NIH_SPENDING_CATS: Biotechnology;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human;Substance Misuse

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: Project Narrative  Infants with neonatal abstinence syndrome (NAS) experience prolonged hospital stays and poor neurodevelopmental outcomes, in-part because of the lack of accurate, individualized, biologic assessments available to manage this increasingly common medical condition. The proposed study will define the molecular mechanisms that regulate the response to opioid withdrawal in the developing brain by focusing on three candidate microRNAs (let-7a, miR-146a, miR-192) that have been shown to respond to opioid exposure in animal models and adults, and are impacted in both my preliminary study of infants with NAS, and my human neural progenitor cell (NPC) design of opioid withdrawal. By determining the mechanism through which microRNAs impact NPC differentiation in opioid withdrawal, and determining whether exosomal salivary microRNA levels predict treatment dose and neurodevelopmental outcomes in infants with NAS, this study will enhance our knowledge of NAS-related biology and identify potential biomarkers that could improve medical care for this important medical condition.

PI_NAMEs: SULLIVAN, RHEA ELENA (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Acceleration;Admission activity;Adult;Affect;Age;Animal Model;Binding;Biological;Biological Assay;Biological Markers;Biology;Birth;Blood;Brain;Caring;Cell Maturation;Cell Survival;Central Nervous System;Cerebrospinal Fluid;Childhood;Clinical;Clinical assessments;Clinical Management;Collection;Complex;cost;Cranial Nerves;Cyclic AMP-Dependent Protein Kinases;cytate;Data;design;Doctor of Philosophy;Dose;Early Intervention;Enrollment;exosome;experience;Fellowship;fetal opioid exposure;Gene Expression Regulation;Genetic Transcription;Glial Fibrillary Acidic Protein;Hospitalization;Hospitals;Hour;Human;Hyperactivity;immunocytochemistry;Impairment;improved;In Vitro;Incidence;Infant;infant outcome;Knowledge;Length of Stay;Linear Regressions;Longitudinal cohort study;maternal opioid use;Measures;Mediating;Medical;Messenger RNA;MicroRNAs;Molecular;Morphine;mRNA Expression;mRNA Translation;Neonatal Abstinence Syndrome;nerve stem cell;neurodevelopment;Neurodevelopmental Deficit;neurogenesis;Neuroglia;neuron development;Neurons;Newborn Infant;novel therapeutics;Nucleic Acids;Oligodendroglia;Opiate Addiction;Opioid;opioid epidemic;opioid exposure;opioid withdrawal;Oropharyngeal;Outcome;Physiological;Polymerase Chain Reaction;potential biomarker;Prediction of Response to Therapy;Questionnaires;Race;Reader;Repression;response;Risk;RNA;Saliva;Salivary;sample collection;Serum;service intervention;sex;single-cell RNA sequencing;Source;stem cell differentiation;stem cell fate;Symptoms;System;Testing;tool;Transcript;Transfection;United States;Untranslated RNA;Withdrawal;Work

PROJECT_TITLE: Understanding the miRNA response to opioid withdrawal and their uses as potential biomarkers for neonatal abstinence syndrome


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Networking and Information Technology R&D (NITRD);Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The Genomics and Bioinformatics Core (Core C) provides a centralized resource that allows the Program Projects to harness powerful immunogenomic and epigenomic, bulk and single cell next generation sequencing technologies, computational/bioinformatics analyses, and cross-platform integration. The deployment of these cutting-edge technologies and integrative analyses will create important synergies and efficiencies in resource usage across the Program Project, and resolve the molecular and cellular landscape of the TME to facilitate the goal of achieving precision immunotherapy for pancreatic cancer.

PI_NAMEs: FERTIG, ELANA  (contact)

PROJECT_TERMS: analysis pipeline;ATAC-seq;Bioinformatics;bioinformatics pipeline;Biological;Biological Models;Biometry;Budgets;Cells;ChIP-seq;Clinical;Clinical Trials;Clone Cells;Collaborations;Complement;Computer Analysis;Computing Methodologies;Core Grant;Coupled;Cytometry;Data;Data Analyses;data integration;data modalities;Data Set;Dedications;digital pathology;Dimensions;Disparate;diverse data;Epigenetic Process;epigenetic regulation;epigenomics;exome sequencing;Foundations;Genetic Transcription;Genomics;Goals;high dimensionality;Human;human model;Human Resources;human tissue;Image;Immune;immune cell infiltrate;immune checkpoint;Immune response;Immune System Diseases;Immunogenomics;Immunotherapy;Infrastructure;Intervention;Malignant neoplasm of pancreas;Malignant Neoplasms;Measurement;Measures;Methodology;Methods;Modality;Molecular;multidimensional data;multimodal data;multiplexed imaging;Mutation;Myeloid Cells;neoantigens;next generation sequencing;novel;novel strategies;novel therapeutic intervention;Outcome;Pancreatic Ductal Adenocarcinoma;Pathway interactions;Pattern;Peripheral;peripheral blood;personalized immunotherapy;pre-clinical;Program Research Project Grants;programs;protein profiling;Proteomics;Regimen;Research Personnel;Resistance;Resources;response;Shapes;single cell sequencing;single-cell RNA sequencing;synergism;T cell receptor repertoire sequencing;T-Cell Receptor;T-Lymphocyte;Techniques;Technology;Testing;Therapeutic;Tissues;Transcriptional Regulation;transcriptome sequencing;transfer learning;Treatment Protocols;tumor;tumor microenvironment;Tumor Tissue;Universities;Vaccines

PROJECT_TITLE: Core C: Genomics and Bioinformatics


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: NORMAN

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA

ORG_STATE: OK

PHR: Project narrative At the molecular level, the homeostasis of cells and tissues largely depends on the correct activity of properly structured proteins, that if altered can lead to the onset of a myriad different human diseases. With this research program we will develop new mass spectrometry technologies for the analysis of intact protein forms, or proteoforms, and their bioactive complexes, to elucidate the precise set of genetic and chemical modifications responsible for aberrant phenotypes in the human population. These new analytical tools will help advancing our understanding of the mechanisms underlying human pathologies and facilitate the identification of new biomarkers.

PI_NAMEs: FORNELLI, LUCA  (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: analysis pipeline;analytical tool;Biological;Biological Markers;biomarker identification;Biomedical Research;Cells;Chemicals;Chemistry;Complex;Cysteine;Detection;Disease;disease diagnostic;experimental study;Gases;Genetic;Higher Order Chromatin Structure;Homeostasis;Human;human disease;Human Pathology;improved;in vivo;innovation;insight;interest;Ions;Link;Mass Spectrum Analysis;Measurable;Measures;Medical;Modernization;Modification;Molecular;Molecular Machines;Monitor;neglect;next generation sequencing;novel;Onset of illness;Peptides;Phase;Phenotype;Population;Positioning Attribute;Post-Translational Protein Processing;preservation;programs;protein complex;Proteins;Proteome;Proteomics;Reaction;Research;Research Personnel;Shotguns;Structural Biologist;Structure;Techniques;Technology;Tissues;tool;Variant;Vision

PROJECT_TITLE: A multi-level mass spectrometry pipeline for the analysis of whole proteoforms and their complexes


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: NARRATIVE: The COMMUNITY Center of NYC brings together an interdisciplinary team of investigators, health care providers and community stakeholders around NYC through multi-institutional partnerships (Columbia, Cornell, New York Presbyterian Hospital, Physician Affiliate Group of New York) to reduce health disparities in multiple chronic diseases. We focus on cardiovascular disease and cancer, and their risk factors, as they are the two leading causes of death and that share common social context, etiological pathways, risk factors and management strategies.

PI_NAMEs: COHN, ELIZABETH GROSS;HERSHMAN, DAWN ;PHILLIPS, ERICA ;SHIMBO, DAICHI ;TERRY, MARY BETH  (contact);WILLIAMS, OLAJIDE

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: Address;Adherence;behavioral and social science;biomedical informatics;Biomedical Research;Biometry;Black, Indigenous, People of Color;burden of chronic illness;burden of illness;Cardiometabolic Disease;Cardiovascular Diseases;care delivery;Cause of Death;Cessation of life;Chronic;Chronic Disease;Cities;clinical translation;Collaborations;Colorectal Cancer;Communicable Diseases;Communities;community center;community collaboration;community engagement;Community Health Aides;community organizations;community partners;County;COVID-19;data harmonization;Data Science;design;Development;Dimensions;Disease Outcome;Disparity;disparity reduction;Early Diagnosis;Economics;Enrollment;Environmental Science;epidemiologic data;Epidemiology;Equity;ethnic disparity;Ethnic Origin;Etiology;experience;Faculty;Family;food insecurity;Funding;Geographic Distribution;Goals;Grant;Group Affiliation;Health;health determinants;health disparity;health equity;health equity promotion;Health Personnel;Health Services;health training;Healthcare Systems;high risk;Hospitals;housing instability;implementation science;improved;Individual;Infrastructure;Institution;Insurance;Interdisciplinary Study;Intervention;Learning;Life;Life Expectancy;Malignant Neoplasms;Maps;Medical;Medical center;Methods;Mission;Modeling;mortality;multiple chronic conditions;National Institute on Minority Health and Health Disparities;Neighborhoods;New York;New York City;next generation;novel;Outcome;Participant;Pathway interactions;Personal Satisfaction;Persons;Physicians;Policies;Poverty;Premature Mortality;Presbyterian Church;Prevention;Public Health;Public Policy;Race;Reduce health disparities;Reporting;Research;Research Personnel;Research Project Grants;Risk Factors;Risk Management;Science;segregation;Services;Sleep;sleep health;Social Environment;social health determinants;Societies;Structural Racism;System;Testing;Time;Training;training opportunity;Translational Research;Transportation;Universities;Vision;Voice

PROJECT_TITLE: Center to Improve Chronic disease Outcomes through Multi-level and Multi-generational approaches Unifying Novel Interventions and Training for health EquitY (The COMMUNITY Center)


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PI_NAMEs: VILLALTA, FERNANDO  (contact)

PROJECT_TERMS: Academic Medical Centers;Academic skills;Acceleration;Address;Affect;African American;African American population;Applications Grants;Award;Behavioral Research;behavioral study;Biomedical Research;career;career development;Chronic Disease;Clinical Research;Collaborations;Communities;community engaged research;community engagement;Creativeness;Data;Data Science;design;Development;Development Plans;disease disparity;disorder prevention;Disparity;Doctor of Philosophy;early-career faculty;Ensure;Equity;Evaluation;experience;Extramural Activities;Faculty;Feedback;Fostering;Funding;Funding Agency;Funding Opportunities;Goals;Grant;health determinants;Health Disparities Research;health disparity;health equity;Health Professional;Incidence;Infrastructure;innovation;Institution;International;Latino;Latino Population;Lead;Leadership;Link;Manuscripts;medical schools;meetings;Mentors;Mentorship;Mission;Modeling;Morbidity - disease rate;mortality;National Institute on Minority Health and Health Disparities;next generation;outreach;Participant;Periodicals;personalized medicine;Population;Postdoctoral Fellow;Precision Health;precision medicine;programs;Publications;recruit;Research;Research Personnel;Research Project Grants;Research Support;Research Training;Resource Development;Resources;Science;Series;skill acquisition;skills;success;Technology;Training;Translational Research;United States National Institutes of Health;Universities;Work;working group;Writing

PROJECT_TITLE: Investigator Development Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Pancreatic Cancer;Rare Diseases

PHR: PROJECT NARRATIVE The Digital Pathology and Mass Cytometry Core (Core D) will serve as a centralized resource for each project by providing state-of-the-art proteomic technologies to assay the status of the tumor microenvironment. The Core will employ multiple color image analysis (multispectral immunofluorescence tissue staining) and high- parameter single-cell protein profiling (mass cytometry by Time-of-Flight; CyTOF) of human and animal pancreatic tumor tissue in order to construct a multi-dimensional map of the tumor microenvironment.

PI_NAMEs: ANDERS, ROBERT A. (contact)

PROJECT_TERMS: Animals;anti-cancer research;Bar Codes;Bioinformatics;Biological;Biological Assay;biomarker panel;Biopsy Specimen;cancer immunotherapy;Cells;Clinical;Collaborations;Color;Communities;Complex;Comprehensive Cancer Center;Cytometry;Data;data acquisition;Data Set;Dedications;design;Development;digital pathology;Dimensions;empowerment;Ensure;Equipment;Fibroblasts;Flow Cytometry;Formalin;Generations;Genetic Transcription;Goals;Grant;high dimensionality;Histopathology;Housing;Human;Human Resources;Image Analysis;Imaging Techniques;Immune;Immune response;Immune System Diseases;Immunofluorescence Immunologic;Immunohistochemistry;Immunotherapeutic agent;Infrastructure;Institution;Internet;Laboratories;Link;liquid crystal polymer;Location;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;Methodology;Methods;Microscope;mid-career faculty;Molecular Profiling;multimodality;multiplexed imaging;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Oncology;Operative Surgical Procedures;Outcome;Pancreatic Ductal Adenocarcinoma;pancreatic neoplasm;Paraffin Embedding;Pathologist;Pathology;Physicians;Postdoctoral Fellow;Productivity;professor;Program Research Project Grants;programs;protein biomarkers;protein profiling;Proteins;Proteomics;quality assurance;Quality Control;Research;Research Personnel;Research Project Grants;Resolution;Resources;response;Rest;Sampling;Scanning;Scientist;single cell proteins;single-cell RNA sequencing;Stains;stem;success;Suppressor-Effector T-Lymphocytes;Suspensions;System;T cell receptor repertoire sequencing;T-Lymphocyte;targeted treatment;Technology;technology validation;Time;Tissue Sample;Tissue Stains;Tissues;tool;Training;translational study;tumor;tumor immunology;tumor microenvironment;Tumor Tissue;tumor-immune system interactions;Validation;Western Blotting;Work

PROJECT_TITLE: Core D: Digital Pathology and CyTOF


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: CARRASQUILLO, OLVEEN  (contact)

PROJECT_TERMS: Acceleration;adaptive intervention;Address;Adoption;African American;Behavior;Behavioral;Biological;Cardiovascular Diseases;Chronic Disease;Clinical;Collaborations;collaborative approach;Communities;community advisory board;community center;community engaged intervention;community engagement;community organizations;community partners;coping mechanism;culturally appropriate intervention;Data;data harmonization;Decision Making;Development;Diabetes Mellitus;Discipline;Discrimination;disease disparity;Disparity;Ensure;Environment;Equity;experience;Faculty;family support;Federally Qualified Health Center;Fostering;Framework Regions;Genetic;Glycosylated hemoglobin A;Goals;Health;health disparity;health equity;health equity promotion;Health Insurance;Health Resources;Health Services Accessibility;Health system;Healthcare Systems;Home;implementation science;improved;Infrastructure;innovation;Institution;Intervention;Latino;Measures;Mentors;mHealth;Obesity;Outcome;Patients;Personal Satisfaction;Pilot Projects;Policies;Precision Health;precision medicine;Process;Productivity;professional atmosphere;Psyche structure;Public Health;racism;Research;Research Personnel;Research Project Grants;Resources;Risk;Role;Rural Community;Science;Services;Sleep;social;social health determinants;Social support;Structural Racism;Structure;System;Time;Tobacco use;Translating;Trauma;Urban Community

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Data Science;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health

PI_NAMEs: TERRY, MARY BETH  (contact)

PROJECT_TERMS: Address;Adherence;Area;behavioral and social science;biomedical informatics;Biometry;burden of illness;Cardiometabolic Disease;Chronic Disease;Cities;clinical translation;college;Colorectal Cancer;Communities;community building;community center;community engaged research;Community Health Aides;data harmonization;Data Science;design;Development;Dimensions;Disease Management;Disease Outcome;disparity reduction;Economics;Enrollment;Ensure;Environmental Science;Epidemiology;Equity;Evaluation;Faculty;Feedback;food insecurity;Funding;Funding Mechanisms;Goals;Grant;Group Affiliation;health disparity;health equity;Health Policy;Health Services;health training;Healthcare Systems;Heart;high risk;Hospitals;housing instability;implementation science;improved;Individual;Infrastructure;Insurance;Intervention;Intervention Studies;Learning;Malignant Neoplasms;Medical center;meetings;member;Methods;Mission;Modeling;Monitor;National Institute on Minority Health and Health Disparities;New York;New York City;novel;Participant;Persons;Physicians;Pilot Projects;Presbyterian Church;Prevention;programs;Public Policy;Reduce health disparities;Research;Research Personnel;Resources;Science;screening;Services;Sleep;sleep health;social health determinants;synergism;System;Testing;Training;Translating;Translational Research;Transportation;Universities;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: TR

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE The Mayo Clinic Center for Clinical and Translational Sciences (CCaTS) accelerates innovations in clinical research and partners with our stakeholders and communities to improve patient care and human health for all people. It supports scientists who bring new discoveries to clinical practice, trains a diverse multidisciplinary workforce prepared to address the urgent health care needs of all communities in a rapidly changing environment and works closely with other research centers across the country to share innovative approaches. Project Narrative Page 290

PI_NAMEs: ENDERS, FELICITY T. B.;WINDEBANK, ANTHONY JOHN (contact)

PROGRAM_OFFICER_NAME: NAGEL, JOAN DAVIS

PROJECT_TERMS: Acceleration;Address;Advocate;base;Caring;Classification;Clinic;Clinical and Translational Science Awards;clinical center;clinical practice;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communities;community engagement;community partners;Competence;Country;COVID-19;COVID-19 pandemic;digital;digital health;Education;Elements;Environment;equity, diversity, and inclusion;Event;Faculty;Funding;Goals;graduate student;Health;health care service organization;health disparity;health equity;health equity promotion;health inequalities;Health system;Healthcare;Human;improved;Incubators;Individual;Informatics;innovation;Institution;Interdisciplinary Study;interest;Investments;Justice;Knowledge;Leadership;Learning;medical schools;Medical Students;member;Methodology;Methods;Minnesota;Mission;multidisciplinary;National Center for Advancing Translational Sciences;novel;operation;pandemic disease;Patient Care;Patients;Persons;Population;Positioning Attribute;Postdoctoral Fellow;Process;programs;Research;Research Personnel;Resources;response;Role;Rural Population;Scientist;Secure;social disparities;Structural Racism;synergism;Talents;Technology;theories;tool;Training;Training and Education;Translational Research;Translations;Trust;underserved community;United States National Institutes of Health;Vision;Work

PROJECT_TITLE: Mayo Clinic Center for Clinical and Translational Science (CCaTS)


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: STANFORD

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Mental disorders affect one in four people worldwide; however, the lack of quantifiable metrics for mental health disorders contributes to the challenges of diagnosis, monitoring, and treatment. The goal of this research proposal is to develop a skin-like wearable sensor system to monitor physical and chemical mental health biomarker as an approach to quantify mental health state. I will design and fabricate physical biosensors to monitor skin conductance and chemical biosensors to monitor sweat cortisol levels, using intrinsically stretchable materials to provide high signal-to-noise ratio recordings and minimal discomfort without social stigma.

PI_NAMEs: ZHAO, CHUANZHEN  (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: Acute;acute stress;Affect;Anxiety;aptamer;Behavioral Sciences;bioelectronics;Biological Markers;Biosensing Techniques;Biosensor;Body Temperature;Cardiovascular Diseases;career;Chemicals;Chronic stress;Circadian Rhythms;Clinical;cost;Data;Data Collection;data exchange;design;Detection;Development;Device Designs;Devices;Diagnosis;DNA;Electrical Engineering;Electrodes;Environment;experience;fabrication;Feedback;flexibility;Galvanic Skin Response;Glucose;Goals;Health Personnel;Health Services Accessibility;Health Status;high risk;Hormones;Hospitals;Human body;human subject;Hydrocortisone;Hydrogels;Immune response;Individual;insight;Knowledge;Measurable;Measurement;Measures;Mental Depression;mental disorder prevention;Mental disorders;Mental Health;Mental Health Services;mental state;Mentors;Molecular Conformation;Monitor;monitoring device;Morphologic artifacts;Motion;multimodality;National Institute of Biomedical Imaging and Bioengineering;new technology;Noise;novel;Patients;personalized health care;Persons;Physiological;post-doctoral training;prevent;Prevention;printed circuit board;professor;Psychiatry;psychobiologic;real world application;Research;Research Project Grants;Research Proposals;Resources;response;Scientist;Secure;sensor;Signal Transduction;skills;Skin;social;social stigma;Stigmatization;Stress;stress state;stressor;System;Techniques;Technology;technology platform;Testing;Time;tool;Training;Transistors;Translations;Universities;wearable device;wearable platform;wearable sensor technology;wireless;wireless electronic;wireless sensor;Work

PROJECT_TITLE: Skin-like wearable biosensors for multimodal mental health biomarker monitoring

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Recovery Support Services;Social Determinants of Health;Substance Misuse;Telehealth;Tobacco;Tobacco Smoke and Health

PI_NAMEs: HECKMAN, BRYAN WAYNE (contact)

PROJECT_TERMS: Abstinence;Acceleration;adaptive intervention;Address;Adherence;Affect;Attenuated;Behavioral;Biochemical;Black Populations;Black race;Cellular Phone;Chronic;Chronic Disease;Communities;craving;Creativeness;Cues;Data;design;Diabetes Mellitus;Diagnostic;digital intervention;disease diagnosis;disease disparity;disparity gap;diversity and inclusion;Ecological momentary assessment;effective therapy;Effectiveness;Effectiveness of Interventions;effectiveness testing;Environment;Equity;ethnic minority;Ethnic Origin;Evidence based treatment;Fatigue;Funding;Global Positioning System;Goals;Health;health care availability;Health Care Costs;health disparity;health equity;Health Services Accessibility;high risk;Individual;innovation;intelligent algorithm;Intervention;Laboratories;Life;Location;Mediator;meetings;mHealth;Modeling;mortality;multiple chronic conditions;National Institute of Drug Abuse;neglect;nicotine replacement;Obstructive Sleep Apnea;Patients;Pattern;personalized approach;personalized intervention;personalized medicine;Pharmacotherapy;Poverty;Prevalence;prevent;Race;racial disparity;racial minority;Randomized, Controlled Trials;Recommendation;Relapse;relapse prevention;relapse risk;Research;resilience;Risk Factors;Sampling;Self Efficacy;Severities;Smoke;Smoker;Smoking;smoking cessation;smoking intervention;smoking relapse prevention;success;technology platform;Testing;theories;therapy adherence;Time;time use;tobacco control;Tobacco Dependence;Tobacco smoking behavior;Treatment Efficacy;Underserved Population;usability;Vulnerable Populations;Withdrawal

PROJECT_TITLE: Accelerating Health Equity via Just-In-Time Adaptive Interventions (JITAIs):Scalable and High Impact mHealth Precision Smoking Relapse Prevention


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Microbiome;Neurosciences

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Errors in research are human and can provide us with valuable teachable moments to understand the why questions in science, i.e., the concepts underlying causality. The NeuR3o-LOGIC project uses a structured error analysis and reduction approach to teach critical thinking about causal relationships at the intersection of the human gut microbiome and the nervous system, particularly the brain. Expert interviews enhance recorded lectures and case study problems to illustrate the concepts through examples from related neurological disorders, such as autism.

PI_NAMEs: BOSCH, GUNDULA  (contact)

PROGRAM_OFFICER_NAME: CRAWFORD, DEVON CHRISTINE

PROJECT_TERMS: Administrative Supplement;Anatomy;autism spectrum disorder;Award;Awareness;Brain;Case Study;Categories;Cognitive;Communication;Community Networks;Community of Practice;Complement;Complex;Continuing Education;Critical Thinking;cultural values;Data Science;Databases;Decision Making;Dedications;Deposition;design;Discipline;Education;Education Projects;educational atmosphere;Educational process of instructing;Effectiveness;Elements;Ensure;Epidemic;Epistemology;Error Sources;Ethics;Etiology;Evaluation;experience;experimental study;flexibility;Foundations;Funding;Goals;gut microbiome;gut-brain axis;hands on research;Heart;Human;Hybrids;improved;innovation;Institution;Instruction;Interview;Knowledge;Learning;lectures;Literature;Logic;Mentors;Methods;microbiome research;Monitor;Names;Nervous System;Nervous System Disorder;Neurologic;Neurosciences;Neurosciences Research;Outcome;peer;Performance;Philosophy;Population Scientist Supplement (R25);Positioning Attribute;Process;Production;programs;Public Health;Public Health Schools;public trust;Publications;Reproducibility;Research;research in practice;Resources;Scholarship;Science;science education;Scientist;skills;sound;Source;Structure;Students;Testing;Thinking;Time;Training;Training Programs;Translating;undergraduate student;Validation;Work


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Neurosciences;Stroke

ORG_CITY: CHICAGO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: NARRATIVE Most stroke patients are initially evaluated at the closest hospital but some need to be transferred to a hospital that can provide more advanced care. The “Door-In-Door-Out” (DIDO) process at the first hospital can take time making transferred patients no longer able to get the advanced treatments. This study will help hospitals across the US “stand up” new ways to evaluate stroke patients, decide who needs to be transferred, and transfer them quickly for advanced treatment.

PI_NAMEs: HOLL, JANE LOUISE;PRABHAKARAN, SHYAM  (contact)

PROGRAM_OFFICER_NAME: BROWN, JEREMY

PROJECT_TERMS: Accident and Emergency department;Accounting;Acute;acute stroke;Adoption;Adult;Alteplase;Ambulances;Angiography;Blood Coagulation Disorders;Blood Pressure;Brain hemorrhage;care systems;Caring;Cause of Death;Cessation of life;Chicago;Clinical;Collaborations;collaborative approach;Consumption;Diagnostic;disability;Effectiveness;Electronic Health Record;Emergency Situation;Engineering;Ensure;Evaluation;evidence base;Exclusion;experience;Failure;Funding;Goals;Head;Health Care Costs;Health Services Research;Hospitals;Illinois;implementation evaluation;implementation framework;implementation measures;improved;Intervention;Intravenous;Ischemic Stroke;Learning;Location;Medicine;models and simulation;Myocardial Infarction;Neurologist;neurosurgery;novel;Outcome;Patient Transfer;Patients;Persons;Population;primary outcome;Process;Proliferating;prospective;Protocols documentation;Quality of life;randomized, controlled study;Renal function;Reperfusion Therapy;Research;Risk;Risk Assessment;satisfaction;screening;secondary outcome;simulation;Standardization;State Hospitals;Stroke;stroke patient;stroke therapy;System;telestroke;Testing;Time;tool;United States;United States Agency for Healthcare Research and Quality;user centered design;Work;X-Ray Computed Tomography

PROJECT_TITLE: Implementation of a Stroke Protocol for Emergency Evaluation and Disposition (HI-SPEED)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-W(02)M]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health

PROJECT_TERMS: Academia;Address;Affect;Behavior;burden of illness;Cardiovascular Diseases;Caring;Chronic;Chronic Disease;Cities;Clinical and Translational Science Awards;Collaborations;Communication;Communities;community center;community college;community engaged research;community engagement;Community Health;community organizations;Community Outreach;community partnership;connectome;design;Disease;Disease Outcome;Economic Conditions;Economics;Ecosystem;empowerment;Equity;Ethnic Origin;evidence base;Faith;Family health status;Fostering;Foundations;Funding Mechanisms;Goals;Grant;Group Affiliation;Health;health care delivery;health disparity;health equity;health equity promotion;health inequalities;Health Policy;Health Promotion;health training;Hospitals;improved;Individual;Infrastructure;Institution;Intervention;Learning;life span;Maintenance;Malignant Neoplasms;Measurable;Medical;Medical center;member;Methods;Minority-Serving Institution;Modeling;Names;Neighborhoods;New York;New York City;novel;outcome disparities;Patient-Focused Outcomes;Physical environment;Physicians;Policies;Population;Poverty;Prevention Research;Productivity;programs;Provider;Psyche structure;Race;Research;Research Institute;Research Personnel;Resources;safety net;Shapes;Signs and Symptoms;social;Social Environment;social health determinants;socioeconomics;Sociology;Stage at Diagnosis;Structural Racism;System;Time;Translating;Trust;United States;United States Agency for Healthcare Research and Quality;Universities;Vision;Voice;Work

PROJECT_TITLE: CONNECTOME-Community Engagement CORE


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Microbiome

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: The identity of bacterial species present in the human gut microbiome impacts human health; however, the factors determining which species colonize an individual remain poorly understood. This study is designed to identify antagonistic interactions occurring between species in the mammalian gut, with the goal of uncovering their contribution to gut microbiome species composition.

PI_NAMEs: SHEN, BETH A (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TITLE: Toxin neutralization to functionally dissect interbacterial antagonism in the gut microbiome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07B-U(20)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

PI_NAMEs: PUNJABI, NARESH M (contact)

PROJECT_TERMS: Accounting;Address;Adherence;Adult;adverse outcome;Affect;Age;arm;Attention;Behavioral;Beta Cell;black patient;Black Populations;Black race;Blood Pressure;blood pressure elevation;cardiometabolism;Cardiovascular Diseases;care costs;Caring;Cell Physiology;Chronic;Chronic Disease;clinical practice;cognitive performance;Communities;Community Health Aides;comorbidity;Comparison arm;Continuous Glucose Monitor;Coronary Arteriosclerosis;Data;Depressed mood;design;Diagnosis;Disease;disease disparity;Disparity in diagnosis;disparity reduction;Drowsiness;Dyslipidemias;Early Diagnosis;Early treatment;Effectiveness;Electronic Health Record;Equity;Ethnic Population;Fatigue;Federally Qualified Health Center;follow-up;functional status;Health;Health Care Costs;health care service utilization;health disparity;Health system;High Prevalence;Hispanic;Hispanic Populations;Home;Hour;Hypertension;Hypoxemia;Impaired cognition;Impairment;improved;Incidence;Individual;innovation;insulin sensitivity;Intervention;Medical;Minority Groups;motivational enhancement therapy;Newly Diagnosed;Non-Insulin-Dependent Diabetes Mellitus;Observational Study;Obstructive Sleep Apnea;Outcome;Outcome Study;Oxidative Stress;patient subsets;Patients;Pattern;positive airway pressure;Prevalence;Prevention;Provider;psychologic;Psychologist;Psychomotor Performance;Public Health;Quality of life;racial population;randomized, clinical trials;response;screening;screening program;Self Efficacy;Severities;sex;Sleep;Sleep Apnea Syndromes;Sleep Fragmentations;sleep health;social;social health determinants;Solid;Stroke;Subgroup;Sympathetic Nervous System;System;systemic inflammatory response;Testing;Training;trial comparing;underserved community;Underserved Population

PROJECT_TITLE: A Multilevel Intervention to Reduce Disparities in Obstructive Sleep Apnea and Related Cardiometabolic Outcomes


NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health

PI_NAMEs: SHIMBO, DAICHI  (contact)

PROJECT_TERMS: Acceleration;Address;biomedical informatics;Biomedical Research;Biometry;career;Chronic Disease;Cities;Clinical;Clinical and Translational Science Awards;Clinical Research;cohort;Collaborations;college;Communities;community based participatory research;community based research;community center;community collaboration;community organizations;Country;data harmonization;Development;disease disparity;Disease Outcome;disparity elimination;disparity reduction;Exposure to;Faculty;Foundations;Funding;Goals;Group Affiliation;Health;Health Disparities Research;health disparity;health equity;Health equity research;health inequalities;Health Services;health training;Healthcare Systems;higher education;Hospitals;implementation science;improved;Individual;innovation;Institution;Intervention;Knowledge;Lead;Localized Disease;Medical center;meetings;member;Mentors;Mission;multidisciplinary;New York;New York City;next generation;novel;Outcome;Physicians;Pilot Projects;Policies;Population;Presbyterian Church;Prevention;Principal Investigator;programs;Provider;Public Health;Public Health Schools;Reduce health disparities;Research;Research Methodology;Research Personnel;Resources;Scientist;skills;synergism;System;Training;Training and Education;Training Programs;Underrepresented Populations;United States National Institutes of Health;Universities;Woman;Work


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Automated liquid handling systems have transformed biomedical research laboratories by enabling scientists to conduct programmable reactions from low-volume samples. However, most existing systems suffer from drawbacks such as surface adsorption, cross contamination, and limited programmability. The objective of the proposed project is to develop an acoustic-based technology that overcomes these key obstacles and enables a highly programmable, biocompatible, and high-throughput fluidic processor.

PI_NAMEs: HUANG, TONY JUN  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Acoustics;Address;Adsorption;Area;Automation;Automobile Driving;Benchmarking;Biological Assay;biological systems;Biology;biomaterial compatibility;Biomedical Research;Bite;Blood;Cell Line;Cell Survival;chemical reaction;Chemistry;Clinical Chemistry;clinical diagnostics;comparative cost effectiveness;Complex;Crystallization;design;Development;Devices;Diffusion;digital;Drug Screening;electric field;Electronics;Face;high-throughput drug screening;improved;Industry Standard;interest;invention;Laboratories;Laboratory Research;Libraries;Liquid substance;Magnetism;Manuals;Medicine;Methods;Microfluidics;microsystems;Miniaturization;model organism;Monitor;Organic solvent product;Performance;Pharmacologic Substance;Preparation;pressure;Property;Proteins;prototype;Reaction;Reagent;Reproducibility;Research;Research Personnel;Risk;Robotics;Route;Sampling;Scientist;screening;Series;Solid;Speed;Sputum;stool sample;Structure;Surface;System;Technology;technology research and development;Time;tool;Transducers;United States National Institutes of Health;Universities;Viscosity;voltage

PROJECT_TITLE: Development of a digital acoustofluidic system for automating liquid handling in biomedical research

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Substance Misuse

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Black/African-Americans use alcohol and illicit drugs at the same rates as their white counterparts but are much more likely to suffer negative substance related consequences. Moreover, they are less likely to initiate treatment when compared with other racial groups; and when they do, are significantly less likely to complete treatment or to be offered evidence-based treatments. Offering validated, technology-based treatments in alternative settings, such as the Black Church, a highly trusted entity in Black communities, is a novel, and potentially highly disseminable strategy for improving access to evidenced-based treatments and improving alcohol treatment outcomes for this important population.

PI_NAMEs: JORDAN, AYANA  (contact)

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: addiction;Address;Adult;African American population;alcohol abuse therapy;Alcohol consumption;alcohol use disorder;Alcohols;Area;Black church;Black Populations;Black race;Caring;Characteristics;Church;Clinical Trials;Cognitive Therapy;Communities;comorbidity;Complex;Coping Skills;Diagnosis;drinking;E-learning;ethnic identity;Evaluation;Evidence based treatment;follow-up;Gender;health disparity;Health Services Accessibility;Healthcare;Heavy Drinking;Homelessness;Illicit Drugs;Improve Access;improved;Individual;interest;Intervention;Interview;Jordan;low socioeconomic status;marginalized population;Measures;Medical;medical specialties;Mental Health;Modeling;National Institute on Alcohol Abuse and Alcoholism;novel;Outcome;Outpatients;Participant;Pathway interactions;Population;primary outcome;Quality of life;racial population;Randomized;randomized, clinical trials;relative cost;Religiosity;Sampling;satisfaction;secondary outcome;Severities;Site;social health determinants;social stigma;Social support;standard care;substance use;Substance Use Disorder;System;Technology;Training;treatment comparison;treatment effect;Treatment outcome;Trust;Underserved Population

PROJECT_TITLE: Addressing health disparities by providing evidence-based treatment in the Black Church


NIH_SPENDING_CATS: American Indian or Alaska Native;Bioengineering;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Pulse oximetry has played a crucial role during the COVID-19 pandemic because measurements of hypoxemia serve as the major indication for hospitalizing patients, but clinical studies have shown that commercially available pulse oximeters can systematically overestimate true arterial oxygen saturation for persons with dark skin pigmentation. This bias has resulted in respiratory compromised persons with dark skin not meeting criteria for hospitalization or initiation of ventilator support, thereby putting specific populations (Black, Latinx, and Native American) at disproportionately greater risk for higher mortality or morbidity compared to those with light skin. In view of our pilot research showing that the bias is due, at least in part, to the devices’ use of polychromatic red light-emitting diode (LED) light sources, we are proposing to present, develop, test, and promote an improved and more-accurate light-based technology for the provision and marketing of simple, inexpensive, and bias-free pulse oximeters.

PI_NAMEs: FIGUEIRO, MARIANA GROSS;HOROWITZ, CAROL R;REA, MARK S (contact);RICHARDSON, LYNNE D.

PROGRAM_OFFICER_NAME: GILCHRIST, KRISTIN HEDGEPATH

PROJECT_TERMS: absorption;Advocate;Affect;Air;Black race;Blood;Breathing;Calibration;Catheters;clinical practice;Clinical Research;Clinics and Hospitals;cohort;Collaborations;Communities;cost;COVID-19 pandemic;COVID-19 patient;Darkness;Data;Development;Devices;Diagnosis;Diagnostic;Disparate;Disparity population;Education and Outreach;Emergency Department Physician;Fingers;Fostering;Foundations;Health care facility;health equity;Health equity research;high risk;Home;hospital care;Hospital Supply;Hospitalization;Hospitals;human subject;Hypoxemia;improved;Institution;Latinx;Licensing;Light;light emission;Literature;Manufacturer;Marketing;Measurement;Measures;Medical;Melanins;member;Methodology;Minority Groups;Modeling;Monitor;Morbidity - disease rate;mortality;Native American population;Native Americans;operation;Oxygen;Oxygen saturation measurement;pandemic disease;Patients;Persons;Photoplethysmography;Physicians;Physiologic pulse;Pilot Projects;Play;Policies;Population;Population Heterogeneity;preference;Printing;prototype;Provider;Publishing;Pulse Oximetry;Radial;Research;respiratory;Risk;Role;sensor;Skin;Skin Pigmentation;social media;Source;Specific qualifier value;Systematic Bias;Technology;Testing;Therapeutic;tool;Translating;transmission process;Underrepresented Minority;Ventilator

PROJECT_TITLE: Supporting health equity with bias-free pulse oximetry


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Obesity;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

PHR: NARRATIVE: Sleep health disparities contribute to the disproportionate burden of poor cardiometabolic health in Latinx, and its downstream effects on risk for multiple chronic diseases. The DREAM randomized controlled trial will evaluate the effect of a community health worker-delivered multidimensional sleep health intervention on multiple domains of cardiometabolic health in middle-aged to older Latinx men and women. Culturally adapted sleep health interventions may elucidate scalable and sustainable contextual behavioral approaches to improve cardiometabolic health and extend healthspan.

PI_NAMEs: MAKAREM, NOUR  (contact)

PROJECT_TERMS: 2 arm randomized control trial;actigraphy;Address;Adult;Affect;aged;alertness;arm;behavior change;Behavior Therapy;Behavioral;behavioral sleep intervention;Biological;Biological Markers;Black Populations;Blood Pressure;Cancer Hospital;cancer prevention;cancer risk;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;Caribbean region;Cause of Death;Characteristics;Chronic Disease;Communities;community center;community engagement;Community Health Aides;Consolidated Framework for Implementation Research;culturally appropriate intervention;Development;Diet;Dimensions;Disease Outcome;Disparity;Education;Educational Materials;Effectiveness;Enrollment;Ensure;Equity;ethnic disparity;ethnic minority;Ethnic Origin;Evaluation;evidence base;experience;Feedback;Future;glycemic control;Goals;Health;health disparity;health equity;health training;healthspan;Height;High Prevalence;High Risk Woman;Hypertension;implementation determinants;implementation intervention;implementation science;improved;Individual;inflammatory marker;Intervention;intervention effect;Language;Latinx;Life;lifestyle factors;lifestyle intervention;Malignant Neoplasms;Measures;men;Methods;middle age;minority health;Modeling;Monitor;Morbidity - disease rate;mortality;Motivation;multiple chronic conditions;National Institute on Minority Health and Health Disparities;New York;New York City;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;Obesity;Outcome;Pathway interactions;Physical activity;poor sleep;population health;Presbyterian Church;primary outcome;Process;Public Health;racial disparity;racial minority;Randomized;Randomized, Controlled Trials;Reduce health disparities;Research;Risk;Risk Factors;Role;satisfaction;scale up;Screening for cancer;secondary outcome;Sleep;sleep health;sleep quality;Spanish;systematic review;systemic inflammatory response;Techniques;Testing;Time;treatment arm;trial design;Washington;Woman;Work

PROJECT_TITLE: Project 1: Addressing Sleep Duration, Regularity, and Efficiency: A Multidimensional Sleep Health Intervention for Reducing Ethnic Disparities in Cardiometabolic Health (The DREAM Study)


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Organ Transplantation;Regenerative Medicine;Transplantation

ORG_CITY: PITTSBURGH

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE A deeper understanding of the mechanisms by which transplants communicate with the recipient’s immune cells is required for development of better therapies to prevent or treat rejection of transplanted tissues and organs, including cardiac allografts. Recent studies have shown that allografts release donor antigens and likely immune-stimulatory signals through small extracellular vesicles that travel to graft-draining lymphoid tissues, where the vesicles elicit the anti-donor immune response that causes transplant rejection. Our application proposes to unveil in mouse transplantation models and a in a clinical translational model of humanized mice, how graft extracellular vesicles communicate with the recipient’s immune cells in lymphoid tissues, which will provide answers to old questions in the field of transplantation and new grounds for development of novel therapeutic approaches against transplant rejection.

PI_NAMEs: MORELLI, ADRIAN E. (contact)

PROGRAM_OFFICER_NAME: KULKARNI, SHILPA S

PROJECT_TERMS: adaptive immune response;Adult;Affect;Allogenic;allograft rejection;Allografting;Antigen-Presenting Cells;Antigens;Apoptotic;B-Lymphocytes;Biogenesis;bioimaging;Biological Markers;Biology;Blood group antigen S;Cardiac;Caring;Cells;Childhood;Chronic;clinical translation;clinically relevant;Communication;conditioning;Development;Disease;Disease Marker;Distant;Electron Microscopy;exosome;Experimental Models;extracellular vesicles;Family;Future;Generations;Genetically Engineered Mouse;Goals;Graft Rejection;Heart;heart allograft;Heart failure;Heart Transplantation;horizontal cell;Human;humanized mouse;Immune;Immune response;Immune system;Immunity;immunoreaction;immunoregulation;Immunosuppression;Immunosuppressive Agents;improved;In Situ;in vivo;infection risk;Innate Immune Response;Intervention;Investigation;Investments;isoimmunity;Knowledge;Leukocytes;Lipids;Lung;Lymphoid Tissue;Malignant Neoplasms;Mediating;Mediator;Medical;Messenger RNA;Methodology;MHC antigen;microvesicles;mouse model;Mus;novel;novel therapeutic intervention;Organ;Patients;Peptides;prevent;promoter;Proteins;Regimen;Resolution;response;Risk;Role;Secondary to;side effect;Signal Transduction;Skin;skin allograft;Skin Transplantation;Structure of germinal center of lymph node;T memory cell;T-Lymphocyte;Testing;Therapeutic immunosuppression;Tissue Grafts;Tissue Transplantation;translational model;transplant model;Transplantation;Travel;two photon microscopy;ultra high resolution;Untranslated RNA;Vascularization;Vesicle;vesicular release

PROJECT_TITLE: Graft extracellular vesicles as promoters of anti-donor immunity in cardiac and skin transplantation

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Gene Therapy;Genetics;Human Genome;Immunotherapy;Orphan Drug;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Chimeric antigen receptor (CAR) T cells have been a breakthrough in personalized cancer treatment; however, this therapy is not effective for many patients. Preliminary findings suggest that the epigenetic modifier TET2 is involved in controlling T cell fate and function; thus, I propose to investigate TET2 to identify strategies to improve CART cell efficacy in response to tumor challenge. By investigating the mechanisms and extent to which TET2 modulates antitumor T cell function, this research has the potential to improve patient responses to CAR T cell therapy as well as illuminate more general mechanisms by which DNA modifying enzymes alter the epigenetic landscape to regulate gene expression.

PI_NAMEs: HOPKINS, CAITLIN ROSEMARY (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Antigens;ATAC-seq;Autologous;B lymphoid malignancy;B-Cell Acute Lymphoblastic Leukemia;base;Base Excision Repairs;Biological;Biological Assay;cancer cell;Cancer Patient;CAR T cell therapy;CD19 gene;CD8-Positive T-Lymphocytes;Cell Differentiation process;Cell Extracts;Cell Physiology;Cell Therapy;cell type;Cells;Cellular immunotherapy;chemotherapy;chimeric antigen receptor;chimeric antigen receptor T cells;ChIP-seq;Chromatin;chromatin remodeling;Chromatin Structure;Clonal Expansion;cytotoxicity;demethylation;Dioxygenases;Disease;DNA;DNA biosynthesis;DNA Methylation;DNA methylation profiling;DNA Modification Process;DNA Sequence Alteration;engineered T cells;Enzymes;Epigenetic Process;epigenetic regulation;Excision;exhaustion;Exhibits;Functional disorder;Gene Expression;Genes;Genetic Transcription;Genome;Health;histone modification;Histones;Human;Immune;improved;improved outcome;In complete remission;In Vitro;in vitro Assay;in vivo;Individual;Knock-out;Laboratories;leukemia;Link;Longevity;Malignant Neoplasms;Maps;Measures;Mediating;Memory;methylome;mouse model;mutant;Nature;Outcome;oxidation;Pathway interactions;patient response;Patients;personalized cancer therapy;Phenotype;Play;Post-Translational Protein Processing;Proliferating;Property;Proteins;receptor;refractory cancer;Regulation;Relapse;Research;Resolution;response;restraint;Role;Scientific Advances and Accomplishments;senescence;Shapes;Site;stem cells;success;T cell differentiation;T memory cell;T-Cell Proliferation;T-Lymphocyte;transcriptome;transcriptome sequencing;Treatment Failure;tumor;Tumor Immunity;Tumor-infiltrating immune cells

PROJECT_TITLE: Mechanisms of TET2-dependent control of CAR T cell fate determination and antitumor function


NIH_SPENDING_CATS: Bioengineering;Clinical Research

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE We propose to develop new soft, tip-extending robotic catheters with shape control that have the potential to increase access to endovascular procedures by enabling navigation of vessels that can currently only be performed by a small number of specialists. Our approach represents a fundamentally di↵erent method of movement through the vasculature compared to typical manual and robotic methods that rely on axial loading of semi-rigid catheters, and our approach has the potential to improve safety and e↵ectiveness of endovascular surgical procedures. The proposed research is relevant to public health because it seeks to improve outcomes and ultimately increase access to high-quality minimally invasive surgical procedures.

PI_NAMEs: MORIMOTO, TANIA KIYOYE (contact)

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: Acute;Address;Anatomy;Aneurysm;Animal Model;arm;Arteries;Autopsy;base;Behavior;Blood coagulation;Blood Substitutes;Blood Vessels;Brain Diseases;Caring;Catheterization;Catheters;Clinical;Complex;Coronary Arteriosclerosis;Data;Death Rate;design;Disease;Distal;Endothelium;Environment;Equipment;Exhibits;Face;Family suidae;Goals;Growth;Heart Diseases;high risk;Histologic;improved;improved outcome;in vivo;Inguinal region;Injury;innovation;instrument;Liquid substance;Liver diseases;Location;Manuals;Methods;minimally invasive;Minimally Invasive Surgical Procedures;Modeling;Movement;older patient;operation;Operative Surgical Procedures;Outcome;Patient imaging;Patients;Plants;pressure;Procedures;Public Health;Recovery;renal artery;Research;robotic system;Robotics;Rotation;Safety;Shapes;Side;Silicones;Specialist;Stroke;Structure;success;Surgeon;System;Techniques;Tendon structure;Testing;Thrombectomy;Time;tool;Training;Travel;Vascular Diseases;vascular injury;Work;X-Ray Computed Tomography

PROJECT_TITLE: VINE Catheter: Soft, Tip-extending, Robotic Catheters with Shape Control for Endovascular Surgery

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: PORTLAND

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Narrative People with type 1 diabetes have difficulty managing their glucose levels, especially during the daytime in response to carbohydrate intake; persistently elevated glucose levels can lead to dangerous, poor overall health outcomes including retinopathy, neuropathy, and nephropathy. We will develop a new dual hormone (insulin and pramlintide), fully automated closed loop system that can automatically detect meals and dose in response to these meals. By combining the slowed gastric emptying and suppression of endogenous glucose production that pramlintide provides with a meal detection algorithm, we expect to translate a fully automated closed loop system with minimal patient burden that can achieve substantial improvements in glycemic control both during the evening and during the day.

PI_NAMEs: JACOBS, PETER G (contact);WILSON, LEAH MEGAN

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Adult;Algorithms;analog;Area;Area Under Curve;arm;Artificial Intelligence;autoimmune pathogenesis;Automobile Driving;Beta Cell;blood glucose regulation;carbohydrate metabolism;Carbohydrates;Clinic;Clinical;clinical efficacy;Clinical Research;Clinical Trials;Consumption;Continuous Glucose Monitor;Continuous Infusion;Cross-Over Studies;Dangerousness;design;Detection;diabetes control;Dose;Engineering;Evaluation;Exercise;FDA approved;forgetting;Gastric Emptying;Gastroparesis;Glucagon;Glucose;glucose metabolism;glucose production;glycemic control;Goals;Health;Hormones;Hour;Hybrids;Hypoglycemia;improved;in silico;Injections;Inpatients;Insulin;Insulin Infusion Systems;Insulin, Aspart, Human;Insulin-Dependent Diabetes Mellitus;Intake;islet amyloid polypeptide;Kidney Diseases;Kinetics;Metabolic;Metabolism;Modality;Modeling;Nausea;Neuropathy;Outcome;Outcome Measure;Outpatients;Participant;patient population;Patients;Pattern;Persons;pharmacokinetics and pharmacodynamics;Population;Pramlintide;predictive modeling;primary outcome;Production;Publishing;Pump;Randomized;recruit;response;Retinal Diseases;safety and feasibility;sensor;simulation;subcutaneous;System;Testing;Time;Translating;virtual patient;wireless;Work

PROJECT_TITLE: Enabling Fully Automated Closed Loop Control in Type 1 Diabetes Through an Artificial Intelligence Meal Detection Algorithm and Pramlintide

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ADMINISTERING_IC: FD

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative: The University of Kentucky Division of Regulatory Services (UKDRS) achieved full implementation and conformance to the Animal Feed Regulatory Program Standards (AFRPS) in August of 2019. Moving forward, UKDRS requests continued funding support to continue full conformance with the AFRPS, to maintain an integrated animal feed safety system, and to advance the cooperative agreement with FDA. It is the goal of the UKDRS to be an effective component of an integrated animal feed safety system within the United States. Multiple activities will be supported through this project including continued funding for our AFRPS Coordinator, training, travel, feed sampling activity, conducting complaint investigations, and conducting animal feed manufacturer inspections.

PI_NAMEs: HARRISON, GLEN ALAN (contact)

PROGRAM_OFFICER_NAME: BHATTACHARYYA, SOMA

PROJECT_TITLE: The University of Kentucky Division of Regulatory Services (UKDRS) continued development of a risk-based Animal Feed Inspection Program


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Breast Cancer;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PHR: RELEVANCE There are long-standing disparities in adherence to medications and health outcomes in patients with multiple chronic conditions. This project will apply a “design with justice” process to refine a multicomponent adherence intervention targeting combined adherence to medications prescribed for breast cancer and cardiovascular disease. If successful, we will have developed an adherence intervention that can be adapted to improve adherence to other chronic conditions in a scalable and equitable manner.

PI_NAMEs: HERSHMAN, DAWN  (contact)

PROJECT_TERMS: Address;Adherence;Adult;Anti-Hypertensive Agents;Attention;Behavior;behavior change wheel;Black race;black women;Blood Pressure;Breast Cancer survivor;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular effects;Caring;Cause of Death;Cellular Phone;Chemosensitization;Chronic;Chronic Disease;Clinic;Clinical;cohort;Combination Medication;Communities;community center;Community Health Aides;Community Healthcare;community partners;comorbidity;Complex;Consolidated Framework for Implementation Research;contextual factors;cost;Death Rate;design;Disease Outcome;Disparity;disparity reduction;Dose;Drug Prescriptions;effective intervention;effectiveness evaluation;Effectiveness of Interventions;effectiveness testing;effectiveness/implementation design;Equity;Ethnic Origin;Event;Feedback;Focus Groups;Frequencies;Health;health care disparity;health disparity;health equity;Health Personnel;Health system;health training;Heart Diseases;High Prevalence;high risk;Hispanic;hormone therapy;Hormones;Hospitalization;human centered design;Hybrids;implementation facilitators;implementation science;improved;improved outcome;Income;informant;innovation;Intervention;intervention refinement;Interview;Justice;Latina;LDL Cholesterol Lipoproteins;long-standing disparities;Low Income Population;Low-Density Lipoproteins;Malignant Breast Neoplasm;Malignant Neoplasms;Medical;medication compliance;medication nonadherence;Methods;Minority;Minority Groups;minority patient;modifiable risk;Monitor;mortality;mortality risk;motivational enhancement therapy;multi-component intervention;multiple chronic conditions;novel;Outcome;Patient Noncompliance;patient portal;Patients;Pharmaceutical Preparations;Pharmacists;Pharmacy facility;Policies;poor health outcome;Poverty;pragmatic trial;primary outcome;Process;Provider;Race;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;Reduce health disparities;Regimen;Research;Risk Factors;satisfaction;Self Efficacy;social health determinants;Social support;structural determinants;Surveys;Testing;theories;therapy design;Training;treatment as usual;Underrepresented Minority;White Women;Woman


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative    This proposal will expand access to cell immunotherapies for more people. We will build programmable iPSC-  derived  Dendritic  cells  as  a  way  to  identify  new  T  cell  receptor  immunotherapies  for  cancers  and  infectious   disease. These Dendritic Cells will be "off- the- shelf", HLA- customized, and loaded with potential universal cancer  targets.

PI_NAMEs: TRUONG, DAVID MINH (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Address;Adoptive Immunotherapy;Alleles;Allogenic;Antigen-Presenting Cells;Antigens;Autologous Tumor-Infiltrating Lymphocyte;Award;Base Pairing;Basic Science;Binding;cancer immunotherapy;career;Cell Line;Cell Physiology;Cells;chemotherapy;chimeric antigen receptor;Clinic;combinatorial;Communicable Diseases;Complex;Consumption;Cytotoxic T-Lymphocytes;Dendritic Cell Vaccine;Dendritic Cells;differentiation in vitro;directed differentiation;DNA;efficacy testing;Endogenous Retroviruses;engineered T cells;Engineering;Epigenetic Process;Genes;Genetic;Genome;genome-wide;Goals;Haplotypes;Harvest;high reward;high risk;Human;Human Genome;human induced pluripotent stem cells;Immune;Immune system;Immunotherapy;In Vitro;induced pluripotent stem cell;induced pluripotent stem cell technology;Industrialization;invention;investigator training;Investments;Libraries;Malignant Neoplasms;manufacture;Mature T-Lymphocyte;Methods;Modification;monocyte;National Institute of Allergy and Infectious Disease;neoplastic cell;new technology;next generation sequencing;novel therapeutics;Patients;Peptides;peripheral blood;Persons;Population;Positioning Attribute;Postdoctoral Fellow;Procedures;programs;Proliferating;receptor;refractory cancer;Reporter;Research;Research Personnel;Role;Safety;Solid Neoplasm;Source;Stress;Stretching;Surface;synthetic biology;System;T-Cell Activation;T-Cell Receptor;T-Cell Receptor Therapy;T-Lymphocyte;Technology;technology development;technology platform;Testing;Therapeutic;Time;Training;Transfection;Transgenes;tumor;Tumor Antigens;Tumor-Infiltrating Lymphocytes;Untranslated RNA;Vaccines;Validation;Vision;Work;Writing

PROJECT_TITLE: Programmable Off-the-Shelf Dendritic Cells as an Immunotherapy Discovery Platform


ORG_CITY: INDIANAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Overall Narrative Worldwide, cervical cancer remains one of the most common malignancies in women, particularly in those who are HIV-infected. The core objective of this application is to better elucidate the natural history of human papillomavirus infection and the development of cervical cancer in HIV-infected women. These include to clarify the cofactors involved in carcinogenesis, the persistence and progression of cervical intraepithelial neoplasia (CIN) after local therapies, and to identify new viral and cellular biomarkers that will ultimately assist in screening, triage and treatment.

PI_NAMEs: BROWN, DARRON R;ITSURA, PETER ;LOEHRER, PATRICK J. (contact);NAKALEMBE, MIRIAM

PROGRAM_OFFICER_NAME: DOMINGUEZ, GERALDINA

PROJECT_TERMS: Acetic Acids;Aflatoxins;Africa;Africa South of the Sahara;African;African Women;AIDS related cancer;antiretroviral therapy;Biological;Biological Factors;Biological Markers;Biometry;carcinogenesis;career;Cervical;Cervical Cancer Screening;cervical carcinogenesis;Cervical dysplasia;Cervical Intraepithelial Neoplasia;Cervix Neoplasms;Clinical;cofactor;Communicable Diseases;Data;data management;Dedications;design;Development;Diagnosis;DNA;Environmental Risk Factor;Epidemiology;Goals;HIV;HIV/AIDS;HPV-High Risk;Human papilloma virus infection;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Incidence;Ingestion;international partnership;Kenya;Knowledge;Lesion;Local Therapy;loop electrosurgical excision procedure;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mentors;Natural History;Nurses;Outcome;Physicians;Pilot Projects;premalignant;Prevalence;prevent;programs;Research;Research Infrastructure;Research Personnel;Resource Sharing;Scientist;screening;Testing;Training;Training Programs;Translational Research;Triage;Uganda;Viral;Visual;Woman

PROJECT_TITLE: The East Africa Consortium for HPV and Cervical Cancer in Women living with HIV/AIDS


NIH_SPENDING_CATS: Cancer;Cervical Cancer;HIV/AIDS;Infectious Diseases;Rare Diseases;Sexually Transmitted Infections;Women's Health Research

PHR: Narrative The overall goal of the Administrative and Coordination Core is to oversee the administration of the East Africa Consortium for HPV and Cervical Cancer (EACHC) in Women Living with HIV/AIDS. The A&C Core also coordinates the activities of all investigators involved on three projects and the three additional cores, and to facilitate communication within and between the North American, Ugandan and Kenyan institutions and other organizations in which the EACHC will directly interact.

PI_NAMEs: LOEHRER, PATRICK J. (contact)

PROJECT_TERMS: adjudication;Advisory Committees;Africa;AIDS related cancer;American;Biology;Biometry;Collaborations;Communication;Communities;community engagement;Community Outreach;Country;Data;data management;Development;Goals;HIV/AIDS;Human Papilloma Virus-Related Malignant Neoplasm;Information Dissemination;Institution;inter-institutional;Malignant neoplasm of cervix uteri;member;Morbidity - disease rate;mortality;North America;Participant;Pilot Projects;Research;Research Infrastructure;Research Personnel;Services;Woman

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Comparative Effectiveness Research;Digestive Diseases;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Nutrition;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: NARRATIVE The CHURCH Trial aims to reduce disparities in Colorectal Cancer (CRC) screening and cardiovascular disease (CVD) risk factors linked to increased risk of CRC. This cluster randomized controlled trial (RCT) will employ Community Health Workers (CHWs) in a cohort of 22 African American churches in New York City. We will assess CRC screening uptake (Primary Outcome) and dietary inflammation score (DIS) and Life Simple-7 scores (Secondary Outcomes) at 6- and 12-months post-intervention and conduct a mixed-methods process evaluation to assess multi-level facilitators and barriers of screening uptake.

PI_NAMEs: WILLIAMS, OLAJIDE  (contact)

PROJECT_TERMS: Address;Adult;African American;African American population;Anxiety;arm;Barbering;barrier to care;Black church;brief intervention;cancer prevention;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;care seeking;Certification;Chronic Disease;Church;cohort;Colonoscopy;Colorectal;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;colorectal cancer screening;Communities;community academic partnership;Community based prevention;community center;community engaged research;Community Health Aides;Complex;Conscious;Consolidated Framework for Implementation Research;contextual factors;Contracts;Death Rate;Diet;dietary;Disease Outcome;disorder prevention;Disparity;disparity reduction;DNA;Education;Effectiveness;effectiveness/implementation design;Enrollment;evidence base;Evidence based intervention;Excision;experience;Fright;Funding;Future;Goals;Guidelines;health care service;health equity;Health Insurance;Health Promotion;health record;Health Services Accessibility;Health system;health training;high risk;high risk population;Hispanic;Hybrids;improved;Incidence;Inequity;Inflammation;Inflammatory;Influentials;Institution;instrument;Intervention;intervention delivery;intervention effect;Intervention Studies;Knowledge;Life;Life Style;Link;literacy;Malignant Neoplasms;men;Mental Depression;Methods;Modeling;mortality;motivational enhancement therapy;New York City;NIH Program Announcements;novel;Online Systems;Participant;patient navigation;peer;Persons;post intervention;premalignant;Premature Mortality;primary outcome;process evaluation;programs;Protocols documentation;racial population;racism;Randomized;randomized trial;Randomized, Controlled Trials;recruit;Research;response;Risk Behaviors;Risk Factors;scale up;screening;Screening for cancer;screening, brief intervention, referral, and treatment;secondary outcome;Social Environment;social health determinants;Stroke;Structural Racism;Training;treatment arm;treatment as usual;Trust;United States National Institutes of Health;uptake;Work

PROJECT_TITLE: Project 3-Community Health workers United to Reduce Colorectal cancer and CVD among people at Higher risk (CHURCH)


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Cervical Cancer;Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Prevention;Rare Diseases;Sexually Transmitted Infections;Women's Health Research

PHR: Narrative Our objective in the translational biology core (TBC) is to support the three projects in this proposal, enhance the research capabilities in Kenya and Uganda, and to foster young African investigators as they begin their careers in science and the study of HIV-associated cancers.

PI_NAMEs: ERMEL, AARON  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Africa;Africa South of the Sahara;African;African Women;Age;AIDS related cancer;American;antiretroviral therapy;Area;Behavioral;biobank;Biological;Biology;Biometry;Cancer Burden;cancer care;career;Caring;CD4 Lymphocyte Count;Cessation of life;chronic infection;Clinical;Collaborations;Consent;Country;Data;data management;data sharing networks;Databases;Developed Countries;Development;Diagnosis;Disease;Disparity;Environment;Environmental Risk Factor;epidemiologic data;Epidemiology;Fostering;Funding;genome sequencing;Goals;Healthcare;HIV;HIV Infections;HIV/AIDS;Home;HPV-High Risk;Human;Human papilloma virus infection;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16;immune reconstitution;Immunohistochemistry;improved;improved outcome;Incidence;Infection;Infrastructure;Institution;International;Investigation;Kenya;Knowledge;Laboratories;Lesion;Link;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;member;Molecular;next generation sequencing;Oncogenic;Oncology;Outcomes Research;Participant;pathogen;Pathology;Patients;Pilot Projects;Population;population health;premalignant;Prevalence;Prevention;Prevention program;Process;programs;prospective;Research;Research Personnel;Resources;Risk;Role;routine screening;Sampling;Science;Scientist;screening;screening program;Secure;Services;Site;skills;Specimen;Techniques;Technology;Testing;Tissues;Total Quality Management;Training;treatment program;Uganda;Universities;Viral;whole genome;Woman;Women's prevalence;Women's study;Work

PROJECT_TITLE: Translational Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Sleep Research

PHR: PROJECT NARRATIVE  The goal of this program is to train graduate students, physician-scientists and postdoctoral nursing fellows to conduct research in sleep and circadian disorders.

PI_NAMEs: PACK, ALLAN I (contact);RAIZEN, DAVID MENASSAH;RIEGEL, BARBARA J;SAWYER, AMY M;SEHGAL, AMITA

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: Sleep;Sleep Disorders;Training

PROJECT_TITLE: Training in Sleep & Sleep Disorders

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


PHR: Narrative The Biostatistics and Data Management Core (BDMC) will leverage decades-long experience with collecting, harmonizing, validating, combining and analyzing data from multiple countries, programs hardware and software platforms in East Africa, and longstanding collaborations with investigators and institutions in the region, through the East Africa Regional Consortium of the International Epidemiology Databases to Evaluate AIDS (IeDEA-EA).

PI_NAMEs: YIANNOUTSOS, CONSTANTIN THEODORE (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;advanced analytics;Africa;analytical method;archive data;Archives;Biometry;career development;Cervical;Collaborations;Collection;Computer software;Country;Data;Data Analyses;data centers;Data Collection;data exchange;data literacy;data management;data quality;Databases;Derivation procedure;design;Development;Ensure;Epidemiology;Exercise;experience;experimental study;Grant;Health;HIV/AIDS;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human Resources;human subject protection;Informatics;Institution;instrument;International;Lead;Leadership;Link;Malignant neoplasm of cervix uteri;Manuscripts;member;Mentorship;Methods;Pilot Projects;Privatization;Procedures;programs;Reporting;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;research study;Resource Sharing;Sample Size;Secure;Site;Statistical Data Interpretation;statistics;symposium;Training;Training Activity;Training and Education;training opportunity;transmission process;Validation;Woman;Work;Writing

PROJECT_TITLE: Biostatistics and Data Management Core


PHR: Narrative The overall goal of the Developmental Core is to enhance the research training, leadership capacity and professional networking for junior Kenyan and Ugandan health care professionals who are interested in addressing research questions related to HIV-associated malignancies. This U54 renewal application continues to focus on strengthening research capacity related to human papillomavirus (HPV) and cervical cancer in HIV- infected women of East Africa.

PI_NAMEs: ROSEN, BARRY  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Advisory Committees;Africa;AIDS related cancer;American;Applications Grants;Award;Budgets;career development;Career Mobility;career networking;Chronic Disease;cohort;Collaborations;Country;Data;Databases;Development;Educational process of instructing;Epidemiology;Evaluation;Faculty;Fellowship;Fostering;Future;global health;Goals;Grant;Group Meetings;health care availability;Health Professional;HIV;HIV/AIDS;Hospital Referrals;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;improved;Informed Consent;interest;International;Journals;Kenya;Leadership;leadership development;Long-Term Care;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Manuscripts;medical schools;meetings;member;Mentors;Mentorship;Modeling;next generation;North America;Nurses;Occupational activity of managing finances;Participant;Peer Review;Physicians;Pilot Projects;population based;Principal Investigator;Process;Productivity;Prognosis;Program Development;programs;Publications;Research;Research Methodology;Research Peer Review;Research Personnel;Research Project Grants;Research Proposals;Research Training;Resources;Role;Scientist;Site;skills;Social Workers;study population;success;Sustainable Development;symposium;Technical Expertise;tool development;Training;Training Activity;Training Programs;Travel;Uganda;Universities;Videoconferencing;Woman;Writing

PROJECT_TITLE: Development Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative The project presents a new approach to studying mammalian brain development. The proposal is to apply modern molecular tools and new behavioural assays in a mouse-sized marsupial that is born at stage 18 (equivalent to human seven-week gestation) and develops further in their mother's pouch. Longitudinal studies in this model will provide unprecedented access to study the functional and behavioural outcomes of fetal disruptions to circuitry and could be applied to test therapeutic interventions.

PI_NAMEs: RICHARDS, LINDA J (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Address;Adult;Affect;Animals;Area;awake;Behavior;Behavioral;Behavioral Assay;behavioral outcome;Birth;Brain;Calcium;calcium indicator;cell type;Cells;Cerebral cortex;Complex;Development;Electroporation;Embryo;Ensure;experience;experimental study;Fatty acid glycerol esters;fetal;Fire - disasters;functional outcomes;Human;Image;imaging capabilities;in vivo;Knowledge;Learning;Life;life span;Link;Longitudinal Studies;Mammals;Marsupialia;Mediating;Modeling;Modernization;Molecular;Mothers;Mus;neural;neural circuit;Neurons;novel strategies;Pattern;Phase;Pregnancy;Process;Psyche structure;pup;Reaction;Research;Rodent;Sensory;serial imaging;Shapes;System;Tail;Technology;therapeutic evaluation;Therapeutic Intervention;tool;Travel;Visual System;Work

PROJECT_TITLE: Emergence of activity patterns in the cerebral cortex and their influence on brain circuit development and function


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: SAN DIEGO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Because preschool-age irritability that persists into school-age predicts lifespan mental disorder and poorer functional outcomes, identifying the neural mechanisms by which children persist vs. remit in irritability is paramount to intervene in the earliest phase of the clinical cascade. Our overall goal is to identify reward- and inhibition-related neural pathways that characterize persistence vs. remission of early childhood irritability and may be targets for future novel preventive efforts. Our project is significant because it will pave the way for precision medicine for irritability: providing the right treatment (based on neural mechanisms) to the right people (children who will persist in irritability), at the right time (preschool age, before irritability problems worsen).

PI_NAMEs: DOUGHERTY, LEA R;WIGGINS, JILLIAN LEE (contact)

PROGRAM_OFFICER_NAME: PACHECO, JENNIFER LYNN

PROJECT_TERMS: 5 year old;6 year old;Accounting;Adult;Age;age related;Amygdaloid structure;Anger;Anxiety;Brain;brain behavior;Child;Child Rearing;Childhood;Chronic;Clinical;Cognition;contextual factors;Corpus striatum structure;Data;Development;Disease;Disease remission;early childhood;Early Diagnosis;Early identification;Early Intervention;economic outcome;Evaluation;experience;Feedback;financial incentive;first grade;follow-up;Friends;Frustration;Functional Magnetic Resonance Imaging;functional outcomes;Future;Goals;Image;Impairment;innovation;Internet;Interview;life span;Life Stress;Link;Machine Learning;machine learning method;Maintenance;Measures;Mental Depression;Mental disorders;Methods;middle childhood;neural;neural circuit;Neural Inhibition;neural network;Neural Pathways;neuroimaging;neuromechanism;Neurophysiology - biologic function;novel;Nursery Schools;Parents;Participant;Pattern;Persons;Phase;precision medicine;Prefrontal Cortex;prevent;Preventive;Psychopathology;recruit;Reporting;Research Domain Criteria;resilience;reward processing;Rewards;Risk;Risk Factors;Role;School-Age Population;Services;sex;Sex Ratio;socioeconomics;stressor;suicidal;support network;Symptoms;Temperament;Time;Variant;Work

PROJECT_TITLE: Neural mechanisms of risk and resilience in early childhood irritability

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;HIV/AIDS;Infectious Diseases;Prevention;Rare Diseases;Sexually Transmitted Infections;Women's Health Research

PHR: Narrative Our objective is to help eradicate cervical cancer in HIV-infected Kenyan/Ugandan women by 1) evaluating HPV DNA testing of self-collected vaginal swabs combined with VIA in screening, and 2) determine if aflatoxin is a risk factor for oncogenic HPV detection and cervical cancer.

PI_NAMEs: BROWN, DARRON R (contact)

PROJECT_TERMS: Acceleration;Acetic Acids;Aflatoxins;Africa;Africa South of the Sahara;AIDS related cancer;antiretroviral therapy;Biopsy;carcinogenicity;Caring;CD4 Lymphocyte Count;Cervical Cancer Screening;Cervical dysplasia;Cervical Intraepithelial Neoplasia;Clinical;cofactor;cost;Cost Effectiveness Analysis;Country;Data;Databases;design;Detection;DNA;experience;Exposure to;HIV;HIV/AIDS;HPV screening;HPV-High Risk;Human papilloma virus infection;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;immune reconstitution;Immune system;Immunosuppression;Immunosuppressive Agents;Impairment;improved;Incidence;Infrastructure;insight;Kenya;Literature;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Medical;Methods;Mycotoxins;Natural History;Oncogenic;Outcome;Plasma;Policies;Prevalence;prevent;programs;Research;Risk;Risk Factors;screening;Screening procedure;Swab;Testing;Training;Uganda;Vagina;Viral load measurement;Virus;Visual;Woman

PROJECT_TITLE: Project 1-Preventing cervical cancer in HIV-infected women


PHR: PROJECT NARRATIVE N6-methyladenosine (m6A) is the most abundant post-transcriptional modification of eukaryotic mRNAs. In vitro studies have demonstrated that m6A modification influences all fundamental aspects of mRNA metabolism, but its in vivo functions in mammalian physiology remain elusive. The role of m6A mRNA methylation in innate immunity, particularly in macrophage activation, is completely unknown. In this application we will investigate the mechanism whereby macrophage m6A mRNA methylation regulates innate immunity in the context of acute inflammatory stress (i.e. sepsis).

PI_NAMEs: LI, YAN CHUN  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Acute;Adenosine;Bacterial Infections;Binding;biological adaptation to stress;Biological Process;Biology;Cause of Death;cecal ligation puncture;chemokine;Clinical;cytokine;cytokine release syndrome;Data;Death Rate;Development;Feedback;genetic information;Genetic Transcription;Goals;Gram-Negative Bacterial Infections;Immune response;Impairment;In Vitro;in vitro Model;in vivo;Infection;Inflammatory;Intensive Care Units;Learning;Lipopolysaccharides;Macrophage;Macrophage Activation;Mediating;Memory;Messenger RNA;Metabolism;methyl group;Methylation;Methyltransferase;Modeling;Modification;Molecular;mortality;mRNA Stability;mRNA Transcript Degradation;mRNA Translation;Mus;Mutant Strains Mice;Myeloid Cells;Natural Immunity;NF-kappa B;Organ;Pathway interactions;Patients;Personal Satisfaction;Physiology;Play;posttranscriptional;Production;Proteins;Reader;Regulation;Resolution;response;Role;Sepsis;septic;Serum;Site;Stress;Suppressor of Cytokine Signaling Family Protein;Tissues;Transcript;Translations

PROJECT_TITLE: Roles of m6A mRNA Methylation in Innate Immunity

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;HIV/AIDS;Infectious Diseases;Rare Diseases;Sexually Transmitted Infections;Women's Health Research

PHR: Narrative HIV-infected women have a higher risk of persistent high-risk HPV infection leading to higher rates of cervical intraepithelial neoplasia (CIN) 2/3. The standard of care for CIN2/3 is loop electrosurgical excision procedure (LEEP). However, there is a gap in our understanding of recurrent CIN 2/3. This study proposes to increase our understanding of recurrent CIN2/3 in order to decide the best treatment for this recurrence.

PI_NAMEs: ORANGO, ELKANAH OMENGE (contact)

PROJECT_TERMS: Acetic Acids;Address;Adopted;Africa;Age Years;Appearance;Back;Biopsy;Cancer Etiology;cancer invasiveness;Cervical;Cervical Intraepithelial Neoplasia;Cervix Uteri;Characteristics;Cold Therapy;Colposcopy;Country;Development;Diagnosis;Disease;efficacy evaluation;Enrollment;Epidemiology;Excision;General Population;healing;High Prevalence;high risk;Histocompatibility Testing;HIV;HIV Seropositivity;HIV/AIDS;HPV-High Risk;Human papilloma virus infection;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16;Immune;Incidence;Intercellular Junctions;International Agency for Research on Cancer;Kenya;Lesion;loop electrosurgical excision procedure;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Natural History;novel strategies;Predisposition;prevent;Recommendation;Recurrence;Resources;Risk;Risk Factors;Science;screening;Specimen;standard of care;Tissues;Uganda;Visit;Visual;Woman;Women's mortality

PROJECT_TITLE: Project 2-Understanding CIN2+ among HIV infected women after LEEP: An epidemiological and immunohistochemical study


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Genetics;HIV/AIDS;Infectious Diseases;Prevention;Sexually Transmitted Infections;Women's Health Research

PHR: Narrative Recognizing that high-risk HPVs cause cervical cancer, and HIV can accelerate its development and progression, we will compare clinical screening examinations to collected biologic samples in order to quantify expression of functional biomarkers and identify HPV through typing and sequencing. These biomarkers represent the dysregulation human papillomavirus and HIV cause in their hosts; as such, by determining the expression and association of these biomarkers with clinical disease, and the virologic fingerprint of high-risk HPV found in Kenya and Uganda, we will create a roadmap to discriminate between women with greater risk for HPV-associated precancerous lesions, both with and without HIV co-infection.

PI_NAMEs: KATZENELLENBOGEN, RACHEL ADRIA (contact)

PROJECT_TERMS: Acceleration;Affect;Africa;Africa South of the Sahara;African;Antigen Presentation;antiretroviral therapy;Biological;Biological Markers;biomarker validation;Biopsy;Blood;cancer diagnosis;cancer risk;Cell Differentiation process;cell growth;Cells;cellular targeting;Cervical;Cervical dysplasia;Cervix Uteri;Clinical;clinical examination;clinical risk;co-infection;Collection;Country;CXCL1 gene;Data;Development;Diagnosis;Disease;DNA Tumor Viruses;Dysplasia;Environment;Epidemiology;epidemiology study;experimental study;Extracellular Matrix;Fingerprint;Fostering;Future;Gene Expression;Genetic;Genetic Polymorphism;genetic risk factor;Genetic Variation;genome sequencing;Goals;Healthcare;High Prevalence;high risk;High Risk Woman;HIV;HIV Infections;HIV Seropositivity;HIV/AIDS;HPV-High Risk;Human papilloma virus infection;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16;Immune response;Immunologic Adjuvants;Immunologic Surveillance;Immunomodulators;improved;Infection;Innate Immune System;insight;Investigation;Kenya;Knowledge;Lesion;Life Cycle Stages;Link;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Maps;Mediating;Modification;Morbidity - disease rate;mortality;Natural Immunity;Oncogenes;Pathology;Pathway interactions;peripheral blood;predictive marker;premalignant;Prevalence;Prevention;Preventive vaccine;prospective;Proteins;Research Personnel;Research Technics;Retroviridae;Risk;Risk Factors;risk stratification;RNA;Sampling;screening;Signal Transduction;skills;SLPI gene;specific biomarkers;Swab;synergism;Target Populations;TERT gene;timeline;Tissues;tumor microenvironment;tumor progression;Uganda;Variant;Viral;Viral Oncogene;virus genetics;virus host interaction;Visual;whole genome;Woman;Work

PROJECT_TITLE: Project 3-- Determining biological and viral factors associated with clinical progression of cervical dysplasia in HIV-infected women


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: College Station

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

ORG_STATE: TX

PHR: Narrative: Texas Animal Feed Regulatory Program Standards Maintenance and Preventive Controls Initiative During the next 5 years, OTSC will more fully integrate AFRPS through a number of activities including exploring how the preventive controls for animal food regulations could be incorporated into Texas Commercial Feed Rules, building a more robust facility risk ranking matrix and analysis platform, expanding audits to focus on PCAF and CGMP inspections, utilizing feed-related illnesses or death data in the risk ranking matrix, continue to evaluate industry compliance through the enforcement matrix, and incorporating Laboratory Flexible Funding Model program samples into the OTSC annual plan of work. OTSC will expand the number of qualified field investigators who can perform PCAF inspections by seven who will be supported by a Preventive Control Qualified Field Inspection Trainer and Auditor and offer new outreach programs.

PI_NAMEs: HERRMAN, TIMOTHY JOHN (contact)

PROGRAM_OFFICER_NAME: ISAKSON, ISAIAH


ORG_CITY: LAS CRUCES

ORG_NAME: NEW MEXICO STATE UNIVERSITY LAS CRUCES

ORG_STATE: NM

PHR: PROJECT NARRATIVE Funding provided through this Cooperative Agreement will allow the New Mexico Department of Agriculture to continue to develop and refine the Produce Safety program to reach the objectives of the FDA Produce Safety Rule. Such alignment necessitates a significant investment to successfully develop and implement a multi-faceted administrative program in support of the Produce Safety Rule. This grant opportunity provides New Mexico the resources necessary to advance efforts for a viable, aligned regulatory program contributing to a reduction of foodborne illness hazards and a nationally integrated food safety system.

PI_NAMEs: LANEY, KATIE  (contact)

PROGRAM_OFFICER_NAME: HOEHNA, SHANNON

PROJECT_TITLE: Path B Enhancement of NM Department of Agriculture's Produce Safety Program.


ORG_CITY: SALT LAKE CITY

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE Genetics is the study of how the information governing traits of an organism is decoded, how this information is stably passed on between generations, and how variant traits, including altered appearance, behaviors, birth defects, or disease states, arise. Studying the functions of genes, the control of their expression, and the effects of genetic variation give practical insights into how normal development and health are established and maintained, and how changes in gene function and expression contribute to congenital defects, aging, the origins of cancer, and the basis of many diseases. The goal of this Genetics Training Program is to give a diverse set of outstanding predoctoral researchers a broad education in genetics, intensive training in the process of performing and evaluating research in a rigorous and ethical manner, and mentorship and support of their development as productive members of society who apply their training in ethics, inclusiveness, and genetics during their careers.

PI_NAMEs: GOLIC, KENT G;GRUNWALD, DAVID J.;STANFIELD, GILLIAN  (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TITLE: University of Utah Genetics Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Services;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative This project will install lights along the bathroom or entry way doorframe of persons with Alzheimer's disease or related dementias who reside in assisted living, which are intended to promote postural stability and reduce nighttime falls. Given that a pilot study found a 34% reduction in falls due to the novel lighting intervention, this pragmatic passive lighting system has the potential to reduce falls and related sequelae for countless persons with Alzheimer's disease and related dementias, and to become a new standard of care.

PI_NAMEs: ZIMMERMAN, SHERYL  (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: Address;Adverse event;Alzheimer's disease related dementia;Ambulatory Care;Assisted Living Facilities;awake;Body Weight decreased;Cessation of life;Cognitive;community living;cost;Cross-Over Trials;Cues;Dangerousness;Dementia;dementia care;Development;effectiveness evaluation;effectiveness testing;Enrollment;Environment;Equilibrium;Event;experience;fall injury;fall risk;falls;Family;Family Caregiver;Floor;functional status;Hip Fractures;Hospitalization;human old age (65+);Impaired cognition;Impairment;Incidence;Individual;Injury;Intervention;intervention effect;Laboratories;light effects;Lighting;Modification;Monitor;Musculoskeletal Equilibrium;novel;Nursing Homes;older adult;Persons;Phototherapy;Pilot Projects;Posture;posture instability;Preventive;Privatization;Provider;Randomized;Recipe;Recording of previous events;Research;residence;Residential Treatment;Risk Factors;Sampling;satisfaction;sleep pattern;standard of care;System;Time;United States National Institutes of Health;Vision;Visual;Visual impairment;Work

PROJECT_TITLE: A Pragmatic Crossover Trial to Test the Effectiveness of a Novel Lighting System to Reduce Nighttime Falls in Persons with Alzheimer’s Disease and Related Dementias

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]