ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Eye Disease and Disorders of Vision;Genetics

ORG_CITY: ATLANTA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will build a foundational pathogenic understanding of Sjögren’ss disease (SjD), a common systemic autoimmune disease characterized by oral and ocular dryness and marked morbidity, with no available disease-modifying treatments. This proposal leverages cutting-edge spatial genomic and protein profiling technology to define a new pathologically relevant cell type, the mesenchymal stromal cell, while simultaneously determining clinically relevant differences between salivary gland tissue of seronegative and seropositive SjD subjects. Thus, the proposed research is relevant to the NIDCR’s mission that pertains to improving oral and dental health through research.

PI_NAMEs: COSKUN, AHMET F. (contact);MCCOY, SARA

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Affect;Antibodies;Antigen-Presenting Cells;Atlases;B-Lymphocytes;Bioinformatics;Biomedical Engineering;Biotechnology;CD4 Positive T Lymphocytes;Cell Communication;cell type;Cells;Cellular biology;Chemotaxis;Clinical;clinical phenotype;Clinical Trials;clinically relevant;Collaborations;comparison control;cytokine;Data;design;Diagnostic;Disease;Dryness;economic cost;Ensure;Exclusion;Exocrine Glands;experimental study;FDA approved;Fibrosis;Future;Gene Expression Profiling;Genes;Genetic Transcription;genomic profiling;Genomics;Gland;Goals;health related quality of life;Heterogeneity;High Prevalence;HLA-DR Antigens;Immune;Immunofluorescence Immunologic;Impaired health;improved;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;innovation;insight;International;Labial Salivary Gland;Lymphocyte;Lymphocyte Subset;Lymphocyte Subtypings;Lymphocytic Infiltrate;machine learning classification;mesenchymal stromal cell;Mission;Molecular;Morbidity - disease rate;multiplexed imaging;Myofibroblast;National Institute of Dental and Craniofacial Research;new therapeutic target;novel;Oral;Oral Characters;Oral health;Pathogenesis;Pathogenicity;Pathologic;Pathologist;Pathology;Patients;peer;Peripheral Nervous System;Persons;Phenotype;primary outcome;Process;protein profiling;Proteins;Proteomics;Public Health;Radial;Reaction;Research;rheumatologist;Rheumatology;Role;Salivary Gland Diseases;Salivary Gland Tissue;Salivary Glands;Sampling;Series;seropositive;Signal Transduction;Sjogren's Syndrome;skills;stem cell biology;stem cell therapy;systemic autoimmune disease;T-Cell Activation;T-Lymphocyte;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Intervention;Tissues;Tooth Loss;transcriptomics;translational pipeline;United States;Work

PROJECT_TITLE: Spatial transcriptional phenotyping of Sjögren’s disease tissue-resident mesenchymal stromal cells and neighbors in labial salivary glands

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTOLARYNGOLOGY

ORG_FIPS: US

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The proposed studies address the important areas of breast cancer that is the second leading cause of cancer-related death in women throughout the world, and the regulatory T cell-induced tumor immunosuppressive microenvironment that is a major barrier for successful anti-tumor immunotherapy. The proposed research has relevance to public health, because it seeks to dissect novel suppressive mechanisms and then to develop strategies that control immune suppression mediated by regulatory T cells in human breast cancer. Thus, the findings are ultimately expected to improve treatment of human breast cancer and other cancers as well.

PI_NAMEs: PENG, GUANGYONG  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: adaptive immunity;Address;advanced breast cancer;Affect;anti-PD-1;Area;Breast Cancer Patient;Cancer Etiology;cancer immunotherapy;cancer therapy;Carbon;Cell Aging;Cell Physiology;Cell Senescence Induction;Cells;Cellular Metabolic Process;Cholesterol;Clinical;Dendritic Cells;Development;Energy Metabolism;Energy Metabolism Pathway;Enzymes;fatty acid oxidation;Future;Glucose;glucose metabolism;glucose transport;Glucose Transporter;Glycolysis;Goals;Human;Immune;immune checkpoint blockade;Immune response;immunogenicity;immunosenescence;Immunosuppression;Immunotherapy;Impairment;improved;in vivo;Infiltration;Investigation;Link;lipid metabolism;Lipids;Lymphocyte;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Metabolic;Metabolic Control;Metabolic Diseases;Metabolism;Molecular;Natural Immunity;neoplasm immunotherapy;novel;novel strategies;Outcome;Outcome Study;Patients;PD-1/PD-L1;PD-L1 blockade;Phenotype;programs;Proliferating;Public Health;Regulation;Regulatory T-Lymphocyte;Research;response;Role;senescence;Signal Transduction;Source;STAT1 gene;STAT3 gene;T-Cell Activation;T-Lymphocyte;Testing;TLR8 gene;transcription factor;tumor;Tumor Immunity;tumor microenvironment;Tumor Suppression;Tumor-Derived;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;Women's mortality;Writing

PROJECT_TITLE: Metabolic Control of Innate and Adaptive Immunity in Breast Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-Y(55)R]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety;Prostate Cancer;Urologic Diseases

ORG_CITY: NEW YORK

ORG_DEPT: UROLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE While traditional radical prostatectomy is the most popular treatment for clinically significant prostate cancer, significant risks are commonplace: urinary incontinence, erectile dysfunction, penile shortening, penile curvature/ deformation (Peyronie's disease), and inguinal hernia. In contrast, pelvic fascia-sparing radical prostatectomy, by preserving fascial support structures, penile arterial supply, and nerves, can reduce urinary incontinence by 80% and may improve patient survival. To overcome both the limitations of small, retrospective studies with limited cancer control follow-up outcomes and the typical barriers of low accrual and high costs of prospective trials, we propose a multi-center, randomized controlled trial with a novel, two-stage, informed consent process and a web portal for self-entry of patient-reported outcomes, which will strengthen the quality of evidence for this new surgical technique.

PI_NAMEs: ALLAF, MOHAMAD ;HU, JIM  (contact);KOWALCZYK, KEITH ;SCHAEFFER, EDWARD MATTHEW

PROGRAM_OFFICER_NAME: PERLOFF, MARJORIE

PROJECT_TERMS: abdominal wall;Adverse event;Affect;African American;American;Anatomy;Anterior;Anxiety;Area;Award;Bladder;Blood Vessels;Cancer Control;cancer surgery;Clinical Treatment;clinically significant;Complex;Consent;cost;Data;data portal;Deformity;Dorsal;Eligibility Determination;Erectile dysfunction;Evaluation;Event;Face;Fascia;Feedback;follow-up;Funding;Future;health related quality of life;improved;Incentives;Informed Consent;Inguinal Hernia;innovation;Location;Malignant neoplasm of prostate;Malignant Neoplasms;medical complication;men;Methodology;Morbidity - disease rate;neglect;Nerve;novel;novel strategies;operation;Operative Surgical Procedures;Outcome;Patient Outcomes Assessments;Patient Self-Report;Patients;Pelvis;penis;Peyronie Disease;Population;postoperative recovery;premature;preservation;primary outcome;Procedures;Process;prognostic;prospective;Prostate;Prostate-Specific Antigen;Publications;Publishing;quality assurance;Questionnaires;Radical Prostatectomy;Randomized;Randomized, Controlled Trials;Recurrence;Regrets;repaired;Reporting;Research;Research Personnel;Resected;response;Retrospective Studies;Risk;Robotics;self esteem;Series;Sex Functioning;Site;standard care;Structure;Surgeon;Surgical complication;Surgical margins;Surgical Oncology;Surveys;Techniques;Testing;Time;treatment arm;trial comparing;tumor;United States Preventative Services Task Force;urinary;Urinary Incontinence;web portal

PROJECT_TITLE: Pelvic fascia spARing radical prostatectomy TrIAL (PARTIAL)

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Sepsis

ORG_CITY: Juno Beach

ORG_NAME: AQUALUNG THERAPEUTICS CORP.

ORG_STATE: FL

PHR: NARRATIVE The COVID-19 pandemic, with associated unprecedented ARDS/VILI mortality rates, dramatically highlights the absence of FDA-approved ARDS/VILI pharmacotherapies. Aqualung Therapeutics has identified a novel ARDS/VILI target, eNAMPT, and have developed a highly effective monoclonal antibody, ALT-100 mAb, to directly addresses the serious unmet therapeutic need for novel ARDS/VILI therapies. Both ALT-100 mAb safety and efficacy will be assessed in the proposed R-44 PUERTA trial, a randomized Phase IIA clinical trial, as well as the development of an individualized therapeutic approach to reduce ARDS mortality.

PI_NAMEs: GARCIA, JOE G. N. (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Achievement;Acute Respiratory Distress Syndrome;Address;Award;Bacterial Pneumonia;Binding;Bioreactors;clinical research site;Clinical Trials;cohort;Continuous Positive Airway Pressure;COVID-19;COVID-19 pandemic;Cyclic GMP;cytokine;cytokine release syndrome;Death Rate;Development;Diagnosis;Dose;Double-Blind Method;Drug Kinetics;druggable target;efficacy evaluation;efficacy study;Excess Mortality;extracellular;Family suidae;FDA approved;first-in-human;Half-Life;healthy volunteer;humanized monoclonal antibodies;Hypoxemia;Incidence;Inflammation;Inflammatory;Investigation;Investigational Drugs;Ligation;Link;Lung;lung injury;Mechanical ventilation;Mechanical Ventilators;Molecular;Monoclonal Antibodies;mortality;Multiple Organ Failure;murine nodule inducing virus;New Drug Approvals;NF-kappa B;nicotinamide phosphoribosyltransferase;Nose;novel;Patients;Pattern;personalized therapeutic;Pharmacodynamics;Pharmacotherapy;Phase;Placebo Control;Placebos;Plasma;porcine model;Pre-Clinical Model;primary endpoint;Process;promoter;Proteins;Randomized;Rattus;Running;Safety;safety assessment;SARS-CoV-2 infection;secondary endpoint;Sepsis;Septic Shock;Severities;Severity of illness;Study Subject;systemic inflammatory response;Therapeutic;Therapeutic Intervention;therapeutic target;Tissues;TLR4 gene;Toxic effect;Trauma;Treatment Efficacy;ventilation;Ventilator;Ventilator-induced lung injury;Viral Pneumonia

PROJECT_TITLE: A Randomized Phase 2A Clinical Trial Pioneering the Utility of an eNAMPT-Reducing Therapy in ARDS/VILI: the PUERTA Trial


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Genetics;Nutrition;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: SURGERY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Pancreatic cancer cells rely on the RNA binding protein, HuR, to regulate a pro-survival response to low nutrient conditions in the tumor microenvironment. In this proposal, we show that antioxidant defense (via the IDH1 enzyme) and mitochondrial function are the principal effector arms of this adaptive program. Insights gained from this work should expose therapeutic opportunities to target deadly pancreatic cancer cells, and spare normal tissue.

PI_NAMEs: WINTER, JORDAN M (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: 3' Untranslated Regions;Acute;addiction;alpha ketoglutarate;alternative treatment;antioxidant enzyme;Antioxidants;arm;Binding;Binding Proteins;Binding Sites;Biological Assay;Biology;cancer cell;Cancer Etiology;Cell Culture Techniques;Cell Line;Cell Nucleus;Cell Survival;Cells;Cellular biology;Cessation of life;Chemistry;Chemoresistance;chemotherapy;Clinical Data;Clustered Regularly Interspaced Short Palindromic Repeats;Computational Biology;CRISPR/Cas technology;Culture Media;Cytoplasm;cytotoxic;Dependence;Diabetic mouse;drug testing;Elements;Engraftment;Enzymes;Exhibits;Fractionation;gemcitabine;Genes;Genetic;Glucose;Glutamine;Homeostasis;Hour;Hyperglycemia;Hyperglycemic Mice;Impairment;improved;in vivo;inhibitor;insight;Isocitrates;Knock-out;Knockout Mice;Lead;lead optimization;Maintenance;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediator;Medical;Messenger RNA;Metabolic;Metabolic stress;Metabolism;Mitochondria;Modeling;Molecular;Molecular Biology Techniques;mortality;mouse model;mRNA Expression;Mus;mutant;Mutation;NADP;new therapeutic target;Normal tissue morphology;novel;novel therapeutics;Nude Mice;Nutrient;overexpression;Oxidation-Reduction;Oxygen Consumption;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pathology;Performance;Pharmaceutical Chemistry;Pharmaceutical Preparations;posttranscriptional;Predisposition;programs;Property;protein expression;Proteins;Publishing;Reactive Oxygen Species;Refractory;Regulation;Research;Resistance;response;RNA Binding;RNA Interference;RNA Stability;RNA-Binding Proteins;Role;statistics;Streptozocin;Stress;Structure;Testing;Therapeutic;therapeutic target;Transcript;transcriptome;transcriptome sequencing;Transfection;Translations;tumor;tumor microenvironment;tumorigenesis;United States;Withdrawal;Work;Xenograft procedure

PROJECT_TITLE: Targeting pancreatic cancer's metabolic addiction to HuR


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

ORG_STATE: CA

PHR: The proposal aims to determine if non-invasive vagus nerve stimulation(nVNS) will alter: 1) the peripheral inflammatory biomarker profile, 2) the neural correlates of change in pain stimuli and 3) PTSD symptom severity and 4) life quality and function in Veterans with PTSD. The planned inflammatory biomarker and neuroimaging results can 1) promote knowledge of inflammatory and neurobiological mechanisms that contribute to pain in PTSD, and 2) advance our ability to provide targeted neuromodulation based interventions that support improved life quality and function for Veterans. These goals are consistent with the VA’s mission to sponsor research examining variables related to pathogenesis, diagnosis, and(ultimately) treatment of neuropsychiatric disorders.

PI_NAMEs: LERMAN, IMANUEL RUVIN (contact)

PROJECT_TERMS: active duty;Afghanistan;Aftercare;Amygdaloid structure;Anxiety;Autonomic nervous system;Aversive Stimulus;Biological Markers;Brain;Brain imaging;Brain region;Central Nervous System;Chronic;chronic pain;Clinical Practice Guideline;combat;combat veteran;comorbidity;cytokine;daily functioning;Data;Dermal;Development;Devices;Diagnosis;DSM-V;effective therapy;Effectiveness;FDA approved;follow-up;functional disability;Functional disorder;Functional impairment;functional improvement;Functional Magnetic Resonance Imaging;functional outcomes;Generations;Goals;Health;Heart Diseases;hypothalamic-pituitary-adrenal axis;immune activation;Immune System Diseases;improved;indexing;Inflammation;Inflammatory;Insula of Reil;Interleukin-1 beta;Interleukin-6;Intervention;Intervention Studies;Iraq;K-Series Research Career Programs;Knowledge;Longevity;Measures;Mental disorders;Methods;Mission;mortality;Nerve;neural;neural circuit;neural correlate;neurobiological mechanism;neuroimaging;neuromechanism;neuropsychiatric disorder;neuroregulation;nociceptive response;novel strategies;Outcome;Pain;pain processing;Participant;Pathogenesis;Pathologic;Perception;Peripheral;peripheral blood;Pharmacologic Substance;physical symptom;Physiological;Physiology;post-traumatic stress;Post-Traumatic Stress Disorders;Procedures;Productivity;Psychotherapy;Quality of life;Reporting;Research;response;Risk Factors;Scientist;service member;Services;Severities;Signal Transduction;Stimulus;symptomatic improvement;Symptoms;Technology;Time;TNF gene;tool;Training;Treatment Efficacy;treatment response;vagus nerve stimulation;Veterans;Vietnam;War;Work;World Health Organization Disability Assessment Schedule

PROJECT_TITLE: Vagal nerve stimulation to probe inflammation and brain in posttraumatic stress

STUDY_SECTION_NAME: Career Development Program - Panel I[RRD8]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Rare Diseases

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Influenza A-induced Acute Respiratory Distress Syndrome (IAV-induced ARDS) is associated with 45% mortality and current treatment is supportive. Glutamine metabolism plays a key role in immune function and viral replication but is understudied in IAV-induced ARDS. This project will target the glutamine pathway to identify key sites of metabolic regulation in alveolar macrophage effector function and viral replication, which will serve as the basis for my transition to become an independent investigator.

PI_NAMEs: SHAMAA, OBADA  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Acute Lung Injury;Acute Respiratory Distress Syndrome;aerobic glycolysis;Affect;alveolar bone;Alveolar Macrophages;Attenuated;Bioenergetics;Bone Marrow;Carbon;career;Cell Physiology;Cells;Cellular biology;Cellular Metabolic Process;Cessation of life;Chicago;Citric Acid Cycle;Consumption;cytokine;Data;Disease;Doctor of Philosophy;Education;Energy-Generating Resources;Enzyme Inhibitor Drugs;Enzymes;Excision;experimental study;Fellowship;Foundations;Future;Generations;Genetic Transcription;Genus Hippocampus;Glutamate Dehydrogenase;Glutaminase;Glutamine;Glycolysis;Goals;Grant;Hour;Immune;immune function;Immunology;improved;in vivo;Infection;Inflammatory;Inflammatory Response;Influenza;Influenza A virus;influenza infection;influenzavirus;insight;Interdisciplinary Study;knock-down;Knowledge;Label;Laboratories;liquid chromatography mass spectrometry;Lower respiratory tract structure;Lung;Lung Diseases;macromolecule;Macrophage;Mass Fragmentography;Measures;Mentors;Messenger RNA;Metabolic;Metabolism;metabolomics;Mitochondria;Molecular Biology;Monitor;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;new therapeutic target;Non-Essential Amino Acid;novel;Oxidation-Reduction;Pathogenesis;Pathway interactions;Physicians;Play;Population;Postdoctoral Fellow;Production;protein expression;Proteins;Proteomics;recruit;Regulation;Research;Research Personnel;Research Project Grants;Respiration;respiratory pathogen;Respiratory Tract Infections;response;Role;Scientist;Sepsis;Site;skills;Small Interfering RNA;Structure of parenchyma of lung;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Intervention;Tissues;Training;Universities;Viral Proteins;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Glutamine Metabolism in Alveolar Macrophages following Influenza A Infection


ADMINISTERING_IC: GM

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Infectious Diseases;Natural Products

ORG_CITY: CHAMPAIGN

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: The goal of this project is to enhance our understanding of the chemical diversity, biochemistry, biosynthesis and bioactivity of phosphonic and phosphinic acid natural products, an underexploited group of compounds with biomedical promise. The proposed studies are expected to discover novel natural products with medically rele- vant properties, lend insight into the unique biochemistry and bioactivity of this molecular group, and create research tools that allow efficient discovery and development of similar compounds.

PI_NAMEs: METCALF, WILLIAM W (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Address;Anabolism;Anti-Bacterial Agents;Anti-Hypertensive Agents;Anti-malarials;Antibiotics;Atlases;Bacteria;Bacterial Infections;bioactive natural products;Biochemical;Biochemistry;Bioinformatics;Biological;biosynthetic product;Carbon;Categories;cellular targeting;Chemicals;Classification;Clinical;clinical application;Collaborations;Collection;commercial application;Data;Development;Enterobacteriaceae;Enzymatic Biochemistry;Enzyme Inhibition;Enzymes;Erwinia;Escherichia coli;Family;Funding;fungus;Gene Cluster;Gene Modified;gene product;Genes;Genetic;Genome;Goals;Grouping;Growth;host-associated microbial communities;host-microbe interactions;improved;In Vitro;in vivo;inhibitor;inorganic phosphate;insight;Investigation;Knowledge;Medical;Medicine;member;Metabolic;Microbe;microbial;Mining;Molecular;Natural Products;novel;Osteoporosis;Output;Pathway interactions;Phosphinic Acids;phosphonate;Phosphonic Acids;Phosphorus;Production;programs;Property;Proteins;Publishing;Research;Research Project Grants;resistance gene;resistance mechanism;Riboflavin;Role;small molecule;Source;stem;Testing;tool;Universities;Virus Diseases

PROJECT_TITLE: Discovery, biosynthesis and bioactivity of phosphonic acid natural products

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Estrogen;Genetics;Precision Medicine;Women's Health Research

ORG_CITY: MILWAUKEE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative: The proposed research is relevant to public health because it focuses on the development of estrogen-based therapeutic strategies for people with advanced ER+ breast cancer. Once the mechanism of anti-cancer action and strategies to enhance efficacy of estrogen therapy have been determined, there is potential for significant improvement in the management of this disease. Thus, the proposed research is relevant to the mission of NCI through the development of enhanced treatments that would decrease morbidity and mortality in patients with breast cancer.

PI_NAMEs: MILLER, TODD W. (contact)

PROGRAM_OFFICER_NAME: DEY, SUMANA MUKHERJEE

PROJECT_TERMS: adjuvant endocrine therapy;advanced breast cancer;Affect;Anabolism;anti-cancer;Apoptosis;Aromatase Inhibitors;Breast Cancer Cell;Breast Cancer Patient;Breast Cancer Treatment;cancer cell;cancer recurrence;Cell Fate Control;Cell Line;Cells;Clinic;Clinical;clinical implementation;Clinical Trials;cytotoxic;cytotoxicity;Data;deprivation;Development;Disease Management;Disease Progression;DNA Damage;DNA Repair;effective therapy;Endocrine;Engineering;ERBB2 gene;ESR1 gene;Estradiol;Estrogen Antagonists;Estrogen Receptors;Estrogen Therapy;Estrogens;Fertilizers;Fulvestrant;Genes;Genetic Engineering;genetic profiling;Genetic Transcription;Goals;Growth;Heterozygote;homologous recombination deficiency;hormone therapy;improved;innovation;Investigation;Kinetics;Ligand Binding Domain;Malignant Breast Neoplasm;Mammary Neoplasms;Measurement;Measures;Mediating;Metastatic breast cancer;Mission;Modeling;Morbidity - disease rate;mortality;mutant;Mutation;Outcome;overexpression;patient derived xenograft model;patient subsets;Patients;Persons;pharmacologic;Poly(ADP-ribose) Polymerases;precision medicine;prevent;promoter;Public Health;Recurrent disease;Research;research clinical testing;Resistance;response;Role;Shapes;spatiotemporal;Tamoxifen;Testing;Therapeutic;therapy development;Time;Translating;Treatment Efficacy;treatment response;treatment strategy;tumor;tumor growth;women's diagnosis

PROJECT_TITLE: A precision medicine basis for estrogen therapy for advanced breast cancer

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Obstructive Pulmonary Disease;Clinical Research;Health Services;Lung;Patient Safety;Prevention

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Despite evidence that early treatment of chronic obstructive pulmonary disease (COPD) exacerbations improves outcomes, prior efforts to identify exacerbations prior to presentation to care have demonstrated mixed results. Because patients are instructed to increase their use of short-acting beta agonist (SABA) inhalers in response to worsening symptoms, electronic inhaler monitors that detect these increases may be used to identify exacerbations earlier in their course, expedite outpatient management, and decrease the risk for hospitalization. In this study, we will examine whether SABA inhaler use is associated with respiratory symptoms and exacerbations, examine possible risk factors for poor self-management, and conduct a qualitative study to explore participants’ thought processes surrounding their self-management.

PI_NAMEs: CASE, MEREDITH ANNE (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Acute;Address;Adrenal Cortex Hormones;Affect;Agonist;Ambulatory Care;Antibiotics;Bronchodilator Agents;career;Caring;CCL7 gene;Chronic Obstructive Pulmonary Disease;Classification;Clinical;cognitive function;cohort;cost;Data;Data Analyses;data exchange;depressive symptoms;Disease;Disease Progression;Early treatment;Electronics;Emergency department visit;Enrollment;Evaluation;experience;Guidelines;Health Care Costs;Health Services;Health Status;Healthcare Systems;Hospitalization;improved outcome;Incidence;Individual;Informal Social Control;Inhalators;Interview;Knowledge;Lead;Learning;Linear Regressions;Medical Care Team;medication compliance;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;mortality risk;Outpatients;Participant;patient subsets;Patients;prevent;Process;Qualitative Research;Recovery;remote patient monitoring;Research;Research Methodology;Research Personnel;Respiratory Signs and Symptoms;response;Risk;Risk Factors;Self Efficacy;Self Management;skills;Structure;Symptoms;Telephone;theories;Time;tool;Training;United States

PROJECT_TITLE: A Mixed Methods Evaluation of Developing COPD Exacerbations in the MARC Cohort

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Hematology;Immunotherapy;Orphan Drug;Precision Medicine;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Myelodysplastic syndrome (MDS) is a heterogeneous group of progressive diseases of blood-forming hematopoietic stem/progenitor cells. Mechanisms of progression are poorly understood, and treatment options are limited. Our proposed highly collaborative and synergistic studies will produce a vibrant understanding of the path from molecular mutations to functional consequences in MDS and create a library of resources that can be shared with the greater MDS scientific community to enable further progress toward improved treatment strategies.

PI_NAMEs: BLEAKLEY, MARIE  (contact);DOULATOV, SERGEI

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Affect;Antigen Targeting;Antigens;Apoptosis;Architecture;Biological;Biological Assay;Biology;biomarker identification;Catalogs;Categories;Cell Culture Techniques;Cell Line;Cell model;Cell Reprogramming;Cells;Cellular immunotherapy;Characteristics;Clinical;Clinical Data;Clonal Evolution;Clonal Expansion;Clonal Hematopoietic Stem Cell;cohort;Communities;Coupled;Custom;cytopenia;Data;Development;Disease;disease model;DNA Repair;DNA Sequence Alteration;driver mutation;Drug Combinations;Drug resistance;drug sensitivity;drug testing;Dysmyelopoietic Syndromes;Engraftment;epigenetic regulation;Epitopes;gene discovery;Gene Expression;Gene Expression Profile;Genes;genetic signature;Genetic Transcription;genome integrity;Genomics;genotyped patients;Germ Lines;Goals;Hematological Disease;Hematopoiesis;hematopoietic differentiation;Hematopoietic stem cells;Heterogeneity;high throughput screening;Human;immunodeficiency;Immunotherapy;Impairment;improved;In Vitro;in vivo;Individual;induced pluripotent stem cell;Ineffective Hematopoiesis;inhibitor;innovation;interdisciplinary approach;Investigation;Investigational Drugs;leukemia;Libraries;Link;Machine Learning;machine learning algorithm;Marrow;Measures;Methodology;Modeling;Molecular;Molecular Profiling;Multiomic Data;Mus;Mutation;novel;online repository;overexpression;Pathogenesis;Pathway interactions;patient population;Patient-Focused Outcomes;Patients;permissiveness;Pharmaceutical Preparations;Pharmacotherapy;Population;Population Heterogeneity;Prediction of Response to Therapy;predictive marker;premalignant;progenitor;programs;Progressive Disease;Proteins;Proteome;Proteomics;rational design;Recommendation;Recording of previous events;Recurrence;repository;Research;Research Personnel;Resources;response;restoration;Risk;RNA Splicing;Sampling;screening;single-cell RNA sequencing;Somatic Mutation;Specific qualifier value;stem cell model;stem cells;Subgroup;Survival Analysis;sustainable resource;T cell therapy;T-Cell Receptor;T-Cell Receptor Therapy;T-Lymphocyte;targeted treatment;Technical Expertise;Testing;Text;therapeutic development;therapy resistant;transcription factor;transcriptome;Transplantation;treatment strategy;Validation;Xenograft Model

PROJECT_TITLE: Development of Innovative Resources to Advance MDS Research


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE In this MIRA research program we will investigate how chemical properties of drug compounds affect drug absorption through skin that has been treated with microneedles, and we will study this in the laboratory, in animals, and in patients of different ages. This knowledge will help us identify time and cost-effective methods for developing microneedle products that could be used for a broad range of medical conditions.

PI_NAMEs: BROGDEN, NICOLE K (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: absorption;Affect;Age;age related;Age Years;Animals;Area;Biological;Cavia;Characteristics;Charge;chemical property;clinical application;clinically relevant;cohort;cost effective;Development;Dosage Forms;Dose;Drug Compounding;Drug Delivery Systems;Drug Kinetics;Enrollment;Environment;Formulation;Goals;Health;Human;human subject;hydrophilicity;Hydrophobicity;improved;In Vitro;in vivo;innovation;ionization;Kinetics;Knowledge;Laboratories;Length;Medical;Methods;micropore;Mission;National Institute of General Medical Sciences;Needles;Oral;Pathway interactions;Patients;Permeability;Pharmaceutical Preparations;Pharmacologic Substance;Plasma;programs;Property;Research;Route;Skin;small molecule;Structure;Testing;Time;Transdermal substance administration;translational approach;Work

PROJECT_TITLE: A translational approach to predicting small molecule drug permeation through microneedle-treated skin

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative ACLY is a key metabolic and epigenetic mediator whose dysregulation has been implicated in diseases such as cancer. The full-length protein is preferentially expressed in tumors over another major splice isoform, but ACLY isoforms have not been closely studied. The goal of my project is to understand the structural, molecular, and biological impacts of ACLY alternative splicing, which will provide insight into the tumor-supporting roles of ACLY and potentially lead to new therapeutic strategies.

PI_NAMEs: SUPPLEE, JULIANNA  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Acetyl Coenzyme A;Agar;Alternative Splicing;ATP Citrate (pro-S)-Lyase;Biochemical;Biogenesis;Biological;Biological Assay;Cancer cell line;cancer type;Carcinogens;Cell Fractionation;Cell model;Cells;Cholesterol;Citrates;Code;Coenzyme A;Colorectal Cancer;comparative;Complex;Crosslinker;Cryoelectron Microscopy;Data;data mining;detection of nutrient;Disease;Epigenetic Process;epigenetic regulation;Event;Exons;experimental study;Fatty Acids;Fluorescence Microscopy;Fractionation;Gene Expression;genetic regulatory protein;Glucose;Goals;Histone Acetylation;In Vitro;insight;Isotopes;Knockout Mice;Laboratories;Length;Ligation;lipid biosynthesis;lipid metabolism;liver cancer model;Location;Lysine;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Mediator;Membrane Proteins;Messenger RNA;Metabolic;Metabolic Diseases;metabolomics;mimetics;Molecular;mouse model;Mus;mutant;Mutate;Normal tissue morphology;novel therapeutic intervention;Nuclear;Nutrient;Oxaloacetates;Pathway interactions;Phenotype;Phosphorylation;Phosphotransferases;Play;Primary carcinoma of the liver cells;Property;Protein Acetylation;Protein Isoforms;protein protein interaction;Proteins;Proteomics;Reaction;Recombinant Proteins;Regulation;RNA Splicing;Role;Serine;Source;Structure;Testing;The Cancer Genome Atlas;Therapeutic;Tissues;Translating;Translations;tumor;Tumor Cell Line;tumor growth;tumor metabolism;Tumor Promotion;Variant;Western Blotting;Wild Type Mouse

PROJECT_TITLE: Molecular and cancer-related roles of ACLY exon 14


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Networking and Information Technology R&D (NITRD);Neurosciences;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Magnetic resonance spectroscopy (MRS) can provide metabolic information noninvasively for assessment of tumor type and treatment response in any body part. The clinical impact of MRS has been limited by the technical expertise required to make these measurements. This research project will develop and evaluate automated tools to make MRS measurements easier and more robust for both research and clinical uses.

PI_NAMEs: MARJANSKA, MALGORZATA  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: 19q;3-Dimensional;Adoption;Adult;Anatomy;arm;automated analysis;Automation;Back;Body part;Body System;Brain;Brain Neoplasms;Calibration;cancer therapy;Choline;Chromosomal Loss;Clinical;clinical practice;Clinical Research;clinical research site;Communities;Computer software;convolutional neural network;Cystathionine;Data;data acquisition;Data Analyses;drug discovery;Exhibits;Glioma;image guided;imaging modality;improved;in vivo;individualized medicine;interest;Isocitrate Dehydrogenase;Judgment;Lesion;Magnetic Resonance Imaging;magnetic resonance spectroscopic imaging;Magnetic Resonance Spectroscopy;Malignant neoplasm of brain;Malignant Neoplasms;Manuals;Measurement;Measures;Metabolic;Methods;Molecular;Monitor;Morbidity - disease rate;Morphologic artifacts;mortality;Multi-Institutional Clinical Trial;Mutate;Mutation;Normal tissue morphology;Observational Study;open source;open source tool;Pathologic;Patient Care;Patients;Performance;Phenotype;Phospholipid Metabolism;Physiologic pulse;Positioning Attribute;prevent;Procedures;programs;prospective;Protocols documentation;Reporting;Reproducibility;Research;Research Project Grants;Scanning;Site;skills;Source;Spatial Distribution;spectroscopic data;Spectrum Analysis;System;Technical Expertise;Techniques;Testing;Time;tool;Training;translational barrier;transmission process;Treatment outcome;treatment response;tumor;tumor progression;Tumor Subtype;Vendor;Water;Work

PROJECT_TITLE: Full-stack automation for reliable and reproducible MRS of brain cancer

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE It is well-documented that where you reside in America shapes when you die, and this has been shown to be particularly true among low-income Americans where longevity varies substantially in different places of the country. This proposal studies Medicaid enrollees that migrate to understand whether “place-based inequalities” are driven by the causal impact of places on access to evidence-based behavioral healthcare treatment, and to identify the characteristics of places associated with improved access, health, and health equity.

PI_NAMEs: WALLACE, JACOB WITT SAMUEL (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Address;Adoption;Adult;alcohol-related death;American;Area;behavioral health;California;Caring;Characteristics;Climate;Clinical;Communities;Complex;Consensus;Country;County;Data Set;design;Destinations;Disparity;Economics;Effectiveness;Ethnic Origin;evidence base;Evidence based treatment;Family;Gender;geographic difference;Geography;Goals;Grant;Health;health care availability;health care delivery;health care disparity;health care service;health care service utilization;health difference;health disparity;health disparity populations;health equity;health inequalities;Health Insurance;Health Services;Health Services Accessibility;Healthcare;Improve Access;improved;Individual;Inequality;Inequity;innovation;Institution;Insurance Coverage;Interdisciplinary Health Team;Intervention;Life Expectancy;Literature;Living Costs;Longevity;Low income;Low Income Population;Medicaid;Medicare;men;Mental disorders;Mental Health Services;Methodology;middle age;migration;mortality;National Institute of Mental Health;Neighborhoods;novel;Outcome;Persons;Pharmaceutical Preparations;Policies;policy implication;Population;population health;Positioning Attribute;programs;Public Health;Public Policy;Quasi-experiment;Race;Research;Research Design;Research Personnel;Role;Shapes;Social Gradients;sociodemographic group;sociodemographics;Sorting;Source;Substance Use Disorder;Suicide;System;Time;United States;United States National Institutes of Health;Vermont;Woman

PROJECT_TITLE: Access to Healthcare as a Driver of Place-Based Inequality in Mid-Life Mortality: Evidence from Movers in Medicaid


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative The FDA has issued a call for research that provides ”Evaluations of the impact and possible unintended consequences of tobacco regulatory actions among specific populations, as appropriate, addressing how such actions may increase or decrease tobacco-related health disparities.” Our proposed study will examine the impact of the anticipated flavor ban policy using a health equity lens. We will provide the FDA CTP with evidence of the impact of the ban on the intended (i.e., smoking reduction and increased cessation) and unintended (e.g., increased smoking rates) behavioral consequences on African-American/Black and Hispanic/Latino young adults.

PI_NAMEs: STERLING, KYMBERLE L (contact)

PROGRAM_OFFICER_NAME: KIMMEL, HEATHER L

PROJECT_TERMS: Address;Advertisements;Advertising;African American;African American population;American;Behavior;Behavioral;Behavioral Model;Belief;Benefits and Risks;Black Populations;Black race;Characteristics;Cigar;cigarillos;Communication;Communities;Complement;Data;Data Collection;Development;Discrimination;Disease;Disparity;experience;Exposure to;Focus Groups;Future;Health;health disparity;health equity;Hemp;Hispanic;Hispanic Populations;hookah;Impact evaluation;Industry;innovation;interest;Label;Latino;Latino Population;Malignant Neoplasms;Marketing;Measures;Misinformation;Modeling;Perception;Persuasive Communication;Police;Policies;Politics;polytobacco use;Population;Predisposition;preference;prospective;Qualitative Research;Research;Research Methodology;Respondent;response;risk perception;Sampling;Smoker;Smoking;Smoking Behavior;Source;Surveys;Testing;Tobacco;tobacco flavor;Tobacco Industry;tobacco products;tobacco regulatory science;Tobacco use;young adult

PROJECT_TITLE: The C'RILLOS Project: Impact of Tobacco Regulatory Policy on Dynamic Use of Exclusive, Dual or Poly Cigar and Other Tobacco Product Use among Young Adults


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer;Rural Health;Social Determinants of Health

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Among current T32 training programs for cancer prevention, control, and survivorship, few focus on health equity among rural populations and none focus on cancer in the rural, Appalachian population. Addressing Rural cancer Inequities through Scientific Excellence (ARISE) is a postdoctoral training program at the University of Kentucky that will be a collaboration among the Center for Health Equity Transformation (CHET), the NCI-designated Markey Cancer Center (MCC), Center for Clinical and Translational Science (CCTS), UK Center for Appalachian Research in Environmental Sciences (UK-CARES), six colleges and 10 departments to provide interdisciplinary training in behavioral cancer research focused on rural disparities. The training program will have three tracks, environment, risk behavior, and health care delivery and will provide didactic, research experience and mentoring.

PI_NAMEs: DIGNAN, MARK B (contact);SCHOENBERG, NANCY E.

PROGRAM_OFFICER_NAME: LIM, SUSAN E

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Cancer;Clinical Research;Cost Effectiveness Research;Precision Medicine;Urologic Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Project Narrative The project seeks to validate a more reliable and accurate non-invasive assay to be used to detect bladder cancer and predict response to therapy and which, over the long-term, could have a profound impact on care of bladder cancer patients leading to improved care and reduced healthcare costs.

PI_NAMEs: ROSSER, CHARLES J (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Adjuvant;Adjuvant Therapy;Age;Algorithms;BCG Live;Biological Assay;Biological Markers;Bladder;Blood;cancer biomarkers;Cancer Detection;cancer diagnosis;Cancer Patient;Caring;Clinic;Clinical;clinically relevant;cohort;Cohort Studies;Cost Analysis;cost effective;cost effectiveness;Cost Savings;Cost utility;Costs and Benefits;Cystectomy;Cystoscopy;Cytology;Data;detection assay;detection method;Diagnosis;diagnostic assay;diagnostic signature;Disease;Effectiveness;Ensure;Evaluation;Excision;Funding;Gender;General Population;Guidelines;Health Care Costs;Hematuria;high risk;Image;Immunoassay;improved;Institution;intravesical;Invasive Lesion;Laboratories;Life;Malignant neoplasm of urinary bladder;Manuscripts;markov model;Measures;Medicine;Methodology;Microscopic;Molecular Profiling;multiplex assay;Muscle;muscle invasive bladder cancer;Newly Diagnosed;Parents;Patient Care;patient response;patient stratification;Patients;Performance;predicting response;Prediction of Response to Therapy;predictive modeling;Predictive Value;preservation;prospective;Prospective cohort;protein biomarkers;Publishing;Recommendation;Recording of previous events;Recurrence;Research;Residual Neoplasm;response;Retrospective cohort;Risk;risk stratification;Sampling;Schedule;Specificity;Survival Rate;Technology;Technology Transfer;Testing;Time;Tobacco;Translating;Translations;Transurethral Resection;treatment response;tumor;Tumor stage;tumorigenesis;urinary;Urine;Validation;Weight

PROJECT_TITLE: MULTIPLEXED PROTEIN BIOMARKER-BASED ASSAY FOR THE DETECTION OF BLADDER CANCER


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Lung;Rare Diseases

ORG_CITY: Chicago

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: PROJECT NARRATIVE Oropharyngeal head and neck cancers have escalated to epidemic levels in the United States, and survivors are suffering from life-long, devastating swallowing disorders with limited therapeutic options. This clinical trial investigates a novel swallowing treatment that trains initiation of swallowing during the expiratory phase of respiration to improve swallowing safety and efficiency. Consistent with the National Cancer Institute's research mission, this study may discover a new therapy option, that could be combined with traditional therapies, to improve swallowing recovery for survivors of oropharyngeal head and neck cancer.

PI_NAMEs: MARTIN-HARRIS, BONNIE J (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Adverse effects;Aerodigestive Tract;Aftercare;Ambulatory Monitoring;arm;aspirate;Barium swallow;Biomechanics;Bolus Infusion;Breathing;Cancer Survivor;cancer therapy;chemotherapy;clinical translation;Clinical Trials;Complex;Controlled Clinical Trials;curative treatments;Custom;Deglutition;Deglutition Disorders;drinking;Eating;Environment;Epidemic;expiration;Fibrosis;Food;Frequencies;functional gain;Goals;Head and Neck Cancer;health training;Hour;Human Papillomavirus;Impairment;improved;Individual;Ingestion;innovation;Intervention;Invaded;Larynx;Learning;Limb structure;Liquid substance;Measures;Mission;Monitor;Movement;National Cancer Institute;novel;novel therapeutics;Operative Surgical Procedures;Oropharyngeal;Outcome;Participant;Patients;Pattern;Penetration;Pharyngeal structure;Phase;Physiological;Physiology;Positioning Attribute;Posture;primary endpoint;Radiation;Randomized;Recovery;recruit;remote therapy;Research Institute;Respiration;respiratory;response;Safety;secondary endpoint;sensor;Severities;Sexually Transmitted Diseases;Signal Transduction;smartphone application;Survival Rate;Survivors;telehealth;Testing;Therapeutic;Time;Tissues;Tongue;Toxic effect;Traction;traditional therapy;Training;Treatment-related toxicity;United States;visual feedback;vocal cord;Wakefulness;wearable sensor technology;Work

PROJECT_TITLE: Training Swallowing Initiation during Expiration: Impact on Safety and Efficiency Following Treatment for Oropharyngeal Head and Neck Cancer

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Digestive Diseases;Patient Safety

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: Establishing the optimal anesthetic approach for inguinal hernia repair could improve post-surgical outcomes for adults aged 65 years and older. This project will culminate in a well-designed pilot study of local anesthesia versus general anesthesia for inguinal hernia repair in older adults. The pilot will facilitate a multisite randomized trial and accelerate the applicant's career trajectory toward becoming an independently funded surgical researcher with a focus on aging.

PI_NAMEs: BALENTINE, COURTNEY J (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Acceleration;Admission activity;Adult;Age;Aging;Agreement;American;American College of Surgeons;Anesthesia procedures;Anesthetics;arm;career;caregiver quality of life;Caregivers;Caring;clinical trial analysis;Clinical Trials;Cognitive;cognitive function;Cohort Studies;comorbidity;cost;Country;Data;Databases;design;Eligibility Determination;Enrollment;Exposure to;functional status;Funding;General Anesthesia;Geriatrics;Goals;Health system;Hernia;Hospital Administrators;Hospitals;human old age (65+);Impaired cognition;implementation science;improved;improved outcome;Individual;Inguinal Hernia;Institution;instrument;Interview;Knowledge;Local anesthesia;Measures;member;Morbidity - disease rate;multi-site trial;Nurses;older adult;older patient;operation;Operative Surgical Procedures;Outcome;Outcome Assessment;Outcome Measure;Outcome Study;Participant;Patient-Focused Outcomes;Patients;Physical Function;Physicians;Pilot Projects;pilot trial;Population;Positioning Attribute;Postoperative Complications;postoperative recovery;Procedures;professor;prospective;Provider;Quality of life;Randomized;randomized trial;Recovery;recruit;repaired;Research Personnel;Resources;Site;Societies;Structure;Surgeon;surgical research;System;Target Populations;Techniques;Testing;Time;Training;trial comparing;United States Department of Veterans Affairs

PROJECT_TITLE: A Pilot Study of Local Anesthesia for Inguinal Hernia Surgery in Older Adults


ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: How a gene is expressed differentially depending on the context such as cell type and environment is a fundamental question in biomedicine with substantial implications in human diseases. However, the mechanism is poorly understood because of the shortcomings of the current technology, which involves mainly fixed, thus non-physiological, cells and tissues. Our proposed research will develop versatile intravital technology for interrogating transcriptional dynamics in living mammals, combining intravital multiphoton microscopy and molecular/genomic engineering.

PI_NAMEs: LIM, HYUNGSIK  (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Address;Adult;Animals;Biological Assay;Biological Sciences;Brain;Breathing;cell fixing;cell type;Cells;cellular imaging;cognitive task;Complex;Development;differential expression;Disease;Engineering;Enhancers;Environment;Foundations;Gene Expression;Genes;Genetic Transcription;genome annotation;Genomics;human disease;Image;in vivo;interest;Knowledge;Laboratories;Learning;Mammals;Messenger RNA;Methods;Molecular;multiphoton microscopy;Mus;Neurodegenerative Disorders;Neurons;Organism;Pathogenicity;Physiology;Play;Property;Regulation;Regulatory Element;Research;Role;sensor;single molecule;Structure;success;Technology;Time;Tissues;Transcript;transcription regulatory network;Visualization

PROJECT_TITLE: Imaging cell-type-specific transcription in living mammalian brain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: UW STAR PROGRAM – PROJECT NARRATIVE The expressed purpose of the UW STAR Program is to provide students from underrepresented populations (i.e., African American, Latino/Hispanic, Native American/Alaska Native, and Native Hawaiian/Pacific Islander); first generation college students, economically and educationally disadvantaged students and students with disabilities with short-term, intensive summer research experiences that will strongly encourage and support matriculation into graduate and professional educational pathways (i.e., MD, MD/PhD, PhD, and MS degree tracks) in NHLBI-focused cardiovascular, pulmonary, and hematologic research.

PI_NAMEs: PORTMAN, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Academic skills;Address;African American;Alaska Native;Behavioral;Behavioral Sciences;biobehavior;Blood;Cardiovascular system;college;Communities;disabled students;disadvantaged student;Doctor of Philosophy;economic disparity;Education;education pathway;Educational process of instructing;educationally disadvantaged;Evaluation;experience;Faculty;Feedback;First Generation College Students;Funding;Generations;Geography;Goals;Graduate Education;Grant;Health;health disparity;Health Professional;Heart;Hematology;Hispanic;innovation;Institution;laboratory experience;Laboratory Research;Latino;Learning Skill;lectures;Lung;matriculation;Medical Students;Mentors;National Heart, Lung, and Blood Institute;Native Americans;Native Hawaiian or Other Pacific Islander;Participant;participant enrollment;Pathway interactions;Population;Professional Education;programs;recruit;Research;Research Methodology;Research Personnel;Role;Students;success;summer research;Technical Expertise;Techniques;Training;Training Programs;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;Underrepresented Students;Universities;Washington

PROJECT_TITLE: University of Washington Stipends for Training Aspiring Researchers (STAR) Program


NIH_SPENDING_CATS: Bioengineering;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: BLACKSBURG

ORG_DEPT: BIOLOGY

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative Spatiotemporal and mechanical processes are prevalent and critical for the cell, but remain poorly understood. The PI’s laboratory will use mathematical modeling to synthesize experimental data and elucidate the roles of spatiotemporal and mechanical processes, as well as their coupling with biochemical pathways, in cellular functions. Focusing on mitosis and bacterial motility, this research will create fundamental knowledge about the underlying cellular mechanisms, which will promote future innovations in cancer therapy and bacterial control.

PI_NAMEs: CHEN, JING  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Address;antimicrobial;Area;Bayesian Analysis;Biochemical;Biochemical Pathway;Biological;cancer therapy;Cell model;Cell Physiology;Cells;Cellular biology;Centrosome;Chemistry;Chromosome Segregation;Chromosomes;Clostridium perfringens;Complex;Coupling;Data;driving force;experience;experimental study;Feedback;Functional disorder;Future;Health;heterogenous data;Individual;innovation;Knowledge;Laboratories;Laws;Malignant Neoplasms;mathematical model;Mechanics;Methodology;Methods;Microbial Biofilms;microbial community;Mitosis;Mitotic spindle;Modeling;Molecular;Motility;Myxococcus xanthus;novel;Physics;Process;Regulatory Pathway;Research;Role;Signal Transduction;spatiotemporal;Technology;Therapeutic Agents;tool

PROJECT_TITLE: Mathematical modeling of spatiotemporal and mechanical processes in cellular functions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dietary Supplements;Emergency Care;Health Services;Hematology;Orphan Drug;Pain Research;Pediatric;Rare Diseases;Sickle Cell Disease

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Pain is the hallmark of sickle cell disease (SCD), and is the leading cause of hospitalizations, emergency room visits, missed school, and is associated with an increased death rate. We found that patients with SCD and pain had low levels of the amino acid arginine in their blood, and we also demonstrated that arginine supplementation during acute pain events signi?cantly reduced the amount of narcotics needed to treat sickle cell pain in children and dramatically improved pain scores at discharge compared to placebo. We propose to investigate the bene?ts and safety of arginine for the treatment of patients with SCD and pain in a phase 3 randomized, placebo-controlled clinical trial where neither the patient nor the clinical team know which therapy the patient is receiving, since Arginine is a promising new therapy that could change the way we treat acute pain in SCD.

PI_NAMEs: MORRIS, CLAUDIA R (contact)

PROGRAM_OFFICER_NAME: DI FRONZO, NANCY L

PROJECT_TERMS: Absence of pain sensation;Accident and Emergency department;Acute;acute care;acute chest syndrome;Acute Pain;Affect;African American population;Amino Acids;Applied Research;Area;arginase;Arginine;arginine treatment;biobank;Biological Availability;Blood;Blood Cells;Blood specimen;Blood Transfusion;Blood Vessels;Cell Adhesion Molecules;Cell Density;Cells;Child;Child Care;Childhood;Clinical;clinical practice;clinically relevant;Complex;Data;Death Rate;Deterioration;dietary supplements;Disease;Dose;double-blind placebo controlled trial;Down-Regulation;Drug Delivery Systems;Drug Kinetics;efficacious intervention;efficacy evaluation;Electrons;Emergency Care;Emergency department visit;Erythrocytes;Event;experience;Future;Hemolysis;Hemolytic Anemia;Hepatic;Hospitalization;Hospitals;Hour;Hydration status;improved;Individual;Inflammatory;Infrastructure;Inherited;Inpatients;Intervention;Intravenous;Kidney;Length of Stay;lung injury;metabolome;Mitochondria;mitochondrial dysfunction;Monitor;morphine equivalent;mortality;mouse model;Narcotics;neglect;new therapeutic target;Nitric Oxide;novel therapeutics;off-patent;Opioid;opioid sparing;opioid use;oxidation;Oxygen;Pain;pain outcome;pain score;Pathway interactions;Patient Admission;Patient Care;Patient Outcomes Assessments;Patients;pediatric emergency;Perfusion;Phase;phase III trial;Physiology;Placebos;Plasma;Platelet Aggregation Inhibition;pleiotropism;primary endpoint;product development;Randomized;randomized placebo-controlled clinical trial;Reperfusion Injury;Research;Resolution;Safety;Schools;secondary outcome;Sickle Cell;Sickle Cell Anemia;sickling;standard of care;Supplementation;Syndrome;Time;Time Study;Transgenic Mice;trend;Vasodilator Agents;Veno-Occlusive Disease;Visit;ward

PROJECT_TITLE: 1/2 Sickel Cell Disease Treatment with Arginine Therapy (STArT Trial)


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Data Science;Immunization;Infectious Diseases;Machine Learning and Artificial Intelligence;Prevention;Social Determinants of Health;Vaccine Related

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Three of the most pressing scientific challenges in vaccine-preventable disease research are (1) estimating time-varying disease transmissibility (i.e., the effective reproduction number, REff); (2) real-time monitoring and measurement of transmissibility-relevant behaviors (e.g., vaccine hesitancy, mobility, etc.); and (3) epidemic forecasting as a function of said behaviors. To address these challenges across relevant vaccine-preventable diseases, we propose the development of (1) a meta-analytical tool to generate ensemble estimates for REff; (2) a surveillance system for monitoring vaccine hesitancy and an inference system for improved measurements of human mobility; and (3) a generalizable agent-based model that integrates behavioral parameters informed by the aforementioned surveillance and inference systems to produce more accurate disease forecasts. By addressing these challenges through a combination of digital data streams and machine learning, we hope to enable data-driven decision-making for clinicians and public health policymakers alike.

PI_NAMEs: MAJUMDER, MAIMUNA SHAHNAZ (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Address;analytical tool;Behavior;Behavioral;Collaborations;Communicable Diseases;community building;COVID-19 pandemic;Data;data streams;Decision Making;Development;digital data;Disease;Disease Outbreaks;Epidemic;Epidemiology;Growth;Health behavior;Human;improved;Individual;Institution;Machine Learning;Measles;Measurement;Measures;Modeling;Monitor;Natural Language Processing;Nature;news;Policy Maker;Public Health;real time model;real time monitoring;recruit;Reproduction;Research;Research Personnel;social media;System;Time;United States;vaccine hesitancy;Vaccines;virtual laboratory

PROJECT_TITLE: Digital data streams and machine learning for real-time modeling of vaccine-preventable infectious diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)R]


ORG_CITY: VALLEY CENTER

ORG_NAME: INDIAN HEALTH COUNCIL, INC.

PHR: Program Narrative Indian Health Council, Inc. (IHC) with San Diego State University (SDSU) and University of California San Diego (UCSD), intends to build upon their already existing long-term research partnership with the following proposed projects/studies in the NARCH X application: Student Development Program and the Administrative Core. These projects will further expand and refine strategies to recruit students from local academic institutions into biomedical and behavioral sciences as well as, continue to provide strong mentorship and guidance for the students in and outside of the region and by providing administrative and fiscal oversight, coordinating communication and dissemination of information to foster the academic and community partnerships, supporting the CA-NARCH SDP in establishing a trained cohort of AI/AN scientists dedicated to impacting the health disparities of AI/AN populations, and by guidance in and conducting relevant evaluation to ensure the success of the core and CA-NARCH SDP.

PI_NAMEs: CALAC, DANIEL J. (contact)

PROGRAM_OFFICER_NAME: RICHARDS, CRYSTAL LYNETTE

PROJECT_TERMS: Academic achievement;Address;Alaska Native;Alaska Native population;American Indian Population;American Indians;Area;Assistantship;Awareness;Bachelor's Degree;Behavioral Sciences;California;cohort;Communication;Communities;community based research;community college;community engagement;community organizations;community partnership;Competence;Country;County;Dedications;Degree Completion;Development;Development Plans;Doctor of Philosophy;Doctor's Degree;Drops;Educational process of instructing;Educational workshop;Ensure;Ethics;Evaluation;Event;experience;Faculty;faculty mentor;Fostering;Foundations;Funding;Funding Opportunities;graduate school;Health;health disparity;health equity;health training;higher education;Human Resources;improved;Indigenous;Individual;Information Dissemination;Infrastructure;Institution;Institutional Review Boards;interest;Knowledge;Language;Leadership;Learning;Master of Science;matriculation;Measures;member;Mentors;Mentorship;Methods;Minority Groups;multidisciplinary;Native American Research Center for Health;Native Americans;Occupations;Outcome;Positioning Attribute;Program Development;Program Evaluation;programs;Recording of previous events;recruit;Research;Research Ethics;Research Methodology;Research Personnel;Research Project Grants;research study;Resources;Science;Science Enrichment;Scientist;Self Efficacy;Series;skill acquisition;skills;Source;STEM program;student participation;Student recruitment;Students;success;Training;tribal leader;tribal member;Tribes;Trust;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: NARCH 11- Student Development Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-Y(55)]


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PHR: Program Narrative The CA NARCH XI Administrative Core will help fulfill the major aims and goals of all Center components by pursuing the following specific aims: 1) To provide leadership and management, including administrative and fiscal oversight of the CA-NARCH student development project; 2) To coordinate communication and dissemination of information between the local tribes, tribal leaders, and the student development program team; 3) To support the cultural interface and augment research ethical training in the SDP with biannual workshops led by the Tirbal IRB chair and members; 4) To seek out and disperse information on funding opportunities through NARCH and other sources for continued development of training and mentoring programs and/or research projects; 5) To evaluate progress of the CA-NARCH in achieving its objectives and milestones. The specific aims will support the efforts of the CA-NARCH mission of conducting highly relevant, American Indian/Alaskan Native (AI/AN) community-based research and establishing a trained cohort of AI/AN scientists dedicated to impacting the health disparities of AI/AN populations.

PROJECT_TERMS: Address;Alaska Native;American Indian Population;American Indians;Area;California;career;Clinic;cohort;Communication;Communities;community based participatory research;community based research;community college;community partnership;Core Grant;County;Dedications;Development;Education;Educational workshop;Ensure;Ethics;Evaluation;experience;Face;Fostering;Funding;Funding Opportunities;Goals;Health;health disparity;Health Sciences;Human Subject Research;Indigenous;Information Dissemination;Institution;Institutional Review Boards;Leadership;member;Mentors;Methods;Mission;Modeling;Native American Research Center for Health;Native-Born;Play;Population;Program Development;programs;Recording of previous events;recruit;Research;Research Assistant;Research Ethics;Research Methodology;Research Project Grants;Role;Running;Scientist;Service provision;social culture;Source;Structure;Students;success;Training;tribal leader;tribal Nation;Tribes;Universities;Work

PROJECT_TITLE: NARCH 11 Administrative CORE

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-Y]


ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Overall Program Narrative Brain tumors are the most common pediatric solid malignancies, and the leading cause of cancer-related death in children. This program will continue to advance understanding of the mechanisms driving diffuse intrinsic pontine glioma and multiple subtypes of medulloblastoma. The Program also investigates therapeutic vulnerabilities for these childhood brain tumors that inflict significant morbidity and mortality.

PI_NAMEs: BAKER, SUZANNE J. (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: ACVR1 gene;Address;antibody test;Antibody-drug conjugates;Automobile Driving;Basic Science;biological adaptation to stress;Biological Models;Biometry;Blood - brain barrier anatomy;Brain;Brain Neoplasms;Cancer Etiology;cancer predisposition;Cell Lineage;Cell membrane;Cells;Child;Childhood;Childhood Brain Neoplasm;childhood cancer mortality;Childhood Glioma;Clinical Trials;Collaborations;Competence;Complex;Data;data integration;Development;Developmental Process;Diffuse intrinsic pontine glioma;Disease;Drug Combinations;drug testing;Epigenetic Process;epigenome;experience;Experimental Designs;experimental study;FDA approved;FRAP1 gene;Functional dependence;Functional disorder;Funding;Genes;Germ Lines;Goals;Growth;H3 K27M mutation;Heterogeneity;hindbrain;human disease;Immunotherapy;improved;inhibitor;insight;loss of function;Maintenance;Malignant - descriptor;Malignant Childhood Neoplasm;Malignant Neoplasms;Maps;Medulloblastoma;member;Methyltransferase;Molecular;Morbidity - disease rate;mortality;mTOR inhibition;Mutate;Mutation;Neoplasms;neuropathology;next generation sequence data;novel;novel therapeutics;oligodendrocyte lineage;Paper;Pathogenesis;Pathway interactions;patient derived xenograft model;Pediatric Neoplasm;Pharmaceutical Preparations;Phenotype;PIK3CG gene;Play;Preclinical Testing;Predisposition;Productivity;programs;Proteome;Publishing;Regulation;Research Personnel;Resources;response;Role;Seminal;Series;SHH gene;SMYD3 gene;Solid;Source;spatiotemporal;Study models;success;Susceptibility Gene;Techniques;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;therapeutic target;Transcriptional Regulation;transcriptome;Translating;translational impact;Translational Regulation;Translations;treatment response;tumor;tumor initiation;Tumor Subtype;tumorigenesis;Variant;Work

PROJECT_TITLE: NORMAL & NEOPLASTIC GROWTH IN THE BRAIN


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: HAMPTON

ORG_NAME: HAMPTON UNIVERSITY

PHR: Project Narrative This is a partnership between Hampton University (HU) and the Tisch Cancer Institute (TCI) at Mount Sinai School of Medicine that seeks to establish robust collaborations through on-site and online training and education to increase HU research capacity in the area of genetics and genomics and health disparities, using the examples of prostate and breast cancer. The final goal is to create a competitive and sustainable joint Center for Genetics and Genomics Cancer Research, encompassing the genetics and genomics aspects of health disparities to explain population differences in breast and prostate cancer occurrence and outcome.

PI_NAMEs: AZAD, NEELAM ;HEYLIGER, SIMONE OLIVIA (contact)

PROGRAM_OFFICER_NAME: RODRIGUEZ, LARITZA MARIA

PROJECT_TERMS: Address;African American population;anti-cancer research;Area;Behavioral;Biological;Biometry;cancer epidemiology;cancer genetics;cancer genomics;cancer health disparity;cancer type;Clinical Investigator;Collaborations;Consultations;Coupled;Data;Data Collection;Detection;didactic education;Disparity;education research;Educational Activities;Educational Materials;Educational process of instructing;Ensure;Environment;Environmental Risk Factor;Epidemiology;epidemiology study;Etiology;experience;Exposure to;Extramural Activities;Faculty;faculty research;Feasibility Studies;Funding;Genetic;genetic epidemiology;Genetic Variation;genomic epidemiology;Genomics;Goals;hands on research;Health;Health Disparities Research;health disparity;improved;innovation;Institution;Interdisciplinary Study;Joints;Lead;Learning;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;medical schools;Mentors;Methodology;Methods;Minority;model building;novel;Outcome;Pilot Projects;Population;Productivity;programs;proton therapy;Records;Registries;Research;Research Institute;Research Personnel;Research Project Grants;Resources;Scientist;Series;Site;social factors;statistics;Students;success;survivorship;Time;Training;Training Activity;Training and Education;Translational Research;Travel;treatment and outcome;treatment response;undergraduate education;Universities;Vulnerable Populations

PROJECT_TITLE: 2/2: Feasibility study to build a collaboration in genetics and genomic cancer research


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PHR: Project 1 Narrative Diffuse intrinsic pontine gliomas (DIPG) are incurable brainstem tumors arising almost exclusively in children. This project will determine how disrupted glial development contributes to DIPG tumorigenesis, why particular mutations are selectively associated with brainstem or midline gliomas, and what molecular features modulate tumor response to inhibitors of pathways mutated in DIPG.

PROJECT_TERMS: 3-Dimensional;Acceleration;ACVR1 gene;Address;age related;Anaplastic astrocytoma;Automobile Driving;Bioinformatics;Biometry;Brain;Brain Stem;Brain Stem Glioma;Brain Stem Neoplasms;Cell Line;Cell Lineage;cell type;Cells;Child;Childhood Brain Neoplasm;Childhood Brain Stem Neoplasm;Childhood Glioma;Complex;CRISPR/Cas technology;Data;Dependence;design;Development;Diffuse intrinsic pontine glioma;Embryo;Embryonic Induction;Epigenetic Process;Etiology;Event;experimental study;FRAP1 gene;Gene Expression Profile;Genes;Genetically Engineered Mouse;glial cell development;Glioma;glioma cell line;Gliomagenesis;Goals;Growth;H3 K27M mutation;Heterogeneity;hindbrain;Histone H3;improved;in vivo;Incidence;Induced Mutation;inhibitor;insight;Invaded;Investigation;knock-down;Knock-in Mouse;Lesion;Link;Location;loss of function;loss of function mutation;Maintenance;Mediating;Medulloblastoma;Methylation;Modeling;Molecular;Molecular Profiling;Morbidity - disease rate;mortality;mouse model;Mutate;Mutation;Neonatal;Neoplasms;neuropathology;novel;oligodendrocyte lineage;oligodendrocyte progenitor;Oncogenic;Organ;Pathogenesis;Pathway Analysis;Pathway interactions;patient derived xenograft model;Patients;Pattern;Phenotype;Physiological;PIK3CA gene;PIK3CG gene;Polycomb;precision medicine;preference;promoter;Recurrence;Regulation;Research;response;Role;Signal Transduction;Solvents;Source;spatiotemporal;stem cells;Structure;Supratentorial;Therapeutic;therapeutic target;Three-Dimensional Imaging;TP53 gene;transcriptome;treatment response;tumor;tumor growth;tumor initiation;tumorigenesis;Xenograft procedure

PROJECT_TITLE: Molecular Pathogenesis of Pediatric High-Grade Glioma


PHR: PROJECT NARRATIVE:  The CA-NARCH Student Development Program will recruit AI/AN students in STEM fields from 3 regional four  year universities and a community college and will follow them through their successive academic programs,  from community college through doctoral level graduate programs. The purpose of the CA-NARCH SDP is to  increase the number of independent AI/AN culturally competent researchers who are committed to addressing  highly relevant public health issues within Native communities. CA-NARCH students will gain critical research  experience, will receive training in western and indigenous research methods, and will have high interface with  local AI communities to increase community engagement and trust in research.

PI_NAMEs: ARMENTA, RICHARD FRANK (contact)

PROJECT_TERMS: Academic achievement;academic program;Address;Alaska Native;American Indians;Area;Assistantship;Associate Degree;Awareness;Bachelor's Degree;Behavioral Sciences;California;CCL7 gene;cohort;Collaborations;Communication;Communities;community based research;community college;community engagement;community organizations;Competence;Country;County;cultural competence;Dedications;Degree Completion;Development;Development Plans;Doctor of Philosophy;Doctor's Degree;Drops;Educational process of instructing;Educational workshop;Elements;Ethics;Event;experience;Faculty;faculty mentor;Funding;graduate school;Grant;Health;health disparity;health equity;Health Professional;Health Sciences;higher education;Human Resources;improved;Indigenous;Individual;Infrastructure;interest;Knowledge;Language;Learning;Master of Science;matriculation;Measures;member;Mentors;Mentorship;Methods;Minority Groups;Native American Research Center for Health;Native Americans;Occupations;Outcome;Positioning Attribute;Postbaccalaureate;Program Development;Program Evaluation;programs;Public Health;Qualifying;Recording of previous events;recruit;Research;Research Ethics;Research Methodology;Research Personnel;Reservations;Resources;Science;Science Enrichment;Scientist;Self Efficacy;Series;Services;skill acquisition;skills;Social support;STEM field;STEM program;student participation;Student recruitment;Students;success;symposium;synergism;Thinking;Time;Training;Training and Education;Tribal Council;tribal member;tribal organization;Tribes;Trust;Underrepresented Students;United States National Institutes of Health;Universities;virtual environment;Work

PROJECT_TITLE: Student Development Program


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Circadian misalignment and synaptic dysfunction are common to several neurodevelopment, neuropsychiatric and neurodegenerative syndromes, but the mechanisms that directly link the circadian system to synaptic function are poorly understood. We have recently discovered a novel role for the phosphorylation of BMAL1 – a component of the core circadian clock mechanism – in regulating a circadian rhythm of synaptic vesicles, a key computational unit for information transfer. The proposed research will determine how BMAL1 regulates circadian presynaptic plasticity through biochemical interactions and/or biophysical organization of synaptic proteins and will identify what pre-synaptic signals modulate it, with the goal of uncovering targets the can modulate synaptic vesicle dynamics.

PI_NAMEs: GILETTE, NICOLE MARIE (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Acute;Alzheimer's Disease;Amino Acid Sequence;Animals;ARNTL gene;autism spectrum disorder;Behavior;behavioral plasticity;Biochemical;Biological Assay;Biophysical Process;Biophysics;brain cell;Calcium;Calmodulin;calmodulin-dependent protein kinase II;Cells;circadian;Circadian desynchrony;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Clock protein;Co-Immunoprecipitations;Cognition;controlled release;Cues;Darkness;Data;Disease;druggable target;Elements;Exhibits;experimental study;Feedback;feeding;Forskolin;Functional disorder;Gene Expression;genetic approach;Genetic Transcription;Goals;Hour;Impairment;In Vitro;in vitro Assay;in vivo;insight;Investigation;Knowledge;Learning;life span;Light;Link;Liquid substance;Mammals;Mediating;Mediator;Memory;Molecular;mouse model;Mus;Nerve Degeneration;Nervous System;Nervous System Disorder;neurodevelopment;Neurologic;Neuromodulator;neuronal cell body;Neurons;neuropsychiatry;neuroregulation;Neurotransmitters;Norepinephrine;novel;Organism;Periodicity;pharmacologic;Phase;Phosphorylation;Phosphotransferases;Physical condensation;presynaptic;Process;Property;Proteins;Recombinant Proteins;reconstitution;recruit;Recycling;Regulation;Research;response;Role;Schizophrenia;segregation;Series;Serotonin;serotonin receptor;Signal Pathway;Signal Transduction;Sleep;sleep regulation;spatiotemporal;Structure;success;Synapses;Synapsins;synaptic function;Synaptic plasticity;Synaptic Vesicles;Syndrome;System;Testing;Therapeutic;Time;transcription factor;Translations;Variant;Work

PROJECT_TITLE: Biochemical and Biophysical Tuning of Presynaptic Function by the Clock Protein BMAL1


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Spinal cord injury leads to long-lasting impairment, and currently, there is no cure for paralysis. Although electrical spinal cord stimulation has shown promising results in recovering lost movements, the mechanisms of action are not properly understood. This project uses novel, non-invasive techniques to determine how different structures in the central nervous system respond to spinal cord stimulation and training.

PI_NAMEs: SEANEZ, ISMAEL  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acceleration;Area;auditory stimulus;Award;Behavior;body-machine interface;career development;Central Nervous System;Chronic;Clinical;Clinical Research;Computers;Cortical Cord;Corticospinal Tracts;Cross-Over Studies;Data;Development;Evaluation;Event;evidence base;Exercise;exercise training;experience;functional improvement;Funding;Goals;Grant;Human;Impairment;improved;Individual;Injury;joint mobilization;Joints;Knowledge;Lead;Leg;Life;Mediating;Mentors;Methods;Motor;motor control;Motor Evoked Potentials;motor function improvement;motor impairment;Movement;multidisciplinary;Musculoskeletal Equilibrium;neural;neural circuit;neurological rehabilitation;neuromechanism;Neuronal Plasticity;neurophysiology;neuroregulation;Neurostimulation procedures of spinal cord tissue;novel;open label;Outcome;Paralysed;Participant;Patients;personalized medicine;Persons;Phase;physical therapist;programs;Randomized, Controlled Trials;Reaction Time;Recovery;Recovery of Function;rehabilitation strategy;Rehabilitation therapy;Reporting;Research;Research Design;Research Personnel;Residual state;response;reticulospinal tract;Rodent Model;Sensory;skills;Spinal;Spinal Cord;Spinal cord injury;Spinal Cord Plasticity;strength training;Structure;success;Synapses;Techniques;Testing;Time;Training;Transcranial magnetic stimulation;Translating;Translational Research;Walking;Work;Writing

PROJECT_TITLE: Neural plasticity by spinal cord stimulation and training in people with spinal cord injury


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence

ORG_CITY: CORVALLIS

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE:  RNA is fundamental for all life, and is involved in complex interactions that impact human health and disease; however integrative analyses are often performed at the genomic level rather than the transcriptome level. We propose two complementary approaches to uncover new biological insights about RNA sequence and structure, and their impact on efficiency of translation from RNA transcript into protein, and how this process is regulated. We also propose to create a user-friendly, web-accessible infrastructure for the investigation and visualization of RNA sequence, structure, and interactions, by integrating publicly-available data, along with the data that we generate through our proposed work, which will allow us and other researchers to make new discoveries about RNA function, with implications for the critically important development of RNA-based vaccines and interpreting disease-associated synonymous variants within transcripts.

PI_NAMEs: HENDRIX, DAVID ANTHONY (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Algorithms;Attention;Awareness;Binding;Binding Proteins;Biological;Biological Assay;Biotechnology;Cataloging;Catalogs;cell type;Code;Codon Nucleotides;Complex;crosslinking and immunoprecipitation sequencing;Custom;Data;Data Analyses;Data Set;Databases;Development;Disease;Elements;Evaluation;Family;Foundations;Genes;genetic variant;Genome;Genomics;Health;Higher Order Chromatin Structure;Human;Human Cell Line;Human Development;improved;In Vitro;Infrastructure;Initiator Codon;insight;intermolecular interaction;Investigation;Life;Location;Machine Learning;machine learning method;machine learning prediction;Maps;Measures;Medical;Methods;MicroRNAs;Modeling;mRNA Stability;mRNA Translation;Neurophysiology - biologic function;novel;Outcome;Output;Pathogenesis;Pattern;Peptide Initiation Factors;Positioning Attribute;Process;protein crosslink;Proteins;Regulation;Research;Research Personnel;Resources;Ribosomal RNA;ribosome profiling;Ribosomes;RNA;RNA Binding;RNA Sequences;RNA Splicing;RNA vaccine;RNA-Binding Proteins;Role;Site;Standardization;Structure;Structure-Activity Relationship;Techniques;TIE gene;Training;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Transfection;translational model;Translational Regulation;Translations;Update;user-friendly;Variant;Visualization;web-accessible;Work

PROJECT_TITLE: Integrative transcriptomics to uncover functional elements and disease-associated variants in RNA

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Physical Rehabilitation;Post-Traumatic Stress Disorder (PTSD);Rehabilitation;Violence Research

ORG_CITY: NEW YORK

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE 27 million people worldwide are estimated to suffer chronic somatic pain as a result of systematic torture, which is likely undetected by evaluators due to confounding psychiatric illness and a lack of diagnostic tools. This gap in the detection of pain results in exclusive psychological treatment rather than multimodal therapies, substantially limiting rehabilitation, placing vulnerable individuals at higher risk of drug abuse, and increasing healthcare expenditures. The objectives of this study are to improve the diagnosis of pain in torture survivors (SA 1), to qualitatively characterize acceptability of somatic pain treatment (SA 2), and to assess the feasibility of recruiting and retaining subjects in a subsequent clinical trial (SA 3).

PI_NAMEs: KAUR, GUNISHA  (contact)

PROGRAM_OFFICER_NAME: SYPEK, ELIZABETH IRENE

PROJECT_TERMS: Anesthesia procedures;Behavioral Model;blind;Brachial Plexus Neuropathies;Brief Pain Inventory;career;career development;Chronic;chronic pain;chronic pain management;Clinical;Clinical Ethics;Clinical Research;Clinical Trials;Combined Modality Therapy;Complex;Confidence Intervals;Data;design;Detection;Development Plans;Diagnosis;diagnostic tool;disability;Drug abuse;Enrollment;Environment;Evaluation;evidence base;experience;Face;Feedback;Future;Goals;Guidelines;health care service utilization;Health Expenditures;Health Status;high risk;Human Rights;improved;Injections;Instruction;Intervention;Interview;Investigation;K-Series Research Career Programs;Leg Injuries;Lumbosacral plexus structure;Major Depressive Disorder;Medical;Medicine;Mental disorders;Mentorship;Methods;Modeling;Neurosciences Research;non-opioid analgesic;novel;Outcome;Pain;Pain management;Pain Measurement;Pain Research;pain sensitivity;Pathology;Patients;Persons;Physical therapy;Physicians;Population;Post-Traumatic Stress Disorders;pressure;primary outcome;prospective;Protocols documentation;Provider;psychologic;Recommendation;recruit;Refugees;Rehabilitation therapy;Research;Research Project Grants;Sample Size;Sampling;Scientist;skills;socioeconomics;Specialist;Survivors;Suspensions;targeted treatment;Testing;Time;Torture;Training;Trauma;treatment guidelines;Treatment outcome;trigger point;United Nations;Upper Extremity;Vulnerable Populations

PROJECT_TITLE: Chronic Pain Diagnosis and Treatment in Torture Survivors

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

ORG_CITY: BALTIMORE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Our NEI Core Grant for Vision Research (P30) research plan is designed to support and facilitate the success and productivity of the many and diverse vision research programs at The Wilmer Eye Institute and throughout Johns Hopkins, and also to encourage collaborative, innovative, and multi- disciplinary research studies.

PI_NAMEs: MUMM, JEFFREY  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Animal Model;Bioinformatics;Biometry;Blindness;Clinical Trials;Core Grant;design;Drug Delivery Systems;Epidemiology;Eye;Eye Development;Eye diseases;Funding;Future;Genetic study;Image;Infrastructure;innovation;Interdisciplinary Study;International;Microscopy;Monitor;Nanotechnology;Pathogenesis;Productivity;programs;Research;Research Activity;Research Project Grants;research study;Research Support;Resources;Scientist;Services;Structure;success;Technology;Training;Training Activity;translational study;Universities;Update;Vision;Vision research;Visual disability

PROJECT_TITLE: P30 Wilmer Core Grant for Vision Research


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome

PHR: Project Narrative: Training and Education Program Diverse investigators play an integral role in identifying novel research questions, perspectives, and solutions to complex biomedical challenges. Yet, diversifying the biomedical research workforce remains a major challenge in the US, despite the fact that underrepresented minorities make up the most rapidly growing segment of the US population Thus, in a unique partnership between the Icahn School of Medicine at Mount Sinai and Hampton University, we propose to provide hybrid training and education to increase the research capacity, engagement, and success of the HU scientific workforce, with particular emphasis on genetics and genomics and cancer disparities research.

PI_NAMEs: HEYLIGER, SIMONE OLIVIA (contact)

PROJECT_TERMS: Acceleration;Advisory Committees;anti-cancer research;Applications Grants;Area;Biomedical Research;Biometry;cancer genetics;cancer genomics;cancer health disparity;Clinical;Clinical Research;Collaborations;Communication;community engaged research;Complex;Coupled;Data Science;design;Development;Distance Learning;Education;Educational Curriculum;Electronic Mail;Epidemiology;equity, diversity, and inclusion;Faculty;faculty community;Feasibility Studies;Fostering;Funding;Genetic;genome sciences;Genomics;Goals;Grant;Health Disparities Research;health disparity;Human Resources;Hybrids;Impact evaluation;innovation;insight;Institution;Intervention;lectures;medical schools;meetings;member;Mentorship;Minority;Minority Groups;minority investigator;Monitor;novel;Online Systems;people of color;Persons;Play;Population;Productivity;programs;Progress Reports;Publications;Research;Research Methodology;Research Personnel;Research Project Grants;Research Support;Research Training;response;Role;Schedule;Series;Site;skills;Students;success;symposium;System;Teacher Professional Development;Training;Training and Education;translational cancer research;translational genomics;Underrepresented Minority;United States National Institutes of Health;Universities;Update;Videoconferencing;virtual;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Pasadena

ORG_NAME: DOHENY EYE INSTITUTE

ORG_STATE: CA

PHR: Project Narrative This U01 grant application is submitted in response to RFA EY-21-002 “Age-related Macular Degeneration (AMD) Integrative Biology Initiative”, with the goal of determining if patient-derived induced pluripotent stem cell (iPSC)-retinal pigment epithelium (RPE) can be used to discover the underlying pathophysiology of AMD. Our studies will focus on two single nucleotide polymorphisms (SNPs) with the highest odds ratio for developing advanced AMD- Age-Related Maculopathy Susceptibility 2/High Temperature Requirement A1 (ARMS2/HTRA1) and Complement Factor H (CFH) . Our hypothesis is that each genetic risk SNP has a unique molecular signature, determined from changes in the proteome and metabolome. Results from our studies will provide novel insight into the specific biological pathways and how they are affected by these high-risk SNPs.

PI_NAMEs: FERRINGTON, DEBORAH ANN (contact)

PROGRAM_OFFICER_NAME: COOK, TIFFANY

PROJECT_TERMS: Affect;Aftercare;age effect;Age related macular degeneration;Applications Grants;Bioinformatics;Biological;biological adaptation to stress;Biological Assay;Biological Models;Biological Process;Biology;Cell Line;Cells;Clinical;Clinical Research;Complement Factor H;Coupled;Defect;Elderly;Exhibits;Exposure to;Foundations;Functional disorder;Genes;Genetic;Genetic Risk;Genotype;geographic atrophy;Goals;Growth Factor;high risk;High temperature of physical object;improved;induced pluripotent stem cell;insight;Investigation;Knowledge;Laboratories;macula;Metabolism;metabolome;Mitochondria;Molecular;Molecular Profiling;neovascularization;New York;novel;Odds Ratio;Oxidative Stress;Parents;Pathogenesis;Pathologic;Pathway interactions;Patient Care;patient derived induced pluripotent stem cells;patient population;Patient-Focused Outcomes;Patients;personalized medicine;Physiological;Population;Predisposition;Proteins;Proteome;Protocols documentation;prototype;response;Risk;risk variant;Single Nucleotide Polymorphism;stem cells;Stress;Structure of retinal pigment epithelium;targeted treatment;Testing;therapy design;therapy development;Thick;Treatment Factor;Vascular Endothelial Growth Factors

PROJECT_TITLE: Deciphering the mechanisms associated with high-risk AMD genotypes for ARMS2/HTRA1 andComplement Factor H


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PHR: Project Narrative Medulloblastoma is the most common malignant brain tumor in children. Of the four subgroups, Group3 is the most aggressive and patients invariably experience recurrence with metastases and die of their disease. A better undertstanding of the genes and molecular mechanims that drive Group 3 tumorigenesis may lead to the identification of novel targets for therapeutic intervention to improve survival.

PI_NAMEs: ROUSSEL (SHERR), MARTINE F. (contact)

PROJECT_TERMS: Acceleration;Address;Affect;Age;Allografting;ATAC-seq;Automobile Driving;Binding Proteins;blood-brain barrier crossing;Brain;Brain Neoplasms;Cell Line;Cell model;chemotherapy;Child;ChIP-seq;Chromatin;Chromatin Remodeling Factor;Chromatin Structure;Classification;Cleavage Under Targets and Release Using Nuclease;Clinical Trials;combinatorial;Complex;Data;Dependence;Development;Disease;Dropout;Enzymes;Epigenetic Process;epigenetic regulation;expectation;experience;EZH2 gene;FDA approved;functional loss;Funding;Future;gain of function;Gene Expression;Genes;genome-wide;Goals;Grant;hindbrain;histone methyltransferase;Histones;Human;Immunoprecipitation;improved;In Vitro;in vivo;Incidence;inhibitor;Knockout Mice;Libraries;loss of function;Luciferases;Lysine;Maintenance;Malignant - descriptor;Malignant Childhood Neoplasm;Malignant neoplasm of brain;Mass Spectrum Analysis;Medulloblastoma;Methylation;Methyltransferase;Modification;Molecular;mouse model;Mus;Mutation;Neoplasm Metastasis;Neoplasms;new therapeutic target;novel;novel therapeutics;Nuclear;Oncogenes;Operative Surgical Procedures;overexpression;Pathway interactions;Patients;Pattern;Pediatric Neoplasm;Pharmaceutical Preparations;pharmacologic;Post-Translational Protein Processing;Prognosis;programs;Proliferating;Proteins;Proteome;Proteomics;Radiation;Recurrence;Repressor Proteins;Role;Shapes;SHH gene;small hairpin RNA;SMYD3 gene;Subgroup;success;Systems Biology;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;transcriptome;transcriptomics;Transgenic Mice;treatment effect;tumor;Tumor Suppressor Proteins;tumorigenesis;Work;Xenograft procedure

PROJECT_TITLE: Role of Methyltransferases in MYC-driven Medulloblastoma


NIH_SPENDING_CATS: Immunization;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Vaccine Related

ORG_CITY: Auburn

ORG_NAME: AUBURN UNIVERSITY AT AUBURN

ORG_STATE: AL

PHR: PROJECT NARRATIVE Infectious diseases continue to be a major threat to the health and safety of people around the world, and technologies that can rapidly produce vaccines with long shelf-life, such as that promised by peptide-based vaccines, would significantly improve society’s ability to meet global needs in the face of a novel pathogen. Our ability to rapidly develop peptide-based vaccines is dependent on the identification of epitopes, or pathogen fragments, that will sufficiently train the immune system to recognize a novel pathogen as foreign. The proposed work is aimed at developing computational tools that account for the genetic variability between pathogen strains and across individuals to efficiently identify epitopes for the development of peptide-based vaccines.

PI_NAMEs: KIESLICH, CHRIS A. (contact)

PROJECT_TERMS: Accounting;Affect;Animal Model;antigen processing;Antigens;Area;Base Sequence;Binding;combat;Communicable Diseases;computerized tools;Computing Methodologies;Coupled;Data;Data Set;Development;emerging pathogen;Epitopes;Generations;Genetic;genetic information;Health;Human;Hypersensitivity;Immune;Immune response;Immune system;Immunology;improved;Individual;interest;Life;Logic;Machine Learning;machine learning model;Malignant Neoplasms;Measures;Modeling;Molecular Machines;molecular modeling;Mutation;Outcome;outcome prediction;pathogen;peptide based vaccine;Peptides;personalized cancer vaccines;personalized medicine;Persons;Predictive Value;Prevalence;Process;Proteins;Receptor Cell;Research;Safety;Sampling;Societies;Statistical Data Interpretation;Statistical Models;T-Cell Receptor;T-Lymphocyte Epitopes;Technology;Training;Uncertainty;Vaccine Design;Vaccine Production;Virus;Work

PROJECT_TITLE: Development of computational tools for accounting for host variability in predicting T-cell epitopes