NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Orphan Drug;Precision Medicine;Rare Diseases;Tuberculosis

PHR: PROJECT NARRATIVE The Candidate Clinical Condition as Prognostic Outcome for TB Study (C3PO) will find out whether using new tests at the end of tuberculosis treatment can identify which people will relapse with tuberculosis after treatment. The first new test, called the RS ratio®, can detect residual tuberculosis bacteria in sputum that standard culture techniques do not pick up. The second new test detects unresolved inflammation in blood that shows that the immune system of someone treated for tuberculosis is still battling the disease.

PI_NAMEs: CATTAMANCHI, ADITHYA ;DENKINGER, CLAUDIA MARIA;NAHID, PAYAM  (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Acceleration;Adolescent;Adult;Aftercare;Antibiotics;Bacteria;Biological;Biological Assay;Biological Markers;Biological Monitoring;biomarker identification;Blood;Blood Tests;Cause of Death;clinical candidate;clinical risk;Clinical Trials;cohort;Combined Antibiotics;Culture Techniques;design;Detection;Development;Diagnostic;diagnostic development;Disease;Ethambutol;follow-up;Funding;Gene Expression Profile;Genetic Transcription;Goals;Human;Immune response;Immune system;improved;individual patient;Infection;Inflammation;Inflammatory;isoniazid;Measurable;Methods;microbial;Molecular;Monitor;Mus;Mycobacterium tuberculosis;novel;Outcome;pathogen;Patients;Persons;Pharmaceutical Preparations;pharmacodynamic biomarker;Pharmacodynamics;Phase;phase 3 testing;phase II trial;phase III trial;point of care;predict clinical outcome;Predictive Value;Predisposition;prognostic;prototype;Pulmonary Tuberculosis;Pyrazinamide;Recurrence;Regimen;Relapse;relapse risk;Research;Residual Neoplasm;Residual state;response;response biomarker;Ribosomal RNA;Rifampin;Risk;RNA chemical synthesis;rRNA Precursor;Signal Transduction;Site;Sputum;Testing;Time;tool;transcriptome;Translating;Treatment Effectiveness;Treatment outcome;trial design;Tuberculosis;tuberculosis diagnostics;tuberculosis drugs;tuberculosis treatment;Uganda;Vietnam;Vietnamese

PROJECT_TITLE: C3PO - The Candidate Clinical Correlate of Prognostic Outcome for TB Study


ADMINISTERING_IC: HG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Disability Research;Genetic Testing;Genetics;Health Services;Human Genome;Pediatric;Prevention

ORG_CITY: SALT LAKE CITY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The University of Utah Center for Excellence in ELSI research explores issues relevant to population testing and screening for genetic conditions in the healthcare of women and children, as well as ELSI issues arising from testing and screening in the broader family context and responses to disabilities identified through genetic technologies. The Center supports cores in research, education and career advancement, and administration.

PI_NAMEs: ROTHWELL, ERIN  (contact);TABERY, JAMES

PROGRAM_OFFICER_NAME: LOCKHART, NICOLE C

PROJECT_TERMS: Address;Administrative Efficiency;Advisory Committees;Affect;Award;Cancer Center Planning Grant;career;career development;Career Mobility;carrier testing;Characteristics;Child;Collaborations;college;Communication;Communication Tools;Communities;Companions;cost effectiveness;Decision Making;Development;disability;Disabled Children;Discipline;Discipline of Nursing;Discipline of obstetrics;Education;Educational Activities;Educational Assessment;ethical, legal, and social implication;experience;Faculty;Family;Family Relationship;family support;father role;Forensic Medicine;Funding;Genetic;Genetic Counseling;Genetic Diseases;Genetic Screening;genetic technology;genetic testing;graduate student;Grant;health communication;health disparity;health literacy;Healthcare;implementation science;improved;Individual;Informed Consent;Institution;Laws;Leadership;Legal;legal implication;Link;meetings;member;Mentors;Mentorship;National Human Genome Research Institute;Neonatal Screening;Newborn Infant;patient screening;Pediatrics;Philosophy;Policies;policy implication;Population;population based;Population Scientist Supplement (R25);Postdoctoral Fellow;prenatal;prenatal testing;Process;Productivity;programs;Public Health;Research;Research Activity;Research Personnel;Research Project Grants;Resources;response;Schedule;screening;Screening procedure;screening services;social;social implication;Structure;Students;Testing;Treatment Effectiveness;undergraduate student;United States National Institutes of Health;Universities;Utah;Woman;Work

PROJECT_TITLE: University of Utah Center of Excellence in ELSI research (UCEER)


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurodegenerative;Neurosciences;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Transplantation

ORG_CITY: AUSTIN

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: PROJECT NARRATIVE  Segmental-loss peripheral nerve injuries are currently rather in-effectively treated with cadaveric nerve allografts, stimulating slow regeneration of outgrowing axons with various drugs or other substances. Our proposal seeks to investigate and develop potentially synergistic methods of axon fusion and localized immunosuppression of peripheral nerve allografts to circumvent these problems and lead to a new standard of treatment for segmental-loss peripheral nerve defects.

PI_NAMEs: BITTNER, GEORGE DAVIS (contact);BUSHMAN, JARED SHANE

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Ablation;Acceleration;Allografting;Autologous Transplantation;Axon;axon regeneration;Behavior;Behavioral;Cadaver;Clinical;clinical practice;cost;Cytoplasm;Defect;Devices;Esthesia;Functional disorder;functional improvement;Graft Rejection;Immune response;Immunosuppression;improved;Injury;Methods;Natural regeneration;Nerve;nerve gap;Nervous System;novel;Outcome;Patient-Focused Outcomes;Peripheral nerve injury;Peripheral Nerves;Pharmaceutical Preparations;Polyethylenes;prevent;Recovery;reinnervation;repaired;Risk;standard care;Surgical sutures;Technology;Therapeutic immunosuppression;Tissues;Translating;Translations;Wallerian Degeneration

PROJECT_TITLE: Translating Novel Peripheral Nerve Allograft Technologies Toward Clinical Use


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: LA JOLLA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PI_NAMEs: SUBRAMANIAM, SHANKAR  (contact)

PROGRAM_OFFICER_NAME: PAPANICOLAOU, GEORGE

PROJECT_TERMS: Address;Biological;biological systems;biomarker identification;Clinical;Computing Methodologies;Data;Data Commons;data integration;Data Sources;Development;diverse data;Funding;Future;Genotype;Information Systems;Infrastructure;Knowledge;Modeling;multiple data types;phenotypic data;Process;Research;Research Personnel;System;tool;Vision

PROJECT_TITLE: Biomedical Data Commons Workbench (BDCW)


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: OTHER BASIC SCIENCES

PHR: PROJECT RELEVANCE RNA oxidation precedes motor neuron degeneration in ALS, yet its consequences in the context of disease are not understood. This project seeks to identify the effects of RNA oxidation on several aspects of RNA processing and the cellular mechanisms by which it might lead to neuronal death. This work will help clarify the molecular mechanisms underlying RNA oxidation and identify potential therapeutic intervention strategies.

PI_NAMEs: CHAIM, ISAAC ALEXANDER (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: ALS patients;Amyotrophic Lateral Sclerosis;cell injury;Cells;diagnostic strategy;Disease;DNA;Genetic Transcription;high risk population;induced pluripotent stem cell;insight;Intervention;Methods;MicroRNAs;Modeling;Molecular;motor neuron degeneration;Motor Neurons;mouse model;neuron loss;Neurons;novel;Organoids;oxidation;Oxidative Stress;Patients;Proteins;Reactive Oxygen Species;Resolution;RNA;RNA Processing;RNA-Binding Proteins;RNA-Protein Interaction;Sampling;Spinal;Spinal Cord;Testing;Therapeutic Intervention;Tissues;Transcript;Translations;Work

PROJECT_TITLE: Oxidized microRNAs identification in ALS patient samples


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: COLLEGE PARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Project Narrative Physiological transport of fluid, molecules, proteins, and cells throughout the body is critical for homeostasis. While transport processes like cell migration and molecular passage across cellular barriers are well documented, less is known about transport across the interstitial tissue spaces and into lymphatic vessels, the natural conduit from peripheral tissues to draining lymph nodes, where the immune response is shaped. The proposed research program combines mucosal, lymphoid tissue, and lymphatic vessel physiology with engineering approaches, such as building relevant in vitro model systems and designing nanoparticle probes, to increase our understanding of protein, particulate, and other material transport across interstitial tissues and into lymphatic vessels.

PI_NAMEs: MAISEL, KATHARINA  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: adaptive immune response;Address;Affect;Attention;Biological;Biological Models;Blood Vessels;cell motility;Cells;Communities;Computer Models;delivery vehicle;design;Diffusion;Disease;draining lymph node;Drug Delivery Systems;Drug Targeting;Edema;Engineering;extracellular;Extracellular Space;fluid flow;Homeostasis;Immune response;immunoregulation;in vitro Model;Inflammation;insight;interstitial;Knowledge;Light;Liquid substance;lymph nodes;Lymphatic;lymphatic circulation;lymphatic vessel;Lymphoid Tissue;Maintenance;Methods;model design;Modeling;Molecular;Mucous Membrane;nanoparticle;particle;Particulate;Peripheral;Physiological;Physiological Processes;Physiology;Process;programs;Proteins;Regulation;Research;Rheology;Shapes;Slice;Structure;Techniques;Therapeutic;Time;Tissues;tool;Transport Process;Vision;Work

PROJECT_TITLE: Regulation and modeling of transport across tissue barriers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-R(55)R]


NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_CITY: NEW YORK

ORG_NAME: CITY COLLEGE OF NEW YORK

ORG_STATE: NY

PHR: Project Narrative This works aims to study the role of inflammatory proteins in the development and progression of chronic disease. We will use an injectable fluorescent nanosensor network to quantify inflammatory proteins at the site of disease as well as throughout the body. We expect to understand the role of inflammation in chronic disease and to potentially discover new inflammatory signatures for different stages of each disease.

PI_NAMEs: WILLIAMS, RYAN MARTIN (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Acute;Animals;Autoimmune Diseases;Blood;Carbon;Cardiovascular Diseases;Cells;Chronic;Chronic Disease;Chronic Kidney Failure;Chronic Phase;Communicable Diseases;Coupled;cytokine;Cytokine Signaling;Data;design;Detection;Development;Disease;disease model;Disease Progression;Encapsulated;end stage disease;Ensure;Evaluation Research;Exhibits;Future;Hydrogels;Imaging Techniques;Immune response;Immunoassay;implantation;In Situ;Inflammation;Inflammatory;Inflammatory Response;Injectable;Injections;insight;Kinetics;Laboratories;Light;Location;Malignant Neoplasms;Measurement;Measures;minimally invasive;Modeling;molecular imaging;Mus;Musculoskeletal Diseases;nanosensors;Neurodegenerative Disorders;Organ;Pathogenesis;Proteins;rapid detection;Research Methodology;Rodent Model;Role;Scientist;sensor;Signal Transduction;Site;Specificity;Stains;System;systemic inflammatory response;technology validation;Time;Time Study;transcriptome sequencing;whole animal imaging;Work

PROJECT_TITLE: Integrating Real-Time Multi-System Cytokine Signaling in Chronic Disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Parkinson's Disease;Precision Medicine;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Parkinson’s disease, multiple system atrophy, progressive supranuclear palsy, and corticobasal syndrome are devastating neurodegenerative diseases that cause a progressive debilitation and eventually death. Misdiagnosis and confusion of these diseases causes much suffering and hampers conduction of clinical trials. We will test a new biomarker panel for distinguishing among these diseases using a blood test, which will substantially facilitate development of new treatments.

PI_NAMEs: BITAN, GAL  (contact)

PROGRAM_OFFICER_NAME: SWANSON-FISCHER, CHRISTINE R

PROJECT_TERMS: Administrative Supplement;Anxiety;Autonomic Dysfunction;Bachelor's Degree;biobank;Biochemistry;Biological Markers;biomarker discovery;biomarker identification;biomarker panel;Blood Tests;candidate marker;career;career development;Cell Separation;Cellular biology;Cessation of life;Chemistry;Clinical Trials;Collaborations;Confusion;corticobasal syndrome;Culture Media;Data;Dementia;Development;Diagnosis;Diagnostic;Diagnostic tests;disadvantaged background;Disease;drug development;drug discovery;Eligibility Determination;experience;experimental study;extracellular vesicles;Family;Genes;Goals;graduate student;Grant;Health;high school;Human;Immunoprecipitation;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Knowledge;Mass Spectrum Analysis;Measures;Mental Depression;Mentors;Methods;minimally invasive;Monitor;Movement Disorders;Multiple System Atrophy;nerve stem cell;Neurodegenerative Disorders;Neuronal Differentiation;Neurons;novel marker;Ontology;parent grant;parent project;Parents;Parkinson Disease;Parkinsonian Disorders;patient derived induced pluripotent stem cells;Patients;Productivity;Prognosis;Progressive Supranuclear Palsy;protein biomarkers;Proteomics;Research;Research Personnel;Sampling;Serum;Signal Transduction;stem cells;Students;Symptoms;synucleinopathy;Talents;Tauopathies;Techniques;Testing;Therapeutic Intervention;Time;Training;Translational Research;Work

PROJECT_TITLE: Biomarker discovery for parkinsonian diseases in extracellular vesicles from iPSC-derived neurons


ORG_CITY: SOUTH SAN FRANCISCO

ORG_NAME: VERILY LIFE SCIENCES LLC

PI_NAMEs: BOOKMAN, MATT  (contact)

PROGRAM_OFFICER_NAME: RESAT, HALUK

PROJECT_TERMS: Acceleration;Adoption;Back;Clinical;cloud based;Code;cohort;Collaborations;Common Data Element;Communities;computerized tools;Consumption;Custom;Data;data access;Data Analyses;Data Collection;data ecosystem;data harmonization;data modalities;data repository;Data Sources;data wrangling;Dependence;design;differential expression;Ecosystem;Ensure;Environment;experience;FAIR principles;Feedback;Future;Genes;Genetic;Genomics;graphical user interface;Head;Health;improved;insight;Label;Leadership;Legal;Modality;multiple data sources;Non-Insulin-Dependent Diabetes Mellitus;Ontology;Parkinson Disease;Process;professional atmosphere;programs;prototype;Research;Research Personnel;Risk;Running;Science;Security;Services;Source;Sports;statistics;success;System;Systemic Lupus Erythematosus;Systems Biology;Textiles;tool;transcriptomics;United States National Institutes of Health;virtual;Vision;Work

PROJECT_TITLE: SysBio FAIRplex: a FAIR PLatform for EXploration of Systems Biology

STUDY_SECTION: CFOT

STUDY_SECTION_NAME: Common Fund Other Transactions Programs[CFOT (04)]


ED_INST_TYPE: PRIMATE CENTERS

FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: HIV/AIDS

ORG_CITY: SEATTLE

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE We propose to purchase pens with adjoining enclosures for macaques assigned to HIV/AIDS research projects in our Seattle facility. Housing in pens will increase animal welfare, thus improving the research model. Animals will be trained to enter the adjoining cages voluntarily, allowing access for research or clinical procedures.

PI_NAMEs: OSTENDORF, MARI  (contact)

PROGRAM_OFFICER_NAME: BUHRING, BETTINA D

PROJECT_TERMS: Animal Experimentation;Animal Housing;Animal Welfare;Animals;Behavior;Blood;Clinical;Collection;Complex;design;Environment;environmental enrichment for laboratory animals;Event;experience;Floor;Height;HIV;HIV/AIDS;Housing;improved;Individual;Link;Macaca;Modeling;nonhuman primate;Primates;Procedures;Research;Research Project Grants;sample collection;Sampling;Sedation procedure;Services;Side;Social Interaction;Socialization;stress reduction;Training;United States National Institutes of Health;Washington;Well in self;Work

PROJECT_TITLE: Washington National Primate Research Center


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Chronic Pain;Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Summary and Narrative Many mental health and neurological diseases have significant affective components of their disease and/or significant comorbidities with affective disorders, such that treating the affective component of the disease is beneficial for treating the whole disease process. In the parent award of this proposal, ultrasonic uncaging of ketamine will be applied to the anterior cingulate cortex of patients with chronic pain to treat the affective component of this disorder – to modulate how severe the patient experiences pain, less so modulating whether they experience pain in the first place. This same strategy could in principle be applied to other neuropsychiatric disorders that have a strong affective component. In particular opioid use disorder (OUD) is a significant cause of morbidity and mortality worldwide with a strong affective component. Traditional treatments like buprenorphine or methadone often fail to address the mood disturbances associated with OUD, leading to high relapse rates. Specifically, the withdrawal/abstinence period of OUD is associated with a negative affective state, dubbed ‘hyperkatifeia,’ that predisposes to relapse later. Like in the chronic pain application, ketamine uncaging targeted to a critical brain region could treat the affective component of substance use disorders, including OUD, to break the cycle of binge, withdrawal, and relapse that defines the disorder. In this training period, the candidate will explore the use of ultrasonic ketamine uncaging to modulate affective behaviors in rodent models of chronic pain as well as of OUD. This activity will better define the protocols for ultrasonic ketamine uncaging to be used in the clinical trial phase of the parent award, guide interpretation of the clinical and physiologic data in that clinical trial phase, and generate data to suggest further applications of ketamine uncaging, and the use of ultrasonic uncaging more broadly to treat affective disorders and the affective component of neuropsychiatric disease. During the preclinical phase of the parent award, the candidate will gain training in in vivo application of therapeutic ultrasound, neurobehavioral assay development and implementation, quantitative video behavioral analysis, functional ultrasound imaging, and neuroscientific data analysis. For the clinical phase of the parent award it is anticipated that the candidate will stay with the investigatory group, with or without a successful extension of this funding, to gain training in the clinical use of therapeutic ultrasound and neuropsychological trial implementation.

PI_NAMEs: AIRAN, RAAG D (contact);WILLIAMS, NOLAN R.

PROGRAM_OFFICER_NAME: HUDAK, ERIC MICHAEL

PROJECT_TERMS: Abstinence;Address;Affective;affective disturbance;analog;Anterior;anxiety-like behavior;assay development;awake;Behavior;behavior measurement;Behavioral;Biological Assay;Brain region;Buprenorphine;chronic pain;chronic pain management;chronic pain patient;cingulate cortex;Clinical;clinical translation;Clinical Trials;comorbidity;Control Groups;Data;Data Analyses;Disease;Dose;effective therapy;Ethology;experience;field study;Functional Magnetic Resonance Imaging;Funding;Goals;Image;Imaging Device;in vivo;Infusion procedures;Ketamine;Machine Learning;Measures;Mediating;Mental Health;Methadone;Modeling;Mood Disorders;Morbidity - disease rate;morphine administration;Morphine Sulfate;mortality;negative affect;nerve injury;Nervous System Disorder;neural;neurobehavioral;Neurons;neuropsychiatric disorder;Neuropsychology;non-opioid analgesic;opioid use disorder;opioid withdrawal;Outcome;Pain;pain model;parent project;Patients;Phase;Physiological;placebo group;pre-clinical;Process;Protocols documentation;Rattus;Relapse;Resolution;response;Rodent;Rodent Model;spared nerve;spatiotemporal;Substance Use Disorder;Therapeutic;Therapeutic Uses;Training;Ultrasonics;Ultrasonography;ultrasound;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Clinical Translation of Ultrasonic Ketamine Uncaging for Non-Opioid Therapy of Chronic Pain


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Disorders;Neurosciences

ORG_DEPT: ANESTHESIOLOGY

PHR: Project Narrative Millions of people experience general anesthesia each year in the United States, yet the mechanisms governing anesthetic actions are unclear. The period of arousal from anesthesia, termed emergence, is a particularly sensitive and dangerous time in clinical anesthesia care, and no therapeutic strategy currently exists for modifying emergence. This equipment supplement will support studies aimed at elucidating the inhibitory cellular, circuit, and behavioral mechanisms of emergence from general anesthesia in order to inform the development of mechanistically targeted interventions.

PI_NAMEs: HESHMATI, MITRA  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Agitation;Anesthesia procedures;Anesthetics;Area;Arousal;awake;Behavior;Behavioral;Behavioral Mechanisms;Brain;Caring;Cell Adhesion Molecules;cell type;Cells;Clinical;Dangerousness;Delirium;Development;Disease;Electrophysiology (science);Equilibrium;Equipment;experience;Foundations;General Anesthesia;Genes;Inhibitory Synapse;Intervention;Investigation;knock-down;life span;Light;Machine Learning;Maps;Mediating;Microscopy;mouse model;Mus;neuroligin 2;Neurons;optical sensor;Outcome;Patients;Persons;postsynaptic;pre-clinical;Pre-Clinical Model;programs;Research;Resolution;Rodent Model;scaffold;Signal Transduction;single cell sequencing;Stress;Synapses;synaptic function;Synaptic plasticity;Therapeutic;therapy design;Time;transcriptome sequencing;United States;Work

PROJECT_TITLE: Mechanisms of emergence from general anesthesia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Prevention;Women's Health Research

ORG_CITY: KIGALI

ORG_COUNTRY: RWANDA

ORG_FIPS: RW

ORG_NAME: RESEARCH FOR DEVELOPMENT

PHR: NARRATIVE Sub-Saharan Africa carries the highest burden globally of both HIV and cervical cancer (CC). Cervical Cancer is 6-fold more common in women with HIV, and is preventable via vaccination prior to HPV exposure, or through screening and treating women for HPV infection or cervical lesions. Rwanda is a low-income country with high burden of both HIV and cervical cancer and limited research capacity for investigators to conduct high impact research in this area. Building research capacity for investigators to study this population at a dual burden of disease could contribute towards strategies to mitigate that burden

PI_NAMEs: ANASTOS, KATHRYN M.;MURENZI, GAD  (contact)

PROGRAM_OFFICER_NAME: FRECH, MARIA SILVINA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Affect;Africa South of the Sahara;African;Age;AIDS prevention;Anemia;anti-cancer research;Anti-Retroviral Agents;Area;burden of illness;cancer care;Cancer Center;cancer diagnosis;Cancer Etiology;cancer invasiveness;Cancer Patient;cancer prevention;Cancer Prevention Trial;cancer therapy;care seeking;Caring;Cervical;Cervical dysplasia;Cessation of life;Clinic;Clinical;Clinical Trials;Continuity of Patient Care;Country;Development;Diagnosis;Diagnostic;Disease;Early Diagnosis;Emergency Situation;Enrollment;experience;Foundations;General Population;Goals;high risk population;HIV;HIV diagnosis;HIV Seronegativity;Human papilloma virus infection;Human Papillomavirus;improved;Incidence;interest;Interruption;Interview;Investments;Lead;Lesion;low and middle-income countries;low income country;Malawi;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mentors;Mentorship;Morbidity - disease rate;mortality;Oncologist;Policies;Population;Positioning Attribute;pragmatic trial;premalignant;Prevalence;Prevention;Public Health;Qualitative Research;Research;Research Personnel;Research Project Grants;Resources;response;Rwanda;screening;Screening for cancer;screening guidelines;screening program;Services;Site;skills;Staging;Standardization;Toxicity due to chemotherapy;Training;Transfusion;Treatment outcome;Vaccination;Woman;women's diagnosis;Women's mortality;women's prevention;women's treatment;Women's trial

PROJECT_TITLE: Characterizing women living with HIV at cervical cancer diagnosis in Rwanda: Mentored Research under the Rwanda CASCADE Clinical Trials Site


ADMINISTERING_IC: ES

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Prevention

ORG_CITY: COLUMBUS

ORG_NAME: BATTELLE CENTERS/PUB HLTH RES & EVALUATN

ORG_STATE: OH

PI_NAMEs: BURBACK, BRIAN  (contact)

PROJECT_TERMS: Adverse effects;Amines;Biological;bisphenol A;cardiovascular health;Cardiovascular system;Chemicals;Chemistry;Contracts;Development;disorder prevention;Dose;dose information;Environmental Exposure;Evaluation;Exposure to;Formulation;Goals;Hazard Identification;Hazardous Chemicals;Health;Heightened Cancer Risk;Human;Individual;Inhalation;Materials Testing;method development;National Toxicology Program;Outcome;Preparation;Process;programs;public health research;Reporting;Research;Risk Assessment;Risk Factors;Rodent;Sampling;Services;sound;Specific qualifier value;Testing;Toluene;Toxic effect;Toxicity Tests;Toxicology;Validation;Xylene

PROJECT_TITLE: Chemistry Services for the Division of Translational Toxicology (General and Administrative)


NIH_SPENDING_CATS: Complementary and Integrative Health;Dietary Supplements;Natural Products;Nutrition;Patient Safety;Prevention

PROJECT_TERMS: Academia;Adverse effects;Anthracenes;Aromatic Compounds;Benzo(a)pyrene;Biological Assay;Black Cohosh Extract;Botanical dietary supplements;Botanicals;Chemicals;Chemistry;Chrysenes;Contracts;Development;disorder prevention;Dose;dose information;Environmental Exposure;Environmental Science;Evaluation;Exposure to;fluoranthene;Fluorenes;Fractionation;Goals;Government;Hazard Identification;Hazardous Chemicals;Health;Health Sciences;Heightened Cancer Risk;Human;in vitro testing;Individual;Industry;Manufacturer;National Toxicology Program;Nonprofit Organizations;Outcome;Process;programs;public health research;Pyrenes;Reporting;Research;Research Personnel;Risk Assessment;Risk Factors;Safety;safety assessment;Services;sound;Specific qualifier value;Testing;tool;Toxic effect;Toxicity Tests;Toxicology

PROJECT_TITLE: Chemistry Services for the Division of Translational Toxicology (Mixtures)


NIH_SPENDING_CATS: Endocrine Disruptors;Prevention

PROJECT_TERMS: Adverse effects;cardiovascular health;Cardiovascular system;Chemicals;Chemistry;Contracts;Development;disorder prevention;Dose;dose information;Environmental Exposure;Evaluation;Exposure to;Formulation;Goals;Hazard Identification;Hazardous Chemicals;Health;Heightened Cancer Risk;Human;Individual;method development;National Toxicology Program;Outcome;Poly-fluoroalkyl substances;Preparation;Process;programs;public health research;Reporting;Research;Risk Assessment;Risk Factors;Services;sound;Specific qualifier value;task analysis;Testing;Toxic effect;Toxicity Tests;Toxicology

PROJECT_TITLE: Chemistry Services for the Division of Translational Toxicology (Per- and polyfluoroalkyl substances)


NIH_SPENDING_CATS: Cancer;Prevention

ORG_CITY: ROCKVILLE

ORG_NAME: WESTAT, INC.

PI_NAMEs: WOODY, TORRISE  (contact)

PROJECT_TERMS: Advocate;Cancer Control;Cancer Patient;cancer risk;Communities;Congresses;Consumer Liaison;Contracts;Data Collection;data management;data visualization;design;Division of Cancer Control and Population Sciences;evidence base;Extramural Activities;General Population;Government;Health;Incidence;Malignant Neoplasms;Meta-Analysis;National Cancer Institute;Outcome;Reporting;Research;Research Methodology;Resources;Review Literature;Services;Statistical Data Interpretation;Surveys;tool;tool development;Training;United States Dept. of Health and Human Services;United States National Institutes of Health

PROJECT_TITLE: SCIENTIFIC SUPPORT SERVICES FOR THE NATIONAL CANCER INSTITUTE, DIVISION OF CANCER CONTROL AND POPULATION SCIENCES (DCCPS), CALL ORDER 3 UNDER BPA #HHSN261201800002B


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: MENLO PARK

ORG_NAME: AN2 THERAPEUTICS, INC.

PI_NAMEs: ALLEY, M.R.K. (DICKON)  (contact)

PROJECT_TERMS: Advanced Development;biodefense;Burkholderia pseudomallei;candidate selection;Chemistry;Clinical assessments;Development;efficacy evaluation;Emerging Communicable Diseases;lead optimization;manufacture;Melioidosis;novel therapeutics;pathogen;pre-clinical;product development;research and development;Research Support;safety assessment;Therapeutic;therapeutic candidate;therapeutic development

PROJECT_TITLE: Development of a Novel Therapeutic for Melioidosis


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: RICHMOND

ORG_NAME: VA VETERANS ADMINISTRATION HOSPITAL

ORG_STATE: VA

PHR: Chronic liver disease, leading to cirrhosis is epidemic in Veterans. A major complication of cirrhosis is hepatic encephalopathy (HE), that can cause lasting brain damage if it recurs. Current treatments for HE target inflammation produced in the bowels but are often not effective. Our preliminary study showed that feces from a healthy donor, also known as fecal microbial transplant (FMT), was safe using an enema and oral capsule routes. However, it is not clear which route or combination of fecal transplant administration would be helpful in preventing hospitalizations in HE patients. It is also unclear whether it is the microbes in the FMT or their products that are associated with the improvement. Our proposed trial studies the effect of oral and enema routes of FMT in Veterans with HE to prevent hospitalizations, and also aims to find out which FMT components are associated with improvement using animal models.

PI_NAMEs: BAJAJ, JASMOHAN S (contact)

PROJECT_TERMS: Animal Model;Antibiotics;Ascites;Bile Acids;Brain;Brain Injuries;capsule;Caregiver Burden;Caregivers;chronic liver disease;Cirrhosis;Clinical;Clinical Trials;Clostridium difficile;Collection;Colon;Complication;Data;Dependence;Development;Disease;Donor person;Double-Blind Method;end stage liver disease;enema administration;Epidemic;Evaluation;experience;experimental study;fecal transplantation;Feces;Foundations;Future;Germ-Free;Growth;gut dysbiosis;gut inflammation;gut microbiota;Hepatic Encephalopathy;hospital readmission;Hospitalization;host microbiota;Human;Impairment;improved;Inflammation;inflammatory milieu;Intervention;intestinal barrier;Intestinal permeability;Intestines;Investigation;Lactulose;laxative;Link;Liver Cirrhosis;Liver diseases;Machine Learning;Mediating;Mediator;Microbe;microbial;microbial composition;microbial products;microbiota composition;military veteran;Morbidity - disease rate;mortality;Mus;neuroinflammation;Oral;Oral Administration;Outcome;Outpatients;Patients;Phase II Clinical Trials;Placebos;Population;prevent;primary outcome;Process;Protocols documentation;Publishing;Quality of life;Randomized;randomized trial;Rectal Administration;Rectum;Recurrence;Research;Resources;Rest;rifaximin;Role;Route;Safety;sample collection;Sampling;Serum;Severities;Signal Transduction;Small Intestines;standard of care;Sterility;success;Sulfate;System;systemic inflammatory response;Testing;Underserved Population;Veterans

PROJECT_TITLE: Fecal Microbiota Transplant in Veterans with Cirrhosis


ORG_CITY: EAST ORANGE

ORG_NAME: VA NEW JERSEY HEALTH CARE SYSTEM

ORG_STATE: NJ

PHR: Project Narrative/Health Relevance About 5,000 Veterans take their own lives each year. While the VA has currently mandated a multifaceted prevention approach, including suicide risk screening of all Veterans seen for mental health issues, the continued large numbers of Veterans who attempt or die of suicide points to the desperate need for improved prediction of suicide risk. Existing prediction methods are subject to high rates of false alarm, so that only about 10% of Veterans flagged as at-risk actually attempt suicide; this high false alarm rate potentially diffuses critical clinical resources away from those who need them most. The development of more accurate predictive tools has been identified as one of the most important areas in suicide research, and would also improve the evidence base for clinical therapy, by more accurately identifying at-risk clients to participate in research trials and evaluating treatment effectiveness across time.

PI_NAMEs: MYERS, CATHERINE E (contact)

PROJECT_TERMS: Acute;Area;attentional control;Behavior;Behavioral;Cessation of life;Chronic;Client;Clinical;Clinical assessments;clinically relevant;Cognitive;cognitive process;cohort;Computer Models;computerized;computerized tools;Computers;Data;Death Rate;Development;Diffusion;Event;evidence base;executive function;experience;Feedback;Feeling hopeless;Health;high risk;improved;Impulsivity;Individual;innovation;Inpatients;insight;instrument;Interruption;Intervention;Learning;Measures;medical specialties;Mental Depression;Mental Health;Meta-Analysis;Methods;military veteran;Neurocognitive;neurocognitive test;novel;novel strategies;Opiate Addiction;Outcome Assessment;Patient Self-Report;Patients;Performance;Post-Traumatic Stress Disorders;predictive marker;predictive modeling;predictive tools;Prevention approach;Process;prospective;psychiatric inpatient;Psychiatric therapeutic procedure;Punishment;recruit;Reporting;Research;Resources;response;reward processing;Rewards;Risk;Risk Assessment;Risk Factors;Sampling;screening;Semantics;skills;Specificity;substance use;suicidal;suicidal behavior;suicidal individual;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;Syndrome;Task Performances;Techniques;telehealth;Testing;Therapeutic;therapeutic target;Time;trait;Treatment Effectiveness;Veterans;Work

PROJECT_TITLE: Neurocognitive markers of short-term risk for suicidal behavior in high-risk Veterans


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Genetics

ORG_CITY: Chicago

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Cardiovascular disease (CVD) results in 40% of all deaths and results in serious morbidity in both men and women and it is well known that a key early step in the development of CVD is dysfunction of a thin single-cell layer of cells lining the inner wall of the blood vessels called endothelium. Our goal is to determine the mechanisms responsible for the impairment of endothelial function by hypercholesterolemia, focusing on cholesterol-induced suppression of a specific type of endothelial K+ channel that we showed to play a significant role in endothelial dysfunction. Currently we focus on elucidating the mechanism of how cholesterol binding to the channels impairs their function (a fundamental and still unanswered question), the role of cholesterol-induced suppression of these channels in endothelial dysfunction, and the impact of the loss of function of these channels on atherosclerosis development, which we believe will contribute significantly to the understanding of endothelial dysfunction and provide the basis for new therapeutic approaches.

PI_NAMEs: LEVITAN, IRENA  (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Address;Aorta;Apolipoprotein E;atheroprotective;Atherosclerosis;Binding;Binding Sites;Biochemical;Blood Vessels;Cardiovascular Diseases;Cell Line;Cells;Cessation of life;Cholesterol;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;computer studies;Cytoskeleton;Data;Dependovirus;Descending aorta;Development;Down-Regulation;Dyslipidemias;Electrophysiology (science);Endothelial Cells;endothelial dysfunction;Endothelium;Functional disorder;Funding;gain of function;Gene Expression;Genetic;Goals;Grain;Grant;High Density Lipoproteins;Human;Hydrophobicity;hypercholesterolemia;Impairment;In Vitro;in vivo;Individual;Injury;insight;inward rectifier potassium channel;Ion Channel;KDR gene;Kir2.1 channel;Lesion;loss of function;Low-Density Lipoproteins;Mediating;men;Modeling;Molecular;molecular dynamics;molecular scale;Monomeric GTP-Binding Proteins;Morbidity - disease rate;mouse model;Mus;mutant;Mutation;Neutrons;novel;novel therapeutic intervention;overexpression;PECAM1 gene;Phenotype;Phospholipids;Phosphorylation;PIK3CG gene;Plasma;Play;Potassium Channel;predictive modeling;Process;Proteins;Radiolabeled;Regulation;Research;response;Risk Factors;Role;Signal Transduction;simulation;Site-Directed Mutagenesis;Testing;Thinness;transcriptome sequencing;Transgenic Model;Transgenic Organisms;Translating;Transmembrane Domain;Vasodilation;Woman

PROJECT_TITLE: Cholesterol Regulation of Endothelial K+ Channels

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: HOUSTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative Loss of cardiomyocytes by necrotic cell death is the direct mechanistic basis for mortality due to myocardial infarction injury, as well as ensuing heart failure associated with an array of cardiomyopathies. This proposal will explore novel mechanisms in regards to the composition and regulation of the mitochondria permeability transition pore and its opening, which is the critical event that is responsible for regulated necrotic cell death. Further definition and molecular composition of the permeability transition pore is critical for designing new therapeutic strategies.

PI_NAMEs: KARCH, JASON MICHAEL (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Adenine Nucleotides;Affect;Ants;Binding;Calcium;candidate identification;Cardiac Myocytes;Cardiomyopathies;Cause of Death;Cell Culture System;Cell Death;Cells;Cessation of life;Characteristics;Communities;Compensation;Crista ampullaris;Cyclophilin A;cyclophilin D;Cyclosporine;Data;desensitization;design;Enterobacteria phage P1 Cre recombinase;Event;Excision;Family;Family member;Genetic;Heart;Heart failure;In Vitro;in vivo;inhibitor;Injury;Inner mitochondrial membrane;insight;Ischemia;ischemic injury;Isomerism;Knockout Mice;Laboratories;Liver;Liver Mitochondria;Masks;Measures;Membrane;Membrane Potentials;Membrane Proteins;mimetics;Mitochondria;mitochondrial dysfunction;mitochondrial permeability transition pore;Molecular;mortality;Mus;Mutate;Myocardial Infarction;Myocardial Ischemia;Necrosis;novel;novel therapeutic intervention;Organelles;Outer Mitochondrial Membrane;Oxygen;Peptidylprolyl Isomerase;Permeability;Probability;Production;protective effect;Protein Isoforms;Proteins;Regulation;Reperfusion Injury;Resistance;Role;Rupture;SLC25A4 gene;SLC25A5 gene;Swelling;Therapeutic;therapeutic target;Tissues;Work

PROJECT_TITLE: Molecular Regulation of Mitochondrial Permeability Transition and its Role in Regulated Necrosis

STUDY_SECTION: MIM

STUDY_SECTION_NAME: Myocardial Ischemia and Metabolism Study Section[MIM]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Eye Disease and Disorders of Vision;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease

ORG_CITY: Bloomington

ORG_NAME: HEALTHPARTNERS INSTITUTE

ORG_STATE: MN

PHR: PROJECT NARRATIVE Dr. José Maldonado-Ortiz will evaluate patients with chronic Hepatitis C virus (HCV) infection before and after direct-acting antiviral treatment to determine the pathophysiologic changes in the salivary glands (SG) and correlate those changes to xerostomia and clinical features of salivary dysfunction. Additionally, a mouse model expressing HCV antigenic proteins will be used to better understand the HCV/host immune cell interactions and tissue changes that may result in SG dysfunction. HCV infection, which is the most common blood-borne pathogen in the US and has been associated with dry mouth, offers a unique opportunity to study viral induced SG dysfunction and can provide mechanistic data on the role of viruses in driving inflammation, dysfunction, and damage in the SG.

PI_NAMEs: MALDONADO-ORTIZ, JOSÉ ORLANDO (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: adeno-associated viral vector;Anti-viral Agents;Anti-viral Therapy;Architecture;Autoimmune Diseases;Automobile Driving;Biopsy;Blood-Borne Pathogens;Cell Communication;Cells;Cellularity;Chronic;Chronic Hepatitis;Chronic Hepatitis C;chronic liver disease;Cirrhosis;Clinical;cohort;Cytomegalovirus;Data;Dryness;Duct (organ) structure;env Gene Products;Epithelial Cells;Esthesia;Exhibits;Extrahepatic;Freezing;Functional disorder;Gene Expression Profile;Generations;Genes;Genetic Transcription;genomic RNA;Goals;Guide RNA;health related quality of life;healthy volunteer;Hepatitis C;Hepatitis C Vaccine;Hepatitis C virus;Histologic;Human papillomavirus 16 E1 protein;human pathogen;human tissue;Immune;Immune response;Immunophenotyping;improved;in vivo;Individual;Infiltration;Inflammation;instrument;interest;Lymphocyte;Lymphocytic Infiltrate;Major salivary gland structure;Malignant neoplasm of liver;Measures;Mediating;Mentors;Minor salivary gland structure;Molecular;mouse model;Mus;Oral;Oral health;Parotid Gland;Pathology;Pathway interactions;Patients;Perception;Persons;Phase;Phenotype;Physiological;Physiology;Precipitation;Prevalence;prophylactic;Proteins;Public Health;Quality of life;Reporting;Research;Resolution;response;restoration;Role;Saliva;saliva composition;Salivary;Salivary Gland Diseases;Salivary Gland Tissue;Salivary Glands;Sialadenitis;single-cell RNA sequencing;Sjogren's Syndrome;symptom management;Symptoms;Tissues;transcriptome sequencing;Transgenic Mice;Ultrasonography;vaccine access;Viral;Viral reservoir;Virus;Virus Diseases;Work;Xerostomia

PROJECT_TITLE: Exploring Mechanisms of Hepatitis C Virus-Associated Xerostomia

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: This proposal is to establish the Northern Pacific Global Health Leadership, Education, And Development for Early-career Researchers (NPGH LEADERs) Consortium – a research training program directed by the University of Washington in partnership with the Universities of Hawaii, Michigan and Minnesota with international partnerships in Cameroon, Ghana, India, Kenya, Liberia, Nepal, Peru, Thailand, and Uganda. The goal of this Consortium is to provide outstanding mentored research training to U.S. and LMIC post-doctoral and U.S. pre-doctoral trainees at international partner institutions in order to create the next generation of independent global health scientists and leaders.

PI_NAMEs: DATTA, DIBYADYUTI ;JOHN, CHANDY C.;MOYER, CHERYL A.;PRASAD, SHAILENDRA ;ZUNT, JOSEPH RAYMOND (contact)

PROGRAM_OFFICER_NAME: KATZ, FLORA N

PROJECT_TITLE: NPGH LEADERs - NIA - Omuojine

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(58)-R]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Patient Safety;Physical Activity;Physical Rehabilitation;Rehabilitation

ORG_CITY: Aurora

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE This study seeks to provide large-scale, foundational evidence that high-intensity rehabilitation is effective and can be systematically implemented to improve functional outcomes for patients admitted to skilled nursing facilities following hospitalization. Additionally, this study will generate a descriptive overview of factors that predict implementation success while informing effective implementation strategies for future skilled nursing facilities innovation. Overall, this study is a critical step in advancing clinical practice to establish high-intensity rehabilitation as an effective standard of care in skilled nursing facilities to shift current treatment away from low-intensity, conservative interventions.

PI_NAMEs: STEVENS-LAPSLEY, JENNIFER E. (contact)

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: Activities of Daily Living;Acute;acute care;Address;Admission activity;Adopted;Adoption;Adult;Adverse event;appropriate dose;Behavioral;Cessation of life;Characteristics;Client satisfaction;Clinical;clinical practice;Communities;community setting;Complex;contextual factors;cost effective;Country;Data;deconditioning;Deterioration;disability;Dose;Education;Effectiveness;effectiveness evaluation;Eligibility Determination;Evaluation;Event;experience;functional improvement;Future;Gait speed;Health;Home;hospital readmission;Hospitalization;human old age (65+);implementation context;implementation facilitators;implementation strategy;improved;improved outcome;indexing;innovation;insight;Institutionalization;Instruction;Intervention;Length of Stay;Long-Term Care;Maintenance;Measures;Medical;Methods;muscle strength;Musculoskeletal;Nursing Homes;nursing skill;older adult;Outcome;Patient Admission;Patient Discharge;Patient-Focused Outcomes;Patients;Phase;Physical activity;Physical Function;Physical Performance;Physiological;poor communities;Population;pragmatic randomized trial;pragmatic study;Predictive Factor;pressure;primary endpoint;primary outcome;Process;provider adoption;Quality of Care;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;readmission rates;rehabilitation paradigm;rehabilitation strategy;Rehabilitation therapy;rehabilitative care;Resistance;resistance exercise;Site;Skeletal Muscle;Skilled Nursing Facilities;standard of care;Standardization;success;theories;Therapeutic;Time;Training;treatment as usual;trial design;Variant;Work

PROJECT_TITLE: Advancing Rehabilitation Paradigms for Older Adults in Skilled Nursing Facilities

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: SAN JUAN

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: PROJECT SUMMARY: The major goal of this administrative supplement application for the Parent P40 Grant of the Caribbean Primate Research Center (CPRC) is to renovate the Behavioral/Environmental Enrichment Unit (BEEU) area at the Sabana Seca Field Station. This in turn is essential to support animal well-being as well as any future expansion of the Center's Indian origin rhesus macaque colony. It is well-known that species-specific plans for housing and management should be developed in any NHP facility. Such plans should also include strategies for environmental enrichment. The CPRC is one of the most important national resources for any research program using indian- origin (IO) rhesus macaques with no history of admixture and with well-defined genetic and virological backgrounds. Since 1938, the Center has supplied the scientific community with Indian origin rhesus macaques with known backgrounds and of the same genetic pool for use in studies of basic biology and diseases. In the last three years (2020-2023), 1,234 animals have been allocated from the CPRC program in support of NIH-high priority HIV/AIDS-research, mainly R01, P01, U01- funded academic investigators and NIAID-DAIDS-SVEU programs in USA. The CPRC has vast experience in the establishment and maintenance of rhesus macaque breeding colonies. The animal care and use program of the CPRC is in compliance with the directives established by the Animal Welfare Act (AWA), PHS and other agencies. The Center is AAALAC fully- accredited. The population management program has been designed to optimize the health and well-being of the monkeys, enhance the value of the colony for research, and provide healthy animals to the scientific community for a variety of studies. The Center is in the urgent need of renovating the behavior /environmental enrichment infrastructure severely affected by Hurricane Maria. This renovation will support the CPRC's plan for future expansion as well as the parent grant's objective of producing and distribute valuable genetically and virologically characterized rhesus monkeys for the research community.

PI_NAMEs: BURGOS-RODRIGUEZ, ARMANDO GIL;MARTINEZ, MELWEEN I. (contact);SARIOL, CARLOS A

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: Accreditation;Acquired Immunodeficiency Syndrome;Administrative Supplement;Admixture;Affect;animal care;animal facility;Animal Welfare Act;Animals;Area;Behavior;Behavioral;Biology;Biomedical Research;Breeding;Caribbean region;Cementation;Communities;Coupled;Dengue;design;Deterioration;Development;Disease;Elements;Ensure;Environment;environmental enrichment for laboratory animals;experience;Funding;Future;Genetic;germ free condition;Goals;Grant;Health;Health Promotion;HIV/AIDS;Housing;Human;Hurricane;Infrastructure;insight;Macaca;Macaca mulatta;Maintenance;Modernization;Monkeys;National Institute of Allergy and Infectious Disease;nonhuman primate;Ophthalmology;Outcome;parent grant;parent project;Parents;Pattern;Personal Satisfaction;Play;Population;Practice Management;Primates;Production;programs;Recording of previous events;Regulation;Research;research and development;Research Personnel;Research Priority;Resources;Role;therapeutic development;Tooth Diseases;United States National Institutes of Health;ZIKA

PROJECT_TITLE: Caribbean Primate Research Center Program


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes

PHR: Project Narrative Diabetes mellitus is a major cause of morbidity and mortality in the United States and research by a new generation of investigators is required to more effectively prevent and treat diabetes. This program will provide intensive post-doctoral training in diabetes research for MD and PhD trainees in a highly collaborative, multidisciplinary environment that promotes diversity at the University of Illinois at Chicago, the largest university in the Chicago area.

PI_NAMEs: UNTERMAN, TERRY G. (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Diabetes Mellitus;Research Training;Training Programs

PROJECT_TITLE: UIC Diabetes Research Training Program

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Genetics;Health Services;Human Genome;Mental Health;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE This project investigates the impact of disclosing genetic risk information on parental behavior and psychological responses in managing childhood obesity. By conducting interviews with parents and caregivers who have received genetic risk assessments for their children, the study aims to understand how this information affects health behavior changes, including a range of psychosocial issues. The findings will guide the developing of effective, ethically informed practices in genetic counseling and healthcare, enhancing interventions to prevent childhood obesity.

PI_NAMEs: HAKONARSON, HAKON  (contact)

PROGRAM_OFFICER_NAME: ROWLEY, ROBB KENNETH

PROJECT_TERMS: Address;Adopted;Affect;Anorexia;Anxiety;Asthma;Behavior;behavior change;Behavioral;Body mass index;Caregivers;Caring;Child;Child health care;Child Mental Health;Childhood;Classification;Clinic;Clinical;cohort;Communication;Complex;Computerized Medical Record;Data;Development;Diet;diet and exercise;Disclosure;effective intervention;Effectiveness;Electronic Health Record;Electronic Medical Records and Genomics Network;Ethics;experience;Family;Feeling;Food;Fostering;Funding;Genetic Counseling;genetic information;Genetic Risk;genetic risk assessment;Genomics;global health;Guidelines;Guilt;Health;Health behavior;Health behavior change;Health Personnel;Health Promotion;Healthcare;healthy weight;high risk;high risk population;improved;innovation;insight;Intention;interest;Intervention;Interview;Joints;Medical center;Methods;Non obese;Non-Insulin-Dependent Diabetes Mellitus;novel;nutrition;Obesity;obesity in children;obesity prevention;obesity risk;obesity treatment;Outcome;overweight child;parent project;Parents;Participant;Pediatric cohort;Pediatric Hospitals;Perception;Philadelphia;polygenic risk score;Population Heterogeneity;Predisposition;prevent;Prevention;Process;programs;Protocols documentation;Provider;psychologic;psychological distress;Psychological Impact;psychosocial;Psychosocial Influences;Recommendation;Recording of previous events;recruit;Reporting;Research;response;Risk;Risk Assessment;Risk Factors;Risk Reduction;Role;Self-control as a personality trait;Site;Social Behavior;Social Interaction;social stigma;Structure;Subgroup;Translating;Trauma;type I and type II diabetes;United States;Variant;Weight

PROJECT_TITLE: eMERGE 4 Obesity Supplement


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: COLLEGE PARK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: PROJECT NARRATIVE Children from disadvantaged backgrounds, on average exhibit disparities in academic achievement and cognitive development, compared to their peers from higher socioeconomic status (SES) backgrounds. The proposed studies will investigate the role of specific aspects of children’s early language input on the development of neural networks supporting the development of language, executive functioning, and social cognition, and how these may ultimately drive SES differences in academic achievement. Findings from this work have the potential to inform maximally impactful interventions to reduce achievement gaps and improve cognitive outcomes for children from all backgrounds.

PI_NAMEs: ROMEO, RACHEL RENE (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: Academic achievement;Achievement;Affect;Affective;Age;Area;Award;Brain;career;Child;Child Language;Childhood;Cognitive;cognitive development;cognitive neuroscience;cognitive skill;cohort;Complex;critical period;Data;Data Collection;Development;disadvantaged background;Disparity;early adolescence;early experience;elementary school;Environmental Risk Factor;executive function;Exhibits;Exposure to;flexibility;Home;improved;Income;Inferior;innovation;Intervention;Investigation;kindergarten;Knowledge;Language;Language Development;Left;Linguistics;Link;Longitudinal Studies;low socioeconomic status;Mediating;Methodology;Modeling;multimodal neuroimaging;multimodality;neural;neural network;Neurocognitive;neurodevelopment;neuromechanism;Neuronal Plasticity;novel;Nursery Schools;Outcome;peer;Phase;Play;Positioning Attribute;prevent;Readiness;Research;research faculty;Role;Sampling;scaffold;Schools;Shapes;Short-Term Memory;skills;social;social cognition;Social Development;social factors;socioeconomic disparity;Socioeconomic Status;Structure;success;support network;Support System;Surface;syntax;System;Techniques;Testing;theory of mind;Thick;Time;Training;white matter;Work

PROJECT_TITLE: Language Input as a Mechanism Underlying Socioeconomic Disparities in Neurocognitive Development

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Bioengineering;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Epilepsy;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Due to neurovascular coupling, neural activity creates a reliable increase in blood flow and hence local temperature, which can be measured in the operating room with an infrared thermographic camera. While an awake patient performs tasks, this new method of monitoring the patterns of temperature fluctuation can be used to create a map of brain function, that once validated the surgical team can use to avoid damage to key functional areas. This can lead to safer, faster, and more effective surgeries for patients with drug-resistant epilepsy, glioma, or neurovascular malformations.

PI_NAMEs: PARRISH, TODD B (contact);TATE, MATTHEW CHRISTOPHER

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Agreement;Area;arm;Articulation;awake;Behavioral;Blood flow;Blood Vessels;Brain;brain based;Brain Mapping;Brain region;Cerebral cortex;Computer software;Computers;Contralateral;Craniotomy;Data;Electric Stimulation;Epilepsy;Excision;Functional Magnetic Resonance Imaging;Glioma;haptics;hemodynamics;Image;improved;Intractable Epilepsy;Language;malformation;Maps;Measures;Metabolism;Methods;Modeling;Monitor;Motor;Motor Cortex;multitask;neural;Neurologic Deficit;neurosurgery;neurovascular;neurovascular coupling;Operating Rooms;Operative Surgical Procedures;Patient-Focused Outcomes;Patients;Pattern;Physiological;Postoperative Period;Procedures;Property;Protocols documentation;Resolution;response;Risk;Safety;Seizures;Sensory;Signal Transduction;Stimulus;Surface;synergism;System;Temperature;Testing;Thermodynamics;Thermography;Time;tumor;wireless

PROJECT_TITLE: Diversity Supplement for Tran: High-resolution Infrared Thermal Imaging (ITI) for Simultaneous Functional Mapping of the Entire Craniotomy in Awake Patients


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Genetics

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

PHR: NARRATIVE Transcription is the first step in gene expression, is the most highly regulated step in gene expression, and is the target of two classes of current antibacterial drugs. Bacterial and archaeal transcription initiation and transcription elongation are well understood, but bacterial and archaeal transcription termination are only poorly understood. The proposed work will define the structural and mechanistic basis of the principal pathways of bacterial and archaeal transcription termination.

PI_NAMEs: EBRIGHT, RICHARD H. (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Address;Administrative Supplement;Anti-Bacterial Agents;antitermination;Archaea;Bacteria;Cleavage And Polyadenylation Specificity Factor;Complex;Cryoelectron Microscopy;deep sequencing;DNA;Endoribonucleases;Escherichia coli;Exoribonucleases;Gene Expression;Genetic Transcription;Invaded;Mediating;Modeling;nanopore;Pathway interactions;Pharmaceutical Preparations;protein protein interaction;Proteins;Regulation;Resolution;rho;RNA;single molecule;Structure;Testing;Thermococcus;Transcription Elongation;Transcription Initiation;transcription termination;Transcriptional Regulation;translocase;Work

PROJECT_TITLE: Prokaryotic Transcription Termination, Administrative Supplement

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: EL PASO

ORG_NAME: TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER AT EL PASO

PHR: Project narrative  MicroRNAs (miRNAs) enrichment was detected at synapse and synaptosomal components; however, the status of synaptosomal miRNAs and their precise roles in Alzheimer's disease progression are completely unexplored. Present study is designed to determine the status of synaptosomal and cytosolic miRNAs in Alzheimer's disease and to unveil their possible roles in amyloid-β and p-tau induced synaptic damage and cognitive dysfunction. The outcome of our study is expected to provide new insights about synaptosome- specific miRNAs and their therapeutic relevance in synaptic dysfunction in Alzheimer's disease.

PI_NAMEs: KUMAR, SUBODH  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Age;Alzheimer's Disease;Alzheimer's disease brain;Amyloid beta-Protein;Autopsy;base;Behavior;Behavioral;Biochemical;Brain;brain control;Cognitive;cognitive function;Complementary DNA;Complex;Data Analyses;Dendritic Spines;design;Development;differential expression;Disease Progression;frontal lobe;Functional disorder;Genes;Genomics;Goals;Hippocampus;Impaired cognition;improved;In Vitro;inhibitor;insight;Knockout Mice;Lead;Link;Mediating;Messenger RNA;Microarray Analysis;MicroRNAs;miRNA expression profiling;Mitochondria;Molecular;Mus;mutant;Neurodegenerative Disorders;neuronal growth;Neurons;neurotransmission;Neurotransmitter Receptor;Neurotransmitters;Outcome;Outcome Study;Pathogenesis;Pathology;Physiological;postsynaptic;postsynaptic density protein;presynaptic;Process;Property;Protein Biosynthesis;Proteins;Proteomics;Publishing;Quantitative Reverse Transcriptase PCR;Regulation;Reporting;Research;RNA;Role;Signal Transduction;Small RNA;Synapses;synaptic function;Synaptic plasticity;Synaptic Vesicles;Synaptosomes;tau mutation;tau Proteins;tau-1;Testing;Therapeutic;therapeutic miRNA;Toxic effect;Transcript;transcriptome sequencing;Transfection;Transgenic Organisms;United States National Institutes of Health;Wild Type Mouse

PROJECT_TITLE: Synaptosomal MicroRNAs, Synaptic Damage and Cognitive Decline in Alzheimer's Disease


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: TROY

ORG_NAME: RENSSELAER POLYTECHNIC INSTITUTE

PHR: Project Narrative The heart is left-right asymmetric with its apex pointing towards the left. Deviation from such an asymmetry leads to severe congenital malformations and has significant clinical implications. Here we propose to study the role of cell handedness in the establishment of left-right asymmetry during cardiac development.

PI_NAMEs: WAN, LEO Q. (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: 3-Dimensional;Actins;alpha Actinin;Animal Genetics;Animal Model;Anterior;Apical;Apoptosis;Biochemical;Biological Assay;biomechanical model;Biomechanics;biophysical analysis;Biophysical Process;Biophysics;Cadherins;Cardiac;cardiogenesis;Cell Differentiation process;Cells;Chemicals;Chick;Clinical;Congenital Abnormality;congenital heart abnormality;crosslink;Crosslinker;cytokine;Cytoskeleton;Defect;Development;Dextrocardia;directional cell;Double Outlet Right Ventricle;Drosophila genus;Embryo;embryo culture;Embryonic Heart;Event;Exhibits;experimental study;fascin;Fetal Death;Genetic;Genitalia;Handedness;Heart;high throughput screening;Hindgut;Human;Hydrogels;In Vitro;in vitro Model;Infant;inhibitor;interest;kinase inhibitor;Left;Libraries;Literature;Live Birth;live cell imaging;Measures;mechanical force;Microfabrication;Molecular;Morphogenesis;Morphology;mouse model;Myocardium;Myosin Type II;Nature;Nodal;novel;Organ;Outcome;Pattern;Pharmaceutical Preparations;Phenotype;Phosphotransferases;Population;Property;Protein Isoforms;Protein Kinase C;Research;Role;Rotation;Scaffolding Protein;screening;septal defect;Shapes;Side;Signal Pathway;Signal Transduction;small molecule;small molecule inhibitor;Structure;Surface;System;Technology;Teratogens;Tissues;tool;Traction Force Microscopy;Translating;Tube;Vertebrates;Visceral;Work

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


NIH_SPENDING_CATS: Infectious Diseases;Sleep Research

ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE My lab studies circadian-regulated processes and their contributions to health and disease; circadian regulation refers to daily oscillations in biological functions (e.g., metabolism, sleep) and is a universal, evolutionarily conserved feature from bacteria to humans. Proper circadian regulation is important for human health; despite the profound effects of circadian regulation on human health and physiology, it remains unclear how loss of circadian regulation contributes to the progression of disease (i.e., metabolic disorders, bacterial infection). In this proposal, we focus on circadian-regulated metabolism in Drosophila and its role in sensitivity to oxidative stress due to chronic short sleep (Project 1) and regulation of host tolerance of bacterial infection (Project 2).

PI_NAMEs: SHIRASU-HIZA, MICHELE M (contact)

PROJECT_TERMS: Bacteria;Bacterial Infections;Behavioral;Biological Process;Burkholderia cepacia;Chronic;circadian;Circadian Dysregulation;circadian pacemaker;circadian regulation;Circadian Rhythms;Data;Defect;Defense Mechanisms;Disease;Disease Progression;Drosophila genus;Feedback;Funding;Genes;Genetic Transcription;Health;Hour;Human;Immunity;Infection;Innate Immune Response;Investigation;Jet Lag Syndrome;Knowledge;lipid metabolism;Mammals;Mediating;Metabolic;Metabolic Diseases;Metabolism;Mus;mutant;National Institute of General Medical Sciences;Natural Immunity;Nervous System Disorder;Oxidative Stress;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Physiological;Physiology;Process;Publishing;Regulation;Research;Resistance;resistance mechanism;Rest;Role;shift work;Sleep;Stimulator of Interferon Genes;Tissues;tool development;Work

PROJECT_TITLE: Circadian regulation of physiological functions


NIH_SPENDING_CATS: Autoimmune Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lupus;Machine Learning and Artificial Intelligence;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PI_NAMEs: SHEIKH, SAIRA Z (contact)

PROGRAM_OFFICER_NAME: ANWAR, MOHD MOZHARUL

PROJECT_TERMS: Affect;aggressive therapy;Autoimmune Diseases;black women;Clinical;Data;Data Sources;design;Diagnosis;Diagnostic;Diagnostic tests;Disease;Early Diagnosis;Electronic Health Record;Ethics;experience;Health;health equity;High Prevalence;Hispanic Women;Image;Instruction;Learning;Left;Life;Lupus;Measures;Modality;model design;Modeling;Monitor;multimodal learning;multimodal modeling;multimodality;Organ;Outcome;Patients;Persons;Population;Recommendation;Research;Research Project Grants;rheumatologist;Risk;Specialist;Symptoms;Systemic Lupus Erythematosus;Technology;Training;Woman

PROJECT_TITLE: Unified and fair multimodal representation learning for autoimmune diseases


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurosciences;Opioids;Pain Research;Substance Misuse

ORG_CITY: MIAMI

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE The prevalence of chronic widespread pain in individuals infected with the human immunodeficiency virus-1 (HIV-1) is high, ranging from 25% to 85%. Despite the increasing awareness that pain is a significant problem for people with HIV by the International Task Force on Pain and AIDS in 1994, the prevalence rate of pain since the 1980s has not diminished despite antiretroviral therapy. Therefore, in this study, we propose to identify the mechanisms of chronic widespread pain in HIV and identify non-opioid therapeutic interventions to mitigate pain.

PI_NAMEs: AGGARWAL, SAURABH  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Absence of pain sensation;Acquired Immunodeficiency Syndrome;addiction;Address;Advisory Committees;Analgesics;Antioxidants;antiretroviral therapy;Apoptosis;Attenuated;Awareness;Behavior;behavior measurement;beta-Endorphin;Binding;Blood;Blood specimen;Bromides;CD4 Lymphocyte Count;Cells;Chronic Disease;chronic inflammatory disease;chronic pain;chronic widespread pain;Clinical;comorbidity;Coupled;cytokine;disability;Disease;Dynorphin A;endogenous opioids;Endoplasmic Reticulum;endoplasmic reticulum stress;experimental study;Failure;Functional impairment;Genetic;Heme;heme a;Hemolysis;Hemopexin;HIV;HIV Infections;HIV Seronegativity;HIV-1;Homeostasis;Hyperalgesia;Hypersensitivity;Impairment;improved;Individual;Infection;Inflammatory;inhibitor;Injections;innovation;International;Knowledge;Leukocytes;Life Expectancy;Link;Lymphocyte;Macrophage;Measures;Mediating;Methionine Enkephalin;Modeling;monocyte;Mus;Musculoskeletal Pain;Nature;neuroAIDS;Neurons;Neuropathy;neutrophil;Nociception;non-opioid analgesic;Nonpharmacologic Therapy;novel;Opioid;Opioid Antagonist;Opioid Peptide;Opioid Receptor;Overdose;Pain;pain sensitivity;Pathogenesis;Patient Self-Report;Patients;Peptide Synthesis;Peripheral;Persons;pharmacologic;Phenotype;Plasma;potential biomarker;pre-clinical;Predisposition;Prevalence;prevent;Proteins;Quality of life;Rat Transgene;Rattus;Research;Resolution;Role;Sensory;Source;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;TLR4 gene;Viral Load result;Work

PROJECT_TITLE: Chronic Widespread Pain in HIV: Novel Mechanisms and Therapeutics

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Diabetes;Microbiome;Nutrition;Obesity

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Excessive visceral adiposity, also known as central obesity, predicts development of type 2 diabetes and other metabolic diseases. We have recently identified Clostridium immunis as a commensal bacterium—and a sugar it secretes as the relevant active molecule—that reduces visceral adiposity, and the proposed studies seek to understand the mechanisms by which this happens. These results will highlight new therapeutic opportunities for reducing visceral adiposity and treating metabolic diseases.

PI_NAMEs: SURANA, NEERAJ K (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: adipokines;Adipose tissue;Anabolism;Behavioral;blood glucose regulation;Body Weight;Cells;Central obesity;Chronic;Clinical Trials;Clostridium;commensal bacteria;comparison control;Data;Development;Diet;Disease;disease model;energy balance;Energy Metabolism;Environment;experimental study;fatty acid metabolism;Future;Genes;Goals;Health;High Fat Diet;Human;human data;Hypertriglyceridemia;Immune;Immune response;Immune system;Immunologics;Immunophenotyping;immunoregulation;Impairment;improved;Individual;Inflammatory;insight;Insulin Resistance;insulin sensitivity;insulin signaling;interleukin-22;Knowledge;Leptin;Link;lipid metabolism;Lymphoid Cell;Mediating;Metabolic;metabolic abnormality assessment;Metabolic Diseases;metabolic phenotype;Metabolic syndrome;Metabolism;Metagenomics;Microbe;microbiome;microbiome therapeutics;microbiota;Mus;mutant;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutics;Obesity;obesity management;Oral Administration;Persons;Phosphorylcholine;Physiological;Play;Probiotics;Process;Recommendation;Regulation;resistin;Risk Factors;Role;Serum;sugar;Testing;Text;Therapeutic;trait;trend;Triglycerides;Visceral;Work

PROJECT_TITLE: Regulation of metabolic diseases by Clostridium immunis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-D(02)M]


ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Our recent work has identified a surprising level of parallel molecular responses among different cell types in the pituitary gland, the master controller of the endocrine system. We will now study mechanisms underlying regulation of the follicle stimulated hormone gene, a key gene involved in reproduction and polycystic ovarian disease, as well as the molecular changes in endocrine cell types in the pituitary during the reproductive cycle and during the development of hypothyroidism. The use of techniques for comprehensive study of the molecular state of individual cells will improve understanding of the pituitary endocrine processes contributing to health and disease.

PI_NAMEs: SEALFON, STUART C. (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Activins;Acute;Alternative Splicing;Anabolism;ATAC-seq;autocrine;Bioinformatics;Cell Physiology;cell type;Cells;Chromatin;Codependence;Communities;Competence;Complex;Data;Data Set;Development;Disease;Endocrine;Endocrine system;Epigenetic Process;Estrous Cycle;experimental study;Feasibility Studies;Female;female fertility;Follicle Stimulating Hormone;Formulation;Foundations;Freezing;Gene Expression;Gene Expression Regulation;gene regulatory network;Generations;Genes;Genetic Transcription;GNRH1 gene;Health;Hormonal;Human;hypothalamic pituitary gonadal axis;Hypothyroidism;improved;in vivo;Individual;insight;Logic;male;Manuscripts;Mediating;Messenger RNA;Methods;Molecular;mouse model;Mus;Neurosecretory Systems;paracrine;Pattern;Physiological Processes;Physiology;Pituitary Diseases;Pituitary Gland;Polycystic Ovary Syndrome;Preparation;Probability;Process;programs;promoter;Regulation;Regulator Genes;Reproduction;reproductive;Research;Research Personnel;Resolution;response;Role;sex;Signal Transduction;Site;Spliced Genes;Stimulus;System;Systems Biology;Techniques;Testing;Tissue-Specific Gene Expression;transcriptome;transcriptome sequencing;Transforming Growth Factor beta;Work

PROJECT_TITLE: Integrated systems biology of the pituitary

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Sexually Transmitted Infections;Vaccine Related

ORG_CITY: BILTHOVEN

ORG_COUNTRY: NETHERLANDS

ORG_FIPS: NL

ORG_NAME: INTRAVACC B.V.

PI_NAMEs: OOSTERHOFF, DINJA  (contact)

PROJECT_TERMS: Advanced Development;Animal Model;Antibiotic Resistance;Bacterial Drug Resistance;bacterial resistance;biodefense;Clinical;Combating Antibiotic Resistant Bacteria;Communicable Diseases;Contracts;Disease Outbreaks;efficacy evaluation;efficacy testing;Emerging Communicable Diseases;Formulation;immunogenicity;Individual;manufacture;Neisseria gonorrhoeae;response;Safety;stability testing;Toxicology;vaccine candidate;vaccine development;Vaccines

PROJECT_TITLE: Advanced Development of Vaccine Candidates for Biodefense and Emerging Antibiotic-Resistant Infectious Diseases


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases;West Nile Virus

ORG_CITY: KENSINGTON

ORG_NAME: ADVANCED BIOSCIENCE LABORATORIES, INC.

PI_NAMEs: FOUTS, TIM  (contact)

PROJECT_TERMS: Adjuvant;Biological Products;Clinical Research;Communicable Diseases;Contracts;Cyclic GMP;Development;Development Plans;manufacture;novel vaccines;Phase;product development;Services;System;United States Food and Drug Administration;vaccine delivery;vaccine development;Vaccines;West Nile virus

PROJECT_TITLE: Task V30: GMP Manufacturing of WNV Vaccine


ORG_CITY: ALBANY

ORG_NAME: ALBANY MOLECULAR RESEARCH, INC.

PI_NAMEs: ALLARD, MELISSA  (contact)

PROJECT_TERMS: clinical pain;clinical trial readiness;Clinical Trials;Feasibility Studies;Formulation;Good Manufacturing Process;Helping to End Addiction Long-term;manufacture;Pain;Pain management;Pharmaceutical Preparations;programs;Speed;United States National Institutes of Health

PROJECT_TITLE: FEASIBILITY STUDIES, CLINICAL TRIAL READINESS, GMP/CLINICAL TRIAL MATERIALS


FUNDING_MECHANISM: INTERAGENCY AGREEMENTS

NIH_SPENDING_CATS: Dietary Supplements;Health Effects of Indoor Air Pollution;Natural Products;Prevention

ORG_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

PHR: Characterizing occupational exposures provides a real-world context for NIEHS toxicology studies. To achieve this, NIOSH will characterize occupational exposures using a multidisciplinary approach to include toxicology, epidemiology, engineering, industrial science, and occupational medicine. These studies contribute to the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents by identifying sources of exposure and strategies for mitigation.

PROJECT_TERMS: academic review;Acute;Adverse effects;Agreement;Air;Beverages;Biological;Blood;Cannabis;Carbon;carcinogenicity;Chemicals;Citrus;Collection;Communication;Complement;consumer product;Databases;Dermal;Diffusion;disorder prevention;Engineering;Enhancers;Ensure;Environmental Exposure;Epidemiology;European;Exhalation;Exhibits;Exposure to;Eye;Flavoring;Food;Frequencies;Goals;Government Officials;Hazard Assessment;Hazard Identification;Health;Herb;Human;Humulus;Hydrogen;Hypersensitivity;in vivo;Industrialization;Industry;interdisciplinary approach;interest;Investigation;irritation;Literature;Lung;manufacture;Methods;Monoterpenes;National Institute of Environmental Health Sciences;Nose;Occupational;Occupational Exposure;Occupational Groups;Occupational Medicine;Oxides;Perfume;Pharyngeal structure;Plants;Population;Production;Protocols documentation;Reporting;Research Personnel;Sampling;Science;Sensory;Services;Site Visit;Source;Toxicology;Trees;Turpentine;Universities;Urine;volatile organic compound;Wood material

PROJECT_TITLE: Occupational Exposure Assessment of alpha-Pinene and related Monoterpenes


ORG_CITY: MINNEAPOLIS

ORG_NAME: MINNEAPOLIS VA  MEDICAL CENTER

PHR: For Veterans with spinal cord injury who use a wheelchair, pressure injuries related to sitting are a significant daily threat to well-being. Pressure injuries are costly to treat, negatively impact quality of life and community participation, and can be life threatening. Moving or shifting at regular intervals in the wheelchair redistributes harmful pressure and reduce risk for skin breakdown, yet these movements are a challenge to perform consistently. The challenge exists due to lack of sensation to let the individual know they need to shift their weight. Pressure mapping provides a detailed visual representation of pressure distribution and can compensate for impaired sensation. Pressure mapping feedback delivered on-demand on mobile platforms can potentially increase effectiveness in carrying out behaviors to reduce risk for pressure injury when used during clinician-delivered education to set goals and monitor progress and when used at home as a self- management strategy.

PI_NAMEs: EDDY, BYRON W (contact)

PROJECT_TERMS: actigraphy;Acute;Adult;Area;Beds;Behavior;Belief;Cellular Phone;Charge;Chest;Clinical;Community Participation;community setting;Compensation;Computer software;cost;Cues;Data;decubitus ulcer;design;Development;Disease;Docking;Education;education planning;Educational process of instructing;Effectiveness;Ensure;Esthesia;Evaluation;experience;Feedback;Focus Groups;Fostering;Frequencies;Funding;Goals;Health;Healthcare Systems;Home;Hospitals;Hypesthesia;improved;Individual;injured;Injury;injury prevention;Inpatients;Intervention;Interview;Learning;Life;Manual wheelchair;Maps;Measures;meetings;Methods;mobile computing;Monitor;Motor;Movement;Nurses;Observational Study;Outcome;Outpatients;Paralysed;Patient Education;Patients;Performance;Personal Satisfaction;pilot test;Positioning Attribute;Powered wheelchair;preference;pressure;prevent;Prevention;Prevention education;Quality of life;Questionnaires;real-time images;Rehabilitation therapy;Research Design;Risk Factors;Risk Reduction;Risk Reduction Behavior;Self Efficacy;Self Management;Site;Skin;Skin Care;smart watch;smartphone based assessment;Spinal cord injury;Standardization;success;Surface;Surveys;System;Systems Development;Testing;Time;tool;Training;Translations;United States Department of Veterans Affairs;Update;usability;Veterans;Visit;Visual;Visualization;Weight;Wheelchair user;Wheelchairs

PROJECT_TITLE: Refinement of the Comprehensive Mobile Assessment of Pressure (CMAP) System for Prevention of Pressure Injuries

STUDY_SECTION_NAME: Rehabilitation Engineering & Prosthetics/Orthotics [RRD5]


ORG_CITY: ANN ARBOR

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: MI

PHR: Project Narrative Noise exposure during their military careers and over their lifetimes could be an unrecognized but significant factor in vestibular disorders prevalent in aging Veterans. A recent study found that ~69 million US adults over the age of 40 have a balance disorder involving the inner ear and many of these patients also suffer from noise induced or occupational hearing loss. The proposed experiments will characterize noise induced vestibular dysfunction in an animal model, a necessary first step for development of preventative and rehabilitative strategies for this population.

PI_NAMEs: ALTSCHULER, RICHARD  (contact)

PROJECT_TERMS: Acceleration;Accidents;Action Potentials;active duty;Address;Adult;Age;age related;Aging;Air;Aircraft;Animal Model;Attenuated;attenuation;Audiology;Auditory;auditory threshold shift;Axon;Behavior;behavioral impairment;career;Cells;Cessation of life;Clinical;cochlear synaptopathy;Complex;Data;Development;equilibration disorder;Equilibrium;Evoked Potentials;excitotoxicity;experience;experimental study;Explosion;Exposure to;fall risk;falls;Frequencies;Functional disorder;gaze;Goals;Grant;Hair Cells;Head;Health;Hearing;hearing impairment;Helicopter;hidden hearing loss;Human;Impairment;insight;Labyrinth;Lead;Life;Locomotion;Loudness;Military Personnel;military service;Mobility decline;Modeling;Movement;Musculoskeletal Equilibrium;Nature;Neck;Noise;noise exposure;Noise-Induced Hearing Loss;Occupational;older adult;Patients;Pattern;Performance;Peripheral;Pharmaceutical Preparations;Physiology;Population;posture instability;preservation;Public Health;Publishing;Quality of life;Rattus;Recovery;Reflex action;Rehabilitation therapy;Reporting;Research;response;Risk Factors;Sensory;Services;Signal Transduction;sound;Stains;Synapses;Temporary Threshold Shift;Time;time use;United States;Vestibular Diseases;Vestibular dysfunction;Vestibular loss;Vestibular Nerve;vestibular reflex;vestibular system;vestibulo-ocular reflex;Veterans;Vision;Visual;Visual Acuity

PROJECT_TITLE: Intense Noise Exposure Impacts Performance of Vestibular Dependent Behaviors

STUDY_SECTION_NAME: Sensory Systems & Communication Disorders[RRD3]


PHR: Reducing Veteran suicide has been the top clinical priority of the VA for the last few years. However, the total number of suicides among Veterans has continued to increase. There is a critical need for targeted treatments to reduce the risk of suicide in Veterans. Impaired executive function, such as impaired decision making and impulsivity, has been identified as an important contributor to the transition from suicidal ideation to suicide attempt. To address the epidemic of Veteran suicide in the United States, we propose to test the feasibility, acceptability, and preliminary effectiveness of a five day transcranial direct current stimulation (tDCS) augmented executive functioning training intervention. This intervention will be delivered to high suicide risk inpatients who have been hospitalized following a suicide attempt. The ultimate goal is to reduce future suicide events (ideation, attempts, deaths) and improve quality of life (e.g. social relationships, health resource utilization).

PI_NAMEs: GILMORE, CASEY S (contact)

PROJECT_TERMS: Acceleration;acceptability and feasibility;Address;Admission activity;Behavior Therapy;Benchmarking;Brain;Cessation of life;Clinical;Cognitive;cognitive training;Confidence Intervals;Controlled Clinical Trials;cost;Data;Decision Making;Ecological momentary assessment;Educational Intervention;Effectiveness;Effectiveness of Interventions;effectiveness testing;Epidemic;Event;Executive Dysfunction;executive function;Exercise;experience;feasibility testing;Feedback;Feeling suicidal;follow-up;Follow-Up Studies;Future;Goals;Health Resources;Healthcare Systems;help-seeking behavior;high risk;Hospitalization;Hospitals;ideation;Impairment;improved;Impulsivity;Inpatients;Intervention;intervention effect;Interview;Learning;Measures;Methods;military veteran;neuroregulation;Participant;Patients;Performance;Persons;pilot trial;Population;Prevention program;psychiatric inpatient;Quality of life;Questionnaires;Randomized;Recording of previous events;recruit;reducing suicide;Research;retention rate;Risk;Risk Reduction;Safety;satisfaction;Services;social relationships;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;Surveys;Task Performances;Technology;Time;Training;transcranial direct current stimulation;United States;Veterans;Visit

PROJECT_TITLE: Effects of Neuromodulation and Cognitive Training for Suicide in Veterans (ENACTS)

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Tinnitus is the most common service-connected disability among Veterans. Despite the prevalence of tinnitus, interventions known to improve quality of life with tinnitus are unstandardized and not widely implemented across VA settings. In contrast to the difficulty many Veterans experience with finding care to improve quality of life with tinnitus, products that falsely claim to cure tinnitus are widely available and easy to access. The purpose of this two-year project is to develop a prototype video-based online module of 10-15 Veterans' narratives on their lived-experience with tinnitus and with seeking assistance for tinnitus in clinical settings and elsewhere. Feedback on the protype will then be gathered from Veterans with bothersome tinnitus. The results will be used to inform the development of a VA Merit Award to create a comprehensive tinnitus module (30-50 narratives) and to evaluate the utility of patient narratives with Veterans and the VA clinicians who serve them.

PI_NAMEs: CLARK, KHAYA DELAINE (contact)

PROJECT_TERMS: Anxiety;Award;Awareness;behavioral health;Caring;Chronic;Chronic Disease;Clinical;clinical practice;Cognitive Therapy;comorbidity;Coping Skills;cost;Data;Databases;Decision Making;design;Development;Devices;disability;Disabling;Drops;Ear;emotional reaction;Evaluation;evidence base;Evidence based treatment;experience;Feedback;Feeling suicidal;Frustration;functional improvement;functional status;Future;Goals;Health;Health Personnel;Health system;Hearing;hearing impairment;help-seeking behavior;improved;Individual;individual patient;information gathering;Internet;Intervention;Interview;Lived experience;Marketing;Mental Depression;Mental Health;Methodology;Methods;military veteran;Oncology;Outcome;Patient Education;patient engagement;Patient-Centered Care;patient-clinician communication;Patients;peer;Persons;physical conditioning;Pilot Projects;Post-Traumatic Stress Disorders;Prevalence;Process;programs;prototype;Provider;Quality of life;recruit;Rehabilitation Outcome;rehabilitation research;rehabilitation service;rehabilitation strategy;Rehabilitation therapy;Reporting;Research;Research Proposals;Rheumatoid Arthritis;Sampling;Self Management;Services;Sleep Disorders;Sleep disturbances;Source;Surveys;Tinnitus;Training;Traumatic Brain Injury;United States Department of Veterans Affairs;uptake;Veterans;video module;Voice;Vulnerable Populations;willingness

PROJECT_TITLE: Patient Health Experiences: Using Patient Narratives to Improve Tinnitus Rehabilitation Services and Outcomes


ORG_CITY: RENO

ORG_NAME: VA SIERRA NEVADA HEALTH CARE SYSTEM

ORG_STATE: NV

PHR: Thiamine micronutrient deficiency (TD) can cause a variety of non-specific symptoms and leads to several thiamine deficiency disorders such as heart failure, polyneuropathy, Wernicke’s Encephalopathy and generalized weakness and debility. Symptoms are often vague and non-specific such as fatigue, leg swelling, imbalance, confusion, mood disorders, gastrointestinal upset, and weakness. Hospitalized veterans may be particularly susceptible to TD due to food insecurity and chronic illnesses which cause inflammation and increased metabolic demands. This study aims to determine the prevalence of TD in hospitalized veterans which has never been done before. We also seek to identify risk factors causing TD including acute and chronic forms of inflammation, food insecurity, and dietary habits. Lastly, we hope to clarify the abnormally low levels of blood thiamine that correlate with symptoms of TD that improve with replenishment.

PI_NAMEs: MATES, ELISABETH  (contact)

PROJECT_TERMS: Activities of Daily Living;Acute;Address;alcohol abuser;Alcohols;Ataxia;Autopsy;Awareness;Biological Assay;Biological Markers;Blood;Cachexia;care costs;Caring;Categories;Chronic;Chronic Disease;Chronically Ill;Clinical;clinically relevant;cofactor;Confusion;Country;Debility;Diagnosis;Dialysis procedure;Diarrhea;Diet Habits;Disease;Diuretics;Economics;Elderly;Encephalopathies;Etiology;Exhibits;experience;Face;falls;Fatigue;Food;food insecurity;functional loss;gastrointestinal;General Population;Goals;Health;healthy volunteer;Heart failure;High Prevalence;Hospitalists;Hospitalization;Hospitals;Hypertension;improved;Incidence;Income;Individual;Inflammation;Inflammatory;Intake;Kidney Failure;Knowledge;Laboratories;Lead;Left;Leg;loss of function;low and middle-income countries;Malabsorption Syndromes;Malnutrition;Measures;Medical;Medicine;Metabolic;micronutrient deficiency;Mission;Mood Disorders;Morbidity - disease rate;Nervous System Physiology;Nested Case-Control Study;Neurologic;neuropsychiatry;non-alcoholic;Normal Range;Nutrient;open label;Outcome;Oxidative Stress;Patient Admission;Patients;Plasma;Polyneuropathy;Population;Populations at Risk;post stroke;Predisposing Factor;Predisposition;Prevalence;Probability;Prospective, cohort study;Publishing;Quality of life;Rehabilitation therapy;Reporting;Research Design;response;Risk;Risk Factors;SARS-CoV-2 infection;Sepsis;severe COVID-19;Signs and Symptoms;social;Stress;Swelling;symptomatic improvement;Symptoms;Syndrome;Testing;Thiamine;Thiamine Deficiency;Time;Toxin;treatment planning;United States;Veterans;Vitamins;Vomiting;Wernicke Encephalopathy;Whole Blood

PROJECT_TITLE: Prevalence of Thiamine Deficiency in Hospitalized Non-Alcoholic Veterans


ORG_CITY: PHILADELPHIA

ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

PHR: Military traumatic brain injury (TBI) is complex, involving both diffuse and focal components and resulting in post- traumatic epilepsy (PTE) in many of our Veterans. While the high incidence of epilepsy following TBI is well known, PTE is often resistant to standard anti-epileptic therapeutics and the mechanisms underlying the transition from trauma to injury are unclear, making new treatment development challenging. Existing rodent models of PTE have reproduced aspects of this progression, including a temporal lobe epilepsy model. However, due to the key role of network localization of hyperexcitability in epileptogenesis, we propose that a large animal model (pig) with a gyrencephalic brain and complex white matter pathways may be the only way to model injury phenotypes and epileptogenesis accurately. We will therefore compare biomarkers and epileptogenic development and mechanisms in two different injury models, cortical contusion and repetitive mTBI. This will allow for treatment target development in order to find and validate new treatment paradigms for PTE.

PI_NAMEs: WOLF, JOHN ALLEN (contact)

PROJECT_TERMS: Address;Algorithms;Animal Model;Animals;anti-epileptic agents;Area;Autopsy;awake;Axon;axon injury;Behavior;Behavioral;behavioral outcome;Biological Markers;Blood;Blood - brain barrier anatomy;Brain;Brain Injuries;Chronic;cognitive task;Complex;controlled cortical impact;Cortical Contusions;Data;Deafferentation procedure;Detection;Development;Diffuse;Electrodes;Electroencephalography;Electrophysiology (science);Epilepsy;epileptiform;Epileptogenesis;Family suidae;Functional disorder;Future;Generalized Epilepsy;Goals;Hippocampus;Image;Implant;Incidence;inhibitory neuron;injured;Injury;Intervention;Investigation;Laboratories;Lead;Location;Measures;mild traumatic brain injury;Military Personnel;Modeling;Monitor;Nerve Degeneration;neurobehavioral;neuroimaging;Neurologic;Neurons;neuropathology;neurophysiology;Outcome;Partial Epilepsies;Pathologic;Pathology;Pathway interactions;Phenotype;Population;Post-Traumatic Epilepsy;Pre-Clinical Model;predictive modeling;Predictive Value;Pregnancy;prevent;Procedures;Process;Prognosis;Prognostic Marker;prognostication;rational design;Resistance;risk stratification;Rodent Model;Seizures;Serum;Sleep;Sleep disturbances;Temporal Lobe Epilepsy;Therapeutic;therapeutic development;therapy design;therapy development;Time;Trauma;Traumatic Brain Injury;Veterans;white matter

PROJECT_TITLE: Chronic Focal and Diffuse Traumatic Brain Injury: Mechanisms Underlying Epileptogenesis and Progressive Dysfunction

STUDY_SECTION_NAME: Brain Health and Injury[RRD1]


ORG_CITY: IOWA CITY

ORG_NAME: IOWA CITY VA MEDICAL CENTER

ORG_STATE: IA

PHR: Parkinson's disease (PD) is an incurable brain illness that afflicts more than one million Americans, including many of our aging veterans. PD places an unbearable burden on the individual due to progressive impairment of movement and mental function. As a result, patients lose critical abilities such as driving and can become isolated. Although drugs and surgery help movement problems, their benefits are temporary and may cause side effects. Drugs provide limited and temporary benefit for cognition and do not prevent dementia. Animal and preliminary human studies on aerobic exercise show promising results in helping a broad spectrum of symptoms. However, due to limited and inconsistent research results, the long term effects of aerobic exercise on brain health and clinical features in PD is unknown. We will conduct a clinical trial to test the long term effects of aerobic exercise on the brain tissue, movement, mental functions, and driving in PD. If effective, aerobic exercise can be implemented immediately as a low cost, easily accessible treatment in PD.

PI_NAMEs: UC, ERGUN Y (contact)

PROJECT_TERMS: Acetylcholinesterase Inhibitors;Activities of Daily Living;Adverse event;Aerobic;Aerobic Exercise;Aging;American;Animals;anti-depressive agents;Automobile Driving;Autonomic nervous system disorders;Biological;Biological Markers;Blood Vessels;Brain;brain health;brain tissue;Cardiac;cardiorespiratory fitness;Cessation of life;Clinical;Clinical Trials;Cognition;Cognitive;cognitive function;Complex;Corpus striatum structure;cost;Data;Dementia;disability;Disease;Disease Progression;exercise regimen;Fatigue;functional outcomes;Health;Human;Immobilization;Impaired cognition;Impairment;improved;improved outcome;indexing;Individual;Individual Differences;Infrastructure;instrumental activity of daily living;Knowledge;Long-Term Effects;Measures;Mediating;Medical;mental function;Metabolic;mild cognitive impairment;Mobility decline;Monitor;Mood Disorders;Motor;motor disorder;motor function improvement;motor impairment;motor symptom;Movement;Nerve Degeneration;neural;non-motor symptom;Operative Surgical Procedures;Outcome;Outcome Measure;Parkinson Disease;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Physical therapy;Physiological Processes;Quality of life;Randomized, Controlled Trials;Research;Research Design;Risk;Sample Size;side effect;Sleep Disorders;societal costs;Structure;Symptoms;System;Testing;Time;Tissues;Training;Translations;treatment as usual;trial comparing;Veterans;VO2max;white matter;Work

PROJECT_TITLE: Long Term Aerobic Exercise to Slow Progression in Parkinson's Disease