NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Rare Diseases

PHR: NARRATIVE: ADMINISTRATIVE CORE (CORE A) The Administrative Core provides the support and infrastructure for research, financial oversight, and regulatory monitoring. It achieves its goals by promoting clear and open communications among all SPORE investigators, Core leaders, Career Enhancement Program and Developmental Research Program awardees, External and Internal Advisory Board members, and patient advocates. Ultimately, it seeks to optimize the successful outcome of the translational research of this SPORE in order to improve the lives of patients with brain cancer.

PI_NAMEs: LANG, FREDERICK F (contact)

PROJECT_TERMS: Administrative Coordination;Administrator;Advocate;Affect;Animals;anti-cancer research;Basic Science;biobank;Bioinformatics;Biometry;Brain Neoplasms;Cancer Center;Cancer Center Support Grant;career;Clinical Trials;Collaborations;Communication;Consult;Consultations;data quality;Development;Discipline;Doctor of Philosophy;Electronic Mail;Ensure;Evaluation;Event;Goals;improved;Institution;interdisciplinary approach;Lead;Leadership;lectures;Malignant neoplasm of brain;meetings;member;Minority;Monitor;multidisciplinary;National Cancer Institute;Organ;Outcome;Pathology;Patients;Policies;Preparation;programs;Progress Reports;Publications;quality assurance;Quality Control;recruit;Regulation;Reporting;Research;Research Infrastructure;Research Personnel;Resources;Schedule;Site;Structure;success;symposium;timeline;Translational Research;Woman;Work

PROJECT_TITLE: Administrative Core (Core A)


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: NARRATIVE: PROJECT 1 In a recent paradigm shift, oncolytic adenoviruses are recognized as new type of cancer immunotherapy, suggesting that oncolytic viruses may have powerful synergistic effects when combined with other immunotherapeutic strategies. In this project, we explore in pre-clinical models the biological effects of combining our novel oncolytic adenovirus, Delta-24-RGD, with home-grown genetically engineered, immunosuppression- resistant natural killer cells (called eCB-NK-TR-/GC- cells). We test in two sequential Phase 1 window-of- opportunity clinical trials the safety, efficacy and biological effects of eCB-NK-TR-/GC- cells alone and in combination with Delta-24-RGD in patients with recurrent glioblastoma.

PI_NAMEs: FUEYO, JUAN  (contact)

PROJECT_TERMS: Adoptive Cell Transfers;Adrenal Cortex Hormones;Adult;Aftercare;Animal Model;anti-cancer;anti-PD1 antibodies;anticancer activity;arm;Biological;Biological Models;Biological Response Modifier Therapy;Bypass;cancer cell;cancer immunotherapy;cancer type;Cell Therapy;Cells;Child;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Combined Modality Therapy;cytokine;Data;Diffuse intrinsic pontine glioma;Dose;engineered NK cell;Engineering;Enrollment;expectation;experimental study;Funding;Genes;Genetic Engineering;Germ Lines;Glioblastoma;Glioma;Glucocorticoid Receptor;Goals;Hepatitis Delta Virus;Home;Iatrogenesis;Immune;Immune response;Immunologic Stimulation;Immunosuppression;Immunotherapeutic agent;immunotherapeutic virotherapy;Immunotherapy;Injections;Innate Immune System;Knowledge;Laboratories;Major Histocompatibility Complex;Malignant Glioma;Malignant neoplasm of brain;Memory;Modeling;mouse model;Multicenter Trials;Mus;Natural Killer Cells;Natural Resistance;NK cell therapy;novel;novel therapeutics;NR3C1 gene;oncolysis;oncolytic adenovirus;Oncolytic viruses;Patient-Focused Outcomes;Patients;pembrolizumab;Phase;Phase I Clinical Trials;Positioning Attribute;pre-clinical;Pre-Clinical Model;preclinical study;programs;receptor;Recommendation;recruit;Recurrence;Resistance;Safety;Sampling;Shapes;Specimen;standard care;success;synergism;Testing;Therapeutic;Toxic effect;Transforming Growth Factor beta;Translating;tumor;tumor microenvironment;tumor-immune system interactions;Umbilical Cord Blood;Viral;Virotherapy;Virus;Work

PROJECT_TITLE: Project 1: Combine Viro-Immunotherapy and Natural Killer Cells for the Treatment of Gliomas

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RPRB-8 (J1)]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Immunotherapy;Neurosciences;Rare Diseases

PHR: NARRATIVE: PROJECT 2 Immunotherapy is a powerful anti-cancer strategy, but it has not benefited patients with glioblastoma (GBM) largely due to immunosuppressive GBM-associated microglia/macrophages (GAMs), characterized by dysfunctional phagocytosis. We discovered that GAM-mediated immunosuppression is driven by downregulation of a novel complex, called QKI-PPARβ-RXRα (QPR), which regulates phagocytosis. In this project we overcome the immunosuppression of GBMs by restoring GAM phagocytosis using brain-penetrant, small molecule activators of QPR, bexarotene and KD3010, which we evaluate for the first time in preclinical studies and ultimately test bexarotene in a phase I clinical trial with a window-of-opportunity component in patients with GBM.

PI_NAMEs: HU, JIAN  (contact)

PROJECT_TERMS: adaptive immune response;Adaptive Immune System;Aftercare;Agonist;Animal Model;anti-cancer;Antigen Presentation;Automobile Driving;Bexarotene;Binding Proteins;Biological;Biological Assay;Brain;Cell Physiology;Cells;Cellular Membrane;Characteristics;Clinical Trials;Complex;conditional knockout;Cutaneous T-cell lymphoma;cytokine;Cytotoxic T-Lymphocytes;Developmental Therapeutics Program;Disease;DNA;Dose;Down-Regulation;effector T cell;Exhibits;Failure;Family;fatty acid biosynthesis;FDA approved;Genes;Glioblastoma;Glioma;Gliomagenesis;Goals;Growth;Human;Immune;immune cell infiltrate;immune checkpoint blockade;Immunomodulators;Immunosuppression;Immunotherapeutic agent;Immunotherapy;Impairment;In Vitro;in vivo;Innate Immune System;Knowledge;Macrophage;Malignant neoplasm of brain;Mediating;Membrane;Membrane Fluidity;Membrane Lipids;Microglia;Molecular;mouse model;Mus;Mutate;Myelogenous;Natural Immunity;neoplastic cell;Neuroglia;novel;Oral;Patients;Penetration;Peroxisome Proliferator-Activated Receptors;Phagocytes;Phagocytosis;Pharmaceutical Preparations;Phase I Clinical Trials;polarized cell;Population;pre-clinical;Pre-Clinical Model;preclinical study;Process;programs;Proteins;Recurrence;restoration;RNA;RXR;RXRA gene;Safety;Sampling;Signal Transduction;single-cell RNA sequencing;small molecule;Specimen;T-Cell Activation;Testing;Therapeutic;Time;Tissue Sample;tumor;Tumor Antigens;tumor growth;tumor microenvironment;tumor progression;tumor-immune system interactions;tumorigenic;Unsaturated Fatty Acids

PROJECT_TITLE: Project 2: Restore Myeloid Phagocytosis in Glioblastoma by Targeting the QKI/PPARb/RXRa Complex


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Immunotherapy;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PHR: NARRATIVE: PROJECT 3 Current survival for patients with Shh-α medulloblastoma with TP53 mutation is near zero, and although patients with Shh-δ, can have a better outcome, they experience terrible morbidity from craniospinal radiation and near- certain mortality after recurrence. We have identified in these Shh MBs a unique point mutation in a non-coding small nuclear RNA called U1, which results in aberrant splicing of transcripts and consequent post-transcriptional hypermutation with thousands of unique epitopes being expressed in the cancer cells. This project leverages this mutation by undertaking a clinical trial using checkpoint inhibitors and by developing CAR T cells against the most immunogenic epitopes, giving hope to the many young people with this devastating disease.

PI_NAMEs: TAYLOR, MICHAEL D. (contact)

PROJECT_TERMS: Adolescent;Adopted;Adult;aggressive therapy;Biopsy;Brain Neoplasms;cancer cell;Cells;Cellular biology;checkpoint therapy;Child;Childhood Malignant Brain Tumor;chimeric antigen receptor T cells;Clinical;clinical translation;Clinical Trials;Collaborations;Collection;Combined Modality Therapy;design;Development;Disease;Epitopes;Event;Exhibits;experience;experimental study;Future;Generations;Genomic DNA;Genomics;Goals;human tissue;Immune;Immune checkpoint inhibitor;immunodeficiency;immunogenic;Immunotherapy;improved outcome;Induced Mutation;Infant;Institution;International;Introns;ipilimumab;Knowledge;Laboratories;Libraries;Malignant neoplasm of brain;Malignant Neoplasms;Medulloblastoma;Molecular Biology;Morbidity - disease rate;mortality;Mus;mutant;Mutation;mutational status;Nivolumab;Normal tissue morphology;novel;novel therapeutics;Outcome;patient derived xenograft model;Patient-Focused Outcomes;Patients;Persons;Phase II Clinical Trials;Point Mutation;posttranscriptional;Pre-Clinical Model;Preclinical Testing;Predisposition;Prognosis;Radiation;Recurrence;Recurrent tumor;Relapse;RNA Splicing;Sampling;screening;SHH gene;single cell analysis;Small Nuclear RNA;Spliced Genes;Spliceosomes;standard care;Subgroup;Techniques;Testing;Therapeutic;Time;TP53 gene;Transcript;transcriptomic profiling;transcriptomics;Translating;tumor;tumor microenvironment;U1 small nuclear RNA;United States;Untranslated RNA;Variant;Work;World Health Organization

PROJECT_TITLE: Project 3: Exploit Immune Consequences of U1 Mutations in Sonic Hedgehog (Shh) Medulloblastoma


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Rare Diseases

PHR: NARRATIVE: PATHOLOGY AND BIOREPOSITORY CORE (CORE B) Research into brain cancer depends on the availability of tumor samples obtained from patients. These samples and the DNA, RNA, proteins, and cells derived from them (e.g. Glioma Stem-like Cell lines) are the foundation of any translational program. This Core provides the patient samples that are key to understanding and curing primary malignant gliomas.

PI_NAMEs: HUSE, JASON  (contact)

PROJECT_TERMS: Adult;Affect;analysis pipeline;biobank;Biocompatible Materials;Board Certification;Brain Neoplasms;Cancer Center;Cell Line;Cells;Central Nervous System Neoplasms;Child;Clinical;Clinical Data;Clinical Trials;clinically relevant;Collaborations;Communities;Consult;Coupled;Data Analyses;data resource;Databases;Development;Dimensions;disease model;DNA;Equipment;experience;Experimental Designs;Formalin;Foundations;Funding;Glioblastoma;Glioma;Grant;Home;Human;human tissue;improved;Infrastructure;innovation;Institution;Leadership;Link;Malignant Glioma;Malignant neoplasm of brain;Medulloblastoma;Metadata;Molecular;Molecular Analysis;molecular pathology;Molecular Profiling;molecular scale;Morbidity - disease rate;Morphology;mortality;Mus;operation;Paper;Paraffin Embedding;Participant;Pathology;Patients;Philosophy;Play;Positioning Attribute;preclinical study;Primary Brain Neoplasms;Process;Productivity;programs;prospective;Proteins;Reagent;Records;repository;Research;Research Activity;Research Personnel;Resources;RNA;Role;Sampling;Services;Site;Slide;Specimen;Specimen Handling;stem-like cell;Stream;success;Therapeutic Trials;Thinking;Time;Tissue Banks;Tissue Embedding;Tissue Microarray;Tissue Model;tissue processing;Tissue Procurements;tissue resource;Tissues;treatment strategy;tumor

PROJECT_TITLE: Pathology and Biorepository Core (Core B)


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Neurosciences;Rare Diseases

PHR: NARRATIVE: BIOSTATISTICS AND BIOINFORMATICS CORE (CORE C) Appropriate statistical analysis of data resulting from translational research is critical to the advancement and distribution of scientific information, through which the outcome of patients with malignant gliomas will be improved. The Biostatistics and Bioinformatics Core provides comprehensive biostatistical and bioinformatic expertise to ensure statistical integrity and optimize data analysis for SPORE studies. The Core incorporates sound experimental design principles in each project to enhance the interpretability of the study results, carries out data analyses using appropriate statistical methodology, and contributes to the interpretation of results via written reports and frequent interaction with project investigators.

PI_NAMEs: YUAN, YING  (contact)

PROJECT_TERMS: Address;Adoption;Animal Model;Animals;archive data;Basic Science;Biochemical;Bioinformatics;bioinformatics resource;Biometry;Cancer Center;career;Cell Line;Cells;Clinical;Clinical Trials;Clinical Trials Design;Collaborations;Communication;Computational Biology;Computer software;Conduct Clinical Trials;Coupling;Data;Data Analyses;data archive;Data Collection;data exchange;data integration;data management;Data Set;data sharing;design;Development;Drug Kinetics;Ensure;Epidemiology;Experimental Designs;experimental study;Faculty;Genomics;Guidelines;Immunologics;improved;Informatics;laboratory experiment;Lateral;Malignant Glioma;Malignant neoplasm of brain;Manuscripts;meetings;member;Methodology;Methods;Morbidity - disease rate;mortality;Outcome;Patient-Focused Outcomes;Patients;Phase;pre-clinical;Preparation;programs;Proteomics;Publications;Reliability of Results;Reporting;Reproducibility;Reproducibility of Results;Research;Research Personnel;Resources;Sample Size;Services;sound;Statistical Data Interpretation;Statistical Methods;tool;transcriptomics;Translational Research;Writing

PROJECT_TITLE: Biostatistics and Bioinformatics Core (Core C)


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PHR: NARRATIVE: ANIMAL CORE (CORE D) All SPORE Projects and the majority of the projects in the Developmental Research Program and Career Enhancement Program undertake animal experiments to test novel therapeutics. The Brain Cancer SPORE Animal Core provides expert oversight of the design and implementation of all animal experiments. Experienced personnel execute complex surgical procedures and experimental plans, ensuring consistency between experiments and investigators.

PI_NAMEs: GOMEZ-MANZANO, CANDELARIA  (contact)

PROJECT_TERMS: Animal Experiments;animal imaging;Animal Model;Animals;Biological Markers;Biology;bioluminescence imaging;Biopsy;Blood;Brain;Brain Neoplasms;cancer imaging;career;Carotid Arteries;Cell Culture Techniques;Cell Line;Cells;Cerebrospinal Fluid;Characteristics;Clinic;Collaborations;Collection;Complex;Data Analyses;Data Collection;design;Development;Diffuse intrinsic pontine glioma;Drug Delivery Systems;efficacy evaluation;Ensure;Excision;experience;experimental study;Firefly Luciferases;Funding;Gene Expression;Generations;Genetic Engineering;Genetically Engineered Mouse;Glioma;glioma cell line;Growth;Hamsters;Histology;Human;human model;Human Resources;humanized mouse;imaging facilities;Immunocompetent;Immunocompromised Host;implantation;In Vitro;in vivo;in vivo imaging;in vivo Model;Injections;Institution;Interleukin-15;Intra-Arterial Injections;Intracranial Neoplasms;Intraperitoneal Injections;Intrathecal Injections;Intravenous;Investigation;Knock-out;Label;Longitudinal Studies;Luciferases;Magnetic Resonance Imaging;Malignant neoplasm of brain;Medulloblastoma;Methodology;Methods;Mission;Modality;Modeling;Molecular;mouse model;Mouse Strains;Mus;Mutation;neoplastic cell;novel therapeutics;Operative Surgical Procedures;Oral;patient derived xenograft model;Patients;Pattern;pre-clinical;Pre-Clinical Model;preclinical study;preclinical trial;Productivity;programs;PTEN gene;Radiation;Regimen;Reproducibility;Research;Research Personnel;Resources;sample collection;Sampling;Services;skills;stem-like cell;Supratentorial;System;Tail;Techniques;Testing;Therapeutic;Time;Tissues;Toxic effect;TP53 gene;Training;Translations;Treatment Efficacy;treatment response;treatment strategy;tumor;Tumor Biology;Tumor Cell Line;tumor growth;Veins;Xenograft procedure

PROJECT_TITLE: Animal Core (Core D)


PHR: NARRATIVE: DEVELOPMENTAL RESEARCH PROGRAM Innovative translational research in brain tumors is critically dependent on the availability of funding for pilot projects. The Brain Cancer SPORE Developmental Research Program is an important source of seed funding for developmental research projects that have the potential to impact the outcome of patients with brain cancer. This program supports 6-8 novel projects per year and has become the major incubator for new translational concepts within this Brain Cancer SPORE.

PROJECT_TERMS: Advocate;Award;Biology;Brain Neoplasms;Budgets;Cancer Center;Clinical;clinical investigation;Clinical Research;Collaborations;Communication;Development;diagnostic strategy;Disease;Eligibility Determination;Ensure;Evaluation;Extramural Activities;flexibility;Fostering;Foundations;Funding;Genetic;Goals;Grant;Guidelines;improved;Incidence;Incubators;innovation;Journals;Laboratory Research;Leadership;Malignant neoplasm of brain;Monitor;mortality;Nature;neuro-oncology;novel;novel diagnostics;novel therapeutics;Patient-Focused Outcomes;Patients;Peer Review;Philanthropic Fund;Pilot Projects;Process;Prognosis;Program Research Project Grants;programs;Progress Reports;Publications;recruit;Reproduction spores;Research;Research Personnel;Research Project Grants;Resources;Selection Criteria;Source;success;translational approach;Translational Research;Tumor Biology;Underrepresented Minority;United States National Institutes of Health;University of Texas M D Anderson Cancer Center;Woman

PROJECT_TITLE: Developmental Research Program (DRP)


PHR: NARRATIVE: CAREER ENHANCEMENT PROGRAM The Career Enhancement Program (CEP) fosters the scientific development of junior investigators who intend to focus their careers on translational studies of brain tumors, and of established investigators who wish to refocus their careers on brain cancer research. The program provides funding of novel projects, and equally valuable, mentoring by senior scientists with outstanding track records. In past funding cycles, an impressive 60% of awardees have gone on to secure independent peer-reviewed grant funding, and similar results are anticipated in this renewal period. .

PROJECT_TERMS: American Association of Cancer Research;American Society of Clinical Oncology;anti-cancer research;Award;Basic Science;Brain;Brain Neoplasms;Cancer Biology;Cancer Center;career;Clinical;Clinical Investigator;clinical training;Communication;Communities;Data;Dedications;Development;Doctor of Philosophy;Education;Educational process of instructing;Ensure;Epidemiologist;Faculty;Fostering;Foundations;Funding;Goals;graduate school;Institution;Investments;Laboratories;Letters;Malignant neoplasm of brain;meetings;member;Mentors;Mentorship;Minority Groups;neuro-oncology;novel;Peer Review;Peer Review Grants;Philanthropic Fund;Physicians;Postdoctoral Fellow;Productivity;programs;Records;recruit;Research;Research Personnel;Research Project Grants;Research Proposals;Science;Scientist;Secure;Senior Scientist;skills;success;symposium;Technical Expertise;Time;Training;Translational Research;translational scientist;translational study;Tumor Biology;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;University of Texas M D Anderson Cancer Center;Woman;Women's Group

PROJECT_TITLE: Career Enhancement Program (CEP)


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: WORCESTER

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: WORCESTER POLYTECHNIC INSTITUTE

ORG_STATE: MA

PHR: Project Narrative The proposed U-RISE at Worcester Polytechnic Institute (U-RISE@Wπ) interdisciplinary training program combines course-based and individual research experiences with structured mentoring and coaching to strengthen our inclusive community and nurture the academic success of undergraduate Trainees — especially from underrepresented populations. An integrated team of Coaches, faculty Advisors, graduate Mentors, and peers will provide guidance, feedback, and resources to help Trainees acquire necessary skills and cultivate their self- efficacy while seeing the fun and excitement of research so that they may achieve their goals toward successfully completing of PhD programs in the biomedical sciences and engineering. The U-RISE@Wπ Trainees will enhance the diversity of the national workforce as they contribute their perspectives, scientific innovations, discoveries, and skillsets to improve public health.

PI_NAMEs: BILLIAR, KRISTEN L (contact);OLSEN, CARISSA ;RYDER, ELIZABETH F.

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: African American student;cohort;Communication;Communities;Dedications;Degree program;Development;Doctor of Philosophy;Ecosystem;Education;Educational Curriculum;Educational workshop;Elements;Engineering;Enrollment;Evaluation;evidence base;experience;Faculty;Failure;Feedback;Feeling;Fellowship;Female;Goals;graduate school;Graduation Rates;improved;Individual;Institution;Instruction;knowledge base;Loneliness;Mentors;Mentorship;Methods;Mission;Oral;peer coaching;Play;programs;project-based learning;Reproducibility;Research;Research Personnel;Research Training;Resources;retention rate;Review Literature;Safety;Science;Science, Technology, Engineering and Mathematics;Self Efficacy;skills;Structure;Students;success;System;Time Management;Training;undergraduate research experience;undergraduate student;Underrepresented Populations;Underrepresented Students;Writing

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Narrative The Vanderbilt Training in Gastroenterology T32 Program, through mentoring, scientific, financial, and professional support of trainees, seeks to improve the prevention, treatment, and outcomes of human digestive diseases. This Program also serves as a catalyst for collaborative and impactful research performed by a diverse workforce of junior investigators.

PI_NAMEs: PEEK, RICHARD M. (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Gastroenterology;Training

PROJECT_TITLE: Training in Gastroenterology

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-W (J1)]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Neurosciences;Pediatric

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Capitalizing on UCLA’s unique strengths, we propose continuing a cutting-edge predoctoral training program in brain and behavioral development during adolescence to produce the next generation of scholars who can advance science and ultimately, enhance the health and well-being of adolescents.

PI_NAMEs: DAPRETTO, MIRELLA ;FULIGNI, ANDREW J (contact);GALVAN, ADRIANA

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TITLE: Doctoral Training in Brain and Behavioral Development During Adolescence (UCLA BBDA)

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-R (90)]


NIH_SPENDING_CATS: Diabetes

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Obesity, diabetes and osteoporosis are increaingly prevalent metabolic diseases that are reponsible for a great burden of suffering and death as well as large healthcare expenditures in the US and throughout the world. Academic endocrine researchers are needed to better understand these diseases and to translate research findings into new and improved therapies. The Yale T32 program in Diabetes and Disorders of Metabolism is dedicated to providing young graduate students, physicians and scientists with the research training necessary to tackle these important public health problems.

PI_NAMEs: CAPRIO, SONIA ;HEROLD, KEVAN C;WYSOLMERSKI, JOHN J (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Diabetes Mellitus;Metabolic Diseases

PROJECT_TITLE: Diabetes Mellitus and Disorders of Metabolism

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: MILWAUKEE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE The goal of the project is to train a new generation of Vision Science researchers at the pre-doctoral level that are highly competent in the newest technologies and at the same time mindful of the important role of interdisciplinary, collaborative and translational research in major scientific advances. Our challenge is to expose them to the major problems that need to be solved in vision research while providing in depth training in the technologies essential for research.

PI_NAMEs: SEMINA, ELENA V (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Research Training;Training Programs;vision science

PROJECT_TITLE: Research Training Program in Vision Science

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (05)]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Motor commands to motoneurons have three components, excitation, inhibition and neuromodulation. Our goal is to implement motoneuron models on supercomputers and use the resulting computational power to reverse engineering motor neuron firing patterns to identify these three components in humans.

PI_NAMEs: HECKMAN, CHARLES  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TITLE: Supercomputer-based Models of Motoneurons for Estimating Their Synaptic Inputs in Humans

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: WINSTON-SALEM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: The incidence of alcohol abuse remains high in the United States. This training program will supply the United States with highly trained scientists who are poised to address the serious problems presented by alcohol abuse disorders.

PI_NAMEs: MCCOOL, BRIAN A (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TITLE: Multidisciplinary Training in the Biology of Alcohol Addiction

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 CC (32)]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: Aurora

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Narrative This renewal application is to support a predoctoral training program at the University of Colorado Anschutz Medical Campus in Molecular and Systems Toxicology. The program requests stipend and tuition support for 3 predoctoral trainees in years 3 & 4 of their training (for a total of 15 predoctoral trainees over 5 years). The mission of this training program is to develop students into independent scientists that have skills and knowledge to utilize cutting edge research approaches in `omics' technology to address problems presented by complex exposures to environmental agents, drugs and therapies.

PI_NAMEs: BROWN, JARED MICHAEL (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TERMS: Molecular;System;Toxicology;Training

PROJECT_TITLE: Training in Molecular and Systems Toxicology

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LWJ-S (CT)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: CORAL GABLES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative CrossROADS addresses a critical deficiency in the US academic workforce in brain aging and AD/ADRD research. Successful completion of the CrossROADS program will expand our network by adding 12 well- trained scientists from diverse backgrounds, thus enhancing our capacity to implement cross-disciplinary research to improve brain health and reduce the burden of AD/ADRD. This will have a significant impact in achieving the AD/ADRD National Plan and the NIH Healthy People 2030 goals to diversify academic workforce and fulfill the national mandate to establish health equity across US communities.

PI_NAMEs: GALVIN, JAMES E;JEAN-LOUIS, GIRARDIN ;RUNDEK, TATJANA  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Alzheimer's disease related dementia;Research;Science;training opportunity

PROJECT_TITLE: Cross-disciplinary research opportunity for training in AD/ADRD science (CROSSROADS)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-3 (J2)]


NIH_SPENDING_CATS: Data Science

ORG_CITY: PROVIDENCE

ORG_DEPT: BIOLOGY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE (3 sentences). A successful research career studying the biological systems and human diseases also involves the analysis of complex and multi-scale datasets; for example, many biomedical studies now routinely integrate -omic and cel- lular data with population-level covariates and digitized assessments of traits of interest. This predoctoral training program at Brown University will yield multiple cohorts of researchers who are uniquely interdisciplinary— work- ing at the interface of biomedical data generation and data science research — via didactic, research, and pro- fessional development opportunities that foster scientific “dual citizenship” at the faculty and student levels. This training program aligns with the NIGMS mission by training a new generation of Biological Data Scientists, as- suring the vitality and continued productivity of basic research as biological datasets expand in size, scale, and complexity.

PI_NAMEs: HUERTA-SANCHEZ, EMILIA ;RAMACHANDRAN, SOHINI  (contact);SANDSTEDE, BJORN

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TITLE: Predoctoral Training Program in Biological Data Science at Brown University

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE The main purpose of this training grant is to support short-term research training of optometric health professional students to inspire and generate interest in translational research in the trainees. The long-term goal of this training program is to increase the pool of clinicians completing advanced research training, and so to feed the pipeline of clinician scientists engaged in eye and vision research.

PI_NAMEs: CHUNG, SUSANA T;WILDSOET, CHRISTINE FRANCES (contact)

PROJECT_TERMS: Basic Science;career;Cellular biology;Clinical Research;Clinical Sciences;clinical translation;cohort;Communicable Diseases;Communities;Computer Models;Country;design;Discipline;Doctor of Philosophy;Education;Event;Eye;Fostering;Goals;Grant;Health Professional;Immunology;Individual;interest;Laboratories;Mentors;Molecular Biology;neurophysiology;Neurosciences;Online Systems;Optometry;outreach;Postdoctoral Fellow;pre-doctoral;professional students;programs;Psychology;recruit;Research;Research Personnel;Research Project Grants;Research Training;role model;Schools;Scientist;social media;Students;Talents;Training;Training Programs;Translational Research;Vision;Vision research;vision science

PROJECT_TITLE: Short-Term Research Training for Optometry Students


NIH_SPENDING_CATS: Cancer;Prevention

ORG_CITY: SAINT LOUIS

ORG_DEPT: SURGERY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Accelerating progress and building the workforce in cancer prevention and control is critical to reducing national cancer burden and reducing inequities. Increasingly, tackling excess cancer burden and improving cancer outcomes requires complex transdisciplinary and team approaches. This unique postdoctoral training program at Siteman Cancer Center aims to develop the next generation of cancer researchers and leaders who can continue to make progress to reduce the growing burden of cancer in communities.

PI_NAMEs: COLDITZ, GRAHAM A.;JAMES, AIMEE S (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Cancer Control;cancer prevention;post-doctoral training

PROJECT_TITLE: Postdoctoral Training in Cancer Prevention and Control

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-R (J1)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: BLOOMINGTON

ORG_DEPT: CHEMISTRY

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative Indiana University, Bloomington proposes to continue its development of a predoctoral training program at the Chemistry-Biology Interface named the Quantitative and Chemical Biology (QCB) Training Program. Faculty trainers from the Departments of Chemistry, Biology and Molecular and Cellular Biochemistry and interdepartmental programs in Cell, Molecular and Cancer Biology (CMCB) and Neuroscience seek to continue to provide topical interdisciplinary instructional and career development opportunities in an inclusive and supportive environment.

PI_NAMEs: GIEDROC, DAVID P. (contact)

PROJECT_TITLE: Graduate Training Program in Quantitative and Chemical Biology at Indiana University Bloomington


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Kidney Disease;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: PROJECT NARRATIVE Wilms tumor (WT) is the second most common solid pediatric cancer in children age from 2 to 4. Although WT patients have a favorable prognosis, ~50% of patients with anaplastic WT will experience recurrence. This study focuses on elucidating the molecular changes distinguishing epithelial and blastemal types of Wilms tumors and repurposing FDA-approved drugs for better treatments of children with aggressive WT.

PI_NAMEs: XU, WEI  (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: 2 year old;Age;Anaplasia;Animal Model;ATAC-seq;Biological Assay;Biology;blastema;cancer recurrence;capsule;Cell Line;cell type;Cells;Characteristics;chemotherapy;Chemotherapy and/or radiation;Child;Chromatin;Classification;Clinical;Cytarabine;Data;Development;DNA Damage;Drug Screening;effective therapy;embryonic stem cell;Enzymes;epigenetic drug;Epigenetic Process;Epithelial Cells;Epithelium;Exhibits;experience;EZH2 gene;FDA approved;genetic signature;Germ Layers;Harvest;high risk;Histologic;Histology;Histone Deacetylase Inhibitor;Implant;improved;in vivo;induced pluripotent stem cell;Kidney;Kidney Neoplasms;Lung;Malignant Childhood Neoplasm;Malignant Neoplasms;Metastatic Neoplasm to the Liver;Metastatic Neoplasm to the Lung;Modeling;Molecular;mouse model;multidisciplinary;Mus;NCAM1 gene;Neoplasm Metastasis;Nephroblastoma;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;patient derived xenograft model;patient prognosis;Patients;Pediatric Hospitals;Pediatric Oncologist;Pharmaceutical Preparations;Phase;pluripotency;progenitor;Prognosis;programs;Publications;Publishing;Recurrence;Renal Carcinoma;Resistance;Risk;Saint Jude Children's Research Hospital;screening;side effect;single cell analysis;single nucleus RNA-sequencing;single-cell RNA sequencing;Site;Solid;standard of care;stem cell biology;stem cell biomarkers;stem cell exhaustion;stem cell model;stem cells;Stromal Cells;success;Surgeon;Survival Rate;Teratoma;Testing;trait;transcriptome;Transplantation;Treatment Efficacy;treatment strategy;tumor;Tumor Cell Line;Tumor Markers;Tumor Stem Cells;Undifferentiated;Wit

PROJECT_TITLE: A New Strategy for Screening Effective Therapies for Metastatic Wilms Tumors

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-1 (J2)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: Narrative The major objective of this proposal is to understand the role that Toll-like receptor 8-activating microRNAs play in mediating fetal membrane inflammation in response to infection, and their role in mediating FM- neutrophil communication through exosome delivery. Our studies will advance our understanding of the mechanisms by which infections cause pregnancy complications, such as chorioamnionitis and preterm birth. Our outcomes have the potential of defining new mechanisms of pathology, predictors of prematurity, and therapeutic targets.

PI_NAMEs: ABRAHAMS, VIKKI M (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Acetylmuramyl-Alanyl-Isoglutamine;Agonist;Allopurinol;Bacteria;Bacterial Infections;Cells;chemokine;Chemotactic Factors;Communication;Complex;cytokine;Data;exosome;Exposure to;extracellular;Family;Fetal Membranes;Fetus;Grant;Human;IL8 gene;Immune;In Vitro;in vitro testing;in vivo;Infection;Inflammasome;Inflammation;Inflammatory;inflammatory milieu;Inflammatory Response;inhibitor;intraamniotic infection;Lipopolysaccharides;Maternal-Fetal Exchange;Mediating;Mediator;MicroRNAs;Modeling;mouse model;Mus;National Institute of Allergy and Infectious Disease;Nature;neutrophil;Neutrophil Activation;Neutrophil Infiltration;novel;Outcome;Pathologic;Pathology;Pattern recognition receptor;Peptidoglycan;Play;Pregnancy;Pregnancy Complications;premature;Premature Birth;Process;Production;receptor;Regulation;Research;Research Personnel;response;Risk;Risk Factors;Role;sensor;Signal Pathway;Signal Transduction;Site;Source;Testing;therapeutic target;tissue injury;Tissue membrane;TLR2 gene;TLR4 gene;TLR7 gene;TLR8 gene;Toll-like receptors;Uric Acid;Woman;Xanthine Oxidase;xanthine oxidase inhibitor

PROJECT_TITLE: Mechanisms regulating fetal membrane and neutrophil responses to infection

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE There is growing realization that disease susceptibility is a complex interaction between genetics, age, lifestyle choices, and environmental exposure. Training interdisciplinary scientist that can deal with this complexity, including analyzing the large amount of data necessary to quantify the different biological facets, is required if we are to develop interventions, cope with fallout from environmental accidents, and accurately inform public health officials. This predoctoral and postdoctoral training program, in collaboration with its experienced and research-intensive faculty, produces scientists with the skillset necessary to make a positive impact in addressing environmental issues using state-of-the-science mechanistic and translational toxicology.

PI_NAMEs: LAPRES, JOHN J (contact)

PROJECT_TITLE: Multidisciplinary Training in Environmental Toxicology

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS (T)]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Mental Health

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: The "Advanced Research Institute (ARI) in Mental Health and Aging” is an educational program for early- career faculty designed to help them successfully transition to independent investigators. Key elements of the program include a large network of mentors, an annual Spring Retreat, structured long-distance follow-up.

PI_NAMEs: AIZENSTEIN, HOWARD J (contact);SIREY, JO ANNE

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: 20 year old;Address;Advisory Committees;Affect;Age;Aging;Behavioral Research;Biomedical Research;Biometry;Brain;care providers;career;career development;Caring;Clinical Research;cohort;Committee Members;Communities;community based research;community engagement;Complement;Computational Science;Consultations;Data;design;Development;early-career faculty;Education;Education Projects;education research;Elements;equity, diversity, and inclusion;Faculty;Family;follow-up;Fostering;Funding;Future;Generations;geriatric mental health;Geriatric Psychiatry;Goals;Grant;Growth;Health;implementation science;Individual;innovation;Institution;Intervention;Investments;Justice;late life;Leadership;lens;Longevity;Measures;meetings;Mental disorders;Mental Health;Mentors;Mission;Modeling;Molecular;multidisciplinary;National Institute of Mental Health;next generation;older adult;Online Systems;Persons;Population;primary outcome;programs;Psychiatry;Public Health;Publications;Recommendation;recruit;Reporting;Research;Research Institute;Research Personnel;Role;Science;Scientist;Services;skills;Structure;Study Section;success;synergism;Training;translational pipeline;United States National Institutes of Health;Update;Writing

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-P (01)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Pediatric

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Infections with intracellular microbes are common, especially during pregnancy and in newborn babies. This application seeks to investigate mechanisms by which antibodies can be modified to enhance protection in newborns, with the translational goal of boosting immunity in this unique developmental window.

PI_NAMEs: ERICKSON, JOHN J. (contact)

PROJECT_TERMS: Ablation;Acetylation;Acetyltransferase;Address;Antibodies;Antibody Therapy;Antibody-mediated protection;Antigens;B-Cell Activation;B-Lymphocytes;Bacteria;Binding;Bone Marrow;Bypass;CD19 gene;CD22 gene;Cell membrane;Cells;cytokine;Data;Deacetylation;Dependence;design;Development;experimental study;Fetus;gain of function;glycosylated IgG;glycosylation;Host Defense;Human;Immune;Immunity;Immunoglobulin G;Immunologics;immunoregulation;Impairment;In Vitro;Infection;inhibiting antibody;Interleukin-10;interleukin-10 receptor;Interleukin-12;Knowledge;Life;Listeria monocytogenes;loss of function;LoxP-flanked allele;Maternal antibody;Mediating;Microbe;Molecular;Mus;Neonatal;neonate;Newborn Infant;novel vaccines;pathogen;peripheral lymphoid organ;Phenotype;Polysaccharides;Positioning Attribute;Predisposition;Pregnancy;Prevalence;Production;Recombinants;reconstitution;Regulation;Reporter;response;Rodent;Role;Shapes;sialic acid receptor;Sialic Acids;sialylation;Signal Transduction;Specificity;Structure of germinal center of lymph node;Testing;TNF gene;transcription factor;translational goal;vaccine strategy;vaccine-induced antibodies

PROJECT_TITLE: Sialylated antibody defense against intracellular infections

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Hematology;Orphan Drug;Rare Diseases

ORG_CITY: GLASSBORO

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: ROWAN UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative: Long-term outcomes of this important and forward-thinking research will reveal whether targeting aldehyde dehydrogenase (ALDH) can prevent recurrent disease progression brought on by cancer stem-like cells and whether traditional chemotherapy can be made more effective in order to increase the proportion of multiple myeloma patients who respond to this treatment. It is possible that this will have a major effect on cancer mortality rates.

PI_NAMEs: PANDEY, MANOJ KUMAR (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: Affect;African American population;aldehyde dehydrogenases;Aldehydes;Amaze;Apoptotic;B-Lymphocytes;Biochemical;Biology;Biomedical Research;black patient;Bone Marrow;Bortezomib;Cancer Etiology;cancer stem cell;career development;Caucasians;Cells;Cellular biology;Chemoresistance;chemotherapy;Clinical;clinical translation;Combined Modality Therapy;Complementary DNA;Data Analyses;Death Rate;design;Development;Disease Progression;Doxorubicin;Education;efficacy evaluation;Enzymes;experience;Faculty;Family;GLI gene;Goals;graduate student;Growth;Hematopoietic stem cells;IL2RA gene;immune modulating agents;Immunohistochemistry;Immunologics;improved;Infrastructure;inhibitor;innovation;Isatin;Knockout Mice;Laboratories;Lentivirus Vector;Liposomes;Malignant - descriptor;Malignant Neoplasms;Measures;Medical;medical schools;Medicine;Mentors;Metabolism;minority student;Modeling;Modernization;Molecular Biology;mouse model;Multiple Myeloma;Mus;nano;new therapeutic target;next generation;novel;novel therapeutics;Outcome;overexpression;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Plasma Cells;Play;Population;pre-clinical;preclinical evaluation;prevent;Process;Prognosis;Proliferation Marker;Property;Proteasome Inhibitor;Protein Isoforms;racial disparity;Recurrent disease;Refractory;Regimen;Relapse;Research;Resistance;Risk;Role;Sampling;Scientist;small molecule inhibitor;Sorbus;standard of care;stem;stem-like cell;stemness;Techniques;Testing;Thalidomide;Therapeutic;Thinking;Time;Toxic effect;Training;translational impact;Tretinoin;tumor;tumor growth;undergraduate student;Underrepresented Populations;underserved minority;Universities;Writing;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Novel Targeted Therapy for Refractory Multiple Myeloma

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-4 (SU)]


ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: HOLLINGS CANCER CENTER: OVERALL PROJECT NARRATIVE The Hollings Cancer Center at the Medical University of South Carolina coordinates scientific research to promote interdisciplinary collaborations and translation of cancer research from the bench to the bedside to the community. Through the funding of the P30 Cancer Center Support Grant, the center provides research resources in support of its scientists, and impactful engagement with its catchment area with the goal of reducing the cancer burden for the 5.2 million residents of South Carolina.

PI_NAMEs: DUBOIS, RAYMOND N. (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TERMS: Acceleration;Achievement;Address;Affect;African American;African American population;anti-cancer research;Automobile Driving;Awareness;Basic Science;bench to bedside;Black race;Cancer Biology;Cancer Burden;Cancer Cachexia;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer education;cancer health disparity;cancer prevention;CAR T cell therapy;career;career development;Caring;Catchment Area;Cause of Death;Cervical;Characteristics;Childhood;Classification;Clinic;Clinical Data;Clinical Protocols;Clinical Sciences;Clinical Trials;Collaborations;college;Colorectal;Communities;community based research;community engagement;Community Outreach;data management;Death Rate;Development;Diagnosis;Diagnostic;Disease;Doctor of Philosophy;Education;Ensure;equity, diversity, and inclusion;ethnic minority;Evaluation;Extramural Activities;Fostering;Funding;Future;Genetic;Geography;Goals;Grant;Grant Review;Head and neck structure;health disparity;high school;innovation;Institution;inter-institutional;interdisciplinary collaboration;Interdisciplinary Study;Intervention Studies;Investments;Journals;Kidney;Leadership;life span;Lung;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;Medical;member;Mission;Monitor;Morbidity - disease rate;mortality;National Cancer Institute;next generation;novel strategies;Obesity;Outcome;outreach;Participant;Patients;Peer Review;Persons;Physicians;Policies;Population;Population Heterogeneity;Population Sciences;Poverty;prevent;Preventive;Productivity;Professional Education;programs;Prostate;Protocols documentation;Public Policy;Publications;Qualifying;racial disparity;racial minority;recruit;Research;Research Infrastructure;Research Personnel;Resource Sharing;Resources;Role;Rural;Rural Community;Science;Scientist;Screening for cancer;Services;Shapes;Smoking;socioeconomics;South Carolina;Strategic Planning;Technology;Therapeutic;Therapeutic Clinical Trial;Thinking;tobacco control;Training;Training and Education;Translating;translational cancer research;translational pipeline;Translations;tumor immunology;Underrepresented Minority;Universities;US State;Vocation

PROJECT_TITLE: Medical University of South Carolina - Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: POOLE, TRAVIS I. (contact)

PROJECT_TERMS: Administrative Supplement;Advisory Committees;anti-cancer research;Area;Award;base;Basic Science;Budgets;Businesses;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cancer health equity;cancer research center director;Catchment Area;Clinical;Clinical Investigator;Collaborations;Communication;Communities;community engagement;Community Health Education;Community Outreach;Consultations;Cost Effective Management;dashboard;Data;Data Reporting;Development;Doctor of Philosophy;Documentation;Education;Environment;Equipment;Evaluation;Extramural Activities;Faculty;Faculty Recruitment;Fees;Financial Support;Fostering;Foundations;Funding;Funding Mechanisms;Funding Opportunities;Goals;Grant;Guidelines;Human Resources;improved;Infrastructure;interdisciplinary collaboration;Investments;Leadership;Malignant Neoplasms;Measures;Medical;meetings;member;Mission;Monitor;NCI Center for Cancer Research;Outcomes Research;Pilot Projects;Policies;Positioning Attribute;Process;Productivity;programs;Public Relations;Publications;recruit;Reporting;Research;Research Activity;Research Infrastructure;Research Peer Review;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Science;Services;social health determinants;South Carolina;Strategic Planning;survivorship;symposium;Technology;Training;Training and Education;tumor immunology;United States National Institutes of Health;Universities;Update;Wages

PROJECT_TITLE: Cancer Center Administration


PI_NAMEs: TOLL, BENJAMIN ANDREW (contact)

PROJECT_TERMS: Accountability;Address;anti-cancer research;Automobile Driving;Award;Biomedical Research;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer health disparity;Cancer health equity;Cancer Patient;career;career development;Career Exploration;Clinical;college;Communities;community engagement;Community Healthcare;Community Outreach;Continuing Education;data management;design;Development;Discipline;Doctor of Philosophy;early-career faculty;Education;education research;education resources;Educational Status;Effectiveness;Ensure;Evaluation;evidence base;experience;Faculty;Feedback;Fellowship Program;Fostering;Funding;Future;Goals;Grant;Health equity research;Health Professional;health training;high school;higher education;Historically Black Colleges and Universities;Home;Individual;Industry;Infrastructure;innovation;Institution;Internships;Investments;Lead;Leadership;Malignant Neoplasms;Master of Public Health;Medical;medical schools;member;Mentors;Minority;Minority-Serving Institution;Mission;NCI Center for Cancer Research;next generation;novel;Oncogenic;Oncology;Online Systems;Patient Care;Peer Review;Play;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;programs;Psychology;recruit;Research;Research Personnel;Research Training;Role;Scholars Program;Scientist;Secondary Schools;Signal Transduction;skill acquisition;South Carolina;Strategic Planning;Students;success;symposium;System;Training;Training Activity;Training and Education;training opportunity;Training Programs;undergraduate education;undergraduate student;Universities

PROJECT_TITLE: Cancer Research Training and Education Coordination


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: SHUNGU, NICHOLAS  (contact)

PROJECT_TERMS: Advocate;African American;anti-cancer research;Area;Association of American Medical Colleges;Attention;Black race;Cancer Biology;cancer care;Cancer Center;Cancer Center Support Grant;cancer health disparity;career;Catchment Area;certificate program;Climate;Clinical;Collaborations;college;Communities;community advisory board;community collaboration;community engagement;Community Outreach;Data;Dedications;Development;Discipline of Nursing;Disparity;Diverse Workforce;Doctor of Philosophy;Education;Educational Status;Ensure;Equity;equity, diversity, and inclusion;Ethnic Origin;Ethnic Population;experience;Faculty;Foundations;Future;Gender;Gender Identity;Goals;graduate student;health equity;Healthcare;high school;High School Student;Historically Black Colleges and Universities;Human Rights;improved;Individual;Infrastructure;Infusion procedures;Institution;Language;Leadership;Link;Malignant Neoplasms;Medical;Medicine;member;Mentors;Mentorship;mid-career faculty;Minority-Serving Institution;Mission;novel;Oncology;operation;Participant;Pathway interactions;Persons;Population;Positioning Attribute;Postbaccalaureate;Postdoctoral Fellow;pre-doctoral;primary care clinician;Process;programs;Race;racial population;recruit;Reporting;Research;Research Personnel;Research Support;Resource Sharing;Resources;Role;satisfaction;Scholars Program;Sex Orientation;South Carolina;Strategic Planning;success;Surveys;symposium;Time;Training;Training Activity;Training and Education;training opportunity;undergraduate student;Underrepresented Populations;United States;Universities;Woman;Work

PROJECT_TITLE: Plan to Enhance Diversity


NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy

PI_NAMEs: HOWE, PHILIP H (contact)

PROJECT_TERMS: Affect;Aneuploidy;anti-cancer;anti-tumor immune response;Area;ataxia telangiectasia mutated protein;Award;base;biobank;Biochemistry;Biological Markers;BRCA1 gene;Breast;Cachexia;Calendar;Cancer Biology;cancer care;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer health disparity;cancer therapy;career development;Catchment Area;Cell Communication;Cell Physiology;Cells;Cellular biology;cellular imaging;Chromatin;Clinical Trials;Collaborations;college;Colorectal;Communities;community advisory board;community engagement;Community Outreach;Dental;Development;Doctor of Philosophy;Education;Emerging Technologies;Equipment;Exclusion;Faculty Recruitment;Flow Cytometry;Fostering;Foundations;Funding;Funding Mechanisms;Funding Opportunities;Future;gene function;Genetic Transcription;Goals;Grant;Gynecologic;Heterogeneous-Nuclear Ribonucleoproteins;Hypoxia;Immune;immune function;Immune response;Immune Tolerance;Immunologist;Immunology;Immunotherapy;Inflammation;innovation;insight;inter-institutional;Interdisciplinary Study;interest;International;Investigation;Journals;Knowledge;Laboratories;Leadership;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;Malignant Squamous Cell Neoplasm;Medical;Medicine;meetings;member;Mentors;Microbiology;Molecular Biology;molecular imaging;multiple omics;next generation;novel;novel therapeutic intervention;Oncogenes;Oral;Pancreas;Pathway interactions;patient oriented;Peer Review;Peer Review Grants;Pharmaceutical Preparations;Phase I/II Clinical Trial;Phosphorylation;Postdoctoral Fellow;posttranscriptional;preclinical study;Process;programs;Publications;Publishing;Reader;recruit;Regulation;Research;Research Personnel;Resource Sharing;response;RNA-Binding Proteins;Role;Science;Scientific Advances and Accomplishments;Solid Neoplasm;South Carolina;Strategic Planning;Students;Therapeutic;Training;Training Programs;Training Support;Translating;translational immunology;translational pipeline;Translational Research;tumor;Tumor Biology;Tumor Immunity;tumor immunology;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Suppressor Proteins;Underrepresented Minority;United States National Institutes of Health;Universities;Woman

PROJECT_TITLE: Cancer Biology and Immunology Program


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PI_NAMEs: CARPENTER, MATTHEW J (contact)

PROJECT_TERMS: Address;Adherence;Advanced Malignant Neoplasm;Area;Behavioral;Biological;Biological Markers;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Control Research;cancer epidemiology;cancer health disparity;Cancer health equity;cancer prevention;cancer risk;care delivery;Catchment Area;Clinical Research;Clinical Treatment;Collaborations;college;Communities;community engagement;Community Health;Community Outreach;cost effective;Development;disparities in morbidity;Disparity;disparity elimination;Doctor of Philosophy;Early Diagnosis;Ensure;Faculty Recruitment;Fostering;Foundations;Funding;Future;Geography;Goals;Grant;Growth;head and neck cancer patient;Head and Neck Surgery;Health;health care delivery;health determinants;health disparity;health equity;health inequalities;health organization;Health Services Research;Health system;Human Papillomavirus;improved;Incidence;Individual;Inequity;innovation;interdisciplinary collaboration;Interdisciplinary Study;Internal Medicine;Intervention;Investments;Journals;K-Series Research Career Programs;Knowledge;lung cancer screening;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Medical;meetings;member;Morbidity - disease rate;mortality;mortality disparity;next generation;novel;novel marker;Otolaryngology;Outcomes and Health Services Research;Outcomes Research;Peer Review;Physicians;Policies;Population;population health;Population Heterogeneity;Population Research;Population Sciences;Population Study;Positioning Attribute;prevent;Prevention;programs;Publications;Publishing;Quality of life;recruit;Research;Research Personnel;Resource Sharing;Risk;Risk Behaviors;Risk Factors;Science;Scientist;Screening for cancer;Series;Shapes;smoking prevalence;social health determinants;South Carolina;Strategic Planning;survivorship;synergism;System;system-level barriers;therapy development;tobacco control;Tobacco Use Cessation;Translating;treatment trial;Underrepresented Minority;Underserved Population;Universities;uptake;Vision;Woman;Work

PROJECT_TITLE: Cancer Control Program


PI_NAMEs: DEMORE, NANCY  (contact)

PROJECT_TERMS: Advanced Malignant Neoplasm;African American;age related;anti-cancer research;anti-cancer therapeutic;Area;Award;Biological Markers;Biological Products;Biology;biomarker development;biomarker identification;Black race;Cancer Center Support Grant;cancer clinical trial;cancer risk;cancer therapy;Cannabinoids;CAR T cell therapy;career development;Catchment Area;Cells;Ceramide Signaling Pathway;Clinical;clinical trial implementation;Clinical Trials;Collaborations;Collagen;college;Combination immunotherapy;Communities;community collaboration;community engagement;Community Outreach;Critical Pathways;CXCR4 gene;Development;Disparity;Doctor of Philosophy;drug development;drug repurposing;Drug Targeting;Education;efficacy evaluation;empowerment;Entrepreneurship;Extracellular Matrix;Faculty Recruitment;Fostering;Funding;Funding Mechanisms;Future;Geography;glycoproteomics;Goals;graduate student;Growth;Hematology;Heme;Human;imaging biomarker;Imaging technology;Immunologics;Immunooncology;Immunotherapeutic agent;Incidence;Industry;innovation;Institution;Interdisciplinary Study;interest;International;Investigation;Investments;Island;Journals;KRAS2 gene;Leadership;lipidomics;Lipids;LOX gene;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Medical;meetings;Melanoma;member;Mentors;Metabolic;metabolomics;Minority;Modification;mortality;multidisciplinary;Natural Products;Neoplasm Metastasis;new therapeutic target;Non-Small-Cell Lung Carcinoma;novel;novel diagnostics;novel marker;novel strategies;novel therapeutics;Oncogenic;Oncology;Oxidation-Reduction;Patients;Pattern;Peer Review;Phase II/III Trial;Phosphotransferases;Physicians;Polysaccharides;Population;Postdoctoral Fellow;preclinical development;Prevention;Process;programs;Prostate;Publications;Publishing;recruit;Research;research clinical testing;Research Personnel;Resource Sharing;rural dwellers;Sarcoma;Science;Scientific Advances and Accomplishments;Scientist;Sea;Signal Pathway;Signal Transduction;small molecule;socioeconomics;South Carolina;Strategic Planning;Structure;Students;Surgical Oncologist;T cell infiltration;T cell response;Techniques;Technology;Testing;Therapeutic;Therapeutic Effect;Therapeutic Intervention;Therapeutic Research;therapeutic target;Tissue imaging;Training and Education;Translating;Translations;tumor;tumor growth;undergraduate student;Underrepresented Minority;Universities;Woman;women patients;working group

PROJECT_TITLE: Developmental Cancer Therapeutics Program


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Rural Health;Social Determinants of Health

PI_NAMEs: FORD, MARVELLA ELIZABETH (contact)

PROJECT_TERMS: Address;Advocacy;African American population;anti-cancer research;Area;Attitude;Belief;Big Data Methods;Black race;Breast;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Control Research;cancer diagnosis;cancer education;Cancer health equity;cancer prevention;Catchment Area;Cessation of life;Clinical;Clinical Cancer Center;Clinical Trials;Code;Collaborations;Colorectal Cancer;colorectal cancer screening;Communication;Communities;community advisory board;community collaboration;community engagement;Community Health;Community Health Education;community organizations;Community Outreach;community partners;County;Data;Data Analytics;Death Rate;Dedications;Development;Disparity;Doctor of Philosophy;Early Diagnosis;Education;Evaluation;evidence base;Evidence based intervention;Extramural Activities;Faith-based organization;Federally Qualified Health Center;Fostering;Funding;Future;Goals;Grant;Guidelines;Health;Health Educators;Historically Black Colleges and Universities;Human Papilloma Virus Vaccination;improved;Incidence;Inequity;Infrastructure;Institution;Intervention;Investments;Knowledge;Lead;Leadership;Logic;lung cancer screening;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Medicaid;Medical;medically underserved;member;Minority;Mobile Health Units;Modeling;Monitor;mortality;NCI Center for Cancer Research;Newly Diagnosed;novel;Outcome;Output;outreach;Participant;Patient Care;Persons;Pilot Projects;Policies;policy recommendation;Population;population based;Population Sciences;programs;Prostate;Public Health;Public Policy;Research;Research Activity;Research Personnel;Rest;Risk Factors;Rural;Rural Health;screening;Screening for cancer;Shapes;South Carolina;Techniques;Underserved Population;United States;United States Health Resources and Services Administration;Universities;Vision;waiver;Work

PROJECT_TITLE: Community Outreach and Engagement


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PROJECT_TERMS: Academic Medical Centers;Address;anti-cancer research;Applications Grants;Award;Basic Science;Brain;Cancer Biology;cancer biomarkers;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer health disparity;Cancer Patient;cancer risk;career;Catchment Area;Charge;Chicago;Clinical;Clinical Cancer Center;clinical care;clinical development;clinical investigation;Clinical Investigator;Clinical Research;Clinical Trials;Collaborations;college;Dedications;Development;Disease;Doctor of Philosophy;Environment;Epidemiologic Methods;Epidemiologist;Epidemiology;experience;Extramural Activities;Faculty;Faculty Recruitment;Fellowship;Foundations;Funding;Genomics;Gifts;Goals;Grant;Growth;health disparity;Heat shock proteins;high reward;high risk;Home;Illinois;immunogenicity;improved;Industry;innovation;Institution;interdisciplinary collaboration;interest;investigator-initiated trial;Investments;Ion Channel;Link;Maintenance;Malignant Neoplasms;Medical;medical schools;Medicine;Mentors;mid-career faculty;Modeling;Molecular;novel;Outcome;outreach;pandemic disease;Physicians;Pilot Projects;population health;Population Sciences;Postdoctoral Fellow;pre-clinical;professor;programs;Public Health Schools;Publications;recruit;Research;Research Activity;Research Personnel;Resources;Rhabdomyosarcoma;Role;Saint Jude Children's Research Hospital;Scholars Program;Science;Scientist;Source;South Carolina;Strategic Planning;success;Texas;The Wistar Institute;Therapeutic;Time;TP53 gene;Training and Education;Translating;Translational Research;Translations;treatment response;tumor;tumor immunology;tumor progression;United States National Institutes of Health;Universities;Variant;Vision

PROJECT_TITLE: Developmental Funds


PI_NAMEs: ROSENZWEIG, STEVEN ALAN (contact)

PROJECT_TERMS: Acceleration;Address;Advisory Committees;Aging;anti-cancer research;Applications Grants;Award;Basic Science;biobank;Bioinformatics;Biometry;Cancer Center;Cancer Center Support Grant;Cell Separation;cellular imaging;Collaborations;Computer software;Consultations;Contract Services;Core Facility;cost;cost effective;cost effectiveness;design;Development;Doctor of Philosophy;Education;Effectiveness;Emerging Technologies;Ensure;Equipment;Evaluation;Event;Experimental Designs;Faculty;Feedback;Flow Cytometry;Funding;Funding Agency;Future;Genomics;Goals;graduate student;Grant;high school;histological studies;Human Resources;Image;improved;Infrastructure;innovation;Institution;instrument;instrumentation;Investments;Knowledge;Laboratories;lipidomics;Lipids;Malignant Neoplasms;Medical;meetings;member;metabolomics;molecular imaging;NCI Center for Cancer Research;new technology;next generation;operation;Oral;Participant;Peer Review;Performance;Play;Population Sciences;posters;programs;Publications;Qualifying;Recommendation;Research;Research Personnel;Resource Sharing;Role;satisfaction;Schedule;Scientist;Services;social health determinants;South Carolina;Strategic Planning;Students;Surveys;System;Technology;Tissues;Training;Training and Education;Translational Research;undergraduate student;United States National Institutes of Health;Universities;Vision

PROJECT_TITLE: Shared Resource Management


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Rural Health

PROJECT_TERMS: Accountability;Advocacy;Advocate;anti-cancer research;Appointment;Area;authority;Basic Science;Budgets;Cancer Center;Cancer Center Support Grant;cancer health disparity;cancer prevention;cancer research center director;Caring;Catchment Area;Charge;Church;Clinical;Clinical Oncology;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;college;Communication;Communities;community advisory board;Community Outreach;Data;Decision Making;development policy;Diverse Workforce;Doctor of Philosophy;Education;Effectiveness;Ensure;Environment;Equipment;equity, diversity, and inclusion;Evaluation;experience;Financial Support;Fostering;Funding;Future;Generations;Goals;Health system;Healthcare;improved;Incentives;Infrastructure;Inherited;innovation;Institution;interdisciplinary collaboration;intervention program;Investments;Leadership;leadership development;Malignant Neoplasms;Medical;member;Mentors;Mentorship;Mission;Mobile Health Units;multidisciplinary;NCI Center for Cancer Research;next generation;Oncology;oncology service;operation;organizational structure;Patient Care;Patient-Centered Care;Patients;peer;Physician Executives;Population Sciences;Positioning Attribute;Private Sector;programs;recruit;Research;research and development;Resource Allocation;resource guides;Resource Sharing;Resources;response;Rewards;Role;Rural;Science;screening;Self-Examination;Series;Services;Site Visit;South Carolina;Strategic Planning;Structure;success;Surveys;Talents;Textiles;Time;Training;Translational Research;Universities;Update;Vaccination;Vision

PROJECT_TITLE: Leadership, Planning, and Evaluation


NIH_SPENDING_CATS: Aging;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Rural Health

PI_NAMEs: MARSHALL, DAVID T. (contact)

PROJECT_TERMS: Address;African American;Age;Biostatistics Shared Resource;Black race;Cancer Center;Cancer Center Support Grant;Cancer Patient;Catchment Area;Censuses;Clinical Cancer Center;Clinical Data;Clinical Investigator;Clinical Protocols;Clinical Research;Clinical Trials;Collaborations;Community Clinical Oncology Program;community engagement;Community Outreach;Data;data integrity;data management;data quality;data registry;data standards;Decision Making;demographics;Diagnosis;Disease;Education;Elderly;electronic data capture system;Electronics;Enrollment;Ensure;Equity;Ethnic Origin;Female;Focus Groups;Gender;Goals;Hispanic;Human;human old age (65+);Individual;informatics tool;Institution;Intake;Intervention;Intervention Trial;Investigational New Drug Application;investigator-initiated trial;Leadership;Libraries;life span;Location;Maintenance;Malignant Neoplasms;Medical;member;Minority;Minority Groups;Minority Health Research;Mission;Monitor;NCI Center for Cancer Research;older patient;Oncology;oncology trial;Participant;patient oriented;patient population;Patients;pediatric patients;peer;Performance;Population;process improvement;programs;Progress Reports;Protocols documentation;quality assurance;Race;recruit;Reporting;Research;Research Personnel;research study;Resources;Review Committee;Risk;Rural Population;rurality;Safety;screening;Services;South Carolina;Time;Training and Education;treatment trial;trend;tumor registry;underserved area;Underserved Population;Universities;welfare;Woman;women patients;Women's trial

PROJECT_TITLE: Clinical Protocol and Data Management


NIH_SPENDING_CATS: Cancer;Patient Safety

PI_NAMEs: WARREN, GRAHAM W. (contact)

PROJECT_TERMS: Administrator;authority;Authorization documentation;Biometry;Cancer Center;Cancer Center Support Grant;cancer research center director;Catchment Area;Clinical;Clinical Data;Clinical Protocols;Clinical Research;Clinical Sciences;Clinical Trials;Committee Members;community engagement;Community Outreach;Consultations;Data;data integrity;data management;Decision Making;Dedications;Disease;Doctor of Philosophy;Education;Ensure;experience;Faculty;Focus Groups;Goals;Group Meetings;human subject;human subject protection;improved;Informatics;Institution;Institutional Review Boards;interest;Knowledge;Leadership;Letters;Malignant Neoplasms;Medical;member;Monitor;operation;patient oriented;patient population;patient safety;Peer Review;Performance;Physicians;Procedures;Process;process improvement;prospective;Protocols documentation;Qualifying;recruit;Recurrent disease;Reporting;Research Personnel;Resources;Review Committee;Risk;Safety;South Carolina;System;Time;Universities;Work

PROJECT_TITLE: Protocol Review and Monitoring System


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PI_NAMEs: YOON, ANGELA JIYEON (contact)

PROJECT_TERMS: Advanced Malignant Neoplasm;Advisory Committees;African American;Animal Model;animal tissue;anti-cancer research;Applications Grants;Area;autosome;biobank;Biological Specimen Banks;Biology;Black race;Blood;Cancer Center;Cancer Center Support Grant;cancer health disparity;Cells;cellular imaging;Clinical Data;clinical diagnosis;Clinical Research;Clinical Trials;Collaborations;Communication;Community Clinical Oncology Program;Conceptions;Consent;Cooperative Human Tissue Network;cost effectiveness;data acquisition;data repository;Department chair;Development;DNA;Doctor of Philosophy;drug development;drug efficacy;early onset;Emerging Technologies;Equipment and supply inventories;ethnic diversity;Ethnic Origin;Evaluation;falls;follow-up;Freezing;Funding;Future;Goals;Grant;Hematologic Neoplasms;Histologic;histological specimens;Human;human tissue;Image;Immune;improved;insight;Institutional Review Boards;instrumentation;interest;Island;Laboratories;Leadership;Link;lipidomics;Lipids;liquid crystal polymer;Malignant Neoplasms;Medical;Medicine;meetings;member;Mission;molecular imaging;multiplexed imaging;Nature;Neurofibromatoses;Neurofibromatosis 1;new technology;Oncogenes;Pathologist;Pathology;Patients;Pattern;Peer Review;Play;Positioning Attribute;pre-clinical research;Predisposition;Prevention;programs;Protein Glycosylation;Protocols documentation;Publications;Publishing;Regimen;Reporting;Research;Research Personnel;Research Project Grants;research study;Research Support;Resource Sharing;Resources;RNA;Role;Sampling;Science;Sea;Services;Signal Transduction;Solid Neoplasm;South Carolina;Specimen;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Strategic Planning;success;Surveys;symposium;System;Techniques;technology development;Therapeutic;Tissue Donors;Tissue imaging;Tissue Microarray;Tissue Model;Tissue Stains;Tissues;Translational Research;tumor;Tumor Biology;tumor microenvironment;Tumor Tissue;Universities;Work

PROJECT_TITLE: Biorepository & Tissue Analysis Shared Resource


PI_NAMEs: HILL, ELIZABETH G. (contact)

PROJECT_TERMS: Acceleration;Adherence;Adult;anti-cancer research;Applications Grants;Bayesian Method;Behavior Therapy;bioinformatics tool;biomarker discovery;Biometry;Biostatistics Shared Resource;Body Image;Cachexia;Cancer Center;Cancer Center Support Grant;Cancer Survivor;CAR T cell therapy;Case Report Form;CD19 gene;Cell Therapy;cellular imaging;Chronic Lymphocytic Leukemia;Clinical;Clinical Cancer Center;Clinical Trials;Clinical Trials Design;Cluster randomized trial;Collaborations;Common Data Element;Communities;cost effective;Data;Data Analyses;Data Analytics;Data Collection;Data Files;data management;data pipeline;data sharing;data sharing networks;data standards;Databases;design;Development;Doctor of Philosophy;Dose;early phase clinical trial;Education;Electronics;Emerging Technologies;Ensure;Exclusion;Experimental Designs;Faculty;FAIR principles;Future;Grant;Growth;Head and Neck Cancer;Human Resources;imaging platform;improved;Infrastructure;innovation;Instruction;Leadership;Life Cycle Stages;Logic;Malignant Neoplasms;Manuscripts;Medical;meetings;member;Mentors;Mentorship;Metabolic;Metadata;Methods;Mission;Modeling;Monitor;multilevel analysis;multiple omics;NCI Center for Cancer Research;next generation;Non-Hodgkin's Lymphoma;novel;Pancreatic Ductal Adenocarcinoma;Patients;Play;Population;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Preparation;primary endpoint;Professional Organizations;programs;protocol development;Qualifying;Randomized, Controlled Trials;Report (document);Reporting;Reproducibility;Research;Research Design;Research Personnel;Research Priority;Research Project Grants;Research Support;Resolution;Resource Sharing;Resources;Role;Safety;Sample Size;secondary endpoint;Services;Site;Small-Cell Lymphoma;South Carolina;spatiotemporal;Standardization;Statistical Methods;Strategic Planning;Students;Testing;Therapeutic Intervention;tool development;Training;Training and Education;Training Programs;trait;Translational Research;Translations;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: Biostatistics Shared Resource


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Networking and Information Technology R&D (NITRD)

PI_NAMEs: LEMASTERS, JOHN J (contact)

PROJECT_TERMS: Animals;anti-cancer research;Antineoplastic Agents;Apoptosis;Area;Biological Assay;Biological Sciences;Biology;Cancer Center;Cancer Center Support Grant;Carbon Dioxide;Cell Physiology;Cell Survival;Cells;Cellular biology;cellular imaging;Clinical;Clinical Research;Collaborations;Complex;Computer software;Conceptions;Confocal Microscopy;Consult;Consultations;cytate;data acquisition;deep learning;Doctor of Philosophy;drug discovery;Educational workshop;electrical potential;Emerging Technologies;Equipment;Experimental Designs;Fluorescence;Fluorescence Resonance Energy Transfer;fluorophore;Future;Generations;Goals;Grant;Head;Human Resources;Image;Image Analysis;image processing;imager;imaging modality;imaging software;Imaging Techniques;Imaging technology;immunocytochemistry;Incubators;innovation;instrument;intermolecular interaction;intravital imaging;intravital microscopy;Ions;Label;Leadership;Learning;lectures;Leukocytes;Libraries;light microscopy;live cell imaging;Malignant Neoplasms;Manufacturer;Medical;meetings;member;Microcirculation;Microscope;microscopic imaging;Microscopy;Mitochondria;Modernization;Molecular Biology;molecular imaging;Monitor;multi-photon;multiphoton microscopy;NCI Center for Cancer Research;Necrosis;novel;Optics;Organism;Postdoctoral Fellow;practical application;Preparation;programs;protein distribution;Proteins;Protocols documentation;Publications;Quality Control;Reader;Research;Research Personnel;Research Project Grants;Research Support;Resolution;Resource Sharing;Resources;restoration;Running;Sampling;Scanning;Science;screening;second harmonic;Series;Services;Slide;Solid;South Carolina;Specimen;Strategic Planning;Structure;Students;superresolution imaging;superresolution microscopy;System;Techniques;Technology;Temperature;Three-Dimensional Imaging;three-dimensional visualization;Time;Tissue imaging;Tissues;tool;Training;Training and Education;Translational Research;Tumor Biology;ultra high resolution;Universities;Visualization

PROJECT_TITLE: Cell & Molecular Imaging Shared Resource


PI_NAMEs: LARUE, AMANDA C. (contact)

PROJECT_TERMS: Address;Advisory Committees;Animals;anti-cancer research;antibody detection;Antitumor Response;Apoptosis;Basic Science;Biological Process;Cancer Biology;Cancer Center;Cancer Center Support Grant;cancer initiation;Cell Cycle;Cell Proliferation;Cell Separation;cell type;Cells;Clinical;Clinical Trials;Collaborations;Communities;community center;community engagement;Community Outreach;Complex;Consultations;cost;cost effective;Cytometry;Data;data acquisition;Data Analyses;Detection;Development;dimensional analysis;Doctor of Philosophy;Education;Emerging Technologies;Equipment;equipment acquisition;Experimental Designs;Flow Cytometry;Fluorescence;Fluorescence-Activated Cell Sorting;forging;Future;Goals;high dimensionality;Image Cytometry;imaging system;Immune response;Immunologic Monitoring;Immunophenotyping;Immunotherapy;insight;Institution;instrument;instrumentation;Investigation;Investments;Journals;Laboratories;Lasers;Leadership;Malignant Neoplasms;Measurement;Medical;member;Membrane;method development;Methodology;Methods;Mission;Multiparametric Analysis;Nature;NCI Center for Cancer Research;Neoplasm Metastasis;next generation;novel;Patients;Peer Review;Phenotype;Population;pre-clinical;Preparation;Process;programs;Proteins;Publications;Publishing;Recommendation;Reporting;Research;Resource Sharing;Resources;Sampling;Services;single cell analysis;Sorting;South Carolina;Speed;Strategic Planning;success;Surveys;Techniques;Technology;Therapeutic Intervention;tissue culture;tool;Training;Training and Education;Training Programs;translational cancer research;Translational Research;tumor progression;Universities;Work

PROJECT_TITLE: Flow Cytometry & Cell Sorting Shared Resource


PI_NAMEs: OGRETMEN, BESIM  (contact)

PROJECT_TERMS: analog;anti-cancer research;base;Biological;Biological Models;biomarker development;Biotechnology;Blood;Brain;Cancer Biology;cancer cell;Cancer Center;Cancer Center Support Grant;Cells;Chemicals;Cholesterol;Citric Acid Cycle;Clinical;Clinical Research;Clinical Trials;Communication;Communities;Complex;cost effective;Data;Data Analyses;design;detection limit;Diglycerides;Discipline;Doctor of Philosophy;drug distribution;Drug Targeting;Educational workshop;Equipment;Experimental Designs;Fatty Acids;Fostering;Fumarates;Future;Glucose;Glutamine;Glycolipids;Glycolysis;Glycosphingolipids;Goals;Grant;Growth;hydrophilicity;Image;imaging capabilities;Immunology;improved;in vivo;inhibitor;Institution;instrument;instrumentation;interest;International;Investigation;Ions;Kidney;Leadership;lipid metabolism;lipidomics;Lipids;Liquid substance;Liver;Location;Malignant Neoplasms;mass spectrometer;Mass Spectrum Analysis;Measurement;Measures;Medical;member;metabolomics;Methodology;Mission;mitochondrial metabolism;Molecular;Molecular Analysis;NCI Center for Cancer Research;NCI-Designated Cancer Center;Nonesterified Fatty Acids;Organ;Pathway interactions;Pharmaceutical Preparations;Phospholipids;Population;Prevalence;programs;Prostaglandins;Protocols documentation;Publications;Pyruvate;Reagent;Research;Research Design;Research Personnel;Resolution;Resource Sharing;Resources;Role;Sampling;Science;Scientist;Seminal;Services;Signal Transduction;South Carolina;Specimen;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Sphingolipids;Structure;Surface;System;Technology;Therapeutic;Tissues;Training and Education;Tumor Biology;Tumor Cell Biology;tumor progression;tumor xenograft;United States;Universities;Visualization;Work

PROJECT_TITLE: Lipidomics Shared Resource


PI_NAMEs: OUYANG, JIAN  (contact)

PROJECT_TERMS: Animals;antibody detection;Antitumor Response;Applications Grants;ATAC-seq;base;Basic Science;biobank;Biological Assay;Biological Markers;Cachexia;Cancer Center;Cancer Center Support Grant;Cancer Patient;Cell Death;Cell Nucleus;cell type;Cells;Center for Translational Science Activities;ChIP-seq;Clinical;Clinical Investigator;Clinical Trials;Collaborations;community center;Companions;Computer software;Consult;Consultations;Correlative Study;cost;cost effective;Data;Data Analyses;design;Detection;Development;Diagnosis;digital;dimensional analysis;Disease;DNA;Doctor of Philosophy;drug development;Education;Educational workshop;Evaluation;Experimental Designs;experimental study;flexibility;Funding;Future;Genomics;Grant;high dimensionality;Histology;Human;Human Resources;Image Analysis;Immune response;Immunofluorescence Immunologic;improved;In Situ Hybridization;innovation;Investigation;investigator-initiated trial;Journals;Laboratories;Libraries;Medical;member;method development;Methodology;Methylation;MicroRNAs;miRNA expression profiling;Molecular;Morphology;multiple omics;Mus;nano-string;Neoplasm Metastasis;next generation sequencing;novel;novel diagnostics;novel marker;Nucleic Acids;Pathology;Patients;Peer Review;Peripheral;Pharmacologic Substance;Phenotype;Population;pre-clinical;Preparation;prognostic;programs;Protein Analysis;protein profiling;Proteins;Publications;quantitative imaging;Reporting;Research;Research Personnel;Resource Sharing;RNA;RNA analysis;Sampling;Scanning;Science;Scientist;Services;single nucleus RNA-sequencing;Slide;Source;South Carolina;Stains;Strategic Planning;tissue culture;tissue processing;Tissues;tool;Training;Training and Education;Transcript;transcriptome;transcriptome sequencing;transcriptomic profiling;transcriptomics;translational goal;Translational Research;translational scientist;Translations;treatment strategy;tumor;tumor progression;United States National Institutes of Health;Universities;Whole Blood;whole genome;Work

PROJECT_TITLE: Translational Science Laboratory Shared Resource


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative This proposal is for continuation of the highly successful Advanced Training in Nursing Outcomes Research program at Penn Nursing. We aim to develop a diverse cohort of expert nurse scientists equipped with the advanced methods and data science approaches needed to conduct rigorous research that improves patient outcomes and health equity in all the places nurses work with patients.

PI_NAMEs: BROOKS CARTHON, JACQUELINE MARGO;LAKE, EILEEN T;MCHUGH, MATTHEW D. (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: Discipline of Nursing;Outcomes Research;Training

STUDY_SECTION_NAME: Special Emphasis Panel[ZNR1 REV-N (03)]


ORG_CITY: SAN ANTONIO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: NARRATIVE Our Program Project focuses on elucidating the mechanistic underpinnings of homology-directed DNA repair (HDR) that is mediated by the tumor suppressors BRCA1-BARD1 and BRCA2 and how the 53BP1 regulatory axis restricts HDR to favor the engagement of non-homologous DNA end joining as DNA repair tool. We anticipate these endeavors to shed light on how DNA double-strand break repair pathway choice is regulated, help identify predictive biomarkers of cancer therapy response, and develop separation-of- function mutants to probe pathway mechanisms. Altogether, we will establish a mechanistic foundation to predict, intervene, and control biological outcomes of cellular responses to DNA damage.

PI_NAMEs: SUNG, PATRICK  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: access restrictions;Antineoplastic Agents;Area;BARD1 gene;Binding;Biochemical;Biochemistry;Biological;biophysical techniques;Biophysics;BRCA deficient;BRCA1 gene;BRCA2 gene;Breast;cancer drug resistance;cancer therapy;cancer type;Cell Line;Cells;Cellular biology;Chemicals;Chromosomal translocation;chromosome replication;Chromosomes;Complex;Core Facility;design;Development;DNA;DNA analysis;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA Repair;DNA replication fork;DNA Sequence;Double Strand Break Repair;drug resistance development;Environment;Enzymatic Biochemistry;Epigenetic Process;epigenetic silencing;Excision;Exhibits;experimental study;Failure;FDA approved;Foundations;Funding;gene repair;Genes;genetic profiling;Genome;Genome Stability;Goals;Health Sciences;Human;Impairment;inhibitor;inhibitor therapy;interdisciplinary approach;Ionizing radiation;Knowledge;Laboratories;Leadership;Lesion;Licensing;Ligands;Maintenance;Malignant Neoplasms;Measurement;Mediating;Minor;mouse model;mutant;Mutation;Myanmar;Neoplastic Cell Transformation;Nonhomologous DNA End Joining;novel;novel therapeutic intervention;Outcome;Ovarian;p53-binding protein 1;Pathway interactions;Patients;Pharmacotherapy;Phenotype;Polymerase;predictive marker;Preparation;prevent;Process;Production;Program Efficiency;programs;Protein Analysis;Protein Biochemistry;protein complex;protein purification;Proteins;Rad51 recombinase;Reaction;Reader;reconstitution;Regulation;repaired;Research Personnel;Research Project Grants;Resistance;Resource Sharing;response;Ribose;Services;single molecule;Somatic Mutation;stem;structural biology;Structure;synergism;Texas;Therapeutic;tool;treatment response;tumor;Tumor Suppressor Proteins;Tumor Tissue;tumorigenesis;United States National Institutes of Health;Universities

PROJECT_TITLE: Regulation of BRCA-dependent Genome Repair via the 53BP1 Axis

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RPRB-H (J1)]


NIH_SPENDING_CATS: Cancer;Genetics

PHR: NARRATIVE Our Program Project focuses on elucidating the mechanistic underpinnings of homology-directed DNA repair (HDR) that is mediated by the tumor suppressors BRCA1-BARD1 and BRCA2, and how the 53BP1 regulatory axis restricts HDR to favor the engagement of non-homologous DNA end joining as a DNA repair tool. We anticipate these endeavors to shed light on how DNA double-strand break repair pathway choice is regulated, help identify predictive biomarkers of cancer therapy response, and ultimately lead to the development of novel therapeutic strategies to treat breast, ovarian and other cancers.

PROJECT_TERMS: anti-cancer research;BARD1 gene;Binding;Biochemistry;Biophysics;BRCA1 gene;BRCA2 gene;Breast;Budgets;Cancer Center;cancer drug resistance;Cancer Etiology;cancer therapy;Cells;Chemicals;Child;Chromosomal translocation;chromosome replication;Collaborations;Communication;Communities;Complex;Consultations;Dana-Farber Cancer Institute;Department chair;Development;Disputes;DNA Double Strand Break;DNA Repair;DNA replication fork;DNA Sequence;Double Strand Break Repair;Educational workshop;Ensure;Environment;Environmental Health;Epigenetic Process;Excision;experience;experimental study;Failure;Funding;Future;Genome;Genome Stability;Goals;Grant;Health Sciences;Individual;Infrastructure;Institution;Intellectual Property;Ionizing radiation;Joints;Journals;Knowledge;Laboratories;Leadership;Lesion;Ligands;Maintenance;Malignant Neoplasms;Measurement;Mediating;meetings;member;Minor;Molecular;Molecular and Cellular Biology;Monitor;National Cancer Institute;Neoplastic Cell Transformation;Nonhomologous DNA End Joining;novel;novel therapeutic intervention;Ovarian;p53-binding protein 1;Participant;Pathway interactions;Pilot Projects;predictive marker;Preparation;prevent;Principal Investigator;Production;Productivity;programs;Progress Reports;Protein Analysis;Proteins;Publications;Publishing;Reader;Regulation;repaired;Research;Research Institute;Research Personnel;Resource Sharing;Resources;Services;Specialist;structural biology;Students;Study Section;symposium;synergism;Technology;Texas;tool;Training;treatment response;Tumor Suppressor Proteins;tumorigenesis;United States National Institutes of Health;Universities;web site;Work

PROJECT_TITLE: Admin Core:  Regulation of BRCA-dependent Genome Repair via the 53BP1 Axis


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Ovarian Cancer;Rare Diseases;Women's Health Research

PHR: PROJECT NARRATIVE DNA end resection has a key role in DSB repair and DNA replication. Any aberrations in DNA end resection can lead to genomic instability and also impact the therapeutic response to DNA damaging drugs. Our discovery of DYNLL1, which interacts with MRE11 to inhibit end resection, provides a functional link between two distinct end resecting mechanisms, with one directly controlling MRE11 activity and the other indirectly regulating Shieldin dependent end resection. Here we will continue to shed light on how functional interplay of the DNA end resection machinery and its regulatory circuitry impacts upon genome stability and sensitivity to PARPi.

PI_NAMEs: CHOWDHURY, DIPANJAN  (contact)

PROJECT_TERMS: Affect;Attenuated;BARD1 gene;Binding;Biochemical;Blood Cells;BRCA1 gene;Cancer Patient;Cell Cycle;Cells;Cicatrix;clinically relevant;Collaborations;Complex;Development;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA lesion;DNA Repair Gene;DNA replication fork;DNA-PKcs;ds-DNA;Equilibrium;Excision;Frequencies;G1 Phase;G2 Phase;Genome;Genome Stability;Genomic DNA;Genomic Instability;genomic profiles;Germ-Line Mutation;Impairment;in vivo;inhibitor;inhibitor therapy;Link;Malignant neoplasm of ovary;Mediating;Methodology;Modeling;Molecular;mutant;Mutation;Nature;next generation sequencing;Nonhomologous DNA End Joining;novel;Oligonucleotides;Oligosaccharides;p53-binding protein 1;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;Phase;Phosphorylation;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;prevent;Primary Neoplasm;recruit;Regulation;repaired;Resected;Resistance;Resistance development;Role;Serine;Serous;Single-Stranded DNA;Sister Chromatid;Site;Testing;Therapeutic;treatment response;tumor;tumorigenesis;Ubiquitination

PROJECT_TITLE: Project 1:  Role of DYNLL1 in the 53BP1 Axis of HDR Regulation


PHR: PROJECT NARRATIVE DNA end resection is a critical step in the cellular response to DNA double strand breaks (DSBs) which regulates repair pathway choice and promotes homology-directed repair (HDR). We propose to delineate novel mechanisms by which the opposing actions of 53BP1-CTC1-STN1-TEN1 (CST) and BRCA1-BARD1 regulate the activities of the long-range resection enzymes EXO1 and BLM-DNA2. Our findings will not only illuminate the mechanistic principles of DSB repair pathway choice but will also provide actionable information to help guide the development of targeted cancer therapies to treat HDR-deficient cancers and circumvent drug resistance.

PI_NAMEs: BURMA, SANDEEP  (contact)

PROJECT_TERMS: access restrictions;Attenuated;BARD1 gene;Binding;Biochemistry;Biological;biomarker development;Biophysics;BRCA deficient;BRCA1 gene;Cell Cycle;Cell Cycle Progression;cell type;Cells;Cellular biology;chemotherapeutic agent;Chromatin;Complex;Development;DNA;DNA annealing;DNA Binding;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA Repair;DNA replication fork;Double Strand Break Repair;Drug resistance;ds-DNA;endonuclease;Enzymatic Biochemistry;Enzymes;epigenetic silencing;Excision;EXO1 gene;Filament;Flap Endonucleases;Functional disorder;G1 Phase;G2 Phase;Genome;genome-wide;helicase;Human;injured;insertion/deletion mutation;Ionizing radiation;Lead;Licensing;Link;Malignant Neoplasms;Mediating;Mutagens;mutant;Mutation;Nonhomologous DNA End Joining;novel;nuclease;p53-binding protein 1;Pathway interactions;Poly(ADP-ribose) Polymerase Inhibitor;Predictive Cancer Model;Process;Rad51 recombinase;Reader;recruit;Regulation;repaired;Research;Resistance;Resource Sharing;response;restoration;Role;S phase;single molecule;Single-Stranded DNA;spleen exonuclease;Stress;structural biology;synergism;Tail;targeted cancer therapy;Therapeutic;tool;treatment response;tumor;Tumor Suppressor Proteins

PROJECT_TITLE: Project 2: BRCA1-dependent DNA End Resection and Regulation via the 53BP1 Axis


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Women's Health Research

PHR: Narrative The proposal is focused on the mechanisms of control of DNA double-strand break repair by the CST and BRCA2-DSS1 complexes. Using biochemical, structural and cell biology approaches we will investigate the mechanisms of i) RAD51 restriction by CST and ii) reversal of this restriction by BRCA2-DSS1 and also iii) the role of the extended BRCA complex in the reversal of RAD51 restriction by CST. Our results will guide the development of novel therapeutics for breast, ovarian, and other cancers.

PI_NAMEs: MAZIN, ALEXANDER V (contact)

PROJECT_TERMS: BARD1 gene;Binding;Biochemical;Biophysics;BRCA1 gene;BRCA2 gene;BRCA2 Protein;Breast;cell transformation;Cellular biology;Complex;Development;Dissociation;DNA;DNA Binding;DNA Double Strand Break;DNA replication fork;Double Strand Break Repair;Excision;Filament;Genome;Hereditary Breast and Ovarian Cancer Syndrome;Human;In Vitro;insight;Intervention;Invaded;Licensing;Maintenance;Malignant Neoplasms;Mediator;mimetics;mutant;Mutation;neoplastic cell;Neoplastic Cell Transformation;Nonhomologous DNA End Joining;novel;novel therapeutics;Nucleoproteins;Ovarian;p53-binding protein 1;PALB2 gene;Pathway interactions;presynaptic;protein complex;Proteins;Rad51 recombinase;reconstitution;Regulation;repaired;Role;Single-Stranded DNA;Solvents;Stretching;structural biology;Tail;Testing;Therapeutic;therapeutic development;Tumor Suppressor Proteins;tumorigenesis

PROJECT_TITLE: Project 3: Antagonistic Mechanisms of BRCA2 and the 53BP1 Axis in RAD51 Nucleoprotein Filament Assembly


PHR: NARRATIVE Our Program Project focuses on key aspects of a conserved DNA break repair mechanism called homology- directed repair and determining how this process is regulated by 53BP1, its associated factors, and the tumor suppressors BRCA1-BARD1 and BRCA2. The Protein Biochemistry and Enzymology (PBE) Core has overcome technical bottlenecks to be able to provide high quality protein preparations to Program Project investigators to facilitate their foundational studies. The proven expertise of the PBE Core in nucleic acid and DNA repair enzymology will prove to be crucial for the overall productivity, synergy, and success of the Program Project. 1

PI_NAMEs: KWON, YOUNGHO  (contact)

PROJECT_TERMS: Area;BARD1 gene;Biochemical;Biochemistry;Biological Assay;Biophysics;BRCA1 gene;BRCA2 gene;Cell Culture Techniques;Cell Cycle;Chromatids;Chromatin;Complex;Consultations;Dana-Farber Cancer Institute;DNA;DNA Double Strand Break;DNA Repair;DNA replication fork;Enzymatic Biochemistry;Epigenetic Process;Eukaryota;Excision;Filament;G1 Phase;Genome;Goals;graduate student;Health Sciences;In Vitro;Invaded;Joints;Link;Maps;Mediating;meetings;member;Methods;mutant;Nonhomologous DNA End Joining;nuclease;Nucleic Acid Biochemistry;Nucleic Acids;p53-binding protein 1;Pathway interactions;Postdoctoral Fellow;Preparation;presynaptic;Process;Production;Productivity;Program Research Project Grants;programs;Protein Biochemistry;protein complex;protein expression;protein protein interaction;protein purification;Proteins;Rad51 recombinase;Reaction;Reader;reconstitution;Regulation;Repair Enzymology;repaired;replication stress;Research;Research Personnel;Role;Seasons;Services;Single-Stranded DNA;structural biology;student training;success;synergism;System;Tail;Techniques;Texas;Training;Training Programs;Tumor Suppressor Proteins;Universities

PROJECT_TITLE: Core 1: Protein Biochemistry and Enzymology (PBE) Core