NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Cost Effectiveness Research;Data Science;HIV/AIDS;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE HIV is a top cause of death in sub-Saharan Africa, but rates of new infections are declining, so that HIV prevention services avert fewer infections per client served, and HIV testing services lead to fewer new HIV- positive diagnoses per test conducted. To increase the efficiency of these services, a rapid point-of-care test for recent HIV infection has been developed and is being used in over two-thirds of people newly diagnosed with HIV in Zambia in order to identify other people at risk or living with undiagnosed HIV in their social networks. We will use mathematical modeling to determine whether recency testing can help Zambia achieve epidemic goals, is a good use of limited resources, and can be improved upon using “big data” methods for greater precision, ease-of-use, and avoidance of potentially stigmatizing data elements.

PI_NAMEs: BERSHTEYN, ANNA  (contact)

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: Acceleration;Adopted;Adult;Africa South of the Sahara;Age;AIDS prevention;Antibody Avidity;antibody detection;authority;Avidity;Big Data;Big Data Methods;Bioethics;Botswana;Budgets;Cause of Death;Client;cohort;cost;cost effectiveness;cost estimate;Cost Measures;Country;Data;Data Element;Decision Making;design;Detection;Diagnosis;Disease Outbreaks;Epidemic;epidemic response;Epidemiology;Exposure to;Fingers;Goals;Guidelines;Health;Health Benefit;Health Care Costs;Health care facility;health economics;heuristics;HIV;HIV Antibodies;HIV Genome;HIV Infections;HIV Seropositivity;Home;Human immunodeficiency virus test;improved;Incidence;incremental cost;Individual;Infection;infectious disease model;Infectious Diseases Research;International;Intervention;Intuition;Investments;Lead;Lesotho;Life;Machine Learning;machine learning model;Maps;mathematical model;Measures;microcosting;Modeling;Mozambique;Namibia;network models;Network-based;Newly Diagnosed;next generation;novel;outbreak response;Paper;Pattern;Persons;Phylogenetic Analysis;Plasma;point of care;point of care testing;Policies;Policy Making;Population;Populations at Risk;Prevalence;prevention service;programs;Public Health;Radial;rapid test;Reaction Time;Resources;response;Role;Running;Sensitivity and Specificity;Sepsis;Serum;Services;Social Network;South Africa;Specificity;standard of care;Stigmatization;Sustainable Development;test strip;Testing;testing services;Time;tool;Training;transmission process;Venous;Work;Zambia

PROJECT_TITLE: Rapid Tests for Recent Infection (RTRI) for Precision Public Health in Sub-Saharan Africa: Next-Generation Strategies Amid Changing HIV Epidemiology

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases

ORG_CITY: MADISON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative: Antibiotic resistant infections pose a public health crisis requiring new approaches to antibiotic development. In this proposal we will develop and apply genome scale screens to identify virulence factors that can serve as novel antibiotic targets in the human and animal pathogen Listeria monocytogenes. Upon completion of these aims we will have a high value target list for novel antibiotic discovery, will have defined novel virulence factor functions in immune evasion and will have identified potential synergies between antibiotic therapies and protective immune responses.

PI_NAMEs: SAUER, JOHN-DEMIAN  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Animal Model;Animals;anti-microbial peptide;antibiotic resistant infections;Antibiotic Therapy;Antibiotics;antimicrobial;Antimicrobial Resistance;Biological Models;Bone Marrow;Cell Culture Techniques;Cells;Cellular biology;Cessation of life;combat;Combined Modality Therapy;Complex;cytokine;Development;Disease;emerging antibiotic resistance;Essential Genes;experimental study;Fertility;foodborne pathogen;Future;gene function;Gene Modified;Genes;Genetic;genetic manipulation;Genome;genome-wide;global health;Host Defense;Human;Immune;immune activation;Immune Evasion;Immune response;Immune signaling;Immune system;In Vitro;in vivo;Incidence;Infection;infectious disease model;Inflammasome;Innate Immune System;Intervention;Invaded;Larva;lead candidate;Libraries;Listeria monocytogenes;Listeriosis;Livestock;Macrophage;Mediating;Microbial Physiology;Modeling;mutant;Natural Immunity;Nature;novel;novel strategies;Nutritional Immunity;Organism;Oxidases;pathogen;Pathogenesis;Pathway interactions;Persons;Phagocytes;Phagosomes;Poverty;pressure;Production;Proteins;Public Health;Reactive Oxygen Species;Reporting;Resistance;Resistance development;screening;Signal Pathway;Signal Transduction;small molecule inhibitor;Study models;synergism;tool;Transgenic Organisms;transposon sequencing;Validation;Virulence;Virulence Factors;virulence gene;whole genome;Work;Zebrafish;Zoonoses

PROJECT_TITLE: Identification of Listeria monocytogenes immune evasion mechanisms

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Aging;Biotechnology;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Pediatric;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Non-human primates are excellent models of the human immune system, and previous pre-clinical studies in adult rhesus macaques have directly informed the choice of vaccine route, schedule and/or adjuvant for clinical assessment of malaria vaccine candidates. However, despite infants and children being the target population for malaria vaccines, no infant non-human primate malaria challenge model currently exists for vaccine evaluation. This project will develop a novel infant rhesus malaria challenge model and use this model to define how age at immunization and features of the developing infant immune system shape the response to malaria vaccination.

PI_NAMEs: SHEARS, MELANIE JANET (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Acceleration;Adjuvant;Adult;Age;age difference;age effect;age group;age related changes;Animals;Antibodies;Antibody titer measurement;Attenuated;Autopsy;B-Lymphocytes;Blood;cell killing;Cell Physiology;Cells;Cessation of life;Characteristics;Child;Childhood;Clinical assessments;Clinical Trials;cohort;Communicable Diseases;Cytotoxic T-Lymphocytes;Data;Development;diagnostic assay;Disease;Dose;Enrollment;Human;human model;Immune;Immune response;Immune system;Immune Tolerance;Immunity;Immunization;immunogenicity;Immunological Models;Immunologics;Individual;Infant;infant infection;Infection;Intravenous;Licensing;life span;Liver;liver biopsy;Macaca mulatta;Malaria;malaria infection;malaria transmission;Malaria Vaccines;mature animal;Modeling;Morbidity - disease rate;mortality;Nature;nonhuman primate;novel;Older Population;Parasites;Peripheral;peripheral blood;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Phenotype;Plasma;Plasmodium;Plasmodium falciparum vaccine;Plasmodium knowlesi;Population;preclinical study;Research;Research Design;response;Reverse Transcriptase Polymerase Chain Reaction;Rhesus;Ribosomal RNA;Route;Sampling;Schedule;Shapes;Sporozoite vaccine;Sporozoites;Subunit Vaccines;Symptoms;System;Systems Development;T cell response;T-Lymphocyte;Target Populations;Testing;Tissues;transmission process;trend;Vaccination;vaccination outcome;vaccine candidate;Vaccine Clinical Trial;vaccine development;vaccine efficacy;vaccine evaluation;vaccine immunogenicity;vaccine response;vaccine strategy;vaccine trial;Vaccines;young adult

PROJECT_TITLE: Malaria vaccine evaluation in a novel infant NHP challenge model

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases

ORG_CITY: OMAHA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE Coxiella burnetii is an obligate intracellular pathogen that causes human Q fever. We propose to elucidate Coxiella’s strategies to manipulate host lipid metabolism by regulating inter-organelle interactions in the host cell. Completion of this study will greatly advance our understanding on Coxiella subverts host cell processes, which could reveal potential therapeutic targets for Q fever treatment.

PI_NAMEs: GILK, STACEY D (contact)

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: Acute;Address;Antibiotic Therapy;Antibiotics;Bacteria;Bacterial Infections;Bacterial Proteins;Binding;Binding Proteins;Bioinformatics;Biological Assay;Cell Physiology;Cells;Cessation of life;Cholesterol;Cholesterol Homeostasis;Chronic;chronic infection;Complement;Coxiella;Coxiella burnetii;Data;Development;Disease Outbreaks;Ectopic Expression;Endocarditis;Endoplasmic Reticulum;Etiology;Eukaryotic Cell;experimental study;Family;Family member;Fatigue;flu;Fluorescence;Funding;Future;Genetic Complementation Test;Growth;Health;Homeostasis;Human;Immune response;Individual;Infection;insight;lipid metabolism;Lipids;Location;Macrophage;Maintenance;Measures;Mediating;member;Membrane;Modeling;Molecular;Molecular Structure;Molecular Target;mutant;Netherlands;novel;Organelles;pathogen;Pathogenesis;Patient Noncompliance;Phagolysosome;Play;Protein Family;Protein Secretion;Proteins;Publishing;Q Fever;Regimen;Research;Role;Site;Symptoms;System;Testing;Therapeutic Intervention;therapeutic target;Vacuole;Virulence Factors;yeast two hybrid system

PROJECT_TITLE: Coxiella secreted proteins mediating inter-organelle membrane contact sites


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness;Women's Health Research

ORG_CITY: Nashville

ORG_DEPT: PSYCHOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Postpartum depression is prevalent and associated with profound negative effects on mothers and their offspring, making the need to better understand risk processes and inform prevention efforts urgent. We will conduct multimethod intensive longitudinal assessments across the peripartum period to examine trajectories of positive valence systems (PVS) function, examine whether PVS influence mother–infant interactions, and explore neurobiological and psychosocial PVS processes shaping risk for postpartum depression. This study will have relevance for understanding the dynamic interplay of factors shaping positive valence systems and depression risk, with implications for determining when and how to intervene to prevent postpartum depression.

PI_NAMEs: KUJAWA, AUTUMN J (contact)

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Acute;acute stress;Affect;Automobile Driving;Birth;Birth trauma;Brain;Classification;Complex;Conceptions;critical period;depressive symptoms;Desire for food;Diagnosis;Disparate;Distress;Drops;Ecological momentary assessment;Electroencephalography;Enrollment;experience;Face;follow up assessment;Hair;Happiness;Health;high risk;Hormones;Hydrocortisone;Infant;innovation;insight;Intercept;Intervention;Interview;Life;Longitudinal Studies;Measures;Mental Depression;Methods;Mothers;Motivation;National Institute of Mental Health;negative affect;Negative Valence;neural;Neurobiology;Neurosciences Research;offspring;Outcome;Patient Self-Report;Perinatal;Personal Satisfaction;Persons;Play;pleasure;Positive Valence;Postpartum Depression;Postpartum Period;Pregnancy;pregnant;Pregnant Women;prevent;Prevention;Process;prospective;psychosocial;Psychosocial Factor;Psychosocial Stress;psychosocial stressors;Questionnaires;recruit;Research;Research Domain Criteria;Research Methodology;Research Support;response;Rewards;Risk;Risk Factors;Role;Sampling;Second Pregnancy Trimester;Shapes;social;Stimulus;Stress;stressor;Symptoms;System;Testing;Time;Treatment/Psychosocial Effects;virtual assessment

PROJECT_TITLE: Trajectories of Positive Valence Systems Function and Postpartum Depression Risk

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Cardiovascular;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Prevention;Serious Mental Illness;Social Determinants of Health;Substance Misuse;Suicide;Violence Research

ORG_CITY: RICHMOND

ORG_DEPT: PSYCHIATRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative This project seeks to clarify the mechanisms by which alcohol use disorder is related to risk of suicidal behavior, namely through psychiatric illness, medical comorbidity, and aggregate genetic liability. We will apply a range of novel and sophisticated methodological approaches using data from Swedish national registries. Given close parallels between alcohol use disorder and suicidal behavior across Sweden and the US, these findings have the potential to improve risk assessment, prevention, and intervention.

PI_NAMEs: EDWARDS, ALEXIS C (contact);SUNDQUIST, KRISTINA

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Accidents;Accounting;Address;Age;Alcohol consumption;alcohol use disorder;Atrial Fibrillation;Attenuated;Autopsy;Award;Cardiovascular Diseases;causal model;Censuses;Cessation of life;Characteristics;Collaborations;comorbidity;Complement;Data;data registry;Data Set;Dementia;Development;disability-adjusted life years;disorder subtype;Divorce;Economics;Education;Environmental Risk Factor;epidemiological model;Ethnic Origin;Etiology;Exhibits;experience;Family;family genetics;Family member;Funding;Genetic;genetic epidemiology;Genetic Models;Genetic Risk;Goals;health care service utilization;Healthcare;Heart failure;high risk;improved;Individual;Injury;Inpatients;Interpersonal Violence;Intervention;Job loss;Knowledge;Life Cycle Stages;Link;Major Depressive Disorder;Marital Status;Measures;Mediating;Mediation;Medical;Medical History;medical specialties;men;Mental disorders;Methodology;Methods;model design;Modeling;Molecular Genetics;molecular scale;Mood Disorders;mortality;Myocardial Ischemia;novel;Outcome;Outpatients;Pain;Pathway interactions;Persons;Population;Population Heterogeneity;Post-Traumatic Stress Disorders;Prevention;preventive intervention;Primary Care;Productivity;psychiatric comorbidity;psychologic;Psychopathology;Public Health;Recording of previous events;Registries;Relative Risks;Reporting;Research;Resources;Risk;Risk Assessment;Risk Behaviors;Risk Factors;Role;sex;Sex Differences;social deficits;social model;socioeconomics;Stroke;Subgroup;Substance abuse problem;Substance Use Disorder;suicidal behavior;suicidal morbidity;suicidal risk;Suicide attempt;suicide rate;Sweden;Testing;Time;trauma exposure;Work

PROJECT_TITLE: The Etiology of Risk: Alcohol Use Disorder and Suicidal Behavior

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: NASHVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: PROJECT NARRATIVE More than 2.7 million military service members have deployed to Iraq or Afghanistan since 2001. Compared to non-deployed personnel, Veterans of these conflicts have a higher prevalence of exertional dyspnea and other respiratory symptoms which may relate to exposure to inhalational irritants during deployment. While many such Veterans are ultimately diagnosed with common respiratory diseases, constrictive bronchiolitis (CB) has been reported in up 78% of Veterans with unexplained dyspnea who undergo surgical lung biopsy. In this study, we will determine long-term outcomes in Veterans with deployment-related constrictive bronchiolitis (DR-CB), investigate specific metals which drive ongoing activation of the immune system and lung damage, and rigorously assess cutting-edge diagnostic modalities which may improve our ability to diagnose DR-CB non-invasively.

PI_NAMEs: RICHMOND, BRADLEY WINSTON (contact)

PROJECT_TERMS: adaptive immunity;Affect;Afghanistan;Age;airway obstruction;Area;Asthma;attenuation;biobank;biomarker identification;Biopsy;Breathing;Bronchiolitis;burn pit;Case Series;Cells;Chronic;Clinical;clinical phenotype;Clinical Trials;cohort;Collection;combat;cost;Data;Deposition;detection method;Development;Diagnosis;Diagnostic;diagnostic criteria;Disease;Disease Progression;dust storms;Dyspnea;Elements;Evaluation;Evolution;Exertion;expiration;Exposure to;follow-up;Follow-Up Studies;former smoker;Future;Gender;Gene Expression;High Prevalence;high risk;Human Resources;Image;Immune;immune activation;Immune response;Immune system;improved;Industrialization;Inflammatory;Infrastructure;Inhalation;Injury;Iraq;Irritants;Journals;Lead;Lesion;Link;Lung;Lung Diseases;lung injury;Maps;Mass Spectrum Analysis;Measurement;Medicine;Metals;Methods;military service;Modality;Modeling;Monitor;Morbidity - disease rate;mortality;New England;non-smoker;non-smoking;noninvasive diagnosis;Operative Surgical Procedures;Outcome;Pathogenesis;Patient Self-Report;Patients;Pattern;Pleura;Pleural Diseases;Pollution;Prospective, cohort study;Publishing;Pulmonary Heart Disease;Pulmonary Pathology;Questionnaires;Radiology Specialty;Recording of previous events;Reporting;respiratory;Respiratory Disease;Respiratory Signs and Symptoms;response;Roentgen Rays;Scanning;service member;Silicon;small airways disease;Smoke;Smoking;Stimulus;Strontium;Structure of parenchyma of lung;Surrogate Endpoint;Symptoms;Syndrome;Techniques;Testing;Tissue Sample;Tissues;Titanium;Trace Elements;transcriptomics;Vascular Diseases;Velocimetries;Veterans;X-Ray Computed Tomography

PROJECT_TITLE: Post-Deployment Respiratory Syndrome in Veterans of Iraq and Afghanistan

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 MERP-B (01)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Maternal Health;Maternal Morbidity and Mortality;Patient Safety;Pediatric;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: KANSAS CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MISSOURI KANSAS CITY

ORG_STATE: MO

PHR: Project Narrative for HOPE study: Women with cardiovascular disease (CVD) have the highest risk of adverse maternal and neonatal outcomes and in the US, which has the worst maternal outcomes and greatest racial disparities in the industrial world, there is a lack of evidence estimating patients’ risks or how best to structure Cardio-Obstetrics (COB) care. The HOPE study has coalesced the nation’s top COB experts to prospectively enroll 1000 pregnant women with CVD to identify patient risk factors for adverse clinical and quality of life outcomes, and to rigorously test what structures and processes of care best optimize outcomes. Through our dissemination partners and engagement with professional organizations and patient-advocacy groups, we will develop novel strategies to elevate the care of pregnant people with CVD and reduce disparities by defining the optimal structures of COB care, guiding the development of performance measures for quality, and by supporting the creation of novel risk prediction models to support the creation of risk-based protocols to optimize outcomes.

PI_NAMEs: FLORIO, KAREN L;SPERTUS, JOHN A (contact)

PROGRAM_OFFICER_NAME: PEMBERTON, VICTORIA

PROJECT_TERMS: Acceleration;Address;Adopted;adverse maternal outcomes;adverse outcome;adverse pregnancy outcome;Affect;Ambulatory Care;American College of Obstetricians and Gynecologists;American Heart Association;Anesthesia procedures;Black race;black women;Body System;Cardiac;Cardiology;Cardiovascular Diseases;Cardiovascular Pregnancy Complications;care coordination;care delivery;Caring;Case Report Form;Cause of Death;Cessation of life;Characteristics;Clinic;Clinical;clinical care;clinical practice;Clinical Trials;Collaborations;comorbidity;Conceptions;Country;Critical Care;Data;Data Collection;Death Rate;design;Developed Countries;Development;Discipline of obstetrics;Disease;disease disparity;Disparity;disparity reduction;Elements;Enrollment;Evaluation;Event;expectation;experience;Foundations;Future;hazard;Health Status;Heart;Heart Diseases;High Prevalence;high risk;Hospitals;improved;improved outcome;Industrialization;infant outcome;inpatient service;insight;Investigation;low and middle-income countries;maternal morbidity;Maternal Mortality;maternal outcome;Maternal-fetal medicine;Measures;Minority;Missouri;Modeling;multidisciplinary;Neonatal;neonatal outcome;novel;novel strategies;obstetric care;Outcome;outcome disparities;Participant;patient advocacy group;Patient Outcomes Assessments;Patient risk;Patients;Patterns of Care;perceived discrimination;Performance;Persons;Phase;Pilot Projects;Population;Postnatal Care;Postpartum Period;Pre-Eclampsia;Pregnancy;Pregnancy Outcome;pregnancy related death;pregnant;Pregnant Women;prenatal;Prenatal care;Preparation;Process;Professional Organizations;programs;prospective;Prospective Studies;Protocols documentation;Quality of life;Quality of Life Assessment;racial difference;racial disparity;Recommendation;Reporting;Review Committee;Risk;Risk Factors;risk prediction model;risk stratification;Severity of illness;Site;socioeconomics;Specialist;Structure;Symptoms;Testing;Time;Translations;trend;Woman;Work

PROJECT_TITLE: The Heart Outcomes for Pregnancy Expectations Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-X (02)]


ADMINISTERING_IC: HD

ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Princeton

ORG_DEPT: MISCELLANEOUS

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: THE FRAGILE FAMILIES AND CHILD WELLBEING STUDY – YOUNG ADULTHOOD Project Narrative The Fragile Families and Child Wellbeing Study is the US’s longest-running contemporary national birth cohort study and, with age 27 data, will allow researchers to examine how experiences and exposures across childhood, adolescence, and early adulthood influence health and wellbeing in young adulthood. The sample is very diverse, allowing researchers to examine racial, ethnic, and socioeconomic disparities in health and wellbeing. Further, the multigenerational nature of the study will allow researchers to examine intergenerational mobility and persistence of a wide range of health and wellbeing outcomes.

PI_NAMEs: EDIN, KATHRYN  (contact);WALDFOGEL, JANE

PROGRAM_OFFICER_NAME: JEKIELEK, SUSAN

PROJECT_TERMS: Adolescence;Adolescent;Age;Area;Authorization documentation;Behavior;Birth;Black race;Book Chapters;Books;Child;child bearing;Child Welfare;Childhood;Cities;Cohort Studies;contextual factors;COVID-19 pandemic;COVID-19 pandemic effects;Criminal Justice;Data;Disadvantaged;economic disparity;Economics;Education;emerging adult;Employment;Environment;Environmental Risk Factor;Ethnic Origin;experience;Exposure to;Family;Family Relationship;Fathers;follow-up;Funding;gene environment interaction;Health;health disparity;Health Insurance;Hispanic;Housing;Income;innovation;insight;intergenerational;Interview;Interviewer;journal article;Life Cycle Stages;life span;Marketing;Mental Health;Mothers;multi-racial;Nature;Neighborhoods;Online Systems;Outcome;pandemic disease;Paper;Parents;Patient Self-Report;Personal Satisfaction;Persons;physical conditioning;Physical environment;Police;Policies;Population;Poverty;primary caregiver;Probability Samples;programs;Publications;Race;racial disparity;Records;Request for Proposals;Research;Research Design;Research Personnel;Resource Sharing;Resources;Running;saliva sample;Sampling;social;Social Work;socioeconomic disparity;Socioeconomic Status;Surveys;System;Telephone;Testing;Training;Unmarried;young adult;Youth

PROJECT_TITLE: Fragile Families and Child Wellbeing - Young Adulthood

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

ORG_STATE: MA

PHR: There are 650,000 invasive non-surgical interventional cardiology, interventional radiology and gastrointestinal endoscopy procedures performed annually resulting in 22,000 emergency department visits and 25,500 admissions. Adverse events may cause up half of this post-procedure utilization and are poorly understood; presently, there is no patient safety surveillance in the VA for invasive procedures. This IIR proposal addresses the VA's urgent need for targeted surveillance tools to detect adverse events and inform quality improvement initiatives at the facility and specialty levels. The proposed work will test two hypothesized opportunities to update care guidelines or design quality initiatives to mitigate patient harm using surveillance data: whether the patient received inappropriate antibiotics and whether an anesthesiologist was involved in the procedure. We will also examine disparities in care processes in each specialty. Surveillance data will inform policy directives by operational partners from each specialty as well as Pharmacy Benefits Management.

PI_NAMEs: MULL, HILLARY JANE (contact)

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;Adherence;Admission activity;Adverse event;adverse event monitoring;adverse outcome;Ambulatory Surgical Procedures;Anesthesia procedures;Antibiotics;Area;Big Data;Cardiology;career;Caring;case-based;Cessation of life;Characteristics;Clinic;Clinical;clinical care;Clostridium difficile;Communities;Country;Data;data mining;Data Set;data warehouse;Databases;design;Detection;Devices;Disparity;Doctor of Philosophy;Emergency department visit;Evaluation;Event;experience;Fostering;Frequencies;Frontline worker;Funding;Gastroenterology;Gastrointestinal Endoscopy;Guidelines;health care disparity;health care service utilization;Health Services Research;Healthcare;Homogeneously Staining Region;Hospitalization;improved;Infection;Informatics;informatics tool;Infrastructure;Injections;innovation;Intervention;Interventional radiology;Investigator-Initiated Research;K-Series Research Career Programs;Link;Literature;Logistic Regressions;Measures;Medical Informatics;medical specialties;Methodology;Methods;Modeling;neglect;novel;Operating Rooms;Operative Surgical Procedures;Patient Care;patient safety;Patient-Focused Outcomes;Patients;Performance;Pharmaceutical Preparations;pharmacy benefit;Policies;predictive modeling;Predictive Value;prevent;Probability;Procedures;Process;Provider;racial disparity;Radiology Specialty;Research;Research Personnel;Research Project Grants;respiratory;Risk Adjustment;Risk Factors;safe patient;Sampling;Site;Sterility;Structure;structured data;Surgical incisions;surveillance data;Surveillance Modeling;System;Testing;Text;tool;Training;Update;Variant;Work;wound

PROJECT_TITLE: How Can We Make Invasive Non-Surgical Procedures Safer? Using Big Data to Identify Adverse Events and Opportunities to Mitigate Harm

STUDY_SECTION_NAME: HSR-3 Healthcare Informatics[HSR3]


PHR: Surgical site infections are common and morbid; however, they are preventable with administration of evidence- based antimicrobial prophylaxis. In 2005, in the setting of high rates of non-compliance with antimicrobial prophylaxis guidelines, the VA implemented the Surgical Care Improvement Project (SCIP). SCIP included public reporting of evidenced-based antimicrobial guideline compliance metrics in high-risk surgeries and led to high rates of adoption of evidence-based practices (>95%). The program was retired in 2015, as the manual measurement and reporting process was costly with limited expected additional benefit. This IIR will use novel electronic algorithms to measure compliance with SCIP metrics over time, and stakeholder feedback to identify intervention strategies to sustain compliance. The aims are guided by the Dynamic Sustainability Framework and will address 1) the sustainability and spread of practice changes achieved by SCIP, 2) factors influencing sustainability, and 3) implementation strategies to test in a future Hybrid III trial to improve compliance.

PI_NAMEs: BRANCH-ELLIMAN, WESTYN ;MULL, HILLARY JANE (contact)

PROJECT_TERMS: Accounting;Acute Renal Failure with Renal Papillary Necrosis;Address;Adopted;Adoption;Adverse event;adverse outcome;Algorithms;Ambulatory Surgical Procedures;antimicrobial;Antimicrobial Resistance;Area;Assessment tool;Blood Vessels;Bypass;Cardiac;Caring;Cessation of life;Clinical;clinical care;Clostridium difficile;Colorectal;contextual factors;cost;Data;data mining;design;Doctor of Philosophy;Documentation;Drops;Educational Curriculum;effectiveness/implementation study;electronic data;Electronic Health Record;Electronics;Elements;evidence base;evidence based guidelines;Evidence based practice;Exclusion;Feedback;Frontline worker;Funding;Future;Goals;Guidelines;Gynecology;Health system;Healthcare;healthcare-associated infections;high risk;Hybrids;implementation barriers;implementation science;implementation strategy;improved;Infection;Informatics;informatics tool;innovation;Interruption;Intervention;Interview;Learning;Manuals;Maps;Measurement;Measures;medical specialties;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;non-compliance;novel;Operative Surgical Procedures;Orthopedics;Outpatients;Patients;Peer Review;Performance;Perioperative;Pharmacy facility;Policies;Postoperative Period;Prevention Measures;Procedures;Process;Program Reviews;programs;Prophylactic treatment;Provider;Recommendation;Replacement Arthroplasty;Reporting;Research;Resources;Retirement;Sampling;scale up;Structure;structured data;surgery outcome;Surgical incisions;surgical risk;Surgical Specialties;Surgical Wound Infection;sustainability framework;Technology;Testing;Text;Time;Time Series Analysis;tool;Training;Translational Research;voltage;Work

PROJECT_TITLE: Assessing the Sustainability of Compliance with Surgical Site Infection Prophylaxis After Discontinuation of Mandatory Active Reporting


NIH_SPENDING_CATS: Autism;Brain Disorders;Depression;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: Aurora

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Narrative Early developmental exposure to antidepressants such as selective serotonin reuptake inhibitors (SSRIs) has been associated with an increased incidence of ASDs in offspring. Determining how serotonin signals in the developing brain is a key first step to understanding how SSRIs alter serotonin system and may cause ASDs. A better understanding about the central roles of serotonin signaling in brain function will be significant and has the potential to direct new therapeutic strategies for neurodevelopmental disorders involving serotonin dysregulation, such as ASDs.

PI_NAMEs: OH, WON CHAN  (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Age;Agreement;Animal Model;anti-depressive agents;autism spectrum disorder;autism symptoms;Behavior;Behavioral;Blood;Brain;Brain Diseases;Calcium;Calcium Signaling;cell type;Cerebral cortex;Chronic;cognitive process;Color;Communication;Data;Dendrites;Dendritic Spines;density;Development;Disease;Electrophysiology (science);Environmental Risk Factor;Excitatory Synapse;experience;experimental study;Exposure to;fetal;fluorescence lifetime imaging;Fluoxetine;Functional disorder;gamma-Aminobutyric Acid;Genetic;Glutamates;Goals;Growth;hippocampal pyramidal neuron;Human;Image;Impairment;improved;Incidence;Individual;infancy;insight;Interneurons;Invaded;Investigation;Knowledge;Life;Literature;Localized Lesion;Measures;Mediating;Molecular;Mus;neonatal exposure;neural circuit;Neurodevelopmental Disorder;Neuronal Dysfunction;neuronal excitability;Neurons;Neurotransmitters;novel;novel therapeutic intervention;offspring;optogenetics;Outcome;Pathogenesis;Pathology;Pharmaceutical Preparations;pharmacologic;Physiological;postnatal;postsynaptic;Prefrontal Cortex;Pregnancy;Pregnant Women;prenatal exposure;Presynaptic Terminals;psychologic;receptor;Receptor Activation;Receptor Signaling;Research;Resolution;response;Risk;Role;Selective Serotonin Reuptake Inhibitor;Serotonergic System;Serotonin;Signal Transduction;Site;social;social deficits;Somatostatin;spatiotemporal;Stimulus;Symptoms;Synapses;synaptic function;synaptogenesis;Testing;Time;tool;two-photon;Vertebral column;Work

PROJECT_TITLE: Serotonergic modulation of excitatory synapse formation and maturation during development

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS-R]


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: EAST LANSING

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project narrative This grant proposes an innovative contrast agent - TaOx nanoparticles – and an X-ray computed tomography method for imaging implantable biomaterials, in vivo. Our goals here are to determine 1) the in vitro and in vivo biological effects of these new contrast agent and 2) the effectiveness of the imaging methodology to measure in vivo biodegradation of implantable biomaterials. Successful demonstrations will rationalize continuing translational studies towards in vivo CT evaluation of TaOx- embedded TES in humans.

PI_NAMEs: SHAPIRO, ERIK  (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: 3-Dimensional;Academia;axon growth;Bilateral;Biocompatible Materials;biodegradable polymer;Biodegradation;Biological;Biological Assay;biomaterial compatibility;Bismuth;bone;Carrageenan;Cells;Clinical;clinical translation;Collection;Connective Tissue;contrast imaging;Contrast Media;Coupled;Data;Data Analyses;design;Development;Effectiveness;Environment;Evaluation;Exhibits;Gadolinium;Glycolates;Goals;Grant;Greater sac of peritoneum;Growth;high resolution imaging;Histology;Hospitals;Human;Image;imaging modality;imaging system;Immune;Implant;implantation;In Vitro;in vivo;Industry;Inflammation;innovation;Knowledge;Length;Limb structure;Location;Measurement;Measures;Mechanics;Methodology;microCT;Microscopy;Modeling;Monitor;Mus;nanoparticle;Nerve;Nerve Regeneration;neural;Optics;Outcome;outer space;Pathology;Patients;Performance;Peripheral nerve injury;physical property;Physiological;Physiology;polycaprolactone;Polymers;Porosity;pre-clinical;Property;Protocols documentation;Radiation;Radiology Specialty;Rationalization;Rattus;reconstruction;Regenerative Medicine;research and development;Resolution;Roentgen Rays;scaffold;Scanning;sciatic nerve injury;serial imaging;Site;Skin;Spinal nerve structure;Structure;subcutaneous;System;systems research;tantalum oxide;Techniques;Tensile Strength;Testing;Tissue Embedding;Tissue Engineering;tissue regeneration;Tissues;Toxic effect;Toxicology;translation to humans;translational study;Tube;Visualization;X-Ray Computed Tomography

PROJECT_TITLE: Evaluation of tantalum oxide nanoparticles for in vivo X-ray computed tomography evaluation of implantable biomaterials

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Climate-Related Exposures and Conditions;Estrogen;Immunotherapy;Skin Cancer

ORG_CITY: Columbus

ORG_DEPT: GENETICS

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE Epidemiological studies and clinical data correlate decreased estrogen signaling and loss of estrogen receptor beta (ERβ) expression to increased melanoma risk and disease progression. This proposal will determine how estrogen signaling through ERβ regulates melanocyte biology, impacts immune recognition of the tumor, and protects against melanoma. As an integral part of these studies, we propose to evaluate the potential of ERβ- specific agonists in enhancing current melanoma therapies.

PI_NAMEs: BURD, CRAIG J (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Acceleration;Agonist;Binding;Bioinformatics;Biology;Cell Culture System;Cell Differentiation process;cell motility;Cells;checkpoint therapy;ChIP-seq;Clinical;Clinical Data;Clinical Research;Correlation Studies;cytokine;Data;Data Correlations;Diagnosis;Disease;Disease Progression;epidemiology study;Estrogen decline;Estrogen Receptor 2;Estrogens;Exhibits;Experimental Models;Exposure to;Genes;Genetic;Genetic Transcription;Goals;Gonadal Steroid Hormones;hormonal signals;hormone therapy;Hormones;Human;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune response;Immune system;Immunologics;Immunotherapy;improved;In Vitro;Infiltration;Inflammatory;Knock-out;Knockout Mice;Lead;Link;Lymphocyte;Malignant Neoplasms;Mediating;melanocyte;Melanoma;Melanoma Tumor;melanomagenesis;men;Menopause;Metastatic Melanoma;migration;Modeling;Molecular;Motility;mouse model;Mus;Oncogenes;Outcome;Pathway interactions;pharmacologic;Play;Population;Production;Proliferating;receptor;Regulation;Repression;response;Risk;Role;Signal Transduction;Skin Cancer;T cell infiltration;T-Cell Activation;Testing;transcription factor;transcriptome;treatment response;tumor;tumor initiation;Tumor Suppressor Proteins;ultraviolet;ultraviolet damage;Woman;Work

PROJECT_TITLE: Estrogen receptor beta is a targetable melanoma tumor suppressor

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Liver Cancer;Liver Disease;Primary Health Care;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: PALO ALTO

ORG_NAME: PALO ALTO VETERANS INSTIT FOR RESEARCH

ORG_STATE: CA

PHR: PROJECT NARRATIVE While implementing effective cancer screening programs for hepatocellular carcinoma (HCC) among individuals with cirrhosis leads to early tumor detection, improved treatment options, and improved survival, ethnic minorities and non-English speaking immigrant populations consistently have disparately lower rates of receiving HCC screening. Our novel research aims to incorporate a comprehensive assessment of patient-level, provider-level, and system-level factors to understand the mechanistic drivers of these disparities among ethnic minority and immigrant populations. Our analyses will identify a core set of modifiable factors across patient, provider, and system levels that can be used to design a future multi-level intervention to improve rates of HCC screening among ethnic minorities and vulnerable immigrant populations in the U.S. leading to better treatment and improved survival.

PI_NAMEs: WONG, ROBERT JOHN (contact)

PROGRAM_OFFICER_NAME: WHITE, DOLLY PENN

PROJECT_TERMS: Abdomen;Acute;Adherence;Affect;Alcohol abuse;alcohol use disorder;analytical method;Attitude;Cancer Etiology;care delivery;Caring;Cessation of life;chronic liver disease;Cirrhosis;Clinic;Clinical;Clinical Trials;cohort;Collaborations;Community Health Networks;comorbidity;Complex;COVID-19;COVID-19 pandemic;COVID-19 pandemic effects;COVID-19 susceptibility;Data;design;Detection;Deterioration;Development;Diagnostic Services;Disparate;Disparity;disparity reduction;Drug usage;Educational Status;Electronic Health Record;ethnic disparity;ethnic diversity;ethnic minority;ethnic minority population;Familiarity;follow-up;Future;Gastroenterology;General Hospitals;Geography;Goals;Guidelines;Health;health care delivery;health care service;Health Services Accessibility;Health system;High Prevalence;high risk;high risk behavior;Hospitals;Household;Immigrant;improved;Income;Individual;innovation;Intervention;Knowledge;Laboratories;Link;Liver Cirrhosis;Liver diseases;liver function;Long-Term Effects;low socioeconomic status;Mediating;Mediation;Methods;Monitor;Nature;novel;Outcome;pandemic disease;pandemic disruption;pandemic impact;pandemic response;Patients;Pattern;Persons;Phase;Population;post-COVID-19;Primary carcinoma of the liver cells;Primary Care;Process;prospective;Provider;provider factors;Quality of Care;racial disparity;Recovery;Research;response;Risk;Role;safety net;San Francisco;screening;screening disparities;Screening for cancer;screening program;Screening Result;screening services;Site;social vulnerability;socioeconomics;Stage at Diagnosis;Stereotyping;Structure;Substance Use Disorder;Surveys;synergism;System;system-level barriers;Techniques;Telemedicine;tumor;Tumor stage;ultrasound;Underinsured;Underserved Population;Vulnerable Populations

PROJECT_TITLE: Racial and Ethnic Disparities in Hepatocellular Carcinoma Surveillance Among Patients with Cirrhosis Across Five Safety Net Organizations

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Medical records are an integral method of communicating about patients and yet the language clinicians use to describe patients may reflect their own biases, be stigmatizing and adversely impact subsequent care. The specific aims of this proposal are to develop a taxonomy of stigmatizing language in medical records, to measure and test for bias in the use of stigmatizing language in medical records using natural language processing (NLP), and then to reduce stigmatizing language in medical records using proven implementation science (IS) strategies. Because language may have a powerful role in influencing subsequent clinician attitudes and behavior, this project could have a large impact on the promotion of respect and reduction of disparities for stigmatized groups.

PI_NAMEs: BEACH, MARY CATHERINE  (contact)

PROGRAM_OFFICER_NAME: OLADEINDE, YEWANDE A

PROJECT_TERMS: Affect;Age;Agreement;Algorithms;Area;Attention;Attitude;Behavior;Bypass;Canis familiaris;Caring;Categories;Clinical;Communication Methods;Computerized Patient Records;Consensus;Disparity;disparity reduction;Drug Prescriptions;Education;Equity;ethnic identity;Feedback;Focus Groups;Gender;Goals;health care quality;health literacy;Health Professional;Health system;Healthcare;Healthcare Systems;Impaired health;implementation science;implicit bias;improved;Individual;individual patient;Judgment;Language;low health literacy;Measures;Medical;Medical Records;medical specialties;Natural Language Processing;Obesity;older adult;oral communication;Pathway interactions;patient health information;Patients;Pattern;Persons;Physicians;pilot test;Politics;Punishment;Quality of Care;Race;racial disparity;Reading;Records;Role;sex;Sickle Cell Anemia;Social Class;Social status;Speech;Stereotyping;Stigmatization;substance abuser;Substance Use Disorder;Taxonomy;Testing;transmission process;Vision;Work;Writing

PROJECT_TITLE: Hidden in Plain Sight: Stigmatizing Language in Patient Medical Records

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-E(07)R]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Autism spectrum disorders (ASD) are highly debilitating neurodevelopmental disorders characterized by abnormal patterns of brain development. Our previous work has shown that mutations in the ASD risk gene SHANK3 in mice disrupt the normal maturation of corticostriatal circuits. This proposal will identify the mechanisms underlying the establishment of abnormal patterns of corticostriatal connectivity and determine their role in the onset of repetitive behaviors and social interaction abnormalities in these animals, providing important new insights into the pathogenesis of ASD.

PI_NAMEs: PEIXOTO, RUI  (contact)

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Animals;autism spectrum disorder;autistic;Behavior;Behavioral;Biological Models;Brain;Cells;Cognitive deficits;cohort;Corpus striatum structure;Cre driver;Cyclic AMP-Dependent Protein Kinases;Defect;Development;Disease;Environment;Exhibits;Functional disorder;Genetic;Genetic study;Glutamates;Growth;Hyperactivity;Hypertrophy;imaging study;Impairment;individuals with autism spectrum disorder;insight;Intervention;Knowledge;Label;Laboratories;Light;loss of function;maladaptive behavior;Molecular;motor deficit;Mus;Mutation;nerve supply;neural;Neurodevelopmental Disorder;Neurons;neuropathology;optogenetics;Pathogenesis;Pathogenicity;Pathway interactions;Pattern;Peptides;Phase;Phenotype;Population;postnatal;postnatal development;postnatal period;Prefrontal Cortex;Process;protein expression;Protein Inhibition;Protein Kinase A Inhibitor;repetitive behavior;Reporter Genes;Reporting;response;Risk;risk variant;Role;social deficits;Social Interaction;synaptogenesis;targeted treatment;Testing;Therapeutic;Transgenic Mice;Transgenic Organisms;Viral;Wild Type Mouse;Work

PROJECT_TITLE: Mechanisms and pathogenic role of early corticostriatal dysfunction in Shank3B-/- mice


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Pediatric;Pregnancy;Prevention

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Child developmental and learning problems like ADHD, place heavy, often lifelong burdens on families, as well as on the nation's educational, health care, and justice systems. Early identification of risk and cause of ADHD would enable solutions to restore full child health and prevent onset of ADHD before problems become entrenched. This study will test key possibilities for early life prediction in areas that could be reversible with low-risk intervention.

PI_NAMEs: NIGG, JOEL T;SULLIVAN, ELINOR L. (contact)

PROGRAM_OFFICER_NAME: KING, ERIN MICHELE

PROJECT_TERMS: 3 year old;3-Dimensional;5 year old;Affect;Affective;Age;Age Months;Aggressive behavior;Algorithms;Anger;Area;Attention deficit hyperactivity disorder;Behavioral;behavioral outcome;Biological;Biological Markers;Birth;Brain;Breast Feeding;caregiving;Child;Child Health;Circulation;Clinical;clinical application;clinical candidate;clinical risk;Clinical Trials;Cognition;cohort;cost;Data;Depressed mood;Development;Developmental Process;early childhood;Early Diagnosis;Early identification;Early Intervention;Education;Electroencephalography;emotion dysregulation;emotion regulation;Emotional;Environmental Risk Factor;executive function;experimental study;family burden;fetal;Fetal Development;follow-up;Formulation;Fright;Functional disorder;Future;Genetic;Goals;Hand;Healthcare;Impairment;Impulsivity;inattention;indexing;Individual;Infant;Inflammation;Inflammatory;Intercept;interest;Intervention;Intervention Trial;Justice;Kynurenine;Learning;Life;Literature;Magnetic Resonance Imaging;Measurable;Measures;Mediating;Mental Health;Modeling;negative affect;neural;neurodevelopment;Nursery Schools;offspring;Outcome;Parents;Pathway interactions;Phenotype;Physiological;postnatal;Pregnancy;Pregnancy Trimesters;prenatal;Preschool Child;prevent;Program Development;prospective;Psychopathology;Regulation;Risk;Risk Factors;Risk Marker;risk prediction;Role;School-Age Population;Schools;Second Pregnancy Trimester;Serotonin;Shapes;Signal Transduction;Socialization;sound;Symptoms;System;systemic inflammatory response;teacher;Testing;Third Pregnancy Trimester;Time;Toddler;Tryptophan;Up-Regulation;Weather;Woman;Work

PROJECT_TITLE: Developmental origins and early detection of ADHD and dysregulatory psychopathology

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunotherapy;Palliative Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_DEPT: ADMINISTRATION

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative/Relevance This study will examine changes in the organization of oncology care providers over time and the impact of these changes on the quality of care, diffusion of new therapies, health care utilization, and outcomes for cancer patients overall and for vulnerable/disadvantaged subgroups. The findings will provide oncology practitioners, payers, and policy makers valuable information to improve access, quality and outcomes of cancer care. Our results also will inform policies and practices related to the value of integration of oncology care, quality measurement, design of alternative payment models, and development of innovative delivery models to care for vulnerable/disadvantaged populations.

PI_NAMEs: KEATING, NANCY L (contact);LANDRUM, MARY BETH

PROGRAM_OFFICER_NAME: WEAVER, SALLIE JAYNE

PROJECT_TERMS: Academy;acute care;American;Area;bundled payment;cancer care;Cancer Hospital;Cancer Patient;Capital;CAR T cell therapy;care coordination;care delivery;care providers;Caring;Clinical Data;Collaborations;Complex;Comprehensive Health Care;Country;Data;Data Set;Data Sources;Databases;design;Development;Diffusion;Disparity population;Enrollment;ethnic minority;evidence base;Expenditure;experience;Fee-for-Service Plans;Foundations;genetic testing;Genomics;Growth Factor;Guidelines;health care delivery;health care service utilization;health information technology;Health system;Healthcare Systems;hospice environment;hospital care;Hospitals;Immunotherapy;Improve Access;improved;Incentives;Individual;Infrastructure;innovation;Investments;Knowledge;Link;Malignant Neoplasms;Marketing;Measurement;Measures;Medicaid;Medicare;Medicine;Modeling;multiple chronic conditions;Neutropenia;novel;novel therapeutics;Oncology;Organizational Change;Outcome;Ownership;Palliative Care;participant enrollment;Patient Care;Patient Outcomes Assessments;patient population;Patients;payment;Performance;Pharmaceutical Preparations;Physicians;Policies;Policy Maker;Population;Poverty;Price;programs;Provider;Quality of Care;racial minority;Recommendation;Records;Regimen;Reporting;Risk;Rural;rural area;Source;survivorship;System;Systems Integration;targeted treatment;Taxes;Test Result;Testing;Time;trend;tumor;Underserved Population;United States Agency for Healthcare Research and Quality;United States Centers for Medicare and Medicaid Services;Variant;Vulnerable Populations

PROJECT_TITLE: The Impact of a Changing Health Care Delivery System on the Quality of Oncology Care

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: SAINT LOUIS

ORG_NAME: FIMBRION THERAPEUTICS, INC.

PHR: Project Narrative: Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis (Mtb), is a leading cause of human mortality in the world for a single infectious agent and drug-resistance to standard of care frontline and even second-line antibiotics is increasing, highlighting the need for new therapies. In this application, we propose to further develop a lead series of small molecule compounds for the treatment of TB, resulting in the selection of a clinical candidate to progress towards clinical trials. The proposed studies have the potential to result in the development of a new family of anti-mycobacterials to be used to treat both drug-sensitive and drug-resistant TB.

PI_NAMEs: HANNAN, THOMAS JOSEPH (contact)

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: Acute;Animal Model;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Antimicrobial Resistance;Antimycobacterial Agents;Antitubercular Antibiotics;Bacteria;bactericide;Biological;Biological Availability;Canis familiaris;Cells;Chronic;Clinical;clinical candidate;clinical development;Clinical Trials;clinically relevant;combat;Combination Drug Therapy;Combined Modality Therapy;commercial application;Complex;Cytochrome bc1 Complex;Cytochromes;Development;Disease;Drops;drug candidate;drug discovery;Drug Interactions;Drug Kinetics;Drug resistance;Drug resistance in tuberculosis;Drug resistant Mycobacteria Tuberculosis;Drug Targeting;drug-sensitive;druggable target;Electron Transport;Energy Metabolism;Exhibits;Explosion;Family;Funding;Goals;Half-Life;HepG2;Hour;human mortality;Hypoxia;improved;In Vitro;in vitro activity;in vivo;indexing;Industry;Infection;Infectious Agent;inhibitor;inhibitor therapy;Intellectual Property;interest;Intravenous;Lead;lead series;Licensing;Liver Microsomes;Lung infections;Macrophage;Mammals;Marketing;medication safety;Metabolic;Mission;Modeling;mortality;mouse model;Mus;Mycobacterium tuberculosis;nanomolar;Newly Diagnosed;non-tuberculosis mycobacteria;novel;novel drug class;novel therapeutics;Oral;Outcome;Oxidases;Patients;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Phase;phase 2 study;Phase II Clinical Trials;Plasma;pre-IND studies;Prevalence;Property;Proteins;Rattus;Regimen;Resistance;resistance mechanism;Resistance profile;resistant strain;Respiration;respiratory;Respiratory Chain;Risk;risk prediction;Safety;Series;Small Business Innovation Research Grant;small molecule;Solubility;Stains;standard of care;success;synergism;Testing;Therapeutic;therapeutic target;therapeutically effective;Time;Toxic effect;Tuberculosis;Tuberculosis diagnosis;tuberculosis drugs;tuberculosis treatment;United States National Institutes of Health;Work

PROJECT_TITLE: Heterocyclic Inhibitors of QcrB as Novel Drugs for Tuberculosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-C(14)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

ORG_CITY: WASHINGTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative The newly formed District of Columbia Clinical Trials Unit (DC CTU) is a regionally-focused CTU designed to address the HIV epidemic in the nation’s capital, one of the most severely affected areas in the United States. The DC CTU unites two experienced, high-impact clinical research sites and will conduct HIV prevention, treatment, and cure trials. In concert with the community, the DC CTU will contribute to trials that will eventually help end the HIV epidemic.

PI_NAMEs: HENN, SARAH ;MAGNUS, MANYA  (contact);SIEGEL, MARC OLIVER

PROGRAM_OFFICER_NAME: LANDIS, JESSICA R

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adult;Affect;African American population;AIDS clinical trial group;AIDS prevention;Area;Behavioral;Capital;Caring;Clinic;Clinical;clinical research site;Clinical Trials;Clinical Trials Network;Clinical Trials Unit;cohort;Communicable Diseases;Communities;community engaged approach;Conduct Clinical Trials;County;Data;data submission;design;Development;District of Columbia;Enrollment;Ensure;Epidemic;Epidemiologist;experience;Funding;Geography;Goals;Growth;Health;HIV;HIV prevention trials network;HIV/AIDS;Infrastructure;innovation;Institution;Laboratories;Leadership;Longitudinal Studies;Maryland;Medical;Mentors;Methods;Mission;Modeling;multidisciplinary;National Institute of Allergy and Infectious Disease;Participant;participant retention;participant safety;patient engagement;Performance;Persons;Pharmacy facility;Population;Prevalence;Prevention;recruit;Research;Research Personnel;Resources;retention rate;Risk;Sampling;Science;Services;Site;Therapeutic;Training;United States;United States National Institutes of Health;Universities;Washington

PROJECT_TITLE: The District of Columbia Clinical Trials Unit (DC CTU)


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: T lymphocytes, an important cellular component of protective and pathologic immune responses, require two signals to be activated. One, mediated by the T cell antigen receptor, ensures only specific responses occur, and the second, mediated by CD28, ensures that the T cell is responding to pathogens that have triggered awareness by the immune system. New results from different experimental approaches provide us with clues to gain a molecular understanding of how CD28 stimulates T cells which could lead to the design of better therapeutics to boost or control T cell responses.

PI_NAMEs: ZIKHERMAN, JULIE  (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Actins;Adhesions;Affect;Antigen-Presenting Cells;Antigens;Autoimmunity;Awareness;Biochemical;Biology;CD28 Antigens;CD28 gene;CD3 Antigens;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD80 gene;CD86 gene;CD8B1 gene;Cell Communication;Cell surface;Cells;Chemicals;Clinical;Collaborations;Cytoplasm;Cytoplasmic Tail;Cytoskeleton;Data;Dendritic Cells;design;Development;Elements;Ensure;filamin;Genetic;Hydrolysis;Immobilization;Immune response;Immune system;Infection;inhibitor;Innate Immune System;insight;intercellular cell adhesion molecule;Interleukin-2;Interruption;kinase inhibitor;Ligands;Malignant Neoplasms;Mature T-Lymphocyte;Mediating;Modeling;Molecular;Monoclonal Antibodies;Mus;mutant;Names;novel strategies;novel therapeutics;pathogen;Pathologic;Pathway interactions;Phosphatidylinositol 4,5-Diphosphate;Phospholipase;phosphoproteomics;Phosphorylation;Phosphotransferases;PIK3CG gene;PLC gamma1;polyproline;Production;Protein Tyrosine Kinase;Proteins;Proteomics;PTK2 gene;Recombinants;recruit;Regulation;response;rho GTP-Binding Proteins;Serine Phosphorylation Site;Signal Pathway;Signal Transduction;Site;small molecule inhibitor;src-Family Kinases;Superantigens;T cell response;T-Cell Activation;T-Cell Proliferation;T-Cell Receptor;T-Lymphocyte;Therapeutic;Threonine Phosphorylation Site;thymocyte;Transplantation;Tyrosine Phosphorylation;Tyrosine Phosphorylation Site

PROJECT_TITLE: The cell and molecular mechanisms underlying CD28 costimulation

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Aging;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Neurosciences;Pediatric;Post-Traumatic Stress Disorder (PTSD);Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

ORG_NAME: HOWARD UNIVERSITY

PHR: Project Narrative Social adversities such as poverty, harsh parenting, neighborhood disorganization, assaults, family instability, and parental incarceration are pervasive in inner-city, African American (AA) populations; and can have substantial impact on brain structure and function and other biological processes that put them at risk for chronic stress disorders and metabolic diseases. This proposal elucidates how intraneuronal noncoding RNA profiles associated with development of stress disorders following social adversities in childhood continue to influence biological processes (e.g. glucocorticoid receptor, GR, signaling) that make individuals more resilient or susceptible to current daily social adversities, such as racial discrimination, poverty and neighborhood disorder.

PI_NAMEs: NWULIA, EVARISTUS A (contact)

PROGRAM_OFFICER_NAME: BICKHAM-WRIGHT, UTIBE RONALD

PROJECT_TERMS: Ablation;Adult;Affect;African American;African American population;Amygdaloid structure;Animals;Arousal;assault;Base Sequence;Behavior;Behavioral;behavioral response;Binding;Biological;biological adaptation to stress;Biological Process;Biology;Brain;Buffers;C-reactive protein;Child Rearing;Childhood;childhood adversity;Chronic;Chronic Disease;Chronic stress;circadian;Circadian Dysregulation;circadian regulation;cohort;Confocal Microscopy;density;design;Development;developmental plasticity;Dimensions;Disease;Disparity;Distress;Environmental Exposure;Environmental Impact;Epigenetic Process;epigenomics;ethnic disparity;experience;Exposure to;Family;Genes;Genome;genome-wide;Glucocorticoid Receptor;Glucocorticoids;Growth;Health;heart rate variability;Hippocampus;Hydrocortisone;immune activation;Immune signaling;immunocytochemistry;Imprisonment;indexing;Individual;inner city;innovation;Intervention;life span;low socioeconomic status;Maternal Deprivation;Measures;Mediating;Mediation;Messenger RNA;Metabolic Diseases;MicroRNAs;Microscopy;Minority Groups;Modeling;Modification;Molecular;Morphology;nano;negative affect;Neighborhoods;Neurites;Neurons;neurophysiology;Neurosciences;novel;olfactory bulb;Pathway interactions;pediatric trauma;perceived discrimination;perceived stress;Physiological;Play;Populations at Risk;Post-Traumatic Stress Disorders;Poverty;Predisposition;prevent;Promoter Regions;prospective;Prospective Studies;racial discrimination;racial disparity;Reflex action;resilience;resilience biomarker;Resolution;response;Response Elements;Reverse Transcriptase Polymerase Chain Reaction;Risk;Risk Taking;Role;Salivary;Sampling;Severities;Signal Transduction;Sleep;Sleep disturbances;social;social adversity;Social Discrimination;social disparities;Social Environment;social stress;Social support;Spirituality;Stress;stress disorder;Structure;Translating;trauma exposure;ultra high resolution;Untranslated RNA;Variant;young adult

PROJECT_TITLE: Elucidating Olfactory-Based Epigenetic Mediation of Social Contexts on Stress Response Across Life Span in Low SES Inner-City Minority Populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-F(55)R]


NIH_SPENDING_CATS: Bipolar Disorder;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

PHR: PROJECT NARRATIVE. Bipolar Disorder (BD) is defined by a history of hypo/mania, and is common and highly debilitating; yet, the brain mechanisms predisposing to hypo/mania are poorly understood. Previously, we have shown that adults with BD have abnormally elevated left ventrolateral prefrontal cortex (vlPFC) activity during reward anticipation, and that elevated left vlPFC activity was associated with higher negative urgency, a response tendency that predisposes to future hypo/mania. Here, we will use theta burst stimulation (TBS) over the left vlPFC in adults with BD and a comparison group of healthy adults/ non BD adults with either present or previous anxiety and/or non BD mood disorders to: 1) determine the impact of TBS on left vlPFC and related brain circuitry activity and functional connectivity during reward anticipation; 2) assess whether TBS-induced brain changes lead to acute changes in hypo/mania-related affect, and how negative urgency influences these TBS-induced changes in brain and affect measures; and 3) compare the impact of TBS on these brain and affect measures in adults with BD and healthy/ non BD adults.

PI_NAMEs: FERRARELLI, FABIO ;PHILLIPS, MARY LOUISE (contact)

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: Acute;Adult;Affect;Age;Amygdaloid structure;Anterior;Anxiety;Anxiety Disorders;Bipolar Disorder;Brain;brain circuitry;cingulate cortex;comparison group;Data;Decision Making;design;Development;Disease remission;Dorsal;Dose;Esthesia;Frustration;Functional Magnetic Resonance Imaging;Future;Gender;gray matter;hypomania;Impulsivity;Individual;Intervention;Lead;Left;Link;Manic;Measures;Mediating;Mental disorders;Mood Disorders;Nature;negative affect;neural;neural circuit;neural stimulation;Neuroanatomy;neuroimaging;neuromechanism;neuroregulation;Outcome;Participant;Pharmaceutical Preparations;Predisposition;Prefrontal Cortex;Randomized;Recording of previous events;recruit;repetitive transcranial magnetic stimulation;Reporting;response;Rest;reward anticipation;reward circuitry;reward expectancy;Rewards;Risk;Sampling;Scanning;Severities;Somatosensory Cortex;Stimulus;Techniques;transcranial direct current stimulation;Ventral Striatum;white matter;young adult

PROJECT_TITLE: Elucidating neural mechanisms of hypo/mania using theta burst stimulation


NIH_SPENDING_CATS: Cancer;Clinical Research;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE: B-cell chronic lymphocytic leukemia (CLL), the most common adult leukemia in the US, remains incurable and therefore there is an urgent need to develop new effective therapies based on a more precise understanding of disease pathophysiology. The objective of this proposal is to build upon our recent discovery of a previously unrecognized role for the Th17/IL-17 axis in improving the clinical course of CLL patients. Using a combination of molecular, cellular, and experimental model approaches, we will identify the pathways that induce and are mediated by the Th17/IL-17 axis in patients with CLL and that might be manipulated by the drug idelalisib to improve the outcome of patients with this still fatal disease.

PI_NAMEs: CHIORAZZI, NICHOLAS  (contact);SHERRY, BARBARA A

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Adoptive Immunotherapy;adult leukemia;Affect;Aftercare;antitumor effect;Autologous;B-Cell Activation;B-Cell Lymphomas;B-Lymphocytes;Biochemical;Biology;Blood;Cancer Cell Growth;CD4 Positive T Lymphocytes;Cell Count;Cell Differentiation process;cell growth;Cell Maturation;Cell model;Cell secretion;Cell Survival;Cells;Chronic Lymphocytic Leukemia;chronic lymphocytic leukemia cell;chronic T-cell leukemia;Clinical;cohort;Communication;Cues;curative treatments;cytokine;Data;Development;Disease;Disease Progression;effective therapy;Elements;Engraftment;Experimental Models;FDA approved;Functional disorder;Future;Generations;genetic approach;genome-wide analysis;Glean;Goals;Growth;Helper-Inducer T-Lymphocyte;IL17 gene;Immune;immune modulating agents;improved;improved outcome;In Vitro;in vivo;Individual;inhibitor;innovation;Knowledge;Laboratories;Learning;leukemia;Link;Lymphoid Tissue;Mediating;Membrane;MicroRNAs;Modality;Molecular;molecular modeling;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phosphorylation;Process;Proliferating;Publishing;receptor;Regimen;Regulation;Research;response;Role;Shapes;Signal Transduction;STAT3 gene;Stromal Cells;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Testing;Therapeutic;therapeutic effectiveness;trafficking;translational study;Treatment Efficacy;tumor microenvironment;Work;Xenograft procedure

PROJECT_TITLE: Th17 generation, action and therapeutic relevance in chronic lymphocytic leukemia

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Long term plans as well as moment to moment dynamic adjustments are a hallmark of flexible behavior  and the disruption of this ability is a common symptom in many psychiatric illnesses. The brain's  ability to coordinate between different temporal demands is a neuronal process that is currently  not well understood and the proposed studies, using a novel unconstrained and quasi-naturalistic  approach, will fundamentally advance that understanding.

PI_NAMEs: ZIMMERMANN, JAN  (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TITLE: Neural basis of behavioral timescale coordination

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: Project Narrative Schizophrenia is characterized by the presence of psychotic symptoms such as hallucinations. We still lack an understanding of how brain circuit dysfunction gives rise to hallucinations. In this project we seek to identify the brain circuit that causes these debilitating symptoms.

PI_NAMEs: BRADY, ROSCOE O.;HALKO, MARK A (contact)

PROJECT_TERMS: Address;Auditory Hallucination;Award;Behavior;Biological;Brain;BRAIN initiative;Brain region;Cerebellar Cortex;Cerebellar Diseases;Cerebellum;Clinic;Clinical;cohort;Data;debilitating symptom;Disabling;Disparate;experimental study;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Hallucinations;Human;Image;imaging biomarker;imaging study;individual variation;Intervention;Link;Location;Magnetic Resonance Imaging;Mental disorders;Modeling;National Institute of Mental Health;neural circuit;neuroimaging;neuroregulation;novel strategies;Observational Study;outcome disparities;Participant;Pattern;Phenotype;psychiatric symptom;Psychotic Disorders;psychotic symptoms;Publishing;Recording of previous events;recruit;reduce symptoms;restoration;Role;Schizophrenia;severe mental illness;Severities;sham-controlled study;standard care;Symptoms;Technology;Testing;Thalamic structure;Therapeutic;translational applications;Translations;Validation

PROJECT_TITLE: Empirical validation of a cerebellar-cortical hallucination circuit

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Diabetes;Infant Mortality;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Group B Streptococcus (GBS) is a leading cause of stillbirth and preterm birth, and women with gestational diabetes mellitus are uniquely susceptible to GBS complications for reasons unknown. This proposal aims to elucidate host and GBS factors that drive increased susceptibility to in utero GBS infection in gestational diabetic hosts, with the overall goal of uncovering novel therapeutic targets to treat GBS infection in pregnancy.

PI_NAMEs: MERCADO, VICKI  (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Address;Affect;Amniotic Fluid;Antibiotic Prophylaxis;Antibiotics;Bioinformatics;Candidate Disease Gene;career;Cell Line;Cells;Cervix Uteri;Cessation of life;Clinical;Coculture Techniques;Complex;cytokine;Data;design;diabetic;Diabetic mouse;Diet;Disease;Endometrial Stromal Cell;Environment;Enzyme-Linked Immunosorbent Assay;Epithelial Cells;Epithelium;Exhibits;Exposure to;Fatty acid glycerol esters;fetal;Fetal health;fetal infection;Fetus;Flow Cytometry;Functional disorder;Gene Expression;Genes;Genetic Transcription;Gestational Diabetes;Glucose;Goals;Group B Streptococcus colonization;Growth;Health;healthy pregnancy;Histology;Host Defense;Human;Hyperglycemia;Immune;Immune response;Immunity;Immunology;Impairment;improved;in utero;In Vitro;in vivo;in vivo Model;Incidence;Infant;Infant Mortality;Infection;innovation;insight;Insulin Resistance;Integration Host Factors;intrapartum;Invaded;Knowledge;knowledge base;Life;Liver;Macrophage;mast cell;Maternal Health;Maternal-Fetal Transmission;Measures;Mentorship;Metabolic;microbial;Microbiology;microbiome;microbiota;Modeling;mouse model;Mucous Membrane;Mus;mutant;Neonatal;neonatal morbidity;Neonatal Mortality;neonatal period;neonatal sepsis;neutrophil;new therapeutic target;non-diabetic;novel;novel therapeutic intervention;novel therapeutics;Nulliparity;Output;pathobiont;pathogen;Pathogenesis;Patient Care;Pediatrics;Physicians;Physiology;Placenta;Population;Predisposition;Pregnancy;pregnant;Premature Birth;Process;Production;prophylactic;Published Comment;Quantitative Reverse Transcriptase PCR;recruit;Regulation;reproductive;reproductive tract;Research Proposals;response;Risk;Role;Scientist;Shapes;Source;standard of care;stillbirth;Streptococcal Infections;Streptococcus Group B;Sucrose;Therapeutic;Tissues;tool;Training;transcriptome sequencing;transmission process;Uterus;Vagina;vaginal microbiota;Virulence;Virulence Factors;virulence gene;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Characterizing the Impact of Gestational Diabetes on Immunity and Group B Streptococcal Virulence in the Maternal Reproductive Tract


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Emerging Infectious Diseases;Infectious Diseases;Patient Safety;Prevention;Urologic Diseases

ORG_CITY: SYRACUSE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: SYRACUSE UNIVERSITY

PHR: Project Narrative Bacterial biofilms play important roles in nosocomial infections including catheter associated urinary tract infections. This project aims to engineer novel non-fouling catheters which can provide long-term (30 days or longer) prevention of microbial adhesion and on-demand removal of established biofilms on both sides of the catheter wall. The results will have direct impacts on patient care and recovery. Thus, it has significance in infection control, which is critical to public health.

PI_NAMEs: REN, DACHENG  (contact)

PROGRAM_OFFICER_NAME: FALCONE, JESSICA

PROJECT_TERMS: active control;Adhesions;Affect;anti-microbial drug;Antibiotics;antimicrobial;Antimicrobial Resistance;aqueous;Bacteria;Biomass;Bladder;Bladder Control;Blinded;Blood coagulation;catheter associated UTI;Catheterization;Catheters;Cells;Cellular Structures;Cessation of life;Copper;cytokine;design;Development;Dose;Drainage procedure;Electromagnetic Fields;Engineering;Environment;Enzyme-Linked Immunosorbent Assay;Excision;experimental study;Extracellular Matrix;fabrication;Failure;fluorescence imaging;Frequencies;Gender;Gene Expression Profiling;Goals;Growth;healthcare-associated infections;High Prevalence;Histologic;Hour;Immunity;In Vitro;in vivo;in vivo evaluation;Infection;Infection Control;Infection prevention;Infective cystitis;Inflammation;Kidney;Left;lithography;Long-Term Care;Magnetism;mechanical properties;Medical;meter;Methods;Microbe;microbial;Microbial Biofilms;Modeling;Molds;Morbidity - disease rate;mortality;Motility;Movement;Mucous body substance;Mucous Membrane;multidrug tolerance;Multiple Bacterial Drug Resistance;nanoparticle;Nosocomial Infections;novel;Operative Surgical Procedures;Oryctolagus cuniculus;Patient Care;Patients;Pattern;Phagocytosis;Physiology;Play;Polymers;Predisposition;Prevalence;prevent;Prevention;Production;Proteus mirabilis;prototype;Public Health;rational design;Recovery;Research;Role;Route;Safety;Side;simulation;Surface;Technology;technology platform;Testing;United States;Urease;Urethra;urinary;Urinary tract;Urine;Uropathogenic E. coli;Virulence Factors

PROJECT_TITLE: Controlling Catheter-Associated Urinary Tract Infections Using Smart Catheters with Rationally Designed Active Topographies

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: FORT COLLINS

ORG_DEPT: CHEMISTRY

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: Project Narrative. This project aims to develop new chemical tools that enable biologically active molecules to be constructed. In particular, coupling reactions that form carbon-carbon and carbon-heteroatom bonds in molecules designed as therapeutic agents are targeted. Zincke imine intermediates are used as the enabling technology that could result in new drug candidates and methods for low-cost manufacture.

PI_NAMEs: MCNALLY, ANDREW  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Acids;Acylation;adduct;ADME Study;Aldehydes;Alkenes;Ammonium;aqueous;Biological;Carbon;Cell Respiration;Chemicals;Chemistry;clinical candidate;Complex;Coupling;Cyclization;design;drug candidate;Drug Design;drug development;drug discovery;Drug Receptors;drug standard;Electronics;Electrons;FDA approved;functional group;Goals;halogenation;Hydrazines;Hydrogen Bonding;Hydroxylamine;Imines;Intercept;Ions;Isotopes;manufacturing cost;Mediating;Medicine;Metabolic;Metals;Methods;Modernization;Nitrogen;novel therapeutics;operation;Oxides;Pattern;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacologic Substance;physical property;piperidine;Positioning Attribute;Process;programs;Property;pyridine;Reaction;receptor binding;Research;Resistance;Salts;scaffold;Series;small molecule;Solubility;Structure;Structure-Activity Relationship;System;targeted treatment;Technology;tool;Toxicology;Variant

PROJECT_TITLE: A New General Strategy for Pyridine Functionalization via Dearomatized Intermediates

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: PROJECT NARRATIVE The proposed research follows a sample of 340 underrepresented college students (ages 18-21) into early adulthood (ages 25-30) to examine 1) the prospective and cumulative consequences of marginalizing experiences during college and early adulthood on individuals’ physical health and aging processes and 2) the role of social supports and resources in countering or mitigating harm resulting from marginalizing experiences. The project has strong relevance to public health in that it aims to illuminate physiologic processes resulting from social inequities that help to explain disparities in diseases such as diabetes and cardiovascular disease. A more comprehensive understanding of risk and resilience processes and variability in how they play out among upwardly mobile marginalized groups will shed light on opportunities for interventions (e.g., trainings to reduce discrimination in predominantly white educational and employment settings, targeted programs to provide support to individuals facing marginalization) that hold the potential to facilitate social mobility while also preserving and bolstering the health of minority groups.

PI_NAMEs: ALLEN, JOSEPH PATRICK;HURD, NOELLE M (contact)

PROJECT_TERMS: Acceleration;Adult;Affect;Age;Aging;aging process;Attention;Biological Markers;cardiometabolism;Cardiovascular Diseases;Career Mobility;Caregivers;Chronic Disease;college;Degree Completion;Development;Diabetes Mellitus;Discipline;Discrimination;Disease;Disparity;economic outcome;Education;Eligibility Determination;emerging adult;emerging adulthood;Employment;epigenetic aging;ethnic minority status;Ethnic Origin;Ethnic Population;Etiology;experience;First Generation College Students;Fostering;Future;Grant;Health;health disparity;higher education;Individual;Inequality;Inequity;Inflammatory;Institution;Intervention;Learning;Life Cycle Stages;Light;Longitudinal Studies;Maintenance;marginalization;marginalized population;Measurement;member;Mental disorders;Minority Groups;minority health;National Institute on Minority Health and Health Disparities;Onset of illness;Outcome;Participant;Pathway interactions;peer;perceived discrimination;physical conditioning;Physiological;Physiological Processes;Play;preservation;Process;prognostic indicator;programs;prospective;protective effect;Public Health;Race;racial minority;racial population;rate of aging;recruit;Reduce health disparities;Research;resilience;Resources;retention rate;Risk;Risk Behaviors;Risk Factors;Role;Sampling;Skin;social;Social Identification;Social Mobility;social space;Social status;Social support;Societies;Socioeconomic Status;socioeconomics;Source;stressor;Students;substance use;Testing;Time;Training;Underrepresented Students;university student;Vision;Vulnerable Populations;Well in self;young adult

PROJECT_TITLE: Examining the physical toll of marginalizing experiences in emerging adulthood and exploring resilience possibilities

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Patient Safety;Primary Health Care;Social Determinants of Health

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Healthcare providers are increasingly using electronic health records to document social / economic risk factors like food, transportation, and housing insecurity, since these factors can profoundly impact patients’ health and ability to follow care recommendations. However, little is known about how healthcare teams can best use this newly available social risk information to adapt care plans to meet patients’ needs. We will use patient and provider input to develop ‘social risk-informed’ care adaptation recommendations, then build these recommendations into clinical decision support tools in 12 CHCs’ electronic health record. We will examine how providers and patients use these tools, what they think of them, and how they affect patient health outcomes.

PI_NAMEs: GOLD, RACHEL  (contact);GOTTLIEB, LAURA

PROJECT_TERMS: Academy;Accounting;Address;Affect;American College of Physicians;arm;Assessment tool;blood pressure control;Caring;Clinical;clinical decision support;Clinical Decision Support Systems;clinical risk;community-level factor;contextual factors;Data;Depression screen;design;Disparity population;disparity reduction;Documentation;Economics;Electronic Health Record;electronic health record system;Engineering;Evaluation;experience;Feedback;follow-up;Food;food resource;Glycosylated hemoglobin A;Health;health care availability;health disparity;health equity;health inequalities;health outcome disparity;Health Personnel;Healthcare;Healthcare Systems;Homelessness;Hospitalization;Housing;housing instability;Hypoglycemia;improved;improved outcome;Inequity;Information Services;innovation;Insulin;Intervention;Interview;Intuition;Laboratories;Link;Measures;Medical;Medical Care Team;Medicine;Modeling;Neighborhood Health Center;Neighborhoods;Outcome;patient engagement;patient-clinician communication;Patient-Focused Outcomes;Patients;Perception;Pharmaceutical Preparations;pilot test;primary outcome;Process;Provider;Public Health;Quality of Care;Race;Randomized;Recommendation;Recording of previous events;Refrigeration;Reporting;Research;response;Risk;Risk Factors;Running;safety net;screening;secondary analysis;secondary outcome;Services;Shapes;social;Social Conditions;social determinants;social engagement;social health determinants;Social isolation;Social Work;Suggestion;support tools;Surveys;Testing;tool;Transportation;trend;United States National Academy of Sciences;usability;Visit;Work

PROJECT_TITLE: COHERE – COntextualized care in cHcs’ Electronic health Records

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-A(56)R]


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Genetics;Hepatitis;Hepatitis - C;Immunization;Infectious Diseases;Liver Disease;Prevention;Vaccine Related

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: Attenuated live-virus vaccines confer highly effective and long-lived immunity against several viruses. This project will use a rodent HCV-like virus model to develop a sequence-independent approach to make a live attenuated vaccine for a virus that otherwise is highly efficient in establishing life-long chronic infection in an immunocompetent host.

PI_NAMEs: KAPOOR, AMIT  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Acute;Acute Disease;adaptive immunity;Adenine;Animal Model;Attenuated;Attenuated Live Virus Vaccine;Attenuated Vaccines;attenuation;Bioinformatics;Biological Assay;biological systems;Cell Culture System;Cells;Chronic;Chronic Disease;Chronic Hepatitis C;chronic infection;Codon Nucleotides;Communication;CpG dinucleotide;Cytosine;design;Development;Dinucleoside Phosphates;Frequencies;Future;Genes;Genome;Genomic Segment;Guanine;Hepatitis C;Hepatitis C Vaccine;Hepatitis C virus;Hepatitis C-Like Viruses;Hepatology;Human;Immune;Immune response;Immunity;Immunocompetent;In Vitro;in vivo;Individual;Infection;interest;Interferons;Investments;Journals;Modeling;Modernization;Mutagenesis;mutant;Mutate;Mutation;Natural Immunity;Nature;Nucleotides;Outcome;pathogen;Pathogenesis;pathogenic virus;Pathogenicity;Pathway interactions;Play;preservation;prevent;Rattus;recombinant virus;Research;RNA;RNA Viruses;Rodent;Role;Science;Serial Passage;Serum;Solid;Species Specificity;Structure;T-Lymphocyte;transcriptome;transcriptome sequencing;Uracil;vaccination strategy;Vaccines;Variant;Vertebral column;Viral;Viral Genome;Viremia;virology;Virus;Virus Diseases

PROJECT_TITLE: A sequence-independent approach for attenuating hepaciviruses

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: Narrative: Immune cytokines provide host protection but are also implicated in host sickness responses Here, we investigate a regulatory pathway involving immune cytokine control of the systemic levels of the stress hormone GDF-15, a major mediator of appetite suppression and weight loss. Insights from this study might provide treatment modalities to dampen the sickness response that ensues during a cytokine storm without diminishing host protective effects.

PI_NAMEs: YAP, GEORGE S. (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Affect;Animals;Biochemical;Biological Availability;Biological Response Modifiers;Body Weight decreased;cell type;Cells;Clinical;Communicable Diseases;cytokine;cytokine release syndrome;Data;Desire for food;Disease;Disease Management;Eating;Exhibits;GDF15 gene;Genetic;Health Promotion;Hematopoietic;hindbrain;Hormones;human disease;Immune;Immune response;Immunologics;immunoregulation;Infection;Inflammatory;insight;Interferon Type II;Interleukin-10;Lymphocyte;Macrophage;Malignant Neoplasms;Mediating;Mediator;Modality;Mus;novel;Outcome;pathogen;Pathogenicity;protective effect;receptor;Regulation;Regulatory Pathway;Reporting;resistance mechanism;response;Role;Stress;stressor;Testing;Tissues;Toxoplasma;Toxoplasma gondii;Toxoplasmosis

PROJECT_TITLE: GDF-15 as a mediator of immune-regulated sickness response during infection

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative This exploratory research will generate fundamental information necessary to better understand the functional basis of the tsetse fly-Sodalis symbiosis as it relates to trypanosome infection in the fly. We will determine whether a putative Sodalis endochitinase exhibits chitinolytic activity, and if this enzyme degrades the chitinous component of tsetse’s peritrophic matrix such that the structure becomes a less effective barrier against trypanosome infection establishment. Collectively, findings from this research will provide functional insight into the physiological mechanisms that mediate trypanosome infection establishment and transmission through the tsetse fly vector.

PI_NAMEs: WEISS, BRIAN L (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TITLE: Endosymbiont mediated chitin catabolism in the tsetse fly gut impacts trypanosome transmission

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Natural Products;Prevention

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS ENGINEERING EXPERIMENT STATION

PHR: NARRATIVE Indiscriminate use of antibiotics conjoined with natural evolution has created a situation where conventional antibiotics are no longer effective, raising the risk of being plunged back into an era similar to the pre-antibiotic period. To address this global crisis, we have developed an innovation that enables the simultaneous screening of compounds with antimicrobial and/or host-dependent anti-infective activities, thereby dramatically enhancing the target space for thwarting antimicrobial resistant (AMR) bacteria. The goal of this project is to develop and exploit a high-throughput microfluidic screening system named GUARD to identify new classes of molecules that either directly kill multi-drug resistant (MOR) bacteria or provide host-dependent anti-infective activities that can thwart AMR bacteria, as well as determine their mechanisms of action.

PI_NAMEs: JAYARAMAN, ARUL  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acinetobacter baumannii;Address;Anti-Bacterial Agents;Anti-Infective Agents;Antibiotics;antimicrobial;Antimicrobial Resistance;Back;bacterial resistance;Biological Assay;Categories;Cells;Chemicals;Clinical;combat;Complex;Computational Biology;Consumption;cost;Data;Development;digital;drug discovery;emerging antimicrobial resistance;Engineering;Ensure;Environmental Microbiology;Equilibrium;Evolution;Goals;Growth;Habitats;Harvest;Health;Human;Immune;Immune response;Infection;Infection prevention;Inflammation;innovation;Integration Host Factors;Laboratories;Lead;metabolomics;Methicillin Resistance;methicillin resistant Staphylococcus aureus;Microbe;microfluidic technology;Microfluidics;Multi-Drug Resistance;Multidrug-resistant Acinetobacter;Multiple Bacterial Drug Resistance;Names;Natural product discovery;Natural Products;Natural Products Chemistry;novel;Outcome;pathogen;Pathology;Phenotype;Preclinical Testing;prevent;prototype;Pseudomonas aeruginosa;Qualifying;Recovery;Research;research clinical testing;Research Personnel;Resolution;Risk;Safety;scaffold;Scientist;screening;Site;small molecule;System;Systems Development;Testing;Therapeutic;Time;Toxic effect;Work;World Health Organization

PROJECT_TITLE: GUARD: A global unbiased antimicrobial discovery platform

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Clinical Research;Complementary and Integrative Health;Microbiome;Nutrition

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Humans constantly encounter new microbes in their diets and environments, but only a tiny fraction of these microbes become long-term residents of the adult gut microbiome. Understanding the ecological forces that shape microbial colonization and transmission is essential for developing targeted microbiome therapeutics. We will study colonization and transmission dynamics in a longitudinal household cohort after antibiotic exposure, and we will perform experiments in stool-derived microbial communities to test the ecological factors that affect microbial colonization.

PI_NAMEs: RELMAN, DAVID A. (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TITLE: Household transmission of the human gut microbiota after antibiotic exposure

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Clinical Research;Genetics;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SAN ANTONIO

ORG_NAME: TEXAS BIOMEDICAL RESEARCH INSTITUTE

PHR: NARRATIVE Drug resistance mutations tend to interrupt key physiological processes and carry a fitness costs, which can be mitigated by evolution of compensatory mutations. These compensatory mutations are poorly understood and characterized in Plasmodium falciparum and are the focus of this proposal. We will use both laboratory and field based approaches to identify compensatory mutations and then use CRISPR editing to define the impact of candidate mutations in restoring fitness to drug resistant parasites.

PI_NAMEs: ANDERSON, TIM J (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Africa;Alleles;Amino Acid Transporter;Anti-malarial drug resistance;Anti-malarials;Aromatic Amino Acids;Artemisinins;Asia;Asian;Biochemical Pathway;Biological Assay;Candidate Disease Gene;Chloroquine;Chloroquine resistance;Chromosome Mapping;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Collection;Combined Modality Therapy;Compensation;cost;CRISPR/Cas technology;Data;Dental caries;Drug Combinations;drug mechanism;Drug resistance;Drug usage;drug-sensitive;Endocytosis;Evolution;experimental analysis;Experimental Genetics;experimental study;fitness;Food;Frequencies;Gene Frequency;Genes;genetic approach;Genetic Crosses;Genetic Transcription;genome sequencing;genome wide association study;Genomics;Genotype;Haplotypes;Hydrolase;Impairment;improved;In Vitro;Interruption;Laboratories;Link;Malaria;Maps;Membrane;Metabolic;Metabolic Pathway;Methods;Modification;Monitor;Mutation;Myanmar;Parasite resistance;Parasites;pathogenic bacteria;Pathway interactions;Pattern;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Physiological Processes;Plasmodium falciparum;Play;Population;pressure;programs;Proteins;Quinolones;Research;Resistance;resistance gene;resistance mutation;response;reverse genetics;risk minimization;Role;Testing;transcriptomics;Ubiquitin;Vacuole;Variant;Withdrawal;Work

PROJECT_TITLE: Mapping Drug Resistance Genes in Plasmodium falciparum

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-B(83)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Cervical Cancer;Genetics;Human Genome;Infectious Diseases;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: INDIANAPOLIS

ORG_DEPT: DERMATOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative This grant proposes to develop a mouse model that can be infected with a human papillomavirus and cause disease. This would be very useful to test and validate novel antiviral therapies before proceeding to the first human clinical trials with a potential new drug.

PI_NAMEs: ANDROPHY, ELLIOT J. (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Address;Animal Model;Animals;Anti-viral Agents;Anti-viral Therapy;antibiotic G 418;Anus;Binding;Biological Models;Bypass;Carcinoma in Situ;Cell Culture Techniques;Cell Line;Cells;Cervical;Clinical Trials;Country;design;Development;Disease;DNA biosynthesis;DNA cassette;drug development;drug testing;drug-like compound;Dysplasia;Early treatment;Episome;Epithelial Cells;Epithelium;Etiology;Excision;experimental study;first-in-human;Genes;Genetic Transcription;Genitalia;Genome;Goals;Grant;High Prevalence;HPV E7;Human;Human papilloma virus infection;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16;Immunodeficient Mouse;in vivo;in vivo evaluation;Infection;Infectious Skin Diseases;Interruption;Investigation;keratinocyte;Lesion;Link;Maintenance;Malignant Neoplasms;Mediating;Messenger RNA;Modeling;Molecular;Monitor;mouse model;Mus;Mutation;Neomycin;novel;novel therapeutics;Oncoproteins;Operative Surgical Procedures;Oral;Oral cavity;Oral mucous membrane structure;Oropharyngeal;Papilloma;Papillomavirus;Papillomavirus Transforming Protein E6;Pathogenesis;Persons;Pharmaceutical Preparations;Preclinical Drug Development;premalignant;Prognosis;programs;Proliferating;protein expression;Proteins;research clinical testing;Resistance;Resources;Risk Reduction;RNA Splicing;Rodent Model;scale up;Series;Skin;Species Specificity;stability testing;Stress;System;Techniques;Testing;Therapeutic;therapeutic evaluation;Tissues;tool;Topical application;tumor;tumor progression;Validation;Viral;Viral Genome;Viral Proteins;Virus Replication;women's diagnosis

PROJECT_TITLE: Development of a mouse model to test HPV Antiviral compounds

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-S(02)]