NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Lung;Lung Cancer;Pediatric;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

ORG_STATE: CA

PHR: Tobacco product packaging is a particularly important form of advertising and marketing. There is a need for research that examines whether introducing standardized tobacco packages (that is, replacing colorful, logo- heavy packages with drably colored packages that include little, if any, color or product branding) diminishes risk of tobacco use. The research proposed in this application will conduct an experiment with young adults to fill this gap, and to inform policy decisions relating to tobacco package design.

PI_NAMEs: SHADEL, WILLIAM G (contact)

PROGRAM_OFFICER_NAME: RODITIS, MARIA LEIA

PROJECT_TERMS: Adolescent;Advertising;Age;Amendment;Area;Attention;Australia;Behavior;Characteristics;Child;Cigar;Cigarette;cigarillos;Cognition;Color;Communication;design;Electronic Nicotine Delivery Systems;Elements;Environment;experience;experimental study;Exposure to;Goals;Government;health warning;Industry;Intellectual Property;Legal;Life;Location;Marketing;Mediating;Mediator;Modeling;Names;older adult;Outcome;Perception;Policies;Population;Product Packaging;Public Health;Randomized;reduce tobacco use;Regulation;Research;Rights;Risk;Safety;Sales;Smokeless Tobacco;Speech;Standardization;Surface;Testing;Text;Tobacco;tobacco exposure;tobacco flavor;Tobacco Industry;tobacco products;tobacco regulation;Tobacco use;Trademark;United States;Variant;Vulnerable Populations;World Health Organization;young adult

PROJECT_TITLE: The Impact of Standardized Tobacco Product Packaging on Young Adults in the Retail Environment

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BROAD INSTITUTE, INC.

ORG_STATE: MA

PHR: PROJECT NARRATIVE  The thalamic reticular nucleus (TRN), the major source of thalamic inhibition, plays critical roles in regulating information passing between thalamus and neocortex. TRN dysfunction may underlie sensory abnormality, attention deficit and sleep disruption across multiple neurodevelopmental disorders. Despite its central importance, current understanding about how TRN neurons regulate such diverse functions is still limited. The current proposed work aims to investigate structure-function relationships in distinct TRN networks regulate behavioral processes in health and disease.

PI_NAMEs: FU, ZHANYAN  (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Acute;Address;anatomical tracing;Anatomy;Animals;Arousal;Attention;Attention deficit hyperactivity disorder;Attentional deficit;autism spectrum disorder;awake;Behavior;Behavioral;Brain;Cell Nucleus;cell type;Cells;Characteristics;Cognition;CRISPR/Cas technology;Diagnostic;Disease;Dissociation;Dorsal;Electrodes;Electrophysiology (science);Enterobacteria phage P1 Cre recombinase;Functional disorder;Genes;Genetic;Glutamates;Health;in vivo;Individual;information processing;Injections;Knock-out;Knowledge;Label;Link;Maps;Mediating;Molecular;mouse model;mutant mouse model;Mutant Strains Mice;Neocortex;Neurodevelopmental Disorder;Neurons;Noise;novel;optogenetics;Output;patch clamp;Pathway interactions;Pattern;Physiological;Play;Population;Positioning Attribute;Process;Property;rabies viral tracing;Role;Schizophrenia;Sensory;Sleep disturbances;Slice;Source;Structure-Activity Relationship;Structure/Function Nuclei;Synapses;System;Testing;Thalamic Nuclei;Thalamic structure;Therapeutic;Thinness;Time;tool;Tracer;transcriptome sequencing;transcriptomics;Transgenic Mice;transmission process;Work

PROJECT_TITLE: Characterization of structure-function relationships in distinct thalamic reticular nucleus networks


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: PHILADELPHIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Interventional Oncology is emerging as the fourth pillar of cancer care alongside medical, radiation, and surgical oncology. Interventional oncologists provide minimally invasive image- guided therapies to treat cancers without the toxicities and disfigurement of chemotherapy, radiation or surgery. The role of a senior IO Clinical Research Specialist is to foster new clinical trial designs and collaborations which are essential to determine how and when interventional oncologic therapies should be integrated into multidisciplinary care plans to achieve optimal outcomes for cancer patients.

PI_NAMEs: SOULEN, MICHAEL C (contact)

PROGRAM_OFFICER_NAME: MAHER, MOLLY ELIZABETH

PROJECT_TERMS: Ablation;Address;Area;Autophagocytosis;cancer care;Cancer Center;Cancer Patient;Caring;checkpoint inhibition;Chemosensitization;chemotherapy;chimeric antigen receptor T cells;Clinical Investigator;Clinical Oncology;Clinical Research;clinical trial protocol;Clinical Trials;Clinical Trials Design;Collaborations;Discipline;Educational process of instructing;Event;Failure;Fostering;Free Radicals;Generations;image guided;image guided therapy;Immunologic Adjuvants;improved;Injections;Institution;interdisciplinary collaboration;internal radiation;Intervention;Investigation;Ischemia;Malignant Neoplasms;Medical Oncology;medical specialties;minimally invasive;multidisciplinary;nano;novel;novel therapeutics;Oncologist;Oncology;Operative Surgical Procedures;Outcome;Physicians;Process;Radiation;Radiation Oncology;Radiation-Sensitizing Agents;recruit;Research Personnel;Role;Solid Neoplasm;Specialist;Surgical Oncology;synergism;Therapeutic Agents;Therapeutic Embolization;Time;Toxic effect;trial design;Vaccines

PROJECT_TITLE: Interventional oncology clinical research specialist


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: Columbus

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: For healthy metabolism, it is imperative that adequate amounts of sulfur are supplied and that toxic sulfur- containing metabolites are consumed (salvaged) or otherwise removed. When this ability is compromised a number of different scenarios arise that lead to different pathologies in humans and lower organisms. This study considers how sulfur and carbon salvage mechanisms influence metabolism of pathogenic bacteria that cause serious infections in millions of people, with the idea that this work could lead to a specific therapeutic strategy.

PI_NAMEs: NORTH, JUSTIN ANDREW (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: 5'-deoxyadenosine;Address;Aerobic;Amino Acids;analog;Bacteria;Biological Availability;Cancer Cell Growth;Carbon;Cells;Consumption;cost;design;DNA Methylation;Environment;Enzymes;Ethylenes;experimental study;Exposure to;feeding;fitness;Gene Expression;Genes;genetic regulatory protein;Goals;Growth;Health;homoserine lactone;Human;In Vitro;in vivo;Infection;inhibitor;interest;Intestines;Island;Laboratories;Liver Cirrhosis;Lower Organism;Metabolic;Metabolic Pathway;Metabolism;Methionine;Methods;Mutagenesis;mutant;novel;Organism;pathogen;Pathogenesis;pathogenic bacteria;pathogenic Escherichia coli;Pathogenicity;Pathology;Pathway interactions;Persons;Physiological;Polyamines;Prevalence;Process;Protein Methylation;Proteomics;Quantitative Reverse Transcriptase PCR;quorum sensing;Radiolabeled;Reaction;Recycling;Regulatory Element;Resolution;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;Shunt Device;shunt pathway;Siderophores;Site;Structural Genes;Sulfate;Sulfur;Testing;Therapeutic;Therapeutic Agents;transcriptomics;Translating;Work

PROJECT_TITLE: Salvage of the sulfur and carbon byproducts of S-adenosylmethionine metabolism in pathogenic bacteria

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Schizophrenia;Serious Mental Illness

ORG_CITY: DALLAS

ORG_DEPT: PSYCHIATRY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE  Schizophrenia is a severe and debilitating brain disorder with obscure neurobiological mechanisms and limited treatment options. The proposed study will investigate unique aspects of schizophrenia neurobiology— disease course and aging—along the adult lifespan. This research will contribute to fundamental knowledge about brain systems critical for schizophrenia neurobiology, and motivate future studies on the development of precision treatments tailored towards schizophrenia trajectory.

PI_NAMEs: IVLEVA, ELENA IVANOVNA (contact)

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: Acceleration;Adult;Age;age acceleration;age effect;aged;Aging;aging brain;Anterior;Bilateral;Biological;Biological Assay;Biological Markers;biomarker panel;Blood Vessels;Brain;Brain Diseases;Brain imaging;Chronology;Clinical;Cognition;Cognitive;comparison control;Complex;Data;Development;Dimensions;Disease;early psychosis;Episodic memory;episodic memory impairment;Fingerprint;follow-up;Functional Magnetic Resonance Imaging;Future;gamma-Aminobutyric Acid;General Population;Glutamates;Hippocampus;Hyperactivity;Impaired cognition;in vivo;individualized medicine;innovation;Intervention;Investigation;Knowledge;life span;Limbic System;Longevity;loss of function;Magnetic Resonance Imaging;Measures;Medial;Mental disorders;middle age;Modeling;Molecular;molecular marker;Morbidity - disease rate;mortality;multimodality;National Institute of Mental Health;neural;neurobiological mechanism;Neurobiology;normal aging;novel;novel marker;Outcome;Pathology;Pattern;Perfusion;Play;Precision therapeutics;Prefrontal Cortex;Research;Research Design;Resolution;Sampling;Schizophrenia;specific biomarkers;Strategic Planning;Structure;Subgroup;System;targeted biomarker;targeted treatment;therapy development;Thick

PROJECT_TITLE: Aging and Disease Course: Contributions to Lifespan Neurobiology of Schizophrenia


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Social Determinants of Health

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE This is relevant to public health because sustained HIV viral suppression is a key health outcome, benefiting the individual’s health (reduced morbidity, comorbidities, and mortality) and the community because sustained HIV viral suppression is associated with preventing HIV transmission. As the United States makes advancements in HIV care and treatment and gets closer to ending the HIV epidemic, we need to ensure that no one is left behind. People with HIV with low incomes who rely on state AIDS Drug Assistance Programs (ADAPs) experience geographic disparities in viral suppression, and for this population, we will identify the specific policies and healthcare delivery programs that increase sustained viral suppression rates and reduce sustained viral suppression disparities related to race/ethnicity.

PI_NAMEs: MCMANUS, KATHLEEN ANN (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adopted;Advocate;Age;antiretroviral therapy;Arizona;Binding;Black AIDS;Black race;Budgets;Caring;Client;cohort;Communities;comorbidity;Data;Decision Making;Development;Disparity;disparity reduction;District of Columbia;Eligibility Determination;Epidemic;Epidemiologic Methods;Epidemiology;Ethnic Origin;experience;federal poverty level;flexibility;Florida;Funding;geographic disparity;Geography;Goals;Hawaii;Health;Health Care Costs;health care delivery;health equity;Health Services Accessibility;Healthcare;HIV;HIV Infections;improved;Incidence;Income;Individual;insurance plan;Interruption;Intervention;Interview;Laws;Leadership;Left;Low income;Mediating;Morbidity - disease rate;mortality;North Carolina;novel;Outcome;Persons;Pharmaceutical Preparations;Policies;Policy Maker;Population;prevent;Principal Investigator;programs;Public Health;Qualifying;Qualitative Methods;Race;Regulation;Research;Research Personnel;Resource Allocation;Resources;safety net;simulation;South Carolina;Structure;Subgroup;Surveys;Tennessee;Territoriality;Translating;Translations;transmission process;Underinsured;Uninsured;United States;Variant;Viral;Viral Load result;Virginia;Work

PROJECT_TITLE: Viral Suppression for People with HIV with Low Incomes: Study of Disparities, Health Equity, and Best Practices

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: BIRMINGHAM

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative As the HIV epidemic has matured, disproportionate high numbers of new infections are continuing to occur in the Southeastern US. UAB and UMMC have a rich history of HIV/AIDS research and patient care and are uniquely positioned to study the most contemporary scientific questions emerging over the next decade. As such, the UAB/UMMC site will significantly contribute to the knowledge and scientific evidence base aiming to understand the impact of HIV on men and women living with HIV.

PI_NAMEs: BROCK, JAMES BENJAMIN;KEMPF, MIRJAM-COLETTE  (contact);KONKLE-PARKER, DEBORAH J;LEVITAN, EMILY B

PROGRAM_OFFICER_NAME: PATHAK, ELIZABETH BARNETT

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Advisory Committees;Age;Aging;AIDS prevention;Alabama;antiretroviral therapy;Area;Award;Back;Behavioral;black men who have sex with men;black women;cancer care;Cardiovascular Diseases;Cardiovascular system;Caring;Chronic;Chronic Disease;clinical care;clinical practice;Clinical Research;cohort;Cohort Studies;Collaborations;Communication;Communities;Community Outreach;comorbidity;cost effectiveness;Country;Data;Data Analyses;data centers;data quality;data sharing;Deep South;Development;Disease;Education;Enrollment;Ensure;Epidemic;Epidemiology;evidence base;experience;Genetic;Genetic Determinism;Health;health care disparity;Health Disparities Research;health disparity;Health Services Accessibility;Heart;HIV;HIV Infections;HIV Seronegativity;HIV Seropositivity;HIV vaccine;HIV/AIDS;HIV/STD;Human immunodeficiency virus test;Immune;immune activation;Immunogenetics;Income;Infection;Inflammation;innovation;Institution;Jackson Heart Study;Knowledge;Leadership;Link;Malignant Neoplasms;Medical center;men;Mental Health;Mentors;Minority;minority investigator;Mississippi;Modernization;mortality;Neurocognition;Newly Diagnosed;Obesity;Outcome;outreach;Pathogenesis;Patient Care;Patients;Persons;Phenotype;Population;Positioning Attribute;Poverty Areas;Prevalence;Prevention Research;Productivity;protocol development;Protocols documentation;psychosocial;Race;Recording of previous events;Records;recruit;Research;Research Personnel;Resources;response;Rural;Rural Population;sample collection;Scientist;Services;Site;social stigma;Socioeconomic Status;Specimen;STI prevention;stomach cardia;structural determinants;Study Subject;System;T-Lymphocyte;translational scientist;treatment research;United States;United States National Institutes of Health;Universities;vaccine development;Viral;Viral Load result;Visit;Woman;working group;Zoonoses

PROJECT_TITLE: UAB-MISS MACS/WIHS Combined Cohort Study


ADMINISTERING_IC: DK

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Nutrition;Physical Activity;Prevention

ORG_CITY: KNOXVILLE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TENNESSEE KNOXVILLE

ORG_STATE: TN

PHR: Project Narrative This project will develop and validate machine learning algorithms using raw accelerometer and gyroscope sensor data collected at the hip and wrist for use in free-living adults. These algorithms will be able to estimate energy expenditure and classify the type of activity being performed, significantly improving upon current methods that typically only use accelerometer data. These algorithms will have direct benefit to those examining dose response relationships between sedentary behaviors, physical activity and health outcomes in adults, in the physical activity and public health fields.

PI_NAMEs: CROUTER, SCOTT E (contact);DING, WEI

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: Acceleration;Accelerometer;actigraphy;Adult;Algorithms;Ankle;Behavioral trial;Calorimetry;Classification;Clinical Trials;Collection;Complement;Data;data repository;Data Set;Development;Devices;Dose;doubly-labeled water;Energy Metabolism;Expenditure;Future;Health;health record;Hip region structure;Human;improved;Indirect Calorimetry;Individual;Light;Linear Regressions;Location;machine learning algorithm;machine learning model;Measures;Methods;model building;model development;Modeling;Moderate Activity;Moderate Exercise;Monitor;Motion;Movement;Outcome;outcome prediction;Participant;Pattern;Performance;Physical activity;Physical assessment;physical conditioning;portability;Public Health;Research;response;Sampling;sedentary;sedentary activity;sedentary lifestyle;sensor;software repository;Source Code;standard measure;Structure;Techniques;Technology;Testing;Time;Training;wearable device;wearable sensor technology;Work;Wrist

PROJECT_TITLE: Use of accelerometer and gyroscope data to improve precision of estimates of physical activity type and energy expenditure in free-living adults

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Diabetes;Infectious Diseases;Nutrition;Pediatric;Prevention

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: DAISY Project Narrative: March 2020 The Diabetes Autoimmunity in the Young Study (DAISY) will evaluate environmental risk factors for development of islet autoimmunity (IA), in particular those responsible for the increase in T1D incidence in children born between 1993 and 2010. DAISY will investigate the role of enteroviral infections in the etiology of T1D using samples collected from birth and novel technologies. Finally, we will assess progression to T1D among youth with IA older than 15 y.

PI_NAMEs: REWERS, MARIAN J (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Adolescent;Affinity;Age;antibody detection;Antibody Repertoire;Antibody Response;Autoantibodies;Autoimmunity;Biological Assay;Birth;Child;Childhood;Clinical;clinical predictors;cohort;Cohort Studies;Collaborations;college;Colorado;Continuous Glucose Monitor;Date of birth;Diabetes Mellitus;diabetes risk;Diet;Dose;early childhood;endocrine pancreas development;Enrollment;Enterovirus;Enterovirus Infections;Environmental Exposure;Environmental Risk Factor;environmental tobacco smoke exposure;Epitopes;Etiology;Evolution;follow-up;Frequencies;Future;Genotype;Gluten;Goals;HLA-DR Antigens;Human;Incidence;Infant;Infection;Insulin-Dependent Diabetes Mellitus;islet autoimmunity;islet cell antibody;Laboratories;Leukocytes;Life;Medicine;Monitor;Natural History;Nested Case-Control Study;new technology;non-diabetic;overweight child;Peripheral;Poliovirus Vaccines;Population;Prediabetes syndrome;Prevention trial;prospective;protective factors;Risk;Role;Sampling;screening;seroconversion;Serum;Smoking;Testing;Time;Universities;Viral Antibodies;virology;Virus;young adult;Youth

PROJECT_TITLE: Natural History of Pre-Diabetic Autoimmunity (DAISY)

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Type 1 diabetes develops as a result of a complex dialogue that is established between immune cells that infiltrate the pancreatic islet and injured and dying β cells. miRNAs are small noncoding RNAs that modulate expression of genes, and accumulating data suggest that β cell miRNA expression patterns are dynamically modulated during the evolution of type 1 diabetes. This proposal seeks to define the role of inflammatory-induced miRNAs in β cell death and diabetes pathophysiology and will test the idea that detection of β cell-derived miRNAs can serve as biomarkers of type 1 diabetes risk.

PI_NAMEs: EVANS-MOLINA, CARMELLA  (contact)

PROJECT_TERMS: 3' Untranslated Regions;Address;Autoantibodies;Autoimmunity;Beta Cell;Binding;Biological Markers;Cell Death;Cell Physiology;Cell Survival;Cells;Cellular Stress;chemokine;Childhood;Chronic;Clinical;clinical biomarkers;Complex;Cues;cytokine;Data;Data Set;Detection;Development;Diabetes Mellitus;diabetes pathogenesis;diabetes risk;Disease;Evolution;Exhibits;experimental study;Exposure to;extracellular vesicles;Female;Fluorescent in Situ Hybridization;Functional disorder;Gene Expression;Genetic Transcription;Goals;High Fat Diet;Homicide;Human;imaging approach;Immune;immune cell infiltrate;Immune system;Inflammatory;injured;Insulin;insulin dependent diabetes mellitus onset;insulin secretion;Insulin-Dependent Diabetes Mellitus;intercellular communication;Interferon Type II;Interleukin-1 beta;Invaded;islet;Islets of Langerhans;Knowledge;male;Measures;Mediating;Mediator;Messenger RNA;Metabolic Diseases;MicroRNAs;Modeling;Molecular;mouse model;mRNA Transcript Degradation;mRNA Translation;Mus;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;Organ Donor;overexpression;Pancreas;Pancreatic Injury;Pathogenesis;Pathway interactions;Pattern;Phenotype;Plasma;Play;Porifera;posttranscriptional;Process;programs;Quantitative Reverse Transcriptase PCR;Research;response;Role;sexual dimorphism;Signal Pathway;single molecule;Small RNA;Streptozocin;Stress;Testing;Therapeutic Intervention;Tissues;transcriptome sequencing;Untranslated RNA;Up-Regulation;Validation;Work

PROJECT_TITLE: β cell miRNAs Function as Molecular Hubs of Type 1 Diabetes Pathogenesis

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Dementia;Neurodegenerative;Neurosciences;Pain Research;Palliative Care

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative More evidence is needed to improve the quality of life of persons living with advanced dementia and their caregivers. This training program will increase the evidence base for dementia palliative care by identifying and training diverse investigators in the design, funding, conduct, monitoring/oversight, ethical performance, and reporting of dementia palliative care clinical trials.

PI_NAMEs: KUTNER, JEAN S;POLLAK, KATHRYN I;RITCHIE, CHRISTINE S (contact);VRANCEANU, ANA-MARIA

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Address;advanced dementia;Aggressive behavior;Alzheimer's Disease;Alzheimer's disease related dementia;Anthropology;Applications Grants;care fragmentation;care seeking;career development;Caregiver Burden;caregiver strain;Caregivers;Caring;Cause of Death;Clinical;Clinical Trials;Clinical Trials Design;cohort;Collaborations;collaboratory;community engaged research;Conduct Clinical Trials;Confusion;Cost Savings;Dementia;dementia care;design;Discipline;Discipline of Nursing;Disease;Distress;education resources;Emotional;Employment;Engineering;Ethics;ethnic diversity;evidence base;experience;Faculty;Family;Family Caregiver;feeding;Foundations;Functional disorder;Funding;Geography;Geriatrics;Goals;human old age (65+);implementation science;improved;Individual;International;Intervention;investigator training;Literature;Malignant Neoplasms;Medical;Medicine;Mental Depression;Mentors;Modeling;Monitor;neuropsychiatric symptom;Neurosciences;next generation;Nonpharmacologic Therapy;older adult;Organ;Outcome;Pain;palliative;Palliative Care;Paranoia;Participant;patient engagement;patient oriented;Patients;Performance;Persons;preference;programs;Psychology;Quality of life;racial diversity;reduce symptoms;Reporting;Research;Research Personnel;satisfaction;Shortness of Breath;skills;Social Work;Societies;Sociology;sound;symptom management;Symptoms;Syndrome;Terminal Disease;Testing;therapy development;Training;Training Programs;United States;United States Agency for Healthcare Research and Quality;United States National Academy of Sciences;United States National Institutes of Health

PROJECT_TITLE: Diversifying and Strengthening Dementia Palliative Care Clinical Trials


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alcoholism, Alcohol Use and Health;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Nutrition;Prevention;Substance Misuse

ORG_CITY: MENLO PARK

ORG_NAME: SRI INTERNATIONAL

PHR: PROJECT NARRATIVE Among the aging population it remains unknown whether Alcohol Use Disorder (AUD) and its alcohol-related cognitive and brain decline increases risk for diagnostic mild cognitive impairment (MCI) or even can result in a classic irreversible dementia. Characterization of brain pathology and its relation to cognitive deficits in AUD compared with MCI and identification of modifiable risk factors may provide biological markers and enhance mechanistic understanding of these disorders. Development of a translational animal model of AUD brain pathology will permit discovery of biological factors in addition to alcohol itself that contribute to brain damage and inform intervention and treatment efforts for reversing pathology and impairment.

PI_NAMEs: PFEFFERBAUM, ADOLF  (contact);ZAHR, NATALIE M

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Affect;Age;age acceleration;age related;Aging;aging population;Alcohol abuse;Alcohol consumption;alcohol exposure;alcohol use disorder;Alcoholism;Alcohols;Animal Model;Animals;Anterior;Behavioral;Biological Factors;Biological Markers;Blood alcohol level measurement;Blood Pressure;Body mass index;Brain;brain circuitry;Brain Injuries;Brain Pathology;causal model;Cell Nucleus;Chronic;Cognitive;Cognitive deficits;Controlled Study;Cross-Sectional Studies;cytokine;Data;deep learning;Dementia;Development;Diagnosis;Diagnostic;Diet;Diffusion Magnetic Resonance Imaging;Disease;drinking;Edema;entorhinal cortex;Episodic memory;Ethanol;Executive Dysfunction;Female;Fiber;Funding;Hippocampus;Human;Illicit Drugs;Impaired cognition;Impairment;Individual;Inferior;Inferior Colliculus;Inflammation;Inflammatory;inflammatory marker;Intervention;Longitudinal Studies;machine learning method;Magnetic Resonance Imaging;male;Malnutrition;Measures;Mediating;meetings;Memory;Memory impairment;Memory Loss;men;mild cognitive impairment;Modeling;modifiable risk;neural circuit;non-alcoholic;nutrition;Nutritional;Obesity;Participant;Pathology;Pathway interactions;Pattern;Phenotype;Physical activity;Population;Prefrontal Cortex;Rattus;Recovery;recruit;Resolution;response;Risk;Risk Factors;Sensory;sex;sex risk;skills;Smoking;Structure;Tectum Mesencephali;Testing;Thalamic structure;Thiamine;Thiamine Deficiency;Visuospatial;white matter;Wistar Rats;Woman

PROJECT_TITLE: CNS Deficits:  Interaction of Age and Alcoholism


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Genetics;Heart Disease;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: This project aims to develop highly mature bioengineered human heart tissues based on the fact that mature adult cardiomyocytes contain more than one copy of DNA (i.e. they are polyploid). We will construct engineered human heart tissues made of polyploid cardiomyocytes and study their structure, function, genetic and metabolic properties, and response to stress. The outcomes of these studies will enable generation of improved organ-on- chip systems for drug development, studies of human heart disease, and regenerative medicine applications.

PI_NAMEs: BURSAC, NENAD  (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: 3-Dimensional;Acceleration;Adult;Affect;ATAC-seq;aurora B kinase;Biological Assay;Biomechanics;Biomedical Engineering;Bioreactors;candidate identification;Cardiac;Cardiac Myocytes;cardiac tissue engineering;cardiogenesis;catalyst;Cell Cycle;Cell Line;Cell Size;Cell Therapy;Characteristics;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;comparison control;complex IV;CRISPR interference;CRISPR screen;CRISPR-mediated transcriptional activation;Cytokinesis;density;Development;Diploidy;disease model;DNA;Dominant-Negative Mutation;Dorsal;drug development;drug testing;Electrophysiology (science);Endowment;Engineering;Environment;EP300 gene;Epigenetic Process;Exhibits;experience;Failure;Fatty Acids;Foundations;Future;Gene Expression;Generations;Genes;Genetic;genetic inducer;genome editing;genome-wide;Genotype;Goals;Heart;Heart Diseases;Hormonal;Human;human disease;Human Engineering;human induced pluripotent stem cells;improved;In Vitro;in vivo;indexing;Insulin-Like Growth Factor I;Ischemia;Lentivirus;Libraries;mechanical load;Mechanics;Metabolic;Metabolism;Methodology;Microtubules;mimetics;Mitochondria;Mitogens;Mitosis;Molecular;Mononuclear;Mus;Myocardium;Names;novel;organ on a chip;Outcome Study;Output;overexpression;Oxidative Stress;pharmacologic;Pharmacologic Substance;Phenotype;Physiological;Ploidies;Polyploidy;postnatal;postnatal development;Proliferating;Property;Proteins;Regenerative Medicine;regenerative therapy;Reperfusion Injury;Reporting;Repression;Research;response;Rodent;Role;segregation;Signal Transduction;Source;stable cell line;Stimulus;Stress;Structure;System;Testing;three dimensional cell culture;Thyroid Hormones;tissue culture;Tissue Engineering;Tissues;trait;transcriptome sequencing;transcriptomics;Workload

PROJECT_TITLE: Engineering Human Heart Tissues with Polyploid Cardiomyocytes

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Breast Cancer;Cancer;Pediatric;Substance Misuse;Underage Drinking;Women's Health Research

ORG_CITY: IOWA CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Alcohol consumption is associated with increased risk and aggressiveness of breast cancer, suggesting that alcohol may enhance tumorigenesis and progression of breast cancer. We hypothesize that alcohol-induced tumorigenesis and aggressiveness are mediated by different mechanisms. This proposal will elucidate the mechanisms of alcohol-induced tumor promotion.

PI_NAMEs: LUO, JIA  (contact)

PROGRAM_OFFICER_NAME: MURRAY, GARY

PROJECT_TERMS: Accidents;addiction;Adolescence;Adolescent;adolescent alcohol effect;adolescent alcohol exposure;Adolescent and Young Adult;Adult;Adult women;Affect;Age;aged;Aggressive behavior;aggressive breast cancer;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol exposure;alcohol risk;Alcoholism;Alcohols;Animal Model;Appearance;Behavior;Behavior Disorders;binge drinking;Brain;Breast Cancer cell line;Breast Cancer Model;breast cancer progression;Breast Cancer Risk Factor;Breast Epithelial Cells;cancer risk;cell transformation;Chronic;Chronic Disease;Clinical Research;Cognitive deficits;critical period;Development;Diagnosis;Disease;drinking;Drug resistance;epidemiology study;Estrogens;Family;Funding;In Vitro;in vitro Model;in vivo;Individual;Injury;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary gland;mammary gland development;Mammary Neoplasms;Mammary Tumorigenesis;Mediating;member;Mental disorders;Mitogen-Activated Protein Kinases;Modeling;Molecular;Mouse Mammary Tumor Virus;Mus;Neoplasm Metastasis;neoplastic cell;novel;p21 activated kinase;p38 Mitogen Activated Protein Kinase;Pathology;Pathway interactions;Phase;Physiological;Predisposition;Prevalence;Process;Progesterone;Protein-Serine-Threonine Kinases;Recurrence;Risk;Risk Factors;Role;Signal Pathway;Structure;Testing;Therapeutic;Time;Transgenic Mice;Treatment outcome;tumor;tumor growth;tumor progression;Tumor Promotion;tumorigenesis;underage drinking;United States;uptake;Vulnerable Populations;young adult

PROJECT_TITLE: ALCOHOL AND BREAST CANCER

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Dopamine neurons projecting to different regions in the striatum exhibit distinct properties and serve distinct functions. The goal of this proposal is to identify the molecular mechanisms by which such functionally segregated dopamine circuits are established in the mammalian brain. Since defects in dopamine signaling underlie many neuropsychiatric disorders, our work may also suggest novel strategies to treat such disorders.

PI_NAMEs: UMEMORI, HISASHI  (contact);WATABE-UCHIDA, MITSUKO

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Address;Adult;Anatomy;Anterior;Area;Attention deficit hyperactivity disorder;autism spectrum disorder;Axon;Behavior;Behavioral;Biological;Brain;Cell Adhesion Molecules;Cells;Code;conditional knockout;Corpus striatum structure;critical period;Data;Defect;Development;differential expression;Disease;Dopamine;dopaminergic neuron;Drug Addiction;Electrons;Electrophysiology (science);Emotional disorder;Environment;Epilepsy;Event;Exhibits;experience;flexibility;Goals;Histologic;Image;in vivo;interdisciplinary approach;Knockout Mice;Learning;Link;Maintenance;Mediating;Microscopic;Midbrain structure;Molecular;Mood Disorders;motivated behavior;Motivation;motor symptom;mouse genetics;Movement;Mus;neural;Neurons;neuropsychiatric disorder;novel;novel strategies;Parkinson Disease;Pattern;Personality Disorders;Pharmaceutical Preparations;Physiological;Physiology;Play;promoter;Property;Proteins;protocadherin 10;protocadherin 19;psychiatric symptom;Regulation;response;Rewards;Role;Schizophrenia;segregation;selective expression;Signal Transduction;skills;Stimulus;Synapses;synaptogenesis;Tail;Techniques;Testing;Time;Work

PROJECT_TITLE: Molecular Codes for the Establishment of Functionally Segregated Dopaminergic Circuits

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: NARRATIVE More potent and sustained androgen receptor targeting has driven an increased incidence of neuroendocrine prostate cancer (NEPC), a lethal form of prostate cancer, that involves a lineage plasticity program. Our preliminary data demonstrate that the loss of protein kinase C (PKC)l/i promotes a metabolic reprogramming that supports cell proliferation and epigenetic changes favoring lineage plasticity during NEPC. The scope of this study is to investigate the role and mechanism of action of PKCl/i to orchestrate serine metabolism and epigenetic regulation in NEPC, and to identify novel vulnerabilities that can be exploited therapeutically for its treatment.

PI_NAMEs: DIAZ MECO CONDE, MARIA TERESA (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Address;Adenocarcinoma;Adenosine;Adopted;aggressive therapy;Anabolism;androgen independent prostate cancer;Androgen Receptor;cancer cell;cancer genome;Cancer Patient;Carbon;Cell Proliferation;Cells;Chromatin Remodeling Factor;Clinical;Complex;Data;design;DNA Methylation;drug resistance development;Enzymes;Epigenetic Process;epigenetic regulation;EZH2 gene;Generations;Histologic;histone methylation;Human;In Vitro;in vivo;Incidence;inhibitor;Laboratories;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Metabolic;Metabolism;Metastatic Prostate Cancer;Methionine;Methyltransferase;Molecular;neoplastic cell;neuroendocrine differentiation;neuroendocrine phenotype;Neuroendocrine Prostate Cancer;next generation;novel;novel therapeutics;Pathway interactions;Phenotype;Phosphorylation;Phosphotransferases;preclinical efficacy;Production;programs;Proliferating;prostate cancer cell;Protein Kinase C;Publishing;Receptor Signaling;refractory cancer;Regulation;Resistance;resistance mechanism;Role;Scheme;Serine;Small Cell Carcinoma;success;Supporting Cell;targeted treatment;Therapeutic;therapeutically effective;trait;tumor;Tumor Suppressor Proteins;Up-Regulation;Variant

PROJECT_TITLE: Novel Pathways in the Control of Lineage Plasticity in Neuroendocrine Prostate Cancer

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: NARRATIVE Despite a significant burden of disease, few research training programs focus on the urgent health priorities critical to women worldwide. The UNC Global Women’s Health Fellowship addresses this gap through a comprehensive two-year program that provides didactic training, overseas field experience, and intensive academic mentorship. Trainees gain the necessary skills and expertise to become independent investigators and leaders in the field of global women’s health.

PI_NAMEs: CHI, BENJAMIN H. (contact)

PROGRAM_OFFICER_NAME: DEYAMPERT, TARA LYNN

PROJECT_TERMS: Fellowship;Women's Health

PROJECT_TITLE: UNC Global Women’s Health Fellowship


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Dementia;Mental Health;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative: Early life stress/adversity (ELS/ELA) is a risk factor for age-related disorders, including psychiatric, neurological and cognitive disorders. Yet, prospective, longitudinal, studies across the life span are critical to identify biomarkers of ELA risk embedded earlier in life, to develop early intervention strategies. The goal of this proposal is to use a prospective, longitudinal design in nonhuman primates and innovative statistical methods to identify early biomarkers/pathways and underlying mechanisms of ELA-related accelerated neural aging trajectories and cognitive decline from young adulthood to middle age. We will leverage a unique population of adult female macaques with ELA (social subordination stress) currently living in social groups and longitudinally characterized from birth through puberty.

PI_NAMEs: ALVARADO, MARIA C;RAPER, JESSICA ;SANCHEZ, MAR M (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: 11 year old;Acceleration;Acids;acute stress;Adult;Adult women;Affect;Age;age acceleration;age related;age related cognitive disorder;Age Years;age-related disease;Aging;aging related;Amygdaloid structure;Amyloid;Amyloid beta-42;Amyloid beta-Protein;Animal Model;Animals;Attention;Biological;Biological Aging;Biological Markers;biomarker identification;Birth;Brain;Brain Pathology;Brain region;Caenorhabditis elegans;Cardiometabolic Disease;Cell Aging;Clinical Trials;Cognition;Cognition Disorders;Cognitive;cognitive control;cognitive function;cohort;Data;Dementia;Development;Dimensions;Discrimination;DNA Methylation;early detection biomarkers;Early identification;Early Intervention;early life stress;emerging adult;emotion dysregulation;emotion regulation;emotional functioning;epigenetic clock;Etiology;executive function;Female;flexibility;Functional Magnetic Resonance Imaging;functional outcomes;Funding;Goals;Health;healthy aging;Hippocampus;Human;hypothalamic-pituitary-adrenal axis;Impaired cognition;infancy;Inflammation;innovation;interest;Intervention;Invertebrates;Kynurenine;late life;Length;Life;life span;Link;longitudinal design;Longitudinal Studies;longitudinal, prospective study;Macaca;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;mathematical methods;Measures;Mediating;Memory;men;Mental disorders;Methods;middle age;Modeling;Myelin;N-acetylaspartate;Nervous System Disorder;neural;Neurocognitive;neuroinflammation;neuropathology;neuroprotection;neurotoxic;neurotoxicity;nonhuman primate;novel;Outcome;Pathway interactions;Population;Predictive Factor;Prefrontal Cortex;Primates;prospective;Puberty;Quinolinic Acid;relational memory;Reporting;Research;resilience;Rest;Risk;Risk Factors;Rodent;social;social group;spatial memory;Statistical Methods;Statistical Models;statistics;Stress;Stress Tests;Synapses;Task Performances;tau Proteins;Telomere Shortening;Testing;Therapeutic;Thinness;Time;United States National Institutes of Health;Woman;young adult

PROJECT_TITLE: Early risk factors of accelerated neural aging trajectories and cognitive decline: a nonhuman primate longitudinal model

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: DREXEL UNIVERSITY

PHR: PROJECT NARRATIVE  We will systematically engage local policy, community, and academic stakeholders to develop and refine a dynamic conceptual framework that elucidates drivers of racial/ethnic disparities in diet in cities. We will also implement an agent-based simulation model to examine how high levels of racial/ethnic residential segregation in U.S. cities, the inequitable distribution of food outlets, pervasive income inequality, and the lower price of energy-dense, non-nutritious foods relative to healthier foods work in combination to constrain healthy food choices of racial/ethnic minorities and lead to disparities in diet and obesity. We will use the model to evaluate how inequitable job and income loss due to the COVID-19 pandemic will affect diet disparities, and how multiscale federal, state, and local policies can either exacerbate or reduce disparities.

PI_NAMEs: LANGELLIER, BRENT ALAN (contact)

PROGRAM_OFFICER_NAME: PATEL, ANURADHA DIPAK

PROJECT_TERMS: Address;Affect;Asian;Behavioral;Beverages;Black Populations;Black race;Body Weight Changes;Budgets;Buffers;Calibration;Categories;Charge;Cities;Communities;Complex;cost;COVID-19 pandemic;data standards;Diet;Dietary Fiber;Disadvantaged;Disparity;disparity reduction;Eating;Economic Conditions;economic impact;Eligibility Determination;Enrollment;Environment;Equipment and supply inventories;ethnic disparity;ethnic minority;Ethnic Origin;farmers markets;Federal Government;federal policy;Food;Food Access;Food Assistance Programs;food insecurity;Food Preferences;General Population;Grain;Harvest;Health Food;high risk;Household;Immigrant;Income;Individual;Inequality;inequitable distribution;Inequity;Latino;Latino Population;Lead;Legal;Life;Low income;Maps;Methods;Minority;model building;Modeling;models and simulation;Neighborhoods;nutrition;Nutritional;Obesity;obesogenic;Occupations;Oils;outcome disparities;Participant;Pattern;Philadelphia;Policies;Policy Making;Poverty;Prevalence;Price;programs;Proteins;Psyche structure;Race;racial disparity;racial minority;Reducing diet;Reporting;Research;residential segregation;scale up;segregation;Series;simulation;social;social disparities;System;Thinking;Time;Travel;Unemployment;United States Department of Agriculture;urban area;urban setting;Variant;Vegetables;virtual;Work

PROJECT_TITLE: Complex systems approaches to identify policy levers to reduce racial/ethnic disparities in diet and obesity in cities

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Prevention;Sleep Research

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Relevance Up to 40% of adults with type 1 diabetes have insufficient sleep which is associated with negative health consequences including poor blood glucose control and greater diabetes complications. We propose a sleep intervention (Sleep-Opt) that uses wearable sleep tracking technology, telephone coaching and informational content designed to improve sleep and glycemic control in working-age adults with type 1 diabetes. Sleep-Opt could lead to reduced development of diabetes complications and improve quality of life for adults with type 1 diabetes.

PI_NAMEs: MARTYN-NEMETH, PAMELA ANN (contact)

PROGRAM_OFFICER_NAME: SILVA, CORINNE M

PROJECT_TERMS: actigraphy;Adult;Affect;Aftercare;Age;American;Attention;attentional control;Behavior;behavior change;Behavior Therapy;Behavioral;behavioral outcome;behavioral sleep intervention;Blood Glucose;blood glucose regulation;Caring;Circadian desynchrony;Clinical Trials;comparison intervention;Complications of Diabetes Mellitus;Continuous Glucose Monitor;Control Groups;Cross-Sectional Studies;Data;design;Development;diabetes distress;Diabetes Mellitus;diabetes self-management;Disease;Distress;efficacy evaluation;Elements;Eligibility Determination;Evaluation;Fasting;Fatigue;Glucose;glycemic control;Goals;group intervention;Health;Hour;improved;improvement on sleep;Individual;Insulin Resistance;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;interest;Intervention;Knowledge;Link;Measures;Medical;Mission;Monitor;Moods;Motivation;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Outcome;Participant;Patient Outcomes Assessments;Patient Self-Report;Patients;Persons;Pilot Projects;Prevention;primary outcome;programs;psychological outcomes;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;Research;Research Personnel;Research Support;Running;secondary outcome;Self Management;Sleep;Sleep Deprivation;sleep quality;sleep regulation;smartphone application;Strategic Planning;Technology;telephone coaching;Time;Treatment Protocols;wearable device

PROJECT_TITLE: Sleep optimization to improve glycemic control in adults with type 1 diabetes

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Pediatric;Social Determinants of Health

ORG_CITY: SILVER SPRING

ORG_NAME: WALTER REED ARMY INSTITUTE OF RESEARCH

ORG_STATE: MD

PHR: Project Narrative The fields of science, technology, engineering, and mathematics (STEM), are deeply impacted by educational disparities and inequities in the US public school. Our objective in this proposal is to disseminate sustainable near-peer mentor-led science enrichment programs within underserved high school classrooms through university partnerships. The proposed work will help establish the near-peer mentor model as a way to address systemic inequities in STEM education and increase the capacity for recruitment of students from underrepresented backgrounds into STEM internships at our and partnering institutions.

PI_NAMEs: YOURICK, DEBRA LYNN (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Address;Affect;after-school program;aspirate;Attitude;Behavioral;career;Cognitive;college;College Preparation;Communication;Communities;comparison group;Complement;Data;design;Disparity;dissemination strategy;Education;Educational process of instructing;efficacy evaluation;Elements;Emotional;Evaluation;evidence base;experience;Feedback;Fostering;Goals;Grant;Growth;high school;High School Student;Home;implementation fidelity;improved;Individual;Inequity;Institution;Internships;Knowledge;laboratory experience;Lead;Learning;Life;Low income;Maryland;Measures;mentoring community;Mentors;Mentorship;Minority;Modeling;Motivation;Neighborhoods;online community;optimism;outreach program;Participant;Pathway interactions;peer;peer coaching;Performance;Plants;Positioning Attribute;Postbaccalaureate;Program Sustainability;programs;racial minority;Research;Resources;Schedule;school district;Schools;Science;Science Enrichment;Science, Technology, Engineering and Mathematics;Science, Technology, Engineering and Mathematics Education;Scientist;Secondary Schools;Self Efficacy;Site;social;STEM career;STEM field;STEM student;student participation;Student recruitment;Students;summer program;Surveys;System;Techniques;Testing;Time;tool;Training;undergraduate student;Underrepresented Populations;Underrepresented Students;underserved community;Underserved Population;underserved students;United States;Universities;virtual;Vision;Work

PROJECT_TITLE: Facilitating sustainable partnerships for STEM education and accessible pathways for STEM students using an evidence-based model

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]


NIH_SPENDING_CATS: Cardiovascular;Contraception/Reproduction;Genetics;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

PHR: Narrative: The proposed research focuses on improving our understanding of the role of maternal genetic factor ET-1 in PE, especially its effects on the embryo-maternal interface, and the mechanism of Nam protecting against the detrimental effects of elevated ET-1 levels observed in PE. In defining such factors/pathways involved in the functions of ET-1 during PE and the possible interactions with Nam, potential preventive and/or therapeutic strategies for PE may result, which could improve short- and long-term health outcomes of mothers and their offspring. Thus, the proposed research is relevant to the part of the NIH mission of reducing illness and disability.

PI_NAMEs: LI, FENG  (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: 3-Dimensional;Abnormal placentation;Affect;Albumins;Amides;angiogenesis;Angiogenesis Inhibitors;Angiogenic Factor;Blood Pressure;Blood Vessels;Cell Differentiation process;Cells;Code;Coitus;Conditioned Culture Media;Cone;Data;Decidual Cell Reactions;Development;Differentiation Antigens;disability;Disorientation;Dissociation;Dose;drinking water;Embryo;Endometrial;Endometrial Stromal Cell;Endothelin-1;Excretory function;fetal;Fetal Growth Retardation;Fetus;Genes;Genetic;genetic association;Genetic Markers;Genetic Polymorphism;Genotype;Health;Human;hypertensive;Impairment;implantation;improved;in vivo;inhibitor;insight;Intervention;Invaded;Late Effects;Late pregnancy;Link;maternal morbidity;Maternal Mortality;maternal outcome;maternal serum;Mediating;Mediator;Medical;Messenger RNA;Mission;Molecular;Morphology;mortality;Mothers;Motility;mouse model;Mus;natural Blastocyst Implantation;neonatal morbidity;Niacinamide;offspring;Organ;Outcome;overexpression;Oxygen;Pathogenesis;Pathway interactions;Peptides;perinatal morbidity;Peripheral;pharmacologic;Phenotype;Placenta;Placentation;Play;Pre-Eclampsia;Pregnancy;pregnancy hypertension;Pregnancy Outcome;pregnant;Premature Birth;prevent;Prevention strategy;Preventive;Proteins;Proteinuria;receptor;Reporting;Research;Risk;Role;Side;Single Nucleotide Polymorphism;Site;small molecule;stem;stem cell differentiation;Stromal Cells;Structure;Symptoms;System;Testing;Therapeutic;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;treatment strategy;trophoblast;trophoblast stem cell;two-dimensional;ubiquitin-protein ligase;United States National Institutes of Health;urinary;Uterus;Vascular Endothelial Growth Factors;Villous;Viral;Vitamins;Weight;Work

PROJECT_TITLE: Benefits of nicotinamide in placental development and in preeclamsia

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Infectious Diseases;Prevention;Social Determinants of Health

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: PROJECT NARRATIVE The proposed study is an evaluation of a housing intervention, Operation Safer Ground, that was quickly implemented in response to the risk of COVID-19 among people experiencing homelessness. We will use qualitative methods to describe the development and implementation of the program, define its operational characteristics, and investigate contextual factors; we will use quantitative methods to see what happened over time among program participants and nonparticipants. The proposed study will provide information to improve the long-term response to the COVID-19 pandemic and help us prepare to protect vulnerable populations in future public health crises.

PI_NAMEs: COMFORT, MEGAN L;LORVICK, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Address;Affect;Age;arm;Behavioral;behavioral outcome;Black, Indigenous, People of Color;Caring;Characteristics;Chronic Disease;Client;Collaborations;Communities;community based research;community intervention;comparison group;Complex;Consolidated Framework for Implementation Research;contextual factors;coronavirus pandemic;County;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 risk;COVID-19 susceptibility;Data;Data Set;Databases;Development;Evaluation;Event;experience;Future;group intervention;Health;health care service;health care service utilization;health definition;health disparity;health disparity populations;Health protection;Healthcare;Home;Homeless persons;Homelessness;Housing;Human;human old age (65+);implementation framework;Imprisonment;improved;Individual;infection risk;Intervention;Interview;Knowledge;Mediation;Medicaid;Methods;mortality;multidisciplinary;Natural experiment;operation;Outcome;pandemic disease;Participant;Persons;Physician Executives;Population;Principal Investigator;Process;programs;Public Health;Qualitative Evaluations;Qualitative Methods;Quasi-experiment;Research;Research Personnel;response;Role;SARS-CoV-2 infection;Scoring Method;Services;social;social factors;social influence;Social outcome;Social Work;stem;structural determinants;Structure;substance use treatment;System;Time;transitional housing;transmission process;United States National Institutes of Health;vaccine acceptance;Vulnerable Populations

PROJECT_TITLE: Evaluation of Operation Safer Ground: A Community-Level Rapid Housing Intervention for People Vulnerable to COVID-19.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-H(58)R]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Digestive Diseases

ORG_CITY: LEXINGTON

ORG_NAME: PROTEAN BIO INC.

PHR: NARRATIVE Protean Bio has identified a novel peptide mimetic (D6PV) and the goal of the current study is to complete IND enabling studies to develop a therapeutic based on D6PV by conducting toxicology studies and manufacturing GMP drug substance and drug product for future Phase 1 trials in normal healthy volunteers. Successful completion of aims proposed here will result in the development of a novel therapeutic as an intravenous formulation with a rapid onset of action for the treatment of hospitalized patients with acute pancreatitis to reduce the length of stay in the hospital and reduce or eliminate the morbidity and mortality.

PI_NAMEs: DEVALARAJA, MATT  (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Acinar Cell;Acute;acute pancreatitis;Address;Adverse effects;Agonist;Alanine;analytical method;antagonist;Antibodies;Apolipoproteins;Apolipoproteins C;Binding;Canis familiaris;cell injury;Chylomicrons;Clinical Chemistry;Clinical Treatment;Clinical Trials;cost;design;Development;Diagnosis;Documentation;Dose;Drug Kinetics;Engineering;first-in-human;Formulation;Future;genotoxicity;Goals;Grant;healthy volunteer;Hematology;Histopathology;Hospitalization;Hospitals;Hour;Human;Hypertriglyceridemia;immunogenicity;in vivo;in vivo Model;innovation;Intensive Care;Intravenous;intravenous administration;lead candidate;Length of Stay;Lipolysis;lipoprotein lipase;Lipoproteins;manufacture;manufacturing process;manufacturing scale-up;Maximum Tolerated Dose;Methionine;Methodology;Methods;Modality;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mutant Strains Mice;Necrosis;No-Observed-Adverse-Effect Level;Nonesterified Fatty Acids;nonhuman primate;novel;novel therapeutics;Nucleic Acids;Organ;Organ failure;pain reduction;Pancreas;Patient Admission;Patients;Peptides;peptidomimetics;Pharmaceutical Preparations;Pharmacodynamics;Pharmacology;Phase;Phase I Clinical Trials;phase I trial;phase II trial;Phase II/III Trial;Placebos;Plasma;Positioning Attribute;preclinical study;prevent;Proline;Property;Proteins;Protocols documentation;Rattus;Regimen;Regulation;Report (document);Risk;Rodent;Safety;safety assessment;scale up;Specific qualifier value;systemic toxicity;Testing;Therapeutic;Therapeutic Agents;Toxic effect;Toxicology;Triglycerides;Validation;Valine;Very low density lipoprotein

PROJECT_TITLE: Development of D6PV- a novel ApoC-II peptide mimetic therapeutic


ADMINISTERING_IC: HG

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: Narrative To comprehensively understand the cellular states that drive biological function and pathology, it would be ideal to identify biomolecules in their spatial context within fixed cells and tissue by combining both imaging-based screening with omics-level profiling by next generation sequencing (NGS). We propose to develop a light- directed spatial barcoding platform for highly parallelized, deep profiling of individual cells transcriptomic states within user-defined areas of tissue and clinical samples.

PI_NAMEs: YIN, PENG  (contact)

PROGRAM_OFFICER_NAME: NOVA, IAN CURTIS

PROJECT_TERMS: Address;Adoption;Antibodies;Area;Atlases;Bar Codes;Biological;Biological Assay;Biological Process;Brain;cDNA Library;cell fixing;cell type;Cells;Clinical;combinatorial;Complex;cost effective;Data;Data Set;density;design;direct application;Dissociation;DNA;empowerment;flexibility;Fluorescent in Situ Hybridization;follow-up;Hand;Health;Human;Image;In Situ;in situ imaging;indexing;Individual;interest;Interstitial Cell of Cajal;Libraries;Light;Location;Maps;Methods;mixed cell culture;Morphology;Mus;Names;next generation sequencing;parallelization;Pathologist;Pathology;Population;Preparation;preservation;protein expression;Reaction;Research Personnel;Resolution;Retina;RNA;Sampling;screening;sequencing platform;Slide;Stains;Surface;System;Technology;technology platform;Time;Tissue Sample;Tissues;tool;Transcript;transcriptome;transcriptome sequencing;transcriptomic profiling;transcriptomics;Work

PROJECT_TITLE: Light-Seq: Spatially targeted profiling of transcriptomic states in cells and tissue

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ORG_CITY: DETROIT

ORG_DEPT: GENETICS

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative  Endoplasmic Reticulum (ER)-Associated Degradation (ERAD) is a major protein quality-control program that monitors and degrades unfolded or misfolded proteins. This project will define the function and mechanism by an unprecedented ERAD program regulates RNA modification and subsequent lipid metabolism under the circadian clock. The findings obtained from this project will open new paradigms for the studies on the physiological ERAD and RNA modification and shed new light on developing therapeutics for lipid-associated metabolic disorders, particularly non-alcoholic fatty liver disease (NAFLD) and hyperlipidemia.

PI_NAMEs: FANG, DEYU ;ZHANG, KEZHONG  (contact)

PROJECT_TERMS: Address;Animal Model;Apoptosis;Binding;Cellular Metabolic Process;circadian;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;cofactor;Cues;Cytosol;Degradation Pathway;Endoplasmic Reticulum;Enzymes;Fatty Liver;Genetic Engineering;Goals;Hepatic;High Fat Diet;Homeostasis;Human;Hyperlipidemia;knock-down;Knockout Mice;lipid metabolism;Lipids;Liver;Mediating;Messenger RNA;Metabolic;Metabolic Control;Metabolic Diseases;metabolic phenotype;Metabolism;Methylation;misfolded protein;Modification;Molecular;Monitor;mRNA Stability;mRNA Translation;Mus;non-alcoholic fatty liver disease;novel;Pathway interactions;Periodicity;Physiological;Physiological Processes;Play;Polyubiquitination;preservation;Process;programs;Proliferating;Protein Family;Proteins;Quality Control;Reader;Regulation;risk mitigation;RNA;Role;Signal Transduction Pathway;Testing;Therapeutic;Time-restricted feeding;Translations;ubiquitin-protein ligase;Ubiquitination

PROJECT_TITLE: Regulation of Rhythmic m6A RNA Modification by ER‐associated Degradation

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: RELEVANCE (See instructions): The L polymerase protein of nonsegmented negative-strand (NNS) RNA viruses contains an RNA dependent RNA polymerase and a suite of unconventional mRNA capping enzymes including a polyribonucleotidyltransferase and a dual-specificity cap methyltransfease. Understanding how those activities are controlled to ensure that the viral genome is expressed is of intrinsic interest and has the potential to impact the development of antiviral drugs and live attenuated vaccines. Here we will compare structural and functional insights into this protein for a prototype NNS RNA virus, vesicular stomatitis virus and the human pathogen rabies.

PI_NAMEs: WHELAN, SEAN PJ (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Anti-viral Agents;antiviral drug development;Attenuated Vaccines;attenuation;Award;Binding;Binding Proteins;Biochemical;Biochemistry;Biological Assay;Catalytic Domain;Complement;Complex;Cryoelectron Microscopy;Data;density;Dissociation;Electron Microscopy;Experimental Genetics;experimental study;fitness;Fluorescence Resonance Energy Transfer;fluorophore;Freezing;Funding;Genes;Genetic;genetic approach;Genetic Transcription;Genomics;Glycine decarboxylase;Grant;Hand;Helper Viruses;human pathogen;improved;In Vitro;in vitro Assay;insight;Instruction;interest;Label;Licensing;Maps;Measles;Messenger RNA;Methylation;Methyltransferase;microscopic imaging;Modeling;Molecular Virology;Movement;mRNA capping;mRNA guanylyltransferase;multiple myeloma M Protein;Mumps;mutant;Negative Staining;New Jersey;Nucleocapsid Proteins;Phosphoproteins;Poly A;Polymerase;polymerization;Polymers;Process;Production;promoter;Property;Proteins;prototype;Public Health;Rabies;rabies viral tracing;Rabies virus;Reaction;Recombinants;reconstitution;recruit;Regulation;replicase;Resolution;RNA;RNA chemical synthesis;RNA Processing;RNA replication;RNA Synthesis Inhibition;RNA Viruses;RNA-Directed RNA Polymerase;Role;Sampling;Series;single molecule;Site;Specificity;Structure;Testing;Textbooks;Time;Transcriptase;Vaccines;Vesicular stomatitis Indiana virus;vesicular stomatitis virus L protein;Viral;Viral Genome;Viral Matrix Proteins;viral RNA;Virion;Virus;Walking;Work;X-Ray Crystallography

PROJECT_TITLE: RNA Processing in Non-Segmented Minus-Strand RNA Viruses

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE (RELEVANCE STETAMENT) Liver diseases cause about 30,000 deaths annually in the US, and the progression of fatty liver (nonalcoholic steatohepatitis, NASH) is the most common cause of liver dysfunction worldwide. To date the factors that promote fat deposition in the liver and the transition from steatosis to NASH and cirrhosis in humans are unknown in specific human genetic backgrounds. One obstacle to study such pathological transition is the absence of appropriate human liver tissue model. Environmental (epigenetic) factors, and genetic disease drivers have been associated to the NAFLD development and progression. This project aims to improve public health by utilizing organ engineering technology and stem cell engineering to constitute mini-livers that mimic human fatty liver disease with success to determine the role and mechanism of NAFLD-high risk or protective genetic variants.

PI_NAMEs: NAGRATH, DEEPAK ;SOTO-GUTIERREZ, ALEJANDRO  (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Adult;alternative treatment;Animals;Cell Communication;Cell Culture Techniques;Cell model;cell type;Cells;Cessation of life;Chronic Disease;chronic liver disease;Cirrhosis;Clinical;comorbidity;Complex;Cues;Data;Deposition;Detection;Development;Diabetes Mellitus;Disease;Disease Progression;engineered stem cells;Engineering;Environment;Epidemic;Epigenetic Process;Evolution;Excision;fatty acid biosynthesis;Fatty acid glycerol esters;Fatty Liver;fatty liver disease;Fibroblasts;Fibrosis;Funding;Future;Gene Modified;Genetic;Genetic Diseases;Genetic Polymorphism;genetic variant;Goals;Hepatic Stellate Cell;Hepatocyte;Heterogeneity;High Prevalence;high risk;Histologic;histone modification;Human;human disease;Human Genetics;human induced pluripotent stem cells;improved;In Vitro;induced pluripotent stem cell;Inflammatory;Isotopes;knock-down;lifestyle factors;Link;lipidomics;Liver;Liver diseases;Liver Dysfunction;Liver Fibrosis;liver metabolism;Macrophage;manufacture;Mediating;Mesenchymal;Metabolic;Metabolic Diseases;Metabolic Pathway;metabolic profile;Metabolism;metabolomics;Modeling;Molecular;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;novel strategies;Obesity;Organ;Organ Culture Techniques;Organ Model;Outcome;Pathogenesis;Pathologic;Patients;Pharmacotherapy;Phenotype;Population;prevent;Preventive;Primary carcinoma of the liver cells;Process;Public Health;Rattus;Resources;response;Role;Single Nucleotide Polymorphism;SIRT1 gene;small hairpin RNA;Source;stem;stem cell model;stressor;success;System;Techniques;Technology;Testing;Therapeutic;Therapeutic Intervention;Time;Tissue Model;Tissues;Variant;Work

PROJECT_TITLE: Mini-Livers Derived from Human IPS Cells for Modeling Steatosis and Therapy

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ORG_CITY: SEATTLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE TRPV1-2 and TRPM2 ion channels are multimodal sensors that transduce a variety of signal modalities into electrical signals to allow cells to adapt to their changing environment. In this proposal, we will use a combination of patch-clamp electrophysiology and fluorescence lifetime imaging microscopy to measure the energetic coupling between the sensing modules and the channels’ gates and among different sensing modules to explain the molecular mechanisms by which environmental signals control the gating process.

PI_NAMEs: GORDON, SHARONA E (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Biology;Capsaicin;Cells;Chemicals;conformational conversion;Coupled;Coupling;Electrophysiology (science);Environment;fluorescence lifetime imaging;Goals;Heterogeneity;innovation;Integral Membrane Protein;Ion Channel;Ions;Lipids;Measures;Mechanics;Membrane;Menthol;Modality;Molecular;Molecular Conformation;multimodality;Natural Products;Nutrient;Optics;patch clamp;Process;protein function;Proteins;sensor;Signal Transduction;Stimulus;sulfated glycoprotein 2;System;Time;tool;TRP channel;TRPV1 gene

PROJECT_TITLE: Conformational Energetics and Heterogeneity to Reveal Gating Mechanisms of TRPV and TRPM Ion Channels

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Kidney Disease;Pediatric;Urologic Diseases

ORG_STATE: PA

PI_NAMEs: SHAIKH, NADER  (contact)

PROGRAM_OFFICER_NAME: MENDLEY, SUSAN RUTH

PROJECT_TERMS: accurate diagnosis;Acute Cystitis;acute pyelonephritis;Address;Affect;Age;aged;Antibiotics;antimicrobial;Bacteria;bacterial resistance;Bedside Testings;Biological Markers;Biological Specimen Banks;Bladder;Catheterization;Child;Classification;Clinical;Clinical Trials;Culture-independent methods;Cystitis;design;Development;Diagnosis;diagnosis standard;DMSA;Enrollment;Escherichia coli;Escherichia coli Infections;Exhibits;Fever;Future;Gender;genetic signature;Goals;Growth;Hour;IL8 gene;Image;Immunoassay;Incidence;indexing;individualized medicine;Infection;Infective cystitis;Inflammatory;Interferons;Interleukin-2;Interleukin-9;Kidney;kidney infection;LCN2 gene;leukocyte esterase;Measures;Medical center;Messenger RNA;Methods;Modeling;Neurogenic Bladder;neutrophil;novel;Organism;point of care testing;Population;predictive modeling;Prevalence;Protein Analysis;Proteins;Reference Standards;renal scarring;Research Personnel;Risk;RNA;RNA library;Sampling;Scanning;Severities;Site;Specificity;Specimen;stem;Subgroup;Testing;Time;Training;transcriptome sequencing;transcriptomics;treatment duration;Ultrasonography;ultrasound;United States;urinary;Urinary tract infection;Urine;Validation;Writing

PROJECT_TITLE: Biomarkers for Urinary Tract Infection and Pyelonephritis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-R(90)]


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Lung;Mental Health;Neurosciences;Obesity;Prevention;Sleep Research;Substance Misuse

ORG_CITY: BROOKLYN

ORG_DEPT: NEUROLOGY

ORG_NAME: SUNY DOWNSTATE MEDICAL CENTER

PHR: PROJECT NARRATIVE The Bklyn CRS of the MACS/WIHS CCS will address the unique and diverse characteristics of aging, urban, underrepresented men and women, and examine critical questions regarding clinical, behavioral, and epidemiological characteristics of HIV infection and associated comorbidities through follow-up of a cohort of men and women with HIV infection and matched seronegative controls. This platform will ultimately inform policy, treatment, and prevention approaches that will improve the health and well-being of men and women living and aging with HIV infection.

PI_NAMEs: GUSTAFSON, DEBORAH R. (contact);WILSON, TRACEY ELIZABETH

PROGRAM_OFFICER_NAME: PATHAK, ELIZABETH BARNETT

PROJECT_TERMS: Achievement;Address;adjudication;Adult;Affect;Age;Aging;aging brain;aging related;Area;Behavioral;Biological;Blood Vessels;Brain imaging;Cardiovascular Diseases;Cardiovascular system;career development;Caring;Central obesity;Cerebrovascular Disorders;Characteristics;Chronic;chronic infection;Chronic Obstructive Pulmonary Disease;Clinical;clinical research site;Cognition Disorders;cohort;Cohort Studies;community engagement;comorbidity;Coupled;Data;Data Collection;data quality/integrity;Dementia;Development;Elderly;Enrollment;Ensure;Epidemiology;experience;follow-up;Fostering;frailty;Genetic;Geographic Locations;Health;high standard;HIV;HIV Infections;Impaired cognition;improved;Infrastructure;innovation;Interdisciplinary Study;Leadership;Life Cycle Stages;Lung;Measures;men;Mental Depression;Mentors;Methods;middle age;Mission;Modeling;Molecular;Morbidity - disease rate;multidisciplinary;Neurocognition;Neurocognitive;Newly Diagnosed;next generation;Obesity;Older Population;Outcome;Participant;participant retention;Pathogenesis;Peripheral;Personal Satisfaction;Phenotype;Policies;Positioning Attribute;Prevention approach;Prospective cohort;protective factors;Protocols documentation;psychologic;psychosocial;pulmonary function;Reading;Recording of previous events;recruit;Research;Research Personnel;Resources;Risk;Risk Factors;Science;Scientist;Self Management;Sexual Health;Site;Sleep;sleep quality;sleep quantity;social;Spirometry;Stroke;substance use;Syndrome;Testing;Time;Training;vascular risk factor;Weight Gain;Woman;Women's Interagency HIV Study

PROJECT_TITLE: MACS/WIHS Combined Cohort Study: Brooklyn Clinical Research Site (Bklyn CRS)


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Orphan Drug;Precision Medicine;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: CHARLESTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PUBLIC HEALTH RELEVANCE STATEMENT: Allogeneic hematopoietic stem cell transplantation is a potentially curative therapy for many malignant diseases whose applicability has been impeded by the development of its most serious complication, acute graft versus host disease (aGVHD). Our goal is to develop clinically relevant strategies that validate prospectively biomarkers for aGVHD will allow for biomarker-based preemptive trial and better harnessing of treatment in many patients with hematological cancers. The fundamental insights gained from these studies will have broad and rapid implications to cancer therapy.

PI_NAMEs: PACZESNY, SOPHIE  (contact)

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: Acute Graft Versus Host Disease;adaptive immunity;Address;Allogenic;antagonist;Antibodies;Appearance;Binding;Biological;Biological Assay;Biological Markers;Biological Products;cancer therapy;CD28 gene;Cessation of life;Clinic;Clinical;clinical investigation;Clinical Research;Clinical Trials;clinically relevant;Complication;Correlative Study;curative treatments;Cytoprotection;Data;Dendritic Cells;design;Detection;Development;Disease;disease model;disorder prevention;Effector Cell;effector T cell;efficacy testing;Equilibrium;Fred Hutchinson Cancer Research Center;Future;gastrointestinal;Goals;graft vs host disease;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;Human;Immune;Incidence;Indiana;Inflammation;innovation;insight;Interleukin-2;Interleukins;Intervention;Intestines;Journals;Laboratories;Malignant - descriptor;MCAM gene;Measures;Mediating;Membrane;Molecular;Morbidity - disease rate;mortality;Multicenter Studies;Natural Immunity;neutralizing antibody;new therapeutic target;Newly Diagnosed;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Pathogenesis;Pathway interactions;patient stratification;Patients;Peripheral Blood Mononuclear Cell;Plasma;Population;post-transplant;Pre-Clinical Model;predicting response;preemptive intervention;prevent;Prognostic Marker;prophylactic;prospective;Prospective Studies;Proteome;Proteomics;public health relevance;Publishing;receptor;Recurrent disease;Regimen;Regulation;Regulatory T-Lymphocyte;Research;response;Risk;risk stratification;Safety;Sampling;Science;Severity of illness;specific biomarkers;Steroids;Stromal Cells;success;T-Lymphocyte;Testing;Therapeutic;therapeutic target;therapy resistant;Translating;translational medicine;Translational Research;Transplant Recipients;tumor;Universities

PROJECT_TITLE: Translating Novel Drug-Targetable Biomarkers to Treat Graft versus Host Disease

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Cancer Genomics;Cardiovascular;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Mental Health;Neurosciences;Prevention;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative The MACS and WIHS are major studies of the progression of HIV infection in men and women who are representative of the epidemic (e.g., racially and ethnically diverse, variable degrees of engagement in care) in the United States. The goal of the newly merged cohort is to study the “health span” of people living with HIV now. The relevance of the proposed research would be to contribute fundamental knowledge on the impact of factors (i.e., sex, race and ethnicity, somatic and gonadal aging, psychosocial, genetic) on HIV progression and risk for comorbid conditions (i.e., cardiovascular disease, cancer, neurocognitive impairment, and lung, kidney, liver and physical function changes).

PI_NAMEs: AOUIZERAT, BRADLEY E;PRICE, JENNIFER COHEN;TIEN, PHYLLIS C (contact)

PROJECT_TERMS: 3-Dimensional;Aging;Anti-Retroviral Agents;Area;Biological;biological sex;Blood Vessels;Brain;Cardiac;Cardiac Electrophysiologic Techniques;Cardiovascular Diseases;career;career development;Caring;Cells;Clinical;clinical research site;cognitive task;cohort;Cohort Studies;Collaborations;Communities;comorbidity;comparison group;cost effective;Data;Data Analyses;Disease;Electrocardiogram;Enrollment;Epidemic;Epigenetic Process;epigenomics;ethnic diversity;Ethnic Origin;Fibrosis;Funding;Generations;Genetic;genomic data;Genomics;Goals;healthspan;Hepatic;HIV;HIV Infections;Immune;Informatics;Injury;Kidney;Knowledge;Lead;Leadership;Leukocytes;Link;liver function;liver injury;Longitudinal Studies;Lung;Malignant Neoplasms;marginalization;Mass Spectrum Analysis;Measures;men;Mentors;Mentorship;Methods;Mid-Career Clinical Scientist Award (K24);Mitochondria;Morbidity - disease rate;Neurocognition;Neurocognitive;Neurocognitive Deficit;neuroimaging;novel;Organ;Outcome;Output;Ovarian aging;Participant;participant enrollment;Pathogenesis;Pathway interactions;Peripheral;peripheral blood;Persons;Pharmaceutical Preparations;Pharmacogenomics;pharmacologic;Pharmacology;Phenotype;Physical Function;Physiology;Population;Populations at Risk;Process;psychosocial;pulmonary function;Race;racial diversity;Recording of previous events;recruit;Renal function;Research;Research Personnel;Risk;San Francisco;Seminal;sex;skills;social group;Source;Specimen;Structure;Testing;Tissues;translational scientist;United States;United States National Institutes of Health;vascular injury;Woman;Women's Group;Work;working group

PROJECT_TITLE: SF Bay Area MACS/WIHS Combined Cohort Study


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lung;Mental Health;Neurosciences;Prevention;Social Determinants of Health;Substance Misuse;Women's Health Research

PHR: PROJECT NARRATIVE The scientific leadership and methods implemented by the Pitt/OSU CRS will enable the MACS/WIHS CCS to answer important questions relevant to treated HIV-infected MSM, the group with the highest HIV incidence in the US, and questions about the interaction of HIV and aging, important as the HIV-infected population shifts into older ages. The proposed research will provide information for development and administration of new interventions for HIV, as well as for the prevention of AIDS-defining and non-AIDS defining outcomes.

PI_NAMEs: MARTINSON, JEREMY JAMES;RINALDO, CHARLES R (contact)

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;adjudication;Adult;Affect;Age;Aging;aging biomarker;AIDS prevention;Anatomy;Anti-Retroviral Agents;Applications Grants;Back;Behavior;Behavioral;Biological;Blood;Body Composition;Brain;Brain imaging;Cancer Survivorship;cancer therapy;Cardiac;Cardiovascular system;career;career development;CD4 Positive T Lymphocytes;Cells;Censuses;cervicovaginal;Cessation of life;Characteristics;Chronic;Clinical;Clinical Management;clinical research site;Clonal Expansion;co-infection;Cognition;Cognitive;cognitive function;cohort;Cohort Studies;Collection;comorbidity;Complement;County;Data;Development;disability;Drug Exposure;Education;Elderly;End stage renal failure;Enrollment;Epidemic;Epidemiology;Event;falls;Feces;Female;Fostering;Fracture;frailty;Funding;Genetic;Genome;Guidelines;Hair;Health;health disparity;HIV;HIV Infections;HIV/AIDS;Hospitalization;human old age (65+);Immune;Immunologics;Immunosuppression;improved;Incidence;Income;Inequality;Infrastructure;innovation;insight;interest;Intervention;Laboratories;Lavage;Lead;Leadership;Life;Location;Lung;Lung Diseases;male;Malignant neoplasm of lung;Malignant Neoplasms;Measures;men;men who have sex with men;Metabolic;Methods;microbiome;Mission;molecular marker;mortality;Natural History;Neighborhoods;Neurocognitive;neuroimaging;novel;Ohio;older men;older women;Oral;Oral health;Outcome;Outcome Measure;Participant;participant enrollment;Pathogenesis;Pattern;Persons;pharmacologic;Phenotype;Physical Function;Plasma;Population;Poverty;prevent;Prevention;Protocols documentation;psychosocial;pulmonary function;Race;Request for Applications;Research;Research Personnel;Research Project Grants;resilience;Respiratory Signs and Symptoms;Risk;Risk Factors;Role;sex;Sleep;sleep quality;Specimen;Standardization;Stroke;Structure;Students;The Multicenter AIDS Cohort Study;Tissues;Tumor Tissue;United States;Universities;Urine;Viral Load result;Viral reservoir;Virus Latency;Woman;Women's Interagency HIV Study

PROJECT_TITLE: University of Pittsburgh MACS/WIHS CCS


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cancer;Cardiovascular;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Microbiome;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: The Bronx Clinical Research Site (CRS) will support the Combined Cohort Study (CCS) to understand and advance the study of comorbidities associated with HIV infection and its treatment, providing leadership in studies of cardiovascular disease, HPV, and metabolic conditions of aging. We will continue to follow our large numbers of well-characterized women currently enrolled in the Bronx Women's Interagency HIV Study, as well as recruit primarily racial and ethnic minority men and women with or at-risk for HIV to reflect the NYC HIV epidemic, and allow us to investigate the impact of age, sex, race/ethnicity, and health disparities on HIV-related comorbidities and HIV disease progression across the lifespan.

PI_NAMEs: ANASTOS, KATHRYN M.;HANNA, DAVID B.;SHARMA, ANJALI  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;adjudication;Age;age acceleration;Age disparity;age effect;Aging;antiretroviral therapy;Area;Baltimore;Bone Diseases;Caliber;Cardiovascular Diseases;cardiovascular imaging;Cardiovascular system;career development;Caring;Cervical;Cervical Cancer Screening;cervicovaginal microbiome;Chronic;clinical research site;cohort;Cohort Studies;Collaborations;Collection;Communities;comorbidity;Data;Data Analyses;Data Coordinating Center;data sharing;Development;Disease;Disease Progression;Drug Kinetics;Echocardiography;Education;Enrollment;Ensure;Epidemic;ethnic disparity;ethnic minority;Event;experience;falls;FarGo;fecal microbiome;female reproductive tract;flexibility;Fostering;Fracture;frailty;Functional impairment;Funding;Genetic;Guidelines;Health;health disparity;HIV;HIV Infections;Human papilloma virus infection;Human Papillomavirus;immune activation;Immunologic Factors;Inflammation;inflammatory marker;innovation;Institution;Investigation;Investigator-Initiated Research;Lead;Leadership;life span;Link;Longterm Follow-up;Malignant Neoplasms;Measures;men;Mentorship;Metabolic;Metabolic Diseases;Metabolism;metabolomics;Methods;Methylation;microbiome;microbiome research;microbiome specimens;Minority Men;Monitor;Morbidity - disease rate;mortality;Mucosal Immunity;Natural History;Neurocognitive Deficit;Obesity;oral microbiome;organizational structure;Outcome;Participant;Pathogenesis;patient retention;Persons;Play;Population;premalignant;Principal Investigator;Process;Productivity;Protocols documentation;Publications;racial disparity;racial minority;Reading;Recording of previous events;recruit;Research;Research Infrastructure;Research Personnel;research study;Resources;retention rate;Risk;Role;Science;Series;sex disparity;Site;Sleep disturbances;Specimen;success;System;Techniques;The Multicenter AIDS Cohort Study;translational study;treatment response;United States;United States National Institutes of Health;vaginal microbiome;vaginal mucosa;Visceral;Visit;Woman;Women's Interagency HIV Study;Work

PROJECT_TITLE: Clinical Research Sites for the MACS/WIHS Combined Cohort Study  (MACS/WIHS-CCS)


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Prevention;Social Determinants of Health

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The goal of the proposed research is to characterize the online food shopping behaviors and attitudes of low- income older adults, and increase their online fruit and vegetable purchases using strategies based on behavioral economics. These results will inform changes to federal nutrition assistance programs to support healthy food choices of low-income adults in online shopping environments and reduce disparities in chronic disease risk in an aging population.

PI_NAMEs: RUMMO, PASQUALE  (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Address;Adult;aged;Aging;aging population;Area;arm;Attitude;Behavior;Behavioral;behavioral economics;career;Chronic;Chronic Disease;Collaborations;Consumption;Data;Decision Making;design;Development;Diet;Dietary Fiber;dietary guidelines;discount;Disease;disorder risk;disparity reduction;Eligibility Determination;Environment;Epidemiology;Ethnic Origin;Expenditure;experience;experimental study;Exposure to;Food;Food Access;Fruit;fruits and vegetables;Funding;Gender;Goals;good diet;Growth;Health;Health behavior;Health Food;Healthy Eating;heuristics;high risk;high risk population;Household;human old age (65+);improved;Incentives;Income;Institution;Intake;International;Internet;Intervention;Literature;Low income;Low Income Population;male;Marketing;medical schools;meetings;Mentored Research Scientist Development Award;Mentors;Methods;Neighborhoods;novel;nutrition;Nutritional Science;older adult;online community;Online Systems;Participant;payment;Policy Maker;Population;preference;prevent;programs;Race;Randomized;Recommendation;recruit;Research;Research Methodology;Research Personnel;Resources;response;Risk;Risk Reduction;Sampling;Supermarket;Surveys;Testing;therapy design;Training;Training Programs;Vegetables;Visit;volunteer;Work

PROJECT_TITLE: Impact of Behavioral Economic Strategies on Low-Income Older Adults' Food Choices in Online Retail Settings

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


NIH_SPENDING_CATS: Anorexia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Eating Disorders;Health Services;Mental Health;Mental Illness;Nutrition;Prevention;Serious Mental Illness

ORG_CITY: LOUISVILLE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: PROJECT NARRATIVE This project will refine the Facing Eating Disorder Fears (FED-F) for anorexia nervosa (AN) relapse-prevention treatment designed to prevent relapse after discharge from acute treatment. We will assess the feasibility, acceptability, clinical efficacy, and target engagement of this treatment versus treatment as usual. The proposed research has significant public health relevance, as it will directly lead to a highly accessible and deployable treatment that can decrease AN relapse and the high societal burden associated with AN. The proposed research is relevant to NIH’s strategic aim 4.3 as it will lead to the creation of an innovative evidence- based service delivery model using technology that can be easily disseminated to communities in need during a critical period of transition of care.

PI_NAMEs: LEVINSON, CHERI ALICIA (contact)

PROGRAM_OFFICER_NAME: BURSTEIN, MARCY ELLEN

PROJECT_TERMS: acceptability and feasibility;Acute;acute care;Admission activity;Aftercare;Anorexia Nervosa;Anxiety;approach behavior;approach/avoidance behavior;avoidance behavior;Behavior;Behavior assessment;behavior change;Behavioral;care systems;Caring;Cessation of life;Chronic;Clinical;clinical efficacy;Cognitive;cognitive benefits;cognitive function;cognitive skill;Cognitive Therapy;Communities;cost;cost outcomes;critical period;Data;Disabling;Disease remission;Eating Disorders;Educational process of instructing;Ensure;Environment;evidence base;experience;Extinction;Face;feasibility testing;Feedback;Focus Groups;Food;Fright;Goals;habituation;hospital readmission;Hospitalization;Hospitals;improved outcome;Individual;innovation;Inpatients;Interoception;Intervention;Lead;Literature;Medical;medical specialties;Methods;Morbidity - disease rate;mortality;Neurobehavioral Manifestations;Outcome;outpatient facility;Outpatients;Pathology;Patient Discharge;Patient Self-Report;Patients;Play;Preparation;prevent;Prevention program;Provider;psychoeducation;public health relevance;Randomized, Controlled Trials;Recovery;Relapse;relapse prediction;relapse prevention;remote technology;Research;Role;Service delivery model;Services;skills training;social;social situation;Stimulus;symptomatology;Symptoms;System;Technology;Testing;therapy design;Time;Translating;Translations;treatment as usual;treatment center;United States National Institutes of Health;user-friendly;virtual;virtual delivery;virtual platform;virtual therapy;Weight;Weight Gain;weight restoration;Work

PROJECT_TITLE: Facing Eating Disorder Fears for Anorexia Nervosa: A Virtual Relapse Prevention Program Targeted at Approach and Avoidance Behaviors


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative Women with perinatal mood and anxiety disorders (PMAD) may suffer from barriers to treatment. We will use national Medicaid, private insurance, and survey data to examine disparities in negative utilization and delivery outcomes to determine patient, community, and societal characteristics associated with these outcomes. We will also convene an Expert Panel to assist in generating a guide to evidence-based policymaking for state PMAD planning, and based on interviews with state maternal and infant health and mental health policy officials, develop tailored recommendations to inform future policy and targeted interventions.

PI_NAMEs: ZIVIN, KARA  (contact)

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: Address;adherence rate;adverse birth outcomes;Affect;Ambulatory Surgical Procedures;Anxiety;Anxiety Disorders;Area;Asian;barrier to care;Black race;Budgets;Caring;Cesarean section;Characteristics;Clinical;clinical care;Collaborations;Communities;community-level factor;cost;County;COVID-19;COVID-19 pandemic;Data;Data Sources;Development;Diagnosis;Disease remission;Disparity;Disparity population;economic impact;Economics;Education;Emergency department visit;ethnic disparity;Ethnic Origin;Evaluation;evidence base;Family;Future;Geography;health care disparity;health care service utilization;Health Policy;Health Resources;Health Services Research;high risk;High Risk Woman;Hispanic;hospital readmission;improved;Income;Individual;Infant Health;innovation;Inpatients;Insurance;intergenerational;Intervention;Interview;Investigation;Light;Low income;Maternal Health;Maternal Mortality;Medicaid;Medical;Mental Depression;Mental Health;mental health policy;Mental Health Services;minority health;minority health disparity;Minority Health Research;Monitor;Mood Disorders;Mothers;multilevel analysis;National Institute on Minority Health and Health Disparities;neonatal health;NIH Program Announcements;Obstetric Delivery;Outcome;Patients;Patterns of Care;Performance;Perinatal;perinatal mental health;perinatal period;Pharmaceutical Preparations;Policies;Policy Maker;Policy Making;Populations at Risk;Postpartum Period;Pregnancy;Pregnancy Complications;pregnancy related death;Premature Birth;Privatization;programs;Provider;psychiatric comorbidity;Psychotherapy;Race;racial disparity;Recommendation;Research;Resources;retention rate;Risk Assessment;Rural;severe maternal morbidity;Socioeconomic Status;Structure;Subgroup;Suicide;Surveys;System;treatment and outcome;treatment of anxiety disorders;urban area;Variant;Visit;Woman;women's outcomes

PROJECT_TITLE: Disparities in utilization and delivery outcomes for women with perinatal mood and anxiety disorders (PMAD): groundwork for state policymaking

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Brain Disorders;Congenital Structural Anomalies;Neurodegenerative;Neurosciences;Osteogenesis Imperfecta;Parkinson's Disease;Pediatric;Rare Diseases

ORG_CITY: PISCATAWAY

ORG_DEPT: CHEMISTRY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Narrative The biological significance of fibrillar protein assemblies in both health and disease, makes understanding the molecular underpinnings of their interactions essential for intervention. Protein interactions with collagen fibrils are critical for healthy cellular function, while self-assembly of intrinsically disordered α-synuclein monomers leads to pathological oligomer and fibril formation associated with Parkinson’s Disease. Using an integrative set of biophysical tools combined with cellular assays, our studies will reveal mechanisms that underlie fibril-protein interactions and will inform design of therapeutics to encourage functional or discourage pathological interactions.

PI_NAMEs: BAUM, JEAN S (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Address;alpha synuclein;Amyloid;Architecture;Atomic Force Microscopy;Binding;Binding Sites;Biological;biological systems;Biology;biophysical analysis;biophysical tools;Biophysics;Cell Physiology;Cells;Cellular Assay;Collagen;Collagen Fibril;Complex;Computing Methodologies;Connective Tissue Diseases;Cryoelectron Microscopy;Defect;design;Disease;Disease Progression;Extracellular Matrix Proteins;Health;Homeostasis;Hour;Inherited;Integrins;Intervention;Link;Molecular;Molecular Conformation;monomer;Motion;Mutation;nanoscale;Nature;Neurodegenerative Disorders;NMR Spectroscopy;novel;novel therapeutic intervention;Osteogenesis Imperfecta;Parkinson Disease;Pathologic;Platelet aggregation;Play;Property;Proteins;Protocols documentation;Role;self assembly;solid state nuclear magnetic resonance;Specificity;Structure;Surface;Surface Properties;synucleinopathy;System;Techniques;Therapeutic;Time;Visualization

PROJECT_TITLE: Integrative NMR and biophysical studies of fibrillar protein assemblies in health and disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(55)R]