NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Influenza;Orphan Drug;Pneumonia and Influenza;Prevention;Rare Diseases;Vaccine Related

PI_NAMEs: MARZI, ANDREA  (contact)

PROJECT_TERMS: Action Potentials;Adenoviruses;Aerosols;Africa;Alpha Virus;Animal Disease Models;Animal Model;Animals;Anti-viral Therapy;Antigens;B-Cell Activation;Bacille Calmette-Guerin vaccination;Blood;Blood specimen;Cavia;Cells;Chiroptera;Clinical;cohort;Collaborations;comparative;Containment;Cote d'Ivoire Ebola virus;cross immunity;cross reactivity;Data;Development;Disease;disease model;Disease Outbreaks;Disease Progression;Dose;Eastern Africa;Ebola Vaccines;Ebola virus;efficacy study;Emerging Communicable Diseases;emerging virus;Equatorial Guinea;Euthanasia;Evaluation;Exhibits;exposure route;Ferrets;Fever;Filovirus;forest;Future;genetic approach;Genetic Transcription;Genomics;Ghana;Glycoproteins;Guinea;guinea pig model;Hamsters;Human;Hungary;Immune response;Immunobiology;immunogenicity;Immunoglobulin G;improved;Infection;Inflammation Mediators;Influenza A virus;Influenza A Virus, H5N1 Subtype;innovation;Institution;Intramuscular;Intranasal Administration;Kentucky;Knockout Mice;Knowledge;Kyasanur Forest disease virus;Laboratories;Legal patent;Licensing;Link;longitudinal analysis;Lung;Macaca;Macaca fascicularis;Manuscripts;Maps;Marburg Virus Disease;Marburgvirus;Microbe;Modeling;Molecular Virology;Mucous Membrane;Mus;National Institute of Allergy and Infectious Disease;neutralizing antibody;North Carolina;novel;Pan Genus;pathogen;Pathogenesis;pathogenic virus;Pathway interactions;pre-clinical;Predisposition;Preparation;protective efficacy;Public Health;public health emergency;Replicon;Research;response;reverse genetics;RNA;Rodent;Route;seroconversion;Severity of illness;Sudan Ebola virus;Tanzania;Therapeutic;Thrombocytopenia;Translations;TRIM5 gene;Uganda;United States National Institutes of Health;Vaccinated;Vaccination;vaccination outcome;vaccine development;vaccine efficacy;vaccine immunogenicity;vaccine platform;vaccine trial;Vaccines;Vesicular stomatitis Indiana virus;Viral;Viral Antigens;Viral Genes;Viremia;Virulence Factors;Virus;Virus Diseases;Virus Replication;Virus Shedding;Whole Blood

PROJECT_TITLE: Immunobiology, molecular virology and countermeasures of highly pathogenic viruses


ACTIVITY: ZIA

ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Microbiome

PI_NAMEs: LOKE, P'NG  (contact)

PROJECT_TERMS: Affect;B-Lymphocytes;Blood;Clinical;Clinical Research;co-infection;Collaborations;Complex;Computational Biology;cytokine;Data;Diet;Disease;Environment;environmental change;Environmental Risk Factor;Equilibrium;field study;Future;Gene Expression Profile;Genetic;Genetic Variation;Genomics;Genotype;Goals;gut microbiome;helminth infection;Heterogeneity;High Prevalence;Homeostasis;Immune;Immune response;Immunity;Immunologics;Inbred Strains Mice;Individual;Infection;insight;inter-individual variation;Laboratories;large datasets;Maintenance;Malaysia;Metagenomics;metatranscriptomics;microbial;microbial community;microbiome;microbiota;Molecular;mouse model;Mucosal Immune Responses;mucosal site;Mucous Membrane;Mus;Mycoses;Native-Born;Parasites;Parasitic infection;Pathology;Phenotype;Regulation;research study;Resources;response;Sampling;Site;skin microbiome;System;T-Lymphocyte;Technology;Tissues;Translational Research;Trichuris;Universities;Urbanization;Variant;virome

PROJECT_TITLE: Regulation of mucosal immune responses by helminth infections


ORG_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

PROJECT_TERMS: Acute;Adopted;Affect;B-Lymphocytes;BCL6 gene;Behavior;BIRC5 gene;CD4 Positive T Lymphocytes;cell type;Cells;chromatin remodeling;Chronic;chronic infection;chronic inflammatory disease;cytokine;Disease;Epigenetic Process;Equilibrium;fitness;Genetic;Genetic Variation;Goals;helminth infection;Heterogeneity;Homing;Immune;Immune response;Inbred BALB C Mice;Inbred Strains Mice;Individual;Infection;Inflammation;Inflammatory Response;Interleukin-13;Interleukin-4;Liver;Macrophage;Macrophage Activation;Maintenance;Mouse Strains;Mus;Myeloid Cells;NF-kappa B;Nippostrongylus;novel;Parasites;Pathway interactions;Phenotype;Point Mutation;Population;Production;programmed cell death protein 1;response;Role;Schistosoma mansoni;Schistosoma mansonii infection;single-cell RNA sequencing;Spleen;System;T cell response;T-Lymphocyte;Testing;tissue repair;Tissues;Translating;Work;wound;wound healing

PROJECT_TITLE: Alternatively activated macrophages during type 2 immune responses


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Hematology;Infectious Diseases;Rare Diseases

PI_NAMEs: COHEN, JEFFREY  (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;acute infection;anti-CD20;Antibodies;Antibody Response;antigen test;Antigens;B lymphoid malignancy;B-Lymphocytes;Biological Assay;Cessation of life;cohort;Collaborations;COVID-19;Disease;Dose;epidemiology study;Epitopes;Functional disorder;Goals;Hairy Cell Leukemia;hairy cell leukemia cell;Hairy Cell Leukemia Variant;Human;Immune response;Immunocompromised Host;Immunologic Markers;Immunosuppression;Infection;leukemia;Measures;Monitor;Monoclonal Antibody CD20;mortality;Nucleocapsid;Organ;Outcome;Patients;Persons;Polymerase Chain Reaction;Prevalence;prospective;Recovery;respiratory;response;Role;SARS-CoV-2 exposure;SARS-CoV-2 infection;Serology;Serology test;Symptoms;T cell response;T-Lymphocyte;Testing;Time;transmission process;Vaccination;Viral;viral detection;Virus

PROJECT_TITLE: Serologic studies of persons with COVID-19 infection


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Neurosciences;Pneumonia and Influenza;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: DE WIT, EMMIE  (contact)

PROJECT_TERMS: 2019-nCoV;adult stem cell;African Green Monkey;age related changes;Air;Alveolar;Alveolar Cell Type I;animal data;Animal Model;Animals;Area;Basal Cell;Biological Models;Blood;Brain;Cattle;Cause of Death;Cell Death Induction;cell type;Cells;Central Nervous System;Cerebrum;Cessation of life;Clinical Research;Communicable Diseases;Coronavirus;COVID-19 pandemic;COVID-19 patient;Dairying;Data;Development;Disease;Disease Progression;druggable target;effective therapy;emerging virus;Ensure;Epithelial Cells;Evolution;Exhibits;Extravasation;fitness;Gases;Goals;Histologic;Human;immune activation;Immune Evasion;in vitro Model;Individual;induced pluripotent stem cell;Infection;Inflammatory Response;Influenza A virus;Influenza A Virus, H5N1 Subtype;insight;interest;Interferons;Kinetics;Liquid substance;Lower Respiratory Tract Infection;Lower respiratory tract structure;Lung;Mesocricetus auratus;Methods;model development;Molecular;Montana;Mountain Lion;Nasal Epithelium;Nervous System Disorder;Neurologic;Neurologic Signs;Neurological Models;Neuronal Differentiation;Neuropathogenesis;Nipah Virus;Nose;Organ;Organoids;Pathogenesis;Pathogenicity;Pathway interactions;Phenotype;pneumocyte;Population;Predisposition;Procedures;Protocols documentation;Public Health;remdesivir;Respiratory Disease;Respiratory System;Respiratory Tract Diseases;respiratory virus;response;SARS-CoV-2 B.1.1.529;SARS-CoV-2 B.1.617.2;SARS-CoV-2 variant;stem cells;Syndrome;System;Therapeutic;Time;Tissues;tool;transmission process;Upper respiratory tract;Variant;variants of concern;Viral;Viral Pathogenesis;Virus;Work

PROJECT_TITLE: Emerging respiratory viruses - pathogenesis and countermeasures


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PI_NAMEs: TAN, JOSHUA  (contact)

PROJECT_TERMS: 2019-nCoV;Adjuvant;Antibodies;Antibody Response;Antigens;B-Lymphocytes;Biological Assay;Biology;Blood;Cells;Chromosomes;cohort;combat;Communicable Diseases;cost;COVID-19 pandemic;Disease;Engineering;Epitopes;Exposure to;fighting;Genes;Goals;Human;human monoclonal antibodies;Immune response;improved;in vivo;Infection;Learning;Life Cycle Stages;lonely individuals;Malaria;Monoclonal Antibodies;Mycobacterium tuberculosis;Paper;pathogen;Plasmodium;Plasmodium falciparum;prevent;Process;Prophylactic treatment;Proteins;Publishing;Reaction;Reporting;Research Project Grants;Resolution;response;Site;Somatic Mutation;Sporozoites;Structure of germinal center of lymph node;Surface;Technology;tool;Vaccinated;vaccine candidate;Vaccine Design;Vaccines;Work

PROJECT_TITLE: Human monoclonal antibodies targeting infectious pathogens


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Prevention;Rare Diseases;Rural Health;Vaccine Related;Vector-Borne Diseases;Women's Health Research

PI_NAMEs: DUFFY, PATRICK  (contact)

PROJECT_TERMS: 2019-nCoV;acute COVID-19;Adjuvant;age stratification;Antibodies;Antibody Response;Area;Blood;Blood specimen;Carrier Proteins;Clinical;Clinical Trials;Collaborations;Communities;Conceptions;Conjugate Vaccines;cost;cost effective;COVID-19;COVID-19 pandemic;COVID-19 prevalence;COVID-19 vaccine;Culicidae;Disease Surveillance;Dose;Epidemiology;Evaluation;feeding;frontier;Funding;Future;Goals;Health;Hour;Household;Human;Human Bites;human disease;Immune Sera;immunogenicity;Immunoglobulin G;Immunology procedure;improved;Individual;Laboratories;Location;low and middle-income countries;Macaca mulatta;Malaria;Mali;Manuscripts;Messenger RNA;Methods;Monitor;Mus;nonhuman primate;Outcome;pandemic disease;Participant;Penetration;performance tests;Phase;Population Surveillance;Postpartum Women;pre-pandemic;pregnant;Preparation;Production;programs;Progress Reports;Publications;Publishing;Reagent;receptor binding;Recombinants;Research;response;Rhesus;RNA vaccine;Rural;Rural Community;Rural Population;Sampling;SARS-CoV-2 antibody;SARS-CoV-2 antigen;SARS-CoV-2 B.1.1.529;Sentinel;seroconversion;Serology test;seropositive;Seroprevalences;serosurveillance;serosurvey;Site;Specificity;Time;Urban Population;vaccination outcome;vaccine candidate;vaccine development;vaccine platform;vaccine trial;Variant;Venous;Viral;viral detection;Virus

PROJECT_TITLE: COVID-19 Serosurveys and Vaccine Study Site Preparations


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related

PI_NAMEs: TOLIA, NIRAJ  (contact)

PROJECT_TERMS: 2019-nCoV;Amino Acids;Antibodies;Antibody titer measurement;Antigens;Area;B-Lymphocytes;Collaborations;COVID-19;COVID-19 vaccine;Data;design;Development;Epitopes;Generations;Goals;Human;Immune response;Immunity;improved;In Vitro;Knowledge;lead candidate;Malaria Vaccines;Methods;Modification;Molecular;Molecular Structure;nanoparticle;neutralizing antibody;next generation;nonhuman primate;novel;novel vaccines;Parents;pathogen;Production;Proteins;Publishing;receptor binding;Research;research and development;Resistance;response;Rodent;SARS-CoV-2 antigen;SARS-CoV-2 spike protein;screening;self assembly;Technology;Time;Vaccination;vaccine candidate;vaccine development;Vaccine Research;Vaccines;vaccinology;Variant;Viral;Virus;Work

PROJECT_TITLE: COVID-19 Structural Vaccinology


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Hematology;Infectious Diseases;Lung;Pulmonary Fibrosis

PI_NAMEs: SUN, PETER D. (contact)

PROJECT_TERMS: 2019-nCoV;Acute;acute COVID-19;Acute Respiratory Distress Syndrome;Anticoagulants;Blood Coagulation Factor;Blood Vessels;Breathing;Bronchoalveolar Lavage Fluid;Cell surface;Cells;Cessation of life;Clinical;Clinical Trials;Coagulation Process;COVID-19;COVID-19 mortality;COVID-19 patient;COVID-19 severity;COVID-19 susceptibility;current pandemic;Deposition;design;Epithelial Cells;experience;Fiber;Fibrin;Fibrinogen;Fibrosis;Hospitalization;Human;Individual;Infection;inhibitor;insight;interest;Liquid substance;Lung;matriptase;Mechanical ventilation;Mediating;member;Membrane;Modeling;Molecular;mortality;pandemic disease;Peptide Hydrolases;Persons;pharmacologic;Plasma;Proteomics;Prothrombin;Public Health;Pulmonary Fibrosis;Recombinants;respiratory;response;SARS-CoV-2 infection;Serine Protease;severe COVID-19;Severities;ST14 gene;Testing;Therapeutic;Thrombin;Thrombus;Trypsin;Viral;Virus Diseases

PROJECT_TITLE: Inhibition of COVID-19 associated acute fibrin deposition in lung


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Lung;Pediatric

PI_NAMEs: SU, HELEN  (contact)

PROJECT_TERMS: 2019-nCoV;acute COVID-19;adaptive immune response;Affect;Agreement;American;Americas;Autoantibodies;Biochemical;Child;Collaborations;comorbidity;Complication;consanguineous family;Convalescence;COVID-19;COVID-19 susceptibility;Defect;Development;Disease;Double-Stranded RNA;Family member;Far East;Genetic;genetic approach;Genetic Determinism;Genetic Predisposition to Disease;genetic variant;Genome;Health Sciences;Human;Human Genetics;Immune;Immune response;In Vitro;Individual;Innate Immune Response;Institutional Review Boards;Integration Host Factors;Interferons;International;Intramural Research Program;Italy;Knowledge;Life;Middle East;Molecular;molecular targeted therapies;Multisystem Inflammatory Syndrome in Children;National Institute of Allergy and Infectious Disease;NF-kappa B;Other Genetics;Outcome;Paper;participant enrollment;Pathogenesis;Pathway interactions;Patients;Persons;Population Genetics;Predisposition;Principal Investigator;Program Research Project Grants;Protocols documentation;Recording of previous events;Research;Research Personnel;respiratory;response;Role;Sampling;SARS-CoV-2 infection;sensor;severe COVID-19;Susceptibility Gene;Therapeutic Intervention;Thymus Gland;University Health Services;Validation;Variant;variant of interest;Virus;Work;Writing;young adult

PROJECT_TITLE: Host factors contributing to susceptibility to COVID-19 disease


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

PI_NAMEs: MEMOLI, MATTHEW  (contact)

PROJECT_TERMS: 2019-nCoV;Address;Affect;Antibodies;Antibody titer measurement;betacoronavirus;betacoronavirus vaccine;Biological;Clinical;Clinical Trials;Collaborations;Communities;Coronavirus;coronavirus vaccine;COVID-19;COVID-19 pandemic;Data;Data Analyses;Databases;Decision Making;design;Economics;Enrollment;Epidemiology;follow-up;Future;future pandemic;General Population;healthy volunteer;Immune response;Immunity;Individual;Infection;insight;Knowledge;large scale data;Lead;male;manufacture;Manuscripts;Modeling;Morbidity - disease rate;mortality;National Center for Advancing Translational Sciences;pandemic disease;pandemic virus;Participant;Pathogenesis;Patients;Personality;Personality Traits;Persons;Play;Population;post-pandemic;Prevalence;Production;programs;Psychology;Public Health;Publishing;Rare Diseases;response;Role;Sampling;SARS-CoV-2 infection;SARS-CoV-2 pathogenesis;serosurvey;Severities;Sex Differences;Surveys;Time;Universities;vaccine development;vaccine evaluation;Vaccines;Virus;women patients;Work

PROJECT_TITLE: Coronavirus Pathogenesis and Broadly Protective Vaccine Development


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Primary Immunodeficiencies;Rare Diseases;Vaccine Related

PROJECT_TERMS: 2019-nCoV;adaptive immune response;Cell Death;Cells;Characteristics;Clinical Data;congenital immunodeficiency;COVID-19;COVID-19 pandemic;COVID-19 patient;COVID-19 susceptibility;Databases;Disease;Disease susceptibility;drug development;Drug Targeting;Elderly;Ethnic Population;Goals;Human;Immune response;Immunologics;impaired capacity;Individual;Infection;Innate Immune Response;interest;International;Medical;Molecular;Mutation;National Institute of Allergy and Infectious Disease;new therapeutic target;Pathogenicity;Patients;Population;post SARS-CoV-2 infection;predict clinical outcome;prevent;Public Health;Research Personnel;Respiratory Failure;RNA vaccine;RNA Viruses;Sampling;SARS-CoV-2 infection;Site;Standardization;Symptoms;T cell response;Therapeutic;therapeutic target;United States National Institutes of Health;Viral Pathogenesis;Virus;Work

PROJECT_TITLE: Molecular Mechanisms of SARS-CoV-2 Infection and Therapeutic Targets


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Burden of Illness;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Patient Safety;Pediatric;Prevention;Primary Immunodeficiencies;Rare Diseases;Vaccine Related

PI_NAMEs: NOTARANGELO, LUIGI  (contact)

PROJECT_TERMS: 2019-nCoV;acute COVID-19;acute infection;adaptive immune response;Adult;Adverse event;Antibody Response;B cell repertoire;Biological;Biological Markers;biomarker identification;Blood;breakthrough infection;burden of illness;Child;Childhood;Chile;Clinical;Collaborations;congenital immunodeficiency;COVID-19 pandemic;COVID-19 susceptibility;COVID-19 vaccine;Data;Development;Disease;genetic variant;Goals;Health Personnel;Heterogeneity;Hospitalization;Immune response;Immune System Diseases;Immunologics;Incidence;Individual;Infection;Inflammation;Inflammatory Response;Italy;Laboratories;Molecular;Molecular Profiling;Multisystem Inflammatory Syndrome in Children;Outcome;Patients;Peripheral Blood Mononuclear Cell;Phenotype;Play;Research Personnel;Resolution;Risk;Risk Factors;Role;Sampling;SARS-CoV-2 infection;severe COVID-19;Severities;Severity of illness;Specimen;T-Lymphocyte;Time;United States;Vaccines

PROJECT_TITLE: Characterization of host immune responses to SARS-CoV-2


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Prevention;Vaccine Related

PI_NAMEs: TAUBENBERGER, JEFFERY  (contact)

PROJECT_TERMS: 2019-nCoV;airway epithelium;Animal Experimentation;Animals;betacoronavirus;cell injury;COVID-19 vaccine;Endothelial Cells;Epithelial Cells;Gene Expression;Goals;Histopathology;Human;human model;Immunization;Immunologic Markers;Inactivated Vaccines;Infection;inflammatory marker;Inflammatory Response;Influenza A virus;Intramuscular;Laboratory Animal Models;laboratory experiment;Lung;Molecular Analysis;Molecular Virology;Morbidity - disease rate;mortality;Neutrophil Activation;novel;novel coronavirus;novel vaccines;Organ;pandemic disease;Pathogenesis;pre-clinical;preclinical study;Pulmonary Pathology;Reporting;Research;Research Project Grants;respiratory;Role;Route;SARS-CoV-2 infection;SARS-CoV-2 pathogenesis;SARS-CoV-2 variant;severe COVID-19;Systems Biology;Thrombosis;vaccine development;Vaccines;Viral;Virus Diseases;Work

PROJECT_TITLE: SARS-CoV-2 Pathogenesis


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung

PI_NAMEs: KEHRL, JOHN H (contact)

PROJECT_TERMS: 2019-nCoV;ACE2;Affect;Affinity Chromatography;Alanine;Antibodies;Antibody Formation;Apoptosis;Autophagocytosis;B cell differentiation;B Cell Proliferation;B-Lymphocyte Subsets;B-Lymphocytes;betacoronavirus;Binding;Binding Proteins;Biological Assay;Blood;Blood Cells;Bone Marrow;C-terminal;Carbohydrates;CCL17 gene;CD8-Positive T-Lymphocytes;Cell Culture Techniques;Cell Death;Cell Line;Cell membrane;Cell Physiology;Cell Surface Receptors;Cell Survival;cell type;Cell-Mediated Cytolysis;Cells;Chemotactic Factors;Chloride Channels;Co-Immunoprecipitations;Confocal Microscopy;COVID-19;COVID-19 pathogenesis;COVID-19 patient;CXCL10 gene;Cysteine;cytokine;Disease;disulfide bond;E protein;Endoplasmic Reticulum;Endothelial Cells;env Gene Products;Enzymes;exposed human population;extracellular;extracellular vesicles;Family;Flow Cytometry;Gel Chromatography;Generations;Genes;glycosylation;Human;Human Cell Line;IgG1;IgG2;IgG3;IL6 gene;Image;Immune;Immune response;immunogenic;Immunoglobulin A;Immunoglobulin M;in vitro Model;in vivo;Individual;Inflammasome;Inflammation;Inflammatory;Injections;insight;Integral Membrane Protein;Interleukin-1;Interleukin-12;interleukin-23;Intravenous;intravital microscopy;IRF4 gene;Label;Leukocytes;Lipids;Liver;Lung;lymph nodes;Lymphatic Endothelial Cells;Macrophage;Mammalian Cell;Manuscripts;Mediating;Membrane;Membrane Proteins;Microscopy;Mitochondria;Molecular;monocyte;Morphology;Mus;Mutation;nanodisk;Natural Immunity;Necrosis;Nonstructural Protein;novel;Open Reading Frames;Oryctolagus cuniculus;overexpression;particle;Pathogenesis;Pathogenicity;Pathway interactions;Pattern;peripheral blood;Peripheral Blood Mononuclear Cell;Plasma;Plasmablast;Population;Preparation;Process;Production;Property;Protein Secretion;Protein Truncation;Proteins;Proteomics;receptor;Recombinant Proteins;Recombinants;recruit;Regulatory Element;RNA Viruses;RNF139 gene;Role;Route;SARS coronavirus;SARS-CoV-2 genome;SARS-CoV-2 spike protein;Severe Acute Respiratory Syndrome;SH2D3C gene;Signal Transduction;Spleen;Sterols;targeted treatment;Techniques;TNF gene;TNF receptor-associated factor 3;TRAF6 gene;transcription factor;transcriptome sequencing;Transfection;Transgenic Mice;ubiquitin-protein ligase;Vaccine Design;Vesicle;Viral;Virion;Virus;Virus Replication;Work;Xenopus oocyte

PROJECT_TITLE: Role of SARS-CoV-2 Spike Protein and Accessory ORFs in the immune pathogenesis of COVID-19


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Microbiome;Prevention;Rare Diseases;Vaccine Related

PROJECT_TERMS: 2019-nCoV;Ablation;ACE2;Acute Respiratory Distress Syndrome;Affect;Alveolar Macrophages;Antibodies;asymptomatic COVID-19;CD8-Positive T-Lymphocytes;CD8B1 gene;co-infection;COVID-19;COVID-19 severity;COVID-19 vaccine;Developing Countries;Disease;Disease Outcome;Enrollment;Environment;epidemiologic data;epidemiology study;Epigenetic Process;Exposure to;Genetic Transcription;Goals;helminth infection;Helminths;Household;Human;Immune response;Immune system;Immunologics;immunoregulation;India;Individual;Infection;K-18 conjugate;Lung;Lymphocytic Infiltrate;Macrophage;Mediating;microbiota;migration;mouse model;Multiple Organ Failure;Mus;Parasites;Participant;Pathogenesis;recruit;Rodent;SARS-CoV-2 infection;seropositive;Seroprevalences;Severe Acute Respiratory Syndrome;Severity of illness;study population;survival outcome;T cell response;Transgenic Mice;Vaccinated;Vaccination;Variant;Viral;Viral Load result

PROJECT_TITLE: immune regulation by helminths and the microbiota with SARS-Cov2 infection


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Lung

PI_NAMEs: HICKMAN, HEATHER  (contact)

PROJECT_TERMS: 2019-nCoV;ACE2;Animal Model;Cells;Coronavirus;Coronavirus Infections;COVID-19;cytokine;Disease;Enterobacteria phage P1 Cre recombinase;Epidemic;Epithelium;Human;human disease;human model;Immune;Infection;Inflammatory;Knock-in Mouse;Knowledge;Lung;lymph nodes;Morbidity - disease rate;mortality;mouse model;Mouse Strains;Mus;pandemic disease;Pathogenesis;Phase;Population;Production;pulmonary function;receptor;SARS-CoV-2 infection;SARS-CoV-2 pathogenesis;Severe Acute Respiratory Syndrome;T cell response;Tissues;Transgenic Mice;Transgenic Organisms;Viral

PROJECT_TITLE: Antiviral T cell Responses During SARS-CoV-2 Infection


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Infectious Diseases

PI_NAMEs: BRENCHLEY, JASON  (contact)

PROJECT_TERMS: 2019-nCoV;Animals;Asian;Benign;Blood Coagulation Disorders;Cardiovascular Diseases;Cessation of life;Circulation;Coronavirus;COVID-19;Dexamethasone;Diabetes Mellitus;Diarrhea;Disease;Disease Progression;Elderly;experimental analysis;Gastrointestinal tract structure;Goals;granulocyte;Human;Immunity;Incidence;Individual;Inflammation;Lead;longitudinal analysis;Lymphocyte;Macaca;microbial;microbial products;microbiome composition;neutrophil;nonhuman primate;Obesity;Risk Factors;SARS-CoV-2 infection;SARS-CoV-2 pathogenesis;seasonal coronavirus;severe COVID-19;stool sample;Testing;viral RNA;Work

PROJECT_TITLE: Pathogenesis of SARSCov2 infection


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Nutrition;Obesity;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Vaccine Related

PI_NAMEs: BOSIO, CATHARINE  (contact)

PROJECT_TERMS: 2019-nCoV;adaptive immune response;adaptive immunity;Age;animal imaging;Animals;Cause of Death;Cell Physiology;cell type;Cells;Cessation of life;Child;Communicable Diseases;comorbidity;Data;Development;diet-induced obesity;Disease;Disease Progression;early phase clinical trial;Elements;Environment;experience;Flow Cytometry;Generations;Genomics;Goals;Human;Imaging technology;Immune;Immune response;Immunity;In Vitro;in vivo;Infection;Inflammation;Inflammatory Response;Innate Immune Response;insight;lipid mediator;lipidomics;Lipids;Location;Long COVID;Lower Respiratory Tract Infection;Lung;Lung infections;lung pathogen;Mediator;Metabolic;Metabolic Pathway;Metabolism;metabolomics;model development;Modeling;mouse model;multiple omics;Mus;Natural Immunity;new therapeutic target;novel therapeutics;novel vaccines;Obesity;Organ;pandemic disease;pathogen;Pathogenesis;Pathway interactions;Peripheral;Persons;Pharmaceutical Preparations;Phenotype;Population;post SARS-CoV-2 infection;prevent;Primary Infection;Production;pulmonary function;Resolution;Role;Sampling;SARS-CoV-2 immunity;SARS-CoV-2 infection;secondary infection;Symptoms;T-Lymphocyte;Techniques;Telemetry;temporal measurement;Therapeutic;Therapeutic Intervention;Tissues;Vaccination;Vaccines;Virion;Virus

PROJECT_TITLE: Effect of SARS-CoV-2 on host metabolism and its influence on innate and adaptive immunity


NIH_SPENDING_CATS: Anthrax;Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Rare Diseases

PI_NAMEs: LEPPLA, STEPHEN  (contact)

PROJECT_TERMS: 2019-nCoV;Alkaline Phosphatase;Antibodies;Antibody Therapy;Area;Bacillus anthracis;Binding;Biological Assay;Biotinylation;C-terminal;Chimeric Proteins;Chinese Hamster Ovary Cell;commercialization;coronavirus pandemic;cost;COVID-19;COVID-19 detection;cross reactivity;Detection;detection method;diagnostic assay;diagnostic development;diagnostic platform;Diagnostic Procedure;Diagnostic Reagent Kits;dimer;DNA;DNA biosynthesis;DNA Probes;Dot Immunoblotting;Embryo;Enzyme-Linked Immunosorbent Assay;Enzymes;Equipment;Fab Immunoglobulins;Foundations;Genetic;Genetic Transcription;Human Papillomavirus;Hybrids;Immunoglobulin G;improved;In Vitro;innovation;interest;Lateral;Licensing;Messenger RNA;Methods;microbial;milligram;Modification;Monoclonal Antibodies;monomer;Mus;nanoGold;Nucleic Acids;pathogen;Pathogenesis;Pathologic;Peptidyltransferase;point-of-care diagnostics;polyclonal antibody;Preparation;Production;Protein phosphatase;Proteins;Reagent;Recombinant Proteins;Recombinants;Reporter;Research;Research Personnel;Resource-limited setting;Resources;RNA;SARS coronavirus;Single-Stranded DNA;sortase;Specificity;Structure;success;Surface;Suspension Culture;Swab;synthetic construct;System;Testing;Therapeutic Agents;tool;Toxoplasma gondii;Translating;United States National Institutes of Health;Vagina;Variant;viral detection;viral RNA;Work

PROJECT_TITLE: SARS CoV2 Studies in the Microbial Pathogenesis Section/LPD


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

PROJECT_TERMS: 2019-nCoV;Acute;Antibodies;betacoronavirus;Biology;combat;Coronavirus;COVID-19;COVID-19 prevention;Disease;follow-up;global health;Goals;human monoclonal antibodies;Immune response;improved;Individual;interest;neutralizing antibody;next generation;novel;novel coronavirus;Peptides;Plasma;Resolution;SARS-CoV-2 antibody;SARS-CoV-2 spike protein;SARS-CoV-2 variant;stem;Technology;Testing;tool;Vaccine Design;variants of concern;Virus;Work

PROJECT_TITLE: Human monoclonal antibodies against SARS-CoV-2


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

PI_NAMEs: MUNSTER, VINCENT  (contact)

PROJECT_TERMS: 2019-nCoV;ACE2;Address;Aerosols;Animal Model;AstraZeneca COVID-19 vaccine;Birds;China;Chiroptera;COVID-19;cross-species transmission;Decontamination;design;Disease;disease transmission;Ecology;efficacy study;emerging virus;Evolution;Goals;Hamsters;Human;Immunocompromised Host;in vivo Model;Infection;Intranasal Administration;Link;Modeling;Monoclonal Antibodies;nonhuman primate;pandemic disease;Pathogenesis;pre-clinical;preclinical efficacy;programs;public health emergency;receptor;Reporting;Research;response;Rodent;SARS-CoV-2 B.1.351;SARS-CoV-2 transmission;Severity of illness;Surface;transmission process;Vaccination;vaccine efficacy;vaccine platform;Vaccines;Variant;variants of concern;Virus;Work;Zoonoses

PROJECT_TITLE: Virus Ecology Unit - COVID-19 response


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Influenza;Lung;Pneumonia;Pneumonia and Influenza;Prevention;Rare Diseases

PI_NAMEs: BEST, SONJA  (contact)

PROJECT_TERMS: Acute;adaptive immune response;Alveolar;Animals;Anti-Inflammatory Agents;Anti-viral Agents;Avian Influenza;Body Weight decreased;Brain;Bypass;Cause of Death;CCL2 gene;CD8-Positive T-Lymphocytes;Cells;Cessation of life;Clinical;clinical effect;Colchicine;Combined Modality Therapy;Complement;COVID-19;COVID-19 pandemic;COVID-19 treatment;COVID-19/ARDS;cytokine;Cytotoxic T-Lymphocytes;Data;Disease;disease phenotype;Dose;drug action;drug testing;Early treatment;Epithelial Cells;Epithelium;Equilibrium;Failure;follow-up;Genetic Variation;Goals;Hospitalization;Host Defense Mechanism;House mice;Human;human disease;Image;Immune;Immune mediated destruction;Immune response;Immunity;immunopathology;Immunotherapy;Impairment;improved;Inbred BALB C Mice;Infection;Infiltration;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;Influenza;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H5N1 Subtype;influenza infection;Innate Immune Response;inorganic phosphate;Inosine;Interferons;Interleukin-6;Intervention;Laboratories;Literature;Lung;Lung infections;lung injury;lung lobe;lung repair;Mediating;Methods;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mouse Strains;Mus;Myeloid Cells;Nasopharynx;Natural Immunity;Neutrophil Infiltration;novel strategies;Organ;Oseltamivir;Outcome;Pathologic;Pathology;Patients;Phase;pneumocyte;preservation;prevent;Process;Production;Proliferating;Publishing;pulmonary function;Recommendation;Recovery of Function;repaired;Residual state;Resistance;response;Risk;Role;SARS-CoV-2 infection;severe COVID-19;Sex Bias;Sex Differences;Signal Transduction;Stains;Structure;Structure of parenchyma of lung;success;surfactant;T-Cell Depletion;T-Lymphocyte;Testing;therapeutic development;Thrombus;Tissues;transcriptome sequencing;transcriptomics;transmission process;Update;Vaccination;Viral;Viral Pneumonia;Virus;Virus Replication;Work;Zileuton

PROJECT_TITLE: Mechanisms of immunopathology of COVID-19/ARDS, and strategies to mitigate detrimental inflammatory responses


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases

PI_NAMEs: MAYER-BARBER, KATRIN  (contact)

PROJECT_TERMS: 2019-nCoV;Acute Respiratory Distress Syndrome;adaptive immune response;adaptive immunity;Animal Model;Animals;antiviral immunity;biosafety level 3 facility;Cause of Death;Cessation of life;co-infection;Complex;Containment;cytokine;cytokine release syndrome;Environment;Etiology;Functional disorder;Immune response;in vivo;Inflammatory;Inflammatory Response;innate immune mechanisms;Innate Immune Response;insight;Interleukin-1;Interleukin-6;Investigation;Lung;Lung infections;lung pathogen;Molecular;Mus;Mycobacterium tuberculosis;novel therapeutic intervention;operation;pathogen;Pathogenesis;Patients;Pneumonia;programs;Research;response;SARS coronavirus;SARS-CoV-2 infection;severe COVID-19;Tissues;Viral;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Interrogating inflammatory responses to SARS-CoV-2 infection in vivo


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biomedical Imaging;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Infectious Diseases;Lung;Pediatric;Prevention

PI_NAMEs: BARBER, DANIEL  (contact)

PROJECT_TERMS: 2019-nCoV;ACE2;Acute Respiratory Distress Syndrome;Anti-Inflammatory Agents;Anti-viral Response;aspirate;BCG Live;CD8-Positive T-Lymphocytes;cellular imaging;Child;Clinical;Clonal Expansion;confocal imaging;Coronavirus;Coronavirus Infections;COVID-19;COVID-19 severity;CXCL10 gene;cytokine;Development;Disease;Disease Outcome;Disease Progression;Encephalitis;Experimental Models;experimental study;Flow Cytometry;fluorodeoxyglucose;Goals;Host resistance;Human;IFNGR1 gene;Immune;Immune response;Immune system;Immunocompromised Host;immunoregulation;In Vitro;Individual;Infection;Infection Control;Inflammatory Response;interest;Interferon Type II;Interferons;Interleukin-10;Interleukin-6;Intravenous;lung development;Lung Diseases;lung lesion;Macaca;Macaca mulatta;Measurement;Mediating;Modeling;mortality;mouse model;Multisystem Inflammatory Syndrome in Children;Mus;nonhuman primate;Nose;Outcome;Pathology;PET/CT scan;Plasma;post SARS-CoV-2 infection;predictive marker;prevent;prototype;Pulmonary Inflammation;Pulmonary Pathology;receptor;recruit;Regulation;Reporting;Resolution;Role;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;severe COVID-19;Signal Transduction;Structure of mucous membrane of nose;T-Lymphocyte Subsets;tissue resident memory T cell;TNF gene;Transgenic Mice;Tuberculosis Vaccines;Viral;Viral Load result;Virus;X-Ray Computed Tomography

PROJECT_TITLE: SARS-CoV-2 infection of non-human primates


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Pediatric;Prevention;Vaccine Related

PI_NAMEs: BUCHHOLZ, URSULA  (contact)

PROJECT_TERMS: 2019-nCoV;5 year old;ACE2;Adult;airway epithelium;Animals;Antibodies;Antibody Response;Attenuated;Attenuated Vaccines;attenuation;Avulavirus;Cattle;CD8-Positive T-Lymphocytes;Cell Culture Techniques;Cells;Child;Childhood;Clinical Research;Clinical Trials;Collaborations;community transmission;Complement;Complementary DNA;COVID-19;COVID-19 burden;COVID-19 vaccine;Data Analyses;design;dimer;Disease;Dose;Epithelial Cells;Evaluation;Family;Generations;Genes;Hamsters;Homologous Gene;Human;Human Parainfluenza Virus 2;Immune response;Immunity;Immunization;Immunize;immunogenic;immunogenicity;Immunoglobulin A;Immunoglobulin G;improved;In Vitro;Infant;Infection;Injectable;insight;interest;lead candidate;Macaca;Macaca mulatta;manufacture;Manuscripts;Memory;Modeling;Morbidity - disease rate;Mucosal Immune Responses;Mucosal Immunity;mucosal vaccine;Mucous Membrane;murine antibody;Murine pneumonia virus;Mus;neutralizing antibody;next generation;nonhuman primate;Para-Influenza Virus Type 3;parainfluenza virus;Paramyxovirus;pathogen;Phase;phase 1 study;Pneumovirus;Population;preclinical development;preclinical study;prevent;Primates;programs;protective efficacy;Proteins;receptor binding;Recovery;research clinical testing;respiratory;Respiratory syncytial virus;Respiratory System;respiratory virus;reverse genetics;Route;Safety;Sampling;SARS-CoV-2 antibody;SARS-CoV-2 antigen;SARS-CoV-2 immunity;SARS-CoV-2 infection;SARS-CoV-2 spike protein;SARS-CoV-2 transmission;Serum;severe COVID-19;symptomatic COVID-19;System;T-Lymphocyte;Tissues;translational goal;transmission process;Tropism;Upper respiratory tract;vaccine candidate;Vaccine Design;vaccine development;vaccine response;vaccine trial;Vaccines;Variant;variants of concern;vector;vector vaccine;vector-based vaccine;Viral Vector;Virion;Virus Replication

PROJECT_TITLE: Paramyxoviruses as Vaccine Vectors Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Primary Immunodeficiencies;Rare Diseases;Vaccine Related

PI_NAMEs: MURPHY, PHILIP  (contact)

PROJECT_TERMS: 2019-nCoV;3p21;African;Alleles;Animals;Antibodies;Antibody titer measurement;Antigen Receptors;Appearance;arteriole;beta Chain Antigen T Cell Receptor;beta-Chemokines;Binding;bioinformatics tool;Blood;Blood Chemical Analysis;Body Weight decreased;Carbon Dioxide;Cerebellum;Cervical;chemokine;chemokine receptor;Clinical;Clinical Data;cohort;Collaborations;congenital immunodeficiency;COVID-19;COVID-19 mortality;COVID-19 patient;CXC Chemokines;cytokine;Data;Disease;Disease Progression;Dislocations;Dose;drug development;Drug Targeting;Elderly;Endothelial Cells;Endothelium;Epithelial Cells;Epitopes;Erythrocytes;Euthanasia;experience;experimental study;Extravasation;Feces;Female;Genes;Genetic;genome wide association study;Goals;High-Throughput Nucleotide Sequencing;Histopathology;Human;Immune;Immune response;immunodeficiency;immunopathology;immunoregulation;impaired capacity;in vivo;Individual;Infection;infectious disease model;Inflammatory;insight;Interferons;Knock-out;Lethal Dose 50;Leukocyte Trafficking;Leukocytes;Lung;male;Modeling;mortality;Motivation;mouse model;Mus;National Institute of Child Health and Human Development;new therapeutic target;older patient;Pathogenesis;Patients;Pharmaceutical Preparations;Pharyngeal structure;Play;Population;post SARS-CoV-2 infection;Production;Productivity;protective effect;Proteome;Purkinje Cells;receptor;Recovery;Regulation;Reporting;response;RNA vaccination;RNA vaccine;Role;SARS coronavirus;SARS-CoV-2 immune response;SARS-CoV-2 infection;SARS-CoV-2 pathogenesis;screening;seroconversion;Serum;severe COVID-19;Sex Differences;Shapes;Site;small molecule;Swab;System;T cell response;T-Lymphocyte;Techniques;Testing;Transgenic Mice;translational potential;Veins;Viral;Viral Pathogenesis;Virus;Work

PROJECT_TITLE: Immunopathogenesis of SARS-CoV-2 infection


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Hematology;Immunization;Infectious Diseases;Prevention;Vaccine Related

PI_NAMEs: SERETI, IRINI  (contact)

PROJECT_TERMS: 2019-nCoV;Acute;Affect;Antibody Response;Biological Markers;Blood Coagulation Disorders;Clinical;Coagulation Process;Complement Activation;COVID-19;COVID-19 pathogenesis;COVID-19 patient;COVID-19 vaccine;Disease;Endothelium;Enrollment;Evaluation;Functional disorder;Immunity;Immunocompromised Host;Immunologics;Inflammasome;Inflammation;Inflammatory;insight;interest;Intervention;Lymphopenia;mortality;nasal swab;novel coronavirus;pandemic disease;Pathogenesis;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Plasma;Protocols documentation;respiratory;Role;sample collection;Sampling;Serum;Syndrome;T-Lymphocyte;Vaccination;Variant

PROJECT_TITLE: Role of lymphopenia and inflammation in COVID-19 pathogenesis


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Vaccine Related

PI_NAMEs: LISCO, ANDREA  (contact)

PROJECT_TERMS: 2019-nCoV;Clinical;clinical predictors;Collaborations;COVID-19;COVID-19 severity;COVID-19 vaccine;Disease;Goals;human pathogen;Immune response;Immunization;Immunocompetent;Immunocompromised Host;Immunologics;Individual;Longevity;Medical center;Messenger RNA;National Institute of Allergy and Infectious Disease;novel;Outcome;Research Personnel;response;SARS-CoV-2 infection;T cell response

PROJECT_TITLE: Identification of immunological predictors of COVID-19 clinical outcomes


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Primary Immunodeficiencies;Rare Diseases;Sexually Transmitted Infections

PROJECT_TERMS: Ablation;acquired immunodeficiency;Antigen-Presenting Cells;antiretroviral therapy;Anus;Blood Cells;Bone Marrow Transplantation;Cells;Characteristics;Chemicals;Clinic;Clinical;clinical care;clinical center;clinical efficacy;cohort;congenital immunodeficiency;cytotoxic;Development;Diagnosis;Disease;Disease Progression;Dysplasia;Epidemiology;Epithelium;exome sequencing;Gene Expression Profiling;genome sequencing;Goals;HIV;HIV/AIDS;Human;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;IL7 gene;Image;Immune;immune reconstitution;Immune Targeting;Immunity;Immunization;Immunocompetent;Immunocompromised Host;immunodeficiency;Immunologics;Individual;Intervention;Langerhans cell;Lesion;Lymphoid;Lymphopenia;Malignant Neoplasms;Mediating;men who have sex with men;microbiome analysis;Modeling;Molecular;Molecular Epidemiology;Morbidity - disease rate;Mucous Membrane;Natural History;Natural Killer Cells;next generation;novel;Operative Surgical Procedures;Patients;Persons;Predisposition;Prevention strategy;Proteins;Recombinants;recruit;Recurrence;Reporting;Role;Site;Skin;T cell response;T-Lymphocyte;tool;trafficking;transgender;treatment strategy;United States National Institutes of Health;Viral;Viral Epidemiology;Virion;whole genome;Woman;Work

PROJECT_TITLE: Immunopathogenesis of skin and mucosal Human Papillomavirus (HPV)-related diseases


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Cardiovascular;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Hematology;Immunization;Infectious Diseases;Prevention;Vaccine Related

PI_NAMEs: LUSSO, PAOLO  (contact)

PROJECT_TERMS: 2019-nCoV;Adenovirus Vector;Animal Model;Animals;Antibodies;Antigens;Autoantibodies;Autologous;Binding;Blood donor;Blood Vessels;Cardiac Surgery procedures;Characteristics;chemokine;Clinical;Collaborations;Communicable Diseases;Complex;Complication;Core Protein;COVID-19;COVID-19 complications;COVID-19 pathogenesis;COVID-19 patient;COVID-19 vaccine;Cytoplasmic Tail;Data;design;Development;Diffuse;Dose;Enzyme-Linked Immunosorbent Assay;Epitopes;experience;extracellular;Glycoproteins;Harvest;Heparin;heparin-induced thrombocytopenia;HIV-1;HIV-1 vaccine;Hospitalization;Hybrids;Immune response;Immunize;Immunoassay;immunogenic;immunogenicity;Immunology procedure;improved;In Vitro;in vivo;Inbred BALB C Mice;Individual;Lentivirus;Life;Mammalian Cell;Membrane;Messenger RNA;Molecular;Monoclonal Antibodies;mouse model;Multiple Organ Failure;Mus;neutralizing antibody;Normal Range;novel coronavirus;Orthopedic Surgery;Pathogenesis;Pathogenicity;Patients;PF4 Gene;Platelet Activation;Platelet Count measurement;Prevention;Production;Protein Subunits;Proteins;Reporting;Research;Role;SARS-CoV-2 spike protein;Serum;severe COVID-19;Severity of illness;SIV;SIV envelope protein gp41;success;Sucrose;Surface;Syndrome;Tail;Technology;Testing;Therapeutic;Thrombocytopenia;Thrombosis;Time;Ultracentrifugation;Vaccinated;Vaccination;vaccine platform;Vaccines;variants of concern;Virion;Virus;Virus Assembly;Virus-like particle;Western Blotting

PROJECT_TITLE: Pathogenesis studies on COVID-19 and development of a VLP-forming mRNA vaccine against SARS-CoV2


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Lung;Prevention;Vaccine Related

PI_NAMEs: GRIGG, MICHAEL  (contact)

PROJECT_TERMS: 2019-nCoV;ACE2;Address;Amino Acids;Antibody Response;betacoronavirus;Binding;Birds;Camels;Cells;Complex;Conserved Sequence;Coronavirus;COVID-19;cytotoxic;Disease Outbreaks;Dromedaries;Endosomes;Epidemic;Etiology;Evolution;experience;Genetic;Genetic Drift;Genetic Recombination;Genome;genome-wide;Genomic Segment;Genomics;Giardia;Goals;Haploidy;Human;Immune response;immunogenic;Kinetics;Knowledge;Membrane;Methodology;Middle East Respiratory Syndrome Coronavirus;Molecular;mosaic;Mucosal Immunity;Mutation;N-Glycosylation Site;N-terminal;National Institute of Allergy and Infectious Disease;neutralizing antibody;Nucleic Acids;Oral;pandemic disease;Parasites;Parasitology;Parents;Pathogenesis;Poly A;Population;population genetic structure;Positioning Attribute;programs;Protein Region;Proteins;public health emergency;receptor;respiratory;respiratory virus;RNA Viruses;Role;SARS coronavirus;SARS-CoV-2 antigen;SARS-CoV-2 immunity;SARS-CoV-2 spike protein;Saudi Arabia;scaffold;Shapes;Sorting;Structural Models;Surface Antigens;surveillance study;Techniques;ubiquitin ligase;Ubiquitination;vaccine development;Vaccines;Viral;Viral Genome;Virion;Virus;Virus-like particle;Visualization

PROJECT_TITLE: Virus evolution, entry, pathogenesis and vaccine development


PI_NAMEs: FARBER, JOSHUA M (contact)

PROJECT_TERMS: 2019-nCoV;Antibodies;Blood;Cell Line;cell motility;Cells;chemokine;chemokine receptor;Complex;Coupled;COVID-19;cytokine;Data;Dendritic Cells;Disease;experimental study;Extravasation;FDA approved;Flow Cytometry;Genes;Genetic Polymorphism;genome wide association study;Goals;GTP-Binding Proteins;Hospitalization;Host Defense;Human;Immune response;Immune system;Individual;Infection;Inflammation;inflammatory milieu;interest;Leukocyte Trafficking;Leukocytes;Ligands;Lymphocyte;Lymphocyte Subset;lymphocyte trafficking;Mediating;migration;monocyte;Mononuclear;Morbidity - disease rate;Mus;Natural Killer Cells;Pathogenesis;Pathology;Patients;Pattern;Pneumonia;prevent;Production;Proteins;receptor;receptor expression;Role;small molecule;System;T-Lymphocyte;therapeutic target;tissue injury;Tissues;trafficking;Viral

PROJECT_TITLE: Trafficking of Lymphocyte Subsets in Host Defense and Immunopathogenesis in COVID-19


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases

PI_NAMEs: YEWDELL, JONATHAN W (contact)

PROJECT_TERMS: 2019-nCoV;A549;ACE2;Affinity;Alanine;Antibody Specificity;antigen processing;Binding;Biological;Biological Assay;Cells;Cellular biology;chemokine;Coronavirus;Coronavirus Infections;cytokine;Epitopes;Goals;Histocompatibility Antigens Class I;Human;Interferometry;Libraries;MHC Class I Genes;Monoclonal Antibodies;Mus;Nucleocapsid Proteins;Pathway interactions;Peptide Hydrolases;peptide I;Process;Proteins;Proteome;receptor;Recombinants;Reporter;SARS-CoV-2 immunity;SARS-CoV-2 spike protein;seasonal coronavirus;Sleeping Beauty;Stomatitis;System;TMPRSS2 gene;Transfection;translatome;Transposase;vector;Vesicular stomatitis Indiana virus;Viral Physiology;Virus;Virus Receptors

PROJECT_TITLE: SARS-CoV2 Immunity and Cell Biology


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Lymphatic Research;Orphan Drug;Rare Diseases;Vector-Borne Diseases;Zika Virus

PI_NAMEs: GHEDIN, ELODIE  (contact)

PROJECT_TERMS: Acetylcholine;Address;Adopted;Adult;Affect;analog;Animal Model;Animals;Antibiotics;Arbovirus Infections;Arboviruses;Arthropods;Autophagocytosis;Bacteria;Bacterial Proteins;Biological Assay;Biological Availability;Biology;Brugia;Brugia malayi;Cell Physiology;Cells;Characteristics;Collaborations;Cues;Culicidae;design;Development;Drug Combinations;Drug Interactions;drug repurposing;Drug Targeting;Elements;Elephantiasis;endosymbiont;Enzymes;Ethanolamines;Evaluation;experimental study;Family;FDA approved;Female;Filarial Elephantiases;fitness;Fluorescence Microscopy;G-Protein-Coupled Receptors;Genes;Gerbils;Germany;Goals;Health;Human;Immune;Immune system;immunoregulation;in silico;In Vitro;in vitro Model;in vitro testing;in vivo;in vivo Model;Infection;Insecta;insight;Laboratories;Life Cycle Stages;Litomosoides;Lymphatic;Lymphatic Endothelial Cells;male;Manuscripts;Mediating;Messenger RNA;Metabolic;metabolomics;MicroRNAs;Modeling;Molecular;Morbidity - disease rate;Motility;neglected tropical diseases;Nematoda;novel;novel strategies;novel therapeutic intervention;Onchocerciasis;Organism;Outcome;Parasite Control;Parasites;Parasitic infection;Parasitic nematode;parasitism;pathogen;Pathology;Pathway interactions;Pharmaceutical Preparations;Pharmacotherapy;Phase;Population;protein expression;Proteins;Proteomics;Pyruvate Kinase;reconstruction;Research;Role;rottlerin;symbiont;Symbiosis;Systems Biology;Technology;Testing;Therapeutic;Time;transcriptomics;transmission process;Vaccines;Variant;vector;Virus Diseases;Wolbachia;Work;Zika Virus;ZIKV infection

PROJECT_TITLE: Host-pathogen interactions in filarial worm infections


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Childhood Obesity;Chronic Obstructive Pulmonary Disease;Clinical Research;Data Science;Emerging Infectious Diseases;Genetics;Human Genome;Immunization;Infectious Diseases;Influenza;Lung;Machine Learning and Artificial Intelligence;Microbiome;Nanotechnology;Obesity;Pediatric;Pneumonia and Influenza;Precision Medicine;Prevention;Tobacco;Tobacco Smoke and Health;Vaccine Related

PROJECT_TERMS: Affect;Age;American;Anatomy;Behavior;Biodiversity;Biological;Biological Assay;biomarker identification;Bronchoscopy;Carbon Nanotubes;Cells;Chronic Obstructive Pulmonary Disease;Classification;Clinical;Collaborations;Communicable Diseases;comorbidity;Complex;Computer Vision Systems;Critical Care;Data;deep learning;design;Detection;Development;diagnostic platform;Disease;Disease Progression;Disease susceptibility;dysbiosis;Effectiveness;Environment;Evolution;exposure to cigarette smoke;Ferrets;flu transmission;follow-up;Frequencies;Gambia;Gene Expression;Gene Expression Profile;generative adversarial network;Genes;Genetic Variation;genomic profiling;Goals;Health;Immune;Immune response;improved;Individual;individual response;Infection;infection risk;Inflammatory;inflammatory marker;Influenza;Influenza A virus;influenza infection;Influenza vaccination;influenza virus vaccine;influenzavirus;innovation;Integration Host Factors;Intervention;Journals;Lung Diseases;Machine Learning;machine learning model;Manuscripts;Medicine;metabolomics;Metagenomics;Methods;microbial colonization;microbial community;microbiome;microbiome analysis;Microfluidics;Modeling;Molecular;Mothers;mouse model;multiscale data;Mutation;Neonatal;neonatal infection;neonate;Newborn Infant;Non obese;novel;novel diagnostics;novel therapeutics;obese person;Obesity;Optics;oral commensal;Oropharyngeal;pathogen;Pathogenesis;Pattern;Physiological;Population;pre-clinical;predictive marker;Preparation;pressure;Process;programs;Proteins;Proteomics;Publishing;Raman Spectrum Analysis;rapid detection;rapid test;Recurrence;Reporting;Research Design;respiratory;respiratory microbiome;respiratory pathogen;Respiratory System;Respiratory Tract Infections;response;response biomarker;Risk;Risk Factors;RNA;Running;Sample Size;Sampling;seasonal influenza;Severities;Severity of illness;simulation;Smoker;Source;Staphylococcus aureus;System;Systems Biology;Taxonomy;Techniques;Testing;Time;Tissues;Training;trait;Transcript;transcriptomic profiling;transcriptomics;transmission process;Vaccinated;Vaccination;Vaccine Design;vaccine effectiveness;vaccine immunogenicity;vaccine response;vaccine strategy;vaccine trial;Vaccinee;Vaccines;Variant;Viral;viral detection;viral transmission;Virion;virology;Virus;virus classification;virus identification;Weight;Whole Blood;Whole Organism;Work

PROJECT_TITLE: Genomic profiling of influenza infections to identify biomarkers of disease severity


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Microbiome

PROJECT_TERMS: 2019-nCoV;ACE2;adaptive immunity;Animal Model;Animals;Anti-viral Agents;Autopsy;B-Lymphocytes;Base Sequence;Binding;Biological Assay;Bronchoscopy;Caribbean region;Clinical;clinical diagnostics;cohort;Collaborations;Communication;Communities;Consensus;Country;COVID-19;COVID-19 diagnosis;COVID-19 patient;Critical Illness;Cross-Sectional Studies;Data;Data Set;Death Rate;deep sequencing;Defect;Defense Mechanisms;Disease;Dominican Republic;epidemiology study;Europe;Evaluation;Event;Evolution;follow-up;Follow-Up Studies;genetic analysis;Genetic Variation;genome sequencing;genomic epidemiology;Genomics;Genotype;Goals;Haiti;Haplotypes;Hereditary Disease;Hospitals;Human;Immune response;Immunocompromised Host;In Vitro;Individual;Infection;Integration Host Factors;Intubation;Island;Libraries;Logistic Regressions;longitudinal analysis;Manuscripts;Measures;Mechanical ventilation;Mesocricetus auratus;Metadata;Metagenomics;metatranscriptomics;Methodist Church;Methods;microbial community;Minority;Modeling;Molecular Epidemiology;Morphologic artifacts;Mutation;nasopharyngeal swab;National Institute of Allergy and Infectious Disease;Nature;nirmatrelvir;North America;novel;Nucleotides;Obesity;Outcome;pandemic disease;Pathogenesis;Patients;Peptide Hydrolases;Persons;Phylogenetic Analysis;Population;Populations at Risk;Preparation;pressure;Proteins;Public Health;Publications;Publishing;random forest;Readiness;receptor;receptor binding;Recording of previous events;Regimen;remdesivir;Research Design;Resistance;respiratory;respiratory microbiome;Respiratory System;Ritonavir;RNA-Directed RNA Polymerase;Role;Route;Sampling;SARS-CoV-2 genome;SARS-CoV-2 infection;SARS-CoV-2 positive;Sequence Analysis;severe COVID-19;Severity of illness;Specimen;Surveillance Program;Symptoms;System;Testing;Therapeutic;Tissues;Training;transmission process;Travel;Variant;Viral;viral genomics;Viral Load result;Virus;Virus Replication;Visit;West Indies;whole genome

PROJECT_TITLE: Determining factors of transmission and evolution of SARS-CoV-2 in populations at risk


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

PI_NAMEs: MOIR, SUSAN  (contact)

PROJECT_TERMS: 2019-nCoV;acute infection;Address;Adenoidal structure;Affect;Antibodies;Antibody Response;Antibody Therapy;Antibody titer measurement;Antigens;Attenuated;Autoimmune Diseases;B-Lymphocyte Subsets;B-Lymphocytes;Binding;Biological Assay;Blood;Blood specimen;booster vaccine;breakthrough infection;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Child;Chronic;Circulation;cohort;Collaborations;COVID-19;COVID-19 vaccination;COVID-19 vaccine;design;Development;Disease;Disease Progression;Dose;Eligibility Determination;emerging pathogen;Enrollment;Evaluation;Extramural Activities;Flow Cytometry;Frequencies;Generations;Goals;Health;Hepatitis C;high dimensionality;HIV;HIV Infections;HIV vaccine;Hospitalization;Human;Humoral Immunities;Immune;Immune response;Immunologics;Immunology;Immunophenotyping;imprint;Individual;Infection;Inferior;Knowledge;Longitudinal Studies;Lymphoid Tissue;Manuscripts;Measures;Messenger RNA;National Institute of Allergy and Infectious Disease;neutralizing antibody;Outcome;Participant;participant enrollment;Patients;Persons;Pharyngeal structure;Phenotype;Preparation;prevent;Protein Binding Domain;Protocols documentation;Publishing;receptor binding;Research Personnel;response;RNA vaccine;Role;Sampling;SARS-CoV-2 exposure;SARS-CoV-2 immunity;SARS-CoV-2 infection;SARS-CoV-2 spike protein;Specimen;Survivors;symptomatic COVID-19;T cell response;Therapeutic Intervention;Time;Tissues;Tonsil;Universities;Vaccination;vaccine immunogenicity;vaccine response;vaccine trial;Vaccines;Variant;Virus;Visit;Writing

PROJECT_TITLE: Immunologic Studies Associated with COVID-19


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Prevention

PI_NAMEs: PREVOTS, D. REBECCA  (contact)

PROJECT_TERMS: 2019-nCoV;Address;Adoption;Age;Americas;Antibodies;Antibody Response;Behavioral;Binomial Model;Blood specimen;Cervical;Clinical;cohort;Collaborations;Communities;Complex;Costa Rica;Costa Rican;COVID-19;COVID-19 pandemic;COVID-19 patient;Crowding;Diagnosis;Disease;Enrollment;follow-up;Goals;Healthcare Systems;Heterogeneity;Household;Human Papilloma Virus Vaccine;Immune response;Immunoglobulin G;Immunology;indexing;Individual;Infection;infection rate;infection risk;Infrastructure;Interview;Malignant Neoplasms;Masks;Medical;Methods;National Cancer Institute;Nucleocapsid;Patient Self-Report;Prevention Measures;primary endpoint;Prospective Studies;Prospective, cohort study;protective efficacy;randomized trial;Recording of previous events;Research;Research Institute;Risk;Risk Factors;SARS-CoV-2 antibody;SARS-CoV-2 infection;SARS-CoV-2 positive;SARS-CoV-2 transmission;secondary infection;Serology;Serum;sex;Signs and Symptoms;Socioeconomic Status;Source;Testing;transmission process;Vaccines;Viral

PROJECT_TITLE: Household transmission of COVID19 in Costa Rica


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention;Vaccine Related

PI_NAMEs: CONNORS, MARK  (contact)

PROJECT_TERMS: 2019-nCoV;acute infection;Adenoviruses;Agonist;Animal Experiments;Animal Model;Animals;Antibodies;Antibody Response;Antibody titer measurement;Antigens;Area;Attenuated;Authorization documentation;B-Lymphocytes;Body Weight decreased;Complement;COVID-19 survivors;COVID-19 vaccine;cytokine;Disease;Dose;Frequencies;Gastrointestinal tract structure;gene product;Goals;HIV;Household;Human;Human poliovirus;Immune response;Immunity;Immunization;Immunize;immunogenic;immunogenicity;Immunology;Infection;Inflammatory;Influenza;influenzavirus;Interruption;Intramuscular;Laboratories;Licensing;Measurement;Measures;Membrane Glycoproteins;Mesocricetus auratus;Messenger RNA;Modeling;Molecular Conformation;Mucosal Immune Responses;Mucosal Immunity;Mucous Membrane;Mus;Natural History;Nature;neutralizing antibody;Oryctolagus cuniculus;Participant;Particulate;Pathology;Peripheral Blood Mononuclear Cell;Play;recombinant adenovirus;Recombinants;Respiratory Syncytial Virus Infections;response;Role;Sampling;SARS-CoV-2 B.1.617.2;SARS-CoV-2 immunity;SARS-CoV-2 infection;SARS-CoV-2 spike protein;SARS-CoV-2 transmission;Science;Serum;Severity of illness;Stimulus;success;T-Lymphocyte;Testing;Time;transmission process;Upper respiratory tract;Vaccination;vaccine platform;Vaccinee;Vaccines;vector;Vietnam;Viral;Viral Vaccines;Viral Vector;Virus;Virus Replication;Virus-like particle;Work

PROJECT_TITLE: Immunity to SARS-CoV-2 After Natural Infection or Vaccination


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Vector-Borne Diseases

PI_NAMEs: LEHMANN, TOVI  (contact)

PROJECT_TERMS: 2019-nCoV;3 year old;Affect;Africa;Africa South of the Sahara;African;Age;Americas;Antibodies;antibody detection;Antibody titer measurement;Antigens;Area;Asia;Biological Assay;Blood;Blood specimen;Burkina Faso;Cities;Collaborations;Country;COVID-19;COVID-19 monitoring;Culicidae;Data;density;Disease Surveillance;Environment;Enzyme-Linked Immunosorbent Assay;Epidemiology;epidemiology study;Europe;experimental study;feeding;Female;frontier;Home;Hour;Human;Human Bites;human disease;human subject;Immunoassay;Immunoglobulin G;Individual;Infection;Laboratories;Mali;Measures;Methods;Monitor;novel;Nucleocapsid;pandemic disease;Paper;Population;pre-pandemic;Process;Protocols documentation;Publishing;receptor binding;Rest;Route;Rural;Rural Community;rural setting;Sampling;SARS-CoV-2 infection;SARS-CoV-2 transmission;Serology;seropositive;Seroprevalences;serosurveillance;Shapes;Site;spatiotemporal;Specificity;Specimen;System;Techniques;Time;Training;Transportation;United States National Institutes of Health;vector-borne;Visit;Widespread Disease;Withdrawal;Work;Writing

PROJECT_TITLE: Evaluating the determinants of the spread of COVID-19 between and within rural communities in Mali, West Africa based on blood-fed mosquitoes


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Coronaviruses;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

PI_NAMEs: KELSALL, BRIAN  (contact)

PROJECT_TERMS: 2019-nCoV;Address;Alcohol consumption;Anatomy;Autopsy;Biological Markers;Blood;brain fog;Case/Control Studies;Cells;chemokine;Collaborations;Colon;COVID-19 patient;Development;dysbiosis;enteric infection;Epithelial Cells;Fatigue;Functional disorder;Genes;Goals;Hospitals;Human;Immunofluorescence Immunologic;In Situ Hybridization;in vivo;Individual;Infection;intestinal barrier;intestinal epithelium;Intestinal permeability;Intestines;Laboratories;Long COVID;Macrophage;Manuscripts;Medical center;Messenger RNA;microbial;mouse model;Mus;National Institute of Allergy and Infectious Disease;Nuclear Proteins;Obesity;Patients;Physiological;Preparation;receptor;Research Personnel;Role;Route;Sampling;SARS-CoV-2 antibody;SARS-CoV-2 infection;SARS-CoV-2 spike protein;Stains;Symptoms;systemic inflammatory response;Technology;Thinking;Time;Tissues;Viral;Viral Load result;viral RNA;Virus

PROJECT_TITLE: SARS-CoV2 infection in the intestine


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

PI_NAMEs: LONG, CARRIE MAE  (contact)

PROJECT_TERMS: Aerosols;Animal Model;Bacteria;Bacteriology;Biological;bioweapon;Cavia;Collaborations;Communicable Diseases;Coxiella burnetii;Dairying;Delayed Hypersensitivity;Development;Disease;Disease Outbreaks;DNA Sequence Alteration;Economics;flu;Gene Modified;Genes;genetic manipulation;Genome;genome sequencing;Goat;guinea pig model;Health;Human;Human Characteristics;human disease;human model;Hypersensitivity;Immune;Immune response;Immunity;Immunobiology;Immunologics;improved;in vivo;Induced Mutation;Infection;Integration Host Factors;interest;Length;Licensing;Lipopolysaccharides;Mediating;Modeling;mouse model;Mutation;National Institute of Allergy and Infectious Disease;Netherlands;novel;Organism;Oxidative Stress;pathogen;Phase;programs;Proteins;Public Health;Q Fever;Reaction;Reagent;Research;response;RNA;Ruminants;Severities;sex;single cell sequencing;Structure;System;Techniques;Testing;Therapeutic;therapeutic target;Tissues;transmission process;Type IV Secretion System Pathway;United States;United States National Institutes of Health;Vaccination;vaccine candidate;vaccine evaluation;vaccine platform;Vaccines;Virulence;Virulence Factors;whole genome;Work;Zoonoses

PROJECT_TITLE: Coxiella burnetii immunobiology, host-pathogen modeling, and countermeasure development


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Racial and Ethnic Minority Health Research

PI_NAMEs: MATZINGER, POLLY C (contact)

PROJECT_TERMS: Age;Age Months;Agriculture;Asthma;Bacille Calmette-Guerin vaccination;Cessation of life;chemical reaction;Child;Complex;Control Groups;Country;COVID-19;COVID-19 mortality;COVID-19 pandemic;COVID-19 sequelae;Crowding;Data;Death Rate;Development;Diabetes Mellitus;Disease;Drops;Epidemiologic Methods;Equation;Ethnic Origin;Frequencies;Frontline worker;Future;future pandemic;Government;Graph;Hispanic;Hospitalization;Immigrant;Incidence;Individual;Infection;infection rate;Intervention;Kinetics;Late Effects;Latino;Latino Population;Masks;mathematical methods;Methods;Modeling;Not Hispanic or Latino;pandemic disease;Persons;Policies;Policy Developments;Population;Predisposition;Race;Reaction;Regression Analysis;Relaxation;Resistance;Restaurants;Risk;Risk Factors;school closure;Schools;Series;Statistical Methods;Time;Visual;Visualization;Vitamin D;Work

PROJECT_TITLE: Analyzing Covid-19


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lyme Disease;Rare Diseases;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases

PI_NAMEs: MARQUES, ADRIANA R (contact)

PROJECT_TERMS: adaptive immune response;Anaplasma phagocytophilum;Anaplasmosis;Animal Model;Animals;anti-tick vaccine;Arthropods;Babesia microti;Babesiosis;Bacteriology;Biological Process;Biopsy;Black-legged Tick;Blood;Blood Platelets;Body Weight;Borrelia burgdorferi;Borrelia mayonii;Borrelia miyamotoi;Case Study;Cavia;Cells;Cessation of life;Clinical;clinical development;Coagulation Process;Diagnosis;differential expression;Disease;Dissociation;Ehrlichia;Ehrlichiosis;experience;Exposure to;feeding;Future;Genes;Histopathology;Human;human disease;Immune response;Immunity;immunoregulation;Individual;Infection;Innate Immune Response;Ixodes;Ixodidae;Laboratories;Life;Lyme Disease;Malaria;Methodology;Molecular;Molecular Biology;molecular vector;Monitor;nano-string;National Institute of Allergy and Infectious Disease;Nature;Oryctolagus cuniculus;Paraffin;Participant;pathogen;Persons;Powassan virus;preservation;Process;Proteins;Proteomics;Protocols documentation;Pruritus;Public Health;Research;Resistance;Resolution;response;RNA;Role;Salivary;Salivary Proteins;single cell analysis;single-cell RNA sequencing;Skin;skin irritation;Standardization;Suspensions;System;Technology;tick bite;tick feeding;tick saliva;Tick-Borne Diseases;Tick-Borne Encephalitis;Ticks;Time;transcriptome sequencing;transcriptomics;transmission process;United States;Vaccine Design;vector;Virus;Xenodiagnosis

PROJECT_TITLE: Investigating the Human Immune Response to Ixodes scapularis Tick Bites


NIH_SPENDING_CATS: Clinical Research;Immunization;Infectious Diseases;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PI_NAMEs: KAMHAWI, SHADEN  (contact)

PROJECT_TERMS: Active Sites;Adenosine;Africa;Animals;Antibodies;antigen test;Antigens;Arthropod Vectors;Attenuated;Attenuated Vaccines;Automobile Driving;Award;Beds;Biological Markers;Bite;Blood;Cellular Immunity;Chronic;Chronic Phase;Clinical;clinical center;Clinical Trials;Collaborations;Communities;Cutaneous Leishmaniasis;Data;Data Collection;Deposition;Development;Disease;Disease Outcome;disease transmission;DNA analysis;Eastern Africa;effectiveness testing;Ethics;Ethiopia;Exposure to;Faculty;Female;Frequencies;Funding;Future;Gene Deletion;gene function;Genetic;Goals;Grant;Guidelines;Health Sciences;Human;Hybrids;Hypersensitivity skin testing;Immune response;Immunity;immunogenic;immunogenicity;Immunoglobulin M;In Vitro;in vivo;India;Individual;Infection;Inflammasome;Inflammatory Response;Innate Immune Response;Insecticides;Institutional Review Boards;interdisciplinary approach;interest;Interferon Type II;International;international center;Interruption;Investigation;Italy;Kenya;Knowledge;Laboratories;Laboratory Finding;Laboratory Research;Leishmania;Leishmania donovani;Leishmaniasis;leishmanin;Mali;Malnutrition;manufacture;Manuscripts;Mediating;Medical center;Medicine;Midgut;Mite Infestations;Mites;Modeling;National Institute of Allergy and Infectious Disease;natural antibodies;Nature;novel;Ohio;Parasites;Partner in relationship;pathogen;Pathogenesis;Pathogenicity;Peer Review;Peripheral Blood Mononuclear Cell;Phlebotominae;Phlebotomus;Post Kala-Azar Dermal Leishmaniasis;Printing;Process;Production;Productivity;programs;Protocols documentation;Publications;Publishing;Recombinants;Research;Resources;Review Committee;Risk Factors;RNA;Rodent Model;Role;Salivary;Salivary Glands;Salivary Proteins;sample collection;Site;Skin;Source;Specimen Handling;Sri Lanka;Sudan;tool;transmission process;Trimethoprim-Sulfamethoxazole;Tunisia;United States National Institutes of Health;Universities;University Health Services;vaccine candidate;Vaccines;Validation;vector;vector competence;vector-borne pathogen;Vector-transmitted infectious disease;Vertebrates;Visceral Leishmaniasis;volunteer;Work

PROJECT_TITLE: Vector-borne pathogen transmission


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;Immunization;Immunotherapy;Infectious Diseases;Orphan Drug;Pediatric;Prevention;Primary Immunodeficiencies;Rare Diseases;Vaccine Related

PI_NAMEs: RICOTTA, EMILY  (contact)

PROJECT_TERMS: 2019-nCoV;ACE2;Anaphylaxis;Antibodies;Attenuated Vaccines;Authorization documentation;B-Cell Antigen Receptor;B-Lymphocytes;Binding;Chickenpox Vaccine;Chronic Granulomatous Disease;chronic infection;cohort;Common Variable Immunodeficiency;Complement;congenital immunodeficiency;COVID-19;COVID-19 prevalence;COVID-19 vaccination;COVID-19 vaccine;Cytokinesis;Data;Defect;Disease;DNA;Dose;Dryness;Emergency Situation;Enrollment;Epstein-Barr Virus Infections;Exclusion;experience;Functional disorder;Funding;GATA2 deficiency;General Population;Genes;Genetic Recombination;Haemophilus influenzae type b;healthy volunteer;Herd Immunity;Hyper-IgE Syndrome;Immune;immune activation;Immune response;Immune System Diseases;immunodeficiency;immunogenicity;Immunoglobulin G;Immunologics;immunomodulatory therapies;Impairment;Individual;Inflammasome;Inflammatory;Influenza;interest;Interferon Type II;Interleukin-12;Laboratories;Leukocyte Adhesion Deficiency;Life;Light;Link;Literature;Magnesium;Measles-Mumps-Rubella Vaccine;Measures;Medicine;Minority Groups;National Institute of Allergy and Infectious Disease;Neonatal Onset Multisystem Inflammatory Disease;Neoplasms;neutrophil;novel;Participant;participant enrollment;Pathway interactions;Peripheral Blood Mononuclear Cell;Persons;Phosphatidylinositols;Phosphotransferases;Plasma;Polyglandular Autoimmune Syndrome Type I;Population;post SARS-CoV-2 infection;Reporting;response;RNA;RNA vaccine;Safety;saliva sample;sample collection;Sampling;SARS-CoV-2 BA.1;SARS-CoV-2 infection;seroconversion;Serum;Severe Combined Immunodeficiency;Severities;Severity of illness;STAT1 gene;Stat3 protein;Symptoms;T cell response;T-Lymphocyte;United States;Update;Vaccination;vaccine immunogenicity;vaccine trial;Vaccines;Variant;Whole Blood;Wiskott-Aldrich Syndrome;X-Linked Agammaglobulinemia

PROJECT_TITLE: Immune response to COVID-19 vaccination in individuals with immune disorders


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Neurosciences;Prevention;Vaccine Related

PI_NAMEs: FRISCHMEYER-GUERRERIO, PAMELA  (contact)

PROJECT_TERMS: Abdominal Pain;Acute;Age;Airway Resistance;Allergic;Allergic Reaction;allergic response;Ambulatory Care Facilities;Anaphylaxis;Anxiety;Blinded;blood pressure elevation;booster vaccine;Chest;Chronic;Classification;Clinical;clinical center;cohort;Complement 5a;Complement Activation;COVID-19;COVID-19 vaccine;detection method;Disease;Distress;Dizziness;Dose;double-blind placebo controlled trial;Event;Excipients;experience;Female;Goals;Heart Rate;high risk;Histamine;Hour;Hydrocortisone;Hypersensitivity skin testing;Hypothalamic structure;IgE;Immunization;Individual;Injections;Intensive Care Units;Leukotriene E4;mast cell;Mediating;Messenger RNA;Meta-Analysis;Metanephrine;Neurologic;Neurologic Symptoms;novel;open label;Organ;Outcome;Outpatients;Paresthesia;Participant;Pathway interactions;Patients;Pfizer-BioNTech COVID-19 vaccine;Pharyngeal structure;Phase;Pituitary Gland;Placebos;Plasma;Polyethylene Glycols;prevent;Process;Public Health;Randomized;Reaction;Recording of previous events;Recurrence;Reporting;Research Personnel;response;Risk;RNA vaccine;Safety;Saline;Screening procedure;Sensory;Serum;severe COVID-19;Severities;Site;Stress;Sympathetic Nervous System;Symptoms;System;trend;Tryptase;United States National Institutes of Health;Urine;Vaccination;Vaccines

PROJECT_TITLE: COVID vaccine-associated allergic reactions


NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

PI_NAMEs: TIRLONI, LUCAS  (contact)

PROJECT_TERMS: Adult women;Amblyomma;Ambylomma americanum;Animal Model;Antibodies;Argasidae;B-Lymphocyte Epitopes;Bacteria;Binding;Biochemical;Biological Assay;Biology;Bite;Black-legged Tick;Blood;Blood coagulation;Borrelia;Borrelia burgdorferi;C3H/HeN Mouse;cadherin 5;Catalogs;Categories;Cattle;cell motility;Chromatography;Coagulation Process;Code;Competitive Binding;Complement;Complement Membrane Attack Complex;complement system;Cyclophilin A;Data Set;Deposition;Development;differential expression;Dimensions;DNA;Dose;Elongation Factor;Embryonic Development;Endothelial Cells;Enzyme-Linked Immunosorbent Assay;Epitope Mapping;Epitopes;Family;feeding;Female;Fibrin;functional group;Gelatinase A;Gene Expression;Gene Expression Profile;Gene Silencing;Generations;Genes;Genetic Transcription;Heart;heme-binding protein;Hemorrhage;Hemostatic function;Histone H3;histopathological examination;Hour;Housekeeping Gene;Immune response;Immune Sera;Immune system;Immunization;Immunoglobulin G;in silico;In Vitro;in vitro Assay;in vivo;Individual;Inflammation;Insecta;insight;internal control;Ixodes persulcatus;Ixodidae;keratinocyte;Larva;Lectin;Link;Location;Lyme Disease;Maps;Mediating;Medical;Metabolic Pathway;Methods;Midgut;migration;Modeling;Molecular Biology;Ornithodoros;Oryctolagus cuniculus;pathogen;Pathway interactions;Pattern;Peptide Hydrolases;Peptides;Permeability;Phase;Physiology;Plasmin;Precipitation;Process;Protease Inhibitor;protein aminoacid sequence;Protein Biosynthesis;protein degradation;protein expression;Proteins;Proteomics;Recombinant Proteins;Recombinants;Research;Rhipicephalus;Ribosomal Proteins;Role;Saliva;saliva proteome;Salivary;Salivary Glands;Salivary Proteins;screening;Serine Protease;Serpins;Site;Skin;Structure;System;Techniques;Testing;Thrombin;Tick Control;tick feeding;tick saliva;tick transmission;tick-borne pathogen;Ticks;Tissues;tool;Transcript;transcriptome;transcriptomics;transmission process;Vaccines;vector;wound healing;Wound models;Yeasts

PROJECT_TITLE: Tick saliva and its importance for tick feeding and pathogen transmission


NIH_SPENDING_CATS: Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

PI_NAMEs: GROSHONG, ASHLEY  (contact)

PROJECT_TERMS: Ablation;Amino Acid Transporter;Amino Acids;Argasidae;Bacteria;bacterial metabolism;Bacterial Physiology;Binding;Binding Proteins;Blood;Borrelia;Borrelia burgdorferi;Case Study;cell motility;Characteristics;Complement;Complex;conventional therapy;Data;deprivation;differential expression;Disease;Environment;enzootic;Evolution;Genome;Genomics;Goals;Growth;Healthcare Systems;Homology Modeling;Human;Immune response;Incidence;Individual;Infection;Ingestion;Ixodes;Ixodidae;Larva;Life Cycle Stages;Lyme Disease;Maintenance;Mammals;Membrane Proteins;Modeling;Molting;Morphology;mortality;Mutagenesis;Nature;new therapeutic target;Nutrient;Nutritional;Oligopeptides;Order Spirochaetales;Ornithodoros;pathogen;Patients;peptide permease;Peptide Transport;Peptides;permissiveness;Peromyscus;Phase;Phenotype;Physiological;Physiological Adaptation;Population;Post Treatment Lyme Disease Syndrome;programs;Proliferating;Quality of life;Regulation;Relapse;Relapsing Fever;Reporting;response;Role;Source;Spirochaetales Infections;Symptoms;System;therapeutic development;tick-borne;Ticks;Tissues;transmission process;United States;uptake;vector;vector tick;Vector-transmitted infectious disease;White-Footed Mouse

PROJECT_TITLE: Borrelia burgdorferi nutrient acquisition throughout the enzootic cycle


NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Lung;Pediatric;Sleep Research

PI_NAMEs: MANTHIRAM, KALPANA  (contact)

PROJECT_TERMS: Adenitis;airway obstruction;Anatomy;Aphthous Stomatitis;Apnea;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Cervical;Child;Childhood;craniofacial;Craniofacial Abnormalities;Data;Deformity;Disease;Down-Regulation;Fever;Flare;Flow Cytometry;Gene Expression;Genes;Genetic Predisposition to Disease;Goals;Helper-Inducer T-Lymphocyte;Histology;IL17 gene;Immune;Immunologics;Immunology;Immunophenotyping;Inflammatory;Interferon Type II;Ionomycin;Myeloid Cells;Natural Killer Cells;Obstructive Sleep Apnea;Palatine Tonsil;Pathogenesis;Patients;Pediatric Surgical Procedures;Periodicals;peripheral blood;Pharyngitis;Population;Procedures;Recurrence;reduce symptoms;Sampling;Sleep Apnea Syndromes;Sorting;Structure of germinal center of lymph node;Susceptibility Gene;Syndrome;T-Cell Activation;Tonsil;Tonsillectomy;ventilation

PROJECT_TITLE: Immunology of Pediatric Tonsil Disorders


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;HIV/AIDS;Hepatitis;Hepatitis - C;Immunization;Infectious Diseases;Influenza;Liver Disease;Orphan Drug;Pneumonia and Influenza;Prevention;Rare Diseases;Vaccine Related;Vaccine Related - AIDS;Vector-Borne Diseases

PI_NAMEs: BONSIGNORI, MATTIA  (contact)

PROJECT_TERMS: 2019-nCoV;Affinity;Anti-viral Response;Antibodies;Antibody Repertoire;Antibody Therapy;Antibody-Dependent Enhancement;Antigens;Area;Avian Influenza A Virus;B-Lymphocytes;Binding Proteins;Cell Maturation;Clonal Expansion;cross reactivity;Dengue Virus;design;Development;Equilibrium;Evolution;experience;Flavivirus;Flavivirus Infections;Growth;Hepatitis C virus;HIV-1;Human;Humoral Immunities;Immune system;Immunity;Immunization;Immunobiology;Immunoglobulin M;Infection;Influenza;influenzavirus;information gathering;innovation;interest;Investigation;Licensing;Memory;Memory B-Lymphocyte;Modeling;Mutate;neutralizing antibody;nonhuman primate;novel;pathogen;pathogenic virus;Plasma Cells;Preventive vaccine;prophylactic;Regimen;Research;response;Role;Shapes;Specimen;translational goal;Vaccination;vaccine formulation;Vaccines;Virus;Virus Diseases;Zika Virus

PROJECT_TITLE: Origin and maturation of protective memory B cell responses against pathogenic viruses in natural infections and upon vaccination.


PI_NAMEs: GERMAIN, RONALD N (contact)

PROJECT_TERMS: Acceleration;adaptive immunity;Adaptor Signaling Protein;Anti-viral Agents;Anti-viral Response;Antigen-Antibody Complex;Binding;cell type;Cells;Cellular Immunity;Complex;computational pipelines;Computing Methodologies;Data;Disease;disease model;draining lymph node;Ebola virus;Elements;Environment;Event;experimental study;Generations;Genetic Predisposition to Disease;Goals;Health;Hematopoietic;Human;Immune response;Immunomodulators;In Vitro;in vivo;Individual;Infection;Infectious Agent;innovation;Interferon Type I;Interferons;Knock-out;Knowledge;Measurement;Methods;Mitochondria;Molecular;Mus;Output;pathogen;Pathogenesis;Pathway interactions;Play;preservation;prevent;Process;Productivity;protein biomarkers;Protein Deficiency;Proteins;receptor;Regulation;Resolution;response;RNA Viruses;Role;Sampling;Shapes;Signal Transduction;Signaling Protein;single-cell RNA sequencing;Site;Skin;Stains;Technology;temporal measurement;Testing;Therapeutic;Time;tissue fixing;Tissue imaging;Tissue Sample;Tissues;transcriptomics;Vesicular stomatitis Indiana virus;Viral;Virus;Virus Replication;Work;Zoonoses

PROJECT_TITLE: Determining the spatial-temporal and transcriptomic host response to emerging RNA viruses at a single cell resolution


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

PI_NAMEs: SAITO, TAIS B  (contact)

PROJECT_TERMS: Affect;Animals;Antigens;Arthropod Vectors;Arthropods;Bacteria;Behavior Therapy;Behavioral;Cells;Cutaneous;Dermal;Development;Disease;Disease Outcome;Disease Progression;Ehrlichia;Ehrlichiosis;Evaluation;Immune;Immune response;Immune signaling;Immunity;immunoregulation;Immunotherapy;in vivo;Infection;Infectious Skin Diseases;Infiltration;Inflammation;Inflammatory Infiltrate;Inflammatory Response;Injections;innovation;interest;Link;mouse model;Needles;Nerve Tissue;Nervous System;Outcome;pathogen;Pathogenesis;Pattern;Physiological;Physiology;Reaction;Research;response;Rickettsia Infections;Role;Severity of illness;Site;Skin;tick feeding;tick transmission;Ticks;Time;Tissues;transmission process;vector;vector tick;vector transmission;vector-borne infection

PROJECT_TITLE: Vector-pathogen-host interaction and immunopathogenesis of disease progression


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Pediatric;Prevention;Vaccine Related

PI_NAMEs: SCHWARTZBERG, PAMELA  (contact)

PROJECT_TERMS: 2019-nCoV;acute infection;adaptive immune response;Adenoidal structure;Anti-viral Response;Awareness;B-Lymphocytes;Blood;CD4 Positive T Lymphocytes;CD8B1 gene;cell motility;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Child;Clone Cells;COVID-19;CXCR3 gene;Epidemiology;Evaluation;Flow Cytometry;Goals;Helper-Inducer T-Lymphocyte;high dimensionality;Hispanic;Hospitals;Immune;Immune response;Immunity;Immunize;Immunoglobulin Class Switching;Immunoglobulin Somatic Hypermutation;Immunologic Memory;In Situ;Infection;insight;Interferon Type II;Intramuscular;Laryngoscopes;Lymphoid Tissue;Memory B-Lymphocyte;mucosal vaccine;Mucous Membrane;Nature;Operative Surgical Procedures;Oropharyngeal;Palatine Tonsil;pandemic disease;Participant;Patients;peripheral blood;Population;Poverty;Prevalence;programmed cell death protein 1;Reporting;response;Risk Factors;RNA vaccine;Sampling;SARS-CoV-2 infection;SARS-CoV-2 negative;SARS-CoV-2 spike protein;Serology test;Severe Acute Respiratory Syndrome;Site;Structure of germinal center of lymph node;T-Lymphocyte;Testing;tissue resident memory T cell;Tissues;Tonsil;Tonsillectomy;Upper respiratory tract;Vaccination;vaccine trial;viral RNA;Work

PROJECT_TITLE: Evaluation of Oropharyngeal responses to SARS-CoV-2


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Burden of Illness;Clinical Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases;Zika Virus

PI_NAMEs: KATZELNICK, LEAH  (contact)

PROJECT_TERMS: Adult;Aedes;Age;age related;age stratification;Antibodies;Antibody titer measurement;Antibody-Dependent Enhancement;Arboviruses;Area;Automobile Driving;Binding;Biological;Cambodia;Cells;Chikungunya virus;Child;Cities;Clinical;cohort;Collaborations;Collection;Computing Methodologies;Confidence Intervals;cross reactivity;Data;Dengue;Dengue Infection;Dengue Vaccine;Dengue Virus;Dengvaxia;Development;dimer;Disease;Disease Outbreaks;Disease Outcome;disorder risk;Dose;Ecuador;emerging virus;Enzyme-Linked Immunosorbent Assay;Epidemic;epidemiologic data;Epidemiologic Methods;Epidemiology;Epitopes;Evolution;experience;Extramural Activities;Flavivirus;geographic difference;Health;Herd Immunity;high risk;Hospitalization;Hospitals;Human;Immune;Immunity;Immunoglobulin G;Immunology;Immunology procedure;Incidence;Individual;Infection;insight;interdisciplinary approach;Manuscripts;Measurement;Measures;Michigan;Modeling;Nature;neutralizing antibody;Nicaragua;Nicaraguan;observational cohort study;Observational Study;Participant;Performance;Periodicals;Periodicity;Phase I Clinical Trials;Philippines;Population;Population Sizes;Predisposition;Prevention;Primary Infection;Printing;protective effect;Province;Publishing;Recording of previous events;Relative Risks;reproductive;Resolution;Risk;Role;rural area;Science;Scientific Advances and Accomplishments;Serology;Serotyping;severe dengue;sex;Shapes;Site;Statistical Methods;System;Testing;Thailand;Time;Titrations;United States National Institutes of Health;Universities;unvaccinated;urban area;Vaccinated;vaccine efficacy;vaccine safety;vaccine trial;Vaccines;vector;Viral Epidemiology;viral transmission;virology;Virus;Water;Work;ZIKA;Zika Virus;ZIKV infection

PROJECT_TITLE: Immunology, virology, and epidemiology of flaviviruses and other emerging viruses


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Pediatric;Prevention;Vaccine Related;Vector-Borne Diseases

PROJECT_TERMS: 15 year old;2019-nCoV;Adolescent;Affect;Age;aged;Animal Model;Antibodies;Antibody Response;Antibody titer measurement;B-Cell Antigen Receptor;betacoronavirus;Binding;Biological Assay;Cells;Cellular Immunity;Circulation;Collaborations;comparative;Coronavirus;COVID-19;COVID-19 pandemic;COVID-19 pandemic effects;COVID-19 vaccination;COVID-19 vaccine;Data Set;Dengue;Dengue Vaccine;Dengue Virus;Diamond;Enzyme-Linked Immunosorbent Assay;Epidemiology;Evaluation;Evolution;Exposure to;Ferrets;Flavivirus;Frequencies;Hamsters;Human;human coronavirus;human model;Immune;Immune Sera;Immunity;Immunologics;Immunology;Individual;Infection;Influenza;insight;interdisciplinary approach;Maps;Measures;Meta-Analysis;Methods;Mutation;neutralizing antibody;nonhuman primate;pandemic disease;Participant;pathogen;Persons;Philippines;pre-pandemic;Predisposition;Primary Infection;Printing;Publications;Publishing;PubMed;Random Allocation;receptor binding;response;Rest;Risk;Sampling;SARS-CoV-2 B.1.1.529;SARS-CoV-2 immunity;SARS-CoV-2 infection;SARS-CoV-2 negative;SARS-CoV-2 variant;Serology;seropositive;Seroprevalences;Serum;Testing;transmission process;Update;Vaccination;vaccine trial;Variant;Viral;Viral Epidemiology;Virus Diseases

PROJECT_TITLE: Epidemiology, immunology, and evolution of SARS-CoV-2 and other coronaviruses before and during the COVID-19 pandemic


NIH_SPENDING_CATS: Arthritis;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PI_NAMEs: FOX, JULIE  (contact)

PROJECT_TERMS: Acute;adaptive immune response;Alpha Virus;Alphavirus Infections;alphavirus receptor;Americas;Antibodies;Antibody Therapy;Antibody-mediated protection;Arthralgia;Arthritogenic;Attenuated;Australia;Chikungunya virus;Chronic;cross immunity;Culicidae;design;Development;Disease;Disease Outbreaks;Encephalitis;Exanthema;Fever;Geography;Goals;Headache;Human;IgG Receptors;Immune;Immunity;Individual;Infection;Innate Immune Response;Laboratories;Malaise;Mayaro virus;Mediating;Monoclonal Antibodies;monocyte;mortality;mouse model;Movement;Myalgia;Neurologic;novel therapeutics;novel vaccines;Pacific Islands;Pathogenesis;Pathogenicity;Polyarthralgias;Polyarthritides;prevent;RNA Viruses;Role;South America;System;Therapeutic;Therapeutic Monoclonal Antibodies;transmission process;Vaccine Design;Vaccines;Venezuelan Equine Encephalitis Virus;Venezuelan Equine Encephalomyelitis;Viral;Virus;Virus Diseases

PROJECT_TITLE: Mechanisms of immune-mediated protection and pathogenesis during viral infections


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Rare Diseases

PI_NAMEs: BEST, SONJA  (contact)

PROJECT_TERMS: animal model development;Anti-viral Therapy;Attenuated Vaccines;Case Fatality Rates;Cell Death;cell killing;Cell Line;Cell Survival;Cells;comparison control;CRISPR-mediated transcriptional activation;Data;Ebola virus;emerging virus;Genes;Genetic Transcription;genome wide screen;genome-wide;Goals;Guide RNA;helicase;Human;in vivo;Infection;Interferon Type I;Interferon-beta;Interferons;Life Cycle Stages;Liver;Medical;Methods;Microbe;Molecular;Mus;novel;Organ;promoter;Proteins;Public Health;RNA Viruses;Signal Transduction;Transcription Initiation;transmission process;Vaccine Design;Viral;Viral Genes;Viral Hemorrhagic Fevers;viral outbreak;Viral Pathogenesis;Viral Proteins;Virulence;Virus;Virus Diseases;Virus Replication;Zinc Fingers

PROJECT_TITLE: Genome-wide CRISPRa screen to determine the antiviral repertoire of the cell


NIH_SPENDING_CATS: Clinical Research;Genetics;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

PI_NAMEs: LACSINA, JOSHUA  (contact)

PROJECT_TERMS: Address;Apoptotic;Atlases;B-Lymphocytes;Biopsy;Biopsy Specimen;Bite;CD8-Positive T-Lymphocytes;cell type;Cells;Cellular Stress;Clinic;cohort;Collaborations;Cryopreservation;Cutaneous;Cutaneous Leishmaniasis;CXCL9 gene;CXCR3 gene;CXCR6 gene;Data;Data Set;deep learning algorithm;Dendritic Cells;Development;Devices;Dimensions;Disease;DNA;Enrollment;Equilibrium;Exhibits;Female;Fibroblasts;Frequencies;Gene Expression;Genes;Goals;Growth;Growth Factor;healing;Helper-Inducer T-Lymphocyte;heterogenous data;Human;IL7 gene;IL7R gene;Immune;Immune response;Immunity;Immunology;immunopathology;Infection;Infectious Skin Diseases;keratinocyte;Knowledge;Laboratories;Leishmania;Leishmaniasis;Lesion;Ligands;Lymphoid Cell;Macrophage;Maps;Mediating;MHC Class II Genes;monocyte;Morphologic artifacts;Mucocutaneous leishmaniasis;multiple omics;Myeloid Cells;National Institute of Allergy and Infectious Disease;neglected tropical diseases;novel;Parasites;participant enrollment;Pathogenesis;Patient Schedules;Patients;Phenotype;Phlebotominae;Pilot Projects;Population;Procedures;programs;Protocols documentation;Publishing;Punch Biopsy;Puncture biopsy;Quality Control;receptor;recruit;Regulatory T-Lymphocyte;Relapse;Research;RNA;Sampling;self supervised learning;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;Skin;Skin Tissue;Stromal Cells;System;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Th1 Cells;Time;Tissue Sample;transcriptome;transcriptome sequencing;transcriptomics;transmission process;United States National Institutes of Health;Universities;Vaccines;γδ T cells

PROJECT_TITLE: Defining human skin immunity to cutaneous leishmaniasis via systems immunology approaches


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Inflammatory Bowel Disease;Microbiome;Pediatric;Primary Immunodeficiencies;Rare Diseases

PI_NAMEs: HOURIGAN, SUCHITRA  (contact)

PROJECT_TERMS: Antibiotic Resistance;arm;associated symptom;Biological Products;Calendar;Chronic;Chronic Granulomatous Disease;Clinical;Clinical Trials;Colitis;Colonoscopy;congenital immunodeficiency;Data;design;Disease;effective therapy;Enrollment;Evaluation;fecal microbiome;fecal transplantation;Granulomatous disease;gut dysbiosis;gut inflammation;gut microbiota;Immune system;Immunomodulators;improved;Inflammation;Inflammatory Bowel Diseases;Inherited;Institutional Review Boards;Investigational New Drug Application;Investigational Therapies;Leukocyte L1 Antigen Complex;Measures;microbiome;open label;Participant;Pharmaceutical Preparations;Pilot Projects;pilot trial;Population;prospective;Randomized, Controlled Trials;Risk;Safety;Signal Transduction;Site;Symptoms;systemic inflammatory response;United States Food and Drug Administration;United States National Institutes of Health

PROJECT_TITLE: A pilot study of fecal microbiota transplantation for Chronic Granulomatous Disorder Associated Colitis (CGD-AC)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Vaccine Related

PROJECT_TERMS: 2019-nCoV;Animal Model;Antibodies;antibody test;Cessation of life;COVID-19;design;Development;Disease;efficacy evaluation;Evaluation;Goals;Hospitalization;immune activation;Immune response;Immunity;immunoregulation;In Vitro;in vivo;Infection;Inflammation;Inflammatory Response;Laboratories;Macrophage;Monoclonal Antibodies;Mutation;Neutralizing antibody assay;novel therapeutics;Pathogenesis;post SARS-CoV-2 infection;Primary Cell Cultures;protective efficacy;Reagent;recombinant virus;Respiratory Failure;Respiratory Tract Infections;response;SARS-CoV-2 immune response;SARS-CoV-2 infection;SARS-CoV-2 variant;Therapeutic;Treatment Protocols;Vaccination;Vaccines;Virus Diseases

PROJECT_TITLE: Pathogenesis and immunity during SARS-CoV-2 infection


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

PI_NAMEs: DOLAN, PATRICK  (contact)

PROJECT_TERMS: Animal Model;Biochemical;Biological;Biological Assay;Biophysics;Capsid;Cells;Code;Complex;Cultured Cells;Dengue Virus;Engineering;Enterovirus;Enterovirus 71;Environment;Evolution;Flavivirus;Future;Gene Expression;Genotype;Heterogeneity;Human;Immune response;In Vitro;in vivo;Infection;Intention;Libraries;Methods;Mutation;mutation screening;Pathogenesis;Phenotype;Population;Positioning Attribute;Printing;Process;programs;protein function;Proteins;Publishing;reconstruction;Recording of previous events;Research;RNA Viruses;Shapes;single cell sequencing;Structural Protein;Technology;tool;Viral;Viral Proteins;virology;Virus;Visit;West Nile virus;Work;Zika Virus

PROJECT_TITLE: Virus evolution and host responses in positive-sense RNA viruses


NIH_SPENDING_CATS: Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Maternal Health;Microbiome;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

PROJECT_TERMS: 2 year old;3 year old;abdominal fat;Adverse event;Animal Model;arm;beneficial microorganism;Birth;Body mass index;Cesarean section;Child Health;Clinical;Clinical Research;Clinical Trials;comparison control;Data;Data Collection;Development;Disease;Electronic Health Record;Engraftment;Enrollment;experimental arm;Exposure to;Feces;follow-up;Germ-Free;gut microbiota;Health;health of the mother;Health protection;high risk;Human;Immune;immune health;Immune response;Immune System Diseases;Infant;Inflammatory;Intervention;Intra-abdominal;Life;Link;maternal microbiome;Mediating;Metabolic;Metabolic Diseases;Methods;Microbe;microbiome;microbiome analysis;microbiome composition;microbiota composition;Mothers;Mus;neonate;Newborn Infant;normal microbiota;Obesity;obesity risk;offspring;Operative Surgical Procedures;Oral cavity;Outcome;Outcome Measure;Persons;phase 1 study;phase 2 study;Pilot Projects;primary outcome;Procedures;Randomized;Randomized, Controlled Trials;Regulation;Research Personnel;restoration;Safety;sample collection;Sampling;secondary outcome;Site;Skin;skin microbiota;Structure;Surveys;Swab;Testing;Transplantation;treatment arm;Vagina;vaginal microbiome;vaginal microbiota;Visit

PROJECT_TITLE: Vaginal microbiome seeding and health outcomes in Cesarean-delivered neonates: a randomized controlled trial


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Childhood Obesity;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Digestive Diseases;Eczema / Atopic Dermatitis;Emerging Infectious Diseases;Infectious Diseases;Maternal Health;Microbiome;Obesity;Pediatric;Prevention;Women's Health Research

PROJECT_TERMS: 2019-nCoV;Adult;Anti-Inflammatory Agents;Area;atopy;Bacteria;Bacteriophages;bariatric surgery;Cesarean section;Child;Childhood;Cholestasis;Clinical Research;Clostridium difficile;colonization resistance;COVID-19;Development;Disease;early childhood;Early identification;Eczema;Future;Goals;Health;host microbiome;Immune;Immune response;Impairment;Infection;Inflammatory;Inflammatory Bowel Diseases;insight;Life;Malignant Childhood Neoplasm;Metabolic;microbial;microbiome;Neonatal;Obesity;Observational Study;persistent symptom;Physiological;Regulation;Role;SARS-CoV-2 infection;Scientific Advances and Accomplishments;Shapes;skin microbiome;therapeutic target;Time;Vaginal delivery procedure

PROJECT_TITLE: The role of the microbiome in childhood disease