ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Harm Reduction for Substance Misuse;Pediatric;Prevention;Substance Misuse;Underage Drinking

ORG_CITY: AMHERST

ORG_DEPT: PSYCHOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: PROJECT NARRATIVE This study will characterize interpersonal processes (dominance and warmth) during parent- adolescent dyadic discussions about alcohol use using the Continuous Assessment of Interpersonal Dynamics (CAID) observational coding system, and will test whether these interpersonal dynamics and parenting style impact parental alcohol-specific socialization. Dominance and warmth dynamics and parenting style are expected to render parents’ efforts at harm reduction (discussing potential harms of drinking and allowing children to sip/taste alcohol) more or less effective. The current study will include a longitudinal sample of early adolescents and a parent to better understand the impact of parental alcohol-specific socialization on early adolescents’ alcohol attitudes and beliefs and trajectories of drinking.

PI_NAMEs: COLDER, CRAIG R (contact)

PROGRAM_OFFICER_NAME: BALACHOVA, TATIANA NIKOLAYEVNA

PROJECT_TERMS: 12 year old;Address;Adolescence;Adolescent;Age;Alcohol abuse;Alcohol consumption;alcohol risk;alcohol use initiation;Alcohols;Attitude;Behavioral;Belief;Benign;Characteristics;Child;Child Behavior;Child Rearing;Climate;Code;Cognitive;Communication;Data;drinking;dyadic interaction;early alcohol use;expectation;Family;follow-up;Frequencies;Future;Goals;Grant;Harm Reduction;Health;health goals;insight;Institute of Medicine (U.S.);Interpersonal Relations;Intervention;longitudinal design;Mediator;Modeling;National Institute on Alcohol Abuse and Alcoholism;National Research Council;Nature;Observational Study;Outcome;Parents;Predisposition;preventive intervention;Process;psychosocial;Public Health;Research;responsible alcohol use;Risk;Risk Reduction;Sampling;Shapes;Socialization;Source;Supervision;Taste Perception;Teenagers;Testing;theories;time interval;underage drinking;Work;Youth

PROJECT_TITLE: Parent-adolescent alcohol discussions and parent alcohol socialization

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Neurosciences;Pediatric;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: TAMPA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: The goal of this research is to develop a novel image-guided low intensity focused ultrasound (LIFU) based therapeutic modality for effectively treating alcohol use disorder (AUD). We propose to assess behaviors related to affect and to alcohol-seeking in order to identify the neurological processes on which LIFU is exerting its effects, and to examine the molecular effects in the brain following LIFU treatment in order to identify both the network response to LIFU, and to determine whether there are any adverse effects on neuronal function following chronic LIFU treatment. For these studies, we will use male and female crossed high-alcohol-preferring mice, in order to identify whether there are sex-dependent differences in the effects of LIFU on alcohol-seeking, or in the neuronal effects of LIFU.

PI_NAMEs: GULICK, DANIELLE ;JIANG, HUABEI  (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Abstinence;acamprosate;Acute;addiction;Adolescent;Adverse effects;Affect;alcohol abstinence;Alcohol abuse;alcohol abuse therapy;alcohol availability;alcohol behavior;Alcohol consumption;alcohol preferring mice;alcohol seeking behavior;alcohol sensitivity;alcohol use disorder;Alcohols;Animal Model;Behavior;Behavior assessment;Behavior Therapy;Behavioral;Biomedical Engineering;Brain;brain reward regions;Chronic;Clinical;Clinical Research;Collaborations;comorbidity;compulsion;conditioned place preference;Corticosterone;cost;Coupled;craving;Data;Deep Brain Stimulation;deprivation;disability;Disease;Disulfiram;Dizziness;drinking;Drowsiness;drug of abuse;Drug usage;Economic Burden;economic cost;Elements;Ensure;Environment;Ethanol Metabolism;Fatigue;FDA approved;Female;Focused Ultrasound;Focused Ultrasound Therapy;Foundations;Goals;Health;health economics;hemodynamics;Hypothalamic structure;image guided;imaging modality;Implantation procedure;Implanted Electrodes;in vivo;inflammatory marker;Inpatients;interest;Knowledge;Laws;Life;life span;Longevity;male;Mechanics;Medial;millimeter;millisecond;Modality;Modeling;Molecular;Mus;Naltrexone;negative emotional state;Nervous System Disorder;neural;Neurologic Process;Neuronal Plasticity;Neurons;neuroregulation;novel;novel therapeutics;Nucleus Accumbens;Operant Conditioning;optoacoustic tomography;Oxidative Stress;Patients;Pattern;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Physiological;Plasma;Population;preference;Prefrontal Cortex;premature;prevent;Process;Protocols documentation;Punishment;reduced alcohol use;Reflex action;Relapse;Reporting;Research;Resolution;response;Rewards;Risk Factors;Role;Route;Self Administration;Sex Differences;side effect;Sleep Disorders;socioeconomics;spatiotemporal;standard care;Stimulus;Stress;Structure;Substance Use Disorder;success;Surveys;System;Technology;Testing;Therapeutic;Therapeutic Intervention;Time;Tissues;tomography;Translations;Treatment Efficacy;Treatment Side Effects;ultrasound;United States;Ventral Tegmental Area;Withdrawal Symptom;Work

PROJECT_TITLE: Mechanisms underlying the reduction in alcohol intake in response to low intensity targeting of the reward circuit

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: CHICAGO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Mycobacterium tuberculosis (Mtb), the causative agent of the disease tuberculosis (TB), is estimated to infect one-fourth of the world's population, resulting in approximately 1.6 million deaths each year. There is a critical need to better understand the mechanisms of TB immunopathogenesis, as such mechanisms can be targeted to improve host control of Mtb infection. The work proposed in this R01 renewal will further elucidate the mechanisms by which inducible Bronchus Associated Lymphoid Tissue (iBALT) - containing granulomas confer protection against TB and will test approaches for clinically improving iBALT formation and limiting neutrophil accumulation. The knowledge to be gained from these studies is significant, as it will advance the development of new therapeutics and vaccine strategies for limiting TB reactivation and progression to TB.

PI_NAMEs: KAUSHAL, DEEPAK ;KHADER, SHABAANA A. (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Acceleration;Address;Advanced Development;Animal Model;Animals;Antibody Response;Antigen Presentation;B-Lymphocyte Subsets;B-Lymphocytes;BCG Live;Bronchus-Associated Lymphoid Tissue;Cells;Cessation of life;chemotherapy;Chronic;Clinical;Coin;combat;design;Disease;Disease Progression;Drug resistance;experimental study;extensive drug resistance;Funding;Goals;Granuloma;Growth;Human;humoral immunity deficiency;Immune;immune activation;Immunologic Stimulation;Immunologics;improved;Inflammatory;inhibitor;Integrins;Interleukin-6;Intervention;ITGAM gene;Knowledge;lifetime risk;Lung;Lymphoid Follicle;Mediating;Modeling;mouse model;Mucous Membrane;Multi-Drug Resistance;Mus;Mycobacterium bovis;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;nanoemulsion;neutrophil;nonhuman primate;novel;novel strategies;novel therapeutics;novel vaccines;Pathway interactions;Population;Predisposition;prevent;Proteins;Pulmonary Tuberculosis;rational design;receptor;Regulation;resistant strain;restraint;Role;S100A8 gene;Sampling;Side;Signal Transduction;small molecule inhibitor;Structure;Structure of germinal center of lymph node;Testing;therapy design;Tuberculosis;tuberculosis treatment;Tuberculosis Vaccines;vaccine access;vaccine response;vaccine strategy;Vaccines;Work

PROJECT_TITLE: Role of Inducible Bronchus Associated Lymphoid Tissue in Latent Tuberculosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-S(02)]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: AUSTIN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative  The use of hMSCs to treat diverse diseases has recently shown an exponential increase in demand; therefore, it could become a big problem if the cell manufacturing field cannot accommodate the production line to supply future needs. Currently, many of the static in-vitro substrates, conventional culture, and bioreactors systems have offered a substantial benefit for generating high cell numbers, but with limited therapeutic capabilities. This proposal aims to address that limitation by designing a dynamic composite of electrospun- fibers encapsulated in a hydrogel that replicate the dynamic mechanics and topographical structure of native ECM toward high hMSCs production with relevant therapeutic value.

PI_NAMEs: CASTILLA-CASADIEGO, DAVID  (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: 3-Dimensional;Address;Adhesives;Adipocytes;Affect;Allogenic;angiogenesis;Behavior;Biocompatible Materials;biophysical properties;Biophysics;Bioreactors;Cell Count;Cell Culture System;Cell Physiology;Cell Proliferation;Cell surface;Cell Survival;Cells;Characteristics;Chemicals;Chondroblast;Clinical effectiveness;Coculture Techniques;Collagen;Collagen Type I;crosslink;Cues;cytokine;density;design;Diameter;Disease;Electrospinning;Encapsulated;Engineering;Ensure;Extracellular Matrix;Fiber;Future;Goals;Human;Human body;Hyaluronic Acid;Hydrazones;Hydrogels;immunoregulation;improved;In Vitro;in vivo;Individual;insight;Integrin Binding;Length;Link;Lymphocyte Suppression;manufacture;manufacturing scale-up;Measures;mechanical properties;mechanical signal;Mechanics;Memory;Mentors;Mesenchymal Stem Cells;Methods;Molecular;Morphology;nanofiber;Nanotopography;Osteoblasts;patient population;Phase;Phenotype;Play;Production;Proliferating;Property;Proteins;Relaxation;Reporting;Reproducibility;Research;Research Proposals;Role;Rosales;scaffold;Secretory Cell;sensor;Signal Pathway;Source;stem cell expansion;stem cells;Stress;Structure;Supervision;Surface;System;Testing;Therapeutic;three-dimensional modeling;Tissues;transcription factor;Transcriptional Activation;viscoelasticity

PROJECT_TITLE: Regulating the Quality and Potency of Stem Cells with Biophysical Cues from Dynamic Nanofibrous Hydrogels for Therapeutic Purposes


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Pediatric

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Entrance into adolescence is marked by increased reward seeking and impulsivity, in both human and animal models. This project will investigate how functional and anatomical development of the medial prefrontal cortex contributes to adolescent behavior. Revealing age related differences in neuronal circuits is critical to understanding why animal’s propensity to exhibit certain behaviors change with age and could provide insight into possible biomarkers and predictors of for non-normative behavioral development.

PI_NAMEs: MANZANO NIEVES, GABRIELA  (contact)

PROGRAM_OFFICER_NAME: CHURCHILL, JAMES D

PROJECT_TERMS: Address;Adolescence;Adolescent;Adolescent Behavior;Adolescent Development;Adult;Advisory Committees;Age;age difference;age related changes;anatomical tracing;Anatomy;Animal Model;Animals;Area;Atlases;Basic Science;Behavior;behavior change;Behavioral;Biological Markers;Brain;Calcium;career;career development;cell cortex;Cells;Code;Cognitive;Communities;Cues;Data;Data Analyses;Decision Making;design;Detection;Development;Discrimination;Disease;early adolescence;emotion regulation;Equilibrium;Exhibits;expectation;Experimental Designs;Failure;Feedback;feeding;Fiber;flexibility;Future;Genetic;Glutamates;human model;Image;Impulsivity;Influentials;insight;Learning;Life;Link;Longitudinal Studies;Medial;Mental disorders;Mentors;Motivation;Mus;neural;neuronal circuitry;Neurons;Neurosciences;optogenetics;Outcome;Peripheral;Phase;Photometry;Play;postnatal development;Prefrontal Cortex;Property;Regulation;Research;response;Rewards;Role;Sensory;sensory stimulus;Shapes;Signal Transduction;Sucrose;Task Performances;Techniques;Testing;theories;tool;Training;transmission process;two-photon;Ventral Tegmental Area;Work

PROJECT_TITLE: Implications of Prefrontal Cortex Development for Adolescent Reward Seeking Behavior


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Diabetes;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Gestational diabetes mellitus (GDM) is the most common metabolic complication of pregnancy and is associated with an increased risk of adverse pregnancy outcomes and future type 2 diabetes mellitus (T2DM). The proposed studies will examine how human endocrine pancreatic function changes during and after pregnancy, and how women with and without GDM differ in terms of their glycemic control. The proposed work may identify pathways leading to GDM and postpartum T2DM which can be targeted in novel prevention and treatment strategies.

PI_NAMEs: EGAN, AOIFE MARIA (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Acceleration;adverse pregnancy outcome;Affect;Alpha Cell;Area;Autopsy;Beta Cell;blood glucose regulation;C-Peptide;career development;Cell Physiology;Clinic;Clinical Endocrinology;Clinical Investigator;clinical risk;Clinical Sciences;Compensation;Data;Defect;Development;Diabetes Mellitus;Diabetes prevention;Diagnosis;Discipline of obstetrics;early pregnancy;effective intervention;experience;Faculty;Fasting;Fetal Growth;First Pregnancy Trimester;Foundations;Functional disorder;Future;Gestational Diabetes;Glucagon;Glucose;glucose disposal;glucose metabolism;glucose production;glucose tolerance;glycemic control;Goals;Health;high risk;High Risk Woman;Human;human data;human model;Hyperglycemia;Impairment;improved;in vivo;indexing;Individual;insight;Insulin;insulin secretion;insulin sensitivity;Intervention;islet;Islet Cell;Islets of Langerhans;Knowledge;Late pregnancy;Leadership;Master of Science;Measurement;Measures;Mediating;Mentors;Metabolic;Methodology;Mission;Modeling;Morbidity - disease rate;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Obesity;OGTT;Oral;Overweight;Pathogenesis;Pathway interactions;Physicians;Physiological;Population;post pregnancy;Postpartum Period;Pregnancy;Pregnancy Complications;Prevention;Prevention strategy;Program Development;Prospective Studies;Prospective, cohort study;Recovery;Reproducibility;Research;research and development;Research Personnel;Residual state;Resolution;Risk;Risk Factors;risk stratification;Role;Sampling;Sensitivity and Specificity;skills;Techniques;Testing;Time;tool;Tracer;Training;Translational Research;treatment strategy;United States;Woman;Women's cohort;Women's study;Work

PROJECT_TITLE: Elucidating the Pathophysiology of Gestational Diabetes Mellitus

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Substance Misuse

ORG_CITY: CHARLESTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative  Alcohol-associated liver disease (ALD) with its associated fibrosis/cirrhosis is the major cause of liver- related mortality. Here, we investigate how ethanol ingestion produces hepatic mitochondrial depolarization (mtDepo) leading to mitochondrial autophagy (mitophagy), release of mitochondrial damage-associated molecular patterns (mtDAMPs) like mitochondrial DNA (mtDNA), and profibrotic responses by collagen fiber- producing hepatic stellate cells. Success of this project will allow development of new mechanism-based therapeutics to treat and prevent alcoholic liver disease.

PI_NAMEs: LEMASTERS, JOHN J;ZHONG, ZHI  (contact)

PROGRAM_OFFICER_NAME: MURRAY, GARY

PROJECT_TERMS: Abdomen;Acetaldehyde;Acute;Adenine Nucleotides;Alcohol consumption;Alcoholic Liver Diseases;Alcohols;aldehyde dehydrogenases;Aldehydes;Attention;Binding;Biogenesis;Cholesterol;Chronic;Cirrhosis;Collagen;Collagen Fiber;Conditioned Culture Media;Cyclic GMP;Dangerousness;Development;Diet;Disease;DsRed;Dyes;end stage liver disease;Ethanol;Ethanol Metabolism;Fibrosis;Fluorescence;fluorophore;functional restoration;Generations;Hepatic;Hepatic Stellate Cell;Hepatocyte;Human;In Vitro;in vivo;inhibitor;Kinetics;Label;Liver;Liver diseases;Liver Fibrosis;liver inflammation;liver injury;Liver Mitochondria;Membrane;Membrane Potentials;Metabolic;Mitochondria;mitochondrial autophagy;Mitochondrial DNA;Mitochondrial Swelling;Molecular;mortality;Movement;multiphoton imaging;Mus;NADH;oxidation;Oxygen Consumption;Parkin;Pathway interactions;Pattern;Permeability;PINK1 gene;prevent;Process;Proliferating;Proteins;Protons;Rattus;receptor;Recovery;Respiration;response;restoration;Role;Rupture;Signal Transduction;Source;Steatohepatitis;stellate cell;success;Swelling;synergism;Therapeutic;Time;TLR9 gene;Ubiquitination;UCP2 protein;Work

PROJECT_TITLE: Mitochondrial depolarization, mitophagy, and mitochondrial DAMPs in ALD

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Mental Health;Palliative Care;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it proposes to test a new psychosocial intervention that addresses a critical intervention gap in current psychosocial care for patients living with advanced lung cancer, the most common advanced cancer associated with high rates of psychological distress and poor quality of life, and which disproportionately affects rural, socioeconomically disadvantaged adults. Because the intervention was designed with patient needs and clinical practice in mind, it could easily be implemented in routine advanced cancer care in both academic and community oncology settings and could be exported for use among the over 600,000 people living with advanced cancer in the U.S. Thus, the proposed research will support the National Cancer Institute’s mission of reducing the burden of cancer through high quality cancer care.

PI_NAMEs: MCLOUTH, LAURIE  (contact)

PROGRAM_OFFICER_NAME: STRECK, BRENNAN PARMELEE

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Advanced Malignant Neoplasm;Affect;Age;Anxiety;anxiety symptoms;Attention;Behavioral Sciences;Cancer Burden;cancer care;Cancer Center;Cancer Patient;Cancer Survivorship;cancer therapy;care delivery;Caregivers;Caring;Clinical;clinical practice;Clinical Trials;Community Clinical Oncology Program;community setting;Data;depressive symptoms;design;Diagnosis;Distress;Effectiveness;Effectiveness of Interventions;effectiveness trial;efficacy evaluation;efficacy testing;efficacy trial;end of life;evidence base;Family;Feedback;follow-up;Friends;Future;Goals;Health Care Costs;Health Personnel;health related quality of life;Immunotherapy;Impairment;improved;Incidence;Infusion procedures;innovation;Intervention;intervention delivery;intervention effect;Intervention Trial;Kentucky;Leisures;Life;male;Malignant neoplasm of lung;Mediating;Mediator;Medical;Medical Oncology;Mental Health;Methods;Mind;Mission;National Cancer Institute;Normalcy;novel;Nurses;Occupational Therapist;Outcome;palliative;Palliative Care;Pathway interactions;Patient Care;patient population;Patients;Performance Status;Persons;Population;Poverty;Premature Mortality;primary outcome;psychological distress;Psychology;psychosocial;Psychosocial Assessment and Care;psychosocial outcome;Public Health;Quality of life;Randomized;randomized trial;reduce symptoms;Reporting;Research;residence;Resource-limited setting;response;Role;routine care;Rural;satisfaction;sex;skills;social;Social Functioning;Social Workers;socioeconomic disadvantage;Subgroup;survivorship;Telephone;Testing;theories;therapy design;Thinking;Toxic effect;treatment as usual;Treatment Efficacy;treatment response;Underserved Population;Universities;Update;Work

PROJECT_TITLE: Pathways, a Hope-Based Intervention to Support Personal Goal Pursuit, Mental Health, and Quality of Life during Advanced Lung Cancer Treatment


NIH_SPENDING_CATS: Complementary and Integrative Health;Kidney Disease;Nutrition;Obesity

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: NARRATIVE Rhythms in biological functions are coordinated by timing cues, such as feeding-fasting and sleep-wake cycles, intimately linking function, metabolism, and the molecular clock. Obesity is associated with enhanced cardiovascular disease risk and a loss in feeding-fasting cycles. The proposed studies will define potential causes for obesity-dependent kidney disease and how timing of food intake is beneficial.

PI_NAMEs: POLLOCK, DAVID M (contact);POLLOCK, JENNIFER S

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: Adhesions;antioxidant therapy;ARNTL gene;Bioenergetics;Biological Process;Blood Pressure;blood pressure control;Blood Vessels;Body Fluids;Cardiovascular Diseases;cardiovascular disorder risk;CD4 Positive T Lymphocytes;cell motility;Cell Physiology;Cells;Chronic Kidney Failure;circadian;circadian pacemaker;Circadian Rhythms;Consumption;Cues;cytokine;Data;design;Diet;diet-induced obesity;Diurnal Rhythm;Duct (organ) structure;Eating;Electrolytes;Endothelial Cells;Endothelin-1;Endothelium;Energy Intake;Energy Metabolism;Excretory function;Fasting;Fatty acid glycerol esters;feeding;Fibrosis;Fluid Balance;food restriction;Functional disorder;Genes;Glomerular Filtration Rate;Goals;Health;High Fat Diet;Homeostasis;Human;Hypoxia;immune activation;Impairment;improved;Inflammation;Inflammatory;Injury to Kidney;interstitial;Intervention;Investigation;Kidney;Kidney Diseases;kidney dysfunction;kidney fibrosis;kidney medulla;Knock-out;Knockout Mice;Link;Liquid substance;Mediating;Mediator;Metabolic;Metabolic dysfunction;Metabolism;migration;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Modeling;Molecular;molecular clock;mouse model;mRNA Expression;Mus;Nephrons;Nocturnal Hypertension;Obese Mice;Obesity;Oxidants;Oxidative Stress;Pathway interactions;Periodicity;Peripheral;Phase;Physiological;Production;Reactive Oxygen Species;reduced food intake;Regimen;renal damage;Respiration;restoration;Risk;Site;Sleep Wake Cycle;Small Intestines;T cell infiltration;T-Cell Activation;T-cell inflamed;T-Lymphocyte;Testing;Time;Time-restricted feeding;Tissues

PROJECT_TITLE: Timing of Diet and Kidney Pathophysiology in Diet-Induced Obesity

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Organ Transplantation;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Transplantation

ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Donor specific HLA antibodies (DSA) develop against short amino acid sequences (eplets) within the HLA antigen and lead to early graft loss in kidney transplant recipients. Identifying which mismatched eplets are most high-risk for DSA formation can help to avoid these in upcoming transplants and improve long-term allograft survival. This research will inform the development of a novel and adaptive allocation model aimed at reducing immunological burden, while optimizing racial and geographic equity, and ensuring optimal organ utilization.

PI_NAMEs: CHARNAYA, OLGA  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: access disparities;Address;Age;Algorithms;Allografting;Amino Acid Sequence;Antibodies;antibody detection;Antibody Formation;Antibody Response;Biometry;burden of illness;career;Characteristics;Child;Childhood;Chronic;Clinical;Clinical Data;clinical development;clinical practice;Clinical Research;cohort;Competence;Computer Models;Computer software;Conduct Clinical Trials;Data;Data Analyses;data management;design;Development;Dialysis procedure;dissemination science;Doctor of Philosophy;effective therapy;Elements;End stage renal failure;Ensure;Epitopes;Equity;Etiology;Failure;Genotype;geographic disparity;Geography;Goals;graft failure;Graft Survival;hazard;high risk;Histocompatibility Testing;HLA Antigens;Immune response;Immune system;Immunogenetics;immunogenicity;Immunologics;implementation science;improved;improved outcome;Incidence;Injury;Intervention;Kidney;Kidney Transplantation;Learning;Mediating;Modality;Modeling;Molecular;Morbidity - disease rate;Nature;novel;Organ;organ allocation;Organ Donor;organ procurement transplantation network;Organ Procurements;Outcome;Output;Policies;Public Health Schools;Race;racial disparity;Research;Research Design;Research Methodology;Research Personnel;Resolution;Retrospective Studies;Risk;Risk Factors;Risk Reduction;Site;skills;System;Techniques;Technology;Testing;Time;tool;Training;transplant centers;Transplant Recipients;Transplantation;Transplantation Immunology;Uncertainty;United States;Wait Time;Waiting Lists;Work

PROJECT_TITLE: Implementation of Eplet Mismatch Analysis in Pediatric Kidney Transplantation

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The routine use of race/ethnicity-based lung function reference equations biases medical care and perpetuates asthma disparities by masking genetic ancestry differences in lung function. While equations that use genetic ancestry, instead of race/ethnicity, more accurately predict lung function for populations disproportionately affected by asthma, whether genetic ancestry-informed lung function equations also better predict asthma- related outcomes remains understudied. We will use six large studies of Black and Hispanic/Latino individuals with and without asthma and build a new prospective cohort of re-contacted asthma case participants to evaluate genetic ancestry-informed equations for predicting asthma-related outcomes while disentangling the social and genetic determinants of genetic ancestry differences in lung function.

PI_NAMEs: WITONSKY, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Affect;Algorithms;analytical method;Area;Asthma;biomedical facility;Black American;Black race;Bone Marrow Transplantation;California;career development;Caring;Characteristics;Child;Childhood;Clinical;Clinical Investigator;Clinical Research;cohort;Data;Detection;Development;Development Plans;Diagnosis;Disease;Disparity;Educational workshop;Environmental Risk Factor;Equation;Equity;ethnic bias;Ethnic Origin;Ethnic Population;experience;Faculty;Foundations;Funding;Future;Genetic;Genetic Determinism;genetic epidemiology;Genetic Variation;genomic data;genomic locus;Goals;Health Disparities Research;Hispanic;Hospitals;Hypersensitivity;Immunology;improved;Individual;innovation;interest;Knowledge;Latino;Latino Population;Letters;lung basal segment;Lung Diseases;Measurement;Measures;Mediation;Medical;meetings;member;Mentors;Methods;Modeling;multi-ethnic;National Center for Advancing Translational Sciences;Neighborhoods;novel;Outcome;Participant;Patient Self-Report;pediatric department;Performance;Population;Precision Health;Predictive Analytics;Prognosis;programs;prospective;Prospective cohort;Prospective Studies;Public Health;pulmonary function;Questionnaires;Race;racial bias;racial discrimination;racial population;Recontacts;Research;research and development;Research Design;research facility;Research Support;San Francisco;Scholars Program;Severities;social;social determinants;social epidemiology;social factors;Socioeconomic Status;Structure;Symptoms;Testing;Training;Translational Research;Universities;Variant

PROJECT_TITLE: Improving Prediction of Asthma-related Outcomes with Genetic Ancestry-informed Lung Function Equations

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: BOSTON

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Multidrug resistance in bacteria poses a great threat to human health and is mostly spread by plasmids that maintain themselves in cells using negative feedback control systems. Feedback control is also common in the human body where compromised control causes a whole range of human disorders due to an inability to maintain constant conditions. In this grant we develop and apply mathematical theory and experimental methods to study the principles of feedback control, primarily as illustrated by plasmids.

PI_NAMEs: PAULSSON, JOHAN  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Address;Affect;Bacteria;Bacteriophage lambda;Behavior;Binding;Biological Assay;Biological Models;Biological Process;biological systems;Biology;Biotechnology;Cell Cycle;Cell division;Cell Separation;Cells;Cessation of life;chemical reaction;Chemicals;chromosome replication;Complex;Concentration measurement;cost;Creativeness;Disease;Disease Outbreaks;Event;experimental study;Failure;Feedback;Gene Expression;Generations;Genotype;Goals;Grant;Growth;Health;Home;Horizontal Gene Transfer;Hospitals;Human;Human body;Image;Individual;insight;Kinetics;Knowledge;Lac Operon;Libraries;life history;Maintenance;man;Maps;mathematical methods;mathematical theory;Mathematics;Measures;Medical;Methods;Microscopy;Modeling;Modification;Molecular;Molecular Biology;Molecular Machines;Multi-Drug Resistance;mutant;Mutation;Noise;novel;Pattern;Pharmaceutical Preparations;Phenotype;Plasmid Cloning Vector;Plasmids;Population;Process;Property;Randomized;Reaction;replicator;Reporter;Research Personnel;Resolution;segregation;single molecule;Source;Stochastic Processes;System;Temperature;Testing;theories;Time;tool;Visualization

PROJECT_TITLE: Limits and trade-offs of feedback control

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Microbiome;Neurodegenerative;Neurosciences;Parkinson's Disease

PHR: Project Narrative/ Relevance Gastrointestinal symptoms including nausea, dysphagia, constipation, and defecatory dysfunction are significant non-motor manifestations of Parkinson disease that impact quality of life. The degenerative changes in the brain that result from Parkinson disease are thought to originate from abnormal proteins absorbed in the gastrointestinal tract. Thus, by characterizing how those proteins in the lining of the stomach and intestines or changes in the brain centers and nerves are associated with gastrointestinal symptoms, the proposed studies will identify targets for treatment such as medications that neutralize the abnormal proteins or restore normal nerve functions.

PI_NAMEs: CAMILLERI, MICHAEL L. (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: absorption;Acceleration;Address;Age;Aging;alpha synuclein;Animal Model;Attention;Autonomic Dysfunction;Autonomic Pathways;basal forebrain;Biochemical;Braak's hypothesis;Brain;Brain Stem;Cell Nucleus;Central Nervous System;Cerebral cortex;Clinic;Clinical;Clinical Trials;Cognitive;cognitive impairment in Parkinson's;Colon;Constipation;Control Groups;Corpus striatum structure;Deglutition Disorders;density;design;Dopamine;Dopamine Receptor;dopamine transporter;dopaminergic neuron;dorsal motor nucleus;Duodenum;Educational workshop;Elderly;Enteral;Enteric Nervous System;Enteroendocrine Cell;fecal microbiome;Functional disorder;Future;Gastric Emptying;gastrointestinal;gastrointestinal function;gastrointestinal symptom;Gastrointestinal tract structure;Gastrointestinal Transit;gut microbiota;Gut Mucosa;gut-brain axis;Human;Image;Impaired cognition;improved;in vivo;Individual;Infectious Agent;Inflammation;Intervention;intestinal epithelium;Intestinal permeability;Intestines;Investigation;Literature;microbiome;Molecular;Motility;motility disorder;Motor;motor disorder;motor symptom;Mucous Membrane;multidisciplinary;Nausea;Nerve;Nerve Degeneration;Nervous System;neural;neural circuit;Neurodegenerative Disorders;Neurons;neurotoxic;occludin;Parkinson Disease;Pathologic;Pathway interactions;Patients;Permeability;Persons;Pharmaceutical Preparations;Phenotype;Physiological;Poison;preclinical study;Prevention;Process;prospective;Prospective cohort;protein misfolding;Proteins;Quality of life;Questionnaires;receptor density;receptor expression;Research Design;Role;Short-Term Memory;Sigmoid colon;single photon emission computed tomography;Small Intestines;Specificity;Squalamine;Stomach;Submucosa;Symptoms;synucleinopathy;Tight Junctions;Time;Tissues;transcriptome;Travel;United States National Institutes of Health;Vagus nerve structure

PROJECT_TITLE: Parkinson Disease Neural Circuitry and Gastrointestinal Pathobiology

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Microbiome;Pancreatic Cancer;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The tumor-associated microbiome regulates pancreatic cancer progression but the exact mechanisms via which bacteria regulate tumorigenesis is still unknown. The proposed work will (1) determine the influence of tumor-associated bacteria on pancreatic cancer cells, (2) determine their ability to activate and differentiate pancreatic stromal cells, and (3) characterize the mechanisms of pathogenicity unique to pancreatic cancer-associated bacteria. Knowledge gained from our proposed experiments will provide insight into therapeutic strategies for gut microbial modulation in treating pancreatic cancer.

PI_NAMEs: DALEY, DONNELE  (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Ablation;Acceleration;Active Learning;advanced disease;Advisory Committees;Antibiotics;Area;Bacteria;Basic Science;Biological Assay;Biological Models;Cancer Biology;cancer cell;cancer initiation;carcinogenesis;career development;Cell Communication;Cell Physiology;Cell Proliferation;Cells;Coculture Techniques;Combined Modality Therapy;Culture Techniques;cytokine;Cytometry;Data;Development;Development Plans;Diagnosis;Disease;Doctor of Philosophy;dysbiosis;Environment;Epithelial Cells;Epithelium;Event;experience;experimental study;Fibroblasts;Gastrointestinal tract structure;Gnotobiotic;Goals;gut bacteria;gut microbiome;Human;Hypoxia;Image;Immune;immune cell infiltrate;Immunity;Immunofluorescence Immunologic;Immunohistochemistry;Immunosuppression;Immunotherapy;improved;In Vitro;in vitro Model;in vivo;Inflammatory;Inflammatory Response;insight;interest;Knock-out;Knowledge;Label;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Mediating;Melanoma;member;Mentors;Metabolic;Microbe;microbial;Microbiology;microbiome;microbiome composition;Modeling;mouse model;Mus;neoplastic cell;novel;Organoids;Pancreas;Pancreatic Adenocarcinoma;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;pathogenic bacteria;Pathogenicity;Pathologic;Patients;Phenotype;Production;Proliferating;Proteobacteria;recruit;Research;Research Personnel;screening;Signal Transduction;single-cell RNA sequencing;Stromal Cells;survival outcome;System;Testing;Therapeutic;Time;TLR4 gene;Training;transcriptome sequencing;Transgenic Organisms;tumor;tumor growth;tumor microbiome;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-infiltrating immune cells;tumorigenesis;tumorigenic;Up-Regulation;Work

PROJECT_TITLE: Microbial Dysbiosis in Pancreatic Cancer Initiation and Progression

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Cancer;Clinical Research;Immunization;Immunotherapy;Lung;Lung Cancer;Prevention;Vaccine Related

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Among the approximately 50% of non-small cell lung cancer patients who have a charged HLA-B supertype allele, greater clinical activity of programmed cell death 1 (PD-1) inhibitors is seen when mutations generate peptides in which a wild type amino acid is substituted with an amino acid that has a charge opposite from the HLA-B binding pocket, presumably based on favorable binding. Utilizing specimens from our ongoing study of gene modified dendritic cells plus pembrolizumab, we propose to assess the ablity of these peptides to induce anti-tumor T cell responses in co-culture assays. We will also evaluate whether we would be able to pulse autologous dendritic cells with these peptides as a potential personalized immunotherapeutic approach.

PI_NAMEs: GARON, EDWARD B (contact);LIU, BIN

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Affinity;Agreement;Alleles;Amino Acid Substitution;Amino Acids;anti-tumor immune response;antigen binding;Antigen Presentation;Antigen-Presenting Cells;antigen-specific T cells;Antigens;Autologous Dendritic Cells;Automobile Driving;bak protein;Binding;Biological Assay;Biopsy;Blood;Cancer Etiology;Cancer Patient;cancer therapy;Cell Maturation;Cessation of life;Charge;Clinical;clinical investigation;Clinical Research;Clinical Trials;clinically relevant;Clone Cells;Coculture Techniques;comparison control;Computational algorithm;Data;dendritic cell vaccination;Dendritic Cell Vaccine;Dendritic Cells;Dissociation;Dose;Electrostatics;Evaluation;experimental study;Exposure to;Foundations;Frequencies;Future;Gene Modified;HLA Antigens;immune checkpoint blockade;Immune response;Immunotherapeutic agent;Immunotherapy;In Situ;in situ vaccination;In Vitro;in vivo;Incubated;Injections;innovation;Institution;interest;Lead;Malignant neoplasm of lung;Methods;Minority;Monitor;Mutation;neoantigens;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;Outcome;patient population;Patients;pembrolizumab;Peptides;phase I trial;Physiologic pulse;Positioning Attribute;prediction algorithm;programmed cell death protein 1;recruit;Research;response;Role;Specimen;T cell response;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;therapeutically effective;Time;Toxic effect;treatment strategy;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;United States;Vaccination;vaccination strategy;vaccine platform;Vaccine Therapy

PROJECT_TITLE: Evaluation of a therapeutic vaccination strategy with motif neoepitope peptide-pulsed autologous dendritic cells for non-small cell lung cancer patients harboring a charged HLA-B binding pocket.


ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Positron pathology motivation the bring spatial that Emission Tomography (PET) i s a powerful tool for understanding pharmacology, neurochemistry, and  in the living human brain. Brain-dedicated devices allow enhancing the system performance, a that led to the development of multiple brain-dedicated PET systems over the last decade, yet still best performing commercial one is the HRRT, a more than two-decade old technology. Here, we propose to  to the end-user a new generation commercial brain-dedicated PET system, UHB-PET, with ultra-high resolution of <0.8mm (2.4mm for HRRT) and an effective sensitivity of >31x that of HRRT, specifications will expand the scope of clinical and research PET applications in both neurology and neuro-oncology. .

PI_NAMEs: GONZALEZ MARTINEZ, ANTONIO ;NEHMEH, SADEK  (contact)

PROGRAM_OFFICER_NAME: KIM, BOKLYE

PROJECT_TERMS: 3-Dimensional;abeta deposition;Adopted;Algorithms;Alzheimer's Disease;Anesthesia procedures;Area;attenuation;Biochemical;Biochemical Pharmacology;Biological;Brain;Brain Diseases;Brain imaging;Brain region;brain research;Cell Nucleus;Characteristics;Clinical;Collaborations;Corpus striatum structure;Coupled;Dedications;Dementia;detector;Development;Devices;Diagnosis;Diagnostic;Diameter;Disease;Dopamine;Dose;Drug Monitoring;Early Diagnosis;Early treatment;Effectiveness;entorhinal cortex;Event;Evolution;Excision;Exhibits;Funding;Generations;Goals;Head;Hippocampus;Human;Image;image reconstruction;improved;Industrialization;instrumentation;kinetic model;Learning;Lesion;locus ceruleus structure;Long-Term Effects;Machine Learning;Magnetic Resonance Imaging;Marketing;Medicine;metabolic abnormality assessment;metabolic imaging;Methods;millimeter;Modeling;molecular imaging;Monitor;Monte Carlo Method;Motion;Motivation;nanomolar;Nervous System Disorder;neural network;neuro-oncology;neurochemistry;Neurologic;Neurology;Neurotransmitters;next generation;Noise;Norepinephrine;novel;Operative Surgical Procedures;Organ;Outcome;Parkinson Disease;Pathology;Patients;Pediatrics;Performance;Pharmacology;Physics;Positioning Attribute;Positron;Positron-Emission Tomography;Proteins;quantitative imaging;Radiation exposure;Radiation therapy;Radioactive;Research;Research Personnel;Resolution;Scanning;Shapes;Signal Transduction;solid state;Specific qualifier value;Structure;Substantia nigra structure;System;Technology;Time;tomography;tool;Tracer;Treatment outcome;treatment response;tumor;Tumor Burden;ultra high resolution;Work;X-Ray Computed Tomography

PROJECT_TITLE: Ultra-High Performance Brain-dedicated PET scanner for Neurology and Neuro-oncology imaging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-J(57)R]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: UNIVERSITY OF MINNESOTA’S (UMN) BUILDING INTERDISCIPLINARY RESEARCH CAREERS IN WOMEN’S HEALTH (BIRCWH) PROJECT NARRATIVE In this competitive renewal of the UMN’s BIRCWHresearchcareer development program, wehighlight our strong track record over the past 14 years of developing successful and highly productive Scholars and showcase the new and innovative elements we have added this cycle including a focus on: (1) health equity and antiracism; (2) community-engaged scholarship; and (3) academic leadership. These new innovative elements, along with our strong leadership team, rigorous evaluation plan, and highly interdisciplinary mentors will ensure that we continue to elevate the success of our program and our Scholars.

PI_NAMEs: ALLEN, SHARON S (contact);MARK, KRISTEN PATRICIA;THYAGARAJAN, BHARAT

PROGRAM_OFFICER_NAME: TIGNO, XENIA

PROJECT_TERMS: anti-racism;career;career development;clinical practice;Collaborations;Communities;Competence;Disease;Educational Curriculum;Educational workshop;Elements;Environment;Evaluation;experience;Faculty;Family;Fostering;Funding;gender difference;Goals;Grant;Health;health application;health difference;health equity;improved;innovation;Interdisciplinary Study;Knowledge;Leadership;life span;Manuscripts;Mentors;mid-career faculty;Minnesota;Pathway interactions;Policies;Positioning Attribute;Productivity;Program Development;programs;Public Health;Publications;Publishing;Research;Research Project Grants;Scholarship;Science;Scientific Advances and Accomplishments;sex;skills;symposium;Training;training opportunity;Translations;United States National Institutes of Health;Universities;Vision;Woman;Women's Health

PROJECT_TITLE: University of MN Building Interdisciplinary Research Careers in Women's Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-W(50)]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Aging;Genetics

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Narrative: The nucleus serves as the point of convergence for forces experienced by cells and responds by regulating transcription that drive changes in cell states. How endothelial nuclear integrity is affected by physical forces, such as blood flow remains incompletely understood, yet these effects likely contribute to the initiation and progression of vascular diseases. The proposed work will involve in-depth characterization of changes in aortic endothelial nuclei under disturbed/oscillatory flow and the role of the viscoelastic intermediate filament, vimentin, in protecting the endothelial nucleus from the deleterious effects of fluid flow.

PI_NAMEs: SALVADOR, JOCELYNDA  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Actins;Affect;Age;age related;age related changes;Aging;Aorta;Area;ATAC-seq;atheroprotective;Atomic Force Microscopy;Binding;Biophysics;Blood flow;Blood Vessels;career;Cell Line;Cell Nucleus;Cell surface;Cells;Chromatin;Chromatin Structure;Chromosome Structures;Complex;CRISPR/Cas technology;Cytoplasm;Cytoskeleton;Cytosol;Data;DNA Double Strand Break;Endothelial Cells;Endothelium;Epigenetic Process;Evaluation;Exhibits;experience;experimental study;Exposure to;Fibroblasts;fluid flow;Gamma-H2AX;Gene Expression Profile;Genetic Transcription;Geometry;Heart;hemodynamics;Histones;Homeostasis;In Vitro;in vivo;Individual;Institution;interest;Intermediate Filaments;Invaded;Kinetics;Knockout Mice;Lamins;large datasets;Link;live cell imaging;Maintenance;Mechanical Stress;mechanotransduction;migration;Molecular;Nuclear;Nuclear Envelope;Nuclear Pore;Nuclear Structure;Pathology;Periodicity;Phenotype;plectin;Post-Translational Protein Processing;Premature aging syndrome;prevent;Process;Protein Array;Proteins;Proteomics;Reporter;Research;resilience;Role;Shapes;shear stress;Signal Transduction;single-cell RNA sequencing;skills;Stress;Techniques;Testing;Training;transmission process;Trees;Validation;Vascular Diseases;Vimentin;viscoelasticity;Work

PROJECT_TITLE: Mechanosensing and Mechanotransduction in the Endothelial Nucleus


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW ORLEANS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative There is a critical need to determine sex/gender differences in cardiovascular, infectious and neurological diseases and related risk factors across the research spectrum to improve health, eliminate disparities and optimize health care. In order to most effectively tackle the significant problems in women’s health, including sex/gender differences, there needs to be a diverse workforce prepared to undertake interdisciplinary, collaborative research. To this end, the Tulane BIRCWH program will provide mentored career development for junior faculty to increase the number and diversity of highly trained independent investigators engaged in women’s health and sex/gender differences research in the fields of cardiovascular diseases (CVD), infectious diseases (ID), and neurosciences (NS) across the lifespan.

PI_NAMEs: KROUSEL-WOOD, MARIE  (contact)

PROJECT_TERMS: Address;Area;Awareness;base;Basic Science;Biology;Cardiovascular Diseases;career;career development;Clinical Research;Clinical Trials;collaborative environment;Communicable Diseases;Competence;cultural competence;Development Plans;Disease;Educational workshop;efficacy evaluation;Epidemiology;equity, diversity, and inclusion;Ethnic Origin;Evaluation;Exposure to;Faculty;Gender;gender difference;Genetic;Goals;Grant;health disparity;health science research;Health Services Research;improved;innovation;Interdisciplinary Study;Knowledge;Laboratories;Learning;life span;Medicine;Mentors;Modeling;Molecular;Neurosciences;Physicians;Population;Prevention;programs;Race;Research;Research Methodology;Research Personnel;Research Project Grants;Research Training;Science;Scientist;Self Efficacy;Series;sex;Sex Differences;skills;social health determinants;Strategic Planning;success;Training;United States National Institutes of Health;Woman;Women's Health;Writing

PROJECT_TITLE: Building Interdisciplinary Research Careers in Women's Health


NIH_SPENDING_CATS: Clinical Research;Health Services;Women's Health Research

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: There is an urgent need to train investigators with an understanding of how to conduct research to understand the sex/gender differences in basic disease mechanisms and to understand the heterogeneity of treatment effects by sex/gender in devices, drugs, and other treatments. By harnessing the incredible talent and leveraging the unique resources of the Tufts community, Dr. Freund and Dr. Jaffe have developed and further expanded the Tufts University BIRCWH Scholars Program. This tailored training program for Early Career Investigators focuses on sex and gender differences and women's health research and ensures the training of a cadre of investigators to become the future research leaders in this critical area.

PI_NAMEs: FREUND, KAREN  (contact);JAFFE, IRIS Z

PROJECT_TERMS: Address;Applications Grants;Appointment;Basic Science;cardiovascular health;career;Caring;Clinical;Clinical Research;Clinical Services;Disease;disorder prevention;early-career faculty;Faculty;Funding;gender difference;Goals;graduate school;health equity;Health Services Research;Heterogeneity;Interdisciplinary Study;Life Cycle Stages;Maternal Health;Mentors;Modeling;next generation;Nutritional Science;Outcome;Outcomes Research;Preparation;programs;recruit;Research;Research Personnel;Research Project Grants;Research Training;Scholars Program;Science;sex;Sex Differences;skill acquisition;Training;Translational Research;treatment effect;Universities;Woman;Women's Health

PROJECT_TITLE: Tufts BIRCWH Program


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Sleep Research;Substance Misuse

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECTIVE NARRATIVE Despite the opioid epidemic causing over 46,000 overdose deaths in 2018, opioids remain important drugs for treating acute pain after surgery, and consequently put surgical patients at risk for their myriad of side effects and for chronic opioid use. As recent studies have implicated opioid-induced sleep disturbances as a contributing factor to opioid dependence and relapse, the proposed studies aim to better understand the neurobiological mechanism by which opioids disrupt sleep acutely and chronically. Together, these new findings may offer a new approach in treating those suffering from opioid addiction, and new insights into the role of acute opioid use in sleep disturbances after surgery.

PI_NAMEs: LI, LI  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Acute;Acute Pain;Anesthetics;Arousal;awake;Behavior;behavior measurement;Brain;Brain region;calcium indicator;career;cell type;Cells;Chronic;Cognition;conditional knockout;Data;Data Analyses;Disease;Doctor of Philosophy;Dose;Drug Targeting;Drug usage;economic cost;Electroencephalography;Electromyography;Endoscopy;Equilibrium;Fiber;Foundations;Future;Glutamates;Goals;Image;in vivo;Injections;insight;locus ceruleus structure;LoxP-flanked allele;Machine Learning;Measures;Mediating;Mediator;Mental Depression;Mentors;Mentorship;Morphine;morphine administration;mouse model;mu opioid receptors;multidisciplinary;Mus;Naloxone;negative affect;neural circuit;neurobiological mechanism;Neurobiology;Neurons;Neuropharmacology;Norepinephrine;novel strategies;novel therapeutics;Operative Surgical Procedures;Opiate Addiction;Opioid;opioid epidemic;Opioid Receptor;opioid use;opioid use disorder;opioid withdrawal;optogenetics;overdose death;Oxymorphone;Pain Threshold;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacology;Phase;Photometry;Photons;Physicians;Postoperative Pain;receptor expression;receptor function;Relapse;Research Personnel;response;Risk;Role;Saline;sedative;sensor;side effect;skills;skills training;Sleep;Sleep disturbances;sleep pattern;Source;Substance abuse problem;Technical Expertise;Techniques;Testing;Thalamic structure;Time;tool;Training;United States;Universities;Virus;Washington;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Unraveling the Locus Coeruleus Circuitry in Opioidinduced Sleep Disturbances


NIH_SPENDING_CATS: Cancer;Women's Health Research

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The mission of the University of Wisconsin-Madison (UW) Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) program is to provide interdisciplinary career development for a diverse cohort of early career faculty (scholars) and foster their successful transition to independent funding in women’s health and sex/gender differences research. The UW BIRCWH will realize this goal by 1) providing career development opportunities aligned with national goals; 2) offering competency-based, mentored research training; 3) creating alliances with programs designed to support underrepresented faculty; and 4) pioneering new approaches to team science and career coaching. Each scholar will emerge equipped to lead a funded interdisciplinary team engaged in groundbreaking research that will positively impact women, families, and communities.

PI_NAMEs: BARROILHET, LISA M;BURNSIDE, ELIZABETH S (contact);STEEGE, LINSEY M

PROJECT_TERMS: Behavioral Research;Biomedical Research;career;career development;Climate;Clinical Research;Collaborations;collaborative environment;Competence;Dedications;design;Discipline;diversity and equity;early-career faculty;Educational Curriculum;Ensure;Environment;Ethnic Origin;Evolution;experience;faculty mentor;Feedback;Fostering;Foundations;fundamental research;Funding;Future;Gender;gender difference;Goals;improved;innovation;Interdisciplinary Study;Knowledge;Leadership;Mentors;next generation;novel;Outcome Measure;Process Measure;professor;Program Development;programs;Race;Research;Role;Scholars Program;Schools;Science;senior faculty;sex;Sex Orientation;skills;Training;translational pipeline;United States National Institutes of Health;Universities;Vision;Wisconsin;Woman;Women's Health

PROJECT_TITLE: University of Wisconsin Building Interdisciplinary Research Careers in Women's Health (BIRCWH) Scholars Program


ORG_CITY: GALVESTON

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: Project Narrative The UTMB BIRCWH program launches assistant professors into research careers in women’s health, studying health disparities, Hispanic health, aging, infectious diseases, and reproductive health to improve the health of women across the lifespan. We recruit early career investigators from diverse racial/ethnic backgrounds in a variety of disciplines; they are guided by senior faculty mentors with interdisciplinary expertise in clinical research, drug development, sociology, public health, nursing, infectious disease prevention, engineering, and many other disciplines. Our program’s goal is to increase the number of diverse and skilled researchers who collaborate across disciplines to improve the lives of women.

PI_NAMEs: BERENSON, ABBEY B (contact)

PROJECT_TERMS: Active Learning;Admission activity;Advisory Committees;Aging;Area;Attitude;Bioinformatics;Biometry;career;career development;Collaborations;college;Communicable Diseases;Competence;cost;Data;Development;Development Plans;disease disparity;drug development;Eligibility Determination;Ensure;Evaluation;experience;Faculty;Funding;Gender;Goals;Grant;Health;health disparity;Health Services Research;Hispanic;Hispanic-serving Institution;Individual;Institutional Review Boards;Instruction;Knowledge;Leadership;Manuscripts;Medicine;meetings;Mentors;Methodological Studies;Molecular Biology;Process;professor;programs;Public Health;Publications;Publishing;Recording of previous events;Records;recruit;Reproductive Health;Research;Research Personnel;Resources;Review Committee;Role;Scholars Program;Science;sex;skills;Students;System;Texas;Time;Training;Underrepresented Populations;Universities;Women's Health;Work;Writing

PROJECT_TITLE: UTMB Women's Health Research Scholars Program


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics

ORG_CITY: TAMPA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: Public Health Relevance Statement: Ocular surface disorders are among the most common reasons for a visit to an ophthalmologist in the world and are frequently due to abnormal growth and function of the corneal epithelial cells. The research proposed here will identify the molecular factors and pathways important for normal growth and function of corneal epithelial cells, and their deficiencies that lead to sight-threatening diseases such as pterygium and ocular surface squamous neoplasia that if untreated cause corneal blindness.

PI_NAMEs: SWAMYNATHAN, SHIVALINGAPPA KOTTUR (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Ablation;Address;Adult;Affect;Anterior;Apical;Awareness;Basal Cell;Behavior;Biological;Blindness;BMP6 gene;carcinogenesis;Cell Culture Techniques;Cell Cycle Progression;Cell Differentiation process;Cell division;Cell Physiology;Cell Proliferation;Cell Shape;Cells;cellular imaging;Chromatin;Columnar Cell;Conjunctival Pterygium;Cornea;Corneal Diseases;corneal epithelium;Couples;Data;Defect;Development;Disease;Epithelial Cell Proliferation;Epithelial Cells;Epithelium;Event;experimental study;Eye;Genes;Genetic;Genome Stability;Goals;Growth;healthcare burden;Homeostasis;Human;imaging system;innovation;Knowledge;Link;Maintenance;Mesenchymal;Mission;Mitotic spindle;Molecular;Molecular Target;morphogens;mouse genetics;mouse model;Mus;Natural regeneration;Nature;next generation sequencing;novel;Nucleotides;ocular surface;ocular surface disease;ocular surface squamous neoplasia;Ophthalmologist;Organism;Outcome;Pathway interactions;Play;Proliferating;public health relevance;Publications;Publishing;Radiation Induced DNA Damage;Regulatory Pathway;Reporter;Research;Rest;Role;Shapes;Signal Transduction;spatiotemporal;Stratification;Stratified Epithelium;Study models;Techniques;Testing;Tetanus Helper Peptide;Tissues;transcription factor;Transgenic Mice;translational potential;tumor;United States National Institutes of Health;Up-Regulation;Vision;Visit;Work

PROJECT_TITLE: Ocular Surface Functions of KLF4 and KLF5

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-W(02)M]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse;Women's Health Research

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: 8. Project Narrative Aligning with the 2019-23 Trans-NIH Plan for Women’s Health Research, the long-term objective of the UIC BIRCWH is to promote training and careers to develop a well-trained, diverse, and robust workforce to advance science for the health of women. Through evidence-based mentoring practices, innovative training strategies, and strong internal and external multidisciplinary collaborations, the UIC BIRCWH improves recruitment, retention, and advancement of women and URMs as scientists and academic leaders in interdisciplinary women’s health and sex/gender differences research.

PI_NAMEs: BUHIMSCHI, IRINA A;MAKI, PAULINE M (contact)

PROJECT_TERMS: Acceleration;Address;Bioinformatics;bridge program;career;career development;Collaborations;college;didactic education;Disease;Doctor of Philosophy;Educational Curriculum;evidence base;Experimental Designs;Faculty;Female;Fostering;fundamental research;Funding;Gender;Generations;Goals;Grant;Health;Health Sciences;Healthcare;improved;Institution;Interdisciplinary Study;Knowledge;knowledge translation;Leadership;Medicine;Mentors;Midwestern United States;Nature;novel;personalized medicine;Policies;Postdoctoral Fellow;Principal Investigator;Professional Competence;programs;Quality of life;recruit;Reproducibility;Research;Research Personnel;Science;sex;Strategic Planning;success;tool;Training;Underrepresented Minority;United States National Institutes of Health;Woman;Women's Health

PROJECT_TITLE: UIC Building Interdisciplinary Research Careers in Women's Health Program


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: NEUROLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE As humans age, spatial memory gradually declines among healthy adults and those affected by neurological conditions like Alzheimer's disease, resulting in decreased individual independence and quality of life. To eventually develop therapeutics that prevent disease in and rejuvenate the aging brain, it is necessary to first understand the molecular, cellular, and circuit-level neurobiological mechanisms that drive cognitive decline. The proposed study will identify novel molecular drivers of aging in medial entorhinal cortex (MEC), a brain region critical for spatial memory, by correlating age-mediated gene expression changes in MEC neurons with differences in MEC neural activity among young and aged mice.

PI_NAMEs: HERBER, CHARLOTTE SOPHIA (contact)

PROGRAM_OFFICER_NAME: THOMAS, CIBU PAUL

PROJECT_TERMS: Address;Adult;Affect;Age;age effect;age related;age related changes;age related decline;aged;Aging;aging brain;aging population;aging related;aging related disease;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;animal old age;Animals;Behavior;Behavioral;Brain;Brain Diseases;Brain region;Cells;Code;Cognition;cognitive ability;Computer Models;Coupling;Data Analyses;Data Collection;Data Set;Dementia;density;Deposition;Development;Disease;Disinhibition;Doctor of Philosophy;Dorsal;drivers of aging;Electrophysiology (science);empowerment;Ensure;entorhinal cortex;Environment;experience;experimental study;extracellular;flexibility;Frequencies;Functional disorder;functional status;Future;Gene Expression;Goals;Head;healthspan;healthy aging;Hippocampus;Human;Immunohistochemistry;Impaired cognition;Impairment;Individual;innovation;insight;Interneurons;juvenile animal;Learning;Linear Models;Link;Liquid substance;Location;Maps;Measures;Medial;Mediating;member;Memory;Memory impairment;Memory Loss;mild cognitive impairment;Molecular;molecular pathology;molecular scale;Mus;Nerve Degeneration;neural;neural circuit;neural correlate;neurobiological mechanism;Neurologic;neuromechanism;Neurons;novel;old mice;Pathologic;Pattern;Performance;Periodicity;Phase;Physicians;Population;Positioning Attribute;pre-clinical;predictive modeling;prevent;Primates;Property;Quality of life;quantification of aging;Recording of previous events;Rejuvenation;Research Personnel;Rewards;Risk Factors;Rodent;Rodent Model;Scientist;single nucleus RNA-sequencing;skills;spatial memory;Speed;Support System;Surface;System;Therapeutic;therapy development;Theta Rhythm;Time;Training;transcriptomics;Transgenic Organisms;virtual reality;virtual reality environment;water environment;Wild Type Mouse;Work

PROJECT_TITLE: From Molecules to Behavior: Understanding How Aging Impacts Entorhinal-based Navigation


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Substance Misuse

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: Project Narrative  Alcoholic liver disease leads to cirrhosis and liver failure and is one of the leading causes of deaths worldwide. This project will characterize the hepatic mitochondrial response to ethanol, specifically ethanol-induced mitochondrial depolarization (mtDepo) with subsequent swift increase in alcohol metabolism (SIAM), as well as the recovery of hepatic mitochondria after ethanol by repolarization and biogenesis. Furthermore, the project will determine the possible roles of the adenosine nucleotide translocator, the mitochondrial ATP synthase, uncoupling proteins, and mitochondrial permeability transition pores in producing proton leaks to cause mtDepo after ethanol.

PI_NAMEs: SAVOCA, MATTHEW  (contact)

PROJECT_TERMS: Accidents;Acetaldehyde;Acetates;Acute;Address;Adenosine;Alcohol abuse;Alcohol consumption;Alcohol dependence;alcohol response;Alcoholic Liver Diseases;Behavior Disorders;Biogenesis;Cardiovascular Diseases;Cause of Death;Cessation of life;Chronic;Cirrhosis;Confocal Microscopy;cost;cost estimate;Dangerousness;Development;Disease;DsRed;Dyes;Ethanol;Ethanol Metabolism;Event;extracellular;Fibrosis;Fluorescence;fluorophore;Genus Hippocampus;Health;Hepatic;Hepatocyte;Hour;In Vitro;in vivo;Individual;inhibitor;Knowledge;Label;Laboratories;Liver;Liver diseases;Liver Failure;Liver Fibrosis;liver inflammation;Liver Mitochondria;Malignant Neoplasms;Medical;Membrane Potentials;Mental disorders;Mentors;Metabolic;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial membrane;mitochondrial metabolism;mitochondrial permeability transition pore;Mitochondrial Proton-Translocating ATPases;Molecular;multiphoton microscopy;Mus;novel therapeutics;Nucleotides;oxidation;Oxygen Consumption;Oxygen saturation measurement;Pattern;Peptide Initiation Factors;Permeability;Persons;prevent;Process;Productivity;Proteins;Protons;Reactive Oxygen Species;Recovery;Research;respiratory;response;Risk;Role;Serum;SLC25A4 gene;Steatohepatitis;Time;UCP2 protein;United States;Workplace

PROJECT_TITLE: Hepatic Mitochondrial Respiratory Activation, Depolarization and Recovery After Acute Ethanol


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Genetics;Kidney Disease;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Urologic Diseases

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: NARRATIVE This is a proposal to study the formation of nephrons that maintain bodily fluid homeostasis through blood filtration, reabsorption of needed compounds, control of blood pressure, and production of urine for excretion. Our over-arching goal is to broadly understand how physiologically important cell-populations form from precursors in the developing kidney and use these insights to generate replicate cells in human stem cell- based models. A better understanding of the genes involved in nephron development will aid in developing new genetic diagnostic tools for patients with kidney disease and novel regenerative therapies to replace kidney function.

PI_NAMEs: LINDSTROM, NILS OLOF (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: absorption;Address;Adopted;Adult;Automobile Driving;beta catenin;Birth;Bladder;blood filtration;Blood flow;Blood Pressure;blood pressure control;Body Fluids;Cell Differentiation process;Cell Lineage;cell replacement therapy;Cell Separation;cell type;Cells;Childhood;Chromosome Mapping;Cleavage Under Targets and Release Using Nuclease;Clinical;Confusion;Congenital Abnormality;congenital anomalies of the kidney;Cues;Data;Death Rate;Defect;Development;Developmental Anatomy;diagnostic tool;Dialysis procedure;disease model;Distal;DNA;Dose;Drainage procedure;effective intervention;Embryo;End stage renal failure;Ensure;Etiology;Excretory function;experimental study;fetal;Fluid Balance;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Markers;Genetic Transcription;Goals;Human;human stem cell-derived;human stem cells;improved;In Vitro;in vitro Model;in vivo;induced pluripotent stem cell;Infant;insight;Kidney;Kidney Diseases;Life;Life Expectancy;Ligands;Link;Maps;Mediating;Molecular;molecular modeling;Mouse Strains;Mus;Mutate;Mutation;nephrogenesis;Nephrology;Nephrons;Newborn Infant;novel;novel therapeutics;Organ Transplantation;Organoids;Patients;Pattern;Physiological;Physiology;Population;practical application;Production;programs;Proteins;Protocols documentation;Publishing;regenerative therapy;Regulation;Renal function;Replacement Therapy;Series;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Signaling Protein;Sodium Chloride;solute;Specific qualifier value;stem cell model;stem cells;synthetic biology;System;Techniques;Testing;Therapeutic;Time;tool;transcription factor;Transcriptional Regulation;Urinary tract;Urine;Validation;Variant;Water;Work

PROJECT_TITLE: Establishing and Mimicking Patterning Mechanisms in the Distal Nephron Tubule and Kidney Organoid

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Women's Health Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative The areas of women’s health and sex differences research have long had an inadequate cadre of investigators with top quality training sufficient to make them competitive for limited research funding dollars. By using interdisciplinary training and excellent mentoring to develop the careers of the research leaders of tomorrow, we can address the most important, pressing questions in women's health and sex and gender differences. By equipping early career scientists to find the answers, we have every expectation that this grant will lead the way to tangible improvements in women's health in the United States.

PI_NAMEs: REGENSTEINER, JUDITH G. (contact);SANTORO, NANETTE F.

PROJECT_TERMS: Advisory Committees;Appointment;Bioinformatics;career;career development;Colorado;Complex;Educational Curriculum;Environment;evidence base;experience;Funding;Gender;Goals;Grant;Growth;health difference;improved;Individual;innovation;Institution;Interdisciplinary Study;K-Series Research Career Programs;Leadership;Learning;Medical;Medicine;Mentored Clinical Scientist Development Program;Mentors;Methods;programs;Publications;Publishing;Research;research and development;Research Design;research study;Scientist;sex;Sex Differences;skill acquisition;Talents;Time;tool;Training;Universities;Women's Health;Work

PROJECT_TITLE: The Colorado Building Interdisciplinary Research Careers in Women's Health Program


ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Narrative This project seeks to validate an interventional radiology approach to non-surgically deliver and retrieve implantable microdevices (IMDs) designed to rapidly test multiple drug responses directly within a live tumor in its native environment. This approach is less invasive and more practical compared to current surgical methods of IMD delivery, and provides a more comprehensive and direct assessment of drug response compared to current biomarker-based personalization strategies. If successful, it could enable clinicians to screen and optimize personalized cancer treatments in nearly all patients with solid tumors.

PI_NAMEs: BHAGAVATULA, SHARATH  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Adverse event;Affect;Anatomy;Animal Model;Animals;Antineoplastic Agents;Biological Markers;Biopsy;Breast;cancer imaging;Cancer Patient;cancer therapy;Cause of Death;Cell Death;Clinical;clinical translation;Clinical Trials;cohort;Complication;Custom;Data;Device Designs;Device Removal;Devices;Dose;Drug Combinations;Drug Evaluation;Drug Exposure;Drug toxicity;effective therapy;Effectiveness;Enrollment;Environment;Evaluation;Excision;Feasibility Studies;first-in-human;Future;Goals;Hemorrhage;Hindlimb;Human;image guided;Implant;implantation;improved;In Situ;Injury;innovation;Intervention;Interventional radiology;Liquid substance;method development;Methods;microdevice;miniaturized device;minimally invasive;Modeling;Morbidity - disease rate;mouse model;multiple omics;Needle biopsy procedure;next generation;novel;Oncology;Operative Surgical Procedures;Oryctolagus cuniculus;Outcome;Outpatients;Patients;personalized cancer therapy;personalized medicine;personalized strategies;Pharmaceutical Preparations;Pharmacotherapy;precision drugs;preclinical study;predicting response;Procedures;prototype;Radiology Specialty;Regional Anatomy;Reproducibility;Research;response;Retrieval;Risk;Safety;safety and feasibility;Serum Markers;Skin;Soft tissue sarcoma;Solid Neoplasm;Specimen;Structure;Surgical incisions;Techniques;Technology;Testing;Tissues;tool;treatment optimization;treatment strategy;tumor;Tumor Debulking;Tumor Tissue;Work

PROJECT_TITLE: Interventional method development for multiplexed personalized drug evaluation using implantable microdevices


NIH_SPENDING_CATS: Cancer;Hematology;Rare Diseases

ORG_CITY: PORTLAND

ORG_NAME: MAINEHEALTH

ORG_STATE: ME

PHR: Project Narrative The overall goal of this application is to change how multiple myeloma, an incurable blood cancer, is understood and treated. We will discover new forms of cancer drug resistance that are driven by fat cell- derived factors. Thus, we will expose new interventions to overcome drug resistance to improve survival and quality of life for myeloma patients and patients with other cancers that grow in the bone.

PI_NAMEs: CAMPBELL, HEATHER F (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: 3-Dimensional;Adipocytes;Adipose tissue;Automobile Driving;bone;Bone Marrow;cancer drug resistance;Cancer Model;Cell Culture Techniques;Cells;cytokine;Disease Progression;Drug resistance;Environment;experimental study;FABP4 gene;FABP5 gene;Fatty acid glycerol esters;fatty acid-binding proteins;Fatty Acids;Goals;Growth;Hematopoietic Neoplasms;high body mass index;improved;In Vitro;in vivo Model;Individual;Intervention;Lead;Link;Malignant Neoplasms;mouse model;Multiple Myeloma;Mus;Mutate;Nature;neoplastic cell;novel;novel therapeutics;Older Population;Patients;Plasma Cells;Proteins;Quality of life;Research;response;Risk;Role;scaffold;Signal Transduction;Silk;Soil;Source;Specialist;Testing;Tissue Engineering;tumor;tumor growth;tumor progression;Work

PROJECT_TITLE: Research Specialist Support for Defining the Roles of Bone Marrow Adipocytes and FABP4/5 Signaling in Multiple Myeloma


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Lymphatic Research;Neurosciences;Sleep Research;Stroke

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative for R01 application by Esposito  Circadian control of brain-peripheral immune response after stroke  The immune response to cerebral ischemia is a major contributor to neuroinflammation and brain damage while circadian rhythm and aging profoundly impact peripheral immune response in disease. Is it possible that circadian rhythm affects systemic immune response in stroke and if so, is it different in young and aged mice? Here, we propose that Astrocytic HO1 in active phase stroke (ZT13) amplifies endogenous anti-oxidative stress response in CLN, reduces splenic inflammation, and decreases brain endothelial inflammation, whereas in aged mice the brain to peripheral pathway might work differently. Addressing the cause of different response in aging vs young stroke subject might allow us to target specific pathways. This project should define new mechanisms that connect the immune response in stroke with circadian biology.

PI_NAMEs: ESPOSITO, ELGA  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: 4 hydroxynonenal;Address;Affect;Age;age effect;Aging;ARNTL gene;Astrocytes;Attenuated;awake;B-Lymphocytes;behavioral outcome;biological adaptation to stress;Biological Markers;Blood;Brain;brain cell;brain control;brain endothelial cell;Brain Injuries;C57BL/6 Mouse;Carnosine;CD8-Positive T-Lymphocytes;Cell Separation;Cells;Cerebral endothelium;Cerebral Ischemia;Cerebrospinal Fluid;Cervical lymph node group;circadian;circadian biology;circadian regulation;Circadian Rhythms;Coculture Techniques;CXCL10 gene;CXCR3 gene;cytokine;cytotoxic CD8 T cells;Data;deprivation;Disease;Drainage procedure;Etiology;Female;Flow Cytometry;Functional disorder;gain of function;Genes;Glucose;heme oxygenase-1;HMGB1 gene;Hypericin;Immune;Immune response;Immune system;Immunity;Immunomodulators;In Vitro;in vivo;Infarction;Inflammation;Injury;Ischemic Brain Injury;Knockout Mice;loss of function;Lymph Node Dissections;Lymph Node Drainage;lymph nodes;Lymphatic;lymphatic drainage;Lymphatic Endothelial Cells;Lymphatic Endothelium;Macrophage;male;Mediating;Microglia;Modeling;Mus;Nature;neuroinflammation;novel;old mice;Oxidative Stress;Oxygen;Pathway interactions;Patients;Peripheral;Phase;Plasma;post stroke;potential biomarker;Primary Cell Cultures;Publishing;Recombinants;response;Rodent;Signal Pathway;Signal Transduction;Sleep;Small Interfering RNA;spatiotemporal;Spleen;Standardization;Stroke;stroke model;T cell infiltration;T-Lymphocyte;targeted biomarker;Testing;Time;TLR4 gene;Validation;Work

PROJECT_TITLE: Circadian Control of Brain-peripheral Immune Response After Stroke

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Women's Health Research

ORG_CITY: Pittsburgh

ORG_NAME: MAGEE-WOMEN'S RES INST AND FOUNDATION

ORG_STATE: PA

PHR: PROJECT NARRATIVE Despite impressive scientific advances in recent years, the field of women’s health research continues to lag behind the forefront of scientific development. We propose to take advantage of the extraordinary academic environment at Magee-Womens Research Institute and the University of Pittsburgh’s Health Sciences and Engineering Schools to offer an exceptional interdisciplinary training program, across a woman’s lifespan, emphasizing inclusive and diverse personalized prevention, diagnostics, and therapeutics, designed to benefit all human communities.

PI_NAMEs: YANOWITZ, JUDITH L (contact)

PROJECT_TERMS: Advisory Committees;Ally;Basic Science;Biological;career;Career Choice;career development;Clinical;Clinical Sciences;Collaborations;Communities;community partnership;community-centered;design;Development Plans;Education;Engineering;Faculty;Fertilization;Foundations;Gender;Goals;health determinants;Health Sciences;Health Services;Heterogeneity;Imagination;Individual;innovation;Integrated Health Care Systems;Interdisciplinary Study;Latinx;life span;Medical center;member;Mentors;Modeling;Morals;novel;Persons;Population Heterogeneity;programs;Puerto Rico;Reproductive Sciences;Research;Research Institute;Research Personnel;Resources;Schools;sex;skills;social;synergism;Talents;Thinking;tool;Training;Translational Research;Underrepresented Minority;Universities;University Hospitals;Woman;Women's Health

PROJECT_TITLE: Building Interdisciplinary Research Careers in Women's Health in Pittsburgh


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: This work will provide critical scientific insight into a novel adaptive resistance mechanism to anti-PD-1 antibody immunotherapy in cancer. These proposed studies are designed to characterize the NLRP3 inflammasome as a therapeutic target and biomarker capable of enhancing the efficacy of anti-PD-1 antibody immunotherapy. Therefore, this approach promises to provide a previously unrecognized immunotherapeutic target that will expand the cancer patient population responding to checkpoint inhibitor immunotherapy as well as a biomarker allowing for improved patient selection and more optimal tailoring of immunotherapy regimens to specific cancer patients.

PI_NAMEs: HANKS, BRENT ALLEN (contact)

PROGRAM_OFFICER_NAME: BOURCIER, KATARZYNA

PROJECT_TERMS: adaptive immune response;Address;anti-PD-1;anti-PD1 antibodies;anti-PD1 therapy;antibody immunotherapy;Automobile Driving;base;Beds;Biological Markers;Cancer Patient;CD8-Positive T-Lymphocytes;Cells;checkpoint therapy;chemokine;Clinical;Clinical Protocols;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR screen;Cytotoxic T-Lymphocytes;Data;design;Development;DNA Sequence Alteration;effector T cell;gain of function;gain of function mutation;Gene Expression;Genetic;Genetic Markers;genome-wide;Goals;granulocyte;Harvest;Heat-Shock Proteins 70;Human;IL8RB gene;Immune checkpoint inhibitor;Immune Evasion;Immunotherapeutic agent;Immunotherapy;improved;in silico;In Vitro;in vivo;Inferior;Infiltration;Inflammasome;inhibitor;insight;Knock-in;Link;Malignant Neoplasms;marenostrin;Mediating;Melanoma;Melanoma patient;Modeling;Molecular;Mutation;Myelogenous;Myeloid-derived suppressor cells;neoplasm immunotherapy;neoplastic cell;novel;Oncology;Outcome;Pathway interactions;patient population;Patient Selection;PD-1 blockade;pharmacologic;Population;pre-clinical;Pre-Clinical Model;Process;programmed cell death ligand 1;Proteins;recruit;Regimen;Resistance;Resistance development;resistance mechanism;response;Role;Series;Signal Induction;Signal Pathway;Signal Transduction;small molecule;Specimen;T-Cell Activation;therapeutic biomarker;therapeutic target;Tissue Harvesting;Tissues;TLR4 gene;treatment strategy;tumor;Tumor Antigens;Tumor Tissue;Up-Regulation;Work

PROJECT_TITLE: Investigating the PD-L1:NLRP3 signaling axis as a tumor intrinsic mechanism of adaptive resistance to anti-PD-1 antibody immunotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


NIH_SPENDING_CATS: Bioengineering;Immunotherapy;Kidney Disease;Nanotechnology;Organ Transplantation;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PHR: NARRATIVE We have achieved in nonhuman primates and in initial clinical trials the induction of transient hematopoietic chimerism and long-term I.S.-free renal allograft survival, following combined MHC mismatched kidney and BM transplantation. The proposed research studies will evaluate novel conditioning modalities aimed at improving the consistency of tolerance induction as well as eliminating the genotoxic components from our current regimen, by using a unique mAb107 directed against the archetypal innate immune receptor CD11b, and ImmTOR, nanoparticles containing rapamycin, that potently modulate innate and adaptive immunity towards the allograft. Our preliminary studies indicate that these approaches will provide safer and more effective recipient conditioning, which will make this tolerance strategy available to many more transplant recipients. Our NHP model has been proven to provide strong correlations with subsequently observed outcomes in humans. Thus we anticipate that the results of these studies will be directly applicable to clinical trials.

PI_NAMEs: ARNAOUT, M. AMIN ;KAWAI, TATSUO  (contact)

PROGRAM_OFFICER_NAME: SHAW, JULIA M

PROJECT_TERMS: adaptive immune response;adaptive immunity;Adverse effects;Affect;Allogenic;Allograft Tolerance;Allografting;antagonist;Anti-CD40;Antigens;B-Lymphocytes;BCL2 gene;Bone Marrow;Bone Marrow Transplantation;Cells;chemotherapy;Chimerism;Clinical;Clinical Trials;comorbidity;conditioning;Dendritic Cells;Dose;Dual-role transvestism;Encapsulated;exosome;experimental study;extracellular vesicles;Failure;Family suidae;genotoxicity;Goals;Hematopoietic;hematopoietic engraftment;Hematopoietic stem cells;HLA Antigens;Human;Immune;Immunologic Receptors;Immunologics;immunoregulation;Immunosuppression;improved;In Vitro;in vivo;Inferior;Inflammatory;Inflammatory Response;Injury to Kidney;Innate Immune Response;Integrin Inhibition;Integrins;Investigation;irradiation;Ischemia;ITGAM gene;ITGB2 gene;Kidney;kidney allograft;Lead;living kidney donor;Maintenance;Methods;Modality;Modeling;Monoclonal Antibodies;mTOR Inhibitor;Mus;Myeloid Cells;nanoparticle;Natural Immunity;nonhuman primate;novel;Organ Transplantation;Outcome;Pathway interactions;patient population;Peripheral;preclinical study;Protocols documentation;Regimen;Reperfusion Injury;Reporting;research study;response;Role;Sirolimus;Solid;Surface;Testing;TNFSF5 gene;Transplant Recipients;Transplantation;Transplantation Tolerance;Warm Ischemia;Whole-Body Irradiation

PROJECT_TITLE: Targeting innate immunity for induction of robust renal allograft tolerance


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative HIV infection of microglial cells in the brain causes HIV-associated neurocognitive disorder and represents a viral reservoir that is a barrier to cure the infection. This study exploits a novel experimental model system where primary human microglial cells and immune cells are xenografted into mice and altered to carry a genetic reporter system to identify actively and latently HIV-infected cells. The system will illuminate at single cell resolution the transcriptomics, epigenomics, and 3D genomic state of the HIV infected cells in the brain in response to antiretroviral treatment and after treatment with latency reversal agents.

PI_NAMEs: AKBARIAN, SCHAHRAM ;CHEN, BENJAMIN K (contact);SWARTZ, TALIA H

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: 3-Dimensional;Acute;Adult;Affect;Aftercare;antiretroviral therapy;Architecture;Autopsy;Binding;Biological Markers;Biological Models;Blood;Brain;brain cell;Cell Culture System;Cell Culture Techniques;Cell Lineage;cell type;Cells;Central Nervous System;Chromatin;chromatin remodeling;Chromium;Complex;derepression;design;Disease;Dominant-Negative Mutation;Drug Modulation;DsRed;Encephalitis;Epigenetic Process;epigenomics;Experimental Models;Frequencies;Genetic;genetic approach;Genetic Engineering;Genome;Genome Mappings;Genomics;Goals;Histone H3;histone methyltransferase;Histones;HIV;HIV Infections;HIV-1;HIV-associated neurocognitive disorder;Human;human induced pluripotent stem cells;humanized mouse;Immune;Immune system;In Vitro;in vivo;Infection;Inflammation;innovation;integration site;Intervention;Kinetics;Life Cycle Stages;Link;Long Terminal Repeats;Lymphocyte;Lysine;Methionine;Methylation;Microglia;Molecular;Molecular Conformation;mouse model;Mus;Myelogenous;Myeloid Cells;Neurologic Symptoms;Neurons;novel;Organ;Pathogenicity;Peripheral;Persons;pharmacologic;Population;Productivity;Proviruses;Regimen;Reporter;Repression;Resolution;response;Retrotransposon;Retroviridae;SETDB1 gene;Shock;single-cell RNA sequencing;Site;Sorting;Spleen;Synapses;System;Techniques;Testing;tissue culture;transcriptome;transcriptomic profiling;transcriptomics;Transgenes;Viral;Viral reservoir;Virus;Virus Activation;Virus Diseases;Virus Integration;Virus Latency;Work;Xenograft procedure

PROJECT_TITLE: Cell-lineage specific epigenomic determinants of HIV latency in humanized mouse brain and blood


ED_INST_TYPE: SCH OF BUSINESS/PUBLIC ADMIN

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE This study will help document the influence of community programs and policies (CPPs) and the contextual food environment on diet. It will also determine whether differences by race/ethnicity and socio-economic status in the relationship between CPPs and diet persist once the contextual food environment is considered. The findings will help inform community investments to improve the diets of all children to address health disparities.

PI_NAMEs: COLABIANCHI, NATALIE  (contact)

PROGRAM_OFFICER_NAME: BROWN, ALISON GWENDOLYN MARY

PROJECT_TERMS: Address;Affect;African American;Ancillary Study;Area;Behavior;Behavioral;Beverages;Black race;Body mass index;Buffers;Businesses;Characteristics;Child;Communities;Community Developments;community intervention;community organizations;community setting;community-level factor;Consumption;contextual factors;cost effective;Data;Data Analyses;data integration;Data Set;density;Diet;dietary;Dietary Fiber;dietary guidelines;Dietary intake;Disparity;Effectiveness;Energy Intake;Ethnic Origin;Ethnic Population;Familiarity;fast food;Food;food consumption;food environment;fruits and vegetables;Future;Geography;good diet;Grant;Health;Health Benefit;health disparity;health inequalities;Healthy Eating;Heart Diseases;Hematological Disease;Hispanic;Home;Household;improved;Individual;Inequity;informant;Intake;Intercept;Intervention;Interview;Investments;Knowledge;Latino;Life;Link;Literature;Local Government;low socioeconomic status;Lung Diseases;Measures;Modeling;National Heart, Lung, and Blood Institute;Neighborhoods;novel;nutrition;Nutrition Policy;Nutritional;Outcome;Participant;Physical activity;Policies;programs;Race;racial difference;racial diversity;racial population;Reduce health disparities;Research;response;Restaurants;Role;Sampling;Schools;secondary analysis;Shapes;Sleep Disorders;Socioeconomic Status;Subgroup;sugar;Supermarket;sweetened beverage;Unhealthy Diet;United States;Weight

PROJECT_TITLE: The role of the contextual food environment and community programs and policies on diet and dietary disparities in the national Healthy Communities Study

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Prevention;Rare Diseases

PHR: Project Narrative: Intraductal papillary mucinous neoplasms (IPMN) of the pancreas are radiographically identifiable cystic precursor lesions of pancreatic cancer that evolve from low-grade dysplasia to high-grade dysplasia to carcinoma. Through the use of spatial transcriptomics, we have identified sub-type specific (intestinal vs. pancreaticobiliary) epithelial markers of high-grade dysplasia. In this proposal we utilize this novel technology to precisely identify sub-type specific markers of high- grade dysplasia; to incorporate these cyst fluid markers into a recently developed preoperative prediction model; and to validate this improved prediction model on two large clinical and cyst fluid repositories that have been created by our group.

PI_NAMEs: ALLEN, PETER J (contact)

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: arm;aspirate;assay development;Biological Assay;biomarker development;biomarker panel;biomarker validation;cancer invasiveness;Carcinoma;Characteristics;Chemoprevention;Clinical;Colloids;curative treatments;Cyst;Cyst Fluid;Cystic Neoplasm;Data;design;Development;Diagnostic;diagnostic accuracy;diagnostic value;differential expression;digital;Disease;disorder risk;Double-Blind Method;Duct (organ) structure;Dysplasia;Emotional;Epithelium;Evaluation;Excision;Financial cost;follow-up;Gene Expression;Genes;Goals;High grade dysplasia;high risk;Histologic;Imaging technology;improved;Inflammation;Intervention;Intestines;Laboratories;Lesion;Link;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Minority;Modeling;Moderate Dysplasia;Molecular;Morbidity - disease rate;mortality;Mucinous Neoplasm;new technology;Nomograms;novel;operation;Pancreatic Adenocarcinoma;Pancreatic Cyst;Pancreatic cystic neoplasia;pancreatic neoplasm;Papillary;Pathway interactions;Patient risk;Patients;Persons;Pilot Projects;Placebos;Population;predictive modeling;Prevention;Prevention trial;Prospective Studies;protein biomarkers;protein expression;Proteins;Proteomics;Publishing;radiological imaging;Randomized;repository;Resected;Resources;Risk;Sampling;Technology;Testing;Time;Tissues;transcriptome;transcriptomics;Validation;Work

PROJECT_TITLE: Biomarker validation for intraductal papillary mucinous neoplasms of the pancreas

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NOVATO

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

PHR: PROJECT NARRATIVE Protein translation in the dendrites of neurons is critical for the plasticity that encodes new memories. We propose to determine the effect of pathogenic dementia-causing tau on the protein translation in dendrites and the downstream postsynaptic protein dynamics that regulate the strength of neuronal connections. This research could reveal new ways to restore impaired plasticity and memory loss in Alzheimer’s disease and related dementias.

PI_NAMEs: TRACY, TARA  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;behavior test;Biology;Complex;Dementia;Dendrites;density;Disease;DLG4 gene;Electrophysiology (science);Eukaryotic Initiation Factors;Event;Foundations;Functional disorder;Glutamate Receptor;Goals;Hippocampus;Human;human induced pluripotent stem cells;Impaired cognition;Impairment;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;innovation;Knowledge;knowledge base;Label;Learning;Link;Long-Term Potentiation;Mass Spectrum Analysis;Mediating;Memory;Memory impairment;Memory Loss;Messenger RNA;Methods;Modeling;Molecular;Monitor;mouse model;mRNA Translation;Mus;Mutation;Neuronal Plasticity;Neurons;novel therapeutic intervention;Pathogenicity;patient derived induced pluripotent stem cells;Patients;Peptide Initiation Factors;Physiological Processes;polysome profiling;postsynaptic;Protein Biosynthesis;protein complex;Protein Dynamics;Proteins;Proteome;Proteomics;Puromycin;Quality of life;Regulation;Reporter;Research;response;Ribonucleoproteins;Role;Synapses;Synaptic plasticity;targeted treatment;tau interaction;tau mutation;tau Proteins;tau-1;Tauopathies;Therapeutic Intervention;therapeutic target;Time;trafficking;Transgenic Mice;Translating;Translation Initiation;Translations;translatome

PROJECT_TITLE: Impaired activity-dependent protein synthesis in dendrites and pathophysiology in tauopathy

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE This application for an R35 Leadership Award in ADRD research from Dr. Kristine Yaffe proposes to create an exciting multidisciplinary program entitled, the UCSF Population Based Research for Alzheimer's Innovation or Pop-BRAIN. Under Dr. Yaffe and the Co-Directors' leadership, the program will focus on groundbreaking research related to the exposome for ADRD, its effects over the life-course, and how these different exposures may influence health disparities in ADRD risk to offer new avenues for prevention. The program will also foster the careers of junior investigators from a variety of disciplines focused on population health for ADRD.

PI_NAMEs: YAFFE, KRISTINE  (contact)

PROGRAM_OFFICER_NAME: ELLIOTT, CERISE

PROJECT_TERMS: Achievement;Alzheimer's Disease;Alzheimer's disease related dementia;Award;Biological;Biometry;Caliber;cardiovascular risk factor;career;career development;cohort;Dedications;Development;Discipline;Disparate;Epidemiology;Ethnic Origin;Etiology;experience;Fostering;Funding;health disparity;Impaired cognition;improved;innovation;insight;Investigation;Lead;Leadership;Life Cycle Stages;Mentors;Mission;multidisciplinary;next generation;novel;Pathway interactions;Physical activity;population health;Population Heterogeneity;Population Research;Population Study;Positioning Attribute;pre-clinical;Precision Health;precision medicine;Prevention;Prevention strategy;programs;Public Health;Race;Research;Research Design;Research Personnel;Resources;Risk;Risk Factors;Scientific Inquiry;Seminal;sex;sleep quality;social health determinants;Training;Traumatic Brain Injury

PROJECT_TITLE: Population Based Research for Alzheimer's Innovation (POP BRAIN)