ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Neurosciences;Rehabilitation;Substance Misuse

ORG_CITY: TULSA

ORG_NAME: LAUREATE INSTITUTE FOR BRAIN RESEARCH

ORG_STATE: OK

PHR: PROJECT NARRATIVE Clinically significant anxiety and depression symptoms co-occur in nearly half of individuals seeking treatment for alcohol use disorder and reduce one's likelihood of responding to current treatments. Reductions in positive valence processing, including the experience of and response to positive emotions and situations, are often observed for both alcohol use disorder and anxiety/depression and relate to worse clinical outcomes. The proposed study will (a) further develop and refine a novel behavioral intervention, Amplification of Positivity for alcohol use disorder and co-occurring anxiety and depression (AMP-A), using both clinician and participant feedback and (b) examine the impact of AMP-A on self-reported positive valence processing, as well as clinical symptoms related to alcohol use, anxiety, and depression.

PI_NAMEs: AUPPERLE, ROBIN L (contact);TAYLOR, CHARLES

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: acamprosate;Address;Adverse effects;Affect;alcohol abuse therapy;Alcohol consumption;alcohol intervention;alcohol use disorder;Alcohols;Anxiety;anxiety symptoms;associated symptom;Awareness;Behavior Therapy;Binding;Clinical;Clinical Trials;clinically significant;Cognitive Therapy;contingency management;Corpus striatum structure;Data;depressive symptoms;design;Diagnosis;Diagnostic;efficacy evaluation;Evidence based treatment;Exhibits;experience;Feasibility Studies;feasibility testing;Feedback;follow-up;Functional disorder;Future;Goals;Health;improved;improved outcome;Individual;Intervention;Learning;Life;Maintenance;Measures;Mental Depression;Naltrexone;National Institute on Alcohol Abuse and Alcoholism;negative affect;Negative Valence;neural circuit;Neurosciences;non-drug;novel;Outcome;Participant;Patient Self-Report;Patients;Personal Satisfaction;pharmacologic;Pilot Projects;positive emotional state;Positive Reinforcements;Positive Reinforcer;Positive Valence;primary outcome;Process;Prognosis;Protocols documentation;psychosocial resources;Public Health;Randomized;recruit;reinforcer;remediation;Reporting;response;reward processing;Rewards;satisfaction;secondary outcome;social;Source;Stress;success;symptom treatment;Symptoms;System;Target Populations;Testing;therapy development;Treatment Efficacy;Waiting Lists;Well in self;Work

PROJECT_TITLE: Developing and Evaluating a Positive Valence Treatment for Alcohol Use Disorder with Anxiety or Depression


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Bioengineering;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Disability Research;Hematology;Nanotechnology;Neurosciences;Orphan Drug;Rare Diseases;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stroke

ORG_CITY: ATLANTA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_FIPS: US

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: The proposed research is relevant to public health because it will delineate mechanisms by which sickle cell disease, the most common inherited blood disorder in the U.S., causes accelerated damage to arteries in children and adults which can lead to devastating mental and physical disabilities, and even death, predominantly affecting a racial minority in the United States, but millions globally. Identifying proteolytic culprits, effects on the biomechanics of the vessels, and physiological consequences will provide new strategies to protect the vasculature of people born with this genetic disease, improving their quality of life, which is relevant to NIH’s mission of enhancing health, lengthening life, and reducing illness and disability.

PI_NAMEs: BOTCHWEY, EDWARD A. (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: 5 year old;Acceleration;Adult;Affect;African;Age;age difference;Age Months;age related;Aging;Aneurysm;Angiography;anterior cerebral artery;Arterial Disorder;arterial remodeling;arterial stiffness;Arteries;Atherosclerosis;Autopsy;Biochemical;Biomechanics;Biomedical Engineering;Blood Vessels;Bone Marrow;Bone Marrow Transplantation;Brain hemorrhage;carboxypeptidase C;Cardiovascular Diseases;Cardiovascular system;Carotid Arteries;cathepsin K;Cathepsins;cerebrovascular;Cessation of life;Child;Chronic;Collagen;collagenase;Cysteine;Data;disability;Disease;Disease Progression;efficacy evaluation;Elastases;Elasticity;Elastin;Endothelial Cells;Future;Genetic Diseases;Genetic Models;Genotype;Goals;Health;Hematological Disease;Hemorrhage;Heterozygote;high risk;Human;human disease;improved;Individual;Inflammation;Inflammatory;Inherited;inhibitor;Injections;innovation;Internal carotid artery structure;Intervention;Ischemic Stroke;JUN gene;Knowledge;Life;Life Expectancy;Link;Liquid substance;Magnetic Resonance;Maintenance;MAPK8 gene;Mechanics;Mediating;Mental disability;Microcirculation;middle cerebral artery;Mission;Modeling;Molecular;Monitor;Monocytosis;Morphology;mouse model;Mus;nanoparticle;nanoparticle delivery;Nanotechnology;new therapeutic target;novel;novel therapeutics;Outcome;Paper;Pathologic;Pathology;Patients;Peptide Hydrolases;Peripheral Blood Mononuclear Cell;Persons;pharmacologic;Pharmacologic Substance;physically handicapped;Physiological;postcapillary venule;predictive marker;preservation;prevent;Proteins;Public Health;Publishing;Quality of life;racial minority;Regulation;Research;Research Personnel;response;Risk;Role;shear stress;Sickle Cell;Sickle Cell Anemia;Signal Pathway;Signal Transduction;SP600125;Specimen;Stenosis;Stroke;stroke risk;Structure;success;Testing;Thinness;TNF gene;Transcription Factor AP-1;Transgenic Mice;Transgenic Organisms;United States;United States National Institutes of Health;Vascular Diseases;Wild Type Mouse;Work

PROJECT_TITLE: Artery biomechanics and vascular damage in sickle cell disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-D(02)M]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: Newark

ORG_DEPT: BIOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: The goal of this program is to train the next generation of translational researchers in cancer metabolism, growth, and host interaction mechanisms for an understanding of cancer at both tumor and host level. Better understanding of these mechanisms is critical for developing effective therapeutic strategies to target cancer.

PI_NAMEs: KANG, YIBIN ;ZONG, WEI-XING  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: host neoplasm interaction;post-doctoral training;Training Programs;tumor metabolism

PROJECT_TITLE: Post-doctoral Training Program in Cancer Metabolism and Tumor-host Interactions

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Genetics;Health Services;Human Genome;Prevention

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Payer coverage and economic value continue to be critical factors in determining whether genomic medicine is appropriately and efficiently implemented into clinical care and health policies. However, genomic tests are now emerging that present particularly difficult challenges for coverage and value determinations because they (a) will be used for screening and early detection in asymptomatic populations in addition to disease management in patients with a condition, and (b) use less-transparent methods, such as algorithmic scores, to establish linkages between genetic markers and disease. Our objective is to assess payer coverage decisions and the economic value of two types of emerging genomic tests for disease management and screening: cell-free DNA tests and tests based on polygenic risk scores.

PI_NAMEs: PHILLIPS, KATHRYN A (contact)

PROGRAM_OFFICER_NAME: CHANG, CHRISTINE Q

PROJECT_TERMS: Address;Adopted;Algorithms;Categories;cell free DNA;Center for Translational Science Activities;Clinical;clinical care;clinical implementation;Clinical Services;Collaborations;Complex;Coronary Arteriosclerosis;Development;development policy;Disease Management;Disparity;Early Diagnosis;economic evaluation;economic outcome;economic value;Ecosystem;Equity;evidence base;Funding;Genetic Diseases;Genetic Markers;Genomic medicine;Genomics;Government;Grant;Health;health care service organization;Health Policy;Health Services Research;improved;Industry;insight;Interview;Malignant Neoplasms;Methodology;Methods;Modeling;multidisciplinary;Outcome Study;patient oriented;Patient-Focused Outcomes;Patients;performance tests;personalized medicine;Policies;Policy Analysis;Policy Research;polygenic risk score;Population;Research;screening;stakeholder perspectives;Structure;Testing;United States National Institutes of Health;Work

PROJECT_TITLE: BUILDING THE EVIDENCE BASE FOR APPROPRIATE AND EFFICIENT IMPLEMENTATION OF EMERGING GENOMIC TESTS FOR DISEASE MANAGEMENT AND SCREENING


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: BALTIMORE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: This proposal seeks to elaborate how DNA repair enzymes protect against mutations caused by damage (deamination) occurring to 5-methylcytosine (mC), a modified DNA base that has essential functions in regulating gene expression. A large fraction of point mutations in cancer and genetic disease are attributable to mC deamination. The studies will reveal how repair enzymes counter this threat and inform why these mutations are still prevalent in human DNA. The studies will also reveal how these enzymes contribute to regulating the levels of DNA methylation (mC), which is important because aberrant DNA methylation is implicated in diseases including cancer, and in ageing.

PI_NAMEs: DROHAT, ALEX C (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Aberrant DNA Methylation;Aging;Animals;Archaea;Bacteria;base;Base Excision Repairs;Binding;Cytosine;Deamination;demethylation;Disease;DNA;DNA glycosylase;DNA Methylation;DNA Repair Enzymes;Ensure;enzyme activity;Enzymes;Epigenetic Process;epigenetic regulation;Excision;Face;Gene Expression;Genetic Diseases;genome integrity;Genomics;Goals;Guanine;Health;Human;human disease;human DNA;In Vitro;interest;Learning;Malignant Neoplasms;Mammals;Mediating;Methylation;Modeling;Modification;Mutation;Nature;novel therapeutic intervention;oxidation;Pathway interactions;Plants;Point Mutation;Polymerase;Post-Translational Protein Processing;Process;recruit;repair enzyme;repaired;Research;Site;Specificity;Sumoylation Pathway;System;Testing;Thymine;Uracil;Vertebrates

PROJECT_TITLE: Mechanisms of BER in Genomic Integrity and Epigenetic Regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Rare Diseases

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: We propose to investigate how the molecular activities of CPEB and FMRP, in their control of RNA expression, regulate neural function. Because ablation of CPEB and FMRP lead to neurodevelopmental disorders including autism and Fragile X Syndrome, our work is directly related to human health.

PI_NAMEs: RICHTER, JOEL D (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: 3' Untranslated Regions;Ablation;Affect;Alternative Splicing;Animal Behavior;Area;autism spectrum disorder;Behavioral;Binding;Brain;Chromatin;Codon Nucleotides;Cognition;Cytoplasm;Electrophysiology (science);Epigenetic Process;Event;Excision;experimental study;FMR1 gene;Fragile X Syndrome;Functional disorder;Genes;Genetic Transcription;Growth;Health;Human;Knockout Mice;Laboratories;Lead;Learning;Length;Link;Mediating;Memory;Messenger RNA;Minority;Molecular;mouse model;mRNA Precursor;mRNA Translation;Mus;nanopore;Neurodegenerative Disorders;Neurodevelopmental Disorder;neuropathology;Neurophysiology - biologic function;neuroregulation;Nucleotides;Poly(A) Tail;Polyadenylation;Post-Transcriptional Regulation;postsynaptic;Protein Isoforms;Proteins;Regulation;Research;Resolution;ribosome profiling;Ribosomes;RNA;RNA Degradation;RNA Splicing;RNA Stability;RNA-Binding Proteins;Synapses;synaptic function;Synaptic plasticity;transcriptome sequencing;Translation Initiation;Translational Regulation;Translations;Work

PROJECT_TITLE: RNA Control of Neural Function

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Cardiovascular;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Microbiome;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: CORAL GABLES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE The Miami MACS-WIHS will recruit 500 men and women with HIV and at risk for HIV who are representative of the Miami HIV epidemic. Data obtained will contribute to a greater understanding of the clinical and behavioral outcomes of HIV related comorbidities and health care disparities.

PI_NAMEs: ALCAIDE, MARIA LUISA (contact);FISCHL, MARGARET A;JONES, DEBORAH LYNNE

PROGRAM_OFFICER_NAME: PATHAK, ELIZABETH BARNETT

PROJECT_TERMS: Address;Affect;amyloid pathology;antiretroviral therapy;Area;Award;base;behavior prediction;Behavioral;behavioral outcome;Biological;Biological Markers;Bisexual;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Cells;Clinical;clinical research site;cohort;Cohort Studies;Collaborations;Communities;comorbidity;Consent;Consequences of HIV;Country;Data;data centers;Data Collection;Development;Disease Outcome;Disease Progression;Enrollment;Epidemic;ethnic minority;Exposure to;Female genitalia;Florida;follow-up;Fostering;Frequencies;Funding;genital microbiome;Goals;gut microbiome;health care disparity;Health Policy;Heterosexuals;Hispanic;HIV;HIV Infections;Immune;immune activation;Immunologic Markers;improved;Incidence;Inflammation;Inflammatory;inflammatory marker;innovation;Institution;Knowledge;Laboratories;Lead;Leadership;men;men who have sex with men;Mental Depression;Mentors;Mentorship;Minority;Minority Men;Names;Natural History;Neurocognitive;Neurocognitive Deficit;oral microbiome;Outcome;outreach;Pathogenesis;Pathway interactions;Phenotype;Pilot Projects;Plasma;programs;Prospective, cohort study;protocol development;Protocols documentation;psychosocial;Psychosocial Factor;Public Health;racial minority;recruit;Research;research and development;Research Personnel;research study;resilience;Risk;Role;sample collection;Science;Sex Differences;Site;social stigma;Specimen;stimulant use;substance use;Surveys;syndemic;Testing;The Multicenter AIDS Cohort Study;Tobacco;United States;Visit;Woman;Women's Interagency HIV Study

PROJECT_TITLE: MACS/WIHS -CCS


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Substance Misuse

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PI_NAMEs: DING, WEN-XING  (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Acetaldehyde;Acids;activating transcription factor;Acute;Alcohol abuse;Alcohol consumption;Alcoholic Liver Diseases;Alcohols;aldehyde dehydrogenases;Attenuated;Autophagocytosis;Biogenesis;Catabolic Process;Cells;Cessation of life;Chronic;chronic alcohol ingestion;chronic liver disease;Cirrhosis;Consumption;Data;Development;Ethanol;Ethanol Metabolism;fatty acid oxidation;Fatty Liver;feeding;Fibrosis;FRAP1 gene;gain of function;Genes;Genetic;Genetic Transcription;Goals;Guanosine Triphosphate Phosphohydrolases;Hepatic;Hepatocyte;High Fat Diet;Human;Hydrolase;Impairment;improved;Inflammation;Instruction;Intervention;knock-down;Knock-in Mouse;Knock-out;Knockout Mice;Liver;liver inflammation;liver injury;loss of function;Lysosomes;Malignant neoplasm of liver;Mediating;Mitochondria;Modeling;Molecular;Monitor;Morbidity - disease rate;mortality;mouse model;Mus;novel;novel therapeutic intervention;Nuclear Translocation;Organelles;Outcome;overexpression;Pathogenesis;Pattern;pharmacologic;Phosphorylation;PPAR gamma;Prevention;Principal Investigator;problem drinker;programs;protective pathway;Proteins;Protocols documentation;Publishing;Recovery;response;Role;Signal Transduction;Stress;targeted treatment;Testing;Therapeutic Intervention;transcription factor;Transcriptional Activation

PROJECT_TITLE: Mechanisms regulating autophagy in alcohol-induced liver injury

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AR

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Lung;Pulmonary Fibrosis;Rheumatoid Arthritis

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative: Rheumatoid arthritis (RA) is a systemic inflammatory disorder affecting approximately 3 million adults in the United States; interstitial lung disease (ILD), particularly pulmonary fibrosis, is the most common lung complication of RA and is associated with increased mortality. This study aims to define how syndecan-2 (SDC2), an antifibrotic proteoglycan, affects the development of lung fibrosis in the setting of arthritis. The results of this work will provide a better understanding of the molecular mechanisms driving the pathogenesis of RA-associated lung fibrosis and identify potential therapeutic targets to treat patients with this progressive disease.

PI_NAMEs: TSOYI, KONSTANTIN  (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Adult;Affect;age related;alveolar epithelium;Animal Model;Antibodies;Apoptosis;Area;Arthritis;Attenuated;Autoimmune;Automobile Driving;Binding;Binding Proteins;Biological;Biology;Bleomycin;bone;career;career development;Cartilage;Cell Proliferation;Cell surface;citrullinated protein;Collagen;collagen antibody induced arthritis;Complication;Data;Development;Disease;Environment;Epithelial Cells;Experimental Models;Extracellular Matrix;Family;Fibroblasts;fibroglycan;fibrotic lung disease;Functional disorder;Funding;Future;Goals;Heparan Sulfate Proteoglycan;Hospitals;Human;immune activation;Immunology;In Vitro;in vivo;Inflammatory;Inflammatory Arthritis;Interstitial Lung Diseases;joint destruction;Knowledge;Lung;lung development;Lung Diseases;Mediating;medical schools;Medicine;meetings;member;Membrane;Mentors;Mentorship;Modeling;Molecular;Molecular Biology;mortality;mouse model;Mus;Myofibroblast;overexpression;Pathogenesis;Patients;Persons;Pharmacology;Phenotype;Phosphoric Monoester Hydrolases;PIK3CG gene;Play;post-doctoral training;Predisposition;Process;Production;Progressive Disease;Property;protein activation;Protein Tyrosine Phosphatase;Protein-arginine deiminase;Proteins;Proteoglycan;PTPRJ gene;Pulmonary Fibrosis;Radiation;Recombinants;Regulation;Reporting;Research;Research Personnel;Resources;Rheumatoid Arthritis;Role;Scholarship;Scientist;Self Direction;Signal Transduction;Structure of parenchyma of lung;success;Testing;TGFB1 gene;Therapeutic;Therapeutic Intervention;therapeutic target;Time;Training;training opportunity;Translational Research;United States;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: Antifibrotic effects of Syndecan-2 and CD148 in Rheumatoid Arthritis Interstitial Lung Disease

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Microbiome;Nutrition;Obesity;Prevention

ORG_CITY: FARGO

ORG_NAME: SANFORD RESEARCH NORTH

ORG_STATE: ND

PHR: PROJECT NARRATIVE The proposed project will elucidate psychological and biological variables, including stress, reward, cortisol, and the gut microbiome, that impact the day-to-day pattern of problematic eating behavior among individuals with overweight and obesity. The knowledge gained from this study will directly inform both prevention and intervention targeting problematic eating behavior that may ultimately contribute to obesity.

PI_NAMEs: ENGEL, SCOTT G (contact);STEFFEN, KRISTINE JAYNE;WONDERLICH, STEPHEN ARTHUR

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Affect;American;Behavior assessment;Behavioral;Binge Eating;biobehavior;Biological;Biological Factors;Body Weight decreased;Brain;Calories;Carbohydrates;Complex;Consumption;Data;Data Collection;Data Reporting;dietary;Dietary intake;Eating;Eating Behavior;Economics;Energy Intake;Exhibits;experience;Fatty acid glycerol esters;Feeding behaviors;Food;food consumption;Food Selections;Genes;gut microbiome;gut microbiota;Health;high reward;Human;Hydrocortisone;indexing;Individual;Intake;Intervention;Investigation;Knowledge;Laboratories;Link;Mental Health;Methodology;Methods;microbiome;microbiota;microbiota composition;Modeling;Negative Reinforcements;novel;obese person;Obesity;Obesity Epidemic;obesity prevention;Overweight;Participant;Patient Self-Report;Pattern;perceived stress;personalized medicine;physical conditioning;Physiological;Population;prevent;Prevention;Process;prospective;psychologic;psychological stressor;Quality of life;Research;response;Rewards;Risk;Role;Stress;stress reactivity;stressor;Techniques;Testing;therapy development;Time;trait;United States;Weight Gain

PROJECT_TITLE: Biobehavioral Factors and their Impact on Stress-Related Eating in Obesity

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: Project Narrative This project investigates a class of electrode array that may be used to stimulate or record neural activity in the brain. These new devices are inserted in a less-invasive, compact form and then deploy very small electrodes to record activity of a volume of brain. These arrays will enable new neuroscience experiments that enhance our understanding of the brain and may inform future clinical devices.

PI_NAMEs: WARE, TAYLOR H (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TITLE: Deploying Intracortical Electrode Arrays to Record and Stimulate in a Tissue Volume

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Epilepsy;Health Services;Neurodegenerative;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: PEDIATRICS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: NARRATIVE (3 sentences)  To optimize care for neonatal seizures and their consequences, we propose to use observational methods to study (1) the best second-line anti-seizure medication for acute neonatal seizures (phenytoin/fosphenytoin vs levetiracetam), (2) the potential for subsequent chronic use of sodium channel blockers (i.e., oxcarbazepine) to increase the risk for infantile spasms syndrome, and (3) the reliability and validity of our published model to predict epilepsy among neonates with acute symptomatic seizures who survive into infancy. We will conduct this work using the Pediatric Epilepsy Learning Health System, a consortium of US academic pediatric epilepsy programs that work collaboratively to improve outcomes for children with epilepsy through cycles of electronic health record collection and analysis. The proposal aligns with the 2020 Epilepsy Research Benchmarks and will directly inform clinical care for neonates with acute symptomatic seizures, as well as lay the foundation for epilepsy prevention trials.

PI_NAMEs: GRINSPAN, ZACHARY MICHAEL (contact)

PROGRAM_OFFICER_NAME: HARTMAN, ADAM L

PROJECT_TERMS: Accounting;acquired epilepsy;Acute;Acute Brain Injuries;Address;Age;Anticonvulsants;Benchmarking;Biological Markers;Brain Stem;Caring;Case Study;Cerebral Palsy;Child;childhood epilepsy;Chronic;Clinical;clinical care;Clinical Management;Collaborations;Collection;comparative effectiveness;comparative effectiveness study;compare effectiveness;Data;Development;Effectiveness;Electroencephalography;Electronic Health Record;electronic structure;Enrollment;Epilepsy;Epileptogenesis;Evolution;fosphenytoin;Foundations;Goals;hazard;Health system;high risk;high risk population;Hour;Human;improved outcome;infancy;Infant;Infantile spasms;Injury;Intellectual functioning disability;Intervention;Learning;Levetiracetam;Life;Live Birth;Magnetic Resonance Imaging;Methods;Modeling;Modernization;Mus;neonatal care;Neonatal Intensive Care Units;neonatal seizure;neonate;Neurosciences Research;Observational Study;Outcome;oxcarbazepine;peace;Phenobarbital;Phenytoin;Predictive Value;prevent;preventable epilepsy;Prevention trial;programs;Publishing;Recommendation;Recording of previous events;Research;Research Design;Research Personnel;Risk;Risk Reduction;Safety;Sample Size;Seizures;Selection Bias;Selection for Treatments;Site;Sodium Channel;Sodium Channel Blockers;Spasm;Statistical Data Interpretation;Survivors;Syndrome;Techniques;Tetrodotoxin;Tuberous Sclerosis;Validity and Reliability;Variant;Vigabatrin;voltage;Vulnerable Populations;Work

PROJECT_TITLE: NS-PEACE Neonatal Seizures -Predicting Epilepsy and Assessing Comparative Effectiveness.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-F(02)M]


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cancer;Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lung;Mental Health;Neurosciences;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE This application proposes to establish The University of North Carolina at Chapel Hill as a Clinical Research Site (CRS) for the Multicenter AIDS Cohort Study (MACS)/Women’s Interagency HIV Study (WIHS) Combined Cohort Study (MACS/WIHS-CCS). We propose to rapidly establish the UNC MACS/WIHS-CCS CRS, contribute meaningfully to the MACS/WIHS-CCS Unified Science Agenda, and undertake ambitious research that encompasses pulmonary, cardiovascular, neurocognitive, and other HIV-related comorbidities; HIV pathogenesis/cure; social epidemiology and health outcomes; behavioral research; and advanced epidemiologic methods. By contributing a representative population of men and women, innovative science, and a strong, multidisciplinary cadre of investigators, UNC will enhance the efforts of the MACS/WIHS-CCS, expand the range of questions that can be addressed and, in collaboration with the entire group, improve the health of men and women with or at high risk for HIV infection.

PI_NAMEs: DRUMMOND, MICHAEL BRADLEY;FLORIS-MOORE, MICHELLE  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affect;Aging;AIDS clinical trial group;American;antiretroviral therapy;Area;Behavioral Research;Biological Markers;Blood;Cardiovascular Diseases;Cardiovascular system;career;Characteristics;Chronic;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Clinical;clinical research site;cohort;Cohort Studies;Collaborations;collaboratory;Communicable Diseases;comorbidity;Comprehensive Cancer Center;Consent;Data Analyses;design;Disease;Disease remission;effective intervention;Enrollment;Epidemic;Epidemiologic Methods;Ethnic Origin;Female;Funding;gender difference;Geography;Gills;global health;Grant;Guidelines;Health;health disparity;Health Policy;Health Services Research;high risk;high risk population;HIV;HIV Infections;HIV prevention trials network;HIV Seropositivity;improved;Incidence;Individual;Inequity;Infection;Infrastructure;innovation;Insurance Coverage;interest;Interruption;Intervention;Lead;Leadership;Link;Lung;male;male health;Malignant neoplasm of lung;Malignant Neoplasms;men;Methods;mortality;multidisciplinary;Myocardial Infarction;Nature;Neighborhoods;Neurocognitive;North Carolina;novel;Outcome;outcome disparities;Participant;participant enrollment;Pathogenesis;Persons;Pharmacy Schools;Plasma;Population;Prevention;programs;Public Health;Publications;pulmonary function;pulmonary function decline;Race;Research;Research Personnel;research study;Respiratory Signs and Symptoms;Risk;Risk Factors;Schools;Science;sex;Sex Differences;Site;social epidemiology;Socioeconomic Status;Stroke;structural determinants;System;The Multicenter AIDS Cohort Study;Tissue Procurements;Tissues;Universities;Viral Load result;Viral reservoir;Virus Latency;Woman;Women's Interagency HIV Study

PROJECT_TITLE: UNC MACS/WIHS Combined Cohort Study Clinical Research Site


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Prevention;Sleep Research;Substance Misuse

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Narrative This application is for renewal for 7 years of the Baltimore-Washington DC site of the Multicenter AIDS Cohort Study (MACS), a longstanding study of the natural and treated histories of HIV infection men who have sex with men in four US cites (Baltimore-Washington, Los Angeles, Pittsburgh, Chicago) which has made many important contributions to the treatment and understanding of HIV infection since 1984. For the next 7 years, we propose to integrate our site with the 9 WIHS sites into a new MACS-WIHS Combined Cohort Study (CCS) which will follow men already enrolled in Baltimore and Washington, DC, and also recruit a few new men replacing those who have been lost to the study, in order to better understand the long-term consequences of living with HIV, including possible effects on chronic diseases and aging, and to improve our understanding of the mechanisms of these consequences.

PI_NAMEs: BROWN, TODD T;MARGOLICK, JOSEPH B. (contact)

PROJECT_TERMS: Achievement;Acquired Immunodeficiency Syndrome;actigraphy;adjudication;Affect;Age;Aging;aging related;Ancillary Study;antiretroviral therapy;Area;Artificial Intelligence;Baltimore;Behavioral;Biological;Biological Specimen Banks;Cardiovascular Diseases;Cardiovascular system;career development;Caring;Chicago;Chronic Disease;Clinic;clinical care;clinical research site;cohort;Cohort Studies;comorbidity;Cryopreservation;Data;data management;Diabetes Mellitus;Disease;District of Columbia;Echocardiography;Endocrine;Enrollment;Epidemic;Equilibrium;Event;experience;follow-up;Follow-Up Studies;Funding;Goals;Grant;Health;Health behavior;health disparity;high standard;HIV;HIV Infections;Home;Hospitals;Impaired cognition;improved;Inflammation;innovation;Laboratories;Lead;Leadership;Liver diseases;Long-Term Care;Los Angeles;Lung;Machine Learning;Malignant Neoplasms;Measurement;Medicine;men;men who have sex with men;Metabolic;Metabolic Diseases;Methods;National Heart, Lung, and Blood Institute;Natural History;Neurocognitive;neurocognitive disorder;Participant;Pathogenesis;Performance;Peripheral Blood Mononuclear Cell;Persons;Physical activity;Plasma;Play;Polysomnography;Principal Investigator;Productivity;Protocols documentation;psychosocial;Publications;Questionnaires;Reading;Recording of previous events;recruit;repository;Research;Research Personnel;response;Risk Factors;RNA;Role;Science;Serum;Site;Sleep;Specimen;synergism;T-Lymphocyte Subsets;Techniques;The Multicenter AIDS Cohort Study;Time;Viral load measurement;Washington;Woman;Women's Interagency HIV Study;Work

PROJECT_TITLE: Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Mental Health;Neurosciences;Precision Medicine;Prevention;Substance Misuse

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: The NC CRS is part of the longest-running prospective study of the natural and treated history of HIV infection in people at risk for becoming infected. This ongoing study chronicles biological and psychosocial factors that have shaped the epidemic, tracking HIV disease and HIV-related comorbidities. The knowledge gained regarding effects of the virus and aging on inflammation and immune dysfunction, which render some people more susceptible to HIV-related comorbidities than others, will improve the clinical care of people living with HIV/AIDS, guide public health public health policy, facilitate discovery of novel drug targets, and contribute to vaccine development.

PI_NAMEs: PALELLA, FRANK J;STOSOR, VALENTINA ;WOLINSKY, STEVEN M (contact)

PROJECT_TERMS: Acceleration;Active Sites;Address;adjudication;Advocacy;Aging;Agreement;Basic Science;Behavior;Big Data;Biological Assay;Biological Factors;Biological Markers;Biological Process;Biology;Blood;Blood specimen;Catalogs;Cells;Chronic;Clinical;clinical care;Clinical Research;clinical research site;co-infection;cohort;Cohort Studies;Collaborations;Collection;Communities;comorbidity;Complex;cooking;County;Data;Data Analyses;Data Collection;data integration;Data Set;Development;Diagnosis;Disease;disease model;Disease Outcome;Enrollment;Ensure;Epidemic;epidemiology study;Event;flexibility;follow-up;functional genomics;Funding;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Determinism;Genetic Risk;genetic variant;Genome;Genotype;Goals;good laboratory practice;Health;Health Insurance Portability and Accountability Act;Health Policy;Healthcare;Heritability;HIV;HIV Infections;HIV/AIDS;Hospitals;Human;Image;immune activation;Immune response;Immune System Diseases;improved;inclusion criteria;Infection;Inflammation;Inflammation Mediators;Inflammatory;Information Technology;Informed Consent;Infrastructure;innovation;insight;Interdisciplinary Study;Knowledge;Laboratories;Leadership;Link;Maintenance;Measures;Medical Records;microbiome;Modeling;Modeling of Functional Interactions;Molecular Profiling;multidisciplinary;new therapeutic target;next generation;novel;Office of Administrative Management;Outcome;Participant;participant enrollment;participant retention;Pathogenicity;Pathway interactions;patient engagement;Pattern;Persons;Pharmaceutical Preparations;Phenotype;Policies;Policy Developments;Populations at Risk;Practice Guidelines;Precision Medicine Initiative;predictive modeling;Predisposition;Procedures;Production;Productivity;programs;Property;Prospective Studies;protein expression;protein protein interaction;Protocols documentation;Psychosocial Factor;Public Health;quality assurance;Quality Control;Recording of previous events;Reporting;repository;Reproducibility;Research;Research Priority;Research Project Grants;resilience;Resources;response;Risk;risk variant;Running;sample collection;Science;Scientific Advances and Accomplishments;Scientist;Severity of illness;Shapes;Signal Pathway;Signaling Protein;social science research;System;Testing;Tissues;Training;United States National Institutes of Health;Universities;vaccine development;Variant;Virus;virus host interaction;Virus Replication;Work

PROJECT_TITLE: Northwestern CORE Clinical Research Site: Trans-omics for HIV/AIDS Research


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Mental Health;Mental Illness;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative The goal of this project is to test whether a novel behavioral activation/problem solving based counseling intervention results in higher rates of smoking cessation than standard behavioral counseling among HIV+ smokers in Botswana. It will also assess whether changes in hypothesized mediators (depressive symptoms, use of substitute reinforcers and avoidance of complementary reinforcers of smoking behavior and problem solving skill) are the mechanisms behind successful quitting.

PI_NAMEs: GROSS, ROBERT  (contact);SCHNOLL, ROBERT ADAM

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: Abstinence;Address;Adult;Africa;Africa South of the Sahara;African;antiretroviral therapy;Anxiety;Behavior;behavior change;Behavior Therapy;Behavioral;behavioral economics;Botswana;care delivery;Caring;Chronic Obstructive Pulmonary Disease;clinical infrastructure;common symptom;comorbidity;cost;Counseling;Country;Data;Decentralization;depressive symptoms;design;Developing Countries;efficacy evaluation;Epidemic;Evidence based practice;experience;General Population;Goals;Health;health care availability;health care delivery;high risk;HIV;HIV Infections;HIV/AIDS;Income;Individual;Infrastructure;Intervention;intervention effect;low and middle-income countries;Mediating;Mediator;medication compliance;Mental Depression;mobile computing;Modeling;Morbidity - disease rate;mortality;Motivation;Myocardial Infarction;negative affect;Nicotine Dependence;nicotine replacement;novel;Outcome;Pathway interactions;Pattern;Persons;Pharmacotherapy;Pilot Projects;pilot test;Population;primary outcome;Problem Solving;problem solving therapy;Professional counselor;programs;psychological distress;psychological symptom;Public Health;Randomized;randomized trial;reduce tobacco use;reinforcer;relapse risk;Research;Rewards;Risk;Role;Sampling;scale up;Site;skills;Smoker;Smoking;Smoking Behavior;smoking cessation;Smoking Cessation Intervention;Telephone;Testing;Tobacco Dependence;Tobacco smoking behavior;Tobacco use;Tobacco Use Cessation;trial comparing;trial design;Tuberculosis;varenicline;virtual;Withdrawal;working group;years of life lost

PROJECT_TITLE: Testing the Combination of Behavioral Activation and Problem Solving as a Novel Behavioral Smoking Cessation Intervention for Smokers with HIV in Botswana


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Precision Medicine;Prevention;Social Determinants of Health;Substance Misuse;Underage Drinking;Violence Research

ORG_CITY: ANN ARBOR

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Risky drinking behavior (i.e., episodic binge and high-intensity drinking), which peaks in young adulthood, is estimated to account for more than 40,000 deaths annually and over $167 Billion in economic costs in the United States. Young adult risky drinkers are a heterogeneous group, which makes them very difficult to study and to predict who will go on to develop lasting problems with alcohol use and alcohol use disorder. This research will implement cutting-edge machine learning techniques, and apply them to data collected from daily surveys and passive smartphone sensors in young adult risky drinkers to develop personalized models of problematic alcohol use.

PI_NAMEs: WRIGHT, AIDAN GREGORY CRAVER (contact)

PROGRAM_OFFICER_NAME: ZHA, WENXING

PROJECT_TERMS: Acute;adaptive intervention;Address;Affect;Alcohol abuse;alcohol behavior;Alcohol consumption;alcohol related consequences;alcohol research;alcohol use disorder;Alcohols;Behavior;Behavior Control;Behavioral;Behavioral Model;bench to bedside;Bluetooth;Cellular Phone;Cessation of life;Clinical;Communities;Complex;craving;Cross-Sectional Studies;Dangerousness;Data;Data Analytics;Data Collection;deep learning;Detection;Development;Diagnosis;drinking;drinking behavior;Ecological momentary assessment;economic cost;Economics;emotion regulation;Emotional;Enrollment;Environment;falls;Female;follow-up;Foundations;Future;Gender;Group Meetings;Harm Reduction;Health;Heavy Drinking;high intensity drinking;high risk drinking;Hour;improved;in vivo;Individual;Individuality;innovation;Intervention;Knowledge;learning network;Life;Location;longitudinal analysis;Machine Learning;machine learning algorithm;male;Measurement;Measures;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;Motivation;multitask;National Institute on Alcohol Abuse and Alcoholism;neural network;novel;novel strategies;Outcome;Participant;Patient Self-Report;Pattern;personalized medicine;personalized predictions;Persons;positive emotional state;Predictive Factor;predictive modeling;Prevalence;prevent;Process;prospective;Protocols documentation;psychologic;Psychological Models;psychosocial;Public Health;real time monitoring;recruit;Research;Research Design;Research Personnel;Risk;Risk Factors;Sampling;Science;sensor;Series;smartphone based assessment;social;Social Environment;social group;Statistical Methods;Strategic Planning;Surveys;Symptoms;System;Techniques;Technology;Telephone;Testing;Time;Translating;United States;Vehicle crash;Violence;working group;young adult

PROJECT_TITLE: Using Smartphone Assessments for Personalized Prediction of Problematic Alcohol Use


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Gene Therapy;Genetics;Hepatitis;Liver Disease;Precision Medicine;Prevention

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: PROJECT NARRATIVE NAFLD/NASH is the most common chronic liver disease with a heavy social burden but no effective drug treatment at present. Our project for the first time aims at developing a personalized genetic medicine for NAFLD/NASH, which has a great impact on both improving the human health and reducing social burden. We use a novel and unprecedented approach in this project, which has a great potential to establish a new paradigm for drug develop for other common diseases.

PI_NAMEs: LIU, WANQING  (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Acetylgalactosamine;Alcoholic Liver Diseases;Alleles;Automobile Driving;Binding;Biological Assay;chronic liver disease;Classification;Clinical;comorbidity;comparative efficacy;Data;design;Development;Disease;disease phenotype;disorder subtype;DNA Sequence Alteration;Dominant-Negative Mutation;Down-Regulation;Drug Delivery Systems;drug development;effective therapy;efficacy evaluation;Fatty Liver;FDA approved;Fibrosis;first-in-human;Gene Deletion;Genes;Genetic;Genetic Medicine;genetic risk factor;Genetic Transcription;genome wide association study;Goals;Health;Hepatic;hepatic lipase;Histology;Human;human disease;humanized mouse;Hydrolase;Hypertriglyceridemia;improved;In Vitro;in vivo;Inflammation;Investigational Drugs;knock-down;Lead;Legal patent;Lipids;Lipolysis;Liver;Liver diseases;Mediating;Medicine;Messenger RNA;Metabolic;Modeling;Modification;mouse model;mutant;Mutation;Names;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel strategies;oligonucleotide therapeutics;Oligonucleotides;overexpression;Patients;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Pharmacotherapy;Phenotype;Phospholipase;pre-clinical;precision genetics;Precision therapeutics;preclinical evaluation;Prevention;Property;Protein Isoforms;Proteins;prototype;RNA delivery;RNA Interference;Role;Safety;screening;Series;Small Interfering RNA;social;Specificity;success;targeted treatment;Testing;Therapeutic;Therapeutic Agents;therapeutic candidate;therapeutic target;Time;tool;Toxic effect;Toxicokinetics;Translations;treatment strategy;Triglycerides;Variant

PROJECT_TITLE: A Precision Targeted Therapeutics for Nonalcoholic Fatty Liver Disease

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cocaine;Drug Abuse (NIDA only);Genetics;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: BIRMINGHAM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Drugs of abuse activate specific cell populations within brain reward circuits, but it is not clear what molecular mechanisms regulate this process or how drug experience can result in long-lasting changes within these cells. This proposal will examine the role of Reelin, a large extracellular protein, in regulation of the molecular and genetic mechanisms that contribute to cellular and behavioral responses to cocaine. This research will contribute fundamental knowledge to our understanding of how brain circuits drive motivated behaviors in the context of substance abuse disorders, and has the potential to identify novel cellular targets for addiction therapeutics.

PI_NAMEs: DAY, JEREMY J (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: addiction;Affect;Association Learning;Atlases;Behavior;Behavioral;Behavioral Assay;behavioral plasticity;behavioral response;Binding;Biological Models;Brain;Brain region;Cells;cellular targeting;Clustered Regularly Interspaced Short Palindromic Repeats;Cocaine;cocaine receptor;Code;Corpus striatum structure;Custom;Data;Disease;Dopamine;Dopamine Receptor;drug action;drug maintenance;drug of abuse;Economics;Electrophysiology (science);Epigenetic Process;Exhibits;experience;experimental study;extracellular;Extracellular Matrix Proteins;Extracellular Protein;Future;Genes;Genetic;Genetic Transcription;Genome;Human;Immediate-Early Genes;Impairment;In Vitro;in vivo;Individual;insight;knock-down;knockout animal;Knowledge;Learning;Link;Low Density Lipoprotein Receptor;Memory;Messenger RNA;Molecular;motivated behavior;Motor;multi-electrode arrays;N-Methyl-D-Aspartate Receptors;neuronal excitability;Neuronal Plasticity;Neurons;neurotransmission;novel;Nucleus Accumbens;overdose death;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Physiological;Physiology;Play;Population;preference;Preparation;Process;programs;Property;psychostimulant;Public Health;Rattus;receptor;Receptor Activation;receptor function;reelin protein;Regulation;Research;Resolution;response;Rewards;Role;Self Administration;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;Slice;social;Stimulant;stimulant abuse;Structure;Substance abuse problem;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;System;Testing;Therapeutic;tool;Transcriptional Regulation;United States;Work

PROJECT_TITLE: Reelin Signaling and Function in Cocaine Response

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Neurodegenerative;Rare Diseases

PHR: PROJECT NARRATIVE  Wilson’s disease is an autosomal recessive disorder resulting from mutations in the copper transporter, Atp7b. Patients with Wilson’s disease develop toxic levels of copper primarily in the liver and brain. We aim to study the effect of manipulation of hepatic and intestine nuclear receptors in Atp7b-/- mice.

PI_NAMEs: WOOTON-KEE, CLAVIA RUTH (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Acceleration;Agonist;Amino Acids;Antibiotics;ATP phosphohydrolase;Attenuated;autosome;Bile Acid Biosynthesis Pathway;Bile Acids;Binding;Biological Assay;biomarker identification;blood glucose regulation;Brain;Cell Cycle Regulation;Cell Proliferation;cell regeneration;chelation;ChIP-seq;Cholestasis;chronic liver disease;Cirrhosis;Citric Acid Cycle;clinical heterogeneity;clinically relevant;Copper;Data;Defect;Depressed mood;Development;Diagnosis;Disease;Exhibits;Feedback;Fibrosis;Functional disorder;Gene Expression;Genes;glucose metabolism;Growth;Hepatic;Hepatocyte;Hepatolenticular Degeneration;Human;Impairment;improved;Infection;Inflammation;Intestinal Diseases;Intestines;Knockout Mice;Link;Liver;Liver diseases;Liver Dysfunction;Liver Failure;Liver Regeneration;liver transplantation;Measures;Metabolic;metabolic profile;Metabolism;metabolomics;mitochondrial dysfunction;Molecular;Molecular Profiling;Molecular Target;mRNA Expression;Mus;Mutation;National Institute of Diabetes and Digestive and Kidney Diseases;Natural regeneration;new therapeutic target;Nodule;novel strategies;Nuclear Receptors;Organoids;Oxidative Stress;Partial Hepatectomy;Pathology;Patients;Pharmaceutical Preparations;Phenotype;pleiotropism;Primary carcinoma of the liver cells;programs;Proliferating;Quality of life;Regulation;Reporting;response;Response Elements;rifaximin;Role;Serum;Severity of illness;side effect;Signal Pathway;Signal Transduction;Supplementation;Symptoms;Testing;therapeutic target;Toxic effect;transcriptome;transcriptome sequencing;transcriptomics;Zinc

PROJECT_TITLE: Nuclear Receptor Dysfunction Reprograms Metabolism and Cellular Proliferation in Wilson's Disease


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE Dysregulation of inhibitory signaling is implicated in a wide array of neurological disorders and diseases, including those with cognitive and/or affective components. The goal of this project is to investigate the role of a family of modular regulatory complexes and related factors that shape the strength, sensitivity, and temporal precision of a prevalent form of inhibitory signaling in neurons. Successful completion of this project will yield new insights that could be leveraged to develop novel therapeutic approaches for neurological problems characterized by aberrant inhibitory signaling.

PI_NAMEs: MARTEMYANOV, KIRILL A.;WICKMAN, KEVIN D (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Ablation;Adaptor Signaling Protein;Adenylate Cyclase;Affect;Affective;Aminobutyric Acids;Architecture;assay development;Behavior;Binding;Biochemical;Biological Assay;Brain;Cells;Cognition;Cognitive;Collaborations;Complex;convict;Coupling;Custom;Data;Dedications;design;Disease;Electrophysiology (science);Elements;Ensure;Enzymes;Epilepsy;Family;G-Protein-Coupled Receptors;gain of function;gamma-Aminobutyric Acid;Genetic;genetic manipulation;Goals;GTP-Binding Protein Regulators;GTP-Binding Proteins;hippocampal pyramidal neuron;Hippocampus;innovation;insight;Interdisciplinary Study;Investments;Ion Channel;Knowledge;loss of function;Mediating;member;Modeling;Molecular;multidisciplinary;Mus;Negative Finding;Nervous System Disorder;Neurologic;Neurons;Neurotransmitters;novel;novel therapeutic intervention;Optical reporter;Optics;Orphan;palmitoylation;Play;predictive modeling;programs;Protein Family;Proteins;receptor;Receptor Signaling;reconstitution;Regulation;Research Proposals;Resolution;RGS Proteins;Role;Route;Shapes;Signal Pathway;Signal Transduction;Signaling Protein;Structure;Synaptic plasticity;Testing;Therapeutic Intervention;Time;tool;tool development;Work

PROJECT_TITLE: Architecture of inhibitory G protein signaling in the hippocampus

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Orphan Drug;Precision Medicine;Prostate Cancer;Rare Diseases;Urologic Diseases

PHR: PROJECT NARRATIVE Prostate cancer is a leading cause of cancer morbidity and mortality in the United States. Pathway activation of signaling proteins is hypothesized to be a crucial step in the progression of prostate cancer toward a lethal variant of prostate cancer that lacks androgen receptor signaling known as neuroendocrine prostate cancer (NEPC). The proposed research will aim to identify RET transcriptional regulation and implicate RET tyrosine kinase signaling as a key therapeutic target for NEPC with the goal to reduce morbidity and mortality associated with lethal NEPC.

PI_NAMEs: DRAKE, JUSTIN MICHAEL (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: abiraterone;Adenocarcinoma;American;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Androgens;antagonist;ASCL1 gene;Binding;Binding Sites;Biological Models;Cancer Etiology;Carcinoma;cell growth;Cell Line;Cell Survival;Cessation of life;chemotherapy;ChIP-seq;Classification;Clinical;Clinical Trials;Combined Modality Therapy;Data;Data Set;design;Development;Disease;Drug Targeting;Enhancers;enzalutamide;FDA approved;Gene Expression;Genes;genetic manipulation;Genetic Transcription;Goals;Gonadotropin Hormone Releasing Hormone;Hormones;Human;Human Cell Line;improved;In Vitro;in vivo;ineffective therapies;inhibitor;inhibitor therapy;insight;Institution;kinase inhibitor;knock-down;Ligands;Malignant neoplasm of prostate;Malignant Neoplasms;Manuscripts;Mediating;men;Messenger RNA;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Mutation;Neoplasm Metastasis;neural;Neuroendocrine Prostate Cancer;Neuroendocrine Therapy;Neuronal Differentiation;Neurosecretory Systems;novel;novel therapeutics;optimal treatments;Organoids;Outcome;overexpression;Papillary thyroid carcinoma;Pathway interactions;patient derived xenograft model;patient stratification;Patients;pharmacodynamic biomarker;phosphoproteomics;Phosphorylation;Phosphotransferases;Platinum;predictive signature;Proliferating;promoter;prostate cancer cell;prostate cancer cell line;prostate cancer model;prostate cancer progression;Prostate Cancer therapy;protein expression;Protein Tyrosine Kinase;Proteins;proto-oncogene protein c-ret;Proto-Oncogene Proteins c-akt;Publishing;Receptor Signaling;Regulation;Regulatory Element;Research;Resistance;responders and non-responders;response;RET gene;RET inhibition;Sampling;Signal Pathway;Signal Transduction;Signaling Protein;small cell lung carcinoma;standard of care;targeted treatment;taxane;Testing;Therapeutic;therapeutic target;therapy resistant;transcription factor;Transcriptional Regulation;treatment responders;tumor;Tumor Cell Line;tumor growth;tumor xenograft;United States;Up-Regulation;Variant;Western Blotting;Work

PROJECT_TITLE: RET Regulation and Targeting in Neuroendocrine Prostate Cancer

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Neurosciences;Opioids;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: OMAHA

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project narrative As a proof-of-concept studies, the current proposal using a preclinical model aims to decode the role of brain derived extracellular vesicles (BDEVs), their molecular mechanisms and identifying novel biomarkers in a subset of vulnerable individuals: HIV+ adolescents. These studies will further inform us to possibly translate these findings for preventive intervention, reduce disease risk and promote well-being in this vulnerable population.

PI_NAMEs: PENDYALA, GURUDUTT  (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: addiction;Address;Adolescence;Adult;Animal Model;Animals;Anti-Inflammatory Agents;Architecture;Attitude;Behavior;Behavioral;Biogenesis;Biological Markers;Brain;bullying;Catecholamines;Cell Physiology;Cells;Cognitive;Collaborations;confocal imaging;Coupled;critical developmental period;Data;Dendritic Spines;Development;Disease;disorder risk;Drug Delivery Systems;emerging adult;Emotional;experience;Exposure to;extracellular vesicles;Functional disorder;Funding Mechanisms;Future;Glean;Glutamate Receptor;Glutamate Transporter;Glutamates;Goals;HIV;HIV Infections;HIV-infected adolescents;Human;improved;Incidence;Individual;Inflammation;Injury;intravenous drug use;Knowledge;Lead;Lipids;Literature;Measures;Mental disorders;Molecular;nanocarrier;nanoplasmonic;neural;Neurological outcome;Neurons;next generation;novel;novel marker;novel therapeutics;opioid use;Outcome;Oxycodone;Pathway interactions;Personal Satisfaction;Pharmaceutical Preparations;Phase;Plasma;Pre-Clinical Model;Prejudice;prescription opioid;preventive intervention;protein biomarkers;Proteins;Proteomics;Psychopathology;Psychosocial Stress;Rat Transgene;Rattus;Reporting;Research;Research Personnel;Risk;Role;Self Administration;Severities;social;social defeat;Social Development;social stigma;social stress;social vulnerability;Societies;Stress;Substance abuse problem;Synapses;synaptic function;Testing;Therapeutic;Tissues;Translating;treatment group;Untranslated RNA;Validation;Vulnerable Populations;Work

PROJECT_TITLE: Mechanisms underlying prescription opioid use post social defeat in HIV+ adolescents

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Nutrition

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE GH and IGF-1 act on peripheral tissues to importantly influence growth, metabolism and body composition across the human lifespan. In GH disorders, these are substantially altered. Central effects of GH may also affect these processes. This project utilizes human models, healthy subjects and GH deficient patients administered GH, to investigate the GH-AgRP axis, which we hypothesize is a key mechanism of GH’s nutritional and metabolic effects. We study the potential role of GH-stimulated AgRP in GH-induced metabolic abnormalities and a potential therapy for them. This project will provide valuable insights into the role of AgRP and the GH- AgRP axis in GH disorders.

PI_NAMEs: FREDA, PAMELA U (contact)

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: Acromegaly;Affect;Agonist;antagonist;Appetite Stimulants;ART protein;Attenuated;Body Composition;Body Weight;Brain;Clinical;Clinical Treatment;Data;Development;Disease;Energy Metabolism;falls;GLP-I receptor;glucose metabolism;Growth;Homeostasis;Hormones;Human;human model;Hypothalamic structure;Impairment;Infusion procedures;innovation;insight;Insulin Resistance;Insulin-Like Growth Factor I;Investigation;Leptin;leptin receptor;Level of Evidence;life span;Link;liraglutide;Mediation;Mediator;Metabolic;Metabolism;mortality;Mus;Neurons;Neuropeptides;novel;Nutrient;nutrient deprivation;nutrition;Nutritional;Obesity;Operative Surgical Procedures;Patients;pegvisomant;Peptides;Peripheral;Pharmaceutical Preparations;Phase;Placebos;Plasma;Process;Protein Overexpression;randomized placebo controlled study;receptor;response;Rest;Role;Signal Transduction;Somatotropin;stem;Testing;Time;Tissues;Weight;Work

PROJECT_TITLE: Central Mediation of Growth Hormone Effects in Humans

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Nutrition

ORG_CITY: LOS ANGELES

ORG_NAME: MAX BIOPHARMA, INC.

PHR: RELEVANCE TO PUBLIC HEALTH The proposed studies will facilitate the therapeutic development of a novel class of oxysterol molecules that have been found to inhibit transforming growth factor-β (TGF-β), Hedgehog (Hh) and Toll-Like Receptor (TLR) signaling that are the main drivers of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Our lead compound, Oxy210, inhibits NASH as well as atherosclerosis and inflammation in white fat tissue in a humanized mouse model and has favorable pharmacokinetic and safety profiles. In proposed studies in this application, we will provide further support for the candidacy of Oxy210 for development into potentially potent orally available anti-fibrosis compounds for the treatment of NASH.

PI_NAMEs: PARHAMI, FARHAD  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Actins;Acute;Affect;Agonist;alcohol exposure;Alcoholic Fatty Liver;analog;antagonist;Anti-Inflammatory Agents;Antiinflammatory Effect;apolipoprotein E-3;Apoptosis;Atherosclerosis;Award;California;Cardiovascular Diseases;Cell Differentiation process;Cells;CETP gene;Cholesterol;Chronic;Circulation;Cirrhosis;clinically significant;COL1A1 gene;Collagen;connective tissue growth factor;culture plates;cytokine;Deposition;Development;Diabetes Mellitus;Diet;Disease;drug candidate;Drug Kinetics;efficacy evaluation;Endocrinology;Endogenous Factors;Erinaceidae;Esterification;Evaluation;Exposure to;Family;Fatty acid glycerol esters;fatty liver disease;FDA approved;Fibrosis;Future;Gene Expression;Genotype;Grant;Guidelines;Health;Hepatic;Hepatic Stellate Cell;Hepatocyte;Human;humanized mouse;Hyperlipidemia;improved;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;Inhibition of Apoptosis;inhibitor;Injury;Investigation;Kidney;kinase inhibitor;Lead;Ligands;Lipids;Liver;Liver Failure;Liver Fibrosis;liver injury;liver transplantation;Lung;Macrophage;Manuscripts;Mediating;Medical;Medicine;Metabolic;Metabolism;Molecular;Molecular Mechanisms of Action;Morbidity - disease rate;mortality;mouse model;Mus;Myofibroblast;National Institute of Diabetes and Digestive and Kidney Diseases;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel drug class;Oncology;Oral;Oral Administration;Organ;Orthopedics;pandemic disease;Pathogenesis;Pathologic;Pathology;Pathway interactions;patient population;Phase;Phenotype;Phosphorylation;Population;pre-clinical;Predisposition;Prevention;Primary carcinoma of the liver cells;Proliferating;Property;Protein-Lysine 6-Oxidase;Public Health;Publishing;Publishing Peer Reviews;Receptor Signaling;Reporting;response;Role;Safety;safety study;Series;Signal Pathway;Signal Transduction;Small Business Innovation Research Grant;small molecule;Smooth Muscle;stellate cell;Structure-Activity Relationship;Testing;TGFB1 gene;Therapeutic;therapeutic development;tissue culture;Tissues;TLR2 gene;TLR4 gene;Toll-like receptors;Toxicokinetics;Toxicology;transcriptome sequencing;Transforming Growth Factor beta;Tyrosine Kinase Receptor Inhibition;Virus Diseases;western diet;wound healing

PROJECT_TITLE: Evaluation of anti-fibrotic and anti-inflammatory semi-synthetic oxysterol, Oxy210, as a therapeutic drug candidate for non-alcoholic steatohepatitis


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Circadian desynchrony, such as in millions of shift workers, is a strong risk factor for diabetes and atherovascular disease (AVD), the leading cause of death in the United States. We and others have shown the critical function of the central and intrinsic molecular clocks in regulating cellular stress pathways, and that their disruption leads to diabetes and AVD. However, the underlying mechanisms remain poorly understood and there is no specific therapy to prevent circadian desynchrony-induced diabetes and AVD. We have assembled an interdisciplinary Multi-PI team with complementary expertise to investigate how loss of synchronization between environment, central clock and peripheral clocks leads to dysregulated cellular stress responses and cardiometabolic diseases, and test potentially translatable environmental and pharmacological protective interventions.

PI_NAMEs: FIGUEIRO, MARIANA GROSS;PAUL, ANTONIO ;YECHOOR, VIJAY K (contact)

PROGRAM_OFFICER_NAME: SILVA, CORINNE M

PROJECT_TERMS: Acceleration;Address;Agonist;Area;ARNTL gene;Arterial Fatty Streak;Atherosclerosis;Beta Cell;biological adaptation to stress;blind;blood glucose regulation;Cardiometabolic Disease;cardiometabolism;Cause of Death;Cell Physiology;cell type;Cells;Cellular biology;Cellular Stress;Chronic;circadian;circadian biology;Circadian desynchrony;Circadian Dysregulation;circadian pacemaker;comparison control;Coronary;Coupled;Darkness;Data;Diabetes Mellitus;Disease;endoplasmic reticulum stress;Enhancers;Environment;environmental change;environmental intervention;epidemiologic data;experience;Exposure to;Foam Cells;gain of function;General Population;Genes;Genetic;Genetic Models;Glucose;Glucose Intolerance;glucose metabolism;Heart Diseases;Hepatocyte;high risk population;Human;Hypothalamic structure;Immune;Indoor environment;Inflammation Mediators;Inflammatory;insight;Insulin;Insulin Resistance;insulin signaling;Intervention;Intervention Studies;Lead;Lesion;Light;light intensity;Link;lipid metabolism;Liver;Macrophage;Metabolic Diseases;Metabolic syndrome;Metabolism;Molecular;molecular clock;mouse genetics;mouse model;Mus;nobiletin;Non-Insulin-Dependent Diabetes Mellitus;Oxidative Regulation;Oxidative Stress;Pathogenesis;Pathway interactions;Patients;Pattern;Peripheral;permissiveness;pharmacologic;Phenotype;Phototherapy;Prediabetes syndrome;prevent;protective effect;response;Risk;Risk Factors;risk mitigation;Role;Rotation;Schedule;shift work;targeted treatment;Testing;Therapeutic;Tissues;Transcriptional Regulation;transcriptome sequencing;translational potential;United States;Vision;Work

PROJECT_TITLE: Clock modulation in circadian desynchrony induced diabetes and atherovascular disease - mechanisms and interventions

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Public Health Relevance Statement  Deregulation of the ERK1/2 signaling cascade is found in 30% of all tumors and multiple developmental abnormalities. While virtually every component of the cascade is target for therapeutic development, the effective targeting of this pathway in disease relies upon a clear understanding of all the intricacies in modulating numerous signaling components. The results of this study focused on the non-canonical regulators of the ERK1/2 pathway may lead to the discovery of new diagnostics as well as new treatments for diseases including Noonan-like Syndrome and some cancers.

PI_NAMEs: GALPERIN, EMILIA  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Address;Biological Markers;biophysical techniques;Cell Adhesion;cell motility;Cell Physiology;Cells;cellular transduction;Clinical;Complex;Congenital Abnormality;Development;developmental disease;Disease;Endosomes;Enzymes;Funding;Future;Genes;Genetic;in vivo;innovation;Intervention;Malignant Neoplasms;MAPK3 gene;Mediating;Microscopy;Modeling;Molecular;Mutation;National Institute of General Medical Sciences;new therapeutic target;novel diagnostics;novel therapeutic intervention;Outcome;Pathway interactions;Patients;programs;Proteins;public health relevance;Research;scaffold;Scaffolding Protein;segregation;Signal Pathway;Signal Transduction;Sorting;Spatial Distribution;Specificity;Syndrome;targeted treatment;therapeutic development;transmission process;tumor;Ubiquitin;virtual;Vision;Work;Zebrafish

PROJECT_TITLE: Mechanisms and functions of Shoc2-transduced cellular signals

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: AI

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Although several model systems exist for bacterial viruses, the proposed research will result in a greater mechanistic understanding of the diversity these viruses use to recognize their host cells, replicate and assemble to produce additional progeny viruses, and persist in the environment. Given the ongoing issues with antibiotic resistance and renewed interest in using viruses to combat bacterial infections, these goals are relevant to human health by specifically addressing current issues with phage therapy. This proposal is relevant to the NIAID’s mission by providing foundational information for treating infectious diseases or detecting bacterial contamination prior to infection by specifically examining the interactions between these viruses and the causative agent of bacillary dysentery, Shigella flexneri.

PI_NAMEs: DOORE, SARAH M (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Address;Affect;Affinity;Antibiotic Resistance;antibiotic resistant infections;Bacteria;Bacterial Infections;Bacteriophages;Binding;Binding Proteins;Biochemical;Biological;Biological Assay;Biological Models;Biological Process;Biology;Capsid;Cells;Cessation of life;Characteristics;Citrobacter freundii;Clinic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;combat;Combating Antibiotic Resistant Bacteria;Communicable Diseases;Complication;crosslink;Cryo-electron tomography;Cryoelectron Microscopy;Data;Data Analyses;Data Set;Death Rate;Developing Countries;Diarrhea;Disease;Dysentery;Engineering;Enteral;Environment;Escherichia coli;Etiology;Evolution;experimental study;fitness;Florida;Food;Functional disorder;Gastrointestinal tract structure;gel electrophoresis;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic analysis;Genetic Transcription;Genome;Geometry;Goals;Gram-Negative Bacteria;gut bacteria;Health;Human;Human body;imaging modality;In Vitro;in vivo;Industrialization;Infection;innovation;interest;Kinetics;knock-down;Knock-out;Lipopolysaccharides;Location;Lytic;Mass Spectrum Analysis;Measures;Medical;Membrane Proteins;Michigan;Mission;Modeling;Multicenter Studies;Mutagenesis;mutant;National Institute of Allergy and Infectious Disease;next generation sequencing;novel;novel therapeutics;opportunistic pathogen;Organism;Outcome;particle;pathogen;pathogenic bacteria;Pathway interactions;Phage Receptors;Planets;Preventive therapy;Preventive treatment;Production;Property;Protein Analysis;Proteins;receptor;recruit;Research;Resolution;ribosome profiling;Risk;RNA Sequences;Salmonella enterica;Series;Serotyping;Shigella;Shigella flexneri;Shigella Infections;Specificity;Stress;Structure;Surface;System;Tail;Techniques;Tertiary Protein Structure;Testing;Time;transcriptome sequencing;Transfer RNA;Universities;Viral;Virus;Water;Work;World Health Organization

PROJECT_TITLE: Mechanisms of interaction between bacteriophage and their hosts throughout the infection cycle

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ORG_CITY: NORFOLK

ORG_NAME: EASTERN VIRGINIA MEDICAL SCHOOL

ORG_STATE: VA

PHR: PROJECT NARRATIVE Prostate Cancer is a serious health crisis in the United States and remains the second leading cause of cancer-related male deaths despite implementation of new screening methods and therapeutic drugs for this disease. Glycosylation, involving the covalent attachment of carbohydrates onto proteins and lipids, is shown to impact their molecular stability, cellular localization, biological function and malignancy - but virtually nothing is known about the new field of glycosylated RNAs (glycoRNAs) or their role in human disease such as prostate cancer. Innovative/exploratory work described in this proposal employing a spectrum of human prostate cancer cell lines and an in vivo mouse model for prostate cancer will drastically improve our understanding of glycoRNA mechanisms involved during prostate tumor progression and lead to novel RNA-based biomarker and treatment strategies for lethal prostate cancer.

PI_NAMEs: KERSCHER, AURORA ESQUELA (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: advanced disease;angiogenesis;Animals;Apoptosis;Area;Azides;Benign;Biological;Biological Markers;Biological Process;biomarker development;Biotinylation;Cancer Biology;cancer biomarkers;Cancer Etiology;Cancer Patient;cancer prevention;cancer therapy;Carbohydrates;cell growth;Cell Line;Cell surface;Cells;Cellular Membrane;Cessation of life;Chemicals;Chemistry;Classification;Clinical;Colon;Comparative Study;Cultured Cells;curative treatments;Diagnosis;Disease;Disease Progression;Distant;Ensure;Enzymes;exosome;Extracellular Matrix;extracellular vesicles;Fractionation;Glycolipids;Glycoproteins;glycosylation;Golgi Apparatus;Health;Homeostasis;hormone sensitivity;Hormones;Human;human disease;Immune response;Immune System Diseases;Immunologic Surveillance;improved;in vivo;inhibitor;innovation;Inosine;insight;intercellular communication;Invaded;Knockout Mice;Label;Lectin;Link;Lipids;Liquid substance;male;Malignant - descriptor;Malignant neoplasm of prostate;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;men;Metabolic;Methods;Modification;Molecular;Monitor;Morphologic artifacts;mouse model;Mus;Mutant Strains Mice;Neoplasm Metastasis;Non-Malignant;Northern Blotting;novel;Nucleic Acids;nucleocytoplasmic transport;Oncogenic;Organ;Pancreas;Pathology;Pathway interactions;patient stratification;Patient-Focused Outcomes;Patients;Pattern;Pharmaceutical Preparations;Play;Polysaccharides;Population;Post-Transcriptional RNA Processing;Post-Translational Protein Processing;posttranscriptional;Process;Prognosis;Prostate;prostate cancer cell;prostate cancer cell line;prostate cancer model;prostate cancer progression;Prostate Cancer therapy;Prostatic Intraepithelial Neoplasias;Prostatic Neoplasms;Protein Glycosylation;Proteins;Pseudouridine;Recurrent disease;response;RNA;Role;screening;Screening procedure;Sialic Acids;sialylation;Signal Transduction;Site;sugar;Survival Rate;survivorship;Tail;Testing;Therapeutic;Time;Tissues;tool;transcriptome sequencing;translational potential;treatment strategy;tumor growth;tumor progression;Tumor Suppressor Genes;tumorigenic;United States;Untranslated RNA;Uridine;virtual;Work

PROJECT_TITLE: Developing glycosylated RNAs as novel clinical targets for aggressive prostate cancer.


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Liver Disease;Nutrition;Obesity

PHR: Project Narrative The proposed studies will examine the mechanism by which a novel protein regulates hepatic lipid and glucose metabolism. This research is relevant to public health because it is anticipated that the results will improve our understanding of the relationships between obesity and metabolic disorders. The proposed studies are relevant to the mission of the NIDDK because they are expected to identify new therapeutic approaches for the management of common disorders related to excessive lipid accumulation.

PI_NAMEs: ERSOY, BARAN  (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Ablation;Acetyl Coenzyme A;Acyl Coenzyme A;Adipocytes;Adipose tissue;Anabolism;Biological Availability;Body Weight decreased;Caenorhabditis elegans;Cells;Ceramides;Citric Acid Cycle;Climate;Closure by clamp;Consumption;Data;Deacetylase;Defect;design;Diet;Dietary Fats;Dietary Sugars;Diglycerides;Disease;Endoplasmic Reticulum;endoplasmic reticulum stress;Energy Metabolism;Esterification;Exhibits;experimental study;Family member;Fatty Acids;Fractionation;Glucose;glucose metabolism;glucose production;Goals;Hepatic;Hepatocyte;Histology;Homeostasis;Human;Hydrolysis;Immunoblot Analysis;Impairment;improved;In Vitro;Indirect Calorimetry;Inner mitochondrial membrane;Insulin Resistance;insulin sensitivity;insulin signaling;Intervention;knock-down;Knockout Mice;lipid biosynthesis;lipid metabolism;lipidomics;Lipids;Liver;Lysine;Measurement;Measures;Mediating;Membrane;Metabolic;Metabolic Diseases;metabolomics;Mission;Mitochondria;Mitochondrial Matrix;Molecular;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;non-alcoholic fatty liver disease;Nonesterified Fatty Acids;novel;novel therapeutic intervention;Nutrient;Obesity;Outcome;Overnutrition;Oxidative Stress;Pathogenesis;Pathway interactions;pharmacologic;Phosphorylation;Plasma;Prevention;Production;Protein Acetylation;Protein Kinase C;Proteins;Public Health;Publishing;Reactive Oxygen Species;Recombinants;Regulation;Research;Research Proposals;Resolution;response;RNA Interference;Role;Sirtuins;sugar;Testing;Therapeutic;Thermogenesis;Tissues;trafficking

PROJECT_TITLE: Thioesterase-mediated lipotoxicity in liver and thermogenic adipose tissue


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE This learning project will provide critical knowledge regarding how brain network dysfunction contributes to depression, from the example of white matter lesions in multiple sclerosis.Predictors of depression symptomatology from white matter lesions could be used for treatment stratification in clinical trials using personalized biomarkers. Such knowledge would benefit public health by reducing the costs and burden of depression on society at large.

PI_NAMEs: BALLER, ERICA BERLIN (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Acceleration;Adult;Affect;Age;algorithmic methodologies;Atrophic;Attention;automated segmentation;biotypes;Brain;Brain region;Chronic Disease;Clinical;Clinical assessments;clinical care;Clinical Trials;Cognition;cognitive function;cognitive testing;comorbid depression;comorbidity;Computational Technique;Computerized Medical Record;Computing Methodologies;cost;Data;Data Set;depressive symptoms;Diagnosis;Dimensions;Disease;Dorsal;Exclusion;experience;Fascicle;Female;Fiber;Foundations;Functional disorder;gray matter;Heterogeneity;Image;Immune;Impairment;individual variation;instrument;Knowledge;Learning;Lesion;Location;machine learning algorithm;machine learning method;Magnetic Resonance Imaging;male;Maps;Measures;Mediating;Mediation;Medical;Mental Depression;Mentored Patient-Oriented Research Career Development Award;Mentorship;Mimosa;Modeling;Multiple Sclerosis;network dysfunction;Neurocognitive;neuropsychiatric symptom;Participant;Patients;Pattern;Pennsylvania;Performance;personalized biomarkers;Persons;Phenotype;predictive modeling;Prevalence;Process;programs;prospective;psychiatric symptom;Psychiatry;Public Health;Recording of previous events;recruit;Reproducibility;Research;Sampling;Severities;Sex Differences;Societies;Stroke;Structure;supervised learning;Symptom Burden;symptomatology;System;Techniques;Testing;tool;Training;treatment stratification;United States;University resources;Visit;white matter;White Matter Disease

PROJECT_TITLE: Depression as a disease of network disruption:  learning from multiple sclerosis

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Neurodegenerative;Neurosciences;Patient Safety;Peripheral Neuropathy;Prevention;Radiation Oncology;Rare Diseases;Rehabilitation

ORG_CITY: HOUSTON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE The incidence of highly curable head and neck cancers is rapidly rising and there are more long-term survivors than ever. Radiation treatment is very commonly given at doses sufficient to cause crippling late cranial neuropathy (nerve dysfunction) and dysphagia (difficulty swallowing) that can progress to the point that it results in a lifelong feeding tube or death from aspiration pneumonia even after cancer is cured. This application seeks to understand how abnormal nerve function in the tongue may be present and measured long before it is evident in clinic, hopefully to provide an earlier therapy target to help swallowing function before irreversible damage is done.

PI_NAMEs: HUTCHESON, KATHERINE ARNOLD (contact);SANCHEZ TERRONES, BENJAMIN

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Address;Algorithms;aspirate;Aspiration Pneumonia;Barium swallow;cancer radiation therapy;Cancer Survivor;Cancer Survivorship;Cessation of life;Chronic;Classification;Clinic;Clinical;Clinical Data;Clinical Management;clinical risk;Clinical Trials;cohort;Continuance of life;Cranial nerve diseases;Data;Data Collection;Data Set;Deglutition;Deglutition Disorders;Denervation;density;Detection;Devices;Diagnosis;Diet;Dose;Early treatment;Edema;Electromyography;Electronics;Enrollment;Enteral Feeding;Fibrosis;Functional disorder;genioglossus muscle;Goals;Head and Neck Cancer;Health;high reward;high risk;Incidence;Infrastructure;Injury;Life;Link;Long Term Survivorship;Long-Term Survivors;Malignant Neoplasms;malignant oropharynx neoplasm;Measurable;Measurement;Measures;Methods;Modernization;Modification;Monitor;mortality risk;Muscular Atrophy;Needles;Nerve;nerve injury;Neuropathy;Normal tissue morphology;novel;Oral;Oropharyngeal;Outcome;Outcome Measure;Paralysed;Pathogenesis;Patient Outcomes Assessments;Patients;personalized management;Pneumonia;Population;Positioning Attribute;Prevalence;Procedures;Publishing;Quality of life;Radiation;Radiation Fibrosis;Radiation therapy;Radiation Toxicity;radiological imaging;Recovery of Function;Reproducibility;Research Personnel;Sampling;screening;Severities;Signal Transduction;Surface;Survivors;survivorship;Symptom Burden;System;targeted treatment;Therapeutic;Time;tissue injury;Tongue;Toxic effect;Work

PROJECT_TITLE: Hypoglossal neuropathy in the pathogenesis of radiation associated dysphagia (hRAD)


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Atherosclerosis;Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Eye Disease and Disorders of Vision;Heart Disease;Heart Disease - Coronary Heart Disease;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative This project develops novel imaging capabilities for optical coherence tomography (OCT) systems in the clinic. Analyzing the polarization state of the OCT light may enable earlier detection of glaucoma, which is the leading cause of irreversible blindness. Used for intracoronary imaging after myocardial infarction and coronary syndromes, it may improve patient management and help prevent future adverse coronary events.

PI_NAMEs: VILLIGER, MARTIN  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: Acute;Acute Coronary Event;Adoption;Algorithms;Angiography;Anisotropy;Arterial Fatty Streak;Atherosclerosis;Axon;axonal degeneration;base;Biological Markers;Birefringence;Blindness;Cadaver;Cardiac Catheterization Procedures;Catheters;Cause of Death;Clinic;Clinical;clinical application;clinical imaging;Clinical Research;clinical translation;Collaborations;Communities;Compensation;Coronary;Coronary Arteriosclerosis;Coronary artery;coronary event;cost;Custom;Data;denoising;Detection;Development;Diagnosis;Early Diagnosis;economic cost;empowerment;Eye;Fiber;Fiber Optics;Future;Glaucoma;Goals;healing;Heart;Image;image reconstruction;imaging capabilities;Imaging Device;imaging modality;imaging platform;improved;Infrastructure;insight;instrument;Intervention;Investigation;Light;Lighting;Lung;lung imaging;Magnetic Resonance Imaging;Mammary Neoplasms;Measurement;Measures;Medical;Methods;Modification;Monitor;Myocardial Infarction;Neurodegenerative Disorders;Noise;novel;open source;Ophthalmology;Optical Coherence Tomography;Optics;Patients;Pattern;percutaneous coronary intervention;Pilot Projects;polarimetry;preservation;prevent;Property;prototype;reconstruction;Recovery;Research;Resolution;response;Retina;Retinal Ganglion Cells;retinal imaging;retinal nerve fiber layer;Rotation;Rupture;Scanning;Sclera;signal processing;Signal Transduction;Structure;Syndrome;System;Thinness;Tissues;United States;Validation;Variant;Vision;Work

PROJECT_TITLE: Universal optical coherence polarimetry

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Recent advances in HIV science make ending the epidemic achievable, yet barriers to implementing proven strategies in practice persist. HIV disparities, rising incidence of HIV in marginalized populations, increasingly complex HIV co-morbidities, presence of social and structural barriers, and the need for cost-effective approaches present continuing challenges to public health. CIRA will provide a nexus for scientific inquiry and research collaborations to advance implementation of effective solutions to the epidemic in the U.S and globally.

PI_NAMEs: KERSHAW, TRACE S (contact)

PROGRAM_OFFICER_NAME: GORDON, CHRISTOPHER M

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adoption;AIDS prevention;anti-racism;Area;Behavioral;Black race;Caring;Clinical;Collaborations;Colonialism;Communities;community engaged research;Community Outreach;community partners;comorbidity;Complex;Continuity of Patient Care;cost effective;cost effectiveness;Country;design;Development;digital health;Disparity;dissemination science;Effectiveness;empowerment;Environment;Epidemic;Equity;Evaluation;Fostering;gender minority group;Goals;Grant;Health;health equity;Health equity research;Health Services Research;Health Technology;HIV;HIV disparities;implementation science;implementation strategy;improved;Incidence;Individual;Inequity;Infection;innovation;Institution;Interdisciplinary Study;International;Intervention;Investments;Justice;Knowledge;Learning;lens;marginalized community;marginalized population;Measures;Mental Health;Mentors;Methods;Mission;Modeling;Monitor;multidisciplinary;Neighborhoods;New England;next generation;Outcome;person centered;Policies;Prevention Research;prevention service;Process;Public Health;racism;Research;Research Personnel;Resource-limited setting;Resources;response;Role;scale up;Science;Scientific Advances and Accomplishments;Scientific Inquiry;Scientist;Services;sexual minority group;skills;social;social determinants;Social Justice;social media;Social Network;social stigma;Strategic Planning;structural health determinants;substance use;substance use treatment;success;theories;Time;tool;Training;Training Programs;Translating;transmission process;treatment services;Universities;urban area;Writing

PROJECT_TITLE: Center for Interdisciplinary Research on AIDS


ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: PROJECT NARRATIVE Many cancers, including metastatic prostate cancer, resist molecularly targeted therapy by altering their phenotype from one that is dependent on the target to one that is not. Here we characterize genetic mutations and epigenetic mechanisms that drive transformation from androgen dependent prostate cancer to androgen independent prostate cancer. The goal is to identify new approaches for treating lethal prostate cancers.

PI_NAMEs: GOODRICH, DAVID W. (contact)

PROGRAM_OFFICER_NAME: LIU, ZHIHUI

PROJECT_TERMS: abiraterone;Acetates;Address;androgen deprivation therapy;androgen independent prostate cancer;Androgen Metabolism;Androgen Receptor;androgen sensitive;Androgens;antagonist;ASCL1 gene;Automobile Driving;cancer cell;Cancer Patient;cell transformation;Cells;Characteristics;Clinical;Collection;Combined Modality Therapy;CYP17A1 gene;Data;derepression;design;Development;Disease Resistance;DNA Methyltransferase Inhibitor;DNA Sequence Alteration;Drug Modulation;effective therapy;Engineering;enzalutamide;Epigenetic Process;Epithelium;Experimental Models;EZH2 gene;Genetic;Goals;Human;Human Cell Line;improved;Incidence;individual patient;inhibitor;Knowledge;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Mediating;Metastatic Prostate Cancer;Modeling;Molecular;molecular targeted therapies;Mouse Cell Line;mouse model;Mutation;Neuroendocrine Prostate Cancer;Neurosecretory Systems;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;phenotypic biomarker;Positioning Attribute;Prostate;Prostate Adenocarcinoma;prostate cancer cell;Prostate Cancer therapy;Publishing;RB1 gene;receptor expression;Receptor Signaling;Relapse;relapse patients;Research;Resistance;response;Science;Signal Transduction;single cell analysis;Specimen;Testing;Therapeutic;therapeutically effective;therapy resistant;Time;Tissues;TP53 gene;treatment response;Tumor Suppressor Genes;Variant;Work

PROJECT_TITLE: NOTCH signaling controls transformation to androgen independent neuroendocrine prostate cancer

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

PROJECT_TERMS: Achievement;Acquired Immunodeficiency Syndrome;Address;AIDS prevention;anti-racism;Area;Behavioral;Caring;Collaborations;Communication;Communities;community engaged research;community partners;comorbidity;Connecticut;Continuity of Patient Care;Decision Making;Development;digital health;Disparity;effectiveness evaluation;Epidemic;Equity;Evaluation;falls;Feedback;Fostering;Funding;Future;Goals;Health;health equity;HIV;HIV disparities;implementation facilitation;implementation science;improved;Individual;Inequity;Information Technology;Infrastructure;innovation;Interdisciplinary Study;International;Knowledge;Lead;Leadership;lens;Lived experience;Measures;Mental Health;Mission;Monitor;multidisciplinary;National Institute of Mental Health;Nature;New England;next generation;operation;Organizational Change;Performance;Play;prevention service;Process;programs;Public Health;racism;Research;research and development;research data dissemination;Research Personnel;Research Support;Resources;Role;Running;Schedule;Scientist;service organization;Services;skills;social;social determinants;social stigma;Strategic Planning;substance use;success;synergism;System;Techniques;Teleconferences;Time;tool;Training;Training Programs;treatment services;Voice;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Breastfeeding, Lactation and Breast Milk;Cancer;Clinical Research;Genetics;Nutrition;Prevention;Women's Health Research

ORG_CITY: HADLEY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: Project Narrative This project conducts early-stage development of a paper-based device to facilitate the efficient recovery of high-quality nucleic acids from breastmilk for use in breast cancer risk assessment and national epidemiologic studies. The proposed device will facilitate the collection and loading of breastmilk on a small paper card which can be sent through the mail and stored flat at room temperature for long times, or indefinitely, allowing subsequent recovery of nucleic acids. The project addresses the requirement to process relatively large volumes of breastmilk on the card and develops a means to retain nucleic acids while drawing excess fluid into a disposable layer.

PI_NAMEs: SANTORE, MARIA M. (contact)

PROGRAM_OFFICER_NAME: CARRICK, DANIELLE M

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Affect;anti-cancer research;Birth;Blood;Blood capillaries;Breast;Breast Cancer Risk Factor;Breast Epithelial Cells;Breast Feeding;Cancer Burden;cancer risk;Cancerous;Cells;Chemistry;Collecting Cell;Collection;design;Detection;detection limit;Development;Device Designs;Devices;Diagnosis;Diet;Disease;disorder risk;DNA;DNA analysis;Dryness;Early Diagnosis;Early identification;Effectiveness;Eligibility Determination;epidemiology study;Epigenetic Process;Epithelial Cells;Etiology;Event;Excision;Exposure to;Failure;Fiber;Freezing;Future;Geographic Locations;Home;Human;Human Milk;Ice;improved;Individual;innovation;insight;Knowledge;Liquid substance;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary gland;Mammary Gland Parenchyma;Methods;methylation pattern;Milk;Modeling;Molecular;Mutation;Nucleic Acids;Paper;Performance;Pharmaceutical Preparations;Phase;Population;Pregnancy;premalignant;prevent;Primary Prevention;Privacy;Process;programs;Property;prototype;Recommendation;Recovery;Refrigeration;Research Design;Research Personnel;Risk Assessment;Shapes;Shipping;Somatic Mutation;Specimen;Surface;System;Temperature;Testing;Time;Tissues;Woman;young woman

PROJECT_TITLE: Paper-based Breastmilk Collection System for Facile, In-Home Use


NIH_SPENDING_CATS: Dietary Supplements;Digestive Diseases;Genetics;Infectious Diseases;Microbiome;Nutrition;Prevention

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Soil-transmitted helminth infections represents a significant global public health and economic burden. Therefore, there is an urgent need to improve our understanding of genetic and environmental modulators of type 2 cytokine-dependent immunity in order to identify novel preventative and therapeutic approaches for this group of infectious agents. Based on our new preliminary data, the focus of this proposal is to dissect the influence of diet-induced modulation of microbiota-derived metabolites in regulating type 2 cytokine responses and protective immunity to helminth infection.

PI_NAMEs: ARTIS, DAVID  (contact);GUO, CHUN-JUN

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: absorption;Acceleration;Acids;Address;Adoptive Cell Transfers;Allergic Disease;allergic response;Anemia;Antiinflammatory Effect;B-Lymphocytes;Bacteria;bile acid metabolism;Bile Acids;Biological;Biology;Blood Circulation;Brain;Cells;Chemicals;Cholic Acids;Chronic;cognitive function;Communicable Diseases;comparative;cytokine;Data;dehydroxylation;Deoxycholic Acid;Development;Diet;Dietary Component;Dietary Fiber;dietary requirement;Distant;Economic Burden;Economics;Environmental Risk Factor;eosinophil;Eosinophilia;Fermentation;Fiber;Gene Deletion;Gene Expression;Gene Expression Profiling;Genetic;genetic approach;Genetic Engineering;Germ-Free;Growth;helminth infection;Helminths;IgE;Immune;Immune response;Immunity;Immunoglobulin G;Immunologics;immunopathology;immunoregulation;Impaired cognition;improved;In Vitro;in vivo;Individual;Indoles;Infection;infection rate;Infectious Agent;Inflammation;Inflammatory;Inflammatory Response;Intestines;Inulin;Lymphoid Cell;Macrophage;Malnutrition;Mammalian Cell;Mediating;member;mesenchymal stromal cell;Metabolic;Metabolic Pathway;metabolomics;microbial;microbiota;microbiota composition;microbiota metabolites;mouse model;Mus;mutant;neglect;novel;overexpression;Parasites;Parasitic infection;Pathway interactions;Persons;Physiological;prevent;Production;Public Health;receptor;Regulation;response;Role;secondary metabolite;Site;Soil;Source;Stromal Cells;Testing;Th2 Cells;Therapeutic;Tissues;tool;transcriptional reprogramming;transcriptomics;transmission process;Volatile Fatty Acids

PROJECT_TITLE: Microbiota-derived metabolites and the regulation of host immunity and inflammation

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cancer;Dementia;Natural Products;Neurodegenerative;Nutrition;Obesity

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: Project Narrative  Protein tyrosine phosphatases contribute to an enormous number of diseases (e.g., diabetes, obesity, cancer, Alzheimer's disease, autoimmunity, and heart disease) but lack targeted therapeutics. This project uses microorganisms to build molecules that inhibit or activate these enzymes. In doing so, it builds a framework for molecular discovery that will facilitate the study, design, and assembly of new varieties of therapeutic agents.

PI_NAMEs: FOX, JEROME  (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Alzheimer's Disease;Anabolism;Analgesics;Anti-Inflammatory Agents;Antineoplastic Agents;Autoimmune Diseases;Biological;Biological Availability;Biophysics;cell behavior;Chemicals;Complex;cytotoxic;design;Development;Diabetes Mellitus;Disease;Drug Targeting;Engineering;Enzymes;Event;Evolution;Exhibits;Goals;guided inquiry;Heart Diseases;Human;inhibitor;interest;Kinetics;Laboratories;Logic;Malignant Neoplasms;Mediating;Medicine;Metabolism;Methods;microbial;microbial host;microorganism;Molecular;molecular assembly/self assembly;Natural Products;novel strategies;Obesity;operation;pharmacologic;Pharmacologic Substance;Preparation;Process;programs;Property;protein folding;Protein Tyrosine Phosphatase;Role;signal processing;Signal Transduction;small molecule;Source;Structure;synthetic biology;System;targeted treatment;Therapeutic;Therapeutic Agents;Therapeutic Effect;Viral;Work

PROJECT_TITLE: Microbially guided discovery and biosynthesis of biologically active natural products

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]