ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Genetic Testing;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Pediatric;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: Project Narrative People of African ancestry are vastly underrepresented in both: (i) clinical genetics research and (ii) human genetics reference panels (e.g. gnomAD), which makes them less likely to receive accurate genetic diagnoses. This work will leverage data from multiple large-scale efforts to improve medical genetic and diagnostic pipelines for people of African ancestry. The NeuroDev Kenya study provides the largest phenotypic characterization of rare genetic disorders in East African individuals to date and will help to identify rare genetic diagnoses in hundreds of East African individuals.

PI_NAMEs: O'DONNELL-LURIA, ANNE  (contact)

PROGRAM_OFFICER_NAME: KULCHAK RAHM, ALANNA LEE

PROJECT_TERMS: 22q11;Address;Affect;Africa;African;African American population;African ancestry;Age;aggregation database;Algorithms;Alleles;American;Atlases;Behavioral;Blood;Candidate Disease Gene;Child;Classification;clinical diagnostics;ClinVar;Cognitive;cohort;Communities;Constitution;Copy Number Polymorphism;Country;County;Data;Development;developmental disease;Diagnosis;Diagnostic;DiGeorge Syndrome;Discipline;Disease;disorder risk;DNA;Environmental Exposure;Ethnic Population;European ancestry;exome;expectation;Family;Frequencies;Funding;Gene Frequency;Genetic;genetic analysis;Genetic Databases;Genetic Diseases;genetic disorder diagnosis;Genetic Research;genetic resource;Genetic study;Genetic Variation;Genome;genome annotation;genome sequencing;genome-wide;Genomic medicine;Genomics;Hour;Human;Human Genetics;Human Genome;improved;in utero;Income;Individual;Kenya;malformation;Medical;Medical Genetics;Mendelian disorder;National Human Genome Research Institute;National Institute of Child Health and Human Development;Neurodevelopmental Disorder;Parents;Participant;Persons;Phenotype;phenotypic data;Population;Population Heterogeneity;postnatal;Probability;Psychoses;Rare Diseases;rare genetic disorder;Resources;Sampling;Syndrome;Testing;Variant;Work

PROJECT_TITLE: Improving Genetic Diagnosis for African Ancestry Populations

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: HS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: SAINT LOUIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ORTHOPEDICS

ORG_FIPS: US

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The purpose of this project is to transform an existing, university-based Long COVID clinic into a broader Long COVID community network in order to expand equitable access to care, improve the patient care experience, and support primary care practitioners in the St. Louis metropolitan area and surrounding rural region. Project activities will include: 1) refining care delivery through an existing multidisciplinary Long COVID clinic, and 2) supporting and collaborating with community primary care practitioners. Patient-centered care pathways and educational resources for practitioners will be co-developed with patient, clinician, and community stakeholders, and a continuous evaluation process will be used to iteratively adapt project initiatives to respond to the community’s evolving needs.

PI_NAMEs: CHENG, ABBY LING-LEE (contact);MARSCHALL, JONAS ;MCQUEEN, AMY

PROGRAM_OFFICER_NAME: ZHANG, XINZHI

PROJECT_TITLE: Advancing Long COVID Care in our Community through Access, Equity, and Collaboration


ADMINISTERING_IC: AA

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Health Services;Recovery Support Services;Rehabilitation;Social Determinants of Health;Substance Misuse

ORG_CITY: CLEMSON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: PROJECT NARRATIVE Alcohol use disorder (AUD) can lead to numerous health problems and medical complications that necessitate hospitalization, yet recovery care services for the underlying addiction are rarely offered to such patients during their hospital admission. To capitalize on hospitalization as a reachable moment for initiating recovery from AUD, the proposed research will test the cost-effectiveness and efficacy of the RC-Link program, a novel hospital- initiated long-term peer recovery coaching service, on recovery outcomes among inpatients (N=750) admitted for medical complications from AUD. Results from this research will inform us as to whether this intervention represents an evidence-based, individualized model of care for AUD that can readily be implemented in the hospital setting.

PI_NAMEs: BYRNE, KAILEIGH  (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: 2 arm randomized control trial;addiction;Address;Admission activity;Affect;alcohol comorbidity;Alcohol consumption;alcohol content;alcohol use disorder;Alcohol-Related Disorders;Alcoholic Gastritis;Alcohols;American;attributable mortality;biopsychosocial;brief intervention;care systems;Caring;Certification;Clinical Trials;community setting;comparison control;Control Groups;cost;Cost Analysis;cost effective;cost effectiveness;Cost Effectiveness Analysis;Cost Savings;Disease remission;dosage;Ecological momentary assessment;Effectiveness;effectiveness testing;Emergency department visit;Emergency Situation;Emotional;evidence base;Evidence based practice;flexibility;Frequencies;Health;Health Resources;Heavy Drinking;high risk;hospital readmission;hospital utilization;Hospitalization;Hospitals;improved;innovation;Inpatients;Intervention;intervention delivery;intervention program;Link;Lived experience;Liver diseases;long term recovery;Measures;Mediating;Medical;medical complication;Methods;Modeling;Morbidity - disease rate;Motivation;National Institute on Alcohol Abuse and Alcoholism;novel;Outcome;Pancreatitis;Participant;Pathway interactions;Patient Admission;Patients;peer;peer recovery;Persons;Pilot Projects;Population;post intervention;Prevalence;preventable death;Process;program costs;programs;psychosocial;Randomized, Controlled Trials;readmission rates;Recovery;recovery services;Recovery Support;Recurrence;reduced alcohol use;Rehabilitation therapy;Reporting;Research;Resources;Sample Size;Sampling;secondary outcome;Self Efficacy;Services;skill acquisition;social health determinants;Social support;Standardization;Substance Use Disorder;substance user;success;Testing;Time;treatment as usual;trial comparing;Visit;Work

PROJECT_TITLE: A Peer Recovery Coaching Intervention for Hospitalized Alcohol Use Disorder Patients

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Dissemination and Implementation Research;Immunization;Pediatric;Prevention;Primary Health Care;Vaccine Related

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE Hospitalized children are at high risk of being undervaccinated; this has important public health implications as undervaccinated children are at risk for acquiring and transmitting vaccine preventable diseases as seen in the recent measles outbreak in 2019. Currently, hospitalization is a missed opportunity to vaccinate with few children receiving any needed vaccines during hospitalization. This proposal will engage with nurses, pharmacists, physicians and parents to develop and test a technology-based intervention to identify undervaccinated children and improve vaccine delivery during hospitalization.

PI_NAMEs: BRYAN, MERSINE ALEXIS (contact)

PROGRAM_OFFICER_NAME: JENKINS, TAMMARA L

PROJECT_TERMS: Acceleration;acceptability and feasibility;Address;analytical method;Applications Grants;Award;care outcomes;career;career development;Child;Childhood;Clinical;clinical practice;Clinical Trials;Clinical Trials Design;Communication;Communication Research;Competence;Consolidated Framework for Implementation Research;contextual factors;Coupled;COVID-19 pandemic;Data;Dedications;design;Disease;Disease Outbreaks;Educational workshop;effectiveness-implementation randomized trial;Electronic Health Record;Eligibility Determination;Ensure;Evaluation;Evidence based intervention;Evidence based practice;Future;Goals;health communication;health information technology;Healthcare;high risk;Hospitalists;Hospitalization;Hospitalized Child;Hospitals;Immunization;implementation outcomes;implementation science;implementation strategy;improved;informant;Information Systems;innovative technologies;Inpatients;Intervention;intervention refinement;Interview;Maps;Measles;Mentors;Mentorship;Methods;Morbidity - disease rate;mortality;multidisciplinary;National Institute of Child Health and Human Development;Nurses;Parents;Pediatric Hospitals;Pediatric Research;Persons;Pharmacists;Phase;Physicians;pilot test;point of care;Population;population based;Primary Care;prototype;Public Health;public health priorities;Registries;Research;research and development;Research Personnel;Risk;Sampling;Site;skills;success;Surveys;technology intervention;Testing;therapy design;therapy development;Training;Translating;Translations;transmission process;United States Dept. of Health and Human Services;usability;user centered design;Vaccinated;Vaccination;vaccine access;vaccine delivery;vaccine hesitancy;Vaccines;Work

PROJECT_TITLE: Improving Vaccine Delivery in Hospitalized Children

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: NORTH CHARLESTON

ORG_NAME: EXPANSE BIO LLC

PHR: NARRATIVE Every year, thousands of potentially transplantable kidneys are not used and for every 5 waitlist patients who die, or become too sick for transplantation, 3 kidneys are discarded. Since quality of preservation/organ is linked to graft lifespan, with kidneys having only 50% graft survival after 10 years, extending kidney preservation to 7-9 days would address organ shortage by (a) enabling clinical immune tolerance induction, (b) greatly expanding options for donor-recipient matching and equitable allocation, (c) enhancing screening for transmissible diseases and malignancies, (d) decreasing costs and enabling flexible scheduling of surgeries, and (e) allowing for organ quality assessment and reconditioning. To address these needs, we develop a nature-inspired and machine perfusion enabled, subzero solution to dramatically extend preservation times of human and porcine (xeno) kidneys to (168-216h) 7-9 days, with thevalidation towards clinical application being accomplished with renal orthotopic autotransplantation in a porcine model, without and with “anywhere in the world” shipping, and complementary randomized physiologic ex-vivo assessment trial of 7-9 days stored human kidneys.

PI_NAMEs: BRANDACHER, GERALD ;TAYLOR, MICHAEL JOHN;WEEGMAN, BRADLEY P (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: 3-Dimensional;Achievement;Address;Animals;animation;authority;Autologous Transplantation;biomaterial compatibility;Clinical;clinical application;clinical practice;clinical translation;combinatorial;conditioning;cost;Country;Cryopreservation;design;Disease;Donor person;drug testing;efficacy testing;Equilibrium;Equity;experience;Family suidae;flexibility;gene therapy;Generations;Goals;graft function;Graft Rejection;Graft Survival;Healthcare Systems;high throughput screening;Human;Ice;Image;Imaging technology;Immune Tolerance;Immunosuppression;improved;Incidence;Inequity;Inferior;Kidney;kidney preservation;Kidney Transplantation;Lead;Letters;life span;Link;Liver;liver preservation;Living Donors;Logistics;Malignant Neoplasms;manufacture;Marketing;medication safety;Metabolic;metabolic depression;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;new technology;novel strategies;Operative Surgical Procedures;Organ;organ allocation;Organ Donations;Organ Donor;Organ Preservation;Organ Transplantation;Organ Viability;Oryctolagus cuniculus;Outcome;Patients;Perfusion;PF4 Gene;Pharmaceutical Preparations;Phase;phase change;Physiological;Play;porcine model;preconditioning;preservation;Protocols documentation;Randomized;Rattus;Recovery;Reperfusion Therapy;Research;Role;scale up;Schedule;screening;Shipping;Slice;stress tolerance;success;Surgeon;System;Techniques;Technology;Temperature;Thermodynamics;Time;Tissues;Toxic effect;transplant model;Transplant Recipients;Transplantation;Transportation;United Network for Organ Sharing;Validation;Waiting Lists;Xenograft procedure

PROJECT_TITLE: New approaches to kidney banking through nature-inspired high sub-zero preservation strategies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-R(11)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: CHICAGO

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Neurofibromatosis type 2 (NF2) is caused by loss of the tumor suppressor protein Merlin. Studies initiated using the fruit fly Drosophila and subsequently confirmed in mammals indicate that Merlin is part of a cellular mechanism, called the Hippo signaling pathway that regulates tissue growth during development. Our goal is to use the powerful genetic and cell biological tools available for Drosophila research to understand how Merlin functions to regulate the Hippo pathway so that we can understand what goes wrong in the NF2 disease, information which ultimately can be used to develop therapies to treat NF2 patients.

PI_NAMEs: FEHON, RICHARD G (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Actomyosin;Apical;Automobile Driving;bilateral vestibular Schwannoma;Binding;Biological;Caenorhabditis elegans;Cancer Biology;cell cortex;Cells;Complex;Cues;Curiosities;Cytoplasmic Protein;deafness;Development;Disease;disease phenotype;Drosophila genus;Epithelial Cells;Epithelium;Eukaryota;experimental study;extracellular;fascinate;Feedback;Funding;Genes;Genetic;Goals;Growth;Hepatocarcinogenesis;Human;human disease;insight;Intercellular Junctions;interest;Ligands;Malignant Neoplasms;Mammals;Mechanics;Medial;member;Membrane;meningioma;Modeling;Molecular;Morphogenesis;morphogens;Mutation;Natural regeneration;Neurilemmoma;Neurofibromatosis 2;Neurofibromin 2;novel;Oncogenic;Organism;Output;Pathway interactions;Patients;Pattern;Phosphotransferases;polarized cell;Process;protein activation;Proteins;recruit;Regulation;Research;Role;Scaffolding Protein;Signal Pathway;Signal Repression;Signal Transduction;Signal Transduction Pathway;Site;stem cell biology;System;targeted treatment;Techniques;Testing;therapy development;Tissues;tool;Transcription Coactivator;tumor;Tumor Suppression;Tumor Suppressor Proteins;ubiquitin-protein ligase;Work;Yeasts

PROJECT_TITLE: Function of NF2/Merlin in regulation of the Hippo/Salvador/Warts growth control pathway

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(02)M]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: FORT COLLINS

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: PROJECT NARRATIVE Family violence is a public health concern that threatens the health and well-being of women and infants, yet little is known about the mechanisms by which family violence influences women and infant outcomes during the perinatal period. The proposed research is relevant to NICHD’s mission because it will examine mechanisms of risk and resilience implicated in family violence, including biobehavioral and relational processes and individual differences in resiliency. This information will provide valuable information about modifiable factors that can be targeted to avert adverse health and developmental consequences among women and infants living in high-risk environments.

PI_NAMEs: BROWN, SAMANTHA M (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: 1 year old;Affect;Attenuated;Autonomic nervous system;Behavior;Behavioral;biobehavior;Biological;cardiometabolism;Characteristics;Child Abuse and Neglect;Child Health;cohort;Data;Development;Disproportionately impacts women;Emotional;Environment;ethnic diversity;Exposure to;Family;Family Violence;Fetal Development;First Pregnancy Trimester;Frequencies;Functional disorder;Generations;Health;health disparity;Heart Rate;high risk;Hydrocortisone;Hypothalamic structure;improved;Individual;Individual Differences;Infant;Infant Development;Infant Health;infant outcome;innovation;insight;intergenerational;Intervention;intimate partner violence;intrauterine environment;Life;Link;Longitudinal Studies;Low income;maltreatment;Maternal Health;maternal outcome;maternal stress;Mediating;Medical Records;Metabolic;Methods;Minority;minority children;Minority Women;Mission;Modeling;Mothers;National Institute of Child Health and Human Development;Outcome;Pathway interactions;Patient Self-Report;Pattern;perceived stress;Perinatal;perinatal development;perinatal period;Personal Satisfaction;Physiological;Physiology;Pituitary-Adrenal System;post pregnancy;postnatal period;postpartum outcome;Postpartum Period;Pregnancy;prenatal;Prevention strategy;Process;promote resilience;prospective;Prospective Studies;Public Health;racial diversity;Regulation;Research;resilience;resilience factor;response;Risk;Role;Second Pregnancy Trimester;Severities;social;Social support;stem;Stress;Stress and Coping;System;Third Pregnancy Trimester;Time;transmission process;violence exposure;Woman;women's outcomes;Work

PROJECT_TITLE: Mechanisms Linking Family Violence and Infant Health and Development in the Perinatal Period

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: GA

PHR: Project Narrative - Overall By reducing the risk-factors associated with foodborne illness and injury through implementation of a nationally integrated food safety system, we are helping to ensure food products manufactured, processed, packed, and held in Georgia; then distributed interstate, intrastate, and globally are safe and, by doing so, increase efforts to protect the public’s health. Our MFRPS-based regulatory program and the Georgia Food Safety and Defense Task Force rely on a partnership approach to advance the risk-based vision of an integrated system that better directs resources, minimizes duplication of efforts, and promotes prevention, intervention, and response. By focusing on a shared responsibility approach built on mutual reliance, we expect an outcome where food produced, processed, and distributed throughout Georgia, the U.S., and globally is part of an overall integrated, safer and healthier food supply where the occurrence of foodborne illness is minimized or eliminated altogether.

PI_NAMEs: NIELSEN, CRAIG  (contact)

PROGRAM_OFFICER_NAME: ARESHENKO, NICOLA

PROJECT_TITLE: Georgia Department of Agriculture (GDA) MFRPS Maintenance for Georgia's Manufactured Food Regulatory Program


ORG_CITY: Taylorsville

ORG_NAME: UTAH DEPARTMENT OF AGRICULTURE/FOOD

ORG_STATE: UT

PHR: RFA-FD-23-027 Infrastructure Development and Maintenance for the Utah Manufactured Food  Regulatory Program  Utah Department of Agriculture and Food OVERALL PROJECT NARRATIVE The overarching goals of the Utah Manufactured Food Regulatory Program for this three-year project are to continue to build on the capacity and infrastructure improvements that have been achieved during the past five-year grant period, and continue to build capacity to perform full- scope preventive controls and full-scope dietary supplement inspections under contract. 1

PI_NAMEs: WALLER, TRAVIS PINE (contact)

PROGRAM_OFFICER_NAME: RAMSEY, JOY

PROJECT_TITLE: Infrastructure Development and Maintenance for the Utah Manufactured Food Regulatory Program, UDAF


ORG_CITY: RALEIGH

ORG_NAME: NC STATE DEPT OF AGRI AND CONSUMER SERV

ORG_STATE: NC

PHR: Project Narrative – Overall The NCDA&CS Food and Drug Protection Division Food Program is submitting the enclosed proposal for funding to continue their efforts towards building the nationally integrated food safety system and maintaining conformance with the Manufactured Food Regulatory Program Standards (MFRPS). The outcomes that will be realized are the improvement of established Program infrastructure, development of new regulatory management practices and increased engagement in the North Carolina Food Protection Task Force. Successful implementation of these outcomes is critical to protect the public against foodborne illness.

PI_NAMEs: GAINES, DANIEL  (contact)

PROGRAM_OFFICER_NAME: D'ANGELO, JENNIFER

PROJECT_TITLE: Maintain conformance with current Manufactured Food Regulatory Programs Standards (MFRPS) and support a successful North Carolina Food Protection Task Force


ORG_CITY: LANSING

ORG_NAME: MICHIGAN STATE DEPT OF AGRICULTURE

ORG_STATE: MI

PHR: Project Narrative RFA-FD-23-027 The Flexible Funding Model (FFM) funding support will allow Michigan the opportunity to continue efforts to maintain a sustained approach to protect human health through food safety efforts. We have achieved and maintained full conformance and implementation with the most current version of the Manufactured Food Regulatory Program Standards (MFRPS). MFRPS will continue to be utilized to advance Michigan's efforts to be more consistent and uniform with federal and other state food regulatory programs, to establish a basis for measuring and improving performance, and to direct activities towards reducing food borne illness to further the nationally integrated food safety system.

PI_NAMEs: SLAWINSKI, TIM  (contact)

PROJECT_TITLE: MICHIGAN DEPARTMENT OF AGRICULTURE & RURAL DEVELOPMENT FFM-MFRPS MAINTENANCE & FOOD PROTECTION TASK FORCE MAINTENANCE


ORG_CITY: SAINT PAUL

ORG_NAME: MINNESOTA STATE DEPT OF AGRICULTURE

ORG_STATE: MN

PHR: Project Narrative The Minnesota Department of Agriculture (MDA) Food and Feed Safety Division (FFSD) seeks to maintain full conformance with the Manufactured Food Regulatory Program Standards (MFRPS) and promote continuos improvement of the standards along with maintaining a Minnesota Food Protection Task Force (FPTF) that provides a forum for all stakeholders of the state food protection system and maximize the protection of public health through integration activities. The MDA-FFSD will initiate a dietary supplement inspection program and complete special projects that support the Food and Drug Administration’s (FDA) mission and vision for building mutual reliance in an Integrated Food Safety System.

PI_NAMEs: OPSAHL, DAN  (contact)

PROJECT_TITLE: Expanding Minnesotas (MDA) Manufactured Food Program Efforts towards a Nationally Integrated Food Safety System and MFRPS Maintenance


ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Mount Sinai Health System has created a successful model of primary-care integrated care for Long COVID patients but it has limited reach into low-income communities of color hard hit by COVID-19. We propose a Long COVID specialty practice integrated in a Mount Sinai primary care practice in East Harlem that will engage socioeconomically disadvantaged patients through partnership with community-based service providers and deliver comprehensive, up to date, highly coordinated and patient-centered multidisciplinary Long COVID care. We will then extend access to this high quality care to more communities by equipping other primary care practices with the requisite tools, resources and training.

PI_NAMEs: FEDERMAN, ALEX D;WISNIVESKY, JUAN P (contact)

PROJECT_TITLE: Primary care-integrated Long COVID care to improve outcomes for minoritized adults in New York City


ORG_CITY: OLYMPIA

ORG_NAME: WA STATE DEPARTMENT OF AGRICULTURE

PHR: Flexible Funding Model- Infrastructure Development and Maintenance for State Manufactured Food Regulatory Programs (U2F) RFA-FD-23-027 Project Narrative This project intends to improve the nationally integrated human and animal food safety system through maintenance of the manufactured food regulatory program standards, food/feed Rapid Response Team, and Food Protection Task Force in Washington State. Through continued innovation, standardization, and collaboration between stakeholders both internal and external to the agency, the Washington State Department of Agriculture intends to work toward continually improved food safety and thus improved public health protection both within Washington State and nationally.

PI_NAMEs: NG, VIRGINIA  (contact)

PROGRAM_OFFICER_NAME: RAMOS, JOCELYN

PROJECT_TITLE: Flexible Funding Model Maintenance for Washington State Manufactured Food Regulatory Program 2023-2026


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Emergency Care;Firearms Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention;Rural Health;Social Determinants of Health;Violence Research

ORG_CITY: BALTIMORE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The proposed study will refine a feasible, comprehensive training strategy for improving the implementation of a universal trauma-center based firearm injury prevention program in Phase 1 and then study its implementation and effectiveness in Phase 2. Findings will establish a feasible, scalable framework for firearm injury prevention screening and counseling within trauma centers. Importantly, this research has the potential to impact clinical care, prevent firearm-related injury and death, and significantly contribute to implementation science for injury prevention initiatives.

PI_NAMEs: HOOPS, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: Address;Admission activity;Adopted;Adoption;Age;alcohol screening and brief intervention;American College of Surgeons;Attitude;brief intervention;Cause of Death;Cessation of life;Clinical;clinical care;clinical practice;Clinical Research;cohort;Collaborations;Community Hospitals;Competence;Counseling;Data;Education;Effectiveness;effectiveness testing;Electronic Health Record;Elements;firearm access;firearm storage;Firearms;follow-up;Foundations;Funding;Future;Goals;Gun injury;gun violence;Health Professional;Home;Homicide;Hospitals;implementation barriers;implementation research;implementation science;improved;injured;Injury;injury prevention;innovation;Institution;Intervention;Knowledge;Maintenance;Measures;Medicine;Methodology;Modeling;mortality;multi-site trial;multidisciplinary;Nurses;pandemic disease;Patients;Persons;Phase;post intervention;prevent;Prevention;Prevention approach;Prevention education;prevention practice;Prevention program;Prevention Research;Prevention strategy;preventive intervention;Program Development;programs;protective factors;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Recording of previous events;Research;Resources;Respondent;response;Rural;Rural Community;Rural Population;Safety;safety practice;Sampling;screening;screening, brief intervention, referral, and treatment;Site;Social Workers;suburban communities;Suburban Population;success;Suicide;Surveys;Time;Training;Training Programs;trauma centers;Trauma patient;Treatment Protocols;Urban Community;Urban Population;Violence;violence prevention

PROJECT_TITLE: ACTFAST: Urban and Rural Trauma Centers RE-AIM at Firearm Injury Prevention


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS STATE DEPT OF PUB HEALTH

ORG_STATE: MA

PHR: Project Narrative Through this cooperative agreement, the Massachusetts Department of Public Health, Bureau of Environmental Health/Food Protection Program will maintain conformance with the most current version of the Manufactured Food Regulatory Program Standards (MFRPS) and will support continuation of the of FDA Food Safety Inspection Contract No.: HHSF223201810018C. The Massachusetts MFRPS Program will continue to ensure and maintain best public health practices for a high-quality regulatory program to reduce foodborne illness hazards in plants that manufacture, process, pack, or hold foods. The Massachusetts Food Protection Program is committed to maintaining and improving its services via the incorporation of training, data sharing, data analysis, communications, and development of best practices and other resources to support national capacity/capability development.

PI_NAMEs: MOORE, MICHAEL J (contact)

PROJECT_TITLE: Flexible Funding Model-Infrastructure Maintenance for State Manufactured Food Regulatory Programs in Massachusetts


ORG_CITY: NASHVILLE

ORG_NAME: TN STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: TN

PHR: Maintain Tennessee's MFRPS Program in Conformance with Current Manufactured Food  Regulatory Program Standards  Project Narrative Tennessee recognizes the essential importance of a strong national Integrated Food Safety System. This project will allow TDA to leverage its existing manufactured food regulatory and inspection program’s strong framework to assist in the reduction of foodborne illness and hazards in plants that manufacture, process, pack, or hold foods. The proposed work in this application will provide TDA with a more robust manufactured food regulatory program, promoting a stronger Integrated Food Safety System.

PI_NAMEs: WITHERS, DANNY WAYNE (contact)


ORG_NAME: HUGO W. MOSER RES INST KENNEDY KRIEGER

PHR: PROJECT NARRATIVE Children, initially thought to be at lower risk for severe COVID-19, are not resistant to long COVID. Long COVID is a significant public health concern and can negatively impact the quality of life and functioning of children. Despite critical need for care of children with long COVID, patient volume far exceeds current capacity; thus, in this proposal we will expand services and capacity by identifying barriers, adapting our clinic to provide resources to mitigate these barriers, and educating primary care providers and community partners on the diagnosis, care, and management of children with long COVID.

PI_NAMEs: MALONE, LAURA A (contact)

PROJECT_TITLE: Mid-Atlantic Pediatric Long COVID Network:Implementing patient-centered and multi-disciplinary practices to improve pediatric long COVID


ORG_CITY: SAN ANTONIO

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE  The Comprehensive Long COVID Care for Underserved Communities: Innovative Delivery and Dissemination Models (COMUNIDAD) project is a 5-year program with 3 aims: 1) in collaboration with patient representatives, to expand and coordinate holistic, patient-centered multidisciplinary Long COVID care at UT Health San Antonio; 2) to disseminate information among clinicians in South Texas rural clinics on conducting a 15-minute, low-tech evaluation of patients presenting with Long COVID symptoms; and 3) to partner with community members in the largely Hispanic/Latino and rural South Texas region to increase health literacy and disseminate up-to-date information about Long COVID and access to Long COVID care.

PI_NAMEs: KILPELA, LISA ;TSEVAT, JOEL ;VERDUZCO-GUTIERREZ, MONICA  (contact)

PROJECT_TITLE: Comprehensive Long COVID Care for Underserved Communities: Innovative Delivery and Dissemination Models (Comunidad)


ORG_CITY: LITTLE ROCK

ORG_NAME: ARKANSAS STATE DEPARTMENT OF HEALTH

ORG_STATE: AR

PHR: Arkansas Department of Health's Wholesale/Manufactured Foods Maintenance for State Manufactured Foods Program &  Special Project Project Narrative The Arkansas Department of Health's (ADH) Wholesale/Manufactured Foods Program (WMFP) is submitting application for three years maintenance support of the Manufactured Food Regulatory Program Standards (MFRPS) and Special Project. The total amount of requested for the cooperative agreement is $697,988.23 dollars.

PI_NAMEs: FRUECHTING, PHILLIP  (contact)

PROJECT_TITLE: Arkansas Department of Health's Wholesale/Manufactured Foods Maintenance for State Manufactured Food Programs and Special Project


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Opioids;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human;Substance Misuse

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative Opioid and HIV infection are important public health problems. This proposal will generate information that will contribute to improved public health by providing a better understanding of the ways in which opioid exposure increases risks associated with HIV infection and spread.

PI_NAMEs: COLLINS, KATHLEEN L. (contact);WELCH, JOSHUA

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: Affect;Anti-viral Response;antiretroviral therapy;ATAC-seq;Atlases;Basic Science;Bioinformatics;Biology;Bone Marrow;Cell Differentiation process;Cell Line;cell type;Cells;Central Nervous System;Chromatin;Clinical Treatment;Complex;computer framework;cytokine;Detection;Diagnosis;Disease;Epigenetic Process;epigenome;epigenomics;Foundations;Future;Gene Expression;Genes;Goals;Hematopoietic;hematopoietic differentiation;Hematopoietic stem cells;Histone Deacetylase Inhibitor;histone modification;HIV;HIV Infections;Immune;Immune response;improved;Infection;Inflammatory;Innate Immune Response;insight;integration site;Joints;latent infection;Lipopolysaccharides;Macrophage;Maps;Measures;Mediating;Methods;Modeling;Molecular;monocyte;multiple omics;Myelogenous;new technology;novel;Opioid;opioid exposure;Opioid Receptor;pathogen;Pathogenesis;Pathway interactions;Peripheral;Peripheral Blood Mononuclear Cell;Phase;preference;Prevention;Public Health;receptor expression;Residual state;response;Risk;Role;single cell ATAC-seq;single cell sequencing;single cell technology;single-cell RNA sequencing;Site;Stimulus;substance use;Substance Use Disorder;Supporting Cell;T-Lymphocyte;Technology;Testing;Therapeutic;Time;Toll-like receptors;Transcriptional Regulation;transcriptome;transcriptomics;Viral;Viral Genes;Virion;Virus Activation;Virus Diseases;Virus Integration;Virus Latency;Work

PROJECT_TITLE: Single-cell multi-omic analysis of opioid-mediated HIV disease pathogenesis


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Prevention

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative We seek a UG3/UH3 to develop, implement and test the best care delivery model for an information technology enhanced bundled intervention to address strategies to end the HIV epidemic in multiple and diverse dental settings. This study builds upon our experience in HIV treatment and prevention, implementation science in both dental medicine, HIV and community based programs, behavioral science and bioinformatics.

PI_NAMEs: ALBERT, DAVID A;GORDON, PETER GREGORY;YIN, MICHAEL T (contact)

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: acceptability and feasibility;Accident and Emergency department;Address;Adoption;AIDS prevention;Ambulatory Care;antiretroviral therapy;Appointment;Attention;Attitude;Behavior;Behavioral Sciences;Bioinformatics;Caring;Clinic;Clinical;clinical decision support;clinically relevant;cluster randomized design;Communities;comparative effectiveness study;compare effectiveness;Computerized Medical Record;Crossover Design;dashboard;Dedications;Dental;Dental Assistants;Dental Care;Dental Clinics;Dental General Practice;Dental Hygienists;Dental Staff;dental structure;Dentists;Effectiveness;Electronic Health Record;Eligibility Determination;Enhancement Technology;Ensure;Environment;Epidemic;Evaluation;evidence base;experience;follow-up;Goals;Health;HIV;HIV risk;Hospitals;Human immunodeficiency virus test;implementation barriers;implementation evaluation;implementation process;implementation science;Incidence;Individual;Information Technology;innovation;Institution;Intervention;Knowledge;Link;longitudinal care;Maintenance;Measures;Medical;Medicine;Methods;Modeling;Neighborhoods;New York;New York City;Outcome;Patients;Performance;Persons;Phase;point of care;pre-exposure prophylaxis;preference;Presbyterian Church;Prevalence;Prevention;Process;programs;public health intervention;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;response;Risk Assessment;scale up;Self Administration;service delivery;Service delivery model;Services;Site;Specific qualifier value;success;support tools;Tablets;technology intervention;Testing;Time;tool;uptake;Variant

PROJECT_TITLE: Effectiveness of comprehensive ETE interventions in the dental setting


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Narrative Tumor associated myeloid cells within the tumor microenvironment play critical roles in suppressing adaptive immunity and stimulating tumor cell proliferation, invasion and survival. Our studies have shown that phosphatidylinositol-4,5-bisphosphate 3-kinase gamma (PI3Kg) and the pathways it controls drive lung cancer immune suppression; inhibitory targeting of this kinase stimulates anti-tumor immune responses that synergize with checkpoint inhibitors and chemotherapy. The overall goal of the proposed research is to delineate the mechanistic roles of PI3Kg in the regulation of lung tumor inflammation, growth and metastasis and to use these discoveries to develop novel therapeutic strategies to treat lung cancer.

PI_NAMEs: VARNER, JUDITH A (contact)

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: Accounting;adaptive immune response;adaptive immunity;Aftercare;Animal Cancer Model;antagonist;anti-tumor immune response;Antibodies;Antigen Presentation;Biochemical;Biological;Cancer Patient;Cell Physiology;Cell Proliferation;cell type;Cells;Cessation of life;checkpoint therapy;chemotherapy;Clinic;Clinical;Clinical Trials;Dendritic Cells;Disease;disease model;Disease-Free Survival;Dissection;Drug resistance;Early Diagnosis;Early treatment;Gene Expression Profile;Genetic;Genetic Transcription;Glioblastoma;Goals;granulocyte;Growth;Head and Neck Cancer;Human;human model;Immune;immune activation;Immune checkpoint inhibitor;Immune response;Immunooncology;Immunosuppression;improved;in vivo;Inflammation;Inflammatory;inhibitor;inhibitor therapy;innovation;insight;Invaded;Lung Carcinoma;Lung Neoplasms;Macrophage;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Melanoma;Modeling;Molecular;monocyte;mouse model;Mus;Myeloid Cells;Neoplasm Metastasis;neoplastic cell;neutrophil;new therapeutic target;Non-Small-Cell Lung Carcinoma;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Outcome;Pathway interactions;Patients;pharmacologic;Phase I Clinical Trials;phase II trial;Phenotype;Phosphatidylinositol 4,5-Diphosphate;Phosphotransferases;PIK3CG gene;Play;prevent;Property;Protein Isoforms;recruit;Regulation;Research;Resected;Resistance;resistance mechanism;Role;Signal Transduction;Solid Neoplasm;stemness;Survival Rate;synergism;T memory cell;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapy resistant;trafficking;tumor;Tumor Angiogenesis;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Tissue;Tumor-associated macrophages

PROJECT_TITLE: Role of PI3Kgamma in Tumor Progression and Metastasis

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: NEW ORLEANS

ORG_DEPT: CHEMISTRY

ORG_NAME: XAVIER UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Overall RCMI Narrative The RCMI Cancer and Health Disparities Research Center at Xavier University of Louisiana will build research capacity to support early stage, underrepresented investigators to conduct high- quality and impactful research on minority health and health disparities, especially in the area of cancer. The RCMI will be a multi-component center that includes a comprehensive research capacity core to provide the most needed data science and technology tools for Xavier investigators, an investigator development core to better prepare our early stage investigators for research success in competitive extramural support, particularly from NIH, and a community engagement core to promote research on minority health and health disparities and strengthen sustainable partnerships with community based programs in low income, minority neighborhoods.

PI_NAMEs: WANG, GUANGDI  (contact);WILLIAMS, CHRISTOPHER

PROGRAM_OFFICER_NAME: DAS, RINA

PROJECT_TERMS: Address;African American;anti-cancer research;Area;Basic Science;Behavior;Behavioral Research;Bioinformatics;Biological;Biomedical Research;Biometry;Cancer Center;cancer health disparity;career;career development;Clinical Research;Collaborations;Communities;community academic partnership;community engagement;Community Health;community involvement;community organizations;community research;Core Facility;Critiques;Data;Data Analyses;Data Science;design;Development;Drug Delivery Systems;Educational workshop;Evaluation;Extramural Activities;Faculty;Fostering;Funding;Grant;Health Disparities Research;health disparity;Health system;innovation;instrumentation;Intervention;Knowledge;Laboratories;Louisiana;Low income;Malignant Neoplasms;member;Mentors;Minority;minority health;minority health disparity;Minority Health Research;Modeling;Neighborhoods;Oncology;operation;Participant;Peer Review;Pilot Projects;Productivity;programs;Published Comment;Reduce health disparities;Research;research and development;Research Personnel;Research Priority;Research Project Grants;Research Proposals;Resources;service delivery;Services;skills;success;support network;symposium;System;Technology;Therapeutic Agents;tool;Training;Translating;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: RCMI Center for Cancer and Health Disparities Research


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: WANG, GUANGDI  (contact)

PROJECT_TERMS: Administrator;Advisory Committees;Applications Grants;Bioinformatics;Biomedical Research;Cancer Center;cancer health disparity;Common Data Element;Communication;community advisory board;Community Health;Contracts;Core Facility;Data Science;Dedications;design;Development;Environment;Evaluation;Extramural Activities;Faculty;faculty support;Funding;Funding Agency;Genes;Goals;Grant;Health Disparities Research;health disparity;Human Subject Research;IACUC;improved;Institution;Institutional Review Boards;interest;Leadership;Logistics;Louisiana;Measures;meetings;member;Mentors;minority health;minority health disparity;Minority Recruitment;operation;Outcome;Peer Review;Pilot Projects;Policies;Procedures;Process;Productivity;Program Evaluation;programs;Publications;recruit;Regulation;Reporting;Research;Research Activity;research faculty;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;satisfaction;Scientist;Secure;Services;Source;Structure;success;Surveys;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: RCMI Administrative Core


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Chronic Pain;Digestive Diseases;Interstitial Cystitis;Neurosciences;Pain Research;Urologic Diseases

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Narrative  The proposed studies will determine the role of pathologically enhanced signaling between sensory dorsal root ganglia (DRG) neurons and satellite glial cells in the development of pelvic pain and visceral cross- sensitization. These studies will reveal that gap junctions and the P2X7R-Panx1 functional complex drive the enhanced SGC-neuron intercellular signaling in this process, providing novel therapeutic targets for future clinical translation.

PI_NAMEs: SPRAY, DAVID C;SUADICANI, SYLVIA OTTILIE (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Afferent Neurons;allodynia;Animals;Attenuated;autocrine;behavior test;Behavioral;Biochemical;Bladder;Cells;cellular targeting;Chemicals;Chronic Disease;chronic pain;chronic pelvic pain;clinical translation;Colitis;Colon;colon distension;Colonic inflammation;Communication;comorbidity;Complex;Connexin 43;Coupling;Cyclophosphamide;cytokine;Development;Dinitrobenzenes;Disease;Dyes;Electrophysiology (science);Functional disorder;Future;Gap Junctions;glial activation;Hindlimb;Homeostasis;Hyperactivity;Hyperalgesia;Hypersensitivity;Image;Inflammasome;Inflammation;intercellular communication;Interstitial Cystitis;Irritable Bowel Syndrome;Label;Maintenance;Mediating;Mediator;Methods;Modeling;Molecular;Molecular Target;mouse model;Mus;neural;Neuroglia;neuronal excitability;Neurons;neurotransmission;new therapeutic target;novel;Organ;orofacial;Pain;pain chronification;pain model;Paper;Paracrine Communication;Pathologic;Pelvic Pain;Pelvis;Persons;pharmacologic;Play;Process;receptor;Reporting;response;Role;Sensory;Sensory Ganglia;Signal Transduction;Spinal Ganglia;Stains;Sulfonic Acids;Supporting Cell;Symptoms;Tactile;Testing;therapeutically effective;Tissues;Transgenic Mice;Visceral

PROJECT_TITLE: Role of neuron-satellite glia cell signaling in pelvic pain and visceral cross-sensitization


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Rural Health;Social Determinants of Health

PI_NAMEs: WILLIAMS, LAKEISHA  (contact)

PROJECT_TERMS: Address;anti-cancer research;aspirate;Cancer Center;cancer health disparity;Center for Translational Science Activities;Clinical Sciences;Collaborations;Communication;Communities;community academic partnership;community based participatory research;community engaged approach;community engagement;Community Health;community involvement;Community Networks;community organizations;Community Outreach;Consult;Decision Making;effective intervention;Ensure;Feedback;Fostering;Goals;Government;Health Disparities Research;health disparity;Health Professional;Health Promotion and Education;Health system;Infrastructure;innovation;Intervention;Knowledge;Leadership;Learning;Louisiana;member;Mentorship;Methods;Minority Groups;outreach;Participant;Population Study;Process;Recording of previous events;Research;Research Personnel;Research Project Grants;Resources;Risk;scientific organization;Services;Shapes;study population;success;Translating;Trust;vulnerable community

PROJECT_TITLE: RCMI Community Engagement Core


ORG_CITY: SACRAMENTO

ORG_NAME: CALIFORNIA STATE DEPT/FOOD/AGRICULTURE

PHR: Narrative The Milk and Dairy Food Safety Branch (MDFSB) of the California Department of Food and Agriculture (CDFA) is charged with the mission and responsibility of ensuring that California's milk, milk products, and products resembling milk products are safe and wholesome, meet microbial and compositional requirements and are properly labeled. To fulfill this mission, MDFSB conducts regulatory food safety activities at all sectors of the dairy industry from farm to table, including inspections of dairy farms, bulk milk tanker trucks, milk processing plants, industry milk testing laboratories and manufacturers of single-use dairy containers. MDFSB also collects regulatory samples of milk, milk products and water supplies for laboratory testing, responds to consumer complaints and food safety incidents, and initiates impounds and product recalls to protect public health as warranted. In addition, sanitation ratings by MDFSB personnel certify milk supplies and milk plants for U.S. Food and Drug Administration (FDA) approval to ship Grade-A milk and milk products in interstate commerce. MDFSB as part of the AHFSS Division of CDFA, relies on the ET database to manage daily business activities such as licensing, registration, certification, permitting, inspection, traceability, compliance, and enforcement. ET is also integrated with the California Animal Health and Food Safety (CAHFS) Laboratory System to electronically submit and receive testing results for dairy samples. A 2016 analysis of ET, performed by the California Department of Technology (CDT) Data Management Consultant, found that ET's current data model no longer represents the business need of AHFSS. The report also identified that the means to ensure reliable shared data, necessary for key management decisions, are not fully implemented, resulting in duplicate information and orphaned records (not linked to a parent record). The following data quality issues are just a few of the concerns identified in the CDT report: duplicate farm records (over 3,000); incomplete data (59,380 active operation records with no date); and invalid data issues (street number, street name, and street suffix are all in the same field and are not uniform, making it hard to search for existing premises). Since this report, these numbers have increased with the adoption of mobile devices to capture activity. Accurate information is essential to a rapid and effective response during an animal health or food safety incident and any delay increases the potentially negative effects and hinders control measures. The ET 2 database will help CDFA, including the Milk and Dairy Food Safety Branch, to respond efficiently and effectively to future food safety incidents, disease outbreaks, and natural disasters. This project is in accordance with the purpose of special projects outlined in the RFA to develop and implement special projects that support innovation and integration in a nationally Integrated Food Safety System (IFSS) using the MFRPS framework. This track will also support other emerging food safety priorities that develop over the lifespan of the project. CDFA is responsible for supporting the responsible jurisdiction and coordinating activities during and immediately following a disaster impacting the agriculture and food industry and supporting the recovery of impacted industries and resources post disaster. The plan specifically references AHFSS as a resource to protect public health, the health of California's livestock and poultry, and to provide safety of food at animal origin. This would include manufactured dairy products.

PI_NAMEs: BEAM, STEPHEN W (contact)

PROJECT_TITLE: California Milk and Dairy Food Safety Manufactured Food Regulatory Program Standards Maintenance and IT Development


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Long COVID impacts millions of people worldwide and has disproportionately impacted vulnerable populations such as communities of color and low-income persons. Comprehensive, coordinated, and person-centered care is needed for Long COVID patients but is difficult to access especially for these populations. The purpose of this project is to expand access to care for vulnerable patients with Long COVID through a partnership model that engages and empowers community primary care clinicians at federally-qualified healthcare centers to identify, care for, and refer patients with Long COVID with the support and collaboration of a multidisciplinary specialty team at an academic Long COVID center and community partners.

PI_NAMEs: BONILLA, HECTOR FABIO;GENG, LINDA N (contact);SINGH, UPINDER

PROJECT_TITLE: Long COVID Care Resources and Education to Advance Community Health (REACH)


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Childhood Obesity;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

PI_NAMEs: KNAPP, MEGAN  (contact)

PROJECT_TERMS: 17 year old;Address;Adopted;Adoption;Adult;Affect;Behavior;behavioral economics;Beverages;Black race;Calories;Cancer Center;cancer health disparity;Characteristics;Child;Cities;Collaborations;Communities;Consumption;Country;Data;design;Development;Diet;Effectiveness;Environment;Equity;Ethnic Origin;Evaluation;Fatty acid glycerol esters;follow-up;food environment;Fostering;Future;Goals;Health;Health Disparities Research;health disparity;health equity;health inequalities;Health Promotion;High Prevalence;high risk;Hispanic;implementation facilitation;implementation process;implementation science;improved;Income;Individual;Inequity;insight;Institution;Intake;Interdisciplinary Study;Interview;Juice;Laws;Location;Louisiana;Low income;Maintenance;Measures;Methodology;Milk;minority children;Minority-Serving Institution;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;nutrition;Obesity;obesity in children;obesity prevention;obesity risk;Outcome;Policies;Population;population based;Poverty;Practical Robust Implementation and Sustainability Model;Prevention;prospective;Quasi-experiment;Race;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Design;Research Personnel;Restaurants;Sampling;Site;Source;sugar;sweetened beverage;Time;Underrepresented Students;United States;Water;Work

PROJECT_TITLE: Evaluation of New Orleans Healthy Kids Beverage Menu Ordinance


ORG_CITY: CHARLESTON

ORG_NAME: WEST VIRGINIA STATE DEPT HLTH/HUMAN RSCS

ORG_STATE: WV

PHR: WV DHHR Manufactured Food Regulatory Program and Food Protection Task Force  Project Narrative In 2019 West Virginia Department of Health and Human Resources (WV DHHR), Oﬃce of Environmental Health Services received their ﬁrst full conformance audit for the Manufactured Food Program Standards. Since then, WV DHHR has held conformance through the hybrid audit performed in 2021 and conƟnues to work to maintain conformance with the new 2022 MFRPS. WV DHHR is invested in the Manufactured Food Program Standards because it allows us to maintain a program that puts a priority on protecƟng public health through evaluaƟng and monitoring risk, by maintaining inspecƟonal standards and training, and by sharing data with partners. WV DHHR is working to maintain and advance our framework for mutual reliance by ensuring our staﬀ are trained according to Standard 2. As an example, WV DHHR has one inspector fully qualiﬁed to conduct process controls inspecƟons, acidiﬁed inspecƟons, Juice HACCP, and low acid canned food inspecƟons, and plans to have a second trained in all these areas prior to the conclusion of 2025. WV DHHR works with FDA to conduct work planning for the FDA contract and shares noncontract state inspecƟon data with the FDA Liaison. Our standards require the program to assess areas of weakness and idenƟfy gaps in standards on a rouƟne basis and at a minimum annually. WV DHHR MFRPS Self-Assessment has idenƟﬁed areas for improvement in the past that resulted in working to add ﬁeld staﬀ to the manufactured food program speciﬁcally. It has idenƟﬁed areas that were weak regarding policy, like adding informaƟon about when samples could be released for validaƟon tesƟng and who could request their release. WV DHHR has also adopted 21 CFR 117 by reference as part of our Food Manufacturing FaciliƟes Rule W.Va. 64 CSR 43 in 2022. This change, along with modeling our standards based on the naƟonal program, helps reduce foodborne illness risks by allowing WV DHHR to focus on the hazards that cause illnesses during inspecƟons. WV DHHR has also maintained a Food ProtecƟon Task Force for as long as the organizaƟon has been enrolled in MFRPS and VNRFRPS. Our Task Force has maintained meeƟngs during the pandemic by meeƟng virtually and returned to hosƟng in-person in November of 2022. Moving forward the Task Force will host two in-person meeƟngs. One to set projects for educaƟon and goals speciﬁcally and the other will focus on updaƟng missions, vision, and governance. The Task Force will conƟnue to uƟlize virtual meeƟng space to conduct business between in-person meeƟngs for things like commiƩees and variance review. Our Task Force is instrumental in garnering input and feedback relaƟng to draŌing legislaƟon, creaƟng policies and procedures, providing guidance for variance reviews, and serving to communicate updates to consƟtuents and partner organizaƟons. The Task Force membership consists of local health department inspectors, state agency representaƟves (DHHR, Department of Agriculture, Department of EducaƟon), FDA, Food Manufacturers, Restaurants, Grocers, Academia, and ciƟzens.

PI_NAMEs: KING, DANIELLE  (contact)

PROJECT_TITLE: West Virginia DHHR Manufactured Food Regulatory Program and Food Protection Task Force


ORG_CITY: JEFFERSON CITY

ORG_NAME: MISSOURI STATE DEPT/ HEALTH & SENIOR SRV

ORG_STATE: MO

PHR: Project Narrative—Missouri FFM (Overall) This proposal for RFA-FD-23-027 is intended to improve food safety in Missouri and nationally. Through conforming to national standards and initiatives, the Missouri Department of Health and Senior Services’ food safety programs will apply the best practices necessary to integrate with other state and federal programs to reduce foodborne illness hazards at facilities under its regulatory jurisdiction.

PI_NAMEs: JENKERSON, MARK  (contact)

PROJECT_TITLE: Missouri Department of Health and Senior Services Flexible Funding Model


ORG_CITY: AUSTIN

ORG_NAME: TEXAS STATE DEPT OF HEALTH SERVICES

PHR: MFRPS MAINTENANCE - TASKFORCE COOPERATIVE AGREEMENT- TX DSHS – RFA-FD-23-019 This project will facilitate the Texas Department of State Health Services’ efforts to protect public health by reducing and preventing instances of foodborne illness and food contamination. Food safety procedures and practices will continue to be standardized and improved through shared innovation, effective assessments, coordinated response, mutual reliance, and relationship building with our local, state, and federal partners. The project supports the efforts of Texas to move to an integrated food safety system.

PI_NAMEs: KOEBRICK, DAVONNA  (contact)


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Social Determinants of Health

PI_NAMEs: HUCKABA, THOMAS M (contact)

PROJECT_TERMS: Active Sites;ALK gene;American;American Cancer Society;anaplastic lymphoma kinase;Binding;Binding Proteins;Biological Assay;Biological Availability;Caco-2 Cells;cancer cell;Cancer Center;cancer complication;cancer diagnosis;cancer health disparity;Cancer Relapse;Canis familiaris;Cell model;Cell Proliferation;Cellular Assay;Chimeric Proteins;Chromosomes;Clinic;Clinical;clinically relevant;Coiled-Coil Domain;Complex;Coupled;crizotinib;Cytochrome P450;Data;design;Development;Diagnosis;Dimerization;drug candidate;Drug Kinetics;Echinodermata;effective therapy;Effectiveness;Enzymes;FDA approved;flexibility;Generations;Genes;Health Disparities Research;in silico;In Vitro;in vitro Model;in vivo;inhibitor;interest;kinase inhibitor;Lead;Ligands;Malignant neoplasm of lung;Measurement;Mediating;Metabolic;Microtubule-Associated Proteins;Missense Mutation;Modeling;multicatalytic endopeptidase complex;Mutate;Mutation;Newly Diagnosed;Non-Small-Cell Lung Carcinoma;novel;Oncogenic;Oral;Outcome;Pathologic;Patients;Permeability;Pharmacodynamics;Pharmacologic Substance;Pharmacology;Phosphotransferases;Plasma Proteins;Point Mutation;pre-clinical;Process;Protac;Protein Kinase;Protein Tyrosine Kinase;Proteins;Publishing;Rattus;recruit;Relapse;relapse patients;Resistance;response;Safety;Series;small molecule;standard of care;Suppressor Mutations;Techniques;Testing;Therapeutic;therapeutically effective;treatment strategy;tumor;Tyrosine Kinase Domain;ubiquitin-protein ligase;Ubiquitination;Validation;Work;Xenograft procedure

PROJECT_TITLE: Developing a Selective PROTAC of Anaplastic Lymphoma Kinase for Treatment of ALK+ NSCLC


ORG_CITY: JUNEAU

ORG_NAME: ALASKA STATE DEPT/ENVIRONMTL CONSERVATN

ORG_STATE: AK

PHR: ALASKA DEPARTMENT OF ENVIRONMENTAL CONSERVATION PROJECT NARRATIVE: OVERALL COMPONENT Alaska's manufactured food regulatory program protects the safety of food manufactured in Alaska through inspections, education, intervention, compliance and enforcement tasks, research, collaboration, outreach, and the implementation of new or updated systems and technologies. Proposed projects fall into three areas of this funding opportunity: maintaining conformance with the Manufactured Food Regulatory Program Standards (MFRPS), growing partnerships through the Alaska Food Protection Task Force, and a special project to implement a new information management system. The projects detailed in this funding proposal are strategically situated to strengthen and support Alaska's manufactured food regulatory program in working with Alaskan facilities so that they manufacture food safely for consumers inside and outside of the state of Alaska.

PI_NAMEs: STRYKER, KIMBERLY  (contact)

PROJECT_TITLE: ADEC- FSS MFRPS Maintenance and Program Infrastructure Improvement


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Influenza;Networking and Information Technology R&D (NITRD);Pneumonia and Influenza;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Telehealth;Vaccine Related

PI_NAMEs: AL-DAHIR, SARA ABDUL SATTAR (contact)

PROJECT_TERMS: Address;African American;African American population;barrier to care;Beauty;Cancer Center;cancer health disparity;Clinical Trials Design;Communities;community based research;community engaged research;Continuing Education;Counseling;COVID-19;COVID-19 impact;COVID-19 risk;COVID-19 vaccination;COVID-19 vaccine;Data;digital medicine;digital technology;Discipline of Nursing;Disease;Disparity;Education;Educational Models;effectiveness evaluation;eligible participant;Employment;Essential worker;experience;Food;Food Services;Frontline worker;Goals;Grant;group intervention;Health;health care availability;Health Disparities Research;health disparity;health disparity populations;Health Professional;Health Services Accessibility;high risk;high risk population;Hospitals;improved;Individual;Industry;Influenza;influenza virus vaccine;innovation;Intake;Intervention;Literature;Louisiana;Measures;Medical;Medicine;minority communities;Minority Groups;Modeling;Outcome;outreach;pandemic disease;Participant;Pharmacists;Pharmacy facility;Plants;primary outcome;programs;Public Health;Qualifying;RADx Underserved Populations;Randomized;recruit;Research;Research Personnel;Research Project Grants;Resistance;respiratory;risk perception;Role;Rural;rural area;Rural Population;SARS-CoV-2 infection;secondary outcome;Series;social health determinants;Socioeconomic Status;Target Populations;telehealth;Testing;Training;Transportation;treatment group;treatment trial;Underrepresented Minority;underserved minority;Vaccination;vaccine acceptance;vaccine access;vaccine evaluation;vaccine hesitancy;Vaccines;Visit;vulnerable community;Woman;Workplace

PROJECT_TITLE: Using a Telehealth Model to Address Vaccine Hesitancy and Increase Vaccine Completion Among Communities in Southeastern Louisiana


ORG_CITY: HARRISBURG

ORG_NAME: PENNSYLVANIA DEPARTMENT OF AGRICULTURE

ORG_STATE: PA

PHR: MFRPS Maintenance Pennsylvania Department of Agriculture (PDA) With the continued support through the FFM grant, the Pennsylvania Department of Agriculture intends to continue and further develop the Manufactured Foods Program and implement a Food Safety Protection Taskforce in order to develop outreach materials with resources for academia, industry, and is committed to sharing these results and materials on a national level in order to foster and support an integrated food safety system. As a previous recipient of these grant awards, PDA has shown continued improvement of meeting grant deliverables and will continue to develop the programs implementing best practices, while participating in information sharing and mutual reliance to promote a national integrated food safety system.

PI_NAMEs: PYLE, SUZANNE  (contact);SMITH, STEFANIE M


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Long COVID has adversely impacted the health and emotional well-being of millions of people in U.S. communities. Access to Long COVID care can be limited and disconnected and often fails to address patient and family needs. The Atlanta Long COVID Collaborative leverages the city’s coordinated COVID-19 and Long COVID response, and brings together major academic and healthcare centers in the Atlanta metro area to improve person-centered care by expanding in-person and virtual visit options, adding care coordination staff, growing our multidisciplinary network and case conferences, expanding mental health services and group sessions, and engaging community support systems and patient advocacy groups to ensure Long COVID viewpoints are at the forefront of our patient-centered care delivery.

PI_NAMEs: HAN, JENNY ELIZABETH;TRUONG, ALEXANDER D.;WALKER, TIFFANY  (contact)

PROJECT_TITLE: The Atlanta Long COVID Collaborative: A Multi-Health System Long COVID Coordinated Care Model Serving a Diverse Metropolitan Population


PI_NAMEs: WIESE, THOMAS  (contact)

PROJECT_TERMS: Address;African American;Applications Grants;Area;Award;Cancer Center;cancer health disparity;career;Clinical;Collaborations;Data;data submission;Development;Disease;Disparity population;early-career faculty;experience;Extramural Activities;Faculty;Funding;Goals;Grant;Health Disparities Research;health disparity;health disparity populations;Link;Mentors;Minority;Participant;Peer Review;Pilot Projects;Process;programs;Publications;Research;research and development;Research Personnel;Research Project Grants;Resources;Scientist;success;Training;United States National Institutes of Health;Universities

PROJECT_TITLE: RCMI Investigator Development Core


ORG_CITY: FRANKFORT

ORG_NAME: KY ST CABINET/HEALTH/FAMILY SERVICES

ORG_STATE: KY

PHR: Kentucky Department for Public Health-Division of Public Health Protection & Safety  Food Safety Branch Flexible Funding Model-Infrastructure Development and Maintenance for State Manufactured Food Regulatory Programs (U2F) Clinical Trials Not Allowed (Funding Opportunity Announcement (FOA) Number RFA-FD-23-027). Project Narrative: The intended outcome of this Cooperative Agreement Funding Application for the 2023-2026 Period of Performance is to maintain and further advance efforts for a Nationally Integrated Food Safety System (IFSS) by utilizing available FDA funding assistance to allow The Kentucky Department for Public Health-Division of Public Health Protection and Safety-Food Safety Branch’s Manufactured Food Regulatory Program to maintain full conformance with the Manufactured Food Regulatory Program Standards (MFRPS). This funding will allow the MFRPS program to maintain current staffing levels (including a MFRPS Coordinator), recruit and retain a highly trained/qualified inspection team, review and update program SOPs, assist our federal (FDA) partners in establishing a uniform basis for measuring and improving the performance of manufactured food regulatory programs, and enhance our Regulatory Foundation to ensure that Kentucky’s Manufactured Food Regulatory Program develops and maintains best practices for a high-quality regulatory program. Kentucky’s continued with these program standards will help Federal and State programs better direct their regulatory activities at reducing foodborne illness hazards in plants that manufacture, process, pack, or hold foods.

PI_NAMEs: BELL, WILLIAM D (contact)

PROJECT_TITLE: Kentucky's Application for MFRPS, Dietary Supplements, Food Protection Task Force, and Special Projects


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: KOLESNICHENKO, VLADIMIR  (contact)

PROJECT_TERMS: Address;Area;Basic Science;Behavioral;Behavioral Research;Big Data Methods;Bioinformatics;Biomedical Research;Biometry;Cancer Center;cancer health disparity;Cellular biology;Charge;Clinical Research;Collaborations;Communities;computerized data processing;Core Facility;cost;Data Analyses;Data Analytics;Data Science Core;Data Scientist;Development;Drug Delivery Systems;drug discovery;Drug Formulations;Ecosystem;experience;Experimental Designs;experimental study;Faculty;Goals;Health;health data;Health Disparities Research;health disparity;health inequalities;improved;Institution;instrumentation;Investigation;Laboratories;Leadership;Maintenance;member;minority health;Molecular Biology;multiple omics;operation;Pilot Projects;Procedures;Production;Productivity;programs;Public Health Informatics;Recovery;Reduce health disparities;Research;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Resource Development;Resources;senior faculty;Services;social;Statistical Data Interpretation;statistics;System;Technical Expertise;Techniques;therapeutic development;tool

PROJECT_TITLE: RCMI Research Capacity Core


ORG_CITY: Aurora

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE: This project will create an integrated care network for Long COVID across the state of Colorado and implement a tiered-care delivery model bridging multidisciplinary and primary care for patients with Long COVID. The study will evaluate the impact of this care delivery model on Long COVID symptom burden and access to care.

PI_NAMEs: JOLLEY, SARAH E (contact);NEASE, DONALD E

PROJECT_TITLE: Novel Statewide Response to Post-COVID Care Delivery


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Prevention;Substance Misuse

ORG_DEPT: PHYSIOLOGY

ORG_NAME: LSU HEALTH SCIENCES CENTER

PHR: Project narrative Alcohol use decreases skeletal muscle strength and function. A clinical study among older people will investigate the effect of alcohol use on frailty risk, and the role of alcohol mediated muscle mitochondrial dysfunction as a contributing factor in chronological aging. The expected results will inform targets amenable to interventions to reduce risk, delay onset, or improve management of frailty.

PI_NAMEs: SIMON, LIZ  (contact)

PROGRAM_OFFICER_NAME: LIN, LI

PROJECT_TERMS: Activities of Daily Living;Address;Age;Aging;alcohol consequences;Alcohol consumption;alcohol effect;alcohol exposure;alcohol research;Alcoholic Liver Diseases;Alcohols;Area;binge drinking;Bioenergetics;Biological Markers;Biopsy;Caring;Chronology;Clinical Research;cohort;comorbidity;Cross-Sectional Studies;Data;Disease;Electron Transport;Equilibrium;frailty;Health;Health Care Costs;Heavy Drinking;High Prevalence;HIV;HIV Infections;Homeostasis;Impairment;improved;indexing;Individual;Infrastructure;insight;Intervention;Life Expectancy;Life Style;Link;Liver diseases;Longevity;Maintenance;Measures;Mediating;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Mitochondrial Proteins;Mobility decline;mortality;Muscle;muscle form;Muscle function;Muscle Mitochondria;muscle strength;Myoblasts;Myopathy;National Institute on Alcohol Abuse and Alcoholism;Nervous System Disorder;Older Population;Outcome;Pathology;Patient Self-Report;Persons;pharmacologic;Physical Performance;Physiological;Predisposition;prevent;Production;protein expression;Quality of life;reduced alcohol use;Reporting;Risk;Risk Factors;Risk Reduction;Role;Science;SIV;Skeletal Muscle;Strategic Planning;stressor;Syndrome;Testing;therapeutic target;United States;walking speed

PROJECT_TITLE: Alcohol and dysfunctional skeletal muscle mass: implications in aging


NIH_SPENDING_CATS: Behavioral and Social Science;Burden of Illness;Cancer;Cancer Genomics;Clinical Research;Comparative Effectiveness Research;Genetics;Health Services;Human Genome;Lung;Lung Cancer;Precision Medicine

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Personalized cancer treatment is becoming a reality with the real-world adoption of broad genomic profiling (BGP), which has enabled the simultaneous testing of hundreds of potentially targetable genetic alterations in patients with lethal cancer. The implications of BGP for cancer treatment, outcomes, and costs represent a substantial yet moving target in oncology that requires clinicians and policy makers to make decisions in the face of uncertainty. In this proposal, we address the critical need to understand real-world 1) BGP use and its impact on 2) clinical decision-making, 3) treatment outcomes and costs and 4) the value of additional research studies in uncertainty regarding BGP by leveraging the strengths of multiple complementary, real-world datasets.

PI_NAMEs: DINAN, MICHAELA ANN;GROSS, CARY P. (contact)

PROGRAM_OFFICER_NAME: FILIPSKI, KELLY

PROJECT_TERMS: actionable mutation;Address;Adoption;Advanced Malignant Neoplasm;Age;Blue Cross;Blue Shield;cancer care;cancer therapy;cancer type;care costs;Clinical;clinical decision-making;Clinical effectiveness;clinical practice;clinically relevant;comorbidity;Continuity of Patient Care;cost;cost effective;cost effectiveness;cost outcomes;Data Set;Decision Making;Decision Modeling;Diagnosis;Effectiveness;Epidermal Growth Factor Receptor;FDA approved;Fee-for-Service Plans;frailty;Frequencies;genetic testing;genomic profiling;Geography;Health;Histology;improved;innovation;Insurance;Insurance Coverage;KRAS2 gene;Label;large datasets;Malignant neoplasm of lung;Malignant Neoplasms;Medicare;Modeling;Mutation;Neighborhoods;Non-Small-Cell Lung Carcinoma;Oncology;Outcome;patient population;Patient-Focused Outcomes;Patients;personalized cancer therapy;Policies;Policy Maker;Population Study;Prevalence;Professional Organizations;Recommendation;Research;Research Personnel;research study;Smoking Status;Socioeconomic Status;Solid Neoplasm;targeted agent;targeted treatment;Testing;Time;timeline;Treatment Cost;Treatment outcome;treatment pattern;Uncertainty

PROJECT_TITLE: Broad Genomic Profiling in patients with advanced lung cancer: empirically assessing adoption, clinical utility, and the value of additional evidence in an evolving landscape of cancer care

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Cancer;Genetics;Orphan Drug;Precision Medicine;Rare Diseases;Urologic Diseases

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will transform our understanding of APOBEC3A-induced genetic intra-tumoral heterogeneity as a driver of targeted therapy resistance in bladder cancer. Successful completion of this project will 1- Identify targetable kinase hubs downstream of APOBEC3A-induced intra-tumoral heterogeneity to treat advanced bladder cancers that developed FGFR3 inhibitor resistance 2- Define novel synthetic lethal strategies to eliminate cancer cells with APOBEC3A activity. These advances will increase cure rates for patients with advanced bladder cancer.

PI_NAMEs: FALTAS, BISHOY MORRIS (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Bar Codes;biomarker identification;cancer cell;Cell Line;Cells;Cessation of life;Characteristics;clinical biomarkers;clinical risk;Clinical Trials;co-clinical trial;Cytidine;Cytidine Deaminase;Data;de novo mutation;Deamination;Decision Making;Development;Diagnosis;DNA Double Strand Break;Drug resistance;Evolution;Family;FGFR3 gene;Future;Genes;Genetic;Genetic Heterogeneity;Genetic Induction;Genomics;Goals;Human;improved;improved outcome;In Vitro;in vivo;Induced Mutation;inhibitor;innovation;insertion/deletion mutation;Knowledge;Laboratories;Malignant Epithelial Cell;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mediating;Mediator;Methods;Modeling;Mutagenesis;Mutation;novel;novel strategies;novel therapeutic intervention;Organoids;Pathway interactions;Patient-Focused Outcomes;Patients;pharmacologic;Phenotype;Phosphotransferases;Phylogenetic Analysis;Polymerase;precision medicine;pressure;prevent;Proto-Oncogene Proteins c-akt;Public Health;Publishing;refractory cancer;Relapse;repaired;Reporting;Research;Resistance;Resistance development;response biomarker;Role;Sampling;Signal Transduction;single-cell RNA sequencing;Specific qualifier value;standard of care;success;System;Systemic Therapy;targeted treatment;Testing;Therapeutic;therapeutically effective;therapy resistant;Transitional Cell Carcinoma;tumor;Tumor Bank;tumor heterogeneity;United States;Urothelium;Work;Xenograft procedure

PROJECT_TITLE: Targeting APOBEC3A-induced genetic heterogeneity and drug resistance in bladder cancer

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety;Pediatric;Physical Activity;Prevention

PHR: MoTrPAC Narrative While there are many important health benefits of physical activity, how exercise exerts its effects is not fully understood. A more comprehensive understanding of the molecular mechanisms underlying the responses to exercise would significantly impact public health. Continuation of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) will achieve its objective of generating a comprehensive map of the molecular responses to acute exercise and exercise training, with a long-range goal of elucidating the mechanisms by which exercise improves health.

PI_NAMEs: KOHRT, WENDY M (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: 17 year old;18 year old;Acceleration;Acute;Adipose tissue;Adult;Age;age group;aged;Ancillary Study;Animals;Attention;Award;Bioinformatics;Biological Process;Blood;California;Categories;Charge;Chemicals;Child;Childhood;Chronic;Clinical;clinical center;Clinical Protocols;Clinical Research;Clinical Trials Data Monitoring Committees;cohort;Collaborations;Collection;Colorado;Communication;Communities;comparison group;COVID-19;COVID-19 pandemic;Data;Development;Disease;Disease Outcome;endurance exercise;Enrollment;Ensure;ethnic minority;Ethnic Origin;Exercise;exercise intervention;exercise training;falls;follow-up;Frequencies;Funding;Gender;Goals;Health;Health Benefit;Heterogeneity;Human;improved;Individual;innovation;insight;Institutional Review Boards;Intervention;Manuals;Manuscripts;Maps;Measurement;men;Minority Groups;Molecular;Multi-site clinical study;multiple omics;Muscle;novel;Observational Study;operation;pandemic disease;Participant;Pathway interactions;Pediatric cohort;Phase;Phenotype;phenotypic data;Physical activity;Physiological;pre-clinical;Procedures;Protocols documentation;public database;Public Health;quality assurance;Race;racial minority;Randomized;Randomized, Controlled Trials;recruit;Recruitment Activity;Research;Research Personnel;resistance exercise;Resources;response;Rest;sedentary;sex;Site;Suspensions;Testing;Time;Tissues;Training;Transducers;United States National Institutes of Health;Universities;Visit;Woman;working group;Youth

PROJECT_TITLE: Molecular Transducers of Physical Activity Consortium - Colorado Clinical Center


NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: GALVESTON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: Persistent accumulation of DNA double-strand breaks (DSBs) in neuronal DNA is one of the early pathological features of Huntington’s disease (HD), a terminal neurodegenerative disease, suggesting that DSB repair is compromised in HD. We have discovered that huntingtin forms a specialized DNA repair complex, and that this novel complex maintains neuronal genome integrity and function. The proposed research will test whether there is a link between disruption of the activity of this complex and compromised neuronal genome integrity and neuronal gene expression in the presence of the mutant Huntingtin protein, which could inform strategies to target early processes to slow the progression of the disease.

PI_NAMEs: SARKAR, PARTHA S (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Age of Onset;Automobile Driving;brahma;Brain;CAG repeat;Cells;Central Nervous System;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Code;Complex;Coupled;Data;Development;Disease Progression;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Enzymes;DNA Single Strand Break;Double Strand Break Repair;Drosophila genus;Enzymes;functional restoration;Gene Expression;gene repair;Genes;Genetic Diseases;Genetic Transcription;Genome;genome integrity;genome wide association study;Goals;Health;Human;Huntington Disease;Huntington gene;Impairment;improved;in vivo;Individual;Induced pluripotent stem cell derived neurons;Knowledge;Link;Maintenance;Mediating;MJD1 protein;Modeling;Modification;Monitor;Motor;mouse model;MSH3 gene;Mus;mutant;Neurodegenerative Disorders;Neuroglia;Neuronal Differentiation;Neurons;Nonhomologous DNA End Joining;novel;Outcome;Pathogenesis;Pathologic;patient derived induced pluripotent stem cells;Patients;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Play;polyglutamine;Polynucleotide 5'-Hydroxyl-Kinase;Post-Translational Protein Processing;postmitotic;preclinical study;Process;protein complex;protein inhibitor of activated STAT 1;Proteins;Regulation;Repair Complex;Reporting;Research;response;RNA Polymerase II;Role;Severity of illness;Single Strand Break Repair;Site;Sumoylation Pathway;System;Testing;therapeutic target;Transcript;Transgenic Mice;ubiquitin-protein ligase;Work

PROJECT_TITLE: Regulation of HTT-mediated DNA damage repair and chromatin remodeling Complexes

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ORG_CITY: CARSON CITY

ORG_NAME: HEALTH AND HUMAN SERVICES, NEVADA DEPARTMENT OF

ORG_STATE: NV

PHR: State of Nevada Manufactured Regulatory Program Standards Maintenance 2024 RFA-FD-23-027 Project Narrative, Manufactured Food Regulatory Program Standards. This submission will continue to improve the MFRPS program. This form covers the overall project, a core project for Standards 1-10 and support for the Nevada Food Safety Task Force.

PI_NAMEs: HAYES, TERESA  (contact)


ORG_CITY: PHILADELPHIA

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: PROJECT NARRATIVE Over one third of patients treated in the emergency department (ED) are discharged without a definitive diagnosis, leaving patients with unaddressed fear regarding their symptoms and minimal assistance in their transition home from the ED. We developed tools to address uncertainty at the time of ED discharge in prior research and we now propose to leverage the electronic health record to implement a multifaceted strategy to facilitate higher quality discharge transitions for patients discharged from the ED with diagnostic uncertainty. Data on efficacy and implementation resulting from this trial will inform refinement of our implementation strategy as we work to disseminate the strategy widely with the goal of improving quality of care transitions for the one third of patients discharged from the ED with diagnostic uncertainty.

PI_NAMEs: MCCARTHY, DANIELLE M;RISING, KRISTIN LAURA (contact)

PROGRAM_OFFICER_NAME: COSBY, KAREN

PROJECT_TITLE: Targeted EHR-based Communication of Diagnostic Uncertainty (TECU) in the ED: An Effectiveness Implementation Trial


ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE Sepsis is a leading cause of death in children, and an early diagnosis that improves outcomes is less likely in children who are treated in general Emergency Departments (that treat adults and children) compared to pediatric Emergency Departments. In this study, we will adapt, implement, and evaluate tools that have improved diagnosis: a pediatric sepsis diagnostic checklist and diagnostic work system improvements to the consultation phone calls that occur among a general emergency physician, a transfer nurse, and a pediatric emergency physician. This research will improve early pediatric sepsis diagnosis in general EDs where most children receive their first critical hours of care, and it will identify approaches to improving diagnosis in that can be used in other high-risk conditions in emergency settings.

PI_NAMEs: SCOTT, HALDEN F (contact)

PROJECT_TITLE: The Right Call: Implementing a Sepsis Diagnostic Safety Toolkit in a Pediatric Transfer Call Center to Improve Diagnosis of Children in General Emergency Settings


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Long COVID encompasses a wide range of persistent symptoms and complications that impair quality of life and functioning of affected individuals with few disease-specific treatment options available, and evidence- based guidelines and comprehensive care models lacking. To address this need, we will partner with UPMC Family Medicine Academic Clinic Practice and the Black Equity Coalition (BEC) to establish the Pitt IMProving Access to Culturally relevant long COVID care and Treatment (IMPACCT) Program in order to train the next generation of community providers in long COVID care and improve access to both primary and specialty care for long COVID patients from minority and rural populations. We anticipate that our approach will lead to improved recognition, diagnosis, and management of long COVID, especially among underserved populations, as our proposal offers an innovative model to address health inequities and improve patient outcomes in our community and beyond.

PI_NAMEs: DEGENHOLTZ, HOWARD B;MORRIS, ALISON  (contact);SCIURBA, FRANK

PROGRAM_OFFICER_NAME: ZHANG, XINZHI

PROJECT_TITLE: The Pitt IMProving Access to Culturally relevant long COVID care and Treatment (IMPACCT) Program


ORG_CITY: ALBANY

ORG_NAME: NY STATE DEPT OF AGRICULTURE/ MARKETS

ORG_STATE: NY

PHR: Project Narrative: The New York State Department of Agriculture and Markets has a comprehensive food safety and inspection program. Support from FDA has enabled the Division of Food Safety and Inspection (FSI) to reach full implementation and conformance with all ten of FDA’s 2019 Manufactured Foods Regulatory Program Standards (MFRPS), and expand the capability of inspection staff, support training, provide additional staff resources to support the Standards, and improve systems for auditing, data capture, and reporting. Conformance with the MFRPS has placed the Department in a better position to share inspection information and data with FDA and other States, which will improve our response to, and help to prevent the incidence of food borne illnesses and food recalls.

PI_NAMEs: MCCARTHY, DAN  (contact)

PROGRAM_OFFICER_NAME: ARESHENKO, NICOLA

PROJECT_TITLE: MFRPS Maintenance NYSAGM


ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative The proposed project seeks to expand the existing UW multidisciplinary long COVID clinic (the Post COVID Rehabilitation and Recovery clinic) to improve access and coordination of care for patients with long COVID, particularly for underserved patients including patients in rural communities, Alaska, and in Latinx, Native American and SE Asian communities. We will also extend our community engagement and primary care training efforts across the WWAMI region to improve the care for patients with long COVID in a large geographic region with unmet needs.

PI_NAMEs: BENDER, JESSICA ANNE;FRIEDLY, JANNA L (contact);GENTILE, NIKKI

PROJECT_TITLE: Improving Access to Multidisciplinary Care for patients with long COVID


ORG_CITY: Trenton

ORG_NAME: NEW JERSEY STATE DEPT/HEALTH/SENIOR SRVS

ORG_STATE: NJ

PHR: PROJECT NARRATIVE  The New Jersey Department of Health, Public Health & Food Protection Program will continue to maintain conformance with the Manufactured Food Regulatory Program Standards (MFRPS) as we build capacity in our food safety program focused on public health, while working in collaboration with FDA and other stakeholders as part of an Integrated Food Safety System. The maintenance and continued implementation of the standards will provide the highest quality manufactured food inspection program as well as further enhancing food safety by quickly identifying foodborne illness and injury hazards.

PI_NAMEs: DETROIA, PETER J (contact)

PROJECT_TITLE: MFRPS Maintenance New Jersey Department of Health


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Neurosciences;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: NEW ORLEANS

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative Individuals diagnosed with attention deficit hyperactivity disorder (ADHD) are at a greater risk for developing an alcohol use disorder, especially if they initiate alcohol drinking during early adolescence. In this study, we will use a mouse genetic model of ADHD to determine if alcohol use during adolescence exacerbates ADHD-like symptoms using techniques to measure neural activity, alcohol self-administration, and cognition. The goal of this study is to better understand the specific neural mechanisms that promote excessive alcohol use in ADHD individuals and develop strategies to treat this unique and susceptible population.

PI_NAMEs: SALLING, MICHAEL CHARLES (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Acceleration;Addictive Behavior;Adolescence;Adolescent;adolescent alcohol exposure;adolescent binge drinking;Adult;Affect;Alcohol abuse;alcohol comorbidity;Alcohol consumption;alcohol exposure;alcohol risk;alcohol use disorder;alcohol use initiation;Alcohols;atomoxetine;Attention;Attention deficit hyperactivity disorder;Attenuated;Behavior;binge drinking;Brain;Cell Adhesion;Clinical Research;Cognition;cognitive control;cognitive performance;comorbidity;Data;density;Development;Diagnosis;Disparity population;Dopamine;Dopamine Agonists;drinking;early adolescence;Electrophysiology (science);endophenotype;Epidemiology;epidemiology study;experimental study;frontal lobe;G-Protein-Coupled Receptors;Genes;Genetic;genetic approach;genetic association;Genetic Models;Genetic study;Glutamates;Goals;gray matter;Haplotypes;Heavy Drinking;Heritability;High Prevalence;high risk;Human Genetics;Hyperactivity;Impaired cognition;improved;Impulsivity;inattention;Individual;Intervention;Knockout Mice;loss of function;Measurement;Measures;Mediating;Modeling;Morphology;Motivation;mouse genetics;Mus;Mutation;neural;neural circuit;Neurobiology;Neurodevelopmental Disorder;neuroimaging;neuromechanism;Neurons;neurotransmission;novel;Outcome;Pharmaceutical Preparations;Phenotype;Population;preclinical study;Predisposition;Prefrontal Cortex;Property;response;Rewards;Risk;Risk Factors;risk prediction;Rodent Model;Self Administration;Severities;Short-Term Memory;Symptoms;Synapses;Synaptic Transmission;Task Performances;Techniques;Testing;touchscreen;transmission process;underage drinking;Variant;Vertebral column;virus genetics

PROJECT_TITLE: ADHD and the influence of adolescent alcohol drinking on cognition and behavior

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Rare Diseases

PHR: We propose a new ribonucleoprotein (RNP)-gRNA CRISPR genome-editing strategy that will significantly increase efficiency of genome-editing clinical trials for neurogenetic diseases. We will specifically target two neurogenetic diseases with our RNP-based platform: Angelman Syndrome (AS) and H1-4 syndrome. Based on strong proof-of-concept and IND-enabling data and our extensive experience with clinical treatment and trials relating to these diseases, we propose a Phase 1/2a clinical trial to assess safety and tolerability in adults and children.

PI_NAMEs: BERRY-KRAVIS, ELIZABETH MARA;JIANG, YONG-HUI  (contact);ZHOU, JIANGBING

PROGRAM_OFFICER_NAME: BROOKS, PJ

PROJECT_TERMS: 17 year old;Acceleration;Adopted;Adult;adverse event monitoring;Angelman Syndrome;Animals;Anti-sense RNA;Antisense Oligonucleotides;Area;base editing;behavioral study;Biodistribution;Brain;C-terminal;cell type;Cells;Chemicals;Child;Chromosomes;Clinic;Clinical;clinical application;Clinical Treatment;Clinical Trials;Clinical Trials Design;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Complex;Contracts;cost;CRISPR/Cas technology;Custom;Data;derepression;design;Development;Disease;Dose;Drug Kinetics;effective intervention;Enrollment;Event;experience;Family;first-in-human;Foundations;Funding;Future;gain of function;gene delivery system;gene editing technology;gene repression;Genes;Genetic;Genetic Diseases;genome editing;genome editor;Genomics;Goals;Guide RNA;Human;Human Chromosomes;humanized mouse;immunogenicity;Impairment;imprint;improved;in vivo;Individual;Infrastructure;Intrathecal Injections;Investments;knock-down;Manuals;Mediating;Modeling;Modification;Molecular;Monkeys;mouse model;Mus;Mutate;neurobehavioral;Neurodevelopmental Disorder;neurogenetics;Neurologic;Neurons;novel;novel strategies;Organoids;Outcome Measure;patient derived induced pluripotent stem cells;Patient Recruitments;patient retention;Patients;pediatric patients;Penetration;Perinatal mortality demographics;Pharmacology and Toxicology;Pharmacology Study;Phase;phase 1 study;Phase I Clinical Trials;Phenotype;pre-clinical;pre-Investigational New Drug meeting;preclinical study;primary outcome;Production;programs;Proteins;Protocols documentation;Rahman Syndrome;rare genetic disorder;Regulatory Affairs;Research;response;Ribonucleoproteins;Rodent;Route;Safety;safety assessment;Signal Transduction;somatic cell gene editing;Structure;success;Surface;Syndrome;System;Tail;Technology;Therapeutic;Time;tool;Topoisomerase Inhibitors;Toxicology;trial design;UBE3A gene;United States National Institutes of Health;Universities;Untranslated RNA;Virus;Work

PROJECT_TITLE: A non-viral CRISPR-mediated genome editing delivery platform as a potential therapy for neurogenetic diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-M(70)R]