NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative The proposed project aims to evaluate changes in treatment (e.g., national guideline-recommended antiretroviral therapy), quality of care, and health outcomes (e.g., healthy days at home, mortality) among an increasingly older population living with HIV (PWH) in the Medicare program. Importantly, the proposed research will also identify the patient-, drug plan-, market-, and community-level factors associated with higher quality of care and improved clinical outcomes among a national, longitudinal cohort of older PWH with age- associated comorbidities (e.g., Alzheimer’s disease and related dementias (ADRD), cardiovascular disease, and mental illness) and of historically marginalized subpopulations with HIV. Finally, this work will be the first national study to evaluate the impact of Medicare value-based alternative payment models (APMs) on older PWH, including Accountable Care Organizations and Bundled Payment Models, which can help inform national public health and policy efforts aimed at improving care for PWH, including consideration of specific policy modifications and carve-outs for PWH under APMs.

PI_NAMEs: FIGUEROA, JOSE FRANCISCO (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: accountable care organization;Acquired Immunodeficiency Syndrome;acute care;Admission activity;Adult;Affect;Age;age related;Age related comorbidities;Aging;Alzheimer's disease related dementia;antiretroviral therapy;Benchmarking;beneficiary;Biological;Black race;bundled payment;Cardiovascular Diseases;care costs;Caring;Chronic;Clinical;Communicable Diseases;Communities;community-level factor;Complex;copayment;cost;Cost Control;Data;Deductibles;design;Disparity;dual eligible;Eligibility Determination;Enrollment;Equity;ethnic minority;Evaluation;experience;Federal Government;financial incentive;frailty;Goals;Government;Guidelines;Health;health care quality;health care service utilization;Health Personnel;Health Services;high risk;HIV;Home;Hospitals;improved;improved outcome;Inequity;Latino Population;Lead;Life Expectancy;Longitudinal cohort;Low income;marginalization;marginalized population;Marketing;medical specialties;Medicare;Medicare/Medicaid;Mental disorders;Modeling;Modification;mortality;multidisciplinary;multiple chronic conditions;novel;older adult;Older Population;Outcome;Patient Care;Patients;payment;Persons;Pharmaceutical Preparations;Policies;Policy Maker;poor health outcome;Population;Predictive Factor;programs;Public Health;Public Policy;Quality of Care;Quasi-experiment;racial minority;Recommendation;Research;Research Design;Research Personnel;Risk;Rural Population;Savings;Services;Silver;social;Specialist;Strategic vision;Subgroup;Time;Tsunami;Work

PROJECT_TITLE: Improving Healthcare Quality and Equity For Older Adults with HIV Under Value-Based Care Models

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: DC

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Pediatric

ORG_CITY: BINGHAMTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_FIPS: US

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

ORG_STATE: NY

PHR: PROJECT NARRATIVE Many children have developmental language disorder, which makes it difficult to learn language, including vocabulary, and results in ongoing academic and social difficulties. Despite the fact that most words are learned in context without direct teaching, we know very little about how children with developmental language disorder learn words in context. This project will combine, for the first time, two strategies which improve contextual word learning in children with typical development, and test their effect in both typically developing children, and those with developmental language disorder. The results will provide timely information that will contribute to evidence based practice for contextual word learning in children with developmental language disorder.

PI_NAMEs: DUFF, DAWNA  (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: 13 year old;8 year old;Achievement;Address;Adult;Age;Awareness;Child;Cognitive;Common Core;Complex;Comprehension;Consumption;design;Development;Disease;Educational Curriculum;Educational process of instructing;effective intervention;Effectiveness;Effectiveness of Interventions;effectiveness testing;evidence base;Evidence based intervention;Evidence based practice;Evidence based treatment;Exposure to;Feedback;first grade;fourth grade;Future;Generations;Goals;Growth;Hearing;improved;innovation;Instruction;Intervention;intervention effect;Knowledge;Language Development;Language Development Disorders;Language Disorders;Learning;Learning Difficulty;lexical;lexical processing;Life;Linguistics;Link;Measures;Memory;Methods;Morphology;Nature;novel;novel strategies;Orthography;Outcome;Participant;phonology;Population;post intervention;Process;programs;Randomized, Controlled Trials;Reading;reading comprehension;Research;Rice;Semantics;skills;social;Students;success;syntax;Testing;Time;Training;treatment effect;Vocabulary;Vocation;word learning;Work

PROJECT_TITLE: Contextual Word Learning in Children with DLD

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Asthma;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Lung;Microbiome;Pediatric;Prevention;Social Determinants of Health;Vaccine Related

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE While it is well-established that severe RSV infection is associated with later childhood asthma, delineating the severity- and age-dependent relationship of RSV infection on asthma risk and lung function is not known and is the focus of this application. The answers to these questions will be critical to developing prevention strategies and informing public health expectations for RSV non-pharmaceutical preventive strategies and evaluating potential long-term value-added benefits of vaccines in preventing lifelong chronic respiratory disease. These data may not only bolster RSV vaccine acceptability and uptake in the US but will almost certainly be useful in evaluating the cost-effectiveness of RSV prevention strategies in low and middle income countries.

PI_NAMEs: HARTERT, TINA V (contact);OSMUNDSON, SARAH SCHEIDERICH

PROGRAM_OFFICER_NAME: ARTEAGA, SONIA S

PROJECT_TERMS: 2 year old;Address;Age;age related;airway epithelium;Asthma;asthma prevention;Biological Process;Biological Specimen Banks;Birth;Black Populations;Bronchiolitis;Child;Child Health;Childhood;Childhood Acute Lymphocytic Leukemia;Childhood Asthma;chronic respiratory disease;cohort;Cohort Studies;Collection;Communities;Conceptions;cost-effectiveness evaluation;COVID-19 impact;COVID-19 pandemic effects;Data;Data Element;design;Development;Diagnosis;Disease;disorder prevention;diversity and inclusion;early life exposure;Enrollment;Environment;Environmental Exposure;Environmental Risk Factor;Epithelial Cells;ethnic diversity;expectation;follow-up;Funding;Goals;Hispanic Populations;Hypersensitivity;Incidence;Individual;infancy;Infant;infant infection;Infection;Infrastructure;innovation;interest;Intervention;Licensure;Life;low and middle-income countries;Medical History;Mentors;middle childhood;Modification;Monoclonal Antibodies;multi-racial;Neonatal;Nose;novel;Outcome;pandemic disease;pandemic impact;Participant;policy implication;Population;Predisposition;pregnant;Pregnant Women;prevent;Prevention;Prevention strategy;Preventive;Primary Prevention;Protocols documentation;Public Health;public health intervention;Publications;pulmonary function;racial diversity;Recommendation;recruit;Recurrence;Research;Research Personnel;resilience factor;respiratory microbiome;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;Respiratory Syncytial Virus Vaccines;retention rate;Risk;Rural Community;Sampling;Severities;Southeastern United States;Testing;Urban Community;vaccine acceptance;Vaccines;Wheezing;Work

PROJECT_TITLE: ECHO Renewal for the CANOE Study Cohort

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-S(50)R]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Infectious Diseases;Lung;Prevention;Pulmonary Hypertension;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE We propose to develop an efficient means of detecting early stages of a lung blood vessel disease called pulmonary arterial hypertension. Such a tool would reduce the number of tests doctors must order to detect the disease in patients and could be used to estimate how common the disease is in a community. During this study we will collect clinical data, ultrasound images, and blood samples in order to determine how patients develop and can be diagnosed with this condition.

PI_NAMEs: GRAHAM, BRIAN BARKLEY;HILTON, JOAN F (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: accurate diagnostics;Africa South of the Sahara;Agreement;Attention;Biological Markers;Blood specimen;Blood Vessels;Calibration;Cardiac Catheterization Procedures;Characteristics;Classification;Classification Scheme;Clinic;Clinical;Clinical Data;Clinical Management;clinical predictors;clinical research site;cohort;Collaborations;Communities;Country;Data;Data Set;Development;Diagnosis;Diagnostic;diagnostic criteria;Diagnostic tests;diagnostic tool;Dimensions;Discrimination;Disease;Early Diagnosis;Early treatment;Echocardiography;Eligibility Determination;Enrollment;Epidemiology;Ethiopia;Etiology;exercise capacity;follow-up;Follow-Up Studies;Future;Guidelines;Hand;Helminths;high risk;Individual;Infection;innovation;insight;Letters;low and middle-income countries;Lung;Measures;Methods;Nature;noninvasive diagnosis;novel;novel marker;novel strategies;novel therapeutics;Outcome;Participant;participant enrollment;patient screening;Patients;Persons;phenomics;Phenotype;point of care;pre-clinical;predictive marker;predictive modeling;Prevalence;Probability;Prospective cohort;Prospective, cohort study;Protocols documentation;Provider;pulmonary arterial hypertension;Pulmonary Hypertension;pulmonary vascular disorder;Recording of previous events;research study;Resources;Risk;Risk Factors;Role;Sampling;Schistosoma;Schistosoma mansoni;Schistosomiasis;screening;Screening procedure;Site;standard of care;symposium;Technology;Testing;therapeutic target;Thrombospondin 1;tool;trend;Ultrasonography;Update;Validation;Visit;Zambia

PROJECT_TITLE: Screening for schistosomiasis-associated pulmonary arterial hypertension

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Drug Abuse (NIDA only);Mental Health;Natural Products;Neurosciences;Pediatric;Substance Misuse

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Initiation of cannabis use usually occurs during adolescence, which represents a vulnerable period in neurobiological development. The proposed research is designed to elucidate how chronic cannabinoid use during adolescence produces neural plasticity- that is changes in brain structure and function- related to short- and long-term behavioral adaptations exemplified by withdrawal and relapse-like behavior. Identifying these important adaptations may inform the development of novel therapies for cannabis use disorder.

PI_NAMEs: SPENCER, SADE MONIQUE (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: Abstinence;Address;Adolescence;Adolescent;Adolescent and Young Adult;Affect;Affective Symptoms;Amygdaloid structure;Anhedonia;Behavior;Behavioral;Brain;Brain region;Canis familiaris;cannabinoid withdrawal;Cannabinoids;Cannabis;cannabis seeking;cannabis withdrawal;cell type;Cerebral hemisphere;Chronic;Clinical;clinically significant;Communication;comparison control;Coupling;craving;critical period;cue reactivity;Cues;design;Development;DSM-V;Electrophysiology (science);endophenotype;experience;Female;FOS gene;Genetic;genetic manipulation;Glutamates;Hippocampus;Hour;illicit drug use;Immediate-Early Genes;Immunohistochemistry;immunoreactivity;In Vitro;in vivo;Incubated;Individual;Intravenous;Knowledge;Legal;Light;Link;Male Adolescents;Maps;marijuana use;marijuana use disorder;marijuana user;Measures;Medial;Mediating;Microscopy;Modeling;negative affect;neural;neuroadaptation;Neurobiology;Neuronal Plasticity;Neurons;neurophysiology;neuroregulation;neurotransmission;novel therapeutics;Nucleus Accumbens;optogenetics;Outcome;Output;Pathway interactions;Pharmaceutical Preparations;Pharmacotherapy;pre-clinical;Prefrontal Cortex;Prevalence;Process;Psychotropic Drugs;Rattus;Relapse;Relaxation;Reporter;Research;Research Domain Criteria;response;Rewards;Self Administration;Severities;Slice;Structure;Substance of Abuse;Substance Withdrawal Syndrome;Symptoms;Synapses;Synaptic plasticity;Synaptic Transmission;Techniques;Testing;Tetrahydrocannabinol;Thalamic structure;therapeutic target;Time;Tissues;transmission process;Treatment outcome;Tremor;Uncertainty;United States;Virus;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Glutamatergic plasticity that drives cannabinoid withdrawal and craving

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Estrogen;Genetics;Women's Health Research

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

ORG_STATE: MI

PHR: PROJECT NARRATIVE Germline and sporadic loss of function mutations in the tumor suppressor gene, NF1, drives a subset of breast cancer with increased metastatic potential, endocrine resistance, and dismal outcomes in disease. Here, I propose to study the mechanisms in which loss of neurofibromin-ERα interaction contributes to this aggressive subtype of breast cancers in order to identify tractable therapeutic options while receiving new training in next generation sequencing and analysis along with comprehensive analysis of cancer datasets. In the next phase of my career I will build upon this foundation of knowledge to expand my discoveries in identifying novel functions of NF1 and its role in cancer progression.

PI_NAMEs: DISCHINGER, PATRICK  (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Alternative Splicing;Award;biological adaptation to stress;Breast Cancer cell line;Breast Cancer Model;Breast Cancer Patient;breast cancer progression;Cancer Biology;career;Cell Cycle Regulation;Cell Line;Cell Physiology;Cells;Characteristics;crosslink;crosslinking and immunoprecipitation sequencing;Data;Data Analyses;Data Set;Diagnostic or Prognostic Factor;Disease;efficacy evaluation;Endocrine;environmental stressor;epigenomics;ESR1 gene;Estrogen receptor positive;Fellowship;fitness;fluorescence imaging;Foundations;Gene Expression;Gene Expression Regulation;Genes;genetic corepressor;Genetic Transcription;Germ Lines;Glioblastoma;Goals;Human;Impairment;in vivo;inhibitor;Invaded;Knowledge;Laboratories;leukemia;Link;loss of function;loss of function mutation;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Mammary Neoplasms;Mass Spectrum Analysis;Modeling;Molecular;Motivation;mutant;Mutate;Neoplasm Metastasis;next generation sequencing;NF1 gene;novel;novel diagnostics;novel therapeutic intervention;novel therapeutics;Nuclear;Nuclear Protein;Outcome;overexpression;Pathway interactions;Phase;Play;Post-Transcriptional Regulation;Postdoctoral Fellow;posttranscriptional;Process;Prognosis;Proliferating;Protein Isoforms;Proteins;Rattus;Regulation;Research;Research Personnel;Resistance;response;RNA;RNA Binding;RNA Splicing;RNA-Binding Proteins;RNA-Protein Interaction;Role;Selective Estrogen Receptor Modulators;Signal Transduction;skills;Spliced Genes;Spliceosomes;Techniques;Tertiary Protein Structure;Therapeutic;Therapeutic Intervention;therapy resistant;Training;Transcript;Transcription Process;Transcriptional Regulation;transcriptomics;tumor progression;Tumor Suppressor Genes

PROJECT_TITLE: Impact of neurofibromin on ER-alpha and nuclear speck post-transcriptional gene regulation


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Caregiving Research;Clinical Research;Health Services;Lung;Palliative Care;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative The rising incidence and decreasing mortality from acute respiratory failure (ARF) is leading to increasing numbers of ARF survivors who experience significant health impairments and increased healthcare utilization. Efforts to improve the long-term outcomes for ARF patients are hindered by the absence of a patient-centered and statistically efficient endpoint that is practical to measure in large cohorts and appropriate for assessing interventions with either palliative or restorative intents. This proposal aims to design and evaluate a method to quality-weight hospital-free days using patient-reported assessments of quality of life, function, or caregiver burden.

PI_NAMEs: AURIEMMA, CATHERINE LOUISE (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Acute;acute care;Acute respiratory failure;Admission activity;Adult;American;career development;Career Mobility;Caregiver Burden;Caregiver research;Caregivers;Clinical Trials;Cognitive;cohort;Cohort Studies;Consensus;Critical Care;Critical Illness;Data;Data Reporting;Death Rate;Dedications;design;Development Plans;digital;Electronic Health Record;Enrollment;Environment;evidence base;experience;Family;Family Caregiver;Family member;Financial Support;follow-up;Frequencies;functional status;Future;Goals;Health;health care service utilization;health goals;Home;hospital care;Hospital Mortality;hospital readmission;Hospitals;Impaired health;Impairment;improved;Incidence;innovation;Institution;instrument;Intensive Care Units;Interdisciplinary Study;International;Intervention;K-Series Research Career Programs;Knowledge;Lead;Lung;Measures;Mentors;Methodology;Methods;Modality;models and simulation;mortality;National Heart, Lung, and Blood Institute;novel;Outcome;Outcome Measure;palliative;patient engagement;patient oriented;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Pennsylvania;Physicians;Population;Positioning Attribute;Property;prospective;Prospective cohort;Prospective Studies;Prospective, cohort study;Psychometrics;psychosocial;Public Health;Quality of life;Quality of Life Assessment;randomized trial;Records;recruit;Reporting;Research;Research Design;Research Personnel;response;Sample Size;Scholarship;Science;Scientist;Site;skills;social;Statistical Models;Structure;success;Surveys;Survivors;survivorship;Techniques;Training;Translating;Universities;Weight;Work

PROJECT_TITLE: Developing and Evaluating Quality-Weighted Hospital-Free Days as a Novel, Patient-Centered Outcome for Trials of Patients with Acute Respiratory Failure

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Cancer;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Wound Healing and Care

ORG_CITY: NEW HAVEN

ORG_DEPT: GENETICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative Research into tissue repair holds tremendous impact to human health because improper repair after injury can lead to chronic wounds, severe complications, and even death. Tissue repair requires the coordination of many cell types, and recent advances show that many of these cells accumulate potentially oncogenic mutations that may affect the overall repair process and lead to cancer. We use novel microscopy approaches to study how these mutations affect wound repair, with therapeutic implications for both chronic wounds and cancer.

PI_NAMEs: GRECO, VALENTINA  (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Address;Affect;Age;age related;age related changes;aged;Behavior;Behavioral;cell behavior;cell type;Cells;Cellular biology;Cessation of life;chronic wound;clinically relevant;Collagen;Communication;Complex;coping;Data;Deposition;Dermis;Disease;Ear;Ensure;Environment;epidermal stem cell;Epidermis;Epithelial Cells;epithelial repair;epithelial stem cell;Epithelium;Equilibrium;Exhibits;experimental study;Extracellular Matrix;Failure;Fibroblasts;fitness;flexibility;Foundations;Gap Junctions;Genetic;Genetic Diseases;genetic manipulation;Goals;Growth;healing;Health;Homeostasis;Hour;Human;imaging approach;Imaging technology;improved;in vivo;Individual;Injury;injury and repair;innovation;Intestines;intravital imaging;intravital microscopy;Knowledge;Label;Laboratories;Malignant Neoplasms;Mammals;Mediating;Membrane;Microscopy;Modeling;mosaic;Mosaicism;mouse model;Mus;mutant;Mutation;novel;Oncogenic;Organ;Patients;pharmacologic;Physiological;Population;Prevention;Process;Proliferating;reconstruction;repaired;Research;Resolution;response;Role;self-renewal;Signal Pathway;Signal Transduction;single cell sequencing;Skin;Skin repair;Skin Tissue;Somatic Mutation;spatiotemporal;Squamous cell carcinoma;Structure;Testing;Therapeutic;Time;tissue repair;Tissues;tumor;Visualization;Work;wound closure;wound healing

PROJECT_TITLE: Understanding Skin Tissue Repair in Live Mammals

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: CINCINNATI

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Narrative: Trypanosoma cruzi is the etiological agent of Chagas disease, an illness affecting 6-7 million people worldwide, for which very few treatment options are available. Protein phosphorylation plays several key biological roles in the complex life cycle of the parasite, and protein kinases are known druggable targets in different eukaryotic pathogens. Here we propose to perform a barcode multigene-gene knockout screening in T. cruzi to identify essential protein kinases in the progression of the parasite’s life cycle.

PI_NAMEs: CHIURILLO, MIGUEL A (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Affect;Americas;Antiparasitic Agents;Atlases;Bar Codes;Biological;Biological Process;Blood Transfusion;C-terminal;Cell Cycle Progression;Cell Cycle Regulation;Cell Physiology;Cells;Chagas Disease;chemotherapy;Chronic Phase;Classification;co-infection;combat;Communicable Diseases;Communities;Complex;Country;Coupled;CRISPR/Cas technology;Cyclic AMP-Dependent Protein Kinases;deletion library;design;Detection;Development;Differentiation and Growth;Disease;DNA;DNA Repair Pathway;drug discovery;Drug Targeting;druggable target;Equipment and supply inventories;Etiology;Eukaryota;experimental study;fitness;Fluorescence Microscopy;Gene Deletion;Gene Silencing;Genes;Genetic;genetic approach;Genetic Drift;Genome;HIV;homologous recombination;Human;improved;Individual;Infection;inhibitor;Insect Vectors;insight;Intervention;Invaded;Investigation;Knock-out;knockout gene;Latin America;Leishmania;Libraries;Life Cycle Stages;Ligands;Malaria;Mammals;Mediating;Metabolism;Methodology;migration;molecular drug target;Molecular Target;Morphology;mutant;nanomolar;next generation sequencing;Nonhomologous DNA End Joining;Organ Transplantation;Organelles;Organism;Orthologous Gene;Parasites;pathogen;Pattern;Persons;Pharmaceutical Preparations;Phase II Clinical Trials;Phenotype;phosphoproteomics;Phosphorylation;Phosphotransferases;Play;Population;prevent;PRKR gene;Proliferating;protein function;Protein Kinase;Proteins;Regulation;Reporting;Research;Research Project Grants;response;reverse genetics;RNA Interference;Role;Scaffolding Protein;screening;side effect;Signal Pathway;Signal Transduction;Specificity;System;Testing;tissue culture;Toxic effect;Trypanosoma brucei brucei;Trypanosoma cruzi;vaccine access

PROJECT_TITLE: Barcode screening of essential protein kinases in the life cycle progression of Trypanosoma cruzi

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Depression;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Activity;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Serious Mental Illness;Social Determinants of Health;Women's Health Research

ORG_CITY: HADLEY

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

ORG_STATE: MA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because understanding how physical and mental health during pregnancy can help predict cardiovascular disease and mental health disorders in later adulthood is essential to women’s health. The specific objective of the proposed research is to examine the association of pregnancy complications and prenatal mental health with subsequent cardiometabolic profile and mental health in middle adulthood among Hispanics of Puerto Rican heritage living in the continental US, the Hispanic subgroup with the highest prevalence of diabetes, obesity, and major cardiometabolic risk factors. Study outcomes will inform culturally sensitive prenatal interventions for early life prevention of future chronic disorders in an understudied and particularly vulnerable population.

PI_NAMEs: CHASAN-TABER, LISA  (contact)

PROGRAM_OFFICER_NAME: MITCHELL, MEGAN S

PROJECT_TERMS: actigraphy;adiponectin;Adult;antepartum depression;Anxiety;bilingualism;Biological Markers;Birth;Blood Pressure;Body mass index;C-reactive protein;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;Cessation of life;Chronic;Chronic Disease;Data;Databases;Depressive disorder;Diabetes Mellitus;Diagnostic;Early Intervention;Europe;Event;experience;fasting glucose;Feasibility Studies;Follow-Up Studies;Future;Glycosylated hemoglobin A;Hair;Health;Health Status;High Density Lipoproteins;High Prevalence;high risk;Hispanic;Hispanic Populations;Hispanic Women;Homeostasis;Hydrocortisone;Inflammation;Insulin;Insulin Resistance;Interleukin-6;International;Interview;Interviewer;LDL Cholesterol Lipoproteins;Leptin;Life;Link;Lipids;Measures;Mediating;Medical History;Medical Records;Mental Depression;Mental disorders;Mental Health;Modeling;Modification;Mothers;novel;Obesity;Outcome;Outcome Study;Participant;perceived stress;Persons;Physical activity;physical conditioning;Physiological;poor sleep;Population;Population Growth;Postpartum Depression;Pre-Eclampsia;Predisposition;Pregnancy;Pregnancy Complications;pregnancy hypertension;Premature Birth;prenatal;prenatal intervention;Prevention;prospective;Prospective Studies;Psychosocial Stress;Public Health;Puerto Rican;Questionnaires;Registries;Research;Retrospective cohort study;Risk;Risk Factors;Sleep;Small for Gestational Age Infant;sociodemographics;Stress;Stress Tests;Subgroup;Surveys;trait;Triglycerides;Visit;Vulnerable Populations;waist circumference;Woman;Women's Health

PROJECT_TITLE: Cardiovascular Disease Risk Factors in At-Risk Hispanic Women following Pregnancy Complications

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Pediatric

ORG_CITY: MISSOULA

ORG_NAME: UNIVERSITY OF MONTANA

ORG_STATE: MT

PHR: Project Narrative This SEPA project will develop graphic novels (GN) and documentary (DOC) style videos to encourage STEM education in 7th and 9th grade students. The GN and DOC will be comprehensively evaluated during development for effectiveness and interest compared to traditional classroom delivery. Teachers participating in the program will receive professional development training to receive the skills necessary to confidently deliver the new materials. All finished products will be made freely available for dissemination.

PI_NAMEs: HOLIAN, ANDRIJ  (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Address;age group;Attitude;base;Biomedical Research;career;Career Choice;Collaborations;Communication;Confusion;curriculum development;Data;Data Analyses;design;Development;digital;digital delivery;digital platform;Education;Educational Curriculum;Educational Materials;Educational process of instructing;Educational workshop;Effectiveness;Ensure;Evaluation;experience;Experimental Designs;experimental study;Exposure to;Fantasy;Fostering;Future;girls;Goals;Growth;improved;Instruction;instrument;Intention;interest;Interest Group;Interview;Isometric Exercise;junior high school;Knowledge;Language;Learning;learning outcome;learning strategy;lectures;Literature;Memory;Methodology;Middle School Student;Misinformation;Mission;next generation;ninth grade;novel;Outcome;pedagogy;Perception;Population Heterogeneity;preference;Process;programs;Protocols documentation;Research;Research Personnel;Resources;Science;science education;Science, Technology, Engineering and Mathematics;Science, Technology, Engineering and Mathematics Education;scientific literacy;Series;seventh grade;skills;STEM career;STEM field;student participation;Students;teacher;Teacher Professional Development;Teaching Method;Testing;tool;Training;United States National Institutes of Health;willingness;Work

PROJECT_TITLE: Improving middle grade STEM interest and increased learning using GN and DOC

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


PHR: PROJECT NARRATIVE Dysfunction of the immune system has been implicated in the pathogenesis of several age-related lung diseases, including pneumonia, chronic obstructive pulmonary disease, and pulmonary fibrosis, suggesting that reversing or delaying age-related immune dysfunction may be an effective strategy for treating these diseases as a group. Our preliminary data supports a role for increases in inflammatory signaling within structural cells of the lung as a cause of aging-associated immune system dysfunction. The aim of this proposal is to understand how this inflammatory signaling induces immune system dysfunction, with the ultimate goal of identifying new potential therapeutic targets to treat age-related lung diseases.

PI_NAMEs: ALLEN, NANCY CHRISTINE (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: adaptive immunity;Address;Age;Age Factors;age related;aged;Aging;aging related;Alveolus;anti-PD-1;Antibodies;Automobile Driving;Basal Cell;Biological Assay;Biology;career;CD8-Positive T-Lymphocytes;CD8B1 gene;CDKN2A gene;Cell Aging;Cell Communication;Cell Cycle;Cell Cycle Arrest;Cells;Cellular Stress;chemokine;Chronic Obstructive Pulmonary Disease;Circulation;Coculture Techniques;Complex;cytokine;Dasatinib;Data;Development;differential expression;Disease;Elderly;emerging adult;epithelial stem cell;exhaustion;Exhibits;experience;Fibroblasts;Fibrosis;Gene Expression Profile;Genetic Models;Genetic Transcription;Goals;Health;Histology;Homeostasis;Hydroxyproline;I Kappa B-Alpha;Immune;Immune system;Immune System Diseases;Immunohistochemistry;Impairment;improved;In Vitro;in vitro testing;in vivo;in vivo evaluation;Infection;Inflammation;Inflammatory;Influenza;inhibitor;K-Series Research Career Programs;Kinetics;knock-down;Lung;Lung Diseases;lung health;Lung infections;lung repair;Lymphocyte;Lymphoid;Mentorship;Mesenchymal;Mesenchyme;Morbidity - disease rate;mortality;mouse model;Mus;Names;neutralizing antibody;novel;Nuclear;old mice;Pathogenesis;Pathologic;Phenotype;Physicians;Play;Pneumonia;Population;Production;programmed cell death protein 1;Pulmonary Fibrosis;Quercetin;recruit;Reporter;Research;Role;Scientist;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Signal Induction;Signal Transduction;single-cell RNA sequencing;Source;symposium;T-Lymphocyte;Testing;therapeutic target;therapy development;tissue injury;tissue repair;Tissues;Training;transcriptome sequencing;Transplantation;Uncertainty;Up-Regulation;Viral;Viral Load result;Viral Pneumonia;Virus Diseases

PROJECT_TITLE: Role of stromal inflammatory signaling in the aging of lung resident lymphocytes

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: CHAMPAIGN

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Drinking to relieve stress is among the most robust predictors of later onset of alcohol use disorder (AUD), but prior experimental studies have often failed to capture alcohol’s ability to boost mood in the face of stress. The current study is unique in that it looks to real-life drinking contexts to identify stressors capable of harnessing alcohol’s powerful stress-relieving capabilities. By examining “real life” stressful contexts, the current study could have a number of important conceptual and clinical implications, including for understanding mechanisms underlying AUD vulnerability, identifying individuals at risk for AUD, improving reinforcement- centered harm reduction and prevention focused interventions, and refining the understanding of “high risk” relapse settings for those in treatment. .

PI_NAMEs: FAIRBAIRN, CATHARINE  (contact)

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: addiction;Address;Alcohol abuse;Alcohol consumption;alcohol effect;alcohol reinforcement;alcohol reward;alcohol risk;alcohol use disorder;Alcohols;Automobile Driving;Beverages;Biological Markers;Biosensor;Brain;Brain imaging;Clinical;comparative;Consumption;contextual factors;design;disorder risk;drinking;drinking behavior;Early identification;Electroencephalography;Elements;Emotional;Etiology;experimental study;Genetic Complementation Test;Grant;Harm Reduction;harm reduction programs;hazardous drinking;Health Policy;Heavy Drinking;high risk;Image;imaging modality;improved;in vivo;indexing;Individual;innovation;Intervention;Investigation;Laboratories;laboratory experiment;Life;Link;Literature;Measures;Methodology;Methods;Modality;Modeling;Moods;multidisciplinary;multimodality;Nature;neural;neurobehavioral;neuroimaging;novel;Participant;Pattern;Persons;Photography;Prevention;Prevention program;Process;Property;Psychological reinforcement;Public Health;Randomized;Relapse;relapse risk;Reporting;Research;Research Personnel;response;Rewards;Risk;Role;Science;Scientist;Severities;Shock;social;social engagement;Social Environment;Social Interaction;Social Processes;Speech;Stimulus;Stress;stressor;Symptoms;Technology;Thalamencephalon;Theoretical model;Time;tool;Work

PROJECT_TITLE: Examining the Impact of Stress on the Emotionally Reinforcing Properties of Alcohol in Heavy Social Drinkers: A Multimodal Investigation Integrating Laboratory and Ambulatory Methods

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Nutrition

ORG_DEPT: PHYSIOLOGY

PHR: Project Narrative The proposed research is relevant to public health because it thoroughly tests how perturbations in cardiac mitochondrial Ca2+ impact the heart’s ability to produce energy and pump. By establishing the effects of cardiac mitochondrial Ca2+ increase and decrease on mitochondrial and organismal function in homeostasis, the proposed work represents a conceptual advance towards the NIH’s goal to gain fundamental knowledge of living systems. Furthermore, testing the effects of mitochondrial Ca2+ increase and decrease in two distinct mouse models of heart failure, and discerning when elevated or reduced Ca2+ is deleterious or beneficial, paves the way for significant progress in the NIH’s mission to reduce illness and disability.

PI_NAMEs: LIU, JULIA CHANG (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Address;Adrenergic Agents;Adult;Affect;Animal Model;Animals;aorta constriction;Basic Science;Calcium;Cardiac;Cardiac health;Cardiac Myocytes;Cause of Death;Cell Death;Clinical;Complex;Data;Diet;disability;Disease;Disease Outcome;Disease Progression;Echocardiography;EFRAC;Fatty acid glycerol esters;Fibrosis;functional decline;Functional disorder;Future;Gatekeeping;Genes;genetic manipulation;glucose tolerance;Goals;Heart;Heart Contractilities;Heart failure;heart failure with reduced ejection fraction;heart function;Histology;Homeostasis;Hypertension;Hypertrophy;Impairment;improved;in vivo;innovation;interest;Knowledge;Link;Literature;Maps;Measures;Mediating;Metabolic syndrome;Methodology;Mission;Mitochondria;mitochondrial permeability transition pore;Modeling;Molecular;mouse model;Multiprotein Complexes;Mus;Myocardial dysfunction;NG-Nitroarginine Methyl Ester;novel;Obesity;Operative Surgical Procedures;Organism;Outcome;Outcome Assessment;Outcomes Research;Oxidative Stress;Pathology;Permeability;Physiology;Play;preservation;pressure;Production;protein complex;protein expression;Proteomics;Public Health;Pump;Reporting;Research;Respiration;response;Role;Secondary to;Signal Pathway;Signal Transduction;Sucrose;Tamoxifen;Testing;Therapeutic;therapeutic development;therapy development;Time;Tissues;tool;United States National Institutes of Health;uptake;Ventricular Function;Work

PROJECT_TITLE: Modulating mitochondrial calcium in cardiac homeostasis and disease

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Despite chimeric antigen receptor (CAR) T cell immunotherapy mediating impressive response rates in B cell malignancies, fewer than 50% of patients experience long-term disease control. Elucidating T cell phenotype- function relationships is critical to informing future CAR T cell therapy design and cancer treatment. Toward that end, this study will characterize senescence in the context of CAR T cells, delineating the molecular roles of telomerase in T cells and identifying senescent markers correlated with patient features and treatment response on CAR T cell therapy.

PI_NAMEs: MURTY, TARA  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Address;Adoptive Cell Transfers;Age;Antigen Targeting;B lymphoid malignancy;beta-Galactosidase;Biology;Blood Component Removal;cancer therapy;CAR T cell therapy;career;Catalytic Domain;Cell Aging;Cell Physiology;Cell Therapy;Cells;Cellular biology;Cessation of life;Characteristics;Chemicals;Chemistry;chimeric antigen receptor;chimeric antigen receptor T cells;Chronology;Clinical;clinical predictors;Computer Analysis;Data;Dedications;Development;disorder control;Engineering;epigenome;exhaustion;experience;Fellowship;Functional disorder;Funding;Future;Genetic Engineering;Goals;Health;Human;Immunology;Immunotherapy;Incidence;Infusion procedures;innovation;insight;Interdisciplinary Study;Length;life span;Link;loss of function;Malignant Neoplasms;Measures;Mediating;Medical;medical schools;Medicine;Mentorship;Molecular;Multienzyme Complexes;next generation;novel;Oncology;Outcome;Patient-Focused Outcomes;Patients;Phenotype;Physicians;Population;predictive marker;programs;Proliferating;Recording of previous events;Research;Resources;response;Role;Scientist;senescence;senescent cell;Solid Neoplasm;Surface;T-Lymphocyte;Telomerase;Telomerase inhibition;telomere;Testing;Therapeutic;therapy design;Time;tool;Training;Training Programs;transcriptome;Treatment Efficacy;treatment response;Tumor Burden;Universities;Work

PROJECT_TITLE: Defining the Role of Senescence in Limiting Therapeutic Efficacy of CAR T Cells


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Osteoporosis

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project narrative Osteoporosis is a major public health problem, and orally-available treatments that stimulate bone formation are lacking. We have identified a new pathway that promotes bone formation. Here, we will define how this bone building pathway interacts with other hormones, and develop this novel approach to treat osteoporosis.

PI_NAMEs: WEIN, MARC NATHAN (contact)

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: Acute;adenylate kinase;aging population;Anabolic Agents;Bioenergetics;Biological;Blood;bone;bone cell;Bone Formation Stimulation;bone loss;bone mass;Bone Resorption;bone strength;Calcium;Cells;Chronic;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;Development;Disease;drug discovery;Endocrine;Female;Forteo;Genetic;Goals;Homeostasis;hormonal signals;hormone analog;hormone therapy;Hormones;Hyperparathyroidism;Hypogonadism;In Vitro;in vivo;inhibitor;Injections;insight;Insulin;Insulin-Like Growth Factor I;kinase inhibitor;Knowledge;Lead;male;Mediator;Medical;Methods;Modeling;Mus;Nature;next generation;novel;novel strategies;novel therapeutics;Oral;Oral Administration;Osteoblasts;Osteogenesis;Osteoporosis;Outcome;Output;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phosphatidylinositols;phosphoproteomics;Phosphorylation;Phosphotransferases;PIK3CG gene;pre-clinical;programs;Property;Proteins;Proto-Oncogene Proteins c-akt;PTH gene;Public Health;Research;response;Role;salt-inducible kinase;Signal Pathway;Signal Transduction;skeletal;Skeleton;small molecule;Structure;Testing;Therapeutic;Time;translational potential;Treatment Efficacy

PROJECT_TITLE: The role of salt inducible kinases in parathyroid hormone action in bone

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Substance Misuse

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative The prevalence of alcohol-associated liver disease (ALD) is rising in the United States. We proposed a mechanistic study to determine the role of lncRNA H19 in regulating mRNA alternative splicing events in the pathogenesis of alcohol-induced liver injury.

PI_NAMEs: YANG, ZHIHONG  (contact)

PROGRAM_OFFICER_NAME: LIN, LI

PROJECT_TERMS: Alcoholic Liver Diseases;Alcohols;Alleles;Alternative Splicing;Animal Model;Applications Grants;Betaine;Binding;Biological Assay;Birth;Cell model;Chromosome 11;Chromosome 7;Code;Data;differential expression;DNA;DNA Methylation;Docking;Embryo;Enhancers;Enzymes;Epigenetic Process;epigenetic regulation;Ethanol;Event;experimental study;Gene Cluster;gene conservation;Genes;Goals;Growth;H19 gene;H19 RNA;Heavy Drinking;Hepatic;Hepatocyte;Homocysteine S-methyltransferase;Human;Immunoprecipitation;imprint;Incidence;Inherited;Knock-out;Knockout Mice;Liver;Liver diseases;Mediating;Messenger RNA;Methionine Metabolism Pathway;Methylation;Molecular;mouse model;mRNA Expression;mRNA Precursor;Mus;N-terminal;novel;overexpression;paternal imprint;Pathogenesis;Pathway interactions;Patients;Phenotype;Polypyrimidine Tract-Binding Protein;Prevalence;Process;promoter;protein expression;Protein Methyltransferases;Proteins;Public Health;Regulation;response;RNA;RNA Splicing;RNA-Binding Proteins;Role;Sampling;Structure;Testing;Therapeutic Intervention;therapeutic target;Tissues;Transcriptional Regulation;United States;Untranslated RNA;Variant

PROJECT_TITLE: Long Noncoding RNA H19 Mediating Alternative Splicing in ALD Pathogenesis

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ORG_CITY: ATLANTA

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PI_NAMEs: COSKUN, AHMET F. (contact)

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;AIDS diagnosis;Animals;Antibodies;antiretroviral therapy;B-Cell Activation;B-Cell Development;B-Lymphocyte Subsets;B-Lymphocytes;Bioinformatics;CD4 Positive T Lymphocytes;Cell Communication;Cell Maturation;cell type;Cells;Coupled;cytokine;Cytokine Gene;Defect;Disease Progression;Emerging Technologies;Evolution;experience;Extracellular Matrix;Follicular Dendritic Cells;follow-up;Gene Expression;Gene Expression Profiling;Genes;Goals;high reward;high risk;HIV;Human;human subject;human tissue;Image;Immune;immune activation;Immune response;Immune system;Immunity;Immunology;immunoregulation;Impairment;Individual;Infection;Inflammation;innovation;insight;interdisciplinary approach;Interleukin-10;Investigation;Lymph Node Tissue;lymph nodes;Lymphoid Cell;Lymphoid Tissue;Macaca;Macaca mulatta;Maps;Memory B-Lymphocyte;Methods;Modeling;Molecular;mortality;multiple omics;Mutate;nonhuman primate;Pathogenesis;Pathology;Pathway interactions;Patients;peripheral blood;Persons;Phenotype;Plasma Cells;pre-clinical;protein distribution;Proteomics;Reaction;Regulation;Research;Research Personnel;Resolution;response;Role;secondary lymphoid organ;simian human immunodeficiency virus;Site;SIV;Spatial Distribution;spatiotemporal;Specialized Center;Structure;Structure of germinal center of lymph node;T cell regulation;T-Lymphocyte;Techniques;Technology;Testing;Tissues;transcriptomics;transmission process;Up-Regulation;Vaccinated;Viral;viral DNA;Virus;Virus Diseases

PROJECT_TITLE: Tracing spatial organization of germinal centers in rhesus macaques

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Climate-Related Exposures and Conditions;Infectious Diseases;Lung;Lymphatic Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Elderly people are more susceptible to respiratory tract infections. Pulmonary macrophages are among the first cell types to respond to all the environmental exposures (e.g., air pollution) and functional discrepancies in this innate immune cell subset can increase the severity of diseases such as influenza due to aggravated inflammation; however, age-associated changes in pulmonary macrophages that are under constant influence of the environment exposures is not well studied. This proposal is designed to investigate the hypothesis that atmospheric particulate matter is contained within the macrophages and due to these particulates, aging pulmonary macrophages have altered transcriptional profile with compromised respiratory immune responses.

PI_NAMEs: URAL, BASAK BURCU (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Activities of Daily Living;Affect;Age;age related;age related changes;aged;Aging;Air Pollution;airway immune response;Alveolar Macrophages;Atmosphere;Award;B-Lymphocytes;Biology of Aging;Brain Death;brain tissue;Carbon;career;cell type;Cells;Collaborations;Computer Analysis;confocal imaging;Coronavirus;cytokine;Data;Death Rate;demographics;design;draining lymph node;Elderly;Environment;Environmental Exposure;Environmental Impact;environmental particulate;experience;Exposure to;Flow Cytometry;Future;Gene Expression Profile;healthcare burden;high dimensionality;Homeostasis;Human;human tissue;Image;Imaging technology;Immune;Immune response;Immune system;Immunity;immunoregulation;Immunotherapy;Impairment;Inflammation;Inflammatory Response;Influenza;influenza infection;innovation;Life;Lung;Lung Diseases;lymph nodes;Lymphatic;lymphatic drainage;Macrophage;Malignant Neoplasms;Mentors;mesenteric lymph node;migration;mouse model;Mus;neoplastic;Organ Donor;Organism;Paper;particle;Particulate;Particulate Matter;pathogen;Patients;Persons;Phagocytosis;Population;Population Heterogeneity;Postdoctoral Fellow;Predisposition;Production;Property;pulmonary function;Research Personnel;Respiratory Disease;respiratory pathogen;Respiratory Tract Diseases;Respiratory Tract Infections;Role;Scientist;senescence;Severity of illness;Shapes;single cell sequencing;Site;Structure of parenchyma of lung;Tissues;Training;transcriptome;transcriptomics;Transgenic Mice;two-photon;uptake;Virus Diseases;Work

PROJECT_TITLE: Impact of Environmental Exposures on Lung Immunity over Age

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Prevention;Serious Mental Illness;Substance Misuse;Suicide;Suicide Prevention;Telehealth

ORG_CITY: DURHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Recently discharged psychiatric inpatients who misuse alcohol are at high risk for suicide. The proposed project involves the development of a novel intervention that would enhance care for these individuals by pairing inpatient-based emotion regulation skills training with a mobile health application that extends this treatment into the post-discharge period. Through acquisition and eventual utilization of emotion regulation skills to replace maladaptive, stress-induced emotion-driven behaviors (e.g., heavy drinking, suicide attempts), this approach could reduce post-discharge risk for a suicide crisis and costly rehospitalization.

PI_NAMEs: GROVE, JEREMY  (contact)

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: acceptability and feasibility;Acute;acute care;Address;Admission activity;Adult;Alcohol consumption;alcohol misuse;alcohol related consequences;Alcohols;Ambulatory Care;Area;arm;Back;Behavior;Behavior Therapy;Behavioral;care seeking;career;Caring;Cessation of life;Client satisfaction;Clinical;Clinical Trials;Clinical Trials Design;Cognitive;cohort;cost;cost effective;Coupled;Dangerousness;Data;design;Development;Ecological momentary assessment;Educational Intervention;emotion regulation;Emotions;Environment;Evaluation;experience;Feedback;Feeling suicidal;follow-up;Goals;Health Services Accessibility;Heavy Drinking;high risk;high risk population;hospital readmission;Hospitalization;Individual;innovation;inpatient psychiatric treatment;inpatient service;Inpatients;Intervention;Life;Long-Term Care;Mentored Patient-Oriented Research Career Development Award;Mentors;Methodology;mHealth;Mobile Health Application;Modeling;Modification;National Institute of Mental Health;National Institute on Alcohol Abuse and Alcoholism;novel;novel strategies;Outcome;Outpatients;Participant;Patient Discharge;Patients;Persons;Phase;Prevalence;primary outcome;programs;Protocols documentation;psychiatric inpatient;Psychiatric therapeutic procedure;Public Health;public health priorities;Randomized;Randomized, Controlled Trials;Recommendation;Recovery;recruit;Reporting;Research;Research Personnel;Resolution;Risk;Risk Factors;Risk Reduction;Role;secondary outcome;skills;skills training;Societies;standard care;Statistical Models;Stress;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;sustained recovery;therapy development;Time;tool;Training;treatment as usual;Treatment Efficacy;trial comparing;Underserved Population

PROJECT_TITLE: Development of mHealth-Supported Skills Training for Alcohol and Related Suicidality (mSTARS): Emotion Regulation Skills Training to Enhance Acute Psychiatric Care and Recovery

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_DEPT: CHEMISTRY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Project Narrative One of the most significant barriers to health-related research involving small molecules is the rapid assembly of therapeutic agents. This proposal seeks to develop new methods to synthesize complex frameworks using easily accessible precursors with high efficiency.

PI_NAMEs: ROVIS, TOMISLAV  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Asymmetric Synthesis of Nitrogen Heterocycles

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: CORAL GABLES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: OVERALL NARRATIVE We will renew, continue and expand our effort to describe, understand, intervene on, and mitigate the Alzheimer’s disease health disparities experienced by American Indians, Alaska Natives, Native Hawaiians, and Pacific Islanders by studying mid- and late-life resilience and risk factors. We will achieve this goal by funding social and behavioral Pilot Studies that advance the field, emphasizing the recruitment and mentorship of Native junior and mid-level researchers. These trainees will receive training on methods and analyses so that their work meets high scientific standards, while being culturally appropriate. This work will advance Alzheimer’s disease research and increase the number of independent investigators focused on Alzheimer’s disease disparities experienced by our target populations.

PI_NAMEs: GALVIN, JAMES E (contact);JOHANSSON, PATRIK LENNART

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Address;African American;Aging;aging brain;Alaska Native;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American Indians;Arizona;Articulation;Award;Awareness;Behavioral;behavioral and social science;Behavioral Research;Biometry;Brain;career;career development;Cherokee Indian;Cholesterol;clinical investigation;Clinical Sciences;Cognitive;Communities;Community Networks;community partnership;Country;Data;dementia risk;demographics;Discipline;disease disparity;Doctor of Philosophy;education research;Elderly;Emotional;Epidemiology;epidemiology study;experience;Face;Faculty;Funding;Goals;Grant;Hawaii;Health;health disparity;Heart;High Prevalence;high risk;Human;human old age (65+);Hypertension;improved;Indigenous;Individual;Infrastructure;innovation;interest;late life;Leadership;Life Cycle Stages;Life Expectancy;low socioeconomic status;Measures;Mental Depression;Mentors;Mentorship;Methodology;Methods;middle age;mild cognitive impairment;Mind;Minority;Minority Groups;minority investigator;modifiable risk;Native Hawaiian or Other Pacific Islander;Nature;New Mexico;Non-Insulin-Dependent Diabetes Mellitus;Obesity;older adult;Outcome;outreach;Personal Satisfaction;Persons;Pilot Projects;Play;Population;Premature aging syndrome;Principal Investigator;programs;Psyche structure;Publications;racism;recruit;Reporting;Research;Research Design;Research Methodology;Research Personnel;Research Priority;resilience;resilience factor;Resources;Review Committee;Risk;Risk Factors;Role;Satellite Centers;Scientist;Services;Smoking;social;Social isolation;Spirituality;study population;success;Target Populations;theories;Training;Underrepresented Minority;Universities;vascular risk factor;Vocational Guidance;Washington;Work

PROJECT_TITLE: Native Alzheimer Disease Resource Center for Minority Aging Research (NAD-RCMAR)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Rural Health

PI_NAMEs: GALVIN, JAMES E (contact)

PROJECT_TERMS: Advisory Committees;Affect;African American;Aging;Alaska Native;Alzheimer's Disease;Alzheimer's disease related dementia;American Indians;Area;Articulation;Behavioral;brain health;Budgets;Cherokee Indian;Clinical;Clinical Trials Data Monitoring Committees;Collaborations;college;Communication;Communities;Community Outreach;data sharing;Education;education research;Educational process of instructing;Elderly;Ensure;Epidemiology;Evaluation;experience;Faculty;Goals;health disparity;Health Personnel;Human Resources;improved;Institution;International;late life;Leadership;Measurement;medical schools;Medicine;meetings;Mentors;Methodology;mid-career faculty;middle age;Minority;minority communities;Minority Groups;minority investigator;minority scientist;Mission;Monitor;Native Hawaiian or Other Pacific Islander;Nature;Neurology;novel;operation;Oral;outreach;Pilot Projects;Policies;Preparation;Principal Investigator;Process;professor;programs;promoter;psychologic;Publications;recruit;Regulation;Research;Research Activity;research faculty;Research Methodology;Research Personnel;resilience;resilience factor;Resources;Review Committee;Risk Factors;Safety;Satellite Centers;Scholarship;Science;Scientist;service delivery;Site;social;study population;success;Supervision;Training;Travel;Underrepresented Minority;Universities;Washington;Writing


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Heart Disease;Nutrition;Obesity;Physical Activity;Prevention

ORG_CITY: WASHINGTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Public Health Relevance Cardiovascular diseases (CVD) are a leading cause of morbidity and premature death, and it is crucial to enhance preventive efforts. High blood levels of branched-chain amino acids can have adverse effects on CVD risk, but it remains unclear whether diet, physical activity, and weight loss can substantially lower their levels. Findings from this project can inform personalized lifestyle recommendations for CVD prevention.

PI_NAMEs: VAN DAM, ROB M. (contact)

PROGRAM_OFFICER_NAME: BROWN, ALISON GWENDOLYN MARY

PROJECT_TERMS: Adverse effects;Affect;African American;Animals;arm;Behavioral;Biological;Biological Markers;Blood;blood lipid;Blood Pressure;Body Weight;Body Weight decreased;Branched-Chain Amino Acids;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular risk factor;Catabolism;Cessation of life;Cohort Studies;Complement;Counseling;Cross-Sectional Studies;DASH diet;Data;diabetes risk;Diet;dietary;Dietary Factors;Dietary Fatty Acid;Dietary Practices;Dietary Proteins;Dyslipidemias;Edible Plants;Essential Amino Acids;exercise intensity;experimental study;Female;fitness;fruits and vegetables;Genetic study;glucose metabolism;group intervention;gut microbiota;Health;high risk;Hour;Hypertension;improved;indexing;Individual;Inflammation;inflammatory marker;Insulin Resistance;insulin sensitivity;Intake;Intervention;intervention effect;Interview;Isoleucine;Leucine;Life Style;lifestyle factors;lifestyle intervention;Link;Lipoproteins;Longitudinal Studies;Measurement;Measures;Meat;Mendelian randomization;metabolomics;Morbidity - disease rate;Nitrogen;Non-Insulin-Dependent Diabetes Mellitus;novel;nutrition;Obesity;Outcome Measure;Overweight;Participant;Pattern;personalized intervention;Physical activity;Plants;Plasma;premature;Prevalence;Preventive;preventive intervention;Production;protein intake;Proteins;public health relevance;Randomized;randomized trial;Recommendation;red meat consumption;repository;Research;Risk Factors;Sampling;Serum;targeted treatment;Therapeutic Intervention;urinary;Urine;Valine;Weight Gain

PROJECT_TITLE: Lifestyle, branched-chain amino acids, and cardiovascular risk factors: a randomized trial


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: SUCHY-DICEY, ASTRID M (contact)

PROJECT_TERMS: Address;Affect;Aging;aging related disease;Alaska Native;Alzheimer's Disease;Alzheimer's disease related dementia;American Indians;Applications Grants;Behavioral Research;Biological Markers;Biometry;Birth;career;Clinical;Clinical Data;Clinical Research;Cognition;cohort;Collaborations;comorbidity;Computerized Medical Record;Consultations;Data;Data Analyses;Data Collection;Data Coordinating Center;data management;data repository;Data Set;data sharing;Databases;dementia risk;design;Diagnosis;Disparity;education research;Epidemiology;Ethnic Population;experience;Funding;Goals;Grant;Health;health disparity;health equity;improved;Incidence;Instruction;Knowledge;Learning;Mentors;Methodology;Methods;Minority;Native Hawaiian or Other Pacific Islander;Outcome;Participant;patient stratification;Persons;Pilot Projects;Play;Policies;Population;population based;Population Study;Positioning Attribute;pressure;Prevalence;programs;Public Health;public health research;Publications;racial population;Reporting;Research;Research Activity;Research Design;research faculty;Research Personnel;Research Project Grants;resilience;resilience factor;Resources;Risk;risk stratification;Role;Sample Size;Sampling;Scientist;social;social health determinants;socioeconomic disparity;Structure;success;Surveys;Techniques;Training;undue influence;United States Dept. of Health and Human Services;Work;Writing


NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative This project aims to develop new computational models and tools for the discovery and optimization of synthetic processes harnessing organic radical intermediates. Control over the generation, reactivity, and enantioselectivity of triplet diradicals will be studied, and general predictive models for the site selectivities of homolytic substitutions will be developed and validated. Conceptual advances will be harnessed to create a practical and broadly applicable computational platform for (i) developing radical strategies for the preparation of new drug candidates and (ii) predicting small molecules’ metabolic stabilities.

PI_NAMEs: PATON, ROBERT SCOTT (contact)

PROJECT_TERMS: Acceleration;Acids;Address;Alkenes;Catalysis;catalyst;Chemistry;chlorination;Collaborations;Complex;computational platform;Computer Models;computerized tools;Coupled;Cyclization;cycloaddition;Cytochrome P450;Degradation Pathway;design;Development;drug candidate;drug-like compound;Electronics;Energy Transfer;Generations;Goals;guided inquiry;halogenation;Halogens;Hydrogen;insight;intermolecular interaction;Kinetics;Machine Learning;machine learning model;Mediating;Medicine;Metabolic;Metabolism;Methods;Modeling;Modernization;Molecular;novel therapeutics;oxidation;Pharmaceutical Chemistry;predictive modeling;predictive tools;Preparation;Process;programs;Protocols documentation;Rationalization;Reaction;reaction rate;Reagent;Research;Role;screening;Site;small molecule;Structure;Synthesis Chemistry;Thermodynamics;tool;Triplet Multiple Birth;triplet state

PROJECT_TITLE: Computational Models for New Developments in Radical Chemistry


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: BUCHWALD, DEDRA S (contact)

PROJECT_TERMS: Address;Aging;Alaska Native;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American Indians;Applications Grants;Arizona;Articulation;Behavioral Research;Brain;career;career development;Clinical Research;Clinical Treatment;Collaborations;Communication;Communities;curriculum development;Data;Databases;Death Rate;dementia risk;didactic education;education research;Educational workshop;Ensure;epidemiology study;ethnic minority;experience;Extramural Activities;Faculty;field study;Funding;Goals;Grant;Health Disparities Research;health disparity;health disparity populations;Health Policy;High Prevalence;Home;improved;Indigenous;Influentials;Infrastructure;innovation;Institution;Journals;late life;Lead;Leadership;Literature;Measurement;Mentors;MeSH Thesaurus;Methodology;middle age;Mind;Minority;Minority Groups;minority investigator;Modeling;modifiable risk;Native American Research Center for Health;Native Hawaiian or Other Pacific Islander;New Mexico;Participant;Persons;Pilot Projects;programs;Publications;Publishing;PubMed;Race;racial minority;Research;Research Activity;Research Design;Research Methodology;Research Personnel;Research Project Grants;research study;resilience factor;Resources;Risk Factors;Scientist;Series;skills;social;standard care;Training;Training Activity;Underrepresented Minority;United States National Institutes of Health;Universities;Washington;Work


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Food Allergies;Precision Medicine;Rare Diseases

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PUBLIC HEALTH NARRATIVE Patients with Eosinophilic Gastroenteritis (EGE) suffer for years without a diagnosis or adequate therapy due to lack of understanding of risks and markers for disease. Identification of immune markers reflecting immune underpinnings and phenotypes of disease will improve the identification, comprehension, and diagnosis of the disease. Furthermore, recognition of familial risks for EGE will aid clinicians in their diagnostic path, empowering them to diagnose disease early on, and treat adequately, avoiding increased medical costs and complications of disease.

PI_NAMEs: ALLEN-BRADY, KRISTINA LISA;PETERSON, KATHRYN A (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Abdomen;Abdominal Pain;Age;age group;Asthma;Biological Markers;biomarker identification;Biopsy;CCL17 gene;CCL26 gene;Chronic;clinical phenotype;comorbidity;Comprehension;cost;Data;Databases;Development;Diagnosis;Diagnostic;Diarrhea;Diffuse;Disease;disease diagnosis;Disease Marker;disease phenotype;disorder subtype;duodenitis;Dyspepsia;Early Diagnosis;Eczema;empowerment;Endoscopy;eosinophil;Eosinophilia;Eosinophilic Esophagitis;Eosinophilic Gastritis;eosinophilic gastroenteritis;Eosinophilic Gastrointestinal Disease;Eosinophilic Infiltrate;Etiology;Family;Family history of;Family member;First Degree Relative;gastrointestinal;Gastrointestinal tract structure;Gender;Genealogy;Genetic Transcription;Healthcare;high risk;Immune;Immune response;Immune signaling;Immunologic Markers;Immunologics;immunopathology;improved;Infiltration;Inflammation;Interleukin-5;Intestines;Irritable Bowel Syndrome;Link;Mediating;Medical Care Costs;medical complication;Medical Records;molecular phenotype;Morbidity - disease rate;Onset of illness;Pathologic;patient subsets;Patients;personalized management;Phenotype;Population Database;predictive signature;proband;Protocols documentation;Public Health;Publishing;Race;Relative Risks;Risk;Risk Factors;RNA;Second Degree Relative;Stomach;Symptoms;therapeutically effective;Tissues;transcriptome sequencing;TSLP gene;Up-Regulation;Utah;Work

PROJECT_TITLE: Relationship of Immune Responses to Clinical Phenotype and Familial Risk in Eosinophilic Gastroenteritis


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Obesity;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: This application leverages the national ECHO Cohort dataset to examine risk and protective factors for children’s mental health problems and obesity, with a focus on understanding sex-specific associations, identification of prevention and intervention targets, and generalization of findings to communities of color. We also propose to retain the socioeconomically and racially diverse CANDLE sample in the ECHO Program, reconsenting participants into the new ECHO Protocol and collecting high-quality, complete data from the urban South. Our team brings a strong record of consortium leadership and partnerships across the ECHO Cores and Cohorts, which we will continue in the next phase of the ECHO Program to advance collaborative science and improve the health and well-being of all children.

PI_NAMEs: BUSH, NICOLE RENEE;LEWINN, KAJA ZABRINA;ZHAO, QI  (contact)

PROGRAM_OFFICER_NAME: ZANETTI, KRISTA A

PROJECT_TERMS: Address;Adolescence;Adolescent;Adolescent obesity;Adult;Affect;African American;Age;age group;Behavior;Buffers;central database;Chemicals;Child;child depression;Child Development;Child Health;Child Mental Health;Child Rearing;Childhood;children of color;Clinical;Clinical Psychology;cohort;Cohort Analysis;Collaborations;Color;Communities;COVID-19 pandemic;Data;Data Element;data harmonization;Data Set;depressive symptoms;Development;Diagnostic;disability-adjusted life years;Disease;early childhood;Early identification;Elements;Ensure;Environment;Epidemiology;Evaluation;experience;Family;Future;Health;health equity;improved;indexing;Inequity;Intergenerational Relations;Intervention;Lead;Leadership;Life;maternal stress;Measurement;Measures;Mental Depression;Mental Health;Methods;middle childhood;modifiable risk;Mothers;Neighborhoods;novel;Obesity;obesity risk;Outcome;Outcome Measure;Participant;participant enrollment;Personal Satisfaction;Phase;Phenotype;physical conditioning;population based;Pregnancy;Prevention;preventive intervention;programs;Properdin;protective factors;Protocols documentation;Psychopathology;Public Health;Publishing;racial diversity;Recommendation;Records;Research;Research Personnel;Risk;Risk Factors;Sampling;Scanning;Science;sex;social;sociodemographics;socioeconomics;Specificity;Stress;study population;success;Symptoms;Visit;working group;years of life lost

PROJECT_TITLE: Retaining the diverse CANDLE cohort to advance ECHO Cohort solution-oriented research and identify early-life modifiable risk factors for obesity and mental health problems in children

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-S(50)R]


NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Behavioral and Social Science;Bioengineering;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Immunotherapy;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Persistent racial and ethnic disparities in colorectal cancer (CRC) mortality remain a public health concern. Focusing on survival, this project will identify novel biomarkers and create a prognostic index that suggests therapeutic targets and more precise patient stratification for personalized treatments, with the potential to improve outcomes in CRC patients that may particularly benefit those racial and ethnic groups with high CRC mortality. This research will provide me with cutting-edge cross-disciplinary research experience in the rapidly growing field of integrative tumor epidemiology.

PI_NAMEs: YIN, HANG  (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Address;African American;African American population;Age;Alaska Native;Alaska Native population;Algorithms;Automobile Driving;Biological;Biological Markers;Cancer Biology;Cancer Control;Cancer Etiology;cancer health disparity;cancer immunotherapy;Cancer Prognosis;cancer survival;cell type;Cells;Cellular biology;cellular imaging;Cessation of life;Characteristics;Clinical;Collaborations;colon cancer patients;Colorectal Cancer;Complex;Computer Analysis;Computing Methodologies;Consensus;Data;Death Rate;Dedications;density;Development;differential expression;dimension reduction;Disease Outcome;Disease Progression;Disparity;Environment;Epidemiology;ethnic disparity;ethnic diversity;Ethnic Origin;Ethnic Population;experience;Family;Formalin;Gene Expression Profile;Gene set enrichment analysis;General Population;Genes;Genetic Transcription;Goals;Hand;Health Services Accessibility;Heterogeneity;High-Frequency Microsatellite Instability;Hispanic;Image;Imaging technology;Immune;immune cell infiltrate;Immune Evasion;improved outcome;insight;Investigation;Knowledge;lens;Life Style;Linear Regressions;Logistic Regressions;machine learning algorithm;Malignant Neoplasms;Medical Records;Microsatellite Instability;Modeling;Molecular;Molecular Epidemiology;molecular marker;Molecular Profiling;molecular subtypes;mortality;mortality disparity;multidimensional data;multidisciplinary;Mutation;Native Americans;Neighborhoods;Nested Case-Control Study;Normal tissue morphology;Not Hispanic or Latino;novel;novel marker;Outcome;Paraffin Embedding;Pathway Analysis;Pathway interactions;patient population;patient stratification;Patients;personalized medicine;Persons;Phase;Population Heterogeneity;Postdoctoral Fellow;pre-doctoral;predictive tools;Probability;Prognosis;Prognostic Factor;prognostic index;Protocols documentation;Public Health;Race;racial disparity;racial diversity;racial population;Recording of previous events;Recurrence;Research;Research Personnel;response;Risk Factors;Role;Sampling;screening;sex;Shapes;single cell analysis;single cell technology;skills;Smoking Status;Statistical Data Interpretation;Statistical Methods;T-cell inflamed;therapeutic target;Training;training opportunity;transcriptome;transcriptome sequencing;transcriptomics;translational research program;tumor;tumor heterogeneity;Tumor Immunity;tumor immunology;tumor microenvironment;tumor progression;Tumor Tissue;tumorigenesis;United States;Validation;Weight

PROJECT_TITLE: Transcriptome and spatial analyses of tumor environment in addressing colorectal cancer racial and ethnical disparities


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Opioid Misuse and Addiction;Opioids;Patient Safety;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Treatment with buprenorphine is effective and is typically initiated in an office-based setting, however the process of starting buprenorphine is increasingly complicated by precipitated withdrawal for individuals using fentanyl. Withdrawal during buprenorphine initiation reduces interest in treatment and increases the risk of drop-out and relapse. This project proposes to test a novel approach to initiating buprenorphine that can be completed in 10 hours in outpatient settings without requiring or precipitating opioid withdrawal.

PI_NAMEs: KAMPMAN, KYLE MATTHEW (contact);THAKRAR, ASHISH PRAKASH

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Absence of pain sensation;Abstinence;addiction;Adherence;Affinity;Aftercare;arm;Buprenorphine;buprenorphine treatment;Case Series;Case Study;Chronic;Clinical;Clinical Trials;design;Dose;Dropout;Drug Kinetics;efficacy testing;experience;Fentanyl;fentanyl use;fentanyl use disorder;Goals;Heroin;Hospitalization;Hospitals;Hour;Hydromorphone;Illicit Drugs;improved;Individual;innovation;Inpatients;interest;Licensing;lipophilicity;Maintenance;Measures;Methodology;Monitor;Morbidity - disease rate;mortality;mu opioid receptors;Norfentanyl;North America;novel;novel strategies;Opioid agonist;Opioid Receptor Binding;opioid use;opioid use disorder;opioid withdrawal;Outpatients;Overdose;overdose risk;Participant;Patients;Pennsylvania;Persons;Pharmaceutical Preparations;Pilot Projects;pilot trial;Plasma;prevent;primary care setting;primary outcome;Process;Protocols documentation;Public Health;public health priorities;Randomized;Randomized, Controlled Trials;recruit;Regulation;Relapse;Research;Retrospective cohort study;Risk;Safety;safety study;safety testing;Sampling;secondary outcome;Speed;success;Surveys;synthetic opioid;Testing;Therapeutic;Time;Universities;Urine;Withdrawal;Work

PROJECT_TITLE: Rapid outpatient low-dose initiation of buprenorphine for individuals with OUD using fentanyl

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Allergic Rhinitis (Hay Fever);Asthma;Behavioral and Social Science;Burden of Illness;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Eczema / Atopic Dermatitis;Food Allergies;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: DETROIT

ORG_NAME: HENRY FORD HEALTH SYSTEM

PHR: Project narrative Atopic conditions (atopic dermatitis (AD), food allergy, asthma and allergic rhinitis) pose a significant social and financial burden to children and families; however, the fundamental descriptive epidemiology trends for severe atopic multimorbidity or SAAM (AD, food allergy, asthma with or without allergic rhinitis) are unknown for US children, and current clinical practice lacks an early biomarker to identify infants at risk. In conjunction with ECHO-wide committee and working group participation, proposal submissions, and manuscripts, this project will assess incidence rates of SAMM to target populations at risk and use placental DNA methylation to identify potential biomarkers linking social and environmental conditions to disease outcomes. The proposed investigations and scientific collaborations across ECHO will more precisely identify children at risk for multiple atopic co-morbidities which is an important first step in preventing childhood atopic disease co-morbidity and improving the health of children across the US.

PI_NAMEs: EAPEN, AMY ;JOHNSON, CHRISTINE C ;STRAUGHEN, JENNIFER K. (contact)

PROGRAM_OFFICER_NAME: MASH, CLAY

PROJECT_TERMS: 6 year old;Address;Age;Air Pollution;Airway Disease;Allergic;Allergic Disease;Allergic rhinitis;Anxiety;Asthma;Atopic Dermatitis;atopy;Biological Markers;Birth;burden of illness;Categories;Child;Child Health;Childhood;clinical practice;cohort;Collaborations;Community Health Aides;comorbidity;Country;Data;Demographic Factors;Descriptive Epidemiology;design;Development;Diet;Disease;Disease Outcome;disease phenotype;disorder risk;DNA Methylation;early detection biomarkers;Early identification;early life exposure;Endocrine;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiological trend;Epidemiology;Epigenetic Process;equity, diversity, and inclusion;Ethnic Origin;European ancestry;Family;fetal;Fetal Development;Financial Hardship;follow-up;Food Aversion;Food Hypersensitivity;Gene Expression;Gene Expression Regulation;Geography;Growth;Health;Hypersensitivity;Immune;Immune system;improved;Incidence;Infant;innovation;Intake;interest;Intervention;intrauterine environment;Investigation;Link;Manuscripts;maternal stress;Maternal-Fetal Exchange;Mediating;Mental Depression;Metabolic;Methylation;methylation pattern;methylome;middle childhood;Minority Groups;multiple chronic conditions;Neonatal;Neurocognitive Deficit;Nutrient;obesity in children;offspring;Organ;Outcome;Participant;Pathway interactions;Pattern;Persons;Phenotype;Physical activity;Placenta;Population;Populations at Risk;potential biomarker;predictive marker;pregnant;prenatal;prenatal environmental exposure;prenatal exposure;prenatal influence;Prevalence;prevent;Prevention;programs;Protocols documentation;Quality of life;Race;Research;Research Personnel;Risk;Risk Factors;Role;School-Age Population;sex;Site;Sleep disturbances;social;socioeconomics;Target Populations;Time;Tissues;United States National Institutes of Health;Voice;Whole Blood;working group

PROJECT_TITLE: Epidemiology of multimorbid pediatric atopic and airway diseases and the impact of prenatal maternal environmental exposures and placental epigenetics


ORG_CITY: MILWAUKEE

ORG_NAME: VERSITI WISCONSIN, INC.

ORG_STATE: WI

PHR: PROJECT NARRATIVE Fibrinolysis is a key regulator of bleeding severity, and long-lasting knockdown of plasminogen using gene therapy tools has the potential to mitigate fibrinolysis, blood loss, and re-bleeding in early stages of hemorrhage, thus decreasing morbidity and mortality. The RNA therapeutics developed in this study to knock down plasminogen will (1) elucidate the role of fibrinolysis at the onset of acute bleeding, which will answer a fundamental mechanistic question in the biochemistry of hemostasis; and (2) provide proof-of-concept in small and large animal models that siRNA targeting plasminogen can be used to manage bleeding in a wide variety of genetic and acquired bleeding disorders. The results will enable development of these RNA therapeutics into novel “universal” therapeutics that could overcome the limitations of current antifibrinolytic strategies to treat many types of diagnosed and undiagnosed bleeding disorders, thus improving the quality of life for the nearly one million Americans suffering from bleeding disorders.

PI_NAMEs: KASTRUP, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Acute;American;Animal Model;Animals;Antifibrinolytic Agents;Antiplasmin;Biochemistry;Bleeding time procedure;Blood Coagulation Disorders;canine model;Canis familiaris;Clinical;Coagulation Process;comparison control;Data;Development;Diagnosis;Disease;disease model;Dose;Enzyme Precursors;Enzymes;Equilibrium;Family suidae;FDA approved;Fibrinolysis;Fibrinolytic Agents;Gene Silencing;gene therapy;Genetic;Half-Life;Health;Hemophilia A;Hemophilia B;Hemorrhage;Hemostatic Agents;Hemostatic function;Hour;improved;in silico;In Vitro;in vivo;Incidence;Inherited;Injury;innovation;insight;Investigation;joint injury;knock-down;Knowledge;lipid nanoparticle;Measures;Mediating;Menorrhagia;Methods;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Nerve;novel;Operative Surgical Procedures;Outcome;Patients;Persons;Plasmin;Plasminogen;Plasminogen Activator Inhibitor 1;porcine model;Predisposition;prevent;Process;prophylactic;Prophylactic treatment;Proteins;Puncture procedure;Quality of life;Research;Research Personnel;RNA;RNA-targeting therapy;Role;Rupture;Safety;Saphenous Vein;Severities;Small Interfering RNA;small molecule inhibitor;Symptoms;Tail;targeted agent;targeted treatment;Testing;Therapeutic;therapeutic nanoparticles;therapeutic RNA;therapy development;tool;Toxic effect;Tranexamic Acid;Trauma;Traumatic Hemorrhage;Traumatic injury;von Willebrand Disease;Woman;Work

PROJECT_TITLE: Understanding and Controlling the Contribution of Fibrinolysis to Bleeding Using a Long-Acting Antifibrinolytic RNA Therapy

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ORG_CITY: TUCSON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Narrative Current control strategies for mosquito-borne pathogens largely rely on reducing mosquito vector populations using insecticides but this approach is becoming less effective as insecticide resistance develops against many mosquito adulticides and larvicides. We have developed novel pH responsive compounds capable of delivering a range of toxic payloads to the larval gut and its unique high pH conditions. This provides an opportunity to develop highly specific larvicides with minimal effects on non-target organisms and the flexibility to switch toxic compounds if resistance develops.

PI_NAMEs: JEWETT, JOHN C (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TITLE: Disrupting the mosquito larval midgut using novel pH responsive compounds

STUDY_SECTION: TVZ

STUDY_SECTION_NAME: Transmission of Vector-Borne and Zoonotic Diseases Study Section [TVZ]


NIH_SPENDING_CATS: Clinical Research;Hematology;Pediatric;Precision Medicine;Prevention;Rare Diseases;Sickle Cell Disease

ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Despite the known association between hypercoagulability and sickle cell disease (SCD), venous thromboembolism (VTE) has remained an understudied complication of pediatric SCD, leading to a scarcity of data on VTE outcomes and hindering the optimal management of VTE in children with SCD. This project aims to elucidate clinical and molecular risk factors for incident and recurrent VTE among children with SCD, and to apply these findings to the development of prognostic models for VTE in this population, by means of a multicenter prospective-retrospective cohort study with parallel biospecimen banking. The aims of this study align with the NIH research priorities in SCD by providing critical knowledge to better predict long-term outcomes in this population, implementing the use of biomarkers as means of identifying patients with SCD at high risk for adverse clinical events, and providing much-needed scientific evidence to guide effective management strategies aimed at reducing adverse VTE outcomes in children with SCD and VTE.

PI_NAMEs: BETENSKY, MARISOL  (contact)

PROGRAM_OFFICER_NAME: NEIDERT, LESLIE EAVES

PROJECT_TERMS: Accounting;Achievement;acute chest syndrome;Address;Adult;Affect;African;Anti-Inflammatory Agents;Anticoagulants;antithrombin III-protease complex;Area;Area Under Curve;Attention;Award;biobank;Biological;Biological Assay;Biological Markers;Biological Specimen Banks;biomarker development;biomarker discovery;biomarker validation;Black race;career;career development;Case/Control Studies;Catheters;Cell Adhesion;Cell Adhesion Molecules;Cessation of life;Child;Childhood;Chronic;Clinical;Clinical Data;Clinical Investigator;clinical prognostic;clinical risk;Coagulation Process;Cohort Studies;Complication;Computerized Medical Record;Country;Coupled;Cytolysis;Data;Databases;design;Development;Development Plans;Disease;early onset;Endothelium;Event;Frequencies;Future;Genotype;Goals;Hematological Disease;Hemoglobin SS;high risk;Hospitalization;improved outcome;Incidence;Individual;Inflammation;Inflammatory;Inherited;interest;Interleukin-6;Interleukins;Intervention Studies;Intervention Trial;Investigation;Knowledge;Life;Logistic Regressions;Low income;Mass Spectrum Analysis;Mentors;Methods;Minority;Modeling;Molecular;novel;novel marker;Observational Study;Organ;Outcome;P-Selectin;Packed Red Blood Cell Transfusion;Pathogenesis;Pathway interactions;Patients;Pediatric Hematology;pediatric patients;Persons;Pharmaceutical Preparations;Plasma;Population;Prevention trial;Primary Prevention;Prognostic Factor;prognostic model;prognostic signature;prospective;Proteomics;Recording of previous events;Recurrence;Regression Analysis;Research;Research Personnel;Research Priority;Retrospective cohort;Retrospective cohort study;Risk;Risk Factors;risk stratification;Secondary Prevention;Secondary to;Sickle Cell Anemia;Specimen;Splenectomy;System;Thrombophilia;Thromboplastin;Training;Training and Education;translational scientist;United States;United States National Institutes of Health;Validation;vascular endothelial dysfunction;Venous;venous thromboembolism;Work

PROJECT_TITLE: Clinical and Molecular based prognostic factors for Venous Thromboembolism (VTE) in Children with Sickle Cell Disease

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Brain Disorders;Clinical Research;Emerging Infectious Diseases;Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Neurosciences;Rare Diseases;Tuberculosis

ORG_CITY: BOSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: PROJECT NARRATIVE Tuberculosis (TB) can lead to severe neurological dysfunction when infection spreads to the CNS (CNS-TB) and is the cause of significant neurological complications around the world. Here we will use single cell and single nuclei RNA-sequencing of human brain and CSF samples from patients with CNS-TB, along with a spectrum of rodent models that represent different severities of CNS-TB, to determine how different cell types contribute to human CNS-TB. We will work to build single cell/single nuclei RNA-seq research capacity at the University of Cape Town by developing research infrastructure in South Africa and facilitating skills transfer through a structured training and skills development program.

PI_NAMEs: DULLA, CHRIS G (contact);FIGAJI, ANTHONY AARON;HOCKMAN, DORIT ;JACOBS, MUAZZAM ;ROHLWINK, URSULA

PROGRAM_OFFICER_NAME: SRINIVASAN, SUDHA

PROJECT_TERMS: 2019-nCoV;Affect;Africa;African;Biochemistry;Biological;Brain;Brain Diseases;Brain Pathology;brain tissue;C3HeB/FeJ Mouse;career;Cell Communication;Cell Death;Cell Nucleus;Cell Physiology;cell type;Cells;Cellular biology;Central Nervous System Tuberculosis;Cessation of life;Clinical;clinical phenotype;Communities;Computational Biology;Data;Data Analyses;Development;Diagnosis;differential expression;Disease;Education;Event;Fatality rate;Future Generations;Gene Expression Profile;Gene Expression Profiling;Generations;Genetic Transcription;Goals;Granulomatous;Growth;Healthcare;Human;human data;human disease;Human Pathology;human RNA sequencing;Immune;Immune signaling;Immune system;Immunocompromised Host;Immunohistochemistry;improved;Infection;Inflammatory;Infrastructure;innovation;insight;Invaded;Libraries;Meningeal Tuberculosis;Meningitis;Molecular;Molecular Target;mouse model;Mouse Strains;Mus;Mycobacterium tuberculosis;Neuroimmune;neuroinflammation;Neurologic;Neurologic Dysfunctions;Neuropathogenesis;next generation;novel;novel therapeutics;Outcome;pathogen;Pathogenesis;Pathway interactions;Patients;Peripheral;Persons;Phenotype;Preparation;Program Development;Reagent;recruit;Research;Research Infrastructure;Resected;response;Rodent;Rodent Model;Sampling;Scientist;Severities;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;skill acquisition;skills;South Africa;Specificity;Structure;synergism;Testing;Therapeutic;Therapeutic Intervention;TNF gene;Training;transcriptome sequencing;transcriptomics;Translating;Treatment outcome;Tuberculoma;Tuberculosis;Universities;Work

PROJECT_TITLE: Using Single Cell Biological Approaches to Understand CNS TB

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CN-T(55)R]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Autoimmune Disease;Biotechnology;Digestive Diseases;Immunization;Inflammatory Bowel Disease;Lung;Orphan Drug;Rare Diseases

ORG_CITY: Juno Beach

ORG_NAME: AQUALUNG THERAPEUTICS CORP.

PHR: NARRATIVE PUBLIC HEALTH RELEVANCE: Inflammatory Bowel Disease is a debilitating disease without a cure, a serious unmet need. The inflammatory protein, eNAMPT (extracellular nicotinamide phosphoribosyltransferase), is a key driver of unchecked inflammation and a highly novel therapeutic target and candidate gene in IBD. Our Phase I/II goals are to validate and optimize the eNAMPT- neutralizing humanized mAb, ALT-100, as a therapeutic strategy for IBD, and to complete IND-enabling studies that will facilitate ALT-100 development in human IBD trials.

PI_NAMEs: GARCIA, JOE G. N. (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Acute;Acute Respiratory Distress Syndrome;Address;Arizona;Biological Response Modifier Therapy;Bioreactors;Biotechnology;Candidate Disease Gene;cell bank;Chronic;Clinical Research;Clinical Trials;Collaborations;Colonic inflammation;curative treatments;cytokine;Data;Development;Disease;Doctor of Philosophy;Dose;Drug Kinetics;druggable target;efficacy trial;Exhibits;extracellular;Family suidae;Fibrosis;first-in-human;Formulation;Genetic Polymorphism;Genetic Transcription;genome wide association study;Goals;Growth Factor;Half-Life;healthy volunteer;Human;humanized monoclonal antibodies;improved;indexing;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Injury;Intestines;Investigational Drugs;Italy;Ligation;Link;Malignant neoplasm of prostate;Malignant Neoplasms;manufacture;Miniature Swine;Molecular;Monoclonal Antibodies;mouse model;murine colitis;Mus;Natural Immunity;neutralizing monoclonal antibodies;New Drug Approvals;new therapeutic target;nicotinamide phosphoribosyltransferase;novel;novel therapeutics;organ injury;Pathway interactions;Patients;Pattern;Pharmacodynamics;pharmacokinetic characteristic;Phase;phase 2 study;Physicians;Plasma;pre-clinical;professor;Property;protein expression;Proteins;public health relevance;Publishing;Pulmonary Hypertension;Radiation Fibrosis;radiation-induced lung injury;Rattus;Research;response;Route;Running;Safety;Science;Scientist;Serum;Severities;Severity of illness;Small Business Technology Transfer Research;Sprague-Dawley Rats;stable cell line;Stimulus;systemic inflammatory response;Talents;Therapeutic;therapeutic candidate;Therapeutic Intervention;Tissues;TLR4 gene;Toxic effect;Toxicokinetics;Toxicology;Universities

PROJECT_TITLE: Targeting the eNAMPT/TLR4 pathway to reduce Inflammatory Bowel Disease severity


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative: The gut houses billions of resident microbes, including bacteria, viruses, and fungi that actively support human health; however, when unbalanced, these microbes can activate various immune responses that cause disease or increase disease severity, such as cancer, autoimmunity and infection. This proposal seeks to examine how gut microbes impact health and disease through immune cell activation and immune structure formation. Understanding the mechanisms by which the gut microbiota support these immune structures during disease will contribute greatly to our ability to treat patients with chronic difficult to treat diseases, including cancer, autoimmunity, and cancer.

PI_NAMEs: OVERACRE-DELGOFFE, ABIGAIL E (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;Adult;Autoimmunity;Automobile Driving;B-Lymphocytes;Bacteria;career;Cells;Chronic;Colitis;Collaborations;Colon;colon bacteria;Colorectal Neoplasms;Communities;Development;Disease;dysbiosis;Ensure;Environment;field study;Follicular Dendritic Cells;Foundations;fungus;Gastrointestinal tract structure;Goals;Growth;gut microbes;gut microbiota;Health;Helicobacter hepaticus;Helper-Inducer T-Lymphocyte;high reward;high risk;Homeostasis;host microbiota;Human;Immune;immune activation;immune cell infiltrate;immune health;Immune response;Immune System Diseases;immunogenic;Immunologics;Immunology;in vivo;Infection;Inflammation;Inflammatory;ITGAM gene;Knowledge;Lymphangiogenesis;Lymphatic;lymphatic development;Lymphatic Endothelial Cells;lymphatic vessel;Lymphoid Tissue;Macrophage;Malignant Neoplasms;Mediating;member;Microbe;microbiome;microbiota;mouse model;Mucous Membrane;Mus;novel;patient prognosis;Patients;Polysaccharides;post-doctoral training;Production;programs;Regulation;Research;Research Personnel;Resources;response;Role;Severity of illness;Signal Transduction;spatiotemporal;Structure;Structure of germinal center of lymph node;success;System;T cell infiltration;T-Lymphocyte;tertiary lymphoid organ;Testing;transcriptomics;tumor;Tumor Immunity;Universities;Up-Regulation;Vascular Endothelial Growth Factors;Virus;Work

PROJECT_TITLE: Dissecting microbiota-driven lymphangiogenesis in immune health and disease