NIH_SPENDING_CATS: Cancer

PROJECT_TERMS: Adhesions;Adipocytes;Affect;Area;Basic Science;Biochemical;Blood Vessels;Cancer Biology;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Patient;Cancer Survivor;cancer therapy;Cell Communication;Cell Proliferation;Cells;Clinic;Clinical Trials;Collaborations;Communication;comorbidity;Complex;cytokine;Dedications;design;Development;Disease;Engineering;Epigenetic Process;Epithelial Cells;Extracellular Matrix;Fibroblasts;fighting;Focus Groups;Fostering;Functional disorder;functional genomics;Funding;Funding Agency;Future;Genetic;Goals;Grant;Growth Factor;Immune;improved;Individual;innovation;intercellular communication;Journals;Malignant Neoplasms;Maps;member;Metabolic;Metabolism;metabolomics;Modality;Molecular;mortality;Motility;multidisciplinary;Mutation;NCI Center for Cancer Research;Neoplasm Metastasis;neoplastic cell;novel therapeutic intervention;novel therapeutics;Paper;Pathway interactions;Patient Care;Patients;Peer Review;Pharmaceutical Preparations;Physicians;Play;Positioning Attribute;Process;programs;Publications;Publishing;Quality of life;quality of life for cancer survivors;Research;research and development;Research Personnel;Resistance;Schools;Scientist;Signal Pathway;Stromal Cells;Stromal Neoplasm;Structural Protein;Structure;success;Therapeutic;therapeutic target;therapy development;Tissues;Translating;translational scientist;Translations;tumor microenvironment;tumor progression;tumorigenesis;working group

PROJECT_TITLE: 10 Mechanisms of Cancer Biology Program


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Breast Cancer;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Orphan Drug;Rare Diseases;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PI_NAMEs: EBERLEIN, TIMOTHY J (contact)

PROJECT_TERMS: Address;Area;Atlases;Award;Bioinformatics;Brain Neoplasms;Breast;burden of illness;Cancer Biology;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Patient;Cancer Research Project;cancer risk;cancer site;cancer survival;cancer therapy;cancer type;Cellular biology;Chemoresistance;chemotherapy;Chest;Clinical;clinical application;Clinical Research;Clinical Trials;Clinical Trials Design;Clinical Trials Network;Collaborations;Colonic Neoplasms;Colorectal;Data;Defect;design;Development;Developmental Therapeutics Program;Direct Costs;Disease;Disparate;DNA Repair;DNA Sequence Alteration;drug discovery;early phase clinical trial;Education;Educational Activities;Elements;Endometrial;Enrollment;epigenomics;Evolution;first-in-human;Focus Groups;Funding;gastrointestinal;Genetic;Genitourinary system;Genome;Genomics;Germ Lines;Germ-Line Mutation;Glioblastoma;Goals;Group Meetings;Gynecologic Oncology;Head and Neck Cancer;Head and neck structure;Human;Immune;Immunotherapy;Impact evaluation;improved;inhibitor;innovation;Innovative Therapy;Institution;Intervention;Intervention Trial;ketogenic diet;Kidney;Knowledge;knowledge base;Leadership;Link;Lung;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mammary Neoplasms;Maps;Mediating;Medical Oncology;medical schools;meetings;member;Mentored Clinical Scientist Development Program;Mentorship;metabolomics;Methods;Mismatch Repair Deficiency;Modeling;Molecular;Molecular Abnormality;Neoplasm Metastasis;new therapeutic target;novel;novel strategies;novel therapeutics;Oncology;Ovarian;Pancreatic Adenocarcinoma;Paper;Patient Selection;Patient-Focused Outcomes;Patients;Peer Review;Pharmaceutical Preparations;Phase;Positioning Attribute;Pre-Clinical Model;Predisposition;programs;prospective;Prostatic Neoplasms;Proteomics;Publications;Publishing;Quality of life;Research;Research Personnel;Resistance;Resource Sharing;Resources;response;Role;sex;Sex Differences;Sex Differentiation;Site;Solid Neoplasm;spatiotemporal;Specialist;Specimen;success;synergism;targeted treatment;Technology;The Cancer Genome Atlas;Therapeutic;therapy outcome;therapy resistant;Training;Translating;Translational Research;treatment trial;trial enrollment;tumor;tumor immunology;tumor initiation;Universities;UV-induced Melanoma;Washington;Work;working group

PROJECT_TITLE: 11 Solid Tumor Therapeutics Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Acceleration;Address;African American;Annual Reports;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer health disparity;Cancer Patient;Cancer Survivor;Catchment Area;Clinical;clinical practice;Clinical Research;Clinical Services;Clinical Trials;Colorectal Cancer;Communities;community advisory board;community building;community collaboration;community engagement;community organizations;Community Outreach;community partnership;community research;Comprehensive Cancer Center;County;Data;demographics;Development;Diagnosis;Disparity;Education;Education and Outreach;Educational Materials;Ensure;Evaluation;Exhibits;falls;Foundations;Geography;Goals;Health Disparities Research;Health Services Accessibility;Health Status;Illinois;Incidence;Infrastructure;Insurance Coverage;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Medically Underserved Area;Minority;Minority Groups;Missouri;Monitor;mortality;NCI Center for Cancer Research;Outcome Assessment;outreach;patient oriented;Patients;Population;programs;Provider;Race;racial disparity;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;Research Support;research to practice;Research Training;Resources;response;Role;Rural;rural area;Rural Population;Science;Scientific Advances and Accomplishments;Solid;System;Translational Research;Translations;Underserved Population;Urban Population;Work;working group

PROJECT_TITLE: Community Outreach and Engagement


NIH_SPENDING_CATS: Cancer;Clinical Research

PROJECT_TERMS: Advanced Malignant Neoplasm;Award;Basic Science;Cancer Burden;Cancer Center;Cancer Center Support Grant;career;Catchment Area;clinical practice;Clinical Sciences;Clinical Trials;Collaborations;Communities;cost;Critiques;design;Development;Direct Costs;Faculty;Faculty Recruitment;Fostering;Foundations;Funding;Funding Mechanisms;Funding Opportunities;Future;Genomics;Grant;Image;Immunology;improved;Incentives;Infrastructure;innovation;Investments;Leadership;Malignant Neoplasms;meetings;member;Mentors;Modeling;Monitor;multidisciplinary;NCI Center for Cancer Research;novel;novel strategies;Outcome;Output;Peer Review;Peer Review Grants;Policies;Population Sciences;Prevention;Process;Productivity;programs;Publications;recruit;Recurrence;Research;research and development;Research Personnel;Research Support;Science;Strategic Planning;success;tool;United States National Institutes of Health;Vision

PROJECT_TITLE: Developmental Funds


PROJECT_TERMS: Advisory Committees;Annual Reports;anti-cancer research;authority;Award;Cancer Center;Cancer Center Support Grant;cancer research center director;Catchment Area;Clinical Cancer Center;Clinical Research;Clinical Trials;Collaborations;Committee Membership;Communication;community advisory board;community engagement;Community Outreach;Consensus;Decision Making;Discipline;Eligibility Determination;Evaluation;Family;Feedback;follower of religion Jewish;Fostering;Funding;Future;Healthcare;Hospitals;improved;Institution;Investments;Joints;Leadership;medical schools;meetings;member;Mission;operation;Parents;Patients;Peer Review;Performance;Play;Policies;Productivity;programs;Recommendation;Reporting;Research;research and development;Resource Sharing;Review Committee;Role;Shapes;Strategic Planning;Structure;synergism;Training and Education;Translational Research;Universities;Update;Vision;Washington;Work;working group

PROJECT_TITLE: Leadership, Planning and Evaluation


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety

PROJECT_TERMS: anti-cancer research;Area;Cancer Center;Cancer Center Support Grant;Catchment Area;Childhood;Clinical Data;Clinical Protocols;Clinical Research;Clinical Treatment;clinical trial readiness;Clinical Trials;Data;Data Collection;data management;Development;Education;electronic data capture system;empowerment;Ensure;experience;Growth;Industry;Information Systems;Infrastructure;innovation;Institution;Institutional Review Boards;Intervention;Intervention Trial;investigator-initiated trial;medically underserved;member;Minority;minority patient;Mission;Monitor;Monitoring Clinical Trials;Occupational activity of managing finances;online repository;Participant;patient population;Patients;Performance;Population;process improvement;protocol development;Protocols documentation;quality assurance;real time monitoring;recruit;Reporting;Research;Research Personnel;Review Committee;rural underserved;Services;System;Technology;Time;timeline;Training

PROJECT_TITLE: Clinical Protocol and Data Management


PROJECT_TERMS: anti-cancer research;authority;Automation;behavioral outcome;Behavioral Sciences;Biometry;Bone Marrow Transplantation;Cancer Center;Cancer Center Support Grant;cancer diagnosis;Clinical Trials;Committee Members;design;Discipline;Ensure;expectation;Focus Groups;Goals;Guidelines;Gynecologic Oncology;Health;Health Sciences;human subject;improved;Industrialization;Industry;Institution;Institutional Review Boards;Intervention;Leadership;Malignant Neoplasms;Medical Oncology;meetings;Monitor;NCI-Designated Cancer Center;Participant;Pathology;Patients;Pediatric Oncology;Peer Review;Performance;Persons;Pharmacy facility;Placebos;Population;Process;prospective;protocol development;Protocols documentation;Psychology;Public Health;Radiation Oncology;Radiology Specialty;Reporting;Research;Research Design;Research Personnel;research study;Review Committee;Risk;sound;Source;Standardization;Surgical Oncology;System;timeline;Toxic effect;United States National Institutes of Health;University resources;Work

PROJECT_TITLE: Protocol Review and Monitoring System


ADMINISTERING_IC: AI

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vector-Borne Diseases

ORG_CITY: BLACKSBURG

ORG_DEPT: ZOOLOGY

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Narrative Cache Valley virus (CVV) is an important, zoonotic, arthropod-borne virus in North America that can potentially emerge and become a major pathogen of humans, wildlife and livestock. CVV emergence can result in potentially devastating consequences on our economy, food availability, human and animal health. To circumvent this threat, we will develop a lipid inorganic nanoparticle formulated, replicon-RNA vaccine that demonstrates exceptional immunogenicity and outstanding safety, and completely protects against all aspects of CVV disease, including viral-induced abortions and congenital birth defects.

PI_NAMEs: AUGUSTE, ALBERT J. (contact);ERASMUS, JESSE HONG-SAE

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Adoption;Advisory Committees;Agriculture;Animal Diseases;Animals;Antibodies;Antigens;Arboviruses;arthropod-borne;Brazil;Bunyavirales;burden of illness;Cache Valley virus;Case Study;Categories;Cessation of life;Characteristics;Chikungunya virus;Chronic;Clinical;clinical development;Clinical Trials;Collaborations;combat;Congenital Abnormality;Coupled;Coupling;COVID-19 pandemic;cross reactivity;Culicidae;Disease;dosage;Dose;Economic Burden;Economics;Emergency Situation;emerging virus;Encephalitis;enzootic;Epidemic;epidemic potential;epizootic;Event;Fatigue;Fever;Food;Future;future epidemic;Genus Phlebovirus;Geographic Distribution;Geography;Goals;Headache;Health;Health protection;High Prevalence;Human;human pathogen;Immune response;Immunity;Immunization;Immunocompetent;immunogenic;immunogenicity;Immunologist;In Vitro;in vivo;Incidence;India;Induced Abortion;Infant;Infection;innovation;Licensing;Lipids;Livestock;Longevity;Macrocephaly;Maps;Marketing;Medical;member;Meningitis;Morbidity - disease rate;mortality;mouse model;Musculoskeletal System;nanoparticle;National Institute of Allergy and Infectious Disease;Nausea;Neurologic;North America;novel;Orthobunyavirus;pathogen;Pathogenesis;Phenotype;Positioning Attribute;preclinical development;preclinical evaluation;Prevalence;prevent;Prevention;protective efficacy;prototype;Recording of previous events;Regimen;Replicon;Reporting;Resources;response;Rift Valley fever virus;Risk;RNA;RNA vaccine;RNA Viruses;Role;Ruminants;Safety;safety study;Seroprevalences;South Korea;Spontaneous abortion;Study models;System;T cell response;Technology;Teratogens;Testing;transmission process;United States National Institutes of Health;Vaccination;vaccine candidate;vaccine development;vaccine efficacy;vaccine platform;vaccine trial;Vaccines;vaccinology;vector;Venezuelan Equine Encephalitis Virus;Viral;Viral Antigens;Viral Pathogenesis;Virus;Virus Diseases;Virus Replication;Zika Virus;Zoonoses

PROJECT_TITLE: Pre-clinical evaluation of alpha-Cache; a novel RNA vaccine for an emerging orthobunyavirus

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE A range of neuropsychiatric disorders, including obsessive-compulsive disorder (OCD) and addiction, are theorized to involve maladaptive habit formation, contributing to compulsions and disruptive repetitive behavior. Current approaches to treating these disorders are limited because we lack a solid foundation for understanding the basic neurobiological processes that go awry to produce symptoms. This project focuses on answering fundamental questions about the neural circuit mechanisms underlying habit formation and motor skill acquisition with the ultimate goal of deciphering how dysfunction in these circuits contributes to OCD, addiction, and other neuropsychiatric disorders.

PI_NAMEs: LERNER, TALIA NEWCOMBE (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: addiction;Address;adverse outcome;Anatomy;Area;Automation;Behavior;Behavioral;behavioral response;behavioral study;Brain;Brain region;candidate identification;cell type;Cells;Complex;compulsion;Corpus striatum structure;cost;Data;Dendrites;Dependence;Disease;Disinhibition;Distal;Dopamine;dopaminergic neuron;Electrophysiology (science);Environmental Risk Factor;Excitatory Synapse;experimental study;Fiber;field study;flexibility;Formulation;Foundations;Functional disorder;Future;Genetic;Goals;Habits;in vivo;Individual;Influentials;innovation;Laboratories;Learning;Lighting;Liquid substance;Location;Long-Term Potentiation;maladaptive behavior;Maps;Measures;Mental disorders;Midbrain structure;Modeling;Monkeys;motivated behavior;Motor Skills;Mus;neural circuit;Neurobiology;neuromechanism;Neurons;neuropsychiatric disorder;Neurosciences;Obsessive-Compulsive Disorder;optogenetics;Outcome;Pacemakers;Pattern;Photometry;Positioning Attribute;Process;Property;recruit;Regulation;repetitive behavior;Research;Research Personnel;Response to stimulus physiology;Rest;Rewards;Role;skill acquisition;skills training;Slice;Solid;Source;Substantia nigra structure;Symptoms;Synapses;Synaptic plasticity;Technical Expertise;Technology;Testing;theories;Time;Training;Work

PROJECT_TITLE: Plasticity and Function of Dopamine Circuits Regulating the Transition to Habit

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Prevention

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: PROJECT NARRATIVE The current proposal reexamines protein turnover as a mechanism to maintain proteostasis with age. We use novel mouse models, isotopic labeling, treatments that slow aging and advanced mass spectroscopy to understand the conflicting data related to protein turnover and aging and to understand mechanisms to maintain proteostasis. The successful completion of this study will overcome a significant hurdle in the understanding of proteostasis to appropriately target proteostatic mechanisms to slow aging.

PI_NAMEs: MILLER, BENJAMIN FRANCIS (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Adult;Age;age related;age related decline;age-related disease;aged;Aging;Astrocytes;Brain;Cell Nucleus;Cell Proliferation;cell type;Cells;Confusion;Consensus;Data;Deterioration;Deuterium Oxide;DNA;Elderly;Estradiol;extend lifespan;Goals;hallmarks of aging;Heterogeneity;improved;in vivo;Individual;Isotope Labeling;Isotopes;Label;Maintenance;Mass Spectrum Analysis;Measurement;Methodology;Methods;mouse model;mTOR inhibition;Mus;Muscle Cells;Muscle satellite cell;Neurons;novel;novel strategies;Pathway interactions;postmitotic;Predisposition;prevent;Protein Biosynthesis;protein degradation;Protein Dynamics;Proteins;Proteomics;proteostasis;proteostasis loss;Quality Control;Research;Sirolimus;Skeletal Muscle;stable isotope;Testing;Therapeutic;Time;Tissue Sample;Tissues

PROJECT_TITLE: Dissecting the integrated mechanisms of protein turnover to prevent proteostatic decline with aging

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative Religious practice often predicts opposition to genomic and genetic healthcare. We will explore why: Does it have to do with personal practices, beliefs, or characteristics of faith communities? We will also interview faith leaders to learn how public health genetic professionals might engage faith communities respectfully and constructively.

PI_NAMEs: DUBOIS, JAMES M (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, DAVE J

PROJECT_TERMS: Address;Adoption;Adult;Attitude;Belief;Bible;Black Populations;Black race;Cessation of life;Characteristics;Christianity;Communities;COVID-19 vaccine;Data;Education;Educational Status;Ensure;ethical, legal, and social implication;experience;Faith;Faith leader;follower of religion Jewish;Frequencies;Genes;Genetic;genetic testing;Genomics;health disparity;Health Technology;Healthcare;Healthcare Activity;Healthcare Systems;Hispanic Populations;Human;innovation;instrument;interest;Interview;Knowledge;Learning;Life;Measurement;Messenger RNA;Modeling;Morals;Muslim population group;Muslim religion;National Human Genome Research Institute;new technology;Participant;Persons;Play;Population;Prayers;prenatal;Protestant;Public Health;Qualitative Research;Regression Analysis;Religion;religious group;Research;Research Methodology;Research Personnel;response;Risk;RNA vaccine;Role;Rural Population;Sample Size;Sampling;Scientist;Services;Shapes;stakeholder perspectives;stem;stem cell therapy;Subgroup;Surveys;Technology

PROJECT_TITLE: Religion and support for genomic healthcare: An exploratory study of the US public and faith leaders.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-SEIR-E(80)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Infectious Diseases;Networking and Information Technology R&D (NITRD);Pediatric;Rare Diseases;Vector-Borne Diseases

ORG_CITY: Nashville

ORG_DEPT: CHEMISTRY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE  Schistosomiasis is endemic in 54 countries and 700 million people are at risk of infection. School-aged children are the most at-risk population, and infection is associated with long term morbidities. As disease control efforts transition to elimination, there is a pressing need for improved surveillance tools.

PI_NAMEs: SCHERR, THOMAS F (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Academic Medical Centers;Accounting;Acute;Address;Administrator;advanced analytics;Africa South of the Sahara;Algorithms;Anatomy;Anemia;antigen test;chemotherapy;Child;Chronic;cognitive development;Computer software;Country;dashboard;Data;Data Analyses;Data Collection;detection limit;Development;Devices;Diagnostic;diagnostic algorithm;Diagnostic Equipment;Diagnostic tests;Diarrhea;disorder control;empowerment;Environment;Evaluation;experience;Fatigue;Feedback;field study;flexibility;Focus Groups;Foundations;Friends;Funding;global health;Goals;Growth;Health;HIV;Human Subject Research;Hypertension;image processing;Impairment;improved;Infection;infection risk;Institutional Review Boards;International;Intervention;iterative design;Kenya;Knowledge;Laboratories;Libraries;life span;Link;Malaria Diagnosis;Malnutrition;Medical Research;member;mHealth;mobile application;mobile computing;Morbidity - disease rate;neglected tropical diseases;Online Systems;Pain;Performance;Persons;Pharmaceutical Preparations;point of care;point of care testing;point-of-care diagnostics;Populations at Risk;Praziquantel;Preparation;primary outcome;programs;Prophylactic treatment;Protocols documentation;Public Health;Recording of previous events;Research;Research Institute;Resolution;response;Risk;SARS-CoV-2 antibody;Schistosomiasis;School-Age Population;Sensitivity and Specificity;Site;software development;Speed;standard care;success;surveillance study;System;Testing;Time;tool;tool development;Universities;Update;usability;web app;web platform;World Health Organization

PROJECT_TITLE: MEDSCAN: Mobile Enabled Diagnostics for Schistosomiasis Control Analytics

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Aging;Bioengineering;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: WORCESTER

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: NARRATIVE The research proposed here will determine how the human genome is folded inside the cell nucleus, and how this organization changes as cells go through important transitions during early differentiation and during aging. The work will produce important reference maps for the organization of the human genome during these critical phases of life, as well as new tools to study and visualize the structure and dynamics of the genome. The results can provide mechanistic insights into how genomes are regulated and will lead to a deeper understanding of how altered chromosome conformation can contribute to a variety of human diseases including premature aging.

PI_NAMEs: DEKKER, JOB  (contact);MIRNY, LEONID A

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: 3-Dimensional;Address;Age;Aging;Algorithms;Benchmarking;Biological;Biological Assay;biophysical model;Biophysical Process;biophysical properties;Biophysics;cell age;Cell Cycle;Cell Differentiation process;Cell Nucleolus;Cell Nucleus;Cells;Chromatin;Chromatin Loop;chromosomal location;Chromosome Structures;Chromosomes;cohesin;Collaborations;Computer software;computerized data processing;Data;data format;data integration;Data Set;data standards;data visualization;Defect;Deposition;Deterioration;Development;developmental disease;Disease;embryonic stem cell;Engineering;epigenomics;experience;file format;Foundations;Gene Expression;Gene Expression Regulation;Genetic Transcription;Genome;Genome Mappings;Genome Stability;Genomics;Goals;Hand;Hepatocyte;Heterochromatin;Hi-C;Histones;human disease;Human Genome;Image;Imaging technology;insight;interest;Knowledge;Life;life span;Liquid substance;Maintenance;Malignant Neoplasms;Maps;Measures;Mediating;member;Memory;Methodology;Methods;Modeling;Molecular;Molecular Conformation;multiple data types;Nuclear;Organizational Change;Pathway interactions;Phase;Physics;Play;Polymers;Positioning Attribute;predictive modeling;premature;Premature aging syndrome;Process;Progeria;Property;Proteins;Proteome;Proteomics;Research;Resolution;RNA;Role;Sampling;segregation;Shapes;simulation;stem cell differentiation;Structure;Syndrome;technological innovation;Technology;Testing;three dimensional structure;tool;transcriptome;Variant;Visualization;Visualization software;Work

PROJECT_TITLE: Center for 3D Structure and Physics of the Genome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T(50)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: There is an etiologic synergy between Aβ deposition and tau misfolding in the pathogenesis of both early- and late-onset Alzheimer’s disease. In this project, we will investigate whether specific phosphorylation sites on tau protein are crucial in driving this synergy. We will also explore whether specific types of amyloid deposits are required for maturation of soluble tau into intracellular inclusions. Data generated in this proposal will broaden our mechanistic knowledge of the neuropathologic cascade in Alzheimer’s disease.

PI_NAMEs: BORCHELT, DAVID R;CHAKRABARTY, PARAMITA  (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: abeta deposition;Abeta synthesis;adeno-associated viral vector;Age;Age Months;Aging;Alanine;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Amyloid;Amyloid beta-Protein;Amyloid deposition;amyloid pathology;Amyloidosis;Antibodies;Aspartic Acid;Automobile Driving;beta amyloid pathology;Brain;Characteristics;Clinical;Cognitive deficits;Collection;Data;Data Analyses;Dementia;Deposition;design;Diffuse;Early Onset Familial Alzheimer's Disease;Elderly;Environment;Epitopes;Etiology;Event;Exhibits;extracellular;Goals;Harvest;Hippocampus;histological stains;Human;hyperphosphorylated tau;improved;Individual;Injections;insight;Knowledge;Laboratories;Late Onset Alzheimer Disease;Link;Maps;Mediating;mimetics;Modeling;mouse model;Mus;Mutate;Mutation;Nerve Degeneration;neurofibrillary tangle formation;Neurofibrillary Tangles;neuropathology;Newborn Infant;Outcome;Pathogenesis;Pathologic;Pathology;pharmacologic;phosphoproteomics;Phosphorylation;Phosphorylation Site;Process;Recombinant adeno-associated virus (rAAV);Research;Role;Secondary to;Senile Plaques;Severities;Site;Symptoms;synergism;tau aggregation;tau expression;tau interaction;tau mutation;tau Proteins;tau-1;Tauopathies;Technology;Tetracyclines;Transgenic Mice;Transgenic Model;Variant;Virus;Work;β-amyloid burden

PROJECT_TITLE: Deciphering tau phosphorylation and Abeta/tau strain interactions in Alzheimer’s pathogenesis

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Genetics;Lung;Prevention;Rare Diseases

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: The Acute Respiratory Distress Syndrome (ARDS) is a global public health concerns that is currently managed by life support measures in intensive care unit across the USA. Although survival has improved with judicial fluid management and protective ventilation strategies, there are no specific pharmacologic treatments that are based on the molecular pathogenesis. The main objective of this research is to define the molecular mechanisms that regulate the role of macrophages in ALI/ARDS development and show that pharmacologic interdiction can be developed as a novel approach to prevention and treatment of ARDS that will improve human health outcomes from critical illness.

PI_NAMEs: CHRISTMAN, JOHN W (contact);KARPURAPU, MANJULA

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: Ablation;absorption;Acute Respiratory Distress Syndrome;Address;Affect;Alveolar;alveolar epithelium;Alveolar Macrophages;Amino Acids;Arachidonic Acids;Bacteremia;Berlin;Blood capillaries;Calcineurin;Calcineurin inhibitor;Capillary Permeability;cecal ligation puncture;Cell Communication;Cell model;cell type;Cells;cellular targeting;clinically relevant;Complication;COVID-19;Critical Illness;current pandemic;cytokine;cytokine release syndrome;Data;Death Rate;Development;Disease;efficacy evaluation;efficacy testing;Endocytosis;Enzymes;Epithelial Cells;Escherichia coli;extracellular vesicles;Functional disorder;Genetic;Goals;Health;Human;improved;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;Injury;Intensive Care Units;Interleukin-6;Intravenous;Knowledge;Lead;Life;lipid mediator;lipid metabolism;Lipids;Lipopolysaccharides;Liquid substance;Lung;lung injury;Lung Lavage Fluid;lung microvascular endothelial cells;Macrophage;Measures;Mediating;Mediator;meetings;Metabolism;Modeling;Molecular;Molecular Target;mouse model;Mus;neutrophil;new therapeutic target;novel;novel strategies;nuclear factors of activated T-cells;Outcome;Pathogenesis;Pathway interactions;Patients;Peptides;Permeability;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacological Treatment;Phenotype;pre-clinical;prevent;Prevention approach;Property;Proteins;Proteolysis;PTGS2 gene;Public Health;Publishing;Pulmonary Edema;Pulmonary Inflammation;Regulation;Research;Resistance;Resolution;Role;Route;Safety;Severity of illness;Staphylococcus aureus;Structure;Supportive care;T-Cell Activation;Testing;TNF gene;transcription factor NF-AT c3;Transcriptional Activation;treatment response;Vascular Endothelium;ventilation;Ventilator-induced lung injury;Work

PROJECT_TITLE: REGULATION OF THE MACROPHAGE INFLAMMATORY PHENOTYPE IN ARDS

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Physical Activity;Prevention

ORG_CITY: PHILADELPHIA

ORG_DEPT: NUTRITION

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: Narrative Individuals with overweight/obesity can improve their health with weight loss, but maintaining long-term changes in eating behavior and physical activity is difficult. This study is designed to test new approaches to supporting long-term behavior change. Specifically, this study will test whether using coaches, program peers, or family/friends as sources of support and accountability can improve long-term weight loss.

PI_NAMEs: BUTRYN, MEGHAN  (contact)

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: Accountability;Address;Adult;automated text message;Behavior;behavior change;Behavioral;Body Weight;Body Weight decreased;Body Weights and Measures;Calories;Data;data sharing;design;Devices;Diet Records;Dietary intake;digital;digital data;digital technology;digital tool;Eating;Eating Behavior;Enrollment;experience;Family;Family member;Friends;Goals;Group Meetings;Health;improved;indexing;Individual;Informal Social Control;Intake;Intervention;intervention effect;Judgment;Life Style Modification;Maintenance;Measures;Mediator;member;Monitor;Motivation;novel strategies;Obesity;Outcome;Overweight;Participant;peer;Performance;Physical activity;Prediction of Response to Therapy;primary outcome;programs;Randomized;randomized trial;secondary outcome;sensor;smartphone application;social;Social support;Source;Telephone;Testing;Text Messaging;Time;tool;Training;treatment effect;Treatment Efficacy;videoconference;Videoconferencing;wearable device;wearable sensor technology;Weight;wireless

PROJECT_TITLE: Sharing Digital Self-Monitoring Data with Others to Enhance Long-Term Weight Loss: A Randomized Trial using a Factorial Design

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Data Science;HIV/AIDS;Infectious Diseases;Networking and Information Technology R&D (NITRD)

ORG_CITY: DURHAM

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative An interdisciplinary team approach is necessary to fully address current HIV/AIDS research challenges that generate massive amounts of complex, high-dimensional data. Such teams need cross-trained biomedical and quantitative scientists who can communicate effectively and collaborate productively. This research education program is designed to train the future HIV/AIDS workforce to conduct rigorous data-driven research that follows open science principles — through workshops, internships, and mentoring programs that build domain knowledge, quantitative skills, and team science experiences.

PI_NAMEs: CHAN, CLIBURN C (contact);POMANN, GINA-MARIA

PROGRAM_OFFICER_NAME: MOTEN, CARMEN

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Area;Basic Science;Behavioral Sciences;Big Data;Bioinformatics;bioinformatics pipeline;Biological;Biological Assay;career;career development;Case Study;Clinical;Clinical Sciences;Collaborations;Communication;Communities;Competence;Complex;computer science;computer scientist;Consult;Consultations;Country;Data;Data Analyses;data complexity;Data Science;Dedications;design;Development;Discipline;doctoral student;education research;Educational process of instructing;Educational workshop;Engineering;Ensure;Environment;experience;Faculty;Feedback;First Generation College Students;Foundational Skills;Future;Goals;graduate student;Grant;high dimensionality;HIV;HIV vaccine;HIV/AIDS;implementation science;Institution;Interdisciplinary Study;interest;Internships;Knowledge;Language;Learning Skill;machine learning prediction;mathematical sciences;Mentors;Mentorship;Methodology;Methods;multidimensional data;multidisciplinary;North Carolina;novel;open data;Participant;peer;Pilot Projects;Postdoctoral Fellow;predictive modeling;Productivity;programs;Recording of previous events;Reproducibility;Research;Research Personnel;Research Project Grants;Resource Development;Resources;Scholars Program;Science;Scientist;Series;skills;Social Behavior;statistics;Structure;summer internship;support network;Talents;Testing;Training;Training and Education;training opportunity;Training Programs;Translational Research;Underrepresented Minority;vaccine development;Visualization;Work

PROJECT_TITLE: Quantitative Methods for HIV/AIDS Research


ADMINISTERING_IC: GM

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Auburn

ORG_NAME: AUBURN UNIVERSITY AT AUBURN

ORG_STATE: AL

PHR: Project Narrative Environmental health is an important component of public health programs, with developmental processes such as reproduction, particularly vulnerable. Through its impact on reproductive health, the environment generates novel genetic variation that can lead to reproductive incompatibilities, which can ultimately cause infertility between individuals that have been differentially exposed. This proposal will study how the environment impacts oogenesis to produce genetic incompatibilities.

PI_NAMEs: STEVISON, LAURIE SHERIE (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Area;Biodiversity;biological adaptation to stress;Biology;Chromatin;Coupled;Data;Developmental Process;DNA Repair;DNA Transposable Elements;Drosophila genus;Environment;Environmental Health;fitness;Gametogenesis;Gene Expression;Gene Expression Regulation;Genetic;Genetic Drift;Genetic Recombination;genetic variant;Genetic Variation;Hybrids;Individual;Infertility;Infertility study;innovation;Investigation;Link;male;Measures;Meiotic Recombination;Molecular Conformation;Molecular Target;mutant;novel;Nucleotides;Oogenesis;Outcome;Pathway interactions;Phenotype;Planet Earth;Process;programs;Public Health;Recurrence;Reproduction;reproductive;Reproductive Health;Research;Robot;Role;Source;Spontaneous abortion;Stress;stressor;Transcriptional Silencer Elements;Variant;Work

PROJECT_TITLE: The Role of Oogenesis in Speciation

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: HOUSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE This project is to study the structure and function of a membrane phosphatase protein PgpA essential for metabolic regulation in bacterium. We will demonstrate how PgpA regulates its catalytic activity by altering its protein conformation to control the bacterial cellular metabolism in the bacterial inner membrane. Performing this study may lead to new therapeutic strategies dealing with bacterial infectious diseases and antibiotic resistance.

PI_NAMEs: ZHENG, LEI  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Active Sites;aminoacid biosynthesis;Anabolism;Antibiotic Resistance;antimicrobial;Bacteria;Bacterial Infections;bacterial metabolism;Binding;Binding Sites;Biochemical;Biochemistry;Biological Assay;blood glucose regulation;Calorimetry;Carbon;Catalysis;cell growth;Cell membrane;Cell Survival;cell type;Chemicals;Chemistry;cofactor;Communicable Diseases;Computer Models;crosslink;Cryoelectron Microscopy;Crystallization;Cysteine;Cytoplasm;Data;Development;Diffusion;dimer;Disease Resistance;Disulfides;Environment;Enzymes;Equilibrium;Escherichia coli;Eukaryota;Family;Fermentation;Fluorescence;Fluorescence Resonance Energy Transfer;Gene Expression;genetic approach;Genetic Transcription;Glucose;Glucose Transporter;glucose uptake;Glutathione;Glutathione Disulfide;Glycolysis;Gram-Negative Bacteria;Growth;Homeostasis;Homologous Protein;In Situ;In Vitro;inorganic phosphate;insight;Integral Membrane Protein;Intracellular Membranes;Label;Lipid Bilayers;Lipids;Measures;Mediating;Membrane;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methods;Microbiology;microorganism;Molecular;Molecular Conformation;Monitor;mutant;Mutation;nanodisk;novel;novel therapeutic intervention;Oxidation-Reduction;Pacemakers;particle;pathogen;Pathway interactions;Phosphatidylglycerols;Phospholipids;Phosphoric Monoester Hydrolases;prevent;Prokaryotic Cells;Protein Conformation;Protein phosphatase;Proteins;Regulation;Reporting;Resolution;response;Roentgen Rays;Role;Signal Transduction;Site;Structure;Surface;Testing;Titrations;unnatural amino acids;vapor;Virulence;X-Ray Crystallography

PROJECT_TITLE: Structure and function of a metabolic pacemaker in bacterial cell membrane

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Burden of Illness;Caregiving Research;Clinical Research;Palliative Care

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative A broad population now has access to Medical Aid in Dying (MAiD), yet knowledge of the epidemiologic, experiential, and decision-making characteristics of individuals considering and pursuing MAiD are lacking and may be critical to inform evidence-based policies and practices. Furthermore, understanding the perspectives of family members/caregivers and clinicians caring for MAiD patients will help inform support that may be needed after these experiences.

PI_NAMEs: FISCHER, STACY M (contact);MATLOCK, DANIEL D

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Academy;Address;Adopted;Advocate;Affect;Aging;American;American Medical Association;Assisted Suicide;Attitude;Bioethics;California;Caregivers;Caring;Cause of Death;Characteristics;cohort;Collaborations;Colorado;Communities;Complex;Congresses;Counseling;Data;Death Certificates;Death with Dignity;Decision Making;District of Columbia;Dose;Emotional;end of life;end of life care;Epidemiology;Equity;Ethics;Euthanasia;evidence base;experience;Face;Family;Family Caregiver;Family member;functional decline;Funding;Goals;Hawaii;Health;hospice environment;Hospitals;Human;Human Characteristics;Individual;innovation;Intention;Intervention;Justice;Knowledge;Laws;Legal;Life;Literature;Longitudinal cohort;Longitudinal cohort study;Maine;Medical;multidisciplinary;Neurology;New Jersey;New Mexico;older adult;Oregon;Outcome;Palliative Care;Participant;Patient Care;Patients;Persons;Pharmaceutical Preparations;Physician's Role;Physicians;Policies;Population;Positioning Attribute;Privacy;Process;Professional Organizations;Prognosis;Provider;public health insurance;Religion;Religious Belief;Research;Research Personnel;Research Project Grants;Resuscitation;Sampling;Services;Statutes and Laws;Suicide;Surveys;Time;United States National Institutes of Health;Vermont;Washington

PROJECT_TITLE: Decision trajectories of patients at the end of life: An epidemiological exploration of MAID and the impact on caregivers and clinicians

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-V(02)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE Young Black men who have sex with men (YBMSM) have a high incidence of HIV in the South and interventions to enhance engagement in prevention services are urgently needed. Barriers to PrEP uptake among YBMSM occur at each level of modified social ecological model (MSEM) and include access, cost, transportation, low perceived HIV risk, stigma, and medical mistrust. Utilizing components of Acceptance and Commitment Therapy, we will design an intervention to improve PrEP uptake, persistence, and adherence through addressing these barriers.

PI_NAMEs: ARNOLD, TRISHA  (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;AIDS prevention;Anxiety;Award;Awareness;Behavior;behavior change;Behavioral;behavioral outcome;black men who have sex with men;brief intervention;care costs;career;Caring;Chronic;Client satisfaction;Clinic;Clinic Visits;Clinical;Communities;community barrier;Consent;cost;Coupled;Data;Data Analyses;design;Development;Education;Educational workshop;Eligibility Determination;Emotions;Epidemic;Esthesia;Evidence based intervention;experience;flexibility;Future;Health behavior;health disparity;HIV;HIV Infections;HIV risk;HIV/AIDS;Hospitals;implementation science;improved;Incidence;Individual;infection risk;innovation;Intervention;Interview;K-Series Research Career Programs;Literature;Measures;Mediator;Medical;Memory;Mentors;mindfulness;Modality;Modeling;Monitor;motivational enhancement therapy;Names;Outcome;Participant;Perception;Permeability;Pharmaceutical Preparations;Phase;Pilot Projects;Policies;Population;pre-exposure prophylaxis;Prevention;prevention service;primary outcome;Process;Promoting Action on Research Implementation in Health Services framework;Provider;psychologic;Psychologist;Public Policy;Publishing;Questionnaires;racial minority;Randomized;Randomized, Controlled Trials;Reproducibility;Research;Research Personnel;Research Priority;Research Project Grants;Respiration;Rhode Island;Risk;Running;Scientist;secondary outcome;Services;sexual minority;side effect;social;social stigma;Specific qualifier value;standard of care;success;Testing;theories;Therapeutic Intervention;therapy design;Thinking;Training;Transportation;United States National Institutes of Health;uptake;young adult

PROJECT_TITLE: An Acceptance Based PrEP Intervention to Engage Young Black MSM in the South

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Rare Diseases

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Post-translational modifications of histone tails play a central role in cellular identity and genome maintenance. The goal of this research is to establish the epigenetics and DNA repair mechanisms affected by the expression of a mutant histone 3 (H3K36M) in human cells, which may enable the design of novel therapeutic strategies for controlling genome stability.

PI_NAMEs: MOREY, LLUIS  (contact);VERDUN, RAMIRO ERNESTO

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Affect;antagonist;Biological Models;BRCA1 gene;Catalogs;Cell Death;Cell Proliferation;Cells;chemotherapy;Chromatin;clinically relevant;Complex;Cues;Data;Decitabine;Deposition;design;developmental disease;disease model;DNA;DNA Double Strand Break;DNA Methylation;DNA Repair;DNA Repair Inhibition;Double Strand Break Repair;Environment;Epigenetic Process;epigenome;Equilibrium;Excision;Functional disorder;Gene Expression Regulation;gene repression;Genes;Genetic Transcription;Genome;genome integrity;Genome Stability;genome-wide;Genomic Instability;Goals;Head and Neck Disorder;Head and Neck Squamous Cell Carcinoma;Histone Code;Histone H3;histone methylation;histone modification;Histones;Homeostasis;homologous recombination;homologous recombination deficiency;Human;In Vitro;in vivo;inhibitor;interest;Lead;Lysine;Maintenance;Malignant Childhood Neoplasm;Mediating;metaplastic cell transformation;Methionine;Methyltransferase;Molecular;mutant;Mutation;Nonhomologous DNA End Joining;novel;novel marker;novel therapeutic intervention;Outcome;p53-binding protein 1;Pathway interactions;Play;Polycomb;Post-Translational Protein Processing;PRC1 Protein;Process;programs;Proteins;recruit;Research;Role;Site;Structure;Tail;Testing;therapeutic target;Up-Regulation;Variant;Work

PROJECT_TITLE: Altering the chromostasis and genome stability by modulating histone methylation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-M(02)M]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence;Pediatric;Prevention;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: PEDIATRICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Multisystem inflammatory syndrome in children (MIS-C) is a disease caused by SARS-CoV-2 virus. Clinically it manifests 4-6 weeks after initial SARS-CoV-2 infection. The pathophysiological determinants are largely unknown, as is the ability to assess the relative risk of disease development, disease diagnosis and prognosis.

PI_NAMEs: BOGUNOVIC, DUSAN  (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: 2019-nCoV;Acute;Adult;Age;Algorithms;Antibody Repertoire;Area;Autoantibodies;Biological;Biological Assay;Biological Markers;biomarker identification;Blood;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;Child;Child Development;Childhood;Clinical;clinical center;cohort;comparison control;Computer Models;coronavirus disease;COVID-19;COVID-19 mortality;COVID-19 pandemic;Critical Care;Data;Data Collection;Data Set;Development;Diagnosis;Disease;disease diagnosis;Disease Outbreaks;disease prognosis;disorder risk;early childhood;exome sequencing;follow-up;Functional disorder;Genetic;Genomics;Immune;Immunologics;Immunophenotyping;improved;Individual;Infection;infection rate;Inflammation;Inflammatory;Influenza A virus;Influenza B Virus;Institutional Review Boards;Life;London;long-term sequelae;Machine Learning;machine learning algorithm;machine learning method;Maps;Measurement;Modeling;Mononuclear;Morbidity - disease rate;Mucocutaneous Lymph Node Syndrome;Multisystem Inflammatory Syndrome in Children;New York City;novel;Outcome;pathogen;Pathogenesis;Patients;pediatric patients;Phase;Pneumonia;post SARS-CoV-2 infection;Prognosis;Publishing;recruit;Relative Risks;Reporting;Respiratory Disease;Risk;Risk Assessment;risk prediction;risk stratification;risk variant;Sampling;SARS coronavirus;SARS-CoV-2 antibody;SARS-CoV-2 infection;SARS-CoV-2 positive;Serology;Shock;single-cell RNA sequencing;Site;Spain;Surface;Symptoms;Syndrome;Technology;Time;Virus;World Health Organization

PROJECT_TITLE: Immunologic and Predictive Features of MIS-C

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-B(90)]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: TORONTO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: HOSPITAL FOR SICK CHLDRN (TORONTO)

ORG_STATE: ON

ORG_ZIPCODE: M5G 1X8

PHR: Narrative The BioGRID database provides an extensive collection of protein and genetic interaction data for the major model organism species and humans, with user-oriented tools to explore this information. The BioGRID facilitates better understanding of human disease by enabling inference of gene and protein function through network context and the computational comparison of these gene and protein networks in human health and disease to analogous networks mapped in model organisms. The vast amounts of data in the BioGRID are freely provided to many other databases and biomedical researchers, thus enabling both fundamental and translational research.

PI_NAMEs: DOLINSKI, KARA ;TYERS, MIKE  (contact)

PROGRAM_OFFICER_NAME: VONKOLLMAR, DESIREE

PROJECT_TERMS: Algorithms;Alleles;Architecture;Archives;Area;Behavior;Binding;Biological;Biological Process;biological systems;Biomedical Research;Cells;Chemical Agents;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Collection;Communities;Complex;Computer software;COVID-19;CRISPR screen;Data;data pipeline;Data Set;data tools;Databases;Development;Discipline;Disease;Drug Interactions;Elasticity;Engineering;experimental study;functional genomics;fundamental research;Funding;Future;gene function;Generations;Genes;Genetic;Genome;genome-wide;Health;Human;Human Development;human disease;improved;interest;International;Intuition;Knowledge;knowledge graph;large datasets;Literature;Malignant Neoplasms;Maps;Methods;Mission;model organism;model organisms databases;Molecular;multicatalytic endopeptidase complex;new therapeutic target;novel;open source;Organism;Orthologous Gene;pathogen;Pathway Analysis;Phenotype;Post-Translational Protein Processing;Process;Property;protein complex;protein function;Protein Structure Initiative;Proteins;Proteome;Publications;Records;repository;Research;Research Personnel;Resources;Services;software development;Software Tools;Source;statistics;System;technological innovation;Technology;text searching;Tissues;tool;Translating;Translational Research;Ubiquitin;United States National Institutes of Health;Visualization;web site

PROJECT_TITLE: BioGRID: An open resource for biological interactions and network analysis

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Chronic Pain;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Pain Research;Prevention

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE  Cases of Alzheimer’s dementia (AD) will triple by 2050, making preventative intervention on health- focused risk factors a major goal. Of recent interest is chronic pain, recently linked to a doubled risk of AD. This study will provide clarification by examining associations of chronic pain with indicators of general neurodegeneration and AD-related neurodegeneration.

PI_NAMEs: BELL, TYLER REED (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: Address;Adult;Affect;Age;Aging;Alzheimer associated neurodegeneration;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;Amyloidosis;Animal Model;Animals;Automobile Driving;Biological;Biological Markers;Biological Process;Biology;Brain;Brain region;brain volume;California;career development;Chronic;chronic pain;Cognitive aging;Competence;Complement;Data;Data Set;Dementia;dementia risk;depressive symptoms;Diagnosis;Early Diagnosis;Education;Environment;ethnic minority;factor A;Female;follow-up;Framingham Heart Study;Goals;Health;Health Care Costs;Helping to End Addiction Long-term;high risk;Human;Impaired cognition;improved;innovation;interest;K-Series Research Career Programs;Knowledge;late life;Light;Link;locus ceruleus structure;Measures;Memory;Mentors;middle age;mild cognitive impairment;modifiable risk;multidisciplinary;multiple chronic conditions;multiple datasets;National Institute on Alcohol Abuse and Alcoholism;Nerve Degeneration;Neuroanatomy;neurofilament;neuroimaging;neuron loss;Neuronal Injury;novel;older adult;opioid use;Pain;Pain management;Pathologic;Persons;physical inactivity;Predisposition;preventive intervention;programs;Proteins;Psychiatry;Race;racial minority;religious order study;Research;Research Personnel;Retrospective Studies;Risk;Risk Factors;Risk Reduction;Sampling;secondary analysis;sex;skills;Statistical Data Interpretation;tau Proteins;Thick;Training;Training Activity;Twin Studies;United States;United States National Institutes of Health;Universities;Vietnam;Work

PROJECT_TITLE: Chronic Pain and Risk of Alzheimer's-Related Neurodegeneration

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB

PHR: Cryo-electron microscopy (cryo-EM) has already had a revolutionary impact on cell and molecular biology and become a major source of structural information. Still, the minimum number of parti- cles needed for a three-dimensional reconstruction of a structure, and the minimum size of the particles amenable to reconstruction, remains far above fundamental limits. Over the past four years, we have developed a laser-based phase-plate (LPP) that can contribute to reaching the standard quantum (shot-noise) limit of imaging in cryo-EM.

PI_NAMEs: MUELLER, HOLGER  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 12 year old;3-Dimensional;Apoferritin;arm;Automation;Biological;Biological Testing;Cellular biology;Classification;Coma;Communities;Compensation;contrast imaging;cost;Cryoelectron Microscopy;Data;Data Collection;data quality;Data Set;density;design;Development;Electron Beam;electron diffraction;Electron Microscope;Electron Microscopy;Electrons;Feedback;Frequencies;Goals;Guns;Human;Image;improved;Lasers;Manuals;Maps;Mechanics;Microscope;Microtubule-Associated Proteins;Modification;Molecular Biology;Molecular Conformation;Muramidase;Myoglobin;Noise;Optics;particle;Particle Size;Pattern;Performance;Phase;Proteins;quantum;reconstruction;Resolution;Source;Specimen;Speed;structural biology;Structure;Testing;Titan;tool;transmission process;user-friendly

PROJECT_TITLE: Development of Laser-Based Phase Contrast for Biological Electron Microscopy

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative An understanding of how neural circuitry produces behavior would provide important insights into the basis of brain disorders; however, the tools are lacking. The nematode Caenorhabditis elegans gives us the opportunity to study how an entire nervous system functions together to extract ecologically-relevant information about chemical stimuli, and to couch these analyses in the known structural connectivity between neurons. This project will establish a theoretical framework for understanding fine- grained, yet holistic neural processing in many neural systems using graph theory and information theory, and will enable us to understand how neural circuits work in health.

PI_NAMEs: HOW, JAVIER JOSUE (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Algorithms;Anatomy;Animals;Automobile Driving;Award;Behavior;Behavioral;behavioral response;Brain;Brain Diseases;Caenorhabditis elegans;Chemicals;Code;Communication;cost;design;Diacetyl;Ensure;experience;Future;Goals;Grain;Graph;graph theory;Head;Health;Individual;information model;information processing;Information Theory;insight;interest;Interneurons;Label;Link;Methods;Molecular;Motor;Movement;Names;Negative Valence;Nematoda;Nervous System;Nervous System Physiology;neural;neural circuit;neural patterning;Neurons;Neurosciences;novel;Odors;optogenetics;Organism;Pattern;Phase;Population;Positive Valence;Postdoctoral Fellow;Preparation;Process;Property;Publications;Research;Research Project Grants;Rest;sensory feedback;sensory stimulus;Signal Transduction;Stereotyping;Stimulus;System;Techniques;Testing;theories;Time;tool;Transgenic Organisms;transmission process;Work

PROJECT_TITLE: Developing Quantitative Methods to Reveal Neural Circuit Dynamics


ED_INST_TYPE: SCHOOLS OF NUTRITION

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Obesity;Pediatric;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: PROJECT NARRATIVE U.S. children fall short of physical activity recommendations, and innovative, practical strategies are needed to close the gap equitably. Policy recommendations promote school- and home-based interventions as well as programs that improve children's physical literacy – that is, their ability, confidence, and motivation to be physically active for life; yet no prior study has empirically tested a multilevel, PL-focused intervention for children. To fill this gap, this study will leverage a unique university/national non-profit partnership to design and test an innovative program that reaches children both at school and at home to improve their physical literacy and physical activity.

PI_NAMEs: HENNESSY, ERIN  (contact);SACHECK, JENNIFER

PROGRAM_OFFICER_NAME: PERNA, FRANK

PROJECT_TERMS: Accelerometer;Address;Affect;Area;arm;Boston;Child;Child Support;Communities;Competence;design;Development;disparity gap;Educational Curriculum;Effectiveness;efficacy testing;elementary school;Equity;Event;exercise intervention;experience;falls;Family;Feasibility Studies;feasibility trial;Female;fifth grade;Focus Groups;Goals;Home;implementation evaluation;implementation outcomes;implementation process;improved;Incentives;innovation;Intervention;Learning;Life;literacy;Literacy Programs;Literature;Low income;Measurement;Mediating;Methods;moderate-to-vigorous physical activity;Motivation;New York;New York City;Nonprofit Organizations;Obesity;Outcome Assessment;Overweight;Parents;Phase;Physical activity;Physical activity scale;pilot test;policy recommendation;primary caregiver;programs;Public Health;Random Allocation;randomized trial;randomized, controlled study;Randomized, Controlled Trials;Recommendation;Research;Research Design;Schools;sex;social media;socioeconomics;Strenuous Exercise;Students;success;Surveys;Testing;Text Messaging;theories;tool;Universities;Weight;Work;Youth

PROJECT_TITLE: Supporting Physical Literacy at School and Home (SPLASH) Study


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Sleep Research

ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: The proposed studies will provide new insights into how sleep uniquely contributes to long-term memory storage. This work has the potential to lead to targeted interventions for cognitive dysfunction induced by sleep loss, and interventions for psychiatric disorders where both sleep and cognition are adversely affected, including schizophrenia, depression, autism, post-traumatic stress disorder, and dementia.

PI_NAMEs: ATON, SARA J;ZOCHOWSKI, MICHAL R (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Acetylcholine;Affect;analytical method;analytical tool;Anatomy;Area;autism spectrum disorder;biophysical model;Brain;Cells;Cognition;Cognition Disorders;Cognitive;cognitive function;computational network modeling;Computer Models;data modeling;Dementia;density;Equilibrium;experience;experimental study;Generations;Goals;Hippocampus;Hour;Impaired cognition;in silico;in vivo;Individual;Information Storage;insight;Interneurons;Intervention;Learning;long term memory;Maps;Measures;Memory;memory consolidation;memory encoding;memory process;Mental Depression;Mental disorders;Modeling;Mus;Muscarinic Acetylcholine Receptor;National Institute of Mental Health;network models;neural circuit;neural network;Neural Network Simulation;neuronal excitability;Neurons;neuroregulation;Neurosciences;neurotransmission;Nicotinic Receptors;non rapid eye movement;novel;optogenetics;Pathway interactions;Pattern;phenomenological models;Physiology;Play;Population;Post-Traumatic Stress Disorders;Process;Property;recruit;REM Sleep;Research;response;Role;Schizophrenia;segregation;sensory input;Signal Transduction;Silicon Dioxide;Sleep;Sleep Architecture;Sleep Deprivation;Sleep disturbances;Somatostatin;Strategic Planning;Structure;Synapses;synaptic function;Synaptic plasticity;Testing;tool;Training;Work

PROJECT_TITLE: CRCNS: Acetylcholine and state-dependent neural network reorganization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-P(50)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences;Rehabilitation;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CINCINNATI

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Project Narrative Intracerebral hemorrhage (ICH) occurs when there is spontaneous bleeding into the brain, and it causes a high rate of death and serious disability, including progressive cognitive decline. Increasing evidence suggests that inflammation after ICH contributes to brain injury and clinical outcomes. Using specialized blood testing, this proposal seeks to understand which components of post-ICH inflammation affect patient outcomes, including functional outcome and the development of progressive cognitive decline. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

PI_NAMEs: WALSH, KYLE BRENDAN (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Address;Affect;Anti-Inflammatory Agents;Biological Markers;Black Populations;Blood;Blood Circulation;Blood specimen;Blood Tests;Brain;Brain Injuries;Cells;Cerebral hemisphere hemorrhage;Clinical;Clinical Research;Cognitive;cognitive recovery;cohort;cytokine;Data;Data Set;Death Rate;Development;differential expression;disability;disabled;Enrollment;Ethnic Origin;Evaluation;exosome;Extracellular Space;extracellular vesicles;Female;follow-up;Functional disorder;functional outcomes;Gene Expression;Gene Proteins;Genes;Goals;Hemorrhage;Hispanic Populations;Human;IL8 gene;Image;Impaired cognition;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;insight;Interleukin-8;Investigation;Leukocytes;Literature;male;Measures;Messenger RNA;Microglia;MicroRNAs;miRNA expression profiling;Molecular;monocyte;mortality;mRNA sequencing;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;neuroimaging;Neurons;Outcome;Pathology;Patient-Focused Outcomes;Patients;Peripheral;peripheral blood;Persons;Phenotype;Plasma;preclinical study;Process;Proteomics;Race;racial diversity;racial minority;Recovery;recruit;Regulator Genes;Reporting;Research;RNA;Sample Size;Sampling;Science;Severities;sex variable;Stroke;stroke recovery;study population;Survivors;systemic inflammatory response;Testing;transcriptome sequencing;transcriptomics;Untranslated RNA;Vascular Cognitive Impairment;vesicular release

PROJECT_TITLE: CAPSTONE: Central And Peripheral STrOke inflammatioN with Exosomes

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: PROJECT NARRATIVE Pancreatic cancer is an increasingly common disease with dismal outcomes, so better therapeutics are desperately needed. Our studies demonstrate that inhibition of the sterol regulatory element-binding protein pathway that controls lipid metabolism is a promising therapeutic target. In this proposal, we will identify potent chemical inhibitors of this pathway, enabling pre-clinical studies in pancreas cancer and motivating development of therapeutics for treating pancreas cancer patients.

PI_NAMEs: ESPENSHADE, PETER J. (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Binding Proteins;Biological;Biological Assay;Breast;Cancer Etiology;candidate identification;Cause of Death;cell growth;Cell Line;Cessation of life;chemical property;Chemicals;Cholesterol;Colon;Colon Carcinoma;cytotoxic;Data;Diagnosis;Diamines;Dipyridamole;Disease;Dose;Environment;Enzymes;Essential Genes;experimental study;Fatty Acids;Genes;Genetic;Glioblastoma;Goals;Growth;Growth and Development function;Heterozygote;high throughput screening;Human;Hypoxia;inhibitor;isoprenoid;KPC model;Lead;Libraries;lipid metabolism;Lipids;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;meetings;Membrane Lipids;Modeling;Mus;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel strategies;novel therapeutics;Nude Mice;Nutrient;Outcome;Oxygen;pancreatic cancer model;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Pathway interactions;Pharmaceutical Preparations;pharmacophore;preclinical study;prevent;Primary Neoplasm;Process;Property;Prostate;Proteins;Proteolysis;Pyrimidine;Regulatory Element;response;Role;Series;Solid Neoplasm;Sterols;subcutaneous;Survival Rate;Therapeutic;therapeutic candidate;therapeutic development;therapeutic target;Time;transcription factor;Triglycerides;tumor;tumor growth;tumor microenvironment;United States;uptake;Vascularization;Xenograft Model

PROJECT_TITLE: High Throughput Screening for SCAP Inhibitors as Pancreas Cancer Therapeutics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Y(56)R]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Pediatric;Physical Activity;Prevention;Rare Diseases

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: PROJECT NARRATIVE The Congenital Heart Disease Physical Activity Lifestyle intervention (CHD-PAL), which was designed to target elements of the Theory of Planned Behavior (TPB), has demonstrated feasibility/preliminary efficacy for increasing moderate-to-vigorous physical activity (MVPA) among adolescents and young adults (AYAs) with CHD who are less physically active; however, a larger trial is needed to determine efficacy for CHD-PAL. The current study aims to determine if CHD-PAL increases MVPA as compared to a more rigorous attention control comparator, examine durability of intervention effects, explore changes to the TPB hypothesized mechanisms, and explore the impact of CHD-PAL on biomarkers of cardiovascular health. The current study is the necessary next step in the refinement of CHD-PAL before dissemination to multiple sites for assessment of health implications and eventually the cost effectiveness of the intervention for AYAs with CHD, an understudied population.

PI_NAMEs: JACKSON, JAMIE L. (contact)

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: Accelerometer;Address;Adolescence;Adolescent and Young Adult;Adult;Affective;Age;aged;Aging;arm;attentional control;Attitude;Behavior;Behavior Therapy;Behavioral Mechanisms;Biological Markers;Cardiopulmonary;cardiorespiratory fitness;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Childhood;Chronic;Clinical;comorbidity;comparison control;Complex;Congenital Abnormality;congenital heart abnormality;Control Groups;Coronary Arteriosclerosis;cost effectiveness;design;Effectiveness of Interventions;efficacy evaluation;efficacy trial;Elements;exercise intervention;exercise prescription;Exercise stress test;expectation;Family;family support;fitbit;follow-up;Fostering;Frequencies;Gender;Goals;Health;health assessment;Health Care Costs;Hypertension;improved;Intervention;intervention effect;Life Style;lifestyle intervention;Measures;Metabolic;Modality;moderate-to-vigorous physical activity;Monitor;Morbidity - disease rate;optimism;Outcome;Outcome Study;Participant;Phase;Physical activity;Physiology;Planning Theory;Population;post intervention;Process;Randomized;Research;Risk;Schedule;secondary outcome;Self Efficacy;Site;social norm;Survivors;survivorship;Techniques;theories;Time;Videoconferencing;young adult

PROJECT_TITLE: Establishing Efficacy for the Congenital Heart Disease Physical Activity Lifestyle Intervention

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Bioengineering;Cancer;Coronaviruses;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Project Narrative In this project, we develop new molecular simulation methods that combine Markov State Model (MSM) and expanded-ensemble approaches. These tools can leverage the distributed computing power of Folding@home to make fundamental advances in computational drug discovery and molecular design that will lead to widespread benefits for human health. We apply these tools to understand and design new inhibitors of key cancer targets, including the PTEN tumor suppressor.

PI_NAMEs: VOELZ, VINCENT  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Address;Affinity;Binding;cluster computing;Collaborations;Colorado;computational platform;Computer Hardware;Computing Methodologies;coronavirus pandemic;cost;Coupled;Coupling;COVID-19;COVID-19 screening;crowdsourcing;Cyclic Peptides;Data;design;Dimerization;Dissociation;drug discovery;Drug resistance;Fox Chase Cancer Center;Free Energy;Funding;Health;Home;Human;improved;inhibitor;Joints;Ligand Binding;Ligands;machine learning classifier;Macrolides;Malignant Neoplasms;markov model;Methods;Modeling;models and simulation;Molecular;Molecular Conformation;Muramidase;mutant;Mutation;Natural Products;Neoplasm Metastasis;novel diagnostics;open data;Pathway interactions;Peptides;Physics;Population;Protease Inhibitor;Protein Dynamics;protein folding;Proteins;PTEN gene;Publishing;Reaction;receptor;Research;restraint;Role;Sampling;Series;simulation;Structure;System;Testing;Therapeutic;Thermodynamics;Time;tool;Toy;Tumor Suppressor Proteins;Universities;Variant;virtual screening;Work

PROJECT_TITLE: Markov State Model approaches for folding, binding and design

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Pneumonia and Influenza;Women's Health Research

PHR: Project Narrative Influenza causes millions of respiratory infections every year, but there are substantial differences in the susceptibility of each person to severe flu infection. Sex differences are a major contributor to this variation. This proposal will elucidate the genetic mechanisms underlying sex differences in influenza infection, define sex- specific biomarkers for flu severity, and provide a new computational resource for the research community.

PI_NAMEs: KO, DENNIS CHUN-YONE (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 1918 influenza pandemic;African;Alleles;Area;Asian;Bacterial Infections;biobank;Biological Markers;candidate identification;Cell Line;Cell model;Cells;Cessation of life;Child;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;Communicable Diseases;Communities;Complex;computational pipelines;Computer Analysis;Computing Methodologies;computing resources;constitutive expression;Coupled;Curettage procedure;data dissemination;Data Set;Databases;Development;diagnostic strategy;differential expression;Disease;Environment;European;Exhibits;experience;Female;Female of child bearing age;flu;Gene Expression;Gene Expression Profile;gene interaction;Genes;Genetic;Genetic Transcription;Genetic Variation;genome wide association study;Genotype;Goals;Heterogeneity;Hospitalization;Human;Human Genetics;Hypoxia;Immune response;In Vitro;Individual;Infection;Influenza;Influenza A virus;influenza infection;Information Dissemination;insight;Integration Host Factors;Internet;Link;lymphoblastoid cell line;Machine Learning;male;Measures;Modeling;multidisciplinary;Nose;novel diagnostics;novel therapeutic intervention;Older Population;Outcome;overexpression;pandemic disease;peripheral blood;Persons;Phenotype;Population;Predisposition;Publishing;Quantitative Trait Loci;Research;Resolution;Resources;Respiratory Tract Infections;response;Risk;RNA Interference;RNA interference screen;RNA Splicing;Sampling;SARS coronavirus;Severities;sex;Sex Bias;Sex Differences;small molecule;specific biomarkers;Symptoms;Testing;Time;Transcript;transcriptomics;Tube;United States;Validation;Variant;Viral;Virus Diseases;virus genetics;Virus Replication;volunteer;web-based tool

PROJECT_TITLE: Genetic Contributors to the Impact of Sex on Heterogeneity in Flu Infection


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Primary Health Care;Social Determinants of Health;Telehealth

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE/RELEVANCE This project will develop novel methods to capture the increasing specialization of physicians in the US based on their observed practice patterns, describe patterns in subspecialization over time and geography, and assess the impact of subspecialization on health outcomes for older adults. The results from this work will provide novel evidence to guide health policy for the aging population, including improved methods to accurately measure specialty supply, evidence to guide health insurers and policymakers for applications such as determining adequacy of specialist coverage in insurance design (e.g., Medicare Advantage), data for identifying populations with shortages in subspecialist access, and evidence for guiding development of telemedicine infrastructure. This understanding will be crucial for policies regarding the growth and distribution of subspecialty expertise and technologies to implement the National Institute on Aging’s mission of improving the health and well-being of older Americans.

PI_NAMEs: BARNETT, MICHAEL LAWRENCE (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;aging population;Algorithms;American;aortic valve replacement;Area;Atrial Fibrillation;Awareness;beneficiary;Blood Vessels;Board Certification;Cardiac ablation;Cardiac Electrophysiologic Techniques;Cardiology;care fragmentation;Caring;Certification;Characteristics;chemotherapy;Chronic;Classification;Clinical;Communities;comorbidity;Data;Databases;Defibrillators;design;Detection;detection method;Development;Diagnosis;Directories;Discipline;Drug Prescriptions;Gatekeeping;Geographic Factor;Geography;graduate medical education;Growth;Health;Health Policy;Health Services Accessibility;Health system;Healthcare;Heart failure;improved;improved outcome;Individual;Inequity;Infrastructure;Insurance;Insurance Carriers;Intervention;Malignant Breast Neoplasm;Measures;Medicaid eligibility;Medical Oncology;medical specialties;Medical Technology;Medicare;Medicare claim;member;Methods;Mission;Modeling;National Institute on Aging;novel;Office Visits;older adult;Oncologist;Operative Surgical Procedures;Outcome;overtreatment;Patients;Pattern;Personal Satisfaction;Pharmacotherapy;Physician's Practice Patterns;Physicians;Policies;Policy Maker;Population;Primary Care;Primary Care Physician;primary care practice;Quasi-experiment;Science;Services;socioeconomics;Specialist;Specialty Boards;Surgical Oncology;Surgical Specialties;Technology;Telemedicine;Time;tool;Tracer;Work

PROJECT_TITLE: Physician Subspecialization and the Health and Health Care of Older Americans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-G(90)S]


NIH_SPENDING_CATS: Cancer;Genetics;Radiation Oncology

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: NARRATIVE. Chromosomal-breaking agents (i.e. clastogens), including ionizing radiation, remain a cornerstone of cancer therapy; nevertheless, their efficacy could be improved by inhibiting the repair of chromosomal breaks in cancer cells. Indeed, inhibitors of the DNA-dependent protein kinase catalytic subunit (DNAPKcs) are being developed for this approach; but to identify the ideal contexts for using such inhibitors, it is critical to understand the role of DNAPKcs in chromosomal break repair. Thus, our proposed studies to elucidate the mechanisms of DNAPKcs function during chromosomal break repair will support the mission of the NIH to improve cancer treatments and patient outcomes.

PI_NAMEs: STARK, JEREMY MICHAEL (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Address;Binding;Biological Assay;Biological Markers;biomarker development;cancer cell;cancer therapy;Cells;Chromosomal Breaks;Chromosomes;clastogen;Clinical Trials;Code;cofactor;Combined Modality Therapy;Complex;Data;Defect;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA replication fork;DNA-dependent protein kinase;DNA-PKcs;Double Strand Break Repair;Ensure;Event;experimental study;G22P1 gene;Genetic;Genome;Genome Stability;Genomic Instability;Human;improved;inhibitor;innovation;insertion/deletion mutation;insight;Ionizing radiation;kinase inhibitor;Laboratories;Lasers;Ligase;Magnetic Resonance Imaging;Maintenance;Measures;Mediating;Mission;Modeling;mutant;Mutation;Nonhomologous DNA End Joining;novel;nuclease;Outcome;Pathway interactions;Patient-Focused Outcomes;Phosphotransferases;Play;Poly(ADP-ribose) Polymerase Inhibitor;PRKDC gene;PTEN gene;radiation resistance;Radiation therapy;recruit;Regulation;repaired;replication stress;Reporting;Resistance;response;response biomarker;Ribosomal RNA;RNA Processing;Role;scaffold;Series;Signal Transduction;Site;synergism;Technology;Testing;therapeutic target;Time;Treatment outcome;Treatment Protocols;treatment strategy;tumor;Tumor Suppressor Proteins;United States National Institutes of Health;V(D)J Recombination;XRCC4 gene;XRCC5 gene

PROJECT_TITLE: Elucidating the role of DNAPKcs in chromosomal break end joining and clastogen resistance

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Lymphatic Research;Rare Diseases;Regenerative Medicine;Scleroderma

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: To improve treatment options for patients with scleroderma (SSc), a better understanding of the molecular and cellular mechanisms that cause the vascular defects of the disease is needed. We propose to determine the contribution of transcriptional factor ERG to the phenotypic changes in SSc blood and lymphatic vasculature and functionally test how the absence of ERG affects the processes of physiological and pathological angiogenesis.

PI_NAMEs: TROJANOWSKA, MARIA  (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Address;Affect;angiogenesis;Animals;Autoimmunity;Automobile Driving;Bleomycin;Blood;Blood Cells;Blood Vessels;Body System;Cause of Death;CCL21 gene;Cell Physiology;Cell Proliferation;Cell secretion;Cells;Cutaneous sclerosis;Data;Defect;Dendritic Cells;Development;Disease;Endothelial Cells;Endothelium;experimental study;Family;Feedback;Fibrosis;FLT4 gene;Functional Regeneration;Gene Expression Profiling;Genes;Genetic Transcription;Goals;Homeostasis;Immune;Impaired wound healing;Impairment;improved;In Vitro;in vivo;Inflammatory;Injury;Intercellular Junctions;Knock-out;Knowledge;Lymphangiogenesis;Lymphatic;lymphatic circulation;lymphatic dysfunction;Lymphatic Endothelial Cells;Lymphatic Endothelium;Lymphatic System;lymphatic vasculature;lymphatic vessel;Lymphocyte;matrigel;member;Molecular;Molecular Target;mouse model;Mus;Natural regeneration;NOTCH1 gene;NOTCH4 gene;novel;Organ;Pathologic;Pathologic Neovascularization;Pathway interactions;Patients;Phenotype;Physiologic Neovascularization;Physiological;Physiological Processes;Platelet Activation;postnatal;Predisposition;prevent;programs;Proliferating;Publishing;Pulmonary Fibrosis;receptor;repaired;response;response to injury;Role;Sampling;Scleroderma;Serum;Signal Pathway;Signal Transduction;Signaling Molecule;Skin;skin biopsy;skin fibrosis;SOX18 gene;Specific qualifier value;Systemic Scleroderma;targeted treatment;Testing;Therapeutic Intervention;therapeutic target;Toxic Environmental Substances;transcription factor;Translations;Tube;Variant;Vascular Diseases;Vascular Endothelial Cell;Vascular Endothelial Growth Factor Receptor-3;vascular inflammation;vascular injury;Vascular System;VEGFC gene;wound healing

PROJECT_TITLE: Lymphatic ERG signaling in scleroderma fibrosis


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Lung;Lung Cancer;Precision Medicine

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE  Over the past ~15 years there has been tremendous progress in the treatment of lung cancer with EGFR mutations with targeted therapies. However, even the newest agents are not curative and there is variability in the depth and durability of responses. The goal of this research is to provide insight into the genetic mechanisms that modulate the growth and sensitivity to therapy of EGFR mutant lung tumors to eventually identify better potential therapeutic strategies for this disease.

PI_NAMEs: POLITI, KATERINA ABIGAIL (contact);WINSLOW, MONTE MEIER

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Biology;cancer cell;Cell Line;Cessation of life;Clinical Data;clinical investigation;Combined Modality Therapy;CRISPR/Cas technology;Data;Dedications;Disease;drug sensitivity;Environment;Epidermal Growth Factor Receptor;Event;experimental study;gene editing technology;gene function;Genetic;Genetic Determinism;Genomics;Genotype;Goals;Growth;Human;in vivo;in vivo Model;innovation;insight;Link;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Methods;Modeling;Molecular;mouse model;Mus;mutant;Mutation;novel;Oncogenic;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;Pharmacogenomics;Positioning Attribute;Precision therapeutics;programs;Research;Research Personnel;Resistance;response;RNA Splicing;Role;somatic cell gene editing;STK11 gene;synthetic lethal interaction;System;targeted treatment;Therapeutic;Therapeutically Targetable;TP53 gene;treatment response;tumor;tumor barcoding and sequencing;tumor growth;Tumor Suppression;Tumor Suppressor Genes;Tumor Suppressor Proteins;tumorigenic;Tyrosine Kinase Inhibitor;Work

PROJECT_TITLE: Genetic Determinants of Tumor Growth and Drug Sensitivity in EGFR Mutant Lung Cancer

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Pediatric;Prevention;Serious Mental Illness;Sleep Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: This study plans to validate an existing “risk calculator” (RC), a mathematical tool that can help predict mood recurrences and whether the recurrence is depression or mania. The existing RC only predicts risk between 1 and 5 years, but not imminent risk (1-4 weeks before recurrence). To do this, we are going to evaluate whether data obtained from a smartphone application that continuously measures sleep-activity rhythms, mobility, and digital social interactions will enhance the RC to predict the immediate risk of a recurrence and thus, enable clinicians to intervene promptly before the recurrence occurs.

PI_NAMEs: BIRMAHER, BORIS  (contact)

PROGRAM_OFFICER_NAME: KING, ERIN MICHELE

PROJECT_TERMS: Accelerometer;actigraphy;Address;Adolescence;Adolescent;Adult;Age;aged;Behavior;behavior change;Biological;Bipolar Disorder;Cellular Phone;Clinical;Clinical assessments;clinical practice;clinical predictors;Communication;Counseling;Data;data integration;Detection;Development;digital;Discrimination;Disease remission;Distal;Early Diagnosis;emerging adult;Evaluation;Family;Family history of;follow-up;functional improvement;Future;Gold;Grain;improved;Individual;individualized medicine;instrument;Intake;interest;Intervention;Manic;Maps;Mathematics;Measures;Medicine;Mental Depression;Methods;Modeling;Monitor;mood symptom;Moods;Outcome;Participant;Patient Participation;Patient Self-Report;Patients;Persons;Pharmaceutical Preparations;Populations at Risk;prevent;Problem behavior;Prognosis;psychosocial;Questionnaires;recruit;Recurrence;Recurrence Score;Research;Risk;Risk Factors;risk prediction;Sampling;sex;Sleep;Sleep disturbances;smartphone application;Social Interaction;Substance abuse problem;suicidal risk;Suicide;Telephone;Testing;Text Messaging;Time;time use;tool;young adult;Youth

PROJECT_TITLE: Predicting Recurrences in Bipolar Illness (Prompt-BD)

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Cancer;Climate-Related Exposures and Conditions;Prevention;Skin Cancer

ORG_CITY: POMONA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: WESTERN UNIVERSITY OF HEALTH SCIENCES

PHR: Overexposure to UV radiation causes skin damage, inflammation, defective immunity, and development of skin cancer, which is the most common cancer in the US and the world. The β-blocker carvedilol prevents UV-induced skin cancer by attenuating DNA damage and skin inflammation and reversing immunosuppression, and our recent data indicate that the non-β-blocking enantiomer R-carvedilol shows the same effects without disturbing the cardiovascular system. Studies are proposed in this application to determine the molecular target, safety and delivery of R-carvedilol, which will not only provide valuable information about repurposing a β-blocker as a topical prophylactic medication for cancer, but also lead us to identify new targets for cancer chemoprevention.

PI_NAMEs: HUANG, YING  (contact)

PROGRAM_OFFICER_NAME: VLAD, ANDA MIOARA

PROJECT_TERMS: absorption;Adrenergic beta-Antagonists;Affect;Animal Experiments;antagonist;anti-cancer;Applications Grants;AR gene;beta-adrenergic receptor;Biological Availability;Blood Pressure;Bradycardia;Calcium;Calcium Channel;cancer chemoprevention;cancer type;carcinogenesis;carcinogenicity;Carcinogens;Cardiovascular Agents;Cardiovascular Diseases;cardiovascular effects;Cardiovascular system;carvedilol;Cell Culture Techniques;Chemoprevention;Chemopreventive Agent;Chronic stress;Clinical;Clinical Research;Data;Development;DNA Damage;Dose;drug candidate;Drug Targeting;Drug usage;enantiomer;Ensure;Exposure to;FDA approved;Gel;Gene Deletion;Goals;Hemorrhage;Human;human subject;Immune system;Immunity;Immunosuppression;Impairment;In Vitro;in vivo;Inbred HRS Mice;Incidence;Individual;Infection;Inflammation;knockout gene;Lesion;Malignant Neoplasms;Mediating;Melanoma;Metabolism;Methods;Molecular Target;Morbidity - disease rate;mortality;mouse model;Mus;nano;Nanodelivery;novel;Operative Surgical Procedures;Oral;Outcome;Persons;Pharmaceutical Preparations;Physiological;Predisposition;prevent;Prevention;Prevention approach;Preventive;Procedures;Property;prophylactic;Regimen;Risk;Role;Ryanodine Receptor Calcium Release Channel;Safety;side effect;Skin;Skin Cancer;skin cancer prevention;Skin Carcinogenesis;Skin Carcinoma;skin damage;skin organogenesis;Sunburn;System;Testing;Time;Topical application;Transgenic Mice;Translating;ultraviolet;Ultraviolet B Radiation;Ultraviolet Rays;UV carcinogenesis;UV induced;UV induced DNA damage;UV Radiation Exposure;Vision;weapons

PROJECT_TITLE: Preventing UV-induced immunosuppression and skin carcinogenesis with R-carvedilol

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Immunotherapy;Microbiome;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: Project Narrative: Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second deadliest cancer by 2030. We recently showed that TH2 cells produce type 2 cytokines (IL4 and IL13) that provide trophic support to PDAC tumorigenesis. In this proposal, we aim to understand the mycobiome mediated cancer cell-TH2 axis and explore the therapeutic potential of inhibiting this axis for PDAC treatment.

PI_NAMEs: DEY, PRASENJIT  (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Allergic Disease;Alternaria;anti-fungal agents;Antibodies;asthma exacerbation;asthmatic patient;Biological;Biology;cancer cell;CD4 Positive T Lymphocytes;cell injury;Cell Line;Cells;Clinical;clinical development;Clinical Research;clinically relevant;Combined Modality Therapy;cytokine;Cytokine Signaling;Development;Disease;effective therapy;Epithelium;experimental study;extracellular;Foundations;fungal microbiota;Fungal Spores;fungus;Future;Genetically Engineered Mouse;Human;IL4 gene;IL5 gene;Immune;immune checkpoint;Immune checkpoint inhibitor;immune modulating agents;Immune response;Immunoprecipitation;Immunotherapy;immunotherapy trials;improved;Infiltration;Inflammatory;insight;Interleukin-13;Knock-out;Knowledge;KRASG12D;Lung;Lung Diseases;Lymphoid Cell;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Mediating;Modeling;Molecular;Monoclonal Antibodies;mouse model;Mus;mycobiome;Mycoses;neoplastic cell;neutralizing antibody;Normal Cell;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Oncogenes;Oral;Organoids;overexpression;P2Y2 receptor;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pathway interactions;Patients;Pattern;Peptide Hydrolases;pharmacologic;Play;pre-clinical;Pre-Clinical Model;Proliferating;Proteomics;receptor;recruit;Regulatory T-Lymphocyte;Reporting;Research;Ribosomal RNA;Role;Sampling;Serum;Signal Transduction;Sphincter of Oddi structure;Subcellular Fractions;Survival Rate;Testing;Th2 Cells;Therapeutic;therapy resistant;Transplantation;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-infiltrating immune cells;tumorigenesis;validation studies;Work

PROJECT_TITLE: Role of type 2 immune response in pancreatic cancer tumorigenesis

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative  Lymphoid malignancies are primarily tumors of B cell origin and will be responsible for approximately 150,000 new cases of cancer and 40,000 deaths in the USA in 2020. While responses in advanced B cell tumors treated with chimeric antibody receptor (CAR)-expressing T cells have been remarkable for some people, many patients do not respond to this treatment. This proposed research will explore how manipulating signaling through the type I interferon receptor chain subunit 1 (IFNAR1), a key molecule for T cell activation, function and proliferation can be harnessed to improve CAR T cell therapy for patients with B cell tumors.

PI_NAMEs: ATHERTON, MATTHEW JOHN (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Adoptive Cell Transfers;anti-tumor immune response;Antigens;Autologous;Award;B lymphoid malignancy;B-Cell Lymphomas;B-Cell Neoplasm;B-Lymphocytes;Biological;Blood Component Removal;blood product;Cancer Patient;cancer therapy;Canis familiaris;career development;CD19 gene;Cell Count;Cell Separation;Cell surface;Cell Therapy;Cells;Cessation of life;chimeric antibody;Chronic Lymphocytic Leukemia;Classification;Clinical;clinical predictors;Clinical Trials;cytokine release syndrome;Data;Development;Development Plans;Down-Regulation;efficacy evaluation;Engraftment;Enrollment;Exposure to;Fc Receptor;Fever;Foundations;Future;Generations;Genetic;genetic signature;Human;Immune response;Immunologics;Immunology;Immunotherapeutic agent;improved;improved outcome;In complete remission;In Vitro;in vivo;Infusion procedures;inhibitor;innovation;insight;Interferon Receptor;Interferon Type I;Interferons;Knowledge;large cell Diffuse non-Hodgkin's lymphoma;Malignant lymphoid neoplasm;Malignant Neoplasms;manufacture;Measurable;Mediating;Memory;Modeling;mouse model;Mus;mutant;Neoplasms;Oncologist;Outcome;p38 Mitogen Activated Protein Kinase;Patient-Focused Outcomes;Patients;Pennsylvania;Persons;pharmacologic;Phenotype;Pilot Projects;pilot trial;Play;pre-clinical;pre-clinical assessment;Pre-Clinical Model;preclinical efficacy;Primary Neoplasm;prognostic;prognostic indicator;prognostic significance;Proliferating;Publishing;Refractory;Research;response;Rodent;Safety;safety assessment;Scientist;Secure;Signal Transduction;skills;Solid;success;Surface;T memory cell;T-Cell Activation;T-Cell Development;T-Cell Proliferation;T-Cell Receptor;T-Cell Receptor Therapy;T-Lymphocyte;Techniques;Testing;Therapeutic;Traction;Training;trait;Treatment Efficacy;trial design;tumor;tumor progression;Tumor-Infiltrating Lymphocytes;type I interferon receptor;Ubiquitination;Universities

PROJECT_TITLE: Prognostic and Therapeutic Implications of IFNAR1 Signaling on CAR T Cell Therapy for Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: SALT LAKE CITY

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Type 1 diabetes mellitus (T1DM) is associated with significant patient burden, and environmental factors are thought to trigger disease onset. Modifying these exposures may offer safe and cost-effective approaches to prevent or delay T1DM; however, the timing and combination of exposures that contribute to T1DM etiology are poorly understood. This study aims to identify temporal sequences of exposures that contribute to T1DM with the long-term goal of improving the clinical translatability of exposure modification in T1DM prevention.

PI_NAMEs: MISTRY, SEJAL  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Address;Antigens;Autoantibodies;Autoimmune Diseases;Beta Cell;biomedical informatics;burden of illness;Child;Childhood;chronic autoimmune disease;Clinical;clinical center;clinical training;clinical translation;Complex;computer framework;Computing Methodologies;cost effective;Data;Data Collection;data mining;design;Development;Diabetes Mellitus;Disease;disorder prevention;Endocrinology;Environmental Exposure;Environmental Risk Factor;Etiology;experience;First Degree Relative;Functional disorder;Genetic Risk;Glucose;Glutamate Decarboxylase;Goals;Heterogeneity;Household;immune activation;Immune mediated destruction;improved;Individual;Infection;insight;Insulin;Insulin-Dependent Diabetes Mellitus;Investigation;islet;islet cell antibody;Joints;Knowledge;Machine Learning;Measurement;Mentorship;Methods;Mining;Modeling;Modification;Monitor;Natural History;nutrition;Onset of illness;Patients;Pattern;Pediatrics;Physicians;Populations at Risk;Positioning Attribute;prevent;Prevention;Prevention strategy;Prospective, cohort study;Protein Tyrosine Phosphatase;Psychosocial Factor;Risk;Role;Scientist;sex;Staging;Standardization;Symptoms;Testing;Training;Universities;Utah;Work

PROJECT_TITLE: Identifying Temporal Sequences of Exposures in Type 1 Diabetes Etiology