NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Immunization;Immunotherapy;Urologic Diseases;Vaccine Related

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Project Narrative Advanced bladder cancer has a poor prognosis, and only 20-30% of patients respond to immune checkpoint blockade. Response to the immune checkpoint inhibitor αPD-1 can be improved by adding the histone deacetylase inhibitor entinostat, but it is unknown how modulation of M-MDSCs and the neoantigen landscape can be leveraged to augment response. We hypothesize that entinostat-induced changes in M-MDSCs and neoantigen expression drive response to the combination of entinostat and αPD-1, and we seek to improve response through neoantigen vaccination.

PI_NAMEs: BECKABIR, WOLFGANG  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Affect;anti-PD-1;Antigens;Automobile Driving;Bioinformatics;cancer diagnosis;cancer immunobiology;Cancer Model;Cancer Patient;career;Caring;CD8-Positive T-Lymphocytes;Cessation of life;Clinical Trials;Collaborations;Computer software;Development;effective therapy;enzyme linked immunospot assay;Epigenetic Process;experience;Flow Cytometry;Funding;Future;Genetic;Genitourinary system;Genomics;Growth;HDAC1 gene;Histone Deacetylase Inhibitor;Human;immune checkpoint blockade;Immune checkpoint inhibitor;Immunofluorescence Immunologic;immunogenic;immunogenicity;Immunologics;Immunology;improved;In Vitro;in vivo;Knowledge;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Measures;men;migration;Migration Assay;Modeling;mouse model;Mus;neoantigen vaccination;neoantigens;Oncology;Patients;Physicians;Population;Positioning Attribute;Prognosis;Regulatory T-Lymphocyte;Research;response;Sampling;Scientist;Single Nucleotide Polymorphism;single-cell RNA sequencing;Source;Specificity;Stains;Statistical Models;subcutaneous;Survival Rate;T cell response;T-Cell Immunologic Specificity;T-Lymphocyte;Testing;Training;transcriptome sequencing;transcriptomics;Translational Research;treatment effect;tumor;Tumor Antigens;Tumor Biology;tumor immunology;tumor microenvironment;Tumor Volume;ultrasound;United States;Work

PROJECT_TITLE: Effects of entinostat and neoantigen vaccination on bladder cancer


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: LOS ANGELES

ORG_COUNTRY: UNITED STATES

ORG_DEPT: CHEMISTRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Owing to their modularity and broad applicability, transition metal catalyzed cross-coupling reactions have proven a tremendous asset to the discovery of small molecules as medicines. We aim to develop excited-state bond homolysis as a novel key step to generate highly reactive radical centers with Ni-catalysis. Ultimately, the cross- coupling methods developed as a result of this proposal will contribute to the field as a whole through their unique bond forming capabilities and selectivity.

PI_NAMEs: CUSUMANO, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TITLE: Development of excited-state bond homolysis as a key step for Ni catalysis


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: PHILADELPHIA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Chronic infections such as HIV, HCV and HBV affect half a billion people and are significant causes of morbidity and mortality. T cell dysfunction or “exhaustion” is a major immunological defect during these infections as well as in cancer and can be modeled with LCMV infection in mice. The studies proposed will define the role Tox, a key programmer of exhaustion and provide new insights into how to improve immunity during chronic infections and cancer.

PI_NAMEs: WHERRY, E. JOHN (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Address;Affect;Antigens;Binding;Binding Sites;Biological;Biology;CD8-Positive T-Lymphocytes;Cells;Chromatin;chromatin remodeling;Chronic;chronic infection;Clinical;clinical effect;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;Complex;CRISPR screen;CRISPR/Cas technology;Data;Defect;Dependence;Developmental Biology;disorder control;DNA Binding;Enzymes;Epigenetic Process;Excision;exhaust;exhaustion;Exons;flexibility;Foundations;Functional disorder;gain of function;Genes;Genetic Transcription;Genome;Genomics;Goals;Hepatitis B Virus;Hepatitis C virus;Heterogeneity;Histones;HIV;Immune response;Immunity;Immunologics;imprint;improved;in vivo;inducible Cre;Infection;insight;loss of function;LoxP-flanked allele;Lymphocytic choriomeningitis virus;Maintenance;Malignant Neoplasms;Mediating;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;novel;novel therapeutics;nuclear factors of activated T-cells;Pathway interactions;Patients;PD-1 blockade;PD-1 pathway;Persons;Play;prevent;progenitor;programmed cell death protein 1;programs;Property;recruit;Reporter;Repression;response;Role;Signal Transduction;stem cell population;T-bet protein;T-Lymphocyte;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;transcription factor;Transcriptional Regulation;Transferase;Virus Diseases;Work

PROJECT_TITLE: Temporal control of differentiation and epigenetics of Exhausted CD8 T cells by Tox

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: Columbus

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Multiple Myeloma (MM) is an incurable disease that affects vulnerable elderly adults and minorities, causing morbidity and poor quality of life. We identified the protein CD56 as a key player able to support MM growth and escape from the immune system. We propose to study how CD56 induces signaling changes and affects responses to therapies and block its activity to benefit patients with this deadly disease.

PI_NAMEs: COTTINI, FRANCESCA  (contact)

PROJECT_TERMS: Adult;Advisory Committees;Affect;American;Animal Model;Biology;career;career development;Cell Adhesion;cell growth;Cell Line;Cell Physiology;cell type;Cell-Mediated Cytolysis;Cells;Characteristics;Clinical;Clinical Sciences;Clinical Trials;Committee Members;Complement;Comprehensive Cancer Center;Cyclic AMP-Responsive DNA-Binding Protein;cytotoxicity;Data;design;Deubiquitinating Enzyme;Deubiquitination;Development Plans;Diagnosis;Dialysis procedure;Disease;Doctor of Philosophy;drug development;Elderly;Eligibility Determination;experience;Gene Expression Profile;Genetic;genomic data;Genomics;Goals;Grant;Growth;Health Care Costs;Hematology;high risk;Hospital Costs;Human;Immune;Immune Evasion;Immune response;Immune system;improved;improved outcome;In Vitro;in vivo Model;individualized medicine;Internal Medicine;Knowledge;Leadership;Learning Skill;Length of Stay;loss of function;Malignant Neoplasms;Mediating;MEKs;Mentors;Minority;Modeling;Molecular Abnormality;Morbidity - disease rate;Multiple Myeloma;Mus;Names;Natural Killer Cells;NCAM1 gene;Neurons;Ohio;Outcome;overexpression;Oxidative Regulation;Oxidative Stress;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Physicians;predictive marker;Productivity;professor;Prognosis;programs;protein degradation;Proteins;Quality of life;Recurrence;Recycling;Rehabilitation therapy;Reporting;Research;Resistance;response biomarker;Role;Science;Scientist;Signal Induction;Signal Transduction;skills;Surface;T-Lymphocyte;Testing;Therapeutic;therapeutically effective;Toxic effect;transcription factor;Translational Research;treatment response;tumor;Tumor Escape;tumor immunology;tumor microenvironment;ubiquitin C-terminal hydrolase;ubiquitin isopeptidase;Universities;Writing

PROJECT_TITLE: Investigating CD56 signaling in multiple myeloma growth and immune escape

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Cancer;Data Science;Networking and Information Technology R&D (NITRD);Skin Cancer

ORG_NAME: WISTAR INSTITUTE

PHR: Project Narrative – Biostatistics and Bioinformatics Core C Collaboration between the Biostatistics and Bioinformatics Core and the research investigators conducting SPORE-related studies will insure that the SPORE research studies will have strong bioinformatics infrastructure, high quality study designs and tailored statistical analysis plans that will provide a solid foundation for each study’s conclusions. This will ensure Scientific Rigor and enhance the impact of discoveries on the care of patients with melanoma and other skin cancers.

PI_NAMEs: GIMOTTY, PHYLLIS A. (contact)

PROJECT_TERMS: Abramson Cancer Center at the University of Pennsylvania;Address;Archives;Area;Big Data;Bioinformatics;bioinformatics infrastructure;Biological Markers;Biometry;Biostatistics Core;Biostatistics Shared Resource;career;Clinical Research;Clinical Trials;Collaborations;Data;Data Discovery;data management;Data Set;design;Development;Ensure;Environment;Epidemiology;Evaluation;experience;Experimental Designs;experimental study;Faculty;Foundations;Human Resources;Individual;Knowledge;Laboratory Study;Manuscripts;Measurement;meetings;Melanoma;member;Methodology;Methods;Pathology;Patient Care;Play;Preparation;programs;public database;Publications;Randomized;Reporting;Research;Research Activity;Research Design;Research Methodology;Research Personnel;Research Project Grants;research study;Role;Sample Size;Skin Cancer;Solid;Source;Statistical Data Interpretation;Statistical Models;study population;success;Testing;The Wistar Institute

PROJECT_TITLE: Biostatistics and Bioinformatics Core


ADMINISTERING_IC: DE

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease;Health Services;Mental Health;Mental Illness;Primary Health Care

ORG_CITY: DECATUR

ORG_NAME: VIRTUALLY BETTER, INC.

ORG_STATE: GA

PHR: Project Narrative Dental fear negatively affects the health of over 53 million American adults. Standard dental treatment (anti-anxiety medication or anesthesia) is compassionate but maintains the cycle of fear and avoidance; psychological treatments are effective but are rarely available and not easily disseminated. We propose to develop and test a suite of self-administered eHealth tools (neVR Fear the DentistTM) to treat dental fear that can be implemented in private practice dental offices throughout the U.S. and is eminently scalable.

PI_NAMEs: ADAMS LARSEN, MARGO  (contact);HEYMAN, RICHARD ELIOT;SLEP, AMY MICHELE SMITH

PROGRAM_OFFICER_NAME: ELWOOD, WILLIAM N

PROJECT_TERMS: active control;Adopted;Adult;Affect;Aftercare;American;Anesthesia procedures;Anti-Anxiety Agents;Anxiety;anxiety management;Appointment;Behavioral;Belief;Brain;Businesses;Clinic;clinical practice;Cognitive Therapy;Communication;cost;Costs and Benefits;Data;demographics;Dental;Dental Anxiety;Dental Care;Dental General Practice;Dental Offices;Dental Staff;Dentistry;Dentists;design;Development Plans;Ecosystem;Effectiveness;eHealth;Environment;Ethnic Origin;Event;Evidence based intervention;Evidence based treatment;expectation;experience;Focus Groups;follow-up;Fright;Future;Gender;Health;Healthcare;improved;Individual;innovation;Intervention;intervention effect;Learning;life span;Marketing;Mediating;medical specialties;Medicine;Modeling;National Institute of Dental and Craniofacial Research;operation;Operative Surgical Procedures;Oral health;Outcome;Pain;Patient Education;Patients;Personal Satisfaction;Pharmaceutical Preparations;Phase;preference;Preventive;Private Practice;Privatization;Procedures;psychoeducation;psychologic;Public Health;Quality of life;Quasi-experiment;Race;Randomized, Controlled Trials;Records;Reporting;Research;response;Sedation procedure;Self Administration;Services;Severities;Signal Transduction;Small Business Technology Transfer Research;social;Societies;standard care;Surgeon;System;Tablets;Testing;tool;Training;treatment group;United States Dept. of Health and Human Services;United States National Institutes of Health;Universities;uptake;virtual;virtual reality exposure;Visit

PROJECT_TITLE: Disseminable Evidence-Based Treatment for the Dental Office: Virtual Exposure Tools for Dental Fear - neVR Fear the Dentist


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Human Genome;Kidney Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: TUCSON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: NARRATIVE Chronic kidney disease occurs in more than 10% of the general population and represents a highly significant disease burden. RIGERR aims to provide substantial public health benefits by generating innovative resources and tools that will empower and accelerate current and future research across a broad range that comprehensively encompasses all kidney disease research involving genetics.

PI_NAMEs: LIANG, MINGYU  (contact)

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: Acceleration;Albumins;Albuminuria;Base Pairing;burden of illness;Cell Line;cell type;Cells;Chronic Kidney Failure;Clinical;Collection;Communities;Cre-LoxP;Creatinine;Data;Data Set;Databases;Disease;DNA;DNA Sequence;drug testing;Education and Outreach;empowerment;Engineering;Epigenetic Process;epigenetic regulation;epigenomics;Excretory function;Functional disorder;Gene Expression;General Population;Genes;Genetic;Genetic Research;Genetic Transformation;genetically modified cells;genome editing;genome wide association study;genome-wide analysis;genomic locus;Goals;Haplotypes;Health Benefit;Human;human DNA;human induced pluripotent stem cells;in vivo;induced pluripotent stem cell;innovation;Institution;Intermediate Mesoderm;Kidney;Kidney Diseases;Link;Linkage Disequilibrium;Measures;Methods;Molecular;mouse model;Nature;novel;Penetrance;Persons;Plasmids;podocyte;precision medicine;Public Health;Race;reconstitution;Renal function;Research;Research Personnel;Resources;sex;Single Nucleotide Polymorphism;Technology;Tissues;tool;Training Programs;Tubular formation;Untranslated RNA;uptake;urinary;Variant

PROJECT_TITLE: RIGERR: Resources for Investigating Genetic and Epigenetic Regulation of Renal Disease


NIH_SPENDING_CATS: Cancer;Clinical Research;Immunotherapy;Precision Medicine;Skin Cancer

PHR: Project Narrative - Project 1 Despite the recent progress in immune checkpoint inhibition (ICI)-based therapies, the patient response rate is low. Rationale-based biomarker development is urgently needed to stratify responders and non-responders, thereby providing decision-enabling information to clinicians and patients. The study of tumor- and macrophage- derived exosomes proposed in this application will unveil novel mechanisms of immune suppression, and help develop a quantitative liquid biopsy-based tool that enables clinicians to predict patient response to ICI-based therapies.

PI_NAMEs: GUO, WEI  (contact)

PROJECT_TERMS: Academia;alternative treatment;anti-CTLA4 antibodies;anti-PD-1;anti-PD1 antibodies;anti-PD1 therapy;Biological Assay;Biological Markers;biomarker development;Blood;cancer type;CD8-Positive T-Lymphocytes;Cell Physiology;Cell secretion;checkpoint inhibition;Circulation;Clinical;clinical application;clinical decision-making;clinical development;clinical diagnostics;clinical practice;clinically relevant;Coculture Techniques;Combined Modality Therapy;Data;Development;Diameter;Dimensions;Encapsulated;exhaustion;exosome;experimental study;extracellular;Foundations;Future;Goals;humanized mouse;immune checkpoint;Immune checkpoint inhibitor;immune resistance;Immunologics;Immunosuppression;Immunotherapy;improved;improved outcome;In Vitro;Individual;Industry;Infrastructure;Institution;interest;Intervention;ipilimumab;Knowledge;Lipids;liquid biopsy;Macrophage;Measurement;Measures;Mediating;Melanoma;Melanoma Cell;Melanoma patient;Metastatic Melanoma;Methods;mouse model;Mus;Mutation;Myeloid Cells;nanosized;Nature;neoplastic cell;Nivolumab;novel;novel therapeutic intervention;Outcome;patient derived xenograft model;patient response;Patient Selection;patient stratification;Patient-Focused Outcomes;Patients;pembrolizumab;personalized immunotherapy;Plasma;Play;predicting response;Prediction of Response to Therapy;predictive marker;prevent;programmed cell death ligand 1;programmed cell death protein 1;Proliferating;Resistance;responders and non-responders;response;Role;Sampling;Sensitivity and Specificity;Series;Skin Cancer;System;T cell infiltration;T-Cell Proliferation;T-Lymphocyte;Testing;Therapeutic;Time;tool;Toxic effect;treatment optimization;tumor;tumor growth;tumor progression;Tumor Promotion;Tumor Tissue;Tumor-associated macrophages;Validation;Vesicle;Work

PROJECT_TITLE: Targeting exosomal PDL1 to improve immunotherapy


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: While medication is recognized as the most effective treatment for opioid use disorder (OUD), it remains under-utilized within VA. In 2018, of more than 70,000 VA patients diagnosed with OUD, just 35% received a medication to treat the disorder. Rural patients, who comprise 23% of all VA patients, are particularly underserved. A primary reason for this is that many rural Veterans reside prohibitively far from VA facilities that offer specialty substance use disorder treatment. While primary care services are more readily available to rural Veterans through VA community-based outpatient clinics (CBOCs), within VA, the large majority of prescribing for OUD occurs within the context of specialty substance use disorder treatment settings, rather than primary care. Thus, enhancing rural patients’ access to OUD medication hinges on the extension of prescribing to rural, primary care settings. The over-arching research aim of this career award is to develop a strategy that supports the implementation of buprenorphine treatment in rural VA primary care settings.

PI_NAMEs: WYSE, JESSICA JASMINE (contact)

PROJECT_TERMS: access disparities;addiction;Address;Administrator;Affect;Alaska;Ambulatory Care Facilities;Applied Skills;Award;Buprenorphine;buprenorphine treatment;care providers;career;Cessation of life;Clinic;Clinical;Communities;community based care;Community Healthcare;Data;design;Diagnosis;Disease;Disparity;Drug Metabolic Detoxication;effective therapy;evidence base;experience;FDA approved;formative assessment;health care availability;health care disparity;Idaho;implementation barriers;implementation design;implementation science;implementation strategy;improved;Injectable;innovation;Interview;K-Series Research Career Programs;Knowledge;Locales;Location;medical specialties;medication for opioid use disorder;Mentors;Mentorship;Methadone;Methodology;Methods;military veteran;Minority;mortality;Multicenter Trials;Naltrexone;Opioid;opioid epidemic;opioid use disorder;Oregon;Overdose;Patients;Pharmaceutical Preparations;Pharmacotherapy;pilot test;pilot trial;prescription opioid;Primary Care;primary care services;primary care setting;programs;Recording of previous events;Research;Research Personnel;Research Support;Resources;Retrospective cohort study;Rural;rural area;Rural Community;rural disparities;rural patients;Sampling;scale up;Substance Use Disorder;success;Time;Training;uptake;urban area;Veterans;Vulnerable Populations;Washington

PROJECT_TITLE: Expanding access to opioid use disorder treatment with buprenorphine in rural primary care settings

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Childhood Injury;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Unintentional Childhood Injury

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative The brain damage incurred by individuals with periventricular leukomalacia (PVL) often leads to visual processing impairments, which may be more severe when the thalamus or thalamo-cortical connections are affected. The studies outlined in this proposal will use a multimodal neuroimaging approach to characterize the morphometry of thalamic nuclei and integrity of visual thalamo-cortical networks to determine how they contribute to the observed visual dysfunctions in individuals with PVL. The results from these studies will advance our understanding of the impact early white matter injury has on the visual thalamo-cortical networks and functional vision in persons with PVL, ultimately providing a set of neuroimaging and behavioral targets that may be used to develop effective habilitation strategies for these individuals in the future.

PI_NAMEs: BAUER, CORINNA M (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: 3-Dimensional;Address;Affect;age effect;Anisotropy;Anterior;Atlases;Atrophic;Behavior;Behavioral;behavioral outcome;Bilateral;Biological Markers;Brain;Brain Hypoxia-Ischemia;Brain Injuries;Cell Nucleus;Cerebral cortex;Characteristics;cohort;Communication;Complex;Data;Development;Diffuse;Diffusion;Diffusion Magnetic Resonance Imaging;evidence base;Functional Magnetic Resonance Imaging;Future;Gender;Geniculate body structure;Goals;gray matter;Habilitation;Histologic;hypoxic ischemic injury;Image;Impairment;Individual;Infant;Injury;insight;Intervention;Link;Long-Term Effects;Magnetic Resonance Imaging;Maps;Measures;Methodology;Modality;Modeling;morphometry;multimodal neuroimaging;multimodality;Myelin;myelination;neuroimaging;neuron loss;Oligodendroglia;Outcome;Outcome Measure;Parents;Perinatal Hypoxia;Periventricular Leukomalacia;Persons;Predisposition;Premature Infant;preservation;Process;prognostic;Pulvinar structure;recruit;Regression Analysis;Resolution;Rest;Retrograde Degeneration;segregation;Series;Severities;Survivors;Testing;Thalamic Nuclei;Thalamic structure;Therapeutic;tractography;Vision;Visual;visual dysfunction;Visual impairment;visual processing;Water;white matter;white matter injury

PROJECT_TITLE: Thalamo-cortical circuitry in PVL


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Skin Cancer

PHR: Project Narrative – Project 2 We have identified autophagy to be a major mechanism of resistance to melanoma therapy, and an attractive target for new drugs in melanoma and other cancers. This proposal will address a major unanswered question: Can targeting autophagy enhance the effectiveness of immunotherapy in melanoma? Knowledge gleaned from this work will provide a fundamental understanding of how autophagy inhibition can improve the response rate of immunotherapy, and should lead to development of a potentially new treatment regimen for advanced melanoma patients that could improve survival in future clinical trials.

PI_NAMEs: AMARAVADI, RAVI K (contact)

PROJECT_TERMS: Address;Affect;anti-CTLA4;anti-PD-1;anti-PD1 antibodies;Antineoplastic Agents;Attention;Autophagocytosis;Biological Markers;Biopsy;Biotechnology;BRAF gene;cancer cell;CD8-Positive T-Lymphocytes;CD8B1 gene;cell type;Cells;checkpoint inhibition;Chemicals;chemotherapy;Chloroquine;Clinic;Clinical;clinical investigation;Clinical Research;Clinical Trials;clinically relevant;Collaborations;Data;Dendritic Cells;Development;drug development;Effectiveness;Future;Generations;Genetic;genetic analysis;Glean;Goals;Histologic;Hydroxychloroquine;Imaging technology;Immune;Immune checkpoint inhibitor;Immunity;Immunologic Tests;Immunotherapeutic agent;Immunotherapy;Impairment;improved;In Vitro;in vivo;inhibition of autophagy;inhibitor;Institution;Interferon Activation;Interferons;ipilimumab;Knockout Mice;Knowledge;lysosomal proteins;Macrophage;Macrophage Activation;Malignant Neoplasms;Measures;MEK inhibition;Melanoma;Melanoma patient;Melanoma Tumor;Modeling;Molecular Target;mouse model;Mus;mutant;Myelogenous;Myeloid Cells;neoplastic cell;new therapeutic target;next generation;Nivolumab;novel;novel strategies;novel therapeutic intervention;Pathway interactions;Patients;Phase I/II Trial;Phenotype;Plasma;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;preclinical study;preclinical trial;Proteome;randomized trial;Refractory;Regimen;Resistance;resistance mechanism;response;response biomarker;Safety;Sampling;Series;Signal Transduction;Skin Cancer;Specificity;Systems Biology;T-Lymphocyte;targeted treatment;Techniques;Testing;therapy resistant;thioesterase PPT1 gene product;Treatment Protocols;tumor;tumor growth;tumor microenvironment;Tumor-associated macrophages;Tumor-infiltrating immune cells;Work

PROJECT_TITLE: Targeting autophagy to enhance immune checkpoint inhibition


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Neurodegenerative;Neurosciences

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: We expect this work to provide new insight into the cellular regulation of protein translation by eEF2K and provide critical advancement in understanding various eEF2K-driven pathologies.

PI_NAMEs: DALBY, KEVIN N (contact);GHOSE, RANAJEET

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Affect;Alzheimer's disease related dementia;Automobile Driving;Binding;Binding Sites;Biochemistry;Biological;Biology;Calmodulin;cell growth regulation;Cells;cellular targeting;Chemicals;Chronic;Complex;Data;Disease;Disparate;Dissociation;Divalent Cations;Docking;Enzyme Kinetics;Funding;Goals;Guanosine Triphosphate Phosphohydrolases;human disease;immunoregulation;In Vitro;inhibitor;innovation;insight;Invaded;Kinetics;Learning;Length;Link;Malignant Neoplasms;Mammalian Cell;Mass Spectrum Analysis;Measurement;Measures;Mediating;Memory;Messenger RNA;Modeling;Molecular Conformation;Neoplasm Metastasis;Nerve Degeneration;Nervous System Trauma;Neurodegenerative Disorders;Neurologic;novel therapeutic intervention;Nucleotides;Nutrient;Nutrient availability;Output;Parkinson Disease;Pathology;Pathway interactions;Phosphorylation;Phosphotransferases;Post-Translational Protein Processing;Process;Property;Protein Biosynthesis;Protein Kinase;Proteins;Publishing;Regulation;Research;Resolution;Ribosomes;Role;sensor;Signal Transduction;Site;small molecule;spatiotemporal;Stimulus;Stress;Structure;Synapses;Techniques;Testing;Therapeutic;Translations;tumorigenesis;Work;X-Ray Crystallography

PROJECT_TITLE: Regulation of eEF-2K an Energy and Nutrient Sensor

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Pediatric

ORG_CITY: NORTHRIDGE

ORG_DEPT: PEDIATRICS

ORG_NAME: CALIFORNIA STATE UNIVERSITY NORTHRIDGE

PHR: Project Narrative Educational Modules to Broaden Academic Research Cultures (EMBARC) is relevant to public health and the mission of NIH/NIGMS because it innovatively leverages cultural frameworks to train and promote transfer of underrepresented minority (URM) community college (CC) students to biobehavioral research career fields at an early and critical period of professional and scientific development. We anticipate EMBARC trainees will be equipped to succeed in biobehavioral research contexts and address the complex health needs of a rapidly diversifying U.S. population. Our approach includes rigorous testing of culturally-informed educational activities and modules through a partnership with the largest community college district within the largest system of higher education in the country (Los Angeles Community College District [LACCD], California Community Colleges Chancellor’s Office [CCCCO]) and distribution nationwide with some of the largest scientific organizations for URM students representing biobehavioral science (ABRCMS, APA, SACNAS) to maximize outreach and sustainability of our efforts to diversify the scientific workforce.

PI_NAMEs: GUAN, SHU-SHA ANGIE (contact);MALONE, CINDY SUE;SAETERMOE, CARRIE L;VASQUEZ-SALGADO, YOLANDA

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Academic achievement;Address;American Psychological Association;Behavioral Research;Behavioral Sciences;biobehavior;Biomedical Research;California;Capital;career;career networking;CCL7 gene;Censuses;community college;Complex;Control Groups;Country;critical period;Data;design;Development;Disparity;Education;Educational Activities;Educational workshop;Enrollment;Ensure;expectation;experience;experimental group;First Generation College Students;Fostering;Health;Health Disparities Research;health disparity;Health equity research;higher education;Hispanic Americans;Home;Individual;Infrastructure;innovation;Institution;Intention;interest;Knowledge;Learning Module;Learning Skill;Los Angeles;Mentors;Mexican Americans;Minority Groups;minority student;Mission;Modeling;National Institute of General Medical Sciences;National Research Council;Native Americans;online repository;outreach;Pathway interactions;peer;Population;Positioning Attribute;Professional Organizations;programs;Public Health;public repository;Research;research and development;Research Training;Resources;Risk;Role;role model;Science;science education;scientific organization;Scientist;Self Efficacy;Series;skills;social;Societies;Students;success;symposium;System;Testing;theories;Trainers Training;Training;Training Activity;Training Programs;Travel;undergraduate research;undergraduate student;Underrepresented Minority;underrepresented minority student;United States National Institutes of Health;Universities;university student;Vision;Work


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: NARRATIVE Circadian changes in neuronal action potential activity are required to regulate the daily fluctuations in sleep/wake cycles, hormone production, cardiovascular output, metabolism, and other physiological functions essential to human health. The goal of this research is to understand the ion channel properties, interactions, and functional consequences that set these circadian changes in action potential activity in the central clock of the brain, focusing on a stereotypical set of partnerships formed between BK channels and their Ca2+ channel activators. The results will reveal how these channels work together during the action potential to control firing, and how dysregulation of their properties and interactions contribute to circadian, sleep, and seizure disorders.

PI_NAMEs: LEDERER, WILLIAM JONATHAN (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Action Potentials;Affect;Alternative Splicing;Behavior;Behavioral;Biochemistry;Biophysical Process;Brain;Cardiovascular system;Cells;circadian;circadian pacemaker;Circadian Rhythms;Code;Complex;Coupling;Data;Dependence;Electroencephalography;Electrophysiology (science);Epilepsy;Evoked Potentials;Exhibits;Funding;gain of function mutation;Goals;Health;Hormones;Human;Hypothalamic structure;Ion Channel;large-conductance calcium-activated potassium channels;Link;Mammals;Membrane;Metabolism;Modeling;Molecular;multi-electrode arrays;Mus;Mutation;Nervous System Disorder;neural;Neurologic Dysfunctions;Neurons;novel;Outcome;Output;Pathogenicity;Patients;Periodicity;Physiological;Physiology;Post-Translational Protein Processing;Potassium Channel;Production;Property;reconstitution;Regulation;Research;RNA Splicing;Role;Ryanodine Receptor Calcium Release Channel;RyR2;Seizures;Shapes;Sleep;Sleep Disorders;sleep pattern;Sleep Wake Cycle;Source;suprachiasmatic nucleus;System;Testing;Time;Transgenic Mice;Variant;voltage;Work

PROJECT_TITLE: Daily Regulation of Ionic Currents


NIH_SPENDING_CATS: Cancer;Clinical Research;Immunotherapy;Lymphatic Research;Skin Cancer

PHR: Project Narrative – Project 3 Patients with high-risk Stage II melanoma have an unacceptably high mortality rate with surgical treatment alone. In this study, we will test the hypothesis that neoadjuvant immunotherapy can be used to reshape the tumor microenvironment in the draining lymph node to limit or eradicate the disseminated malignant cells, thus, increasing cure rates. We will determine the clinical and immunological impact of neoadjuvant anti-PD1 antibody therapy in high risk clinical Stage II melanoma and identify new rational combinations for high-risk Stage II melanoma.

PI_NAMEs: HERLYN, MEENHARD F (contact)

PROJECT_TERMS: Agonist;anti-PD-1;anti-PD1 antibodies;anti-PD1 therapy;anti-tumor immune response;antigen-specific T cells;Biological;Biological Assay;Biology;Blocking Antibodies;Blood;cancer cell;cancer infiltrating T cells;Cell Communication;Cells;Cellular biology;Clinical;clinical effect;clinical practice;Clinical Research;clinical risk;Clinical Trials;clinically significant;cohort;Cutaneous Melanoma;Data;Death Rate;Defect;Dendritic Cells;design;Development;Disease;Distant;draining lymph node;exhaust;exhaustion;Future;Gatekeeping;Genetic Transcription;Goals;Health;Hematogenous;Hematogenous Spread;high risk;Human;humanized mouse;Immune;immune health;immune resistance;Immunity;Immunologic Surveillance;Immunologics;Immunophenotyping;Immunotherapy;improved;improved outcome;instructor;Investigation;Leadership;Localized Disease;lymph nodes;Lymphatic;Lymphatic Metastasis;Lymphatic Spread;Lymphatic System;Macrophage;Malignant Neoplasms;Melanoma;Metastatic Melanoma;Metastatic Neoplasm to Lymph Nodes;Modeling;mouse model;Mus;Myelogenous;Myeloid Cells;Neoadjuvant Therapy;Neoplasm Metastasis;novel;Operative Surgical Procedures;Organ;Outcome;Pathogenesis;Pathologic;patient derived xenograft model;Patients;PD-1 blockade;pembrolizumab;peripheral blood;Phase II Clinical Trials;phase II trial;Pliability;Population;Positive Lymph Node;pre-clinical;prevent;Primary Neoplasm;Productivity;Randomized;Recurrence;Recurrent disease;Research Design;Research Personnel;resistance mechanism;response;restraint;Role;Sampling;sensor;Sentinel Lymph Node;Shapes;Skin;Skin Cancer;Surveys;survival outcome;T-Lymphocyte;Testing;therapy resistant;Tissues;treatment response;tumor;Tumor Antigens;Tumor Burden;tumor microenvironment;Tumor Tissue;tumor-immune system interactions;Work

PROJECT_TITLE: Neoadjuvant immunotherapy approaches to early stage melanoma


NIH_SPENDING_CATS: Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: This project will accelerate biomedical research by enabling scientists to systematically access and utilize critical scientific information at the interface of chemistry and biology. This information will be useful for research and teaching in multiple fields, including pharmacology, drug discovery, computational chemistry, and machine learning.

PI_NAMEs: GILSON, MICHAEL K. (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Acceleration;Area;Artificial Intelligence;Benchmarking;Binding;Binding Proteins;Biological;Biology;Biomedical Research;Cell Physiology;Certification;Chemicals;Chemistry;Communities;computational chemistry;Computer software;Data;data management;data preservation;data resource;data reuse;Data Set;Disease;Documentation;Drug Design;drug discovery;drug repurposing;Educational process of instructing;Educational workshop;Electronic Mail;experience;FAIR principles;Government;high school;Human;improved;Information Resources;interoperability;journal article;Knowledge;knowledgebase;Legal patent;Ligands;Link;Machine Learning;Measurement;Measures;Methods;Molecular Weight;Natural Language Processing;open source;Organism;outreach;Pathway Analysis;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacology;Physicians;Practice Management;preservation;protein function;protein structure;Proteins;Publications;Publishing;Readability;Recommendation;repository;Research;Research Personnel;Resources;Science;Scientist;small molecule;Software Design;Students;teacher;technology development;Testing;tool;Training;trend;trustworthiness;Twitter;Universities;Update;usability;Vocabulary;web site;Work

PROJECT_TITLE: BindingDB: An Open Knowledgebase of Protein-Small Molecule Interactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T(55)R]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Cerebrovascular;Clinical Research;Hematology;Infectious Diseases;Nanotechnology;Neurosciences;Prevention;Sepsis;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ROCHESTER

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Cognitive impairment is a common debilitating outcome of sepsis with an unknown mechanism. The study of brain injury in sepsis and other forms of systemic inflammation is limited by a lack of in vitro tools that model the interface between the blood and brain. This project will address this unmet need by building a human neurovascular unit chip where circulating factors are introduced on the `blood side' and a microglia report on inflammatory status on the `brain side.'

PI_NAMEs: ENGELHARDT, BRITTA ;GABORSKI, THOMAS R;MCGRATH, JAMES L (contact);SINGER, BENJAMIN HERSCHEL;WAUGH, RICHARD E

PROGRAM_OFFICER_NAME: YABE, IDALIA MONTANO

PROJECT_TERMS: Affect;Alleles;Animal Model;Animals;antibody inhibitor;Apolipoprotein E;apolipoprotein E-3;Astrocytes;Biological Assay;Biological Models;Blood;Blood - brain barrier anatomy;Blood brain barrier dysfunction;blood-brain barrier function;blood-brain barrier permeabilization;Brain;brain endothelial cell;Brain Injuries;Cell Culture System;Cell Line;Cells;cerebrovascular;Complex;Critical Care;Critical Illness;design;Development;Devices;Diagnostic;Diffusion;digital;Disease;Encephalitis;Encephalopathies;Endothelium;Engineering;Environment;Enzyme-Linked Immunosorbent Assay;Exhibits;experience;Exposure to;Extravasation;Fluorescence;Foundations;Gene Expression Profiling;Genetic Transcription;Glass;glial activation;Glycocalyx;Goals;Hematological Disease;Hematology;Hemoglobin;Heparin Lyase;Human;human induced pluripotent stem cells;Impaired cognition;In Vitro;in vivo;induced pluripotent stem cell;Infiltration;Inflammation;Inflammatory;innovation;Intervention;Invaded;Leucocytic infiltrate;Leukocytes;Lipoproteins;live cell imaging;Matrix Metalloproteinases;Measurement;Membrane;Microfabrication;Microglia;microphysiology system;Microscopic;Microscopy;Modeling;Molecular;Monitor;monocyte;multidisciplinary;mutant;Myeloid Cells;nanomembrane;neuroinflammation;neurovascular unit;neutrophil;Nuclear;Optics;Outcome;Pathway interactions;Pattern;Pericytes;Permeability;pharmacologic;Phase;Physiological;Play;Population;Porosity;pre-clinical;preclinical study;prevent;Property;protein expression;Protein Secretion;Proteins;Reporter;Reporting;Resolution;response;Risk;Risk Factors;Role;S100A8 gene;sensor technology;Sepsis;septic patients;Side;Signal Transduction;Silicon;solute;stem cells;Survivors;System;Systemic infection;systemic inflammatory response;Testing;therapy development;Thick;Tissue Microarray;tool;trafficking;Validation;Work

PROJECT_TITLE: The µSiM-hNVU - a human BBB platform for the study of brain injury mechanisms during systemic infection


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Mental Health;Prevention;Substance Misuse;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: SEATTLE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Sexual aggression is a significant public health concern and is closely linked with men’s sexual misperception. There is an urgent need for a comprehensive examination of the underlying mechanisms that contribute to sexual misperception. A better understanding of risk factors and causal pathways implicated in sexual misperception and sexual aggression has the potential to inform intervention and prevention efforts.

PI_NAMEs: SMITH, LAUREN MICHELLE (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Acute;Address;Adverse effects;alcohol effect;alcohol involvement;alcohol myopia;Alcoholic Intoxication;Alcohols;analog;Attention;Attitude;Bacterial Artificial Chromosomes;Behavior;Belief;Characteristics;Clinical;Consent;Cues;Development;directed attention;drinking;Encapsulated;Ensure;Environment;Etiology;Evaluation;experience;Failure;fictional works;field study;Individual;information processing;interest;Intervention;Intoxication;Investments;Knowledge;Link;Literature;male;man;Measures;Mediating;men;Methods;Modeling;Nature;Participant;participant safety;Pathway interactions;Patient Self-Report;Penetration;Perception;Peripheral;Persons;Prevalence;Prevention;Process;programs;Public Health;Research;Research Personnel;Risk Factors;risk prediction;Role;Scientist;sex;Sex Behavior;sexual aggression;sexual assault;sexual encounter;Sexual Partners;sexual relationship;skills;sobriety;Structure;theories;therapy design;Training;undue influence;willingness;Woman;Work;Writing;young adult

PROJECT_TITLE: A Field Study Examining the Effects of Alcohol, Bar Environment & Beliefs on Sexual Misperception, a Precursor to Sexual Aggression


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Skin Cancer

PHR: Project Narrative – Developmental Research Program The Development Research Program of the Wistar/UPenn SPORE will promote translational melanoma and skin cancer research by providing a mechanism for stimulating grant applications for pilot projects. The applications go through committee review, with formal procedures for monitoring progress and ensuring integration within the SPORE. Pilot projects have a potential to make a large impact on melanoma and skin cancer patient care once they advance to full projects or to externally-funded grants.

PROJECT_TERMS: anti-cancer research;Applications Grants;Cancer Center;cancer research center director;Development;Ensure;expectation;Extramural Activities;Faculty;Fostering;Funding;Future;Goals;Grant;high standard;Institution;interest;Measures;Melanoma;minority scientist;Monitor;Paper;Patient Care;Peer Review;Pilot Projects;Procedures;Process;Program Development;programs;Progress Reports;Publications;recruit;Research;research and development;Research Personnel;Research Project Summaries;research study;Resources;Review Committee;Skin Cancer;Skin Carcinoma;success;The Wistar Institute;Underrepresented Minority;Woman;Writing

PROJECT_TITLE: Developmental Research Program


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome;Prevention

ORG_CITY: GAINESVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE The human pathogen Streptococcus mutans is the major bacteria associated with dental caries. In this application, we will investigate the mechanisms utilized by S. mutans to survive under high zinc stress and determine how the use of zinc-containing dental hygiene products affects survival of bacteria associated with oral health or disease. Finally, we will explore the therapeutic potential of a S. mutans protein that confers zinc tolerance for the prevention and treatment of dental caries.

PI_NAMEs: LEMOS, JOSE A (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Address;Affect;Animal Model;Anti-Inflammatory Agents;anticaries;antimicrobial;Area;ATP phosphohydrolase;Bacteria;Bioinformatics;Biological;biological adaptation to stress;Calculi;Cells;Computer Assisted;Data;dental biofilm;Dental caries;Dental Hygiene;Dental Plaque;Development;Disease;Docking;Drug Design;Formulation;Functional disorder;Gingivitis;Goals;Halitosis;Health;Healthcare;Homeostasis;Human;human pathogen;inhibitor;innovation;Investigation;Ions;Life;Light;Mediating;Metals;microbial;Microbial Biofilms;Microbiology;microorganism interaction;Mind;Modality;Modeling;Molecular;Mouth Diseases;Mouthwash;multidisciplinary;Mutation Analysis;Names;new therapeutic target;novel;Oral;oral bacteria;oral biofilm;oral care;Oral health;oral microbial community;oral microbiome;oral streptococci;pathogen;Pathway interactions;Pharmaceutical Chemistry;Physiological;prevent;Prevention;Property;Proteins;public database;rational design;Rattus;Research;Research Personnel;resident commensals;Role;Saliva;Salivary;Salts;Shapes;Source;Streptococcus;Streptococcus mutans;Stress;Structure;Synthesis Chemistry;System;Therapeutic;Therapeutic Agents;therapeutic target;Toothpaste;Toxic effect;Trace metal;transcription factor;transcriptome;Zinc

PROJECT_TITLE: Mechanisms of Metal Ion Homeostasis of Oral Streptococci

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


PHR: Project Narrative – Career Enhancement Program The Wistar/UPenn SPORE in Skin Cancer Career Enhancement Program (CEP) will prepare the next generation of translational investigators in skin cancer. We will recruit and support a diverse pool of exceptional early-career investigators who are committed to establishing an independent translational research program in skin cancer.

PI_NAMEs: VILLANUEVA, JESSIE  (contact)

PROJECT_TERMS: Acral Lentiginous Malignant Melanoma;Address;anti-cancer research;Awareness;Basal Cell Cancer;cancer cell;Cancer Center;Cancer Research Project;cancer subtypes;career;career development;Career Mobility;Clinical;Department chair;Development;diversity and inclusion;Ensure;expectation;Faculty;Financial Support;Fostering;Foundations;Funding;Funding Agency;Future;Goals;Grant;health disparity;high standard;innovation;interest;investigator training;Laboratories;Leadership;Malignant Squamous Cell Neoplasm;Measures;meetings;Melanoma;member;Mentors;Mentorship;Minority;Monitor;next generation;Oral;Outcome;Paper;Peer Review;Pennsylvania;Policies;Positioning Attribute;Procedures;programs;Progress Reports;Publications;Publishing;Qualifying;recruit;Research;research and development;Research Personnel;Research Project Grants;Resources;Skin Cancer;Solid;success;Talents;The Wistar Institute;Training;translational cancer research;Translational Research;translational research program;translational scientist;Underrepresented Minority;Universities;Woman;Work;Writing

PROJECT_TITLE: Career Enhancement Program


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Infectious Diseases;Lung;Patient Safety;Pediatric

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it directly addresses a growing need to understand how best to deimplement entrenched practices that are not supported by the best available evidence because they are unnecessary, costly, and do not improve patient outcomes. Advancing the science of de- implementation is directly relevant to NIH’s goal to foster innovative research strategies and their applications as a basis for ultimately protecting and improving health. This project is also aligned with NHLBI Strategic Vision Objective #6, Optimize clinical and implementation research to improve health and reduce disease.

PI_NAMEs: BEIDAS, RINAD SARY;BONAFIDE, CHRISTOPHER PETER (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Academy;Acute;acute bronchiolitis;Address;Admission activity;Air;American;Area;arm;Bronchiolitis;Caring;Categories;Child;Childhood;Clinical;Clinical Pathways;Clinical Research;cluster randomized design;cost;Deimplementation;design;Disease;Education;Education and Outreach;Effectiveness;Electronic Health Record;Experimental Designs;Fatigue;Feedback;Fostering;Funding;Goals;Guidelines;Health;health care delivery;Health Sciences;Healthcare;Healthcare Systems;Hospital Charges;Hospitalization;Hospitals;Hybrids;implementation research;improved;Incidence;Infant;Infectious Lung Disorder;innovation;Inpatients;insight;Institutionalization;Intervention;Interview;Length of Stay;Link;Lung Diseases;Maps;Measurement;Medical;Methods;Monitor;National Heart, Lung, and Blood Institute;Observational Study;Outcome;Oxygen;Pathway interactions;Patient Monitoring;patient safety;Patient-Focused Outcomes;Patients;Pediatric Research;Pediatrics;Penetration;Phase;pilot trial;Population;Practice Guidelines;primary outcome;Process;Public Health;Pulse Oximetry;Research;Research Personnel;Risk;Science;secondary outcome;Strategic vision;success;supplemental oxygen;System;Testing;United States;United States National Institutes of Health;Viral Bronchiolitis;Viral Respiratory Tract Infection;wasting

PROJECT_TITLE: Eliminating Monitor Overuse (EMO) Hybrid Effectiveness-Deimplementation Trial


ORG_CITY: EAST LANSING

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Mislocalized and aggregated tail-anchored (TA) proteins have been linked to various human diseases such as diabetes, cancer, neurodegenerative and congenital heart diseases. The main goal of this proposal is to investigate how cells ensure efficiency and fidelity of TA-targeting to the endoplasmic-reticulum membrane. Understanding this process in molecular detail can potentially lead to novel therapeutic strategies to fight various diseases caused by defects in TA biogenesis.

PI_NAMEs: KIM, HYOJIN (KELLY)  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Apoptosis;Binding;Biogenesis;Cell Physiology;Cells;Complex;congenital heart abnormality;Cryoelectron Microscopy;Defect;Diabetes Mellitus;Disease;Endoplasmic Reticulum;Ensure;Event;fighting;Goals;human disease;insight;interdisciplinary approach;Knowledge;Link;Lipid Bilayers;Malignant Neoplasms;Membrane;Membrane Proteins;Molecular;Nerve Degeneration;novel therapeutic intervention;Pathway interactions;Process;protein complex;protein function;protein protein interaction;Proteins;Quality Control;Regulation;Tail;vesicle transport;Visualization

PROJECT_TITLE: Mechanistic Understanding of Post-Translational Membrane Protein Targeting

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Pediatric

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: The proposed research examines the neurocognitive bases of treatment response to evidence-based  learning programs for reading remediation. We use pre and post treatment neuroimaging and frequent  neuroimaging during the course of treatment 1) to gain new insights into how treatment modulates brain organization for literacy, language learning, and remediation; 2) why it fails todo so for some children, and 3) what might constitute a more beneficial focus in minimal-responders. The proposed research represents a  key step towards the development of comprehensive and mechanistic models of the neural underpinnings of  typical and atypical reading development. Project Narrative

PI_NAMEs: PUGH, KENNETH R. (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: adaptive learning;Aftercare;base;Behavior;behavior change;behavioral outcome;Brain;Brain region;Child;cohort;design;Development;Disabled Children;Educational Technology;Electroencephalography;evidence base;experimental study;Functional Magnetic Resonance Imaging;functional near infrared spectroscopy;Goals;Grain;Grant;Growth;Individual Differences;insight;Instruction;Intervention;Language Development;Learning;literacy;Monitor;Morphology;multimodal neuroimaging;neural;neural model;neurobiological mechanism;Neurocognitive;neuroimaging;novel;Orthography;Phase;phonology;Prediction of Response to Therapy;Printing;Process;programs;Qualifying;Reading;Reading Disabilities;remediation;Research;response;Schools;Speech;Standardization;Testing;Training;Treatment Factor;Treatment outcome;treatment response;Variant

PROJECT_TITLE: Tracking neurocognitive changes during evidence-based reading instruction in typically and atypically developing children

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Hypertension;Kidney Disease;Nutrition

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Proposed studies address the role of paraoxonase 3 in regulating key proteins in the distal aspects of kidney nephrons that transport sodium and potassium. Dysregulation of these transporters leads to abnormal volume and blood pressure, and abnormal blood levels of potassium. This work has the potential to uncover mechanisms by which paraoxonase 3 regulates specific kidney transporters and identifies a target for novel therapeutics to treat hypertension and hyperkalemia.

PI_NAMEs: SHI, SHUJIE  (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: absorption;Address;Affect;Aldosterone;Amiloride;Apical;aryldialkylphosphatase;Arylesterase;Biological Models;Biotinylation;Blood;Blood Pressure;blood pressure control;blood pressure regulation;Caenorhabditis elegans;Cell Line;cell type;Cells;Data;Diet;Dietary Potassium;dietary salt;differential expression;Distal;Distal convoluted renal tubule structure;driving force;Duct (organ) structure;Endoplasmic Reticulum;epithelial Na+ channel;extracellular;Extracellular Fluid;Family;Genetic Transcription;Homeostasis;hyperkalemia;Hypertension;Hypokalemia;Hypotensives;Immunofluorescence Immunologic;in vivo;Intake;Intercalated Cell;Ion Channel;Kidney;Knockout Mice;large-conductance calcium-activated potassium channels;Measures;Mediating;member;Metabolic;Molecular Chaperones;Monitor;multicatalytic endopeptidase complex;Mus;Natriuresis;Nephrons;Neurons;new therapeutic target;novel;Patch-Clamp Techniques;Pathway interactions;Pattern;Phosphorylation;Physiological;Potassium;Potassium Channel;Property;Proteins;Publishing;Radio;Rattus;receptor;Regional Perfusion;Regulation;Renal function;Role;Side;SLC12A3 gene;Sodium;Sodium Chloride;Stains;Substrate Specificity;Surface;symporter;Telemetry;Tissues;Touch sensation;Ubiquitination;Water;Western Blotting;Work

PROJECT_TITLE: Role of PON3 in regulating renal Na+ and K+ homeostasis

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Hematology;Immunotherapy;Orphan Drug;Prevention;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Novel Biologic Therapies for GVHD Narrative: Every year, thousands of patients undergo hematopoietic stem cell transplant. While this procedure is potentially lifesaving for patients with hematologic malignancies and non-malignant hematologic disease, it is still plagued with complications. Of these complications, severe GI acute graft versus host disease (AGVHD) represents the major cause of early morbidity and mortality. The proposed research is highly relevant to public health because it aims to improve clinical outcomes for patients that are undergoing hematopoietic stem cell transplantation, by discovering new strategies to prevent and treat severe GI AGVHD.

PI_NAMEs: KEAN, LESLIE S (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Acute Graft Versus Host Disease;Address;Antibodies;antiviral immunity;aurora kinase;Automobile Driving;Back;Biological Response Modifier Therapy;Biopsy;Blood;Calcineurin inhibitor;Categories;CD28 gene;CD34 gene;CD80 gene;Cell Therapy;Cell Transplantation;Cessation of life;Clinic;Clinical;clinical candidate;clinical translation;Clinical Trials;cohort;Cyclophosphamide;cytokine;design;Development;Disease;disease diagnosis;disease model;disorder prevention;Dose;effector T cell;Eragrostis;Evaluation;evidence base;Gastrointestinal tract structure;Goals;graft vs host disease;graft vs leukemia effect;Hematologic Neoplasms;Hematological Disease;Hematopoietic Stem Cell Transplantation;high risk;Human;Immune;Immunity;Immunology;Immunosuppression;Impact evaluation;improved;in vivo;Infection;infection risk;Infiltration;Inflammation;Inflammatory Bowel Diseases;inhibitor;Interferons;isoimmunity;Life;Ligands;Link;Malignant - descriptor;Metabolism;Methotrexate;migration;Modeling;Molecular;Monoclonal Antibodies;Morbidity - disease rate;mortality;Multicenter Trials;multiple omics;Mus;new therapeutic target;next generation;Non-Malignant;nonhuman primate;notch protein;novel;novel therapeutics;Pathogenesis;Patient Care;Patient-Focused Outcomes;Patients;personalized diagnostics;Positioning Attribute;post-transplant;pre-clinical;preservation;prevent;Prevention strategy;Procedures;Prophylactic treatment;Public Health;Refractory;Refractory Disease;Regimen;Regulatory T-Lymphocyte;Relapse;Research;Residencies;Resistance;response;Risk;Sampling;Signal Transduction;single-cell RNA sequencing;Stains;Steroids;System;T cell infiltration;targeted treatment;Techniques;Testing;Therapeutic;therapeutic candidate;therapy development;Tissues;TNFSF4 gene;Toxic effect;trafficking;transcriptome;Translating;translational pipeline;Transplant Recipients;treatment strategy;tumor;Viral

PROJECT_TITLE: Novel Biologic Therapies for GVHD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-H(02)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: MORGANTOWN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: The Biomedical Summer Institute at West Virginia University (WVU) for teachers, mentors, and students directed by Health Sciences and Technology Academy (HSTA) leadership and staff in collaboration with university faculty sets the foundation for the HSTA academic year community-based after school clubs during which specially trained HSTA teachers mentor students into research. Through the after-school club curriculum HSTA students will use validated resources, supported by HSTA TEAMS of mentors, to design science, technology, engineering, mathematics, and medicine (STEM+M) educational interventions or experiments with middle school students. The results of the STEM+M community-based research projects will be disseminated through regional and state HSTA research symposiums, as well as through national conferences and publications.

PI_NAMEs: MORTON, MARY CATHERINE (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Academy;Address;Adolescent;Award;Bachelor's Degree;Back;Basic Science;behavior change;behavioral health;Brain;citizen science;Clinical;cohort;Collaborations;college;Communities;community based participatory research;community based research;Community Health;Complement;County;Data;Degree program;design;Development;Educational Curriculum;Educational Intervention;Educational process of instructing;Educational Status;Educational workshop;Ensure;Epidemiology;experience;experimental study;Faculty;Family;flexibility;Foundations;Goals;Graduate Degree;graduate student;Health;Health Sciences;Health Technology;health training;high school;High School Faculty;High School Student;improved;innovation;Knowledge;Lead;Leadership;Learning;Link;meetings;Mentors;Mentorship;Middle School Faculty;Middle School Student;Neurosciences;novel strategies;peer coaching;Preparation;Problem Solving;Process;programs;Public Health;Publications;Research;Research Design;Research Project Grants;Research Support;Resources;Schools;Science;science education;science, technology, engineering, mathematics, and medicine;social media;Structure;student mentoring;Students;summer institute;symposium;teacher;teacher mentor;Teacher Professional Development;theories;Thinking;Time;tool;Training;undergraduate student;United States National Institutes of Health;Universities;web site;West Virginia;Work

PROJECT_TITLE: HSTA TEAMS for Community Health: Teaching Educators and Adolescents Mentoring and Science (TEAMS) to Improve Community Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Hematology;Pediatric

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE Critically ill children supported by extracorporeal membrane oxygenation (ECMO) receive large volumes of prophylactic platelet transfusions to prevent bleeding, although mounting evidence has demonstrated significant morbidity and mortality associated with these transfusions. The ECmo hemoSTAtic Transfusions In Children (ECSTATIC) pilot trial will test two different platelet transfusion strategies, based on two different platelet counts thresholds, one high (liberal strategy) and one low (restrictive strategy). The pilot will gather the necessary information to perform a full trial which will provide a better understanding of how to transfuse platelets to children supported by ECMO and reduce the associated morbidity.

PI_NAMEs: KARAM, OLIVER L (contact);NELLIS, MARIANNE

PROGRAM_OFFICER_NAME: HUANG, WEN-CHUN AMY

PROJECT_TERMS: 18 year old;adjudication;arm;Benefits and Risks;Blinded;Blood Coagulation Disorders;Blood Platelets;Cannulations;Child;Child Support;Childhood;Clinical;Clinical Trials;Coagulation Process;cohort;Consent;Critically ill children;Data;design;Enrollment;Equilibrium;Etiology;Expert Opinion;Extracorporeal Membrane Oxygenation;Frequencies;Future;Goals;Guidelines;Hemodilution;Hemorrhage;Hemostatic Agents;improved outcome;Infant;Inflammatory;information gathering;Informed Consent;innovation;Life;manufacture;Methods;Morbidity - disease rate;mortality;Nature;Observational Study;open label;Outcome;participant enrollment;patient population;Patients;Pediatric Acute Lung Injury;pediatric patients;Pilot Projects;pilot trial;Platelet Count measurement;Platelet Transfusion;Population;Premature Infant;prevent;Process;programs;prophylactic;Publishing;Randomized;randomized controlled design;Randomized, Controlled Trials;Reporting;Research Personnel;Risk;Running;Sepsis;Severities;Site;Testing;Thrombocytopenia;Thrombosis;thrombotic;thrombotic complications;Transfusion;treatment arm

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(MA)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Data Science;Hematology;Networking and Information Technology R&D (NITRD);Skin Cancer;Urologic Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: WISTAR INSTITUTE

PHR: Project Narrative The application is aimed to support cancer-related research efforts of The Wistar Institute investigators through computational expertise provided by Bioinformatics Shared Resource. Focus of the supported projects involve experiments designed to understand basic mechanisms of cancers, including melanoma, ovarian, prostate, various blood cancers, lung, colon and many others with the final goal of developing methods for cancer prevention, diagnosis and treatment.

PI_NAMEs: KOSSENKOV, ANDREW V (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Award;Bioinformatics;Bioinformatics Shared Resource;Cancer Center;Cancer Center Support Grant;cancer prevention;Collaborations;Colon;Computational Biology;Computing Methodologies;Data;data analysis pipeline;Data Set;Databases;Diagnosis;Elements;Environment;Experimental Designs;Goals;Hematopoietic Neoplasms;high throughput analysis;knowledgebase;Lung;Malignant Neoplasms;Melanoma;member;Methods;Ovarian;programs;Prostate;Research;Research Personnel;Research Project Grants;Resources;Role;The Wistar Institute

PROJECT_TITLE: Integrative Approach to Comprehensive Analysis of High Throughput Data on a Cancer Center Level


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PUBLIC HEALTH RELEVANCE Our research aims to understand how bacterial pathogens use chemical signals to sense and adapt to the host. In this proposal, we will develop biosensor technologies that light up these chemical signals and allow us to track them in different bacteria, including pathogens that cause cholera, typhoid fever, urinary tract infections, and food poisoning.

PI_NAMEs: HAMMOND, MING CHEN (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Affect;Animal Model;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Bacteria;Behavior;Binding;Bioinformatics;Biological Assay;Biology;Biosensor;Cell Culture Techniques;Cell Physiology;Cells;cellular imaging;Charge;Chemicals;Cholera;Clinical;Combating Antibiotic Resistant Bacteria;Complex;Cytometry;Development;Diet;Drug Compounding;Drug Design;Dyes;Electron Microscopy;Environment;Environmental Risk Factor;enzyme activity;Enzymes;Flow Cytometry;Fluorescent Dyes;Food Poisoning;Foundations;Funding;Gene Expression;Genes;Genetic;genetic analysis;Goals;Gram-Negative Bacteria;Growth;gut colonization;gut health;gut microbiota;Health;Health Status;high throughput analysis;high throughput screening;Human;Image;improved;in situ imaging;Inflammatory Bowel Diseases;insight;invention;Light;Link;Mammalian Cell;Measures;Messenger RNA;Methods;Microbial Biofilms;Microbiology;Modeling;Molecular Genetics;molecular imaging;Molecular Structure;Monitor;Motility;next generation;Noise;novel;Nutrient;Organism;Outcome;pathogen;pathogenic bacteria;Pathway interactions;Periodicity;Permeability;Phase;Physiological;prebiotics;Process;Production;Productivity;programs;Property;public health relevance;ratiometric;real time monitoring;Regulation;Regulatory Pathway;Research;RNA;screening;Signal Transduction;Signaling Molecule;small molecule;Speed;Structure;Structure-Activity Relationship;Surface;Technology;Time;tool;Toxin;Typhoid Fever;uptake;Urinary tract infection;Visualization

PROJECT_TITLE: Enabling High-Throughput Analysis and Single-Cell Imaging of Bacterial Signals

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Orphan Drug;Prevention;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative There is an extreme unmet for drugs that can prevent oral cancer in high risk patients. This clinical trial will test a combination drug, pioglitazone-metformin, in patients at high risk for developing mouth cancer. The findings from this trial can ultimately result in a treatment that would be available for use in over 250,000 patients a year who are at high risk for oral cancer development or recurrences.

PI_NAMEs: ONDREY, FRANK G. (contact)

PROGRAM_OFFICER_NAME: WOJTOWICZ, MALGORZATA E

PROJECT_TERMS: Affect;Aftercare;Animal Model;antagonist;anti-cancer;Anti-diabetic Drugs;Apoptosis;Biguanides;Cancer Patient;cancer prevention;cancer survival;carcinogenesis;Carcinoma;CASP3 gene;CD8B1 gene;Cell Differentiation process;Cell Line;Chemoprevention;Chemopreventive Agent;Clinic;Clinical;Clinical Chemoprevention;Clinical Trials;cohort;Combined Modality Therapy;Data;Development;Dose;Drug Combinations;Epigallocatechin Gallate;Event;experience;Fortification;FRAP1 gene;Funding;Gene Expression;Head and Neck Cancer;Healthcare;high risk;Histologic;Human;improved;indexing;Individual;Inflammation;Inflammatory;Intervention;Lesion;Leukoplakia;Link;malignant mouth neoplasm;Malignant Neoplasms;Metformin;Mucous Membrane;Neoplasms;NF-kappa B;non-diabetic;Nuclear;Oral;oral cancer prevention;oral carcinogenesis;Oral cavity;Oral Leukoplakia;oral premalignancy;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacodynamic biomarker;Pharmacodynamics;Phase;Phase I Clinical Trials;Physiological;PIK3CG gene;Pioglitazone;Population;PPAR gamma;Precancerous Conditions;premalignant;prevent;prevention clinical trial;Prevention strategy;Prevention trial;preventive intervention;programmed cell death ligand 1;programmed cell death protein 1;Prostaglandin-Endoperoxide Synthase;randomized trial;Recurrence;Research;response;Risk;Safety;Series;Signal Transduction;Specimen;Stains;stemness;T-Lymphocyte Subsets;Testing;Thiazolidinediones;Tobacco;Tobacco-Associated Carcinogen;Toxic effect;transcriptome sequencing;Tretinoin;Work

PROJECT_TITLE: Pioglitazone-Metformin Combination Treatment for High Risk Oral Preneoplasia

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE PREVENTABLE will evaluate the benefit and risks of moderate-intensity statin for preventing dementia and prolonging disability-free survival in a diverse population of patients 75 years and older without heart disease. We will also evaluate the benefit and risks of moderate-intensity statin use in reducing a cardiovascular outcome (myocardial infarction/acute coronary syndrome hospitalizations, stroke, heart failure, or cardiovascular-related death) or mild cognitive impairment or dementia, and collect lab specimens on 17,000 participants to advance precision health.

PI_NAMEs: ALEXANDER, KAREN P (contact);AMBROSIUS, WALTER T;HERNANDEZ, ADRIAN ;WILLIAMSON, JEFF DOUGLAS

PROGRAM_OFFICER_NAME: SAZONOVA, IRINA Y

PROJECT_TERMS: acute coronary syndrome;Alzheimer's disease related dementia;Alzheimer's disease risk;Ancillary Study;Benefits and Risks;biobank;Biochemical;blood pressure intervention;Blood Vessels;Capsicum;Cardiology;cardiovascular risk factor;Cardiovascular system;Caring;Cessation of life;Classification;Clinical;clinical care;Clinical Research;Clinical Trials;Clinical Trials Design;Cognitive;collaboratory;comorbidity;Comparative Study;Coronary heart disease;Data;Data Science;Dementia;design;Detection;Diabetes Mellitus;disability;Disability outcome;Disability prevention;Effectiveness;Elderly;Equipoise;Ethnic Origin;Evaluation;Event;evidence base;Exclusion;experience;frailty;functional outcomes;Funding;Future;Genomics;Geriatrics;Ginkgo biloba;Goals;Health;Health Status;Healthcare Systems;Heart Diseases;Heart failure;Heterogeneity;High Prevalence;Hospitalization;human subject;Hyperlipidemia;Image;Impaired cognition;improved;Information Dissemination;Infrastructure;insight;International;Intervention Trial;Knowledge;Lead;Leadership;Life Expectancy;Lipids;Medical;medical schools;Memory;Methodology;Methods;mild cognitive impairment;multiple chronic conditions;Muscle;Myocardial Infarction;older adult;Older Population;Outcome;Participant;patient population;Patients;Pharmaceutical Preparations;Physical Function;physical impairment;Placebo Control;Polypharmacy;Population;Population Heterogeneity;Pragmatic clinical trial;pragmatic trial;Precision Health;preservation;prevent;Prevention;primary outcome;Primary Prevention;racial diversity;recruit;Recurrence;Reporting;revascularization;Risk;Role;Safety;safety testing;Specimen;Stroke;Subgroup;success;survival outcome;Symptoms;systems research;United States National Institutes of Health;Vascular Cognitive Impairment;Veterans Health Administration

PROJECT_TITLE: PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr Adults (PREVENTABLE)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Disability Research;Neurodegenerative

PI_NAMEs: ALEXANDER, KAREN P (contact)

PROJECT_TERMS: adjudication;Advocate;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;biobank;Biological Markers;Boston;Budgets;Clinic;Clinical;Clinical and Translational Science Awards;Clinical Research;Clinical Trials;Clinical Trials Design;cognitive function;cognitive testing;Collaborations;collaboratory;Communication;Computerized Medical Record;cooperative study;Coronary heart disease;Data;Data Coordinating Center;data integration;data quality;Dementia;disability;Disability Evaluation;Doctor of Philosophy;electronic consent;Electronic Health Record;Ensure;Evaluation;Event;experience;frailty;Health;Healthcare Systems;Individual;innovation;Institutional Review Boards;International;Intervention;Leadership;Life;Life Cycle Stages;Lipids;medical schools;mild cognitive impairment;Monitor;Multi-Institutional Clinical Trial;Multicenter Trials;multiple chronic conditions;National Heart, Lung, and Blood Institute;National Institute of Neurological Disorders and Stroke;National Institute on Aging;Occupational activity of managing finances;older adult;Outcome;Participant;patient oriented;Patients;Pharmaceutical Preparations;Pharmacy facility;Physical Function;physical impairment;Polypharmacy;Populations at Risk;pragmatic trial;prevent;programs;Protocols documentation;Recording of previous events;recruit;Reporting;Research;Research Institute;Resources;Risk;Role;Schedule;Site;Societies;statistical service;Structure;United States National Institutes of Health

PROJECT_TITLE: PREVENTABLE Administrative and Trial Management


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Disability Research;Heart Disease;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety;Prevention

PI_NAMEs: HAMMILL, BRADLEY G (contact)

PROJECT_TERMS: acronyms;acute stroke;Adherence;adjudication;Alzheimer's Disease;Aspirin;atorvastatin;biobank;Biometry;Blinded;blood pressure intervention;Cardiovascular Diseases;cardiovascular risk factor;Clinic;Clinical;Clinical and Translational Science Awards;clinical center;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Data Monitoring Committees;Cognitive;Collaborations;Communication;Consensus;Contracts;cooperative study;Coronary heart disease;cost;Data;Data Analyses;Data Coordinating Center;data management;Data Management Resources;data modeling;Databases;Dedications;Dementia;design;Development;Diabetes Mellitus;disability;Disability outcome;Dose;Double-Blind Method;drug distribution;Effectiveness;EHR research;Elderly;Electronic Health Record;Ensure;Environment;epidemiology study;Evaluation;Event;experience;follow-up;frailty;Geriatrics;Health;Inflammation;Information Centers;innovation;International;Internet;Intervention;Intervention Trial;lifestyle intervention;Lipids;Maintenance;Manuals;Massachusetts;Measurement;medical schools;member;Memory;Methodology;mild cognitive impairment;Modeling;Monitor;mortality;Multicenter Trials;multiple chronic conditions;Network Infrastructure;older adult;Online Systems;operation;Outcome;Outcome Study;Participant;participant safety;patient oriented;Patient Recruitments;Patients;Pharmaceutical Preparations;Pharmacy facility;Physical Function;physical impairment;Placebos;Polypharmacy;Populations at Risk;Pragmatic clinical trial;prevent;Procedures;Process;Productivity;programs;protocol development;Protocols documentation;Publications;quality assurance;Randomized;randomized, clinical trials;Recording of previous events;recruit;Reporting;Research Design;Research Institute;Research Personnel;Role;Safety;Security;Services;Site;skills;sound;Specific qualifier value;Standardization;Statistical Data Interpretation;Stress;success;System;Testing;tool;Training;United States Department of Veterans Affairs;Universities;Veterans;virtual;Visit;website development

PROJECT_TITLE: PREVENTABLE Data Coordinating Center


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Lung

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE There remains an urgent unmet need to improve our understanding of the physiological mechanisms of pulmonary injury following exposure to understudied highly toxic chemicals. This proposal will address this unmet need by characterizing dose/toxicity relationships for a broad range of highly toxic chemicals with an in vitro airway-on-a-chip model and performing analysis of the fundamental molecular, cellular, and physiological pathways involved in toxicity/pathology.

PI_NAMEs: MURPHY, SEAN VINCENT (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: 3-Dimensional;Acceleration;Acids;Acute;African American population;Alkylating Agents;Area;authority;Biochemical;Bioinformatics;bioinformatics pipeline;Biological;Biological Assay;Bulla;Caucasians;Cell Respiration;Cells;Chemical Exposure;chemical threat;Chemical Weapons;Chemically Induced Toxicity;Chemicals;chlorine gas;Cilia;Country;Databases;Development;differential expression;Docking;Dose;Ethnic Origin;Evaluation;Event;Exposure to;FDA approved;Female;Frequencies;Funding;Future;Gases;Genes;Health;Hispanic Populations;Hour;Human;improved;in silico;In Vitro;Industrialization;Inflammatory;inhibitor;Injury;innovation;Intervention;Lethal Dose 50;Liquid substance;Lung;lung injury;male;manufacturing scale-up;mass casualty;Measures;Mediator;medical countermeasure;metabolic poison;Military Personnel;Modeling;Molecular;Molecular Target;multiple omics;Nebulizer;novel;Nuclear;Ontology;Organ;Oxidative Stress;Pathogenicity;Pathology;Pathway interactions;Pesticides;Physiological;Poison;Population;Probability;Procedures;programs;Public Health;racial diversity;Radiology Specialty;rapid test;research and development;response;Risk;Safety;Security;Signal Transduction;Surface;System;Testing;Tissues;Toxic effect;Toxicokinetics;transcriptome;transcriptomics;Validation;vapor;Vesicants;Work

PROJECT_TITLE: Characterizing chemical threat agent exposures using a lung-on-a-chip platform and multi-omic analysis of common pathophysiological mechanisms


NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Lung;Palliative Care;Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention;Primary Health Care

PHR: Project narrative Although the majority of patients with chronic obstructive pulmonary disease (COPD) take fall-risk increasing drugs (FRIDs) and falls are a significant source of morbidity and mortality for patients, there are to date no interventions that tailor and target deprescribing efforts for this population. This K23 application will adapt and test a novel pharmacist-led deprescribing intervention for patients with COPD, using qualitative data from patients, family caregivers and prescribers to guide the adaptation, delivery, and evaluation of a pharmacist-led deprescribing intervention. This research will provide data on how to reduce medication-related harm to improve quality of life and reduce medication-associated morbidity and mortality for patients with COPD.

PI_NAMEs: MCDERMOTT, CARA LYN (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Academic Medical Centers;Address;Adult;anxiety symptoms;Award;Behavior Therapy;behavioral clinical trial;Behavioral trial;Benzodiazepines;career;Caregivers;Caring;Cessation of life;Chronic Obstructive Pulmonary Disease;Clinic;Clinical;Clinical Trials;Clinical Trials Design;Communication;Communities;comparative efficacy;cost;Data;Databases;Dedications;Drug Combinations;Drug usage;effectiveness/implementation trial;Emergency department visit;Evaluation;Evidence based intervention;fall injury;fall risk;falls;Family Caregiver;frailty;functional status;Funding;Future;Goals;Health;health care delivery;Healthcare;high risk;Hospitalization;Hospitals;hypnotic;implementation science;improved;Incidence;Individual;individual patient;Injury;innovation;Intervention;intervention participants;Intervention Trial;Interview;Knowledge;Learning;Lung;Managed Care;Measures;medical specialties;Medication Management;medication safety;Morbidity - disease rate;mortality;Muscle relaxants;National Heart, Lung, and Blood Institute;novel;Opioid;Outcome;Outpatients;Oxygen;Pain;Participant;patient oriented;patient population;patient safety;Patients;Pharmaceutical Preparations;Pharmacists;pilot trial;Polypharmacy;Population;Primary Care;primary care clinic;primary care provider;primary outcome;programs;provider communication;Quality of life;Questionnaires;randomized trial;Recording of previous events;Reporting;Research;Risk;Risk Assessment;safety net;Scientist;sedative;shared decision making;Sleeplessness;Source;Statistical Methods;Structure;symptom treatment;Symptoms;Testing;Therapeutic;Training;treatment as usual;Treatment Efficacy;Tricyclic Antidepressive Agents;Tube;Visit;Withdrawal;Work

PROJECT_TITLE: Reducing Polypharmacy and Fall Risk for Multi-Morbid Adults with Chronic Obstructive Pulmonary Disease

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Patient Safety;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: JONES, WILLIAM S (contact)

PROJECT_TERMS: Address;Adverse effects;Age;Alzheimer's Disease;Area;Arthralgia;Aspirin;Australia;Behavioral;Cardiovascular system;Caring;Clinical;clinical trial recruitment;Clinical Trials;Communication;Communities;community engaged approach;comorbidity;Competence;Consent;Consent Forms;Coronary heart disease;Data;Decision Making;Dementia;Development;disability;Dose;Effectiveness;Elderly;Electronic Health Record;Enrollment;Ensure;ethnic minority;ethnic minority population;Evaluation;Event;experience;Fall prevention;Family member;Feedback;frailty;Geographic Locations;Healthcare;Healthcare Systems;Hemorrhage;Impaired cognition;Incentives;informatics tool;Informed Consent;Infrastructure;innovation;Leadership;Lipids;Methods;mild cognitive impairment;Minority Recruitment;mortality;Multicenter Trials;multiple chronic conditions;Myalgia;older adult;older patient;Older Population;Outcome;Participant;participant retention;patient engagement;Patients;Persons;Pharmaceutical Preparations;Physical Function;physical impairment;Polypharmacy;Population;preference;prevent;primary care clinician;primary care provider;primary outcome;Primary Prevention;Process;protocol development;Protocols documentation;Quality of life;racial minority;racial minority population;Randomized;Reading;recruit;Reporting;Research;Research Design;Research Personnel;Resources;retention rate;Risk;Role;screening;secondary outcome;Services;Site;social;Testing;tool;Transportation;United States;United States Department of Veterans Affairs;Universities;Veterans Health Administration;Visit;Woman

PROJECT_TITLE: PREVENTABLE Recruitment and Retention


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Precision Medicine

PI_NAMEs: NEWBY, LAURA KRISTIN (contact)

PROJECT_TERMS: Adverse effects;Aging;aging mechanism;All of Us Research Program;Alzheimer's Disease;Ancillary Study;biobank;Biological;Biological Markers;Biological Specimen Banks;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Child Health;Clinic;Clinical;Cognitive;cohort;Collaborations;Collection;Communication;Communities;Coronary heart disease;Dementia;design;Development;disability;Disease;Disease Progression;Ensure;Evaluation;Event;experience;follow-up;frailty;Funding;Future;Geroscience;Goals;Health;healthy aging;Impaired cognition;individualized medicine;inflammatory marker;Infrastructure;insight;International;Laboratories;Leadership;Libraries;Lipids;Longevity;medication compliance;mild cognitive impairment;Molecular;multiple chronic conditions;older adult;operation;Outcome;Participant;Patients;Persons;Physical Function;physical impairment;Physiological;Policies;Polypharmacy;Positioning Attribute;precision medicine;prevent;Procedures;Process;programs;protocol development;Protocols documentation;Quality Control;Randomized;randomized trial;randomized, clinical trials;Registries;Research;Research Personnel;Resources;Retrieval;Risk;Role;Sampling;Science;Specific qualifier value;Subgroup;Testing;treatment effect;Treatment Efficacy;United States National Institutes of Health;working group

PROJECT_TITLE: PREVENTABLE Biorepository and Laboratory


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

ORG_STATE: CA

PHR: Project Narrative WormBase is an international consortium of biologists and computer scientists providing the research community with accurate, current, accessible information concerning the genetics, genomics and biology of C. elegans and related nematodes. Using a combination of expert curation, machine learning, and AI-enhanced community curation, we will integrate information about the C. elegans genome and sequence features, gene function, expression and interaction, and human disease models. We will transition to using the software infrastructure of the Alliance of Genome Resources for sustainability and economies of scale.

PI_NAMEs: DYER, SARAH ;SCHEDL, TIM ;STEIN, LINCOLN D.;STERNBERG, PAUL WARREN (contact)

PROGRAM_OFFICER_NAME: XIRASAGAR, SANDHYA

PROJECT_TERMS: Address;Anatomy;Antibodies;Artificial Intelligence;Artificial Intelligence enhanced;Automation;Base Sequence;bioinformatics resource;Biological Assay;Biology;C. elegans genome;Caenorhabditis elegans;Communities;computer infrastructure;computer scientist;Computer software;Data;Data Collection;data infrastructure;data ingestion;data modeling;data resource;Data Set;Data Storage and Retrieval;Development;disease model;DNA;experimental study;Gene Expression;gene function;gene interaction;Gene Structure;Generations;Genes;Genetic;Genome;genome annotation;genome editing;genome resource;genome-wide;Genomics;human disease;Incentives;Individual;Information Centers;information display;Infrastructure;infrastructure development;International;knowledgebase;Laboratories;Literature;Machine Learning;migration;Modeling;Nematoda;Neuroanatomy;Nomenclature;Nucleic Acid Regulatory Sequences;Ontology;Organism;Pathway interactions;Phenotype;Publishing;Quality Control;Reagent;Reporter Genes;Research;Research Personnel;Resources;single-cell RNA sequencing;Site;software infrastructure;Specific qualifier value;sustainable resource;System;Time;tool;Training;transcriptome sequencing;transcriptomics;Transgenic Organisms;Variant;web portal;WormBase

PROJECT_TITLE: WormBase: a core data resource for C. elegans and other nematodes


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

PHR: Project Narrative Developing new methods for accurately capturing dietary intake is crucial for revealing true associations between diet and disease. We propose to apply the newly developed US population-based dietary biomarkers for sugars and protein quality as objective measures of intake to inform the best practices for their use in future diet validation studies and studies of diet-disease associations. Well-established biomarkers of sugars and protein quality are key for revealing the true health effect of sugars and clarifying the potentially differential health effects of animal protein and plant protein intake.

PI_NAMEs: TASEVSKA, NATASHA  (contact)

PROGRAM_OFFICER_NAME: HERRICK, KIRSTEN ANNE

PROJECT_TERMS: aged;Animals;Biological;Biological Markers;Biomarker of Dietary Intake;biomarker performance;burden of illness;Calibration;Carbon Isotopes;Cardiovascular Diseases;cardiovascular disorder risk;Characteristics;Chronic Disease;cohort;Data;Dental caries;diabetes risk;Diet;dietary;Dietary Assessment;Dietary intake;Dietary Sugars;Disease;disorder risk;Energy Intake;epidemiology study;Equation;ethnic diversity;Ethnic Population;Evaluation;evidence based guidelines;feeding;Food;Frequencies;Fructose;Future;Health;health disparity;Hispanic Community Health Study;Hispanic Community Health Study/Study of Latinos;improved;instrument;Intake;Intervention;Investigation;Malignant Neoplasms;Measurement;Measures;Methods;mortality;Nitrogen;Non-Insulin-Dependent Diabetes Mellitus;novel;novel marker;novel strategies;nutritional epidemiology;Nutritional Study;Obesity;Outcome;parent project;Participant;Patient Self-Report;personalized nutrition;Plant Proteins;Play;Population;population based;Population Heterogeneity;Population Study;precision nutrition;predictive marker;Prospective cohort;Prospective, cohort study;protein biomarkers;protein intake;Proteins;Protocols documentation;Questionnaires;racial diversity;Recommendation;Records;Recovery;Resources;Risk;Role;Sampling;Serum;Source;Strategic Planning;Structure;Sucrose;sugar;Testing;Total Sugar;United States National Institutes of Health;urinary;Validation;validation studies

PROJECT_TITLE: Application of predictive biomarkers of sugars and animal protein intake for investigation of dietary measurement error and its effect on diet-disease associations

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Neurodegenerative;Primary Health Care

PI_NAMEs: HERNANDEZ, ADRIAN  (contact)

PROJECT_TERMS: Address;Agreement;Alzheimer's Disease;Award;base;Capsicum;Cardiology;Clinical;Clinical Research;clinical research site;collaboratory;computable phenotypes;Coronary heart disease;Coupled;Data;Data Collection;data modeling;data quality;data sharing;Dementia;disability;Elderly;Electronic Health Record;Eligibility Determination;eligible participant;Enrollment;Ensure;epidemiology study;Evaluation;Event;experience;Family Practice;frailty;Funding;Geographic Locations;Health system;Healthcare Systems;Hospitals;improved;Incentives;Individual;Information Centers;Infrastructure;Institutional Review Boards;interest;Lead;Leadership;Letters;Lipids;Location;Massachusetts;Mediation;Medical center;Medicine;mid-career faculty;mild cognitive impairment;Minority;Monitor;multiple chronic conditions;older adult;Participant;patient engagement;patient oriented;Patients;payment;Performance;performance site;Physical Function;physical impairment;Policies;Polypharmacy;Positioning Attribute;pragmatic trial;prevent;Primary Care;Process;protocol development;Protocols documentation;Puerto Rico;Qualifying;Randomized;recruit;Research;Research Infrastructure;Research Personnel;Resources;Rewards;Role;rural area;Site;skills;Socialization;Standardization;Structure;success;Time;United States Department of Veterans Affairs;United States National Institutes of Health;urban area;Veterans;Woman

PROJECT_TITLE: PREVENTABLE Clinical Sites Core


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: LOS ANGELES

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Patients with end-stage kidney disease (ESKD), who use hemodialysis as their kidney replacement method, require vascular access in the form of an arteriovenous fistula, arteriovenous graft, or central venous catheter to receive life-sustaining hemodialysis. Increasing evidence indicates that outcomes of the different vascular access types vary widely based on patient characteristics, so much so that the recent update of the National Kidney Foundation Dialysis Outcomes Quality Initiative (KDOQI) guidelines states “…there is insufficient evidence for KDOQI to make recommendations on choice of incident vascular access type,” leaving providers and patients to select a vascular access type without adequate evidence of likely outcomes. To overcome this key barrier, the goal of this R01 proposal is to optimize the patient experience of vascular access decision- making by a) developing an interactive, evidence-based guide to vascular access outcomes that incorporates a prognostic model for short and long-term outcomes of vascular access and b) identifying best practices for utilization of the guide during the clinician-patient encounter.

PI_NAMEs: WOO, KAREN  (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: adverse outcome;Age;Anatomy;Arteriovenous fistula;arteriovenous graft;Attitude;Bayesian Network;Blood Vessels;Calibration;Catheters;Characteristics;Client satisfaction;Clinical;cohort;Collaborations;comorbidity;Data;data registry;Data Set;Data Sources;Decision Making;design;Development;Dialysis procedure;Disease Outcome;Disparate;education access;Educational Materials;End stage renal failure;evidence base;experience;Face;Failure;Feedback;Fistula;Foundations;frailty;Goals;Guidelines;Health Services Accessibility;Health system;Hemodialysis;improved;Individual;Information Systems;innovation;Institution;Interview;Kidney;Kidney Diseases;large scale data;Life;Link;Logistic Regressions;machine learning method;Maintenance;Medicare claim;Methods;Modeling;multiple data sources;novel;Obesity;operation;Outcome;outcome prediction;patient engagement;Patient observation;patient response;Patients;Perception;Performance;Peripheral Vascular Diseases;Physicians;Population;preference;Procedures;Process;Prognostic Factor;prognostic model;Provider;provider communication;Qualitative Methods;Race;random forest;Recommendation;Registries;Research;satisfaction;Sensitivity and Specificity;sex;sociodemographics;statistical and machine learning;Structure;Surgeon;Testing;trustworthiness;United States;Update;Venous

PROJECT_TITLE: Improving the patient experience of hemodialysis vascular access decision making

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Disability Research;Health Services;Neurodegenerative;Neurosciences;Patient Safety

PROJECT_TERMS: Adherence;adjudication;Age;Algorithms;Alzheimer's Disease;atorvastatin;Attention;biobank;Cardiovascular system;Cessation of life;Clinical;Clinical Research;Clinical Trials;Cognition;Cognitive;cognitive function;cognitive testing;Collection;Communication;Communities;Coronary heart disease;Data;data exchange;Dementia;design;Development;disability;Disease;Doctor of Philosophy;Elderly;Electronic Health Record;Enrollment;Evaluation;Event;experience;Faculty;Fee-for-Service Plans;Geriatric Assessment;Geriatrics;Gerontology;Hawthorne Effect;Health Status;Health Technology;Heart failure;Hospitalization;Impaired cognition;Impairment;indexing;Institutional Review Boards;International;Intervention;Leadership;Life;Lipids;Manuals;medical schools;Medicare;meetings;member;Monitor;Needs Assessment;Neurocognitive;older adult;operation;Outcome;Outcome Assessment;Participant;participant safety;performance site;Persons;Pharmaceutical Preparations;Phase;Physical Function;Placebos;Population;Positioning Attribute;pragmatic trial;primary outcome;Principal Investigator;Procedures;Process;professor;Protocols documentation;Psychiatry;Quality Control;Randomized;recruit;Reporting;Research;Research Institute;Research Personnel;revascularization;Risk;Role;Safety;safety assessment;secondary outcome;Services;Site;skills;Stroke;success;Testing;Time;tool;Training;United States National Institutes of Health;Validation;Vital Status;Work

PROJECT_TITLE: PREVENTABLE Trial Implementation Phase