NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Diabetes;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: PEDIATRICS

PHR: Project Narrative The aims of this project are to establish a diverse cohort of youth at high-risk for type 2 diabetes (T2D), and to follow them longitudinally with 1) in-depth assessment of clinical, epigenetic and biochemical measures, as well as social determinants of health, and 2) survey for the emergence of T2D, in collaboration with a consortium of centers. This will allow us to gain new insights into disease risk and pathogenesis, and design precision intervention with the ultimate goal of prevention of youth-onset T2D, in accordance with NIH’s mission.

PI_NAMEs: BACHA, FIDA  (contact)

PROGRAM_OFFICER_NAME: BROADNEY, MIRANDA MARGUERITE

PROJECT_TERMS: 19 year old;abdominal fat;Adult;adverse childhood events;Age;Algorithms;Behavioral;Beta Cell;Biochemical;Black race;Body Composition;Body fat;Catecholamines;Cell Physiology;Child;Childhood;Clinical;clinical center;clinical phenotype;cohort;Collaborations;Collection;Communities;comorbidity;Complex;Conceptions;County;Deposition;design;Deterioration;Development;diabetes pathogenesis;Diagnosis;Disease;Disease Outcome;disease phenotype;disorder risk;DNA Methylation;Dual-Energy X-Ray Absorptiometry;Early identification;Enrollment;Ensure;Environmental Risk Factor;epigenetic marker;Epigenetic Process;epigenetic regulation;Equilibrium;ethnic diversity;ethnic minority;Evolution;Failure;Family;Fatty acid glycerol esters;federal poverty level;Functional disorder;Genetic;Gestational Diabetes;glucose tolerance;glycemic control;Goals;Gonadal Steroid Hormones;Growth and Development function;Growth Factor;health determinants;Health Insurance;Health Surveys;Hepatic;high risk;Hispanic;Hormonal;Hormones;Hydrocortisone;hypothalamic-pituitary-adrenal axis;improved;indexing;Individual;Inflammation;innovation;insight;Insulin Resistance;insulin secretion;insulin sensitivity;inter-individual variation;Intervention;Investigation;Knowledge;Latino;Longitudinal Surveys;Magnetic Resonance Imaging;maternal obesity;Measurement;Measures;Mediating;member;Metabolic;Methodology;Methylation;Mission;Modeling;multidisciplinary;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;Obesity;OGTT;Onset of illness;Organ;Pathogenesis;Pathway interactions;patient population;Pediatric Hospitals;peripheral blood;personalized intervention;Phenotype;Physiological;Population;Prediabetes syndrome;predicting response;prediction algorithm;predictive modeling;Predisposing Factor;Predisposition;Prevalence;prevent;Prevention;Process;progression risk;Puberty;puberty transition;racial minority;recruit;Research Design;Research Infrastructure;Research Personnel;Resources;Risk;Risk Factors;risk prediction;risk stratification;social;social factors;social health determinants;Standardization;stem;Stress;success;Surveys;Texas;treatment strategy;United States National Institutes of Health;urinary;Variant;Visceral fat;Youth

PROJECT_TITLE: Understanding and Targeting the Pathophysiology of Youth-onset Type 2 Diabetes-Texas Children's Center.


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: INDIANAPOLIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Experimental and clinical studies have demonstrated that chronic myocardial infarction is associated with adverse remodeling of the left atrium, which in turn has an adverse impact on left atrial function. Surprisingly, we have observed very high rates of cardiomyocyte cell cycle activity in the left atrium of infarcted mice. Here we propose to use a novel genetic model to determine the impact of atrial cardiomyocyte cell cycle activation on left atrial structural and functional remodeling following infarction, with the hope that the information gained from these studies may suggest interventions aimed at reversing compromised left atrial function following infarction.

PI_NAMEs: FIELD, LOREN J (contact);RUBART-VAN DER LOHE, MICHAEL

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: Acute myocardial infarction;Address;Adult;Anatomy;anillin;Apoptosis;Atrial Fibrillation;Atrial Function;Bacterial Artificial Chromosomes;Blood capillaries;Calcium;Cardiac Myocytes;CDK4 gene;CDKN2A gene;Cell Cycle;Cell Cycle Progression;Cell Nucleus;Cell Separation;Cells;Chronic;Clinical Research;Complex;Coronary;Coronary artery;Cytokinesis;Data;density;Development;Dilatation - action;Echocardiography;Electrophysiology (science);event cycle;Exhibits;experimental study;Fibrosis;Frequencies;Functional disorder;Genetic Models;Harvest;Heart;Heart Atrium;heart function;hemodynamics;Human;Hypertrophy;Image;imaging system;immune cell infiltrate;Individual;Infarction;Infiltration;inhibitor;Injury;insight;interstitial cell;Intervention;Kinetics;Laboratories;Laser Scanning Microscopy;Left;Left Atrial Function;Left atrial structure;Ligation;Location;Maps;mature animal;Mechanics;Mediating;Mitosis;Modeling;Molecular;mortality;mouse model;Mus;Myocardial;Myocardial Infarction;Myocardium;nerve supply;new therapeutic target;novel;Optics;Organ;Pathologic;Patients;Phosphotransferases;Play;postnatal;Predisposition;prevent;Process;Rattus;Reporter;Reporting;response;Rodent;Role;S phase;Secondary to;sham surgery;Shortening Fraction;Surface;System;Testing;Therapeutic Intervention;Tissues;transcriptome;transgene expression;Transgenes;Transgenic Mice;two-photon;Vascularization;Ventricular;voltage;Whole Organism;Wild Type Mouse

PROJECT_TITLE: Impact of cardiomyocyte cell cycle activity on atrial structural and functional remodeling following myocardial infarction

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Prevention;Social Determinants of Health

ORG_CITY: Aurora

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE  The overall goal of our proposed research is to understand why having health care coverage (or eligibility for health care coverage) is not sufficient to allow equal access to elective surgical care; despite successful efforts to expand coverage through Medicaid expansion and the Affordable Care Act (ACA), potentially elective surgical care is often not addressed until it becomes an emergency, particularly for vulnerable populations. We will use a multiphase mixed method approach to 1) identify modifiable factors for emergent presentation and explore the trajectory of progression to elective versus emergency surgery using billing data and EHR in a convergent mixed-methods design, combining quantitative variables with qualitative narrative data, 2) identify and quantify additional modifiable factors from the patient perspective that are not available in clinical or administrative datasets using an exploratory sequential design, using identified domains to conduct systematic review and meta-analysis for quantitative data, and 3) determine which modifiable factor or factors identified will have the greatest impact for future intervention strategies using Markov modeling. With this data we can model and understand what influences the persistent disparity in the ability to access elective surgical care despite increased coverage, and predict which factors contribute the most to the disparities and thus hold potential for the greatest impact.

PI_NAMEs: VELOPULOS, CATHERINE GARRISON (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: Acute;acute care;Admission activity;Affordable Care Act;American;Appointment;Area;billing data;biopsychosocial;Caring;Categories;Cholecystectomy;Chronic Disease;Classification;Clinical;Communication;Confusion;Consultations;cost;Country;Data;Data Analyses;Data Collection;data modeling;Data Set;demographics;design;Diagnosis;disability;Disease;Disease Progression;Disparity;Early Intervention;effective intervention;Eligibility Determination;Emergency department visit;Emergency Situation;Event;expectation;experience;Fright;Future;Goals;Health;Health Services Accessibility;Healthcare;Healthcare Systems;Hospitalization;Income;innovation;Insurance;Insurance Coverage;interest;International;Intervention;Interview;Language;Link;Manuals;markov model;Medicaid;Meta-Analysis;Methods;Modeling;Morbidity - disease rate;mortality;multiple data sources;novel;operation;Operative Surgical Procedures;Outcome;Pain;Pathologic;Patients;Persons;Phase;Population;prevent;Primary Care;Privatization;Probability;Procedures;prospective;Race;Recording of previous events;Research;Research Methodology;Research Personnel;Risk;Schedule;Services;social factors;social vulnerability;Social Work;Spanish;Structure;surgical disparities;surgical service;systematic review;Time;Transportation;Trauma;United States;Vulnerable Populations;World Health Organization

PROJECT_TITLE: Modifiable factors in emergent presentation of potentially elective general surgical disease for patients who are insured or insurance-eligible

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Genetics;Maternal Health;Pregnancy;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Gestational diabetes (GDM) is a public health problem because it increases pregnancy-related adverse outcomes and long-term health risks for both a mother and her offspring. Our proposal investigates how insulin-producing pancreatic β-cells normally adapt to pregnancy, and how these processes are defective in GDM. This work has potential to reveal fundamental mechanisms of how β-cells dynamically respond to changing insulin demands following specific metabolic stressors, and to identify new strategies to expand β-cells for therapeutic purposes in all types of diabetes.

PI_NAMEs: BANERJEE, RONADIP RALPH (contact)

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: Adult;adverse outcome;Affect;Appearance;ATAC-seq;Beta Cell;Binding;Bioinformatics;Biological Models;Birth;Bromodeoxyuridine;Cell Physiology;Cell Proliferation;Cell Survival;Cells;ChIP-seq;Chromatin;Complex;Confocal Microscopy;Data;Defect;Diabetes Mellitus;differential expression;Enzymes;Female;FOXM1 gene;Gene Expression;Gene Expression Profile;Genes;Genetic Models;Genetic Transcription;genomic locus;Gestational Diabetes;Goals;Grant;Health;Heterogeneity;Human;Hyperglycemia;Immunofluorescence Microscopy;Individual;Insulin;Investigation;islet;Knowledge;Label;Metabolic;Mothers;mouse genetics;mouse model;Mus;novel;novel strategies;Nutritional;offspring;overexpression;Pathway interactions;Peptides;Physiologic pulse;Physiological;Polycomb;Population Dynamics;post pregnancy;Postpartum Period;Pregnancy;Pregnancy Outcome;pregnant;Process;programs;Prolactin;Prolactin Receptor;Proliferating;Proliferation Marker;Public Health;Receptor Activation;Receptor Signaling;Regulation;Research;Resolution;response;Risk;Role;Serotonin;Signal Transduction;single-cell RNA sequencing;Specificity;Stress;stressor;Structure of beta Cell of islet;Testing;Therapeutic;Time;transcription factor;Transcriptional Regulation;transcriptome sequencing;Transducers;Work

PROJECT_TITLE: Pregnancy-Specific Mechanisms Regulating Beta-Cell Proliferation and Mass

STUDY_SECTION: CADO

STUDY_SECTION_NAME: Cellular Aspects of Diabetes and Obesity Study Section[CADO]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: AMHERST

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: Project Narrative The applicability of polymer-based drug delivery systems (DDSs) has been significantly restricted by critical technological challenges, such as the undesired immunogenicity of polyethylene glycol (PEG) broadly used in DDSs, the lack of PEG alternatives with optimal comprehensive properties, the scarcity of clinically valid DDSs for combination therapy, and the deficient understanding on topological effects of polymer scaffolds. To address these challenges, we aim to develop multifunctional biodegradable zwitterionic polymer-drug conjugates (ZPDCs) as novel PEG-free multidrug co-delivery systems with favorable biomedically relevant properties. A library of ZPDCs with different main-chain topology and other structural features will be prepared and their structure-dependent biointerface properties will be systematically investigated through biochemical, cellular and in vivo studies.

PI_NAMEs: CHENG, CHONG  (contact)

PROGRAM_OFFICER_NAME: RUSSELL, LUISA MARIE

PROJECT_TERMS: Address;Alkenes;Alkynes;Azides;Behavior;beta-Hydroxybutyrate;Biochemical;Biocompatible Materials;Biodistribution;Biological Assay;biological systems;biomaterial compatibility;Blood Circulation;Blood Circulation Time;cancer therapy;cell type;Cells;Chemistry;Circulation;Clinical;clinical application;clinical efficacy;Clinical Treatment;Combined Modality Therapy;Comparative Study;cyanine;cytotoxicity;design;design,build,test;Development;Disease;Drug Delivery Systems;Drug Kinetics;Dyes;Encapsulated;Environment;Esters;Evaluation;Exhibits;FDA approved;Foundations;gemcitabine;global health;Goals;Guidelines;hydrophilicity;Hydrophobicity;Image;imaging agent;Immune response;Immunocompetent;immunogenicity;In Vitro;in vivo;insight;Libraries;Ligands;Link;Malignant neoplasm of pancreas;Measurement;Methodology;Methods;Modeling;mouse model;multidisciplinary;Mus;nanotherapeutic;novel;Outcome;Paclitaxel;pancreatic cancer patients;Peptides;Periodicity;Pharmaceutical Preparations;plectin;poly(lactide);Polyesters;Polyethylene Glycols;polymerization;Polymers;Property;prototype;Publishing;Research;Research Activity;scaffold;Series;side effect;Solid;Structure;System;targeted agent;Technology;technology platform;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;Time;Toxic effect;Treatment Efficacy;uptake;Vertebral column;Work;Xenograft procedure

PROJECT_TITLE: Multifunctional Biodegradable Zwitterionic Polymer-Drug Conjugates for Multidrug Co-Delivery

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Mental Health;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: This study will elucidate how sleep, vascular disease risk factors, nocturnal hypertension and cognition/brain health inter-relate in both men and women of diverse ethnic backgrounds. Thus, we will hope to identify important factors that influence individual susceptibility in age-related declines in cognition that serve as targets (sleep quality, sleep apnea, nocturnal blood pressure) for mitigating risk for developing Alzheimer's Disease and its devastating effects on cognition, independence and well-being.

PI_NAMEs: PURCELL, SHAUN M;REDLINE, SUSAN S. (contact)

PROGRAM_OFFICER_NAME: FENG, LI REBEKAH

PROJECT_TERMS: abeta accumulation;abeta deposition;Acceleration;actigraphy;Address;age related;age related changes;Age-associated memory impairment;aged;Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Ambulatory Blood Pressure Monitoring;American;arterial stiffness;Biological Markers;Blood Pressure;blood pressure variability;Blood Vessels;Brain;brain based;brain health;Brain imaging;brain magnetic resonance imaging;cardiometabolism;cardiovascular disorder risk;Cerebral small vessel disease;Cerebrovascular Disorders;Cerebrum;circadian;Circadian Dysregulation;Circadian Rhythms;Cognition;Cognitive;Cognitive aging;cognitive change;cognitive performance;critical period;Data;Data Collection;Data Set;Dementia;dementia risk;Disease;Disease Marker;Disease susceptibility;Electroencephalography;Environmental Risk Factor;ethnic difference;ethnic diversity;Ethnic Origin;Etiology;Evolution;Family;Gender;Genetic;Health;Health Care Costs;Hippocampus;Hour;human old age (65+);Hypoxia;imaging biomarker;imaging study;Impaired cognition;Incidence;Individual;Individual Differences;inter-individual variation;Intervention;Knowledge;late life;lifestyle factors;Link;Literature;Longitudinal cohort;Magnetic Resonance Imaging;Measurement;Measures;Mediating;Mediator;men;metabolic phenotype;middle age;mild cognitive impairment;Morbidity - disease rate;Multi-Ethnic Study of Atherosclerosis;Multiomic Data;Nerve Degeneration;Neurocognitive;Neurons;neuropsychiatry;Nocturnal Hypertension;novel;Outcome;Participant;Pathologic;Pathway interactions;Pattern;Perfusion;Personal Satisfaction;Persons;Phenotype;Physiology;Pittsburgh Compound-B;Polysomnography;Population;Positron-Emission Tomography;Predisposition;Prevalence;Process;Public Health;Race;racial difference;recruit;Research;Risk;Risk Factors;risk mitigation;risk stratification;Role;Sampling;Sex Differences;Sleep;Sleep Apnea Syndromes;Sleep disturbances;sleep health;sleep physiology;sleep quality;Source;tau Proteins;temporal measurement;Thinness;Time;uptake;Vascular Diseases;vascular risk factor;White Matter Disease;Woman;β-amyloid burden

PROJECT_TITLE: Longitudinal Relationships Among Sleep, Cognition and Alzheimer's Disease Biomarkers: Discerning Causal Associations, Mediators and Susceptibility


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: White matter damage is a major factor underlying cognitive impairment in both cerebrovascular diseases and Alzheimer’s disease, but the factors mediating the damage have not been fully established. The studies will investigate the role of ApoE4 in the damage to the white matter. The findings deriving from the proposed study will advance our knowledge of the factors causing white matter injury and will suggest new putative therapeutic targets to counteract the devastating cognitive impact of white matter damage.

PI_NAMEs: IADECOLA, COSTANTINO  (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Abbreviations;Age-associated memory impairment;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Astrocytes;autocrine;Automobile Driving;base;Bilateral;Blood brain barrier dysfunction;Blood flow;Blood Vessels;blood-brain barrier disruption;blood-brain barrier permeabilization;Bone Marrow;Brain;Brain Hypoxia-Ischemia;Carotid Stenosis;Carrier Proteins;Cell secretion;Cells;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;cerebrovascular reactivity;Cerebrum;Chimera organism;Cognitive;cognitive function;cognitive testing;Consensus;Corpus Callosum;Dementia;Development;Dichloromethylene Diphosphonate;Endowment;Enzymes;Exhibits;experimental study;Female;Fluorescence;Functional disorder;Gene Targeting;Genetic;genetic risk factor;genetic variant;Histopathology;Human;Hypoxia;Image;Impaired cognition;Individual;Inflammation;Inflammatory;insight;International;ischemic injury;Knowledge;LDL-Receptor Related Protein 1;Leptomeninges;Lesion;lipid transport;Macrophage;Macrophage Activation;male;Mediating;Modeling;Molecular;mouse model;Mus;Myelogenous;Myeloid Cells;neocortical;neurovascular;neurovascular injury;new therapeutic target;novel;novel strategies;old mice;Oxidative Stress;Penetration;Perfusion;Photons;Play;Predisposition;Production;Reactive Oxygen Species;receptor;Regulation;Risk;Risk Factors;Role;sex;Source;Testing;therapeutic target;United States National Institutes of Health;Variant;Vascular Cognitive Impairment;vascular cognitive impairment and dementia;Vascular Diseases;vascular factor;Ventricular;white matter;white matter damage;White Matter Disease;white matter injury;Work

PROJECT_TITLE: ApoE4, Neurovascular Injury and Cognitive Impairment

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Behavioral and Social Science;Brain Disorders;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Health Services;Neurodegenerative;Neurosciences;Nutrition;Palliative Care;Rare Diseases

ORG_CITY: Charlestown

ORG_NAME: MGH INSTITUTE OF HEALTH PROFESSIONS

PHR: Project Narrative  As many as 92% of patients diagnosed with ALS are faced with the decision to have a feeding tube placed or to continue eating as their primary source of nutrition despite difficulty swallowing. At present, we lack an understanding of patient and caregiver goals and concerns surrounding this decision, and practice patterns surrounding feeding tube placement are highly variable. The primary objective of the proposed study is to develop and test a shared decision- making tool (i.e. decision aid) that improves patients’ knowledge about the decision, addresses patients’ goals and concerns surrounding the decision, and improves patient and healthcare provider communication throughout the decision-making process.

PI_NAMEs: PERRY, BRIDGET J (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Address;Affect;American;Amyotrophic Lateral Sclerosis;Area;Aspiration Pneumonia;Benefits and Risks;Caregivers;Client satisfaction;Clinic Visits;Clinical;Clinical Management;Clinical Medicine;clinical practice;Collaborations;Communication;Conflict (Psychology);debilitating symptom;Decision Aid;Decision Making;Deglutition;Deglutition Disorders;Development;Diagnosis;Disease;Eating;Effectiveness;Enteral Feeding;Environment;expectation;feasibility testing;Florida;General Hospitals;Goals;health care quality;Health Occupations;Health Personnel;Heterogeneity;Hospitals;Impairment;improved;Institute of Medicine (U.S.);International;Knowledge;Life;life span;Link;Malnutrition;Massachusetts;Mentors;Methodology;Methods;multidisciplinary;Neuromuscular Diseases;nutrition;Participant;Patient Care;patient oriented;Patient Preferences;Patient-Centered Care;patient-clinician communication;Patients;Pattern;personalized decision;Persons;Physicians;Population;preference;Process;prognostic;prototype;Provider;provider communication;Quality of life;Recommendation;Reporting;Research;Research Methodology;Research Personnel;Risk Management;Schedule;shared decision making;skills;Source;Structure;Surveys;Testing;Time;tool;Training;treatment choice;treatment planning;Uncertainty;Universities;user centered design;web based decision aid;Work

PROJECT_TITLE: Improving Shared Decision-Making Surrounding Dysphagia Management for Persons Diagnosed with Amyotrophic Lateral Sclerosis

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Cardiovascular;Complementary and Integrative Health;Dietary Supplements;Heart Disease;Heart Disease - Coronary Heart Disease;Nutrition

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PI_NAMEs: O'CONNELL, TIMOTHY D (contact);SHEARER, GREGORY C

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Acute myocardial infarction;Adult;Affect;Agonist;Antiinflammatory Effect;aorta constriction;Attenuated;Cardiac;Cardiac Myocytes;cardioprotection;Cardiovascular Diseases;Cell Death;chemokine;Chemotaxis;Clinical;cohort;coronary fibrosis;Coronary heart disease;cytokine;Data;Dependence;Diet;Disease Outcome;Dose;Eicosapentaenoic Acid;experimental study;Fatty Acids;Fibroblasts;Fibrosis;Functional disorder;G-Protein-Coupled Receptors;Genes;Genetic Polymorphism;Heart;Heart failure;Heart Injuries;Homeostasis;Human;Hypoxia;immune cell infiltrate;Immune response;improved;improved outcome;In Vitro;Incidence;Infarction;Inflammatory;interstitial;Ischemia;ischemic injury;long chain fatty acid;Macrophage;Measures;Mediating;Metabolic Diseases;Morbidity - disease rate;mortality;Mus;Muscle Cells;Myocardial Infarction;Myocardial Ischemia;Nonesterified Fatty Acids;novel;Nutrient;offspring;Omega-3 Fatty Acids;Outcome;Pathologic;Patients;percutaneous coronary intervention;Phospholipase A2;Polyunsaturated Fatty Acids;pressure;prevent;Production;receptor;receptor function;recruit;Reperfusion Injury;Reperfusion Therapy;Reporting;Role;sensor;Signal Transduction;Signaling Molecule;Single Nucleotide Polymorphism;Supplementation;Testing;Therapeutic;therapeutic target;Wild Type Mouse

PROJECT_TITLE: Free fatty acid receptor 4 cardioprotective effects in cardiac ischemic injury

STUDY_SECTION: MIM

STUDY_SECTION_NAME: Myocardial Ischemia and Metabolism Study Section[MIM]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Obesity

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Metabolic disease and insulin resistance are consequences of the expanding global obesity epidemic, and are associated with extensive microvascular and macrovascular morbidity and mortality. Hypertriglyceridemia, a prominent feature of insulin resistance, is a source of excess cardiovascular risk particularly among patients with type 2 diabetes; however, current treatments for hypertriglyceridemia have been inadequate to reduce this excess cardiovascular risk. These studies in rodents and humans will identify subgroups of insulin resistance that drive hepatic triglyceride production by separate mechanisms, allowing for the development of more effective, targeted therapies for the dyslipidemia of insulin resistance.

PI_NAMEs: VATNER, DANIEL  (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Acceleration;acipimox;ADD-1 protein;Address;Adipose tissue;Affect;Attenuated;Automobile Driving;Blood Vessels;Carbohydrates;cardiovascular risk factor;chromatin immunoprecipitation;Clinical;clinical heterogeneity;clinical practice;Development;diabetic patient;Diet;Disease;disease heterogeneity;Disease Resistance;Dyslipidemias;Esterification;Esterified Fatty Acids;Exercise;exercise intervention;Exhibits;Fasting;Fatty Acids;Fibrates;Fish Oils;Functional disorder;Future;Glucose;glucose metabolism;Glycerol;Goals;Hepatic;Heterogeneity;High Fat Diet;Human;human subject;Hypertriglyceridemia;IGF1 gene;Impairment;individual patient;individualized medicine;inhibitor;insight;Insulin;Insulin Receptor;insulin regulation;Insulin Resistance;insulin sensitivity;insulin signaling;interest;Intervention;Investigation;Knockout Mice;knowledge base;lipid biosynthesis;Lipids;Lipolysis;Liver;Measures;Metabolic;Metabolic Diseases;Metabolic Pathway;Modeling;Molecular;Molecular Biology;Morbidity - disease rate;mortality;mouse model;Mus;Muscle;Mutant Strains Mice;Mutation;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;obese patients;Obesity Epidemic;Pathogenesis;Pathology;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphotransferases;Physiological;Plasma;Play;precision medicine;Production;Proteins;Regulation;Resistance;response;Rodent;Rodent Model;Role;Signal Transduction;Skeletal Muscle;Source;stable isotope;Subgroup;targeted treatment;Techniques;Therapeutic;Tissues;tool;Tracer;transcriptome sequencing;transcriptomics;Translating;treatment optimization;Triglycerides;Western Blotting;Work

PROJECT_TITLE: Metabolic heterogeneity underlying hypertriglyceridemia in insulin resistance

STUDY_SECTION: IPOD

STUDY_SECTION_NAME: Integrative Physiology of Obesity and Diabetes Study Section[IPOD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: PROJECT NARRATIVE We propose that the pathogenesis and disease advancement of melanoma requires signaling networks that evade detection of immune cells. Specifically, our studies will address the driving factors such as CD47 behind the promotion of melanoma tumor cells from primary to metastatic stage.

PI_NAMEs: BOIKO, ALEXANDER D (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: adaptive immune response;Affect;anti-cancer;Anti-CD47;Antigen Presentation;Area;Attention;Automobile Driving;Binding;Biochemical;Biological;Biological Assay;Biological Products;Biological Response Modifiers;Blocking Antibodies;CD47 gene;CD47-SIRPα;Cell Differentiation process;Cell Lineage;Cell surface;cell type;Cells;cellular targeting;Chemosensitization;ChIP-seq;clinical predictors;clinically relevant;clinically significant;CRISPR/Cas technology;Cytotoxic T-Lymphocytes;Data;design;Detection;Disease;DNA;effector T cell;Frequencies;Goals;Growth;Homeostasis;Human;Immune;Immune Evasion;Immunologic Surveillance;Immunotherapeutic agent;in vivo;Infiltration;innate immune checkpoint;Macrophage Activation;Mediating;melanocyte;Melanoma;Melanoma Cell;Melanoma patient;Melanoma Tumor;Metastatic Melanoma;Modeling;Molecular;Molecular Target;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Neoplasm Metastasis;neoplastic cell;nuclear respiratory factor;Organism;overexpression;Pathogenesis;patient derived xenograft model;Patient Selection;Patients;Phagocytes;Physiological;Predictive Value;Production;programmed cell death protein 1;promoter;Property;PTPNS1 gene;Publications;Reactive Oxygen Species;receptor;Recurrent disease;Regimen;Regulation;research study;Resistance development;response;Role;Signal Transduction;Surface Antigens;T cell response;T-Cell Proliferation;T-Lymphocyte;Therapeutic;therapeutically effective;Time;Tissues;transcription factor;Transgenes;treatment response;tumor;tumor growth;tumor microenvironment;tumor-immune system interactions;Up-Regulation;virtual

PROJECT_TITLE: Therapeutic Mechanism of CD47 Blockade in Suppressing Melanoma Metastasis

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Women's Health Research

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE The devastating effects of the COVID-19 pandemic have reverberated through every aspect of our civilization. While SARS-CoV-2, the viral etiology of COVID-19, seems to spare infants in terms of actual infection, it is currently unknown whether maternal infection during pregnancy will have long-term effects on children born during the pandemic. Detecting COVID-19-related early neurobehavioral effects on mothers and the next generation will provide insights into intervention strategies and contribute significantly to our understanding of children's developmental origins of health and disease and stress science in general.

PI_NAMEs: DUMITRIU, DANI  (contact);MARSH, RACHEL ;MONK, CATHERINE E

PROGRAM_OFFICER_NAME: ZEHR, JULIA L

PROJECT_TERMS: 2019-nCoV;Affect;Behavior;Biological Markers;Brain;brain behavior;caregiving;Caring;Characteristics;Child;Childhood;Civilization;Clinical;cohort;COVID-19;COVID-19 detection;COVID-19 pandemic;COVID-19 pandemic effects;COVID-19 severity;Data;Development;Disadvantaged minority;Disease;Electroencephalography;emotion dysregulation;Emotional;Enrollment;Ethnic Origin;Etiology;Exposure to;Face;Functional disorder;Future;Health;heart rate variability;Home;Hospitals;immune activation;indexing;Infant;Infection;innovation;insight;Intervention;Life;Long-Term Effects;low socioeconomic status;Magnetic Resonance Imaging;maternal stress;Mediation;Medical center;member;Mental Depression;Mental Health;minority communities;Mood Disorders;Mothers;multidisciplinary;multimodality;Neighborhoods;neurobehavioral;neurodevelopment;Newborn Infant;next generation;novel virus;Outcome;pandemic disease;Pathway interactions;pediatrician;Pediatrics;perceived stress;Physiological;Play;Population;Positioning Attribute;Postpartum Period;Pregnancy;pregnant;Pregnant Women;prenatal;prenatal exposure;Provider;Psychologist;Questionnaires;Race;recruit;Risk;routine care;Sampling;SARS-CoV-2 exposure;SARS-CoV-2 positive;Science;Scientist;Serology;Serology test;sex;Smell Perception;Stress;Structure;Testing;Universities;Vertical Transmission;Viral;wearable device;Woman

PROJECT_TITLE: COVID-19 Mother Baby Outcomes (COMBO): brain-behavior functioning

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Food Allergies;Immunization;Immunotherapy;Prevention;Vaccine Related

ORG_CITY: DURHAM

ORG_DEPT: PATHOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative: This proposal will develop mRNA vaccines that encode for the dominant peanut allergen Ara h 2 as a native protein and mutant proteins lacking IgE epitopes and disrupt known IgE epitopes. These vaccines will be evaluated for transfection efficiency, and immunogenicity and safety in mice. The results of this proposal will produce first-generation mRNA peanut allergen vaccines that may be further developed as immunotherapeutics to treat peanut hypersensitivity.

PI_NAMEs: JOHNSON-WEAVER, BRANDI  (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: 2019-nCoV;Address;Adjuvant;Affect;Allergen Immunotherapy;Allergens;Allergic;Allergic Disease;Allergic Reaction;allergic response;Allergy to peanuts;Anaphylaxis;Antibodies;Antigens;CD8-Positive T-Lymphocytes;Cell Degranulation;cell mediated immune response;Clinical;Communicable Diseases;COVID-19 pandemic;COVID-19 vaccine;crosslink;Data;desensitization;Developed Countries;Development;Dose;Epitopes;Event;Exposure to;FDA approved;Food Hypersensitivity;Formulation;Foundations;Future;Generations;Goals;granulocyte;Human;Hypersensitivity;IgE;IgG(T);Immunization;Immunize;immunogenicity;Immunoglobulin A;Immunoglobulin G;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo;Individual;Inflammation Mediators;Length;Life;mast cell;Mediating;Medical;Messenger RNA;Methods;Monitor;Mus;mutant;Mutate;Mutation;natural hypothermia;Nose;Oral;Oral Administration;oral immunotherapy;Package Insert;Persons;Population;Prevalence;prevent;Product Approvals;Production;protein expression;Protein Truncation;Proteins;Research;response;Risk Reduction;RNA;RNA vaccine;Route;Safety;Serum;Severities;Surface;Symptoms;T cell response;T-Lymphocyte;T-Lymphocyte Epitopes;Technology;Testing;Time;Transfection;vaccine platform;Vaccine Production;Vaccines;Western Blotting

PROJECT_TITLE: Developing RNA Vaccines to Treat Peanut Hypersensitivity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-K(57)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Nutrition;Osteoporosis;Patient Safety;Prevention;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Public Health Relevance: Osteoporosis is common and devastating for long‐term care residents, yet few are treated and clinical trials are scarce. This study examines an innovative approach for geriatric osteoporosis: robust bone building followed by maintaining skeletal integrity in this frail cohort.

PI_NAMEs: GREENSPAN, SUSAN L (contact)

PROGRAM_OFFICER_NAME: SAZONOVA, IRINA Y

PROJECT_TERMS: 3-Dimensional;absorption;Address;Adverse event;Age;Anabolic Agents;bone;Bone Density;bone loss;Bone structure;bone turnover;Calcium;cardiovascular risk factor;Cardiovascular system;Characteristics;Clinical Trials;Cognitive;cohort;Communities;comorbidity;Consensus;Consumption;cost;data mining;Death Rate;Dependence;Disease;Double-Blind Method;efficacy evaluation;efficacy testing;Elderly;Electronics;Enrollment;Event;Exclusion;Face;FDA approved;Forteo;Fracture;fracture risk;Frail Elderly;Functional impairment;Funding;Goals;Health;Health care facility;high risk population;Hip Fractures;Hip region structure;Hospitalization;human old age (65+);Hypercalcemia;Image;Immobilization;Impaired cognition;improved;Incidence;inhibitor;innovation;Institutionalization;International;Investigation;Lateral;Location;Long-Term Care;Malnutrition;Measurement;Measures;Mobility decline;Monitor;neglect;Notification;novel;Oral;Osteoporosis;osteoporosis with pathological fracture;Outcome;Patients;Personal Satisfaction;Pharmaceutical Preparations;Placebos;point of care;Population;Postmenopause;prevent;public health relevance;Quality of life;Randomized;Regression Analysis;Resources;responders and non-responders;Risk;Safety;sedentary;Self Administration;Serious Adverse Event;side effect;Site;skeletal;Spinal Fractures;spine bone structure;Structure;subcutaneous;substantia spongiosa;System;Techniques;Testing;Time;Trabecular Bone Score;United States National Institutes of Health;Vertebral column;Vitamin D;Vitamin D Deficiency;Woman;Zoledronic Acid

PROJECT_TITLE: Innovative Approach to Geriatric Osteoporosis

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Mental Health;Mental Illness;Neurosciences

ORG_CITY: MADISON

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE – New treatments for anxiety disorders are critically needed and a more complete understanding of pathological anxiety at the molecular, cellular and circuit level will provide a foundation for new treatment development. Using our non-human primate model of extreme anxiety, the proposed studies will use neuroimaging, molecular sequencing techniques and chemogenetics to understand the extent to which neurons in the basolateral amygdala can serve as treatment targets. Additionally, these studies will serve as a proof-of- concept to understand the feasibility of developing chemogenetic approaches for the future treatment of severe and refractory psychiatric disorders.

PI_NAMEs: KALIN, NED H (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Acute;Affect;Aftercare;Amygdaloid structure;Animals;Anti-Anxiety Agents;Anxiety;anxiety-related behavior;anxious temperament;Behavior;behavior test;Behavioral;behavioral phenotyping;Brain;brain tissue;Cell Nucleus;cell type;Chronic;Collaborations;design;Designer Drugs;Development;emotion regulation;Enhancers;excitatory neuron;Female;Foundations;Functional disorder;Future;Gene Delivery;Gene Expression;Gene Expression Profile;Genetic;genetic approach;Genetic study;Human;improved;Individual;Individual Differences;insight;Interneurons;Laboratories;Macaca mulatta;male;Mediating;Mental disorders;Methods;Modeling;Molecular;Monkeys;neural;neural circuit;neuroimaging;Neurons;nonhuman primate;Output;Pathological anxiety;Phenotype;preadolescence;Primates;Process;Psychopathology;receptor;Recombinant adeno-associated virus (rAAV);Recurrence;Refractory;Regulation;response;Rodent;Role;single nucleus RNA-sequencing;Source;Stress;stress related disorder;Structure;Structure of terminal stria nuclei of preoptic region;Symptoms;Techniques;Technology;Testing;Therapeutic Effect;therapy design;therapy development;Time;Tissues;transcriptome sequencing;transmission process;Treatment Efficacy;treatment of anxiety disorders;treatment strategy;Viral Vector;Withholding Treatment;Work

PROJECT_TITLE: Development and Regulation of Emotion in Primates

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Hematology;Orphan Drug;Patient Safety;Physical Activity;Rare Diseases

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Patients with locally advanced rectal cancer (LARC) commonly have poor tolerability to total neoadjuvant therapy, which reduces cancer control and survival benefit of this treatment. We propose to investigate the dose- response of aerobic training (AT) on total neoadjuvant therapy tolerability in patients with LARC. Results from this investigation will identify the AT dose that maximizes total neoadjuvant therapy tolerability in LARC, and will provide essential evidence supporting integration of AT into clinical cancer care.

PI_NAMEs: CERCEK, ANDREA ;SCOTT, JESSICA  (contact)

PROGRAM_OFFICER_NAME: TESAURO, GINA M

PROJECT_TERMS: Address;Adherence;adjudication;Aerobic Exercise;Age;Anemia;Anti-emetics;Apoptosis;Attenuated;Behavior Therapy;Biological;Biological Assay;Blinded;cancer care;Cancer Control;cancer diagnosis;cancer initiation;Cancer Patient;cancer survival;cancer therapy;cancer type;Case Report Form;Cessation of life;chemoradiation;chemotherapy;Chemotherapy and/or radiation;Clinical;clinical practice;Clinical Research;Common Terminology Criteria for Adverse Events;Complete Blood Count;Correlative Study;Data;design;Diagnosis;digital;Disease-Free Survival;Dose;Electronics;Erythrocytes;Evaluation;Event;evidence base;Exercise;exercise intensity;Exercise Therapy;F2-Isoprostanes;Fatigue;Female;Flow Cytometry;Generations;Guidelines;Hematology;Hematopoietic stem cells;Hemoglobin;Home;Impairment;improved;In complete remission;Incidence;Induction of Apoptosis;Investigation;Knowledge;Local Therapy;male;Malignant Breast Neoplasm;Malignant Neoplasms;Mass Spectrum Analysis;meetings;Modeling;Modification;Neoadjuvant Therapy;Neutropenia;neutrophil;Oncologist;Oncology;Operative Surgical Procedures;Outcome;Pathologic;Patient Education;Patient Outcomes Assessments;patient population;Patient Schedules;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phase;Phase II/III Trial;Physiological;Pilot Projects;point of care;Postoperative Complications;preclinical study;primary endpoint;progression risk;Proliferating;Protocols documentation;psychosocial outcome;Qualifying;Quality of life;Random Allocation;randomized trial;Reactive Oxygen Species;real time monitoring;Recommendation;Recovery;Rectal Cancer;Regimen;Reporting;Research;response;Safety;Sample Size;Schedule;sex;Site;standard of care;Standardization;Structure;Survival Rate;Techniques;Testing;Time;Toxic effect;Translating;treadmill;treatment planning;Treatment-related toxicity;tumor;Walking;Work

PROJECT_TITLE: Dose-response of aerobic training during total neoadjuvant therapy for locally advanced rectal cancer


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative The buildup of misfolded proteins can cause Alzheimer's disease and related dementias (ADRD), which are becoming more prevalent as the population continues to live longer. This project will leverage a new genetic technology to greatly enhance our understanding of the intricate networks of molecular chaperones, which are the cell’s natural defense system against protein misfolding. This new approach will uncover the specific molecular chaperones that can serve as future targets for therapeutics against ADRD.

PI_NAMEs: BARBIERI, EDWARD MATTHEW (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Advisory Committees;age related;Aging;Alzheimer's disease related dementia;Biochemistry;Biological Assay;Brain Diseases;Cell model;Cells;Cellular Assay;Collaborations;combat;combinatorial;Complement;Complex;CRISPR-mediated transcriptional activation;Cytoplasm;Engineering;Enzymes;Eukaryota;experimental study;Flow Cytometry;Frontotemporal Dementia;Funding;Future;Genes;Genetic;genetic approach;Genetic Techniques;genetic technology;genetic variant;Goals;Heat shock proteins;heat-shock proteins 110;Human;In Vitro;in vitro Assay;Individual;insight;Learning Skill;Libraries;Maps;Measures;Mentors;Messenger RNA;misfolded protein;Modeling;Molecular Chaperones;Molecular Genetics;mutant;Mutation;Nerve Degeneration;Neurodegenerative Disorders;neuronal survival;Neurons;novel strategies;Organism;overexpression;Pathologic;Pathology;Pennsylvania;Phase;Phenotype;Population;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;Preparation;Prevention;Process;programs;protein expression;protein misfolding;protein purification;protein TDP-43;Proteins;Proteome;proteostasis;proteostasis loss;reconstruction;Reporter Genes;Research;RNA Splicing;screening;skill acquisition;skills;Specificity;Stress;System;targeted treatment;tau aggregation;tau Proteins;TDP-43 aggregation;Testing;therapeutic target;tool;Toxic effect;Training;Translating;Triplet Multiple Birth;United States National Institutes of Health;Universities;Work;Yeast Model System;Yeasts

PROJECT_TITLE: Synthetic Reconstruction of Human Chaperone Networks in Yeast Models of Neurodegeneration

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Lung;Nanotechnology;Prevention;Social Determinants of Health;Vaccine Related

ORG_CITY: WOBURN

ORG_NAME: APHIOS CORPORATION

PHR: PROJECT NARRATIVE COVID-19 has quickly become the most impactful healthcare, social, and economic crisis of our lifetime. The pandemic has disrupted everyday life abruptly and unpredictably at a global scale, and all predictions indicate that the virus will become endemic and cause regular outbreaks in the form of mutants. The impact of the pandemic is even more pronounced for racial and economic minorities, and for socioeconomically disfavored individuals and groups. To assist in the resolution of these crises, we plan to develop a single-shot, room- temperature stable, double-nanoencapsulated mRNA vaccine for COVID-19. This vaccine, in addition, can be easily modified to cover mutant viruses that constantly emerge, and it will be a significant component of the vaccination armamentarium during the current and future pandemics.

PI_NAMEs: CASTOR, TREVOR P. (contact)

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: 2019-nCoV;Acute;Address;Allergic Reaction;Animal Model;Antigens;biodegradable polymer;Biological Sciences;biological systems;Cessation of life;Clinical Research;Communicable Diseases;Coronavirus;coronavirus disease;coronavirus pandemic;Coronavirus spike protein;Country;COVID-19;COVID-19 mortality;COVID-19 patient;COVID-19 vaccine;Cryopreservation;current pandemic;Development;Disease;Disease Outbreaks;Dose;Drug Kinetics;Economics;Education;Encapsulated;Engineering;Ensure;European Union;face mask;Fatality rate;Freeze Drying;Future;future pandemic;Gene Proteins;Goals;Government;Healthcare;Human;Hypersensitivity;immunogenicity;Immunologist;In Vitro;in vivo;in vivo evaluation;Individual;Industry;Injections;innovation;Life;Life Expectancy;Lipids;Liquid substance;manufacturability;Measures;Mental Health;Messenger RNA;Middle East Respiratory Syndrome;Middle East Respiratory Syndrome Coronavirus;Minority;Modification;Molecular;mRNA Stability;multidisciplinary;mutant;nanoencapsulated;nanoformulation;nanoparticle;nanopolymer;Nanosphere;novel coronavirus;Organ;pandemic disease;pandemic impact;Persons;Phase;Phospholipids;pill;Polyethylene Glycols;Polymers;Poverty;pre-pandemic;Prevention strategy;Process;Race;Reaction;reconstitution;remdesivir;Reporting;Resolution;RNA vaccine;Safety;SARS coronavirus;scale up;Severe Acute Respiratory Syndrome;social;Social Distance;Societies;socioeconomics;Solvents;Specific qualifier value;Technology;Temperature;Therapeutic;Universities;Vaccination;Vaccines;vector-based vaccine;Viral;Viral Vector;Virus

PROJECT_TITLE: Double-Encapsulated mRNA Vaccine for COVID-19

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-U(11)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Biomedical Imaging;Clinical Research;Machine Learning and Artificial Intelligence;Osteoarthritis;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Prevention;Rehabilitation

ORG_DEPT: ORTHOPEDICS

PHR: Project Narrative Meniscus injuries are very common and frequently lead to early onset osteoarthritis, a leading cause of disability. This project will identify biomechanical and biological predictors of cartilage degeneration after meniscus injury and partial meniscectomy. Our findings will be utilized to improve care and outcomes for patients suffering from meniscus injuries.

PI_NAMEs: DEFRATE, LOUIS E.;GOODE, ADAM ;MCNULTY, AMY L (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: articular cartilage;Biochemical;Biological;Biological Factors;Biological Markers;biomechanical test;Biomechanics;Body Weight decreased;Cadaver;Caring;Cartilage;cartilage degradation;Cells;Characteristics;Clinical;clinical phenotype;Cluster Analysis;Computer Models;Data;Degenerative polyarthritis;demographics;Development;Dinoprostone;disability;early onset;Environment;Flow Cytometry;Future;Goals;Health;high risk;Image;imaging biomarker;Immune;improved;improved outcome;in vivo;Individual;Inflammation Mediators;Inflammatory;joint destruction;joint inflammation;joint injury;Joints;Knee;Knee Osteoarthritis;Lateral;Lead;Machine Learning;Macrophage;Magnetic Resonance Imaging;Maps;Matrix Metalloproteinases;Measures;Medial;Medial meniscus structure;meniscus injury;Meniscus structure of joint;Metabolic;Methods;Nonpharmacologic Therapy;Operative Surgical Procedures;Orthopedic Procedures;Participant;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmacologic Substance;Phenotype;Physical Rehabilitation;Physical therapy;Play;predictive modeling;prevent;primary outcome;Procedures;Public Health;radiological imaging;random forest;rehabilitation strategy;response;Risk;Roentgen Rays;Role;Serum;Speed;Subgroup;Synovial Fluid;targeted treatment;Techniques;Thick;three-dimensional modeling;Time;Tissues;treadmill;Validation;Walking

PROJECT_TITLE: Biomechanical and Biological Predictors of Cartilage Health Following Meniscus Injury

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative  Clostridioides difficile is a toxin-producing bacterium that is a frequent cause of hospital-acquired and antibiotic-associated diarrhea. The United States Centers for Disease Control reports that in 2017, there were 223,900 estimated cases of C. difficile infection (CDI) in hospitalized patients with an estimated 12,800 deaths in the United States. This program is designed to provide the discovery and advanced immunological understanding needed to create durable and effective vaccines for the prevention of CDI in humans.

PI_NAMEs: LACY, DANA BORDEN (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Address;Adult;Age;Anaerobic Bacteria;Animal Testing;anti-toxin;antibiotic-associated diarrhea;Antibiotics;Antibodies;Antibody titer measurement;Antigens;B-Lymphocytes;Bacteria;Binding;Biochemical;Blood;Cell Separation;Cells;Centers for Disease Control and Prevention (U.S.);Cessation of life;Chemicals;Clinical;Clinical Trials;Clostridioides difficile vaccine;Clostridium difficile;Colon;Communities;Complement;Data;design;Development;Diarrhea;Disease;efficacy trial;Elderly;Ensure;Epitope Mapping;Epitopes;Evaluation;experience;experimental study;Foundations;gastrointestinal infection;Genetic;Genomics;Goals;Hospitalization;Hospitals;Human;Immune;Immune response;Immunity;Immunization;Immunoglobulin A;Immunoglobulin G;Immunologics;improved;in vivo;Incidence;Individual;Infection;Inflammation;innovation;Intestines;Lead;Libraries;Life;Light;Link;Lymphocyte;Mediating;member;Membrane Proteins;Memory B-Lymphocyte;Methods;mouse model;Mucosal Immune Responses;Mucous Membrane;multidisciplinary;novel;novel vaccines;Pathology;Patients;Persons;pre-clinical;Pre-Clinical Model;Prevalence;prevent;Prevention;Production;programs;Pseudomembranous Colitis;Recurrence;recurrent infection;Reporting;Reproduction spores;Research;Research Personnel;Resources;response;Route;Safety;Sampling;Secretory Immunoglobulin A;Services;Severities;Severity of illness;Structure;Surface;Surface Antigens;Symptoms;Therapeutic;Tissues;tool;Toxin;Toxoids;Transferase;Translating;United States;Vaccination;vaccination strategy;vaccine development;vaccine efficacy;vaccine formulation;vaccine strategy;vaccine trial;Vaccines;Virulence Factors;Work

PROJECT_TITLE: Vanderbilt Antibody and Antigen Discovery for Clostridioides difficile Vaccines


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

PROJECT_TERMS: Academic Medical Centers;Antibodies;Antigens;Clostridioides difficile vaccine;commercialization;Communities;Complex;Data;Ensure;enteric infection;experience;Feedback;Fostering;Goals;Human Resources;improved;Institution;Intellectual Property;Leadership;Link;meetings;member;Monitor;Mucosal Immunity;National Institute of Allergy and Infectious Disease;Notification;Productivity;programs;public database;Reagent;Reporting;Research;Research Personnel;Resources;Science;success;Technology Transfer;Travel;United States National Institutes of Health

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Brain Disorders;Neurosciences

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: The cerebellum is a structure that is critical for control of movements. However, activities of cerebellar neurons are often difficult to interpret in terms of behavior. Here, we propose new algorithms and experimental procedures that will significantly improve the ability to tackle the question of neural population coding in the cerebellum, ultimately producing a better understanding of how the cerebellum learns to precisely control movements.

PI_NAMEs: SHADMEHR, REZA  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TITLE: Control of movements by the cerebellum

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

PI_NAMEs: NICHOLSON, MARIBETH RUTH (contact)

PROJECT_TERMS: Academic Medical Centers;administrative database;Adult;Age;Aliquot;antibiotic-associated diarrhea;Antibodies;Antibody Response;Antigens;Basic Science;biobank;Biological;Biological Specimen Banks;Biological Specimen database;Blood;Child;Clinical;Clinical Data;clinical data repository;clinical database;Clinical Microbiology;clinical outcome measures;Clinical Research;Clostridioides difficile vaccine;Clostridium difficile;cohort;Collaborations;Collection;Consent;Data;data de-identification;Data Element;Databases;demographics;Development;Elements;Enrollment;Ensure;Epidemiology;Evaluation;Feces;Future;Gastroenterology;Gender;Goals;high risk;Immune response;Immunity;Individual;Infection;Infection prevention;Institutional Review Boards;Laboratories;Link;Maintenance;Measures;Medical center;Medical History;member;Metadata;Microbiology;Morbidity - disease rate;mortality;Outcome;Outcome Measure;Participant;participant enrollment;Patient Participation;Patient Recruitments;patient retention;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;primary care clinic;Process;prospective;Protocols documentation;Records;recruit;Recurrent disease;Reproducibility;Research Personnel;Research Training;Residual state;Resources;Role;Saliva;sample collection;Sampling;Secure;Serum;Source;Specimen;Standardization;stool sample;success;System;tertiary care;Testing;Therapeutic;Time;Toxin;Toxoids;Translational Research;United States;Vaccines;web platform;Whole Blood;Work

PROJECT_TITLE: CORE 1: The Clinical Data and Biospecimen Repository Core


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: The results of this translational study will provide the first evidence that a targeted intervention with an anti- inflammatory medication can reverse both the underlying pathology and depressive state in “inflammatory depression” in rodents and humans. As such, our findings will be of direct benefit to MDD patients by providing alternative, targeted treatment options, so as to improve poor remission rates currently associated with use of monoaminergic antidepressants.

PI_NAMEs: DELORENZO, CHRISTINE ;PARSEY, RAMIN V. (contact)

PROGRAM_OFFICER_NAME: LAWHORN, COLLENE

PROJECT_TERMS: Accounting;Affect;Affinity;Aftercare;anti-depressive agents;Anti-Inflammatory Agents;antidepressant effect;Astrocytes;biological heterogeneity;Brain;celecoxib;Chronic;Clinical;Clinical Trials;clinically relevant;cohort;Data;density;Depressed mood;depression model;depressive symptoms;design;Disease;Disease remission;disorder subtype;Enrollment;Evaluation;Exclusion;Exhibits;Functional disorder;Genetic Polymorphism;Genotype;Health;healthy volunteer;Heterogeneity;Human;Image;improved;in vivo;Individual;Inflammatory;inflammatory marker;insight;Intervention;Major Depressive Disorder;Measures;Medicine;Mental Depression;Messenger RNA;Microglia;microPET;Modeling;Molecular;Morphology;mouse model;Mus;Neuroglia;neuroinflammation;novel;optimal treatments;Outcome;Outer Mitochondrial Membrane;Participant;Pathology;Patient Recruitments;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Pilot Projects;Population;Positron-Emission Tomography;Prefrontal Cortex;prevent;protein expression;Proteins;Proxy;Psychiatry;Reporting;response;Rodent;Selective Serotonin Reuptake Inhibitor;Severities;Signal Transduction;single episode major depressive disorder;social defeat;Stress;Subgroup;targeted treatment;Testing;Text;translational study;Treatment outcome;treatment strategy;volunteer;Wild Type Mouse

PROJECT_TITLE: A translational study of neuroinflammatory depression: Understanding mechanism and evaluation of a novel pharmacologic intervention


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE The NHGRI Genome Technology (GT) Program supports innovation, development, and early dissemination of genomic technologies. The goal of the Genome Technology Coordinating Center (GTCC) is to accelerate technology development and progress in the field of genomics through its support of GT grantees. To achieve this, the GTCC will pursue three over-arching objectives: 1) coordinating interactions among NHGRI Genome Technology grantees to enhance communication and encourage setting and meeting of performance objectives, 2) managing an Opportunity Funds program to promote early-stage development of innovative technologies, and 3) facilitating outreach by grantees to share results of their efforts with the scientific community.

PI_NAMEs: ADAMS, MARK D (contact)

PROGRAM_OFFICER_NAME: MORRIS, STEPHANIE A

PROJECT_TERMS: Acceleration;Access to Information;Adoption;Area;Award;Awareness;Benchmarking;Biological;Biology;centralized portal;Collaborations;Communication;Communities;Community Outreach;comparative;Complex;Data;Development;Disease;Education;Education and Outreach;education resources;Educational Materials;Evaluation;experience;Experimental Models;Exposure to;Foundations;Funding;Funding Opportunities;Genetic Research;Genome;genome analysis;genome-wide;Genomic medicine;Genomics;Goals;Grant;Human Genetics;Human Genome;human model;improved;Informatics;Information Resources;innovation;innovative technologies;insight;Institution;instrumentation;Intellectual Property;interest;Laboratories;Malignant Neoplasms;Mammalian Genetics;Medicine;meetings;mouse genome;National Human Genome Research Institute;new technology;novel strategies;Nucleic acid sequencing;Nucleic Acids;Office of Administrative Management;Outcome;outreach;Peer Review;Performance;Persons;Phenotype;Pilot Projects;Process;programs;Qualifying;Recording of previous events;Research;Research Personnel;Resources;Role;Science;Scientist;Standardization;Structure;success;symposium;Technology;technology development;Technology Transfer;The Jackson Laboratory;trait;Underrepresented Populations;Underserved Population;virtual;web site;working group

PROJECT_TITLE: Genome Technologies Coordinating Center


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Nutrition

ORG_DEPT: VETERINARY SCIENCES

PHR: Our proposed studies will determine a functional link between aging-related processes and etiology of AD using animal models.

PI_NAMEs: HORVATH, TAMAS L (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Aging;aging process;aging related;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;Animal Experiments;Animal Model;Animals;anti aging;Behavioral;Biochemical;Biochemistry;Biological Markers;Brain;Brain Pathology;Caloric Restriction;Calories;Cell Physiology;Clinical;Clinical Trials;Control Animal;Dementia;Development;Disease;effective therapy;Electrophysiology (science);Etiology;Evaluation;FGF21 gene;fibroblast growth factor 21;Genes;Geroscience;Histologic;Human;Human Amyloid Precursor Protein;Hunger;Hypothalamic structure;Impaired cognition;Impairment;in vivo;Intervention;intervention effect;Life Expectancy;Link;Mediating;Metabolism;Methods;Modeling;mouse model;mutant;Neuronal Dysfunction;Neurons;novel strategies;novel therapeutics;Nutrient;Outcome Study;Pathologic;Pathology;Peptides;pharmacologic;pre-clinical;presenilin-1;Prevalence;Primates;Process;Publishing;Rat Transgene;Rattus;Symptoms;Testing;Tg2576;Therapeutic Intervention;Transgenic Mice

PROJECT_TITLE: Hypothalamus-driven anti-aging processes impact murine models of Alzheimer's Disease


PI_NAMEs: SPILLER, BENJAMIN W (contact)

PROJECT_TERMS: Antibodies;Antibody Response;antigen binding;Antigens;Bacillus megaterium;Cells;Clostridioides difficile vaccine;Clostridium difficile;Codon Nucleotides;Core Protein;Cryoelectron Microscopy;Electron Microscopy;Epitopes;Escherichia coli;Evaluation;Excision;experience;experimental study;Fab Immunoglobulins;Frequencies;Futility;Goals;holotoxins;Human;IgG1;Immune response;Immunoglobulin A;Immunoglobulin G;improved;Length;member;Methods;Molecular;neutralizing antibody;novel;novel vaccines;Patients;primary endpoint;protein expression;protein purification;Proteins;Reagent;Sampling;Sorting;Specificity;structural biology;Structure;Subunit Vaccines;Toxin;Vaccination;vaccine candidate;vaccine development;vaccine trial;Vaccines;Validation;X-Ray Crystallography

PROJECT_TITLE: CORE 2: Protein Expression and Purification Core


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: STANFORD

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Heart failure is a syndrome of major public heath significance. It is estimated that >6.2 million US citizens suffer from heart failure, with about one million new cases diagnosed annually. A better understanding of the cellular mechanisms that control cardiac remodeling, including pathological myocyte hypertrophy, should yield better therapeutic regimens with decreased mortality.

PI_NAMEs: KAPILOFF, MICHAEL SETH (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: Adrenergic Agents;Adult;Agonist;Allosteric Site;Angiotensin II;Attenuated;beta-adrenergic receptor;Binding;Ca(2+)-Transporting ATPase;Calcineurin;calcineurin phosphatase;Calmodulin;Cardiac;Cardiac Myocytes;cdc42 GTP-Binding Protein;Cell membrane;Cell Physiology;Cells;Clinical;Co-Immunoprecipitations;Complex;Contracts;Coronary artery;Coupling;Data;Dependovirus;Development;Diagnosis;Diglycerides;Distal;Elements;Enzymes;Exhibits;experimental study;Family;Fluorescence Resonance Energy Transfer;functional independence;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Gene Targeting;Genetic;Guanosine Triphosphate Phosphohydrolases;Heart;Heart failure;heart function;Heart Hypertrophy;Hypertrophy;Image;Immunosuppressive Agents;improved;In Vitro;inhibitor;insight;Ion Channel;Ischemia;Knockout Mice;Left;Ligation;Mediating;member;Membrane;Membrane Proteins;Modeling;Monomeric GTP-Binding Proteins;mortality;Mus;Muscle Cells;mutant;Myocardial Infarction;myocardial injury;Myocardial Ischemia;N-terminal;new therapeutic target;NFAT Pathway;novel;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Pathologic;Phosphoric Monoester Hydrolases;Phosphoserine;polyproline;pressure;Prevention;Protein Isoforms;Proteins;Public Health;Pump;Rattus;receptor;recruit;Regimen;Regulation;Reperfusion Injury;Reperfusion Therapy;Reporter;response;rho;RHO Effector Domain;RNA Interference;Role;Sarcomeres;Scaffolding Protein;Second Messenger Systems;sensor;Signal Pathway;Signal Transduction;Source;Specific qualifier value;Specificity;Stains;Stress;Structure;Syndrome;Testing;theories;Therapeutic;therapeutic target;Threonine;TRIP10 gene;Ventricular;Vesicle;VIVIT peptide

PROJECT_TITLE: Calcineurin compartmentation and regulation of pathological cardiac remodeling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MIM-R(01)]


ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: Project narrative We discovered that the host has evolved physiological defenses that promote the asymptomatic carriage of pathogens through a phenomenon we call “metabolic bribery”. This involves physiological responses in the host that operate to provide metabolic substrates to the pathogen, taming their virulence and preventing their ability to cause disease. We plan to decipher the host metabolic adaptations that occur in asymptomatic carriers that facilitate metabolic bribery, the interplay between the adaptive immune system and the cooperative defenses to promote cooperation between the host and a pathogen, and develop a mechanistic understanding for how cooperative defenses promote the evolution of attenuation of a pathogen and commensalism.

PI_NAMEs: AYRES, JANELLE S (contact)

PROJECT_TERMS: Acute;adaptive immune response;Adaptive Immune System;Address;Affect;Antibody Response;Attenuated;attenuation;Behavior;carbohydrate metabolism;Carbohydrates;Chronic;Citrobacter;Citrobacter rodentium;Colitis;Data;Defense Mechanisms;dietary;Disease;Enteral;enteric pathogen;Evolution;fitness;gastrointestinal;Glucose;glucose metabolism;Goals;gut microbiota;Health;Host Defense;host microbiota;Immune response;Immunocompromised Host;Immunology;in vivo;Individual;Infection;Infectious colitis;Inflammation;Intestines;Investigation;Iron;Lead;lipid metabolism;Lipids;Macronutrients Nutrition;Mediating;member;Metabolic;Metabolic Control;Metabolism;Microbe;microbial;microbial community;microbiota;Micronutrients;Modeling;mouse model;Mucous Membrane;Mus;novel;Outcome;pathogen;pathogenic bacteria;pathogenic microbe;Pathogenicity;Pathology;Pathway interactions;Phenotype;Physiological;Physiology;prevent;Process;programs;Regulation;Research;response;Role;Starvation;Symbiosis;synergism;System;tool;transmission process;Virulence;Virulent;Work

PROJECT_TITLE: Tolerance defenses in host-microbiota interactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-P(02)]


PI_NAMEs: GEORGIEV, IVELIN  (contact)

PROJECT_TERMS: Antibodies;Antibody Repertoire;Antibody Response;Antigen Targeting;Antigens;B-Cell Antigen Receptor;B-Lymphocytes;Back;Bacteria;Cell Separation;Cells;Clinical;clinically significant;Clostridioides difficile vaccine;Clostridium difficile;Core Protein;Coronavirus;Data;Data Analyses;Epitopes;experimental study;Goals;Hepatitis C;HIV-1;Human;Immunology;Individual;Infection;Influenza;innovation;Libraries;Light;Link;Microfluidics;next generation sequencing;pathogen;Peripheral Blood Mononuclear Cell;Production;Proteins;Sampling;Science;screening;single cell technology;Sorting;Specificity;Techniques;Technology;Therapeutic antibodies;therapeutic candidate;Work

PROJECT_TITLE: Core 3: Single-Cell Core


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Organ Transplantation;Transplantation

ORG_CITY: Nashville

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

PHR: PROJECT NARRATIVE Computer-assisted interpretation of renal histopathology using whole slide imaging (WSI) has dramatically advanced both the research and practice for the diagnosis and scoring of specific causes of chronic kidney disease (CKD). However, current phenotyping approaches are restricted to investigating two dimensional (2D) sections, which are error-prone due to the heterogeneity of kidney tissue (e.g., glomeruli) across three dimensional (3D) serial sectioning. We seek to enable AI-empowered 3D interpretation of routine digital renal histopathology, so as to (1) allow renal pathologists to perform a reproducible 3D phenotyping on serial 2D whole slide images (WSI), (2) advance the characterization of kidney-allograft rejection phenotypes on kidney transplant patients with cutting-edge 3D computer vision, and (3) equip clinical scientists with an advanced 3D spatial transcriptomics analytics tool to investigate the anatomical-molecular associated causes of chronic kidney disease (CKD).

PI_NAMEs: HUO, YUANKAI  (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: 3-Dimensional;Adult;Algorithms;allograft rejection;Allografting;analytical tool;Anatomy;Appearance;Biological Markers;Biopsy;Caring;Cell Communication;cell type;Characteristics;Chronic Kidney Failure;Classification;Clinical;clinical phenotype;Computer Assisted;Computer software;Computer Vision Systems;cost;Decision Making;deep learning;design;Diagnosis;digital;digital imaging;digital pathology;Elements;empowerment;Focal and Segmental Glomerulosclerosis;Future;Gene Expression Profile;glomerulosclerosis;Goals;Grain;Healthcare;Heterogeneity;Histopathology;Human BioMolecular Atlas Program;Image;imaging biomarker;imaging modality;Individual;International;Kidney;kidney allograft;Kidney Diseases;Kidney Transplantation;Label;Lesion;Methods;Modeling;Molecular;molecular marker;Morphologic artifacts;Morphology;Needle biopsy procedure;Nephrotic Syndrome;novel;Pathogenesis;Pathologist;Pathology;Patient Care;Patients;personalized diagnostics;Phenotype;Prognosis;Renal Tissue;Reproducibility;Research;routine practice;Scientist;self supervised learning;Stains;Standardization;Structure;success;Techniques;Technology;Three-Dimensional Imaging;three-dimensional visualization;Tissues;tool;transcriptomics;Transplant Recipients;two-dimensional;United States National Institutes of Health;Visualization;whole slide imaging

PROJECT_TITLE: AI-empowered 3D Computer Vision and Image-Omics Integration for Digital Kidney Histopathology

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: Project Narrative Depression and anxiety disorders are major public health problems but our understanding of and treatment for these prevalent disorders remain lacking. To address these unmet needs, we propose an integrated research program through a unified Conte Center that will investigate the role of cortico-striatal-midbrain and nociceptin circuitry in approach-avoidance behaviors and in the pathophysiology of depression and anxiety disorders, towards the goals of identifying (1) novel treatment targets and (2) markers that map disease course. This will be achieved by bringing together a highly interdisciplinary team with complementary expertise and an established track record of successful collaborations, and who will be tackle these scientific challenges through experiments across species (mice, non-human primates, and humans) and units of analyses (genes, molecule, cells, circuits, physiology, behavior, and self-report).

PI_NAMEs: PIZZAGALLI, DIEGO A (contact)

PROGRAM_OFFICER_NAME: ZALCMAN, STEVEN J

PROJECT_TERMS: Address;Adult;Affect;Animal Model;Animals;antagonist;Anxiety;Anxiety Disorders;approach/avoidance behavior;Behavior;Behavioral;Behavioral Model;Behavioral Paradigm;bench-to-bedside translation;Cells;Clinical;Collaborations;Computer Models;Corpus striatum structure;CRISPR/Cas technology;Custom;Data;Decision Making;Deep Brain Stimulation;depressive symptoms;Disease;Dopamine;Eating Disorders;effective therapy;efficacious treatment;Experimental Designs;experimental study;Functional disorder;General Hospitals;Genes;Genetic;Genetic Techniques;Goals;Hospitals;Human;human model;Image;improved;innovation;Investigation;knock-down;Knowledge;Lead;Link;Major Depressive Disorder;Maps;Massachusetts;Measures;Mediating;Mental Depression;Mental disorders;Midbrain structure;Modeling;Molecular Target;Mood Disorders;Mus;National Institute of Mental Health;neural;neural circuit;neurobiological mechanism;neuroimaging;Neuromodulator;Neurons;Neurotransmitters;nociceptin;nonhuman primate;novel;optogenetics;ORL1 receptor;Patient Self-Report;pharmacologic;Phenotype;Physiology;Population;Process;programs;Public Health;Punishment;Research;Rewards;Rodent;Role;Stress;Substance Use Disorder;suicidal risk;Support System;System;technological innovation;Testing;therapy development;translational impact;Translations;treatment response;Universities;Up-Regulation;Washington;Work

PROJECT_TITLE: Novel Treatment Targets For Affective Disorders Through Cross-Species Investigation of Approach/Avoidance Decision Making


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Mental Illness;Neurosciences

PROJECT_TERMS: Adherence;advocacy organizations;Affect;Affective;Anxiety Disorders;approach/avoidance behavior;Award;Behavior;biomarker identification;Budgets;career development;Cells;Clinical;cohesion;Collaborations;Communities;community engagement;Community Health;Community Outreach;Computer Models;Corpus striatum structure;Data;data platform;data sharing;Decision Making;Development;Diffusion;Disease;Education and Outreach;Educational Activities;effective therapy;Ensure;Evaluation;Faculty;Fellowship;Fostering;Functional disorder;General Hospitals;General Population;Genes;Goals;graduate student;Grant;Hand;Hospitals;Human;improved;Institution;interest;Investigation;Knowledge;Maps;Massachusetts;medical schools;meetings;Mental Depression;Mental disorders;Mental Health;Mentorship;Midbrain structure;minority scientist;Mission;Modeling;Molecular Target;Monitor;Mood Disorders;Mus;National Institute of Mental Health;neuropsychiatric disorder;nociceptin;nonhuman primate;novel;operation;Output;outreach;outreach program;Parameter Estimation;Patient advocacy;Patient Self-Report;Physiology;Play;Population;Postdoctoral Fellow;Program Development;programs;Progress Reports;recruit;Research;Research Domain Criteria;Research Personnel;Resource Sharing;Resources;Role;Schools;Scientist;Series;Site;Students;symposium;synergism;Technology;timeline;Training;Training and Education;translational neuroscience;undergraduate student;Universities;Washington;web site;Woman

PROJECT_TITLE: Administrative Core_Pizzagalli


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Alcohol consumption during pregnancy causes Fetal Alcohol Spectrum Disorders (FASD). Disruption of endoplasmic reticulum (ER) homeostasis may contribute to alcohol-induced damage to the developing brain. The study will explore the underlying mechanisms and develop a new therapeutic approach.

PI_NAMEs: LUO, JIA  (contact)

PROGRAM_OFFICER_NAME: AKBAR, MOHAMMED

PROJECT_TERMS: Adolescence;Adult;Adverse effects;Alcohol consumption;alcohol consumption during pregnancy;alcohol exposure;alcohol sensitivity;Alcohol-Induced Disorders;Alcohols;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Apoptosis;Apoptotic;Attention;Brain;Calcium;Cell Death;Cell Survival;Cells;Central Nervous System;Central Nervous System Diseases;Chemicals;Child;coping;deprivation;Development;Diagnosis;Drug Targeting;Endoplasmic Reticulum;endoplasmic reticulum stress;FDA approved;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Genes;genetic manipulation;Glucose;Homeostasis;Huntington Disease;Hyperactivity;improved;improved outcome;In Vitro;in vivo;Individual;Induced Neurons;Intervention;Mediating;Mental disability;misfolded protein;Molecular;mRNA Differential Displays;Nerve Degeneration;Nervous System Trauma;neurobehavioral;Neurodegenerative Disorders;neuroinflammation;Neurons;neurotoxicity;Neurotransmitters;neurotrophic factor;novel;novel therapeutic intervention;Organelles;Outcome;Oxidation-Reduction;Oxidative Stress;Parkinson Disease;Pathologic;Pathway interactions;Pharmaceutical Preparations;Play;Predisposition;Pregnant Women;prenatal experience;prenatal therapy;Prion Diseases;Property;protein folding;protein misfolding;Proteins;proteostasis;Quality Control;Regulation;Reporting;Resistance;response;Role;Signal Transduction;skills;societal costs;Structure;System;Testing;Toxicant exposure;transcriptomics

PROJECT_TITLE: Endoplasmic Reticulum Stress and Alcohol Neurotoxicity

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: PROJECT NARRATIVE Genetically-engineered mice are instrumental to better understand human development and disease and to develop and improve drugs and therapeutics. The Mutant Mouse Resource and Research Center at the University of Missouri provides a unique repository for importing, storing and distributing a vast number of genetically-engineered mice, germplasm, embryonic stem cells and related reagents. The center also performs critical broad-based research and services to ensure quality, reproducibility and translatability of mouse models with an emphasis on the role of complex gut microbiota in model phenotypes.

PI_NAMEs: AMOS-LANDGRAF, JAMES  (contact);FRANKLIN, CRAIG L

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Acceleration;Agreement;Archives;Biocompatible Materials;Biomedical Research;California;Caring;Cell Separation;Cloning;Collaborations;Communities;Complement;Complex;Cryopreservation;Data;Deposition;Derivation procedure;Development;disease model;Embryo;embryo cryopreservation;embryonic stem cell;Ensure;Equity;Fees;Funding;Gene Targeting;Genetic;Genetic Engineering;Genetically Engineered Mouse;Genotype;Germ;Germ Cells;Goals;gut microbiome;gut microbiota;high risk;Human Development;human disease;improved;Informatics;Knock-in;Knock-out;meetings;member;Methods;Missouri;Modeling;Mouse Embryonic Stem Cells;mouse genetics;mouse model;Mus;Mutagenesis;Mutant Strains Mice;Names;National Center for Research Resources;new technology;NIH Mouse;North Carolina;pathogen;Pharmaceutical Preparations;Phenotype;Policies;preservation;Procedures;Protocols documentation;Qualifying;Quality Control;Reagent;repository;Reproducibility;Research;Research Personnel;Resources;Role;Scientist;Services;sperm cell;sperm cryopreservation;System;Technology;Testing;The Jackson Laboratory;Therapeutic;Transgenic Organisms;United States;United States National Institutes of Health;Universities;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-C(50)]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

PROJECT_TERMS: Acute;Anatomy;Anhedonia;antagonist;Anterior;Anxiety;Anxiety Disorders;approach behavior;approach/avoidance behavior;Automobile Driving;Autopsy;Behavior;Behavioral;Behavioral Model;Biological Assay;Biological Markers;Cell Nucleus;Chronic stress;cingulate cortex;Clinical;Corpus striatum structure;Data;Decision Making;design;Diagnostic;diagnostic strategy;Disease;Disease remission;Dopamine;dopamine transporter;dopaminergic neuron;Dose;Double-Blind Method;Ecological momentary assessment;Exposure to;follow-up;Functional Magnetic Resonance Imaging;genetic approach;Goals;Grant;Hospitals;Human;human study;Individual;Investigation;Life;Link;Major Depressive Disorder;Mental Depression;Midbrain structure;Mood Disorders;Mus;neural;neural correlate;Neurobiology;neuroimaging;Neurons;nociceptin;nonhuman primate;novel;Nucleus Accumbens;ORL1 receptor;Pathway interactions;Patients;Peptide Receptor;Peptides;pharmacologic;Phenotype;Placebo Control;Placebos;Plasma;Play;Prefrontal Cortex;Process;prospective;Psychiatry;Psychosocial Stress;psychosocial stressors;Rattus;receptor expression;Relapse;Rodent;Sampling;Signal Pathway;Stress;stressor;striosome;suicidal;suicide rate;System;Testing;therapy development;treatment response;Tyrosine 3-Monooxygenase;Ventral Striatum

PROJECT_TITLE: Project 1_Pizzagalli : Pharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies


PI_NAMEs: SKAAR, ERIC P (contact)

PROJECT_TERMS: Animal Experimentation;Animal Model;Animal Welfare;Animals;Antibodies;Antigens;Area;Autopsy;Biological Products;Board Certification;Clinical;clinical practice;clinically relevant;Clostridioides difficile vaccine;Clostridium difficile;Development;digital pathology;Disease;efficacy evaluation;efficacy testing;Ensure;Equipment;experience;Foundations;Goals;human disease;human model;IACUC;in vivo;in vivo evaluation;in vivo Model;Infection;Laboratories;Lead;Maintenance;Modeling;molecular pathology;mouse model;Mus;novel;novel vaccines;Organism;Pathogenicity;Pathologic;Pathologist;Pathology;prevent;prevention practice;Program Development;programs;Proteins;Protocols documentation;Regulation;Resource Sharing;Sampling;screening;small molecule;System;Technical Expertise;Testing;therapeutic evaluation;Tissues;Training;Treatment Efficacy;vaccination strategy;vaccine candidate;vaccine development;Veterinary Anatomy;Work

PROJECT_TITLE: CORE 4- Small Animal Core


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Clinical Research;Genetic Testing;Genetics;Human Genome;Precision Medicine;Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative While prostate cancer screening reduces death from prostate cancer, it does so at the cost of unnecessary treatment of men with nonaggressive disease. To address this, we propose to identify inherited genetic changes that influence survival time after a diagnosis of prostate cancer and incorporating such genetic information into prostate cancer screening tools. If successful, this will enable more precise prostate cancer screening, reducing both death from prostate cancer and unnecessary treatment.

PI_NAMEs: KLEIN, ROBERT J. (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Address;Adverse event;Biochemical;Biological Markers;Biology;biomarker panel;Biopsy;cancer diagnosis;Cancer Etiology;Cancer Patient;cancer survival;Cells;Cessation of life;Clinic;Clinical;clinical risk;clinical translation;clinically significant;Code;cohort;cost;Data;Diagnosis;Disease;Disease Progression;Distant Metastasis;Early Diagnosis;exome sequencing;follow-up;Genes;Genetic;Genetic Determinism;genetic information;genetic predictors;genetic risk factor;Genetic study;genetic testing;genetic variant;genome wide association study;Genomic approach;Genomics;Germ Lines;Hematopoietic Neoplasms;Heritability;high risk;high risk men;Hospitals;Image;Impairment;improved;Indolent;Inherited;insight;kallikrein 4;Kininogenase;Knowledge;Length;Malignant - descriptor;Malignant neoplasm of prostate;Malignant Neoplasms;men;middle age;model design;Modeling;Mutation;novel;Pathway interactions;peripheral blood;PF4 Gene;Play;population based;predictive marker;Price;Prognostic Factor;Prostate;prostate cancer progression;Prostate Cancer therapy;PSA screening;Quality of life;rare variant;Recurrence;Reflex action;Risk;risk stratification;Role;screening;Screening for Prostate Cancer;Screening procedure;Signal Transduction;Single Nucleotide Polymorphism;Testing;Time;trait;Transcription Alteration;transcriptome;Translating;Twin Studies;United States;unnecessary treatment;Variant;Work

PROJECT_TITLE: Genetic Predictors of Prostate Cancer Survival

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Epilepsy;Major Depressive Disorder;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Rehabilitation;Serious Mental Illness

PI_NAMEs: DOUGHERTY, DARIN D (contact)

PROJECT_TERMS: Acute;Affect;Animals;Anterior;Anxiety Disorders;approach behavior;approach/avoidance behavior;Area;avoidance behavior;awake;Behavior;Behavior assessment;Behavioral;Brain;Brain region;capsule;Cell Nucleus;Chronic;cingulate cortex;Code;Conflict (Psychology);Corpus striatum structure;Data;Decision Making;Deep Brain Stimulation;depressed patient;Desire for food;Dorsal;Electrodes;Electroencephalography;Epilepsy;experience;Frequencies;Functional Imaging;Functional Magnetic Resonance Imaging;General Hospitals;Goals;Grant;Human;human model;imaging study;Implant;implantation;Individual;insight;Investigation;Lateral;Link;Major Depressive Disorder;Mammals;Massachusetts;Measurement;Medial;Mediating;Mental Depression;Mental disorders;Midbrain structure;millisecond;Monitor;Mood Disorders;Nature;neural;neural network;neurobiological mechanism;neuroimaging;Neurons;neuropsychiatric disorder;neuropsychiatry;nociceptin;nonhuman primate;novel;Nucleus Accumbens;Operative Surgical Procedures;Pathway interactions;Patient Admission;Patients;Performance;Prefrontal Cortex;Punishment;Reaction Time;recruit;Resolution;Rewards;Risk;Rodent;Role;Seizures;Signal Transduction;Site;Stimulus;striosome;Structure;synergism;Task Performances;temporal measurement;Testing;Ventral Striatum;Ventral Tegmental Area

PROJECT_TITLE: Project 2_Dougherty: Invasive Recording and Neurostimulation Studies of Approach/Avoidance Behaviors in Humans


PI_NAMEs: LACY, DANA BORDEN (contact)

PROJECT_TERMS: Anaerobic Bacteria;anti-toxin;Antibiotics;Antibodies;Antibody Response;Antigens;B-Cell Antigen Receptor;Binding;C-terminal;Cessation of life;Clinical;Clinical Trials;Clostridioides difficile vaccine;Clostridium;Clostridium difficile;Colonoscopy;Community-Acquired Infections;Correlation Studies;Crosslinker;Cryoelectron Microscopy;Data;Diarrhea;Elderly;Epitopes;expectation;Formalin;gastrointestinal infection;Generations;Goals;health care settings;Hospitalization;Hospitals;Human;human disease;Immune response;Immune system;Immunity;Immunization;immunogenic;Immunoglobulin A;Immunoglobulin G;Immunologic Memory;improved;Infection;infection risk;intraperitoneal;Lead;Left;Life;Link;Methods;Monoclonal Antibodies;Morbidity - disease rate;Mucosal Immune Responses;Mucosal Immunity;Mucous Membrane;Mus;Nosocomial Infections;novel;Organism;Outcome;Patients;Persons;Point Mutation;Population;Pre-Clinical Model;prevent;Prevention;primary endpoint;Production;Productivity;programs;Property;Proteins;Pseudomembranous Colitis;Rectum;Recurrence;Regimen;Reporting;Reproduction spores;Research;response;Risk Reduction;saliva sample;salivary assay;sample fixation;Sampling;screening;Sepsis;Sequence Analysis;Serum;Services;Severities;Specificity;Structure;Symptoms;T-Lymphocyte;Technology;Toxic effect;Toxic Megacolon;Toxin;Toxoids;Transferase;United States;Vaccination;vaccination strategy;Vaccine Clinical Trial;vaccine development;vaccine strategy;Variant;Virulence Factors;young adult

PROJECT_TITLE: Project 1: Mucosal toxin subunit immunization as a strategy for C. difficile vaccine development


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences

PI_NAMEs: GRAYBIEL, ANN M (contact)

PROJECT_TERMS: Affect;affective disturbance;Agonist;Anhedonia;antagonist;Anterior;Anti-Anxiety Agents;Anxiety;Anxiety Disorders;approach/avoidance behavior;Area;avoidance behavior;Behavior;Behavioral;Behavioral Assay;behavioral study;Chronic stress;cingulate cortex;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Corpus striatum structure;Costs and Benefits;Decision Making;design;Dissection;Dopamine;dopamine system;dopaminergic neuron;Dorsal;Dose;Electric Stimulation;experimental study;Exposure to;Face;Fiber;forging;Functional disorder;Genes;genetic manipulation;Goals;Head;Human;human subject;imaging approach;improved;Individual;Infrastructure;Interruption;Investigation;Label;Link;Macaca;Major Depressive Disorder;Massachusetts;Measures;Mental Depression;Mental disorders;microstimulation;Mission;Modeling;Molecular;Molecular Genetics;Monkeys;Mood Disorders;Moods;Motivation;Mus;National Institute of Mental Health;neural;neural circuit;neurochemistry;neuronal circuitry;Neurons;neurophysiology;neuropsychiatric disorder;neuropsychiatry;neuroregulation;nociceptin;nonhuman primate;novel;ORL1 receptor;Outcome;Patients;Pattern;Peptide Receptor;Peptides;pharmacologic;Phenotype;Photometry;Physiology;prepronociceptin;prevent;receptor expression;Research;Research Personnel;Resources;Rodent;Rodent Model;Role;Running;selective expression;Services;Signal Induction;Signal Transduction;Site;Stress;striosome;Structure;Technology;Testing;Therapeutic;Validation;Work

PROJECT_TITLE: Project 3_Graybiel : Circuit-Specific Disruption, Pharmacological, and Neurophysiological Studies of Approach/Avoidance Behaviors in Mice and Non-Human Primates


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Malaria;Pediatric;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: BAMAKO

ORG_COUNTRY: MALI

ORG_FIPS: ML

ORG_NAME: UNIV OF SCIENCES, TECH & TECH OF BAMAKO

PHR: PROJECT NARRATIVE Seasonal malaria chemoprevention (SMC) provides regular administration of antimalarial medication to children during the malaria transmission season to protect them from malaria episodes. One concern is that SMC impairs the acquisition of protective immune responses, thereby increasing the risk of disease in later years. With a multi-season cohort study of malaria incidence among Malian children receiving SMC, we will determine how SMC affects malaria vulnerability across pediatric populations and the location of parasite reservoirs in the community, which are both crucial to guiding control interventions and eventually eliminating malaria in regions such as Mali.

PI_NAMEs: COULIBALY, DRISSA  (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Affect;Africa South of the Sahara;African;Age;age group;Age Months;age related;aged;Alleles;Amodiaquine;Anti-malarials;Antibody Response;Antigens;Area;Artemisinins;Beds;Biological Assay;Blood;Cause of Death;Cessation of life;Chemoprevention;Child;Childhood;Cohort Studies;Combined Modality Therapy;Communities;Culicidae;Custom;detection assay;Disease;disorder risk;Dryness;Epidemiology;Future;Geographic Information Systems;Goals;Home;Human;human old age (65+);Immune response;Impairment;Incidence;infancy;Insecticides;interest;Intervention;Knowledge;Location;Malaria;malaria infection;malaria transmission;Mali;Maps;Measures;Medicine;Molecular;novel strategies;Parasitemia;Parasites;Pharmaceutical Preparations;Plasmodium;Plasmodium falciparum;Population;Predisposition;Pregnancy;Pregnant Women;prevent;Preventive treatment;Prospective, cohort study;Protein Array;Protein Microchips;Pyrimethamine;Recommendation;Recording of previous events;Research;Risk;Rural;Seasons;Shapes;Site;Spatial Distribution;Sulfadoxine;Testing;Therapeutic;Time;transmission process;vaccine evaluation;Variant;Vulnerable Populations;World Health Organization

PROJECT_TITLE: The age-specific impact of seasonal malaria chemoprevention on malaria incidence, antibody responses, and parasite reservoirs in Malian children

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: Project Narrative Primary care settings lack interventions to address the childhood obesity epidemic that are feasible and sustainable without requiring significant resources. We propose to modify and test an intervention shown to lower children’s BMI so that it is feasible, sustainable, and easily disseminated in a real-world clinical setting. If successful, we will be able to provide recommendations to providers and health care systems that help prioritize future intervention strategies and research investments to reduce obesity in children that can be quickly translated into other settings and widely adopted after the study period, with the goal of halting and reversing the childhood obesity epidemic.

PI_NAMEs: KOEBNICK, CORINNA  (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: 11 year old;Address;Adopted;Adoption;Age;aged;Appointment;attentional control;Behavior;behavior change;Behavior Therapy;Black race;Body mass index;Body Weight;California;Caring;Cellular Phone;Characteristics;Child;Child health care;Childhood;Clinic;Clinical;clinical care;Communication;Computerized Medical Record;Counseling;dosage;Dose;Education;effective intervention;Effectiveness;effectiveness evaluation;effectiveness testing;efficacy study;electronic medical record system;Enrollment;ethnic minority;Ethnic Origin;evidence base;experience;Family;follow-up;Friends;Future;Goals;health care settings;Healthcare Systems;Heterogeneity;Hispanic;Individual;Infrastructure;Insurance;Intervention;Intervention Studies;Investments;Life Style;Low income;Low Income Population;Maintenance;Methods;Minority;Motivation;motivational enhancement therapy;nutrition;Obesity;Obesity Epidemic;obesity in children;obesity treatment;Overweight;Parents;Patients;Persons;Population;Positioning Attribute;pragmatic randomized trial;pragmatic trial;prevent;Primary Care;primary care practice;primary care provider;primary care setting;Provider;Race;racial minority;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;Resources;response;screening;sex;socioeconomic diversity;System;Techniques;Telephone;telephone coaching;Testing;Text;Time;tool;Training;Translating;treatment as usual;virtual;Weight maintenance regimen

PROJECT_TITLE: Reducing Childhood Obesity through EHR-supported Motivational Interviewing

STUDY_SECTION: PRDP

STUDY_SECTION_NAME: Psychosocial Risk and Disease Prevention Study Section[PRDP]