NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Neurosciences;Pediatric;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Relevance to Public Health  Prenatal stress is a known risk factor for negative child health outcomes, and disproportionately affects families facing racial and economic marginalization. We will examine the effects of preconception stress exposure on pregnancy health and neurodevelopmental outcomes in the child from birth to age 10, as well as the extent to which prenatal nutritional health and social support foster resilience in stressful environments. The findings from this study will advance knowledge on tailored approaches to optimize prenatal health and child development and reduce persistent health inequities.

PI_NAMEs: HIPWELL, ALISON E (contact)

PROGRAM_OFFICER_NAME: ZANETTI, KRISTA A

PROJECT_TERMS: Address;Advanced Development;Affect;Age;Attenuated;Award;Biological Factors;Black race;Buffers;Child;Child Development;Child Health;Childbirth;Childhood;Chronic stress;cohort;Communities;community violence;Conceptions;contextual factors;Corticotropin-Releasing Hormone;Data;data integrity;Development;Discrimination;Disease;disease model;diverse data;Economics;Enrollment;Ensure;Environment;executive function;experience;Exposure to;Family;Fostering;Funding;Future;Generations;girls;Health;health care availability;health care quality;health inequalities;Health Personnel;high risk;Hydrocortisone;hypothalamic-pituitary-adrenal axis;improved;Individual;Inequity;Infant;innovation;Knowledge;Lead;Low income;marginalization;marginalized population;Maternal and Child Health;maternal stress;Measurable;Measures;Mediating;Modeling;multi-racial;multidisciplinary;neurodevelopment;Neurodevelopmental Problem;Nutritional;Nutritional status;offspring;Outcome;Participant;participant enrollment;participant retention;Pathway interactions;people of color;personalized approach;Phase;Physiology;Placenta;Population Heterogeneity;Pregnancy;pregnancy health;pregnant;prenatal;prenatal exposure;prenatal health;prenatal stress;Prevention approach;Production;promote resilience;protective factors;Protocols documentation;Public Health;Qualifying;Race;recruit;Regulation;Research;resilience;resilience research;Resources;response;Risk;Risk Factors;Sampling;Science;sex;Short-Term Memory;Site;social health determinants;Social support;socioeconomics;Specific qualifier value;Specificity;Stress;stress reactivity;stressor;success;System;theories;transmission process;Urban Population;Woman;Work

PROJECT_TITLE: Resilience to prenatal stress: Implications for offspring health and neurodevelopment


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Gene Therapy;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: CAMBRIDGE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_FIPS: US

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: Project Narrative The goal of gene therapy is to precisely treat diseases by delivering nucleic acids that strike at the genetic root of the disease. However, a key bottleneck in the application of these technologies are appropriate delivery vehicles that do not initiate strong immune responses. Here we propose to utilize mammalian virus-like proteins to engineer fully endogenous vectors that have the potential for efficient, modular, and non-immunogenic nucleic acid delivery for eventual applications in neurological disease treatment.

PI_NAMEs: LASH, BLAKE  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Adenoviruses;Antibodies;Binding;Binding Proteins;Binding Sites;Bioinformatics;Biological;Biological Assay;Biological Process;bioluminescence imaging;Body System;candidate identification;Capsid;Capsid Proteins;Cell Differentiation process;cell type;Cells;Central Nervous System;Clinic;Communication;Computational Biology;Cre lox recombination system;cytokine;delivery vehicle;Dependovirus;design;Development;Disease;Dose;Engineering;env Gene Products;Environment;Epitopes;Evolution;extracellular vesicles;Gene Delivery;gene editing technology;gene therapy;Gene Transduction Agent;Gene Transfer;Generations;Genes;Genetic;Genetic Diseases;genome sequencing;Goals;Homologous Gene;human embryonic stem cell line;Human Genome;Immune response;Immune system;Immunity;immunogenic;immunogenicity;Immunoprecipitation;In Vitro;in vivo;Inflammation;Innate Immune Response;intercellular communication;interest;Investigation;Knock-in;Knock-out;Learning;Lentivirus;mammalian genome;Maps;Measures;Mediating;Mentorship;Messenger RNA;Methods;Molecular Biology;Monitor;mRNA delivery;Mus;mutant;nanoparticle;Nervous System Disorder;Nucleic Acid Binding;nucleic acid delivery;Nucleic Acids;Organ;Pathogenicity;Patients;programs;Protein Secretion;Proteins;Reporter;Research;Research Personnel;response;Retroelements;Retrotransposon;Retroviridae;Risk;RNA;RNA Binding;Role;self assembly;Serum;side effect;skills;stem cells;Structure;System;T cell response;Techniques;Technology;Tertiary Protein Structure;Therapeutic;therapeutic gene;Tissues;Tropism;Validation;vector;Viral;Viral Vector;Virus;Work

PROJECT_TITLE: Interrogation of retroelement-derived proteins for functional gene transfer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


ADMINISTERING_IC: DA

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: SAN DIEGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: SAN DIEGO STATE UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative There is an urgent need to address inequities in opioid overdose deaths in Black Americans. For this Racial Equity Visionary Award, I propose an innovative intervention using structural competency, peer navigators, and culturally grounded opioid use disorder education to engage Black patients to connect with local providers for effective treatment to save lives. This work draws on my expertise and expands my research to reduce inequities in overdose deaths.

PI_NAMEs: SMILEY, SABRINA LYNN (contact)

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: Address;Award;Black American;black patient;Black Populations;Black race;Buprenorphine;buprenorphine treatment;California;Caring;Clinic;Clinical Trials;Communities;community engaged intervention;community engagement;Competence;COVID-19 pandemic;design;Disparity;Education;effective therapy;Evidence based intervention;feasibility testing;Foundations;Funding;Health Services Accessibility;Healthcare;implementation evaluation;implementation science;improved;Income;Inequity;innovation;Insurance;Intervention;Investigation;Medical;Methods;National Institute of Drug Abuse;Neighborhood Health Center;Not Hispanic or Latino;novel;Office Visits;opioid epidemic;opioid mortality;opioid overdose;opioid use disorder;Overdose;overdose death;patient-level barriers;Patients;peer;Phase;Prevalence;Privatization;Procedures;Protocols documentation;Provider;provider-level barriers;Publishing;racial disparity;Racial Equity;Randomized, Controlled Trials;Research;Role;routine care;sociologist;System;Testing;Training;treatment services;underserved area;Underserved Population;Work

PROJECT_TITLE: Racial Equity in Systems to Treat Opioid Use Disorder for Everyone (RESTORE): A Pilot Randomized Controlled Trial


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Organ Transplantation;Racial and Ethnic Minority Health Research;Transplantation

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Renal risk variants in the gene APOL1 have been associated with increased risk of chronic kidney disease in individuals with African American (AA) ancestry. Within the APOLLO Consortium, APOLLO Clinical Center 12 will work collaboratively to study the impact of this gene on long-term outcomes in renal transplant recipients that receive a kidney from an AA donor and on renal function of AA living donors by leveraging the infrastructure and collaborations established in Phase I. In Phase 2, we will maximize clinical data capture, recruitment of AA living donors, measurement of urine albumin-to-creatinine ratio, and biospecimen collection according to the goals of the Consortium.

PI_NAMEs: HSU, CHI-YUAN  (contact);PARK, MEYEON

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: Acceleration;Acute;Address;African American;African ancestry;Albumins;Allografting;American;Antibodies;APOL1 gene;Apolipoproteins;Bacterial Infections;Biology;Biopsy;Blood;California;Chronic Kidney Failure;clinical center;Clinical Data;cohort;Collaborations;Collection;Computerized Medical Record;Consent;Cost Savings;Counseling;Creatinine;Data;Databases;digital pathology;Disparity;DNA;Donor person;Education;Eligibility Determination;Enrollment;Ensure;Environmental Risk Factor;ethnic difference;European;Evaluation;Face;Failure;follow-up;gene interaction;Gene Mutation;Genes;Genetic;genetic risk factor;Genotype;Goals;graft failure;graft function;Graft Survival;Hand;Health Care Costs;high risk;HLA Antigens;Immunosuppression;improved;Individual;Infrastructure;Kidney;kidney biopsy;Kidney Failure;Kidney Transplantation;Lesion;Living Donors;living kidney donor;Longterm Follow-up;Los Angeles;Measurement;Measures;Medical;Medical center;member;novel;Observational Study;Organ;Organ Procurements;Outcome;Participant;participant enrollment;Patients;Phase;Phenotype;Policies;post-transplant;Prevalence;primary outcome;programs;prospective;Proteinuria;Quality of life;racial difference;recruit;Recurrent disease;Registries;Renal function;Reporting;repository;Research;response;Risk;Risk Factors;risk variant;Role;Safety;San Francisco;secondary outcome;Serum;Site;Slide;Specimen;Time;Transplant Recipients;transplant registry;Transplantation;United Network for Organ Sharing;United States National Institutes of Health;Universities;Urine;Variant;Virus Diseases;Work

PROJECT_TITLE: 12/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Hypertension;Nutrition;Physical Activity;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE Reduction of blood pressure to optimal levels is a major public health priority. Lifestyle modifications, blood pressure monitoring and anti-hypertensive medication have proven to reduce blood pressure. We will conduct a hybrid study to assess the implementation and effectiveness of a community health worker led hypertension prevention and control.

PI_NAMEs: SHRESTHA, ARCHANA ;SPIEGELMAN, DONNA L (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, MAKEDA J

PROJECT_TERMS: Address;Adopted;Adult;Alcohols;Anti-Hypertensive Agents;Awareness;Behavioral;Belief;Blood Pressure;blood pressure control;Blood Pressure Monitors;blood pressure reduction;Blood Vessels;Body Weight decreased;cardiovascular disorder risk;Cessation of life;Client;Communities;Community Health Aides;Community Healthcare;comparative;Coronary heart disease;cost;cost effectiveness;Data;Diastolic blood pressure;Disease;Eating;Economics;Effectiveness;effectiveness evaluation;effectiveness/implementation study;empowerment;Event;Evidence based intervention;Expenditure;experience;fruits and vegetables;Geography;good diet;Government;Health;Health care facility;Health Personnel;Health system;healthcare burden;Healthcare Systems;High Prevalence;high salt diet;Home;Household;Human Resources;Hybrids;Hypertension;hypertension control;hypertension prevention;hypertension treatment;implementation barriers;implementation evaluation;implementation outcomes;implementation science;implementation strategy;implementation trial;improved;incremental cost;Individual;Intake;Interruption;Life Style;Life Style Modification;low and middle-income countries;low health literacy;Measures;medical supply;medication compliance;Medicine;Methods;Modeling;mortality;Nepal;Outcome;Participant;Patients;Peer Pressure;Pharmaceutical Preparations;Physical activity;physical inactivity;population health;Positioning Attribute;Predisposition;premature;Prevalence;prevent;Prevention;Primary Health Care;primary outcome;Primary Prevention;Protocols documentation;Provider;Public Health;public health priorities;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;recruit;Reporting;Resource-limited setting;response;Risk Factors;saturated fat;secondary outcome;Secondary Prevention;Self Efficacy;Sodium;standard of care;Stroke;Time;Translating;uptake

PROJECT_TITLE: Community Health Worker Led Hypertension Prevention and Control (CHPC) in Nepal: An Implementation Trial

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cocaine;Neurosciences;Physical Injury - Accidents and Adverse Effects;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: LEXINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: This investigation may lead to discovery of a promising protein drug candidate to be developed for treatment of aldicarb poisoning in the future.

PI_NAMEs: ZHAN, CHANG-GUO ;ZHENG, FANG  (contact)

PROGRAM_OFFICER_NAME: SPRIGGS, SHARDELL M

PROJECT_TERMS: absorption;Acetylcholinesterase;Acetylcholinesterase Inhibitors;Acute;acute toxicity;Aerosols;Aftercare;aged;Air;Aldicarb;Animal Model;Animals;Atropine;Binding;Biological Assay;bioscavenger;blood-brain barrier crossing;Brain;Butyrylcholinesterase;Carbamates;Categories;Cavia;Chemical Warfare;Chemicals;cholinergic;Clinical;clinical candidate;clinical development;Cocaine;Cocaine use disorder;Computer Models;computer studies;Control Groups;Convulsions;Corn Oil;cyclosarin;Data;dermal exposure;Development;Dose;drug candidate;Drug Metabolic Detoxication;Engineering;Enzymes;Evaluation;experience;experimental study;exposure route;Exposure to;Future;Hour;Human Engineering;Hydrolase;Hydrolysis;Hyperactivity;immunogenicity;improved;In Vitro;in vivo;Intoxication;intraperitoneal;Investigation;Lead;lead optimization;Lethal Dose 50;Libraries;Literature;mass casualty;medical countermeasure;Molecular;mortality;Mus;nerve agent;neurotoxicity;novel;Oral;Organophosphorus Compounds;Outcome;Oximes;Paraoxon;Pesticides;pharmacokinetics and pharmacodynamics;Phosphorylation;physical property;Poisoning;Polymers;preclinical development;programs;Proteins;rational design;Rattus;Reaction;Reporting;Research;Safety;Sarin;Security;Soman;success;tabun;Talc;Testing;Toxic effect

PROJECT_TITLE: Long-acting aldicarb hydrolase as a medical countermeasure for aldicarb poisoning

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-F(50)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Childhood Injury;Clinical Research;Neurosciences;Pediatric;Prevention;Unintentional Childhood Injury

ORG_CITY: Columbus

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Continued media coverage of the potential long-term effects of contact sports, such as tackle football, has created significant public health concerns about the risk of childhood participation. This study will provide critical contributions to our scientific knowledge on the neurodevelopmental effects of youth tackle football across the first year of participation and has the potential to provide a key understanding of the risks and benefits of participation. Thus, the proposed research is consistent with the Pediatric Trauma and Critical Illness Branch of the NICHD scientific priority to prevent adverse health outcomes and developmental sequelae in children by improving early detection and by identifying optimal time periods for prevention and intervention efforts of repetitive brain injuries.

PI_NAMEs: CACCESE, JACLYN B. (contact);SAYGIN, ZEYNEP

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: Adult;adverse childhood events;Age;attentional control;Attenuated;Behavior;Benefits and Risks;Brain;Brain Injuries;Child;Childhood;Chronic Brain Injury;Clinical;Cognition;cognitive function;cognitive testing;Collaborations;college;Communities;community engagement;Community Outreach;contact sports;Costs and Benefits;Critical Illness;critical period;Data;Decision Making;Development;Early Diagnosis;Enrollment;Equilibrium;Etiology;executive function;Exhibits;Exposure to;Functional impairment;Funding;Future;Goals;head impact;Health;high school;Impaired cognition;Impairment;improved;instrument;Intervention;Knowledge;Long-Term Effects;Manufactured football;Measures;Mission;modifiable risk;multidisciplinary;myelination;National Institute of Child Health and Human Development;Nature;Neck;Nervous System Trauma;neural;Neurodegenerative Disorders;neurodevelopment;Neurodevelopmental Disorder;neurodevelopmental effect;neuroimaging;neuromuscular;neurophysiology;Ohio;Outcome;Parents;Patients;pediatric trauma;Performance;Pilot Projects;Play;Policies;Policy Maker;prevent;Prevention;Productivity;programs;Public Health;Reaction Time;Recording of previous events;Reporting;Research;Rest;Risk;Risk Factors;Risk Reduction;Seasons;Short-Term Memory;Sports;Structure;Testing;Time;vestibular system;Visual;white matter;Work;Youth;youth sports

PROJECT_TITLE: Understanding the neurodevelopmental effects  of youth tackle football participation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-N(02)M]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: PEDIATRICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Diffuse intrinsic pontine glioma (DIPG) is a deadly disease with few treatment options. In this proposal, we will study epigenetic dependence of DIPG to gain mechanistic insight into pathogenesis of and to identify drug targets for this deadly disease.

PI_NAMEs: ZHANG, ZHIGUO  (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: ACVR1 gene;Amino Acids;Area;ATP phosphohydrolase;brahma;Brain;Brain region;Catalytic Domain;cell growth;Cells;chemotherapy;Childhood Glioma;Chromatin;Chromatin Remodeling Factor;Cleavage Under Targets and Release Using Nuclease;Clinical;Complex;CRISPR screen;Data;Dependence;Diagnosis;Diffuse intrinsic pontine glioma;diffuse midline glioma;Disease;DNA Sequence Alteration;driver mutation;Drug Targeting;effective therapy;Epigenetic Process;epigenome;epigenomics;Extracellular Matrix;fitness;Gene Expression;Gene Expression Profile;Gene Silencing;Genes;Genetic Transcription;Glioma;glioma cell line;Growth;Heterozygote;Histone H3;In Vitro;in vivo;inhibitor;insight;Invaded;Lysine;Malignant Neoplasms;Mediating;Methionine;Methods;Methylation;Molecular;mouse model;mutant;Mutation;neoplastic cell;neurodevelopment;Neurons;new therapeutic target;Normal Cell;Paracrine Communication;paralogous gene;Pathogenesis;Pathogenicity;patient derived xenograft model;Patients;Play;Pontine structure;pre-clinical;programs;Proliferating;protein H(3);Proteins;recruit;Regulatory Element;Research;Role;SMARCA4 gene;Somatic Mutation;SWI/SNF Family Complex;Synapses;Testing;therapeutic target;Tissues;transcription factor;transcriptome sequencing;tumor;tumor growth;tumor initiation;Tumor Suppressor Genes;tumorigenesis;Variant;Work;Writing

PROJECT_TITLE: Epigenetic dependence of diffuse midline glioma with H3K27M mutation

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative The ECHO Cohort Study is an extensive resource for elucidating the roles of environmental and genetic characteristics that affect child health. The JHU/RTI Data Analysis Center will advance ECHO research by providing state-of-the-art systems for data collection and management, innovative, unbiased analyses, and by publicizing high quality, well-documented ECHO data to promote informative analyses by the scientific community at-large.

PI_NAMEs: CATELLIER, DIANE J;JACOBSON, LISA P (contact)

PROGRAM_OFFICER_NAME: PARK, CHRISTINA H

PROJECT_TERMS: Acceleration;Accountability;Address;Adoption;adverse outcome;Affect;analytical method;Attention;Biometry;Characteristics;Child Development;Child Health;Childhood;cohort;Cohort Studies;Collaborations;Collection;Communication;Communities;Complex;Data;Data Analyses;Data Collection;data ecosystem;data framework;data integration;data management;data quality;Data Science;data sharing;data standards;database structure;Dedications;design;Development;Disparate;Ensure;Environment;Environmental Exposure;Environmental Health;Epidemiology;epidemiology study;Epigenetic Process;equity, diversity, and inclusion;experience;FAIR principles;Familiarity;Family;flexibility;Fostering;Generations;Genetic;Genetic Predisposition to Disease;Geography;Health;Individual;Informatics;Information Systems;Infrastructure;innovation;Institution;International;Investigation;Knowledge;Leadership;Life Cycle Stages;Link;longitudinal analysis;Measures;Metadata;method development;Methodology;Methods;Mission;multilevel analysis;next generation;novel;Outcome;Outcomes Research;Participant;Pediatric Research;Philosophy;Population;Principal Investigator;Productivity;programs;Protocols documentation;Publications;Reporting;Reproducibility;Research;Research Design;Research Infrastructure;Research Methodology;Research Personnel;Research Proposals;Resources;Role;Science;Scientist;Secure;Site;social;Specific qualifier value;statistics;Structure;success;support tools;Surveys;synergism;System;tool;tool development;Translating;United States National Institutes of Health;Universities;Visualization

PROJECT_TITLE: ECHO DAC (Environmental Influences on Child Health Outcomes Data Analysis Center)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-G(51)R]


PHR: Narrative Genetic variants in APOL1 commonly found in people of Western Sub-Saharan Africa ancestry are associated with kidney diseases such as Focal Segmental Glomerulosclerosis, Hypertension Attributed-End Stage Kidney Disease, and HIV-Associated Nephropathy, the presence of 2 APOL1-renal risk variants (RRV) in deceased donors is associated with 2-to-4-times higher risk of renal graft loss in the recipient, and living donors (LDs) withAPOL1 RRVs may be at risk for kidney disease. The NIH established the “APOL1 Long-term Kidney Transplantation Outcomes” (APOLLO) U01 Consortium in 2017 consisting of 13 clinical centers (CCs) with 4 paired core Centers to study the role of APOL1 in transplant outcomes. This application from CC3 (Johns Hopkins/Saint Louis University) seeks to build on and extend the findings of the APOLLO study to inform clinical practice by: a) providing data regarding the effects of APOL1 genotype on outcomes of the recipients of kidneys from AA donors, b) providing data regarding the effects of APOL1 genotype on long-term renal functional outcomes of AA LDs and their recipients, and c) establishing a resource of clinical information, genetic data and biological specimens for the APOLLO Consortium and other future researchers through the NIDDK Central Repository.

PI_NAMEs: BRENNAN, DANIEL CONLON (contact);LENTINE, KRISTA L

PROJECT_TERMS: Acceleration;Acute;Address;Africa South of the Sahara;African American;African ancestry;AIDS-Associated Nephropathy;Albumins;Alleles;Allografting;American;Antibodies;APOL1 gene;Apolipoproteins;Bacterial Infections;Biological;Biopsy;Blood;Clinical;clinical center;Clinical Data;clinical practice;cohort;Consent;Cost Savings;Counseling;Creatinine;Data;digital pathology;Disparity;DNA;Education;End stage renal failure;Enrollment;Ensure;ethnic difference;European;Evaluation;Face;Failure;Focal and Segmental Glomerulosclerosis;follow-up;functional outcomes;Future;gene interaction;Genes;Genetic;genetic variant;Genotype;Geography;graft failure;Graft Survival;Health Care Costs;high risk;HLA Antigens;HTATIP2 gene;Hypertension;Immunosuppression;improved;Individual;Kidney;kidney allograft;kidney biopsy;Kidney Diseases;Kidney Failure;Kidney Transplantation;Lesion;Living Donors;Longterm Follow-up;Measures;Medical;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Organ;Outcome;Outcome Assessment;Outcome Study;Participant;Patients;Pattern;Persons;Phase;Phenotype;Policies;post-transplant;Prevalence;primary outcome;programs;prospective;Proteinuria;Quality of life;racial difference;rate of change;recruit;Recurrent disease;Registries;Renal function;Reporting;repository;Research;Research Design;Research Personnel;Resources;Risk;risk variant;Role;Safety;Sampling;secondary outcome;Serum;Site;Slide;Specimen;Time;Transplant Recipients;Transplantation;United Network for Organ Sharing;United States;United States National Institutes of Health;Universities;Urine;Variant;Virus Diseases;Vital Status

PROJECT_TITLE: 3/14 ApoL1 Long-Term Kidney Transplantation Outcomes Network (Apollo) Clinical Center


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Climate-Related Exposures and Conditions;Clinical Research;Data Science;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Valley Fever

ORG_CITY: TEMPE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: This project will construct novel large-scale, multi-host mechanistic models of the Hantavirus Pulmonary Syndrome (HPS) and Valley Fever (coccidioidomycosis) diseases in the Phoenix, Arizona metro area to investigate the stability versus context-sensitivity of hosts as disease reservoirs and identify key future data sources required to improve forecasting and identify effective interventions aimed at reducing disease burden. Both diseases are endemic to the southwestern United States and are believed to be spread by rodent hosts, but they are caused by different types of pathogens (viruses and fungi, respectively) and show divergent case trends. For training and outreach, the project will implement and evaluate initiatives to (i) communicate results in public outreach events; (ii) construct a course-based undergraduate research experience (CURE) focused on disease modeling; and (iii) build capacity for researching Valley Fever and mitigating outbreaks.

PI_NAMEs: STERNER, BECKETT  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Area;Arizona;behavior influence;Biological Models;Biology;burden of illness;Coccidioidomycosis;Communication;Complex;Data;Data Science;Data Sources;desert fever;Disease;disease model;Disease Outbreaks;Disease Reservoirs;Ecosystem;Education and Outreach;Educational workshop;effective intervention;Endemic Diseases;environmental change;Event;field study;fungus;Future;Genetic;Habitats;Hantavirus;Hantavirus Pulmonary Syndrome;Health;Human;improved;interdisciplinary approach;land use;life history;Link;Mediating;Modeling;Monitor;National Institute of General Medical Sciences;novel;outbreak control;Output;outreach;pathogen;Persons;Prevalence;Public Health;Research;Research Personnel;Resources;Risk;Rodent;Rodent Model;Sampling;simulation;social influence;Source;Southwestern United States;Stable Populations;Students;System;Textbooks;Time;tool;trait;trend;undergraduate research experience;Virus;Visual;Visualization;web app;Wild Animals;Zoonoses;zoonotic spillover

PROJECT_TITLE: DMS/NIGMS 2: Spatial, Multi-Host Petri Net Models for Zoonotic Disease Forecasting


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Social Determinants of Health

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative I hypothesize that mentorship is one factor that is more heavily weighted against others in contributing to maintaining diversity. Therefore, my overarching goal of this proposal is to improve my own mentorship approach to incorporate greater cultural awareness in one-on-one mentoring and in laboratory management.

PI_NAMEs: SANDOVAL, DARLEEN A. (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Aggressive behavior;Award;Awareness;Body Weight;Burn injury;burnout;career;Career Choice;college;Communication;Conflict (Psychology);Creativeness;Data;Data Reporting;Dedications;Development;Drops;empowerment;Engineering;Environment;experience;Faculty;Feeling;First Generation College Students;flexibility;Frustration;Gender;glucose metabolism;Goals;graduate student;gut-brain axis;Happiness;high school;improved;innovation;Institution;Investments;Laboratories;Laboratory Research;Latinx;Life;lipid metabolism;marginalization;marginalized community;Mediation;medical schools;Medicine;member;men;Mentors;Mentorship;minority communities;Minority Groups;Personnel Management;Productivity;professor;recruit;Reporting;Research;resilience;Role;Running;satisfaction;school environment;Scientific Advances and Accomplishments;Scientist;Self Efficacy;senior faculty;skills;sobriety;Stress;success;System;Talents;teacher;Teacher Professional Development;Time;Training;undergraduate research;United States National Academy of Sciences;Universities;Voice;Woman;women faculty;Work;Workplace

PROJECT_TITLE: Training for minoritized individuals in gut-brain axis research


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Knowledge of critical interactions among various brain cells is central to understanding the underlying causes of age-related cognitive decline as well as Alzheimer’s dementia. However, accurate identification of molecular changes in  these cells is hard to accomplish using conventional methods. The current project will develop advanced deep learning  methods and techniques to elucidate pathological mechanisms leading to Alzheimer’s disease, which will enable the  identification of novel biomarkers and treatment strategies.

PI_NAMEs: FERNANDEZ-GRANDA, CARLOS ;HERNAEZ, MIKEL ;KALARI, KRISHNA RANI;KANDIMALLA, KARUNYA KUMAR (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: AD transgenic mice;Affect;Age-associated memory impairment;age-related disease;aging brain;Algorithms;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Astrocytes;Autopsy;Brain;brain cell;brain parenchyma;brain tissue;Cell Communication;cell type;Cells;cerebrovascular;Cerebrovascular system;Clinic;Cognitive;cognitive function;Complex;Coupling;Data;data acquisition;deep learning;deep learning model;design;Dropout;Endothelial Cells;Endothelium;flexibility;Freezing;frontier;Functional disorder;Functional Magnetic Resonance Imaging;Gene Expression;Gene Expression Profile;Genes;Harvest;Homeostasis;Image;Impairment;improved;in silico;Individual;Knowledge;Maps;Measures;Methods;Molecular;Molecular Profiling;Mus;Neurons;neurovascular;neurovascular coupling;neurovascular unit;new therapeutic target;normal aging;novel;novel marker;Outcome;Paraffin Embedding;Pathologic;Pathway interactions;Patients;Pericytes;Population;Research Personnel;Sampling;senescence;Sensitivity and Specificity;single-cell RNA sequencing;Techniques;Testing;Tissue Sample;tool;transcriptome sequencing;transcriptomics;treatment strategy

PROJECT_TITLE: CRCNS: Deep Learning to Discover Neurovascular Disruptions in Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-P(50)R]


ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE Type 2 diabetes (T2D) is a complex genetic disease that places substantial burden on the medical and public health systems. We have identified a set of genomic DNA sequence changes in people with T2D that we hypothesize contribute to this disease by changing gene expression patterns and reducing the ability of mitochondria to function in islet cells of the pancreas. In this project, we will complete innovative genomic and cellular analyses, including techniques to 'edit' these genomic DNA sequences, in human islet cells and preclinical mouse models of T2D to test our hypothesis and determine how a targeted subset of genes regulating mitochondrial function contribute to T2D genetic risk and progression.

PI_NAMEs: SOLEIMANPOUR, SCOTT ;STITZEL, MICHAEL LEE (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Address;Affect;Beta Cell;Binding;Bioenergetics;Biological Assay;blood glucose regulation;Cell Line;Cell Physiology;Cell Survival;Cells;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Compensation;Complex;Data;Databases;Defect;Development;diabetes risk;diet-induced obesity;Disease;DNA Binding;DNA copy number;DNA Sequence;Etiology;Failure;Functional disorder;Gene Expression Profile;Genes;Genetic;Genetic Diseases;Genetic Programming;Genetic Risk;Genetic Transcription;genome editing;genome wide association study;genome wide screen;Genomic DNA;genomic locus;Genomics;Glucose;Glucose Intolerance;glycemic control;Health;Health system;Histone Acetylation;Human;Immunodeficient Mouse;impaired glucose tolerance;Impairment;In Vitro;in vivo;innovation;Insulin;Insulin Resistance;insulin secretion;islet;Islet Cell;Islets of Langerhans;Islets of Langerhans Transplantation;Knockout Mice;Knowledge;Link;loss of function;Maps;Medical;Metabolic;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial metabolism;Mitochondrial Proteins;Mitochondrial RNA;Modification;Molecular;Molecular Chaperones;mouse model;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;Nuclear;Pancreas;Pathologic;Patients;Peripheral;Persons;pharmacologic;Phenotype;physiologic model;Physiological;Physiology;pre-clinical;Prediabetes syndrome;prevent;protein folding;Proteins;Public Health;Publishing;Quality Control;Quantitative Trait Loci;Regulatory Element;Reporter Genes;Reporting;risk variant;Role;Single Nucleotide Polymorphism;Structure;Techniques;Testing;Therapeutic;tool;trait;Transcript;transcription factor;transcription regulatory network;Translating;Untranslated RNA;Validation;Variant;Work

PROJECT_TITLE: Type 2 diabetes risk variant effects on mitochondrial (patho)physiology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-L(02)M]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Kidney Disease;Organ Transplantation;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Transplantation

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Kidney transplantation has clear benefits to quality and duration of life over dialysis, yet many patients with end-stage kidney disease face difficulties getting through the transplant referral and evaluation process. The proposed studies will help improve understanding of healthcare system level practices that contribute to inequity in transplant candidate referrals, living donor evaluations and follow-up, and we will identify modifiable social determinants of health that contribute to delays in pediatric kidney transplant evaluation completion. This proposal also provides scientific training for the mentor applicant and her mentees.

PI_NAMEs: AMARAL, SANDRA  (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Address;Advocacy;Algorithms;Award;Black Populations;career;career development;Childhood;cohort;Communities;community based participatory research;Data;Data Collection;Data Sources;Dialysis procedure;Disparity;disparity reduction;Donor Selection;Education;Educational Curriculum;Electronic Health Record;Eligibility Determination;End stage renal failure;Equity;ethnic disparity;Ethnic Origin;Evaluation;Face;Faculty;follow-up;Goals;Health Disparities Research;health disparity;health equity;Health equity research;health inequalities;Health Insurance;Healthcare Systems;Hispanic Populations;Home visitation;implementation science;improved;individual patient;Inequity;Information Systems;Infrastructure;Institutional Racism;Insurance Coverage;Internships;Intervention;Interview;Kidney;Kidney Transplantation;Knowledge;Leadership;Life;Link;Living Donors;marginalized population;Master of Science;Mentors;method development;minority investigator;National Institute of Diabetes and Digestive and Kidney Diseases;national surveillance;Neighborhoods;Nephrology;Not Hispanic or Latino;Outcome;Patients;Pediatrics;Policies;Positioning Attribute;Poverty;Process;programs;Publishing;Race;racial bias;racial disparity;Registries;Renal function;Renal Replacement Therapy;Research;Research Design;Research Methodology;Research Personnel;Research Proposals;Research Support;Residencies;Role;skills;social;social health determinants;sound;Surveys;theories;Time;tool;Training;training opportunity;Translations;Transplant Recipients;transplant registry;Transplantation;Underrepresented Minority;Underserved Population;United States;Waiting Lists;Work

PROJECT_TITLE: Promoting Diversity and Sustainability in the NIDDK-Supported Research Workforce through Mentoring Early Career Investigators: Focus on Health Equity


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Racial and Ethnic Minority Health Research;Stroke

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative A growing number of advanced heart failure patients are supported by the contemporary HeartMate 3 (HM3) continuous-flow (CF) left ventricular assist device (LVAD) around the world, but the optimal blood pressure (BP) range for patients on CF-LVAD support has yet to be fully characterized. Previous studies of patients with older LVAD technology have suggested that elevated BP is associated with stroke and mortality, but minimal data exist regarding the thresholds for maximal and minimal BP for patients supported by contemporary CF-LVADs and the BP goals for women, Blacks, and patients with right heart failure. We propose a prospective study of 200 newly implanted HM3 LVAD outpatients at four different LVAD implantation centers with a structured home and in-clinic BP monitoring protocol to evaluate the association of BP and stroke/death during mean follow-up of two years.

PI_NAMEs: VIDULA, HIMABINDU  (contact)

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: Adverse event;adverse outcome;Anti-Hypertensive Agents;Black Populations;Black race;Blood Pressure;blood pressure control;blood pressure elevation;Blood Pressure Monitors;Brain hemorrhage;Cardiomyopathies;Cessation of life;Cities;Clinic;Clinical;Consensus;Data;Databases;Development;Devices;Doppler Ultrasound;follow-up;Generations;Glomerular Filtration Rate;Goals;Guidelines;Health;health care service utilization;Heart failure;Home;Home Blood Pressure Monitoring;Hypertension;Hypotension;Implant;implantation;improved;indexing;Interagency Registry for Mechanically Assisted Circulatory Support;Ischemic Stroke;Kansas;left ventricular assist device;Long term disability;Magnetism;Measurement;Measures;Mechanics;Medical;Medical center;men;Modality;mortality;novel;Outcome;Outpatients;Patient Outcomes Assessments;Patients;Pharmaceutical Preparations;Population;pressure;Prevention;Prospective Studies;Protocols documentation;Pump;Quality of life;Questionnaires;racial difference;Regimen;Renal function;right ventricular failure;Risk Factors;Sex Differences;Specific qualifier value;Standardization;Stress;Stroke;stroke risk;Structure;Subgroup;Technology;Thrombosis;Time;Universities;Woman

PROJECT_TITLE: Blood Pressure and Outcomes in Contemporary Left Ventricular Assist Device Recipients

STUDY_SECTION: CCHF

STUDY_SECTION_NAME: Cardiac Contractility, Hypertrophy, and Failure Study Section[CCHF]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: SAINT LOUIS

ORG_DEPT: SURGERY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative: Informed consent templates aim to provide clear, transparent information; however, they often include legal jargon, technical wording, and confusing and repetitive sections. The complex consent process can increase disparities in study participation and thus disparities in study benefits. Fortunately, we and colleagues have developed tools and recommendations to improve understanding and adoption of evidence-informed practices for consent in clinical trials. This study will use mixed-methods to adapt, implement and test revised evidence- based consent templates and processes in three different institutions in the U.S.

PI_NAMEs: POLITI, MARY C (contact)

PROGRAM_OFFICER_NAME: ZHANG, XINZHI

PROJECT_TITLE: Sustainable Solutions to Translating Best Practices for Informed Consent

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE CC7 APOLLO Clinical Center Network comprises of all major active kidney transplant centers in Ohio, Michigan, as well as the University of Buffalo, University of Pittsburgh, University of Chicago, and Cleveland Clinic in Florida. To support the APOLLO Consortium’s goal of enrolling all kidney transplant recipients across the United States who received a kidney from an African American donor, as well as all African American living donors, we will continue to leverage the infrastructure and collaboration we built in Phase 1 to ensure that we continue to obtain complete clinical data, urine albumin-to-creatinine ratio, and facilitate return of genetic test results to fulfill the mission of Phase 2. Additionally, we will also continue to enroll living kidney donors and obtain biospecimens for participants enrolled in Phase 1 at the Cleveland Clinic and University of Michigan, according to the goals of the Consortium.

PI_NAMEs: DOSHI, MONA ;POGGIO, EMILIO DANIEL (contact)

PROJECT_TERMS: Acceleration;Acute;Address;African American;African ancestry;Albumins;Allografting;American;Antibodies;APOL1 gene;Apolipoproteins;Bacterial Infections;biobank;Biology;Biopsy;Blood;Chicago;Clinic;clinical center;Clinical Data;cohort;Collaborations;Collection;Communities;Computerized Medical Record;Consent;Cost Savings;Counseling;Creatinine;Data;Databases;digital pathology;Disparity;DNA;Donor person;Education;Eligibility Determination;Enrollment;Ensure;Environmental Risk Factor;ethnic difference;European;Evaluation;Face;Failure;Florida;follow-up;Foundations;gene interaction;Gene Mutation;Genes;Genetic;genetic risk factor;genetic testing;Genotype;Geographic Locations;Goals;graft failure;graft function;Graft Survival;Hand;Health;Health Care Costs;Health system;high risk;HLA Antigens;Hospitals;Immunosuppression;improved;Individual;Infrastructure;Kidney;kidney biopsy;Kidney Failure;Kidney Transplantation;Lesion;Living Donors;living kidney donor;Longterm Follow-up;Measures;Medical;Medical center;member;Michigan;Midwestern United States;Mission;novel;Observational Study;Ohio;Organ;Organ Procurements;Outcome;Participant;participant enrollment;Patients;Phase;Phenotype;Policies;post-transplant;Prevalence;primary outcome;programs;prospective;Proteinuria;Quality of life;racial difference;recruit;Recurrent disease;Registries;Renal function;Reporting;repository;Research;response;Risk;Risk Factors;risk variant;Role;Safety;Saints;secondary outcome;Serum;Site;Slide;Test Result;Time;transplant centers;Transplant Recipients;transplant registry;Transplantation;United Network for Organ Sharing;United States;United States National Institutes of Health;Universities;University Hospitals;Urine;Variant;Virus Diseases;Work

PROJECT_TITLE: 7/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: BOSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: NARRATIVE The proposed research is relevant to public health, and in particular, the mission of the NEI to support research on visual disorders, mechanisms of visual function and preservation of sight, because a greater understanding of mechanisms related to perceptual learning can inform new therapies for treating low vision, which in turn has the potential to benefit millions of individuals suffering from low vision. Declines in vision are particularly common in older adults and thus increasing our understanding of how to create effective means of improving vision is also highly relevant to the mission of the NIA to support research on aging and the health and well-being of older people. In addition to strongly aligning with the missions of the NEI and NIA, the proposed re- search cuts across the bounds of numerous other NIH agencies, including the NCI, NIMH, NIAAA, NINCD, NIDA, NINDS, in that all of these agencies work with populations who could gain direct benefits from successful approaches to utilizing behavioral methods to enhance human well-being and performance.

PI_NAMEs: GREEN, CHRISTOPHER S;SEITZ, AARON R (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: 3-Dimensional;Address;age group;Aging;Assessment tool;Attention;Basic Science;Behavioral;behavioral outcome;Binding;Characteristics;cognitive testing;cognitive training;Computer Models;Computer software;Crossover Design;Cues;Custom;Data;Data Set;design;Devices;Educational workshop;effective intervention;Environment;experience;experimental study;Eye;Failure;Health;Heterogeneity;Human;human subject;improved;Individual;Individual Differences;interest;International;Knowledge;Lead;Learning;learning outcome;Literature;Manufactured Baseball;Measures;Mediating;Mediator;Methods;Mission;Modeling;Modification;multisensory;National Institute of Drug Abuse;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;National Institute on Alcohol Abuse and Alcoholism;Noise;novel;novel therapeutics;older adult;Older Population;Outcome;Outcome Assessment;Outcome Measure;Participant;Perceptual learning;Performance;Personal Satisfaction;Population;preservation;Procedures;Process;Psychology;Psychophysics;Public Health;Publishing;Qualifying;Rehabilitation therapy;Reliability of Results;Research;Research Personnel;Research Support;Running;Sample Size;Sampling;Site;skills;Solid;sound;spatial vision;Specific qualifier value;Specificity;Stimulus;System;Testing;tool;Training;Translating;translational applications;translational approach;translational potential;Translational Research;Translations;United States National Institutes of Health;Vision;Vision Disorders;Visual;Visual impairment;visual performance;Work;young adult

PROJECT_TITLE: Mediators and Moderators of Perceptual Learning


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Dietary Supplements;Genetics;Health Effects of Indoor Air Pollution;Lung;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative This application is to renew our successful participation in the Environmental influences on Children's Health Outcomes (ECHO) Program for an additional seven years (9/2023-8/2030). For this renewal, we will leverage the robust ECHO cohorts with airway-specialized outcomes questionnaires) (MSDP) exposures. (yearly spirometry and twice-yearly respiratory to characterize t he relationships between feta exposure to maternal smoking during pregnancy on airway function and wheeze during childhood as modified by multi-factorial prenatal and postnatal W l e will also leverage ECHO Cohort Protocol 3.0 core data elements to characterize the epigenetic signatures in placenta and offspring associated with MSDP, and examine their additive predictive value relative to additional prenatal and postnatal exposures.

PI_NAMEs: MCEVOY, CYNTHIA T (contact);SPINDEL, ELIOT R

PROGRAM_OFFICER_NAME: LAESSIG, SUSAN ALISON

PROJECT_TERMS: 21 year old;5 year old;Adult;Affect;Air Pollution;Airway Disease;American;Antismoking;Area;Ascorbic Acid;Asthma;Biological Markers;Birth;Cannabis;Child;Child Health;Childhood;Clinical;cohort;Collaborations;comorbidity;Conceptions;Consent;Data;Data Element;data harmonization;Data Set;Development;DNA Methylation;emerging adult;Environmental Exposure;Epigenetic Process;Exposure to;Family;fetal;Fetal Lung;follow-up;Genetic;Goals;Habits;Health;Health Care Costs;Impairment;improved;Inequity;Infant;Investigation;late life;Lead;Life;Link;Longitudinal Studies;lung development;Lung Diseases;lung health;marijuana use;marijuana use in pregnancy;maternal cigarette smoking;maternal vaping;Measures;Mediating;Medical;medical specialties;methylation biomarker;Mothers;Nasal Epithelium;neglect;novel;offspring;Outcome;Outcome Study;Participant;Pathway interactions;Phase;Placenta;Population Heterogeneity;postnatal;postnatal period;Predictive Value;Pregnancy;pregnant;prenatal;prenatal cigarette smoking;prenatal exposure;programs;Protocols documentation;Proxy;pulmonary function;Questionnaires;respiratory;Respiratory Disease;respiratory health;respiratory morbidity;Respiratory physiology;Risk;Risk Factors;Smoking;smoking during pregnancy;social;Specificity;Spirometry;success;Supplementation;synergism;Time;Tobacco use;vaping;Wheezing;Woman

PROJECT_TITLE: Continued follow-up of the Vitamin C and Smoking in Pregnancy (VCSIP) cohorts through the ECHO consortium, focus on Echo-wide protocols, respiratory outcomes, airway function, and epigenetic changes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-S(50)R]


NIH_SPENDING_CATS: Clinical Research;Disability Research;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD)

ORG_CITY: SANTA CRUZ

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: Project Narrative Tactile and multimodal vibrational/audio maps can be very useful for blind individuals who want to acquire spatial knowledge of the environment before or during a trip. While systems exist for the systematic production of outdoors tactile maps, indoor tactile maps are normally created by professionals using ad-hoc techniques. The proposed work will develop and experiment with new technology for the semi-automatic creation of indoor tactile maps, leading to a map production service for all interested stakeholders managed by our partner institution, the Vista Center for the Blind of Palo Alto, CA.

PI_NAMEs: GIUDICE, NICHOLAS A;MANDUCHI, ROBERTO  (contact)

PROJECT_TERMS: 3-Dimensional;Acoustics;Address;Area;Awareness;blind;Cellular Phone;Cognition;Cognitive;Collaborations;Communities;computer science;Computer software;Confusion;Dangerousness;Data;Data Set;design;Destinations;Diffusion;Educational process of instructing;effectiveness evaluation;Engineering;Environment;Evaluation;experimental study;Floor;Generations;Geographic Information Systems;Home;human subject;Image;Indoor environment;Information Sciences;Institution;interest;Knowledge;Learning;Location;Maine;Maps;Modernization;multimodality;Navigation System;new technology;open source;Persons;Production;Published Comment;Reporting;Research;Research Activity;research and development;Route;San Francisco;Schools;Semantics;Series;Services;skills;smartphone application;Specific qualifier value;stem;Structure;Study Subject;System;Tactile;Techniques;technological innovation;Technology;tool;Training;Twin Studies;usability;vector;Vision;Visual impairment;visual map;Visually Impaired Persons;web app;Work

PROJECT_TITLE: Maps as a service: A systematic approach to the production of tactile and audio/vibrational maps for visually impaired users

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-P(81)S]


NIH_SPENDING_CATS: Asthma;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Microbiome;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Asthma is a complex condition with both genetic and environmental contributors to disease inception. Leveraging the large, diverse ECHO cohort, this proposal investigates how neighborhood (air pollution, nearby green space) and the individual (microbiome) level exposures alter DNA methylation and transcriptional responses at the epithelial barrier to promote asthma and asthma related disparities. These studies will help identify non-invasive biomarkers and define actionable exposures for intervention.

PI_NAMEs: SINGH, ANNE MARIE  (contact)

PROGRAM_OFFICER_NAME: MASH, CLAY

PROJECT_TERMS: Affect;Age;Air Pollution;airway epithelium;Allergic;Allergic Disease;allergic response;Asthma;asthma exacerbation;asthma prevention;Atopic Dermatitis;Bacteria;bacterial community;Biological Markers;Biology;Birth;Calendar;Censuses;Characteristics;Child;Childhood;Childhood Asthma;Clinical;cohort;Communities;Complex;Conceptions;Data;data harmonization;Development;Diagnosis;Disease;Disparity;disparity reduction;DNA Methylation;early life exposure;Enrollment;Environment;Environmental Exposure;Environmental Health;Environmental Risk Factor;Epigenetic Process;Epithelial Cells;Epithelium;Ethnic Origin;Exposure to;follow-up;Functional disorder;Funding;gene environment interaction;Gene Expression;Gene Expression Profile;Genetic;Genetic Risk;Genetic Transcription;Geography;Goals;Green space;health disparity;Health Promotion;Household;Human;Hypersensitivity;immune activation;Incidence;Individual;Individual Adjustment;infancy;Infant;Inflammation;insight;Intervention;Life;Link;Low income;Mediating;microbial colonization;microbiome;Modification;Molecular;Molecular Target;multidisciplinary;multiple omics;Nasal Epithelium;Neighborhoods;Neonatal;Newborn Infant;Nose;Participant;Pathogenesis;Pathogenicity;Pathway interactions;Pattern;Population Density;Positioning Attribute;Pregnancy;Pregnant Women;prenatal;Prevalence;Prevention;Prevention strategy;programs;Protocols documentation;Publishing;Race;recruit;Recurrence;respiratory;response;Risk;sex;Skin;Skin colonization;skin microbiome;social health determinants;Structure;Swab;Technology;Testing;transcriptomics;treatment strategy;Wheezing;Woman

PROJECT_TITLE: Childhood Allergy and the NeOnatal Environment (CANOE) ECHO Pediatric Follow-Up and New Enrollment


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Hematology;Lung;Prevention;Pulmonary Hypertension

ORG_CITY: DURHAM

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PUBLIC HEALTH RELEVANCE STATEMENT: The proposed work seeks to advance MRI methods to visualize cardiopulmonary function, non-invasively and 3-dimensionally. Here we apply these techniques before and after interventions to help position these methods for use in comprehensive assessment of patients who experience shortness of breath (dyspnea).

PI_NAMEs: DRIEHUYS, BASTIAAN  (contact)

PROGRAM_OFFICER_NAME: GAN, WEINIU

PROJECT_TERMS: 3-Dimensional;Acceleration;Acute;Address;Affect;Aftercare;Alveolar;Anemia;Anticoagulation;base;Biological Markers;Biomedical Technology;Blood capillaries;Blood Component Removal;Blood donor;Blood flow;Blood Vessels;Carbon Monoxide;Cardiac;Cardiopulmonary;Caring;Chemicals;Chronic;chronic pain;chronic thromboembolic pulmonary hypertension;Clinical assessments;clinical care;clinical decision-making;Coagulation Process;comparative;cost;deconditioning;Defect;Development;Diagnosis;Diagnostic tests;Diffuse;Diffusion;Disabling;Disease;Disease Progression;Distal;Distress;Dizziness;Dyspnea;Early Diagnosis;Emergency Care;Emergency department visit;Erythrocytes;Etiology;Evaluation;Exercise Test;Exhibits;experience;frailty;Gases;Goals;Health;Hemoglobin;Image;improved;innovation;insight;interstitial;Interstitial Lung Diseases;Intervention;Long COVID;Lung;Lung Diseases;lung hypoxia;lung imaging;Magnetic Resonance Imaging;Measurable;Measures;medical attention;Membrane;Methods;Mission;Modeling;Multi-Institutional Clinical Trial;Neuromuscular Diseases;new technology;Operative Surgical Procedures;Outcome;Oxygen;Oxygen Therapy Care;oxygen transport;patient population;Patients;Physiological;Population;Positioning Attribute;Prevalence;public health relevance;Pulmonary Embolism;pulmonary function;Pulmonary function tests;Pulmonary Gas Exchange;Pulmonary Hypertension;Quality of life;reconstruction;Research;Research Personnel;Resources;response biomarker;Selection for Treatments;Shortness of Breath;Signal Transduction;Solubility;Symptoms;Techniques;Technology;Testing;Therapeutic;Therapeutic Trials;Time;Tissues;tool;trait;Transfusion;United States National Institutes of Health;uptake;ventilation;Visualization;Work;X-Ray Computed Tomography

PROJECT_TITLE: Early Detection of Changes in Pulmonary Gas Exchange by Hyperpolarized  Xe MRI

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Cocaine;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Methamphetamine;Opioids;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE. The goal of this proposal is to develop a better understanding of social, cultural, structural and other factors that drive health disparities for underserved racial/ethnic and marginalized populations at the intersection of HIV and substance use, particularly methamphetamine, cocaine/crack, and illicit opioid use. We work with community partners and other end-users to examine disparities in substance use patterns of use, treatment, overdoses, and HIV care and comorbidities among marginalized populations of people with HIV including not only racial/ethnic populations, but also transgender people, those with unstable housing, those recently incarcerated, and others. This study will inform future research, interventions, and assist end-users within our community partnerships in tailoring future substance use treatment programs to the unique needs of multidimensional identities in order to reduce disparities among populations severely affected by inequities at the intersection of HIV care and substance use treatment.

PI_NAMEs: CRANE, HEIDI M. (contact);FREDERICKSEN, ROB ;HAHN, ANDREW WILLIAM

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: Abbreviations;Acquired Immunodeficiency Syndrome;Address;adjudication;adverse childhood events;Affect;Age related comorbidities;Aging;Alcohol consumption;Alcohols;Area;asexual;Behavior;Behavioral;Black, Indigenous, People of Color;Cannabis;Caring;Chronic Kidney Failure;Clinical;Clinical Data;Cocaine;cocaine use;Cocaine Users;cohort;community collaboration;community partners;community partnership;comorbidity;Continuity of Patient Care;Critical Thinking;Data;Diabetes Mellitus;Dimensions;Discrimination;Disparity;disparity reduction;Drug usage;Epidemic;Equity;ethnic identity;Ethnic Origin;Ethnic Population;Evaluation;experience;frailty;Frequencies;Future;Gender;Gender Identity;General Population;Goals;health disparity;health inequalities;health related quality of life;Health Services Accessibility;High Prevalence;Hispanic;HIV;Housing;housing instability;Hypertension;illicit opioid;Imprisonment;indexing;Individual;Inequity;Infrastructure;insight;instrument;Intersex;Intervention;intimate partner violence;Knowledge;Latinx;Lesbian Gay Bisexual Transgender Queer Questioning;marginalized population;Measures;medication compliance;Mental Health;Methamphetamine;methamphetamine use;multiple drug use;Myocardial Infarction;Naloxone;Nicotine;Opioid;opioid epidemic;opioid use;Outcome;Outcome Assessment;outcome disparities;Overdose;overdose death;overdose risk;Patient Outcomes Assessments;Pattern;perceived discrimination;Persons;Pharmaceutical Preparations;PhenX Toolkit;Population;Population Heterogeneity;Poverty;Prevention;Prevention approach;protective factors;psychosocial;Psychosocial Factor;Race;racial difference;racial population;Recommendation;Research;Resources;Risk Behaviors;Risk Factors;Role;Severities;Sex Orientation;social;social factors;social health determinants;social stigma;social structure;Social support;sociodemographics;spelling;Stimulant;Stroke;structural determinants;substance use;Substance Use Disorder;substance use prevention;substance use treatment;System;Time;transgender;treatment and outcome;Treatment outcome;treatment program;treatment response;treatment strategy;Underserved Population;United States;uptake;Viral;Work

PROJECT_TITLE: Understanding Health Inequities at the Intersection of the HIV and substance use epidemics across racial/ethnic and other underserved populations


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Infectious Diseases;Prevention

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative Reducing the spread of infectious diseases through environmental media (air, water, soil, food, surfaces, etc.) requires contributions from clinicians, epidemiologists, microbiologists, engineers, public health professionals and other disciplines to perform rigorous risk analysis. However, quantitative microbial risk assessment methodology is not widely understood though it is recommended by the World Health Organization and various U.S. agencies for supporting intervention and prevention strategies as risk based decisions. The QMRA IV education and mentoring program will equip professionals across biomedical disciplines with sustained academic and instrumental mentoring to conduct research and make decisions to minimize risks from infectious disease.

PI_NAMEs: MITCHELL, JADE  (contact);WEIR, MARK HOWARD

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Address;Air;Behavioral;Biological Process;Biology;biomedical scientist;career;Collaborations;Communicable Diseases;Communication;Communities;Complex;computational platform;computerized tools;Data;data integration;Data Set;Decision Making;Decontamination;Development;Discipline;Disease;E-learning;Education;Emergency response;Engineering;Enrollment;Environment;Environmental Health;Epidemiologist;Equilibrium;Etiology;Evaluation;evidence base;Exclusion;Exposure to;first responder;Food;foodborne illness;Funding;Future;global health;Goals;Health;Health Policy;Health Professional;Human;improved;Industrial Health;Infection;Infectious Agent;Intervention;knowledge integration;Lead;Learning;learning materials;mathematical methods;Mathematics;Measures;medical countermeasure;member;Mentors;Methodology;microbial;Modeling;multidisciplinary;Outcome;outreach;Participant;pathogenic microbe;Population;Positioning Attribute;Prevention strategy;Probability;Process;programs;Public Health;Recommendation;Research;Research Personnel;Rest;Risk;Risk Assessment;Risk Management;risk minimization;Science;Scientist;senior faculty;skills;Soil;Specialist;statistics;Surface;System;tool;Training;training opportunity;Translational Research;Trust;Uncertainty;United States National Institutes of Health;Water;waterborne illness;Work;World Health Organization

PROJECT_TITLE: QMRA IV- Quantitative Microbial Risk Assessment Interdisciplinary Vehicle: Addressing Emerging Global Health Risks


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Estrogen;Mental Health;Pediatric;Substance Misuse;Underage Drinking;Women's Health Research

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

PHR: The proposed research aims to determine the behavioral mechanisms by which ovulatory surges in estradiol increase alcohol use in young women by increasing their sensitivity to the rewarding and disinhibiting effects of alcohol that promote patterns of binge drinking. The research will provide important new information on how certain hormonal phases, such as those linked with estradiol surges, can challenge relapse prevention and other alcohol treatment efforts in young women with alcohol use disorders.

PI_NAMEs: FILLMORE, MARK T (contact);MARTEL, MICHELLE M

PROGRAM_OFFICER_NAME: AKBAR, MOHAMMED

PROJECT_TERMS: abuse liability;Acute;Adult women;Adverse effects;Affect;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol craving;alcohol effect;alcohol sensitivity;alcohol use disorder;Alcohols;Animal Experimentation;Area;Behavior;Behavioral;Behavioral Mechanisms;binge drinking;Clinical assessments;Consumption;craving;Data;Data Reporting;Disinhibition;Dose;drinking behavior;Estradiol;Estrogens;Exhibits;Female;Grain;Health;Heavy Drinking;High Risk Woman;Hormonal;Hormones;Impulsivity;Intervention;Investigation;Laboratories;Link;Liver Cirrhosis;Longitudinal Studies;Maintenance;Measures;men;Menstrual cycle;neurobehavioral;Neurobiology;Oral Contraceptives;Organ;Ovarian hormone;Ovulation;Ovulation Prediction;Patient Self-Report;Pattern;Periodicity;personalized intervention;Phase;Physiological;Placebos;Progesterone;proliferative phase Menstrual cycle;Puberty;Public Health;Recording of previous events;Relapse;relapse prevention;reproductive;Research;Rewards;Risk;Risk Taking;Saliva;Sampling;Sex Behavior;Sex Differences;sexual assault;Substance abuse problem;Testing;Theoretical model;theories;university student;Visit;Woman;women's treatment;Work;young adult;young woman

PROJECT_TITLE: Estradiol Effects on Behavioral and Reward Sensitivity to Alcohol across the Menstrual Cycle

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The goal of this application is to continue a highly successful training program that has produced diverse and broadly trained scientists over the last 15 years. This highly trained workforce of basic scientists and physician/scientists will be at the forefront of cancer research in the coming decades and will assume leadership roles to produce the scientific data to improve diagnosis, survival rates and quality of life of individuals with cancer.

PI_NAMEs: GOGA, ANDREI  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Malignant Neoplasms;Molecular

PROJECT_TITLE: Molecular and Cellular Mechanisms in Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Eye Disease and Disorders of Vision;Physical Injury - Accidents and Adverse Effects;Wound Healing and Care

PHR: Project Narrative Eye is the most sensitive organ to mustard vesicant nitrogen mustard (NM) and sulfur mustard (SM) exposure with devastating short- and long-term injuries; however, no effective treatments are available. Novel studies under this grant will investigate the time-dependent distribution of NM exposure scenarios in the eye tissues and demonstrate how localized concentrations in cornea are tied to injury mechanisms and toxic responses using in vivo and in silico rabbit ocular models. This study could serve as a more efficient and potentially more insightful novel approach to evaluate toxicity mechanisms underlying the mustard vesicant ocular pathology, and in the identification of therapeutic targets to counter acute and long-term ocular complications from their exposure.

PI_NAMEs: GERMAN, CARRIE ;TEWARI-SINGH, NEERA  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Acute;Address;adduct;Affect;analog;Animal Testing;Animals;Aqueous Humor;Biochemical;Bioinformatics;Biological;Biological Markers;biomarker evaluation;Blindness;Bulla;chemical threat;Clinical;Computer Models;conjunctiva;Cornea;Corneal Injury;corneal repair;cost;Data;design;Development;DNA;Dose;effective therapy;Evaluation;experimental study;Eye;Eye Injuries;Future;Grant;improved;in silico;in vivo;in vivo evaluation;Inflammation;injured;Injury;injury and repair;Keratopathy;Knowledge;Laboratories;Liquid substance;Mass Spectrum Analysis;Mechlorethamine;Minor;Modeling;Molecular;Mustard;Mustard Gas;nerve agent;novel;novel strategies;Ocular Pathology;Organ;Oryctolagus cuniculus;Pathologic;Pathology;Pathway interactions;Penetration;Phase;Process;Publishing;Recording of previous events;repaired;Reporting;Research;response;response biomarker;Retina;retinal toxicity;Severities;Study models;Symptoms;Syria;Terrorism;Testing;Therapeutic;therapeutic evaluation;therapeutic target;Time;Tissues;Toxic effect;Toxicokinetics;transcriptome;transcriptome sequencing;transcriptomics;Translating;Translations;treatment strategy;Validation;Vesicants;Visual impairment;Vitreous humor;wound healing

PROJECT_TITLE: Understanding Mustard Vesicants Distribution and Toxicity in the Eye Using In Vivo and In Silico Models


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Lung;Neonatal Respiratory Distress;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Social Determinants of Health

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: PROJECT NARRATIVE The Darbepoetin Kindergarten Development Study (Darbe-KIDS) proposes to follow children who participated in the NHLBI-funded multicenter “Darbepoetin Trial to Improve Red Cell Mass and Neurodevelopment in Preterms” (Darbe Trial) at preschool and school age, with the goal of evaluating the effects of darbepoetin on neurodevelopment in children born preterm. Darbe-KIDS will be led by a highly collaborative, interdisciplinary multi-PI team with extensive relevant experience studying the impacts of erythropoiesis stimulating agents in preterm infants and a long history of successful collaborations in conducting high-quality developmental follow- up through school age in large cohorts of high-risk infants. The results of Darbe-KIDS will be essential for determining whether darbepoetin becomes a routine therapy for neuroprotection in this vulnerable population.

PI_NAMEs: BANN, CARLA M (contact);DEMAURO, SARA BONAMO;LOWE, JEAN ;MERHAR, STEPHANIE L;OHLS, ROBIN K

PROGRAM_OFFICER_NAME: FRANK, DANIEL J

PROJECT_TERMS: 2 year old;4 year old;Academic achievement;Academic skills;Adopted;Affect;Aftercare;Age;Animal Model;Behavior;Behavior assessment;behavioral outcome;biological sex;Birth;Brain;Caregivers;Child;Child Behavior Checklist;Childhood;Clinical Data;clinical research site;Cognition;Cognitive;cognitive function;cognitive testing;cohort;Collaborations;Data;Development;Dimensions;early childhood;emotional functioning;Enrollment;Erythropoiesis;Evaluation;executive function;experience;Exposure to;extreme prematurity;Family;follow-up;Funding;Goals;high risk;high risk infant;Human;Impaired cognition;improved;improved outcome;Infant;Infrastructure;insight;interest;kindergarten;Masks;Mediating;Mediator;middle childhood;Motor;motor impairment;Motor Skills;Movement;Multicenter Neonatal Research Network;multidisciplinary;National Heart, Lung, and Blood Institute;Nature;neonatal exposure;Neonatal Intensive Care Units;neurodevelopment;neuroprotection;Neuroprotective Agents;neurorestoration;novel;Nursery Schools;Outcome;Outcome Assessment;Parents;Participant;participant enrollment;peer;phonology;Placebos;pre-clinical;Premature Infant;Preschool Child;Randomized;randomized trial;Recording of previous events;Red Cell Mass result;Reporting;Research;Research Personnel;Role;routine therapy;School-Age Population;Schools;Site;social skills;Socioeconomic Status;teacher;Testing;Time;Toddler;United States;United States National Institutes of Health;Very Low Birth Weight Infant;Vulnerable Populations

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: PHYSIOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Narrative A major challenge in the study of short-term memory is to determine how the interactions among functionally, genetically, and anatomically diverse classes of neurons give rise to the persistent patterns of neural activity underlying memory storage and function. We address this challenge by combining synapse resolution anatomy and circuit-wide, cellular resolution recordings and perturbations of neural activity into a biologically realistic model that enables us to infer the physiological interactions underlying short-term memory function.

PI_NAMEs: AKSAY, EMRE R (contact);GOLDMAN, MARK S

PROJECT_TERMS: 3-Dimensional;Address;Anatomy;Behavior;behavior change;Biological;Biological Models;Brain region;Calcium;cell type;Cells;Conceptions;Couples;Coupling;Data;Decision Making;Dependence;Disease;Disparate;Exhibits;Experimental Designs;experimental study;Eye;Eye Movements;eye velocity;flexibility;Foundations;Functional Imaging;Future;gaze;Genotype;Heterogeneity;Image;imaging study;in silico;Individual;insight;Location;Maps;Mathematics;Measurement;Memory;Modeling;motor control;network models;neural;neural patterning;Neurons;oculomotor;optical imaging;optogenetics;Pattern;Physiological;Play;Population;Positioning Attribute;postsynaptic;predictive modeling;Preparation;Property;reconstruction;Recurrence;Resolution;response;Role;Short-Term Memory;Signal Transduction;simulation;Specificity;Speed;Stimulus;Synapses;System;Testing;Theoretical model;Theoretical Studies;theories;Three-Dimensional Imaging;Time;Transgenic Organisms;treatment strategy;two-photon;Vision;Visual;Visual impairment;Work;Zebrafish

PROJECT_TITLE: Circuit Mechanisms Underlying Persistent Activity in a Neural Integrator

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention

ORG_DEPT: BIOCHEMISTRY

PHR: PROJECT NARRATIVE Severe respiratory viral infections, including influenza A viruses, are leading causes of lung inflammation and pathology. In severe cases of influenza, lung inflammation and pathology can persist after clearance of the virus and lead to long-term respiratory symptoms, referred to as post-viral lung disease (PVLD). This project seeks to define the role of lung fibroblasts in driving PVLD and determine if these cells are effective therapeutic targets to prevent or reverse this disease.

PI_NAMEs: BOYD, DAVID FIELDING (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Acute;acute infection;Acute Respiratory Distress Syndrome;ADAMTS;Address;Alveolar;Alveolar Cell;alveolar epithelium;Apoptosis;Automobile Driving;Cell Death;cell type;Cells;Cellular biology;Cessation of life;Chronic;Chronic Obstructive Pulmonary Disease;chronic respiratory disease;clinically relevant;Coculture Techniques;comorbidity;dark matter;Data;debilitating symptom;Disease;epithelial repair;epithelial stem cell;experience;Failure;Fibroblasts;Flow Cytometry;healing;high dimensionality;Hospitals;idiopathic pulmonary fibrosis;Immune;immune cell infiltrate;immune modulating agents;Immunology;immunopathology;Impairment;improved;in vivo;Infection;Inflammation;Inflammation Mediators;Inflammatory;Influenza;Influenza A virus;influenza infection;influenza virus strain;inhibitor;Intervention;Label;Length of Stay;Link;Long-Term Effects;Lung;Lung Diseases;lung injury;lung repair;Mediating;Mediator;Modeling;Molecular;mouse model;Nature;novel therapeutics;Pathogenesis;Pathology;Pathway interactions;Patients;Peptide Hydrolases;pharmacologic;Phase;prevent;Prevention;Production;pulmonary function;Pulmonary Inflammation;Pulmonary Pathology;Recovery;repaired;Research;respiratory;Respiratory Signs and Symptoms;restoration;Role;Severity of illness;Signal Transduction;small molecule;Source;Stromal Cells;Structure of parenchyma of lung;Survivors;System;targeted treatment;Testing;Therapeutic;therapeutic target;therapeutically effective;Tissues;transcriptomics;Viral;Viral Respiratory Tract Infection;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Understanding and targeting fibroblast activation in influenza-triggered lung inflammation and post-viral disease

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Aging;Brain Disorders;Genetics;Human Genome;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE The most common cause of idiopathic and familial Parkinson’s disease, an adult onset movement neurodegenerative disorder, are mutations in leucine-rich repeat kinase 2 (LRRK2). The overarching goal of this proposal is to understand the underlying mechanisms of mitochondrial DNA damage, a shared phenotype between LRRK2-associated and idiopathic PD. It is hoped that cellular pathways involved in maintaining mitochondrial genome integrity will reveal potential new therapeutic strategies to treat this devastating disease.

PI_NAMEs: SANDERS, LAURIE H (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Address;Adult;age related neurodegeneration;alpha synuclein;ataxia telangiectasia mutated protein;ATM activation;ATM function;Automobile Driving;Autopsy;Biochemical;Bioenergetics;Biological;brain tissue;Cell Death;Data;Defect;Dependence;Development;Disease;disease model;Disease Progression;DNA Damage;DNA lesion;DNA Repair;DNA Sequence Alteration;dopaminergic neuron;Dose;Etiology;Exposure to;Fibroblasts;Foundations;Functional disorder;Genetic;genome integrity;Goals;Health;Homeostasis;Human;human induced pluripotent stem cells;Idiopathic Parkinson Disease;Impairment;in vivo;induced pluripotent stem cell;insight;Investigation;kinase inhibitor;Knowledge;Link;LRRK2 gene;Mediating;member;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial genome;Modeling;Molecular;Movement;Movement Disorders;Mus;mutant;Mutation;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neurons;neuroprotection;neurotoxic;novel;novel therapeutic intervention;Outcome;Parkinson Disease;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Persons;pharmacologic;Phenotype;Phosphorylation;Phosphotransferases;Preclinical Testing;Proteins;Publishing;Reactive Oxygen Species;repaired;Reporting;response;Role;Signal Transduction;Techniques;Testing;Therapeutic;therapeutic target;toxicant;trafficking;Translating

PROJECT_TITLE: Mechanisms of mitochondrial genome integrity in familial and idiopathic Parkinson's disease

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: LA JOLLA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: This proposed development of vibrational sum frequency generation microscopy, in the short term, will spatially resolve collagen tissues with chemical structure and molecular interaction information in a complicated environment. Machine learning and simulation approaches will be employed to build a data base to convert hyperspectral images of collagen into a spatial map with microscopic structures and molecular interaction information. In the long term, the fundamental biochemical knowledge learned from this development will lay foundations for rationally design biomedical approaches to monitor and control pericellular spaces and its interaction with cells, and further advance treatment to diseases related to it.

PI_NAMEs: XIONG, WEI  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 3-Dimensional;Architecture;Binding;Biochemical;Biocompatible Materials;Biological;biophysical techniques;Biophysics;Cells;Chemical Structure;Chemicals;Collagen;Collagen Fiber;Collagen Fibril;Collagen Type I;Complex;Data;Databases;Development;Disease;Environment;Fiber;Fibrosis;Foundations;Frequencies;Future;Generations;Goals;human tissue;Image;image reconstruction;Imaging Techniques;In Vitro;insight;Knowledge;Label;Learning;Location;Machine Learning;Maps;Microscopic;Microscopy;Molecular;molecular imaging;Molecular Profiling;Monitor;Morphology;National Institute of General Medical Sciences;new technology;Peptides;Physiological;Proteins;rational design;Research;self assembly;simulation;Structure;Sum;System;Techniques;Tissue Engineering;Tissues;Water

PROJECT_TITLE: Imaging Molecular Level Details of Collagen Fibers by VSFG Microscopy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-N(55)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Eye Disease and Disorders of Vision;Genetics;Physical Injury - Accidents and Adverse Effects

ORG_NAME: TUFTS MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE A high-consequence chemical emergency is a major public health concern demanding development of critical medical MCMs against chemical threats. The eyes are the most frequent route of toxic exposure. Results of our studies will provide new knowledge about mitochondrial mechanisms of OcS damage caused by exposure to mustard compounds and establish rationale for a potentially paradigm-shifting therapeutic that targets mitochondrial bioenergetics. Page 1 of 1

PI_NAMEs: FINI, M ELIZABETH  (contact)

PROJECT_TERMS: Abbreviations;Alkylation;analog;Attenuated;Bioenergetics;Cell Culture Techniques;cell injury;Cells;chemical disaster;chemical threat;Chemical Warfare;Chloroquine;Chronic;Complex;Consumption;Cornea;corneal epithelium;Cysteine;Cytoprotection;Data;Development;Dimensions;Doxycycline;Dynamin;Electron Transport;Ensure;Epithelial Cells;Epithelium;Exposure to;Eye;eye dryness;Follow-Up Studies;Gene Expression Profile;Genes;Homeostasis;Human;Hydrogen Peroxide;Image;In Vitro;in vivo;inhibitor;innovation;insight;Knowledge;limbal;Mechlorethamine;Medical;medical countermeasure;Methods;Mitochondria;mitochondrial permeability transition pore;mitochondrial therapeutics;Modeling;Molecular;mouse model;Mus;Mustard;Mustard Compounds;Mustard Gas;Names;Nomenclature;novel;ocular surface;Oxidative Stress;Oxidative Stress Induction;Pathologic;Pathology;Pathway interactions;Phase;Phenotype;Play;prevent;Production;Protein Family;Proteins;Public Health;Reactive Oxygen Species;Reporter;Reporter Genes;Reporting;response;response to injury;Route;single-cell RNA sequencing;small molecule;small molecule inhibitor;Stress;synergism;Techniques;tert-Butylhydroperoxide;Tissues;Toxic effect;Toxicant exposure;transcriptome sequencing;Transgenic Organisms;Validation;Vesicants

PROJECT_TITLE: Mitochondria and Mustard Damage at the Ocular Surface


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lupus;Networking and Information Technology R&D (NITRD);Prevention;Vaccine Related

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE The proposed research will develop widely-applicable computational methods to make statistical inferences about migration of B cells between tissues and differentiation of B cells into cellular subtypes. These methods will significantly expand the ability of scientists to study these dynamic processes in humans. Working closely with experimental collaborators, we will validate and then apply these methods to several biological systems including vaccination and autoimmunity, in both human and murine model systems.

PI_NAMEs: HOEHN, KENNETH  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: 2019-nCoV;adaptive immune response;Adult;Affinity;age related;Antibody Affinity;Antibody-Producing Cells;Antigens;Asthma;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmune Diseases of the Nervous System;Autoimmunity;B cell differentiation;B-Cell Antigen Receptor;B-Cell Development;B-cell receptor repertoire sequencing;B-Lymphocytes;Binding;Biological Models;biological systems;Biology;Blood;Blood specimen;Bone Marrow;Cell Differentiation process;Cell Lineage;cell motility;cell type;Cells;Cellular biology;Complex;computer framework;Computer software;Computing Methodologies;COVID-19 pandemic;Data;data exchange;Development;Disease;DNA Sequence;effectiveness evaluation;Epidemic;Event;Evolution;experimental analysis;flexibility;Foundations;Future;Genetic;Geography;Goals;HIV;Human;human model;Immune response;Immunity;Immunoglobulin Somatic Hypermutation;Immunologist;Immunology;Individual;Infection;Influenza vaccination;influenza virus vaccine;Knowledge;Lupus;lymph nodes;Maps;Measures;Mediating;Medical;medical schools;Memory;method development;Methods;migration;model design;Modeling;Modeling of Cellular Pathways;mouse model;Multiple Sclerosis;Mus;Mutation;Myasthenia Gravis;neurological pathology;Neuromyelitis Optica;novel;Outcome;pathogen;Pathogenicity;Pathology;Pathway interactions;Patients;Pattern;Phase;Phylogenetic Analysis;plasma cell differentiation;Plasma Cells;Plasmablast;Play;Population;Process;Recording of previous events;Research;Research Personnel;response;RNA Sequences;Role;Scientist;self-renewal;Sequence Analysis;simulation;single cell analysis;single-cell RNA sequencing;software development;Source;Structure of germinal center of lymph node;System;Systemic Lupus Erythematosus;targeted treatment;Technology;Testing;Time;Tissue Sample;Tissues;tool;Training;Translating;Trees;Vaccination;vaccination strategy;vaccine response;Vaccines;Variant;Viral;Virus;Work

PROJECT_TITLE: Computational mapping of human B cell migration and differentiation pathways

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Cystic Fibrosis;Dietary Supplements;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Nutrition;Orphan Drug;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative This proposal aims to enable precision nutrition by creating a wearable sweat bioanalytical technology— equipped with autonomous sweat secretion modulation, biofluid management, and analysis capabilities—that can be scaled across the general population to non-invasively track the diurnal profiles of a panel of putative circulating nutrients and biomarkers. By deploying this technology in clinical studies (with a particular focus on cystic fibrosis, the most common inherited multisystemic disorder), we will study and establish the correlation of the sweat readings to the circulating analytes and in response to nutritional interventions. This technology will provide a comprehensive and physiologically rich view of the individuals’ well-being/disease and nutritional status, rendering a personalized solution for effective treatment and nutritional support.

PI_NAMEs: EMAMINEJAD, SAM  (contact);MILLA, CARLOS ;SANKARARAMAN, SRIRAM

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Algorithms;beta-Hydroxybutyrate;Biological Markers;Blood;Chlorides;Clinical;Clinical Research;cofactor;cohort;Complex;Cystic Fibrosis;cystic fibrosis patients;Data Analytics;Data Set;Dedications;Development;Devices;Dietary Intervention;dietary supplements;Disease;Disease Management;effective therapy;Engineering;experimental study;fabrication;General Population;Glucose;Hour;human subject;In Situ;Individual;Influentials;Inherited;Intake;Iontophoresis;Machine Learning;machine learning algorithm;Measures;Metabolic;Methodology;Microfluidics;microsensor;Mission;Modality;Modeling;Monitor;multidisciplinary;Nutrient;Nutritional status;Nutritional Support;operation;Periodicals;Personal Satisfaction;personalized medicine;Phase;Physiological;Physiology;Positioning Attribute;precision nutrition;predictive modeling;Randomized;recruit;remote patient monitoring;response;Sampling;sensor;Sodium;Study Subject;success;Sweat Glands;Sweat test;System;targeted biomarker;Technology;translational applications;Triglycerides;Validation;wearable device;wearable monitor;wearable platform;Work

PROJECT_TITLE: An Autonomous, Non-invasive, and Bioanalytics-enabled Wearable Platform for Precision Nutrition and Personalized Medicine


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: Los Angeles

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Osteoarthritis (OA) is the most common form of degenerative joint disease affecting millions of people worldwide. In this proposal, we will generate new mechanistic understanding of distinct signaling pathways and determine whether manipulation of these pathways can protect against OA progression in mouse models. Given the fact that there are currently no disease modifying therapies available for OA, this proposal will shed light on our understanding of chondroprotective mechanisms and accelerate the diagnosis and treatment of human OA.

PI_NAMEs: LIU, ZHAOYANG  (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Ablation;Acceleration;Adhesions;Affect;articular cartilage;Atlases;Automobile Driving;Bioinformatics;career;Cartilage;Catabolic Process;Catalogs;Cells;ChIP-seq;chondroprotection;Clozapine;Coupled;Cyclic AMP;Degenerative polyarthritis;designer receptors exclusively activated by designer drugs;Development;Diagnosis;disability;Disease;Drug Delivery Systems;Drug Formulations;Early Diagnosis;efficacy evaluation;efficacy testing;Engineering;experimental study;Financial Hardship;Forskolin;Functional disorder;functional genomics;G-Protein-Coupled Receptors;Gene Expression Regulation;Genes;Genetic;genetic approach;Genetic Engineering;Genetic Recombination;Genetic Transcription;Genomics;Heterogeneity;Homeostasis;Human;human model;innovation;interest;Joints;lipid nanoparticle;loss of function;Medial meniscus structure;Mediating;Mentors;Modernization;Molecular;mouse genetics;mouse model;Mus;mutant mouse model;Mutant Strains Mice;nanoparticle drug;Natural History;novel;Oxides;Pain management;Pathogenesis;Pathology;Pathway interactions;Persons;Pharmacologic Substance;Pharmacy (field);postnatal;Regulation;Replacement Arthroplasty;Reporting;Research;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Small Interfering RNA;small molecule;Solid;STAT3 gene;Stat3 Signaling Pathway;targeted delivery;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Tissues;Training;training opportunity;Transcriptional Regulation;Transgenic Mice;Traumatic Arthropathy;Work

PROJECT_TITLE: Analyzing the role of cAMP and STAT3 signaling in cartilage homeostasis and osteoarthritis development


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Duchenne/ Becker Muscular Dystrophy;Gene Therapy;Genetics;Muscular Dystrophy;Neurosciences;Pediatric;Rare Diseases;Regenerative Medicine

PHR: Project Narrative We present an innovative strategy for overcoming dystrophin-specific T cell responses by predicting the “strongest” dystrophin epitopes (in register with clinical trial data as it becomes available), then computationally redesigning those epitopes (targeting exons 8-11) to dramatically reduce antigenicity. As a screening platform, novel dystrophin clones will be tested following viral vector transduction of human DMD-iPSC derived engineered muscle tissues and selected based on contractile performance via our high throughput magnetic tissue array platform (Mantarray), followed by in vivo validation within the DMDmdx rat model.

PI_NAMEs: ODOM, GUY LEARY (contact)

PROGRAM_OFFICER_NAME: CONRAD, CHRISTOPHER GARNER

PROJECT_TERMS: 3-Dimensional;Actins;Activities of Daily Living;Address;adenovirus mediated delivery;Affinity;Aftercare;Age Months;Amino Acid Sequence;Amino Acids;Antigen Presentation;Antigen-Presenting Cells;Binding;Biological Assay;Body Weight;Cardiac;cell mediated immune response;Cell Separation;Child;Clinical;Clinical Trials;clinically relevant;Collection;Complex;Computer software;Cytotoxic T-Lymphocytes;Data;data integration;Databases;de-immunization;design;disease phenotype;Disease Progression;Dose;Duchenne muscular dystrophy;Dystrophin;early phase clinical trial;Echocardiography;Engineering;Epitopes;Evaluation;Excision;Exclusion;Exclusion Criteria;Exons;Fiber;Future;gene therapy;gene therapy clinical trial;Gene therapy trial;Gene Transduction Agent;Generations;Genetic Diseases;genomic data;Glycoproteins;Hand Strength;Haplotypes;Head;Helper-Inducer T-Lymphocyte;Hindlimb;Human;Immune;Immune response;Immunity;immunogenic;immunogenicity;Immunologics;in vivo;Individual;induced pluripotent stem cell;innovation;intravenous administration;Magnetism;Major Histocompatibility Complex;mdx mouse;Measures;mechanical properties;micro-dystrophin;mini-dystrophin;miniaturize;Modeling;Muscle;muscle engineering;Muscle Fibers;Muscular Atrophy;muscular system;Mutation;novel;Outcome;Patients;Peptides;Performance;Phase;Phase I Clinical Trials;Phenotype;pre-clinical;predicting response;predictive modeling;predictive tools;prevent;Progressive Disease;Proteins;Proteomics;Protocols documentation;Rattus;Recombinant adeno-associated virus (rAAV);Relaxation;Residual state;Resolution;Respiratory Diaphragm;Role;Running;screening;Selection Criteria;Serious Adverse Event;Signal Transduction;skeletal;Spectrin;Striated Muscles;Structure;symposium;System;T cell response;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Epitopes;Testing;Therapeutic Effect;three dimensional cell culture;Time;Tissue Engineering;Tissue Microarray;treadmill;Update;Validation;Variant;vector;Viral Vector

PROJECT_TITLE: Engineered tissue arrays to streamline deimmunized DMD gene therapy vectors

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders B Study Section[NSD-B]