ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Mental Health;Prevention;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: Aurora

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE This research will address the evolving drug overdose epidemic by elucidating the complexities of polysubstance use among the general adult population and identifying the associated risk profiles. The findings will be particularly relevant for determining critical windows of changing risk or resilience to drug use across the life span. We will evaluate the predictive value of community and societal factors to inform future prevention, treatment, and public health initiatives to improve individuals’ health.

PI_NAMEs: ROCKHILL, KARILYNN  (contact)

PROGRAM_OFFICER_NAME: CREAMER, MELISA RAY

PROJECT_TERMS: Address;Adult;Age;Behavior;Behavioral;Benzodiazepines;Caring;Cessation of life;Classification;Communities;community-level factor;Complex;Data Sources;Death Rate;Diagnosis;Dimensions;Drug abuse;drug development;Drug usage;drug use behavior;Drug user;Epidemic;experience;Family;follow-up;Future;General Population;Glean;Goals;Health;Health Services Accessibility;Healthcare;high risk population;improved;indexing;Individual;Insurance Coverage;Intervention;Law Enforcement;Life;Life Experience;life span;Measures;Medical;Mental Health;Nature;novel;Opioid;opioid use disorder;Overdose;overdose death;overdose risk;Pattern;Peer Pressure;Persons;Pharmaceutical Preparations;polysubstance use;Population;population survey;Predictive Factor;predictive modeling;Predictive Value;Prevalence;Prevention;Psyche structure;psychostimulant;Psychotropic Drugs;Public Health;random forest;Recording of previous events;Recreation;Recreational Drugs;Research;resilience;Respondent;Risk;Risk Factors;social stigma;Societal Factors;stimulant use;Substance Abuse Detection;substance use;Substance Use Disorder;Surveys;Testing;Time;traumatic event;United States;Work;young adult

PROJECT_TITLE: Polysubstance Drug Use in the General Population: Present Day Behaviors, Critical Windows, and Predictors of Psychoactive Drug Use

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Behavioral and Social Science;Clinical Research;Health Services;Lung;Mental Health;Patient Safety;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Clinician burnout—particularly in ICUs—has persisted, despite widespread recognition of this problem. This study will yield valuable information about a crucial missing piece of the puzzle: how organizational factors contribute to burnout in ICU clinicians and adverse, preventable outcomes in patients with acute respiratory failure. By generating novel evidence about the factors that promote organizational resilience in ICUs, the study will lead to improvements in quality of care for patients with acute respiratory failure.

PI_NAMEs: BUCHBINDER, MARA HELENE;COSTA, DEENA KELLY (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: acute care;Acute respiratory failure;Address;Administrator;Adult;adverse outcome;Affect;Attention;Buffers;burnout;care outcomes;Caring;Chronic;Communication;Community Hospitals;Complex;coping;COVID-19 pandemic;cultural health;Data;data modeling;Depersonalization;Development;Electronic Health Record;Employee Health;Engineering;Ensure;Equipment and supply inventories;exhaustion;experience;Fatigue;Focus Groups;Future;Goals;Health;health care settings;Healthcare;Healthcare Systems;Hospitals;improved;improved outcome;Individual;instrument;Intensive Care Units;Intervention;Interview;Measures;Mechanical ventilation;Medical;Medicine;Methods;mindfulness;mortality;mortality risk;multilevel analysis;National Heart, Lung, and Blood Institute;neglect;novel;novel strategies;Nurses;Occupational;Operative Surgical Procedures;Organization administrative structures;Outcome;Pathway Analysis;Patient Care;Patient-Focused Outcomes;Patients;peer;Perception;Performance;Performance at work;Personal Satisfaction;Physicians;Policy Maker;prevent;professional atmosphere;promote resilience;Quality of Care;Relaxation Therapy;Reporting;Research;Research Design;Research Personnel;resilience;resilience scale;Resources;respiratory;Risk Reduction;Role;Safety;Sampling;Severity of illness;Shapes;skills;Stress;stressor;Structure;success;Surgical Intensive Care;Surveys;System;Testing;Time;United States National Academy of Sciences;Ventilator;Work;Workplace

PROJECT_TITLE: Organizational resilience: A novel strategy for improving ICU outcomes

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: DOVER

ORG_DEPT: BIOLOGY

ORG_NAME: DELAWARE STATE UNIVERSITY

ORG_STATE: DE

PHR: Public Health Relevance Today’s biomedical researchers represent the backbone of innovation that improves public health nationwide. However, they have little resemblance to the America’s increasingly diverse populations which contributes to disparities in health access and outcomes. The proposed project to establish a G-RISE site at Delaware State University (DSU) will promote diversity of the new workforce in biomedical research. Being a Historically Black University, DSU is well positioned to significantly contribute towards this goal as its Neuroscience PhD program graduates are 60% among minorities underrepresented in the biomedical research workforce.

PI_NAMEs: HARRINGTON, MELISSA A (contact);KIM, YONGHWAN

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TITLE: G-RISE at Delaware State University: Diversifying neuroscience through predoctoral training at an HBCU

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Immunization;Immunotherapy;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Narrative The goal of this proposal is to investigate the molecular mechanisms regulating the development of protective CD8 T cell immunity in the respiratory tract during influenza infection. We plan to elucidate the molecular cues, signaling pathways, transcriptional regulation and metabolic control of the development, maintenance and function of anti-influenza tissue-resident memory T cells (TRM). We expect our study will help to design future interventions to promote TRM protective function and long-term maintenance in the lung, which ultimately will aid the design of future influenza therapeutics and/or vaccines.

PI_NAMEs: SUN, JIE  (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: Adult;anti-influenza;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Child;cross reactivity;Cues;cytokine;cytotoxic CD8 T cells;Data;design;Development;Epigenetic Process;epigenetic profiling;fitness;Funding;Future;future pandemic;GADD45B;Gene Expression Profiling;Generations;Genetic Transcription;global health;Goals;Grant;Health;Human;Immunity;Immunologic Memory;inducible Cre;Influenza;influenza infection;Influenza Therapeutic;Influenza vaccination;influenza virus vaccine;influenzavirus;Intervention;Lower Respiratory Tract Infection;Lung;Maintenance;MAP3K7 gene;Mediating;Memory;Metabolic;Metabolic Control;Mitochondria;mitochondrial fitness;mitochondrial metabolism;Molecular;Molecular Target;mouse model;novel;pandemic influenza;pathogen;Pathway interactions;Persons;Play;Prevention;Probability;Receptor Signaling;Regulation;Reporting;Research;Respiratory System;Role;Signal Pathway;Signal Transduction;T cell response;T memory cell;T-Cell Development;T-Lymphocyte;therapeutic vaccine;tissue resident memory T cell;Tissues;transcription factor;Transcriptional Regulation;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;Transgenic Mice;Upper Respiratory Infections;Vaccines

PROJECT_TITLE: Molecular regulation of protective CD8 immunity against influenza infection

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Regenerative Medicine

ORG_CITY: RICHMOND

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: NARRATIVE Aligned collagen fibers are the primarily source of strength in tendons, ligaments, and menisci; however these fibers do not regenerate after injury, nor in engineered replacements, creating a lack of repair options. There is a need to regenerate these collagen fibers to develop functional repairs and replacements for tissues throughout the body. Using a novel culture system, we will investigate how cells sense and response to mechanical cues in developing collagen fibers so to better engineer functional ligament replacements and to drive repair in the body after injury.

PI_NAMEs: PUETZER, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Actomyosin;cell growth regulation;Cells;cellular development;Chemicals;Cicatrix;clinically relevant;Closure by clamp;Collagen;Collagen Fiber;Collagen Fibril;crosslink;Cues;Cytoskeleton;density;Development;Devices;Diameter;Embryo;Engineering;Environment;Fascicle;Fiber;Fibroblasts;Focal Adhesion Kinase 1;Gel;Goals;Human;In Vitro;in vivo;Individual;Injury;insight;Integrins;Ion Channel;Knowledge;Length;Ligaments;loss of function;mechanical signal;Mechanical Stimulation;Mechanics;mechanotransduction;Meniscus structure of joint;meter;Methods;Mobility decline;mouse model;Musculoskeletal;Natural regeneration;Neonatal;novel;Pain;Periodicity;Piezo 1 ion channel;Play;postnatal;Proteoglycan;Protocols documentation;Rehabilitation therapy;repaired;replacement tissue;response;restraint;Role;sensor;Signal Pathway;Signal Transduction;Source;Stretching;Surface;System;Tendon structure;therapeutic target;Tissue Engineering;tissue regeneration;Tissues;Translating;transmission process;Work

PROJECT_TITLE: Unraveling the Mechanism of Mechanotransduction in Hierarchical Collagen Fiber Formation

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

PHR: OEF/OIF/OND Veterans face an unprecedented array of combat-related disabilities. Referred to as polytraumatic injuries, these impairments often include traumatic brain injury, PTSD, chronic pain, and depression. Veterans with polytraumatic injuries struggle with community reintegration and psychosocial functioning, leading to high rates of unemployment, poor health outcomes, and increased risk for substance abuse and suicide. To date, however, there has yet to be a systematic investigation of the role of nutrition in psychosocial recovery. Our work, therefore, aims to operationalize and develop a theoretically grounded, empirically validated outcome measure of “nutritional functioning”. Additionally, as integrative health modalities are increasingly popular among injured OEF/OIF/OND Veterans, we will conduct our research in Whole Health and Rehabilitation settings. A unique cohort requires innovative approaches, and our project will address the VHA’s overarching goal of improving psychological recovery in Veterans with polytrauma.

PI_NAMEs: BROSTOW, DIANA  (contact)

PROJECT_TERMS: Address;Affect;Anxiety;Awareness;Behavior;Belief;care providers;care systems;Caring;Characteristics;chronic pain;Classification;Clinical;Clinical Trials;cognitive capacity;cohort;combat;community reintegration;Complex;Country;Data;Development;dexterity;Dimensions;disability;Economics;Elements;Encapsulated;Enrollment;Environmental Risk Factor;experience;Face;feeding;Food;food insecurity;food security;Freedom;functional disability;Future;Goals;Health;health care model;Health Status;Healthcare;Impairment;improved;Income;Individual;injured;Injury;innovation;Integrative Medicine;internalized stigma;International;Intervention;Interview;Investigation;Knowledge;Learning;Life;Literature;Location;Maintenance;Measurement;Measures;Medical center;Meditation;Mental Depression;mental function;Methods;mindfulness-based stress reduction;Modality;Modeling;Multiple Trauma;novel strategies;nutrition;Nutritional;operation;Outcome;Outcome Measure;Perception;Personal Communication;Persons;Physical Capacity;Physical Function;Physical Rehabilitation;poor health outcome;Population;Post-Traumatic Stress Disorders;Poverty;Process;Property;Provider;psychologic;psychological distress;Psychometrics;psychosocial;Psychosocial Factor;randomized, clinical trials;Recording of previous events;Recovery;Recovery of Function;rehabilitation service;Rehabilitation therapy;rehabilitative care;Reporting;Research;Research Personnel;Restaurants;Risk;Risk Factors;Role;Sampling;Services;Shapes;Social Functioning;Societies;statistics;Stigmatization;Substance abuse problem;substance use;Suggestion;suicidal behavior;Suicide;Symptoms;therapy design;Training;Traumatic Brain Injury;Unemployment;Validation;validation studies;Veterans;Veterans Health Administration;whole health;Work

PROJECT_TITLE: "Nutritional Functioning" in OEF/OIF/OND Veterans with Polytraumatic Injuries: Developing a New Approach

STUDY_SECTION_NAME: Career Development Program - Panel II[RRD9]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: CHARLESTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PUBLIC HEALTH RELEVANCE Young people who have experienced traumatic events are much more likely than those who have not had such experiences to acquire HIV and to develop substance use problems, costing the US economy hundreds of billions of dollars. The goal of the proposed research is to refine and evaluate a virtual reality tool to enhance the trauma-informed assessment and prevention of substance use and sexual risk behaviors among young people who have experienced trauma and are at high risk for HIV acquisition. The significantly heightened capacity for mentorship of early stage patient-oriented researchers who will learn about the incorporation of virtual reality technologies with HIV and substance use risk reduction for trauma-exposed young people, along with the numerous other related training experiences gleaned from the candidate's research program in these areas, further enhances the public health importance of the proposed K24 renewal.

PI_NAMEs: DANIELSON, CARLA KMETT (contact)

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: Achievement;addiction;Address;Adolescent;Adolescent Risk Behavior;Adult;AIDS prevention;Area;Award;Behavior;Budgets;Clinic;Clinical;Clinical assessments;Clinical Sciences;Clinical Trials;Complex;cost;Cues;Data;Development;early-career faculty;efficacy evaluation;emotion regulation;Emotions;Environment;Evaluation;experience;Exposure to;Feedback;Focus Groups;Funding;Glean;Goals;Health Personnel;high risk;high risk behavior;high risk population;HIV;HIV risk;HIV Seronegativity;improved;innovation;Instruction;International;Internships;interpersonal trauma;Interview;Knowledge;Learning;lens;lifetime risk;Link;Measures;Mentors;Mentorship;Methods;mHealth;Mid-Career Clinical Scientist Award (K24);Modeling;National Institute of Drug Abuse;new technology;patient oriented;patient oriented research;Persons;physical abuse;Play;Population;Populations at Risk;Postdoctoral Fellow;pre-doctoral;Preparation;Prevention;preventive intervention;Procedures;Process;Productivity;programs;Psychologist;Psychology;Public Health;public health relevance;Publications;Qualitative Research;Reaction;Recommendation;Recording of previous events;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Resources;response;Risk;Risk Assessment;Risk Behaviors;Risk Factors;Risk Reduction;Role;Sampling;Scientist;self reported behavior;Sexual abuse;sexual risk behavior;skills;skills training;Substance abuse problem;substance use;Substance Use Disorder;substance use prevention;substance use treatment;Technology;Teenagers;Time;tool;tool development;Training;training opportunity;Trauma;trauma exposure;traumatic event;traumatic stress;Underrepresented Populations;United States National Institutes of Health;Violence;virtual;virtual reality;virtual reality environment;Work;young adult;young men who have sex with men;Youth

PROJECT_TITLE: Mentorship and Research in HIV and Addiction Prevention Among Traumatized Youth

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Eating Disorders;Mental Health;Mental Illness;Nutrition;Pediatric;Prevention;Substance Misuse;Underage Drinking

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative  Alcohol use disorder and binge eating disorders are debilitating illnesses that often co-occur and develop during late adolescence. College students are particularly at-risk for establishing problematic binge drinking and binge eating patterns that could manifest into full disorders. We seek to develop and test a transdiagnostic approach to target the underlying mechanisms maintaining problematic binge drinking and eating behaviors among students. Developing an evidence-based mobile phone-accessible and personalized intervention that could be scalable to reach thousands of students nationally can help to alleviate personal, familial, and societal costs resulting from binge drinking and binge eating in this population.

PI_NAMEs: MURRAY, STUART B;PEDERSEN, ERIC R. (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: acceptability and feasibility;Address;Adolescence;Adult;Affect;Alcohol consumption;alcohol measurement;alcohol poisoning;alcohol related consequences;alcohol use disorder;American;Anxiety;Behavior;behavior change;Behavioral;behavioral health intervention;binge drinking;Binge Eating;Binge eating disorder;binge type behavior;Bulimia;care seeking;Cellular Phone;Cessation of life;Cognitive;college;Consumption;conventional therapy;Counseling;Coupled;Data;design;Development;Diagnosis;Diagnostic;diagnostic strategy;diagnostic value;Disease;drinking;drinking behavior;Eating Behavior;Eating Disorders;Education;efficacy evaluation;emotion regulation;evidence base;Evidence based intervention;Evidence based practice;Evidence based treatment;experience;Feedback;Female;fighting;Focus Groups;Food;food restriction;Frequencies;Harm Reduction;Healthy Eating;Heavy Drinking;heavy drinking college student;high intensity drinking;high risk sexual behavior;Impairment;Impulsivity;Incidence;Individual;Injury;innovation;Intervention;intervention effect;intervention refinement;Link;male;Medical;Memory;Mental Depression;Methods;Morbidity - disease rate;mortality;Motivation;negative affect;Neurobiology;Obesity;Outcome;Pattern;personalized approach;personalized intervention;Persons;Phase;Phenotype;physical conditioning;pilot test;Population;post intervention;Prevalence;prevent;preventable death;Prevention;Prevention approach;preventive intervention;Procedures;programs;Public Health;Randomized;Randomized, Controlled Trials;recruit;Reporting;Resistance;Resources;Rewards;Risk;screening;secondary outcome;Severities;sex;sexual assault;skills;Social Functioning;societal costs;Students;Symptoms;Testing;Time;Treatment Efficacy;Treatment outcome;university student;women versus men;young adult

PROJECT_TITLE: A Mobile-Based Intervention to Address Heavy Drinking and Binge Eating in College Students

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Pediatric;Pediatric - AIDS;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Based on accumulating data pointing to highly significant shifts in TB-specific antibody glycosylation across latent and active TB disease, the goal of this proposal is to develop an inexpensive, simple, reliable TB-specific antibody-based point-of-care diagnostic to manage TB disease in children under the age of 5.

PI_NAMEs: BRYSON, BRYAN DAVID (contact)

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: 5 year old;Acceleration;Acute;Adult;Affect;Africa;Age;Antibodies;Antibody Response;Antibody titer measurement;Antigen Targeting;Antigens;Area;Binding;Biological Assay;Biological Markers;biomarker signature;Blood;Cause of Death;Cessation of life;Child;Childhood;Classification;Clinical;co-infection;cohort;Data;Detection;Development;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic Equipment;diagnostic signature;diagnostic strategy;Diagnostic tests;Disease;Drops;Electrical Engineering;Electronics;Enrollment;Epidemic;Exposure to;Failure;Geography;glycosylation;Goals;high risk;HIV;HIV Infections;HIV-exposed uninfected infant;HIV/TB;Immunologist;improved;Individual;Infection;Inflammatory;Link;Machine Learning;Measurement;Measures;microchip;miniaturize;multidisciplinary;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;Nature;novel;pathogen;pediatrician;point of care;point of care testing;point-of-care detection;point-of-care diagnosis;point-of-care diagnostics;Polysaccharides;Population;prenatal exposure;Preparation;prevent;programs;prospective;Pulmonary Tuberculosis;Reporting;Resource-limited setting;response;Sampling;Scheme;Sensitivity and Specificity;sensor;Serology test;Serum;Severities;Shapes;sialylation;South Africa;Specificity;Sputum;Structure;System;Technology;Testing;Time;Translating;Tuberculosis;Tuberculosis diagnosis;tuberculosis treatment;Typhoid Fever;Vaccines

PROJECT_TITLE: Multiplexed Antigen-Specific Antibody Fc Profiling on a Chip for Point-of-Care Diagnosis of TB in HIV-infected Children

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-R(50)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Human Genome;Machine Learning and Artificial Intelligence;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE One outstanding question in addiction biology concerns the mechanism by which neurological changes persist long past the cessation of drug taking. The persistent nature of epigenetic modifications may underlie their role in chronic psychiatric diseases, such as addiction and depression. This proposal aims to define the molecular mechanisms by which a key neuronal transcription factor, Nr4a1, leads to long-term change in gene expression that persist across cocaine abstinence.

PI_NAMEs: HELLER, ELIZABETH A (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Abstinence;addiction;Attenuated;attenuation;Basic Science;Behavior;Behavioral;Binding;Bioinformatics;Biology;Brain;CARTPT gene;Cell Differentiation process;Cell Nucleus;cell type;Chromatin;Chronic;Cleavage Under Targets and Release Using Nuclease;Clustered Regularly Interspaced Short Palindromic Repeats;Cocaine;cocaine craving;Cocaine Dependence;cocaine exposure;cocaine related behaviors;cocaine reward;cocaine seeking;cocaine self-administration;craving;CRISPR interference;CRISPR-mediated transcriptional activation;Data;Data Set;Development;dopaminergic neuron;drug abstinence;Drug Addiction;Drug Exposure;Drug Targeting;Epigenetic Process;epigenetic profiling;experimental study;Extinction;Female;Gene Activation;Gene Expression;Gene Expression Profiling;Genes;Genetic Transcription;genome-wide;histone modification;Histones;Hour;in vivo;Individual;Life;Link;Machine Learning;machine learning method;male;Measures;Mediating;member;Mental Depression;Mental disorders;Methods;Methyltransferase;Modification;Molecular;Mus;Nature;neuroadaptation;Neurologic;Neurons;new therapeutic target;novel;Nuclear Receptors;Nucleus Accumbens;Pathologic;Pharmaceutical Preparations;pharmacologic;Phenotype;Post-Translational Protein Processing;Predisposition;programs;prolonged abstinence;Publishing;rat orphan nuclear receptor NR4A1;recruit;Regulation;Relapse;Repression;Research;Rewards;Role;Sampling;Signal Transduction;small molecule;Substance Use Disorder;Symptoms;Testing;Therapeutic Agents;transcription factor;transcriptome sequencing;translational potential;unsupervised learning;Work

PROJECT_TITLE: Epigenetic mechanisms of sustained transcription across cocaine abstinence

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


ADMINISTERING_IC: EY

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Eye Disease and Disorders of Vision;Prevention

ORG_CITY: CAMBRIDGE

ORG_DEPT: CHEMISTRY

ORG_NAME: HARVARD UNIVERSITY

PHR: PROJECT NARRATIVE As the population ages, cataract lowers vision of millions of Americans every year, requiring costly surgery, and it leads to blindness for millions of others in the developing world where surgery is unaffordable. We have found evidence that cataracts arise from the combination of irreversible destabilizing modifications, reversible oxidative modifications (disulfide bonds), and an unusual “interface stealing” interaction between eye lens crystallin proteins, which together lead to aggregation of these proteins. We will study the biochemical mechanisms and the altered protein structures that underlie this aggregation process and apply this combined knowledge to design aggregation inhibitors that could prevent or delay cataract.

PI_NAMEs: SHAKHNOVICH, EUGENE I (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Acceleration;Address;Affect;Age;Age of Onset;aged;Aging;American;analytical ultracentrifugation;Biochemical;Biochemistry;Biological;Biological Assay;Blindness;C-terminal;Catalysis;Cataract;Chemicals;Chemistry;Collaborations;Computing Methodologies;congenital cataract;cost;Coupled;crosslink;Crystalline Lens;Crystallins;Data;deamidation;design;Development;Disease;disulfide bond;Disulfides;DNA Sequence Alteration;Evolution;Eye Surgeon;FDA approved;Future;gamma-Crystallins;Genetic;Homo;Human;hydrophilicity;improved;in silico;In Vitro;in vitro testing;in vivo;inhibitor;kinetic model;Kinetics;Knowledge;Lead;lens;light scattering;Link;Maps;Mass Spectrum Analysis;mathematical model;Measures;Medical;Methods;migration;Modeling;Modification;Molecular Conformation;Monte Carlo Method;mouse model;mutant;Mutation;N-terminal;non-Native;novel;Operative Surgical Procedures;oxidation;Oxidation-Reduction;Oxidoreductase;Pathway interactions;Patients;Peptides;peptidomimetics;Pharmaceutical Preparations;Physical Chemistry;Physiological;polypeptide;Population;Post-Translational Protein Processing;prevent;Prevention;prion-like;Prions;Process;Property;protein aggregation;Protein Engineering;protein protein interaction;protein structure;Proteins;Proteolysis;Proteomics;rational design;Research;residence;Severities;simulation;Site;solid state nuclear magnetic resonance;Source;Structural Models;Structure;synergism;Temperature;Testing;Theft;Therapeutic;Thermodynamics;Time;Tissues;United States National Institutes of Health;Variant;Visual impairment;Work

PROJECT_TITLE: Structure and Interactions of Conformational Intermediates in gamma-D Crystallin Aggregation, and Their Targeting for Cataract Prevention

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Nanotechnology;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: AMHERST

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: PROJECT NARRATIVE There is a need for an effective vaccine that blocks the transmission of malaria. We will design a vaccine by “focusing” the immune response towards the same target epitope of a potent monoclonal antibody against Pfs48/45, an antigen candidate which we recently solved the structure of. The vaccine will be tested in the context of a next-generation vaccine adjuvant we developed which spontaneously converts well-characterized protein antigens into large particles with significantly greater immunogenicity.

PI_NAMEs: JULIEN, JEAN-PHILIPPE ;LOVELL, JONATHAN F (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Acceleration;Adjuvant;Affect;Antibodies;Antibody Response;Antibody titer measurement;Antibody-mediated protection;Antigen Targeting;Antigens;Binding;Biological;Blocking Antibodies;Clinical;Clinical Research;Cobalt;Communication;Complement;Complex;Consumption;Culicidae;density;Dependence;design;Development;Disease;Epitopes;follow-up;Formulation;Future;Germ Cells;glycosylation;Human;Immune response;Immunity;Immunization;immunogenicity;Immunoglobulin G;improved;Interruption;Life;Liposomes;Malaria;malaria transmission;malaria transmission-blocking vaccine;Malaria Vaccines;Masks;Midgut;Modification;Monoclonal Antibodies;Mutation;nanoliposome;Nanotechnology;Nature;next generation;NIH Program Announcements;novel vaccines;Parasites;particle;Phospholipids;Plasmodium falciparum;Population;Porphyrins;preclinical toxicity;Production;Proteins;Publishing;rational design;Recombinants;Reproduction;Research;Resources;response;Risk;Safety;Serum;Structure;System;Technology;Testing;three dimensional structure;Time;Toxic effect;Toxin Conjugates;transmission blocking;transmission process;transmission-blocking vaccine;Vaccination;Vaccine Adjuvant;Vaccine Antigen;vaccine candidate;vaccine discovery;vaccine efficacy;vaccine-induced antibodies;Vaccines;Viral Vector;Virus-like particle;World Health Organization

PROJECT_TITLE: Rationally-Designed, Spontaneous-Particleized Pfs48/45 for a Multivalent Malaria Vaccine

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Hematology;Human Genome;Microbiome;Networking and Information Technology R&D (NITRD);Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Graft vs. host disease (GVHD) remains a major barrier for the successful application of hematopoietic stem cell transplant for a wide range of benign and hematologic malignancies. There is increasing evidence that the microbiome can impact GVHD outcomes, though current understanding of how specific microbial species contribute to GVHD pathogenesis remains largely correlative with limited mechanistic insights. The proposed research will aim to improve the understanding of how the microbiota and microbiota-specific T cell response impact the alloreactive response to open additional strategies aimed at treating GVHD.

PI_NAMEs: YEH, ALBERT CHIA-CHUN (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Acute Graft Versus Host Disease;Address;Allogenic;alpha-beta T-Cell Receptor;Antigenic Specificity;Antigens;antimicrobial;Benign;Binding;Biochemical;career development;CD4 Antigens;CD4 Positive T Lymphocytes;Cellular Immunity;Clinical;Clonal Expansion;Cloning;combinatorial;commensal microbes;Computational algorithm;Computer Models;Computing Methodologies;Coupled;Data;Data Set;differential expression;Disease Outcome;Donor Selection;Ecosystem;Epithelial Cells;Epitopes;experience;experimental study;Face;Foundations;Fred Hutchinson Cancer Research Center;Gastrointestinal tract structure;Gene Expression;Genetic;Genome;Genomics;graft vs host disease;gut microbiome;gut microbiota;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;High Prevalence;Homeostasis;Hybridomas;Immune response;Immunologic Surveillance;Immunologics;improved;in vivo;Inflammatory Bowel Diseases;Injury;insight;instructor;intestinal epithelium;Ligands;Low Prevalence;machine learning prediction;Mediating;Medicine;Mentors;microbial;microbial composition;microbiome;microbiota;microbiota composition;microorganism antigen;Minor;Modeling;Molecular Mimicry;Morbidity - disease rate;mortality;Mus;novel;Outcome;Pathogenesis;Pathogenicity;Pathology;Peptides;Phenotype;Physicians;Physiological;Play;post-transplant;Postdoctoral Fellow;Program Development;protein aminoacid sequence;Proteins;Research;Resolution;response;Role;Sampling;Scientist;screening;sequencing platform;Severities;Shapes;Shotguns;single cell sequencing;single-cell RNA sequencing;skills;Source;Specificity;Stem cell transplant;System;T cell reconstitution;T cell response;T-Cell Activation;T-Lymphocyte;TCR Activation;Testing;Training;transcriptomics;transplant model;Transplantation;Universities;Washington;whole genome;Work

PROJECT_TITLE: Propagation of graft vs. host disease through CD4+ T-cell cognate recognition of gastrointestinal microbiota

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


ADMINISTERING_IC: HD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SANTA BARBARA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: Narrative  During their development, cells that are initially non-specialized undergo differentiation, causing them to commit to particular identities and to endow them with the properties necessary to perform their unique functions. We propose to reveal the genetic and molecular processes that cause cells to lock onto particular differentiated, specialized identities and will investigate how cells can be provoked to switch to entirely different identities. The findings from these studies could lead to methods for creating replacement tissues and organs in regenerative medicine, will contribute to our understanding of malformed organs in birth defects, and may provide important information about particular cancers of the digestive tract.

PI_NAMEs: ROTHMAN, JOEL H. (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Adult;adult stem cell;Animals;Architecture;ATAC-seq;attenuation;Autophagocytosis;Auxins;Binding;Biological;Caenorhabditis elegans;causal variant;Cell Cycle;Cell Cycle Inhibition;Cell Differentiation process;Cell Nucleus;cell type;Cells;Characteristics;Chromatin;Code;Congenital Abnormality;Data Pooling;Development;developmental plasticity;Elasticity;Embryo;Endoderm;Endowment;Event;Extinction;Gastrointestinal tract structure;Gene Expression;Gene Expression Profile;Generations;Genes;Genetic;genetic selection;Genetic Transcription;genome-wide;Genomics;Germ Cells;Goals;Gonadal structure;Hand;Heat-Shock Response;Human;human stem cell-derived;in vivo;insight;Maintenance;malformation;Malignant Neoplasms;Mediating;member;Metaplasia;Methods;Molecular;Morphology;multiple omics;mutant;Mutation;Nature;Nuclear;Organ;pathogen;Pathway interactions;Pattern;Pharyngeal structure;postmitotic;Predisposition;premalignant;prevent;Process;Program Development;Property;protein degradation;Proteins;Recovery;Refractory;Regenerative Medicine;replacement tissue;Research;Resistance;response;Role;Specific qualifier value;Statistical Data Interpretation;Stereotyping;System;Testing;transcription factor;transcriptome;transdifferentiation;Untranslated RNA;Up-Regulation;Uterus;Variant;whole genome

PROJECT_TITLE: Developmental reprogramming and transorganogenesis

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Methamphetamine;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stimulant Use and Misuse;Substance Misuse

ORG_DEPT: PATHOLOGY

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Project Narrative This project will validate and establish a clinically relevant in vitro brain model for NeuroAIDS research in the context of drug abuse.

PI_NAMEs: HO, WENZHE  (contact);HU, WENHUI

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: Acute;acute infection;AIDS prevention;Astrocytes;Autopsy;Biological Assay;Biological Models;Biopsy;Brain;brain cell;Cell Line;cell type;Cells;Central Nervous System;Cerebrum;Chronic;chronic infection;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;confocal imaging;Development;DLG4 gene;DNA;Drug abuse;drug of abuse;Enzyme-Linked Immunosorbent Assay;experience;Feasibility Studies;Flow Cytometry;GAG Gene;Generations;Glial Fibrillary Acidic Protein;Growth;HIV;HIV Infections;HIV-associated neurocognitive disorder;Human;human induced pluripotent stem cells;human model;Immunohistochemistry;In Vitro;Individual;induced pluripotent stem cell;Inflammasome;interest;ITGAM gene;Label;Macrophage;MCM2 gene;Methamphetamine;methamphetamine abuse;methamphetamine effect;methamphetamine use;methamphetamine user;Methods;Microglia;Modeling;Molecular;National Institute of Drug Abuse;Natural Immunity;Nature;nerve stem cell;nestin protein;neuroAIDS;neurogenesis;neuron apoptosis;neuronal circuitry;neuronal survival;Neurons;neurotropic;Opioid;Organ;Organoids;Pathogenesis;Patients;Peripheral;Physiological;Protocols documentation;psychostimulant;reactivation from latency;Reproducibility;Research;RNA;Role;success;synaptogenesis;Synaptophysin;synaptotagmin;United States;Virus;Western Blotting;Work

PROJECT_TITLE: HIV, Methamphetamine and Human iPSC-derived Microglia-containing Cerebral Organoids


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Nutrition;Obesity

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Cold exposure and mitochondrial stress induce the integrated stress response (ISR) in brown adipose tissue (BAT), resulting in the activation of the activating transcription factor 4 (ATF4). This proposal will elucidate the role of the unfolded protein response (UPR) kinase PERK on ATF4 activation, and will determine whether ATF4 is required and sufficient for the systemic metabolic adaptations to cold exposure and mitochondrial stress, via the secretion of growth and differentiation factor 15 (GDF15), as a batokine.

PI_NAMEs: PEREIRA ALAMBERT, RENATA  (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: activating transcription factor 4;Acute;Adipocytes;Adipose tissue;Adrenergic Agents;Affect;biological adaptation to stress;Body Temperature;Brown Fat;Cardiovascular Diseases;cardiovascular health;Chemicals;Chimeric Proteins;combat;comorbidity;Data;design;Diabetes Mellitus;diet-induced obesity;Disease;Endocrine;Endoplasmic Reticulum;Energy Metabolism;Exhibits;fibroblast growth factor 21;Generations;Genetic;growth differentiation factor 1;Growth Factor;hindbrain;Homeostasis;improved;In Vitro;in vivo;Injections;Knockout Mice;Lead;Mediating;Metabolic;metabolic fitness;Metabolism;Mitochondria;Mitochondrial Proteins;Molecular;morphogens;mouse model;Mus;Nerve Growth Factor Receptors;new therapeutic target;novel;novel therapeutic intervention;Obesity;obesity treatment;Optic atrophy 1;overexpression;Pathway interactions;pharmacologic;Phosphotransferases;Physiological;Physiology;Play;protective effect;protein activation;Protein Inhibition;Protein Kinase;protein kinase R;Proteins;receptor;Resistance;Respiration;response;Role;Signal Transduction;Stimulus;Stress;Testing;Therapeutic;Thermogenesis;Thinness;tool;upstream kinase;Weight Gain

PROJECT_TITLE: The role of the integrated stress response in brown adipose tissue-mediated metabolic adaptations

STUDY_SECTION: IPOD

STUDY_SECTION_NAME: Integrative Physiology of Obesity and Diabetes Study Section[IPOD]


ORG_CITY: INDIANAPOLIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Beige fat cells can consume a large quantity of calories as heat and hold great promise for combating the epidemic of obesity and metabolic disorders. This project will explore a new pathway of beige adipocyte generation, its regulation by a gene called NFIL3, and its effect on whole body energy balance and glucose control. This study will suggest new ways to treat and/or prevent obesity, diabetes and other metabolic diseases.

PI_NAMEs: ROH, HYUN CHEOL  (contact)

PROGRAM_OFFICER_NAME: HAFT, CAROL R

PROJECT_TERMS: Address;Adipocytes;Adipose tissue;Adult;Affinity Chromatography;Attention;Automobile Driving;Binding;Biological Assay;blood glucose regulation;Brown Fat;Calories;Cell Culture Techniques;Cell Differentiation process;cell type;Cells;ChIP-seq;Circadian Rhythms;Classification;comorbidity;conditional knockout;Consumption;Data;Data Analyses;Defect;Desire for food;Development;Diabetes Mellitus;diet-induced obesity;dietary control;disorder control;energy balance;Energy Metabolism;epigenome;epigenomic profiling;epigenomics;Exercise;experimental study;Fatty acid glycerol esters;feeding;Gene Expression;Generations;Genes;Goals;Health;High Fat Diet;Homeostasis;Immune;Immunofluorescence Microscopy;Impairment;improved;In Vitro;in vivo;Intake;Interleukins;Knockout Mice;Mediating;Metabolic;Metabolic Diseases;Methods;Microscopy;Molecular;mouse model;Mus;Nature;new therapeutic target;novel;novel therapeutic intervention;Nuclear;Nutrient;nutrient metabolism;Obesity;Obesity Epidemic;obesity management;obesity prevention;Pathway interactions;Physiologic pulse;Physiology;Population;Predisposition;Process;programs;Proliferating;recruit;Regulation;Research;response;Ribosomes;Role;Route;single nucleus RNA-sequencing;stem-like cell;success;Temperature;therapeutic target;Thermogenesis;transcription factor;Transcriptional Regulation;transcriptomic profiling;transdifferentiation;Transgenic Mice;Translating;United States

PROJECT_TITLE: TRANSCRIPTIONAL REGULATION OF BEIGE ADIPOCYTE CELLULAR PLASTICITY

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Brain Disorders;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative The Brief Research in Interdisciplinary Neurosciences (BRAIN) program offers a rich summer research opportunity at the Vagelos College of Physicians and Surgeons at Columbia University for predoctoral candidates interested in research in the field of aging, particularly among neurologic disorders including neurodegenerative illnesses such as Alzheimer, Parkinson and Lou Gehrig diseases, as well as a broad array of related neuroscience disciplines. This program provides an ideal environment for students to pursue careers in research studying diseases often without cure or even effective treatments, and thus pose a significant public health burden. In addition to researching neurological diseases, students learn essential principles of research at a critical training period, providing skills to launch successful research careers.

PI_NAMEs: AGARWAL, SACHIN ;MANLY, JENNIFER JAIE;NOBLE, JAMES MCCALLUM (contact);PRZEDBORSKI, SERGE E

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Academic Medical Centers;Aging;Alzheimer's disease related dementia;Authorship;Basic Science;Behavioral Research;Biomedical Research;career;Clinical Research;Clinical Trials;collaborative approach;Disease;doctoral student;education research;Educational Curriculum;Epidemiology;Epilepsy;experience;Funding;Institution;Mentors;Motor Neuron Disease;multidisciplinary;Nervous System;Nervous System Disorder;neurogenetics;Neurologic;Neurologist;Neurology;neuropathology;Neuropsychology;Neurosciences;Parkinson Disease;Patients;Positioning Attribute;posters;pre-clinical;pre-doctoral;programs;Reproducibility;Research;Research Methodology;Research Project Grants;Research Training;Resources;responsible research conduct;Site;Stroke;Structure;student participation;Students;summer research;Work

PROJECT_TITLE: Brief Research In Aging and Interdisciplinary Neurosciences (BRAIN)


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Electronic Nicotine Delivery Systems;Infertility;Maternal Health;Nutrition;Pediatric;Physical Activity;Pregnancy;Prevention;Sleep Research;Tobacco;Women's Health Research

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative Ten to 15% of American couples experience infertility and 50% of all infertility is attributable to male factor; however, little is known about predictors of male infertility or how male infertility and other male factors predict subsequent reproductive and perinatal outcomes. The proposed prospective study will identify modifiable risk factors for poor semen quality and examine how male factors influence reproductive and perinatal outcomes, yielding important public health information about male reproductive health.

PI_NAMEs: EISENBERG, MICHAEL L;WISE, LAUREN A (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: actigraphy;adverse birth outcomes;adverse outcome;Agreement;Alcoholic Beverages;American;Area;Behavioral;Beverages;Bicycling;Canada;cigarette smoking;Clinical;cohort;Cohort Studies;Collection;Conceptions;cost effective;Couples;Data;Data Reporting;dietary;electronic cigarette use;Enrollment;epidemiology study;Etiology;experience;Female;Fertility;Fertility Determinant;fitbit;follow-up;Funding;Future;General Population;Gestational Age;Grant;Health;high risk;Home;Infertility;Infrastructure;innovation;Intake;Length;Life Style;Low Birth Weight Infant;male;Male Infertility;marijuana use;Mediating;Medical;men;Metabolism;Methods;modifiable risk;Monitor;National Institute of Child Health and Human Development;North America;nutrition;Online Systems;Outcome;Participant;Pathway interactions;Patient Self-Report;pediatric health outcomes;Perinatal;perinatal outcomes;Physical activity;Pilot Projects;poor sleep;Predictive Factor;Pregnancy;Pregnancy loss;Pregnancy Outcome;Prevalence;Prospective Studies;Public Health;recruit;Reporting;reproductive;Reproductive Health;Research;Research Design;Risk;Risk Factors;Sampling;sedentary lifestyle;Selection Bias;Seminal fluid;Sleep;Sleep Deprivation;Sleep Disorders;sleep quality;sperm cell;Sperm Count Procedure;Sperm Motility;Spontaneous abortion;Strenuous Exercise;study population;Subfecundity;subfertility;sugar;sweetened beverage;Testing;time-to-pregnancy;United States;vaping

PROJECT_TITLE: A prospective study of male factors, fertility, and pregnancy outcomes

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Atherosclerosis;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: LONG BEACH

ORG_NAME: CALIFORNIA STATE UNIVERSITY LONG BEACH

PHR: NARRATIVE This project aims to investigate the role of an innate immune protein, C1q in atherosclerosis / cardiovascular disease. C1q binds “bad cholesterol” and helps macrophage immune cells break it down to be removed from the body, which prevents dangerous plaque build-up. This project will focus on identifying the molecular mechanisms involved to identify novel therapeutic targets for treating atherosclerosis and improving public health.

PI_NAMEs: FRASER, DEBORAH ANN (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: Anti-Inflammatory Agents;Apoptosis;Apoptotic;Arterial Fatty Streak;Atherosclerosis;autocrine;Autoimmune Diseases;Autophagocytosis;Binding;Biological;Biological Assay;Bone Marrow;C1q deficiency;Cardiovascular Diseases;Cell Survival;Cells;Cholesterol;Cholesterol Homeostasis;Chronic;Clinical;Complement;Complement 1q;Complement Activation;complement pathway;cytokine;Cytokine Signaling;Dangerousness;Data;Desmosterol;Development;Disease;Disease Progression;Environment;Enzymes;Excision;Foam Cells;Gene Expression;Glucose;Glycolysis;Goals;Homeostasis;Human;Immune;Immune response;improved;In Vitro;in vivo Model;Inflammation;Inflammatory;Ingestion;inhibitor;Investigation;Ischemic Stroke;knock-down;lipid metabolism;lipidomics;Lipids;Lipoproteins;Liver X Receptor;Macrophage;Mass Spectrum Analysis;Measures;Metabolic;Metabolic Pathway;Microglia;migration;Mitochondria;mitochondrial autophagy;mitochondrial metabolism;Molecular;Molecular Mechanisms of Action;monocyte;Mus;Myocardial Infarction;Myocardial Ischemia;Necrosis;new therapeutic target;Normal tissue morphology;novel;Nuclear;Outcome;oxidized low density lipoprotein;paracrine;pathogen;Pathology;Pathway interactions;Peptide Hydrolases;Perception;Phagocytes;Phagocytosis;Phenotype;Play;prevent;Production;programs;Proteins;Public Health;Reactive Oxygen Species;Regulation;Reporting;Respiration;response;Role;Signal Transduction;Sterols;Superoxides;Testing;therapeutic development;therapeutic target;Time;Tissues;uptake;Work

PROJECT_TITLE: Complement Protein C1q Regulation of Macrophage Metabolic Pathways


NIH_SPENDING_CATS: Cancer;Clinical Research;Contraception/Reproduction;Infertility;Pediatric;Radiation Oncology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation;Urologic Diseases

ORG_CITY: Pittsburgh

ORG_NAME: MAGEE-WOMEN'S RES INST AND FOUNDATION

PHR: Project Narrative In a preclinical Rhesus macaque model of cancer survivorship, this application will to develop next generation therapies to preserve and restore the fertility of males who are at risk of infertility due to their medical treatments. We will test a combination of pharmacological- and tissue-based therapies to preserve and/or restore fertility in a monkey model and with testicular tissues from human patients. Progress in the proposed application will expand the menu of reproductive options available to patients who have frozen their testicular tissues prior to gonadotoxic therapies.

PI_NAMEs: MEISTRICH, MARVIN L.;ORWIG, KYLE EDWIN (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Adult;Animals;Autologous Transplantation;Back;Bilateral;Biological;Biopsy;boys;cancer cell;Cancer Model;Cancer Patient;Cancer Survivor;Cancer Survivorship;cancer therapy;Castration;chemotherapy;Chemotherapy and/or radiation;clinically relevant;Cryopreservation;CSF3 gene;Cytotoxic Chemotherapy;Data;design;Devices;Distress;Environment;experimental study;Exposure to;Failure;Fertility;fertility preservation;Fertilization;Fibroblast Growth Factor;Fibroblast Growth Factor Receptors;Freezing;Future;Gametogenesis;Goals;Granulocyte Colony-Stimulating Factor;Growth;Human;human tissue;iatrogenic injury;immunodeficiency;Implant;improved;In Vitro;Individual;Infertility;Intervention;irradiation;leukemia;Macaca;Macaca mulatta;male;male fertility;Male Infertility;Malignant neoplasm of testis;mature animal;Medical;men;Methods;Microfluidic Microchips;Modeling;Monkeys;Morphology;Mus;Mutation;Natural regeneration;neoplastic cell;next generation;Non-Malignant;novel;offspring;Oocytes;Organ Culture Techniques;Patients;Permeability;pharmacologic;pre-clinical;Predisposition;prepuberty;preservation;Production;programs;Puberty;Radiation induced damage;Radiation therapy;Recovery;reproductive;Research;Rhesus;Risk;Signal Transduction;Skin;Sperm Banks;sperm cell;sperm function;Spermatogenesis;stem cell proliferation;Stem cell transplant;stem cells;Techniques;Technology;Testicular Tissue;Testing;Testis;Time;Tissues;tool;Translating;translational approach;Translations;Virus;Work

PROJECT_TITLE: Next Generation Therapies for Fertility Preservation in Male Cancer Patients

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetic Testing;Genetics;Human Genome;Lung;Lung Cancer;Prevention;Rare Diseases;Tobacco;Tobacco Smoke and Health

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Project Narrative The proposed study will provide an evidence for the contribution of inherited mutations in DNA damage repair (DDR) genes in lung cancer susceptibility and etiology. It has immediate translational and preventive implications as lung cancer patients with DDR abnormalities would benefit from targeted therapies, such as PARP inhibitors and the genetic testing offered to undiagnosed relatives (cascade testing) would identify high-risk individuals for earlier or more frequent low doze CT screening for early detection.

PI_NAMEs: MUKHERJEE, SEMANTI  (contact)

PROGRAM_OFFICER_NAME: CARRICK, DANIELLE M

PROJECT_TERMS: Address;Affect;Age;Algorithms;American;Architecture;Biological;Biological Assay;brca gene;BRCA2 gene;cancer diagnosis;Cancer Etiology;Cancer Patient;cancer predisposition;cancer risk;cancer type;Cancer-Predisposing Gene;cascade genetic testing;case control;Cell Line;Cessation of life;Characteristics;CHEK2 gene;chemotherapy;cigarette smoking;Clinical;clinical sequencing;Clinical Trials;clinically actionable;clinically significant;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collaborations;computed tomography screening;Data;Defect;Diagnosis;Disease;Disease-Free Survival;DNA Repair;driver mutation;Early Diagnosis;early onset;England;Environmental Risk Factor;ERCC2 gene;Etiology;Excision;exome sequencing;Family;Family history of;Family member;gene repair;gene-editing approach;Genes;Genetic;genetic linkage analysis;Genetic Risk;genetic testing;genome sequencing;genome wide association study;Genomics;genotoxicity;Genotype;Germ Lines;Germ-Line Mutation;Goals;Guidelines;high risk;high risk population;High-Risk Cancer;Histologic;improved;individual variation;Inheritance Patterns;Inherited;inhibitor;insight;Institution;International;Laboratories;Loss of Heterozygosity;Lung;Lung Adenocarcinoma;lung cancer screening;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Medical Genetics;medical schools;Memorial Sloan-Kettering Cancer Center;Modeling;Modification;Mutation;mutational status;never smoker;Newly Diagnosed;next generation sequencing;Normal tissue morphology;novel;Odds Ratio;Operative Surgical Procedures;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;patient derived xenograft model;Patients;Penetrance;Phenotype;Poly(ADP-ribose) Polymerase Inhibitor;Population Database;Predisposition;Preventive;Primary Neoplasm;Prognostic Marker;Recording of previous events;Recurrence;repaired;Research;Risk;Risk Estimate;Risk Factors;Role;Sampling;segregation;Smoker;Smoking;Smoking Behavior;Smoking Status;Somatic Mutation;Squamous Cell Lung Carcinoma;Survival Rate;Syndrome;targeted treatment;Technology;Testing;The Cancer Genome Atlas;therapeutic evaluation;Tissue Sample;Tobacco;Tobacco smoking behavior;TP53 gene;treatment response;tumor;Variant;variant of unknown significance;whole genome;Work

PROJECT_TITLE: Discovery and characterization of clinically actionable germline mutations in DNA damage repair (DDR) pathway genes in lung cancer

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative This proposed research is relevant to public health because it focuses on understanding a new mechanism of immune evasion by glioblastoma (GBM), the most common and incurable brain tumor in adults; and developing a novel therapeutic strategy based on this scientific rationale. Once such strategies have been tested, there is the potential for a significant advance in cancer therapy for patients with this devastating brain tumor. Thus, the proposed research is relevant to the part of the NIH’s mission that pertains to reducing illness and disability.

PI_NAMEs: HU, BAOLI  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Adoptive Transfer;Adult;Animals;Binding;Binding Proteins;Biological Response Modifiers;Bone Marrow;Brain;Brain Diseases;Brain Neoplasms;cancer therapy;Cells;CHI3L1 gene;Clinical Trials;Combined Modality Therapy;Complex;cytokine;Data;data mining;design;Development;disability;effective therapy;Equilibrium;Family;Functional disorder;gain of function;Galactose Binding Lectin;Galectin 3;Gene Expression;Glioblastoma;Glioma;Glycoproteins;Goals;Growth;Heterogeneity;immune checkpoint blockade;Immune checkpoint inhibitor;Immune Evasion;Immunologic Stimulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;innovation;insight;Knowledge;loss of function;Lymphocyte Activation;Lymphocytic Infiltrate;Macrophage;Malignant Neoplasms;Mediating;member;Microglia;migration;Mission;Molecular;mouse model;neoplastic cell;novel;novel therapeutic intervention;overexpression;Pathway interactions;Patients;Peptides;peptidomimetics;pharmacologic;Phenotype;pre-clinical;pre-clinical assessment;preclinical efficacy;Process;Production;programs;protein complex;Proteins;Public Health;Recombinant Proteins;recruit;Research;Resistance;response;Signal Transduction;Survival Rate;T cell infiltration;T-Lymphocyte;Testing;Therapeutic;Therapeutic Trials;therapeutically effective;transcriptome sequencing;Translational Research;Treatment Efficacy;treatment strategy;tumor;Tumor Immunity;tumor microenvironment;tumor progression;Tumor-associated macrophages;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;United States National Institutes of Health

PROJECT_TITLE: Chitinase-3-like-1 mediated immunosuppression in Glioblastoma

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Neurosciences;Nutrition;Obesity

ORG_CITY: POMONA

ORG_NAME: CALIFORNIA STATE POLY U POMONA

PHR: Project Narrative Disorders associated with under- and over-eating cause many health problems and are costing the United States billions of dollars in medical care. Although hunger-sensing neurons in a part of the brain called the hypothalamus have been identified, we do not know which neurons in the brain regulate the timing of feeding and, in turn, influence activity levels. This proposal seeks to identify the dopamine neurons and their targets that link feeding and timing of circadian rhythms.

PI_NAMEs: STEELE, ANDREW DAVID (contact)

PROGRAM_OFFICER_NAME: RICHARDS, CRYSTAL LYNETTE

PROJECT_TERMS: Activity Cycles;Adaptive Behaviors;Address;Anatomy;Animals;Back;Behavior;behavior observation;Behavioral;Biological Process;Brain;calbindin;Caring;circadian;Circadian Rhythms;conditional knockout;Corpus striatum structure;cost;Data;Dependovirus;designer receptors exclusively activated by designer drugs;Disease;Dopamine;dopamine transporter;dopaminergic neuron;Dorsal;Eating;Enzymes;Exhibits;experimental study;feeding;feeding schedule;Food;Fright;Genetic;Genetic Identity;genetic manipulation;grasp;Health;Hunger;Hyperphagia;Hypothalamic structure;Injections;Knockout Mice;Light;light entrainment;Link;LoxP-flanked allele;Maps;Measures;Medial;Mediating;Medical;Modernization;Mus;Nature;nerve supply;neural circuit;Neurobiology;Neurons;neurotransmission;Physiological;Play;Population;Production;Rattus;Recording of previous events;Regulation;Research;response;restoration;retrograde transport;Role;Signal Transduction;Site;Societies;Stimulus;Substantia nigra structure;suprachiasmatic nucleus;System;Techniques;Temperature;Testing;Time;tool;translational impact;Translational Research;Tyrosine 3-Monooxygenase;United States;Viral;Vision

PROJECT_TITLE: Deciphering dopaminergic circuits required for food anticipatory activity in mice


ORG_CITY: White River Junction

ORG_NAME: WHITE RIVER JUNCTION VA MEDICAL CENTER

ORG_STATE: VT

PHR: Posttraumatic Stress Disorder (PTSD) is a common and serious condition affecting many Veterans. There are effective treatments for PTSD, but additional treatments are needed in order to better serve Veterans suffering from PTSD. Transcranial magnetic stimulation is one such promising treatment. It involves use of powerful magnet to stimulate the specific brain regions in Veterans with PTSD. Transcranial magnetic stimulation has been shown effective in treating depression, but currently it is unclear if it is an effective treatment for PTSD. We propose to conduct a randomized clinical trial in 91 Veterans with PTSD comparing the effectiveness of transcranial magnetic stimulation treatment and sham transcranial magnetic stimulation in treating PTSD.

PI_NAMEs: WATTS, BRADLEY V. (contact)

PROJECT_TERMS: Affect;Aftercare;Brain region;Characteristics;Chronic;comparative efficacy;compare effectiveness;depressed patient;depressive symptoms;Development;Disabling condition;DSM-V;effective therapy;evidence base;follow-up;functional disability;functional improvement;functional outcomes;Goals;Health;improved;Measures;Medical center;Mental Depression;military veteran;novel;Outcome;Participant;Patients;Pharmaceutical Preparations;Placebos;Post-Traumatic Stress Disorders;Prefrontal Cortex;primary outcome;Psychotherapy;Randomized;randomized, clinical trials;Recovery;Recovery of Function;reduce symptoms;rehabilitation research;repetitive transcranial magnetic stimulation;Research;research and development;Role;secondary outcome;Severities;side effect;symptomatic improvement;Symptoms;Transcranial magnetic stimulation;United States Food and Drug Administration;Veterans

PROJECT_TITLE: Transcranial Magnetic Stimulation to Improve Functioning in Veterans with PTSD

STUDY_SECTION_NAME: Behavioral Health & Social Reintegration[RRD4]


ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative More than one-quarter of translated proteins enter the secretory pathway. Our research is designed to elucidate sorting mechanisms that guide a broad range of secretory proteins through the early stages of this pathway. Defects in biogenesis of secretory proteins have wide-ranging effects on human health and disease including atherosclerosis, blood clotting disorders, kidney disease and cystic fibrosis.

PI_NAMEs: BARLOWE, CHARLES K (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Affinity;anterograde transport;Atherosclerosis;Back;Binding;Biochemical;Biogenesis;Biological Assay;Biophysics;Blood coagulation;Blood Coagulation Disorders;cell growth;Cell Physiology;Cells;Client;Coat Protein Complex I;Coated vesicle;Coatomer-Coated Vesicles;Complex;COPII-Coated Vesicles;Coupled;Cysteine;Cystic Fibrosis;Defect;design;Disease;Disulfide Linkage;Disulfides;Endoplasmic Reticulum;Endoplasmic Reticulum Degradation Pathway;Ensure;Environment;Equilibrium;experimental study;Family member;FPR2 gene;Funding;Futile Cycling;Genetic;Goals;Golgi Apparatus;Health;Human;human disease;Hydrophobicity;in vivo;insight;Isomerism;Kidney Diseases;Knowledge;Maps;Mass Spectrum Analysis;Measures;Mediating;Membrane;Methods;misfolded protein;Modeling;Molecular;molecular modeling;Monitor;novel;Organelles;Oxidation-Reduction;Pathway interactions;Process;programs;protein degradation;Protein Disulfide Isomerase;protein folding;protein function;Protein Sortings;protein transport;Proteins;Quality Control;receptor;receptor function;reconstitution;Research;Research Proposals;Retrieval;retrograde transport;Role;secretory protein;Sorting;Testing;Translating;TXN gene;uptake;Vesicle

PROJECT_TITLE: Mechanisms in COPII-Dependent Transport

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Disability Research;Hearing Loss;Neurosciences;Prevention;Rehabilitation

ORG_CITY: SAINT LOUIS

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Despite the overwhelming success of cochlear implants, there remains wide variability in performance related to both patient and treatment factors. This project will use electrocochleography to assess cochlear health together with tests of cognitive function to develop prediction tools for speech perception abilities in quiet and background noise among cochlear implant candidates. Predicting performance has direct relevance to patient counseling and shared decision making (between clinician and patient), design and recommendations for auditory rehabilitation after cochlear implantation, consideration for device mapping and troubleshooting, and patient stratification in future clinical trials.

PI_NAMEs: BUCHMAN, CRAIG A. (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Acoustics;Address;Adult;Area;Audiology;Auditory;auditory rehabilitation;Auditory system;Biography;Biological Markers;Clinic;Clinical;Clinical Trials;Cochlea;Cochlear implant procedure;Cochlear Implants;Cognitive;cognitive ability;cognitive function;cognitive testing;Communication;cost;Counseling;design;Development;Devices;Ear;Educational Status;Elderly;Electrocochleographies;Electrodes;Electrophysiology (science);Employment Opportunities;Etiology;Future;Geography;Health;Hearing;Hearing Aids;hearing impairment;Image;Impaired cognition;Implant;improved;indexing;Individual;instrument;Location;Maps;Measures;Mental Depression;Methods;Modeling;National Institute on Deafness and Other Communication Disorders;neural;Noise;older patient;Operating Rooms;Operative Surgical Procedures;patient stratification;Patients;Performance;Population;Postoperative Period;predictive modeling;predictive tools;processing speed;Quality of life;Recommendation;response;round window;Science;screening;Severities;shared decision making;Short-Term Memory;Site;Societies;Speech;speech in noise;Speech Perception;success;Testing;Treatment Factor;Universities;Validation;Vocabulary;Washington;Work;X-Ray Computed Tomography

PROJECT_TITLE: Predicting Performance in Adult Cochlear Implantation

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE Latino youth face longstanding disparities in health care access and utilization, especially the 9 million youth in immigrant families who represent half of Latino youth in the US. This study will take advantage of a unique opportunity to examine the multiple levels of influence that contribute to these disparities through a follow-up study of 1000 Latino youth and their families in the California Health Interview Survey (CHIS). California has the largest Latino and immigrant populations in the country, and CHIS captures the many unique dimensions of family citizenship and documentation statuses, making them an ideal state and survey in which to study health care disparities for Latino youth and families.

PI_NAMEs: ORTEGA, ALEXANDER N (contact);PONCE, NINEZ ALAFRIZ

PROGRAM_OFFICER_NAME: SOLIS SANABRIA, CAROLINA VANESSA

PROJECT_TERMS: access disparities;Affect;Affordable Care Act;Age;barrier to care;Behavior;Birth;California;care systems;Caring;Communities;Country;County;Data;Data Files;Dimensions;Disparity;Documentation;Eligibility Determination;Exclusion;Face;Family;follow-up;Follow-Up Studies;Funding;Health;health care availability;health care disparity;Health care facility;health care service utilization;health communication;health determinants;Health Disparities Research;health disparity;Health Insurance;Health Personnel;health service use;Health Services Accessibility;Health Surveys;Health system;Healthcare;Home;Immigrant;Immigrant family;Immigration;Improve Access;Income;Individual;Institution;Insurance;Intervention;Interview;Joints;Latino;Latino Population;Laws;Linguistics;long-standing disparities;Measures;Medicaid;minority health;minority health disparity;Modeling;National Institute on Minority Health and Health Disparities;Parents;Participant;Patients;Pattern;Perception;Policies;Population;Population Analysis;population based;population health;Preventive healthcare;Process;Provider;Research;Resources;Risk;safety net;Sampling;Secure;Services;Siblings;Site;Societal Factors;Source;Surveys;Trust;Variant;welfare;Youth

PROJECT_TITLE: Understanding the Multiple-levels of Influence on Access to Care for Latino Youth

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


NIH_SPENDING_CATS: Infectious Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Narrative: Using in vivo models the studies will define the molecular and cellular mechanisms through which subsets bone marrow vessels control infection/inflammation-induced myelopoiesis. Identification of the mechanisms used by local vessels to provide spatiotemporal control of distinct HSPC in response to stress is expected to result in the identification of novel targets and strategies for therapeutic intervention

PI_NAMEs: LUCAS, DANIEL  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Architecture;Blood Vessels;Bone Marrow;Candida albicans;conditional knockout;CSF1 gene;CSF3 gene;cytokine;Data;Dendritic Cells;Emergency Situation;Endothelial Cells;Erythropoiesis;experimental study;Failure;granulocyte;Hematopoiesis;Hematopoietic stem cells;IL1R1 gene;Image;In Situ;in vivo Model;Infection;Infection Control;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;Interleukin-1;Knockout Mice;Listeria monocytogenes;loss of function;Maps;Marrow;Molecular;monocyte;MPP2 gene;MPP3 gene;Multipotent Stem Cells;Myelogenous;Myelopoiesis;neutrophil;new therapeutic target;novel;Output;Production;progenitor;response;Role;selective expression;Signal Transduction;spatiotemporal;stem cell aging;stem cell function;stem cells;Stress;Study models;technique development;Testing;Therapeutic Intervention

PROJECT_TITLE: Role of the local vascular microenvironment in the bone marrow response to inflammation

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Nutrition;Obesity;Prevention;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: NATIONAL OPINION RESEARCH CENTER

ORG_STATE: IL

PHR: About 35% of U.S. adults report eating more or eating high-calorie/fat/sugar foods in response to stress or other negative emotions—a behavior known as comfort eating that increases risk for weight gain and the development of type 2 diabetes. Prior comfort eating interventions have used similar techniques and a one- size-fits all approach, achieving mixed results; however, new information about when and why comfort eating first develops, the characteristics of people who do and do not have confidence in their ability to quit comfort eating, and which groups of people are most at risk for poor health related to comfort eating will enable a new generation of targeted, tailored, and innovative intervention and prevention approaches. The present project will draw upon a rich data from a large, diverse, national sample of 2,022 U.S. adults age 18 and older— including current comfort eaters, former comfort eaters, and never comfort eaters—to fill these crucial gaps in knowledge, paving the way forward for future research to more effectively curb comfort eating and its adverse health impacts.

PI_NAMEs: FINCH, LAURA ELIZABETH (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Address;Adolescence;Adopted;Adult;Age;Behavior;Behavioral;Belief;biological adaptation to stress;Body mass index;Calories;Censuses;Characteristics;Childhood;college;coping;cost;Data;demographics;depressive symptoms;Development;Diabetes Mellitus;Eating;Eating Behavior;Emotions;Environment;Etiology;Event;Exhibits;experience;experimental study;Family member;Fatty acid glycerol esters;Finches;Food;food insecurity;food preparation;Frequencies;Future;Generations;Goals;Health;Health Food;Home environment;Human Development;human old age (65+);Individual;innovation;insight;Intervention;intervention effect;Investigation;Knowledge;Life;Life Cycle Stages;life span;Link;Literature;low socioeconomic status;Mediating;Methods;middle age;Midlife women;National Institute of Diabetes and Digestive and Kidney Diseases;neglect;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Overweight;Persons;poor health outcome;Prediabetes syndrome;Preparation;prevent;Prevention;Prevention approach;Process;Psychophysiology;Psychosocial Factor;repaired;Reporting;Research;Respondent;response;Risk;Sampling;saturated fat;Self Efficacy;Social support;Sodium Chloride;Stress;stress symptom;Subgroup;sugar;sweet taste perception;Techniques;Testing;Time;Weight Gain;Woman

PROJECT_TITLE: Comfort eating in the Eating in America Study: New insights to inform prevention and intervention efforts across the lifespan

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Lung;Patient Safety;Rare Diseases

PHR: PROJECT NARRATIVE Acute respiratory failure requiring mechanical ventilation is a common cause of morbidity and mortality during critical illness. Spontaneous drive to breathe varies in unpredictable ways during acute respiratory failure and could be protective or harmful depending on clinical context. This research will deepen understanding of mechanisms underlying respiratory drive heterogeneity and its relationship with clinical outcomes in mechanically ventilated patients with acute respiratory failure.

PI_NAMEs: BEITLER, JEREMY R. (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Acute respiratory failure;adjudication;Advanced Development;Angiopoietin-2;Anxiety;Attenuated;Automobile Driving;Biological Markers;Blood - brain barrier anatomy;Breathing;Carbon Dioxide;Carotid Body;Chemoreceptors;circulating biomarkers;Clinical;Clinical Data;clinical diagnosis;Clinical Trials;clinically relevant;cohort;Critical Illness;cytokine;Cytokine Receptors;Data;Development;Disuse Atrophy;electrical impedance tomography;Electronic Health Record;Esophagus;Evaluation;Exhalation;Exhibits;experience;Future;Heterogeneity;high risk;Hospitals;IL8 gene;Individual;Inflammation;Inflammatory;inflammatory marker;Injury;Injury to Diaphragm;Insufflation;Intensive Care Units;Investigation;Knowledge;Light;Link;Lung;lung injury;Manometry;Measures;Mechanical ventilation;Mechanics;Mechanoreceptors;Morbidity - disease rate;mortality;mortality risk;multiorgan injury;Muscle;Outcome;Oxygen;Pain;Pathway interactions;Patients;Pattern;Physicians;Pre-Clinical Model;premature;pressure;Prevention;prospective;Receptor Signaling;Refractory;Reporting;Research;Residual state;Resolution;respiratory;Respiratory Diaphragm;Respiratory Mechanics;Respiratory Muscles;Risk;Sampling;Sedation procedure;Serum;Stress;Structure;Syndrome;systemic inflammatory response;Testing;Tidal Volume;Time;Titrations;ultrasound;ventilation;Ventilator;Ventilator-induced lung injury;Work

PROJECT_TITLE: Respiratory Drive in Acute Respiratory Failure

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Pediatric;Pediatric - AIDS;Rare Diseases;Tuberculosis

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) is a leading cause of morbidity and mortality in young children <5 yr. old, especially children with underlying HIV-infection (HIV+). The vulnerability of young HIV- exposed and unexposed children to develop TB following primary infection is not understood, and current diagnostic tools perform poorly. Our proposal will advance pediatric global health by: 1) identification of immunologic signatures reflecting successful containment of primary Mtb infection that can serve as correlates of protective immunity for novel vaccine trials; 2) development of novel blood-based assays that discriminate between young children with TB and those who have successfully contained their infection.

PI_NAMEs: LANCIONI, CHRISTINA LOUISE (contact);MUPERE, EZEKIEL ;STEIN, CATHERINE MARIE

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: adaptive immune response;Adult;Antibodies;B-Lymphocytes;biobank;Biological Assay;biosignature;Blood;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Child;Childhood;Clinical;Clinical Management;Containment;cytokine;Death Rate;design;Development;Diagnostic;Diagnostic tests;diagnostic tool;Disease;Epidemiology;Epitopes;Exhibits;experience;Flow Cytometry;global health;Health;high risk;high risk population;HIV;HIV Infections;Home;Household;Immune;Immune response;Immunity;Immunologics;improved;Individual;Infant;Infection;Knowledge;latent infection;Life;Monitor;Morbidity - disease rate;mortality;Mothers;Mycobacterium tuberculosis;novel;novel vaccines;Phenotype;Pneumonia;pre-clinical;Primary Infection;progression risk;Prospective cohort;Pulmonary Tuberculosis;reactivation from latency;response;Sampling;T cell response;Tuberculosis;Uganda;vaccine trial;Vaccines;Work

PROJECT_TITLE: Defining adaptive immune responses to Mtb-infection and TB disease among young children with and without HIV-exposure

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: FARGO

ORG_NAME: NORTH DAKOTA STATE UNIVERSITY

ORG_STATE: ND

PHR: Project Narrative This study will describe in-school menstruation-related experiences of American Indian girls in rural, reservation communities as well as the experiences, perceptions, and comfort level of middle and high school educators in responding to the menstrual experiences of their students. The results of this research will provide insights into the school-based menstruation experiences of American Indian female adolescents and the perceptions of educators in reservation-based middle and high schools about the impacts of menstruation on learning and educational outcomes in the school setting. The findings will lay the groundwork for tailoring interventions addressing educational disparities for AI adolescent girls.

PI_NAMEs: HUSETH-ZOSEL, ANDREA LYNN (contact);SECOR, MOLLY ANN

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Address;Adolescent;adolescent health outcomes;Adult;Affect;Age;American Indian Women;American Indians;Attitude;Behavior;Characteristics;Communities;culturally appropriate intervention;Custom;Data;design;Disparity;Education;Educational process of instructing;Educational Status;Environment;experience;Female;Female Adolescents;Focus Groups;Fostering;Frequencies;Future;Gender;geographic barrier;girls;Goals;Graduation Rates;Great Plains;Health;health disparity;high school;High School Faculty;Hygiene;improved;Indian reservation;innovation;insight;Intervention;junior high school;Knowledge;Learning;learning outcome;Link;low and middle-income countries;Low income;Menstruation;Mental Health;Methods;Middle School Faculty;North Dakota;Northern Plains;Outcome;peer;Perception;Personal Satisfaction;Physical activity;physical conditioning;Policies;poor health outcome;Population;Poverty;Pregnancy in Adolescence;Preparation;Puberty;Reporting;Research;reservation-based;Reservations;Resource-limited setting;Risk;Risk Factors;Rural;rural area;Schools;sexual and reproductive health;sexual debut;sexual risk behavior;Sexual Transmission;social exclusion;social stigma;South Dakota;Students;success;teacher;Time;Tribal School;Unemployment;United States;Woman;Work

PROJECT_TITLE: Determining the impact of menstruation experiences on the health and well-being of American Indian adolescent females

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Our long-term goal is to develop a new therapy for glaucoma, a prevalent eye disease characterized by increased intraocular pressure, neurodegeneration of the retina, and vision loss. We are focusing on myocilin, an extracellular matrix protein involved in regulating eye pressure; mutations in myocilin lead to an early-onset, inherited form of glaucoma. We are studying disease-causing mutants to understand the molecular mechanisms of pathogenesis, which, in turn, is guiding our efforts develop a new therapeutic that treats the underlying cause of the disease.

PI_NAMEs: LIEBERMAN, RAQUEL L (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: 3-Dimensional;Academia;Acceleration;Affect;Age of Onset;Alleles;Alzheimer's Disease;Amyloid;Amyloid Fibrils;amyloid formation;Amyloidosis;Amyotrophic Lateral Sclerosis;Anatomy;Anterior eyeball segment structure;Aqueous Humor;Benign;biophysical properties;blind;Blindness;Cell Death;Cells;Chemicals;Clinic;Comprehension;cytotoxic;cytotoxicity;Data;Databases;Defect;Deuterium;Development;Diagnosis;Disease;Drainage procedure;early onset;Endoplasmic Reticulum;Exhibits;experimental study;Extracellular Matrix;Extracellular Matrix Proteins;Eye;Eye diseases;Fingerprint;Foundations;Functional disorder;Funding;gain of function;genome wide association study;Glaucoma;Glean;Goals;Grant;Growth;High temperature of physical object;Homeostasis;Horns;Hydrogen;Industry;infancy;Inherited;insight;Knowledge;Lead;Length;Liquid substance;Mass Spectrum Analysis;Measures;Medical;Medicine;Methods;Missense Mutation;Modality;Molecular;Molecular Chaperones;Molecular Conformation;Molecular Structure;multidisciplinary;Mutagenesis;mutant;Mutation;myocilin;Nerve Degeneration;non-Native;novel;novel therapeutics;Nuclear Magnetic Resonance;olfactomedin;Open-Angle Glaucoma;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;patient population;Patients;Peptides;Physiologic Intraocular Pressure;Physiology;Play;precision medicine;pressure;Process;Protein Biochemistry;protein folding;protein misfolding;Proteins;proteostasis;rare variant;Relaxation;Research Personnel;Retina;Risk Factors;Role;Sampling;solid state nuclear magnetic resonance;structural biology;Structure;superoxide dismutase 1;Susceptibility Gene;symptom treatment;Testing;Therapeutic;Time;timeline;Tissues;Toxic effect;Trabecular meshwork structure;Variant;Vertebral column

PROJECT_TITLE: Characterization of purified myocilin: glaucoma as a protein misfolding disease

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Machine Learning and Artificial Intelligence;Nanotechnology

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE By leveraging optical spectroscopy, nanofabrication, and machine learning, this proposal advocates the development of three innovative platforms for ultrasensitive molecular sensing and nano-imaging in diverse biological systems. We propose to develop highly sensitive and spectrally enriched Raman sensing approach for multiplexed molecular detection by realizing surface-enhanced Raman spectroscopy in the strong coupling regime. We also seek to employ self-assembly principles to: engineer a highly sensitive nanoscale magnetometer for intracellular quantum sensing; and design a new class of Raman-active peptide-based nanoprobes for targeted cellular imaging.

PI_NAMEs: BARMAN, ISHAN  (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Address;Advocate;Affect;Biological;biological systems;biomaterial compatibility;Biomimetics;Biosensing Techniques;Cells;cellular imaging;Cellular Structures;cellular targeting;Coupling;cryptochrome;design;Detection;Development;DNA;Engineering;Enzymes;functional group;imaging probe;improved;In Situ;innovation;Ions;Machine Learning;magnetic field;Magnetism;Methods;Molecular;Molecular Analysis;molecular imaging;Monitor;nano;nanodiamond;nanofabrication;nanoimaging;nanoprobe;nanoscale;next generation;Nitrogen;novel;Optics;Peptides;Physical condensation;plasmonics;Process;programs;quantum;quantum sensing;Raman Spectrum Analysis;rational design;Reaction;Research;Resolution;Role;Scheme;self assembly;single cell analysis;spatiotemporal;Specificity;Spectrum Analysis;Structure;Surface;synthetic peptide;targeted imaging;Tissues;vibration;Visualization software

PROJECT_TITLE: Next-generation optical nanoprobes: From quantum biosensing to cellular monitoring

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cocaine;Drug Abuse (NIDA only);Genetics;Human Genome;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: CLEMSON

ORG_DEPT: GENETICS

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: HEALTH RELEVANCE Illegal use of psychostimulants such as cocaine presents a worldwide health problem with huge socioeconomic costs to societies; however, little is known about genetic risk factors for substance abuse. We will use the powerful Drosophila melanogaster genetic model to precisely map variants that affect cocaine preference and consumption, perform a systems genetic analysis to infer causal regulatory networks associated with these traits, and use germline gene editing to prove causality of the genetic associations with cocaine preference and gene regulatory networks. Since approximately 67% of Drosophila genes have a human counterpart, both general principles derived from these studies and individual network elements will be relevant to human substance abuse phenotypes.

PI_NAMEs: ANHOLT, ROBERT R. H;MACKAY, TRUDY F. (contact)

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: Affect;Alcohols;Alleles;Atlases;Behavior;Biological Assay;Biological Process;Brain;Candidate Disease Gene;causal variant;Cells;Cocaine;cocaine exposure;cocaine seeking;cocaine use;comorbidity;Consumption;cost;Crime;CRISPR/Cas technology;Data;Drosophila genus;Drosophila melanogaster;Drug abuse;Drug Addiction;Drug Costs;Drug Exposure;economic cost;Elements;Etiology;Exposure to;fly;Gene Expression;Gene Expression Regulation;gene regulatory network;Generations;Genes;Genetic;genetic analysis;genetic association;Genetic Models;genetic resource;genetic risk factor;Genetic Transcription;genetic variant;Genetic Variation;Genome;genome wide association study;Genomic Segment;Germ Lines;Health;Healthcare;Human;illicit drug use;Imprisonment;in vivo;Inbreeding;Individual;insight;Maps;model organism;Molecular;National Institute of Drug Abuse;network architecture;neuropsychiatric disorder;Nicotine;Orthologous Gene;Persons;Pharmaceutical Preparations;Phenotype;Population;population based;Predisposition;preference;productivity loss;psychostimulant;Public Health;Quantitative Trait Loci;rare variant;Resolution;Sample Size;Societies;socioeconomics;stimulant use;Substance abuse problem;System;Tobacco use;trait;transcriptome sequencing;translational potential;translational study;Untranslated RNA;Variant

PROJECT_TITLE: Genetics of Cocaine Sensitivity in Drosophila


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Data Science;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Relevance to Public Health Our project will provide fundamentally novel solutions to map the superficial white matter connectome by developing surface-based tools for fiber tracking, atlas construction, personalized analysis, and personalized tools for data harmonization. These novel tools will allow brain imaging researchers to augment their current connectome models with U-fibers in superficial white matter and more completely map human brain connectomes in various brain disorders.

PI_NAMEs: SHI, YONGGANG  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Accounting;Age;Aging;aging brain;Algorithms;Anatomy;Area;Atlases;Attention;Autopsy;Brain;Brain Diseases;Brain imaging;Collaborations;Communities;computerized tools;connectome;Data;data harmonization;Data Pooling;Data Set;data tools;Dedications;deep learning algorithm;Detection;Development;Diffusion Magnetic Resonance Imaging;Epilepsy;experience;experimental study;Fiber;Funding;Geometry;Goals;Health;health disparity;Human;Image;image registration;Imaging Techniques;Implanted Electrodes;improved;in vivo;Informatics;Injections;large scale data;life span;longitudinal dataset;Magnetic Resonance Imaging;Manuals;Maps;Masks;Methods;Modeling;multimodality;Mus;National Institute of Biomedical Imaging and Bioengineering;neural;neuroimaging;Normalcy;novel;Operative Surgical Procedures;Pathway interactions;Patients;Play;Public Health;reconstruction;recruit;Research;Research Personnel;Resolution;Role;Series;shape analysis;Site;Software Tools;Surface;Techniques;Time;tool;Tracer;tractography;Validation;Variant;vector;white matter;Work

PROJECT_TITLE: Surface-Based Fiber Tracking and Modeling Techniques for Mapping the Superficial White Matter Connectome with Diffusion MRI

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative  Alzheimer’s disease and related dementias are common, devastating and incurable disorders. The protein alpha-  synuclein  commonly  aggregates  in  these  diseases.  Here,  in  patient  stem- cell  models  and  brain  tissue,  we   thoroughly  investigate  the  mechanisms  through  which  this  protein  aggregates  with  a  view  to  developing  new  understanding and therapies.

PI_NAMEs: KHURANA, VIKRAM  (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Affect;Affinity;alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Amyloid beta-Protein;Amyloid fibers;amyloid fibril formation;amyloid formation;Autopsy;Biochemical;Biological;Brain;brain cell;brain tissue;Cell Line;Cell model;cell type;Cells;Ceramides;cerebral atrophy;Characteristics;Circular Dichroism Spectroscopy;Coculture Techniques;conformer;Data;Dementia with Lewy Bodies;Development;Diffuse;Disease;Disparate;dopaminergic neuron;Electron Microscopy;Equation;experimental study;Fluorescence;Future;genetic manipulation;Genetic study;glucosylceramidase;Glucosylceramides;Goals;Grant;Heterozygote;Homeostasis;Human;Human Genetics;human induced pluripotent stem cells;human stem cells;Image;Immunofluorescence Microscopy;Impaired cognition;In Vitro;in vitro Assay;in vivo;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;interest;Intervention;kindred;Knock-in;Knock-out;Lead;Lesion;Lewy Bodies;Lewy body pathology;Lipids;Membrane;Membrane Lipids;Membrane Proteins;mimetics;misfolded protein;Modeling;Morphology;mouse model;Multiple System Atrophy;Mutation;Nerve Degeneration;Neuroglia;Neurons;Nuclear Magnetic Resonance;Oligodendroglia;Parkinson's Dementia;Pathogenicity;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Pattern;Periodicity;pharmacologic;Phosphorylation;Physiological;pre-formed fibril;protein aggregation;Proteins;Proteolysis;Reporter;Saturated Fatty Acids;serial imaging;Series;Side;Spanish;Sphingolipids;Stearoyl-CoA Desaturase;stem cell model;Synaptic Vesicles;synucleinopathy;System;tau Proteins;tau-1;Testing;Toxic effect;trafficking;Transgenic Mice;Transgenic Organisms;validation studies;Vesicle;Work

PROJECT_TITLE: Elucidating the Biological Differences Between Distinct Fibrillar and Non-Fibrillar Alpha-Synuclein Inclusions in Human Stem-Cell Models

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;HIV/AIDS;Infectious Diseases;Networking and Information Technology R&D (NITRD);Prevention

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: This project proposes to conduct HIV incidence and drug resistance surveillance using microdop HIV sequencing that allows us to obtain HIV full-length envelope and pol gene sequences in high-precision and low cost. Our genomic surveillance, coupled with laboratory automation and cloud-based software-as-a-service, will promote the evidence base HIV prevention and intervention.

PI_NAMEs: LEE, HA YOUN  (contact)

PROGRAM_OFFICER_NAME: SHARMA, USHA K

PROJECT_TERMS: Accounting;Acquired Immunodeficiency Syndrome;Address;AIDS prevention;Algorithms;antiretroviral therapy;Automation;Bioinformatics;Biological Assay;Blood;case-based;Centers for Disease Control and Prevention (U.S.);Central Africa;cloud based;cloud platform;cohort;Communities;Complex;Consumption;cost;Coupled;Cross-Sectional Studies;Data;Data Analyses;data hub;design;Drops;Drug resistance;efficacy evaluation;Epidemic;Evaluation;evidence base;Genome;Genomics;Geographic Locations;Geography;Goals;Grant;High-Throughput Nucleotide Sequencing;HIV;HIV envelope protein;HIV Infections;HIV Seropositivity;HIV/AIDS;improved;Incidence;Individual;Infection;innovation;Intervention;Intervention Trial;invention;Investigation;Investments;Laboratories;Length;Link;low and middle-income countries;Minority;Monitor;Movement;Nigeria;open source;optimal treatments;Outcome;Output;Parents;Performance;Persons;Plasma;platform as a service;pol genes;Population;population survey;Prevalence;Prevention;Prevention trial;Procedures;programs;Publications;real time monitoring;Regimen;Reporting;Reproducibility;Research;Research Personnel;resistance mutation;Resistance profile;Resolution;Resource-limited setting;Robot;Robotics;Scheme;screening;software as a service;Specimen;Standardization;Surveys;System;Techniques;Time;tool;Variant;variant detection;Viral;web based software;Western Africa

PROJECT_TITLE: HIV Incidence and Drug Resistance Surveillance using Microdrop HIV Sequencing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-M(02)]