NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Despite established guidelines supporting appropriate cancer screening in order to prevent death and adverse cancer-related outcomes, screening is often underutilized. In this project, we will pilot nudge interventions among older adults – including racial/ethnic minorities, low SES individuals, and other high-risk groups identified using novel analytic methods – and tailor nudges to overcome screening barriers facing these patient groups. We will then conduct a pragmatic, multisite trial evaluating the ability for tailored nudges to clinicians and patients to improve vaccination rates and reduce disparities in care.

PI_NAMEs: LIAO, JOSHUA M;MEHTA, SHIVAN JATIN;NAVATHE, AMOL S (contact);PRONOVOST, PETER J.

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Address;Adopted;Adult;analytical method;arm;Behavior;behavior change;Behavioral;behavioral economics;Benefits and Risks;Breast Cancer Detection;California;cancer health disparity;Cessation of life;Characteristics;clinical care;Collaborations;Colorectal Cancer;colorectal cancer screening;cost;Counseling;Data;Data Science;Decision Making;design;discounting;disparity reduction;Drug Prescriptions;effective intervention;Effectiveness;effectiveness testing;Electronic Health Record;Eligibility Determination;end of life;ethnic minority;Evaluation;experience;feasibility testing;Feedback;Future;Geography;Guidelines;Health;Health behavior;health care disparity;health care settings;Health system;Healthcare;Heterogeneity;heuristics;high risk;high risk population;improved;Individual;Information Technology;Intervention;intervention cost;Leadership;low socioeconomic status;lung cancer screening;Machine Learning;Malignant neoplasm of lung;Malignant Neoplasms;Medicine;mortality;multi-site trial;novel;Ohio;older adult;operation;Outcome;patient subsets;Patient-Focused Outcomes;Patients;Pennsylvania;Performance;Phase;pilot test;pragmatic trial;prevent;preventable death;primary care clinic;Psyche structure;racial minority;Randomized;Randomized, Controlled Trials;Recommendation;scale up;screening;screening disparities;Screening for cancer;Site;social;statistics;Subgroup;Testing;therapy design;Time;treatment response;United States;Universities;University Hospitals;Vaccination;Woman;Work

PROJECT_TITLE: I-SCREEN: Increasing Screening for Cancer using a Randomized Evaluation of EHR-based Nudges


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Vaccines represent a highly effective public health measure to protect individuals from infectious diseases by eliciting the host immune response against microbial antigens. Here, we hypothesize that mannans formulated with alumOH induce a potent and durable adaptive immune response to SARS-CoV-2 Spike by inducing specific innate immune pathways and activation programs. By combining detailed immunogenicity and mechanistic analyses, our proposal will define a novel adjuvant formulation for SARS-CoV- 2 Spike and potentially other viral glycoproteins as well as shed new light on the biology of Dectin-2.

PI_NAMEs: ZANONI, IVAN  (contact)

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: 2019-nCoV;adaptive immune response;adaptive immunity;Adjuvant;Adjuvanticity;Aluminum;Aluminum Hydroxide;Antibodies;Antibody Formation;Antigens;Automobile Driving;Benchmarking;beta-Glucans;Biology;Bone Marrow;C Type Lectin Receptors;Cell Wall;Cells;Chimera organism;Communicable Diseases;cytokine;dectin 1;Development;DNA;Drug Kinetics;Epitopes;Experimental Models;FDA approved;Formulation;Glycoproteins;Goals;Human;Immune;immune activation;Immune response;Immunity;Immunization;Immunize;immunogenicity;Immunoglobulins;improved;In Vitro;in vitro Model;in vivo;Inbreeding;Individual;Injections;innate immune pathways;Innate Immune System;innovation;Interferon Type I;Interferon Type II;Knockout Mice;Lectin Receptors;Ligands;lymph nodes;Lymphocyte;Mannans;Measures;Mediating;microorganism antigen;Modality;Modeling;Molecular;Molecular Mechanisms of Action;mouse dectin-2;mouse model;Mouse Strains;Mus;Mycoses;Myeloid Cells;neutralizing antibody;novel;pathogen;Pathway interactions;Pattern recognition receptor;Phagocytes;physical property;Play;Polysaccharides;Process;programs;Proteins;Public Health;receptor;Respiratory Disease;Risk;Salts;SARS-CoV-2 spike protein;sensor;Site;Specificity;Surface;Testing;Th1 Cells;TLR4 gene;Toll-like receptors;tool;Vaccine Adjuvant;Vaccine Antigen;Vaccines;Viral;Work

PROJECT_TITLE: Development of a novel adjuvant strategy enabled by modulation of the physical properties of fungal mannans

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Radiation Oncology

ORG_CITY: PHILADELPHIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_STATE: PA

PHR: Public Health Relevance Statement: Cherenkov imaging of radiation therapy delivery allows a real-time visual mapping of the skin dose on the patient. Development to quantify this signal and extract signal that directly report on skin dose in a clinical trial will be performed to determine its value in treatment verification, with a focus on cancer patients undergoing total skin electron therapy.

PI_NAMEs: ZHU, TIMOTHY C. (contact)

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: 3-Dimensional;absorption;Agreement;Algorithms;Anatomic Surface;Anatomy;animation;body position;Cancer Patient;cherenkov imaging;Clinical;Clinical Trials;Collaborations;Computer software;Computers;Data;Dependence;detector;Development;Dose;Dose Rate;dosimetry;Electrons;Elements;Engineering;Ensure;Foundations;Geometry;Goals;Human;Hybrids;Image;Imaging technology;improved;in vivo;Incidence;individual patient;invention;Light;light scattering;Linear Accelerator Radiotherapy Systems;Location;Maps;Measurement;Measures;Methods;Monitor;Monte Carlo Method;Movement;Mycosis Fungoides;optical spectra;Optics;Overdose;Patients;Photons;Physiologic pulse;Pilot Projects;Positioning Attribute;Posture;Procedures;Property;prospective;public health relevance;Radiation;radiation delivery;Radiation Dose Unit;Radiation Monitoring;Radiation therapy;Reporting;Scanning;Schools;Signal Transduction;simulation;Site;Skin;Skin Tissue;software systems;Software Tools;Solid;support tools;Surface;System;Techniques;Technology;technology platform;Testing;Time;Tissues;tool;treatment planning;two-dimensional;Umbilicus;Uncertainty;visual map

PROJECT_TITLE: Cherenkov imaging incorporating 3D surface imaging for TSET

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE Relevance to public health Anti-OSP and other antibody responses have been associated with protection against shigella infection. A number of shigella vaccines are being developed; however, we have limited knowledge of the functional attributes of anti-shigella antibodies and their correlation with protection, especially among young children in resource-limited settings. We propose to address these issues in this project.

PI_NAMEs: RYAN, EDWARD T. (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Acute;Address;Adult;American;Antibodies;Antibody Affinity;Antibody Response;Antibody titer measurement;Antigens;Area;arm;Attenuated;bactericide;Bangladesh;Binding;Biological Assay;Biophysics;Cessation of life;Child;Complement;Complement Activation;Conjugate Vaccines;Data;diarrheal disease;Enzyme-Linked Immunosorbent Assay;Evaluation;Fc Receptor;Future;General Hospitals;Genetic Complementation Test;glycosylation;Goals;Household;Human;Immune response;Immune system;Immunity;Immunoglobulin Constant Region;Immunologics;Infection;Innate Immune System;international center;Invaded;Knowledge;Massachusetts;Mediating;Modeling;monocyte;Morbidity - disease rate;mortality;Mucins;neutrophil;NK Cell Activation;O Antigens;Organism;pathogen;Pattern;Phagocytes;Phagocytosis;Plasmids;Play;Process;Public Health;Research;Research Design;Research Institute;Research Personnel;Resource-limited setting;Resources;response;Role;Sampling;Sampling Studies;Shigella;Shigella Infections;Shigella sonnei;Shigella Vaccines;Specificity;System;Universities;Vaccinated;Vaccination;vaccine candidate;vaccine development;vaccine evaluation;vaccine trial;Vaccines;Validation;Virulence Factors;volunteer;Work

PROJECT_TITLE: Functional profiling of OSP-specific and other antibodies during shigella infection


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunization;Immunotherapy;Infectious Diseases;Lung;Microbiome;Prevention;Vaccine Related

ORG_CITY: STANFORD

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Certain bacterial strains from the microbiome induce a highly potent immune response pre-emptively (i.e., before an infection happens). In preliminary work, we have found that by gently swabbing a mouse with a skin bacterium engineered to decorate its surface with a molecule from a tumor, we can trick the immune system into destroying the tumor—as though it were bacterially infected—without harming the healthy tissue around it. Here, we propose to build on this observation to make ‘commensal vaccines’ for a broad range of therapeutic uses including cancer, infectious disease, and autoimmune disease.

PI_NAMEs: FISCHBACH, MICHAEL ANDREW (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Acute Lymphocytic Leukemia;adaptive immune response;Adaptive Immune System;adaptive immunity;Address;Adjuvant;anti-PD-1;antigen-specific T cells;Antigens;antiviral immunity;Area;Autoimmune;Autoimmune Diseases;autoimmune pathogenesis;Autoimmunity;B-Lymphocytes;Bacteria;Basic Science;Biological Products;Biomedical Research;cancer cell;cancer therapy;Cancer Vaccines;CD19 gene;CD8-Positive T-Lymphocytes;Cell Physiology;cell type;Cells;Characteristics;chimeric antigen receptor T cells;Cold Chains;commensal bacteria;Communicable Diseases;cost;COVID-19 vaccine;Data;Discipline;Disease;Disease remission;Ear;Endowment;engineered T cells;Engineering;Epithelium;Failure;Foundations;Goals;Gossypium;Head;Human;Human Microbiome;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;immune function;Immune response;Immune system;Immunity;Immunologic Adjuvants;Immunologics;Immunology;immunoregulation;Immunosuppression;Infection;inhibitor;innovation;insight;Intravenous;low and middle-income countries;Malignant Neoplasms;Melanoma;Metastatic Neoplasm to the Lung;Methods;microbiome;Modality;Modeling;Mucosal Immune Responses;Mucosal Immunity;Mus;Nature;Needles;neoplastic cell;non-Native;nonhuman primate;Oncology;Opportunistic Infections;Organism;pandemic pathogen;patient subsets;Patients;prevent;Process;programs;Property;Regulatory T-Lymphocyte;Respiratory Disease;response;RNA vaccine;Sampling;scaffold;Side;side effect;Skin;Solid Neoplasm;Specificity;standard of care;Staphylococcus epidermidis;subcutaneous;success;Surface;Swab;T-Lymphocyte;Therapeutic;Therapeutic Uses;Tissues;TNF gene;tool;Topical application;Toxic effect;tumor;Tumor Antigens;Upper respiratory tract;Vaccinee;Vaccines;vector vaccine;Virus Diseases;Vision;Wild Type Mouse;Work

PROJECT_TITLE: Building the foundations of commensal vaccines

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J(70)R]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: PROVIDENCE

ORG_DEPT: BIOLOGY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE The goal of COBRE Center for Computational Biology of Human Disease is to enhance the research infrastructure for computational and bioinformatics analyses of biological research related to human disease. In this Phase 2 proposal we seek to strengthen the collaborations between laboratory scientists working with model systems and data scientists working with computational and bioinformatics tools to accelerate and sustain the implementation of translational medicine at Brown University and its affiliated hospitals. This is consistent with NIH’s mission of supporting bioinformatics and computational biology to advance all of biomedicine.

PI_NAMEs: RAND, DAVID M (contact)

PROGRAM_OFFICER_NAME: MATUKUMALLI, LAKSHMI KUMAR

PROJECT_TERMS: Acceleration;Address;Award;Biochemical;Bioinformatics;bioinformatics tool;Biological;Biological Models;biological research;Biology;Biomedical Research;Cell Physiology;cell type;Centers of Research Excellence;Clinical;Collaborations;Communities;Computational Biology;computer infrastructure;computerized tools;Creativeness;CRISPR/Cas technology;Data;data acquisition;Data Analyses;Data Scientist;deep learning;Disease;Drug resistance;Ensure;Environment;Faculty;Faculty Recruitment;Funding;Gene Expression;Gene Expression Profile;Genes;Genitalia;Goals;Grant;graph neural network;Growth;Hospitals;Human Biology;human disease;Infrastructure;innovation;Joints;Laboratory Scientists;Language;Maps;medical schools;member;Mentors;Mission;Modeling;Mucous Membrane;Multiomic Data;Neoplasm Circulating Cells;operation;Pathway interactions;Phase;Philosophy;Pilot Projects;Program Research Project Grants;programs;Proteins;reproductive;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Rhode Island;Science;Scientist;senior faculty;Services;Sexually Transmitted Diseases;single cell sequencing;skills;Software Engineering;Specificity;T cell differentiation;T cell regulation;T-Cell Development;Technology;Therapeutic;three dimensional cell culture;tissue resident memory T cell;Training;Training and Infrastructure;translational medicine;Tumor Cell Invasion;United States Department of Agriculture;United States National Institutes of Health;Universities;Vaccines

PROJECT_TITLE: COBRE: Center for Computational Biology of Human Disease


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Accountability;Administrative Coordination;Administrative Efficiency;Administrator;Advisory Committees;Award;Bioinformatics;Biological;Biology;biomedical informatics;Biomedical Research;career;career development;Centers of Research Excellence;Collaborations;Communication;Communities;community building;Computational Biology;Computational Molecular Biology;Computer Analysis;computer science;Computers;computing resources;cost;Data;Data Scientist;Dedications;Discipline;Effectiveness;Engineering;Ensure;Evaluation;Evaluation Reports;Faculty;faculty support;Funding;Future;genomic data;Genomics;Goals;Grant;High Performance Computing;Hospitals;Human Biology;human disease;Individual;Infrastructure;interest;Investments;Joints;Lead;Leadership;Learning;Life Cycle Stages;Medicine;meetings;Mentors;Methods;Office of Administrative Management;Peer Review;Phase;Pilot Projects;Program Evaluation;Program Sustainability;programs;Public Health;recruit;Reporting;Research;Research Personnel;Research Project Grants;Resources;Schedule;Schools;Science;Services;skills;statistical center;Strategic Planning;Structure;success;Support Groups;Time;Universities;Visualization

PROJECT_TITLE: Admin Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Diabetes;Stem Cell Research;Stem Cell Research - Embryonic - Human;Transplantation

ORG_CITY: MINNEAPOLIS

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative  We seek to develop a method for the long-term cryopreservation, or banking, of pancreatic islets prior to transplant. If successful this approach could revolutionize how islets are isolated, allocated, and stored prior to transplant. Further, it would help lessen the organ shortage problem, reduce the risk of transplantation, and improve islet transplantation's success rate for the cure of diabetes.

PI_NAMEs: BISCHOF, JOHN C;FINGER, ERIK BRIAN (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Adopted;advanced analytics;Affect;analytical method;Biological;Biology;Cells;Cellular Stress;Cessation of life;cGMP production;Chemicals;Clinical;clinical translation;cold temperature;cost;cryogenics;Cryopreservation;Cryoprotective Agents;Crystallization;Cyclic GMP;Data;Diabetes Mellitus;Disease;Dose;Engineering;Family suidae;Freezing;Glass;Goals;Health;Health Care Costs;Heating;Human;human stem cell-derived;Ice;Impairment;improved;In Vitro;in vivo;Individual;Infusion procedures;Injury;innovative technologies;Insulin;Interdisciplinary Study;islet;Islets of Langerhans;Islets of Langerhans Transplantation;Knowledge;Measures;Methods;Modeling;Molecular;Mus;Organ;Pathway interactions;Personal Satisfaction;Persons;Phenotype;potency testing;preservation;prevent;Procedures;Process;Protocols documentation;Recovery;repaired;Reporting;Resources;response;Rewarming;Risk;Risk Reduction;scale up;Source;stem cells;success;supply chain;Survival Rate;System;Technology;Testing;Tissues;Toxic effect;Translations;transplant centers;Transplantation;Validation;Whole Organism;Xenograft Model

PROJECT_TITLE: Engineering optimization and scaling enables high quality pancreatic islet cryopreservation for banking and transplant


ADMINISTERING_IC: DC

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Hearing Loss;Neurosciences;Rare Diseases;Usher Syndrome

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative Human hearing is mediated at the level of the hair cells within the inner ear, where the mechanical deflection of the hair bundles results in mechanotransduction. However, the mechanical element controlling the precise and sensitive channel opening is not known: the leading hypothesis for the identity of this element is the filamentous tip link connecting adjacent stereocilia within the hair bundles, which comprises a dimer each of protocadherin 15 (PCDH15) and cadherin 23 (CDH23). This study aims to elucidate the role of PCDH15 in both normal and pathological hearing.

PI_NAMEs: VILLASANTE, CAMILA MARIE (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Adult;Affect;Amino Acids;Behavior;Bilateral Hearing Loss;Binding;Binding Sites;biophysical properties;Cadherin Domain;CDH23 gene;Complex;congenital hearing loss;Data;deafness;Dependence;dimer;disulfide bond;Doctor of Philosophy;Elasticity;Electrons;Elements;Endolymph;Event;Exhibits;experience;experimental study;extracellular;Future;Genetic;Goals;Hair;Hair Cells;Hearing;hearing impairment;hereditary hearing loss;Human;in vivo;Individual;insight;Institution;Ion Channel;Ions;Laboratories;Labyrinth;Lead;Link;Measurement;mechanical properties;Mechanics;mechanotransduction;Mediating;Mediator;Mentorship;Molecular Conformation;monomer;Mutation;novel;optic trap;optical traps;Pathologic;Pathology;Patients;PCDH15 gene;physical property;Physicians;Physiological;prevent;programs;Property;Proteins;Ramp;response;Rod;Role;Scientist;Sensory;Series;single molecule;sound;Speed;stem;Stereocilium;Structure;supportive environment;Testing;treatment strategy;United States;Universities;Variant;Vestibular dysfunction;Work

PROJECT_TITLE: Protocadherin 15 as a critical component of the gating spring of human hearing


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences

ORG_CITY: AMES

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: Project Narrative Organophosphate nerve agents such as sarin, soman, and VX are classified as extremely lethal chemical warfare nerve agents (CWNA) likely to be abused in terrorism. The civilian populations are at risk if exposed to CWNA, which will cause deaths at high concentrations, but sublethal concentrations cause acute seizures and brain disorders for lifelong if not treated immediately. The current medical countermeasure (MCM) drugs alone are inadequate to prevent the long-term neurological problems, we, therefore, propose to test a combination of MCM and a neuroprotectant, saracatinib (a highly selective Fyn/Src kinase inhibitor which is in clinical trials for various cancers and Alzheimer's disease) or 1400W (a highly selective iNOS inhibitor), in a rat soman and VX model, and a Guinea pig model.

PI_NAMEs: THIPPESWAMY, THIMMASETTAPPA  (contact)

PROGRAM_OFFICER_NAME: SPRIGGS, SHARDELL M

PROJECT_TERMS: Acute;Address;Adverse effects;Aftercare;Alzheimer's Disease;Animal Euthanasia;Animal Model;Animals;Antiepileptogenic;Atropine;behavior test;Behavioral;Biological Assay;Brain;Brain Diseases;Brain Pathology;Cause of Death;Cessation of life;chemical threat;Chemical Warfare;cholinergic;Cholinesterase Inhibitors;Chronic;Classification;Clinical Trials;Cognitive;comorbidity;Consultations;conventional therapy;cytokine;Devices;Diazepam;Disease;Dose;drug development;Drug Interactions;Drug Targeting;drug testing;Drug toxicity;effective therapy;efficacy evaluation;Electroencephalography;England;Epilepsy;epileptiform;Euthanasia;Evaluation;experimental study;Exposure to;Family suidae;Female;Fostering;Functional disorder;Funding;Gliosis;global health;Goals;guinea pig model;Health;Histology;Hospitalization;Hospitals;Hour;Human;Impairment;Implant;improved;inhibitor;Intention;International;Investigational Drugs;kainate;kinase inhibitor;Lead;Letters;Long-Term Effects;Magnetic Resonance Imaging;Malaysia;male;Malignant Neoplasms;medical countermeasure;Midazolam;Mission;Modeling;Monitor;Motor;multiplex assay;nerve agent;Nerve Degeneration;neurobehavioral;neuroinflammation;Neurologic;neuron loss;neuropathology;neuroprotection;Neuroprotective Agents;neurotoxicity;Nitric Oxide Synthase;Nitric Oxide Synthetase Inhibitor;NOS2A gene;novel;Oral;Organophosphates;Ownership;Oximes;Pathway interactions;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Populations at Risk;Positron-Emission Tomography;pre-clinical;prevent;primary outcome;Process;Proto-Oncogene Proteins c-fyn;psychologic;Publications;Rattus;Recurrence;Regimen;Regulatory Affairs;Reporting;Research;research and development;Research Support;Sarin;Secure;Seizures;Serum;Soman;src-Family Kinases;Status Epilepticus;Stress;Survivors;Symptoms;Syria;Telemetry;Terrorism;Testing;Therapeutic;Time;Tokyo;Toxic effect;toxic organophosphate insecticide exposure;Tyrosine Kinase Inhibitor

PROJECT_TITLE: Saracatinib and 1400W Counteract Nerve Agents-Induced Long-Term Neurotoxicity


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Chronic Pain;Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Prescription Drug Misuse;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Substance Misuse

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative The addictive quality of opioid drugs is known to involve changes in the activity of neurons in the brain that utilize dopamine as a neurotransmitter. The search for drugs that can reverse such changes and potentially treat addiction to opioid drugs, as well as the search for analgesics that are devoid of addictive qualities, will be aided by model systems based on human cells. We aim to design such “organ-on-chip” model systems and use them to better understand the addictive process at a molecular level and to potentially identify new therapeutics to treat drug addiction and chronic pain.

PI_NAMEs: ASHAMMAKHI, NUREDDIN ;MAIDMENT, NIGEL T (contact);SEIDLITS, STEPHANIE KRISTIN;SVENDSEN, CLIVE NIELS

PROGRAM_OFFICER_NAME: KREPKIY, DMITRIY

PROJECT_TERMS: 3-Dimensional;abuse liability;Acute;addiction;Agonist;Analgesics;Anhedonia;Biological Availability;Biological Models;Blood - brain barrier anatomy;Brain;Brain-Derived Neurotrophic Factor;Butyric Acids;Cells;Characteristics;chemical resource;Chemicals;Chronic;chronic pain;Clinical;Coculture Techniques;Complement;craving;design;Detection;Development;Devices;Disinhibition;Dopamine;Drug Addiction;drug of abuse;Drug Screening;Engineering;Epidemic;Exposure to;extracellular;fabrication;Future;gamma-Aminobutyric Acid;Gene Expression;Gene Expression Profile;Genomic Library;Genomics;Goals;Human;human induced pluripotent stem cells;induced pluripotent stem cell;induced pluripotent stem cell technology;Inflammatory;innovation;insight;Intervention;Investigation;kappa opioid receptors;kinase inhibitor;Libraries;Liver;liver metabolism;Measures;Mediating;metabolomics;Microglia;microphysiology system;Midbrain structure;Modeling;Molecular;Morphine;mu opioid receptors;negative affect;Neurobiology;Neuronal Plasticity;Neurons;neurotransmission;Neurotransmitters;new therapeutic target;novel;novel strategies;novel therapeutics;Online Systems;Opioid;opioid abuse;Opioid agonist;opioid exposure;Opioid Receptor;opioid use disorder;opioid withdrawal;Organ;organ on a chip;Output;Pain;Pain management;pain-related disability;Pharmaceutical Preparations;Phase;Phosphotransferases;prescription opioid;prescription opioid misuse;prevent;Process;Property;Proto-Oncogene Proteins c-akt;Psychological reinforcement;Psychopathology;Public Health;Relapse;Resource Sharing;response;Risk Factors;Role;Route;scaffold;Scientist;screening;Screening procedure;sensor;Signal Pathway;Specificity;System;Testing;Therapeutic;Therapeutic Intervention;transcriptome sequencing;Translating;transmission process;treatment response;Withdrawal

PROJECT_TITLE: Multi-organ-on-chip device for modeling opioid reinforcement and withdrawal, and the negative affective component of pain: a therapeutic screening tool.


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Networking and Information Technology R&D (NITRD)

PI_NAMEs: WU, ZHIJIN JEAN (contact)

PROJECT_TERMS: Acceleration;Agreement;Award;big biomedical data;biobank;Bioconductor;Bioinformatics;Biological;Biomedical Research;Centers of Research Excellence;Clinical;Cloud Service;cohort;Communities;Computational Biology;Computer software;Core Facility;cost;Data;data access;Data Analyses;data management;Data Scientist;Data Set;data sharing;Development;diversity and inclusion;Education and Outreach;Educational workshop;Environment;Faculty;Fee-for-Service Plans;Funding;Future;Genome;genomic data;Genomics;Goals;Grant;High-Throughput Nucleotide Sequencing;Hospitals;Human;human disease;improved;Laboratories;Language;Mining;Modeling;Molecular;Phase;public database;Pythons;Reproducibility;Research;Research Infrastructure;Research Personnel;Research Support;Resources;Rhode Island;Science;service programs;Services;sharing platform;skills;Software Engineering;sustainable resource;Time;tool;Training;Translating;United States National Institutes of Health;Universities

PROJECT_TITLE: BioMedical Big Data Core


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Dissemination and Implementation Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pregnancy;Sleep Research;Women's Health Research

ORG_CITY: DETROIT

ORG_NAME: HENRY FORD HEALTH SYSTEM

ORG_STATE: MI

PHR: Project Narrative Half of pregnant women develop insomnia disorder, which is associated with high rates of comorbid depression. To address a severe lack of empirically supported treatment options for prenatal insomnia, we developed a mindfulness-based insomnia therapy specifically for pregnant women (Perinatal Understanding of Mindful Awareness for Sleep; PUMAS), and efficacy data suggest PUMAS produces large effects on insomnia and comorbid depression. The proposed project is an effectiveness-implementation hybrid type 1 pilot randomized controlled trial to test the feasibility, acceptability, and preliminary effectiveness of PUMAS, and to preliminarily investigate reductions in cognitive arousal as a key treatment mechanism by which PUMAS effectively alleviates clinical outcomes.

PI_NAMEs: KALMBACH, DAVID ADDISON (contact)

PROGRAM_OFFICER_NAME: CHU, SERENA PO-LAN

PROJECT_TERMS: acceptability and feasibility;Address;Aftercare;antidepressant effect;Arousal;Awareness;barrier to care;behavioral sleep intervention;Chronic;Client satisfaction;Clinic;Clinical;Cognitive;Cognitive Therapy;comorbid depression;Data;depressed patient;depressive symptoms;design;Diagnostic;diagnostic criteria;Disease remission;DSM-V;Effectiveness;effectiveness testing;effectiveness-implementation RCT;effectiveness/implementation hybrid;efficacious treatment;Elements;Ensure;Etiology;Evaluation;Exacerbated Insomnia;feasibility testing;Feedback;fetal;Fetal health;follow-up;Goals;Health system;Hybrids;implementation outcomes;improved;improvement on sleep;Intervention;Investigational Therapies;Link;Maintenance;Maternal Health;Mediator;meetings;Mental Depression;Mental disorders;Midwife;mindfulness;mindfulness intervention;Moods;National Institute of Mental Health;operation;Outcome;pandemic disease;Participant;patient expectation;Patients;Perinatal;perinatal intervention;Phase;Physicians;Placebos;Postpartum Depression;Postpartum Period;Predictive Factor;Pregnancy;pregnant;Pregnant Women;prenatal;Prenatal care;Process;Public Health;Randomized;Randomized, Controlled Trials;Refractory;Reporting;response;retention rate;rumination;Severities;Sleep;sleep difficulty;Sleeplessness;Symptoms;Telemedicine;Testing;therapy development;Thinking;Third Pregnancy Trimester;Translating;treatment effect;treatment response;Woman;Women's Health

PROJECT_TITLE: Improving Negative Stressful Perseverations in Insomnia to Revitalize Expecting Moms (INSPIRE)


ADMINISTERING_IC: MD

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Biomedical Imaging;Biotechnology;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Opioids;Osteoarthritis;Pain Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: TRUMBULL

ORG_NAME: ZETROZ SYSTEMS, LLC

ORG_STATE: CT

PHR: Project Narrative: This project proposes to clinically validate and commercialize wireless ultrasonic drug delivery technology for underserved minorities, minority United States Veterans and rural patients with chronic knee pain. The technology has been evaluated in the laboratory and the clinical setting with positive results. We will now finalize regulatory testing of the wireless system, and clinically evaluate the therapy in a multi-site long-term clinical efficacy study.

PI_NAMEs: LEWIS, GEORGE KENNETH (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: active duty;active method;Adoption;Adverse effects;Affect;Age Years;Aging;aging population;American;Animal Model;arm;Arthralgia;Arthritis;arthropathies;Articular Range of Motion;biomaterial compatibility;black patient;Cardiovascular system;Caring;celecoxib;Chronic;chronic pain;Client satisfaction;Clinical;Clinical effectiveness;clinical efficacy;Clinical Research;Clinical Trials;Combined Modality Therapy;commercialization;Cost Analysis;Coupled;Coupling;Cream;cytotoxicity;Data;Degenerative polyarthritis;demographics;design;Devices;Diathermy;Diclofenac;disability;disabled;Disease;Drug Controls;Drug Delivery Systems;Drug Kinetics;Drug Utilization;Economic Burden;Economics;Effectiveness;efficacy study;ethnic diversity;ethnic minority;Exercise;Family suidae;Federal Government;Formulation;gastrointestinal;Growth;Health;Health Benefit;Health Care Costs;health disparity;Health Professional;Hispanic;Histopathology;Home;Hour;Human body;human subject;improved;Incidence;indexing;innovation;Insurance Carriers;Insurance Coverage;Intervention;Joints;Kidney;Knee Osteoarthritis;knee pain;Laboratories;Life;Life Expectancy;Location;manufacturability;manufacture;Marketing;Measures;Medical;microbial;Military Personnel;military veteran;miniaturize;miniaturized device;minimal risk;Minority;Minority Groups;Narcotics;Non-Steroidal Anti-Inflammatory Agents;Not Hispanic or Latino;Numeric Rating Scale;Opiate Addiction;opioid epidemic;Oral;Oral Administration;osteoarthritis pain;Outcome Measure;Outcome Study;Pain;Pain management;pain reduction;pain relief;pain scale;pain score;Participant;participant enrollment;patient population;Patient-Focused Outcomes;Patients;Penetration;Phase;phase 1 study;Placebo Control;placebo group;Placebos;Play;Population;Predisposition;Prevalence;primary outcome;Production;Quality of life;racial minority;radiological imaging;Randomized;Regulatory Pathway;Reporting;research clinical testing;Role;rural patients;Safety;Series;Services;Site;Small Business Innovation Research Grant;Soldier;standard of care;Statistical Data Interpretation;study population;Symptoms;System;Technology;Testing;Tissues;Transdermal substance administration;treatment group;Ultrasonics;ultrasound;underserved minority;United States;United States National Institutes of Health;usability;Validation;Veterans;Walking;Water;Western Ontario and McMaster Universities Arthritis Index;wireless;wireless electronic

PROJECT_TITLE: Clinical Optimization of Ultrasonic Drug Delivery Technologies for Underserved Minority US Veterans in Chronic Pain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-G(13)B]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Women's Health Research

PI_NAMEs: WONG, IAN Y (contact)

PROJECT_TERMS: 3-Dimensional;Affect;Biochemistry;Biocompatible Materials;Bioinformatics;Biological Assay;Biomedical Engineering;Blood Circulation;bone;Bone Marrow Stem Cell;Breast Cancer Cell;cancer cell;Cell Communication;cell motility;cell type;Cells;Cellular Spheroids;Centers of Research Excellence;Coculture Techniques;colonization resistance;Computational Biology;Confocal Microscopy;Cultured Tumor Cells;Data;Disease Progression;Distant;Drug resistance;Drug Screening;Engineering;Epithelium;Estrogen receptor positive;Exhibits;Extracellular Matrix;Family suidae;Fibroblasts;Fibroins;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genetic Transcription;genomic profiling;Goals;Heterogeneity;high throughput screening;Homing;Human;human disease;Individual;inhibitor;Invaded;Liver;Lung;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;mechanical stimulus;Mechanics;Mentors;Mesenchymal;Metastatic Neoplasm to the Bone;Microfluidics;Micrometastasis;mimetics;Modeling;Morphology;National Institute of Biomedical Imaging and Bioengineering;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;Organ;Outcome;Patients;Pattern;Pharmaceutical Preparations;Phenotype;pre-clinical;Primary Neoplasm;programs;Proliferating;Research;Research Personnel;Research Project Grants;response;Sampling;self assembly;Silk;single cell analysis;Site;Sorting;spatiotemporal;Stimulus;Stromal Cells;Technology;Therapeutic;therapy resistant;Tissue constructs;Tissues;Traction;transcriptome sequencing;transcriptomic profiling;tumor microenvironment;Validation;Xenograft procedure

PROJECT_TITLE: Project 2: Profiling Gene Expression and Mechanophenotype in Circulating Tumor Cells Ex Vivo


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Immunotherapy;Pancreatic Cancer;Rare Diseases

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE As current immunotherapies boost T cells to kill cancers, they are ineffective in ~80% of tumors that contain too few T cells (“cold” tumors). We have identified a new immunotherapy to activate a new immune cell called group 2 innate lymphoid cells (ILC2s), which increase T cells to control pancreatic cancer, a deadly cold tumor. We now propose to study how ILC2s increase T cells in pancreatic cancer, so that we may identify better ways to activate ILC2s in immunotherapies.

PI_NAMEs: BALACHANDRAN, VINOD P (contact);MERGHOUB, TAHA

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Activated Lymphocyte;Active immunity;Biology;Cancer Biology;CD8-Positive T-Lymphocytes;cell motility;Cell Physiology;Cells;Cellular biology;chemokine;Clinical Trials;cytokine;Data;Dendritic Cells;density;Engineering;Ensure;experience;Future;Genetic;Goals;Human;Immune;immune checkpoint;Immunity;immunogenic;Immunology;Immunooncology;Immunotherapy;Infection;Infiltration;Institution;Interleukins;Ligands;Lymphocyte;Lymphoid Cell;Malignant neoplasm of pancreas;Malignant Neoplasms;migration;Modeling;Molecular;Morals;mouse model;multidisciplinary;Mus;Nature;Neoplasm Metastasis;novel;Oncology;Organoids;Pancreatic Ductal Adenocarcinoma;Pathway interactions;Patients;PD-1 blockade;Pharmaceutical Preparations;Phenotype;programmed cell death protein 1;Proteins;rare cancer;recruit;Regulation;Reporting;Research Personnel;response;restraint;Sampling;skills;stem cells;Survivors;T-Cell Activation;T-Lymphocyte;tertiary lymphoid organ;Testing;Th2 Cells;therapeutic target;Tissues;tool;transcriptomics;Transgenic Organisms;translational potential;tumor;Tumor Immunity;Tumor Necrosis Factor-Beta

PROJECT_TITLE: Group 2 Innate Lymphoid Cell Regulation of Pancreatic Cancer Immunity

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ORG_CITY: Newark

ORG_DEPT: PATHOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Tissue-resident memory T lymphocytes are a population of cells that are poised to encounter and eliminate pathogens as they attempt to invade the intestine and other mucosal surfaces. Understanding conditions that support differentiation and function of this important cell population will provide insight into how vaccination strategies can be modified to elicit protective immune responses.

PI_NAMEs: BERGSBAKEN, TESSA  (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Adipose tissue;Area;Biological Models;Biological Process;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Maintenance;Cells;Cellular biology;Chromatin;Complement;Complex;design;Disease;enteric pathogen;Epigenetic Process;Gene Expression Profile;Generations;gut colonization;Heterogeneity;Histone Acetylation;HIV;human pathogen;Immune;Immune response;Immunity;Impairment;Individual;Infection;Inflammation;Inflammatory;insight;Integrins;interest;Interleukin-12;Intestines;Invaded;Knowledge;Laboratories;Lamina Propria;Liver;Location;Maintenance;Mediating;Memory;Metabolic;Metabolism;Microbe;Modeling;Mucosal Immunity;mucosal vaccine;Mucous Membrane;Mus;Mycobacterium tuberculosis;Pasteurella pseudotuberculosis;pathogen;Phenotype;Play;Population;prevent;Primary Infection;Proliferating;recruit;Regulation;response;Role;secondary infection;Secondary to;Signal Transduction;single-cell RNA sequencing;STAT4 gene;STAT4 protein;Surface;T cell differentiation;T cell response;T memory cell;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Time;Tissue Differentiation;tissue resident memory T cell;Tissues;tool;Transcriptional Activation;Translating;Vaccination;vaccination strategy;vaccine efficacy;Work

PROJECT_TITLE: Differentiation and function of intestinal tissue-resident memory T cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(57)]


PI_NAMEs: DE VITO, ROBERTA  (contact)

PROJECT_TERMS: Biological;Biological Factors;Biological Sciences;Biology;Brain;Breathing;cancer type;Centers of Research Excellence;Communities;Complex;Computational Biology;Data;data reduction;Data Science;design;dimension reduction;Dimensions;Experimental Designs;experimental study;Factor Analysis;Foundations;Genes;genomic data;Genomics;Goals;high dimensionality;human disease;Learning;Logistic Regressions;Machine Learning;Malignant Neoplasms;Measurement;Measures;Meta-Analysis;Methodology;Methods;Morphologic artifacts;multidimensional data;novel;Population;Positioning Attribute;Regression Analysis;Reproducibility;Research;Signal Transduction;software development;Software Tools;Source;Statistical Methods;Statistical Models;Structure;Techniques;technology development;Time;Tissues;tool;Variant;Work

PROJECT_TITLE: Recovering reproducible and local signal in genomic data


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences;Pediatric;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHOLOGY

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: Project Narrative Cognitive impairments in mathematics affect a significant percentage of children (6%). Some argue that mathematics impairments are more common in girls than boys but this claim is debated. Prior research has not compared the biological markers of mathematics development between gender groups during early childhood. Our research program uses neuroimaging techniques to identify biological markers of mathematics learning in 4- to 8-year-old boys and girls. We also examine the role of early spatial learning, gender socialization, and home learning activities in the neural development of mathematics.

PI_NAMEs: CANTLON, JESSICA F (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: 7 year old;8 year old;Affect;Age;Area;Basic Science;Behavior;Behavioral;Behavioral Research;Biological;Biological Markers;boys;Brain;Child;Child Behavior;Child Development;Cognition;Cognitive;cognitive development;cognitive neuroscience;comparative;comparison control;Competence;Data;Development;Diagnosis;early childhood;Education;Environment;experience;experimental study;Functional Magnetic Resonance Imaging;Gender;gender difference;girls;Growth;Home;Image;Impaired cognition;Impairment;Individual Differences;Inferior frontal gyrus;innovation;insight;intraparietal sulcus;Learning;learning strategy;Link;Longitudinal Studies;Magnetism;mathematical ability;mathematical learning;mathematical theory;Mathematics;Measures;Methods;Nature;neural;neural patterning;neurodevelopment;neuroimaging;neuromechanism;Neurosciences;novel;Pattern;Performance;Process;programs;Psyche structure;Psychology;reading ability;Research;Resolution;Role;Rotation;Schools;Short-Term Memory;skills;Socialization;Specificity;Statistical Methods;Structure;Support System;Techniques;Testing;Time;trait;Variant;verbal

PROJECT_TITLE: Gender, Early Spatial Cognition, and the Neural Basis of Mathematics in Children


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Breast Cancer;Cancer;Lymphatic Research;Lymphedema;Prevention;Women's Health Research

ORG_CITY: LITTLE ROCK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Project Narrative Doxorubicin is a chemotherapeutic drug commonly used in breast cancer but is associated with a major complication called lymphedema, which is debilitating to patients. Our project explores how doxorubicin directly inhibits contractions of lymph vessels, which remove fluid from tissues to prevent lymphedema. There are no known medications to alleviate DOX-related lymphedema; however, we have identified a potential new target for anti-lymphedema medications.

PI_NAMEs: STOLARZ, AMANDA  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: 3-Dimensional;Acute;Attenuated;Breast Cancer Patient;Breast Cancer therapy;breast surgery;Calcium Channel;Cancer Patient;cancer risk;cancer type;Cell Death;Cell Death Induction;chemotherapy;Chronic;clinically relevant;Complication;copper zinc superoxide dismutase;Development;Doxorubicin;Drug usage;Enzymes;Generations;Healthcare Systems;Histologic;Immobilization;Impairment;in vivo;Incidence;Injury;interstitial;knock-down;Ligation;Lipid Peroxidation;lipidomics;Liquid substance;Lymph;lymph flow;lymph nodes;lymph stasis;Lymphatic;lymphatic circulation;lymphatic dysfunction;Lymphatic function;lymphatic insufficiency;lymphatic surgery;lymphatic vessel;Lymphedema;Malignant Breast Neoplasm;Malignant Female Reproductive System Neoplasm;Malignant Neoplasms;Mediating;Mesentery;Mitochondria;Modeling;Monitor;Morphology;Muscle Cells;new therapeutic target;novel;Operative Surgical Procedures;optical imaging;overexpression;oxidation;Pathway interactions;Patients;Perfusion;Periodicity;Persons;Pharmaceutical Preparations;pre-clinical;Pre-Clinical Model;preclinical study;preservation;pressure;prevent;Proteins;Radiation;Radiation Dose Unit;Rattus;receptor;Receptor Activation;recurrent infection;Research;response;Risk;risk mitigation;Role;Ryanodine Receptor Calcium Release Channel;RyR1;RyR3;Sarcoplasmic Reticulum;Second Primary Cancers;Signal Transduction;small hairpin RNA;SOD2 gene;Speed;Sulfhydryl Compounds;Superoxides;Surgical Models;Techniques;Therapeutic;therapeutic target;Tissues

PROJECT_TITLE: Ryanodine Receptors as Therapeutic Targets to Prevent Doxorubicin-Induced Lymphatic Dysfunction

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Dissemination and Implementation Research;Health Services;Hypertension;Neurodegenerative;Neurosciences;Patient Safety;Prevention;Primary Health Care;Telehealth

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PUBLIC HEALTH RELEVANCE: Improving blood pressure (BP) control may represent an important public health strategy for lowering the risk of dementia. We hypothesize that a health-system wide approach with home BP monitoring and a “virtual” collaborative care clinic will safely and effectively lower BP and slow age-related decline in cognition while reducing cardiovascular events and risk, mortality, and health care utilization. If this approach effectively overcomes the numerous barriers to effective BP control, it would have significant public health implications.

PI_NAMEs: BURNS, JEFFREY MURRAY;GUPTA, ADITI  (contact);WAITMAN, LEMUEL RUSSELL

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: Adherence;Administrator;Adopted;Adoption;Adverse effects;Age-associated memory impairment;Agreement;Algorithms;Alzheimer's disease related dementia;American;American Heart Association;Anti-Hypertensive Agents;Atherosclerosis;Blood Pressure;blood pressure control;Blood Pressure Monitors;blood pressure reduction;Cardiology;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Caring;Clinic;Clinic Visits;clinical care;Clinical Pharmacists;Clinical Trials;Cognition;cohort;Collaborations;collaborative care;college;Communication;cost;dashboard;Dementia;dementia risk;design;Dose;Education;effectiveness evaluation;effectiveness trial;effectiveness/implementation study;Electronic Health Record;Eligibility Determination;Enrollment;Ensure;Event;Foundations;Frequencies;Future;Goals;Guidelines;health care service utilization;Health system;Healthcare;High Prevalence;Home;Home Blood Pressure Monitoring;human old age (65+);Hypertension;hypertension control;Impaired cognition;implementation outcomes;implementation science;implementation study;improved;Incentives;Incidence;Institution;Institutional Review Boards;Intention;Intervention;Kansas;Knowledge;Manuals;Measures;mild cognitive impairment;mobile application;Modeling;mortality;multidisciplinary;new technology;older adult;older patient;operation;Outcome;participant enrollment;Patients;Pharmacists;Pharmacy facility;Phase;phase 2 testing;Positioning Attribute;pragmatic implementation;pragmatic trial;Prevalence;prevent;Prevention;Primary Care;primary care clinic;primary outcome;Procedures;Process;programs;Public Health;public health relevance;Randomized;Recommendation;Recording of previous events;recruit;remote monitoring;Reproducibility;Resources;Risk;Safety;Sample Size;satisfaction;secondary outcome;Secure;shared decision making;Site;Structure;System;Testing;Time;Transportation;treatment as usual;Universities;Utah;virtual;virtual delivery

PROJECT_TITLE: Remote Monitoring and Virtual Collaborative Care for Hypertension Control to Prevent Cognitive Decline


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Genetics;Human Genome;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pulmonary Hypertension;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE The main focus of our research is studying the role of SHH-FOXF1 and TBX4-FGF10 signaling pathways in epithelial-mesenchyme interactions during human lung development as well as in etiology of lethal lung developmental disorders (LLDD) and pulmonary arterial hypertension (PAH) in neonates. In particular, we are interested in an interplay between the pathogenic coding variants and the regulatory non-coding regulatory elements of the FOXF1, FENDRR, TBX4, and FGF10 genes, implied in complex compound inheritance of these disorders. We hypothesize that (i) non-coding variants are promising therapeutic target and (ii) that a little known transmembrane protein TMEM100 mediates SHH-FOXF1 and TBX4-FGF10 signaling during human lung development.

PI_NAMEs: STANKIEWICZ, PAWEL  (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Alleles;Alveolar;Alveolar capillary dysplasia with misalignment of pulmonary veins;Appearance;Autopsy;Binding Sites;Biological Assay;Biopsy;Cell Line;Childhood;ChIP-seq;Chromosome 16;Classification;Code;Complex;Congenital alveolar dysplasia;Copy Number Polymorphism;Data;Development;Developmental Gene;Diagnosis;diagnostic biomarker;Disease;disease phenotype;Distant;DNA Binding;Dysplasia;Electrophoretic Mobility Shift Assay;Embryo;Endothelium;Enhancers;Epithelium;Etiology;Family;fetal;FGF10 gene;FGFR2 gene;FOXF1 gene;Genes;Genetic;Genetic Counseling;genetic variant;genome editing;heart defect;Heterozygote;Histologic;Histones;Human;Human Cell Line;Human Genetics;hypoxia neonatorum;in utero;Infant;insight;Integral Membrane Protein;interest;Life;Lung;lung development;lung developmental disorder;malformation;Maps;Mediating;Mediator;Mesenchymal;Mesenchyme;Modification;mouse model;Mus;Mutate;neonate;novel;novel diagnostics;Nucleic Acid Regulatory Sequences;Paracrine Communication;Pathogenesis;Pathogenicity;Patients;Penetrance;Phase;Phenotype;Play;prevent;Process;Prognosis;Prognostic Marker;promoter;Promoter Regions;pulmonary arterial hypertension;pulmonary hypoplasia;Regulatory Element;Reporting;Research;Resolution;RNA Interference;Role;SHH gene;Signal Pathway;Signal Transduction;Signaling Molecule;Single Nucleotide Polymorphism;Specimen;Techniques;Technology;therapeutic target;transcription factor;transcriptome sequencing;Translating;Untranslated RNA;Variant

PROJECT_TITLE: Etiology and pathogenesis of lethal lung developmental disorders in neonates

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Infectious Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: Pittsburgh

ORG_NAME: MAGEE-WOMEN'S RES INST AND FOUNDATION

PHR: PROJECT NARRATIVE Our nation is currently nearly paralyzed by the twin pandemics of COVID-19 and inequities in health outcomes among Americans of differing ethnicities affected by COVID-19; so, to address these, we seek sponsorship for this initiative—entitled FRONTIERS IN EMERGING, REEMERGING AND ZOONOTIC DISEASES AND DIVERSITY (FrERZD2)—to train a new generation of pandemic and emerging disease researchers by providing urgent and essential knowledge and the abilities necessary to manage pandemic responses. This training course, offered at Morehouse School of Medicine and Ponce Health Sciences University (a Historically Black College or University and a Hispanic Serving Institution, respectively) will launch and sustain three vital undertakings: sophisticated courses for skills development, addressing the causes, prevention and healing strategies for dealing with pandemics at the national level; relevant vital research experiences addressing these national threats; and career-mentoring activities to promote the careers of specialists in relevant biomedical professions. FrERZD2, responsive to PAR-20-289 (NIAID Research Education R25 Program), is designed for graduate and medical students, medical residents, postdoctoral fellows, and/or early- career faculty and to enhance and expand the research careers of the most promising scientists, with sensitivity to ensuring full diversity in the NIAID workforce.

PI_NAMEs: SCHATTEN, GERALD  (contact)

PROGRAM_OFFICER_NAME: MOTEN, CARMEN

PROJECT_TERMS: Address;Advisory Committees;African American;American;Appointment;Area;Authorization documentation;biomedical profession;Black race;career;career development;Clinical;Collaborations;cost effective;COVID-19;COVID-19 impact;COVID-19 pandemic;Creativeness;design;Diagnostic;Disease;early-career faculty;Education;Education Projects;education research;Educational Activities;Educational process of instructing;Educational workshop;Ensure;ethical, legal, and social implication;Ethics;Ethnic Origin;Exercise;experience;Faculty;Fostering;frontier;Funding;Generations;genetic approach;Goals;graduate school;graduate student;Guidelines;healing;health care disparity;health inequalities;Health Personnel;Health Sciences;Healthcare Systems;Hispanic Americans;Hispanic-serving Institution;Historically Black Colleges and Universities;Hybrids;improved;Inequity;innovation;Institution;Instruction;Investigation;Investments;Knowledge;Laboratories;Laboratory Research;lectures;Medical;medical schools;Medical Students;member;Mentors;Methods;minority scientist;minority trainee;Minority-Serving Institution;Molecular;Morehouse School of Medicine;Names;National Institute of Allergy and Infectious Disease;next generation;Outcome;Pain;pandemic disease;pandemic response;Paralysed;Participant;Patient Recruitments;Physicians;Postdoctoral Fellow;Prevention;programs;recruit;Research;Research Personnel;responsible research conduct;Scientist;Senior Scientist;Series;skill acquisition;Specialist;Technology;Therapeutic;Training;Training Programs;Twin Multiple Birth;Underrepresented Minority;underrepresented minority student;Universities;virtual education;Woman;ZIKA;Zoonoses

PROJECT_TITLE: Frontiers in Emerging, Reemerging and Zoonotic Diseases and Diversity (FrERZD2)


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Liver Disease;Organ Transplantation;Social Determinants of Health;Substance Misuse;Transplantation

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE Early liver transplantation (eLT), defined as LT evaluation with <6 months of alcohol abstinence, is associated with acceptable outcomes for patients with severe alcohol-associated liver disease (ALD) in retrospective studies. However, prospective, multi-center data including biopsychosocial factors on eLT for all patients with ALD in racially, culturally, and socioeconomically diverse populations are lacking. The INTEGRATE collaborative is a highly diverse investigative team that seeks to: 1) define factors influencing referral and waitlisting for eLT in ALD (selection); 2) identify which biopsychosocial factors are causally related and predictive of outcomes most important to stakeholders (outcomes); and 3) determine how integrated care among the healthcare team influences stakeholder-relevant outcomes in eLT for ALD (management).

PI_NAMEs: GOLDBERG, DAVID SETH (contact);SOLLE, NATASHA

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Abstinence;access disparities;Address;alcohol abstinence;Alcohol consumption;alcohol use disorder;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Behavioral Research;Biological Factors;biopsychosocial;biopsychosocial factor;candidate selection;career;Caregivers;Caring;Cirrhosis;Clinical;cohort;Communication;County Hospitals;Data;data harmonization;design;ethnic diversity;Ethnic Origin;Evaluation;Family;Focus Groups;Funding;Geographic Locations;health care disparity;health disparity;Hepatitis;improved;innovation;integrated care;Interview;Knowledge;Liver diseases;liver transplantation;Longitudinal cohort;Measures;Medical;Medical Care Team;Medical center;Medicine;member;Mental Health;Methodology;Methods;Michigan;Modeling;multidisciplinary;National Institute on Alcohol Abuse and Alcoholism;novel;organ allocation;Organ Donor;Organ Procurements;Outcome;outcome prediction;Pathway interactions;Patient Care;patient population;Patient-Focused Outcomes;Patients;Perception;Population;Population Heterogeneity;Positioning Attribute;preference;Process;prospective;Protocols documentation;Provider;Psychological Factors;Qualitative Evaluations;Race;racial diversity;Recurrence;Research;Research Methodology;Research Personnel;Resource Allocation;Resources;Retrospective Studies;Risk;risk prediction model;sex;social health determinants;socioeconomics;Sodium Chloride;stakeholder perspectives;Standardization;substance use;Surveys;survival prediction;Techniques;Texas;Time;transplant centers;transplant model;Transplantation;Underinsured;United States National Institutes of Health;Universities;virtual;Waiting Lists;Work

PROJECT_TITLE: 3/4-The INTEGRATE Study: Evaluating INTEGRATEd Care to Improve Biopsychosocial Outcomes of Early Liver Transplantation for Alcohol-Associated Liver Disease


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Asthma;Clinical Research;Lung;Machine Learning and Artificial Intelligence;Pediatric;Prevention

ORG_CITY: BLOOMINGTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Early life metabolic dysregulation has lasting consequences on the developing infant immune system and lung, and these changes likely underlie the pathobiology of childhood atopy and wheeze (an early manifestation of allergy and asthma). Knowledge gaps remain in understanding the pathobiological mechanisms of atopy and wheeze phenotypes, which the proposed study aims to address by computationally integrating metabolome and immune response data to identify molecular pathways relevant to the pathobiology of atopic and wheeze phenotypes. Biomarker and pathway identification will aid in identifying targets for primary prevention of allergy and asthma syndromes in the pediatric population, which is of high public health priority.

PI_NAMEs: TURI, KEDIR NESHA (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: Acute respiratory infection;Address;airway inflammation;Amino Acids;Anti-Inflammatory Agents;Antioxidants;Arachidonic Acids;Asthma;atopy;Bilirubin;Biological Availability;Biological Markers;Birth;career development;Childhood;Chronic Disease;cohort;Computing Methodologies;Data;data integration;Development;Development Plans;Disease;disorder prevention;Dose;early childhood;Early identification;Environment;Environmental Exposure;experience;Fatty Acids;Feces;Goals;Heme;Hypersensitivity;Immune;Immune response;Immune system;in utero;Incidence;infancy;Infant;Inflammation;Inflammatory;insight;interest;Knowledge;Life;lipid mediator;lipidome;Lipids;Lung;Metabolic;Metabolic Pathway;metabolome;metabolomics;Molecular;molecular subtypes;multiple omics;Nose;novel;oxidation;Oxidative Stress;Pathogenesis;Pathway Analysis;Pathway interactions;Pattern;Phenotype;Plasma;Population;population based;Primary Prevention;Property;public health priorities;Pulmonary Inflammation;Recurrence;Research;Research Personnel;Resolution;response;Risk;Role;statistics;supervised learning;Syndrome;System;Systems Biology;Testing;Time;Training;two-dimensional;United States National Institutes of Health;unsupervised learning;Urine;Wheezing;Work

PROJECT_TITLE: Identification of Early Metabolomic and Immune Endotypes of Allergy and Asthma: An Integrated Multiomics Approach


ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE Proteins that utilize the iron-containing heme cofactor play essential transport, enzyme, and signaling functions in physiology. Our research will provide new information about how the heme cofactor, which is made inside the cell mitochondria, is transported for delivery to proteins that use heme throughout the cell. This research is highly relevant to the mission of NIGMS to increase our understanding of biological processes and to investigate how living systems work from the molecular to the cellular level, and it is also medically relevant for understanding physiology and a broad number of diseases like anemia, asthma, autoimmunity, infections, and inherited diseases.

PI_NAMEs: STUEHR, DENNIS J (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: ABCG2 gene;Anabolism;Anemia;Asthma;Autoimmunity;Azoles;Binding;Biological;Biological Process;Biotinylation;Cardiovascular system;Cell Culture Techniques;Cell membrane;Cells;Charge;Chimeric Proteins;cofactor;Complex;crosslink;Crystallization;Crystallography;CYP2D6 gene;CYP3A4 gene;Cytochrome P450;Dioxygenases;Disease;Drug Controls;Electron Transport;Enzymes;Eukaryota;Event;experimental study;Goals;Health;Heme;heme a;heme oxygenase-1;heme oxygenase-2;Hemeproteins;Hemoglobin;Hereditary Disease;Human;Immune system;indoleamine;Infection;Iron;Kinetics;Knowledge;Lung;Mammalian Cell;Mammals;Medical;Mission;Mitochondria;Modification;Molecular;Molecular Chaperones;Monitor;Mutagenesis;mutant;Myoglobin;NADPH Oxidase;National Institute of General Medical Sciences;Neurologic;Nitric Oxide Synthase;Organism;Oxygenases;particle;Pathway interactions;Peroxidases;Pharmaceutical Preparations;Physiology;Play;Production;Property;protein complex;protein function;protein purification;Proteins;Publishing;reconstitution;Regulation;Research;Role;sensor;Signal Transduction;Site;Soluble Guanylate Cyclase;Source;Steroid biosynthesis;Structure;Surface;System;Testing;trafficking;Transport Process;tumor;Vasodilation;Work;Yeasts

PROJECT_TITLE: Defining a pathway for mitochondrial heme trafficking

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Translational research in Artificial Intelligence (AI) has been hindered by the lack of shared data resources with sufficient depth, breadth and diversity. There are very limited EHR datasets freely available to the general research community especially the AI research community through direct download with credential-based access. We aim to establish a large cross-CTSA collaborative data sharing for critical care by leveraging the existing CTSA collaborative networks. With the diversified racial, ethnic and geographic profiles from the above CTSAs, with inpatient, outpatient, and ICU data pre-, during and post- ICU admissions, we will provide the data foundation to support fair and generalizable algorithms for advanced patient monitoring and decision support. We will also develop a series of novel AI algorithms to fully leverage the data and advance translations. The proposed project will provide best practice guidance to and set up exemplary examples for nationwide CTSAs. It will also support the cultivation of next generation medical AI researchers.

PI_NAMEs: CIMINO, JAMES J;LUO, YUAN  (contact);PAYNE, PHILIP R.O.;WILLIAMS, ANDREW EWING

PROGRAM_OFFICER_NAME: RADMAN, THOMAS C

PROJECT_TERMS: Acceleration;Acute Renal Failure with Renal Papillary Necrosis;Admission activity;Algorithms;Artificial Intelligence;artificial intelligence algorithm;autoencoder;Benchmarking;Categories;Clinical;clinical application;Clinical Data;clinical translation;Clinical Trials;Communities;Community Health Education;course module;Credentialing;Critical Care;Critical Illness;Data;data access;data de-identification;data modeling;Data Set;data sharing;data sharing networks;Data Sources;deep learning;deep learning model;Disadvantaged;Disease;driving force;Elements;Environment;Ethnic Origin;Exclusion;Fast Healthcare Interoperability Resources;federated learning;firewall;Foundations;Geographic Locations;Geography;Graph;Growth;Health Insurance Portability and Accountability Act;Health protection;high risk;Hospitals;Informatics;innovation;Inpatients;Institution;Intensive Care;Intervention;Learning;learning strategy;Libraries;Machine Learning;machine learning model;Medical;Memory;Methodology;Methods;Modeling;multimodality;National Center for Advancing Translational Sciences;Network-based;next generation;Nosocomial pneumonia;novel;open source;Outcome;Outpatients;Patient Monitoring;Patient-Focused Outcomes;Patients;Phenotype;Population;Practice Guidelines;programs;Race;racial diversity;Rare Diseases;repository;Research;Research Personnel;Resources;Risk;Series;Site;Structure;structured data;Testing;Text;Time;Training and Education;Translational Research;Translations;Variant;Vision;Width;Work

PROJECT_TITLE: CRITICAL: Collaborative Resource for Intensive care Translational science, Informatics, Comprehensive Analytics, and Learning


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative The goal of this study is to support patients with hypertension self-management using both home blood pressure monitors and digital messaging programs. We will first engage patients with uncontrolled hypertension in technology training to use home monitors, online portal websites to view their medical record information online, and texting and mobile phone applications. Then we will assess the effectiveness of home blood pressure monitors and enhanced patient-clinician digital communication on blood pressure control during a 12-month intervention.

PI_NAMEs: LYLES, COURTNEY REES (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Adoption;African American population;American;Anti-Hypertensive Agents;arm;automated text message;Blood Pressure;blood pressure control;Blood Pressure Monitors;burden of chronic illness;Caring;Cellular Phone;Clinic;Clinical;Clinical Pharmacists;Communication;cost;COVID-19;COVID-19 pandemic;Data;Diagnosis;digital;digital communication;digital divide;digital healthcare;digital technology;digital tool;Disparity;effectiveness evaluation;effectiveness/implementation hybrid;Electronic Health Record;Eligibility Determination;Equity;ethnic minority;Ethnic Origin;evidence base;Goals;Health;health care availability;health care settings;Health Personnel;Healthcare Systems;Heart failure;Home;Home Blood Pressure Monitoring;Hypertension;hypertension control;implementation outcomes;improved;Income;Infrastructure;Integrated Delivery of Health Care;Integrated Delivery Systems;interest;Intervention;Latinx population;Life;Limited English Proficiency;literacy;Literature;Low income;Maintenance;Measurement;Measures;Medical Records;Methods;Monitor;monitoring device;Myocardial Infarction;National Heart, Lung, and Blood Institute;Outcome;pandemic disease;patient engagement;patient population;patient portal;patient subsets;patient-clinician communication;Patients;Persons;Pharmaceutical Preparations;Population Heterogeneity;post-pandemic;primary care clinic;primary care team;primary outcome;programs;Protocols documentation;Provider;provider communication;racial disparity;racial minority;Randomized;randomized trial;randomized, clinical trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;remote health care;remote intervention;remote monitoring;safety net;San Francisco;Secure;Self Management;Site;skills;smart home;socioeconomics;Spanish/English;standard care;Stroke;System;tailored text messaging;Technology;technology intervention;technology training;telehealth;Text;Text Messaging;Time;timeline;Training;treatment as usual;uptake;Visit;web portal;web site;wireless;Work

PROJECT_TITLE: Remote monitoring for Equity in Advancing Control of Hypertension (REACH)

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: NEW HAVEN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE This project aims to use high-throughput and high-resolution single-cell and spatial omics technologies to characterize senescent cell heterogeneity and environments. It will generate multiscale molecular and cellular maps of cellular senescence in primary and secondary human lymphoid organs, representing a highly valuable data resource to improve our understanding of cellular senescence in development, aging, and disease.

PI_NAMEs: FAN, RONG  (contact);HALENE, STEPHANIE

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Adopted;age related;Aging;analysis pipeline;Area;Articulation;Atlases;Biological;Biological Markers;Biological Models;biomarker identification;Biomedical Engineering;Bone Marrow;Cell Aging;Cell Cycle Arrest;cell type;Cells;Collaborations;Communities;Computer software;Copyright;Data;Data Analytics;data resource;data sharing;data submission;Dedications;design;Development;Dimensions;Disease;empowerment;Ensure;Environment;experience;Fostering;Functional impairment;Generations;Goals;Grant;hallmarks of aging;healthspan;Hematology;Hematopoiesis;Heterogeneity;Histopathology;Human;human tissue;Image;Immune;immune function;Immunobiology;improved;Informatics;insight;Intervention;Kidney;Licensing;life span;Liver;Lung;lymph nodes;lymphoid organ;Lymphoid Tissue;Maps;member;Metadata;Modeling;Molecular;molecular imaging;molecular scale;Molecular Target;Motivation;multidisciplinary;new technology;Organ;Organoids;Physicians;Physiology;Play;Policies;primary lymphoid organ;programs;Proteins;Publications;Published Comment;Publishing;Quality Control;regenerative healing;repaired;Research;Research Activity;Research Priority;Resolution;Resource Sharing;Resources;Risk;Role;Scientist;secondary lymphoid organ;senescence;senescence associated secretory phenotype;senescent cell;single molecule;Specimen;Standardization;Stress;synergism;Techniques;Technology;tertiary lymphoid organ;Thymus Gland;Tissue Expansion;tissue mapping;Tissues;Tonsil;tool;transcriptome;transcriptome sequencing;Translating;United States National Institutes of Health;Validation;Visualization;wound healing

PROJECT_TITLE: Yale TMC for Cellular Senescence in Lymphoid Organs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(70)R]


NIH_SPENDING_CATS: Aging;Lymphatic Research

PI_NAMEs: FAN, RONG  (contact)

PROJECT_TERMS: Acceleration;Aging;aging related disease;Agreement;Area;Atlases;Biological Assay;biomarker development;Biomedical Engineering;Biomedical Research;Bone Marrow;Calendar;Cell Aging;Cells;Chronic;Chronic Disease;Clinical;Collaborations;Communication;Communities;Complex;Confounding Factors (Epidemiology);Data;data access;data dissemination;data format;data integration;data sharing;Decision Making;Development;Disease;Educational workshop;Ensure;Environment;Evaluation;Event;experience;experimental study;Generations;genome-wide;Grant;Group Meetings;Hematology;Heterogeneity;Histopathology;Human;human tissue;Immune;Immunobiology;Immunology;Impairment;improved;Inflammation;Injury;Institution;Intellectual Property;Interest Group;Joints;Journals;Laboratories;Leadership;lymph nodes;lymphoid organ;Malignant - descriptor;mange;Maps;meetings;Metadata;Mission;Modality;Modeling;Monitor;Motivation;multidisciplinary;neoplastic cell;Online Systems;operation;Organ;organizational structure;outreach;Physicians;Physiological;Physiological Processes;Physiology;Policies;Predisposition;prevent;Procedures;Production;programs;Proliferating;Protocols documentation;Publications;Research;Research Activity;Research Personnel;Resource Sharing;Role;sample collection;Schedule;Scientist;senescent cell;Site;Standardization;Structure;synergism;System;targeted treatment;Technology;Testing;Therapeutic Intervention;Thymus Gland;tissue mapping;Tissues;Tonsil;United States National Institutes of Health;Update;Work;working group;wound healing

PROJECT_TITLE: Core A: Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Narrative Inherited retinal degenerations and age-related macular degeneration affect more than two million people in the United States. For 90% of the people afflicted with these diseases, no treatments have been developed. This project will study the role of a transcription factor STAT3 in regulating mechanisms that slow retinal degeneration. Knowledge from this study will ultimately lead to new therapies to treat retinal degenerations.

PI_NAMEs: ASH, JOHN D (contact);ELLIOTT, MICHAEL H

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Affect;Age related macular degeneration;antagonist;Binding;biological adaptation to stress;Blindness;Cell Death;cell type;Cells;Cessation of life;ChIP-seq;cytokine;Cytoprotection;Data;data integration;Data Set;design;differential expression;Disease;Disease Clusterings;FGF2 gene;Gene Expression;Genes;Genetic Transcription;Gliosis;Individual;Inflammation;Inflammatory;inherited retinal degeneration;Injections;injured;Injury;Knockout Mice;Knowledge;Lead;LIF gene;LIFR gene;Light;Mediating;Methods;Microglia;migration;Modeling;Muller's cell;Mus;Mutation;NF-kappa B;novel therapeutics;Pathologic;Persons;Photoreceptors;Phototransduction;Play;promoter;Publications;Publishing;Quality of life;receptor;Regulation;Research;Resistance;response;Retina;Retinal Degeneration;retinal neuron;retinal rods;Rod;Role;Signal Transduction;single-cell RNA sequencing;Site;Sorting;Stress;stress state;Techniques;Testing;Tissues;Transcription Coactivator;transcription factor;Transcriptional Activation;Transcriptional Regulation;Transducers;United States;Work

PROJECT_TITLE: Transcriptional control of stress-induced resistance to retinal degeneration

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Aging;Clinical Research;Data Science;Hematology;Lymphatic Research

PI_NAMEs: HALENE, STEPHANIE  (contact)

PROJECT_TERMS: adaptive immune response;Age;age related;aged;Aging;Aliquot;Antigens;Biological;Biological Markers;Biomedical Research;Blood;Blood Cells;Blood specimen;Bone Marrow;Bone Tissue;Catalogs;Cell Aging;Cell Cycle Arrest;Cell Maturation;Cells;Clinical;clinical care;Collaborations;Collection;Communities;comorbidity;Data;Data Analyses;Data Science;Databases;Environment;Erythrocytes;Excision;Functional impairment;Gender;Goals;hallmarks of aging;Health;health data;Health Insurance Portability and Accountability Act;Hematology;Hematopoiesis;Hematopoietic System;Heterogeneity;hip replacement arthroplasty;Histologic;Homeostasis;Human;Human body;human tissue;Immune;immune function;Immunobiology;improved;Individual;Individual Differences;Infrastructure;insight;interest;Invaded;Kidney;Knowledge;Laboratories;life span;Link;Liver;Lung;lymph nodes;lymphoid organ;Lymphoid Tissue;Maintenance;Maps;Medicine;Metadata;microorganism;Molecular;Motivation;Multiomic Data;multiple omics;Operative Surgical Procedures;Organ;Organism;participant enrollment;particle;Particulate;Pathologic;Pathology;Patients;Pharmaceutical Preparations;Pharyngeal structure;Phenotype;Physiological;Physiology;Play;Preparation;primary lymphoid organ;Process;Protocols documentation;Race;regenerative healing;Research;Research Personnel;Role;Sampling;secondary lymphoid organ;senescence associated secretory phenotype;senescent cell;Specimen;Spleen;Stream;Stress;Structure;Subjects Selections;synergism;System;T-Lymphocyte;Thymus Gland;Tissue Banks;tissue mapping;Tissue Sample;Tissues;Tonsil;Training;United States National Institutes of Health;wound healing

PROJECT_TITLE: Core B: Tissue Specimen Core


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative Many biologically important sequences of ribonucleic acid (RNAs) fold into speciﬁc 3D structures conserved through evolution, but knowing when an RNA sequence includes a conserved RNA structure is not trivial and depends on clues left behind by conservation: covariation and variation. We have developed state of the art methods based on evolutionary conservation to identify when a conserved RNA sequence includes a conserved structure (R-scape), and to predict the RNA structure of those that have one (CaCoFold); these methods are more accurate and have fewer false predictions than other previous methods, which makes them suitable for the detection and analysis of conserved RNA structures in complex eukaryotic genomes. We propose three lines of research: to systematically identify novel structural RNAs in vertebrates with special emphasis on the experi- mental characterization of those involved in human health and disease; to produce novel methods to accurately determine their 3D structure; and to produce next generation methods exploiting pre-covariation signals to detect novel primate-speciﬁc structural RNAs relevant to human health.

PI_NAMEs: RIVAS, ELENA  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: 3-Dimensional;Adopted;Algorithms;Amino Acid Sequence;Attention;Bacteria;Base Pairing;Bioinformatics;Biological;Biological Process;Biology;causal variant;Cell Extracts;Cell Physiology;Cells;Characteristics;Chromatography;Complex;computerized tools;Computing Methodologies;Coupled;deep learning;Detection;Disease;Enzymes;Escherichia coli;Evolution;Exhibits;expectation;fungus;Genetic Epistasis;Genetic Transcription;Genome;genome wide screen;genome-wide;Genomics;Health;Human;Human Biology;Human Genome;improved;insight;Knowledge;Left;Life;Machine Learning;MALAT1 gene;mammalian genome;Markov Chains;Mediating;Methodology;Methods;MicroRNAs;model organism;Mutation;Names;next generation;novel;Peptides;Phylogenetic Analysis;Phylogeny;Play;Positioning Attribute;preservation;Primates;programs;protein structure prediction;Proteins;Publications;Publishing;Recording of previous events;Reporter Genes;Research;Ribosomal RNA;RNA;RNA Splicing;Role;Saccharomyces cerevisiae;Sequence Alignment;Signal Transduction;Small Nucleolar RNA;Structure;System;targeted treatment;Technology;Telomerase;Testing;therapeutic development;three dimensional structure;tool;Transcript;Translations;Triplet Multiple Birth;Untranslated Regions;Untranslated RNA;Variant;vertebrate genome;Vertebrates;virtual;Virus;Work

PROJECT_TITLE: Discovery of structural RNAs involved in human health and disease

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Disability Research;Health Services;Pain Research;Physical Activity;Physical Rehabilitation;Rehabilitation

ORG_CITY: DURHAM

ORG_DEPT: ORTHOPEDICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative The proposed research is directly relevant to public health as it aims to advance the clinical management of patients with patellar tendinopathy, a common chronic musculoskeletal pain condition that results in reduced physical activity and quality of life, by applying an innovative whole person healthcare intervention approach. This research is relevant to the NIH mission to improve patient-oriented long-term outcomes by moving beyond outdated traditional unifocal clinical care models towards comprehensive and individualized care models. The expected outcome of this research seeks to stimulate a shift in current treatment strategies and outcomes for patients with chronic musculoskeletal pain conditions.

PI_NAMEs: PIETROSIMONE, LAURA STANLEY (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: acceptability and feasibility;Address;Adopted;appropriate dose;Behavioral;Benchmarking;Biofeedback;Biological;Biomechanics;biopsychosocial;Cancer Burden;career;Caring;Case Series;Chronic;chronic care model;Chronic Disease;chronic musculoskeletal pain;Clinical;clinical care;Clinical Management;Clinical Research;Clinical Trials;Comprehensive Health Care;Data;design;Development;Diabetes Mellitus;Disabilities experience;disability;Economic Burden;effective intervention;efficacy evaluation;Enrollment;Etiology;evidence base;Exercise;Exercise Therapy;experience;Fostering;Frequencies;Funding;Future;Goals;Health;Healthcare;Heart Diseases;high risk;improved;Individual;innovation;Intervention;intervention refinement;Interview;K-Series Research Career Programs;Knee;Knowledge;Lead;Literature;Manuals;Measurement;Measures;Mechanics;Mental Health;Mentors;Methodology;Methods;Military Personnel;Mission;model design;Modeling;Movement;multimodality;Musculoskeletal;Musculoskeletal Pain;novel;Outcome;Outcomes Research;Pain;patellar tendon;Pathway interactions;Patient Care;patient engagement;patient oriented;patient population;Patient Self-Report;Patient-Focused Outcomes;Patients;Performance;Personal Satisfaction;personalized care;Physical activity;physical conditioning;Physical Function;pragmatic trial;primary outcome;Procedures;programs;progressive care;Protocols documentation;psychologic;psychological distress;Public Health;Quality of life;randomized, clinical trials;randomized, controlled study;Randomized, Controlled Trials;recruit;Rehabilitation therapy;Research;retention rate;Safety;secondary outcome;social;standard of care;Standardization;Structure;Symptoms;Techniques;Tendinopathy;Tendon structure;Testing;Therapeutic Intervention;therapy development;Tissues;tool;traditional care;Training;treatment group;Treatment outcome;treatment strategy;United States National Institutes of Health;wearable sensor technology;whole health;Work;years lived with disability

PROJECT_TITLE: Developing a Novel Clinical Care Model for Chronic Patellar Tendinopathy Utilizing Whole Person Healthcare

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: KLUGER, YUVAL  (contact)

PROJECT_TERMS: Algorithms;Atlases;Basic Science;Bioinformatics;Biological;Biological Assay;Biological Markers;biomarker signature;Catalogs;Cell Aging;cell type;Cells;Clinical Pathology;Clinical Research;Communities;Computer Analysis;computer infrastructure;computerized data processing;Core Facility;Data;Data Analyses;data analysis pipeline;Data Coordinating Center;data infrastructure;data integration;data management;data resource;Data Set;data sharing;data standards;Data Storage and Retrieval;data to knowledge;data visualization;Databases;Deposition;Development;Environment;Ethnic Population;feature selection;Female;Generations;Genes;Genomics;Goals;graphical user interface;Heterogeneity;high dimensionality;Histologic;Histology;Human;Human BioMolecular Atlas Program;Image;imager;Informatics;informatics infrastructure;Ligands;Link;lymphoid organ;Lymphoid Tissue;male;Maps;Measures;member;Messenger RNA;Metadata;Methodology;Mission;Modality;Molecular;multidimensional data;multimodal data;multiple omics;next generation;Online Systems;Pathology;Pathway interactions;portability;Process;Proteins;Proteomics;Protocols documentation;quality assurance;receptor;Resolution;sample collection;Sampling;senescence;senescence associated secretory phenotype;senescent cell;software development;Statistical Data Interpretation;System;Technology;Tissue Sample;Tissue Stains;Tissues;transcriptome sequencing;transcriptomics;Translational Research;United States National Institutes of Health;Visualization;web portal;Work

PROJECT_TITLE: Core D: Data Analysis Core


ORG_CITY: TAHLEQUAH

ORG_NAME: CHEROKEE NATION

ORG_STATE: OK

PHR: Narrative American Indian communities suffer disproportionately from a range of health disparities. Cherokee NARCH will expand authentic tribal capacity to address these disparities through a coordinated program of student career enhancement, capacity building, and research/pilot research activities directly providing research experiences for students in the Cherokee Nation setting. /

PI_NAMEs: KHAN, SOHAIL IMRAN (contact)

PROGRAM_OFFICER_NAME: RICHARDS, CRYSTAL LYNETTE

PROJECT_TERMS: Address;Advisory Committees;Affect;American Indian community;American Indian Population;American Indian Tribe;American Indians;bariatric surgery;Bariatrics;Biomedical Research;career;career development;Cherokee Indian;Cherokee Nation;Clinical;Code;college;Data;Degenerative polyarthritis;Development;Disparity;Education;Ensure;Environment;Environmental Risk Factor;Epigenetic Process;ethical, legal, and social implication;Evaluation;evidence base;experience;Faculty;Foundations;Funding;Genomics;Goals;Health;health application;Health Disparities Research;health disparity;Health Occupations;Health Services;Health Surveys;Immersion;improved;Indigenous;Infrastructure;innovation;interest;Leadership;Machine Learning;Medical Research;medical schools;Mentorship;Metabolic;Mission;Monitor;Native American Research Center for Health;next generation;Non-Insulin-Dependent Diabetes Mellitus;Oklahoma;Operative Surgical Procedures;Osteopathic Medicine;Patients;Policies;Population;Procedures;programs;Psychologist;Psychology;Public Health;Research;Research Activity;Research Personnel;Research Project Grants;Reservations;Risk;Scientist;student participation;Students;success;System;Training;tribal Nation;Tribes;undergraduate student;United States Indian Health Service;Universities;Work

PROJECT_TITLE: Cherokee Nation Native American Research Centers for Health (NARCH) 11

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-Y(55)]


NIH_SPENDING_CATS: Clinical Research;Emergency Care;Health Services;Hematology;Infectious Diseases;Pediatric;Prevention;Sepsis;Social Determinants of Health

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE/RELEVANCE TO PUBLIC HEALTH Sepsis is a life-threatening disease caused by infection that affects many children around the world and can frequently result in the failure of organs in the human body (for example, the lungs, heart, or kidneys). The current criteria to identify children with sepsis are outdated and have many limitations. We propose building a large database containing clinical information about children from both high-income countries and low- and middle-income countries to develop new criteria for sepsis in children using measures of organ function.

PI_NAMEs: BENNETT, TELLEN  (contact);SANCHEZ-PINTO, LAZARO NELSON

PROGRAM_OFFICER_NAME: JENKINS, TAMMARA L

PROJECT_TERMS: Acceleration;Accident and Emergency department;Address;Adult;Advisory Committees;Affect;Bangladesh;Caring;Cessation of life;Child;Childhood;China;Clinical;clinical care;Clinical Data;clinical decision support;Colombia;computing resources;Country;Critical Care;Critically ill children;Data;data resource;Databases;design;Development;Diagnosis;Disease;Early Diagnosis;Early identification;effective therapy;Electronic Health Record;Emergency Care;Environment;Functional disorder;global health;health care availability;Health Priorities;Heart;high risk;Hospital Mortality;Human body;Immune response;improved;improved outcome;Income;Infection;innovation;inpatient service;Inpatients;Institution;Intensive Care Units;International;Kidney;Life;low and middle-income countries;Lung;Measures;Medicine;mobile application;Modeling;mortality;mortality risk;novel;Organ;Organ failure;Patients;pediatric emergency;Pediatric Hospitals;pediatric sepsis;prototype;Public Health;Publishing;Resource-limited setting;Resources;response;risk stratification;Role;Science;Sepsis;Site;Societies;Specificity;support tools;System;Systemic Inflammatory Response Syndrome;Techniques;temporal measurement;unnecessary treatment;Update;Work

PROJECT_TITLE: Novel Pediatric Sepsis Criteria and Clinical Decision Support Tools

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-Z(02)]


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health

PROJECT_TERMS: Address;Advisory Committees;Affect;Ally;American Indians;anti-cancer research;Attention;career;Cherokee Indian;Cherokee Nation;Communication;Complex;Decision Making;Development;Ensure;Fostering;Foundations;Funding;Funding Opportunities;Future;Goals;Health;health disparity;Healthcare Systems;implementation process;improved;Infrastructure;Institution;Institutional Review Boards;Joints;Leadership;Location;Medical Research;Mentors;Native American Research Center for Health;Native Americans;novel;Oklahoma;Procedures;Process;Program Evaluation;programs;Research;Research Activity;Research Project Grants;Resources;shared decision making;Structure;Students;success;System;Training;Training Activity;tribal community;tribal health;Tribally Based Participatory Research;Tribes;United States;Universities

PROJECT_TITLE: Cherokee NARCH Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-Y]


NIH_SPENDING_CATS: Aging;Bioengineering;Genetics;Human Genome;Lymphatic Research;Social Determinants of Health

PROJECT_TERMS: 3-Dimensional;Acceleration;age related;aged;Aging;Animals;Atlases;Biological;Biological Assay;biomarker identification;Biomedical Research;Blood Vessels;Body Fluids;Bone Marrow;Books;Catalogs;Cell Aging;Cell Cycle Arrest;Cell model;Cell secretion;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chemicals;Collaborations;Complex;Data;data integration;Development;Disease;Engineering;Environment;ethnic minority population;experience;Female;Functional impairment;Gene Expression;hallmarks of aging;healthspan;Hematopoiesis;Heterogeneity;Human;human imaging;human tissue;Image;imager;imaging detection;Immune;immune function;improved;insight;Kidney;life span;Liver;Lung;Lymph Node Tissue;lymph nodes;lymphoid organ;Lymphoid Tissue;male;Maps;Measures;Messenger RNA;Molecular;molecular imaging;Molecular Profiling;Molecular Target;Motivation;multimodality;multiple omics;Neighborhoods;new technology;Organ;Phenotype;phenotypic biomarker;Physiological;Physiology;Play;primary lymphoid organ;protein expression;Protein Secretion;Proteins;regenerative healing;repaired;Reporting;Resolution;Resources;response;Role;secondary lymphoid organ;senescence;senescence associated secretory phenotype;senescent cell;senolytics;senomorphic;single cell proteins;single molecule;single-cell RNA sequencing;Stains;Stress;Stromal Cells;synergism;System;Technology;Thymus Gland;Time;tissue fixing;Tissue Model;Tissues;Tonsil;tool;Training;transcriptome;transcriptome sequencing;transcriptomics;wound healing

PROJECT_TITLE: Core C: Biological Analysis Core


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Pediatric;Prevention;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research;Youth Violence;Youth Violence Prevention

ORG_STATE: PA

PHR: PROJECT NARRATIVE This project seeks to determine whether a stakeholder-informed intervention delivered via a chatbot can be an effective means to reduce suicide risk among cyberbullied adolescents, focusing especially on underserved youth. By intervening proximally to incidents of cyberbullying when adolescents are vulnerable to suicidal ideation, this research has significant potential for public health impact. Ultimately, this research will inform the feasibility and initial efficacy of a digital just-in-time suicide prevention intervention for cyberbullied adolescents.

PI_NAMEs: BIERNESSER, CANDICE L (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Acute;Address;Adolescence;Adolescent;Affect;Age;Algorithms;behavioral health;brief motivational intervention;bullying;career;Cause of Death;chatbot;Clinical;Clinical Trials;Clinical Trials Design;coping;COVID-19 pandemic;cyberbullying;Data;design;Development;Devices;digital;digital intervention;digital mental health;digital tool;Distress;distress tolerance;efficacious intervention;emotional experience;Environment;Ethics;Ethnic Origin;Evaluation;Exhibits;experience;Feasibility Studies;feasibility testing;Feedback;Feeling suicidal;follow-up;Goals;Health;Health Care Costs;help-seeking behavior;high risk;Hospitalization;human centered design;improved;innovation;Intervention;Interview;Investigation;investigator training;iterative design;K-Series Research Career Programs;Knowledge;Life Cycle Stages;Link;machine learning algorithm;machine learning model;Mediation;Mental Health;Mental Health Services;Mentors;Methods;minority children;Motivation;motivational enhancement therapy;multidisciplinary;Outcome;Parents;patient oriented;peer influence;prevent;preventive intervention;primary outcome;Problem Solving;prototype;psychological distress;Public Health;Questionnaires;Race;recruit;reducing suicide;Reporting;Research;retention rate;Sampling;satisfaction;Schools;Scientist;secondary outcome;service delivery;Sexual and Gender Minorities;skills;Social Interaction;social media;Social Problems;Social Workers;Structure;suicidal;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide prevention;suicide rate;Testing;theories;therapy design;therapy development;Time;Training;usability;vulnerable adolescent;Youth

PROJECT_TITLE: Development and Testing of imHere4U: A Digital Suicide Prevention Intervention for Cyberbullied Adolescents


NIH_SPENDING_CATS: American Indian or Alaska Native;Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PI_NAMEs: CHEN, SIXIA  (contact)

PROJECT_TERMS: Adult;Age;Agreement;American;American Indian Population;American Indians;Area;Behavior;Behavioral;Behavioral Risk Factor Surveillance System;behavioral study;Calibration;Cherokee Indian;Cherokee Nation;cigarette smoking;Clinic;Code;Communities;Community Health;Community Surveys;Complex;County;Cross-Sectional Studies;Data;Data Files;data integration;data quality;Data Set;data sharing;Data Sources;design;Diabetes Mellitus;Disparity;Educational workshop;Environmental Risk Factor;Ethnic Population;experience;Funding;Future;Geographic Factor;Geographic Information Systems;Geography;Goals;Health;Health behavior;Health Surveys;High Prevalence;improved;Individual;innovation;Institutional Review Boards;Machine Learning;meetings;Methodology;Methods;Modeling;multidisciplinary;multilevel analysis;multiple data sources;Native American Research Center for Health;Not Hispanic or Latino;novel;Obesity;Oklahoma;Outcome;Performance;Population;Population Analysis;population based;population health;Prevalence;Probability Samples;Procedures;programs;Public Health;Publications;racial population;Research;Research Personnel;Risk Factors;Sample Size;Sampling;Selection Bias;Shapes;Smoking;Source;Surveys;symposium;Testing;therapy development;Tobacco;Tobacco use;tool;Training;Tribes;United States Indian Health Service;Update;Work;Youth

PROJECT_TITLE: Using a Novel Machine Learning Based Data Integration Procedure to Understand the Cherokee Nation Community Population Health