NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE Type1 Diabetes Mellitus (T1D) affects an estimated ~150,000 youth in the U.S., with ~18,000 youth diagnosed annually, yet much remains unknown about the clinical, developmental, and environmental effects of T1D on neurocognitive function. This proposal will establish a UNC clinical research center to participate in the T1D consortium to evaluate the neurocognitive complications of pediatric T1D and identify potential risks and protective factors that affect brain and cognitive development trajectories in children with a first-time diagnosis of T1D. The project will contribute to a multi-site clinical research infrastructure to recruit and retain children and families with T1D through stakeholder engagement and effective dissemination, and will develop predictive models integrating multimodal brain, behavior and clinical data to assist in risk stratification and development of effective targeted early interventions and clinical care practices.

PI_NAMEs: BELGER, AYSENIL  (contact);HWANG, JANICE JIN;JAIN, NINA

PROGRAM_OFFICER_NAME: WOO, THERESA TESLOVICH

PROJECT_TERMS: Academic achievement;Achievement;Address;Adult;adverse childhood events;Affect;Age;age effect;Anxiety;Attention;Automobile Driving;Behavior;Beta Cell;Biochemical;Biological;Biometry;Brain;caregiver stress;Caring;Cell Physiology;Child;Child Care;Childhood;Clinical;clinical care;clinical center;Clinical Data;Clinical Research;clinical research site;Clinical Services;Clinical Trials;Cognition;Cognitive;cognitive development;cognitive disability;cognitive function;Collaborations;Complex;Data;Defect;Development;Developmental Delay Disorders;diabetes education;Diabetes Mellitus;Diabetic Ketoacidosis;Diagnosis;Diagnostic;Dimensions;dissemination strategy;early childhood;Early Intervention;Education;Endocrinologist;Ensure;Equilibrium;evidence base;executive function;Exposure to;Family;Fingerprint;Functional disorder;Functional Magnetic Resonance Imaging;Future;health care availability;health care service;high risk;Hybrids;Hyperglycemia;Hypoglycemia;Image;Impaired cognition;Impairment;Individual;Infrastructure;Insulin Resistance;Insulin-Dependent Diabetes Mellitus;Intervention;Intervention Studies;Knowledge;Language;Learning;Link;Longitudinal Studies;low socioeconomic status;Maps;Measures;Memory;Mental Depression;Mental Health;Metabolic;Metabolism;Modeling;multidisciplinary;multimodality;Neurocognition;Neurocognitive;Neurocognitive Deficit;neuroimaging;Neurons;Newly Diagnosed;North Carolina;Observational Study;Outcome;Outcome Measure;Pathogenesis;patient population;Play;Population Heterogeneity;predictive modeling;prepuberty;prevent;protective factors;psychosocial;Psychosocial Stress;psychosocial stressors;Questionnaires;Race;recruit;Research Infrastructure;Residual state;resilience;resilience factor;response;retention rate;Risk;Risk Factors;risk prediction model;risk stratification;Role;rurality;Severities;sex;Site;social cognition;social health determinants;stressor;Structure;Support System;Symptoms;System;Technology;technology validation;Testing;Therapeutic Studies;Time;Vascular Diseases;Youth

PROJECT_TITLE: Mapping Neurocognitive Complications of Pediatric Type 1 Diabetes (T1D) and Potential Risk and Protective Factors

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-1 (M3)]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Sleep Research

ORG_CITY: NORFOLK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_FIPS: US

ORG_NAME: OLD DOMINION UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative While the role of sleep fragmentation (SF) in inflammation is an active area of investigation, impact of SF on promotion of vulnerable plaques is not well understood. This project will investigate NADPH-dependent mechanisms by which SF regulates plaque burden and test if restoring sleep leads to reduced atherogenesis.

PI_NAMEs: GALKINA, ELENA V (contact)

PROGRAM_OFFICER_NAME: KIRBY, RUTH

PROJECT_TERMS: Acceleration;Accounting;Adaptive Immune System;Adoptive Transfer;Affect;Age;Aging;aging process;Aorta;Apolipoprotein E;Apoptosis;Area;Arterial Fatty Streak;atherogenesis;Atherosclerosis;Automobile Driving;Blood;Cardiovascular Diseases;cardiovascular health;caregiving;Cause of Death;Cell Death;Cells;Cessation of life;Chronic Disease;chronic inflammatory disease;Circulation;Complex;Data;Development;Disease;DNA Damage;dysbiosis;Endothelial Cells;endothelial dysfunction;Epithelial Cells;Etiology;experimental study;Functional disorder;Gamma-H2AX;gut health;gut inflammation;Homing;Hypertension;Immune;Immune response;Immune system;Immunity;improved;in vitro Assay;Inflammasome;Inflammation;Inflammatory;Innate Immune System;intestinal epithelium;Intestinal permeability;Intestines;Investigation;LDL Cholesterol Lipoproteins;Leukocytes;Life;Life Style;Lipids;Macrophage;Measures;Mediating;Modeling;Modernization;modifiable risk;monocyte;Mus;Myeloid Cells;Myelopoiesis;NADP;NADPH Oxidase;Necrosis;neutrophil;Neutrophil Activation;Neutrophil Infiltration;Non-Insulin-Dependent Diabetes Mellitus;normal aging;old mice;Oxidative Stress;Oxidative Stress Induction;Pathway interactions;Persons;Phenotype;Play;Population;prevent;Process;Production;recruit;Regimen;Regulation;Reporting;response;restoration;Risk;Risk Factors;Role;Sleep;Sleep Apnea Syndromes;Sleep Deprivation;Sleep disturbances;Sleep Fragmentations;sleep quality;sleep quantity;stress granule;Structure;Testing;Vascular System;Work

PROJECT_TITLE: Disturbed sleep and atherosclerosis

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Stroke

ORG_CITY: NEW YORK

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Radon is a colorless, odorless, toxic radioactive gas and radon exposure is rising steadily within the modern North American residential environment. The proposed study aims to examine the association between radon exposure and stroke risk and to investigate whether the distribution of radon concentration is a reason for the racial and geographic variations of stroke rate in the US. Since randomized clinical trials on radon exposure is not feasible, findings from this study will provide crucial information to help identify a potential modifiable common risk factor for stroke.

PI_NAMEs: KAHE, KA  (contact);SMITH, BRIAN JOSEPH

PROGRAM_OFFICER_NAME: JETT, DAVID ALAN

PROJECT_TERMS: absorption;Adult;African American;African American Women;aged;Air;American;Ancillary Study;Area;Arteries;Biological Markers;Blood;Blood Pressure;Blood Vessels;Brain;burden of illness;C-reactive protein;Carcinogens;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Caucasians;Cause of Death;Child;Classification;cohort;Country;County;Data;design;Diet;disability;Disease;Environment;Environmental Risk Factor;Event;Exposure to;Factor VIII;Fibrin fragment D;Gases;General Population;geographic difference;Geographic Factor;Geography;Goals;Health;Health care facility;health care quality;Hemostatic Agents;Home;Hour;Household;Human;Hypertension;Individual;Infection;Inflammation;Inflammatory;Inhalation;insight;International Agency for Research on Cancer;Ischemic Stroke;Life Style;Link;Lipids;low socioeconomic status;Lung;male;Malignant neoplasm of lung;Measures;Metabolic Diseases;Minor;Modernization;modifiable risk;mortality;never smoker;Oxidative Stress Induction;Participant;particle;Pathologic;Pattern;Penetration;population based;Prevention;Publishing;Race;Radioactive;Radium;Radon;Random Allocation;randomized, clinical trials;Reactive Oxygen Species;Reasons for Geographic And Racial Differences in Stroke;Research;Resistance;Risk;Risk Factors;Smoking;Stream;Stroke;stroke risk;Time;Tissues;Tobacco smoking behavior;United States Environmental Protection Agency;Variant;Veins

PROJECT_TITLE: Residential Radon Exposure and Stroke Risk: the REGARDS Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(02)-M]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Diabetes;Neurosciences

ORG_CITY: HARTFORD

ORG_DEPT: CHEMISTRY

ORG_NAME: TRINITY COLLEGE

ORG_STATE: CT

PHR: PROJECT NARRATIVE ATP sensitive potassium channels (KATP) couple metabolic changes to changes in a cell’s electrical excitability, providing a crucial trigger for insulin secretion in response to elevated blood glucose and a protective response to ischemia in the heart. We have developed a combined spectroscopic and electrophysiological approach to study changes in the structure and function of KATP in response to metabolism. Understanding this process will illuminate KATP’s physiological role, provide mechanistic insight into diseases of KATP dysfunction (like neonatal diabetes), and serve as a template for understanding the structure/activity relationships of other protein complexes.

PI_NAMEs: PULJUNG, MICHAEL C (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Address;Adenine Nucleotides;Affinity;Amino Acids;ATP Hydrolysis;ATP phosphohydrolase;ATP sensitive potassium channel complex;Behavior;Binding;Binding Proteins;Binding Sites;Biochemistry;Biological;Blood Glucose;Cells;Cellular Metabolic Process;Color;Communication;Complex;Coupled;Couples;Coupling;Diabetes Mellitus;Disease;Electrophysiology (science);Enzymatic Biochemistry;experimental study;Fluorescence;Fluorescence Resonance Energy Transfer;Fluorescence Spectroscopy;Functional disorder;glucose uptake;Heart;Hydrolysis;Hypoxia;insight;insulin secretion;inward rectifier potassium channel;Ions;Ischemia;Ligand Binding;Link;Measurement;Measures;Membrane;Metabolic;Metabolism;Metals;Modeling;Molecular Conformation;Multienzyme Complexes;Multiprotein Complexes;mutant;Mutation;neonatal diabetes mellitus;Neurologic Deficit;novel;novel strategies;Nucleotides;Pancreas;Pharmacotherapy;Physiological;Play;Potassium Channel;Process;protein activation;protein complex;Protein Complex Subunit;protein function;Research;Resistance;response;Role;Signal Transduction;Site;Structure;Structure of beta Cell of islet;sulfonylurea receptor;Syndrome;Techniques;tool;Transition Elements;voltage clamp

PROJECT_TITLE: KATP: DYNAMICS OF A CHANNEL-ENZYME COMPLEX

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Single-cell sequencing of clinical specimens uniquely enables studies of tissue heterogeneity, a significant barrier to precision medicine. However, the use of single-cell assays for clinical decision making is limited. This project bridges that gap and develops algorithms to integrate heterogeneous single-cell datasets to support the selection of combination therapies.

PI_NAMEs: DIAZ, AARON ANTONIO (contact)

PROGRAM_OFFICER_NAME: FARRELL, CATHERINE MARY

PROJECT_TERMS: Adult Glioma;Algorithms;Anatomy;Antigen Targeting;Basic Science;Biological Models;Biopsy;Brain Neoplasms;California;cancer recurrence;Cell Line;Cells;Cellular Assay;chemotherapy;Childhood Brain Neoplasm;Chromatin;Clinic;Clinical;clinical care;clinical decision support;clinical decision-making;clinical sequencing;clinically actionable;clinically relevant;Code;cohort;combinatorial;Combined Modality Therapy;Complex;dashboard;Data;data dashboard;data integration;Data Set;Databases;Diagnosis;Disease;Disease Progression;DNA sequencing;Evolution;exome sequencing;Gene Expression;Genetic;Genomic approach;genomic predictors;genomic profiles;genotoxicity;Genotype;Glioblastoma;Glioma;Goals;Heterogeneity;Histology;human DNA sequencing;Image;immune cell infiltrate;improved;In Situ;in vivo;Informatics;Institution;Invaded;Ionizing radiation;Learning;Leukocytes;Link;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;Measurement;Measures;Medulloblastoma;Methodology;Methods;Modeling;Modernization;Monitor;Morphology;multiple omics;Mutation;neoantigens;Non-Malignant;novel;Organoids;Outcome;outcome prediction;Patients;Pharmaceutical Preparations;Phenotype;Phylogenetic Analysis;Phylogeny;precision medicine;precision oncology;Precision therapeutics;Prediction of Response to Therapy;Predictive Cancer Model;predictive modeling;Primary Neoplasm;Process;prognostic signature;Prospective cohort;Recommendation;Recurrence;Reporting;research clinical testing;Resistance;response;risk stratification;RNA;San Francisco;Selection for Treatments;simulation;single cell ATAC-seq;single cell sequencing;single-cell RNA sequencing;Site;Source;spatial integration;Specimen;statistics;System;T cell therapy;targeted treatment;Tissues;Training;training data;transcriptome sequencing;transcriptomics;Transposase;tumor;tumor heterogeneity;Universities;Validation;Visualization;Work;XCL1 gene

PROJECT_TITLE: An informatics framework for single-cell multi-omics from clinical specimens

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cervical Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: ARLINGTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF TEXAS ARLINGTON

ORG_STATE: TX

PHR: NARRATIVE Cervical Cancer prevention programs treat Black Women as a cultural and ethnic monolith. The proposed project uses a cross-sectional, mixed-methods design to: 1) identify the distinct determinants of routine cervical cancer screening and follow-up among Black African Immigrant Women and African American Women and 2) determine the intervention components that can be tailored to address the relevant multi-level factors influencing cervical cancer screening and follow-up among both populations.

PI_NAMEs: AMUTA, ANN OYARE (contact)

PROGRAM_OFFICER_NAME: SAMIMI, GOLI

PROJECT_TERMS: Address;Adherence;Affect;African;African American Women;American;Attitude;Awareness;Behavior;Behavioral;Belief;biopsychosocial;Black Populations;Black race;black women;Cancer Control;cancer health disparity;Cancer Intervention;cervical cancer prevention;Cervical Cancer Screening;clinical practice;Colposcopy;Communities;community based participatory approach;community collaboration;community engaged approach;Conscious;Country;Cultural Diversity;cultural values;Data;Death Rate;design;Development;Disease;Education;Educational Curriculum;Effectiveness;ethnic diversity;Ethnic Origin;evidence base;Evidence based intervention;experience;Focus Groups;follow-up;Frequencies;Goals;Health;health belief;health determinants;Health Professional;Immigrant;Incidence;Individual;informant;innovation;Intervention;intervention effect;intervention mapping;intervention refinement;Interview;Knowledge;Language;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Methods;migration;Minority;Modeling;mortality;National Cancer Institute;Outcome;Overweight;Phase;Population;preference;Prevention program;programs;Provider;Public Health Practice;Race;Race Relations;Registries;Religion;Reporting;Research Assistant;Research Personnel;screening;Screening for cancer;skin color;Slide;social;social culture;Socialization;Societies;Socioeconomic Factors;Spirituality;stem;Students;success;Summary Reports;Surveys;Target Populations;therapy design;United States;White Women;Woman;Women's Health;Work;Writing

PROJECT_TITLE: Development of Tailored, Multilevel Cervical Cancer Interventions for Ethnically Diverse Black Women

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Disability Research;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Rare Diseases;Rett Syndrome;Women's Health Research

ORG_CITY: FAYETTEVILLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE

ORG_STATE: AR

PHR: Project Narrative The signals sent from our brain to control our muscles require intricate interactions among large populations neurons in motor cortex and striatum. Recent advances in understanding population motor coding indicate the importance of high-dimensional geometric neural representations of body movement, but how these newly discovered motor coding mechanisms go wrong in brain disorders with motor dysfunction is unknown. The research proposed here would engage undergraduate researchers and reveal how high dimensional geometry of motor coding is disrupted in a transgenic animal model of Rett syndrome, a severe neurological disorder with prominent motor dysfunction.

PI_NAMEs: SHEW, WOODROW L. (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Accounting;Animal Model;Animals;arm movement;awake;Behavior;Behavioral;Body measure procedure;Brain;Brain Diseases;Brain region;Brain-Derived Neurotrophic Factor;Clinic;Code;cognitive disability;Color;Complex;Computers;Corpus striatum structure;Data;density;Dimensions;Elbow;Electrodes;Electrophysiology (science);Epilepsy;Etiology;Event;Exercise;experimental group;Face;frontier;Functional disorder;Future;gene function;Genes;Geometry;Goals;Grant;grasp;Grooming;Hand;Head;Health;high dimensionality;Hip region structure;Impaired cognition;improved;Knee;Knowledge;Left;loss of function mutation;machine vision;Measurement;Measures;Methyl-CpG-Binding Protein 2;Modeling;Monitor;Motility;Motor;Motor Cortex;Motor disability;motor disorder;motor impairment;Motor Skills;mouse model;Movement;Mus;Muscle;Nervous System Disorder;neural;neural circuit;Neurons;Neurosciences;Outcome;Persons;pharmacologic;Pharmacology;Physical therapy;Play;Population;Postdoctoral Fellow;Posture;Prevalence;Publications;rate of change;Research;Research Personnel;Resolution;Rett Syndrome;Rodent Model;Role;Running;Seizures;Severities;Shoulder;Signal Transduction;Speed;success;System;Tail;Techniques;Testing;theories;Transgenic Animals;Transgenic Mice;Translations;Treatment Efficacy;treatment strategy;undergraduate student;vigilance;Walking;Work

PROJECT_TITLE: High dimensional motor coding and motor dysfunction in Rett syndrome

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: SAINT LOUIS

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative  The proposed research will provide essential information to advance RNA research. The AI-ready data generated in this project can enhance the AI-driven approach for studying RNA structures, ultimately leading to a deeper understanding of the causes, diagnosis, prevention, and treatment of human diseases.

PI_NAMEs: HOU, JIE  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: 3-Dimensional;Address;Adopted;Algorithms;Artificial Intelligence;artificial intelligence algorithm;Artificial Intelligence enhanced;Collaborations;Communities;community engagement;Cryoelectron Microscopy;Data;Data Analyses;Data Set;data structure;deep learning;density;design;Development;Diagnosis;Education;education resources;educational atmosphere;Ensure;experience;Face;Future;Generations;Goals;Grant;human disease;improved;interactive visualization;interdisciplinary collaboration;Investigation;Learning;Length;Libraries;Machine Learning;machine learning algorithm;machine learning framework;machine learning method;machine learning pipeline;Maps;Methods;Mission;Modeling;Molecular Structure;National Institute of General Medical Sciences;novel;Nucleotides;open source;Preparation;Prevention;Process;programs;protein structure prediction;Pythons;Readiness;Research;Research Personnel;Resources;RNA;RNA Computations;RNA Folding;RNA Sequences;skills;Standardization;Structure;Students;Techniques;TensorFlow;three dimensional structure;three-dimensional modeling;Training;training data;undergraduate student;United States National Institutes of Health;Universities;user-friendly;Validation

PROJECT_TITLE: Improving Artificial Intelligence Readiness of RNA Motif Data for Structure Analysis and Modeling

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Infectious Diseases

ORG_CITY: FORT MYERS

ORG_DEPT: BIOLOGY

ORG_NAME: FLORIDA GULF COAST UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE Staphylococcus aureus is among the leading causative agents of both hospital and community acquired infections, it can survive in almost every facet of the human body, and poses a health risk for neonates and nursing mothers. Through student research, this project seeks to understand how this organism regulates virulence in conditions biologically relevant to in vivo infections.

PI_NAMEs: JAMES, KIMBERLY LASHUN  (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Acids;Aerobic;Affect;Alleles;Animals;Arginine;Bacterial Adhesins;Biomedical Research;Blood;Buffers;Cell surface;Cells;Community-Acquired Infections;Data;Deletion Mutation;differential expression;Environment;environmental change;Enzymes;experimental study;Fermentation;Future;Gene Expression;Gene Expression Regulation;gene product;Genes;Genus staphylococcus;Glucose;Goals;Growth;Health;Hemolysis;Hospitals;Human;Human body;Hypoxia;in vivo;Infection;Knowledge;Libraries;Link;Mediating;Metabolic;Metabolism;metabolomics;Microbial Biofilms;Modeling;Monitor;Mutagenesis;mutant;Mutation;mutation screening;Nebraska;neonate;nursing mothers;opportunistic pathogen;Organism;Outcome;Oxygen;Partial Pressure;Peptide Hydrolases;Peptides;Phenols;Phenotype;Physiological;Plasmids;Play;Production;programs;promoter;Publishing;quorum sensing;Regulation;Regulator Genes;Repression;Research;Research Personnel;Research Project Grants;respiratory;response;Risk;RNAIII;Signal Transduction;Site;Staphylococcus aureus;Students;System;Time;Tissues;Toxin;transcriptome sequencing;transcriptomics;undergraduate research;undergraduate research experience;Virulence;Virulence Factors;virulence gene;Work

PROJECT_TITLE: Investigating Cross-regulation of Staphylococcal Metabolism In The Agr Quorum Sensing System

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BOCA RATON

ORG_NAME: FLORIDA ATLANTIC UNIVERSITY

PHR: Repeated failures of A-reducing drugs provoke the reconsideration of APP’s function and disease relevance. Here, we will investigate APP mutations associated with inheritable Alzheimer’s disease in the context of neuronal cholesterol homeostasis. Supported by ample empirical and clinical evidence, this study will bring new insights about APP’s intrinsic function and pathogenic contribution, which will surely lead to new therapeutic treatment and preventative strategy.

PI_NAMEs: ZHANG, QI  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Adolescent;Affect;Age;Aging;Alzheimer's Disease;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein Precursor;amyloid peptide;Apolipoprotein E;apolipoprotein E-4;Apoptosis;Axon;axon growth;Biological;Brain;brain cell;C-terminal;Categories;Cell membrane;Cells;Cholesterol;Cholesterol Homeostasis;Chronic;Clinical;clinically relevant;CRISPR/Cas technology;Data;Dementia;Disease;disease phenotype;Early Onset Alzheimer Disease;Electrophysiology (science);Endocytosis;Environmental Risk Factor;Failure;familial Alzheimer disease;Functional disorder;Genes;Genetic;genetic risk factor;Genomics;Hand;Hippocampus;Homeostasis;Human;hyperphosphorylated tau;Imaging Device;induced pluripotent stem cell;Inherited;Innate Immune Response;insight;Investigation;Knock-out;Lead;Learning;Link;lipid metabolism;Lipoprotein Receptor;live cell imaging;Malignant Neoplasms;Measurement;Membrane;Memory;Mental Depression;Methodology;mouse model;Mus;mutant;Mutation;Nerve Degeneration;neural;neurodevelopment;Neuroglia;neuron loss;Neuronal Differentiation;Neurons;neurotransmission;novel therapeutic intervention;novel therapeutics;Other Genetics;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;Physiologic pulse;Point Mutation;postsynaptic;presenilin-1;presynaptic;Presynaptic Terminals;Prevention strategy;protein distribution;Protein Isoforms;Publishing;Reporter;Risk Factors;secretase;Senile Plaques;Swelling;Synapses;Synaptic plasticity;Synaptic Transmission;Synaptic Vesicles;synaptogenesis;synergism;tau-1;Testing;theories;trafficking;trait;treatment strategy;United States National Institutes of Health;Work

PROJECT_TITLE: Membrane cholesterol homeostasis in human brain cells derived from iPSCs

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Autoimmune Disease;Complementary and Integrative Health;Dietary Supplements;Genetics;Immunotherapy;Lung;Lupus;Nutrition;Prevention

ORG_CITY: EAST LANSING

ORG_DEPT: NUTRITION

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Autoimmune diseases (ADs) affect over 25 million Americans, inflicting tremendous individual suffering and societal burdens. Exposure to the earth’s most abundant mineral, crystalline silica (quartz), is common in individuals involved in construction, mining, farming, manufacturing and military deployment and increases their risk of developing systemic lupus erythematosus (lupus) and other ADs. Here we seek to understand the underlying mechanisms by which consumption of the omega-3 fatty acid docosahexaenoic acid (DHA) blocks silica-triggered lupus, thus yielding important new insights into how environmental toxicants trigger AD and how manipulating the lipidome through dietary fatty acid supplementation can prevent it.

PI_NAMEs: PESTKA, JAMES J (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: Acceleration;Acids;Acute;adaptive immunity;Affect;Alveolar;Alveolar Macrophages;American;Autoantibodies;Autoantigens;Autoimmune Diseases;autoimmune rheumatologic disease;Autoimmunity;C57BL/6 Mouse;Cathepsins;Cell Death;Cessation of life;Chemosensitization;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Consumption;cytokine;Data;Development;Diet;dietary;Dietary Fats;Dietary Fatty Acid;dietary supplements;disability;DNA;Docosahexaenoic acid supplementation;Docosahexaenoic Acids;Dose;early onset;Eicosanoids;Embryo;Environment;Environmental Risk Factor;environmental stressor;Excision;Exposure to;Farm;fatty acid supplementation;Fatty Acids;Female;Fetal Liver;Fish Oils;Fishes;Flare;Gene Expression;genetic signature;Genome;Glomerulonephritis;Goals;Grant;Health;Heredity;Human;human disease;Immune Tolerance;immunogenic;immunogenic cell death;Immunotherapy;In Vitro;in vivo;Individual;Infectious Agent;Inflammation;Inflammation Mediators;Inflammatory;insight;Interferons;Interleukin-1;Interleukin-1 alpha;Interleukin-1 beta;Link;lipidome;Lipids;Liver;Lung;Lupus;Lymphoid Tissue;Lysosomes;Macrophage;manufacture;Military Personnel;Minerals;Mining;Mission;Modeling;mouse model;Mus;National Institute of Environmental Health Sciences;Natural Immunity;novel;Omega-3 Fatty Acids;Omega-6 Fatty Acids;particle;Pathway interactions;Phagocytes;Phenotype;Planet Earth;Play;Population;pre-clinical;Predisposing Factor;prevent;Production;Quartz;respiratory;response;Risk;Risk Factors;Role;Rupture;self-renewal;Severities;Silicon Dioxide;stressor;systemic autoimmunity;Systemic Lupus Erythematosus;Testing;Tissues;tool;Toxic Environmental Substances;toxicant;United States National Institutes of Health;Water

PROJECT_TITLE: Role of alveolar macrophage in omega-3 fatty acid amelioration of silica-triggered autoimmunity.

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: STANFORD

ORG_DEPT: DERMATOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE Liquid biopsies are poised to revolutionize diagnostic procedures by making them more accessible and less invasive due to the use of biofluids like blood rather than tissue samples. During my PhD I have helped develop an RNA liquid biopsy platform that the F99 will enable me to lead a validation for in patients diagnosed with lung adenocarcinoma. As an NIDDK K00 fellow, I will expand the RNA liquid biopsy platform into a hematological context that will identify extracellular RNA markers of the hematopoietic lineage in- and ex-vivo.

PI_NAMEs: REGGIARDO, ROMAN E (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: aspirate;Awareness;Biological;Biological Assay;Biology;Blood;Blood Cells;Blood specimen;Bone Marrow;Bone Marrow Aspiration;Bone marrow biopsy;bone marrow mesenchymal stem cell;Cell Count;cell free DNA;Cell Separation;cell type;Cells;Classification;Clinical;Code;cohort;cost;COVID-19 patient;Data;Data Set;Detection;Developmental Cell Biology;Diagnosis;Diagnostic;diagnostic biomarker;Diagnostic Procedure;Disease;Disease Marker;DNA Transposable Elements;Doctor of Philosophy;Ensure;Event;Excretory function;explainable machine learning;extracellular;extracellular vesicles;Fibrosis;Generations;Genetic Transcription;Genomics;Genotype-Tissue Expression Project;Global Change;Goals;Growth;Health;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic Stem Cell Mobilization;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hemorrhage;Human;In Vitro;Individual;Infection;intercellular communication;Label;leukemia/lymphoma;liquid biopsy;Lung Adenocarcinoma;machine learning algorithm;Mediating;member;Mentorship;Mesenchymal Stem Cells;Methylation;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;pain relief;pancreatic cancer patients;Pathology;Patients;Performance;peripheral blood;PET/CT scan;Plasma;Population;Production;programs;Recovery;Research;Research Personnel;RNA;RNA analysis;RNA marker;Sampling;Sedation procedure;side effect;single-cell RNA sequencing;specific biomarkers;stem cell biology;stem cell population;success;Techniques;Testing;The Cancer Genome Atlas;Tissue Sample;Tissues;tool;Training;training data;Transcriptional Regulation;transcriptome sequencing;tumorigenesis;Untranslated RNA;Validation;Whole Blood;X-Ray Computed Tomography

PROJECT_TITLE: Hematopoietic circRNA-mediated intercellular communication


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Hematology;Orphan Drug;Rare Diseases

ORG_CITY: GLASSBORO

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: ROWAN UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative: Over the long-term, this significant and innovative research will determine the efficacy of targeting the anti- apoptotic Bcl-2 family protein Mcl-1 to inhibit refraction and recurrent disease development and improve the efficacy of traditional therapy to increase the number of multiple myeloma patients responding to this treatment. Therefore, the impact on cancer mortality rates could be significant.

PI_NAMEs: PANDEY, MANOJ KUMAR (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Acute;Address;Aftercare;Animal Model;Animals;anti-cancer;Antineoplastic Agents;Apoptotic;Area;Autologous Stem Cell Transplantation;Automobile Driving;BCL2 gene;Biochemical;Biological Assay;Biomedical Research;Bortezomib;cancer cell;Cardiotoxicity;career development;Cell Death;Cell Death Induction;Cell Line;Cell Survival;Cells;chemotherapeutic agent;chemotherapy;Clinical;clinical translation;Clinical Trials;combat;Combined Modality Therapy;Cytotoxic agent;Data;Data Analyses;Death Rate;Development;Dexamethasone;Disease Progression;Education;efficacy evaluation;efficacy study;Evolution;experience;Exposure to;Family;Future;gene discovery;Goals;immunoregulation;improved;In Vitro;in vitro Model;in vivo;inhibitor;innovation;Knowledge;Laboratories;Malignant Neoplasms;Marketing;MCL1 gene;Mediator;medical schools;Medical Students;member;Mentors;minority student;Modeling;Multiple Myeloma;novel;novel therapeutic intervention;overexpression;Pathway interactions;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Plasma Cells;pre-clinical;prevent;Principal Investigator;Process;Proteasome Inhibitor;Protein Family;Proteins;Recurrent disease;Refractory;refractory cancer;Relapse;relapse patients;Research;Research Infrastructure;Resistance;Resistance development;Role;Sampling;Series;side effect;Sorbus;standard of care;Students;Survival Rate;targeted treatment;Testing;Therapeutic;Therapeutic Agents;therapy resistant;Toxic effect;traditional therapy;transcriptome;transcriptome sequencing;translational impact;treatment strategy;tumor;tumorigenic;undergraduate research;Underrepresented Populations;underserved minority;Universities;Validation;Writing

PROJECT_TITLE: Novel Mcl-1 Inhibitor for Combination Treatment of Refractory Multiple Myeloma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDPT-J (80)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer

ORG_CITY: TOLEDO

ORG_NAME: UNIVERSITY OF TOLEDO

ORG_STATE: OH

PHR: PROJECT NARRATIVE Most internal organs consist of a monolayer of polarized epithelial cells surrounding a central lumen, which functions to establish a barrier that segregates the internal medium from the outside environment in tissues and organs. This proposal will uncover the fundamental mechanisms controlling the function of a novel protein complex that coordinates junctional assembly, stability, and turnover in epithelial cells. Understanding the molecular mechanisms of these fundamental processes, which are essential for tissue morphogenesis and organ development, is a major obstacle in our quest to develop therapies treat or prevent epithelial cancers, which are mostly from epithelial origin.

PI_NAMEs: GARCIA-MATA, RAFAEL  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Adhesions;Affect;apical membrane;basolateral membrane;Binding;Biochemical;Biological Assay;Biosensor;Carcinoma;Cell Adhesion;Cell membrane;Cell Polarity;Cell-Cell Adhesion;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Congenital Abnormality;Disease;E-Cadherin;Endocytosis;Environment;Epithelial Attachment;Epithelial Cells;Epithelium;experimental study;Extracellular Matrix;fly;Genetic study;Goals;Guanine Nucleotide Exchange Factors;Homeostasis;Human;innovation;insight;Intercellular Junctions;Larva;Lateral;Link;loss of function;Maintenance;Malignant Neoplasms;Mammalian Cell;Mammals;Mediating;member;Membrane;Microscopy;Molecular;monolayer;Morphogenesis;Normal Cell;novel;Organ;organ growth;Play;polarized cell;prevent;Process;protein complex;Proteins;Publishing;recruit;Recycling;Regulation;rho GTP-Binding Proteins;Role;Route;scaffold;Scaffolding Protein;segregation;Signal Pathway;Signal Transduction;spatiotemporal;Testing;therapy development;Tissues;Transcriptional Regulation;Work

PROJECT_TITLE: Regulation of epithelial junctions stability and turnover by the RhoG exchange factor SGEF

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-B (81)]


ORG_DEPT: SURGERY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative Although, the importance of AR-regulating long non-coding RNA (lncRNA) has long been speculated, the direct negative regulation of AR (and AR-V7) transcription by lncRNA has not yet been reported. Serendipitously, we identified a lncRNA, NXTAR (LOC105373241), located convergently to the AR gene that is repressed in human prostate tumors and cell lines, and discovered that its reinstatement promotes binding upstream of the AR promoter, causing significant loss of expression of AR and its splice variant AR-V7.

PI_NAMEs: MAHAJAN, KIRAN ;MAHAJAN, NUPAM P (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: abiraterone;Acetylation;ACK1 Gene;Address;androgen biosynthesis;androgen independent prostate cancer;Androgen Receptor;Androgen Suppression;antagonist;Antibodies;AR gene;Binding;cancer cell;Cancer Patient;Cell Line;Cell Proliferation;Cells;Clinical;combat;Data;Deposition;design;Disease-Free Survival;Distant;DNA Binding Domain;efficacy evaluation;Encapsulated;Enhancers;Environment;enzalutamide;Epigenetic Process;Ethylenes;Exclusion;Exons;extracellular;FOLH1 gene;gene repression;Generations;Genetic Transcription;histone acetyltransferase;Histone H2B;Human;Imines;Immune response;in vivo;inhibitor;insight;iron oxide nanoparticle;Isocitrate Dehydrogenase;Luciferases;Malignant neoplasm of prostate;Messenger RNA;Modality;Modification;nanocarrier;nanocrystal;nanoparticle;NCOR2 gene;Neoplasm Metastasis;novel;novel therapeutics;Nuclear Translocation;oligonucleotide therapeutics;Oligonucleotides;Organ;overexpression;patient derived xenograft model;Patients;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Phosphotransferases;Play;Proliferating;promoter;Prostate;prostate cancer cell;prostate cancer model;Prostatic Neoplasms;receptor binding;Receptor Signaling;recruit;Recurrence;Regulation;Reporting;Repression;Resistance;Resistance development;response;restoration;RNA Splicing;Role;Series;Small Interfering RNA;small molecule inhibitor;superparamagnetism;Testing;Therapeutic;Tissues;Toxic effect;Transcriptional Activation;tumor;tumor growth;tumor microenvironment;Tumor Suppressor Genes;tumor xenograft;Untranslated RNA;Variant

PROJECT_TITLE: Regulation of Androgen Receptor by NXTAR Long non-coding RNA in Prostate Cancer and its Therapeutic Implications

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Physical Injury - Accidents and Adverse Effects;Social Determinants of Health;Substance Misuse

ORG_CITY: OMAHA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA OMAHA

ORG_STATE: NE

PHR: PROJECT NARRATIVE Early life adversity significantly alters the trajectory to develop substance use disorders. These experiments use longitudinal animal models to manipulate a critical developmental period and utilize neuropharmacology and behavioral methods to reveal modulatory mechanisms of opioid reward and consummatory behaviors. Meeting these objectives will identify a critical developmental window and neurobiological alterations in serotonin receptor function that create vulnerable and resilient phenotypes in the context of opioid use disorder.

PI_NAMEs: GARCIA, ERIK JOSEPH (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: abuse liability;Address;Adolescence;adverse childhood events;Adverse event;Affect;Age;Agonist;American;Animal Model;antagonist;Area;Behavioral;behavioral economics;Brain;Brain region;Chronic stress;Cognition;Communication;Complex;Consummatory Behavior;Consumption;COVID-19 pandemic;critical developmental period;Cues;Data;Development;Dose;Drug Modelings;drug of abuse;drug reinforcement;early life adversity;efficacy evaluation;Elasticity;Environment;experience;experimental study;Exposure to;Family;Fentanyl;fentanyl analog;fentanyl self-administration;fentanyl use;Fluorescent in Situ Hybridization;Fostering;Goals;Growth;healing;Health;Height;HTR2A gene;Human;Injections;innovation;Learning;Life;Measures;Medial;medication for opioid use disorder;meetings;Mental disorders;Messenger RNA;Methods;Modeling;monoamine;Moods;Motivation;mRNA Expression;Nebraska;neurobiological mechanism;Neurobiology;Neurons;Neuropharmacology;Neurosciences;new therapeutic target;non-opioid analgesic;nonlinear regression;novel;novel therapeutics;Opioid;opioid epidemic;opioid misuse;opioid mortality;opioid overdose;opioid use disorder;Outcome;overdose death;Overdose reduction;Oxycodone;Pathway interactions;pediatric trauma;Persons;Pharmaceutical Preparations;Phenotype;Populations at Risk;Positioning Attribute;Pre-Clinical Model;Prefrontal Cortex;prescription opioid;Prevalence;programs;Psychological reinforcement;Public Health;Publications;Rattus;receptor;Receptor Activation;receptor expression;receptor function;Recovery;recruit;reinforcer;Relapse;Research;Research Project Grants;resilience;reward processing;Rewards;Rodent;Self Administration;Serotonergic System;Serotonin;serotonin receptor;Serotonin Receptor 5-HT2A;Serotonin Receptor 5-HT2C;Signal Transduction;skills;small molecule;social contact;Stress;Structure;student participation;Students;substance misuse;Substance Use Disorder;Support System;symposium;synthetic opioid;System;Theoretical model;Therapeutic;Tissues;Training;training opportunity;Treatment Efficacy;treatment strategy;undergraduate research;undergraduate student;Universities

PROJECT_TITLE: Developmental and Serotonin 5-HT2A Receptor Effects on Fentanyl Reinforcer Value

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Climate-Related Exposures and Conditions

PHR: Narrative Microcystins (MCs), anabenopeptins (APs), and cyanopeptolins (CPs) are toxic cyanopeptides that exist as multiple congeners and appear during harmful cyanobacterial blooms in Lake Erie and other water bodies. To avoid a potential threat to citizens that use those waterbodies as source of drinking water or other activities, the structures and toxicities of previously unreported congeners of these cyanotoxins must be investigated. Identification and purification of novel MC, AP, and CP congeners and will enable important investigation of their toxicities.

PI_NAMEs: ISAILOVIC, DRAGAN  (contact)

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: Address;Aerosols;Affect;Amino Acid Sequence;Amino Acids;Binding;Biological Assay;Biopsy;Cell Culture Techniques;cell injury;Cells;Collection;Complement;contaminated water;Coupled;Cyanobacterium;cyanoginosin LR;Cyanotoxin;Cyclic Peptides;Cysteine;Data;Databases;Derivation procedure;Detection;detection sensitivity;detector;Disease;drinking water;Drug Metabolic Detoxication;Environment;Exposure to;Fluorescence;Fluorescence Spectrometry;Gases;Goals;Health;Hepatocyte;Hepatotoxicity;High Pressure Liquid Chromatography;Human;Hydrophobicity;Hydroxyproline;imaging study;improved;innovation;Intoxication;Investigation;Kidney;kidney cell;Laboratories;Liquid Chromatography;liquid chromatography mass spectrometry;Liver;mass spectrometer;mass spectrometric imaging;Mass Spectrum Analysis;Measurement;Methodology;Methods;microcystin;Microcystis aeruginosa;Modeling;Modernization;Molecular Sieve Chromatography;Mus;NMR Spectroscopy;novel;Ohio;optical spectra;Organ;Oxygen;Periodicity;Phase;Phenylalanine;Phosphoric Monoester Hydrolases;Preparation;prevent;Protein Inhibition;Protein phosphatase;Proximal Kidney Tubules;Research;Resolution;Sampling;screening;Serine;Source;Structure;Sulfhydryl Compounds;Sulfhydryl Reagents;Sulfoxide;Sulfur;tandem mass spectrometry;Testing;tool;Toxic effect;Toxicology;Tryptophan;Tyrosine;Water;water sampling

PROJECT_TITLE: Discovery of Novel Cyanotoxins by Detection of Their Native Fluorescence and Unique MS/MS Fragments, and Determination of Their Toxicities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-Y (82)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Rural Health;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: The Partners Engaged in Equity Research Hub (PEER Hub), leverages our institutional and national networks and training and technical assistance (TTA) expertise to support community-led interventions to advance health equity, especially in the areas of neighborhood and built environment, social and cultural context, access and quality of community health care services, economic development, and nutrition and food environment. Working in close collaboration with the ComPASS Coordinating Center and a multidisciplinary panel of experts (MEP), the UM PEER Hub will provide locally relevant proactive technical assistance to assigned CHESI projects to support high quality implementation and future sustainability of the community-led research initiatives.

PI_NAMEs: HEINZE, JUSTIN EDWARD;MEHDIPANAH, ROSHANAK  (contact)

PROGRAM_OFFICER_NAME: MOMIN, BEHNOOSH RAMJI

PROJECT_TERMS: Address;Advocate;Area;Behavior;built environment;Collaborations;Communication;Communities;community academic partnership;community based participatory research;community collaboration;community empowerment;community engagement;Community Health;Community Healthcare;community led intervention;community organizations;community partnership;Consultations;Crime;Data;data harmonization;data infrastructure;Discrimination;Disparity;Economic Development;Economics;Education;Employment Opportunities;empowerment;Ensure;Equity;experience;food environment;Fostering;Future;Goals;Health;health care availability;health care service;health disparity;health equity;Health equity research;Health Food;health inequalities;Health Resources;Improve Access;Infrastructure;innovation;Institution;Intervention;Investments;Knowledge;lens;Mentors;Mentorship;Methods;Michigan;minority communities;Modality;multidisciplinary;Neighborhoods;next generation;nutrition;Occupations;Ownership;Policies;Politics;Population;Process;programs;Public Health Schools;Race;Research;research data dissemination;Research Personnel;research study;research to practice;Resources;Scholars Program;science and society;Site;social;Social Conditions;social health determinants;Societies;socioeconomics;stem;structural determinants;support network;Sustainable Development;Training;Training Programs;Translations;United States National Institutes of Health;Universities;Violence;Work

PROJECT_TITLE: Partners in Research: Building capacity for community-driven research to advance health equity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-P (52)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PHR: Project Narrative Environmentally benign organosilanes are increasingly utilized in an impressively wide range of synthetic applications pertaining to biomedically significant agents, catalysts, and drug delivery systems. The objectives of the proposed research program are to establish new, efficient synthetic strategies for the rapid and selective generation of various high-value synthetic building blocks and biologically significant molecules. Achieving success in these endeavors will expedite the utilization of a range of novel small molecules in drug discovery and development, ultimately contributing to the advancement of human health.

PI_NAMEs: JEON, JUNHA  (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TITLE: Catalytic Reductive C-H and C-C Silylation with Silyl Acetals

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: ROCKVILLE

ORG_NAME: SANARIA, INC.

ORG_STATE: MD

PHR: PUBLIC HEALTH RELEVANCE (Project Narrative) The ideal, most efficient and cost-effective tool to reduce, eliminate and eventually eradicate malaria, which has devastating effects causing 241 million clinical cases and 627,000 deaths worldwide in 2020 alone, would be a highly effective, long-acting vaccine that prevents infection, disease and parasite transmission. Sanaria® PfSPZ vaccines are the leading candidates that fit these characteristics. This proposal will accelerate the licensure and marketing of the safest and most protective PfSPZ vaccine (anticipated to be PfSPZ-LARC2) by providing support for the Quality Assurance, Quality Control, Manufacturing, Regulatory and Clinical tasks required for the submission of licensure applications in Europe and the US.

PI_NAMEs: HOFFMAN, STEPHEN LEV (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Acceleration;Address;Affect;Africa;African;African Women;Attenuated;Attenuated Vaccines;attributable mortality;Authorization documentation;Cessation of life;Characteristics;Child;child bearing;Clinical;clinical development;Clinical Trials;Clinical Trials Design;Code;commercialization;commercialization readiness;Communicable Diseases;Communication;Computer Systems;Contracts;cost effective;Country;COVID-19;Cryopreservation;Databases;design;Development;Development Plans;Disease;Dose;Ensure;Europe;European;Falciparum Malaria;Feedback;Funding;Generations;Glass;Goals;Grant;Hospitalization;Human;Immunize;implementation trial;Individual;Infant;Infection;Infection prevention;Infrastructure;innovation;Investments;Licensure;Liver;Malaria;malaria infection;malaria transmission;Malaria Vaccines;manufacture;Marketing;Medicine;meetings;Mission;Morbidity - disease rate;mortality;novel vaccines;Parasites;Persons;Pharmaceutical Preparations;Phase;Plasmodium falciparum;Plasmodium falciparum vaccine;Pregnancy;Pregnant Women;prevent;Procedures;Process;Production;Program Development;programs;protective efficacy;Public Health;public health intervention;public health relevance;Qualifying;quality assurance;Quality Control;Radiation;Readiness;Recommendation;Regulation;Reporting;response;Safety;Sales;Seasons;Soldier;Sporozoite vaccine;stem;stillbirth;success;Technology;technology development;Time;tool;transmission process;Travel;Vaccination;vaccine efficacy;vaccine trial;Vaccines;Validation;Vial device

PROJECT_TITLE: Progressing PfSPZ vaccines for malaria to licensure and commercialization


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Genetics;Physical Activity;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: BOISE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOISE STATE UNIVERSITY

ORG_STATE: ID

PHR: Project Narrative This proposal aims to develop targeted, non-pharmacologic interventions to increase DNA repair in healthy cells decreasing chemotherapy-linked stem cell senescence to improve clinical outcomes and quality of life in cancer survivors. This project will yield a novel understanding of how external mechanical force in the form of low intensity vibration can decrease side effects and long-term sequelae following chemotherapeutic treatment modalities.

PI_NAMEs: ZAVALA, ANAMARIA GABRIELLA (contact)

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: adduct;Apoptosis;Biomedical Engineering;Biomedical Research;bone;bone cell;bone loss;bone quality;Breast;cancer cell;Cancer Patient;Cancer Survivor;Cell Aging;Cell Cycle Checkpoint;cell killing;Cell Survival;Cells;Cerebral Palsy;Cervical;chemotherapy;Chemotherapy-Oncologic Procedure;Chromatin;Cisplatin;cisplatin-DNA adduct;Clinical;clinically relevant;Complex;Cytoskeleton;Data;disabled;Disabling;Disabling condition;DNA;DNA Adducts;DNA Damage;DNA Repair;Doctor of Philosophy;Dose;Down-Regulation;Education;Effectiveness;Elements;ERCC1 gene;Excision;Exercise;experience;Fatigue;Foundations;Frequencies;GADD45A gene;Idaho;improved;indexing;Individual;Intervention;Kinetics;Link;live cell imaging;long-term sequelae;Malignant Neoplasms;mechanical force;Mechanical Stress;Mechanics;mechanotransduction;Mediating;Modality;Modeling;Molecular Target;mortality;Muscle Contraction;Mutagenesis;Neoplasm Metastasis;neurotoxicity;Nonpharmacologic Therapy;novel;Nucleotide Excision Repair;Nucleotide Excision Repair Inhibition;Oncologist;Outcome;Ovarian;overexpression;Pathway interactions;Patients;Pharmaceutical Preparations;Physical activity;Platinum;Population;prevent;Process;programs;protein complex;Publications;Quality of life;quality of life for cancer survivors;Recovery;Regimen;Regulation;Repair Complex;repaired;Research;Research Personnel;response;Role;senescence;side effect;stem cells;Stress;Students;Surgical incisions;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Tissues;Toxic effect;Toxicity due to chemotherapy;Treatment Efficacy;undergraduate student;Universities;Uterus;UV induced;vibration;wasting;Work

PROJECT_TITLE: The Role of Mechanical Stress in Mitigating Side Effects of Chemotherapy


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Immunization

ORG_CITY: DE KALB

ORG_NAME: NORTHERN ILLINOIS UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative Antibodies play a vital and growing role in life science applications, such as protein therapeutics. The research described in this proposal is designed to explore new methods to generate pH dependent antibodies. The relevance of this project to public health is two-fold: (1) it will provide new opportunities for the use of antibodies to preferentially target certain microenvironments, such as that found in cancerous tumors, and (2) it will provide fundamental insight towards the development and novel use of protein reagents for life science applications.

PI_NAMEs: HORN, JAMES R. (contact)

PROJECT_TERMS: Address;Advanced Development;Affinity;Antibodies;antibody and antigen binding;antibody engineering;antibody libraries;antigen binding;Antigens;Applications Grants;Aspartic Acid;Binding;Binding Proteins;Biological;Biological Assay;Biological Sciences;biophysical chemistry;Biophysics;Biosensor;Cancerous;Cells;Cellular biology;Characteristics;combinatorial;cost;Coupled;Custom;Dependence;design;Development;Diagnostic;Drops;Electrostatics;Engineering;Epitopes;Event;experience;experimental study;gain of function;Generations;Goals;Histidine;Horns;Immunoassay;Immunoglobulin Fragments;improved;insight;interest;ionization;Kinetics;Knowledge;Libraries;Link;Methodology;Methods;Modeling;Molecular Biology;molecular imaging;Nanotechnology;next generation;novel;Outcome;Phage Display;Play;Property;Protein Engineering;protein protein interaction;Proteins;protonation;Public Health;Reagent;receptor;Regulation;Research;Role;Scanning;Site;structural biology;Structure;System;Testing;Therapeutic;Therapeutic antibodies;therapeutic protein;Thermodynamics;trigger point;tumor;tumor microenvironment;Variant;Work

PROJECT_TITLE: Engineering and Characterization of pH dependent Antibodies


ORG_CITY: AUSTIN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because defects in membrane remodeling underlie debilitating diseases from cancer to neurological disorders, and because membrane trafficking vesicles serve as the cellular entry mechanism for both harmful pathogens and therapeutic drugs. Therefore, the proposed research on the basic physical mechanisms underlying membrane remodeling is relevant to the part of NIH’s mission that seeks to develop fundamental knowledge that will help to reduce the burdens of human disability and disease. Ultimately, it is envisioned that a fundamental understanding of membrane remodeling will enable therapeutic manipulation of membrane traffic and other points of intersection between membranes and disease.

PI_NAMEs: STACHOWIAK, JEANNE CASSTEVENS (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Area;Behavior;Biological Process;Biology;Cell Physiology;Cells;Clathrin;Coupled;Defect;Diabetes Mellitus;disability;Disease;driving force;Endocytosis;Event;Filopodia;flexibility;Human;human disease;In Vitro;Individual;insight;Integral Membrane Protein;Knowledge;Liquid substance;Malignant Neoplasms;Mediating;Membrane;Membrane Protein Traffic;Mission;Modeling;Molecular;Needles;Nervous System Disorder;novel;pathogen;Pathway interactions;Pharmaceutical Preparations;pressure;Proteins;Public Health;receptor recycling;Research;Role;scaffold;Shapes;Structure;Structure-Activity Relationship;Surface;Tertiary Protein Structure;Therapeutic;trafficking;United States National Institutes of Health;Vesicle;Virus Replication;Work

PROJECT_TITLE: Protein Networks as Synergistic Drivers of Membrane Remodeling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: PITTSBURGH

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PUBLIC HEALTH NARRATIVE. Loss-of-function mutations in PTEN-induced kinase 1 (PINK1) contribute to a recessive form of Parkinson's disease with early cognitive dysfunction. In the prior grant period, we discovered that loss of PINK1 results in diminished numbers of dendritic spines, particularly the type of spine most closely associated with long- term memory storage. We will determine whether mitochondrial transport into dendrites is impaired by loss of PINK1, and how PINK1 activity regulates brain cell responses involved in learning and memory in cultured mouse and human neurons. These studies will help identify new strategies to prevent or slow the loss of brain cell function in Parkinson's disease and related neurodegenerative dementias.

PI_NAMEs: CHU, CHARLEEN T (contact);WILLS, ZACHARY P

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Affect;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease related dementia;autosome;Axon;Binding;Biochemical;brain cell;Brain region;Calcium;Cell Physiology;cofactor;Cognitive;cognitive function;cognitive impairment in Parkinson's;Cyclic AMP-Dependent Protein Kinases;Data;Dementia;Dendrites;Dendritic Spines;density;Disease;Distant;Dynein ATPase;early onset;Electrophysiology (science);Executive Dysfunction;Exhibits;Frequencies;Frontotemporal Dementia;genetic manipulation;Glutamates;Grant;Health;Heterozygote;Hippocampus;Homeostasis;Human;Image;Immunoprecipitation;Impaired cognition;Impairment;In Vitro;in vivo;induced pluripotent stem cell;insight;Learning;Lewy Body Dementia;live cell imaging;long term memory;Long-Term Potentiation;loss of function;loss of function mutation;Mass Spectrum Analysis;Mediating;Memory;Mitochondria;Mitochondrial Proteins;Molecular;Molecular Genetics;Motility;Motor;motor symptom;Mus;Mutate;Mutation;Nerve Degeneration;neurodegenerative dementia;Neurodegenerative Disorders;neuronal cell body;Neuronal Plasticity;Neurons;neuroprotection;novel;Parkinson Disease;Parkinson's Dementia;patient derived induced pluripotent stem cells;Patients;Phosphorylation;Phosphorylation Site;Phosphotransferases;photoactivation;PINK1 gene;Play;Positioning Attribute;prevent;Process;Proteins;Public Health;Regulation;response;Role;Signal Pathway;Site;Slice;sporadic Parkinson's Disease;Synapses;synaptic function;Synaptic plasticity;Testing;valosin-containing protein;Vertebral column

PROJECT_TITLE: Dendrite regulation by the mitochondrial kinase PINK1: Implications for PD/LBD

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ORG_CITY: FARGO

ORG_NAME: NORTH DAKOTA STATE UNIVERSITY

ORG_STATE: ND

PHR: PROJECT NARRATIVE  Alkyne hydrofunctionalization is a fundamentally important and challenging organic transformation for atom-efficient construction of carbon-heteroatom bonds from abundant building blocks. Our proposed research aims to advance the method development and mechanism understanding of nickel-catalyzed alkyne hydrofunctionalization reactions assisted by alkyne-tethered directing groups. This work will provide new synthetic methods for heteroatom-containing molecules that are valuable in biomedical research and drug development.

PI_NAMEs: YAN, CHANGHUI ;ZHAO, PINJING  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Acetals;Affect;Alcohols;Alkynes;Amides;Amines;Ammonia;aryl halide;Biomedical Research;carbene;Carbon;Catalysis;catalyst;chelation;chemical synthesis;Claisen rearrangement;Complex;computer studies;Coupling;design;Development;drug development;drug discovery;drug synthesis;Evaluation;experimental study;Face;feasibility research;functional group;Goals;Hydrogen;Imines;improved;innovation;insight;Investigation;Ketones;Kinetics;Ligands;Machine Learning;method development;Methods;Nickel;Nitrogen;novel;oxidation;Oxygen;Pharmaceutical Chemistry;Process;Publishing;pyridine;rational design;Reaction;Research;research and development;Structure;success;Testing;vinyl ether;Water;Work

PROJECT_TITLE: Rational Design of Nickel Catalysts for Directing Group-Assisted Alkyne Hydrofunctionalization


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

ORG_CITY: MURFREESBORO

ORG_NAME: MIDDLE TENNESSEE STATE UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative Neuropeptides play a critical role in cell signaling, mediating development, physiology, and behavior. Abnormalities in the synthesis, trafficking or release of neuropeptides have been strongly linked with a wide range of neurological and neurodegenerative diseases and disorders like Alzheimer’s. Completion of these studies will elucidate potential mechanisms, pathways, and proteins that could be candidate targets for genetic and pharmacological treatments once their roles in governing neuropeptides in the nervous system are illuminated.

PI_NAMEs: ORMEROD, KIEL  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Acute;Adaptor Signaling Protein;Alzheimer's Disease;Animals;Behavior;Behavioral;Biology;Brain;Calcium;Cells;Chemicals;Cloning;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;Communications Media;Complement;Complex;Comprehension;Data;Dense Core Vesicle;Development;Disease;Drosophila genus;Electron Microscopy;Electrophysiology (science);Enzymes;Event;Family;Fluorescence Microscopy;fly;Genetic;Genome;Golgi Apparatus;Hormones;Human;Image;in vivo;Individual;Intracellular Transport;Kinesin;Lead;Link;MAPK8 gene;Mediating;Messenger RNA;mimetics;Modeling;Modernization;Molecular;Motor;Motor Neurons;Mutate;Mutation;Nervous System;Nervous System Disorder;Neurodegenerative Disorders;Neurons;Neuropeptides;novel;Pathway interactions;Peptide Signal Sequences;Peptides;pharmacologic;Pharmacological Treatment;Phosphotransferases;Physiological;Physiology;Play;Population;Process;protein complex;protein function;protein structure;Proteins;recruit;Reporting;Research;Role;Signal Transduction;Signaling Molecule;Site;Societies;Sorting;Specificity;Synapses;synaptotagmin;synaptotagmin IV;System;Techniques;Tertiary Protein Structure;Testing;Time;Tissues;trafficking;trans-Golgi Network;Transcript;Transgenic Organisms;Translating;ultra high resolution;Vesicle;Visualization

PROJECT_TITLE: Mechanisms of intracellular transport and processing of neuropeptides

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_DEPT: SOCIAL SCIENCES

PHR: The goals of the Center for ELSI Resources and Analysis (CERA), and its web portal ELSIhub, are to serve as a locus for resource sharing and community building to enhance the production, sharing, and use of research on the ethical, legal, and social implications of genetics and genomics (ELSI research).

PI_NAMEs: CHO, MILDRED K. (contact);LEE, SANDRA SOO-JIN

PROGRAM_OFFICER_NAME: LOCKHART, NICOLE C

PROJECT_TITLE: ELSIhub: National Center for ELSI Resources and Analysis

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-P (M2)]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE This research will provide fundamental knowledge on how cognitive reserves and social interactions play roles in shaping older immigrants’ cognitive health in the context of senior housing. The application of this knowledge will inform researchers and aging service community organizations to develop network-based interventions to promote the cognitive health of older ethnic immigrants in underserved communities.

PI_NAMEs: JANG, YURI  (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Acculturation;Aging;aging in place;aging population;Alzheimer's disease related dementia;Area;bullying;Characteristics;Cognitive;cognitive reserve;cognitive testing;commune;Communities;community organizations;Community Services;Compensation;Conflict (Psychology);Data;density;design;Dimensions;Education;Environment;Ethnic Origin;experience;Family;Family member;Focus Groups;Funding;Goals;Health;Health Promotion;Home;Housing;Immigrant;Immigration;Impaired cognition;improved;innovation;interest;Intervention;Knowledge;Korean American;Koreans;Language;Life Cycle Stages;Limited English Proficiency;Linguistics;Los Angeles;Management Service Organizations;Measures;Methods;Names;Nature;Network-based;Participant;Pathway Analysis;Pattern;peer;Perception;Personal Satisfaction;Persons;Play;recruit;Research;Research Personnel;Resources;response;Risk;Role;Series;service organization;Services;Shapes;Site;social;social determinants;Social Interaction;Social Network;social vulnerability;socioeconomic disadvantage;Source;Standardization;Stereotyping;Surveys;theories;Translating;underserved community;United States National Institutes of Health;Visualization;Work

PROJECT_TITLE: Social Interactions and Cognitive Health in Older Immigrants:  Bonding/Bridging/Bullying in Senior Housing

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-9 (M1)]


ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Lung;Neurosciences;Sleep Research

ORG_CITY: GLENDALE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: MIDWESTERN UNIVERSITY (GLENDALE AZ)

ORG_STATE: AZ

PHR: Project Narrative During sleep, patients who suffer from obstructive sleep apnea stop breathing many times a night because upper airway muscles including the tongue collapse and block the airway, which leads to cyclically low levels of oxygen. This project will test the hypothesis that the cyclical low levels of oxygen change the effects of acetylcholine (normally released during sleep) at the motoneurons that control the tongue. This proposal will advance understanding of this important mechanism that regulates airway tone during sleep to facilitate discovery of potential novel treatment options for obstructive sleep apnea.

PI_NAMEs: REVILL, ANN LOUISE (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Acetylcholine;Adult;Age;airway muscle;American;Apnea;Blood;Brain Stem;brain tissue;Breathing;Cells;cholinergic;Chronic;Compensation;Confocal Microscopy;Data;Development;Diagnosis;Drops;Electrophysiology (science);Equilibrium;Exhibits;experience;Exposure to;Funding;G protein-coupled inwardly-rectifying potassium channel;Goals;graduate student;Health;Hypoxia;Immunofluorescence Immunologic;improved;In Vitro;in vivo;Individual;Investigation;Ion Channel;Laboratories;Mediating;Methods;Mission;Motor Neurons;Mus;Muscarinic Acetylcholine Receptor;Muscarinic M2 Receptor;Muscarinics;Muscle;National Heart, Lung, and Blood Institute;Neonatal;neonatal mice;Nerve;Neuroanatomy;neurochemistry;Neurons;new therapeutic target;next generation;noradrenergic;novel;novel therapeutics;Obstructive Sleep Apnea;Outcome;Oxygen;Patients;Pattern;Periodicity;Persons;pharmacologic;Population;postnatal;postsynaptic;Predisposition;Preparation;professional students;Property;rapid eye movement;receptor;receptor expression;Recurrence;REM Sleep;Research Project Grants;respiratory;response;Rodent;Secondary to;sex;Signal Transduction;Sleep;Sleep Apnea Syndromes;Slice;Students;Synapses;System;Techniques;Testing;therapeutic target;Tongue;Training;training opportunity;United States National Institutes of Health;Wakefulness;Work

PROJECT_TITLE: Effects of chronic intermittent hypoxia on cholinergic modulation at hypoglossal motoneurons

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-D (80)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Bioengineering;Biotechnology;Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: Foster City

ORG_NAME: ACROBAT GENOMICS, INC.

PHR: Project Narrative Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neurological disease in which motor neurons degenerate, thereby leading to paralysis and death due to respiratory failure. There are no existing therapies that specifically target the repeat expansions in the C9ORF72 gene that are known to cause ALS. Acrobat Genomics will protein engineer optimized and compact RNA- guided nucleases to precisely target and deplete repeat-bearing C9ORF72 transcripts as a potential therapeutic for patients with ALS.

PI_NAMEs: HUGHES, NICHOLAS  (contact)

PROGRAM_OFFICER_NAME: MARTIN, ZANE

PROJECT_TERMS: Academia;Address;Adult;Adverse event;Age of Onset;Alleles;Amyotrophic Lateral Sclerosis;amyotrophic lateral sclerosis therapy;Antisense Oligonucleotides;base editing;Biological Assay;Biotechnology;Businesses;c9FTD/ALS;C9ORF72;Capital;career development;Caregivers;causal variant;Cell Therapy;Cells;Cessation of life;Clinical;commercialization;Complementary DNA;Couples;CRISPR/Cas technology;Development;Dipeptides;Disease;disorder subtype;DNA;Doctor of Philosophy;Down-Regulation;Emotional;Engineering;Event;experimental study;FDA approved;Foundations;Frontotemporal Dementia;Functional disorder;gene editing technology;gene therapy;Generations;Genes;Genetic;Genetic Diseases;Genomics;Goals;Guide RNA;high throughput screening;Human;Human Cell Line;human old age (65+);Impairment;in vivo;Incidence;induced pluripotent stem cell;Investigation;Knock-in;Knock-out;Language;Lead;Link;loss of function;Machine Learning;Measurement;Measures;Mentors;Mitochondria;Modeling;Motor;motor neuron degeneration;Motor Neurons;mutant;Mutation;Names;Nervous System Disorder;neurotoxicity;novel;novel therapeutics;nuclease;older adult;Oligonucleotides;Paralysed;Pathogenesis;Pathogenicity;patient population;patient subsets;Patients;Peptides;Persons;Phase;Phase III Clinical Trials;phenylmethylpyrazolone;Production;Protein Engineering;protein TDP-43;Proteins;Quality of life;Rare Diseases;Research;Research Personnel;Respiratory Failure;Riluzole;RNA;RNA Interference;RNA Splicing;RNA-Binding Proteins;screening;Small Business Innovation Research Grant;Specificity;superoxide dismutase 1;System;Technology;Therapeutic;therapeutic development;timeline;Toxic effect;Transcript;United States;Universities;Variant;vector;Work

PROJECT_TITLE: High-throughput optimization of gene editing systems for treating Amyotrophic lateral sclerosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-I (M1)]


ADMINISTERING_IC: EY

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative Control of protein synthesis by translational regulation is a critical layer of regulation for development and homeostasis of the nervous system. When this process goes awry, it can lead to the onset of developmental and degenerative neurological disorders. This proposal will investigate the cellular and molecular mechanisms that coordinate translational regulatory networks associated with neuron specification and wiring, providing fundamental insights that can be translated into therapeutics.

PI_NAMEs: LOKER, RYAN E (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Address;Adult;Atlases;axon guidance;Bioinformatics;Biological Assay;Biological Models;Birth;Caring;Cell Physiology;cell type;Cells;cholinergic;Chromatin;data dissemination;derepression;design;Development;Drosophila genus;Engineering;Epigenetic Process;experimental study;fly;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic;Genetic Transcription;Genome;genome-wide;genome-wide analysis;Glutamates;Growth;Health;Homeostasis;Human Development;Impairment;improved;Individual;insight;Invertebrates;Ion Channel;Link;Machine Learning;Messenger RNA;Methods;MicroRNAs;Modeling;Molecular;Morphology;mRNA Translation;Nervous System;nervous system development;neural;Neurodegenerative Disorders;neurodevelopment;Neuronal Differentiation;Neurons;Neurosciences;neurotransmission;Neurotransmitters;Optic Lobe;Organ;Pathway interactions;Pattern;Physiology;Post-Transcriptional Regulation;Process;Protein Biosynthesis;Proteins;Regulation;Repression;Reproducibility;Research;ribosome profiling;RNA;RNA-Binding Proteins;RNA-Protein Interaction;Role;Sensory;sensory system;Shapes;Signal Pathway;single cell genomics;single-cell RNA sequencing;Specific qualifier value;Subcellular Spaces;Synapses;System;Technical Expertise;Techniques;technological innovation;Testing;Therapeutic;Tissues;tool;Training;Transcript;transcriptome;transcriptomics;Translating;Translational Regulation;Translational Repression;Translations;Vertebrates;Visual System;Work;Writing

PROJECT_TITLE: Translational control of a complete developing sensory circuit

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: PROJECT NARRATIVE Nucleobases are critical for nucleic acid synthesis, macromolecules that are essential for all forms of life. This proposal focuses on identifying mechanisms used by Clostridioides difficile to salvage an unconventional, toxic, modified uracil nucleobase from the vertebrate gastrointestinal tract, an environment depleted of conventional nucleobases. Completion of studies proposed herein has the potential to define a cellular pathway for detoxifying and utilizing 4-thiouracil as a nucleobase source and elucidate the importance of 4-thiouracil metabolism during C. difficile pathogenesis.

PI_NAMEs: MUNNEKE, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: 16S ribosomal RNA sequencing;4-thiouracil;acute care;Aeromonas;Animal Model;Antibiotic Therapy;antibiotic-associated diarrhea;Antibiotics;base;Base Pairing;Cells;Cessation of life;Clostridium difficile;colonization resistance;Communities;competitive environment;Data;Diarrhea;Disease;Drug Metabolic Detoxication;enteric pathogen;Enterobacteriaceae;Environment;Enzymes;Escherichia coli;experimental study;Family;feeding;gastrointestinal epithelium;Gastrointestinal tract structure;gene product;Genes;Genetic Code;genetic information;Growth;gut microbiota;Health Care Costs;Health care facility;High-Throughput Nucleotide Sequencing;Histopathology;Homologous Gene;Immune system;Infection;innovation;Invaded;Life;macromolecule;Mass Spectrum Analysis;Mediating;member;Metabolic;Metabolic Pathway;Metabolism;microbiota;microorganism;Modeling;Molecular;Mus;mutant;Names;new therapeutic target;Nucleic Acids;nucleobase;Nucleotides;Nutrient;Nutritional;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;prevent;Process;Protein Biosynthesis;Proteins;Pseudomembranous Colitis;Pyrimidine;Reporting;Reproduction spores;Role;Site-Directed Mutagenesis;Source;stressor;targeted treatment;Testing;Therapeutic Intervention;Thiouracil;Toxic effect;Toxic Megacolon;Toxin;United States;Uracil;Work

PROJECT_TITLE: Clostridioides difficile nucleobase scavenging in the competitive gut environment


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: Project Narrative An estimated two out of three Americans experience some form of cognitive impairment, ranging from mild to severe dementia, by age 70. There is a need to understand the molecular and epigenetic regulation of memory in the aging brain to develop therapeutic intervention strategies to preserve cognitive function in old age. The experiments in this proposal will determine if HDAC3 phosphorylation is necessary and sufficient mechanism for HDAC’s epigenetic regulation of long-term memory formation in the young and aging brain an if dysregulation in this mechanism contributes to age-related memory impairments.

PI_NAMEs: RODRIGUEZ, ALYSSA CRYSTAL (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Address;Adult;Age;age related;age related changes;Age-associated memory impairment;age-related disease;Aging;aging brain;aging hippocampus;Alzheimer's Disease;Alzheimer's disease patient;American;ATAC-seq;Bioinformatics;Brain;Cancer Biology;cancer cell;career;Caring;ChIP-seq;Chromatin Structure;Co-Immunoprecipitations;Cognitive deficits;cognitive function;Data;Dementia;Development;Early Intervention;Environment;Epigenetic Process;epigenetic regulation;experience;experimental study;Failure;Fellowship;Female;Foundations;Gene Expression;Gene Expression Profiling;Genes;Genetic;Genetic Transcription;Goals;HDAC3 gene;healthy aging;Hippocampus;Histone Acetylation;histone acetyltransferase;Histone Deacetylase;Histone Deacetylase Inhibitor;Human;human old age (65+);Impaired cognition;improved;Individual;Intervention;Learning;Learning Difficulty;long term memory;Long-Term Potentiation;male;Measures;Memory;memory consolidation;Memory impairment;Molecular;Molecular Neurobiology;Mus;mutant;Nerve Degeneration;neuropathology;novel;older adult;Older Population;Phosphoric Monoester Hydrolases;Phosphorylation;Physiology;Population;preservation;Prevalence;Protein Dephosphorylation;protein protein interaction;Research;Research Personnel;Resources;Rodent Model;Role;Serine;Site;Slice;synaptic function;Synaptic plasticity;Testing;Therapeutic Intervention;tool;Training;Transcription Process;transcriptome sequencing;upstream kinase;Viral;Virus;Western Blotting;Wood material;young adult

PROJECT_TITLE: Investigating HDAC3 phosphorylation as an epigenetic regulator of memory formation in the adult and aging brain


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Ischemic heart disease affects more than 197 million patients worldwide every year and is a leading cause of morbidity and mortality. The goal of this proposal is to investigate the endogenous mechanisms of angiogenesis and myocardial regeneration following ischemic injury in neonatal mouse and pig models. By investigating the single-cell spatial relationships and paracrine signaling of efficient, complete neovascularization and myocardial regeneration in neonatal mammals, the results of this study will inform future translational research efforts to reactivate key pathways in adults, which has the potential to benefit millions of patients with ischemic heart disease.

PI_NAMEs: ELDE, STEFAN  (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Acute;Adult;Advisory Committees;Affect;Aftercare;angiogenesis;Angiogenesis Modulating Agents;Animal Model;antibody conjugate;Antigens;Architecture;Arteries;Award;Bar Codes;Blood Vessels;Bone Marrow;Cardiac Myocytes;cell motility;Cell Physiology;cell type;Cells;chemokine;clinically significant;Complex;Coronary Artery Bypass;Cues;CXCR4 Receptors;Data;Detection;DNA;Endothelial Cells;Extracellular Matrix;Family suidae;Fellowship;Funding;Future;Goals;Grant;Heart;Heart failure;Human;imaging facilities;imaging platform;Immunofluorescence Microscopy;In Situ;indexing;Infarction;Inflammatory;Inflammatory Response;injured;Injury;insight;interest;ischemic injury;K-Series Research Career Programs;Lead;Life;Ligation;Link;Macrophage;Mammals;Mediator;Mentorship;migration;Modeling;monocyte;Morbidity - disease rate;mortality;mouse model;multidisciplinary;multiparametric imaging;Mus;Myocardial;Myocardial Infarction;Myocardial Ischemia;Myocardium;Natural regeneration;Neighborhoods;Neonatal;neonatal mice;neonatal period;neonate;neovascularization;neovasculature;new therapeutic target;Newborn Infant;novel;paracrine;Paracrine Communication;Pathologic;Pathway interactions;Patients;percutaneous coronary intervention;Perfusion;Persons;Phenotype;Physicians;porcine model;Positioning Attribute;Postdoctoral Fellow;Process;programs;Proliferating;Publishing;Recovery;recruit;regeneration potential;regenerative;Regenerative pathway;Regulatory Pathway;repaired;Research Training;Residual state;Resolution;revascularization;Role;Science;Scientist;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;spatial relationship;spatiotemporal;Stromal Cell-Derived Factor 1;Surgeon;Techniques;Therapeutic;Time;Tissues;Translational Research;United States National Institutes of Health;Ventricular Remodeling;Visualization;Work;wound healing

PROJECT_TITLE: Temporospatial Single-Cell Characterization of Angiogenesis and Myocardial Regeneration in Small and Large Mammals


ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative Myelodysplastic Syndromes (MDS) patients are considered to be accumulating mutations in the bone marrow before the onset of characteristic symptoms. DDX41 is one of the most frequently mutated genes in MDS and its functional role has not been fully understood. We will study the functional role of DDX41 in MDS and reveal its function in G4 accumulation.

PI_NAMEs: BI, HONGHAO  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Acute Myelocytic Leukemia;Affect;Alleles;Apoptosis;Binding Sites;Biogenesis;Biological Assay;Body Weight;Bone Marrow;CD34 gene;Cell Death;Cell Lineage;Cells;Characteristics;Cleavage Under Targets and Release Using Nuclease;Complete Blood Count;cytopenia;Data;Defect;Development;DNA Structure;Dysmyelopoietic Syndromes;Erythroblasts;Erythroid Cells;Erythropoiesis;experimental study;Flow Cytometry;Functional disorder;G-Quartets;Genes;Genome;Germ Lines;Germ-Line Mutation;Guanine;helicase;Hematologic Neoplasms;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Hematopoietic System;Human;In Vitro;in vivo;Knock-out;Knockout Mice;Lead;loss of function;Mediating;Modeling;Molecular;mouse model;Mus;Mutate;Mutation;novel;novel therapeutics;Pathogenesis;Pathway interactions;Patients;peripheral blood;Reporting;Research;response;Ribosomal Proteins;Ribosomes;Risk;Role;Site;Small Nucleolar RNA;Somatic Mutation;Spleen;Stress;Susceptibility Gene;Symptoms;targeted treatment;Technology;Testing;TP53 gene;Up-Regulation;Zebrafish

PROJECT_TITLE: The functional role of DDX41 in myelodysplastic syndromes


ADMINISTERING_IC: AT

ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Complementary and Integrative Health;Mental Health;Pediatric;Prevention

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative  Mindfulness-based intervention (MBI) may be an effective avenue for preventing adolescent mental health challenges; however, to maximize its potential requires a deeper understanding of processes underlying MBI efficacy. The proposed study will conduct a mechanistic investigation of the role of engagement (i.e., the degree of productive involvement in an activity) in adolescent MBI through examining the longitudinal, time-ordered change associations between engagement and target processes of MBI (e.g., emotion regulation and mindfulness), as well as integrating qualitative data with quantitative findings to identify facilitators and barriers to engagement. Findings may provide important directions for individuals involved in the development and delivery of MBI in terms of leveraging engagement to support adolescents in deriving maximal benefit from MBIs.

PI_NAMEs: MORAN, MEGAN JOY (contact)

PROGRAM_OFFICER_NAME: BAUMGARTNER, JENNIFER NICOLE

PROJECT_TERMS: Adolescence;Adolescent;adolescent health;adolescent health outcomes;adolescent mental health;age group;anxiety symptoms;arm;Behavioral;career;Chronic Disease;Cognitive;Cognitive Therapy;Communities;community based research;community collaboration;Data;design;Development;Dimensions;disability;disorder prevention;Distress;emotion regulation;Emotional;Equation;Ethics;experience;Fellowship;Foundations;Future;Goals;Health;improved;Individual;innovation;insight;Intervention;intervention effect;Interview;Investigation;Investments;Learning;lens;Life;life span;Measures;Mental Depression;Mental Health;Meta-Analysis;Methods;mindfulness;mindfulness intervention;Mindfulness Training;Modeling;National Center for Complementary and Integrative Health;National Research Service Awards;novel;Outcome;Parents;Personal Satisfaction;physical conditioning;Physiology;pre-doctoral;prevent;Prevention;Process;Productivity;programs;Randomized, Controlled Trials;Recurrence;Research;Research Support;Risk;Role;Sampling;Schools;Science;Scientist;Severities;skills;Stress;Symptoms;Testing;theories;Time;Training;Translational Research;Treatment Efficacy;Work

PROJECT_TITLE: The Role of Engagement in the Efficacy of Mindfulness Training for Adolescents


ADMINISTERING_IC: OD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Childhood Obesity;Dietary Supplements;Endocrine Disruptors;Nutrition;Obesity;Pediatric;Pregnancy;Prevention

ORG_CITY: Newark

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE Phthalates are common chemicals in the environment that can disrupt hormones and change how the body accumulates and stores fat. When pregnant women are exposed to these chemicals it may have negative impacts on their children, including increasing their risk for obesity. We will investigate how being exposed to these chemicals before birth is linked to childhood obesity, and whether certain diets can help prevent this.

PI_NAMEs: WEBB, MARY  (contact)

PROGRAM_OFFICER_NAME: MASH, CLAY

PROJECT_TERMS: 5 year old;Address;Adipocytes;Adolescent;Adult;Affect;aged;American;antioxidant enzyme;Antioxidants;Attenuated;Birth;Body Composition;Body mass index;catalase;Chemicals;Child;Child Health;Childhood;Chronic Disease;Committee Members;Consumption;Data;Development;Diet;dietary;Dietary Factors;dietary guidelines;Dietary Practices;early childhood;early pregnancy;Elements;Endocrine Disruptors;Environment;Environmental Epidemiology;Environmental Exposure;Epidemic;Epidemiology;Exposure to;Fatty acid glycerol esters;Fishes;Food;fruits and vegetables;Generations;Geography;Growth;Health;Healthy Eating;Hormones;Human Resources;indexing;Infant;Inflammation;insight;Intervention;Investigation;Life;Link;Mental Health;Metabolic Pathway;Metabolism;Methodology;modifiable risk;mother nutrition;Mothers;North America;novel;nutrition;nutritional epidemiology;Obesity;obesity development;obesity in children;obesity prevention;obesity risk;obesogen;obesogenic;Omega-3 Fatty Acids;Outcome;Overweight;overweight child;Oxidative Stress;Pathway interactions;Pattern;Pediatric cohort;phthalates;Physical activity;physical conditioning;Physiology;Population;Positioning Attribute;Predisposition;Pregnancy;Pregnant Women;prenatal;prenatal exposure;prenatal influence;prevent;programs;Public Health;Recommendation;Reporting;Research;Risk;Risk Factors;Sample Size;saturated fat;Source;Statistical Methods;Structure;study population;success;Superoxide Dismutase;United States;Vulnerable Populations;Work

PROJECT_TITLE: Influences of Prenatal Phthalate Exposure on Early Childhood Overweight/Obesity and Potentially Protective Dietary Strategies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EPH-F (50)]


NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative The goal of this work is to understand function of specific cell types in cortical microcircuits, focusing on inhibitory interneurons, and similarities and differences in their local network impacts in sensory and association areas of cortex. Two-photon imaging of calcium activity is used to monitor the responses of hundreds of genetically labeled inhibitory and excitatory neurons, while subjects perform a sound localization task in virtual reality. These experiments will lead to the development of testable models of the local circuit mechanisms underlying flexible information processing across cortex, with relevance for brain disorders with altered cognitive flexibility, such as schizophrenia.

PI_NAMEs: RUNYAN, CAROLINE ANNE (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Anatomy;Area;association cortex;Auditory;Auditory area;Axon;behavior influence;Brain;Brain Diseases;Calcium;cell type;Cells;Cerebral cortex;Cognitive;Cortical Column;Development;Disinhibition;Dyes;Electrophysiology (science);excitatory neuron;experimental study;flexibility;Gene Expression Profile;Goals;hippocampal pyramidal neuron;Image;Individual;information processing;inhibitory neuron;innovation;Interneurons;Label;Lead;Location;Logic;Maps;Measures;Modeling;Molecular;Monitor;Morphology;Mus;neural;Neurons;optogenetics;Parietal Lobe;Pattern;Performance;Population;Property;response;Role;Schizophrenia;Sensory;sensory cortex;sensory integration;sensory stimulus;Shapes;Signal Transduction;Sound Localization;Structure;Synapses;Time;two-photon;virtual reality;Work

PROJECT_TITLE: The functional logic of local circuits in auditory and parietal cortices

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_DEPT: PEDIATRICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE This project will study the complex factors shaping neurodevelopment in a diverse group of children with T1D and will help identify critical targets for intervention to promote optimal brain and cognitive outcomes.

PI_NAMEs: ARBELAEZ, ANA MARIA  (contact);HERSHEY, TAMARA G

PROGRAM_OFFICER_NAME: WOO, THERESA TESLOVICH

PROJECT_TERMS: Address;Adult;Age;Age of Onset;Attention;Autoimmune;Brain;brain health;brain magnetic resonance imaging;Child;clinically significant;Cognition;Cognitive;cognitive function;cognitive performance;cognitive testing;Communities;community engagement;comorbidity;Complex;Continuous Glucose Monitor;critical period;Crystallization;Data;data collection methodology;design;Diabetes Mellitus;Diagnosis;Ecological momentary assessment;Eligibility Determination;ethnic minority;Ethnic Origin;Exposure to;Face;Family;Family member;fitbit;follow-up;glycemic control;Hippocampus;Home;Hyperglycemia;Hypoglycemia;Impaired cognition;Individual;Insulin-Dependent Diabetes Mellitus;Intelligence;Intervention;Leadership;Life;Literature;Longitudinal Studies;Measures;meetings;Metabolic;Methodology;Methods;middle age;modifiable risk;Moods;neighborhood disadvantage;Neighborhood Health Center;Neurobiology;Neurocognitive;Neurocognitive Deficit;neurodevelopment;Newly Diagnosed;novel;Obesity;older adult;Outcome;Patients;Population Heterogeneity;Predictive Factor;Predisposition;prepuberty;Prevention;primary outcome;processing speed;Productivity;protective factors;Protocols documentation;Puberty;Race;racial minority;recruit;Research;response;Risk;Risk Factors;risk mitigation;rural underserved;secondary outcome;sex;Shapes;Short-Term Memory;Siblings;Site;Sleep;social health determinants;socioeconomic disadvantage;socioeconomics;Structure;Technology;Testing;Time;Translational Research;United States National Institutes of Health;Universities;Washington;Work;Youth

PROJECT_TITLE: UNITED: Understanding neurocognitive outcomes in Type 1 diabetes: Modifiable risk and protective factors in diverse youth

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-1 (M3)]


NIH_SPENDING_CATS: Aging;Chronic Pain;Interstitial Cystitis;Neurosciences;Pain Research;Urologic Diseases

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: DIGNIFY THERAPEUTICS, LLC

ORG_STATE: NC

PHR: Narrative  Urinary incontinence (UI) and symptoms of overactive bladder (OAB) become more prevalent with age, and because the impact on the elderly and their caregivers makes it difficult to continue at-home care, UI is a top reason for institutionalizing the elderly. More than half of nursing home residents have UI and over ¾ of those with dementia have UI. The current application proposes to develop new formulations of drugs that are instilled into the bladder (intravesical delivery) and produce long-term relief of symptoms (> 3 months) in patients who are refractory to current therapies.

PI_NAMEs: ZHANG, QIAOJUAN  (contact)

PROGRAM_OFFICER_NAME: FOX, JENNIFER THERESA

PROJECT_TERMS: Absence of pain sensation;absorption;Accidents;Action Potentials;Acute;Age;Aging;Agonist;Amaze;analog;Anesthesia procedures;antagonist;Basic Science;Bladder;Capsaicin;Caregivers;Catheterization;Cations;Clinic Visits;Clinical;Clinical Research;Clinical Sciences;Clinical Treatment;Cystitis;Data;Dementia;desensitization;Dose;Drug Formulations;Drug Interactions;Drug Targeting;drug testing;Elderly;Encapsulated;Ensure;Ethanol;Fatty Acids;Formulation;Funding;Hour;Hydrophobicity;Hyperthermia;in vivo;Injections;insight;Institutionalization;internal control;Intestines;intravesical;Intravesical Instillation;irritation;Kinetics;Laboratories;lead candidate;lipophilicity;liposomal formulation;Liposomes;Literature;Mentors;Metabolism;Methods;Modeling;Natural regeneration;Nerve;Neurons;Neuropathy;Nociception;Nociceptive Stimulus;Nociceptors;novel;novel therapeutics;Nursing Homes;Organic solvent product;Orthopedics;Overactive Bladder;Pain;pain sensation;patient home care;patient population;Patients;Pelvis;Peripheral;Pharmaceutical Preparations;Phase;Plasma;Play;Population;Postdoctoral Fellow;pressure;prevent;Property;Protocols documentation;Rapid screening;Rattus;receptor;reduce symptoms;Reference Standards;Refractory;Reproducibility of Results;Research;Resiniferatoxin;response;Role;Saline;side effect;Site;Small Business Innovation Research Grant;Solubility;Stigmatization;Stimulus;Supervision;Symptoms;Tail;Techniques;Testing;Therapeutic Effect;Topical application;TRPV1 gene;United States National Institutes of Health;Urinary Incontinence;Viscera;Visceral;voltage

PROJECT_TITLE: Novel treatment for urinary incontinence and overactive bladder symptoms in the elderly