NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Prestin, a voltage-dependent motor portion, is found in high densities at the basolateral membrane of outer hair cells (OHCs) where it is responsible for the process of electromotility, which boosts the sense of hearing particularly at high frequencies. Understanding the structure and function of Prestin will define the molecular mechanisms underlying cochlear amplification, a process that relates directly to health and disease. This information serves, not only as key element in the most basic aspect of various cellular sensory functions OHCs but has the potential to influence the way we address late onset and high noise-derived hearing loss.

PI_NAMEs: PEROZO, EDUARDO A (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Address;Amino Acids;Amplifiers;Anions;Auditory Physiology;basolateral membrane;Behavior;Binding;Binding Sites;Biochemical;Biological;Charge;Cochlea;crosslink;Cryoelectron Microscopy;Data;data modeling;Dependence;design;Detergents;Development;Devices;Disease;Elbow;Electric Capacitance;electric field;Electrophysiology (science);Electrostatics;Elements;Elevator;Environment;Equilibrium;Event;experience;experimental study;Family;feasibility research;Fluorescence Microscopy;Frequencies;Glycine;Goals;Health;Hearing;hearing impairment;inhibitor;insight;Ion Channel;Light;Lipid Bilayers;Lipids;Mechanics;member;Membrane;Membrane Proteins;Micelles;Modeling;Molecular;Molecular Conformation;Molecular Motors;Motion;Motor;Motor Neurons;Movement;Mutagenesis;nanodisk;Nature;Noise;Outer Hair Cells;physical model;Physiological;Preparation;Process;Proteins;rat Pres protein;Reaction;reconstitution;Reproducibility;Resolution;Role;Salicylic Acids;sensor;Sensory;Series;Signal Transduction;Site;Site-Directed Mutagenesis;Structure;voltage;voltage clamp

PROJECT_TITLE: Structural basis of Outer Hair Cell Electromotility at High Resolution

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS-M]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Kidney Disease;Nutrition

ORG_CITY: CAMBRIDGE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: REVEAL PHARMA

ORG_STATE: MA

PHR: PROJECT NARRATIVE Given the well-documented risks of administering iodinated CT radiocontrast and gadolinium-based MRI contrast agents to renally impaired patients and the prevalence of heart disease renally impaired population, there is a major unmet need for new contrast media that is safe for renally impaired patients. Reveal Pharmaceuticals is developing a manganese-based MRI contrast agent (RVP-001) as safe gadolinium-free alternative (NCT05413668). The objectives of this proposal are to demonstrate that RVP-001 is functionally equivalent to Gd-based contrast agents in pig models of chronic ischemic and non-ischemic heart disease and to perform late phase clinical trial enabling toxicology studies in rats.

PI_NAMEs: HOFFMAN, VERA  (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Acute;Acute myocardial infarction;Address;Adult;Adverse event;aging population;Angiography;Animal Model;Animals;bone;Brain;Breast;Cardiac;cardiac magnetic resonance imaging;Cardiovascular Agents;Cardiovascular Diseases;Cardiovascular system;Catheterization;Cessation of life;chelation;Cholesterol;Chronic;Chronic Kidney Failure;Cicatrix;Clinic;Clinical Protocols;Clinical Trials;comorbidity;contrast enhanced;Contrast Media;coronary artery occlusion;coronary fibrosis;Deposition;design;Detection;Diabetes Mellitus;Diagnostic;Diet;Diffuse;Dose;Drug Kinetics;EFRAC;Europe;experimental study;extracellular;Extracellular Fluid;Face;Family suidae;Farm;Fatty acid glycerol esters;FDA approved;Fibrosis;Fructose;Funding;Gadolinium;General Population;Goals;Heart Diseases;heart disorder diagnosis;Heart failure;heart failure with reduced ejection fraction;heart imaging;Hepatobiliary;high risk;Human;Image;imaging properties;imaging study;Impairment;improved;Infarction;Injury to Kidney;insight;Ischemia;Kidney;Kidney Diseases;kidney dysfunction;Left;Life;Link;Magnetic Resonance Imaging;Manganese;manufacture;Marketing;Measures;Mineralocorticoids;Miniature Swine;Modeling;Morbidity - disease rate;MRI Scans;Myocardial Infarction;Myocardial Ischemia;Myocardial perfusion;National Heart, Lung, and Blood Institute;Nephrogenic Systemic Fibrosis;Obesity;Output;patient population;Patients;Pharmacologic Substance;Phase;Phase I Clinical Trials;Phase II Clinical Trials;Placebos;Play;Population;porcine model;preservation;Prevalence;Procedures;prognostic value;Radiology Specialty;rational design;Rattus;Reperfusion Therapy;Risk;Rodent;Safety;Scanning;Small Business Innovation Research Grant;Sodium Chloride;Toxicokinetics;Toxicology;Treatment Efficacy;treatment planning;United States;United States National Institutes of Health;Ventricular;Work;X-Ray Computed Tomography

PROJECT_TITLE: Manganese-based Contrast Agent for Cardiovascular MRI

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-Z(10)B]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Genetics;Liver Disease;Nutrition

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative The project aims to understand the molecular mechanisms underlying the etiology of non-alcoholic fatty liver disease (NAFLD) caused by insulin resistance. By studying the role of hepatic ceruloplasmin (CP, a copper- binding protein) and copper in lipid metabolism and the development of NAFLD, we expect to gain novel knowledge on molecular mechanisms by which insulin resistance promotes NAFLD. Our hope is to facilitate the rational design of treatments for NAFLD, the most prevalent liver disease in the US.

PI_NAMEs: MIAO, JI  (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: 5'-AMP-activated protein kinase;Address;Affect;American;Binding;Biological Assay;blood glucose regulation;Cardiovascular Diseases;cardiovascular disorder risk;Cells;Ceruloplasmin;Chelating Agents;Copper;copper-binding protein;Data;Development;Diabetes Mellitus;diabetic;diabetic patient;EP300 gene;Etiology;fatty acid oxidation;FDA approved;FOXO1A gene;Gene Expression;Genes;Genetic Transcription;Goals;Health;Hepatic;Hepatocyte;High Fat Diet;Homeostasis;Human;improved;Incidence;Individual;Insulin;Insulin Resistance;Iron Overload;knock-down;Knock-out;Knockout Mice;Knowledge;Link;lipid metabolism;Liver;Liver diseases;loss of function;Malignant neoplasm of liver;Mediating;Membrane;Metabolic;Metabolic Diseases;Molecular;mortality;mouse model;Mus;mutant;non-alcoholic fatty liver disease;novel;Obesity;overexpression;Pathologic;Pathology;Phosphotransferases;Plasma;Plasma Proteins;PPAR alpha;promoter;Protein Kinase Interaction;rational design;Regulation;Risk;Rodent;Role;Severities;Signal Transduction;STK11 gene;Structure of beta Cell of islet;Testing;therapy design;Up-Regulation;Viral;Work

PROJECT_TITLE: Copper and copper-binding proteins in insulin resistance-associated metabolic disease

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Cancer;Diabetes;Genetics

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Insulin is a potent mitogen, and hyperinsulinemia can promote and sustain tumor growth. In this R35 MIRA proposal, we will determine the function and mechanism of insulin action in chromosome stability, and investigate the structural basis and regulation of spatiotemporal insulin receptor signaling. This research will advance our understanding of a relationship between hyperinsulinemia, cancer, and diabetes, which is essential to develop novel clinical treatments for type 2 diabetes and cancer.

PI_NAMEs: CHOI, EUNHEE  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Affect;Aneuploidy;Binding;Biochemistry;cancer cell;cancer immunotherapy;Cell Differentiation process;Cell division;Cell membrane;Cell Proliferation;Cell surface;Cells;Cellular biology;Cellular Metabolic Process;Chromosomal Stability;Chromosome Segregation;Clathrin Adaptors;Clinical Treatment;Complex;CRISPR/Cas technology;Cryoelectron Microscopy;Diabetes Mellitus;Disease;Endocytosis;Ensure;extracellular;Future;Genes;genome-wide;Genomics;Goals;Growth;Growth Factor;Health;Homeostasis;Human;Hyperinsulinism;Immune;Insulin;Insulin Receptor;Insulin-Like-Growth Factor I Receptor;Investigation;Knowledge;Ligands;loss of function;Malignant Neoplasms;MAP Kinase Gene;Metabolic;Metabolism;Mitogens;Mitosis;Mitotic Checkpoint;mouse genetics;Mus;MXI1 gene;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutrient;Organism;Outcome;Pathway interactions;Physiological;PIK3CG gene;Proliferating;Proteins;Proto-Oncogene Proteins c-akt;receptor;receptor function;Receptor Mediated Signal Transduction;Receptor Protein-Tyrosine Kinases;Receptor Signaling;recruit;Regulation;Research;Risk;Role;Signal Pathway;Signal Transduction;spatiotemporal;Surface;T-Cell Lymphoma;Therapeutic;Tissues;Translational Research;tumor growth

PROJECT_TITLE: Investigation of the role of insulin receptor in chromosome stability.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ADMINISTERING_IC: DA

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Opioid use disorders are a substantial public health burden, with high rates of relapse, morbidity, and mortality, with existing treatments working for some but not all living with this addiction. This project proposes to test whether the strategic ectopic expression of a low-affinity mu opioid receptor, LAMuOR, can suppress the reward value of exogenous opioids of abuse without reacting to endogenous opioid peptides. If successful, LAMuOR could prove to be a novel translational strategy by which a single treatment would confer life-long protection from opioid use disorders.

PI_NAMEs: CLEMENZA, KELLY  (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: addiction;Affect;Affinity;Agonist;Attenuated;Behavior;Behavioral;Bilateral;Binding;Biological Assay;Biosensor;Brain;Cells;comorbidity;Coupled;Data Correlations;designer receptors exclusively activated by designer drugs;Development;Disinhibition;Dopamine;dopaminergic neuron;Ectopic Expression;effective intervention;endogenous opioids;Exhibits;Failure;Fentanyl;fentanyl self-administration;Fiber;gamma-Aminobutyric Acid;Genes;Goals;Heroin;Intervention;Ligands;Locomotion;Logic;Mediating;Mental disorders;Methods;Modality;Monitor;Morbidity - disease rate;mortality;mu opioid receptors;Mus;mutant;Mutation;Neurons;novel;novel strategies;Nucleus Accumbens;Opioid;opioid abuse;Opioid Peptide;opioid use disorder;Pathway interactions;Photometry;Physiological;prevent;Property;Public Health;Reaction;receptor;Receptor Activation;receptor expression;Receptor Inhibition;Relapse;response;Rewards;Rotation;Self Administration;Signal Transduction;Testing;Therapeutic;Therapeutic Uses;tool;Training;translational approach;treatment strategy;Variant;Ventral Tegmental Area;Viral Vector;Work

PROJECT_TITLE: Developing a Gene-Based Approach for Lasting Protection from Opioid Use Disorder


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Cardiovascular;Rare Diseases

ORG_CITY: ROCHESTER

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative – Relevance to Public health Aortic aneurysms are life-threatening diseases characterized by progressive dilatation and rupture and are a significant cause of death in aging populations. Currently, there is no effective clinical treatment to prevent aortic aneurysm expansion and rupture. The proposed study will explore the roles, pharmacological effects, and the mechanisms of action of targeting different PDE1 family enzymes in the development and progression of aortic aneurysm. The translational value of this study is highlighted by the fact that PDE1 pan inhibitors are proposed for clinical trials to treat other diseases, suggesting an urgent need to characterize the potential outcomes of targeting different PDE1 isozymes in aneurysm.

PI_NAMEs: YAN, CHEN  (contact)

PROGRAM_OFFICER_NAME: STABLEY, JOHN N

PROJECT_TERMS: Abdominal Aortic Aneurysm;Ablation;Aging;Aneurysm;Aorta;Aortic Aneurysm;Apoptosis;Attenuated;Binding Sites;Blood flow;Blood Vessels;Cause of Death;Cell Death;Cell Survival;Cells;Cessation of life;Chronic;Clinical;Clinical Treatment;Clinical Trials;Cyclic AMP;Cyclic GMP;Cyclic GMP-Dependent Protein Kinases;Cyclic Nucleotides;Data;Development;Dilatation - action;Disease;Dissection;Drug Targeting;Elasticity;Enzymes;Extracellular Matrix;Family;forkhead protein;Functional disorder;gain of function mutation;Genes;Grant;Heart;Heart failure;Human;Hypertension;In Vitro;in vivo;inhibitor;Intervention;Isoenzymes;Knock-out;Knockout Mice;Life;Link;Matrix Metalloproteinases;Medial;member;Metadata;Modeling;mortality;mouse model;Mus;novel;Nucleic Acid Regulatory Sequences;Operative Surgical Procedures;Outcome;Pathogenesis;Pathogenicity;Patients;pharmacologic;Phenotype;phosphoric diester hydrolase;Play;Population;Preparation;prevent;Production;protective effect;Protein Kinase;Public Health;Publishing;Regulation;repaired;response;Role;Rupture;Ruptured Aneurysm;Ruptured Aortic Aneurysms;Schizophrenia;senescence;Signal Transduction;single-cell RNA sequencing;Site;Smooth Muscle Myocytes;Stress;Thoracic Aortic Aneurysm;Tissues;transcriptome

PROJECT_TITLE: Role of cyclic nucleotide signaling in aortic aneurysm

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-C(02)]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The health and life sciences are in the midst of a profound revolution. The application of new technologies and quantitative approaches from engineering, computer science, and physics to the life sciences has fueled fundamental advances in molecular and cellular biology while at the same time transforming medical devices, diagnostics, and therapeutic modalities. The UCSF/UC Berkeley Graduate Training Program in Bioengineering is making a significant contribution to meeting these societal needs by training the next generation of bioengineers.

PI_NAMEs: HERNANDEZ, CHRISTOPHER JOHN (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Biomedical Engineering;Joints

PROJECT_TITLE: UCSF/UCB Joint Graduate Group in Bioengineering

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Neurological and neuropsychiatric disorders can disrupt the ability to regulate both motor responses and arousal levels during unexpected, potentially threatening, or rewarding events, leading to excessive startle reactions, defensive postural tone, and psychomotor disturbances. Increasing evidence indicates that the cerebellum can learn to suppress or enhance defensive movements and arousal levels and that cerebellar damage produces impairments in both movement and the regulation of brain state, but little is known about the brain connections that coordinate cerebellar regulation of movement and arousal. This research project will use rigorous neural circuit connectivity, electrophysiological, and behavioral techniques to identify how neurons in the cerebellum regulate motor function of the trunk, neck, and eyes together with arousal levels in response to unexpected, potentially threatening stimuli; the results will provide critical missing information for diagnosing and treating arousal dysfunction in neurological and neuropsychiatric disorders.

PI_NAMEs: DU LAC, SASCHA  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Affective;Anatomy;Animal Model;Anxiety;Arousal;awake;Basal Ganglia;Behavior;Behavioral;Brain;Brain Stem;Cell Nucleus;cell type;Cerebellar Nuclei;Cerebellar vermis structure;Cerebellum;Cerebral cortex;cholinergic;Clinical;Cognitive;Collection;Coupled;Diagnosis;Electrocorticogram;Electrophysiology (science);Event;experience;experimental study;Exposure to;Eye;Fire - disasters;Foundations;Functional disorder;genetic manipulation;Goals;Head;Human;Hypersensitivity;imaging study;Impairment;Laboratories;Learning;Limbic System;Maps;Medial;Mediating;Mental disorders;Methods;Monitor;Motor;motor control;motor symptom;Movement;multidisciplinary;Mus;Neck;Nervous System Disorder;neural circuit;Neurons;neurophysiology;neuropsychiatric disorder;new therapeutic target;non-motor symptom;noradrenergic;Nucleus fastigii;oculomotor;optogenetics;Output;Patients;pharmacologic;Physiological;Physiology;Play;Pontine structure;Positioning Attribute;postsynaptic;Posture;presynaptic;Regulation;Reporter;Research;Research Personnel;Research Project Grants;response;Rewards;Role;Sensory;sensory stimulus;Silicones;Site;Startle Reaction;Stimulus;Synapses;Techniques;Therapeutic;tool;Vestibular nucleus structure;Viral

PROJECT_TITLE: Cerebellar Fastigial Motor and Non-motor Circuits

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE Children who receive less warmth, support, and responsiveness from their parents typically have higher inflammation levels, blood pressure, and allostatic load, indicators that predict future cardiovascular problems, reduced cognitive functioning, and risk for Alzheimer’s Disease and Related Dementias (ADRD). This project examines the significance of family experiences in adolescence for physical and cognitive health outcomes in adulthood by conducting a follow-up into midlife of the Sibling Interaction and Behavior Study (SIBS), a longitudinal study of 409 adoptive and 208 non-adoptive families. The adoption design of the study allows a strong test of the hypothesis that family experiences are linked to physical health and cognitive outcomes with downstream implications for Alzheimer’s Disease and Related Dementias (ADRD) risk through environmental pathways.

PI_NAMEs: KRUEGER, ROBERT F (contact);ROISMAN, GLENN I

PROGRAM_OFFICER_NAME: HOOKER, EMILY DIANE

PROJECT_TERMS: Address;Adolescence;Adolescent;Adoption;Adult;Adult Children;adverse childhood events;Affect;Age;age related decline;Aging;allostatic load;Alzheimer's disease related dementia;Alzheimer's disease risk;behavioral study;Biological;Biological Markers;Biological Process;Blood Pressure;Buffers;Cardiovascular system;caregiving;Child;Child Rearing;Childhood;Code;Cognition;Cognitive;cognitive enhancement;cognitive function;cognitive reserve;cohort;Cohort Studies;Conflict (Psychology);Country;Data;dementia risk;design;Development;Diagnosis;Dimensions;Disease susceptibility;disorder risk;early experience;Environment;Environmental Impact;experience;Face;Family;Family Research;Family Study;follow up assessment;follow-up;Future;Generations;Genes;Genetic;Health;Health Status;Heart Diseases;Impaired cognition;Individual;Inflammation;informant;Intake;Investments;late life;Link;Literature;Longitudinal Studies;longitudinal, prospective study;Maintenance;Measures;Mediating;Metabolic syndrome;middle age;mild cognitive impairment;Mind;Modeling;offspring;older adult;Outcome;Parent-Child Relations;Parents;Participant;Pathway interactions;Phase;physical conditioning;prospective;Prospective Studies;psychosocial;Public Health;Reporting;Research;Research Design;Risk;risk variant;Science;Siblings;Skin;social;societal costs;Symptoms;systemic inflammatory response;Testing;Variant;Work

PROJECT_TITLE: Antecedents of Adult Physical Health and Cognitive Risks for Alzheimer's Disease and Related Dementias (ADRD) in Adolescent Family Experiences: A Prospective, Longitudinal Adoption Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-P(02)]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Dental, Oral, and Craniofacial Disease;Genetics

ORG_DEPT: DENTISTRY

PHR: Recent advancements in the understanding of regulation of bone remodeling, specifically through TGFβ-induced osteocyte perilacunar/canalicular remodeling (PLR) offer new insight into the maintenance of bone quality. This project seeks to elucidate the role of miRs in modulating TGFβ-mediated PLR and mitochondrial function, and whether these molecular processes may be leveraged to treat bone-remodeling defects. Understanding these molecular mechanisms in osteocytes may identify novel therapeutic targets to modulate bone remodeling and rescue bone quality defects.

PI_NAMEs: YOON, JIHEE  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Acids;Biological Process;bone;Bone Diseases;bone fracture repair;bone mass;Bone Matrix;bone quality;Bone remodeling;candidate identification;Cell Physiology;Cells;Complex;Coupled;craniofacial;Data;Defect;Deposition;Development;differential expression;Disease;fracture risk;gene network;Genes;Goals;Health;Histology;Homeostasis;in silico;in vitro Assay;in vivo;innovation;insight;Knockout Mice;Maintenance;Mediating;Metabolic;Metabolic Bone Diseases;Metabolism;microCT;MicroRNAs;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;mouse model;Mus;new therapeutic target;novel;novel therapeutics;Oranges;Osteoblasts;Osteoclasts;Osteocytes;osteogenic;overexpression;Pathway interactions;Peptide Hydrolases;Play;Post-Transcriptional Regulation;prevent;Process;Property;Publishing;Regulation;Regulator Genes;Repression;Role;Series;Signal Transduction;skeletal disorder;Skeleton;Solid;Testing;Tissues;TNFSF11 gene;transcriptome sequencing;Transforming Growth Factor beta;Untranslated RNA;Work

PROJECT_TITLE: microRNA regulation of osteocyte metabolism in bone remodeling

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine

ORG_CITY: Boulder

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: Narrative Myocardial infarction (MI) and the progression to heart failure is a major public health concern that puts a large economic burden on the healthcare system. We propose an innovative approach to treat patients after an MI, where injectable biomaterials are injected into the heart early after MI to provide mechanical and biological signals that can improve the healing response. We evaluate our approach in a clinically-relevant animal model of MI, which if successful represents a translational therapy that could impact the welfare of many patients.

PI_NAMEs: BURDICK, JASON A (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: Acceleration;Acute;Advanced Development;adverse outcome;Alginates;angiogenesis;Animal Model;Area;Attenuated;Biochemical;Biocompatible Materials;Biological;Biological Process;biomaterial development;Biomedical Engineering;Biophysics;Blood Vessels;Cardiac;Cardiac Myocytes;cardiac repair;Cause of Death;Cell Communication;Cells;chemokine;Chemotactic Factors;Clinical;Clinical Trials;clinically relevant;Collaborations;Collagen;density;Deposition;design;Development;Dilatation - action;Economic Burden;Encapsulated;Endothelial Cells;Engineering;Exhibits;experience;Extracellular Matrix;fabrication;Family suidae;functional improvement;Gel;Germ Cells;healing;Healthcare Systems;Heart;Heart failure;heart function;Histologic;Hyaluronic Acid;Hydrogels;Immune;improved;improved outcome;In Vitro;in vivo;Infarction;Infiltration;inflammatory modulation;Inflammatory Response;Injectable;Injections;innovation;Intensive Care;interstitial;Invaded;Ischemia;Left Ventricular Remodeling;Left ventricular structure;Mechanics;Microfluidic Microchips;Microfluidics;Modeling;Myocardial;Myocardial Infarction;Myocardial Reperfusion;Myocardium;Myofibroblast;Natural regeneration;Nature;novel;Outcome;particle;Particle Size;Patient-Focused Outcomes;Patients;Peptide Hydrolases;Phase;Phenotype;Polymers;Population;Porosity;preservation;Process;Property;Public Health;Rattus;Readiness;recruit;regenerative;repaired;Reperfusion Injury;Reperfusion Therapy;Reporting;response;Rodent;Role;safety and feasibility;scale up;Signal Transduction;Silicon;Stress;Stromal Cells;Structure;Supporting Cell;Surgeon;Technology;Testing;Therapeutic Effect;Thinness;Tissue Harvesting;tissue repair;Tissue Viability;Tissues;translational potential;translational therapeutics;Translations;United States;welfare;Work

PROJECT_TITLE: Engineered Granular Hydrogels for Endogenous Tissue Repair

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: MIAMI

ORG_NAME: JORVEC CORPORATION

ORG_STATE: FL

PHR: Pattern Electroretinography (PERG) is an important indicator of Retinal Ganglion Cell (RGC) health, and can be used to monitor the progression of degenerative retinal diseases such as glaucoma. The implementation of the proposed PERG device and analysis methods is expected to increase the accessibility of detection systems both clinically and in research. The improved stimulator and analysis techniques are expected to increase the diagnostic value of the PERG response by increasing the quality and quantity of diagnostic measures. As such, the proposed work will greatly impact public health by improving screening measures for glaucoma and potentially other retinal disorders.

PI_NAMEs: TOFT-NIELSEN, JONATHON ANTHONY (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: Adoption;Affect;Age;Algorithms;Blindness;body position;Cell Death;Cell Physiology;Cessation of life;Characteristics;Clinical;clinical application;Clinical Management;clinically relevant;Communities;Computer software;cost;Data;Dependence;Detection;detection platform;Development;Devices;Diagnostic;diagnostic value;Disease;Dryness;Early Diagnosis;Electrodes;Electroretinography;Environment;Exhibits;Experimental Models;experimental study;Eye;Foundations;Functional disorder;functional loss;Glaucoma;Goals;Head;Health;Human;human model;human subject;improved;in vivo;Individual;innovation;Investigation;Left;light weight;Measures;Methods;miniaturize;Monitor;Neuroanatomy;neurophysiology;next generation;Noise;novel;operation;optic nerve disorder;Optical Coherence Tomography;Optics;Patients;Pattern;Performance;Perimetry;Phase;Physiologic Intraocular Pressure;Population;portability;Posture;Preparation;prevent;prototype;Public Health;Pupil;Research;Research Personnel;response;Response to stimulus physiology;Retina;retinal damage;Retinal Degeneration;Retinal Diseases;retinal ganglion cell degeneration;Retinal Ganglion Cells;ROC Curve;sample fixation;Scientist;screening;Sensitivity and Specificity;Signal Transduction;Specificity;Standardization;Stimulus;Stress;Suspect Glaucomas;System;Techniques;Technology;Testing;Therapeutic;Time;tool;Uncertainty;user-friendly;Vision research;Visual;Visual Fields;visual tracking;Visualization;Work

PROJECT_TITLE: Advanced CLAD PERG system with minimal patient preparation for clinical settings (Phase II)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-M(12)B]


NIH_SPENDING_CATS: Biotechnology;Diabetes;Genetics;Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PORTLAND

ORG_NAME: MAINEHEALTH

ORG_STATE: ME

PHR: The rapid increase in obesity is a major economic burden on our healthcare system. Current therapies available to fight complications associated with obesity are insufficient, costly and entail risks. Our research aims to understand how fat tissue burns energy to reveal new therapeutic avenues directed at reversal of obesity-related diseases such as type 2 diabetes, stroke and heart disease.

PI_NAMEs: BROWN, AARON CLIFFORD (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Ablation;adipocyte differentiation;Adipocytes;adipose derived stem cell;Adipose tissue;Alleles;Autophagocytosis;Biogenesis;Biological Assay;blood glucose regulation;Body Temperature;Body Weight decreased;Burn injury;Cardiovascular Diseases;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;comorbidity;cost;Data;Diet;diet-induced obesity;Disease;dosage;Economic Burden;Electron Transport;energy balance;Energy Metabolism;Excision;exosome;Fatty acid glycerol esters;fighting;Genes;Genetic;Genus Hippocampus;Goals;Healthcare Systems;Heart Diseases;High Fat Diet;Homeostasis;Homologous Gene;Human;human induced pluripotent stem cells;Hypertrophy;Impairment;improved;In Vitro;in vivo;Inflammation;inhibitor;Intervention;Knock-out;Link;lipid biosynthesis;Lipids;Measures;Mediating;Metabolic;Metabolic dysfunction;Metabolism;MicroRNAs;Mitochondria;Mitochondrial Proteins;Modeling;Molecular;mouse model;Mus;Mutant Strains Mice;nanoparticle;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Obesity;Obesity associated disease;obesity development;Obesity Epidemic;overexpression;paralogous gene;Pathway interactions;Phenocopy;Phenotype;Polyribosomes;Process;Production;Public Health;Regulation;Reporter;Research;Resistance;Respiration;response;Rewarming;Risk;Role;stem cell differentiation;Stimulus;Stroke;System;Technology;Temperature;Testing;Therapeutic;therapy development;Thermogenesis;Tissues;tool;transcription factor;Up-Regulation;Weight Gain;Weight maintenance regimen

PROJECT_TITLE: miR-27 mediated regulation of mitochondrial function in thermogenic adipocytes

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: MISSISSIPPI STATE

ORG_DEPT: CHEMISTRY

ORG_NAME: MISSISSIPPI STATE UNIVERSITY

ORG_STATE: MS

PHR: PROJECT NARRATIVE Voltage gated sodium channels are essential for action potentials in excitable cells located throughout the body (central nervous system, smooth muscle, heart and skeletal muscle), and loss of, improper, or untimely function, can each cause or contribute to disease. There has been much controversy regarding the mechanism and interpretation of data for calcium modification of sodium channel gating due to: (1) the approaches used for investigation, and (2) knowledge gaps that arise from a lack of: (i) data describing the kinetic rate of the calmodulin interactions, and (ii) investigating calmodulin function in the presence of calcium transients. This proposal will uniquely combine structural biology, stopped-flow kinetics, and electrophysiology to dissect the precise roles of the calmodulin interactions in excitable cells, and it will then explore if we can alter the kinetics of these interactions with a small molecule probe; which could give rise to a novel treatment strategy for certain types of sodium channelopathies.

PI_NAMEs: JOHNSON, CHRISTOPHER N. (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Action Potentials;Address;Affinity;Binding;Binding Proteins;Binding Sites;Calcium;Calmodulin;Cells;Central Nervous System;Complex;Conflict (Psychology);Data;Data Analyses;Disease;Electrophysiology (science);Engineering;Genes;Impairment;Individual;Investigation;Ion Channel Gating;Kinetics;Knowledge;Life;Literature;Measures;Modeling;Modification;Molecular Conformation;Mutation;Myocardium;novel;novel strategies;outcome disparities;Paper;Physiological;Physiology;Point Mutation;Process;Protein Isoforms;Proteins;Recovery;Regulation;Reporting;Research Personnel;Role;Skeletal Muscle;small molecule;Smooth Muscle;Sodium;Sodium Channel;structural biology;Structure;Testing;Time;treatment strategy;voltage;Work

PROJECT_TITLE: Calcium modification of voltage gated sodium channels

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-G(07)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Genetics;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: RICHMOND

ORG_DEPT: PSYCHIATRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative: Opiate and stimulant addictions remain significant public health problems worldwide. Despite revolutionary advances in our understanding of their neurobiological basis, much remains to be learned about different etiological factors underlying addiction heterogeneity. We have identified a unique cohort of substance users characterized by predominantly monosubstance-dependent patterns of opiate and stimulant use and by protracted abstinence, which may help decipher some of the neurobiological risk factors associated with different types of addiction.

PI_NAMEs: VASSILEVA, JASMIN L (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Abstinence;addiction;Address;alcohol use disorder;Amphetamine Users;Amphetamines;Amygdaloid structure;Back;Balkans;Behavioral;Biological Models;biotypes;Brain;brain based;Bulgaria;Classification;Clinical;Clinical assessments;clinical phenotype;Cognitive;cohort;Collaborations;computer framework;Computing Methodologies;Corpus striatum structure;Country;Data;Development;Dimensions;emotion dysregulation;Emotional;Emotions;Enrollment;Etiology;European;Executive Dysfunction;executive function;Face;financial incentive;Functional Magnetic Resonance Imaging;Genetic;Genotype;Geography;Heroin;Heroin Users;Heterogeneity;heuristics;Impulsivity;incentive salience;indexing;Individual;instrument;Joints;Laboratories;Learning;Length;Link;Machine Learning;Maintenance;Mental disorders;Modeling;multidisciplinary;multimodal data;neural circuit;neurobehavioral;Neurobiology;Neurocognitive;neuroimaging;neuropsychiatric disorder;Neurosciences;Opiate Addiction;opioid use;opioid use disorder;opioid user;Parents;Participant;Pattern;Personality;personalized intervention;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;polygenic risk score;Population;Positioning Attribute;Production;programs;Psychometrics;Public Health;Research;Research Domain Criteria;Rest;reward anticipation;Risk;Risk Behaviors;Risk Factors;Route;segregation;Siblings;Stimulant;stimulant dependence;stimulant use;stimulant use disorder;stimulant user;Substance Use Disorder;substance user;Taxonomy;Testing;theories;therapy development;trafficking

PROJECT_TITLE: Varieties of Impulsivity in Opiate and Stimulant Users


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE This proposed study aims to develop kinetically assembled biodegradable poly(beta-amino ester)/mRNA nanoparticles (KaNPs) specifically engineered to target circulating monocytes for the purpose of enhance tumor- specific immune response. If successful, this study will deliver a more potent mRNA-based immunotherapies for treatment of solid tumors and metastatic cancers.

PI_NAMEs: GREEN, JORDAN ;MAO, HAI-QUAN  (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Adjuvant;Advanced Malignant Neoplasm;Animal Model;anti-tumor immune response;Antigen-Presenting Cells;Antigens;Antitumor Response;Biodistribution;biomaterial compatibility;Bone Marrow;cancer immunotherapy;Cancer Vaccines;Cells;Chemical Structure;Chemistry;Circulation;combinatorial;COVID-19 vaccine;Deposition;design;Disseminated Malignant Neoplasm;Dose;Drug Kinetics;efficacy validation;Engineering;Esters;experience;Formulation;Freeze Drying;gene therapy;Generations;Homing;Immune;immune activation;Immune checkpoint inhibitor;Immune response;Immune system;Immunologic Adjuvants;Immunotherapeutic agent;improved;in vivo;Infiltration;innovation;intravenous injection;Kinetics;Ligands;lymph nodes;manufacturing scale-up;Mediating;Melanoma;Messenger RNA;Methodology;Methods;Modeling;monocyte;mouse model;mRNA delivery;mRNA immunotherapy;Mus;nanomedicine;nanoparticle;nanoparticle delivery;neoantigens;Patients;Peripheral;plasmid DNA;polycation;Polymers;Population;Procedures;Production;programs;Property;rational design;Reporter;response;RNA vaccine;Role;Safety;secondary lymphoid organ;Solid Neoplasm;Spleen;Standardization;STING agonists;Structure-Activity Relationship;success;Surface;T-Cell Activation;targeted delivery;Testing;therapeutic target;Time;Tissues;trafficking;Training;Transfection;Treatment Efficacy;tumor;Tumor Antigens;tumor growth;tumor microenvironment;Tumor Tissue;vaccine platform;Vaccines

PROJECT_TITLE: Kinetic Assembly of Polymer-mRNA Nanoparticles Targets Circulating Monocytes to Enhance Cancer Immunotherapy

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ADMINISTERING_IC: TR

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Clinical Research

ORG_DEPT: BIOLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: The Rockefeller University Center for Clinical and Translational Science is dedicated to improving  human health by providing resources and personnel to support the conduct of the highest quality  research to improve the prevention, diagnosis, and treatment of human disease, as well as to inform  and implement public health policy. It will also produce novel methods to improve both the  scientific information obtained in the studies and the way in which the research is performed.

PI_NAMEs: COLLER, BARRY  (contact);KRUEGER, JAMES G

PROGRAM_OFFICER_NAME: MERCHANT, CAROL

PROJECT_TERMS: Address;Affect;Area;Bioethics;Biotechnology;career;Cessation of life;Clinical;clinical center;clinical investigation;Clinical Investigator;Clinical Nursing Research;Clinical Research;Clinical Sciences;Collaborations;Communities;community engagement;Competence;Complex;Consultations;Creativeness;Data;Dedications;design;Development;Diagnosis;Disease;DNA sequencing;Education;Elements;empowerment;Enrollment;Ensure;Environment;Evaluation;experience;Formulation;Funding;Genome;Grant;Health;Health Policy;high standard;Hospitals;Human;human disease;Human Resources;Immunocompetence;improved;Individual;Informed Consent;Infrastructure;innovation;Institution;Knowledge;Laboratories;Leadership;Medical;Medicine;Methods;Modeling;Modification;Monitor;monoclonal antibody production;multidisciplinary;Neighborhood Health Center;New York;next generation;novel;novel therapeutics;Nurses;Nursing Research;older adult;Outcome;outreach;Participant;participant enrollment;participant safety;Patients;Pennsylvania;pharmacokinetics and pharmacodynamics;Pharmacy facility;Phase;Policies;Population;practice-based research network;Prevention;programs;Public Health;Publications;recruit;Reporting;Reproducibility;Research;Research Design;Research Personnel;Resources;Scholars Program;Science;Scientist;skills;Special Population;Speed;success;Surveys;therapeutic development;Time;Training;Translational Research;translational scientist;Translations;Universities;Vision

PROJECT_TITLE: Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Genetics;Women's Health Research

ORG_CITY: GREENSBORO

ORG_NAME: NORTH CAROLINA AGRI & TECH ST UNIV

ORG_STATE: NC

PHR: PROJECT NARRATIVE The proposed project is relevant to public health because it will result in a series of preliminary data that will inform future grant applications that aim to develop inexpensive and fast molecular robots to diagnose and treat diseases. The proposed robot will detect breast cancer microRNAs and regulate the expression of select genes that serve as therapeutic agents. If successful, the robot enables more convenient means of theranostics, and since RNA molecules are linked to many diseases, the robot has a broader reach than cancer medicine.

PI_NAMEs: ZADEGAN, REZA  (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Advocate;Applications Grants;Biological Markers;biophysical tools;Biopsy;Breast Cancer Cell;Breast Cancer Detection;cancer biomarkers;cancer cell;Cellular biology;chemotherapy;clinical diagnostics;Collaborations;Communities;Consumption;Cost Allocation;Data;design;Detection;Diagnosis;Diagnostic;diagnostic platform;Diagnostic Procedure;digital;Disease;disease diagnosis;DNA;DNA-Directed RNA Polymerase;Engineering;Equipment;feasibility research;Foundations;Future;gel electrophoresis;Gene Expression;gene product;Genes;Genetic Transcription;Goals;Grant;Green Fluorescent Proteins;high volume manufacturing;Image;Immunotherapy;improved;In Vitro;interest;Life;Link;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Medical;Medical Device;Medicine;Mentorship;Methods;MicroRNAs;Mission;Molecular;Molecular Biology;Molecular Machines;Monitor;Nanotechnology;Operative Surgical Procedures;Optics;overexpression;Pathway interactions;Patients;Performance;Polymerase Chain Reaction;Positioning Attribute;Procedures;Property;prospective;Protein Biosynthesis;Proteins;prototype;Public Health;Qualifying;Radiation therapy;Reaction;reaction rate;Reaction Time;repaired;Research;Research Activity;Resource Allocation;Resources;response;RNA;Robot;Roentgen Rays;Scientist;self assembly;Series;Signal Transduction;Specificity;student training;Students;synthetic biology;Testing;theranostics;Therapeutic;Therapeutic Agents;therapeutic gene;Therapeutic procedure;Time;tool;Training;Training Activity;translational research program;Ultrasonography;United States National Institutes of Health;Work;X-Ray Computed Tomography

PROJECT_TITLE: Developing DNA-Based Molecular Robots


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

PHR: Impairments in cognitive flexibility are a hallmark of many psychiatric and neurological disorders including schizophrenia, attention deficit/hyperactivity disorder, addiction, Alzheimer’s and Parkinson’s disease, where these deficits have been linked to functional outcome. A convergence of evidence across species indicates that GABAergic interneurons in the prefrontal cortex support cognitive flexibility in both humans and mice. This application investigates how this occurs in the adult, as well as developmental time periods and mechanisms enabling prefrontal GABAergic interneurons to properly wire into prefrontal cortical circuitry, to support the emergence of normal prefrontal network function and cognitive flexibility in adulthood.

PI_NAMEs: CANETTA, SARAH E (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Acute;addiction;Address;Adolescence;Adult;Affect;Alzheimer's Disease;Anatomy;Attention;Attention deficit hyperactivity disorder;Behavior;Behavioral;behavioral outcome;cell type;Cells;Cognition;Cognitive;cognitive ability;Cognitive deficits;cognitive process;D Cells;Data;designer receptors exclusively activated by designer drugs;Development;Dimensions;early adolescence;executive function;flexibility;Frequencies;Fright;Functional disorder;functional outcomes;gamma-Aminobutyric Acid;Genetic;Human;Impairment;Infant;insight;Interneurons;Knowledge;Learning;Link;Measures;Mental disorders;Molecular;Monitor;Mus;Nervous System Disorder;Neurobiology;Neurons;neuropsychiatric disorder;optogenetics;Outcome Assessment;Output;Parkinson Disease;Parvalbumins;Performance;Phosphorus 32;Physiological;Physiology;postnatal;postnatal development;Prefrontal Cortex;programs;Puberty;Pyramidal Cells;receptor;Rodent;Role;Schizophrenia;Somatostatin;Source;Synapses;System;Testing;theories;Time;Work

PROJECT_TITLE: Sensitive periods for interneuron development supporting cognitive flexibility

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on developing new technologies for the investigation of tissue development and disease such as Alzheimer's disease, personalized medicine, and drug screening. This study will yield a soft, multifunctional electronic/microfluidic hybrid platform in 3D geometries for online monitoring, regulation, and vascularization of human organoids produced by three-dimensional (3D) cultures of tissue-resident-adult stem cells or pluripotent stem cells.

PI_NAMEs: WANG, XUEJU  (contact)

PROGRAM_OFFICER_NAME: FALCONE, JESSICA

PROJECT_TERMS: 3-Dimensional;adult stem cell;Alzheimer's Disease;Award;Behavior;Biochemical;bioelectronics;Biological;Biological Models;biomaterial compatibility;Biomimetics;Biosensing Techniques;Blood Vessels;Body System;Brain;Brain Mapping;Cells;cerebral vascularization;Characteristics;Collaborations;Communities;Culture Media;density;design;Development;Devices;Dimensions;Disease;Drug Screening;Drug toxicity;Electric Stimulation;Electronics;Electrophysiology (science);Evaluation;flexibility;Geometry;Goals;Heart;Heterogeneity;Human;human induced pluripotent stem cells;Hybrids;improved;In Vitro;in vivo;induced pluripotent stem cell;innovation;interest;Investigation;Kidney;life span;Light;light emission;lithography;Location;Lung;Measurement;Mechanics;Microelectrodes;Microfluidics;miniaturize;Monitor;multi-electrode arrays;multidisciplinary;multimodality;nanofabrication;National Institute of Biomedical Imaging and Bioengineering;Nervous System Disorder;neural patterning;neural stimulation;neurodevelopment;Neurosciences;Neurosciences Research;new technology;nutrition;Online Systems;Optics;optogenetics;Organogenesis;Organoids;Oxygen;Pattern;Performance;personalized medicine;pharmacologic;Pluripotent Stem Cells;polydimethylsiloxane;Porosity;prevent;Property;Public Health;Reaction Time;Regenerative Medicine;Regulation;Research;Resolution;Route;sensor;small molecule;spatiotemporal;Structure;Surface;System;Systems Integration;Techniques;Thinness;tissue culture;Tissue Engineering;Tissue Model;Tissues;two-dimensional;Vascularization;Work

PROJECT_TITLE: Multifunctional 3D Bioelectronic and Microfluidic Hybrid Systems for Online Monitoring, Regulation, and Vascularization of Organoids

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: LM

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD)

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE Data-driven research enables innovation across the whole spectrum of healthcare, ranging from the understanding of molecular processes for the development of better drug treatments to the design of new approaches for clinical care. The goal of the proposed program is to train future independent researchers who will be leaders across this spectrum. Through rigorous scientiﬁc training, the program will prepare them to integrate, interpret, and act on large-scale, high-throughput, and complex data resulting from biomedical research and the practice of medicine.

PI_NAMEs: GEHLENBORG, NILS  (contact)

PROGRAM_OFFICER_NAME: BINGHAM, CLAYTON SCOTT

PROJECT_TERMS: Area;Artificial Intelligence;Bioinformatics;biomedical informatics;Biomedical Research;Boston;Cancer Center;Clinical Data;clinical decision support;Clinical Informatics;Clinical Research;complex data;Data;Data Science;data visualization;Discipline;Disease;Doctor of Philosophy;driving force;Education;Enrollment;Environment;Environmental Exposure;Faculty;Funding;Future;General Hospitals;Genetic;Genotype;Grant;Health;Health system;Healthcare;Home;Hospitals;Individual;Informatics;Infrastructure;innovation;Institution;International;Israel;Knowledge;Laboratory Research;Learning;Massachusetts;Medical center;medical schools;Medicine;member;microbial genomics;Pediatric Hospitals;Phenotype;Postdoctoral Fellow;pre-doctoral;Process;programs;Public Health Informatics;Research;Research Project Grants;Research Training;statistics;Taxonomy;Teaching Hospitals;Training;Training Programs;United States National Library of Medicine;Woman

PROJECT_TITLE: Biomedical Informatics and Data Science Research Training Program (BIRT)


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Genetics

ORG_CITY: Aurora

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE The large double stranded DNA viruses, including herpesviruses and many bacteriophages which are directly responsible for antibiotic drug resistance, bacterial evolution and the ecology of the human microbiome, package their DNA into a capsid shell using a terminase enzyme. We propose studies designed to probe the essential features of genome packaging in these viruses, many of which play major roles in human health, morbidity and mortality. The results of this research will provide a better understanding of virus development a may reveal new targets for novel anti-viral therapeutics.

PI_NAMEs: CATALANO, CARLOS ENRIQUE (contact);MORAIS, MARC ;SMITH, DOUGLAS E

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Address;Anti-viral Agents;Antibiotic Resistance;ATP Hydrolysis;Bacteriophages;Binding;Biochemical;Biological Assay;Biology;biophysical techniques;Biophysics;Capsid;Catalytic Domain;Cell Physiology;Cellular biology;Complement;Complex;density;design;Dissection;DNA;DNA biosynthesis;DNA Packaging;Double Stranded DNA Virus;Ecology;Enzyme Kinetics;Enzymes;Event;Evolution;experimental study;Genetic Transcription;Genome;Health;Herpesviridae;Human;Human Microbiome;Individual;Length;Mediating;Modeling;Molecular;Molecular Conformation;molecular dynamics;Monitor;Morbidity - disease rate;mortality;Motor;novel;nuclease;Nucleocapsid;Nucleoproteins;Nucleotides;Pathway interactions;Play;Process;Protein Biosynthesis;Proteins;Reaction;Research;Research Design;Role;sensor;Series;Signal Transduction;single molecule;Site;Structure;System;Tail;terminase;Testing;translocase;viral DNA;Viral Genome;Viral Packaging;virology;Virus;Virus Assembly;virus development

PROJECT_TITLE: Structure and Function of Essential Nucleoprotein Complexes Along a Viral Genome Packaging Pathway

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: We propose to investigate FMR1 mis-splicing and restoration of FMRP in Fragile X Syndrome. Our rescue of mis-splicing and restoration of FMRP by antisense oligonucleotides (ASOs) represents a paradigm shift in the potential treatment of this neurodevelopmental disorder.

PI_NAMEs: RICHTER, JOEL D (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: 5' Untranslated Regions;Age;Amino Acids;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;autism spectrum disorder;Autopsy;Binding Sites;Biological Markers;Brain;Cell Line;Cells;CGG repeat;CpG Islands;Cytosine;Data;deep sequencing;demethylation;Developmental Delay Disorders;Disease;Drug Kinetics;efficacy evaluation;Enhancers;Event;Exons;FDA approved;FMR1 gene;Fragile X Syndrome;gene product;Gene Silencing;Genes;Genetic Transcription;Glutamates;Hippocampus;Human;Impairment;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Inherited;Injections;Innovative Therapy;Intellectual impairment;Introns;Length;Leukocytes;Methylation;Mitochondria;Mosaicism;Mus;Mutation;Nature;Neurodevelopmental Disorder;Neurons;novel therapeutics;nucleoside analog;Peptides;Poly A;polypeptide;Positioning Attribute;prevent;Protein Biosynthesis;Regimen;restoration;Ribonuclease H;RNA;RNA Splicing;Sampling;Spinal Muscular Atrophy;Testing;Therapeutic;Therapeutic Agents;Toxic effect;Transfection;Triplet Multiple Birth;Up-Regulation;Vertebral column

PROJECT_TITLE: Therapeutic Potential of Rescued FMR1 Mis-Splicing in Fragile X Syndrome

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Narrative Most genetic effects that impact gene regulation and complex traits act in trans, but very little is known about trans-genetic effects, largely due to the difficulty in detecting trans-QTLs. We propose to develop powerful methods to generate high-quality, comprehensive maps of trans-QTLs in multiple human tissues. We will use these maps to understand the molecular mechanisms of trans gene regulation and to identify new disease genes.

PI_NAMEs: LIU, XUANYAO  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Address;Affect;causal variant;cell type;Complex;Disease;disorder risk;Distant;Gene Expression;Gene Expression Regulation;gene network;Genes;Genetic;Genetic study;genome wide association study;genomic locus;Grant;human tissue;Link;Maps;Methods;Molecular;novel;Pathway interactions;Play;Quantitative Trait Loci;Regulation;Role;Statistical Methods;trait;Transgenes;Untranslated RNA;Variant

PROJECT_TITLE: Statistical Methods to Study the Genetic Basis and Mechanisms of Trans Gene Regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Cancer;Genetics;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Ewing sarcoma and other Ewing family tumors are poorly treatable bone and soft tissue cancers diagnosed predominantly in children and young adults. This project is relevant to public health, because it aims to develop selective chemotherapeutics to treat Ewing sarcoma through investigating oncogenic mechanisms of the causative agent of Ewing sarcoma, transcription factor EWS-FLI1. This mechanistic inquiry will be complemented by pharmacological studies and aid the development of selective anti-Ewing sarcoma therapeutics.

PI_NAMEs: LEGGAS, MARKOS ;ROHR, JURGEN T;TSODIKOV, OLEG V (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Affect;analog;Animal Model;antagonist;Anti-tumor Natural Products;Antineoplastic Agents;Binding;Biochemical;Biological;Biological Assay;Biophysics;Bone Tissue;cancer cell;cancer diagnosis;Cell model;Cells;Child;Childhood;Clinical;Clinical Treatment;Clinical Trials;Collaborations;Combined Modality Therapy;Complex;Crystallography;cytotoxic;cytotoxicity;Data;Derivation procedure;design;Development;DNA;DNA Binding;DNA Binding Domain;DNA Sequence;drug candidate;drug clearance;Drug Design;Drug Kinetics;effective therapy;Elements;Enhancers;Evaluation;Ewings sarcoma;EWS-FLI1 fusion protein;experience;Family;FLI1 gene;Foundations;Genetic Transcription;Goals;Higher Order Chromatin Structure;Human;improved;In Vitro;inhibitor;insight;Investigational Therapies;Kinetics;lead candidate;Liver;Malignant Bone Neoplasm;Metabolism;Microsatellite Repeats;Modeling;Molecular;Molecular Biology;Molecular Structure;mouse model;Mus;Natural Products;neoplastic cell;novel;Oncogenic;patient derived xenograft model;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacology;Pharmacology Study;Phase I/II Clinical Trial;Plasma;Plicamycin;Preclinical Testing;programs;Property;Proteins;Public Health;Reporter;Reporting;resilience;Route;Satellite DNA;screening;Shunt Device;Side;Site;soft tissue;Specificity;Structure;Testing;Therapeutic;Toxic effect;transcription factor;transcriptional reprogramming;Translating;Tube;tumor;tumorigenesis;X-Ray Crystallography;Xenograft Model;young adult

PROJECT_TITLE: Mechanistic and pharmacologic studies of selective mithramycin analogues targeting EWS-FLI1 in Ewing sarcoma

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Influenza is a major cause of death in the US and evidence suggests that some patients die from overwhelming lack of ability to mount an anti-viral response, making people prone to severe lung injury. We have discovered a new model that may explain how the influenza virus first rapidly causes loss of a key receptor, called the interferon lamda receptor. We also discovered at the molecular level how the lung recovers to increase levels of this receptor. This discovery fulfills an unmet need in this critical illness.

PI_NAMEs: MALLAMPALLI, RAMA K (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: 26S proteasome;3' Untranslated Regions;Alveolar Macrophages;antagonist;Anti-viral Response;Area;Bacterial Pneumonia;Biology;Cartoons;Cause of Death;Cessation of life;Critical Illness;Cytoprotection;Data;Disease;Disparate;Economic Burden;Foundations;Genes;Genetic Models;Genetic Transcription;Host Defense;Host Defense Mechanism;Human;Immune response;Impairment;improved;In Vitro;in vivo;Infection;Inflammatory;Influenza;influenza infection;influenzavirus;inhibitor;Injury;insight;Interferon Type II;Interferons;Lung;lung injury;Macrophage;Mediating;Messenger RNA;MicroRNAs;Modeling;Molecular;molecular modeling;monocyte;mRNA Stability;mRNA Transcript Degradation;Mus;novel;pathogen;Pathogenesis;Pathway interactions;Patients;Persons;Phase;Pneumonia;posttranscriptional;prevent;protein degradation;Proteins;receptor;receptor expression;Receptor Gene;Regulation;Resolution;response;Role;Signal Transduction;therapeutic target;Transcript;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;United States;Up-Regulation;Viral;Viral Genes;Viral Load result;Virulent;Virus;Virus Diseases;Virus Receptors;Virus Replication

PROJECT_TITLE: Regulation of the interferon lamda receptor by influenza

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BIRMINGHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: NARRATIVE The molecular mechanisms of triggering receptor expressed on myeloid cells 2 (TREM2) in Alzheimer’s disease (AD) remain not fully understood, in part due to the lack of conclusive identities for TREM2’s endogenous ligands and the lack of a good understanding of how different endogenous ligands interact with TREM2 to affect TREM2 function. The central hypothesis is that AD- associated variants at TREM2 basic site allosterically regulate endogenous ligands bound at the hydrophobic site of TREM2, and allosteric co-stimulation by endogenous ligands at both basic and hydrophobic binding sites could enhance TREM2 immune activity in AD. New knowledge gained from this study will unveil the molecular mechanism of TREM2 interactions with endogenous ligands and could have high impact for AD research and treatment by opening an unrecognized avenue of targeting both TREM2 basic and hydrophobic sites to identify TREM2’s endogenous ligands and to promote TREM2-regulated immune activation for AD treatment.

PI_NAMEs: SONG, YUHUA  (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Affect;Affinity;Allosteric Site;Alzheimer's Disease;Alzheimer's disease pathology;Amino Acids;Antibodies;Apolipoprotein E;apolipoprotein E-2;Apoptotic;Binding;Binding Sites;Biological;Biophysics;Brain;CCL4 gene;cell injury;Cell Lineage;Cell surface;Cells;Clinical Trials;Combination Drug Therapy;Compensation;Complementarity Determining Regions;Development;Disease;Docking;Electrostatics;Etiology;Excision;experimental study;Free Energy;genetic risk factor;genome wide association study;genome-wide analysis;Human;Hydrophobicity;Immune;immune activation;Immune response;Impairment;in silico;Inflammatory;Innate Immune Response;innovation;insight;Interferometry;Knowledge;Late Onset Alzheimer Disease;Ligand Binding;Ligands;Lipids;Mediating;Membrane;Methods;Microglia;Molecular;Molecular Conformation;molecular dynamics;Myelogenous;Neurodegenerative Disorders;novel;novel therapeutic intervention;Outcomes Research;Pathogenesis;Phagocytosis;Phosphatidylserines;polyanion;programs;receptor;recruit;repaired;Research;response;Signal Transduction;Site;small molecule;Structure;Testing;TREM2 gene;Variant;virtual screening

PROJECT_TITLE: TREM2-endogenous ligand interactions in Alzheimer disease

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Cannabinoid Research;Digestive Diseases;Endocannabinoid System Research;Nutrition;Obesity

ORG_CITY: PISCATAWAY

ORG_DEPT: NUTRITION

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: We will be studying two proteins that are present in the small intestine and that have roles in the uptake and metabolism of dietary lipid, fatty acid-binding protein 1 (FABP1) and fatty acid-binding protein 2 (FABP2). Both FABPs bind fatty acids and endocannabinoids, and we will be identifying other important binding partners for these proteins, as well exploring as their actions in regulating whole body energy metabolism. These studies will provide new understanding of the relationships between intestinal lipids derived from the diet, and their metabolites, with body weight and body fat.t.

PI_NAMEs: SAMPATH, HARINI ;STORCH, JUDITH  (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: Ablation;Address;Affect;Affinity;Albumins;anandamide;Animals;Binding;Binding Proteins;Biochemical;biophysical techniques;Biophysics;Blood;Body fat;Body Weight;Cells;Data;Diet;Dietary Fats;Endocannabinoids;energy balance;Energy Metabolism;Engineering;Enterobacteria phage P1 Cre recombinase;Enterocytes;Enteroendocrine Cell;Epithelial Cells;Exercise;Fatty acid glycerol esters;Fatty Acid-Binding Protein 1;fatty acid-binding proteins;Fatty Acids;glucagon-like peptide 1;Glucose Intolerance;glucose tolerance;Homeostasis;Hormone secretion;improved;in silico;In Vitro;Incubated;Individual;Intake;intestinal epithelium;intestinal fatty acid binding protein;Intestines;kinetic model;Knock-out;Knockout Mice;Lead;Ligand Binding;Ligands;lipid metabolism;lipid transport;lipidomics;Lipids;Liver;long chain fatty acid;Membrane Proteins;Metabolic;Metabolism;Methodology;Methods;Monoglycerides;mouse model;Mouse Protein;Mus;NMR Spectroscopy;novel;Nutrient;Obesity;Organoids;Partner in relationship;Pathway interactions;Performance;Peripheral;Phenotype;Physiological;Plasma;Play;preference;promoter;Protein Analysis;protein expression;protein protein interaction;protein purification;Proteins;Role;sensor;Sensory;Signal Transduction;Signal Transduction Pathway;Small Intestines;Specificity;Structure;Study models;Surface Properties;taste transduction;Tertiary Protein Structure;Testing;Thinness;Tissues;transcriptomics;uptake;villin;Weight Gain;Work

PROJECT_TITLE: Lipid transport in the intestine

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Program Director/Principal Investigator (Last, First, Middle): Ghosh, Arun K. Project narrative: The 2021 UNAIDS reports 38 million people are living with HIV/AIDS (Acquired Immunodeficiency Syndrome) in 2020. The HIV epidemic remains enormous, and progress requires new improved treatment. The present proposal details our design and synthesis of next generation innovative protease inhibitors to address critical problems of existing therapy against this global pandemic. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

PI_NAMEs: GHOSH, ARUN K (contact)

PROGRAM_OFFICER_NAME: NASR, MOHAMED E

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Active Sites;Address;Adherence;ADME Study;Anti-viral Agents;Anti-viral resistance;antiretroviral therapy;Binding;Biological Assay;blood-brain barrier penetration;Caco-2 Cells;Cells;Cellular biology;Chicago;clinical development;Collaborations;combat;Complex;design;Development;Dimerization;Drug Design;drug development;Drug Kinetics;Drug resistance;Effectiveness;Enzymes;Epidemic;Exhibits;experience;FDA approved;Functional disorder;Future;Generations;Genetic;HIV;HIV drug resistance;HIV-1;HIV-1 drug resistance;HIV-1 protease;HIV-associated neurocognitive disorder;Hydrogen Bonding;improved;In Vitro;in vivo;Individual;Infection;inhibitor;inhibitor therapy;innovation;insight;Integrase;Interdisciplinary Study;Kinetics;Laboratories;Lead;Letters;Life Expectancy;Ligands;Managed Care;Medical;medical schools;Metabolic;Metabolism;Microsomes;Modality;Modification;Molecular;molecular modeling;mortality;Multi-Drug Resistance;mutant;Neurocognitive;next generation;novel;pandemic disease;Patient Care;Patients;Penetration;Peptide Hydrolases;Permeability;Persons;Pharmaceutical Chemistry;Pharmacology Study;Pharmacotherapy;preclinical development;Preclinical Drug Development;Prevention;Principal Investigator;professor;programs;Property;Protease Inhibitor;Proteins;Qualifying;Rattus;Regimen;Reporting;Research;Resistance;Resistance development;Resistance profile;Roentgen Rays;side effect;Structure;Structure-Activity Relationship;tool;Toxic effect;transmission process;Treatment Failure;Treatment Protocols;Uncertainty;United States National Institutes of Health;Universities;Variant;Vertebral column;Viral;Viral Physiology;Virus;X-Ray Crystallography

PROJECT_TITLE: Design & Synthesis of Nonpeptide Protease Inhibitors

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Estrogen;Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse;Women's Health Research

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: PROJECT NARRATIVE Substance use disorder (SUD) is a major epidemic, and its impact may be particularly severe for women. One of the most striking examples is “the telescoping effect” wherein women meet criteria for SUD and/or seek treatment after fewer years of drug use as compared to men. Using a novel rat model of the telescoping effect, our goals with this competitive R01 renewal application are to characterize molecular shifts that underlie the telescoping effect with cocaine, and to determine whether, similar to humans, the telescoping effect also occurs with opioids.

PI_NAMEs: LYNCH, WENDY JEAN (contact)

PROJECT_TERMS: Abstinence;addiction;Address;AMPA Receptors;antagonist;base;Biological;ChIP-seq;Cocaine;Cocaine Dependence;cocaine self-administration;cocaine use;Cocaine use disorder;Data;Development;Dopamine D1 Receptor;Drug usage;Epidemic;Epigenetic Process;ESR1 gene;Estradiol;Estrogen Receptor 2;Estrogen Receptors;Event;Female;Fentanyl;fentanyl self-administration;Funding;Gene Expression;Genes;Genetic Transcription;Genomics;Glutamates;Goals;Human;Left;male;Measures;men;Modeling;Molecular;Motivation;novel;Nucleus Accumbens;Opiate Addiction;Opioid;Ovariectomy;Pharmaceutical Preparations;Phenotype;Positioning Attribute;Prefrontal Cortex;prevent;Procedures;psychostimulant;Punishment;Rattus;Receptor Signaling;Relapse;Reporting;Resistance;Role;Saline;Self Administration;sex;Sex Differences;Site;Source;Substance Use Disorder;synthetic opioid;Testing;Time;Tissues;transcriptome sequencing;United States;Woman

PROJECT_TITLE: Dopaminergic and Glutamatergic Mechanisms of Cocaine Addiction: Sex Differences


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE We will examine the associations of extreme heat and wildfire smoke exposures in relation to life expectancy and DNA methylation. In particular, we will evaluate whether air pollution mediates the association between extreme heat and mortality as well as characterize differences in associations across vulnerable populations. The proposed study will be conducted among 112,000 participants from the California component of the Multiethnic Cohort Study.

PI_NAMEs: CHENG, IONA C (contact);WU, ANNA H.;WU, JUN

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: Acute;Address;Adult;Affect;African American population;Age;Aging;aging population;Air;Air Conditioning;Air Pollution;American;Area;Biological;Biological Process;Biometry;Blood;built environment;California;Cessation of life;Climate;climate change;climate impact;climate science;climate zone;cohort;Cohort Studies;Collection;combat;Communities;comorbidity;Coupled;criteria air pollutant;Cross-Sectional Studies;Data;demographics;Diet;DNA Methylation;Education;Elderly;Enrollment;Environment;Environmental Health;Epidemiology;Epigenetic age;epigenetic regulation;epigenome-wide association studies;Ethnic Origin;Ethnic Population;ethnic segregation;European;Evaluation;Event;evidence base;extreme heat;extreme temperature;Fire - disasters;Geography;Green space;Health;Health behavior;health disparity;Heart Diseases;Heat Waves;Heterogeneity;high risk population;Individual;Intervention;Investigation;Japanese American;Joints;Knowledge;Latino;Life Expectancy;low socioeconomic status;Malignant Neoplasms;Measures;Mediating;Mediation;Mediator;men;Mental Health;Methodology;Methods;Modification;Molecular Epidemiology;Morbidity - disease rate;mortality;mortality risk;multi-ethnic;multidisciplinary;Natural Disasters;Neighborhoods;Obesity;Participant;Particulate Matter;Pathway interactions;Physical activity;physical conditioning;Policy Maker;population based;Population Heterogeneity;Population Study;Prospective Studies;public health priorities;Race;racial diversity;Recording of previous events;Research Design;Resources;Respiratory Disease;response;Role;Sampling;Scientist;sex;Smoke;Smoking;social;Social Environment;Social isolation;Socioeconomic Status;socioeconomics;spelling;Surface;Temperature;Testing;Update;Vulnerable Populations;Wildfire;Woman

PROJECT_TITLE: Impact of Climate Change on Life Expectancy in a Multiethnic Population

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alcoholism, Alcohol Use and Health;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative Inflammation in the brain is involved in the pathology of Alzheimer's disease (AD) and alcohol use disorder (AUD). The goal of this project is to determine if heavy/binge alcohol use earlier in life can promote progression of Alzheimer's pathology. This project uses new and innovative therapeutic strategies to test this hypothesis and reverse alcohol-enhancement of AD pathology.

PI_NAMEs: COLEMAN, LEON GARLAND (contact);CREWS, FULTON T

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: 3xTg-AD mouse;abeta deposition;Age;age related;Alcohol consumption;alcohol effect;alcohol use disorder;Alcohols;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid beta-Protein;Apolipoprotein E;Apoptotic;Autopsy;Brain;Brain Diseases;Brain region;CASP3 gene;Cell Death;Chronic;Complement 1q;cytokine;Dementia;Disease;early alcohol use;Ethanol;fluoro jade;gene induction;Genes;Genetic;genome wide association study;Genotype;glial activation;Goals;Hippocampus;HMGB1 gene;Human;Impaired cognition;Impairment;In Situ Nick-End Labeling;in vivo;Individual;Induced Neurons;Induction of Apoptosis;Inflammation;Inflammatory;innovation;Life;Ligands;Link;locomotor deficit;Measurement;Mediating;Mediator;Memory impairment;Microglia;MicroRNAs;Modeling;molecular pathology;molecular phenotype;Molecular Profiling;mouse model;Mus;Nerve Degeneration;Neuroimmune;neuron loss;Neurons;neurotoxic;Nuclear RNA;Pathologic;Pathology;Phagocytes;Phagocytosis;Phenotype;Phosphorylation;Population;Prefrontal Cortex;Proteins;receptor;Receptor Activation;Rest;Reverse Transcriptase Polymerase Chain Reaction;Senile Plaques;Signal Transduction;single nucleus RNA-sequencing;Slice;Stains;Synapses;synaptic pruning;tau aggregation;tau Proteins;tau-1;Testing;Therapeutic;TLR4 gene;TLR7 gene;TNFRSF10A gene;TNFRSF10B gene;Toll-like receptors;transcriptome sequencing;Tumor Necrosis Factor Receptor;Up-Regulation;Western Blotting

PROJECT_TITLE: Microglia Activation and TLR-induced Neurodegeneration by Alcohol Promotes Progression of Alzheimer Pathology


ADMINISTERING_IC: ES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Endocrine Disruptors;Estrogen;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Liver Disease;Nutrition;Obesity;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

PHR: Project Narrative Mechanistic studies pertaining to sex-based differences in the metabolic syndrome are currently insufficient to explain and prevent the higher prevalence of certain metabolic conditions in women versus men and higher prevalence of other symptoms such as hyperlipidemia in men versus women. In addition, epidemiologic studies have reported that exposure to environmental chemicals such as persistent organic pollutants, including organochlorine pesticides, yield different health outcomes in men and women, and therefore, the current project aims to evaluate the underlying cellular mechanisms impacted by sexual dimorphism that potentially drive such differences. The concepts and information that will be gained from this grant will better address sex disparities in environmental health as well as provide health authorities with further knowledge to identify metabolic syndrome-related factors in susceptible populations and design sex-specific therapeutic strategies to better control future health care costs.

PI_NAMEs: WAHLANG, BANRIDA  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: abdominal fat;Address;Affect;Agricultural Workers;Androgen Receptor;arm;authority;Automobile Driving;Award;Binding;bioaccumulation;Biological;Biological Markers;Body Composition;Cardiovascular system;Chemicals;Chlordan;design;Development;Diabetes Mellitus;diet-induced obesity;Disease;Dose;Dyslipidemias;Educational Status;effective intervention;Endocrine;Endocrine disruption;Endocrine Disruptors;Energy Intake;Environment;environmental chemical;Environmental Epidemiology;Environmental Exposure;Environmental Health;epidemiology study;Estrogen Receptors;Ethnic Origin;Exhibits;Exposure to;Female;Food Contamination;Future;Gender;gene interaction;Glucose Intolerance;glucose tolerance;Goals;Gonadal Steroid Hormones;Grant;Habits;Health;Health Care Costs;Hepatic;Hepatotoxicity;High Fat Diet;High Prevalence;Home;Human;Hyperglycemia;Hyperlipidemia;Hypertension;in vitro Model;in vivo Model;Incidence;Ingestion;Injury;Investigation;Isoptera;Knowledge;Lipids;Liver;male;Measures;men;Metabolic;Metabolic Diseases;Metabolic syndrome;Metabolism;Molecular;Morbidity - disease rate;mouse model;Mus;non-alcoholic fatty liver disease;nutrition;Obesity;Organ;organochlorine pesticide;organochlorine pesticide exposure;Outcome;Pathology;persistent organic pollutants;Policy Maker;Polychlorinated Biphenyls;Population;Postmenopause;Predisposition;Prevalence;prevent;Process;Proteome;Proteomics;Public Health;Race;receptor;Receptor Activation;Receptor Signaling;Reporting;Research;Resistance;Risk;Risk Factors;sedentary lifestyle;Serum;sex;Sex Differences;sex disparity;sexual dimorphism;Signal Pathway;Socioeconomic Status;Symptoms;Techniques;Testing;Therapeutic;Toxic effect;toxicant;Training;Vulnerable Populations;Water;Woman;women versus men;Work;Xenobiotics

PROJECT_TITLE: Evaluating mechanisms of sex differences in environmentally-induced metabolic diseases


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Complementary and Integrative Health;Genetics;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE Role of somatosensory Dorsal Root ganglia (DRG) neurons innervating internal organs are underexplored. Specifically, the anatomy and function of these DRG neurons innervating fat pads have remained unknown. In this proposal, with preliminary data in hand, we will utilize various innovative molecular, imaging, and genetic tools to explore the role of fat-innervating DRG neurons.

PI_NAMEs: PATAPOUTIAN, ARDEM  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEN G

PROJECT_TERMS: 3-Dimensional;Ablation;Address;adeno-associated viral vector;Adipocytes;Adipose tissue;Adrenergic Fibers;Affect;Afferent Neurons;Anatomy;Animal Experiments;Autonomic nervous system;Blood Pressure;Brain;Budgets;Cells;Central Nervous System;Chemicals;Cholera Toxin Protomer B;Conscious;cost comparison;Data;Disparate;Energy Metabolism;experimental study;Extravasation;Fatty acid glycerol esters;Female;Fiber;Future;Gene Expression;Genes;Genetic;genetic signature;Genetic Techniques;Goals;Hand;Homeostasis;Hormonal;Human;Image;in vivo;in vivo calcium imaging;innovation;insight;intercellular communication;Interoception;Intervention;invention;Investigation;Ion Channel;Knock-out;Label;Link;Lipid Mobilization;Lipids;Literature;loss of function;Lung;male;Maps;mechanical signal;Mediating;Metabolic;Methods;Modeling;Molecular;Mus;Muscle;Nerve;nerve supply;Neurons;Nodose Ganglion;novel;novel strategies;Nutritional;Obesity;Operative Surgical Procedures;optogenetics;Organ;Output;Pain;Pattern;Physiological;Physiology;programs;Proteins;response;Role;Sensory;Signal Transduction;single-cell RNA sequencing;Skin;somatosensory;Specificity;Spinal;Spinal Ganglia;Stimulus;Stretching;Structure;Sympathetic Nervous System;Technology;Temperature;Testing;Thermogenesis;Tissues;tool;Touch sensation;Tracer;Unconscious State;vector;Viral;Viral Vector;Virus;Visualization

PROJECT_TITLE: The Role of Sensory Neurons Innervating Internal Organs

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative Glioblastoma (GBM), the most lethal and cureless primary brain tumor in adults, carries a notorious yet poorly understood capacity to suppress the host immune system and prevent immune cells from destroying and removing cancer cells. In patient and mouse models of GBM, we find that the primary cilium found on the tumor cell, an antenna/transmitter-like organelle, appears to attract specific immunosuppressive cell types that may keep anti-tumor T cells at a distance. This project will examine this association in detail and determine how the tumor-immune cell landscape develops in mouse and patient tumors depending on their ciliated profiles.

PI_NAMEs: SARKISIAN, MATTHEW ROBERT (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Adult;Affect;Animal Model;anti-tumor immune response;Biopsy;Bone Marrow;Brain Neoplasms;cancer cell;cancer infiltrating T cells;Cell Communication;Cell Physiology;cell type;Cells;Centrioles;chemotherapy;Cilia;cilium biogenesis;Complex;Coupled;Cues;cytotoxic;Data;digital;Distal;effector T cell;Electron Microscopy;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Genes;Glioblastoma;Glioma;Growth;Histologic;Human;human disease;Immune;Immune system;Immune Targeting;Immunity;Immunophenotyping;Immunotherapeutic agent;Immunotherapy;In Situ;In Vitro;in vivo;Infiltration;Interferon Type II;Intracranial Neoplasms;irradiation;Ligands;Macrophage;Malignant neoplasm of brain;Mediating;Microglia;Microtubules;Mitosis;Molecular;monocyte;Mothers;mouse model;Mus;Myeloid-derived suppressor cells;Nature;neoplastic cell;novel;novel strategies;Operative Surgical Procedures;Organelles;Outcome;Patients;Phenotype;Poly A;Positioning Attribute;prevent;Primary Brain Neoplasms;Process;Production;Proteins;Radiation;recruit;Recurrence;Regulation;Reporter;Reporting;Resistance;response;Sensory;SHH gene;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Specimen;standard of care;T-Cell Activation;T-Lymphocyte;temozolomide;Time;Transcript;transcription factor;transmission process;tumor;tumor diagnosis;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Tissue;tumor-immune system interactions;Tumor-infiltrating immune cells;tumorigenesis

PROJECT_TITLE: Regulation of the Tumor Immune Cell Landscape by Ciliated Glioblastoma Cells

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Many human behavioral disorders and mental diseases arise from naturally occurring genetic and molecular changes altering neuronal functions. By leveraging natural species diversity in a genetically and neuronally tractable system, our research program will establish the key missing links between the and underpinnings causal mechanisms natural behavioral variations, providing complementary insights into the genetic and molecular of human neurological diseases and human-specific behavioral traits.

PI_NAMEs: DING, YUN  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Behavior;Behavior Disorders;Behavioral;Biological;Biological Models;Biology;causal variant;Cells;Chromosome Mapping;Complex;Courtship;Disease;Dissection;Drosophila genus;Etiology;Evolution;Gene Expression;Gene Silencing;Genes;Genetic;genetic testing;Genetic Variation;Genomic Segment;Goals;Human;Human Genetics;innovation;insight;Knowledge;Label;Link;Mediating;Molecular;Morphology;Mutation;Nature;Nervous System;Nervous System Disorder;neural;Neurons;Neurophysiology - biologic function;Phenotype;Physiological;programs;Psyche structure;Research;Resolution;Site;System;trait;transcriptome;Variant

PROJECT_TITLE: From association to causation: pinpointing the genetic and molecular determinants underlying natural behavioral variations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-U(55)R]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Eating Disorders;Mental Health;Mental Illness;Neurosciences;Nutrition;Obesity

ORG_CITY: Nashville

ORG_DEPT: PHYSIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Despite an increased prevalence of both feeding and anxiety disorders, the key neural inputs linking these two states, and the potential heterogeneity between males and females, remain poorly understood. This proposal will be the first step in defining the role of the melanocortin-3 receptor (MC3R) in the integration of feeding and anxiety which could ultimately lead to new therapeutic treatments for maladaptive feeding behaviors associated with obesity and eating disorders.

PI_NAMEs: BEDENBAUGH, MICHELLE  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Anatomy;Anorexia;anorexic;Anxiety;Anxiety Disorders;anxiety-like behavior;Area;Automobile Driving;Axon;Behavior;Behavioral;Behavioral Paradigm;Binge Eating;Brain;Brain Stem;Cell Nucleus;Cells;Clinical;Communication;Complex;Confocal Microscopy;Cues;Development;Disease;driving behavior;Eating;Eating Disorders;Emotional;energy balance;Experimental Genetics;experimental study;Failure;Fasting;feeding;Feeding behaviors;Female;food avoidance;food consumption;Food Energy;Future;Heterogeneity;Homeostasis;Hormones;Hypothalamic structure;Image Analysis;Immunohistochemistry;in vivo calcium imaging;Individual;Label;Link;male;Maps;Mediating;Melanocortin 3 Receptor;Metabolic;Methods;microendoscopy;molecular phenotype;motivated behavior;Mus;neural;neural circuit;Neurologic;Neurons;Neurosecretory Systems;novel;novel therapeutic intervention;novel therapeutics;Nuclear;Obesity;Output;Pathologic;Pathological anxiety;Phenotype;Physiological Processes;Population;Positioning Attribute;Predisposition;Prevalence;Process;Psychopathology;receptor expression;Regulation;response;restraint stress;Role;sex;Sex Differences;sexual dimorphism;Signal Transduction;Site;Social isolation;Stress;stressor;Structure of terminal stria nuclei of preoptic region;System;Testing;Three-Dimensional Image;Time;Tissues;Viral;Work

PROJECT_TITLE: Melanocortin-3 receptor in feeding and anxiety neural circuits

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome;Pediatric;Pediatric Cardiomyopathy;Prevention;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Hypertrophic cardiomyopathy is the most common genetic cardiac disease and causes a variety of major cardiovascular events such as arrhythmias, heart failure, stroke, and sudden cardiac death; however, effective pharmacotherapies to prevent disease manifestation or cardiovascular events are not available. In an ongoing, large multi-center cohort of patients with hypertrophic cardiomyopathy, the investigators will define the role of signaling pathway dysregulation in the disease pathobiology and the development of cardiovascular events by performing parallel transcriptomic profiling in both myocardium and plasma. This research has the potential to identify molecular targets for the prevention of disease manifestation and progression, and to offer novel approaches to specify high-risk subpopulations that benefit most from preventive interventions.

PI_NAMEs: SHIMADA, YUICHI  (contact)

PROGRAM_OFFICER_NAME: ANAYA, GABRIEL

PROJECT_TERMS: Affect;Age;Animals;Arrhythmia;biobank;Biological;Biological Markers;Cardiac;Cardiomyopathies;Cardiovascular system;circulating microRNA;Clinical;Clinical Data;clinical heterogeneity;Clinical Management;Clinical Markers;clinical phenotype;cohort;Data;Development;Devices;Disease;Disease Progression;disorder prevention;drug development;Enrollment;Event;evidence base;experience;Family;follow-up;Gene Mutation;Genetic;Goals;Heart;Heart Diseases;Heart failure;Heart Hypertrophy;Heterogeneity;high risk;Human;hypertensive;Hypertrophic Cardiomyopathy;Image;implantation;improved;In Situ Hybridization;inhibitor;insight;Intervention;Interview;Knowledge;Left;Left Ventricular Hypertrophy;MAP Kinase Gene;Matched Case-Control Study;Mediating;Medical Records;Messenger RNA;microRNA biomarkers;MicroRNAs;Modeling;Molecular;molecular drug target;Molecular Target;Myocardial dysfunction;Myocardium;National Heart, Lung, and Blood Institute;novel;novel strategies;Pathogenesis;Pathway interactions;Patient Selection;Patients;Persons;Pharmacotherapy;Phenotype;Plasma;prevent;preventive intervention;Preventive therapy;prospective;Prospective cohort;Prospective Studies;Proteomics;Quantitative Reverse Transcriptase PCR;Recording of previous events;Reporting;Research;Research Personnel;response;retention rate;Risk;risk stratification;RNA;Role;Sampling;sex;Signal Pathway;Specific qualifier value;Strategic Planning;Stroke;sudden cardiac death;System;targeted treatment;Testing;Time;Transcript;transcriptome sequencing;transcriptomic profiling;transcriptomics;unsupervised clustering;Untranslated RNA;Up-Regulation;Validation;Ventricular;Work

PROJECT_TITLE: Transcriptomics, pathobiology, and cardiac event in hypertrophic cardiomyopathy

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Genetics;Rare Diseases

ORG_CITY: SIOUX FALLS

ORG_NAME: SANFORD RESEARCH/USD

ORG_STATE: SD

PHR: PROJECT NARRATIVE Chemical reactions in cells require enzymes to proceed efficiently. Many enzymes need dedicated “helper molecules” called cofactors. When cofactors are deficient, our enzymes do not function correctly leading to metabolic disease. This project aims to understand how cells maintain appropriate levels of the essential molybdenum cofactor and cope with metabolic imbalance when molybdenum cofactor is deficient. Molybdenum cofactor deficiency is a rare genetic disorder that causes neonatal lethality in humans. Our fundamental insights into molybdenum cofactor biology will inform new therapeutic strategies for this and related diseases.

PI_NAMEs: WARNHOFF, KURT  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Animals;Area;Biochemistry and Cellular Biology;Biological Availability;Biology;Caenorhabditis elegans;Cells;chemical reaction;cofactor;Combined molybdoflavoprotein enzyme deficiency;coping;dalton;Dedications;dietary;Disease;Enzymes;functional genomics;Genes;Genetic;genetic analysis;genetic approach;Goals;Health;Homeostasis;Human;Inborn Errors of Metabolism;insight;interdisciplinary approach;Life;loss of function mutation;Mediating;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolism;model organism;molybdenum cofactor;Neonatal;novel therapeutic intervention;Pathway interactions;programs;Prosthesis;Proteins;purine metabolism;Purines;rare genetic disorder;Regulatory Pathway;Research;sulfite oxidase;Sulfur Amino Acids;Sulfur Metabolism Pathway;uptake;Work;XDH gene

PROJECT_TITLE: Genetic analyses of molybdenum cofactor biology


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Prevention;Primary Health Care;Sexually Transmitted Infections;Women's Health Research

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: The overarching goal of the “Partnership for Advancing Cervical Cancer Prevention in Women Living with HIV” is to improve the cascade of cervical cancer prevention for women living with HIV (WLWH) including increasing uptake of cervical cancer screening services, improving management of screen positive women, and optimizing precancer treatment outcomes, particularly in resource-constrained settings. Partnership members have established collaborations with a history of conducting successful clinical trials and impacting clinical care. As a CASCADE Research Base, we will provide impactful scientific and statistical direction for pragmatic clinical trials to be conducted at the CASCADE Clinical Sites.

PI_NAMEs: CHIBWESHA, CARLA J;GIULIANO, ANNA R.;WILKIN, TIMOTHY J. (contact)

PROGRAM_OFFICER_NAME: FRECH, MARIA SILVINA

PROJECT_TERMS: Adherence;Adoption;Affect;Aftercare;AIDS clinical trial group;AIDS Malignancy Consortium;antiretroviral therapy;Area;automated visual evaluation;base;Cancer Prevention Trial;career;career development;Cervical;cervical cancer prevention;Cervical Cancer Screening;Characteristics;Clinic;Clinical;clinical care;Clinical Research;clinical research site;Clinical Trials;Cold Therapy;Collaborations;Colposcopy;Communication;community engagement;Consolidated Framework for Implementation Research;cost;Data;Decision Making;design;Detection;Development;Division of Cancer Prevention;Effectiveness;effectiveness evaluation;effectiveness outcome;experience;Fluorouracil;Fostering;Frequencies;Future;Goals;HIV;HPV screening;HPV-High Risk;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;implementation evaluation;implementation outcomes;implementation science;improved;improved outcome;Individual;Infrastructure;Institution;International;Intervention;Investigation;Leadership;loop electrosurgical excision procedure;low and middle-income countries;Maintenance;Malignant neoplasm of cervix uteri;member;Mentors;Patients;Performance;Persons;Physicians;point of care;Positioning Attribute;Pragmatic clinical trial;pragmatic trial;premalignant;prevention service;Prevention trial;Primary Care;Process;protocol development;randomized, clinical trials;Recording of previous events;repository;Research;Research Personnel;Resource-limited setting;Sampling;scale up;screening;screening services;Sensitivity and Specificity;Site;skills;Specimen;Squamous intraepithelial lesion;standard of care;Testing;Treatment outcome;treatment trial;Triage;uptake;Visual;Woman;women's prevention;Work

PROJECT_TITLE: Partnership for advancing cervical cancer prevention in women living with HIV (CASCADE - Research Hub)


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: The Medical Scientist Training Program (MSTP) at Baylor College of Medicine is designed for highly motivated students who want to by combine their passion for translational research and patient as a physician scientist to meet the Nation's needs for biomedical workforce. The BCM- MSTP is committed to training a diverse group of students from all backgrounds through a rigorous integrative dual MD/PhD degree program that empowers them to be successful in their careers as physician-scientists.

PI_NAMEs: FRANKFORT, BENJAMIN J;KING, KATHERINE YUDEH (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: Medical Scientist Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]