ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Substance Misuse

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

PHR: This R21 application, “Serum Exosome Detection and Monitoring of Alcohol-related White Matter Brain Pathology-Opportunities to Optimize Treatment and Monitoring of AUD-Related Organ and Tissue Damage in Diverse Populations” leverages gains from ongoing preclinical studies to logically extend the initial plan by utilizing serum-derived extracellular vesicles (EVs) to non- invasively detect oligodendrocyte-related white matter (WM) degeneration in humans with alcohol-related brain degeneration (ARBD). Banked serum samples from alcohol use disorder (AUD) subjects who participated in longitudinal monitoring or intervention (motivational interview or pharmacologic) trials in which the outcomes are known, will be used to characterize alterations in oligodendrocyte protein, sphingolipid expression, and indices of oxidative stress over time and in relation to disease progression or treatment. The results of this R21-supported research will facilitate a path for future clinical trials to non-invasively monitor progression and treatment responses in patients with AUD and WM ARBD from diverse socioeconomic backgrounds.

PI_NAMEs: DE LA MONTE, SUZANNE M. (contact)

PROGRAM_OFFICER_NAME: SENEVIRATNE, CHAMINDI

PROJECT_TERMS: Abstinence;Administrative Supplement;Aftercare;Alcohol consumption;alcohol effect;alcohol exposure;alcohol monitoring;alcohol research;alcohol use disorder;Alcoholic beverage heavy drinker;Alcohols;Atrophic;Baclofen;Behavior;Behavioral;bench to bedside;binge drinking;Biochemical;Biological Markers;Brain;Brain Injuries;Brain Pathology;brief intervention;Ceramides;Chronic;Clinical;clinical translation;Clinical Trials;Cognitive;Collaborations;comparative;Comparative Study;Counseling;craving;Detection;detection assay;Diagnostic;disability;Disease Progression;Enhancers;Enzyme-Linked Immunosorbent Assay;exosome;experimental study;extracellular vesicles;Feasibility Studies;Florida;FRAP1 gene;Functional disorder;Funding;Future;ghrelin;Glycoproteins;Goals;Human;human data;human study;Impairment;indexing;Inflammation;insight;Institutional Review Boards;Insulin;Insulin-Like Growth Factor I;Intervention;Intervention Studies;Laboratory Study;Light;Lipid Peroxidation;Lipids;Longitudinal Studies;Measures;Metabolism;Modeling;Molecular;Molecular Analysis;molecular pathology;Monitor;motivational enhancement therapy;motivational intervention;multimodality;Myelin;myelin degeneration;Myelin Proteins;National Institute of Drug Abuse;National Institute on Alcohol Abuse and Alcoholism;neurobehavioral;neuroimaging;neuroregulation;Non-Invasive Detection;non-invasive monitor;oligodendrocyte-myelin glycoprotein;Oligodendroglia;Organ;Outcome;Outcomes Research;Oxidative Stress;Participant;Pathology;Patient Care;Patient Participation;Patients;PDGFRA gene;Performance;Peripheral;pharmacologic;PIK3CG gene;Placebos;Population;Population Heterogeneity;preclinical study;preference;Process;prospective;Proteins;Protocols documentation;Psychological reinforcement;Rattus;Research;Research Support;response;Rodent;Sampling;Sensitivity and Specificity;Serum;Signal Transduction;socioeconomics;Sphingolipids;Sphingomyelins;Stress;Sulfoglycosphingolipids;targeted treatment;Technology;Time;Tissues;treatment optimization;treatment response;Underserved Population;Universities;white matter

PROJECT_TITLE: Serum Exosome Detection and Monitoring of Alcohol-Related White Matter Brain Pathology-Opportunities to Optimize Treatment and Monitoring of AUD-Related Organ and Tissue Damage in Diverse Populations

STUDY_SECTION: AA

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


ADMINISTERING_IC: AR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative: This work is a mechanistic study of innate and adaptive immune responses in systemic lupus erythematosus (SLE). Having made a novel discovery of autoantibodies against Cyclic G/AMP (cGAMP) synthetase (cGAS) in SLE patients with active disease, we will examine the impact of biophysical changes triggered by cGAS ligand binding on the loss of tolerance to this antigen. This work may help explain why nucleic acid-binding proteins are both autoantigens and drivers of inflammation in SLE.

PI_NAMEs: ANTIOCHOS, BRENDAN  (contact);SOHN, JUNGSAN ;TINIAKOU, ELENI

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: adaptive immune response;Antibodies;Antigen Presentation;antigen processing;Antigen-Presenting Cells;Antigens;Apoptotic;Autoantibodies;Autoantigens;Autoimmune Diseases;Automobile Driving;Binding;Biological Assay;Biophysics;Cells;Characteristics;Clinical;cohort;Complex;Confocal Microscopy;Data;Dendritic cell activation;Dendritic Cells;dimer;Dimerization;Disease;disenfranchised population;Disproportionately impacts women;DNA;DNA Binding;Double-Stranded RNA;ds-DNA;Epitopes;Ethnic Origin;Exposure to;Flow Cytometry;Future;Gel;Gene Expression Profiling;Generations;Hybrids;Hydrogels;Immune;Immune response;immunopathology;improved;Inflammation;injured;Innate Immune Response;Interferon Activation;Interferons;Ligand Binding;Ligands;Ligase;Link;Liquid substance;Minority;Molecular;monocyte;monomer;Morbidity - disease rate;novel;Nucleic Acid Binding;nucleic acid binding protein;Nucleic Acids;Pathogenesis;Pathway interactions;Patients;peptide synthase;Periodicity;Phase;Physical condensation;Production;prognostic;Proteins;Race;Recombinant Proteins;Research;response;Rest;Rheumatism;rheumatologist;RNA;Role;Second Messenger Systems;sensor;Shapes;Signal Transduction;Single-Stranded DNA;Systemic Lupus Erythematosus;Testing;theories;Therapeutic;Tissues;uptake;Work

PROJECT_TITLE: Delineating the interplay between nucleic-acid-dependent phase separation and immune responses against cGAS in SLE

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ADMINISTERING_IC: DK

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Congenital Structural Anomalies;Kidney Disease;Pediatric;Regenerative Medicine

ORG_CITY: Newark

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Narrative The functional units of the kidney, the nephrons, are established during development and do not regenerate later in life resulting in kidney failure after injury, disease, or age with the only cure being kidney transplant. Here we develop an easy-to-use modular 3D model of the developing nephron in which the biophysical and biochemical cues of the ECM, soluble factors, and stromal cell identity can be spatially patterned along the length of an epithelialized tube. This model will be designed such that it can be easily disseminated to the research community to rapidly increase mechanistic investigation of nephrogenesis for biological understanding, pharmacological screening, and tissue engineering applications.

PI_NAMEs: GLEGHORN, JASON PAUL (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: 3-Dimensional;Address;Adoption;Age;Animal Model;Animals;Biochemical;Biochemical Process;Biological;Biological Models;Biophysical Process;biophysical properties;Biophysics;Blood;Cell model;Cell Physiology;Cell Proliferation;Cells;chemical reaction;Communities;cost;crosslink;Cues;design;Development;Device Designs;Differentiation Antigens;Disease;disease model;drug development;drug testing;Electrolytes;Embryo;Embryonic Development;End stage renal failure;Endowment;Epithelial Cells;Epithelial-Stromal Communication;Epithelium;Equipment;Ethics;Extracellular Matrix;fabrication;Feedback;Fibroblasts;Fluid Balance;fluid flow;Gene Expression;Hydrogels;In Vitro;in vitro Model;induced pluripotent stem cell;Injury;insight;Instruction;interstitial;Investigation;Kidney;Kidney Diseases;kidney dysfunction;Kidney Failure;Kidney Transplantation;Length;Life;Measures;Mesenchymal;Metabolic;Microfluidic Microchips;Microfluidics;microphysiology system;Modeling;morphogens;Morphology;Motility;Natural regeneration;nephrogenesis;Nephrons;nephrotoxicity;novel;open source;Organogenesis;Organoids;Pathology;Pattern;pharmacologic;Phenotype;Population;Positioning Attribute;Property;Protocols documentation;renal damage;Reproducibility of Results;Research;Research Personnel;Risk;Role;screening;Signal Pathway;Signaling Molecule;Specific qualifier value;Speed;Stromal Cells;System;Techniques;Technology Transfer;Therapeutic;three-dimensional modeling;Tissue Engineering;Tissues;tool;Tracer;Tube;Urine;user-friendly;Variant;Visualization;wasting;web site

PROJECT_TITLE: Nephrogenesis on a chip: an simple modular platform to spatially pattern extracellular matrix, stromal cells, and soluble factors

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Contraception/Reproduction;Hematology;Pain Research;Rare Diseases;Sickle Cell Disease;Urologic Diseases

ORG_CITY: TALLAHASSEE

ORG_DEPT: NUTRITION

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative: Erectile Dysfunction is highly prevalent in American men, the severity of which is believed to be due in part to decreased oxygenation of the corpus cavernosum. The current method for measurement of penile oxygenation is through needle aspiration of penile blood, which is impractical for prolonged monitoring purposes due to patient discomfort and potential of further tissue damage. We seek to leverage our team’s recent innovation of a stretchable and flexible photodiode to create a wearable device for prolonged penile oxygen tension measurement that contours to the skin and stretches with movement, which we first seek to optimize and validate in a rodent model.

PI_NAMEs: LAFAVOR, JUSTIN DAVID (contact);YU, ZHIBIN

PROGRAM_OFFICER_NAME: KIRKALI, ZIYA

PROJECT_TERMS: Affect;American;aspirate;Back;base;Blood;Blood flow;blood perfusion;Characteristics;Clinical;Collagen;cost;Depressed mood;design;Development;Devices;Diagnostic;Discontinuous Capillary;Disease;Disodium Salt Nitroprusside;Electric Stimulation;Erectile dysfunction;erection;fabrication;Fascia;Fibrosis;flexibility;Geometry;Goals;Hematological Disease;hemodynamics;Hemoglobin;Human;Hypoxia;Image;imaging probe;Injections;innovation;Intervention;Ischemia;Kidney Diseases;Life Style;Light;light emission;light intensity;Male Genital Organs;Measurement;Measures;men;Methods;miniaturized device;Monitor;monitoring device;mouse model;Movement;Mus;Needles;Nerve;novel;optical sensor;Optics;Oxygen;Papaverine;Patients;Penetration;penis;pharmacologic;Photoplethysmography;physical property;Population;pressure;Priapism;Process;Progressive Disease;prototype;Rattus;Records;response;Risk;Rodent;Rodent Model;sensor;Severities;Sickle Cell;Sickle Cell Anemia;Signal Transduction;Silicones;Skin;Sleep;Smooth Muscle;Source;Stretching;subcutaneous;Technology;technology development;technology validation;Testing;Thick;Time;Tissues;tool;tool development;Tunica Albuginea;ultrasound;Urologic Diseases;Venous;Visible Radiation;voltage;wearable device;Work

PROJECT_TITLE: Development of stretchable optical sensors for measurement of penile hemodynamics


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Cancer;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: WINSTON-SALEM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE Although low-dose computed tomography screening lowers lung cancer death rates, it is widely underused, especially among groups experiencing health inequities. This project will adopt a new method to assess the real-world equity impact and cost-effectiveness of three different lung cancer screening strategies: the United States Preventive Services Task Force guidelines, the American Cancer Society guidelines, and an approach based on a lung cancer risk prediction model. Project results will inform lung cancer screening programs focused on equity, thereby enhancing the availability and utilization of lung cancer screening, especially for communities experiencing health disparities and bearing the greatest risk of lung cancer.

PI_NAMEs: LIN, MENG-YUN  (contact);RICHMOND, JENNIFER ANN

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Address;Adopted;Adult;Advisory Committees;Age;aged;American;American Cancer Society;analytical tool;Black American;Black Populations;black women;Cancer Death Rates;cancer diagnosis;Cancer Etiology;cancer risk;Cessation of life;Communities;community advisory board;computed tomography screening;cost effective;cost effectiveness;Cost Effectiveness Analysis;Cost Measures;Critiques;Data;Decision Making;design;Development;Dimensions;Disparity;Disparity population;early onset;economic evaluation;Eligibility Determination;Equity;Ethnic Origin;experience;Family history of;General Population;Goals;Guidelines;Health;Health Benefit;health disparity;health inequalities;high risk;Improve Access;improved;Individual;Inequity;insight;Intervention;Intuition;low dose computed tomography;low socioeconomic status;lung cancer screening;lung health;Malignant neoplasm of lung;men;Methods;Modeling;mortality risk;novel;Outcome;Persons;Policies;Population;population health;Preventive service;programs;Race;Recommendation;Research;response;Risk;risk prediction model;Risk Reduction;screening;screening program;Smoke;Smoking;smoking cessation;Smoking History;Social Welfare;Socioeconomic Status;socioeconomics;Subgroup;Testing;tool;United States Preventative Services Task Force;Update;uptake;user-friendly;Visualization;Work

PROJECT_TITLE: Equity Implications of Lung Cancer Screening Strategies for Population Health: a Distributional Cost-Effectiveness Analysis

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Infectious Diseases;Machine Learning and Artificial Intelligence;Microbiome;Networking and Information Technology R&D (NITRD);Pediatric;Prevention

ORG_CITY: CHAPEL HILL

ORG_DEPT: DENTISTRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Microbial imbalances are the basis of several oral and dental diseases and can be studied using high-throughput DNA and RNA sequencing methods. The ZOE 2.0 study investigated early childhood caries (ECC) and collected matched microbial DNA, RNA, and metabolomics data in a community-based sample of 300 3-5-year-old children, creating the largest cohort with this biological information in the oral health domain. We propose to advance our understanding of associations and biological interactions among microbial species and their relationship with ECC. We will accomplish this by identifying regulatory modules across all omics layers by developing a new clustering method. Next, we will leverage these multi-omics data by employing machine learning methods to identify ECC-predictive omics features and ultimately predict ECC status.

PI_NAMEs: WU, DI  (contact)

PROGRAM_OFFICER_NAME: OKI, NOFFISAT

PROJECT_TERMS: 5 year old;Address;Age;Behavioral;biobank;Biochemical;Biological;Biological Markers;Biological Process;Biology;Board Certification;candidate identification;Child;Childhood;Clinical;Code;cohort;Collaborations;Communities;Complex;Computer software;Data;Data Analyses;Data Set;Dental;dental biofilm;Dental caries;Dentists;Detection;Diagnosis;Disease;DMF Index;DNA;DNA sequencing;dysbiosis;early childhood;early detection biomarkers;Early identification;economic impact;Enrollment;Environment;Evaluation;experience;explainable machine learning;feature selection;Funding;Future;Gene Expression;Genetic Transcription;Genome;Genomics;Health;Healthcare;high dimensionality;High-Throughput DNA Sequencing;High-Throughput Nucleotide Sequencing;Human;improved;Individual;innovation;insight;Investigation;Joints;learning strategy;Light;liquid chromatography mass spectrometry;Machine Learning;machine learning method;machine learning model;machine learning prediction;Metabolic;metabolome;metabolomics;Metagenomics;metatranscriptomics;method development;Methods;microbial;Microbial Biofilms;microbial community;microbiome;Modality;Motivation;Mouth Diseases;Multiomic Data;National Institute of Dental and Craniofacial Research;North Carolina;novel;novel strategies;Nursery Schools;Oral;Oral health;Oral Microbiology;oral microbiome;Parents;Participant;Pathogenesis;Performance;Periodontitis;precision medicine;predictive modeling;prevent;Prevention;Process;programs;Public Health;Publications;Qualifying;Recording of previous events;Regulation;Research;Research Project Grants;Resolution;RNA;Sampling;School-Age Population;Statistical Methods;Statistical Models;stem;Taxonomy;Technology;Testing;Tooth Diseases;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Whole-Genome Shotgun Sequencing

PROJECT_TITLE: Investigating the microbial basis of early childhood caries via integrative analysis of metagenomics metatranscriptomics and metabolomics

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 TO (19)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: BROOKLYN

ORG_NAME: SUNY DOWNSTATE MEDICAL CENTER

ORG_STATE: NY

PHR: Project Narrative Building upon our MIRA R35 award, this administrative supplement introduces a novel online course designed to empower biomedical researchers to foster robust mentorship networks through the NRMN platform. It aims to enhance research outcomes and bridge mentorship gaps of more than 300 researchers—potentially thousands—contributing to a more diverse biomedical workforce.

PI_NAMEs: LAMBERT, WILLIAM MARCUS (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Address;Administrative Supplement;Area;Award;Biological Sciences;Biomedical Research;career;Career Choice;Career Mobility;college;course module;Data;Dedications;Democracy;design;Development;education resources;Educational Status;Effectiveness;empowerment;Ensure;Environment;Equity;Ethnic Origin;experience;Faculty;Fostering;Funding;Gender;Goals;Grant;improved;Individual;innovation;insight;Knowledge;Learning;Measures;Mentors;Mentorship;Modeling;Motivation;Nature;Network-based;novel;online course;Outcome;Outcomes Research;Parents;Participant;Perception;Play;Postdoctoral Fellow;Process;Productivity;Race;Research;Research Personnel;Role;role model;Science;Self Assessment;Self Efficacy;Shapes;skills;social capital;social cognitive theory;Structure;Students;success;Surveys;tool;Training;Underrepresented Populations;United States National Institutes of Health;Validation;Vocational Guidance;Work

PROJECT_TITLE: Understanding the Science of Effective Mentorship Networks for Underrepresented Researchers


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Breast Cancer;Cancer;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Women's Health Research

ORG_CITY: ITHACA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative A major challenge in modeling human disease in animals is the variability in outcomes among individual animals, especially where disease mortality or morbidity limits downstream analyses of affected organs. We have designed new genetic tools to cause disease on only one side (left or right) of paired visceral organs and limbs, focused here on a proof-of-concept in the lungs using mouse models of viral pneumonia and cancer metastases. Our studies will provide new tools to cause disease and track cells in live mice, laying the groundwork for exciting applications in diverse mouse models spanning respiratory disease, arthritis, cancer, hepatitis and many others.

PI_NAMEs: GLUDISH, DAVID W (contact)

PROGRAM_OFFICER_NAME: ZOU, SIGE

PROJECT_TERMS: 2019-nCoV;Abdomen;ACE2;Address;Affect;Alleles;Anatomy;Animals;Arthritis;Autoimmune Diseases;Biological;Biology;Blood;Body System;Bone Tissue;Breast Cancer Model;Bronchopulmonary Dysplasia;Cancer Biology;cancer cell;Cardiac;Categories;cell behavior;Cell Communication;Cells;Chest;Chronic Obstructive Pulmonary Disease;Clinical;Coculture Techniques;Collaborations;Companions;Complement;Complex;Connective Tissue;Contact Tracing;COVID-19 sequelae;Cre driver;Cre lox recombination system;Credentialing;Data;Dedications;design;Developmental Biology;Discipline;Disease;disease model;disease phenotype;Disease Resistance;Disease susceptibility;Dose;Embryo;Engineering;Enhancers;Ensure;Enterobacteria phage P1 Cre recombinase;Environment;Excision;Exhibits;experience;experimental study;Exposure to;Fatty acid glycerol esters;Fibroblasts;Frequencies;Future;Gastrointestinal tract structure;Gene Expression;Genes;Genetic;Genetic Recombination;Hepatitis;Human;human disease;human model;immunoregulation;In Vitro;in vivo;in vivo evaluation;in vivo imaging system;Individual;Infection;Inflammatory;Injections;Injury;innovation;internal control;intravenous injection;Knock-in;Knock-in Mouse;Knockout Mice;Laboratory Animals;Left;Limb structure;Liver;Long COVID;LoxP-flanked allele;Lung;lung metastatic;Malignant Neoplasms;mammary;Mammary gland;Mammary Neoplasms;Metastatic Neoplasm to the Lung;Modeling;Morbidity - disease rate;mortality;mosaic;mouse model;Mus;Neoplasm Metastasis;Neoplasm Transplantation;novel;Organ;Organogenesis;Outcome;Output;Pancreas;paracrine;Pathology;Pathway interactions;polyoma middle tumor antigen;Predisposition;programs;promoter;Protein Isoforms;Proteins;receptor;Recovery;Reporter;Research Personnel;Respiratory Disease;SARS-CoV-2 infection;Side;Signal Transduction;Spleen;Stomach;Structure of parenchyma of lung;success;Susceptibility Gene;System;Testing;Thrombus;Tissues;tool;Transact;transcription factor;Transplantation;tumor;Validation;Viral;Viral Cancer;Viral Pneumonia;Virus Diseases;Virus Receptors;Viscera;Visceral;whole animal imaging;Work

PROJECT_TITLE: The Unilateral Mosaic (UMos): Novel tools to compartmentalize pathology and trace cellular interactions in mouse models of human disease

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Clinical Research;Disability Research;Hearing Loss;Pediatric

ORG_CITY: BOSTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: The parent project aims to understand how deaf children build a vocabulary in sign language, and whether and how this differs for deaf children who have limited exposure to a sign language. The goal of the supplement is to 1) increase the PI’s capacity to mentor scientists from diverse backgrounds, 2) create professional development materials for scientists in ASL, and offer training to a deaf postdoctoral researcher.

PI_NAMEs: CASELLI, NAOMI K. (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Academia;Awareness;Boston;Child;Communication;Communities;Country;deaf;deaf students;design;Development;Doctor of Philosophy;expectation;experience;Exposure to;Face;faculty mentor;Feedback;Film;Goals;Grant;Hearing;Home;innovation;Institution;interest;Interpersonal Violence;Interruption;Language;Language Development;Leadership;Learning;Linguistics;Manuscripts;member;Mentors;Mentorship;next generation;parent grant;parent project;Persons;Population;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;Process;programs;Publications;Publishing;Qualifying;queer;Research;Research Personnel;Research Training;Resources;Role;Sales;Scientist;Sign Language;Statistical Data Interpretation;systemic barrier;theories;Time;Training;training opportunity;Training Programs;Universities;Vocabulary;Work;Writing

PROJECT_TITLE: Effects of input quality on ASL vocabulary acquisition in deaf children

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Dissemination and Implementation Research;Substance Misuse

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: NARRATIVE In 2019, Hispanic/Latinx individuals were awarded 8.6% of the 187,568 doctoral degrees awarded in the US despite accounting for 18.5% of the US population, and African American graduates were awarded 9.2% of degrees awarded despite accounting for 12.5% of the population, a disparity which drives a lack of diversity among faculty at leading health institutions and in the field of substance use research. There is a need to focus on the necessary first step to increasing diversity in substance use treatment and prevention research: getting college-aged scholars of color who have been underrepresented in academic medicine and public health to attend graduate programs at Research 1 (R1; Carnegie very high research activity designation) institutions where rigorous training will enable independence. The primary innovation of this R25 proposal is its ability to deliberately build a substantial and sustainable pathway between six Hispanic-Serving Institutions and New York University to both identify and enroll exceptional underrepresented undergraduate students into a training program that will provide a pathway to doctoral training in substance use research at R1 institutions.

PI_NAMEs: KHAN, MARIA RABIA (contact)

PROGRAM_OFFICER_NAME: HOLMES, ANGELA L

PROJECT_TERMS: Accounting;addiction;Administrative Supplement;African American;Age;aged;Award;Career Choice;career development;Cities;cohort;Collaborations;college;Color;Communication;Dependence;design;Disparity;Doctor's Degree;doctoral student;Drug Addiction;Drug usage;Educational workshop;Enrollment;Ensure;Environment;Epidemiology;equity, diversity, and inclusion;Ethics;Ethnic Origin;Exercise;experience;Exposure to;Faculty;First Generation College Students;Funding;Future;Goals;graduate school;graduate student;hands on research;Health;Hispanic;Hispanic-serving Institution;HIV/HCV;implementation science;innovation;Institution;investigator training;Knowledge;Laboratory Research;Latinx;Latinx population;Leadership;Life;Link;Marketing;medical schools;Medicine;meetings;Mentors;Mentorship;minority undergraduate;National Institute of Drug Abuse;New York;New York City;Opioid;Pathway interactions;peer;peer coaching;peer networks;Persons;Policies;Population;Positioning Attribute;Postbaccalaureate;posters;Prevention Research;programs;prospective;Public Health;Public Speaking;Publications;Qualifying;racial diversity;recruit;Research;Research Activity;Research Methodology;Research Personnel;Resources;response;scaffold;Science;Scientist;Senior Scientist;Site;skills;skills training;social;Strategic Planning;student mentoring;Students;substance use;substance use treatment;success;symposium;Teleconferences;Time Management;Training;training opportunity;Training Programs;treatment research;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Students;Universities;university student;Work

PROJECT_TITLE: Strengthening Pathways between Hispanic-Serving Institutions and Leadership in Addiction Science


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: NARRATIVE Developing engagement and policy translation skills of the next generation of rural cancer researchers will prove critical as many rural states experience rising cancer incidence amidst growing prevalence of cancer survivors. Greater access to comprehensive survivorship services could mitigate the growing mortality disparity between rural-urban cancer patients, but rural cancer centers need additional support to deliver such care locally. Leveraging the resources of an innovative cancer center network intervention, we propose to implement an evidence-based survivorship workshop adapted to fit the unique needs of rural communities and explore innovative approaches to disseminate our cancer equity research to rural policymakers.

PI_NAMEs: CHARLTON, MARY E. (contact)

PROGRAM_OFFICER_NAME: WEAVER, SALLIE JAYNE

PROJECT_TERMS: Academic Medical Centers;Address;Administrator;Advocate;anti-cancer research;apprenticeship;Cancer Burden;cancer care;Cancer Center;Cancer Control;Cancer Patient;cancer prevention;Cancer Survivor;Cancer Survivorship;care seeking;Caring;Collaborations;Communication;Communities;Community Networks;Comprehensive Cancer Center;Comprehensive Health Care;Country;County;Coupled;Data;Data Reporting;Decision Making;Dedications;design;Diagnosis;Disparity;disparity reduction;Diverse Workforce;early experience;Educational workshop;Ensure;Environment;Equity;evidence base;Evidence based intervention;experience;Goals;Grant;health equity;Healthcare;Holden Comprehensive Cancer Center at the University of Iowa;implementation science;Improve Access;improved;Incidence;innovation;Institution;Interdisciplinary Study;Intervention;Iowa;Lead;Leadership;Letters;Malignant Neoplasms;Medical;meetings;Mentors;Mentorship;Methods;Mission;Modeling;mortality;mortality disparity;network models;next generation;novel;Outcome;parent grant;Parents;patient oriented;Patients;Persons;Policies;Policy Maker;Policy Making;Prevalence;Principal Investigator;Provider;Public Health;Public Policy;Recommendation;Reporting;Research;research data dissemination;Research Personnel;Research Project Grants;Resources;response;Rural;Rural Community;rural patients;Services;skills;success;Supervision;surveillance data;survivorship;Translating;Translational Research;Translations;Travel;United States National Institutes of Health;Work;Writing

PROJECT_TITLE: Adapting Survivorship Care to Rural Practice, Translating Rural Evidence into Policy


NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: CLEVELAND

ORG_DEPT: PSYCHOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The Innovative Mentoring through Professional Advancement and Cultural Training (IMPACT) program is an NIH-funded mentoring program designed to support historically underrepresented students in communication sciences and disorders (CSD). This supplement provides current participating students (undergraduates in CSD and clinical speech-language pathology graduate students) with coaching to help them develop robust professional identities and to develop skills in organization, stress management, time management, and self-sufficiency while adding an online cohort of underrepresented Doctor of Audiology graduate students. The addition of coaching paired with a robust mentoring program will support the retention and success of historically underrepresented groups pursuing clinical and/or research careers in CSD to better serve the growing and diverse population of the United States.

PI_NAMEs: CALANDRUCCIO, LAUREN  (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: academic program;Academic skills;Achievement;Affinity;Audiology;Bachelor's Degree;career;Clinical;cohort;Collaborations;Communication;Communication impairment;Communities;coping;Country;Cultural Backgrounds;Data;design;Development;Dimensions;Disease;Educational Curriculum;Educational process of instructing;Effectiveness;effectiveness evaluation;empowerment;Enrollment;Ensure;experience;Faculty;Feeling;Fostering;Funding;Goals;graduate student;Health;Hearing;Historically Black Colleges and Universities;improved;Individual;innovation;insight;instructor;inter-institutional;interest;Journals;Knowledge;knowledge base;Learning;Life;Master of Science;matriculation;Mentors;Mentorship;Minority;minority student;Modeling;Not Hispanic or Latino;Outcome;parent project;peer;Personal Growth;Persons;Population;Population Heterogeneity;programs;Race;Reporting;Research;Role;Science;Self Efficacy;skill acquisition;skills;social;Speech-Language Pathology;STEM student;stress management;stress reduction;Structure;student participation;Students;success;Target Populations;Time;Time Management;Training;Training Programs;trend;undergraduate student;Underrepresented Populations;Underrepresented Students;United States;United States National Institutes of Health;Universities;Woman;Work

PROJECT_TITLE: “IMPACT: Coaching and Mentoring to Foster the Success of Historically Underrepresented Students in Communication Sciences and Disorders.


ADMINISTERING_IC: EB

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Biomedical Imaging;Networking and Information Technology R&D (NITRD)

ORG_CITY: AUSTIN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: 8. Project Narrative The over-arching theme of this program is to train “comprehensive imaging scientists” in the skills necessary to identify clinically relevant problems and develop techniques to improve the prevention, detection, diagnosis, and treatment of human diseases. Trainees learn the full trajectory of medical imaging, including the application of machine learning methods, and emphasis is placed on experiential learning in clinical environments. The global program outcome is for our students to acquire the skill set needed to improve healthcare through imaging science.

PI_NAMEs: MARKEY, MIA K (contact);RYLANDER, HENRY GRADY

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: imaging informatics;imaging science;Training Programs

PROJECT_TITLE: Comprehensive Training program in Imaging Science and Informatics


ORG_CITY: EUGENE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: Project Narrative Accurate chromosome segregation and repair of DNA breaks during sperm and egg development are essential for preventing infertility, miscarriages, birth defects, and cancer. Developing sperm and eggs accomplish this through specific exchanges of DNA, called recombination events. The proposed research will reveal the mechanisms of these recombination events to increase understanding of fundamental processes critical to human health.

PI_NAMEs: LIBUDA, DIANA ELIZABETH (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Actins;Administrative Supplement;Age;Aging;Aneuploidy;Articulation;Biological Assay;Biological Models;Caenorhabditis elegans;Cell division;Cell Nucleus;Cell Physiology;Cells;ChIP-seq;Chromatin;chromatin immunoprecipitation;Chromosome Segregation;Chromosome Structures;Chromosomes;computational pipelines;Congenital Abnormality;Data;Data Set;Dedications;Defect;defined contribution;Development;DNA;DNA Double Strand Break;DNA Repair;egg;Elderly;Ensure;Event;experimental study;Failure;Female;Fertility;Genetic Crossing Over;Genetic Recombination;Genetic Variation;Genome;genome integrity;Germ Cells;Goals;Haploidy;Health;Heterochromatin;homologous recombination;Human;Image;in vivo;Infertility;Knowledge;male;Malignant Neoplasms;Maternal Age;Meiosis;Meiotic Prophase I;Meiotic Recombination;Mentors;Mentorship;middle age;Mitotic;novel;Oocytes;Outcome;parent project;Pathway interactions;piRNA;polymerization;Polymers;preference;preservation;prevent;Process;programs;Prophase;Proteins;Publications;Publishing;repaired;Research;research study;Resolution;Role;Science;segregation;sex;sexual dimorphism;Sister Chromatid;sperm cell;Spermatocytes;Spontaneous abortion;success;System;Testing;Training;ultra high resolution;whole genome;Work

PROJECT_TITLE: Recombination pathway and partner choices during meiosis


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anorexia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Eating Disorders;Mental Health;Mental Illness;Nutrition;Prevention;Serious Mental Illness;Suicide

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: PROJECT NARRATIVE This project is an administrative supplement to provide support for research staff and equipment. This support will ensure that we reach our recruitment milestones and collect physiological data in a timely fashion. I n turn, this work will help to identify risk factors for the overlap between eating disorders and suicide, which will lead directly to novel prevention and treatment efforts.

PI_NAMEs: LEVINSON, CHERI ALICIA (contact);SMITH, APRIL ROSE

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Acceleration;Administrative Supplement;Agitation;Anorexia Nervosa;Anxiety;Arousal;biological adaptation to stress;Cause of Death;cost;Data;Death Rate;Diagnosis;Dimensions;Eating Disorders;Ecological momentary assessment;emotion dysregulation;emotion regulation;Ensure;Equipment;Feeling suicidal;follow-up;Goals;heart rate variability;high risk population;ideation;Individual;Lead;Mental disorders;mobile computing;novel;Operations Research;Participant;Persons;Physiological;Physiology;Predictive Factor;Prevention;Process;Psychophysiology;recruit;Research Support;Risk;Risk Factors;Science;sensor;severe mental illness;Sleep Wake Cycle;suicidal behavior;suicidal risk;Suicide;suicide rate;Symptoms;Testing;theories;Time;Work

PROJECT_TITLE: Longitudinal Personalized Dynamics Among Anorexia Nervosa Symptoms, Core Dimensions, and Physiology Predicting Suicide Risk

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Diabetes;Nutrition

ORG_CITY: IRVINE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: PROJECT NARRATIVE This study investigates how an immune response to fats contributes to type 2 diabetes. By studying human pancreatic tissue from individuals with and without diabetes, we aim to understand how immune cells damage insulin-producing cells, important for regulating blood sugar. This work will provide new information for development of diabetes treatments and will support underrepresented students in biomedical research.

PI_NAMEs: NICHOLAS, DEQUINA ANGELINA (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: adaptive immune response;Address;Adipose tissue;Analysis of Variance;analysis pipeline;Antigen Presentation;Antigens;Area;Autoantigens;Autopsy;Beta Cell;Biological;Biomedical Research;Black race;Blood Glucose;career;CD1 Antigens;cell injury;Cell Physiology;Cells;Chronic;cohort;Compensation;Coupled;Cytometry;Data;Data Set;Development;Diabetes Mellitus;disadvantaged student;Disease;disease model;Disparity;Endocrine;Environment;experience;Fasting;Fatty acid glycerol esters;Functional disorder;Funding;Generations;Glucose;graduate school;graduate student;High Fat Diet;high throughput screening;Homeostasis;Human;Image;Immune;immune activation;immune cell infiltrate;Immune response;Immunologics;Immunology;In Vitro;in vivo;Individual;Inflammation;insight;Insulin;Insulin Resistance;insulin secretion;islet;Islets of Langerhans;Left;Lipids;Liver;Measures;Mediating;Mentors;Mentorship;Methods;Minority;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Pancreas;parent grant;parent project;Persons;Population;preservation;Production;programs;Qualifying;Research;Research Design;Role;Sampling;Science;Steatohepatitis;Structure of beta Cell of islet;Symptoms;T-Cell Activation;T-Lymphocyte;Testing;Tissues;Training;transfer student;Transgenic Mice;Transgenic Organisms;undergraduate student;Underrepresented Students;unethical;Wild Type Mouse;Work

PROJECT_TITLE: Immune Landscape of Human Pancreatic Islets in Type 2 Diabetes


ADMINISTERING_IC: AT

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Kidney Disease;Physical Activity;Prevention

ORG_CITY: Chicago

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative It is common for adults with end stage kidney disease (ESKD) to experience fatigue, at a level that influences whole person health. With the support of a patient advisory board, this project will develop and test a progressive muscle relaxation and walking intervention to reduce fatigue for adults with ESKD. Results will inform the development of a large-scale trial to reduce fatigue and promote whole person health for adults with ESKD.

PI_NAMEs: HANNAN, MARY  (contact)

PROGRAM_OFFICER_NAME: MUDD, LANAY MARIE

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adult;Affect;arm;attentional control;Behavior Therapy;Behavioral;Behavioral Mechanisms;Chronic Disease;Collaborations;Complex;Data;debilitating symptom;design;Development;Disease;early phase clinical trial;efficacy trial;Employment;End stage renal failure;ethnic minority population;Etiology;Evidence based intervention;exercise intervention;experience;Fatigue;fighting;functional independence;Future;Hemodialysis;improved;innovation;Intervention;intervention delivery;Investigation;Kidney;kidney disease education;Kidney Diseases;Medical;Methods;Mind-Body Intervention;mindfulness;Morbidity - disease rate;mortality;multi-component intervention;Muscle;Muscle relaxation phase;National Center for Complementary and Integrative Health;Output;pain reduction;Participant;Patients;Persons;Physical activity;Physiological;Population;Population Heterogeneity;Populations at Risk;psychologic;Quality of life;racial minority population;Randomized;Randomized, Controlled Trials;recruit;Regimen;Relaxation;Renal Replacement Therapy;Research;Science;social relationships;standard of care;Strategic Planning;Symptoms;telehealth;Testing;Text Messaging;Training;Walking;walking intervention;whole health;Work

PROJECT_TITLE: Fight Fatigue: A progressive muscle relaxation and walking intervention to reduce fatigue in adults with ESKD

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 MQ (01)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE The ventricles of the human brain are lined with ependymal cells projecting numerous whip-like organelles, called motile cilia, which beat in a coordinated fashion to generate fluid flow. Motile cilia beating in the brain is important for proper development and defects in cilia beating are linked to numerous diseases, including hydrocephalus, scoliosis, intellectual disability, mood disorders, Huntington disease, and epilepsy. We are studying the mechanisms that regulate cilia beating in order to understand the functions of motile cilia and how their dysfunction contributes to neurological disorders.

PI_NAMEs: ASKWITH, CANDICE C;MYKYTYN, KIRK A (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Affect;Agonist;Bardet-Biedl Syndrome;base;Behavioral;beta-arrestin;Brain;Cell Line;Cell Physiology;Cells;Cerebrospinal Fluid;cerebrospinal fluid flow;Cilia;cilium motility;Complement;Defect;Development;Disease;Ependyma;Ependymal Cell;Epilepsy;fluid flow;Foundations;Frequencies;Functional disorder;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Genetic Transcription;Health;Human;Huntington Disease;Hydrocephalus;Imaging Techniques;insight;Intellectual functioning disability;Knock-out;Label;Link;Location;MCHR1 gene;Mechanics;Mediating;melanin-concentrating hormone;Membrane;Microscope;Microscopy;Molecular;Molecular Chaperones;Mood Disorders;Movement;Nervous System Disorder;Neuromodulator;Neurotransmitters;novel;Organelles;Outcome;Pathologic;pharmacologic;Physiology;Protein Deficiency;Proteins;Proteome;Proteomics;receptor;Receptor Activation;Receptor Signaling;recruit;Regulation;Resolution;response;Role;scoliosis;Sensory;SHPS-1 protein;Signal Pathway;Signal Transduction;Signaling Protein;Speed;superresolution imaging;System;Techniques;Testing;Therapeutic;tool;Ventricular;Work

PROJECT_TITLE: Elucidating the mechanisms of ependymal ciliary signaling

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE One of the first steps in salient signal detection in cortical structures is the profound activation of dis-inhibitory interneurons expressing vasoactive intestinal polypeptide (VIP). In contrast to the current view, we propose that VIP interneurons can be divided into functionally distinct groups. By combining viral techniques, neuroanatomical methods, in vitro and in vivo electrophysiology, we will determine how distinct, genetically defined types of VIP interneurons respond to aversive signal presentation and reward delivery as well as reveal their target selectivity, the critical parameters underlying circuit mechanisms of salient signal processing in cortical structures.

PI_NAMEs: HAJOS, NORBERT  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Anatomy;Anesthesia procedures;Area;Attention;Attentional deficit;autism spectrum disorder;Aversive Stimulus;awake;Bacterial Artificial Chromosomes;Cells;Cholecystokinin;cognitive process;Coin;Data;Desire for food;Detection;Disinhibition;Electrophysiology (science);Elements;Epilepsy;experimental study;Fire - disasters;foot;frontal lobe;Gene Modified;Goals;Head;Heterogeneity;hippocampal pyramidal neuron;imaging study;In Vitro;in vivo;in vivo imaging;information processing;Interneurons;Learning;Link;Memory;Mental disorders;Methods;Mus;Nervous System;Nervous System Disorder;Neuroanatomy;Neurons;novel;operation;optogenetics;Output;Pathologic;Pattern;Population;postsynaptic;Process;Pyramidal Cells;Reporting;response;Rest;Rewards;Schizophrenia;Shock;signal processing;Signal Transduction;Stimulus;Structure;Techniques;Testing;transcription factor;Transgenic Mice;Vasoactive Intestinal Peptide;Viral;Visual

PROJECT_TITLE: Revealing the complexity of dis-inhibitory circuitries

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: NARRATIVE ASH1L regulates chromatin mediated mechanisms of gene expression by counteracting the activity of the polycomb repressor complex 2. The research goal for this administrative supplement is to define the extent to which the ASH1L/PRC2 axis modulates cell fate transitions and cell type specific gene programs in the developing human brain. In addition, we propose to promote DEI by providing research, scientific writing, scientific communication and career development experiences to trainees from underserved populations at multiple levels (high school, undergraduate, post bac and post-graduate).

PI_NAMEs: LIU, JUDY SHIH-HWA;LIZARRAGA, SOFIA BEATRIZ (contact)

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: Administrative Supplement;Affect;ASH1L gene;autism spectrum disorder;Award;Biomedical Research;Brain;brain cell;career;career development;Cell Lineage;cell type;Cells;Cerebral cortex;Chromatin;Chromatin Remodeling Factor;Communication;Complex;confocal imaging;Critical Thinking;Data;Data Analyses;Defect;derepression;Development;Developmental Gene;Disease;Eligibility Determination;Epigenetic Process;excitatory neuron;experience;Exposure to;FOXP1 gene;Functional disorder;Gene Expression;gene network;gene repression;Genes;Genetic Transcription;Goals;high risk;high school;High School Outreach;Histones;Human;imaging approach;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Intervention;Knowledge;Mediating;Mentors;Mus;Mutation;neurodevelopment;Neurodevelopmental Disorder;neuron development;Neuronal Dysfunction;Neurons;Organoids;Outcome;outreach program;parent grant;Parents;Pathogenesis;Pathogenicity;Patients;Peer Review;Phenotype;Polycomb;Postbaccalaureate;pre-clinical;programs;Publications;Publishing;rare genetic disorder;Repressor Proteins;Research;research and development;response;risk variant;Role;Science;single-cell RNA sequencing;skills;STEM career;Students;summer program;symposium;synaptic function;Technology;Testing;Therapeutic;Training;Training Support;transcription factor;transcriptome;Transferase;translational neuroscience;undergraduate student;Underserved Population;Universities;university student;Variant;Work;Writing

PROJECT_TITLE: ASH1L mediated transcription networks in autism spectrum disorders


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_DEPT: SURGERY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Patients with devastating chronic intestinal failure can survive only with parenteral nutrition delivered through an intravenous catheter. This care is very complex and requires expert physicians operating in multi-disciplinary teams. This project investigates whether intestinal failure patient outcomes can be improved by providing patients and their family caregivers education on best practice care through tele-learning.

PI_NAMEs: IYER, KISHORE R (contact)

PROGRAM_OFFICER_NAME: TERAN, MARIO

PROJECT_TITLE: Patient Intestinal Failure-ECHO Project (PIF-ECHO)

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative The goals of our research are to 1) elucidate the mechanistic link between skin microbiota and local immune dysregulation in rosacea skin and 2) elucidate potential systemic immune dysregulation in rosacea patients. Unlike prior studies, we aim to employ multi-omics data integration to 1) explain the complex relationship of the microbial environment and the host immune response in the skin, and 2) characterize the systemic immune dysregulation that can explain the systemic disease burden in rosacea patients. We anticipate that our findings will lead to the development of novel preventative and therapeutic targets and shift the way we study and manage rosacea toward early detection and prevention of systemic co-morbidities.

PI_NAMEs: MCGEE, JEAN SUH (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Advanced Development;Affect;Atherosclerosis;Bioinformatics;Biological Assay;Biological Response Modifiers;Biometry;Blood;Blood Vessels;burden of illness;cardiovascular risk factor;career;career development;cathelicidin;cathelicidin antimicrobial peptide;Cells;Circulation;Clinical Trials;commensal microbes;Communication;comorbidity;Complex;Computational Biology;Core Facility;Country;cytokine;Data;data integration;Development;Disease;dysbiosis;Early Diagnosis;Educational workshop;Environment;Epidemiology;Epithelium;Etiology;Exclusion;experience;Expression Profiling;Genetic Transcription;Goals;Grant;Health;Homeostasis;host microbiota;Human Subject Research;IL17 gene;Immune;immune activation;Immune response;improved;Inflammatory;Inflammatory Bowel Diseases;Innate Immune Response;Innate Immune System;insight;Institution;interleukin-22;Investigation;Israel;Kininogenase;Link;Mediating;Medical center;medical schools;Mentors;metagenomic sequencing;Microbe;microbial;microbiome;microbiota;Molecular;multidisciplinary;Multiomic Data;multiple omics;new therapeutic target;novel;Outcome;Pathogenesis;Pathway interactions;Patients;Peptides;personalized strategies;Persons;Physicians;Prevention;Principal Investigator;programs;protein expression;Proteome;Proteomics;Protocols documentation;Psoriasis;Public Health Schools;recruit;Regulator Genes;Research;research and development;response;Role;Rosacea;rRNA Genes;Scientist;Serine Protease;Serum;Shotguns;Signal Pathway;Signal Transduction;Skin;skin disorder;skin microbiome;skin microbiota;Stimulus;Systemic disease;Teaching Hospitals;Testing;Therapeutic;therapeutic target;TLR1 gene;TLR2 gene;TNF gene;Training;Transcriptional Activation;transcriptome;transcriptome sequencing;transcriptomics;United States;Whole Blood;Writing

PROJECT_TITLE: Multi-omic Studies of Local and Systemic Immune Dysregulation in Rosacea

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Racial and Ethnic Minority Health Research

ORG_CITY: ATLANTA

ORG_DEPT: PSYCHIATRY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: We propose to examine potential changes in brain oscillatory patterns in response to an intervention that uses breath-synched vibration during breathing meditation to enhance interoception in dissociative trauma-exposed people. We will investigate how change in these oscillatory patterns may be linked to dissociation change as well. We will assess interoception through self-report as well as via neural network response during an interoceptive functional magnetic resonance imaging task.

PI_NAMEs: FANI, NEGAR  (contact);SIEGLE, GREG J

PROGRAM_OFFICER_NAME: QUINLAN, ERIN BURKE

PROJECT_TERMS: Acoustic Stimulation;Address;Affective;Aftercare;Attention;attentional control;Awareness;Behavioral;Biomedical Engineering;Black Populations;Black race;black women;Brain;Breathing;Clinical;Clinical Trials;clinically significant;Cognitive;Collaborations;Collection;Color;Communities;cost effective;cost efficient;Cues;Data;Data Collection;data de-identification;data quality;density;design;Development;Devices;Diagnostic;directed attention;Disabling;Discipline;Dissociation;doctoral student;Electrodes;Electroencephalography;Emotions;Ensure;Exclusion;experience;experimental study;Feedback;Frequencies;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;functional MRI scan;Gel;Goals;Hair;Head;Hybrids;Individual;Interoception;Intervention;Intervention Studies;Link;Magnetic Resonance Imaging;Measures;Medial;medical schools;Meditation;Mentors;Methods;millisecond;mindfulness;mindfulness meditation;Modification;multimodality;neural;neural network;neurophysiology;Neurosciences;Neurosciences Research;novel;Participant;Pathway interactions;Patient Recruitments;Patient Self-Report;Pattern;Persons;Physiological;Pilot Projects;Population;post intervention;Post-Traumatic Stress Disorders;Postdoctoral Fellow;Prefrontal Cortex;Program Sustainability;programs;Protocols documentation;Quality Control;Race;Recovery;recruit;Research;Research Personnel;Respiration;response;response biomarker;Saline;Sampling;Scalp structure;Scientist;Series;Signal Transduction;Skin;source localization;Sternum;stress related disorder;stressor;Structural Racism;sustained attention;System;Texture;Time;Training;training opportunity;Training Programs;Trauma;trauma exposure;Universities;vibration;wearable device;Wood material

PROJECT_TITLE: Electroencephalographic biomarkers of response to vibroacoustically-augmented breath-focused mindfulness

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Behavioral and Social Science;Mental Health

ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE Effective mentorship is a critical component for academic and career development, particularly for trainees underrepresented in the biomedical workforce. The proposed supplement will enhance the program activities of the parent award by providing psychosocial well-being discussions to underrepresented trainees and additional mentor training to provide faculty with practical guidance on how to mitigate racial bias and stereotypes in the context of biomedical research mentorship. These enhancements will impact both the success of our trainees and the long-term, sustained effectiveness of our post-baccalaureate research training program for diversifying the biomedical workforce.

PI_NAMEs: SLY, JAMILIA RAKI;SLY, JAMILIA RAKI (contact);SOBIE, ERIC A

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: anti-racism;Attention;Biomedical Research;Black race;career development;Data;Dedications;Doctor of Philosophy;Education;education research;Educational Curriculum;Educational process of instructing;Educational workshop;Effectiveness;Environment;Ethnic Origin;experience;Faculty;faculty mentor;Goals;graduate student;Healthcare;Hour;Individual;Institution;Lead;maltreatment;Mentors;Mentorship;Outcome;parent project;Participant;Personal Satisfaction;Postbaccalaureate;programs;Psyche structure;psychologic;Psychosocial Assessment and Care;psychosocial wellbeing;Race;racial bias;racism;Recording of previous events;Reporting;Research;research study;Research Training;resilience;Safety;Science;Science, Technology, Engineering and Mathematics Education;Stereotyping;success;Teacher Professional Development;Time;Training;Training Programs;Well in self;Work

PROJECT_TITLE: Postbaccalaureate Research Education Program (PREP)


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cystic Fibrosis;Gene Therapy;Genetics;Human Genome;Lung;Orphan Drug;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative The proposed research will develop the next-generation of high-precision and multiplex base editors to provide an alternative and promising approach for the treatment of human genetic diseases. The advanced base-editing tools will not only greatly benefit the mechanistic study and treatment of cystic fibrosis, an autosomal recessive hereditary disease, but also contribute to other human genetic disorders and fundamental biomedical research.

PI_NAMEs: GAO, XUE  (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Adenine;Affect;airway epithelium;Alleles;autosome;base;base editing;base editor;Bicarbonates;Biomedical Research;Cell Line;Cells;Characteristics;Chlorides;Chronic lung disease;Complex;Computer Assisted;CRISPR/Cas technology;Cystic Fibrosis;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Cytosine;Deaminase;Deamination;Dependence;design;Disease;disease model;DNA;DNA Sequence Alteration;Drug Combinations;drug discovery;efficacy validation;Endonuclease I;Engineering;Epithelial Cells;Exocrine pancreatic insufficiency;flexibility;Functional disorder;gene therapy;Genes;genetic approach;Genetic Diseases;Genome;Genomics;Goals;Guide RNA;Hereditary Disease;Heterozygote;Human Engineering;Human Genetics;Human Genome;improved;individual patient;insertion/deletion mutation;intein;Ion Channel;Length;Lung;Modeling;Mutation;mutation correction;next generation;Nonsense Mutation;nucleobase;Nucleotides;Organ failure;Other Genetics;Outcome;Pancreas;Pathogenicity;Patients;Performance;Pharmaceutical Preparations;pharmacologic;Point Mutation;precise genome editing;premature;prevent;Protein Engineering;Rare Diseases;Regulator Genes;repaired;Research;Resolution;respiratory;reverse genetics;Risk;risk minimization;Safety;Site;small molecule;Somatic Cell;Streptococcus pyogenes;symptomatic improvement;Symptoms;System;Terminator Codon;Therapeutic;therapeutic genome editing;tool;Trans-Splicing;Transfer RNA;transition mutation;Transportation;Variant

PROJECT_TITLE: Develop High-Precision and Multiplex Base Editing Approaches for Therapeutic Applications

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: TOLEDO

ORG_NAME: UNIVERSITY OF TOLEDO

PHR: Narrative: We aim to innovate a cost-effective, high-resolution, high-throughput microscope, versatile in operating across dual modalities to provide both morphological and structural insights, enabling efficient screening of new drugs designed to combat drug-resistant cancers. This groundbreaking technology promises to accelerate the pace of drug discovery, dramatically lowering both the time and costs involved in bringing new cancer treatments to fruition. Furthermore, our innovative portable microscope will empower us to educate and involve a vast number of undergraduate students, particularly those from underrepresented groups, by enabling research and learning opportunities right from the comfort of their own homes.

PI_NAMEs: RAY, ANIRUDDHA  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: Acceleration;African American;Animal Model;anti-cancer research;Antineoplastic Agents;Biochemical;Biological;Biological Assay;Biomedical Engineering;Biomedical Research;cancer cell;Cancer Model;Cancer Patient;cancer therapy;career;caregiving;Cell Death;Cell Death Process;Cells;Chemicals;Collaborations;combat;cost;cost effective;Democracy;design;Development;diversity and inclusion;Drug Design;drug discovery;Drug resistance;Drug Screening;Education;education resources;empowerment;Evaluation;experience;Financial Hardship;Financial Support;Fluorescence;fluorescence imaging;Fluorescence Microscopy;Fostering;Future;Generations;Goals;Grant;hands on research;Health Care Sector;Healthcare;high resolution imaging;Hispanic;Holography;Home;Image;imaging capabilities;imaging modality;in vivo;individual patient;Induction of Apoptosis;innovation;insight;Label;Laboratories;Learning;Microfluidics;Microscope;Microscopy;Minority Groups;minority student;Modality;Modeling;Morphology;mortality;Multi-Drug Resistance;Multimodal Imaging;multimodality;Native Americans;neoplastic cell;Noise;novel;novel anticancer drug;novel therapeutics;organ on a chip;parent grant;parent project;Pathway interactions;personalized medicine;Pharmaceutical Preparations;Phenotype;Physiological;portability;prevent;Principal Investigator;Process;programs;Property;Publications;refractory cancer;Research;Research Personnel;Research Project Grants;Resolution;Resources;response;Sampling;screening;Screening procedure;Signal Pathway;Signal Transduction;skill acquisition;skills;Slide;Students;Techniques;Technology;Therapeutic;Time;timeline;tool;Treatment Failure;treatment strategy;tumor;tumor growth;undergraduate research;undergraduate student;Underrepresented Populations;Underrepresented Students;Visualization;Woman

PROJECT_TITLE: High-throughput high-resolution microscopy for phenotypic drug discovery applications


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Mental Health;Opioid Misuse and Addiction;Opioids;Precision Medicine;Prevention;Substance Misuse

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: While many people experiment with opioids, only a minority undergo the loss of control over drug use that defines opioid use disorder (OUD). The proposed studies will use animal models to characterize changes in gene expression and regulation that confer individual differences in vulnerability at different stages of OUD (for example, initial use, relapse). The results of this research will help develop more effective preventions and treatments for OUD that are tailored to the individual.

PI_NAMEs: GEWIRTZ, JONATHAN  (contact);HARRIS, ANDREW CHARLES

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: Acute;addiction;Addictive Behavior;Anhedonia;Animal Genetics;Animal Model;ATAC-seq;Basic Science;Behavior;Behavioral;behavioral economics;behavioral phenotyping;Bioinformatics;bioinformatics tool;Biological;Biological Assay;ChIP-seq;Chromatin;combinatorial;Consumption;Cues;Data;Data Set;drug reinforcement;Drug usage;Economics;endophenotype;Epigenetic Process;epigenetic regulation;epigenomics;Exhibits;experimental study;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;Exposure to;Extinction;Future;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;genetic variant;Genome;genomic data;genomic locus;Genomics;Genotype;Goals;improved;Impulsivity;indexing;Individual;Individual Differences;individual variation;innovation;Intake;Maps;Measures;Medial;Minority;Modeling;Modification;Molecular Target;Morphine;National Institute of Drug Abuse;next generation sequencing;novel;Opiate Addiction;Opioid;opioid use disorder;Pattern;personalized approach;Persons;Pharmaceutical Preparations;Phase;Phenotype;Play;Predisposition;Prefrontal Cortex;Prevention;Prevention approach;Prevention strategy;prospective;Rattus;Regulation;Regulator Genes;Relapse;Research;Rodent Model;Role;Self Administration;Severities;Sprague-Dawley Rats;System;Techniques;Transcriptional Activation;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Variant;Vulnerable Populations;Withdrawal

PROJECT_TITLE: Identifying genomic loci related to vulnerability to opioid addiction


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: PROJECT NARRATIVE With aging comes a decline in neuronal function and output, as well as increased risk of developing neurodegenerative disorders including Alzheimer’s disease and Parkinson’s disease, however we do not know what it is about the environment of the aging brain that allows these disorders to develop. Astrocytes, glial cells that regulate neuronal function, take on an inflammatory state in the aged brain in a region-specific manner, showing pronounced alterations in motor regions such as cerebellum suggesting these cells may contribute to age-related motor decline. This proposal addresses this by asking if blocking these alterations to astrocytes is beneficial, and what triggers these changes in astrocytes, with a goal of identifying targets to delay age-related neuronal decline in health and in neurodegenerative disorders.

PI_NAMEs: ALLEN, NICOLA J (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Address;Adolescent;Adult;age related;aged;Aging;aging brain;aging related;Alzheimer's Disease;Architecture;Astrocytes;Automobile Driving;Behavior;Behavioral;Biochemical;Blocking Antibodies;Brain;brain cell;Brain region;brain size;Cell Nucleus;Cells;Cerebellum;Cognitive deficits;Corpus striatum structure;Cues;Data Set;Development;Disease;Environment;Enzymes;Excitatory Synapse;experimental study;functional decline;Functional disorder;Future;Gene Expression Profile;gene induction;Genes;genetic manipulation;genetic signature;Genetic Transcription;Goals;Health;Hippocampus;Homeostasis;Human;Hypothalamic structure;Immune system;Immunity;Impaired cognition;Inflammatory;insight;Interferon Receptor;Interferons;Knock-out;Link;Mediating;Metabolic;Microglia;Molecular;Motor;motor deficit;Motor output;Mus;Neurodegenerative Disorders;Neuroglia;Neurons;Neurotransmitters;old mice;Oligodendroglia;Output;overexpression;Parkinson Disease;Pathway interactions;Performance;Peripheral;prevent;Recycling;response;Risk;Risk Factors;RNA delivery;Role;Signal Transduction;Source;Synapses;synaptic function;Techniques;Testing;Tissues;tool;Transcription Alteration;transcription factor;Transcriptional Regulation;transcriptome sequencing;Transgenic Mice;Up-Regulation;Viral;Work

PROJECT_TITLE: Targeting astrocytes to prevent motor decline in aging

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE In South Africa, where 8 million persons are living with HIV, 56% are on ART, and only 45% are virally suppressed (the key indicator of treatment success) due to barriers to care including offering streamlined care only those persons demonstrating treatment success. To address this implementation gap, we propose to test the effect of adaptive differentiated service delivery by offering, in sequence, more tailored services to clients with detectable viral load and those not engaged in care. Working closely with the local HIV clinic, we will leverage ongoing changes in clinic practices to determine the impact of adapting the best clinic practices to include lottery incentives, community ART, and home ART delivery on viral suppression and cost-effectiveness at population level.

PI_NAMEs: BARNABAS, RUANNE VANESSA (contact);VAN HEERDEN, ALASTAIR

PROGRAM_OFFICER_NAME: STIRRATT, MICHAEL JAMES

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;antiretroviral therapy;arm;Back;barrier to care;Behavior;budget impact;care delivery;Caring;Cessation of life;Characteristics;Client;Clinic;Clinic Visits;Communities;cost;Cost Analysis;cost effectiveness;cost estimate;Cost Savings;Disease;Enrollment;Evaluation;experience;follow-up;Frequencies;Friends;Goals;Health Benefit;HIV;HIV Infections;HIV Seronegativity;HIV Seropositivity;Home;improved;incentive strategies;Incentives;Intervention;intervention delivery;Interview;Life;Measures;microcosting;Modeling;Morbidity - disease rate;mortality;Participant;patient-level barriers;peer;Persons;Population;preference;prevent;primary outcome;Provider;Randomized;randomized trial;recruit;Sampling;Sequential Multiple Assignment Randomized Trial;service delivery;Service provision;Services;South Africa;Subgroup;success;System;Testing;transmission process;treatment strategy;trial design;Viral;Viral Load result;Wages;Wait Time

PROJECT_TITLE: A sequential, adaptive model of differentiated service delivery to reach persons living with HIV who are lost-to-follow-up or who have detectable viral load

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE FROM PARENT GRANT Guaranteed Basic Income (GBI) could address deep systemic social and structural inequities that lead to health disparities in Black youth, with potential to improve the financial, mental and physical well-being of Black emerging adults during their critical period of transition to independence. This study includes implementation and evaluation of an innovative, multilevel intervention to address grave inequities in health by providing GBI and access to financial coaching, peer-support, and real-time monitoring of needs and referral to services. The project will provide critical data needed to understand the potential of GBI for Black youth and how to maximize its impact on health with targeted programming at a time when multiple municipalities are considering GBI legislation.

PI_NAMEs: LIBBY, MARGARET ;LIGHTFOOT, MARGUERITA A.;LIPPMAN, SHERI ANN (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Acceleration;Address;Administrative Supplement;Adult;Affect;Age;Anxiety;arm;behavioral and social science;Black race;career;career development;career networking;Cellular Phone;Cities;Clinical Research;Communities;community partners;Complex;Coupled;critical period;Cross-Over Trials;Data;Data Analyses;Data Collection;depressive symptoms;design;Development;Development Plans;Discrimination;economic evaluation;Economic Models;Economics;Education;Effectiveness;emerging adult;Employment;Enrollment;Ensure;Environment;Equity;equity, diversity, and inclusion;Evaluation;experience;Exposure to;Family;Family Planning;follow-up;Future;Grant;Health;Health Disparities Research;health disparity;health equity;health inequalities;Health Services Needs;human capital;improved;Income;Individual;Inequity;innovation;insight;interest;Intervention;Investments;Low income;Manuscripts;Measures;Mental Health;Mental Health Services;Mentors;Mentorship;Modeling;Monitor;multidisciplinary;Municipalities;next generation;novel;Outcome;outcome disparities;parent grant;Parents;Participant;peer learning;peer support;Personal Satisfaction;Phase;physical conditioning;Play;Policies;Policy Maker;Population;Positioning Attribute;Poverty;Professional Competence;programs;Psyche structure;Randomized;real time monitoring;Reduce health disparities;Research;Research Activity;Research Personnel;Research Project Grants;Resources;response;Role;Scientist;service gap;Service provision;service utilization;Services;sexual and reproductive health;skills;social;social capital;social determinants;Statutes and Laws;Structure;System;Talents;Technical Expertise;Time;Training;transition to adulthood;Work;working group;Writing;young adult;Youth

PROJECT_TITLE: Increasing financial and health equity among low income black youth and young adults - DEIA Supplement

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(50)-R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative We propose that reciprocal changes between microglia and neurons during early stages of tauopathy contribute to disease progression. To investigate, we will integrate microglia, MAPT mutations, and iPSC-derived hippocampal and ganglionic eminence fusions with robust circuits.

PI_NAMEs: REXACH, JESSICA E (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Affect;Alzheimer's Disease;Alzheimer's disease model;Biosensor;Brain;Calcium;cell type;Coculture Techniques;comparative;Complex;cytokine;Data;Defect;Development;Disease;Disease Progression;Electrophysiology (science);excitatory neuron;Exhibits;experimental study;Foundations;Functional disorder;Ganglia;Genetic;Genetic Markers;Hippocampus;hyperphosphorylated tau;Image;Immunohistochemistry;Implant;Induced Mutation;induced pluripotent stem cell;Inflammatory;Inflammatory Response;inhibitory neuron;insight;Location;Microglia;Modeling;mutant;Mutation;Nerve Degeneration;neural;neural network;Neurodegenerative Disorders;neuron loss;neuronal circuitry;Neuronal Dysfunction;Neurons;Organoids;overexpression;Parvalbumins;Pathology;patient derived induced pluripotent stem cells;Pattern;Phagocytes;Phenotype;Physiology;Play;Property;Proteins;PTPNS1 gene;Regulation;Research;response;Role;Signal Pathway;Somatostatin;Synapses;tau mutation;tau Proteins;Tauopathies;Toxic effect;transcriptomics;two-photon;Western Blotting

PROJECT_TITLE: Probing the Toxic Effects of Early Stage Tau Pathology on Microglial Modulation of Neuronal Circuits Using iPSC Hippocampal Assembloids

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Z (55)]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: SAN DIEGO

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: OVERALL – Project Narrative San Diego State University (SDSU) is proposing a new faculty recruitment and retention program called SDSU FUERTE (Faculty Unified towards Excellence in Research and Transformational Engagement). Utilizing innovative, evidence-based strategies to promote institutional inclusive excellence, SDSU will recruit nine early-stage, interdisciplinary, tenure-track researchers who have career goals to address Latinx health disparities in the areas of Addiction Science, Environment Health, and Obesity/Physical Activity/Nutrition.

PI_NAMEs: REED, MARK BRIAN;ZUNIGA DE NUNCIO, MARIA LUISA (contact)

PROGRAM_OFFICER_NAME: HUSSAIN, SHADAB FATIMA

PROJECT_TERMS: Academy;Acceleration;addiction;Address;Affect;Area;Biomedical Research;career;career development;Climate;cohort;Communities;community building;community engaged research;community engagement;design;Development;Development Plans;Discrimination;Disparity;Diverse Workforce;early-career faculty;Educational Curriculum;Eligibility Determination;Environment;Environmental Health;equity, diversity, and inclusion;Evaluation;evidence base;experience;Faculty;Faculty Recruitment;faculty support;Funding;Goals;Grant;Growth;Health;health disparity;health science research;Health Sciences;Hispanic-serving Institution;Human;implementation science;improved;Individual;innovation;Institution;Institutionalization;interest;Knowledge;Latinx;Leadership;Mentors;Mentorship;Minority;Minority Groups;model development;Modeling;nutrition;Obesity;Peer Review;Personal Satisfaction;Persons;Physical activity;Positioning Attribute;programs;recruit;Research;Research Personnel;Resources;Scholarship;Schools;Science;Scientific Advances and Accomplishments;Secondary Schools;Secure;skills;Students;success;Teacher Professional Development;tenure track;Training;Underrepresented Minority;United States;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: SDSU FUERTE: Recognition of Excellence in DEIA and Mentorship in support of Faculty Success

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(51)-R]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Physical Rehabilitation;Rehabilitation

PHR: PARENT PROJECT NARRATIVE Speech deficits are among the most prevalent and impairing of clinical features for individuals with Autism Spectrum Disorder (ASD), yet the specific barriers to speech production are poorly understood, and consequently, the existing treatments do not target the source of the problem. The objective of this study is to characterize the specific processes in the speech motor system in participants with ASD in order to understand the factors that lead to impaired speech. The long-term goal is to identify new directions for novel approaches to treatment that target the specific barriers to speech for individuals with ASD.

PI_NAMEs: DEMOPOULOS, CARLY  (contact);LI, YAN

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Address;Administrative Supplement;Adolescent;Age;aged;Area;Assessment tool;auditory feedback;Autism diagnostic;autism diagnostic observation schedule;autism spectrum disorder;autistic children;Behavioral;Brain;Brain imaging;Caliber;career;Chemicals;Child;Clinical;Clinical Psychology;Clinical Research;Clinical Services;Code;Communication impairment;Communities;Competence;Dedications;Development;Diagnosis;Diagnostic;Diagnostic Services;disability;doctoral student;Educational process of instructing;Enrollment;equity, diversity, and inclusion;Evaluation;experience;Exposure to;Failure;Feedback;Fostering;Functional Magnetic Resonance Imaging;Future;Goals;Health Services Accessibility;Healthcare;Hour;Impairment;Individual;individuals with autism spectrum disorder;interest;International;Intervention;Interview;Learning;lectures;Magnetic Resonance Spectroscopy;Magnetoencephalography;Mentors;Mentorship;Methods;minimally verbal;Motor;motor control;motor impairment;MRI Scans;neural;Neuroanatomy;neuromechanism;Neuropsychology;Newly Diagnosed;novel;novel strategies;Outcome;parent project;Participant;Peer Review;Population;pre-doctoral;Prevalence;Procedures;Process;Production;Prognosis;programs;Psychologist;Psychophysics;Recording of previous events;Recruitment Activity;Reporting;Research;Research Activity;Research Peer Review;Research Project Grants;service gap;service providers;skills;social group;Socialization;Source;Speech;Speech Therapy;Students;success;Supervision;symposium;Symptoms;System;Testing;Time;tool;Training;training opportunity;Training Programs;Translating;Video Recording;Waiting Lists;webinar;Work;Writing

PROJECT_TITLE: Administrative Supplements to Recognize Excellence in Diversity, Equity, Inclusion, and Accessibility (DEIA) Mentorship to Neural mechanisms of speech motor control in Autism Spectrum Disorders

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ORG_CITY: TUCSON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ARIZONA

PHR: Project Narrative: Elimination of glucagon receptor signaling shortens lifespan and healthspan in mice. Preliminary data presented in this proposal suggests that increasing glucagon signaling can improve metabolic and physical function in aging mice. Herein, we propose to extend these preliminary findings to investigate the potential to enhance glucagon signaling to extend healthspan and lifespan.

PI_NAMEs: STERN, JENNIFER HELENE (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: 5'-AMP-activated protein kinase;adenovirus mediated delivery;Adenylate Cyclase;adenylate kinase;Affect;age acceleration;age-related disease;Aging;aging mechanism;Agonist;Behavior Therapy;blood glucose regulation;Caloric Restriction;Cells;cerebrovascular;Chronic;Clinic;Cognitive;cognitive function;constitutive expression;Cyclic AMP;Data;detection of nutrient;Development;Diabetes Mellitus;Diet;diet-induced obesity;dietary;Energy Metabolism;extend lifespan;gene therapy;Genetic;Genetic Models;Glucagon;Glucagon Receptor;glucagon-like peptide 1;hallmarks of aging;healthspan;Hepatic;Hepatocyte;High Fat Diet;Hormones;hyperglucagonemia;Impairment;improved;Insulin;insulin signaling;Intervention;Knock-out;Knockout Mice;life span;Liver;Longevity;Marketing;Mediator;Metabolic;Mitochondria;Modeling;Molecular;Mus;mutant;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;normal aging;Obese Mice;Obesity;Pathway interactions;Persons;Pharmaceutical Preparations;pharmacologic;Physical Function;Play;prevent;proteostasis;Receptor Activation;Receptor Signaling;Research;Research Personnel;Rodent;Role;senescence;Serum;Signal Pathway;Signal Transduction;Skeletal Muscle;Telomere Shortening;Therapeutic;Thinness;Tissues;Translating;treatment response;Type 2 diabetic;Weight;Wild Type Mouse;Work

PROJECT_TITLE: Investigating the Role of Hepatic Glucagon Receptor Signaling in Healthspan and Aging

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences

PHR: Anxiety disorders are characterized by problems learning about potentially dangerous situations, particularly when possible outcomes in a situation are uncertain. The present application proposes to use neural and computational approaches to understand why people high in anxiety have difficulties learning about uncertainty and why uncertain situations are avoided in and outside of the laboratory. The goal of this application is to determine what learning difficulties are present in anxiety in order to develop more effective treatments that target these learning difficulties.

PI_NAMEs: BROWN, VANESSA  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Anxiety;Anxiety Disorders;anxiety treatment;anxious;Arousal;Association Learning;avoidance behavior;Behavior;Behavior assessment;behavior measurement;Behavioral;Brain;career;Clinical;clinical predictors;clinically relevant;Complex;computer framework;Computer Models;Dangerousness;depressive symptoms;Diagnosis;Diagnostic;Disease;Ecological momentary assessment;effective therapy;experience;Fright;Functional Magnetic Resonance Imaging;functional MRI scan;Future;Goals;Impairment;improved;Individual Differences;individual variation;Interview;Laboratories;Learning;Learning Difficulty;Link;Maps;Measures;Mental disorders;Mentors;Modeling;National Institute of Mental Health;neural;Neurobiology;neuroimaging;neuromechanism;novel;Outcome;Participant;Patient Recruitments;Performance;Persons;Play;prevent;Process;Psychiatry;Psychologist;Questionnaires;remediation;Reporting;Research;response;Role;Sampling;Scientist;Signal Transduction;Specificity;Stimulus;Symptoms;Task Performances;Testing;theories;tool;Training;Training Activity;Uncertainty;Universities;Update;Visit

PROJECT_TITLE: Neurocomputational substrates of maladaptive uncertainty learning and avoidance in anxiety


ED_INST_TYPE: SCHOOLS OF NUTRITION

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Childhood Obesity;Clinical Research;Genetics;Microbiome;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: LINCOLN

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: PROJECT NARRATIVE Obesity and its co-morbidities are major threats to the health of the U.S. public, and the 20% prevalence in children and adolescents is alarming (15 million children and adolescents). This administrative supplement draws expertise from four NIH IDeA states to decrease the prevalence of childhood obesity using a new technologically and economically feasible approach that involves preservation of extracellular vesicles in milk that is frozen for storage.

PI_NAMEs: ZEMPLENI, JANOS  (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: absorption;Administrative Supplement;Adolescent;Archives;Arkansas;Award;Bacteria;bacterial community;Bifidobacterium;Biological Availability;Breastfed infant;career;Cell Communication;Cell model;Cells;Centers of Research Excellence;Child;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;community research;comorbidity;Computational Biology;Consumption;Core Facility;Crystal Formation;Data;Development;Diet;dietary;Dietary intake;Disease;Educational workshop;Energy Metabolism;Energy Metabolism Pathway;Enteral;Environment;Equipment;Eukaryota;Evolution;Exclusive Breastfeeding;exosome;Experimental Designs;extracellular vesicles;Feces;Food;Freezing;Funding;Future;gastrointestinal epithelium;Genes;Genetic Models;genetic selection;Genetic Transcription;genetic variant;Genomics;Glucose;glucose metabolism;Goals;Grant;gut bacteria;gut microbiome;Health;Home;Homeostasis;Human Milk;Human Resources;Ice;Infant;infant gut microbiome;Infant Health;Inflammatory Response;innovation;innovative technologies;instrumentation;Intake;Kansas;Lead;Learning;Mass Spectrum Analysis;Medical;Medical center;Memory;Mentors;Messenger RNA;metabolomics;Metagenomics;Methodology;Milk;Milk Banks;milk intake;Mission;Molecular;multidisciplinary;Mus;NADP;National Institute of Diabetes and Digestive and Kidney Diseases;Nebraska;neonate;Nevada;new technology;novel;nutrition;Nutritional;Obesity;obesity in children;obesity prevention;Oral;Oral Administration;Paper;parent project;Parents;pasteurization;Pathway interactions;Performance;Persons;Phase;Phenotype;preservation;Prevalence;prevent;Principal Investigator;programs;Proteomics;Protocols documentation;Publishing;Purines;Recommendation;recruit;Reporting;repository;Research;Research Personnel;RNA;sample archive;Sampling;Science;Scientist;sensor;Services;Shotguns;Source;Structure;success;sugar;symbiont;Technology;Testing;transcriptome sequencing;Translational Research;United States;United States National Institutes of Health;Universities;Variant;Veterans;Visit;Weaning

PROJECT_TITLE: Nebraska Center for the Prevention of Obesity Diseases through Dietary Molecules


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Mental Health;Neurosciences

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative Brains are composed of many continually interacting regions, and processes such as cognition and behavior are the result of those interactions. But understanding multi-region interactions requires studying many brain regions simultaneously, which is difficult to do at single-cell resolution. Here we propose to develop electrophysiological recordings from many thousands of neurons distributed across tens of brain regions simultaneously, and to develop new modeling approaches and analysis tools for the resulting data, with the goal of understanding how networks of neurons across many regions give rise to decision-making behaviors.

PI_NAMEs: BRODY, CARLOS D (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: Address;Animals;Architecture;Behavior;Brain;Brain region;Cells;Chronic;Cognition;Communication;Computer Models;cost effective;Data;Data Set;Decision Making;Development;Electrophysiology (science);experience;experimental study;Goals;Head;Implant;improved;Individual;Joints;Knowledge;Measures;Methods;Modeling;Motor;neural;neural circuit;Neurons;next generation;optical fiber;Pattern;Population;Privatization;Process;Rattus;Resolution;Rewards;Sensory;sensory stimulus;Signal Transduction;superior colliculus Corpora quadrigemina;Testing;Time;tool;Training

PROJECT_TITLE: Cross-brain, multi-region interactions in decision formation and decision commitment

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


NIH_SPENDING_CATS: Burden of Illness;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Lymphatic Research;Lymphoma;Racial and Ethnic Minority Health Research;Rare Diseases;Rural Health;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE NHL is the most common hematologic malignancy, and there are many unmet clinical and public health needs of this growing patient population. The goal of this infrastructure grant is to support a cohort of over 16,000 non-Hodgkin lymphoma (NHL) patients in order to address broad and cutting-edge research that identifies clinical, epidemiologic (including lifestyle and other exposures), host genetic, tumor, and treatment factors, and the interaction among these factors, on short and long-term outcomes. The efforts of this Supplement are well aligned with the ultimate goal of identifying new approaches to improve the survival and well-being of NHL patients.

PI_NAMEs: CERHAN, JAMES R (contact);FLOWERS, CHRISTOPHER R

PROGRAM_OFFICER_NAME: SHELBURNE, NONNIEKAYE F

PROJECT_TERMS: Address;Adolescent and Young Adult;African American;Age;Asian;Automobile Driving;biobank;Biometry;Blood specimen;Cause of Death;Clinic;Clinical;Clinical Data;Clinical Research;Clinical Trials Network;cohort;Cohort Studies;Data;Decision Making;Development;Diagnosis;digital pathology;Disease Progression;DNA;Electronic Health Record;Enrollment;Environmental Exposure;Epidemiology;epidemiology study;Ethnic Origin;follow-up;Formalin;Genetic;Germ Lines;Goals;Grant;Growth;Health;Hematologic Neoplasms;Hispanic;improved;Incidence;Indolent;Informatics;Infrastructure;International;Life Style;Lymphoma;Malignant Neoplasms;Minority Groups;Newly Diagnosed;Non-Hodgkin's Lymphoma;non-Hodgkin's lymphoma patients;novel;novel strategies;older adult;Outcome;Paraffin Embedding;Participant;Pathology;pathology imaging;patient advocacy group;Patient Outcomes Assessments;patient population;Patients;peripheral blood;Personal Satisfaction;Persons;Plasma;Population;Prognosis;prospective;public database;Public Health;Race;recruit;Relapse;Research;Research Personnel;Research Priority;Research Project Grants;Resources;Retreatment;RNA;rural patients;Rural Population;Sample Size;Second Primary Cancers;Serum;Slide;Socioeconomic Factors;Survival Rate;Survivors;survivorship;Tissue Microarray;Tissue Sample;Translations;Treatment Factor;treatment strategy;trend;tumor;Tumor Bank;tumor DNA;Update

PROJECT_TITLE: The Lymphoma Epidemiology of Outcomes (LEO) Cohort Study (Diversity Supplement - Mazie Tsang)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cardiovascular;Clinical Research;Neurosciences

PHR: NARRATIVE Increased arterial stiffness has been associated with indicators of damage to the brain including presence of white matter hyperintensity, infarctions, brain atrophy as assessed with magnetic resonance imaging (MRI). Ultrasound is a first-line imaging modality for evaluation of vascular geometry and flow because of its real-time capabilities, but many scanners do not have the capabilities to measure arterial mechanical properties in an accurate, quantitative manner. Successful completion of this project will characterize the relationship between ultrasound-based measurement of carotid artery mechanical properties and MRI measured indicators of brain health.

PI_NAMEs: URBAN, MATTHEW WILLIAM (contact)

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: absorption;Acoustics;Address;arterial stiffness;Arteries;Blood Vessels;Brain;brain health;brain morphology;brain tissue;Cardiovascular system;Carotid Arteries;cerebral atrophy;Classification;Clinic;Clinical;Computer Models;Data;data reduction;disease classification;Elasticity;Engineering;Evaluation;Frequencies;Geometry;Grant;imaging modality;improved;Infarction;Magnetic Resonance Imaging;mathematical model;Measurement;Measures;mechanical properties;Mechanics;Medicine;Methods;Modeling;Motion;Noise;Patients;predictive tools;Property;Pulsatile Flow;Radiation;Radiology Specialty;Research;Research Project Grants;Signal Transduction;Techniques;temporal measurement;Time;Translations;transmission process;ultrasound;viscoelasticity;waveguide;White Matter Hyperintensity

PROJECT_TITLE: Diversity Supplement: Measuring arterial material properties using wave-based approaches with ultrasound and computational models

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Aging;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Natural Products;Osteoporosis

ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

PHR: Project Narrative This project is relevant to public health in that it will elucidate the mechanism of age-associated alveolar bone loss in periodontal disease and propose new therapeutics for the disease. Outcomes from the project will add a new alternative treatment strategy to conventional treatment to prevent tooth loss by periodontal disease. Furthermore, the outcomes will be a foundation to develop a new public health strategy for the prevention of tooth loss.

PI_NAMEs: KITTAKA, MIZUHO  (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Address;Adult;Adverse effects;Age;age related;Age-Related Bone Loss;age-related disease;Aging;alternative treatment;alveolar bone;Alveolar Bone Loss;Attenuated;Biological;Biological Assay;Biology;bone;bone loss;Bone Resorption;Cell Aging;Cells;clinical efficacy;Clinical Trials;conventional therapy;Development;Disease;disease model;Excision;experimental study;fisetin;Foundations;Future;Genes;Genetic Markers;Gingiva;Goals;Human;Immunohistochemistry;improved;Induction of Apoptosis;Inflammation;Life;Ligature;Mandible;Mature Bone;Measurement;Mechanics;Mediator;Mus;Musculoskeletal;novel therapeutics;old mice;Osteoclasts;Osteogenesis;Outcome;Outcome Study;Pathologic;Pathology;Patients;Periodontal Diseases;Periodontal Ligament;Pharmaceutical Preparations;phenotypic biomarker;Play;Predisposition;Prevalence;prevent;Prevention strategy;Public Health;Recovery;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;stressor;telomere;Testing;Therapeutic Intervention;therapeutically effective;Tissues;Tooth Cervix;Tooth Loss;Tooth structure;treatment strategy;Work

PROJECT_TITLE: The role of cellular senescence in bone loss and recovery in periodontal disease

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Narrative Traumatic brain injury (TBI) is a severe health issue that, in older populations, increases the risks of dementia. The proposed study aims to develop potential novel therapeutic strategies targeting previously unexplored immune cells and reducing post-TBI cognitive decline, particularly in aging populations.

PI_NAMEs: KANO, SHINICHI  (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Affect;age effect;age related;Aging;aging related;Algorithms;Antibodies;Award;Brain;Brain Injuries;Cells;Cognitive;cognitive recovery;Complex;Data;Data Analyses;dementia risk;experimental analysis;Flow Cytometry;Functional disorder;glial activation;Health;Immune;Immunohistochemistry;Impaired cognition;Injury;injury recovery;insight;Investigation;Methods;neuroimmunology;neuroinflammation;neutrophil;Neutrophil Infiltration;novel therapeutic intervention;Older Population;Pathology;Population;Research Personnel;Research Training;response;Role;Signal Transduction;single-cell RNA sequencing;skills;tau Proteins;Techniques;Thalamic structure;Training;Traumatic Brain Injury;Validation

PROJECT_TITLE: Influence of thalamic IL-33 signaling in aging-associated exacerbation of cognitive impairment after brain injury via microglial dysfunction and tau pathology