NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome;Prevention

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: PROJECT NARRATIVE Twenty to forty percent of cancer patients treated with chemotherapy develop oropharyngeal candidiasis (OPC), also known as thrush. Prevention of OPC during cancer treatment could lead to better compliance and quality of life, reductions in risk of systemic infection and decreased antifungal use. This proposal aims to identify the host and microbiome factors that contribute to OPC susceptibility in chemotherapy recipients and can serve as targets for preventive interventions.

PI_NAMEs: DIAZ, PATRICIA  (contact);SCHLECHT, NICOLAS

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Adhesions;Affect;Animal Model;anti-fungal agents;Area;Bacteria;bacteriome;Bioinformatics;Cancer Center;Cancer Patient;cancer therapy;Candida albicans;Characteristics;chemotherapy;Chemotherapy-Oncologic Procedure;Clinical;clinical application;Clinical Research;clinically relevant;Coculture Techniques;cohort;comorbidity;Data;Defect;Dental Plaque Index;design;Development;Dose;Epithelium;Etiology;experimental study;Filament;Functional disorder;Future;future implementation;Gene Expression;Genetic Transcription;Goals;Habits;Human;Immune;Immunologics;In Vitro;in vivo;Incidence;Individual;Infection;Infusion procedures;Intake;Invaded;Knowledge;Lactobacillus;Lead;Lesion;Leukopenia;longitudinal analysis;machine learning model;Measures;Mediating;Medical;Medical History;Mendelian disorder;microbial;microbiome;microbiome composition;Modeling;mouse model;Mucous Membrane;Multi-Drug Resistance;mycobiome;Neutropenia;neutrophil;Nutritional;Observational Study;Oral;oral bacteria;Oral candidiasis;oral microbiome;oral mucositis;Oral mucous membrane structure;oropharyngeal thrush;Pathogenicity;patient population;Patient Schedules;Patients;Peripheral;Pilot Projects;Play;Population;Porphyromonas;predictive modeling;Predisposing Factor;Predisposition;Prevention;Prevention strategy;Preventive;preventive intervention;Prevotella;Property;prospective;Quality of life;Research Infrastructure;Resistant candida;response;Risk;Risk Factors;Risk Marker;ROC Curve;Role;Salivary;Sampling;Severities;Smoking;Streptococcus;Systemic infection;Testing;Therapeutic Intervention;therapy development;Time;tool;Virulence;Virulence Factors;Xerostomia

PROJECT_TITLE: Host and microbial risk factors of oral thrush in cancer patients receiving chemotherapy

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: JACKSONVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: Amyotrophic lateral sclerosis (ALS) is an incurable disease of nerve cells that control muscles. Some patients with ALS have cognitive and behavioral abnormalities similar to frontotemporal dementia (FTD). Researchers in this program project aim to discover the cellular processes initiated by a mutation in the C9orf72 gene in order to improve the diagnosis of and prognosis for patients suffering from disorders collectively referred to as c9ALS/FTD.

PI_NAMEs: PETRUCELLI, LEONARD  (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Advisory Committees;Affect;Amyotrophic Lateral Sclerosis;amyotrophic lateral sclerosis therapy;Antisense Oligonucleotides;Area;Autopsy;Behavioral;Biochemical;Bioinformatics;Biological Markers;Biostatistics Core;Blood;Brain;brain tissue;C9ALS;C9FTD;c9FTD/ALS;C9ORF72;candidate marker;Cell Nucleus;Cell Physiology;cell type;Cells;Cellular Stress;Cerebrospinal Fluid;Clinical;Cognitive;Data;Data Analyses;Data Analytics;data integration;data sharing;data standards;Defect;design;Development;Diagnosis;Disease;disease model;Disease Pathway;Disease Progression;Early Diagnosis;Education;effective therapy;Ensure;Experimental Designs;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Funding;Gene Expression Profile;gene network;Genes;Genetic;Genetic Transcription;Goals;Histologic;Human;Impairment;improved;Individual;induced pluripotent stem cell;Interdisciplinary Study;Link;Mass Spectrum Analysis;Measurement;member;Methods;Molecular;Motor;Motor Cortex;mouse model;multidisciplinary;Multiomic Data;Mus;Muscle;Mutation;Nerve Degeneration;Neurology;neuron loss;Neurons;neuropathology;new therapeutic target;next generation;novel;Nuclear Pore Complex;nucleocytoplasmic transport;Pathway interactions;patient prognosis;Patients;potential biomarker;Productivity;Prognosis;Program Research Project Grants;programs;Progress Reports;Proteins;Proteome;Proteomics;recruit;Research;Research Personnel;Research Project Grants;Resources;response;responsible research conduct;sporadic amyotrophic lateral sclerosis;stress granule;Systems Biology;targeted biomarker;targeted treatment;Techniques;Testing;therapeutic biomarker;Therapeutic Intervention;therapeutic target;Tissues;transcriptome;transcriptome sequencing;transcriptomic profiling;transcriptomics;Translating;United States National Institutes of Health;Validation;Visualization;web portal;Work

PROJECT_TITLE: Pathobiology of Neurodegeneration in C9ORF72 repeat expansion


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Caregiving Research;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

PROJECT_TERMS: Accountability;Administrator;Advisory Committees;Amyotrophic Lateral Sclerosis;Animals;Awareness;Bioinformatics;Biological;Biological Markers;c9FTD/ALS;C9ORF72;Caregiver support;Charge;Clinic;Clinical Research;Collaborations;Critiques;Data;Data Analyses;data sharing;Department chair;Diagnosis;Disease;disease model;Doctor of Philosophy;Education;Enrollment;Ensure;Ethics;Event;Experimental Designs;Fostering;Foundations;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Funding;Genomics;Goals;Human Resources;human subject;Human Subject Research;improved;Individual;induced pluripotent stem cell;Interdisciplinary Study;Manuscripts;meetings;Modeling;Monitor;multidisciplinary;Muscular Dystrophies;National Institute of Neurological Disorders and Stroke;Nature;Nerve Degeneration;Nervous System Disorder;Neurology;neuropathology;Neurosciences;new therapeutic target;Pathologic;patient prognosis;Patients;Policies;Positioning Attribute;Productivity;Program Research Project Grants;programs;Progress Reports;Proteomics;Recommendation;Reporting;Research;Research Personnel;Research Project Grants;Research Proposals;Resources;responsible research conduct;Safety;Sampling;Scientist;Series;Structure;success;Support Groups;therapeutic biomarker;transcriptomics;United States National Institutes of Health;Work

PROJECT_TITLE: Admin Core


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetic Testing;Genetics;Human Genome;Precision Medicine;Prevention;Radiation Oncology;Rare Diseases

ORG_CITY: Loma Linda

ORG_DEPT: DENTISTRY

ORG_NAME: LOMA LINDA UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE  Oral squamous cell carcinoma (OSCC) survival has not significantly improved, and remains as low as 60% even amongst early stage OSCC patients. There is currently no reliable clinical, histologic or molecular marker to determine individual risk in patients within the same cancer stage. This study validates a risk score (the REASON score), which is constructed by combining predictive clinicopathologic factors with methylation biomarkers, in two retrospective cohorts and one prospective cohort. We use the REASON score to identify early stage OSCC patients at high risk for mortality, and determine the survival benefit of different adjuvant treatments. Furthermore, we determine the clinical utility of using brush swabs rather than tissues to perform methylation analysis, with the intent of establishing a workflow using noninvasive brush biopsy and the REASON score to predict mortality risk at the time of diagnosis.

PI_NAMEs: VIET, CHI T. (contact)

PROGRAM_OFFICER_NAME: CHOU, ALICIA YESIU

PROJECT_TERMS: Adjuvant Therapy;American;Biological Markers;Biopsy;carcinogenesis;chemoradiation;chemotherapy;Clinical;clinical decision-making;Clinical Laboratory Improvement Amendments;Clinical Research;Clinical Treatment;cohort;Data;Death Rate;Diagnosis;Early identification;Early treatment;Enrollment;Epigenetic Process;epigenome-wide association studies;Excision;Fingerprint;Formalin;Genes;Goals;high risk;Histologic;improved;Individual;Institution;Legal patent;malignant mouth neoplasm;Malignant Neoplasms;Methylation;methylation biomarker;Modality;Molecular;molecular marker;Morbidity - disease rate;mortality;mortality risk;mouth squamous cell carcinoma;Neck Dissection;Needs Assessment;Oral Stage;overtreatment;Paraffin Embedding;Pathway Analysis;Patients;Performance;prognostic;Prognostic Marker;prognostic performance;prognostic value;prospective;Prospective cohort;Radiation therapy;Retrospective cohort;Risk;Risk Assessment;risk prediction;Stage at Diagnosis;survival outcome;Swab;Techniques;Testing;The Cancer Genome Atlas;Time;Tissue Embedding;Tissues;Tumor stage;Validation;validation studies

PROJECT_TITLE: The REASON Score: An Epigenetic And Clinicopathologic Score to Predict Risk of Poor Survival in Early Stage Oral Squamous Cell Carcinoma Patients

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: OSKARSSON, BJORN E (contact)

PROJECT_TERMS: Affect;ALS patients;Amyotrophic Lateral Sclerosis;Animals;Autopsy;Biological;Biological Markers;biomarker discovery;Blood;Blood specimen;Brain;C9ORF72;Caring;Catalogs;Cerebrospinal Fluid;Clinic;Clinical;Clinical Data;clinical phenotype;Collaborations;Collection;Data;Data Collection;Databases;Defect;Disease;disease model;Drug or chemical Tissue Distribution;Evaluation;experience;familial amyotrophic lateral sclerosis;Family;Family member;Foundations;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;General Hospitals;Generations;Genes;Genetic;Genetic Transcription;Genotype;Glass;Harvest;Human;human tissue;In Vitro;induced pluripotent stem cell;Inherited;Institution;Institutional Review Boards;Letters;Life;Liquid substance;Location;Massachusetts;Molecular;Molecular Profiling;Mutation;Nerve Degeneration;Neurodegenerative Disorders;neuropathology;Nuclear Pore;Participant;Pathway interactions;Patients;Persons;Phase;Phenotype;Program Research Project Grants;Proteins;Proteomics;Protocols documentation;recruit;Research Activity;Research Personnel;Research Project Grants;Resources;Sampling;screening;searchable database;Site;Skin;Source;Specimen;Spinal Cord;sporadic amyotrophic lateral sclerosis;System;Tissue Banks;Tissue Sample;Tissues;United States National Institutes of Health;Validation;Visit

PROJECT_TITLE: Core B


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: GENDRON, TANIA FRANCE (contact)

PROJECT_TERMS: Address;Amyotrophic Lateral Sclerosis;Animals;Antisense Oligonucleotides;astrogliosis;Autopsy;Behavior;bench to bedside;Biochemical;Biological Markers;Biological Models;biomarker development;Brain;brain tissue;C9ALS;C9FTD;c9FTD/ALS;C9ORF72;candidate marker;Cerebrospinal Fluid;Clinic;Clinical;Clinical Research;Clinical Trials;Cognition;Collection;Cytoplasm;Data;Detection;Development;Diagnostic;Dipeptides;Disease;Disease Progression;effective therapy;Enrollment;Evaluation;frontotemporal lobar dementia amyotrophic lateral sclerosis;Genes;Genetic;Genetic Transcription;Genotype;Gliosis;Harvest;Histopathology;Home;Human;human tissue;Immunoassay;Immunohistochemistry;improved;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;insight;Investigation;Lead;Length;Life;Light;Link;Measures;member;Methods;Molecular;mRNA Expression;Mus;Muscle Weakness;Muscular Atrophy;Nerve Degeneration;neurofilament;Neuronal Differentiation;neuropathology;new therapeutic target;novel marker;Nuclear Pore Complex Proteins;participant enrollment;Pathologic;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;patient stratification;Patients;Peripheral;pharmacodynamic biomarker;Phenotype;Phosphorylation;Plasma;Play;Process;Production;Prognosis;protein TDP-43;Proteins;Proteome;Proteomics;Research Personnel;Research Project Grants;Resources;RNA;Role;Sampling;Series;Services;Spinal Cord;success;survival prediction;Testing;Therapeutic;therapeutic biomarker;therapeutic target;Tissue Sample;Tissues;trait;transcriptome;transcriptomics;Translations;Treatment outcome;Validation;validation studies;Western Blotting;Work

PROJECT_TITLE: Core C


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative The proposed study is highly significant and relevant to human health: (1) this study would provide better understanding of the biology of NINJ1 and NINJ2 by elucidating how NINJ1 and NINJ2 modulate p53-depedent tumor suppression; (2) The study would reveal a novel role of p53 in pyroptosis through regulating the NLRP3 inflammsome; (3) This study would reveal whether the NINJ1/NINJ2 pathway can be targeted to kill tumor cells carrying wild-type p53.

PI_NAMEs: CHEN, XINBIN  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: alpha helix;Amino Acid Sequence;angiogenesis;Apoptosis;Biological;Biology;Breast Cancer Cell;cancer type;Cell Adhesion Molecules;Cell Aging;Cell Cycle Arrest;Cell Death;cell growth;Cell Migration Inhibition function;cell motility;Cessation of life;Chronic;Complex;Data;Databases;Development;DNA Damage;drug development;Embryo;Exposure to;extracellular;Extracellular Domain;Family;Feedback;Fibroblasts;Genes;Genome;Growth;Health;Human;Hydrophobicity;Immune response;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Invaded;Malignant Neoplasms;MCF7 cell;migration;mRNA Translation;Mus;Mutation;N-terminal;Neoplasm Metastasis;neoplastic cell;nerve injury;Nerve Regeneration;Neurons;novel;novel anticancer drug;overexpression;Pathologic Processes;Pathway interactions;Peptides;Pilot Projects;Play;Predisposition;Proteins;Publishing;Regulation;Repression;Role;Schwann Cells;Signal Transduction;Spinal Ganglia;Stress;systemic inflammatory response;Testing;The Cancer Genome Atlas;Therapeutic;Therapeutic Agents;therapeutic target;TP53 gene;transcription factor;Transmembrane Domain;tumor;tumor progression;Tumor Promotion;Tumor Suppression;tumorigenesis;Up-Regulation

PROJECT_TITLE: The Mechanism and Therapeutic Potential of Targeting the Ninjurin Pathway for Tumors Carrying Wild-Type p53

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Data Science;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

PROJECT_TERMS: Address;Adoption;Alzheimer's Disease;analytical method;Antisense Oligonucleotides;Bioinformatics;Biological;biological systems;biomarker identification;Biostatistics Core;C9ALS;C9ORF72;cell type;Cells;Clinical;Clinical Data;Communities;Confounding Factors (Epidemiology);Data;Data Analyses;Data Analytics;data dictionary;data exchange;data exploration;data harmonization;data integration;Data Reporting;Data Set;data standards;data visualization;Defect;Descriptor;design;Diagnosis;Disease;disease prognosis;Disease Progression;frontotemporal lobar dementia amyotrophic lateral sclerosis;functional genomics;Genes;Genomic approach;Human;Individual;Infrastructure;Methods;Modeling;Molecular;Molecular Profiling;mouse model;multidimensional data;Multiomic Data;multiple datasets;Mus;Nerve Degeneration;Network-based;Neurodegenerative Disorders;neuropathology;new therapeutic target;nucleocytoplasmic transport;Pathology;patient subsets;Peptides;power analysis;Pre-Clinical Model;Process;protein TDP-43;Proteins;Proteomics;Publishing;Research Personnel;risk variant;Sample Size;Sampling;Secure;Sequence Alignment;Standardization;Statistical Models;System;Tissues;Transcript;transcriptomics;Variant;Visualization;web portal;web server;Work

PROJECT_TITLE: Core D


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Neurodegenerative;Neurosciences;Rare Diseases

PI_NAMEs: FRYER, JOHN DAVID (contact)

PROJECT_TERMS: Address;Affect;Amyotrophic Lateral Sclerosis;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Autopsy;Behavior;Behavioral;Brain;Brain region;brain tissue;C9ALS;c9FTD/ALS;C9ORF72;Cell Nucleus;cell type;Cells;Clinic;cohort;Collaborations;Collection;Data;Dipeptides;Disease;Disease Pathway;experimental study;frontotemporal lobar dementia amyotrophic lateral sclerosis;gain of function;Gene Expression Profile;Genes;Genetic;Genetic Transcription;Human;human tissue;In Situ Hybridization;Individual;Mediating;Modeling;Molecular;Motor Cortex;mouse model;Mouse Protein;Mus;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;neuroinflammation;Neuronal Injury;Neurons;neuropathology;novel;Nuclear RNA;Outcome Measure;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Peptides;Predisposition;Prevention trial;programs;Proteins;Proteomics;Research Design;response;RNA;RNA metabolism;RNA-Binding Proteins;Sampling;Shapes;Signal Transduction;single nucleus RNA-sequencing;Spinal Cord;sporadic amyotrophic lateral sclerosis;targeted treatment;Testing;therapeutic target;Tissues;Toxic effect;Transcript;transcriptome sequencing;Translations;treatment group;treatment trial

PROJECT_TITLE: Project 1


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TERMS: Amyotrophic Lateral Sclerosis;Antisense Oligonucleotide Therapy;Bioinformatics;Biological;Biological Models;Biology;Biostatistics Core;Brain;brain tissue;C9ALS;C9FTD;c9FTD/ALS;C9ORF72;cell type;Cells;Cellular Stress;Central Nervous System;Clinical;Clinical Data;Consensus;Data;data modeling;Defect;Dipeptides;Disease;Event;experimental study;Exposure to;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Gene Expression;Genetic;Histologic;Human;Human Characteristics;human induced pluripotent stem cells;Impairment;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;inhibitor;insight;Link;Liquid substance;Mediating;Membrane;Molecular;Motor;Motor Neurons;mouse model;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;Neuronal Injury;Neurons;novel strategies;novel therapeutic intervention;Nuclear Pore Complex;Nuclear Pore Complex Proteins;nucleocytoplasmic transport;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;pharmacologic;Phase Transition;Phenotype;Process;Production;protein expression;Proteins;Proteomics;repaired;RNA;Role;Severities;Specificity;Spinal;Stress;stress granule;Structure;Therapeutic Intervention;transcriptome;transcriptomics;Translations;Validation;validation studies

PROJECT_TITLE: Project 2


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TERMS: ALS patients;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Amyotrophic Lateral Sclerosis Pathway;Animals;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Autopsy;Biological Markers;biomarker discovery;Brain;brain control;C9ALS;c9FTD/ALS;C9ORF72;candidate identification;candidate marker;Cell model;Cerebrospinal Fluid;Clinic;Clinical;clinical biomarkers;clinical phenotype;Clinical Trials;Communities;comparative;Cross-Sectional Studies;Data;Data Set;Disease;Disease Pathway;Disease Progression;Exhibits;familial amyotrophic lateral sclerosis;Family member;Frontotemporal Dementia;Functional disorder;Funding;Future;Gene Silencing;General Population;Genetic;genetic risk factor;Goals;Human;human disease;In Vitro;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Label;Link;longitudinal analysis;Mass Spectrum Analysis;Measurement;Measures;Methods;Modeling;Molecular Analysis;Motor Cortex;mouse model;Mus;Mutation;Nature;Nerve Degeneration;Network-based;Neurodegenerative Disorders;Neurons;next generation;novel marker;novel therapeutic intervention;Pathogenesis;Pathogenicity;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Persons;Pharmaceutical Preparations;Phenotype;Population;Prevention;protein expression;Proteins;proteomic signature;Proteomics;Publishing;Reproducibility;Research;Research Personnel;response;RNA;Sampling;Science;sporadic amyotrophic lateral sclerosis;Subgroup;success;Surrogate Markers;Syndrome;Systems Biology;targeted biomarker;Time;Tissues;Transcript;transcriptomics;treatment response;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Project 3


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Jaw movements in speech and mastication rely on stable tendon-bone attachments that are zonally organized into tendon, fibrocartilage, mineralized fibrocartilage, and bone; however, very little is known about how this graded attachment tissue develops. This proposal investigates a developmental mechanism that acts on tendon-bone attachment progenitors to specify tendon over cartilage cell/bone cell fate. Knowledge gained from this study will lend insights into how tendon cell fate is established, which has implications for designing developmentally inspired strategies for tendon attachment repair and understanding jaw tendon pathologies.

PI_NAMEs: MERRILL, AMY E (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Affect;bone;bone cell;Cartilage;cartilage cell;Cell Fate Control;cell type;Cells;Chondrocytes;Cleavage Under Targets and Release Using Nuclease;Color;Congenital Disorders;Data;design;Development;FGFR2 gene;Fibrocartilages;Fluorescence;Future;Gene Dosage;Genes;Genetic;Genetic Transcription;Genomics;Hybrid Cells;Hybrids;In Situ Hybridization;insight;Jaw;Jaw Abnormalities;jaw movement;Knowledge;Ligands;Limb structure;Mastication;Mesoderm;mineralization;Modeling;Molecular;Morphology;mouse genetics;mouse model;Mus;Neural Crest Cell;notch protein;novel;Osteoblasts;osteogenic;Output;Pathology;Pattern;Physiologic Ossification;Population;Positioning Attribute;progenitor;Property;Regulation;repaired;Repression;scleraxis;Series;Signal Induction;Signal Transduction;single molecule;single-cell RNA sequencing;skeletal;Specific qualifier value;Speech;Stem Cell Development;stem cell differentiation;stem cell fate;System;Tendon structure;Testing;Tissues;Transcriptional Regulation;Up-Regulation;Venus

PROJECT_TITLE: Developmental regulation of tendon-bone connectivity in the jaw

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: DK

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Kidney Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE In the U.S. alone, up to 26 million people have chronic kidney disease, over 460,000 people are on dialysis, and 100,000 people await kidney transplants with 3,000 new patients added monthly. Biomanufacturing functional kidney tissues for therapeutic use may provide a potential solution to this growing problem.

PI_NAMEs: LEWIS, JENNIFER A. (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: 3-Dimensional;absorption;Address;Affect;Biomanufacturing;Biomedical Engineering;bioprinting;blood filter;Blood Vessels;capillary bed;Chronic Kidney Failure;Coculture Techniques;Complex;density;Developmental Biology;Devices;Dialysis procedure;directed differentiation;disease model;Distal;Drainage procedure;Duct (organ) structure;Ductal Epithelial Cell;Electrolytes;End stage renal failure;Engineering;Epithelium;Excretory function;Exhibits;experimental study;Extracellular Matrix;Filtration;fluid flow;Foundations;Generations;glomerular filtration;glomerular function;Goals;Heterogeneity;Homeostasis;Human;human pluripotent stem cell;human stem cell-derived;human stem cells;In Vitro;in vivo;Individual;induced pluripotent stem cell;Kidney;Kidney Diseases;Kidney Transplantation;Lead;Liquid substance;manufacture;Methods;Micropuncture;Modeling;Morbidity - disease rate;mortality;Nephrons;Nutrient;Organ;Organ Donor;Organ Transplantation;Organogenesis;Organoids;Output;Oxygen;Patients;Perfusion;Persons;Physiological;Population;Printing;Production;Protocols documentation;Renal function;Renal Replacement Therapy;Renal Tissue;Research;self assembly;shear stress;societal costs;stem cell derived tissues;stem cells;Structure;success;System;Technology;Therapeutic;Therapeutic Uses;tissue repair;Tissue Transplantation;Tissues;Transplantation;Tubular formation;Ureter;urinary;Validation;Vascularization;Venous;wasting;Xenobiotics

PROJECT_TITLE: Ex Vivo Generation of Functional  Kidney Tissues for Transplantation


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Pediatric;Prevention;Primary Health Care;Sleep Research;Social Determinants of Health;Telehealth

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: NARRATIVE The proposed research is relevant to public health because the prevalence of insufficient sleep and obesity in childhood are excessively high. Pediatricians should promote sleep as part of obesity prevention efforts, but primary care providers currently lack the necessary tools to promote sleep. This project aims to engineer a mobile health platform for the pediatric care setting to promote sleep for obesity prevention and is relevant to the NICHD’s mission to enhance the lives of children and adolescents, and is especially relevant to a NICHD’s Child Development and Behavior Branch high-priority research area to support research on behavioral and health promotion interventions within pediatric primary care.

PI_NAMEs: MITCHELL, JONATHAN ANDREW (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Academy;Achievement;Address;Adolescent;American;Area;Attention;Behavioral;behavioral economics;behavioral sleep intervention;Black race;Body mass index;Cardiovascular Diseases;Child;Child Behavior;Child Development;Child health care;Childhood;Clinical;Communication;Consult;contextual factors;Data;Data Collection;design;dietary;digital;digital health;digital solutions;Dual-Energy X-Ray Absorptiometry;effective intervention;Effectiveness;effectiveness evaluation;Energy Intake;Engineering;Enrollment;Ensure;Equity;Ethnic Origin;Evaluation;excessive weight gain;Experimental Designs;Family;Fatty acid glycerol esters;Feedback;follow-up;Future;Goals;Health;health equity;Health Promotion;high body mass index;Home;Hour;improved;improvement on sleep;Incentives;Incidence;indexing;Individual;innovation;insight;Intervention;junior high school;Knowledge;Lead;Measures;Medicine;mHealth;Mission;mobile computing;Morbidity - disease rate;mortality;multiphase optimization strategy;National Institute of Child Health and Human Development;neighborhood disadvantage;Neighborhoods;Obesity;Obesity associated cardiovascular disease;obesity in children;obesity prevention;obesity risk;Outcome;Parents;pediatrician;Pediatrics;Phase;point of care;Polysomnography;Prevalence;prevent;Primary Care;primary care provider;primary care setting;primary outcome;prototype;Public Health;Race;Randomized;Recommendation;remote delivery;remote monitoring;Research;Research Personnel;Research Priority;Research Support;Resources;Role;Running;sex;Sleep;Sleep Deprivation;sleep health;sleep pattern;sociodemographic factors;sociodemographic group;sociodemographics;telehealth;Telemedicine;Testing;theories;Time;tool;Variant;Work;Youth

PROJECT_TITLE: Optimizing a Mobile Health Platform for Sleep Promotion and Obesity Prevention in Children

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Infectious Diseases;Mental Health;Pediatric;Prevention;Substance Misuse

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Using the most diverse, prospectively studied, multi-national sample to date, this study will have major public health implications in informing scientific understanding of predictors of adjustment during early adulthood, a developmental period characterized by high morbidity and mortality due to mental health problems, substance use, and other largely preventable causes, as well as opportunities for positive adaptation. The work is especially timely because we will examine the impact of COVID-related disruptions in education, work, and other important domains on young adults’ subsequent adjustment. This work will inform programming and policy to improve population health and well-being by identifying novel targets for prevention and intervention to advance the Sustainable Development Goals adopted by the United Nations to guide the international development agenda through 2030.

PI_NAMEs: LANSFORD, JENNIFER E (contact)

PROJECT_TERMS: 8 year old;Address;Adolescence;Adolescent;Adopted;Adult;Adult Children;Age;aged;antisocial behavior;Anxiety;Attitude;Behavior;behavioral study;Belief;Binding;Child;Child Rearing;Childhood;China;Colombia;Competence;computerized;Conflict (Psychology);Country;COVID-19;COVID-19 impact;COVID-19 risk;cultural values;Data;Decision Making;Development;disability burden;Disease;Education;emerging adult;Etiology;expectation;experience;Family;Family Relationship;Fathers;Funding;Goals;Health;Heterogeneity;high risk;Homicide;improved;Individual;Informal Social Control;information processing;International;Intervention;Interview;Italy;Jordan;Kenya;Life Cycle Stages;Longitudinal Studies;longitudinal, prospective study;Measures;Mediating;Mediation;Mediator;Mental Depression;Mental Health;middle age;Modeling;Morbidity - disease rate;mortality;mortality risk;Mothers;novel;Outcome;pandemic disease;Parent-Child Relations;Parents;Participant;Pathway interactions;Pattern;Personal Satisfaction;Philippines;Policies;population health;Prevention;Process;Prospective Studies;protective factors;Public Health;recruit;Research;Rewards;Risk;Risk Factors;Risk Taking;Sampling;Sexually Transmitted Diseases;social;Socialization;Substance abuse problem;substance use;Substance Use Disorder;Sustainable Development;Sweden;Thailand;United Nations;United States;vehicular accident;Work;young adult

PROJECT_TITLE: Childhood, Adolescence, and Covid-Related Risk and Protective Factors in the Development of Adjustment in Early Adulthood Across Cultures

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Biotechnology;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: SAINT LOUIS

ORG_DEPT: GENETICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Neurodevelopmental disorders (NDDs) affect >1% of the population and are comprised of multiple phenotypes including autism, intellectual disability, and other developmental delays. While considerable efforts have been made to understand the role of rare protein-coding variation in NDDs, there is less known about the contribution of rare noncoding variation. In proposed studies, we will further assess the overall enrichment seen for this type of variation and begin to identify specific noncoding regions with enrichment of rare noncoding variants in NDDs.

PI_NAMEs: TURNER, TYCHELE NAOMI (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA JOY

PROJECT_TERMS: Affect;Architecture;autism spectrum disorder;Biological Assay;causal variant;Characteristics;Code;Data;Data Set;Development;Developmental Delay Disorders;Disease;DNA;dosage;Elements;Enhancers;exome sequencing;Exons;Family;follow-up;Gene Expression;Genes;Genetic;genetic architecture;Genetic Predisposition to Disease;genetic variant;Genetic Variation;Genome;Genome Mappings;genome sequencing;genome-wide;genomic data;Goals;Human;Human Genome;improved;In Vitro;Individual;Infrastructure;insertion/deletion mutation;insight;Intellectual functioning disability;Maps;Methods;Micro Array Data;Mutation;Neurodevelopmental Disorder;Nucleic Acid Regulatory Sequences;Nucleotides;Open Reading Frames;Phenotype;Phylogenetic Analysis;Population;Positioning Attribute;Printing;programs;promoter;Proteins;Publications;reference genome;Reporter;Reporter Genes;Resources;Role;Sample Size;Signal Transduction;Single Nucleotide Polymorphism;Testing;transmission process;Untranslated RNA;Variant;whole genome;Work

PROJECT_TITLE: Noncoding mutations in neurodevelopmental disorders

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Prevention

ORG_DEPT: SOCIAL SCIENCES

PHR: PROJECT NARRATIVE The proposed study is relevant to public health because it addresses the implementation of evidence-based programs and policies (EBPPs) to prevent and control cancer within local communities across the US. Developing effective strategies to encourage local health departments’ (LHD) use of EBPPs in an ongoing manner is critical to the potential of these programs and policies to reduce burden, such as by leveraging the expertise of LHDs’ existing, local-level partnerships with academics. A project on the scale proposed has the potential to begin to shift the paradigm on how research can be quickly and effectively translated to those in the best position to use the evidence, such as LHDs.

PI_NAMEs: MAZZUCCA-RAGAN, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: KOBRIN, SARAH

PROJECT_TERMS: Academic support;Address;Adopted;Adoption;arm;Cancer Burden;Cancer Control;cancer prevention;Characteristics;Chronic Disease;Collaborations;Communities;contextual factors;Data Collection;Decision Making;design;Diet;Dissemination and Implementation;Early Diagnosis;Education;effectiveness testing;evidence base;Evidence based program;Exploration, Preparation, Implementation, and Sustainment;Funding;Goals;Health;Health education;implementation evaluation;implementation facilitation;implementation research;improved;Individual;innovation;Interview;Joints;Link;Localized Disease;Malignant Neoplasms;Methods;Modeling;modifiable risk;organizational climate;Phase;Physical activity;Policies;Population;Positioning Attribute;prevent;Process;programs;Public Health;Public Health Practice;Randomized;randomized trial;Research;Research Personnel;Research Project Grants;research to practice;Resources;Risk Factors;skills;Structure;Students;Surveys;Testing;Tobacco use;Training;Translating;Translational Research;United States;Work

PROJECT_TITLE: Improving cancer prevention and control through academic-local public health department partnerships

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative: The proposed research focuses on the upstream regulation of barrier function mediated by Foxo1, β-catenin and E-cadherin that may be modulated by periodontitis or peri-implantitis. We will examine how they contribute to formation of tight junctions under conditions of interstitial pressure, attachment to titanium and inflammatory cues. In vivo mouse studies will further establish whether periodontal inflammation alters the localization of key molecules that maintain epithelial integrity, which will be further examined in tissue from periodontitis and peri-implantitis patients.

PI_NAMEs: ALIMPERTI, STELLA  (contact);GRAVES, DANA T

PROJECT_TERMS: Ablation;Address;Affect;Agonist;Animal Experiments;Bacteria;Behavior;beta catenin;Binding;Biological Models;Cell membrane;Cell Nucleus;Cells;Connective Tissue;Cues;Cytoplasm;Data;Devices;Disease;E-Cadherin;Epithelial Attachment;Epithelium;Escherichia coli;Event;Experimental Models;FOXO1A gene;Fusobacterium nucleatum;Genes;Gingiva;Homeostasis;Human;human tissue;Implant;improved;In Vitro;in vivo;Inflammation;Inflammatory;insight;interstitial;keratinocyte;knock-down;Link;Maintenance;Measures;mechanical force;mechanical pressure;Mechanical Stimulation;Mechanical Stress;Mediating;Metals;Mouth Diseases;Mus;novel;Oral;oral bacteria;oral cavity epithelium;Patients;peri-implantitis;Periodontitis;pressure;Process;Regulation;Regulatory Pathway;Research;RNA Interference;Role;Signal Induction;Signal Transduction;Site;spatiotemporal;Surface;System;Testing;Tight Junctions;Tissues;Titanium;TLR4 gene

PROJECT_TITLE: Regulation of epithelial barrier

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: MD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: MIAMI

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

PHR: FIU-RCMI Overall Project Narrative Florida International University (FIU), our emerging preeminent research program in health disparities, our early-stage investigators, and our South Florida minority community partners all have benefitted from the NIMHD-funded Research Center in Minority Institutes at FIU. We are enthusiastic about submitting this competitive renewal proposal for our Center, which builds upon our achievements, refines our approaches to early-stage investigator mentoring, community research partnership, and faculty recruitment, and broadens our scope. Our scientific focus areas will include basic biomedical research, behavioral research and population science, and clinical/health services research, with one R01-equivalent project in each area.

PI_NAMEs: WAGNER, ERIC F (contact)

PROGRAM_OFFICER_NAME: GOGINENI, ARUNDHATI

PROJECT_TERMS: Achievement;Address;Adopted;Adult;Agrochemicals;AIDS prevention;Alzheimer's Disease;Area;Award;Behavioral;Behavioral Research;Biomedical Research;Black race;cancer health disparity;career development;Child;Clinical;Clinical Research;Cognition;Communities;community organizations;community partners;community research;COVID-19;COVID-19 disparity;Disease;Environment;Extramural Activities;Faculty;Faculty Recruitment;farm worker;Florida;Fostering;Funding;Goals;Growth;Health;health disparity;health disparity populations;health equity;health inequalities;Health Services Research;Hispanic;HIV;HIV disparities;Infrastructure;Institution;International;Latinx;member;Mentors;Mentorship;microbiome;middle age;Minority;minority communities;minority disparity;minority health;minority health disparity;Minority-Serving Institution;National Institute on Minority Health and Health Disparities;Persons;Pilot Projects;Population;Population Sciences;Positioning Attribute;Postdoctoral Fellow;Precision cancer therapy;precision medicine;Prevention approach;programs;Recording of previous events;Research;Research Personnel;Research Support;Research Training;Sleep;substance use;success;underserved community;United States National Institutes of Health;Universities;Vision

PROJECT_TITLE: The FIU Research Center in a Minority Institution (FIU-RCMI)


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Achievement;Advisory Committees;Applications Grants;Collaborations;college;Communities;community advisory board;community engagement;community partnership;design;Development;Educational Activities;Educational workshop;Ensure;Evaluation;Event;Faculty;Faculty Recruitment;Florida;Funding;Goals;graduate student;Growth;Health Disparities Research;health disparity;health disparity populations;Health Sciences;Home;Incentives;Infrastructure;innovation;Institution;inter-institutional;Joints;Leadership;Logic;member;Mentors;Mentorship;minority health;minority health disparity;Minority-Serving Institution;Modeling;Monitor;National Institute on Minority Health and Health Disparities;Outcome;Peer Review;Pilot Projects;Postdoctoral Fellow;Process;Productivity;Publications;recruit;Research;research and development;Research Personnel;Resources;Role;satisfaction;Scholarship;Schools;Science;Structure;success;symposium;Training;underserved community;Universities;vulnerable community;Work

PROJECT_TITLE: Administrative Core


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: NARRATIVE The complex mechanisms that regulate local blood flow supply to active neurons are not completely understood. Dysregulation of these mechanisms is associated with cognitive impairment and dementia, a global public health issue with significant social and economic implications. In this study, we utilize a novel approach of multiscale mathematical modeling together with experimentation to investigate how neurons communicate to the vasculature in health and in disease.

PI_NAMEs: TSOUKIAS, NIKOLAOS MICHAEL (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Action Potentials;Affect;Alzheimer's Disease;Animal Model;arteriole;Astrocytes;Biophysics;Blood;Blood capillaries;Blood flow;blood perfusion;Blood Vessels;Brain;Brain Pathology;Capillary Endothelial Cell;Cell Communication;Cell membrane;Cell model;cell type;Cells;Cerebral small vessel disease;Cerebrovascular Circulation;Cerebrum;Chemicals;Cognition Disorders;Communication;Complex;Data;Defect;Dementia;Diameter;Disease;economic implication;Endothelium;Environment;experimental study;extracellular;Failure;Feedback;feeding;Health;Homeostasis;Hyperemia;Impaired cognition;Impairment;insight;Investigation;inward rectifier potassium channel;Ions;Lead;Link;Location;mathematical model;Mathematics;Mediating;Mediator;member;Microcirculation;Microscopic;Microvascular Dysfunction;Modeling;multi-scale modeling;neuroimaging;Neurons;neurotransmission;neurovascular coupling;novel strategies;Nutrient;Oxygen;parenchymal arterioles;Perfusion;pharmacologic;Preparation;pressure;Process;Public Health;Recovery;regenerative;Relaxation;Research;Resources;response;Role;Scanning;Seminal;sensor;Signal Pathway;Signal Transduction;simulation;Smooth Muscle Myocytes;social implication;Stroke;targeted treatment;Techniques;Testing;theories;Tissues;vascular cognitive impairment and dementia;Vascular Endothelium;Vascular Smooth Muscle;Waste Products;Work

PROJECT_TITLE: Cerebral Microvascular Signaling and Neurovascular Coupling: An Integrated Approach to Investigate VCID

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Clinical Research;Genetics;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Orphan Drug;Pediatric;Pediatric - AIDS;Pediatric Cancer;Precision Medicine;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

PI_NAMEs: AZZAM, DIANA  (contact)

PROJECT_TERMS: actionable mutation;Address;Adopted;Adult;Advanced Malignant Neoplasm;anti-cancer research;Area;Biological Assay;Biology;Black Populations;Black race;Brain;cancer health disparity;Cancer Patient;cancer recurrence;cancer survival;cancer therapy;cancer type;Cause of Death;Central Nervous System Neoplasms;Child;Childhood;Childhood Cancer Treatment;childhood sarcoma;Clinical;clinical application;clinical decision-making;Clinical Management;Clinical Trials;Collaborations;Data;Detection;Diagnosis;Disease;Drug Combinations;Drug Screening;drug sensitivity;Enrollment;ethnic disparity;ethnic minority;ethnic minority population;Ethnic Origin;FDA approved;Florida;Genetic;genomic profiling;health equity promotion;Health Services Accessibility;Hispanic;Hispanic Populations;Hospitals;improved;Individual;individual patient;individualized medicine;Inequality;infancy;Intervention;Label;Length;Libraries;Machine Learning;Malignant Childhood Neoplasm;Malignant Neoplasms;Medical center;minority children;Minority Groups;minority patient;Minority-Serving Institution;Molecular;Molecular Profiling;multiple omics;Mutation;Mutation Analysis;Not Hispanic or Latino;novel;novel therapeutics;Oncology;Outcome;patient population;Patient-Focused Outcomes;Patients;Pediatric Hospitals;pediatric patients;personalized cancer therapy;personalized intervention;personalized medicine;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Phenotype;Population;Positioning Attribute;precision medicine;precision oncology;Property;Race;racial disparity;racial diversity;racial minority;racial minority population;Recommendation;Recurrence;Refractory;refractory cancer;Relapse;relapse patients;Research;Research Project Grants;response;survival outcome;targeted treatment;Testing;Time;tool;Toxic effect;transcriptomics;treatment disparity;Treatment Efficacy;treatment response;Tumor Tissue;United States;Work

PROJECT_TITLE: Adopting a functional precision medicine approach to reduce cancer disparities in Hispanic and Black children of Miami


NIH_SPENDING_CATS: Genetics;Kidney Disease

ORG_CITY: PITTSBURGH

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: AKI accounts for ~$10 billion in US healthcare costs and results in 2 million deaths annually worldwide. There are no effective clinical therapies that reduce the severity of injury or accelerate recovery after AKI. In this proposal, we will confirm HDAC8 as a therapeutic target for promoting productive repair after AKI, and develop novel HDAC8 inhibitors with improved potency, drug-like properties, and efficacy, that have the potential to advance into clinical trails to treat AKI.

PI_NAMEs: DAVIDSON, ALAN ;DE CAESTECKER, MARK P.;HUKRIEDE, NEIL A (contact);HURYN, DONNA M

PROJECT_TERMS: Acceleration;Acetylation;Acute Renal Failure with Renal Papillary Necrosis;Affect;analog;Biological Assay;Cell Culture Techniques;Cell Cycle;Cell Cycle Kinetics;Cell Cycle Progression;Cell Cycle Regulation;Cells;Cessation of life;Characteristics;Chromatin Loop;Chronic Kidney Failure;Clinical;Clinical Trials;cohesin;cohesion;CSPG6 gene;Data;Deacetylation;design;Disease Progression;DNA Damage;DNA Repair;Drug Kinetics;Epithelial Cells;epithelial repair;G1 Phase;Generations;Genes;genetic approach;Genetic study;Goals;HDAC8 gene;Health;Health Care Costs;Histone Deacetylase;Histone Deacetylase Inhibitor;Human;Hypertension;improved;In Vitro;in vivo;inhibitor;injured;Injury;Injury to Kidney;Kidney;Kidney Failure;Mammals;Mediating;Metabolism;Mitosis;Modeling;mouse model;multidisciplinary;Mus;novel;Organoids;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology Study;pharmacophore;Play;preclinical development;Prodrugs;Productivity;Property;Recovery;repaired;Role;Series;Severities;Sister Chromatid;Stimulus;Structure;Testing;Therapeutic;therapeutic target;Time;translation to humans;Tubular formation;Work;Zebrafish

PROJECT_TITLE: Therapeutic Optimization of Productive Repair After Acute Kidney Injury


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Dementia;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Neurodegenerative;Neurosciences;Prevention;Sleep Research;Social Determinants of Health

PI_NAMEs: BURKE, SHANNA L (contact)

PROJECT_TERMS: actigraphy;Adult;Affect;age group;Alzheimer's Disease;Alzheimer's disease risk;Animal Model;biological sex;Brain;circadian;Cognition;Cognitive;cognitive testing;Collection;Communities;community living;County;Data;Data Collection;Dementia;Development;Devices;dysbiosis;Exhibits;fecal metabolome;fecal microbiome;Florida;Funding;Future;gastrointestinal;Genes;gut microbiome;gut microbiota;health disparity;Hispanic-serving Institution;Hormonal;Hormones;Hour;Human;Hydrocortisone;hypothalamic-pituitary-adrenal axis;Immunologics;Impaired cognition;Influentials;innovation;International;Intervention;Investigation;late life;Latinx;Latinx population;Life Cycle Stages;Longitudinal Studies;machine learning algorithm;Measures;Mediation;metabolic profile;microbial;microbial composition;Microbiology;microbiome;microbiome analysis;microbiome research;middle age;Minority-Serving Institution;Modeling;modifiable risk;Molecular;National Institute on Minority Health and Health Disparities;Nerve Degeneration;Neurocognitive;Neurologic;novel;Participant;Pathway Analysis;Pathway interactions;Patient Recruitments;Polysomnography;poor sleep;Population;Positioning Attribute;Recommendation;recruit;Research;Research Personnel;Research Project Grants;Resources;Risk Factors;Role;saliva sample;Salivary;Sampling;Signal Transduction;Sleep;sleep behavior;Sleep Disorders;Sleep disturbances;sleep health;sleep pattern;sleep quality;sleep quantity;sociocultural determinant;Statistical Methods;stool sample;Stress;Structure;Symptoms;System;Time;Underrepresented Populations;Universities;Variant;Whole-Genome Shotgun Sequencing;Wrist

PROJECT_TITLE: Microbiome profiles, sleep, and cognition among mid-life Latinx adults


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Infectious Diseases;Microbiome;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: CINCINNATI

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT(NARRATIVE( Clostridium difficile (CD), recently classified by the CDC as one of the top three “urgent” public-health threat organisms, causes significant morbidity and mortality among cancer patients and contributes to chemotherapy treatment-related adverse events. As current approaches to reducing CD infection (CDI) rates are clearly inadequate, there is a critical need to understand the basic science underlying the development of CDI in cancer chemotherapy patients. The studies proposed will expand our knowledge of Clostridium difficile host-microbe interaction in cytotoxic chemotherapy patients with the goal to identify new strategies for preventing CDI.

PI_NAMEs: APEWOKIN, SENU  (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Address;Adverse effects;Adverse event;Affect;Antibiotics;antimicrobial;Award;Basic Science;beta catenin;Bioinformatics;Biological Assay;Biological Models;Biology;Biometry;Cancer Model;Cancer Patient;cancer therapy;career development;Case/Control Studies;Cell Culture Techniques;chemotherapy;Chemotherapy-Oncologic Procedure;Classification;Clinical Trials Design;Clonal Expansion;Clostridium difficile;Clostridium difficile tcdA protein;Complement;Contracts;cytotoxic;Cytotoxic Chemotherapy;Development;Disease;Dose;Ensure;Enzyme-Linked Immunosorbent Assay;Epithelium;experience;Frustration;Functional disorder;Funding;gastrointestinal infection;Goals;gut microbiota;Hematologic Neoplasms;host-microbe interactions;Human;Immune;Immune response;Immunity;Immunocompetent;Immunogenetics;Immunoglobulins;Impairment;improved;Incidence;indexing;Infection;Infection Control;infection rate;Interruption;Intestines;Knowledge;Link;Malignant Neoplasms;Mediating;Mentors;metagenomic sequencing;Metagenomics;Methodology;Methods;microbial;microbial community;microbiota;Microinjections;Modeling;Molecular Biology;Morbidity - disease rate;mortality;Natural History;Organism;Organoids;Paneth Cells;pathogen;Pathogenicity;Pathology;Patients;Performance;Phylogenetic Analysis;Physicians;Physiology;Pilot Projects;prevent;preventive intervention;Process;programs;Proteins;Public Health;receptor;Reporter;Research;Resistance;response;scaffold;Scientist;Shotgun Sequencing;Structure;Supportive care;Techniques;Testing;Toxin;Training;translational physician;Treatment outcome;treatment strategy;tumor

PROJECT_TITLE: Harnessing Induced Human Intestinal Organoids (iHIOs) and Metagenomics to Unravel Host Immune-microbiota Interactions During Cancer Chemotherapy-associated Clostridium difficile Infections

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Rural Health;Social Determinants of Health

PI_NAMEs: SHEEHAN, DIANA MONTSERRAT (contact)

PROJECT_TERMS: 2019-nCoV;Acquired Immunodeficiency Syndrome;Acute;Address;Area;Behavioral;Biological;Black Populations;built environment;California;care outcomes;Caring;Case Fatality Rates;Censuses;Chronic;Communities;community engagement;community-level factor;comorbidity;Complex;County;COVID-19;COVID-19 diagnosis;COVID-19 disparity;COVID-19 mortality;COVID-19 pandemic;COVID-19 surveillance;Data;Data Science;Data Set;Disparity;Environment;Epidemic;ethnic disparity;Ethnic Origin;experience;Florida;Gender;Goals;health care availability;Health Disparities Research;health disparity;Health Services Accessibility;Healthcare Systems;Herd Immunity;Hispanic Populations;HIV;HIV diagnosis;HIV disparities;HIV Infections;HIV/AIDS;Hospital Mortality;Hospitalization;Hospitals;Human immunodeficiency virus test;Incidence;Individual;Inequity;innovation;Intervention;Link;Minority-Serving Institution;mortality;National Institute on Minority Health and Health Disparities;New York;Not Hispanic or Latino;novel;Outcome;pandemic disease;Persons;Play;Policies;Population Study;Process;Race;racial disparity;Recommendation;Reporting;Reproducibility;Research;Research Priority;Research Project Grants;Resources;Risk Reduction;Role;Rural;SARS-CoV-2 infection;severe COVID-19;social culture;social structure;socioeconomic disparity;socioeconomics;Source;Strategic Planning;structural determinants;Structure;surveillance data;syndemic;System;Texas;theories;transmission process;Treatment outcome;Twin Multiple Birth;United States;United States National Institutes of Health;urban disparity;urban residence;Viral;Virus;Vulnerable Populations

PROJECT_TITLE: Addressing community-level influences of HIV and COVID-19 disparities among people with HIV


NIH_SPENDING_CATS: Kidney Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The goal of this project is to change the treatment paradigm for diseases affecting the podocytes, cells that physically filter the blood to form the urine, by combining therapeutics development with cell-specific delivery to enhance the natural ability of the body to repair and regenerate these highly specialized cells. Accomplishing this requires a dual synchronized approach: (i) replacing lost podocytes from neighboring stem cells to increase their number, and (ii) limiting/reversing damage to the remaining podocytes, however, major knowledge gaps to achieve this goal exist, including our limited knowledge on the molecular factors stimulating PEC self-renewal and podocyte regeneration/repair, as well as options to deliver such factors to specific kidney cell types in vivo. By establishing a pipeline through which we couple cutting-edge cell delivery molecules called nanobodies to recently-discovered factors that protect damaged podocytes and promote the replacement of lost ones, we will create a new family of therapeutic entities that prevent disease in both mouse and human kidney tissue, by harnessing the body's natural abilities to regenerate this vulnerable kidney compartment.

PI_NAMEs: SHANKLAND, STUART JAMES (contact)

PROJECT_TERMS: Affect;Age;Albuminuria;Animal Model;blood filter;causal variant;cell injury;cell type;Cells;Cessation of life;Cicatrix;Clinical;Clinical Data;Clinical Trials;Deterioration;Disease;efficacy evaluation;Epithelial Cells;epithelial stem cell;Experimental Designs;Family;Focal and Segmental Glomerulosclerosis;Genes;glomerular function;Goals;Human;human data;in vivo;in vivo regeneration;injured;innovation;Innovative Therapy;Kidney;kidney biopsy;kidney cell;Kidney Diseases;Knowledge;Lead;Libraries;Methods;migration;Molecular;Morphology;Mus;nanobodies;Natural regeneration;novel;novel therapeutics;organoid transplantation;Organoids;Parietal;Patients;Peptides;Physiological;podocyte;preclinical development;prevent;Process;Productivity;progenitor;Proliferating;Recombinants;regeneration potential;Renal function;Renal glomerular disease;repaired;Reporter;Research;Research Personnel;Safety;self-renewal;small molecule;stem cells;stemness;targeted delivery;targeted treatment;Technology;Testing;Therapeutic;therapeutic candidate;therapeutic development;Tissues;tool;Transplantation;Urine;Work

PROJECT_TITLE: Cell specific delivery of novel therapies to enhance glomerular regeneration and repair


PI_NAMEs: BURSAC, ZORAN  (contact)

PROJECT_TERMS: Academia;Affect;African American;Alzheimer's Disease;Area;Behavioral;Behavioral Research;Biomedical Research;Biometry;Black race;Career Mobility;Carrying Capacities;Clinical;Collaborations;college;Communities;community engagement;Complex;Core Facility;COVID-19;Data;Data Science;Dedications;Development;Disadvantaged;Disease;Disparity;Education;Educational workshop;Ensure;ethnic minority population;Etiology;Event;evidence base;Faculty;Faculty Recruitment;Florida;Funding Opportunities;Genetic;Geographic Locations;Goals;Health Disparities Research;health disparity;Health equity research;Health Services Research;High Prevalence;Hispanic;HIV/AIDS;improved;Individual;Infrastructure;innovation;Institution;Interdisciplinary Study;laboratory facility;Latino;Latinx;Leadership;Libraries;Machine Learning;Malignant Neoplasms;Measurable;Measures;meetings;Mentors;Mentorship;Methodology;Methods;Minority Groups;Minority-Serving Institution;Mission;Molecular;multi-racial;National Institute on Minority Health and Health Disparities;Needs Assessment;Neurobiology;Not Hispanic or Latino;online resource;Outcome;personalized approach;Pilot Projects;Play;Population Sciences;Prevention;Process;Productivity;professor;programs;Public Health;Publishing;racial minority population;recruit;Reduce health disparities;repository;Research;research and development;Research Methodology;Research Personnel;Research Support;Resources;Role;Science;Services;social;Societies;Strategic Planning;Students;Subgroup;Substance Use Disorder;success;support tools;Surveys;sustainable resource;symposium;Technology;tool;Training;training opportunity;Translational Research;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;ward;Woman;Work;Zoran

PROJECT_TITLE: Research Capacity Core


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Microbiome;Orphan Drug;Pancreatic Cancer;Rare Diseases;Skin Cancer

ORG_DEPT: PATHOLOGY

PHR: Project Description/ Narrative Most cancer patients still fail to respond to current checkpoint blockade immunotherapy, thus understanding the protective immune responses in long-term cancer survivors and studying the cancer immunotherapy resistant mechanisms are urgent. In this proposal, we will further characterize the durable tumor protective immune responses in melanoma survivors with dermal immune-related adverse events (irAE) and expand the study to explore the roles of microbiomes in current immunotherapy resistant cancer types. The findings of this work will reveal the durable, successful anti-tumor immune responses linking the skin irAEs with tumor immunity and provide novel insights into the key immune mechanisms of microbiomes associated long-term tumor elimination.

PI_NAMEs: HAN, JICHANG  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Academia;Affect;anti-tumor immune response;Antigens;Antitumor Response;Area;Blood;Blood Vessels;cancer immunotherapy;Cancer Patient;Cancer Survivor;cancer type;career;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cellular Immunology;cytotoxic CD8 T cells;Dendritic Cells;Dermal;Dermatologist;design;Development;epigenomics;Exanthema;experience;Genomics;Goals;graduate student;Growth;Human;Immune;immune checkpoint blockade;immune resistance;Immune response;immune-related adverse events;Immunologist;Immunotherapeutic agent;Immunotherapy;improved;Inflammatory;insight;interdisciplinary approach;Knowledge;Leadership;Learning;Link;Macrophage;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;malignant stomach neoplasm;Mediating;Medical Oncologist;Melanoma;Melanoma patient;Memory;memory CD4 T lymphocyte;Mentors;metabolomics;microbiome;Molecular;mouse model;neoplasm immunotherapy;neoplastic cell;Norris Cotton Cancer Center;novel;novel therapeutic intervention;Patients;Peritoneum;Phase;Phenotype;Play;Population;Postdoctoral Fellow;Pre-Clinical Model;programs;refractory cancer;Regimen;Regulatory T-Lymphocyte;Research;Research Project Grants;Research Training;Resistance;resistance mechanism;response;Role;single-cell RNA sequencing;skills;Skin;Specificity;success;Surgeon;Survivors;T cell receptor repertoire sequencing;T cell response;T memory cell;T-cell receptor repertoire;T-Lymphocyte;Technical Expertise;Th2 Cells;Training;transcriptomics;Translational Research;treatment strategy;tumor;Tumor Immunity;tumor immunology;tumor microenvironment;Tumor Promotion;Vitiligo;Work

PROJECT_TITLE: Deciphering the role of tumor-macrophage crosstalk during metastatic dissemination to the peritoneum


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: TREPKA, MARY JO  (contact)

PROJECT_TERMS: Address;Applications Grants;Award;Behavioral Research;Biological;Biomedical Research;career development;career networking;chemical resource;Clinical Research;cohort;combat;Communities;community research;Complex;curriculum development;Data;Dedications;Development;Effectiveness;Ensure;Equity;federal policy;Feedback;follow-up;Fostering;Funding;Goals;Grant;Guidelines;Health Disparities Research;health disparity;health disparity populations;Health Promotion;human subject;implementation barriers;improved;innovation;insight;interest;Laboratories;Laws;meetings;member;Mentors;Mentorship;Minority-Serving Institution;Monitor;Output;Peer Review;Phase;Pilot Projects;Policies;Population Research;Procedures;Process;programs;Publications;recruit;Regulation;Research;Research Personnel;Research Project Grants;Resource Sharing;Support System;Training;Underrepresented Populations;United States;United States National Institutes of Health;Universities;Vertebrates;Work;Writing

PROJECT_TITLE: Investigator Development Core


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome;Machine Learning and Artificial Intelligence

ORG_CITY: BOCA RATON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: FLORIDA ATLANTIC UNIVERSITY

PHR: PROJECT NARRATIVE Just like a population of organisms, genome size and composition can change over time via births, deaths, and migrations of large DNA segments. These mutation events result in genomic structural variations among individuals that underlie many important human adaptations, such as color vision, and diseases, such as cancer. The work proposed here seeks to develop and apply powerful new computational and statistical techniques for investigating the outcomes of structural variations in humans and other species, thereby both enhancing our understanding of past evolutionary history and advancing future biomedical research.

PI_NAMEs: ASSIS, RAQUEL  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Animals;Automobile Driving;Biological Assay;Biomedical Research;Birth;Cessation of life;Classification;Color Visions;Communities;Complex;Computer software;Data;Decision Trees;design;Development;Disease;DNA;Drosophila genus;Event;Evolution;follow-up;Future;Gene Deletion;Gene Duplication;Gene Expression;Gene Expression Profile;gene translocation;Genome;genomic variation;Genomics;Goals;Human;human disease;Individual;innovation;interest;Investigation;Learning;Life;Malignant Neoplasms;Mammals;Methods;migration;Modeling;Mutation;Natural Selections;Nature;open source;Organism;Outcome;Pattern;Phylogenetic Analysis;Plants;Play;Poaceae;Population;Recording of previous events;Role;Shapes;statistical and machine learning;Taxonomy;Techniques;Time;Tissues;transcriptomics;Trees;Variant;Work

PROJECT_TITLE: Learning about the evolution of structural variations from genomic and transcriptomic data

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Lung;Orphan Drug;Precision Medicine;Pulmonary Hypertension;Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Pulmonary vascular disease is common and associated with high mortality in patients with heart failure, but the underlying pathobiology is poorly understood. We propose novel methods to identify proteins that contribute to functional status and prognosis in patients with heart failure and pulmonary vascular disease. We also propose new methods to identify and test, in patient-specific trials, repurposed treatments for this condition.

PI_NAMEs: BRITTAIN, EVAN L (contact);HEMNES, ANNA R;MARON, BRADLEY

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Academic Medical Centers;Activities of Daily Living;Address;analytical method;arterial remodeling;Attention;Autopsy;biobank;Biochemical Markers;Biological Markers;Biology;biomarker discovery;Blood capillaries;Blood Vessels;candidate marker;Cardiovascular Diseases;Cessation of life;Clinical;clinical heterogeneity;Clinical Trials;cohort;Collaborations;Complex;Cross-Over Trials;Data;Development;Diagnosis;Disease;endophenotype;Experimental Models;experimental study;Fibrosis;functional status;Genetic;Heart Diseases;Heart failure;hemodynamics;Heterogeneity;high risk;Histologic;Human;human disease;Hypertrophic Cardiomyopathy;improved;in silico;In Situ;Individual;Individual Differences;individual patient;innovation;Left;Lung;Maps;Medicine;Methods;Mission;Molecular;mortality;National Heart, Lung, and Blood Institute;next generation;novel;Outcome;Pathology;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Phenotype;Placebo Control;Plasma;precision medicine;Prognosis;prognostic;prognostication;protein expression;protein protein interaction;Proteins;pulmonary arterial hypertension;Pulmonary arterial remodeling;Pulmonary Heart Disease;Pulmonary Hypertension;pulmonary vascular disorder;Pulmonary Vascular Resistance;pulmonary venous hypertension;Reporting;Research;Safety;Sampling;Severities;sex;System;Testing;therapeutic candidate;therapeutic target;Tissues;transcriptome;treatment response;United Kingdom;United States National Institutes of Health;Validation;Variant;Vascular remodeling;venule;Vulnerable Populations;Work

PROJECT_TITLE: Network Medicine and Systems Pharmacology to Advance Precision Medicine in Combined Pulmonary Hypertension

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-A(05)]


PI_NAMEs: HOSPITAL, MICHELLE MARIE (contact)

PROJECT_TERMS: Address;African American;Automobile Driving;Award;Black race;Caribbean region;Categories;Clinic;Collaborations;Communication;Communications Media;Communities;community academic partnership;community advisory board;community center;community consultation;community engaged research;community engagement;community living;community organizations;community partners;community research;COVID-19;Decision Making;design;Development;Dissemination and Implementation;empowerment;Ensure;Ethics;Extramural Activities;Faculty;Florida;Foundations;Funding;Goals;Grant;Haitian;Health;Health Disparities Research;health disparity;health equity;Healthcare;Hispanic;Human Resources;improved outcome;innovation;International;investigator training;Joints;Knowledge;Latinx;Link;medically underserved;meetings;member;Methods;Minority-Serving Institution;Modeling;novel;outcome disparities;Personal Satisfaction;prevent;Principal Investigator;Process;Program Evaluation;programs;Research;research data dissemination;Research Infrastructure;Research Personnel;Resources;Role;Science;Structure;success;Training;Training Activity;Training and Infrastructure;training opportunity;Trust;underserved community;Universities;vulnerable community;Work

PROJECT_TITLE: Community Engagement Core


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: CHAPEL HILL

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative By continuing to innovate in active learning, engaged mentoring, dynamic research areas, and ongoing self-assessment the Cardiovascular (CV) Epidemiology Training Program at the University of North Carolina seeks to train effective and independent researchers in the disciplines and methods intersecting CV epidemiology. The proposed plan builds on historical strengths of the program and introduces new initiatives to strengthen the training experience. The program's trainees and alumni are exceptionally productive and successful researchers and scholars making important contributions to the field.

PI_NAMEs: ROSAMOND, WAYNE D. (contact)

PROGRAM_OFFICER_NAME: PRICE, CANDICE

PROJECT_TITLE: Cardiovascular Epidemiology Training Grant

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Genetics

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Narrative Deregulation of protein phosphatases is a hallmark of many human diseases. This research plan proposes innovative approaches in proteomics, biochemistry, and cell biology to characterize the regulation of the holoenzyme Protein Phosphatase 2A (PP2A) and its regulatory B56 subunit and the role of PP2A-B56 in the regulation of Oxidative Resistance 1 (OXR1) function. The outcomes of this research plan will contribute to our understanding of the regulation of these proteins and expand potential therapeutic targets or points of intervention for B56-related pathologies.

PI_NAMEs: SMOLEN, KALI  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: 3-Dimensional;Binding;Biochemical;Biochemistry;Biological;Biological Process;Cell Line;Cell Survival;Cells;Cellular biology;collaborative environment;college;Communication;Data;Data Analyses;Development;developmental disease;Disease;DNA Damage;Environment;Epilepsy;Epitopes;Experimental Designs;Family;Family member;FRAP1 gene;Genes;Genome Stability;Glutamic Acid;Holoenzymes;human disease;Immunoprecipitation;Impaired cognition;In Vitro;inhibitor;innovation;insight;Intervention;knock-down;Knock-out;Knowledge;loss of function;Maintenance;Mass Spectrum Analysis;Mediating;Mentors;Metabolism;Muscle hypotonia;mutant;Mutate;Mutation;Nature;Norris Cotton Cancer Center;Outcomes Research;oxidation;Oxidative Phosphorylation;Oxidative Regulation;Oxidative Stress;Pathology;Peptides;Phenotype;Phosphopeptides;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphorylation Site;Phosphoserine;Phosphothreonine;Phosphotransferases;Physicians;Physiology;Post-Translational Protein Processing;PPP2R5D gene;Process;Proliferating;Protein Dephosphorylation;Protein Deregulation;Protein Isoforms;Protein phosphatase;Proteins;Proteomics;Proto-Oncogene Proteins c-akt;Regulation;Reporting;Research;Resistance;response;RNA Splicing;Role;scaffold;Scientist;Serine;Signal Pathway;Signal Transduction;Site;skills;Substrate Specificity;Techniques;Testing;Therapeutic Intervention;therapeutic target;Training;Translational Research;Up-Regulation;Variant

PROJECT_TITLE: Regulation and Function of PP2A-B56delta

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: Project Narrative Periodontal disease, a chronic inflammatory disease, affects about half of the US adult population and is linked to a number of serious systemic diseases. Neutrophils are immune cells that provide defense against pathogens, but they interact differently with some normally commensal (healthy) bacteria during disease, potentially allowing the bacteria to become harmful. This study will lead to a better understanding of pathogen-neutrophil relationships and will improve our ability to control periodontal disease and other chronic inflammatory diseases.

PI_NAMEs: BYNUM, KIANA  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Address;Adult;Affect;Bacteria;Biochemical;Biological Assay;career;Cells;Cellular biology;Chronic;chronic inflammatory disease;commensal bacteria;Communities;Complex;cooperative study;cytokine;Cytoplasmic Granules;Data;Defense Mechanisms;Development;Disease;Disease Progression;DNA;dysbiosis;Endosomes;Environment;experimental study;extracellular;Flow Cytometry;Goals;Growth;Human;Image;Image Analysis;Immobilization;Immune;Immune Evasion;Immune response;Immunology;improved;Incubated;Infection;Inflammation;Inflammatory;inflammatory milieu;Innate Immune System;innovation;Invaded;Knowledge;Laboratories;Link;Macrophage;Macrophage Activation;Mediating;member;Mentors;Microbe;microbial;Microbiology;microorganism;Microscopic;Microscopy;Natural Immunity;neutrophil;Neutrophil Activation;Oral;oral bacteria;oral biofilm;Outcome;pathogen;Pathology;Periodontal Diseases;Periodontitis;periodontopathogen;Phagocytes;Phagocytosis;Phagosomes;Phenotype;Play;Population;Porphyromonas gingivalis;Production;ratiometric;Reaction;Reactive Oxygen Species;recruit;Research;Research Personnel;Research Technics;Resistance;response;Role;Streptococcus gordonii;Systemic disease;Techniques;Tissues;Tooth Loss;Tooth structure;Training;training opportunity

PROJECT_TITLE: Cooperativity of Oral Microbes in Evading Neutrophil-Mediated Killing

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Cardiovascular;Hematology

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE For over 20 years this T32 training grant has supported pre- and post-doctoral trainees interested in hemostasis and thrombosis, areas with great clinical importance as heart attacks and strokes remain the number one cause of mortality in the western world. We are requesting renewal to maintain our rich history of mentoring in this space which is supported by an extra-ordinarily strong environment with an interactive and dedicated group of innovative and experienced faculty members. The renewed T32 will provide excellent research opportunities, while providing trainees with outstanding scientific development, mentoring, career development, and training in career growth to ensure that there is a next generation of scientists interested in the blood sciences.

PI_NAMEs: CAMIRE, RODNEY M (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TITLE: Training grant in hemostasis and thrombosis

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Diabetes;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Nutrition;Obesity;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Latinos have been disproportionally represented among COVID-19 cases and deaths in the United States. Latinos with diabetes are at particularly high risk given that diabetes is associated with poor outcomes including death. In addition, Latinos have been dramatically impacted by sequelae of the pandemic including a steep rise in household food insecurity, which leads to worsening glycemic control for those with diabetes. Effective multilevel interventions that can be remotely delivered are urgently needed for Latinos with diabetes to mitigate disparities due to COVID-19.

PI_NAMEs: ROSAS, LISA GOLDMAN (contact);TESTER, JUNE M

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: 2019-nCoV;Address;Adolescent;Adopted;Adult;Agriculture;arm;bean;Behavior;Behavior Therapy;behavioral outcome;California;Calories;Cessation of life;Classification;Clinic;Communities;community partners;Control Groups;Coping Skills;cost;County;COVID-19;COVID-19 complications;COVID-19 disparity;COVID-19 mortality;COVID-19 pandemic;COVID-19 stress;depressive symptoms;design;diabetes control;Diabetes Mellitus;Diet;dietary;Dietary Fiber;disparity reduction;Dissemination and Implementation;Distress;Dose;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness trial;Ethnic Population;experience;Fabaceae;Family member;Farm;Fiber;Food;food insecurity;Future;Gender;glycemic control;Glycosylated hemoglobin A;Goals;good diet;Government;Government Programs;Health Food;high risk;Home;Household;hybrid type 1 trial;Immigration;improved;Individual;Intake;Intervention;Interview;Latino;Latino Population;Leadership;Life;Life Style;lifestyle intervention;Location;Loneliness;Measures;Mediator;member;Methods;Neighborhood Health Center;neighborhood safety;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Obesity;Outcome;Overweight;pandemic disease;Participant;Patients;Persons;Phase;preservation;Primary Care;primary outcome;programs;Provider;psychosocial;psychosocial outcome;racial population;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;recruit;Recurrence;remote delivery;Risk Factors;Rotation;safety net;screening;Seasons;secondary outcome;social;Social Distance;Social support;Testing;Time;treatment as usual;United States;Vegetables;Waiting Lists

PROJECT_TITLE: The ADELANTE Trial: Testing a multi-level approach for improving household food insecurity and glycemic control among Latinos with diabetes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-H(58)R]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Neurosciences;Rare Diseases

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Narrative Succinyl-CoA Synthetase (SCS) is a component of the Kreb Cycle, which is a central feature of energy metabolism (the metabolic conversion of the building blocks of food into a chemical energy source for the cell). Deficiency of SCS is a form of mitochondrial disease that cause brain and muscle dysfunction that is associated with the reduction of mitochondrial DNA content in the cell. This project establishes a model of SCS deficiency in adult mice that will facilitate the exploration of SCS’s role in brain as well as fundamental pathogenic mechanisms resulting from SCS deficiency.

PI_NAMEs: GRAHAM, BRETT HARRISON (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: ACTL6B gene;Acylation;Adolescent;Adult;Alleles;Animals;ATAC-seq;Behavioral;Behavioral Assay;Binding;Biological Assay;Brain;Cardiomyopathies;cell cortex;Cell Nucleus;cell type;Cells;Chemicals;Chromatin;Citric Acid Cycle;Cognitive;Cognitive deficits;cohort;Complex;conditional knockout;Control Animal;Data;Data Set;Defect;design;Development;Dimensions;Disease;Dissection;efficacious treatment;Electron Transport;Embryo;Encephalopathies;Energy Metabolism;Energy-Generating Resources;enzyme activity;Enzymes;epigenomics;Exhibits;Food;Functional disorder;Future;Gene Expression Profile;Genetic;Hippocampus;in vivo;innovation;insight;Intellectual functioning disability;Investigation;Knock-out;Learning;LoxP-flanked allele;Lysine;Measures;Memory;Metabolic;metabolic phenotype;metabolomics;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;mitochondrial dysfunction;Mitochondrial Encephalomyopathies;Modeling;Molecular;Motor;multiple omics;Mus;Muscle;mutant;Mutant Strains Mice;Myopathy;Nervous System Disorder;Neurologic Dysfunctions;Neurons;neuropathology;novel therapeutic intervention;Nuclear;Nuclear RNA;Organ;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Pattern;Phenotype;Physiological;Ploidies;postnatal;Pre-Clinical Model;prenatal;Prosencephalon;Proteins;Proteomics;Quantitative Reverse Transcriptase PCR;Role;Sampling;screening;Screening Result;Sensory;Succinate-CoA Ligases;Therapeutic;Tissue-Specific Gene Expression;Tissues;transcriptome sequencing;transcriptomics;Transgenes;Tricarboxylic Acids;Validation

PROJECT_TITLE: Determination of pathogenetic mechanisms in cortex-specific Sucla2 deficiency as a model for mitochondrial encephalopathy

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Genetics;Human Genome;Kidney Disease;Regenerative Medicine

PHR: Narrative A single episode of acute kidney injury (AKI) enhances the risk for chronic disease and long term loss of kidney function. Molecular and cellular studies identified a pro-inflammatory cell type resulting from failed renal tubule repair associated with progressive kidney disease. Blocking this cell's inflammatory properties, and ultimately eliminating the cell entirely, is projected to improve outcomes following AKI.

PI_NAMEs: HUMPHREYS, BENJAMIN D. (contact);KIM, JUNHYONG ;MCMAHON, ANDREW P.

PROJECT_TERMS: 3-Dimensional;Ablation;Acute;Acute Renal Failure with Renal Papillary Necrosis;Adopted;adverse outcome;aged;Atlases;Attenuated;Automobile Driving;Bioinformatics;California;Candidate Disease Gene;Cell Nucleus;cell type;Cells;Chromatin;Chronic Disease;Chronic Kidney Failure;Communities;Data;data mining;Data Set;Databases;Development;Diagnosis;Epigenetic Process;epigenome;Epithelial Cells;epithelial injury;Excision;experience;Female;Fibrosis;Gene Deletion;Gene Expression;Genes;Genetic;genetic approach;Genetic Transcription;high risk;Hospitalization;Human;Immunohistochemistry;Impairment;improved;improved outcome;In Situ Hybridization;Inflammation;Inflammatory;injured;Injury;Injury to Kidney;Intervention;Kidney;kidney biopsy;Kidney Diseases;kidney repair;Knock-out;Knowledge;Laboratories;Logic;male;MAP4K4 gene;Maps;Medicare;member;men;Modeling;Modification;Molecular;mouse model;multimodal data;multimodality;multiple omics;Mus;Nephrons;NF-kappa B;novel;novel strategies;novel therapeutic intervention;Nuclear;Nuclear RNA;Online Systems;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Persons;Population;Predisposition;prevent;Probability;Process;profibrotic cytokine;Profibrotic signal;Property;Recovery;Recurrence;Renal function;Renal tubule structure;repair strategy;repaired;Research;Resources;response;response to injury;Risk;Role;Route;Sampling;sex;Sex Differences;Signal Transduction;single cell analysis;single molecule;single nucleus RNA-sequencing;single-cell RNA sequencing;Surveys;Technology;Testing;therapeutic development;Therapeutic Intervention;therapeutic target;Time;TNF Receptor-Associated Factors;transcriptome;transcriptome sequencing;transcriptomics;Transgenic Mice;Tubular formation;Universities;Visualization software;Washington

PROJECT_TITLE: Single-cell analysis to promote kidney repair


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Dystonia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Craniofacial dystonia results in substantial disability in affected individuals. Although these disorders show evidence of being inherited, the genetics have been difficult to understand. We propose to use a combination of DNA analysis, fMRI brain imaging and cell biology to help identify the genetic risk to the development of craniofacial dystonia.

PI_NAMEs: SHARMA, NUTAN  (contact)

PROGRAM_OFFICER_NAME: CHOU, ALICIA YESIU

PROJECT_TERMS: Address;Affect;Agonist;antagonist;Automobile Driving;Binding;Biological Assay;Blepharospasm;Body part;Brain;brain cell;Brain imaging;Brain Mapping;Cell Line;Cell model;Cellular biology;clinical phenotype;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;Complex;craniofacial;craniofacial development;craniofacial disorder;Data;Dependence;Development;disability;Disease;disorder risk;DNA analysis;Dystonia;Engineering;Etiology;exome sequencing;Eye;Family;fluorescence lifetime imaging;Focal Dystonias;Functional Magnetic Resonance Imaging;gene discovery;gene network;Genetic;genetic analysis;Genetic Risk;Genetic study;genetic variant;Genetic Variation;Genome;genome editing;genome wide association study;genome-wide;Heritability;Human;Image;Individual;induced pluripotent stem cell;Inherited;innovation;insight;interest;Investigation;Jaw;Link;Meige Syndrome;Methods;microscopic imaging;Movement;Muscle;Mutation;National Institute of Dental and Craniofacial Research;nerve stem cell;neural;neuroimaging;Neurons;Nuclear Envelope;Optics;Outcome Study;Pathogenicity;Patients;Pattern;Phenotype;polygenic risk score;Posture;protein complex;protein protein interaction;Proteins;Public Health;Qualifying;Quality of life;Rare Diseases;reconstruction;Records;Research;Research Personnel;response;Rest;Risk;Risk Factors;segregation;Spastic Dysphonias;stem cell model;superresolution microscopy;Syndrome;Testing;tool;trait;Variant;Vision

PROJECT_TITLE: Genetic Variants in Craniofacial Dystonias

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Genetics;Human Genome;Immunization;Immunotherapy;Pancreatic Cancer;Rare Diseases;Vaccine Related

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Pancreatic cancer represents a so-called immunogenically “cold” tumor that is not sensitive to immune checkpoint inhibitors due to an “impaired” tumor microenvironment with multiple “defects”. In prior studies, we found that the immunogenically “cold' tumor of pancreatic cancer was converted to an immunogenically “hot” tumor by immunotherapeutic strategies including vaccine therapy and the combination of vaccine therapy and immune checkpoint inhibitor. This project will study the mechanisms of targeting reprogrammed tumor microenvironment via either T cell agonist or granulocyte antagonist to enhance the effector T cell function directly or through counteracting the immunosuppressive factors in the tumor microenvironment.

PI_NAMEs: BURNS, WILLIAM REECE;JAFFEE, ELIZABETH M. (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Aftercare;Agonist;Annexins;antagonist;anti-PD-1;anti-PD1 antibodies;anti-PD1 therapy;Antibodies;arm;Award;Biopsy;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Clinical Trials;Clonal Expansion;Clone Cells;Combination immunotherapy;Combined Vaccines;Complex;Data;Data Analyses;Defect;density;effector T cell;exhaustion;Funding;genetically modified cells;Goals;granulocyte;Granzyme;GVAX Cancer Vaccine;IL8 gene;Immune;immune checkpoint;Immune checkpoint inhibitor;immunogenic;Immunohistochemistry;Immunologics;Immunotherapeutic agent;Immunotherapy;Impairment;Implant;Infiltration;ITGAM gene;Lymphoid;Malignant neoplasm of pancreas;mesothelin;Modeling;Modification;mouse model;Myeloid Cells;Neoadjuvant Therapy;neoantigens;neoplastic cell;neutrophil;Nivolumab;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;Pathologic;Patients;PD-1/PD-L1;peptide based vaccine;Phenotype;preclinical study;prevent;programmed cell death protein 1;randomized, clinical trials;rational design;Regulatory T-Lymphocyte;Resectable;Resected;Resistance;resistance mechanism;response;Serum;Signal Transduction;single-cell RNA sequencing;Specimen;T cell infiltration;T cell receptor repertoire sequencing;T-Lymphocyte;Testing;Therapeutic;Therapeutic Intervention;trafficking;tumor;Tumor Antigens;tumor microenvironment;tumor-immune system interactions;Tumor-infiltrating immune cells;Vaccine Therapy;Vaccines

PROJECT_TITLE: Targeting the Immunosuppressive Tumor Microenvironment of Pancreatic Cancer with a Neoadjuvant Platform Clinical Trial

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Genetics;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: Project Narrative/ Public Health Relevance Statement This proposal aims to determine the molecular and cellular mechanisms of trabecular formation and compaction, identify the etiology and treatments for left ventricle non- compaction cardiomyopathy.

PI_NAMEs: WU, MINGFU  (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: Affect;Area;Biological Assay;Cardiac;Cardiac Myocytes;cardiogenesis;Cardiomyopathies;Cardiovascular Diseases;Cardiovascular system;cell behavior;Cell division;Cell Lineage;Cells;clinically significant;Contractile Proteins;Coronary;Coronary Circulation;Cytoskeletal Proteins;Data;Defect;Deposition;Developed Countries;Disease;Echocardiography;Embryo;Embryonic Heart;Endocytosis;Etiology;Fibronectins;FN1 gene;Gene Proteins;Genes;Genetic;Genetic Models;Growth;Heart;Heart failure;Human;in vivo;Integrin alpha5beta1;Integrin alpha6;Integrin alpha6beta1;Integrins;Invaded;ITGA5 gene;Knock-out;Left ventricular non-compaction;Left ventricular structure;Ligands;Measures;Mediating;Membrane;Microscope;migration;Modeling;Molecular;Morbidity - disease rate;Morphogenesis;mortality;mouse model;Muscle Cells;Mutant Strains Mice;Mutation;Myocardium;Non-compaction cardiomyopathy;notch protein;Notch Signaling Pathway;Online Mendelian Inheritance In Man;overexpression;Patients;Pharmaceutical Preparations;Pharmacotherapy;postnatal;Prevalence;prevent;Proteins;public health relevance;Recombinant adeno-associated virus (rAAV);Reporting;Role;Sarcomeres;Signal Transduction;Signaling Protein;Source;Structure;Surface;Symptoms;System;Testing;Thick;Time;Tissues;tool;Traction Force Microscopy;ultra high resolution;Ventricular

PROJECT_TITLE: Signaling by beta 1 integrins regulates ventricular wall morphogenesis and compaction

STUDY_SECTION: CCHF

STUDY_SECTION_NAME: Cardiac Contractility, Hypertrophy, and Failure Study Section[CCHF]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: TROY

ORG_NAME: RENSSELAER POLYTECHNIC INSTITUTE

PHR: Project Narrative The heart is left-right asymmetric with its apex pointing towards the left. Deviation from such an asymmetry leads to severe congenital malformations and has significant clinical implications. Here we propose to study the role of cell handedness in the establishment of left-right asymmetry during cardiac development.

PI_NAMEs: WAN, LEO Q. (contact)

PROJECT_TERMS: 3-Dimensional;Actins;alpha Actinin;Animal Genetics;Animal Model;Anterior;Apical;Apoptosis;Biochemical;Biological Assay;biomechanical model;Biomechanics;biophysical analysis;Biophysical Process;Biophysics;Cadherins;Cardiac;cardiogenesis;Cell Differentiation process;Cells;Chemicals;Chick;Clinical;Congenital Abnormality;congenital heart abnormality;crosslink;Crosslinker;cytokine;Cytoskeleton;Defect;Development;Dextrocardia;directional cell;Double Outlet Right Ventricle;Drosophila genus;Embryo;embryo culture;Embryonic Heart;Event;Exhibits;experimental study;fascin;Fetal Death;Genetic;Genitalia;Handedness;Heart;high throughput screening;Hindgut;Human;Hydrogels;In Vitro;in vitro Model;Infant;inhibitor;interest;kinase inhibitor;Left;Libraries;Literature;Live Birth;live cell imaging;Measures;mechanical force;Microfabrication;Molecular;Morphogenesis;Morphology;mouse model;Myocardium;Myosin Type II;Nature;Nodal;novel;Organ;Outcome;Pattern;Pharmaceutical Preparations;Phenotype;Phosphotransferases;Population;Property;Protein Isoforms;Protein Kinase C;Research;Role;Rotation;Scaffolding Protein;screening;septal defect;Shapes;Side;Signal Pathway;Signal Transduction;small molecule;small molecule inhibitor;Structure;Surface;System;Technology;Teratogens;Tissues;tool;Traction Force Microscopy;Translating;Tube;Vertebrates;Visceral;Work

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]