NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Obesity;Physical Activity;Prevention;Primary Health Care;Rural Health;Social Determinants of Health

PHR: Public Narrative. Given the rural/urban disparity in cancer incidence and mortality and matching disparity in physical inactivity, the goal of the PA Moves Trial is to increase physical activity among rural Pennsylvanians. A multi-level intervention will address physical inactivity at the level of organizations (health care systems), communities (with assessment and promotion of community resources), and individuals (counseling from a physician and from a community source). This group randomized trial will partner with rural primary care clinics, the YMCA, and Penn State Extension to increase physical activity in rural Pennsylvania.

PI_NAMEs: RUFFIN, MACK T.;SCHMITZ, KATHRYN H. (contact)

PROGRAM_OFFICER_NAME: BERRIGAN, DAVID

PROJECT_TERMS: Address;Adult;Appointment;Behavioral;Breast;built environment;cancer health disparity;cancer risk;Chronic Disease;Clinic;Cohort Effect;Collaborations;Colon;Colorectal Cancer;Communities;community advisory board;Computerized Medical Record;Counseling;Diabetes Mellitus;digital intervention;Disparity;Education;Ensure;Environment;Exposure to;Faculty;fitness intervention;Goals;Health;Health Benefit;health communication;Health Professional;Health system;Healthcare Systems;implementation evaluation;Incidence;Individual;instrument;Intervention;intervention cost;Learning;Location;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Methodology;Methods;Modeling;moderate-to-vigorous physical activity;mortality;mortality disparity;Obesity;Outcome;Overweight;Participant;Patients;Pennsylvania;Physical activity;Physical assessment;physical inactivity;Physicians;Population;Positioning Attribute;Primary Care;primary care clinic;primary care practice;primary care provider;Primary Health Care;programs;Provider;Qualifying;quitline;RALA gene;Randomized;randomized trial;Recommendation;Reporting;Research;Resources;Risk;Risk Factors;Rural;rural America;rural dwellers;rural setting;smoking cessation;social;Social Environment;Source;Specialist;success;Techniques;Technology;Telephone;Training;Trust;urban disparity;Work

PROJECT_TITLE: Increasing Physical Activity in Rural Pennsylvanians: The PA Moves Trial


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Estrogen;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Transgender women (TGW) frequently use estrogen-based gender affirming hormonal therapies (GAHT) to promote feminization and decrease gender dysphoria. A highly vulnerable population, TGW are 49-times more likely to acquire HIV as compared to cisgender men and women; therefore, pre-exposure prophylaxis (PrEP, tenofovir disoproxil fumarate/emtricitabine), which prevents HIV acquisition in high-risk populations, is greatly needed by TGW. Because the interaction between GAHT and PrEP is poorly understood, an investigation on the impact of exogenous hormonal therapies on PrEP effectiveness (and vice versa) is required to optimize dosing regimens for HIV protection, while also not impacting the effects of GAHT on reducing gender dysphoria.

PI_NAMEs: MARZINKE, MARK A (contact)

PROGRAM_OFFICER_NAME: PORTER, KRISTEN AMY

PROJECT_TERMS: Ablation;Address;Adherence;Adult;Age;AIDS prevention;Anal Sex;Area;Behavioral;Blood;Caring;cis-female;cis-male;Clinical;Clinical Trials;Colorectal;Communities;Counseling;cultural competence;Data;design;Discrimination;Dose;Drops;Drug Interactions;Drug Kinetics;Effectiveness;efficacy evaluation;Employment;emtricitabine;Enrollment;Ensure;Estrogen Therapy;Estrogens;experience;Face;falls;Feminization;Formulation;Fumarates;Future;gender affirmation;gender dysphoria;gender nonconforming;gender transition;Goals;Health;Healthcare;high risk;high risk population;HIV;HIV Infections;Hormonal;hormone therapy;Hormones;improved;In Vitro;Individual;Investigation;Knowledge;Medical;member;men who have sex with men;Mental Depression;Methods;Modeling;Operative Surgical Procedures;Oral;Outcome;Persons;Pharmaceutical Preparations;pharmacodynamic model;pharmacologic;Pharmacology;Pharmacotherapy;Phase;Plasma;Population;pre-exposure prophylaxis;Predisposition;Pregnancy;Prevalence;prevent;Professional Organizations;Prophylactic treatment;Publishing;Quality of life;Randomized;Recommendation;Regimen;Relative Risks;Renal function;Reporting;reproductive;Research;Risk;Risk Reduction;Role;simulation;Tenofovir;Testing;Testosterone;Tissues;transgender;transgender women;Treatment Efficacy;trial design;uptake;Urine;Viral;Visit;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Improving PrEP protection of transgender women through mechanistic pharmacokinetic understanding

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: AG

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Aging blood-based biomarkers (assays: IL-6, TNFa, CRP, GDF15, IGF-1, Cystatin C, NT-proBNP, and hbA1c), DNA methylation (Illumina EPIC chip), and gene expression (RNA Seq) provide an opportunity to detect aging related diseases and identify mechanisms linking earlier exposures to later life health. However, little is known about how these aging biomarkers correlate with each other, the environment, or health over the life course. This project uses data from three large nationally representative panel studies to examine these associations over the life course: the Health and Retirement Study (biomarker data for ages 51-110), the National Longitudinal Study of Adolescent to Adult Health (biomarker data ages 24-42) and the Fragile Families and Child Wellbeing Study (biomarker data ages 9-22).

PI_NAMEs: FAUL, JESSICA ;GAYDOSH, LAUREN M;MITCHELL, COLTER M.S. (contact)

PROGRAM_OFFICER_NAME: BRAUDT, DAVID BRUCE

PROJECT_TERMS: Address;Adolescent;Adult;Age;age related biomarkers;age-related disease;Aging;aging biomarker;aging process;aging related disease;Area;biobank;Biochemistry;Biological Aging;Biological Assay;Biological Markers;biological specimen archives;biomarker validation;Birth;Blood Chemical Analysis;Blood Pressure;blood-based biomarker;Body mass index;Cells;Child Welfare;Childhood;Cities;clinical practice;Cognition;cohort;Communities;contextual factors;cost;Data;data harmonization;Data Set;demographics;Detection;Disease Progression;DNA Methylation;Early Diagnosis;Environment;Ethnic Origin;Exposure to;Family;family structure;GDF15 gene;Gene Expression;Generations;Glycosylated hemoglobin A;Health;Health and Retirement Study;Healthcare;healthspan;Immune;Individual;insight;Insulin-Like Growth Factor I;Interleukin-6;Intervention;late life;Life;Life Cycle Stages;Link;Longevity;Longitudinal Studies;Measures;Mediating;Mental Health;Methods;Methylation;middle age;National Longitudinal Survey of Adolescent to Adult Health;Outcome;Patient Self-Report;Phenotype;Physiological;Population;post gamma-globulins;Poverty;Prevalence;Prevention;pro-brain natriuretic peptide (1-76);Production;Quality Control;Race;rate of aging;Research;Research Personnel;RNA;Sampling;secondary analysis;sex;Signal Transduction;social adversity;Social Environment;Societies;sociodemographics;Socioeconomic Status;Subgroup;Surveys;Symptoms;Testing;transcriptome sequencing;Trauma;traumatic event

PROJECT_TITLE: Biological Aging Across the Life Course: Harmonizing Cohort Biospecimen Archives

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-C(02)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Complementary and Integrative Health;Depression;Mental Health;Mental Illness;Microbiome;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROGRAM NARRATIVE Many households include a pet, but whether pets have a positive impact on the mental health and psychological distress of their owners has not been studied rigorously. We will conduct the first prospective study to investigate whether pet ownership and attachment are associated with incident depression and psychological distress in two large US cohorts. In addition, we will explore the role of the gut microbiome and metabolome in these associations, and take first steps towards an embedded longitudinal study of pets and their feces microbiome, for future HAI studies.

PI_NAMEs: SCHERNHAMMER, EVA S (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: 14 year old;Address;Adolescence;Adult;Age;aged;Anaerobic Bacteria;Animals;Anxiety;Biological Markers;Canis familiaris;center for epidemiological studies depression scale;Child;Childhood;Chronic;cohort;Collection;cost;Crowns;Data;dehydroepiandrosterone;depressive symptoms;Diet;Dimensions;disability;Distress;Emotional;Enrollment;evidence base;Feces;Felis catus;Female;follow-up;Future;Generalized Anxiety Disorder;Goals;gut microbiome;Health;Home;hormone metabolism;Household;Human;Hydrocortisone;immunoregulation;improved;indexing;Individual;Inflammatory;insight;Life Style;Longitudinal cohort;longitudinal dataset;Longitudinal Studies;male;Measures;Mediating;Mental Depression;Mental Health;metabolome;Microbe;microbial;microbiome;microbiota;mind/body;neurotransmitter metabolism;novel;novel therapeutic intervention;Nurses;Nurses' Health Study;Outcome;Ownership;Parents;Participant;Pathway interactions;Personality;pet animal;Population Study;Prevention strategy;Preventive;Preventive measure;prospective;Prospective Studies;psychological distress;Psychosocial Assessment and Care;Psychosocial Stress;Research;Risk;Risk Reduction;Role;Salivary;Source;stool sample;Stress;Taxonomy;Time;Volatile Fatty Acids;Weight;Woman;young adult

PROJECT_TITLE: Mechanistic pathways of the effects of human-animal interaction on depression and psychosocial stress


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: TAMPA

ORG_NAME: JAMES A. HALEY VA MEDICAL CENTER

ORG_STATE: FL

PHR: The current proposal is focused on hypertension and chronic kidney disease (CKD), which are among the most common chronic conditions for which Veterans seek medical care. Hypertension causes one-third of CKD cases, but the needs for its prevention and treatment are largely unmet. The current study aims to determine the mechanisms contributing to metabolic rewiring in the kidney using a rat model of salt-sensitive hypertension, the Dahl SS rat, a widely used model of salt-induced hypertension and CKD. This proposal represents a pioneering effort to understand the mechanisms regulating metabolic states in the kidney and further pathological changes associated with altered proximal tubule function during the development of salt-sensitive hypertension and CKD. Mechanistic insight into the protective effects of L-Lysine will be uncovered.

PI_NAMEs: STARUSCHENKO, ALEXANDER  (contact)

PROJECT_TERMS: absorption;Active Biological Transport;Acute;Albumins;Animal Feed;ATP Synthesis Pathway;Caring;Cells;Chemicals;Chronic;Chronic Kidney Failure;Complex;Dahl Hypertensive Rats;Development;dietary;Dietary Intervention;Dietary Supplementation;Diuretics;Enzymes;Essential Amino Acids;Excretory function;experimental study;fatty acid biosynthesis;fatty acid metabolism;fatty acid oxidation;Filtration;Functional disorder;Genetic;glomerular filtration;Growth;high salt diet;Hypertension;hypertensive;Immune system;improved;inhibitor;Injury to Kidney;innovation;insight;Kidney;Kidney Diseases;Long-Term Effects;Lysine;Malonyl Coenzyme A;Mediating;Medical;men;Metabolic;Metabolic Pathway;metabolic phenotype;Metabolic stress;Metabolic syndrome;Metabolism;metabolomics;Mitochondria;mitochondrial metabolism;Modeling;Nonesterified Fatty Acids;novel;Oxidative Stress;Pathogenicity;Pathologic;Pathway interactions;pharmacologic;Physiological;Plasma;Play;Post-Translational Protein Processing;Prevention;Production;Property;protective effect;Rattus;Regulation;renal damage;Renal function;Reporting;Research;Risk;Role;salt sensitive hypertension;saluretic;Supplementation;Support System;Testing;Therapeutic;uptake;Veterans

PROJECT_TITLE: Transport and metabolism in the kidney

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 NEPH-N (01)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: TULSA

ORG_NAME: LAUREATE INSTITUTE FOR BRAIN RESEARCH

ORG_STATE: OK

PHR: PROJECT NARRATIVE Our project focuses on understanding how human social connections shape the human brain during adolescence, a period of significant social reorientation. The COVID pandemic struck in the midst of the ongoing Adolescent Brain Cognition Development (ABCD) study, providing a unique set of pre-pandemic, peri- pandemic, and post-pandemic assessments on adolescents who experienced a disruption in social connectedness, especially with their peers. In this project, we propose to use our developed novel statistical approaches on the unique ABCD datasets utilizing brain imaging, genetic, mood, and behavior assessments to investigate the neurobiological underpinnings of different domains of social connectedness and how the disruption of social connectedness impacts neurodevelopment and emotional wellbeing in youth.

PI_NAMEs: BAKER, FIONA C;FAN, CHUN CHIEH  (contact);THOMPSON, WESLEY KURT

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: 14 year old;Adaptive Behaviors;Address;Adolescence;Adolescent;advanced analytics;Affective;analytical tool;Behavior assessment;Behavioral;Biosocial;Brain;Brain imaging;Buffers;clinical practice;Cognition;Cognitive;cognitive development;Complex;COVID-19 pandemic;Data;Data Analyses;Data Set;Development;Diffusion Magnetic Resonance Imaging;Emotional;Emotions;Ensure;Equilibrium;experience;experimental study;family support;follow up assessment;follow-up;Functional Magnetic Resonance Imaging;Genetic;Genetic Predisposition to Disease;Goals;Home;Human;Image;improved;Individual;information processing;innovation;insight;interest;Loneliness;Long-Term Effects;longitudinal analysis;Longitudinal cohort;Magnetic Resonance Imaging;Measures;Mediating;Mental Depression;Mental Health;mentalization;Methods;Moods;multidimensional data;Multimodal Imaging;multimodality;neural;neural network;neurobiological mechanism;Neurobiology;neurodevelopment;Neurotic Disorders;novel;Outcome;pandemic disease;pandemic disruption;pandemic impact;Participant;peer;Personal Satisfaction;Phenotype;Play;Population;post-pandemic;pre-pandemic;Process;programs;prospective;psychosocial;Public Health;public health intervention;Research;Resources;response;Rest;Role;Sampling;Scanning;Scoring Method;sex;Shapes;Site;sleep quality;social;Social Behavior;Social Conditions;social culture;Social Environment;social factors;Social Interaction;Social Protection;social relationships;Social support;Structure;Subgroup;Surveys;System;Therapeutic;tool;Well in self;Work;Youth

PROJECT_TITLE: Effects of pandemic-related disruption to social connectedness on the brain and emotional wellbeing in adolescents


ORG_CITY: SALT LAKE CITY

ORG_NAME: VA SALT LAKE CITY HEALTHCARE SYSTEM

ORG_STATE: UT

PHR: Thrombosis, or blood clots, complicates inflammatory syndromes such as sepsis, and may contribute to organ failure and death in Veterans. Sepsis is caused by infections, including bacteria and viruses. Sepsis can result in widespread inflammation and, in severe cases, death and disability. Small circulating cells in the bloodstream, called platelets, mediate inflammation and blood clotting during sepsis. We have found that sepsis increases interferon-responsive genes in platelets and their parent cells, megakaryocytes. Interferon is an inflammatory cytokine that is usually increased during sepsis. We have also found that one of these interferon-regulated genes, called IFITM3, controls the movement of proteins in platelets and megakaryocytes. Our studies will examine how IFITM3 controls protein movement in cells to regulate blood clotting during inflammation and sepsis. Our research will help us understand why blood clotting occurs in Veterans during sepsis and other inflammatory diseases. We may also find new ways to prevent blood clotting from occurring.

PI_NAMEs: RONDINA, MATTHEW THOMAS (contact)

PROJECT_TERMS: adverse outcome;Affect;Alleles;Alpha Granule;Autophagosome;Award;Bacteremia;Bacteria;Biology;Blood Circulation;Blood coagulation;Blood Platelets;Cardiovascular Diseases;cardiovascular disorder risk;Cell membrane;Cell Physiology;cell type;Cells;Cessation of life;Clinical;Complication;cytokine;Cytoplasmic Granules;Data;disability;Disease;Endocytosis;Endosomes;Event;experimental study;extracellular;Fibrinogen;Genes;Genetic;Hemostatic Agents;Hospitals;Human;Hydrophobicity;Immune;Immune response;In Vitro;in vivo;Infection;Inflammation;Inflammatory;innovation;Integral Membrane Protein;Interferon alpha;Interferons;Intracellular Membranes;loss of function;loss of function mutation;Lysosomes;Malignant Neoplasms;Mediating;Megakaryocytes;Membrane;Minor;Modeling;Molecular;Morbidity - disease rate;Movement;Mus;new therapeutic target;novel therapeutics;Organ failure;Organelles;Parents;Pathway interactions;Patients;pharmacologic;Platelet aggregation;platelet function;prevent;Protein Secretion;Proteins;Reproducibility;Research;response;Risk;Role;Sampling;Sepsis;septic patients;Sorting;stem cells;Stress;Stroke;Structure;Syndrome;Testing;thromboinflammation;Thrombosis;thrombotic;thrombotic complications;Thrombus;trafficking;Up-Regulation;vesicular SNARE proteins;Veterans;Viral Physiology;Virus;Virus Diseases;Work

PROJECT_TITLE: Platelet Reprogramming During Inflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 HEMA-G (01)]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Immunotherapy;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROLOGY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: Narrative Current therapies for multiple sclerosis (MS) suppress the immune system in general, which can cause serious side effects. We propose to study the use of particles (extracellular vesicles) released by cells that produce myelin, which is damaged by the immune system in MS. Our findings in MS-like disease in mice show that these particles suppress immunity against myelin, without general suppression of the immune system, which would be advantageous over current therapies for MS.

PI_NAMEs: ROSTAMI, A.M.  (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Address;Animal Model;Animals;Antigen Presentation;Antigen Targeting;Antigens;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;Cell Line;Cells;Chronic;Clinical;clinically relevant;CNS autoimmunity;conditional knockout;Data;Development;Disease;Epitope spreading;Epitopes;Evolution;Experimental Animal Model;Experimental Autoimmune Encephalomyelitis;extracellular vesicles;Failure;Flare;Genetic;Goals;Heterogeneity;Human;humanized mouse;Immune response;Immune system;immune system function;Immune Targeting;Immune Tolerance;Immunity;Immunization;immunoregulation;Immunosuppression;in vivo;Interferon Type II;Interferons;Interleukin-10;Intravenous;intravenous administration;intravenous injection;Knockout Mice;Knowledge;Mediating;Modeling;Multiple Sclerosis;multiple sclerosis patient;multiple sclerosis treatment;Mus;Myelin;Myelin Proteins;neuroinflammation;Nose;novel therapeutics;Oligodendroglia;Oral;particle;Pathogenesis;Pathogenicity;Patients;Peptides;Peripheral;peripheral tolerance;Production;programmed cell death ligand 1;prophylactic;reconstitution;Research;response;Rest;Role;Route;Serious Adverse Event;side effect;Specificity;success;System;Testing;Therapeutic;Therapeutic Agents;Therapeutic Effect;Time;Translations;Treatment Efficacy;Uncertainty

PROJECT_TITLE: Oligodendrocyte extracellular vesicles: a novel therapy for CNS autoimmunity

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Brain Disorders;Cerebral Palsy;Chronic Pain;Clinical Research;Disability Research;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pain Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rehabilitation

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Individuals with cerebral palsy (CP) suffer disproportionately from chronic pain. Although the burden of chronic pain is well documented, our scientific understanding of sensorimotor function in relation to sensory loss and gain and pain mechanisms is limited. Studying sensory function by modifying quantitative sensory testing will advance an integrated approach to pain assessment and, in the long run, improve pain treatment decision making for CP.

PI_NAMEs: SYMONS, FRANK J (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Acute;Address;Adolescent;Affect;Appearance;Biological Markers;Calibration;Caring;Central Nervous System;Cerebral Palsy;Characteristics;chemokine;Child;Childhood;Chronic;chronic pain;Clinical;Clinical assessments;clinical care;Complex;cytokine;Data;Data Set;Decision Making;demographics;design;Developmental Disabilities;disability;Discrimination;Electroencephalography;Epidemiology;Epilepsy;Etiology;Fiber;Functional disorder;Future;Genetic;Grouping;Guidelines;Health;Health Care Costs;Heterogeneity;high risk;High-dimensional Modeling;Impairment;improved;Individual;individual variation;Inflammation;Inflammatory;Literature;Logic;loss of function;Measurement;Mechanics;Medical;Modality;Modeling;Motor;Motor disability;Neurodevelopmental Disability;Neurodevelopmental Disorder;Nociception;novel;novel strategies;Operative Surgical Procedures;Outcome;Outcome Study;Pain;Pain management;Pain Measurement;pain outcome;Pain Research;painful neuropathy;Patients;Perception;Phenotype;Population;postnatal;Protocols documentation;Proxy;Public Health;Quality of life;Recording of previous events;Reporting;Reproducibility;Research;saliva sample;Sampling;Scientific Advances and Accomplishments;secondary outcome;Sensorimotor functions;Sensory;sensory mechanism;sensory stimulus;Severities;sex;Shapes;Standardization;Stress;Subgroup;Tactile;Techniques;Testing;Texture;Time;tool;Translating;Validation;Work

PROJECT_TITLE: Sensory Function and Chronic Pain in Cerebral Palsy

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Cystic Fibrosis;Infectious Diseases;Lung;Rare Diseases

ORG_CITY: CLEMSON

ORG_DEPT: BIOLOGY

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: Project Narrative Human infections are frequently polymicrobial, with interactions between microbes leading to increased disease severity. The primary objective of this project is to define how interactions between Aspergillus fumigatus, a major fungal pathogen in cystic fibrosis disease, and co-infecting microbes such as Pseudomonas aeruginosa alter A. fumigatus physiology and enhance human respiratory infections. The goal of this work is to design new therapeutic strategies that can interfere with these microbial interactions and improve disease outcomes.

PI_NAMEs: DOLAN, STEPHEN K (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Acceleration;anti-fungal agents;anti-microbial drug;Area;Aspergillus fumigatus;Behavior;Characteristics;Chronic;chronic infection;Clinical;Coculture Techniques;Communication;comparative;confocal imaging;Cystic Fibrosis;cystic fibrosis infection;cystic fibrosis patients;Cystic Fibrosis sputum;Data;design;Development;Disease;Disease Outcome;Drug Metabolic Detoxication;Environment;Exhibits;Exposure to;Foundations;Future;genetic approach;Genomics;Gliotoxin;Goals;Growth;Heterogeneity;Human;Hydrogen Cyanide;Immune response;Immune system;improved;In Situ;in vitro Model;Infection;infection risk;innovation;Investigation;Laboratories;Life;Lung;Mediating;Mediator;Metabolic;Metabolic Pathway;Microbe;Microbial Biofilms;Microbial natural product;microorganism;microorganism interaction;Modeling;Molecular;mortality;Mucous body substance;multiple omics;Mutation;Mycoses;novel therapeutic intervention;Nutrient;Nutritional;Nutritional Requirements;opportunistic pathogen;Organism;pathogen;Pathogenesis;pathogenic bacteria;pathogenic fungus;Pattern;Persons;Physiological;Physiology;predictive modeling;Predisposition;Production;programs;Proliferating;Property;Pseudomonas aeruginosa;Pulmonary Cystic Fibrosis;pulmonary function;Reaction;Research;Research Personnel;Respiratory System;Respiratory Tract Infections;response;reverse genetics;secondary metabolite;Severity of illness;Stress;Technology;Testing;Toxin;transcriptomics;Translating;Virulence;Viscosity;Work

PROJECT_TITLE: Defining mechanisms of fungal-bacterial interactions during infection

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project narrative The science of dissemination and implementation (D&I) aims to shorten the translation gap from discovery to impact of evidence-based interventions in real world community and clinical settings. Mentored Education for Dissemination and Implementation Science (MEDIS) will provide researchers with advanced training through a 5-day short course offered annually and combined with ongoing mentorship. This training of the next generation of D&I researchers will improve the adoption of behavioral and social science interventions that may eliminate chronic disease disparities.

PI_NAMEs: BROWNSON, ROSS C;HAIRE-JOSHU, DEBRA  (contact)

PROGRAM_OFFICER_NAME: ARTIS DICKERSON, SHAVON

PROJECT_TERMS: Address;Adoption;Adult;Affect;American;Behavior Therapy;behavioral and social science;burden of chronic illness;Cardiovascular Diseases;career;career development;Cause of Death;Characteristics;Chronic;Chronic Disease;Clinical;Communities;community partners;Competence;Diabetes Mellitus;disability;Disease;disease disparity;Disparity;Dissemination and Implementation;dissemination science;Economic Factors;Education;ethnic minority population;evidence base;Evidence based intervention;experience;Faculty;faculty mentor;Fostering;Health;Health Care Costs;Health Promotion;Healthcare Systems;Heart Diseases;human old age (65+);implementation research;implementation science;improved;Individual;innovation;Institution;Intervention;Knowledge;Learning;Life Style;low socioeconomic status;Malignant Neoplasms;Mentors;Mentorship;Methods;Morbidity - disease rate;mortality;multiple chronic conditions;Neighborhoods;next generation;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Persons;physical inactivity;Political Factor;Population;population health;prevent;programs;racial discrimination;racial minority population;recruit;Reporting;Research;Research Personnel;Risk Factors;Science;social health determinants;social science research;Socioeconomic Status;Strategic Planning;Stroke;Targeted Research;Taxes;Teacher Professional Development;Tobacco use;Trainers Training;Training;Translations;Unhealthy Diet;United States;United States National Institutes of Health;Work;young adult

PROJECT_TITLE: Mentored Education for Dissemination and Implementation Science (MEDIS) Program


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: MISCELLANEOUS

PHR: PROJECT NARRATIVE Promoting health-enhancing and sustainable physical activity levels across childhood and adolescence contributes to adult health. Health disparities are present in ethnic minority children and are associated with physical inactivity. This study aims to examine the immediate and sustained effects of the Children’s Health Activity Motor Program (CHAMP) - Afterschool Program (ASP), delivered by staff, on physical activity, motor performance, perceived motor competence, health-related physical fitness, and weight status. By training existing ASP staff, the long-term goal is to provide a sustainable, ecologically-relevant, and evidence-based program during the early elementary years that is health-enhancing and contributes to lifelong physical activity in the ethnic minority population.

PI_NAMEs: PFEIFFER, KARIN A;ROBINSON, LEAH ELIZABETH (contact)

PROGRAM_OFFICER_NAME: LONG, SYLVIA ELISABETH

PROJECT_TERMS: Address;Adolescence;Adult;after-school program;Age;American;Area;Behavior;Body fat;Body mass index;cardiorespiratory fitness;Child;Child Health;Childhood;Cluster randomized trial;Communities;comparison control;Competence;Data;design;Development;Dose;ethnic minority;ethnic minority population;Evidence based intervention;Evidence based program;exercise intervention;Exhibits;fitness;follow-up;Funding;Future;girls;Goals;Guidelines;Health;health disparity;Health Promotion;healthy weight;high risk;improved;innovation;Intervention;intervention effect;Intervention Studies;Knowledge;Learning;Link;Literature;Long-Term Effects;Maintenance;Mediating;Michigan;minority children;Minority Groups;moderate-to-vigorous physical activity;Motor;Motor Activity;motor skill learning;Motor Skills;Movement;Muscle;Outcome;Performance;Physical activity;physical conditioning;Physical Education;Physical Fitness;physical inactivity;post intervention;primary outcome;Program Development;programs;Randomized;Randomized, Controlled Trials;Research;school environment;Schools;skill acquisition;Testing;therapy design;Time;Training;United States National Institutes of Health;Weight;Work;Youth

PROJECT_TITLE: The CHAMP Afterschool Program: Promoting Physical Activity & Health in Children

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Mental Health;Neurosciences;Pediatric;Pregnancy;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PUBLIC HEALTH RELEVANCE Many developmental and psychiatric disorders likely originate during prenatal development. This work will lay critical foundations for understanding interactions between prenatal inflammation and human neural development, beginning in utero. We aim to achieve better mechanistic understanding of candidate disease pathways and to identify postnatal environmental modifiers, rendering new opportunities for early detection, prevention, and treatment of disease.

PI_NAMEs: THOMASON, MORIAH E (contact);TRENTACOSTA, CHRISTOPHER J

PROGRAM_OFFICER_NAME: KING, ERIN MICHELE

PROJECT_TERMS: Address;Adolescent;Affect;Age;Anatomy;Animals;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior;Behavioral;behavioral outcome;Belief;Biological;Biological Assay;Biological Markers;Birth;Brain;C-reactive protein;Child;Child Rearing;Childhood;cognitive development;cohort;Conceptions;connectome;contextual factors;course development;Data;Data Collection;deciduous tooth;Dependence;Development;developmental disease;Diffusion Magnetic Resonance Imaging;Disease;Disease Pathway;Early Diagnosis;Enrollment;Environment;Etiology;Event;fetal;Fetal Development;Fetal Neurobehavioral Development;Foundations;Functional Magnetic Resonance Imaging;Future;Health;Human;imaging study;Immune;immune activation;Impairment;in utero;indexing;Inflammation;Inflammatory;inflammatory marker;innovation;interest;Interleukin-1;Intervention;intrauterine environment;intrauterine inflammation;Lead;Life;Link;Long-Term Effects;Longitudinal cohort;Magnetic Resonance Imaging;Measures;Mental disorders;Modeling;Mothers;Neighborhoods;Nervous System Disorder;neural;neural circuit;neural correlate;neurobehavioral;Neurocognitive;neurodevelopment;Neurodevelopmental Disorder;neuroimaging;Neurologic;Neurological outcome;offspring;Outcome;Participant;Pathologist;Pathway interactions;Placenta;postnatal;Pregnancy;prenatal;Prevention;Property;protective factors;Protocols documentation;psychologic;public health relevance;Research;resilience;resilience factor;response;Rest;Risk;Sampling;Schizophrenia;sleep behavior;social;Stress;Sum;Support System;System;systemic inflammatory response;Techniques;temporal measurement;Testing;Third Pregnancy Trimester;Time;TNF gene;Tooth structure;Trauma;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Examining Prenatal Inflammation and Neurodevelopment in a Longitudinal Fetal-to-Age 9 Imaging Study

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: The overall goal of this multi-site study is to refine a consensus protocol for imaging brain tumor perfusion and validate its clinical utility and value in patients with tumors. Such validation will help to promote widespread adoption of the consensus protocol and improve the management of patients with brain tumors.

PI_NAMEs: BOXERMAN, JERROLD L;HU, LELAND ;QUARLES, CHRISTOPHER CHAD (contact);SCHMAINDA, KATHLEEN MARIE

PROGRAM_OFFICER_NAME: ZHANG, HUIMING

PROJECT_TERMS: 19q;Acceleration;Address;Admixture;Adoption;Aftercare;Benchmarking;Biopsy;Brain Neoplasms;brain tumor imaging;cerebral blood volume;Classification;Clinical;clinical application;clinical decision-making;clinical practice;Clinical Trials;cohort;Committee Members;Consensus;Data;digital;drug development;Europe;Excision;Functional Imaging;Future;Glioma;Goals;Guidelines;Healthcare;Histologic;Image;Imaging Techniques;improved;in silico;in vivo;Institution;International;longitudinal analysis;Magnetic Resonance Imaging;Maps;Measures;Meta-Analysis;Methodology;Methods;Multi-Institutional Clinical Trial;Mutation;neuro-oncology;Patient Care Management;Patients;Perfusion;Phase;Positioning Attribute;Prediction of Response to Therapy;Predisposition;prospective;Protocols documentation;Publications;Publishing;Quality Control;radiation effect;Radiation necrosis;Recommendation;Recurrence;Recurrent tumor;Repeat Surgery;Reporting;Reproducibility;Research Personnel;Scanning;serial imaging;Site;Societies;standard of care;Standardization;targeted treatment;Tissue imaging;tool;Translations;treatment effect;tumor;tumor diagnosis;tumor heterogeneity;Update;Validation

PROJECT_TITLE: Establishing the clinical utility of a consensus DSC-MRI Protocol


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Diabetes;Kidney Disease;Precision Medicine;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE MCD, FSGS, MN, and IgAN are rare glomerular diseases that cause significant individual and societal morbidity. Diabetes mellitus is a common comorbidity of these glomerular diseases and may alter their diagnosis, treatment and long-term outcomes. CureGN-Diabetes is a longitudinal, observational ancillary study to CureGN (which does not include patients with diabetes), aimed at understanding and ameliorating the impact of diabetes on patients with glomerular diseases.

PI_NAMEs: BOMBACK, ANDREW STEPHEN;COPPOCK, GAIA MUALLEM;MOTTL, AMY  (contact);NAST, CYNTHIA C.

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: Address;Adult;Affect;Ancillary Study;Area;biobank;Biological Markers;Biopsy;Calcineurin inhibitor;Cardiovascular Diseases;Cardiovascular system;Caring;Categories;Characteristics;Chronic Kidney Failure;Clinical;Clinical Data;clinical research site;cohort;Collection;comorbidity;Complex;cost;Data;Data Collection;data harmonization;Diabetes Mellitus;diabetic;Diabetic Nephropathy;Diagnosis;diagnostic value;Disease;disease diagnosis;disease heterogeneity;Enrollment;Epidemiology;Exclusion;Focal and Segmental Glomerulosclerosis;follow-up;Foot Process;Funding;Future;Healthcare;Histologic;Histopathology;Hospitalization;IGA Glomerulonephritis;Immune System Diseases;immunomodulatory therapies;Immunosuppression;improved;Individual;individual patient;Infection;infection risk;Infrastructure;Kidney;kidney biopsy;Knowledge;Lesion;Lesion by Morphology;Letters;Literature;Longitudinal cohort;Longitudinal Studies;Longitudinal, observational study;Mediating;Membranous Glomerulonephritis;Minority;Morbidity - disease rate;Morphology;Movement;multi-ethnic;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;Nodular glomerulosclerosis;Outcome;Parents;Pathologic;Pathology;Pathway interactions;Patient Care;Patient-Focused Outcomes;Patients;Pattern;personalized care;Persons;Population;precision medicine;predict clinical outcome;primary outcome;Productivity;prognostic value;prospective;Protocols documentation;Quality of life;recruit;Renal glomerular disease;Research;Research Personnel;Resources;Risk;Sclerosis;Severities;Site;Specificity;Standardization;Steroids;Time;Tissues;tool;treatment risk;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: The Impact of Diabetes on Patients with Glomerular Disease: CureGN-Diabetes

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_NAME: WHITMAN-WALKER INSTITUTE, INC.

ORG_STATE: DC

PHR: Project Narrative Gay, bisexual, and other sexual minority men (SMM), who are at disproportionately high risk for HIV infection, are also less likely to achieve viral load (VL) suppression compared to other groups. Research is needed to identify preventable structural, psychosocial, and behavioral factors that influence VL suppression for the purposes of developing effective early intervention strategies. Moreover, the successful implementation of TasP and U=U messaging is a necessary component of the strategy to end the HIV epidemic, but rigorous research is needed to inform its successful implementation. We aim to address these issues with two studies grounded in the Social Ecological Model (SEM) to simultaneously examine both VL suppression and implementation barriers surrounding U=U from multiple levels of influence. Study 1 will involve longitudinally following 250 newly diagnosed SMM, capitalizing on an existing cohort tracking HIV seroconversion, to examine predictors of durable VL suppression as well as any potential risks associated with implementing U=U. In Study 2, we will use focus groups conducted three times over five years to inform implementation of U=U messaging.

PI_NAMEs: RENDINA, H. JONATHON  (contact);TALAN, ALI

PROGRAM_OFFICER_NAME: SHARP, GERALD B

PROJECT_TERMS: Address;Adherence;Advocacy;AIDS prevention;American;antiretroviral therapy;Back;Behavioral;Binding;Biological;Bisexual;Blood;care providers;Caring;Clinical;Clinical Trials;cohort;Compensation;Consensus;Continuity of Patient Care;Couples;critical period;Data Reporting;design;Diagnosis;Drops;Dryness;Early Intervention;efficacy validation;Empirical Research;Enrollment;Epidemic;Epidemiology;Event;Focus Groups;Future;Gays;General Population;Goals;Guidelines;Health;Health Personnel;high risk;HIV;HIV diagnosis;HIV Infections;HIV Seronegativity;HIV Seropositivity;Home;implementation barriers;improved;improved outcome;indexing;Individual;Infection;insight;Intervention;Interview;Link;Location;men;men who have sex with men;Methods;minority stress;Modeling;Monitor;Morbidity - disease rate;mortality;Movement;National Institute of Allergy and Infectious Disease;National Institute of Child Health and Human Development;National Institute of Mental Health;Nature;Newly Diagnosed;Outcome;Patient Self-Report;Pattern;Persons;Phase;Population;Provider;psychosocial;Public Health;Qualitative Methods;recruit;Research;resilience;resilience factor;Resistance;Risk;Risk Factors;Risk Reduction;routine practice;Safety;Sampling;scale up;seroconversion;Sex Behavior;sexual HIV transmission;sexual minority health;sexual minority men;social;Spottings;Study models;success;surveillance data;Surveys;theories;therapy adherence;therapy development;Time;timeline;Translating;transmission process;treatment as prevention;Treatment Efficacy;United States National Institutes of Health;uptake;Viral;Viral Load result;virtual

PROJECT_TITLE: Understanding Viral Suppression for Newly Diagnosed HIV+ Men to Inform Implementation of TasP and U=U

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Data Science;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research

ORG_NAME: UNIVERSITY OF UTAH

PHR: PROJECT NARRATIVE Efforts to improve public health communication about colorectal cancer (CRC) and CRC screening (CRCS) require understanding what information is commonly seen by target audiences and consideration of existing information and behavior disparities for populations at higher risk for CRC (e.g., Black Americans). The current project uses novel computational approaches to monitor the public communication environment about CRCS, crowdsourcing to engage in formative evaluation of possible message content, and a randomized, controlled trial to validate these computational and crowdsourcing approaches. The project tests novel approaches to monitor and evaluate public health information to inform health communication research and practice.

PI_NAMEs: KING, ANDY J (contact)

PROGRAM_OFFICER_NAME: CHOU, WEN-YING

PROJECT_TERMS: Address;Adopted;Adult;Affect;Age;Age Years;Alcohols;Behavior;Belief;Black American;Cancer Control;Categories;caucasian American;Code;colon cancer screening;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;colorectal cancer screening;Communication;Communication Research;crowdsourcing;Data;Data Collection;Death Rate;design;Diagnosis;digital media;Disease;Disparity;Disparity population;Early Diagnosis;efficacy trial;Environment;Evaluation;evidence base;experimental study;Exposure to;formative assessment;Future;Goals;Guidelines;Health;health communication;Health Policy;Health Promotion;high risk;Human;improved;Incidence;Individual;Inequality;Information and Media;innovation;Knowledge;Light;Malignant Neoplasms;men;Methods;Misinformation;Monitor;Natural Language Processing;Not Hispanic or Latino;novel;novel strategies;Perception;Persons;Persuasive Communication;Population;Population Heterogeneity;Populations at Risk;preference;Prevention;Procedures;Public Health;Public Opinion;Race;racial population;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Research;Research Personnel;Respondent;Risk;Sampling;Scanning;screening;screening guidelines;social media;Social Network;Source;Survey Methodology;Surveys;Techniques;Technology;Testing;Tobacco;United States;wiki;Woman

PROJECT_TITLE: Using Natural Language Processing and Crowdsourcing to Monitor and Evaluate Public Information and Communication Disparities about Colon Cancer Screening

STUDY_SECTION: BCHI

STUDY_SECTION_NAME: Biomedical Computing and Health Informatics Study Section[BCHI]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biotechnology;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Genetics;Human Genome;Precision Medicine;Substance Misuse

ORG_DEPT: GENETICS

PHR: Project Narrative Drug and alcohol dependence are heritable disorders that represent leading causes of morbidity and mortality worldwide. This project will elucidate how genes implicated in GWAS affect addiction by identifying multiple carriers of very rare, functional variants within them and intensively investigating their effects via deep phenotyping. We will identify novel rare variants that underlie the pathophysiology of addiction and have clinical translational potential by leveraging addiction genetic association consortia, publicly available whole genome sequence datasets, large medical biobank repositories, and follow-up of high impact rare variants in extended carrier pedigrees.

PI_NAMEs: ALBERT, FRANK WOLFGANG;VRIEZE, SCOTT IAN (contact)

PROGRAM_OFFICER_NAME: POLLOCK, JONATHAN D

PROJECT_TERMS: Acceleration;addiction;Affect;Alcohol consumption;Alcohol dependence;Alleles;Behavior;Behavioral;biobank;bioinformatics tool;Biological;case control;Cell Line;clinical translation;Communities;Complementary DNA;Complex;Consent;cost;cost effective;CRISPR/Cas technology;Data;Data Set;deep sequencing;Dependence;design;Development;Disease;dosage;Drug Addiction;drug development;Drug usage;Epigenetic Process;ethnic diversity;Etiology;experimental study;Extended Family;Family;Family member;follow-up;Functional disorder;Genes;Genetic;genetic association;genetic pedigree;genetic resource;genetic variant;genome sequencing;genome wide association study;genome-wide;genomic locus;Genomics;Genotype;Haplotypes;Hereditary Disease;Heritability;Human;Human Biology;improved;Individual;Induced Mutation;insight;interest;Intervention Studies;Investigation;Link;Measurement;Medical;Meta-Analysis;Michigan;Molecular;Morbidity - disease rate;mortality;multidisciplinary;Neurocognitive;nicotine use;novel;novel strategies;Participant;Phenotype;Price;Procedures;psychosocial;rare variant;Recontacts;Recording of previous events;recruit;Reporting;repository;research and development;Research Personnel;Risk;Sampling;Smoking;Substance Addiction;substance use;Technology;Testing;therapeutic target;Time;Tobacco use;trait;Trans-Omics for Precision Medicine;Translating;translational potential;Translational Research;United States National Institutes of Health;Validation;Variant;variant detection;whole genome

PROJECT_TITLE: Deep Sequencing, Phenotyping, and Imputation in Large-Scale Biobanks: A Novel and Cost-Effective Framework to Identify Rare Mutations Associated with Addiction

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Cost Effectiveness Research;Dissemination and Implementation Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: SEATTLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Tuberculosis (TB) is the leading cause of mortality in people with HIV in sub-Saharan Africa, due partly to substantial delays in diagnosis caused by a lack of adequate clinic-based TB testing. The proposed research will evaluate a set of novel, point-of-care, rapid urine-based tests for TB in HIV-infected persons in an ambulatory clinical setting in South Africa, use results to develop improved diagnostic testing algorithms, and estimate the potential impact of introducing new diagnostic tests in different representative clinical use scenarios. The results of this study will inform TB diagnostic approaches for clinicians in high TB/HIV-burden settings, and will provide a framework to guide policymakers in comparing and adopting emerging diagnostic tests to reduce the burden of HIV-associated TB.

PI_NAMEs: SHAPIRO, ADRIENNE E (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: Adopted;Adult;Africa;Africa South of the Sahara;Algorithms;Biological Assay;Body mass index;budget impact;care seeking;career;Caring;CD4 Lymphocyte Count;Classification;Clinic;Clinical;Clinical Research;clinically relevant;cohort;Collaborations;Consumption;Cost Analysis;Data;Decision Analysis;Detection;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic algorithm;diagnostic strategy;Diagnostic tests;economic evaluation;effective intervention;Epidemiologic Methods;Epidemiology;epidemiology study;Equipment;Evaluation;evaluation/testing;follow-up;Foundations;Generations;Goals;Health;health economics;HIV;HIV/TB;Hospitalization;Hospitals;Impact evaluation;implementation science;implementation strategy;improved;In Vitro;incremental cost;infectious disease model;innovation;Inpatients;Laboratories;lipoarabinomannan;meetings;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;microcosting;minimal risk;Modeling;Morbidity - disease rate;mortality;mycobacterial;next generation;novel;novel diagnostics;Outpatients;Patient Dropouts;Patient Selection;Patients;Performance;Peripheral;Persons;Physicians;point of care;point of care testing;Policy Maker;Population;Positioning Attribute;predictive modeling;primary outcome;Property;prospective;Randomized, Controlled Trials;regression trees;Research;Research Institute;Resource-limited setting;rural health clinic;rural South Africa;Science;Scientist;screening;secondary outcome;Services;skills;South Africa;Specificity;Specimen;Sputum;standard of care;Symptoms;Testing;Time;tool;Training;Training Programs;Translating;transmission process;Tuberculosis;Tuberculosis diagnosis;tuberculosis diagnostics;tuberculosis treatment;uptake;Urine;Validation;validation studies;World Health Organization

PROJECT_TITLE: Novel clinic-based TB diagnostics and testing algorithms for persons with HIV

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS(AI)]


ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: Veterans have higher rates of smoking and exposure to inhaled toxins. Veterans also have higher rates of chronic lung diseases, such as asthma, chronic obstructive pulmonary disease (COPD), and interstitial lung disease. However, the risk for developing lung disease is different for every person. Genetic studies may help to us understand risk among Veterans. Genetic studies require large numbers of people with and without chronic lung disease – this has been challenging because tests for diagnosing lung diseases are not always performed, or the information is hard to retrieve. In this project, we use advanced technologies to gather information from the VA’s electronic medical records and new computer programs to analyze chest CAT scans to identify Veterans with and without lung disease. We will then identify differences is genetic markers between Veterans with and without lung disease in the Million Veteran Program. Findings from this study will help us understand risk and develop personalized treatments in the future.

PI_NAMEs: WAN, EMILY S (contact)

PROJECT_TERMS: 3-Dimensional;Address;adjudication;Adult;Algorithms;Archives;Asthma;biobank;blood-based biomarker;case control;Cause of Death;Chest;chest computed tomography;Chest imaging;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Clinical;cohort;Collaborations;computer program;Computer software;Computerized Medical Record;Data;Development;Diagnosis;Diagnostic tests;disability;Disease;disease diagnosis;Disease Management;disease phenotype;Disease susceptibility;Electronic Health Record;electronic structure;Elements;Enrollment;Environment;environmental enrichment for laboratory animals;Environmental Exposure;epidemiologic data;Epidemiology;epidemiology study;ethnic diversity;Exposure to;Fibrosis;firewall;Foundations;Funding;Future;gene environment interaction;General Population;Genes;Genetic Diseases;genetic epidemiology;Genetic Markers;Genetic study;genetic variant;genome wide association study;Genomics;Health;health care service utilization;Heterogeneity;idiopathic pulmonary fibrosis;Image;imaging modality;imaging platform;Individual;information gathering;Inhalation;International;International Classification of Disease Codes;interstitial;Interstitial Lung Diseases;Investigation;Knowledge;Lung;Lung Diseases;Manuals;Measurement;Medical Imaging;Methods;military veteran;Modernization;mortality;multi-ethnic;multimodality;Natural Language Processing;novel;Outcome;participant enrollment;Pathogenesis;Pathologic;Patient Self-Report;personalized medicine;Persons;Pharmacogenomics;pharmacologic;Phenotype;phenotyping algorithm;polygenic risk score;Population Heterogeneity;Probability;programs;prospective;prototype;Pulmonary Emphysema;quantitative imaging;radiological imaging;radiologist;Reporting;Research;Research Personnel;Resolution;respiratory;Retrieval;Risk;risk stratification;risk variant;Secure;Smoking;Smoking Status;Spirometry;Subgroup;System;Technology;Test Result;Testing;tool;Toxic Environmental Substances;Toxin;United States;Validation;Veterans;Veterans Health Administration;Visual;Work;X-Ray Computed Tomography

PROJECT_TITLE: Chronic lung disease phenotyping and genomics in the Veterans Health Administration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 PULM-N (01)]


ORG_CITY: SAN FRANCISCO

ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

ORG_STATE: CA

PHR: Muscle degeneration, characterized by progressive deposition of extracellular matrix (ECM) proteins and adipocytes (fibro-fatty degeneration) is a central finding in many musculoskeletal disease processes and is associated with a shortened lifespan. Fibroadipoprogenitor cells (FAPs) have been found to be the central regulator of fibro-fatty degeneration, but we have shown that given the proper stimulus (B-agonist pharmacologic treatment, blood flow restriction), they are able to differentiate into a pro-myogenic beige fat state that stimulates muscle regeneration. In this study, we will evaluate the mechanisms of beige-FAP mediated muscle regeneration, focusing on mitochondrial transfer as a novel means by which FAPs can stimulate muscle regeneration and improve outcomes in several musculoskeletal conditions that affect the aging VA population.

PI_NAMEs: FEELEY, BRIAN  (contact)

PROJECT_TERMS: Address;Adipocytes;Adipose tissue;Affect;age related;Aging;Agonist;Amyotrophic Lateral Sclerosis;Bioenergetics;Biogenesis;Blood flow;Cancer Cachexia;Cell Differentiation process;Cell fusion;cell injury;Cell Proliferation;Cells;Chronic Disease;Clinical;clinical prognostic;clinically relevant;Data;Deposition;Development;Disease;Extracellular Matrix Proteins;Fatty acid glycerol esters;FDA approved;Fibroblasts;Fibrosis;Homeostasis;Hypoxia;improved;improved outcome;In Vitro;in vitro regeneration;in vivo;in vivo regeneration;Infiltration;Injury;injury and repair;Intramuscular;Ischemia;Ischemic Preconditioning;Knowledge;life span;Mediating;Mesenchymal Stem Cells;Mitochondria;Modeling;mouse model;Muscle;Muscle Cells;muscle degeneration;Muscle function;muscle progenitor cell;muscle regeneration;Muscle satellite cell;Musculoskeletal;Musculoskeletal Diseases;musculoskeletal injury;myogenesis;Nanotubes;Natural regeneration;Nervous System Disorder;novel;Orthopedics;patient population;Patients;pharmacologic;Pharmacological Treatment;Phenotype;Play;Population;preconditioning;prevent;Process;progenitor;Prognostic Factor;Property;Proteins;Quality of life;rational design;Recovery;regenerative;Reperfusion Injury;Reperfusion Therapy;response;rho GTP-Binding Proteins;Role;Rotator Cuff;rotator cuff tear;Skeletal Muscle;stem cell proliferation;stem cells;Stimulus;Systemic disease;Therapeutic;therapeutic target;tissue injury;Tissue Transplantation;Tissues;treatment strategy;uncoupling protein 1;Up-Regulation;Vertebral column;Work

PROJECT_TITLE: Mitochondrial biogenesis and transfer to promote muscle regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 SURG-P (01)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: Project Narrative Glaucoma is a leading cause of irreversible blindness. Current therapies for control of intraocular pressure include surgery and medications that are effective but are imperfect because of regression, side effects, and patient non-compliance. The proposed studies will unveil the cellular and molecular mechanisms of trabecular meshwork regeneration by stem cells, which will lead to stem cell-based therapies for controlling intraocular pressure and preventing glaucomatous vision loss.

PI_NAMEs: DU, YIQIN  (contact)

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: Address;adipose derived stem cell;aged;Aging;aqueous;Aqueous Humor;awake;Blindness;Cell Physiology;Cell Survival;Cells;Cellularity;chemokine;Clinical;clinical application;clinical translation;Cornea;CRISPR/Cas technology;CXCR4 gene;Data;Deposition;design;Dexamethasone;Dinoprostone;effective therapy;endogenous stem cells;Engraftment;experimental study;Extracellular Matrix;Foundations;Funding;Glaucoma;Goals;Home;Homeostasis;Homing;Human;Impairment;In Vitro;in vivo;in vivo Model;inhibitor;Injections;Integrin alpha5beta1;laser photocoagulation;Lead;life span;Matrix Metalloproteinases;migration;Modeling;Molecular;mouse genetics;Mus;mutant;Mutation;myocilin;Natural regeneration;nerve damage;Operative Surgical Procedures;Optic Nerve;Pathologic;Pathway interactions;Patient Noncompliance;Pattern;Pharmaceutical Preparations;Phenotype;Physiologic Intraocular Pressure;preservation;prevent;PTGS2 gene;regeneration potential;Rejuvenation;repaired;Resistance;restoration;Retinal Ganglion Cells;Risk Factors;self-renewal;side effect;Site;Solid;Source;SOX21 gene;stem cell proliferation;stem cell self renewal;stem cell therapy;Stem cell transplant;stem cells;stemness;Stromal Cell-Derived Factor 1;stromal progenitor;Testing;Therapeutic;Tissues;Trabecular meshwork structure;transcriptome sequencing;Transgenes;Transplantation;Treatment Efficacy;WNT Signaling Pathway;Work

PROJECT_TITLE: Mechanisms of Trabecular Meshwork Regeneration by Stem Cells

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Mental Health;Mental Illness;Pediatric;Prevention;Serious Mental Illness;Social Determinants of Health;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Maternal depression disproportionately affects low-income and minority women and has negative impacts on their children. In the present proposal, we aim to improve outcomes for Head Start children by deploying a stepped-care intervention, in which mothers with low level depressive symptoms are offered a prevention program based on the Problem Solving Education model, and mothers with greater symptoms are offered Engagement Sessions to link them with formal mental health services. We propose to test the efficacy of this model among both mothers and children, and determine mechanisms of action by which improved maternal wellbeing promotes child resiliency.

PI_NAMEs: FEINBERG, EMILY ;SILVERSTEIN, MICHAEL  (contact)

PROJECT_TERMS: Absenteeism;Academic achievement;Academy;Adaptive Behaviors;Address;Adherence;Affect;Affective;Area;arm;Award;Behavior;Behavioral;Caring;Child;Child Rearing;Cognitive;Communities;community intervention;Conflict (Psychology);coping;Depressed mood;depressive symptoms;design;Development;Education;Educational Models;effectiveness study;effectiveness trial;efficacy testing;efficacy trial;Employee;Environmental Risk Factor;experience;Face;Family;Feasibility Studies;Funding;Goals;Head Start Program;improved;improved outcome;Intervention;intervention delivery;intervention effect;Link;Low income;lower income families;Massachusetts;maternal depression;maternal outcome;maternal wellbeing;Measures;Medicine;Mental Depression;Mental Health;Mental Health Services;Minority Women;Modeling;Mother-Child Relations;Mothers;multi-component intervention;National Institute of Child Health and Human Development;Nursery Schools;Outcome;Parents;Pattern;perceived stress;Pilot Projects;pilot trial;Population;population based;prevent;Prevention;Prevention program;Prevention strategy;Problem Solving;Process;programs;Protocols documentation;Provider;Public Health;Publishing;Randomized;randomized trial;Readiness;Reduce health disparities;reduce symptoms;Reporting;Research;Research Priority;resilience;Risk;Sampling;Schools;Series;Services;Site;skills;social;social factors;social skills;Social Work;stress management;symptomatology;Symptoms;Testing;theories;United States National Institutes of Health

PROJECT_TITLE: Improving Preschool Outcomes by Addressing Maternal Depression in Head Start

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


FUNDING_MECHANISM: OTHERS

ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

ORG_STATE: CO

PHR: Inflammatory bowel disease (IBD) is a chronic, idiopathic condition characterized by relapsing and debilitating intestinal inflammation. IBD represents a disease with among the highest hospitalization rates within military veteran populations (>100,000 hospitalizations from 1975-2006), showing high readmission rates with incidences on the increase in some populations. A recent study of more than 100,000 military service members estimated the incidence of IBD to be 2-10 times greater than non-service members, with a striking relationship between IBD incidence and the number of life stressors. We found that the protein HIF (hypoxia-inducible factor), previously shown to be important for intestinal health, is responsible for guiding expression of autophagy, a molecular pathway essential for gut stability that also influences interactions between gut cells and resident bacteria. We hypothesize that HIF-driven autophagy regulates interactions between the intestine and gut bacteria, shaping the GI environment to influence IBD pathogenesis.

PI_NAMEs: DOWDELL, ALEXANDER SHEA (contact)

PROJECT_TERMS: Animal Model;antimicrobial;Autophagocytosis;Bacteria;Bacterial Translocation;Binding;Binding Sites;Biology;Cells;Chemicals;ChIP-on-chip;Chronic;cohort;Colitis;Complement;Data;Defect;Dependence;Development;Disease;Disease susceptibility;Effectiveness;Environment;Epithelial Cells;Epithelium;Etiology;Family;Functional disorder;Funding;Future;gain of function;Gastrointestinal tract structure;Gene Expression Regulation;Genes;Genetic;Genetic Polymorphism;Genetic Transcription;genome wide association study;Goals;gut bacteria;gut inflammation;Health;Hospitalization;hospitalization rates;host-microbe interactions;Hypoxia;Hypoxia Inducible Factor;Immunosuppression;Impairment;improved;In Vitro;in vivo;Incidence;Incidence Study;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;insight;intestinal epithelium;intestinal homeostasis;Intestinal Mucosa;Intestines;knock-down;Life;Link;loss of function;Lysosomes;Mediating;Mentors;Mentorship;Metabolic;microbial;microbiota;microorganism interaction;military service;military veteran;Modeling;Molecular;Mucositis;murine colitis;Mus;mutant;normoxia;novel therapeutics;Oxygen;Pathogenesis;Pathway interactions;Patients;Persons;pharmacologic;Population;Positioning Attribute;Predisposition;promoter;Promoter Regions;Protein Isoforms;Proteins;prototype;readmission rates;Recurrence;Recycling;Regulation;Relapse;Research;Research Personnel;response;Risk Factors;Role;Salmonella typhimurium;service member;Shapes;side effect;Specificity;Stabilizing Agents;stressor;Supplementation;symposium;symptom management;System;Testing;therapeutic development;Time;Training;transcription factor;Veterans;Work

PROJECT_TITLE: HIF-Regulated Autophagy in Host-microbe Interactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 GAST-L (01)]


ORG_CITY: BIRMINGHAM

ORG_NAME: BIRMINGHAM VA MEDICAL CENTER

ORG_STATE: AL

PHR: Project Narrative The pathogenesis of pancreatic cancer (PDAC) is incompletely understood. Our recent work has demonstrated that gut microbiome modulates adaptive immune response and promotes PDAC growth and metastases. Intriguingly, our preliminary data in animal models suggest that gut microbiome is critical for the smoking induced tumor initiation and progression as well. Our data also suggest that smoking induced dysbiosis attenuates anti- cancer immune response. The current proposal is the clinical investigation of the findings generated from the pre-clinical models and included a combination of a clinical, observational, non-interventional study in humans and translational studies generated using the samples collected from humans. The proposed study will uncover new molecular pathways of PDAC growth in smokers, which can be translated into the clinical paradigm for management of these patients

PI_NAMEs: DUDEJA, VIKAS  (contact)

PROJECT_TERMS: adaptive immune response;Affect;Alcohol consumption;Animal Model;anti-cancer;Antibiotics;Attenuated;Cancer Etiology;cancer initiation;cigarette smoking;Clinical;clinical investigation;Clinical Research;cytokine;Data;Development;Diet;Disease;dysbiosis;effective therapy;Etiology;Evaluation;Feces;former smoker;Future;Genetically Engineered Mouse;Germ-Free;Growth;gut metagenome;gut microbiome;healthy volunteer;Human;Immune;Immune response;Incidence;insight;KRASG12D;Life Style;lifestyle factors;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Mediating;metabolome;metabolomics;metagenome;Metagenomics;microbial;microbial colonization;microbiome composition;Military Personnel;military veteran;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Neoplasm Metastasis;non-smoker;novel;novel therapeutic intervention;Obesity;Outcome;pancreas development;pancreatic cancer model;pancreatic cancer patients;Pathogenesis;Pathway interactions;Patients;Pre-Clinical Model;PTGS2 gene;Risk Reduction;Role;Sampling;Shotguns;Signal Transduction;single-cell RNA sequencing;Smoker;Smoking;Source;stool sample;Testing;Therapeutic;Tobacco;Tobacco use;Translating;translational study;Transplantation;treatment strategy;tumor initiation;tumor progression;Tumor Promotion;Tumor-infiltrating immune cells;tumorigenic;Veterans;Work

PROJECT_TITLE: Role of Gut Microbiome in Smoking Induced Promotion of Pancreatic Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 ONCC-S (01)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases;Microbiome;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Narrative This project investigates how the gut microbiota communicates with the bone marrow to alter gut inflammation and protect from infection with enteric pathogens. Understanding the mechanisms of this process will inform future studies in the development of treatments for both infectious and inflammatory diseases.

PI_NAMEs: BURGESS, STACEY L (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Adoptive Transfer;Amebiasis;Amebic colitis;Amoeba genus;Antigens;Antiparasitic Agents;Bacteria;Bile Acids;bile salts;Bioinformatics;Biological Assay;Biology;Bone Marrow;Chemicals;Child;Cholates;chromatin immunoprecipitation;Clostridium;Colitis;Communicable Diseases;Communication;Data;Dedications;dehydroxylation;deoxycholate;Deoxycholic Acid;Development;Diarrhea;Disease;Educational process of instructing;Entamoeba;Entamoeba histolytica;enteric pathogen;Epigenetic Process;Exposure to;Future;Gene Expression;granulocyte;granulocyte-monocyte progenitors;Granulopoiesis;gut colonization;gut inflammation;gut microbiome;gut microbiota;Hematopoiesis;host microbiota;Immune system;Immunity;Immunologic Memory;In Vitro;Infant;Infection;Infectious colitis;Inflammation;Inflammatory;innovation;Intestines;Knockout Mice;Letters;low income country;Marrow;Measures;Mediating;Mediator;Metabolic;microbial;microbiome;microbiome research;microbiota;Modeling;Monoclonal Antibodies;monocyte;Mucous Membrane;Mus;Natural Immunity;neutrophil;next generation;next generation sequencing;novel;novel strategies;pathogen;Pathogenesis;Pathway interactions;Phenotype;Population;Predisposition;prevent;Process;Production;professional atmosphere;progenitor;receptor;Research;response;Serum;Severities;Signal Transduction;stem cell expansion;stem cell population;Testing;therapy development;trafficking;Training;transcriptome sequencing;translational medicine;Vaccines;whole genome;Work

PROJECT_TITLE: Gut microbiome communication with the bone marrow regulates intestinal inflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-M(02)M]


ORG_CITY: RICHMOND

ORG_NAME: VA VETERANS ADMINISTRATION HOSPITAL

PHR: Cancer is the second leading cause of death among US veterans, and lung cancer is associated with the greatest mortality in these patients. Non-small cell lung cancers (NSCLC) represent the majority of lung cancers and carry a poor prognosis with a median survival of less than 12 months. Most patients present with unresectable disease, and current treatment options of chemotherapy and radiation are palliative at best. Our laboratory has identified key mechanisms specific to a particular mutation/activation of an oncogene in NSCLCs, which are plausible and highly desired targets for the development of new and targeted anti-cancer therapeutics (precision medicine). This project, project#1, of a collaborative application explores these cellular mechanisms in depth with the goal of developing new therapeutics to combat NSCLC, and thereby, aid US Veterans.

PI_NAMEs: CHALFANT, CHARLES E. (contact)

PROJECT_TERMS: Ablation;Anabolism;anti-cancer therapeutic;Apoptosis;cancer cell;Cancer Etiology;Cancer Model;cancer stem cell;Cause of Death;cDNA Expression;Cell Lineage;Cell Survival;cell transformation;Cells;ceramide 1-phosphate;ceramide kinase;Cessation of life;Chemotherapy and/or radiation;Collaborations;combat;Coupled;CRISPR/Cas technology;Data;Development;Disease;Foundations;Generations;Genes;Genetic;Genetically Engineered Mouse;Glucosylceramides;Goals;Grant;Growth;Homeostasis;Human;improved;Individual;innovation;K-ras mouse model;KRAS oncogenesis;KRAS2 gene;Laboratories;Lactosylceramides;Lentivirus;Link;Lung Adenocarcinoma;lung cancer cell;lung tumorigenesis;Maintenance;Malignant neoplasm of lung;Malignant Neoplasms;MEKs;Membrane Potentials;Metabolism;Mitochondria;mitochondrial membrane;Modality;Molecular;mortality;Mus;mutant;Mutate;Mutation;Non-Small-Cell Lung Carcinoma;novel;novel therapeutic intervention;novel therapeutics;Oncogene Activation;Oncogenes;Organelles;palliative;Pathway interactions;Patient-Focused Outcomes;Patients;Phosphorylation;Precision cancer therapy;precision medicine;Process;Prognosis;Proto-Oncogene Proteins c-akt;Role;Signal Pathway;Signal Transduction;Site-Directed Mutagenesis;small hairpin RNA;Small Interfering RNA;small molecule inhibitor;Sphingolipids;standard of care;stem cells;Survival Rate;Therapeutic;therapeutic target;therapy outcome;tool;translation to humans;Tubulin Interaction;tumor;tumorigenesis;tumorigenic;Tumorigenicity;Unresectable;Validation;VDAC1 gene;Veterans

PROJECT_TITLE: BCCMA: The Role of Sphingolipids in the Induction & Maintenance of Non-Small Cell Lung Cancer by Oncogenic KRAS

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 ONCB-A (01)]


ORG_CITY: BOSTON

ORG_STATE: MA

PHR: Triple-negative breast cancer (TNBC) is a highly malignant breast cancer type that afflicts women veterans and possesses no effective or targeted therapies. Better understanding of how TNBC develops and progresses will lead to cures that save veteran lives. Using a recently developed TNBC model, we identified a novel molecular pathway that regulates the generation, propagation, and maintenance of so-called `cancer stem cells' (CSCs), the most malignant cells in the tumor and those responsible for recurrence, spread, and therapy resistance. We found that these CSCs are addicted to a molecule called LINC01133, a member of the long non-coding RNA family, and that LINC01133 promoted the formation of an immune-suppressed tumor microenvironment consistent with it fostering immune evasion. Here, we will elucidate LINC01133 immune pro-malignant functions and determine its utility as a therapeutic target in preclinical models, thereby introducing novel RNA immunotherapeutics of potential groundbreaking impact in managing aggressive and difficult-to-treat TNBCs.

PI_NAMEs: KARNOUB, ANTOINE ELIAS (contact)

PROJECT_TERMS: 3-Dimensional;Affinity;African Women;anergy;Antisense Oligonucleotides;Antitumor Response;aptamer;Attenuated;Behavior;Binding;Biological Assay;Biological Markers;Breast Cancer Cell;Breast Cancer Model;Breast Carcinoma;cancer cell;cancer regression;cancer stem cell;cancer type;CD3 Antigens;Cell Death;cell killing;Cell Physiology;Cells;Chimera organism;Clinic;Clinical;Clinical Management;clinically relevant;Code;cohort;comparative;Connective Tissue;Coupling;Cultured Cells;Data;Databases;Development;Disease;Disease Management;effective therapy;Event;exhaust;exhaustion;Exhibits;experimental study;Family;Fostering;Generations;Genes;Genetically Engineered Mouse;Genomics;Growth;Histologic;Homeostasis;Immune;immune cell infiltrate;immune checkpoint;Immune checkpoint inhibitor;Immune Evasion;Immunocompetent;Immunohistochemistry;Immunooncology;Immunotherapeutic agent;In Vitro;in vivo;Infiltration;Inhibition of Cancer Cell Growth;inhibitor;Kinetics;knock-down;Lasers;Latino;Link;Lymphocyte;Macrophage;Maintenance;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Epithelial Cell;Malignant Neoplasms;Mammary Neoplasms;Mass Spectrum Analysis;Mediating;member;Mesenchymal;Messenger RNA;Modeling;Molecular;Molecular Probes;Morphology;mRNA Stability;Mus;Myeloid-derived suppressor cells;Neoplasm Metastasis;new therapeutic target;novel;overexpression;paracrine;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Patients;perforin;pharmacologic;Phenotype;Play;pluripotency;pre-clinical;Pre-Clinical Model;Production;progenitor;prognostication;programmed cell death ligand 1;Proteins;Receptor Cell;Recording of previous events;Recurrence;Refractory Disease;Resistance;RNA;RNA Binding;Role;Signal Transduction;Small Interfering RNA;Specimen;stem;stemness;Stromal Cells;Structure;Surface;Survival Rate;T-Lymphocyte;TACSTD1 gene;targeted treatment;Testing;therapeutic target;TIS11 protein;transcriptomics;triple-negative invasive breast carcinoma;tumor;tumor growth;Tumor Immunity;tumor initiation;tumor microenvironment;tumor progression;Tumor-associated macrophages;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;tumorigenesis;tumorigenic;Untranslated RNA;Up-Regulation;Veterans;Woman;young woman

PROJECT_TITLE: The long non-coding RNA LINC01133 as a novel determinant of immune evasion in triple-negative breast cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 CAMM-P (01)]


NIH_SPENDING_CATS: Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pain Research;Palliative Care

ORG_DEPT: NEUROSURGERY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Despite multimodal palliative care, pain remains one of the most common symptoms for those with advanced cancer. In a prospective study, patients with refractory, one-sided cancer pain who were randomized to cordotomy experienced greater pain relief that those patients randomized to continued palliative care. To control for placebo effect, in this proposal we will undertake a single-institution, sham controlled clinical trial to determine the extent to which cordotomy is effective in reducing advanced cancer pain.

PI_NAMEs: VISWANATHAN, ASHWIN  (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: Activities of Daily Living;Adoption;Advanced Malignant Neoplasm;arm;Biological Markers;cancer pain;Chest wall structure;Clinical Trials;common symptom;Controlled Clinical Trials;Cordotomy;Data;Diffusion Magnetic Resonance Imaging;Double-Blind Method;efficacy evaluation;Emergency department visit;end of life;experience;Failure;Goals;hospital readmission;Image;implementation facilitation;improved;Institution;Intervention;Interview;Intractable Pain;Knowledge;Leg;Lesion;Magnetic Resonance Imaging;Malignant Neoplasms;Measures;Medical;minimally invasive;multimodality;Pain;Pain Free;Pain intensity;Pain interference;pain outcome;pain reduction;pain relief;pain score;palliation;Palliative Care;Pathway interactions;Patient Selection;Patients;Placebo Control Effect;Placebo Effect;prevent;primary endpoint;Procedures;programs;prospective;Prospective Studies;Publishing;Qualitative Research;Randomized;Recurrent pain;Refractory;refractory cancer;Research Methodology;Resolution;responders and non-responders;Risk;Role;Series;Side;Spinal Cord;Spinal Cord Lesions;Spinothalamic Tracts;surgical pain;Symptoms;Techniques;Testing

PROJECT_TITLE: Percutaneous Cordotomy for Pain Palliation in Advanced Cancer

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: ATLANTA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE This project aims to identify the enzymes behind the collagen and gelatin degrading activities observed in C. difficile and examine their potential role as colonization factors. Elucidating factors that allow C. difficile to colonize the gut to cause disease can provide novel targets for development of therapeutics to prevent or treat these troublesome infections.

PI_NAMEs: VARGAS-CUEBAS, GERMAN GABRIEL (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Amino Acids;antibiotic-associated diarrhea;Bacteria;Cells;Cessation of life;Clostridium difficile;Collagen;collagenase;Colon;Data;defined contribution;Disease;enzyme activity;Enzymes;gastrointestinal;Gastrointestinal tract structure;Gelatin;Gelatinases;Germination;Glycine;Goals;Growth;gut colonization;Health Care Costs;host colonization;Human;Human body;improved;Infection;Inflammatory Response;Ingestion;Intestines;Knowledge;Mammals;novel;Nutrient;Nutrient availability;Outcome;pathogen;Pathogenesis;Penetration;Peptide Hydrolases;prevent;Prevention;Proline;Proteolysis;Reproduction spores;Role;Salmonella typhimurium;Source;Specificity;Testing;therapeutic development;Tissues;Toxin;transmission process;United States;Virulence;Virulence Factors;Virulent

PROJECT_TITLE: Investigating the impact of collagenase in Clostridioides difficile pathogenesis


ORG_CITY: Decatur

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: The current standard of care for unresectable Stage III non-small cell lung cancer (NSCLC) is immunotherapy (IO), specifically durvalumab, in conjunction with chemoradiation. However, it is not clear that all Stage III NSCLC patients will receive benefit from durvalumab, apart from not receiving added benefit from IO, they are also likely to suffer from IO related adverse effects like pneumonitis. Additionally, the cost of IO is extremely high, >$140K/year per patient. The goal of this project is to develop novel computational radiomic tools which with routine CT scans could help identify those Veterans with Stage III NSCLC who could (1) potentially avoid immunotherapy since it might not confer added benefit over chemoradiation alone, (2) determine when a disease stable status has been achieved so that an IO duration prediction can be made (6 vs 12 months), and (3) predict adverse events like pneumonitis to inform Veteran care.

PI_NAMEs: MADABHUSHI, ANANT  (contact);NOCK, CHARLES J

PROJECT_TERMS: Adverse effects;Adverse event;American Society of Clinical Oncology;Artificial Intelligence;Biological;Biological Markers;Biopsy;cancer diagnosis;cancer immunotherapy;Cancer Patient;Caring;Cessation of life;chemoradiation;Chemotherapy and/or radiation;Clinic;Clinical;Clinical Trials;Computers;cost;Cost Savings;Data;Development;Diagnosis;Disease-Free Survival;Goals;Habitats;Healthcare Systems;Image;Immune;Immune checkpoint inhibitor;Immune system;immune- related response criteria;immune-related adverse events;Immuno-Chemotherapy;Immunotherapy;Maintenance;Malignant neoplasm of lung;Molecular;Morbidity - disease rate;Morphology;Mutation;New York;Nodule;Non-Small-Cell Lung Carcinoma;novel;Ohio;optimal treatments;Outcome;Pathway interactions;Patients;Pattern;PD-1/PD-L1;Pharmaceutical Preparations;Placebos;Prediction of Response to Therapy;predictive marker;prognostic;programmed cell death ligand 1;Progression-Free Survivals;Publications;Publishing;Pulmonary Inflammation;Quality of life;Radiation;radiological imaging;radiomics;Regimen;response;Shapes;Stable Disease;standard of care;success;Survival Rate;Texture;tool;Toxic effect;Travel;treatment duration;Treatment Protocols;tumor;tumor microenvironment;Universities;University Hospitals;Unresectable;Veterans;Veterans Health Administration;Work;X-Ray Computed Tomography

PROJECT_TITLE: RadIO: A Novel Radiomics Toolkit to Predict and Characterize Response to Immunotherapy in Stage III Non-Small Cell Lung Cancer


PHR: Rheumatoid arthritis (RA) is relevant to veteran’s health given the increased number of women veterans and the increased risk for RA with posttraumatic stress disorder. A study of the Veterans Affairs Rheumatoid Arthritis registry demonstrated the mortality rate among veterans with RA to be twice that of veterans without RA. Our recent studies indicate that the gut microbiome plays important roles in RA treatment and that MTX acts on the microbiota to reduce inflammation. Our studies will examine microbiota in veteran RA patients starting methotrexate and utilize these samples to elucidate the molecular mechanisms by which MTX acts on the microbiota. Doing so will lay the groundwork for development of a precision medicine approach that will enhance treatment response to MTX.

PI_NAMEs: NAYAK, RENUKA RAJENDRA (contact)

PROJECT_TERMS: Adenosine;Affect;Anti-Inflammatory Agents;Antibiotic Resistance;Antiinflammatory Effect;arthritis registry;Autoimmune Diseases;Bacteria;Bacteroides thetaiotaomicron;Blood;Consumption;cost effective;Data;Death Rate;design;Development;Dose;Enzymes;Escherichia coli;extracellular;fecal microbiome;Feces;fitness;Folic Acid;folic acid metabolism;Foundations;Genes;Genetic Determinism;Gnotobiotic;Goals;Growth;gut microbiome;gut microbiota;Health;host microbiota;Human;immune activation;Immunity;immunoregulation;improved;in vivo;Individual;Inflammation;Inflammatory Arthritis;inhibitor;innovation;Knowledge;Libraries;Link;Measures;Methotrexate;Microbe;microbial;Microbial Genetics;microbial genomics;microbiome;microbiota;Molecular;mouse model;Mus;mutant;Pathway interactions;patient response;Patients;Pharmaceutical Preparations;pharmacologic;Play;Population;Post-Traumatic Stress Disorders;precision medicine;Prevalence;resident commensals;response;Rheumatism;Rheumatoid Arthritis;Rheumatology;Risk;Role;Sampling;Shapes;skin disorder;T-Lymphocyte;targeted treatment;Testing;Transplantation;treatment response;United States Department of Veterans Affairs;Veterans;Woman

PROJECT_TITLE: Identifying and targeting gut microbial mechanisms that contribute to methotrexate response in rheumatoid arthritis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 IMMA-G (01)]


PHR: Alzheimer’s disease is the sixth leading cause of death in the general population and develops at a 60% higher rate in the Veteran Population. Traumatic brain injury and post-traumatic stress disorder, common in the Veteran Population, are associated with the development of amyloid pathology and cognitive decline, causing significant morbidity to Veterans and their families. Altered plasticity and neurotransmitter pathways are strongly implicated in cognitive dysfunction associated with Alzheimer’s disease. Here, we propose to use state of the art in vivo calcium imaging and single-cell-specific spatial transcriptomic microscopy to dissect how neuronal plasticity mechanisms degrade as a function of distance from b-amyloid foci in the 5xFAD mouse model of amyloid deposition. Understanding the mechanisms of plasticity dysfunction at the circuit level promises to yield new therapeutic targets for ameliorating Alzheimer’s cognitive sequelae in the future. This underscores the high potential impact of this project for the Veteran Population.

PI_NAMEs: SMIRNAKIS, STELIOS MANOLIS (contact)

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease model;Amyloid;Amyloid deposition;amyloid pathology;area V1;Behavioral;Biological Markers;Calcium;Cause of Death;cell type;Cells;Chemosensitization;Chronic;Cognitive;cognitive function;Conscious;Deposition;Deterioration;Development;Disease;Disease Progression;environmental change;Failure;Family;Fluorescent in Situ Hybridization;Functional disorder;functional restoration;Future;General Population;Goals;hippocampal pyramidal neuron;Homeostasis;Hyperactivity;Image;Impaired cognition;In Vitro;in vivo;in vivo calcium imaging;in vivo imaging;Interneurons;Learning;Link;Location;Maps;Measurement;Measures;Memory;Microscopy;military veteran;Molecular;Morbidity - disease rate;mouse model;mRNA Expression;Mus;Neocortex;neocortical;Nerve Degeneration;Nervous System Disorder;neural;Neuroglia;neuronal circuitry;Neuronal Plasticity;Neurons;Neurotransmitter Receptor;Neurotransmitters;new therapeutic target;Pathology;Pathway interactions;pharmacologic;Phase;Phylogenetic Analysis;Play;Post-Traumatic Stress Disorders;Process;Property;response;response biomarker;Role;Senile Plaques;Shapes;Signal Recognition Particle;Sleep;Stimulus;Synaptic plasticity;tau Proteins;Techniques;therapy design;Time;Tissues;Training;transcriptomics;Traumatic Brain Injury;two-photon;Veterans;Visual Cortex;Visual evoked cortical potential;visual learning

PROJECT_TITLE: Cell-specific plasticity pathway dysfunction as a result of amyloid deposition in Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 NURD-E (01)]


ORG_CITY: MADISON

ORG_NAME: WM S. MIDDLETON MEMORIAL VETERANS HOSP

ORG_STATE: WI

PHR: Despite the recent breakthroughs in treatment of melanoma, there are still no durable treatments for this cancer. There is a need to explore and find novel avenues to diagnose and treat melanoma in its early stages and prevent its progression to deadly metastatic cancer. Excessive exposure to ultraviolet radiation, as experienced by many US military personnel serving outdoors and on high seas in tropical and subtropical zones, poses a significant risk of developing melanoma, which might manifests after many years after active service. Once diagnosed with cutaneous melanoma, management of the Veterans’ treatment is dictated by the clinical staging of the disease. The goal of the proposed research is to develop a sensitive method to detect melanoma cells in the blood of Veterans diagnosed with melanoma on the skin as an indicator of risk of developing deadly metastatic diseases. This research has the potential to yield new knowledge that will impact management of Veterans diagnosed with early stage melanoma.

PI_NAMEs: SETALURI, VIJAYASARADHI  (contact)

PROJECT_TERMS: active duty;Aftercare;Antibodies;Appearance;Behavior;Biochemical;Biological Markers;Biosensing Techniques;Biosensor;Blood;Blood specimen;cancer diagnosis;Cancer Patient;cancer therapy;Carcinoma;Cell Adhesion Molecules;Cell surface;Cell Surface Proteins;Cells;Characteristics;chemotherapy;Clinical;Colorectal Cancer;Country;Cutaneous;Cutaneous Melanoma;Detection;detection platform;Development;Devices;Diagnosis;Disease;disease prognosis;Disseminated Malignant Neoplasm;Distant;draining lymph node;Early Diagnosis;Epithelial Cells;Excision;Exercise;experience;extracellular vesicles;FDA approved;fluorescence imaging;Gene Expression Profiling;Goals;Heterogeneity;Human;Immunotherapy;improved;In Vitro;Incidence;Individual;Knowledge;Label;Lesion;liquid biopsy;Lymphatic;macromolecule;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Melanocortin 1 Receptor;melanocyte;Melanoma;Melanoma Cell;metabolic imaging;Metastatic Melanoma;Methods;Microfluidic Microchips;Microfluidics;MicroRNAs;Military Personnel;military veteran;Molecular;Monitor;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;novel;Optics;Organ;Patient-Focused Outcomes;Patients;peripheral blood;Phenotype;phenotypic biomarker;prevent;Primary Lesion;Primary Neoplasm;Prognosis;prognosis biomarker;Prognostic Marker;prognostic significance;protein biomarkers;Proteins;Proteomics;rapid detection;Receptor Cell;Research;Risk;risk prediction;Sea;single cell genomics;Skin;skin lesion;solar radiation;Specificity;Staging;Stream;Surface;Surface Antigens;Survival Rate;Thick;Thinness;Time;Tissues;tool;Training;transcriptome;transcriptome sequencing;tumor;tumor DNA;Tumor-Derived;UV Radiation Exposure;Veterans

PROJECT_TITLE: Immuno-electrochemical Detection and Characterization of Melanoma Circulating Cells


ORG_CITY: BUFFALO

ORG_NAME: VA WESTERN NEW YORK HEALTHCARE SYSTEM

PHR: Ischemic heart disease continues to be the leading cause of death and disability in the United States, impacting the lives of millions of Veterans each year. Cardiomyocyte cell death plays a significant role in left ventricular remodeling and cardiac dysfunction following myocardial infarction (MI) and ischemia-reperfusion (I/R). This project seeks to elucidate the mechanism/s of action of a cardioprotective exosome population and identify therapeutic targets to reduce cardiomyocyte cell death in pathways operant in I/R. Furthermore, completion of this project will yield improved strategies to optimize therapeutic exosome delivery in a cell-specific manner to increase efficacy and decrease off-target effects. This would enhance the treatment of Veterans with a wide spectrum of cardiac disease including heart failure and myocardial infarction.

PI_NAMEs: LANG, JENNIFER K (contact)

PROJECT_TERMS: Acute;Acute myocardial infarction;Address;Adult;Animal Model;Animals;Apoptosis;Biological;Blood flow;Cardiac;Cardiac Myocytes;cardiac repair;cardioprotection;Cardiovascular system;Cause of Death;Cell Death;Cell secretion;Cells;Clinical;clinical translation;clinically relevant;Coronary;Data;delivery vehicle;Development;disability;Disease;disease model;Dose;Drug Kinetics;early phase clinical trial;engineered exosomes;Engineering;exosome;Goals;Heart;Heart Diseases;Heart failure;heart function;improved;Infarction;innovation;Ischemia;Knowledge;Left Ventricular Remodeling;Mediating;Medicine;Membrane Proteins;MicroRNAs;Modeling;Modification;Morbidity - disease rate;mortality;mouse model;Muscle Cells;Myocardial dysfunction;Myocardial Infarction;myocardial injury;Myocardial Ischemia;Myocardial Reperfusion Injury;nanosized;novel;novel therapeutic intervention;Outcome;Pathway interactions;Patients;Peptides;percutaneous coronary intervention;pharmacokinetics and pharmacodynamics;Play;Population;porcine model;pre-clinical;Pre-Clinical Model;preclinical efficacy;preclinical evaluation;preclinical study;Protein Engineering;regeneration potential;Regenerative capacity;repaired;Reperfusion Injury;Reperfusion Therapy;Research;Risk;Role;Route;Series;success;Surface;Testing;Therapeutic;therapeutic miRNA;therapeutic target;therapy outcome;Tissues;Translating;translational potential;translational therapeutics;Translations;Treatment Efficacy;treatment strategy;United States;Vesicle;Veterans;Work

PROJECT_TITLE: Enhancing the translational potential of therapeutic exosomes for ischemic heart disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 CARA-R (01)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Rehabilitation;Preterm, Low Birth Weight and Health of the Newborn;Rehabilitation;Stroke

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

PHR: Perinatal arterial ischemic stroke (PAS) occurs in an estimated 1 in 1150 livebirths and often leads to serious lifelong neuromotor impairment. This StrokeNet Phase III trial will provide definitive efficacy data about an intensive form of infant rehabilitation (Infant ACQUIRE) to transform rehabilitation and improve clinical outcomes.

PI_NAMEs: LO, WARREN DAVID;RAMEY, SHARON LANDESMAN (contact)

PROGRAM_OFFICER_NAME: AFZAL, MARIAM MASHEEB

PROJECT_TERMS: Address;Aftercare;Behavior;blind;Blinded;Childhood;Clinical;Clinical Protocols;Clinical Trials;Clinical Trials Design;Code;Cognition;cognitive function;constraint induced movement therapy;cost;Data;design;Development;Diagnosis;disability;Documentation;dosage;Dose;Double-Blind Method;efficacy evaluation;efficacy outcomes;evidence base;Evidence based treatment;Family;family burden;Goals;Hand;Healthcare Systems;hemiparesis;Home;Impairment;implementation tool;improved;Incidence;Infant;Infant Care;infant outcome;Live Birth;Maintenance;Manuals;meetings;Monitor;Motor;Motor Skills;MRI Scans;Neonatal ischemic stroke;Neurological status;Neurologist;Operant Conditioning;Outcome;Parents;patient engagement;Patients;perinatal ischemic stroke;Phase;phase III trial;Protocols documentation;Public Health;Quality of life;Randomized;Randomized, Controlled Trials;Rehabilitation therapy;Research;Safety;Shapes;Side;Site;skills;Societies;standard of care;Standardization;Statistical Data Interpretation;Stroke;stroke incidence;Techniques;Testing;theories;tool;Training;treatment effect;treatment group;Treatment outcome;trial comparing;United States National Institutes of Health;Upper Extremity;Variant;Videotape

PROJECT_TITLE: Perinatal Arterial Stroke: A Multi-site RCT of Intensive Infant Rehabilitation (I-ACQUIRE)