NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: NARRATIVE Enhancer regulatory elements play essential roles in development and cell function through gene regulation, and dysregulation of enhancers contributes to various human diseases. The objective of this research program is to investigate the regulations of enhancer dynamics and assembly in response to signaling and their functional importance. The resulting insights will advance our understanding of disease mechanisms and identify potential therapeutic targets for enhancer-related diseases.

PI_NAMEs: LIU, ZHIJIE "JASON"  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Acute;Affect;Behavior;Binding;Bioinformatics;Biological Models;Biotin;candidate identification;Cell Physiology;Cells;Chromatin;Chronic;Chronic Disease;combinatorial;Development;Disease;Disease Progression;DNA;Enhancers;ESR1 gene;Fluorescence;Foundations;Gene Expression;Gene Expression Regulation;genetic approach;Genetic Transcription;Genomic approach;Grant;Hormone Receptor;hormone therapy;Hormones;human disease;imaging approach;imaging system;in vivo;innovation;insight;Label;Ligand Binding;Malignant Breast Neoplasm;Mediating;Molecular;multiple omics;National Institute of General Medical Sciences;Phase;Physical condensation;Play;Prevention approach;programs;protein protein interaction;Proteins;Regulation;Regulatory Element;Research;Resistance;response;Role;Series;Signal Transduction;Site;System;Tamoxifen;Technology;therapeutic target;Tissues;transcription factor;Transcriptional Activation

PROJECT_TITLE: Mechanisms of enhancer dynamics and assembly in gene regulation


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: AUSTIN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative In this project, small molecule fluorophores will be developed for monitoring the localization and metalation state of metalloenzymes in cells with a focus on zinc-dependent enzymes. Results of these studies will provide insight into the physiological and pathological roles of metalloenzymes in several biological contexts including antibiotic resistant infections and oxidative stress and will aid in the development of therapeutic strategies.

PI_NAMEs: QUE, EMILY L (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Active Sites;Affinity;Antibiotic Resistance;antibiotic resistant infections;Award;beta-Lactamase;Binding;Biological;Biological Process;carbonate dehydratase;Cell Physiology;Cells;chemical reaction;clinically relevant;Complex;design;Diagnostic;Disease;Environment;Enzymes;Escherichia coli;Fluorescence;Fluorescent Probes;fluorophore;Goals;Grant;Health;high-throughput drug screening;Homeostasis;Human;improved;inhibitor;insight;interest;Investigation;Ions;Knowledge;Ligation;metal chelator;Metal Ion Binding;metalloenzyme;Metalloproteins;Metals;Micronutrients;Molecular Probes;Monitor;multiplexed imaging;Nutritional Immunity;Organism;Oxidative Stress;Pathologic;Pathology;Physiological;Property;Proteins;Proteome;Research;response;Role;Site;small molecule;Stimulus;Therapeutic;therapeutic development;Zinc

PROJECT_TITLE: Molecular probes for cellular investigation of metalloenzymes

STUDY_SECTION: MRAE

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - E Study Section[MRAE]


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project narrative: Throughout animal biology, cell-cell communication mechanisms are carefully regulated to ensure proper tissue formation and avoid diseases. Our research combines biochemistry, biophysics, and cell biology to learn how a critical family of cell-cell communication molecules known as G protein-coupled receptors operate within the primary cilium, an essential solitary hair-like structure on the surface of nearly all cells. A deeper understanding of these processes will provide insights into how cells send and receive signals to one another, teach us how animal tissues are generated and maintained, reveal the molecular basis for several common human genetic diseases affecting many organ systems, and aid in the development of more effective and durable therapeutic agents for a range of devastating pathologies.

PI_NAMEs: MYERS, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Adult;Affect;animal tissue;Animals;Binding;Binding Proteins;Biochemical;Biochemistry;Biological Process;Biology;Biophysics;Body System;Cardiovascular system;Catalytic Domain;Cell Communication;cell communication molecule;Cell surface;Cells;Cellular biology;Cholesterol;Cilia;Code;Congenital Abnormality;Cyclic AMP-Dependent Protein Kinases;Development;Diagnostic;Disease;Educational process of instructing;Ensure;Environment;Erinaceidae;Family;Foundations;Functional disorder;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Generations;Genetic Diseases;Hair;Health;hedgehog signal transduction;Homeostasis;Human Genetics;in vivo;insight;Integral Membrane Protein;Investigation;Learning;Lipids;Malignant Neoplasms;Membrane;Modeling;Molecular;Musculoskeletal System;Nervous System;novel;operation;Organ;Pathologic;Pathology;Pathway interactions;Phase;Phosphorylation;Phosphotransferases;Physiological;Physiology;Post-Translational Protein Processing;Process;programs;receptor;Research;Role;Seminal;Shapes;Signal Transduction;Site;Specific qualifier value;Sterols;Structure;Surface;System;Testing;Therapeutic;Therapeutic Agents;Tissues;tool;Transducers;transmission process;Work

PROJECT_TITLE: G protein-coupled receptor signaling in development and disease: Hedgehog and beyond

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


ADMINISTERING_IC: NR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health

ORG_CITY: PULLMAN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: PROJECT NARRATIVE  To meet the needs of the growing adult population who manage chronic health conditions, we propose to enhance our clinician-in-the-loop smart environment to prevent and treat condition exacerbations. We will design conformal prediction methods to forecast future exacerbations. Additionally, we will analyze the impact of external events like the COVID-19 pandemic and frequent wildfires on behavior, socialization, environment, and health state. For all of our machine learning tasks, we will train language models from nurse summaries to provide text explanations of observed behavior and machine learning predictions.

PI_NAMEs: COOK, DIANE JOYCE (contact);FRITZ, ROSCHELLE

PROGRAM_OFFICER_NAME: MCNAMARA, KAREN MARIE

PROJECT_TERMS: Acceleration;Accounting;Adult;Age;aging related;Algorithms;Apple watch;Behavior;behavior change;behavioral response;Caring;Chronic;Clinical;clinical translation;Cognitive;Communities;Computer software;COVID-19 pandemic;Data;Data Collection;data fusion;Data Sources;demographics;design;Detection;Education;Effectiveness;empowerment;Environment;Event;Future;Goals;Health;health equity;Health Promotion;Health Status;Healthcare Systems;Home;improved;Individual;Informatics;innovation;insight;Intervention;Joints;Language;language training;lens;Life;Link;Machine Learning;machine learning model;machine learning prediction;Methods;model design;Modeling;Monitor;multidisciplinary;Neighborhoods;Nurses;Nursing Models;older adult;open source;Outcome;Pacific Northwest;Participant;Patients;Pattern;Performance;personalized intervention;Population;prevent;Prevention;prospective;Prospective Studies;Quality of life;Recommendation;remote location;remote monitoring;Research;Research Personnel;response;risk prediction;Sample Size;Self Management;sensor;smart environment;smart home;smart watch;Smoke;social health determinants;Social isolation;Socialization;Societies;Suggestion;Support System;Symptoms;System;Techniques;Technology;Text;Time;Training;Triage;Trust;underserved community;United States National Institutes of Health;Visualization;wearable data;wearable sensor technology;Wildfire;Work

PROJECT_TITLE: A clinician-in-the-loop smart environment to support management of chronic health conditions

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Hematology

ORG_CITY: LOS ANGELES

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE This proposal focuses on using a combination of biochemistry and proteomic mass spectrometry to understand how iron metabolism is coordinately regulated to generate an integrated cellular response to changes in iron availability. Considering defects in iron metabolism have been linked to many diseases including anemias, hemochromatosis, and cancer, the elucidation of these pathways will have important implications for understanding the molecular basis of these disorders.

PI_NAMEs: WOHLSCHLEGEL, JAMES AKIRA (contact)

PROJECT_TERMS: Address;Amino Acids;Anemia;Area;Biochemistry;Biological;Biological Process;Cell Physiology;Cell Respiration;Cues;Defect;Disease;Ensure;Eukaryotic Cell;Hemochromatosis;human disease;Investigation;Iron;iron metabolism;Laboratories;Link;Lipids;Malignant Neoplasms;Mass Spectrum Analysis;Methods;Molecular;novel;nucleic acid metabolism;Nucleotides;oxygen transport;Pathway interactions;Physiological;programs;Proteomics;Regulation;Regulatory Pathway;Research;response;Signal Transduction;Toxic effect;Ubiquitin;ubiquitin-protein ligase

PROJECT_TITLE: Understanding Ubiquitin-dependent Regulation of Iron Metabolism using Mass Spectrometry

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-H (56)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project Narrative While o ering the potential to answer important questions in biology and medicine, modern genomic and biomed- ical datasets are complex and massive. Extracting insights from modern genomic and biomedical datasets requires the development of expressive and scalable statistical and computational methods. Our work will lead to power- ful tools to understand the interplay understand how evolutionary processes shape the genome and how genetic variation a ects trait variation within homogeneous and admixed populations.

PI_NAMEs: SANKARARAMAN, SRIRAM  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Admixture;African;Algorithms;analytical tool;Biological;Biology;Complex;Computing Methodologies;cost;Data;Data Set;deep learning;Development;Disease;disorder risk;DNA sequencing;Evolution;Genes;Genetic;genetic architecture;Genetic Variation;Genome;Genomics;Goals;Health;Human;Human Genome;improved;Individual;insight;Medicine;Modeling;Modernization;Phenotype;Population;Population Genetics;Process;Quantitative Genetics;Recording of previous events;reference genome;Research;Sample Size;Shapes;statistical and machine learning;Statistical Methods;Statistical Models;Structure;tool;trait;Variant;Work

PROJECT_TITLE: Expressive and scalable statistical models for genomic and biomedical data

STUDY_SECTION: MRAF

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - F Study Section[MRAF]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Inappropriate regulation of protein phosphatases can lead to aberrant cellular behavior, resulting in a variety of disease phenotypes including diabetes, obesity, aging-related disorders, and various forms of cancer. The proposed studies aim to provide transformative insights into the molecular mechanisms by which the PP2A family protein phosphatases respond to environmental stimuli, potentially paving the way for the development of novel targeted therapies.

PI_NAMEs: KONG, MEI  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Address;aging related;Animal Model;cell behavior;Cells;Complex;Development;Diabetes Mellitus;Disease;disease phenotype;Environment;extracellular;Family;Goals;Homeostasis;innovation;insight;Knowledge;Malignant Neoplasms;Metabolic;Molecular;new therapeutic target;novel;Obesity;operation;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physiological;programs;Protein Dephosphorylation;Protein Family;Protein Kinase;Protein phosphatase;protein phosphatase 6;Protein Serine/Threonine Phosphatase;Proteins;Regulation;Research;response;Serine;Signal Pathway;Signal Transduction;Specificity;Stimulus;Substrate Specificity;System;Threonine

PROJECT_TITLE: Regulatory Mechanisms of PP2A Family Phosphatases


NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome

ORG_CITY: SANTA CRUZ

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: Project Narrative: The research program we propose will pursue two main focus areas with the overall goal of expanding the capabilities of long-read sequencing technology to benefit human health research. In the first focus area, we will generate highly detailed tissue and cell-type transcriptome annotations for human and mouse. In the second, we will develop an easy-to-use, ultra-accurate, and read-length agnostic sequencing method to meet the needs of a broader research community.

PI_NAMEs: VOLLMERS, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Address;Area;Biological Assay;Biological Sciences;Biomedical Research;cell type;Communities;Computing Methodologies;Democracy;DNA sequencing;Ecosystem;Funding;Genes;Genomics;Goals;Health;High-Throughput DNA Sequencing;High-Throughput Nucleotide Sequencing;Human;Knowledge;Length;Methods;Molecular Biology;Molecular Computations;Mus;nanopore;programs;Protein Isoforms;Research;Technology;Tissues;transcriptome;transcriptome sequencing;usability;Work

PROJECT_TITLE: Realizing the potential of long-read sequencing technology

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Hematology;Rare Diseases;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Los Angeles

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Narrative During a human’s lifetime, organs modulate their functions and forms in response to changing physiological needs and external stimuli to reach their best possible performance levels. The epigenetic mechanism responsible for this adaptation is unknown. We use the avian integument model to study this process.

PI_NAMEs: CHUONG, CHENG-MING  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TITLE: Multi-scale modulation of organ adaptation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-S (55)]


PHR: The proposed research is relevant to public health because it will contribute a new and universal method to enhance the biological production of natural-product derived medicines, which include key antibiotics, anti- cancer, and pain medication drugs. Once such a method is developed, these medicinal compounds, which cannot currently be obtained in a scalable and reliable way, can potentially become more widely available. Therefore, the proposed research is relevant to NIH's mission in reducing illness and disability.

PI_NAMEs: LI, HAN  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TITLE: Expanding the Metabolic Currencies of Life


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: RIVERSIDE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: Project Narrative The 5' phosphate of nascent cellular and viral RNAs is stringently regulated to modulate gene expression and virus infection. How these RNAs are regulated by mechanisms other than capping reactions remains as a key knowledge gap. The PI will examine the roles and mechanisms of a novel and conserved RNA polyphosphatase family in regulating cellular mRNAs and lincRNAs, and the roles of two other modifications in regulating piRNAs and viral RNAs, likely generating new gene regulation tools for biomedical research and disease treatments.

PI_NAMEs: GU, WEIFENG  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Area;Binding;Biological;Biomedical Research;Caenorhabditis elegans;Cell Nucleus;Cells;chromatin modification;Cytoplasm;Developmental Process;Disease;DNA biosynthesis;Eukaryotic Cell;Event;Family;Gene Expression;Gene Expression Regulation;Genetic Transcription;Germ Cells;Health;High-Throughput Nucleotide Sequencing;Human;human disease;Influenza A virus;Innate Immune Response;innovation;inorganic phosphate;Knowledge;Malignant Neoplasms;Mediating;Messenger RNA;Modification;Neurodegenerative Disorders;Neurons;next generation;novel;Nuclear RNA;Pathway interactions;piRNA;Play;posttranscriptional;Process;Proteins;Reaction;Research;Research Personnel;Ribosomal RNA;RNA;RNA Splicing;RNA Stability;Role;sensor;Small Nuclear RNA;Small RNA;tool;Transfer RNA;tripolyphosphate;U1 small nuclear RNA;U2 small nuclear RNA;viral detection;viral RNA;Virus;Virus Diseases

PROJECT_TITLE: Investigating the roles of nuclear RNA modifications in gene regulation


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: BERKELEY

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative The objective of this research is to develop and apply new computational methods for analyzing human genomic data. We will use these methods in multiple applications to enhance our understanding of how processes such as mutation, recombination, natural selection, and human migration has shaped the landscape of human genetic variability and disease susceptibility.

PI_NAMEs: NIELSEN, RASMUS  (contact)

PROJECT_TERMS: Affect;Bayesian Method;Cell Differentiation process;Cell model;Cells;computational suite;computerized tools;Computing Methodologies;Data;Development;Disease susceptibility;DNA;DNA sequencing;Europe;Evolution;flexibility;Generations;genetic information;Genetic Recombination;Genome;genome sequencing;genomic data;genomic variation;Genomics;Geographic Locations;Graph;heteroplasmy;Historical Demography;Human;Human Genetics;human migration;improved;Individual;Intervention;Joints;Maps;Markov chain Monte Carlo methodology;Medical;Methods;migration;Mitochondria;Modeling;Modernization;Mutation;Natural Selections;open source;Pattern;Phenotype;Population Genetics;Process;programs;Research;Research Personnel;Sampling;scale up;Shapes;single-cell RNA sequencing;spatiotemporal;Structure;Testing;Trees;user-friendly;Variant;Visit;whole genome

PROJECT_TITLE: Inference and application of graphs for genomic data


ADMINISTERING_IC: DP

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Type 2 diabetes (T2D) is a leading cause of preventable death and disability in the U.S., and more than 1.5 million more Americans develop T2D every year. More than half of those new cases could be prevented or delayed if high risk adults were offered resource-intensive lifestyle intervention programs while they have prediabetes. Our proposed center will develop a collaborative network of “sentinel” health systems, National Diabetes Prevention Program and Medicare Diabetes Prevention Program delivery organizations, and experts in natural experimental research using “real world” data. We will collect and harmonize this data and, using rigorous natural experiment designs to identify individual, social, and structural barriers to, and facilitators of, participation in and completion of NDPP and MDPP services and 2) evaluate the long-term effectiveness and cost-effectiveness of structured lifestyle interventions, as implemented under the NDPP and MDPP.

PI_NAMEs: ACKERMANN, RONALD T. (contact)

PROJECT_TITLE: DP22-001 A Sentinel Network for Evaluation of the Reach, Implementation, Effectiveness, and Costs of Evidence-Based Lifestyle Interventions to Prevent Type 2 Diabetes in U.S. Adults


ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

ORG_STATE: NC

PHR: PROJECT NARRATIVE  The Centers for Disease Control and Prevention (CDC) aims to create a research network of study sites to assess barriers and facilitators for enrollment and sustained participation in the National Diabetes Prevention Program (DPP) and Medicare DPP and to determine the long-term effectiveness and cost-effectiveness of the programs. The Coordinating Center (CC) will facilitate scientific collaboration to achieve the program objectives by providing scientific and statistical expertise and logistical and data management support. Specifically, the CC will contribute to the design, development, and management of centralized protocols with common core data elements and will establish study operations to efficiently monitor studies and to collect, manage, analyze, report, and disseminate the research findings.

PI_NAMEs: JACOBS, SARA RUBIN (contact)

PROJECT_TITLE: DP22-001 Coordinating Center (CC) for Determining the Long-Term Effectiveness of Real World structured lifestyle interventions in preventing type 2 diabetes


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE We propose to establish a cohort of overweight and obese adults meeting National Diabetes Prevention Program eligibility criteria who either enrolled (N=5516) or did not enroll (N=7355) in the National DPP between 2013 and 2019. We will reassess their health status 5 years after they enrolled in the DPP or entered the longitudinal cohort to: 1) identify individual and system-level barriers to and facilitators of enrollment in and completion of the DPP and 2) evaluate the long-term effectiveness and cost-effectiveness of the DPP in: a) delaying the onset of type 2 diabetes; b) improving cardiovascular disease risk factors including body mass index, hemoglobin A1c (HbA1c), blood pressure, lipid levels, and smoking status; c) reducing the incidence of cardiovascular disease including transient ischemic attack, stroke, myocardial infarction, revascularization procedures, and hospitalization for heart failure; d) improving health-related quality-of-life; and e) reducing health care service utilization and cost.

PI_NAMEs: HERMAN, WILLIAM H (contact)

PROJECT_TITLE: DP22-001 Real-world effectiveness of structured lifestyle interventions in preventing type 2 diabetes


ADMINISTERING_IC: PS

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL CENTER FOR HIV, VIRAL HEPATITIS, STD AND TB PREVENTION

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PI_NAMEs: HIGHTOW-WEIDMAN, LISA B (contact)

PROJECT_TITLE: RFA-PS-21-003: PrEP Choice: Increasing the Use of HIV Pre-exposure Prophylaxis in an Era of Choices


PHR: Project Narrative This project will examine the long-term effectiveness and cost effectiveness of DPP, as well as barriers and facilitators to DPP participation, among adults at-risk for developing type 2 diabetes in a Multi-campus University System and a Three-state Regional Health Network.

PI_NAMEs: DURU, OBIDIUGWU KENRIK;MOIN, TANNAZ  (contact)

PROJECT_TITLE: DP22-001 Evaluating Real-world Diabetes Prevention Programs in a Multi-campus University System and a Three-state Regional Health Network


NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: CHEMISTRY

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Project Narrative The goal of the proposed research is to elucidate the role olfactory receptors (ORs) expressed outside the olfactory tissue play in human health and asses their potential as therapeutic targets. Olfactory receptors are a subtype of transmembrane proteins called G-protein coupled receptors (GPCRs), which are an important therapeutic target. As part of the proposed research, we also work towards understanding how GPCR signaling pathways talk to one another and the consequences of this crosstalk to human health, with the goal of enabling the development of new therapies.

PI_NAMEs: PERALTA-YAHYA, PAMELA  (contact)

PROJECT_TERMS: Acceleration;Algorithms;Animal Behavior;Architecture;Biological Process;cell motility;Cell Physiology;Cell Surface Proteins;Cell Surface Receptors;Cells;Chemicals;Chemotaxis;combinatorial;Development;Engineering;Family;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Genetic;Goals;GPR3 gene;GTP-Binding Proteins;Health;Human;Immunity;Integral Membrane Protein;Interphase Cell;Knowledge;Ligands;machine learning model;Mammalian Cell;muscle regeneration;next generation;novel therapeutics;olfactory receptor;Orphan;Outcome;overexpression;Pathway interactions;Phenotype;Play;Process;Receptor Activation;Research;Role;sensor;sensor technology;side effect;Signal Pathway;Signal Transduction;sperm cell;Therapeutic;therapeutic target;Tissues;training data;treatment response;Work

PROJECT_TITLE: Olfactory receptor-based sensors for biomedical applications

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: DURHAM

ORG_DEPT: PHARMACOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE (RELEVANCE STATEMENT) – OVERALL The Duke Cancer Institute, which has authority and responsibility for all cancer-related activities at Duke University and in the Duke University Health System, provides support and promotes collaborations between faculty and staff involved in cancer research, education, and patient care. This Cancer Center Support Grant facilitates oversight and integration of all cancer-related research activities, from basic research to translational studies to clinical and population investigation to community outreach to global cancer. Building upon an extensive strategic planning process, priority activities to maximize local, regional, and national impact have been identified.

PI_NAMEs: KASTAN, MICHAEL B (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Achievement;anti-cancer research;Arts;authority;Award;Basic Science;Businesses;Cancer Burden;cancer care;Cancer Center Support Grant;cancer genomics;Cancer Patient;Cancer Science;career development;Caring;Catchment Area;Clinical;clinical care;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;community engagement;Community Health;Community Outreach;Complex;cost;design;Development;Direct Costs;Discipline of Nursing;Duke Comprehensive Cancer Center;Education;Engineering;Enrollment;Environment;Faculty;Faculty Recruitment;Fellowship;Funding;Future;Goals;Grant;Health;health disparity;Health system;Infrastructure;innovation;Interdisciplinary Study;Intervention;Investigation;Investments;Laboratories;Leadership;Link;Malignant Neoplasms;medical schools;Medicine;member;Mission;multidisciplinary;new technology;next generation;novel;Oncology;outpatient facility;Paper;Patient Care;Patients;Peer Review;Pilot Projects;Population;population based;Population Research;Population Sciences;Process;programs;Public Policy;Publishing;Recommendation;recruit;Research;Research Activity;Research Infrastructure;Research Personnel;Research Technics;Resource Allocation;Resource Sharing;Schools;Science;Scientist;Series;Signal Transduction;Strategic Planning;Structure;Testing;Therapeutic;therapeutic development;therapeutic evaluation;Time;Training;Training and Education;training opportunity;Translational Research;translational study;Translations;Universities;University Hospitals;Work

PROJECT_TITLE: Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: KHARASCH, KAREN  (contact)

PROJECT_TERMS: Academic support;Ambulatory Care Facilities;anti-cancer research;Appropriateness Review;Area;Businesses;Cancer Center Support Grant;career development;Clinical;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;community engagement;Community Outreach;dashboard;Dedications;Development;Disease;Education;Educational Activities;Ensure;experience;Faculty;Feedback;Fellowship;flexibility;Focus Groups;Funding;Geographic Locations;Goals;Grant;Health;health equity;Hospitals;Human Resources;improved;Informatics;Infrastructure;Institution;Investments;Leadership;lectures;Malignant Neoplasms;medical schools;Medicine;member;Mission;Monitor;operation;organizational structure;Outcome;outreach;Performance;Philanthropic Fund;Play;Positioning Attribute;Problem Solving;Process;process repeatability;programs;Protocols documentation;quality assurance;Recommendation;recruit;Research;Research Activity;Research Contracts;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Role;Safety;Schools;Services;Site;Source;Strategic Planning;success;sustainable resource;Time;Training;Training and Education;Training Support;Vision;working group

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Cancer;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases

PI_NAMEs: BLOBE, GERARD C (contact)

PROJECT_TERMS: Accreditation;African American student;anti-cancer research;Cancer Biology;Cancer Center Support Grant;cancer health disparity;Cancer Patient;career;career development;Cellular biology;clinical care;Clinical Research;Dedications;Development;Diverse Workforce;Education;education research;Educational Curriculum;Effectiveness;Ensure;Environment;experience;Faculty;Fellowship Program;Foundations;Funding;Goals;graduate school;graduate student;Grant;Gynecologic Oncology;health equity;Health Professional;Health system;High School Student;Historically Black Colleges and Universities;Internal Medicine;Investments;Laboratory Research;Malignant Neoplasms;matriculation;Medical;Medical Oncology;medical schools;Medical Students;member;Mentors;Molecular;Molecular Biology;neuro-oncology;next generation;North Carolina;Pediatric Oncology;Pediatric Surgical Procedures;Pediatrics;Physicians;Physicians' Offices;Postdoctoral Fellow;programs;Qualifying;Radiation Oncology;Radiosurgery;Reporting;Research;Research Institute;Research Personnel;Residencies;Resource Development;Resources;Role;Scientist;Seasons;Societies;Solid;Solid Neoplasm;stem cell biology;Surgical Oncology;TNFSF15 gene;Training;Training and Education;Training Programs;tumor;Underrepresented Minority;Universities

PROJECT_TITLE: CRCE and Related Activities Core


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer

PI_NAMEs: FISH, LAURA  (contact)

PROJECT_TERMS: Accounting;Address;Administrator;anti-cancer research;Atlases;Basic Science;Behavioral;behavioral health;Behavioral Research;Behavioral Sciences;Businesses;Cancer Center;Cancer Center Support Grant;Client;Clinical Sciences;Code;Collaborations;Communication;Communities;Comprehension;Consult;Consultations;Data Analyses;Data Collection;design;Detection;Development;Education;Educational Materials;Ensure;Epidemiologic Methods;epidemiology study;evidence base;experience;Faculty;Family;Family member;Focus Groups;Fostering;Funding;Future;Goals;Growth;Health;health communication;Health system;improved;information processing;Intervention;Interview;Malignant Neoplasms;medical schools;member;Methods;Needs Assessment;Palliative Care;patient oriented;Patients;Population Sciences;Prevention;programs;Publications;Qualitative Methods;Qualitative Research;Readability;Recommendation;recruit;Research;Research Institute;Research Methodology;Research Personnel;Resource Sharing;Resources;Science;Service provision;Services;Standardization;Structure;Surveys;survivorship;Testing;tool;Translating

PROJECT_TITLE: Behavioral Health & Survey Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: OWZAR, KOUROS  (contact)

PROJECT_TERMS: Accounting;Address;Adherence;admixture mapping;analysis pipeline;Applications Grants;biobank;Bioinformatics;bioinformatics infrastructure;Bioinformatics Shared Resource;Biometry;Biostatistics Shared Resource;Cancer Center;Cancer Center Support Grant;cancer genomics;cell free DNA;Charge;ChIP-seq;Clinical;Clinical Research;Cloud Computing;Cloud Service;Collaborations;Complex;Computational Biology;computerized tools;Contracts;cost;cost effectiveness;cost efficient;Data;data integration;data management;Data Provenance;data registry;Data Set;Data Storage and Retrieval;database of Genotypes and Phenotypes;Databases;design;Development;diverse data;DNA sequencing;empowerment;Faculty;functional genomics;Funding;Genetic;genome sequencing;genome wide association study;genomic data;Genomics;Germ Lines;Grant;Health;High-Throughput Nucleotide Sequencing;Image;Informatics;Information Systems;Infrastructure;Institute of Medicine (U.S.);Journals;large datasets;literate;Machine Learning;Malignant Neoplasms;Manuscripts;medical schools;member;Methodology;Methods;microbiome;Mission;Modeling;multidimensional data;open source;Pathology;Pediatric Oncology;Phenotype;Philosophy;programs;Publications;Publishing;Quality Control;Reproducibility;Research;Research Institute;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Running;Science;sequencing platform;Services;single cell analysis;single-cell RNA sequencing;sound;Source Code;Standardization;Statistical Data Interpretation;T cell receptor repertoire sequencing;The Cancer Genome Atlas;tool;trait;translational medicine;tumor;whole genome;Writing

PROJECT_TITLE: Bioinformatics Core


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: BALTIMORE

ORG_DEPT: GENETICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE Advances in human genetics and genomics continue at an astounding rate and increasingly they are being integrated into medical practice. The Johns Hopkins Predoctoral Training Program in Human Genetics (HG) aims to educate highly motivated and capable students with the knowledge and experimental tools that will enable them to answer important questions at the interface between genetics and medicine. Ultimately, our trainees will be the leaders in delivering the promise of genetics to human health.

PI_NAMEs: DOHENY, KIMBERLY F;MCCALLION, ANDREW S (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Genetics

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Detecting signatures of selection from molecular data is a central problem in population genetics and phylodynamics. The proposed research will develop novel models of selection and statistical tests providing insights for understanding disease and the effect of genetic variants. The proposed research is relevant to NIH’s mission pertaining the developing of fundamental knowledge that will enhance health.

PI_NAMEs: PALACIOS, JULIA  (contact)

PROJECT_TERMS: Bayesian Analysis;Biological;Combinatorial Optimization;Data;Demography;Disease;Environment;Evolution;Genealogy;genetic variant;Genetic Variation;Genomic Segment;Health;Individual;insight;Knowledge;Laboratories;Laboratory Research;Mathematics;Methods;Mission;Modeling;Molecular;Mutation;novel;novel strategies;Organism;pathogen;Pattern;Phylogenetic Analysis;Population;Population Genetics;Process;programs;Property;Research;Shapes;Source;Testing;theories;tool;United States National Institutes of Health;Variant

PROJECT_TITLE: Novel Coalescent Approaches for Studying Evolutionary Processes


PI_NAMEs: MCCALL, SHANNON JONES (contact)

PROJECT_TERMS: Accreditation;African American;Algorithmic Analysis;Algorithmic Software;American;Animal Model;Archives;Benign;biobank;Biological;Biological Assay;Biopsy;Bladder;Blood;Breast;Budgets;Cancer Biology;cancer cell;Cancer Center Support Grant;Cell Line;Cells;Characteristics;Clinical;Clinical Research;clinical trial enrollment;Clinical Trials;cohort;college;Colorectal;community engagement;Consent;Cryopreservation;Data;Databases;Dedications;Disease;DNA;Enrollment;Ensure;ethical, legal, and social implication;Event;Fostering;Future;Generations;Genomics;Goals;health equity;Health Service Area;Health system;Histology;Image Analysis;Immunohistochemistry;improved;In Situ Hybridization;Infrastructure;Institution;Instruction;International;Journals;Kidney;Laboratories;laser capture microdissection;Leadership;Libraries;Link;Liquid substance;Lung;Malignant - descriptor;Malignant Neoplasms;Medicine;member;microbiome;Microdissection;Minority;Minority Participation;Molecular;Monitor;Nature;Operative Surgical Procedures;Ovarian;Paraffin;Paraffin Tissue;Participant;Pathologist;Pathology;patient derived xenograft model;patient oriented;Patients;Phase;Population;precision oncology;Primary Cell Cultures;programs;Prostate;Proteomics;Protocols documentation;Publications;quantitative imaging;Reporting;repository;Research;Research Institute;Research Personnel;Research Support;Resource Sharing;response;Retrieval;Retrospective Studies;RNA;sample collection;Sampling;Schedule;Services;Shipping;Site;Societies;Solid;Source;standard of care;Technology;The Cancer Genome Atlas;tissue archive;Tissue Banks;Tissue Microarray;tissue processing;Tissue Sample;Tissues;Translational Research;tumor;underserved minority;Universities;Vertebral column;Veterinary Pathology;Visualization;waiver;whole slide imaging;Work

PROJECT_TITLE: BioRepository and Precision Pathology Center


PI_NAMEs: NIEDZWIECKI, DONNA  (contact)

PROJECT_TERMS: Accounting;Animals;anti-cancer research;Applications Grants;Area;Award;base;Basic Science;Behavioral;Bioinformatics Shared Resource;Biometry;Biostatistics Core;Biostatistics Shared Resource;Cancer Biology;cancer care;Cancer Center Support Grant;cancer initiation;Cancer Science;Cell Line;Chemistry;Clinical;clinical development;Clinical Protocols;Clinical Research;Clinical Sciences;Clinical Trials;Clinical Trials Design;Consultations;Data;data cleaning;Data Linkages;data management;Databases;design;Development;Disease;Environment;Epidemiology;Equilibrium;Faculty;Family;Funding;Grant;Health Services Research;Immunology;Information Systems;Journals;knowledgebase;Leadership;Letters;Malignant Neoplasms;Manuscripts;Medidata;meetings;member;Mentors;Methods;Mission;Modeling;Molecular;Monitor;Multicenter Studies;Neoplasm Metastasis;next generation;Observational Study;Patients;Persons;Population;Population Sciences;prevent;programs;prospective;Protocols documentation;Publications;Reporting;Research;Research Activity;research and development;Research Design;Research Institute;Research Personnel;Research Priority;Research Training;Resource Sharing;Resources;Risk Factors;Science;screening;Services;Site;Specimen;System;Testing;Tissues;tool;Training;Training Programs;Translational Research;Work;working group;Writing

PROJECT_TITLE: Biostatistics Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Coronaviruses;Genetics;Heart Disease;Rare Diseases;Regenerative Medicine

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE Dr. Gallagher’s laboratory has provided seminal studies related to epigenetic regulation of immune cell plasticity in the setting of tissue injury in the context of both normal and pathologic states (aneurysm formation, tissue regeneration, sepsis, COVID) for over 10 years. This EIA award will support on-going studies 1) to understand how epigenetic regulation of macrophage plasticity alters abdominal aortic aneurysm development; 2) to understand how JAK/STAT signaling in macrophages regulates chromatin modifying enzymes (CMEs) downstream in a variety of cardiovascular diseases; 3) to understand interactions between structural cells (fibroblasts, smooth muscle cells, keratinocytes) and macrophages in the setting of cardiovascular disease; and 4) to examine the role of epigenetic regulation of macrophages on peripheral atherosclerotic disease.

PI_NAMEs: GALLAGHER, KATHERINE ANN (contact)

PROGRAM_OFFICER_NAME: GALIS, ZORINA S

PROJECT_TERMS: Abdominal Aortic Aneurysm;Aneurysm;Animal Model;Animals;Area;Atherosclerosis;Award;Biological Markers;Cardiovascular Diseases;Cells;chemokine;Chromatin;Chronic;Clinic;COVID-19;Data;Development;Enzymes;Epigenetic Process;epigenetic regulation;Etiology;Fibroblasts;Goals;Grant;Human;immunoregulation;Inflammation;injured;Innate Immune Response;interest;keratinocyte;Laboratories;Macrophage;metabolomics;monocyte;Myeloid Cells;novel;novel marker;novel therapeutics;Pathogenesis;Pathologic;Pathway interactions;Patients;Peripheral;Phenotype;Process;programs;Prostaglandins;Publishing;Recovery;recruit;Regulation;Research;Research Personnel;Role;SARS-CoV-2 infection;Seminal;Sepsis;Shapes;Signal Pathway;Signal Transduction;Smooth Muscle Myocytes;Therapeutic;therapeutic target;tissue injury;tissue regeneration;tissue repair;Tissues;validation studies;Vascular Diseases;Work

PROJECT_TITLE: The epigenetic regulation of inflammation in tissue repair and vascular disease


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Boston

ORG_DEPT: MISCELLANEOUS

ORG_NAME: TUFTS UNIVERSITY MEDFORD

ORG_STATE: MA

PHR: PROJECT NARRATIVE There are widespread racial disparities in the risk of cognitive impairment and dementia, and healthcare utilization among older adults with cognitive impairment. We propose to move beyond individual-level risk factors of cognitive impairment to examine structural racism as an underlying cause of these racial disparities. Findings will guide multi-level interventions to prevent and delay cognitive impairment, as well as policy-makers' decisions regarding possible sectors (e.g., housing, education, labor/economics) in which to intervene to address racial disparities in cognitive impairment.

PI_NAMEs: ALI, TALHA  (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: 3-Dimensional;Accounting;Address;Adopted;Adverse effects;Affect;Age;Age Years;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;American;Area;Belief;Black American;Black Populations;Black race;black/white disparity;Buffers;cardiovascular health;caucasian American;Cause of Death;Censuses;Chronic;Clinical Trials;Cognitive;cognitive function;County;Data;Dementia;dementia care;dementia risk;design;Diagnosis;Disease Management;Disparity;Economics;Education;Educational Status;Environment;Environmental Risk Factor;Equity;experience;Exposure to;Fostering;Frequencies;functional decline;functional disability;Future;Goals;Health;Health and Retirement Study;health assessment;health care availability;health care service utilization;Health Care Visit;health disparity;health inequalities;Health Services Research;Healthcare;Home;Home Care Services;Hospitalization;Housing;Hypertension;Impaired cognition;Impairment;improved;Incidence;Individual;insight;Institution;interest;Intervention;late life;Length of Stay;Life Cycle Stages;lifestyle factors;Link;Measures;Medicaid;Medicare claim;Mentors;Methods;Modeling;Modification;Neurobiology;neuropsychiatric symptom;Obesity;Observational Study;older adult;Outcome;Ownership;Pathogenesis;Pensions;Persons;physical conditioning;Policies;Policy Analysis;Policy Maker;pollutant;Population Research;prevent;protective factors;psychosocial;Public Health Schools;Quality of life;Race;racial disparity;racism;Reduce health disparities;Research;Research Priority;resilience;Resources;Risk;Risk Factors;Skilled Nursing Facilities;Social Justice;Social Network;Social support;socioeconomic disparity;Source;Statistical Data Interpretation;statistics;Stress;stressor;Structural Racism;System;toxicant;Training;United States;Work

PROJECT_TITLE: Impact of Structural Racism on Racial Disparities in Cognitive Impairment

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Cancer;Immunotherapy

PI_NAMEs: WEINHOLD, KENT J. (contact)

PROJECT_TERMS: Accounting;Address;arm;Autoimmunity;Bioinformatics;Biological Assay;Biological Markers;Cancer Center Support Grant;cancer therapy;Caring;Chemotherapy and/or radiation;Clinical;Clinical Trials;Collaborations;Data;data acquisition;Data Analyses;Data Analytics;Data Collection;Data Reporting;experience;experimental study;Extramural Activities;Flow Cytometry;Foundations;high dimensionality;Human;Immune;immune checkpoint blockade;Immune response;Immunologics;Immunology;Immunooncology;Immunotherapy;immunotherapy trials;improved;innovation;interest;Intervention;Journals;Malignant Neoplasms;Medical;member;Methodology;Methods;Mission;multidimensional data;Neuromuscular Diseases;novel;Outcome;patient population;Patients;Performance;pharmacodynamic biomarker;pharmacologic;Phase I/II Clinical Trial;Pilot Projects;predict clinical outcome;predictive marker;predictive signature;programs;Publications;Rare Diseases;Recording of previous events;Research;Research Design;Research Infrastructure;Research Personnel;Resource Sharing;Resources;Science;Services;Specimen;standard of care;Standardization;Technology;technology platform;Testing;Time;Translating;translational cancer research;Translational Research;Transplantation;Universities;Virus Diseases;Writing

PROJECT_TITLE: Duke Immune Profiling Core


PI_NAMEs: KRANGEL, MICHAEL S (contact)

PROJECT_TERMS: anti-cancer research;assay development;Biological Assay;Books;Calendar;Cancer Center Support Grant;cell analyzer;Cell Cycle;Cell Death;Cell Physiology;cell preparation;Cell Separation;Cells;Charge;Client;Clinical;Color;Computer software;Consultations;cost;cost effective;cytokine;Cytometry;data acquisition;Data Analyses;data handling;Development;discount;Equipment;experience;experimental study;Feedback;Fees;Flow Cytometry;Flow Cytometry Shared Resource;Fluorochrome;Goals;Image;Individual;Journals;Laboratories;laser cell sorter;Lasers;Libraries;Malignant Neoplasms;meetings;member;Membrane Proteins;Mission;Nature;Outcome;Population;Postdoctoral Fellow;Production;programs;Protocols documentation;Publications;Recommendation;Reporter;Research;Research Institute;Research Personnel;Research Project Grants;Reservations;Resource Sharing;Resources;Running;Schedule;Services;Signal Transduction;Sorting;Students;Technology;technology/technique;Time;Training;Work

PROJECT_TITLE: Flow Cytometry Core


PI_NAMEs: KIM, SO YOUNG  (contact)

PROJECT_TERMS: Accounting;Antineoplastic Agents;Area;Biochemical;Biological Assay;Cancer Center Support Grant;Cells;cellular engineering;chemical genetics;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Communities;Computers and Advanced Instrumentation;Consultations;cost effective;CRISPR/Cas technology;Custom;Dedications;design;Development;drug discovery;Experimental Models;experimental study;functional genomics;gain of function;Generations;Genes;Genetic;genetic manipulation;Genetic Screening;Genome engineering;genome-wide;Genomic Library;Genomics Shared Resource;Goals;high throughput analysis;high throughput screening;Human Genome;human stem cells;imaging system;improved;Individual;Infrastructure;instrumentation;interest;Investments;Journals;knock-down;Knock-in;Knock-out;Libraries;loss of function;Malignant Neoplasms;Mediating;member;Methodology;Modeling;Modification;mouse genome;multimodality;Mus;new technology;novel;novel therapeutics;Oncogenes;Open Reading Frames;overexpression;Pharmaceutical Preparations;physiologic model;Pilot Projects;programs;Publications;Reader;Reagent;Research;Research Institute;Research Personnel;Resource Sharing;Resources;RNA Interference;screening;Services;small hairpin RNA;Study models;Techniques;Technology;technology platform;therapeutic target;tool;Translating;Translational Research;uptake;user-friendly;Validation

PROJECT_TITLE: Functional Genomic Core


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

PHR: Project Narrative Existing targeted cancer therapies rely on inhibiting or degrading cancer drivers, leading to therapy resistance and subsequent disease progression. While therapeutic approaches that leverage chemically induced proximity have shown promise in overcoming mutational escape, they have largely been limited to degradation approaches, with similar resistance risks as direct inhibitors via epigenetic/transcriptional feedback. In this proposal, I aim to hijack the estrogen receptor by chemically induced proximity to transactivate a pro-apoptotic transcriptional program in breast cancers, to develop and demonstrate a novel targeted gain-of-function cancer therapeutic paradigm.

PI_NAMEs: KIM, SAMUEL H (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Address;Apoptosis;Apoptotic;BCL1 Oncogene;Binding;Bioinformatics;Biological Assay;Biology;Breast Cancer Cell;Breast Cancer cell line;Bypass;Cancer Biology;cancer cell;cancer therapy;cancer type;candidate identification;candidate validation;carcinogenesis;CASP3 gene;Cell Death;Cell Death Induction;Cell Survival;Cells;Chemicals;ChIP-seq;Consensus;Development;Disease Progression;Doxycycline;efficacy evaluation;Enhancers;Epigenetic Process;Equilibrium;Estrogen receptor positive;Estrogen Receptors;experimental study;Family member;Feedback;gain of function;Gene Expression Regulation;Genetic Transcription;genome-wide;Goals;Homeostasis;Individual;Induction of Apoptosis;Informatics;inhibitor;Knowledge;Lead;Libraries;Ligands;Literature;loss of function;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;MCF7 cell;Measures;Mutation;novel;novel therapeutic intervention;novel therapeutics;Oncogenes;overexpression;Pathway interactions;Patients;personalized medicine;Physicians;programs;promoter;Proteins;recruit;resazurin;Research Personnel;Resistance;resistance mechanism;resistance mutation;Risk;Scientist;Sirolimus;skills;Specificity;T47D;Tacrolimus Binding Proteins;targeted cancer therapy;targeted treatment;Testing;Therapeutic;Therapeutic Effect;therapy resistant;Time;tool;Training;Trans-Activators;Transactivation;Transcript;Transcription Coactivator;transcription factor;transcriptome sequencing;transcriptomics;Translating;Up-Regulation

PROJECT_TITLE: Hijacking cancer driver to activate cell death by chemically induced proximity


NIH_SPENDING_CATS: Cancer;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Accounting;Agreement;anti-cancer research;Bioinformatics Shared Resource;Biomedical Research;Biometry;Cancer Center Support Grant;Certification;Charge;Clinical;Clinical Research;Collaborations;Communication;Complex;Computer software;Computer Systems;Consult;Consultations;Cost Savings;Custom;Data;data centers;Data Coordinating Center;Data Security;Database Management Systems;Databases;design,build,test;Development;Documentation;electronic data;electronic data capture system;Ensure;Environment;Equipment and supply inventories;experience;Foundations;Funding;Goals;Health;Health system;Health Technology;Human Resources;improved;Information Systems;Information Technology;Infrastructure;Institution;Instructional Technology;Internet;Journals;Laboratories;Life Cycle Stages;Maintenance;Malignant Neoplasms;member;Methodology;Methods;migration;Modeling;Monitor;Procedures;Process;programs;Protocols documentation;Publications;recruit;Research;Research Personnel;Resource Informatics;Resource Sharing;Resources;response;Role;Security;Services;Site;skills;software infrastructure;Standardization;System;Systems Development;Technology;Training;Universities;website development

PROJECT_TITLE: Information Systems Core


ADMINISTERING_IC: HG

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Public Health Relevance. The personally identifying nature of the genomic data create risks of discrimination and stigmatization. We will develop and implement numerous computer-based methods that ensure genomic data is fully protected and the privacy of the participants are intact so that while an untrusted person, such as a genetic testing company, is analyzing data, they cannot directly gain access to an individual personal genetic information. The developed methods can improve public health by enabling the safe usage of the genetic information of patients while the we analyze data, assess risks, and diagnose diseases using genetic data.

PI_NAMEs: HARMANCI, ARIF OZGUN (contact)

PROGRAM_OFFICER_NAME: WELLINGTON, CHRISTOPHER

PROJECT_TERMS: All of Us Research Program;Authorization documentation;Awareness;Benchmarking;biobank;California;causal variant;cloud based;cloud platform;Cloud Service;Collaborations;Communication;Communities;Computing Methodologies;computing resources;convolutional neural network;cost;Curiosities;Custom;Data;Data Analyses;data imputation;Data Security;data sharing;Databases;design;Development;Discrimination;disease diagnosis;encryption;Ensure;Ethics;Family;flexibility;Florida;Genealogy;Genetic;genetic discrimination;genetic information;genetic testing;Genome;genome sequencing;genome wide association study;genome-wide;genomic data;Genomics;Genotype;high dimensionality;Hospitals;Hybrids;improved;in silico;Incentives;Indigenous;Individual;innovation;Laws;Learning;Linkage Disequilibrium;Maps;Measures;method development;Methods;Michigan;Modeling;Native-Born;Nature;novel;Outsourced Services;Outsourcing;Participant;Patients;Pattern;Performance;Personal Genetic Information;Persons;Phase;Policies;Population;population based;Population Genetics;Privacy;privacy preservation;privacy protection;Process;Public Health;public health relevance;Publishing;Quality Control;Recreation;Reproducibility;Research;Research Personnel;Rest;Risk;Risk Assessment;Sample Size;Secure;Security;Services;Statutes and Laws;Stigmatization;targeted sequencing;Techniques;Text;Time;Training;Trans-Omics for Precision Medicine;Tribal group;Underrepresented Populations;Variant

PROJECT_TITLE: Secure Outsourcing of Genotype Imputation for Privacy-aware Genomic Analysis (RO1HE21)

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


PI_NAMEs: WRAY, GREGORY A. (contact)

PROJECT_TERMS: Accounting;Advanced Malignant Neoplasm;Alternative Splicing;analysis pipeline;anti-cancer research;Binding Sites;Bioinformatics Shared Resource;Biological Assay;Cancer Center;Cancer Center Support Grant;cancer genomics;Cells;chromatin modification;Clinical;Clinical Trials;Collaborations;Computational Biology;Consultations;Core Facility;Correlative Study;cost;Data Analyses;data management;data quality;Databases;Development;DNA Methylation;Education;Educational workshop;Ensure;Epigenetic Process;equipment acquisition;Event;exome sequencing;experience;Experimental Designs;Fees;flexibility;Formalin;Genes;Genomics;Genomics Shared Resource;Goals;Grant;Guidelines;Immune system;improved;Information Dissemination;Infrastructure;innovative technologies;Institution;instrumentation;Journals;Knowledge;Learning;Malignant Neoplasms;Manuscripts;Maps;Measures;medical schools;member;Messenger RNA;microbial;microbiome;Molecular;nano-string;neoplastic cell;new technology;novel;Paraffin Embedding;Physiology;Preparation;Procedures;programs;Protocols documentation;Publications;Quality Control;Recovery;Research;research and development;Research Institute;Research Personnel;Resource Sharing;Resources;Reverse Transcriptase Polymerase Chain Reaction;sample collection;Sampling;Schedule;Services;single cell sequencing;Statistical Data Interpretation;Structure;success;Technology;technology platform;Time;tool;Training;Training and Education;transcription factor;transcriptome;transcriptomics;Update;Vendor;Work

PROJECT_TITLE: Integrated Cancer Genomics Core


NIH_SPENDING_CATS: Biotechnology;Genetics;Rare Diseases

ORG_NAME: GEORGIA STATE UNIVERSITY

PHR: PROJECT NARRATIVE The project will leverage new computational and structural systems biology approaches to provide unified knowledge of the assembly, function and regulation of key transcription and transcription-coupled DNA repair complexes. Unveiling the interplay of molecular-level mechanisms and disease mutations in these complexes will yield foundational understanding of severe genetic disorders associated with cancer, aging, and developmental defects – xeroderma pigmentosum, trichothiodystrophy, Cockayne syndrome and related diseases. Success of the project will thus have major impacts on understanding human disease etiology, opening new avenues to devise effective treatments.

PI_NAMEs: IVANOV, IVAYLO NIKOLAEV (contact)

PROJECT_TERMS: Aging;Biochemical Pathway;Cancer Etiology;cell growth;cell repository;Cells;Cockayne Syndrome;Complex;Computer Models;Coupled;Cryoelectron Microscopy;Data;Defect;Development;Disease;disease phenotype;DNA;DNA Polymerase I;DNA Polymerase II;DNA Polymerase III;DNA Repair;DNA-Directed RNA Polymerase;effective therapy;environmental change;Etiology;experimental group;Gene Expression;Gene Expression Regulation;gene function;gene repair;Genetic Code;Genetic Diseases;Genetic Transcription;Genomic DNA;Goals;Hereditary Disease;human disease;insight;Knowledge;Life;Malignant Neoplasms;Modeling;Molecular;Molecular Machines;Mutation;Nature;Process;promoter;Proteins;Regulation;Repair Complex;response;RNA;Science;Structure;success;Systems Biology;Transcription Factor TFIID;transcription factor TFIIH;Transcriptional Regulation;Trichothiodystrophy;Work;Xeroderma Pigmentosum

PROJECT_TITLE: Advanced Computational Modeling of Molecular Machines in Gene Regulation and DNA Repair

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer

PI_NAMEs: CAMERON, LISA A. (contact)

PROJECT_TERMS: Accounting;Advisory Committees;Cancer Center Support Grant;Cells;Charge;Collection;Confocal Microscopy;Consult;Consultations;data acquisition;Dedications;Doctor of Philosophy;Education;Environment;Equipment;experience;Experimental Designs;Faculty;Fees;Fluorescence;fluorescence imaging;fluorescence microscope;Fluorescence Microscopy;Fluorescence Recovery After Photobleaching;Funding;Future;high standard;Hour;Human Resources;Image;Image Analysis;image processing;Immunofluorescence Immunologic;Incubated;instrument;intravital imaging;Journals;laser capture microdissection;Light;light microscopy;live cell imaging;Location;Malignant Neoplasms;Marketing;Medical center;medical schools;medical specialties;member;microscopic imaging;Microscopy;Mission;Modality;model organism;Modeling;multi-photon;Mus;nanosecond;new technology;novel strategies;operation;Optics;photoactivation;Photobleaching;Policies;Preparation;Productivity;programs;Protocols documentation;Publications;Recommendation;Research;Research Institute;Research Personnel;Research Project Grants;Reservations;Resource Sharing;Resources;Sampling;Scanning;Services;single molecule;Slide;software systems;Structure;Surveys;System;Technical Expertise;Techniques;Technology;Testing;Time;tissue/cell culture;Tissues;Training;ultra high resolution;Universities

PROJECT_TITLE: Light Microscopy Core


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PUBLIC HEALTH RELEVANCE:  A subset of T cells, follicular B helper T cells, is necessary to provide help for B lymphocytes in their production of antibodies and autoantibodies in normal and autoimmune responses, respectively. Much remains to be learned about the biology of the former, including the requirements for their maturation and function, and how to interrupt their collaboration with B cells as a potential therapy for autoimmune diseases such as systemic lupus erythematosus (SLE or lupus). The results of the proposed studies should help address these issues, and advance knowledge of how lupus develops in humans.

PI_NAMEs: CRAFT, JOSEPH EDGAR (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: Acute;acute infection;Address;Affinity;Antibody Formation;Autoantibodies;Autoimmune Diseases;Autoimmune Responses;autoreactive B cell;autoreactivity;B Cell Proliferation;B-Lymphocytes;Biological Models;Biology;Blood;Cell Maturation;Cell Survival;Cells;Chronic;Chronology;Collaborations;cytokine;design;Development;Disease;disease phenotype;Dissection;experimental study;Gene Expression Profile;Generations;genetic signature;Genetic Transcription;Genomics;Goals;Helper-Inducer T-Lymphocyte;Human;Immune;Immune response;Immunization;Immunoglobulins;inflammatory milieu;Interferon Type II;interleukin-21;Interruption;Kidney;Knowledge;Learning;Lupus;lupus prone mice;Maintenance;Mediating;Memory;Memory B-Lymphocyte;mouse model;Mus;Pathogenesis;pathogenic autoantibodies;Pathologic;Patients;Pattern;Phenotype;Physiological;Plasma Cells;Production;public health relevance;Regulation;response;risk variant;Role;secondary lymphoid organ;Signal Transduction;STAT4 gene;STAT4 protein;Structure of germinal center of lymph node;systemic autoimmunity;Systemic Lupus Erythematosus;T-Lymphocyte Subsets;Therapeutic;Therapeutic Intervention;tissue injury;tool;Transcriptional Regulation;Uncertainty

PROJECT_TITLE: Immune Responses in Lupus

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


PI_NAMEs: PALMER, GREGORY MATHEW (contact)

PROJECT_TERMS: Accounting;Animal Housing;Animals;base;Bioluminescence;bioluminescence imaging;Budgets;Calendar;Cancer Biology;Cancer Center Support Grant;cancer initiation;Cancer Model;Categories;Collaborations;cost;cost effective;Data Analyses;design;Development;Ensure;Equipment;Experimental Designs;Faculty;Financial Support;Fluorescence;fluorescence imaging;foot;Functional Imaging;Funding;Growth;Image;imaging capabilities;Imaging Device;Imaging technology;in vivo;in vivo optical imaging;intravital microscopy;Journals;Kinetics;Laboratories;Logistics;Maintenance;Malignant Neoplasms;medical schools;member;Microscope;Molecular Analysis;molecular imaging;Monitor;operation;Operative Surgical Procedures;optical imaging;Optics;outreach;programs;Publications;Research;Research Institute;Research Personnel;Resource Sharing;Resources;service utilization;Services;Site;Solid;Spectrum Analysis;System;Techniques;Technology;Therapeutic;tomography;Training;Transportation;Tumor Biology;Universities

PROJECT_TITLE: Optical Molecular Imaging Core


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: HIV/AIDS

ORG_DEPT: VETERINARY SCIENCES

PHR: PROJECT NARRATIVE Veterinarian scientists play crucial roles by performing biomedical research and by developing, characterizing, and using animal models to study human diseases, thereby enhancing rigor and reproducibility. Our training program offers an outstanding career development opportunity for veterinarians passionate about building careers in biomedical research and becoming innovators and leaders in their research fields. This proposal seeks renewal of support for our highly productive NIH-funded T32 program led by Joseph L. Mankowski, DVM, PhD, to train veterinarians in biomedical research at the Johns Hopkins University School of Medicine.

PI_NAMEs: MANKOWSKI, JOSEPH L (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TITLE: Training Veterinarians for Careers in Biomedical Research


PI_NAMEs: SPASOJEVIC, IVAN  (contact)

PROJECT_TERMS: Accountability;Accounting;Animal Experiments;Animals;Antineoplastic Agents;Area;assay development;Basic Cancer Research;Biological Markers;Biopsy;cancer biomarkers;Cancer Center Support Grant;Cancer Therapy Evaluation Program;Chemicals;chemotherapy;Clinical;Clinical Research;Complex;Consultations;design;Documentation;Dose;drug candidate;Drug Compounding;drug development;drug discovery;Drug Evaluation;Drug Formulations;Drug Kinetics;Education;efficacy study;Ensure;Equipment and supply inventories;Funding;Goals;Guidelines;IACUC;instrumentation;Investigational Drugs;Journals;Malignant Neoplasms;member;Metabolic;Modeling;novel therapeutics;Oncology;Outcome;Pharmaceutical Preparations;Pharmaceutical Services;pharmacodynamic model;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacy facility;Phase;Plasma;pre-clinical;pre-clinical research;preclinical study;Preparation;Procedures;Process;programs;Property;protocol development;Protocols documentation;Publications;Records;Regimen;Regulation;Reporting;Research Design;Research Institute;Research Personnel;research study;Resource Sharing;Resources;Route;sample collection;Services;small molecule;Sterility;Tissues;Translation Process;Validation;Viral Vector;Willow;Work;Writing

PROJECT_TITLE: Pharmacokinetics Core


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: MOSELEY, MARTIN ARTHUR (contact)

PROJECT_TERMS: Academy;Acetylation;acylcarnitine;Amino Acids;Amplifiers;Basic Science;Belief;Bile Acids;Biogenic Amines;Biological Assay;Biological Markers;biomarker discovery;Blood;Blood Platelets;Cancer Center Support Grant;Cell Line;Ceramides;Cholesterol;Cholesterol Esters;clinical practice;Clinical Research;Collaborations;Computational Biology;Computer software;Consultations;cost;cost effective;Custom;Data;Data Analyses;Data Files;data integrity;data management;data quality;data quality/integrity;data repository;design;Development;differential expression;Diglycerides;Dissociation;Doctor of Philosophy;Education;Eicosanoids;Electrons;Ensure;Equipment;experience;Experimental Designs;experimental study;falls;Fatty Acids;Fingerprint;Funding;Generations;Genomics;Guidelines;industry partner;innovation;Institution;instrument;instrumentation;Journals;Label;Laboratories;laboratory experiment;Lecithin;Leukocytes;Lipids;Liquid Chromatography;long chain fatty acid;Lysophosphatidylcholines;Malignant Neoplasms;Management Information Systems;mass spectrometer;Mass Spectrum Analysis;meetings;member;metabolomics;Methods;Monoclonal Antibodies;Online Systems;Output;Performance;Phosphorylation;Plasma;Post-Translational Protein Processing;Postdoctoral Fellow;Preparation;professor;programs;Protein Analysis;protein complex;protein crosslink;Protein Footprinting;protein purification;Proteomics;Proteomics Shared Resource;Protocols documentation;Publications;Reporting;repository;Research;Research Institute;Research Personnel;research study;Resolution;Resource Sharing;Resources;Sampling;Scientist;Secure;Serum;Services;Sphingomyelins;square foot;Statistical Data Interpretation;Synovial Fluid;System;Technology;Time;Tissues;Translations;Triglycerides;tumor;Ubiquitination;Urine;Vendor;Volatile Fatty Acids;Water;Work

PROJECT_TITLE: Proteomics & Metabolomics Core


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Genetics;Natural Products;Nutrition;Prevention

ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

PHR: PROJECT NARRATIVE:RELEVANCE TO PUBLIC HEALTH Cocoa products have become a widely consumed food, with growing demand and increasing interest in its anti-aging biology. While the popularity of cocoa consumption remains steady, enthusiasm has outpaced the scientific evidence in humans. Thus, we propose to leverage the large-scale ongoing national randomized clinical trial called COSMOS to evaluate the effect of cocoa supplementation on longitudinal change in biological aging including epigenetic aging and inflammation aging in relation to cardiovascular disease (CVD). Parallel assessments of the randomized multivitamin intervention on the same biological aging and CVD outcomes will be also performed, as multivitamins have remained the most common dietary supplement, taken by at least one-third of US adults. Thus, this study will not only provide valuable insights into the underlying molecular mechanisms for the two popular supplements (cocoa and multivitamin), but also holds great promise for targeting by nutritional interventions.

PI_NAMEs: DONG, YANBIN  (contact);SESSO, HOWARD D

PROGRAM_OFFICER_NAME: YARDEN, RONIT I

PROJECT_TERMS: accelerated epigenetic aging;Adult;age acceleration;age related;age-related disease;aged;Aging;Ancillary Study;Animal Model;anti aging;Anti-Inflammatory Agents;Biological Aging;Biology of Aging;Blood;C-reactive protein;Cardiovascular Diseases;cardiovascular disorder risk;Chocolate;Chronic;Cocoa Powder;cohort;Collection;Consumption;cost;cost effective;cytokine;Darkness;Dietary Intervention;dietary supplements;Disease Outcome;Disease susceptibility;DNA Methylation;Double-Blind Method;Effectiveness;Elderly;epicatechin;epigenetic aging;epigenetic clock;Epigenetic Process;Flavanol;follow-up;Food;food consumption;functional decline;Gene Expression;Health;Health Benefit;healthspan;healthy aging;Human;human old age (65+);In Vitro;indexing;Inflammaging;Inflammation;Inflammatory;insight;interest;Interleukin-1 beta;Interleukin-4;Interleukin-6;Intervention;life span;lifestyle intervention;Malignant Neoplasms;Measures;Mediating;men;Molecular;Morbidity - disease rate;mortality;mortality risk;Multivitamin;novel;Observational Study;Outcome;Outcome Study;Parents;Participant;Pathogenesis;Personal Satisfaction;Placebo Control;Placebos;Property;Public Health;public health relevance;Randomized;randomized, clinical trials;Randomized, Controlled Trials;recruit;Research;Resources;Risk Factors;Risk Reduction;Role;Serum;Severities;Supplementation;Testing;Time;TNF gene;Woman

PROJECT_TITLE: Effect of randomized cocoa supplementation on inflammaging and epigenetic aging

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

PI_NAMEs: NORTON, JOHN N. (contact)

PROJECT_TERMS: Advanced Malignant Neoplasm;Animal Barrier Facility;animal facility;Animal Housing;Animal Model;animal resource;Animals;anti-cancer research;biobank;biosecurity;Breeding;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cancer Model;cancer therapy;Cell Line;Censuses;Clustered Regularly Interspaced Short Palindromic Repeats;Consultations;cost;cost effective;Custom;Dedications;design;Development;Diagnosis;Diagnostic Services;Embryo;embryonic stem cell;Emerging Technologies;Engineering;Ensure;Environment;Equipment;gene editing technology;gene synthesis;Gene Targeting;gene-editing approach;Generations;Genes;Genetic Engineering;Genetic Models;genome editing;Genome engineering;Genomics;germ free condition;Goals;Hazardous Substances;Heart;Housing;Human;Human Resources;Immunocompromised Host;immunosuppressed;improved;Inbreeding;Individual;Investigation;Investments;Journals;Laboratory Animals;Location;Maintenance;Malignant Neoplasms;Mediating;medical schools;member;Modeling;Molecular Analysis;molecular imaging;Mus;New Agents;Nude Mice;operation;Optics;pathogen;Pathology;Plants;Procedures;Production;programs;protocol development;Publications;Reader;Reagent;Recombinant DNA;Research;research and development;Research Institute;Research Personnel;Research Training;Resource Sharing;Resources;Risk Reduction;Robotics;Rodent;Rodent Model;Services;square foot;Sterility;Students;Synthetic Genes;System;Techniques;Technology;Testing;Therapeutic;Training;Transgenic Organisms;Update;user-friendly;ventilation;Water;Work

PROJECT_TITLE: Rodent Cancer Models Core


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Services;Palliative Care;Prevention

PI_NAMEs: POLLAK, KATHRYN I (contact)

PROJECT_TERMS: Address;Advisory Committees;Affect;Aging;anti-cancer research;Area;Attention;Award;Behavior;behavioral health;Biological Markers;Cancer Burden;cancer care;Cancer Center Support Grant;Cancer Control;Cancer Control Research;Cancer Etiology;Cancer Family;cancer health disparity;Cancer Patient;cancer risk;Cancer Survivorship;care delivery;career development;Caregiver support;Caring;Catchment Area;Collaborations;Colorectal Cancer;Communicable Diseases;Communities;Continuity of Patient Care;Data Science;Death Rate;Decision Making;design;Diagnosis;disparity reduction;Education;education research;Educational Activities;eHealth;end of life;Enrollment;experience;Faculty;Family;Family member;Financial Hardship;Fostering;Funding;Future;graduate student;Grant;Growth;Guidelines;Harm Reduction;health equity;Health system;Historically Black Colleges and Universities;improved;Incidence;Individual;Infectious Agent;innovation;Intervention;Intervention Trial;Journals;K-Series Research Career Programs;Leadership;Link;Malignant Breast Neoplasm;Malignant Childhood Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;malignant stomach neoplasm;member;Mentors;Methodology;Methods;mHealth;Minority Groups;Molecular Epidemiology;new technology;North Carolina;novel;nutrition;Obesity;Oncology;Outcome;Pain management;Palliative Care;Paper;Participant;Patient-Focused Outcomes;Peer Review;Physical activity;Policies;Population Sciences;Postdoctoral Fellow;posters;Primary Care;Primary Prevention;Program Development;programs;Publishing;Research;Research Personnel;Resources;Risk;Risk Factors;risk prediction;Risk Reduction;Role;Schools;screening guidelines;Sexual Health;Spirituality;Standardization;Surveys;Survivors;survivorship;symptom management;symptomatic improvement;synergism;Teacher Professional Development;Tobacco;Training;Training Programs;Translating;treatment adherence;treatment trial;Universities;Vision;Work;working group

PROJECT_TITLE: CCPS Program


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Pain Research

ORG_CITY: NOVATO

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

PHR: Project Narrative The proposed research will provide critical insight into mechanisms by which neuropeptide signaling modulates neural circuits to influence behavior. As neuropeptides and their receptors are druggable targets and their dysregulation is implicated in medical conditions ranging from obesity to psychiatric disorders, mechanistic insight into their signaling is likely to have broad clinical relevance for human health. Understanding how neuropeptide signaling functionally rewires the brain has the potential to uncover novel therapeutic targets for the etiology and treatment of metabolic, sleep, and pain disorders as well as neuropsychiatric conditions characterized by behavioral dysfunction, including depression, autism, anxiety, addiction, and schizophrenia.

PI_NAMEs: GARRISON, JENNIFER L (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: addiction;Address;Affect;Anatomy;Animals;Anxiety;Arousal;autism spectrum disorder;Behavior;Behavior Control;behavior influence;Behavioral;Biochemical;Biological Models;Brain;cell type;Central Nervous System;clinically relevant;Communication;Disease;druggable target;Emotional;Enzymes;Etiology;Functional disorder;Funding;Genetic;Goals;Health;Homeostasis;Human;Image;insight;Literature;Logic;Medical;Mental Depression;Mental disorders;Metabolic Diseases;Methods;Monitor;Moods;Motivation;mouse model;National Institute of General Medical Sciences;Nervous System;neural circuit;Neuropeptides;neuropsychiatry;neuroregulation;neurotransmission;new therapeutic target;novel;Obesity;Output;Pain;Pain Disorder;Peptides;Physiological Processes;Physiology;receptor;Research;reuptake;Role;Schizophrenia;Signal Transduction;Signaling Molecule;Sleep;Sleep Disorders;Stress;Synapses;transmission process

PROJECT_TITLE: Cellular and Circuit Mechanisms of Neuropeptide Signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: PROJECT NARRATIVE Cells must be able to regulate when they will divide, migrate, or adopt a specialized cell identity. While all these cellular behaviors are important and necessary for an organism to properly develop, their execution at inappropriate times can lead to disease states. Studying the mechanisms that govern when cells should differentiate or migrate will elucidate new targets for the treatment of developmental disorders.

PI_NAMEs: STETTNISCH, SAMANTHA  (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Adopted;Affect;Anterior;Behavior;Biosensor;Brachyury protein;cancer cell;CDK2 gene;CDK4 gene;CDKN1C gene;cell behavior;Cell Cycle;Cell Cycle Arrest;Cell Cycle Inhibition;Cell Cycle Regulation;Cell Fate Control;cell fate specification;cell motility;Cell Transplantation;Cells;cellular imaging;Complex;Confocal Microscopy;convergent extension;Cues;Cyclin-Dependent Kinase Inhibitor;Cyclin-Dependent Kinases;Data;Development;developmental disease;Disease;Disseminated Malignant Neoplasm;Embryo;Exclusion;Floor;G1 Arrest;Gene Expression;gene regulatory network;Genes;Goals;in vivo;in vivo Model;insight;intercalation;Invaded;knock-down;Knowledge;Malignant Neoplasms;Mediating;migration;Modeling;Morphogenesis;Movement;mutant;new therapeutic target;notch protein;notochord;notochord development;novel;novel therapeutics;Organism;Outcome;overexpression;Phase;Play;Population;prevent;Process;progenitor;Proliferating;Publishing;Regulation;Research;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Specific qualifier value;stem cell fate specification;stem cell migration;stem cell population;stem cells;Structure;Testing;Tissues;transcription factor;Transcriptional Regulation;Transgenic Organisms;Up-Regulation;Work;Zebrafish;zebrafish development

PROJECT_TITLE: Cell Cycle Regulation of Cell Fate and Morphogenesis in D. rerio

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


PI_NAMEs: DAVE, SANDEEP  (contact)

PROJECT_TERMS: Bacteria;Basic Science;Biochemistry;Cancer Center Support Grant;cancer diagnosis;cancer genetics;cancer genome;cancer genomics;cancer therapy;Cellular biology;Collaborations;design;Development;Disease;Education;Epigenetic Process;epigenome;Evolution;Faculty;Focus Groups;Fostering;functional genomics;Funding;fungus;Gene Expression;Genetic;Genetic Recombination;Genomic Instability;Genomics;Goals;Grant;Growth;High-Throughput Nucleotide Sequencing;inter-institutional;Investments;Journals;Knowledge;Malignant Neoplasms;meetings;member;Mentors;Mentorship;microbiome;microorganism;model organism;Molecular Abnormality;Mutation;Oncology;Paper;Peer Review;Pre-Clinical Model;programs;Publishing;repaired;Research;Research Activity;Research Institute;Research Personnel;Resolution;Resource Sharing;Schools;Series;Source;structural biology;symposium;Technology;Technology Assessment;Training;training opportunity;transcriptome;tumor;tumorigenesis;Universities;Viral;Virus

PROJECT_TITLE: Cancer Genetics and Genomics Program


NIH_SPENDING_CATS: Biotechnology;Cancer;Hematology;Immunotherapy;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PI_NAMEs: CHAO, NELSON J. (contact)

PROJECT_TERMS: Adult;Antitumor Response;Area;Basic Science;bench to bedside;Cancer Center Support Grant;Cell Therapy;Cells;Childhood;Clinical;Clinical Investigator;Clinical Research;Clinical Trials;Collaborations;Disease;Doctor of Medicine;Doctor of Philosophy;doctoral student;Enrollment;Environment;Funding;genomic signature;Goals;graft vs host disease;Graft vs Tumor Effect;Grant;Hematologic Neoplasms;Hematopoietic;Hematopoietic Stem Cell Transplantation;Immune;immune activation;Immune response;Immunooncology;Immunosuppression;Immunotherapy;improved;improved outcome;Intervention Trial;Journals;Knowledge;Laboratories;member;multidisciplinary;next generation;novel strategies;oncology program;Paper;Patient-Focused Outcomes;Patients;Peer Review;Physicians;Postdoctoral Fellow;programs;Publishing;Research;Research Personnel;Role;Schools;Scientist;Signal Transduction;Stromal Cells;Therapeutic;Training;Translating;Translation Initiation;Translational Research;translational scientist;Translational trial;treatment trial;Universities;Work

PROJECT_TITLE: Immuno-Oncology Program


NIH_SPENDING_CATS: Aging

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Narrative Age is the single greatest risk factor for nearly all of the major causes of death and disability in the United States, including heart disease, most cancers, Alzheimer’s disease, diabetes and kidney disease. The relevance of this Training Program to public health is that we seek to train young scientists in research to understand the fundamental mechanisms of biological aging. It is our expectation that the scientists trained in our program will make significant contributions to improving health through the development of therapies that delay or prevent age-related diseases by directly targeting the molecular mechanisms of aging.

PI_NAMEs: PROMISLOW, DANIEL EDWARD;YOUNG, JESSICA ELAINE (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Biological;Grant;healthy aging;Training

PROJECT_TITLE: Biological Mechanisms of Healthy Aging Training Grant


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

PI_NAMEs: ASHLEY, DAVID M. (contact)

PROJECT_TERMS: Active Immunotherapy;Adult;Anniversary;Area;Bacterial Toxins;Basic Science;biobank;Biological Markers;Biological Models;Biological Products;Biotechnology;Brain;Brain Neoplasms;Brain Stem Glioma;Cancer Center Support Grant;Cancer Etiology;cancer immunotherapy;Cells;Central Nervous System Neoplasms;Cessation of life;chemotherapeutic agent;Child;Childhood;Childhood Brain Neoplasm;childhood cancer mortality;Childhood Malignant Brain Tumor;Clinical;clinical translation;Clinical Trials;Clinical Trials Design;clinically relevant;Collaborations;Communities;Comprehensive Cancer Center;Convection;cost;Data;Dendritic Cell Vaccine;design;Development;Diagnosis;Doctor of Philosophy;doctoral student;Dose;Drug Delivery Systems;drug testing;Enrollment;Ensure;epidemiology study;epigenomics;Etiology;experience;Foundations;functional genomics;Funding;Genetic study;Genomics;Glioma;Goals;Grant;Human;human disease;Human poliovirus;Image;imaging approach;immune checkpoint blockade;Immunoconjugates;Immunotherapeutic agent;Immunotherapy;Immunotoxins;improved;improved outcome;innovation;Intervention;Intervention Trial;invention;Journals;Maintenance;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;Medical;Melanoma;member;metabolomics;Mission;Molecular;Molecular Epidemiology;mouse model;Mus;Mutation;National Cancer Institute;Nervous System;neuro-oncology;Neurocognitive;New Agents;new technology;next generation;novel;novel therapeutics;Oncogenes;oncolytic virotherapy;Operative Surgical Procedures;Paper;Patients;Pediatric Neoplasm;Peer Review;Peptides;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Physical Function;Postdoctoral Fellow;pre-clinical;Pre-Clinical Model;Preclinical Testing;predictive modeling;Prevention;Prevention approach;Primary Brain Neoplasms;programs;Proteomics;Publications;Publishing;PubMed;Quality of life;Radioisotopes;Recombinants;Renal Carcinoma;Reporting;repository;Research;Research Personnel;Resistance;Resources;Sampling;Schools;screening;Screening procedure;subcutaneous;Supportive care;Techniques;Technology;Testing;Therapeutic;Training;Transgenic Model;Translating;translational study;treatment trial;trial design;tumor;Tumor Markers;Tumor Suppressor Proteins;United States;Universities;Vaccines;Virotherapy;Xenograft Model;Xenograft procedure;young adult

PROJECT_TITLE: Neuro-Oncology Program


PI_NAMEs: KIRSCH, DAVID GUY (contact)

PROJECT_TERMS: Ablation;acute toxicity;American College of Radiology Imaging Network;Animal Experiments;Area;Basic Science;Biomedical Engineering;Biopsy;Cancer Center Support Grant;cancer imaging;Cancer Patient;clinical imaging;Clinical Investigator;Clinical Research;Clinical Trials;Collaborations;cone-beam computed tomography;Dedications;Detection;detection method;Diagnosis;Diagnostic Imaging;Diagnostic Neoplasm Staging;Disease;Dose;Early Diagnosis;early phase clinical trial;Eastern Cooperative Oncology Group;Enrollment;Fostering;Funding;Goals;Grant;Image;image guided;image guided therapy;Image-Guided Surgery;imaging biomarker;imaging modality;imaging program;imaging scientist;improved;improved outcome;in vivo;Infrastructure;innovation;Institution;interdisciplinary approach;Intervention Trial;Journals;Late Effects;Magnetic Resonance Imaging;Malignant Neoplasms;Medical;Medical center;medical countermeasure;member;microCT;Microscopy;National Institute of Allergy and Infectious Disease;National Institute of Biomedical Imaging and Bioengineering;Normal tissue morphology;Oncology;oncology program;Paper;Patient-Focused Outcomes;Patients;Peer Review;PET/CT scan;Phase I Clinical Trials;Population;Positioning Attribute;Positron-Emission Tomography;preclinical imaging;Primary Neoplasm;Procedures;programs;Publishing;Radiation;radiation delivery;Radiation Injuries;Radiation Oncologist;Radiation Oncology;radiation response;Radiation therapy;Radiation Tolerance;Radiation-Induced Cancer;Radiobiology;radiologist;Radiology Specialty;randomized, clinical trials;Research;Research Personnel;Research Support;response;Roentgen Rays;Schools;screening;Screening for cancer;Series;Services;side effect;simulation;Staging;standard of care;Structure;Therapeutic;Tissues;Toxic effect;Translating;Translational Research;treatment planning;treatment trial;tumor;Tumor Tissue;Universities;X-Ray Computed Tomography

PROJECT_TITLE: Radiation Oncology Program


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Urologic Diseases

PI_NAMEs: ANTONIA, SCOTT J. (contact)

PROJECT_TERMS: Address;angiogenesis;Anus;base;Bladder;Cancer Biology;cancer cell;Cancer Center Support Grant;Cancer Control;cancer genetics;cancer genomics;cancer health disparity;career development;Caring;Clinical assessments;clinical practice;Clinical stratification;Clinical Trials;Clinical Trials Network;co-clinical trial;Collaborations;Colorectal;Communities;community engagement;Community Outreach;cost;Development;Disease;Disparity;drug development;drug discovery;drug testing;Education;EGF gene;Enrollment;Esophagus;Faculty;Fibroblast Growth Factor Receptors;Focus Groups;Funding;Goals;Grant;Head and Neck Cancer;health care delivery;health economics;health equity;Hepatobiliary;Homeostasis;Immune system;Immunotherapy;improved;Individual;insight;Intervention Trial;Investigational Therapies;investigator-initiated trial;Journals;Kidney;Lead;Lung;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of thorax;Malignant Neoplasms;Measures;meetings;Melanoma;member;Mentors;National Clinical Trials Network;Outcome;Pancreas;Paper;Pathway interactions;Patient Outcomes Assessments;Patients;Peer Review;Phase;Platelet-Derived Growth Factor;Population;Population Sciences;Postdoctoral Fellow;Pre-Clinical Model;precision oncology;Precision therapeutics;Process;Program Development;programs;Prostate;Publications;Publishing;Race;Research;Research Personnel;Role;Sarcoma;Schools;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Site;Small Intestines;Solid Neoplasm;Stomach;Structure;Students;synergism;Therapeutic;Transforming Growth Factor beta;Translating;translational potential;Translational trial;treatment trial;Tumor Biology;tumor microenvironment;Universities;Urogenital Cancer;Vascular Endothelial Growth Factors

PROJECT_TITLE: Precision Cancer Medicine and Investigational Therapeutics


NIH_SPENDING_CATS: Cancer;Immunotherapy

PI_NAMEs: PENDERGAST, ANN MARIE  (contact)

PROJECT_TERMS: Academy;aluminum sulfate;American Association for the Advancement of Science;anti-cancer research;Appointment;Area;Award;base;Basic Science;Cancer Biology;Cancer Center Support Grant;CAR T cell therapy;career;Clinical;Collaborations;Development;DNA Sequence Alteration;Ensure;Environment;Epigenetic Process;Event;Faculty Recruitment;Feedback;Fostering;Foundations;Funding;Future;Goals;Grant;Immune checkpoint inhibitor;insight;Institution;interest;International;Joints;Journals;Leadership;Malignant Neoplasms;meetings;member;Metabolism;metabolomics;Modification;Molecular;next generation;novel;novel anticancer drug;Oral;Paper;Peer Review;Phenotype;Pilot Projects;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;posters;Production;programs;Publications;Publishing;Records;recruit;Research;Research Personnel;Research Project Grants;Schools;Scientist;Series;Signal Transduction;Signaling Protein;Solid Neoplasm;Students;success;Targeted Research;targeted treatment;Therapeutic;therapeutic development;Training;tumor;Tumor Biology;tumor metabolism;tumorigenesis;Uncertainty;Universities

PROJECT_TITLE: Cancer Biology Program


NIH_SPENDING_CATS: Brain Disorders;Genetics;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: Project Narrative Urea cycle disorders are a group of very rare genetic diseases that cause the build-up of ammonia in the body, which can cause brain damage or death. DNA sequencing of urea cycle genes is used to diagnose patients, but often the test results are not clear because not all genetic changes cause disease. We are bringing together experts from around the world to determine which genetic changes in urea cycle genes cause disease and require treatment.

PI_NAMEs: AH MEW, NICHOLAS ;CALDOVIC, LJUBICA MORIZONO (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: Acceleration;accurate diagnosis;actionable mutation;Acute;Affect;Alleles;Ammonia;Archives;Benign;Birth;Brain;Brain Death;Brain Edema;Brain Injuries;Carbamyl Phosphate;Case Study;Catalogs;Cessation of life;Child;Classification;Clinical;clinical care;clinically actionable;clinically significant;ClinVar;Collaborations;Coma;Conflict (Psychology);cost;Data;Databases;Dedications;Deposition;Developmental Disabilities;Diagnosis;Diagnostic;Disease;disease classification;DNA sequencing;Early Diagnosis;Enzymes;Executive Dysfunction;experience;falls;Foundations;Functional disorder;Genes;Genetic;genetic counselor;genetic variant;Health Professional;Hyperammonemia;improved;Inborn Errors of Metabolism;inborn urea cycle disorder;Incidence;Individual;Information Systems;Intellectual functioning disability;International;Laboratories;Life;Ligase;Link;Literature;loss of function;member;Methods;Mitochondria;Molecular;Molecular Diagnosis;Molecular Genetics;Mutation;N acetyl L glutamate;N-carbamylglutamate;National Institute of Child Health and Human Development;Natural History;Nervous System Trauma;Neurocognitive Deficit;Neurologic Symptoms;Neuropsychology;next generation sequencing;Organ;Ornithine Carbamoyltransferase;Ornithine carbamoyltransferase deficiency;Pathogenicity;Patient Care;Patients;Persons;Physicians;Population;proband;Production;public database;Publishing;rare genetic disorder;Recommendation;Registries;Reporting;Research;Research Priority;Review Literature;screening;Severity of illness;Source;Subgroup;Test Result;Toxic effect;Urea;urea cycle;Urea cycle disorders;Variant;variant of unknown significance;willingness;working group

PROJECT_TITLE: Expert curation of sequence variants in the proximal urea cycle genes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-B(50)R]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Aging;Arthritis;Assistive Technology;Behavioral and Social Science;Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Physical Rehabilitation;Rehabilitation

ORG_CITY: BINGHAMTON

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

PHR: Integrated load sensing in total knee replacement implants would allow for early warning of load-related failures or other biomechanical problems, but powering such devices is an ongoing challenge. We propose a load measurement system that is self-powered using energy harvested from joint forces during activities of daily living. The goal of this research is to design, manufacture and test prototype self-powered sensors in realistic in vitro loading conditions as a step towards clinical applications.

PI_NAMEs: TOWFIGHIAN, SHAHRZAD  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Accidents;Activities of Daily Living;Address;Arthritis;artificial neural network;biomaterial compatibility;Biomechanics;Cadaver;Cells;Ceramics;Charge;Classification;Clinic;Clinic Visits;Clinical;clinical application;clinical trial readiness;Communication;Computers;cost;COVID-19 pandemic;Creativeness;Data;Data Aggregation;data exchange;Decision Making;Degenerative polyarthritis;density;design;Devices;Early Diagnosis;Early identification;Effectiveness;Electricity;Electrodes;Electromagnetics;Electronics;Electrostatics;Energy harvesting;Energy-Generating Resources;Ensure;Epidemic;Exhibits;experimental study;Exposure to;Failure;feature extraction;flexibility;functional improvement;Goals;Health;Health Personnel;Healthcare;Housing;Implant;implantable device;improved;In Vitro;in vivo;instrument;integrated circuit;joint loading;Joints;kinematics;Knee;knee replacement arthroplasty;Lead;Libraries;Ligaments;Link;manufacture;Materials Testing;Measurement;Measures;mechanical load;Mechanics;Medical Care Costs;Memory;Molecular;Monitor;Motion;new technology;Older Population;operation;Operative Surgical Procedures;Outcomes Research;Output;Pain;Patients;Pattern;Performance;Periodicity;Persons;Physiological;Polyethylenes;Preclinical Testing;premature;Process;Property;Prosthesis;prosthetic alignment;prototype;Reading;rechargeable battery;reconstruction;Rehabilitation therapy;Replacement Arthroplasty;Research;Risk;Second Look Surgery;sensor;sensory integration;sensory system;signal processing;Signal Transduction;Specimen;Sports;Structure;Surface;System;Techniques;Technology;telehealth;Telemetry;Testing;Texture;therapy development;Thick;Time;Titanium;Training;Transducers;transmission process;treatment strategy;ultra-high molecular weight polyethylene;Visit;voltage;Walking;Weight;wireless;Work

PROJECT_TITLE: Self-Powered Load Sensors for Total Knee Replacement Health Monitoring

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

PI_NAMEs: MCDONNELL, DONALD P (contact)

PROJECT_TERMS: Basic Science;Biological;Biological Markers;Breast Cancer Treatment;Cancer Center Support Grant;cancer subtypes;career development;Characteristics;Clinical Research;Clinical Trials;Collaborations;cost effective;Detection;Endocrine;Enrollment;Estrogen receptor positive;Faculty;Fostering;Funding;Genetic Heterogeneity;Genetic Variation;Goals;Grant;Growth;Health Services Research;Healthcare;improved;improved outcome;individual patient;inflammatory breast cancer;Infrastructure;innovation;interest;Intervention Trial;Journals;Knowledge;Malignant Breast Neoplasm;Malignant Female Reproductive System Neoplasm;Malignant Neoplasms;member;Mentors;multidisciplinary;novel strategies;Paper;Pathologic;Pathway interactions;Patient Preferences;Patients;Peer Review;Postdoctoral Fellow;Prevention strategy;Productivity;Program Development;programs;Publishing;Research;Research Personnel;Resistance;Resources;Risk;Schools;Structure;Students;Therapeutic;therapeutic development;therapeutic target;Training;translational potential;Translational Research;treatment trial;triple-negative invasive breast carcinoma;tumor;Universities;Validation;Woman;women's outcomes

PROJECT_TITLE: Women's Cancer Program


NIH_SPENDING_CATS: Cancer

PI_NAMEs: ARMSTRONG, ANDREW J (contact)

PROJECT_TERMS: Advocate;Affect;Amendment;anti-cancer research;authority;cancer care;Cancer Center Support Grant;Cancer Patient;Clinical;Clinical Investigator;Clinical Research;Clinical Trials;Committee Membership;Communities;Community Health Education;Diagnostic;Disease;Doctor of Philosophy;Education;Enrollment;Ensure;falls;improved;Intervention;Malignant Neoplasms;meetings;member;Monitor;multidisciplinary;Patient Care;Patients;Peer Review;Pharmacists;Preventive;Process;programs;Prospective Studies;Protocols documentation;Research;Research Design;Research Personnel;Research Priority;Resources;Review Committee;Scientist;System;Tissues;tool;Voting;Work

PROJECT_TITLE: Protocol Review and Monitoring System