NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE B-cell acute lymphoblastic leukemia (B-ALL) remains a leading cause of childhood morbidity and mortality, and a full understanding of how this disease develops is lacking. In this study, we will integrate genetic epidemiology with innovative functional genomic approaches to determine the mechanisms through which germline genetic risk variants associated with B-ALL can impact B cell development and leukemogenic processes. Our unique approach will reveal novel insights into the etiology of B-ALL and may inform targeted therapeutic and preventive strategies.

PI_NAMEs: DE SMITH, ADAM ;SANKARAN, VIJAY GANESH (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Acute Lymphocytic Leukemia;Alleles;B cell differentiation;B-Cell Acute Lymphoblastic Leukemia;B-Cell Development;B-Lymphocytes;base editing;Bone Marrow;Cancer Etiology;causal variant;Cells;Child;Childhood;Childhood Acute Lymphocytic Leukemia;Childhood Leukemia;Childhood Precursor B Lymphoblastic Leukemia;Chromatin;collaborative approach;Coupling;Data;Data Set;Development;differentiation in vitro;Disease;disorder risk;disparity reduction;Ensure;epigenomics;Ethnic Origin;Etiology;Face;Flow Cytometry;functional genomics;Future;GATA3 gene;Generations;Genes;Genetic;genetic epidemiology;Genetic Predisposition to Disease;Genetic Risk;genome editing;genome wide association study;Genomic approach;Genomics;Genotype;Germ Lines;Goals;Grant;Hematopoiesis;Hematopoietic stem cells;high risk;Hispanic;Human;human data;Individual;Inferior;Inherited;innovation;insight;interest;Intervention;Joints;Knowledge;Latino;leukemia;leukemogenesis;Malignant Childhood Neoplasm;Maps;Measurement;Methods;Morbidity - disease rate;mortality;Multiomic Data;new therapeutic target;Not Hispanic or Latino;novel;Patient-Focused Outcomes;Patients;Phenotype;Positioning Attribute;Predisposition;Prevention;Prevention strategy;Preventive;Process;progenitor;Recovery;Regulatory Element;Resolution;Risk;risk variant;Sampling;single cell ATAC-seq;single-cell RNA sequencing;Survivors;System;targeted treatment;V(D)J Recombination;Variant

PROJECT_TITLE: Variant to Function Mapping of B-ALL Risk Loci

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Newark

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project narrative Transcription factor (TF) networks access, decode and implement genomic information to provide a differentiated cell with its identity as well as the plasticity to respond to incoming signals (such as environmental and developmental cues). In some instances, incoming signals can destabilize TF network function and force the cell into a dysfunctional state known as senescence, which promotes disease across multiple tissues. In this proposal, we will harness the power of time-resolved multiomic profiling to define and manipulate the TF networks of cells transitioning through senescence states linked to disease as a novel approach to restore cell function and to develop diagnostic/prognostic tools for disease monitoring, potentially paving the way for a new era of epigenomic medicine.

PI_NAMEs: MARTINEZ ZAMUDIO, RICARDO IVAN (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Aging;aging process;Cell Death;Cell Differentiation process;Cell Physiology;Cell Separation;Cell Therapy;cell type;Cells;Chondrocytes;Cues;cytokine;Data;Data Set;Degenerative polyarthritis;design;Development;Diagnostic;Disease;Environment;epigenomics;Fibrosis;functional restoration;gene regulatory network;Generations;genetic manipulation;Genetic Transcription;genome editing;Genomics;Goals;Hepatic Stellate Cell;High-Throughput Nucleotide Sequencing;Homeostasis;Human;human data;Link;Maintenance;Malignant Neoplasms;Mediating;Medicine;Methods;Modeling;Monitor;multiple omics;network models;novel strategies;Outcome;Pathologic Processes;pharmacologic;prognostic assays;prognostic tool;programs;Research;Resolution;response;reverse genetics;Sampling;senescence;senescent cell;Series;Signal Transduction;Structure;Therapeutic;Time;Tissues;transcription factor;Transitional Cell;Vision

PROJECT_TITLE: Transcription Factor Network-Mediated Modulation of Transitional Senescence States

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-D (55)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dietary Supplements;Disability Research;Genetics;Human Genome;Neurosciences;Stroke

ORG_CITY: NEW ORLEANS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: Project Narrative This project will open avenues to translate novel intervention strategies using IND precursors and ELVs to protect the ischemic stroke penumbra. The results will move the field of stroke research and other neurological diseases forward and pave the way to a therapeutic neuroprotection paradigm shift away from just blocking neuroinflammation, as is often the case. Ultimately, the new knowledge will improve the quality of life of young and older individuals of both genders after ischemic stroke, which remains among the most significant challenges to public health.

PI_NAMEs: BAZAN, NICOLAS G. (contact);BELAYEV, LUDMILA S.

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: aged;Anabolism;Anti-Inflammatory Agents;Astrocytes;ATAC-seq;Behavior;Behavioral;Biological;Blood - brain barrier anatomy;blood-brain barrier permeabilization;Brain;Brain Edema;Brain Ischemia;Cell Nucleus;Cell Survival;Cells;Central Nervous System;cerebrovascular;Data;differential expression;Dose;Elderly;Electrophoresis;Enzymes;epigenomics;Event;Extravasation;Failure;Fatty Acids;Frequencies;Gender;Gene Cluster;Gene Expression;Genes;Genetic Transcription;Goals;Hemorrhage;Histologic;Hour;improved;Infarction;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;Intervention;Ischemia;Ischemic Penumbra;Ischemic Stroke;Knowledge;Lead;Lesion;lipid mediator;lipidomics;Long term disability;Macrophage;Magnetic Resonance Imaging;Mediating;Membrane;Microglia;Middle Cerebral Artery Occlusion;Modeling;Molecular;monocyte;multiple omics;Nervous System Disorder;neurobehavioral;neurobehavioral test;neuroinflammation;Neurons;neuroprotection;neurovascular unit;Nonesterified Fatty Acids;novel;novel therapeutics;Older Population;Omega-3 Fatty Acids;Pathway interactions;Phase;Phenotype;Phospholipids;prevent;Process;Protein Analysis;Proteins;Public Health;Quality of life;Randomized;Rattus;Recovery;repaired;Reperfusion Injury;Research;response;Role;Signal Transduction;single cell genomics;Small Nuclear RNA;Stroke;stroke model;Technology;Testing;Therapeutic;therapeutically effective;Time;Transcript;transcriptomics;Translating;Up-Regulation;Very Long Chain Fatty Acid

PROJECT_TITLE: Neuroprotective lipid mediators target penumbra in experimental ischemic stroke

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Stroke

ORG_CITY: CHICAGO

ORG_DEPT: NEUROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: The risk and burden of stroke are disparately experienced by Black, Latino/a/x, and low-income people. We seek to develop a simple, personalized intervention that bridges the community and health system to improve post-stroke outcomes among populations that experience health disparities. Through meaningful community engagement, we will achieve clinical trial readiness, enhance community partnerships, invest in local public health capacity, and contribute to thriving communities to promote health equity.

PI_NAMEs: SKOLARUS, LESLI ELIZABETH (contact)

PROGRAM_OFFICER_NAME: SANKAR, CHERYSE A

PROJECT_TERMS: Academy;Acceleration;acceptability and feasibility;Address;Adherence;Advocate;Behavior Therapy;Black race;Caregivers;caregiving;Caring;Chicago;clinical trial readiness;Collaborations;Communities;community academic partnership;community advisory board;community college;community engagement;community partnership;Data Scientist;Disabled Persons;Disparity;Disparity population;Economically Deprived Population;Equipment and supply inventories;Equity;ethnic minority population;experience;Food;Goals;Health;Health behavior;health disparity;health equity;health equity promotion;Health equity research;Health system;high school;Housing;Illinois;improved;Inequity;Intervention;Interview;Investments;Knowledge;Latina;Latino;Latinx;Lived experience;Low Income Population;Maps;Medical;medical appointment;medication nonadherence;member;Michigan;Minority;Minority Groups;Modeling;Outcome;Participant;Patients;personalized intervention;Pharmaceutical Preparations;Population;post stroke;Productivity;programs;Public Health;racial minority population;Recommendation;Regimen;Rehabilitation therapy;Resources;Risk;Risk Reduction;routine care;Services;Side;simulation;social;social health determinants;socioeconomic disadvantage;Stroke;stroke outcome;Stroke prevention;stroke risk;stroke survivor;Structure;student training;survivorship;System;Training;Transportation;university student;Visit;Work;Workload;Youth

PROJECT_TITLE: Advancing Community Connections and Calculating Risk to Optimize Stroke Survivorship (ACROSS)

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-A (07)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: AMES

ORG_DEPT: GENETICS

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: Elucidating Context-Specific FERONIA Receptor Kinase Signaling Project Narrative The proposed studies will provide unprecedent new insights into how FER receptor kinase achieves signaling specificity. Receptor kinases signaling pathways play critical roles in diverse cellular processes and deregulation of the pathways leads to serious human diseases such as cancer. Understanding the pathway specificity has been a major area of study in developing effective therapies. Better understanding cell signaling specificity of FER receptor kinase can help shed light on receptor kinase signaling pathways related to human health.

PI_NAMEs: GUO, HONGQING  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Abscisic Acid;Acids;Affect;Arabidopsis;Area;biological adaptation to stress;Biological Process;Cell Physiology;cell type;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;CRISPR/Cas technology;Data;Development;Developmental Biology;effective therapy;Family;Fertility;Gene Expression;gene regulatory network;Genes;Genetic;genetic manipulation;Genetic Models;Genetic Transcription;Genomics;Germination;Goals;Health;Human;human disease;Immunity;insight;Knock-out;loss of function;Malignant Neoplasms;Mediating;multiple omics;mutant;Mutation;Pathway Analysis;Pathway interactions;Pattern;Phosphorylation;Phosphotransferases;plant growth/development;Plant Model;Plants;Play;receptor;Research;response;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Sodium Chloride;Specificity;Stress;System;Testing;Tissues;transcription factor;transcriptome

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Clinical Research;Hematology;Infectious Diseases;Pediatric;Precision Medicine;Sepsis

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Translational approaches to unravel organ-specific microvascular endothelial responses in sepsis. NARRATIVE: My laboratory is focused on understanding how injury to blood vessel cells contributes to organ damage in children with sepsis –a life-threatening condition caused by an infection. By detailed study of free-floating blood vessel cells and by treating miniature blood vessel organs in petri dishes with plasma collected from children with sepsis, we seek to identify genes that lead to organ damage. Our studies may lead to the discovery of medicines that can help recover from organ damage and help save the lives of very sick children with sepsis.

PI_NAMEs: ATREYA, MIHIR R (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Address;advanced disease;Atlases;Basic Science;Biological;Biological Markers;Blood Vessels;Candidate Disease Gene;Caring;Cells;Child;Clinical;Coagulation Process;Collaborations;Coupled;CRISPR/Cas technology;Critical Illness;Data Set;Development;disease model;Endothelial Cells;endothelial dysfunction;Endothelium;Evolution;Failure;Functional disorder;Funding;Future;gene editing technology;Gene Expression Profiling;Genes;Heterogeneity;Homeostasis;Human;human induced pluripotent stem cells;Hypoxia;Immune response;improved;improved outcome;In Vitro;Infection;Inflammation;Injury;Institution;Knowledge;Laboratories;Laboratory Research;Life;Medicine;Modeling;mortality;National Institute of General Medical Sciences;Nature;Organ;Organ Specificity;Organoids;Outcome;patient subsets;Patients;pediatric sepsis;Pharmaceutical Preparations;Plasma;Pre-Clinical Model;Precision therapeutics;programs;Publishing;Recovery;Research;Resolution;Resource Sharing;response;risk stratification;Sampling;Scientist;Sepsis;Septic Shock;systemic inflammatory response;targeted treatment;Technical Expertise;Testing;Thrombosis;tissue injury;Tissues;transcriptomics;translational approach;Translations;Vascular Endothelium;Whole Blood

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


ORG_CITY: AUSTIN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: PROJECT NARRATIVE Polyelectrolyte complex micelles (PCMs) are attractive as a nucleic acid delivery system, but the design parameters that control key aspects of delivery are not yet defined, preventing PCM technology from being easily adapted for new targets. The goal of this proposal, and of our research lab, is to develop quantitative design rules that govern nucleic acid PCM assembly, physical properties, delivery capabilities, and dynamic behavior. Developing a comprehensive and quantitative understanding of the parameters that control nucleic acid PCM assembly, distribution, and delivery will build a foundation for a new class of PCMs with predictive properties that can be tailored for specific treatments.

PI_NAMEs: MARRAS, ALEXANDER EDISON (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Area;Automobile Driving;Behavior;Charge;Chemicals;Chemistry;Complex;Computing Methodologies;Databases;density;design;Electron Microscopy;fluorescence imaging;Foundations;Goals;Hydration status;hydrophilicity;Kinetics;Laws;Micelles;microscopic imaging;Mission;nanoparticle;National Institute of General Medical Sciences;Nature;nucleic acid delivery;nucleic acid structure;Nucleic Acids;physical property;Physiological;polyanion;polycation;Polymers;prevent;Process;Property;Research;Roentgen Rays;self assembly;Structure;System;Techniques;Technology;uptake;Work

PROJECT_TITLE: Expanding the design space of polyelectrolyte complex micelles

STUDY_SECTION: MRAE

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - E Study Section[MRAE]


ORG_CITY: CHAMPAIGN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: Narrative Despite being traditionally studied in simplified experimental systems, human pathogens experience complex environmental dynamics during infection. Here, I propose to use microfluidics to study how shear flow impacts H2O2 stress responses and surface adhesion of the human pathogen Pseudomonas aeruginosa. By providing mechanistic insight into bacterial processes in dynamic host-relevant environments, our work will lay a solid foundation for innovative advances in the treatment of bacterial infections.

PI_NAMEs: SANFILIPPO, JOSEPH  (contact)

PROJECT_TERMS: Adhesions;Bacteria;bacterial community;Bacterial Infections;biological adaptation to stress;Biology;Complex;Dose;Environment;experience;fluid flow;Foundations;Funding;human pathogen;Hydrogen Peroxide;Infection;innovation;insight;Microbiology;microfluidic technology;Microfluidics;Modeling;Molecular Biology;Pilum;Process;Pseudomonas aeruginosa;Research;Solid;Surface;System;Work

PROJECT_TITLE: Bacterial stress responses and surface adhesion in shear flow


ORG_CITY: ITHACA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative In this proposal, we aim to uncover the evolutionary processes and regulatory mechanisms by which Y chromosomes generate diversity within the sexes. To accomplish this, we will leverage the unique power of the Poecilia parae system, in which male morphs (that differ in size, color, and behavior) are inherited perfectly through highly diverged Y chromosomes. This work has direct implications on our understanding of how gene regulation and developmental processes encoded by Y chromosomes generate diversity within the sexes of the same population.

PI_NAMEs: SANDKAM, BENJAMIN ALEXANDER (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: autosome;Behavior;Biology;Breeding;Characteristics;Color;Complex;Controlled Study;Development;Developmental Process;Drosophila genus;Evolution;Fishes;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;Genome;genome resource;Haplotypes;Heterochromatin;Inherited;male;Mediating;Morphology;Nature;Phenotype;Poecilia;Population;Process;Research;Rest;Role;sex;Sex Chromosomes;Structure;System;Work;Y Chromosome

PROJECT_TITLE: The role of Y chromosomes in generating and maintaining intrasexual diversity

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative Intrinsic molecular circadian rhythms in adipose tissue control metabolic processes that are dysregulated in people with specific types of obesity, however, these same functions are highly responsive to intermittent food intake over the day. As such, these studies will determine the relative contribution of adipose tissue intrinsic circadian rhythms and intermittent meal delivery on molecular and systemic adipose tissue function in humans in the context of obesity. By better understanding the relationship between these processes we can develop new treatments for people with obesity and those with regular disruptions in circadian rhythms such as shift workers, who have increased risk of obesity and Type 2 diabetes.

PI_NAMEs: LYTLE, KELLI ANNE (contact)

PROGRAM_OFFICER_NAME: SILVA, CORINNE M

PROJECT_TERMS: Address;Adipocytes;Adipose tissue;ARNTL gene;Biopsy;cell type;Cells;circadian;Circadian Dysregulation;circadian pacemaker;circadian regulation;Circadian Rhythms;Clinic;clinical translation;Data;Development;Disease;Eating;environmental enrichment for laboratory animals;Enzymes;Exhibits;Fasting;Fatty acid glycerol esters;fatty acid metabolism;Fatty Acids;Feedback;feeding;Food;Functional disorder;Gene Expression;Genes;Genomics;Goals;hormonal signals;Hour;Human;in vivo;Intake;knowledge translation;Lipolysis;Literature;Liver;Measures;Mentorship;Metabolic;Metabolic Control;Metabolic Diseases;Metabolism;Molecular;molecular clock;mouse model;Mus;Muscle;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;novel;Nutrient;Obesity;obesity risk;Output;Pancreas;Pathogenesis;Pathology;Pathway interactions;Pattern;Periodicity;Persons;Process;programs;Proteins;Regulation;Research;Research Activity;response;Risk;Rodent Model;Role;Secondary to;shift work;Signal Transduction;skills;subcutaneous;System;Testing;Thinness;Tissue Sample;Tissues;Training;Transcript;transcription factor;Weight;Work

PROJECT_TITLE: Circadian regulation of molecular and systemic adipose tissue function in humans

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE In this proposal, we will characterize the noncanonical role(s) of the BH3-only protein, Bim, in the regulation of endolysosomal trafficking, permeabilization, and exocytosis during heat shock-induced cell death.

PI_NAMEs: BRATTON, SHAWN B (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Amphetamines;Anesthetics;Anhidrosis;Anti-Cholinergics;Apoptosis;Apoptotic;BCL2 gene;BH3 Domain;BID protein;Binding;Biology;Body System;Body Temperature;CASP2 gene;Cathepsin L;Cathepsins;Cell Cycle;Cell Death;Cell Death Induction;Cell Death Signaling Process;Cell Membrane Permeability;Cell Nucleus;Cells;climate change;Clinic;Complex;Cytoplasm;Data;Disease;Diuretics;Dynein ATPase;dynein light chain;Exertion;Exhibits;Exocytosis;Exposure to;Extracellular Space;Failure;Family member;Goals;Heat Stroke;Heat-Shock Response;High temperature of physical object;Histone H3.3;Hyperthermia;Hypohidrosis;in vivo;inhibitor;insight;Knock-out;Lipids;Local Hyperthermia;Lysosomes;Malignant Neoplasms;Mediating;Modeling;Motor;mouse model;mutant;mutant mouse model;Mutant Strains Mice;Mutation;novel;Nuclear;Organ failure;Pathway interactions;Patients;Peripheral;Permeability;Pharmaceutical Preparations;Physical activity;Physiologic Thermoregulation;Play;Positioning Attribute;Predisposition;Process;Proteins;Regulation;Reporting;Resistance;response;Risk;Role;stefin;Temperature;Tissues;trafficking;transcription factor;tumor

PROJECT_TITLE: Noncanonical roles of Bim in heat shock-induced cell death

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: STANFORD

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Engineering precise cellular recognition between T cells and cancer cells holds promise for advancing public health. Focusing on engineering antigen density-based recognition between T cells and cancer cells, we anticipate signiﬁcant advances for solid tumors treatments with potential implications for infectious diseases and autoimmunity. This aligns with the NIH NIGMS’s mission of supporting research that contributes to our understanding fundamental cellular principles.

PI_NAMEs: HERNANDEZ-LOPEZ, ROGELIO ANTONIO (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Address;Affect;Antigens;Architecture;Autoimmunity;Behavior;cancer cell;cell behavior;Cell Communication;Cells;Cellular biology;cellular engineering;chemokine;Communicable Diseases;Communication;comparative;density;Discrimination;Engineered Gene;engineered T cells;Engineering;Foundations;Gene Expression;Genome;Immune response;improved;Infiltration;Laboratories;Methods;Mission;Molecular;molecular recognition;National Institute of General Medical Sciences;novel;Property;Public Health;Research;Research Support;Role;sensor;Signal Transduction;Solid Neoplasm;Specificity;spheroids;synergism;synthetic biology;System;T-Lymphocyte;Therapeutic;Tissue Engineering;Tissues;Titrations;trafficking;tumor;tumor heterogeneity;United States National Institutes of Health;Variant

PROJECT_TITLE: Antigen Density Sensors for Cell Engineering

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-F (55)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Genetic Testing;Genetics;Health Services;Human Genome;Pediatric;Pregnancy;Prevention;Social Determinants of Health

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: PROJECT NARRATIVE This study will compare a novel, mobile-friendly, just-in-time consent model to current ways of offering prenatal genetic screening. The clinical trial will recruit at three diverse sites that serve a large pregnant population from historically underserved communities. The goal is to build an ethical and realistic approach to helping pregnant patients make informed decisions about prenatal genetic screening.

PI_NAMEs: ALLYSE, MEGAN A. (contact);MICHIE, MARSHA MABRY

PROGRAM_OFFICER_NAME: JOSE, SHEETHAL

PROJECT_TERMS: abortion;Address;Amniotic Fluid;Aneuploidy;Anxiety;autosome;California;Caring;cell free DNA;Characteristics;Child Rearing;Clinic;Clinical;clinical encounter;clinical research site;Clinical Trials;community consultation;community engaged research;Consent;Counseling;Data;Decision Making;design;Diagnostic tests;disability;Distress;Education;Elements;Ethical Analysis;Ethics;experience;Family;fetal;Florida;follow-up;Friends;Future;Genetic;Genetic Diseases;Genetic Screening;Geography;Goals;Health Personnel;Health system;high risk;Hybrids;implementation study;Individual;Informed Consent;Intervention;Interview;Knowledge;Literature;Malignant Neoplasms;maternal serum;member;Microarray Analysis;Minority;Modeling;Morals;Mosaicism;Nature;North Carolina;novel;Other Genetics;Outcome;patient oriented;Patients;Persons;pilot test;Placenta;Population;Population Heterogeneity;post intervention;Pregnancy;pregnant;prenatal;Prenatal care;prenatal testing;Probability;Procedures;Provider;Psyche structure;Psychological Stress;Questionnaires;Recommendation;recruit;Research;Resource-limited setting;Resources;routine screening;satisfaction;scale up;screening;shared decision making;Site;Social support;standard of care;statistics;Structure;Technology;Test Result;Testing;Time;trial design;underserved community;Weight

PROJECT_TITLE: Supporting Just-in-Time Consent for Prenatal Screening in Diverse Populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SEIR-P (80)]


ADMINISTERING_IC: HD

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Human Genome;Infertility;Maternal Health;Pediatric;Pregnancy;Women's Health Research

ORG_CITY: College Station

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

PHR: NARRATIVE Paternal epigenetic contributions, or non-genetic changes to DNA, are delivered to the embryo from mammalian sperm, however the mechanisms through which they regulate embryo development, placentation, and maintenance of pregnancy are largely unknown. We propose the use of sperm from bulls of high and low fertility to investigate the role of the paternal epigenome in abnormal embryo development and pregnancy loss.

PI_NAMEs: LUENSE, LACEY J (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Affect;Animal Model;Binding;blastocyst;Cattle;Chromatin;Clinical;Clinical Management;Data;Development;Diagnosis;DNA;DNA Structure;Embryo;Embryonic Development;Epigenetic Process;epigenome;epigenomics;Ethics;Exhibits;experimental study;Fertility;Fertilization in Vitro;Foundations;Genes;Genetic Transcription;Genome;Genomics;healthy pregnancy;Histones;Human;Infertility;insight;Intracytoplasmic Sperm Injections;Investigation;Lead;Learning;Link;Male Infertility;Maps;men;Modeling;Molecular;Mus;Mutation;non-genetic;Nuclear Structure;Nucleosomes;Patients;Placentation;Play;Positioning Attribute;Post-Translational Protein Processing;potential biomarker;Pre-implantation Embryo Development;Pregnancy;Pregnancy loss;Pregnancy Maintenance;Pregnancy Rate;pregnant;premature;promoter;Protamines;Proxy;Recurrence;Regulation;reproductive;Research;Role;sperm cell;Spontaneous abortion;success;Techniques;Testing;United States;Unwanted pregnancy;Uterus;Woman

PROJECT_TITLE: Contribution of the paternal histone epigenome to embryo development and pregnancy loss

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ORG_CITY: TUSCALOOSA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF ALABAMA IN TUSCALOOSA

ORG_STATE: AL

PHR: Project Narrative Mechanistic details pertinent to heme enzymatic pathways that interconvert nitrogen oxides are cornerstones to a variety of pathogenic situations in humans, and yet they continue to be faintly understood. The central goal of this project is to unveil detailed insights into these reaction landscapes using meticulously designed synthetic model systems that closely mimic those reactivities. Outcome of this work will therefore directly benefit the understanding of the origination and progression of a medley of disease conditions, and will contribute toward escalating the effectivity and precision of next generation therapeutics.

PI_NAMEs: WIJERATNE, GAYAN B (contact)

PROJECT_TITLE: Mechanistic Investigation into Nitric Oxide Interconversion Pathways of Heme Enzymes using Synthetic Mimics

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Machine Learning and Artificial Intelligence;Neurosciences;Regenerative Medicine

ORG_CITY: TROY

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: RENSSELAER POLYTECHNIC INSTITUTE

PHR: Controlling the properties of biomedical interfaces is critical for studying, diagnosing, and treating disease. This research program aims to develop a versatile platform based on interfacial protein self-assembly for increasing the functionality of biomedical and biological surfaces. Proof-of-concept projects explored in the proposed work include enhancing nerve tissue repair using coatings with temporally orchestrated growth factor release, improving the long-term performance of biosensors, and engineering live cell surfaces to control cell fate in therapeutic applications.

PI_NAMEs: ZHA, RUNYE HELEN (contact)

PROJECT_TERMS: Address;Behavior;Biological;Biological Models;Biological Process;biomacromolecule;biomaterial compatibility;biomaterial development;Biomimetic Materials;Biosensor;Cell Fate Control;Cell surface;Cells;Chemistry;Combinatorial Synthesis;Development;Diagnosis;Disease;Engineering;Equipment;Exhibits;Fibroins;Growth Factor;Implant;improved;innovation;interfacial;Interfacial Phenomena;Machine Learning;Nerve Tissue;neurotrophic factor;novel strategies;Outcomes Research;Peptides;Performance;Phenotype;prevent;Process;programs;Property;Proteins;rational design;release factor;Reporting;Research;Research Personnel;Schwann Cells;self assembly;Signal Transduction;Silk;Structural Protein;Structure;Surface;System;Therapeutic;tissue regeneration;tissue repair;tool;Work


NIH_SPENDING_CATS: Bioengineering;Genetics;Machine Learning and Artificial Intelligence;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LARAMIE

ORG_NAME: UNIVERSITY OF WYOMING

ORG_STATE: WY

PHR: Project Narrative Understanding the multifunctional roles of proteins is essential for designing therapeutic strategies to treat genetic causes of disease, yet our knowledge of these secondary roles for many proteins remains incomplete. We will elucidate the multifunctional roles of a protein involved in cancer, microcephaly, and infertility, while also using our expertise in high resolution 3D X-Ray imaging and artificial intelligence to establish an experimental workflow that will accelerate the discovery of multifunctional protein roles in model organisms such as Drosophila melanogaster and Xenopus laevis.

PI_NAMEs: SCHOBORG, TODD  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Affect;Animals;Architecture;Artificial Intelligence;ASPM gene;Atlases;Award;Biological;Biological Models;Brain;Cell Physiology;cell type;Cells;clinically relevant;Collaborations;Communities;Data;Databases;Defect;design;Development;Disease;Drosophila melanogaster;Drosophila melanogaster Proteins;effective therapy;fly;Future;gene function;Genes;Genetic;Genotype;Germ Lines;Growth;Health;high resolution imaging;Human;Image;Imaging technology;Infertility;insight;Investigation;Knowledge;Laboratories;Malignant Neoplasms;Microcephaly;Mission;Mitotic;model organism;Modernization;Mushroom Bodies;mutant;National Institute of General Medical Sciences;Notch Signaling Pathway;novel;Orthologous Gene;Pathway interactions;Phenotype;Productivity;Proteins;Rana;Research Personnel;Resolution;Role;stem cell function;stem cell population;stem cells;Therapeutic;Time;Tissues;tomography;tool;Update;virtual repository;Vision;Work;X-Ray Medical Imaging;Xenopus laevis

PROJECT_TITLE: Defining multifunctional roles for proteins in development and disease


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics

ORG_CITY: FAYETTEVILLE

ORG_NAME: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE

ORG_STATE: AR

PHR: PROJECT NARRATIVE While gene therapy has made major strides in the treatment of a broad range of diseases, many mechanisms that control long-term expression and phenotypic improvements remain unknown. This work aims to build an in- depth analysis of the genetic and cellular determinants of gene therapy longevity which is consistent with the goals of NIGMS.

PI_NAMEs: NELSON, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: adaptive immune response;Address;Animals;Behavior;Biological;Biology;Blindness;Cardiac;Cells;Cessation of life;Clinic;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Data;delivery vehicle;Dependence;Dependovirus;design;Disease;DNA sequencing;Dose;Epigenetic Process;epigenomics;gene correction;gene editing technology;gene replacement therapy;gene therapy;Genes;genetic analysis;Genetic Transcription;genome editing;Genomics;Goals;Hemoglobinopathies;Immune response;improved;Inherited;Length;Liver;Longevity;Mediating;Methods;Molecular;nanopore;National Institute of General Medical Sciences;Outcome;Phenotype;precision medicine;programs;promoter;Research;Skeletal Muscle;Spinal Muscular Atrophy;Techniques;Tissues;tool;Transcript;transcriptomics;Treatment Failure;vector;vector genome;Viral Genome;Work

PROJECT_TITLE: Exploring genomic and cellular determinants of gene therapy durability


NIH_SPENDING_CATS: Genetics

ORG_CITY: ANN ARBOR

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Stress is a key driver of several chronic diseases, with toxic exposures resulting in elevated mortality across all ages. When stressed, mammalian cells invoke counter measures that are crucial for their survival and restoration of homeostasis, while aberrations in these stress response programs are hallmarks of ageing, degenerative pathologies, and cancer. The proposed research investigates transcriptional responses to environmental stress, which has broad implications in understanding the basis of organismal resilience and unraveling new disease mechanisms, diagnostics, and therapeutics for a range of stress-associated pathologies.

PI_NAMEs: PITCHIAYA, SETHURAMASUNDARAM  (contact)

PROJECT_TERMS: Age;Aging;biological adaptation to stress;Cell model;Cells;Cellular Stress;Chronic Disease;Data;Diagnostic;Disease;Down-Regulation;environmental stressor;Epigenetic Process;epigenomics;Exposure to;Gene Expression;Genes;Genetic Transcription;genomic locus;Goals;hallmarks of aging;Heat shock factor;Homeostasis;Image;Individual;Lead;Link;Malignant Neoplasms;Mammalian Cell;Measures;Mediating;Membrane;Molecular;molecular imaging;mortality;Nerve Degeneration;novel;Nuclear;Osmosis;Pathology;Physical condensation;Physiology;programs;Protein Biosynthesis;Proteome;proteostasis;proteotoxicity;Renal Carcinoma;Research;resilience;response;restoration;RNA chemical synthesis;RNA metabolism;single molecule;Site;Stress;stressor;System;Technology;Therapeutic;Toxicant exposure;Transcript;transcription factor;Transcription Initiation;transcription termination;Transcriptional Regulation;transcriptome sequencing;Virus Diseases;Work

PROJECT_TITLE: Dissecting mechanisms of transcriptional regulation during stress


ORG_CITY: COLLEGE STATION

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: PROJECT NARRATIVE This proposal seeks to leverage the research and teaching strengths of TAMU, a large R1 institution and PVAMU, a partner R2 institution, and the premier HBCU in Texas, to train a diverse group of skilled scientists to excel at both teaching and research using a successful research-intensive community mentoring model. It is expected that this IRACDA-trained cadre of scientist-educators will partner with undergraduate institutions to increase science literacy and interest among historically underserved student populations and serve to recruit a new generation of scientists into biomedical and health research.

PI_NAMEs: MIRANDA, RAJESH C (contact);QUICK, CHRISTOPHER M;REGISFORD, E GLORIA CLAUDETTE

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Adopted;Biomedical Research;Black race;bridge program;Communities;Education;education research;Educational process of instructing;Equity;Faculty;faculty research;Foundations;Grant;Hispanic;Hispanic-serving Institution;Historically Black Colleges and Universities;Institution;Instruction;Leadership;Learning;Mentors;Modeling;Participant;post-doctoral training;Productivity;programs;Research;Research Project Grants;skills;Texas;Training;Training Programs;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Populations;Universities;Work

PROJECT_TITLE: IRACDA at Texas A&M University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Rehabilitation

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE This R01 project is a multi-site clinical trial of transcranial magnetic stimulation-electroencephalography (TMS- EEG), whose goal is to determine whether TMS-EEG measurements of brain complexity detect and predict recovery of consciousness in critically ill patients with acute severe brain injuries. The clinical motivation for this trial is that TMS-EEG measurements of brain complexity have the potential to improve the accuracy of diagnosis and prognosis in the intensive care unit, thereby informing decisions about life-sustaining therapy for patients with severe brain injuries. We will also use functional MRI and EEG in this project to provide mechanistic insights into the brain network connectivity properties that underly TMS-EEG measurements of brain complexity.

PI_NAMEs: BOLY, MELANIE ;EDLOW, BRIAN L. (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Academy;Acute;Acute Disease;Address;Affect;Age;American;Aphasia;Beds;Behavior;Behavior assessment;Behavioral;Brain;Brain Injuries;Bypass;Cause of Death;Chronic;Chronic Brain Injury;Clinical;Cognitive;Collaborations;Coma;Complex;Congresses;connectome;Conscious;Consciousness Disorders;Critical Care;Critical Illness;Detection;detection sensitivity;Devices;Diagnostic;diagnostic accuracy;Diagnostic Equipment;Diagnostic tests;diagnostic tool;diagnostic value;disability;Electroencephalography;Electrophysiology (science);European;experience;Family;Foundations;Functional Magnetic Resonance Imaging;Future;General Hospitals;Genetic Complementation Test;Glasgow Coma Scale;Goals;Guidelines;improved;Independent Living;indexing;Individual;Infrastructure;Injury;insight;Intensive Care Units;International;Life;life-sustaining therapy;long term recovery;loved ones;magnetic resonance imaging/electroencephalography;Maps;Measurement;Measures;Methodology;Methods;Minimally Conscious States;Monitor;Motivation;Motor output;Motor Pathways;Multi-Institutional Clinical Trial;Neurologist;Neurology;neurophysiology;neurotechnology;Noise;novel;Outcome;Pain;patient prognosis;Patients;Performance;Peripheral;Persons;pharmacologic;Physical Medicine;Physiologic pulse;premature;prevent;Prognosis;prognostic;prognostic tool;prognostic value;Property;Publishing;Recovery;Recovery of Function;Reference Standards;rehabilitation research;Reproducibility;Rest;Sedation procedure;sensory system;Signal Transduction;Site;Sleep;Stimulus;Testing;tool;Transcranial magnetic stimulation;Translating;Translations;Unconscious State;Universities;Vegetative States;Ventilator;Wisconsin;Withdrawal

PROJECT_TITLE: Measuring Brain Complexity to Detect and Predict Recovery of Consciousness in the ICU

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-Q (91)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: NARRATIVE Modeling of cell-specific LRP1 signaling in acute myocardial infarction The American Heart Association estimates that every 42 seconds an American will have an acute myocardial infarction (AMI), and despite the improvement in treatment and prognosis, a significant number of patients continue to die and AMI survivors remain at high risk of developing heart failure (HF). Low-density lipoprotein receptor related protein-1 (LRP1) is a membrane receptor known as a scavenger for the serine protease inhibitors (SERPINs) that also possesses anti-inflammatory and pro-survival signals in cultures cardiomyocytes and proliferative signals in fibroblasts. We propose that using modeling to define the differential signaling pathways of LRP1 in cardiomyocytes and cardiac fibroblasts may open the way to novel therapeutic strategies targeting LRP1 in AMI, heart failure, and other related diseases.

PI_NAMEs: ABBATE, ANTONIO ;SAUCERMAN, JEFFREY J. (contact);TOLDO, STEFANO

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: Acute;Acute myocardial infarction;Address;Agonist;American;American Heart Association;Anti-Inflammatory Agents;Binding;Cardiac;Cardiac Myocytes;Cardiotoxicity;Cell model;Cell Survival;cell type;Cells;Cessation of life;clinically relevant;Complex;Computer Models;Computing Methodologies;Cytoprotection;Data;Disease;Dissection;Drug Modelings;Experimental Animal Model;experimental study;Fibroblasts;Fibrosis;Gene Deletion;Genes;healing;Heart failure;high risk;Hypoxia;improved;in vivo;Incidence;Infarction;Influentials;innovation;insight;Ischemia;Knockout Mice;Knowledge;LDL-Receptor Related Protein 1;Ligands;Link;Lipoprotein Receptor;Logic;Macroglobulins;Mediating;Medical;Membrane;Methods;Modeling;mouse model;Multienzyme Complexes;Multiomic Data;Mus;network models;novel;novel therapeutic intervention;novel therapeutics;Organ;Pathway interactions;Patients;Peptides;Pharmaceutical Preparations;pharmacologic;Phenotype;PIK3CG gene;Population;predictive modeling;Prevalence;prevent;Process;Prognosis;Proliferating;Proteins;receptor;receptor expression;Reperfusion Injury;Reperfusion Therapy;Research;response;Role;Serine Proteinase Inhibitors;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Survivors;System;Testing;Therapeutic;therapeutic target;Toxic effect;Trypsin;wound healing;years of life lost

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE The program aims to develop novel intravital two-photon microscopy techniques with scattering correction for deep tissue imaging. By jointly developing optical hardware and computational software, the proposed techniques will correct dynamic tissue scattering with high-speed, high-efficiency light modulation. This program will offer a timely and reliable solution for imaging intact tissues and organs, catalyzing a broad range of fundamental biological research, including the imaging of nervous systems, immune responses, embryo development, and cancer metastasis.

PI_NAMEs: XUE, YI  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 3-Dimensional;Algorithms;Alzheimer's Disease;Biological;biological research;bone;Bone Marrow;Brain;Cell Physiology;Cellular Structures;Collaborations;Comprehensive Cancer Center;Computer software;Coupling;deep learning;Embryonic Development;Environment;experimental study;Face;Goals;Hematopoietic stem cells;Image;Imaging Techniques;Immune response;innovation;intravital imaging;intravital microscopy;Light;Lighting;lymph nodes;Microscopy;multiphoton microscopy;Mus;Neoplasm Metastasis;nervous system imaging;Neurons;Noise;novel;optical imaging;Optics;Organ;Organism;Pattern;prevent;Process;programs;Refractive Indices;Research;Resolution;Sampling;Signal Transduction;Speed;Structure;System;Techniques;Tissue imaging;Tissues;transmission process;two photon microscopy;Visualization

PROJECT_TITLE: Computational two-photon microscopy for deep tissue imaging


NIH_SPENDING_CATS: Cancer;Natural Products

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Project Narrative The PI3K signaling pathway is one of, if not the most, commonly activated pathways in human cancers. Although a small number of FDA approved PI3K inhibitors have reached the market in recent years, there remains a pressing need for more potent and selective therapeutics and chemical tools. This project will use a combination of evolutionally and biosynthetic considerations to prepare a large family of natural product-derived anticancer drug-leads/chemical probes, which have the potential to significantly bolster our arsenal of available cancer treatments.

PI_NAMEs: NEWTON, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Anabolism;analog;Animals;anticancer activity;Antineoplastic Agents;Back;Bacteria;Biological;cancer therapy;Chemicals;Development;Docking;drug development;drug discovery;Drug Industry;Evolution;Family;Family member;FDA approved;fungus;halenaquinone;Human;improved;inhibitor;innovation;Lead;Malignant Neoplasms;Marketing;Medicine;Natural Products;Natural Selections;Nature;novel anticancer drug;Organism;Pathway interactions;Pharmaceutical Preparations;PIK3CG gene;Plants;Process;Program Development;Reagent;Route;Scientist;screening program;Signal Pathway;Structure;Therapeutic;tool;Translating;wortmannin

PROJECT_TITLE: Convergent Evolution in Natural Product Biosynthesis


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: ARLINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS ARLINGTON

PHR: PROJECT NARRATIVE RNA interference (RNAi) is a highly conserved mechanism of regulation that silences a wide range of targets in a precise, temporal, and cell-specific manner to ensure proper execution of many essential cellular and physiological processes; yet we know almost nothing about how RNAi pathways are regulated in any organism. Defects in RNAi cause devastating gene mis-regulation and allows de-repressed transposons to wreak havoc on the genome, resulting in the onset of cancers, infertility, neurodegenerative disorders, and many other diseases; therefore, it is critical we gain a mechanistic knowledge of how balancing between the interdependent RNAi pathways is maintained, and how RNAi homeostasis is impacted by real-world stresses, to advance our understanding of small RNAs in human health and disease. Work from this proposal will provide the foundation for our mechanistic understanding of the higher order interactions between RNAi pathways that ensure cellular homeostasis and will be of key importance in determining the underlying causes of RNAi-mediated disease states and identifying potential therapeutic targets, in line with the NIH mission to reduce the burden of human illness.

PI_NAMEs: ROGERS, ALICIA KATHRYN (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Address;Architecture;Biomedical Engineering;Cell Physiology;Cells;Complex;Critical Pathways;Defect;derepression;Development;Disease;Ensure;Equilibrium;Eukaryota;experimental study;Feedback;Fostering;Foundations;Gene Expression;Gene Expression Regulation;Genes;Genetic Diseases;Genome;Goals;Health;Homeostasis;Human;improved;Infertility;Knowledge;Maintenance;Malignant Neoplasms;Mediating;Mission;Modeling;Molecular;mutant;Neurodegenerative Disorders;novel;Organism;Pathway interactions;Physiological;Physiological Processes;preservation;programs;Proteins;Regulation;RNA Interference;RNA Interference Pathway;Small RNA;Sorting;Sterility;Stress;stressor;Synthetic Genes;Techniques;Therapeutic;therapeutic target;Transcript;tumorigenesis;United States National Institutes of Health;Work

PROJECT_TITLE: Understanding what regulates a regulator: the molecular basis for homeostatic small RNA-mediated gene regulation

STUDY_SECTION: MRAF

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - F Study Section[MRAF]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The three-dimensional (3D) genome folding organization within the nucleus plays a key role in epigenomic regulation but whether and how changes in the 3D organization of cancer genomes drive tumorigenesis is not well understood. In this proposal, we aim to elucidate the functional importance and regulation of 3D genome alterations during lung adenocarcinoma progression in vivo. Study results may establish in situ 3D genomics as a new tissue-based modality for diagnostic, prognostic, and therapeutic biomarker development in cancer.

PI_NAMEs: MUZUMDAR, MANDAR DEEPAK (contact);WANG, SIYUAN

PROGRAM_OFFICER_NAME: DIVI, RAO L

PROJECT_TERMS: 3-Dimensional;Address;Adenocarcinoma Cell;adenoma;Algorithms;Atlases;Binding;Biological Models;biomarker development;cancer cell;cancer genome;cancer therapy;Carcinoma in Situ;Cell model;Cell Nucleus;Cells;Chromatin;chromosome conformation capture;Cleavage Under Targets and Release Using Nuclease;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Data;Development;diagnostic biomarker;Disease;Environment;Enzymes;EP300 gene;Epidermal Growth Factor Receptor;Epigenetic Process;epigenetic profiling;epigenomics;Exhibits;experimental study;Gene Expression;Gene Expression Profiling;gene repression;Generations;Genes;Genetic;Genome;genome analysis;Genomics;Histologic;Histones;Human;human disease;Image;In Situ;in vivo;Individual;knock-down;Knock-out;Knowledge;KRAS2 gene;Ligase;LoxP-flanked allele;Lung;Lung Adenocarcinoma;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;MAP2K1 gene;Mediating;Methods;Modality;Modeling;Molecular;Molecular Conformation;mouse model;Mus;neoplastic cell;novel;Oncogenic;Pancreas;pancreatic cancer model;Pancreatic Ductal Adenocarcinoma;Pathogenicity;pharmacologic;Phosphorylation;Physiology;Play;Population;PRC1 Protein;predictive marker;Prognostic Marker;Proliferating;recruit;Regulation;Reporting;Role;Sampling;Technology;Testing;therapeutic biomarker;Tissues;transcription factor;Transcriptional Regulation;transcriptome sequencing;tumor;tumor barcoding and sequencing;Tumor Biology;tumor progression;Tumor Promotion;tumorigenesis;tumorigenic;ubiquitin ligase;Work

PROJECT_TITLE: 3D genome reorganization drives cancer development

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Research on aging is currently hindered by a lack of high-sensitivity technologies capable of characterizing proteins in limited cell populations and biopsies. This proposal will develop a next-generation ultrahigh- sensitive instrument to enable the deep analysis of proteins in important biological models of aging.

PI_NAMEs: NEMES, PETER  (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Address;Adult;Age;age acceleration;age effect;Aging;Alzheimer's Disease;Alzheimer's disease model;Astacoidea;Biochemistry;Bioinformatics;Biological;Biological Assay;Biological Markers;Biological Models;Biopsy;Capillary Electrophoresis;Cell Compartmentation;Cell Culture Techniques;cell injury;Cell Line;Cell Physiology;Cell Survival;cell type;Cells;Cerebrospinal Fluid;Chemicals;Chemistry;Collection;college;Data;data acquisition;design;Detection;Deterioration;Development;Disease;disease model;Electrophysiology (science);Environment;Equilibrium;frailty;Goals;Health;healthy aging;Heterogeneity;Homeostasis;improved;In Situ;insight;instrument;Invertebrates;Knowledge;Laboratories;Link;liquid biopsy;Maryland;Mass Spectrum Analysis;Methods;Modeling;Molecular;Molecular Biology;multidisciplinary;Mus;nanoproteomic;Nervous System;neural;Neurodegenerative Disorders;neuronal circuitry;Neurons;Neurosciences;next generation;novel;Peptides;Performance;Physiological;Population;precision medicine;Process;Production;Progeria;Protein Analysis;protein degradation;Protein Fragment;Proteins;Proteolytic Processing;Proteome;Proteomics;proteostasis;Research;RNA;Sampling;Sodium Chloride;Spectrometry, Mass, Electrospray Ionization;stoichiometry;success;Synapses;System;Technology;technology development;technology validation;Testing;therapeutic target;Time;Tissues;tool;transcriptome;transcriptomics;translational study;Translations;Validation

PROJECT_TITLE: Ultrahigh-Sensitivity Mass Spectrometry for Scalable Proteomics

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Services;Lung;Pediatric;Prevention;Rural Health

ORG_CITY: TUCSON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Limited access to life-saving albuterol sulfate for respiratory distress impacts school children's health and education. The Stock Albuterol for Every “SAFE” School Program aims to address this issue, but faces implementation challenges, especially in rural areas. This research examines three implementation strategies with the goal of improving student health and safety nationwide.

PI_NAMEs: LOWE, ASHLEY ANNE (contact)

PROGRAM_OFFICER_NAME: ILIAS, MALIHA R

PROJECT_TERMS: Absenteeism;Address;Adopted;Adoption;Agonist;Albuterol;Albuterol Sulfate;Analysis of Variance;Arizona;Asthma;Awareness;Breathing;Child;Child Health;Chronic;cost;Cost Analysis;cost effective;cost effectiveness;Cost Effectiveness Analysis;cost-effectiveness ratio;County;data portal;design;Discipline of Nursing;E-learning;Education;Effectiveness;effectiveness/implementation hybrid;Emergency Situation;empowerment;Enrollment;Epinephrine;Evaluation;Event;evidence base;evidence based guidelines;Evidence based practice;experience;Face;follow-up;gaps in access;Glucagon;Goals;Health;health care service utilization;health care settings;Health Personnel;Home;Hospitalization;Hour;Human Resources;implementation barriers;implementation fidelity;implementation strategy;improved;incremental cost-effectiveness;Individual;Inhalators;innovation;Interview;Laws;Learning;Legal;Life;Maintenance;Measures;Medical;medication administration;meetings;Modeling;mortality;Naloxone;National Heart, Lung, and Blood Institute;non-compliance;Nurses;Parents;Personal Satisfaction;Pharmaceutical Preparations;Policy Maker;prevent;Prevention education;Prevention program;programs;Protocols documentation;Public Health;Public Health Nursing;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;reduce symptoms;relative cost;remediation;Reporting;Research;Resources;Respiratory distress;Respiratory Signs and Symptoms;Rural;rural area;rural setting;Safety;School Enrollments;Schools;Specific qualifier value;Standardization;Statutes and Laws;Students;symptom management;Time;Training;Training Programs;Variant;Youth

PROJECT_TITLE: Breathing Easier in Schools: Enhancing Adoption, Fidelity, and Effectiveness of the SAFE School Program through Innovation Implementation Strategies

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: Public Health Relevance Statement The goal of this project is to develop a new low cost, noninvasive ultrasound-based tool for imaging microvascular changes associated with peripheral arterial diseases. Specifically, the new method will have a significant impact on early detection as well as assessment of disease progression and the response to therapy.

PI_NAMEs: ALIZAD, AZRA  (contact);FATEMI, MOSTAFA

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: Amputation;Anatomy;Ankle;Arteries;Biological Markers;Biomedical Engineering;Blood flow;Blood Vessels;Cardiovascular system;Chronic Kidney Failure;claudication;Clinic;Clinical;clinical practice;Clinical Research;Clutterings;cohort;Collaborations;Complement;Contrast Media;cost;Data;Development;Diabetes Mellitus;Diagnosis;Diagnostic;diagnostic tool;disability;Disease;Disease Progression;Early Diagnosis;Early treatment;efficacy evaluation;Elderly;Endothelium;Environment;Event;Exercise;exercise intolerance;experience;Goals;high resolution imaging;Image;imaging biomarker;Imaging Device;imaging modality;Imaging Techniques;Impairment;in vivo;indexing;Injections;innovation;Intervention;Leg;Lower Extremity;Measurement;Measures;Methods;Microcirculation;Monitor;Muscle;Names;new technology;Noise;novel;novel imaging technology;patient oriented research;patient population;Patient-Focused Outcomes;Patients;Peripheral;Peripheral arterial disease;Physicians;Play;Populations at Risk;portability;pressure;Prevalence;public health relevance;quantitative imaging;Recurrence;Regulation;Research;Research Personnel;response;Risk;Role;screening;Sensitivity and Specificity;Signal Transduction;standard of care;Stenosis;Stimulus;Symptoms;Syndrome;Techniques;Technology;Time;tool;Translating;treatment response;ultrasound;Variant;Vascular Diseases;Vision;volunteer

PROJECT_TITLE: A Contrast-free Ultrasound-based Quantitative Angio Flow Imaging Technique to Assess Peripheral Arterial Disease of Lower Limb

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Gene expression is mediated by the activity of non-coding cis-regulatory elements, enhancers and repressors, that control the spatial and temporal context and level of transcription. Work in vertebrates has identified a causal relationship between the 3D folding of the genome into discrete territories and the control of gene regulation – disruption of 3D architecture results in aberrant gene regulation leading to dysgenesis and cancer. Using comparative and functional approaches, this project will investigate when 3D structures including TADs and factories emerged in animals and the role that 3D architecture plays in the establishment of cell fate, the progression of development, and, over evolutionary timescales, the generation of novel phenotypes.

PI_NAMEs: MARLOW, HEATHER A. (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: 3-Dimensional;Animal Model;Animals;Architecture;Biological Assay;Cells;Chromatin;comparative;Development;DNA;Enhancers;Evolution;flexibility;fly;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic;Genetic Transcription;Genome;Genome Mappings;Goals;Human;insight;Link;Malignant Neoplasms;Marine Invertebrates;Mediating;model organism;Molecular Conformation;Mus;Nematoda;novel;Nuclear;Organism;Pathologic;Phase;Phenotype;Phylogenetic Analysis;Play;programs;Property;Proteins;Regulatory Element;Research;Role;Shapes;Structure;Techniques;Technology;three dimensional structure;Transcription Process;Transcriptional Regulation;Untranslated RNA;Vertebrates;Work

PROJECT_TITLE: Evolution of 3D Genome Folding Mechanisms and Gene Regulatory Strategies in Metazoans


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Mental Health;Mental Illness;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE  Traumatic stress disproportionately impacts the biopsychosocial health of Black women experiencing homelessness (WEH), yet few models of trauma-focused care are tailored or accessible to this growing population. In partnership with two women’s homelessness organizations, we will conduct a randomized controlled trial of our co-adapted trauma-focused intervention—NurseNET—to determine its effects in treating PTSD, co-occurring symptoms, and improving SDoH outcomes in Black WEH. In so doing, we will generate the evidence necessary to scale a nurse-led model of care to mitigate the trauma burden faced by Black WEH and other disinvested populations, towards reducing health inequities in trauma-affected communities.

PI_NAMEs: DICKINS, KIRSTEN  (contact)

PROGRAM_OFFICER_NAME: MCNAMARA, KAREN MARIE

PROJECT_TERMS: 2 arm randomized control trial;Active Listening;Address;Affect;Anxiety;associated symptom;attentional control;barrier to care;biopsychosocial;Black Populations;Black race;black women;Cardiovascular Diseases;Caring;Chicago;Child;Cities;Clinical;Communication;Communities;Community Health;community partners;Complement;Complex;Conscious;design;Development;Dimensions;Disclosure;Discrimination;DSM-V;Economics;Elements;Evaluation;evidence base;experience;Face;Family;follow-up;Fostering;Health;health care availability;health equity promotion;health inequalities;Health Priorities;Health Professional;Health Promotion;Health Services Accessibility;Healthcare Systems;Homelessness;Human Rights;implementation outcomes;improved;Individual;Inequity;innovation;Intervention;Interview;lens;Life;Link;Lived experience;Measures;Mental Depression;Mental Health;Modeling;Nurses;Nursing Research;Outcome;Participant;peer;peer support;Perception;Persons;pilot test;Policies;Population;population health;Positioning Attribute;post-traumatic stress;Post-Traumatic Stress Disorders;Premature Mortality;Prevention;Process;Public Health;Race;racism;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Research;Resource-limited setting;response;Risk;secondary outcome;Self Efficacy;Services;Shelter facility;Sleep;social;social health determinants;Social support;stress symptom;substance use;Surveys;Symptoms;Trauma;trauma care;trauma exposure;traumatic stress;Trust;Woman;women of color

PROJECT_TITLE: Improving Traumatic Stress in Black Women Experiencing Homelessness: Evaluation of a Stakeholder Engaged Intervention

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Brain Disorders;Breast Cancer;Cancer;Genetics;Neurosciences;Women's Health Research

ORG_CITY: DALLAS

ORG_DEPT: PATHOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE Breast cancer patients positive for human epidermal growth factor receptor 2 are at a high risk of relapse with brain metastasis, months to years after the initial disease diagnosis and primary therapy. Proposed study will identify and characterize the tumor and host specific alterations that promote metachronous brain metastasis and assess the impact of AXL inhibitor in limiting tumor cell survival and reactivating NK mediated innate immune surveillance.

PI_NAMEs: MALLADI, SRINIVAS  (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: Affinity Chromatography;Attenuated;Automobile Driving;Binding;Biochemical;biological adaptation to stress;Biological Assay;Biological Models;Brain;Breast Cancer Cell;Breast Cancer Patient;cancer therapy;Cell Physiology;Cell Survival;Cells;Characteristics;ChIP-seq;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cytotoxic;cytotoxicity;disease diagnosis;Distal;effective therapy;Epidermal Growth Factor Receptor;Equilibrium;ERBB2 gene;experimental study;Family;fitness;Functional disorder;Genes;Genetic;Genome Stability;helicase;high risk;Human;Immune;Immune response;Immunologic Surveillance;Immunoprecipitation;Impairment;improved;In Situ;Incidence;inhibitor;innovation;loss of function;loss of function mutation;Maintenance;Malignant Breast Neoplasm;Mass Spectrum Analysis;Mediating;Mediator;member;Membrane;MERTK gene;Metabolic;Metastatic malignant neoplasm to brain;Metastatic/Recurrent;Modeling;Molecular;mortality;Mus;Natural Killer Cells;Neoplasm Metastasis;neoplastic cell;novel;Nuclear;Nuclear Localization Signal;Nuclear Proteins;Nuclear Translocation;Organ;Outcome;Phenotype;pre-clinical;Pre-Clinical Model;Primary Neoplasm;programs;promoter;Promoter Regions;Proteins;Proteomics;radioresistant;Receptor Protein-Tyrosine Kinases;Recurrence;Regulatory Element;Relapse;relapse risk;Research;Resistance;response;Role;Sampling;sensor;Series;Signal Transduction;Site;small molecule;standard of care;stemness;Stress;Surface;targeted treatment;therapy resistant;Training;transcription factor;transcriptomics;tumor;tumor growth;Tumor Promotion;TYRO3 gene;Variant

PROJECT_TITLE: Uncovering the Molecular Determinants of Metastatic Recurrence and Impaired NK Cell Function

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


NIH_SPENDING_CATS: Aging;Brain Disorders;Digestive Diseases;Microbiome;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE. The proposed project is relevant to public health because it focuses on identifying precisely how the gut microbiome contributes to the onset of Parkinson’s disease. This work is a critical next step toward developing new and needed therapeutics that target gut processes to prevent and treat this disease. Thus, the proposed research is relevant to the NIH’s mission that pertains to reducing illness and disability.

PI_NAMEs: BESS, ELIZABETH NANCY (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Address;Affect;alpha synuclein;Animals;Biochemical;Brain;Caenorhabditis elegans;Cells;Chemicals;clinical translation;Clinical Trials;clinically relevant;Coculture Techniques;diagnostic biomarker;Diet;disability;Discipline;Disease;Disease Progression;Dopamine;Early Intervention;Ecosystem;Enteral;Enteroendocrine Cell;Epithelial Cells;Escherichia coli;experimental study;gastrointestinal;Gastrointestinal tract structure;Genetic;gut bacteria;gut microbes;gut microbiome;gut microbiota;Human;In Vitro;innovation;intestinal epithelium;Intestines;Iron;Knowledge;Learning;Maps;Mediating;Methods;microbial;Microbiology;microbiome composition;microbiota;Mission;Modeling;Molecular;Molecular Biology;monomer;motor disorder;motor impairment;mouse model;Nerve Degeneration;Nervous System Disorder;Neurons;new therapeutic target;Nitrates;Nitrites;novel;Organometallic Chemistry;Oxidants;Oxidation-Reduction;Oxidative Stress;Parkinson Disease;Peptide Initiation Factors;Persons;Physiological;Physiology;Play;prevent;Process;protein aggregation;Proteomics;Public Health;Qualifying;Reporter;Research;Respiration;response;Role;Source;System;Testing;therapeutic candidate;therapeutic target;therapy development;Time;Tissues;tool;United States National Institutes of Health;Vagus nerve structure;Work

PROJECT_TITLE: Discovery of Chemical Factors in the Gut Microbiome that Control Alpha-Synuclein Aggregation in Parkinson's Disease

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: Project Narrative Gene silencing enzymes PRC1, PRC2, and DNMT1 are essential for maintaining cellular identity, and defects in these enzymes are some of the leading causes of leukemias and cardiac diseases. We will use chemical biology and a structure-guided approach to develop new inhibitors and activators targeting PRC2. We will use an integrated structural and functional approach to uncover the molecular mechanisms that activate PRC1 and DNMT1 on chromatin, which will enable the development of new therapeutic avenues targeting these enzymes.

PI_NAMEs: KASINATH, VIGNESH  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Biochemical;Biological Assay;Biology;cardiogenesis;Cell Differentiation process;cell type;Cells;Chemicals;Chromatin;Chromatin Remodeling Factor;Complex;Cryoelectron Microscopy;Defect;design;Development;disease-causing mutation;DNA;DNA Maintenance;DNA Methylation;DNA Modification Methylases;DNA replication fork;Embryonic Development;enzyme activity;Enzymes;Epigenetic Process;epigenetic silencing;Gene Silencing;Genes;Goals;Heart Diseases;Histone H3;histone methylation;Histones;Human body;inhibitor;insight;Lead;leukemia;Lysine;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Molecular;Monoubiquitination;Mutation;novel;novel therapeutics;Nucleosomes;Play;Polycomb;Post-Translational Protein Processing;PRC1 Protein;programs;recruit;Research;Role;small molecule;Solid Neoplasm;structural biology;Structure;tumor;ubiquitin-protein ligase;Vision;Work

PROJECT_TITLE: Structure and Mechanism of Epigenetic Gene Silencing

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - E Study Section[MRAE]


PHR: Project Narrative Ion channels are understudied in immune cells. This research proposal aims to identify and characterize novel ion channels and transporters to understand how they regulate the development and function of immune cells.

PI_NAMEs: CONCEPCION GONZALEZ, AXEL ROLANDO (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Action Potentials;Anions;Biochemistry;Cell membrane;Cell Physiology;Cells;Communication;Complex;Development;Dinucleoside Phosphates;Electrophysiology (science);functional genomics;Genes;Genetic;Goals;Human;Immune;immune function;Immune response;Immunology;Immunotherapy;Ion Channel;Ion Channel Protein;Ions;Membrane Proteins;Molecular;mouse model;Mus;Muscle Contraction;Muscle Fibers;Neurons;novel;null mutation;Periodicity;Physiological;Play;Proteins;Regulation;Research Proposals;Role;Signal Transduction;Signaling Molecule;Solid;structural biology;Swelling;System;T-Lymphocyte;Thymus Gland

PROJECT_TITLE: Immune cell regulation by swelling-activated ion channels

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


ORG_CITY: AUSTIN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative We aim to establish a research program that develops optical imaging technologies that overcome the challenge of tissue scattering, to achieve large-scale 3D imaging of tissue morphogenesis. If successful, this work will enable, for the first time, joint morphological and molecular imaging of deep-tissue morphogenetic events across entire developing embryos at subcellular resolutions. Furthermore, this work will lay the foundation for future imaging technologies that enable investigations into in-vivo biological processes taking place within their natural tissue environments.

PI_NAMEs: CHOWDHURY, SHWETADWIP  (contact)

PROJECT_TERMS: 3-Dimensional;adaptive optics;Biological;Biological Process;cell motility;Cells;Complex;Data;design;Development;Embryo;Environment;Event;Foundations;Future;Image;Image Enhancement;Imaging Techniques;Imaging technology;in vivo;Investigation;Joints;Light;Magnetic Resonance Imaging;mechanical stimulus;Microscope;Microscopy;millimeter;Modeling;Molecular;molecular imaging;Morphogenesis;Morphology;multi-photon;multimodality;optical imaging;Optics;Organ;Organism;planar cell polarity;Process;programs;Refractive Indices;Research;Resolution;Roentgen Rays;Sampling;Shapes;Signal Pathway;Speed;submicron;System;Technology;Three-Dimensional Imaging;Time;Tissue imaging;Tissues;tomography;tool;Travel;Visualization;Whole Organism;Work;Xenopus;Zebrafish

PROJECT_TITLE: Imaging deep-tissue morphogenesis at whole-organism scales

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-F (55)]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE The ability to remember one's features and monitor current states is fundamental for self-recognition, yet the mechanisms governing how neurons, circuits, and inter-regional functional connectivity in the brain accomplish visual self-recognition remain unknown. By taking advantage of a mouse model, our proposed study aims to demonstrate the most detailed functional map of the hippocampal-prefrontal cortical circuits that control visual self-recognition.

PI_NAMEs: KITAMURA, TAKASHI  (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Anatomy;Animals;Behavior;Birds;Brain;Brain imaging;Brain Mapping;Brain region;Cells;Communication;Data;Electrophysiology (science);experience;Experimental Animal Model;Exposure to;Fishes;Gene Expression;Generations;Genetic;Goals;Grooming;habituation;Head;hippocampal subregions;Hippocampus;Home;Human;Immediate-Early Genes;Impairment;Implant;in vivo calcium imaging;Ink;Macaca mulatta;Maps;Medial;member;Memory;Monitor;mouse model;Mus;Nature;neural;neural circuit;Neurons;nonhuman primate;novel;Parietal Lobe;Pathway interactions;Prefrontal Cortex;preservation;Presynaptic Terminals;Reporting;Role;Self Direction;Self Perception;social;somatosensory;Stains;Techniques;Testing;Training;Visual;visual control

PROJECT_TITLE: Neural circuit mechanisms for a mirror-induced self-directed behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-D (55)]


ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: PROJECT NARRATIVE DEAD-box ATPases remodel RNA:protein assemblies in cells to control gene expression programs, and their dysregulation contributes to human diseases. We propose to develop an integrated approach to understanding how the function of DEAD-box proteins can be controlled with chemistry-based tools. By learning what determines the specificity and efficacy of chemical DEAD-box protein modulators, we will enable the design of powerful probes to study the roles of RNA in gene regulation and to test hypotheses for developing new therapeutics.

PI_NAMEs: CUPIDO, TOMMASO  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Affinity;ATP phosphohydrolase;Biochemistry;Biological;Biological Process;Biology;Catalytic Domain;Cell Communication;Cells;Cellular biology;Chemicals;Chemistry;cofactor;Collection;Communication;Complex;Computing Methodologies;design;Disease;Distal;driving force;Ewings sarcoma;Gene Expression;Gene Expression Regulation;Genes;Genetic;Glues;human disease;Human Genome;Infection;inhibitor;Learning;Ligand Binding;Ligands;Malignant Neoplasms;multidisciplinary;Mutation;Nerve Degeneration;Neurodegenerative Disorders;novel therapeutics;Nucleic Acids;Nucleotides;Physical condensation;Play;Process;programs;Protein Dynamics;Protein Family;protein phosphatase inhibitor-2;Proteins;rare genetic disorder;Ribonucleoproteins;Ribosomes;RNA;RNA Helicase;RNA Polymerase II;RNA-dependent ATPase;RNA-Protein Interaction;Role;Saint Jude Children's Research Hospital;screening;Specificity;Spliceosomes;Structure;Synthesis Chemistry;Testing;tool;X-Ray Crystallography

PROJECT_TITLE: Chemical approaches for targeting ribonucleoprotein assemblies


NIH_SPENDING_CATS: Clinical Research;Hematology;Kidney Disease;Rare Diseases

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: Project Narrative Development of specific therapies for idiopathic renal disease has been hampered by poor stratification of disease entities and a lack of understanding of underlying disease mechanisms. Our published and preliminary findings highlight a novel and central role for the bone marrow immune system in the pathogenesis of renal disease. Thus, we aim to explore the bone marrow-kidney axis as a novel target that improves current patient stratification and provides targets for the eventual development of effective treatments.

PI_NAMEs: HAHM, EUNSIL ;REISER, JOCHEN  (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: Adult;Affect;Albumins;Biological Assay;Blood Cells;Bone Marrow;Bone Marrow Aspiration;Bone Marrow Cells;Bone Marrow Transplantation;candidate identification;Categories;CD14 gene;Cell Lineage;Cell Physiology;Chronic;cytokine;Data;Development;Diagnosis;differentiation in vitro;Disease;Disease stratification;effective therapy;End stage renal failure;Exhibits;experience;FCGR3B gene;Focal and Segmental Glomerulosclerosis;glomerular filtration;Goals;granulocyte;Health;Hematopoiesis;hematopoietic stem cell differentiation;Hematopoietic stem cells;Human;humanized mouse;IL8 gene;Immune;Immune system;Immunologic Factors;improved;In Vitro;in vitro Assay;in vivo;Incidence;Individual;Inflammation;Inflammatory;Injury to Kidney;Interleukin-6;Kidney;Kidney Diseases;Kidney Transplantation;Macrophage;Mediating;Modeling;Molecular;monocyte;Mus;Myelogenous;Myeloid Cells;Myeloid Progenitor Cells;Myelopoiesis;Nature;Nephrotic Syndrome;novel;novel therapeutic intervention;novel therapeutics;Pathogenesis;Pathogenicity;Pathway interactions;patient stratification;Patients;Permeability;Phenotype;Plasma;prevent;Production;progenitor;Proteinuria;Publishing;Recurrence;Recurrent disease;Remission Induction;Renal function;Renal glomerular disease;Role;side effect;Signal Transduction;Source;System;targeted treatment;Testing;Therapeutic Effect;Therapeutic immunosuppression;Urokinase Plasminogen Activator Receptor;Zebrafish

PROJECT_TITLE: Targeting bone marrow to treat renal disease

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because fibrillar adhesins are widely used by bacteria in infection and persistence, and as such are desirable targets for anti-virulence therapeutics. The project is relevant to the mission of NIGMS because our discoveries will increase our fundamental understanding of fibrillar adhesin structure and function and provide a roadmap for the study of structurally similar proteins, laying the groundwork for advances in therapeutics for a range of human diseases.

PI_NAMEs: REICHHARDT, COURTNEY  (contact)

PROJECT_TERMS: Address;Adherence;Adhesives;Award;Bacteria;Bacterial Adhesins;Bacterial Adhesion;Bacterial Attachment Site;bacterial community;biophysical analysis;Biophysics;Characteristics;Chronic;Dedications;Environment;extracellular;Extracellular Matrix Proteins;Future;Homology Modeling;human disease;Infection;insight;Investigation;Knowledge;Length;Mediating;Mentors;Microbial Biofilms;Microbiology;Mission;Modeling;Molecular;Molecular Weight;monomer;National Institute of General Medical Sciences;novel strategies;Play;prevent;protein structure;Proteins;Proteome;Pseudomonas aeruginosa;Public Health;rational design;Repetitive Sequence;Research;Resources;Role;Scientist;Structure;Surface;Therapeutic;therapeutic target;Time;Tissues;Training;Virulence

PROJECT_TITLE: Structural and functional investigations of bacterial fibrillar adhesins

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Precision Medicine;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Project Narrative Adenoid Cystic Carcinoma (ACC) is a salivary gland head and neck cancer with high recurrence rate and despite the significant biological and clinical variability, all patients are treated the same. There is no standard of care systemic therapies for patients with this orphan disease. This proposal is pertinent to public health because it will identify clinically significant, reliable, prognostic, and predictive DNA methylation biomarkers, which will address a clinical gap-specifically, the lack of biomarkers for prognostication, and to guide patient stratification for treatment selection in ACC. Thus, our proposed research is relevant to the part of NIH’s mission that pertains to developing fundamental knowledge that will help to reduce the burdens of human illness.

PI_NAMEs: FERRAROTTO, RENATA  (contact);HEEKE, SIMON

PROGRAM_OFFICER_NAME: BHARTI, SANITA

PROJECT_TERMS: accurate diagnosis;Address;Adenoid Cystic Carcinoma;Affect;Aggressive behavior;Behavior;Biological;Biological Markers;Blood;Blood specimen;Blood Tests;blood-based biomarker;Chromatin;Classification;Clinic;Clinical;clinical predictors;Clinical Trials;clinically relevant;clinically significant;cohort;Databases;Detection;Diagnosis;Disease;Disease Progression;disorder subtype;DNA;DNA Integration;DNA Methylation;Epigenetic Process;epigenetic regulation;Epithelial Cells;Evolution;fitness;Gene Expression;Genes;Genetic Transcription;genome-wide;Gland;Goals;Head and Neck Cancer;Heterogeneity;Histology;Human;Indolent;innovation;Inter-tumoral heterogeneity;Knowledge;Link;liquid biopsy;Local Therapy;Longterm Follow-up;Low Prevalence;Lung;Malignant neoplasm of salivary gland;Malignant Neoplasms;Methylation;methylation biomarker;methylome;Mission;Molecular;Molecular Disease;molecular subtypes;Monitor;multidisciplinary;multimodality;Mutation;Neoplasm Metastasis;Neoplastic Cell Transformation;NOTCH1 gene;Operative Surgical Procedures;participant enrollment;Pathologist;patient stratification;Patients;pre-clinical;Prediction of Response to Therapy;Primary Neoplasm;Prognosis;prognostic;prognostication;prospective;Prospective Studies;proteogenomics;Public Health;Radiation therapy;Rare Diseases;Recurrence;Recurrent disease;Research;response;Risk;RNA;RNA Degradation;Salivary Glands;Selection for Treatments;Site;Solid;Somatic Mutation;standard of care;Stratification;Systemic Therapy;Testing;Therapeutic;therapeutic target;Time;Tissue Banks;Tissues;tool;transcriptome;transcriptomic profiling;transcriptomics;Translating;Translational Research;translational scientist;treatment response;treatment stratification;Tubular formation;tumor;tumor DNA;tumor heterogeneity;tumor progression;tumorigenesis;United States National Institutes of Health;Up-Regulation;VTCN1 gene

PROJECT_TITLE: Harnessing Tumor and Circulating-Free DNA Methylation for Prognosis and Treatment Stratification in Adenoid Cystic Carcinoma

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Pediatric;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative The proposed research is both relevant to public health and aligned with the National Institutes of Child Health and Human Development’s mission; we will test the efficacy of an intervention designed to improve maternal and infant health by empowering clinicians with skills to enhance patients’ access to continued gainful employment and accommodation to ensure a safe working environment during pregnancy. Data gathered during the randomized trial, including electronic health record review, patient survey and qualitative interviews will also be leveraged to support diverse medical students as they participate in a year-long mentored career development and obstetric health disparities research program. We will enhance diversity in biomedical research by conducting a rigorously designed trial in collaboration with a patient- and community-engaged multidisciplinary team while mentoring medical students poised to become the next generation of clinician scientists dedicated to eradicating health disparities in maternal and infant health.

PI_NAMEs: WHEELER, SARAHN  (contact)

PROGRAM_OFFICER_NAME: FABIYI, CAMILLE

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Affect;Appointment;Area;Awareness;Biomedical Research;Birth;black patient;Black race;career;career development;Caring;Clinic;Clinical;Clinical Investigator;Cluster randomized trial;cohort;Collaborations;Communities;community organizations;Computerized Medical Record;Counseling;Coupled;Data;Data Set;Dedications;Development;didactic education;Discipline of obstetrics;Discrimination;Documentation;E-learning;Economics;Education;Educational Curriculum;Educational Intervention;effectiveness evaluation;efficacy evaluation;efficacy testing;Electronic Health Record;Employment;empowerment;Ensure;Environment;Equity;equity, diversity, and inclusion;evidence base;experience;Face;Family;Feeling;Frequencies;Grant;Health;Health Disparities Research;health disparity;health empowerment;health equity;Health equity research;implementation science;Improve Access;improved;Income;Infant Health;Institution;Interruption;Intervention;Interview;Knowledge;Laws;Leadership;Low Birth Weight Infant;Maternal Health;Maternal Health Services;Maternal-fetal medicine;Medical;medical schools;Medical Students;Medicine;member;Mental Depression;Mentors;Mentorship;Methods;Minor;Minority;Mission;multidisciplinary;National Institute of Child Health and Human Development;next generation;obstetric care;Occupations;Outcome;patient engagement;Patients;Persons;pilot test;Positioning Attribute;Postpartum Period;Pregnancy;pregnancy health;Pregnancy Outcome;pregnant;Prenatal care;programs;Provider;Public Health;Qualitative Research;Race;Randomized;randomized trial;Recommendation;recruit;Reporting;Research;Research Methodology;Research Project Grants;Research Training;Resources;response;Rights;Safety;Science;Scientist;skills;social health determinants;socioeconomics;Stress;Students;Surveys;Testing;therapy design;tool;Training;Translating;treatment as usual;trial comparing;trial design;two-arm study;Underrepresented Minority;Wages;Work;Workplace

PROJECT_TITLE: PROMOTE and TEACH Equity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-G (55)]


NIH_SPENDING_CATS: Genetics;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative Many hormones act via the signaling protein Gsα, which is produced by the GNAS complex gene. Disruption of Gsα activity causes several human diseases due to impaired actions of multiple hormones, causing altered metabolism, derangements in serum calcium and phosphate levels, abnormal bone development, growth problems, and intellectual disability. To enhance our understanding of these disorders and, thus, improve their clinical management, we aim to elucidate the mechanisms regulating the production of Gsα from the GNAS gene in different hormone-responsive tissues.

PI_NAMEs: BASTEPE, MURAT  (contact)

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: Affect;Alleles;autocrine;Bone Development;Calcium;Cell Differentiation process;Cell model;Cells;Chondrocytes;Clinical Management;clinically significant;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Complex;curative treatments;Defect;derepression;Disease;Embryo;Enhancers;Epiphysial cartilage;Exons;Gene Abnormality;Gene Deletion;gene function;Genes;Genetic;Genetic Transcription;GNAS gene;Growth;GTP-Binding Protein alpha Subunits, Gs;GTP-Binding Proteins;Heterotopic Ossification;hormonal signals;hormone resistance;Hormone Responsive;Hormones;Human;human disease;human embryonic stem cell;human model;Hypocalcemia;Hypothyroidism;Impairment;imprint;improved;induced pluripotent stem cell;inorganic phosphate;Intellectual functioning disability;Knowledge;loss of function;Mediating;Metabolism;Methylation;Mutation;Neurotransmitters;Obesity;Organ;Osteoblasts;paracrine;Pathogenesis;Patients;Phenotype;Play;prevent;Production;Proximal Kidney Tubules;Pseudohypoparathyroidism;PTH gene;Publishing;Recurrence;Regulation;Resistance;Role;Serum;Signal Transduction;Signaling Protein;Skeletal Development;stem cell model;Testing;Therapeutic;Thyroid Gland;Thyrotropin;Tissue Differentiation;Tissues;tool;Transcript

PROJECT_TITLE: Control of allelic Gsα expression for regulating hormone signaling

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Nutrition;Prevention;Social Determinants of Health

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE Food insecurity increased sharply at the onset of the COVID-19 pandemic, and in response, the federal government took unprecedented steps to increase nutrition benefits (emergency allotments) for millions of low- income Americans through the Supplemental Nutrition Assistance Program (SNAP). A growing body of evidence suggests that food insecurity is associated with cardiovascular health, and so in this proposal, we will: (1) examine changes in food insecurity among low-income adults, including those with cardiometabolic risk factors, during and following the pandemic; (2) elucidate the pathways by which food insecurity impacts cardiometabolic health; and (3) estimate the spillover and health effects of SNAP benefits. To do so, we will leverage a natural experiment that occurred during the pandemic when US states de-implemented SNAP emergency allotments to estimate their impact on health care access and affordability, the prevalence, treatment, and control of cardiometabolic risk factors, and the incidence acute cardiovascular events.

PI_NAMEs: WADHERA, RISHI KUMAR (contact)

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: Acute;Adult;Affect;American;Biometry;Black race;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;cost;COVID-19 pandemic;Data;Data Set;Deimplementation;design;Diabetes Mellitus;Diet;Disease;Economics;Elderly;Emergency Situation;Equity;Ethnic Population;Evaluation;Event;experience;Federal Government;Food;food insecurity;food security;Goals;Government;Health;health care availability;health care service;Health Food;Heart failure;Hispanic;hospital readmission;Hospitalization;Household;Hyperlipidemia;Hypertension;improved;Incidence;interest;Interruption;Investments;Laboratories;Low income;lower income families;Medical;Medicare claim;Medicare/Medicaid;mortality;Myocardial Infarction;National Health and Nutrition Examination Survey;Natural experiment;nutrition;Obesity;Outcome;pandemic disease;Pathway interactions;Patient Self-Report;Persons;Pharmaceutical Preparations;Policies;Policy Maker;Prevalence;Preventive screening;Primary Care;programs;Public Health;Public Policy;Quasi-experiment;racial population;Research;Resources;response;Risk;Risk Factors;Rural;Series;Stroke;Subgroup;Surveys;Testing;Time;Unemployment;United States;urban residence;US State;Work

PROJECT_TITLE: Leveraging SNAP Policies to Improve the Cardiovascular Health of Low-Income Adults in the United States

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: TEMPE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

PHR: Project narrative The primary goal of this project is to develop machine learning based computational models for predicting protein interactions in the context of immune receptors and their antigen recognition. Additionally, these models can gen- erate immune receptors that can be used in a wide range of applications such as therapeutics, diagnostics, and studying the molecular basis of antigen recognition. Most importantly, the project seeks to provide a generalized principles of effectively representing biological sequences such that this work can be extended to different types of protein interactions.

PI_NAMEs: LEE, HEEWOOK  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Algorithms;Amino Acid Sequence;Antigens;B-Cell Antigen Receptor;Binding;Biological;Biological Assay;Cell Physiology;Cells;Communicable Diseases;Complex;Computational algorithm;computer framework;Computer Models;Computing Methodologies;design;Diagnostic;diagnostic tool;DNA Repair;effective therapy;Epitopes;Gene Expression Regulation;Goals;Health;Human;human disease;Immunologic Receptors;Knowledge;Language;Ligands;Machine Learning;machine learning model;Mainstreaming;Malignant Neoplasms;Modeling;Molecular;natural language;Natural Language Processing;new therapeutic target;novel;novel diagnostics;novel therapeutics;Outcome;Performance;predictive modeling;protein complex;Protein Engineering;Protein Family;Proteins;receptor;Research;Sequence Analysis;Signal Transduction;structural biology;Structure;Study models;T-Cell Receptor;T-cell receptor repertoire;Techniques;Therapeutic;vector;Work

PROJECT_TITLE: Machine Learning Models for Studying Protein Interactions in the Context of Immune Receptors


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Networking and Information Technology R&D (NITRD);Pediatric;Social Determinants of Health

ORG_CITY: Lincoln

ORG_NAME: DISCOVERY COLLECTIVE, INC.

ORG_STATE: NE

PHR: PROJECT NARRATIVE The Model It! project aims to significantly improve STEM education by transforming an emerging biomedical research-grade computational modeling and simulation technology into an interactive and engaging pedagogical gaming application for students in grades 5-8 after-school programs. By developing essential computational modeling and simulation skills, this project will equip the next generation of life science professionals with foundational competencies, promoting innovation in public health and biomedical research. The technology's widespread adoption will contribute to the development of a skilled workforce capable of addressing pressing public health challenges and advancing the field of systems biology.

PI_NAMEs: HELIKAR, RESA MARIE (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Academy;Address;Adoption;after-school program;Age;Air;Artificial Intelligence;Basic Science;Biological Models;Biological Sciences;Biomedical Research;Businesses;career;Cells;Child;Cities;Code;Competence;Computer Models;Computer Simulation;Computer software;design;Development;Devices;digital;digital media;Education;educational atmosphere;Educational process of instructing;Educational Technology;Effectiveness;effectiveness research;efficacy evaluation;eighth grade;Engineering;Ensure;Environment;experience;field study;Fostering;Foundational Skills;Goals;Graph;Health;Image;improved;informal learning;Infrastructure;innovation;Instruction;International;Internet;Journals;junior high school;Knowledge;Leadership;Learning;Length;Location;Marketing;Mathematics;medical specialties;Memory;model building;Modeling;models and simulation;Muscle;Museums;Nebraska;new technology;next generation;novel;Online Systems;Outcome;Peer Review;Phase;Population;programs;Public Health;quantum computing;recruit;Research;Research Personnel;Resources;Robotics;Rotation;Running;Schedule;school district;Schools;Science;science teacher;Science, Technology, Engineering and Mathematics;Science, Technology, Engineering and Mathematics Education;Secure;Series;simulation;skill acquisition;skills;Small Business Innovation Research Grant;student participation;Students;Systems Biology;Talents;Teacher Professional Development;Technical Expertise;Technology;technology development;Testing;Training;Translating;Universities;Work

PROJECT_TITLE: Scaling health and bioscience training technology to informal education

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (56)]