NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Childhood Injury;Neurodegenerative;Neurosciences;Pediatric;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Transplantation;Traumatic Head and Spine Injury

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative The goal of this research is to develop and optimize an innovative three-dimensional (3D) printing platform for the fabrication of intelligent nerve conduits to repair damaged nerves in a pediatric population. The printed 3D conduit is created to match the size and shape of the damaged nerve site and with embedded wireless sensors for on-demand reporting. This work has significant potential impact as infants and children are particularly susceptible to peripheral nerve injuries through the birthing process, trauma, tumors, and underlying medical conditions such as diabetes and autoimmune disorders, and thus, make up a significant proportion of the estimated 50,000 - 200,000 surgeries required for peripheral nerve injuries annually.

PI_NAMEs: CHEN, SHAOCHEN  (contact);NGUYEN, QUYEN

PROGRAM_OFFICER_NAME: PILEGGI, ANTONELLO

PROJECT_TERMS: 18 year old;3-Dimensional;3D Print;Autoimmune Diseases;Autologous;Autologous Transplantation;axon growth;axon regeneration;Biocompatible Materials;biomaterial compatibility;Biomimetics;bioprinting;Birth;Body part;Brachial plexus structure;Child;Childhood;Clinical;clinical translation;Collection;Commercial grade;commercialization;Computer-Aided Design;Data;Defect;design;Devices;Diabetes Mellitus;Diagnostic;digital;Dimensions;Distal;Electrophysiology (science);Engineering;Evaluation;fabrication;FDA approved;flexibility;Gelatin;Generations;Geometry;Goals;Growth;Harvest;Head and neck structure;head/neck injury;Human;hydrogel scaffold;Image;image guided;Implant;implanted sensor;In Situ;Infant;injured;Injury;innovation;Length;loss of function;Lower Extremity;Magnetic Resonance Imaging;manufacture;Medical;meetings;meter;Methods;Modeling;Monitor;Morbidity - disease rate;MRI Scans;Mus;Nerve;nerve damage;Nerve Fibers;nerve injury;Nerve Regeneration;nerve repair;Nerve Tissue;neural;neural graft;Neuroma;nonhuman primate;Numbness;Operative Surgical Procedures;Paralysed;Patients;pediatric patients;Performance;Peripheral nerve injury;peripheral nerve repair;poly(ethylene glycol)diacrylate;Polymers;Population;pre-clinical;Predisposition;Printing;Procedures;Process;Prognosis;Property;real time monitoring;Recovery;Recovery of Function;regenerative;regenerative therapy;repaired;Reporting;Reproducibility;Research;scaffold;sciatic nerve;sciatic nerve injury;sensor;sex;Shapes;Side;Site;Source;Specific qualifier value;Spinal cord injury;Structure;success;System;Techniques;Testing;Therapeutic;Time;Translations;Trauma;tumor;Upper Extremity;Validation;Vascularization;wireless;wireless sensor;Work

PROJECT_TITLE: Pre-clinical validation of 3D-printed nerve conduits for pediatric peripheral nerve repair


ADMINISTERING_IC: HD

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE The gut microbiome affects multiple aspects of human health and has been causally linked to a wide range of medically important conditions including cancer, heart disease, chronic lung diseases, and autoimmunity. Despite our advance in understanding the mechanism by which the gut microbiome causes disease, there is no straightforward clinical diagnostic test to measure “gut health.” Our proposal is highly relevant to public health because it will advance a new strategy to aid development of a non-invasive breath-based readout of the gut microbiome.

PI_NAMEs: KAU, ANDREW LEON;ODOM JOHN, AUDREY RAGAN (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: absorption;Admission activity;Affect;Age;Age Months;Anabolism;Animal Husbandry;Antibiotic Therapy;Antibiotics;aspirate;Autoimmunity;Bacteria;bacterial metabolism;Bacteroides fragilis;Biological;Biological Markers;Birth;breath composition;Breath Tests;candidate validation;Catabolism;Catalogs;Characteristics;Childhood;Chronic lung disease;Clinical;clinical diagnostics;Clinical Research;cohort;Cohort Studies;Commerce;COVID-19;Data;Development;Diagnosis;Diagnostic;Diagnostic tests;Diet;Disease;Disulfides;dysbiosis;Ecology;Enrollment;Ensure;Environmental Exposure;Evaluation;Exhalation;experience;fecal microbiota;Fever;Food Processing;Genetic study;Genetic Transcription;Germ-Free;Gnotobiotic;Goals;gut health;gut microbes;gut microbiome;gut microbiota;Health;Heart Diseases;Human;human disease;Immune system;Immunity;improved;In Vitro;Individual;infancy;Infant;innovation;Investigation;Knowledge;Link;Lyase;Malignant Neoplasms;Malnutrition;Measurement;Measures;Medical;member;Metabolic;Metabolic Pathway;Metabolism;metagenomic sequencing;Metagenomics;metatranscriptomics;Methionine;Methodology;microbial;microbiome research;Molecular;mouse model;Mus;Nervous System Physiology;novel strategies;Patient Care;Pattern;Pharmaceutical Preparations;point of care testing;Population;Prospective cohort;Public Health;Research;response;Shapes;Specimen;stool sample;success;System;Technology;Testing;Therapeutic;Time;volatile organic compound;Volatilization;Work

PROJECT_TITLE: Breathprinting as a window into gut microbiome chemoecology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-N(80)]


ADMINISTERING_IC: AI

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: BLACKSBURG

ORG_DEPT: ZOOLOGY

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE The proposed research on rabies spillover from wildlife to humans and livestock is relevant to public health because pathogen spillover (i) can generate highly infectious emerging zoonotic diseases, (ii) can cause human and economic losses, and (iii) generally originates from wildlife. Little is known about ecological drivers of rabies spillover (and pathogen spillover more generally), including why some geographic areas are infected while others are not. This proposal represents a novel theoretical and analytical approach to understand pathogen spillover transmission, which is directly relevant to NIH’s mission to seek fundamental knowledge of the nature of living systems and application of that knowledge to enhance human health.

PI_NAMEs: ESCOBAR, LUIS E (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Achievement;Address;Americas;Animals;Area;Biodiversity;Bioinformatics;Biology;career;Cattle;Characteristics;Chiroptera;Classification;Climate;Communicable Diseases;COVID-19;Data;Development;Disease;disease diagnostic;Doctor of Philosophy;Domestic Animals;Ebola;Ecology;Economics;Environmental Risk Factor;Epidemiology;epidemiology study;Evolution;Expenditure;Exposure to;Funding;Genetic Structures;genomic data;Genomics;Geographic Distribution;Geographic Factor;Geographic Locations;Geography;Goals;Habitats;Health;Human;improved;Incidence;Individual;Industry;Infection;innovation;insight;Institution;Knowledge;Laboratories;Latin America;Link;Livestock;Machine Learning;machine learning model;Mammals;Measures;Medical;Mentors;Methods;Mexico;Minnesota;Mission;Modeling;Molecular Epidemiology;mortality;multiple datasets;Nature;Nipah;novel;Organism;pathogen;pathogen spillover;Pattern;Persons;Phylogenetic Analysis;post-doctoral training;prevent;Prevention;previous epidemic;professor;Public Health;Rabies;Rabies Vaccines;Rabies virus;Recording of previous events;Report (document);Research;Research Personnel;Research Project Grants;Research Proposals;Risk;Role;Shapes;Signal Transduction;skills;Solid;spatial epidemiology;System;technological innovation;Temperature;tenure track;Testing;Training;transmission process;United States;United States National Institutes of Health;Universities;viral transmission;Virginia;Virus;Zoonoses

PROJECT_TITLE: Mentored Research (K01) Integrative Spatial Epidemiology Study of Wildlife Rabies Spillover

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Clinical Research;Lung;Mental Health;Pediatric;Precision Medicine

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Preschool children with recurrent wheezing are a heterogeneous group with differing symptom presentations that likely contribute to differing longitudinal clinical outcomes. Given extremely limited symptom science in this population, the primary objectives of this cohort study are to are to determine whether symptom cluster predicts exacerbation (primary outcome) and quality of life (secondary outcome). Secondary goals are to identify pathways through next-generation sequencing that can be targeted in future personalized intervention studies to reduce morbidity and costs.

PI_NAMEs: FITZPATRICK, ANNE MENTRO (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: 6 year old;Address;Adrenal Cortex Hormones;Affect;affective disturbance;Age;Anxiety;Area;associated symptom;Asthma;Award;Biological;career development;Caregivers;Child;Chronic Disease;Clinical;Clinical Research;cohort;Cohort Studies;Collaborations;Complex;cost;Disease;Economic Burden;Education;Emergency department visit;Ensure;Environment;Esthesia;experience;Family;Fatigue;Fostering;functional status;Future;Gene Expression Profile;Goals;Health;hospitalization rates;impaired functional status;Impairment;improved;Incidence;Inflammatory;Infrastructure;innovation;Intervention Studies;Malignant Neoplasms;Mental Depression;Mental Health;Mentors;Molecular Biology;Morbidity - disease rate;mRNA sequencing;next generation sequencing;novel marker;Nursery Schools;Outcome;Pain;Pathway interactions;patient oriented;patient oriented research;Patient Outcomes Assessments;personalized intervention;Phenotype;physical conditioning;physical symptom;Play;Population;precision medicine;predict clinical outcome;Preschool Child;Prevalence;primary outcome;Principal Investigator;Productivity;programs;Psyche structure;Public Health;Quality of life;Recurrence;Research;Research Activity;Research Design;Resources;Respiratory Signs and Symptoms;Role;secondary outcome;Severities;Sleep disturbances;social;Statistical Methods;Statistical Study;Strategic Planning;symptom cluster;symptom science;Symptoms;Testing;therapy design;Time;Training;United States;Universities;Virus Diseases;Wheezing;Work

PROJECT_TITLE: Mentored patient-oriented research in preschool wheezing disorders

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(77)]


NIH_SPENDING_CATS: Asthma;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lung;Pediatric;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: NARRATIVE It is urgent to understand the effects of SARS-CoV-2 on children better. Here we study how highly SARS-CoV-2 exposed NYC children of all ages and with asthma react to common cold viruses to understand the implications of natural infection on subsequent respiratory virus infec- tions, as well as reinfections with SARS-CoV-2 variants.

PI_NAMEs: WORGALL, STEFAN  (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 17q21;2019-nCoV;Address;Adult;Affect;Age;age group;age related;airway epithelium;Alleles;Antibodies;Asthma;asthma exacerbation;asthmatic;ATAC-seq;Binding;Blood;Cells;Child;Childhood;Childhood Asthma;Chronic;chronic inflammatory disease;chronic respiratory disease;Clinic;cohort;Common Cold Virus;COVID-19 outbreak;COVID-19 pandemic;COVID-19 prevalence;COVID-19 vaccine;Data;Disease;Enrollment;Epigenetic Process;Epithelial Cells;Ethnic Origin;Frequencies;Gene Expression;Genetic;Genetic Polymorphism;Genetic Predisposition to Disease;Genetic Variation;health disparity;Hematopoietic stem cells;Immune;Immune response;Immunology;immunoregulation;Impairment;Incidence;Infection;Inflammasome;Inflammatory;Inflammatory Response;Link;Masks;Membrane;Metabolism;Minor;Monitor;Mucous Membrane;Nasal Epithelium;New York City;Nose;Nuclear;Outcome;pandemic disease;Pathogenesis;pathogenic virus;peripheral blood;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;post SARS-CoV-2 infection;progenitor;programs;protective effect;Questionnaires;Race;Reaction;receptor expression;Reporting;respiratory;respiratory health;respiratory infection virus;respiratory pathogen;Respiratory syncytial virus;respiratory virus;response;Rhinovirus;Rhinovirus infection;Risk Factors;risk variant;Sampling;SARS-CoV-2 B.1.1.529;SARS-CoV-2 exposure;SARS-CoV-2 infection;SARS-CoV-2 pathogenesis;SARS-CoV-2 variant;severe COVID-19;Severities;Shapes;single-cell RNA sequencing;Social Distance;socioeconomics;Sphingolipids;Stimulus;T-Lymphocyte;Testing;transcriptomics;uptake;Vaccines;Variant;VDAC1 gene;Viral;Viral Respiratory Tract Infection;Virus Diseases;Wheezing

PROJECT_TITLE: Impact of SARS-CoV-2 infection on respiratory viral immune responses in children with and without asthma

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative The objective of this research program is to develop a platform for mechanically triggered molecular release that will enable the acoustically controlled delivery of diverse small molecules under physiological conditions. We will use a multifaceted approach to develop mechanochemically active polymers and systems for coupling focused ultrasound with mechanophore activation that will bridge the gap between polymer mechanochemistry and translational applications in biology and medicine.

PI_NAMEs: ROBB, MAXWELL J (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TITLE: Development of Chemical Platforms for Acoustically Controlled Molecular Delivery


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Narrative: Using in vivo models of myelopoiesis the studies will define the molecular and cellular mechanisms through which different bone marrow vessels control myelo and erythropoiesis. Identification of the mechanisms used by specific vessels to regionally organize the bone marrow, provide spatiotemporal control of HPC differentiation; and the determination of how leukemia perturbs these structures to inhibit normal hematopoiesis is expected to result in the identification of novel targets and strategies for therapeutic intervention

PI_NAMEs: LUCAS, DANIEL  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Acute Myelocytic Leukemia;Adoptive Transfer;Anatomy;Bone Marrow;Cells;Cessation of life;CSF1 gene;CSF3 gene;Cues;cytokine;cytopenia;Data;Dendritic Cells;Development;Discontinuous Capillary;Disease;Distal;DNMT3a;Emergency Situation;Endothelial Cells;Endothelium;Erythroid;Erythropoiesis;experimental analysis;experimental study;Failure;FLT3 gene;FLT3 ligand;granulocyte;Hematopoiesis;Hematopoietic;Homeostasis;Image;In Situ;in vivo;in vivo Model;leukemia;leukemia initiating cell;Location;Macrophage;Macrophage Colony-Stimulating Factor;Manuscripts;Maps;MLL-AF9;Modeling;Molecular;monocyte;mortality;mouse genetics;Mus;Myelogenous;Myeloid Progenitor Cells;Myelopoiesis;neutrophil;Normal Cell;novel;Output;Pathology;Pericytes;Physiology;Production;progenitor;recruit;Reporter;Role;Scheme;segregation;Signal Transduction;single-cell RNA sequencing;Source;spatiotemporal;stem cells;Stress;Structure;Testing;Therapeutic Intervention;tool;transcriptomics

PROJECT_TITLE: Spatial Control of Myeloid Differentiation

STUDY_SECTION: MCH

STUDY_SECTION_NAME: Molecular and Cellular Hematology Study Section[MCH]


NIH_SPENDING_CATS: Microbiome

ORG_CITY: BALTIMORE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Microbial metabolism plays important roles in human health and disease. Our research will investigate a key microbial metabolic enzyme, DXP synthase, toward a long-term goal to understand its function in the human microbiome and its physiological relevance during microbial infection.

PI_NAMEs: FREEL MEYERS, CAREN L. (contact);WOODCOCK III, HENRY LEE

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TITLE: Toward understanding the chemistry and biology of microbial DXP synthase


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Clinical Research;Complementary and Integrative Health;Drug Abuse (NIDA only);Natural Products;Opioids;Pain Research;Substance Misuse

ORG_DEPT: PSYCHIATRY

PHR: Project Narrative Amidst the US opioid crisis, a market emerged for the psychoactive botanical Mitragyna speciosa (kratom), whose alkaloids mitragynine and 7-hydroxymitragynine act as partial biased agonists at mu opioid receptors; kratom is used by millions, possibly tens of millions, of people in the US seeking to self-treat symptoms of chronic pain, psychiatric disorders, and substance use disorders. Yet we know little about the acute or long- term effects of kratom use or discontinuation among US adults, with most data cross-sectional and derived from case reports or from retrospective surveys. The interdisciplinary, interinstitutional K99/R00 studies proposed here will collect and pair ambulatory real-time reports from regular kratom users with samples of the products they used (plus, among a small subsample, biospecimens), and will systematically assess withdrawal symptoms in a monitored setting.

PI_NAMEs: SMITH, KIRSTEN  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Absence of pain sensation;abuse liability;Acute;addiction;Adult;Adverse effects;adverse outcome;Agonist;Alkaloids;Analgesics;Animals;Binding;Biological Assay;Botanicals;Case Study;chronic pain;Clinical;Collaborations;Complex;Consumption;Cross-Sectional Studies;daily functioning;Data;Data Reporting;Diagnosis;Dose;Ecological momentary assessment;Ensure;Equilibrium;Evaluation;Fatigue;Foundations;Future;Goals;Grant;Human;Impairment;In Vitro;Indigenous;Individual;inter-institutional;Intervention Studies;Investigation;Knowledge;Laboratories;Life;Long-Term Effects;Marketing;Mental disorders;Mentors;Methods;Minor;Mitragyna;Monitor;Moods;Motivation;mu opioid receptors;Nausea;non-opioid analgesic;Opiate Addiction;Opioid;opioid epidemic;Opioid Receptor;Opioid Rotation;opioid use disorder;opioid withdrawal;Pain;Pain management;pain symptom;Participant;Patient Self-Report;Pattern;persistent symptom;Personal Satisfaction;Persons;Pharmacology;Plants;Plasma;Policies;pre-clinical;Prevalence;Process;psychiatric symptom;Randomized;Recommendation;Reporting;Research;Research Training;response;Risk;Sampling;Sedation procedure;side effect;social media;Southeastern Asia;Substance Use Disorder;substance use treatment;Surveys;symptom treatment;Symptoms;Therapeutic;Therapeutic Effect;Time;Training;Urine;Vacuum;Withdrawal;Withdrawal Symptom;Work

PROJECT_TITLE: Real-world momentary assessment of kratom use and laboratory-based observed cessation accompanied by product assays: Toward an interdisciplinary characterization of kratom use and pharmacology


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Physical Activity;Prevention

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: This research is relevant to public health because insulin resistance for glucose disposal by skeletal muscle is a required defect in the progression to Type 2 diabetes, and exercise can markedly enhance insulin-stimulated glucose uptake by skeletal muscle. We will focus on the relationship between a protein called AS160 (that regulates glucose uptake) and another protein called the GLUT4 glucose transporter (GLUT4 is the protein that is directly responsible for glucose uptake). This knowledge will advance fundamental understanding of a basic biological outcome, and it has the potential to inform the design of effective exercise protocols and to inspire the creation of new therapies that benefit public health.

PI_NAMEs: CARTEE, GREGORY D. (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Address;adeno-associated viral vector;AGFG1 gene;American;Biological;Blood Glucose;Cell surface;Collaborations;Coupling;Defect;Dependovirus;design;Estrogen Receptors;Event;Exercise;Exocytosis;glucose disposal;Glucose Transporter;glucose uptake;GLUT 4 protein;Goals;Guanosine Triphosphate;Health Benefit;high risk;Human;Hydrolysis;improved;Insulin;insulin regulation;Insulin Resistance;Intracellular Membranes;Knock-out;Knowledge;Link;male;Measures;Mediating;Membrane;Methods;Microscopy;Modeling;Molecular;Muscle;Muscle Cells;Muscle Proteins;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;novel therapeutics;Outcome;Phosphorylation;Physiological;Prediabetes syndrome;prevent;Process;Protein Analysis;protein expression;Proteins;Protocols documentation;Public Health;Rattus;Recommendation;recruit;Regulation;Reporting;Research;Resolution;Rest;Role;Sampling;sedentary;sex;sexual dimorphism;Signal Transduction;Site;Skeletal Muscle;Sorting;Testing;Text;Thinness;Vesicle

PROJECT_TITLE: Regulation of Elevated Postexercise Insulin-stimulated Glucose Uptake by Skeletal Muscle

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative This project focuses on the modeling and incorporation of protein three-dimensional structures across the human proteome to further our ability to describe disease-related protein-protein interaction networks in tissue- and tumor-specific contexts. These structure-informed networks will reveal mechanistic insights regarding cellular processes underlying human diseases ranging from cancer to those resulting from viral and bacterial infection. Our results will also provide hypotheses regarding drugs that can target proteins in these networks.

PI_NAMEs: HONIG, BARRY H (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Address;Algorithms;Area;Bacterial Infections;Biological;Biology;Biomedical Research;Cell Line;Cell Physiology;Cells;Chemicals;Databases;Development;Disease;druggable target;Generations;Genes;Genetic;Genome;genome-wide;genomic data;Goals;Human;human disease;Individual;insight;Link;link protein;machine learning method;Malignant Neoplasms;Maps;Methodology;Methods;Modeling;Molecular;novel;Nucleic Acids;pathogenic bacteria;Patients;Pharmaceutical Preparations;Pharmacotherapy;Protein Analysis;protein function;protein protein interaction;protein structure;protein structure prediction;Proteins;Proteome;Research;Resources;small molecule;software development;Software Tools;structural biology;Structure;Systems Biology;three dimensional structure;Tissues;tool;tumor;Virus;Virus Diseases;Vision;Work

PROJECT_TITLE: Genome-wide structure-based analysis of protein-protein interactions and networks

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Clinical Research;Precision Medicine

ORG_CITY: CHICAGO

ORG_NAME: NATIONAL OPINION RESEARCH CENTER

ORG_STATE: IL

PI_NAMEs: LEINTZ, JEFFREY ;SMITH, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: JAWORSKI, BETH KRISTEN

PROJECT_TERMS: Address;Age;All of Us Research Program;Ancillary Study;Behavior;Characteristics;Chicago;Child;Code;Collaborations;Communication;Communities;Complex;Data;Data Collection;Data Set;design;Disability status;Disclosure;Educational Status;Enrollment;Ensure;Ethnic Origin;experience;flexibility;Future;Gender Identity;Genetic;Geographic Locations;Goals;Health Status;improved;Knowledge;Measures;Methodology;Methods;Monitor;multimodal data;operation;outreach;Participant;participant enrollment;patient engagement;Patient Recruitments;Phase;Physical activity;Population;Population Group;Population Heterogeneity;precision medicine;Process;programs;Protocols documentation;Race;Recording of previous events;recruit;remote assessment;Reporting;Research;Research Design;Research Personnel;research study;Research Support;Secure;Services;Sex Orientation;Socioeconomic Status;success;System;Technical Expertise;Technology;technology platform;Testing;Time;tool;United States National Institutes of Health;Universities;user-friendly;wearable device;Work

PROJECT_TITLE: Partnering for Precision Medicine: A Collaborative Services Center for the All of Us Program


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Congenital Heart Disease;Gene Therapy;Genetics;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: Narrative Long qt syndrome type 2 is a devastative disease that is causing sudden cardiac death (SCD) in young individuals. The studies proposed in this application explore gene therapy for this disease. This novel mode of therapy could revolutionize the treatment of LQT2 and may offer an effective way to prevent SCD reducing the cost and the morbidity associate with this disease.

PI_NAMEs: KOREN, GIDEON  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Action Potentials;Adrenergic Agents;Ants;Arrhythmia;Biochemical;Biological Models;Breeding;Cardiac;Cardiac Myocytes;Cell Physiology;Cells;Characteristics;Chromosome Mapping;CMV promoter;Computer Simulation;cost;Coupling;Cytomegalovirus;Data;density;design;Disease;Dominant-Negative Mutation;Dose;Electric Stimulation;Exhibits;Gene Expression;gene therapy;Gene Transduction Agent;Genes;Genetic;Giant Cells;Goals;Heart;Human;In Vitro;Individual;Injections;Left ventricular structure;Long QT Syndrome;loss of function;Malignant - descriptor;Maps;Masks;Mediating;Modeling;Monitor;Morbidity - disease rate;mosaic;mutant;Mutation;Neonatal;New Zealand;novel;Optics;Oryctolagus cuniculus;Pathogenicity;Pathologic;Phenotype;Population;Potassium;prevent;Reporter Genes;Resistance;sex;small hairpin RNA;Structure of jugular vein;sudden cardiac death;Syndrome;Testing;Time;Tissues;Transgenes;Transgenic Organisms;treatment group;Type 2 Long QT syndrome;Variant;Ventricular Tachycardia

PROJECT_TITLE: Gene therapy for long QT syndrome type 2

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BIRMINGHAM

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Our Collaborative Network for Nurturing Ecosystems of Common Fund Team Science (CONNECT) Integration and Coordination Center (ICC) is dedicated to revolutionizing scientific research and benefiting the Common Fund (CF) programs. By developing comprehensive guidelines, efficient project management, and effective communication, we aim to enhance the impact of CF programs. By gathering stakeholder input, analyzing data, and promoting inclusive practices, we aim to drive breakthrough discoveries based on integrated CF knowledge bases. Our CONNECT ICC will form a robust and efficient framework poised to revolutionize the Common Fund Data Ecosystem (CFDE) and facilitate breakthrough biomedical discoveries, propelling scientific progress and benefiting society.

PI_NAMEs: CHEN, JAKE YUE (contact);DAVIS, SEAN ;GREENE, CASEY S;PING, PEIPEI ;WANG, WEI

PROGRAM_OFFICER_NAME: KANO, KRISTIN KATHLEEN

PROJECT_TERMS: Acceleration;Address;Alabama;Archives;Automobile Driving;base;Biomedical Research;Cataloging;cohesion;Collaborations;Colorado;Communication;Communities;Computer software;dashboard;Data;data dissemination;data ecosystem;data exchange;data management;data repository;data resource;data sharing;Decision Making;Dedications;digital ecosystem;Ecosystem;Effectiveness;Ensure;Environment;Evaluation;evidence base;Feedback;Fostering;Foundations;Funding;Goals;Guidelines;hackathon;improved;Individual;innovation;insight;interoperability;Knowledge;Longevity;meetings;Methodology;Mission;operation;Performance;Practice Management;preservation;Process;process improvement;programs;Protocols documentation;public repository;Reporting;repository;Research;Resources;Role;Science;skills;Societies;System;tool;United States National Institutes of Health;Universities;Update;web app

PROJECT_TITLE: CONNECT: Collaborative Network for Nurturing Ecosystems of Common Fund Team Science

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-L (52)]


PI_NAMEs: CHEN, JAKE YUE (contact)

PROJECT_TERMS: Academia;Accountability;Adopted;Advisory Committees;Alabama;artificial intelligence model;Automobile Driving;Biomedical Research;Bridge to Artificial Intelligence;Cell model;clinical center;Clinical Sciences;cohesion;Collaborations;Communication;Communication Methods;Communication Tools;Communities;community engagement;Community Outreach;Complex;Computer software;Critiques;Data;data dissemination;data ecosystem;data resource;Data Science;Decision Making;Dedications;Development;Ecosystem;empowerment;Ensure;Ethics;Evaluation;Event;Expedite Dissemination;experience;Feedback;Fostering;Funding;Generations;Guidelines;hackathon;Health;improved;Individual;Industry;innovation;International;Internet;Leadership;Location;meetings;member;Mission;multidisciplinary;operation;Outcome;Outcomes Research;Performance;Play;Policies;Process;programs;Protocols documentation;Reporting;Research;Resource Allocation;Resources;Role;Science;Series;social;success;synergism;System;Talents;tool;Training;Transcend;Translational Research;United States National Institutes of Health;Universities;Update;Work


NIH_SPENDING_CATS: Data Science

PI_NAMEs: GREENE, CASEY S (contact)

PROJECT_TERMS: Acceleration;Adopted;Advisory Committees;Annual Reports;Automation;Big Data;Biomedical Research;cohesion;Collaborations;Common Core;Communities;community engagement;Computer software;dashboard;Data;Data Aggregation;Data Collection;Data Coordinating Center;data ecosystem;data integration;data resource;data reuse;design;Development;Ecosystem;Ensure;Evaluation;experience;FAIR principles;Feedback;Fostering;Funding;Goals;Human Resources;improved;informatics tool;insight;Intelligence;Investments;Knowledge;large scale data;Machine Learning;marginalized community;marginalized population;Measures;member;Mission;Outcome;Performance;Process;process improvement;programs;Publishing;Recommendation;Reporting;Resources;response;Science;Site;software development;software systems;Summary Reports;System;tool;Training;United States National Institutes of Health;Update;Work


PI_NAMEs: PING, PEIPEI  (contact)

PROJECT_TERMS: Adopted;Advocate;Budgets;Catalogs;Cloud Computing;cohesion;Collaborations;commercialization;Common Core;Communities;Data;data ecosystem;data management;data repository;data resource;Data Science;Data Set;design;digital;digital ecosystem;Dimensions;E-learning;Ecosystem;Education;Effectiveness;Elements;Ensure;Equipment and supply inventories;equity, diversity, and inclusion;Ethics;Evaluation;Event;experience;FAIR principles;Fostering;Funding;Future;Generations;Guidelines;Hand;Home;improved;Individual;innovation;International;Knowledge;Leadership;learning materials;Link;Location;Mediation;Metadata;Mind;mindfulness;Mission;Monitor;Needs Assessment;operation;outreach;outreach program;Ownership;Participant;Periodicals;Privacy;Process;Production;program dissemination;programs;Protocols documentation;public repository;Recovery;repository;Request for Applications;Research;Research Personnel;Resources;Role;Science;Secure;Security;Software Tools;Source;success;symposium;synergism;timeline;tool;Training;Transcend;United States National Institutes of Health;web app;Work


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Aging;Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Heart Disease;Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: Project Narrative This project will estimate the acute and chronic effects of PR exposure, as measured by PM β-activity and PM γ-activities in a nationwide population-based study and the acute and chronic effects of daily individual radionuclides in four U.S. cities with U.S. Nuclear Weapons Non-Proliferation Treaty sites radionuclides, on cardiovascular disease (CVD) admissions among Medicare enrollees and individual all ages CVD mortality. In three U.S. cities we will also measure PM α-activity associated with short-lived radionuclides using a newly continuous monitor, and we will estimate daily exposures to PM2.5 α-activity from long-lived radionuclides (archived filters) in one city; we will assess the acute effects of these exposures on CVD admissions and mortality, and will identify factors that may determine vulnerability to PR effects on CVD.

PI_NAMEs: KOUTRAKIS, PETROS ;ZANOBETTI, ANTONELLA  (contact)

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: Acute;Address;Admission activity;Age;Air;Air Pollution;anthropogenesis;Archives;Area;Beta Particle;Biological Markers;Blood Pressure;Boston;cancer risk;Cardiovascular Diseases;cardiovascular effects;cardiovascular risk factor;Cardiovascular system;Censuses;Chronic;Cities;Collection;comorbidity;Congestive Heart Failure;cost effective;Data;Dose;Education;Environmental Health;Ethnic Origin;Exposure to;fine particles;Gamma Rays;Gases;Goals;Health;health data;Health Policy;heart function;Hospitalization;Hour;Human body;improved;Individual;Inflammation;Inhalation;Investigation;Ionizing radiation;Knowledge;Link;Long-Term Effects;Los Angeles;Measures;Medicaid eligibility;Medicare;Methods;Modeling;Modification;Monitor;Morbidity - disease rate;mortality;Myocardial Infarction;Nuclear Weapon;Oxidative Stress;particle;Particulate;Particulate Matter;Population;Population Study;Property;prospective;Public Health;pulmonary function;Race;Radiation;Radioactive;Radioactivity;Radioisotopes;Radon;Reporting;Research;response;Risk Factors;Seasons;sex;Site;Socioeconomic Status;Source;spatiotemporal;Stroke;Toxic effect;Treaty;ultrafine particle;United States National Center for Health Statistics;Update;Ventricular Arrhythmia

PROJECT_TITLE: A nationwide population-based study investigating the cardiovascular effects of exposure to particulate matter α-, β-, and γ-activities and individual radionuclides

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


NIH_SPENDING_CATS: Mental Health

PHR: PROJECT NARRATIVE Cardiovascular, immune/inflammatory and psychiatric diseases are highly prevalent, debilitating, and are often linked to dysregulation of glucocorticoid production in the setting of chronic stress. These studies will examine mechanisms that govern growth and function of glucocorticoid-producing cells in the adrenal gland. Such efforts are vital to advance our understanding of HPA axis regulation and for development of therapeutic approaches for the treatment and prevention of chronic stress-related disorders.

PI_NAMEs: HAMMER, GARY D. (contact)

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: Acute;Adrenal Cortex;Adrenal Cortex Hormones;Adrenal gland hypofunction;Adrenal Glands;androgen sensitive;Androgens;biological adaptation to stress;Cardiovascular Diseases;Catabolism;Cell Differentiation process;Cell Physiology;Cells;Chemosensitization;Cholesterol;Chronic;Chronic Disease;Chronic stress;Clinical;Complex;Corticotropin;Data;design;Disease;Down-Regulation;Ecosystem;enhancing factor;Exhibits;Feedback;Female;Future;Genes;Genetic Transcription;Glucocorticoids;Goals;Grant;Growth;Heterogeneity;Homeobox;Hormonal;hypothalamic-pituitary-adrenal axis;Immune System Diseases;Inflammatory;insight;Knowledge;Laboratories;Link;Lipids;Liver;Maintenance;male;Mediating;Mediator;Mental disorders;Metabolic;Molecular;Mus;Neurosecretory Systems;novel;NR0B1 gene;Output;Pancreas;Pathway interactions;Patients;Physiological;Population;Prevalence;Prevention;Prevention strategy;Process;Production;programs;Regulation;Research;Role;sex;Sex Differences;Signal Pathway;Specific qualifier value;Sterols;Stress;stress related disorder;stressor;Therapeutic;therapeutic development;tissue regeneration;Tissues;transcription factor;treatment strategy;women versus men;Zona Fasciculata

PROJECT_TITLE: Mechanisms of Adrenal Differentiation

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Dissemination and Implementation Research;Hearing Loss;Prevention;Rehabilitation

ORG_CITY: Chicago

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: Project Narrative Over-the-Counter (OTC) hearing aids were recently made available for purchase in October 2022, and are intended to improve both the access and cost of hearing aids. Unfortunately, the OTC hearing aid product information label (required for candidacy determination) is both suboptimal in design and ineffective, rendering critical health information unusable by the average consumer. The purpose of this proposal is to develop an mHealth decision aid (HearEase) to help guide consumers through the candidacy process for an OTC hearing aid.

PI_NAMEs: SINGH, JASLEEN  (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: 18 year old;Accelerated Phase;Acceleration;Address;Adopted;Adoption;Adult;Affect;Algorithms;American;Chronic;Communication Tools;Complex;Comprehension;cost;Decision Aid;design;Development;Devices;Educational workshop;Effectiveness;Ensure;expectation;Feedback;Focus Groups;Goals;Health;Health Expenditures;Health Personnel;Health Technology;Healthcare;Hearing;Hearing Aids;hearing impairment;Hybrids;implementation framework;implementation strategy;improved;Individual;iterative design;Label;Manufacturer;Methods;mHealth;Modeling;Modernization;National Institute on Deafness and Other Communication Disorders;Persons;Phase;Process;prototype;Research;Safety;Sales;Self Determination;Services;Social Environment;Structure;success;Surveys;Symptoms;Target Populations;Technology;Testing;Time;tool;tool development;treatment adherence;Trust;United States;United States Food and Drug Administration;uptake;usability;user centered design;Work

PROJECT_TITLE: HearEase: A Candidacy Tool for Over-the-Counter Hearing Aids

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Rural Health;Skin Cancer;Social Determinants of Health

ORG_CITY: SALT LAKE CITY

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Children residing in rural and underserved areas of the US are at high risk for skin cancer over the lifecourse and require early intervention for sun safety programming in settings with intense ultraviolet radiation exposure levels from the sun. We will test a new skin cancer prevention program for young children living in these communities that is delivered through youth sports leagues. This project will increase our understanding of how to deliver health behavior interventions in community recreational settings with rural and underserved populations.

PI_NAMEs: TERCYAK, KENNETH ;WU, YELENA PING (contact)

PROGRAM_OFFICER_NAME: PERNA, FRANK

PROJECT_TERMS: Address;Adopted;Adoption;Adult;Affect;Age;American;Area;arm;Automobile Driving;Awareness;Behavior;behavior change;Behavior Therapy;Behavioral;Behavioral Model;Biological;Cancer Burden;Cancer Control;cancer education;cancer health disparity;cancer prevention;Cells;Child;Child Behavior;Child Health;Childhood;climate change;Cluster randomized trial;Cognition;Communities;community engaged approach;Community Outreach;community partnership;community-centered;community-level factor;Country;County;Data;deprivation;design;Development;Dimensions;Disadvantaged;Disparity;Early Intervention;Education;efficacy evaluation;efficacy testing;Enrollment;environmental adaptation;Evaluation;evidence base;experience;Exposure to;Female;Future;Goals;Guidelines;Health behavior;health disparity;high risk;improved;Incidence;Individual;Instruction;Intervention;intervention delivery;Knowledge;Life Cycle Stages;Life Style;Location;Longterm Follow-up;male;Malignant Neoplasms;Manufactured Baseball;Mediating;Medical;Melanoma;Modeling;mortality;Nursery Schools;Outcome;Parents;peer;Persons;Play;Policies;prevent;Prevention;Prevention approach;Prevention education;Prevention program;primary outcome;Process;process evaluation;programs;Psychological reinforcement;Public Health;Radiation Protection;Randomized;Recommendation;Recreation;Reporting;Research;Resources;response;Risk;Rural;rural area;Rural Community;Rural Population;rural underserved;rurality;scale up;Scanning;School-Age Population;Schools;Seasons;secondary endpoint;Self Efficacy;Shapes;Skin;Skin Cancer;skin cancer prevention;social;Sports;Structure;sun protection;sun safety;Sunburn;Sunscreening Agents;Testing;the sun;theories;Time;tool;Training;Ultraviolet Rays;underserved area;underserved community;Underserved Population;uptake;urban setting;US State;UV Radiation Exposure;Youth;youth sports

PROJECT_TITLE: Multilevel RCT of Rural Community Sun Safety for Young Children in Sports

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Nutrition;Prevention

ORG_CITY: TAMPA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Project narrative Clostridioides difficile is the leading cause of nosocomial infection and is classified as ‘urgent threat’ by the Centers for Disease Control and Prevention (CDC). We propose to generate a class of non-antibiotics-based and probiotics-delivered therapeutics specifically targeting and killing C. difficile in the intestine where C. difficile colonizes. We expect that these novel therapeutic agents will address the very-high rates of recurrent C. difficile infection.

PI_NAMEs: SUN, XINGMIN  (contact);ZHANG, YONGRONG

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Anaerobic Bacteria;Animal Model;anti-toxin;Antibiotic Resistance;Antibiotic Therapy;antibiotic-associated diarrhea;Antibiotics;Antibodies;bactericide;Bacteriophages;Biological Response Modifier Therapy;Caspase;Catalytic Domain;Centers for Disease Control and Prevention (U.S.);Cessation of life;Chimeric Proteins;Classification;Clinical;Clostridium difficile;Collection;commercialization;Cytolysis;Data;Development;diarrheal disease;dietary supplements;dysbiosis;Engineered Probiotics;Engineering;Epidemic;Etiology;experience;Foundations;gastrointestinal;Gastrointestinal tract structure;Genetic;Growth;gut microbiome;gut microbiota;Hamsters;Health;Hospitalization;Human;Immunotherapy;Infection;innovation;Intestines;Lactococcus lactis;Lead;Licensing;Life;lysin;Lytic;meter;Metronidazole;Modeling;Mus;Nosocomial Infections;novel;novel therapeutics;nutrition;Oral Administration;Pathogenesis;Pharmaceutical Preparations;Play;Predisposition;prevent;Prevention;Probiotics;Proteins;Pseudomembranous Colitis;Publishing;Recombinants;Recurrence;Reporting;Reproduction spores;Research;Research Personnel;Resistance;Ribotypes;Role;Saccharomyces;Site;sound;Specificity;standard care;Surface;System;targeted treatment;Testing;Therapeutic;Therapeutic Agents;Toxin;Treatment Efficacy;United States Food and Drug Administration;vaccine development;Vancomycin;Work

PROJECT_TITLE: Development of probiotic-based and Clostridioides difficile-targeted therapeutics

STUDY_SECTION: DMPA

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology A Study Section [DMPA]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences;Pediatric

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: NARRATIVE We recently concluded and published the results of a large phase 2 trial of 16-week treatment with the Alzheimer’s disease drug memantine (the follow-up memantine trial) in which we investigated the safety and efficacy of this drug on memory, thinking, and adaptive test results in adolescents and young adults with Down syndrome. In addition, the trial protocol also included collection of evoked electroencephalographic (EEG) data before and after memantine treatment and measurement of plasma biomarkers of Alzheimer’s disease at the final visit of the study. Here, we propose to perform analyses on the relationships between scores in the various neuropsychological tests and the EEG and Alzheimer’s disease biomarker assessments and to share the de-identified data with the community via the NIH-funded INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project through the INCLUDE Data Coordinating Center (DCC).

PI_NAMEs: COSTA, ALBERTO C S (contact)

PROGRAM_OFFICER_NAME: RYAN, LAURIE M

PROJECT_TERMS: Adolescent and Young Adult;aged;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer’s disease biomarker;Auditory;Auditory Brainstem Responses;Biological Markers;Brazil;Chromosome 21;Clinical;Clinical Data;Clinical Trials;Cognitive;cognitive enhancement;cognitive function;cohort;Collection;Communities;Consultations;Data;Data Analyses;Data Collection;Data Coordinating Center;data de-identification;data exchange;Data Set;data sharing;Databases;Dedications;Dementia;density;Development;Dose;Down's Syndrome;drug efficacy;Early Onset Alzheimer Disease;Electroencephalography;Electrophysiology (science);Eligibility Determination;EP300 gene;Evoked Potentials;experience;experimental study;follow-up;Follow-Up Studies;Funding;Goals;Health;Health Insurance Portability and Accountability Act;Hearing Tests;improved;improved outcome;Individual;insight;Intellectual functioning disability;Intervention;Investigation;life span;Measurement;Measures;Medical;Memantine;member;Memory;Nerve Degeneration;Neurocognitive;neurophysiology;Neuropsychological Tests;Neuropsychology;Ohio;Participant;Pathology;Persons;Pharmaceutical Preparations;pharmacologic;phase II trial;Phenotype;phenotypic data;Placebos;Plasma;Protocols documentation;Public Health;Publishing;Randomized;recruit;Regression Analysis;Research;Safety;Site;System;Test Result;Testing;Thinking;Unbalanced Translocation;United States National Institutes of Health;Visit;Work

PROJECT_TITLE: Down Syndrome Memantine Follow-up Study: EEG Data Analysis and Data Sharing with the Research Community

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-B (56)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Cannabinoid Research;Clinical Research;Depression;Endocannabinoid System Research;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness;Suicide

ORG_CITY: MONTREAL

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: CENTRE DE RECHERCHE DE L'HOPITAL DOUGLAS

ORG_STATE: PQ

ORG_ZIPCODE: H4H 1R3

PHR: Project Narrative This project aims to examine the levels of the endocannabinoid rate limiting enzyme Fatty Acid Amide Hydrolase (FAAH) in young people with depression with and without suicidal behaviours, in comparison with healthy individuals (specific Aim 1). This project will provide first in vivo evidence for altered FAAH in MDD and suicide attempts, hence may help in developing new classes of therapies for young populations targeting the endocannabinoid system. This study will also explore –for the first time- the role of in vivo brain FAAH in behavior and stress/trauma measures/ trait impulsivity/aggression and anandamide levels in these clinical populations (exploratory aims). Sex will be investigated as a primary aim (Specific Aim 2). We hope this study will provide novel treatment targets to treat MDD and perhaps prevent suicide in young people.

PI_NAMEs: MIZRAHI, ROMINA  (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Adolescence;Age;Aggressive behavior;anandamide;Anterior;Anxiety;arterial spin labeling;Autopsy;Behavior;Binding;Blood;Brain;Brain imaging;Cannabis;Cause of Death;Cerebrovascular Circulation;Chronic stress;cingulate cortex;Clinical;Clinical Data;clinical infrastructure;cohort;Complex;Data;depressed patient;dosimetry;Emergency medical service;endocannabinoid signaling;Endocannabinoids;endogenous cannabinoid system;endophenotype;Environment;Enzymes;Epidemiology;Event;Exhibits;experience;FAAH inhibitor;fatty acid amide hydrolase;Female;Functional disorder;Future;Gatekeeping;General Population;Guilt;healthy volunteer;Hospitals;Human;Image;imaging study;Impulsivity;in vivo;indexing;Individual;Infrastructure;Intervention;Kinetics;Life;life history;Link;Magnetic Resonance Imaging;Major Depressive Disorder;male;Maps;marijuana use;Measures;men;Mental Depression;Metabolism;Modeling;Molecular;Molecular Target;mood symptom;Neurobiology;neurotransmitter release;neurotransmitter reuptake;new therapeutic target;novel;pediatric trauma;Peripheral;Persons;Pharmacology Study;Phenotype;Physiological;Play;Population;Positron-Emission Tomography;Prefrontal Cortex;Prevention;Property;protein expression;Publishing;radiotracer;recruit;Regulation;Reporting;Reproducibility;Research;Resolution;response;Rodent;Role;Safety;Scanning;sex;Site;Specificity;Stress;suicidal behavior;Suicide;Suicide attempt;suicide attempter;Suicide prevention;synaptic inhibition;Target Populations;Therapeutic Intervention;Time;Tissues;trait;trait impulsivity;Trauma;uptake;usability;Validation;Vulnerable Populations;Woman;Work;young adult;Youth

PROJECT_TITLE: Imaging Alterations in Endocannabinoid Metabolism in Depression and Suicide

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Lung;Nanotechnology;Pneumonia and Influenza

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: SARS-CoV-2 is a main worldwide threat with more than >15,000,000 global deaths. There are currently only a few therapeutic treatments available. Thus, it is of the utmost importance to identify novel therapeutic approaches to eliminate SARS-CoV-2.

PI_NAMEs: GALLAY, PHILIPPE ANDRE (contact)

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 2019-nCoV;ACE2;Aerosols;Animals;anti-viral efficacy;Apoptosis;Apoptotic;biodegradable polymer;Bioluminescence;cell killing;Cell Membrane Permeability;Cells;Cellular Membrane;Cessation of life;Clinical Trials;co-infection;COVID-19;COVID-19 mortality;COVID-19 treatment;COVID-19 vaccine;cytokine;Dengue;design;Developed Countries;Development;diphtheria toxin fragment A;DNA;DNA Fragmentation;Drug Delivery Systems;Ebola;Esters;Event;Evolution;experimental study;Exposure to;Fluorescence;Genes;Genetic Transcription;Goals;Hamsters;Health;Hepatitis B Virus;Human;Image;Immune Targeting;In Vitro;in vivo;in vivo fluorescence imaging;in vivo imaging;Infection;Inflammatory Response;Influenza;Influenza A virus;Influenza B Virus;influenzavirus;Inhalation;Inhalators;innovation;interest;Interstitial Pneumonia;Intranasal Administration;Lassa;Lesion;lipid nanoparticle;low income country;Lung;lung development;Lung infections;lung injury;lung lesion;Macrophage;Maps;Mediating;Mesocricetus auratus;Methods;Modeling;Mus;Mutation;nanoformulation;nanoparticle delivery;Nebulizer;Nose;novel;novel strategies;novel therapeutic intervention;nucleic acid-based therapeutics;Open Reading Frames;optimism;pandemic disease;Patients;Persons;Phagocytosis;Phenotype;Polymerase;preservation;prevent;Proteins;pulmonary function;Resolution;Respiratory System;respiratory virus;RNA;Route;Safety;SARS-CoV-2 exposure;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;single-cell RNA sequencing;Solid;Specificity;System;systemic toxicity;Testing;Therapeutic;tool;Toxic effect;transcriptome sequencing;Transfer RNA;Transgenic Mice;Treatment Efficacy;vaccine access;vaccine hesitancy;Vaccines;vector;Viral;Viral Load result;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: A NOVEL STRATEGY TO INHIBIT SARS-COV-2 INFECTION AND COVID-19


ORG_DEPT: SURGERY

PHR: NARRATIVE The goal of this application is to improve the durability of Bioprosthetic Heart Valves thus reducing the need for multiple cardiac re-operations in patients with advanced Metabolic Syndrome. Our lab discovered this cohort of patients has an enhanced accumulation of pro-calcific, pro-oxidation, and pro-glycation markers resulting from their altered blood biochemistry. Since we have discovered that POZ reduces calcification and SVD using MetS sera incubation assays and MetS animal model, here we propose to identify the main driving factors responsible for the accelerated structural degeneration and calcification of implantable materials in patients with MetS and to assess POZ as MetS-specific mitigation strategy

PI_NAMEs: FERRARI, GIOVANNI  (contact);LEVY, ROBERT J

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: absorption;Acceleration;Adolescent;Animal Model;Animals;Architecture;Automobile Driving;biobank;Biochemical;Biochemistry;Biocompatible Materials;Biological Assay;Biomechanics;Bioprosthesis device;Blood;blood pressure control;calcification;Cardiac;Cardiovascular Diseases;cardiovascular risk factor;Caring;Cattle;Chemicals;Cholesterol;Circulation;Clinical;Clinical Data;cohort;Collagen;Combined Modality Therapy;comorbidity;crosslink;Crosslinker;density;Devices;diabetic;differential expression;Differential Scanning Calorimetry;Education;Engineering;Exhibits;experimental study;Exposure to;Extracellular Matrix;Glutaral;glycation;Goals;Heart;Heart Valve Diseases;Heart Valves;High Density Lipoprotein Cholesterol;Human;Hyperglycemia;Hypertriglyceridemia;immune activation;Immunohistochemistry;Implant;implant material;implantable device;improved;In Vitro;in vivo;Incubated;Infiltration;interest;Intervention;Laboratories;Medication Management;Metabolic syndrome;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Operative Surgical Procedures;Organ;Outcome;oxidation;Patients;pericardial sac;Periodicity;pharmacologic;Pharmacological Treatment;Phenotype;Physiologic pulse;Physiological;Predisposition;preservation;pressure;profiles in patients;programs;Proteins;Proteomics;Publishing;Rattus;Repeat Surgery;Reporting;Research Project Grants;Risk;Rodent Model;Role;Scanning Electron Microscopy;second harmonic;Serum;Serum Proteins;Sheep;Structure;subcutaneous;Survival Rate;System;Systemic hypertension;Testing;Thinness;Tissues;Xenograft procedure

PROJECT_TITLE: Mitigation Strategies for Metabolic Syndrome-induced Bioprosthetic Heart Valve Degeneration

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: JOHNSON CITY

ORG_NAME: EAST TENNESSEE STATE UNIVERSITY

ORG_STATE: TN

PHR: NARRATIVE Patients with HBV infection are subject to prolonged (often lifelong) treatment due to the lack of curative therapeutics. Thus, multimodal, robust therapeutic strategies are urgently needed to eliminate HBV cccDNA, which sustains viral replication and is refractory to the current antiviral regimens. Recently, we have designed and selected the most specific and potent gRNA/Cas9 HBV gene-editing drugs using HBV cellular models. We have also developed an exosome-based drug delivery system that can specifically deliver these synthetic gRNA/Cas9 RNP drugs to human hepatocytes. In this proposal, we will evaluate the antiviral efficacy and any potential off-target effects of these dual specific HBV gene-editing drugs, both in vitro and in vivo. The objective of this project is to lay the foundation for future clinical studies to achieve our long-term goal of curing chronic HBV infection. If successful, this novel drug design and delivery platform may be utilized to combat existing and emerging viral diseases. It is thus clinically significant, timely, and relevant to public health.

PI_NAMEs: YAO, ZHI Q. (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: Address;analog;Animal Model;Animals;anti-viral efficacy;Binding;Biodistribution;Biogenesis;Biological;biomaterial compatibility;biophysical properties;Biophysics;Cell model;Cells;Chronic Hepatitis B;Circular DNA;Clinical;Clinical Research;clinically significant;Clustered Regularly Interspaced Short Palindromic Repeats;combat;curative treatments;cytotoxic;cytotoxicity;design;DNA;DNA biosynthesis;Drug Delivery Systems;Drug Design;drug release kinetics;Drug Targeting;Drug usage;engineered exosomes;Engineering;Exhibits;exosome;Face;Foundations;Future;gene therapy;Genes;Goals;Guide RNA;Half-Life;Hepatitis B Infection;Hepatitis B Vaccination;Hepatitis B Virus;Hepatocyte;HepG2;Human;humanized mouse;Immune response;immunogenicity;improved;In Vitro;in vivo;innovation;insertion/deletion mutation;Insertional Mutagenesis;intravenous administration;Kinetics;Life Cycle Stages;Liver;Mediating;Medical;multimodality;Mus;Na(+)-taurocholate-cotransporting peptide;novel;novel therapeutics;Patients;Peptides;Pharmaceutical Preparations;Plasmids;Production;Property;Proteins;Public Health;Readiness;Refractory;Regimen;Ribonucleoproteins;Risk;Safety;Series;Side;side effect;Site;Specificity;Surface;System;Technology;Testing;Therapeutic;Tissues;trafficking;Transcript;translational study;United States;uptake;Viral;viral DNA;Viral Physiology;Viral Vector;Virus Diseases;Virus Receptors;Virus Replication

PROJECT_TITLE: Engineered exosomes carrying synthetic gRNA/Cas9 targeting HBV-infected cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-M (03)]


NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Household Energy Combustion;Health Effects of Indoor Air Pollution;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE Cooking using biomass is ubiquitous, and the burdens of fuel collection and household air pollution exposure impose heavy physical, social, economic, and environmental costs on the vulnerable (including women and children), while contributing to climate change. We will design, refine, and test the effectiveness of implementation strategies to promote purchase and use of electric induction stoves – arguably the cleanest household cooking solution – among low-income households in peri-urban Cambodia. Our goal is to provide actionable strategies to achieve equitable, sustainable access to and use of induction stoves that are transferable to other cooking technologies and to other low-resource setting seeking to advance health, gender equity, and climate goals through implementation of clean cooking solutions.

PI_NAMEs: FREEMAN, MATTHEW C (contact);PILLARISETTI, AJAY

PROGRAM_OFFICER_NAME: O'FALLON, LIAM

PROJECT_TERMS: Acceleration;Achievement;Adherence;Adoption;adverse birth outcomes;Air Pollution;Animals;Area;arm;Behavior;Biomass;biomass fuel;Cambodia;Cardiovascular Diseases;Cessation of life;Characteristics;Charcoal;Child;Climate;climate change;climate-related health;Cluster randomized trial;Coal;Collaborations;Collection;cooking;Cookstove;cost;cost estimate;Cost Measures;Country;design;Diabetes Mellitus;disability;Disproportionately impacts women;Dose;Economics;Education;Educational workshop;Effectiveness;effectiveness evaluation;effectiveness outcome;effectiveness testing;Electricity;Environmental Risk Factor;Equity;evidence base;Exposure to;fine particles;Fire - disasters;Fossil Fuels;Gases;gender equity;Goals;Guidelines;Health;Health Benefit;Household;Household Air Pollution;hybrid type 2 trial;Hybrids;implementation cost;implementation evaluation;implementation outcomes;implementation research;implementation science;implementation strategy;implementation tool;improved;Incentives;Income;incremental cost-effectiveness;Intervention;intervention delivery;intervention refinement;Kidney Diseases;low and middle-income countries;Low income;Maintenance;Malignant Neoplasms;Maps;Measurement;Measures;meetings;Methods;Modeling;Mothers;Motivation;novel;Outcome;Participant;peri-urban;Persons;Petroleum;Policies;pollutant;Pollution;premature;primary outcome;programs;prototype;Public Sector;Random Allocation;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reproducibility;Research;Research Methodology;Residual state;Resource-limited setting;Respiratory Disease;Sales;scale up;social;Southeastern Asia;Technology;Testing;theories;Time;Translating;underserved community;uptake;welfare;Woman;Wood material;World Health Organization

PROJECT_TITLE: Applied Implementation Research for Clean Cooking in Cambodia (AIR-C3): equity, exposure, costs, and benefits of induction stove interventions

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE In this project we will develop novel statistical methodology and software to address major limitations of current Mendelian Randomization methods and gene-environment and gene-gene interaction methods with the application to large genomics data and Biobank data, including UK Biobank, NHLBI TOPMed and All of US. The proposed novel methodology and their applications to genomic data would speed up the new discoveries and improve our understanding of genetic architecture of complex traits, which aligns with the NHGRI mission.

PI_NAMEs: ZHU, XIAOFENG  (contact)

PROGRAM_OFFICER_NAME: ZHANG, LI

PROJECT_TERMS: Address;Alcohol consumption;Alzheimer's Disease;Architecture;biobank;Biological;Blood Pressure;Cardiovascular system;causal variant;cigarette smoking;Clinical Trials;Complex;Computer software;Consumption;cost;cost efficient;Data;Data Analyses;Data Set;design;Development;Disease;disorder risk;drug repurposing;Environment;Environmental Risk Factor;epidemiology study;Etiology;experimental study;gene environment interaction;gene interaction;gene network;Genes;Genetic;genetic architecture;genetic variant;Genetic Variation;Genome;genome sequencing;genome wide association study;genome-wide;genome-wide analysis;genomic data;Genomics;Goals;improved;insight;instrument;Linear Regressions;Linkage Disequilibrium;Mendelian randomization;Methodology;Methods;Mission;National Heart, Lung, and Blood Institute;National Human Genome Research Institute;novel;Obesity;Observational epidemiology;Outcome;Physical activity;Physical Education;pleiotropism;polygenic risk score;programs;Prospective Studies;Pythons;Research Institute;Research Personnel;Risk Factors;Sampling;simulation;Sleep;Sleep Disorders;Software Tools;Source;Speed;Statistical Data Interpretation;Statistical Methods;statistics;Testing;Time;trait;Trans-Omics for Precision Medicine;user-friendly;web site;whole genome

PROJECT_TITLE: Statistical Analysis of Large Genomic Data Sets

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project narrative Medications for opioid use disorder save lives. However, access to these evidence-based treatments has been uneven across racial and ethnic groups. We examine the role of place, providers, plans and policy in the equitable use of medications for opioid use disorder among Medicaid enrollees using a network of university partnerships with Medicaid agencies in eleven states.

PI_NAMEs: DONOHUE, JULIE MARIE (contact)

PROGRAM_OFFICER_NAME: HAEGERICH, TAMARA

PROJECT_TERMS: access disparities;Address;Adopted;Adult;Atlases;Automobile Driving;Benchmarking;Black Populations;Buprenorphine;Caring;Classification;Contracts;COVID-19 pandemic;Criminal Justice;Data;data imputation;Data Linkages;data quality;Data Sources;Death Rate;Dimensions;Disparity;dosage;Dose;Education;Environment;Equity;ethnic disparity;Ethnic equity;ethnic identity;ethnic minority population;Ethnic Origin;Ethnic Population;evidence base;Evidence based treatment;financial incentive;Formulation;Funding;Geography;Health;Healthcare;Hispanic Populations;Home;Hospitals;Housing;improved;improved outcome;Incentives;Individual;Inequity;information classification;Infrastructure;Insurance Carriers;Investments;Knowledge;Learning;Link;Louisiana;Low income;Managed Care;Managed Care Programs;marginalization;Measurement;Measures;Medicaid;medication for opioid use disorder;member;Methadone;Methodology;Methods;Minority;Mississippi;model design;Modeling;mortality;Motivation;multilevel analysis;National Institute of Drug Abuse;novel;opioid epidemic;opioid use disorder;Outcome;outcome disparities;Outcome Study;overdose death;overdose prevention;Parents;patient oriented;Patient-Focused Outcomes;Performance;Pharmaceutical Preparations;Policies;Policy Developments;Policy Maker;Population;Positioning Attribute;prevention service;prior authorization;programs;Provider;provider networks;Race;racial disparity;Racial Equity;racial identity;racial minority population;racial population;Recovery;Regulation;Relaxation;Research;Research Personnel;Role;Services;sex;Single-Payer System;Social Work;Source;Structural Racism;System;Techniques;Tennessee;tool;treatment services;Universities;US State;Vital Statistics;Work

PROJECT_TITLE: Improving racial equity in opioid use disorder treatment in Medicaid

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Electronic Nicotine Delivery Systems;Harm Reduction for Substance Misuse;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT SUMMARY The average smoker attempts to quit smoking at least 30 times before succeeding. These attempts typically occur over decades of smoking, carcinogen and toxicant exposure. Novel alternatives must be considered to reduce the combustible cigarette-attributable morbidity and mortality among smokers unable to quit with traditional approaches.

PI_NAMEs: AUDRAIN-MCGOVERN, JANET E (contact)

PROGRAM_OFFICER_NAME: RODITIS, MARIA LEIA

PROJECT_TERMS: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol;Adult;Affect;Alternative Nicotine Delivery Systems;Behavior;Behavioral;Biochemical;Biological Markers;Carbon Monoxide;Carcinogen exposure;Cessation of life;Chemicals;Cigarette;cigarette smoke;Cigarette Smoker;cigarette smoking;Collection;combustible cigarette;craving;Data;Electronic cigarette;electronic cigarette use;Electronic Nicotine Delivery Systems;follow-up;Fostering;Harm Reduction;Health;improved;Industry;Inhalation;interest;Investigation;Laboratories;Measures;Morbidity - disease rate;mortality;negative affect;Nicotine;Nitrosamines;non-cigarette tobacco product;novel;Oral;Outcome Measure;Participant;Pharmaceutical Preparations;Phase;primary outcome;prolonged abstinence;prospective;Protocols documentation;Psychological reinforcement;pulmonary function;Randomized;Regimen;Reporting;Research;Rewards;Route;secondary endpoint;secondary outcome;Smoker;Smoking;smoking abstinence;smoking cessation;smoking exposure;Spirometry;success;Surgeon;Symptoms;Tobacco;tool;Toxicant exposure;Visit;Withdrawal

PROJECT_TITLE: Alternative Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Human Genome;Liver Disease;Nutrition

PHR: Project Narrative Thyroid hormone (TH) uses nuclear receptors (NRs) and NR corepressors (NCORs) to regulate all aspects of metabolism, especially in the liver where non-alcoholic steatotic hepatitis (NASH) in the setting of obesity and diabetes can be life threatening. We have uncovered novel aspects of how TH and NCORs regulate metabolism in the liver, and our studies will provide new insights into how normal metabolic physiology is regulated, and how TH alleviates NASH. This work is critical to understand and combat the metabolic abnormalities contributing to the epidemics of diabetes, obesity, and metabolic liver disease in the United States and worldwide.

PI_NAMEs: LAZAR, MITCHELL A. (contact)

PROGRAM_OFFICER_NAME: BURCH, HENRY B

PROJECT_TERMS: Active Sites;Address;Agonist;Anti-Inflammatory Agents;ATAC-seq;Biological;ChIP-seq;Chromatin;Clinic;Clinical;combat;Complex;CRISPR/Cas technology;Data;Deacetylase;derepression;Development;Diabetes Mellitus;Energy Metabolism;Enzymes;Epidemic;epigenomics;Epitopes;Failure;Fasting;Fatty Liver;feeding;Fibrosis;Functional disorder;functional genomics;Gene Expression;Genes;genetic corepressor;Genetic Transcription;Genomic approach;Genomic Segment;global run on sequencing;Gluconeogenesis;Goals;HDAC3 gene;Hepatitis;Histone Deacetylase Inhibitor;Hormone Responsive;Hormone use;Hyperthyroidism;improved;Inflammation;innovation;insight;Knock-in;Knock-out;Kynurenine;Label;Laboratories;Learning;Life;lipid biosynthesis;lipid metabolism;Liver;Liver diseases;liver metabolism;Lysine;Mediating;Mediator;Metabolic;metabolic abnormality assessment;Metabolic Diseases;Metabolism;metabolomics;Molecular;mouse model;Multiprotein Complexes;Mus;mutant;NCOR1 gene;NCOR2 gene;non-alcoholic;nonalcoholic steatohepatitis;novel;Nuclear Hormone Receptors;Nuclear Receptors;Obesity;Pathway interactions;Patients;Pharmaceutical Preparations;Phenocopy;Physiological;Physiology;prevent;Proteins;Proteomics;recruit;Regulation;Repression;response;Role;small hairpin RNA;Testing;Thyroid Hormone Receptor;Thyroid Hormones;Transcription Repressor;transcriptomics;Tryptophan;Tryptophan Metabolism Pathway;United States;Work

PROJECT_TITLE: Integrative Physiology of Thyroid Hormone Receptors and Nuclear Receptor Corepressors


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Behavioral and Social Science;Chronic Pain;Clinical Research;Dissemination and Implementation Research;Health Services;Osteoarthritis;Pain Research;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Telehealth

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: This project is a planning period to prepare for a randomized clinical trial of a Stepped Exercise Program for Knee Osteoarthritis (STEP-KOA). STEP-KOA is a patient-centered an efficient model to help health systems incorporate exercise-based therapies, which are core but under-utilized components of care for knee osteoarthritis. The ultimate goal of the trial is to improve pain, function and other important outcomes for individuals with knee osteoarthritis.

PI_NAMEs: ALLEN, KELLI D. (contact);GOLIGHTLY, YVONNE M

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Address;Adult;arthritis education;Behavioral;Budgets;Caring;Clinic;Clinical;clinical care;Clinical Trials;clinically relevant;Control Groups;cost effective;cost effectiveness;Data;data management;Databases;disability;effectiveness-implementation RCT;Enrollment;Ensure;evidence base;Exercise;exercise prescription;exercise program;Exercise Therapy;functional decline;future implementation;Goals;Health system;Healthcare Systems;Home;Hybrids;implementation barriers;implementation efforts;implementation/effectiveness;improved;Individual;Intervention;Knee;Knee Osteoarthritis;lifetime risk;Maintenance;Manuals;Modeling;Monitor;Outcome;Pain;Participant;Pathway interactions;patient oriented;Patient Self-Report;Patients;Physical activity;Physical Function;physical therapist;Physical therapy;Prevalence;Procedures;Process;Protocols documentation;Randomized;randomized, clinical trials;Randomized, Controlled Trials;recruit;Resources;response;Scheme;Site;Statistical Data Interpretation;telehealth;telephone coaching;Testing;timeline;tool;Training;treatment as usual;treatment guidelines;trial planning;Veterans Health Administration;Visit;Waiting Lists

PROJECT_TITLE: STepped Exercise Program for Knee Osteoarthritis: The STEP-KOA Study

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Immunotherapy;Lung;Lung Cancer;Radiation Oncology

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE The success of chimeric antigen receptor (CAR) T-cell immunotherapy in patients with solid tumors requires effective tumor infiltration, efficient cytotoxicity, and functional persistence. Herein, we propose to promote solid tumor infiltration of CAR T cells by administering tumor-targeted, low-dose radiation as preconditioning therapy and augment anti-tumor efficacy by use of third-generation CAR T cells with KITv co-stimulatory domain.

PI_NAMEs: ADUSUMILLI, PRASAD S. (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Address;anti-PD-1;Antigen Targeting;Antigens;Behavior Therapy;Bronchopulmonary Sequestration;C-KIT Mutation;CAR T cell therapy;CD28 gene;Cell Physiology;Cell Therapy;Cells;chemokine;Chemotaxis;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clinical Trials;cytotoxicity;Data;Dominant Negative Receptor;Dose;Environment;exhaust;exhaustion;Foundations;Generations;Hematologic Neoplasms;Image;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;immunoregulation;Immunosuppression;Immunosuppressive Agents;Immunotherapy;Infiltration;Infusion procedures;Interferon Type II;kinase inhibitor;Literature;Low Dose Radiation;Macrophage;Malignant Neoplasms;malignant pleura tumor;Malignant Pleural Effusion;Malignant Pleural Mesothelioma;Mediating;mesothelin;Modeling;Mutation;neoplastic cell;next generation;overexpression;Pathway interactions;Patients;peripheral blood;Phase;phase 1 study;Phase I/II Trial;pre-clinical;preconditioning;Process;programmed cell death ligand 1;programmed cell death protein 1;Proliferating;Radiation therapy;Regimen;Resistance;response;response biomarker;Safety;Signal Transduction;Solid Neoplasm;Stress;success;T-Cell Proliferation;T-Lymphocyte;Toxic effect;Transforming Growth Factor beta;Translating;translational approach;triple-negative invasive breast carcinoma;tumor;tumor microenvironment;Tumor Promotion

PROJECT_TITLE: CD28-KITv CAR T cells with PD-1 dominant negative receptor

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-U (J2)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Project Narrative: Disparities in high sugary drink consumption persist in US rural regions and among low socioeconomic families. Reducing sugary drinks is a clear cancer-related primary prevention strategy in rural regions and early childhood is a critical period for intervening on sugary drink consumption. The long-term goal of this primary prevention research project is to develop an efficacious sugary drink reduction intervention that has the potential for high reach among rural, low socioeconomic, preschool-aged children ages 2-5 and their parents. Likewise, these research efforts focus on a highly scalable digital health intervention that has heightened potential to be implemented and sustained across rural Head Start centers.

PI_NAMEs: ZOELLNER, JAMIE  (contact)

PROGRAM_OFFICER_NAME: AGURS-COLLINS, TANYA

PROJECT_TERMS: Address;Adolescent;Adoption;Adult;Age;Appalachian Region;attentional control;Behavior;Behavioral;Beverages;Black race;Body mass index;Calories;Child;Child Rearing;Chronic;comparison control;Consumption;County;critical period;Data;design;Development;diaries;Diet;digital divide;digital health;digital intervention;Disparity;drinking water;early childhood;Ecological momentary assessment;effectiveness research;efficacy evaluation;efficacy outcomes;efficacy research;efficacy trial;eHealth;Energy Intake;Enrollment;ethnic minority;Ethnic Origin;evidence base;Family;feeding;follow-up;Fructose;Glucose;Goals;Head Start Program;health literacy;Healthy Eating;Heterogeneity;high risk;Home;implementation research;improved;Insulin;Intake;Intervention;literacy;Literature;Maintenance;Malignant Neoplasms;Mediator;meetings;Methods;metropolitan;Mind;Monitor;Nursery Schools;Obesity;Outcome;Oxidative Stress;Parents;Pattern;Phase;Physical activity;post intervention;Preschool Child;Prevalence;Prevention Research;Prevention strategy;Primary Prevention;Process;process evaluation;programs;Quality of life;Race;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Reading;Recommendation;Reporting;Research;Research Project Grants;Resources;Rural;Rural Appalachia;rural area;Rural Community;rural counties;School-Age Population;secondary outcome;Service setting;social health determinants;socioeconomics;Source;Structure;sugar;sweetened beverage;System;Technology;theories;treatment effect;tumor;underserved community;user centered design;voucher;Water;water quality;Youth

PROJECT_TITLE: weSipSmarter: An efficacy trial to reduce sugary beverages among rural Head Start parent-child dyads

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Drug Abuse (NIDA only);Opioids;Prevention;Substance Misuse

ORG_CITY: DALLAS

ORG_NAME: BERKSHIRE BIOMEDICAL CORPORATION

ORG_STATE: TX

PHR: COPA is a computerized device specifically intended to deliver liquid-oral controlled and non-controlled medications. An Administrative Supplement is requested to conduct the additional research and test plan, including specifically the validation of interior fluidic path reprocessing and validation of continued antimicrobial effectiveness of submission drugs once filled, stored, and dispensed through the COPA device, prior to FDA De Novo submission.

PI_NAMEs: TIMBERLAKE, JOHN  (contact)

PROGRAM_OFFICER_NAME: KOSTOV, YORDAN VALTCHOV

PROJECT_TITLE: COPA, an Automated Medication Dispensing and Remote Management System for at Home Methadone Dispensing - Administrative Supplement

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(16)-B]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Mental Health;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: Project Narrative Studies from our group and others have demonstrated that disease causing mutations in neurotransmitter release machinery profoundly alters synaptic transmission. Here, we aim to uncover the impact of these mutations on synaptic signaling and plasticity by focusing on variants in the key fusion machinery component SNAP25 in multiple complementary systems. This effort has the overarching goal of obtaining new insight to the molecular synaptic substrates that underlie the pathophysiology as well as treatment of neuropsychiatric and neurological disorders.

PI_NAMEs: KAVALALI, EGE T (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: Action Potentials;Address;Affect;autism spectrum disorder;Biochemical;Biology;Brain Diseases;Clinical;Defect;Disease;disease-causing mutation;early childhood;electrical property;Electron Microscopy;Electrophysiology (science);Evoked Potentials;experimental study;Functional disorder;Funding;Goals;Hippocampus;Human;human embryonic stem cell;Impairment;insight;Investigational Therapies;Knock-in Mouse;Major Depressive Disorder;Mediating;Minor;Molecular;mouse model;Mutation;Nerve Degeneration;Nervous System Disorder;Neurodevelopmental Deficit;Neurologic;Neurons;neuropsychiatric disorder;neuropsychiatry;neurotransmission;neurotransmitter release;novel;optical imaging;Optics;Patients;postsynaptic;presynaptic;Process;Property;receptor;Receptor-Interacting Protein;Recycling;Regulation;Rodent;Role;Schizophrenia;Signal Pathway;Signal Transduction;SNAP receptor;structural biology;Structure;superresolution imaging;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;Synaptic Vesicles;System;Testing;Therapeutic;treatment response;Variant;Work

PROJECT_TITLE: Role of SNARE Interactions in Central Synapse Function

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Genetics;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: PROJECT NARRATIVE Prion disease is a fatal neurodegenerative disease caused by misfolding of the prion protein, or PrP. Drugs that lower the amount of PrP in the brain show a potential to both modify disease and dramatically extend healthy life in asymptomatic individuals at risk for prion disease, but to realize this potential we must identify, develop, and deeply understand a range of fluid biomarkers capable of reporting on risk and disease in real time in patients and at-risk individuals. This project will examine markers capable of reporting on 1) the earliest molecular stages of prion disease, 2) the basal state of asymptomatic individuals at risk for genetic prion disease, and 3) the consequences of lowering prion protein in the brain, with the twin goals of illuminating new prion biology and aiding informed clinical development of PrP-lowering drugs.

PI_NAMEs: MINIKEL, ERIC VALLABH (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Ablation;Address;Affect;age related;age related changes;Animals;Antisense Oligonucleotides;Biological Assay;Biological Markers;Biology;biomarker signature;Blood;Brain;Brain Pathology;brain tissue;Categories;Clinic;Clinical;clinical development;Clinical Trials;cohort;Dependence;Detection;Disease;Disease Marker;dosage;Down-Regulation;drug efficacy;Drug toxicity;Early treatment;effective therapy;Eligibility Determination;experimental study;Gene Dosage;Genetic Risk;Genotype;Goals;Hamsters;high risk;Human;human disease;Individual;insight;Intervention;Knock-out;Knockout Mice;Knowledge;Life;Liquid substance;lysosomal proteins;Mammals;Measures;medication safety;Molecular;molecular marker;mouse model;Mus;mutant;Mutation;mutation carrier;Nerve Degeneration;Nerve Tissue;Neurodegenerative Disorders;novel marker;Onset of illness;Pathogenesis;Pathogenicity;Pathologic;Patients;Peripheral;Peripheral Nervous System Diseases;Pharmaceutical Preparations;pharmacologic;Phase;Phenocopy;Phenotype;Plasma;pre-clinical;Prion Diseases;prion seeds;Prions;prognostic value;programs;Proteins;Proteomics;PrP;PrP gene;Rattus;Reporting;response;Rest;Risk;Safety;Sampling;sciatic nerve;Series;Signal Transduction;Symptoms;tau Proteins;Therapeutic;Time;Tissues;Twin Multiple Birth;Variant;wild-type PrP

PROJECT_TITLE: Biomarkers and mechanisms of PrP misfolding, mutation, and deficiency

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Primary Health Care;Social Determinants of Health;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Education among healthcare providers remains a major barrier to care for Transgender, Nonbinary, and Gender Diverse (TGD) individuals, who experience poor quality of healthcare and significant health disparities across many domains. By creating a comprehensive, longitudinal, systematically implemented, and reproducible curriculum for primary care residents on care for TGD populations, we can increase the workforce of high-quality, competent, affirming healthcare providers. Disseminating this curriculum will enhance the healthcare experiences of TGD people and expand access to gender affirming healthcare, thereby improving physical and mental health and reducing health disparities within this marginalized patient community.

PI_NAMEs: POLLOCK, LEALAH  (contact)

PROGRAM_OFFICER_NAME: BARR, ELIZABETH ANNE

PROJECT_TERMS: Address;Advisory Committees;Attitude;barrier to care;care providers;career;Caring;Chronic Care;Chronic Disease;Clinic;Clinical;clinical care;clinical training;Collaborations;Communities;community partnership;Competence;Complement;curriculum development;Dedications;design;Development;didactic education;Discrimination;Disease Management;Disparity;Education;Educational Curriculum;Educational process of instructing;effectiveness evaluation;Evaluation;experience;Exposure to;Family Practice;Fright;Future;Gender;gender affirmation;gender affirming care;gender affirming intervention;gender diverse;Gender Identity;Goals;Health;health care disparity;health care quality;health disparity;Health Personnel;Health Sciences;Health Services Accessibility;Healthcare;improved;Individual;Intervention;Knowledge;knowledge base;learning materials;Lesbian Gay Bisexual Transgender Queer;life span;maltreatment;Maps;marginalization;marginalized community;Medical;medical schools;Mental Health;multimodality;nonbinary;Outcome;Patient Care;patient oriented;patient population;Patients;Personal Satisfaction;Persons;physical conditioning;Population Heterogeneity;Preventive care;Primary Care;primary care practice;primary care provider;programs;Provider;Psyche structure;Publishing;Quality of Care;queer;Readiness;Reduce health disparities;Reproducibility;Research;Residencies;Rotation;routine care;Self Assessment;Site;skills;social;Strategic Planning;Supportive care;Surveys;Training;Training Programs;transgender;Trauma;United States;United States National Institutes of Health;Woman;Women's Health

PROJECT_TITLE: Queering the Curriculum: Preparing Family Medicine and Other Primary Care Residents to Care for Transgender, Non-Binary, and Gender Diverse People

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-P (57)]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Data Science;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Post-Traumatic Stress Disorder (PTSD);Precision Medicine

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE Despite significant advances in research and clinical care for mental illness, prediction of clinical course at the individual level remains elusive, in part due to a dearth of longitudinal data collected using assessments sensitive to individual change over time. Using a combination of ‘traditional’ clinical information (e.g., health records, standardized assessments) and more novel computational data (e.g., behavioral tasks with demonstrated sensitivity to latent constructs and to within-person change), this IMPACT-MH project will collect longitudinal data from a cohort of 2400 individuals, highly enriched for psychopathology across multiple diagnostic categories. These data will be used to conduct person-centered analyses focused on (i) individual-level prediction of outcomes; (ii) characterization of diverse clinical trajectories; and (iii) data-driven analyses to identify subgroups (aka, ‘biotypes’) that predict differences in outcomes at 2 years.

PI_NAMEs: PEARLSON, GODFREY D;PITTENGER, CHRISTOPHER JOHN (contact);YIP, SARAH

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Address;Affective;Behavior;behavior measurement;Behavioral;Behavioral Mechanisms;behavioral outcome;biotypes;burden of illness;case control;Categories;Cellular Phone;Child;Clinical;Clinical assessments;clinical care;clinical predictors;Clinical Research;Cognition;Cognitive;cohort;Collaborations;Communities;comparison group;Complex;computerized data processing;Control Groups;COVID-19;COVID-19 impact;Data;Data Coordinating Center;Data Scientist;Data Set;design;Development;Diagnosis;Diagnostic;Dimensions;disability;Disease;Dissociation;Ecosystem;Electronic Health Record;Etiology;Evolution;Family;Fingerprint;follow-up;Genetic;Goals;Growth;health record;Household;improved;Individual;individual patient;individualized medicine;Interview;large datasets;longitudinal analysis;longitudinal course;Machine Learning;Measures;Memory;Mental Depression;Mental disorders;Methods;Modeling;Moods;Natural Language Processing;neural network;neuroimaging;novel;Outcome;outcome prediction;Patient Self-Report;patient subsets;Patients;Pattern;person centered;Persons;Phenotype;Population;Post-Traumatic Stress Disorders;pre-trained transformer;predict clinical outcome;Predictive Analytics;predictive marker;predictive modeling;Predictive Value;Predictive Value of Tests;prognostic value;programs;Psychiatric Diagnosis;psychiatric symptom;Psychiatry;Psychopathology;Recommendation;recruit;Research;response;Rewards;Sampling;Schizophrenia;social health determinants;Standardization;statistical and machine learning;Subgroup;Symptoms;Tablets;Testing;Text;Time;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: IMPACT-MH: Clinical and behavioral fingerprints of psychopathology

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-S (01)]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cerebral Palsy;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rehabilitation

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative  Most children with cerebral palsy (CP) have communication challenges because of a speech disorder called dysarthria. This research will extend our study of how communication develops over time from early childhood into adulthood in people with CP. The information we obtain will allow us to predict young adult communication outcomes in very young children. This will allow us to determine what kind of speech therapy might help maximize quality of life beginning at the earliest possible age. We will also study the effects of a speech intervention, called speech supplementation, to see how much meaningful improvement in speech intelligibility occurs and who the best candidates are for the intervention.

PI_NAMEs: HUSTAD, KATHERINE C (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: 15 year old;20 year old;3 year old;Address;Adolescent;Adult;Age;alternative communication;Augmentative and Alternative Communication;base;Beginning of Life;behavioral clinical trial;Biometry;Cerebral Palsy;Characteristics;Child;Classification;Clinical;clinical decision-making;Clinical Trials;cohort;Communication;Communication difficulty;Cues;Data;data-driven model;Decision Making;Development;Dysarthria;early childhood;Early identification;Educational process of instructing;Elements;Evidence based intervention;experience;Foundations;Future;Goals;Growth;Guidelines;Heterogeneity;improved;Intervention;Intervention Studies;Intervention Trial;Investigation;Knowledge;Language;language comprehension;Language Development;language outcome;Life;Maps;Measures;Methods;Modeling;motor disorder;motor impairment;Outcome;outcome prediction;Performance;Persons;Phase;Phase I Clinical Trials;predictive modeling;prospective;Publishing;Quality of life;recruit;remediation;Research;Speech;Speech Development;Speech Disorders;Speech Intelligibility;Speech Therapy;Supplementation;Testing;Time;Validation;Visit;Visual;Work;young adult;Youth

PROJECT_TITLE: Communication Development in Children with Cerebral Palsy

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Behavioral and Social Science;Cannabidiol Research;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Conditions Affecting the Embryonic and Fetal Periods;Dietary Supplements;Drug Abuse (NIDA only);Maternal Health;Mental Health;Natural Products;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Substance Misuse;Women's Health Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Cannabis use during pregnancy is increasing with its legalization in many states. The outcome of this proposal could have an innovative public health effect to protect the brain development of fetuses whose mothers continue to use cannabis despite medical advice to abstain. The effects would include decreased risk of mental problems in the children, including their own substance use in adolescence.

PI_NAMEs: HOFFMAN, MARIA CAMILLE;HUNTER, SHARON K (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: Abate;Address;Adolescence;Adverse effects;Amniotic Fluid;Anxiety;Attention;Auditory;Auditory Evoked Potentials;Behavior;Behavioral;Belief;Birth;Brain;Cannabidiol;Cannabinoids;Cannabis;cannabis cessation;Cerebrum;Child;Child Behavior;Child Development;Childhood;Choline;choline supplementation;cholinergic;Cigarette;Clinical;Clinical Trials;CNR1 gene;Cognition;Cognitive;Conceptions;Controlled Clinical Trials;Corn Oil;Counseling;critical period;Data;Development;Diet;dietary;double-blind placebo controlled trial;effective therapy;Effectiveness;egg;Electroencephalography;Electrophysiology (science);Ethics;Exposure to;fetal;Fetal Development;fetal marijuana exposure;Fetus;Food;Hair;Hippocampus;Human Milk;improved;Infant;Informal Social Control;inhibitory neuron;innovation;Intake;Interneurons;Investigation;Knowledge;Laboratories;Late Effects;Lecithin;Legal;Life;Marijuana;marijuana use;marijuana use in pregnancy;maternal marijuana use;Measures;Meat;Medical;Mental Depression;Mental disorders;Morning Sickness;Mothers;Natural Remedy;Nausea;neonate;nerve supply;neurotransmission;Newborn Infant;Nicotinic Receptors;novel;offspring;Outcome;paired stimuli;Parents;Patient Self-Report;Perinatal Care;pill;placebo group;Placebos;Planned Pregnancy;Plasma;postnatal;postnatal period;Pregnancy;Pregnant Women;prenatal;prenatal exposure;prenatal intervention;prevent;prospective;protective effect;Provider;Psyche structure;Public Health;Questionnaires;Randomized;Randomized, Controlled Trials;Regulation;Reporting;response;Risk;Safety;Scalp structure;sensory gating;Serum;Signal Transduction;Social Behavior;Source;Soybeans;Standardization;Stimulus;Stress;substance use;Supplementation;Synaptic Transmission;Temperament;Testing;Tetrahydrocannabinol;THC exposure;Third Pregnancy Trimester;Toddler;translational model;treatment group;Urine;Woman;Women's study;Work

PROJECT_TITLE: Clinical Trial of Maternal Choline Supplements to Mitigate Effects of Prenatal Cannabis Exposure on Early Brain Development.

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]