorimotor Networks Using Non-Invasive Spinal Neuromodulation to Maximize Functional Recovery After Spinal Cord Injury

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

ORG_CITY: ROCHESTER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Public Health Relevance Statement  The overall objective of this renewal application is to safeguard and promote the frog Xenopus laevis, as an important non-mammalian comparative model for biomedical research in general as well as for fundamental and medical immunology. We are proposing to continue the maintenance and the development of this unique non-mammalian research resource facility that includes inbred and transgenic animals, reagents, protocols, information and training opportunity for biomedical research for the benefit of the whole scientific community.

PI_NAMEs: ROBERT, JACQUES  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: 3' Untranslated Regions;Amphibia;Animal Experiments;Animals;Area;Awareness;Biological Metamorphosis;Biomedical Research;CD4 Positive T Lymphocytes;Cell Culture System;Cell Line;cell type;Cells;Communicable Diseases;Communities;comparative;cost effective;cost effectiveness;CRISPR/Cas technology;Dedications;Development;Developmental Biology;Embryonic Development;Emerging Technologies;Endocrine disruption;Engineering;Environment;Evolution;Exposure to;Fostering;Funding;Future;Gene Expression;Gene Modified;Gene Transfer Techniques;Genes;Genetic;genetic manipulation;genetic resource;genome annotation;genome editing;genome resource;Goals;Growth;Health;Host Defense;Human;Immune;Immune system;Immunity;Immunobiology;immunodeficiency;Immunologics;Immunology;Immunotoxicology;improved;In Vitro;in vivo;Inbred Strain;Inbreeding;Infection;Inflammation;innovation;insight;interest;International;Investigation;Japan;Knock-in;knockout gene;Laboratories;lentivirally transduced;Life;loss of function;Macrophage;Maintenance;Malignant Neoplasms;Mammals;Mediating;Medical;meetings;Methodology;Methods;Modeling;Monoclonal Antibodies;Mus;Mycobacterium abscessus;Mycobacterium tuberculosis;new technology;non-tuberculosis mycobacteria;novel strategies;Organ;Paper;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Phylogeny;Physiology;Postembryonic;preservation;Productivity;Protocols documentation;public health relevance;Rana;Reagent;Recombinants;Reporter;Reporter Genes;Research;Research Personnel;Resources;Risk;RNA Interference;Scientist;stem;Students;Study models;synergism;System;T-Lymphocyte;Tadpoles;Techniques;Technology;Thymus Gland;Tissues;tool;Training;training opportunity;Transfection;Transgenic Animals;Transgenic Organisms;tumor;United States National Institutes of Health;vector;Vesicular stomatitis Indiana virus;Viral;Water Pollutants;web site;welfare;Work;Xenopus;Xenopus laevis

PROJECT_TITLE: A Xenopus Laevis Research Resource for Immunobiology


ADMINISTERING_IC: DE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Immunotherapy;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative The spread of oral cancer is deadly. We will determine how oral cancer cells manipulate their surroundings so they can spread to the lungs and avoid the immune system. The results of these studies will help determine patients at increased risk of cancer expansion and identify new ways to target high risk oral cancer.

PI_NAMEs: ALEMAN, JOHN  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Affect;anti-tumor immune response;Atomic Force Microscopy;cancer cell;cancer risk;cancer stem cell;cancer type;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Communication;Cell Line;Cells;checkpoint therapy;Clustered Regularly Interspaced Short Palindromic Repeats;Collagen;Collagen Gene;Collagen Type I;Consensus;crosslink;Data;Dependence;Deposition;Disease;Distant Metastasis;Drops;Esophagus;Exclusion;Extracellular Matrix;Failure;Flow Cytometry;Genes;Genetic;Goals;high risk;Human;Immune;Immune checkpoint inhibitor;Immune system;Immunocompetent;Immunomodulators;improved;In Vitro;in vivo;Infiltration;inhibitor;insight;Integrin Binding;Integrins;Invaded;Investigational Therapies;Keratin;Knock-out;KRASG12D;Laboratories;Laminin;Lung;Lymphocyte;Lymphocyte Count;Lymphocytic Infiltrate;Malignant Breast Neoplasm;Malignant Epithelial Cell;malignant mouth neoplasm;Malignant Neoplasms;Measures;Mediating;Metastatic Neoplasm to the Lung;Metastatic Squamous Cell Carcinoma;migration;Modeling;Motility;mouse model;mouth squamous cell carcinoma;Mus;Mutation;Neoplasm Metastasis;Non-Small-Cell Lung Carcinoma;Nonmetastatic;Outcome;Patient Care;Patients;Primary Care;Primary Neoplasm;Production;Prognostic Factor;Prognostic Marker;Proteins;Regulation;response;Risk;Sampling;Signal Transduction;Squamous cell carcinoma;standard of care;stem cell expansion;stem cells;stemness;success;Survival Rate;targeted treatment;Testing;TGFB1 gene;therapeutic target;trafficking;trait;transcriptome sequencing;Transforming Growth Factor beta;Transplantation;tumor;tumor microenvironment;Tumor-Infiltrating Lymphocytes

PROJECT_TITLE: Assessing TGF Beta1-Mediated ECM Remodeling in Metastatic Oral Squamous Cell Carcinoma

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Prevention

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because human Noroviruses (hNoV) are the leading cause of viral gastroenteritis and food-borne disease worldwide. NIAID/NIH has designated Caliciviruses (including hNoV) as an “Emerging Infectious Disease Category B Priority Pathogen.” Currently, there are no antiviral drugs or vaccines approved for the treatment of hNoV infections, and therefore, the goal of this proposal is to design and develop a series of specific and safe small-molecule inhibitors targeting a critical viral protein required for virus replication and thus limit or eliminate hNoV infections in immunocompromised patients.

PI_NAMEs: KOVARI, LADISLAU CHRISTOPHER;SCHINAZI, RAYMOND FELIX (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: 3-Dimensional;Acute;analog;Anti-viral Agents;anti-viral efficacy;antiviral drug development;aqueous;Benchmarking;Binding;Biocompatible Materials;Biological Assay;Biological Availability;Calicivirus;Category B pathogen;Cells;Cessation of life;Characteristics;Child;Chronic;chronic infection;Complex;congenital immunodeficiency;Coronavirus;Crystallography;cytotoxicity;Data;design;disease model;drug candidate;drug efficacy;Drug Efflux;Drug resistance;Drug Targeting;economic cost;efficacy study;efficacy testing;Elderly;Emerging Communicable Diseases;Enterovirus;Enzyme Kinetics;Enzymes;Face;Family;FDA approved;foodborne illness;Gastroenteritis;Goals;Half-Life;Health Care Costs;Hepatitis C virus;HIV-1;Hospitalization;Human;Immunocompromised Host;immunodeficient mouse model;Infection;inhibitor;innovation;Intervention;Intestines;Investigational New Drug Application;Lead;Libraries;Life;Liver;Liver Microsomes;Medical;member;meter;milligram;Modeling;molecular modeling;Morbidity - disease rate;mortality;mouse model;Mus;nanomolar;National Institute of Allergy and Infectious Disease;Norovirus;nucleoside analog;Nucleosides;Oral;Outcome;Pathology;Peptide Hydrolases;peptidomimetics;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phase;Plasma;Polyproteins;Population;preclinical study;Prevention;Prevention approach;Production;Protease Inhibitor;Public Health;Recombinant Proteins;Replicon;Research;Resistance;Resolution;Risk;Role;Series;small molecule;small molecule inhibitor;Solubility;Speed;Structure;System;targeted agent;Testing;Therapeutic Index;Transplant Recipients;United States;United States National Institutes of Health;vaccine development;Vaccines;Valine;Viral;Viral Gastroenteritis;Viral Proteins;virology;Virus Replication;ZIKA

PROJECT_TITLE: Anti-norovirus protease inhibitors for immunocompromised patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-B(82)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: LOS ANGELES

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Narrative Darobactin A is a newly discovered antibiotic that is active against dangerous Gram-negative pathogenic bacteria. We propose to study darobactin biosynthesis and to use a combination chemical and enzymatic methods to prepare novel darobactin analogs. Compounds of this kind could potentially be developed into new drugs to treat multi-drug resistant infections.

PI_NAMEs: HARRAN, PATRICK G. (contact);LIU, HUNG-WEN

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Anabolism;analog;Animal Model;Antibiotics;Bacterial Outer Membrane Proteins;beta barrel;beta pleated sheet;Binding;C-terminal;Catalysis;chemical synthesis;Chemicals;commensal bacteria;crosslink;Cyclic Amino Acids;Dangerousness;Data;Dipeptides;Electronics;Electrons;Engineering;Enzymatic Biochemistry;Enzymes;Esters;experimental study;Goals;Human;Hydrolysis;In Vitro;Infection;Iron;Knowledge;Ligation;Methodology;Methods;mimetics;Modification;Molecular Chaperones;Multi-Drug Resistance;Natural Products;Nematoda;novel;novel antibiotic class;novel therapeutics;Operon;Outcome;pathogen;pathogenic bacteria;Pathway interactions;Pattern;Peptide Antibiotics;Peptides;Photorhabdus;Process;programs;Proline;Proteins;Reaction;Recombinants;reconstitution;Series;stable plasma protein solution;Sulfur;Supporting Cell;symbiont;Titrations

PROJECT_TITLE: Chemoenzymatic Synthesis of Darobactin Antibiotics


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Acute Respiratory Distress Syndrome;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Antimicrobial Resistance;Brain Disorders;Dementia;Infectious Diseases;Lung;Neurodegenerative;Neurosciences;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_CITY: MOBILE

ORG_NAME: UNIVERSITY OF SOUTH ALABAMA

ORG_STATE: AL

PHR: PROJECT NARRATIVE Bacterial pneumonia caused by the highly antibiotic resistant ESKAPE pathogens is an important cause of acute lung injury, sepsis, and long-term sequelae collectively referred to as post-intensive care syndrome (PICS). Despite the severity and prevalence of these debilitating conditions, there are currently no specific therapies available to facilitate treatment and augment patient recovery. Thus, the goal of this proposal is to test the potentially transformative concept that the amyloid precursor protein (APP) modulates PMN NETosis and degranulation to limit lung damage in response to lung infection, and leverage these findings towards discovery of novel targets to treat pneumonia, sepsis, and PICS.

PI_NAMEs: AUDIA, JONATHON PETER (contact);BARRINGTON, ROBERT A

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Acute;Acute Lung Injury;Adoptive Transfer;Alzheimer's disease pathology;Amyloid;Amyloid beta-Protein;Amyloid beta-Protein Precursor;amyloid peptide;Animals;anti-microbial peptide;Antibiotic Resistance;antimicrobial;Bacterial Meningitis;Bacterial Pneumonia;biobank;Biological Assay;Biological Markers;Biological Process;Biology;Blood;Bone Marrow;Cell Culture Techniques;Cell Physiology;Cerebrospinal Fluid;Chemotaxis;Chronic;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Critical Illness;Cystic Fibrosis;cytokine;Cytoplasmic Granules;cytotoxic;Data;Diagnostic;drug resistant pathogen;ESKAPE pathogens;Etiology;Exhibits;experimental study;extracellular;Functional disorder;fungus;Future;Goals;Immune;improved outcome;In Vitro;Incidence;Infection;Infection Control;Inflammation;Inflammatory;Innate Immune Response;innovation;Intensive Care;Intensive Care Units;Invaded;Klebsiella pneumoniae;Knock-out;Knockout Mice;Left;Link;long-term sequelae;Lung;Lung infections;lung injury;Measures;Mediating;Modeling;Molecular;monocyte;mortality;Multiple Organ Failure;Mus;Natural Immunity;Neurobiology;Neurocognitive;Neuroglia;neurotoxic;neutralizing antibody;neutrophil;Neutrophil Activation;Neutrophil Infiltration;novel;Organ;Organ failure;organ growth;outcome prediction;pathogen;pathogenic bacteria;Pathology;Patients;Peripheral Blood Mononuclear Cell;Phagocytosis;Physiological;Plasma;Play;Pneumonia;pneumonia model;pneumonia treatment;Predisposition;Prevalence;Production;protein expression;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Pseudomonas aeruginosa pneumonia;Publishing;Quality of life;Recombinants;Recovery;Reporter;Respiratory Failure;response;Role;Sampling;Sepsis;Severities;Staphylococcus aureus;Survivors;Syndrome;Testing;Therapeutic;Tissues;Virulence Factors;Virus;Work

PROJECT_TITLE: The amyloid precursor protein protects against acute lung injury

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Hematology;Neurosciences;Pain Research;Prevention;Rare Diseases;Sickle Cell Disease

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE Pain, the most common complication of sickle cell disease, causes significant patient suffering and lacks effective treatments. This proposal will derive and preliminarily determine whether a biomarker that reflects the activities of the inflammatory and regulatory components of the immune system is correlated with the heterogeneity of pain seen in patients with sickle cell disease. This biomarker could be used in clinical trials of novel pain treatments.

PI_NAMEs: BRANDOW, AMANDA M (contact)

PROGRAM_OFFICER_NAME: ARUDCHANDRAN, RAMACHANDRAN NMN

PROJECT_TERMS: Acute Pain;Affect;beta Globin;Biological Assay;Biological Markers;Biological Response Modifiers;Biology;Cells;chemokine;Chronic;Clinical;clinical heterogeneity;clinical pain;Clinical Trials;cohort;Complex;Complication;cytokine;Data;debilitating pain;differential expression;effective therapy;experience;Genes;Genetic Transcription;genome-wide;Goals;Health;health care service utilization;Hemoglobinopathies;Hemolysis;Heterogeneity;Immune;immune modulating agents;Immune system;immunoregulation;inclusion criteria;indexing;individual variation;Inflammation;Inflammation Mediators;Inflammatory;inflammatory milieu;Inflammatory Response;Inherited;inter-individual variation;Link;Lipids;Measures;multidisciplinary;Mutation;novel;Ontology;Pain;Pain management;Pain Measurement;Pain Research;Pathway Analysis;Patient Outcomes Assessments;Patients;Pattern;Persons;Phase;Plasma;Population;prognostic;Prognostic Marker;prognostication;prospective;Recurrence;Recurrent pain;Regulator Genes;Reperfusion Injury;Reporter;Research;response;Sickle Cell Anemia;Sickle Hemoglobin;Signal Transduction;Testing;Training;Transcript;United States;Validation;Work

PROJECT_TITLE: The Inflammatory Index as a Biomarker for Pain in Patients with Sickle Cell Disease


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Infectious Diseases;Kidney Disease;Neurodegenerative;Organ Transplantation;Transplantation

PHR: PROJECT NARRATIVE Older kidney transplant (KT) recipients are at higher risk of cognitive and physical function decline, Alzheimer's Disease (AD), and frailty compared to their healthy community-dwelling older adult counterparts; post-transplant cytomegalovirus (CMV) infection and subsequent inflammation may play a critical mechanistic role, and is a potentially preventable determinant of cognitive and physical function decline and frailty in older adults. This proposal aims to understand the effect of CMV, CMV cell mediated immune reconstitution (CMV-CMI), and inflammation on decline in cognitive and physical function, AD, and frailty among older KT recipients. Our exploration of CMV, CMV-CMI, cognitive and physical function decline in a novel population of older KT recipients will directly benefit this uniquely vulnerable population and guide their physicians by helping to inform risk prediction, guide clinical decision making, and possibly even offer clues into underlying physical and cognitive reserve mechanisms that may relate to cognitive decline, AD and frailty among healthy community-dwelling older adults.

PI_NAMEs: ABIDI, MAHEEN ZEHRA (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Acceleration;Address;Admission activity;Adult;aged;Aging;aging related;Alzheimer's Disease;Area;Automobile Driving;career;career development;Cells;Cellular Immunity;chemokine;Chronic;chronic infection;clinical decision-making;Cognition;Cognitive;cognitive function;cognitive reserve;cognitive testing;cohort;Colorado;Communities;cytokine;Cytomegalovirus;Cytomegalovirus Infections;Dementia;design;Development;Development Plans;Diagnosis;Disease;effective therapy;Elderly;Enrollment;Epidemiology;experience;follow-up;frailty;functional decline;Funding;Gait speed;Geriatrics;Gerontology;Goals;Health;Health Priorities;high risk;Immune;immune reconstitution;Immune response;Immune system;Immunologic Stimulation;Immunology;immunosenescence;Immunosuppression;Impaired cognition;improved;Inflammation;Inflammatory;inflammatory marker;innovation;International;Investigation;Kidney Diseases;Kidney Transplantation;Knowledge;Link;Measures;Mediating;Mentors;Methodology;Mission;novel;older adult;Older Population;Outcome;Patients;Phenotype;Physical Function;Physical Performance;Physicians;Physiological;Plasma;Play;Population;post-transplant;Prophylactic treatment;reactivation from latency;reconstitution;Research;Research Design;Research Personnel;Research Project Grants;Research Training;response;Risk;risk prediction;Role;Secondary to;seropositive;Speed;stressor;Testing;Time;Trail Making Test;Training;Transplant Recipients;United States National Institutes of Health;Vascular Dementia;Viral;Virus Diseases;Virus Replication;Vulnerable Populations

PROJECT_TITLE: CMV and CMV-Immune Responses in Geriatric Conditions Post-Kidney Transplant (CMV-GeriKT)

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


ORG_DEPT: SURGERY

PHR: OVERALL – NARRATIVE Ischemia-reperfusion injury (IRI) limits the success of orthotopic liver transplantation in patients with end-stage liver disease and those with tumors of hepatic origin. By using established mouse models of IRI, and analyzing human liver transplants, this translational Program Project seeks to address unmet scientific and clinical needs in the field of organ transplantation. The results have the potential to alter clinical paradigms by identifying the continuum of innate/adaptive immune phenotypes that can be used to select, monitor, and refine the practice of therapeutic interventions against IRI in transplant patients.

PI_NAMEs: KUPIEC-WEGLINSKI, JERZY W (contact)

PROGRAM_OFFICER_NAME: KEHN, PATRICIA J

PROJECT_TERMS: Acute;Address;Alternative Splicing;Anti-Inflammatory Agents;Automobile Driving;Biostatistics Core;CEACAM1;Cessation of life;Chronic;Clinical;cofactor;Collaborations;Cytoprotection;Donor person;Embryo;end stage liver disease;experience;functional improvement;Funding;Generations;Genetic;Hepatic;Hepatic Tissue;Hepatocyte;Homeostasis;Human;Immune;immune activation;Immunobiology;Immunology;immunoregulation;Impairment;improved;improved outcome;Inferior;Infiltration;Inflammation;Inflammatory;innovative technologies;Ischemia;isoimmunity;Journals;Kinetics;Kupffer Cells;Ligands;Liver;liver inflammation;liver ischemia;Liver neoplasms;liver transplantation;Macrophage;Mediating;Molecular;Monitor;monocyte;Morbidity - disease rate;mouse model;Mus;Myeloid Cell Activation;Myeloid Cells;Natural Immunity;neutrophil;Neutrophil Infiltration;notch protein;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Organ;Organ Donor;Organ Transplantation;originality;Outcome;Pathology;Pathway interactions;Patients;Peer Review;personalized medicine;Phenotype;preconditioning;Predisposition;preservation;prevent;Process;Productivity;programs;Progress Reports;Protein Isoforms;Publications;Publishing;Regulation;Rejuvenation;Reperfusion Injury;Reporting;Research Personnel;Resolution;response;restoration;retransplantation;Risk;Role;Scientist;Signal Pathway;Solid;Sterility;Stress;success;Syndrome;synergism;T-Lymphocyte;Therapeutic;Therapeutic Intervention;Tissues;TLR4 gene;TLR7 gene;tool;Translational Research;Transplant Recipients;Transplantation;Transplantation Tolerance

PROJECT_TITLE: Innate-Adaptive Immunoregulation in Liver Transplant Ischemia/Reperfusion Injury


NIH_SPENDING_CATS: Rare Diseases

ORG_CITY: SEATTLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE Endocrine diseases have a substantial impact on public health. Cushing’s syndrome occurs when the body produces too much of the stress hormone cortisol. This is often a consequence of defective cAMP signaling in adrenal glands. We test two transformative ideas that change how we think about Cushing’s syndrome. 1) Losing spatial control of the enzyme protein kinase A (PKA) is a molecular event that drives adrenal Cushing’s syndrome and 2) related disease-causing mutations in PKA promote distinct pathological effects.

PI_NAMEs: SCOTT, JOHN D (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: A kinase anchoring protein;adenoma;Adrenal Cortex;Adrenal Gland Neoplasms;Adrenal Glands;adrenal hyperplasia;Alleles;Amendment;Anabolism;Arginine;Back;Biochemical;Blood Circulation;Blood Glucose;blood pressure elevation;Catalytic Domain;Cell Nucleus;Cells;chemotherapy;Chronic;Clinical;comorbidity;Cushing Syndrome;Cushingoid facies;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Defect;Development;Diabetes Mellitus;Disease;disease-causing mutation;Endocrine;Endocrine System Diseases;Enzyme Stability;Enzymes;Event;Exclusion;Exposure to;Female;Glucose;Holoenzymes;Hormones;Hydrocortisone;Hypertension;intracellular protein transport;Island;Knock-in Mouse;Left;Lesion;men;Molecular;mouse model;Mus;mutant;Mutation;Operative Surgical Procedures;Organ Size;Other Genetics;Outcome;Pathogenesis;Pathogenicity;Pathologic;Pathology;Patients;Pharmaceutical Preparations;Phenotype;Phosphotransferases;Pituitary Neoplasms;Point Mutation;precision medicine;protein distribution;Proteins;Public Health;Radiation;restoration;Rosaniline Dyes;Sampling;Signal Pathway;Signal Transduction;Signaling Protein;Site;spatiotemporal;Stains;Stress;Symptoms;Testing;Tissues;transmission process;Variant;virtual;Weight Gain;Woman

PROJECT_TITLE: Defective PKA Signaling in Cushing's Syndrome

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Digestive Diseases;Liver Disease;Organ Transplantation;Transplantation

PROJECT_TERMS: Accounting;Administrative Coordination;Administrator;Advisory Committees;animal care;Bibliography;Budgets;Clinical assessments;Communication;data sharing;Disputes;Ensure;Expenditure;Funding;Goals;Grant;Human Resources;IACUC;immunoregulation;Individual;Institution;Institutional Review Boards;Ischemia;Joints;Laboratories;liver transplantation;Logistics;Maintenance;Manuscripts;meetings;Monitor;Office of Administrative Management;organizational structure;Participant;Performance;performance site;Preparation;programs;Progress Reports;Protocols documentation;Reperfusion Injury;Research;Research Personnel;Resolution;Resources;Schedule;Shipping;Site Visit;Specialist;success;symposium;synergism;Teleconferences;Time;transplant centers;Travel;United States National Institutes of Health;Work

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Liver Disease;Organ Transplantation;Transplantation

PI_NAMEs: KALDAS, FADY M (contact)

PROJECT_TERMS: Allogenic;Animal Experiments;Animal Model;Archives;Area;Basic Science;bench to bedside;Biological;Biopsy;Blood;Blood specimen;Caring;Clinical;Clinical Data;Clinical Research;Collaborations;Collection;Consent;cost;Cryopreservation;Data;Databases;Development;Equipment;experience;experimental study;Flushing;Functional disorder;Future;Generations;Glean;Goals;Hepatic;Hepatocyte;hepatoprotective;Human;human tissue;Immune;immunoregulation;Impairment;implantation;improved;In Situ;Individual;Inflammation;Injections;innovation;insight;Ischemia;isoimmunity;Life;Liquid substance;Liver;liver biopsy;liver transplantation;Mediating;Microsurgery;Modeling;mouse model;Mus;Myeloid Cells;Operative Surgical Procedures;Organ Transplantation;Outcome;patient responsibilities;Patients;Performance;Perioperative Care;Peripheral;Portal vein structure;post-transplant;Postoperative Care;Postoperative Period;prevent;Procedures;Process;programs;prospective;Regulation;Reperfusion Injury;Reperfusion Therapy;Resolution;Role;sample collection;Sample Size;Sampling;screening;Serum;Signal Pathway;Stress;surgery outcome;T-Lymphocyte;targeted treatment;Technical Expertise;Techniques;Testing;Therapeutic Intervention;time interval;Tissue Sample;Tissues;Transgenic Organisms;transplant model;Transplant Recipients;Transplantation;Transplantation Surgery;Vent;Warm Ischemia

PROJECT_TITLE: Mouse and Human Liver Surgery Core


NIH_SPENDING_CATS: Bioengineering;Data Science;Digestive Diseases;Liver Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Organ Transplantation;Transplantation

PI_NAMEs: GJERTSON, DAVID  (contact)

PROJECT_TERMS: Adopted;Allogenic;Animals;Architecture;Area;Automobile Driving;Biological Assay;Biometry;California;Cells;Clinical;Clinical Research;clinically relevant;cloud based;Complex;complex data;Computer Analysis;Computer Models;cost;Data;Data Analyses;data infrastructure;data management;data modeling;data repository;Data Set;Databases;deep learning;design;Development;digital;dimension reduction;Discriminant Analysis;Disease;Ensure;experimental study;Face;Fire - disasters;Future;Generations;generative adversarial network;Genes;Goals;Health Insurance Portability and Accountability Act;Hepatic;heterogenous data;Histopathology;Human;Image;Immune;Immune response;Immunological Models;Immunophenotyping;immunoregulation;improved;Injury;interest;Ischemia;learning community;liver ischemia;liver transplantation;longitudinal analysis;Los Angeles;Machine Learning;machine learning method;machine vision;Manuscripts;Meditation;Methodology;Methods;Modeling;Molecular;Monitor;mouse model;multimodal data;Mus;Myeloid Cells;network models;neural network;Noise;novel;Outcome;Pathologic;Pathway Analysis;Pathway interactions;Phase;phenotypic data;preclinical study;predictive modeling;Preparation;Procedures;Process;programs;Proteins;Reperfusion Injury;Reporting;repository;Research;Research Personnel;Research Project Grants;Resource Sharing;response;Role;Sampling;Secure;Services;Signal Transduction;Site;System;tool;training data;transcriptome;transcriptome sequencing;transcriptomics;Transplantation;trend;Universities;Visualization;Water

PROJECT_TITLE: Computational Core: Biostatistical Analysis and Network Modelling


NIH_SPENDING_CATS: Pediatric

ORG_CITY: CHICAGO

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: This proposal focuses on dissecting of the molecular mechanisms involved in the control of cell division, cell polarization, and morphogenesis. These simultaneously interrelated and functionally distinct processes are controlled by small GTPases, switch like proteins that primarily act at cell membranes to remodel cellular physiology. We propose to study the role of several small GTPases during these processes in intact model organisms, including the nematode C. elegans and the fruit ﬂy, Drosophila using a combination of live cell imaging, classical genetics, and optogenetics.

PI_NAMEs: GLOTZER, MICHAEL A. (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Caenorhabditis elegans;Cell division;Cell membrane;Cell Physiology;Cells;Congenital Abnormality;Drosophila genus;Family;Genetic;Guanosine Triphosphate Phosphohydrolases;live cell imaging;Malignant Neoplasms;model organism;Molecular;Monomeric GTP-Binding Proteins;Morphogenesis;Nematoda;optogenetics;polarized cell;Process;Proteins;rho;Role;Tissues

PROJECT_TITLE: Spatial and temporal control of Rho family GTPases

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Organ Transplantation;Transplantation

PROJECT_TERMS: Acceleration;Acute;Address;Advocate;Alternative Splicing;Anti-Inflammatory Agents;Autophagocytosis;Biological Markers;Biometry;Biopsy;Brain Death;carcinoembryonic antigen-related cell adhesion molecules;Cardiac Death;Cell Culture System;Cell Death;Cells;Clinical;clinically relevant;Complement component C1;Cryopreservation;Cytoplasm;Cytoprotection;Data;end stage liver disease;Exclusion;Exons;experimental study;functional improvement;Genes;Hepatic;Hepatic Tissue;Hepatocyte;Human;Immune;immunodeficiency;immunoregulation;Impairment;improved;Infiltration;Inflammation;Injury;insight;Intervention;Ischemia;Life;Liver;liver function;liver inflammation;liver ischemia;liver transplantation;Lymphocyte;Macrophage;MAP Kinase Gene;Mediating;Messenger RNA;mortality;mouse model;Mucosal Immunity;Mus;Myelogenous;Natural Immunity;Natural regeneration;neutrophil;novel;novel therapeutics;Operative Surgical Procedures;Organ;Organ Donor;Organ Preservation;Organ Transplantation;Outcome;p38 Mitogen Activated Protein Kinase;Pathway interactions;Patients;Phase;Phenotype;preservation;prevent;programs;Protein Isoforms;Recovery;regenerative;Regulation;Rejuvenation;repaired;Reperfusion Injury;Reporting;Resistance;Resolution;RNA Splicing;screening;Sentinel;Signal Transduction;standard of care;Sterility;Stress;success;synergism;Tissues;Transgenic Mice;transplant model;Transplantation;Transplantation Surgery;Variant;Waiting Lists;Warm Ischemia

PROJECT_TITLE: CEACAM1 Alternative Splicing in Liver Ischemia-Reperfusion Injury


ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Collagens are essential components of the extra-cellular matrix and basement membranes and mutations in these proteins result in severe diseases. Here, we propose an integrated approach that combines chemical biology, computational protein design and biochemistry to elucidate the mechanistic details of how the efficiency of initial trimerization dictates overall collagen biosynthesis. These studies will reveal how disease-associated mutation damage the unique folding pathway of collagens and potentially elucidate therapeutic approaches to treat collagen associate disorders (CADs).

PI_NAMEs: GALE-DAY, ZACHARY  (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Affinity;Anabolism;Basement membrane;Biochemical;Biological Assay;Biology;Biotechnology;bone;C-terminal;Categories;Cell Line;cell motility;Cells;Cerebral small vessel disease;Cerebrovascular system;Chemicals;Clinical;Collagen;Collagen Diseases;Collagen Type IV;Collection;Defect;design;Disease;disease-causing mutation;Environment;experience;experimental study;extracellular;Extracellular Matrix;Extracellular Space;Eye;Foundations;Future;Genetic;Goals;Homo;Impairment;In Vitro;innovation;Kidney;Knowledge;Length;Luciferases;Measures;mechanical properties;Mediating;Mentors;Methods;Missense Mutation;Modeling;mutant;Mutation;N-terminal;Osteogenesis Imperfecta;Pathogenesis;Pathogenicity;Pathway interactions;Phenotype;Point Mutation;Protein Biochemistry;Protein Engineering;protein protein interaction;Proteins;Protomer;Reporting;Research;Role;Signal Transduction;skills;Structure;Testing;Therapeutic;Tissues;tool;training opportunity;translational study;triple helix;white matter;Work

PROJECT_TITLE: Defining the role of NC1 domain assembly in collagen biosynthesis and collagen associated disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PI_NAMEs: GAMMON, DON BRAD (contact)

PROJECT_TERMS: Address;Affect;Arbovirus Infections;Arboviruses;Attention;Bacteria;Bacterial Infections;Bacteriophages;Biological Assay;Biological Models;Cell Physiology;cell type;Cells;Cellular biology;Chiroptera;comparative genomics;CRISPR/Cas technology;Cytoplasm;Data;Eukaryotic Cell;Expression Library;Family;Filovirus;Genes;genome editing;genome-wide;genomic profiling;Glean;Goals;Grant;Human;Immune;Immune Evasion;Immune response;Immune system;Immunity;Immunologic Factors;Immunologics;Immunology;Immunosuppression;Infection;innate immune mechanisms;Innate Immune Response;innovation;Insecta;insight;Integration Host Factors;Libraries;Methodology;Methods;Natural Immunity;novel;pathogen;Pathogenesis;pathogenic bacteria;pathogenic virus;Pathway interactions;Population;Predisposition;protein degradation;protein function;Protein Secretion;Proteins;Proteomics;Public Health;Research;respiratory virus;Rhabdoviridae;Ring Finger Domain;RNA Interference;RNA interference screen;screening;Shigella flexneri;System;Techniques;Testing;Therapeutic;Togaviridae;tool;transcriptomic profiling;transmission process;ubiquitin ligase;Vaccines;Viral reservoir;Virulence Factors;Virus;Virus Diseases;Virus Replication;Work;yeast two hybrid system;Yeasts

PROJECT_TITLE: Using Bacterial Effectors to Uncover Innate Immune Mechanisms Restricting Viral Replication in Bat Cells


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Organ Transplantation;Transplantation

PI_NAMEs: ZHAI, YUAN  (contact)

PROJECT_TERMS: Address;Adult;Affect;Anti-Inflammatory Agents;Arachidonate 5-Lipoxygenase;Bone Marrow;Ca(2+)-Calmodulin Dependent Protein Kinase;calmodulin-dependent protein kinase II;cell type;clinical application;Cre lox recombination system;Cryopreservation;Data;Development;Dichloromethylene Diphosphonate;Disease;Down-Regulation;Embryo;Enzymes;Excision;Experimental Designs;experimental study;Fibrosis;Future;Gene Expression;Genes;Graft Rejection;Hepatocellular Damage;Hepatocyte;Histologic;Histopathology;Homeostasis;Human;immune activation;immunoregulation;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Ischemia;isoimmunity;ITGAM gene;Kinetics;Kupffer Cells;Lead;Liposomes;Lipoxygenase;Liver;liver function;liver inflammation;liver ischemia;Liver neoplasms;liver transplantation;Liver X Receptor;Macrophage;Measures;Mediating;Mediator;Modeling;Molecular;monocyte;mouse genetics;Mus;Myelogenous;Myeloid Cell Activation;neutrophil;Neutrophil Infiltration;novel;Outcome;Pathogenesis;Pathway interactions;Pattern;Pattern recognition receptor;pharmacologic;Play;Process;programs;Property;Quantitative Reverse Transcriptase PCR;Receptor Protein-Tyrosine Kinases;reconstitution;Recovery;repaired;Reperfusion Injury;Resolution;restoration;Risk Factors;Role;Source;Specificity;Stress;success;Testing;therapeutic target;tissue injury;Tissues;tool;transplant model;Transplantation;Up-Regulation;validation studies;Warm Ischemia

PROJECT_TITLE: Inflammation Resolution in Liver Ischemia-Reperfusion Injury


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: UNION

ORG_NAME: KATHERA BIOSCIENCE INC.

PHR: Project Narrative In January 2020, the NIH Institutes of Allergy and Infectious Diseases gathered leading investigators and clinicians from around the world to discuss the emergence of a multi-drug resistant pathogen called Candida auris and the global problem of systemic fungal infections. The conference highlighted the critical need to develop new, broad-spectrum antifungal drugs to combat not only Candida auris but other Candida and Aspergillus species because of increasing resistance to azole drugs, and growing echinocandin resistance in C. glabrata. This proposal aims to develop a unique and systematic Redesigning Existing Drugs against Indispensable Targets (ReEDIT) platform technology to identify essential fungal genes whose products are inhibited by Chemically Tractable Inhibitors (CTIs), originally developed against human orthologs, and advance essential targets and drug candidates into lead optimization programs, accelerating development of novel drugs to treat life threatening fungal infections.

PI_NAMEs: PARENT, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Acceleration;Address;analog;anti-fungal agents;Aspergillus;Azole resistance;Binding Sites;Biochemical;Bioinformatics;Biological;Biological Assay;Candida;Candida albicans;Candida auris;Candida glabrata;candidate identification;Cell Wall;Cells;chemical genetics;Chemicals;cheminformatics;Clinical;clinical development;clinical diagnosis;Clinical Trials;clinically relevant;combat;Communicable Diseases;cytotoxicity;Data;Dependence;design;Development;Diploidy;drug candidate;drug development;Drug Interactions;Drug resistance;Drug Targeting;drug testing;druggable target;echinocandin resistance;emerging pathogen;Engineering;Essential Genes;Exhibits;Fungal Genes;Fungal Proteins;Gene Targeting;Genes;Genetic;Goals;Growth;high throughput screening;Human;Hypersensitivity;improved;in vivo Model;Informatics;inhibitor;Lead;lead optimization;Life;Measures;Membrane;molecular modeling;multi-drug resistant pathogen;Mycoses;new therapeutic target;novel;novel therapeutics;Orthologous Gene;Outcome;pathogenic fungus;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phase;preclinical development;preclinical study;Predisposition;Probability;programs;Property;Reporter;Repression;Research Personnel;Resources;Series;Small Business Innovation Research Grant;small molecule inhibitor;Specificity;Study models;symposium;technology platform;Testing;tool;Toxic effect;Toxicology;United States National Institutes of Health

PROJECT_TITLE: A Redesigning Existing Drugs against Indispensable Targets (ReEDIT) platform technology for discovery of novel drugs to treat fungal infections


ADMINISTERING_IC: HD

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Social Determinants of Health

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Child poverty in combination with the enduring and inequitable burden of the COVID-19 pandemic underscores the urgent importance of understanding the effects of poverty on diverse children and families. Although many children flourish despite the stress that economic hardship brings, chronic and unpredictable poverty-related adversities put children at an increased risk of developing cognitive, emotional, and behavioral difficulties that, while potentially adaptive in the immediate context of poverty, may disrupt their capacity to meet the learning and psychosocial demands of formal schooling. Using data from a mixed-methods national survey of predominantly low-income families during the pandemic, the current project addresses central questions concerning (1) what, when, for whom, and how poverty-related experiences unfold during pivotal developmental periods; and (2) how such experiential manifestations enhance or impair core regulatory skills critical for children’s successful adaptation across contexts.

PI_NAMEs: DEJOSEPH, MERIAH L (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Address;Affect;Attention;Behavioral;Buffers;career;Caregivers;Child;child poverty;Chronic;Cognitive;Communities;community violence;comparison group;Complex;COVID-19 burden;COVID-19 pandemic;Data;deprivation;Development;Dimensions;Disparity;early childhood;early life adversity;economic disparity;Economics;emotion regulation;Emotional;Environment;experience;Exposure to;Family;Fellowship;Grain;Home;Impairment;Income;Inequity;infancy;Informal Social Control;innovation;insight;Intervention;Learning;Life;Life Experience;life span;Link;lower income families;Measures;Methodology;Methods;Modeling;novel;Outcome;pandemic disease;Pathway interactions;Pattern;Personal Satisfaction;Play;Policies;Poverty;Process;programs;Psychometrics;psychosocial;Public Health;Quasi-experiment;Race;Recording of previous events;Research;Research Personnel;response;Risk;Role;Sampling;Schools;Science;Series;Shapes;skills;sociodemographic group;Stress;success;Surveys;System;Testing;Theoretical model;Time;tool;Training;United States;Work;Youth

PROJECT_TITLE: Disentangling the role of poverty-related experiences on children's self-regulation: Identifying dynamic and contextually-relevant mechanisms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


PI_NAMEs: REED, ELAINE F (contact)

PROJECT_TERMS: Acute;adaptive immune response;Adaptive Immune System;adaptive immunity;Allografting;antagonist;Antibodies;arm;Automobile Driving;Biological Markers;Biopsy;Blood;cell free DNA;cell injury;Cells;Chronic;Clinical;cofactor;Complex;cytokine;Cytoplasmic Vesicles;Data;Diagnostic;Disulfides;donor-specific antibody;end stage liver disease;extracellular;Flushing;Generations;HDAC5 gene;hepatoprotective;HMGB1 gene;Human;Immune;Immune system;Immunophenotyping;immunoregulation;improved;In Situ;In Vitro;in vivo;Inflammation;Inflammatory;Injury;Innate Immune System;Ischemia;ischemic injury;isoimmunity;Ligands;Liver;liver injury;liver transplantation;Macrophage;Mediating;Metadata;Mitochondrial DNA;Molecular;mouse model;Myelogenous;Myeloid Cell Activation;Myeloid Cells;Natural Immunity;neutrophil;novel;Organ;Organ Preservation;Organ Transplantation;Outcome;Pathway interactions;Patients;Pattern;Pattern recognition receptor;Peptidoglycan;Peripheral;peripheral blood;Phenotype;Play;post-transplant;preconditioning;Predisposition;prevent;Process;Production;Publishing;Receptor Inhibition;Reperfusion Injury;Reperfusion Therapy;Research;Resolution;response;retransplantation;Rodent Model;Role;Seminal;Severities;Signal Pathway;Signal Transduction;Site;Sterility;synergism;T-Lymphocyte;Therapeutic;Therapeutic Intervention;therapeutic target;Tissues;TLR4 gene;TLR7 gene;Transplant Recipients;Transplantation


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Stable integration of the HIV-1 viral genome to the host genome is the reason this infection cannot be cured. Features of host chromatin that enable HIV-1 integration and the components that engender these elements have not been thoroughly elucidated. We propose to investigate the functional and regulatory roles of host chromatin marks and modifiers during integration to reveal novel targets for antiretroviral therapeutics.

PI_NAMEs: LARUE, ROSS C. (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affinity Chromatography;Anti-Retroviral Agents;antiretroviral therapy;Binding;Binding Proteins;Bioinformatics;C-terminal;cell type;Cells;cellular engineering;ChIP-seq;Chromatin;cofactor;Complex;Data;Databases;Disease;Elements;Encyclopedia of DNA Elements;Ensure;Event;Fluorescence;Fluorescence Microscopy;Fluorescence Resonance Energy Transfer;Gene Expression;Genes;Genetic Transcription;Genome;Genomics;Goals;Histone H3;histone methylation;histone modification;Histones;HIV;In Vitro;in vivo;Individual;Infection;Integrase;integration site;Intercistronic Region;Kinetics;Location;Lysine;Magnetism;Maps;Mass Spectrum Analysis;Mediating;Methylation;Modality;N-terminal;novel;Nucleosomes;Patients;Persons;Post-Translational Protein Processing;preference;Process;Production;Proteins;Provirus Integration;Proviruses;PWWP Domain;Recombinants;Role;single molecule;Site;Technology;Therapeutic;therapeutic target;Time;Transcription Coactivator;Transcription Initiation Site;transcriptional coactivator p75;Viral;viral DNA;Viral Genome;Virus;Virus Diseases;Virus Integration

PROJECT_TITLE: HISTONE MODIFICATIONS GUIDING HIV INTEGRATION

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Fragile X Syndrome;Genetics;Infectious Diseases;Influenza;Intellectual and Developmental Disabilities (IDD);Pediatric;Pneumonia and Influenza;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative We will investigate the mechanism of translational control by FMRP and its paralogs, FXR1 and FXR2, which may help in finding a treatment for fragile X syndrome. Additionally, we will investigate the mechanism of translation initiation on influenza A virus mRNAs, which could provide insights for developing drugs to treat influenza infections.

PI_NAMEs: JOSEPH, SIMPSON  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: American;Anti-viral Agents;autistic behaviour;autosome;Binding;Biochemical;biophysical techniques;Brain;Cells;Cellular Stress;Cessation of life;Childhood;Code;Complex;Conserved Sequence;Data;Development;Disease;Drug Targeting;Eukaryotic Initiation Factor-4E;FMR1 gene;Fragile X Syndrome;FXR1 gene;FXR2 gene;Gene Silencing;Genes;Goals;In Vitro;Influenza A virus;influenza infection;insight;Intellectual functioning disability;Knowledge;Mammals;Messenger RNA;Molecular;mRNA Expression;paralogous gene;Patients;Persons;Pharmaceutical Preparations;Poly(A)-Binding Proteins;programs;Protein Biosynthesis;Proteins;Public Health;recruit;Regulation;Research;Resistance;RNA-Binding Proteins;Seizures;System;Techniques;Translation Initiation;Translation Process;Translations;Untranslated Regions;Viral;Virus Diseases

PROJECT_TITLE: Mechanism of Protein Synthesis and Translational Control

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: CORVALLIS

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: Public Health Relevance We hope to be able to solve atomic structures of biologically related materials including proteins. The information will be instrumental for understanding mechanisms of diseases and for designing efficient therapeutic drugs.

PI_NAMEs: KONG, WEI  (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Address;Biological;Cations;Cells;Charge;Collection;Computer software;computerized data processing;cryogenics;Data;Data Analyses;density;design;detector;digital;dimer;dipole moment;Disease;drug discovery;Drug Screening;electric field;Electron Beam;electron diffraction;Electrons;Electrospray Ionization;Electrostatics;Elements;Explosion;Foundations;Freezing;Goals;Guns;Helium;Heterogeneity;high risk;Individual;innovation;instrument;ion source;Ions;Label;Lasers;Ligands;macromolecule;mass spectrometer;Mass Spectrum Analysis;member;Membrane Proteins;Methods;Microfluidics;Molecular;Molecular Conformation;Mutation;nanocrystal;nanoelectrospray;nanoionics;nanomaterials;Noise;particle;Pattern;Pharmaceutical Preparations;Phase;Physiologic pulse;Process;Property;protein complex;protein protein interaction;Proteins;public health relevance;Pyrenes;recruit;Resolution;Retrieval;risk mitigation;Sampling;Shapes;Signal Transduction;small molecule;Source;Specialist;structural biology;Structure;Technology;Temperature;Therapeutic;Time

PROJECT_TITLE: Combining native protein mass spectrometry with serial electron diffraction to solve atomic structures of mass selected macromolecules

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Diabetes;Digestive Diseases;Genetics;Human Genome;Liver Disease;Nutrition

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Hepatic insulin resistance is a key factor in the progression of type 2 diabetes, as well as an unmet treatment need. Studies supported by this grant have provided insight into mechanisms of hepatic insulin action and resistance, and suggested alternative approaches to its treatment. Key advances in the last cycle–including the discovery of a new mechanism to account for the twin pathogenic abnormalities of increased hepatic glucose production and dyslipidemia in diabetes, the development of FoxO1-based selective insulin sensitizers, and the discovery of Gpr17 as a mediator of insulin and leptin signaling to promote energy efficiency–offer hope that the disease can be reversed and prompt a strategic reassessment of drug discovery.

PI_NAMEs: ACCILI, DOMENICO  (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Address;Affect;Affinity Chromatography;Binding;Binding Sites;Biological;Candidate Disease Gene;Catecholamines;Cells;Chimeric Proteins;ChIP-seq;Chromatin;chromatin immunoprecipitation;chromosome conformation capture;comparative;Complex;CREB1 gene;Data;Dependence;design;Development;Diabetes Mellitus;Disease;DNA;DNA Binding;drug discovery;Dyslipidemias;energy balance;energy efficiency;Enhancers;Equilibrium;experimental study;Factor Analysis;Family;Fasting;feeding;forkhead protein;FOXO1A gene;Functional disorder;Funding;G-Protein-Coupled Receptors;Gene Expression;Gene Expression Regulation;Genes;genetic corepressor;Genetic Transcription;genome-wide;Glucagon;Glucocorticoid Receptor;Glucokinase;Glucose;glucose metabolism;glucose production;Grant;Hepatic;hormonal signals;Hormones;inhibitor;insight;Insulin;insulin mediators;Insulin Resistance;insulin sensitizing drugs;insulin signaling;Integration Host Factors;interest;Introns;Investigation;Knock-in;Knowledge;Leptin;Link;lipid metabolism;Lipid Mobilization;Lipids;Lipoproteins;Liver;Mass Spectrum Analysis;Messenger RNA;Metabolic;Metabolic Diseases;Metabolism;Methods;Monitor;mouse model;Mus;Neuropeptides;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutic intervention;Nuclear Receptors;nucleocytoplasmic transport;Nutrient;Organism;Paper;Pathogenesis;Pathogenicity;Pathway interactions;Peroxisome Proliferator-Activated Receptors;Proteins;Publishing;Reagent;Regulation;Reporter;Reproducibility;Research;Research Personnel;Resistance;response;Role;Signal Transduction;Site;Techniques;Time;transcription factor;Transcriptional Regulation;transcriptome sequencing;Twin Multiple Birth;Venus;Work;Yawning

PROJECT_TITLE: Role of Forkhead proteins in insulin action

STUDY_SECTION: CADO

STUDY_SECTION_NAME: Cellular Aspects of Diabetes and Obesity Study Section[CADO]


ORG_DEPT: PHYSIOLOGY

PHR: PROJECT NARRATIVE During normal physiologic stress (such as endurance exercise training), the heart muscle increases in size (undergoes hypertrophy), but in disease the heart muscle undergoes hypertrophy but later becomes weak (heart failure). We propose to study a process called Store-Operated Calcium Entry (SOCE) in both favorable (physiologic stress due to exercise) and unfavorable forms (resulting in heart failure) of altered heart structure and function. Findings from these studies may be used to find new therapies for heart failure.

PI_NAMEs: GYORKE, SANDOR  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Animal Experiments;Biology;Calcium;Calcium Signaling;Cardiac;cardiac muscle disease;Cardiac Myocytes;Catecholamines;Cell Physiology;Cells;Complex;Cytosol;Dedications;Development;Disease;effective therapy;Endoplasmic Reticulum;endurance exercise;Event;Exercise;exercise training;extracellular;Foundations;Functional disorder;gain of function;Genetic;Genetic Transcription;Growth;Healthcare;Heart;Heart Abnormalities;Heart Diseases;Heart failure;Heart Hypertrophy;Human;Hypertrophy;imaging approach;Imaging Techniques;insight;Intercalated disc;Mediating;Messenger RNA;Methods;Modeling;Molecular;mouse model;Mouse Strains;Mus;Muscle Cells;Myocardial;Myocardium;nano;Nanoscopy;novel;novel therapeutics;Pathologic;Pathology;Physical Exercise;Physiological;Physiology;Play;Preparation;Process;Protein Biosynthesis;Proteins;Reporter;Reporting;response;RNA Splicing;Role;Sarcomeres;Sarcoplasmic Reticulum;Secondary to;single molecule;Site;Stress;Stress cardiomyopathy;Structure;superresolution microscopy;System;Techniques;Technology;Testing;Time;tool;Translating;Translations;treadmill;Up-Regulation;Variant;Ventricular

PROJECT_TITLE: Abnormal intracellular calcium release in heart failure

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Genetics;Hematology;Pediatric;Primary Immunodeficiencies;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Defects in the length of the specialized structures at the ends of human chromosomes, known as telomeres, can lead to myriad medical problems including a failure of the bone marrow to produce blood cells. Persons born with certain mutations in the gene TINF2 have very short telomeres and develop bone marrow failure at a very young age. This project seeks to understand why these particular mutations have such catastrophic effects on telomere length and utilizes a novel humanized mouse model to examine the impact of TINF2 mutations on telomere length and bone marrow function, and test potential therapeutic approach to treat the associated-bone marrow failure.

PI_NAMEs: BERTUCH, ALISON A (contact);HOCKEMEYER, DIRK

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Affect;Age;Androgens;Attenuated;Binding;Biological Models;Biology;Blood Cells;Body System;Bone Marrow;Bone Marrow Cell Transplantation;Bone marrow failure;Cause of Death;Cell Culture Techniques;Cell Differentiation process;Cells;Child;Childhood;Chromatin;Chromosomes;Clinical;Collaborations;Complex;Danazol;Data;Defect;Disease;disease model;Dyskeratosis Congenita;early childhood;early onset;Elements;Enzymes;Epitopes;Event;fitness;Funding;gain of function;Gene Expression Profile;Genes;Genetic;genetic approach;Germ Lines;Goals;Hematopoiesis;Hematopoietic;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Human Chromosomes;humanized mouse;Impairment;improved;In Vitro;in vivo;in vivo Model;Individual;insight;Intervention;Knowledge;Lead;Length;Life;Link;Maintenance;Mediating;Medical;Missense Mutation;Molecular;Molecular Genetics;Molecular Profiling;Morbidity - disease rate;mouse model;mutant;Mutation;Nature;novel;Outcome;Pathogenicity;Pathway interactions;Patients;Persons;pharmacologic;Phenotype;Pluripotent Stem Cells;Positioning Attribute;pre-clinical;Pre-Clinical Model;protein complex;Protein Isoforms;Proteins;response;Role;stem cell model;stem cells;Structure;System;Telomerase;telomere;Telomere Length Maintenance;Telomere Shortening;Telomeric Repeat Binding Protein 1;TERF1 gene;Testing;Therapeutic;therapeutic development;therapeutic evaluation;therapeutic target;TINF2 gene;Toxic effect;Variant

PROJECT_TITLE: Molecular Genetics of the Telomere Biology Disorders

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Infectious Diseases;Patient Safety;Pediatric;Sepsis

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Stress Hydrocortisone In Pediatric Septic Shock (SHIPSS) Narrative Sepsis represents the most common cause of childhood mortality worldwide, with 200 cases of pediatric sepsis diagnosed each day in the U.S. alone, with an associated hospital mortality rate of 5-10%, and health care expenditures approaching $5 billion annually. This prospective, randomized, double-blinded, placebo-controlled interventional trial will examine the potential benefits and risks of adjunctive hydrocortisone prescribed to critically ill children with fluid and vasoactive-inotropic refractory septic shock. It will benefit public health by providing the heretofore missing evidence to inform guidelines regarding therapy for septic shock in children.

PI_NAMEs: AGUS, MICHAEL SD (contact);WYPIJ, DAVID ;ZIMMERMAN, JERRY JOHN

PROGRAM_OFFICER_NAME: JENKINS, TAMMARA L

PROJECT_TERMS: Acute;adaptive immunity;Address;Admission activity;Adrenal Cortex Hormones;Adrenal gland hypofunction;Adult;Adverse event;Algorithms;Antibiotics;Benefits and Risks;Biological Markers;biomarker performance;biomarker validation;Cessation of life;Child;Childhood;Clinical;clinical practice;Critically ill children;Data;Death Rate;Delirium;Diagnosis;Disease;Double-Blind Method;double-blind placebo controlled trial;Electroconvulsive Therapy;Enrollment;Equipment and supply inventories;Event;Exhibits;Extracorporeal Membrane Oxygenation;Failure;Family dynamics;Functional disorder;functional status;Funding;Gastrointestinal Hemorrhage;Gene Expression Profile;Genetic Transcription;Glucocorticoids;Guidelines;Health Care Costs;Health Expenditures;health related quality of life;hemodynamics;Hospital Mortality;Hospitalization;Hospitals;Human Genome;Hydrocortisone;Hyperglycemia;Immune response;Impairment;improved;Infusion procedures;innovation;Institution;Intervention;Intervention Trial;Knowledge;Liquid substance;Meta-Analysis;Modeling;mortality;mortality risk;Multiple Organ Failure;Neonatal;Nosocomial Infections;Organ;Outcome;Outcome Measure;Parents;Pathogenesis;patient oriented;Patients;Pediatric Intensive Care Units;pediatric sepsis;Pharmaceutical Preparations;Pituitary-Adrenal System;Placebo Control;Placebos;prevent;primary outcome;prognostic;prospective;Public Health;Quality of life;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;Refractory;Renal Replacement Therapy;Reporting;Research;Resources;Resuscitation;Risk;secondary outcome;Sepsis;Septic Shock;Severity of illness;Specific qualifier value;Stress;Subgroup;Testing;Therapeutic Intervention;Time;treatment guidelines;Treatment Side Effects;United States;ventilation

PROJECT_TITLE: SHIPSS:  Stress Hydrocortisone In Pediatric Septic Shock


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Mental Health;Pediatric;Rare Diseases

PHR: Project Narrative The SET1/MLL methyltransferases constitute a novel family of intracellular enzymes, which are responsible for regulating gene expression in all eukaryotic cells by catalyzing histone methylation. Dysregulation of members of this enzyme family is closely associated with neurological disorders including schizophrenia, autism, and intellectual disability, as well as other human diseases such as cancers and congenital heart disease. This proposal is aimed at revealing the molecular mechanisms underlying the functions and regulation of a prototypical yeast SET1/MLL methyltransferase complex, which will benefit our understanding of the basic biology of transcription regulation and the etiology of diseases associated with the mutation and dysregulation of the human SET1/MLL orthologs and paralogs.

PI_NAMEs: CHATTERJEE, CHAMPAK ;ZHENG, NING  (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: Active Sites;Address;Animals;ASH2L gene;autism spectrum disorder;Binding;Biochemical;Biological;Biological Assay;Biological Models;Biology;Cells;Chemicals;Chromatin Structure;clinically relevant;Complex;congenital heart abnormality;Congenital Heart Defects;Cryoelectron Microscopy;Data;Defect;Disease;Elements;Enhancers;Enzyme Kinetics;enzyme substrate;Enzymes;Epigenetic Process;epigenetic regulation;Etiology;Eukaryota;Eukaryotic Cell;Family;Family member;Gene Expression;Gene Expression Regulation;Genetic;Genetic Transcription;Health;Histone H3;histone methylation;Histone-Lysine N-Methyltransferase;Histones;HRX protein;Human;human disease;In Vitro;in vivo;Intellectual functioning disability;interest;leukemia;Light;Link;Lysine;Malignant Neoplasms;Mammals;Maps;Measures;member;Mental disorders;Methods;methyl group;Methylation;Methyltransferase;Mixed-Lineage Leukemia;MLL gene;MLL2 gene;Molecular;Monoubiquitination;Motion;Mutation;Names;Nervous System Disorder;neuropsychiatric disorder;novel;Nucleosomes;Orthologous Gene;Outcome;paralogous gene;Post-Translational Protein Processing;protein complex;Protein Subunits;prototype;Recombinants;reconstitution;Regulation;Reporting;Residual state;response;Role;Saccharomyces cerevisiae;Schizophrenia;Side;Signal Transduction;Specificity;Structure;Structure-Activity Relationship;Testing;Transcriptional Activation;Transcriptional Regulation;Work;Yeast Model System;Yeasts

PROJECT_TITLE: Structure and Mechanism of the SET1/COMPASS H3K4 Methyltransferase Complex

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: The drug supply chain is global and susceptible to disruptive unanticipated events, such as the 2019 Corona- virus (COVID-19) pandemic, but the impact of drug shortages during a global public health emergency and effectiveness of strategies to alleviate drug shortages is unknown. The proposed research is relevant to public health because policy-makers need real world evidence to plan for future global emergencies, drug shortages at large, and inform national- and international-policy to decrease the impact of drug shortages on patient outcomes. Thus, this project is relevant to the AHRQ research priority areas of patient safety, im- provements in health care practice, providing timely response to critical questions, and AHRQ priority groups.

PI_NAMEs: SUDA, KJ  (contact)

PROGRAM_OFFICER_NAME: WAGNER, MEGHAN

PROJECT_TITLE: Impact of COVID-19 on Drug Shortages

STUDY_SECTION: HSVR

STUDY_SECTION_NAME: Healthcare Systems and Values Research[HSVR]