NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Brain Disorders;Epilepsy;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative The proposed research is relevant to public health because it will unravel the mechanisms by which a novel protein complex disrupts neuronal function, resulting in severe and debilitating neurodevelopmental consequences, including intellectual disability, epilepsy and autism. Thus, the proposed research is relevant to the NIH’s mission of supporting fundamental research that will ultimately cure disease.

PI_NAMEs: GRONENBORN, ANGELA M.;THOMAS, GARY  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Acetylation;Affect;alpha Tubulin;Animals;Antisense Oligonucleotides;autism spectrum disorder;Behavior;behavior test;Behavioral;Binding;Biochemical;Biochemistry;biophysical analysis;Biophysics;Catalytic Domain;Cellular biology;Centrosome;Cilia;Client;Complex;Contacting Client;Coupled;curative treatments;Data;Deacetylase;Deacetylation;Dendrites;Development;Disease;Dynein ATPase;effective therapy;Electroencephalography;Electrophysiology (science);Endosomes;Enzyme Inhibitor Drugs;Enzymes;Epilepsy;flexibility;fundamental research;genome integrity;Goals;Golgi Apparatus;HDAC6 gene;hippocampal pyramidal neuron;Impairment;inhibitor therapy;innovation;insight;Intellectual functioning disability;Intervention;live cell imaging;Maintenance;Membrane Protein Traffic;Methodology;Microtubules;Missense Mutation;Mission;Modeling;Molecular;Motor;mouse model;Mus;Mutation;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;neuron development;Neuronal Dysfunction;Neurons;neurotransmission;novel;Organelles;PACS1 Syndrome;Pathway interactions;patient derived induced pluripotent stem cells;Patients;pharmacologic;Phenotype;Physiological;Positioning Attribute;postsynaptic;premature;protein complex;Protein Sortings;protein transport;Proteins;Public Health;Recurrence;Regulation;Research;Seizures;Signal Pathway;Signaling Molecule;Slice;Structure;Synapses;Synaptic Transmission;Testing;Therapeutic;therapeutic RNA;tool;trafficking;trans-Golgi Network;translational framework;United States National Institutes of Health;Whole Organism

PROJECT_TITLE: Molecular, Cellular and Behavioral Impact of the R203W PACS1 Syndrome Mutation

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: VA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: PALO ALTO

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

ORG_STATE: CA

PHR: Volumetric muscle loss (VML) is caused by the loss of a large portion of skeletal muscle due to traumatic injury, leading to permanent muscle damage. The incidence of VML is becoming more frequent in Veterans as a result of combat. The goal of this proposal is to bioengineer muscle that mimics normal muscle and blood vessel structure as a new strategy to treat VML. The engineered muscle utilizes nano-patterned scaffolds to organize the muscle precursor cells and endothelial cells along their normal arrangement to mimic native muscle structure. The engineered muscle will be tested in mice with VML to test its therapeutic benefit. The proposed studies are highly significant because they seek to improve the health of Veterans suffering from VML using bioengineered muscle.

PI_NAMEs: HUANG, NGAN F. (contact)

PROJECT_TERMS: Ablation;bioluminescence imaging;Biomedical Engineering;Blood;blood perfusion;Blood Vessels;Cell Density;Cell fusion;Cell Line;Cell Survival;Cell Transplantation;Cicatrix;Clinical;Coculture Techniques;combat;confocal imaging;Cues;cytokine;Data;Debridement;design;Disease;DNA Sequence Alteration;Economic Burden;Endothelial Cells;Endothelium;Engineering;experience;Explosion;Extracellular Matrix;Gene Delivery;Generations;Goals;Growth;Growth Factor;Gunshot wound;healing;Health;Histologic;Impairment;improved;In Vitro;in vivo;Incidence;injured;Injury;Lasers;Length;Long term disability;Measurement;Measures;mechanical properties;Mediating;Messenger RNA;military veteran;Morbidity - disease rate;mouse model;mRNA delivery;Mus;Muscle;muscle engineering;Muscle Fibers;Muscle function;muscle physiology;muscle regeneration;muscle strength;Muscular Atrophy;muscular structure;Myoblasts;nanofibrillar;nanopattern;nanoscale;Natural regeneration;novel strategies;Operative Surgical Procedures;Outcome;Oxygen;Patients;Pattern;Perfusion;Physiological;Play;Proteomics;Recovery;repaired;revascularization;Role;scaffold;Site;Skeletal Muscle;Spectrum Analysis;Structure;Supplementation;System;Testing;Therapeutic;tibialis anterior muscle;Tissue constructs;Tissue Engineering;Tissues;Transfection;Transplantation;transplantation therapy;Traumatic injury;Treatment Efficacy;Vascular Endothelial Cell;Vascular regeneration;Vascularization;Vehicle crash;Veterans;volumetric muscle loss

PROJECT_TITLE: Engineering Vascularized Skeletal Muscle for Treatment of Volumetric Muscle Loss


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: Los Alamos

ORG_NAME: TRIAD NATIONAL SECURITY, LLC

ORG_STATE: NM

PHR: PROJECT NARRATIVE We will characterize PD-1 immune checkpoint signaling dynamics in T cells by using quantitative mass spectrometry-based phosphoproteomics, single-molecule fluorescence microscopy, bioinformatics, and mechanistic mathematical modeling. A better basic understanding of PD-1 signaling, which plays an important role in avoidance of autoimmunity and escape of cancer cells and pathogens from immune surveillance, has the potential to motivate evaluation of new therapeutic strategies for diverse diseases.

PI_NAMEs: HLAVACEK, WILLIAM S (contact);LIDKE, DIANE ;NAEGLE, KRISTEN M

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Accounting;adaptive immune response;Affinity;Antibodies;Antigen Presentation;Antigen-Presenting Cells;Antigens;arm;Autoimmune Diseases;Autoimmunity;B7-DC antigen;Bioinformatics;Biological Assay;cancer cell;CD28 gene;CD8-Positive T-Lymphocytes;CD80 gene;CD86 gene;Cell Line;Cells;Chronic;chronic infection;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;Data;Data Analyses;dectin 1;Disease;dynamic system;Engineering;Evaluation;exhaustion;experimental study;Family;Fluorescence Microscopy;Formulation;Human;Immune;immune activation;immune checkpoint;Immune response;Immune system;Immune Targeting;Immunologic Surveillance;Immunotherapy;improved;Individual;Innate Immune Response;interest;Intervention;Investigation;ITAM;Knowledge;Label;Ligands;machine learning prediction;Mass Spectrum Analysis;mathematical model;Measurement;Measures;Mediating;Membrane;Methods;Modeling;Molecular;Monitor;neoplastic cell;novel therapeutic intervention;NR0B2 gene;Oncology;particle;pathogen;pathogenic fungus;Pattern;phosphoproteomics;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphorylation Site;Phosphotransferases;Phosphotyrosine;Play;Population;predictive modeling;predictive test;prevent;programmed cell death ligand 1;programmed cell death protein 1;Protein Dephosphorylation;Protein Tyrosine Kinase;Protein Tyrosine Phosphatase;Proteins;Protocols documentation;PTPN11 gene;PTPN6 gene;Reagent;receptor;Receptor Inhibition;Receptor Signaling;recruit;response;Role;Sampling;segregation;Signal Transduction;Signaling Protein;single molecule;Site;Structure;SYK gene;Systems Biology;T cell therapy;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Techniques;Testing;Therapeutic antibodies;Time;Toll-like receptors;Tyrosine Phosphorylation;Validation;Western Blotting;ZAP-70 Gene

PROJECT_TITLE: System Dynamics of PD-1 Signaling in T Cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-R(02)M]


ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: PA

PHR: Traumatic brain injury (TBI) is one of the most common casualties in military personnel. Mild TBI accounts for over 80% of all TBI incidents in the active military service members and experiences unrelenting progression of neurocognitive, behavioral and psychiatric deficits. The long-lasting traumatic axonal injury, loss of myelin sheath, and inhibition of oligodendrocyte maturation contribute to motor, cognitive, behavioral, and psychiatric deficits. This proposal will investigate the roles of microglia-oligodendrocyte interactions in white matter injury and tissue repair in experimental TBI models and explore glia-oriented therapeutic strategies for treating TBI.

PI_NAMEs: SUN, DANDAN  (contact)

PROJECT_TERMS: Acceleration;Affect;Axon;axon injury;Behavioral;Black race;Brain;Cells;Cessation of life;Cognitive;controlled cortical impact;Cre-LoxP;cytokine;Data;Demyelinations;Dendritic Spines;density;Exhibits;experience;Flow Cytometry;Fluorescence;Free Radicals;Gold;Homeostasis;Impairment;improved;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injury;injury and repair;Ischemic Stroke;Knock-out;Knockout Mice;Knowledge;Latex Bead;LoxP-flanked allele;Macrophage;Measurement;Mediating;Microglia;mild traumatic brain injury;Military Personnel;military service;Modeling;Motor;Mus;Myelin;Myelin Sheath;myelination;NADPH Oxidase;Nervous System Physiology;Neurocognitive;Neuroglia;Neurologic;Neurons;oligodendrocyte progenitor;Oligodendroglia;Phagocytes;Phagocytosis;pharmacologic;Phenotype;Pilot Projects;Population;preservation;Production;Proliferating;Protein Isoforms;Proteins;Recovery of Function;Regulation;remyelination;repaired;Reporting;Role;Sensorimotor functions;service member;spatiotemporal;Stains;stem cells;Stroke;stroke model;Structure;Superoxides;Synapses;TBI Patients;Testing;Therapeutic;therapeutic target;tissue repair;transcriptome;transcriptome sequencing;Transmission Electron Microscopy;Traumatic Brain Injury;Traumatic Brain Injury recovery;uptake;Veterans;Western Blotting;white matter;white matter injury;Wild Type Mouse

PROJECT_TITLE: Microglia in White Matter Repair after TBI


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE: Relevance to public health This program will encourage students to enter healthcare and research careers in the neurosciences, addressing the predicted need for such professionals due to an aging population in the United States. By also encouraging students from underrepresented minorities in these fields to participate, the program addresses the need to develop diversity in the neurosciences specifically, both in healthcare and in research.

PI_NAMEs: ELLENBOGEN, RICHARD GLEN (contact);MACDONALD, CHRISTINE L

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Achievement;Address;Age;aging population;Award;Awareness;Basic Science;Biomedical Research;career;Child;Clinical;clinical application;clinical practice;Clinical Research;college;Communication;Communities;Community Medicine;Doctor of Philosophy;early awareness;Education;education research;empowerment;Engineering;Environment;Ethics;Evidence Based Medicine;experience;Faculty;First Generation College Students;Focus Groups;Fostering;Foundations;Funding;Future;Goals;health care delivery;health care disparity;Healthcare;Healthcare Systems;Hispanic Americans;improved;Indigenous;Individual;Interdisciplinary Study;interest;knowledge base;Laboratories;Latino Population;Low income;marginalized population;Mathematics;Medical;Medical Education;medical schools;Medicine;member;Mentors;Mentorship;Mexican Americans;Migrant;Minority Groups;Mission;multidisciplinary;Native Americans;neural;Neurosciences;Neurosciences Research;Neurosurgical Procedures;operation;Operative Surgical Procedures;outreach program;Participant;Pathway interactions;Positioning Attribute;Process;programs;Public Health;Readiness;recruit;Reporting;Research;Research Institute;role model;Rural;Schools;Science;Scientist;skills;Societies;STEM field;Student Selections;Students;success;summer research;Surgeon;symposium;synergism;System;Translating;translational neuroscience;Translational Research;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;Underrepresented Students;United States;Universities;Vision;Vocation;Washington;Woman;Work

PROJECT_TITLE: Summer Research Experience in Translational Neuroscience and Neurological Surgery


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Kidney Disease

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE  While approximately 450,000 patients in the United States are treated with life-sustaining maintenance hemodialysis for end-stage renal disease, their mortality rate is unacceptably high, reaching approximately 50% by three years from the time of hemodialysis initiation. Rates of cardiovascular morbidity and mortality, including sudden cardiac death, are higher on the days of dialysis and have been associated with higher serum and dialysate bicarbonate concentrations. Our proposal will explore the effect of altering the dialysate bicarbonate on intradialytic hypotension and electrocardiographic changes associated with sudden cardiac death.

PI_NAMEs: RAVI, KATHERINE SCOVNER (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Acidosis;Acids;Affect;Arrhythmia;Award;base;Bicarbonates;Biometry;Blood Pressure;Bradyarrhythmias;Bradycardia;Cardiac;Cardiac Electrophysiologic Techniques;Cardiology;Cardiovascular system;catalyst;Cessation of life;clinical investigation;Clinical Investigator;clinically significant;Cohort Studies;Complement;Complication;Confusion;Cross-Over Trials;Data;Death Rate;Development;Dialysis procedure;Double-Blind Method;Education;Electrocardiogram;Electrolytes;End stage renal failure;experience;Follow-Up Studies;Foundations;Frequencies;Funding;Future;Goals;Heart Arrest;heart rhythm;Hemodiafiltration;Hemodialysis;hemodynamics;high risk;Holter Electrocardiography;Hospitals;Human;Hypotension;Implant;improved;innovation;Institution;Investigation;K-Series Research Career Programs;Kidney;Leadership;Life;Maintenance;Malignant - descriptor;Master of Science;Measures;Medical;Mentors;Mentorship;Modification;Monitor;Morbidity - disease rate;mortality;Multicenter Studies;Myocardial Stunning;Observational Study;Outpatients;patient population;Patients;Play;Positioning Attribute;prevent;programs;Public Health;Randomized;randomized trial;Reporting;Research;Research Design;Research Personnel;Resources;responsible research conduct;Risk;Role;Sample Size;Science;Serum;skill acquisition;sudden cardiac death;Sudden Death;symposium;Symptoms;Testing;Time;Training;United States;Ventricular;Ventricular Arrhythmia;Ventricular Premature Complexes;Ventricular Tachycardia;Woman

PROJECT_TITLE: Association of Dialysate Bicarbonate with Hemodynamic Instability and Arrhythmia

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Natural Products;Rare Diseases

ORG_CITY: AUSTIN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative: Polyketides are used more in human medicine than any other class of secondary metabolites, and comprise roughly 20% of top-selling small-molecule drugs. This project advances catalytic methods for the de novo chemical synthesis of polyketides based on hydrogen auto-transfer processes that enable direct stereo- and site-selective conversion of lower alcohols to higher alcohols. Polyketide natural products that possess anti-cancer and anti- bacterial properties are targeted.

PI_NAMEs: KRISCHE, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Polyketides via Redox-Triggered Alcohol C-H Functionalization

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Cerebral Palsy;Clinical Research;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Rehabilitation;Rehabilitation

ORG_CITY: TUCSON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Cerebral palsy is characterized by a progressive decline in mobility due to gait dysfunction caused by deficits in strength and coordination. This proposal investigates a novel wearable adaptive resistance therapy for improving neuromuscular control and walking outcomes in this patient population. Completion of this work will contribute to a better understanding of the factors necessary for successful rehabilitation of children with neuromuscular impairment.

PI_NAMEs: CONNER, BENJAMIN CHARLES (contact)

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: Acclimatization;Address;Adult;Advanced Development;Affect;Ankle;Brain;career;Cerebral Palsy;Child;Childhood;Data;Development;Devices;Educational Intervention;Educational Status;Environment;evidence base;Evidence based intervention;exoskeleton;exoskeleton device;Flexor;follow up assessment;follow-up;functional decline;functional independence;functional restoration;Future;Gait;Gait abnormality;Goals;H-Reflex;Impairment;improved;improved mobility;Individual;Intervention;Investigation;Knowledge;Lead;Maintenance;Measures;Metabolic;Mobility decline;Modality;Motor;motor learning;Movement;Movement Disorders;Muscle;muscle strength;Muscle Weakness;neuromuscular;neuromuscular rehabilitation;neuroregulation;Neurosciences;novel;novel therapeutics;Outcome;Paper;Participant;patient population;peer;Physical activity;physically handicapped;Physicians;Pilot Projects;Population;primary outcome;Protocols documentation;recruit;Reflex action;Rehabilitation therapy;Research;Research Proposals;Resistance;resistance exercise;response;Scheme;Scientist;Secondary to;Soleus Muscle;Specificity;Stimulus;stretch reflex;synergism;Technology;Testing;Time;tool;Training;Treatment Efficacy;Visit;Walking;wearable device;Work

PROJECT_TITLE: Investigation of the neuromuscular response and training effects of wearable adaptive resistance in children with cerebral palsy


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Infectious Diseases;Physical Injury - Accidents and Adverse Effects;Prevention;Wound Healing and Care

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Local application of antibiotics directly to the traumatic wound is a promising treatment for the prevention of infection after open tibia fractures, which are a significant source of disease burden globally, particularly in low- income countries. This pilot study aims to assess feasibility of a randomized controlled trial to measure the effect of locally applied gentamicin on risk of infection for open tibial fractures in Tanzania. If proven effective, local gentamicin would be a highly cost-effective strategy to reduce complications and disability from open tibial fractures that could impact care in both high- and low-income countries.

PI_NAMEs: SHEARER, DAVID WILLIAM (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Adult;Advocate;Aminoglycosides;Amputation;Antibiotics;aqueous;Award;Blood flow;bone;bone fracture repair;bone healing;burden of illness;Caring;Chronic;Clinical;Clinical Research;clinical trial enrollment;Clinical Trials;Clinical Trials Design;cohort;compare effectiveness;Complication;cost;cost effective;cost effectiveness;Cost Effectiveness Analysis;cost estimate;Cost Savings;cost-effectiveness ratio;Data;Data Analyses;Debridement;disability;Disease;Economic Burden;economic evaluation;economic outcome;Economics;Effectiveness;Enrollment;EuroQOL;Event;experience;Failure;Focal Infection;Fracture;fracture risk;Gentamicins;Genus staphylococcus;healing;Health;Hospital Referrals;Impairment;improved outcome;incremental cost-effectiveness;Infection;Infection prevention;infection risk;Injections;Injury;innovation;intervention cost;Intervention Studies;Intravenous;Leg;Literature;long bone;low income country;markov model;Masks;Measures;Medical Care Costs;Methodology;microcosting;Modeling;Morbidity - disease rate;multidisciplinary;North America;Observational Study;Open Fractures;open wound;Operative Surgical Procedures;Orthopedics;Osteomyelitis;Outcome;Participant;pathogen;Patients;Pilot Projects;pilot trial;Placebos;Population;Powder dose form;prevent;Prevention strategy;primary outcome;Principal Investigator;prophylactic;prospective;Quality of life;Quality-Adjusted Life Years;radiological imaging;Randomized;randomized placebo-controlled clinical trial;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Repeat Surgery;Research;Research Design;Risk Reduction;Rod;Saline;sample fixation;secondary analysis;secondary outcome;Site;skills;Skin;Source;Surgical wound;Survey Methodology;Tanzania;Target Populations;Techniques;tibia;Tibial Fractures;Time;Trauma;trauma centers;traumatic wound;treatment group;Vial device;wound;wound closure

PROJECT_TITLE: A Pilot Masked, Randomized Controlled Trial Evaluating Locally-applied Gentamicin versus Saline in Open Tibia Fractures (pGO-Tibia)

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Digestive Diseases;Nanotechnology;Orphan Drug;Pancreatic Cancer;Radiation Oncology;Rare Diseases;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE: The promise of nanoparticle (NP) anticancer drugs remain largely unfulfilled due to a low tumor delivery, in which only 5-10% of these agents in the plasma are actually distributed into solid tumors. Thus, there is a strong need to discover methods that can capitalize on the promise of NP anticancer drugs by significantly and safely enhancing tumor delivery, especially in pancreatic cancer (PaCa) that has major inherent barriers to tumor delivery that are associated with high resistance and low response. Our proposal will evaluate if induction minibeam radiation therapy (MRT), in contrast to conventional broad beam radiation therapy (BRT), increases tumor perfusion, and the tumor delivery and efficacy of NPs in PaCa tumor models, as the induction MRT + NP regimen would be an ideal fit for the pre-surgical neoadjuvant treatment of PaCa.

PI_NAMEs: CHANG, SHA X;LIBUTTI, STEVEN K.;ZAMBONI, WILLIAM C (contact)

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: Abraxane;Acute;Albumins;Antineoplastic Agents;barrier to care;Blood Vessels;Breast Cancer Model;cancer therapy;carcinogenesis;Characteristics;chemokine;chemotherapy;Clinical Trials;Collagen;comparative;density;Development;Disease;Doxorubicin;Drug Delivery Systems;Drug Kinetics;Excision;FDA approved;Fibrinogen;Formulation;Genetically Engineered Mouse;Grant;improved;Interdisciplinary Study;irinotecan;Liposomes;Macrophage;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;Measurement;Measures;Mediating;Methods;Modeling;multidisciplinary;nanoparticle;nanoparticle delivery;Neoadjuvant Therapy;Normal tissue morphology;novel;Operative Surgical Procedures;Paclitaxel;pancreatic cancer model;Patients;Perfusion;Permeability;Pharmaceutical Preparations;Pilot Projects;Plasma;Positron-Emission Tomography;preclinical study;Prior Therapy;programmed cell death ligand 1;Radiation;Radiation Dosage;Radiation therapy;Rattus;Regimen;Reporting;Resectable;Resistance;response;small molecule;Solid;Solid Neoplasm;Sterically Stabilized Liposome;systemic toxicity;Technology;Therapeutic;therapeutic nanoparticles;Toxic effect;Translating;tumor;tumor microenvironment;Tumor Tissue;uptake;Vascular Endothelial Growth Factors;Work

PROJECT_TITLE: Minibeam Radiation Therapy Enhanced Delivery of Nanoparticle Anticancer Agents to Pancreatic Cancer Tumors


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Biotechnology;Cardiovascular;Gene Therapy;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Cardiovascular diseases (CVD) are the leading cause of death in the US and worldwide, requiring new therapeutic development for CVD prevention and treatment. This project aims to develop genome editing therapeutic strategies to treat the hyperlipidemia-associated CVD.

PI_NAMEs: HAN, RENZHI  (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: Adenine;American;ANGPTL3 gene;Arterial Fatty Streak;Atherosclerosis;base editing;base editor;Benchmarking;Biochemical;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;Cardiovascular system;Cause of Death;Cells;Cessation of life;Cholesterol;clinical practice;Clustered Regularly Interspaced Short Palindromic Repeats;combat;Combined Modality Therapy;Communication;Complex;Consumption;Coronary Arteriosclerosis;coronary artery occlusion;Coronary heart disease;Coronary Occlusions;Dangerousness;deep sequencing;Dependovirus;design;Development;Dietary Fats;Disease;DNA;DNA Double Strand Break;DNA Sequence Alteration;Duchenne muscular dystrophy;Dyslipidemias;Dystrophin;empowerment;Environmental Risk Factor;Enzyme-Linked Immunosorbent Assay;Event;Genes;genetic approach;genetic variant;genome editing;genome wide association study;Genomic DNA;Guide RNA;Heart;heart disease risk;Heart Diseases;High Density Lipoproteins;High Fat Diet;Histologic;hypercholesterolemia;Hyperlipidemia;Hypertriglyceridemia;Immune response;improved;in vivo;Incidence;inherited cardiomyopathy;inhibitor;Knockout Mice;LDL Cholesterol Lipoproteins;Lesion;Light;lipid metabolism;Lipids;Liver;loss of function mutation;Low-Density Lipoproteins;Measurement;Mediating;Medicine;Molecular;mouse model;Mus;Mutation;Myocardial Infarction;Nature;new therapeutic target;Nonsense Mutation;novel;novel therapeutics;Organ;Patients;Pharmaceutical Preparations;Physiological;Plasma;Point Mutation;prevent;Publishing;Reagent;research and development;Residual state;restoration;Risk;Risk Factors;RNA;RNA Editing;Role;Running;Safety;Serology;Specificity;Stains;System;T-Lymphocyte;Technology;technology platform;Testing;Therapeutic;therapeutic development;Therapeutic Effect;therapeutic genome editing;transcriptome;transcriptome sequencing;transcriptomics;tumorigenic;United States;Viral Packaging

PROJECT_TITLE: Base editing of ASGR1 for cardiovascular disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: PROJECT NARRATIVE Alzheimer disease (AD), the leading cause of dementia, is defined by the buildup of amyloid plaques in the brain made of Aβ protein and neurofibrillary tangles made of tau protein, but many people have high levels of amyloid plaque and no symptoms of dementia; furthermore, clinical trials of medications that showed removal of plaques mostly have not improved dementia symptoms. This proposal tests whether different people have different molecular types of Aβ in their brains, what they might look like under powerful microscopes, and whether different people’s neurons are differently affected by the most toxic forms of Aβ. This work has the potential to improve the design of new drugs for AD, improve clinical trials for existing AD investigative drugs, and identify new targets for future AD drug development.

PI_NAMEs: STERN, ANDREW MICHAEL (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: abeta accumulation;abeta oligomer;Address;Aducanumab;Affect;age related;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Amyloid;Amyloid beta-Protein;Amyloid Fibrils;amyloid pathology;Antibodies;Autopsy;behavioral neurology;Binding;Biochemical;Biochemistry;Brain;brain tissue;Calcium;career development;Cellular biology;Characteristics;chelation;Chemistry;Clinical;Clinical Trials;Clinical Trials Design;Cognitive;cohort;Collaborations;Cryoelectron Microscopy;Data;Dementia;design;Development Plans;Disease;disease model;disease-causing mutation;Doctor of Philosophy;Drug Design;drug development;Egtazic Acid;Enzyme-Linked Immunosorbent Assay;Equipment;Excision;experience;experimental study;Exposure to;Failure;Funding;Future;Generations;Genetic;Genetic Heterogeneity;Genotype;Goals;Grant;Heterogeneity;Hospital Departments;Hospitals;Human;hyperphosphorylated tau;Image;Impaired cognition;improved;In Vitro;Individual Differences;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;innovation;Instruction;instructor;Kinetics;Knowledge;Laboratories;Lead;Lesion;live cell imaging;Mass Spectrum Analysis;Measures;meetings;Mentors;Mentorship;Metabolism;Microscope;Modeling;Molecular;Molecular Conformation;Molecular Weight;Monoclonal Antibodies;monomer;multi-electrode arrays;Nerve Degeneration;Neurites;Neurofibrillary Tangles;Neurology;neuron loss;Neurons;neuropathology;neuroprotection;neurotoxic;neurotoxicity;novel;novel therapeutics;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Peptides;Persons;Pharmaceutical Preparations;Phenotype;Phosphorylation;Post-Translational Protein Processing;Predisposition;preference;Property;Protein Chemistry;Protein Conformation;Proteins;Publishing;reduce symptoms;Research;research and development;Research Personnel;resilience;Resolution;response;Senile Plaques;skills;Specificity;stem cells;structural biology;Structure;success;symposium;Symptoms;Synapses;tau aggregation;tau mutation;tau Proteins;tau-1;Testing;theories;therapeutic development;Time;Tissues;tool;Toxic effect;Training;Ultracentrifugation;Woman;Work;Writing;β-amyloid burden

PROJECT_TITLE: Heterogeneity in Toxicity of Oligomeric Amyloid Beta and Neuronal Resilience in Alzheimer Disease


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Hematology

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The goal of this Program is to attract and to train exceptional postdoctoral fellows for careers in academic adult hematology. Improved understanding of the underpinnings of stem cell biology, hemoglobinopathies, thrombotic microangiopathies, bone marrow failure states, and myeloproliferative diseases will aid in translating laboratory findings into novel clinical therapies.

PI_NAMEs: BRODSKY, ROBERT A (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Hematology;Training Programs

PROJECT_TITLE: Training Program in Hematology

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


NIH_SPENDING_CATS: Assistive Technology;Autoimmune Disease;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Pediatric;Prevention

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: NARRATIVE Adolescence is commonly a time of sub-optimal control of Type 1 diabetes (T1D), with a spike in mean HbA1c levels during the age range between 11-15 years; this deterioration in control is in part due to a rise in insulin resistance and the presence of key psychosocial issues, including family dynamics, peer influence and diabetes distress. We propose a comprehensive two-year study of pubertal children, using state-of-the-art techniques to follow these physiologic processes and explore psychosocial factors, while testing a promising intervention, the Control-IQ version of the artificial pancreas (AP). We hypothesize that the AP will respond to the underlying challenges and blunt the rise in HbA1c, thereby reducing long-term risks of sub-optimal T1D control among adolescents.

PI_NAMEs: BRETON, MARC D;DEBOER, MARK DANIEL (contact)

PROGRAM_OFFICER_NAME: THORNTON, PAMELA L

PROJECT_TERMS: Address;Adipose tissue;Adolescence;Adolescent;adolescent health;Age;Artificial Pancreas;Attenuated;Blood Glucose;blood glucose regulation;Child;clinical care;Complex;Conflict (Psychology);Continuous Glucose Monitor;Control Groups;Data;Deterioration;Development;diabetes control;diabetes distress;diabetes management;Diabetes Mellitus;Distress;Dose;Environment;Evaluation;Evolution;Family;Family dynamics;Family Process;follow-up;Glucose;glycemic control;Glycosylated hemoglobin A;Goals;Group Affiliation;Hyperglycemia;Hypoglycemia;improved;Injections;innovation;Insulin;Insulin Infusion Systems;Insulin Resistance;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;Intervention;Label;Link;Liver;Mental Depression;Modernization;Muscle;Natural History;novel;Outcome;Participant;pediatric patients;Peer Group;peer influence;pharmacologic;Physiological;Physiological Processes;Physiology;Process;provider factors;psychologic;Psychology;psychosocial;Psychosocial Factor;Psychosocial Influences;psychosocial stressors;Puberty;Quality of life;Randomized;Recommendation;response;Risk;stable isotope;System;Techniques;Technology;Testing;Time;Tracer;treatment as usual;trend;Universities;uptake;Virginia;Youth

PROJECT_TITLE: Artificial Pancreas - Adolescent Physiology and Psychology Longitudinal Evaluation (A.P. APPLE)

STUDY_SECTION: CIDO

STUDY_SECTION_NAME: Clinical and Integrative Diabetes and Obesity Study Section[CIDO]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: Jupiter

ORG_NAME: MAX PLANCK FLORIDA CORPORATION

ORG_STATE: FL

PHR: Project Narrative Episodic memory is a unique type of memory that enables us to mentally travel back in time to re-experience specific episodes that occurred in our lives. During memory encoding, continuous experience is segmented into episodes each encoding a sequence of temporally organized events; however, little is known about the neural circuits that perform computations to segment experience and encode sequential events. Revealing how the hippocampal circuits perform these computations will provide key insights into understanding episodic memory both in health and in pathological conditions such as dementia and Alzheimer’s disease where patients’ life quality is profoundly disrupted due to impaired episodic memory.

PI_NAMEs: WANG, YINGXUE  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Affect;alertness;Alzheimer's Disease;Alzheimer's disease patient;Animals;Area;Attention;Back;Behavior;Behavioral;Behavioral Paradigm;Behavioral trial;Brain;Brain region;cell type;Cells;cholinergic;cholinergic neuron;Cholinergic Receptors;Cues;Dementia;design;Disease;Electrophysiology (science);Elements;Environment;Episodic memory;episodic memory impairment;Event;experience;Generations;Genetic;Goals;Health;Hippocampal Formation;hippocampal pyramidal neuron;Hippocampus;Image;Impairment;in vivo;Individual;insight;interdisciplinary approach;Interneurons;Location;Locomotion;Measurement;Measures;Medial;Mediating;Memory;memory encoding;neural circuit;Neurons;neuroregulation;novel;optogenetics;Outcome;Parvalbumins;Pathologic;Patients;Pattern;Performance;Play;Population;Psyche structure;Quality of life;Role;Running;Sensory;sensory input;Signal Transduction;Site;Somatostatin;Stream;Synapses;System;Testing;Time;Travel;treadmill;two-photon;Visit

PROJECT_TITLE: Generation mechanisms of memory-related internal sequences in the hoppocampal CA1 region

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Infectious Diseases;Urologic Diseases

ORG_CITY: Richmond

ORG_NAME: WYNNVISION, LLC

PHR: PD/PI Kennard Brunson Abstract Toward urinary catheterization with long-term resistance to bacterial colonization Problem: Catheter Associated Urinary Tract Infections (CAUTI) are common infections in hospitals and health care facilities especially for the disabled and the elderly and infirm with longer catheter indwelling times. To fight CAUTIs, WynnVision LLC has developed “WynnGard-1” silicone, which introduces a robust surface component that reduces bacterial colonization. With no depletion of a leached agent, patented WynnGard-1 silicone has the potential for long term antimicrobial effectiveness. R&D under this Phase IIB proposal will answer FDA concerns and de- risk the technology to make low-cost WynnGard-1 silicone attractive for commercialization.

PI_NAMEs: ZOLOTARSKAYA, OLGA  (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: Accidents;Address;Amines;Anatomy;Animals;Antibiotic Resistance;Antibiotics;antimicrobial;Bacteria;Bacterial Attachment Site;bacterial resistance;Belief;Biocide;biomaterial compatibility;Boston;catheter associated UTI;Catheterization;Catheters;cell growth;Characteristics;Charge;Chemicals;Classification;Clinical;commercialization;cost;Coupled;Critical Care;Data;design;Device Safety;Devices;disabled;Drug Combinations;Ear;Economics;Effectiveness;Elderly;Escherichia coli;Evaluation;experimental study;Female;fighting;flasks;Gram-Negative Bacteria;Growth;Health;Health care facility;Heavy Metals;high risk;hospice environment;hospital care;Hospital Costs;Hospitalization;Hospitals;Human;Hydrogels;hydrophilicity;Immersion;In Vitro;in vivo;Indwelling Catheter;Infection;innovation;insight;interest;Knowledge;Legal patent;Licensing;manufacture;Manufacturer;Marketing;Medical;Medical Device;meetings;men;Microbial Biofilms;Microscopy;Modification;Morbidity - disease rate;Multi-Drug Resistance;new technology;North America;Nose;novel;novel strategies;Nursing Homes;Oryctolagus cuniculus;Paralysed;pathogen;Pathway interactions;Patients;Performance;Pharmaceutical Preparations;Pharyngeal structure;Phase;Pilot Projects;Population;Positioning Attribute;Predisposition;Prevalence;Price;Procedures;Process;Progress Reports;Protocols documentation;Publishing;Radiologic Health;Rattus;Research;Research Activity;research and development;Resistance;response;Risk;Safety;Silicones;Silver;Surface;systemic toxicity;Technology;Testing;Toxicity Tests;urinary;Urinary Catheterization;Urinary tract infection;Urine;Weight;Woman;women subjects;Work


ORG_CITY: LEXINGTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE  Colorectal cancer mortality is predominantly due to the development of disseminated disease and resistant to conventional chemotherapy. Our study focuses on developing a mechanistic understanding of PHLPP- mediated regulation of cellular stress signaling to circumvent chemoresistance. Results from our studies will help identify new treatment options and better predict the effectiveness of chemotherapy agents.

PI_NAMEs: GAO, TIANYAN  (contact)

PROGRAM_OFFICER_NAME: CERO, CHERYL

PROJECT_TERMS: Automobile Driving;Autophagocytosis;biological adaptation to stress;cancer cell;Cancer Etiology;cancer initiation;Cancer Patient;cancer survival;cancer type;Cell Death Induction;cell growth regulation;Cell Migration Inhibition function;Cell Proliferation;Cell Survival;Cells;Cellular Stress;Cessation of life;Chemoresistance;chemotherapy;Collaborations;Colon Carcinoma;colon tumorigenesis;Colorectal Cancer;coping;coping mechanism;Development;Disease;Down-Regulation;Effectiveness;EIF-2alpha;endoplasmic reticulum stress;Ensure;Epithelial Cells;Equilibrium;Event;Funding;Grant;HK2 gene;improved;in vivo;Inflammation;Inflammatory;insight;Integrins;Intestines;Knockout Mice;Knowledge;leucine-rich repeat protein;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Metabolic;Metabolism;Mitochondria;mitochondrial autophagy;Molecular;mortality;mouse model;multicatalytic endopeptidase complex;novel;Oncogenic;Organism;Pathway interactions;PH Domain;Pharmaceutical Preparations;Phosphoric Monoester Hydrolases;Phosphorylation;Physiological;Play;Protein Dephosphorylation;protein expression;Protein Family;Protein Kinase;Protein phosphatase;Proto-Oncogene Proteins c-akt;Regulation;Resistance;response;Role;sensor;Signal Pathway;Signal Transduction;Stress;success;Supporting Cell;Testing;tumor initiation;tumor metabolism;tumor progression;Tumor Suppressor Proteins;tumorigenesis;United States

PROJECT_TITLE: The Role of PHLPP in Colon Cancer

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Dietary Supplements;Genetics;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Rehabilitation

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE Peripheral nerve injury is a serious clinical problem that affects approximately 360,000 people every year in the United States alone.This proposal aims at developing novel epigenetically stimulating, biodegradable, and pho- toacoustic nerve guidance conduits (NGCs) for the repair of critical-sized peripheral nerve (PN) defects

PI_NAMEs: YAN, SU  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: absorption;Affect;Anatomy;Ankle;Athletic Injuries;Autologous Transplantation;Biochemical;Biocompatible Materials;biodegradable polymer;bioimaging;Biomechanics;Blood Vessels;Bone Screws;Cell Separation;Cells;Citrates;Clinical;crosslink;Cues;Data;Defect;Deoxygenated Sickle Hemoglobin;design;Development;Diagnosis;Diameter;Disadvantaged;Dose;Elasticity;elastomeric;Elastomers;Elbow;Epigenetic Process;Evolution;fabrication;FDA approved;Fiber;Folic Acid;foot;Genes;Goals;Half-Life;implantation;improved;In Situ;in situ imaging;in vivo;in vivo evaluation;Injury;injury and repair;innovation;interest;Knee;Light;Maps;Marketing;Medical Device;Methodology;migration;Modality;Monitor;Morbidity - disease rate;Morphogenesis;Natural regeneration;Nerve;nerve gap;Nerve Regeneration;Neuroma;neuron regeneration;Neuronal Differentiation;Neurons;novel;Numbness;Operative Surgical Procedures;Orthopedics;Outcome;Peripheral;Peripheral nerve injury;peripheral nerve regeneration;Peripheral Nerves;Persons;photoacoustic imaging;Polyesters;Polymers;Porosity;Postoperative Period;Process;Proliferating;Rattus;Recovery of Function;regenerative;Regenerative capacity;Regulation;repaired;Research;Resistance;Role;scaffold;sciatic nerve;sciatic nerve injury;Series;Shoulder;Site;Speed;Spinal Ganglia;Structure;success;Surgical sutures;Time;tissue oxygenation;Tissues;Ultrasonography;United States;Urethane;Vitamins;Wrist

PROJECT_TITLE: Photoacoustic and epigenetic nerve scaffold for nerve regeneration

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Digestive Diseases;Liver Disease

PHR: PROJECT NARRATIVE This research training program addresses a critical need by preparing young physicians for visionary and committed research careers in basic, as well as translational and clinical sciences that improve digestive health, including health care delivery and equity. This program will provide rigorous and personalized training that enables emerging researchers to accelerate the translation of discoveries into new approaches to the diagnosis and management of gastrointestinal and hepatic diseases.

PI_NAMEs: COHEN, DAVID E. (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Gastrointestinal Diseases;Liver diseases;Research Training

PROJECT_TITLE: Research Training in Gastrointestinal and Hepatic Diseases


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE Pancreatic cancer (PDAC) continues to have an extremely poor prognosis, with the 5-year survival rate of those diagnosed less than 5 percent. A broader understanding of PDAC initiation and the earliest events of disease progression is needed for the development of better early detection methods and new therapies. Our preliminary results suggest specific cells of the adult pancreas may contain a cell of origin for PDAC; the proposed research will utilize a genetically engineered mouse model to interrogate the capacity of these cells to initiate precancerous lesions and cancer, helping us to gain new insights into human disease.

PI_NAMEs: MCANDREWS, KYLE  (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Acinar Cell;Address;Adult;adult stem cell;Amphiregulin;Animals;Behavior;Biology;blind;cancer initiation;cancer stem cell;cancer subtypes;Carcinoma;Cell Lineage;cell motility;cell type;Cells;Color;Colorectal Cancer;CRISPR/Cas technology;Cystic Neoplasm;Data;detection method;Development;Diagnosis;Disease;Disease Progression;driver mutation;Ductal Epithelial Cell;Ductal Epithelium;Early Diagnosis;Enterobacteria phage P1 Cre recombinase;Epidermal Growth Factor Receptor;epithelial stem cell;Event;Evolution;Exhibits;experimental study;Family;Future;Gastrointestinal tract structure;Gene Expression;Gene set enrichment analysis;Genetically Engineered Mouse;Gland;Histology;Human;human disease;implantation;in vivo;Inflammation;insight;intestinal crypt;intestinal epithelium;Knock-out;Lesion;Ligands;Main pancreatic duct;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;Methods;Micro Array Data;migration;Modeling;Mucinous;Mucinous Neoplasm;Mus;Mutation;Natural regeneration;novel;novel therapeutics;Oncogene Activation;Oncogenes;Oncogenic;Organoids;Pancreas;pancreatic cancer model;Pancreatic duct;Pancreatic Intraepithelial Neoplasia;Pancreatitis;Papillary;Pathogenesis;Pathway interactions;Phenotype;Physiologic pulse;pluripotency;Population;Predisposition;premalignant;Prognosis;Prognostic Factor;promoter;Property;repaired;Reporter;Research;response;Role;single cell analysis;Specific qualifier value;stem;stem cell niche;stem cell population;stem cells;stemness;Survival Analysis;Survival Rate;Testing;TP53 gene;transcriptome sequencing;Transgenic Mice;trefoil factor;tumor progression;Tumorigenicity

PROJECT_TITLE: Oncogenic insults within the pancreatic ductal glands produce pre-malignant lesions and PDAC


NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative: Acute kidney injury is one of the most common kidney pathologies and a common cause of chronic kidney disease leading to dramatically reduced life expectancy. To date there are no clinically proven therapies for treating acute kidney injury. This application identifies novel mechanisms that protects the kidney against acute kidney injury and has significant therapeutic potential to treat the ever-growing number of acute kidney injury patients.

PI_NAMEs: SIMS-LUCAS, SUNDER  (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;acyl-CoA oxidase;Affect;Age;Animal Model;Apoptosis;Automobile Driving;Cells;Cellular Metabolic Process;Chemicals;Chronic;Chronic Kidney Failure;Cisplatin;Clinical;comparison control;Coupled;Data;Data Correlations;disease model;Dose;effective therapy;enzyme activity;Enzymes;Epithelial Cells;Exhibits;fatty acid oxidation;Functional disorder;genetic manipulation;Goals;Histologic;Hospitalization;Human;Human Cell Line;In Vitro;in vivo;in vivo Model;Infusion procedures;Injury;Injury to Kidney;Ischemia;Kidney;knock-down;Knock-out;Knockout Mice;Life Expectancy;Link;Liver;Long-Chain-Acyl-CoA Dehydrogenase;Lysine;Measures;Metabolic;metabolomics;Mitochondria;mitochondrial metabolism;Modeling;Morbidity - disease rate;mortality;Mouse Cell Line;Mus;nephrotoxicity;novel;novel therapeutics;Organelles;oxidative damage;Oxidative Stress;Pathogenesis;Pathology;Pathway interactions;Patients;Peptides;peroxisome;pharmacologic;prevent;Proteins;Proteomics;Reactive Oxygen Species;Renal function;renal ischemia;repaired;Reperfusion Injury;Reperfusion Therapy;Repression;Resistance;response;Risk;Role;Sirtuins;Site;Small Interfering RNA;Testing;Therapeutic;therapeutic target;Tissues;Tubular formation;Up-Regulation;Western Blotting

PROJECT_TITLE: The role of Sirtuin 5 in acute kidney injury

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: KANSAS CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI KANSAS CITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE African Americans (AAs) have rates of diabetes mellitus (DM) twice that of Whites and are disproportionately affected by leading risk factors for DM – obesity and low-income. A critical strategy in the battle against DM is the Diabetes Prevention Program (DPP), an evidence-based intervention that significantly delays or prevents Type 2 diabetes through the promotion of diet change, exercise and modest weight loss. However, weight loss from the DPP among AAs is about half that of White participants, and suboptimal AA attendance is a critical contributor. We propose to conduct a study that will address social determinants (SD) that challenge DPP attendance with underserved African Americans from a safety net hospital. We will examine DPP attendance and weight loss with participants randomized to 3 groups: standard DPP, a culturally-tailored DPP to address acceptability, and a culturally-tailored DPP enhanced to address socioeconomic-related barriers to DPP participation. This novel study is the first to tailor the DPP to address SD cultural and socioeconomic barriers that limit DPP attendance and reduce its effectiveness on outcomes. The proposed multidimensional, SD tailored DPP has great potential to be a feasible and scalable model to reduce DM risks among urban, African Americans and ultimately reduce DM disparities.

PI_NAMEs: BERKLEY-PATTON, JANNETTE YVONNE (contact)

PROGRAM_OFFICER_NAME: ARTIS DICKERSON, SHAVON

PROJECT_TERMS: Address;Affect;African American population;Amputation;arm;Behavior;Black church;Blood Pressure;Body Weight decreased;Cardiovascular Diseases;Caring;Clinical;Communities;community engaged approach;Community Health Aides;community setting;comorbidity;cost;Diabetes Mellitus;diabetes prevention program;Diet;Dimensions;Disparity;Dose;Economics;Effectiveness;Evidence based intervention;Exercise;experience;Face;financial incentive;flexibility;follow-up;Food;Glycosylated hemoglobin A;Health;health disparity;Health education;Health Food;Health Resources;Hospitals;Hybrids;Improve Access;improved;improved outcome;Intervention;intervention program;Language;lens;lifestyle intervention;Literature;Low income;Mediator;Modeling;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Office Visits;Outcome;Overweight;Participant;Patients;Persons;Physical activity;Physicians;Pilot Projects;Population;prevent;primary outcome;process evaluation;Randomized;randomized trial;Randomized, Controlled Trials;Religiosity;Reporting;Resources;Risk;Risk Factors;safety net;secondary outcome;social culture;social determinants;social health determinants;Social support;sociocultural determinant;socioeconomics;success;Testing;Text;theories;Time;translational study;Translations;Visit;weight loss program;Work

PROJECT_TITLE: Addressing Social Determinants of Health to Improve Diabetes Prevention Program Outcomes Among Underserved African Americans

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: TORRANCE

ORG_NAME: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER

PHR: Project Narrative: We propose to establish a “Center for Male Reproductive Epigenomics” aiming to study both the impact of life style or environmental (diet/activity) factors on the integrity of the sperm epigenome, and the key molecular mechanisms underlying sperm-mediated epigenetic inheritance of disease.

PI_NAMEs: YAN, WEI  (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Address;Adopted;cell type;combinatorial;Development;Diet;diet and exercise;Disease;disease phenotype;DNA Methylation;Environment;Epigenetic Process;epigenome;epigenomics;Exercise;Fathers;Fatty acid glycerol esters;Future;Gene Expression;Gene Expression Profile;Generations;Germ Cells;Germ Lines;good diet;Health;healthy lifestyle;High Fat Diet;histone modification;Human;Incidence;Inherited;innovation;intergenerational;Investigation;Lead;Life Style;male;man;Mediating;men;Metabolic Diseases;Molecular;Mus;National Institute of Child Health and Human Development;Obesity;offspring;Phenotype;physical inactivity;reproductive;Research;response;Somatic Cell;Son;sperm cell;Testing;trait;transgenerational epigenetic inheritance;transmission process;unhealthy lifestyle;Untranslated RNA


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Genetics;Hearing Loss;Neurosciences

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Rapid and reliable signaling from the cochlea to the brain depends on close interactions between neurons and glia, specialized cells that keep the neurons healthy and directly influence their function. By studying how these critical functional units form during development, we will identify new ways to repair the damaged cochlea, with additional relevance to glioblastoma, inherited hearing loss, and hearing loss that is acquired with noise or age.

PI_NAMEs: GOODRICH, LISA  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Ablation;Acute;Affect;Age;Auditory;Axon;Behavior;Brain;cell type;Cells;Central Nervous System;Cochlea;cochlear development;conditional knockout;Connective Tissue;Cues;Cytoskeleton;Data;Detection;Development;Diphtheria Toxin;Disease;Embryo;Embryonic Development;Endowment;Event;experience;experimental study;Family;follow-up;Freezing;GATA2 deficiency;GATA2 transcription factor;GATA3 gene;Gene Expression;Genes;Genetic;genetic approach;glial cell development;Glial Differentiation;Glioblastoma;Goals;Hair Cells;Hearing;hearing impairment;hereditary hearing loss;Human;Image;In Situ Hybridization;in vivo;Individual;insight;Ions;Knockout Mice;Knowledge;Label;Labyrinth;Learning;Mediating;migration;Molecular;Molecular Genetics;Morphology;Mouse Strains;Movement;Mus;mutant;Mutant Strains Mice;Mutate;Mutation;myelination;Natural regeneration;nerve supply;Neural Crest;Neural Crest Cell;Neurites;Neuroglia;neuron development;neuron loss;neuronal cell body;neuronal survival;Neurons;Noise;Organ of Corti;otoconia;Pattern;Peripheral;Peripheral Nervous System;permissiveness;Phenotype;Play;Pluripotent Stem Cells;Population;prevent;Process;progenitor;Prognosis;programs;progressive hearing loss;Property;Publishing;Radial;repaired;Reporting;Role;Schwann Cells;Sensorineural Hearing Loss;Shapes;Signal Transduction;single-cell RNA sequencing;somatosensory;sound;Source;spiral ganglion;stem cell population;stemness;Supporting Cell;Syndrome;System;Testing;time use;tissue fixing;Toxin;transcription factor;transmission process;Viral;Visualization

PROJECT_TITLE: Neuron-Glia Interactions in the Cochlea

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


PHR: Project Narrative  The administrative core (Core A) will provide administrative supports to all research  projects and core labs in the Center for Male Reproductive Epigenomics, a premier  research program with a thematic focus on studying both the impact of life style or  environmental (diet/activity) factors on the integrity of the sperm epigenome, and the key  molecular mechanisms underlying sperm-mediated epigenetic inheritance of disease.

PROJECT_TERMS: Advisory Committees;Budgets;Calendar;Communication;Communities;Community Health Education;Community Outreach;Core Facility;data sharing;Deposition;Diet;Disease;Disputes;Educational workshop;Ensure;Epigenetic Process;epigenome;epigenomics;Event;Faculty;financial conflict of interest;Health;Institution;Life Style;male;Mediating;meetings;Molecular;news;organizational structure;Participant;Performance;Postdoctoral Fellow;programs;Public Relations;Publications;Recruitment Activity;reproductive;Research;Research Project Grants;Schedule;Source;sperm cell;Student recruitment;success;Travel;web site

PROJECT_TITLE: Administrative Core A


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Genetics;Human Genome;Nutrition;Obesity;Physical Activity;Prevention

PI_NAMEs: SWERDLOFF, RONALD SHERWIN (contact)

PROJECT_TERMS: Adult;Animals;cardiovascular disorder risk;Cells;Clinical Trials;Complex;Conceptions;Coupled;Cross-Sectional Studies;design;Development;Diabetes Mellitus;Diet;diet and exercise;Diet Modification;dietary;Disease Outcome;DNA Methylation;Educational Intervention;Environment;Environmental Exposure;Environmental Risk Factor;Epidemic;Epigenetic Process;epigenetic regulation;epigenome;epigenomics;Exercise;exercise training;experience;Fatty acid glycerol esters;Gene Expression;Gene Expression Regulation;Genetic;Genetic Programming;Genome;genome wide association study;Germ Cells;Goals;Health;Heritability;High Fat Diet;High Prevalence;Hispanic;histone modification;Human;human study;Hyperlipidemia;in utero;intergenerational;Intervention;late life;Life;Life Style;lifestyle intervention;Link;male;men;Metabolic;Metabolic Diseases;Metabolic syndrome;Modification;Molecular;Mus;next generation;Non-Insulin-Dependent Diabetes Mellitus;Nutritional;Obesity;obesity development;offspring;Outcome;Overweight;Pathogenesis;Pattern;Phenotype;physical inactivity;Population;Pre-Clinical Model;Prevalence;prevent;Randomized;recruit;Reporting;reproductive;Research Design;Research Personnel;resistance exercise;response;Risk;Single Nucleotide Polymorphism;sperm cell;Thinness;Translating;Translations;transmission process;Unhealthy Diet;unhealthy lifestyle;United States;Untranslated RNA;young man;young woman

PROJECT_TITLE: Diet and Exercise Modulate the Sperm Epigenome in Men


NIH_SPENDING_CATS: Genetics

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Narrative The androgen receptor (AR) is a hormone-binding protein that promotes prostate cancer development. One form continues to do so even after patients have been treated to remove the hormone. This project will determine the structural basis for these cancer-causing actions of this protein and pave the way for developing new and more effective treatments, by determining the structures of the complexes it forms with other proteins to increase expression of disease-causing genes.

PI_NAMEs: WANG, ZHAO  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: 3-Dimensional;Address;Affect;Androgen Receptor;androgen sensitive;antagonist;Binding;Biology;C-terminal;Cells;Complex;Computer Analysis;computerized data processing;Cryoelectron Microscopy;Data Collection;design;Development;Diabetes Mellitus;dimer;Dimerization;Disease;DNA;DNA Binding;DNA Structure;Drug resistance;Drug Targeting;effective therapy;EP300 gene;Estrogen Receptors;experimental study;Family;Foundations;Future;Gene Expression;Genes;Genetic Transcription;Goals;Heterogeneity;Hormonal;hormone binding protein;hormone deficiency;Hormones;Hypogonadism;image processing;Imaging Techniques;improved;innovation;insight;Knowledge;large scale data;Length;Ligand Binding Domain;Ligands;lipophilicity;Location;male;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;member;Molecular;Molecular Conformation;Monoclonal Antibodies;multidisciplinary;Mutagenesis;Mutation;N-terminal;nanometer resolution;Nuclear Hormone Receptors;Nuclear Receptors;particle;Pathway interactions;Patients;Pattern;Phenotype;Play;Productivity;promoter;protein protein interaction;Proteins;Receptor Activation;Recombinants;recruit;Regulation;Research Personnel;Resistance;Resolution;Response Elements;RNA Splicing;Site;small molecule inhibitor;Structure;System;targeted treatment;Techniques;Testing;therapeutic target;Transactivation;transcription factor;Transcription Process;Transcriptional Activation;Transcriptional Regulation;Variant;Visualization;Work

PROJECT_TITLE: Molecular mechanism of Androgen Receptor mediated transcription

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Mental health problems are responsible for a significant public health and socio-economic burden in the US. A shortage of research psychiatrists threatens future advances in the prevention and optimal treatment of mental illness. This application renews support for a psychiatry research residency track that nurtures the early career advancement of a diverse group of research psychiatrists, and provides them with the expertise needed to most effectively advance our understanding of the causation of mental health problems and the development of novel therapeutic strategies.

PI_NAMEs: SWERDLOW, NEAL R (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: ABCB1 gene;Acceleration;Address;Admission activity;Award;Benchmarking;Bioethics;Caliber;career;career development;Career Mobility;clinical care;Creativeness;Data Analyses;Dedications;design;Development;Doctor of Philosophy;Economic Burden;Education Projects;education research;Educational Curriculum;Educational process of instructing;Etiology;Evaluation;Faculty;Fellowship;Fellowship Program;Financial Support;Fostering;Funding;Future;Goals;Grant;health economics;improved;innovation;Institute of Medicine (U.S.);Investments;K-Series Research Career Programs;Laboratories;Learning;literacy;Manuscripts;Medical;medical schools;Medical Students;mental development;Mental disorders;Mental Health;Mentors;Mentorship;Minority Recruitment;minority trainee;Mission;National Institute of Mental Health;novel;novel therapeutic intervention;optimal treatments;Paper;Physicians;Positioning Attribute;posters;Preparation;Prevention;Privatization;Procedures;Process;programs;Psychiatrist;Psychiatry;Public Health;Publishing;Recommendation;recruit;Reporting;Research;Research Activity;research and development;Research Design;Research Personnel;Research Project Grants;Residencies;response;responsible research conduct;Rotation;Schools;Scientist;skills;socioeconomics;Solid;Strategic Planning;success;summer research;Supervision;Time;Training;Translational Research;Travel;treatment and outcome;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Writing

PROJECT_TITLE: Psychiatry Research Residency Training Track


PHR: Project Narrative  This study aims to uncover the potential hidden pathways for epigenetic information to flow from  somatic cells to male germ cells and sperm and thus, become heritable. Data to be obtained will fill  the knowledge gap in our understanding of the molecular mechanism underlying the  intergenerational epigenetic inheritance of paternally acquired traits in general.

PROJECT_TERMS: Adipocytes;Adult;Cell Transplantation;Data;dietary;disease phenotype;Embryo;embryo cell;Encapsulated;Epididymis;epigenetic memory;Epigenetic Process;epigenome;epigenomics;Epithelial Cells;experimental study;extracellular vesicles;Fathers;Generations;Genetic;Genome;Germ Lines;Glucose Intolerance;Glucose tolerance test;Hepatocyte;Heritability;High Fat Diet;Inherited;Injections;Insulin Resistance;intergenerational;Islet Cell;Islets of Langerhans;Knowledge;Lead;Liquid substance;male;Metabolic Diseases;MicroRNAs;Molecular;mouse model;Mus;neuronal cell body;Obesity;offspring;paracrine;Pathway interactions;Phenotype;Production;Regulation;Reproducibility;reproductive;reproductive tract;RNA;Seminiferous tubule structure;Series;sertoli cell;Shapes;Somatic Cell;sperm cell;Spermatocytes;Spermatogenesis;Spermatogenic Cell;Structure of efferent ductule of testis;Test Result;Testing;Testis;trait;transmission process

PROJECT_TITLE: Mechanism Underlying the Transduction of Epimutations from the Soma to the Male Germline


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative This study examines whether and how expanded access to affordable housing through rental assistance programs can improve type 2 diabetes self-management and control, ultimately reducing existing socioeconomic and racial disparities in diabetes outcomes. The study will examine the effect of rental assistance on diabetes self-management and control using nationally representative survey data, and by prospectively observing transitions from waitlists to rent-assisted housing through a longitudinal mixed- methods cohort study.

PI_NAMEs: KEENE, DANYA  (contact)

PROJECT_TERMS: Address;Adult;Adverse effects;Affect;Behavior;Behavior Control;Behavior Therapy;Behavioral;Biological;Blood Pressure;Body mass index;Caring;Chronic;Chronic Disease;Clinical;cohort;Cohort Studies;Complex;Complications of Diabetes Mellitus;cost;Cross-Sectional Studies;Data;Data Collection;Data Linkages;diabetes control;diabetes management;Diabetes Mellitus;diabetes self-management;Disease Management;Disease Outcome;Disparity;Eligibility Determination;experience;Face;Foundations;Gender;Glycosylated hemoglobin A;Goals;Health;Health behavior;health data;Health Surveys;Household;Housing;improved;Income;Individual;innovation;insight;Intervention;Interview;Lived experience;Longitudinal cohort;Longitudinal cohort study;Low income;Mediating;Methods;Modeling;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Outcome;Participant;Patients;Persons;Population;population health;Prevalence;prevent;Process;programs;prospective;Race;racial disparity;racial minority;racial minority population;Records;recruit;Research;Resources;Risk;Self Management;Shapes;Social Conditions;social determinants;socioeconomic disparity;Source;Stress;supported housing;Surveys;therapy design;Time;U.S. Department of Housing and Urban Development;voucher;Wages;Wait Time;Waiting Lists

PROJECT_TITLE: The effects of affordable housing access on type 2 diabetes self-management and control

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Genetics;Human Genome;Nutrition;Physical Activity;Prevention

PI_NAMEs: MCCARREY, JOHN R (contact)

PROJECT_TERMS: 3-Dimensional;Adult;Adult Children;Biological Assay;Cell Lineage;cell type;Cells;Characteristics;Chemical Exposure;Chromatin;Consumption;Data;Defect;design;Development;Diagnosis;Diet;diet and exercise;Disease;disease phenotype;DNA Methylation;Embryo;Enhancers;Environmental Exposure;Epigenetic Process;epigenome;epigenomics;Etiology;Event;Exercise;Experimental Designs;experimental study;Exposure to;Fetus;Future;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic;Germ Cells;Germ Lines;good diet;Heterogeneity;Hi-C;High Fat Diet;histone modification;Homo;Human;Incidence;Inherited;intergenerational;Life Style;male;Maps;Mediating;men;Molecular;mouse model;Nature;neuronal cell body;non-genetic;novel;offspring;Organ;Pathway interactions;Pattern;Prevalence;prevent;Productivity;promoter;pup;reproductive;Research;Role;Sampling;Series;single cell ATAC-seq;single-cell RNA sequencing;Smoking;Somatic Cell;Specificity;sperm cell;Spermatogenic Cell;Structure;Testing;Tissues;trait;transgenerational epigenetic inheritance;transmission process;Unhealthy Diet;Untranslated RNA

PROJECT_TITLE: Germline-mediated Transgenerational Epigenetic Inheritance of Paternal Epimutations Induced by a High Fat Diet


ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Advancing our understanding of gastrointestinal and liver diseases, a major public health problem in the United States, requires outstanding, cross-disciplinary training to promote paradigm-shifting advances that improve patient care. We propose to establish a multidisciplinary postdoctoral research training program in investigative Gastroenterology and Hepatology to foster the next generation of independent investigators through customized educational and research programs that empower trainees to attack unmet needs in gastrointestinal and liver diseases.

PI_NAMEs: FRIEDMAN, SCOTT L. (contact);MEHANDRU, SAURABH

PROJECT_TITLE: Training Program in Investigative Gastroenterology and Hepatology


NIH_SPENDING_CATS: Digestive Diseases;Nutrition;Pediatric

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE This Program is directly relevant to child health and development in training the next generation of scientists who will generate the advances essential for improving the quality of life and survival rates of children and adolescents with gastrointestinal, liver and nutrition-related disorders. Further, this training program represents an investment in the future of public health in general, as the multidisciplinary, intensive and innovative training provided by this Program will educate the leaders, teachers, and professional role models who will determine the direction and contributions of American medicine domestically and throughout the world, particularly as relates to pediatric gastroenterology, hepatology and nutrition.

PI_NAMEs: BAYRER, JAMES  (contact)

PROJECT_TITLE: Training Program in Pediatric Gastroenterology/Nutrition


NIH_SPENDING_CATS: Childhood Obesity;Contraception/Reproduction;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Nutrition;Obesity;Pediatric;Prevention

PI_NAMEs: WANG, CHRISTINA C. (contact)

PROJECT_TERMS: Academia;Affect;African;African American;Awareness;Biomedical Research;Body Weight decreased;California;Cardiovascular Diseases;cardiovascular risk factor;Child;Clinical Sciences;Collaborations;college;Communication;Communities;community academic partnership;community based participatory research;community engaged research;community engagement;Community Health;Community Health Education;Community Outreach;community partners;Conflict of Interest;conflict resolution;Daughter;design;Disease;disease phenotype;disease transmission;Education;Education and Outreach;Educational workshop;egg;Endowment;Environment;Epigenetic Process;epigenetic regulation;epigenome;epigenomics;Equity;evidence base;experience;Family;Future;Gene Expression;Gene Expression Regulation;Genomics;Glucose Intolerance;Goals;Hawaii;Health;health disparity;Health Promotion and Education;high school;high school program;High School Student;Hispanic;Hypertension;improved;Infrastructure;Institution;Insulin Resistance;intergenerational;Kidney Diseases;Knowledge;Lead;Life Style;Link;Los Angeles;male;Medical;Medical center;Metabolic Diseases;Metabolic syndrome;Methods;Modification;Names;National Center for Advancing Translational Sciences;Native Hawaiian;Native Hawaiian or Other Pacific Islander;Needs Assessment;Nevada;next generation;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;obesity management;offspring;operation;Pacific Islander;Parents;Phenotype;physical inactivity;Procedures;programs;Race;reproductive;Reproductive Health;Research;Research Institute;Research Personnel;Role;sperm cell;Stroke;Structure;summer program;Surveys;symposium;Texas;Translational Research;transmission process;Trust;Unhealthy Diet;Universities;university student;web site;working group;young adult;young man;young woman;Youth

PROJECT_TITLE: Community Outreach and Education Core (Core B)


PHR: Project Narrative The Animal Core (Core C) will provide all the mice needed by Projects 2 and 3.

PI_NAMEs: ZHENG, HUI  (contact)

PROJECT_TERMS: Aliquot;Animals;base;Bioinformatics;Breeding;cell type;Cells;Characteristics;Data;data quality;Development;Diet;Diet Monitoring;Ensure;Environment;epigenome;epigenomics;Euthanasia;Exercise;experimental study;Fatty acid glycerol esters;feeding;Female;Freezing;Generations;Genetic;Genomics;Glucose tolerance test;Goals;Health;Health Status;High Fat Diet;Housing;Human Resources;in vivo;Inbreeding;Insulin Resistance;Investigation;Islets of Langerhans;Label;Length;Liquid substance;Liver;Maintenance;male;Measurement;Metabolic;Mission;Monitor;Mouse Strains;Mus;Muscle;offspring;Partner in relationship;Phenotype;phenotypic data;Procedures;Publishing;reference genome;Reproducibility;reproductive;Research Personnel;response;RNA;RNA chemical synthesis;Running;sample fixation;Sampling;Services;Somatic Cell;sperm cell;Spermatogenic Cell;Testing;Testis;Time;Tissue Harvesting;Tissue Sample;Tissues;Tracer;Training;Transgenic Mice;Transgenic Organisms;Variant;Weight;Work

PROJECT_TITLE: Animal and Bioinformatics Core


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

PI_NAMEs: ZHOU, TONG  (contact)

PROJECT_TERMS: 3-Dimensional;Age;Alkylation;Animal Model;Animals;Archives;ATAC-seq;Base Sequence;Bioinformatics;bioinformatics tool;Biological Assay;Cell division;cell type;Cells;Chemicals;ChIP-seq;Chromatin;chromatin modification;computational pipelines;Cytosine;Data;Data Set;data sharing;Databases;design;Detection;Disease;DNA;DNA Methylation;DNA Modification Process;DNA Sequence;Enhancers;Environment;Enzymes;Epigenetic Process;epigenetic regulation;epigenome;epigenomics;Gene Expression;Gene Expression Profiling;Genes;Genetic Code;Genetic study;Genetic Transcription;Genome;genome browser;genome-wide;genomic locus;Genotype;Hi-C;High-Throughput Nucleotide Sequencing;histone modification;Histones;Human;human subject;Immunoprecipitation;Individual;Intercistronic Region;interest;intergenerational;Journals;Label;Libraries;Life Style;Link;Location;male;Mediating;Metabolic;Metabolic Diseases;Methylation;methylation pattern;Methyltransferase;Mission;Modification;Mus;next generation sequencing;Nucleic Acids;Nucleotides;offspring;Online Systems;Outsourcing;Pattern;Preparation;preservation;Process;promoter;Proteins;public database;reproductive;Research Personnel;Resources;Ribosomal RNA;RNA;RNA Sequences;Sampling;Series;Services;single cell analysis;single cell ATAC-seq;Sulfhydryl Compounds;transcriptome sequencing;transcriptomics;transgenerational epigenetic inheritance;translational impact;transmission process;United States National Institutes of Health;Untranslated RNA;Update;user-friendly;web server

PROJECT_TITLE: Center fro Male Reproductive Epigenomics


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Childhood Obesity;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Nutrition;Obesity;Pediatric;Prevention;Women's Health Research

ORG_CITY: EAST LANSING

ORG_DEPT: NUTRITION

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative The best predictor of obesity is having a mother with obesity, but the biological mechanisms that underlie this relationship are unknown. Using urinary and stool samples in addition to data from dyads stratified by maternal pre-pregnancy body mass index category, we will determine which biochemical pathways contribute to the development of childhood obesity. Further, we will be able to determine if those pathways differ according to maternal pre-pregnancy BMI.

PI_NAMEs: CASSIDY-BUSHROW, ANDREA E;COMSTOCK, SARAH S. (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: 2 year old;Acceleration;Adipose tissue;Affect;Age;Age Months;Antibiotics;antimicrobial;Antimicrobial Resistance;Bacteria;bacterial community;Biochemical Pathway;Bioinformatics;Biological;Birth;Blood Glucose;Blood Pressure;blood pressure elevation;Body mass index;Body Size;cardiometabolism;Categories;causal model;Child;cohort;combat;Communities;Conceptions;Data;Data Set;Deposition;Development;Diet;dietary;Dimensions;effective intervention;Energy harvesting;Energy Intake;Enrollment;Environment;Etiology;Exclusion;experimental study;falls;fasting blood glucose level;Feces;Future;gastrointestinal;Gastrointestinal tract structure;Gene Expression;Growth;gut microbiota;Health;infancy;Infant;Intervention;Knowledge;late life;Life;maternal obesity;maternal weight;Measures;Medical Records;member;Meta-Analysis;Metabolic;metabolic phenotype;metabolome;metabolomics;metagenomic sequencing;Methods;Michigan;Microbe;microbial;microbiota composition;mother nutrition;Mothers;Obesity;Obesity Epidemic;obesity in children;obesity prevention;obesity risk;offspring;offspring obesity;Overweight;Pathogenicity;Pathway interactions;Perinatal;Phenotype;postnatal;Pregnancy;prenatal;prepregnancy;prepregnancy obesity;prevent;Prevention;prospective;Public Health;Recommendation;recruit;Research;resistance gene;Risk;Risk Factors;Sampling;Shotguns;stool sample;Subgroup;Testing;Time;Underweight;unintended pregnancy;urinary;Weight;Weight Gain;Woman

PROJECT_TITLE: A Pre-, Peri-, and Post-natal Approach to Understanding the Risk and Mechanisms for Obesity


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Chronic Obstructive Pulmonary Disease;Emphysema;Lung;Machine Learning and Artificial Intelligence;Precision Medicine

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Chronic obstructive pulmonary disease (COPD), which includes conditions such as emphysema, is the fourth leading cause of death in the United States. New treatment/management options emerged recently (June 2018) when the FDA approved endobronchial valves (EBV) as a Breakthrough Device for the treatment of severe COPD. The goal of this proposal is to develop more robust, and quantitative criteria to identify patients that are likely to respond to EBV implantation.

PI_NAMEs: BROWN, MATTHEW S;GOLDIN, JONATHAN G;KIM, GRACE HYUN JUNG;MCNITT-GRAY, MICHAEL F (contact);NOO, FREDERIC

PROGRAM_OFFICER_NAME: HU, TOM CHIH-CHUANG

PROJECT_TERMS: Accounting;Affect;Air;Biological Markers;Blood Vessels;Breakthrough device;Cause of Death;Chronic Obstructive Pulmonary Disease;Clinical;clinical translation;Clinical Trials;Collaborations;Computer Vision Systems;Data;Data Set;density;Development;Devices;Disease;Effectiveness;Eligibility Determination;FDA approved;Goals;Heterogeneity;Image;Image Analysis;imaging biomarker;implantation;improved;inclusion criteria;Life Style;Lobar;Lobe;Lung;Lung Transplantation;Lung Volume Reductions;machine learning method;Measures;Methods;Modeling;Morbidity - disease rate;mortality;mortality risk;Outcome;Pathway interactions;Patient Selection;Patients;Perfusion;predicting response;predictive modeling;programs;Progressive Disease;Protocols documentation;Pulmonary Emphysema;Qualifying;quantitative imaging;reconstruction;Recording of previous events;Research;responders and non-responders;Severities;Severity of illness;Shortness of Breath;Standardization;Structure of parenchyma of lung;Testing;treatment trial;United States;Universities;ventilation;Work;X-Ray Computed Tomography

PROJECT_TITLE: Robust Clinical Translation of CT Imaging Biomarker in COPD for EBV Patient Selection

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Lung;Nutrition;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative We recently identified a novel structure in the airway lining of mice and humans. The cells in these mounded structures, which we have named hillocks for their shape, resist severe injury and act as stem cells that repair the lining of the airway. We propose to study the regulation and function of hillocks to understand how to promote airway repair and understand the role of hillocks in disease.

PI_NAMEs: RAJAGOPAL, JAYARAJ  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Ablation;Age;Airway Disease;airway epithelium;airway regeneration;airway repair;Apical;Applications Grants;Area;Attention;Basal Cell;Behavior;Bladder;Cartilage;cell motility;Cells;Chemicals;Chronic Obstructive Pulmonary Disease;Coupled;Cytokeratin;Dedications;design;Diffuse;Diphtheria Toxin;Disease;Epidermis;Epithelial Cells;epithelial repair;Epithelium;Genetic;Homeostasis;Human;Image;in vivo;injured airway;Injury;injury and repair;Label;Liver;Maintenance;Mediating;Metaplasia;migration;Modeling;Molecular;Morphology;mouse model;Mus;Names;Natural regeneration;novel;Play;Polyploid Cells;Polyploidy;Population;Pseudostratified Epithelium;Regulation;repaired;Reporting;Resistance;Role;severe injury;Shapes;Signal Transduction;Skin;Smoking;Smooth Muscle;Squamous Metaplasia;stem cell migration;stem cells;Stereotyping;Stratification;Stratified Epithelium;Structure;Surface;System;Trachea;Tretinoin;two-photon;Vitamin A;Vitamin A Deficiency

PROJECT_TITLE: Defining the lineage, mechanisms of maintenance, and function of a new injury-resistant airway epithelial structure: the hillock

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric;Primary Immunodeficiencies;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: STANFORD

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The proposed studies capitalize on new technologies and methods to map an important gene regulatory network which governs development of the human pharyngeal endoderm. Identification of the molecular mechanisms responsible for its typical and atypical development could reveal key intervention targets to ultimately prevent or treat 22q11 Deletion Syndrome.

PI_NAMEs: SEBASTIANO, VITTORIO  (contact)

PROJECT_TERMS: 22q11.2;Affect;Anatomy;Animal Model;Arteries;ATAC-seq;Binding;Biocompatible Materials;Biology;Branchial arch structure;Cell model;Cell Therapy;cell type;Cells;ChIP-seq;Chromatin;Chromosome 22;clinical phenotype;Congenital Heart Defects;craniofacial;CRISPR interference;Data;Development;developmental disease;DiGeorge Syndrome;Disease;Dissection;DNA;dosage;Endoderm;Endoderm Cell;Endothelium;Enhancers;Ensure;Epigenetic Process;epigenetic regulation;experimental study;Face;Gene Deletion;Gene Expression;gene regulatory network;Generations;Genes;Genetic;Genetic Screening;Genetic Transcription;genetic variant;genome sequencing;Heart;Heterozygote;Histones;Human;human embryonic development;human embryonic stem cell;human model;human tissue;In Vitro;in vitro Model;in vivo;insight;Intervention;Knowledge;Maps;Mesoderm;Methods;microdeletion;Modeling;Molecular;multidisciplinary;Mus;Muscle;Mutation;Neural Crest Cell;new technology;novel;Nucleic Acid Regulatory Sequences;Parathyroid gland;Pathway interactions;Patients;Pattern;pharmacologic;Pharyngeal Apparatus;pharyngeal patterning;Pharyngeal structure;Phase;Phenotype;Physiological;Play;Population;prevent;Qi;reconstruction;Regulation;response;Role;Signal Transduction;stem cell biology;Structure;Syndrome;System;Testing;Thymus Gland;Tissues;tool;transcription factor;transcriptome;transcriptome sequencing;Validation;whole genome;Work

PROJECT_TITLE: Dissecting the Molecular Role of TBX1 in the Context of Human Pharyngeal Endoderm Development

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Bioengineering;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Prevention

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative The proposed research is relevant to public health because it can result in enhanced critical care workflow and early critical care intervention, ultimately improving patient outcomes and decreasing hospitalization costs. Thus, the proposed research is relevant to the part of NIH's mission that pertains to advancing disease diagnosis through medical applications of new tools and technologies, as the proposed research applies advanced computational methods and sensing technologies to automatically quantify and convey patient status in real-time.

PI_NAMEs: BIHORAC, AZRA ;RASHIDI, PARISA  (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Acute;advanced disease;Affect;Algorithms;Biological Markers;brain dysfunction;circadian;Circadian desynchrony;Circadian Dysregulation;circadian regulation;Clinical;clinical care;Clinical Data;clinical decision-making;Clinical Informatics;Collaborations;Coma;Computing Methodologies;cost;Critical Care;Critical Illness;Cues;Data;Data Set;data sharing;deep learning;deep learning algorithm;deep learning model;Delirium;disease diagnosis;dynamic system;Electronic Health Record;Environment;Fostering;Frequencies;high risk;Hospital Costs;Human;Image;Immobilization;Impaired cognition;improved;innovation;Intensive Care Units;Intervention;Light;light intensity;Medical;Medicine;Mission;Modeling;Monitor;mortality;Neurology;Noise;noise exposure;Nonpharmacologic Therapy;novel;novel strategies;Observational Study;Outcome;Pain;patient mobility;Patient-Focused Outcomes;Patients;pharmacologic;Physicians;Physiological;predictive modeling;pressure;Prevention;Prevention strategy;Process;prospective;Provider;Public Health;real time monitoring;Reproducibility;Research;Risk Factors;Sampling;satisfaction;sensor;sensor technology;Sleep disturbances;sound;Syndrome;System;Techniques;Technology;Testing;Time;tool;United States;United States National Institutes of Health

PROJECT_TITLE: ADAPT: Autonomous Delirium Monitoring and Adaptive Prevention

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-E(09)]


ORG_CITY: HADLEY

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: Project Narrative We have discovered two new sperm incubation methods based on the regulation of intracellular calcium and metabolic pathways; these methods improve sperm functional parameters which increase the percentage eggs that can be fertilized in vitro and also improve early embryo development and pregnancy rates. From the basic science perspective, this proposal is aimed to understand at the molecular level how intracellular calcium and metabolism interact to enhance sperm function. From the applied point of view, accomplishment of these goals will provide tools for improving current Assisted Reproductive Technology (ART) methods including in vitro fertilization and early embryo development.

PI_NAMEs: VISCONTI, PABLO E. (contact)

PROJECT_TERMS: Affect;Age;Animals;Artificial Insemination;Assisted Reproductive Technology;Back;Basic Science;blastocyst;Bypass;Calcium;Cell division;Couples;Data;design;Development;Economics;egg;Embryo;Embryo Transfer;Embryonic Development;Environmental Risk Factor;Event;experience;experimental study;Exposure to;Female;female reproductive tract;Fertilization;Fertilization in Vitro;Gene Expression;Genetic;genetic approach;Genetic Models;Germ Cells;Glycolysis;Goals;Health;Human;human disease;human model;Implant;implantation;improved;In Vitro;Incubated;Individual;Infertility;Injections;insight;Intracytoplasmic Sperm Injections;intrauterine insemination;Ionophores;Knock-out;Mammals;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methodology;Methods;Molecular;Motility;mouse model;novel;Nutrient;Obesity;offspring;Output;Oxidative Phosphorylation;Pathway interactions;Phosphorylation Inhibition;Physiological;post pregnancy;Pregnancy;Pregnancy Rate;Procedures;Process;programs;Protocols documentation;Publishing;pup;Recovery;Regulation;response;Signal Pathway;Signal Transduction;Site;spatiotemporal;sperm cell;sperm cryopreservation;sperm function;Sperm Motility;Starvation;Sterility;subfertility;Techniques;Test-Tube Baby;Testing;tool;Translating;Uterus;zygote

PROJECT_TITLE: Sperm Ca2+ signaling and energy pathways in basic science and ART

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Transplantation

PHR: NARRATIVE This training program will develop young scientists and physician-scientists interested in working transplantation, at the interface between basic science and clinical application, as outstanding independent investigators with a broad understanding of the basic and translational sciences that form the foundation of this field. The Harvard Medical School environment encompasses all aspects of transplantation, from the most basic laboratory investigations to clinical applications in the operating room, and therefore provides a unique opportunity for training in this area. To accomplish this important goal, we have assembled an exceptional faculty team with diverse and complementary research interests, a successful record of collaboration, and a commitment to the training of young investigators.

PI_NAMEs: MADSEN, JOREN C (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Biology;Training;Transplantation

PROJECT_TITLE: Training in Transplantation Biology

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ED_INST_TYPE: HOSPITALS

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Overall Program -  Narrative (Genetics and Biology of Pancreatic Ductal Adenocarcinoma)    Pancreatic  cancer  will  be  the  second  leading  cause  of  cancer death  in 15  years and  remains  incurable.    This  program project aims to identify therapeutic intervention points through various state- of- the- art technologies and  animal modeling. The goal remains to gain sufficient understanding of PDAC genetics and biology to inform the  implementation of effective therapeutic combinations.

PI_NAMEs: DEPINHO, RONALD ANTHONY (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: Animal Model;Antitumor Response;Automobile Driving;Autophagocytosis;Biological Models;Biology;Bypass;cancer cell;Cancer Cell Growth;Cancer Etiology;cancer immunotherapy;Cell Communication;Cell Physiology;Cells;Cellular Metabolic Process;Cessation of life;checkpoint inhibition;Clinical;Clinical Investigator;Clinical Trials;Collagen Type I;Combination immunotherapy;Complex;Data;Data Aggregation;Data Analyses;Degradation Pathway;Dependence;Development;Disease remission;exhaust;exosome;Extinction;Fibroblasts;Gene Mutation;Genetic;Genetically Engineered Mouse;Genotype;Goals;granulocyte;Histopathology;Homeostasis;Human body;IL8RB gene;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune Evasion;Immune response;Immunity;Immunotherapy;improved;Inflammatory;inhibition of autophagy;innovation;insight;Integrins;Investigation;Investigational Therapies;KRAS oncogenesis;KRAS2 gene;Lysosomes;Maintenance;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Metabolic;Metabolism;Mitochondria;Modeling;monocyte;mouse model;multidisciplinary;Multiomic Data;Mus;Mutate;Mutation;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;neoplastic cell;novel;novel therapeutics;Oncogenes;Oncogenic;Organoids;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;paracrine;Paracrine Communication;Pathogenesis;Pathology;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Play;Population;preclinical trial;prevent;Program Research Project Grants;programs;Published Comment;Regimen;Regulation;Research Personnel;Resistance;resistance mechanism;Role;Series;Signal Transduction;synergism;System;targeted treatment;Technology;technology platform;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;Time;Tissues;Translating;tumor;tumor growth;Tumor Immunity;tumor initiation;tumor metabolism;tumor microenvironment;tumor progression;Tumor Suppressor Proteins;Tumor-Infiltrating Lymphocytes;Variant;Work


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Genetics;Immunotherapy;Pancreatic Cancer;Rare Diseases

PHR: Project 1 -  Project Narrative  Pancreatic cancer is one of the deadliest cancer types in the United States with no effective therapy developed  to date. During our previous funding cycles, this research project in close collaboration with our P01 team has  elaborated the function of KRAS, the central driver for pancreatic cancer, and identified essential roles of the  crosstalk between tumor cells and their environment for the support of cancer- relevant growth. In this next cycle,  this project will continue to work with our Projects and Cores in a highly integrated fashion to perform in- depth  studies on the role of the tumor immune microenvironment in the regulation of KRAS- dependence and response  to immunotherapies, with a goal of rapidly translating our basic discoveries into clinical trials that will eventually  benefit pancreatic cancer patients suffering from this dreadful disease.

PROJECT_TERMS: Agonist;Alleles;antagonist;Antibodies;Biology;Bypass;cancer cell;Cancer Cell Growth;cancer stem cell;cancer type;CCL2 gene;CCL7 gene;Cell Physiology;Cell Survival;Cells;checkpoint inhibition;Clinical Trials;Collaborations;Combination immunotherapy;Combined Modality Therapy;Computational Biology;cytokine;Cytotoxic T-Lymphocytes;Dependence;Development;Disease;effective therapy;Effectiveness;Engineering;Environment;Epithelium;evidence base;exosome;experimental study;Extinction;first-in-human;Foundations;Funding;Future;Genetic;Genetic study;Glycolysis;Goals;Grant;granulocyte;Growth;HDAC5 gene;Human;IL8RA gene;Immune;immune checkpoint;immune checkpoint blockade;Immune Targeting;Immunity;immunoregulation;Immunosuppression;Immunotherapy;improved;in vivo;independency;Infiltration;inhibitor;innovation;insight;Interleukin 8A Receptor;Intervention;Invaded;Knowledge;KRAS oncogenesis;KRAS2 gene;KRASG12D;Macrophage;Maintenance;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Mediator;Metabolic;Metabolism;Modeling;Molecular;Molecular Analysis;Monoclonal Antibodies;monocyte;mouse model;mutant;Mutation;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;neoplastic cell;neutrophil;novel;novel therapeutic intervention;novel therapeutics;Nutrient;Outcome;Pancreas;Pancreatic Adenocarcinoma;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;paracrine;Pathology;Pathway interactions;pharmacologic;Population;Pre-Clinical Model;preclinical study;prevent;rational design;recombinase;Regimen;Regulation;Relapse;Research Project Grants;Resistance;resistance mechanism;response;RNA Interference;RNA Interference Therapy;Role;Secure;Signal Transduction;Suppressor Mutations;T-Lymphocyte;Therapeutic;therapy development;TP53 gene;Transforming Growth Factor beta;Translating;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Suppressor Proteins;tumor-immune system interactions;United States;Validation;Work

PROJECT_TITLE: Project 1- Elucidating oncogenic KRAS in PDAC cell signaling, resistance and immunity