ORG_CITY: SEATTLE

ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

ORG_STATE: WA

PHR: PROJECT NARRATIVE Islet amyloid formation results in mitochondrial dysfunction leading to β-cell death and secretory dysfunction in type 2 diabetes. Concentrations of the cholesterol transport protein Steroidogenic Acute Regulatory Protein (StAR) in the islet increase with amyloid formation, and increase cholesterol transport to mitochondria. The lack of cleavage enzymes (CYPs) in the β-cell means that the subsequent metabolism of cholesterol will not occur, thereby leading to cholesterol accumulation, mitochondrial dysfunction and subsequently β-cell death and secretory dysfunction. By advancing our understanding of the role of StAR in β-cell cytotoxicity, the project endeavors to develop new approaches to preserve β-cells and thereby prevent or treat type 2 diabetes. Given the burden of type 2 diabetes amongst Veterans, developing new approaches to reduce the morbidity and mortality of the disease is critical.

PI_NAMEs: KAHN, STEVEN EMANUEL (contact)

PROJECT_TERMS: Acute;Address;Amyloid;Amyloid deposition;amyloid formation;Apoptosis;ATP binding cassette transporter 1;Beta Cell;Bile Acids;Binding;Brain;Carrier Proteins;Cell Death;Cell Survival;Cells;Characteristics;Cholesterol;Cholesterol Homeostasis;Chronic;Cleavage Under Targets and Release Using Nuclease;Cyclic AMP-Responsive DNA-Binding Protein;CYP11A1 gene;cytotoxicity;Data;Deposition;Disease;DNA sequencing;Dominant-Negative Mutation;Enzymes;Functional disorder;Genetic Induction;genetic regulatory protein;Glucocorticoids;Glucose;Gonadal Steroid Hormones;Heart;High Fat Diet;Human;Impairment;In Vitro;in vivo;Inner mitochondrial membrane;islet;islet amyloid polypeptide;Islet Cell;knock-down;Knockout Mice;Liver;Mediating;Mediator;Metabolism;Mineralocorticoids;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Morbidity - disease rate;mortality;Mus;neurosteroids;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;overexpression;Oxidative Stress;Oxygen Consumption;Pathogenesis;Pathologic;Peptides;Phosphorylation;preservation;prevent;Production;promoter;Protein Deficiency;protein expression;Protein Overexpression;protein transport;response;Role;Secretory Cell;small hairpin RNA;steroidogenic acute regulatory protein;Steroids;Techniques;Tissues;Toxic effect;transcription factor;Transfection;Transgenic Mice;Up-Regulation;Veterans;Virus

PROJECT_TITLE: Pathogenesis and Impact of Islet Amyloid


ADMINISTERING_IC: VA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: PORTLAND

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Tuberculosis remains an important cause of infectious disease morbidity and mortality worldwide, and remains a problem of particular concern to those in the armed forces. The organism that causes tuberculosis, Mycobacterium tuberculosis, is an intracellular pathogen such that improved definition of those mechanisms by which the immune system recognizes intracellular infection provides direct application to improved vaccines and diagnostics. This application is focused on understanding how a unique population of innate human CD8+ T cells identify those cells containing Mtb.

PI_NAMEs: LEWINSOHN, DAVID M. (contact)

PROJECT_TERMS: Accounting;Anabolism;Antigens;Categories;CD8-Positive T-Lymphocytes;Cell surface;Cells;Cessation of life;Clinical;clinically relevant;Collaborations;Communicable Diseases;Data;Development;Diagnostic;direct application;Endosomes;Environment;Exposure to;Extended Family;Family;Funding;Grant;Household;Human;Immune response;Immune system;improved;Infection;Intestines;Laboratories;Learning;Ligands;Location;Lung;Macrophage;Memory;microbial;Molecular;Molecular Chaperones;Morbidity - disease rate;mortality;Mucous Membrane;mycobacterial;Mycobacterium tuberculosis;Organism;Outcome;pathogen;Peptides;Play;Population;Predisposition;Prevalence;Process;Program Reviews;programs;Proteins;Research Proposals;Resistance to infection;response;Riboflavin;RNA Splicing;Role;Sampling;small molecule;T-Lymphocyte;Thymus Gland;Tissues;trafficking;Tuberculosis;tuberculosis immunity;Umbilical Cord Blood;Universities;uptake;Vaccines;Variant;Vesicle;Vitamin B Complex;Washington;Work

PROJECT_TITLE: Recognition of Mtb-Infected Cells by Non-Classically Restricted CD8+ T Cells


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PI_NAMEs: WAN, MEI  (contact)

PROJECT_TERMS: Acceleration;Affect;age related;age related chronic disease;Aging;angiogenesis;Angiogenic Factor;Ankle;Apoptosis;arthropathies;articular cartilage;Attenuated;Blood Vessels;Bone Marrow;Bone Marrow Cells;Bone Resorption;Bone Tissue;Cartilage;Cell Aging;Cell Cycle Arrest;Cell Proliferation;cell type;Cells;Chronic;Clinical Research;Deceleration;defined contribution;Degenerative polyarthritis;Deterioration;Development;Diagnostic;Disease;driving force;Elderly;epidemiology study;Frail Elderly;frailty;Functional disorder;functional loss;Genes;Genetic;genetic approach;Goals;hallmarks of aging;Hand Osteoarthritis;High Fat Diet;Hip Osteoarthritis;Human;Invaded;joint destruction;joint injury;Joints;Knee joint;Knee Osteoarthritis;Measures;Mechanics;Metabolic;metabolic phenotype;Metabolic syndrome;Mononuclear;mouse model;Mus;Musculoskeletal Diseases;novel;Nuclear;Obesity;old mice;osteoarthritis pain;Osteoclasts;Osteogenesis;overexpression;participant enrollment;Pathogenesis;Pathogenicity;pharmacologic;Phenotype;Physiologic Ossification;platelet-derived growth factor BB;Population;Prevalence;radiological imaging;Reporter;Risk Factors;Role;senescence;senescence associated secretory phenotype;senescent cell;Skeleton;subchondral bone;Synovial Membrane;Testing;Tissues;Transgenic Organisms;Traumatic Arthropathy;treatment strategy;Tube;Vascular Endothelial Cell;Work

PROJECT_TITLE: Senescence of Pre-Osteoclasts in Non-Traumatic OA


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PI_NAMEs: EARP, H. SHELTON (contact)

PROJECT_TERMS: Address;anti-cancer research;Area;Attention;Authorization documentation;Award;Basic Science;Budgets;Cancer Center Support Grant;cancer health disparity;care delivery;Catchment Area;Categories;Centers of Research Excellence;Clinical;Clinical Research;Clinical Sciences;Collaborations;Communities;community engagement;Community Outreach;community partners;community-centered;Comprehensive Cancer Center;cost effective;Development;Discipline;Disease;Education;Educational Status;Expenditure;Extramural Activities;Faculty;Faculty Recruitment;fundamental research;Funding;Future;Grant;Growth;Guidelines;high risk;innovation;Institution;Interdisciplinary Study;Investments;Link;Malignant Neoplasms;malignant stomach neoplasm;Measures;Methodology;Mission;neoplastic;new technology;North Carolina;novel strategies;Pilot Projects;Population;Population Sciences;Population Study;Process;programs;Publications;Quality of Care;recruit;Research;Research Priority;Resource Sharing;Resources;Schools;Scientist;Strategic Planning;success;Technical Expertise;Training and Education;Translating;Translational Research;Translations;UNC Lineberger Comprehensive Cancer Center;Universities;Work;Writing

PROJECT_TITLE: Developmental Funds

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative  The preterm birth rate in Harris County, Houston, TX is an alarming 13.6% (national average in US is 9.6%), and in areas surrounding the superfund sites, the preterm birth (PTB) rate is even higher (> 20%). The overarching goal of the Baylor-Rice Superfund Research Program (SRP) is to that maternal exposure to PAHs, which are present in superfund sites, increases the risk of PTBs and incrementally augments major morbidities such as chronic lung disease [bronchopulmonary dysplasia (BPD] in premature infants and neurocognitive deficits later in life. These studies proposed here should lead to reduction of health burden associated with PAHs in Superfund sites, and should also help in risk assessment strategies by partnering with EPA, ARSDR, Texas department of Health, etc.

PI_NAMEs: MOORTHY, BHAGAVATULA  (contact)

PROGRAM_OFFICER_NAME: CARLIN, DANIELLE J

PROJECT_TERMS: absorption;Address;Adult;aerosolized;Air;Area;Aromatic Polycyclic Hydrocarbons;Biological;Biomedical Research;Birth Rate;Bronchopulmonary Dysplasia;Chemicals;Child;Childhood;Chronic lung disease;Cities;Clinical;Collaborations;commercialization;Communication;community collaboration;community engagement;County;Data;Data Analyses;data management;Detection;detection method;Devices;Dust;early life exposure;Engineering;Enrollment;Environment;Environmental Health;Environmental Science;Evaluation;experience;Exposure to;Fostering;Goals;Hazardous Chemicals;Hazardous Substances;Health;Human;innovation;Intervention;Life;Maternal Exposure;Measures;Methods;Molecular;Morbidity - disease rate;nanoengineering;nanomaterials;National Institute of Environmental Health Sciences;Neonatal;Neurocognitive Deficit;next generation;novel;novel strategies;Optics;Oregon;Outcome;Patients;Persons;Physicians;Placenta;Postdoctoral Fellow;Premature Birth;Premature Infant;prevent;Prevention;programs;Public Health;public health emergency;remediation;Research;Research Personnel;Research Project Grants;Research Support;Resources;Rice;Risk;Risk Assessment;Risk Factors;Sampling;Scientist;Sister;Site;Soil;Spectrum Analysis;student training;Superfund;superfund site;Surface;Technology;Technology Transfer;Testing;Texas;Toxic effect;Training;Translational Research;wasting;Water;Woman;Wrist;wristband

PROJECT_TITLE: POLYCYCLIC AROMATIC HYDROCARBONS: ULTRASENSITIVE DETECTION, EARLY LIFE EXPOSURES-CLINICAL OUTCOMES (PRETERM BIRTHS, CHRONIC LUNG DISEASE, AND NEUROCOGNITIVE DEFICITS), PREVENTION AND REMEDIATION


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: EAST LANSING

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative Cyclic di-nucleotides are central second messenger signaling molecules that allow living systems to connect changes in their external environment to regulation of adaptive behaviors. This proposal will address fundamental questions about cyclic di-nucleotide signaling in both prokaryotic and eukaryotic organisms.

PI_NAMEs: WATERS, CHRISTOPHER M (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Adaptive Behaviors;anti-cancer;Bacteria;bacterial fitness;Bacterial Proteins;Bacteriophages;biological adaptation to stress;Cells;cellular development;Cellular Morphology;Complex;Cyclic GMP;Dinucleoside Phosphates;DNA Repair;Environment;Eukaryota;Eukaryotic Cell;Gene Expression;Gene Expression Regulation;Genetic Transcription;Heat-Shock Response;Human;Immune response;in vivo;Innate Immune System;Laboratories;Life;Microbial Biofilms;Molecular;Motility;Names;novel;Organism;Output;pathogenic bacteria;Pathway interactions;Periodicity;Phenotype;Phospholipases A;Phylogenetic Analysis;Physiology;Play;posttranscriptional;Production;Pyrimidine;receptor;Regulation;Research;response;Saccharomyces cerevisiae;Second Messenger Systems;sensory system;Signal Induction;Signal Pathway;Signal Transduction;Signaling Molecule;System;Trees;Vibrio cholerae;Viral Cancer;Virulence;Yeasts

PROJECT_TITLE: Exploring cyclic di-nucleotide signaling across the tree of life

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Genetics;Infectious Diseases;Microbiome;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE: The primary objective of this R01 is to investigate the pathogenesis of incident bacterial vaginosis (iBV) using a combination of cultivation independent and cultivation dependent studies. A notable feature of BV is the appearance of a multi-species bioﬁlm on vaginal epithelial cells. We hypothesize that Gardnerella vaginalis initiates BV biofilm formation, but that iBV requires incorporation of other key bacteria (Prevotella bivia and Atopobium vaginae) into the biofilm that alter the transcriptome of the polymicrobial consortium. [By further investigating the etiology of BV, this study has great potential to improve diagnosis, treatment, and prevention.]

PI_NAMEs: MUZNY, CHRISTINA A (contact)

PROGRAM_OFFICER_NAME: CHUANG, ELEANORE JENNIFER

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;adverse outcome;Age;Anaerobic Bacteria;Appearance;Atopobium vaginae;Bacteria;Bacterial Vaginosis;Cells;Chemicals;design;Development;Diagnosis;epidemiologic data;Epithelial Cells;Etiology;Exhibits;Fluorescent in Situ Hybridization;Gardnerella;Gardnerella vaginalis;Genes;Hela Cells;HIV;improved;In Vitro;in vitro Assay;in vitro Model;in vivo;interest;Lactobacillus;Laser Scanning Confocal Microscopy;light microscopy;Longitudinal Studies;men;Menstrual cycle;Microbial Biofilms;microbiome analysis;microorganism interaction;molecular marker;normal microbiota;Organism;pathogen;Pathogenesis;Pathway Analysis;Pelvic Inflammatory Disease;Peptide Nucleic Acids;polymicrobial biofilm;Premature Birth;Prevention;Prevotella;Public Health;Recurrence;Research;Risk;rRNA Genes;Sampling;sex;Sexual Transmission;Sexually Transmitted Diseases;Specimen;Time;transcriptome;transcriptome sequencing;Vagina;Vaginal Discharge;vaginal lactobacilli;vaginal microbiota;virulence gene;Virulent;Woman;women who have sex with women

PROJECT_TITLE: Microbial Interactions between Gardnerella, Prevotella, and Atopobium Prior to Incident Bacterial Vaginosis

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related

ORG_CITY: ANN ARBOR

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: This proposal, entitled Community-Centered Interventions for Improved Vaccine Uptake for COVID (CIVIC) involves a community-based intervention designed to increase the uptake of the COVID-19 vaccine in African- American and Latinx communities. Using a community-based participatory research (CBPR) approach, CIVIC will leverage our long term relationships with our expert community partners, the resources and networks of the University of Michigan CTSA (MICHR), our CBPR partnership developed and knowledge gained as a Community Engagement Alliance (CEAL) grant recipient, and the proficiency of our academic partners, to identify and understand factors that contribute to COVID-19 vaccine hesitancy in AA and LX communities in Michigan and develop and test novel multilevel interventions to achieve the primary goal of increased vaccine uptake.

PI_NAMEs: MARSH, ERICA E (contact);RESNICOW, KEN A.

PROGRAM_OFFICER_NAME: JONES, NANCY LYNNE

PROJECT_TERMS: Address;African American;African American population;Cessation of life;Church;Cities;Color;Communities;community based participatory research;community engagement;Community Health Aides;community intervention;community involvement;community partners;community-centered;comparison intervention;Country;County;COVID-19;COVID-19 burden;COVID-19 disparity;COVID-19 misinformation;COVID-19 mortality;COVID-19 vaccine;culturally appropriate intervention;Data;Decision Making;design;Disparity;effectiveness evaluation;Equity;ethnic disparity;Ethnic Population;Evaluation;experience;Faith-based organization;Fright;Goals;Grant;health disparity;health equity;health equity promotion;health inequalities;Hispanic;improved;Individual;interest;Internet;Intervention;Interview;Knowledge;knowledge integration;Latinx;Learning;Letters;Low income;member;Michigan;novel;outcome disparities;Ownership;Population;Positioning Attribute;Process;Public Health;Race;Racial Equity;Randomized;Research;Resources;response;shared decision making;Social Marketing;success;Testing;therapy design;Training;trend;Universities;uptake;vaccine acceptance;vaccine hesitancy;web site

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-G(90)S]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Rural Health;Social Determinants of Health

PROJECT_TERMS: Advisory Committees;anti-cancer research;Area;Arts;Basic Science;Cancer Center;Cancer Center Support Grant;Cancer Survivor;career;Caregivers;Catchment Area;Cell Therapy;Clinical Research;Clinical Sciences;Clinical Trials;cohort;college;Communities;community advisory board;community college;community engagement;Community Outreach;cost efficient;Data;Decision Making;Disease;Education;Ensure;Epigenetic Process;Ethnic Origin;Evaluation;Exhibits;Faculty;Faith-based organization;falls;Funding;Geography;Group Meetings;Healthcare Systems;high school;Hospitals;Immunotherapy;improved;Inflammation;Infrastructure;Institution;Investments;Leadership;Malignant Neoplasms;medical schools;meetings;member;Methods;Minority;minority disparity;Mission;North Carolina;Obesity;Pharmacy facility;population based;Population Sciences;Population Study;Postdoctoral Fellow;Preparation;Prevention Research;Process;programs;Public Health;Race;recruit;Reporting;Research;research and development;Research Priority;Resource Development;Resource Sharing;Resources;Risk Factors;Rural;rural area;Schools;Science;Scientist;Strategic Planning;Structure;Teacher Professional Development;Technology;technology development;Training;Translational Research;undergraduate student;Underrepresented Minority;Universities;urban area;urban disparity;Workforce Development;working group

PROJECT_TITLE: Planning and Evaluation


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: IOWA CITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: NARRATIVE: Iowa Superfund Research Program Overall The Iowa Superfund Research Program (ISRP) will expand our understanding of the sources, avenues of exposure, toxic effects, and remediation of polychlorinated biphenyls (PCBs), a large family of environmental pollutants that cause neurodevelopmental impairment, metabolic syndrome, and cancer in humans. ISRP research will focus on airborne PCBs, in buildings (especially schools) and emitted from contaminated waters (often near Superfund sites), and the potential health impacts of inhaled PCBs, particularly in adolescents. ISRP research will produce important data and innovative tools to support the development of effective detection, risk assessment, management, and remediation strategies for federal, state, and community stakeholders impacted by these contaminants and concerned with protecting human health.

PI_NAMEs: HORNBUCKLE, KERI C (contact)

PROGRAM_OFFICER_NAME: HENRY, HEATHER F

PROJECT_TERMS: Address;Adolescence;Adolescent;Air;Area;Bacteria;Biochemical;Biological;building materials;career;Centers of Research Excellence;Chemicals;Child;cohort;Communication;Communities;community engagement;Complex;Construction Materials;contaminated sediment;contaminated water;cost effective;Data;Data Science;design;Detection;detection method;Development;Diet;dietary;Environment;Environmental Health;Environmental Pollutants;Evaluation;experience;exposed human population;Exposure to;Family;fungus;Goals;Health;Home;Household;Human;improved;Individual;Indoor environment;Industrialization;Inhalation;Inhalation Exposure;innovation;Intervention;Iowa;lipid metabolism;Malignant Neoplasms;Metabolic;Metabolic syndrome;Methods;microbial;Molecular;Mothers;neurodevelopment;Neurodevelopmental Impairment;new technology;novel;novel strategies;Personal Satisfaction;Persons;Poison;Polychlorinated Biphenyls;Population;Predisposition;prevent;Process;Program Research Project Grants;programs;Recommendation;remediation;Research;Research Activity;Research Personnel;Research Priority;Research Project Grants;Risk Assessment;Risk Factors;Route;Schools;Scientist;Site;skills;Soil;Source;Superfund;superfund chemical;superfund site;Testing;tool;Toxic effect;Training;Training Programs;Translating;Translational Research

PROJECT_TITLE: Airborne PCBs: Sources, Exposures, Toxicities, Remediation


NIH_SPENDING_CATS: Endocrine Disruptors;Lung;Neonatal Respiratory Distress;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

PHR: CORE A: ADMINISTRATIVE CORE – PROJECT NARRATIVE The over-arching hypothesis of the BCM-Rice Superfund Research Program (SRP) is that maternal exposure to polycyclic aromatic hydrocarbons (PAHs), which are present in Superfund sites, increases the risk of preterm births (PTB) and incrementally augments major morbidities such as bronchopulmonary dysplasia (BPD) and neurocognitive deficits in premature infants and toddlers/older children, respectively. The AC will work closely with the community engagement core and the stakeholders such as EPA, TCEQ, and ATSDR to address concerns regarding the risks of exposure of PAHs to pregnant women living in the vicinity of superfund sites, and jointly develop strategies to minimize the risk to people living near Superfund sites.

PROJECT_TERMS: 3-Dimensional;Address;Advisory Committees;Area;Aromatic Polycyclic Hydrocarbons;Biological Markers;Birth Rate;Bronchopulmonary Dysplasia;Businesses;Child;Chronic lung disease;Clinical;Collaborations;college;Committee Members;Communication;Communities;community center;community collaboration;community engagement;community partners;Country;County;Creativeness;Data;Data Analyses;data management;data sharing;Detection;Development;Discipline;disease registry;early life exposure;Education;Ensure;Environmental Engineering technology;Environmental Health;Epidemiology;experience;Exposure to;Feedback;Fostering;Goals;Government;Government Agencies;Grant;Health;Health Professional;improved;Information Dissemination;Interdisciplinary Communication;investigator-initiated translational research;Leadership;Legal patent;Life;Maternal Exposure;Medical;Medical center;Medicine;meetings;member;Morbidity - disease rate;National Institute of Environmental Health Sciences;Neurocognitive Deficit;Newsletter;Occupational activity of managing finances;Office of Administrative Management;Organizational Efficiency;organizational structure;Outcome;Patients;Persons;Play;Poison;population based;Pregnant Women;Premature Birth;Premature Infant;Prevention;programs;Public Health;remediation;Research;Research Project Grants;Research Support;Resources;Rice;Risk;Risk Assessment;Risk Factors;risk minimization;Role;Science;science teacher;Sister;Site;Soil;success;Superfund;superfund site;System;Technology Transfer;Texas;Toddler;Training;Training Programs;translational potential;Translational Research;United States Environmental Protection Agency;Universities;Update;Water;web site;webinar;Work

PROJECT_TITLE: Core A: Administrative and Research Translation Core (ARTC)


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Comparative Effectiveness Research;Emergency Care;Neurosciences;Patient Safety

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Medical and traumatic emergency conditions affecting the cardiac, respiratory, nervous, and hematologic systems collectively account for  the overwhelming preponderance of death and disability affecting Americans. The ongoing COVID-19 pandemic has brought into stark relief the importance of emergency care research to rapidly evaluate treatments, and the disproportionate burden that underserved populations suffer. It is imperative that new approaches for timely diagnosis and equitable treatment of these conditions be efficiently developed.

PI_NAMEs: COOPER, RICHELLE J.;LEWIS, ROGER J;SAVER, JEFFREY L;YADAV, KABIR  (contact)

PROGRAM_OFFICER_NAME: SCOTT, GRETCHEN CARLYLE

PROJECT_TERMS: Accident and Emergency department;Acute;Adult;Affect;African American population;Allied Health Personnel;Ambulances;American;Award;California;Cardiac;career;Cessation of life;Child;Childhood;Clinical;Clinical and Translational Science Awards;clinical practice;clinical training;Clinical Trials;Clinical Trials Network;Collaborations;Colorado;Complex;Country;County;COVID-19 pandemic;Data Collection;decision-making capacity;Dedications;Diagnosis;disability;Disease;educational atmosphere;Emergency Care;Emergency Department Physician;Emergency Medicine;Emergency research;Emergency Situation;Enrollment;Ensure;Equity;evidence base;experience;Faculty;Fellowship Program;Goals;Hematology;Hispanic Americans;Hospital Departments;Hospital Personnel;Hospitals;Impairment;improved outcome;Individual;Infrastructure;innovation;Inpatients;Interdisciplinary Study;interest;Intervention;Intervention Trial;Investments;Knowledge;Leadership;Longevity;Los Angeles;Medical;Medical center;Medical Students;Medicine;member;Mentors;Mentorship;Multi-Institutional Clinical Trial;National Clinical Trials Network;National Heart, Lung, and Blood Institute;National Institute of Neurological Disorders and Stroke;Nervous System;Neurologic;Nevada;next generation;novel strategies;Nurses;operation;Operative Surgical Procedures;Oranges;outreach;Paramedical Personnel;Patient-Focused Outcomes;Patients;performance site;Physicians;Population;Pragmatic clinical trial;pragmatic trial;Productivity;profession allied to medicine;recruit;Research;Research Personnel;Resources;respiratory;Self Perception;skills;Southwestern United States;Specialist;success;Supervision;System;Time;Time Study;Training;Trauma;trial design;Underrepresented Populations;Underserved Population;United States;United States National Institutes of Health;Universities;Woman

PROJECT_TITLE: Southwest Strategies to Innovate Emergency Care Clinical Trials Network (SW SIREN)


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biomedical Imaging;Clinical Research;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative: Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract that impacts over 800,000 patients in the US alone, where characteristic periods of remission and relapse necessitate frequent, costly hospitalizations and symptoms such as bloody diarrhea, abdominal pain, general malaise, and fever significantly compromise quality of life. There is a need for new tools aimed at the reliable assessment of disease activity by using objective markers to improve diagnostic accuracy, quantify disease burden, and monitor treatment efficacy, enabling subsequent treatments tailored to the individual patient's disease profile. The primary objective of this project is three-fold: First, to develop and validate a novel, noninvasive, contrast- and radiation-free quantitative MR imaging and image analysis technique, i.e., DiMoCo-SPIM that will generate robust and reproducible imaging markers from DW-MRI that will enable clinicians to more accurately assess bowel inflammation and response to therapy; second, to develop a machine learning technique that reduces the imaging time (x4 acceleration); and third, to make image analysis software developed in this proposal available in multiple clinical domains that presently evaluate various diseases with MRI and would benefit from the improved diagnostic and assessment capabilities of this computationally-driven technique.

PI_NAMEs: KURUGOL, SILA  (contact)

PROGRAM_OFFICER_NAME: KLAPPROTH, JAN-MICHAEL AXEL

PROJECT_TERMS: Abdominal Pain;Acceleration;Adult;Affect;Aftercare;Biological;Biological Markers;Blood capillaries;Brain;burden of illness;Cell Proliferation;Characteristics;Child;chronic inflammatory disease;Clinical;clinical decision-making;Clinical Markers;clinical practice;clinical remission;Coin;Compensation;Computer software;contrast enhanced;Contrast Media;Crohn's disease;deep learning;deep learning model;density;Deposition;Diagnostic;diagnostic accuracy;Diffusion;Diffusion Magnetic Resonance Imaging;diffusion weighted;Digestive System Disorders;Disease;Disease Management;Disease remission;economic impact;efficacy evaluation;Endoscopy;Estimation Techniques;Evaluation;Fever;Gadolinium;Goals;gut inflammation;healing;Health Care Costs;Hemorrhagic colitis;Hospital Costs;Hospitalization;Image;Image Analysis;Image Enhancement;imaging biomarker;imaging modality;imaging software;Imaging Techniques;Immunomodulators;improved;indexing;Individual;individual patient;individualized medicine;Inflammation;Intestines;Ionizing radiation;Laboratory Markers;Machine Learning;Magnetic Resonance;Magnetic Resonance Imaging;Malaise;Maps;Measurement;Methods;Modeling;molecular marker;Monitor;Morphologic artifacts;Motility;Motion;Mucous Membrane;novel;open source;Operative Surgical Procedures;Outcome;Parameter Estimation;Patient Outcomes Assessments;Patients;Perfusion;Pharmaceutical Preparations;Physiological;Predisposition;Prevalence;Procedures;Protocols documentation;Quality of life;quantitative imaging;Radiation;Relapse;Reporting;Reproducibility;Respiration;response;response biomarker;Safety;Slice;soft tissue;software development;Software Tools;Standardization;Structure;success;Symptoms;Techniques;Testing;Time;Tissues;tool;Treatment Efficacy;treatment response;treatment strategy;water diffusion

PROJECT_TITLE: Robust quantitative MR imaging markers of response to therapy in Crohn’s Disease

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Agent Orange & Dioxin;Behavioral and Social Science;Clinical Research;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health

PHR: Project Narrative: The Community Engagement Core will serve as the communication conduit with local residents, opinion leaders, key informants and CBOs in target communities. CEC will mplement primary and secondary prevention activities to improve public health by reducing exposures to and toxicity from hazardous substances.

PI_NAMEs: CROISANT, SHARON A (contact)

PROJECT_TERMS: Address;Advocacy;Affect;Area;Aromatic Polycyclic Hydrocarbons;authority;Chemicals;Chronic Disease;Chronic lung disease;Cities;Clinic;Clinical;Collaborations;Communication;Communities;community engagement;community partners;community science;Complex;Consumption;Data;Dedications;Deer;Detection;Dioxins;early life exposure;Education;Educational Intervention;Educational workshop;Engineering;Environment;Environmental Health;Environmental Impact;environmental justice;experience;Exposure to;Fishes;Fostering;Furans;galena;Goals;Hazardous Substances;Health;Health Sciences;Hot Spot;Human;improved;Industrialization;Industry;informant;innovative technologies;Instruction;International;Intervention;Knowledge;Leadership;literacy;Long-Term Effects;Medicine;meetings;member;Mercury;Mexico;Mission;neglect;Neighborhoods;Neurocognitive Deficit;Neurodegenerative Disorders;new technology;Outcome;Output;outreach;Participant;Perception;Petroleum;Play;Policy Maker;pollutant;Pollution;Polychlorinated Biphenyls;Populations at Risk;Poverty;Predisposition;Pregnant Women;Premature Birth;prevent;Prevention;Prevention strategy;Primary Prevention;Process;programs;Public Health;remediation;Research;Research Personnel;Research Project Grants;Resources;Respiratory Disease;Risk;Risk Assessment;Role;screening;Secondary Prevention;Services;Signal Recognition Particle;Site;skills;Social Sciences;Soil;Stretching;Superfund;superfund site;Testing;Texas;Toxic effect;United States;Vulnerable Populations;wasting;Water;well water;Work

PROJECT_TITLE: Core B: Community Engagement Core (CEC)


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Human Genome;Liver Disease

ORG_CITY: LA JOLLA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Macrophages are essential for normal tissue homeostasis but also contribute to a diverse spectrum of metabolic diseases, including diabetes and non-alcoholic steatohepatitis. Studies proposed in this application will use a combination of genetic and genomic approaches to identify the signals that control homeostatic and pathogenic programs of gene expression in the macrophage populations of the mouse and human liver. Results from these studies will inform efforts to target macrophages for therapeutic purposes.

PI_NAMEs: GLASS, CHRISTOPHER K (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Automobile Driving;Binding;Biology;Bone Marrow;Bone Marrow Cell Transplantation;Cell Physiology;Cells;chronic inflammatory disease;combinatorial;Complex;Computing Methodologies;Desmosterol;Diabetes Mellitus;Disease;Enhancers;Environment;Environmental Risk Factor;Epigenetic Process;Evaluation;Exhibits;Funding;gene environment interaction;Gene Expression;genetic approach;Genetic Transcription;Genetic Variation;genome wide association study;Genomic approach;Grant;Health;Homeostasis;Human;human disease;Immune;In Vitro;Individual;Infection;Infiltration;Injury;Innate Immune System;insertion/deletion mutation;insight;Kupffer Cells;Link;Liver;Macrophage;Maps;Metabolic;Metabolic Diseases;Molecular;monocyte;mouse model;Mouse Strains;Mus;Myelogenous;Myeloid Cells;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;Normal tissue morphology;Pathogenicity;Pathologic;Phenotype;Play;Population;Population Heterogeneity;programs;recruit;risk variant;Role;sensor;Shapes;Signal Pathway;Signal Transduction;Specific qualifier value;Testing;Therapeutic;Tissues;transcription factor;transcriptome;transcriptomics;Untranslated RNA

PROJECT_TITLE: Transcriptional co-regulators and macrophage gene expression

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: LEE, CARRIE B (contact)

PROJECT_TERMS: Adherence;Administrator;Association of American Cancer Institutes;Attention;Budgets;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Catchment Area;Center for Translational Science Activities;Clinical;Clinical Cancer Center;Clinical Data;clinical development;Clinical Management;Clinical Protocols;Clinical Research;Clinical Sciences;clinical trial enrollment;Clinical Trials;Communication;community engagement;Community Outreach;Comprehensive Cancer Center;Conduct Clinical Trials;Contracts;Data;data management;Dedications;design;Development;Discipline;Disease;drug development;Economically Deprived Population;Enrollment;Ensure;Equity;ethnic minority;Faculty;faculty mentor;Fostering;Frequencies;Funding;Future;Genomics;Image;Immunotherapy;improved;Industry;innovation;Institutional Review Boards;Intervention;Intervention Trial;Knowledge;Leadership;life span;Link;member;Minority;minority health disparity;Minority Health Research;Minority Recruitment;Mission;Monitor;Monitoring Clinical Trials;Multicenter Trials;National Clinical Trials Network;North Carolina;novel;novel therapeutics;Observational Study;operation;participant enrollment;patient engagement;Patients;Performance;Phase;Physician Executives;Prevention;Preventive;programs;protocol development;Protocols documentation;Quality Control;racial minority;Regulatory Affairs;Reporting;Research;Research Design;Research Personnel;Research Training;Resources;Retrieval;Review Committee;Risk;Safety;Science;Services;Site;socioeconomic disadvantage;Specialist;Time;Training;treatment trial;UNC Lineberger Comprehensive Cancer Center;Underserved Population;Woman;Work;Writing

PROJECT_TITLE: Clinical Protocoal and Data Management


ORG_CITY: PHILADELPHIA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Narrative Enteric viruses are widespread but there are no specific therapeutics available. This proposal will dissect the molecular mechanisms that impact oral susceptibility to viral infection in the gut and will provide new insights into mechanisms at play, potentially leading to new therapeutic approaches to restrict enteric infections.

PI_NAMEs: CHERRY, SARA  (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Ablation;Age;Aging;Anabolism;Animal Model;animal old age;antiviral immunity;Apical;Autophagocytosis;Bacillus subtilis;Bacteria;bacterial community;Bacterial Infections;Binding;Biochemical;Biological Assay;body cavity;Bypass;Cells;commensal bacteria;Complement;cost;Coupled;Cytoplasm;Data;deletion library;Development;Dinucleoside Phosphates;Disease;Drosophila genus;dysbiosis;Enteral;enteric infection;enteric pathogen;enteric virus infection;Enterocytes;Epithelial Cells;Epithelium;feeding;fly;Gastrointestinal tract structure;Gene Deletion;gene product;Genes;Genetic Models;Genetic study;Homeostasis;Human;Immune;Immunity;Immunologics;Infection;Infection Control;insight;intestinal barrier;intestinal epithelium;Intestines;juvenile animal;Knowledge;life span;Ligands;Maintenance;microbial;microbiome;microbiota;model organism;Modeling;Molecular;mutant;NF-kappa B;novel strategies;novel therapeutic intervention;Nucleotides;Oral;Organism;pathogen;Pathogenesis;Pathway interactions;Pattern;Pattern recognition receptor;Periodicity;Permeability;Play;Predisposition;Probiotics;Refractory;Role;Shapes;Structure;TBK1 gene;Therapeutic;Vertebrates;Viral;Viral Physiology;Virus;Virus Diseases

PROJECT_TITLE: Defining the role of microbiota-derived cyclic dinucleotides in priming antiviral immune defenses.

STUDY_SECTION: GMPB

STUDY_SECTION_NAME: Gastrointestinal Mucosal Pathobiology Study Section[GMPB]


NIH_SPENDING_CATS: Endocrine Disruptors;Lung;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

PI_NAMEs: WENSEL, THEODORE G (contact)

PROJECT_TERMS: Area;Aromatic Polycyclic Hydrocarbons;Award;Bioinformatics;Biophysics;Cancer Center;career;career development;Childhood;Chronic lung disease;Clinical;Collaborations;college;Communication;Communities;community engagement;Complex;County;Data Analyses;data management;data sharing;Databases;Detection;Development Plans;digital data;Doctor of Medicine;early life exposure;Educational workshop;Engineering;Ensure;Environment;Environmental Health;Environmental Impact;Environmental Science;experience;Faculty;faculty mentor;Fellowship;fetal;Funding;Goals;graduate student;Grant;gulf coast;Health;Health Sciences;Individual;innovation;Institution;Interdisciplinary Study;Joints;Laboratories;large scale data;Medical;Medical center;Medical Research;Medicine;meetings;Mentors;Mentorship;Metadata;Mission;Molecular;National Institute of Environmental Health Sciences;Neurocognitive Deficit;next generation;Occupations;Office of Administrative Management;Outcome;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Premature Birth;Prevention;Program Research Project Grants;programs;Public Health Schools;Publications;Recording of previous events;remediation;Reproducibility;Research;Research Institute;Research Personnel;Research Project Grants;Research Project Summaries;Research Support;Research Training;Resources;Rice;Science;Scientist;Site;skills;Solid;Source;Statistical Data Interpretation;statistical learning;success;Superfund;superfund site;synergism;Teacher Professional Development;Technology;Technology Transfer;Texas;Training;training opportunity;Training Programs;Translational Research;Travel;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: Core C: Research Experience and Training Coordination Core (RETCC)


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: FORT COLLINS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative This project will increase our knowledge of the mechanisms and functions of chromatin, which has been implicated in the majority of cancers and in many genetic and developmental disorders. It will also investigate the mechanisms of cellular quiescence, which is a process that has been linked to conferring drug resistance to cancer cells. These studies will aid researchers in the field and have the potential to identify new targets for anti-cancer therapies.

PI_NAMEs: SWYGERT, SARAH GRACE (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: 3-Dimensional;anti-cancer research;Appearance;Base Pairing;Basic Science;Binding;Biochemical;Bioinformatics;Biological Assay;Biological Models;cancer cell;cancer drug resistance;cancer therapy;career;Cells;ChIP-seq;Chromatin;Chromatin Loop;Chromatin Modeling;Chromatin Structure;cohesin;Complex;condensin;CRISPR/Cas technology;Data;derepression;developmental disease;DNA;Electron Microscopy;electron tomography;Enhancers;Enzymes;experimental study;Fiber;Foundations;Fred Hutchinson Cancer Research Center;Gene Cluster;gene repression;Genes;Genetic Diseases;Genetic Transcription;genome-wide;Genomics;Histone Deacetylation;Histones;Human;human disease;interest;Knowledge;Link;Magnetism;Malignant Neoplasms;Maps;Mentors;Methods;Microscopy;Modeling;Molecular Conformation;nanometer;Nucleosomes;Physical condensation;Physiological;Positioning Attribute;Process;promoter;Repression;Research;Research Personnel;Resolution;Role;Saccharomyces cerevisiae;segregation;single molecule;skills;Structure;Supervision;System;Technology;Testing;three dimensional structure;Training;transcription factor;Transcriptional Regulation;Work;Yeasts

PROJECT_TITLE: Mechanisms and functions of repressive chromatin structure in quiescent cells.

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Endocrine Disruptors;Genetics;Human Genome;Lung;Mental Health;Neonatal Respiratory Distress;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Preterm, Low Birth Weight and Health of the Newborn;Prevention

PHR: Project Narrative  Pregnant women, living in the vicinity of superfund sites, who may be exposed to polyclic aromatic hydrocarbons (PAHs) that emanate from these sites, are at a higher risk for preterm delivery. We hypothesize that prenatal PAH exposure will exacerbate the effects of postnatal supplemental oxygen in preterm neonates. Accomplishments of the aims of this project should be beneficial to stakeholders such as EPA and ASTDR, as we will be able to extrapolate the doses we give in animals to humans who might be exposed to PAHs.

PI_NAMEs: EDWARDS, DEAN P (contact)

PROJECT_TERMS: analytical method;Animals;anti-cancer research;Antibodies;Aromatic Hydrocarbons;Aromatic Polycyclic Hydrocarbons;Award;Biological Assay;biomarker identification;biomarker signature;bisulfite sequencing;Bronchopulmonary Dysplasia;Cancer Center Support Grant;cancer prevention;ChIP-seq;Chromatin;Chronic lung disease;Clinical;Communities;Computers and Advanced Instrumentation;Consultations;Core Facility;Data;Data Analyses;data management;Data Set;design;Detection;Development;DNA Methylation;doctoral student;Dose;early life exposure;Educational workshop;Ensure;Enzymes;Epigenetic Process;epigenetic profiling;epigenomics;experience;Experimental Designs;Experimental Models;Exposure to;Faculty;Funding;Genetic;genome sequencing;genome-wide;genomic platform;Genomics;Goals;graduate student;Grant;high risk;histone modification;Human;Individual;Infrastructure;Institution;investigator training;Mass Fragmentography;Mass Spectrum Analysis;Measures;Mentors;Metabolic;metabolomics;Methods;Molecular;Molecular Profiling;multiple omics;neurobehavioral;Neurocognitive Deficit;novel;organizational structure;Outcome;Oxidation-Reduction;Phase;Postdoctoral Fellow;postnatal;Pregnant Women;Premature Birth;prenatal;preterm newborn;Prevention;Procedures;Progress Reports;Protein Array;Proteomics;Protocols documentation;remediation;Research;Research Institute;Research Personnel;Research Project Summaries;Research Support;Resources;Rice;Services;Signal Recognition Particle;Site;skills;Superfund;superfund site;supplemental oxygen;Techniques;Technology;technology platform;Training;training opportunity;transcriptome sequencing;transcriptomics;Validation;whole genome;Work

PROJECT_TITLE: Core D: Research Support Core


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PI_NAMEs: DA, YANG  (contact)

PROGRAM_OFFICER_NAME: ARGUELLO, ALEXANDER

PROJECT_TITLE: Genomic discovery and prediction for quantitative traits with complex genetic mechanisms


NIH_SPENDING_CATS: Clinical Research;Data Science;Endocrine Disruptors;Lung;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

PHR: Project narrative The Data Management and Analysis Core provides comprehensive and essential data management support, bioinformatics analysis, statistical consultation and assistance with education to Projects and Cores of the Superfund Research. It will implement a relatively simple but comprehensive Data Management Plan (DMP). The combined data analyses and integration have the potential to lead to novel mechanistic insights that would not be apparent to individual projects or cores.

PI_NAMEs: HILSENBECK, SUSAN G. (contact)

PROJECT_TERMS: Area;arm;Aromatic Polycyclic Hydrocarbons;Big Data;biobank;Bioinformatics;Biological;Biometry;Cancer Center;Chemicals;Chronic lung disease;Clinical;Code;Collaborations;Communities;Complex;Consultations;Data;Data Analyses;data centers;Data Coordinating Center;Data Engineering;data format;data integration;data management;data submission;deep learning;Detection;early life exposure;Education;Educational process of instructing;Educational workshop;Engineering;experience;FAIR principles;Funding;Galaxy;graduate student;Grant;Individual;informatics shared resource;Information Management;Infrastructure;insight;Journals;Laboratories;learning progression;Life Cycle Stages;Malignant Neoplasms;meetings;member;metabolomics;Metadata;Methods;Monitor;multidisciplinary;Multiomic Data;multiple omics;Neurocognitive Deficit;novel;Outcome;Phenotype;Policies;Postdoctoral Fellow;Premature Birth;Prevention;Process;Program Research Project Grants;programs;Proteomics;quality assurance;remediation;repository;Reproducibility;Research;Research Methodology;Research Personnel;Resources;Rice;Role;Sampling;secondary analysis;sharing platform;statistics;STEM research;success;Superfund;symposium;Technology;Testing;tool;Training and Education;user-friendly;web portal;Work

PROJECT_TITLE: Core E: Data Management and Analysis Core (DMAC)


ADMINISTERING_IC: MH

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Sleep Research;Social Determinants of Health;Women's Health Research

ORG_CITY: KENNESAW

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: KENNESAW STATE UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Relevance to Public Health An important and previously largely unaddressed issue in Sub-Saharan Africa, and in Uganda specifically, is what may mitigate the role of social drivers, such as poverty, in the pathway to mental illness among youth. Past research shows that socioeconomic strengthening is key to address poverty in low resource settings. Our project will examine if socieeconomic strengthening, primarily through vocational skills training, will prevent or reduce mental illness among adolescent girls and young women who live in urban slums in Kampala, Uganda.

PI_NAMEs: SWAHN, MONICA H (contact)

PROGRAM_OFFICER_NAME: CAMPBELL-ROSEN, HOLLY RENEE

PROJECT_TERMS: Acute;Address;Adverse effects;Africa South of the Sahara;Age;Alcohols;alpha-amylase;Anxiety;Arousal and Regulatory Systems;Award;Budgets;Buffers;Clinical Trials;cohort;Cohort Studies;Collaborations;Communities;community intervention;community organizations;Complex;conditioned fear;dehydroepiandrosterone;design;Development;diaries;Disease;Employment;empowerment;Enrollment;environmental stressor;Evaluation;experience;Female Adolescents;fitbit;Focus Groups;follow-up;Future;Hormones;Housing;Hydrocortisone;improved;Infrastructure;Intervention;intervention delivery;intervention program;Link;Location;Longterm Follow-up;Maps;Measures;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Methods;Modeling;National Institute of Mental Health;Negative Valence;Neighborhoods;operation;Outcome;Participant;Pathway interactions;Patient Self-Report;Perception;Physiological;Population;post intervention;Poverty;prevent;programs;prospective;Prospective cohort;Psychosocial Assessment and Care;Public Health;Radial;recruit;Research;Research Domain Criteria;resilience;Resource-limited setting;response;Role;Saliva;Salivary;Sampling;sensor;skills training;Sleep;sleep pattern;sleep quality;Slum;social;social determinants;social stressor;socioeconomics;Stress;stressor;substance use;suicidal;Surveys;Symptoms;Tablets;Testing;Time;Training;Training Programs;Uganda;Universities;urban setting;Vocation;Wakefulness;wearable device;wearable sensor technology;Work;young woman;Youth

PROJECT_TITLE: TOPOWA Study: Social Drivers of Mental Illness among AGYW in Slums.


NIH_SPENDING_CATS: Bioengineering;Endocrine Disruptors;Lung;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

PHR: Project narrative  The goal of this project is to achieve detection sensitivities similar to analytical techniques such  as GC-MS, using new, nanoengineering-based approaches to chemical detection and  identification of PAHs and PACs based on surface-enhanced vibrational spectroscopies.  Combining the optically active nanoengineered substrates with ultracompact photocurrent  detection technology, could greatly facilitate and accelerate the evaluation of superfund sites  and their environmental and biological impact, and will also help in risk assessment by  partnering with EPA and ATSDR.

PI_NAMEs: HALAS, NAOMI  (contact)

PROJECT_TERMS: absorption;Acceleration;Address;adhesive protein (mussel);Adsorption;Air;air sampling;Algorithms;Aluminum;Aromatic Compounds;Aromatic Polycyclic Hydrocarbons;automated algorithm;Biological;Biomimetics;Carcinogens;Chemicals;Chronic lung disease;Classification;Clinic;Clinical;Complex;Complex Mixtures;convolutional neural network;cost;design;Detection;detection limit;detection method;detection platform;detection sensitivity;detection test;detector;Development;Devices;early life exposure;Electromagnetics;Electronics;enhancing factor;Environment;Evaluation;exposed human population;Exposure to;fabrication;Family;Friends;Geometry;Goals;Gold;hazard;Health;Health Hazards;Human;Hydroxyl Radical;improved;infrared spectroscopy;innovation;instrumentation;intercalation;interest;invention;Laboratories;learning algorithm;learning strategy;Libraries;Liquid substance;Machine Learning;machine learning algorithm;machine learning model;Manuals;Mass Fragmentography;metallicity;Methods;Modeling;Molecular;Molecular Structure;Monitor;monolayer;Mutagens;nano;nanoengineering;nanofabrication;nanoparticle;nanosensors;Nanostructures;Neurocognitive Deficit;novel strategies;Optics;Outcome;Parents;Patient Monitoring;Polymers;Population;Premature Birth;Preparation;Prevention;prototype;Raman Spectrum Analysis;remediation;Research;response;Risk;Risk Assessment;Sampling;Signal Transduction;Silicon;Silver;Soil;soil sampling;Spectrum Analysis;Structure;superfund site;Surface;Techniques;Technology;Testing;Time;tool;Training;Variant;Water;water sampling;waterborne;Work

PROJECT_TITLE: Project 1: Streamlined identification of PAHs/PACs in environmental samples using ultracompact spectroscopy platforms and machine learning strategies


NIH_SPENDING_CATS: Cancer;Patient Safety

PI_NAMEs: MCREE, AUTUMN J (contact)

PROJECT_TERMS: Address;Advocate;African American population;Area;authority;Basic Science;Biometry;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Cancer Patient;Catchment Area;Clinical Data;Clinical Protocols;Clinical Research;Clinical Research Protocols;Clinical Sciences;Clinical Trials;clinically relevant;Committee Members;Communities;community engagement;Community Outreach;Consent;cost effective;data management;Data Management Resources;Dedications;Discipline;Disease;Ensure;Environment;Evaluation;Faculty;feasibility trial;Funding;Future;Goals;Growth;Human Research Ethics;improved;Infrastructure;Institutional Review Boards;Intervention;investigator-initiated trial;Laboratories;Leadership;Learning;Malignant Neoplasms;meetings;member;Mentors;Minority;Monitor;North Carolina;Online Systems;Patients;Population;Population Sciences;Preparation;Problem Solving;Process;Protocols documentation;recruit;Research;Research Personnel;Resources;Review Committee;Role;Social Sciences;System;Time;Training and Education;UNC Lineberger Comprehensive Cancer Center;Underrepresented Minority;Universities;Voice

PROJECT_TITLE: Protocol Review and Monitoring System


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Endocrine Disruptors;Genetics;Human Genome;Lung;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

PHR: Project Narrative The morbidity and mortality of preterm birth is astounding; however, little to no data exists on the cause. The research outlined in this proposal aims to garner mechanistic insight into the association between PAH exposure, proximity to Superfund sites and preterm birth through transcriptomics and epigenomics.

PI_NAMEs: AAGAARD, KJERSTI MARIE (contact)

PROJECT_TERMS: adduct;adverse pregnancy outcome;Aromatic Polycyclic Hydrocarbons;Automobile Driving;Biological Assay;Biological Markers;Body mass index;Cells;Chemicals;Chronic lung disease;Clinical;cohort;Collaborations;comorbidity;County;Data;Detection;DNA Adducts;DNA Methylation;Dose;early life exposure;Environmental Exposure;epigenomics;Ethnic Origin;Etiology;experimental study;Exposure to;Gene Expression;genome sciences;genome-wide;Geographic Information Systems;Gestational Age;improved;In Vitro;information system analysis;insight;Label;Maps;Mass Fragmentography;Maternal Age;Maternal and Child Health;Measurable;Measures;Mediating;Metagenomics;Methods;Modeling;Molecular;Monitor;monitoring device;Morbidity - disease rate;mortality;Neurocognitive Deficit;Outcome;perinatal morbidity;Perinatal mortality demographics;Phase;Placenta;population based;Predisposition;Pregnancy;Pregnant Women;Premature Birth;Prevention;Prospective cohort;Race;recruit;remediation;Reporting;Research;residence;Retrospective cohort;Rice;Risk;Role;Sampling;Serum;Signal Recognition Particle;Silicones;Smoking;Soil;Solid;superfund site;Term Birth;Third Pregnancy Trimester;Time;Tissues;transcriptome sequencing;transcriptomics;trophoblast;Very Low Birth Weight Infant;wearable device;Woman;Women's cohort;wristband

PROJECT_TITLE: Project 2: Investigating the role of PAH exposures associated with superfund site proximity in preterm birth etiology through placental transcriptomics and metagenomics


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: MEMPHIS

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: In this imaging genetics project we quantify impact of human Alzheimer's disease (AD) transgenes on brain structure and memory function (magnetic resonance imaging, light-sheet microscopy) using a diverse cohort of AD-BXD lines. This approach gets at the molecular and cellular causes of AD and in the severity of cognitive loss and memory function. We link data and findings to matched genomic and imaging data on human AD and cognition. .

PI_NAMEs: JOHNSON, GEORGE ALLAN;WILLIAMS, ROBERT W. (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Age;Age Months;age related;Age-associated memory impairment;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease model;Behavioral;biobank;Brain;brain magnetic resonance imaging;Candidate Disease Gene;cell type;Cells;Cognition;Cognitive;Cognitive aging;cohort;Collaborations;Communities;Complex;conditioned fear;connectome;Data;data integration;data modalities;Data Set;Databases;design;DNA;empowerment;endophenotype;Error Sources;Etiology;Exposure to;FAIR principles;familial Alzheimer disease;Family;fear memory;Female;functional decline;Functional disorder;Functional Magnetic Resonance Imaging;Future;gene network;Genes;Genetic;genetic testing;genetic variant;Genetic Variation;Genome;genome wide association study;Genomics;Genotype-Tissue Expression Project;Grain;Heritability;high throughput analysis;Hippocampus;Human;Hybrids;Image;imaging genetics;imaging program;Immunohistochemistry;Impaired cognition;improved;Inflammation;Informatics;insight;Internet;Intervention;Knowledge Portal;Late Onset Alzheimer Disease;Left;Light;Link;Magnetic Resonance Imaging;male;Maps;Measures;Memory;Memory Loss;memory process;Methods;Microscopy;Mitochondria;Modeling;Molecular;mouse model;Mus;Neocortex;Neuroanatomy;Neurocognitive Deficit;neurogenetics;neuron loss;Noise;normal aging;Pathology;Pharmacotherapy;phenome;Phenotype;Population;Pre-Clinical Model;Preclinical Testing;Predisposition;Prevention;Process;protein aggregation;Proteome;Protocols documentation;Research;resilience;Resolution;Rest;Services;Severities;Severity of illness;sex;Stress;Structure;success;Synapses;System;Techniques;Testing;therapeutic target;Time;tool;transcriptome sequencing;Transgenes;Transgenic Mice;Transgenic Organisms;Translating;Variant;web services;whole genome;Work

PROJECT_TITLE: Imaging Genetics of Brain Structure and Cognitive Aging in Murine  Models of Alzheimer's Disease


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Lung;Prevention;Social Determinants of Health

PHR: A major global health threat is the growing combination of HIV, chronic diseases, urbanization, and air pollution. This study will follow people as they migrate from rural settings into cities and track their health outcomes and potentially related factors such as air pollution levels and health care access. Results from this study will help to develop strategies to better care for persons with HIV and chronic diseases as they live in increasingly urbanized and polluted settings.

PI_NAMEs: CHANG, LARRY WILLIAM (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, MAKEDA J

PROJECT_TERMS: 2019-nCoV;Adult;Africa;African;Age;Air;Air Pollution;Alcohol consumption;antiretroviral therapy;Asthma;Blood Pressure;Body mass index;Carbon Black;Carbon Monoxide;Cardiac;Cardiopulmonary;Caring;Censuses;Chronic;Chronic Disease;Chronic Obstructive Pulmonary Disease;Cities;Clinical;cohort;Cohort Studies;combat;Communities;comparison group;Congestive Heart Failure;Creatinine;Data;demographics;design;Diet;Disease;disorder risk;Echocardiography;Environment;Epidemic;Epidemiology;experience;Exposure to;fine particles;Future;global health;Glycosylated hemoglobin A;Health;health assessment;health care availability;Health care facility;health care service utilization;health determinants;health service use;Health Services;HIV;HIV Infections;HIV Seronegativity;HIV Seropositivity;Hour;Hypertension;improved;Inflammation;Infrastructure;innovation;Intervention;Life Style;Longitudinal cohort study;Lung;Lung infections;Migrant;migration;Morbidity - disease rate;mortality;novel;Out-Migrations;Outcome;Participant;Pattern;Persons;Pharmaceutical Preparations;Physical activity;Policies;Pollution;Population;Population Attributable Risks;population based;Population Research;Predisposition;Prevalence;Prevention;programs;Regimen;Research;Research Infrastructure;Risk Factors;Role;Rural;Rural Community;rural setting;rural-urban migration;sex;social;Spirometry;Surveys;syndemic;Tobacco use;Tuberculosis;Uganda;urban area;urban setting;Urbanization;Ventricular;Viremia;World Health Organization

PROJECT_TITLE: Epidemiology and Impact of the HIV, NCD, and Urbanization Syndemic in Africa

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Childhood Injury;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Endocrine Disruptors;Genetics;Infant Mortality;Lung;Mental Health;Neonatal Respiratory Distress;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

PHR: Project Narrative  Pregnant women, living in the vicinity of superfund sites, who may be exposed to polycyclic aromatic hydrocarbons (PAHs) that emanate from these sites, are at a higher risk for preterm delivery. We hypothesize that prenatal PAH exposure will exacerbate the effects of postnatal supplemental oxygen in preterm neonates. Accomplishments of the aims of this project should be beneficial to stakeholders such as EPA and ASTDR, as we will be able to extrapolate the doses we give in animals to humans who might be exposed to PAHs.

PI_NAMEs: MOORTHY, BHAGAVATULA  (contact)

PROJECT_TERMS: A549;Age;Air;Alveolar;Animals;Anthracenes;Aromatic Polycyclic Hydrocarbons;aspirate;Benzo(a)pyrene;Biological Assay;Birth Rate;Bronchopulmonary Dysplasia;Carcinogens;Cells;Chemosensitization;Chronic lung disease;Clinical;Collaborations;Corn Oil;CYP11A1 gene;CYP1A1 gene;Cytochrome P450;Data;Detection;DNA;DNA Adducts;DNA lesion;Dose;early life exposure;Environmental Health;Enzymes;Epigenetic Process;epigenomics;Etiology;Exhibits;experimental study;exposed human population;Exposure to;EZH2 gene;Genes;genotoxicity;high risk;Human;Hyperoxia;In Vitro;in vivo;Infant;insight;Label;Life;Lung;lung injury;Mass Fragmentography;Methylation;Molecular;Morbidity - disease rate;Mothers;Mus;neonatal lung injury;neonatal mice;neonate;neurobehavioral;neurobehavioral test;Neurocognitive Deficit;Newborn Infant;novel strategies;Oral;Outcome;Oxygen;Parents;Pathway interactions;Placenta;postnatal;Precision Health;Predisposition;Pregnancy;pregnant;Pregnant Women;premature;Premature Birth;Premature Infant;prenatal;prenatal exposure;preterm newborn;prevent;Prevention;Prevention strategy;Probability;professor;Pyrenes;remediation;Research Support;Retrospective Studies;Risk;Role;RUNX3 gene;sample archive;Site;superfund site;supplemental oxygen;Testing;Toxic effect;Toxicity Attenuation;Trachea;transcriptome sequencing;transcriptomics;Umbilical Cord Blood;Weaning;Wild Type Mouse;Woman

PROJECT_TITLE: Proj3:Role of cytochrome P450 (CYP)1A/1B1 enzymes in the potentiation of neonatal lung injury in newbron mice exposed prenatally to PHs, and increased risk of premature infants to chronic lung disease


ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: There is a strong relationship between adipose tissue and the onset of diseases such as Type 2 Diabetes and heart disease, and one of the most important factor seems to be the type of fat each individual carries. There is a type of fat called “beige” fat that has the capacity to burn calories and secrete hormones that improve metabolism. Individuals who have more “beige” fat are protected from developing diabetes and heart disease. The genes responsible for making this type of fat are not known, but our studies find that a one of them is a special gene that doesn’t code for a protein. This gene, called LINC00473, may be an organizer of proteins that help burn fat in the mitochondria. We believe that understanding the function of this gene can help us understand how beige fat forms, and how it functions to improve metabolism. It may also help us recapitulate the beneficial effects if beige fat in ways that can improve health.

PI_NAMEs: CORVERA, SILVIA  (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: adipocyte differentiation;Adipocytes;Adipose tissue;Affect;Affinity;Alleles;angiogenesis;Biochemical;blood glucose regulation;Calories;Cell Nucleus;Cell Respiration;Cells;Code;Complex;crosslink;Cytoplasm;Development;Diabetes Mellitus;Diagnostic;experimental study;fat burning;Fatty acid glycerol esters;Fatty Acids;Feedback;Funding;gene function;Genes;genetic regulatory protein;Genetic Transcription;glucose metabolism;Goals;Growth;Health;Heart Diseases;high resolution imaging;Homeostasis;Hormone secretion;Human;Image;Impairment;improved;in vivo;Individual;Interphase;Kinetics;knock-down;Label;Lipids;Lipolysis;Mass Spectrum Analysis;Mediating;Mesenchymal Stem Cells;Metabolic;Metabolic Diseases;Metabolism;Mitochondria;Mitochondrial Proteins;Modeling;Molecular;Mus;mutant;Nature;nerve supply;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;Obesity;Onset of illness;overexpression;oxidation;Pathway interactions;physiologic model;Physiological;Primates;protein complex;protein protein interaction;Proteins;Repression;Research;Respiration;RNA;RNA-Protein Interaction;Role;Stimulus;Synapses;Techniques;Testing;therapeutic target;transcriptomics;Transplantation;Untranslated RNA;Vascularization;Work

PROJECT_TITLE: Adipose Tissue Angiogenesis and Metabolic Disease

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]


NIH_SPENDING_CATS: Contraception/Reproduction;Endocrine Disruptors;Lung;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

PHR: Project Narrative This project will develop a sustainable remediation technology to rapidly treat sediments and soils contaminated with polycyclic aromatic hydrocarbons (PAHs) and related polyaromatic compounds (PACs), including activated PAHs byproducts of environmental transformations, in a manner that completely removes the associated health risks while adding value to the impacted media. Our hypothesis is that pyrolysis of contaminated soils/sediments under carefully selected conditions will reduce the concentration of all organic priority contaminants to below regulatory levels, thus completely eliminating toxicity, while restoring soil fertility to facilitate ecosystem restoration and re-greening efforts. Thus, the proposed studies will build on our recent discovery that pyrolysis can add value to soil contaminated with petrochemical wastes (including heavy petroleum hydrocarbons) by converting these pollutants to char-like material.

PI_NAMEs: ALVAREZ, PEDRO J (contact)

PROJECT_TERMS: Affect;Agriculture;Aromatic Polycyclic Hydrocarbons;Carbon;chemical stability;Chemicals;Chemistry;Chronic lung disease;clay;Clinical;contaminated sediment;cost;cost effective;cost efficient;density;Detection;Drainage procedure;Drug Metabolic Detoxication;early life exposure;Ecosystem;Ensure;Excision;Fertility;fertility improvement;Gases;Germination;Health;Hydrocarbons;Hydrophobicity;Image;implementation cost;improved;innovation;lipophilicity;Mass Spectrum Analysis;Measures;Neurocognitive Deficit;new technology;Nitrogen;Outcome;Petroleum;Phosphorus;Plants;pollutant;Porosity;Premature Birth;Prevention;Process;Property;Reaction;Recovery;remediation;Research Project Grants;residence;restoration;Risk;Roentgen Rays;Salvelinus;Soil;Solid;Spatial Distribution;Spectrum Analysis;superfund site;Surface;Techniques;technological innovation;Technology;Temperature;Testing;Thermogravimetry;Time;Toxic effect;Volatilization;wasting;Water;Work

PROJECT_TITLE: Project 5: Pyolytic conversion of PAHs in contaminated sediments into char to eliminate toxicity and enhance soil fertility


NIH_SPENDING_CATS: Aging;Atherosclerosis;Bioengineering;Biomedical Imaging;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Narrative Atherosclerosis imaging remains a clinical challenge due to its complex biology and the dynamic expression of targets during disease evolution. Chemokines and their receptors, play a key role in the immune cell trafficking and activation that underlie inflammatory responses of human disease and are thus an attractive target for new therapies and imaging approaches. The availability of imaging tools that could help to better understand chemokine biology in human disease pathogenesis, laying the foundation for new diagnostic and treatment paradigms and ultimately, improved human health. This submission will develop novel imaging agents targeting chemokine receptors and other disease-relevant targets in atherosclerosis and assess their potential for translation. The success of this program will not only build an “imaging tool box” for atherosclerosis, but also a model of probe development and translation for broader applications to other diseases within the NHLBI mission.

PI_NAMEs: LIU, YONGJIAN  (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Accounting;Affinity;Arterial Fatty Streak;Atherosclerosis;Binding;Biocompatible Coated Materials;Biodistribution;Biology;Cardiovascular Diseases;CCR5 gene;CD44 gene;Cells;Characteristics;Charge;Chemistry;chemokine;chemokine receptor;Clinical;Complex;Complication;CXCR3 gene;design;Detection;Development;Disease;Event;Evolution;Foundations;Future;Grant;Health;high risk;Human;human disease;Image;image translation;imaging agent;imaging approach;Imaging Device;imaging probe;Immune;improved;improved outcome;in vivo;Inflammatory;Inflammatory Response;Investigational New Drug Application;Leukocyte Trafficking;Lipids;Mission;Modeling;Molecular Probes;Molecular Target;monocyte;mouse model;Myocardial Infarction;National Heart, Lung, and Blood Institute;new therapeutic target;novel;novel diagnostics;Oryctolagus cuniculus;Pathogenesis;Patient-Focused Outcomes;Patients;Peripheral arterial disease;plaque lesion;Play;Polymers;Positron-Emission Tomography;programs;Progressive Disease;Radiochemistry;Radiolabeled;receptor;Research;Role;scale up;Specificity;Stroke;success;Surface;targeted agent;Tissues;TLR2 gene;Tracer;trafficking;translational potential;Translations;treatment response

PROJECT_TITLE: Targeted Molecular Probes for Atherosclerosis Imaging and Therapy


NIH_SPENDING_CATS: Cancer

PI_NAMEs: DARR, DAVID  (contact)

PROJECT_TERMS: Acceleration;Benchmarking;biomedical resource;Biometry;Budgets;Cancer Center Support Grant;Charge;Complement;Comprehensive Cancer Center;cost effective;Data;Ensure;Equipment;equipment acquisition;experience;Faculty;Feedback;Fees;Funding;Human Resources;Individual;Infrastructure;innovation;Institution;instrumentation;Investments;Leadership;Maps;medical schools;meetings;member;new technology;operation;Pathology;peer;Police;Process;programs;Recording of previous events;recruit;Reproducibility;Research;Resource Sharing;Resources;Respondent;Schools;Science;Services;single cell analysis;Source;statistics;Strategic Planning;Surveys;technique development;Technology;Tissues;tool;Training;Training and Education;training opportunity;Work

PROJECT_TITLE: Shared Resource Management


PHR: PROJECT NARRATIVE: Administrative Core  The major goal of the Iowa Superfund Research Program Administrative Core is to maintain a structure that:  1) promotes integration of research; 2) enables timely communication and research translation that raises the  quality and impact of center activities; and 3) provides vision and direction to ensure the center’s continued  success in conducting outstanding research stakeholder engagement. The Administrative Core provides  administrative and fiscal services, support, and oversight to ensure robust stewardship of available resources.

PI_NAMEs: HORNBUCKLE, KERI C (contact)

PROJECT_TERMS: Administrator;Adolescent;Advisory Committees;Affect;Air;Area;Child;Communication;Communities;Data;Dedications;Development;dietary;diphenyl;Discipline;Educational workshop;Effectiveness;effectiveness evaluation;Engineering;Ensure;Environmental Engineering technology;Environmental Health;Environmental Science;Event;experience;experimental study;Feeds;Goals;Government Agencies;Hazardous Substances;Health;Home;Human;Information Dissemination;Infrastructure;innovation;Institution;International;Iowa;Leadership;meetings;Metabolic;multidisciplinary;nature center;Neurologic;new technology;news;Outcome;Pathway interactions;Periodicals;Positioning Attribute;Productivity;programs;Recommendation;remediation;Research;Research Personnel;Research Support;Resources;Risk;Schools;Science;Services;Signal Recognition Particle;social media;Source;Structure;success;Superfund;support tools;System;Technology Transfer;Toxic effect;Training;Translating;Translational Research;Vision;web app;webinar;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Mental Health;Neurodegenerative;Neurosciences;Pain Research;Prevention;Rehabilitation

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Up to 75% of older adults have at least some persistent pain, and older adults with chronic pain are two times more likely to also report early cognitive decline. Chronic pain and early cognitive decline exacerbate each other, placing individuals on a “disability spiral” or worsened physical, emotional, and cognitive functioning with incremental risk of ADRD. The purpose of the present investigation is to test the efficacy of a novel, theory informed multimodal mind body activity program to improve physical, emotional and cognitive functioning in older adults with chronic musculoskeletal pain and early cognitive decline. Through this study, we seek to solve the unmet need of lack of evidence-based treatments to address chronic pain in older adults with early cognitive decline through a feasible, acceptable and credible program, and ideally delay progression toward ADRD.

PI_NAMEs: RITCHIE, CHRISTINE S;VRANCEANU, ANA-MARIA  (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: acceptability and feasibility;actigraphy;active control;Address;Adherence;adverse event risk;Alzheimer disease prevention;Alzheimer's disease related dementia;Alzheimer's disease risk;Anxiety;Awareness;barrier to care;battery life;Behavior;Benchmarking;blind;Brain;Breathing;Bypass;Cellular Phone;chronic musculoskeletal pain;chronic pain;chronic pain management;clinical predictors;Clinical Trials;clinically relevant;Cognition;Cognitive;cognitive benefits;cognitive function;cognitive performance;cognitive reserve;comorbidity;Consent;Coping Skills;Data;Data Collection;digital;digital monitoring;disability;Education;Educational process of instructing;effective intervention;efficacy evaluation;efficacy testing;Emotional;emotional functioning;Enrollment;ethnic minority;Ethnic Origin;Evidence based program;Evidence based treatment;Exercise;experience;falls;feasibility trial;fitbit;follow-up;functional improvement;Funding;General Hospitals;Geriatrics;Goals;Health;high risk population;Hip region structure;Impaired cognition;improved;Individual;Infrastructure;Intervention;intervention delivery;Interview;Investigation;Link;Massachusetts;Measures;Mediating;Mediator;Mental Depression;Methodology;Methods;mind/body;mindfulness;Modeling;monitoring device;multidisciplinary;multimodality;National Center for Complementary and Integrative Health;Neurobehavioral Manifestations;Nonpharmacologic Therapy;normal aging;novel;older adult;Outcome;Pain;pain catastrophizing;Pain intensity;Pain management;pain symptom;Participant;participant retention;Patient Self-Report;Patients;Performance;Persistent pain;Pharmaceutical Preparations;Physical Function;Population;pre-clinical;primary outcome;programs;Psychology;Race;racial minority;Randomized;Reaction;recruit;reinforcer;Reporting;Respiratory Diaphragm;response;Scanning;secondary outcome;side effect;Single-Blind Study;skills;slow potential;Strategic Planning;Stress and Coping;Technology Assessment;Testing;theories;uptake;virtual;virtual delivery;Walking;Wrist

PROJECT_TITLE: Addressing the chronic pain-early cognitive decline comorbidity among older adults; The Active Brains study

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Cancer;Cardiovascular;Heart Disease

ORG_CITY: PULLMAN

ORG_DEPT: PHARMACOLOGY

ORG_NAME: WASHINGTON STATE UNIVERSITY

PHR: PROJECT NARRATIVE Cancer chemotherapy significantly increases the risk of heart disease. This proposal will investigate the mechanisms of chemotherapy-induced heart toxicity, with a particular focus on the emerging role of the cell cycle machinery. Our research could lead to a more effective and less toxic chemotherapy regimen for cancer treatment.

PI_NAMEs: CHENG, ZHAOKANG  (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Ablation;Adult;Allografting;Anthracycline;Antineoplastic Agents;Apoptosis;Apoptotic;Biological Models;Biological Process;Birth;Cancer Patient;Cancer Survivor;cancer therapy;cancer type;Cardiac;Cardiac Myocytes;Cardiomyopathies;cardioprotection;Cardiotoxicity;CDK2 gene;Cell Cycle;Cell Cycle Progression;Cell Cycle Proteins;Cell Cycle Regulation;Cell Proliferation;Cells;Cessation of life;chemotherapy;Chemotherapy-Oncologic Procedure;Data;DNA Damage;DNA Double Strand Break;Doxorubicin;effective therapy;Foundations;gain of function;Genetic Transcription;Genetically Engineered Mouse;Heart;heart damage;heart disease risk;Heart failure;Immunocompetent;improved;In Vitro;in vivo;Induction of Apoptosis;Injury;innovation;Knockout Mice;Life Expectancy;loss of function;Mediating;Mediator;Modeling;Modernization;Morbidity - disease rate;mortality;mouse model;Mus;Muscle Cells;new therapeutic target;novel;patient prognosis;Phenotype;Phosphorylation;Phosphotransferases;Population;postmitotic;prevent;pro-apoptotic protein;protein expression;Proteins;Publishing;RBL2 gene;Reporting;Repression;Research;Role;success;System;Testing;Topoisomerase;Toxic effect;translational potential;Treatment-Related Cancer;tumor;United States;Work

PROJECT_TITLE: Cell cycle proteins as key regulators of cardiac chemosensitivity

STUDY_SECTION: MIM

STUDY_SECTION_NAME: Myocardial Ischemia and Metabolism Study Section[MIM]


NIH_SPENDING_CATS: Data Science;Endocrine Disruptors;Networking and Information Technology R&D (NITRD)

PHR: PROJECT NARRATIVE: Data Management and Analysis Core  The Data Management and Analysis Core (DMAC) is a proposed new core designed to support the specific  data management and analysis needs of Iowa Superfund Research Program (ISRP) projects and cores.  DMAC’s primary objective will be to apply biostatistics, informatics, and data management to support and  optimize the ISRP scientific research process, training, and methods to maximize research outcomes, applied  solutions, replicable products, and sound evidence-based decision support. DMAC will provide expert staff,  infrastructure, services, software, and research support and synthesis in order to achieve these goals.

PI_NAMEs: WANG, KAI  (contact)

PROJECT_TERMS: Address;Alkanesulfonates;analytical method;Appointment;Biological Markers;Biometry;Censuses;Code;Communication;Complex;Computer software;cost;cost effective;Data;Data Analyses;Data Analytics;data integration;data management;Data Science;design;Detection;Development;Development Plans;dimension reduction;Educational workshop;Ensure;Environment;Environmental Health;Event;evidence base;experience;Exposure to;Faculty;FAIR principles;Foundations;Goals;Health;Health Policy;Heavy Metals;Human;improved;in silico;In Vitro;in vivo;Individual;Informatics;Infrastructure;innovation;Instruction;Interdisciplinary Study;Investigation;Iowa;Journals;Lead;Measurement;Measures;Metabolic;metabolomics;Methods;New Territories;novel;Outcomes Research;Policies;Polychlorinated Biphenyls;Population;Process;Program Research Project Grants;programs;Protocols documentation;public repository;Publications;Publishing;quality assurance;Readability;remediation;repository;Reproducibility;Research;Research Design;Research Personnel;Research Support;Resources;Risk;Risk Assessment;Sampling;school district;School-Age Population;Science;Services;Signal Recognition Particle;software development;sound;Source;Statistical Data Interpretation;Statistical Methods;Students;Superfund;superfund chemical;Technology;tool;Toxic effect;Toxicology;Training;Training Activity;Uncertainty;United States National Institutes of Health;Universities;Visualization;Work

PROJECT_TITLE: Data Management and Analysis Core


NIH_SPENDING_CATS: Clinical Research;Endocrine Disruptors;Health Effects of Indoor Air Pollution;Pediatric;Prevention

PHR: NARRATIVE: Community Engagement Core  The ISRP Community Engagement Core will inform current and future interventions in school buildings that  will decrease airborne PCB exposures for school-aged children and staff. This is a clear need as articulated by  the East Chicago, IN, school district superintendent, a key project stakeholder. This project will also address  the community-identified need to reduce obesity in school-aged children in Columbus Junction and West  Liberty, IA.

PI_NAMEs: WATKINS, SHANNON LEA (contact)

PROJECT_TERMS: Address;Adipocytes;Agreement;air sampling;Articulation;Back;Behavioral;Cell Culture Techniques;Chicago;Child;cohort;Cohort Studies;Collection;Communication;Communities;community advisory board;community engagement;community involvement;community partners;contaminated sediment;Data;Data Discovery;Data Reporting;design;Development;education resources;Educational workshop;environmental change;Excision;experimental study;exposure reduction interventions;Exposure to;Freedom;Future;Gases;Goals;Harvest;Health;Health Campaign;Home;Human;improved;in vivo Model;indoor air;Indoor environment;Information Resources;Inhalation;innovation;Intervention;Iowa;Laboratories;Lighting;Link;lipid biosynthesis;Location;Measures;meetings;member;Metabolic syndrome;Modeling;Modernization;neurotoxic;novel;Obesity;Outcome;Paint;Parents;Participant;Personal Satisfaction;Persons;Phase;Pigments;Polychlorinated Biphenyls;Population;prevent;prospective;Public Health;remediation;Reporting;Research;Research Personnel;Research Project Grants;Risk Assessment;Sampling;school district;School-Age Population;Schools;Series;Source;statistics;Students;superfund chemical;superfund site;teacher;Technology;Testing;Time;Toxic effect;United States;United States Environmental Protection Agency;Universities;Varnish;Work

PROJECT_TITLE: Community Engagement Core


ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: NARRATIVE Cognitive aging has tremendous public health importance, but to our knowledge no Superfund Center addresses this outcome and it is not considered in risk assessment and risk management efforts. Our innovative Superfund Center not only tests the novel hypothesis that early life is a critical window for exposures that impact late-life cognitive health, but it also offers novel engineering solutions to remediate metal contamination. Our MEMCARE- SRC will lead to reductions in exposures to metals and metal mixtures and could help develop new prevention and treatment strategies that slow cognitive aging in Superfund communities affected by heavy metal contamination.

PI_NAMEs: LU, QUAN  (contact)

PROGRAM_OFFICER_NAME: CARLIN, DANIELLE J

PROJECT_TERMS: Address;Adult;Affect;Aging;animal old age;Behavior assessment;Benefits and Risks;Bioinformatics;Biological;Biomedical Research;Biometry;Boston;Brain;Child;Cognitive;Cognitive aging;cognitive function;Colorado;Communication;Communities;community collaboration;community engagement;cost;Data Analyses;data management;design;drinking water;early life exposure;Engineering;Ensure;Environment;Environmental Engineering technology;Environmental Science;Epigenetic Process;Evaluation;experience;extracellular vesicles;field study;Goals;ground water;Health;Heavy Metals;Human;human old age (65+);Hybrids;Impaired cognition;improved;in utero;In Vitro;in vivo;Industrialization;innovation;Intervention;late life;Life;Memory Loss;Metal exposure;metal poisoning;Metals;Methods;MicroRNAs;Modeling;Municipalities;Nanostructures;neurotoxic;novel;Organoids;Outcome;Pattern;pollutant;Population;Postdoctoral Fellow;postnatal;Predisposition;Prevention strategy;Privatization;programs;Public Health;Regulation;remediation;Reproducibility;Research;Research Project Grants;Resource Sharing;Risk;Risk Assessment;Risk Management;Role;Rural Community;Science;Source;Superfund;superfund site;Support System;Surface;System;Technology;Testing;Therapeutic;three dimensional cell culture;Tooth structure;toxicant;Training;treatment strategy;United States;Urban Community;Water;Water Supply;Work

PROJECT_TITLE: Metals and Metal Mixtures: Cognitive Aging, Remediation and Exposure Sources (MEMCARE)


NIH_SPENDING_CATS: Endocrine Disruptors;Prevention;Social Determinants of Health

PI_NAMEs: ANKRUM, JAMES ALLEN (contact)

PROJECT_TERMS: Affect;Air;Area;autism spectrum disorder;Biometry;Brain Diseases;career;career development;Catalogs;Chemicals;Collaborations;college;Communication;Communities;community engagement;Community Outreach;Complex;Data;Data Analyses;data management;data sharing;design;Detection;Development Plans;Dimensions;Discipline;Educational workshop;Engineering;Ensure;Environment;Environmental Engineering technology;Environmental Health;Environmental Pollutants;Environmental Pollution;Equipment;Ethics;experience;Exposure to;Faculty;Fertility;Funding;Future;Generations;Goals;graduate student;hazard;Hazard Identification;Health;hearing impairment;Human;immune system function;Individual;insight;interdisciplinary approach;Iowa;Knowledge;Laboratories;laboratory curriculum;large scale production;Leadership;Malignant Neoplasms;Medical;Medicine;meetings;Mentors;Metabolic syndrome;Methods;Microbiology;Modeling;multidisciplinary;Occupational Health;Pathway interactions;Pharmacology;Policies;pollutant;Polychlorinated Biphenyls;Postdoctoral Fellow;posters;prevent;Prevention;Program Research Project Grants;programs;remediation;Research;Research Methodology;Research Personnel;Research Technics;Resources;Risk;Risk Assessment;Role;Science;Scientist;skills;socioeconomics;Source;Specialist;student participation;Students;success;Superfund;Techniques;Technology;tool;Toxic effect;Toxicology;Training;Training Programs;Translational Research;Universities;urban planning;Vocational Guidance;Volatilization;Work

PROJECT_TITLE: Research Experience & Training Coordination Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PI_NAMEs: WEISSMAN, BERNARD E. (contact)

PROJECT_TERMS: Alleles;Animal Cancer Model;animal imaging;Animal Model;Animals;arm;Basic Science;Biological Assay;Breeding;Budgets;Cancer Center;Cancer Center Support Grant;cancer health disparity;cancer imaging;Cell Line;Cell Lineage;Cell Separation;Cells;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Consultations;cost;CRISPR/Cas technology;design;Development;Ensure;Event;experience;experimental study;Faculty;Funding;Gene Modified;Generations;Genetically Engineered Mouse;Genome;Genomic Segment;Histopathology;Human;Human Resources;Image;Image Analysis;Image Enhancement;image processing;imaging modality;imaging probe;Imaging technology;Immunocompetent;Immunocompromised Host;Immunohistochemistry;improved;in vivo;Inbred BALB C Mice;Individual;infrastructure development;innovation;Institution;Investigation;Knock-out;Laboratories;Malignant neoplasm of ovary;Malignant Neoplasms;member;Methods;Mission;Modeling;Modernization;Modification;mouse model;Mus;Nobel Prize;novel;Operative Surgical Procedures;Pathology;patient derived xenograft model;peer;Phenotype;pre-clinical research;Procedures;Production;Productivity;programs;Protocols documentation;radiologist;Rat Strains;Reagent;recombinase;Recording of previous events;Reporter Genes;Reproducibility;Research Personnel;Resource Sharing;Services;skills;Skin graft;Source;Stains;Standardization;Supervision;Techniques;Technology;Testing;tool;Training;Transgenic Organisms;Translational Research;tumor;Tumorigenicity;user-friendly;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Animal Models


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Depression;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Project Narrative  Many persons living with HIV/AIDS (PLWHA) are unemployed; unemployment results in lower quality of life, greater depression and substance use, and is associated with morbidity and mortality. Behavioral interventions can be applied alongside employment services best practices to improve outcomes. This study will evaluate standard and enhanced care to examine the efficacy of reinforcing job-acquisition activities for improving employment outcomes in PLWHA who desire to return to the workforce in part- or full-time capacity.

PI_NAMEs: RASH, CARLA J (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: Address;Anti-Retroviral Agents;Back;Behavior;behavior change;Behavior Therapy;Behavioral;behavioral economics;Businesses;Characteristics;Clinic;Cognitive;cognitive function;Communicable Diseases;community setting;Connecticut;Contracts;cost effective;cost effectiveness;Cost Effectiveness Analysis;cost estimate;Criminal Justice;Cultural Diversity;depressive symptoms;Development;Disability Evaluation;Disease Progression;disenfranchised population;Disparity;Drug usage;Drug Use Disorder;dual diagnosis;efficacious intervention;efficacy evaluation;Emotional;Emotional Stress;Employment;enhanced care;Evaluation;experience;Face;follow-up;Goals;Health;health disparity populations;Healthcare;HIV;HIV/AIDS;improved;improved outcome;indexing;Individual;Intervention;Job Application;Lead;Life Expectancy;Link;marginalized population;Mediator;Medical;medication compliance;meetings;Mental Depression;Methods;Monitor;Morbidity - disease rate;mortality;novel;Occupations;Outcome;Participant;Patients;Persons;physical conditioning;Physical Function;Positioning Attribute;Prize;Procedures;Productivity;Program Sustainability;programs;psychologic;psychological outcomes;Psychological reinforcement;psychological symptom;psychosocial;Quality of life;Randomized;randomized, clinical trials;Readiness;recruit;reinforcer;Rewards;Risk Behaviors;Risk Reduction Behavior;Searching Behavior;secondary outcome;Secure;service organization;Services;standard care;Structure;substance use;System;Time;Training;Unemployment;United States Social Security Administration;Veterans;Viral Load result;volunteer;welfare;Well in self;Work

PROJECT_TITLE: Promoting employment in persons living with HIV/AIDS

STUDY_SECTION: BSCH

STUDY_SECTION_NAME: Behavioral and Social Consequences of HIV/AIDS Study Section[BSCH]


PHR: PROJECT NARRATIVE: Analytical Core The Analytical Core (AC) provides analytical services to the Iowa Superfund Research Program to facilitate high-quality research on polychlorinated biphenyls (PCBs). The AC provides instrumentation and facilities, quality assurance standards and protocols, expert staff, training, data sharing platforms, and support for method development.

PROJECT_TERMS: Agreement;air sampling;animal tissue;Archives;Carcinogens;Collaborations;Complex;Core Facility;Data;Data Analyses;data integration;data management;data sharing;Databases;Detection;Development;Environment;experience;Faculty;FAIR principles;Food;Food Analysis;Foundations;Frequencies;graduate student;Health Hazards;high throughput analysis;Human;Hydroxylation;Infrastructure;innovation;instrument;instrumentation;Iowa;Laboratories;Laboratory Animals;Learning Module;Measurement;Metabolic;method development;Methods;microbial;Modeling;Neurologic;Paint;Peer Review;Pigments;Plant Resins;Plants;Polychlorinated Biphenyls;Polymers;polyurethane foam;Postdoctoral Fellow;Procedures;programs;Protocols documentation;Publications;quality assurance;Quality Control;Quartz;Recovery;Reference Standards;remediation;Reproducibility;Research;Research Personnel;Research Support;Risk;Sampling;Serum;Services;sharing platform;Signal Recognition Particle;Soil;Source;Standardization;statistics;Superfund;superfund chemical;Supervision;Technology;Testing;Tissues;Toxic effect;Training;Update;Water;water sampling

PROJECT_TITLE: Research Support Core: Analytical Core


NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Interstitial Cystitis;Multiple Sclerosis;Neurodegenerative;Neurosciences;Urologic Diseases

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Despite the crucial role of the brain in bladder control and its vulnerability to neurological disorders such as in multiple sclerosis (MS), there are no treatment options that modulate brain regions involved in proper bladder function. Addressing neurogenic overactive bladder (NOAB) is of high priority due to its prevalence as well as the morbid and costly manifestations of urinary frequency, urgency, and incontinence, along with the modest effectiveness and common adverse effects associated with current NOAB managements. This project investigates the therapeutic effects of individualized, noninvasive brain stimulation for the intractable condition of NOAB in MS, shifting bladder dysfunction management from a bladder-centric paradigm to brain restoration.

PI_NAMEs: KHAVARI, ROSE  (contact)

PROGRAM_OFFICER_NAME: REYNOLDS, WILLIAM STUART

PROJECT_TERMS: active method;Address;Adverse effects;Aftercare;Bladder;Bladder Control;Bladder Dysfunction;Brain;Brain region;Clinical;clinical center;Clinical Data;clinical effect;Clinical Trials;Controlled Clinical Trials;cost;Data;design;Development;Double-Blind Method;effective therapy;Effectiveness;Electromagnetic Fields;follow-up;Frequencies;Functional disorder;gray matter;Health;improved;Incontinence;incontinence symptom;Increased frequency of micturition;Individual;interest;Knowledge;Location;Lower urinary tract;Magnetic Resonance;Maintenance;Modality;Multiple Sclerosis;Multiple Sclerosis Lesions;National Institute of Diabetes and Digestive and Kidney Diseases;Nervous System Disorder;neural;neuroimaging;Neuronal Plasticity;Neuronavigation;Neurons;neuroregulation;noninvasive brain stimulation;novel;open label;Outcome;Overactive Bladder;Participant;Patients;Pattern;Phase;Phenotype;pilot trial;placebo group;Prediction of Response to Therapy;Prevalence;Quality of life;Randomized;repetitive transcranial magnetic stimulation;Research;Residual state;responders and non-responders;response;Rest;restoration;Role;Safety;symptomatic improvement;Symptoms;Testing;Therapeutic Effect;therapeutic target;Time;Transcranial magnetic stimulation;treatment group;urinary;urologic;white matter;Woman

PROJECT_TITLE: A randomized, sham-controlled clinical trial evaluating individualized neuromodulation of cortical regions involved in neurogenic overactive bladder in Multiple Sclerosis

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]