ORG_CITY: BIRMINGHAM

ORG_NAME: BIRMINGHAM VA MEDICAL CENTER

ORG_STATE: AL

PHR: The National Call Center for Homeless Veterans (NCCHV) responds to more than 100,000 contacts annually from Veterans who are currently experiencing or at imminent risk of homelessness—an important social determinant of health—and others calling on their behalf. While the U.S. Department of Veterans Affairs (VA) has implemented and evaluated an array of primary, secondary, and tertiary interventions t o prevent and end homelessness among Veterans—resulting in a significant reduction in Veteran homelessness—this important “front door” to services has not been studied. This study will comprehensively examine how NCCHV connects, triages, and links Veterans to needed services and their resulting housing, service use, and mortality outcomes.

PI_NAMEs: MONTGOMERY, ANN ELIZABETH (contact);TSAI, JACK

PROJECT_TERMS: Address;Age;care preference;Caring;Characteristics;Clinical;Communities;connected care;COVID-19 pandemic;Data;Data Analyses;Data Sources;design;Documentation;Electronic Health Record;Eligibility Determination;Emergency Situation;Ensure;experience;Family;Family member;Funding;Future;Gender;health care availability;health equity;Health Services Accessibility;Healthcare;Homelessness;Hour;Housing;housing instability;Human;Improve Access;Income;indicated prevention;Individual;informant;innovation;Intervention;Interview;Leadership;Learning;Link;Literature;Methodology;Methods;military veteran;mortality;Online Systems;operation;Outcome;Outpatients;prevent;Prevention;Primary Prevention;programs;Provider;Public Health;Qualitative Methods;Reporting;Research;Resources;response;Risk;satisfaction;screening;Secondary Prevention;selective prevention;Services;Shelter facility;social health determinants;sociodemographics;structured data;supported housing;telehealth;Telephone;tertiary prevention;Testing;Time;Training;Triage;U.S. Department of Housing and Urban Development;Unemployment;United States Department of Veterans Affairs;universal prevention;Veterans;virtual healthcare

PROJECT_TITLE: Keeping the front door open: Preventing homelessness through the National Call Center for Homeless Veterans


ADMINISTERING_IC: VA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: WEST HAVEN

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VA CONNECTICUT HEALTHCARE SYSTEM

ORG_STATE: CT

PHR: PROJECT NARRATIVE Insomnia is a common and serious health condition associated with suicide and poor quality of life. Although cognitive behavioral therapy for insomnia (CBTi) is the gold-standard for care, few Veterans receive this treatment due to a host of barriers. The VA has developed a Veteran-oriented online version of CBTi called Path to Better Sleep (PTBS), which is free and available to all Veterans. PTBS has been widely advertised throughout the VA and Veteran service organizations. However, use of PTBS has been only modest. Prior research has shown that patients are more likely to participate in online treatments when supported by coaches. In addition, PTBS must be integrated into VA clinical workflow. The objective of this research is to evaluate the effectiveness of a coached version of PTBS and a scalable strategy for implementing Coached PTBS in VA care called Replicating Effective Programs for Digital Interventions (REP-DI). If effective, Coached PTBS implemented with REP-DI could expand Veteran access to insomnia treatment.

PI_NAMEs: HERMES, ERIC  (contact);ULMER, CHRISTI S

PROJECT_TERMS: Address;Adherence;Adoption;Affect;Caring;Clinic;Clinical;Clinical effectiveness;Clinical Practice Guideline;Clinical Trials Network;Cognitive Therapy;connected care;Consolidated Framework for Implementation Research;Data;Data Security;design;diaries;digital;digital intervention;disorder prevention;Effectiveness;effectiveness evaluation;effectiveness trial;Elements;Evaluation;evidence base;Exposure to;Fatigue;formative assessment;Functional impairment;gaps in access;Guidelines;Health;Health Promotion;Healthcare Systems;Hybrids;hypnotic;implementation evaluation;implementation intervention;implementation outcomes;implementation strategy;implementation/effectiveness;improved;improvement on sleep;Individual;innovation;Internet;Interview;K-Series Research Career Programs;Literature;Maintenance;Measures;Medical;Mental disorders;Mental Health;Methodology;Methods;military veteran;Modality;Modeling;Mood Disorders;Moods;Morbidity - disease rate;online version;Outcome;Outpatients;pandemic disease;patient engagement;Patients;Pharmaceutical Preparations;Post-Traumatic Stress Disorders;Prevalence;Principal Investigator;Process;programs;Provider;Publishing;Qualitative Methods;Quality of life;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Replicating Effective Programs;Reporting;Research;Resource-limited setting;Resources;Risk;Rural;rural area;rural healthcare;rural setting;Schedule;sedative;Self Care;Self Management;self-management program;service organization;Services;Severities;Site;Sleep;Sleeplessness;social stigma;standard care;Stimulus;Suicide;Symptoms;System;Testing;Time;Training;Travel;treatment as usual;Veterans;virtual coach;Visit;Work

PROJECT_TITLE: Path To Better Sleep + Virtual Coaching: The Effectiveness and Implementation of Internet-Based Self-Management Program for Insomnia in a Regional Healthcare System

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


ORG_CITY: SAN FRANCISCO

ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

ORG_STATE: CA

PHR: Asynchronous or store-and-forward teledermatology is an important pathway for increasing Veterans’ access to expert skin care. It is not clear, however, that access consistently translates into clinical outcomes that are comparable to usual in-person care. This project uses a form of artificial intelligence known as natural language processing (NLP) to learn how key clinicians document skin disease, and to analyze patients’ medical records to compare outcomes for five common but significant skin diseases that have been managed by either teledermatology or by usual in-person care. The results will be the first systematic application of NLP to assess telehealth outcomes, may identify areas to remedy and to strengthen VA’s teledermatology and telehealth programs, and may suggest enterprise-wide approaches to enable clinicians and staff to monitor and improve teledermatology and dermatology outcomes in Veteran patients.

PI_NAMEs: OH, DENNIS H (contact)

PROJECT_TERMS: Acceleration;Adopted;Area;Artificial Intelligence;Calibration;Caring;Catalogs;Categories;Clinical;clinical outcome measures;clinically significant;Communication;Computerized Medical Record;Consult;Consultations;dashboard;Data;data warehouse;Dermatologic;Dermatologist;Dermatology;Development;Diagnosis;Diagnostic;Diagnostic Procedure;Distant;Eczema;Effectiveness;Electronic Health Record;Event;follow-up;forest;Healthcare Systems;improved;innovation;Language;Learning;Machine Learning;Manuals;Measures;Medical Records;Methodology;Methods;Modeling;Monitor;Natural Language Processing;novel;Outcome;Outcome Measure;Outcomes Research;Output;Pathway interactions;patient health information;patient safety;Patients;Performance;Persons;Policies;primary care clinic;primary care provider;Process;programs;Provider;Proxy;Psoriasis;Quality of Care;Recommendation;relative effectiveness;response;Rural Community;Safety;San Francisco;Services;Skin;Skin Care;skin disorder;Skin Neoplasms;structured data;Surveys;System;teledermatology;telehealth;Testing;Text;Therapeutic procedure;tool;Training;training data;Translating;treatment as usual;Triage;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Clinical outcomes for asynchronous teledermatology

STUDY_SECTION_NAME: HSR-3 Healthcare Informatics[HSR3]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Clinical Research;Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Lesions or dysfunction in the supplementary motor area can cause deficits in fluent speech seen in patients with stuttering or after resection of brain tumors. We aim to study this process using intracranial electrodes in epilepsy patients to better understand speech production and treat language dysfunction in these patients.

PI_NAMEs: MALLELA, ARKA NARAYANA (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: adjudication;Area;Articulation;awake;Basal Ganglia;Brain Mapping;Brain Stem;brain tumor resection;Callithrix;Chronic;clinical practice;Communication;Developmental Stuttering;Diffusion;Dimensions;Disease;Disfluent;Electrodes;Electroencephalography;Electrophysiology (science);Elements;Epilepsy;Evoked Potentials;experience;Fellowship;Fingers;Functional disorder;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Generations;Goals;Hand;Human;human subject;Image;Implant;improved;Inferior frontal gyrus;innovation;Language;Language Disorders;Lesion;lexical;Literature;Macaca;Medial;Modeling;Motor;Motor Cortex;motor deficit;Movement;multidisciplinary;Neuroanatomy;neurophysiology;Neuropsychological Tests;Neuropsychology;Neurosurgeon;nonhuman primate;Output;Pathway interactions;Patients;Pattern;phonology;Process;Production;programs;Psycholinguistics;Reporting;Research;Role;Scientist;Semantics;Specific qualifier value;Speech;Speech Disorders;Spinal Cord;Structure;Structure of middle temporal gyrus;Stuttering;Syndrome;System;temporal measurement;Testing;Thalamic structure;Training;Translating;transmission process;vocalization;Work

PROJECT_TITLE: Exploring the expressive language function of the supplementary motor area


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative The proposed research is relevant to public health because it will not only reveal critical molecular insights into the role of ARID1A mutation in cancer and particularly ovarian cancer, but also provide a scientific rationale for developing urgently needed new pre-clinical therapeutic strategies for this disease. These studies will also serve as a prototype for other epigenetic therapeutic strategies for cancers with genetic alterations in other regulators of chromatin structure, a well-recognized feature of many cancer types. Therefore, the proposed research is relevant to NIH’s mission in terms of developing fundamental knowledge that will reduce the burden of human illness.

PI_NAMEs: ZHANG, RUGANG  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: 3-Dimensional;Acetylation;Apoptosis;Apoptotic;ARID1A gene;cancer cell;cancer subtypes;cancer type;Catalytic Domain;Cells;chemotherapy;chromatin remodeling;Chromatin Remodeling Factor;Chromatin Structure;Clinical;clinical application;clinically relevant;combinatorial;Data;Deacetylation;Dependence;Diagnosis;Disease;Down-Regulation;effective therapy;Epigenetic Process;Epithelial ovarian cancer;experimental study;EZH2 gene;feature detection;Gene Expression;gene repression;Genes;Genetic;genetic makeup;Goals;HDAC6 gene;Human;inhibitor;innovation;insight;Intervention;Knowledge;LoxP-flanked allele;Lysine;Malignant neoplasm of ovary;Malignant Neoplasms;Methods;Mission;Modality;Molecular;mouse model;Mutate;Mutation;novel;Outcome;Ovarian Clear Cell Tumor;Ovarian Endometrioid Adenocarcinoma;patient derived xenograft model;Platinum;Post-Translational Protein Processing;pre-clinical;Pre-Clinical Model;precision medicine;Primary Neoplasm;Prognosis;prototype;Public Health;Refractory;Research;Resistance;Role;Series;small molecule inhibitor;SMARCA4 gene;SWI/SNF Family Complex;targeted treatment;Testing;Therapeutic;therapy outcome;TP53 gene;Tumor Suppressor Proteins;United States National Institutes of Health;Up-Regulation;Xenograft Model

PROJECT_TITLE: Synthetic lethality based combination approaches to ARID1A mutation in ovarian cancer


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Infectious Diseases;Prevention;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: VICTORIA

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY OF VICTORIA

ORG_STATE: BC

ORG_ZIPCODE: V8P 5C2

PI_NAMEs: CAMERON, CAROLINE E (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Adjuvant;Amino Acids;Animals;Area;Asia;Australia;Bacteria;Bacterial Proteins;Biological Assay;Blood Circulation;brain endothelial cell;Canada;candidate selection;Categories;CCL2 gene;Cell Culture Techniques;Cell Death;Cell Line;Cells;China;Cities;comparative;Congenital Syphilis;cytokine;Data;design;Development;differential expression;Disease;Disease Outbreaks;disorder control;disorder prevention;Early Diagnosis;Endothelial Cells;Endothelium;Epithelium;Europe;experimental study;Exposure to;Extracellular Matrix;Funding;IL8 gene;Immune Evasion;Immune response;in vivo;Infection;Infection prevention;Instruction;Interleukin-6;Investigation;Knock-out;Knowledge;Label;Macrophage;Maintenance;Measures;Mediating;Membrane Proteins;North America;novel;novel strategies;Organ;Organism;Oryctolagus cuniculus;pathogen;Pathogenesis;Pathogenicity;Penicillins;Placenta;Post-Translational Protein Processing;Predisposition;Prevalence;prevent;Prevention strategy;Principal Investigator;Process;programs;Proteins;Proteome;Proteomics;Public Health;Research;Research Project Grants;response;Role;Signal Pathway;Signal Transduction;Stable Isotope Labeling;Syphilis;syphilis vaccine;tandem mass spectrometry;Techniques;Time;Tissues;Transcript;transcriptome sequencing;transcriptomics;Treponema pallidum;Treponema pallidum adhesin;United States;vaccine candidate;vaccine development;Vascular Endothelial Growth Factors

PROJECT_TITLE: Extracellular Matrix Adhesins of Treponema pallidum


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Genetics;Human Genome;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: BERKELEY

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: NARRATIVE Central nervous system (CNS)-resident astrocytes and microglia interact to regulate pro-inflammatory programs that drive neurodegenerative diseases, but the pathways and molecules involved are largely unknown. Understanding the language of inflammation is a central question in the field of Neuroimmunology and may guide new therapeutic approaches for multiple sclerosis and other neurologic diseases. This proposal applies two novel high-throughput methods to study microglia-astrocyte interactions during CNS inflammation.

PI_NAMEs: CLARK, IAIN  (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Adopted;Alzheimer's Disease;Anti-Inflammatory Agents;Astrocytes;Autoantigens;Autoimmune Diseases;B-Lymphocytes;Bar Codes;Cell Communication;Cell surface;cell type;Cells;Central Nervous System;Central Nervous System Diseases;Central Nervous System Infections;Clustered Regularly Interspaced Short Palindromic Repeats;CNS autoimmune disease;Communication;cost;CRISPR library;CRISPR screen;CRISPR/Cas technology;Custom;Demyelinations;Dendritic Cells;Detection;disability;Disease;Dissection;Encapsulated;Environmental Risk Factor;Equilibrium;Equipment;Experimental Autoimmune Encephalomyelitis;Genes;Genetic;Genetic Screening;Genetic Transcription;genome wide screen;genome-wide;Genomics;glial activation;Health;high throughput technology;Homeostasis;Image;Immune;immune cell infiltrate;in situ sequencing;in vivo;Incubated;indexing;Individual;Infection;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Injury;invention;Language;Mediating;Methodology;Methods;Microglia;Molecular;monocyte;mouse model;Multiple Sclerosis;Mutation;Nerve Degeneration;Nervous System Disorder;Nervous System Physiology;Neurodegenerative Disorders;neuroimmunology;Neurons;novel;novel strategies;novel therapeutic intervention;Oils;Oligodendroglia;p65;Pathogenicity;Pathway interactions;Peripheral;Phase;Physiological;Process;programs;rabies viral tracing;rabies virus barcoding;recruit;Regulation;Reporter;Resolution;response;RNA Sequences;single cell sequencing;single-cell RNA sequencing;Sorting;spatial relationship;Structure;T-Lymphocyte;Technology;Therapeutic;tissue repair;Tissues;tool;transcriptional reprogramming;transcriptome;Water

PROJECT_TITLE: Decoding the language of inflammation between central nervous system resident immune cells


ADMINISTERING_IC: GM

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Networking and Information Technology R&D (NITRD)

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Project Narrative Carbohydrate-binding proteins (human, bacterial, or viral lectins and adhesins) and carbohydrate-processing enzymes (glycosyltransferases and glycosidases) are important targets for therapeutic intervention; however the creation of drug-like molecules that can competitively inhibit carbohydrate-binding sites is uniquely challenging. Computational approaches that are specifically designed to screen analogs of carbohydrates could be invaluable aids in both increasing the objectivity of the synthetic choices and in prioritizing the synthetic effort required for glycomimetic development. The creation and validation of such a tool is the focus of this proposal.

PI_NAMEs: WOODS, ROBERT J (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Address;Adhesions;Affinity;Agreement;analog;Anti-viral resistance;Antibiotics;Bacteria;Bacterial Adhesins;Binding;Binding Sites;Biological;carbohydrate analog;carbohydrate binding protein;carbohydrate receptor;carbohydrate structure;Carbohydrates;Cations;Cell Membrane Permeability;Cell surface;Cells;chemical property;Chemical Structure;Chemicals;Complex;Computer Models;computerized tools;Data;design;Development;Diarrhea;Disease;DNA Sequence Alteration;Docking;Down-Regulation;Drug Targeting;drug-like compound;Endocytosis;Enzymes;Evaluation;experience;experimental group;Familiarity;Food Poisoning;glycomimetics;Glycoside Hydrolases;glycosyltransferase;Hemagglutinin;Human;Hydrogen Bonding;Hydrophobicity;hydroxyl group;improved;In Situ;Infection;influenzavirus;Informatics;inhibitor;Intention;Intestines;lead optimization;Lectin;Libraries;Ligands;Mainstreaming;Mediating;Membrane Fusion;Methods;Modeling;Modification;Molecular Conformation;Mucous Membrane;Multiple Bacterial Drug Resistance;nanomolar;Nomenclature;novel therapeutics;Oligosaccharides;pathogen;Pathogenicity;Pharmaceutical Chemistry;Pharmaceutical Preparations;Polysaccharides;Positioning Attribute;predictive tools;Property;protein complex;Protein-Carbohydrate Interaction;Proteins;Reporting;Role;Salmonella;scaffold;Scheme;Scientist;screening;Seminal;Sialic Acids;simulation;Site;small molecule inhibitor;Specificity;structural biology;Structure;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Agents;Therapeutic Intervention;tool;Up-Regulation;Validation;van der Waals force;Variant;Viral;virtual screening;War;Water;web based interface

PROJECT_TITLE: Computational tools to aid the design of glycomimetic agents

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BEDFORD

ORG_NAME: EDITH NOURSE  ROGERS MEMORIAL VETERANS HOSPITAL

ORG_STATE: MA

PHR: Student Veterans with mental health disorders can experience significant difficulties in achieving their educational goals, including longer time to graduate and increased difficulties in academic task completion. This project will develop and evaluate a mobile app intervention, VetEd, with great potential to improve academic functioning by targeting the specific obstacles that Veterans with mental health disorders encounter during their pursuit of higher education. These goals are consistent with the Veterans Health Administration’s strategic plan to provide personalized, modern care options to enhance quality of life, independence, and financial stability by supporting Veteran educational attainment.

PI_NAMEs: REILLY, ERIN  (contact)

PROJECT_TERMS: Academic skills;Academic support;Address;Applications Grants;Area;assessment application;Attention;Award;Back;Behavioral;Caring;Catalogs;Clinic;Cognitive;college;community reintegration;Compensation;Computer software;Coping Skills;cost effective;Data;Degree Completion;design;Development;Diagnosis;Education;education planning;education research;Educational accommodation;Educational Intervention;Effectiveness;Emotional;Employment Opportunities;Enrollment;Exercise;expectation;experience;Face;Faculty;Family;Feedback;Focus Groups;functional improvement;Future;Goals;Health;health management;higher education;Housing;improved;innovation;Intervention;Investments;Leadership;Learning;Life;Literature;Manuals;meetings;Mental Depression;Mental disorders;Mental Health;mental health counseling;Military Personnel;mobile application;mobile computing;Modernization;novel;Outcome;Pain;Patient Self-Report;peer;Performance;Persons;Pilot Projects;Population;post 9/11;Post-Traumatic Stress Disorders;preference;Process;psychiatric symptom;Quality of life;randomized, clinical trials;Research;Resources;Risk Behaviors;Role;satisfaction;Self Efficacy;Self Management;Services;skills;Strategic Planning;stress management;student retention;Students;substance use;success;Suicide;Symptoms;Technology;Testing;Time;Transportation;usability;User-Computer Interface;validation studies;Veterans;Veterans Health Administration;Vocation;web app;Work

PROJECT_TITLE: Designing a Mobile App to Support Academic Success for Student Veterans

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Lung

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE In this proposal we will investigate the role of the transcriptional factor Blimp1 in controlling immune responses in the lungs. The results from these studies can contribute for the development of new therapies to treat chronic inflammatory conditions such as asthma.

PI_NAMEs: MARTINS, GISLAINE A (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Achievement;Acute;Adoptive Cell Transfers;airway inflammation;allergic airway inflammation;Alveolar Macrophages;Asthma;ATAC-seq;Award;B lymphocyte-induced maturation protein 1;Bacteria;Bacterial Infections;Bacterial Model;Binding;CD4 Positive T Lymphocytes;Cells;chromatin immunoprecipitation;Chronic;comparative;Complex;constitutive expression;cytokine;Development;Ensure;Environment;Equilibrium;Experimental Models;Exposure to;female reproductive tract;Flow Cytometry;FOXP3 gene;Funding;Gene Expression;Gene Expression Regulation;Genetic;Genetic Transcription;Goals;Hematopoietic;histone modification;Homeostasis;Human;IL17 gene;IL9 gene;Immune;Immune response;Immune Tolerance;Impairment;Infection;Inflammation;Inflammatory;Inflammatory Response;Influenza;Inhalation;Interleukin-10;Intestinal Mucosa;Intestines;Invaded;Knock-in;Location;Lung;Lung immune response;Lymphoid Cell;Macrophage;Maintenance;Mediating;Messenger RNA;MHC Class II Genes;Modeling;Molecular;Mucous Membrane;Mus;Myelogenous;Myeloid Cells;novel;novel therapeutic intervention;novel therapeutics;Ovalbumin;particle;pathogen;Pathogenesis;Pathway interactions;Play;Pneumonia;PRDM1 gene;prevent;Production;Property;pulmonary function;Pulmonary Inflammation;Pyroglyphidae;Regulation;Regulator Genes;Regulatory T-Lymphocyte;Reporter;Respiratory Mucosa;response;restraint;Role;Severity of illness;sialic acid binding Ig-like lectin;single-cell RNA sequencing;Stimulus;Streptococcus pneumoniae;Structure of parenchyma of lung;Surface;T-Lymphocyte;Testing;tissue repair;Tissues;transcription factor;transcriptome;transcriptome sequencing;Transgenic Mice;two photon microscopy;Viral;Visualization

PROJECT_TITLE: Role of Blimp1 (Prdm1) in lung immune responses and tolerance

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: PTSD and substance use disorders (SUD) are two of the most common and debilitating mental health conditions afflicting military Veterans. PTSD and SUD frequently co-occur and are associated with poorer treatment outcomes. Our team developed a trauma-focused intervention, Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure (COPE), which is identified by the VA as a gold standard of behavioral healthcare. However, a critical barrier to ensuring that Veterans with co-occurring PTSD/SUD receive evidence-based treatment is a lack of provider training. This proposed project, conducted in close partnership with the National Center for PTSD, will directly address this critical gap in provider training to improve the care of Veterans with comorbid PTSD/SUD, enhance treatment delivery using innovative in- session provider assistance tools, enhance knowledge of cost-benefit of technology-enhanced training, and inform best practices for VA dissemination of training programs.

PI_NAMEs: BACK, SUDIE E (contact)

PROJECT_TERMS: Address;Adoption;alcohol use disorder;Alcohols;Ambulatory Care Facilities;Back;Behavior;behavioral health;Caring;Clinical;Clinical Practice Guideline;Code;Cognitive Therapy;Collaborations;Communities;comorbidity;comparative cost effectiveness;Competence;cost;Cost Analysis;Cost Effectiveness Analysis;Cost-Benefit Analysis;Costs and Benefits;Data;Department of Defense;Development;Disaster Planning;Drug usage;Drug Use Disorder;E-learning;Educational workshop;Emotional;Enhancement Technology;Ensure;evidence base;Evidence based practice;Evidence based treatment;experience;Family;Funding;Goals;Guidelines;Guilt;Health;Health Personnel;Health Services Accessibility;Health Services Research;health training;Healthcare;Healthcare Systems;Hospitals;implementation facilitation;implementation science;improved;Individual;innovation;interest;Internet;Intervention;Knowledge;Knowledge acquisition;Lead;Leadership;Letters;Manuals;Measures;member;Mental Depression;Mental disorders;Mental Health;Mental Health Services;mental set;Methodology;Methods;Military Personnel;military veteran;novel;online resource;Online Systems;operation;pandemic disease;patient oriented;Patients;Persons;Phase;Play;Policies;post-pandemic;post-traumatic stress;Post-Traumatic Stress Disorders;Preparation;primary outcome;Protocols documentation;Provider;provider behavior;Randomized;Randomized, Controlled Trials;Recommendation;relapse prevention;Research;research and development;Research Priority;Role;Rural;rural health clinic;Sampling;satisfaction;service member;Sleeplessness;Specialist;Standardization;substance use;Substance Use Disorder;success;System;telehealth;Testing;theories;Time;timeline;tool;Training;Training Programs;Trauma;Travel;Treatment outcome;United States Department of Veterans Affairs;uptake;Veterans;Veterans Health Administration;virtual healthcare;whole health

PROJECT_TITLE: Web-Based Provider Training for Concurrent Treatment of PTSD and Substance Use Disorders using Prolonged Exposure (COPEWeb)

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

PHR: PROJECT NARRATIVE SMAC mimetics can boost antigen presentation in some cancer cells and enhance their response to immunotherapy, but it is unclear which subset of cancer patients can benefit from SMAC mimetic treatment in the clinic. This proposal will address the context dependencies of SMAC mimetics’ effects on cancer cells and identify the optimal combination with immunotherapy. The results from this study can enable effective use of SMAC mimetics for cancer treatment in the clinic.

PI_NAMEs: GU, SHENGQING  (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: anti-PD-1;Antigen Presentation;Antigen-Presenting Cells;Antigens;Area;cancer cell;cancer immunotherapy;Cancer Patient;cancer therapy;cancer type;career;career development;CD8-Positive T-Lymphocytes;Cell Line;Cell surface;cell type;Cells;Cellular biology;Clinic;Clinical;Clinical Research;Clinical Trials Design;Coculture Techniques;Collaborations;Combination immunotherapy;Combined Modality Therapy;Computational Biology;CRISPR screen;cytokine;cytotoxicity;Data;data mining;Defect;Dependence;Development Plans;Disease remission;Doctor of Philosophy;Down-Regulation;efficacy evaluation;Environment;epigenetic marker;Epigenetic Process;feature selection;Fellowship;Foundations;Gene Expression Regulation;Genetic;Genetic Transcription;genome-wide;Goals;Immune;immune checkpoint blockade;immune function;Immune response;immunoregulation;Immunotherapy;improved;In Vitro;in vivo;inhibitor-of-apoptosis protein;Knowledge;Leadership;Machine Learning;Major Histocompatibility Complex;Malignant Neoplasms;mathematical model;Mediating;Melanoma;Melanoma Cell;mimetics;Modeling;multiple omics;Neoplasm Transplantation;Outcome;Pathway interactions;Patients;personalized strategies;Phase I/II Clinical Trial;Phenotype;Play;Production;Regulation;Research;Resistance;Resources;response;response biomarker;Role;Sampling;Schedule;single cell technology;skills;small molecule;T-Lymphocyte;Testing;Therapeutic;Training Activity;transcriptome;Transition Career Development Award (K22);Translational Research;transplant model;Trust;tumor;Tumor Antigens;tumor immunology;tumor microenvironment;tumor progression;Up-Regulation;Validation;Work

PROJECT_TITLE: Enhancing the efficacy of immunotherapy by optimal use of SMAC mimetics

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-R (J1)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative RNA-binding proteins are emerging as principal modulators of every hallmark of cancer progression, however there is still little known about their cancer associated molecular functions and targets. ANGEL2, an RNA- binding protein, whose expression was found to be downregulated in multiple cancers, was found to modulate the expression of the tumor suppressor TP53. Consequently, this project aims to dissect the role of ANGEL2 in TP53-mediated tumor suppression, and to develop ANGEL2-derived peptides to enhance wild-type TP53 expression as a novel therapeutic approach.

PI_NAMEs: LUCCHESI, CHRISTOPHER AUGUST (contact)

PROGRAM_OFFICER_NAME: VAHEDI, SHAHROOZ

PROJECT_TERMS: 3-Dimensional;Adopted;Amino Acids;Award;Binding;biophysical techniques;biophysical tools;cancer cell;cancer therapy;cancer type;career;career development;Cell Line;Cells;Chemoresistance;chemotherapeutic agent;clinically significant;Collaborations;Coupled;Data;design;Development;Disease;Disease-Free Survival;Drug Design;Environment;Eukaryotic Initiation Factors;Foundations;Gene Expression;Genetic Transcription;Genome;Goals;Growth;Human;improved;Knock-out;Knowledge;Laboratory Research;Leadership;Malignant - descriptor;Malignant Neoplasms;Mediating;Medicine;member;Mentors;Messenger RNA;Modeling;Molecular;Morphology;mRNA Stability;mRNA Translation;Mutation;next generation;non-genetic;novel;novel therapeutic intervention;novel therapeutics;Oncogenes;Organoids;Pathway interactions;Patients;peptide drug;Peptides;Phenotype;Play;prevent;Productivity;Protein Binding Domain;protein expression;Protein Family;Repression;Research;Research Personnel;Resources;RNA Binding;RNA-Binding Proteins;Role;Scientist;sensor;Signal Pathway;skills;spheroids;Stress;synthetic peptide;Testing;Therapeutic;TP53 gene;Training;Transcript;transcription factor;Transition Career Development Award (K22);Translational Repression;Translational Research;Translations;tumor;tumor growth;tumor progression;Tumor Suppression;Tumor Suppressor Genes;Tumor Suppressor Proteins;tumorigenesis;virtual;Xenograft procedure

PROJECT_TITLE: The role of ANGEL2 in TP53-dependent tumor suppression

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Cachexia;Cancer;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: Aurora

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Musculoskeletal complications associated with the occurrence of cachexia afflict up to 80% of patients diagnosed with cancer, and equally impact the quality of life in cancer survivors. By using in vitro and in vivo experimental models, we will define new pathological mechanisms of muscle wasting resulting from elevated tumor-derived RANKL and associated with bone resorption. This study will shed light on novel mechanisms of cachexia and identify RANKL as a therapeutic target for the treatment of musculoskeletal complications associated with non- metastatic RANKL-expressing cancers.

PI_NAMEs: BONETTO, ANDREA  (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Advanced Malignant Neoplasm;Affect;Animals;Antibodies;Atrophic;Binding;Body Weight decreased;bone;bone loss;bone mass;bone preservation;Bone Resorption;C26 tumor;Cachexia;Cancer Cachexia;cancer cell;Cancer Survivor;Cells;Cessation of life;chemotherapy;Chronic Disease;circulating biomarkers;Coculture Techniques;Colorectal Neoplasms;comorbidity;Complication;Cyclophosphamide;Defect;Diagnosis;Exhibits;Experimental Models;Exposure to;Fiber;Goals;Growth;Implant;improved;In Situ Nick-End Labeling;In Vitro;in vivo;in vivo evaluation;Interleukin-6;Ligands;Malignant neoplasm of ovary;Malignant Neoplasms;Membrane;Metastatic Neoplasm to the Bone;mouse model;Mus;Muscle;Muscle Fibers;muscle form;muscle strength;Muscular Atrophy;Musculoskeletal;Musculoskeletal Diseases;neutralizing antibody;new therapeutic target;NF-kappa B;Nonmetastatic;novel;Osteoclasts;Osteocytes;Osteogenesis;Osteolysis;Osteoporotic;ovarian neoplasm;overexpression;Pathologic;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Play;preservation;Publishing;Quality of life;receptor;Receptor Activation;Recombinants;Research;Rodent;Role;Secondary to;skeletal;Skeletal Muscle;Symptoms;therapeutic target;tumor;Tumor-Derived;Woman;Zoledronate

PROJECT_TITLE: Targeting RANKL for the treatment of muscle and bone defects in cachexia

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: SEATTLE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Generating physiologically thick, functional, and organized cardiac tissue patches for the use in regenerative medicine applications remains a major engineering challenge. Heart tissue is highly organized, and vascularization and tissue alignment are important architectural features. We propose a novel approach using open microfluidics to generate thick cardiac tissue that incorporates vascularization and alignment for the ultimate implantation into patients to replace damaged tissue.

PI_NAMEs: HAACK, AMANDA JEAN (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: 3-Dimensional;Address;angiogenesis;Animal Model;Animals;Architecture;Area;bioprinting;Blood Vessels;Calcium;Cardiac;cardiac implant;Cardiac Myocytes;cardiac tissue engineering;Cause of Death;Cell Culture Techniques;Cells;Cessation of life;Collagen;Complex;confocal imaging;Contracts;Coupled;crosslink;Culture Techniques;Data;density;Development;Diameter;EFRAC;Encapsulated;Endothelial Cells;Endothelium;Engineering;Extracellular Matrix;fabrication;Fiber;Fibrin;Future;Gel;Generations;Goals;healthy lifestyle;Heart;heart damage;Heart Diseases;Heart failure;heart function;Human;Hydrogels;Implant;implantation;improved;In Situ;In Vitro;in vivo;Investigation;Isometric Exercise;Legal patent;Length;Liquid substance;Measurement;Measures;Mechanics;Methods;Microfluidic Microchips;microfluidic technology;Microfluidics;mimetics;Morphology;Myocardial Infarction;Necrosis;Needles;novel;novel strategies;Patients;Pattern;Perfusion;Pharmaceutical Preparations;Physiological;Polyethylene Glycols;Regenerative Medicine;Sarcomeres;Shapes;shear stress;Stains;stem cells;Stimulus;Structure;success;Surface;Surface Tension;Techniques;Thick;Thinness;Tissue Engineering;Tissues;Translating;Trees;Vascularization;virtual;Work

PROJECT_TITLE: Generating multilayered engineered heart tissue patches to mimic physiological thickness and function using open microfluidics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Urologic Diseases;Women's Health Research

PHR: PROJECT NARRATIVE Urge urinary incontinence is a common problem in older people which vastly reduces quality of life, yet the cause and mechanism of disease are not well understood. This study will characterize brain control of the bladder in young and old continent individuals and age-matched wet counterparts. This will expand our current knowledge of how the brain controls the bladder, better characterize the `ideal' mechanism and suggest ways in which we can better target treatment.

PI_NAMEs: CLARKSON, BECKY D (contact)

PROGRAM_OFFICER_NAME: SAZONOVA, IRINA Y

PROJECT_TERMS: Address;Age;age group;age related;age related changes;aged;Aging;aging process;analytical method;Behavior Therapy;Behavioral;Benign;Biofeedback;Bladder;Bladder Control;Bladder Dysfunction;Brain;brain abnormalities;brain control;brain dysfunction;Brain imaging;Cerebrum;Clinical;cohort;Compensation;Complement;cost;Cross-Sectional Studies;Data;Development;Disease;Elderly;Failure;Functional Imaging;Goals;High Prevalence;human old age (65+);improved;Incidence;Incontinence;Individual;innovation;Investigation;Knowledge;life span;Machine Learning;Magnetic Resonance Imaging;Medial;Mediating;Micturition Reflex;Midbrain structure;Modeling;neuroimaging;Neurosciences;novel;novel therapeutics;older adult;Older Population;Phenotype;predicting response;Prefrontal Cortex;Premenopause;Quality of life;Reaction;recruit;Refractory;research clinical testing;Research Personnel;Resistance;response;Role;Scientist;side effect;Spasm;structural imaging;Structure;targeted treatment;Therapeutic;treatment response;Urinary Incontinence;Woman;Women's study;young adult

PROJECT_TITLE: Investigation of brain mechanisms involved in the Urinary Continence mechanism associated with aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-B(90)]


NIH_SPENDING_CATS: Biotechnology;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Vaccines for various infectious diseases have been one of the most successful global health initiatives, however, full efficacy is only provided to those with an intact immune system. By investigating the immunologic and metabolic landscape following successful vaccination in immunocompromised individuals, we aim to uncover pathways that can be targeted to improve vaccine responses in at risk populations. This work will provide basic mechanistic insights into successful vaccination and identify vaccine adjuvants that modulate metabolic reprogramming to enhance vaccine responses in immunocompromised individuals.

PI_NAMEs: THOMPSON, ELIZABETH ANNE (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;Advisory Committees;Antibody Formation;Antibody Response;Antigen Presentation;Automobile Driving;B Cell Proliferation;B-Cell Activation;B-Cell Development;B-Lymphocytes;Biometry;career development;Career Transition Award;Cell Communication;Cell Count;Cell Physiology;Cells;Clinical;cohort;Communicable Diseases;COVID-19 pandemic;COVID-19 vaccination;Data;defined contribution;Development;Doctor of Philosophy;Elderly;expectation;experience;Faculty;fatty acid oxidation;Fatty Acids;Frequencies;Future;global health;Goals;Grant;Hematologic Neoplasms;HIV;Immune response;Immune system;Immunocompromised Host;immunogenic;Immunologics;Immunology;Immunology procedure;immunosuppressed;Immunosuppression;Immunosuppressive Agents;improved;In Vitro;Individual;insight;Institution;ITGAX gene;Knowledge;Laboratories;Leadership;Learning;lipid metabolism;Lipids;long chain fatty acid;medical schools;Metabolic;Metabolic Pathway;Methods;Mitochondria;mitochondrial metabolism;Modeling;multidimensional data;novel;novel vaccines;organ transplant recipient;oxidation;oxidized lipid;Pathway interactions;patient population;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Phenotype;Population;Populations at Risk;Postdoctoral Fellow;Principal Investigator;programs;Proliferating;Qualifying;Regimen;Research;research and development;Research Personnel;response;Reverse engineering;Role;Running;Sampling;Scientist;skills;Solid;System;T memory cell;T-Cell Activation;T-Lymphocyte;Techniques;Technology;Testing;Training;Universities;Up-Regulation;Vaccination;Vaccine Adjuvant;vaccine formulation;vaccine response;vaccine strategy;vaccine-induced antibodies;Vaccines;vaccinology;Work;Writing

PROJECT_TITLE: Targeting lipid-oxidizing B cells to enhance vaccine responses during immunosuppression

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Aging;Biotechnology;Cardiovascular;Genetics;Heart Disease;Hematology;Human Genome;Lung;Pulmonary Fibrosis;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: Project Narrative Many elderly men have a condition where a portion of their blood cells lose the Y chromosome, which may accelerate aging and age-related diseases, contributing in part to the five-year average reduced life expectancy in men compared to women. In this proposal, I will investigate how loss of Y chromosome in blood cells promotes accelerated aging phenotypes through dysregulated immune cell functions leading to increased accumulation of senescent cells and mesenchymal cell transitions. These findings will identify potential therapies to target mechanisms of aging that could increase lifespan of men with loss of the Y chromosome.

PI_NAMEs: CHAVKIN, NICHOLAS W (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Ablation;Affect;Age;age acceleration;age related;Age related pathologies;age-related disease;aged;Aging;aging mechanism;aging related;Aneuploidy;aorta constriction;Area;Binding;Biological Aging;Blood Cells;Cardiomyopathies;Cardiovascular Diseases;Cell Aging;Cell Culture Techniques;Cell Physiology;Cells;Cellular biology;Chromatin;chromosome Y loss;coronary fibrosis;CRISPR/Cas technology;Data;Death Rate;Dementia;Elderly man;Endothelial Cells;Endothelium;Environment;epidemiologic data;Epigenetic Process;extend lifespan;Fibroblasts;Fibrosis;Functional disorder;Gene Expression;General Population;Genes;Genetic Transcription;healthspan;Heart failure;Heart Injuries;Hematopoiesis;Hematopoietic;Hematopoietic Stem Cell subsets;Hematopoietic Stem Cell Transplantation;Hematopoietic System;histone demethylase;histone modification;Human;Immune;Impaired cognition;Incidence;Inflammatory;insight;interest;kidney fibrosis;Leukocytes;Life Expectancy;life span;Ligands;Link;Macrophage;Malignant Neoplasms;Mediating;men;Mesenchymal;Methods;Modification;mortality;mosaic loss;Mosaicism;mouse model;Mus;mutant;Mutate;Mutation;Myocardial tissue;novel;old mice;Pathology;Patients;Persons;Phenotype;Population;Prevalence;pro-aging;Process;programs;Pulmonary Fibrosis;recruit;Research;response;Role;senescent cell;single cell analysis;single cell ATAC-seq;single-cell RNA sequencing;skills;Somatic Mutation;therapeutic target;tissue culture;Tissues;Training;transcription factor;transcriptome sequencing;Transgenic Mice;women versus men;Y Chromosome

PROJECT_TITLE: The Role of Hematopoietic Loss of Y Chromosome on Aging Phenotypes

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Clinical Research;Immunotherapy;Lung;Prevention;Radiation Oncology

ORG_CITY: COLUMBIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative In this proposal, we will investigate autoimmune mechanisms of cardiac and lung toxicities from thoracic irradiation in the presence of PD-1 blockade. Outcomes of the proposed studies will help to identify novel biomarkers for early diagnosis of serious and fatal adverse events and novel therapeutic targets for managing the toxicities and improving therapeutic ratio.

PI_NAMEs: LU, BO  (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: adaptive immune response;adaptive immunity;Address;Adoption;Adverse event;anti-CD20;anti-PD-1;anti-PD1 therapy;Autoantibodies;Autoimmune;Autoimmune Diseases;Autoimmune Process;autoimmune toxicity;Autoimmunity;B-Lymphocytes;bench to bedside;Biological;Blood;Blood specimen;Cancer Patient;Cardiac;Cardiopulmonary;CD19 gene;CD4 Positive T Lymphocytes;Cells;Chest;Clinical;Clinical Research;Collaborations;Combined Modality Therapy;cytokine;Diagnosis;Diagnostic tests;Discipline;Early Diagnosis;Excess Mortality;Exposure to;Foundations;Goals;Heart;Humoral Immunities;humoral immunity deficiency;IL17 gene;Immune;immune checkpoint;Immunologist;Immunotherapy;improved;improved outcome;Inflammatory;inhibitor;Injury;Innate Immune Response;Institution;Intervention;Investigation;irradiation;Knockout Mice;Laboratories;Lead;Life;Link;LoxP-flanked allele;Lung;Malignant neoplasm of lung;Measures;Mediating;Modeling;Monitor;mouse model;Mus;Natural Immunity;neutrophil;new therapeutic target;novel;novel diagnostics;novel marker;Outcome;Patients;PD-1 blockade;pharmacologic;pre-clinical;Pre-Clinical Model;predictive marker;prevent;Production;programmed cell death protein 1;prospective;Quality of life;Radiation Oncologist;Radiation therapy;response;Role;Sampling;Serum;Structure of parenchyma of lung;T-Lymphocyte;Testing;Therapeutic;therapeutic target;Toxic effect;Toxicity Attenuation;translational study;Universities;Validation;Wild Type Mouse;Work

PROJECT_TITLE: Autoimmunity in Cardiopulmonary Toxicities from Radiotherapy andImmunotherapy

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Prevention;Primary Health Care;Tobacco;Tobacco Smoke and Health

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Quitlines are effective, evidence-based smoking cessation interventions; yet, primary care referral rates to Quitlines remain low. A critical knowledge gap is how best to implement Quitline referral systems into health care settings to ensure maximum reach and effectiveness of cessation services, particularly among socioeconomically disadvantaged patients who smoke. This pragmatic study uses a cluster-randomized controlled trial (n=30 Oregon community health centers; n~15,000 smokers) to 1) examine smoking cessation assistance reach and effectiveness of implementation of a Quitline eReferral system with enhanced academic detailing (intervention condition) compared with implementation without enhanced academic detailing (comparison condition), and 2) evaluate the cost-effectiveness of the Quitline eReferral system, both with and without enhanced academic detailing.

PI_NAMEs: BAILEY, STEFFANI R (contact)

PROGRAM_OFFICER_NAME: RODITIS, MARIA LEIA

PROJECT_TERMS: Academic Detailing;Address;Adult;Back;Caring;Centers for Disease Control and Prevention (U.S.);Clinic;Cluster randomized trial;Collaborations;Communities;cost;cost effective;cost effectiveness;cost-effectiveness evaluation;Counseling;Data;design;Disparity;Economically Deprived Population;Education and Outreach;Effectiveness;effectiveness evaluation;Electronic Health Record;electronic health record system;Enrollment;Ensure;evidence base;experience;Feedback;Goals;Health;health care settings;health information technology;Health Personnel;Healthcare;Household;Hybrids;implementation strategy;implementation/effectiveness;improved;Income;incremental cost-effectiveness;individual patient;Inequality;innovation;Intervention;Knowledge;Medicaid;Methods;Morbidity - disease rate;mortality;National Cancer Institute;Neighborhood Health Center;Oregon;Outcome Study;participant enrollment;patient oriented;Patient Self-Report;Patients;Performance;Persons;Pharmaceutical Preparations;Physicians;Population;pragmatic study;pragmatic trial;Primary Care;primary care setting;Printing;Procedures;Process;programs;Provider;Public Health;quitline;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research Priority;service utilization;Services;Smoke;Smoker;Smoking;smoking cessation;Smoking Cessation Intervention;smoking prevalence;socioeconomic disadvantage;Standardization;System;Telefacsimile;Tobacco;tobacco user;Training;treatment guidelines;Uninsured;United States;uptake;Vulnerable Populations

PROJECT_TITLE: CONNECT: COmpreheNsive traiNing and Engagement in Cessation Treatment

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Chronic Pain;Genetics;Human Genome;Microbiome;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Wound Healing and Care

ORG_CITY: NEW YORK

ORG_DEPT: DERMATOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative Peripheral neuropathy is a major health concern, demanding novel approaches for the restoration of injured nerves. Protection and restoration of peripheral neuron system upon barrier tissue injury happen in the context of the immune response to the microbiota. This proposal will study how the microbiota-specific immune response promotes peripheral nerve regeneration, with the goal to identify novel therapeutic approaches to promote somatosensory recovery and mitigate neuropathies and chronic pain.

PI_NAMEs: ENAMORADO ESCALONA, NERIS MICHEL  (contact)

PROJECT_TERMS: Ablation;activating transcription factor 3;Affect;afferent nerve;Afferent Neurons;Area;ATAC-seq;Award;axon regeneration;Basic Science;Bioinformatics;bioinformatics tool;Biological Availability;Blocking Antibodies;Breeding;career;career development;Cervical;Chemicals;chronic pain;Clinical Research;Collaborations;commensal microbes;Communication;comparison control;Complement;Confocal Microscopy;Core Facility;cytokine;Data;Diphtheria Toxin;disability;Doctor of Philosophy;Ear;Educational process of instructing;Educational workshop;Ensure;Environment;epigenomics;experimental study;Fiber;Formulation;gene regulatory network;Genes;Genetic Transcription;Goals;Health;Hyperalgesia;IL17 gene;Immune;Immune response;Immunity;Immunologics;Immunology;improved;injured;Injury;injury and repair;insight;Institution;Interleukins;International;Intramural Research Program;K-Series Research Career Programs;Knowledge;Laboratories;Longitudinal Studies;mechanical allodynia;Mechanics;Mediating;Mentors;microbiome;microbiota;Microscopy;Modeling;Molecular;mouse model;Mus;Natural regeneration;Nerve Fibers;nerve injury;Nerve Pain;Nerve Regeneration;nerve transection;Nervous System Trauma;Neuroimmune;neuroimmunology;neuron regeneration;Neuronal Injury;Neurons;Neuropathy;neurotrophic factor;novel strategies;novel therapeutic intervention;novel therapeutics;Oral;Pain;Pain Measurement;pain sensation;Peripheral;peripheral nerve regeneration;Peripheral Nervous System;Peripheral Nervous System Diseases;Persons;receptor;Recovery;Recovery of Function;Regulation;Research;Research Personnel;Resources;response;restoration;Role;sciatic nerve;Sensory;Signal Transduction;single-cell RNA sequencing;Site;skills;Skin;Skin injury;somatosensory;Spinal Ganglia;Staphylococcus aureus;symposium;System;T cell response;T-Lymphocyte;teacher;Testing;Therapeutic;therapeutic evaluation;Tissue Engineering;tissue injury;Tissues;Training;transcription factor;transcription regulatory network;transcriptomics;Translating;Translational Research;United States;United States National Institutes of Health;Up-Regulation;Work;wound healing

PROJECT_TITLE: Roles of immunity to the microbiota in peripheral nerve regeneration and pain sensation.


ORG_CITY: SAINT LOUIS

ORG_NAME: SAINT LOUIS UNIVERSITY

PHR: PROJECT NARRATIVE Because natural killer cells are important for controlling infections and cancer, clinicians are exploring them as a cellular therapy. Technologic developments have made tremendous progress in our understanding of factors that correlate with patient outcomes in these studies, but definitive human experiments using quick and economic clinical trials to evaluate specific hypotheses are not possible. However, understanding the interplay between adoptively transferred cells, the recipient immune system, and disease in an immune-competent/syngeneic environment will improve our ability to design clinical trials that have the highest chance for success.

PI_NAMEs: ELLIOTT, MELISSA BERRIEN (contact)

PROJECT_TERMS: Address;Adoptive Cell Transfers;Allogenic;Animals;anti-viral efficacy;Antigens;Antitumor Response;Autologous;Biological Assay;Biological Models;Budgets;Cancer Patient;cancer therapy;career;career development;Cell Differentiation process;Cell Therapy;Cells;Cellular biology;chemokine;chimeric antigen receptor;chimeric antigen receptor T cells;Clinic;Clinical;Clinical Immunology;Clinical Trials;Clinical Trials Design;cytokine;cytotoxic;design;Development;Development Plans;Disease;Economics;education resources;Effector Cell;efficacy evaluation;Emerging Technologies;Endowment;Enrollment;Environment;experimental study;Explosion;Faculty;Failure;fitness;flexibility;Future;Gene Modified;Genes;Goals;Hematologic Neoplasms;Homing;Human;IL18 gene;Immune;Immune response;Immune system;Immunocompetent;Immunocompromised Host;Immunologics;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vitro activity;in vivo;in vivo evaluation;Infection;Infection Control;Institution;interest;Interleukin-12;Interleukin-15;Intrinsic factor;K-Series Research Career Programs;Laboratory Research;Learning;Lymphocyte;Malignant Neoplasms;Memory;Mentorship;Metabolic;Molecular;mouse model;Mus;Natural Killer Cells;novel;novel strategies;novel therapeutic intervention;Outcome;Patient-Focused Outcomes;Patients;Phenotype;Positioning Attribute;Process;Production;programs;Property;prophylactic;Protocols documentation;receptor;receptor expression;Research;Research Project Grants;Resistance;Resources;response;Running;Safety;Sampling;Solid Neoplasm;Specificity;success;System;T-Lymphocyte;technology development;tenure track;Testing;Therapeutic Agents;Toxic effect;trafficking;Training;Translating;translational immunology;tumor;tumor microenvironment;Universities;Virus Diseases;Washington;Work;Xenograft procedure

PROJECT_TITLE: Elucidating Mechanisms of CAR ML NK cell biology to treat cancer and infection


ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Program Narrative We seek to discover the mechanisms of the dynamic contacts of neighboring cells as well as between cells and the extracellular matrix that hold animal cells together. These junctions additionally communicate signals and control the stress placed upon cells. Since the regulation and dysregulation of cell junctions are fundamental to many biological processes such as development and cancer, our proposed studies are therefore significant to our basic mechanistic understanding that could eventually result in a translational impact.

PI_NAMEs: IZARD, TINA  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Acceleration;Actin-Binding Protein;Actins;Adherens Junction;Adhesions;alpha catenin;Animals;Award;Binding;Biochemical;Biological Process;Cardiac;Cell Adhesion;Cell membrane;cell motility;Cell Proliferation;Cell-Cell Adhesion;Cell-Matrix Junction;Cells;Communication;Cytoskeleton;Development;Epithelium;Extracellular Matrix;Focal Adhesions;Foundations;Funding;Genes;Homeostasis;Intercellular Junctions;Knowledge;Laboratories;Link;Lipid Binding;Malignant Neoplasms;mechanotransduction;Mediator;Molecular;National Institute of General Medical Sciences;Play;prevent;Process;programs;Protein Isoforms;Regulation;Research;Research Personnel;Resolution;Role;Signal Transduction;Stress;structural biology;Structure;Talin;Techniques;Tissues;Transcript;translational impact;translational potential;transmission process;Vinculin

PROJECT_TITLE: Molecular Mechanisms of Cell Adhesion

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Genetics;Nutrition;Obesity

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Enhanced brown/beige fat biogenesis is associated with a substantial improvement in metabolic health; however, how this process is regulated remain insufficiently understood. Building upon our recent discovery of a novel ubiquitin E3-ligase complex that controls the protein stability of PRDM16, a dominant transcriptional regulator of brown/beige fat biogenesis, this proposal aims to understand the physiological role and biochemical mechanisms through which the E3-ligase complex controls whole-body energy metabolism. The work resulting from this application will establish a new roadmap to improve metabolic health through the post- translational control of PRDM16, while avoiding side effects that are associated with conventional brown/beige fat activators, such as cold and PPARγ agonists.

PI_NAMEs: KAJIMURA, SHINGO  (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Adipose tissue;Adrenergic Receptor;Agonist;Amyloid Proteins;Animal Model;Area;Binding Proteins;Biochemical;Biogenesis;Biological;blood glucose regulation;Branched-Chain Amino Acids;Bypass;Cardiovascular Diseases;Catabolism;Cells;Chronic;Code;Complex;Cues;Cullin 2 Protein;Cullin Proteins;Data;Dyslipidemias;Energy Metabolism;Extracellular Matrix;FAT gene;Fatty acid glycerol esters;fatty acid oxidation;Fibrosis;Genes;Genetic;Genetic Transcription;genetic variant;Glucose Intolerance;glucose tolerance;Half-Life;Health;Homeostasis;Hormonal;Human;Impairment;improved;Inflammation;innovation;Insulin Resistance;insulin sensitivity;Knockout Mice;Ligands;Link;lipid biosynthesis;Lipids;Lipolysis;Metabolic;Metabolic Diseases;metabolic phenotype;Mitochondria;Modeling;molecular phenotype;mouse model;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Obesity;Organ;oxidation;Pathway interactions;Physiological;Play;Post-Translational Regulation;PPAR gamma;prevent;Process;programs;Proteins;receptor;recruit;Regulation;Research;response;Role;side effect;Stimulus;Substrate Specificity;Testing;Thermogenesis;Thiazolidinediones;Transcription Coactivator;ubiquitin-protein ligase;Ubiquitination;uncoupling protein 1;Variant;Work

PROJECT_TITLE: Post-translational control of adipose tissue remodeling and metabolic health

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Genetics;Prevention

ORG_CITY: CINCINNATI

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE:  The Fernald Community Cohort (FCC) consists of the 9782 persons who participated in the Fernald Medical Monitoring Program (FMMP) from 1990-2008. The FMMP was an 18-year medical surveillance program for community residents living near the former US Department of Energy uranium processing site at Fernald (near Cincinnati), Ohio. Because of the exposure pathway modeling, extensive collection of blood and urine biospecimens collected throughout the 18-year period, the periodic comprehensive medical examinations, and questionnaire data designed to assess environmental exposures as well as general health information, this cohort can be used to study a wide range of exposures and their health outcomes.

PI_NAMEs: PINNEY, SUSAN MENGEL (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Address;Algorithms;biobank;Biological;Biological Markers;biological specimen archives;biomedical informatics;Blood;cell free DNA;Cell Separation;Centers for Disease Control and Prevention (U.S.);Cessation of life;Code;cohort;Collection;Common Data Element;Communication;Communities;Community Physician;Data;data dictionary;Data Element;Data Set;Databases;Department of Energy;Deposition;design;Diagnosis;Disease;disease diagnosis;disease phenotype;Disease susceptibility;DNA Methylation;Dose;dosimetry;drinking water;Eligibility Determination;Enrollment;Environmental Epidemiology;Environmental Exposure;Environmental Health;epigenomics;Equipment and supply inventories;exosome;experience;exposure pathway;Exposure to;Family Relationship;family structure;Feasibility Studies;follow-up;Funding;General Population;genetic pedigree;Genetic Predisposition to Disease;Genetic Variation;Health;Health Status;improved;Incidence;indexing;Individual;informatics tool;Ionizing radiation;Journals;Link;liquid biopsy;Malignant Neoplasms;Manuscripts;Measures;Medical;medical examination;Medical Records;Medical Surveillance;member;Metadata;MicroRNAs;Modeling;Molecular Epidemiology;molecular marker;Monitor;Names;National Institute of Environmental Health Sciences;new technology;next generation;Ohio;Ontology;Outcome;Peer Review;Periodicals;Persons;Pharmaceutical Preparations;Phenotype;Plants;Plasma;Plasma Cells;Population;Procedures;programs;Proteomics;Publishing;quality assurance;Questionnaires;Radiation exposure;Radon;reconstruction;Recording of previous events;Registries;repository;Research;Research Activity;Research Personnel;Research Project Grants;research study;Resource Sharing;Resources;Risk Factors;Sampling;Serum;Site;Source;Surveillance Program;Testing;Tissues;tool;United States National Institutes of Health;Universities;Update;Uranium;Urine;Water;Water Pollutants;web portal;web site

PROJECT_TITLE: Fernald Community Cohort: Research Resource for Environmental Epidemiology


ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE T cells express enormously diverse antigen receptors, allowing them to specifically recognize and combat a plethora of pathogens and cancers throughout life; however, when T cells first develop in the thymus, many acquire the dangerous ability to recognize our own cells. To circumvent autoimmunity, developing T cells enter the central region of the thymus, the medulla, where they encounter an array of self-proteins that cause autoreactive T cells to either die or to alter their activity to protect against autoimmunity. In this proposal, we will elucidate mechanisms by which the chemokine receptors CCR4 and CCR7 instruct developing T cells to enter the medulla, and promote encounters with other cells therein to promote self-tolerance.

PI_NAMEs: EHRLICH, LAUREN ILYSE RICHIE (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Agonist;Antigen Receptors;Antigen-Presenting Cells;Antigens;Autoantigens;Autoimmunity;Automobile Driving;autoreactive T cell;autoreactivity;Biological Assay;Blood;Bone Marrow;CC chemokine receptor 4;Cell Survival;Cells;central tolerance;chemokine receptor;Chimera organism;combat;Dangerousness;Data;Dendritic Cells;differential expression;Ensure;experimental study;Funding;Genetic;Impairment;Individual;innovation;Life;Ligands;Malignant Neoplasms;Mature Thymocyte;Mediating;migration;Modeling;Molecular;mosaic;mouse model;novel;pathogen;Peripheral;Play;prevent;Process;Proteins;Proteome;receptor expression;Regulatory T-Lymphocyte;Reporting;Role;Scanning;Self Tolerance;Structure of thymic medulla;T cell receptor repertoire sequencing;T-cell receptor repertoire;T-Lymphocyte;Testing;Thymic epithelial cell;thymocyte;Thymocyte Selection;Thymus Gland;Tissues;two photon microscopy

PROJECT_TITLE: Distinct contributions of CCR4 versus CCR7 to thymocyte localization and central tolerance

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ORG_CITY: LA JOLLA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Schmidt – Project Narrative Reactive radical species are responsible for essential biochemical processes and are implicated in various disease pathways making the Investigation of fundamental radical reactivity-selectivity profiles essential to understanding the chemical underpinnings of these vital systems. This work proposes to investigate the reactivity of carbon, oxygen, and sulfur-centered radicals with reduced phosphorous-based reagents. Additionally, this work will lead to the development of new synthetic methods with potential applications in the preparation of pharmaceuticals and new molecular tools in chemical biology.

PI_NAMEs: SCHMIDT, VALERIE ANNE (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Radical-Mediated Atom-Transfer Strategies for Chemical Synthesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Human Genome;Liver Disease;Organ Transplantation;Transplantation

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: NARRATIVE Cell-free DNA (cfDNA) is released from dying cells into the circulation and can be detected through non-invasive liquid biopsy analysis. Decoding the cellular origins of cfDNA reveals changes in tissue homeostasis and altered cellular death rates due to tissue damage; thus, this approach is emerging as a powerful diagnostic resource for monitoring cancer dynamics, graft dysfunction in transplantation, prenatal testing and many other areas of medicine. In this proposal, I plan to track cellular damage after liver transplants and use this information to improve diagnosis and management of graft dysfunction that involves damage to multiple cell types, including donor-derived tissue-resident immune cells and other cell-types composing the liver.

PI_NAMEs: BAREFOOT, MEGAN EVELYN (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Acute;Adverse event;Allografting;Apoptosis;Area;Biliary;Biological;Biopsy;Blood specimen;Blood Vessels;Cell Death;cell free DNA;cell injury;cell type;Cells;Cessation of life;Characteristics;chemotherapy;Chimerism;cholangiocyte;Circulation;Clinical;clinical decision-making;clinically significant;COVID-19 pandemic;Data;Death Rate;Decision Making;Detection;Development;Diagnosis;Diagnostic;Disease;Disseminated Malignant Neoplasm;DNA;DNA Methylation;Endothelium;Engraftment;Enzymes;Exhibits;Frequencies;Functional disorder;Genetic;Genome;genome sequencing;Genomics;Genotype;Goals;graft dysfunction;Hepatic;Hepatocyte;Heterogeneity;Homeostasis;Human;Human body;Immune;Immunosuppression;Immunosuppressive Agents;improved;Infection;Injury;innovation;insight;Intervention;Link;liquid biopsy;Liver;liver biopsy;Liver Circulation;Liver Function Tests;liver injury;liver transplantation;longitudinal analysis;Longitudinal Studies;Malignant neoplasm of liver;Malignant Neoplasms;Measures;Medicine;Methylation;methylation biomarker;methylation pattern;methylome;minimally invasive;Molecular;Molecular Analysis;Monitor;Morphology;Necrosis;novel;Organ;Organ Donor;Organ Transplantation;Outcome;Pathologic;Physiologic Monitoring;Physiological;Population;prenatal testing;Process;Proteins;Reaction;Recurrence;Reperfusion Injury;Research;residence;Resources;Role;Sampling;Series;Serum;Solid;Surgical complication;System;targeted treatment;Therapeutic;Therapeutic Intervention;Time;Tissue Donors;Tissues;tool;transcriptome sequencing;Transplant Recipients;Transplantation;Treatment Efficacy;whole genome

PROJECT_TITLE: Decoding the Tissue of Origin of Cellular Damage from Cell-free DNA in Liquid Biopsies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


NIH_SPENDING_CATS: Asthma;Climate-Related Exposures and Conditions;Clinical Research;Genetics;Lung;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

PHR: Project Narrative This application proposes to define new mechanisms linking maternal exposure to diesel exhaust with predisposition to asthma in offspring. Successful completion of this project has a potential to pave the way for development of new diagnostic, prevention and treatment strategies for asthma.

PI_NAMEs: GORSKA, MAGDALENA MARIA (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Address;Allergens;Allergic;Asthma;asthma model;ATAC-seq;Basophils;Biological Markers;Blood specimen;Bone Marrow;Cell Lineage;Cells;Child;Childhood Asthma;chromatin remodeling;Chronic;cigarette smoke;congenic;cytokine;Data;Development;diagnostic strategy;Diesel Exhaust;early embryonic stage;Embryo;Embryo Transfer;Enhancers;Environment;Environmental Exposure;epidemiology study;experimental study;Exposure to;Female;Future;Generations;Genes;Hematopoiesis;Hematopoietic Stem Cell subsets;Hematopoietic stem cells;high risk;Histamine Release;Human;IgE;IL3 Gene;IL3RA gene;IL4 gene;Immune response;Immune system;imprint;In Vitro;indexing;Injections;Interleukin-3 Receptor;Lead;life span;Link;Lymphoid Cell;Maternal Exposure;maternal serum;Measures;Mediating;meetings;Memory;Modeling;Molecular;Mothers;mouse model;Mus;Myeloid Cells;novel diagnostics;Null Lymphocytes;offspring;overexpression;particle;particle exposure;Pathway interactions;Phenotype;Placenta;placental transfer;Population;Predisposition;pregnant;prevent;Prevention strategy;Process;Production;programs;promoter;PTPRC gene;pup;Radioactivity;Radiolabeled;Regulatory Element;Reporter;Reporting;Risk;Role;self-renewal;Serum;Site;Source;Stem cell transplant;stem cells;synergism;System;Testing;Tissues;transcriptome;transcriptome sequencing;transmission process;treatment strategy;Up-Regulation

PROJECT_TITLE: Maternal programming of the stem cell-basophil axis for asthma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(57)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Physical Activity;Prevention;Rehabilitation

ORG_DEPT: NEUROSCIENCES

PHR: PROJECT NARRATIVE  Using a neuroscientific approach grounded in the pathophysiology of Alzheimer's disease, the proposed study will cross disciplines of neuroscience, health, and technology to investigate the effects of a targeted, simultaneous physical and cognitive activity intervention on brain health and cognition in individuals with early mild cognitive impairment. Results from this study will provide new evidence for a combined intervention to enhance cognition and brain health in older adults at risk for Alzheimer's disease.

PI_NAMEs: PA, JUDY  (contact)

PROGRAM_OFFICER_NAME: HETTINGER, JANE CECELIA

PROJECT_TERMS: 3-Dimensional;active control;Adult;Affect;Alzheimer's Disease;Alzheimer's disease risk;Amyloid;Animals;arm;Behavior;Behavior Therapy;Birth;blood-based biomarker;Brain;brain health;Brain imaging;brain magnetic resonance imaging;Brain-Derived Neurotrophic Factor;cardiovascular fitness;cell motility;Cell Survival;Cells;cerebral atrophy;Clinical Trials;Cognition;Cognitive;cognitive control;cognitive training;comparison control;Control Groups;Coupled;Data;Dementia;Discipline;Disease;educational atmosphere;effective therapy;Environment;executive function;Exercise;exercise intensity;exercise intervention;Exposure to;Functional disorder;Goals;Health;Heart Rate;Hippocampus;Image;Impaired cognition;improved;Individual;Insulin-Like Growth Factor I;interest;Intervention;Intervention Trial;Learning;lifestyle intervention;Literature;Long-Term Potentiation;Maintenance;Measurement;Measures;Memory;Methodology;mild cognitive impairment;moderate-to-vigorous physical activity;neurogenesis;Neurosciences;novel;older adult;Outcome;Participant;Peripheral;Persons;pharmacologic;Phase;Phase II Clinical Trials;Physical activity;physical conditioning;Populations at Risk;Positioning Attribute;Positron-Emission Tomography;post intervention;Prefrontal Cortex;prevent;programs;Publishing;Randomized;recruit;Safety;Series;sobriety;spatial memory;Stimulus;Structure;Supervision;Technology;Testing;Time;Training;Training Programs;treatment effect;Vascular Endothelial Growth Factors;vigorous intensity;virtual environment;virtual reality;virtual reality environment;virtual reality intervention;VO2max;way finding;Work;β-amyloid burden

PROJECT_TITLE: Targeted Physical and Cognitive Activity in a VR Environment in Older Adults at Risk for Alzheimer's Disease


NIH_SPENDING_CATS: Aging;American Indian or Alaska Native;Cardiovascular;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Nutrition;Obesity;Precision Medicine;Racial and Ethnic Minority Health Research;Rural Health

PHR: Project Narrative Aging and age-related cardiometabolic diseases (CMDs) such as obesity, diabetes, cardiovascular disease are the major cause of morbidity and mortality and disproportionately affect American Indians. The human gut flora has emerged as a potential therapeutic target for anti-aging and preventing or treating CMDs. This study is to identify key gut flora features associated with aging and CMDs as well as modifiable factors (e.g., diet, drug, live organisms) that can modulate the effects of gut flora on aging and cardiometabolic risk. Findings of this study may lead to novel, microbiota-based precision strategies for healthy aging and cardiometabolic health, in addition to providing new insights into disease pathogenesis.

PI_NAMEs: ZHAO, JINYING  (contact)

PROGRAM_OFFICER_NAME: GAO, HONGWEI

PROJECT_TERMS: Actinobacteria class;Address;Affect;Age;age acceleration;age related;age-related disease;Aging;aging related;American Indians;Ancillary Study;Animal Model;Antibiotics;Archaea;Bacteria;Bacteroidetes;beneficial microorganism;Biological;Biological Aging;Biological Process;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;Chronic;Chronic Kidney Failure;Clinical;Communities;Complex;Consumption;Contracts;Data;Diabetes Mellitus;Diet;dietary;Disease;Dyslipidemias;Eating;Environmental Risk Factor;Epidemiologic Factors;epidemiology study;Ethnic Population;European ancestry;evidence base;experimental study;Exposure to;fecal transplantation;Firmicutes;Food;Functional disorder;Funding;fungus;Gender;Genetic;genetic makeup;Genome;Geography;gerotherapeutic;glucose metabolism;Goals;gut dysbiosis;gut microbes;gut microbiome;gut microbiota;Health;Health Status;healthy aging;Heart;high risk;high risk population;host microbiome;host-microbe interactions;Human;Hypertension;Immune system;improved;Individual;Inflammation;innovation;insight;Insulin Resistance;Integration Host Factors;Intestines;Investigation;Knowledge;Length;Leukocytes;Life Style;lifestyle factors;Link;Longitudinal cohort;Maps;Medicine;Metabolic;Metabolic Diseases;metagenomic sequencing;Microbe;microbial;microbial signature;microbiome composition;microbiota;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Nature;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Organ;Organism;Parasites;Parents;Participant;Pathogenesis;pathogenic microbe;Pharmaceutical Preparations;Phase;Phenotype;Physiological;Population;Precision therapeutics;preference;prevent;Production;protective factors;Proteobacteria;Research;Reservations;Risk Factors;Role;Shapes;Shotguns;Statistical Data Interpretation;stool sample;Systems Biology;targeted treatment;telomere;Therapeutic Intervention;trait;tribal lands;Twin Studies;Variant;Virus;whole genome;Work

PROJECT_TITLE: Gut microbiome, aging and cardiometabolic diseases in American Indians


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Heterogeneity in cancer cells is a clinically important but poorly understood property of tumors that has the potential to explain tumor growth, treatment relapse, metastasis and other cancer behaviors. This proposal aims to characterize the heterogeneity of proliferating and quiescent cancer cell populations in lung adenocarcinoma and investigate the role of Wnt signaling in maintaining distinct proliferative states. Completion of this research plan will enhance our understanding of the mechanisms tumors use to develop cellular diversity, which may suggest strategies for improving cancer treatment.

PI_NAMEs: TORBORG, STEFAN ROSS (contact)

PROJECT_TERMS: 3-Dimensional;Acyltransferase;Adenocarcinoma Cell;Allografting;Automobile Driving;Basic Science;Behavior;Biological Assay;Biology;cancer cell;Cancer Etiology;cancer stem cell;cancer therapy;cancer type;Cell division;cell growth;Cell Proliferation;Cell Separation;Cells;Cessation of life;Chimeric Proteins;Clinical;Colon Carcinoma;Complex;COVID-19;CRISPR/Cas technology;Data;Disease;Disease Outcome;DNA Repair;Doxycycline;Drug Efflux;effective therapy;efflux pump;Enterobacteria phage P1 Cre recombinase;experimental study;Flow Cytometry;Future;Gene Expression Profile;Gene Modified;Genes;Genetic Transcription;Genetically Engineered Mouse;Goals;Growth;Heterogeneity;High Prevalence;Histologic;Histones;improved;in vivo;Individual;Information Theory;Investigation;Knock-out;Label;Lentivirus Vector;Ligands;Lung Adenocarcinoma;Lung Neoplasms;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Medicine;Methods;mortality;mouse model;Mus;Mutation;Neoplasm Metastasis;novel;Organoids;Oxidative Stress;Pathway interactions;Patients;Phenotype;Population;Porcupines;Prevalence;prevent;Prognosis;Proliferating;Property;Publishing;Recurrent disease;refractory cancer;Relapse;Renal Carcinoma;Research;resilience;Resistance;Role;single cell mRNA sequencing;single-cell RNA sequencing;small hairpin RNA;Sorting;stem;stem cells;stemness;Survival Rate;System;targeted cancer therapy;Testing;Therapeutic;therapeutic target;Tissues;Transplantation;Treatment Failure;tumor;tumor behavior;tumor growth;tumor heterogeneity;tumor progression;Tumor Tissue;tumorigenic;Up-Regulation;vector;Wnt proteins;WNT Signaling Pathway;Work

PROJECT_TITLE: Investigation of heterogeneity in cancer cell proliferation - COVID extension request

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(20)-L]


ORG_CITY: TUSCALOOSA

ORG_NAME: TUSCALOOSA VETERANS AFFAIRS MEDICAL CTR

ORG_STATE: AL

PHR: Improving person-centered care, quality of life, and empowerment of residents and frontline care providers are urgent priorities across national agencies. Montessori Approaches to Person- Centered Care for VA Community Living Centers (MAP-VA) is an innovative intervention that offers practical strategies for progress in ways that engage and motivate frontline staff. Several innovations distinguish it from existing programs: (1) a unique emphasis on Veteran-to-Veteran engagement; (2) teaching staff to facilitate increased meaningful roles for residents; (3) specific tools for assessing resident strengths across varying abilities; (4) fostering environments that support independence; and (5) strategies to address system-level barriers that may stand in the way of providing person-centered care. Evaluation and implementation of MAP-VA has the potential to improve critical clinical outcomes for some of VHA’s most vulnerable Veterans.

PI_NAMEs: HILGEMAN, MICHELLE M. (contact)

PROJECT_TERMS: Address;Adoption;affective disturbance;Aggressive behavior;Aging;Agitation;Anti-Anxiety Agents;Antipsychotic Agents;Assessment tool;Behavior;Behavioral;Behavioral Symptoms;Body Weight decreased;burnout;Caring;Clinical;Cluster randomized trial;cognitive ability;Collaborations;Communities;community living;Complex;Continuity of Patient Care;Data;Data Collection;Data Set;Data Sources;Dementia;depressive symptoms;design;Diagnosis;Distress;Eating;Educational Intervention;Educational process of instructing;Effectiveness;effectiveness evaluation;effectiveness outcome;effectiveness-implementation randomized trial;effectiveness/implementation design;effectiveness/implementation study;effectiveness/implementation trial;Emotional;Employee;empowerment;Environment;Evaluation;Exclusion;fall risk;falls;Female;Fostering;Frontline worker;functional decline;Geriatrics;Home;Hybrids;implementation barriers;implementation evaluation;implementation facilitation;improved;Individual;innovation;Intervention;Interview;Lead;Long-Term Care;Maintenance;Mental Health;Methodology;Modeling;Modernization;Moods;mortality;mortality risk;Movement;Neighborhoods;neuropsychiatric symptom;Nonpharmacologic Therapy;Nursing Homes;Nursing Services;Organizational Culture;Outcome;Pain;Patient Self-Report;person centered;Pharmaceutical Preparations;Pharmacy facility;physical conditioning;Positioning Attribute;preference;Primary Care;Probability;Problem Solving;Process;professional atmosphere;programs;Provider;Proxy;Quality Indicator;Quality of Care;Quality of life;Questionnaires;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recreation;Rehabilitation therapy;Reporting;Research Personnel;Role;Safety;Sampling;Schizophrenia;sedative;severe mental illness;skills;social engagement;Standardization;Stress;success;Suicide prevention;Surveys;System;system-level barriers;Techniques;Testing;theories;Time;Time trend;Training;treatment effect;Trust;urgent care provider;Urinary tract infection;Veterans;Work

PROJECT_TITLE: Montessori Approaches in Person-Centered Care (MAP-VA): An Effectiveness-Implementation Trial in Community Living Centers

STUDY_SECTION_NAME: HSR-6 Aging, Recovery, and Workforce[HSR6]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Women's Health Research

PHR: Project Narrative: This project will determine if leuprolide acetate (Lupron), a drug used in conditions such as prostate cancer and endometriosis, may also be effective against Alzheimer's Disease.

PI_NAMEs: ATWOOD, CRAIG S;BUTLER, TRACY A. (contact);GALVIN, JAMES E

PROGRAM_OFFICER_NAME: CLARKE, AKANNI YAO

PROJECT_TERMS: Acetylcholinesterase Inhibitors;Adult;Aftercare;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer's disease therapy;Alzheimer’s disease biomarker;Amyloid deposition;Animal Model;Antiinflammatory Effect;arterial spin labeling;Atrophic;Biological Markers;Brain region;C-reactive protein;Child;Clinical;clinical efficacy;Clinical Research;Cognition;Cognitive;cognitive performance;Combined Modality Therapy;cost;cytokine;Data;Disease Progression;Dose;Double-Blind Method;Drug usage;Enantone;endometriosis;epidemiology study;Erythrocyte Sedimentation Rate;FDA approved;functional decline;Goals;Gonadal Steroid Hormones;Gonadotropin-Releasing Hormone Analog;gray matter;Hippocampus;IL6 gene;Impaired cognition;improved;Inflammatory;inflammatory marker;Interleukin-1 beta;Investments;Legal patent;Leuprolide Acetate;Luteinizing Hormone;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Malignant neoplasm of prostate;Measures;Motivation;neuroimaging;neuroimaging marker;novel;Patients;Perfusion;Persons;Pharmaceutical Preparations;Pharmacologic Substance;phase 2 study;phase II trial;phase III trial;Placebos;Plasma;pre-clinical;pre-clinical research;Precocious Puberty;preservation;Process;randomized trial;Randomized, Controlled Trials;research and development;response;Serum;Site;Subgroup;tau-1;Therapeutic;Time;TNF gene;United States National Institutes of Health;Uterine Fibroids;Validation;Ventricular;Woman;Work

PROJECT_TITLE: The LUCINDA Trial


ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

ORG_STATE: CA

PHR: The health of older Veterans is an important priority area for VA. Sleep apnea is a common problem in older Veterans that is associated with poor nighttime sleep, more daytime sleepiness, poor functioning and worse quality of life. The recommended first-line therapy for most patients with sleep apnea is positive airway pressure (PAP) therapy; however, over time many patients who begin PAP therapy no longer use it regularly. This study will test the effects of a novel program for improving use of PAP therapy that is specifically designed for older Veterans with insufficient long-term PAP use. If successful, this approach has the potential to improve sleep, function and quality of life in older Veterans with sleep apnea.

PI_NAMEs: ALESSI, CATHY A (contact)

PROJECT_TERMS: Address;Adverse effects;adverse outcome;Aftercare;airway obstruction;Area;attentional control;Attitude;Behavior Therapy;Behavioral;Cardiovascular Diseases;Caring;Chronic;Clinical;clinical practice;comparison control;cost estimate;COVID-19 pandemic;Data;design;Diabetes Mellitus;Diagnosis;Discipline;Disease;Drowsiness;Education;effective intervention;efficacy testing;Equipment;experience;follow-up;Functional impairment;functional outcomes;future implementation;Goals;Health;health related quality of life;Healthcare Systems;High Prevalence;Hour;human old age (65+);Hypertension;Hypoxia;Impaired cognition;implementation outcomes;improved;improvement on sleep;Individual;Information Systems;innovation;Institution;interest;Intervention;Left;Manuals;Measurement;Measures;Mental Depression;Mental Health;Methodology;Modeling;Newly Diagnosed;novel;novel strategies;Obstructive Sleep Apnea;older adult;Outcome;Outcome Measure;outreach;Participant;Patient Outcomes Assessments;Patients;Personal Satisfaction;physical conditioning;pilot test;Pittsburgh Sleep Quality Index;positive airway pressure;Prevalence;primary outcome;programs;Provider;Psychologist;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;remote grading;remote health care;remote monitoring;remote therapy;Reporting;Research;Risk;Self Management;Services;Sleep;Sleep Apnea Syndromes;Sleep Deprivation;Sleep Disorders;Sleep Fragmentations;sleep quality;stroke recovery;Structure;Techniques;telehealth;telemonitoring;Telephone;Testing;Time;tool;treatment as usual;Treatment Efficacy;Veterans;virtual;Work

PROJECT_TITLE: Addressing insufficient positive airway pressure use among older Veterans with obstructive sleep apnea


ORG_CITY: PROVIDENCE

ORG_NAME: PROVIDENCE VA  MEDICAL CENTER

ORG_STATE: RI

PHR: The proposed research is relevant to Veterans because it will provide timely and important information that supports the VA Strategic Goals to provide care that emphasizes Veteran well-being and independence and reduce risk of suicide. Depression in nursing homes is a serious problem that can lead to increased morbidity, mortality, care burden, and cost of care. In Community Living Centers (CLCs; VA nursing homes) the prevalence of depression is nearly 40%. Depression is a major risk factor for suicide. Veterans discharged from CLCs have a substantially higher risk of suicide compared to other VA users of similar age and gender. Treatments for depression using behavioral activation are rarely used in CLCs. This study will provide information on how best to implement an evidence-based behavioral intervention for depression in CLCs that will reduce symptoms of depression and improve Veteran well-being. The results will be immediately and directly relevant to staff and residents of CLCs and will be designed to be useful throughout the VA.

PI_NAMEs: MILLS, WHITNEY L (contact)

PROJECT_TERMS: acceptability and feasibility;Acute;Address;Adoption;Affect;Age;Behavior Therapy;Behavioral;Bite;care burden;care costs;Caring;Clinical;Collaborations;Communication;Communities;community intervention;community living;Competence;Complex;Data;Dedications;depressive symptoms;design;Disease;Dissemination and Implementation;Documentation;Educational Intervention;Effectiveness;Effectiveness of Interventions;effectiveness/implementation study;evidence base;Evidence based intervention;Feeling suicidal;follow-up;foster home;Fostering;functional improvement;Gender;Goals;High Prevalence;high risk;Home;Hybrids;implementation fidelity;implementation framework;implementation measures;implementation strategy;improved;information gathering;innovation;integrated care;Intervention;Language;Long-Term Care;Maintenance;male;Manuals;Measures;Medical;Mental Depression;Mental Health;Mental Health Services;Methods;Modeling;Morbidity - disease rate;mortality;Nursing Homes;nursing intervention;Outcome;Performance;Personal Satisfaction;Persons;Population;post implementation;Preparation;Prevalence;Primary Care;Process;programs;Provider;psychosocial;Public Health;Quality of Care;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recreation;reduce symptoms;Research;Research Personnel;Risk Factors;Risk Reduction;Sampling;satisfaction;severe mental illness;Site;Spottings;Standardization;Substance abuse problem;success;suicidal;suicidal risk;Suicide;Suicide prevention;Support System;System;Teleconferences;Telephone Interviews;Testing;tool;Training;uptake;Veterans;Visit;webinar;Work

PROJECT_TITLE: Implementing the Behavioral Activities Intervention (BE-ACTIV) to Reduce Depression among Veterans in Community Living Centers


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Pediatric;Precision Medicine;Serious Mental Illness

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE This project will evaluate predictive markers of selective serotonin reuptake inhibitor (SSRI) treatment response and side effects (gastrointestinal symptoms and activation) in pediatric patients with anxiety disorders. Currently, there is no way to predict, which youth will respond to SSRIs or who will develop treatment-limiting side effects— a significant concern of patients and their families. The use of extracellular vesicle (EV) lipid and protein cargos as predictors of SSRI treatment response and tolerability in youth is novel with regard to precision medicine and child and adolescent mental health; it has the potential to accelerate treatment selection and increase the safety of SSRIs in pediatric anxiety disorders.

PI_NAMEs: STRAWN, JEFFREY ROBERT (contact)

PROGRAM_OFFICER_NAME: SAMEDY BATES, LESLY

PROJECT_TERMS: Acceleration;Adolescence;Adolescent;adolescent mental health;Adult;Adverse effects;Affect;Age;Agitation;anti-depressive agents;Anxiety Disorders;anxious;Biologic Characteristic;Biological;Biological Markers;biomarker identification;Cells;Central Nervous System Diseases;Ceramides;Child;Child Mental Health;Childhood;childhood anxiety;Clinical;Collection;Data;Development;dihydroceramide;Disease;Disinhibition;Distal;Dose;double-blind placebo controlled trial;DSM-V;Emotional;Escitalopram;Event;extracellular;extracellular vesicles;Family;flexibility;gastrointestinal symptom;generalized anxiety;Goals;Health;Hyperactivity;Impairment;impression;improved;Impulsivity;Intervention;Left;Lipids;Major Depressive Disorder;Mental disorders;Methods;MicroRNAs;Molecular;multiple omics;Neural Cell Adhesion Molecule L1;Neurons;novel;open label;Organelles;Outcome;Outcome Measure;Patients;pediatric patients;Pharmaceutical Preparations;Phosphatidylethanolamine;Phosphatidylinositols;Phosphatidylserines;Physical Sufferings;Physiological Processes;Placebos;Plasma;Plasmalogens;precision medicine;Prediction of Response to Therapy;predictive marker;predictive signature;Predictive Value;Prevalence;Process;prospective;Proteins;psychopharmacologic;psychosocial;Randomized;randomized trial;response;RNA;Safety;Selection for Treatments;Selective Serotonin Reuptake Inhibitor;Separation Anxiety;Sertraline;side effect;Signal Transduction;Site;Sleeplessness;social;Social Anxiety Disorder;success;Symptoms;System;Testing;Time;Titrations;treatment of anxiety disorders;treatment response;Treatment Side Effects;Vesicle;week trial;Youth

PROJECT_TITLE: Estracellular Vesicles as Non-Invasive Predictors of Antidepressant Outcomes in Pediatric Anxiety


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE Colorectal cancer is one of the most incident cancers in the United States. African Americans have higher incidence of colorectal cancer compared to non-Hispanic whites, with worse prognosis. This study will identify biologic pathways that differ in colorectal cancers that arise in African Americans.

PI_NAMEs: PURRINGTON, KRISTEN S.;ROZEK, LAURA  (contact);STOFFEL, ELENA MARTINEZ

PROGRAM_OFFICER_NAME: MOMIN, BEHNOOSH RAMJI

PROJECT_TERMS: African American population;Area;Attention;Behavioral;Biological;Biological Factors;Cancer Burden;cancer health disparity;cancer subtypes;cancer survival;Cancer Survivor;carcinogenicity;Censuses;Characteristics;Chronic;Clinical;clinically relevant;cohort;Colon;colon cancer patients;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;Consensus;Data;Death Rate;deprivation;Diagnosis;Disease;driver mutation;Early Diagnosis;Economic Factors;Environment;Environmental Risk Factor;Epidemiology;Epigenetic Process;Event;exome sequencing;experience;Gene Mutation;Genes;Genetic;genome wide methylation;Genomics;Geographic Locations;Geography;Goals;Grant;health disparity;high risk;Housing;improved;Incidence;Income;indexing;Inflammation;Inflammatory;Louisiana;Malignant Neoplasms;Measures;Mediating;Mediator;Methylation;methylation pattern;metropolitan;Mismatch Repair;Molecular;molecular phenotype;molecular subtypes;mortality;Mutation;Neighborhoods;Not Hispanic or Latino;novel;Outcome;Participant;Pathogenesis;Pathway interactions;Patients;Phenotype;population based;Population Heterogeneity;Prevalence;Prognosis;programs;Race;racial difference;racial disparity;racial diversity;Reporting;Research;Resources;Sample Size;screening;social disparities;Social Environment;social factors;sociodemographics;Socioeconomic Factors;socioeconomics;Somatic Mutation;Testing;tumor;Tumor Biology;tumor microenvironment;tumor registry;Tumor Subtype;Tumor-infiltrating immune cells;tumorigenesis;United States;Work

PROJECT_TITLE: Aggressive colorectal cancer subtypes and social disadvantage in a racially diverse cohort

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-B(55)R]


NIH_SPENDING_CATS: Data Science;Diabetes;Genetics

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: Narrative The AMP-T2D consortium aims to accelerate the pace by which type 2 diabetes (T2D) disease mechanisms are elucidated, through generation and integration of novel genomic datasets. This project will continue to develop the AMP-T2D Knowledge Portal (T2DKP), a public resource of genomic datasets relevant to T2D, its complications, and related traits. Extending this resource will enable AMP-T2D investigators, as well as researchers worldwide, to more easily share genomic datasets and use them to interrogate T2D disease mechanisms.

PI_NAMEs: BOEHNKE, MICHAEL L;BURTT, NOEL P;FLANNICK, JASON  (contact)

PROGRAM_OFFICER_NAME: ZAGHLOUL, NORANN

PROJECT_TERMS: Acceleration;Address;application programming interface;Bioinformatics;Biological;Biology;California;causal variant;Chromosome Mapping;Collaborations;Complex;Computer software;Data;data access;Data Analyses;Data Display;data integration;data portal;Data Set;data visualization;data warehouse;Databases;Development;Disease;Education and Outreach;Ensure;European;federated data;Feedback;Fostering;Foundations;functional genomics;Funding;gene network;Generations;Genes;Genetic;genetic association;genome resource;genomic data;Genomics;Genotype;Goals;human disease;Individual;Infrastructure;Internet;knowledge base;knowledge curation;Knowledge Portal;Link;Medicine;Methods;National Institute of Diabetes and Digestive and Kidney Diseases;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Pattern;phenotypic data;prevent;programs;Protocols documentation;Research Personnel;Resources;response;RFP2 gene;risk variant;software development;Source;Specific qualifier value;Susceptibility Gene;Therapeutic;tool;trait;Transcript;Universities;Update;Variant;Visualization;web interface;web portal

PROJECT_TITLE: The next iteration of the AMP-T2D Knowledge Portal