NIH_SPENDING_CATS: Clinical Research;Women's Health Research

ORG_CITY: RENO

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PI_NAMEs: BAKER, JONATHAN E. (contact)

PROGRAM_OFFICER_NAME: MATUKUMALLI, LAKSHMI KUMAR

PROJECT_TERMS: Address;Administrative Supplement;Advisory Committees;Annual Reports;Award;Biomedical Research;brain health;Cell Differentiation process;cell growth;Centers of Research Excellence;Characteristics;Clinical;Collaborations;Communication;Data;Data Science Core;Databases;Development;Educational process of instructing;Ensure;Evaluation;Faculty;flexibility;Funding;Goals;improved;Institution;Leadership;Link;meetings;member;Mentors;Mission;Network Infrastructure;Nevada;outreach;outreach program;Program Research Project Grants;programs;Progress Reports;Research;Research Activity;research faculty;Resource Sharing;Resources;Services;Sister;Students;success;Training;undergraduate research experience;undergraduate student;United States National Institutes of Health;web site;Women's Health;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: DC

ARRA_FUNDED: N

FUNDING_MECHANISM: INTERAGENCY AGREEMENTS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Disability Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Neurosciences;Nutrition;Rehabilitation;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PHR: Extensive research has been done on the measurement and causes of smell and taste disorders.  These disorders can be screened with a series of simple questions with inexpensive, brief odor identification tests and taste intensity tests coupled with further questions (problems past year, since age 25, phantom and altered sensations) that can screen for marked dysfunction. NIH-funded centers and research investigators provide direction for treatment of these disorders.  When properly diagnosed, some causes of impaired taste and smell are treatable. Treatments include: 1) over-the-counter or prescription medications, 2) quitting smoking if a smoker, 3) dental care, 4) changing medications or doses if current medications are causing impaired taste and smell, 5) chronic sinusitis, treated with antibiotics, and 6) surgery to remove nasal polyps. The causes of olfactory dysfunction that are most amenable to treatment include obstructing polyps or other masses (treated by excision) and inflammation (treated with steroids).  Nutritional counseling with enhancement of food flavor and appearance and maintenance of healthful eating and weight can improve quality of life in patients with irreversible dysfunction.  Health care providers should be prepared to offer education (particularly to older adults) about avoiding hazardous events if they have impaired senses of smell and taste.

PROJECT_TERMS: Adult;Affect;Age;aged;Agreement;American;Antibiotics;Appearance;Area;Arthritis;Asthma;Behavior;Biological;Cardiovascular Diseases;Censuses;Child;Childhood;Chocolate;Chronic Disease;Chronic Sinusitis;Collaborations;Communication;Communication difficulty;Communication Disability;Communication impairment;Communities;Community Surveys;Consultations;Coronavirus;cost;Counseling;Coupled;COVID-19 diagnosis;Data;Data Collection;Data Files;data quality;Data Set;Deglutition;Deglutition Disorders;Dental Care;design;Development;Diabetes Mellitus;Diagnosis;disability;Disease;Dose;Drug Prescriptions;Eating;Economics;Education;Emotional;Employment Opportunities;Epidemiology;epidemiology study;Esthesia;Etiology;Evaluation;Event;Excision;Family;feeding;flu;Food;food flavor;Functional disorder;Funding;Genus Vanilla;Head;Health;health care availability;health care service;health disparity;Health Personnel;Health Professional;Health Status;Healthcare;Housing;Hypertension;Impairment;improved;Individual;Inflammation;Injury;Institutional Review Boards;instrument;interest;Intervention;Interview;Interviewer;Language;Language disability;Language Disorders;Licensing;Life;lifestyle factors;Link;Maintenance;malformation;Malignant Neoplasms;Measurement;Measures;Medical;Medical Care Team;member;metallicity;Modernization;Nasal Polyps;National Health Interview Survey;National Institute on Deafness and Other Communication Disorders;Neurologic;Nutritional;Occupational;Occupations;Odors;older adult;Olfaction Disorders;Olfactory dysfunction;operation;Operative Surgical Procedures;Oral cavity;Pathologist;Patients;Persons;Pharmaceutical Preparations;Physicians;Polyps;Population;population survey;Preparation;Prevalence;psychologic;Publications;Pulmonary Emphysema;quality assurance;Quality of life;Questionnaire Designs;Questionnaires;Reporting;Research;Research Personnel;Risk;risk mitigation;Sampling;SARS-CoV-2 infection;screening;Series;Services;Smell Perception;Smoker;smoking cessation;social;Social Interaction;Societies;sociodemographic factors;Specialist;Speech;Speech Disorders;Speech Sound;Speech-Language Pathology;Steroids;Strawberries;Stroke;Stuttering;Surgeon;Surveys;sweet taste perception;Symptoms;Taste Disorders;Taste Perception;Technology;Testing;Time;Training;Travel;United States;United States National Center for Health Statistics;United States National Institutes of Health;Voice;Voice Disorders;web site;Weight;Work;Xerostomia

PROJECT_TITLE: CDC-NCHS-NHIS Taste & Smell Questionnaire Supplement


ADMINISTERING_IC: HD

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Prevention

ORG_CITY: MENLO PARK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: SRI INTERNATIONAL

ORG_STATE: CA

PI_NAMEs: PARMAN, TOUFAN  (contact)

PROJECT_TERMS: Archives;Biological;Biological Testing;Contraceptive Agents;Contraceptive methods;Contractor;Data;data communication;Data Storage and Retrieval;Databases;Equipment;Equipment and supply inventories;Interruption;Maintenance;men;Mission;National Institute of Child Health and Human Development;new product development;preclinical development;product development;Program Development;programs;Research;Woman

PROJECT_TITLE: BIOLOGICAL TESTING FACILITY - ADMINISTRATION, MANAGEMENT, AND DATABASE MAINTENANCE FOR CONTRACEPTION RESEARCH


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Neurosciences

ORG_CITY: RICHMOND

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Astrocytes, the most abundant glial cells in the central nervous system, perform a multitude of evolutionary conserved functions including, metabolic support to neurons, regulating blood-brain barrier, and modulating synapse-formation, -function and -plasticity, and are crucial in maintaining normal brain homeostasis. Dynamic crosstalk between astrocytes and neuronal synapses modulates most if not all of these functions, yet the molecular mechanism of neuron-astrocyte cross-communication at the synapse is largely untapped. Based on our preliminary studies, we propose a novel mechanism of neuron-astrocyte crosstalk at the synapse via S1P/S1PR1 signaling that regulates astrocyte function and neuronal synapse formation, function and plasticity.

PI_NAMEs: SINGH, SANDEEP KUMAR (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Astrocytes;Blood - brain barrier anatomy;Brain;Brain Diseases;Brain Pathology;Calcium;Central Nervous System;Communication;Coupled;Data;Development;Drug Targeting;Excitatory Synapse;Glutamates;Glypican;Goals;GTP-Binding Proteins;hevin;Homeostasis;In Vitro;in vivo;insight;Knock-out;Knowledge;Link;Mediating;Metabolic;Molecular;Morphogenesis;Morphology;Mus;Nervous System Disorder;neural circuit;Neuroglia;neuronal circuitry;neuronal growth;neuronal survival;Neurons;neuropathology;neurotransmission;novel;Process;Protein Secretion;Proteins;Publishing;receptor;Research;Role;Shapes;Signal Pathway;Signal Transduction;Sphingolipids;sphingosine 1-phosphate;sphingosine kinase;Sphingosine-1-Phosphate Receptor;Structure;Synapses;synaptic function;synaptogenesis;Testing;thrombospondin 4;Thrombospondins;vesicular glutamate transporter 2

PROJECT_TITLE: S1P-S1PR1 in bidirectional Neuron-Astrocyte communications

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: DAYTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: WRIGHT STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Despite much effort to identify mechanisms underlying amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration dementia (FTLD or FTD), effective treatments remain elusive. Motoneuron (MN) excitability dysfunction is tightly linked to disease pathology, yet to date, excitability dysregulation has not been examined in the recent rNLS8 mouse model, which recapitulates pathologic TDP43 inclusions seen in MNs in >90% of ALS patients and in FTD patients. This proposal is relevant to public health because it will examine excitability dysregulation in this highly relevant model of ALS/FTD.

PI_NAMEs: ELBASIOUNY, SHERIF M (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: ALS patients;Amygdaloid structure;Amyotrophic Lateral Sclerosis;Animal Model;Area;Automobile Driving;Brain;Cessation of life;cholinergic;comorbidity;Compensation;Conflict (Psychology);Corpus striatum structure;Data;Dementia;Disease;DNA-Binding Proteins;Down-Regulation;Drug Targeting;effective therapy;Electrophysiology (science);Event;Exhibits;FDA approved;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Grant;Hippocampus;Hyperactivity;Immunohistochemistry;Individual;Ion Channel;Knowledge;Kv2.1 channel;Life;Link;Measures;Modeling;Motor Neurons;mouse model;Mus;Muscle fasciculation;mutant;Mutation;neuron loss;neuronal excitability;Neurons;neuroprotection;new therapeutic target;novel;Paralysed;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;Play;protein TDP-43;Public Health;Reporting;Research;response;Riluzole;Role;Severities;Spinal;Spinal Cord;Superoxide Dismutase;Symptoms;Synapses;synaptic function;TDP-43 aggregation;Western Blotting

PROJECT_TITLE: Excitability dysfunction mechanisms underlying the TDP43-dependent ALS and FTD pathogenesis

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: ALBANY

ORG_NAME: ALBANY MOLECULAR RESEARCH, INC.

ORG_STATE: NY

PI_NAMEs: SCHLAGER, HEIDI  (contact)

PROJECT_TERMS: Acinetobacter;Antimicrobial Resistance;Bacterial Antibiotic Resistance;Biological;Chemistry;Combating Antibiotic Resistant Bacteria;Communicable Diseases;Development;Development Plans;Drug Kinetics;Evaluation;In Vitro;in vivo;Interventional Agent Development;Lead;manufacture;pathogen;pre-clinical;process optimization;product development;programs;Pseudomonas aeruginosa;Safety;scale up;Services;Therapeutic;therapeutic development;Toxicology;Toxin

PROJECT_TITLE: Task C24: Process Optimization and Scale Up of an Antibiotic-Resistant Bacterial Agent


NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: NORTH LIBERTY

ORG_NAME: JMI LABORATORIES

ORG_STATE: IA

PI_NAMEs: ARENDS, RYAN  (contact)

PROJECT_TERMS: Advanced Development;Anti-Bacterial Agents;Bacteria;Bacterial Antibiotic Resistance;Biological Assay;Collection;combat;Contracts;Development;in vitro testing;Maintenance;therapeutic development;Toxin

PROJECT_TITLE: Task A27: Antibacterial MICs of a Gram-Negative Targeted Compound Collection


PROJECT_TERMS: Advanced Development;Anti-Bacterial Agents;Bacteria;Bacterial Antibiotic Resistance;Biological Assay;combat;Contracts;Development;Disease;Gram-Negative Bacteria;Gram-Positive Bacteria;In Vitro;in vitro testing;Maintenance;pathogen;Resistance;screening;therapeutic development;Toxin

PROJECT_TITLE: Task A28: In Vitro Screening for Antibacterial Activity Against Disease Pathogens


ORG_CITY: NEW TAIPEI CITY

ORG_COUNTRY: TAIWAN

ORG_FIPS: TW

ORG_NAME: PHARMACOLOGY DISCOVERY SERVICES TAIWAN, LTD.

PI_NAMEs: MIESEL, LYNN  (contact)

PROJECT_TERMS: Bacterial Antibiotic Resistance;Bacterial Drug Resistance;Bacterial Infections;bacterial resistance;Combating Antibiotic Resistant Bacteria;Contracts;Development;Evaluation;infectious disease model;mouse model;Testing;therapeutic development

PROJECT_TITLE: Task A94: Testing in Murine Models of Antibiotic-Resistant Bacterial Infection


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Sexually Transmitted Infections;Vaccine Related

PROJECT_TERMS: antibiotic resistant infections;Bacterial Drug Resistance;bacterial resistance;Combating Antibiotic Resistant Bacteria;Contracts;Development;Drug-resistant Neisseria Gonorrhoeae;Evaluation;infectious disease model;mouse model;Neisseria gonorrhoeae;therapeutic development;Vaccines

PROJECT_TITLE: Task A100: Mouse Model of Neisseria Gonorrhoeae Antibiotic Resistant Infection


PI_NAMEs: MIRASILAS, JON  (contact)

PROJECT_TERMS: Antibiotic Resistance;Antimicrobial Resistance;Biological;Chemistry;Combating Antibiotic Resistant Bacteria;Communicable Diseases;Development;Development Plans;Drug Kinetics;Evaluation;In Vitro;in vivo;Interventional Agent Development;Lead;manufacture;pathogen;pre-clinical;product development;programs;Safety;Services;Staphylococcus aureus;Therapeutic;therapeutic development;Toxicology;Toxin

PROJECT_TITLE: Task D16: Nonclinical Services for the Development of Interventional Agents for Antibiotic Resistant Infectious Diseases


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Disorders;Cancer;Colorectal Cancer;Digestive Diseases;Immunotherapy;Neurosciences

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PI_NAMEs: HAYDEN GEPHART, MELANIE  (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: 3-Dimensional;Affect;Air;Animal Model;Anti-CD47;Antigen Presentation;Architecture;Biological Assay;Bone Marrow Transplantation;Brain;Brain Neoplasms;Busulfan;cancer cell;CD47-SIRPα;Cell Communication;Cell Death;Cells;Cerebrospinal Fluid;Circulation;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;colorectal cancer metastasis;Complex;CRISPR library;CSF1 gene;cytokine;Data;Disease Progression;Disseminated Malignant Neoplasm;Distant;Epithelium;Evaluation;Exhibits;Extracellular Matrix;Gene Modified;Generations;Genes;Growth;Human;human disease;Immune;immune cell infiltrate;Immunologic Surveillance;Immunological Models;Immunotherapy;implantation;in vitro Model;Inflammatory;Inflammatory Response;innovation;Interleukin-6;Intrinsic factor;Invaded;Knock-out;Knowledge;Ligands;Liquid substance;Macrophage;Macrophage Activation;Malignant Neoplasms;Measures;Mediating;Messenger RNA;Metalloproteases;Metastatic malignant neoplasm to brain;Methods;Microglia;migration;Modeling;Monitor;mortality;multidisciplinary;Mus;Myeloid Cells;Neoplasm Metastasis;neoplastic cell;Neurologic;neuropathology;novel;novel strategies;Organoids;Phagocytosis;Phenotype;Population;Positioning Attribute;Primary Neoplasm;Production;Prognosis;Proliferating;Property;Protocols documentation;Publishing;receptor;Recurrence;Resistance;RNA analysis;Role;Sampling;Signal Transduction;single-cell RNA sequencing;small molecule;T-Cell Activation;T-Lymphocyte;Technology;Testing;Therapeutic;transcriptome;tumor;Tumor Cell Invasion;Tumor Immunity;tumor microenvironment;tumor progression;Tumor-associated macrophages;tumor-immune system interactions;weapons

PROJECT_TITLE: Investigate and inhibit microglia support of brain metastases


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: NEW YORK

ORG_NAME: GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT

PI_NAMEs: FOTOUHI, NADER  (contact)

PROJECT_TERMS: Advanced Development;antimicrobial resistant infection;Bacterial Drug Resistance;bacterial resistance;biodefense;candidate selection;Chemistry;Clinical assessments;Combating Antibiotic Resistant Bacteria;efficacy evaluation;Emerging Communicable Diseases;lead optimization;manufacture;Mycobacterium tuberculosis;pathogen;pre-clinical;product development;research and development;Research Support;safety assessment;Therapeutic;therapeutic candidate;therapeutic development

PROJECT_TITLE: Development of Therapeutic Candidates for Biodefense, Antimicrobial Resistant (AMR) Infections and Emerging Infectious Diseases


NIH_SPENDING_CATS: Cancer;Clinical Research;Dissemination and Implementation Research;Immunization;Prevention;Vaccine Related

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PI_NAMEs: IWELUNMOR, JULIET  (contact)

PROGRAM_OFFICER_NAME: PARASCANDOLA, MARK

PROJECT_TERMS: Adoption;Africa;anti-cancer research;apprenticeship;Awareness;Cancer Burden;Cancer Control;Cancer Control Research;Cancer Science;cancer type;cancer vaccination;Cancer Vaccines;career;Cervical;Cessation of life;Clinical;cohort;Collaborations;Communities;community organizations;Country;Creativeness;crowdsourcing;design;E-learning;Equity;evidence base;Evidence based intervention;experience;Faculty;faculty mentor;Fostering;Funding;Geography;Goals;Grant;Health;Healthcare;Hepatitis B Vaccines;Human Papilloma Virus Vaccine;Hybrids;Immunization;implementation research;implementation science;improved;Individual;innovation;Institution;Institutionalization;Intervention;Lead;learning community;Malignant Neoplasms;Medical Research;Mentors;Mentorship;Methods;National Institute of Child Health and Human Development;next generation;Nigeria;Nigerian;peer support;Persons;Pilot Projects;Policies;population health;prevent;Primary carcinoma of the liver cells;programs;prototype;recruit;Research;Research Personnel;Research Support;research to practice;Resources;Science;Series;Services;Site;skills;social;supportive environment;Talents;Training;training opportunity;Travel;United States National Institutes of Health;Vaccines;virtual;Writing;Youth

PROJECT_TITLE: Research and Capacity Building Core


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Kinases are an important class of proteins that are currently targeted by 77 small molecule FDA-approved drugs, more than 85% of which can be used in cancer therapy. Despite them performing essential roles in the brain, modulating kinases to treat neurodegeneration has not been the focus of most programs, leaving their potential to alter or halt the progression of these diseases unknown. This project will create high-quality chemical tools that can be used in animals and will allow researchers around the world to more definitively characterize the suggested role that one of these important kinases plays in driving Alzheimer’s disease pathology and confirm whether it is a good therapeutic target for Alzheimer’s disease.

PI_NAMEs: AXTMAN, ALISON DONNELLY (contact)

PROGRAM_OFFICER_NAME: GROTHAUS, PAUL G

PROJECT_TERMS: 3xTg-AD mouse;Address;Adult;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease therapy;Amyloid;analog;Animal Model;Animals;Anti-Inflammatory Agents;Area;Automobile Driving;Behavioral;Biological Assay;Biology;Blood;blood-brain barrier penetration;Brain;Cancer cell line;cancer therapy;casein kinase II;Cell model;Cells;cellular targeting;Chemicals;Clinical;Clinical Research;Collaborations;Communities;Computer software;cytokine;Data;Dementia;design;Development;Disease;Disease Progression;Dose;Drug Kinetics;Drug Targeting;effective therapy;enzyme activity;Evaluation;Exhibits;experience;FDA approved;Goals;Half-Life;Homeostasis;Human;Human Genome;human old age (65+);human stem cell-derived;human stem cells;imaging study;improved;In Vitro;in vivo;in vivo Model;inhibitor;interest;Investigation;kinase inhibitor;Kinetics;knock-down;Lead;Libraries;lipophilicity;Liver Microsomes;Malignant Neoplasms;Metabolic;Microglia;Microsomes;Modeling;mouse model;multidisciplinary;Mus;Mutation;Nerve Degeneration;Neurodegenerative Disorders;neurofibrillary tangle formation;neuroinflammation;Neurons;novel;Oncology;overexpression;Pathogenicity;Pathologic;Pathway interactions;Penetrance;Penetration;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphotransferases;Play;Process;programs;Property;Protein Kinase;Proteins;Publications;Publishing;Regulation;Research;Research Personnel;response;Role;screening;Signal Pathway;Signal Transduction;simulation;small molecule;Solubility;stem cells;Structure;Symptoms;Synapses;Testing;Therapeutic;therapeutic target;Time;tool;Toxic effect;translation to humans;Validation

PROJECT_TITLE: Optimization of a potent and cell active CK2 chemical probe for Alzheimer's disease therapy

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: STONY BROOK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Narrative: The class-IIa histone deacetylases (class-IIa HDACs) are a key component of the epigenetic machinery in Alzheimer's disease (AD), a devastating neurodegenerative disease. Therefore, developing and validating a novel class-IIa HDAC PET imaging probe will have a significant positive impact on human health by informing on AD progression and may detect AD at an early time point when therapy may be most effective. The success of our imaging studies may delineate a novel role for class-IIa HDAC in pathophysiology and progression of AD and may identify class-IIa HDAC as a novel druggable target in AD.

PI_NAMEs: TURKMAN, NASHAAT  (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: abeta accumulation;Acceleration;Address;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease therapy;Amyloid beta-Protein;Automation;Autopsy;Autoradiography;Binding;Biodistribution;Brain;Brain region;brain tissue;Central Nervous System;Central Nervous System Diseases;Clinical;clinical translation;Clinical Trials;cognitive performance;course development;Cyclic GMP;Data;Dementia;density;Development;diagnostic tool;Disease;Disease Progression;Drug Targeting;druggable target;Early Diagnosis;Ensure;Epigenetic Process;Exhibits;Exposure to;Family suidae;first-in-human;Fostering;Functional disorder;Health;Histone Acetylation;Histone Deacetylase;Human;human subject;human tissue;Human Volunteers;imaging probe;imaging study;Immunohistochemistry;Impaired cognition;improved;In Vitro;in vivo;in vivo imaging;Incentives;Institutional Review Boards;interest;Investments;kinetic model;Maintenance;Manuals;Measures;Metabolism;molecular imaging;Molecular Probes;Names;National Institute of Mental Health;Neurodegenerative Disorders;new therapeutic target;novel;novel diagnostics;Organ;Pathogenicity;Pharmacological Treatment;Positron-Emission Tomography;Preparation;Production;Psychotropic Drugs;Public Health;Radiation;Radiolabeled;radioligand;Radiometry;Radiopharmaceuticals;Rattus;Reproducibility;Research;Role;Running;screening program;Senile Plaques;Stains;success;tau aggregation;tau Proteins;Testing;Therapeutic;therapy development;Time;Toxic effect;Tracer;translation to humans;Translational Research;Validation;β-amyloid burden

PROJECT_TITLE: Development of class-IIa HDAC targeting PET probes for molecular imaging of disorders of the CNS

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Pediatric

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE – Overall. People with Down syndrome are strongly predisposed to develop a wide range of comorbidities that shorten their lifespan and decrease their quality of life, such as Alzheimer’s disease, congenital heart disease, leukemias, autoimmune disorders, and diverse neurological conditions. The proposed activities under this project seek to create a world-class resource for collaborative discovery, data sharing, data access, and integrative analysis that would enable novel investigations into all DS comorbidities across the lifespan and further integrating across datasets for related diseases occurring in the general population, thus paving the way for a precision medicine approach to DS. Furthermore, this resource and associated platforms will also have broader impacts by empowering physicians, educators, government officials, and advocates with the tools required to elicit evidence- based transformative action in the clinic, the classroom, the government, and society at large.

PI_NAMEs: CARROLL, ROBERT J;DIGIOVANNA, JACK ;ESPINOSA, JOAQUIN M.;FERRETTI, VINCENT ;HAENDEL, MELISSA A;RESNICK, ADAM CAIN (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: Acceleration;Advocacy;Advocate;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid Beta A4 Precursor Protein;Area;autism spectrum disorder;Autoimmune Diseases;Automobile Driving;bench to bedside;biobank;Biomedical Research;Child;Chromosome 21;Chromosomes;Clinic;Clinical;Cohort Studies;Collaborations;Communities;community empowerment;comorbidity;Complex;congenital heart abnormality;Data;data access;Data Coordinating Center;data ecosystem;data integration;data management;data modalities;data portal;data resource;Data Set;data sharing;data sharing networks;design;Development;Discipline;Disease;diverse data;Down's Syndrome;Ecosystem;Education;empowerment;Ensure;Environment;Environmental Risk Factor;epidemiology study;Epigenetic Process;Epilepsy;evidence base;Family;General Population;Genetic Diseases;Genetic Variation;Goals;Government;Government Officials;Human;Human Biology;Individual;innovation;interoperability;Intuition;Investigation;leukemia;Life Cycle Stages;Life Expectancy;life span;lifestyle factors;Link;Malignant Neoplasms;metabolome;Methods;microbiome;Mission;Multiomic Data;National Heart, Lung, and Blood Institute;Neurologic;novel;novel diagnostics;novel therapeutics;outreach;Participant;Pathogenicity;Persons;Phenotype;Physicians;Population;precision medicine;prenatal;Proteome;Quality of life;Research;Resources;response;Risk;Schools;Scientist;Security;Societies;Solid;Surveys;synergism;Technology;Time;timeline;tool;Training;transcriptome;United States National Institutes of Health;Variant;virtual

PROJECT_TITLE: Ensuring Data Compliance and Security for the INCLUDE Data Coordinating Center in Response to Emerging NIH/NHLBI Platform Environment Requirements


PROJECT_TERMS: Acceleration;Advocacy;Advocate;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid Beta A4 Precursor Protein;Area;autism spectrum disorder;Autoimmune Diseases;Automobile Driving;bench to bedside;biobank;Biomedical Research;Child;Chromosome 21;Chromosomes;Clinic;Clinical;Cohort Studies;Collaborations;Communities;community empowerment;comorbidity;Complex;congenital heart abnormality;Data;data access;Data Coordinating Center;data ecosystem;data integration;data management;data modalities;data portal;data resource;Data Set;data sharing;data sharing networks;design;Development;Discipline;Disease;diverse data;Down's Syndrome;Ecosystem;Education;empowerment;Ensure;Environmental Risk Factor;epidemiology study;Epigenetic Process;Epilepsy;evidence base;Experimental Models;Family;General Population;Genetic Diseases;Genetic Variation;Goals;Government;Government Officials;Human;Human Biology;Individual;innovation;interoperability;Intuition;Investigation;leukemia;Life Cycle Stages;Life Expectancy;life span;lifestyle factors;Link;Malignant Neoplasms;metabolome;Methods;microbiome;Mission;Multiomic Data;Neurologic;novel;novel diagnostics;novel therapeutics;outreach;Participant;Pathogenicity;Persons;Phenotype;Physicians;Population;precision medicine;prenatal;Proteome;Quality of life;Research;Resources;Risk;Schools;Scientist;Societies;Solid;Surveys;synergism;Technology;Time;timeline;tool;Training;transcriptome;United States National Institutes of Health;Variant;virtual

PROJECT_TITLE: DCC Supplement for Experimental Models Portal


ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BIRMINGHAM

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Narra�ve:  Brain diseases such as demen�a and Alzheimer’s disease are a rapidly growing health problem in the United States, and growing evidence shows that the re�na, at the back of the eye, is also being damaged by these diseases. In our proposed experiments we will measure re�nal func�on and anatomy in a mouse model of Alzheimer’s disease, and we will perform parallel tests on human subjects: young, old and in the beginning stages of demen�a. Our goal is to iden�fy and reﬁne a non-invasive, inexpensive clinical test to determine the earliest measurable changes indica�ng the presence or progression of the disease based on these eye tests.

PI_NAMEs: KRAFT, TIMOTHY W (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: abeta deposition;Acceleration;Affect;Age;Age Months;age-related disease;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease test;Anatomy;Animal Model;APP-PS1;Area;Autopsy;Back;Blindness;Blood Vessels;Brain;Brain Diseases;capillary bed;Cause of Death;Cell Density;Cell Physiology;Cell Volumes;Cells;Central Nervous System Diseases;Cerebral cortex;Cognitive;Color;Communities;Contrast Sensitivity;curative treatments;Data;Dementia;density;Diagnosis;Diagnostic;Disease;Disease Progression;Early Diagnosis;Early identification;Early Onset Alzheimer Disease;effective therapy;Elderly;Electroretinography;experimental study;Eye;Family;Financial cost;Functional disorder;functional loss;Ganglia;ganglion cell;Ganglion Cell Layer;Genes;Glutamates;Goals;Health;Health Care Costs;Health Personnel;Healthcare Systems;high risk;Histologic;Histopathology;Human;human subject;human tissue;Impaired cognition;improved;Individual;Knowledge;Link;loss of function;macula;Macular degeneration;Maps;Measurable;Measures;Metabolic;mild cognitive impairment;Molecular;mouse model;Mus;Nerve Tissue;Nervous System Trauma;Neurologic;Neurons;normal aging;Normal Range;novel;novel marker;Outcome;outer plexiform layer;Pathologic;Patients;Pattern;Persons;Physiological;Population;pre-clinical;preventive intervention;prospective;Proteins;psychologic;Public Health;recruit;Reporting;Research;research clinical testing;response;Retina;Retinal Ganglion Cells;ribbon synapse;Risk;Rod;Rodent Model;Same-sex;Sensitivity and Specificity;sex;Signal Transduction;social;Structure;Synapses;synaptic function;Techniques;Testing;therapeutic effectiveness;Therapeutic Intervention;Tissue Sample;United States;Vision;visual stimulus;Work

PROJECT_TITLE: Retinal Manifestations of Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-P(81)S]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: The liver controls whole-body metabolism, and disease states such as pre-diabetes, type 2 diabetes and non- alcoholic fatty liver disease arise from disorders in liver metabolism. We identified a critically important sugar transporter that regulates liver metabolism, and a naturally-occurring disaccharide that acts upon this sugar transporter to improve liver and whole-body metabolism, including enhancing the body’s ability to burn calories and to dispose of fat within the liver. The goal of this project is to understand precisely how this sugar transporter regulates liver and whole-body metabolism, and to define the mechanism of action of our index drug to inform new, safe therapies against diabetes and fatty liver disease.

PI_NAMEs: DEBOSCH, BRIAN JESSE (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TITLE: Leveraging glucose transport and the adaptive fasting response to modulate hepatic metabolism

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Precision Medicine;Women's Health Research

PI_NAMEs: BASSIK, MICHAEL C (contact)

PROGRAM_OFFICER_NAME: NADEAU, CHRISTINE FRANCES

PROJECT_TERMS: 3-Dimensional;adaptive immune response;anti-cancer;anticancer activity;biomarker driven;Breast;Breast Cancer Cell;Breast Cancer cell line;breast cancer progression;Breast Cancer Risk Factor;cancer cell;Cancer Model;Cancer Patient;cancer therapy;Candidate Disease Gene;candidate identification;CD47 gene;Cell Communication;Cell Line;Cells;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR interference;CRISPR screen;CRISPR-mediated transcriptional activation;Dependence;Development;differential expression;Drug resistance;Drug Targeting;druggable target;Effectiveness;Engineering;Estrogen receptor positive;Exhibits;experimental study;Fluorescent Probes;Gene Combinations;Gene Expression;Gene Expression Profile;Gene Targeting;Genes;Genetic;Genetic Transcription;genome-wide;Genomics;Growth;high risk;hormone therapy;Immune Evasion;Immune system;Immunosuppression;Immunotherapy;improved;In Vitro;in vivo;Individual;Infiltration;Macrophage;Magnetism;Malignant Breast Neoplasm;Malignant Neoplasms;mammary epithelium;Mass Spectrum Analysis;MCF10A cells;MCF7 cell;Measurement;Measures;Mediating;Metastatic breast cancer;Modeling;Molecular;Nature;Neoplasm Metastasis;neoplastic cell;next generation;novel;Organoids;Outcome;overexpression;Patients;Phagocytes;Phagocytosis;Phenotype;Post-Translational Protein Processing;Process;Property;Proteins;Proteomics;receptor;Relapse;relapse risk;Repression;Resistance;Resistance development;resistance mechanism;Role;sialylation;Signal Transduction;spheroids;Subgroup;System;targeted treatment;Testing;Therapeutic;therapeutic target;therapy resistant;three dimensional cell culture;transcriptomics;Trastuzumab;treatment response;tumor;Tumor Escape;tumor initiation;tumor microenvironment;tumor progression;Tumor-associated macrophages;tumorigenesis

PROJECT_TITLE: Project 3: Systematic characterization of factors controlling breast cancer progression and resistance


ORG_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

PROJECT_TERMS: Adopted;Age;aged;Aging;Agreement;AIDS prevention;Area;Award;Behavior assessment;Budgets;Calendar;Categories;Communication;Communities;computerized data processing;Consult;Consultations;Contraceptive methods;Contraceptive Usage;Contracts;Cost efficiency;Data;data cleaning;Data Collection;Data Files;Decision Making;design;Development;Disclosure;Family;Family health status;Family Planning;Feedback;Fertility;Funding;Funding Agency;Geography;Growth;Health Planning;HIV Infections;HIV/STD;Household;improved;Infertility;Internet;Interview;Maternal Health;meetings;men;National Institute of Child Health and Human Development;Never Married;perinatal health;Periodicals;Persons;Planned Pregnancy;Policies;Population;Preparation;Procedures;Program Development;programs;Progress Reports;Public Domains;Published Comment;Questionnaires;reproductive;Reproductive Health;Respondent;Risk Factors;Sampling;Schedule;sexual and reproductive health;Sexually Transmitted Diseases;social culture;Staff Development;STI prevention;Surveys;symposium;Telephone;Time;trend;United States National Center for Health Statistics;Update;web page;Woman;women's reproductive health;Writing

PROJECT_TITLE: NATIONAL SURVEY OF FAMILY GROWTH (NSFG)


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE The androgen receptor is a type I nuclear hormone receptor and master transcription factor responsible for differentiation and development of the male phenotype. Its hyperactivation is associated with multiple diseases, including metastatic prostate cancer, androgenetic alopecia, androgen insensitivity syndrome, and Kennedy’s disease. This proposal seeks to understand the mechanism of androgen receptor regulation and determinants of its aberrant activity using biochemical, structural, and cellular methods, which can facilitate the development of novel androgen receptor inhibitors and lend mechanistic insight towards other related nuclear hormone receptors.

PI_NAMEs: WASMUTH, ELIZABETH VICTORINA (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Acceleration;Affinity;Androgen Antagonists;androgen independent prostate cancer;Androgen Receptor;Androgen-Insensitivity Syndrome;Androgens;Architecture;Atomic Force Microscopy;Binding;Biochemical;Biological;Biological Assay;Biology;Cancer Biology;career;cell growth;Cell Line;Cells;Cellular Morphology;ChIP-seq;Chromatin;cofactor;Communication;Complex;computerized data processing;Consensus;Cryoelectron Microscopy;data acquisition;Dedications;design;Development;Dimerization;Disease;Dissection;DNA;DNA Binding;DNA Binding Domain;Drug Targeting;Electron Microscopy;Electrons;enzalutamide;Etiology;experience;flexibility;functional outcomes;Generations;genetic corepressor;Genetic Transcription;Global Change;Glucocorticoid Receptor;Goals;Growth;Health;human disease;improved;In Vitro;in vivo;inhibitor;innovation;insight;Joints;Kennedy Syndrome;Knowledge;Laboratories;Leadership;Lentivirus;Ligand Binding Domain;Maintenance;male;Male Pattern Baldness;Malignant neoplasm of prostate;Mediating;Memorial Sloan-Kettering Cancer Center;Metastatic Prostate Cancer;Methods;Mineralocorticoid Receptor;Modeling;Molecular;Molecular Conformation;mutant;Mutate;Mutation;N-terminal;National Institute of General Medical Sciences;Negative Staining;novel;Nuclear Hormone Receptors;Nucleoproteins;Output;particle;Phenotype;Phenotypic Sex;post-doctoral training;Process;Progesterone Receptors;Prostate;prostate cancer cell;protein protein interaction;protein purification;Proteins;Receptor Activation;receptor binding;Receptor Inhibition;Receptor Signaling;Recombinant Proteins;Recombinants;Regulation;Reporter;Reporting;Research;Research Personnel;Resolution;Running;Sex Differentiation;Sexual Development;Site;skills;Stanolone;structural biology;structural determinants;Structural Models;Structure;Surface;System;Technology;Testing;Testosterone;three-dimensional modeling;Training;Transactivation;Transcript;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;Universities;Validation;Variant;Work;X-Ray Crystallography

PROJECT_TITLE: Biochemical, structural and molecular dissection of androgen receptor transcriptional activity


NIH_SPENDING_CATS: Clinical Research;Genetics;Maternal Health;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE Spontaneous preterm birth is a leading cause of neonatal morbidity and mortality, yet we lack the means to diagnose it in advance, treat, or prevent it, especially in women giving birth for the first time. We will analyze samples from one of the best-phenotyped cohorts of nulliparous pregnant women, the nuMoM2b study, providing the largest sample size of its kind along with detailed clinical data affording a nuanced view of prematurity. Our study will identify new biomarkers for early identification of preterm birth, and potential mechanisms underlying it, through a high-resolution investigation of the microbes and small molecules in the female reproductive tract.

PI_NAMEs: KOREM, TAL  (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: 16S ribosomal RNA sequencing;adverse pregnancy outcome;Affect;Algorithms;Biological;Biological Markers;biomarker identification;Cervix Incompetence;Characteristics;Clinical;clinical application;Clinical Data;clinical translation;cohort;Communities;computer framework;Data;Data Analyses;Data Set;Demography;Detection;Diagnosis;Early Diagnosis;Early identification;Early treatment;Ecosystem;Etiology;experience;female reproductive tract;First Births;First Pregnancy Trimester;Geography;Goals;Growth;gut microbiome;Heterogeneity;High-Risk Pregnancy;host microbiome;innovation;insight;Investigation;Knowledge;lens;Measures;Mediator;Medical;Metabolic;Metabolic Pathway;Metabolism;metabolome;metabolomics;metagenome;metagenomic sequencing;Metagenomics;Methods;Microbe;microbial;Microbial Genetics;microbial genomics;Microbial Taxonomy;microbiome;microbiome analysis;microbiome research;Modeling;Multicenter Trials;neonatal morbidity;Neonatal Mortality;Nulliparity;Pathology;personalized risk prediction;Phenotype;Pregnancy;Pregnancy Outcome;Pregnant Women;premature;Premature Birth;preterm premature rupture of membranes;Prevalence;prevent;Property;Race;reproductive tract;Research;Research Personnel;Resolution;Resources;Role;Sample Size;Sampling;Second Pregnancy Trimester;small molecule;Swab;System;Taxonomy;Therapeutic;Third Pregnancy Trimester;Time;United States;Vagina;vaginal microbiome;Variant;Woman

PROJECT_TITLE: A large scale investigation of the vaginal metagenome and metabolome and their role in spontaneous preterm birth

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Hematology;Microbiome;Nutrition;Orphan Drug;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: KANSAS CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: We propose to evaluate the safety, tolerability, and efficacy of a pre- and peri-hematopoietic stem cell transplant (HCT) prebiotic intervention to improve the health of the gut microbiota (bacteria in the gut) and HCT outcomes. Our phase 1/randomized phase 2 clinical trial is accompanied by stool-based correlative studies to understand the impact of our prebiotic intervention on the microbiota and differences in the microbiota that may explain why some patients respond to the prebiotic while others may not; we also include peripheral blood biomarkers to identify potential mechanisms to explain the interaction between the prebiotic, microbiota, and HCT outcomes.

PI_NAMEs: SUNG, ANTHONY  (contact)

PROGRAM_OFFICER_NAME: FRANK, DANIEL J

PROJECT_TERMS: Affect;Allogenic;anti-microbial peptide;Antibiotic Therapy;Antibiotics;Bacteria;bacterial community;Biological Markers;Blood;Blood Circulation;Blood specimen;Butyrates;Cells;chemotherapy;Clinical;Clinical Trials;Colon;conditioning;Correlative Study;Data;design;diagnostic assay;Disease;Dose;Elements;Energy-Generating Resources;Engraftment;Epithelial Cells;Feces;Fiber;Future;Goals;graft vs host disease;gut bacteria;gut health;gut inflammation;gut microbiota;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;immune reconstitution;Immune system;improved;improved outcome;Infection;Inflammation;Infusion procedures;interest;Intervention;Intestines;islet;leukemia;Link;Lymphoma;Malignant - descriptor;Maximum Tolerated Dose;Mediating;Mediator;Metabolic;Metabolism;microbiome;microbiota;microbiota transplantation;Modeling;Monitor;Morbidity - disease rate;mortality;Mus;Natural regeneration;Non-Malignant;Oligosaccharides;Outcome;Patients;peripheral blood;personalized medicine;Phase;phase I trial;Phase I/II Clinical Trial;Phase II Clinical Trials;phase II trial;phase III trial;Placebo Control;prebiotics;primary endpoint;Probiotics;Process;Proteins;Radiation therapy;Randomized;Regulatory T-Lymphocyte;Relapse;Reporting;response;Role;Safety;Sepsis;Shapes;Stem cell transplant;stem cells;stool sample;Symptoms;systemic inflammatory response;T-Cell Development;Tissues;Toxic effect;Translating;Transplant Recipients;Transplantation Conditioning;Volatile Fatty Acids

PROJECT_TITLE: Prebiotics to Optimize the Microbiota and Improve Outcomes of AllogeneicHematopoietic Stem Cell Transplantation


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Machine Learning and Artificial Intelligence

ORG_CITY: LOS ANGELES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narratives Building on our success in using novel cryoEM methods to obtain the first near-atomic resolution structures of viral genomes, the largest human viral particles, and small (~120 kDa) membrane protein complexes, this continuation project aims to make atomic resolution structure determination a routine practice for large and transiently stable biological complexes, particularly endogenous cellular complexes and in situ structures in viral genome packaging and gene transcription processes. These new methods will enable investigators to place individual components (proteins, nucleic acids and lipids) within the context of the larger assembly and to visualize chemical interactions among the parts of the complex at atomic detail. Broadly, structural studies of various macromolecular complexes enabled by these new methods will lead to atomic models, help to understand their mechanisms of action, inform efforts to rationally design drugs and vaccines, and suggest novel targets for therapeutic intervention.

PI_NAMEs: ZHOU, Z HONG (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Achievement;Actins;Address;Amino Acids;Area;bacteriocin;Binding;Biological;Biological Process;biological systems;Biomedical Research;cell motility;Cell Physiology;Cells;Cellular Structures;Chemicals;Classification;Code;Complement;Complex;Computer Models;Computer software;computerized data processing;Computing Methodologies;convolutional neural network;Cryoelectron Microscopy;Cytoskeletal Filaments;Data;deep learning;density;design;Development;Disease;DNA;DNA Viruses;Double Stranded DNA Virus;Double Stranded RNA Virus;Drug Design;Electrons;Erythrocytes;Flagella;Funding;genetic information;Genetic Transcription;Genome;Geometry;Goals;Heart;Human;Image;In Situ;Individual;Investigation;Learning;Lipids;Macromolecular Complexes;Maintenance;Maps;Mass Spectrum Analysis;Membrane Proteins;Methods;Modeling;Molecular;nanomachine;neural network;new therapeutic target;non-Native;novel;nucleic acid structure;Nucleic Acids;Outcome;particle;polymerization;Polymers;Process;programs;protein complex;protein purification;protein transport;Proteins;Proteome;Proteomics;quantum;rational design;reconstruction;Research Personnel;Resistance;Resolution;RNA;RNA Viruses;Rod;routine practice;Scheme;small molecule;Source;structural biology;Structure;success;Techniques;Testing;Therapeutic Intervention;three dimensional structure;tool;Training;Transcription Process;transmission process;Vaccines;Validation;Viral;Viral Genome;Virus;Virus Assembly;Virus Replication;Visualization;X-Ray Crystallography

PROJECT_TITLE: High-Resolution CryoEM Reconstruction of Large Complexes

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Mental Health;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Self-care is an evidence-based strategy that can reduce the high morbidity and mortality associated with heart failure. However, little is known about how to implement self-care for heart failure in low- and middle-income country settings in ways that account for the unique needs of different cultures and contexts. Our study, which is designed to prioritize health equity throughout all phases, will compare the implementation, effectiveness, and cost effectiveness of a digital-first implementation strategy vs. a basic evidence-based package and current standard of care to improve self-care in heart failure.

PI_NAMEs: CAFAZZO, JOSEPH ANTONY;SCHWARTZ, JEREMY IAN (contact);SSINABULYA, ISAAC

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: Address;Adherence;Adoption;Africa South of the Sahara;Algorithms;Area;Cardiac;Caring;Cellular Phone;Center for Translational Science Activities;Cessation of life;Clinical;Clinical effectiveness;Cluster randomized trial;Collaborations;community engaged approach;cost;Cost Analysis;cost effectiveness;Cost Effectiveness Analysis;cost-effectiveness ratio;Country;dashboard;Data;Death Rate;debilitating symptom;design;Diet;digital;digital health;Effectiveness;empowerment;Ensure;Equity;evidence base;Evidence based intervention;Exercise;Goals;Government;Health;health equity;Health Priorities;health related quality of life;Healthcare;Heart failure;Hospital Referrals;Hospitalization;hybrid type 2 design;Hybrids;implementation context;implementation evaluation;implementation facilitation;implementation fidelity;implementation process;implementation science;implementation strategy;implementation/effectiveness;improved;incremental cost-effectiveness;indexing;Inequity;Infrastructure;innovation;insight;International;Internet;Interview;Knowledge;Learning;Location;low and middle-income countries;Maintenance;Mental Health;Metadata;Methods;mHealth;mobile application;Monitor;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Nurses;Outcome;Outpatients;Patient Education;Patient Outcomes Assessments;patient-level barriers;Patients;Pattern;Pharmaceutical Preparations;Phase;Physicians;pilot trial;primary outcome;Process;process evaluation;Protocols documentation;Provider;provider-level barriers;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Reporting;Research Personnel;Secure;Self Care;Service delivery model;Shapes;Site;social determinants;sociodemographic disparity;Solar Energy;standard of care;Structure;symptom management;Symptoms;Syndrome;Time;tool;treatment arm;Uganda;Universities;uptake;Work

PROJECT_TITLE: ImpleMEntation of a Digital-first care deLiverY model for heart failure in Uganda (MEDLY Uganda)

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Prevention;Schizophrenia;Serious Mental Illness;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Newark

ORG_DEPT: NEUROSURGERY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Narrative Schizophrenia is a highly heritable neurodevelopmental disorder, but the mechanisms behind how schizophrenia genetic risk loci function is not clear. Cortical interneurons are substantially affected in schizophrenia and enriched for schizophrenia heritability during development. The proposed study is aimed at identifying schizophrenia risk loci that are active in these neurons during development, which will provide insights on the developmental mechanisms of SCZ risks, and help identify novel therapeutic targets.

PI_NAMEs: CHUNG, SANGMI  (contact)

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: 3-Dimensional;Address;Adult;Affect;ATAC-seq;Autopsy;Biological;Brain;brain cell;brain tissue;cell type;Cells;ChIP-seq;Chromatin;Chromosomes;Code;cohort;Complement;Complex;CRISPR interference;CRISPR-mediated transcriptional activation;Data;Data Set;Development;Developmental Process;differentiation in vitro;Disease;Distal;Early identification;Embryo;Embryonic Development;fetal;Fetal Development;Gene Expression;Gene Expression Profile;gene regulatory network;Generations;Genes;Genetic;genetic makeup;Genetic Risk;Genetic study;Genome;genome wide association study;genome-wide;Genomics;Genotype;Glean;Goals;Heritability;Human;human fetal brain;In Vitro;in vivo;induced pluripotent stem cell;insight;Interneurons;Libraries;Maps;Medial;Methods;migration;Mus;Neurodevelopmental Disorder;Neurons;new therapeutic target;Parvalbumins;Pathologic;Pathway interactions;Patients;pluripotent stem cell differentiation;Population;Procedures;Qualifying;Quantitative Trait Loci;Regulation;Resolution;risk variant;Role;Schizophrenia;schizophrenia risk;Somatostatin;Synapses;Testing;Time;Tissues;Training;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Transplantation;Untranslated RNA;Validation;Variant;Weight;Work

PROJECT_TITLE: Common schizophrenia variants functioning in developmental human cortical interneurons

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Neurodegenerative diseases, including Alzheimer’s disease (AD) and Alzheimer’s disease related dementias (ADRD) are characterized by accumulation of intrinsically disordered proteins (IDPs) and impairment of proteasome-mediated protein degradation. This R36 proposal aims to investigate small molecule 20S proteasome activation as a novel strategy to resolve both pathogenic events. Successful completion of this work will enable the rapid design, development, and identification of 20S proteasome activators, and elucidate the role of 20S proteasome modulation in neurodegenerative diseases as a novel therapeutic strategy for disease treatment.

PI_NAMEs: COLOMBANI-GARAY, DANIEL JOSE (contact)

PROGRAM_OFFICER_NAME: COGLIATI, TIZIANA PAOLA

PROJECT_TITLE: Development of N-acyl fluspirilene mediated proteasome enhancement for the treatment of neurodegenerative diseases

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


NIH_SPENDING_CATS: Mental Health;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: Narrative Human iPSCs can provide unlimited sources of human neurons to study disease mechanisms; but in vitro neuronal cultures lack many important brain components that play crucial roles in neuronal functions. Thus, we will generate brain-region-specific humanized cortical interneuron mice to allow for the study of the role of grafted human neurons in brain circuit and behavioral functions. Such physiological humanized models will facilitate the understanding of cell-type-specific and brain-region-specific disease mechanisms, and the development of novel therapeutics.

PROJECT_TERMS: Ablation;Address;Area;Astrocytes;autism spectrum disorder;Behavior;Behavioral;Behavioral Assay;Biological Models;Blood Vessels;Brain;Brain Diseases;Brain region;Cell Culture Techniques;cell type;Central Nervous System;Chimera organism;cognitive function;cognitive task;cognitive testing;Complex;Data;Development;Disease;disease mechanisms study;Dorsal;Dose;Electrodes;Electrophysiology (science);Environment;experimental study;Failure;Future;Genetic;Graft Survival;Hippocampus;Histologic;Human;human disease;human fetal brain tissue;human induced pluripotent stem cells;Immunohistochemistry;In Vitro;in vivo;in vivo Model;induced pluripotent stem cell;Injections;Interneuron function;Interneurons;Medial;Methods;Microglia;Modeling;Mus;Neurons;neuropsychiatric disorder;novel;novel therapeutics;Oligodendroglia;optogenetics;Pathogenesis;Patients;Phenotype;physiologic model;Physiological;Play;Pluripotent Stem Cells;Population;Prefrontal Cortex;Qualifying;Regulation;restoration;risk variant;Rodent;Rodent Model;Role;Schizophrenia;Slice;Source;stem cells;Synapses;System;Testing;Therapeutic;Titrations;Transplantation;Untranslated RNA;Viral Vector

PROJECT_TITLE: Brain-region-specific humanized cortical interneuron mice

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ADMINISTERING_IC: AR

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The University of Michigan's Program for Scientist Training in Rheumatology Research is designed to prepare four outstanding postdoctoral scientists per year, both MD and PhD, for investigative careers in research related to the rheumatic diseases. The goal is to provide a diverse cohort of trainees essential familiarity with state-of-the-art scientific methodologies and analyses, as well as strong roots in the ethical conduction of research and in embracing a culture of diversity, equity, and inclusion.

PI_NAMEs: KNIGHT, JASON  (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunization;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases;Vaccine Related

PHR: The studies proposed herein are designed to investigate mechanisms of immune evasion following active immunotherapy with brain cancer vaccines. We will test our hypothesis that clinically relevant anti-tumor immunity to glioblastoma (GBM) must have two cellular components: 1) significant infiltration of tumor-specific  tumor-infiltrating lymphocytes (TIL); and 2) blockade of immunosuppressive tumor infiltrating myeloid cell (TIM) function within the tumor microenvironment. We believe that a combination of active vaccination (ATL-DC; to induce T-cell infiltration into tumors), immune checkpoint inhibition (to enhance T cell function), and CSF-1R inhibition (to block suppressive TIM function) may lead to improved outcomes for the treatment of glioblastoma.

PI_NAMEs: PRINS, ROBERT M (contact)

PROGRAM_OFFICER_NAME: HUBBARD, LEAH

PROJECT_TERMS: Active Immunization;Active Immunotherapy;Animals;anti-PD-1;anti-tumor immune response;Ants;Attenuated;Autologous;Brain;Brain Neoplasms;Cancer Vaccines;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Cellular biology;checkpoint inhibition;Chronic;Clinical Trials;clinically relevant;Combination immunotherapy;Combined Modality Therapy;CSF1R gene;dendritic cell vaccination;Dendritic Cells;design;Development;effective therapy;first-in-human;Funding;Glioblastoma;Glioma;Health;Immigration;Immune;Immune Evasion;immune resistance;Immunotherapy;improved outcome;Infiltration;inflammatory milieu;inhibitor;innovation;insight;Malignant neoplasm of brain;Measures;Mediating;Monoclonal Antibodies;Myeloid Cells;Myeloid-derived suppressor cells;neoplasm immunotherapy;neoplastic cell;Newly Diagnosed;novel;Patients;PD-1 blockade;pembrolizumab;Phenotype;Physiologic pulse;preclinical study;programmed cell death protein 1;Recurrence;Resistance;response;Series;T cell infiltration;T cell response;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Translational Research;Treatment outcome;tumor;Tumor Immunity;tumor microenvironment;Tumor-Infiltrating Lymphocytes;vaccination strategy;Virus Diseases

PROJECT_TITLE: Project 1:  Targeting immunotherapy-induced resistance with DC vaccination and PD-1/CSF-1R inhibition


NIH_SPENDING_CATS: Infectious Diseases

PHR: Project narrative Production of small molecules that bind metal ions is important for the survival of microbes and the ability of these microbes to cause infections. We study the reaction mechanisms of the enzymes responsible for the production of a unique copper-containing antibiotic, which is produced by a pathogen that can cause serious hospital-acquired infections. Our mechanistic investigations will advance the understanding of enzyme-catalyzed reactions, provide new tools for biocatalysis, and enable studies of how pathogenic bacteria maintain copper balance during infection.

PI_NAMEs: LI, BO  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: absorption;adenylosuccinate lyase;Amines;Anabolism;analog;Antibiotics;Binding;Biomedical Engineering;Carbon;carboxylate;Catalysis;Chemical Structure;Chemistry;Collaborations;college;Copper;Cysteine;Data;Decarboxylation;Dioxygenases;Drug Metabolic Detoxication;Electron Spin Resonance Spectroscopy;Engineering;Enzyme Kinetics;enzyme mechanism;Enzymes;Equilibrium;Excision;Exhibits;Family;fluopsin;Formates;Fumarates;Heme;human pathogen;Hydrogen;Industrialization;Infection;innovation;insight;Investigation;Ions;Iron;Lifting;Ligand Binding;Ligands;Lyase;Medicine;Metal Ion Binding;Metals;Microbe;microorganism;Monitor;Multi-Drug Resistance;N hydroxylation;Natural Products;Nature;Nitric Oxide;Nosocomial Infections;novel;Oximes;Oxygen;Oxygenases;pathogen;pathogenic bacteria;Pathway interactions;Pharmacologic Substance;Play;Production;Pseudomonas aeruginosa;Reaction;Recycling;Reducing Agents;Roentgen Rays;Siderophores;small molecule;Spectrum Analysis;stoichiometry;structural biology;Structure;Sulfur;Synthesis Chemistry;synthetic biology;Testing;tool;Variant;Virulence;Work

PROJECT_TITLE: Mechanisms of unusual enzymes in the biosynthesis of a copper-containing antibiotic

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Vaccine Related

ORG_CITY: ROCKVILLE

ORG_NAME: FISHER BIOSERVICES, INC.

ORG_STATE: MD

PI_NAMEs: EYLER, DENNIS  (contact)

PROJECT_TERMS: 2019-nCoV;Adherence;Clinical;clinical material;Clinical Research;Clinical Trials;Communicable Diseases;Contracts;Ensure;Good Clinical Practice;good laboratory practice;Good Manufacturing Process;Microbiology;programs;Services;Shipping;Specimen

PROJECT_TITLE: Division of Microbiology and Infectious Diseases (DMID): Clinical Materials Services (CMS), SARS-CoV-2


PHR: Public Health Relevance: Specific Aims: Specific aims include clinical trial support.

PROJECT_TERMS: Adherence;Antibiotic Resistance;Clinical;clinical material;Clinical Research;Clinical Trials;Combating Antibiotic Resistant Bacteria;Communicable Diseases;Contracts;Ensure;Good Clinical Practice;good laboratory practice;Good Manufacturing Process;Microbiology;programs;public health relevance;Services;Shipping;Specimen

PROJECT_TITLE: Division of Microbiology and Infectious Diseases (DMID) Clinical Materials Services: Antibiotic Resistant Clinical Studies


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PI_NAMEs: HEILHERKER, TYSON  (contact)

PROJECT_TERMS: Adjuvant;Adjuvanticity;Agonist;analog;Animal Model;Antigens;Austria;Boston;Cells;Chemistry;Contractor;cytokine;Development;Disease;efficacy study;Family suidae;Ferrets;Formulation;good laboratory practice;Good Manufacturing Process;Hemagglutinin;high throughput screening;Human;Immune;immune activation;Immune signaling;immunogenicity;In Vitro;in vivo;in vivo Model;Infection;Influenza;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H3N2 Subtype;influenza virus strain;influenza virus vaccine;Intervention;Investigational New Drug Application;Leukocytes;Licensing;Malignant Neoplasms;manufacture;Mediating;Mus;novel;Pattern recognition receptor;Pediatric Hospitals;Process;Production;Program Development;programs;Proteins;Readiness;Research Activity;response;scale up;small molecule;System;TLR7 gene;Vaccination;Vaccine Adjuvant;vaccine immunogenicity;Vaccines;Wisconsin

PROJECT_TITLE: VACCINES ADJUVANT DEVELOPMENT PROGRAM IN INFECTIOUS AND IMMUNE MEDIATED DISEASES


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PI_NAMEs: URDAHL, KEVIN  (contact)

PROJECT_TERMS: Animals;design;Goals;HIV;HIV Seronegativity;HIV Seropositivity;Human;human subject;Immune;Immune Evasion;Immune response;Immune Targeting;Immunity;Immunologics;improved;multidisciplinary;Mus;Mycobacterium Infections;Mycobacterium tuberculosis;non-tuberculosis mycobacteria;nonhuman primate;programs;protective pathway;Research Activity;Research Personnel;response;SIV;Tissues;Tuberculosis;Tuberculosis Vaccines;vaccine strategy;vaccine-induced immunity

PROJECT_TITLE: IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

PROJECT_TERMS: 2019-nCoV;Animals;co-infection;Goals;Human;Immune;Immune response;Immune Targeting;Immunologics;improved;multidisciplinary;Mycobacterium tuberculosis;Natural Immunity;nonhuman primate;Participant;programs;Research Personnel;response;Tissues;Tuberculosis;Tuberculosis Vaccines;vaccine development;vaccine strategy

PROJECT_TITLE: Immune Mechanisms of Protection Against Mycobacterium Tuberculosis Center (IMPAC-TB)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Vaccine Related

PROJECT_TERMS: 2019-nCoV;Animal Model;Animals;co-infection;cohort;Disease;Goals;HIV;Human;Immune;Immune response;Immune Targeting;Immunologics;improved;Infection;latent infection;multidisciplinary;Mycobacterium tuberculosis;Natural Immunity;nonhuman primate;Participant;prevent;programs;Research Personnel;response;Tissues;Tuberculosis;Tuberculosis Vaccines;vaccination against tuberculosis;vaccine candidate;vaccine efficacy;vaccine strategy


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Valley Fever

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PI_NAMEs: GAGE, KASIA  (contact)

PROJECT_TERMS: Basic Science;Binding;Blastomyces;Coccidioides immitis;Coccidioides posadasii;Communities;Computer software;Cryptococcus neoformans;Data;Databases;Diagnostic;Epitopes;fungus;Histoplasma capsulatum;Human;Immune;immunogenicity;In Vitro;Mediating;multidisciplinary;Pathogenesis;Research;Resources;Role;Support Contracts;T-Lymphocyte;T-Lymphocyte Epitopes;tool;Validation;validation studies

PROJECT_TITLE: Large Scale T Cell Epitope Discovery


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Childhood Obesity;Diabetes;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PI_NAMEs: HUGHES, BRENNA  (contact)

PROJECT_TERMS: Address;Adolescent Behavior;adolescent health;African American;African American population;African American Women;age acceleration;Aging;Anthropometry;arterial stiffness;Behavioral;behavioral outcome;Behavioral Sciences;Biochemical;Bioinformatics;Biological Process;Biometry;Birth;Black American;Blood Pressure;Body fat;Body mass index;cardiovascular disorder risk;Characteristics;Childhood;Chronic Disease;Clinical;cohort;Cohort Studies;Common Data Element;Complications of Diabetes Mellitus;Contractor;Data Collection;delivery complications;design;Development;Diagnosis;Disease;disorder risk;early life exposure;early pregnancy;Enrollment;Epidemiology;Epigenetic Process;father role;Fetal Development;Fetal Growth;Fetal health;Fetal Mortality Statistics;First Pregnancy Trimester;Gene Expression;Genetic;genomic locus;Gestational Diabetes;Glucose;Glycosylated hemoglobin A;Goals;Health;Human;Individual;Intramural Research;Link;male;Measures;member;Mission;National Institute of Child Health and Human Development;Neonatal;neonatal health;neonatal morbidity;Neonatal Mortality;neonatal outcome;neonate;Newborn Infant;Patient Self-Report;Placenta;population health;Pregnancy;pregnancy health;Pregnant Women;prenatal exposure;Preparation;Procedures;programs;prospective;Public Health;Randomized;Randomized, Controlled Trials;recruit;Reproduction;Research;Research Methodology;Risk Factors;Sampling;Seminal fluid;Site;Social Sciences;Testing;Time;Training;ultrasound;Variant;waist circumference;Woman;women's diagnosis

PROJECT_TITLE: START UP, PREPARATION, AND TEST ENROLLMENT FOR THE STUDY OF PREGNANCY AND NEONATAL HEALTH (SPAN)


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Contraception/Reproduction;Endometriosis;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: MENLO PARK

ORG_NAME: SRI INTERNATIONAL

ORG_STATE: CA

PI_NAMEs: GONG, LEYI  (contact)

PROJECT_TERMS: Adenomyosis;Archives;autism spectrum disorder;Bacterial Infections;Biological;Chemicals;Contraceptive Agents;Contraceptive methods;Data;Databases;Down's Syndrome;drug development;Dysmenorrhea;endometriosis;Equipment;Equipment and supply inventories;Fetal Growth Retardation;Fibroid Tumor;Gestational Diabetes;Gynecologic;Health;improved;in vivo evaluation;Infertility;Inflammation;Lactation;Maintenance;mastitis;microbiome;Mission;Muscular Dystrophies;National Institute of Child Health and Human Development;Natural Products;Necrotizing Enterocolitis;novel;Pelvic Pain;Perinatal;Pituitary-dependent Cushing's disease;Placenta;Polycystic Ovary Syndrome;Polymers;Pre-Eclampsia;Premature Birth;Production;Reproductive Health;Research;Rett Syndrome;Role;screening;Sepsis;small molecule;United States National Institutes of Health;Virus Diseases;Vulvodynia

PROJECT_TITLE: CHEMICAL SCREENING AND OPTIMIZATION FACILITY - MANAGEMENT, ADMINISTRATION AND DATABASE CORE FUNCTION ACTIVITIES


ADMINISTERING_IC: OH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

PI_NAMEs: YOST, MICHAEL G (contact)

PROJECT_TITLE: Pacific Northwest Agricultural Safety and Health Center


ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PI_NAMEs: SANDERSON, WAYNE T. (contact)

PROJECT_TITLE: Southeast Center for Agricultural Health and Injury Prevention


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases;Women's Health Research

ORG_STATE: VA

PHR: PROJECT NARRATIVE Acute myeloid leukemia (AML) remains an incurable malignancy despite the recent approval of molecularly targeted therapies. The Bcl-2 antagonist/BH3 mimetic, venetoclax, is routinely used in combination with chemotherapy or hypomethylating agents in newly diagnosed AML, but incomplete responses demonstrate a need for novel treatment modalities to improve venetoclax efficacy. The F99 phase of this proposal investigates the mechanisms of synergy and in vivo efficacy of co-inhibiting the pro-survival sphingolipid enzyme, acid ceramidase, and Bcl-2 in AML, while the K00 phase leverages CRISPR screening and dynamic BH3 profiling to develop rational sphingolipid-based drug combinations in breast cancer.

PI_NAMEs: UNG, JOHNSON  (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Academia;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Affect;analog;antagonist;anti-cancer research;Apoptosis;Apoptotic;bcl-xlong protein;BCL2 gene;BCL2L1 gene;Bioinformatics;biological adaptation to stress;Biological Assay;Biological Markers;biomarker identification;Bone marrow failure;Breast Cancer Model;Breast Cancer Treatment;Cancer Research Project;cancer therapy;career;Cell Death;Cell Line;Cell Membrane Permeability;Ceramides;chemotherapy;Clinical;combinatorial;Combined Modality Therapy;CRISPR screen;CRISPR/Cas technology;Data;Data Analyses;design;Drug Combinations;drug sensitivity;Electron Microscopy;Engraftment;Enzymes;Equilibrium;Family;FDA approved;galactosylgalactosylglucosylceramidase;Genetic;genomic data;Goals;Grant;Human;Hydrolase;Impairment;improved;In Vitro;in vivo;inhibitor;Isopropyl Thiogalactoside;knock-down;Knock-out;Learning;leukemia;leukemia treatment;Link;Lipids;Malignant Breast Neoplasm;Malignant Neoplasms;MCL1 gene;Mediating;member;Mentors;Metabolism;Methods;mimetics;Mitochondria;Modality;molecular targeted therapies;Mus;Myelogenous;Myeloproliferative disease;N-caproylsphingosine;nanoliposome;Newly Diagnosed;novel;Outcome;Outer Mitochondrial Membrane;overexpression;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Postdoctoral Fellow;pre-doctoral;precision medicine;preclinical efficacy;Productivity;prognostic value;programs;protein expression;Protein Family;Proteins;Relapse;Research;Research Personnel;Research Project Grants;Resistance;Respiration;respiratory;response;Role;Sampling;Series;Signal Transduction;skills;Solid Neoplasm;Sphingolipids;sphingosine 1-phosphate;synergism;Testing;Therapeutic;therapeutic target;Training;transcriptome sequencing;transcriptomics;Treatment Efficacy;treatment strategy;triple-negative invasive breast carcinoma;Up-Regulation;vector;whole genome;Work

PROJECT_TITLE: Mechanisms and In Vivo Efficacy of Synergistic Acid Ceramidase and Bcl-2 Inhibition in Acute Myeloid Leukemia


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: CHICAGO

ORG_NAME: NORTHEASTERN ILLINOIS UNIVERSITY

ORG_STATE: IL

PI_NAMEs: CIECIERSKI, CHRISTINA  (contact)

PROGRAM_OFFICER_NAME: SAN MIGUEL-MAJORS, SANDRA L

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PI_NAMEs: AHLUWALIA, JASJIT SINGH (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: addiction;Address;Advisory Committees;alcohol abuse therapy;alcohol and other drug;Alcohols;ARHGEF5 gene;biopsychosocial;career;career development;Centers of Research Excellence;Chronic Disease;Clinical;Communities;Complement;design;Development;Development Plans;Disease;disorder risk;Doctor of Philosophy;early-career faculty;Educational workshop;Effectiveness;Ensure;ethnic minority;Evaluation;experience;Faculty;Feedback;Funding;Goals;Grant;Health;health disparity;high risk population;Hospitals;improved;Individual;innovation;Institution;interest;International;Investments;Journals;Laboratories;Leadership;Link;member;Mentors;Minnesota;minority communities;minority health;minority health disparity;Monitor;multidisciplinary;National Institute on Alcohol Abuse and Alcoholism;National Institute on Minority Health and Health Disparities;Nicotine Dependence;organizational structure;Phase;Physicians;Pilot Projects;Postdoctoral Fellow;Principal Investigator;programs;Psychologist;racial minority;recruit;Research;Research Ethics;Research Personnel;Research Project Grants;Research Training;Resources;Risk;Science;Scientist;Secure;senior faculty;Series;substance use;success;Training;Training Programs;Underrepresented Populations;underserved community;Underserved Population;United States National Institutes of Health;Universities;Work;Writing


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: No PHR

PI_NAMEs: ABRAMOV, DMITRY ;ANTON-CULVER, HODA A (contact);CHOW, EMILIE ;LEE, SCOTT ;LEVERONI-CALVI, MATTEO ;PARK, HANNAH LUI;REIKES, ANDREW ;STAMOS, MICHAEL J;YOUSSEF, FADY A;ZHENG, KAI ;ZIOGAS, ARGYRIOS

PROGRAM_OFFICER_NAME: PRABHUDAS, IRENE

PROJECT_TITLE: All of Us Southern California Consortium (AoUSCC): Engagement, Enrollment, and Retention of Diverse Populations


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD)

ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Narrative Noncoding structural variants (SVs) represent a largely undefined component of the genetic architecture of developmental disorders (DDs). There are a handful of examples of noncoding SVs associated with long-range positional effects (LRPEs) that result in DDs, but the characterization of LRPEs and the delineation of their underlying mechanism has not been systematically investigated. The proposed studies will investigate the prevalence and molecular mechanisms contributing to pathogenic LRPEs in DDs by performing SV association analysis with large case control cohorts as well as paired transcriptomic and chromatin profiling in individuals with large chromosomal abnormalities to identify features predictive of LRPEs across the genome.

PI_NAMEs: LOWTHER, CHELSEA  (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: 3-Dimensional;Address;Advisory Committees;Appointment;Architecture;Balanced Chromosomal Translocation;Base Pairing;career;case control;Catalogs;Cell Line;Characteristics;Chromatin;Chromatin Structure;Chromosome abnormality;cohort;Collaborations;Collection;college;comparison control;Complex;Cytogenetics;Data;Data Set;developmental disease;Diagnosis;Diagnostic;diagnostic value;Disease;disorder risk;DNA Sequence Alteration;Evolution;exome sequencing;Fellowship;fetal;functional genomics;gene discovery;Gene Expression;Gene Targeting;General Hospitals;Genes;genetic architecture;Genetic Variation;Genome;genome sequencing;genome-wide;Genomic approach;Genomic medicine;Goals;Human;human disease;Human Genetics;improved;Individual;International;Learning;malformation;Massachusetts;medical schools;Medicine;Mentors;Mentorship;Methods;mid-career faculty;model building;Modeling;Molecular;Molecular Conformation;Molecular Genetics;Mutation;neuropsychiatry;novel;Nuclear;Pathogenicity;Pattern;Perinatal mortality demographics;population based;post-doctoral training;Postdoctoral Fellow;postnatal period;prenatal;Prevalence;programs;Protein Truncation;Regulation;Research;Research Personnel;Risk;RNA analysis;Sampling;Statistical Methods;Statistical Models;Structure;Technology;Training;Training Programs;transcriptome sequencing;transcriptomics;Untranslated RNA;Variant;whole genome;Work

PROJECT_TITLE: Disruption of three-dimensional genome organization as a noncoding mechanism of disease in human developmental disorders

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PHR: Project Narrative De no!ID haplotype-resolved genome assembly is the most comprehensive solution to understand genomic sequences. This proposal aims to develop cost-effective computational methods for high-quality haplotype-resolved assemblies by utilizing multiple sequencing technologies. The new assembly algorijhms in this proposal not only could be used by large-scale sequencing consortiums such as the Human Pangenome Reference Consortium (HPRC) and the Genome in a Bottle (GIAB), but also could pave the way to personal genome assembly for genomic research and clinical applications.

PI_NAMEs: CHENG, HAOYU  (contact)

PROGRAM_OFFICER_NAME: WETTERSTRAND, KRIS A

PROJECT_TITLE: Robust and cost-effective computational methods for haplotype-resolved genome assemblies


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Fragile X syndrome (FXS), the most common inherited form of intellectual disability and a leading genetic cause of autism spectrum disorders (ASD), is caused by the loss of functional fragile X mental retardation protein (FMRP). Recent technological development of 2D and 3D culture derived from human iPSCs provides a new platform to investigate human brain development in a dish, otherwise inaccessible to experimentation. This multi-project Center aims to establish a framework to understand the FMRP-mediated regulation of human brain development at molecular, cellular and system circuitry levels that will enable the development of therapeutic approaches to treat FXS.

PI_NAMEs: JIN, PENG  (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: 3-Dimensional;5' Untranslated Regions;Adherent Culture;Animal Model;Area;autism spectrum disorder;Behavioral;Binding;Biological Models;Brain;cell type;Cells;CGG repeat;Clinical Trials;crosslinking and immunoprecipitation sequencing;Data;Development;Disease;Dissection;Drosophila genus;drug discovery;Drug Modulation;Electrophysiology (science);FMR1 gene;follow-up;Fragile X Syndrome;Functional disorder;functional loss;GABA Receptor;Gene Expression Regulation;Genetic;genome editing;genome-wide;Goals;Human;Human Development;human disease;human induced pluripotent stem cells;human model;Hypermethylation;In Vitro;in vivo;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Inherited;Intellectual functioning disability;Knowledge;Learning;Link;Mediating;messenger ribonucleoprotein;Messenger RNA;Metabotropic Glutamate Receptors;Modeling;Molecular;mouse model;Mus;neural;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Organoids;Pharmaceutical Preparations;Polyribosomes;preclinical study;promoter;Protein Biosynthesis;Regulation;Research;Research Personnel;RNA;RNA-Binding Proteins;Rodent;Role;screening;Signal Transduction;single cell genomics;single-cell RNA sequencing;small molecule;stem cell model;stem cells;Synapses;synaptogenesis;synergism;System;Technical Expertise;Technology;technology development;Testing;Therapeutic;therapeutic development;three-dimensional modeling;tool;transcriptome;transcriptomics;Translational Regulation;Translations;translatome;Validation

PROJECT_TITLE: FMRP-mediated Regulation in Human Brain Development and Therapeutic Advancement


NIH_SPENDING_CATS: Brain Disorders;Fragile X Syndrome;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: BASSELL, GARY J (contact)

PROJECT_TERMS: 3-Dimensional;Address;Adult;Animal Model;Automobile Driving;Behavior;Binding;Brain;Cell Proliferation;cell type;Cells;Clinical Trials;Collaborations;comparative;Coupled;crosslinking and immunoprecipitation sequencing;Data;Defect;Development;Disease;Down-Regulation;drug efficacy;effective therapy;Embryo;experimental study;Failure;fetal;FMR1 gene;Fragile X Syndrome;Hippocampus;Human;human induced pluripotent stem cells;Impairment;induced pluripotent stem cell;insight;Joints;Lentivirus;Mediating;Messenger RNA;migration;Modeling;Molecular;Molecular Target;monolayer;Morphology;mouse model;mRNA Translation;Mus;neural;neural model;neurodevelopment;neurogenesis;neuron development;Neuronal Differentiation;neuronal excitability;Neurons;neurophysiology;neurotransmission;novel;Nuclear Pore Complex;Organoids;Outcome;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Phenotype;Physiological;preclinical study;primary endpoint;Proliferating;Protein Biosynthesis;Proteins;Regulation;Reporting;Retinoic Acid-Binding Proteins;ribosome profiling;RNA;Role;Signal Transduction;single-cell RNA sequencing;small molecule;Synapses;Synaptic plasticity;synergism;System;Testing;Therapeutic;Therapeutic Intervention;three-dimensional modeling;Tissues;tool development;transcriptome sequencing;translating ribosome affinity purification and RNA-sequencing;Translations;translatome;Work

PROJECT_TITLE: Project 1


ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: The overarching goal of our Center proposal entitled “Translational Medicine and Mechanistic Studies of Brain Neurophysiology in Fragile X Syndrome” is to utilize highly interrelated research strategies with two primary aims, advancing translational medicine approaches (biomarker development, drug challenge studies, resolving illness heterogeneity) and expanding the mechanistic understanding of Fragile X syndrome (FXS) biology. The goal of this work is to foster the development of new, more effective therapies. We propose to pursue these aims through the establishment of integrated, interdependent research programs from patient-centered research to in vivo animal experiments to cellular sub-type specific and molecular models.

PI_NAMEs: ERICKSON, CRAIG  (contact)

PROJECT_TERMS: Address;Animal Experiments;Animal Model;Back;Behavior;Behavioral;bench to bedside;Biological Markers;Biology;biomarker development;Brain;brain dysfunction;Cholecystokinin;Clinical;Clinical Research;Clinical Sciences;Clinical Trials;clinically relevant;Cognition;Collaborations;Data;design;Development;Disease;drug development;Drug Monitoring;effective therapy;Electroencephalography;Electrophysiology (science);endocannabinoid signaling;Endocannabinoids;endogenous cannabinoid system;Ensure;Environment;experience;Failure;FMR1 gene;Fostering;Fragile X Syndrome;Future;Gene Proteins;gene therapy;Glutamates;Goals;Heterogeneity;Human;human study;improved;in vivo;individualized medicine;insight;interest;Interneurons;Investigation;Knowledge;Link;Measures;Methodology;Mission;Modeling;Molecular;Molecular Analysis;molecular modeling;multi-electrode arrays;multidisciplinary;Mus;Neocortex;network models;neural circuit;neurobehavioral;Neurobiology;Neurons;neurophysiology;Neurosciences Research;neurotransmission;novel;novel therapeutics;Patient Monitoring;patient oriented;patient stratification;Patients;personalized medicine;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phenotype;Physiology;pre-clinical;pre-clinical research;preclinical study;predictive marker;Preparation;Principal Investigator;programs;protein expression;receptor;Research;response;Risk;Role;Science;Shapes;Slice;small molecule;Speed;Stimulus;success;Surface;Technology;Testing;Therapeutic Effect;therapy development;Time;translational medicine;translational potential;Translations;Work

PROJECT_TITLE: Translational medicine and mechanistic studies of brain neurophysiology in Fragile X Syndrome


NIH_SPENDING_CATS: Brain Disorders;Cannabinoid Research;Endocannabinoid System Research;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Rare Diseases

PI_NAMEs: HUBER, KIMBERLY M. (contact)

PROJECT_TERMS: Acute;Area;base;Behavior;behavioral phenotyping;Biochemical;Brain;cell type;Cholecystokinin;Clinical;CNR1 gene;Collaborations;Contralateral;Coupling;Cre driver;Data;Defect;Electroencephalography;Endocannabinoids;Environment;Excitatory Synapse;experience;experimental study;FMR1 gene;Fragile X Syndrome;Frequencies;Functional disorder;Genetic;genetic manipulation;Glutamates;hippocampal pyramidal neuron;Human;in vivo;inhibitory neuron;Knock-out;Link;loss of function;Measures;Mediating;Methods;Molecular;mouse model;Mus;neocortical;Neurons;neurophysiology;optogenetics;Outcome;Parvalbumins;pharmacologic;Phenotype;Positioning Attribute;postnatal;Process;Proteins;receptor;Regulation;Research Personnel;response;Rest;Ribosomes;RNA;Role;Sensory;sensory cortex;Slice;somatosensory;Somatosensory Cortex;sound;Synapses;targeted treatment;Testing;Thalamic structure;Touch sensation;transcriptome;transcriptome sequencing;Translating;translational medicine;translatome

PROJECT_TITLE: FMRP regulation of local and long-range neocortical circuits in the mouse:  Links with EEG phenotypes


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PI_NAMEs: AYE, PYONE  (contact)

PROJECT_TERMS: Adjuvant;AIDS prevention;AIDS Vaccines;Breeding;Cells;clinical efficacy;CXCL10 gene;CXCR3 gene;cytokine;Development;DNA;Evaluation;evaluation/testing;flexibility;Goals;HIV vaccine;HIV-1 vaccine;Housing;IL6 gene;Immune response;immunogenicity;Maintenance;Modality;Modeling;Mucosal Immune Responses;National Institute of Allergy and Infectious Disease;nonhuman primate;preclinical evaluation;preclinical study;prevent;Prevention Research;Prevention strategy;programs;Proteins;research clinical testing;Research Personnel;Resources;Risk;Testing;United States National Institutes of Health;vaccine efficacy;vaccine evaluation;vaccine platform;Vaccine Research;Vaccines;Virus;Virus Diseases

PROJECT_TITLE: Potent Boosting of Tfh1 Cells to Enhance HIV-1 Vaccine Efficacy


NIH_SPENDING_CATS: Cancer

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PI_NAMEs: GAN, BOYI  (contact)

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TITLE: Ferroptosis resistance as a key driver in acquired radiation resistance


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: CHARLESTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE d Opioid use disorder (OUD) frequently co-occurs with posttraumatic stress disorder (PTSD), and there is an imminent need for the development of effective interventions addressing this severe comorbidity. The proposed study will test the preliminary efficacy of combining medications for OUD with an integrated, trauma-focused, behavioral treatment for co-occurring substance use disorders and PTSD while advancing Dr. Saraiya’s goal to become an independent clinical researcher in the field of opioid research. Findings will demonstrate how a combined treatment approach may reduce opioid use and PTSD symptoms, enhance retention on medications for OUD and in behavioral treatment, and decrease public health care costs among a population in dire need.

PI_NAMEs: SARAIYA, TANYA CHANDRESH (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TITLE: Integrated Treatment for Co-Occurring Opioid Use Disorder and Posttraumatic Stress Disorder

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Telehealth;Women's Health Research

PI_NAMEs: HARVILLE, EMILY WHEELER (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Address;Administrative Supplement;Adoption;Age;Area;Birth;Black race;black women;Blood Pressure;Caring;Client satisfaction;Communities;community collaboration;cost effectiveness;County;Data;Data Collection;design;digital;effectiveness evaluation;effectiveness/implementation hybrid;electronic health record system;Eligibility Determination;empowerment;Ethnic Origin;experience;Focus Groups;geographic disparity;Goals;Health;health care availability;Health Services Accessibility;high risk;Home;Hospitals;implementation barriers;implementation evaluation;implementation intervention;implementation outcomes;Improve Access;improved;Infrastructure;innovation;Internet;Intervention;Interview;Leadership;Louisiana;Manuals;Maternal Health;Maternal Health Services;Medicaid;Modeling;Monitor;mortality risk;Not Hispanic or Latino;obstetric care;obstetric services;Outcome;Patient Outcomes Assessments;Patients;Persons;Phase;Postpartum Period;Poverty;Pregnancy;pregnant;Premature Birth;Procedures;Process;programs;Protocols documentation;Provider;Race;racial disparity;remote health care;Rural;rural area;Sampling;Services;Site;Socioeconomic Status;Specialist;Technology;Testing;tool;Training;Underinsured;Underserved Population;Weight;Woman

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1]


ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PI_NAMEs: CALIFANO, ANDREA  (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: androgen independent prostate cancer;bone;Cell Line;Cells;Characteristics;curative treatments;Dependence;drug mechanism;Drug Modelings;Drug resistance;Drug Targeting;Evolution;Generations;Genetically Engineered Mouse;Goals;Heterogeneity;in vivo;in vivo Model;insight;Malignant neoplasm of prostate;Metastatic Neoplasm to the Bone;Metastatic Prostate Cancer;Modeling;Morbidity - disease rate;mortality;neoplastic cell;Neuroendocrine Prostate Cancer;novel;Organoids;patient derived xenograft model;Pharmaceutical Preparations;Pharmacotherapy;prostate cancer metastasis;resistance mechanism;response;Series;Site;Technology;tumor;Validation

PROJECT_TITLE: Drug Mechanism of Action-based targeting of tumor subpopulations


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: BUENOS AIRES

ORG_COUNTRY: ARGENTINA

ORG_FIPS: AR

ORG_NAME: FACULTAD LATINOAMERICANA DE CIENCIAS SOCIALES

PHR: Project Narrative This program educates researchers and members of research ethics committees from Latin American countries and improves their expertise in research ethics, thereby increasing ethical capabilities in the conduct and review of research. It also provides continuing education in research ethics for former trainees to ensure ongoing sustainability of research ethics in the region.

PI_NAMEs: LUNA, FLORENCIA  (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Active Learning;Address;Advisory Committees;Americas;Area;Argentina;Attention;Awareness;Career Choice;Collaborations;college;community advisory board;Continuing Education;Country;Critical Thinking;Education;Educational Activities;Educational Status;Ensure;Ethical Issues;Ethicists;Ethics;experience;Health;improved;Individual;innovation;Institution;International;Journals;Latin American;learning strategy;Master of Science;Medicine;meetings;member;Mentors;Persons;post-doctoral training;programs;Publishing;Reading;Research;Research Ethics;Research Ethics Committees;Research Personnel;Resources;responsible research conduct;Scientist;skills;Social Sciences;System;systems research;Time;Training;Training Programs;Work;Workload;Writing

PROJECT_TITLE: Training Program in Research Ethics in the Americas