NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics

ORG_CITY: POUGHKEEPSIE

ORG_NAME: VASSAR COLLEGE

PHR: PROJECT NARRATIVE Translation initiation is the rate-limiting and most highly regulated phase of translation, and its misregulation causes human cancers. Altered expression of each of the subunits composing the multi-subunit eukaryotic initiation factor 3 (eIF3)—a key player in translation initiation and the regulation of translation—causes cancer development and progression, but a mechanism for this link has yet to be elucidated. Our work promises to shed new light on the functional roles of eIF3 and its individual subunits and thus provide a mechanistic framework for their participation in translation initiation, translational regulation, and the development and progression of human cancers.

PI_NAMEs: AITKEN, COLIN  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Academia;Address;Affect;apprenticeship;arm;Automobile Driving;Binding;Biochemical;Biological;Biomedical Research;biophysical techniques;Biophysics;Cancer Etiology;Cancerous;Cell Proliferation;Cells;Collaborations;Communication;Complex;Dedications;Defect;Development;Doctor of Philosophy;Elements;Eukaryota;Eukaryotic Initiation Factor-3;Eukaryotic Initiation Factors;Event;experimental study;factor C;Funding;Genes;Genetic study;genome-wide;graduate student;Human;In Vitro;in vivo;Individual;Industry;Initiator Codon;Investigation;Kinetics;Link;Malignant Neoplasms;Manuscripts;Maps;Messenger RNA;Methodology;Modeling;Monitor;mRNA Translation;Mutation;Participant;Pathway interactions;Peptide Initiation Factors;Phase;Play;Postbaccalaureate;Preparation;prevent;Process;Production;programs;Prokaryotic Initiation Factor-3;Proliferating;Protein Biosynthesis;Protein Isoforms;Proto-Oncogenes;Publishing;Reading Frames;Recombinants;reconstitution;recruit;Resolution;response;ribosome profiling;Ribosomes;RNA Binding;Role;Saccharomyces cerevisiae;Scanning;Science;single molecule;Structure;Students;System;Technology;therapeutic target;Time;Time Study;tool;Training;Transcript;transcriptome;Translation Initiation;Translational Regulation;Translations;undergraduate student;United States National Institutes of Health;Variant;Work;Yeasts

PROJECT_TITLE: THE ROLE OF eIF3 IN mRNA RECRUITMENT


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Precision Medicine;Substance Misuse

ORG_CITY: SAINT LOUIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANESTHESIOLOGY

ORG_FIPS: US

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Chronic postsurgical pain (CPSP) affects 10-20% of patients who undergo surgery and is characterized by marked clinical heterogeneity that underlies the current lack of effective approaches for its prevention or treatment. We aim to understand the biology that drives this heterogeneity, by comprehensively characterizing central and peripheral factors that contribute to CPSP in humans and in rodent models. Our integrated team science approach will identify distinct clinical phenotypes of CPSP and characterize their mechanistic underpinnings, thus narrowing the translational gap toward safe and effective treatment and prevention of CPSP.

PI_NAMEs: CREED, MEAGHAN C;HAROUTOUNIAN, SIMON  (contact);LU, CHENYANG ;RODEBAUGH, THOMAS L;SHEPHERD, ANDREW JOHN;SINHA, PRATIK

PROGRAM_OFFICER_NAME: BACHMAN, JULIA LYNN

PROJECT_TERMS: Abdomen;Acceleration;actigraphy;Address;Affect;Affective;affective disturbance;Animal Model;Animals;Anxiety;Back;Behavior;Bioinformatics;Biological;Biological Factors;Biological Process;Biology;Cells;Characteristics;Chronic;chronic pain;Clinical;Clinical Data;clinical heterogeneity;clinical outcome measures;clinical pain;clinical phenotype;Clinical Psychology;Clinical Trials;clinically relevant;Cognitive;cognitive neuroscience;Complex;Consensus;Cutaneous;Data;Data Collection;Data Set;design;Development;Dimensions;Ecological momentary assessment;effective therapy;Enrollment;experimental study;Failure;FDA approved;flexibility;Frequencies;Functional disorder;Functional impairment;Genomics;Goals;Grant;Guidelines;healthcare burden;Heterogeneity;Human;Immune;Immune response;Immunology;Impairment;improved;individualized prevention;Injury;insight;interdisciplinary collaboration;Intervention;Investigation;Laparotomy;Longitudinal Studies;Machine Learning;Macrophage;Measures;Mechanics;Medicine;Mental Depression;Methods;Modeling;mouse model;multidimensional data;Mus;Muscle;Nerve Fibers;neural;Neurobiology;novel therapeutics;Operative Surgical Procedures;Opiate Addiction;Opioid;opioid overdose;opioid use;opioid use disorder;Outcome;Output;Pain;pain model;Pain Research;patient engagement;patient population;Patient Recruitments;patient stratification;Patients;Perioperative;Peripheral;Peripheral Nerves;Peripheral Nervous System;personalized care;personalized intervention;personalized medicine;Pharmaceutical Preparations;Phenotype;Postoperative Pain;pre-clinical;Pre-Clinical Model;Predisposition;prevent;Prevention;Process;programs;Proteomics;Punishment;Quality of life;Research;Resistance;Reversal Learning;Risk;Rodent;Rodent Model;Science;Sensory;Site;Skin;Skin injury;Sleep;somatosensory;Surgical Injuries;Therapeutic;therapeutic development;trait;transcriptomics;Translating;Translations;Trauma;treatment response;Urogenital Surgical Procedures;Validation;Viscera;Work

PROJECT_TITLE: IMPETUS: Integrated Mechanisms, Phenotypes, and Translational Underpinnings of Chronic Pain after Surgery

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-R (21)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: NORTH CHICAGO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: ROSALIND FRANKLIN UNIV OF MEDICINE & SCI

ORG_STATE: IL

PHR: Project Narrative Defects in genes involved in replication stress response often lead to neurodevelopmental disorders and predisposition to cancer. The Coats Plus disease, caused by dysfunction of genes involved in combating replication stress, is a rare genetic disease characterized by developmental failure of multiple vital organs including brain, eye and GI tract. The proposed research aims to reveal a new signaling pathway regulating the cellular response to replication stress and is expected to yield new mechanistic insights into how cells protect genome stability during perturbed replication and how genome instability leads to disease development.

PI_NAMEs: CHAI, WEIHANG  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Acceleration;Affect;Aging;Bilateral;Binding;Binding Proteins;Biochemical;biological adaptation to stress;Biological Assay;Biophysics;Blood Vessels;bone;Brain;calcification;Calcium;Calcium Signaling;Cells;Chromosome Breakage;Coats plus syndrome;Coats' disease;combat;Complex;Cytoprotection;Data;Defect;design;Development;developmental disease;Disease;DNA;DNA biosynthesis;DNA replication fork;Ensure;Enzymes;Event;Exhibits;Eye;Failure;Functional disorder;gastrointestinal;Gastrointestinal tract structure;Genes;Genetic Diseases;Genome;genome integrity;Genome Stability;Genomic Instability;Goals;Growth;Human;insight;Investigation;Knowledge;Life;loss of function mutation;Maintenance;Malignant Neoplasms;Mediating;Microcephaly;Molecular;multidisciplinary;Mutation;Neurodevelopmental Disorder;novel;nuclease;Organ;pathological aging;Pathological Dilatation;Pathology;Pathway interactions;Phospho-Specific Antibodies;Phosphoproteins;phosphoproteomics;Phosphorylation;Predisposition;preservation;prevent;protein function;Proteins;rare genetic disorder;Reagent;recruit;replication stress;Research;response;Retina;Role;Signal Pathway;Signal Transduction;single molecule;Single-Stranded DNA;Site;SS DNA BP;Stress Response Signaling;System;targeted treatment;Technology;Telangiectasis;Testing;therapeutically effective;Up-Regulation;Work

PROJECT_TITLE: Molecular Basis of Coats Plus Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-X(02)M]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Digestive Diseases;Liver Disease;Neurosciences;Sleep Research

ORG_CITY: NORTHAMPTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: SMITH COLLEGE

ORG_STATE: MA

PHR: Project Narrative Circadian rhythms are fundamental in sculpting physiology, and their alignment is essential for optimal health. We will measure circadian rhythms of the skin and liver in laboratory mice, to determine what the clocks in these tissues are capable of. Our research will help us better target interventions to improve circadian rhythmicity and overall health.

PI_NAMEs: HARRINGTON, MARY E (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Ablation;Animal Model;Animals;Biological Assay;Bioluminescence;Brain;career;circadian;Circadian desynchrony;circadian pacemaker;Circadian Rhythms;Gene Expression;Goals;Health;Histology;Impairment;improved;in vivo;in vivo imaging system;Intervention;Laboratory mice;Length;Lesion;Liver;Measures;Mentors;Methods;Motor Activity;Mus;Periodicity;Peripheral;Physiology;Reporter;Reporting;Research;Role;Science;Skin;Source;Structure;Study models;suprachiasmatic nucleus;System;Testing;Tissues;tool;undergraduate student;Woman

PROJECT_TITLE: In vivo tracking of bioluminescent markers of circadian rhythms in behaving animals


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases;Multiple Sclerosis;Neurodegenerative;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PITTSBURGH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: DUQUESNE UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE In childhood, viral infections in the brain can cause devastating neuropathologies that are characterized by disruptions in developmental myelination and insufficient repair, leading to enduring neurological deficits. We propose a detailed study of the neuroinflammatory impact of viruses on oligodendrocyte precursor cell (OPC) proliferation and differentiation in the developing central nervous system. This work will determine specific cellular interactions between OPCs, immune cells, and virally-infected neurons in the juvenile brain, potentially identifying mechanisms to bolster OPC-mediated regeneration and restore myelination.

PI_NAMEs: O'DONNELL, LAUREN ALENE (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Academic Research Enhancement Awards;Acute;adaptive immune response;Address;Adolescent;Adult;Affect;Age;Animal Model;antagonist;antiviral immunity;Automobile Driving;B-Lymphocyte Subsets;B-Lymphocytes;Binding;Brain;brain cell;brain repair;Bystander Effect;CD46 Antigen;Cell Communication;Cell Count;Cell Differentiation process;Cell Maturation;cell motility;Cell Proliferation;Cells;Central Nervous System;Central Nervous System Diseases;Central Nervous System Infections;Central Nervous System Viral Diseases;Child;Childhood;Complex;critical developmental period;Cues;Data;Demyelinating Diseases;Demyelinations;Development;Doctor of Pharmacy;doctoral student;Educational process of instructing;Encephalitis;experience;experimental study;Genetic;Goals;Immune;Immune response;Immunization;Immunocompromised Host;immunoglobulin receptor;Immunoglobulins;In Vitro;in vivo;Infection;Infiltration;Inflammation;inflammatory milieu;insight;Knowledge;Left;Literature;Measles virus;Mediating;Mentors;Mission;Modeling;Molecular;mouse model;Multiple Sclerosis;Mus;Myelin;myelination;Natural regeneration;Nervous System Disorder;Neurodegenerative Disorders;neuroinflammation;Neurologic Deficit;neuron loss;Neurons;neuropathology;Neurosciences;novel;oligodendrocyte progenitor;Oligodendroglia;Outcome;Output;paracrine;Pathogenicity;Patients;pharmacologic;Play;Positioning Attribute;precursor cell;preservation;Proliferating;Recovery;remyelination;repaired;Research;Research Personnel;response;restoration;Role;Series;Signal Transduction;Stress;student mentoring;Students;Survivors;Testing;Therapeutic;therapy development;tool;Training;undergraduate student;Viral;virology;Virus;Virus Diseases;virus-induced demyelination;Vulnerable Populations;Work

PROJECT_TITLE: Rescuing myelination in viral infections of the juvenile brain

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: ANN ARBOR

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE This proposal will interrogate a novel cell population identified in the developing human lung, referred to as Fetal Airway Secretory (FAS) cells, that are marked by SCGB3A2/SFTPB/CFTR. Since nothing is known about FAS cells, and there is no analogous population in the murine lung, the overarching goal of this proposal is to use an in vitro model of FAS differentiation to describe these cells in detail, to interrogate their differentiation potential, and to determine how they are regulated, thereby providing foundational descriptive and mechanistic insights into a new cell type in the human lung.

PI_NAMEs: SPENCE, JASON  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: ASCL1 gene;Atlases;Bar Codes;Basal Cell;Biology;Cell Differentiation process;Cell Lineage;Cell surface;cell type;Cells;Conceptions;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Epithelial Cells;Epithelium;experimental study;fetal;follow-up;Gene Expression Profile;Gene Modified;Genes;genetic signature;Goals;Human;In Vitro;in vitro Model;inhibitor;insight;Lung;MADH2 gene;Mediating;Methods;Modeling;Mus;Neuroendocrine Cell;novel;Organoids;pharmacologic;Phase;Population;progenitor;Publishing;Reporting;Secretory Cell;Signal Transduction;single-cell RNA sequencing;stem cells;System;Testing;Time Series Analysis;Tissues;tool

PROJECT_TITLE: Functional interrogation of a novel SCGB3A2+/SFTPB+ cell in the human airway

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-A(03)]


ADMINISTERING_IC: EB

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Nanotechnology;Neurodegenerative;Neurosciences;Parkinson's Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: DURHAM

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF NEW HAMPSHIRE

ORG_STATE: NH

PHR: Narrative Alzheimer's and Parkinson's diseases are fundamentally characterized by damage and death of brain cells. The development of reproducible and well-defined experimental procedures for cell (replacement) therapies is critical. The bioinks we will engineer may have the potential to be utilized in the creation of a wide range of cell therapy products and in the identification of new therapeutics.

PI_NAMEs: SUH, WON HYUK  (contact)

PROGRAM_OFFICER_NAME: RUSSELL, LUISA MARIE

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;adult stem cell;Alzheimer's Disease;Analysis of Variance;Biochemical;bioink;biomaterial compatibility;Biopolymers;bioprinting;Brain;brain cell;Cell Death;Cell Therapy;Cells;Cessation of life;Chemicals;Collagen;cost;crosslink;Crosslinker;curve fitting;Custom;cytotoxicity;data acquisition;Development;Differentiation Antigens;Disease;Encapsulated;Engineering;Ensure;Environment;Enzymes;experimental study;Flow Cytometry;Fluorescence Microscopy;Formulation;Fostering;Gelatin;Gene Expression Profile;Glutaminase;Goals;healthcare burden;high throughput screening;Human;human stem cells;human tissue;Hydrogels;Image;Induced Neurons;induced pluripotent stem cell;Ions;Liquid substance;Manuals;matrigel;Methodology;Methods;microbial;Molecular;nanoparticle;nerve stem cell;Neurodegenerative Disorders;Neuronal Differentiation;Neurons;neurotoxic;novel;novel therapeutics;Organoids;Outcome;Parkinson Disease;Patient-Focused Outcomes;peptide amphiphiles;Pharmaceutical Preparations;pharmacologic;Pluripotent Stem Cells;Polysaccharides;Procedures;Process;Production;Proteins;Public Health;Reproducibility;Research;response;Rotenone;screening;Silicon Dioxide;Source;spheroids;Statistical Data Interpretation;Staurosporine;stem cell differentiation;stem cells;Testing;three dimensional cell culture;Tissue Engineering;Tretinoin;Water;Work;Writing

PROJECT_TITLE: Utilizing Bioprinted Human Stem Cells for Molecular Screening via Multi-Material Strategies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-T (82)]


ORG_CITY: KANSAS CITY

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI KANSAS CITY

PHR: Project Narrative: In the short term, the project will contribute to the understanding of how yeast cells communicate and organize in communities through shared metabolites. In the longer term, this knowledge may provide a framework for how environmental factors and cell- cell signals affect human development, tumor progression, and deadly pathogenic biofilms.

PI_NAMEs: HONIGBERG, SAUL M (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Acetates;Affect;Biological;Biological Assay;Buffers;Catheters;Cell Communication;Cell Physiology;cell type;Cells;Communication;Communities;community organizations;Complex;Cues;Development;Diffusion;Diploidy;Disease;DNA Sequence Alteration;Environment;Environmental Risk Factor;Equilibrium;experience;experimental study;flexibility;Flow Cytometry;Food;Foundations;Gene Expression;Generations;Genetic;Genetic Models;Health;Heart Valves;Human Development;human disease;human tissue;Immunocompromised Host;Individual;intercellular communication;Knowledge;Lactic acid;Mass Spectrum Analysis;Measures;Medical Device;Meiosis;Methods;microbial;Microbial Biofilms;microbial community;microorganism;Molecular;Mutation;Names;Organism;Pathogenicity;Pathway interactions;Pattern;Pattern Formation;Permeability;Planet Earth;Play;Production;promoter;Proteins;Reproduction spores;Research;Resistance;response;Role;Saccharomyces cerevisiae;secondary metabolite;Signal Pathway;Signal Transduction;small molecule;Stress;System;Temperature;Testing;Thick;tool;Transcription Coactivator;transcription factor;tumor progression;Yeasts

PROJECT_TITLE: Cell-cell signaling and pattern formation in yeast

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-J (81)]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: Project Narrative Acute respiratory distress syndrome is an unrelenting inflammation of the lungs that occurs after various insults such as influenza infection. This proposal will evaluate mechanisms that drive the persistent inflammation after injury, and the knowledge gained can be applied to the development of new therapeutic options for patients with lung inflammation.

PI_NAMEs: CHEN, PETER  (contact);PARKS, WILLIAM C

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Acute Respiratory Distress Syndrome;airway epithelium;alveolar epithelium;Apoptosis;Apoptotic;Attenuated;Biological Assay;Biology;Cell Death;Cell surface;Cells;Cessation of life;Data;Development;Disease;Eating;Epithelial Cells;Epithelium;Etiology;Failure;Feedback;Goals;Immune response;Immunity;immunoregulation;Immunosuppression;Impairment;improved;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;Influenza;influenza infection;Injury;insight;Intervention;Knowledge;Learning;Link;Lung;lung injury;lung repair;Macrophage;Mediating;Modeling;Morbidity - disease rate;Mus;Necrosis;neutrophil;novel;novel therapeutics;Outcome Study;Pathologic;Pathway interactions;Patients;Phagocytes;Phagocytosis;Phenotype;prevent;Process;programs;Proteoglycan;Pulmonary Inflammation;recruit;repaired;Reporting;Research;Resolution;response;Risk Factors;Role;Signal Transduction;syndecan;Testing;Tissues;Virus Diseases;Wild Type Mouse;wound healing

PROJECT_TITLE: Syndecan-1 suppression of lung inflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-A(05)]


ADMINISTERING_IC: AT

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: American Indian or Alaska Native;Back Pain;Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Clinical Research;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pain Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: 08. Project Narrative   Native Americans experience higher rates of chronic pain than the general US population, yet the mechanisms for this pain disparity are poorly understood. This study proposes that exposure to nature degradation (a societal-level stressor) increases psychological stress, heightens somatic threat sensitivity, and increases allostatic load to produce a unique Native American pain risk phenotype (“silent” spinal sensitization; i.e., sensitization of spinal pain neurons that does not result in sensitization of pain experience). Results from this study will help inform public policies, as well as identify mechanistic targets for interventions, to reduce Native American chronic pain risk.

PI_NAMEs: RHUDY, JAMIE LYNN (contact)

PROGRAM_OFFICER_NAME: MUDD, LANAY MARIE

PROJECT_TERMS: Address;allostatic load;Arthritis;Back Pain;Brain;Buffers;cardiometabolism;Cardiovascular Diseases;Cardiovascular system;Censuses;Central Nervous System;central sensitization;Chronic Disease;chronic pain;Colonialism;community engaged research;community partners;Data;design;Diabetes Mellitus;disability;Discrimination;Disparity;Electrophysiology (science);Environment;Environmental Impact;Environmental Pollution;Event;Excision;experience;Exposure to;Generations;Genocides;hazard;health disparity;Hypertension;Indigenous;Individual;Industrial Waste;innovation;insight;Institutional Review Boards;Intervention;Justice;Link;Mediating;Mental Health;Methods;Modeling;Native American community;Native Americans;Nature;Neurons;Neurosecretory Systems;Nociception;Not Hispanic or Latino;Pain;pain chronification;Pain Free;pain inhibition;Pain Measurement;pain processing;pain signal;Participant;Pathway interactions;Patient Self-Report;perceived discrimination;perceived stress;Phenotype;physical conditioning;Physiological;Policies;Pollution;Population;precision medicine;prevent;prospective;Psychological Stress;Psychosocial Stress;Public Policy;Race;racism;Reflex action;Research;Research Proposals;resilience;resilience factor;Resources;response;Risk;Role;Spinal;Spine pain;Stress;Structural Racism;System;Tribes;Underserved Population;Work

PROJECT_TITLE: The Oklahoma Study of Native American Pain Risk: Stress and Resilience Mechanisms


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Primary Health Care;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: Aurora

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Parents of preterm infants requiring hospitalization in a neonatal intensive care unit (NICU) are at high risk for mental health conditions. Adverse parental mental health has potentially devastating consequences for parents and infants. Developing an acceptable, feasible, and effective telehealth-based mental health screening and engagement program for NICU parents would increase identification of parents at risk for mental health conditions, improve access to mental health services, and ultimately improve parent mental health and infant health and developmental outcomes.

PI_NAMEs: KLAWETTER, SUSANNE  (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: acceptability and feasibility;Accident and Emergency department;Acute;Address;Administrator;Adoption;Affect;Anxiety;Award;Awareness;Behavior Therapy;behavioral outcome;Biometry;Birth;Breast Feeding;care systems;career;Caring;Case Series;Child;Child Care;Child Development;Child Health;Child Rearing;Clinical;clinical practice;clinically significant;Cognitive;Collaborations;Community Mental Health Services;COVID-19 pandemic;Data;Data Collection;depressive symptoms;Development;Doctor of Philosophy;Effectiveness;effectiveness/implementation trial;Eligibility Determination;Ensure;experience;Family;Funding;Goals;health care service;health economics;health information technology;Health Personnel;Health Services Research;Healthcare Systems;high risk;Home;hospital readmission;Hospitalization;Hospitals;implementation science;Improve Access;improved;Infant;Infant Health;innovation;Institution;Learning;Logistics;Maintenance;Maternal Mortality;meetings;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Mentored Clinical Scientist Development Program;Mentorship;Methods;multidisciplinary;Neonatal Intensive Care Units;Nurses;Outcome;parenting intervention;Parents;Perinatal;perinatal health;pilot test;Post-Traumatic Stress Disorders;pragmatic implementation;Premature Infant;Prevalence;Preventive healthcare;Primary Care;primary care provider;Procedures;professor;Program Acceptability;programs;Public Health Informatics;Qualitative Research;Randomized;randomized trial;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Activity;Research Personnel;Review Committee;Risk;Rural Health;rurality;screening;Self Efficacy;Services;Site;skills;social stigma;Social Workers;socioeconomics;Statistical Methods;Structure;success;Suicide;Symptoms;telehealth;tenure track;Testing;Time;Training;Training Activity;Transportation;United States Preventative Services Task Force;Universities;urgent care;Work

PROJECT_TITLE: The Development of PATH, a Program to Support NICU Parent Mental Health Through the Transition from Hospital to Home

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunotherapy;Infectious Diseases;Prevention

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative There are four ACTG protocols in late state of development and one recently opened that will be conducted entirely at African sites (A5416 and A5417) or will include South American sites (A5374, A5388 and A5389). These will evaluate broadly neutralizing antibodies alone or in combination with other immune therapeutic interventions in different study populations, including PWH at primary infection, started on ART during primary infection and chronically suppressed on ART. These are highly complex studies that involve multiple investigational products and include a period of analytical treatment interruption with close monitoring of participants. The success of these studies depends on the engagement and training of multiple stakeholders that include regulators and ethics committee boards, site investigators and staff, community members and advocates, potential participants and their partners and providers. It is therefore imperative for our network to support our existing sites during the expansion of our Cure research agenda. Such efforts include (1) training staff on the need for Cure interventions and scientific rationale underlying current investigational strategies and on (2) the rationale for the use of ATIs in the evaluation of such interventions, as well as the risks and mitigation plans around ATIs; (3) engagement with regulators, community members, providers and participant families and partners; (4) providing appropriate infrastructure for the conduct of the studies and associated procedures, including appropriate sample collection, processing and storage.

PI_NAMEs: CURRIER, JUDITH S. (contact);ERON, JOSEPH J

PROGRAM_OFFICER_NAME: OJUMU, AKINLOLU O

PROJECT_TERMS: Advocate;African;Aging;aging process;aging related;AIDS clinical trial group;Cardiovascular Diseases;Cell Aging;Chronic;Clinical;Communities;comorbidity;Complex;Cross-Sectional Studies;Data;Development;Diabetes Mellitus;Ethics Committees;Evaluation;experience;Family;frailty;Funding;Future;General Population;Geroscience;Growth;HIV;HIV Infections;HIV/AIDS;immune function;Immunotherapy;Infection;Inflammation;Infrastructure;interest;Interruption;Intervention;Intervention Trial;Measurable;member;Monitor;neutralizing antibody;Observational Study;Older Population;Participant;Persons;phenotypic biomarker;potential biomarker;prevent;Primary Infection;Procedures;Process;Protocols documentation;Provider;Research;Research Personnel;Risk;sample collection;senescence associated secretory phenotype;senescent cell;Senotherapeutic;Site;South American;study population;success;Therapeutic;therapeutic target;Tissues;Training;Work

PROJECT_TITLE: Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_DEPT: CHEMISTRY

ORG_NAME: OCCIDENTAL COLLEGE

PHR: Project Narrative  Small organic molecules are central to the development of pharmaceutical treatments, biological probes, and many other chemical tools that impact human health. This proposal aims to develop the generation and use of ketone-derived carbon-centered radicals for the synthesis of carbon-carbon bonds that make up the structural backbone of many bioactive small molecules. Furthermore, this research would feed the pipeline of biomedical research scientists by providing strong training opportunities for undergraduates.

PI_NAMEs: CANNON, JEFFREY  (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TITLE: Photocatalyzed and Enantioselective Umpolung C-C Bond Forming Reactions of Carbonyls

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


ORG_CITY: ATLANTA

ORG_DEPT: PATHOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Our proposal studies why HIV reservoirs decay at different rates in HIV-infected individuals on antiviral therapy. We hypothesize that reservoir contraction and expansion occur simultaneously in all HIV-infected individuals making the reservoir appear stable. We propose to perturb these forces to identify the drivers behind them and to ultimately reduce the size of the HIV reservoir.

PI_NAMEs: O'DOHERTY, UNA T (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Acceleration;Acute;Affect;Anti-sense RNA;Anti-viral Therapy;Antigens;antiretroviral therapy;Bar Codes;Categories;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Cycle Arrest;Cell Death;Cell division;Cells;Cessation of life;Chronic;Clonal Expansion;cohort;cytotoxicity;Data;deep sequencing;design;driving force;Exons;experimental study;Gene Silencing;Genes;genetic makeup;Genetic Transcription;Goals;HIV;HIV Infections;Immune;immune clearance;Immune response;Immune system;Immune Targeting;In Vitro;in vitro Model;in vivo;Individual;Infection;Integration Host Factors;integration site;Introns;latent HIV reservoir;Location;longitudinal analysis;Measures;Methods;Monitor;mutant;Mutate;Oncogenes;Open Reading Frames;pressure;Proliferating;promoter;protein expression;Proteins;Provirus Integration;Proviruses;Resistance;Rest;RNA Splicing;Role;Sample Size;Site;Testing;Time;Toxic effect;Transcript;transcriptome sequencing;Untranslated RNA;Viral;Viremia;Virus;Work

PROJECT_TITLE: Determinants of reservoir contraction and expansion in vivo, ex vivo, and in vitro

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Immunotherapy;Networking and Information Technology R&D (NITRD)

ORG_CITY: SAN FRANCISCO

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PI_NAMEs: BRUNO, PETER MICHAEL (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Address;algorithm development;Algorithms;Antigen Presentation;Antigen Targeting;antigen-specific T cells;Antigens;Binding;Biochemical;cancer recurrence;cancer therapy;cancer type;cohort;combinatorial;Complex;Computer Models;Computing Methodologies;cytotoxicity;Data;Data Set;design;Development;Educational process of instructing;Engineering;Epitopes;Event;extend lifespan;Face;Feedback;Generations;Genetic Screening;Germ Lines;Goals;Grant;Herpesviridae;high throughput screening;Human;immune checkpoint blockade;Immune response;Immune system;Immunity;Immunology;Immunoprecipitation;Immunotherapy;improved;insight;Institution;large scale data;Libraries;Ligands;Machine Learning;Malignant neoplasm of lung;Malignant Neoplasms;Mass Spectrum Analysis;Melanoma;method development;Modeling;Molecular;mouse model;Mutation;next generation;novel drug class;Peptide Library;Peptide/MHC Complex;Peptides;personalized medicine;Pharmaceutical Preparations;quantum;reconstitution;Research Personnel;response;Source;Specificity;structural biology;Structure;synthetic biology;System;T cell response;T cell therapy;T memory cell;T-Cell Antigen Receptor Specificity;T-Cell Receptor;T-cell receptor repertoire;T-Cell Receptor Therapy;T-Lymphocyte;Testing;Therapeutic;therapy design;Toxic effect;Training;training data;tumor;Tumor Antigens;Uncertainty;Variant;Vision;Work

PROJECT_TITLE: MATCHMAKERS - Solving T-cell receptor recognition and design via integrated high-throughput screening and structural, functional and computational approaches


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Not applicable per solicitation. Project Narrative: Do not complete. Note: ASSIST screens will show an asterisk for this attachment indicating it is required. However, eRAsystems only enforce this requirement in the Overall component and applications will not receive an error if omitted in other components.

PI_NAMEs: PIKOV, VICTOR  (contact)

PROGRAM_OFFICER_NAME: HUDAK, ERIC MICHAEL

PROJECT_TITLE: HORNET  Center for Autonomic Nerve Recording and Stimulation Systems (CARSS)


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Digestive Diseases;Inflammatory Bowel Disease;Neurosciences;Urologic Diseases

PI_NAMEs: HITTI, RAJA EDWARD (contact)

PROJECT_TERMS: Abdomen;Accelerometer;Action Potentials;Address;Algorithms;Ally;Architecture;Autoimmune Diseases;autonomic nerve;bioelectronics;Bladder;Bluetooth;Cervical;Chronic;Clinical;Clinical Research;Colon;Colon Carcinoma;Colorectal;Communication;Constipation;Crohn's disease;Darkness;Dedications;Development;Diameter;Disease;Dyspepsia;electric impedance;Electrocardiogram;Electrodes;Electromyography;Epilepsy;Face;FDA approved;Fecal Incontinence;flexibility;Gastrointestinal Motility;Gastroparesis;Heart;Ileus;Implant;Individual;Inflammatory Bowel Diseases;interest;Lead;Light Exercise;Lower urinary tract;Lung;mathematical ability;Medicine;Modality;Monitor;Morphologic artifacts;Motility;motility disorder;Motion;Movement;Muscle;Nausea;Nerve;nerve supply;neuroregulation;Obesity;obesity treatment;open source;operation;Organ;Overactive Bladder;Pelvis;Physiologic pulse;polydimethylsiloxane;Postoperative Period;Research Personnel;Rheumatoid Arthritis;Sacral nerve;signal processing;Signal Transduction;Stomach;Stroke;Substance Use Disorder;System;Technology;Temperature;Testing;treatment-resistant depression;Ulcerative Colitis;vagus nerve stimulation;wearable device;Withdrawal


PI_NAMEs: MENG, ELLIS  (contact)

PROJECT_TERMS: 3-Dimensional;Address;Adopted;Ally;Architecture;autonomic nerve;Autonomic nervous system disorders;Biocontrols;bioelectronics;Clinical;cost;Custom;design;Diameter;Elasticity;Electrodes;Equilibrium;fabrication;Film;flexibility;Foreign Bodies;Health;Hypertension;Immune response;Implant;Individual;Inflammatory Bowel Diseases;instrument;interest;Lead;manufacture;manufacturing technology;Measures;Medical;Medicine;Memory;Metals;Methods;Microfabrication;miniaturize;minimally invasive;Molds;Nerve;Nerve Fibers;neural;Non-Insulin-Dependent Diabetes Mellitus;novel;open source;Operative Surgical Procedures;parylene;parylene C;Perineuriums;Peripheral;Peripheral Nerves;Peripheral Nervous System;polydimethylsiloxane;Polymers;preservation;Process;Recording of previous events;Research;Rheumatoid Arthritis;Scheme;Shapes;Site;Structure;Surgical sutures;System;Testing;Thick;Thinness;tool;Welding;wound


ADMINISTERING_IC: CE

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

PHR: Project Narrative The MI-YVPC will work in partnership with two communities to study implementation and effectiveness of two distinct strategies for firearm violence prevention. The Center will include a partnership and staffing plan that includes a multi-disciplinary research team with experience partnering with community residents, organizations, and institutions, to implement and evaluate community level violence prevention strategies.

PI_NAMEs: ZIMMERMAN, MARC A (contact)

PROJECT_TITLE: CE21-005 - Michigan Youth Violence Prevention Center: Building Evidence for Gun Violence Prevention


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Diabetes;Nutrition;Prevention;Social Determinants of Health

ORG_CITY: PORTLAND

ORG_NAME: MAINEHEALTH

ORG_STATE: ME

PI_NAMEs: SCHARNETZKI, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Adult;Alcohol consumption;Behavior;Behavioral;Biochemical Pathway;Body Weight;Buffers;Caring;Centers of Research Excellence;Clinical;Clinical Treatment;diabetes management;Diabetes Mellitus;Diagnosis;Disease;evidence base;experience;Fright;Goals;Health behavior change;Health Professional;Health Promotion;High Prevalence;HIV risk;improved;Individual;Intervention;Mesenchymal;Metabolic;mortality;multi-component intervention;neuroregulation;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Pathway interactions;Patient-Focused Outcomes;Patients;Personal Satisfaction;Persons;Phase;Physiological;Process;programs;psychologic;psychosocial;Public Health;Quality of life;Reporting;Research;Risk Factors;Risk Reduction;Sampling;social stigma;Source;stressor;theories;Tobacco;tool;treatment risk;United States;uptake;Weight;Weight maintenance regimen

PROJECT_TITLE: Strategies to Improve Well-Being and Diabetes Management


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: Newark

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE Hypoxic ischemic encephalopathy (HIE) is the leading cause of cerebral palsy in children born at term and can cause many additional neurodevelopmental disabilities. This proposal will investigate the mechanisms of neuroinflammation and develop novel technologies to reduce injury from inflammation after HIE.

PI_NAMEs: DUNCAN, MELINDA K (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Abruptio Placentae;Adult;Affect;Alginates;Amniotic Fluid;Animal Model;Anti-Inflammatory Agents;Attention deficit hyperactivity disorder;autism spectrum disorder;Birth;Blood;Brain;Brain Injuries;Cause of Death;Cell Wall;Cells;Cerebral Palsy;Cerebrum;Child;Clinical;Cognitive deficits;Communication;Complex;Cord prolapse;Country;cytokine;Data;Delaware;delivery complications;design;Developed Countries;Developmental Delay Disorders;Dose;Drug Delivery Systems;effective therapy;Epilepsy;Exposure to;fetal;fetal brain injury;Fetal Spleen;Fetal Tissues;Fetus;Fever;Flow Cytometry;Functional disorder;functional outcomes;Funding;Hand Strength;Histologic;Histology;Hour;Human;Hydrogels;Hypotension;Hypoxia;Image;Immune;immune activation;immune function;immune modulating agents;Immune response;Immunologic Factors;immunoregulation;Impairment;improved;in vivo imaging system;Incidence;Infant;Infection;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Injectable;Injections;Injury;Intellectual functioning disability;Interleukin-6;Interleukins;intraamniotic infection;Intraperitoneal Injections;Investigation;Ischemia;Label;Late Effects;Learning Disorders;Lifelong disability;Live Birth;Location;Long term disability;Maternal-Fetal Exchange;Measures;Microglia;Modeling;Mothers;Motor;motor deficit;mouse model;Mus;natural hypothermia;Neonatal;Neonatal Brain Injury;neonatal encephalopathy;neonatal hypoxic-ischemic brain injury;neonatal mice;Nervous System Disorder;neural;Neurodevelopmental Disability;Neurodevelopmental Impairment;Neuroimmune;neuroinflammation;Neurological outcome;neuroprotection;new technology;novel;novel strategies;offspring;Oxygen;pathogen;Peripheral;Placenta;Placental Insufficiency;Pregnancy;pup;Regulatory T-Lymphocyte;Research Personnel;Risk;Risk Factors;Rodent Model;Route;Schizophrenia;Science;Serum;spatiotemporal;Survivors;System;systemic inflammatory response;T-Cell Activation;Testing;Therapeutic;Therapeutic Agents;Time;tool;Uterine Rupture;Uterus;Virus Diseases

PROJECT_TITLE: Delaware INBRE


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Infant Mortality;Lung;Pediatric;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: PEDIATRICS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: NARRATIVE Stimulating heart muscle cell division is the holy grail of heart regeneration research. We will perform a clinical trial of β-blocker administration with the goal of increasing heart muscle cell division in infants with Tetralogy of Fallot, the most common form of cyanotic congenital heart disease. We will use a newly developed method to unequivocally quantify heart muscle cell division as primary outcome.

PI_NAMEs: KUHN, BERNHARD  (contact)

PROGRAM_OFFICER_NAME: BURNS, KRISTIN

PROJECT_TERMS: Academy;Adrenergic beta-Antagonists;Age Months;American;Arrhythmia;beta-adrenergic receptor;Birth;cardiac magnetic resonance imaging;Cardiac Myocytes;cardiac regeneration;Cardiac Surgery procedures;Cardiovascular Surgical Procedures;Cell division;Cell Proliferation;Characteristics;Child;Clinical;clinical center;Clinical Trials;cohort;Congenital Abnormality;congenital heart abnormality;Cyanotic heart disease;Data;Development;Diagnosis;Diagnostic;DNA;Double-Blind Method;Drug Kinetics;Echocardiography;editorial;experience;follow-up;Foundations;Future;Generations;Goals;Growth;Guidelines;Health;Heart;Heart failure;Heart Hypertrophy;Human;Hypertension;Hypertrophy;Hypoplastic Left Heart Syndrome;improved;in vivo;infancy;Infant;Infant Mortality;innovation;Interruption;Investigation;Isotopes;Journals;Label;Long-Term Care;mass spectrometric imaging;Medicine;Methods;Molecular;Myocardial;Myocardium;neonatal mice;New England;novel;Operative Surgical Procedures;Outcome;Pathologic;Pathology;Patients;Pediatric Hospitals;Pediatrics;Persons;pharmacologic;Physiologic intraventricular pressure;Placebo Control;Placebos;postnatal;preclinical study;prevent;primary outcome;Proliferating;Propranolol;Protocols documentation;Publishing;Pulmonary Valve Stenosis;Randomized;randomized trial;Randomized, Controlled Trials;Receptor Signaling;recruit;Regenerative research;repaired;Research;Research Infrastructure;response;right ventricular failure;Right Ventricular Hypertrophy;right ventricular remodeling;Risk;Safety;Sampling;secondary outcome;Signal Transduction;skills;spelling;stable isotope;Strawberry nevus;success;Supraventricular tachycardia;Testing;Tetralogy of Fallot;Thoracic Surgical Procedures;Thymidine;Time;Ventricular;ventricular hypertrophy;Visit;Visualization;Work

PROJECT_TITLE: Mechanistic clinical trial of Beta-blocker administration for reactivating cardiomyocyte division in Tetralogy of Fallot

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Dissemination and Implementation Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention

ORG_CITY: BOSTON

ORG_NAME: UNIVERSITY OF MASSACHUSETTS BOSTON

PHR: Project Narrative Despite strong consensus that early, specialized intervention for children with Autism Spectrum Disorder (ASD) can have a dramatic impact on outcomes, the public health system’s capacity to provide such services is severely challenged by the rapid rise in ASD prevalence. The goal of this research is to increase timely and equitable access to ASD-specialized early intervention during the critical first three years of life by capitalizing on the existing infrastructure of the Part C Early Intervention (EI) system, which is publicly funded and available in all U.S. States. This project will train EI providers to use an evidence-based, inexpensive, parent-mediated intervention that can improve child and family outcomes as well as mitigate the substantial economic costs associated with ASD.

PI_NAMEs: CARTER, ALICE S. (contact)

PROGRAM_OFFICER_NAME: PUGLIESE, CARA ELISABETH

PROJECT_TERMS: acceptability and feasibility;Address;Aftercare;Age;Area;autism spectrum disorder;autism symptoms;autistic children;Behavior;Behavior Therapy;Birth;Characteristics;Child;Child Language;Child Rearing;clinically relevant;Code;Consensus;Consensus Development;Consultations;Data;data management;Development;Developmental Delay Disorders;Developmental Disabilities;dosage;Early Intervention;economic cost;Educational process of instructing;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness/implementation design;effectiveness/implementation hybrid;Equity;evidence base;Evidence based intervention;Family;Family member;follow-up;Funding;Future;Goals;Health system;Heterogeneity;Home;hybrid type 1 design;Hybrids;implementation determinants;implementation evaluation;improved;improved outcome;Individuals with Disabilities Education Act;Infrastructure;innovation;Intervention;intervention program;Interview;joint attention;Language;Language Development;language outcome;Lead;Learning;Life;Measures;Mediating;member;Methods;Modification;Motor;multi-site trial;National Institute of Mental Health;Outcome;Parents;Patient Self-Report;Personal Satisfaction;Play;Population;Prevalence;Procedures;Protocols documentation;Provider;provider intervention;Public Health;quality assurance;Quality of life;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Reporting;Research;Role;Sample Size;Sampling;Self Efficacy;service delivery;service intervention;Services;Site;social communication;Source;Stress;System;Technology Assessment;Testing;Training;treatment as usual;treatment effect;Variant

PROJECT_TITLE: 4/4: Improving the Part C Early Intervention Service Delivery System for Children with ASD: A Randomized Clinical Trial


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Hematology;Human Genome;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative We propose to determine how MYC initiates and maintains tumorigenesis. We have generated a library of conditional transgenic mouse models for MYC-driven cancer and human PDX models that we will use to identify novel vulnerabilities in MYC-driven cancers through RNAseq, ChIPseq and DESI-MSI, CRISPR synthetic lethal screens and MYC function reporter systems. Our collaborative research proposal will identify novel therapeutic targets for MYC driven cancer.

PI_NAMEs: FELSHER, DEAN W (contact)

PROGRAM_OFFICER_NAME: GHOSH-JANJIGIAN, SHARMISTHA

PROJECT_TERMS: Acute;Adenocarcinoma Cell;anti-cancer research;bcr-abl Fusion Proteins;Biological Models;cancer therapy;carcinogenesis;Cells;ChIP-seq;Clustered Regularly Interspaced Short Palindromic Repeats;Exhibits;Genes;Glean;Goals;Human;Immune;In Vitro;in vivo;innovation;insight;leukemia;Libraries;lipid biosynthesis;Lung Adenocarcinoma;Lymphoma;Malignant Neoplasms;metabolomics;Methods;Modeling;Molecular;mouse model;MYC gene;new technology;new therapeutic target;novel;novel therapeutics;nucleocytoplasmic transport;Oncogenes;Osteosarcoma;Pathway interactions;patient derived xenograft model;Primary carcinoma of the liver cells;Productivity;programs;Renal Cell Carcinoma;Reporter;Research;Research Personnel;Research Proposals;RNA;Role;Seminal;System;T-Lymphocyte;Tetracyclines;transcriptome sequencing;Transgenic Mice;tumor;tumorigenesis;Work

PROJECT_TITLE: Targeting the MYC Pathway for the Treatment of Cancer


FUNDING_MECHANISM: SBIR/STTR CONTRACTS

ORG_CITY: PHILADELPHIA

ORG_NAME: CHIMERON BIO CORPORATION

PI_NAMEs: SIMMONS, ALFRED  (contact)

PROJECT_TERMS: APC gene;APC mutation;Award;Benchmarking;Benign;Biological Assay;Cancer Vaccines;CD8-Positive T-Lymphocytes;Cells;Colon;Colorectal Cancer;comparison control;design;Detection;Development;Disease;Exhibits;Familial Adenomatous Polyposis Syndrome;Genes;Hereditary Disease;Immune response;immunogenicity;Immunologic Stimulation;In Vitro;interest;KRAS2 gene;Malignant Neoplasms;Measurable;Measures;Mus;mutant;Mutate;nanoparticle;nanoparticle delivery;neoantigens;neutralizing antibody;particle;Patients;Peptides;Phase;Polyps;prevent;Production;Proteins;Rectum;response;RNA amplification;Safety;Sarna;self assembly;Serum;Therapeutic;tumor;Tumor Suppressor Genes;uncontrolled cell growth;Vaccines;vector;WNT Signaling Pathway;Work

PROJECT_TITLE: PHASE I THERAPEUTIC AWARD: CHIMERIC NANOPARTICLE DELIVERY OF AN SARNA-BASED CANCER VACCINE FOR FAMILIAL ADENOMATOUS POLYPOSIS


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Biotechnology;Chronic Pain;Gene Therapy;Genetics;Neurosciences;Pain Research;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative: The proposed research describes studies to support the development, optimization, and proof-of- concept efficacy of a novel gene therapy-based treatment for severe pain in the elderly.

PI_NAMEs: WAINGER, BRIAN JASON (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: adenovirus mediated delivery;Adult;Adverse effects;Affect;aggressive therapy;Aging;Animal Model;animal old age;Arthritis;Award;Behavioral;Bioinformatics;Biology;Candidate Disease Gene;Cell model;cell type;Cells;chronic pain;Clinical Trials;comorbidity;Congenital Pain Insensitivity;Contralateral;cost;Data;dermatome;design;Development;Dose;Drug usage;effective therapy;Elderly;Electrophysiology (science);experience;gain of function mutation;gene therapy;Gene Transduction Agent;Genes;Genetic Models;Genetic Transcription;Goals;Human;Human Genetics;human induced pluripotent stem cells;Impairment;in vivo;Individual;induced pluripotent stem cell;Inflammatory;Inherited;Injections;Intra-Articular Injections;Intractable Pain;Intramuscular;Ipsilateral;knock-down;Knock-out;Label;Measures;Medical;Molecular;Motor Neurons;mouse model;Mus;nerve stem cell;neuronal cell body;Neuropathy;Nociceptors;novel;novel strategies;old mice;older patient;Older Population;opioid epidemic;overexpression;Pain;Pain management;pain model;pain signal;patch clamp;patch sequencing;Pathologic;Phase;Phenotype;Physiological;Polypharmacy;Postoperative Pain;Potassium Channel;preclinical development;Prevalence;prevent;promoter;Promoter Regions;Quantitative Reverse Transcriptase PCR;Research;Risk;Route;Safety;Serotyping;side effect;Signal Transduction;socioeconomics;Sodium Channel;Specificity;Spinal Cord;Spinal Ganglia;stem cell model;targeted treatment;Testing;Toxic effect;Transcript;Translations;treatment optimization;treatment strategy;Validation;voltage;Voltage-Gated Potassium Channel

PROJECT_TITLE: Toward Precision Gene Therapy for Treatment of Severe Pain in Older Individuals

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Nutrition;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Pediatric Chronic Kidney Disease-Mineral Bone Disorder is a comorbidity of CKD that impacts the skeletal and cardiovascular health of pediatric patients. Unfortunately, despite the importance of this entity, our current treatment guidelines do not enable individualized therapy despite evidence that a one-size fits all approach is inadequate. This proposal seeks to identify genetic variants that predict skeletal behavior in pediatric CKD- MBD and thereby allow the individualization of therapy.

PI_NAMEs: LASTER, MARCIANA LEE (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Adult;Affect;African American;African American population;Behavior;Biochemical;Biometry;bone;Bone Diseases;bone turnover;California;Cardiac;cardiovascular health;Cardiovascular system;Caucasians;Child;Childhood;Chronic;Chronic Kidney Failure;Clinical;cohort;comorbidity;Complex;Coupled;Data;Deformity;diagnosis standard;Dialysis patients;Dialysis procedure;Educational workshop;End stage renal failure;epidemiologic data;ethnic difference;Ethnic Origin;Ethnic Population;Etiology;Exposure to;Foundations;Fracture;Gene Proteins;Genes;Genetic;genetic association;genetic epidemiology;genetic predictors;Genetic Research;genetic selection;genetic variant;Genetic Variation;genome wide association study;Goals;Growth;Guidelines;Health;hormone resistance;Hormone Responsive;Hypercalcemia;improved;individualized medicine;Knowledge;Learning;Life Style;Los Angeles;Measures;Mediating;Medical Genetics;Mentors;Mentorship;Metabolism;Minerals;Morbidity - disease rate;mortality;novel;Osteoclasts;Osteogenesis;Outcome;patient population;Patients;pediatric patients;Phenotype;Physiology;Population;premature;Prevalence;PTH gene;Quality of life;Race;racial difference;racial population;Receptor Gene;Recommendation;Renal Osteodystrophy;Research;Research Design;Research Personnel;response;Risk;Role;Scientist;Secondary Hyperparathyroidism;Serum;Single Nucleotide Polymorphism;skeletal;skeletal abnormality;Skeletal system;skills;Sterols;Therapeutic;Therapeutic Intervention;Time;Training;translational scientist;treatment guidelines;Universities;Variant;Vascular calcification;Vitamin D;Vitamin D-Binding Protein;Vitamin D3 Receptor;Work;young adult

PROJECT_TITLE: Vitamin D Genetics and Racial Differences in Pediatric Chronic KidneyDisease-Mineral and Bone Disorder


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: Project Narrative Adults with complex medical and social needs experience substantial health care burdens and suffer a disproportionate impact of preventable morbidity and mortality. We propose to combine advanced predictive model building with an innovative Whole Person Navigation strategy to address the social and clinical barriers to health care among patients with multiple chronic conditions at the highest risk of persistent clinical care gaps. We will test the impact of this patient-centered, integrated care navigation strategy on evidence-based care outcomes in a randomized clinical trial across two health care systems located in Northern California and Washington State.

PI_NAMEs: GRANT, RICHARD W (contact)

PROGRAM_OFFICER_NAME: SIMPSON, MATTHEW

PROJECT_TITLE: Whole Person Navigation: Pragmatic randomized trial of combined social resource and care system navigation for adults with multiple chronic conditions

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Pediatric;Prevention

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE from Parent Award (unchanged) Early recognition of signs of future mental health problems may enable low-risk interventions to prevent those outcomes. The current study uses a sample of mothers and young children to understand both the psychological features of early risk, and to clarify whether prenatal health is a modifiable factor in such risk.

PI_NAMEs: GUSTAFSSON, HANNA C (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: 3 year old;Address;Age;Biological;Brain;Child;Childhood;Clinical;Clinical assessments;Data;Development;Diagnostic;disease classification;early childhood;Early identification;Early Intervention;Emotions;Ethics;Etiology;executive function;experience;Future;immune activation;Immune system;Immunologics;infancy;Infant;Inflammation;Inflammatory;Informal Social Control;innovation;Intervention;Learning;Life;Measures;Mediating;Mental disorders;Mental Health;Methods;Molecular;Mothers;negative affect;Outcome;parent project;Pathogenesis;Phenotype;Population;Populations at Risk;Pregnancy;prenatal;prenatal health;prenatal stress;prevent;programs;prospective;psychologic;Psychoneuroimmunology;Psychopathology;Research;responsible research conduct;Risk;Role;Sampling;Signal Transduction;skills;symptomatology;Symptoms;Testing;theories;Training;Training Activity;Translating;Work;Writing

PROJECT_TITLE: Supplement to Prenatal and Early Life Predictors of Child Psychopathology


ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative There is no change, for this section, from the original proposal. Therefore nothing is required here.

PI_NAMEs: MEVERS, EMILY ELIZABETH (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TITLE: Unlocking the biomedical potential of microbial symbionts from complex ecosystems; Admin Supplement for Instrumentation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


NIH_SPENDING_CATS: Genetics

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE The capability of a cell to divide relies on its ability to produce proteins and is directly related to the production of ribosomes in the nucleolus. We seek to understand the role of a novel complex that we found to be involved in maintaining nucleolar integrity, protein synthesis, and cell growth.

PI_NAMEs: CONACCI-SORRELL, MARALICE  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Alzheimer's Disease;Architecture;Binding;Biogenesis;Cell Cycle;cell growth;Cell Nucleolus;Cells;Complex;Data;Defect;Development;Disease;Experimental Designs;Fingers;Generations;Genetic Transcription;Health;human disease;Immunoprecipitation;In Vitro;in vivo;knock-down;Knock-out;Maintenance;Malignant Neoplasms;Mammalian Cell;Measures;Membrane;Molecular;Morphology;Names;Neurodegenerative Disorders;novel;novel strategies;NPM1 gene;Nucleolar Proteins;Organelles;overexpression;Parkinson Disease;Pathologist;Pathway interactions;Point Mutation;Production;Property;Protein Biosynthesis;Proteins;recruit;Regulation;Research;Ribosomal Proteins;Ribosomal RNA;Ribosomes;RNA;RNA Processing;Role;self organization;Seminal;Signal Transduction;Solid Neoplasm;Specific qualifier value;Structure;Testing;Translations;Work;Yeasts;Zinc Fingers

PROJECT_TITLE: Uncovering novel players in nucleolar organization and function

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Pediatric;Suicide;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Preteen girls are experiencing unprecedented rates of depression and suicidal thoughts and understanding social dynamics that arise in preteen girls’ social media use, including the temporal unfolding of rejection, is critical to uncovering mechanisms of mental health susceptibility to social media experiences at this pivotal developmental stage. This study will use multiple methods to assess social media behaviors and online rejection experiences in preteen girls and investigate 1) bidirectional relations between mental health and these social media experiences, 2) high rejection sensitivity as a risk mechanism predisposing some girls to experience worsening mental health in the context of online rejection, and 3) puberty as a window of vulnerability to negative mental health effects of social media. The knowledge gained from this study will inform the development of novel interventions and media guidelines aimed at reducing the negative impacts of social media engagement on mental health in preteen girls.

PI_NAMEs: LUKING, KATHERINE ROSE;WHALEN, DIANA J (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TITLE: Rejection Sensitivity and Puberty in Mental Health Vulnerability to Social Media Experiences in Early Adolescent Girls

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-R (05)]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Palliative Care

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE This research will provide critical information about private equity firms' acquisitions of assisted living, and the impact of these acquisitions on older adults needing long-term care in these settings, including the growing population with Alzheimer's disease-related dementias (ADRD). This research is aligned with NIA's goal to improve the health and well-being of older people and will accelerate progress on meeting Goal 2 of the National Plan to Address Alzheimer's Disease to "enhance care quality and efficiency" for people with ADRD.

PI_NAMEs: RAHMAN, MD MOMOTAZUR;THOMAS, KALI ST. MARIE (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Acceleration;Accident and Emergency department;Address;Adult;Advocate;Alzheimer's Disease;Alzheimer's disease related dementia;Assisted Living Facilities;beneficiary;Capital;care recipients;Caring;Characteristics;community living;Complex;Consensus;Data;Dementia;dementia care;design;disabled;Environment;Equity;Functional impairment;Goals;Health;Health Care Sector;Heterogeneity;Hospitalization;Housing;Human Resources;improved;Individual;Industry;insight;Interview;Investments;Lawyers;Licensing;Literature;Long-Term Care;Marketing;Medicare;meetings;memory care;Methods;Monitor;mortality;Negative Finding;new technology;Nursing Homes;older adult;Older Population;operation;Outcome;Ownership;Patients;payment;Perception;Personal Satisfaction;Persons;Policies;Policy Maker;Population;Prevalence;Privatization;Provider;Qualifying;Quality of Care;Regulation;Reporting;Research;Services;Structure;Testing;treatment effect;Update;welfare;Work

PROJECT_TITLE: Private Equity Expansion in Assisted Living: Implications for Dementia Care

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE There an urgent need for new effective treatments to decrease the toll that opioid use disorder takes on individuals and society. The experimental medication psilocybin has produced positive results in early-stage clinical trials using it to treat alcohol use disorder and depression, but it has not yet been tested in opioid use disorder. This study investigates whether psilocybin can help patients in opioid use disorder treatment stop using illicit opioids.

PI_NAMEs: BOGENSCHUTZ, MICHAEL PARKS (contact)

PROGRAM_OFFICER_NAME: RAMEY, TANYA S

PROJECT_TERMS: Abstinence;active method;addiction;Adherence;Aftercare;Agonist;alcohol use disorder;antidepressant effect;Back;Characteristics;Clinical;Clinical Data;clinical effect;Clinical Research;clinically relevant;Cocaine use disorder;craving;Data;Data Collection;Death Rate;design;dosage;Dose;Double-Blind Method;Double-blind trial;drinking;drug development;Drug Screening;Drug Targeting;Drug usage;effective therapy;efficacy outcomes;efficacy testing;efficacy trial;Evaluation;Fentanyl;follow-up;functional outcomes;Hallucinogens;illicit opioid;improved;Impulsivity;Individual;innovation;Machine Learning;machine learning algorithm;Manuals;marginalized community;marginalized population;Measures;member;Mental Depression;Methadone;methadone treatment;Methods;minority communities;Minority Groups;Modeling;negative affect;New Mexico;New York;Opioid;opioid treatment program;opioid use;opioid use disorder;Outcome;overdose death;Participant;Patient Self-Report;Patients;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;Placebos;Prediction of Response to Therapy;primary outcome;Program Development;Psilocybin;Psychotherapy;Publishing;Questionnaires;random forest;Randomized;recruit;Reporting;Research;ROC Curve;Safety;safety outcomes;Sampling;Serotonin Receptor 5-HT2A;Signal Transduction;Societies;Specific qualifier value;Statistical Data Interpretation;Substance Use Disorder;substance use treatment;synthetic opioid;Testing;timeline;Tobacco Use Disorder;Training;treatment group;Treatment outcome;treatment program;Urine

PROJECT_TITLE: Evaluation of psilocybin as an adjunctive treatment for opioid use disorder in methadone-maintained patients who continue to use illicit opioids

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SXC-M (O1)]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health;Violence Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Project Narrative advancing CSA from constituents system-embedded This project seeks to improve health and wellbeing f children affected by child sexual abuse ( CSA) by the targeted prevention of recurrent CSA. It does so first by illuminating the multilevel etiology of recurrence through curation and analysis of a comprehensive, integrated dataset of CSA in Philadelphia 2013-2021. Interpretation of these findings will then be enriched via qualitative interviews with throughout the child welfare system, leading to the conceptualization of novel child welfare targeted prevention models to reduce CSA recurrence. o

PI_NAMEs: KOBULSKY, JULIA  (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: Administrator;adverse childhood events;Affect;Budgets;Caregivers;Case Management;Characteristics;Child;Child Advocacy;child protective service;Child Sexual Abuse;Child Welfare;cost effective;Data;Data Element;data integration;Data Science;Data Set;design;Development;Domestic Violence;Emotional;Etiology;evidence base;Family;Female;frailty;Geography;Goals;Grant;Guide prevention;Health;health care availability;health equity;Health Service Area;Human;improved;Incidence;insight;Interview;Knowledge;Law Enforcement;Life Cycle Stages;life span;Link;longitudinal dataset;male;Mental disorders;Mental Health;Methods;Modeling;multidisciplinary;Natural Language Processing;Neighborhoods;novel;perpetrators;Personal Satisfaction;Philadelphia;Positioning Attribute;Poverty;Prevalence;prevent;Prevention;Prevention approach;Prevention strategy;protective factors;psychosocial;Recurrence;recurrence prevention;Research;Research Personnel;Resources;response;Risk;Risk Factors;Risk Taking;service providers;Services;social health determinants;Substance abuse problem;substance use;Suicide attempt;Survival Analysis;Survivors;System;Techniques;tertiary prevention;Text;Theoretical model;Time;Trauma;United States National Institutes of Health;Universities;Victimization

PROJECT_TITLE: Never Again: Advancing the Prevention of Recurrent Child Sexual Abuse

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MOSCOW

ORG_NAME: UNIVERSITY OF IDAHO

ORG_STATE: ID

PHR: PROJECT NARRATIVE This Team Science administrative supplement will contribute to the Idaho INBRE-4 Program goal to increase the state’s competitiveness in biomedical research and education. The research will generate, complement, and enrich Idaho’s research capacity with new investigators, cross-disciplinary collaborations, and intensive research opportunities for students.

PI_NAMEs: BOHACH, CAROLYN HOVDE (contact)

PROJECT_TERMS: 3-Dimensional;Address;Adhesions;Administrative Supplement;Area;Binding Sites;Biochemical;Biocompatible Materials;biocompatible polymer;Biomedical Engineering;Biomedical Research;bone;cadherin-11;Cell Adhesion;Cell-Cell Adhesion;Cells;Chemical Engineering;Chemicals;Chemistry;Clinical;Collaborations;Collagen;Complement;crosslink;Crosslinker;Cues;Custom;Data;density;design;Development;Education;Elastic Tissue;Elasticity;Embryo;Encapsulated;Engineering;Environment;Extracellular Matrix;Extracellular Matrix Proteins;factor A;Family;Fibronectins;Funding;Goals;graduate student;Growth;Growth Factor;healing;Hydrogels;Idaho;In Vitro;in vivo;Individual;Injury;Intercellular Junctions;Knowledge;Link;loss of function;mechanical force;mechanical properties;mechanical signal;mechanical stimulus;Mechanics;Mesenchymal Stem Cells;Modeling;Modulus;Mus;Muscle;Musculoskeletal;N-Cadherin;Natural regeneration;novel;Organic Chemistry;parent grant;Peptide Signal Sequences;Peptide Synthesis;Peptides;peptidomimetics;Performance;Permeability;Persons;physical property;Polymers;postnatal;Production;programs;protein aminoacid sequence;Proteins;rational design;regenerative therapy;Research;Research Personnel;Role;Science;Series;Side;Signal Transduction;Site;stem cell differentiation;stem cells;Students;Synthesis Chemistry;System;tendon development;Tendon Injuries;Tendon structure;Testing;theories;Tissues;Training;undergraduate student;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Idaho INBRE Program


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Physical Rehabilitation;Rehabilitation

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it considers how psychological and perceptual factors may complement conventional uses of non-invasive brain stimulation for enhancing motor learning. By doing so, new horizons can then be pursued that leverage biological, behavioral, social, and environmental factors to maximize the benefits of tDCS through a whole person health approach. Thus, the proposed research is relevant to the vision of NCCIH by advancing integrative health within neurorehabilitation and beyond.

PI_NAMEs: SCHAEFER, SYDNEY YOSHIE (contact)

PROGRAM_OFFICER_NAME: QUINLAN, ERIN BURKE

PROJECT_TERMS: Adjuvant Therapy;Adopted;Affect;Anxiety;Behavioral;Behavioral Sciences;Belief;Biological;Brain;Clinical;clinical practice;Cognition;Complement;Consensus;Control Groups;Data;Devices;Double-Blind Method;Dropout;Electric Stimulation;Enrollment;Environmental Risk Factor;expectation;experience;Exposure to;Failure;follow-up;Future;General Population;Goals;Health;Healthcare;improved;Individual;Individual Differences;innovation;Integrative Medicine;Interdisciplinary Study;Knowledge;Learning;learning outcome;Learning Skill;Masks;Measures;mind body interaction;Motor;motor learning;motor rehabilitation;motor skill learning;Motor Skills;multimodality;National Center for Complementary and Integrative Health;neurological rehabilitation;noninvasive brain stimulation;Outcome;Pain;pain relief;Paper;Participant;Perception;Performance;person centered;Persons;Pharmacological Treatment;Physical therapy;Placebo Effect;Placebos;Play;primary outcome;psychologic;Public Health;regenerative treatment;Rehabilitation therapy;Reporting;Reproducibility;Research;Research Design;Research Priority;Role;Sample Size;Sampling;Scalp structure;secondary analysis;secondary outcome;Sensorimotor functions;skills;skills training;social factors;Social Sciences;Standardization;success;Techniques;Testing;Time;Training;transcranial direct current stimulation;treatment and outcome;treatment effect;United States National Institutes of Health;Variant;Vision;whole health;Work

PROJECT_TITLE: Measuring Expectancy Effects of Transcranial Direct Current Stimulation on Motor Learning


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Regenerative Medicine;Social Determinants of Health

ORG_CITY: WORCESTER

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: WORCESTER POLYTECHNIC INSTITUTE

ORG_STATE: MA

PHR: Project narrative Tissue engineered heart valves (TEHVs), which have the potential to self-repair and grow with the patient, are a promising alternative to current valve replacements, especially for pediatric patients. Yet TEHVs decellularized prior to implantation to minimize the immune response rely on repopulation of the matrix with host cells to facilitate remodeling of the matrix. The proposed project will determine how the dynamic mechanical environment of the valve regulates the attachment, infiltration, and differentiation of host cells into the TEHV matrix with the goal of optimizing TEHV design for host cell repopulation and adaptive remodeling under complex in vivo conditions.

PI_NAMEs: BILLIAR, KRISTEN L (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: 3-Dimensional;Adhesions;Apoptosis;Biopolymers;Blood Vessels;cardiac tissue engineering;Cell-Matrix Junction;Cells;Complex;design;Development;Endothelium;Environment;Fibroblasts;Goals;Heart Valves;Immune response;implantation;In Situ;in vivo;Infiltration;Invaded;Liquid substance;marginalized community;Mechanics;Mentors;Mesenchymal;Microfluidics;Monitor;parent grant;Patients;pediatric patients;Periodicity;Phenotype;Population;Proliferating;Proteins;repaired;response;scaffold;shear stress;Signal Transduction;Signal Transduction Pathway;Stretching;Students;Testing;Time;Tissue Engineering;Tissues;Transforming Growth Factor beta;valve replacement

PROJECT_TITLE: The mechanics of host cell repopulation of engineered tissues


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Aurora

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: SHORT NARRATIVE This innovative mixed-methods study will examine how stress gets “under the skin” during childhood and leads to obesity and emerging cardiovascular disease risk (CVD) in adolescence. This study has two main components including an epidemiological cohort study (n=1307) and an embedded ecological momentary assessment sub-sample (n=627) with diverse parent/child (ages 5-16) dyads. The main aims of the study are to: (1) comprehensively examine the mechanistic pathways through which multi-level psychosocial stressors, biological factors, and behavioral factors interact to influence weight and emerging CVD in childhood and adolescence and (2) identify modifiable factors to disrupt these pathways and inform multi-level interventions.

PI_NAMEs: BERGE, JERICA M (contact)

PROGRAM_OFFICER_NAME: PRATT, CHARLOTTE A

PROJECT_TERMS: Accelerometer;Adolescence;Adolescent;Adult;Affect;African American;Age;American;American Psychological Association;arterial stiffness;Behavioral;Biological;Biological Factors;Biological Markers;Blood Pressure;Body Composition;Body mass index;Cardiovascular Diseases;cardiovascular disorder risk;Child;Child Behavior;Child Health;Child Rearing;Childhood;Cohort Studies;COVID-19;Data;Data Collection;design;Development;Diet;dietary;Dimensions;Disadvantaged;Disease;Disparity;early experience;Ecological momentary assessment;Epidemiology;Ethnic Origin;Ethnic Population;experience;Exposure to;Family;Family Life Cycle;feeding;Field Reports;Focus Groups;follow-up;Frequencies;Hair;Heart Rate;high risk;Hispanic;Household;human centered design;Hydrocortisone;hypothalamic-pituitary-adrenal axis;Immigrant;improved;indexing;Individual;innovation;Interruption;Intervention;Journals;Lead;Life Cycle Stages;Measures;Methods;middle childhood;Minority Groups;Native Americans;Neighborhoods;novel;Obesity;obesity in children;obesity risk;Parents;Pathway interactions;Phase;Politics;Process;prospective;Psychosocial Stress;psychosocial stressors;Puberty;Public Health;Race;racial disparity;racial health disparity;racial population;Refugees;Reporting;Research Personnel;resilience;retention rate;risk mitigation;Role;Severities;Skin;Stress;Structural Racism;Surveys;Time;United States National Institutes of Health;waist circumference;Weight

PROJECT_TITLE: Examining How Psychosocial Stress Gets "Under the Skin" and Leads to Cardiovascular Disease Risk in Diverse Children: A Mixed-Methods Study

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse

PHR: PROJECT NARRATIVE This study seeks to meaningfully address the U.S. opioid epidemic by implementing evidence-based treatment in correctional settings by comparing the effectiveness of two medications used to treat opioid use disorder, extended-release buprenorphine (XR-B) vs. extended-release naltrexone (XR-NTX), among adults currently incarcerated in U.S. jails and prisons at 5 distinct trial sites. This study will allow providers, correctional and public health authorities, payers and policy makers’ timely and relevant data to assess the effectiveness of XR-B (as well as XR-NTX) as a potentially useful re-entry treatment option considering the majority of opioid users leaving jail or prison will inevitably return to their homes and communities untreated and prone to relapse. We believe findings from with important implications for limiting the greater public safety and societal costs of heroin, fentanyl, and prescription opioid addictions.

PI_NAMEs: FARABEE, DAVID J;GRYCZYNSKI, JAN ;LEE, JOSHUA D (contact);MARSCH, LISA A.;SPRINGER, SANDRA ANN;WADDELL, ELIZABETH NEEDHAM

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Address;Adherence;Adopted;Adult;Adverse event;alcohol and other drug;Alcohol consumption;arm;authority;Buprenorphine;Caring;Clinical Trials;Clinical Trials Network;cohort;Communities;comparative effectiveness;compare effectiveness;Connecticut;County;Criminal Justice;Data;Delaware;design;Discipline of Nursing;Dose;Drug usage;effective intervention;Effectiveness;effectiveness evaluation;Eligibility Determination;Evaluation;Event;Evidence based treatment;experience;experimental arm;Face;FDA approved;Fentanyl;follow-up;Formulation;Friends;Head;Health;Hepatitis C virus;Heroin;HIV Seropositivity;HIV/HCV;Home;Hour;Human Resources;Imprisonment;improved;Individual;Injectable;Injections;Intervention;Jail;Location;Longterm Follow-up;Maintenance;Medical;medical schools;Methadone;Municipalities;Naltrexone;National Institute of Drug Abuse;New Hampshire;open label;Opioid;Opioid agonist;opioid epidemic;opioid mortality;opioid use;opioid use disorder;opioid user;Oral;Oregon;Outcome;Overdose;Participant;patient population;Patient Recruitments;Patient Self-Report;Patients;patients who use opioids;Pharmaceutical Preparations;pharmacologic;Pharmacy facility;Policy Maker;Population;prescription opioid;prescription opioid addiction;pressure;primary outcome;Prisons;Probability;Provider;Public Health;Quasi-experiment;Randomized;Randomized, Controlled Trials;recruit;reincarceration;Relapse;Research Design;Research Institute;Research Personnel;Safety;Sampling;Schedule;Science;secondary outcome;Site;social stigma;societal costs;standard of care;subcutaneous;Suboxone;System;treatment as usual;Treatment outcome;trial comparing;United States National Institutes of Health;Universities;uptake;Urine;Visit;volunteer

PROJECT_TITLE: Long-acting buprenorphine vs. naltrexone opioid treatments in CJS-involved adults


PHR: PROJECT NARRATIVE Patients with dilated, nonischemic cardiomyopathy (DCM), even in the absence of severe cardiac dysfunction, may be at high risk for life-threatening ventricular arrhythmias and sudden cardiac death. LMNA mutations perturb cardiac biomechanical properties and are the #2 cause of DCMs, leading to heart failure (HF), arrhythmias, transplantation, and premature death. Since DCM caused my LMNa mutations is a disease characterized by biomechanical impairment of the heart, it is pivotal dissect the biomechanics of the disease, thus paving the way for development of novel therapeutic strategies.

PI_NAMEs: MESTRONI, LUISA  (contact);TAYLOR, MATTHEW R

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Adult;Affect;aging related disease;Arrhythmia;Atomic Force Microscopy;biomechanical test;Biomechanics;Biophysics;Cardiac;cardiac muscle disease;Cardiac Myocytes;Cardiomyopathies;Cell Death;Cell Nucleus;Cell Physiology;Cells;Cessation of life;Cytoskeleton;Defibrillators;Development;Disease;Engineering;env Gene Products;Exposure to;Gene Expression;Genes;Genetic;Guidelines;Heart;Heart failure;Heart Transplantation;Hereditary Disease;high risk;Impairment;implantation;inherited cardiomyopathy;insight;lamin C;Lamin Type A;Lamins;Life;Malignant - descriptor;Mechanical Stress;Mechanics;Medical;Metabolic Diseases;Morbidity - disease rate;Movement;Mutate;Mutation;Myocardial dysfunction;Myocardium;neuromuscular;novel;novel therapeutic intervention;novel therapeutics;Nuclear;Nuclear Envelope;Pathology;Pathway interactions;Patients;Persons;Phenotype;premature;Premature aging syndrome;prevent;Property;Proteins;Skeletal Muscle;social;spheroids;sudden cardiac death;Tissues;transmission process;Transplantation;Ventricular Arrhythmia;Work

PROJECT_TITLE: Engineering Cardiac spheroids to study Laminopathies

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Mucin proteins comprise mucus, which coats the surface of all epithelial cells for hydration and pathogen defense. Diverse viruses have evolved to attach directly to mucins, but due to varied mucin forms, molecular details of binding preferences and their outcomes on viral evolution, diffusion, tissue specificity, and replication are lacking. We will develop synthetic mucins of precisely defined structure to unravel how viruses interact with host cell surfaces, which will improve our understanding of viral diseases and open doors to new therapeutics.

PI_NAMEs: KRAMER, JESSICA  (contact)

PROJECT_TERMS: Adhesions;Amino Acids;Anti-viral Agents;Binding;Biology;biophysical properties;Cell surface;Cells;chemical property;citizen science;Complex;Development;Diet;Diffusion;Disease;disease transmission;Drug Delivery Systems;Engineering;Epithelial Cells;Epithelium;equity, diversity, and inclusion;Evolution;Funding Opportunities;Future;Glycocalyx;Glycoproteins;glycosylation;Health;Heterogeneity;Host Defense;Human;Hydration status;Immunity;improved;Infection;Jellyfish;Knowledge;Life;Life Cycle Stages;Lubrication;Malignant Neoplasms;Mentors;Modeling;Molecular;Molecular Weight;Mucins;Mucous body substance;novel therapeutics;nutrient absorption;Outcome;pathogen;Pathway interactions;Pattern;Peptides;Play;polymerization;Polymers;polypeptide;Polysaccharides;preference;Prevention strategy;Proteins;response;Role;Sialic Acids;Specificity;Structure;sugar;surface coating;tissue tropism;Tissues;Underrepresented Populations;Vertebral column;Viral;Viral Genes;Virus;Virus Diseases

PROJECT_TITLE: Synthetic mucins in epithelial models to probe virus-mucin interactions


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biodefense and Related Countermeasures;Brain Disorders;Dementia;Emerging Infectious Diseases;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: In this research project, we will elucidate the pathway by which nonpathogenic cellular prion protein (PrPC) ex- presses anti-inflammatory activity in the CNS, determine the role of LRP1 as a mediator of this activity, test whether PrPC regulates neuro-inflammation in mouse models of neurodegenerative diseases, and determine whether the activity of the PrPC-LRP1 system may be augmented therapeutically to control neuro-inflammation in neurodegenerative diseases.

PI_NAMEs: GONIAS, STEVEN L. (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: Address;alpha synuclein;Alzheimer's Disease;Amyloid beta-Protein;Amyotrophic Lateral Sclerosis;Anti-Inflammatory Agents;Astrocytes;Attenuated;autocrine;Binding;Biological Markers;Biological Models;Blood;Blood - brain barrier anatomy;Brain;Carrier Proteins;Cause of Death;Cell Communication;Cells;Cerebrospinal Fluid;Cessation of life;Chronic;Communication;Data;Disease Progression;drug discovery;Equus caballus;exosome;Experimental Autoimmune Encephalomyelitis;Extracellular Space;extracellular vesicles;Family;Gene Deletion;gene product;glial activation;Goals;GPI Membrane Anchors;Huntington Disease;Infectious Agent;Inflammation;Inflammation Mediators;Inflammatory Response;inhibitor;Injections;Ischemic Brain Injury;Knockout Mice;LDL-Receptor Related Protein 1;Ligands;Macrophage;MAPT gene;Mediating;Mediator;Membrane Proteins;Microglia;Molecular Conformation;mouse model;Mus;Myeloid Cells;N-Methyl-D-Aspartate Receptors;Natural Immunity;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;Neuronal Dysfunction;Neurons;novel;novel therapeutic intervention;novel therapeutics;paracrine;Parkinson Disease;Pathogenicity;Pathway interactions;Pattern recognition receptor;Peptide Hydrolases;Peptides;Physiological;Population;pre-formed fibril;Process;Production;protein aggregation;Proteins;PrP;PrP gene;Publishing;receptor;Regulation;Research Project Grants;response;Role;Signal Pathway;Signal Transduction;Structure;synthetic peptide;System;tau Proteins;Tauopathies;Testing;Therapeutic;therapeutic candidate;therapeutic development;Tissues;Transgenic Mice;Wild Type Mouse

PROJECT_TITLE: Regulation of Neurodegeneration by Nonpathogenic Cellular Prion Protein and LRP1

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: NOVATO

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

PHR: OVERALL PROJECT NARRATIVE  Age is the most important risk factor for developing Alzheimer’s disease and related dementias, but the mechanisms and development of successful treatments remain elusive. We propose to determine how age- related changes in both neurons and non-neuronal brain cells can drive these pathologies, with the long term goal of using these insights into effective interventions.

PI_NAMEs: ELLERBY, LISA M (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: 3-Dimensional;Affect;Age;age related;age related changes;age related neurodegeneration;Age-associated memory impairment;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Applications Grants;Astrocytes;Automobile Driving;Bioinformatics;Brain;brain cell;Cell Aging;Cell Communication;Cell Culture Techniques;Cell Death;cell type;Cells;Clinical;Collaborations;cost;Data;Dementia;Development;Disease;Disease Progression;Economics;effective intervention;effective therapy;Emotional;Endothelial Cells;Etiology;Family;Goals;Head;Human;induced pluripotent stem cell;Inflammation;insight;interest;Intervention;Knowledge;Macrophage;member;Metabolic;Metabolism;metabolome;Modeling;Molecular;mouse model;Mus;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;Neurons;novel;novel strategies;Oligodendroglia;Organoids;Pathology;Patients;Pharmaceutical Preparations;Phenotype;Population;Productivity;Program Research Project Grants;programs;Proteome;Proteomics;Publishing;Recording of previous events;Research;Research Personnel;Research Project Grants;response;Risk;Risk Factors;Role;senescence;senescent cell;senolytics;social;Testing;Time;transcriptomics;Translating

PROJECT_TITLE: Cellular senescence and cell fate/interactions as drivers of Alzheimer's and age-related dementias


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Epilepsy;Neurodegenerative;Neurosciences;Pediatric

ORG_NAME: TURING MEDICAL TECHNOLOGIES INC

PHR: Project Narrative In children, clinical functional MRI (fMRI) has extremely high fail rates (50-90%) due to excessive head motion and task non-compliance. Despite FDA clearance for neurosurgical planning, the low quality of pediatric fMRI mapping is limiting its use, thus increasing discomfort and the risk of cognitive, language and motor deficits. This psychological technology application overcomes the current insufficiencies of non-invasive pediatric fMRI with FIRMM Qx, a real-time motion and compliance tracking software that uses neuro-developmentally targeted, gamified biofeedback to improve fMRI brain mapping and thus neurosurgical safety for children.

PI_NAMEs: FAIR, DAMIEN A;KING, KEVIN  (contact);ROLAND, JAROD

PROGRAM_OFFICER_NAME: CAPORELLO, EMILY LAURA

PROJECT_TERMS: Aphasia;Attention deficit hyperactivity disorder;awake;base;Behavioral;Biofeedback;Brain;Brain Mapping;Brain region;Child;Childhood;childhood epilepsy;clinic ready;Clinical;Cognitive deficits;cohort;Complex;Computer software;Consumption;Data;data quality;Development;developmental psychology;Dreams;Effectiveness;Electric Stimulation;Enrollment;Environment;Epilepsy;Excision;experience;Failure;Feedback;Fingers;Functional Magnetic Resonance Imaging;Funding;Hand;Head;Image;improved;Individual;Informal Social Control;innovation;Institution;Interruption;Intervention;Intractable Epilepsy;Language;Language Disorders;Letters;Magnetic Resonance Imaging;Maps;Marketing;Measures;Medical;Monitor;mortality;Motion;Motor;motor deficit;Movement;Names;neurodevelopment;Neurodevelopmental Deficit;neurosurgery;non-compliance;novel;Operative Surgical Procedures;Outcome;Paralysed;Patients;pediatric patients;Pediatrics;Phase;Physicians;psychologic;Research;Rewards;Risk;Running;Safety;Scanning;Schedule;Seizures;Signal Transduction;Small Business Innovation Research Grant;Small Business Technology Transfer Research;Speech;success;Surgeon;Technology;Testing;Time;tool;Update;usability

PROJECT_TITLE: Behavioral feedback and rewards for improving functional brain mapping in presurgical pediatric patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-Z(10)]


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE This revision for the UCSF-Bay Area CFAR aims to strengthen our support for diverse researchers or disparity- based research in HIV studies, fostering a pipeline of skilled investigators addressing health disparities in HIV- affected populations. These initiatives include the CFAR Diversity, Equity, and Inclusion Pathway Initiative (CDEIPI) Scholars’ program (a mentored summer research internship for undergraduate/masters’ level students), a Mentoring the Mentors training program for early career investigators from underrepresented backgrounds, and a career development award program for early-career faculty working with diverse populations or from underrepresented backgrounds themselves. By promoting inclusivity in the HIV research pipeline, our CFAR can help contribute to better health outcomes for people living with HIV.

PI_NAMEs: GANDHI, MONICA  (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Address;Affect;Area;Award;Behavior;biobehavior;Bioinformatics;Biological Markers;Biometry;career;career development;Clinical;cohort;Communities;community engagement;Consultations;Country;Development;disadvantaged background;Disparity;Diverse Workforce;early-career faculty;Educational workshop;Ensure;Epidemic;equity, diversity, and inclusion;Evaluation;experience;Faculty;Feedback;Fostering;Funding;Goals;graduate student;Grant;Health;health disparity;health equity;HIV;Housing;implementation science;improved;Individual;Inequity;Infrastructure;innovation;Institution;Interdisciplinary Study;International;Internships;intersectionality;K-Series Research Career Programs;Leadership;meetings;Mentors;minority investigator;Minority-Serving Institution;Outcome;Participant;Pathway interactions;Persons;Population;Population Heterogeneity;Postdoctoral Fellow;pre-exposure prophylaxis;Prevention;Productivity;Program Development;programs;Publications;referral services;Research;Research Activity;Research Personnel;Resources;response;Risk;San Francisco;Scholars Program;Service provision;skills;Students;substance use;success;summer research;Techniques;Time;tool;Training;Training Programs;undergraduate student;Underrepresented Minority;Vulnerable Populations;Work;working group

PROJECT_TITLE: Support of Diversity Initiatives in the UCSF-Bay Area CFAR: Developing HIV Researchers from Pipeline to Early Career Faculty

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 SA-A (S1)]


PHR: Project Narrative - Core Please refer to the Overall section.

PROJECT_TERMS: Academia;academic standard;Acquired Immunodeficiency Syndrome;Address;Advocate;Area;Asian Americans;Award;career;career development;Career Mobility;cohort;design;Development;disadvantaged background;Diverse Workforce;early-career faculty;Educational workshop;Enrollment;Ensure;equity, diversity, and inclusion;experience;Funding;Future;graduate student;Grant;Health;Hispanic;HIV;improved;Infrastructure;Institution;interest;Internships;Joints;K-Series Research Career Programs;medical schools;member;Mentors;Minority;minority communities;Minority Groups;minority investigator;Minority-Serving Institution;Modification;Native Americans;Outcome;Pacific Island Americans;parent grant;Parents;Participant;Pathway interactions;Phase Transition;Population Heterogeneity;Postdoctoral Fellow;professor;Program Development;Program Evaluation;programs;Publications;Research;Research Institute;Research Personnel;Running;San Francisco;Scholars Program;Scholarship;skill acquisition;Students;success;summer program;summer research;systemic barrier;Taxes;Techniques;Time;tool;Training;Training Programs;undergraduate student;Underrepresented Minority;Universities;Work;working group

PROJECT_TITLE: Support of Diversity Initiatives in the UCSF-Bay Area CFAR: Developing HIV Researchers from Pipeline to Early Career Faculty (Revision to Developmental Core)


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

ORG_CITY: ROCKVILLE

ORG_NAME: THE EMMES COMPANY, LLC

PI_NAMEs: EWELL, MARIAN  (contact)

PROJECT_TERMS: Clinical Research;Clinical Trials;Communicable Diseases;Consultations;Contractor;Control Groups;Data Analyses;Data Collection;Data Coordinating Center;data management;data quality;electronic data;Internet;Quality Control;Randomized;Research Design;Sample Size;Specimen;statistics;Stratification;System

PROJECT_TITLE: Statistical and Data Coordinating Center (SDCC) for Clinical Research in Infectious Diseases


NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Infectious Diseases

PROJECT_TERMS: Antimicrobial Resistance;Bacterial Drug Resistance;Clinical Trials;Combating Antibiotic Resistant Bacteria;Consultations;Contractor;Control Groups;Data Analyses;Data Collection;Data Coordinating Center;data management;data quality;electronic data;Gram-Negative Bacteria;Gram-Positive Bacteria;Internet;Quality Control;Randomized;Research Design;Sample Size;Specimen;statistics;Stratification;System

PROJECT_TITLE: Statistical and Data Coordinating Center: Antibacterial Resistance Studies