ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Services;Prevention;Primary Health Care;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Beneficiaries dually enrolled in Medicare and Medicaid have worse cancer outcomes compared to Medicare only beneficiaries, with lower screening rates, lower likelihood of receiving treatment, and higher risk of mortality. The Medicare Shared Savings Program is a delivery system reform that incentivizes healthcare providers and organizations to deliver coordinated, high-quality care. This proposed project will assess how much the Medicare Shared Savings Program improves cancer screening, time to treatment initiation after a cancer diagnosis, and cancer treatment costs for dually-enrolled beneficiaries.

PI_NAMEs: OH, NUL L (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: accountable care organization;Address;Affect;Age;age group;aged;Appointment;beneficiary;Breast;Breast Cancer Detection;Breast Cancer Treatment;burden of illness;cancer care;Cancer Detection;cancer diagnosis;cancer therapy;care coordination;Caring;Categories;Chronic;Clinical;clinical care;Clinical Skills;Colonoscopy;Colorectal;Colorectal Cancer;colorectal cancer screening;Complex;cost;Cost Analysis;Data;Data Set;Detection;Drug Prescriptions;dual eligible;Dual Enrollment;Early Diagnosis;Early treatment;Enrollment;Ensure;Event;Expenditure;experience;Fee-for-Service Plans;follow-up;Goals;Health;Health Expenditures;Health Personnel;Healthcare;high risk;High-Risk Cancer;Hospitalization;human old age (65+);improved;Incentives;Individual;Intention;Linear Models;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Measures;Medicaid;medical specialties;Medicare;Medicare claim;Medicare/Medicaid;Mentorship;Methods;Modeling;mortality;mortality risk;multiple chronic conditions;Newly Diagnosed;Organizational Models;Outcome;Outpatients;patient population;Patients;payment;Performance;Physicians;Policy Maker;programs;Provider;Quality of Care;Quasi-experiment;Regression Analysis;Research;Research Proposals;Sampling;Savings;Scientist;screening;Screening for cancer;screening guidelines;SEER Program;Services;skills;social;Survival Analysis;System;Thinking;Time;Training;Treatment Cost;treatment risk;Visit;Vulnerable Populations

PROJECT_TITLE: Detection and treatment of breast and colorectal cancer in dual eligible beneficiaries in the Medicare Sharing Savings Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-Z(20)]


ADMINISTERING_IC: AA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Substance Misuse

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative: Alcohol use disorder is a debilitating neuropsychiatric illness that often presents with significant anxiety, increasing the risk of relapse. The overall goal of this K23 proposal is to launch the career of the Principal Investigator, A. Benjamin Srivastava, MD, as an independent translational researcher who can combine clinical and cognitive neuroscience methods in order to understand the neural mechanisms underlying anxiety during early and protracted abstinence in alcohol use disorder. Ultimately, this patient- oriented research program will lead to both improvements in diagnosis and the identification of new treatment targets aimed improving outcomes in alcohol use disorder and co-occurring psychiatric illnesses.

PI_NAMEs: SRIVASTAVA, A B (contact)

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: Abstinence;addiction;Age;alcohol abstinence;alcohol use disorder;Anterior;Anxiety;anxiety states;anxiety symptoms;Area;behavior change;career;career development;Chronic;Chronic Disease;Clinical;Clinical Research;Clinical Trials;clinically relevant;clinically significant;cognitive control;cognitive neuroscience;Development;Diagnosis;Disulfiram;Doctor of Philosophy;drinking;Ensure;Equipment and supply inventories;experience;experimental study;Failure;Functional Imaging;Functional Magnetic Resonance Imaging;functional MRI scan;Future;Goals;Grant;Human;Impairment;improved;improved outcome;Individual;innovation;Insula of Reil;Learning;Magnetic Resonance Imaging;Measures;Mediating;Mental disorders;Mentored Patient-Oriented Research Career Development Award;Mentors;Methodology;Methods;Modeling;neural;neural circuit;neuromechanism;Neuronal Plasticity;neuropsychiatry;Neurosciences;novel;Output;Participant;patient oriented research;Patient Self-Report;physiologic stressor;Physiological;Population;Population Control;Prefrontal Cortex;Preparation;Principal Investigator;Process;programs;prolonged abstinence;Psychiatrist;Psychophysiology;Qualifying;recruit;Relapse;relapse risk;Research;response;Rest;Scanning;self-reported anxiety;skills;Stress;Structure of terminal stria nuclei of preoptic region;Substance Use Disorder;System;Time;Training;Training Programs;trait;translational scientist;Withdrawal;Writing

PROJECT_TITLE: Neural mechanisms of anxiety during early and protracted abstinence in alcohol use disorder

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Cannabidiol Research;Cannabinoid Research;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Natural Products;Pain Research;Substance Misuse;Therapeutic Cannabinoid Research

PHR: Project Narrative Many individuals use cannabis and cannabidiol (CBD), a constituent of cannabis, to treat their pain despite few empirical studies assessing their effects when used repeatedly or in combination. Pre-clinical studies show that CBD can attenuate the abuse-related effects of cannabis and enhance its analgesic efficacy but the effect of repeated CBD use on cannabis-induced analgesia and abuse liability in humans is not known. The primary goal of this mentored research proposal is to determine if daily CBD administration, across a range of doses and time, alters the abuse-related, reinforcing and analgesic effects of smoked cannabis.

PI_NAMEs: HARRIS, HANNAH MARIE (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Absence of pain sensation;abuse liability;Acute;Adult;American;Analgesics;Animal Model;antinociception;Attenuated;attenuation;Cannabidiol;Cannabinoids;Cannabis;Cannabis Abuse;career;central sensitization;chronic pain;Cigarette;Clinical;consumer demand;Data;Development;Dose;experience;Funding;Goals;healthy volunteer;Hour;Human;Individual;innovation;Laboratories;Laboratory Study;Mainstreaming;marijuana legalization;marijuana smoker;marijuana use;Measures;Medical;Mentors;Methodology;Modality;Modeling;Neurobiology;non-opioid analgesic;novel;Oral;Oral Administration;Pain;Pain management;pain perception;Participant;Pathway interactions;Pharmaceutical Preparations;Placebos;pre-clinical;pre-clinical research;preclinical study;Process;Property;Randomized;Research;Research Design;Research Personnel;Research Proposals;response;Scientist;Self Administration;Sensory;skills;Smoke;Spinal Cord;statistics;Study models;substance use;Techniques;Testing;Therapeutic Effect;Therapeutic Uses;Time;Training;Translating

PROJECT_TITLE: Effects of Repeated CBD Administration on Cannabis Abuse-Liability and Analgesia: A Human Laboratory Study

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: INDIANAPOLIS

ORG_NAME: RLR VA MEDICAL CENTER

ORG_STATE: IN

PHR: New policies and healthcare processes are constantly rolling out to the front lines of clinical staff and providers across the Veterans Health Administration (VHA). Less is known about the investment needed into evidence based implementation strategies by VHA healthcare organizations to achieve systematic implementation. Moreover, implementation science has only recently begun to identify a set of implementation strategies; however, the evidence and strength of the effects of such strategies are unknown. Dr. Damush and colleagues are designing and evaluating implementation strategies to activate individual and teams of clinical providers to implement evidence based processes to improve the quality of care and improve Veteran and provider satisfaction with VHA care. Our work will also contribute to the implementation science base of effective implementation strategies across multiple clinical conditions and settings to modify provider behavior to improve VHA care and the health-related quality of life outcomes for Veterans

PI_NAMEs: DAMUSH, TERESA M. (contact)

PROJECT_TERMS: Acute;acute stroke;Address;Adjuvant;appropriate dose;Area;Award;Back Pain;base;Behavior;Behavior Therapy;behavioral outcome;Cardiac rehabilitation;care outcomes;care systems;career;Caring;cerebrovascular;Certification;Chronic Disease;Client satisfaction;Clinical;clinical practice;Collaborations;contextual factors;County;Data;Data Analyses;Data Collection;Deimplementation;Department of Defense;design;Development;Dose;Effectiveness;electronic data;Electronics;Eligibility Determination;Emergency Medicine;Engineering;Enrollment;Evaluation;Event;evidence base;Evidence based practice;Feedback;formative assessment;Goals;Health;health care delivery;health care service organization;health related quality of life;Health Services;Healthcare;Healthcare Systems;Hospital safety;Hospitals;implementation context;implementation evaluation;implementation measures;implementation outcomes;implementation questions;implementation research;implementation science;implementation strategy;improved;Individual;Internal Medicine;Intervention;intervention mapping;Investments;Italy;Joints;Journals;Lead;Link;Low Back Pain;Measures;Medical Care Team;medical specialties;Mentors;Methods;Midwestern United States;Modeling;Monitor;multidisciplinary;Musculoskeletal Pain;Neurologic Deficit;Neurologist;Neurology;Nursing Staff;operation;Outcome;Pain;patient oriented;Patient-Focused Outcomes;Patients;peer support;Performance;Persons;Policies;Population;primary care provider;Process;programs;Provider;provider behavior;Psychologist;Public Health;Publications;Publishing;Quality of Care;Recovery;Reporting;Research;Research Personnel;response;Rural;Rural Health;Sampling;satisfaction;Scientist;Self Management;self-management program;Services;Standardization;Stroke;stroke recovery;Symptoms;System;telehealth;Telerobotics;telestroke;Testing;therapy development;tool;Training;Transient Ischemic Attack;Translations;Ultrasonography;usability;Veterans;Veterans Health Administration;virtual;Work

PROJECT_TITLE: Damush HSR&D Research Career Scientist Award Application

STUDY_SECTION_NAME: HSR-7 Capacity Building[HSR7]


ORG_CITY: TAMPA

ORG_NAME: JAMES A. HALEY VA MEDICAL CENTER

ORG_STATE: FL

PHR: Depression is the most prevalent mental health condition among VHA patients and is strongly associated with poor functioning, negative health outcomes, and suicide. Despite effective and available treatments, engagement in care is poor. This study will analyze VHA electronic medical record data, to identify patient characteristics associated with poor treatment engagement. The study will then develop and formatively evaluate an eHealth intervention to improve and sustain engagement in mental health care through self-monitoring. This is an important step in engaging Veterans who, in part, based on their military training, may have difficulty identifying or accepting depressed affect and the benefits of treatment. The information obtained will inform clinical strategies and operations policy to improve quality, coordination, and efficiency of mental health services.

PI_NAMEs: PANAITE, VANESSA  (contact)

PROJECT_TERMS: Address;Adherence;Affect;analytical tool;Awareness;behavioral health;Big Data;Big Data Methods;burden of illness;care outcomes;care seeking;Caring;Characteristics;Clinical;Computerized Medical Record;Data;data tools;Depressed mood;depressive symptoms;design;Development;Diagnostics Research;disability;Disease;Drops;Drug abuse;Economic Burden;Effectiveness of Interventions;effectiveness research;efficacy evaluation;eHealth;Electronic Health Record;Eligibility Determination;Evidence based treatment;experience;Feedback;formative assessment;Fostering;Foundations;Future;Goals;Guidelines;Health;health care service utilization;Health Services;Health Services Accessibility;Health Services Research;Healthcare;high risk;Impairment;Improve Access;improved;innovation;Intervention;intervention program;Knowledge;Link;Maintenance;Maps;Measurement;Medical;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Mentorship;Methodology;Methods;Military Personnel;military veteran;Modeling;Monitor;Moods;operation;Outcome;patient oriented;Patient risk;Patient Selection;Patients;Policies;poor health outcome;Post-Traumatic Stress Disorders;predictive modeling;Probability;Process;profiles in patients;programs;Provider;Recommendation;Research;Research Personnel;Research Priority;response;Retrospective cohort;Risk;Risk Factors;risk prediction model;Role;Self Efficacy;service intervention;skills;structured data;Suicide;suicide mortality;Support System;Symptoms;Technology;Testing;therapy design;therapy development;Time;tool;tool development;Training;Translating;treatment guidelines;treatment optimization;Treatment outcome;treatment response;uptake;Veterans;Work

PROJECT_TITLE: An eHealth intervention to increase depression treatment initiation and adherence among Veterans referred for mental health services

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Cost Effectiveness Research;Digestive Diseases;Pancreatic Cancer;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: Columbus

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Recent advances in imaging have led to the detection of innumerable pancreatic cysts that could never be seen before, now visible in >10% of patients who have an MRI and in >2% who have a CT scan for an unrelated reason. The majority of these cysts represent low-risk precursors of pancreatic cancer, a small percentage of which will progress to invasive cancer over months to years. In the proposed research, we will build a mathematical model that simulates the natural history of pancreatic cysts, and use it to formulate a management approach that optimally balances the benefits of cancer control with the risks and costs associated with overtesting and overtreatment.

PI_NAMEs: PANDHARIPANDE, PARI VIJAY (contact)

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Address;Advocate;Affect;Age;Biological Markers;Biopsy;Blood;Calibration;cancer care;Cancer Control;Cancer Etiology;cancer invasiveness;Cessation of life;Characteristics;Clinical;Clinical Trials;Clinical Trials Design;comorbidity;Complement;Computer Simulation;cost;cost effective;Cost Effectiveness Analysis;cost estimate;Cyst;Cyst Fluid;Data;Data Sources;Detection;Diagnosis;Endoscopic Ultrasonography;Equilibrium;experience;Frequencies;Future;General Hospitals;Goals;Guidelines;Harm Reduction;Health;Health Policy;Image;improved;Indolent;innovation;Intervention;Life Expectancy;Link;Literature;Magnetic Resonance Imaging;Malignant neoplasm of pancreas;Massachusetts;mathematical model;Medical Societies;Medicare;Methods;Modality;Modeling;models and simulation;Monitor;mortality risk;Mucinous Neoplasm;National Cancer Institute;Natural History;Observational Study;older patient;Operative Surgical Procedures;Outcomes Research;overtreatment;Pancreatectomy;Pancreatic Cyst;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Papillary;Pathway interactions;Patient Care;patient population;Patients;personalized approach;personalized management;prevent;Prognosis;Publishing;Recommendation;Reporting;Research;Risk;SEER Program;Serous Cystadenoma;surveillance imaging;X-Ray Computed Tomography

PROJECT_TITLE: Precision Management of Cystic Precursors to Pancreatic Cancer

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


ORG_CITY: ANN ARBOR

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: MI

PHR: Improving treatment access for Veterans with opioid use disorder (OUD) is a top VHA priority. With the national opioid crisis, many Veterans are suffering from OUD, which is associated with overdose, suicide and numerous other serious harms. Less than a third of Veterans with OUD receive evidence based pharmacotherapy treatment. Delivering treatment has been a major challenge due to a lack of trained providers in many VA facilities, particularly in community-based outpatient clinics (CBOCs). The current proposal will capitalize on the telehealth infrastructure in the VA to increase OUD treatment access by refining and then pilot testing a telehealth intervention delivering OUD treatment to Veterans in CBOCs and examine the VA OUD treatment landscape to understand where to best prioritize telehealth implementation. This research will inform the development of a telehealth intervention for OUD that can be implemented in the VHA and will inform future telehealth interventions to improve treatment for the large population of Veterans with substance use disorders.

PI_NAMEs: LIN, LEWEI ALLISON (contact)

PROJECT_TERMS: acceptability and feasibility;access disparities;addiction;Address;Administrator;Affect;Ambulatory Care Facilities;Area;Buprenorphine;Caring;Chronic;Clinic;Clinical;Clinical Services;Communication;Communities;Data;design;Development;effective therapy;effectiveness testing;evidence base;Evidence based treatment;experience;follow-up;Future;Goals;Health Services;Health Services Accessibility;Health Services Research;Healthcare Systems;implementation evaluation;implementation science;Improve Access;improved;improved outcome;Infrastructure;innovation;interest;Intervention;intervention delivery;intervention refinement;Intervention Trial;Interview;Location;Medical center;Mental disorders;Mentorship;Methods;military veteran;Modeling;multilevel analysis;novel;Opioid;opioid epidemic;opioid use;opioid use disorder;Outcome;Overdose;Participant;patient engagement;Patients;Perception;Persons;Pharmaceutical Preparations;Pharmacotherapy;Pilot Projects;pilot test;pilot trial;Prevalence;prevent;programs;Protocols documentation;Provider;Randomized;Reporting;Research;Research Activity;Research Personnel;Research Priority;Site;Specialist;Structure;substance use;Substance Use Disorder;Suicide;Surveys;telehealth;telehealth systems;Testing;Time;Training;treatment and outcome;treatment as usual;Variant;Veterans

PROJECT_TITLE: Using telehealth to expand treatment access for Veterans with opioid use disorder


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: BOSTON

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative While the sensory neurons and brain circuitry underlying vision, hearing, and the chemical senses (taste and smell) had been deeply explored, less is known about the sense of touch. We have generated an array of mouse genetic tools that have enabled detailed investigation into the principal classes of low-threshold and high-threshold mechanosensory neuron subtypes (LTMRs and HTMRs) and the central touch circuitry. We are using these tools and a range of new physiological, behavioral, and anatomical approaches to elucidate the properties and functions of LTMR and HTMR subtypes across different skin regions and the functional organization of the subcortical touch circuitry, in health and disease.

PI_NAMEs: GINTY, DAVID D (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TITLE: Elucidating Cutaneous Mechanosensory Circuits, from Development to Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-H (26)]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

PHR: Project Narrative Immunotherapies targeting the cell surface proteins expressed on cancer cells have revolutionized the treatment of B-cell Acute Lymphoblastic Leukemia (B-ALL). However, B-ALLs that contain gain-of-function oncogenic mutations involving the KMT2A gene remain high risk, and often transition to an Acute Myeloid Leukemia (AML) identity, resulting in loss of the immunotherapeutic targets and aggressive tumor relapses that are usually fatal. This proposal takes an integrated approach to (1) identify clinically available pharmaceuticals that can limit the ability of KMT2A mutant B-ALLs to switch to an AML identity and (2) identify novel biomarkers that label the subset of KMT2A mutant leukemias that remain high risk, and can be used to develop more effective immunotherapies in the future.

PI_NAMEs: JANSSENS, DEREK HENRY (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: Acute leukemia;Acute Lymphocytic Leukemia;Acute Myelocytic Leukemia;Address;Atlases;B-Cell Acute Lymphoblastic Leukemia;B-cell precursor acute lymphoblastic leukemia cell;Bar Codes;Binding Sites;Biological Assay;cancer cell;candidate identification;candidate marker;CD19 gene;CD34 gene;Cell Fraction;Cell Line;Cell Nucleus;Cell surface;Cell Surface Proteins;cell type;Cells;Chimeric Proteins;Chromatin;Chromatin Remodeling Factor;Chromosomal translocation;Clinical;Collaborations;Collection;combinatorial;comparative genomics;design;Development;Developmental Gene;Disease remission;Equilibrium;Event;Exhibits;experimental study;Future;gain of function;Gene Expression Regulation;gene network;gene regulatory network;Gene Structure;Genes;Genetic;Genetic Transcription;genome-wide;Genomics;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Heterogeneity;high risk;Human;Immunofluorescence Immunologic;Immunotherapeutic agent;Immunotherapy;improved;indexing;Individual;Infant;insight;Institution;Label;lentivirally transduced;leukemia;Leukemic Cell;leukemic transformation;Lysine;Maps;Methods;Methyltransferase;Mixed-Lineage Leukemia;MLL gene;MLLT2 gene;MLLT3 gene;mutant;Mutation;Nature;non-genetic;novel;novel marker;novel therapeutic intervention;Oncogenic;Oncoproteins;overexpression;Patients;Pattern;Pharmacologic Substance;Phenotype;Postdoctoral Fellow;prevent;Principal Investigator;Prognosis;programs;Publishing;Recurrence;Regulation;Relapse;Repression;Research;Research Personnel;response;RNA-Binding Proteins;Role;Sampling;small molecule;stathmin;Target Populations;targeted treatment;Testing;Time;tool;transcription factor;treatment strategy;tumor;tumor heterogeneity;Umbilical Cord Blood

PROJECT_TITLE: Oncoprotein-regulated lineage plasticity in acute leukemia

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-R (J1)]


ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

ORG_STATE: CA

PHR: Hoarding Disorder (HD) is serious and disabling in Veterans. Present in up to 7% of Veterans and even higher symptom rates in older Veterans; HD contributes to functional impairment and poor quality of life. Cognitive Rehabilitation and Exposure/Sorting Therapy (CREST) has shown promising functional improvement and symptom reduction. To reduce burdens and barriers to implementation of CREST, the proposed project will individualize CREST based on cognitive testing and participant preferences, provide all care in the participant’s home through telemedicine and home visits, and shorten the timeframe of treatment. A randomized controlled trial comparing 24 sessions of Personalized-CREST to case management for 130 adult Veterans with HD is proposed. Multifaceted functional and recovery outcomes including quality of life, HD severity, and sustained recovery outcomes will be examined throughout treatment and follow-up. By advancing our knowledge of the rehabilitative care of HD, we can interrupt the trajectory of this chronic and debilitating condition.

PI_NAMEs: AYERS, CATHERINE  (contact)

PROJECT_TERMS: Activities of Daily Living;Address;Adult;Aftercare;Age;care delivery;Caregiver Burden;Caring;Case Management;Chronic;Clinic;clinical practice;Clutterings;Cognitive;cognitive rehabilitation;cognitive testing;Communities;Compulsive Hoarding;Dangerousness;Data;Decision Making;design;disability;Disabling;Disease;Distress;Economic Factors;Evaluation;Evidence based treatment;Executive Dysfunction;executive function;experience;fall risk;Fire - disasters;follow-up;Food Contamination;functional disability;Functional impairment;functional improvement;functional outcomes;Gender;Home;Home visitation;Housing;human old age (65+);Impairment;implementation barriers;improved;Individual;Individual Differences;innovation;Interruption;Intervention;Knowledge;Left;Life;Measures;Mediating;Mediation;Medical;Mental Health;Modality;Nature;novel strategies;nutrient deprivation;older adult;Older Population;Outcome;Participant;Pharmaceutical Preparations;precision medicine;preference;Primary Care;primary outcome;programs;psychiatric comorbidity;Public Health;Quality of life;Randomized, Controlled Trials;Recovery;reduce symptoms;Rehabilitation Outcome;Rehabilitation therapy;rehabilitative care;Research;secondary outcome;Services;Severities;Site;Social isolation;Social Workers;Sorting;standard of care;sustained recovery;Symptoms;Telemedicine;Telemental;Therapeutic Intervention;Training;Treatment Factor;Treatment outcome;trial comparing;Veterans;Visit

PROJECT_TITLE: Functional and Cognitive Rehabilitation of Hoarding Disorder

STUDY_SECTION_NAME: Behavioral Health & Social Reintegration[RRD4]


ORG_CITY: HUNTINGTON

ORG_NAME: HUNTINGTON VETERANS AFFAIRS MED CTR

ORG_STATE: WV

PHR: Pre-deployment hazardous binge drinking is highly prevalent in active-duty US military personnel and can increase the likelihood of developing an alcohol use disorder. This is particularly relevant to combat veterans who increasingly treat symptoms of depression and anxiety by ‘self-medicating’ with alcohol. This research furthers the VA mission by identifying novel non-neuronal mechanisms that are involved in the dysregulation of neuronal activity and subsequent neuronal remodeling that occurs after binge ethanol exposure. Understanding these mechanisms in the context of synaptic dysfunction and the emergence of alcohol use disorder could lead to the development of novel pharmacotherapies designed to break the cycle of chronic substance abuse in this at-risk population.

PI_NAMEs: RISHER, MARY-LOUISE  (contact)

PROJECT_TERMS: active duty;Acute;Affect;Afghanistan;Age;aged;Alcohol abuse;alcohol abuse therapy;alcohol exposure;alcohol misuse;alcohol use disorder;Alcohols;anxiety symptoms;Astrocytes;Automobile Driving;Behavior;Behavioral;binge drinking;Cells;Central Nervous System;Chronic;Cognitive deficits;combat veteran;Communication;Consumption;Coupling;Data;Dendritic Spines;depressive symptoms;design;Development;drinking;drinking behavior;Drug Exposure;Electron Microscopy;Electrophysiology (science);Ethanol;Female;Freedom;Fright;Functional disorder;Goals;hazardous drinking;Health;Hippocampus;Homeostasis;Hyperactivity;Immunohistochemistry;Impaired cognition;Impairment;In Vitro;in vivo;Induced Neurons;innovation;insight;Ions;Knowledge;Label;Learning;Link;Long-Term Effects;male;Mediating;Mediator;member;Memory impairment;Military Personnel;military veteran;Mission;Modeling;Molecular;Morphology;neuronal circuitry;Neurons;novel;operation;Output;peer;Pharmacotherapy;Population;Populations at Risk;Positioning Attribute;Prevalence;prevent;Prevention;Process;Rattus;Regulation;Reporting;Research;Research Personnel;resilience;Risk;Risk Factors;Role;Short-Term Memory;Signal Transduction;Site;Slice;spatiotemporal;Structure;Substance abuse problem;Surveys;symptom treatment;Synapses;synaptic function;Synaptic Transmission;targeted treatment;Vertebral column;Veterans;Viral;Vulnerable Populations

PROJECT_TITLE: Long-term effects of binge drinking on astrocyte-synaptic interactions


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: IOWA CITY

ORG_NAME: IOWA CITY VA MEDICAL CENTER

ORG_STATE: IA

PHR: The Center for the Prevention and Treatment of Visual Loss (CPTVL) provides new discoveries for restoring vision and related brain functions, which are important to a Veteran's interpretation of their environment, daily productivity, and quality of life. This is done through a creative and scientifically rigorous interaction between clinicians and scientists who perform research in three main focus areas: Telemedicine, Cellular Mechanisms of Disease, and Novel Therapeutics. Research is translated into goals of rehabilitating and restoring visual function, thus enhancing the quality of life of Veterans. Examples of disorders that are targeted for rehabilitation include glaucoma, diabetic retinopathy, diabetic peripheral neuropathy, macular degeneration, traumatic brain injury, optic neuropathy, multiple sclerosis, light sensitivity, and migraine. Enabling smartphone devices for home testing of function enhances rehabilitation of these disorders.

PI_NAMEs: KARDON, RANDY H. (contact);KUEHN, MARKUS H.

PROJECT_TERMS: 3-Dimensional;Affect;Area;Artificial Intelligence;Biological Markers;Blindness;Blinking;Brain;Cardiovascular system;Central Nervous System;Central Nervous System Diseases;Cities;clinical implementation;clinically relevant;Creativeness;Dedications;diabetic;Diabetic Retinopathy;Diagnosis;Disabling condition;Disease;Early Diagnosis;Environment;Esthesia;Eye;Eye diseases;Eye Movements;Eyelid structure;Facial Muscles;General Population;Glaucoma;Goals;home test;Imaging Device;Immune system;improved;innovation;insight;Iowa;Link;Machine Learning;Macular degeneration;Manufacturer;Mediating;Migraine;military veteran;Mission;Monitor;Morbidity - disease rate;Movement;Multiple Sclerosis;Nervous System;Nervous System Disorder;Nervous System Physiology;Neuro-Ocular System;Neurologic;novel therapeutics;ocular imaging;optic nerve disorder;Outcome Measure;Pain;Peripheral Nervous System Diseases;personalized medicine;Pharmacologic Substance;Photophobia;Prevention;Productivity;Pupil;Quality of life;Reflex action;Reflex eye movement;Rehabilitation therapy;Research;Scientist;Sensory;sight restoration;smartphone based device;Staging;Structure;Technology;Telemedicine;Testing;Therapeutic;therapeutic target;Translating;translational framework;Traumatic Brain Injury;treatment response;Veterans;Vision;Vision Disorders;Visual Perception;Visual System

STUDY_SECTION: RRDC

STUDY_SECTION_NAME: Centers, Research Enhancement Award Program and Consortiums[RRDC]


NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Headaches;Migraine;Neurosciences;Pain Research

ORG_CITY: DURHAM

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Current treatments for debilitating chronic pain and itch conditions are limited. Our proposed structural, mechanistic, and pharmacological studies of sensory receptors will set a cornerstone for the future development of therapeutics to treat pain and/or itch- related disease conditions.

PI_NAMEs: LEE, SEOK-YONG  (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Biology;Brain;Chemicals;chronic itch;chronic pain;Computational Biology;design;Detection;Disease;Drug Targeting;Future;Ion Channel;Irritants;Membrane;Migraine;Modeling;Molecular;Mutation;Neurobiology;Neurons;Nociception;non-opioid analgesic;Pain;Perception;pharmacologic;Pharmacology;Pharmacology Study;Pruritus;receptor;Research;Sensory;sensory integration;Sensory Receptors;Signal Pathway;Signal Transduction;small molecule;somatosensory;Spinal Cord;Stimulus;Structure;Temperature;therapeutic development;transmission process

PROJECT_TITLE: Structure, function, and pharmacology of sensory receptors


NIH_SPENDING_CATS: Chronic Pain;Genetics;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Women's Health Research

ORG_DEPT: PHARMACOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE : The project applies murine models of nerve injury and peripheral inflammation to investigate female-specific cellular mechanisms of long- term pain. Information from this work will help developing novel, tailored and more efficacious treatments for chronic pain conditions.

PI_NAMEs: ZACHARIOU, VENETIA  (contact)

PROJECT_TERMS: Absence of pain sensation;Acute Pain;adeno-associated viral vector;Affect;Affinity Chromatography;Attenuated;Behavior;Biochemical;Biochemistry;Biological Assay;Brain;Cell Surface Receptors;central pain;central sensitization;chromatin immunoprecipitation;chronic pain;chronic pain management;chronic painful condition;Data;efficacious treatment;Electrophysiology (science);Elements;Enterobacteria phage P1 Cre recombinase;Estrogen Nuclear Receptor;Female;Fractionation;G-Protein-Coupled Receptors;Gene Expression;Gene Silencing;Genes;Genetic;Genetic Transcription;Golgi Apparatus;Gonadal Hormones;GTP Phosphohydrolase Activators;GTP-Binding Protein Regulators;Hypersensitivity;Immunofluorescence Immunologic;In Situ;Inflammation;inflammatory pain;knock-down;knockout gene;Label;LoxP-flanked allele;Maintenance;male;mechanical allodynia;Mediating;men;Messenger RNA;Methodology;midbrain central gray substance;Modeling;Molecular;Monitor;mouse model;Mus;nerve injury;Neuroanatomy;Neurons;next generation;Nociception;Norepinephrine;Norepinephrine Receptors;novel;overexpression;Pain;pain model;pain processing;painful neuropathy;patch clamp;Pathologic;Pathway interactions;Pattern;Perception;Peripheral;Peripheral nerve injury;pharmacologic;Physiological;Play;Property;protein expression;Proteins;receptor;receptor binding;reduce symptoms;Regulation;response;RGS1 gene;Ribosomes;Role;Sensory;Serotonin;serotonin receptor;sex;Signal Transduction;Spinal Cord Plasticity;Symptoms;Testing;Thermal Hyperalgesias;Transcript;transcriptome sequencing;Translating;transmission process;vector;Viral Vector;Western Blotting;Woman;Work

PROJECT_TITLE: A Female Specific Role of RGSz1 in Modulation of Chronic Pain

STUDY_SECTION: MIST

STUDY_SECTION_NAME: Molecular and Integrative Signal Transduction Study Section[MIST]


ORG_CITY: MADISON

ORG_NAME: WM S. MIDDLETON MEMORIAL VETERANS HOSP

ORG_STATE: WI

PHR: Over 40% of Veterans have obesity, a condition associated with multiple comorbidities and high healthcare costs. While lifestyle interventions addressing dietary change and physical activity produce clinically significant weight loss, many individuals experience weight regain due to decreased adherence to these changes. In this two-arm, randomized trial, Veterans with obesity and a cohabitating adult support person will be randomized to participate in a virtual weight loss intervention based on the VA’s MOVE! program with or without their support person. Those who participate with their partner will learn and practice communication and support skills. We predict that the dyadic intervention will result in greater weight loss, improved social support, and enhanced quality of life at 72 weeks compared to the patient-focused intervention. If effective, the support intervention will contribute to the identification and implementation of successful, evidence-based approaches to reduce the prevalence of obesity and associated comorbidities among Veterans.

PI_NAMEs: VOILS, CORRINE IONE (contact)

PROJECT_TERMS: Address;Adherence;Adult;arm;Behavior Therapy;Behavioral;Body Weight decreased;Cholesterol;Chronic Disease;Clinical;Clinical Trials;clinically significant;Cognitive;Collaborations;Communication;comorbidity;Counseling;Couples Therapy;dietary;Dietary intake;Early Intervention;Educational Curriculum;Educational process of instructing;efficacy evaluation;evidence base;Exercise;Expectancy;experience;Feeling;Future;future implementation;Goals;Health;Health behavior change;Health Care Costs;Health Services Research;Home;implementation evaluation;implementation outcomes;improved;indexing;Individual;innovation;insight;Intervention;intervention effect;Interview;Joints;Learning;Life Style;lifestyle intervention;Maintenance;Mediating;Mediator;Medical;Methodology;Motivation;Obesity;Outcome;Participant;Patient-Focused Outcomes;Patients;Perception;Persons;Physical activity;Prevalence;primary care practice;primary endpoint;primary outcome;Problem Solving;programs;Quality of life;Randomized;randomized trial;research and development;Risk Factors;secondary outcome;skills;Social Environment;Social Network;Social support;Spouses;success;Surveys;symposium;technology platform;theories;Thinking;Time;treatment as usual;two-arm trial;United States Department of Veterans Affairs;Veterans;virtual;virtual healthcare;virtual technology;Weight;weight loss intervention;Weight maintenance regimen;Work

PROJECT_TITLE: Collaborate2Lose: Collaborating with romantic and non-romantic support persons to improve long-term weight loss

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Orphan Drug;Precision Medicine;Radiation Oncology;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Tumor Treating Fields (TTFields) are a novel electric field therapy to treat glioblastoma, a deadly brain cancer. Currently, only solid/contrast enhancing regions of tumors are selected to deliver TTFields completely overlooking the infiltrative neoplastic components wheretumor recurrence is inevitably observed. To address this inadequacy in the treatment plan, we are proposing to use whole brain spectroscopy derived metabolic maps for better delineating the boundaries of these infiltrative tumors and subsequently employing sophisticated tools to ensure enhanced delivery of TTFields to the entire viable tumor bed in an effort to improve overall patient outcomes.

PI_NAMEs: CHAWLA, SANJEEV ;MOHAN, SUYASH  (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Address;Adverse effects;Antimitotic Agents;arm;Beds;Brain;Brain region;cancer cell;cell killing;Cell Proliferation;chemoradiation;chemotherapeutic agent;Choline;Clinical;clinical efficacy;clinical practice;Clinical Trials;Computer Models;contrast enhanced;design;Diffusion;Dose;dosimetry;electric field;Ensure;FDA approved;follow-up;Glioblastoma;Goals;health related quality of life;Image;imaging modality;Immunotherapy;improved;indexing;individual patient;Industrialization;industry partner;inter-individual variation;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Malignant neoplasm of brain;Malignant Neoplasms;Maps;Measures;Metabolic;Methods;Microscopic;Modality;Modeling;multimodality;Multiparametric Analysis;N-acetylaspartate;neoplastic;neoplastic cell;neuroimaging;Neurons;novel;optimal treatments;Outcome;Parameter Estimation;participant enrollment;patient response;Patient-Focused Outcomes;Patients;Perfusion;personalized diagnostics;personalized medicine;personalized therapeutic;Positioning Attribute;Primary Brain Neoplasms;profiles in patients;Prognosis;Proliferating;Protons;Quality of life;Radiation Injuries;Radiation therapy;radiological imaging;Randomized;recruit;Recurrence;Recurrent tumor;Reporting;response;Scalp structure;Solid;spectroscopic imaging;Spectrum Analysis;standard of care;survival outcome;temozolomide;Therapeutic;Time;tool;Transducers;treatment arm;treatment comparison;treatment planning;treatment response;tumor;Tumor Cell Invasion;two-arm study

PROJECT_TITLE: Whole-brain Spectroscopy Guided Personalized Mapping of Transducer Arrays for Glioblastoma Patients Receiving Tumor Treating Fields


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative The proposed research is relevant to public health because it will not only reveal critical molecular insights into the role of ARID1A mutation in cancer and particularly ovarian cancer, but also provide a scientific rationale for developing urgently needed new pre-clinical therapeutic strategies for this disease. These studies will also serve as a prototype for other epigenetic therapeutic strategies for cancers with genetic alterations in other regulators of chromatin structure, a well-recognized feature of many cancer types. Therefore, the proposed research is relevant to NIH’s mission in terms of developing fundamental knowledge that will reduce the burden of human illness.

PI_NAMEs: ZHANG, RUGANG  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: anti-PD-L1;anti-PD-L1 antibodies;anti-PD-L1 therapy;Apoptotic;ARID1A gene;ATF6 gene;Beds;biological adaptation to stress;cancer cell;cancer subtypes;cancer type;cell growth;Cell Line;Cell Survival;Cells;Cessation of life;chemotherapy;Chromatin Remodeling Factor;Chromatin Structure;Clinical;clinically relevant;cytotoxic CD8 T cells;Data;Dependence;Development;Diagnosis;Disease;effective therapy;endoplasmic reticulum stress;Epigenetic Process;Epithelial ovarian cancer;experimental study;feature detection;gene repression;Genes;Genetic;genetic makeup;Genetic Transcription;genome-wide;Goals;Growth;Human;immune checkpoint blockade;Immunocompetent;inhibitor;innovation;insight;Intervention;Knock-out;Knowledge;LoxP-flanked allele;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Messenger RNA;Methods;Mission;Modality;Molecular;mouse model;mutant;Mutate;Mutation;neoplastic cell;novel;novel therapeutic intervention;Nucleotides;Ovarian Clear Cell Tumor;Ovarian Endometrioid Adenocarcinoma;Pathway interactions;patient derived xenograft model;Platinum;pre-clinical;Pre-Clinical Model;precision medicine;Primary Neoplasm;Prognosis;Proteins;prototype;Public Health;Refractory;Repression;Research;Resolution;response;Ribonucleases;RNA Splicing;Role;Series;small molecule;small molecule inhibitor;synergism;T-Cell Activation;Testing;Therapeutic;transcription factor;tumor;Tumor Immunity;Tumor Suppressor Proteins;United States National Institutes of Health;Up-Regulation;XBP1 gene;Xenograft procedure

PROJECT_TITLE: Mechanistic basis and therapeutic strategies for ARID1A mutation in ovarian cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Immunization;Immunotherapy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Vaccine Related

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative Adaptive immune receptors (i.e. antibodies and T cell receptors) enable our body to fight off disease, “remember” pathogens, and train the immune system through vaccination. Immunologists have learned via high‐throughput sequencing that adaptive immune receptors have a truly remarkable diversity. In this proposal, we develop machine‐learning methods for these sequence data, which will allow us to predict the maturation, statistical distribution, and binding properties of adaptive immune receptors, and thus to better design vaccinations, autoimmune disease treatment, and immunotherapy treatment for cancer.

PI_NAMEs: MATSEN, FREDERICK ALBERT (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: 3-Dimensional;algorithm training;Algorithms;analytical tool;Antibodies;Antibody Affinity;Antibody Repertoire;Antigens;Architecture;Autoimmune Diseases;Automobile Driving;Big Data;Binding;Biochemical;biochemical model;Biochemical Process;cancer immunotherapy;cancer therapy;Categories;Cell Line;Characteristics;Collection;Complex;complex data;Data;data complexity;Data Set;deep learning;deep learning model;deep neural network;deep sequencing;Dependence;design;Diagnosis;Disease;Entropy;Evolution;experimental study;Exposure to;fighting;Foundations;functional group;Gene Conversion;Generations;generative models;Goals;High-Throughput DNA Sequencing;High-Throughput Nucleotide Sequencing;Human;Hybrids;Immune;Immune response;Immune system;Immunoglobulin Somatic Hypermutation;Immunologic Memory;Immunologic Receptors;Immunologics;Immunologist;Immunology;Immunotherapy;In Vitro;in vivo;Individual;Knock-out;Knowledge;Laboratories;large datasets;Learning;Machine Learning;machine learning method;markov model;Medical;member;Methods;model organism;Modeling;Modification;Mutation;pathogen;Pathway interactions;Population;Procedures;Process;progenitor;Property;Prophylactic treatment;receptor;repaired;Resolution;response;Sampling;Science;Statistical Distributions;Statistical Methods;Statistical Models;success;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Techniques;Technology;Testing;Time;tool;Training;Update;V(D)J Recombination;Vaccination;Vaccine Design;Vaccines;Validation;Work

PROJECT_TITLE: Blending deep learning with probabilistic mechanistic models to predict and understand the evolution and function of adaptive immune receptors

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ADMINISTERING_IC: MH

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Data Science;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: The proposal is to enhance the DANDI archive, an easy to use infrastructure for scientists to share, collaborate, and process data from neurophysiology experiments, which in turn form the basis for understanding cellular level mechanisms of brain function. Performing the proposed research will improve the archive to prepare it for the challenges arising from the significant growth of neuroscientific data. Such open data helps to increase collaboration and benefits researchers, but can also be used as educational materials in high schools and colleges. An open archive will facilitate data publishing and improve access by scientific communities across the world, and can accelerate scientific discoveries about the nervous system.

PI_NAMEs: GHOSH, SATRAJIT SUJIT (contact);HALCHENKO, YAROSLAV O

PROGRAM_OFFICER_NAME: KIM, DOUGLAS SUN-IL

PROJECT_TERMS: Acceleration;Archives;Award;base;Brain;Brain imaging;BRAIN initiative;Brain region;Collaborations;college;Communities;community engagement;Complex;Computer software;Consumption;Data;Data Analyses;data dissemination;data ingestion;data integration;data interoperability;data management;data reuse;Data Set;data sharing;data standards;Data Storage and Retrieval;data streams;data structure;Decision Making;Development;Devices;Disease;distributed archives;diverse data;Ecosystem;Educational Materials;Educational workshop;Encapsulated;experience;experimental study;FAIR principles;Future;Growth;high school;Improve Access;improved;Individual;Informatics;Infrastructure;insight;interactive computing;interest;Internet;interoperability;Knowledge;large datasets;Link;Metadata;Modality;Modeling;multimodal data;multimodality;Nervous System;neurophysiology;Neurosciences;Neurosciences Research;next generation;Online Systems;open data;petabyte;Phase;preservation;Process;prospective;Publications;Publishing;Research;Research Personnel;Research Project Grants;Route;Science;Scientific Inquiry;Scientist;Services;Software Engineering;Software Tools;Standardization;Structure;Technology;Thinking;tool;Training;United States National Institutes of Health;Work

PROJECT_TITLE: DANDI: Distributed Archives for Neurophysiology Data Integration

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-L (01)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Prevention;Substance Misuse

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Concerned partners (CPs) are a powerful and often underutilized source of influence for individuals who misuse alcohol. This project will: (1) identify specific behaviors enacted by CPs that relate to increases and decreases in their partner’s drinking behaviors; (2) use that information to develop a web-based intervention for CPs; and (3) evaluate the success of this intervention in reducing drinking and related problems.

PI_NAMEs: OSILLA, KAREN CHAN (contact);RODRIGUEZ, LINDSEY

PROGRAM_OFFICER_NAME: BALACHOVA, TATIANA NIKOLAYEVNA

PROJECT_TERMS: acceptability and feasibility;Address;Affect;Al-Anon;alcohol abuse therapy;Alcohol consumption;alcohol craving;alcohol misuse;alcohol use disorder;Alcohols;Anger;Anxiety;Behavior;behavior influence;Behavior Therapy;care seeking;Caring;catalyst;Clinical;Communication;communication behavior;Communities;comparison control;Conflict (Psychology);Consumption;Couples;craving;Data;Data Collection;design;deter alcohol use;Development;Distress;Domestic Violence;drinking;drinking behavior;Ecological momentary assessment;Education;Educational process of instructing;experience;Family;Family psychotherapy;Feedback;follow-up;Future;Goals;Health Services Accessibility;help-seeking behavior;Home;improved;Individual;innovation;insight;Internet;Intervention;Knowledge;Lead;Learning;loved ones;Maintenance;Mental Depression;Mental Health;Modeling;Outcome;Outcomes Research;Partner Communications;Pattern;Personal Satisfaction;Persons;physical conditioning;Play;prevent;Prevention;psychoeducation;Psychological reinforcement;Public Health;Punishment;Randomized, Controlled Trials;recruit;Reporting;Research;Resources;response;Rewards;Role;Sampling;Severities;sexual assault;sobriety;social media;Social support;Source;success;Surveys;Techniques;technology intervention;Testing;Time;tool;treatment comparison;Treatment Efficacy;trial comparing;web-based intervention

PROJECT_TITLE: Using ecological momentary data to inform a web-intervention for romantic partners concerned about their loved ones drinking

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Hypertension;Kidney Disease;Prevention

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: This proposal will use kidney SPECT/CT of Tc-99m-tilmanocept to evaluate the mesangial changes seen in diabetics across the spectrum of kidney disease as well as persons with hypertensive kidney disease, the next most common cause of kidney disease in patients with diabetes. We aim to demonstrate that these different disease types and stages can be differentiated with Tc-99m-tilmanocept SPECT/CT and can thus be used for future trials evaluating early diagnosis and treatment of diabetic nephropathy.

PI_NAMEs: GINSBERG, CHARLES ;HOH, CARL K (contact);VERA, DAVID R.

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: Adverse event;Albuminuria;Binding;Biodistribution;Biological Markers;Bladder;Blood;Cell Physiology;Cell surface;chemical safety;Chronic Kidney Failure;Clinical;clinical trial protocol;Clinical Trials;Clinical Trials Design;Creatinine;Data;db/db mouse;design;Development;Diabetes Mellitus;diabetic;Diabetic mouse;Diabetic Nephropathy;diabetic patient;Diagnosis;Diagnostic;Diagnostic tests;Discipline of Nuclear Medicine;Disease;disease model;Dose;drug development;Drug Kinetics;Early Diagnosis;Early treatment;Effective Renal Plasma Flow;European;Evaluation;first-in-human;Future;glomerular filtration;Glomerular Filtration Rate;Glomerular Mesangial Cell;Half-Life;Heart;Hepatocyte;high risk;Histologic;Human;Hypertension;Image;imaging agent;imaging biomarker;Individual;International;Intervention Trial;Intravenous;Journals;Kidney;kidney cortex;Kidney Diseases;kidney imaging;kidney medulla;Kinetics;Laboratories;Laboratory Study;Liver;Macrophage;mesangial cell;microPET;Molecular;molecular imaging;Motivation;nuclear imaging;open label;Pathology;Patients;Periodicals;Persons;Phase I Clinical Trials;phase I trial;Plasma;Positron-Emission Tomography;Prevalence;Protocols documentation;Publishing;radiation absorbed dose;Radiolabeled;Radiopharmaceuticals;Rattus;Renal Hypertension;research clinical testing;Risk;Safety;safety assessment;Sampling;Scanning;Serum;single photon emission computed tomography;Specificity;standard of care;Surface;Technetium 99m;Testing;Therapeutic Intervention;Time;tool;Urine

PROJECT_TITLE: Renal Molecular Imaging of Mesangial Cell Function with Tc-99m-Tilmanocept

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Mental Health;Mental Illness;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: Patients with neuropsychiatric disorders (attention deficit/hyperactivity disorder, substance use disorders, schizophrenia, bipolar disorder, Parkinson’s disease, post-traumatic stress disorder and depression among many others) often carry altered activity in the human dopamine transporter gene (hDAT). This proposal aims to identify molecular mechanisms by which regulated hDAT activity is altered, enabling our understanding of the genetic etiologies of the hDAT-related diseases. Our ultimate goal is to reveal pathogenic hDAT sequence variants and facilitate the development of precision treatment.

PI_NAMEs: LIN, ZHICHENG CARL (contact)

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: Affect;Alcohol consumption;Alleles;American;antagonist;Attention;Attention deficit hyperactivity disorder;Autopsy;Behavioral;Binding;Bipolar Disorder;Brain;Brain Diseases;Cells;cis acting element;Cocaine;cocaine self-administration;Cocaine use disorder;Cognition;Complementary DNA;Complex;Consensus;Cultured Cells;Development;Dinucleoside Phosphates;Disease;DNA Sequence;Dopamine;dopamine transporter;Dose;Endogenous Factors;Enhancers;Eukaryotic Initiation Factors;Exogenous Factors;Exons;experimental study;Gene Expression;Genes;Genetic Polymorphism;Genetic Predisposition to Disease;Genetic study;Genetic Transcription;Goals;Haplotypes;Hormones;Human;hybrid gene;In Vitro;in vivo;Individual;Introns;knockout gene;Knowledge;Lead;Locomotion;Mediating;Mental Depression;Midbrain structure;Minisatellite Repeats;Molecular;Molecular Genetics;Motivation;Mus;National Institute of Drug Abuse;neuropsychiatric disorder;neurotransmission;novel;Nuclear;Parkinson Disease;Pathogenicity;Patients;Plasmids;Play;Post-Traumatic Stress Disorders;Precision therapeutics;prevent;programs;promoter;protective factors;protein complex;Proteins;Regulation;Research;reuptake;Risk;Risk Factors;RNA;Role;Schizophrenia;Short-Term Memory;Side;Signal Pathway;Site;Source;spatiotemporal;Stress;substance use;Substance Use Disorder;Testing;Time;transcription factor;Transcription Initiation Site;Transcriptional Regulation;Transfection;transmission process;Untranslated Regions;Validation;Variant

PROJECT_TITLE: Human dopamine transporter gene: variation and transcriptional regulation

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative: The understanding of brain disease is profoundly impaired by the very primitive understanding of the brain as a system. The BRAIN Initiative ambition to produce a dynamic picture of the functioning brain by developing and applying improved methods for large-scale monitoring of neural activity was designed to address this deficiency. We address this objective for single cell resolved activity, increasing by 10-50X the number of resolved single unites in routine electrophysiology, compatible with freely moving mice or rats and many applications for primates.

PI_NAMEs: HARRIS, TIMOTHY D (contact)

PROGRAM_OFFICER_NAME: HWANG, GRACE MEI-HUA

PROJECT_TITLE: Neuropixels NXT: Integrated Silicon Probes for Large Scale Extracellular Recording in Rodents and Primates


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Depression;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Project Narrative  Opioid use disorder (OUD), a significant epidemic with comorbid depression, polysubstance use and neonatal abstinence syndrome, is currently treated with buprenorphine to reduce withdrawal, effects the social emotional brain circuits of that govern maternal caregiving thoughts and behaviors and influence infant development are unknown. This interdisciplinary project will employ multimodal and longitudinal brain imaging and measure parent-infant interactions to investigate how the maternal brain adapts to the early postpartum, focusing on the effects of buprenorphine with comparison groups of depression matched and healthy controls. The completion of this grant will yield brain-based biomarkers connected with inexpensive measures that will contribute to improved assessment and treatment of families suffering OUD, their children and society - which ultimately bears much of the cost for the common trans-generational problems of peripartum drug use.

PI_NAMEs: SWAIN, JAMES EDWARD (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: Adaptive Behaviors;Affect;Amygdaloid structure;Anxiety;Behavior;Behavioral;Biological Markers;Brain;brain based;brain behavior;Brain imaging;brain magnetic resonance imaging;Brain scan;Buprenorphine;buprenorphine treatment;caregiving;Caring;Child;Child Abuse and Neglect;child bearing;Child Rearing;clinical decision-making;Code;comorbid depression;comorbidity;comparison group;cost;Coupled;Crying;Data;design;Disinhibition;dosage;Dose;Drug usage;dyadic interaction;Emotional;Epidemic;Family;flexibility;foster care;Foundations;Globus Pallidus;Grant;gray matter;high risk;Hostility;Human;Hypothalamic structure;illicit opioid;imaging study;Impairment;improved;Infant;Infant Development;Insula of Reil;Interpersonal Relations;Intervention;Link;Magnetic Resonance Imaging;Maternal Behavior;maternal caregiving;Measures;Medial;Mediating;Mental Depression;Mental Health;Methods;midbrain central gray substance;Modeling;Mood Disorders;Moods;Mothers;MRI Scans;multimodal neuroimaging;multimodality;Neonatal Abstinence Syndrome;neural;Neurobiology;Nucleus Accumbens;offspring;Opiate Addiction;Opioid;opioid epidemic;opioid use;opioid use disorder;Outcome;Output;Parents;Participant;Perinatal;Physiology;polysubstance use;Postpartum Period;Postpartum Women;pre-clinical;Pre-Clinical Model;pre-clinical research;Pregnant Women;Preoptic Areas;prevent;Questionnaires;recruit;Research;Resolution;response;Rest;Risk;Severities;social;Societies;structural imaging;Thinking;translational potential;Ventral Tegmental Area;Withdrawal;Withdrawal Symptom;Woman;Work

PROJECT_TITLE: Opioids and Maternal Brain-Behavior Adaptation During the Early Postpartum

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Brain Disorders;Cardiovascular;Cerebrovascular;Comparative Effectiveness Research;Heart Disease;Hematology;Neurosciences;Patient Safety;Precision Medicine;Prevention;Stroke

ORG_CITY: DALLAS

ORG_DEPT: NEUROLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: The proposed research will develop patient-centered evidence-based anticoagulant therapy for secondary pre- vention in older ischemic stroke patients with atrial fibrillation. It is relevant to public health because the devel- opment and adoption of personalized evidence-based anticoagulant therapy are expected to reduce recurrent ischemic events, minimize treatment complications, and improve outcomes most meaningful to patients. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to developing fundamental knowledge that will help to enhance health and reduce the burdens of illness and disability.

PI_NAMEs: XIAN, YING  (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Address;Adoption;Age;Aging;American;American Heart Association;Anticoagulant therapy;Anticoagulants;Anticoagulation;Atrial Fibrillation;Benefits and Risks;burden of illness;Cardiology;Cardiovascular Diseases;Characteristics;Clinical;Clinical effectiveness;clinical practice;Clinical Trials;clinically relevant;college;Community Practice;comorbidity;comparative effectiveness analysis;Comparative Effectiveness Research;Complex;Creatinine;Data;Databases;Development;disability;Dose;Drug Kinetics;Effectiveness;effectiveness outcome;Embolism;Ensure;Equilibrium;ethnic minority;Event;evidence base;Evidence based treatment;Goals;Guidelines;head-to-head comparison;Health;Hemorrhage;Heterogeneity;high risk;Hospitals;human old age (65+);improved;improved outcome;Individual;individual patient;individualized medicine;innovation;Inpatients;Ischemia;Ischemic Stroke;Knowledge;Level of Evidence;Life;Link;Machine Learning;Medicare;medication compliance;Methods;Mission;Modeling;novel;Observational Study;Oral;Outcome;Overdose;patient oriented;Patient risk;Patients;Pattern;personalized medicine;Pharmaceutical Preparations;Population;Practice Guidelines;preference;Prevalence;prevent;Primary Prevention;Probability;Public Health;Publications;Quality of Care;racial minority;Recommendation;Recording of previous events;Recurrence;Registries;relative effectiveness;Renal clearance function;Renal function;Research;Risk;Risk Factors;risk/benefit ratio;Safety;safety outcomes;Sampling;Schedule;Secondary Prevention;Selection Bias;Selection for Treatments;Seminal;Severities;sex;shared decision making;Societies;Specific qualifier value;Stroke;stroke outcome;stroke patient;Stroke prevention;stroke survivor;Subgroup;Techniques;Testing;Therapeutic;therapy design;tool;Translations;treatment effect;United States;United States Centers for Medicare and Medicaid Services;United States National Institutes of Health;Warfarin

PROJECT_TITLE: Balancing Risks and Benefits of Direct Oral Anticoagulants in Older Ischemic Stroke Patients with Atrial Fibrillation


ADMINISTERING_IC: AR

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Social Determinants of Health;Women's Health Research

ORG_CITY: LEXINGTON

ORG_DEPT: OTHER CLINICAL SCIENCES

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative Anterior Cruciate Ligament reconstructions are a common procedure resulting in significant impairments in the quadriceps muscle, and females have worse outcomes than males. The identification of biological targets underlying poorer recovery in females after injury is lacking, limiting the development of evidence-based therapies. We propose to define the muscle molecular and cellular sex-based differences underlying poor functional recovery, the recovery of muscle function and gait mechanics, as well as determine the timing and magnitude of the psychosocial recovery differences between females and males to define sex as a biological variable across scales to mitigate these differences in recovery through novel interventions.

PI_NAMEs: FRY, CHRISTOPHER ;NOEHREN, BRIAN  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Acute;anterior cruciate ligament injury;anterior cruciate ligament reconstruction;Atrophic;Biofeedback;Biological;Biology;Biopsy;Biopsy Specimen;Blood capillaries;Capillarity;Caring;Clinical;clinical development;Clinical Practice Guideline;Clinical Trials;Clinical Trials Design;Combined Modality Therapy;Complement;Data;density;Development;endurance exercise;evidence base;exercise training;Exhibits;experience;Female;Fiber;follow-up;Foundations;functional decline;Functional disorder;Future;Gait;Gait abnormality;Gene set enrichment analysis;Growth;Hypertrophy;Immunohistochemistry;Impairment;improved;improved outcome;Injury;Intervention;Joints;Knee;Knee Injuries;Knee joint;knee mechanics;Knowledge;limb injury;Limb structure;male;Mechanics;Molecular;Molecular and Cellular Biology;Morphology;multidisciplinary;Muscle;Muscle Fibers;Muscle function;Muscle satellite cell;muscle strength;new therapeutic target;novel;novel therapeutic intervention;Operative Surgical Procedures;Orthopedic Surgery;Outcome;Pathway Analysis;Pathway interactions;Patient Outcomes Assessments;pharmacologic;Phenotype;Physical Function;Physical therapy;Positioning Attribute;Postoperative Care;Procedures;Protocols documentation;psychosocial;psychosocial outcome;quadriceps muscle;Recovery;Recovery of Function;Regenerative capacity;regenerative rehabilitation;Rehabilitation Outcome;Rehabilitation therapy;Reporting;resilience;response;response to injury;Self Efficacy;sex;sex as a biological variable;Sex Differences;Skeletal Muscle;statistics;Testing;therapeutic target;Time;transcriptome sequencing;vastus lateralis;women's outcomes;women's treatment;Work

PROJECT_TITLE: Sex-based Muscular Adaptations, Capillary dysfunction and functional decline impact Knee-related psychosocial outcomes after acute knee injury (SMACK)

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Aging

ORG_CITY: NEW YORK

ORG_NAME: AMERICAN FEDERATION FOR AGING RESEARCH

PHR: Project Narrative Substantial human capital investments by the National Institute on Aging (NIA) and private partners have led to a growing number of clinician-scientists in aging research from a diverse array of specialties and disciplines. The pipeline of early-stage and established investigators would benefit greatly from a national platform that will convey scientific and research knowledge, foster networking and collaboration, provide mentoring and career development support, and advance transdisciplinary research. The overall objective of the Clin-STAR Coordinating Center is to establish a robust, multi-faceted and highly-networked national platform that will organize activities and provide resources for the cultivation, connection, and synergy of clinician-scientists in aging research from disparate specialties across the US.

PI_NAMEs: GILL, THOMAS MICHAEL;VAN DER WILLIK, ODETTE  (contact);WALSTON, JEREMY D;YAFFE, KRISTINE

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Acceleration;Acute;Address;Advisory Committees;age related;Aging;aging population;Alzheimer's disease related dementia;American;Area;career;career development;Caring;Clinical;Collaborations;Committee Members;Communities;Databases;Discipline;Disparate;effectiveness evaluation;Ethnic Origin;Fostering;Foundations;Funding;Future;Geography;Geriatrics;Geroscience;Gills;Grant;health care disparity;human capital;improved;Infrastructure;innovation;Institution;Interest Group;Investigation;Investments;Knowledge;Leadership;Medical;medical specialties;meetings;member;Mentors;Mentorship;multiple chronic conditions;National Institute on Aging;novel;older adult;Older Population;Operative Surgical Procedures;organizational structure;Outcome;outreach;Patient-Centered Care;Persons;Privatization;programs;public-private partnership;Race;Records;Reporting;Research;Research Design;Research Personnel;Resource Development;Resources;sabbatical;Science;Scientist;sex;skills;social media;Source;synergism;Training;Underrepresented Minority;United States National Institutes of Health;Vision;Visit;Vulnerable Populations;web site;webinar

PROJECT_TITLE: Clin-STAR Coordinating Center


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The change of quality of life in autism spectrum disorders (ASD) individuals is primarily attributed to social deficits, which may be associated, or even triggered by, atypical sensory processing, specifically tactile hypersensitivity. However, this relationship has not been investigated extensively and could be best explained by looking at how mouse models of ASD maladaptively respond to social touch and how social touch is encoded in the brain of these ASD models. This project will utilize a novel head-fixed behavioral assay in mice to investigate when avoidance behaviors and aversive facial expressions to social touch first emerge in development and neural circuit disruptions in the primary somatosensory cortex and basolateral amygdala (S1- BLA) circuit that underly social touch deficits in mouse models of ASD.

PI_NAMEs: CHARI, TRISHALA  (contact)

PROGRAM_OFFICER_NAME: SURPRIS, MARIPIERRE PAYEN

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;Affective;Age;Air;Amygdaloid structure;Animal Model;Animals;Area;autism spectrum disorder;autistic children;Aversive Stimulus;avoidance behavior;Behavior;Behavior assessment;Behavioral;Behavioral Assay;behavioral response;Biological Assay;Brain;Brain region;Child;comparison control;Computer Vision Systems;critical period;Data;design;Development;Disease;disorder control;disorder subtype;Electrophysiology (science);Emotional;Environmental Risk Factor;Exhibits;experience;Eye;Facial Expression;Fragile X Syndrome;Functional disorder;Future;Genetic;genetic risk factor;Head;Human;Hypersensitivity;immune activation;Impairment;in vivo;Individual;individuals with autism spectrum disorder;Knowledge;Link;machine learning algorithm;maladaptive behavior;Measures;Microelectrodes;model of autism spectrum disorder;Modeling;Monitor;Motion;mouse model;Mus;neural;neural circuit;Neurodevelopmental Disorder;Neurons;novel;Perception;Polystyrenes;postnatal;pre-clinical;prevent;Problem behavior;Quality of life;repetitive behavior;Research;Resolution;Running;Sensory;sensory stimulus;Silicon;social;Social Behavior;Social Controls;social deficits;Social Interaction;social relationships;somatosensory;Somatosensory Cortex;Stimulus;System;Tactile;tactile stimulation;targeted treatment;Testing;Touch sensation;Vibrissae;Work

PROJECT_TITLE: Cortico-amydala circuit dysfunction underlying avoidance behaviors and aversive facial expressions to social touch in mouse models of autism


ORG_CITY: PROVIDENCE

ORG_NAME: PROVIDENCE VA  MEDICAL CENTER

ORG_STATE: RI

PHR: The proposed research is relevant to VHA’s mission to “honor America’s Veterans by providing exceptional healthcare that improves their health and well-being.” Post-acute skilled home health care is a vital service for older Veterans who are discharged from VA Medical Centers to their home in need of additional nursing or therapy support. However, little is known about the decisions that influence the selection of the payer for home care services (i.e., VA versus Medicare), the quality of community home health care provided, and how these factors influence Veterans’ experiences of receiving skilled HHC and their health outcomes. Therefore, it is important to leverage both VA and Medicare data to understand HHC financing, quality, and outcomes for Veterans who receive skilled home health care, as well as the experiences of VA clinicians and staff, home health agencies, and Veteran and caregivers’ who receive this service to both inform the delivery of skilled home health care and improve Veterans’ health and well-being.

PI_NAMEs: GRAVENSTEIN, STEFAN  (contact);JONES, CHRISTINE D

PROJECT_TERMS: Acute;Admission activity;adverse outcome;Affect;Area;care coordination;care systems;Caregivers;Characteristics;Collaborations;Communities;Community Healthcare;Complex;Contracts;cost;Data;Development;Discipline of Nursing;Effectiveness;Eligibility Determination;Enrollment;experience;Foundations;functional improvement;Funding;Geriatrics;Goals;Growth;Health;health care cost/financing;health care delivery;health care quality;health care referral;health care service;health care service utilization;Health Personnel;Health Policy;Healthcare;high risk;high risk population;Home;Home Care Services;Home Health Agency;hospital readmission;Hospitalization;Hospitals;Human Resources;improved;Independent Living;innovation;insight;Interview;Knowledge;Leadership;Long-Term Care;Marketing;Measures;Mediating;Medical center;Medicare;Methodology;Methods;Mission;Modeling;mortality;Nursing Homes;Outcome;Pathway interactions;patient home care;patient population;Pattern;Personal Satisfaction;Policies;primary outcome;Process;Provider;provider networks;Qualitative Research;Quality of Care;readmission rates;Recommendation;Research;Research Design;Research Methodology;Resources;Risk;service delivery;Services;Shapes;shared decision making;Site Visit;skills;Social Work;Source;stakeholder perspectives;Structure;Techniques;Testing;tool;Veterans;Work

PROJECT_TITLE: Post-Acute Home Health Care for Veterans: Examining Payer Source, Quality, and Outcomes

STUDY_SECTION_NAME: HSR-6 Aging, Recovery, and Workforce[HSR6]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Health Services;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety;Prevention;Primary Health Care

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: Most patients with cognitive impairment are diagnosed relatively late in the disease process, and about half of people living with dementia are undiagnosed. We have developed a low-cost tool called eRADAR (electronic health record Risk of Alzheimer's and Dementia Assessment Rule) that uses information in electronic health records to help identify patients with undiagnosed dementia. This study will determine whether a supported process of reaching out to patients with high eRADAR scores as part of primary care leads to earlier detection of dementia and improves patient care.

PI_NAMEs: BARNES, DEBORAH E.;DUBLIN, SASCHA  (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Academic Medical Centers;Algorithms;Alzheimer's disease risk;California;Caregivers;Clinic;Clinical;clinical care;Clinical Research;Communities;comparison intervention;cost;Data;Data Element;Dementia;dementia risk;design;Detection;Development;Diabetes Mellitus;Diagnosis;Disease;Early Diagnosis;Education;Electronic Health Record;electronic structure;Emergency department visit;Ethnic Origin;experience;Family;Family member;follow-up;formative assessment;Funding;Goals;Health Care Rationing;health care service utilization;Health Services Accessibility;Healthcare Systems;high risk;human old age (65+);Impaired cognition;improved;Inpatients;Integrated Delivery of Health Care;Intervention;Interview;Laboratories;Machine Learning;Measures;medication compliance;Mental Depression;neuroimaging;Newly Diagnosed;outreach;Participant;Patient Care;Patient Education;patient oriented;patient population;patient subsets;Patients;Pattern;Performance;Persons;Population Heterogeneity;Pragmatic clinical trial;pragmatic implementation;pragmatic trial;Predictive Value;preventive intervention;Primary Care;primary care clinic;primary care provider;primary outcome;Procedures;Process;Quality of Care;Quality of life;Race;Randomized;Randomized, Controlled Trials;Recommendation;Request for Applications;Research Design;Research Support;Retrospective Studies;Risk;Role;San Francisco;satisfaction;secondary outcome;Services;sex;Specificity;Stroke;Subgroup;Surveys;Symptoms;System;Testing;tool;Traumatic brain injury related dementia;treatment arm;treatment as usual;Underweight;Universities;usual care arm;Validation;Visit;Washington;Work

PROJECT_TITLE: Low-cost detection of dementia using electronic health records data: validation and testing of the eRADAR algorithm in a pragmatic, patient-centered trial.


ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE The ubiquitin-proteasome system (UPS) is a homeostatic pathway for the targeted degradation of unwanted or defective proteins in cells, and cancer cells are especially dependent on the UPS to maintain pathologic cell proliferation and survival. Therefore, the variety of proteins that comprise the UPS have become high priority targets for cancer drug development. The goal of my research is to harness computational design and iterative sequence optimization to generate potent, specific, and cell-permeable stapled peptides that target a distinct binding interface on UBE1, the most apical enzyme of the UPS, in order to suppress protein ubiquitination at its source and thereby reactivate apoptosis in treatment-resistant leukemia.

PI_NAMEs: ZEINA, CHRISTINA MARIE (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: adduct;Affinity;alpha helix;anti-cancer;Antibody Formation;Antineoplastic Agents;Apical;Apoptosis;Binding;Binding Sites;Biochemical;Biology;Bortezomib;cancer care;cancer cell;cancer therapy;Cell Proliferation;Cell Survival;Cells;Charge;Chemicals;Chemoresistance;Complex;Creativeness;Dana-Farber Cancer Institute;Degradation Pathway;Derivation procedure;design;Deuterium;Development;drug development;drug discovery;Drug resistance;efficacy testing;Enzymes;Genetic;Goals;Homeostasis;Human;Hydrogen;In Vitro;in vitro activity;in vivo;individualized medicine;inhibitor;innovation;knock-down;Laboratories;Lead;leukemia;Leukemic Cell;Libraries;Malignant Neoplasms;Mass Spectrum Analysis;Measures;medical schools;Molecular;Molecular Conformation;mouse model;multicatalytic endopeptidase complex;multidisciplinary;Multiple Myeloma;Mutagenesis;Mutation;mutation screening;N-terminal;novel;novel therapeutic intervention;Oncology;Organism;Pathologic;Pathway interactions;Peptide Hydrolases;Peptides;Permeability;pharmacologic;Pharmacology;phase I trial;Physicians;pointed protein;Polyubiquitin;Predisposition;Proteasome Inhibition;protein aminoacid sequence;Proteins;Proteome;proteotoxicity;prototype;Quality Control;Reporting;Research;Resistance;Scientist;Series;Shapes;small molecule;Source;stapled peptide;Stress;Structure;Surface;System;Technology;Testing;Therapeutic;thioester;Training Programs;treatment strategy;tumor;Ubiquitin;ubiquitin isopeptidase;Ubiquitination;uptake;Validation;X-Ray Crystallography

PROJECT_TITLE: Targeting the E1 Control Point of Protein Ubiquitination in Cancer


ORG_CITY: Decatur

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: GA

PHR: Photoreceptor dysfunction is one of the hallmark pathologies associated with retinal degenerative (RD) diseases that manifests in patients as a progressive loss of vision. This encompasses heterogenous diseases such as retinitis pigmentosa, which affects 1 in 3500 people worldwide and age-related macular degeneration, which is projected to affect 288 million people by 2040. We have shown modest exercise provides retinal neuroprotection in a mouse model of RD, through increased brain derived neurotrophic factor (BDNF) signaling. The cellular modifications provoking neural protection and repair from exercise are not understood. Our proposal reveals novel data supporting retinal astrocyte and vasculature involvement in exercise-induced BDNF signaling. Our studies will illuminate the roles of retinal astrocytes and vasculature in this known neuroprotective therapy, ultimately optimizing exercise-based therapeutics and creating new pharmacological strategies targeting the underlying mechanisms of exercise-induced neuroprotection.

PI_NAMEs: BALES, KATIE LEIGH (contact)

PROJECT_TERMS: Affect;Affinity;Age related macular degeneration;Animal Model;antagonist;Astrocytes;Atrophic;Award;Biological Assay;Biology;Blindness;Blood Vessels;Brain;Brain-Derived Neurotrophic Factor;Cell Density;Cell Separation;cell type;Cells;Cellular Morphology;Clinical Research;Clinical Trials;Computer software;Data;density;Disease;Disease Progression;Endothelial Cells;Exercise;exercise intervention;Exhibits;experimental group;Foundations;Functional disorder;functional improvement;Future;gain of function;Gene Expression;Gene Expression Profile;gene function;Goals;Healthcare;Hyperemia;Image;improved;In Vitro;Inbred BALB C Mice;Inflammation;Intervention;Knowledge;Label;Light;Light Exercise;Magnetism;Mediating;military veteran;Modeling;Modification;Molecular;Monitor;Morphology;mouse model;Mus;Nerve Degeneration;neural;neural repair;Neurodegenerative Disorders;neuroinflammation;Neuronal Plasticity;neuroprotection;Neurotrophic Tyrosine Kinase Receptor Type 2;neurovascular coupling;novel;Outcome Study;Pathogenesis;Pathology;patient population;Patients;Persons;Phagocytosis;pharmacologic;Phenotype;Photoreceptors;Physiological;preservation;Process;receptor;repaired;Research;response;Retina;Retinal Degeneration;Retinitis Pigmentosa;Retrospective Studies;Role;Severities;Severity of illness;Signal Transduction;Stress;Structure;Testing;Therapeutic;Translating;Up-Regulation;Vascular Endothelial Cell;Veterans;Vision;Visual impairment;Writing

PROJECT_TITLE: Investigating the role of retinal astrocytes in exercise-induced retinal neuroprotection


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: In addition to defects in DNA repair and fork protection, we have uncovered that cells deficient in the BRCA- pathway genes have defects in restraining DNA replication during stress and ssDNA regions (gaps) develop. Thus, we propose to employ state-of-the-art experiments to map the molecular determinants of this BRCA- pathway fork restraint function and identify the gap making and avoiding machinery that we find is critical for therapy response and resistance, respectively. Lastly, we will re-examine models of therapy resistance previously attributed to restored DNA repair and fork protection and determine if gap suppression is instead the fundamental resistance mechanism.

PI_NAMEs: CANTOR, SHARON B (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Ants;Biological Models;BRCA deficient;BRCA1 gene;BRCA2 gene;Breast Cancer gene;cancer cell;Cancer Patient;Cells;Chemoresistance;chemotherapy;Complex;Data Set;Defect;Degradation Pathway;Development;DNA;DNA biosynthesis;DNA Double Strand Break;DNA Repair;DNA replication fork;Double Strand Break Repair;effective therapy;experimental study;Filament;Functional disorder;Genes;Genome;Goals;Grant;Hereditary Breast Carcinoma;homologous recombination;Human Cell Line;Hypersensitivity;inhibitor;insight;Kinetics;Knowledge;Malignant Neoplasms;Maps;Measures;Mediating;Modeling;Molecular;Mutagens;mutant;Mutation;Outcome;Pathway interactions;patient response;Patients;Pharmaceutical Preparations;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;predictive marker;prevent;protective pathway;protein function;Proteins;Proteomics;Research;Resistance;Resistance development;resistance mechanism;response;restraint;Sampling;Single-Stranded DNA;Source;Stress;Testing;therapy resistant;tissue culture;treatment response;tumor;Tumor Markers

PROJECT_TITLE: Defining BRCA replication dysfunction in therapy response

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

PHR: Narrative We propose a multi-site, double-blind, randomized clinical trial of the 5-HT2A receptor agonist psilocybin for smoking cessation, based on pilot research suggesting potential for high rates of efficacy. The majority of individuals who try to quit smoking do not achieve long-term smoking abstinence with the medications that are currently available. Therefore, the proposed research will address a large unmet public health need to examine novel approaches for smoking cessation medications.

PI_NAMEs: JOHNSON, MATTHEW WAYNE (contact)

PROGRAM_OFFICER_NAME: MANDLER, RAUL N

PROJECT_TERMS: Abstinence;African American;Agonist;Alabama;Alcohol dependence;Biochemical;Cocaine Dependence;Cognitive;cognitive control;cognitive testing;Cognitive Therapy;comparative efficacy;Compensation;CXCL2 gene;Data;Death Rate;Disease;Double-Blind Method;effective therapy;efficacy testing;efficacy trial;ethnoracial;experience;FDA approved;follow-up;Funding;Grant;Hallucinogens;HTR2A gene;Human;improved;Individual;innovation;Intervention;Investments;Literature;long term abstinence;low socioeconomic status;Major Depressive Disorder;Marketing;Mediator;Medicine;Methods;New York;nicotine patch;Nicotinic Acids;Nonprofit Organizations;novel strategies;open label;Participant;Pharmaceutical Preparations;Phase;pilot trial;Placebos;Prevalence;Process;Psilocybin;psychologic;Public Health;Publishing;Randomized;randomized trial;randomized, clinical trials;recruit;Research;risk mitigation;Safety;Sampling;Sampling Studies;Serotonin Receptor 5-HT2A;Site;Smoking;smoking abstinence;smoking cessation;Smoking Cessation Intervention;Smoking Status;Socioeconomic Status;Testing;Therapeutic;Therapeutic Trials;Tobacco Use Disorder;treatment response;Universities;varenicline;Visit;Withdrawal

PROJECT_TITLE: 5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Medication Development Research Study Section[NIDA-L]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Immunization;Immunotherapy;Orphan Drug;Rare Diseases;Vaccine Related

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE We propose a first-in-human study that combines an adoptive cellular therapy modality, known as endogenous T cell (ETC) therapy with a therapeutic cancer vaccine (ISA103) targeting the broadly expressing PRAME tumor antigen. By boosting the in vivo frequency of the transferred T cells with a vaccine capable of directly activating PRAME -specific CTL and generating CD4 helper responses, we postulate that augmented persistence of transferred T cells and induction of antigen-spreading, will lead to more effective treatment for solid tumor malignancies and address the unmet clinical need of patients with uveal melanoma. It is anticipated that the results of this proof-of-concept study, developed through a robust scientific partnership between ISA Pharma and MD Anderson Cancer Center will allow us to broaden this triple T cell-based strategy to other patients and other tumor types.

PI_NAMEs: IKEGUCHI, ALEXANDRA P;YEE, CASSIAN  (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Address;Adoptive Cell Transfers;Adoptive Transfer;Adult;Alleles;anti-CTLA4;antigen-specific T cells;Antigens;Cancer Center;cancer infiltrating T cells;Cancer Vaccines;CD28 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Therapy;cell type;Cells;checkpoint therapy;chimeric antigen receptor;Clinical;clinical efficacy;clinical practice;Clinical Research;Clinical Trials;cohort;conditioning;conventional therapy;CTLA4 blockade;CTLA4 gene;Cutaneous Melanoma;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Development;Disease;Distant;Dose;effective therapy;Environment;Epigenetic Process;Epitope spreading;Epitopes;Event;Eye;Failure;first-in-human;Frequencies;Future;Genetic;human study;immune checkpoint blockade;Immune checkpoint inhibitor;immunogenic;Immunologics;Immunotherapy;In Vitro;in vivo;industry partner;Infusion procedures;Interleukin-2;kinase inhibitor;Liver;Malignant Neoplasms;Melanoma Vaccine;Memory;Modality;Modification;Mutation;Neoplasm Metastasis;novel;objective response rate;Patients;Peptides;peripheral blood;Phase;phase II trial;Population;preferentially expressed antigen in melanoma;Process;rational design;Refractory;Regimen;response;Safety;Series;Solid Neoplasm;Source;Specificity;standard care;success;Surface;T cell response;T cell therapy;T memory cell;T-Lymphocyte;Testing;Testis;Therapeutic;Time;tumor;Tumor Antigens;Tumor-Infiltrating Lymphocytes;Uveal Melanoma;Vaccination;Vaccines

PROJECT_TITLE: Immunotherapy of Uveal Melanoma using PRAME Vaccine in Combination with Adoptive T Cell Therapy

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Networking and Information Technology R&D (NITRD);Neurosciences;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation;Spinal Cord Injury;Telehealth;Traumatic Head and Spine Injury

ORG_CITY: PHILADELPHIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Project Narrative The lack of regular physical activity in over 290,000 individuals with spinal cord injury (SCI) in the US is an ongoing health crisis. The proposed study evaluates the integration of a just-in-time-adaptive intervention strategy with a web-based physical activity intervention program for individuals with SCI in the community.

PI_NAMEs: HIREMATH, SHIVAYOGI V (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: adaptive intervention;Address;Age;Algorithms;Behavior;behavior change;Behavioral;Cardiovascular Diseases;Clinical Trials;Clinical Trials Design;Communities;comparison intervention;Data;deconditioning;design;Diabetes Mellitus;Disabled Persons;Effectiveness;efficacy evaluation;Ethnic Origin;exercise intervention;exercise program;Fatigue;Feedback;Gender;General Population;Goals;Health;Health behavior;healthy lifestyle;improved;improved outcome;Individual;Injury;insight;Intervention;intervention program;Link;Lung Diseases;machine learning algorithm;Measures;Medical center;mHealth;mhealth interventions;Monitor;mortality risk;Movement;National Institute of Child Health and Human Development;novel;Online Systems;Outcome;Pain;Participant;Patient Self-Report;Persons;Physical activity;Physical assessment;Physical Exercise;physically handicapped;Physiological;pilot test;programs;Quality of life;Race;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;rehabilitation research;Reporting;Research;Research Personnel;sensor;Spinal cord injury;statistics;Subgroup;Technology;Testing;Time;treatment arm;trial design;United States;wearable device;Weight Gain;Wheelchairs;Work

PROJECT_TITLE: mHealth-based Just-In-Time Adaptive Intervention to Improve Physical Activity Levels of Individuals with Spinal Cord Injury

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Chronic Pain;Drug Abuse (NIDA only);Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

ORG_CITY: IRVINE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Opioid overdose has claimed the lives of over 450,000 adults in the United States since the turn of the century, an epidemic fueled in large part by physicians’ reliance upon opioids for chronic pain management. Successful mitigation of the opioid crisis is therefore dependent upon the identification of novel, non-opioid analgesics. By identifying key neural circuits involved in pain chronification, this project will pave the way for targeted, circuit- based therapies that effectively mitigate pain without the deleterious effects of long-term opioid use.

PI_NAMEs: HUI, MAY  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Acute;Acute Pain;Acute pain management;Adult;Affect;Amygdaloid structure;Analgesics;Animals;Area;Brain;Brain imaging;Brain region;Caring;cell type;Cells;Chromosome Mapping;chronic pain;chronic pain management;chronic pain patient;combat;Dependence;designer receptors exclusively activated by designer drugs;Development;Dose;Economic Burden;Elements;Epidemic;FOS gene;Functional disorder;Genetic;Genetic Recombination;Human;human imaging;Image;imaging modality;imaging study;Immediate-Early Genes;inhibitor;Injury;innovation;interest;Intervention;Investigation;Label;Light;Literature;Long-Term Effects;Maps;Mediating;Medical;Methods;Microscopy;Microspheres;Molecular Profiling;Mus;Negative Valence;neural;neural circuit;neuromechanism;Neurons;Nociception;non-opioid analgesic;Norepinephrine;novel;Operative Surgical Procedures;Opioid;opioid abuse;opioid epidemic;opioid misuse;opioid mortality;opioid overdose;opioid use;Pain;pain behavior;pain chronification;Pain management;Pain Map;Pain Measurement;pain sensitivity;Pathway interactions;Patients;Perioperative;Peripheral Nervous System;persistent symptom;pharmacologic;Physicians;Population;Positive Valence;premonitory sensory phenomena;prescription opioid;Presynaptic Terminals;Prevalence;prevent;Public Health;Rabies;rabies label;rabies viral tracing;Rabies virus;Resolution;reuptake;Rewards;Risk;sciatic nerve injury;Sensory;serial imaging;Serotonin;somatosensory;spatiotemporal;Spinal Cord;standard of care;Stimulus;Structure;Testing;Time;Tricyclic Antidepressive Agents;United States;Work

PROJECT_TITLE: Investigation of neural ensembles underlying chronic pain


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Palliative Care;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: PROJECT NARRATIVE Most patients and parents want to receive timely prognostic information, yet pediatric oncologists often delay or censor poor prognostic disclosure. Presently, the field of pediatric oncology lacks empiric data from stakeholders to characterize the optimal timing and process for patient/parent-centered prognostic disclosure and lacks a conceptual framework and clinical tools to encourage an individualized approach to prognostic communication across an advancing illness course. Under the guidance of my mentors, I will 1) characterize the preferences of patients, parents, and oncologists with respect to optimal content, timing, and delivery of prognostic disclosure, 2) partner with stakeholders to develop a framework and communication intervention, and 3) test the feasibility and acceptability of implementing this intervention to promote timely, individualized prognostic communication in the setting of advancing pediatric cancer.

PI_NAMEs: KAYE, ERICA CARMEN (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: acceptability and feasibility;advanced disease;Advanced Malignant Neoplasm;aged;anti-cancer research;arm;Award;Bereavement;cancer care;Cancer Patient;career;career development;Child;Child Care;Clinical;Clinical Investigator;Clinical Research;Clinical Trials Design;cognitive testing;cohort;Communication;communication behavior;Communication Research;Concept Formation;Data;Data Analyses;Decision Making;Dedications;design;Development Plans;Diagnosis;Disclosure;dissemination trial;Distress;Documentation;evidence base;Evolution;experience;Family;feasibility testing;Future;Goals;improved;Intervention;Intervention Studies;Interview;Investigation;K-Series Research Career Programs;Knowledge;Learning;Longitudinal Studies;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;member;Mentors;Mentorship;Methods;Oncologist;Palliative Care;parenting intervention;Parents;Patient Preferences;Patients;Pediatric Oncologist;Pediatric Oncology;Perception;personalized approach;phase 3 study;Phase I/II Trial;Pilot Projects;pilot test;Positioning Attribute;post intervention;preference;preservation;primary outcome;Process;Prognosis;prognostic;prognostication;programs;randomized trial;Randomized, Controlled Trials;Recommendation;Refractory;Reporting;Research;Research Personnel;Science;secondary outcome;Site;skills;stakeholder perspectives;Structure;Testing;Therapeutic;therapy design;Time;tool;Training;trial enrollment;usability;user centered design;Work

PROJECT_TITLE: IMPROVING PROGNOSTIC COMMUNICATION IN PEDIATRIC CANCER

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]