NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Breast Cancer;Cancer;Clinical Research;Mental Health;Neurosciences;Rehabilitation;Women's Health Research

ORG_CITY: RICHMOND

ORG_DEPT: PSYCHIATRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE During the last decade there has been progress in defining the neurocognitive changes associated with breast cancer from pretreatment to post treatment, but little is known about how the neurocognitive changes beyond 1-3 years post treatment. It is possible that cancer related cognitive impairments result from accelerated aging processes, and if so, we need a better understanding of survivors’ neurocognitive changes beyond 3 years. To begin addressing these limitations, we aim to extend our current prospective study (CA172145), which longitudinally examines cognitive function and brain structure/function pre-surgery to 1-year post chemotherapy. In the proposed competing renewal study, we will continue to assess our breast cancer cohort at yearly intervals for 5 additional years providing unique longitudinal data up to 10 years post-chemotherapy. The proposed project will extend our knowledge on very long-term neurocognitive outcomes following breast cancer chemotherapy

PI_NAMEs: KESLER, SHELLI R;PALESH, OXANA G (contact)

PROGRAM_OFFICER_NAME: GREEN, PAIGE A

PROJECT_TERMS: Acceleration;Address;Aftercare;Age;age acceleration;Aging;aging brain;aging process;Brain;Breast Cancer survivor;cancer-related cognitive impairment;chemobrain;chemotherapy;Chemotherapy-Oncologic Procedure;clinically significant;Cognition;Cognitive;cognitive change;Cognitive deficits;cognitive function;cognitive neuroscience;cognitive testing;cohort;comparison control;connectome;Control Groups;Data;Decision Making;Disease remission;Elderly;experience;follow-up;Funding Mechanisms;high risk;Impaired cognition;Impairment;Incidence;Knowledge;Literature;Long term disability;Longitudinal Studies;longitudinal, prospective study;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Methods;Morbidity - disease rate;mortality;Nature;neural;neural circuit;Neurobiology;Neurocognitive;neuroimaging;neuromechanism;Neuropsychological Tests;Neuropsychology;Outcome;Participant;Patients;Performance;Phenotype;Physiological Processes;Prospective Studies;Quality of life;Reporting;Research;resilience;standardize measure;Structure;Survivors;Time;Women's cohort;women's treatment;Work

PROJECT_TITLE: Very-long Term Neurocognitive Outcomes in Breast Cancer Survivors (ProbC2)


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences

ORG_CITY: IOWA CITY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Memory deficits are found with many neurological disorders such as Alzheimer's disease and following stroke; the breakdown of interactions between memory systems can be particularly debilitating. This proposal examines the neural mechanisms underlying interactions between emotional and motor memory systems during associative learning. Elucidating the neural mechanisms underlying memory system interactions is potentially important for developing treatments for memory deficits.

PI_NAMEs: FREEMAN, JOHN H (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TITLE: Cerebellar Interactions with the Amygdala and Prefrontal Cortex during Learning

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Digestive Diseases;Immunotherapy;Nanotechnology;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Narrative We develop a nanoparticle strategy to modulate T cell functionality and methods incorporating imaging and sequencing to assess response. We will apply these strategies here to cure pancreatic cancer.

PI_NAMEs: FERRARA, KATHERINE W (contact);LEVY, RONALD

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: Abbreviations;Abraxane;Acids;adaptive immune response;Address;Adverse event;Agonist;Animal Model;Animals;anti-CTLA4;anti-PD-1;Biological Assay;biomaterial compatibility;Biopsy;Cancer Etiology;Cells;Characteristics;checkpoint therapy;Chemistry;chemotherapy;Clinical Treatment;Clinical Trials;Combined Modality Therapy;Complex;Data;Dendritic Cells;Detection;Development;Diagnosis;Dose;Drug Kinetics;efficacy evaluation;Environment;Esterification;Extravasation;Flow Cytometry;Formulation;gastrointestinal;gemcitabine;Goals;Head and Neck Cancer;Image;Immune;Immune response;ImmunoPET;Immunophenotyping;immunoregulation;Immunotherapy;Implant;improved;In Vitro;in vivo;Interferons;Kidney;Lectin;Leukocytes;lipophilicity;Lymphoma;Macrophage;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;Mannose;Metals;Methods;Modeling;Modernization;Monitor;Monoclonal Antibodies;mortality;mouse model;Mus;Myeloid-derived suppressor cells;nanoformulation;nanoparticle;nanoparticle delivery;nanotherapeutic;nanotherapy;Nature;non-invasive monitor;OX40;PADRE 45;pancreatic cancer cells;pancreatic cancer model;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic neoplasm;particle;Pathway interactions;Patients;Peptides;Phenotype;Polymers;Positron-Emission Tomography;preclinical study;predicting response;Prognosis;Property;Protocols documentation;Reaction;receptor;Reporting;resiquimod;Resistance;response;Rodent;Safety;Sampling;scaffold;Site;small molecule;specific biomarkers;T cell response;T-Cell Activation;T-Lymphocyte;Techniques;Testing;Therapeutic;Therapeutic Index;Time;TLR7 gene;TNFRSF5 gene;Toll-like receptors;Toxic effect;transcriptome sequencing;translation to humans;Translations;treatment optimization;tumor;tumor microenvironment;Unresectable;Update;uptake;Work

PROJECT_TITLE: Imaging Modulation of Immune Phenotype


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Lung;Neurosciences

ORG_CITY: PORTLAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: This project will identify the mechanism of eosinophil-induced airway hyperinnervation in asthma and measure consequences of nerve remodeling on airway physiology. We will also test whether airway nerve remodeling is attenuated in humans with asthma by studying nerves in bronchoscopic airway biopsies before and after initiation of anti-IL5 antibody mepolizumab treatment.

PI_NAMEs: DRAKE, MATTHEW G. (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: 3-Dimensional;Abbreviations;afferent nerve;airway epithelium;airway inflammation;Antibodies;Asthma;asthmatic;Attenuated;Biopsy;Brain-Derived Neurotrophic Factor;Bronchoconstriction;Cells;computerized;Confocal Microscopy;Cytoplasmic Granules;Data;density;Development;Drug Targeting;eosinophil;Eosinophil Granule Proteins;eosinophil peroxidase;Eosinophilia;Functional disorder;Goals;Growth;Histologic;Human;IL5 gene;Image;improved;Individual;Inhalation;innovation;Interleukin-5;Irritants;Knockout Mice;Length;Link;Lung;Measures;Mediating;mepolizumab;meter;Methodology;Methods;Morphology;mouse model;Mus;Muscarinic Antagonists;Nerve;Nerve Growth Factor Receptors;Nerve Growth Factors;nerve supply;Neurons;Neuropeptides;Neurotransmitters;neurotrophic factor;Neurotrophic Tyrosine Kinase Receptor Type 1;Optics;overexpression;Pathway interactions;Phosphotransferases;Physiology;prevent;Proteins;pulmonary function;Pyroglyphidae;receptor;reconstruction;Reflex action;respiratory smooth muscle;response;Role;Sensory;Slice;Specimen;Stains;Structure;Structure of parasympathetic ganglion;Testing;Thick;tiotropium;Tissues;Transgenic Organisms;Tropomyosin

PROJECT_TITLE: Identifying mechanisms and reversibility of eosinophil-induced airway hyperinnervation in asthma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-H(03)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease;Networking and Information Technology R&D (NITRD);Orphan Drug;Rare Diseases

ORG_CITY: MAYWOOD

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

ORG_STATE: IL

PHR: Hepatitis delta virus (HDV) is the most severe form of chronic viral hepatitis. While there are currently no approved therapies for HDV, both interferon- and interferon-λ, and other clinically relevant therapeutics such as nucleic acid polymers, myrcludex B, and a new prenylation inhibitor, lonafarnib, are being investigated as anti-HDV treatments. Using kinetic data from clinical trials and novel humanized mouse models of HDV and hepatitis B virus (HBV) infections, we propose to develop new mathematical models to elucidate the dynamics of HDV-HBV-host infection and treatment response in order to determine how to effectively treat HDV.

PI_NAMEs: DAHARI, HAREL  (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: Acceleration;adaptive immune response;American;analog;Anti-viral Agents;Anti-viral Therapy;Blood;Cells;Chronic;Chronic Hepatitis B;Chronic Hepatitis D;chronic infection;Chronic viral hepatitis;circular RNA;Clinical;Clinical Data;clinical efficacy;Clinical Treatment;Clinical Trials;clinically relevant;co-infection;Collaborations;Computer Models;Data;Development;env Gene Products;Evaluation;Experimental Models;experimental study;extracellular;FDA approved;Genome;Genotype;Goals;Half-Life;Hepatitis B Infection;Hepatitis B Surface Antigens;Hepatitis B Virus;Hepatitis D;Hepatitis Delta Virus;Hepatocyte;Human;humanized mouse;Individual;infancy;Infection;Infectious hepatitides;inhibitor;insight;Interdisciplinary Study;Interferon Type II;Interferons;intrahepatic;Kinetics;Knowledge;Life Cycle Stages;Link;Liver diseases;Lonafarnib;mathematical model;Mathematics;Modeling;Molecular;Monitor;mouse model;Mus;novel;Nucleic Acids;Patients;Pegylated Interferon Alfa;permissiveness;Persons;Pharmaceutical Preparations;Polymers;prenylation;Prevalence;Recommendation;Relapse;response;screening;System;Testing;Therapeutic;Time;treatment optimization;treatment response;Viral;Virion;Virus;Virus Assembly;Virus Diseases;Virus Replication

PROJECT_TITLE: Data-Driven Mathematical and  Computational Modeling of Hepatitis D Infection and Treatment Response

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Immunization;Immunotherapy;Prevention;Vaccine Related;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: SURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative The proposed research is relevant to public health because it seeks to mechanistically understand how best to  combine targeted antibody and vaccine treatments with immune checkpoint blockade immunotherapies. This  knowledge will ultimately improve the efficacy of existing targeted antibody therapies and immunotherapies, extend the range of these combinations to different tumor types, and reduce the toxicity of these combinations. Thus, the proposed research is relevant to the part of the NIH’s mission that pertains to developing innovative research strategies and their application to protect and improve human health.

PI_NAMEs: HARTMAN, ZACHARY CONRAD (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: anti-CTLA4;anti-PD-1;anti-tumor immune response;Antibodies;antibody immunotherapy;Antibody Response;Antibody Therapy;antibody-dependent cellular phagocytosis;antigen-specific T cells;Antigens;antitumor effect;Antitumor Response;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;cancer type;CCR;CD47 gene;CD47-SIRPα;Cells;Chemotherapy and/or radiation;Clinical;Clinical Pathways;Clinical Research;Clone Cells;Complement;Complement 3a;Complement 5a;Complement Activation;Critical Pathways;CTLA4 gene;Data;Deposition;effector T cell;Epitopes;ERBB2 gene;Health;Human;Immune;immune cell checkpoints;immune checkpoint blockade;Immune Tolerance;Immunity;Immunocompetent;Immunologics;Immunosuppression;Immunotherapy;improved;in vivo;Infiltration;Inflammation;innate immune checkpoint;innovation;insight;Knockout Mice;Knowledge;Lymphoma;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Mediator;Mission;Modeling;Monoclonal Antibodies;MS4A1 gene;Mus;neoantigens;Non-Hodgkin's Lymphoma;Oncology;Outcome;Pathway interactions;patient response;patient subsets;PD-1 blockade;PD-1/PD-L1;Phagocytes;Phagocytosis;Phase I Clinical Trials;Phase II Clinical Trials;polyclonal antibody;prevent;programmed cell death protein 1;Public Health;Publishing;Radiation therapy;recruit;Regulatory T-Lymphocyte;Reporting;Research;Resistance;resistance gene;response;Signal Transduction;Solid;Solid Neoplasm;standard of care;synergism;T cell response;T-Lymphocyte;Testing;Therapeutic;Toxic effect;trafficking;Trastuzumab;triple-negative invasive breast carcinoma;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;United States National Institutes of Health;Vaccination;vaccine strategy;Vaccines

PROJECT_TITLE: Enabling effective anti-tumor immunity from targeted antibodies through dual innate and adaptive immune checkpoint blockade in non-immunogenic cancers

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: SEATTLE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: The human fovea is essential for best vision but understanding the crucial cellular interactions among photoreceptors, neural circuits and supporting non-neural cells in the foveal center is limited because the extremely miniaturized and complex three-dimensional structure and synaptic organization of this region is difficult to untangle with conventional methods. The proposed project will apply new methods of volume electron microscopy (“connectomics”) to reconstruct the human fovea for the first time. Outcomes will have broad significance for retinal neuroscience, clinical image interpretation, and the pathophysiology of macular disease, especially age-related macular degeneration.

PI_NAMEs: DACEY, DENNIS MICHAEL (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: 3-Dimensional;Accounting;Address;Adult;Age related macular degeneration;Aging;Anatomy;Apical;Appearance;Architecture;Area;Axon;Biological Process;Catalogs;cell type;Cells;Cellular Morphology;Characteristics;Clinical;Clinical assessments;clinical imaging;Complex;Cone;connectome;Data;density;Development;direct application;Disease;disorder of macula of retina;Electron Microscopy;Epithelial Cells;Eye;Female;Floor;fovea centralis;Functional disorder;Future;ganglion cell;Goals;Health Status;Human;Image;Image Analysis;in vivo imaging;Individual;innovation;insight;Lead;Link;Lipofuscin;Location;Machine Learning;macula;male;Mediating;Melanosomes;Methods;Miniaturization;miniaturize;Mitochondria;Morphology;Muller's cell;neural;neural circuit;Neurobiology;Neurosciences;nonhuman primate;novel;Optical Coherence Tomography;Organ Donor;Organelles;Outcome;Pathology;pathology imaging;Pathway interactions;Persons;Photoreceptors;Pigments;postsynaptic;Process;programs;reconstruction;Recovery;Research;resilience;Resources;Retina;Retinal Cone;Retinal Diseases;Rod;Services;Signal Transduction;Source;Structure;Structure of retinal pigment epithelium;Supporting Cell;Synapses;Technology;Testing;three dimensional structure;Time;Tissues;tool;Variant;Vertebrate Photoreceptors;Vision;Visual Acuity;Visual Pathways;visual performance;Work

PROJECT_TITLE: The Human Foveal Connectome


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;HIV/AIDS;Hepatitis;Infectious Diseases;Liver Disease;Nutrition;Prevention

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Nonalcoholic steatohepatitis are important causes of morbidity and mortality in individuals who are infected with HIV and yet no rigorous studies have been conducted to date to optimally characterize this condition and to develop novel therapies. We propose four well designed specific aims to address high priority knowledge gaps plaguing this condition.

PI_NAMEs: CHALASANI, NAGA P (contact);LOOMBA, ROHIT ;SULKOWSKI, MARK SEBASTIAN

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Address;Adult;Adverse event;Adverse reactions;Age;Agonist;Alcohols;Ancillary Study;antiretroviral therapy;Area;Beverages;biobank;Biochemistry;Biopsy;Body Weight;cardiovascular risk factor;CD4 Positive T Lymphocytes;Cell Count;Characteristics;chronic liver disease;Clinical;clinical center;Clinical Data;clinical predictors;Clinical Research;Clinical Trials;Coffee;cohort;Cross-Sectional Studies;Data;Data Coordinating Center;Databases;design;Diagnostic;Diet;Disease;Double-Blind Method;elastography;Eligibility Determination;Ethnic Origin;European;Exclusion;Fatty Liver;fatty liver disease;Feces;Fibrosis;food insecurity;Frequencies;Funding;Gender;General Population;genetic risk factor;genetic variant;Genomic DNA;gut microbiome;High Prevalence;Histologic;Histology;HIV;HIV Infections;improved;Individual;Infection;Inflammation;Insulin Resistance;interest;Knowledge;Lipoproteins;Liver;liver biopsy;Liver diseases;Liver Fibrosis;Lobular;meetings;Metabolic;Mission;Morbidity - disease rate;mortality;multi-ethnic;Multicenter Studies;National Institute of Diabetes and Digestive and Kidney Diseases;non-alcoholic fatty liver;non-genetic;nonalcoholic steatohepatitis;novel;novel therapeutics;Obesity;Observational Study;Oral;Participant;Pathogenesis;Pathology;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Physical activity;Placebo Control;Placebos;Plasma;Population;PPAR alpha;pre-clinical;Prevalence;primary endpoint;prognostic;prospective;Protocols documentation;Quality of life;Race;Randomized;Randomized, Controlled Trials;recurrent infection;Research;Research Infrastructure;research study;Resolution;response;Risk;Risk Factors;RNA;Safety;Schedule;secondary endpoint;Seminal;Serious Adverse Event;Serum;Serum Markers;sex;Site;Sleep;System;Testing;Therapeutic;Transaminases;United States;Urine;vibration;Work;working group

PROJECT_TITLE: Ancillary Studies of NAFLD and NASH in HIV infected Adults


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Immunotherapy

ORG_CITY: CLEVELAND

ORG_DEPT: GENETICS

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Colorectal cancer is the second most common cause of cancer deaths in the United States, with 133,000 new cases and 50,000 deaths per year. Thus, novel therapies are urgently needed to treat this deadly disease. The goal of this project is to develop a new personalized approach to treat colorectal cancers. We discovered that colorectal cancers with an abnormality (called a mutation) in a gene called Erbb3 require are sensitive to immunotherpy in mouse models. Here we propose further investigate this exciting finding with a goal to bring it to potential clinical trials to test the concept in colorectal cancer patients in the future.

PI_NAMEs: WANG, ZHENGHE  (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: anti-PD1 antibodies;anti-PD1 therapy;Antibody Therapy;biomarker identification;cancer cell;Cancer Etiology;Cancer Model;cancer therapy;Carcinogens;Cell Line;Cells;Cessation of life;Clinical Trials;colon cancer cell line;colon cancer patients;Colon Carcinoma;colon tumorigenesis;Colonic Neoplasms;Colorectal;Colorectal Cancer;Data;Disease;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Family;Family member;Foundations;Future;Gene Expression;Genes;Genetically Engineered Mouse;Goals;Growth;Human;humanized mouse;Immune checkpoint inhibitor;immunomodulatory therapies;Impairment;innovation;Interferon Type II;IRS1 gene;kinase inhibitor;Knock-in;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;member;metastatic colorectal;Microsatellite Instability;Microsatellite Repeats;mimetics;Modeling;mouse model;Mus;mutant;Mutant Strains Mice;Mutate;Mutation;Neoplasm Metastasis;new therapeutic target;novel therapeutics;Oncogenic;overexpression;patient derived xenograft model;PDL1 pathway;PDPK1 gene;personalized approach;Phosphorylation;Phosphotransferases;PIK3CG gene;Play;predicting response;programmed cell death ligand 1;Protein-Serine-Threonine Kinases;Receptor Protein-Tyrosine Kinases;Resistance;response;Role;Serine;Signal Pathway;Signal Transduction;Site;Solid;success;Testing;therapeutic target;Threonine;transcription factor;Trastuzumab;tumor;tumor growth;tumor microenvironment;tumor progression;tumor xenograft;tumorigenesis;Tumorigenicity;United States;Xenograft procedure

PROJECT_TITLE: Role of Erbb3 kinase activity in colorectal tumorigenesis.

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Gut integrity is markedly worsened following sepsis, the leading cause of death among critically ill patients. Cancer is the most common comorbidity in sepsis, and the presence of malignancy results in significant alterations in both immunity and gut integrity. This program seeks to understand mechanisms through which sepsis alters gut integrity and through which cancer worsens outcomes in order to uncover new potential therapeutic targets to improve outcomes in a disease that is very common and highly lethal.

PI_NAMEs: COOPERSMITH, CRAIG M (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Adaptive Immune System;Antibiotic Therapy;Antibiotics;Apoptosis;bench to bedside;beneficiary;Blood;Cause of Death;Chronic;Clinical;Clinical Data;comorbidity;cost;Critical Illness;Disease;Distant;Elements;Epithelium;experimental study;Feces;Functional disorder;General Population;Goals;high risk;Human;Immunity;improved outcome;In Vitro;in vivo;Individual;insight;Intestines;Malignant Neoplasms;Medicare;microbiome;migration;Morbidity - disease rate;mortality;mortality risk;Motor;Mucosal Immune System;Multiple Organ Failure;Organ;Outcome;Patients;Permeability;Play;precision medicine;Process;programs;Proliferating;Public Health;Role;Sampling;Sepsis;septic patients;Supportive care;Syndrome;Techniques;Therapeutic;therapeutic target;United States;young adult

PROJECT_TITLE: The Gut as a Target to Improve Outcomes in Sepsis

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE. Key aging-related immune system changes (immunosenescence) combined with chronic, low-level inflammation states, termed inflamm-aging, have been increasingly related to neurodegenerative changes, both in the central nervous system and peripherally. The aim of this proposal is to combine advanced statistical methods and a systems biology modeling approach with high-throughput omics markers (blood-based epigenetics and metabolomics) to study immune system aging in neurodegenerative disease (AD and PD) patients relative to community-based controls. And importantly, relate markers of heightened immune states and faster inflamm- aging to longitudinal disease progression, including symptom development and multiple metabolomics measurements over time.

PI_NAMEs: PAUL, KIMBERLY  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Acceleration;adaptive immune response;Adaptive Immune System;age related changes;Aging;aging related;aging related disease;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Amyloid beta-Protein;Atrophic;Award;Biological;Biological Aging;Biological Markers;biological systems;Biology;Blood;Brain;Brain Diseases;brain morphology;career;career development;Cell Lineage;Cells;Central Nervous System;Cerebrospinal Fluid;Chronic;cohort;Communities;Complex;cytokine;Data;Data Analyses;Data Science;Dementia;design;Development;Development Plans;Disease;Disease Outcome;Disease Progression;DNA Methylation;Doctor of Philosophy;Environmental Exposure;epidemiologic data;Epidemiologist;Epidemiology;epidemiology study;epigenetic clock;epigenetic marker;Epigenetic Process;Exhibits;fluorodeoxyglucose positron emission tomography;Foundations;Funding;Gene set enrichment analysis;Genes;genetic architecture;genome wide association study;Genomics;Goals;Immune;immune activation;Immune signaling;Immune system;immune system function;Immunologic Markers;immunosenescence;Impaired cognition;Inflammaging;Inflammation;Innate Immune Response;Innate Immune System;innovation;insight;Knowledge acquisition;Lead;Leadership;Learning;Leukocytes;Link;Measurement;Measures;Mediating;medical schools;Mentors;Metabolic dysfunction;Metabolic Pathway;metabolic profile;Metabolism;metabolome;metabolomics;Methods;methylation biomarker;Modeling;Modernization;National Institute of Environmental Health Sciences;Nerve Degeneration;Neurodegenerative Disorders;neurodegenerative phenotype;Neurologic;Neurology;Outcome;Parkinson Disease;Pathogenesis;Pathway interactions;Patients;Peripheral;Population Research;Population Sciences;Population Study;Postdoctoral Fellow;Process;professor;Proliferating;Public Health Schools;Research;Research Personnel;Research Priority;Resource Development;Resources;response;Risk;Risk Factors;Role;Science;Serum;skills;small molecule;Statistical Methods;Symptoms;System;Systems Biology;tau Proteins;Technology;Time;tool;Training;Training Support;Variant;Work

PROJECT_TITLE: Immune System Aging in Parkinson’s and Alzheimer’s disease: Epigenetics, biologic aging, and heightened immune states in a population-based study

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Biological Aging Study Section[NIA-B]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECTIVE NARRATIVE The objective of this grant is to study the detailed molecular and cellular mechanisms by which chronic exposure to stimulant and opioid drugs of abuse alters specific types of neurons within the brain's reward circuitry. We focus on changes at the chromatin—or epigenetic—level as mediators of particularly long-lasting effects of drug administration. These studies will provide new information concerning how drugs of abuse cause a state of addiction as well as identify novel leads toward the development of improved diagnostic tests and treatments.

PI_NAMEs: NESTLER, ERIC J. (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: Acetylation;addiction;Affect;Architecture;ATAC-seq;Award;Behavior;Behavioral;Biological Assay;Brain;brain reward regions;candidate identification;cell type;Cells;ChIP-seq;Chromatin;chromatin modification;Chromatin Structure;Chronic;Cicatrix;Cocaine;cocaine self-administration;Cocaine withdrawal;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cyclic AMP-Responsive DNA-Binding Protein;Data Set;Deposition;desensitization;Development;Diagnostic tests;Dissection;Dopamine D2 Receptor;Dose;Down-Regulation;Drug Addiction;drug craving;Drug Exposure;drug of abuse;Drug Regulations;drug relapse;Drug Stability;Enhancers;Epigenetic Process;epigenetic regulation;Exposure to;FOS Protein;Funding;Gene Expression;Gene Expression Regulation;Gene Transfer;Genes;Genetic Transcription;genome-wide;genomic locus;Grant;GTP-Binding Proteins;Heroin;histone methyltransferase;Histones;improved;Incubated;knock-down;Knowledge;large datasets;Maps;Mediating;Mediator;Methods;Modeling;Molecular;Mus;Neurons;novel;Nuclear Proteins;Nucleosomes;Nucleus Accumbens;Opioid;opioid abuse;Pathway interactions;Pattern;Pharmaceutical Preparations;Play;Proteins;Proteomics;psychostimulant;Publishing;receptor;Regulation;response;reward circuitry;Rewards;RNA;Rodent Model;Role;Saline;Self Administration;Signal Pathway;Signal Transduction;Stimulant;stimulant exposure;Time;transcription factor;transcriptome sequencing;Up-Regulation;Variant;Viral;Withdrawal;Work

PROJECT_TITLE: Molecular Studies of Cocaine Action in Brain

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: Project Narrative The overall goal of this fellowship is to provide advanced training in resuscitation science research to junior physician-scientists and PhD-scientists. Resuscitation focuses on common yet highly lethal conditions such as cardiac arrest (i.e., heart no longer beating and requiring CPR), shock, and acute respiratory distress syndrome (ARDS, difficulty with breathing/oxygenation), therefore impacting the lives of millions of people each year. Our program will address a current shortage of investigators in this critically important discipline by providing high-quality research and career development training for the next generation of resuscitation scientists.

PI_NAMEs: DONNINO, MICHAEL WILLIAM (contact);MITTLEMAN, MURRAY A

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Resuscitation;Science;Training Programs

PROJECT_TITLE: Training Program in Resuscitation Science

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ORG_CITY: Newark

ORG_DEPT: PEDIATRICS

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Narrative: There is a significant, unmet need to develop new interventions against systemic fungal infections, which account for ~1.5 million deaths annually. Collaborative studies in the Rivera and Xue labs recently identified a novel, highly immunogenic vaccine strain of Cryptococcus neoformans that showed potent heterologous protection against multiple invasive mycoses. In this application, we will employ this vaccine candidate strain to uncover immune mechanisms of vaccine-induced cross-protection with a focus on pulmonary innate immunity.

PI_NAMEs: RIVERA, AMARILIZ  (contact);XUE, CHAOYANG

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affect;Alveolar Macrophages;anti-fungal agents;Aspergillosis;Aspergillus fumigatus;Cells;Cessation of life;Clinical;Critical Pathways;cross immunity;Cryptococcosis;Cryptococcus gattii;Cryptococcus neoformans;cytokine;Data;Death Rate;Defect;Development;Drug resistance;Embryo;Epigenetic Process;Exhibits;Exposure to;Fungal Vaccines;fungus;Future;Gene Targeting;Genetic Transcription;Health;Host Defense Mechanism;IFNAR1 gene;Immune;Immunity;Immunization;Immunocompromised Host;immunogenic;Immunosuppression;improved;In Vitro;in vivo;Infection;Infection Control;Inflammation;insight;Interferons;Intervention;Life;Literature;loss of function;Lung;Lung infections;lung pathogen;Macrophage;Mediator;Medical;Molds;monocyte;mortality;Mus;Mycoses;Natural Immunity;neutrophil;novel;Opportunistic Infections;pathogen;pathogenic fungus;Pathway interactions;Patient-Focused Outcomes;Patients;Phagocytes;Pharmaceutical Preparations;Population;Predisposition;Publishing;Recording of previous events;Regulation;response;Role;Shapes;Siblings;Signal Transduction;Source;STAT1 gene;Stimulus;Systems Biology;T-Lymphocyte;Testing;Therapeutic;Tissues;Training;vaccine candidate;Vaccines

PROJECT_TITLE: Trained immunity and the regulation of anti-fungal defense


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PUBLIC HEALTH RELEVANCE/NARRATIVE Liver cancer is one of the most virulent cancers in the world (2nd leading cause of cancer-related death in the world). The overall goal of this proposal is to uncover roles of PEA15 in liver cancer development and test if PEA15 is good therapeutic target. Our approach will pave the way to develop novel strategy for treatment of liver cancer.

PI_NAMEs: LEE, JU-SEOG  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Ablation;Accountability;Accounting;Aftercare;angiogenesis;Angiogenesis Inhibitors;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Apoptosis;Automobile Driving;BAY 54-9085;Biological Assay;Cancer Center;Cancer Etiology;cancer therapy;cancer type;cell growth;Cell model;Cell Physiology;Cessation of life;Clinical;Collaborations;cost;curative treatments;Data;Death Rate;design;Development;Disease;Disease Pathway;Disease Progression;Down-Regulation;drug efficacy;Drug Targeting;efficacy evaluation;Eligibility Determination;Epigenetic Process;Excision;experimental study;Failure;Gene Expression Profiling;Genetic;Genome;genomic data;glucose metabolism;Goals;Growth;hepatocellular carcinoma cell line;HIF1A gene;human data;improved;Incidence;Invaded;kinase inhibitor;Knowledge;liver development;Malignant Breast Neoplasm;Malignant Epithelial Cell;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mediating;Mediator;Mesenchymal;Molecular;molecular subtypes;mortality;mouse model;Mutagenesis;novel;novel strategies;novel therapeutic intervention;Oncogenic;Outcome;overexpression;Pathogenesis;Pathway interactions;Patient Care;patient derived xenograft model;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Phase III Clinical Trials;Phenotype;Pilot Projects;predictive marker;Primary carcinoma of the liver cells;Prognosis;prognostic;Proliferating;Proteins;Proteomics;Public Health;public health relevance;Regulation;Research;Resistance;response;Role;standard of care;Survival Rate;targeted agent;Testing;Therapeutic;therapeutic target;therapeutically effective;Time;Transplantation;Treatment Efficacy;treatment strategy;tumor;tumor growth;understudied cancer;United States;VEGFC gene;Virulent;Work

PROJECT_TITLE: PEA15 IN DEVELOPMENT OF LIVER CANCER AND ITS THERAPEUTIC IMPLICATION


NIH_SPENDING_CATS: Immunotherapy

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: RELEVANCE / PROJECT NARRATIVE Remarkable progresses have been made by checkpoint inhibition, metabolic reprogramming, and vaccination to enhance the properties of immune cells for immunotherapy, however, glycan engineering to achieve the same goal is just started to be explored. Given the critical roles of LacNAc, fucose and sialic acid in immune modulation, a deeper understanding of how these glycans are regulated and involved in receptor interaction may aid the development of new therapeutic modalities to treat autoimmune disease and cancer. We expect that such modalities may be combined with currently FDA-approved therapeutic agents, such as anti-PD-1 and anti-CTLA-4 based immune checkpoint inhibitors, to achieve better response rate in patients.

PI_NAMEs: WU, PENG  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Affinity;anti-CTLA4;anti-PD-1;Autoimmune Diseases;Binding;Binding Proteins;Biological Process;Cell Communication;Cell Physiology;Cell surface;Cells;checkpoint inhibition;cytokine;cytotoxic;Development;Disease Progression;Engineering;Environment;exhaustion;FDA approved;Fucose;Genome;Glycoconjugates;Glycoproteins;glycosylation;glycosyltransferase;Goals;human disease;Immune;immune activation;Immune checkpoint inhibitor;Immune signaling;Immune System Diseases;Immunoglobulins;immunoregulation;Immunotherapy;In Situ;interest;Label;Lectin;Ligands;Malignant Neoplasms;Mediating;Metabolic;Methods;Modality;Modification;Molecular;Molecular Biology Techniques;Monosaccharides;N-acetyllactosamine;Natural Killer Cells;novel;novel therapeutics;Oligosaccharides;Organism;Patients;Polysaccharides;Production;Proliferating;Property;receptor;receptor binding;Recombinants;response;Role;sialic acid binding Ig-like lectin;Sialic Acids;sialylation;Signal Transduction;Specificity;Structure;sugar nucleotide;T-Lymphocyte;Therapeutic Agents;tool;Tumor Immunity;Vaccination;Visualization

PROJECT_TITLE: Chemoenzymatic glycan editing for deciphering biological functions of glycans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: BALTIMORE

ORG_DEPT: BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Through this work, I will use an optical reporter assay that I have designed in larval zebrafish to explore the spatiotemporal metabolic gene response to high levels of dietary triglycerides, as well as the regulatory relationship between dietary triglyceride absorption and lipoprotein production/secretion. The optical tools that I develop and the regulatory sequences that I annotate will provide many additional avenues for interrogation of triglyceride metabolic pathway components as they relate to cardiovascular disease, diabetes, obesity, and other metabolic diseases.

PI_NAMEs: BIEDERMAN, MICHELLE  (contact)

PROGRAM_OFFICER_NAME: BODDIE, THOMAS ARTIS

PROJECT_TERMS: absorption;Animal Model;Animals;apolipoprotein A-IV;Apolipoproteins;Apolipoproteins A;Apolipoproteins B;Behavioral;Biological Assay;Body System;Cardiovascular Diseases;Cell Nucleus;Cell Physiology;cell type;Cells;Cholesterol;Chylomicrons;Complex;Confocal Microscopy;Cultured Cells;Data;Dependence;design;Development;Diabetes Mellitus;dietary;Dietary Fats;Dietary Fatty Acid;Dietary Practices;dietary requirement;Engineering;Enterocytes;experimental study;Fatty acid glycerol esters;Fatty Liver;feeding;Fluorescence;Future;gastrointestinal system;Gene Expression;Genes;Genetic;Genetic Transcription;genomic locus;Heart Diseases;High Fat Diet;Homeostasis;Human;Hydrophobicity;Individual;Inflammation;Insulin;Intestines;Knowledge;Larva;Link;lipid metabolism;lipid transfer protein;Lipids;Lipoproteins;Liver;Location;Low-Density Lipoproteins;Measurement;Measures;Mediating;Membrane;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic Pathway;Metabolism;microbial;microbiota;microsomal triglyceride transfer protein;Mus;mutant;Nutrient;Nutrient availability;Nutritional;Obesity;Optical reporter;Optics;Organ;overexpression;particle;Pathway interactions;pharmacologic;Phospholipids;Plasma;Production;Proteins;Regulation;Reporter;Reporter Genes;Research;response;Satiation;screening;Signal Transduction;single-cell RNA sequencing;Site;Small Intestines;small molecule;spatiotemporal;System;Techniques;Testing;Time;Tissues;tool;transcription factor;Transgenic Organisms;Triglycerides;uptake;Very low density lipoprotein;Visualization;Work;Zebrafish

PROJECT_TITLE: Localization and regulation of metabolic gene expression in response to dietary triglycerides


ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Using a unique set of human specimens from families with high rates of prostate cancer, we have identified new gene mutations that might explain why prostate cancer risk is heritable. Now, we will test whether these mutations disrupt protein functions, disrupt DNA repair in cell culture, and increase cancer risk in mouse models. These insights will impact the field by increasing the availability of biomarkers for early diagnosis and providing molecular targets for anti-cancer drug development.

PI_NAMEs: SHEN, BINGHUI  (contact);SUN, ZIJIE

PROGRAM_OFFICER_NAME: LIU, ZHIHUI

PROJECT_TERMS: androgen independent prostate cancer;Androgen Receptor;androgen sensitive;Androgens;Antineoplastic Agents;Biochemistry;Biological;Blood specimen;Cancer Etiology;Cancer Family;cancer genetics;cancer initiation;cancer risk;Cell Culture Techniques;Cell Cycle Checkpoint;Cells;Cellular biology;Cities;Collection;Coupled;Data;Defect;design;Development;Disease susceptibility;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Disorder;DNA Repair Gene;DNA Repair Pathway;Double Strand Break Repair;drug development;early detection biomarkers;Early Diagnosis;endonuclease;Ensure;Evaluation;Excision;exome sequencing;experience;experimental study;Family;Gene Mutation;gene product;gene repair;Genetic;genetic approach;genetic architecture;Genetic Transcription;genome integrity;Genome Stability;Genomic Instability;Germ-Line Mutation;Goals;helicase;Heritability;Human;Impairment;In Vitro;Inherited;innovation;insight;Link;loss of function;Malignant - descriptor;Malignant neoplasm of prostate;Malignant Neoplasms;Medical center;Missense Mutation;Molecular;Molecular Target;mouse genetics;mouse model;Mus;Mutate;Mutation;Nebraska;Neoplastic Cell Transformation;Nonhomologous DNA End Joining;novel;nuclease;Oncogenic;overexpression;Pathway interactions;Poly(ADP-ribose) Polymerase Inhibitor;prevent;Prostate;prostate cancer risk;prostate carcinogenesis;Prostatic;protein function;receptor expression;Receptor Signaling;recruit;Regimen;repaired;Research;Resected;response;Risk;Risk Estimate;Risk Factors;risk variant;Role;Sampling;Site;Specimen;Stress;Susceptibility Gene;System;targeted sequencing;Testing;Therapeutic;Tissues;Topoisomerase;tumor progression;tumorigenesis;Universities;Validation;Virulence Factors;Work

PROJECT_TITLE: DNA repair gene mutations and prostate cancer

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric Cancer;Post-Traumatic Stress Disorder (PTSD);Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Telehealth

ORG_CITY: WILMINGTON

ORG_NAME: NEMOURS CHILDREN'S HOSPITAL, DELAWARE

ORG_STATE: DE

PHR: It is critical to provide accessible evidence-based psychosocial support to parents and caregivers of children with cancer (PCCC) in order to mitigate individual and family-level psychosocial risks. This effectiveness trial evaluates an eHealth intervention for English- and Spanish-speaking (PCCC) with study endpoints focused on decreasing negative psychosocial sequelae (acute distress, posttraumatic stress, and anxiety) and improving coping abilities (coping self-efficacy, cognitive coping strategies). The long-term goal of this research program is to sustain and disseminate an effective, scalable, high-reach, and cost-effective intervention to provide crucial support to PCCC across the pediatric cancer trajectory.

PI_NAMEs: CANTER, KIMBERLY  (contact)

PROGRAM_OFFICER_NAME: ACEVEDO, AMANDA MARIE

PROJECT_TERMS: acceptability and feasibility;Acute;acute symptom;Address;Anxiety;Behavioral;cancer care;cancer survival;caregiver interventions;Caregivers;Caring;Childhood;Childhood Cancer Treatment;Clinical;Cognitive;Collaborations;Communities;Consent;Consolidated Framework for Implementation Research;coping;Coping Skills;cost;cost effective intervention;cost estimate;Cost Savings;COVID-19 pandemic;Data;design;Development;Dissemination and Implementation;Distress;Education;effectiveness trial;efficacy evaluation;efficacy testing;eHealth;Electronics;eligible participant;Emotional;evidence base;Family;flexibility;follow-up;Future;Goals;Grant;health care disparity;Health Personnel;Health Services Accessibility;Immigration;Impairment;implementation cost;implementation strategy;improved;Individual;innovation;interest;Internet;Intervention;intervention delivery;intervention participants;intervention program;intervention refinement;Interview;Language;Latino;Latino Population;Limited English Proficiency;Literature;low socioeconomic status;Malignant Childhood Neoplasm;Malignant Neoplasms;Medical;Mental Depression;Modeling;Newly Diagnosed;novel;Nursing Staff;Oncology;Outcome;parenting intervention;Parents;Participant;Pattern;Pediatric Oncology;Persons;Phase;pilot test;Population;Positioning Attribute;post intervention;post-traumatic stress;post-traumatic symptoms;Predictive Factor;Predisposition;Process;programs;protective factors;psychosocial;Psychosocial Assessment and Care;psychosocial outcome;Randomized, Controlled Trials;Recommendation;reduce symptoms;Research;Research Personnel;Risk;Risk Factors;Role;secondary endpoint;Self Direction;Self Efficacy;Site;social;sociodemographics;Spanish;Spanish/English;stressor;Symptoms;System;telehealth;Testing;Therapeutic;tool;trial comparing;uptake;web site

PROJECT_TITLE: A randomized controlled trial of eSCCIP: An eHealth psychosocial intervention for English and Spanish speaking parents of children with cancer

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Clinical Research;Hematology;Physical Injury - Accidents and Adverse Effects

ORG_DEPT: EMERGENCY MEDICINE

PHR: PROJECT NARRATIVE  This project is aimed at improving the outcomes of trauma patients by developing a deeper understanding of a common and deadly bleeding disorder that arises after serious injury. The investigator will pursue several promising lines of inquiry to characterize in detail the mechanisms underlying platelet dysfunction and microvas- cular blood flow disturbance in this disorder. The project will also provide training for the candidate to develop a unique and advanced skill set and launch an independent research career to continue this work.

PI_NAMEs: ST. JOHN, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Acetylcysteine;acronyms;Actins;ADAMTS;Adhesions;Adhesiveness;Adhesives;Affect;Animal Model;Binding;Blood;Blood Coagulation Disorders;Blood flow;Blood Platelets;Blood specimen;Blood Vessels;Brain Injuries;burden of illness;career;Career Mobility;Cause of Death;Cell membrane;Cessation of life;Clinical;Complex;Complication;Consumption;contrast enhanced;Data;Defect;Deposition;Diagnosis;Diagnostic;disability-adjusted life years;Disease;Disintegrins;empowerment;Endothelial Cells;experimental study;Fibrin split products;Fibrinogen;Functional disorder;Gelsolin;Goals;Hemorrhage;Hemostatic function;Imaging Device;Impairment;improved;improved outcome;in vivo;injured;Injury;insight;Integrins;Investigation;Knowledge;knowledge base;Lead;Learning;Ligands;Link;Malignant Neoplasms;Measurement;Measures;Mechanics;member;Mentors;Metalloproteases;Microcirculation;Modeling;Morbidity - disease rate;mortality;multidisciplinary;Myocardial Ischemia;Outcome;oxidation;Oxidative Stress;Pathway interactions;Patients;Peptide Hydrolases;Perfusion;Plasma;Platelet Activation;Platelet Adhesiveness;Platelet aggregation;platelet function;polymerization;Polymers;preventable death;Process;Professional Competence;Proteins;Rattus;receptor;Research;Research Personnel;Sampling;Scientist;severe injury;Shock;skills;Structure;Surface;Syndrome;Techniques;Testing;Therapeutic Intervention;Thrombosis;Thrombospondins;Thrombus;Tissues;Training;Trauma;trauma induced coagulopathy;Trauma patient;Ultrasonography;ultrasound;United States;von Willebrand Factor;Work

PROJECT_TITLE: Dysregulation of Platelet-von Willebrand Factor Interaction in Trauma-Induced Coagulopathy

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Orphan Drug;Prevention;Rare Diseases

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE This project’s goal is to produce knowledge about how the immune system causes two different but related forms of uveitis (inflammation in the eye) that affect people all over the world. Uveitis can cause blindness, low quality of life, and high economic cost. Successful completion of this research may help to develop treatments that can be tailored to specific patients based on genetic testing, with more focused, foreseeable, and powerful effects against uveitis than current forms of treatment.

PI_NAMEs: NOWATZKY, JOHANNES  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Acute;Affect;Alleles;Anterior uveitis;Autoimmunity;Autologous;Behcet's eye disease;Binding;Blindness;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell surface;Cells;Clonal Expansion;Cloning;CRISPR/Cas technology;Data;Disease;disorder control;economic cost;economic impact;effector T cell;Endoplasmic Reticulum;enzyme activity;Epitopes;Etiology;experimental study;Eye;gene therapy;Generations;Genetic Epistasis;Genetic Polymorphism;genetic testing;genome editing;Genotype;Goals;Haplotypes;Health;High Prevalence;high risk;HLA-B Antigens;HLA-B27 Antigen;HLA-Bw51;Human;Immune response;Immune system;Immune System Diseases;Immunity;Immunogenetics;immunogenic;immunogenicity;Inflammation;Insertional Mutagenesis;Knowledge;Ligands;Literature;Mediating;Molecular Target;Outcome;Pathogenesis;Pathogenicity;Pathologic;patient subsets;Patients;Peptides;Persons;pharmacologic;Prediction of Response to Therapy;prevent;Psoriasis;Psoriatic Arthritis;Publishing;Quality of life;Research;Risk;Series;T cell response;targeted treatment;therapeutic target;therapy design;Uveitis;Variant;Viral Antigens

PROJECT_TITLE: Modulation of immunodominance in HLA class I associated uveitides

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Mental Health;Neurosciences

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PI_NAMEs: CHEN, XIAOMO  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Address;Affect;Attention;Attention deficit hyperactivity disorder;Attentional deficit;Behavior;Behavioral;Brain;Child;cognitive control;cognitive function;cognitive process;Decision Making;Delayed Memory;density;Dependence;Diagnosis;Disease;Dissociation;Dopamine;Dopamine D1 Receptor;Dopamine D2 Receptor;Dopamine Receptor;Feedback;Health;Homologous Gene;Human;improved;Learning;Mediating;Motor;Motor Activity;multi-electrode arrays;neural;neural circuit;neurofeedback;neuromechanism;Neurons;nonhuman primate;Parietal Lobe;Patients;Pharmacologic Substance;Play;Population;Prefrontal Cortex;Primates;Process;Protocols documentation;receptor;Rewards;Rodent;Role;Schizophrenia;selective attention;Sensory;Stimulus;technique development;Testing;Visual;Visual attention;visual control;Visual Cortex;visual processing;visual stimulus

PROJECT_TITLE: Interacting neural mechanisms of selective visual attention and value-based decision-making

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Disability Research;Neurodegenerative;Neurosciences;Prevention;Rehabilitation

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: The over 44 million persons worldwide living with dementia are primarily older adults with Alzheimer’s Disease (AD) or related dementias (ADRD). The consequences of physical disability and death from ADRD combined with uncertain clinical benefit of AD treatments motivate the search for targets of preventive intervention. We hypothesize that biomarkers of aging are related to cognitive and physical decline long before dementia and physical disability and are the source of modifiable biological mechanisms; thus, we propose to harmonize data from over 11,000 older adults with measured biomarkers to develop and disseminate statistical methods to identify potential biological aging-related targets of intervention to prevent ADRD and physical disability.

PI_NAMEs: SHARDELL, MICHELLE DENISE (contact)

PROGRAM_OFFICER_NAME: KWOK, RICHARD K

PROJECT_TERMS: Address;Adult;Affect;Age;age related;aged;Aging;aging biomarker;aging mechanism;aging related;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;biobank;Biological;biological adaptation to stress;biological age;Biological Aging;Biological Markers;Biology of Aging;biomarker identification;Body System;candidate marker;Cell Aging;Cell Communication;Cell Physiology;Cessation of life;circulating biomarkers;Clinical;Code;Cognition;Cognitive;cognitive performance;cohort;Cohort Studies;Communities;Data;data harmonization;data sharing;Dementia;disability;Disease;early detection biomarkers;Early identification;epidemiology study;Epigenetic Process;Event;extend lifespan;GDF15 gene;Geroscience;Goals;Guide prevention;hallmarks of aging;Health;high dimensionality;Human;human old age (65+);improved;Individuals with physical disabilities;Inflammation;innovation;Interleukin-6;Intervention;Joints;Kidney;Knowledge;Longitudinal Studies;Measures;metabolomics;method development;Methods;Mitochondria;Modeling;Molecular;motor control;Musculoskeletal;Musculoskeletal System;Neurologic;novel;novel marker;Nutrient;older adult;Outcome;Pathology;Persons;Physical Performance;physically handicapped;post gamma-globulins;prevent;Prevention;Prevention trial;preventive intervention;Process;Proteins;Proteomics;proteostasis loss;Public Health;Research;Risk;Risk Factors;risk prediction;Signal Transduction;Source;Statistical Methods;Statistical Models;Structural Models;Telomere Shortening;Testing;therapeutic target;Time;TNF gene;tool;Work

PROJECT_TITLE: Methods to Test Biomarkers of Aging as Shared Determinants of Alzheimers Disease and Related Dementias and Physical Disability

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-J(02)M]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative The proposed research and training will allow Dr. Alana Biggers to obtain critical research skills and study a mindfulness meditation program designed to improve sleep and reduce stress in African-American adults with diabetes. If effective, this program may reduce the risk of cardiovascular disease among African-Americans with type 2 diabetes who are at high risk of cardiovascular disease.

PI_NAMEs: BIGGERS, ALANA  (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Address;Adult;African American;African American population;American;Attention;attentional control;Behavior;behavioral health;Behavioral Research;biological adaptation to stress;Biological Markers;Blood Pressure;C-reactive protein;cardiometabolic risk;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular effects;cardiovascular risk factor;career;Caring;Chronic;Chronic Disease;Chronic Insomnia;Chronic stress;comparison control;Data Analyses;Data Collection;design;diabetes control;Diabetes Mellitus;diabetes self-management;Disease;Educational Curriculum;emotion regulation;Evaluation;follow-up;glycemic control;Glycosylated Hemoglobin;Goals;Grant;group intervention;Health Disparities Research;health disparity;high risk;Home;Hyperactivity;hypothalamic pituitary axis;improved;improvement on sleep;Inflammation;Inflammatory;Institution;Interleukin-6;Intervention;Intervention Studies;knowledge base;Life Style;Lipids;Longitudinal Studies;Mediating;Mentorship;Metabolic dysfunction;Methodology;Methods;mHealth;mindfulness;mindfulness meditation;Mindfulness Training;Minority Groups;mortality;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Participant;perceived stress;Persons;Physicians;Pilot Projects;poor sleep;Population;primary outcome;programs;Psychological Stress;Randomized, Controlled Trials;Recommendation;Reporting;Research;Research Design;Research Methodology;Research Personnel;Research Training;Risk;Risk Behaviors;Risk Factors;Risk Reduction;Self Perception;skills;Sleep;Sleep Disorders;sleep health;sleep quality;sleep regulation;Sleeplessness;Socioeconomic Status;Stress;stress management;stress reduction;stressor;Text Messaging;TNF gene;Training;Work

PROJECT_TITLE: My ESSENCE - Mindfulness to Reduce Stress, Improve SIeep, and Reduce Cardiovascular Risk in African-Americans with Type 2 Diabetes


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Public Health Relevance Statement: Understanding how the brain processes sounds is important to the well being of everyone in the society. Findings of the present study will contribute to our understanding of neural mechanisms underlying hearing in the brain. They will have important implications for understanding human hearing mechanisms in both normal and pathological conditions.

PI_NAMEs: WANG, XIAOQIN  (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Anatomy;Animals;Area;Arousal;Auditory area;Auditory system;awake;Behavioral;Biological Models;Brain;Calcium;Callithrix;Callithrix jacchus jacchus;Code;Complex;density;Disease;Exhibits;Experimental Models;Funding;Grant;Hearing;hearing range;Human;Image;Imaging Techniques;information processing;Knowledge;Laboratories;Lateral;Literature;Location;Maps;Modeling;Music;neural;neural circuit;neuromechanism;Neurons;neurophysiology;Noise;nonhuman primate;novel;optical imaging;Pathologic;Pathway interactions;Personal Satisfaction;Physiological;Preparation;Primates;Process;Property;public health relevance;Publishing;receptive field;Research;response;Response Latencies;Sampling;Societies;sound;Speech;Stimulus;Techniques;Testing;Transgenic Organisms;two-photon;Vision;Visual Cortex;vocalization;Work

PROJECT_TITLE: Information Processing in Auditory Cortex

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: We will examine the therapeutic specificity and efficacy of antisense oligonucleotide targeting a neuron-specific protein kinase on suppression of the phosphorylation and accumulation of tau protein, a pathological hallmark of Alzheimer’s disease. This reagent will be administered into animal models of Alzheimer’s disease and human neuronal cells derived from Alzheimer’s and tauopathy patient induced pluripotent stem cells. The successful completion of the study will lead to the development of a novel nucleic acid-based therapeutics by targeting neuron-specific kinase.

PI_NAMEs: IKEZU, SEIKO  (contact)

PROGRAM_OFFICER_NAME: GROTHAUS, PAUL G

PROJECT_TERMS: Affect;Age Months;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Animal Model;Antisense Oligonucleotides;Arctic Regions;Autopsy;Axon;axonal degeneration;behavior test;Biochemistry;Brain;brain tissue;Catalytic Domain;CDK5 gene;Cell Line;Cells;Central Nervous System;Chinese;cilium biogenesis;Clinical Trials;cognitive function;cohort;comparison control;Control Groups;cross reactivity;Data;Dementia;Dependovirus;Development;drug development;effective therapy;efficacy evaluation;entorhinal cortex;Episodic memory;experimental study;frontal lobe;FTD with parkinsonism;Functional Magnetic Resonance Imaging;Future;Goals;hippocampal pyramidal neuron;Hippocampus;Human;human induced pluripotent stem cells;Immunohistochemistry;Impaired cognition;In Vitro;in vivo;in vivo evaluation;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;Injections;kinase inhibitor;Knock-in;Knowledge;Late Onset Alzheimer Disease;Link;Medial;Mediator;Memory impairment;mild cognitive impairment;Mitosis;Modeling;mouse model;Mus;Mutation;Nerve Degeneration;neuron loss;Neurons;neuropathology;novel;nucleic acid-based therapeutics;Nucleic Acids;Odds Ratio;Organoids;Pathogenesis;Pathogenicity;Pathologic;Pathology;patient derived induced pluripotent stem cells;Patients;Persons;Phosphorylation;Phosphotransferases;Play;protein expression;Protein Kinase;Publishing;Reagent;Reporting;response;Role;safety assessment;Semaphorin-3A;Senile dementia;Site;Spanish;Specificity;Spinocerebellar Ataxias;stem cell model;Structure;Swedish mutation;System;tau aggregation;tau dysfunction;tau expression;tau mutation;tau Proteins;tau-1;tau-protein kinase;tau-tubulin kinase;Tauopathies;Temporal Lobe;Testing;Tg2576;Therapeutic;Therapeutic Effect;therapeutic evaluation;Therapeutic Intervention;therapeutic target;Thioflavin S;tool;transcriptome sequencing;Transgenic Mice;Transgenic Organisms

PROJECT_TITLE: Therapeutic evaluation of targeting Tau Tubulin kinase-1 in Alzheimer’s disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Precision Medicine;Radiation Oncology;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative: Tumors release microvesicles called exosomes that reflect the protein content of the tumor itself. We will develop methods using a universal internal standard(UIS) for highly reproducible quantitative analysis of the protein content of exosomes from patient serum during a course of treatment with chemotherapy and radiation therapy. This method will be applied to a set of exosome protein markers from prior work for monitoring changes in protein cargo after treatment via a targeted mass spec-based approach.

PI_NAMEs: LUBMAN, DAVID M. (contact);SHI, TUJIN

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Address;advanced disease;advanced pancreatic cancer;Aftercare;Amino Acids;assay development;Biological Assay;Biological Markers;biomarker identification;biomarker panel;biomarker validation;Blood;Cancer cell line;Cancer Etiology;cancer therapy;cancer type;Cell Culture Techniques;Cell Line;Cell secretion;Cessation of life;chemoradiation;chemotherapy;Chemotherapy and/or radiation;Clinical;cohort;Combination Drug Therapy;Detection;Diameter;Disease;Early identification;Early treatment;exosome;Future;high standard;Human;imaging modality;improved;individual patient;Knowledge;Label;Liquid Chromatography;Local Therapy;Malignant neoplasm of pancreas;Mass Chromatography;Mass Spectrum Analysis;Measurement;Membrane;Methods;microvesicles;minimally invasive;Monitor;multiplex assay;nanosized;Nature;neoplastic cell;Normal Cell;novel;novel marker;pancreatic cancer cells;pancreatic cancer patients;Patient-Focused Outcomes;Patients;Performance;Population;Preparation;Prognosis;Progression-Free Survivals;Prospective cohort;Protein Analysis;protein biomarkers;Proteins;Proteomics;Radiation therapy;Reproducibility;Research;response;Sampling;Serum;Serum Markers;Stable Isotope Labeling;standard of care;Survival Rate;Therapeutic;tool;Toxic effect;Treatment outcome;treatment response;tumor;Unresectable;Variant;Vesicle;Work;X-Ray Computed Tomography

PROJECT_TITLE: Universal Internal Standard for Reproducible Accurate Quantification of Exosome Protein Markers

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Nashville

ORG_DEPT: PHYSIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative: Alzheimer’s disease (AD) is a progressive neurodegenerative disease and the leading cause of dementia in the United States. Unfortunately, there is no cure for AD, and drug discovery for AD has suffered significant failures. In this application we aim to identify and validate drugs that are approved for other diseases to treat AD, via genetics, electronic health records and human iPSC models.

PI_NAMEs: LI, BINGSHAN  (contact);WEI, WEI-QI ;WEN, ZHEXING

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: Affect;Age;Algorithms;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;apolipoprotein E-4;Astrocytes;Biological Assay;Biological Process;candidate identification;candidate validation;Cell Death;Cell Line;cell type;Clinical;Clinical Trials;Code;cohort;Combined Modality Therapy;comorbidity;computer framework;cytokine;Data;Dementia;Development;Diagnostic;Disease;drug development;drug discovery;drug repurposing;Drug Targeting;Drug usage;drug use screening;Early Onset Alzheimer Disease;efficacy testing;Electronic Health Record;Electronics;Etiology;Failure;FDA approved;Gender;Gene Expression Profile;Gene Expression Profiling;gene network;Genes;Genetic;genetic architecture;Genetic study;genome wide association study;genomic data;Goals;Heritability;high throughput screening;Human;human induced pluripotent stem cells;Impaired cognition;Individual;induced pluripotent stem cell;innovation;Late Onset Alzheimer Disease;Microglia;Mitochondria;Modeling;Morphology;mouse model;Multiomic Data;Mutation;Natural Language Processing;Neurodegenerative Disorders;Neurons;novel;Oxidative Stress;Pathogenesis;Pathologic;Pathway interactions;patient derived induced pluripotent stem cells;Pharmaceutical Preparations;Phenotype;phenotyping algorithm;Positioning Attribute;presenilin-1;prevent;Production;Race;Recording of previous events;Role;screening;sex;single cell sequencing;stem cell model;Structure;success;Synapses;tau-1;Text;transmission process;United States;Validation;virtual

PROJECT_TITLE: Drug repositioning for Alzheimer's disease via genetics, electronic health records, and human iPSC models


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Pain Research;Rare Diseases;Vector-Borne Diseases;Zika Virus

ORG_CITY: GAINESVILLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Relevance Statement  A point-of-care (POC) testing platform capable of detecting Zika virus (ZIKV), dengue virus (DENV), chikungunya virus (CHIKV), and Mayaro virus (MAYV) infection can be useful for diagnosing symptomatic patients, screening asymptomatic public in the infected area, and monitoring possible virus transmission.

PI_NAMEs: FAN, Z. HUGH (contact)

PROGRAM_OFFICER_NAME: DYALL, JULIE

PROJECT_TERMS: Ache;Address;Affect;amplification device;Anxiety;Arboviruses;Area;Arthralgia;Authorization documentation;Bacterial Infections;Benchmarking;Biological Assay;Blood;Blood specimen;Brazil;Caribbean region;Centers for Disease Control and Prevention (U.S.);chikungunya infection;Chikungunya virus;Clinic;Clinical;clinical care;Clinical Management;Clinics and Hospitals;Coin;cost;Country;Cytolysis;Dengue;Dengue Infection;Dengue Shock Syndrome;Dengue Virus;design;Detection;detection platform;detection sensitivity;Devices;Diagnosis;Diagnostic;diagnostic platform;disability;Disease Outbreaks;DNA Primers;emerging virus;Enzyme-Linked Immunosorbent Assay;Epidemic;epidemic potential;Exanthema;Fever;Florida;General Population;Genetic;Goals;Haiti;Headache;Human;Human Resources;improved;Infant;Infection;innovation;interest;isothermal amplification;joint inflammation;Laboratories;Latin America;Life;Link;Mayaro virus;Mediating;Medical;Methods;Microcephaly;Monitor;mosquito-borne;Mothers;multiplex detection;Neurologic Deficit;Newborn Infant;Nucleic Acids;operation;Paper;pathogen;Patients;Performance;point of care;point of care testing;point-of-care diagnostics;Polymerase Chain Reaction;Population;population based;Pregnancy;Preparation;Process;Public Health;Recommendation;Reporting;Research;Reverse Transcription;RNA;RNA amplification;RNA Viruses;Saliva;saliva sample;Sampling;screening;Serotyping;Specificity;Symptoms;Syndrome;Testing;Urine;vector mosquito;viral detection;viral transmission;virtual;Virus;Virus Diseases;World Health Organization;Zika Virus;ZIKV infection

PROJECT_TITLE: Multiplexed Detection of Mosquito-Borne Viruses at the Point-of-Care

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Genetics;Harm Reduction for Substance Misuse;Lung;Neurosciences;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Substance Misuse

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: RELEVANCE TO PUBLIC HEALTH The proposed research is relevant to public health because the characterization of the variable response to opioids is expected to advance our understanding of the mechanisms that underlie opioid overdose through respiratory depression eventually leading to the development of alternative opioid overdose reversal agents as well as through prediction of individuals in whom opioids are contraindicated due to overdose vulnerability. Thus, the proposed research is relevant to the NIH's mission to develop fundamental knowledge that will help to reduce the burdens of human disability and death. This proposal addresses the notice by the Division of Neuroscience and Behavior of NIDA (June 25, 2018) to give high programmatic priority to opioid-related basic research.

PI_NAMEs: BUBIER, JASON A (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: Absence of pain sensation;Acute;addiction;Address;Basic Science;Behavior;Binding;Biological;Blood gas;Brain Stem;Central Nervous System;Cessation of life;Chromosome Mapping;Collection;Complex;Development;disability;Drug Exposure;Epidemic;Euphoria;Feeling;Fentanyl;Future;Gene Expression;Genes;Genetic;genetic approach;Genetic Variation;genomic locus;Goals;Human;Individual;Individual Differences;individual variation;innovation;inter-individual variation;Knowledge;Maps;Measures;Medial;Mediating;Medical emergency;Methods;Mission;Modeling;Molecular;Morphine;Mus;Naloxone;National Institute of Drug Abuse;network models;Neurons;Neurosciences;novel;Opioid;opioid abuse;Opioid agonist;Opioid Antagonist;opioid epidemic;opioid overdose;Opioid Receptor;opioid withdrawal;Outcome;Overdose;overdose death;overdose prevention;Overdose reversal;overdose risk;Pain management;Pathway interactions;Patients;Peripheral Nervous System;pharmacologic;Phenotype;Physiological;Plethysmography;Population;Predisposition;prescription opioid;prevent;Public Health;Quantitative Trait Loci;Recovery;remediation;Research;respiratory;Respiratory Center;response;Sedation procedure;side effect;synthetic opioid;Therapeutic;Time;trait;transcriptome;transcriptomic profiling;translational impact;treatment response;United States;United States National Institutes of Health;Variant;Ventilatory Depression

PROJECT_TITLE: Genetic Variation in Opioid Induced Respiratory Depression in Mice

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ORG_STATE: CA

PHR: Overcoming metastasis and resistance to chemotherapies remains a major unmet need for colorectal cancer (CRC). We propose to gain a precise understanding of the molecular mechanisms by which lipids promote CRC metastasis and resistance to current therapies, followed by developing novel and effective approaches to control chemo-resistance and tumor progression.

PI_NAMEs: ANN, DAVID K.;YU, HUA E (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: ABCB1 gene;Acetyl Coenzyme A;Acetylation;Acyl Coenzyme A;Adipocytes;Anabolism;Apoptosis;Biogenesis;BRAF gene;cancer cell;Catabolism;CD36 gene;CD44 gene;Cell Survival;Cells;Chemoresistance;chemotherapy;Clinical;clinical translation;Coenzyme A Ligases;colon cancer patients;Colorectal Cancer;colorectal cancer metastasis;colorectal cancer prevention;colorectal cancer progression;Data;Diet;DNA Sequence Alteration;Drug resistance;Event;Family member;Fatty acid glycerol esters;fatty acid oxidation;Fatty Acids;Goals;in vivo evaluation;inhibitor;insight;lipid transport;Lipids;long chain fatty acid;Malignant Neoplasms;Mediating;Membrane Potentials;Metabolic;Metabolism;metastatic colorectal;Mitochondria;mitochondrial membrane;Molecular;Multi-Drug Resistance;Mus;Mutate;Mutation;Nature;Neoplasm Metastasis;neoplastic cell;novel;novel strategies;Obesity;Oncogenic;Outcome;oxidation;Pathway interactions;patient derived xenograft model;Patients;Penetration;Peptides;Pharmaceutical Preparations;Phospholipids;Play;Prognosis;Publishing;Pump;receptor;Refractory;Resistance;Role;Site;STAT3 gene;stemness;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;therapy resistant;Tissues;triple-negative invasive breast carcinoma;tumor;tumor initiation;tumor microenvironment;tumor progression;Tumor Promotion;tumor xenograft;uptake;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Fatty acids and their receptors-mediated tumor metastasis and progression

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Cardiovascular;Lung;Social Determinants of Health

ORG_CITY: EAST LANSING

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: Project Narrative: Relevance to Public Heath Lack of representation of minorities, financially disadvantaged, and disabled individuals in the biomedical research and healthcare workforce has been identified as a critical factor underlying widespread human health disparities. Important to such human health research are comparative studies and investigations using animal models, which are routinely conducted by veterinarians; unfortunately the racial and ethnic diversity in the veterinary profession is no better than that of the biomedical research workforce in general. This research education program is designed to increase the number of undergraduate and veterinary medical students from underserved populations who pursue advanced education and careers in biomedical research in the fields of heart, lung, or blood diseases.

PI_NAMEs: CONTRERAS, GENARO ANDRES;EWART, SUSAN L (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Active Learning;Advisory Committees;Airway Disease;Animal Model;Area;Biomedical Research;Blood Cells;Books;career;Career Choice;Clinical Research;college;Committee Members;Communities;community building;Comparative Study;Data;demographics;design;Development;Disabled Persons;Disease;Disparity;Disparity population;Education;education planning;education research;Educational workshop;effectiveness evaluation;Ensure;Environment;ethnic diversity;Evaluation;experience;Exposure to;Faculty;Feedback;Fostering;Goals;Health;health care availability;health disparity;Health Sciences;Healthcare;Heart Diseases;Hematological Disease;Human;Hypertension;improved;Individual;innovation;Institution;Instruction;interest;Investigation;Knowledge;Lung Diseases;Medical;Medical Students;Mentors;Mentorship;Michigan;Minority;Mission;National Heart, Lung, and Blood Institute;next generation;online resource;Outcome;Participant;Pathology;peer networks;Population;programs;Public Health;racial diversity;Reading;recruit;Reduce health disparities;Research;Research Personnel;research study;response;responsible research conduct;Science;Scientist;Social Sciences;Societies;student participation;Students;Study models;success;summer research;Tissues;Training;undergraduate student;Underrepresented Populations;Underrepresented Students;Underserved Population;Universities;university student;Veterinarians;Work

PROJECT_TITLE: Increasing Diversity in Experiential Research Education at Michigan State University


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative This study will provide valuable information about the effects of stereotype threat on brain functions and the relation of these stress-related effects to alcohol misuse. We will thus obtain a novel understanding of the neurobehavioral mechanisms associated with alcohol misuse in adults. This research will build the necessary groundwork for future studies that aim to reduce and prevent alcohol misuse.

PI_NAMEs: CLARK, URAINA S. (contact)

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: Addictive Behavior;Adult;Affect;Affective;African American;African American population;Alcohol consumption;alcohol measurement;alcohol misuse;alcohol misuse prevention;alcohol response;alcohol risk;alcohol use disorder;Alcohols;American;Anterior;Behavior;Behavioral;Brain;Brain region;Cirrhosis;Clinical;clinically relevant;cognitive control;cognitive process;Communities;Cues;Data;Decision Making;Dependence;design;discounting;disorder risk;drinking behavior;Environment;Environmental Risk Factor;European;Exhibits;experience;Exposure to;follow-up;Frequencies;Functional Magnetic Resonance Imaging;Future;Goals;Impulsivity;Individual;innovation;insight;Intervention;Knowledge;Life;Measures;Mediating;Methods;mortality;National Institute on Alcohol Abuse and Alcoholism;Nature;neural;neural correlate;neurobehavioral;neuromechanism;novel;novel strategies;Participant;prevent;Prevention strategy;programs;promote resilience;Public Health;Race;racial population;Randomized;Research;Rest;Risk Behaviors;social;social culture;social determinants;social factors;Stereotyping;Stigmatization;Stimulus;Stress;stressor;substance use;Substance Use Disorder;System;therapy development;verbal;Visit

PROJECT_TITLE: Effects of Stereotype Threat on Impulsivity and Its Relation to Alcohol Use in African Americans: An fMRI Study

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Transplantation

PHR: Project Narrative  This proposal addresses fundamental limitations in current corneal transplant surgery by developing an artificial intelligence guided compact robotic surgical tool that could empower corneal surgeons to achieve difficult surgical objectives, reduce intraoperative complications, and improve clinical outcomes when performing Deep Anterior Lamellar Keratoplasty (DALK). Further, these capabilities are broadly applicable in other microsurgical problems, and the tools will enable further advances both for ophthalmology and for other microsurgical disciplines.

PI_NAMEs: KANG, JIN U (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Accounting;Address;Adrenal Cortex Hormones;Animal Model;Anterior;Artificial Intelligence;Blindness;Blunt Trauma;Burr hole procedure;Cadaver;Clinical;Compensation;Complication;Consumption;convolutional neural network;Cornea;Corneal Diseases;Corneal dystrophy;Corneal Opacity;corneal scar;curative treatments;Data;deep learning;Descemet's membrane;design;Devices;Discipline;Distal;Drops;Early Diagnosis;empowerment;Endophthalmitis;Endothelial Cells;Endothelium;Engineering;Ensure;Epithelium;Excision;experience;Expert Systems;Eye;Eye Surgeon;Failure;Fiber Optics;Geometry;Glaucoma;Goals;graft failure;Graft Survival;Hemorrhage;high risk;Human;iatrogenic injury;Image;Immune;improved;in vivo;Incidence;Infection;Injections;instrument;interest;Intraoperative Complications;Iris;Keratoconus;Keratoplasty;Laboratories;Lamellar Keratoplasty;Manuals;mechanical drive;Medical;microrobot;Microscope;Microsurgery;Modeling;Motion;Movement;Needles;novel;Ocular Hypertension;Operative Surgical Procedures;Ophthalmology;Optical Coherence Tomography;Optics;Oryctolagus cuniculus;Outcome;Pathological Dilatation;Patients;Penetrating Keratoplasty;Perforation;Performance;phantom model;photonics;Postoperative Complications;Postoperative Period;preservation;Procedures;prototype;Ptosis;Recovery;Repeat Surgery;Reporting;Research Personnel;Risk;Robotics;Rupture;Safety;Scientist;Secondary to;sensor;skills;Structure;Surgeon;surgery outcome;Surgical complication;System;Systems Development;Techniques;Technology;Testing;Thick;Time;Tissues;tool;Topical Corticosteroids;Translating;Transplantation Surgery;Trauma;Validation;Visual;Visual Acuity;Visualization;Work

PROJECT_TITLE: Artificial intelligence Optical Coherence Tomography Guided Deep Anterior Lamellar Keratoplasty (AUTO-DALK)


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: SEATTLE

ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

PHR: Patients with multiple chronic health conditions (i.e., multimorbidity) and their primary care providers (PCPs) must deal with numerous, often competing health concerns. With many competing health concerns, focusing healthcare on the outcomes patients prefer can help avoid burdensome, unwanted, or harmful care. This project develops an intervention (Vet-Align) to align what Veterans with multimorbidity find meaningful and their preferred health outcomes with the routine clinical care provided by PCPs. This study clarifies Veteran perspectives on how what is meaningful in life affects their health decisions, designs an evidence-informed tool and pathways to guide Veterans and PCPs in making health decisions consistent with Veteran-preferred health outcomes, and tests the intervention’s acceptability and feasibility for patients and staff at two VA primary care clinics. This research promotes a person-centered care approach for Veterans with multimorbidity by aligning care with what matters most to patients, with long-term potential to improve care quality and patient engagement.

PI_NAMEs: SCHUTTNER, LINNAEA  (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;adverse event risk;Affect;Benchmarking;career;Caring;Chronic;Chronic Disease;Clinic;Clinic Visits;Clinical;clinical care;Clinical effectiveness;Clinical Practice Guideline;Clinical Trials;clinically actionable;Complex;cost;Decision Analysis;Decision Making;design;Diagnostic tests;Disease;Effectiveness;Eligibility Determination;experience;Feedback;Foundations;Future;Goals;Guidelines;Health;Health Priorities;Health system;Healthcare;high risk;Home;Hour;human centered design;implementation strategy;improved;Individual;individual patient;innovation;Intervention;Interview;Leadership;Life;Link;Methodology;Methods;Modeling;multiple chronic conditions;novel;Outcome;Outpatients;Pathway interactions;Patient Care;Patient Care Planning;Patient Compliance;patient engagement;patient oriented;Patient Outcomes Assessments;Patient-Centered Care;Patient-Focused Outcomes;Patients;person centered;personalized care;Physicians;pilot test;poor health outcome;Prevalence;Primary Care;primary care clinic;primary care provider;primary care team;Process;Prognosis;provider communication;psychosocial;Quality of Care;randomized, clinical trials;Recommendation;reduce symptoms;Research;Research Personnel;Resources;Role;Self Management;Service delivery model;Services;skills;skills training;Specificity;Structure;Symptoms;Testing;Time;tool;Translating;Triage;Trust;Veterans;Veterans Health Administration;wasting;whole health

PROJECT_TITLE: Integrating personal values into primary care for Veterans with multimorbidity

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Eye Disease and Disorders of Vision;Mental Health;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative This project aims to understand the neural mechanisms underlying spatial and nonspatial knowledge. The information gained from this research will be important for developing rehabilitation strategies in people with impaired sight, who often suffer from wayfinding difficulties. Moreover, because the brain regions that support spatial and nonspatial knowledge are involved in several kinds of memory, information about these systems is important for mitigating the memory problems and navigational challenges that occur when these systems are impacted by normal aging, stroke, and neurodegenerative diseases such as Alzheimer's dementia.

PI_NAMEs: EPSTEIN, RUSSELL A (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Address;Alzheimer's Disease;Animals;Architecture;Articulation;Behavior;behavior measurement;Behavioral;behavioral study;Brain;Brain region;Cells;Cities;Code;Cognition;Cognitive;cognitive function;cognitive neuroscience;Cognitive Science;Complex;Coupled;Elements;Environment;Episodic memory;experimental study;Fire - disasters;Functional Magnetic Resonance Imaging;Future;Graph;Grouping;Head;Hippocampal Formation;Human;Imagination;Impairment;Individual;Individual Differences;Investigation;Knowledge;Life;Location;Maps;Mediating;Memory;mental representation;Methods;Mind;Nature;Neighborhoods;neural;neural correlate;Neurocognitive;Neurodegenerative Disorders;neuroimaging;neuromechanism;Neurons;neurophysiology;normal aging;operation;Pattern;Persons;Play;Process;prospective;Psyche structure;Psychologist;Recording of previous events;rehabilitation strategy;Research;Rodent;Role;Route;Scientist;Self-Help Devices;Semantic memory;Semantics;spatial memory;spatial relationship;Stroke;Structure;Support System;System;Techniques;Testing;theories;Thinking;Traction;Vision;Visuospatial;way finding;Work

PROJECT_TITLE: Spatial and nonspatial knowledge

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Nutrition;Prevention

ORG_CITY: CLEVELAND

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE Non-alcoholic fatty liver disease (NAFLD) is a burgeoning public health crisis that is projected to affect nearly 25% of the global population, and may soon become the leading indication for liver transplantation. The role of S-nitrosylation in this disease is poorly understood. The goal of this study is to probe the role of S-nitrosylation in NAFLD through genetic and pharmacologic modulation of the denitrosylase enzyme AKR1a1 in order to better understand its role in the pathophysiology of this disease and to identify AKR1a1-regulated enzymes as potential therapeutic targets.

PI_NAMEs: VENETOS, NICHOLAS  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Ablation;Acetyl-CoA Carboxylase;Acute Renal Failure with Renal Papillary Necrosis;Affect;Amino Acids;Animals;ATP Citrate (pro-S)-Lyase;Attenuated;Body Weight;Cell Culture Techniques;Cells;Choline Deficiency;Coenzyme A;Coupled;CRISPR/Cas technology;Cysteine;Data;Diet;diet-induced obesity;dietary;Dietary Administration;Disease;Drug Targeting;effective therapy;Enzymes;Equilibrium;Etiology;Family;Fatty acid glycerol esters;Fatty Liver;Functional disorder;Genetic;genome editing;Goals;Guidelines;Hepatic;Hepatocyte;High Fat Diet;Human body;Impairment;in vivo;Incidence;inhibitor;insight;Intervention;Isotopes;knock-down;Knock-out;Knockout Mice;Label;lipid biosynthesis;lipid metabolism;Lipids;Liver;Liver diseases;liver transplantation;Mass Spectrum Analysis;Mediating;member;Modeling;Modification;mouse model;NADP;new therapeutic target;Nitric Oxide;Nitric Oxide Synthase;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Obesity;Oxidoreductase;Pathogenesis;Pathogenicity;Pathway interactions;Patients;pharmacologic;Pharmacological Treatment;Phenotype;Physiological;Plant Resins;Population;prevent;Prevention;Prevention therapy;Primary carcinoma of the liver cells;problem drinker;progression risk;protective effect;Protein S;Proteins;Public Health;Recommendation;Regulation;Resistance;restoration;Role;S-Nitrosothiols;Signal Transduction;Site-Directed Mutagenesis;small molecule;small molecule inhibitor;Steatohepatitis;Sulfhydryl Compounds;Techniques;therapeutic target;Tissues;Viral;Wild Type Mouse

PROJECT_TITLE: AKR1a1 as a novel therapeutic target for Non-Alcoholic Fatty Liver Disease


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Genetics;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

PHR: PROJECT NARRATIVE The dopamine receptor DRD2 antagonist and mitochondrial protease ClpP agonist ONC201 has shown early clinical efficacy in patients with diffuse midline glioma harboring H3K27M mutation (H3K27M-DMG); but we do not know how to improve responses in resistant tumors. In our preliminary data, ONC201 activity is dependent on ClpP activity and resistance correlates with high expression of EGFR and the brain developmental transcription factor FOXG1. The proposed research will determine the impact of EGFR and FOXG1 signaling on H3K27M-DMG bioenergietcs, and the ability of EGFR/FOXG1 modulation to impact ONC201-induced mitochondrial stress in H3K27M-DMG.

PI_NAMEs: KOSCHMANN, CARL J (contact)

PROGRAM_OFFICER_NAME: FOUNTAIN, JANE W

PROJECT_TERMS: Adult;Agonist;antagonist;Apoptosis;Binding;Bioenergetics;Brain;Brain Stem;Breast Cancer Cell;cancer cell;Cell Death;cell type;Cells;Child;Clinical;Clinical Data;clinical efficacy;clinical predictors;combinatorial;Combined Modality Therapy;Data;Databases;Development;diffuse midline glioma;DNA Binding;Dopamine D2 Receptor;Dopamine Receptor;DRD2 gene;EGFR inhibition;Epidermal Growth Factor Receptor;FOXG1B gene;Genes;Genetic;Genetic Transcription;Genomics;Glioma;glioma cell line;Glycolysis;H3 K27M mutation;Histones;Human;Immunohistochemistry;improved;In Vitro;in vivo;Induction of Apoptosis;International;knock-down;Location;Malignant Neoplasms;Mediating;Metabolic Pathway;Mitochondria;Modeling;Molecular;Mus;Mutation;neoplastic cell;nerve stem cell;Outcome;Oxidative Phosphorylation;Pathway interactions;patient population;Patients;Peptide Hydrolases;Phase;Phenotype;Progression-Free Survivals;Radiation;Reporting;Research;Resistance;response;Role;Signal Transduction;Site;Stains;Stress;Subgroup;Thalamic structure;Therapeutic;TNF-related apoptosis-inducing ligand;transcription factor;Translations;tumor;Work;young adult

PROJECT_TITLE: Targeting EGFR/FOXG1-mediated resistance to ONC201 in H3K27M-mutant diffuse midline glioma

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: MH

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Neurosciences

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: NARRATIVE Overgeneralization of negative memories often precedes and predicts the development of depression and other affective disorders, and is recognized as a major cause of the recurrence and severity of such disorders. We propose to study the neurobiology of negative memory generalization with a view to understanding how cellular and circuit-based techniques could be used to mitigate the harmful effects of overgeneralization.

PI_NAMEs: RADULOVIC, JELENA  (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: Acetylcholine;Affect;Affective Symptoms;aversive conditioning;Behavior;behavioral response;Brain;cholinergic;Code;Cognitive deficits;Cues;Data;design;Development;diagnostic criteria;Disease;Dorsal;Episodic memory;episodic memory impairment;experience;experimental study;Female;Fiber;Foundations;Fright;Future;Genetic;Global Change;Hippocampus;Immediate-Early Genes;Impaired cognition;Impairment;Label;Magnetic Resonance Imaging;Major Depressive Disorder;male;Manganese;Measurement;Medial;Mediating;Memory;memory encoding;memory retrieval;Mental Depression;Mood Disorders;Mus;Negative Valence;Neuroanatomy;Neurobiology;Neurons;neuroregulation;novel;NPAS4 gene;optogenetics;Photometry;Play;Population;Process;promoter;Recurrence;Retrieval;Review Literature;Role;Scopolamine;Severities;Signal Transduction;social stress;Source;stem;Stress;stress reduction;Stressful Event;System;Techniques;Testing;translational impact;Ventral Tegmental Area;Visualization

PROJECT_TITLE: Mechanisms of Stress-Enhanced Aversive Conditioning

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Kidney Disease;Precision Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Relevance: The molecular mechanisms of nephrotic syndrome (NS) and other glomerular diseases is unknown. The studies proposed will examine the role of genetic defects in RCAN1 and other genes in the calcineurin signaling pathways in the pathogenesis of NS, identify predictors of response to calcineurin inhibitors, and new therapeutic targets for NS.

PI_NAMEs: GBADEGESIN, RASHEED ADEBAYO (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: Apoptosis;Biological Markers;biomarker identification;Biotechnology;Calcineurin;Calcineurin inhibitor;Calcineurin Pathway;Cells;cellular targeting;Chronic Kidney Failure;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;cost;Custom;Cytoskeleton;Data;Defect;Diagnostic;diagnostic tool;Disease;Disease remission;Drug Targeting;Economics;effective therapy;Family;Genes;Genetic;Genetic Determinism;Genetic Predisposition to Disease;Genetic Transcription;genome sequencing;Heterozygote;Homeostasis;Individual;induced pluripotent stem cell;inhibitor;inhibitor therapy;Injury;Kidney;kidney biopsy;Kidney Diseases;Knowledge;Mediating;Molecular;multi-ethnic;mutant;Mutation;Nephrotic Syndrome;nephrotoxicity;new therapeutic target;next generation sequencing;noninvasive diagnosis;novel;Organoids;Participant;Pathogenesis;Pathogenicity;Pathologic;Patient Care;patient derived induced pluripotent stem cells;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;podocyte;predicting response;Prediction of Response to Therapy;Prevalence;Process;Protein Dephosphorylation;Proteins;rare variant;Regulator Genes;Renal glomerular disease;response;response biomarker;Role;screening;segregation;side effect;Signal Pathway;Signal Transduction;Steroid-resistant idiopathic nephrotic syndrome;success;targeted treatment;Testing;Therapeutic;therapeutic target;Toxic effect;transcriptomics;treatment response;United States;Variant;whole genome

PROJECT_TITLE: REGULATORS OF CALCINEURIN PATHWAYS AS DIAGNOSTIC AND THERAPEUTIC TARGETS FOR NEPHROTIC SYNDROME

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative The Georgetown University Initiative for Maximizing Student Development (IMSD) will expand the diversity of our PhD student population, build a community of interdisciplinary scholars, facilitate career self-efficacy, and establish a community of practice in inclusive mentorship. We will welcome a yearly cohort of PhD students from underrepresented backgrounds, from across 7 PhD programs on the Georgetown Main and Medical Center campuses, train them in foundational research skills and experimental design, and set them up with faculty mentoring teams. We will provide our students with cross-departmental and cross-sector skills training and professional experiential learning opportunities, and facilitate their growth as near peer mentors. Trainees will transition into their thesis research projects empowered with a sustained network of professional resources and interdisciplinary scientific skills to prepare them for broad careers in the scientific workforce.

PI_NAMEs: MAGUIRE-ZEISS, KATHLEEN ANNE (contact);MCKINNEY, CALEB ;ROLFES, RONDA J

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Development;Students;Universities

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]