ORG_STATE: PA

PHR: Quantitative PET biomarker imaging promises to play a significant role in delivering precision medicine for cancer patients, since it can provide accurate biomarker uptake measurements that are necessary for tumor characterization as well as measuring changes in response to therapy. While PET images acquired during routine 18F-FDG imaging are highly accurate, it is challenging to maintain the same performance when imaging large patients (increased multiple scatter, low counts, and reduced tail-fitting region), in situations where few coincidence events are collected (e.g. imaging at low injected activity levels for repeat scans or imaging tracers with a low positron yield), or imaging new radiotracers using isotopes emitting prompt gamma. For PET to fulfill its role in this era, quantification accuracy of PET images needs to be maintained over a large range of data acquisition protocols, where the quantification challenge is the accuracy of the scatter and background estimation method that is used to compensate (correct) for the bias present in the data due to scattered coincidences and prompt gamma events.

PI_NAMEs: SURTI, SULEMAN  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: 90Y;Adopted;Algorithms;Area;attenuation;Beds;Biological Markers;Brain;Breast;Calibration;cancer imaging;Cancer Patient;Cardiac;Childhood;Clinical;Clinical Data;clinical imaging;clinical practice;Clinical Research;Compensation;Data;data acquisition;Dedications;Development;Disadvantaged;Disease;Distributional Activity;Dose;Environment;Estimation Techniques;Evaluation;Event;fluorodeoxyglucose;Geometry;Goals;heart imaging;Image;image reconstruction;imaging biomarker;improved;individual patient;Isotopes;Knowledge;Magnetic Resonance Imaging;Maps;Measurement;Measures;Methodology;Methods;Modeling;Molecular Target;Monitor;Monte Carlo Method;Motion;Oncology;Organ;Patients;Performance;PET/CT scan;Photons;Play;Positron;Positron-Emission Tomography;precision medicine;precision oncology;Predisposition;Process;Protocols documentation;prototype;quantitative imaging;Radioisotopes;radiotracer;Research;Resources;Role;Scanning;Shapes;simulation;spectral energy;System;Tail;targeted cancer therapy;targeted treatment;Techniques;Testing;theranostics;Tracer;transmission process;treatment response;tumor;uptake;Vendor;Work;X-Ray Computed Tomography

PROJECT_TITLE: Data Driven Background Estimation in PET

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ITD-Q (90)]


ADMINISTERING_IC: ES

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: CHICAGO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE Heavy metal pollution by arsenic (iAs), Cadmium (Cd) and lead (Pb) disproportionally affects low income and historically underappreciated communities nationally and internationally. We found that these metals alone and in combination, at doses much lower than the World Health Organization (WHO) recommended limits, promote an increase in the generation of reactive oxygen species by ER+/PR+ breast cancer cell mitochondria leading to chromatin oxidative remodeling in the nucleus and the progression of the disease to multi-drug resistant metastasis. This project proposes the development of new and FDA-approved pharmacologic nucleus- and mitochondria-targeted antioxidants as chromatin protective agents to spare H3.1 from oxidation and prevent heavy metal-induced worsening of breast cancer for patients impacted by socioeconomic and environmental health disparities.

PI_NAMEs: BONINI, MARCELO G. (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: acquired drug resistance;Affect;Amino Acids;Antioxidants;Area;Arsenic;Automobile Driving;Binding;Biological;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Patient;breast cancer progression;Cadmium;cancer cell;cancer drug resistance;catalase;Cell Nucleus;Cell Reprogramming;Cells;Chemoresistance;chemotherapy;Chromatin;chromatin remodeling;Clinical;Communities;cost;Cysteine;cytokine;Data;Development;Disease;Disease Progression;disparities in morbidity;Dose;Environmental Health;environmental health disparity;Epigenetic Process;epithelial to mesenchymal transition;Epithelium;Estrogen receptor positive;Excision;Exposure to;FDA approved;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic Transcription;Genomics;health inequalities;Heavy Metals;Heterochromatin;Histone H3;Histones;Hydrogen Peroxide;improved;in vivo;International;Interruption;Intervention;Lead;Licensing;Link;Liquid substance;Low income;Low Income Population;Malignant Breast Neoplasm;Mammary Neoplasms;Mesenchymal;Metabolic;Metabolism;Metal exposure;Metals;Metastatic breast cancer;Metastatic/Recurrent;mimetics;Mitochondria;mortality;Multi-Drug Resistance;Mus;mutant;Neoplasm Metastasis;neoplastic cell;novel;Nuclear;Nucleic Acid Regulatory Sequences;Nucleosomes;Organoids;oxidation;Oxidation-Reduction;Oxidative Stress;Pathway interactions;Patients;pharmacologic;Phenotype;Play;pollutant;Pollution;Post-Translational Protein Processing;prevent;Primary Neoplasm;Process;Production;programs;Protective Agents;Reactive Oxygen Species;Recommendation;Regulation;Resistance;Role;Selective Estrogen Receptor Modulators;Serine;socioeconomics;stemness;Tamoxifen;Testing;Therapeutic;therapy outcome;therapy resistant;transcription factor;Transforming Growth Factor beta;Treatment Efficacy;tumor metabolism;tumor progression;tumor xenograft;Variant;World Health Organization;Xenograft Model

PROJECT_TITLE: H3 histone oxidation is a new posttranslational modification linking heavy metal-induced metabolic changes and oncegenic epigenetic reprogramming

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Heart Disease;Kidney Disease;Organ Transplantation;Transplantation

ORG_CITY: Aurora

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Long-term allograft function in kidney transplant recipients (KTRs) remain suboptimal, and graft failure causes significant morbidity and mortality, with cardiovascular disease being the leading cause of death in KTRs and the most common cause of death with a functioning graft. Sodium-glucose cotransporter 2 (SGLT2) inhibitors safely lower cardiovascular and kidney disease risk in the non-transplant population, yet data in KTRs are lacking. This clinical trial seeks to establish the efficacy and safety of dapagliflozin, a SGLT2 inhibitor, for improving cardiovascular and kidney graft function in adult KTRs with type 2 diabetes and post-transplant diabetes, and to leverage innovate translational methods to define the underlying mechanisms of action.

PI_NAMEs: BJORNSTAD, PETTER ;KENDRICK, JESSICA B (contact)

PROGRAM_OFFICER_NAME: ABBOTT, KEVIN C

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Adherence;Adult;Albumins;Albuminuria;Allografting;Aorta;arterial stiffness;Attenuated;attenuation;Biology;Biopsy;Blood Vessels;Cardiac;cardiac magnetic resonance imaging;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular Physiology;Cardiovascular system;cardiovascular transplantation;Cause of Death;Cessation of life;Characteristics;Chronic Kidney Failure;clinical phenotype;Clinical Trials;Complex;Continuous Glucose Monitor;Creatinine;Data;Diabetes Mellitus;diabetic;disorder risk;Double-Blind Method;Event;Exclusion;experience;Feedback;Fibrosis;FRAP1 gene;General Population;Genitourinary System Infection;Glomerular Filtration Rate;Glucose;graft failure;graft function;Graft Rejection;heart function;Hypoglycemic Agents;Hypoxia;Immune response;improved;inhibitor;innovation;insight;interest;interstitial;Kidney;kidney allograft;kidney biopsy;Kidney Diseases;Kidney Failure;kidney fibrosis;Kidney Transplantation;loss of function;Magnetic Resonance Imaging;Metabolic;Metabolism;Methods;Molecular;Molecular Profiling;Morbidity - disease rate;morphometry;mortality;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Outcome;Participant;Patients;Perfusion;Peripheral;Pharmaceutical Preparations;Phenotype;Physiologic pulse;Placebo Control;Placebos;Play;Population;post-transplant;preservation;pressure;primary outcome;protective effect;Randomized;Randomized, Controlled Trials;Renal function;Renal tubule structure;restoration;Risk;Safety;Signal Transduction;single-cell RNA sequencing;Sodium;Specific qualifier value;standard of care;Structure;symporter;Testing;Tissues;Transplant Recipients;Urinary tract infection;Urine

PROJECT_TITLE: Efficacy and Mechanisms of Dapagliflozin in Promoting Kidney Function and Cardiovascular Health in Kidney Transplant Recipients

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: NARRATIVE The basal-like subtype of PDAC associates with resistance to treatment and poor patient outcome. Our study will provide mechanistic insights into the molecular mechanism by which intratumoral hypoxia promotes the basal-like state through the suppression of the histone demethylase KDM8. Our findings will likely uncover novel approaches to reverse hypoxia-induced basal-like state while promoting the treatment-sensitive classical subtype.

PI_NAMEs: CHIOU, SHIN-HENG  (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Address;Affinity;Binding;cancer cell;Cell Line;Cells;Chromatin;chromatin immunoprecipitation;clinically relevant;Complex;Coupled;demethylation;Development;disorder subtype;DNA Sequence Alteration;Epigenetic Process;Epithelium;experimental study;Gene Expression;Gene Expression Profiling;Gene Silencing;Genes;Genetic Engineering;genetic signature;Goals;Histologic;histone demethylase;Histones;Human;Hypoxia;in vivo;innovation;insight;Invaded;Link;Lysine;Malignant neoplasm of pancreas;Malignant Neoplasms;malignant phenotype;Mediating;Mesenchymal;Methylation;migration;Molecular;molecular subtypes;Morphology;mouse model;Mus;Mutation;Neoplasm Metastasis;normoxia;novel;novel strategies;novel therapeutic intervention;Oxygen;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Patient-Focused Outcomes;Patients;Phenotype;Play;Polycomb;Positioning Attribute;programs;Property;Regulation;Resistance;Role;stemness;Therapeutic;transcriptome;tumor microenvironment;Up-Regulation

PROJECT_TITLE: Elucidation of hypoxia-induced metastatic reprogramming through the regulation of KDM8 function in pancreatic cancer

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CAMBRIDGE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative With age, the body’s ability to repair and regenerate tissues gradually decline. Using hair follicle stem cells (HFSCs) as a model for studying stem cell changes during aging, we will identify genes that can functionally rejuvenate old HFSCs or drive HFSC aging. These results are not only important for the mechanistic understanding of HFSC aging, but may also inform innovative therapeutic solutions to halt or revert age-related decline seen with stem cells.

PI_NAMEs: HSU, YA-CHIEH  (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Address;adeno-associated viral vector;Adrenal Glands;Adrenalectomy;Affect;Age;age acceleration;age related;age related changes;age related decline;aged;Aging;Automobile Driving;Behavior;Biological Assay;C57BL/6 Mouse;Candidate Disease Gene;Cells;Chromatin;Chronic stress;combat;Communities;Corticosterone;cost;Data;Defect;Dependovirus;Dermal;differential expression;Excision;experience;Experimental Genetics;experimental study;extracellular;Fibroblasts;Foundations;Future;Gene Expression;gene function;Genes;Genetic;genetic manipulation;Genetic Models;genetic testing;Growth;Hair;Hair follicle structure;hair regeneration;Immunofluorescence Immunologic;in vivo;innovation;insight;Knockout Mice;Knowledge;Mammals;Measures;Mediating;Methods;Molecular;molecular phenotype;Mus;National Institute on Aging;Natural regeneration;Nature;old mice;overexpression;Pathway interactions;Phase;Phenotype;Play;Process;Regenerative capacity;Rejuvenation;repaired;Research;Resolution;Rest;Rodent;Route;Signal Transduction;Signaling Molecule;Skin;Skin Aging;Solid;Speed;stem cell aging;stem cell function;stem cells;Stereotyping;Stress;Study models;Techniques;Testing;Therapeutic;therapeutic target;therapy development;tissue regeneration;tongue papilla;tool;transcriptome;transcriptome sequencing;Viral;Virus;Wild Type Mouse;Work

PROJECT_TITLE: Aging and Rejuvenation of Skin Stem Cells

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine

ORG_CITY: MILWAUKEE

ORG_DEPT: PEDIATRICS

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE This proposal is rooted in the fundamental cell biology underlying heart muscle cell division and expansion during heart development, as well as its impact on ischemic heart repair. We will investigate the cellular mechanisms and their components that direct the organization of the mitotic apparatus, a requirement for heart muscle cell division, and how they affect remuscularization post ischemic heart injury. The current incomplete understanding of how division is repressed in adult mammalian cardiomyocytes constitutes an enormous obstacle for designing heart regeneration strategies, and this research will help to elucidate the mechanistic basis of mitotic regulation at key developmental stages, and after cardiac injury.

PI_NAMEs: HAN, LU  (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Actomyosin;Adolescent;Adult;Affect;Bypass;Cardiac Myocytes;cardiac regeneration;cardiac repair;cardiogenesis;Cell Cycle;Cell division;Cells;Cellular biology;Chromosome Segregation;Cicatrix;Cleavage Under Targets and Release Using Nuclease;Cytoskeletal Modeling;Cytoskeleton;Data;daughter cell;design;Development;Embryonic Development;Environment;Failure;Generations;Goals;Heart;Heart failure;Heart Injuries;human induced pluripotent stem cells;improved;induced pluripotent stem cell;injured;Injury;Ischemia;ischemic injury;lamin B2;Mediating;Methods;Microtubules;Mitosis;Mitotic;Mitotic spindle;Mitotic Spindle Apparatus;Molecular;Mus;Muscle;Myocardial;Myocardial Infarction;Myocardial Ischemia;Natural regeneration;Neonatal;novel;Nuclear Lamina;overexpression;Patients;permissiveness;Polyploidy;postnatal;postnatal development;prevent;Process;Proliferating;Proteins;Publishing;regenerative;Regulation;Reporter;Repression;Research;single-cell RNA sequencing;Testing;Therapeutic;Time;Transcription Repressor;Ventricular Remodeling;Work

PROJECT_TITLE: Eliciting Cardiomyocyte Proliferation by Un-blocking Mitotic Transit

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Substance Misuse;Tobacco

ORG_CITY: EUGENE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: PROJECT NARRATIVE How people flexibly control ongoing movements is a critical feature of healthy human behavior. Current approaches for studying these behaviors have used motor tasks with limitations, and neuroscientific approaches that are unable to reveal contributions of cortical and subcortical brain regions with high spatiotemporal resolution. We aim to overcome these limitations by using a novel motor control task in combination with an invasive and non-invasive brain recording techniques, subcortical brain stimulation, and validated rating scales.

PI_NAMEs: SWANN, NICOLE CHRISTIANE (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: addiction;Addictive Behavior;Address;Area;Attention Deficit Disorder;Attention deficit hyperactivity disorder;Behavior;Behavior Control;behavior measurement;Behavioral;behavioral study;Brain;Brain region;Clinical;clinically relevant;Cognition;Cognitive;cognitive process;cohort;Data;Deep Brain Stimulation;design;Diagnostic;Disease;Electroencephalography;Electrophysiology (science);Epilepsy;executive function;Exhibits;experimental study;flexibility;Globus Pallidus;Human;Impaired cognition;Impairment;Implanted Electrodes;Impulsivity;Individual;Interruption;Investigation;Laboratories;Life;Link;Measures;Minority;Modeling;Monitor;Motor;motor control;Motor output;Movement;neural network;Neural Pathways;neurophysiology;Nicotine Dependence;nicotine user;novel;Obsessive-Compulsive Disorder;Organism;Parkinson Disease;Participant;Pathologic;Pathway interactions;Patients;Pattern;Performance;Persons;Physiological Processes;Population;Process;recruit;Research;Resolution;response;Role;Scalp structure;Signal Transduction;Smoker;spatiotemporal;Specificity;Stimulus;Structure of subthalamic nucleus;Substance abuse problem;Techniques;Testing;Time;Walking;Work

PROJECT_TITLE: Cortical and subcortical neurophysiology in terminating movement

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: This study addresses middle-aged and older adult veterans with slow gait speed. Slow walking speed is a frequent patient complaint and is associated with bad health outcomes including disability and death. Physical therapy (PT) care is the usual treatment for older adults with slow gait speed, but the optimal model of PT care is not known. Outside of the VA, we developed Live Long Walk Strong (LLWS) which is a program of PT care that builds upon our research identifying new treatments with greater benefit than usual care. We must confirm that LLWS can benefit Veterans beginning in midlife. We intend to conduct a study of LLLWS among community dwelling Veterans in comparison to usual care. We will evaluate the benefits that LLWS provides on walking skills and the qualities that lead to walking skill improvements. We will also evaluate if the benefits of LLWS last up to 16 weeks after treatment ends. If successful, this study will establish LLWS as a treatment targeting health and functional independence, which can be provided in a variety of VA care settings.

PI_NAMEs: BEAN, JONATHAN F (contact)

PROJECT_TERMS: Accounting;Address;Advocate;Aftercare;Age;aged;Ambulatory Care Facilities;Boston;Caring;Cessation of life;Clinical;Clinical Trials;cohort;Communities;comorbidity;design;disability;Disease;efficacious treatment;Elderly;Exercise;falls;functional independence;Funding;Future;Gait;Gait speed;Gender;Goals;Health;Health Care Costs;health care settings;Healthcare Systems;High Prevalence;Hospitalization;Impaired cognition;Impairment;improved;improved mobility;innovation;Lead;Leg;Link;Mediating;middle age;Mobility decline;Modeling;Muscle;new therapeutic target;novel therapeutics;older adult;Outcome;Outpatients;Pain;Patients;Performance;Phase;Physical activity;physical model;Physical therapy;Prevalence;Preventive care;primary care patient;primary outcome;programs;Randomized;Randomized Controlled Clinical Trials;Readiness;Recording of previous events;recruit;rehabilitation science;Rehabilitation therapy;rehabilitative care;Research;Risk;secondary outcome;Self Efficacy;skills;Speed;standard care;therapeutic target;treatment as usual;treatment duration;treatment effect;United States National Institutes of Health;Veterans;Waiting Lists;Walking;walking speed;Work

PROJECT_TITLE: The Live Long Walk Strong rehabilitation program: What features improve mobility skills?

STUDY_SECTION_NAME: Chronic Medical Conditions & Aging[RRD6]


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: RALEIGH

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: PROJECT NARRATIVE Cell migration directed by external gradients of soluble and matrix-associated ligands, and of tissue stiffness, is encountered in various physiological and natural settings and is a primary means by which cells are instructed to move within and between tissues. We propose to study the molecular mechanisms underlying directed migration of mesenchymal cells using a multi-disciplinary approach involving molecular perturbations, microfluidics, cutting-edge microscopy and image analysis. These studies will directly contribute to our understanding the physiological basis of disease states such as tumor metastasis, fibrosis and cardiovascular disease, as well as our understanding of physiological processes such as wound healing.

PI_NAMEs: HAUGH, JASON M. (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Acceleration;Actins;Affect;Biological Assay;Cardiovascular Diseases;Cardiovascular system;cell behavior;cell motility;Cells;Cellular biology;Chemicals;Chemotactic Factors;Chemotaxis;combinatorial;Complex;Cues;Cytoskeleton;density;Disease;Disseminated Malignant Neoplasm;Elements;Engineering;Extracellular Matrix;F-Actin;Feedback;Fibroblasts;Fibrosis;Generations;Image Analysis;Immobilization;in vivo;Integrins;interdisciplinary approach;Invaded;Leukocytes;Ligands;link protein;Location;Mediating;Mesenchymal;Microfluidics;Microscopy;migration;Molecular;Movement;Myosin Regulatory Light Chains;Neoplasm Metastasis;non-muscle myosin;Nonmuscle Myosin Type IIA;Pathologic;Pathway interactions;Phospholipase C;Phosphorylation;Physiological;Physiological Processes;Platelet-Derived Growth Factor;Play;polymerization;Polymers;Process;Productivity;Protein Kinase C;Regulation;Regulatory Pathway;Role;Shapes;Signal Pathway;Signal Transduction;Signaling Protein;Surface;synergism;Testing;Time;Tissues;tumor;Variant;Work;wound;wound healing

PROJECT_TITLE: Multi-cue Guidance of Mesenchymal Cell Migration

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Neurosciences;Rare Diseases;Tuberous Sclerosis

ORG_CITY: PITTSBURGH

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Alternative polyadenylation (APA), which expands the complexity of brain transcriptome and proteome, is critical for normal brain function and is dysregulated in many neurological disorders. The proposed study will advance our knowledge in understanding how APA maintains proper neurological functions and how abnormal APA contribute to the pathogenesis of tuberous sclerosis and other “mTORopathies”. Knowledge obtained from the proposed study will facilitate the development of novel diagnostic and therapeutic options for a broad range of neurological disorders.

PI_NAMEs: HWANG, HUN-WAY  (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: 3' Untranslated Regions;Acute;Address;adeno-associated viral vector;Affect;Astrocytes;bioinformatics pipeline;Biological Process;Brain;brain cell;Brain Diseases;Cell Line;cell type;Cells;Clinical Management;Complex;Cultured Cells;Dependovirus;design;Development;disease model;excitatory neuron;expression vector;FRAP1 gene;Future;Goals;in vivo;Individual;Informatics;inhibitor;inhibitory neuron;insight;intravenous injection;Knock-out;Knockout Mice;Knowledge;Knowledge Management;Libraries;Literature;LoxP-flanked allele;Messenger RNA;Methods;MicroRNAs;Molecular;mouse model;mTORopathies;Mus;Nervous System Disorder;Nervous System Physiology;Neuroglia;Neurologic Symptoms;Neurons;new technology;novel;novel diagnostics;novel therapeutics;Outcome;Pathogenesis;Pathway interactions;Phenotype;Polyadenylation;Pre-mRNA Polyadenylation Factor;preservation;Production;protein expression;Protein Isoforms;Protein Truncation;Proteins;Proteome;Regulation;Resources;response;RNA-Binding Proteins;Role;Signal Transduction;Sirolimus;Site;Specificity;Technology;Testing;Time;tool;transcriptome;transcriptome sequencing;TSC1 gene;Tuberous Sclerosis;Validation;vector;Wild Type Mouse;Work

PROJECT_TITLE: Regulation and biological functions of mRNA Alternative Polyadenylation in the Brain

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Cancer;Digestive Diseases;Nanotechnology;Orphan Drug;Ovarian Cancer;Pancreatic Cancer;Rare Diseases;Women's Health Research

ORG_CITY: CORVALLIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: OREGON STATE UNIVERSITY

PHR: PROJECT NARRATIVE Magnetic hyperthermia is a highly promising therapy for various cancers based on the nanoparticle’s capacity to generate intratumoral heat in the presence of an external magnetic field. However, it is currently limited to the treatment of relatively accessible tumors because the required therapeutic temperatures can only be achieved by direct intratumoral injection of conventional magnetic nanoparticles. We propose novel magnetic nanoparticles that can efficiently accumulate in deep-seated primary and metastatic tumors following systemic injection and generate desirable intratumoral temperatures upon exposure to a magnetic field.

PI_NAMEs: TARATULA, OLEH  (contact)

PROGRAM_OFFICER_NAME: AVULA, LEELA RANI

PROJECT_TERMS: Address;Animal Model;Animals;anti-cancer research;Biodistribution;biomaterial compatibility;cancer cell;cancer therapy;Cell Death Induction;chemotherapy;Chemotherapy and/or radiation;Clinical;Clinical Research;clinical translation;clinically relevant;Cobalt;Data;Desmoplastic;Disseminated Malignant Neoplasm;Dose;efficacy evaluation;Encapsulated;Exposure to;Goals;Heating;Human;Hyperthermia;Implant;improved;In Situ;Injections;intraperitoneal;Intravenous;intravenous administration;intravenous injection;invention;Ions;iron oxide;iron oxide nanoparticle;magnetic field;Magnetic nanoparticles;Magnetism;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;Manganese;Mediating;Metals;Modality;Modeling;multidisciplinary;Mus;nanocluster;nanomedicine;nanoparticle;nanoparticle delivery;nanopolymer;Neoplasm Metastasis;novel;ovarian neoplasm;pancreatic cancer cells;pancreatic cancer model;Pancreatic Ductal Adenocarcinoma;pancreatic neoplasm;Peptides;preclinical study;Predisposition;preservation;Primary Neoplasm;Rattus;Reproducibility;Research;Research Personnel;Rodent;Shapes;Site;subcutaneous;Surface;targeted delivery;Technology;Temperature;Testing;Therapeutic;Tissues;Toxic effect;translational potential;Treatment Efficacy;tumor;tumor growth;tumor specificity;validation studies;Xenograft procedure;Zinc

PROJECT_TITLE: Intravascular Delivery of Nanoclusters for Treatment of Deep-Seated Cancers with Magnetic Hyperthermia

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


NIH_SPENDING_CATS: Lung;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Narrative These studies will allow development of a transplantation method, an important tool to study the role of progenitor cells in repairing damaged lung tissue. We will also discover factors that can stimulate airway and alveolar repair. Our proposed studies will provide new ways to understand and treat lung disease.

PI_NAMEs: KIM, CARLA F. (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: 3-Dimensional;Adult;Alveolar;Biological Assay;Biological Process;Biology;Cataloging;Cell Communication;cell type;Cells;Coculture Techniques;Communities;Development;Endothelial Cells;Environment;epithelial stem cell;Focus Groups;Homeostasis;Human;injury and repair;Lung;Lung Diseases;lung injury;Malignant neoplasm of lung;Mesenchymal;Methods;Modeling;Molecular;mouse model;novel strategies;Organoids;paracrine;progenitor;programs;Regenerative Medicine;repaired;Research;response to injury;Role;Signal Transduction;single-cell RNA sequencing;stem cell biology;Stem cell transplant;stem cells;Structure;Structure of parenchyma of lung;Supporting Cell;System;Techniques;Therapeutic Intervention;Therapeutic Uses;tool;Transplantation

PROJECT_TITLE: Cell-cell interactions governing lung epithelial progenitor cells


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: PROJECT NARRATIVE Cerebral arteries are critical for proper function of the brain. The proposed research aims to study the associations between changes in cerebral arteries and the progression of Alzheimer’s disease as well as cognitive impairment. Such understandings may lead to the discovery of new treatment options for Alzheimer's disease.

PI_NAMEs: STEIN, THOR ;ZAIA, JOSEPH ;ZHANG, YANHANG KATHERINE (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: abeta accumulation;Abeta clearance;abeta deposition;Affect;Age;Alzheimer's Disease;Alzheimer's disease pathology;anterior cerebral artery;Arteries;Atrophic;Attention;Biological Markers;Biology;biomechanical test;Biomechanics;Birefringence;Blood - brain barrier anatomy;Blood Vessels;Brain;brain metabolism;brain tissue;Cause of Death;Cells;cerebral artery;cerebrovascular;Cerebrovascular Disorders;Cerebrovascular system;Cerebrum;Cessation of life;Clinical;Cognition;Cognitive;Collagen;Consensus;cost;Data Set;Dementia;design;Development;Diagnosis;Diagnostic;Economic Burden;Elasticity;Episodic memory;Evaluation;executive function;Extracellular Matrix;Fiber;frontal lobe;Funding;glycoproteomics;Goals;Homeostasis;Human;Immunohistochemistry;Impaired cognition;Injury;Intervention;Language;Life;life span;Mass Spectrum Analysis;Measures;Metabolism;Microcirculation;Microscopy;mild cognitive impairment;Modeling;Molecular Structure;multidisciplinary;multiphoton imaging;Myelin;Nerve Degeneration;Neurodegenerative Disorders;Neurologic;Neurons;neuropathology;Neuropsychological Tests;optical imaging;Outcome;Pathogenesis;Pathologic;Pathology;performance tests;Perfusion;Persons;Play;Population;pre-clinical;Predisposition;pressure;Property;Pulse Pressure;Research;Resources;Role;sex;Smooth Muscle Myocytes;Societies;Stress;Structure;Symptoms;tau Proteins;Temporal Lobe;Testing;United States;Vascular Diseases;Vascular remodeling;Visit;Visuospatial

PROJECT_TITLE: Cerebrovascular Remodeling and Neurodegenerative Changes in Alzheimer's Disease


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative: Public Health Relevance Section  A combined chemical and genetics-based approach is being developed for the discovery of highly domain selective bromodomain inhibitor molecules for the epigenetic proteins BRD4 and BPTF. Inhibiting transcription factor function mediated by epigenetic proteins is a powerful but challenging approach for controlling disease. Our newly developed chemical probes and structural biology approaches described here will help establish distinct molecular mechanisms used by bromodomain-containing proteins for transcriptional regulation and for ultimately treating disease.

PI_NAMEs: POMERANTZ, WILLIAM CHARLES KRAUSE (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: Address;Affinity;Autophagocytosis;Biology;biophysical techniques;Bromodomain;Cells;Chemicals;Chromatin;Complex;Development;Disease;disorder control;DNA;drug discovery;Drug Targeting;Epigenetic Process;epigenetic therapy;epigenome;Fluorine;Gene Expression Regulation;Genetic;Genetic Transcription;Goals;Health;Human;improved;Inflammation;inhibitor;innovation;Lead;Ligand Binding;Malignant Neoplasms;Mediating;Methodology;Methods;millisecond;Molecular;molecular assembly/self assembly;Nature;next generation;novel;Nucleosomes;Nylons;Pharmaceutical Preparations;programs;Protein Isoforms;protein protein interaction;Proteins;public health relevance;Rapid screening;Reader;Research;Role;small molecule;structural biology;Tertiary Protein Structure;tool;transcription factor;Transcriptional Regulation;tumor progression

PROJECT_TITLE: Chemical Probe Development for Epigenetic Complexes Enabled by Protein-Observed 19F NMR

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: NEW HAVEN

ORG_DEPT: GENETICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE All information transmitted from one generation to the next passes through the sperm and egg. This proposal seeks to evaluate the information transmitted through sperm that is not directly encoded in DNA. These experiments will provide a new framework for understanding male infertility and for how disease susceptibility is transmitted across generations.

PI_NAMEs: LESCH, BLUMA J (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Address;Adult;Affect;Area;Attention;Biological;Cell Nucleus;Chemicals;Chromatin;conditional knockout;Data;demethylation;Development;Diabetes Mellitus;Disease;Disease susceptibility;DNA;DNA Methylation;egg;Embryo;Environment;Epidemiology;Epigenetic Process;Etiology;Event;experimental study;Fertility;Fertilization;fitness;Future;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;Generations;Genes;Genetic;genetic manipulation;Genetic Transcription;Genome;genome-wide;Germ;Germ Cells;Germ Lines;Global Change;Goals;Histone H3;histone modification;Infertility;Inherited;Knock-out;life span;Lysine;male;male fertility;Male Infertility;Malignant Neoplasms;Maps;Methylation;Modeling;Molecular;Morphology;Mus;mutant;Mutant Strains Mice;Mutation;National Institute of Child Health and Human Development;neuronal cell body;next generation;non-genetic;novel;Nutritional;offspring;Oncogenes;Paternal Exposure;Pathway interactions;Perinatal;Phenotype;Placenta;Predisposition;preimplantation;programs;Regulation;Regulator Genes;Reproducibility;Reproduction;Reproductive Biology;Role;sperm cell;Spermatocytes;Spermatogenesis;Spermatogenic Cell;Structure of primordial sex cell;System;Testing;Time;Tissues;transcriptome;transgenerational epigenetic inheritance;transmission process;tumor;Tumor Burden;Tumor Suppressor Proteins;tumorigenesis;Work;X Chromosome;zygote

PROJECT_TITLE: Germline Utx mutation as a model for transgenerational epigenetic inheritance

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: ATLANTA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Alzheimer's Disease (AD) is rapidly becoming an overwhelming economic and social burden. This proposal will study cerebrovascular function, diffusion measures of white matter injury in the early phases of AD, and use these measures to predict cognitive decline in subjects with AD pathology. Successful execution of the study will provide a better understanding of the interaction between cerebrovascular and AD pathology in the early phases of AD that could eventually lead to the development of effective multi-component therapeutic interventions of AD that target both AD and vascular pathologies.

PI_NAMEs: QIU, DEQIANG  (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: abeta deposition;Acceleration;Address;Adult;Alzheimer's Disease;Alzheimer's disease care;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;American;Amyloid beta-Protein;Animal Model;Area;asymptomatic Alzheimer's disease;Automobile Driving;Axon;Biological;Biological Markers;Blood Vessels;Brain;Brain Injuries;cerebral hemodynamics;cerebrovascular;Cerebrovascular Disorders;cerebrovascular pathology;cerebrovascular reactivity;Chronic;Clinical;Clinical Trials;Cognitive;cognitive performance;Communities;Dementia;Demyelinations;Deterioration;Development;Diabetes Mellitus;Diameter;Diffusion;Diffusion Magnetic Resonance Imaging;Economics;Elderly;Ensure;epidemiology study;Functional disorder;Goals;Health;healthy aging;hemodynamics;Hemorrhage;high risk;Hospice Care;Human;hypercholesterolemia;Hypertension;hypoperfusion;Imaging Techniques;Impaired cognition;Impairment;improved;insight;Knowledge;Learning;Leukoaraiosis;life span;Magnetic Resonance;Magnetic Resonance Imaging;Measures;middle age;mild cognitive impairment;Molecular;Neurofibrillary Tangles;Neurons;Outcome;Pathology;payment;Phase;prodromal Alzheimer's disease;Research;Research Infrastructure;Risk Factors;Role;Signal Transduction;social;Structure;Symptoms;Techniques;Therapeutic Intervention;Tissues;vascular contributions;white matter;White Matter Hyperintensity;white matter injury

PROJECT_TITLE: Cerebral hemodynamic impairment in symptomatic and asymptomatic Alzheimer's Disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: LM

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Women's Health Research

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project Narrative Unsupervised clustering methods have been widely used to identify patient subgroups using omics experimental data to achieve more tailored treatment decision and precision medicine in complex diseases. In this project, we propose to develop an outcome-guided disease subtyping framework to perform disease subtyping with guidance from critical clinical outcomes so that the identified disease subtypes are clinically more relevant and actionable, which can ultimately translate into bedside practice and benefit patients.

PI_NAMEs: TSENG, GEORGE C. (contact)

PROGRAM_OFFICER_NAME: MISQUITTA, LEONIE

PROJECT_TERMS: Biological;Biological Markers;Childhood Asthma;Clinical;clinical phenotype;clinical practice;clinical subtypes;clinically actionable;Cluster Analysis;cohort;Collaborations;Complex;Copy Number Polymorphism;Data;Data Analyses;data integration;Data Set;Databases;design verification;Disease;disease heterogeneity;disease prognosis;Disease Progression;disorder subtype;Exclusion;experimental study;feature selection;Foundations;Future;Generations;Genes;Graph;high dimensionality;improved;individualized medicine;interest;Knowledge;Letters;Literature;Lobular Carcinoma;Lung Diseases;machine learning method;Malignant Breast Neoplasm;Messenger RNA;Methods;Methylation;methylome;MicroRNAs;Modeling;Molecular;Molecular Disease;Molecular Profiling;Multiomic Data;new therapeutic target;novel;Outcome;Pathway interactions;patient subsets;Patients;precision medicine;Process;Prognosis;Proteome;Randomized;Sampling;Structure;survival outcome;Technology;transcriptome;Translating;treatment effect;treatment response;unsupervised clustering;unsupervised learning;Validation

PROJECT_TITLE: Disease subtyping guided by clinical phenotype for precision medicine

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: BIOCHEMISTRY

PHR: Project Narrative Genetic variants in NMDA receptor subunits, including variants within the intracellular tail of the GluN2B subunit greatly increase risk for schizophrenia, autism, and related neurodevelopmental disorders, but how they impact NMDAR function is unclear. My proposed studies will elucidate a novel mechanism by which GluN2B intracellular tails regulate NMDAR function. These studies could reveal whether distinct functions of NMDAR subunits could serve as a potential target for therapeutic interventions to treat NMDAR-associated disorders.

PI_NAMEs: CARRIZALES, MELISSA  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Actin-Binding Protein;Actins;Affect;Affinity;Amino Acids;autism spectrum disorder;Binding;Biochemical;Biological Assay;Brain Diseases;Cells;Charge;Complex;crosslink;Cytoplasmic Tail;Cytoskeletal Proteins;Cytoskeleton;Data;Dendritic Spines;density;Development;Disease;Drug Targeting;Epilepsy;Excitatory Synapse;experimental study;Genes;genetic variant;Glutamate Receptor;Goals;Hippocampus;Intellectual functioning disability;Ion Channel Gating;Learning;Maps;Mass Spectrum Analysis;Measures;Mediating;Membrane;Memory;Microfilaments;Monitor;mutant;N-Methyl-D-Aspartate Receptors;Neurodevelopmental Disorder;Neurons;NMDA receptor A1;novel;Patients;Peptides;polymerization;Polymers;postsynaptic;Proteins;receptor function;Recombinant Proteins;Recombinants;Regulation;response;Role;Schizophrenia;schizophrenia risk;Sedimentation process;Shapes;small molecule;stoichiometry;Synapses;synaptic function;Synaptic Receptors;Tail;targeted treatment;Techniques;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;trafficking;Variant;Vertebral column;Whole-Cell Recordings

PROJECT_TITLE: Regulation of GluN2B-NMDA Receptors by Interactions with the Actin Cytoskeleton

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

ORG_CITY: STONY BROOK

ORG_DEPT: PSYCHIATRY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: Project Narrative  Schizophrenia poses a great social and economic burden in a significant percentage of patients, including increased risk for unemployment, homelessness, incarceration, chronic disability, and reduced life expectancy. This disability is thought to be closely related to cognitive deficits in patients. By seeking to better understand the neural basis of these deficits, this application seeks to identify new brain mechanisms that may be targeted by future treatments in order to improve outcomes in this patient group.

PI_NAMEs: VAN SNELLENBERG, JARED XAVIER (contact)

PROGRAM_OFFICER_NAME: FERRANTE, MICHELE

PROJECT_TERMS: Area;Attention;attentional control;behavior test;Behavioral;Biological Assay;biomarker identification;biotypes;Brain;Brain region;case control;Chronic disability;Clinical Trials;Cognition;Cognitive;cognitive ability;Cognitive deficits;cognitive neuroscience;cognitive process;cognitive task;Collection;convolutional neural network;Data;Data Set;disability;Economic Burden;effective therapy;Equation;Exhibits;flexibility;Functional disorder;Functional Magnetic Resonance Imaging;functional MRI scan;functional outcomes;Future;Goals;Homelessness;imaging study;Impairment;Imprisonment;improved;improved outcome;Individual;interest;Life Expectancy;Link;Literature;long term memory;Maintenance;Maps;Memory;Memory impairment;memory retrieval;Modeling;Motivation;National Institute of Mental Health;neural;neural circuit;neural correlate;neural network;Neural Network Simulation;Outcome;Participant;Pathogenesis;patient subsets;Patients;Pattern;Performance;potential biomarker;Process;Psychiatric Diagnosis;Psychiatry;psychotic symptoms;Recommendation;repetitive transcranial magnetic stimulation;Reporting;Research;Research Domain Criteria;Research Personnel;Risk;Role;Sampling;Schizophrenia;Short-Term Memory;social;Specific qualifier value;Structure;Symptoms;Task Performances;Techniques;Testing;treatment research;Unemployment;Update;Work

PROJECT_TITLE: A data-driven reconceptualization of the RDoC construct of working memory: Neural correlates of underlying factors and implications for schizophrenia

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ED_INST_TYPE: SCH OF BUSINESS/PUBLIC ADMIN

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Atherosclerosis;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Hematology;Precision Medicine

ORG_CITY: LAS CRUCES

ORG_DEPT: MISCELLANEOUS

ORG_NAME: NEW MEXICO STATE UNIVERSITY LAS CRUCES

ORG_STATE: NM

PHR: Project Narrative: Acute myocardial infarction (heart attack) is one of the leading causes of death in the United States and globally. Currently a non-invasive method of determining the underlying cause of an acute myocardial infarction does not exist, and it is unknown how different causes of acute myocardial infarction affect or alter metabolic processes. This project will use previously collected blood plasma from humans experiencing an acute myocardial infarction to develop a diagnostic method for determining the underlying cause of the event and how the different causes alter metabolic processes.

PI_NAMEs: TRAINOR, PATRICK J (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Acute myocardial infarction;Address;Affect;Angiography;Arterial Fatty Streak;atherosclerotic plaque rupture;Biochemical Reaction;Biological;Biological Markers;Biological Process;Blinded;Blood coagulation;Blood flow;Cardiac Myocytes;Categories;Cause of Death;Cell Death;Cell-Cell Adhesion;Cessation of life;Characteristics;Classification;Clinical;Coagulation Process;cohort;Coronary;Coronary Arteriosclerosis;Data;data integration;design;Detection;Development;Diagnostic;diagnostic criteria;Diagnostic Procedure;Diagnostic tests;differential expression;Ensure;Etiology;Evaluation;Event;experience;feature selection;Fibrinolysis;follow-up;genome-wide;Guidelines;Hour;Human;human subject;improved;Infarction;insight;International;Investigation;Knowledge;Ligand Binding;Ligands;lipid metabolism;lipidomics;Lipids;liquid chromatography mass spectrometry;Mass Spectrum Analysis;Measures;Metabolic;Metabolic Pathway;Metabolism;metabolome;metabolomics;Methods;Modeling;Monitor;mortality;multiple omics;Myocardial;Myocardial Infarction;Myocardial Ischemia;Myocardium;Necrosis;new therapeutic target;noninvasive diagnosis;novel diagnostics;Oxygen;Pathologic;patient safety;Patient-Focused Outcomes;Patients;Performance;Plasma;Plasma Proteins;Platelet Activation;Procedures;Process;Proteins;Proteome;proteomic signature;Proteomics;Reaction;receptor;Reporting;Research Design;Resolution;Rupture;Sampling;Secondary to;statistical and machine learning;Statistical Models;System;Systems Biology;targeted treatment;Therapeutic Intervention;Thrombosis;thrombotic;Thrombus;Time;treatment strategy;United States;Vascular blood supply;Work

PROJECT_TITLE: Integrated proteomic and metabolomics analysis of thrombotic myocardial infarction


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Alzheimer’s disease affects one in ten people over the age of 65 and our current understanding of the cause is limited. Recent data from experimental models and human neuroimaging indicates that impaired vascular function is a key component of disease and understanding the cause of these changes could greatly enhance our approach to slowing or even preventing cognitive decline. These studies will identify specific changes in gene expression within the brain’s smallest blood vessels, will examine how these changes contribute to altered vascular integrity in disease, and will determine if these findings could be used to develop new vascular-directed therapies for use in Alzheimer’s disease.

PI_NAMEs: BENNETT, RACHEL ELISE (contact)

PROJECT_TERMS: 3-Dimensional;abeta accumulation;Affect;Age;Age-associated memory impairment;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;angiogenesis;Animals;Automobile Driving;Biological;Biological Markers;Blood;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood capillaries;Blood flow;Blood Vessels;blood-brain barrier function;blood-brain barrier permeabilization;Brain;Brain region;cardiovascular disorder risk;Cell Aging;Cells;cerebral microvasculature;Cerebrovascular Circulation;Cerebrovascular system;Cognition;Data;Dependovirus;Deposition;Disease;Disease susceptibility;Endothelial Cells;Epitopes;Experimental Models;Extravasation;Functional disorder;Functional impairment;Future;Gene Delivery;Gene Expression;Genes;genetic manipulation;Heterogeneity;Histologic;Histology;Human;human data;human imaging;human old age (65+);human tissue;Hypertension;imaging study;Immunofluorescence Immunologic;Impaired cognition;Impairment;Individual;Inflammation;innovation;insight;Knowledge;Lasers;Lesion;Link;Massachusetts;Measures;Mediating;Mediator;Medical;Methods;Microvascular Dysfunction;mild cognitive impairment;Molecular;molecular marker;Morphology;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroimaging;neuron loss;Neurons;novel;overexpression;Pathologic;Pathology;Pathway interactions;patient population;Persons;Plasminogen Activator Inhibitor 1;Plasminogen Inactivators;Preparation;prevent;Process;Proteins;reconstruction;regional difference;Reporting;Research;resilience;Risk Factors;RNA;Role;Sampling;senescence;Senile Plaques;SERPINE1 gene;Serum Proteins;Severities;spatial relationship;Specificity;Stress;stressor;targeted treatment;tau Proteins;Techniques;Testing;Therapeutic;therapeutic gene;Tissue Sample;Tissues;tool;transcriptome;transcriptomics;Transgenic Mice;Up-Regulation;Vascular Endothelium;vascular inflammation;vascular risk factor;vascular stress;Work

PROJECT_TITLE: Microvascular Stress as a Pathway to Neurodegeneration in Alzheimer's


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: LA JOLLA

ORG_DEPT: ZOOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Bacterial therapeutics have recently been developed for the in vivo delivery of protein and peptide agents. The goal of this proposal is to explore if such technology can be extended to small molecule drugs. I plan to engineer a probiotic E. coli strain to overproduce and secrete the neuropharmaceutical prodrug candidate L-4- chlorokynurenine and measure systemic distribution of the compound inside a mouse model.

PI_NAMEs: BUSHIN, LEAH  (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: 7-chlorokynurenic acid;absorption;Anabolism;Animal Model;Animals;Attention;Bacteria;Behavior;Biological Assay;Biological Markers;Biomass;Biomedical Engineering;Biomedical Research;Biomedical Technology;Blood;Blood Circulation;Brain;cancer cell;carbene;Carbon;Catabolism;Chemicals;Circulation;Cloning;cofactor;combinatorial;Coupled;Coupling;design;detection limit;Development;Devices;Directed Molecular Evolution;Disease;disorder prevention;Drug Delivery Systems;Dryness;Engineered Probiotics;Engineering;Enzymes;Escherichia coli;Evolution;experimental study;Formates;Gene Deletion;Genes;Genetic;Genetic Variation;genome-wide;Goals;Growth;halogenation;Health;Health Promotion;High Pressure Liquid Chromatography;Hormones;Human;improved;In Situ;In Vitro;in vivo;Inborn Errors of Metabolism;individualized medicine;interest;Invaded;Laboratories;Lead;Libraries;marine;Measures;Medicine;Metabolic;metabolic engineering;Metabolism;Microbe;microbiome;microbiome research;microbiome therapeutics;microorganism;Modeling;Modernization;Modification;mouse model;multidisciplinary;Multiomic Data;Mus;mutant;Mutate;Mutation;Natural Products;non-Native;Pathway interactions;Peptides;Pharmaceutical Preparations;Play;Probiotics;Prodrugs;Production;programs;Property;Proteins;Pseudomonas putida;Reporting;Ribosomes;Role;Safety;sample fixation;Sampling;small molecule;small molecule therapeutics;Source;stool sample;synthetic biology;System;Technology;Testing;Therapeutic;Therapeutic Agents;Therapeutic Intervention;tool;Training;training opportunity;Tryptophan;Urine;Variant;Work

PROJECT_TITLE: Engineering bacteria for production and delivery of the halogenated prodrug lead L-4-chlorokynurenine


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Orphan Drug;Patient Safety;Pediatric;Pediatric Cancer;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

PHR: Project Narrative Despite improvements in childhood cancer survival over the last several decades, marked racial, ethnic, and socioeconomic disparities in outcomes persist. Thus, understanding the socioeconomic factors contributing to disparities in relapse, toxicities, and survival may allow for intervention measures in the future.

PI_NAMEs: MARCOTTE, ERIN  (contact)

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: Acute Lymphocytic Leukemia;Address;Adolescent;Adverse event;adverse outcome;Area;Biological;Canada;cancer diagnosis;Cancer Patient;Cancer Relapse;cancer survival;cancer type;Caring;Censuses;Central Nervous System Neoplasms;Cephalic;Cessation of life;Child;Clinical Trials Cooperative Group;cohort;Collection;Common Terminology Criteria for Adverse Events;comorbidity;Cytogenetics;Data;Diagnosis;Disparity;economic determinant;Enrollment;ethnic disparity;Ethnic Origin;experience;Factor Analysis;Fever;follow-up;Future;Goals;hazard;Hispanic;Hospitals;improved;indexing;Infection;Institution;Insurance Coverage;International;Intervention;leukemia;Location;Logistic Regressions;low socioeconomic status;Lymphoma;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;Mediating;Mediation;Methods;Minnesota;Molecular;Morbidity - disease rate;mortality;Necrosis;Neoadjuvant Therapy;Neuropathy;Neutropenia;Not Hispanic or Latino;Odds Ratio;Outcome;outcome prediction;Outcome Study;Parents;participant enrollment;Pathway interactions;patient population;Patients;Pediatric Oncology Group;Population;Primary Neoplasm;Protocols documentation;Race;racial disparity;Recommendation;Registries;Relapse;relapse risk;Research;Research Personnel;Residual Neoplasm;Resources;Risk;Risk Reduction;risk stratification;Serious Adverse Event;sex;socioeconomic disparity;Socioeconomic Factors;Socioeconomic Status;socioeconomics;Solid Neoplasm;Standardization;Survival Rate;Survivors;survivorship;Therapeutic Trials;therapy outcome;Time;tool;Toxic effect;translational potential;Treatment-related toxicity;tumor;United States;Work

PROJECT_TITLE: Socioeconomic determinants of childhood cancer outcomes in a large contemporary cohort

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Disability Research;Neurodegenerative;Neurosciences;Patient Safety;Prevention;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Intracerebral hemorrhage is complex, has long-term significant cognitive and functional impairment, and has no proven treatment, resulting in a disproportionate disability rate and lifetime cost among stroke survivors. By employing novel cognitive outcomes methodology to study long-term outcomes in ICH with enhanced retention, we may accelerate understanding of the causes of cognitive impairment after ICH. In the REpeated ASSEssment of SurvivorS in IntraCerebral Hemorrhage study (REASSESS ICH), we will determine whether reduction of ICH volume with minimally invasive surgery is a critical target to reducing the risk of progressive cognitive decline, targets for residual hematoma volume and whether inflammatory pathways in particular predict patients with cognitive impairment independent of gene risk scores for dementia and surgical status.

PI_NAMEs: FLAHERTY, MATTHEW ;ZIAI, WENDY C (contact)

PROGRAM_OFFICER_NAME: JANIS, SCOTT

PROJECT_TERMS: Acceleration;Acute;Address;Age;aging brain;Alteplase;arm;Automobile Driving;Biological Process;Cerebral Amyloid Angiopathy;Cerebral hemisphere hemorrhage;Chronic;Clinical;Clinical Trials;Coagulation Process;Cognitive;comparative;Complex;cost effective;Data;Death Rate;Dementia;design;disability;Encephalitis;Enrollment;Ethnic Origin;Excision;follow-up;Follow-Up Studies;Functional dependence;Functional impairment;functional outcomes;Funding;Gene Expression;Genes;Genotype;Hematoma;Hemorrhage;high risk;Hispanic;hypertension treatment;Impaired cognition;improved;Incidence;Inflammation;Inflammatory;Injury;interest;Ischemic Stroke;Leukoaraiosis;life time cost;Lobar;Location;Longitudinal Studies;Longterm Follow-up;Methodology;minimally invasive;mortality;mortality risk;neuropsychiatry;novel;Observational Study;Operative Surgical Procedures;Outcome;Outcome Assessment;Outcome Study;Participant;participant enrollment;Pathway interactions;Patients;Performance;Persons;prospective;Race;Randomized, Controlled Trials;recruit;Reporting;Residual state;Residual volume;Resources;response;Risk;Risk Factors;risk prediction;Risk Reduction;risk variant;sex;Site;standard care;standard of care;Stroke;stroke survivor;Structure;Suggestion;Supratentorial;survival outcome;Survivors;Target Populations;Techniques;Telephone Interviews;Testing;Time;treatment strategy;United States National Institutes of Health;Variant;Visit;White Matter Disease

PROJECT_TITLE: REpeated ASseSsmEnt of SurvivorS in ICH (REASSESS ICH)

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Sleep Research;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative Opioid Withdrawal Syndrome (OWS) consists of many negatively affective and physical symptoms that often incentivize individuals to relapse. Understanding the mechanisms underlying this stage of Opioid Use Disorder may inform future therapeutics and treatment options for OWS, preventing relapse and continued opioid misuse. Specifically, this proposal lays out experiments designed to investigate the effects of opioid withdrawal on the GABAergic signaling between two implicated brain regions, the bed nucleus of the stria terminalis (BNST) and the ventral tegmental area (VTA).

PI_NAMEs: BEDARD, MADIGAN  (contact)

PROGRAM_OFFICER_NAME: BABECKI, BETH

PROJECT_TERMS: Acute;Affect;Affective Symptoms;Animals;Anxiety;Behavior;Behavior Control;Behavioral;behavioral study;Brain region;Cells;Clinical;comparison control;Coupled;Data;Dependovirus;designer receptors exclusively activated by designer drugs;Diarrhea;Economic Burden;Economics;Electrophysiology (science);Enterobacteria phage P1 Cre recombinase;Epidemic;Experimental Designs;experimental study;Exposure to;Female;Fright;Future;gamma-Aminobutyric Acid;Glutamates;Hour;improved;in vivo;Incentives;Individual;interest;Interneurons;knock-down;Label;Literature;male;Measurable;Measures;Mediating;Mental Depression;Modification;Morphine;Mus;negative affect;Negative Reinforcements;neural circuit;neurobiological mechanism;Neurobiology;Neurons;Neurosciences;Opioid;opioid epidemic;opioid exposure;opioid misuse;opioid overdose;opioid use;opioid use disorder;opioid withdrawal;optogenetics;Output;Pathway interactions;Persons;Pharmaceutical Preparations;physical symptom;Physiologic pulse;Population;Positive Reinforcements;prevent;Publishing;Relapse;relapse prevention;Reporter;Research;Rewards;Role;Signal Transduction;skills;sleep behavior;Sleep disturbances;sleep pattern;sleep regulation;Sleeplessness;small hairpin RNA;social;Structure of terminal stria nuclei of preoptic region;Substance Withdrawal Syndrome;Sweating;Symptoms;Synapses;Synaptic Transmission;Technology;Testing;Therapeutic;Tooth structure;Training;transmission process;Tremor;United States;Ventral Tegmental Area;Viral;voltage clamp;Vomiting;Weight;Whole-Cell Recordings;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: GABAergic alterations in the BNST to VTA circuit following morphine withdrawal


NIH_SPENDING_CATS: Bioengineering;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: BROAD INSTITUTE, INC.

PHR: Narrative Microscopy images of cells, when analyzed by computers, can reveal powerful information about a cell. They can reveal a breadth of information about a cell’s response to changes: whether a disease, a change in their genes, or treatment by a drug. The project will develop new algorithms and test various applications using image data, aiming to accelerate biological discoveries and drug development.

PI_NAMEs: CARPENTER, ANNE E. (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Acceleration;Affect;Algorithms;Biological;Biological Assay;biological research;Cells;cellular imaging;Chemicals;Computer software;Computers;Data;Data Sources;deep learning algorithm;deep learning model;deep neural network;Disease;drug development;drug discovery;feature extraction;gene function;Genes;Genetic;Image;interest;invention;Learning;Location;Measures;Methods;microscopic imaging;Morphology;multimodality;novel;Organism;Paint;Pathway interactions;Pharmaceutical Preparations;Phenotype;predictive modeling;predictive test;public-private partnership;Research;response;scale up;small molecule;Stains;Structure;Techniques;Technology;Testing;Toxic effect;Training;virtual screening;Visualization

PROJECT_TITLE: Advancing image-based profiling

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ORG_DEPT: CHEMISTRY

PHR: Project Narrative Prostate cancer is the third leading cause of cancer-related death in men in the United States. Fatty acid binding protein 5 is expressed in advanced prostate cancer and its inhibition suppresses tumor growth and metastasis. This proposal seeks to develop inhibitors targeting fatty acid binding protein 5 for the treatment of prostate cancer.

PI_NAMEs: KACZOCHA, MARTIN ;OJIMA, IWAO  (contact);RIZZO, ROBERT C.;TROTMAN, LLOYD C

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Acids;advanced prostate cancer;Affinity;Algorithm Design;Ames Assay;analog;Androgen Antagonists;androgen independent prostate cancer;androgen sensitive;Binding;Biological;Biological Assay;Cancer Biology;Cancer Etiology;Castration;Cell Line;Cells;Cessation of life;chemical synthesis;Clinical;Computer Assisted;Cytochrome P450;Cytoplasm;cytotoxicity;Data;design;Development;Disease;Docking;Drug Design;Drug Kinetics;Early Diagnosis;efficacy evaluation;efficacy testing;Enzymes;fatty acid metabolism;fatty acid-binding proteins;FDA approved;Free Energy;Generations;Genetic Transcription;Genetically Engineered Mouse;Goals;Half-Life;Heart;improved;in silico;In Vitro;in vivo;in vivo evaluation;inhibitor;Injections;Intervention;intracellular protein transport;Ion Channel;Lead;lead optimization;Link;lipid transport;Lipids;Malignant neoplasm of prostate;Maps;men;Metabolism;Metastatic Prostate Cancer;Microsomes;Molecular;molecular dynamics;mouse model;multidisciplinary;Mus;MYC gene;Neoplasm Metastasis;next generation;novel;novel therapeutics;Nuclear Receptors;Nude Mice;Outcome;Patients;Pharmaceutical Chemistry;Plasma;Positioning Attribute;pre-clinical;Preclinical Testing;Production;programs;Prostate;prostate cancer cell line;prostate cancer metastasis;prostate cancer model;Prostate Cancer therapy;Prostatic;Protein Isoforms;Proteins;Qualifying;rational design;receptor;Receptor Signaling;Resistance;scaffold;screening;Signal Transduction;Structure;subcutaneous;System;targeted treatment;taxane;Techniques;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;Translations;tumor growth;Tumor Promotion;tumorigenic;United States

PROJECT_TITLE: Development of the Next Generation of FABP5 Inhibitors to Treat Prostate Cancer

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE One of the most interesting questions in science is how individual cells robustly communicate with each other in complex and rapidly changing environments using signaling pathways, whose mechanistic details are not understood. Quantitative characterization of signaling pathways in living cells would lead to accurate computational models of emergent signaling outcomes in health and disease, as well as better therapies in a range of conditions including infection, autoimmunity, and cancer. We will use live-cell experiments, modeling and bioengineering approaches to study information processing by individual cells and cell populations, and develop enabling new technologies with improved accuracy and throughput for better study of biological information processing by single cells.

PI_NAMEs: TAY, SAVAS  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Attention;Autoimmunity;automated image analysis;Biological Assay;biological information processing;Biological Models;Biomedical Engineering;Cell Physiology;Cell Signaling Process;Cells;Characteristics;Coculture Techniques;combinatorial;Communication;Complex;Computer Models;cytokine;density;Development;Disease;Environment;Epithelial Cells;Event;experimental study;Exposure to;Gene Expression;Goals;Grant;Health;high throughput technology;Immune signaling;Immunity;improved;Individual;Infection;Inflammatory;information processing;Laboratories;Malignant Neoplasms;Measurement;memory encoding;Messenger RNA;Methods;microfluidic technology;Microfluidics;Modeling;Myeloid Cells;new technology;Organoids;Outcome;pathogen;Pathway interactions;Population;Process;Production;protein complex;Protein Secretion;Proteins;response;Science;segmentation Image analysis;Sentinel;Sepsis;Signal Pathway;signal processing;Signal Transduction;Signaling Molecule;single cell analysis;single cell proteins;single cell sequencing;Statistical Methods;Stimulus;Stress;System;Technology;technology development;Time;Transcription Process

PROJECT_TITLE: Understanding robust cellular information processing in complex environments and development of enabling single-cell analysis technologies

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative This study is to understand neuronal underpinnings of the sex-specific diverse consequences of adolescent stress. Combined approaches will be used to test the hypothesis that circuit-specific alterations of neuronal functions in stressed males and females, which are driven by circuit-specific changes in gene expression, mediate the sexually dimorphic effects of early life stress. It will offer insights into the development of novel precision therapy to mitigate the distinct deficits in males and females after stress exposure.

PI_NAMEs: YAN, ZHEN  (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Address;Adolescent;Aggressive behavior;Amygdaloid structure;Animal Model;Animals;antisocial behavior;Anxiety Disorders;Behavioral;Behavioral Assay;behavioral impairment;behavioral phenotyping;Behavioral Symptoms;Brain;Calcium Signaling;Child;Chronic;Chronic stress;Complex;Depressive disorder;Development;early life adversity;early life stress;Electrophysiology (science);Emotional;emotional neglect;Exposure to;Female;Functional disorder;Gene Expression;Gene Mutation;Gene Transfer;Genetic;genetic technology;Goals;Homeostasis;Hormonal;Hormones;Human;Hyperactivity;Impulsivity;in vivo;insight;life span;male;Mediating;men;Mental Depression;Mental disorders;Messenger RNA;Modeling;Molecular;Mood Disorders;Mus;neglect;neural;neuronal circuitry;neuronal excitability;Neurons;novel;optogenetics;patch clamp;Pathway interactions;Performance;Phenotype;Physiological;Play;Precision therapeutics;Prefrontal Cortex;Prevalence;Puberty;Role;sex;sexual dimorphism;Slice;social;social contact;social exclusion;Social isolation;Stress;stressor;Symptoms;Synapses;Synaptic Transmission;Techniques;Testing;transcriptome sequencing;Ventral Tegmental Area;Violence;Viral;Weaning;Withdrawal;Woman

PROJECT_TITLE: Synaptic and Genetic Mechanisms of Sex-Specific Effects of Stress

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: Narrative Cancer development is associated with immune suppression, and therefore lifting the suppression has achieved a certain degree of success to effectively treat a proportion of cancer patients. A family of protein called PIM kinases (1, 2 and 3) plays a prominent role in promoting tumor growth, but our recent study indicates that one family member (PIM-2) strongly restrains T lymphocyte responses against tumor. In the current research, we will test how inhibition of PIM-2 kinase promotes immunity against cancer while directly suppressing tumor growth, which may reveal a novel strategy for effective cancer immunotherapy.

PI_NAMEs: YU, XUE-ZHONG  (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Acute T Cell Leukemia;Adaptive Immune System;Alloantigen;Allogeneic Bone Marrow Transplantation;Antigens;Antitumor Response;autoimmune pathogenesis;Breast Cancer Model;cancer cell;cancer immunotherapy;Cancer Patient;cancer type;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Cycle Progression;Cell Survival;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;CTLA4 gene;Data;Development;Dioxygenases;Enzymes;Epitopes;Event;Family member;FOXP3 gene;Genetic;graft versus host disease induction;Hematology;Human;Immune;immune checkpoint;immune checkpoint blockade;Immune Evasion;Immune Tolerance;Immunity;Immunosuppression;Immunotherapy;Implant;improved;Individual;inhibitor;integration site;Investigation;Knock-in;Knock-out;Knockout Mice;Knowledge;Lifting;Malignant Neoplasms;Mediating;Melanoma;Metabolic;Modeling;Molecular;Moloney Leukemia Virus;Mus;Mutant Strains Mice;Myeloid-derived suppressor cells;novel strategies;overexpression;Pathway interactions;PD-1 blockade;pharmacologic;Phosphorylation;Phosphotransferases;Play;prevent;programmed cell death protein 1;Protein Family;Protein Isoforms;proto-oncogene protein pim;Provirus Integration;Publishing;Regulation;Regulatory T-Lymphocyte;Research;response;restraint;Role;Signal Transduction;SILV gene;small hairpin RNA;Source;success;T cell response;T-Cell Activation;T-Cell Receptor Genes;T-Lymphocyte;Testing;therapeutic target;Time;Tissues;Transgenic Organisms;translational approach;Transplantation;tumor;Tumor Antigens;tumor growth;Tumor Immunity;tumor progression;Tumor Promotion;tumorigenesis;Work

PROJECT_TITLE: Targeting PIM-2 Kinase for Improving Cancer Immunotherapy

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Biotechnology;Cancer;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative  The proposed research is relevant to public health since the resistance of tumors to available therapies remains the major cause of cancer mortality. A better understanding of howresistance develops, and the specific vulnerabilities each resistance mechanism poses, will provide new treatment opportunities. The inclusion of selective Bcl2 family inhibitors into clinical care, driven by this fundamental knowledge, will have broad reach in improving cancer outcomes.

PI_NAMEs: HOGARTY, MICHAEL D (contact)

PROGRAM_OFFICER_NAME: DEY, SUMANA MUKHERJEE

PROJECT_TERMS: Adopted;Adult;Apoptosis;Apoptotic;BCL-2 Protein;BH3 Domain;BIM Bcl-2-binding protein;Binding;Biological Assay;Biological Markers;cancer care;cancer cell;Cancer Etiology;Cancer Patient;cell growth;Cell Line;Cellular Stress;Cessation of life;Chronic;Clinic;Clinical;clinical care;clinical efficacy;clinical translation;Clinical Trials Design;Co-Immunoprecipitations;Combined Modality Therapy;Credentialing;cytochrome c;Data;Death Domain;Dependence;Development;Diagnosis;diagnostic assay;Diagnostic tests;diagnostic tool;drug efficacy;Environment;Exposure to;Family;Family member;Formalin;genomic predictors;Genomics;Goals;Growth;Hematologic Neoplasms;Heterogeneity;improved;In Situ;In Vitro;in vivo;in-vitro diagnostics;Infrastructure;inhibitor;inhibitor therapy;innovation;insight;Invaded;Knowledge;Ligation;Lymphocyte;Malignant Neoplasms;MAP Kinase Gene;MCL1 gene;Measures;Mediating;MEKs;Mitochondria;Mitogen-Activated Protein Kinase Inhibitor;Modeling;mortality;Mutation;Myeloid Leukemia;neoplastic cell;Neuroblastoma;novel diagnostics;Outcome;Paraffin Embedding;Pathway interactions;patient derived xenograft model;patient subsets;Patients;Pediatric Neoplasm;Pharmaceutical Preparations;Play;precision medicine;predictive marker;predictive test;Primary Neoplasm;Process;Protein Family;protein protein interaction;Proteins;Public Health;Relapse;Research;Resistance;resistance mechanism;response;Role;Signal Transduction;Site;Slide;Solid Neoplasm;Stress;survival prediction;synergism;Tertiary Protein Structure;Testing;Therapeutic;tumor;Validation;Work

PROJECT_TITLE: Mechanistic biomarkers to enable Bcl2 inhibitor therapies for neuroblastoma

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


NIH_SPENDING_CATS: Cancer;Genetics;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative DSRCT is an aggressive childhood cancer which does not respond well to standard therapy. The studies proposed in this application will identify new vulnerable targets and oncogenic pathways in DSRCT. The identification of highly tumorigenic spheroids in DSRCT will reveal additional vulnerable targets. The findings of this study will identify new vulnerabilities in DSRCT that will ultimately lead to development of effective targeted therapies in DSRCT.

PI_NAMEs: LEE, SEAN B. (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: B-Lymphocytes;Biological Models;cancer type;cell growth;Cell Survival;cell type;Cells;chemotherapy;childhood sarcoma;Chromosomal translocation;comparison control;Data;Data Set;Dependence;Desmoplastic Small Round Cell Tumor;Development;Event;Ewings sarcoma;EWS-FLI1 fusion protein;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Gene Family;Gene Fusion;Genes;Goals;In Vitro;in vivo;inhibitor;intraperitoneal;Malignant Childhood Neoplasm;Malignant Neoplasms;mortality;Mus;neoplastic cell;new therapeutic target;novel;NTRK3 gene;Oncogenic;Ontology;Pathway interactions;Patients;Pharmaceutical Preparations;Phosphotransferases;Population;Prognosis;Proliferating;Radiation therapy;Radiosurgery;Recurrence;Recurrent tumor;Relapse;Resistance;response;Role;Sampling;Sarcoma;small hairpin RNA;spheroids;standard care;stem cell genes;targeted treatment;Therapeutic;transcription factor;transcriptome sequencing;tumor;tumor growth;tumor initiation;tumorigenesis;tumorigenic;WT1 gene;Xenograft Model

PROJECT_TITLE: An Integrative Approach to Identify Vulnerabilities in Pediatric Cancer DSRCT


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Precision Medicine;Prostate Cancer;Urologic Diseases

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: PROJECT NARRATIVE Epigenetic alterations have been identified as playing a critical role in the development and progression of cancer. Current epigenetic assays require large numbers of cells (thousands to millions) with limited capability to analyze rare cells or tumor heterogeneity. This proposal seeks to develop new microfluidic technologies to evaluate epigenetic alterations in rare cells that can be used to improve our understanding of cancer, develop new therapeutic interventions and support biomarker development.

PI_NAMEs: BEEBE, DAVID J (contact);LANG, JOSHUA MICHAEL

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Acceleration;Address;Adsorption;Aggressive behavior;Air;Antibodies;aqueous;Area;Automation;Benchmarking;Binding;Binding Proteins;Biological;Biological Assay;Biological Models;biomarker development;biomarker validation;Biopsy;bisulfite sequencing;cancer therapy;Cell Count;cell immortalization;Cell Line;Cells;chemotherapy;Chromatin;chromatin immunoprecipitation;Chromatin Structure;Clinic;Clinical;Clinical Trials;Complex;Core Biopsy;Coupling;Data;Development;Devices;diagnostic biomarker;Disease Progression;Dissociation;DNA;DNA Binding;DNA Methylation;DNA Sequence;DNA Sequence Alteration;DNA-Binding Proteins;Ensure;epigenetic marker;Epigenetic Process;epigenome;epigenomics;Exclusion;Fine needle aspiration biopsy;Force of Gravity;Frequencies;Future;Gene Expression;Gene Silencing;Genes;Genetic Transcription;genomic aberrations;genomic biomarker;Genomics;Goals;GSTP1 gene;Histone Acetylation;histone modification;Histones;hormonal signals;hormone therapy;Human;Hypermethylation;Immune Evasion;improved;interest;Kinetics;Liquid substance;magnetic field;Magnetism;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;Measures;Methods;Methylation;microfluidic technology;Microfluidics;Minority;Modification;Molecular;Mutation;Nature;Needle biopsy procedure;Neoplasm Circulating Cells;Neoplasm Metastasis;Neurosecretory Systems;new therapeutic target;novel therapeutic intervention;Oils;particle;Patients;Pattern;Phase;Phenotype;Play;Pre-Clinical Model;precision medicine;Preparation;preservation;Primary Neoplasm;Procedures;Process;promoter;prospective;protein complex;Proteins;Protocols documentation;Reaction;Reagent;Recovery;Research Personnel;Research Technics;Role;Sampling;Science;Solid Neoplasm;Speed;stem;success;Surface;Surface Tension;targeted treatment;Techniques;Technology;therapeutic target;therapy resistant;Translations;tumor;Tumor Cell Invasion;tumor DNA;tumor heterogeneity;tumor progression;tumorigenesis;validation studies;Variant;virtual;Wettability

PROJECT_TITLE: Enhancing Epigenetic Analysis Of Rare Cells With Multi-Phase Microfluidics

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ORG_CITY: BOSTON

PHR: NARRATIVE. The Harvard Aging Brain Study is a longitudinal study aimed at improving our understanding of brain aging and the earliest (preclinical) stages of Alzheimer’s disease. This study acquires imaging data to detect early brain changes related to Alzheimer’s disease, including amyloid plaques and tau tangles, as well as functional and structural imaging data, and detailed assessments of memory and other cognitive processes. Our ultimate goal is to provide knowledge that will accelerate progress towards the successful prevention of cognitive decline due to Alzheimer’s disease.

PI_NAMEs: JOHNSON, KEITH A.;SPERLING, REISA A. (contact)

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: abeta accumulation;Acceleration;Age;Age related pathologies;aged;aging brain;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid;Amyloid beta-Protein;analytical tool;Anatomy;Biological;Biological Markers;biological sex;Blood;Blood Vessels;blood-based biomarker;Brain;Clinical;Clinical Trials;clinically significant;Cognitive;Cognitive aging;cognitive change;cognitive process;cognitive testing;cohort;Cohort Studies;Collaborations;Complex;Data;Dedications;digital measure;digital technology;Early Diagnosis;Ethnic Origin;follow-up;Functional disorder;Functional Imaging;Funding;Goals;Grant;Image;Impaired cognition;Impairment;improved;in vivo;Individual;innovative technologies;insight;International;Knowledge;Leadership;Learning;Longitudinal Studies;Measures;Memory;Methods;multidisciplinary;Multimodal Imaging;Nerve Degeneration;nerve injury;neurobehavioral;Neurofibrillary Tangles;neuroinflammation;novel;Older Population;Outcome;Participant;Pathology;Pattern;Phase;Phenotype;Physical activity;Population;Positron-Emission Tomography;pre-clinical;preclinical study;Predisposition;Prevention;Prevention trial;preventive intervention;Program Research Project Grants;protective factors;Publications;Publishing;rapid detection;Reporting;Research;Research Personnel;resilience;Risk;Risk Factors;Role;Senile Plaques;serial imaging;Socioeconomic Status;Sorting;Stimulus;structural imaging;Surface;Synapses;synaptic function;systemic inflammatory response;tau aggregation;tau Proteins;Technology Assessment;Testing;time interval;tool;Tracer;trial design;Vascular Diseases;Work

PROJECT_TITLE: Impact of Amyloid and Tau on the Aging Brain: The Harvard Aging Brain Study


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: SPERLING, REISA A. (contact)

PROJECT_TERMS: Administrator;Aging;aging brain;Agreement;Alzheimer's Disease;Amyloid;Annual Reports;authority;Autopsy;Biological Markers;biomedical imaging;Budgets;Clinical;Clinical Data;Clinical Trials;Cohort Studies;Collaborations;Communication;Communities;Data;data access;data exchange;data integrity;data quality;data sharing;design;Documentation;Ensure;Expenditure;Funding;Future;General Hospitals;Goals;Human;Human Resources;Image;Impaired cognition;improved;Institution;Institutional Review Boards;International;Knowledge;Leadership;Manuscripts;Massachusetts;meetings;Monitor;multidisciplinary;neuropathology;normal aging;organizational structure;Paper;Participant;Pathology;Persons;Plasma;Positron-Emission Tomography;posters;pre-clinical;Preparation;Prevention trial;Principal Investigator;Procedures;Productivity;Program Research Project Grants;programs;Progress Reports;Publications;quality assurance;Radiation;Radiopharmaceuticals;Remunerations;Reproducibility;Research;Research Personnel;Research Project Grants;research study;Resources;Safety;Sampling;tau Proteins;tool;Travel;United States National Institutes of Health;Work

PROJECT_TITLE: Core A: Administrative Core


NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: The proposed research is relevant to public health because elucidation of GLI1 regulation and anti-GLI1 therapeutic strategies for SMARCA4-deficient lung cancer may lead to novel and more effective treatments for patients. Therefore, the research is relevant to the goal of NIH to foster research strategies and their application to protect and improve human health.

PI_NAMEs: KIM, JAMES  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: 3-Dimensional;antagonist;Arsenic Trioxide;ATP phosphohydrolase;BCL1 Oncogene;BCL2 gene;BCL2L1 gene;Biological Assay;BRD2 gene;Cancer cell line;Cancer Patient;cancer type;candidate marker;Cell Death Induction;Cell Line;checkpoint therapy;chemotherapy;chromatin immunoprecipitation;Chromatin Remodeling Factor;Chronic Myeloid Leukemia;Circular Dichroism;Clinical;Complex;Data;DNA Binding;effective therapy;Embryo;Enhancers;Erinaceidae;experimental study;FDA approved;Fibroblasts;Fostering;Genes;Genetic;Genetic Transcription;GLI gene;GLI3 gene;Goals;Growth;HDAC1 gene;Health;helicase;Histone Deacetylase;Histone Deacetylation;Homology Modeling;Human;improved;inhibitor;insight;knock-down;KRASG12D;Ligation;Literature;loss of function;loss of function mutation;Lung Adenocarcinoma;lung cancer cell;Lysine;Malignant neoplasm of anus;Malignant neoplasm of lung;Malignant neoplasm of testis;Malignant Neoplasms;MCL1 gene;Missense Mutation;Modeling;mouse model;Mus;mutant;mutant mouse model;Mutation;new therapeutic target;Non-Small-Cell Lung Carcinoma;Nonsense Mutation;novel;novel therapeutics;Nucleic Acid Regulatory Sequences;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;pharmacologic;predictive marker;Prognosis;promoter;Proteins;Public Health;Quality of life;Regimen;Regulation;Reporting;Repression;Research;research clinical testing;Signal Pathway;small hairpin RNA;SMARCA4 gene;targeted agent;Testing;The Cancer Genome Atlas;Therapeutic;therapeutic biomarker;therapeutic candidate;therapeutic evaluation;Therapeutic Intervention;therapeutic target;Toxic effect;transcription factor;treatment response;tumor growth;Tumor Suppressor Proteins;United States National Institutes of Health;Up-Regulation

PROJECT_TITLE: Regulation of GLI1, a synthetic lethal target of SMARCA4-deficiency, in lung adenocarcinoma

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Burden of Illness;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Prevention;Serious Mental Illness;Suicide;Violence Research

ORG_CITY: PALO ALTO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: PALO ALTO UNIVERSITY

PHR: 8. Project Narrative The comorbidity between posttraumatic stress disorder and borderline personality disorder (PTSD-BPD) is a serious public health concern characterized by high suicide risk, healthcare utilization, and economic burden. This project examines a brief, target-informed, integrative treatment for individuals with this comorbidity, in efforts to improve accessibility beyond current emerging treatments which are lengthy, resource-intensive, and challenging to implement. Findings from this investigation have high potential for therapeutic reach by providing a briefer treatment alternative to facilitate implementation efforts in every day practice and ultimately decrease the burden of this public health problem.

PI_NAMEs: KUO, JANICE ROSE (contact);MONSON, CANDICE M.

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: Adopted;Adult;affective neuroscience;Aftercare;alternative treatment;Appointment;Behavior;Behavioral;Borderline Personality Disorder;Case Series;Client;Clinic;Clinical;clinical care;Cognitive;Communities;community setting;comorbidity;Complex;cost;Coupled;Diagnosis;Disease;Dropout;Economic Burden;effectiveness evaluation;effectiveness trial;emotion dysregulation;Emotional;Emotional disorder;Employment;Family;follow-up;Frequencies;Functional impairment;health care service utilization;healthcare burden;Hospitalization;Impaired cognition;implementation efforts;implementation facilitation;improved;Individual;innovation;Integrative Therapy;Intervention Trial;Interview;Investigation;Investigational Therapies;Knowledge;Manuals;Measures;Mental Health;Modeling;Monitor;Morbidity - disease rate;neuroimaging;non-suicidal self injury;Outcome;Outpatients;Overutilization of Health Services;Participant;Patient Self-Report;Performance;Phase;Physiological;Population;Post-Traumatic Stress Disorders;primary outcome;Procedures;Protocols documentation;psychosocial;Public Health;Randomized, Controlled Trials;Research;Research Project Grants;Resources;Risk;Risk Management;Safety;satisfaction;secondary outcome;service delivery;Severities;standard care;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Testing;Therapeutic;Time;treatment site;trial design

PROJECT_TITLE: A PILOT EFFECTIVENESS TRIAL OF COGNITIVE PROCESSING THERAPY AUGMENTED WITH SUICIDE RISK MANAGEMENT FOR INDIVIDUALS WITH COMORBID PTSD AND BPD


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Genetics;Human Genome;Neurosciences

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Narrative: Modulation of behavioral responses is a fundamental process, yet the underlying molecular mechanisms are poorly understood. This proposal aims takes a phenotype based molecular genetic approach using genetic mutants to determine the molecular and neural circuits mechanisms underlying a simple learning behavior. and to determine the molecular identity of six zebrafish mutants with defects in habituation of the acoustic startle response. Altered startle habituation have been linked to several cognitive disorders, autism and attention deficit hyperactive disorders.

PI_NAMEs: GRANATO, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Acoustics;Adaptor Signaling Protein;Address;Alleles;Animals;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior;Behavioral;Behavioral Assay;behavioral phenotyping;behavioral plasticity;behavioral response;bioinformatics pipeline;Brain;Calcium Channel;cell type;Characteristics;Clathrin;Cloning;Cognition Disorders;Cognitive;Collection;Complex;CRISPR/Cas technology;Critical Pathways;Data Set;Defect;Endocytosis;Exhibits;experimental study;Gene Expression;gene interaction;Gene Mutation;Genes;Genetic;genetic approach;Genetic Screening;genome sequencing;habituation;hindbrain;Hip region structure;Human;human disease;Huntington gene;Image;imaging approach;Impairment;in vivo;Invertebrates;Knock-out;Larva;learned behavior;Learning;Link;Mammals;Manuals;Measures;Mediating;Metalloproteases;Molecular;Molecular Analysis;Molecular Genetics;molecular modeling;Morphology;mutant;Nervous System;neural;neural circuit;Neurons;neuropsychiatric disorder;novel;palmitoylation;Pathway interactions;Pattern;Performance;Pharmacogenetics;pharmacologic;Pharmacology;Phenotype;Population;prepulse inhibition;Probability;Process;Proteins;receptor;receptor mediated endocytosis;Resolution;response;Role;screening;Sigma Factor;Signal Pathway;Site;small molecule libraries;Startle Reaction;Stereotyping;Stimulus;success;Synapses;synaptic function;System;tool;Transferase;Transgenic Organisms;Vertebrates;voltage;whole genome;Zebrafish

PROJECT_TITLE: Cellular and molecular analysis of startle modulation

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

PI_NAMEs: RENTZ, DORENE MAY (contact)

PROJECT_TERMS: Activities of Daily Living;adjudication;Age;Age Years;aging brain;Alzheimer's Disease;Amyloid;Area;Autopsy;behavior test;Biological;Biological Markers;blind;Blood specimen;Blood Vessels;Boston;Brain;Clinic;Clinical;Clinical assessments;Clinical Data;Clinical Investigator;Cognition;Cognitive;cognitive testing;cohort;Cohort Studies;computerized;Consensus;Data;Data Collection;data exchange;Databases;Dedications;Dementia;Diagnosis;Ensure;ethnic diversity;Evaluation;Event;experience;follow-up;Genetic study;Gifts;Goals;Grant;Heterogeneity;Home;Home environment;Human Resources;Image;Imaging Techniques;Impaired cognition;improved;Individual;Latina;Latino;Latinx;Liquid substance;Longitudinal cohort;Massachusetts;Measurement;Measures;Minority;Minority Groups;Monitor;Moods;multidisciplinary;Neurologic Examination;Neurology;neuropathology;neuropsychiatry;Neuropsychology;Newsletter;Older Population;Participant;Pathology;Physical activity;Physical Examination;Procedures;Program Research Project Grants;Quality Control;Quality of life;Questionnaires;recruit;Research;Research Assistant;Research Personnel;retention rate;Role;Sampling;Schedule;Seasons;Self Administration;social engagement;socioeconomics;Spinal Puncture;symposium;tau Proteins;Telephone;Training;Travel;Underrepresented Minority;Update;Visit;Work;Writing

PROJECT_TITLE: Clinical Core (Core B)


NIH_SPENDING_CATS: Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Transplantation

ORG_DEPT: OTHER BASIC SCIENCES

PHR: Project Narrative Hematopoietic stem cells (HSCs) are rare cells within human bone marrow that are responsible both for the life-long replenishment of all blood cell lineages and for the curative effects of bone marrow transplantation. The creation of human induced pluripotent cells holds great promise for cellular regeneration therapies, but we cannot currently instruct these cells to specifically generate HSCs in vitro. The overall goal of this application is to determine the molecular cues and behaviors that instruct HSC fate in the vertebrate embryo and from human pluripotent stem cells such that these events may ultimately be replicated routinely to generate patient- specific HSCs for clinical utility.

PI_NAMEs: TRAVER, DAVID  (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Ablation;Activities of Daily Living;Anemia;Aorta;Area;Autoimmunity;Behavior;Blood;Blood Cells;Bone Marrow;Bone Marrow Transplantation;Candidate Disease Gene;Cell Communication;Cell Count;Cell Differentiation process;Cell Lineage;Cell Maturation;cell motility;Cell Physiology;cell regeneration;Cell Reprogramming;Cell Therapy;cell type;Cells;Clinic;Clinical;Cues;Derivation procedure;Development;Developmental Biology;differentiation in vitro;differentiation protocol;directed differentiation;Disease;Dissection;Dorsal;effective therapy;Embryo;Embryonic Development;Endothelial Cells;Endothelium;Engineering;Event;experimental study;Generations;Goals;Hematological Disease;Hematopoietic;hematopoietic stem cell emergence;hematopoietic stem cell fate;hematopoietic stem cell niche;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hematopoietic System;hemogenic endothelium;Human;human induced pluripotent stem cells;human pluripotent stem cell;human stem cells;Image;Immune;Immunocompromised Host;improved;In Vitro;in vivo;Instruction;Lateral Mesoderm;leukemia;Life;Medicine;Methods;migration;Molecular;Motivation;Mus;Notch Signaling Pathway;novel;Paraxial Mesoderm;Pathway interactions;Patients;Pattern;pluripotency;Pluripotent Stem Cells;Population;Process;programs;Property;Protocols documentation;reconstitution;regenerative therapy;Research;Research Personnel;Role;screening;Signal Transduction;single cell sequencing;Somites;somitogenesis;Source;stem cell biology;Stem Cell Development;System;Testing;Therapeutic;Tissue Engineering;transcriptome;Translating;Transplantation;transplantation therapy;vertebrate embryos;WNT Signaling Pathway;Zebrafish

PROJECT_TITLE: Molecular and functional dissection of the zebrafish hematopoietic stem cell niche

STUDY_SECTION: MCH

STUDY_SECTION_NAME: Molecular and Cellular Hematology Study Section[MCH]