NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Kidney Disease;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Non-Human

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: This proposal examines novel genetic and epigenetic mechanisms that enable immature cells in the embryo to form mature nephrons, the functional filtering units in the kidney. Our long-term goal is to harness these normal mechanisms of organ formation to increase nephron formation in preterm infants and babies born with small kidneys (hypoplasia) due to birth defects. Our studies should also provide insight into regeneration and repair in acquired kidney diseases that cause end stage organ failure in adults.

PI_NAMEs: RAUCHMAN, MICHAEL I (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Area;Back;Binding;Cell Differentiation process;Cell Lineage;Cell Separation;cell type;Cells;Childhood;Chromatin;Chromatin Remodeling Factor;Chronic Kidney Failure;Complement;Complex;conditional mutant;Congenital Abnormality;Cues;Deacetylase;Defect;Development;Disease;Distal;Embryo;end-stage organ failure;Endowment;Enhancers;Epigenetic Process;epigenome editing;Epithelial Cells;Equilibrium;Event;exhaustion;Functional disorder;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene regulatory network;Genes;Genetic;Genome;genome-wide;Genomics;Goals;Henle's loop;Human;Human Development;human disease;Human Genetics;human induced pluripotent stem cells;Hypertension;Impairment;Individual;induced pluripotent stem cell;inhibitor;Injury;insight;Kidney;kidney cell;Kidney Diseases;Kidney Failure;Knock-in Mouse;Knowledge;Life;LoxP-flanked allele;Methods;Modification;Molecular;Mus;mutant;Natural regeneration;nephrogenesis;nephron progenitor;Nephrons;novel;Nucleic Acid Regulatory Sequences;Nucleosomes;Organ;Pattern Formation;Physiological;Play;Polycomb;Population;predictive modeling;Premature Birth;Premature Infant;progenitor;programs;Proliferating;promoter;Proteins;Regulation;Regulatory Element;renal epithelium;Renal function;Renal glomerular disease;repaired;Research;Role;self-renewal;Signal Pathway;Signal Transduction;Sodium Chloride;stem cell differentiation;stem cell fate;stem cell genes;stem cell growth;stem cell proliferation;stem cell self renewal;stem cells;Sucrose;Syndrome;Testing;Time;Tissues;transcription factor;Translating;Tubular formation;Undifferentiated;Water;WNT Signaling Pathway;Work

PROJECT_TITLE: Epigenetic mechanisms of gene regulation in nephron progenitor cell proliferation and differentiation

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Microbiome;Pediatric

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Shortly after birth, newborns are rapidly colonized by a complex and dynamic community of microorganisms. This initial colonization event plays an essential role in healthy development and perturbation to this process can have major consequences later in life. The ecological principles and molecular interactions that regulate succession of the microbial community during early life are not well understood. We will generate a comprehensive spatial map and molecular blueprint of metabolic interactions in the gut microbiota during early life colonization and perturbation to better understand the fundamental principles that mediate formation and maintenance of a stable community. !

PI_NAMEs: ZACKULAR, JOSEPH PAUL (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TITLE: Molecular interactions in the gut microbiota during early life colonization and perturbation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: CHICAGO

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Narrative - Public Health Relevance Statement: Small molecules of medicinal interests generally contain carbon-carbon (C−C) bonds in their skeletons, thus methods that selectively edit specific C−C bonds are highly desirable as syntheses of biologically important compounds could be simplified or streamlined. However, broadly applicable C−C activation approaches remain largely elusive. The outlined proposal exploits several unique modes of transition-metal- mediated C−C bond activation discovered in our laboratory in developing a suite of catalytic methods that are useful for preparing complex molecules.

PI_NAMEs: DONG, GUANGBIN  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Catalytic C−C Activation/Functionalization of Ketones and Amides

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hearing Loss;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: LITTLE ROCK

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PUBLIC HEALTH RELEVANCE School-based health programs provide essential access to preventive services for rural underserved and minority American children, but loss to follow-up and limited numbers of specialists are problematic. This study will prospectively evaluate a new virtual specialty triage model in Alaska schools to reduce loss to follow-up from school hearing screening and improve access to specialty care in rural environments. This telehealth model to address preventable childhood hearing loss could be translated to other rural underserved and minority populations.

PI_NAMEs: EMMETT, SUSAN DAVIS (contact);HIRSCHFELD, MATTHEW J

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: access disparities;Achievement;Acute;Address;Air;Alaska;Alaska Native;Alaska Native population;American;barrier to care;care delivery;Caring;Child;Child Health;childhood hearing loss;Clinic;clinical care;Cluster randomized trial;Collaborations;Communities;community based research;Consolidated Framework for Implementation Research;Consult;COVID-19;current pandemic;Data;design;Development;Diagnosis;Ear;Early treatment;Education;effectiveness testing;Employment Opportunities;experience;Feedback;Focus Groups;follow-up;Funding;Future;geographic barrier;Health;health care availability;health disparity;Health Services;Health Services Accessibility;Health system;Hearing;hearing impairment;hearing screening;High Prevalence;Home;implementation barriers;implementation protocol;implementation science;implementation trial;Improve Access;improved;informant;innovation;Intervention;Interview;Language Development;Lead;Leadership;Letters;medical specialties;minority children;Minority Groups;Modeling;Modification;National Institute on Deafness and Other Communication Disorders;novel;Parents;Pathway interactions;payment;Policies;Policy Analysis;Policy Maker;Population;Prevalence;Prevention;Preventive service;Primary Care;primary outcome;programs;prospective;Protocols documentation;public health relevance;Randomized;Recording of previous events;Research;Rural;rural Alaska;rural area;Rural Community;rural environment;Rural Minority;Rural Population;rural underserved;scale up;School Nursing;School Teachers;Schools;screening;screening program;Services;Social Work;Specialist;success;support network;System;teacher;telehealth;Telemedicine;Testing;Time;Translating;Travel;Triage;tribal health;Tribes;Underserved Population;virtual;Work

PROJECT_TITLE: North STAR Trial: Specialty Telemedicine Access for Referrals in Rural Alaska

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Hematology;Immunotherapy;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: LA JOLLA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Multiple myeloma (MM) is the second most common hematological malignancy. Despite the incorporation of novel agents in the autologous stem cell transplant (ASCT) backbone for MM treatment, MM remains incurable. In this application, we propose to target a novel immune regulatory pathway, the versican (VCAN) pathway, in order to optimize post-ASCT therapy for myeloma, and thus to prevent or delay relapses.

PI_NAMEs: ASIMAKOPOULOS, FOTIOS  (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: ADAMTS;Address;adverse outcome;Amino Acids;analog;Antibodies;Antigen-Presenting Cells;Autologous Stem Cell Transplantation;Avian Leukosis Virus;Binding;Bone Marrow;Bone Marrow Stem Cell Transplantation;Carcinoma;Cell Density;cell growth;Cell secretion;Cells;Coupled;CRISPR/Cas technology;cytokine;Cytometry;Dendritic Cells;design;Distal;Eligibility Determination;Engraftment;Equilibrium;experimental study;extracellular;Extracellular Matrix;FDA approved;FLT3 ligand;Generations;Goals;Hematologic Neoplasms;Hematopoietic Neoplasms;Human;IL17 gene;IL6 gene;Immune;Immunity;Immunologics;Immunomodulators;immunoregulation;Immunotherapy;In Vitro;in vivo;Inferior;Infiltration;inhibitor;Interleukin-10;Investigation;Knowledge;lenalidomide;Lentivirus Vector;Ligands;macromolecule;Macrophage;Maintenance;Mediating;MEKs;Modeling;molecular targeted therapies;Multiple Myeloma;Mutate;Myelogenous;Myeloid Cells;N-terminal;neutralizing antibody;novel;Oral;paracrine;Parents;Pathway interactions;Patients;Physiological;polarized cell;prevent;Process;Protein Isoforms;Proteoglycan;Proteolysis;Regulatory Pathway;Relapse;relapse patients;relapse prevention;Reporting;Resolution;response;Revlimid;Role;Safety;Signal Transduction;single-cell RNA sequencing;Site;standard of care;success;Testing;Thalidomide;Therapeutic;therapeutic target;TLR2 gene;Transcript;Transplantation;transplantation therapy;treatment strategy;tumor;versican;Vertebral column

PROJECT_TITLE: Tumor matrix remodeling in anti-myeloma immunity and immunotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Diabetes;Genetics;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases;Spina Bifida;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Under modern preconceptional care, women with pregestational diabetes are three- to four-times more likely to have a child with birth defect than women without diabetes. Revealing the role of dysregulated RNA methylation in the formation of neural tube defects in diabetic pregnancy will improve our understanding the cause of diabetic embryopathy and provide important insights for the development of novel prevention strategies.

PI_NAMEs: REECE, E. ALBERT (contact);SHEN, WEI-BIN ;YANG, PEIXIN

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Age;American;Animal Model;Antibodies;Apoptosis;Binding;Biological Process;Cell Differentiation process;Cell Polarity;Cell Proliferation;Child;Congenital Abnormality;Defect;Development;Diabetes Mellitus;diabetic;diabetic embryopathy;DNA;Dominant-Negative Mutation;Embryo;embryo culture;Embryonic Development;Epigenetic Process;epitranscriptomics;Exposure to;FOXO3A gene;Functional disorder;Gene Deletion;Gene Expression;Genes;Genetic Recombination;Genetic Transcription;Glucose;Heterozygote;Immunoprecipitation;improved;Incidence;inhibitor;insight;JUN gene;LoxP-flanked allele;MAPK8 gene;maternal diabetes;Mediating;Messenger RNA;Methylation;Methyltransferase;Modernization;Modification;mouse model;Movement;mRNA Expression;Neural Tube Closure;Neural Tube Defects;Neuroepithelial Cells;neuroepithelium;Neurons;novel;offspring;overexpression;Oxidative Stress;Pathogenesis;Pathway interactions;Phosphotransferases;Physiological;planar cell polarity;Preconception Care;Pregnancy in Diabetics;Prevention strategy;receptor;Repression;reproductive;response;RNA;RNA methylation;Role;Severities;Signal Transduction;superoxide dismutase 1;Teratogens;Testing;transcription factor;transcriptome sequencing;transgene expression;Transgenic Model;Transgenic Organisms;Woman

PROJECT_TITLE: Epitranscriptomic Alteration and Planar Cell Polarity Signaling In Diabetic Embroyopathy

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Disadvantage indices—statistical measures to describe the economic, social and health-related vulnerability of residents in a specific geographic area as small as neighborhoods—were used for Covid-19 vaccine allocation planning for the first time in US' history. This is important because policymakers recognized that traditional frameworks can contribute to, and worsen, structural racism and discrimination, and that disadvantage indices offer a way of mitigating or avoiding such an impact. In this study, we will analyze whether and how different types and uses of disadvantage indices reduced structural racism and discrimination in Covid-19 vaccine allocation, and explore how disadvantage indices can be used in other areas of health care to reduce differences in health and life expectancy across racial and ethnic groups that are due to structural racism and discrimination.

PI_NAMEs: SCHMIDT, THOMAS HARALD (contact);YEARBY, RUQAIIJAH

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: access disparities;Address;Adopted;Adoption;Advisory Committees;Area;Award;care outcomes;Censuses;Cessation of life;clinical care;Collaborations;Color;Communicable Diseases;Communication;Communities;community academic partnership;community advisory board;community engagement;Complement;COVID-19;COVID-19 incidence;COVID-19 vaccine;Data;deprivation;design;Disadvantaged;Discrimination;disorder control;Disparity population;disparity reduction;Economics;Education;emergency settings;Emergency Situation;Engineering;Equity;Ethics;Ethnic Origin;Ethnic Population;Evaluation;Exercise;experimental study;Face;future pandemic;Geographic Locations;Goals;Health;health care availability;health care disparity;health difference;health equity;health equity promotion;health outcome disparity;Health Services Research;Health system;Healthcare;Hospitalization;Hospitals;Housing;improved;Incidence;Income;indexing;innovation;Interview;Journals;Knowledge;Laws;Life Expectancy;Literature;Measures;Medicine;Methods;minority health;Modeling;neighborhood disadvantage;Neighborhoods;novel;Outcome;outreach;pandemic disease;people of color;Persons;Play;Policy Maker;predictive modeling;preference;Psychology;Public Health;Qualifying;Qualitative Methods;Race;racial population;racism;Recommendation;Recording of previous events;Research;Resources;Review Literature;risk mitigation;Role;SARS-CoV-2 exposure;Shapes;Site;social;social vulnerability;Structural Racism;Surveys;symposium;System;Time;tool;United States National Academy of Sciences;US State;Vaccination;vaccine distribution;Vaccines;Work

PROJECT_TITLE: Using Disadvantage Indices to Address Structural Racism and Discrimination in Pandemic Vaccine Allocation and Beyond: Defining the Shape of a Novel Paradigm to Promote Health Equity


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative. We propose to use a combination of large-sample, lifespan functional magnetic resonance imaging (fMRI) data from the Human Connectome Project and advanced statistical modeling to provide (1) optimized methods for estimating the hemodynamic response function (HRF), (2) a large-sample HRF atlas capturing variation across the lifespan, and (3) methods and results estimating a neural connectome after taking the HRF into account. Successful completion of the project will provide more accurate and precise estimates of task-related fMRI activity and brain connectivity in studies of mental health, healthy and pathological aging, substance use, and beyond.

PI_NAMEs: LINDQUIST, MARTIN  (contact);WAGER, TOR D.

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Accounting;Address;Affect;Affective;Age;age difference;aged;Aging;aging related disease;Anxiety;Area;Atlases;Biophysics;Blood Vessels;Body mass index;Brain;Brain region;cerebral hemodynamics;Characteristics;Clinical;Clinical Research;Code;Cognition;Cognitive;cognitive function;cognitive neuroscience;Communities;Complex;Computer software;connectome;connectome data;Coupling;Data;Data Set;depressed patient;Development;Disease;Ecosystem;Estimation Techniques;Functional Magnetic Resonance Imaging;Future;Grant;healthy aging;hemodynamics;high body mass index;Human;human data;Image;Individual;individual variation;interest;Knowledge;life span;Link;low socioeconomic status;Maps;Measurable;Measures;memory retrieval;Mental Depression;Mental disorders;mental function;Mental Health;Mental Processes;Methods;Modeling;Moods;Morphologic artifacts;neural;neuroimaging;Neurosciences;neurovascular;neurovascular coupling;next generation;novel;Paper;Parameter Estimation;Participant;pathological aging;Patients;Persons;Phenotype;Population;population stratification;Post-Traumatic Stress Disorders;Process;Proxy;regional difference;Reproducibility;Research;response;Rest;Sampling;secondary analysis;Series;sex;Shapes;Signal Transduction;Socioeconomic Status;spatiotemporal;Statistical Models;statistics;Structure;Substance abuse problem;substance misuse;substance use;Symptoms;Techniques;Testing;Time;Variant;virtual;Work

PROJECT_TITLE: Personalized spatiotemporal hemodynamic response models for functional magnetic resonance imaging

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The goal of the University of Michigan Kidney, Urology and Hematology Research Training Network is to establish an infrastructure to enable the recruitment and training of predoctoral and postdoctoral trainees. The Program will provide trainees with the skills necessary to pursue careers in research so that they can contribute to the development of advances in the prevention, diagnosis, and treatment of KUH diseases. This training program fills a critical need to increase the number of future leaders in KUH research.

PI_NAMEs: KHORIATY, RAMI ;PENNATHUR, SUBRAMANIAM  (contact);SARMA, ARUNA V

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Advanced Development;Area;Award;base;Basic Science;Bioinformatics;Biological;career;career development;career networking;Clinical Research;Communication;Community Outreach;design;Development;Diagnosis;Disease;diversity and equity;Doctor of Philosophy;Educational Curriculum;Ensure;Equity;equity, diversity, and inclusion;experience;Faculty;faculty mentor;Fostering;Functional disorder;Future;Goals;Grant;Health;Health Care Research;Health Services Research;Hematology;high school;improved;Individual;Infrastructure;Institution;Interdisciplinary Study;interest;Intervention;investigator training;Kidney;Leadership;Learning;member;Mentors;Michigan;next generation;novel therapeutics;Ohio;peer;peer coaching;Physicians;Physiology;Postdoctoral Fellow;pre-doctoral;Prevention;Process;programs;recruit;Research;Research Design;Research Training;Resources;Scientist;Services;skills;Statistical Data Interpretation;Structure;Students;success;System;TNFSF15 gene;Training;Training Programs;Translational Research;undergraduate student;United States;United States National Institutes of Health;Universities;Urology;Writing


NIH_SPENDING_CATS: Hematology;Kidney Disease

PI_NAMEs: PENNATHUR, SUBRAMANIAM  (contact)

PROJECT_TERMS: Advisory Committees;Appropriateness Review;bench to bedside;Clinical;Clinical and Translational Science Awards;Collaborations;Collection;Communication;Consultations;Cost Sharing;Decision Making;design;Development;Education;Effectiveness;Ensure;equity, diversity, and inclusion;Evaluation;Expenditure;Faculty;faculty mentor;Feedback;Funding;Goals;Health;Hematology;improved;Infrastructure;Institution;interdisciplinary approach;Kidney;Leadership;member;Mentors;Michigan;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;operation;outreach;Principal Investigator;Process;Productivity;programs;prospective;recruit;Reporting;Research;Research Training;Resource Allocation;Resources;response;Self-Examination;Services;Site;Structure;Surveys;TNFSF15 gene;Training;Training Programs;Translational Research;Translations;United States National Institutes of Health;Universities;University adminstration;Update;Urology;user-friendly;web site;working group

PROJECT_TITLE: Admin Core


PI_NAMEs: SARMA, ARUNA V (contact)

PROJECT_TERMS: Academy;Awareness;bench to bedside;career;career development;career networking;career preparation;Communication;design;Development;Educational Curriculum;Educational process of instructing;Educational workshop;Equity;equity, diversity, and inclusion;Faculty;Goals;Hematology;improved;Kidney;Leadership;Learning;medical specialties;Mentors;Mentorship;Michigan;next generation;Oral;programs;Reproducibility;Research;Research Personnel;Research Training;responsible research conduct;Science;skills;Technical Expertise;Training;Training Activity;Universities;Urology;Writing

PROJECT_TITLE: Professional Development Core


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Clinical Research;Lung;Rare Diseases

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: SAINT LOUIS UNIVERSITY

PHR: The proposed studies will demonstrate a shared mechanism for halogen gas toxicity mediated by 2-halofatty acid-elicited NET formation. Demonstrating this pathway for both Cl2 and Br2 exposures may lead to the future development of a common therapeutic countermeasure.

PI_NAMEs: FORD, DAVID A. (contact);PATEL, RAKESH P.

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Accidents;Acids;Acute;Acute Lung Injury;Aldehydes;Animals;Blood Coagulation Disorders;Blood Vessels;Bromine;C57BL/6 Mouse;Cardiopulmonary;Caring;Cells;chemical countermeasure;Chemical Warfare;Chemical Warfare Agents;Chemicals;Chemistry;Chlorine;chlorine gas;Circulation;common treatment;cytokine;Data;Development;Disinfection;Dose;Dryness;Endowment;experimental study;Exposure to;extracellular;Failure;Female;Functional disorder;Future;Gases;Goals;Halogens;Human;in vivo;Incubated;indexing;Industrial Accidents;Industrialization;Injury;Lethal Dose 50;Lipids;Lung;lung injury;Maintenance;male;manufacture;manufacturing process;Measures;Mediating;Mediator;Modeling;Morbidity - disease rate;mortality;Mus;neutrophil;Organ;Organ failure;organ injury;Pathway interactions;Pharmacologic Substance;Phospholipids;Plasma;Plasmalogens;Production;programs;Property;Proteins;Proteome;Public Health;Rattus;Regimen;Research;Role;Sprague-Dawley Rats;Swimming Pools;Testing;Therapeutic;therapeutic target;Toxic effect;toxicant;Training;Water;water treatment;Weight

PROJECT_TITLE: Halolipid-Neutrophil Extracellular Trap Axis in Halogen Lung Injury


NIH_SPENDING_CATS: Hematology;Kidney Disease;Pediatric

PI_NAMEs: MARGOLIS, BENJAMIN L (contact)

PROJECT_TERMS: Advocacy;Ally;Clinical;Collaborations;college;Communication;Communities;Community Outreach;Coupled;Diagnostic;disadvantaged student;Discipline;Discipline of Nursing;Engineering;experience;Exposure to;Faculty;Fostering;Funding;Goals;Grant;Hematology;improved;Infrastructure;Institution;interest;Kidney;Learning;Medical;Medical Students;meetings;Mentors;Michigan;next generation;Ohio;Online Systems;outreach;Patients;peer;Persons;Productivity;programs;Research;Research Personnel;Research Training;Resources;Schools;Scientist;screening program;Sister;social media;Structure;Students;summer research;TNFSF15 gene;Training;training opportunity;Training Programs;Training Support;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Students;Underserved Population;Universities;university student;Urologic Surgical Procedures;Urology;virtual

PROJECT_TITLE: Network Core


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence

ORG_CITY: TUCSON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project narrative Arms races with viruses have shaped human genomic adaptation, not only in immune genes, but also across the entire human genome. Over the coming years, my lab will exploit host genomic adaptation to detect, date, and functionally characterize ancient viral epidemics that plagued ancestral human populations. Because past viral threats are more likely to become threats again in the future, ancient epidemics will provide a better assessment of the viruses with the potential to cause future epidemics.

PI_NAMEs: ENARD, DAVID  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: arms race;Automobile Driving;Bayesian Analysis;Complex;COVID-19 pandemic;deep learning;Development;Epidemic;Event;Evolution;Future;future epidemic;future pandemic;Genes;Genetic Predisposition to Disease;Genetic Recombination;Genomics;Graph;Human;Human Genome;Immune;Immune system;Knowledge;Left;lens;Link;Machine Learning;Mutation;novel strategies;pandemic potential;pathogen;Population;reconstruction;Shapes;Signal Transduction;Testing;Time;tool;Viral;viral epidemic;Virus;Work

PROJECT_TITLE: Ancient viral threats through the lens of adaptation in human genomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Dementia;Depression;Mental Health;Neurodegenerative;Neurosciences;Opioids;Pain Research

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative There is an increasing number of patients with Alzheimer’s disease and related dementia (ADRD) using prescription opioids chronically or concurrently with other central nervous system medications, but evidence on the clinical and safety outcomes of these common opioid prescribing practices in this fast-growing, vulnerable population is lacking. There is also a poor understanding of the role of opioids on cognition in older adults with chronic pain. The proposed research, which is responsive to the priorities of the National Plan to Address Alzheimer’s Disease, will contribute to informing optimal use and safe opioid prescribing for chronic pain that is commonly comorbid in patients with ADRD.

PI_NAMEs: WEI, YU-JUNG “JENNY”  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;anti-depressive agents;Anticonvulsants;Caring;Central Nervous System;Central Nervous System Agents;Central Nervous System Depressants;Chronic;chronic pain;chronic pain management;Classification;Clinical;clinical effect;Clinical Trials;Cognition;cognitive function;cognitive testing;cohort;Communities;Community Surveys;comorbidity;Complex;Cytochrome P450;Data;Data Set;Dementia;dementia risk;Diagnosis;Dose;Drug Kinetics;Enzymes;fall injury;falls;follow-up;Goals;Guidelines;Health;high risk;Hospitalization;Impaired cognition;improved;inhibitor;Knowledge;Link;Literature;longitudinal dataset;Longitudinal Studies;Longitudinal Surveys;Medicare;Medicare claim;Medication Systems;Memory;Mental Depression;Mental Health;Metabolic Pathway;Metabolism;neuropsychiatric symptom;non-cancer chronic pain;non-demented;Nursing Assessment;Nursing Homes;older adult;Opioid;opioid therapy;opioid use;opioid use disorder;Outcome;Outcome Measure;Overdose;Pain;Pain intensity;Pain management;pain symptom;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;physical conditioning;Physical Function;Population;Population Study;prescription opioid;primary outcome;Probability;Property;Quality of Care;Recommendation;Reporting;Research;Retirement;Role;Safety;safety outcomes;Sampling;secondary outcome;Statistical Data Interpretation;Surveys;Time;Vulnerable Populations;Work

PROJECT_TITLE: Opioid Prescribing Practices and Health Outcomes among Patients with Alzheimer's Disease and Related Dementia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-L(90)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Prevention;Substance Misuse

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE Opioid use and addiction among chronic pain population is a serious public health concern with significant economic and social burden. The current proposal addresses a critical gap in our knowledge relating to pain avoidance behavior which when maladaptive in the chronic pain state is a major driver for opioid abuse. Knowledge about behavioral and neurophysiological constructs of pain avoidance behavior in chronic pain patients will help identify and treat those at risk for opioid use disorder, and develop long-term non-addictive therapeutic interventions.

PI_NAMEs: GOPALAKRISHNAN, RAGHAVAN  (contact)

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: Acute Pain;addiction;Address;Affect;Age;American;Anterior;Area;Association Learning;avoidance behavior;Avoidance Learning;Basic Science;Behavior;Behavioral;biomarker identification;Biomedical Engineering;Brain;Brain Mapping;chronic back pain;chronic pain;chronic pain patient;Clinical Research;Clinical Trials;Code;Complex Regional Pain Syndromes;computational neuroscience;Computer Models;cooking;Coupling;Cues;Data;Data Analyses;Data Collection;Development;Disease Marker;disorder risk;Economic Burden;Economics;Educational process of instructing;Electrophysiology (science);Equipment and supply inventories;Event;expectation;experience;Extinction;Fostering;Frequencies;Fright;Future;Goals;healing;Impairment;improved;interest;Intervention;Investigation;Knowledge;Leadership;Learning;Life;Magnetoencephalography;maladaptive behavior;Measures;Mediation;Mediator;Mental disorders;Methods;Modeling;multidisciplinary;multimodality;neural;Neurons;neurophysiology;Neurosciences;non-opioid analgesic;novel;Opiate Addiction;opioid abuse;opioid use;opioid use disorder;Outcome;Pain;Pain management;pain model;pain outcome;pain patient;pain perception;Pathway interactions;Patients;Periodicity;Personality Traits;Persons;Placebo Effect;Population;post stroke pain;Prefrontal Cortex;prevent;Prevention;Prevention strategy;Process;Psychological reinforcement;Psychology;Psychophysiology;Public Health;public health relevance;Recording of previous events;Recovery;Research;Resolution;Resources;response;response to injury;Rewards;Risk;Risk Factors;Role;Science;Self Direction;Sensory;signal processing;Signal Transduction;social;Societies;Temperament;Therapeutic Intervention;tool;Training;training opportunity;trait;treatment strategy;Update;Walking

PROJECT_TITLE: Pain avoidance behavior and its relation to risk for opioid use in chronic pain patients

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


NIH_SPENDING_CATS: Complementary and Integrative Health;Natural Products

ORG_CITY: TUSCALOOSA

ORG_NAME: UNIVERSITY OF ALABAMA IN TUSCALOOSA

ORG_STATE: AL

PHR: Project Narrative Natural products play a key role in drug discovery and development. I propose to develop a workflow that discovers novel bioactive natural products and unique biosynthetic enzymes that will significantly advance medicine to improve human health.

PI_NAMEs: HIGGINS, MELANIE ANN (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Anabolism;bioactive natural products;Biochemical Reaction;Biological Availability;Complex;drug development;drug discovery;Enzymatic Biochemistry;Enzymes;Family;Gene Cluster;Genes;genetic information;Genome;glycosylation;glycosyltransferase;guided inquiry;Health;Human;hygromycin A;improved;Lead;Link;Medicine;Methods;Mining;Modification;Natural product discovery;Natural Products;novel;Pathway interactions;Play;programs;Reaction;Research;Role;scaffold;small molecule;Structure;tool

PROJECT_TITLE: Investigating biosynthetic enzymes to enhance natural product discovery


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Drug Abuse (NIDA only);Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Substance Misuse

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE We anticipate that the research proposed will provide novel and critically important tools in artificial intelligence for the detection of substance misuse from the electronic health record (EHR). Development and validation of the substance misuse classifier would enable a standardized approach to perform screening on all patient encounters on a daily basis in health systems. We will rigorously develop and test substance misuse classifier retrospectively and then examine its performance prospectively in both a naïve and mature screening program. This will serve as the first step towards a comprehensive universal screener that leverages available data in the EHR.

PI_NAMEs: AFSHAR, MAJID  (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: addiction;Admission activity;Adopted;Adult;alcohol misuse;alcohol use disorder;Alcohols;Artificial Intelligence;Benzodiazepines;Caring;Clinical;Clinical Data;clinical decision support;cohort;comparison intervention;Computing Methodologies;Consult;Cost Analysis;Costs and Benefits;Data;Data Set;design;Detection;Development;Documentation;Effectiveness;effectiveness evaluation;Electronic Health Record;General Population;Goals;Health Care Sector;Health system;Heart Diseases;Hospitalization;Hospitals;Hour;Illicit Drugs;improved;Individual;individual patient;Inpatients;Intake;interoperability;Interruption;Intervention;Interviewer;Label;Learning;Light;Machine Learning;machine learning method;Manuals;Methods;Modeling;Modernization;multitask;Natural Language Processing;non-opioid analgesic;novel;opioid misuse;Patient Self-Report;Patients;Performance;polysubstance use;Prevalence;primary care team;prospective;prospective test;Provider;Publishing;Questionnaires;Recommendation;Reference Standards;Research;Resources;Respiratory Failure;response;Risk;Risk Factors;routine care;screening;Screening procedure;screening program;Semantics;Sensitivity and Specificity;Series;Social Work;Source;Standardization;Substance Abuse Detection;substance misuse;substance use;substance use treatment;supervised learning;support tools;Testing;Text;Time;tool;Training;treatment as usual;trend;Trust;unstructured clinical data;Validation;Visit

PROJECT_TITLE: Data Driven Strategies for Substance Misuse Identification in Hospitalized Patients

STUDY_SECTION: BCHI

STUDY_SECTION_NAME: Biomedical Computing and Health Informatics Study Section[BCHI]


NIH_SPENDING_CATS: Microbiome

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE The human gut microbiome is a complex microbial ecosystem which impacts health in a myriad of ways. The proposed studies seek to determine the adaptations that allow different microbes to coexist within the gut. Results from these studies will advance a basic understanding of the gut microbiome and could clarify the significance of changes in the microbiome that occur in various diseases.

PI_NAMEs: LIGHT, SAMUEL  (contact)

PROJECT_TERMS: Biochemical;Biological Assay;comparative;Complex;diagnostic development;Disease;Ecosystem;Gastrointestinal tract structure;Genetic;genome analysis;Growth;guided inquiry;gut microbes;gut microbiome;gut microbiota;Health;Human;member;Microbe;microbial;microbial community;microbiome;microbiome therapeutics;Molecular;Nature;novel;Property;Research;Role;Technology

PROJECT_TITLE: Ecological niche assignment in the gut microbiome on an ecosystem-level scale

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-X(55)R]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;HIV/AIDS;Infectious Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human;Transplantation

ORG_CITY: STANFORD

ORG_DEPT: PEDIATRICS

ORG_NAME: STANFORD UNIVERSITY

PHR: Gene editing allows the potential of HIV patients to be cured by transplantation of a patient’s own blood stem cells after editing by deletion of required factors and addition of factors that inhibit virus replication. While stacking of these inhibitory factors in the primary infected cell, the CD4+ T cell, shows great promise there is a large variability in how efficiently the virus is inhibited. This proposal aims to understand the biology behind the virus and the knock-in factors in relation to human-specific differences in these and other cells relevant for infection in order to improve gene editing therapies.

PI_NAMEs: DUDEK, AMANDA M (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: adeno-associated viral vector;Alleles;Allogenic;Alternative Splicing;Anti-Retroviral Agents;antiretroviral therapy;Autologous;base editing;Biological Assay;Biology;Bone Marrow;CCR5 gene;CD34 gene;CD4 Positive T Lymphocytes;cell immortalization;Cell Line;Cell Transplantation;cell type;Cells;Characteristics;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;conditioning;CXCR4 gene;Cyclophilin A;cytokine;Data;Dendritic Cells;Disease;Disparity;Dominant-Negative Mutation;Engineering;gene editing technology;Gene Modified;gene-editing approach;Genes;Genetic Transcription;Goals;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;HIV;HIV Infections;HIV therapy;HIV-1;Human;improved;Individual;Infection;innovation;Intrinsic factor;Investigation;Ionomycin;Knock-in;Knock-out;Low Prevalence;Macrophage;Membrane;Memory;Modeling;Modification;Molecular;monocyte;Morbidity - disease rate;novel;Null Lymphocytes;Patients;Pattern;Peptides;Peripheral Blood Mononuclear Cell;Pharmacotherapy;prevent;Protein Isoforms;Proteins;Regimen;repaired;Resistance;resistance mutation;response;Rhesus;stem cell therapy;Stem cell transplant;stem cells;T-Lymphocyte;T-Lymphocyte Subsets;Techniques;Testing;Therapeutic;therapeutic genome editing;Toxic effect;Transplantation;Treatment Efficacy;TRIM Gene;TRIM5 gene;Umbilical Cord Blood;Viral;Viral Proteins;viral rebound;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Mechanisms that Enhance and Suppress HIV-1 Resistance in Gene Edited Primary Human Cells

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


NIH_SPENDING_CATS: Genetics;Hearing Loss;Neurosciences

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative Neural circuits that transmit sound from the ear to the brain rely on precise connections with their appropriate partners. Disruption of this can lead to sensorineural hearing loss, or “nerve deafness”. The work described here, aims to understand how neural circuits in the auditory system are established in normal hearing to better understand disease, and improve prevention and treatment strategies.

PI_NAMEs: WEBBER, JEMMA LOUISE (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Address;Afferent Neurons;Area;Auditory;Auditory Perception;Auditory system;Award;axonal pathfinding;Back;Biological Models;Brain;Brain Stem;Caenorhabditis elegans;Candidate Disease Gene;career;cell transformation;cell type;Cells;Central Nervous System;Cochlea;Cochlear duct;Communities;deafness;Defect;Development;Disease;Drosophila genus;Ear;Efferent Neurons;Embryo;Epithelium;Feedback;Fiber;Funding;Future;Genes;Goals;Grant;Hair Cells;Hair Removal;Hearing;hearing impairment;hearing loss treatment;Homologous Gene;improved;Inner Hair Cells;Institution;insulinoma associated 1;Journals;Knowledge;Labyrinth;Lateral;Location;Medial;Mentors;Modeling;Molecular;mouse genetics;mouse model;Mus;mutant;Nerve;nerve supply;neural circuit;Neurobiology;Neurologic;neuronal circuitry;Neurons;normal hearing;novel;Organ of Corti;Outer Hair Cells;Pain;Pathway interactions;Pattern;Persons;Pharmacotherapy;Phenotype;Positioning Attribute;Prevention strategy;Publishing;Quality of life;Receptor Cell;regenerative therapy;Reporting;Research;Research Personnel;Resources;ribbon synapse;Role;Sensorineural Hearing Loss;Sensory;Sensory Receptors;sound;spiral ganglion;success;Synapses;Technical Expertise;tenure track;Testing;transcription factor;Transcriptional Regulation;transcriptome sequencing;transdifferentiation;transmission process;treatment strategy;Universities;Vestibular dysfunction;Vestibular ganglion;vestibular system;Viral Vector;Work;Zinc Fingers

PROJECT_TITLE: Development of Afferent and Efferent Innervation in the Inner Ear

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ORG_CITY: BATON ROUGE

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: Project narrative Lysosomes are major digestive organelles that sustain cellular homeostasis by degrading damaged proteins and organelles and recycling the constituents back into the cytoplasm. Lysosome defects are attributed to several metabolic and degenerative diseases. We are studying a novel class of tubular lysosomes and their function in healthy and disease contexts.

PI_NAMEs: JOHNSON, ALYSSA  (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TITLE: Tubular lysosomes in health and disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Genetics

ORG_CITY: LINCOLN

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: PROJECT NARRATIVE This project will determine the structures and interactions of regulatory RNA elements with ligand or protein cofactors at atomic resolution to gain a foundational understanding of molecular recognition and role of ribonucleoproteins in human health and disease. The research is expected to significantly improve our understanding of the structural basis for RNA molecular recognition, ribonucleoprotein assembly and mechanisms of action.

PI_NAMEs: EICHHORN, CATHERINE  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: 2019-nCoV;Address;Adopted;aptamer;Architecture;Binding;Biochemistry;Biological Models;Biological Process;Biology;Cell Physiology;cofactor;Complex;Disease;Dwarfism;Elements;Genetic Diseases;Genetic Transcription;Genotoxic Stress;Health;Heart Diseases;HIV-1;Human;improved;insight;interdisciplinary approach;Knowledge;Ligands;Malignant Neoplasms;Mass Spectrum Analysis;Molecular;molecular assembly/self assembly;Molecular Conformation;molecular recognition;NMR Spectroscopy;Normal Cell;Phosphotransferases;Polymers;Positive Transcriptional Elongation Factor B;programs;protein complex;protein protein interaction;Proteins;Proteome;rational design;Research;Resolution;response;Ribonucleoproteins;RNA;RNA Conformation;RNA Folding;RNA Polymerase II;RNA-Binding Proteins;RNA-Protein Interaction;Role;small molecule;Specificity;Stimulus;structural biology;Structure;Viral;Virus;Work;X-Ray Crystallography

PROJECT_TITLE: Structural dynamics of regulatory RNAs and ribonucleoproteins

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Physician-scientists have an important role in developing new therapies for disease. However, the numbers of physician-scientists have been declining. This grant develops a research program to train physician-scientists in neurology using an innovative program of laboratory or clinical research training, close mentoring and didactics in grant writing and research ethics. Relevance to Public Health: This grant will develop physician scientists in neurology that will develop new therapies for human diseases.

PI_NAMEs: CARMICHAEL, STANLEY THOMAS (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Address;Ally;Applications Grants;Basic Science;Brain Neoplasms;Budgets;career development;Clinical;clinical application;Clinical Research;Clinical Sciences;clinical training;Clinical Treatment;Communities;Conduct Clinical Trials;design;Disease;Education;education research;Emergency Medicine;Environment;Epilepsy;experience;falls;Fellowship;flexibility;Funding;genetic signature;Goals;Grant;human disease;human model;innovation;K-Series Research Career Programs;Laboratory Research;Medicine;Mentors;Mentorship;Nature;nerve stem cell;Neurologist;Neurology;neuropathology;Neurosciences;Neurosciences Research;neurosurgery;novel;novel therapeutics;Oral;Parkinson Disease;Physicians;Play;Positioning Attribute;Production;progenitor;programs;Public Health;Research;Research Ethics;research faculty;Research Training;Residencies;Role;Scientist;Stroke;Structure;Time;Training;Training Programs;translational neuroscience;Translations;United States National Institutes of Health;Writing

PROJECT_TITLE: Neurology Physician Research Training Grant


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE Tuberculosis is a massive public health problem, and new drug regimens are sorely needed. To address this need, we are assembling a multifactorial pipeline of experiments and computation to understand how drugs interact and to drive regimen development for TB. Our work will establish a tool for rapid assessment of TB drug combinations and a framework for applying this approach to other conditions where new multidrug therapies are needed.

PI_NAMEs: SHERMAN, DAVID R (contact)

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: Acceleration;Address;Affect;Algorithms;antagonist;Antibiotics;Antitubercular Agents;Clinical;clinically relevant;combat;combinatorial;Communicable Diseases;Computational Biology;cost;Data;design;Development;Disease;Drug Combinations;drug efficacy;Drug Interactions;Drug resistance in tuberculosis;Drug Synergism;Environment;experimental study;Generations;Genes;Genetic;genetic signature;global health;Goals;Growth;Human;Hypoxia;improved;in silico;In Vitro;in vivo;Individual;Infection;Intuition;Knowledge;Life;Link;machine learning algorithm;Malignant Neoplasms;Measurement;Measures;Modeling;Molecular;mouse model;Multi-Drug Resistance;Multidrug-Resistant Tuberculosis;Mus;Mycobacterium tuberculosis;new combination therapies;novel drug combination;novel therapeutics;Nutrient;Outcome;pandemic disease;Persons;Pharmaceutical Preparations;Pharmacotherapy;pre-clinical;preclinical development;predictive modeling;Predisposition;Process;programs;Public Health;Regimen;relapse patients;Resistance;response;Risk Reduction;Speed;Stress;synergism;Testing;Therapeutic;tool;transcriptome;transcriptomics;Tuberculosis;tuberculosis drugs;tuberculosis treatment;Work;Writing

PROJECT_TITLE: A multifactorial pipeline to dissect combinatorial drug efficacy in Tuberculosis

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Prevention

ORG_CITY: KARACHI

ORG_COUNTRY: PAKISTAN

ORG_FIPS: PK

ORG_NAME: AGA KHAN UNIVERSITY (PAKISTAN)

PHR: PROJECT NARRATIVE Pakistan, a low-middle income, and 5th most populous country has limited capacity to address its existing non-communicable disease (NCD) crisis. Leveraging existing infrastructure at the Aga Khan University’s flagship program in Karachi, Pakistan, the extensive Aga Khan Development Network and long-standing collaborations with Duke University, we have designed a robust, integrated, multi-disciplinary research- training program targeting cardio-cerebrovascular diseases and their risk factors with a prioritization of surveillance and implementation research methods that leverage big data and m-health. We expect that this program will directly increase Pakistan’s research capacity, a critical element in a comprehensive NCD response. 1

PI_NAMEs: ALMAS, AYSHA ;BLOOMFIELD, GERALD SAMUEL;KAMAL, AYEESHA KAMRAN;SAMAD, ZAINAB  (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Big Data;Cerebrovascular Disorders;Cessation of life;cost;Data;design;Development;digital;Disease;Disease Management;Disease Surveillance;disorder prevention;Elements;Epidemic;Faculty;Funding;global health;Health;implementation science;Information Technology;Infrastructure;insight;Lead;Leadership;life span;low and middle-income countries;multidisciplinary;neurovascular;next generation;Pakistan;Pathway interactions;premature;Prevalence;programs;Research;Research Personnel;Research Training;Resources;response;Risk Factors;risk sharing;Site;social determinants;Testing;Training;Training Programs;United States;Universities;Vision;Work

PROJECT_TITLE: The Aga Khan University Pakistan Initiative for Non-Communicable Diseases (AKUPI-NCDs) Research Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-L(55)R]


ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE This proposal will increase our understanding of how the immune system causes disease when it incorrectly recognizes and responds to self-molecules as a threat. By providing understanding of autoimmunity to lipids or “fats” the outcome of this proposal has the potential to redefine Type 2 Diabetes as an autoimmune disease. This will provide new strategies for management of Type 2 Diabetes and new targets for therapeutic development.

PI_NAMEs: NICHOLAS, DEQUINA ANGELINA (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: 3D Print;Adipose tissue;American;Anti-Inflammatory Agents;Antibodies;Antigen Presentation;Antigen-Presenting Cells;Antigens;Area;Autoantibodies;Autoantigens;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;Automobile Driving;B-cell receptor repertoire sequencing;B-Lymphocytes;Biochemistry;Biological Assay;Biological Models;Blood specimen;CD1 Antigens;Cell Physiology;Cells;Chronic;Color;Communities;Complement;Computer Models;Computing Methodologies;Coupled;Creativeness;Custom;cytokine;Development;Disease;Disease Management;Enzyme-Linked Immunosorbent Assay;Fatty acid glycerol esters;Fatty Acids;Flow Cytometry;Goals;Health;High Fat Diet;Homeostasis;Human;human model;humanized mouse;Immune;immune function;Immune response;Immune system;Immunologics;Immunophenotyping;In Vitro;in vitro Model;in vivo;Inflammation;Inflammatory;Inflammatory Response;innovation;Insulin Resistance;Investigation;Laboratories;Left;Lipids;Mediating;Molecular Biology Techniques;mouse model;Mus;Nature;neutralizing antibody;new technology;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;novel;Outcome;Pathway interactions;Patients;Persons;Phenotype;Postdoctoral Fellow;prevent;Protein Analysis;Protein Engineering;Proteins;Research;response;Role;Sampling;Saturated Fatty Acids;Serum;single-cell RNA sequencing;Systems Biology;T cell response;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;therapeutic development;Transgenic Mice;Transgenic Organisms;translational potential;Triglycerides;Work

PROJECT_TITLE: Lipid Antigen Presentation as a Driver of T2D Inflammation


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse;Women's Health Research

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Project Narrative Exposure to opioids in the womb can lead to severe neurological and psychiatric disorders that last till adolescence or even adulthood. To understand how these conditions occur, and how to treat them, we will study, in mice, how exposure to opioids in the womb affect the adolescent brain. We will provide critical new information on the circuit, cellular, and molecular processes disrupted by this exposure.

PI_NAMEs: AMENT, SETH ABRAMS;KELLER, ASAF ;LOBO, MARY KAY  (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: addiction;Adolescence;Adolescent;Adult;Affect;Age;Animals;Anxiety;anxiety-like behavior;Behavior;Behavioral;behavioral outcome;Brain;Candidate Disease Gene;cell type;Cells;child bearing;Childhood;Clustered Regularly Interspaced Short Palindromic Repeats;Cognitive;Data;density;Dependence;Diagnosis;Dopamine Receptor;Electrophysiology (science);Emotional;emotional behavior;Enrollment;Epidemic;epigenome editing;Exposure to;Female Adolescents;Fentanyl;fentanyl exposure;Functional disorder;Gene Expression;Genes;Goals;Health;Human;Immunohistochemistry;Impairment;Incidence;Infant;Life;Male Adolescents;Medial;Mediating;Medicaid;Mental disorders;Messenger RNA;Molecular;Molecular Abnormality;Mothers;Motivation;mouse model;Mus;nano-string;Nervous System Disorder;neural circuit;neurobiological mechanism;Neurobiology;Neurodevelopmental Problem;Neurologic Effect;Neurons;Newborn Infant;Nucleus Accumbens;offspring;Opioid;opioid abuse;opioid exposure;opioid misuse;opioid use;Outcome;Patient Self-Report;Perinatal;Perinatal Exposure;Physiological;Population;Prefrontal Cortex;Pregnancy;Pregnant Women;prescription opioid;Prevalence;Prevention;Process;Property;Regulation;reward circuitry;Risk;Role;Sensory;sex;single nucleus RNA-sequencing;Synapses;Testing;Time;tool;transcriptome;Uterus;Vertebral column;virtual;Weaning;Woman

PROJECT_TITLE: Lasting Neurological Effects of Perinatal Opioids

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Chronic Obstructive Pulmonary Disease;Clinical Research;Emerging Infectious Diseases;Health Services;Infectious Diseases;Lung;Orphan Drug;Patient Safety;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE 155 million people living in the world today have survived tuberculosis (TB) and many will continue to suffer from post-TB lung disease (PTLD). If successful, the proposed studies will help target interventions that can mitigate ongoing morbidity by better characterizing changes in lung function following TB treatment and facilitating earlier identification of patients at risk for developing PTLD in resource-limited settings where spirometry is not currently feasible.

PI_NAMEs: HUDDART, SOPHIE  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Acoustics;Adherence;Aftercare;Area;career;career development;Characteristics;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Clinical;Cohort Studies;compliance behavior;Coughing;Country;COVID-19;Cross-Sectional Studies;Data;Dedications;design;Disease;Early identification;Early Intervention;Environment;epidemiologic data;Evolution;experience;feature selection;Frequencies;Future;Goals;health related quality of life;Impairment;improved;improved outcome;International;Intervention;Life Cycle Stages;Lung;Lung Diseases;Machine Learning;Measurement;Measures;medication compliance;Mentored Research Scientist Development Award;Mentorship;Methods;mobile application;Modeling;Monitor;Monitoring for Recurrence;Morbidity - disease rate;mortality;multidisciplinary;novel;novel strategies;Obstruction;Outcome;Outcome Assessment;outcome prediction;Outcomes Research;Output;Patient-Focused Outcomes;Patients;Pattern;Persons;Pharmaceutical Preparations;Predisposition;Prospective, cohort study;Proxy;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;pulmonary symptom;Pulmonary Tuberculosis;Recurrence;Research;research and development;Research Personnel;Resource-limited setting;Resources;respiratory;Risk;Risk Factors;risk stratification;Schedule;Site;sound;Spirometry;Testing;tool;Training;treatment adherence;treatment duration;Treatment Factor;Treatment outcome;Tuberculosis;tuberculosis treatment;United States National Institutes of Health;Visit;Work

PROJECT_TITLE: Identifying patients at risk of post-tuberculosis lung disease using novel cough and adherence predictors

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Mental Health;Prevention

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE In sub-Saharan Africa, men consistently lag behind women along each step of the HIV care cascade and contribute to HIV transmission among women. HIV disclosure is a key step in HIV prevention, however, few evidence-based resources exist to support HIV disclosure among men with HIV in sub-Saharan Africa. I propose to develop and pilot test an HIV disclosure intervention to support men with HIV with STI symptoms who are either not accessing antiretroviral therapy or are accessing antiretroviral therapy but without viral suppression, with the goal of engaging men in care and decreasing partner HIV transmission.

PI_NAMEs: CHITNENI, POOJA RAO (contact)

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: acceptability and feasibility;Adherence;Africa South of the Sahara;AIDS prevention;antiretroviral therapy;Attention;Behavior;Behavior Therapy;behavioral clinical trial;Behavioral Sciences;Biometry;career development;Caring;Clinical;clinical care;Clinical Investigator;clinical trial analysis;clinical trial implementation;Cognitive Therapy;cohort;Communication;community advisory board;Control Groups;Counseling;Data;Dedications;Development;Diagnosis;Disclosure;Education;efficacy evaluation;Elements;Eligibility Determination;Enrollment;Ensure;Epidemic;Epidemiology;Event;evidence base;experience;Family;Focus Groups;Funding;Future;Gender;Goals;Health;Healthcare;HIV;HIV risk;Human immunodeficiency virus test;improved;innovation;Institution;Intervention;Intervention Trial;Interview;male;male health;Manuals;Masculine;Measures;meetings;men;Mentors;Mentorship;Methods;Modeling;novel;Obesity;Outcome;Participant;Partner Notification;Patient Self-Report;Persons;Physiological;pilot test;Positioning Attribute;preference;Prevention;primary outcome;Problem Solving;Process;Qualitative Methods;Randomized;Randomized, Controlled Trials;Reaction;recruit;Reporting;Research;Research Personnel;Resource-limited setting;Resources;Risk;Risk Reduction;Role playing therapy;Rural;Sampling;Scientist;Sexual Partners;sexual risk taking;Sexually Transmitted Diseases;skills;social stigma;Social support;Southern Africa;STI prevention;success;Symptoms;theories;therapy adherence;therapy development;tool;Training;transmission process;treatment as prevention;Treatment Efficacy;Uganda;United States National Institutes of Health;uptake;Viral;Viral Load result;Woman;Work

PROJECT_TITLE: Development and assessment of an HIV disclosure intervention for men in Uganda

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Nanotechnology;Sexually Transmitted Infections

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative Section We will harness a recent breakthrough in plasmon-enhanced fluorescence technology to create a new antigen test for Neisseria gonorrhoeae (Ng) that is as accurate and reproducible as gold standard nucleic acid amplification tests, but one that is cheaper, faster, and simpler. We will verify the efficacy of Ng antigen test by utilizing remnant urine samples from patients with suspected Ng infection. If successful, this test will have a tremendous positive impact immediately as it will transform the diagnostic landscape for Ng testing by its scalability with an inexpensive test strip and minimal battery-powered portable equipment, without relying on skilled personnel.

PI_NAMEs: GANDRA, SUMANTH  (contact);SINGAMANENI, SRIKANTH

PROGRAM_OFFICER_NAME: GLOCK, JONATHAN A

PROJECT_TERMS: Accounting;Address;antigen detection;Antigen Presentation;antigen test;Antigens;Antimicrobial Resistance;Biological Assay;Cells;Centers for Disease Control and Prevention (U.S.);Characteristics;Chlamydia;Clinical;Clinical Sensitivity;Communicable Diseases;cost;COVID-19 detection;detection assay;detection limit;detection test;Development;Devices;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic technologies;Diagnostic tests;Enzyme-Linked Immunosorbent Assay;Equipment;Feasibility Studies;Flour;Fluorescence;fluorophore;follower of religion Jewish;Future;Generations;Goals;Gonorrhea;Health;healthy volunteer;Hospitals;Human Resources;improved;Incidence;Infection;infection rate;innovation;instrumentation;Investigation;Label;Laboratories;lateral flow assay;Life;Lipoproteins;low and middle-income countries;Methods;Microbiology;Molecular;nano;nanoGold;nanolabel;Nature;Neisseria gonorrhoeae;novel;Nucleic Acid Amplification Tests;Nucleocapsid Proteins;Outcome;Patients;Persons;plasmonics;point of care;point of care testing;portability;Process;prototype;Public Health;Rapid diagnostics;Reader;Reporting;repository;Reproducibility;Research;Resolution;Resource-limited setting;Resources;Running;Sampling;SARS-CoV-2 antigen;screening;Sensitivity and Specificity;Sexually Transmitted Diseases;Signal Transduction;skills;Specificity;Specimen;Speed;Surface;Technology;test strip;Testing;Time;tool;Trichomonas Infections;United States;Urine;Validation;Work

PROJECT_TITLE: Ultrasensitive Point of Care Antigen Test for Detection of Neisseria Gonorrhoeae Using Plasmonic Flours

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-U(02)]


NIH_SPENDING_CATS: Genetics;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

PHR: Public Health Relevance: Studies in this proposal will explore how the noncanonical Wnt ligands, Wnt11 and Wnt5a, that are expressed by primitive mesenchymal stem/progenitor cells (MSC) in the bone marrow (BM), preserve self-renewal and multilineage developmental potential of both bone-forming MSC and blood-forming long-term self-renewing hematopoietic stem cells (LT-HSC). These Wnt ligands significantly enhance expansion of LT-HSC in vitro when LT-HSC are co-cultured for extensive time periods with primary MSC. Insights gained from studies in this proposal may therefore have significant application in efforts aimed to preserve LT-HSC and MSC function in vitro during manipulations used in various gene targeting approaches, for improving the efficacy of bone marrow transplantation, and for development of protocols to enhance bone regeneration following injury.

PI_NAMEs: KLUG, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Ablation;Address;Adipocytes;Adult;Alleles;alpha catenin;arteriole;beta catenin;Binding;Biological Assay;Blood;Blood Cells;Blood Vessels;bone;Bone Marrow;Bone Marrow Transplantation;Bone Regeneration;Cartilage;Cell Differentiation process;Cell Line;Cell Lineage;Cell Physiology;Cell surface;cell type;Cells;Chondrocytes;Chromatin;Clinic;Clonal Hematopoietic Stem Cell;Coculture Techniques;confocal imaging;defined contribution;Deposition;Development;Ectopic Expression;Embryo;Endothelial Cells;Enterobacteria phage P1 Cre recombinase;Feedback;gene correction;Gene Expression;Gene Expression Profile;Gene Targeting;Genes;genetic signature;Goals;Growth;Hematopoiesis;Hematopoietic;hematopoietic stem cell quiescence;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Homeostasis;Image;improved;In Vitro;in vivo;inducible Cre;insight;interest;Knowledge;leptin receptor;Ligands;LoxP-flanked allele;Macrophage;Maintenance;MCAM gene;Megakaryocytes;Membrane;Mesenchymal Differentiation;Mesenchymal Stem Cells;mesenchymal stromal cell;Molecular;Mus;nestin protein;Neurons;Newborn Infant;old mice;optical imaging;Osteoblasts;osteogenic;overexpression;Pathway interactions;Patients;Platelet-Derived Growth Factor alpha Receptor;preservation;Production;programs;protocol development;public health relevance;receptor;reconstitution;regeneration following injury;Regulation;Reporter;Role;self-renewal;Signal Transduction;single-cell RNA sequencing;skeletal stem cell;Sorting;Source;stem cell biomarkers;Stem Cell Factor;stem cell population;stem cell self renewal;Stem cell transplant;stem cells;stemness;Stress;Stromal Cell-Derived Factor 1;Stromal Cells;stromal progenitor;substantia spongiosa;Supporting Cell;Time;tissue repair;Transgenes;Transplantation;Up-Regulation;WNT Signaling Pathway;WNT9A gene

PROJECT_TITLE: Defining the role of Wnt11 and Wnt5a in regulating hematopoietic and skeletal stem cell self-renewal potential during homeostasis and stress

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Genetics;HIV/AIDS

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: Project Narrative Reverse transcription is a highly regulated process in HIV. The investigation of the complexes proposed in this study will elucidate key structure-based mechanisms involved in ensuring accurate initiation.

PI_NAMEs: D'SOUZA, VICTORIA MANUEL (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TITLE: Structural understanding of the HIV-1 reverse transcription initiation process

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ORG_NAME: JOSLIN DIABETES CENTER

PHR: PROJECT NARRATIVE This proposal is aimed at exploring the cross talk between the exocrine and endocrine cells of the pancreas. The focus is centered on understanding the intercellular communication between key players in the pancreatic niche that can directly impact the function of islet cells. The long-term objective is to use the information obtained from the experiments in these studies to gain a higher resolution understanding of the mechanisms that underlie the pathogenesis of type 1 diabetes.

PI_NAMEs: DAS, SAUMYA ;DOMINGUEZ-BENDALA, JUAN ;KULKARNI, ROHIT N. (contact)

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: 2'-Deoxythymidine;Acinar Cell;Adult;Anatomy;Autophagocytosis;Beta Cell;Biological Models;Biology;blood glucose regulation;Cardiovascular Diseases;Cause of Death;Cell Communication;Cell Line;Cell Physiology;Cell secretion;cell type;Cells;Cellular biology;Cellular Stress;Cessation of life;Coculture Techniques;combat;Communication;Communities;Complement;Data;Data Set;Defect;Development;Diabetes Mellitus;diabetes risk;Disease;Disease Progression;Duct (organ) structure;Ductal Epithelial Cell;Embryonic Development;Endocrine;endoplasmic reticulum stress;Esters;Exhibits;Exocrine pancreas;exosome;experimental study;Extracellular Space;extracellular vesicles;Functional disorder;Gene Mutation;gene product;Genes;Genetically Engineered Mouse;Goals;Growth;Hip region structure;Hormones;Human;human disease;human induced pluripotent stem cells;humanized mouse;in vitro Model;in vivo;in vivo Model;Incubated;insight;insulin secretion;Insulin-Dependent Diabetes Mellitus;intercellular communication;islet;Islet Cell;Kidney Failure;Label;Lipase;lipid disorder;Malignant neoplasm of pancreas;Malignant Neoplasms;Metabolic;Modeling;Molecular;Morbidity - disease rate;mutant;Mutation;non-diabetic;novel;Organoids;Outcome;Output;Pancreas;Pancreatic Diseases;Pancreatitis;paracrine;Pathogenesis;Pathway interactions;Patients;Physiology;Process;Property;Reagent;Research;Resolution;Resources;risk variant;Role;Secondary to;senescence;Slice;Small RNA;stress granule;Testing;Therapeutic;Tissues;Transfer RNA;transmission process;Transplantation;uptake;Variant

PROJECT_TITLE: Using ex vivo, in vivo models and patient mutations to interrogate pancreatic exocrine-endocrine cross talk


NIH_SPENDING_CATS: Data Science

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: NARRATIVE The unprecedented availability of increasingly complex, voluminous, and multi-dimensional data and the emergence of data science as a field to harness it provide ideal opportunities to address the multi-faceted public health challenges faced by countries in sub-Saharan Africa. However, there is a severe lack of well-trained data scientists and home-grown educational programs to enable context-specific training. This proposal describes a plan to establish sustainable research training programs and to train a new generation of data scientists with skills, knowledge, mentoring, professional skills, and research immersion to position them for rigorous, biomedically grounded, and ethically conscious public health data science practice.

PI_NAMEs: BEKELE, RAHEL ;BERHANE, KIROS T (contact);WEKE, PATRICK OLOO

PROGRAM_OFFICER_NAME: POVLICH, LAURA

PROJECT_TERMS: Achievement;Address;Africa;Africa South of the Sahara;African;Algorithms;Big Data;climate change;Collaborations;Communicable Diseases;Communities;Complex;Data;Data Science;Data Scientist;Degree program;design;Development;Doctor of Philosophy;Eastern Africa;Education;Educational Curriculum;Educational workshop;Environmental Health;Ethiopia;Evaluation;experience;Faculty;faculty mentor;Funding;Goals;Grouping;Growth;Health;health data;Health system;Home;Immersion;Institution;Kenya;Learning Skill;life-long learning;member;Monitor;Occupational Exposure;open data;Persons;Play;Policies;Private Sector;programs;Public Health;Public Health Practice;public health research;Publications;Readiness;Research;Research Personnel;Research Project Grants;Research Training;Role;Scientist;skills;Structure;success;Techniques;Training;training data;Training Programs;Universities

PROJECT_TITLE: Advancing Public Health Research in Eastern Africa through Data Science Training  (APHREA-DST)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-C(70)]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Hematology;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: SALT LAKE CITY

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative In this proposal, we aim to use synthetic biology approaches to engineer synthetic gene networks to create engineered platelets for immunomodulation. The genetic tools build in this proposed work will have a broad yet significant impact on inflammatory disease treatments.

PI_NAMEs: DEANS, TARA LYNN (contact)

PROGRAM_OFFICER_NAME: RUSSELL, LUISA MARIE

PROJECT_TERMS: angiogenesis;Apoptosis;Behavior;Binding;Blood Cells;Blood Platelets;Cell Fate Control;Cell Therapy;Cells;Coagulation Process;Cytoplasmic Granules;delivery vehicle;design;design,build,test;Disease;Drug Delivery Systems;Emigrations;Engineering;Event;Excision;flexibility;Gene Expression;gene network;Genetic;Goals;Harvest;Hematopoiesis;Hematopoietic;hematopoietic differentiation;hematopoietic stem cell differentiation;Hematopoietic stem cells;Hemostatic function;Immune;Immune system;immunoregulation;In Vitro;in vitro Assay;Infection;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;Injury;Invaded;Learning;Link;Measures;Mediating;Medical Technology;Megakaryocytes;Membrane;microorganism;migration;Migration Assay;Molecular;Mutate;neutrophil;Neutrophil Infiltration;non-Native;novel therapeutic intervention;Operative Surgical Procedures;pathogen;Pathogenicity;Pathway interactions;Perfusion;Pharmacologic Substance;Physiological Processes;Platelet Activation;Play;pluripotent stem cell differentiation;Pluripotent Stem Cells;Process;Production;programs;Proteins;recruit;Reporter;Research;Resolution;response;Role;Secretory Vesicles;Signal Transduction;Site;stem cell differentiation;success;synthetic biology;Synthetic Genes;technology platform;Therapeutic;therapeutic evaluation;therapeutic gene;therapeutic protein;Thrombin;tissue injury;Tissues;tool;trafficking;Transcription Coactivator;Transcription Repressor;Transcriptional Regulation;Tumor Necrosis Factor Ligand Superfamily Member 6;Vision;Work;wound healing

PROJECT_TITLE: Synthetic circuits for therapeutic platelet production and immunomodulation

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Congenital Structural Anomalies;Genetics;Kidney Disease;Networking and Information Technology R&D (NITRD);Pediatric;Polycystic Kidney Disease

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Biophysical properties of cells are important to maintain tissue homeostasis. We hypothesize that the imbalance of cellular biomechanics is a driver of renal cystogenesis. We propose to combine computational and cell biology approaches to study the disregulation of the biophysical mechanisms that underlie tissue malformation and disease progression.

PI_NAMEs: AZELOGLU, EVREN U.;GUSELLA, GABRIELE LUCA  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: 3-Dimensional;Ablation;absorption;Adhesions;Adhesives;Affect;Anatomy;Apical;Architecture;Atomic Force Microscopy;Autosomal Dominant Polycystic Kidney;Biological;Biological Assay;Biological Models;biomechanical test;Biomechanics;biophysical model;Biophysical Process;biophysical properties;Biophysics;Biosensor;Calcium;cell growth;Cell Maintenance;cell motility;Cell Physiology;Cell Polarity;Cell-Cell Adhesion;Cell-Matrix Junction;Cells;Cellular biology;cellular imaging;Cilia;ciliopathy;Computational Biology;computer studies;Cues;Cyst;Cytoskeleton;Data;data integration;Development;Disease;Disease Progression;ECM receptor;Elasticity;Ensure;Epithelial Cells;Epithelium;Equilibrium;experimental study;Extracellular Matrix;Fluorescence Resonance Energy Transfer;Focal Adhesions;Gene Expression Regulation;Gene Silencing;Genes;Genetic Models;Guanosine Triphosphate Phosphohydrolases;Homeostasis;Hybrids;Image Analysis;imaging system;Impairment;in vivo;Integrins;Intercellular Junctions;Kidney;Knock-out;Knockout Mice;Lead;Legal patent;live cell imaging;Maintenance;malformation;Maps;Measures;Methods;Modeling;Morphology;mouse genetics;mouse model;mutant;Mutation;new therapeutic target;Onset of illness;Organ;Pathologic;Pathway Analysis;Pathway interactions;Phenotype;Physics;Physiological;PKD1 gene;planar cell polarity;polarized cell;Polycystic Kidney Diseases;prevent;Process;Production;Proliferating;Property;Proteins;proteomic signature;reconstitution;Renal function;Reporter;response;rho;Role;segregation;Signal Pathway;Signal Transduction;Structure;Testing;therapeutic target;tissue repair;Tissues;Traction;transcriptomics;Tubular formation

PROJECT_TITLE: Biomechanical drivers of cystogenesis

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


PHR: Although the cellular metabolism seems to play a critical role in dictating the severity of pathogenic infection (i.e., asymptomatic, mild, and severe) or in controlling both genetic and epigenetic phenomena in a cancer cell, whether or to what extent dynamic metabolic shifts occur in the host’s immune system and if the changes in temporal ‘reactomics’ (defined as a combination of reaction mechanisms, regulations, and kinetic parameters) are the dominant drivers of metabolic reprogramming in a cancer cell, still remain to be explored. To this end, computational systems modeling framework provides the capability to represent these diseases as integrated/interacting systems and probe the changes in metabolic dynamics or temporal reactomics which can, ultimately, lead to identify alternate drug targets and help develop effective therapeutics. The proposed work aims to develop a comprehensive computational modeling and data integration platform to simulate the dynamic changes in metabolism and temporal reactomics that can be used to identify targets (i.e., genes/proteins/reactions) as either prognostic biomarkers or therapeutic targets or both to assess and/or intervene progression and worst outcomes during a disease period.

PI_NAMEs: SAHA, RAJIB  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: 2019-nCoV;Biological Models;cancer cell;Cells;Cellular Metabolic Process;Communities;Computer Models;data integration;Data Set;Databases;Disease;Drug Targeting;Epigenetic Process;experience;Genes;Genetic;Immune;Immune response;Immune system;Immunological Models;improved;Infection;kinetic model;Kinetics;Laboratories;Lead;Macrophage;Malignant Neoplasms;Metabolic;metabolic phenotype;Metabolism;Methods;Modeling;Molecular;multi-scale modeling;neoplastic cell;novel therapeutic intervention;Organ;Outcome;pancreatic ductal adenocarcinoma cell;pathogen;Pathogenicity;Play;predictive modeling;Prognostic Marker;programs;Proteins;Reaction;Regulation;Research;response;Role;Severities;Severity of illness;skills;Staphylococcus aureus infection;Symptoms;System;Testing;therapeutic target;therapeutically effective;translational scientist;Work

PROJECT_TITLE: A Predictive Modeling Framework to Dissect the Dynamic Immunometabolic Responses to Pathogenic infection and the Kinetic Reprogramming of Metabolism in Cancer Cell System

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-R(55)R]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Back Pain;Bioengineering;Biomedical Imaging;Chronic Pain;Clinical Research;Pain Research

ORG_CITY: Newark

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Project Narrative  Low back pain (LBP), the leading cause of disability, is often attributed to pathological disc mechanics; unfortunately, in vivo measures of structural changes from magnetic resonance images, which are believed to relate to pathology, have had very little success discriminating pathology from natural aging. To study and treat LBP, a technique needs to be developed to quantify disc mechanical function in vivo; the goal of this proposal is to provide this technique, establish a new degeneration classification, and predict the mechanical state throughout the disc for in vivo movements. The overall impact of this research will establish techniques for basic and clinical research to address mechanisms of degenerative disc disorders, and in the longer term, a clinical tool for diagnosis and assessment of disc treatment for LBP.

PI_NAMEs: ELLIOTT, DAWN M (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: 3-Dimensional;Abate;Address;Age;Aging;Basic Science;Biological Assay;Biomechanics;Cellularity;Classification;Clinical;Clinical Research;cohort;Diagnosis;disability;Disease;Elements;fluid flow;Functional disorder;Geometry;Goals;Health;Human;Image;In Vitro;in vivo;in vivo imaging;Individual;Intervertebral disc structure;intervertebral disk degeneration;Link;Low Back Pain;Magnetic Resonance Imaging;Maps;Measurement;Measures;Mechanical Low Back Pain;Mechanics;Modeling;Movement;normal aging;novel therapeutics;Pain;Pathologic;Pathology;Patients;Physiology;Positioning Attribute;Posture;pressure;Property;Research;sex;Specimen;Statistical Models;Stress;Structure;success;Supination;Symptoms;System;Techniques;Time;Tissues;tool;trait;Translations;Vertebral column;Work

PROJECT_TITLE: Disc mechanics and altered loading in degeneration

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Lymphatic Research;Lymphoma;Rare Diseases;Skin Cancer

ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE We have previously identified the role of the Interleukin-15 (IL-15) in the development of of cutaneous T-cell lymphoma (CTCL) in humans and mice. In order to understand how IL-15 is produced and how it drives the colonization of neoplastic T-cells in the skin, we have proposed a series of studies that will examine the interactions between tunor cells, immune cells and skin cells. These studies will also examine the efficacy of IL- 15 blocking antibodies that can prevent the progression of this disease.

PI_NAMEs: MISHRA, ANJALI  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: autocrine;Binding;Biological;Blocking Antibodies;Blood;cancer cell;CCR5 gene;CCR8 gene;Cell Adhesion Molecules;cell motility;Cell Motility Pathway;Cells;Characteristics;chemokine;chemokine receptor;ChIP-seq;Chronic;Clinical;clinical efficacy;clinically significant;Communication;Complication;Cutaneous T-cell lymphoma;cytokine;Data;demethylation;Development;Disease;Disease Progression;effective therapy;efficacy evaluation;Embryo;Evolution;Exposure to;Fatal Outcome;Foundations;Gene Activation;gene correction;Gene Expression;Genetic Transcription;Goals;Growth;Growth Factor;Hematologic Neoplasms;Homing;Human;Hypermethylation;Hyperplasia;IL15 gene;Immune;Immunity;In Vitro;in vivo;Incidence;Infiltration;Inflammation;Inflammatory;inflammatory milieu;Interleukin-15;Intervention;keratinocyte;knock-down;Lead;Ligands;Link;Lymphoma cell;Malignant - descriptor;Malignant Neoplasms;Measures;Mediating;Methylation;migration;Modeling;Morphogenesis;Motility;mouse model;Mus;Mycosis Fungoides;neoplastic;novel;Oncogenic;Organ;overexpression;paracrine;Pathway interactions;Patients;Pattern;pharmacologic;Phenotype;Play;prevent;Process;Production;Progressive Disease;Proliferating;promoter;Promoter Regions;Quality of life;recruit;Reporting;response;Role;Sampling;Series;Sezary Syndrome;Signal Pathway;Signal Transduction;Skin;skin lesion;skin organogenesis;Skin Tissue;Stimulus;System;T-Lymphocyte;Therapeutic;therapeutic target;trafficking;Transactivation;transcription factor;Transcriptional Activation;Transgenic Mice;Tropism;tumor;tumor microenvironment;Tumor-Derived

PROJECT_TITLE: The Role of IL-15 in Cutaneous T-cell Lymphoma Progression

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: DURHAM

ORG_DEPT: GENETICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Human centromeres, defined by a repetitive DNA sequence called alpha satellite that is present in thousands of copies on each chromosome, are genetic loci that are required for genome stability. Alpha satellite size and sequence variation negatively affects centromere assembly and chromosome stability. This research will use artificial chromosome technology to test competency of specific alpha satellite DNA conformations in de novo centromere formation and use CRISPR-based methods to rehabilitate centromeres and/or rescue chromosome defects.

PI_NAMEs: SULLIVAN, BETH A (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Address;Affect;Architecture;Area;Artificial Chromosomes;Artificial Human Chromosomes;Auxins;Award;Biological Assay;Biology;Bypass;Centromere;centromere protein A;Chimeric Proteins;Chromatin;Chromosomal Stability;Chromosome 17;Chromosome abnormality;chromosome movement;Chromosomes;Classification;Competence;Congenital Abnormality;Coupled;CRISPR/Cas technology;Defect;density;Dicentric chromosome;Disease;DNA;DNA Sequence;DNA Transposable Elements;Elements;Engineering;Epigenetic Process;Exhibits;experience;flexibility;functional outcomes;Genome;Genome engineering;Genome Stability;genomic locus;genomic variation;Genomics;Genotype;Goals;Homo sapiens;Human;Human Chromosomes;Human Genome;improved;Infertility;innovation;Kinetochores;Knowledge;Label;Link;Location;Maintenance;Malignant Neoplasms;Maps;Memory;Modeling;Molecular;Molecular Conformation;monomer;nanopore;Outcome;Phenotype;Population;Process;Protein Dynamics;Proteins;recruit;Repetitive Sequence;Research;Role;Satellite DNA;Series;Site;Specific qualifier value;Stretching;Technology;telomere;Testing;Variant;Work

PROJECT_TITLE: Genomic Analysis of Centromere Assembly and Function

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: Project Narrative Aneuploidy plays a major role in human health, causing debilitating developmental disorders, enabling cancer evolution, and supporting drug resistance in human pathogens. This project will study how different individuals vary in their ability to tolerate extra chromosomes, using the model eukaryote Saccharomyces cerevisiae.

PI_NAMEs: GASCH, AUDREY  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Aneuploidy;Architecture;Cells;Chromosome Mapping;Chromosome Segregation;Chromosomes;comparative genomics;cost;design;Development;developmental disease;Dissection;DNA;Down's Syndrome;Drug Metabolic Detoxication;Drug resistance;drug resistant pathogen;emerging pathogen;Eukaryota;Evolution;Expression Library;fitness;functional genomics;Gene Duplication;Genes;Genetic;genetic architecture;Genetic study;Genetic Variation;Genotype;Health;Human;Human Biology;human pathogen;Individual;Infertility;innovation;insight;Karyotype;Laboratories;Laboratory Study;Malignant Neoplasms;Mammalian Cell;Maps;Measures;Methods;Modeling;Molecular;Mutation;non-Native;Organism;overexpression;pathogenic fungus;Pharmaceutical Preparations;Phenotype;Phylogeny;Physiological;Play;Population Genetics;Precision cancer therapy;Production;Proteins;proteostasis;rare variant;Role;Saccharomyces cerevisiae;Saccharomycetales;Stress;Syndrome;System;Testing;Time;tumor;Variant;yeast genetics;Yeasts

PROJECT_TITLE: Dissecting the influence of genetic background on aneuploidy tolerance in the model eukaryote Saccharomyces cerevisiae

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Biotechnology;Complementary and Integrative Health;Genetics;Human Genome;Microbiome;Natural Products

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE The genomes of cyanobacteria and sponge-associated microbes encode numerous compounds that could provide the basis for new drugs. Discovery and development of these chemicals as drug candidates, however, is challenging due to their low availability in Nature. The proposed multidisciplinary research will address this limitation and should provide the methodology to increase the number of new natural products as starting points for drug discovery and development.

PI_NAMEs: ABOU DONIA, MOHAMED ;BRUNER, STEVEN D;DING, YOUSONG ;LUESCH, HENDRIK  (contact);PAUL, VALERIE JEAN

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Actinobacteria class;Action Research;Address;Anabolism;Antibody-drug conjugates;apratoxin;Artificial Intelligence;Bacteroidetes;bioactive natural products;Biochemistry;Biodiversity;Bioinformatics;bioinformatics tool;Biological;Biological Assay;Bioprobe;Breathing;Caenorhabditis elegans;Cell Physiology;cellular targeting;chemical synthesis;Chemicals;Collaborations;Collection;Communities;computational chemistry;coral;Coupled;CRISPR/Cas technology;Crude Extracts;Cyanobacterium;Cytology;deletion library;Development;Developmental Process;Dimensions;Disease;Dolastatin 10;drug candidate;drug development;drug discovery;Drug Targeting;Ecology;Enzymatic Biochemistry;enzyme substrate;Enzymes;Family;FDA approved;Firmicutes;fitness;Florida;Future;G-Protein-Coupled Receptors;Gene Cluster;Gene Expression Profiling;Generations;Genes;Genetic;genetic information;Genome;genome analysis;genome sequencing;Genomics;Geography;Goals;Grant;In Vitro;in vivo;in vivo Model;innovation;interdisciplinary approach;Interdisciplinary Study;Joints;Knowledge;Libraries;Light;Link;Mammalian Cell;marine;marine natural product;marine organism;member;metabolomics;metagenome;Metagenomics;Methodology;Microbe;microbial;Microbial natural product;microbiome;microorganism;Mining;Molecular;multidisciplinary;Natural Product Drug;Natural Products;Natural Products Chemistry;Natural Resources;Natural Selections;Nature;novel;novel therapeutics;Organic Chemistry;Organism;Pathway interactions;Pharmaceutical Preparations;Pharmacology;Phenotype;Phylogenetic Analysis;Physiological Processes;Porifera;Proteins;Proteobacteria;Publications;Research;Research Personnel;RNA Interference;Sampling;scaffold;screening;Skeleton;structural biology;Structure;success;synthetic biology;System;Systems Biology;Techniques;Testing;Therapeutic;Therapeutic Uses;tool;transcriptome;transcriptomics;Translating;United States National Institutes of Health;Yeasts

PROJECT_TITLE: Integrative Multidisciplinary Discovery Platform to Unlock Marine Natural Products Therapeutic Opportunities


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Nutrition;Physical Activity;Prevention

ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Preservation of mobility is one of the biggest health concerns of elderly population associated with aging. Identification of cost-effective therapies that can preserve independence and healthy mobile capacity in the elderly would have a cumulative effect, influencing many other aspects of mental and physical health in a wide population demographic. Here we propose to investigate whether the proteins named Sestrins, which are natural inhibitors of diverse age-associated diseases, can be used as a new molecular target to preserve mobile capacity and quality of life in later ages.

PI_NAMEs: KIM, MYUNGJIN ;LEE, JUN HEE  (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Age;age-related disease;Aging;Anabolism;Animal Model;Attenuated;Autophagocytosis;Binding;Biochemical;Biogenesis;Biological Assay;Branched-Chain Amino Acids;Communities;Complex;cost effective treatment;Cyclic AMP-Dependent Protein Kinases;Data;Diet;dietary;Elderly;Elements;Exercise;experimental study;Family;fly;Funding;Generations;Genetic;Genetic study;Health;Homeostasis;improved;In Vitro;in vivo;inhibitor;innovation;Intervention;Leucine;Lipids;Mediating;Medical;Mental Health;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methodology;Methods;Mitochondria;Modeling;Molecular Target;Mus;Muscle;muscle aging;muscle degeneration;Muscle Fibers;muscle form;Muscle function;Muscle Mitochondria;muscle physiology;Muscle Proteins;muscle strength;Muscular Atrophy;muscular structure;Names;novel;Nutrient;Outcome;Output;Oxidation-Reduction;Pathway interactions;Pharmaceutical Preparations;Phenotype;Phosphotransferases;physical conditioning;Physiological;Play;Population;preservation;Preventive;protein complex;Protein Kinase;protein purification;Proteins;Proto-Oncogene Proteins c-akt;Publishing;Quality of life;Regulation;Research;Role;Series;Signal Transduction;STK11 gene;Stress;System;Technology;Testing;Therapeutic;transcriptomics;ultra high resolution;Up-Regulation;Work

PROJECT_TITLE: Sestrins-mediated integration of leucine and exercise benefits for mitochondrial homeostasis

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Genetics

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY

ORG_STATE: TX

PHR: Project Narrative Cellular nanomachines called ribosomes make proteins; they begin protein synthesis at start sites and end protein synthesis at stop sites located in mRNA, which is the blueprint they use to make protein. We and others have discovered additional start and stop sites in many RNA blueprints that direct protein synthesis but which are upstream of the main start and stop sites that direct the construction of the major protein specified in the RNA blueprint. This proposed work aims to gain a precise and complete understanding of how and why an RNA blueprint tells ribosomes to use these upstream protein synthesis sites.

PI_NAMEs: SACHS, MATTHEW STEVEN (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Anabolism;Aspergillus fumigatus;biochemical tools;biophysical tools;Biotechnology;Cell Physiology;Cells;Coccidioides posadasii;Code;Coupled;Cryptococcus neoformans;Data;disorder control;Enzymes;fungus;Gene Expression;gene product;Genetic;Goals;Growth;Health;Human;improved;In Vitro;in vivo;Initiator Codon;Inositol;inositol 3-phosphate;Inositol Metabolism Pathway;insight;Knowledge;Mammalian Cell;Messenger RNA;Metabolic;Metabolic Pathway;Metabolism;Mission;model organism;Modeling;Molds;Molecular Mechanisms of Action;mRNA Transcript Degradation;mRNA Translation;Names;nanomachine;Neurospora crassa;Open Reading Frames;pathogenic fungus;Pathway interactions;Peptides;Peptidyltransferase;Physiological;Process;Production;Protein Biosynthesis;Proteins;Regulation;Regulatory Pathway;Reporter Genes;Research;Resolution;response;Ribosomes;RNA;Role;Scanning;Site;small molecule;Specific qualifier value;Structure;System;Testing;Therapeutic;Translating;Translations;United States National Institutes of Health;welfare;Work

PROJECT_TITLE: Translational control of gene expression in fungi