ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE Trypanosoma brucei and related trypanosomatids are deadly, vector-transmitted pathogens that cause tremendous human suffering and economic burden worldwide. Transmission by insect vectors complicates control efforts and better understanding of pathogen-vector interactions is needed to facilitate novel approaches for preventing transmission. T. brucei cAMP signaling has emerged as critical for enabling transmission by the tsetse fly vector and the current project will define mechanisms of cAMP signaling and chemotaxis in trypanosome-vector interactions, with findings expected to identify candidate targets for transmission-blocking strategies.

PI_NAMEs: HILL, KENT L (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Adenylate Cyclase;Africa South of the Sahara;African;Agriculture;Area;Arthropod Vectors;Binding;Biological Assay;Biology;candidate identification;Chemotaxis;Complex;Country;Cyclic AMP;Data;Development;disease transmission;Economic Burden;Endogenous Factors;endosymbiont;Environment;environmental change;Exhibits;exosome;extracellular;Extracellular Domain;fly;Genes;genetic manipulation;Human;human morbidity;human mortality;In Vitro;Infection;Infection Control;Infection prevention;Insect Vectors;Knowledge;Life Cycle Stages;Ligand Binding Domain;Ligands;Link;Livestock;Mammals;Mediating;Methods;microbiome;Midgut;migration;Modeling;Motility;Movement;multidisciplinary;mutant;novel strategies;Parasite Control;Parasites;pathogen;prevent;Production;Protein Family;Proventriculus;Proxy;receptor;Regulation;Research Personnel;Role;Salivary Glands;Series;Signal Pathway;Signal Transduction;small molecule;social;success;System;Testing;therapeutically effective;Tissues;transcriptome;transcriptomics;transmission blocking;transmission process;transmission-blocking vaccine;Trypanosoma;Trypanosoma brucei brucei;Tsetse Flies;vaccine development;Vaccines;vector;vector transmission;vector-borne;Vector-transmitted infectious disease;Work

PROJECT_TITLE: Trypanosome cAMP signaling mediates parasite-vector interaction

STUDY_SECTION: TVZ

STUDY_SECTION_NAME: Transmission of Vector-Borne and Zoonotic Diseases Study Section [TVZ]


ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: LA JOLLA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Infection with amoeba Naegleria fowleri causes severe primary amoebic meningoencephalitis (PAM). The requirement of brain penetrance makes many drugs inefficient in the treatment of PAM. Our goal is to develop brain-penetrant inhibitors of CYP51 into drug candidates for the treatment of PAM.

PI_NAMEs: DEBNATH, ANJAN  (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Acanthamoeba;Affinity;Amoeba genus;Amphotericin B;analog;Animals;aqueous;Astrocytes;Azoles;Binding;biodefense;Biological;Biological Assay;Biology;blood-brain barrier crossing;blood-brain barrier permeabilization;Brain;Brain Diseases;brain tissue;Buffers;candidate selection;carbonyl group;carboxylate;Categories;Cells;Chemicals;Child;Chlorine;computational chemistry;cytotoxicity;design;Detection;Developed Countries;Development;Disease;Docking;drug candidate;drug discovery;Drug Industry;drug repurposing;Drug Targeting;Eating;economic incentive;Economics;effective intervention;effective therapy;efficacy study;Esters;Ethers;Evaluation;Evidence based treatment;Exhibits;extend lifespan;Fatality rate;FDA approved;Follow-Up Studies;fungicide;Goals;Human;human pathogen;Hydrolysis;improved;In Vitro;in vitro Assay;in vivo;Infection;inhibitor;Intervention;Intestines;Investments;Itraconazole;Kidney;Laboratories;Lead;Liver;member;Meningoencephalitis;Metabolic;Microsomes;Molecular;molecular modeling;mouse model;Naegleria;Naegleria fowleri;National Institute of Allergy and Infectious Disease;Nature;opportunistic pathogen;oxetane;Parasites;pathogenic fungus;Patients;Penetrance;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Plasma;posaconazole;prevent;primary amebic meningoencephalitis;Probability;Property;Rare Diseases;Reporting;Research;Research Personnel;Resistance;Resources;Scheme;Site;small molecule;Solubility;standard of care;Sterol Biosynthesis Pathway;Sterols;Structure;Structure-Activity Relationship;Swimming Pools;Testing;Therapeutic;therapeutic target;Treatment Protocols;Water;young adult

PROJECT_TITLE: Development of brain-penetrant drugs targeting N. fowleri primary amoebic meningoencephalitis (PAM)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-M (81)]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Data Science;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Rare Diseases

ORG_CITY: GALVESTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: Project Narrative:  Early cancer diagnostics is critical because the number of cases is rising, and the chances of  survival increase if caught at an early stage. Currently standard screening examinations often fail  to detect these initial changes, and their challenge is to identify abnormal areas with a high  likelihood of cancer transformation. In this project, we will develop a new approach for detection  that uses large and small imaging with guidance of artificial intelligence methods for consistency  in early cancer diagnostics.

PI_NAMEs: VILLARREAL, PAULA  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Animal Model;Area;Artificial Intelligence;artificial intelligence method;Benign;Biological Markers;Biophotonics;Blinded;Cancer Detection;cancer diagnosis;Cancer Diagnostics;Carcinoma;Clinical;clinical translation;Complement;Complex;complex data;Computerized Medical Record;Data;Data Set;Decision Making;deep learning;Detection;Development;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic strategy;diagnostic value;Disease;Early Diagnosis;Ensure;Epithelium;Evaluation;Exercise;feature extraction;Fellowship;Foundations;Future;Goals;Head and Neck Cancer;Head and neck structure;high risk;Human;human tissue;Image;imaging modality;Imaging Techniques;improved;independent component analysis;Individual;Intraepithelial Neoplasia;Label;Laboratories;Learning;Lesion;Lie Detection;Machine Learning;machine learning algorithm;machine learning method;Malignant - descriptor;Malignant Neoplasms;Medical;Methods;Microscopic;Microscopy;Modality;Modeling;Morphology;Mouth Neoplasms;mouth squamous cell carcinoma;Multi-modal optical imaging;Multimodal Imaging;multimodality;Nature;Neoplasms;neoplastic;novel;novel strategies;Optical Biopsy;optical imaging;Optical Methods;Optics;oral cavity epithelium;Oral Examination;Patients;Performance;Persons;Phase;Postdoctoral Fellow;pre-clinical;Process;Publishing;Records;Research;Sampling;screening;Screening for cancer;Site;Source;Specimen;supervised learning;Survival Rate;System;Techniques;Technology;Texas;Training;United States;Universities;Visualization;Work

PROJECT_TITLE: Data-driven Diagnostics using Multimodal- AI Assisted Approaches for Early Cancer Detection

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-U (M1)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Lung

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Occupational silica dust exposure is linked with the autoimmune diseases rheumatoid arthritis. Although experimental models exist for several silica induced diseases, there is currently no animal model in which silica dust exposure results in arthritis. Our studies show that silica dust exposure results in severe arthritis in the BXD2 mouse strain, providing a novel model to study how silica dust exposure leads to arthritis.

PI_NAMEs: POLLARD, KENNETH MICHAEL (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: ANCA vasculitis;Animal Model;ankle joint;Anti-citrullinated peptide antibody;Antibody Response;Arthritis;Autoantibodies;Autoimmune;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;bone erosion;Cartilage;Chronic;clinically relevant;Connective Tissue Diseases;Coupled;Development;Diagnosis;Disease;Distant;Dust;Environment;Environmental and Occupational Exposure;Environmental Exposure;Epitopes;Event;Experimental Models;Exposure to;Feasibility Studies;Fibrosis;Frequencies;Genetic;Genetic Predisposition to Disease;genetic risk factor;Health;Immunoglobulin G;Immunologics;immunoreaction;Inbred Mouse;Inflammation;Inflammatory;Inflammatory Arthritis;Inflammatory Response;Intra-Articular Injections;Joints;Knee joint;Link;Lung;Mining;Modeling;Molecular;Mouse Strains;mucosal site;Mucous Membrane;Mus;Nature;novel;Nuclear Antigens;Occupational;Occupational Exposure;Occupations;Oral;Organ;particle;Pathogenesis;Pathology;Patients;Phase;Post-Translational Protein Processing;pre-clinical;Predisposition;Process;Production;Public Health;Pulmonary Inflammation;Recombinants;Reporting;response;Rheumatoid Arthritis;Risk;Risk Factors;Serum;Severities;Silicon Dioxide;Silicosis;Site;Sm antigen;Smoking;Surface;Synovitis;systemic autoimmune disease;systemic autoimmunity;Systemic disease;systemic inflammatory response;Systemic Lupus Erythematosus;Systemic Scleroderma;Testing;Tissues;Toxic effect

PROJECT_TITLE: A novel model of severe inflammatory arthritis induced by pulmonary silica exposure

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Diabetes;Regenerative Medicine;Wound Healing and Care

ORG_CITY: IRVINE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Impaired angiogenesis during wound healing is a major clinical challenge in the healing of injured  tissues. The goal of the proposed project is to create a new wound healing treatment that  incorporates apoptotic neutrophils and hydrogels, which together will enhance angiogenic  signaling in the wound environment. The work will open a new strategy to modulate the healing  response following injury.

PI_NAMEs: LIU, WENDY  (contact);PLIKUS, MAKSIM V

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Acute;angiogenesis;Angiogenic Factor;Anti-Inflammatory Agents;Apoptosis;Apoptotic;Autologous;Biocompatible Materials;Blood coagulation;Blood Vessels;cell injury;cell motility;Cell Proliferation;Cell Therapy;Cells;Cellular Infiltrate;Cicatrix;Clinical;Coagulation Process;cytokine;db/db mouse;diabetic;Diabetic mouse;diabetic patient;Disease;Economic Burden;Encapsulated;Endothelial Cells;extracellular vesicles;Flow Cytometry;Gelatin;Goals;Growth Factor;healing;high reward;high risk;Histology;hydrogel scaffold;Hydrogels;Imaging Techniques;Immune;Immunohistochemistry;Impaired wound healing;Impairment;improved;In Situ;In Vitro;Induction of Apoptosis;Infiltration;Inflammation;injured;Injury;Interleukin-10;Investigation;Knowledge;Leukocytes;Macrophage;Matrix Metalloproteinases;Methacrylates;Methods;monocyte;Mus;neutrophil;novel strategies;novel therapeutic intervention;Operative Surgical Procedures;pathogen;Patients;Peptide Hydrolases;Phagocytosis;Pharmaceutical Preparations;Phenotype;Platelet-Derived Growth Factor;Process;Public Health;response;response to injury;revascularization;Role;Serine;Signal Transduction;single-cell RNA sequencing;Site;Skin;skin wound;Skin wound healing;Splint Device;success;Temperature;Testing;Therapeutic Intervention;Thick;Three-Dimensional Imaging;tissue oxygenation;tissue repair;Tissues;transcriptomics;uptake;Vascular Endothelial Growth Factors;Work;wound;wound environment;wound healing;Wound models

PROJECT_TITLE: Delivery of apoptotic neutrophils to improve angiogenesis during wound healing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-X (83)]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Opioids;Prevention;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: RENO

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: Project Narrative To reduce substance-use related harms, we need to provide a suite of harm reduction service delivery approaches that will address the needs of a diverse and evolving population of people who use drugs. In the proposed study we will examine the prevalence of use, and barriers and facilitators of using harm reduction vending machines, a novel element of new US-based harm reduction service delivery modalities. This proposal addresses the NI DA 2022 strategic plan goal to accelerate the science of harm reduction and will be directly and immediately relevant to informing national drug control strategy.

PI_NAMEs: KIRK, MIA RAE (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Acceleration;acceptability and feasibility;Address;Adopted;Age;Area;Awareness;Behavior;behavior change;Behavioral;Behavioral Model;Businesses;Cessation of life;Characteristics;Cities;Code;Communicable Diseases;Communities;community organizations;Country;Data;demographics;Disease Outbreaks;disease transmission;Drug Controls;Drug usage;Drug user;Elements;Environmental Risk Factor;Epidemic;Equipment and supply inventories;Ethnography;experience;fentanyl test;Fright;frontier;Funding;Future;Gender;Geography;Goals;Government;Harm Reduction;Health;Health Services Accessibility;Hepatitis C virus;HIV;homeless shelters;Hospitals;Hour;Human Resources;improved;Injections;innovation;Intention;International;Intervention;Intervention Studies;Interview;Lead;Location;Maps;methamphetamine use;Methods;Modality;Monitor;Naloxone;National Institute of Drug Abuse;Needle-Exchange Programs;Nevada;novel;operation;opioid use;Outcome;Overdose;overdose death;Overdose reduction;overdose risk;Participant;Pattern;Persons;Pharmaceutical Preparations;Planning Theory;Policy Maker;Population;Prevalence;Process;Public Health;Race;Recording of previous events;recruit;reduced substance use;Research;Resources;Respondent;Risk;Risk Reduction;Route;Rural;Sampling;scale up;Schedule;Science;service delivery;Services;Site;social;social cognitive theory;social factors;social stigma;sociodemographics;Strategic Planning;substance use;Surveys;Syringes;Telephone;test strip;theories;Transportation;Underserved Population;United States;Universities;US State;viral transmission;Visit;Vulnerable Populations

PROJECT_TITLE: Harm reduction vending machines: Exploring and improving acceptability of a low barrier approach to reducing drug related harms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (20)]


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_DEPT: CHEMISTRY

PHR: Project Narrative:  Fast 3D imaging techniques are important for biomedical research and clinical diagnostics. This project seeks to  develop a new nonlinear digital microscopic holography approach that can reveal chemical signatures and  structural dynamics of biological specimens with unprecedented speeds. This transformational tool may provide  deep insight into open questions and enable discoveries of disease mechanisms and new treatment paradigms.

PI_NAMEs: GE, NIEN-HUI  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: 3-Dimensional;4D Imaging;Acceleration;Animal Model;animal tissue;Area;Biological;Biological Process;Biomedical Engineering;Biomedical Research;Calcium Oscillations;Calibration;Carbon;Cell Culture Techniques;Cell Physiology;Chemicals;clinical diagnostics;Complex;Cytoplasmic Granules;Detection;detector;Diameter;digital;Dimensions;Disease;Embryonic Heart;experimental study;Fertilization;Film;Fingerprint;Fourier Transform;Frequencies;functional group;Future;Generations;Goals;Grant;Hand;hologram;Holography;Hydrogen;Image;Imaging Techniques;improved;innovation;insight;instrument;Label;Lasers;Light;live cell imaging;Malignant Neoplasms;Maps;Measurement;Measures;Microscope;Microscopic;microscopic imaging;Microscopy;millisecond;Modeling;Molecular;Morphology;multimodality;nanoparticle;National Institute of Biomedical Imaging and Bioengineering;neural circuit;Neurology;Neurons;Noise;novel strategies;Oils;Optics;Organism;Outcome;Performance;Phase;Photons;Physiologic pulse;Process;real-time images;Recovery;Research;Research Personnel;Resolution;response;Sampling;Scanning;second harmonic;Signal Transduction;Source;spatiotemporal;Specimen;Spectrum Analysis;Speed;Starch;Stretching;Structure;submicron;Sum;Techniques;Tendon structure;Three-Dimensional Imaging;Time;Tissue Engineering;Tissue Sample;tool;tumor microenvironment;Validation;Visualization;Work

PROJECT_TITLE: Hyperspectral chemical imaging via sum-frequency generation microscopic holography

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-Y (82)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

PHR: Hazardous drinking is common among Veteran primary care patients and increases risk for more costly and complex medical problems over the long-term. Yet, the vast majority of these Veterans go untreated due to patient, provider, and organizational barriers. By providing an option for care that is easily accessible, private, and self-directed, mobile applications (apps) circumvent many of the often-cited barriers to alcohol use treatment. However, poor patient engagement remains the Achilles’ heel of these apps. Through supportive accountability, Peer Specialists can maximize the reach and engagement of these apps with patients and improve drinking outcomes. If successful, our proposed research has the potential to transform care and increase access to alcohol-related services for Veterans who engage in hazardous drinking but rarely seek treatment, and, in turn, mitigate the adverse health outcomes that stem from untreated hazardous drinking.

PI_NAMEs: BLONIGEN, DANIEL MICHAEL (contact)

PROJECT_TERMS: Accountability;addiction;Adherence;Alcohol abuse;alcohol abuse therapy;alcohol availability;Alcohol consumption;alcohol seeking behavior;Alcohols;brief intervention;care delivery;care systems;Caring;Complex;connected care;cost;Coupled;Data;design;drinking;Drug usage;Effectiveness;effectiveness testing;eHealth;evidence base;Foundations;Gender;Goals;hazardous drinking;Health;Health Services Accessibility;Heavy Drinking;Human;human old age (65+);implementation trial;improved;informant;innovation;Intervention;Interview;Lived experience;Mediating;Mediator;Medical;medical specialties;Mental Health;Mental Health Services;Methodology;mobile application;Modeling;novel;novel strategies;Online Systems;Outcome;patient engagement;patient oriented;Patients;peer;peer support;Pilot Projects;Population;pragmatic trial;Primary Care;primary care patient;primary care visit;primary outcome;Privatization;Provider;psychiatric comorbidity;psychiatric symptom;Randomized;Randomized, Controlled Trials;Readiness;Recommendation;Recovery;recruit;Reporting;Research;Risk;Role;role model;routine screening;satisfaction;Secure;Self Care;Self Direction;Self Efficacy;Self Management;Services;Severities;Site;social stigma;Specialist;standard of care;stem;substance use;Suicide prevention;technological innovation;Telephone;telephone session;Testing;Time;tool;Training;Travel;treatment as usual;Veterans;virtual healthcare;Work

PROJECT_TITLE: Stand Down-Think Before You Drink: An RCT of a Mobile App for Hazardous Drinking with Peer Phone Support

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


ORG_CITY: MINNEAPOLIS

ORG_NAME: MINNEAPOLIS VA  MEDICAL CENTER

ORG_STATE: MN

PHR: Effective psychotherapies for depression are available in VA but are underutilized by therapists working in specialty mental health clinics. Reasons for low use have not been empirically investigated. Findings from research on the implementation of evidence-based psychotherapies for other conditions such as PTSD cannot be fully generalized to depression because depression care is organized differently in VA. In this project, we use an explanatory sequential mixed-methods approach to examine contextual and system factors that impact delivery of evidence-based psychotherapies for depression as well as explore the impact of potential therapist- and patient-level factors. Findings will inform an intervention framework that will help our partners and stakeholders in the field to prioritize barriers on which to intervene and identify promising solutions.

PI_NAMEs: ACKLAND, PRINCESS E. (contact)

PROJECT_TERMS: Address;Adjustment Disorders;administrative database;Attitude;Behavior Therapy;burden of illness;care delivery;Caring;chronic pain;Classification;Clinic;clinical implementation;Clinical Practice Guideline;Cognitive Therapy;Coin;Competence;Consultations;Data;Dedications;Depressed mood;Depressive disorder;design;Development;Economic Burden;Effectiveness;Evaluation;evidence base;evidence based guidelines;experience;Feeling suicidal;Goals;Guidelines;Health system;Homogeneously Staining Region;innovation;interpersonal therapy;Intervention;intervention mapping;Interview;Investigation;Leadership;Learning;Major Depressive Disorder;Medical center;medical specialties;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Methodology;Methods;Modeling;multiple data sources;Occupational;Patients;Perception;physical conditioning;Policies;Post-Traumatic Stress Disorders;Process;Program Evaluation;Provider;provider-level barriers;Psychotherapy;Quality of life;Random Allocation;Recommendation;Recurrence;reducing suicide;Research;Resources;Risk Factors;Schedule;Site;Sleep Disorders;Specific qualifier value;statistics;Structure;Substance abuse problem;Suicide;Suicide prevention;System;theories;Training;training data;Training Programs;translational study;Veterans;Visual

PROJECT_TITLE: From Training to Practice: Understanding the Integration of Evidence-Based Psychotherapies for Depression (INTEGRATE)


ADMINISTERING_IC: MH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences;Pediatric

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Crosstalk between immune cells and brain-resident cells such as neurons and glia occurs both in healthy conditions and during the progression of neurodevelopmental diseases such as autism and schizophrenia. This proposal seeks to understand the role of a unique population of mast cells next to the developing hippocampus and its potential for driving proper neurodevelopment. Unraveling the complexities of these interactions during normal developmental stages can lead to a better understanding of how neuroimmune interactions can be altered in disease.

PI_NAMEs: MAXIMOVA, ANNA ARKADIEVNA (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Allergic Disease;Antihistamines;Aorta;autism spectrum disorder;Automobile Driving;Axon;Back;Bone Marrow;Brain;brain parenchyma;career;Cell Degranulation;Cells;Central Nervous System;Comprehension;Connective Tissue;critical developmental period;critical period;Curiosities;cytokine;Cytoplasmic Granules;defined contribution;Dendritic Spines;density;dentate gyrus;Development;Disease;Disease Progression;Embryo;Embryonic Development;Etiology;experimental study;Flow Cytometry;Foundations;Genes;Goals;Growth Factor;Hematopoiesis;Hematopoietic;Hippocampus;Histamine;Histamine Release;Host Defense;Hypersensitivity;Immune;Immune signaling;Immune system;Immunologist;inducible Cre;Infection;Infiltration;Inflammation;Injury;Investigation;lateral line;lateral ventricle;Life;Link;Maps;mast cell;mastocytosis;Mediating;Mediator;Mentorship;Mesonephric structure;Microglia;Modeling;Mucous Membrane;Mus;myelination;Myeloid Cells;nervous system development;neural circuit;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;Neuroglia;Neuroimmune;neuroimmunology;Neurologic Process;Neurons;Ontology;Parasitic Diseases;Pathologic;Pattern;Pediatric Neurology;Peripheral;Physicians;Physiological;Play;Population;Population Sizes;postnatal;Preoptic Areas;Process;Proliferating;Rattus;Rodent;Role;Schizophrenia;Scientist;Signal Transduction;Source;Structure;Supporting Cell;Synapses;synaptogenesis;System;Testing;Time;tissue repair;Tissues;Training;Transcript;transcriptome sequencing;Transgenic Mice;Yolk Sac

PROJECT_TITLE: A unique peri-hippocampal mast cell population drives neurodevelopment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F03A-E(20)]


ORG_CITY: BRONX

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE Older Veterans, particularly those with multiple chronic conditions requiring complex medication regimens, are more susceptible to adverse effects of medications. In this study, we examine the effect of a pharmacist led medication management intervention delivered by home televisit on improving medication use. We anticipate that a pharmacist led medication management intervention will lead to reduction in medication discrepancies and inappropriate use, increased medication adherence and reduced adverse drug events in older adults compared to those without the intervention and receiving usual care. Findings will enhance our understanding of methods to improve medication use in older adults, and have the potential to disseminate across VHA.

PI_NAMEs: HUNG, WILLIAM W.,MPH, MD (contact);MOO, LAUREN R

PROJECT_TERMS: Adherence;Adverse drug event;Adverse effects;Caring;Chronic Disease;Client satisfaction;Clinic;Clinical;Clinical Pharmacists;Complex;Data;design;Drug Interactions;Drug usage;Education;Effectiveness;effectiveness evaluation;effectiveness/implementation study;future implementation;Home;Hybrids;implementation evaluation;Improve Access;improved;information gathering;Intervention;Interview;Long-Term Care;Measures;medication compliance;Medication Management;medication nonadherence;Methods;multiple chronic conditions;Non-Prescription Drugs;older adult;Older Population;Outcome;Patients;Persons;Pharmaceutical Preparations;Pharmacists;Pharmacy facility;post intervention;Predisposition;primary outcome;Procedures;Protocols documentation;Provider;Quality of Care;Questionnaires;randomized trial;Randomized, Controlled Trials;Regimen;Research Design;Research Personnel;Respondent;Right to Treatments;Screening procedure;secondary outcome;Site;Structure;success;telehealth;Telemedicine;televisit;treatment as usual;uptake;Veterans;video visit;Visit;Visualization;Writing

PROJECT_TITLE: Effect of Medication Management at Home via Pharmacy Home Televisits

STUDY_SECTION_NAME: HSR-6 Aging, Recovery, and Workforce[HSR6]


ORG_CITY: BEDFORD

ORG_NAME: EDITH NOURSE  ROGERS MEMORIAL VETERANS HOSPITAL

ORG_STATE: MA

PHR: Type 2 Diabetes is a common, complex health condition which can result in many serious and costly health complications if not treated and controlled properly. Overall, 24% of Veterans are diagnosed with Type 2 Diabetes. Vulnerable Veterans, such as minority, low-income, or rural Veterans, and Veterans with comorbid mental health diagnoses, are disproportionately affected and are less likely to have their diabetes under control. One way to help Veterans improve their diabetes control is through the use of technology to help provide information, motivation, and reminders necessary to support diabetes self-management. This study seeks to leverage “Annie”, a new VA texting system. The study will seek input from vulnerable Veteran groups living with diabetes to help develop DD-TXT, a new customizable, interactive texting intervention that allows Veterans to choose what kinds of diabetes self-management support they need, and when. It will compare DD- TXT with another education-only texting intervention called DSE that is based on a diabetes skills workbook.

PI_NAMEs: SHIMADA, STEPHANIE LEAH (contact)

PROJECT_TERMS: Address;Adherence;Affect;African American;Appointment;Area;Behavior;Blood Glucose;blood pressure control;Blood Pressure Monitors;Cellular Phone;Chicago;Chronic Disease;comorbidity;comparative effectiveness;comparative effectiveness trial;Complex;complex chronic conditions;connected care;coping;cost;Data;design;Development;diabetes control;diabetes distress;Diabetes Mellitus;diabetes self-management;diabetic;Diagnosis;digital divide;Disease;Disparity;Education;Effectiveness;effectiveness evaluation;Emotional;empowerment;Evaluation;experience;Feedback;field study;Future;future implementation;General Population;Glycosylated hemoglobin A;Goals;Guidelines;Health;health care availability;Health Care Costs;health equity;Health Expenditures;Health Services Accessibility;Healthcare;Heart;Heterogeneity;Hybrids;implementation strategy;implementation trial;Improve Access;improved;individual patient;Informatics;information gathering;innovation;Intervention;Lead;Libraries;literacy;Logic;Low income;Low-Density Lipoproteins;medical complication;medication compliance;Medication Management;Medicine;member;Mental Health;Methodology;Minority;Modality;Monitor;Morbidity - disease rate;mortality;Motivation;multidisciplinary;Names;Non-Insulin-Dependent Diabetes Mellitus;Nurses;nutrition;Outcome;Ownership;Participant;patient engagement;Patient Preferences;Patient Selection;Patient Self-Report;Patient-Centered Care;Patients;Pharmaceutical Preparations;Physical activity;Physiological;population health;preference;Preventive care;primary care practice;primary outcome;Problem Solving;Process;protocol development;Protocols documentation;Provider;Randomized;Recommendation;Research Priority;Resources;Risk Factors;Rural;Safety;secondary outcome;Self Efficacy;Self Management;self-management program;skills;social health determinants;sociodemographics;Subgroup;success;System;Technology;technology platform;Testing;Text;Text Messaging;text messaging intervention;texting support;Time;treatment as usual;treatment effect;Veterans;virtual;virtual healthcare;Weight maintenance regimen;Woman;Women's Health;Work

PROJECT_TITLE: Diabetes Disparities: Texting to Extend Treatment (DD-TXT)

STUDY_SECTION_NAME: HSR-3 Healthcare Informatics[HSR3]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Fentanyl Misuse and Addiction;Lung;Neurosciences;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Substance Misuse

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: NARRATIVE Ultrapotent synthetic opioids, like fentanyl, are highly toxic agents that pose a significant public health risk and can cause near-immediate cardiorespiratory collapse requiring resuscitative action. This proposal aims to provide resolution into the cardiopulmonary and neurophysiological outcomes following resuscitation from fentanyl-induced cardiorespiratory collapse. We will examine mechanisms contributing to reperfusion injury and test how targeting such mechanisms during reversal of fentanyl-induced cardiorespiratory collapse affects survival and physiological outcomes.

PI_NAMEs: GARCIA, ALFREDO J (contact);SHARP, WILLARD WILLIAM

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: Accidents;Acute;addiction;Address;Aerobic;Affect;Biological Markers;Body System;Brain;Brain Hypoxia-Ischemia;Breathing;Cardiopulmonary;cardiopulmonary system;Centers for Disease Control and Prevention (U.S.);Cessation of life;Child;Circulation;Clinical;Collaborations;Complex;Consumption;Day Care;Development;Dose;Edema;efficacy testing;Exposure to;Fentanyl;fentanyl exposure;fentanyl overdose;Fiber;Functional disorder;glucose metabolism;Heart;HIF1A gene;Hypoxia;Impairment;improved;improved outcome;in vivo imaging;Injury;interest;Investigation;Knowledge;Link;Lung;lung injury;Mediating;Metabolic stress;Mitochondria;Modeling;Molecular Biology;Morbidity - disease rate;mortality;Naloxone;Nature;neurophysiology;novel;Opiate Addiction;Opioid;opioid epidemic;opioid exposure;opioid overdose;Organ;Outcome;Overdose;overdose risk;Oxygen Consumption;Photometry;Physiological;Pilot Projects;Plethysmography;Pre-Clinical Model;prevent;Production;Property;Public Health;Pulmonary Edema;Reperfusion Injury;Resolution;respiratory;response;Resuscitation;Risk;Scientist;Signal Transduction;synthetic opioid;System;Testing;Time;Tissues;United States;ventilation;Ventilatory Depression;weapons

PROJECT_TITLE: Investigating the mechanistic consequences of fentanyl-induced hypoxia and cardiorespiratory collapse

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 LXF-N (M1)]


ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE We propose to develop an advanced imaging technique for deep tissue imaging. The proposed technique will allow better understanding of organ functions and disease progression.

PI_NAMEs: DING, JUN ;PENG, LEILEI  (contact)

PROJECT_TERMS: 3-Dimensional;absorption;Address;Brain;Cell Culture Techniques;Cells;cellular imaging;Color;Complex;Computer software;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Detection;Development;Device or Instrument Development;Dimensions;Disease Progression;Electronics;Energy Transfer;Face;Fluorescence;fluorescence lifetime imaging;Fostering;FPS-FES Oncogene;Functional Imaging;Holography;Image;Imaging Device;imaging modality;imaging study;Imaging Techniques;in vivo;in vivo imaging;industry partner;innovation;instrument;interest;Kidney;kidney cell;Label;Lateral;lens;Light;light curve;light intensity;light microscopy;Lighting;lightspeed;Location;Methods;microscopic imaging;Microscopy;Mus;neural;neuroimaging;Neurophysiology - biologic function;novel;open source;operation;Optics;Organ;Organism;Phase;Phosphotransferases;Process;ratiometric;Records;Research;Resolution;Scanning;sensor;Signal Transduction;Slice;spatiotemporal;Speed;stereoscopic;Structure;Subcellular structure;submicron;System;Techniques;Testing;Three-Dimensional Image;Three-Dimensional Imaging;Time;Tissue imaging;Tissues;tool;two-photon;voltage;Work;Zebrafish

PROJECT_TITLE: Fast Multi-Functional 3D Imaging of Cellular Activities in Deep Tissue

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Autism;Brain Disorders;Clinical Research;Dementia;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PROVIDENCE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE The proposed research is relevant to public health, as we will define endolysosomal mechanisms in the context of childhood developmental and neurodegenerative disease. Endolysosomal dysfunction is a critical feature in neurogenetic diseases, as well as more common diseases such as: Lysosome Disorders, Alzheimer’s Disease (AD) and AD-Related Dementias (ADRD), including tauopathies; autism and related intellectual disabilities. A fuller understanding of mechanisms that protect the endolysosomal system may aid in developing new therapeutics for these diseases.

PI_NAMEs: MORROW, ERIC M (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Affect;Age;Alzheimer's Disease;Alzheimer's disease related dementia;Astrocytes;autism spectrum disorder;Axon;Axonal Transport;Behavioral;bench to bedside;Biological;biomarker development;Brain;Brain Diseases;Cells;Childhood;Christianson syndrome;Data;Defect;Degenerative Disorder;Development;Developmental Delay Disorders;developmental disease;Disease;Disease Progression;Endosomes;Enzymes;exosome;Experimental Models;Family;Female;Functional disorder;gene network;Genes;Genetic Diseases;Genetic study;glial activation;GTPase-Activating Proteins;Heterozygote;human stem cells;In Vitro;in vivo;induced pluripotent stem cell;innovation;Intellectual functioning disability;International;knock-down;Knowledge;late endosome;Lead;Link;loss of function mutation;Lysosomes;male;Mediating;Microglia;Molecular;mosaic;Mosaicism;Mus;Mutagenesis;mutant;Mutant Strains Mice;Mutation;mutation carrier;Natural History;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neurogenetics;neuron development;Neurons;new therapeutic target;novel therapeutics;Outcomes Research;Pathogenesis;Pathogenicity;Pathology;patient derived induced pluripotent stem cells;patient oriented research;Patients;Phenotype;Positioning Attribute;Process;Proteomics;Protons;Public Health;rab7 protein;Rattus;Research;Resources;response;Role;Signal Transduction;single nucleus RNA-sequencing;skill acquisition;Subgroup;Syndrome;System;tau Proteins;Tauopathies;Testing;therapy development;Toxic effect;trafficking;translational approach;Work;X Inactivation

PROJECT_TITLE: Pathogenic Mechanisms in Christianson Syndrome and NHE6-Related Disorders

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Cancer;Neurosciences;Skin Cancer

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Cancer heterogeneity, the influence of the tumor microenvironment, and the mechanisms which contribute to tumor dissemination and morbidity remain to be elucidated. Defining and understanding these mechanisms will facilitate cancer therapies and patient outcomes. This training proposal aims to clarify the roles of the brain- enriched E3 ubiquitin ligase TRIM9 in melanoma and define pathways in the interactions between neurons and cancer that influence tumor progression.

PI_NAMEs: LUKASIK, KIMBERLY  (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Actins;Address;Adhesions;Affect;Axon;axon guidance;Binding;Biochemistry;Biological Assay;Brain;Cancer Biology;cancer cell;cancer heterogeneity;cancer therapy;Cancerous;career;Cell Communication;Cell Cycle Progression;Cell Line;cell motility;Cell Proliferation;Cell Size;cell type;Cells;Cellular biology;Cellular Morphology;Characteristics;Coculture Techniques;Complex;CRISPR/Cas technology;Cytoskeleton;Data;Development;differential expression;Ear;Environment;Exocytosis;experimental study;extracellular;Filopodia;Focal Adhesions;follow-up;Genes;Genetic Engineering;Goals;Heterogeneity;Immune;Immunoprecipitation;In Vitro;in vivo;interest;Invaded;Knock-out;laboratory experience;Laboratory Finding;Lysosomes;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;melanocyte;Melanoma;Melanoma Cell;Melanoma patient;Membrane;Metalloproteases;Metastatic Melanoma;Microscopy;migration;Molecular;Molecular Biology Techniques;Morbidity - disease rate;Morphology;Motility;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;Nerve;Neural Crest;Neurobiology;Neurons;Neurosciences;Ontology;Pathway interactions;Patient-Focused Outcomes;Patients;paxillin;Peptide Hydrolases;Phase;Phenotype;Polymerase;post-doctoral training;Post-Translational Protein Processing;Postdoctoral Fellow;pre-doctoral;prevent;Prognosis;Proliferating;Proteins;Proteomics;Research;Research Proposals;response;Role;Sampling;Shapes;Signal Transduction;Site;skills;small cell lung carcinoma;SNAP receptor;Subcellular structure;Techniques;Testing;therapy outcome;trafficking;Training;tumor;tumor growth;tumor microenvironment;tumor progression;tumorigenesis;ubiquitin-protein ligase;Ubiquitination;vasodilator-stimulated phosphoprotein;Work;ZYX gene

PROJECT_TITLE: The interface of neurons and cancer


NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: NARRATIVE Mutations in ASH1L are a major cause of autism spectrum disorder (ASD) when these genetic changes impair protein function. The ASH1L transcription factor is a protein that regulates large groups of genes simultaneously, including other autism genes. Our goals in this proposal are 1) identify cellular defects in human neurons with patient mutations in ASH1L using iPSC-derived experimental systems, 2) study the functional and circuit defects associated with ASH1L deficiency, and 3) identify the epigenetic and transcriptional signatures associated with ASH1L using mouse and human experimental systems. For all of these Aims, we will rescue the phenotypes identified using a mechanistic approach.

PI_NAMEs: LIU, JUDY SHIH-HWA;LIZARRAGA, SOFIA BEATRIZ (contact)

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: Affect;ASH1L gene;ATAC-seq;autism spectrum disorder;Bioinformatics;Biology;Brain;cell type;Cells;ChIP-seq;Chromatin;Chromatin Remodeling Factor;confocal imaging;Corpus Callosum;Data;Defect;density;derepression;Development;Developmental Gene;Disease;Electrocorticogram;Electrophysiology (science);Epigenetic Process;FOXP1 gene;Functional disorder;Gene Expression Profile;gene network;gene repression;Genes;Genetic Predisposition to Disease;Genetic Research;genetic risk factor;Genetic Transcription;genome editing;Goals;high risk;histone methyltransferase;Histones;Human;human stem cells;imaging approach;Impairment;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;innovation;interdisciplinary approach;Intervention;Link;Mediating;Molecular;Morphogenesis;multi-electrode arrays;Mus;Mutant Strains Mice;Mutation;neural;Neuroanatomy;neurodevelopment;Neurodevelopmental Disorder;neuron development;Neuronal Dysfunction;neuronal excitability;Neurons;Neurosciences;novel;novel therapeutic intervention;patch clamp;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Phenotype;Polycomb;Positioning Attribute;pre-clinical;programs;protein expression;protein function;Proteins;Repressor Proteins;Research;Risk Factors;risk variant;Rodent;Role;single-cell RNA sequencing;Slice;Structure;Synapses;synaptic function;System;Testing;Therapeutic;therapeutic target;transcription factor;Transferase;translational approach;treatment strategy;Work

PROJECT_TITLE: ASH1L mediated transcription networks in autism spectrum disorders


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Prevention

ORG_CITY: PITTSBURGH

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative This research program addresses critical research gaps in understanding the challenges and supportive care needs of nurses with cancer as they return to work (RTW). Nurses and all other healthcare workers play a pivotal role in the healthcare system and population health, and given nurses’ substantial cancer risks and the significance of a successful RTW on cancer survivors’ health-related quality of life (HRQOL), this study aims to clarify intervention targets and develop a tailored mobile health intervention with human-centered design principles to support healthcare works to RTW. This study aligns with the goal of cancer survivorship research to improve cancer survivors’ RTW and HRQOL and provide appropriate support to the healthcare workforce.

PI_NAMEs: YOU, KAI-LIN  (contact)

PROJECT_TERMS: Address;Advocate;Behavior;cancer diagnosis;cancer risk;Cancer Survivor;Cancer Survivorship;cancer type;care recipients;career;Clinical;Colorectal Cancer;Cross-Sectional Studies;Development;Diagnosis;Discipline of Nursing;efficacy testing;emotional distress;Emotions;Employee;empowerment;Ensure;experience;Expert Opinion;Exposure to;Feedback;Focus Groups;Foundations;Goals;Health;Health Care Sector;Health Personnel;health related quality of life;Healthcare;Healthcare Systems;human centered design;improved;insight;Intervention;intervention refinement;Interview;Investigation;Knowledge;Licensing;Literature;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;meetings;mHealth;mhealth interventions;Modeling;Normalcy;Nurse's Role;Nurses;Nursing Diagnosis;occupational hazard;Outcome;Patient Care;Patient Self-Report;Patients;Personal Satisfaction;Phase;Play;Poison;population health;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;pre-doctoral;preservation;Privacy;programs;prototype;recruit;Research;Research Training;Risk;Role;Sampling;Self Assessment;Series;shift work;Supportive care;Surveys;Symptom Burden;Symptoms;therapy development;Training;Treatment Efficacy;unhealthy lifestyle;United States;Universities;usability;Work;Workplace

PROJECT_TITLE: Return-to-work issues in healthcare workers diagnosed with cancer: Investigation and Intervention Development


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Prevention

ORG_CITY: TALLAHASSEE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: This project will use engage the community to understand what is needed to improve HIV testing and HIV prevention in young people in North Florida. It will use new methods and publicly available data to inform future studies to end the epidemic by improving testing and prevention.

PI_NAMEs: HE, ZHE ;NAAR, SYLVIE  (contact)

PROGRAM_OFFICER_NAME: SCOTT-SHELDON, LORI ANN JENNIFER

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adult;age group;AIDS prevention;anti-racism;Back;Behavioral Sciences;Benchmarking;Caring;Clinical Research;Communication;Communities;community engagement;Community Health;community partners;community partnership;Computational Science;County;Data;data integration;Data Science;Deep South;design;Development;Diagnosis;Disparity;efficacious intervention;emerging adult;Ensure;Epidemic;Evaluation;Evidence based intervention;experience;Feeds;Florida;Future;future implementation;Health;Health system;Healthcare;high reward;high risk;HIV;Human immunodeficiency virus test;implementation intervention;implementation outcomes;implementation science;implementation strategy;implementation trial;improved;Informatics;insight;Institute of Medicine (U.S.);Intervention;Knowledge;Learning;Maps;Methods;model building;Modeling;models and simulation;Monitor;Outcome;Outcome Measure;Persons;Phase;Phase Transition;Population;pragmatic trial;pre-exposure prophylaxis;Prevalence;prevent;Prevention;Process;programs;Research Activity;Resources;Role;Science;simulation;Site;Specific qualifier value;System;Testing;therapy development;tool;Translating;translational model;transmission process;Trust;United States National Institutes of Health;Universities;uptake;Youth

PROJECT_TITLE: Precision HIV Prevention: Piloting a youth learning health community

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-L (06)]


NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Lack of durable CD8+ T-cell response to produce inflammatory cytokines upon tumor infiltration remains a barrier to immunotherapy for most cancer patients, prompting the need for a deeper understanding of how T-cells rapidly become dysfunctional. My predoctoral research will delve into how environmental amino acid depletion drives the loss of protein synthesis and cytokine production in tumor-infiltrating T-cells. Furthermore, my postdoctoral research will delve into non-coding-RNA-mediated translational suppression during terminal T-cell exhaustion, unveiling distinct dysfunctional mechanisms during early and late tumor infiltration and justifying metabolic interventions that enhance intracellular AA availability in T-cells to enhance the potency of immunotherapy.

PI_NAMEs: CHEN, YAN-TING  (contact)

PROJECT_TERMS: amino acid metabolism;Amino Acid Transporter;Amino Acids;anti-cancer research;antigen-specific T cells;Antigens;Attenuated;Automobile Driving;Biological Assay;cancer infiltrating T cells;Cancer Patient;career development;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Cellular immunotherapy;chimeric antigen receptor;Chronic;Clinical;cytokine;Cytokine Suppression;cytotoxic;Cytotoxic T-Lymphocytes;cytotoxicity;Data;deprivation;Development Plans;effector T cell;Elements;Environment;Epigenetic Process;exhaust;exhaustion;Exhibits;experience;extracellular;Failure;Fibroblasts;Functional disorder;Genes;genetic signature;Genetic Transcription;Glutamine;Goals;graduate school;Homeostasis;Immune;immune checkpoint;immune checkpoint blockade;Immunosuppression;Immunotherapy;Impairment;improved;in vivo;Individual;Infiltration;Inflammatory;insight;Intervention;Intrinsic factor;Joints;Malignant Neoplasms;Mediating;Memorial Sloan-Kettering Cancer Center;Mentorship;Metabolic;Micronutrients;mRNA Translation;notch protein;novel;novel strategies;Nuclear;Nutrient;overexpression;patient subsets;Patients;Play;Postdoctoral Fellow;posttranscriptional;pre-doctoral;Production;Protein Biosynthesis;Proteins;Proteome;Receptor Signaling;Research;research and development;Research Project Grants;Resistance;Resources;response;Ribosomal RNA;Ribosomes;Role;Small RNA;success;T cell differentiation;T cell response;T cell therapy;T-Cell Receptor;T-Lymphocyte;Training;Transcript;transcriptomics;Transfer RNA;Translations;tumor;Tumor Immunity;tumor microenvironment;Tumor Subtype;Untranslated RNA;Up-Regulation;Work

PROJECT_TITLE: Identifying and Targeting Drivers of Impaired Translation in Tumor-infiltrating CD8+ T-cells.


NIH_SPENDING_CATS: Bioengineering;Cancer;Digestive Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pancreatic Cancer;Precision Medicine;Rare Diseases

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: A novel computational imaging algorithm that combines principles of light matter interaction and information theory to characterize the mechanobiology of three-dimensional whole slide tumor microenvironments, which is important for understanding cancer development, its metastasis and its response to therapy. The input to the algorithm is Hematoxylin and Eosin brightfield images capturing the tissue structure, and multiplexed immunofluorescence images spatially profiling the molecules and cellular diversity of interest.

PI_NAMEs: UTTAM, SHIKHAR  (contact)

PROGRAM_OFFICER_NAME: MILLER, DAVID J

PROJECT_TERMS: 3-Dimensional;Algorithms;Animal Model;anti-cancer research;Atlases;Automobile Driving;beta catenin;Biochemical;Biological;biological heterogeneity;Biological Markers;Biomedical Engineering;Cancer Etiology;Cancer Model;Cancer Prognosis;cancer risk;cancer therapy;Cells;Cessation of life;Clinical;Communication;Computing Methodologies;Development;Diagnosis;Diagnostic;digital pathology;Entropy;Environment;Evolution;feature extraction;Fibrosis;Future;Growth;Hematoxylin and Eosin Staining Method;Homeostasis;Image;Image Analysis;imaging modality;Immunofluorescence Immunologic;Immunofluorescence Microscopy;improved;In Situ;Individual;individual patient;Information Theory;insight;interest;Knowledge;Lesion;Light;Machine Learning;Malignant Neoplasms;mechanical properties;mechanical signal;Mechanics;mechanotransduction;Mediating;men;method development;Methods;microphysiology system;Modeling;Mucinous;Mucinous Neoplasm;nanoscale;Neighborhoods;Neoplasm Metastasis;novel;Optics;Organoids;Outcome;Pancreatic Ductal Adenocarcinoma;pancreatic neoplasm;Papillary;Pathologist;Pathology;pathology imaging;Pathway interactions;Patients;Pharmacotherapy;Phase;Play;pre-clinical;predictive marker;Probability;Process;prognostic;Property;Publishing;Pythons;Relapse;Research Personnel;Resolution;Risk;Role;Signal Transduction;Slide;Specimen;Stains;Structure;Survival Rate;Systems Biology;temporal measurement;therapy resistant;Time;Tissue Sample;Tissues;Translations;treatment response;tumor;tumor microenvironment;WNT Signaling Pathway;Woman;Work

PROJECT_TITLE: Methods for characterizing mechanobiology of the tumor microenvironment landscape

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-5 (M1)]


NIH_SPENDING_CATS: Aging;Bioengineering;Cancer;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prostate Cancer;Urologic Diseases

PHR: Project Narrative Stainless staining of tissue biopsy images and subsequent tumor segmentation by deep learning models is a rapidly emerging technology for cancer research and histopathology diagnoses. We will develop new methods and algorithms to generate knowledge-driven visualization and pixel-by-pixel explanations from clinically validated deep learning models for virtual and chemical H&E and IHC staining to characterize cellular phenotypes for cancer research and accelerate histopathology diagnoses.

PI_NAMEs: SHAH, PRATIK  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Acceleration;Adoption;Agreement;Algorithms;anti-cancer research;Architecture;Atrophic;automated algorithm;Benign;Biological Markers;Biopsy;Biopsy Specimen;Black Box;Board Certification;cancer diagnosis;cancer type;Categories;Cause of Death;Cells;Chemicals;Clinical;clinical application;clinical database;Code;Communication;Computer Models;Computer software;Consensus;Core Biopsy;deep learning;deep learning algorithm;deep learning model;deep neural network;Diagnosis;digital;digital models;Disease;Dropout;Dyes;Emerging Technologies;Evaluation;experience;generative adversarial network;Gland;Gleason Grade for Prostate Cancer;Goals;Guidelines;Hematoxylin and Eosin Staining Method;Histologic;Histopathology;Image;Image Analysis;image translation;imaging biomarker;Immunohistochemistry;Individual;Kidney;Knowledge;Label;Malignant - descriptor;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Measurement;Medical Imaging;Methods;Mission;Mixed Neoplasm;Modeling;Molecular Profiling;Morphology;Needle biopsy procedure;neural;neural network;Neural Network Simulation;novel;Oncology;open source;Outcome;Output;Pathologic;Pathologist;Pattern;Performance;Phenotype;Physicians;Process;Proliferating;Prostate;prostate biopsy;Prostatic Neoplasms;provider adoption;PTEN gene;public database;Publishing;Recommendation;Reporting;Research;Research Personnel;Resolution;screening;Seminal Vesicles;Skin Cancer;Slide;Software Tools;Stains;standard of care;supervised learning;System;Techniques;Tissue Stains;Tissues;tool;Training;training data;Transitional Cell Carcinoma;Translation Process;tumor;tumor diagnosis;Uncertainty;United States;Variant;virtual;virtual imaging;virtual model;Visualization

PROJECT_TITLE: Virtual Digital Histopathology with Explainable Deep Learning for Prostate Cancer Diagnosis


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Effects of Household Energy Combustion;Health Effects of Indoor Air Pollution;Lung;Pediatric;Prevention;Social Determinants of Health

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: NARRATIVE Project Title: Long-term Effects of a household Air Pollution intervention: Follow-up of a randomized controlled trial This proposal seeks to evaluate the long-term effects of an 18-month clean fuel intervention in Puno, Peru, on lung function, cardiovascular disease risk and neurodevelopmental outcomes in children. We will measure clinical outcomes, kitchen concentrations and personal exposures to PM2.5 once yearly and monitor biomass stoves continuously throughout the study period. We will examine whether health outcomes of intervention participants differ to those from control households through the child’s eighth birthday and conduct exposure- response analyses based on the PM2.5 exposure and stove use data during the intervention and subsequent follow-up period.

PI_NAMEs: CHECKLEY, WILLIAM  (contact);NICOLAOU, LAURA

PROGRAM_OFFICER_NAME: BRUNO, FERNANDO PEREIRA

PROJECT_TERMS: 1 year old;8 year old;Adoption;Age;Air;Behavioral;Biomass;Birth Weight;Blood Pressure;Body mass index;Bronchodilator Agents;cardiovascular disorder risk;cardiovascular risk factor;Cessation of life;Child;Child Development;Childhood;Cholesterol;clinical outcome measures;Coal;cohort;Communities;comparison control;cooking;Cookstove;Country;critical period;Data;Dedications;Development;Dimensions;disability-adjusted life years;early childhood;Enrollment;Environmental Health;executive function;experience;Exposure to;fine particles;follow-up;Gases;Ghana;Government;Growth;Growth and Development function;Health;Health Benefit;Heating;Household;Household Air Pollution;improved;innovation;insight;Intelligence;Intervention;intervention participants;intervention program;life span;Long-Term Effects;low and middle-income countries;Lung;Measures;Methods;Monitor;multi-component intervention;multidisciplinary;Observational Study;Oscillometry;Outcome;Participant;Persons;Peru;Petroleum;Physicians;Policies;pollutant;Population;Pregnancy;premature;Psychologist;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Randomized;Randomized, Controlled Trials;Research;Research Personnel;Resistance;Resource-limited setting;response;Risk;scale up;Scientist;Serum;Smoke;social;solid fuel;Sorting;Spirometry;Temperature;Time;Triglycerides;United States National Institutes of Health;Wechsler Scales;years of life lost

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Congenital Structural Anomalies;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE Understanding how mutations in DYRK1A cause decreased neuronal growth will give us important insight into the pathobiology of ASD/ID and microcephaly and identify potential therapeutics for this condition. This proposed research will study the neurodevelopmental relationship between Dyrk1a mutations and mTOR signaling, a biological pathway known to be dysregulated in humans with autism spectrum disorder and intellectual disability. The goal of this project is to identify a mechanism by which Dyrk1a mutations cause altered brain and neuronal growth and ASD-relevant behaviors and ultimately rescue these alterations through genetic and pharmacological interventions.

PI_NAMEs: PAGE, DAMON THERON (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Adult;Area;autism spectrum disorder;Behavior;Behavioral;behavioral phenotyping;Biological;Biological Models;Brain;candidate identification;cell cortex;Cell Count;cell type;Cerebral cortex;Clinical;Cognition;Computer Analysis;Data;Data Set;design;Development;Exhibits;FRAP1 gene;Funding;Genetic;Genetic Suppression;Goals;Golgi Apparatus;Growth;Heterozygote;hippocampal pyramidal neuron;Human;Immunohistochemistry;Individual;individuals with autism spectrum disorder;insight;Insulin-Like Growth Factor I;Intellectual functioning disability;Intervention;Label;Laboratories;Lead;Link;loss of function;Macrocephaly;Measures;Medial;Methyl-CpG-Binding Protein 2;Microcephaly;Modeling;Molecular;Molecular Target;Morphology;mouse model;mTOR Signaling Pathway;mutant;Mutant Strains Mice;Mutation;neonatal mice;Neuroanatomy;neuronal cell body;neuronal growth;Neurons;Newborn Infant;NF1 gene;Pathway interactions;Peripheral;pharmacologic;Pharmacological Treatment;phosphoproteomics;Phosphorylation;Phosphotransferases;pleiotropism;Population;Prefrontal Cortex;Process;Protein Biosynthesis;Proteome;Proteomics;PTEN gene;Regulation;Reporting;Research;Risk Factors;risk variant;Signal Transduction;Specificity;Surveys;Synapses;Testing;Therapeutic;therapeutic candidate;therapeutic target;therapy development;Tissues;TSC1 gene;Tyrosine Phosphorylation;UBE3A gene;Up-Regulation;Western Blotting;Work

PROJECT_TITLE: Regulation of mTOR signaling in the developing cerebral cortex as a point of convergence for multiple autism risk factors


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The supplement will permit the purchase of a next-generation imaging device that offers superior color representation to allow our funded AI imaging grant to work with the latest scanning laser technology. The overall goal of our federally funded research study is to develop artificial intelligence-based methods of montaging images of the back of the eye from different imaging devices. This instrument is just now available, and our ophthalmology department does not have one; it will be housed in the Jacobs Retina Center and serve our overall goal of helping ophthalmologists and researchers to better understand and diagnose eye diseases.

PI_NAMEs: BARTSCH, DIRK-UWE G;FREEMAN, WILLIAM R.;NGUYEN, TRUONG Q (contact)

PROGRAM_OFFICER_NAME: GAO, JAMES

PROJECT_TERMS: Artificial Intelligence;Back;clinical diagnosis;Color;Comparative Study;Consent;Devices;Diagnosis;Eye;Eye diseases;Funding;Fundus photography;Generations;Goals;Grant;Image;Imaging Device;Institutional Review Boards;instrument;Lasers;Masks;Methods;Morphologic artifacts;multimodality;next generation;ophthalmic examination;Ophthalmologist;Ophthalmology;Ophthalmoscopes;Patients;Registries;Research;Research Personnel;research study;Retina;Retinal Diseases;retinal imaging;Scanning;Shapes;Technology;Work

PROJECT_TITLE: SCH: Multimodal Retina Image Alignment and Applications


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: Narrative This proposal aims to advance applications of long-read sequencing to the identification of genetic changes in cancer cells by developing cutting edge informatic methods for long-read sequencing analysis.

PI_NAMEs: CAMPBELL, CATARINA D.;LI, HENG  (contact);ZHANG, CHENG-ZHONG

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Algorithms;Aneuploidy;anti-cancer research;base;Benchmarking;Bioinformatics;bioinformatics tool;Biological;BRCA1 gene;BRCA2 gene;Cancer Biology;cancer cell;Cancer cell line;cancer genome;cancer genomics;Catalogs;Chromosomes;Communities;community building;Complex;Computing Methodologies;cost;Data;Data Science;Dependence;detection method;detection sensitivity;Development;Documentation;Ensure;Evaluation;Event;Foundations;frontier;Generations;Genetic Variation;Genome;genome analysis;genome sequencing;genomic platform;Germ Lines;Germ-Line Mutation;Goals;Graph;Haplotypes;Hi-C;Human Genetics;Human Genome;human genome sequencing;improved;Informatics;innovation;insertion/deletion mutation;Joints;Knowledge;Loss of Heterozygosity;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Manuals;Maps;Methods;Mutation;pan-genome;Performance;Phase;Prevalence;Process;programs;Pseudogenes;repository;Research;Research Activity;Research Personnel;Resources;Retrotransposition;Sampling;scaffold;Somatic Mutation;Tandem Repeat Sequences;telomere;tool;training data;tumor;Variant;variant detection

PROJECT_TITLE: Enhancement and further development of informatics methods for long-read cancer sequencing

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-J (M3)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE The investigation of Diffuse Midline Glioma-derived extracellular vesicles and their impact on tumor radioresistance is relevant to public health, as it addresses the leading cause of pediatric brain tumor-related deaths and seeks to provide new insights into overcoming treatment resistance. By focusing on the functional effects of extracellular vesicles and their potential as drug-delivery agents, this research is relevant to NCI’s mission of understanding cancer mechanisms and developing innovative treatment strategies.

PI_NAMEs: OZA, VIRAL  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Address;Affect;antagonist;Automobile Driving;Biodistribution;Biology;blood-brain barrier crossing;blood-brain barrier penetration;Brain;Brain Neoplasms;Cancer Biology;cancer cell;Cancer Model;cancer therapy;Cell Death Induction;cell type;Cells;Cellular biology;Central Nervous System Diseases;Cessation of life;Chemicals;Child;Childhood;Childhood Brain Neoplasm;Clinic;Clinical;combinatorial;Communication;Communities;Creativeness;Data;delivery vehicle;Development;Diagnosis;Diffuse intrinsic pontine glioma;diffuse midline glioma;Disease;DNA Repair;Drug Delivery Systems;Drug Targeting;Electroporation;Engineering;Ensure;extracellular vesicles;Fostering;Fractionated radiotherapy;Gene Expression;Genes;Genetic;Glioma;Goals;Health;Histones;Human;improved;In Vitro;Individual;inhibitor;innovation;insight;Investigation;knock-down;Knowledge;Label;Link;machine learning model;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Methods;Microfluidic Microchips;Microfluidics;MicroRNAs;Mission;Modeling;multidisciplinary;Mutation;neoplastic cell;new therapeutic target;next generation;novel;novel strategies;novel therapeutic intervention;Outcome;overexpression;Pathway interactions;Patients;Penetrance;Pharmaceutical Preparations;Phase;Population;Postdoctoral Fellow;Process;Proteomics;Public Health;Radiation;radiation resistance;Radiation therapy;Radiation Tolerance;Radiation-Sensitizing Agents;radioresistant;receptor;Research;Research Personnel;Research Project Grants;Research Training;Resistance;Role;Scientist;Signal Transduction;skills;Specificity;standard of care;success;Surface;Testing;Therapeutic;therapy resistant;tool;Training;Treatment Efficacy;Treatment outcome;treatment strategy;tumor;tumor heterogeneity;tumor microenvironment;tumor progression;Tumor-Derived;uptake;vesicular release;Xenograft Model;Xenograft procedure;Zebrafish

PROJECT_TITLE: Harnessing Extracellular Vesicles to Overcome Radiation Resistance in Pediatric Diffuse Midline Glioma


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative Glutamate-activated NMDA receptors mediate a Ca2+-permeable component of excitatory synaptic transmission in the brain that is involved in learning, memory, and development. NMDA receptors have been implicated in a wide range of neurological conditions, and there is intense interest in the development of allosteric modulators as new therapeutic treatments for neurological disease. This research program is designed to address all key aspects of glutamate receptor signaling, including the structural underpinnings of function, genetic variation as it relates to rare disease and risk factors, identification of therapeutically-relevant molecules that can be used as probes to develop novel treatment strategies, and the fundamental process of synaptic transmission.

PI_NAMEs: TRAYNELIS, STEPHEN F (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Active Biological Transport;Address;Administrative Supplement;Agonist;Alzheimer's Disease;Astrocytes;autism spectrum disorder;Binding;Binding Sites;Biology;Biophysics;Brain;Cations;Chemistry;Clinical;Collaborations;Communication;Corpus striatum structure;Cryoelectron Microscopy;Crystallography;de novo mutation;density;design;Development;Diffusion;disability;Disease;disease model;disorder risk;Electrophysiology (science);Elements;Epilepsy;Evaluation;Excision;Excitatory Synapse;experience;experimental study;falls;Functional disorder;Funding;G-Protein-Coupled Receptors;Gene Family;Gene Frequency;Genes;Genetic;genetic analysis;Genetic Variation;Genome;Glutamate Receptor;Glutamates;Hippocampus;Human;Image;improved;in vivo;in vivo Model;Individual;insight;interest;Ion Channel;Ischemia;kainate;Knock-in;Laboratories;Learning;Mediating;Memory;Molecular;Motility;Mutation;N-Methyl-D-Aspartate Receptors;nano;Nervous System Disorder;Neurologic;Neurons;Neuroprotective Agents;Neurotransmitters;NMDA receptor A1;novel;novel therapeutic intervention;novel therapeutics;Parkinson Disease;Penetration;Peptide Signal Sequences;Permeability;Pharmaceutical Chemistry;pharmacologic;PHluorin;Play;Population;post stroke;postsynaptic;precision medicine;presynaptic;Presynaptic Terminals;Probability;Process;programs;Property;Protein Region;Rare Diseases;rare variant;Reaction Time;receptor;receptor function;Receptor Signaling;Regulation;Research;Resolution;response;Risk Factors;Robotics;Role;Schizophrenia;Series;Shapes;side effect;Signal Transduction;Single Nucleotide Polymorphism;Site;Solubility;Stroke;structural biology;Structure;superresolution imaging;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;synaptogenesis;System;Thalamic structure;Therapeutic;tool;treatment strategy;treatment-resistant depression;Variant;Vertebral column;Work

PROJECT_TITLE: Glutamate receptors and human neurological disease


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Drug resistance and Acute Myeloid Leukemia burdens are associated downregulation of tumor-suppressing pro- teins and the manifestation of tumor-promoting protein fusions, but therapeutic approaches directly focused on these pivotal biomolecules remains a technical challenge. This proposal aims to investigate the roles and mech- anisms underlying RNA deregulation in primary and relapsed Acute Myeloid Leukemia. Findings from this ex- ploratory study will lead to the development of a larger grant providing the scientific basis for a novel RNA-based therapeutic for the disease that is poorly treated.

PI_NAMEs: TRINH, BON Q (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia 1 protein;acute myeloid leukemia cell;Anthracycline;Applications Grants;Ara-C;Binding;Biological Assay;cancer therapy;Cell Differentiation process;cell growth;Cell Line;Cell model;Chemoresistance;chemotherapy;Chimeric Proteins;Chromatin;Chromatin Loop;Chromatin Structure;Chromosomal translocation;Clinical;Communication;CRISPR-mediated transcriptional activation;Cytarabine;Data;Development;Disease;Disease remission;Down-Regulation;Doxorubicin;Drug resistance;Enhancers;Family;Gene Expression Regulation;Genetic Transcription;genomic data;Genomics;Goals;Grant;Hematopoietic Neoplasms;improved;Inhibition of Cell Proliferation;inhibitor;insight;leukemia treatment;Malignant Neoplasms;Mediating;Modeling;Molecular;Molecular Conformation;mouse model;Mus;Myelogenous;myeloid cell development;Myeloid Cells;novel;novel therapeutics;Oncogenic;Oncoproteins;Outcome;patient derived xenograft model;Patients;Pharmaceutical Preparations;pre-clinical;promoter;Proteins;proto-oncogene protein Spi-1;Regulation;Relapse;Repression;Research Project Grants;Resistance;response;RNA;Role;RUNX1 gene;Sampling;Structure;t(8;21) acute myeloid leukemia;t(8;21)(q22;q22);Testing;Therapeutic;therapeutic RNA;therapeutic target;Time;transcription factor;transcriptomics;tumor;Tumor Promotion;Tumor Suppressor Proteins;Untranslated RNA;Work

PROJECT_TITLE: The role of long noncoding RNAs in acute myeloid leukemia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-Y (55)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Infectious Diseases;Nanotechnology;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: Narrative The CDC reported over 176,000 cases of syphilis in the U.S. in 2021, which is a 74% increase from 2017. The current serum antibody-based diagnostic tests for Syphilis are unable to distinguish current and past infection and suffer from imperfect specificity and sensitivity. This project aims to develop a rapid (< 30 minutes) and low- cost (<$3 per test) point-of-care diagnostic assay for active Syphilis.

PI_NAMEs: CHEN, ZHILEI  (contact);WANG, CHAO

PROGRAM_OFFICER_NAME: GLOCK, JONATHAN A

PROJECT_TERMS: Acceleration;Adult;Affinity;Ankyrin Repeat;Antibiotic Therapy;Antibodies;antibody diagnostic;antigen binding;Antigen Targeting;antigen test;Antigen-Antibody Complex;Antigens;assay development;Awareness;Bacteremia;Bacteria;Binding;Binding Proteins;Biological Assay;Blood capillaries;Cells;Clinic;Clinical;Clinical Sensitivity;Cold Chains;Color;Complementary DNA;Complex;Congenital Syphilis;cost;Country;design;Detection;detection limit;detection sensitivity;Devices;Diagnosis;diagnostic assay;diagnostic technologies;Digit structure;Directed Molecular Evolution;Disease;Dissociation;DNA;Dose;effective therapy;Electronics;Engineering;engineering design;Escherichia coli;Exhibits;Future;Hour;Human;human pathogen;Immune;In Vitro;Income;Individual;Infection;Libraries;link protein;Mass Spectrum Analysis;member;men who have sex with men;microbial host;Modeling;Monitor;nanobodies;nanoGold;nanomolar;nanoparticle;nanosensors;novel;Optics;overtreatment;pathogenic bacteria;Patients;Penicillins;Pharmacy facility;Play;point of care;point-of-care diagnostics;portability;Preventive measure;Production;Property;Protein Engineering;Proteins;Public Health;Reaction;Recombinants;Reporting;repository;Sampling;Scaffolding Protein;Semiconductors;Sensitivity and Specificity;sensor;Serology test;Serum;Sexually Transmitted Diseases;Shiga-Like Toxin II;Signal Transduction;success;Syphilis;Syphilis Serodiagnosis;Tars;Technology;Testing;transmission process;Treponema pallidum;Urine;Visit;Whole Blood

PROJECT_TITLE: Novel antigen tests for diagnosing active T. pallidum infection

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cervical Cancer;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: RICE UNIVERSITY

PHR: PROJECT NARRATIVE 90% of deaths from cervical cancer occur in low and middle-income countries due to lack of access to sensitive and specific preventative screening tools. mRNA from high-risk HPV types is a sensitive and specific biomarker for assessing cervical cancer risk. This F99/K00 proposal focuses on developing and piloting technologies for detecting HPV mRNA in vitro and in vivo that are accessible to low-resource settings, helping providers monitor disease progression and informing treatment.

PI_NAMEs: NOVAK, EMILIE NEWSHAM (contact)

PROJECT_TERMS: 3-Dimensional;Address;American;American College of Obstetricians and Gynecologists;Animal Model;aptamer;Binding;Biological Assay;Biological Markers;Brazil;cancer biomarkers;Cancer Center;Cancer Detection;cancer invasiveness;cancer prevention;cancer risk;cancer therapy;career;Cell Culture Techniques;Cells;Cellular Precursor of Cancer;Cervical;Cervical Cancer Screening;Cessation of life;Clinical;clinically relevant;clinically significant;Collaborations;Communicable Diseases;Communication;cost;Coupled;Dedications;design;Detection;detection method;Development;Disease;Disease Progression;DNA;Dyes;Early Diagnosis;early screening;Early treatment;Ensure;Enzymes;Equipment;experience;fluorescence imaging;Foundations;Future;Goals;Health Personnel;high resolution imaging;high risk;HPV screening;HPV-High Risk;Human papilloma virus 45;Human Papillomavirus;Human papillomavirus 16;Human papillomavirus 18;Human Resources;Image;Imaging Techniques;improved;In Vitro;in vivo;in vivo monitoring;Incidence;Individual;Infection;Infrastructure;innovation;Institution;instrument;instrumentation;isothermal amplification;Label;Laboratories;Laboratory Personnel;Location;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mediating;Medical center;Mentors;Messenger RNA;Methods;minimally invasive;Monitor;monolayer;mortality;new technology;next generation;Noise;novel;Nucleic Acids;Oncology;Oncornaviruses;Optics;overtreatment;Patients;Performance;Phase;Pilot Projects;pilot test;point of care;Polymerase;premalignant;Preparation;Prevention strategy;Preventive screening;Preventive treatment;Primary Prevention;Process;Provider;Reaction;real time monitoring;recombinase;Recommendation;Research Personnel;Resolution;Resource-limited setting;Resources;Reverse Transcription;Rice;RNA;Sampling;screening;Screening for cancer;Screening procedure;screening program;Sensitivity and Specificity;Severity of illness;Signal Transduction;skills;specific biomarkers;standard of care;Survival Rate;Techniques;Technology;technology development;Testing;Texas;Time;Training;Translating;Triage;Universities;usability;Work;World Health Organization

PROJECT_TITLE: Human papillomavirus mRNA detection for assessing cervical cancer risk in resource-limited settings

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-U (M1)]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BALTIMORE

PHR: Pluripotent stem cells (PSCs)-derived cardiomyocytes (CMs) fail to fully mature in vitro and in adult hearts, limiting their biomedical applications. Here we propose to identify and correct the cause of the failure at the transcriptome level via a modified RNA approach. This knowledge will provide novel insights into developing a transcriptome-based strategy to produce adult-like CMs from PSCs.

PI_NAMEs: KWON, CHULAN  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Address;Adult;Affinity;Arrhythmogenic Right Ventricular Dysplasia;Biological Process;Cardiac;Cardiac Myocytes;cardiac repair;Cardiomyopathies;Cell Therapy;Cells;Chromatin;Clinical;clinical application;Clinical Trials;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;cytokine;Data Set;differential expression;Disease;disease model;DNA;Dose;droplet sequencing;Embryo;Engineering;Engraftment;Entropy;Failure;Gene Abnormality;gene conservation;Gene Expression;gene network;gene regulatory network;Genes;Genetic Transcription;Growth Factor;Heart;human data;human pluripotent stem cell;improved;In Vitro;in vivo;Individual;insight;Knowledge;knowledge of results;Late-Onset Disorder;Light;loss of function;Maps;Medicine;Metabolic;Methods;Modeling;Modification;mosaic;Mus;novel;Outcome;overexpression;Perinatal;Phenotype;Physiological;Pluripotent Stem Cells;pre-clinical;premature;Process;programs;reconstruction;repair model;Research Personnel;Resolution;response;restoration;RNA;Role;Sampling;single-cell RNA sequencing;Somatotype;Stimulus;Structure;Testing;Time;Tissue Engineering;Transcript;transcription factor;transcriptome;transcriptomics;Up-Regulation

PROJECT_TITLE: Targeting Dysregulated Maturation Program in PSC-Cardiomyocytes

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Brain Disorders;Neurosciences

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative: Cerebellar ataxias are debilitating neurological disorders. The next generation of therapies for neurological disorders will need to understand how cerebellum actuates control to manipulate specific output pathways. The proposed studies will provide insight into how cerebellar circuits are causally involved in refining movements and test specific neural pathways in fine tuning control, potentially offering therapeutic targets for intervention in patients with cerebellar dysfunction or movement disorders.

PI_NAMEs: PERSON, ABIGAIL L (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Acute;Address;Afferent Neurons;Behavior;behavior influence;Behavioral;Behavioral Paradigm;Calibration;Cell Nucleus;cell type;Cells;Cerebellar Ataxia;Cerebellar Diseases;Cerebellum;Complex;Computer Models;Deceleration;Detection;Dissociation;Dysmetria;Educational process of instructing;Electrophysiology (science);Event;examination questions;experimental study;Frequencies;Future;Goals;grasp;Image;Impairment;Inferior;inhibitory neuron;insight;Intervention;kinematics;Learning;Learning Skill;Limb structure;Mammals;Measures;Mediating;Methods;Modeling;Monitor;Motor;motor control;Motor Neurons;Movement;Movement Disorders;Mus;Nervous System Disorder;Neural Pathways;neuronal patterning;Neurons;next generation;Olives - dietary;Outcome;Outcome Study;Output;Pathway interactions;Patients;Performance;Phenotype;Positioning Attribute;Purkinje Cells;Role;Sensory;Signal Transduction;skill acquisition;skills;Structure;teacher;Testing;theories;therapeutic target;Weight;Work

PROJECT_TITLE: Functional roles of inhibitory cerebellar outputs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-T (02)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: WORCESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: NARRATIVE Our project focuses on developing a comprehensive platform to analyze and visualize cancer-specific regulatory genomics and chromatin structure, utilizing extensive genomic data from sources like TCGA, TARGET, and ICGC. This initiative includes creating a regulatory-element–target-gene atlas, identifying and predicting the effects of genetic aberrations on regulatory elements, and building an integrated, user-friendly web platform for data visualization and outreach within the scientific community.

PI_NAMEs: WENG, ZHIPING  (contact)

PROGRAM_OFFICER_NAME: MECHANIC, LEAH E

PROJECT_TERMS: 3-Dimensional;Abnormal Cell;Address;Adoption;Affect;anti-cancer research;Architecture;Atlases;Binding Sites;Cancer Biology;cancer care;cancer genomics;Cancer Research Project;cancer subtypes;cancer type;care outcomes;cell growth;cell type;Chromatin;Chromatin Structure;Chromosomal Rearrangement;Clinical;Clinical Data;clinically relevant;cloud based;Collaborations;Communication;Communities;Community Outreach;Complex;Comprehension;Data;Data Analyses;data integration;data platform;Data Set;Data Sources;data visualization;Dedications;deep sequencing;Development;Disease;diverse data;DNA;DNA Sequence Alteration;Educational workshop;Elements;Enhancers;Ensure;Environment;Epigenetic Process;experimental study;flexibility;Funding;Gene Abnormality;Gene Expression;Gene Expression Regulation;gene network;Generations;Genes;Genetic;Genome;genomic data;Genomics;Germ Lines;Germ-Line Mutation;Goals;High-Throughput Nucleotide Sequencing;Human;Human Genome;improved;Individual;Informatics;insight;interest;Malignant Neoplasms;Maps;Medicine;meetings;member;Methods;Molecular;molecular phenotype;molecular subtypes;Mutation;next generation sequencing;Normal Cell;Normal tissue morphology;novel;Oncogenes;Oncogenic;Online Systems;open source;Other Genetics;Outcome;outreach;Pathway interactions;Patient-Focused Outcomes;Persons;Play;precision medicine;Prognosis;promoter;Registries;Regulation;Regulator Genes;Regulatory Element;Research Personnel;Resources;RNA;Role;social media;Somatic Mutation;Source;Susceptibility Gene;Technology;The Cancer Genome Atlas;tool;transcription factor;treatment response;tumor;Tumor Suppressor Genes;tumorigenesis;tumorigenic;Untranslated RNA;Up-Regulation;user-friendly;Variant;virtual;Visual;Visualization;Visualization software;web platform;web portal

PROJECT_TITLE: Integrative Analysis and Visualization Platform for Cancer Regulatory Genomics

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-9 (M1)]


ADMINISTERING_IC: GM

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: Project Narrative: Most microbes that affect our health self-organize into spatially structured communities, for example on surfaces where they form biofilms or in crypts or the lumen of the gut where they form interacting collectives. By elucidating and thoroughly testing how the self-organization of a key pathogen interplays with antimicrobial resistance evolution in vitro and in vivo, this project can offer valuable insights for spatial structure-based methods to mitigate or slow drug resistance evolution. More generally, an improved understanding of the basic forces of evolution in spatially structured populations provides foundational knowledge for modeling a wide range of evolutionary processes and formulating hypotheses about drug resistance in other evolutionary diseases.

PI_NAMEs: HALLATSCHEK, OSKAR  (contact);PARTHASARATHY, RAGHUVEER

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: adaptive optics;Affect;Antibiotics;antimicrobial;Antimicrobial Resistance;Appearance;Biological Assay;Biological Models;Biophysics;Cells;Collaborations;Communities;Complex;Computer Simulation;Crowding;de novo mutation;Diffusion;Disease;Drug resistance;drug resistance development;emerging antimicrobial resistance;Engineering;Environment;Evolution;Exhibits;experimental study;fitness;fluorescence imaging;Fluorescence Microscopy;Genetic Drift;genetic predictors;genetic selection;global health;Goals;Grain;Growth;gut microbiome;Health;Human;Image;Imaging Techniques;improved;In Vitro;in vivo;Individual;insight;Invaded;Joints;Knowledge;Laboratories;Light;Link;Maps;mathematical model;Measures;Methods;Microbe;microbial;Microbial Biofilms;Microfluidics;Microscopic;Microscopy;model organism;Modeling;Monitor;multi-photon;multi-scale modeling;Mutagenesis;Mutation;Natural Selections;Nature;Optics;organizational structure;Outcome;pathogen;Physics;Population;Population Dynamics;Population Genetics;Population Sizes;Process;Property;Reaction;Reproducibility;Research;Resistance;Resistance development;resistance gene;resistance mechanism;resistance mutation;Resolution;self organization;simulation;spatiotemporal;Stable Populations;Structure;Surface;Suspensions;synergism;synthetic biology;System;Techniques;Technology;Testing;theories;Time;Training;Tube;Variant;Vibrio cholerae;Zebrafish

PROJECT_TITLE: Unraveling the Interplay Between Self-Organization and Antimicrobial Resistance Evolution Across Spatial Scales

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Women's Health Research

ORG_CITY: RICHMOND

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: PROJECT NARRATIVE Psychological distress is a common symptom experienced by breast cancer survivors, however data about psychological distress in Black breast cancer survivors is sparse. This study will address these gaps by leveraging an existing longitudinal cohort data and primary qualitative interview and focus group data, to a) explore healthcare delivery and psychosocial factors that contribute to psychological distress among Black breast cancer survivors, and b) the strategies employed by Black breast cancer survivors to cope with psychological distress. Findings from this study may offer opportunities to develop multilevel interventions seeking to improve psychological distress outcomes in Black breast cancer survivors.

PI_NAMEs: TARIQ, FARIHA  (contact)

PROJECT_TERMS: Address;Affect;African American;Anxiety;Area;Black race;black women;Breast Cancer survivor;cancer care;cancer health disparity;Cancer Model;Cancer Survivor;Cancer Survivorship;Characteristics;Clinical;Collection;common symptom;Communication;community engaged approach;coping;Coping Skills;Data;Development;Distress;Ensure;experience;Focus Groups;Goals;Health;health care delivery;Healthcare;improved;Intervention;Interview;Left;Literature;Longitudinal cohort;Longitudinal cohort study;Malignant Breast Neoplasm;Mediating;Medical;Mental Depression;Mentors;Methodology;Methods;Modeling;multidisciplinary;Nature;Outcome;patient-clinician communication;Patients;perceived discrimination;Phase;Postdoctoral Fellow;pre-doctoral;prevent;Provider;psychologic;psychological distress;Psychological Impact;Psychosocial Factor;Qualifying;Quality of life;Race;racial difference;racial disparity;Reporting;Research;Research Project Grants;Research Proposals;Role;sociodemographic factors;sociodemographics;Solid;Survivors;survivorship;Testing;theories;Training;treatment adherence;United States National Institutes of Health;Work

PROJECT_TITLE: An In-depth Examination of Psychological Distress among Black Breast Cancer Survivors


NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Genetics;Immunotherapy;Orphan Drug;Precision Medicine;Rare Diseases;Skin Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE PIK3CA mutant positive tumor-initiating cells (TICs) can resist anti-tumor immunity and drive tumor relapse after immune checkpoint blockade (ICB) treatment in squamous cell carcinomas (SCCs). The F99 phase of this proposal will determine how PIK3CA mutations expand the immune-resistant TICs in SCC tumors by stabilizing the Sox2 transcription factor following ICB. The K00 phase will dissect how PIK3CA mutations enhance TIC immune resistance to T cell-mediated ferroptosis and how other genetic determinants confer stemness and intrinsic immune resistance to TICs, revealing novel drug targets and biomarkers for predicting patient responses to immunotherapy.

PI_NAMEs: NICHOLSON, BENJAMIN  (contact)

PROJECT_TERMS: Acceleration;Affect;Antigen Presentation;Automobile Driving;biomarker signature;Cancer Biology;cancer recurrence;Cancer Relapse;cancer stem cell;cancer therapy;Candidate Disease Gene;candidate identification;Catalytic Domain;Cell-Mediated Cytolysis;Cells;Cervix Uteri;Chromosomal Rearrangement;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;combat;Copy Number Polymorphism;CRISPR screen;Cutaneous;design;Development;Disparity;Drug Targeting;Endowment;Esophagus;Exhibits;experience;experimental study;fatty acid metabolism;Funding;Future;Gene Fusion;Genes;Genetic;Genetic Determinism;Genetic Variation;Genetically Engineered Mouse;genome-wide;Goals;Granzyme;grasp;Head and Neck Squamous Cell Carcinoma;Head and neck structure;Immune;immune checkpoint blockade;Immune Evasion;immune resistance;Immunology;Immunotherapy;improved;in utero;in vivo;Individual;Induced Mutation;insight;Institution;keratinocyte;Laboratory Research;Larynx;Lung;Malignant Epithelial Cell;Malignant Neoplasms;Maps;Mediating;Microinjections;Molecular;mouth squamous cell carcinoma;multiple omics;mutant;Mutation;neoplastic cell;new therapeutic target;next generation;novel;Oncogene Activation;Oncogenic;Oral cavity;Other Genetics;patient response;patient subsets;Patient-Focused Outcomes;Patients;personalized immunotherapy;Phase;Phosphatidylinositols;Phosphotransferases;PIK3CA gene;Play;Population;Postdoctoral Fellow;predictive marker;predictive signature;programs;Proteins;rare cancer;Recurrence;Relapse;Research;Research Personnel;Research Project Grants;Resistance;resistance mechanism;response;Role;self-renewal;Skin;skin squamous cell carcinoma;Squamous cell carcinoma;stem cell biology;stem cells;stemness;T-Lymphocyte;Techniques;Testing;Tissues;transcription factor;tumor;Tumor Escape;Tumor Expansion;Tumor Immunity;tumor immunology;tumor initiation;tumor metabolism;Tumor Suppressor Proteins;United States National Institutes of Health;Work

PROJECT_TITLE: Dissecting the genetic basis of cancer immune evasion in squamous cell carcinoma


NIH_SPENDING_CATS: Autoimmune Disease;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Rare Diseases;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE Kawasaki Disease (KD) is the leading cause of acquired heart disease among children. In this proposal we will identify novel mechanisms underlying IL-1-mediated regulation of pathologies leading to vasculitis, aortic aneurysm formation in male versus female with KD, which will lead to new avenues for both prevention and treatment of cardiovascular complications in KD and possibly in other immune vascular diseases.

PI_NAMEs: ARDITI, MOSHE  (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Acute;Adult;Affect;Angiotensin II Receptor;Aortic Aneurysm;Attenuated;Automobile Driving;Awareness;Blood Vessels;Cardiac;Cardiovascular Diseases;Cardiovascular system;Cell Communication;Cell Physiology;Cell Wall;Cessation of life;Child;Childhood;Clinical;Contractile Proteins;Coronary;Coronary Aneurysm;Coronary artery;Data;Dendritic Cells;Development;Disease;Disease Progression;Etiology;Exhibits;experience;Female;Fever;Fibroblasts;Functional disorder;Gene Expression;Health;Heart Diseases;high risk;Human;human disease;Illness Days;Immune;Immunoglobulin G;improved;Infiltration;Inflammation;Inflammatory;Interleukin-1;Interleukin-1 beta;Interleukin-1 Receptors;Interleukins;Intravenous;Lactobacillus casei;Lesion;Macrophage;male;Matrix Metalloproteinases;Mediating;Medical;Modeling;monocyte;mouse model;Mucocutaneous Lymph Node Syndrome;Mus;Myocardial Infarction;Myocardial Ischemia;Myofibroblast;neutrophil;novel;novel therapeutic intervention;Outcome;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Phenotype;prevent;Prevention;Production;Proliferating;Property;Publishing;recruit;Regulation;Resistance;Role;Severities;sex;Sex Differences;sex disparity;sexual dimorphism;Signal Transduction;Smooth Muscle Myocytes;Source;stem;Stromal Cells;targeted treatment;Testing;Therapeutic;Tissues;Transcript;transcriptomics;Vascular Diseases;Vascular Smooth Muscle;Vasculitis;women patients;women versus men

PROJECT_TITLE: Role of Sex in Immune Stromal cell Interactions driving cardiovascular lesions in Kawasaki Disease vasculitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-F (50)]


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Sophisticated single-cell and spatial multi-omics data provide unprecedented characterization of the regulatory programs of cellular phenotypes in tumors and their microenvironments, but they do not capture the dynamics of cell interactions that drive cancer progression. Agent-based simulation models (ABMs) allow scientists to test hypotheses as model rules, but it is challenging to determine model rules from imaging data. This project will merge state-of-the-art bioinformatics tools for spatial multi-omics data with web-hosted ABM software to give scientists new, biologically interpretable tools to learn, refine, and manipulate the rules of cancer ecosystems, paving the way for future cancer patient digital twins and next-generation predictive medicine. ‘

PI_NAMEs: FERTIG, ELANA ;MACKLIN, PAUL T (contact)

PROJECT_TERMS: Atlas of Cancer Mortality in the United States;Automation;Behavioral;Bioconductor;Bioinformatics;bioinformatics pipeline;bioinformatics tool;Calibration;Cancer Model;Cancer Patient;cell behavior;Cell Communication;cell killing;Cell model;cell transformation;cell type;Cells;Cellular biology;Cessation of life;cloud based;Cloud Computing;Code;Communities;Complex;computer code;computer infrastructure;Computer software;cost;Data;data integration;Data Set;data-driven model;Development;Dictionary;digital;digital twin;Documentation;Ecosystem;Education;Educational Materials;Educational workshop;empowerment;Environment;Experimental Designs;Feedback;flexibility;Future;genomic data;Glues;hackathon;High Performance Computing;Human;Image;Individual;individual patient;Infrastructure;Internet;Intuition;Investigation;Knowledge;Label;Language;Learning;learning network;Libraries;Ligands;Malignant Neoplasms;Manuals;Mathematical Biology;mathematical model;Measurement;Medicine;Methods;migration;Modeling;models and simulation;Molecular;Molecular Analysis;Motion;Movement;multidisciplinary;Multiomic Data;multiple omics;neoplastic cell;next generation;novel;open source;Patients;Performance;Phagocytosis;Phenotype;Positioning Attribute;Process;programs;prototype;Publishing;Pythons;real time model;receptor;Reproducibility;Research;Resources;Running;Science;Scientist;Secure;Signal Transduction;simulation;single cell analysis;software development;Structure;System;T-Lymphocyte;Technology;Testing;Tissues;tool;Training;transcriptomics;treatment response;tumor;tumor microenvironment;tumor progression;Uncertainty;usability;user friendly software;Validation;virtual;virtual clinical trial;virtual experiments;Visualization;Writing

PROJECT_TITLE: Informing mechanistic rules of agent-based models with single-cell multi-omics